Chr	Start	End	Ref	Alt	MitImpact_id	Gene_symbol	OXPHOS_complex	Ensembl_gene_id	Ensembl_protein_id	Ensembl_transcript_id	Uniprot_name	Uniprot_id	Ncbi_gene_id	Ncbi_protein_id	Gene_position	AA_position	AA_ref	AA_alt	Codon_substitution	PhyloP_100V	PhastCons_100V	SiteVar	PolyPhen2	PolyPhen2_score	SIFT	SIFT_score	FatHmmW	FatHmmW_score	FatHmm	FatHmm_score	PROVEAN	PROVEAN_score	MutationAssessor	MutationAssessor_score	EFIN_SP_score	EFIN_SP	EFIN_HD_score	EFIN_HD	CADD_score	CADD_phred_score	CADD	VEST_pvalue	VEST_FDR	PANTHER_score	PANTHER	PhD-SNP_score	PhD-SNP	SNAP_score	SNAP	Meta-SNP_score	Meta-SNP	Meta-SNP_RI	CAROL_score	CAROL	Condel_score	Condel	COVEC_WMV_score	COVEC_WMV	MtoolBox_DS	MtoolBox	PolyPhen2_transf_score	PolyPhen2_transf	SIFT_transf_score	SIFT_transf	MutationAssessor_transf_score	MutationAssessor_transf	CHASM_pvalue	CHASM_FDR	MISTIC_coevo_sites	MISTIC_mean_MI_score	APOGEE_boost_mean_prob	APOGEE_boost_consensus	SNPDryad_score	MutationTaster	MutationTaster_score	DEOGEN_Score	dbSNP_151_id	ClinVar_June2018_ClinSig	ClinVar_June2018_ClnDBN	ClinVar_June2018_ClnALLELEID	ClinVar_June2018_ClnDSDB	MITOMAP_Dec2016_Somatic_occurrence	COSMIC_87	CPD_candidate	CPD_frequency	Mitomap_Allele	Mitomap_Phenotype	Mitomap_Homoplasmy	Mitomap_Heteroplasmy	Mitomap_Status	Mitomap_NRef	Classification_Clinvar	Classification_Mitomap	Classification_global	Mitoclass1
chrM	8527	8527	A	C	MI.1	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	1	1	M	L	Atg/Ctg	2.21	1	0	possibly_damaging	0.52	deleterious	0.02	neutral	4.7	neutral	0.88	neutral	-2.48	NA	NA	0.63	neutral	0.08	damaging	3.93	23.50	deleterious	0.38	0.65	0.68	disease	0.34	neutral	0.63	disease	0.57	disease	1	0.98	neutral	0.25	neutral	3	deleterious	0.51	deleterious	NA	NA	NA	NA	NA	NA	0.50	0.9	50	8.74	0.5	P	0.93	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8527	8527	A	G	MI.24190	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	1	1	M	V	Atg/Gtg	NA	NA	NA	possibly damaging	0.619	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.43	neutral		neutral	0.41	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.53	deleterious	NA	NA	NA	NA	NA	NA	NA	NA	50	8.74	NA	NA	NA	NA	NA	NA	rs878853003	Likely_benign	not_provided	236981	MedGen:CN517202	.	.	.	.	A8527G	Neuromuscular disorder, possible helper mutation	+	-	Reported	1	N	.	N	neutral
chrM	8531	8531	A	T	MI.10	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	5	2	N	I	aAc/aTc	6.84	1	0	probably_damaging	0.99	neutral	0.57	neutral	4.65	neutral	-0.66	deleterious	-4.59	low_impact	1.4	0.86	neutral	0.52	neutral	3.71	23.30	deleterious	0.47	0.65	0.32	neutral	0.53	disease	0.27	neutral	0.51	disease	0	0.99	deleterious	0.29	neutral	-2	neutral	0.66	deleterious	-2.65	low_impact	0.36	medium_impact	0.1	medium_impact	0.42	0.9	41.59	7.23	0.5	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8572	8572	G	A	MI.100	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	46	16	G	S	Ggc/Agc	0.13	0.8	0.01	possibly_damaging	0.56	neutral	0.17	neutral	4.67	neutral	0.05	deleterious	-4.62	medium_impact	2.23	0.96	neutral	0.43	neutral	3.50	23.10	deleterious	0.38	0.65	0.52	disease	0.8	disease	0.44	neutral	0.54	disease	1	0.82	neutral	0.31	neutral	0	NA	0.61	deleterious	-0.86	medium_impact	-0.1	medium_impact	0.81	medium_impact	0.84	0.9	17.26	11.64	0.35	N	0.66	disease_causing	1	0.09	rs28502681	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8995	8995	G	A	MI.1000	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	469	157	A	T	Gcc/Acc	-1.26	0	0	probably_damaging	1	neutral	0.3	neutral	3.7	neutral	-1.55	deleterious	-2.93	low_impact	1.34	0.77	neutral	0.51	neutral	4.34	24.00	deleterious	0.43	0.65	0.43	neutral	0.73	disease	0.58	disease	0.66	disease	3	1	deleterious	0.15	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.08	medium_impact	0.05	medium_impact	0.78	0.9	48.67	9	0.26	N	0.80	polymorphism	0.94	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15530	15530	T	G	MI.10000	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	784	262	L	V	Tta/Gta	-11.75	0	0.01	probably_damaging	0.92	neutral	0.56	neutral	2.73	neutral	-1.71	neutral	-2.17	high_impact	4.51	0.87	neutral	0.11	damaging	1.70	14.39	neutral	0.18	0.45	0.45	neutral	0.47	neutral	0.65	disease	0.49	neutral	0	0.91	neutral	0.32	neutral	2	deleterious	0.67	deleterious	-1.72	low_impact	0.28	medium_impact	2.9	high_impact	0.45	0.8	58.16	8.43	0.36	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15531	15531	T	G	MI.10001	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	785	262	L	W	tTa/tGa	-0.52	0	0	probably_damaging	1	neutral	0.2	neutral	2.6	deleterious	-5.26	deleterious	-4.42	high_impact	5.07	0.88	neutral	0.08	damaging	3.82	23.40	deleterious	0.04	0.35	0.85	disease	0.53	disease	0.7	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.1	medium_impact	3.41	high_impact	0.17	0.8	58.16	8.43	0.63	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15531	15531	T	C	MI.10002	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	785	262	L	S	tTa/tCa	-0.52	0	0	probably_damaging	1	neutral	0.42	neutral	2.66	neutral	-2.86	deleterious	-4.39	high_impact	4.26	0.85	neutral	0.08	damaging	3.61	23.20	deleterious	0.04	0.35	0.65	disease	0.69	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.15	medium_impact	2.67	high_impact	0.19	0.8	58.16	8.43	0.32	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15532	15532	A	T	MI.10003	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	786	262	L	F	ttA/ttT	5.67	0.87	0	probably_damaging	0.99	neutral	0.72	neutral	2.67	neutral	-2.48	deleterious	-2.93	medium_impact	2.83	0.88	neutral	0.09	damaging	3.30	22.90	deleterious	0.09	0.35	0.33	neutral	0.57	disease	0.58	disease	0.63	disease	3	0.99	deleterious	0.37	neutral	1	deleterious	0.74	deleterious	-2.59	low_impact	0.44	medium_impact	1.38	medium_impact	0.40	0.8	58.16	8.43	0.36	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15532	15532	A	C	MI.10004	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	786	262	L	F	ttA/ttC	5.67	0.87	0	probably_damaging	0.99	neutral	0.72	neutral	2.67	neutral	-2.48	deleterious	-2.93	medium_impact	2.83	0.88	neutral	0.09	damaging	3.14	22.60	deleterious	0.09	0.35	0.33	neutral	0.57	disease	0.58	disease	0.63	disease	3	0.99	deleterious	0.37	neutral	1	deleterious	0.74	deleterious	-2.59	low_impact	0.44	medium_impact	1.38	medium_impact	0.40	0.8	58.16	8.43	0.36	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15533	15533	A	C	MI.10005	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	787	263	N	H	Aac/Cac	-2.12	0	0	possibly_damaging	0.64	neutral	0.54	neutral	3.13	neutral	-1.54	neutral	-0.9	medium_impact	2.29	0.94	neutral	0.33	neutral	1.79	14.90	neutral	0.23	0.45	0.6	disease	0.36	neutral	0.59	disease	0.65	disease	3	0.6	neutral	0.45	neutral	0	NA	0.44	deleterious	-0.96	medium_impact	0.26	medium_impact	0.89	medium_impact	0.17	0.8	51.58	8.47	0.29	N	0.77	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15533	15533	A	T	MI.10006	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	787	263	N	Y	Aac/Tac	-2.12	0	0	possibly_damaging	0.74	neutral	1	neutral	3.15	neutral	-2.29	neutral	-0.45	medium_impact	2.74	0.94	neutral	0.41	neutral	2.34	18.44	deleterious	0.12	0.4	0.67	disease	0.5	neutral	0.58	disease	0.68	disease	4	0.74	neutral	0.63	deleterious	0	NA	0.58	deleterious	-1.16	low_impact	1.85	high_impact	1.29	medium_impact	0.16	0.8	51.58	8.47	0.22	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15533	15533	A	G	MI.10007	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	787	263	N	D	Aac/Gac	-2.12	0	0	benign	0.06	neutral	0.2	neutral	3.15	neutral	-0.23	neutral	-0.83	medium_impact	2.54	0.91	neutral	0.37	neutral	1.04	10.89	neutral	0.3	0.45	0.46	neutral	0.36	neutral	0.55	disease	0.5	neutral	0	0.78	neutral	0.57	deleterious	-3	neutral	0.18	neutral	0.38	medium_impact	-0.1	medium_impact	1.11	medium_impact	0.22	0.8	51.58	8.47	0.43	N	0.91	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15534	15534	A	G	MI.10008	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	788	263	N	S	aAc/aGc	2	0.01	0	benign	0	neutral	0.4	neutral	3.2	neutral	0.33	neutral	0.13	neutral_impact	-0.07	0.98	neutral	0.93	neutral	-0.40	0.39	neutral	0.36	0.5	0.27	neutral	0.23	neutral	0.3	neutral	0.42	neutral	2	0.6	neutral	0.7	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.13	medium_impact	-1.26	low_impact	0.20	0.8	51.58	8.47	0.41	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15534	15534	A	C	MI.10009	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	788	263	N	T	aAc/aCc	2	0.01	0	benign	0.06	neutral	0.4	neutral	3.19	neutral	-0.52	neutral	0.6	low_impact	1.38	0.97	neutral	0.49	neutral	0.46	7.14	deleterious	0.18	0.45	0.42	neutral	0.41	neutral	0.26	neutral	0.48	neutral	0	0.56	neutral	0.67	deleterious	-6	neutral	0.17	neutral	0.38	medium_impact	0.13	medium_impact	0.06	medium_impact	0.28	0.8	51.58	8.47	0.38	N	0.72	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8996	8996	C	A	MI.1001	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	470	157	A	D	gCc/gAc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	3.61	deleterious	-3.98	deleterious	-3.81	medium_impact	3.02	0.76	neutral	0.43	neutral	4.57	24.40	deleterious	0.1	0.65	0.72	disease	0.94	disease	0.69	disease	0.83	disease	7	1	deleterious	0	neutral	5	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	1.49	medium_impact	0.69	0.9	48.67	9	0.46	N	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15534	15534	A	T	MI.10010	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	788	263	N	I	aAc/aTc	2	0.01	0	possibly_damaging	0.6	neutral	0.4	neutral	3.23	neutral	-1.81	neutral	1.46	neutral_impact	0.08	0.92	neutral	0.59	neutral	2.54	19.71	deleterious	0.13	0.4	0.54	disease	0.41	neutral	0.27	neutral	0.53	disease	1	0.64	neutral	0.4	neutral	-3	neutral	0.39	neutral	-0.9	medium_impact	0.13	medium_impact	-1.12	low_impact	0.16	0.8	51.58	8.47	0.39	N	0.98	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15535	15535	C	A	MI.10011	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	789	263	N	K	aaC/aaA	-0.98	0	0.08	benign	0.15	neutral	0.29	neutral	3.21	neutral	1.19	neutral	-0.51	neutral_impact	0.39	0.93	neutral	0.35	neutral	2.98	22.20	deleterious	0.22	0.45	0.27	neutral	0.43	neutral	0.57	disease	0.49	neutral	0	0.66	neutral	0.57	deleterious	-6	neutral	0.23	neutral	-0.03	medium_impact	0.01	medium_impact	-0.84	medium_impact	0.34	0.8	51.58	8.47	0.33	N	0.93	polymorphism	1	0.01	rs28357371	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15535	15535	C	G	MI.10012	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	789	263	N	K	aaC/aaG	-0.98	0	0.08	benign	0.15	neutral	0.29	neutral	3.21	neutral	1.19	neutral	-0.51	neutral_impact	0.39	0.93	neutral	0.35	neutral	2.56	19.83	deleterious	0.22	0.45	0.27	neutral	0.43	neutral	0.57	disease	0.49	neutral	0	0.66	neutral	0.57	deleterious	-6	neutral	0.23	neutral	-0.03	medium_impact	0.01	medium_impact	-0.84	medium_impact	0.34	0.8	51.58	8.47	0.33	N	0.93	polymorphism	1	0.01	rs28357371	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15536	15536	A	G	MI.10013	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	790	264	T	A	Acc/Gcc	-7.17	0	0	benign	0	neutral	0.55	neutral	1.81	deleterious	-5.45	deleterious	-3.77	high_impact	4.07	0.98	neutral	0.16	damaging	1.56	13.63	neutral	0.13	0.4	0.65	disease	0.41	neutral	0.8	disease	0.66	disease	3	0.45	neutral	0.78	deleterious	-2	neutral	0.25	neutral	2.07	high_impact	0.27	medium_impact	2.5	high_impact	0.28	0.8	57.89	8.75	0.36	N	0.59	polymorphism	1	0.13	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15536	15536	A	C	MI.10014	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	790	264	T	P	Acc/Ccc	-7.17	0	0	benign	0.34	neutral	0.37	neutral	1.77	deleterious	-6.84	deleterious	-4.56	high_impact	5.3	0.95	neutral	0.06	damaging	1.86	15.35	deleterious	0.04	0.35	0.88	disease	0.61	disease	0.73	disease	0.74	disease	5	0.56	neutral	0.52	deleterious	-2	neutral	0.63	deleterious	-0.46	medium_impact	0.1	medium_impact	3.62	high_impact	0.35	0.8	57.89	8.75	0.55	P	0.95	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15536	15536	A	T	MI.10015	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	790	264	T	S	Acc/Tcc	-7.17	0	0	benign	0.03	neutral	0.38	neutral	1.97	deleterious	-3.36	deleterious	-3.02	high_impact	3.88	0.93	neutral	0.09	damaging	1.39	12.73	neutral	0.26	0.45	0.57	disease	0.49	neutral	0.73	disease	0.67	disease	3	0.59	neutral	0.68	deleterious	-2	neutral	0.28	neutral	0.68	medium_impact	0.11	medium_impact	2.33	high_impact	0.52	0.8	57.89	8.75	0.35	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15537	15537	C	T	MI.10016	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	791	264	T	I	aCc/aTc	4.52	0.99	0	benign	0.3	neutral	0.45	neutral	1.77	deleterious	-7.22	deleterious	-4.55	high_impact	5.3	0.93	neutral	0.11	damaging	3.70	23.30	deleterious	0.06	0.35	0.91	disease	0.63	disease	0.79	disease	0.73	disease	5	0.46	neutral	0.58	deleterious	-2	neutral	0.58	deleterious	-0.39	medium_impact	0.18	medium_impact	3.62	high_impact	0.52	0.8	57.89	8.75	0.65	P	0.83	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15537	15537	C	A	MI.10017	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	791	264	T	N	aCc/aAc	4.52	0.99	0	benign	0.34	neutral	0.36	neutral	1.79	deleterious	-5.9	deleterious	-3.79	high_impact	4.96	0.93	neutral	0.09	damaging	2.07	16.67	deleterious	0.21	0.45	0.87	disease	0.68	disease	0.81	disease	0.75	disease	5	0.57	neutral	0.51	deleterious	-2	neutral	0.53	deleterious	-0.46	medium_impact	0.09	medium_impact	3.31	high_impact	0.39	0.8	57.89	8.75	0.66	P	0.84	polymorphism	1	0.27	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15537	15537	C	G	MI.10018	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	791	264	T	S	aCc/aGc	4.52	0.99	0	benign	0.03	neutral	0.38	neutral	1.97	deleterious	-3.36	deleterious	-3.02	high_impact	3.88	0.93	neutral	0.09	damaging	1.78	14.87	neutral	0.26	0.45	0.57	disease	0.49	neutral	0.73	disease	0.67	disease	3	0.59	neutral	0.68	deleterious	-2	neutral	0.28	neutral	0.68	medium_impact	0.11	medium_impact	2.33	high_impact	0.52	0.8	57.89	8.75	0.54	P	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15539	15539	C	A	MI.10019	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	793	265	P	T	Cct/Act	-13.35	0	0	probably_damaging	1	neutral	0.45	neutral	1.14	deleterious	-7.47	deleterious	-5.97	high_impact	4.42	0.92	neutral	0.45	neutral	3.65	23.20	deleterious	0.05	0.35	0.67	disease	0.84	disease	0.71	disease	0.73	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.18	medium_impact	2.82	high_impact	0.42	0.8	59.74	8.69	0.43	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8996	8996	C	T	MI.1002	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	470	157	A	V	gCc/gTc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	3.65	neutral	-2.41	deleterious	-3.3	medium_impact	2.67	0.82	neutral	0.56	neutral	4.63	24.50	deleterious	0.4	0.65	0.73	disease	0.84	disease	0.59	disease	0.74	disease	5	1	deleterious	0	neutral	5	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	1.19	medium_impact	0.76	0.9	48.67	9	0.51	P	0.75	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15539	15539	C	G	MI.10020	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	793	265	P	A	Cct/Gct	-13.35	0	0	probably_damaging	0.99	neutral	0.5	neutral	1.15	deleterious	-6.7	deleterious	-5.98	high_impact	5.31	0.94	neutral	0.49	neutral	1.57	13.68	neutral	0.06	0.35	0.62	disease	0.63	disease	0.75	disease	0.72	disease	4	0.99	deleterious	0.26	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.22	medium_impact	3.63	high_impact	0.56	0.8	59.74	8.69	0.62	P	0.84	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15539	15539	C	T	MI.10021	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	793	265	P	S	Cct/Tct	-13.35	0	0	probably_damaging	1	neutral	0.39	neutral	1.16	deleterious	-6.46	deleterious	-5.98	high_impact	4.76	0.93	neutral	0.45	neutral	3.83	23.40	deleterious	0.05	0.35	0.63	disease	0.79	disease	0.66	disease	0.68	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.12	medium_impact	3.13	high_impact	0.23	0.8	59.74	8.69	0.6	P	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15540	15540	C	T	MI.10022	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	794	265	P	L	cCt/cTt	4.29	0.99	0	probably_damaging	1	neutral	0.64	neutral	1.14	deleterious	-7.35	deleterious	-7.5	high_impact	4.28	0.93	neutral	0.37	neutral	4.38	24.10	deleterious	0.05	0.35	0.66	disease	0.85	disease	0.71	disease	0.74	disease	5	1	deleterious	0.32	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.36	medium_impact	2.69	high_impact	0.62	0.8	59.74	8.69	0.49	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15540	15540	C	G	MI.10023	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	794	265	P	R	cCt/cGt	4.29	0.99	0	probably_damaging	1	neutral	0.33	neutral	1.13	deleterious	-8.18	deleterious	-6.73	high_impact	4.62	0.93	neutral	0.35	neutral	3.66	23.20	deleterious	0.03	0.35	0.69	disease	0.86	disease	0.78	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.06	medium_impact	3	high_impact	0.31	0.8	59.74	8.69	0.58	P	0.80	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15540	15540	C	A	MI.10024	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	794	265	P	H	cCt/cAt	4.29	0.99	0	probably_damaging	1	neutral	0.54	neutral	1.12	deleterious	-9.43	deleterious	-6.75	high_impact	5.31	0.88	neutral	0.32	neutral	3.99	23.60	deleterious	0.04	0.35	0.8	disease	0.82	disease	0.77	disease	0.76	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.26	medium_impact	3.63	high_impact	0.29	0.8	59.74	8.69	0.63	P	0.71	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15542	15542	C	T	MI.10025	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	796	266	P	S	Ccc/Tcc	-20	0	0	probably_damaging	1	neutral	0.39	neutral	3.11	neutral	-0.69	deleterious	-5.51	medium_impact	3.19	0.81	neutral	0.48	neutral	3.63	23.20	deleterious	0.21	0.45	0.37	neutral	0.73	disease	0.46	neutral	0.48	neutral	0	1	deleterious	0.2	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	0.12	medium_impact	1.7	medium_impact	0.13	0.8	17.37	23.08	0.28	N	0.90	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15542	15542	C	G	MI.10026	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	796	266	P	A	Ccc/Gcc	-20	0	0	probably_damaging	0.98	neutral	0.51	neutral	3.21	neutral	0.58	deleterious	-5.42	low_impact	1.62	0.88	neutral	0.67	neutral	0.34	6.12	deleterious	0.16	0.45	0.25	neutral	0.5	disease	0.33	neutral	0.4	neutral	2	0.97	neutral	0.27	neutral	-2	neutral	0.70	deleterious	-2.31	low_impact	0.23	medium_impact	0.28	medium_impact	0.62	0.8	17.37	23.08	0.36	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15542	15542	C	A	MI.10027	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	796	266	P	T	Ccc/Acc	-20	0	0	probably_damaging	1	neutral	0.41	neutral	3.13	neutral	-1.08	deleterious	-5.45	medium_impact	2.27	0.81	neutral	0.44	neutral	3.42	23.00	deleterious	0.18	0.45	0.41	neutral	0.74	disease	0.26	neutral	0.46	neutral	1	1	deleterious	0.21	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	0.14	medium_impact	0.87	medium_impact	0.58	0.8	17.37	23.08	0.28	N	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15543	15543	C	G	MI.10028	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	797	266	P	R	cCc/cGc	2.69	0.86	0	probably_damaging	1	neutral	0.34	neutral	3.1	neutral	-1.58	deleterious	-6.3	high_impact	3.94	0.83	neutral	0.33	neutral	3.67	23.30	deleterious	0.08	0.35	0.43	neutral	0.84	disease	0.57	disease	0.67	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.07	medium_impact	2.38	high_impact	0.34	0.8	17.37	23.08	0.36	N	0.80	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15543	15543	C	T	MI.10029	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	797	266	P	L	cCc/cTc	2.69	0.86	0	probably_damaging	1	neutral	0.67	neutral	3.22	neutral	-1.15	deleterious	-6.87	medium_impact	2.17	0.88	neutral	0.39	neutral	4.33	24.00	deleterious	0.14	0.4	0.29	neutral	0.81	disease	0.36	neutral	0.6	disease	2	1	deleterious	0.34	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	0.39	medium_impact	0.78	medium_impact	0.62	0.8	17.37	23.08	0.25	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8996	8996	C	G	MI.1003	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	470	157	A	G	gCc/gGc	9.15	1	0	probably_damaging	0.99	neutral	1	neutral	3.84	neutral	-0.39	neutral	-0.45	neutral_impact	-1.14	0.81	neutral	0.59	neutral	1.33	12.42	neutral	0.25	0.65	0.31	neutral	0.16	neutral	0.29	neutral	0.23	neutral	5	0.99	deleterious	0.51	deleterious	-2	neutral	0.68	deleterious	-2.65	low_impact	1.98	high_impact	-2.07	low_impact	0.79	0.9	48.67	9	0.44	N	0.86	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15543	15543	C	A	MI.10030	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	797	266	P	H	cCc/cAc	2.69	0.86	0	probably_damaging	1	neutral	0.55	neutral	3.08	neutral	-2.47	deleterious	-6.32	high_impact	4.08	0.78	neutral	0.31	neutral	4.06	23.70	deleterious	0.1	0.4	0.59	disease	0.81	disease	0.62	disease	0.65	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.27	medium_impact	2.51	high_impact	0.25	0.8	17.37	23.08	0.27	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15545	15545	C	G	MI.10031	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	799	267	H	D	Cac/Gac	-11.98	0	0	probably_damaging	0.99	neutral	0.2	neutral	2.67	neutral	-2.37	deleterious	-6.71	high_impact	4.24	0.92	neutral	0.34	neutral	2.29	18.13	deleterious	0.05	0.35	0.48	neutral	0.81	disease	0.82	disease	0.76	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	-0.1	medium_impact	2.66	high_impact	0.20	0.8	57.89	8.59	0.5	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15545	15545	C	A	MI.10032	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	799	267	H	N	Cac/Aac	-11.98	0	0	probably_damaging	0.98	neutral	0.31	neutral	2.66	neutral	-2.61	deleterious	-5.21	high_impact	4.24	0.93	neutral	0.42	neutral	2.23	17.73	deleterious	0.16	0.45	0.48	neutral	0.85	disease	0.79	disease	0.74	disease	5	0.98	deleterious	0.17	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0.03	medium_impact	2.66	high_impact	0.17	0.8	57.89	8.59	0.51	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15545	15545	C	T	MI.10033	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	799	267	H	Y	Cac/Tac	-11.98	0	0	probably_damaging	0.97	neutral	1	neutral	2.6	deleterious	-4.64	deleterious	-4.47	high_impact	4.72	0.94	neutral	0.37	neutral	2.04	16.47	deleterious	0.09	0.35	0.72	disease	0.85	disease	0.75	disease	0.75	disease	5	0.97	neutral	0.52	deleterious	2	deleterious	0.83	deleterious	-2.14	low_impact	1.85	high_impact	3.09	high_impact	0.17	0.8	57.89	8.59	0.64	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15546	15546	A	T	MI.10034	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	800	267	H	L	cAc/cTc	7.04	1	0	probably_damaging	0.97	neutral	0.65	neutral	2.62	deleterious	-3.42	deleterious	-8.2	high_impact	4.03	0.95	neutral	0.37	neutral	2.25	17.81	deleterious	0.04	0.35	0.55	disease	0.89	disease	0.78	disease	0.77	disease	5	0.97	neutral	0.34	neutral	2	deleterious	0.81	deleterious	-2.14	low_impact	0.37	medium_impact	2.47	high_impact	0.15	0.8	57.89	8.59	0.6	P	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15546	15546	A	G	MI.10035	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	800	267	H	R	cAc/cGc	7.04	1	0	probably_damaging	0.97	neutral	0.35	neutral	2.65	neutral	-2.79	deleterious	-5.96	high_impact	4.72	0.94	neutral	0.32	neutral	1.34	12.46	neutral	0.06	0.35	0.47	neutral	0.86	disease	0.77	disease	0.74	disease	5	0.97	neutral	0.19	neutral	2	deleterious	0.82	deleterious	-2.14	low_impact	0.08	medium_impact	3.09	high_impact	0.16	0.8	57.89	8.59	0.73	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15546	15546	A	C	MI.10036	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	800	267	H	P	cAc/cCc	7.04	1	0	probably_damaging	0.99	neutral	0.21	neutral	2.6	deleterious	-4.19	deleterious	-7.47	high_impact	5.28	0.94	neutral	0.27	damaging	1.68	14.29	neutral	0.03	0.35	0.48	neutral	0.87	disease	0.76	disease	0.74	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	-0.09	medium_impact	3.6	high_impact	0.12	0.8	57.89	8.59	0.69	P	0.99	polymorphism	1	0.12	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15547	15547	C	A	MI.10037	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	801	267	H	Q	caC/caA	8.42	1	0	probably_damaging	0.98	neutral	0.29	neutral	2.65	neutral	-2.65	deleterious	-5.96	high_impact	4.58	0.95	neutral	0.35	neutral	2.25	17.84	deleterious	0.09	0.35	0.37	neutral	0.82	disease	0.77	disease	0.74	disease	5	0.98	deleterious	0.16	neutral	2	deleterious	0.76	deleterious	-2.31	low_impact	0.01	medium_impact	2.97	high_impact	0.24	0.8	57.89	8.59	0.62	P	0.94	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15547	15547	C	G	MI.10038	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	801	267	H	Q	caC/caG	8.42	1	0	probably_damaging	0.98	neutral	0.29	neutral	2.65	neutral	-2.65	deleterious	-5.96	high_impact	4.58	0.95	neutral	0.35	neutral	1.85	15.28	deleterious	0.09	0.35	0.37	neutral	0.82	disease	0.77	disease	0.74	disease	5	0.98	deleterious	0.16	neutral	2	deleterious	0.76	deleterious	-2.31	low_impact	0.01	medium_impact	2.97	high_impact	0.24	0.8	57.89	8.59	0.61	P	0.94	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15548	15548	A	T	MI.10039	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	802	268	I	F	Atc/Ttc	-5.33	0	0	probably_damaging	0.99	neutral	0.7	neutral	1.98	deleterious	-5.6	deleterious	-2.93	high_impact	4.79	0.95	neutral	0.1	damaging	2.06	16.61	deleterious	0.06	0.35	0.86	disease	0.82	disease	0.78	disease	0.8	disease	6	0.98	deleterious	0.36	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	0.42	medium_impact	3.16	high_impact	0.54	0.8	58.42	8.75	0.69	P	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8998	8998	G	A	MI.1004	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	472	158	V	M	Gta/Ata	-10.98	0	0	possibly_damaging	0.55	deleterious	0.01	neutral	3.62	neutral	-2.61	deleterious	-2.65	medium_impact	3.32	0.89	neutral	0.65	neutral	3.41	23.00	deleterious	0.4	0.65	0.64	disease	0.86	disease	0.55	disease	0.69	disease	4	0.99	deleterious	0.23	neutral	4	deleterious	0.57	deleterious	-0.84	medium_impact	-0.84	medium_impact	1.75	medium_impact	0.85	0.9	48.67	8.64	0.46	N	0.96	polymorphism	0.6	0.12	rs376792657	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15548	15548	A	G	MI.10040	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	802	268	I	V	Atc/Gtc	-5.33	0	0	possibly_damaging	0.81	neutral	0.5	neutral	2.2	neutral	-2.47	neutral	-0.73	high_impact	4.29	0.95	neutral	0.13	damaging	1.14	11.42	neutral	0.29	0.45	0.45	neutral	0.49	neutral	0.69	disease	0.59	disease	2	0.79	neutral	0.35	neutral	1	deleterious	0.49	deleterious	-1.32	low_impact	0.22	medium_impact	2.7	high_impact	0.36	0.8	58.42	8.75	0.37	N	0.83	polymorphism	1	0.06	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15548	15548	A	C	MI.10041	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	802	268	I	L	Atc/Ctc	-5.33	0	0	probably_damaging	0.92	neutral	0.65	neutral	2.11	deleterious	-3.21	neutral	-1.47	high_impact	4.64	0.96	neutral	0.09	damaging	1.89	15.51	deleterious	0.15	0.4	0.59	disease	0.69	disease	0.74	disease	0.73	disease	5	0.91	neutral	0.37	neutral	2	deleterious	0.58	deleterious	-1.72	low_impact	0.37	medium_impact	3.02	high_impact	0.48	0.8	58.42	8.75	0.45	N	0.88	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15549	15549	T	A	MI.10042	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	803	268	I	N	aTc/aAc	6.81	1	0	probably_damaging	1	neutral	0.31	neutral	1.96	deleterious	-7.3	deleterious	-5.14	high_impact	5.33	0.94	neutral	0.1	damaging	4.24	23.90	deleterious	0.06	0.35	0.95	disease	0.88	disease	0.77	disease	0.84	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.03	medium_impact	3.65	high_impact	0.44	0.8	58.42	8.75	0.77	P	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15549	15549	T	C	MI.10043	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	803	268	I	T	aTc/aCc	6.81	1	0	probably_damaging	0.99	neutral	0.39	neutral	1.99	deleterious	-5.09	deleterious	-3.65	high_impact	5.33	0.94	neutral	0.09	damaging	1.90	15.59	deleterious	0.04	0.35	0.85	disease	0.83	disease	0.76	disease	0.8	disease	6	0.99	deleterious	0.2	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0.12	medium_impact	3.65	high_impact	0.41	0.8	58.42	8.75	0.76	P	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15549	15549	T	G	MI.10044	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	803	268	I	S	aTc/aGc	6.81	1	0	probably_damaging	0.99	neutral	0.4	neutral	1.97	deleterious	-6.23	deleterious	-4.38	high_impact	5.33	0.94	neutral	0.1	damaging	4.01	23.60	deleterious	0.03	0.35	0.91	disease	0.86	disease	0.77	disease	0.82	disease	6	0.99	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0.13	medium_impact	3.65	high_impact	0.30	0.8	58.42	8.75	0.79	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15550	15550	C	A	MI.10045	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	804	268	I	M	atC/atA	7.27	1	0	probably_damaging	1	neutral	0.22	neutral	2	deleterious	-4.91	neutral	-2.2	high_impact	4.43	0.95	neutral	0.09	damaging	2.26	17.92	deleterious	0.11	0.4	0.83	disease	0.65	disease	0.67	disease	0.63	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.08	medium_impact	2.83	high_impact	0.61	0.8	58.42	8.75	0.55	P	0.83	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15550	15550	C	G	MI.10046	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	804	268	I	M	atC/atG	7.27	1	0	probably_damaging	1	neutral	0.22	neutral	2	deleterious	-4.91	neutral	-2.2	high_impact	4.43	0.95	neutral	0.09	damaging	1.78	14.87	neutral	0.11	0.4	0.83	disease	0.65	disease	0.67	disease	0.63	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.08	medium_impact	2.83	high_impact	0.61	0.8	58.42	8.75	0.55	P	0.83	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15551	15551	A	G	MI.10047	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	805	269	K	E	Aag/Gag	-5.1	0	0	probably_damaging	0.99	neutral	0.29	neutral	3.05	neutral	-0.88	neutral	-2.16	medium_impact	3.28	0.92	neutral	0.14	damaging	3.79	23.40	deleterious	0.1	0.4	0.43	neutral	0.84	disease	0.75	disease	0.77	disease	5	0.99	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-2.59	low_impact	0.01	medium_impact	1.79	medium_impact	0.57	0.8	56.58	8.55	0.38	N	0.95	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15551	15551	A	C	MI.10048	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	805	269	K	Q	Aag/Cag	-5.1	0	0	probably_damaging	0.99	neutral	0.29	neutral	3.11	neutral	-0.09	neutral	-1.68	low_impact	1.07	0.9	neutral	0.13	damaging	1.93	15.79	deleterious	0.22	0.45	0.43	neutral	0.61	disease	0.36	neutral	0.43	neutral	1	0.99	deleterious	0.15	neutral	-2	neutral	0.75	deleterious	-2.59	low_impact	0.01	medium_impact	-0.22	medium_impact	0.36	0.8	56.58	8.55	0.34	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15552	15552	A	C	MI.10049	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	806	269	K	T	aAg/aCg	6.81	1	0	probably_damaging	1	neutral	0.38	neutral	3.05	neutral	-0.97	deleterious	-3.66	high_impact	4	0.91	neutral	0.14	damaging	3.71	23.30	deleterious	0.05	0.35	0.42	neutral	0.86	disease	0.72	disease	0.76	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.11	medium_impact	2.44	high_impact	0.17	0.8	56.58	8.55	0.57	P	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8998	8998	G	C	MI.1005	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	472	158	V	L	Gta/Cta	-10.98	0	0	benign	0.07	neutral	0.15	neutral	4.17	neutral	0.61	deleterious	-2.62	low_impact	1.55	0.75	neutral	0.56	neutral	1.80	14.97	neutral	0.32	0.65	0.4	neutral	0.81	disease	0.35	neutral	0.49	neutral	0	0.84	neutral	0.54	deleterious	-6	neutral	0.26	neutral	0.31	medium_impact	-0.13	medium_impact	0.23	medium_impact	0.65	0.9	48.67	8.64	0.42	N	0.70	polymorphism	0.64	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15552	15552	A	T	MI.10050	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	806	269	K	M	aAg/aTg	6.81	1	0	probably_damaging	1	neutral	0.2	neutral	3.02	neutral	-2.25	deleterious	-3.34	high_impact	4.14	0.91	neutral	0.15	damaging	4.13	23.80	deleterious	0.05	0.35	0.55	disease	0.78	disease	0.62	disease	0.66	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	-0.1	medium_impact	2.57	high_impact	0.13	0.8	56.58	8.55	0.57	P	0.67	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15553	15553	G	C	MI.10051	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	807	269	K	N	aaG/aaC	8.42	1	0	probably_damaging	1	neutral	0.28	neutral	3.01	neutral	-1.75	deleterious	-3	high_impact	4.7	0.88	neutral	0.13	damaging	3.94	23.50	deleterious	0.23	0.45	0.52	disease	0.85	disease	0.65	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0	medium_impact	3.07	high_impact	0.34	0.8	56.58	8.55	0.65	P	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15553	15553	G	T	MI.10052	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	807	269	K	N	aaG/aaT	8.42	1	0	probably_damaging	1	neutral	0.28	neutral	3.01	neutral	-1.75	deleterious	-3	high_impact	4.7	0.88	neutral	0.13	damaging	4.05	23.70	deleterious	0.23	0.45	0.52	disease	0.85	disease	0.65	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0	medium_impact	3.07	high_impact	0.34	0.8	56.58	8.55	0.65	P	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15554	15554	C	A	MI.10053	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	808	270	P	T	Ccc/Acc	0.4	0.98	0	probably_damaging	1	neutral	0.39	neutral	0.42	deleterious	-8.64	deleterious	-5.8	high_impact	5.34	0.92	neutral	0.11	damaging	3.85	23.40	deleterious	0.06	0.35	0.72	disease	0.85	disease	0.72	disease	0.74	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.12	medium_impact	3.66	high_impact	0.55	0.8	58.68	8.76	0.61	P	0.96	polymorphism	1	0.17	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15554	15554	C	T	MI.10054	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	808	270	P	S	Ccc/Tcc	0.4	0.98	0	probably_damaging	1	neutral	0.4	neutral	0.43	deleterious	-8.2	deleterious	-5.8	high_impact	4.8	0.93	neutral	0.1	damaging	3.85	23.40	deleterious	0.07	0.35	0.45	neutral	0.81	disease	0.7	disease	0.73	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.13	medium_impact	3.17	high_impact	0.22	0.8	58.68	8.76	0.6	P	0.90	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15554	15554	C	G	MI.10055	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	808	270	P	A	Ccc/Gcc	0.4	0.98	0	probably_damaging	0.99	neutral	0.51	neutral	0.44	deleterious	-7.91	deleterious	-5.79	high_impact	5.34	0.94	neutral	0.15	damaging	2.84	21.60	deleterious	0.07	0.35	0.47	neutral	0.67	disease	0.7	disease	0.71	disease	4	0.99	deleterious	0.26	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.23	medium_impact	3.66	high_impact	0.63	0.8	58.68	8.76	0.58	P	0.84	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15555	15555	C	A	MI.10056	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	809	270	P	H	cCc/cAc	5.44	1	0	probably_damaging	1	neutral	0.53	neutral	0.41	deleterious	-10.26	deleterious	-6.55	high_impact	5.34	0.91	neutral	0.09	damaging	4.06	23.70	deleterious	0.05	0.35	0.93	disease	0.85	disease	0.79	disease	0.86	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.25	medium_impact	3.66	high_impact	0.28	0.8	58.68	8.76	0.68	P	0.71	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15555	15555	C	G	MI.10057	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	809	270	P	R	cCc/cGc	5.44	1	0	probably_damaging	1	neutral	0.34	neutral	0.42	deleterious	-9.21	deleterious	-6.55	high_impact	5.34	0.93	neutral	0.08	damaging	3.66	23.20	deleterious	0.03	0.35	0.85	disease	0.89	disease	0.81	disease	0.83	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.07	medium_impact	3.66	high_impact	0.28	0.8	58.68	8.76	0.7	P	0.80	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15555	15555	C	T	MI.10058	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	809	270	P	L	cCc/cTc	5.44	1	0	probably_damaging	1	neutral	0.64	neutral	0.42	deleterious	-9.09	deleterious	-7.29	high_impact	5.34	0.94	neutral	0.07	damaging	4.48	24.30	deleterious	0.05	0.35	0.87	disease	0.87	disease	0.68	disease	0.78	disease	6	1	deleterious	0.32	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.36	medium_impact	3.66	high_impact	0.55	0.8	58.68	8.76	0.69	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15557	15557	G	A	MI.10059	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	811	271	E	K	Gaa/Aaa	-1.67	0	0	probably_damaging	1	neutral	0.3	neutral	2.32	deleterious	-4.18	deleterious	-2.81	high_impact	4.56	0.87	neutral	0.08	damaging	4.42	24.20	deleterious	0.06	0.35	0.75	disease	0.88	disease	0.8	disease	0.78	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.02	medium_impact	2.95	high_impact	0.58	0.8	58.16	8.82	0.57	N	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8998	8998	G	T	MI.1006	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	472	158	V	L	Gta/Tta	-10.98	0	0	benign	0.07	neutral	0.15	neutral	4.17	neutral	0.61	deleterious	-2.62	low_impact	1.55	0.75	neutral	0.56	neutral	1.90	15.60	deleterious	0.32	0.65	0.4	neutral	0.81	disease	0.35	neutral	0.49	neutral	0	0.84	neutral	0.54	deleterious	-6	neutral	0.26	neutral	0.31	medium_impact	-0.13	medium_impact	0.23	medium_impact	0.65	0.9	48.67	8.64	0.42	N	0.70	polymorphism	0.64	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15557	15557	G	C	MI.10060	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	811	271	E	Q	Gaa/Caa	-1.67	0	0	probably_damaging	1	neutral	0.3	neutral	2.31	deleterious	-4.46	neutral	-2.1	high_impact	4.56	0.85	neutral	0.11	damaging	3.33	22.90	deleterious	0.14	0.4	0.79	disease	0.79	disease	0.77	disease	0.78	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.02	medium_impact	2.95	high_impact	0.62	0.8	58.16	8.82	0.55	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15558	15558	A	G	MI.10061	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	812	271	E	G	gAa/gGa	5.9	1	0	probably_damaging	1	neutral	0.33	neutral	2.28	deleterious	-5.67	deleterious	-4.91	high_impact	5.25	0.92	neutral	0.14	damaging	4.33	24.00	deleterious	0.04	0.35	0.83	disease	0.79	disease	0.77	disease	0.78	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.06	medium_impact	3.57	high_impact	0.27	0.8	58.16	8.82	0.77	P	0.77	polymorphism	1	0.25	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15558	15558	A	T	MI.10062	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	812	271	E	V	gAa/gTa	5.9	1	0	probably_damaging	1	neutral	0.5	neutral	2.31	deleterious	-4.46	deleterious	-4.91	medium_impact	3.03	0.86	neutral	0.12	damaging	4.20	23.90	deleterious	0.03	0.35	0.88	disease	0.89	disease	0.79	disease	0.82	disease	6	1	deleterious	0.25	neutral	1	deleterious	0.91	deleterious	-3.53	low_impact	0.22	medium_impact	1.56	medium_impact	0.38	0.8	58.16	8.82	0.57	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15558	15558	A	C	MI.10063	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	812	271	E	A	gAa/gCa	5.9	1	0	probably_damaging	1	neutral	0.53	neutral	2.3	deleterious	-4.56	deleterious	-4.19	high_impact	5.25	0.87	neutral	0.15	damaging	3.68	23.30	deleterious	0.05	0.35	0.79	disease	0.75	disease	0.78	disease	0.78	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.25	medium_impact	3.57	high_impact	0.36	0.8	58.16	8.82	0.77	P	0.82	polymorphism	1	0.15	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15559	15559	A	C	MI.10064	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	813	271	E	D	gaA/gaC	6.81	1	0	probably_damaging	0.99	neutral	0.21	neutral	2.52	neutral	-2.1	neutral	-2.11	high_impact	4.91	0.83	neutral	0.1	damaging	2.20	17.49	deleterious	0.22	0.45	0.67	disease	0.75	disease	0.74	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	-0.09	medium_impact	3.26	high_impact	0.55	0.8	58.16	8.82	0.77	P	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15559	15559	A	T	MI.10065	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	813	271	E	D	gaA/gaT	6.81	1	0	probably_damaging	0.99	neutral	0.21	neutral	2.52	neutral	-2.1	neutral	-2.11	high_impact	4.91	0.83	neutral	0.1	damaging	2.23	17.73	deleterious	0.22	0.45	0.67	disease	0.75	disease	0.74	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	-0.09	medium_impact	3.26	high_impact	0.55	0.8	58.16	8.82	0.77	P	0.91	polymorphism	1	0.04	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15560	15560	T	G	MI.10066	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	814	272	W	G	Tga/Gga	-0.29	0.24	0	benign	0	neutral	0.33	neutral	0.15	deleterious	-11.11	deleterious	-9.07	high_impact	5.34	0.81	neutral	0.13	damaging	3.79	23.40	deleterious	0.03	0.35	0.92	disease	0.86	disease	0.75	disease	0.84	disease	7	0.67	neutral	0.67	deleterious	-2	neutral	0.33	neutral	2.07	high_impact	0.06	medium_impact	3.66	high_impact	0.07	0.8	57.63	8.71	0.5	N	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15560	15560	T	C	MI.10067	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	814	272	W	R	Tga/Cga	-0.29	0.24	0	possibly_damaging	0.9	neutral	0.35	neutral	0.15	deleterious	-10.59	deleterious	-9.77	high_impact	4.8	0.78	neutral	0.06	damaging	3.68	23.30	deleterious	0.02	0.35	0.91	disease	0.92	disease	0.79	disease	0.86	disease	7	0.91	neutral	0.23	neutral	1	deleterious	0.87	deleterious	-1.62	low_impact	0.08	medium_impact	3.17	high_impact	0.08	0.8	57.63	8.71	0.52	P	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15561	15561	G	C	MI.10068	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	815	272	W	S	tGa/tCa	7.27	1	0	possibly_damaging	0.48	neutral	0.4	neutral	0.15	deleterious	-11.07	deleterious	-9.74	high_impact	5	0.85	neutral	0.09	damaging	3.96	23.60	deleterious	0.03	0.35	0.89	disease	0.91	disease	0.74	disease	0.82	disease	6	0.57	neutral	0.46	neutral	1	deleterious	0.70	deleterious	-0.7	medium_impact	0.13	medium_impact	3.35	high_impact	0.06	0.8	57.63	8.71	0.55	P	0.99	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15561	15561	G	T	MI.10069	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	815	272	W	L	tGa/tTa	7.27	1	0	possibly_damaging	0.64	neutral	0.65	neutral	0.17	deleterious	-8.72	deleterious	-9.07	high_impact	5	0.85	neutral	0.07	damaging	4.16	23.80	deleterious	0.03	0.35	0.66	disease	0.88	disease	0.74	disease	0.77	disease	5	0.57	neutral	0.51	deleterious	1	deleterious	0.75	deleterious	-0.96	medium_impact	0.37	medium_impact	3.35	high_impact	0.08	0.8	57.63	8.71	0.6	P	0.99	polymorphism	1	0.27	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8999	8999	T	G	MI.1007	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	473	158	V	G	gTa/gGa	2.44	0.99	0	benign	0.11	deleterious	0	neutral	3.55	deleterious	-6.14	deleterious	-6.28	high_impact	4.29	0.89	neutral	0.66	neutral	2.03	16.38	deleterious	0.15	0.65	0.96	disease	0.88	disease	0.64	disease	0.82	disease	6	1	deleterious	0.45	neutral	2	deleterious	0.37	neutral	0.11	medium_impact	-1.4	low_impact	2.58	high_impact	0.42	0.9	48.67	8.64	0.47	N	0.93	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15562	15562	A	C	MI.10070	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	816	272	W	C	tgA/tgC	7.27	1	0.01	probably_damaging	0.95	neutral	0.18	neutral	0.15	deleterious	-12.17	deleterious	-9.09	high_impact	5.34	0.83	neutral	0.05	damaging	4.12	23.80	deleterious	0.03	0.35	0.95	disease	0.9	disease	0.79	disease	0.84	disease	7	0.97	neutral	0.12	neutral	2	deleterious	0.87	deleterious	-1.92	low_impact	-0.14	medium_impact	3.66	high_impact	0.13	0.8	57.63	8.71	0.53	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15562	15562	A	T	MI.10071	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	816	272	W	C	tgA/tgT	7.27	1	0.01	probably_damaging	0.95	neutral	0.18	neutral	0.15	deleterious	-12.17	deleterious	-9.09	high_impact	5.34	0.83	neutral	0.05	damaging	4.19	23.80	deleterious	0.03	0.35	0.95	disease	0.9	disease	0.79	disease	0.84	disease	7	0.97	neutral	0.12	neutral	2	deleterious	0.87	deleterious	-1.92	low_impact	-0.14	medium_impact	3.66	high_impact	0.13	0.8	57.63	8.71	0.53	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15563	15563	T	C	MI.10072	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	817	273	Y	H	Tat/Cat	0.17	0.92	0	probably_damaging	1	neutral	0.4	neutral	1.48	deleterious	-6.35	deleterious	-3.5	high_impact	5	0.85	neutral	0.09	damaging	3.68	23.30	deleterious	0.13	0.4	0.87	disease	0.81	disease	0.82	disease	0.82	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.13	medium_impact	3.35	high_impact	0.17	0.8	56.84	8.69	0.73	P	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15563	15563	T	A	MI.10073	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	817	273	Y	N	Tat/Aat	0.17	0.92	0	probably_damaging	1	neutral	0.21	neutral	1.46	deleterious	-7.65	deleterious	-6.29	high_impact	5	0.86	neutral	0.13	damaging	4.20	23.90	deleterious	0.06	0.35	0.86	disease	0.88	disease	0.76	disease	0.81	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.09	medium_impact	3.35	high_impact	0.12	0.8	56.84	8.69	0.64	P	0.99	polymorphism	1	0.26	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15563	15563	T	G	MI.10074	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	817	273	Y	D	Tat/Gat	0.17	0.92	0	probably_damaging	1	neutral	0.14	neutral	1.45	deleterious	-8.74	deleterious	-6.99	high_impact	5.34	0.83	neutral	0.1	damaging	4.13	23.80	deleterious	0.04	0.35	0.9	disease	0.87	disease	0.81	disease	0.83	disease	7	1	deleterious	0.07	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.21	medium_impact	3.66	high_impact	0.09	0.8	56.84	8.69	0.61	P	1.00	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15564	15564	A	T	MI.10075	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	818	273	Y	F	tAt/tTt	5.67	1	0	probably_damaging	1	neutral	0.62	neutral	1.62	deleterious	-4.16	deleterious	-2.79	high_impact	5	0.87	neutral	0.11	damaging	3.04	22.40	deleterious	0.18	0.45	0.69	disease	0.81	disease	0.71	disease	0.73	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.34	medium_impact	3.35	high_impact	0.40	0.8	56.84	8.69	0.73	P	0.83	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15564	15564	A	C	MI.10076	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	818	273	Y	S	tAt/tCt	5.67	1	0	probably_damaging	1	neutral	0.35	neutral	1.46	deleterious	-7.64	deleterious	-6.27	high_impact	5	0.85	neutral	0.11	damaging	3.67	23.20	deleterious	0.05	0.35	0.73	disease	0.84	disease	0.77	disease	0.75	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.08	medium_impact	3.35	high_impact	0.15	0.8	56.84	8.69	0.72	P	1.00	polymorphism	1	0.26	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15564	15564	A	G	MI.10077	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	818	273	Y	C	tAt/tGt	5.67	1	0	probably_damaging	1	neutral	0.16	neutral	1.45	deleterious	-8.21	deleterious	-6.31	high_impact	5.34	0.91	neutral	0.07	damaging	3.49	23.10	deleterious	0.05	0.35	0.89	disease	0.85	disease	0.78	disease	0.81	disease	6	1	deleterious	0.08	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.17	medium_impact	3.66	high_impact	0.08	0.8	56.84	8.69	0.7	P	1.00	polymorphism	1	0.26	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15566	15566	T	C	MI.10078	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	820	274	F	L	Ttc/Ctc	-3.27	0	0	benign	0.01	neutral	0.57	neutral	2.17	neutral	-2.86	deleterious	-4.18	medium_impact	3.42	0.97	neutral	0.12	damaging	3.92	23.50	deleterious	0.06	0.35	0.23	neutral	0.81	disease	0.61	disease	0.67	disease	3	0.41	neutral	0.78	deleterious	-3	neutral	0.22	neutral	1.13	medium_impact	0.29	medium_impact	1.91	medium_impact	0.43	0.8	58.42	8.71	0.25	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15566	15566	T	A	MI.10079	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	820	274	F	I	Ttc/Atc	-3.27	0	0	benign	0.25	neutral	0.43	neutral	1.99	deleterious	-4.74	deleterious	-4.18	high_impact	5.28	0.94	neutral	0.12	damaging	4.48	24.20	deleterious	0.06	0.35	0.34	neutral	0.81	disease	0.67	disease	0.69	disease	4	0.48	neutral	0.59	deleterious	-2	neutral	0.52	deleterious	-0.29	medium_impact	0.16	medium_impact	3.6	high_impact	0.38	0.8	58.42	8.71	0.6	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8999	8999	T	A	MI.1008	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	473	158	V	E	gTa/gAa	2.44	0.99	0	benign	0.17	deleterious	0	neutral	3.55	deleterious	-6.25	deleterious	-5.39	high_impact	4.29	0.8	neutral	0.54	neutral	2.88	21.80	deleterious	0.11	0.65	0.96	disease	0.93	disease	0.72	disease	0.83	disease	7	1	deleterious	0.42	neutral	2	deleterious	0.47	deleterious	-0.1	medium_impact	-1.4	low_impact	2.58	high_impact	0.48	0.9	48.67	8.64	0.43	N	0.98	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15566	15566	T	G	MI.10080	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	820	274	F	V	Ttc/Gtc	-3.27	0	0	possibly_damaging	0.55	neutral	0.25	neutral	1.96	deleterious	-5.5	deleterious	-4.88	high_impact	5.28	0.95	neutral	0.11	damaging	4.22	23.90	deleterious	0.04	0.35	0.45	neutral	0.86	disease	0.68	disease	0.73	disease	5	0.74	neutral	0.35	neutral	1	deleterious	0.58	deleterious	-0.81	medium_impact	-0.04	medium_impact	3.6	high_impact	0.31	0.8	58.42	8.71	0.62	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15567	15567	T	A	MI.10081	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	821	274	F	Y	tTc/tAc	7.27	1	0	possibly_damaging	0.6	neutral	1	neutral	2.04	deleterious	-4	neutral	-2.09	medium_impact	3.49	0.95	neutral	0.11	damaging	3.93	23.50	deleterious	0.09	0.35	0.71	disease	0.78	disease	0.59	disease	0.67	disease	3	0.6	neutral	0.7	deleterious	0	NA	0.71	deleterious	-0.9	medium_impact	1.85	high_impact	1.98	medium_impact	0.44	0.8	58.42	8.71	0.48	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15567	15567	T	C	MI.10082	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	821	274	F	S	tTc/tCc	7.27	1	0	possibly_damaging	0.9	neutral	0.31	neutral	1.93	deleterious	-7.3	deleterious	-5.56	high_impact	4.93	0.93	neutral	0.08	damaging	4.23	23.90	deleterious	0.02	0.35	0.68	disease	0.84	disease	0.67	disease	0.72	disease	4	0.92	neutral	0.21	neutral	1	deleterious	0.81	deleterious	-1.62	low_impact	0.03	medium_impact	3.28	high_impact	0.22	0.8	58.42	8.71	0.66	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15567	15567	T	G	MI.10083	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	821	274	F	C	tTc/tGc	7.27	1	0	probably_damaging	0.98	neutral	0.09	neutral	1.92	deleterious	-8.37	deleterious	-5.6	high_impact	4.93	0.95	neutral	0.09	damaging	4.18	23.80	deleterious	0.03	0.35	0.82	disease	0.83	disease	0.68	disease	0.73	disease	5	0.99	deleterious	0.06	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	-0.32	medium_impact	3.28	high_impact	0.23	0.8	58.42	8.71	0.63	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15568	15568	C	G	MI.10084	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	822	274	F	L	ttC/ttG	4.52	1	0	benign	0.01	neutral	0.57	neutral	2.17	neutral	-2.86	deleterious	-4.18	medium_impact	3.42	0.97	neutral	0.12	damaging	4.12	23.80	deleterious	0.06	0.35	0.23	neutral	0.81	disease	0.61	disease	0.67	disease	3	0.41	neutral	0.78	deleterious	-3	neutral	0.22	neutral	1.13	medium_impact	0.29	medium_impact	1.91	medium_impact	0.43	0.8	58.42	8.71	0.43	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15568	15568	C	A	MI.10085	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	822	274	F	L	ttC/ttA	4.52	1	0	benign	0.01	neutral	0.57	neutral	2.17	neutral	-2.86	deleterious	-4.18	medium_impact	3.42	0.97	neutral	0.12	damaging	4.45	24.20	deleterious	0.06	0.35	0.23	neutral	0.81	disease	0.61	disease	0.67	disease	3	0.41	neutral	0.78	deleterious	-3	neutral	0.22	neutral	1.13	medium_impact	0.29	medium_impact	1.91	medium_impact	0.43	0.8	58.42	8.71	0.43	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15569	15569	C	A	MI.10086	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	823	275	L	M	Cta/Ata	-1.44	0	0	probably_damaging	1	neutral	0.14	neutral	2.61	neutral	-2.92	neutral	-1.39	high_impact	4.43	0.86	neutral	0.07	damaging	3.81	23.40	deleterious	0.25	0.45	0.72	disease	0.61	disease	0.55	disease	0.63	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	-0.21	medium_impact	2.83	high_impact	0.58	0.8	58.42	8.66	0.4	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15569	15569	C	G	MI.10087	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	823	275	L	V	Cta/Gta	-1.44	0	0	probably_damaging	0.99	neutral	0.34	neutral	2.66	neutral	-2.58	neutral	-2.07	high_impact	4.89	0.8	neutral	0.08	damaging	3.28	22.80	deleterious	0.19	0.45	0.6	disease	0.71	disease	0.68	disease	0.67	disease	3	0.99	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.07	medium_impact	3.25	high_impact	0.58	0.8	58.42	8.66	0.62	P	0.91	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15570	15570	T	A	MI.10088	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	824	275	L	Q	cTa/cAa	0.63	0.17	0	probably_damaging	1	neutral	0.23	neutral	2.6	deleterious	-4.79	deleterious	-4.17	high_impact	5.24	0.85	neutral	0.04	damaging	4.21	23.90	deleterious	0.03	0.35	0.83	disease	0.82	disease	0.67	disease	0.72	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.06	medium_impact	3.56	high_impact	0.23	0.8	58.42	8.66	0.65	P	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15570	15570	T	C	MI.10089	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	824	275	L	P	cTa/cCa	0.63	0.17	0	probably_damaging	1	neutral	0.24	neutral	2.6	deleterious	-5.34	deleterious	-4.88	high_impact	4.68	0.86	neutral	0.03	damaging	4.05	23.70	deleterious	0.02	0.35	0.89	disease	0.81	disease	0.77	disease	0.78	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.05	medium_impact	3.06	high_impact	0.24	0.8	58.42	8.66	0.58	N	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8999	8999	T	C	MI.1009	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	473	158	V	A	gTa/gCa	2.44	0.99	0	benign	0	neutral	0.05	neutral	3.58	deleterious	-4.13	deleterious	-3.54	high_impact	4.29	0.9	neutral	0.65	neutral	1.71	14.44	neutral	0.27	0.65	0.86	disease	0.72	disease	0.6	disease	0.73	disease	5	0.95	neutral	0.53	deleterious	-2	neutral	0.28	neutral	2.09	high_impact	-0.43	medium_impact	2.58	high_impact	0.45	0.9	48.67	8.64	0.51	P	0.60	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15570	15570	T	G	MI.10090	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	824	275	L	R	cTa/cGa	0.63	0.17	0	probably_damaging	1	neutral	0.32	neutral	2.61	deleterious	-4.44	deleterious	-4.17	high_impact	5.24	0.82	neutral	0.03	damaging	4.32	24.00	deleterious	0.02	0.35	0.81	disease	0.89	disease	0.77	disease	0.78	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.05	medium_impact	3.56	high_impact	0.13	0.8	58.42	8.66	0.72	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15572	15572	T	A	MI.10091	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	826	276	F	I	Ttc/Atc	-0.06	0.91	0	probably_damaging	1	neutral	0.53	neutral	2.93	neutral	-1.62	deleterious	-4.16	high_impact	4.5	0.87	neutral	0.12	damaging	4.28	24.00	deleterious	0.08	0.35	0.5	disease	0.85	disease	0.76	disease	0.75	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.25	medium_impact	2.89	high_impact	0.47	0.8	57.89	8.8	0.44	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15572	15572	T	C	MI.10092	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	826	276	F	L	Ttc/Ctc	-0.06	0.91	0	probably_damaging	0.99	neutral	0.98	neutral	2.98	neutral	-1.13	deleterious	-4.15	high_impact	3.9	0.92	neutral	0.1	damaging	3.71	23.30	deleterious	0.09	0.35	0.44	neutral	0.84	disease	0.7	disease	0.74	disease	5	0.99	deleterious	0.5	deleterious	2	deleterious	0.79	deleterious	-2.59	low_impact	1.14	medium_impact	2.35	high_impact	0.51	0.8	57.89	8.8	0.29	N	0.92	disease_causing_automatic	0	0.09	rs207459996	Pathogenic	Familial_colorectal_cancer	24716	MedGen:CN029768	colorectal tumor	.	.	0.3	.	.	.	.	.	.	P	.	P	damaging
chrM	15572	15572	T	G	MI.10093	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	826	276	F	V	Ttc/Gtc	-0.06	0.91	0	probably_damaging	1	neutral	0.39	neutral	2.94	neutral	-1.22	deleterious	-4.85	high_impact	4.5	0.88	neutral	0.12	damaging	4.08	23.70	deleterious	0.05	0.35	0.45	neutral	0.89	disease	0.77	disease	0.75	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.12	medium_impact	2.89	high_impact	0.31	0.8	57.89	8.8	0.52	N	0.99	polymorphism	1	0.11	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15573	15573	T	A	MI.10094	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	827	276	F	Y	tTc/tAc	7.27	1	0	probably_damaging	0.99	neutral	0.9	neutral	2.91	neutral	-2.63	neutral	-2.08	high_impact	4.24	0.88	neutral	0.12	damaging	4.08	23.70	deleterious	0.12	0.4	0.57	disease	0.83	disease	0.72	disease	0.72	disease	4	0.99	deleterious	0.46	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.74	medium_impact	2.66	high_impact	0.65	0.8	57.89	8.8	0.54	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15573	15573	T	G	MI.10095	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	827	276	F	C	tTc/tGc	7.27	1	0	probably_damaging	1	neutral	0.12	neutral	2.87	deleterious	-3.92	deleterious	-5.56	medium_impact	3.5	0.87	neutral	0.1	damaging	4.23	23.90	deleterious	0.03	0.35	0.79	disease	0.86	disease	0.73	disease	0.75	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.84	deleterious	-3.53	low_impact	-0.25	medium_impact	1.98	medium_impact	0.28	0.8	57.89	8.8	0.53	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15573	15573	T	C	MI.10096	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	827	276	F	S	tTc/tCc	7.27	1	0	probably_damaging	1	neutral	0.33	neutral	2.9	neutral	-2.17	deleterious	-5.52	high_impact	3.9	0.86	neutral	0.09	damaging	4.35	24.10	deleterious	0.02	0.35	0.52	disease	0.87	disease	0.73	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.06	medium_impact	2.35	high_impact	0.35	0.8	57.89	8.8	0.56	P	0.99	polymorphism	1	0.09	.	.	.	.	.	endometrial and ovarian tumors	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15574	15574	C	A	MI.10097	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	828	276	F	L	ttC/ttA	5.67	1	0	probably_damaging	0.99	neutral	0.98	neutral	2.98	neutral	-1.13	deleterious	-4.15	high_impact	3.9	0.92	neutral	0.1	damaging	4.36	24.10	deleterious	0.09	0.35	0.44	neutral	0.84	disease	0.7	disease	0.74	disease	5	0.99	deleterious	0.5	deleterious	2	deleterious	0.79	deleterious	-2.59	low_impact	1.14	medium_impact	2.35	high_impact	0.51	0.8	57.89	8.8	0.49	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15574	15574	C	G	MI.10098	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	828	276	F	L	ttC/ttG	5.67	1	0	probably_damaging	0.99	neutral	0.98	neutral	2.98	neutral	-1.13	deleterious	-4.15	high_impact	3.9	0.92	neutral	0.1	damaging	4.03	23.60	deleterious	0.09	0.35	0.44	neutral	0.84	disease	0.7	disease	0.74	disease	5	0.99	deleterious	0.5	deleterious	2	deleterious	0.79	deleterious	-2.59	low_impact	1.14	medium_impact	2.35	high_impact	0.51	0.8	57.89	8.8	0.48	N	0.92	polymorphism	1	0.09	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15575	15575	G	T	MI.10099	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	829	277	A	S	Gcc/Tcc	-2.58	0	0	probably_damaging	1	neutral	0.4	neutral	2.86	neutral	-0.34	neutral	-2.07	medium_impact	2.93	0.87	neutral	0.09	damaging	3.74	23.30	deleterious	0.13	0.4	0.48	neutral	0.85	disease	0.48	neutral	0.71	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.13	medium_impact	1.47	medium_impact	0.45	0.8	55.79	8.53	0.24	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8572	8572	G	C	MI.101	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	46	16	G	R	Ggc/Cgc	0.13	0.8	0.01	possibly_damaging	0.9	deleterious	0.04	neutral	4.61	neutral	-0.54	deleterious	-6.33	high_impact	3.67	0.91	neutral	0.24	damaging	3.55	23.10	deleterious	0.22	0.65	0.75	disease	0.93	disease	0.73	disease	0.81	disease	6	0.99	deleterious	0.07	neutral	5	deleterious	0.84	deleterious	-1.66	low_impact	-0.49	medium_impact	2.05	high_impact	0.69	0.9	17.26	11.64	0.4	N	0.99	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9001	9001	C	A	MI.1010	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	475	159	R	S	Cgc/Agc	-9.59	0	0	probably_damaging	0.99	deleterious	0	neutral	0.96	deleterious	-11.35	deleterious	-5.25	high_impact	4.63	0.57	damaging	0.17	damaging	4.66	24.50	deleterious	0.15	0.65	0.95	disease	0.88	disease	0.78	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.28	0.9	49.12	8.85	0.43	N	0.77	disease_causing	0.95	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15575	15575	G	C	MI.10100	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	829	277	A	P	Gcc/Ccc	-2.58	0	0	probably_damaging	1	neutral	0.21	neutral	2.81	neutral	-2.81	deleterious	-3.49	high_impact	4.12	0.88	neutral	0.04	damaging	3.88	23.50	deleterious	0.02	0.35	0.71	disease	0.88	disease	0.71	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.09	medium_impact	2.55	high_impact	0.50	0.8	55.79	8.53	0.38	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15575	15575	G	A	MI.10101	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	829	277	A	T	Gcc/Acc	-2.58	0	0	probably_damaging	1	neutral	0.39	neutral	2.86	neutral	-0.51	deleterious	-2.76	high_impact	3.69	0.87	neutral	0.11	damaging	4.30	24.00	deleterious	0.06	0.35	0.45	neutral	0.86	disease	0.5	neutral	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.12	medium_impact	2.16	high_impact	0.70	0.85	55.79	8.53	0.31	N	0.79	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15576	15576	C	A	MI.10102	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	830	277	A	D	gCc/gAc	5.9	1	0	probably_damaging	1	neutral	0.2	neutral	2.8	deleterious	-3.34	deleterious	-4.17	high_impact	5.01	0.85	neutral	0.07	damaging	4.64	24.50	deleterious	0.02	0.35	0.7	disease	0.92	disease	0.7	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.1	medium_impact	3.36	high_impact	0.23	0.8	55.79	8.53	0.72	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15576	15576	C	T	MI.10103	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	830	277	A	V	gCc/gTc	5.9	1	0	probably_damaging	1	neutral	0.5	neutral	2.95	neutral	0.56	deleterious	-2.78	medium_impact	3.44	0.93	neutral	0.11	damaging	4.55	24.40	deleterious	0.04	0.35	0.26	neutral	0.88	disease	0.52	disease	0.69	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.22	medium_impact	1.93	medium_impact	0.69	0.85	55.79	8.53	0.47	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15576	15576	C	G	MI.10104	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	830	277	A	G	gCc/gGc	5.9	1	0	probably_damaging	1	neutral	0.33	neutral	2.82	neutral	-2.29	deleterious	-2.78	high_impact	4.66	0.92	neutral	0.14	damaging	3.86	23.50	deleterious	0.11	0.4	0.4	neutral	0.81	disease	0.58	disease	0.67	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.06	medium_impact	3.04	high_impact	0.64	0.8	55.79	8.53	0.58	P	0.83	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15578	15578	T	G	MI.10105	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	832	278	Y	D	Tac/Gac	-13.12	0	0	probably_damaging	1	neutral	0.2	neutral	1.74	deleterious	-7.57	deleterious	-6.88	high_impact	5.33	0.9	neutral	0.1	damaging	4.06	23.70	deleterious	0.01	0.35	0.57	disease	0.91	disease	0.86	disease	0.8	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.1	medium_impact	3.65	high_impact	0.20	0.8	58.95	8.73	0.61	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15578	15578	T	A	MI.10106	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	832	278	Y	N	Tac/Aac	-13.12	0	0	probably_damaging	1	neutral	0.31	neutral	1.74	deleterious	-7.22	deleterious	-6.19	high_impact	5.33	0.92	neutral	0.13	damaging	4.10	23.70	deleterious	0.03	0.35	0.62	disease	0.92	disease	0.81	disease	0.77	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.03	medium_impact	3.65	high_impact	0.18	0.8	58.95	8.73	0.64	P	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15578	15578	T	C	MI.10107	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	832	278	Y	H	Tac/Cac	-13.12	0	0	probably_damaging	1	neutral	0.53	neutral	1.77	deleterious	-5.9	deleterious	-3.44	high_impact	4.78	0.92	neutral	0.09	damaging	3.66	23.20	deleterious	0.09	0.35	0.58	disease	0.85	disease	0.88	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.25	medium_impact	3.15	high_impact	0.26	0.8	58.95	8.73	0.65	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15579	15579	A	C	MI.10108	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	833	278	Y	S	tAc/tCc	5.67	1	0	probably_damaging	1	neutral	0.4	neutral	1.74	deleterious	-7.28	deleterious	-6.17	high_impact	4.99	0.92	neutral	0.11	damaging	3.82	23.40	deleterious	0.03	0.35	0.54	disease	0.9	disease	0.81	disease	0.77	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.13	medium_impact	3.34	high_impact	0.30	0.8	58.95	8.73	0.72	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15579	15579	A	T	MI.10109	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	833	278	Y	F	tAc/tTc	5.67	1	0	probably_damaging	1	neutral	0.7	neutral	1.96	deleterious	-3.27	deleterious	-2.75	high_impact	3.64	0.94	neutral	0.11	damaging	3.27	22.80	deleterious	0.15	0.4	0.48	neutral	0.86	disease	0.8	disease	0.73	disease	5	1	deleterious	0.35	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.42	medium_impact	2.11	high_impact	0.42	0.8	58.95	8.73	0.57	P	0.83	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9001	9001	C	G	MI.1011	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	475	159	R	G	Cgc/Ggc	-9.59	0	0	probably_damaging	0.99	deleterious	0	neutral	0.96	deleterious	-11.14	deleterious	-6.2	high_impact	4.63	0.57	damaging	0.16	damaging	4.30	24.00	deleterious	0.16	0.65	0.97	disease	0.84	disease	0.8	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.28	0.9	49.12	8.85	0.41	N	1.00	disease_causing	0.95	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15579	15579	A	G	MI.10110	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	833	278	Y	C	tAc/tGc	5.67	1	0	probably_damaging	1	neutral	0.17	neutral	1.73	deleterious	-7.98	deleterious	-6.21	high_impact	5.33	0.94	neutral	0.07	damaging	3.69	23.30	deleterious	0.02	0.35	0.85	disease	0.9	disease	0.86	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.15	medium_impact	3.65	high_impact	0.15	0.8	58.95	8.73	0.78	P	1.00	disease_causing_automatic	0	0.26	rs207460002	Pathogenic	Multisystem_disorder	24722	MedGen:C0559758	.	.	.	.	A15579G	Multisystem Disorder, EXIT	-	+	Cfrm	4	P	P	P	damaging
chrM	15581	15581	A	T	MI.10111	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	835	279	T	S	Aca/Tca	-0.52	0.38	0	benign	0.17	neutral	0.39	neutral	3.07	neutral	0.68	neutral	0.3	neutral_impact	0.01	0.84	neutral	0.63	neutral	3.07	22.40	deleterious	0.23	0.45	0.25	neutral	0.55	disease	0.48	neutral	0.48	neutral	0	0.53	neutral	0.61	deleterious	-6	neutral	0.20	neutral	-0.09	medium_impact	0.12	medium_impact	-1.18	low_impact	0.63	0.8	18.42	12.18	0.29	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15581	15581	A	C	MI.10112	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	835	279	T	P	Aca/Cca	-0.52	0.38	0	possibly_damaging	0.52	neutral	0.2	neutral	2.91	neutral	-2.19	neutral	-1.11	medium_impact	2.17	0.84	neutral	0.44	neutral	3.49	23.10	deleterious	0.04	0.35	0.5	neutral	0.87	disease	0.55	disease	0.74	disease	5	0.78	neutral	0.34	neutral	0	NA	0.42	neutral	-0.76	medium_impact	-0.1	medium_impact	0.78	medium_impact	0.31	0.8	18.42	12.18	0.29	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15581	15581	A	G	MI.10113	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	835	279	T	A	Aca/Gca	-0.52	0.38	0	benign	0.01	neutral	0.52	neutral	3.37	neutral	2.25	neutral	2.04	neutral_impact	-3.02	0.96	neutral	0.92	neutral	0.43	6.85	deleterious	0.17	0.45	0.26	neutral	0.07	neutral	0.19	neutral	0.25	neutral	5	0.47	neutral	0.76	deleterious	-6	neutral	0.11	neutral	1.13	medium_impact	0.24	medium_impact	-3.94	low_impact	0.24	0.8	18.42	12.18	0.37	N	0.00	polymorphism	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15582	15582	C	A	MI.10114	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	836	279	T	K	aCa/aAa	3.61	1	0	benign	0.25	neutral	0.29	neutral	2.96	neutral	-0.7	neutral	-1.09	medium_impact	2.17	0.84	neutral	0.55	neutral	4.41	24.10	deleterious	0.06	0.35	0.22	neutral	0.78	disease	0.63	disease	0.72	disease	4	0.65	neutral	0.52	deleterious	-3	neutral	0.27	neutral	-0.29	medium_impact	0.01	medium_impact	0.78	medium_impact	0.40	0.8	18.42	12.18	0.43	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15582	15582	C	T	MI.10115	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	836	279	T	M	aCa/aTa	3.61	1	0	possibly_damaging	0.85	neutral	0.21	neutral	2.91	neutral	-2.23	neutral	-1.09	medium_impact	2.17	0.85	neutral	0.51	neutral	4.10	23.70	deleterious	0.06	0.35	0.56	disease	0.67	disease	0.54	disease	0.61	disease	2	0.9	neutral	0.18	neutral	0	NA	0.53	deleterious	-1.43	low_impact	-0.09	medium_impact	0.78	medium_impact	0.49	0.8	18.42	12.18	0.44	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15584	15584	A	T	MI.10116	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	838	280	I	F	Att/Ttt	-8.31	0	0	probably_damaging	1	neutral	0.75	neutral	2.38	deleterious	-3.45	deleterious	-2.75	high_impact	4.54	0.88	neutral	0.1	damaging	3.98	23.60	deleterious	0.04	0.35	0.66	disease	0.89	disease	0.71	disease	0.74	disease	5	1	deleterious	0.38	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.48	medium_impact	2.93	high_impact	0.59	0.8	57.11	8.78	0.36	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15584	15584	A	C	MI.10117	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	838	280	I	L	Att/Ctt	-8.31	0	0	probably_damaging	0.99	neutral	0.89	neutral	2.52	neutral	-1.95	neutral	-1.38	high_impact	3.79	0.89	neutral	0.09	damaging	2.18	17.40	deleterious	0.14	0.4	0.45	neutral	0.82	disease	0.65	disease	0.69	disease	4	0.99	deleterious	0.45	neutral	2	deleterious	0.62	deleterious	-2.59	low_impact	0.71	medium_impact	2.25	high_impact	0.58	0.8	57.11	8.78	0.21	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15584	15584	A	G	MI.10118	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	838	280	I	V	Att/Gtt	-8.31	0	0	probably_damaging	0.96	neutral	0.52	neutral	2.49	neutral	-2.19	neutral	-0.69	medium_impact	3.23	0.88	neutral	0.13	damaging	1.36	12.57	neutral	0.35	0.5	0.37	neutral	0.65	disease	0.63	disease	0.66	disease	3	0.96	neutral	0.28	neutral	1	deleterious	0.68	deleterious	-2.02	low_impact	0.24	medium_impact	1.74	medium_impact	0.51	0.8	57.11	8.78	0.25	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15585	15585	T	A	MI.10119	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	839	280	I	N	aTt/aAt	5.67	1	0	probably_damaging	1	neutral	0.34	neutral	2.32	deleterious	-5.94	deleterious	-4.82	high_impact	5.24	0.87	neutral	0.1	damaging	4.67	24.50	deleterious	0.05	0.35	0.5	disease	0.93	disease	0.72	disease	0.78	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.07	medium_impact	3.56	high_impact	0.26	0.8	57.11	8.78	0.7	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9001	9001	C	T	MI.1012	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	475	159	R	C	Cgc/Tgc	-9.59	0	0	probably_damaging	1	deleterious	0	neutral	0.95	deleterious	-13.19	deleterious	-7.13	high_impact	4.63	0.52	damaging	0.11	damaging	5.10	25.30	deleterious	0.22	0.65	0.99	disease	0.89	disease	0.82	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.62	0.9	49.12	8.85	0.39	N	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15585	15585	T	G	MI.10120	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	839	280	I	S	aTt/aGt	5.67	1	0	probably_damaging	1	neutral	0.42	neutral	2.33	deleterious	-4.82	deleterious	-4.11	high_impact	4.68	0.87	neutral	0.1	damaging	4.44	24.20	deleterious	0.01	0.35	0.63	disease	0.92	disease	0.69	disease	0.73	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.15	medium_impact	3.06	high_impact	0.24	0.8	57.11	8.78	0.61	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15585	15585	T	C	MI.10121	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	839	280	I	T	aTt/aCt	5.67	1	0	probably_damaging	1	neutral	0.33	neutral	2.35	deleterious	-4.27	deleterious	-3.42	high_impact	3.99	0.87	neutral	0.09	damaging	3.55	23.10	deleterious	0.03	0.35	0.59	disease	0.86	disease	0.67	disease	0.72	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.06	medium_impact	2.43	high_impact	0.28	0.8	57.11	8.78	0.5	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15586	15586	T	A	MI.10122	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	840	280	I	M	atT/atA	5.67	1	0.01	probably_damaging	1	neutral	0.18	neutral	2.43	neutral	-2.73	neutral	-2.06	medium_impact	3.11	0.88	neutral	0.09	damaging	3.76	23.40	deleterious	0.07	0.35	0.47	neutral	0.79	disease	0.7	disease	0.71	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	-0.14	medium_impact	1.63	medium_impact	0.63	0.8	57.11	8.78	0.5	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15586	15586	T	G	MI.10123	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	840	280	I	M	atT/atG	5.67	1	0.01	probably_damaging	1	neutral	0.18	neutral	2.43	neutral	-2.73	neutral	-2.06	medium_impact	3.11	0.88	neutral	0.09	damaging	3.45	23.00	deleterious	0.07	0.35	0.47	neutral	0.79	disease	0.7	disease	0.71	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	-0.14	medium_impact	1.63	medium_impact	0.63	0.8	57.11	8.78	0.48	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15587	15587	C	T	MI.10124	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	841	281	L	F	Ctc/Ttc	-2.35	0	0	probably_damaging	0.93	neutral	0.73	neutral	1.7	deleterious	-5.16	deleterious	-2.72	high_impact	4.38	0.95	neutral	0.09	damaging	4.05	23.70	deleterious	0.14	0.4	0.57	disease	0.84	disease	0.52	disease	0.7	disease	4	0.92	neutral	0.4	neutral	2	deleterious	0.82	deleterious	-1.78	low_impact	0.46	medium_impact	2.78	high_impact	0.50	0.8	56.84	8.52	0.3	N	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15587	15587	C	A	MI.10125	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	841	281	L	I	Ctc/Atc	-2.35	0	0	possibly_damaging	0.71	neutral	0.58	neutral	1.74	deleterious	-4.5	neutral	-1.36	high_impact	4.66	0.94	neutral	0.1	damaging	4.03	23.70	deleterious	0.22	0.45	0.43	neutral	0.76	disease	0.48	neutral	0.57	disease	1	0.67	neutral	0.44	neutral	1	deleterious	0.67	deleterious	-1.09	low_impact	0.3	medium_impact	3.04	high_impact	0.57	0.8	56.84	8.52	0.38	N	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15587	15587	C	G	MI.10126	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	841	281	L	V	Ctc/Gtc	-2.35	0	0	benign	0.36	neutral	0.52	neutral	1.7	deleterious	-5.17	neutral	-2.04	high_impact	5.35	0.96	neutral	0.16	damaging	3.16	22.60	deleterious	0.18	0.45	0.63	disease	0.76	disease	0.61	disease	0.65	disease	3	0.4	neutral	0.58	deleterious	-2	neutral	0.54	deleterious	-0.5	medium_impact	0.24	medium_impact	3.66	high_impact	0.37	0.8	56.84	8.52	0.55	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15588	15588	T	C	MI.10127	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	842	281	L	P	cTc/cCc	0.17	0.02	0	benign	0.08	neutral	0.24	neutral	1.63	deleterious	-8.36	deleterious	-4.81	high_impact	4.66	0.92	neutral	0.09	damaging	3.97	23.60	deleterious	0.02	0.35	0.93	disease	0.87	disease	0.73	disease	0.76	disease	5	0.73	neutral	0.58	deleterious	-2	neutral	0.43	neutral	0.26	medium_impact	-0.05	medium_impact	3.04	high_impact	0.25	0.8	56.84	8.52	0.51	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15588	15588	T	G	MI.10128	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	842	281	L	R	cTc/cGc	0.17	0.02	0	probably_damaging	0.93	neutral	0.41	neutral	1.63	deleterious	-8.44	deleterious	-4.11	high_impact	5.35	0.94	neutral	0.06	damaging	4.19	23.90	deleterious	0.02	0.35	0.9	disease	0.92	disease	0.72	disease	0.75	disease	5	0.93	neutral	0.24	neutral	2	deleterious	0.90	deleterious	-1.78	low_impact	0.14	medium_impact	3.66	high_impact	0.19	0.8	56.84	8.52	0.63	P	0.99	polymorphism	1	0.23	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15588	15588	T	A	MI.10129	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	842	281	L	H	cTc/cAc	0.17	0.02	0	probably_damaging	0.96	neutral	0.53	neutral	1.63	deleterious	-9.06	deleterious	-4.79	high_impact	5.35	0.93	neutral	0.08	damaging	4.15	23.80	deleterious	0.03	0.35	0.92	disease	0.87	disease	0.7	disease	0.75	disease	5	0.96	neutral	0.29	neutral	2	deleterious	0.89	deleterious	-2.02	low_impact	0.25	medium_impact	3.66	high_impact	0.26	0.8	56.84	8.52	0.62	P	0.95	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9002	9002	G	T	MI.1013	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	476	159	R	L	cGc/cTc	2.21	0.97	0	probably_damaging	0.99	deleterious	0	neutral	0.96	deleterious	-11.55	deleterious	-6.18	high_impact	4.63	0.56	damaging	0.13	damaging	4.40	24.10	deleterious	0.18	0.65	0.97	disease	0.93	disease	0.79	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.25	0.9	49.12	8.85	0.51	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15590	15590	C	T	MI.10130	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	844	282	R	W	Cga/Tga	-1.44	0	0	probably_damaging	1	neutral	0.18	neutral	2.09	deleterious	-8.11	deleterious	-5.51	high_impact	4.76	0.86	neutral	0.06	damaging	5.21	25.50	deleterious	0.07	0.35	0.67	disease	0.94	disease	0.7	disease	0.8	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.14	medium_impact	3.13	high_impact	0.77	0.85	57.89	8.53	0.58	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15590	15590	C	G	MI.10131	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	844	282	R	G	Cga/Gga	-1.44	0	0	probably_damaging	1	neutral	0.41	neutral	2.12	deleterious	-5.38	deleterious	-4.81	high_impact	5.32	0.86	neutral	0.08	damaging	3.95	23.60	deleterious	0.06	0.35	0.77	disease	0.88	disease	0.7	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.14	medium_impact	3.64	high_impact	0.19	0.8	57.89	8.53	0.66	P	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15591	15591	G	A	MI.10132	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	845	282	R	Q	cGa/cAa	4.29	1	0	probably_damaging	0.99	neutral	0.28	neutral	2.17	deleterious	-3.96	deleterious	-2.75	high_impact	4.42	0.9	neutral	0.06	damaging	3.03	22.30	deleterious	0.14	0.4	0.61	disease	0.9	disease	0.64	disease	0.7	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0	medium_impact	2.82	high_impact	0.69	0.85	57.89	8.53	0.6	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15591	15591	G	C	MI.10133	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	845	282	R	P	cGa/cCa	4.29	1	0	probably_damaging	1	neutral	0.2	neutral	2.11	deleterious	-6.13	deleterious	-4.82	high_impact	4.97	0.86	neutral	0.04	damaging	4.25	23.90	deleterious	0.04	0.35	0.82	disease	0.93	disease	0.82	disease	0.75	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	-0.1	medium_impact	3.32	high_impact	0.13	0.8	57.89	8.53	0.72	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15591	15591	G	T	MI.10134	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	845	282	R	L	cGa/cTa	4.29	1	0	probably_damaging	0.99	neutral	0.79	neutral	2.12	deleterious	-5.2	deleterious	-4.81	high_impact	4.51	0.87	neutral	0.06	damaging	2.82	21.50	deleterious	0.07	0.35	0.67	disease	0.96	disease	0.68	disease	0.78	disease	6	0.99	deleterious	0.4	neutral	2	deleterious	0.90	deleterious	-2.59	low_impact	0.53	medium_impact	2.9	high_impact	0.04	0.8	57.89	8.53	0.48	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15593	15593	T	A	MI.10135	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	847	283	S	T	Tcc/Acc	-3.04	0	0	probably_damaging	0.96	neutral	0.4	neutral	2.69	neutral	-2.09	neutral	-2.05	high_impact	3.52	0.83	neutral	0.42	neutral	2.09	16.81	deleterious	0.2	0.45	0.37	neutral	0.79	disease	0.47	neutral	0.62	disease	2	0.96	neutral	0.22	neutral	2	deleterious	0.78	deleterious	-2.02	low_impact	0.13	medium_impact	2	high_impact	0.49	0.8	58.42	8.63	0.28	N	0.70	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15593	15593	T	C	MI.10136	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	847	283	S	P	Tcc/Ccc	-3.04	0	0	probably_damaging	1	neutral	0.21	neutral	2.6	deleterious	-4.26	deleterious	-3.45	high_impact	4.21	0.78	neutral	0.33	neutral	3.72	23.30	deleterious	0.05	0.35	0.82	disease	0.9	disease	0.73	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.09	medium_impact	2.63	high_impact	0.13	0.8	58.42	8.63	0.49	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15593	15593	T	G	MI.10137	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	847	283	S	A	Tcc/Gcc	-3.04	0	0	probably_damaging	0.98	neutral	0.52	neutral	2.89	neutral	-0.47	neutral	-2.04	medium_impact	2.21	0.85	neutral	0.49	neutral	2.07	16.66	deleterious	0.23	0.45	0.4	neutral	0.74	disease	0.32	neutral	0.48	neutral	0	0.98	neutral	0.27	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	0.24	medium_impact	0.81	medium_impact	0.27	0.8	58.42	8.63	0.23	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15594	15594	C	A	MI.10138	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	848	283	S	Y	tCc/tAc	4.52	1	0	probably_damaging	1	neutral	1	neutral	2.6	deleterious	-4.55	deleterious	-4.12	high_impact	4.55	0.91	neutral	0.42	neutral	4.19	23.90	deleterious	0.05	0.35	0.89	disease	0.93	disease	0.63	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.90	deleterious	-3.53	low_impact	1.85	high_impact	2.94	high_impact	0.17	0.8	58.42	8.63	0.49	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15594	15594	C	G	MI.10139	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	848	283	S	C	tCc/tGc	4.52	1	0	probably_damaging	1	neutral	0.18	neutral	2.64	deleterious	-3.02	deleterious	-3.45	high_impact	3.66	0.84	neutral	0.36	neutral	3.57	23.20	deleterious	0.06	0.35	0.87	disease	0.88	disease	0.59	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.14	medium_impact	2.13	high_impact	0.27	0.8	58.42	8.63	0.48	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9002	9002	G	C	MI.1014	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	476	159	R	P	cGc/cCc	2.21	0.97	0	probably_damaging	1	deleterious	0	neutral	0.96	deleterious	-11.93	deleterious	-6.25	high_impact	4.63	0.44	damaging	0.14	damaging	4.34	24.00	deleterious	0.13	0.65	0.98	disease	0.91	disease	0.87	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.26	0.9	49.12	8.85	0.58	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15594	15594	C	T	MI.10140	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	848	283	S	F	tCc/tTc	4.52	1	0	probably_damaging	1	neutral	0.7	neutral	2.6	deleterious	-4.24	deleterious	-4.12	high_impact	5.1	0.85	neutral	0.42	neutral	4.19	23.80	deleterious	0.05	0.35	0.87	disease	0.93	disease	0.63	disease	0.73	disease	5	1	deleterious	0.35	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.42	medium_impact	3.44	high_impact	0.08	0.8	58.42	8.63	0.69	P	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15596	15596	G	T	MI.10141	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	850	284	V	F	Gtc/Ttc	-20	0	0	possibly_damaging	0.83	neutral	0.7	neutral	2.59	deleterious	-3.62	neutral	-2.2	low_impact	1.25	0.91	neutral	0.61	neutral	3.83	23.40	deleterious	0.04	0.35	0.71	disease	0.88	disease	0.48	neutral	0.74	disease	5	0.8	neutral	0.44	neutral	-3	neutral	0.78	deleterious	-1.37	low_impact	0.42	medium_impact	-0.06	medium_impact	0.43	0.8	21.32	38.15	0.23	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15596	15596	G	A	MI.10142	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	850	284	V	I	Gtc/Atc	-20	0	0	benign	0.05	neutral	0.67	neutral	3.21	neutral	0.68	neutral	0.52	neutral_impact	-2.01	0.89	neutral	0.91	neutral	-0.66	0.09	neutral	0.32	0.5	0.25	neutral	0.05	neutral	0.18	neutral	0.24	neutral	5	0.26	neutral	0.81	deleterious	-6	neutral	0.11	neutral	0.46	medium_impact	0.39	medium_impact	-3.02	low_impact	0.86	0.9	21.32	38.15	0.51	N	0.01	polymorphism	1	0.00	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15596	15596	G	C	MI.10143	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	850	284	V	L	Gtc/Ctc	-20	0	0	benign	0.28	neutral	0.8	neutral	2.69	neutral	-1.78	neutral	-0.84	low_impact	1.84	0.92	neutral	0.57	neutral	2.07	16.65	deleterious	0.14	0.4	0.34	neutral	0.65	disease	0.44	neutral	0.48	neutral	0	0.17	neutral	0.76	deleterious	-6	neutral	0.32	neutral	-0.35	medium_impact	0.55	medium_impact	0.48	medium_impact	0.55	0.8	21.32	38.15	0.24	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15597	15597	T	A	MI.10144	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	851	284	V	D	gTc/gAc	2.69	0.98	0	probably_damaging	0.95	neutral	0.23	neutral	2.56	deleterious	-5.96	deleterious	-4.17	medium_impact	3.13	0.86	neutral	0.49	neutral	4.48	24.20	deleterious	0.02	0.35	0.92	disease	0.89	disease	0.72	disease	0.77	disease	5	0.96	neutral	0.14	neutral	1	deleterious	0.89	deleterious	-1.92	low_impact	-0.06	medium_impact	1.65	medium_impact	0.31	0.8	21.32	38.15	0.47	N	0.49	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15597	15597	T	C	MI.10145	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	851	284	V	A	gTc/gCc	2.69	0.98	0	possibly_damaging	0.52	neutral	0.63	neutral	2.61	deleterious	-3.05	deleterious	-2.71	medium_impact	2.58	0.92	neutral	0.7	neutral	2.12	16.99	deleterious	0.09	0.4	0.63	disease	0.54	disease	0.6	disease	0.66	disease	3	0.45	neutral	0.56	deleterious	0	NA	0.58	deleterious	-0.76	medium_impact	0.35	medium_impact	1.15	medium_impact	0.38	0.8	21.32	38.15	0.41	N	0.34	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15597	15597	T	G	MI.10146	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	851	284	V	G	gTc/gGc	2.69	0.98	0	possibly_damaging	0.89	neutral	0.41	neutral	2.56	deleterious	-5.22	deleterious	-4.77	medium_impact	3.13	0.91	neutral	0.5	neutral	3.72	23.30	deleterious	0.02	0.35	0.88	disease	0.77	disease	0.61	disease	0.77	disease	5	0.89	neutral	0.26	neutral	0	NA	0.83	deleterious	-1.58	low_impact	0.14	medium_impact	1.65	medium_impact	0.26	0.8	21.32	38.15	0.53	N	0.53	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15599	15599	C	G	MI.10147	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	853	285	P	A	Cct/Gct	-4.64	0	0	benign	0.06	neutral	0.89	neutral	2.55	deleterious	-3.57	deleterious	-5.42	high_impact	4.47	0.87	neutral	0.11	damaging	1.51	13.37	neutral	0.19	0.45	0.66	disease	0.81	disease	0.71	disease	0.71	disease	4	0.03	neutral	0.92	deleterious	-2	neutral	0.36	neutral	0.38	medium_impact	0.71	medium_impact	2.87	high_impact	0.60	0.8	57.89	8.7	0.3	N	0.84	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15599	15599	C	T	MI.10148	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	853	285	P	S	Cct/Tct	-4.64	0	0	possibly_damaging	0.56	neutral	0.81	neutral	2.56	deleterious	-3.41	deleterious	-5.42	high_impact	4.24	0.84	neutral	0.07	damaging	3.79	23.40	deleterious	0.16	0.45	0.43	neutral	0.91	disease	0.64	disease	0.71	disease	4	0.48	neutral	0.63	deleterious	1	deleterious	0.63	deleterious	-0.83	medium_impact	0.56	medium_impact	2.66	high_impact	0.19	0.8	57.89	8.7	0.26	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15599	15599	C	A	MI.10149	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	853	285	P	T	Cct/Act	-4.64	0	0	benign	0.35	neutral	0.59	neutral	2.55	deleterious	-3.61	deleterious	-5.42	medium_impact	3.23	0.82	neutral	0.08	damaging	3.56	23.10	deleterious	0.17	0.45	0.76	disease	0.88	disease	0.69	disease	0.71	disease	4	0.34	neutral	0.62	deleterious	-3	neutral	0.52	deleterious	-0.48	medium_impact	0.31	medium_impact	1.74	medium_impact	0.49	0.8	57.89	8.7	0.2	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9002	9002	G	A	MI.1015	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	476	159	R	H	cGc/cAc	2.21	0.97	0	probably_damaging	1	deleterious	0	neutral	0.96	deleterious	-11.9	deleterious	-4.42	high_impact	4.63	0.54	damaging	0.11	damaging	4.61	24.40	deleterious	0.26	0.65	0.97	disease	0.86	disease	0.82	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.64	0.9	49.12	8.85	0.52	P	1.00	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15600	15600	C	T	MI.10150	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	854	285	P	L	cCt/cTt	7.04	1	0	benign	0.02	neutral	0.59	neutral	2.52	deleterious	-4.29	deleterious	-6.79	high_impact	4.58	0.82	neutral	0.06	damaging	4.37	24.10	deleterious	0.09	0.35	0.9	disease	0.93	disease	0.69	disease	0.67	disease	3	0.38	neutral	0.79	deleterious	-2	neutral	0.37	neutral	0.85	medium_impact	0.31	medium_impact	2.97	high_impact	0.53	0.8	57.89	8.7	0.52	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15600	15600	C	A	MI.10151	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	854	285	P	H	cCt/cAt	7.04	1	0	probably_damaging	0.91	neutral	0.14	neutral	2.5	deleterious	-5.06	deleterious	-6.12	high_impact	5.28	0.84	neutral	0.07	damaging	4.02	23.60	deleterious	0.1	0.4	0.94	disease	0.92	disease	0.71	disease	0.65	disease	3	0.96	neutral	0.12	neutral	2	deleterious	0.87	deleterious	-1.67	low_impact	-0.21	medium_impact	3.6	high_impact	0.28	0.8	57.89	8.7	0.64	P	0.71	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15600	15600	C	G	MI.10152	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	854	285	P	R	cCt/cGt	7.04	1	0	possibly_damaging	0.88	neutral	0.55	neutral	2.52	deleterious	-4.22	deleterious	-6.12	high_impact	5.28	0.82	neutral	0.05	damaging	3.66	23.20	deleterious	0.08	0.35	0.9	disease	0.94	disease	0.77	disease	0.69	disease	4	0.86	neutral	0.34	neutral	1	deleterious	0.86	deleterious	-1.54	low_impact	0.27	medium_impact	3.6	high_impact	0.25	0.8	57.89	8.7	0.72	P	0.80	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15602	15602	A	G	MI.10153	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	856	286	N	D	Aac/Gac	-9.92	0	0	probably_damaging	0.97	neutral	0.23	neutral	2.92	neutral	-1.54	deleterious	-3.37	medium_impact	3.08	0.92	neutral	0.34	neutral	2.21	17.56	deleterious	0.43	0.55	0.37	neutral	0.83	disease	0.61	disease	0.63	disease	3	0.98	neutral	0.13	neutral	1	deleterious	0.76	deleterious	-2.14	low_impact	-0.06	medium_impact	1.6	medium_impact	0.28	0.8	57.11	8.52	0.39	N	0.96	polymorphism	1	0.04	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15602	15602	A	C	MI.10154	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	856	286	N	H	Aac/Cac	-9.92	0	0	probably_damaging	1	neutral	0.55	neutral	2.82	deleterious	-3.34	deleterious	-3.38	high_impact	4	0.94	neutral	0.19	damaging	2.91	21.90	deleterious	0.31	0.45	0.74	disease	0.86	disease	0.63	disease	0.7	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.27	medium_impact	2.44	high_impact	0.12	0.8	57.11	8.52	0.27	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15602	15602	A	T	MI.10155	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	856	286	N	Y	Aac/Tac	-9.92	0	0	probably_damaging	1	neutral	1	neutral	2.81	deleterious	-3.75	deleterious	-5.41	high_impact	5.09	0.94	neutral	0.32	neutral	3.73	23.30	deleterious	0.07	0.35	0.83	disease	0.91	disease	0.68	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.53	low_impact	1.85	high_impact	3.43	high_impact	0.11	0.8	57.11	8.52	0.61	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15603	15603	A	C	MI.10156	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	857	286	N	T	aAc/aCc	6.81	1	0	probably_damaging	0.98	neutral	0.41	neutral	2.86	neutral	-2.39	deleterious	-4.03	high_impact	3.94	0.95	neutral	0.4	neutral	1.81	15.02	deleterious	0.26	0.45	0.61	disease	0.84	disease	0.64	disease	0.7	disease	4	0.98	deleterious	0.22	neutral	2	deleterious	0.83	deleterious	-2.31	low_impact	0.14	medium_impact	2.38	high_impact	0.18	0.8	57.11	8.52	0.57	P	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15603	15603	A	G	MI.10157	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	857	286	N	S	aAc/aGc	6.81	1	0	probably_damaging	0.92	neutral	0.45	neutral	2.95	neutral	-1.27	deleterious	-3.35	low_impact	1.94	0.95	neutral	0.41	neutral	1.32	12.35	neutral	0.47	0.55	0.37	neutral	0.84	disease	0.57	disease	0.63	disease	3	0.92	neutral	0.27	neutral	-2	neutral	0.77	deleterious	-1.72	low_impact	0.18	medium_impact	0.57	medium_impact	0.13	0.8	57.11	8.52	0.49	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15603	15603	A	T	MI.10158	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	857	286	N	I	aAc/aTc	6.81	1	0	probably_damaging	1	neutral	0.44	neutral	2.79	deleterious	-4.84	deleterious	-6.08	high_impact	4.05	0.95	neutral	0.41	neutral	3.84	23.40	deleterious	0.07	0.35	0.81	disease	0.91	disease	0.66	disease	0.73	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.17	medium_impact	2.48	high_impact	0.12	0.8	57.11	8.52	0.59	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15604	15604	C	A	MI.10159	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	858	286	N	K	aaC/aaA	6.81	1	0	probably_damaging	0.99	neutral	0.35	neutral	2.86	neutral	-2.45	deleterious	-4.05	high_impact	4.29	0.95	neutral	0.27	damaging	4.16	23.80	deleterious	0.29	0.45	0.31	neutral	0.9	disease	0.62	disease	0.71	disease	4	0.99	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.08	medium_impact	2.7	high_impact	0.35	0.8	57.11	8.52	0.55	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9004	9004	C	A	MI.1016	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	478	160	L	M	Cta/Ata	-3.34	0	0.01	possibly_damaging	0.55	deleterious	0.03	neutral	1.94	deleterious	-7.62	neutral	-1.8	high_impact	3.56	0.51	damaging	0.62	neutral	3.44	23.00	deleterious	0.25	0.65	0.95	disease	0.67	disease	0.56	disease	0.79	disease	6	0.97	neutral	0.24	neutral	5	deleterious	0.63	deleterious	-0.84	medium_impact	-0.56	medium_impact	1.95	medium_impact	0.63	0.9	50	8.83	0.38	N	0.96	disease_causing	0.9	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15604	15604	C	G	MI.10160	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	858	286	N	K	aaC/aaG	6.81	1	0	probably_damaging	0.99	neutral	0.35	neutral	2.86	neutral	-2.45	deleterious	-4.05	high_impact	4.29	0.95	neutral	0.27	damaging	3.68	23.30	deleterious	0.29	0.45	0.31	neutral	0.9	disease	0.62	disease	0.71	disease	4	0.99	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.08	medium_impact	2.7	high_impact	0.35	0.8	57.11	8.52	0.54	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15605	15605	A	C	MI.10161	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	859	287	K	Q	Aaa/Caa	-7.17	0	0	probably_damaging	0.98	neutral	0.29	neutral	2.19	deleterious	-3.71	deleterious	-2.71	high_impact	4.04	0.95	neutral	0.14	damaging	1.54	13.51	neutral	0.2	0.45	0.68	disease	0.84	disease	0.76	disease	0.74	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	0.01	medium_impact	2.48	high_impact	0.28	0.8	58.16	8.7	0.42	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15605	15605	A	G	MI.10162	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	859	287	K	E	Aaa/Gaa	-7.17	0	0	probably_damaging	0.98	neutral	0.28	neutral	2.19	deleterious	-3.79	deleterious	-2.71	high_impact	3.83	0.8	neutral	0.13	damaging	2.15	17.17	deleterious	0.16	0.45	0.65	disease	0.89	disease	0.8	disease	0.76	disease	5	0.99	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-2.31	low_impact	0	medium_impact	2.28	high_impact	0.31	0.8	58.16	8.7	0.39	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15606	15606	A	C	MI.10163	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	860	287	K	T	aAa/aCa	8.42	1	0	probably_damaging	1	neutral	0.39	neutral	2.15	deleterious	-4.73	deleterious	-4.05	high_impact	4.63	0.91	neutral	0.14	damaging	3.48	23.10	deleterious	0.07	0.35	0.72	disease	0.83	disease	0.76	disease	0.74	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.12	medium_impact	3.01	high_impact	0.11	0.8	58.16	8.7	0.66	P	0.88	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15606	15606	A	T	MI.10164	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	860	287	K	M	aAa/aTa	8.42	1	0	probably_damaging	1	neutral	0.22	neutral	2.12	deleterious	-6.39	deleterious	-4.08	high_impact	4.63	0.91	neutral	0.15	damaging	3.96	23.60	deleterious	0.08	0.35	0.88	disease	0.87	disease	0.77	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.08	medium_impact	3.01	high_impact	0.19	0.8	58.16	8.7	0.68	P	0.67	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15607	15607	A	T	MI.10165	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	861	287	K	N	aaA/aaT	8.42	1	0.11	probably_damaging	1	neutral	0.32	neutral	2.16	deleterious	-4.44	deleterious	-3.38	high_impact	5.33	0.88	neutral	0.13	damaging	3.71	23.30	deleterious	0.3	0.45	0.73	disease	0.84	disease	0.75	disease	0.73	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.05	medium_impact	3.65	high_impact	0.20	0.8	58.16	8.7	0.78	P	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15607	15607	A	C	MI.10166	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	861	287	K	N	aaA/aaC	8.42	1	0.11	probably_damaging	1	neutral	0.32	neutral	2.16	deleterious	-4.44	deleterious	-3.38	high_impact	5.33	0.88	neutral	0.13	damaging	3.65	23.20	deleterious	0.3	0.45	0.73	disease	0.84	disease	0.75	disease	0.73	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.05	medium_impact	3.65	high_impact	0.20	0.8	58.16	8.7	0.78	P	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15608	15608	C	G	MI.10167	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	862	288	L	V	Cta/Gta	4.52	1	0	probably_damaging	0.98	neutral	0.33	neutral	2.8	neutral	-1.39	neutral	-1.97	high_impact	3.73	0.96	neutral	0.11	damaging	1.83	15.15	deleterious	0.2	0.45	0.33	neutral	0.66	disease	0.68	disease	0.66	disease	3	0.98	neutral	0.18	neutral	2	deleterious	0.73	deleterious	-2.31	low_impact	0.06	medium_impact	2.19	high_impact	0.45	0.8	58.16	8.77	0.47	N	0.91	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15608	15608	C	A	MI.10168	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	862	288	L	M	Cta/Ata	4.52	1	0	probably_damaging	1	neutral	0.13	neutral	2.7	neutral	-2.58	neutral	-1.34	high_impact	3.86	0.94	neutral	0.1	damaging	3.90	23.50	deleterious	0.2	0.45	0.6	disease	0.66	disease	0.67	disease	0.65	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	-0.23	medium_impact	2.31	high_impact	0.52	0.8	58.16	8.77	0.49	N	0.98	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15609	15609	T	C	MI.10169	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	863	288	L	P	cTa/cCa	-0.06	0.94	0	probably_damaging	1	neutral	0.29	neutral	2.66	deleterious	-4.48	deleterious	-4.75	high_impact	5.18	0.94	neutral	0.05	damaging	4.03	23.60	deleterious	0.02	0.35	0.77	disease	0.84	disease	0.83	disease	0.76	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.01	medium_impact	3.51	high_impact	0.24	0.8	58.16	8.77	0.71	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	COSM6716227	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9004	9004	C	G	MI.1017	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	478	160	L	V	Cta/Gta	-3.34	0	0.01	benign	0.09	deleterious	0	neutral	1.95	deleterious	-7.25	deleterious	-2.69	high_impact	4.61	0.35	damaging	0.48	neutral	1.63	14.02	neutral	0.26	0.65	0.95	disease	0.68	disease	0.69	disease	0.82	disease	6	1	deleterious	0.46	neutral	2	deleterious	0.38	neutral	0.2	medium_impact	-1.4	low_impact	2.85	high_impact	0.61	0.9	50	8.83	0.56	P	0.87	disease_causing	0.92	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15609	15609	T	A	MI.10170	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	863	288	L	Q	cTa/cAa	-0.06	0.94	0	probably_damaging	1	neutral	0.59	neutral	2.68	deleterious	-3.9	deleterious	-4.08	high_impact	4.83	0.94	neutral	0.07	damaging	4.43	24.20	deleterious	0.02	0.35	0.61	disease	0.85	disease	0.74	disease	0.72	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.31	medium_impact	3.19	high_impact	0.31	0.8	58.16	8.77	0.65	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15609	15609	T	G	MI.10171	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	863	288	L	R	cTa/cGa	-0.06	0.94	0	probably_damaging	1	neutral	0.54	neutral	2.68	deleterious	-4.06	deleterious	-4.08	high_impact	5.18	0.94	neutral	0.06	damaging	4.27	23.90	deleterious	0.02	0.35	0.68	disease	0.88	disease	0.83	disease	0.78	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.26	medium_impact	3.51	high_impact	0.16	0.8	58.16	8.77	0.7	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15611	15611	G	T	MI.10172	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	865	289	G	W	Gga/Tga	-2.81	0	0	probably_damaging	1	neutral	0.19	neutral	2.87	deleterious	-3.35	deleterious	-5.47	medium_impact	3.25	0.86	neutral	0.05	damaging	4.50	24.30	deleterious	0.05	0.35	0.53	disease	0.93	disease	0.76	disease	0.73	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-3.53	low_impact	-0.12	medium_impact	1.76	medium_impact	0.06	0.8	57.63	8.73	0.31	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15611	15611	G	C	MI.10173	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	865	289	G	R	Gga/Cga	-2.81	0	0	probably_damaging	1	neutral	0.53	neutral	2.88	neutral	-2.93	deleterious	-5.46	high_impact	5.13	0.79	neutral	0.03	damaging	3.98	23.60	deleterious	0.05	0.35	0.49	neutral	0.91	disease	0.78	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.25	medium_impact	3.46	high_impact	0.56	0.8	57.63	8.73	0.62	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15612	15612	G	C	MI.10174	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	866	289	G	A	gGa/gCa	7.27	1	0	probably_damaging	1	neutral	0.78	neutral	2.94	neutral	-1.67	deleterious	-4.08	medium_impact	3.33	0.86	neutral	0.07	damaging	3.15	22.60	deleterious	0.08	0.35	0.3	neutral	0.79	disease	0.68	disease	0.66	disease	3	1	deleterious	0.39	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.52	medium_impact	1.83	medium_impact	0.29	0.8	57.63	8.73	0.4	N	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15612	15612	G	A	MI.10175	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	866	289	G	E	gGa/gAa	7.27	1	0	probably_damaging	1	neutral	0.61	neutral	2.87	deleterious	-3.14	deleterious	-5.46	high_impact	4.78	0.72	neutral	0.04	damaging	3.98	23.60	deleterious	0.05	0.35	0.42	neutral	0.92	disease	0.76	disease	0.71	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.33	medium_impact	3.15	high_impact	0.20	0.8	57.63	8.73	0.69	P	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15612	15612	G	T	MI.10176	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	866	289	G	V	gGa/gTa	7.27	1	0	probably_damaging	1	neutral	0.62	neutral	2.93	neutral	-1.93	deleterious	-6.14	high_impact	4.24	0.81	neutral	0.06	damaging	3.86	23.50	deleterious	0.04	0.35	0.36	neutral	0.92	disease	0.7	disease	0.72	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.34	medium_impact	2.66	high_impact	0.16	0.8	57.63	8.73	0.46	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15614	15614	G	A	MI.10177	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	868	290	G	S	Ggc/Agc	-3.96	0	0	probably_damaging	1	neutral	0.41	neutral	1.42	deleterious	-5.52	deleterious	-4.12	high_impact	5.02	0.85	neutral	0.04	damaging	4.25	23.90	deleterious	0.05	0.35	0.69	disease	0.86	disease	0.73	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.14	medium_impact	3.36	high_impact	0.64	0.8	58.68	8.48	0.7	P	1.00	polymorphism	1	0.11	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15614	15614	G	C	MI.10178	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	868	290	G	R	Ggc/Cgc	-3.96	0	0	probably_damaging	1	neutral	0.35	neutral	1.36	deleterious	-8.3	deleterious	-5.5	high_impact	5.37	0.8	neutral	0.03	damaging	4.07	23.70	deleterious	0.02	0.35	0.8	disease	0.9	disease	0.84	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.08	medium_impact	3.68	high_impact	0.54	0.8	58.68	8.48	0.66	P	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15614	15614	G	T	MI.10179	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	868	290	G	C	Ggc/Tgc	-3.96	0	0	probably_damaging	1	neutral	0.18	neutral	1.35	deleterious	-8.73	deleterious	-6.19	high_impact	5.37	0.82	neutral	0.02	damaging	4.30	24.00	deleterious	0.03	0.35	0.93	disease	0.9	disease	0.76	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.14	medium_impact	3.68	high_impact	0.17	0.8	58.68	8.48	0.63	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9005	9005	T	G	MI.1018	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	479	160	L	R	cTa/cGa	-0.57	0	0	benign	0.17	deleterious	0	neutral	1.92	deleterious	-9.98	deleterious	-5.39	high_impact	4.61	0.29	damaging	0.39	neutral	2.48	19.31	deleterious	0.13	0.65	0.99	disease	0.9	disease	0.78	disease	0.89	disease	8	1	deleterious	0.42	neutral	2	deleterious	0.56	deleterious	-0.1	medium_impact	-1.4	low_impact	2.85	high_impact	0.49	0.9	50	8.83	0.79	P	0.99	polymorphism	0.6	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15615	15615	G	A	MI.10180	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	869	290	G	D	gGc/gAc	9.11	1	0	probably_damaging	1	neutral	0.2	neutral	1.37	deleterious	-7.57	deleterious	-4.81	high_impact	5.37	0.8	neutral	0.04	damaging	3.92	23.50	deleterious	0.02	0.35	0.7	disease	0.91	disease	0.84	disease	0.76	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.1	medium_impact	3.68	high_impact	0.17	0.8	58.68	8.48	0.82	P	1.00	disease_causing_automatic	0	0.23	rs207459997	Pathogenic	Exercise_intolerance	24717	MedGen:C0241885	.	.	.	.	G15615A	EXIT / Antimycin resistance	-	+	Reported	3	P	P	P	damaging
chrM	15615	15615	G	C	MI.10181	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	869	290	G	A	gGc/gCc	9.11	1	0	probably_damaging	1	neutral	0.51	neutral	1.49	deleterious	-4.61	deleterious	-4.12	high_impact	5.37	0.87	neutral	0.07	damaging	3.15	22.60	deleterious	0.05	0.35	0.68	disease	0.77	disease	0.73	disease	0.7	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.23	medium_impact	3.68	high_impact	0.42	0.8	58.68	8.48	0.74	P	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15615	15615	G	T	MI.10182	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	869	290	G	V	gGc/gTc	9.11	1	0	probably_damaging	1	neutral	0.52	neutral	1.36	deleterious	-7.97	deleterious	-6.19	high_impact	5.37	0.82	neutral	0.06	damaging	3.85	23.40	deleterious	0.02	0.35	0.81	disease	0.9	disease	0.78	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.24	medium_impact	3.68	high_impact	0.20	0.8	58.68	8.48	0.73	P	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15617	15617	G	A	MI.10183	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	871	291	V	I	Gtc/Atc	-10.6	0	0	probably_damaging	0.98	neutral	0.4	neutral	2.48	neutral	-1.94	neutral	-0.68	medium_impact	3.47	0.73	neutral	0.49	neutral	1.89	15.50	deleterious	0.43	0.55	0.49	neutral	0.68	disease	0.62	disease	0.64	disease	3	0.98	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-2.31	low_impact	0.13	medium_impact	1.96	medium_impact	0.83	0.9	57.37	8.75	0.3	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15617	15617	G	T	MI.10184	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	871	291	V	F	Gtc/Ttc	-10.6	0	0	probably_damaging	1	neutral	0.7	neutral	2.29	deleterious	-4.33	deleterious	-3.38	high_impact	3.54	0.81	neutral	0.44	neutral	3.89	23.50	deleterious	0.04	0.35	0.51	disease	0.92	disease	0.71	disease	0.72	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.42	medium_impact	2.02	high_impact	0.26	0.8	57.37	8.75	0.21	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15617	15617	G	C	MI.10185	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	871	291	V	L	Gtc/Ctc	-10.6	0	0	probably_damaging	0.98	neutral	0.65	neutral	2.49	neutral	-1.85	neutral	-2.03	medium_impact	3.15	0.82	neutral	0.43	neutral	1.88	15.46	deleterious	0.18	0.45	0.31	neutral	0.82	disease	0.66	disease	0.67	disease	3	0.98	neutral	0.34	neutral	1	deleterious	0.76	deleterious	-2.31	low_impact	0.37	medium_impact	1.67	medium_impact	0.32	0.8	57.37	8.75	0.22	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15618	15618	T	C	MI.10186	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	872	291	V	A	gTc/gCc	5.9	1	0	probably_damaging	1	neutral	0.51	neutral	2.3	deleterious	-3.96	deleterious	-2.69	high_impact	4.04	0.73	neutral	0.52	neutral	3.43	23.00	deleterious	0.08	0.35	0.6	disease	0.73	disease	0.62	disease	0.65	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.23	medium_impact	2.48	high_impact	0.16	0.8	57.37	8.75	0.62	P	0.62	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15618	15618	T	G	MI.10187	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	872	291	V	G	gTc/gGc	5.9	1	0	probably_damaging	1	neutral	0.34	neutral	2.25	deleterious	-6.12	deleterious	-4.71	high_impact	4.68	0.81	neutral	0.49	neutral	3.85	23.40	deleterious	0.03	0.35	0.81	disease	0.84	disease	0.66	disease	0.67	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.07	medium_impact	3.06	high_impact	0.18	0.8	57.37	8.75	0.63	P	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15618	15618	T	A	MI.10188	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	872	291	V	D	gTc/gAc	5.9	1	0	probably_damaging	1	neutral	0.2	neutral	2.25	deleterious	-6.86	deleterious	-4.7	high_impact	4.68	0.76	neutral	0.42	neutral	4.50	24.30	deleterious	0.02	0.35	0.89	disease	0.92	disease	0.78	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.1	medium_impact	3.06	high_impact	0.15	0.8	57.37	8.75	0.68	P	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15620	15620	C	G	MI.10189	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	874	292	L	V	Ctt/Gtt	-11.06	0	0	benign	0.09	neutral	0.73	neutral	2.97	neutral	-0.14	neutral	-1.67	low_impact	1.6	0.96	neutral	0.82	neutral	0.59	8.10	deleterious	0.24	0.45	0.25	neutral	0.52	disease	0.37	neutral	0.42	neutral	2	0.16	neutral	0.82	deleterious	-6	neutral	0.22	neutral	0.21	medium_impact	0.46	medium_impact	0.26	medium_impact	0.55	0.8	25	12.47	0.25	N	0.17	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9005	9005	T	A	MI.1019	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	479	160	L	Q	cTa/cAa	-0.57	0	0	benign	0.01	deleterious	0	neutral	1.91	deleterious	-10.14	deleterious	-5.39	high_impact	4.61	0.33	damaging	0.47	neutral	2.24	17.77	deleterious	0.16	0.65	0.99	disease	0.86	disease	0.69	disease	0.84	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.35	neutral	1.14	medium_impact	-1.4	low_impact	2.85	high_impact	0.54	0.9	50	8.83	0.58	P	0.98	polymorphism	0.65	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15620	15620	C	T	MI.10190	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	874	292	L	F	Ctt/Ttt	-11.06	0	0	possibly_damaging	0.44	neutral	0.28	neutral	2.73	neutral	-2.58	neutral	-2.49	medium_impact	3.34	0.95	neutral	0.13	damaging	3.74	23.30	deleterious	0.13	0.4	0.71	disease	0.71	disease	0.62	disease	0.64	disease	3	0.68	neutral	0.42	neutral	0	NA	0.64	deleterious	-0.63	medium_impact	0	medium_impact	1.84	medium_impact	0.42	0.8	25	12.47	0.3	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15620	15620	C	A	MI.10191	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	874	292	L	I	Ctt/Att	-11.06	0	0	benign	0.22	neutral	0.43	neutral	2.95	neutral	-0.24	neutral	-1.09	low_impact	1.48	0.96	neutral	0.72	neutral	1.51	13.35	neutral	0.22	0.45	0.28	neutral	0.46	neutral	0.29	neutral	0.42	neutral	2	0.48	neutral	0.61	deleterious	-6	neutral	0.25	neutral	-0.22	medium_impact	0.16	medium_impact	0.15	medium_impact	0.50	0.8	25	12.47	0.39	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	C15620A	Leigh Syndrome helper mut	-	+	Reported	1	.	P	P	neutral
chrM	15621	15621	T	A	MI.10192	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	875	292	L	H	cTt/cAt	-0.98	0	0	probably_damaging	0.91	neutral	0.15	neutral	2.68	deleterious	-4.45	deleterious	-4.43	high_impact	4.14	0.93	neutral	0.11	damaging	4.11	23.70	deleterious	0.03	0.35	0.89	disease	0.83	disease	0.69	disease	0.77	disease	5	0.95	neutral	0.12	neutral	2	deleterious	0.83	deleterious	-1.67	low_impact	-0.19	medium_impact	2.57	high_impact	0.26	0.8	25	12.47	0.42	N	0.86	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15621	15621	T	C	MI.10193	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	875	292	L	P	cTt/cCt	-0.98	0	0	probably_damaging	0.94	neutral	0.12	neutral	2.68	deleterious	-4.44	deleterious	-4.43	high_impact	4.14	0.94	neutral	0.08	damaging	3.92	23.50	deleterious	0.02	0.35	0.88	disease	0.86	disease	0.73	disease	0.76	disease	5	0.97	neutral	0.09	neutral	2	deleterious	0.87	deleterious	-1.85	low_impact	-0.25	medium_impact	2.57	high_impact	0.20	0.8	25	12.47	0.41	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15621	15621	T	G	MI.10194	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	875	292	L	R	cTt/cGt	-0.98	0	0	possibly_damaging	0.77	neutral	0.12	neutral	2.7	deleterious	-3.68	deleterious	-3.82	high_impact	4.84	0.94	neutral	0.08	damaging	4.12	23.80	deleterious	0.02	0.35	0.85	disease	0.89	disease	0.73	disease	0.77	disease	5	0.92	neutral	0.18	neutral	1	deleterious	0.78	deleterious	-1.22	low_impact	-0.25	medium_impact	3.2	high_impact	0.18	0.8	25	12.47	0.68	P	0.95	polymorphism	1	0.19	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15623	15623	G	C	MI.10195	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	877	293	A	P	Gcc/Ccc	-2.35	0	0	probably_damaging	1	neutral	0.11	neutral	2.78	deleterious	-3.94	deleterious	-3.38	high_impact	5.18	0.88	neutral	0.04	damaging	3.84	23.40	deleterious	0.03	0.35	0.5	disease	0.9	disease	0.74	disease	0.75	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.27	medium_impact	3.51	high_impact	0.46	0.8	57.89	8.64	0.7	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15623	15623	G	A	MI.10196	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	877	293	A	T	Gcc/Acc	-2.35	0	0	probably_damaging	1	neutral	0.17	neutral	2.82	neutral	-2.73	deleterious	-2.7	high_impact	3.73	0.92	neutral	0.12	damaging	4.17	23.80	deleterious	0.11	0.4	0.51	disease	0.82	disease	0.57	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.15	medium_impact	2.19	high_impact	0.68	0.85	57.89	8.64	0.38	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15623	15623	G	T	MI.10197	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	877	293	A	S	Gcc/Tcc	-2.35	0	0	probably_damaging	1	neutral	0.26	neutral	2.81	neutral	-2.95	neutral	-2.02	high_impact	3.68	0.87	neutral	0.09	damaging	3.61	23.20	deleterious	0.18	0.45	0.56	disease	0.85	disease	0.56	disease	0.67	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.02	medium_impact	2.15	high_impact	0.34	0.8	57.89	8.64	0.31	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15624	15624	C	G	MI.10198	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	878	293	A	G	gCc/gGc	5.9	1	0	probably_damaging	1	neutral	0.33	neutral	2.8	deleterious	-3.45	deleterious	-2.7	medium_impact	3.19	0.87	neutral	0.14	damaging	3.73	23.30	deleterious	0.16	0.45	0.71	disease	0.79	disease	0.54	disease	0.66	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.78	deleterious	-3.53	low_impact	0.06	medium_impact	1.7	medium_impact	0.70	0.85	57.89	8.64	0.5	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15624	15624	C	A	MI.10199	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	878	293	A	D	gCc/gAc	5.9	1	0	probably_damaging	1	neutral	0.08	neutral	2.77	deleterious	-4.44	deleterious	-4.05	high_impact	5.18	0.85	neutral	0.08	damaging	4.57	24.40	deleterious	0.03	0.35	0.72	disease	0.93	disease	0.73	disease	0.79	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.35	medium_impact	3.51	high_impact	0.24	0.8	57.89	8.64	0.71	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8572	8572	G	T	MI.102	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	46	16	G	C	Ggc/Tgc	0.13	0.8	0.01	probably_damaging	0.96	deleterious	0.02	neutral	4.56	neutral	-2.75	deleterious	-7.26	high_impact	3.67	0.78	neutral	0.2	damaging	3.82	23.40	deleterious	0.2	0.65	0.84	disease	0.9	disease	0.61	disease	0.76	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.83	deleterious	-2.07	low_impact	-0.66	medium_impact	2.05	high_impact	0.72	0.9	17.26	11.64	0.29	N	0.90	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9005	9005	T	C	MI.1020	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	479	160	L	P	cTa/cCa	-0.57	0	0	possibly_damaging	0.47	deleterious	0.03	neutral	1.91	deleterious	-10.36	deleterious	-6.33	high_impact	4.26	0.21	damaging	0.46	neutral	2.33	18.36	deleterious	0.15	0.65	0.99	disease	0.85	disease	0.78	disease	0.88	disease	8	0.97	neutral	0.28	neutral	5	deleterious	0.67	deleterious	-0.71	medium_impact	-0.56	medium_impact	2.55	high_impact	0.49	0.9	50	8.83	0.85	P	1.00	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15624	15624	C	T	MI.10200	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	878	293	A	V	gCc/gTc	5.9	1	0	probably_damaging	1	neutral	0.48	neutral	2.9	neutral	-1.59	deleterious	-2.7	medium_impact	3.22	0.88	neutral	0.11	damaging	4.42	24.20	deleterious	0.11	0.4	0.45	neutral	0.87	disease	0.63	disease	0.71	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.80	deleterious	-3.53	low_impact	0.2	medium_impact	1.73	medium_impact	0.68	0.85	57.89	8.64	0.5	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15626	15626	C	A	MI.10201	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	880	294	L	M	Cta/Ata	-3.5	0	0.01	probably_damaging	1	neutral	0.16	neutral	2.98	neutral	-0.06	neutral	-1.34	medium_impact	2.41	0.94	neutral	0.11	damaging	3.75	23.30	deleterious	0.17	0.45	0.33	neutral	0.66	disease	0.38	neutral	0.38	neutral	2	1	deleterious	0.08	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	-0.17	medium_impact	1	medium_impact	0.43	0.8	58.16	8.69	0.33	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15626	15626	C	G	MI.10202	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	880	294	L	V	Cta/Gta	-3.5	0	0.01	probably_damaging	0.98	neutral	0.43	neutral	2.64	neutral	-2.32	neutral	-2.02	high_impact	4	0.96	neutral	0.12	damaging	1.84	15.20	deleterious	0.2	0.45	0.39	neutral	0.67	disease	0.6	disease	0.65	disease	3	0.98	neutral	0.23	neutral	2	deleterious	0.74	deleterious	-2.31	low_impact	0.16	medium_impact	2.44	high_impact	0.48	0.8	58.16	8.69	0.32	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15627	15627	T	A	MI.10203	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	881	294	L	Q	cTa/cAa	-0.06	0	0	probably_damaging	1	neutral	0.15	neutral	2.56	deleterious	-4.27	deleterious	-4.04	high_impact	4.05	0.93	neutral	0.08	damaging	4.11	23.70	deleterious	0.04	0.35	0.8	disease	0.84	disease	0.6	disease	0.68	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.19	medium_impact	2.48	high_impact	0.22	0.8	58.16	8.69	0.39	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15627	15627	T	G	MI.10204	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	881	294	L	R	cTa/cGa	-0.06	0	0	probably_damaging	1	neutral	0.17	neutral	2.55	deleterious	-4.85	deleterious	-4.04	high_impact	4.75	0.94	neutral	0.06	damaging	4.24	23.90	deleterious	0.03	0.35	0.79	disease	0.9	disease	0.72	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.15	medium_impact	3.12	high_impact	0.18	0.8	58.16	8.69	0.69	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15627	15627	T	C	MI.10205	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	881	294	L	P	cTa/cCa	-0.06	0	0	probably_damaging	1	neutral	0.16	neutral	2.54	deleterious	-5.46	deleterious	-4.72	high_impact	4.2	0.93	neutral	0.06	damaging	3.97	23.60	deleterious	0.04	0.35	0.82	disease	0.85	disease	0.71	disease	0.71	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.17	medium_impact	2.62	high_impact	0.21	0.8	58.16	8.69	0.42	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15629	15629	T	A	MI.10206	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	883	295	L	M	Tta/Ata	-1.21	0	0	benign	0.28	neutral	0.18	neutral	2.85	neutral	-1.87	neutral	-0.83	medium_impact	2.46	0.89	neutral	0.9	neutral	2.54	19.72	deleterious	0.26	0.45	0.45	neutral	0.58	disease	0.31	neutral	0.25	neutral	5	0.79	neutral	0.45	neutral	-3	neutral	0.29	neutral	-0.35	medium_impact	-0.14	medium_impact	1.04	medium_impact	0.49	0.8	21.32	27.73	0.44	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15629	15629	T	G	MI.10207	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	883	295	L	V	Tta/Gta	-1.21	0	0	possibly_damaging	0.52	neutral	0.4	neutral	3.02	neutral	0.15	neutral	-0.86	low_impact	0.81	0.95	neutral	0.95	neutral	0.98	10.56	neutral	0.27	0.45	0.19	neutral	0.33	neutral	0.24	neutral	0.45	neutral	1	0.59	neutral	0.44	neutral	-3	neutral	0.42	neutral	-0.76	medium_impact	0.13	medium_impact	-0.46	medium_impact	0.36	0.8	21.32	27.73	0.4	N	0.03	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15630	15630	T	G	MI.10208	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	884	295	L	W	tTa/tGa	-3.73	0	0	probably_damaging	0.98	deleterious	0.03	neutral	2.8	deleterious	-4.24	deleterious	-3.23	high_impact	4.38	0.84	neutral	0.47	neutral	3.81	23.40	deleterious	0.05	0.35	0.8	disease	0.83	disease	0.58	disease	0.69	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.82	deleterious	-2.31	low_impact	-0.6	medium_impact	2.78	high_impact	0.19	0.8	21.32	27.73	0.46	N	0.45	polymorphism	1	0.19	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15630	15630	T	C	MI.10209	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	884	295	L	S	tTa/tCa	-3.73	0	0	possibly_damaging	0.86	neutral	0.25	neutral	2.85	neutral	-1.85	deleterious	-2.77	medium_impact	3.23	0.83	neutral	0.62	neutral	3.80	23.40	deleterious	0.06	0.35	0.5	neutral	0.76	disease	0.55	disease	0.65	disease	3	0.89	neutral	0.2	neutral	0	NA	0.73	deleterious	-1.47	low_impact	-0.04	medium_impact	1.74	medium_impact	0.25	0.8	21.32	27.73	0.3	N	0.15	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9007	9007	A	T	MI.1021	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	481	161	T	S	Acc/Tcc	-6.81	0	0	probably_damaging	0.99	neutral	0.1	neutral	4.27	neutral	-0.63	deleterious	-3.59	medium_impact	2.08	0.6	damaging	0.64	neutral	3.40	23.00	deleterious	0.48	0.65	0.67	disease	0.71	disease	0.52	disease	0.56	disease	1	0.99	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	-0.25	medium_impact	0.69	medium_impact	0.78	0.9	50.44	8.87	0.31	N	0.88	disease_causing	0.52	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15631	15631	A	C	MI.10210	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	885	295	L	F	ttA/ttC	1.77	0.01	0	possibly_damaging	0.75	neutral	0.36	neutral	2.96	neutral	-0.34	neutral	-1.9	low_impact	1.66	0.85	neutral	0.83	neutral	2.33	18.36	deleterious	0.18	0.45	0.43	neutral	0.68	disease	0.31	neutral	0.25	neutral	5	0.78	neutral	0.31	neutral	-3	neutral	0.69	deleterious	-1.18	low_impact	0.09	medium_impact	0.31	medium_impact	0.41	0.8	21.32	27.73	0.34	N	0.03	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15631	15631	A	T	MI.10211	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	885	295	L	F	ttA/ttT	1.77	0.01	0	possibly_damaging	0.75	neutral	0.36	neutral	2.96	neutral	-0.34	neutral	-1.9	low_impact	1.66	0.85	neutral	0.83	neutral	2.47	19.28	deleterious	0.18	0.45	0.43	neutral	0.68	disease	0.31	neutral	0.25	neutral	5	0.78	neutral	0.31	neutral	-3	neutral	0.69	deleterious	-1.18	low_impact	0.09	medium_impact	0.31	medium_impact	0.41	0.8	21.32	27.73	0.34	N	0.03	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15632	15632	C	G	MI.10212	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	886	296	L	V	Cta/Gta	-7.62	0	0.01	possibly_damaging	0.52	neutral	0.69	neutral	2.89	neutral	-0.75	neutral	-0.73	medium_impact	3.01	0.95	neutral	0.58	neutral	2.22	17.63	deleterious	0.25	0.45	0.37	neutral	0.49	neutral	0.38	neutral	0.47	neutral	1	0.43	neutral	0.59	deleterious	0	NA	0.51	deleterious	-0.76	medium_impact	0.41	medium_impact	1.54	medium_impact	0.58	0.8	13.95	18.97	0.27	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15632	15632	C	A	MI.10213	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	886	296	L	M	Cta/Ata	-7.62	0	0.01	benign	0.28	neutral	0.26	neutral	2.84	neutral	-2.29	neutral	-0.16	neutral_impact	0.7	0.96	neutral	0.87	neutral	2.34	18.45	deleterious	0.22	0.45	0.41	neutral	0.25	neutral	0.26	neutral	0.46	neutral	1	0.69	neutral	0.49	deleterious	-6	neutral	0.30	neutral	-0.35	medium_impact	-0.02	medium_impact	-0.56	medium_impact	0.44	0.8	13.95	18.97	0.42	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15633	15633	T	G	MI.10214	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	887	296	L	R	cTa/cGa	-5.79	0	0	probably_damaging	0.93	neutral	0.19	neutral	2.78	deleterious	-3.4	neutral	-2.03	high_impact	4.11	0.94	neutral	0.45	neutral	4.19	23.80	deleterious	0.03	0.35	0.62	disease	0.86	disease	0.55	disease	0.67	disease	3	0.96	neutral	0.13	neutral	2	deleterious	0.82	deleterious	-1.78	low_impact	-0.12	medium_impact	2.54	high_impact	0.22	0.8	13.95	18.97	0.45	N	0.90	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15633	15633	T	A	MI.10215	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	887	296	L	Q	cTa/cAa	-5.79	0	0	probably_damaging	0.93	neutral	0.16	neutral	2.78	deleterious	-3.54	neutral	-1.93	high_impact	4.11	0.94	neutral	0.5	neutral	4.27	24.00	deleterious	0.04	0.35	0.62	disease	0.63	disease	0.41	neutral	0.44	neutral	1	0.96	neutral	0.12	neutral	2	deleterious	0.75	deleterious	-1.78	low_impact	-0.17	medium_impact	2.54	high_impact	0.24	0.8	13.95	18.97	0.48	N	0.82	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15633	15633	T	C	MI.10216	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	887	296	L	P	cTa/cCa	-5.79	0	0	probably_damaging	0.96	neutral	0.25	neutral	2.77	deleterious	-3.68	deleterious	-2.52	medium_impact	3.31	0.93	neutral	0.34	neutral	4.01	23.60	deleterious	0.03	0.35	0.56	disease	0.87	disease	0.55	disease	0.68	disease	4	0.97	neutral	0.15	neutral	1	deleterious	0.82	deleterious	-2.02	low_impact	-0.04	medium_impact	1.81	medium_impact	0.16	0.8	13.95	18.97	0.37	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15635	15635	T	C	MI.10217	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	889	297	S	P	Tcc/Ccc	-4.64	0	0	probably_damaging	1	neutral	0.26	neutral	2.66	deleterious	-4.03	deleterious	-3.32	high_impact	5.18	0.93	neutral	0.33	neutral	3.80	23.40	deleterious	0.04	0.35	0.76	disease	0.87	disease	0.75	disease	0.69	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.02	medium_impact	3.51	high_impact	0.25	0.8	57.63	8.46	0.77	P	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	T15635C	Polyvisceral failure	+	-	Reported	1	.	P	P	damaging
chrM	15635	15635	T	A	MI.10218	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	889	297	S	T	Tcc/Acc	-4.64	0	0	probably_damaging	0.98	neutral	0.32	neutral	2.72	neutral	-2.23	neutral	-1.98	high_impact	4.08	0.95	neutral	0.42	neutral	2.10	16.86	deleterious	0.23	0.45	0.51	disease	0.67	disease	0.64	disease	0.65	disease	3	0.98	deleterious	0.17	neutral	2	deleterious	0.77	deleterious	-2.31	low_impact	0.05	medium_impact	2.51	high_impact	0.50	0.8	57.63	8.46	0.4	N	0.70	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15635	15635	T	G	MI.10219	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	889	297	S	A	Tcc/Gcc	-4.64	0	0	probably_damaging	0.99	neutral	0.7	neutral	2.92	neutral	-0.38	neutral	-1.96	medium_impact	2.38	0.96	neutral	0.49	neutral	2.09	16.79	deleterious	0.24	0.45	0.24	neutral	0.61	disease	0.47	neutral	0.17	neutral	7	0.99	deleterious	0.36	neutral	1	deleterious	0.71	deleterious	-2.59	low_impact	0.42	medium_impact	0.97	medium_impact	0.37	0.8	57.63	8.46	0.24	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9007	9007	A	G	MI.1022	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	481	161	T	A	Acc/Gcc	-6.81	0	0	probably_damaging	0.99	neutral	0.47	neutral	4.32	neutral	0.4	deleterious	-4.49	low_impact	1.17	0.73	neutral	0.61	neutral	3.58	23.20	deleterious	0.58	0.7	0.38	neutral	0.39	neutral	0.38	neutral	0.4	neutral	2	0.99	deleterious	0.24	neutral	-2	neutral	0.69	deleterious	-2.65	low_impact	0.26	medium_impact	-0.1	medium_impact	0.44	0.9	50.44	8.87	0.32	N	0.63	disease_causing	0.77	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15636	15636	C	T	MI.10220	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	890	297	S	F	tCc/tTc	5.44	1	0	probably_damaging	1	neutral	0.73	neutral	2.67	deleterious	-3.79	deleterious	-3.98	high_impact	4.21	0.95	neutral	0.51	neutral	4.21	23.90	deleterious	0.05	0.35	0.61	disease	0.9	disease	0.61	disease	0.67	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.46	medium_impact	2.63	high_impact	0.08	0.8	57.63	8.46	0.49	N	1.00	polymorphism	1	0.05	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15636	15636	C	G	MI.10221	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	890	297	S	C	tCc/tGc	5.44	1	0	probably_damaging	1	neutral	0.12	neutral	2.65	deleterious	-4.67	deleterious	-3.31	high_impact	4.84	0.95	neutral	0.36	neutral	3.58	23.20	deleterious	0.08	0.35	0.76	disease	0.79	disease	0.61	disease	0.66	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.25	medium_impact	3.2	high_impact	0.23	0.8	57.63	8.46	0.71	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15636	15636	C	A	MI.10222	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	890	297	S	Y	tCc/tAc	5.44	1	0	probably_damaging	1	neutral	0.81	neutral	2.66	deleterious	-4.06	deleterious	-3.98	high_impact	4.63	0.95	neutral	0.39	neutral	4.22	23.90	deleterious	0.06	0.35	0.68	disease	0.88	disease	0.65	disease	0.67	disease	3	1	deleterious	0.41	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.56	medium_impact	3.01	high_impact	0.20	0.8	57.63	8.46	0.55	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15638	15638	A	T	MI.10223	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	892	298	I	F	Atc/Ttc	-20	0	0	probably_damaging	1	neutral	0.69	neutral	2.53	deleterious	-3.1	deleterious	-2.66	high_impact	3.67	0.77	neutral	0.37	neutral	3.78	23.40	deleterious	0.11	0.4	0.41	neutral	0.8	disease	0.61	disease	0.65	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.41	medium_impact	2.14	high_impact	0.48	0.8	56.05	8.69	0.23	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15638	15638	A	C	MI.10224	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	892	298	I	L	Atc/Ctc	-20	0	0	probably_damaging	0.99	neutral	1	neutral	2.77	neutral	-0.91	neutral	-1.32	medium_impact	2.73	0.84	neutral	0.35	neutral	2.18	17.38	deleterious	0.26	0.45	0.31	neutral	0.73	disease	0.43	neutral	0.47	neutral	1	0.99	deleterious	0.51	deleterious	1	deleterious	0.68	deleterious	-2.59	low_impact	1.85	high_impact	1.29	medium_impact	0.50	0.8	56.05	8.69	0.17	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15638	15638	A	G	MI.10225	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	892	298	I	V	Atc/Gtc	-20	0	0	probably_damaging	0.96	neutral	0.54	neutral	2.71	neutral	-1.25	neutral	-0.54	low_impact	1.63	0.92	neutral	0.46	neutral	1.28	12.16	neutral	0.44	0.55	0.35	neutral	0.37	neutral	0.45	neutral	0.4	neutral	2	0.96	neutral	0.29	neutral	-2	neutral	0.65	deleterious	-2.02	low_impact	0.26	medium_impact	0.29	medium_impact	0.49	0.8	56.05	8.69	0.31	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15639	15639	T	A	MI.10226	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	893	298	I	N	aTc/aAc	5.44	1	0	probably_damaging	1	neutral	0.19	neutral	2.47	deleterious	-5.35	deleterious	-4.59	high_impact	4.05	0.86	neutral	0.39	neutral	4.50	24.30	deleterious	0.08	0.35	0.76	disease	0.81	disease	0.66	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.12	medium_impact	2.48	high_impact	0.34	0.8	56.05	8.69	0.57	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15639	15639	T	C	MI.10227	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	893	298	I	T	aTc/aCc	5.44	1	0	probably_damaging	1	neutral	0.26	neutral	2.51	deleterious	-3.68	deleterious	-3.19	high_impact	4.54	0.86	neutral	0.41	neutral	3.39	23.00	deleterious	0.08	0.35	0.56	disease	0.68	disease	0.64	disease	0.65	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	-0.02	medium_impact	2.93	high_impact	0.26	0.8	56.05	8.69	0.59	P	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15639	15639	T	G	MI.10228	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	893	298	I	S	aTc/aGc	5.44	1	0	probably_damaging	1	neutral	0.83	neutral	2.49	deleterious	-4.22	deleterious	-3.92	high_impact	4.54	0.84	neutral	0.39	neutral	4.32	24.00	deleterious	0.04	0.35	0.61	disease	0.83	disease	0.63	disease	0.67	disease	3	1	deleterious	0.42	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.6	medium_impact	2.93	high_impact	0.25	0.8	56.05	8.69	0.51	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15640	15640	C	A	MI.10229	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	894	298	I	M	atC/atA	5.67	1	0	probably_damaging	1	neutral	0.33	neutral	2.51	deleterious	-3.6	neutral	-1.92	high_impact	4.05	0.84	neutral	0.36	neutral	3.86	23.50	deleterious	0.16	0.45	0.61	disease	0.71	disease	0.59	disease	0.64	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.06	medium_impact	2.48	high_impact	0.46	0.8	56.05	8.69	0.56	P	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9007	9007	A	C	MI.1023	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	481	161	T	P	Acc/Ccc	-6.81	0	0	probably_damaging	1	deleterious	0.01	neutral	4.21	neutral	-2.78	deleterious	-5.47	high_impact	3.93	0.52	damaging	0.48	neutral	3.57	23.20	deleterious	0.18	0.65	0.84	disease	0.88	disease	0.74	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-0.84	medium_impact	2.27	high_impact	0.54	0.9	50.44	8.87	0.36	N	0.99	disease_causing	0.94	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15640	15640	C	G	MI.10230	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	894	298	I	M	atC/atG	5.67	1	0	probably_damaging	1	neutral	0.33	neutral	2.51	deleterious	-3.6	neutral	-1.92	high_impact	4.05	0.84	neutral	0.36	neutral	3.38	22.90	deleterious	0.16	0.45	0.61	disease	0.71	disease	0.59	disease	0.64	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.06	medium_impact	2.48	high_impact	0.46	0.8	56.05	8.69	0.55	P	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15641	15641	C	G	MI.10231	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	895	299	L	V	Ctc/Gtc	-2.58	0	0	probably_damaging	0.98	neutral	0.53	neutral	2.86	neutral	-0.28	neutral	-1.61	low_impact	1.85	0.97	neutral	0.65	neutral	1.84	15.20	deleterious	0.32	0.5	0.31	neutral	0.61	disease	0.36	neutral	0.37	neutral	3	0.97	neutral	0.28	neutral	-2	neutral	0.72	deleterious	-2.31	low_impact	0.25	medium_impact	0.49	medium_impact	0.49	0.8	41.05	8.01	0.24	N	0.91	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15641	15641	C	A	MI.10232	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	895	299	L	I	Ctc/Atc	-2.58	0	0	probably_damaging	0.99	neutral	0.98	neutral	2.81	neutral	-0.79	neutral	-1.11	medium_impact	2.52	0.94	neutral	0.49	neutral	3.84	23.40	deleterious	0.32	0.5	0.34	neutral	0.66	disease	0.47	neutral	0.37	neutral	3	0.99	deleterious	0.5	deleterious	1	deleterious	0.73	deleterious	-2.59	low_impact	1.14	medium_impact	1.1	medium_impact	0.39	0.8	41.05	8.01	0.21	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15641	15641	C	T	MI.10233	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	895	299	L	F	Ctc/Ttc	-2.58	0	0	probably_damaging	1	neutral	0.59	neutral	2.78	neutral	-2.69	neutral	-2.29	medium_impact	2.52	0.96	neutral	0.52	neutral	3.91	23.50	deleterious	0.21	0.45	0.57	disease	0.65	disease	0.4	neutral	0.23	neutral	5	1	deleterious	0.3	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.31	medium_impact	1.1	medium_impact	0.35	0.8	41.05	8.01	0.2	N	0.97	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15642	15642	T	A	MI.10234	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	896	299	L	H	cTc/cAc	-0.06	0	0	probably_damaging	1	neutral	0.12	neutral	2.7	deleterious	-4.21	deleterious	-4.08	high_impact	4.82	0.93	neutral	0.42	neutral	4.19	23.80	deleterious	0.05	0.35	0.76	disease	0.81	disease	0.67	disease	0.68	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.25	medium_impact	3.18	high_impact	0.16	0.8	41.05	8.01	0.69	P	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15642	15642	T	G	MI.10235	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	896	299	L	R	cTc/cGc	-0.06	0	0	probably_damaging	1	neutral	0.05	neutral	2.72	deleterious	-3.52	deleterious	-3.45	high_impact	4.82	0.94	neutral	0.41	neutral	4.24	23.90	deleterious	0.02	0.35	0.7	disease	0.89	disease	0.7	disease	0.72	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.47	medium_impact	3.18	high_impact	0.16	0.8	41.05	8.01	0.72	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15642	15642	T	C	MI.10236	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	896	299	L	P	cTc/cCc	-0.06	0	0	probably_damaging	1	neutral	0.11	neutral	2.7	deleterious	-3.76	deleterious	-4.05	high_impact	4.12	0.97	neutral	0.37	neutral	3.97	23.60	deleterious	0.03	0.35	0.77	disease	0.83	disease	0.7	disease	0.72	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.27	medium_impact	2.55	high_impact	0.20	0.8	41.05	8.01	0.46	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15644	15644	A	G	MI.10237	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	898	300	I	V	Atc/Gtc	-1.21	0	0	probably_damaging	0.96	neutral	0.53	neutral	2.99	neutral	-0.26	neutral	-0.14	neutral_impact	0.56	0.94	neutral	0.97	neutral	-0.49	0.24	neutral	0.38	0.5	0.27	neutral	0.08	neutral	0.39	neutral	0.29	neutral	4	0.96	neutral	0.29	neutral	-2	neutral	0.60	deleterious	-2.02	low_impact	0.25	medium_impact	-0.69	medium_impact	0.34	0.8	59.21	9.43	0.39	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15644	15644	A	T	MI.10238	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	898	300	I	F	Atc/Ttc	-1.21	0	0	probably_damaging	1	neutral	0.56	neutral	2.8	neutral	-2.33	deleterious	-2.61	medium_impact	3.44	0.77	neutral	0.44	neutral	3.70	23.30	deleterious	0.13	0.4	0.54	disease	0.75	disease	0.63	disease	0.66	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.78	deleterious	-3.53	low_impact	0.28	medium_impact	1.93	medium_impact	0.38	0.8	59.21	9.43	0.22	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15644	15644	A	C	MI.10239	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	898	300	I	L	Atc/Ctc	-1.21	0	0	probably_damaging	0.99	neutral	1	neutral	2.92	neutral	-0.9	neutral	-1.3	medium_impact	2.92	0.84	neutral	0.44	neutral	2.18	17.35	deleterious	0.24	0.45	0.26	neutral	0.67	disease	0.52	disease	0.56	disease	1	0.99	deleterious	0.51	deleterious	1	deleterious	0.53	deleterious	-2.59	low_impact	1.85	high_impact	1.46	medium_impact	0.34	0.8	59.21	9.43	0.19	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9008	9008	C	A	MI.1024	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	482	161	T	N	aCc/aAc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	4.22	neutral	-2.32	deleterious	-4.53	high_impact	3.93	0.62	neutral	0.53	neutral	3.80	23.40	deleterious	0.42	0.65	0.81	disease	0.84	disease	0.64	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-1.4	low_impact	2.27	high_impact	0.76	0.9	50.44	8.87	0.5	P	0.90	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15645	15645	T	C	MI.10240	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	899	300	I	T	aTc/aCc	-0.29	0	0	probably_damaging	1	neutral	0.18	neutral	2.81	neutral	-2.38	deleterious	-2.74	high_impact	4	0.85	neutral	0.52	neutral	3.51	23.10	deleterious	0.07	0.35	0.48	neutral	0.57	disease	0.62	disease	0.64	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	-0.14	medium_impact	2.44	high_impact	0.19	0.8	59.21	9.43	0.41	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15645	15645	T	G	MI.10241	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	899	300	I	S	aTc/aGc	-0.29	0	0	probably_damaging	1	neutral	0.33	neutral	2.8	neutral	-2.59	deleterious	-3.64	medium_impact	3.42	0.84	neutral	0.43	neutral	4.40	24.10	deleterious	0.03	0.35	0.38	neutral	0.77	disease	0.6	disease	0.66	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	0.06	medium_impact	1.91	medium_impact	0.25	0.8	59.21	9.43	0.3	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15645	15645	T	A	MI.10242	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	899	300	I	N	aTc/aAc	-0.29	0	0	probably_damaging	1	neutral	0.21	neutral	2.75	deleterious	-4.06	deleterious	-4.32	high_impact	4.25	0.83	neutral	0.45	neutral	4.56	24.40	deleterious	0.06	0.35	0.68	disease	0.75	disease	0.63	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.09	medium_impact	2.67	high_impact	0.27	0.8	59.21	9.43	0.41	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15646	15646	C	A	MI.10243	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	900	300	I	M	atC/atA	2.92	0.28	0	probably_damaging	1	neutral	0.4	neutral	2.8	neutral	-2.61	neutral	-1.7	medium_impact	3.28	0.84	neutral	0.35	neutral	3.84	23.40	deleterious	0.17	0.45	0.54	disease	0.6	disease	0.54	disease	0.5	disease	0	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	0.13	medium_impact	1.79	medium_impact	0.43	0.8	59.21	9.43	0.3	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15646	15646	C	G	MI.10244	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	900	300	I	M	atC/atG	2.92	0.28	0	probably_damaging	1	neutral	0.4	neutral	2.8	neutral	-2.61	neutral	-1.7	medium_impact	3.28	0.84	neutral	0.35	neutral	3.37	22.90	deleterious	0.17	0.45	0.54	disease	0.6	disease	0.54	disease	0.5	disease	0	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	0.13	medium_impact	1.79	medium_impact	0.43	0.8	59.21	9.43	0.3	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15647	15647	C	A	MI.10245	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	901	301	L	M	Cta/Ata	-6.02	0	0	probably_damaging	1	neutral	0.26	neutral	2.45	neutral	-2.86	neutral	-1.31	high_impact	4.22	0.87	neutral	0.1	damaging	3.77	23.40	deleterious	0.17	0.45	0.49	neutral	0.54	disease	0.54	disease	0.61	disease	2	1	deleterious	0.13	neutral	2	deleterious	0.72	deleterious	-3.53	low_impact	-0.02	medium_impact	2.64	high_impact	0.52	0.8	59.47	8.53	0.38	N	0.98	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15647	15647	C	G	MI.10246	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	901	301	L	V	Cta/Gta	-6.02	0	0	probably_damaging	0.99	neutral	0.55	neutral	2.48	neutral	-2.53	neutral	-1.97	high_impact	4.29	0.87	neutral	0.11	damaging	3.24	22.80	deleterious	0.21	0.45	0.65	disease	0.54	disease	0.63	disease	0.63	disease	3	0.99	deleterious	0.28	neutral	2	deleterious	0.76	deleterious	-2.59	low_impact	0.27	medium_impact	2.7	high_impact	0.40	0.8	59.47	8.53	0.31	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15648	15648	T	G	MI.10247	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	902	301	L	R	cTa/cGa	-0.29	0	0	probably_damaging	1	neutral	0.17	neutral	2.37	deleterious	-5.09	deleterious	-3.94	high_impact	5.26	0.87	neutral	0.06	damaging	4.24	23.90	deleterious	0.03	0.35	0.94	disease	0.84	disease	0.75	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.15	medium_impact	3.58	high_impact	0.12	0.8	59.47	8.53	0.69	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15648	15648	T	A	MI.10248	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	902	301	L	Q	cTa/cAa	-0.29	0	0	probably_damaging	1	neutral	0.13	neutral	2.37	deleterious	-5.19	deleterious	-3.94	high_impact	4.92	0.86	neutral	0.07	damaging	4.15	23.80	deleterious	0.04	0.35	0.94	disease	0.71	disease	0.64	disease	0.67	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.23	medium_impact	3.27	high_impact	0.22	0.8	59.47	8.53	0.62	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15648	15648	T	C	MI.10249	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	902	301	L	P	cTa/cCa	-0.29	0	0	probably_damaging	1	neutral	0.19	neutral	2.36	deleterious	-5.43	deleterious	-4.6	high_impact	4.22	0.87	neutral	0.05	damaging	4.00	23.60	deleterious	0.03	0.35	0.95	disease	0.73	disease	0.7	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.12	medium_impact	2.64	high_impact	0.23	0.8	59.47	8.53	0.4	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9008	9008	C	G	MI.1025	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	482	161	T	S	aCc/aGc	7.07	1	0	probably_damaging	0.99	neutral	0.1	neutral	4.27	neutral	-0.63	deleterious	-3.59	medium_impact	2.08	0.6	damaging	0.64	neutral	3.56	23.10	deleterious	0.48	0.65	0.67	disease	0.71	disease	0.52	disease	0.56	disease	1	0.99	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	-0.25	medium_impact	0.69	medium_impact	0.78	0.9	50.44	8.87	0.52	P	0.88	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15650	15650	G	A	MI.10250	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	904	302	A	T	Gca/Aca	-2.58	0	0	benign	0	neutral	0.18	neutral	2.88	neutral	-1.45	neutral	-0.21	low_impact	1.42	0.92	neutral	0.88	neutral	2.69	20.70	deleterious	0.22	0.45	0.37	neutral	0.36	neutral	0.4	neutral	0.46	neutral	1	0.82	neutral	0.59	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	-0.14	medium_impact	0.1	medium_impact	0.71	0.85	17.37	20.13	0.44	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15650	15650	G	C	MI.10251	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	904	302	A	P	Gca/Cca	-2.58	0	0	benign	0.27	neutral	0.14	neutral	2.83	deleterious	-3.33	neutral	-1.35	medium_impact	2.97	0.84	neutral	0.29	neutral	2.64	20.40	deleterious	0.05	0.35	0.64	disease	0.86	disease	0.64	disease	0.77	disease	5	0.83	neutral	0.44	neutral	-3	neutral	0.71	deleterious	-0.33	medium_impact	-0.21	medium_impact	1.5	medium_impact	0.46	0.8	17.37	20.13	0.3	N	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15650	15650	G	T	MI.10252	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	904	302	A	S	Gca/Tca	-2.58	0	0	benign	0.1	neutral	0.29	neutral	2.87	neutral	-1.78	neutral	-0.44	low_impact	1.87	0.89	neutral	0.53	neutral	2.15	17.21	deleterious	0.27	0.45	0.41	neutral	0.48	neutral	0.49	neutral	0.49	neutral	0	0.67	neutral	0.6	deleterious	-6	neutral	0.23	neutral	0.16	medium_impact	0.01	medium_impact	0.51	medium_impact	0.36	0.8	17.37	20.13	0.38	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15651	15651	C	T	MI.10253	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	905	302	A	V	gCa/gTa	-2.58	0	0	benign	0	neutral	0.35	neutral	2.96	neutral	-0.35	neutral	0.77	neutral_impact	0.78	0.94	neutral	0.86	neutral	2.40	18.81	deleterious	0.17	0.45	0.29	neutral	0.59	disease	0.3	neutral	0.34	neutral	3	0.65	neutral	0.68	deleterious	-6	neutral	0.17	neutral	2.07	high_impact	0.08	medium_impact	-0.49	medium_impact	0.68	0.85	17.37	20.13	0.37	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15651	15651	C	A	MI.10254	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	905	302	A	E	gCa/gAa	-2.58	0	0	benign	0.29	neutral	0.1	neutral	2.84	neutral	-2.78	neutral	-1.2	medium_impact	3.31	0.82	neutral	0.43	neutral	3.37	22.90	deleterious	0.04	0.35	0.49	neutral	0.8	disease	0.62	disease	0.74	disease	5	0.88	neutral	0.41	neutral	-3	neutral	0.54	deleterious	-0.37	medium_impact	-0.3	medium_impact	1.81	medium_impact	0.28	0.8	17.37	20.13	0.32	N	0.84	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15651	15651	C	G	MI.10255	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	905	302	A	G	gCa/gGa	-2.58	0	0	benign	0.04	neutral	0.13	neutral	2.84	neutral	-2.82	neutral	-1.53	low_impact	1.73	0.9	neutral	0.53	neutral	1.06	11.02	neutral	0.22	0.45	0.56	disease	0.54	disease	0.5	neutral	0.46	neutral	1	0.86	neutral	0.55	deleterious	-6	neutral	0.26	neutral	0.56	medium_impact	-0.23	medium_impact	0.38	medium_impact	0.48	0.8	17.37	20.13	0.38	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15653	15653	A	G	MI.10256	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	907	303	M	V	Ata/Gta	-7.85	0	0.01	benign	0	neutral	0.64	neutral	3.13	neutral	1.57	neutral	0.16	neutral_impact	-1.01	0.94	neutral	0.98	neutral	-0.40	0.38	neutral	0.25	0.45	0.16	neutral	0.24	neutral	0.37	neutral	0.41	neutral	2	0.35	neutral	0.82	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	0.36	medium_impact	-2.11	low_impact	0.23	0.8	20.79	19.17	0.33	N	0.01	polymorphism	1	0.01	rs878890251	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15653	15653	A	C	MI.10257	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	907	303	M	L	Ata/Cta	-7.85	0	0.01	benign	0.02	neutral	1	neutral	3.25	neutral	2.72	neutral	0.52	neutral_impact	-2.21	0.93	neutral	0.95	neutral	-1.16	0.01	neutral	0.25	0.45	0.25	neutral	0.17	neutral	0.32	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.12	neutral	0.85	medium_impact	1.85	high_impact	-3.2	low_impact	0.19	0.8	20.79	19.17	0.33	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15653	15653	A	T	MI.10258	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	907	303	M	L	Ata/Tta	-7.85	0	0.01	benign	0.02	neutral	1	neutral	3.25	neutral	2.72	neutral	0.52	neutral_impact	-2.21	0.93	neutral	0.95	neutral	-1.00	0.02	neutral	0.25	0.45	0.25	neutral	0.17	neutral	0.32	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.12	neutral	0.85	medium_impact	1.85	high_impact	-3.2	low_impact	0.19	0.8	20.79	19.17	0.33	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15654	15654	T	C	MI.10259	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	908	303	M	T	aTa/aCa	-13.58	0	0	benign	0	neutral	0.31	neutral	3.03	neutral	0.2	neutral	-1.43	neutral_impact	-0.05	0.92	neutral	0.83	neutral	0.12	3.87	deleterious	0.11	0.4	0.18	neutral	0.28	neutral	0.39	neutral	0.42	neutral	2	0.69	neutral	0.66	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.03	medium_impact	-1.24	low_impact	0.10	0.8	20.79	19.17	0.39	N	0.02	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9008	9008	C	T	MI.1026	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	482	161	T	I	aCc/aTc	7.07	1	0	probably_damaging	1	neutral	0.12	neutral	4.28	neutral	-0.31	deleterious	-5.43	medium_impact	2.78	0.69	neutral	0.62	neutral	3.97	23.60	deleterious	0.4	0.65	0.55	disease	0.87	disease	0.6	disease	0.71	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.2	medium_impact	1.29	medium_impact	0.70	0.9	50.44	8.87	0.46	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15654	15654	T	A	MI.10260	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	908	303	M	K	aTa/aAa	-13.58	0	0	benign	0.11	neutral	0.25	neutral	2.97	neutral	-1.38	neutral	-2.44	low_impact	1.9	0.82	neutral	0.51	neutral	2.36	18.58	deleterious	0.03	0.35	0.4	neutral	0.64	disease	0.64	disease	0.7	disease	4	0.71	neutral	0.57	deleterious	-6	neutral	0.27	neutral	0.12	medium_impact	-0.04	medium_impact	0.53	medium_impact	0.17	0.8	20.79	19.17	0.33	N	0.24	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15655	15655	A	C	MI.10261	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	909	303	M	I	atA/atC	1.08	0	0	benign	0.04	neutral	0.57	neutral	3.1	neutral	1.53	neutral	0.42	neutral_impact	-1.55	0.93	neutral	0.98	neutral	-0.68	0.08	neutral	0.25	0.45	0.19	neutral	0.22	neutral	0.29	neutral	0.38	neutral	2	0.38	neutral	0.77	deleterious	-6	neutral	0.14	neutral	0.56	medium_impact	0.29	medium_impact	-2.6	low_impact	0.26	0.8	20.79	19.17	0.37	N	0.02	disease_causing	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15655	15655	A	T	MI.10262	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	909	303	M	I	atA/atT	1.08	0	0	benign	0.04	neutral	0.57	neutral	3.1	neutral	1.53	neutral	0.42	neutral_impact	-1.55	0.93	neutral	0.98	neutral	-0.62	0.11	neutral	0.25	0.45	0.19	neutral	0.22	neutral	0.29	neutral	0.38	neutral	2	0.38	neutral	0.77	deleterious	-6	neutral	0.14	neutral	0.56	medium_impact	0.29	medium_impact	-2.6	low_impact	0.26	0.8	20.79	19.17	0.37	N	0.02	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15656	15656	A	T	MI.10263	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	910	304	I	F	Atc/Ttc	-16.1	0	0	possibly_damaging	0.84	neutral	0.57	neutral	2.99	neutral	-0.08	neutral	-1.91	low_impact	0.88	0.97	neutral	0.84	neutral	2.01	16.31	deleterious	0.18	0.45	0.38	neutral	0.49	neutral	0.42	neutral	0.45	neutral	1	0.81	neutral	0.37	neutral	-3	neutral	0.66	deleterious	-1.4	low_impact	0.29	medium_impact	-0.39	medium_impact	0.42	0.8	10.79	21.01	0.3	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15656	15656	A	C	MI.10264	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	910	304	I	L	Atc/Ctc	-16.1	0	0	benign	0.23	neutral	0.97	neutral	3.39	neutral	2.15	neutral	-0.66	neutral_impact	-0.41	0.94	neutral	0.9	neutral	0.33	5.98	deleterious	0.24	0.45	0.16	neutral	0.29	neutral	0.29	neutral	0.44	neutral	1	0.17	neutral	0.87	deleterious	-6	neutral	0.19	neutral	-0.24	medium_impact	1.04	medium_impact	-1.57	low_impact	0.49	0.8	10.79	21.01	0.33	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15656	15656	A	G	MI.10265	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	910	304	I	V	Atc/Gtc	-16.1	0	0	benign	0.1	neutral	0.73	neutral	3.07	neutral	0.67	neutral	0	neutral_impact	-0.05	0.98	neutral	0.92	neutral	-1.17	0.01	neutral	0.4	0.5	0.25	neutral	0.06	neutral	0.35	neutral	0.23	neutral	5	0.16	neutral	0.82	deleterious	-6	neutral	0.15	neutral	0.16	medium_impact	0.46	medium_impact	-1.24	low_impact	0.37	0.8	10.79	21.01	0.4	N	0.59	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15657	15657	T	A	MI.10266	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	911	304	I	N	aTc/aAc	-1.44	0	0	possibly_damaging	0.81	neutral	0.26	neutral	2.89	neutral	-2.68	deleterious	-3.35	medium_impact	2.79	0.93	neutral	0.51	neutral	4.68	24.50	deleterious	0.19	0.45	0.71	disease	0.63	disease	0.64	disease	0.7	disease	4	0.86	neutral	0.23	neutral	0	NA	0.71	deleterious	-1.32	low_impact	-0.02	medium_impact	1.34	medium_impact	0.22	0.8	10.79	21.01	0.4	N	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15657	15657	T	G	MI.10267	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	911	304	I	S	aTc/aGc	-1.44	0	0	possibly_damaging	0.61	neutral	0.68	neutral	2.92	neutral	-1.4	deleterious	-2.66	medium_impact	2.64	0.97	neutral	0.52	neutral	4.29	24.00	deleterious	0.08	0.35	0.54	disease	0.58	disease	0.54	disease	0.58	disease	2	0.53	neutral	0.54	deleterious	0	NA	0.60	deleterious	-0.91	medium_impact	0.4	medium_impact	1.2	medium_impact	0.17	0.8	10.79	21.01	0.22	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15657	15657	T	C	MI.10268	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	911	304	I	T	aTc/aCc	-1.44	0	0	benign	0.07	neutral	0.29	neutral	2.93	neutral	-1.12	neutral	-1.84	medium_impact	2.13	0.98	neutral	0.7	neutral	3.35	22.90	deleterious	0.14	0.4	0.47	neutral	0.35	neutral	0.43	neutral	0.46	neutral	1	0.68	neutral	0.61	deleterious	-3	neutral	0.19	neutral	0.32	medium_impact	0.01	medium_impact	0.74	medium_impact	0.19	0.8	10.79	21.01	0.45	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15658	15658	C	A	MI.10269	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	912	304	I	M	atC/atA	2.46	0.04	0	probably_damaging	0.92	neutral	0.17	neutral	2.95	neutral	-0.78	neutral	-0.71	neutral_impact	0.08	0.96	neutral	0.9	neutral	2.01	16.26	deleterious	0.33	0.5	0.26	neutral	0.23	neutral	0.31	neutral	0.42	neutral	2	0.96	neutral	0.13	neutral	-2	neutral	0.64	deleterious	-1.72	low_impact	-0.15	medium_impact	-1.12	low_impact	0.49	0.8	10.79	21.01	0.52	N	0.26	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9010	9010	G	A	MI.1027	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	484	162	A	T	Gct/Act	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	3.46	deleterious	-4.91	deleterious	-3.55	high_impact	3.62	0.47	damaging	0.43	neutral	4.32	24.00	deleterious	0.37	0.65	0.88	disease	0.85	disease	0.67	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.01	high_impact	0.75	0.9	49.56	8.89	0.35	N	0.80	disease_causing	0.65	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15658	15658	C	G	MI.10270	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	912	304	I	M	atC/atG	2.46	0.04	0	probably_damaging	0.92	neutral	0.17	neutral	2.95	neutral	-0.78	neutral	-0.71	neutral_impact	0.08	0.96	neutral	0.9	neutral	1.57	13.71	neutral	0.33	0.5	0.26	neutral	0.23	neutral	0.31	neutral	0.42	neutral	2	0.96	neutral	0.13	neutral	-2	neutral	0.64	deleterious	-1.72	low_impact	-0.15	medium_impact	-1.12	low_impact	0.49	0.8	10.79	21.01	0.53	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15659	15659	C	G	MI.10271	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	913	305	P	A	Ccc/Gcc	-6.94	0	0	probably_damaging	1	neutral	0.43	neutral	1.38	deleterious	-6.19	deleterious	-5.17	high_impact	4.01	0.87	neutral	0.11	damaging	2.97	22.10	deleterious	0.16	0.45	0.5	neutral	0.6	disease	0.68	disease	0.65	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	0.16	medium_impact	2.45	high_impact	0.46	0.8	55	8.37	0.32	N	0.84	polymorphism	1	0.11	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15659	15659	C	A	MI.10272	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	913	305	P	T	Ccc/Acc	-6.94	0	0	probably_damaging	1	neutral	0.35	neutral	1.35	deleterious	-7.4	deleterious	-5.17	high_impact	4.95	0.82	neutral	0.08	damaging	3.74	23.30	deleterious	0.14	0.4	0.55	disease	0.77	disease	0.63	disease	0.65	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.08	medium_impact	3.3	high_impact	0.33	0.8	55	8.37	0.57	P	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15659	15659	C	T	MI.10273	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	913	305	P	S	Ccc/Tcc	-6.94	0	0	probably_damaging	1	neutral	0.49	neutral	1.38	deleterious	-6.14	deleterious	-5.17	high_impact	3.6	0.84	neutral	0.07	damaging	3.96	23.60	deleterious	0.15	0.45	0.53	disease	0.77	disease	0.68	disease	0.66	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.21	medium_impact	2.08	high_impact	0.12	0.8	55	8.37	0.24	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15660	15660	C	A	MI.10274	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	914	305	P	H	cCc/cAc	7.04	1	0	probably_damaging	1	neutral	0.44	neutral	1.34	deleterious	-8.9	deleterious	-5.83	high_impact	5.29	0.84	neutral	0.07	damaging	4.13	23.80	deleterious	0.09	0.35	0.73	disease	0.84	disease	0.79	disease	0.69	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.17	medium_impact	3.61	high_impact	0.23	0.8	55	8.37	0.7	P	0.71	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15660	15660	C	G	MI.10275	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	914	305	P	R	cCc/cGc	7.04	1	0	probably_damaging	1	neutral	0.33	neutral	1.35	deleterious	-7.83	deleterious	-5.83	high_impact	5.29	0.82	neutral	0.05	damaging	3.68	23.30	deleterious	0.06	0.35	0.45	neutral	0.88	disease	0.79	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.06	medium_impact	3.61	high_impact	0.24	0.8	55	8.37	0.66	P	0.80	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15660	15660	C	T	MI.10276	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	914	305	P	L	cCc/cTc	7.04	1	0	probably_damaging	1	neutral	1	neutral	1.36	deleterious	-7.06	deleterious	-6.47	high_impact	4.32	0.85	neutral	0.05	damaging	4.50	24.30	deleterious	0.07	0.35	0.53	disease	0.84	disease	0.66	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.80	deleterious	-3.53	low_impact	1.85	high_impact	2.73	high_impact	0.64	0.8	55	8.37	0.44	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15662	15662	A	G	MI.10277	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	916	306	I	V	Atc/Gtc	-12.9	0	0.06	benign	0	neutral	0.5	neutral	3.16	neutral	-0.03	neutral	-0.39	neutral_impact	0.51	0.98	neutral	0.88	neutral	0.27	5.40	deleterious	0.4	0.5	0.22	neutral	0.23	neutral	0.37	neutral	0.43	neutral	1	0.5	neutral	0.75	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.22	medium_impact	-0.73	medium_impact	0.24	0.8	18.95	20.19	0.39	N	0.01	polymorphism	1	0.01	rs3094280	.	.	.	.	breast tumor	.	.	0.59	A15662G	Complex mitochondriopathy-associated	+	+	Reported	1	N	P	N,P	neutral
chrM	15662	15662	A	C	MI.10278	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	916	306	I	L	Atc/Ctc	-12.9	0	0.06	benign	0.01	neutral	0.66	neutral	3.27	neutral	0.99	neutral	0.04	neutral_impact	-0.94	0.97	neutral	0.94	neutral	-0.60	0.12	neutral	0.28	0.45	0.16	neutral	0.15	neutral	0.24	neutral	0.23	neutral	5	0.32	neutral	0.83	deleterious	-6	neutral	0.12	neutral	1.13	medium_impact	0.38	medium_impact	-2.05	low_impact	0.40	0.8	18.95	20.19	0.39	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15662	15662	A	T	MI.10279	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	916	306	I	F	Atc/Ttc	-12.9	0	0.06	benign	0.17	neutral	0.7	neutral	3.31	neutral	0.77	neutral	-0.98	neutral_impact	-1.16	0.98	neutral	0.93	neutral	2.11	16.89	deleterious	0.22	0.45	0.18	neutral	0.27	neutral	0.25	neutral	0.44	neutral	1	0.18	neutral	0.77	deleterious	-6	neutral	0.24	neutral	-0.09	medium_impact	0.42	medium_impact	-2.25	low_impact	0.49	0.8	18.95	20.19	0.43	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9010	9010	G	T	MI.1028	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	484	162	A	S	Gct/Tct	-6.12	0	0	probably_damaging	0.99	deleterious	0.02	neutral	3.47	deleterious	-4.28	deleterious	-2.66	high_impact	3.62	0.51	damaging	0.57	neutral	3.81	23.40	deleterious	0.3	0.65	0.76	disease	0.86	disease	0.64	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-0.66	medium_impact	2.01	high_impact	0.76	0.9	49.56	8.89	0.36	N	0.95	polymorphism	0.55	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15663	15663	T	C	MI.10280	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	917	306	I	T	aTc/aCc	-14.27	0	0	benign	0	neutral	0.39	neutral	3.13	neutral	-1.15	neutral	-1.66	neutral_impact	0.79	1	neutral	0.89	neutral	0.83	9.68	deleterious	0.22	0.45	0.33	neutral	0.32	neutral	0.52	disease	0.48	neutral	0	0.61	neutral	0.7	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.12	medium_impact	-0.48	medium_impact	0.16	0.8	18.95	20.19	0.39	N	0.08	polymorphism	1	0.02	rs369851331	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15663	15663	T	G	MI.10281	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	917	306	I	S	aTc/aGc	-14.27	0	0	benign	0.07	neutral	0.4	neutral	3.11	neutral	-1.27	neutral	-2.09	medium_impact	2.06	0.97	neutral	0.62	neutral	4.02	23.60	deleterious	0.05	0.35	0.4	neutral	0.54	disease	0.6	disease	0.61	disease	2	0.55	neutral	0.67	deleterious	-3	neutral	0.20	neutral	0.32	medium_impact	0.13	medium_impact	0.68	medium_impact	0.14	0.8	18.95	20.19	0.29	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15663	15663	T	A	MI.10282	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	917	306	I	N	aTc/aAc	-14.27	0	0	benign	0.17	neutral	0.31	neutral	3.09	neutral	-2.62	deleterious	-2.87	medium_impact	2.96	0.93	neutral	0.55	neutral	4.29	24.00	deleterious	0.13	0.4	0.38	neutral	0.54	disease	0.63	disease	0.68	disease	4	0.63	neutral	0.57	deleterious	-3	neutral	0.27	neutral	-0.09	medium_impact	0.03	medium_impact	1.49	medium_impact	0.15	0.8	18.95	20.19	0.37	N	0.32	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15664	15664	C	A	MI.10283	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	918	306	I	M	atC/atA	1.08	0	0	benign	0.02	neutral	0.22	neutral	3.12	neutral	-1.33	neutral	-0.38	neutral_impact	-0.03	0.94	neutral	0.91	neutral	2.08	16.70	deleterious	0.37	0.5	0.28	neutral	0.18	neutral	0.3	neutral	0.34	neutral	3	0.77	neutral	0.6	deleterious	-6	neutral	0.14	neutral	0.85	medium_impact	-0.08	medium_impact	-1.22	low_impact	0.49	0.8	18.95	20.19	0.46	N	0.01	polymorphism	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15664	15664	C	G	MI.10284	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	918	306	I	M	atC/atG	1.08	0	0	benign	0.02	neutral	0.22	neutral	3.12	neutral	-1.33	neutral	-0.38	neutral_impact	-0.03	0.94	neutral	0.91	neutral	1.60	13.86	neutral	0.37	0.5	0.28	neutral	0.18	neutral	0.3	neutral	0.34	neutral	3	0.77	neutral	0.6	deleterious	-6	neutral	0.14	neutral	0.85	medium_impact	-0.08	medium_impact	-1.22	low_impact	0.49	0.8	18.95	20.19	0.46	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15665	15665	C	G	MI.10285	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	919	307	L	V	Ctc/Gtc	-13.81	0	0	probably_damaging	0.98	neutral	0.4	neutral	2.78	neutral	-2.07	neutral	-1.75	medium_impact	2.83	0.94	neutral	0.19	damaging	1.86	15.36	deleterious	0.29	0.45	0.39	neutral	0.71	disease	0.41	neutral	0.36	neutral	3	0.98	neutral	0.21	neutral	1	deleterious	0.73	deleterious	-2.31	low_impact	0.13	medium_impact	1.38	medium_impact	0.39	0.8	21.58	13.46	0.26	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15665	15665	C	T	MI.10286	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	919	307	L	F	Ctc/Ttc	-13.81	0	0	probably_damaging	1	neutral	0.74	neutral	2.69	deleterious	-3.01	neutral	-2.44	medium_impact	3.26	0.96	neutral	0.13	damaging	3.94	23.50	deleterious	0.17	0.45	0.43	neutral	0.71	disease	0.45	neutral	0.34	neutral	3	1	deleterious	0.37	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.47	medium_impact	1.77	medium_impact	0.41	0.8	21.58	13.46	0.2	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15665	15665	C	A	MI.10287	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	919	307	L	I	Ctc/Atc	-13.81	0	0	probably_damaging	0.99	neutral	0.62	neutral	2.77	neutral	-1.49	neutral	-1.16	low_impact	1.89	0.96	neutral	0.7	neutral	2.74	21.00	deleterious	0.33	0.5	0.38	neutral	0.71	disease	0.37	neutral	0.2	neutral	6	0.99	deleterious	0.32	neutral	-2	neutral	0.73	deleterious	-2.59	low_impact	0.34	medium_impact	0.52	medium_impact	0.36	0.8	21.58	13.46	0.24	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15666	15666	T	A	MI.10288	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	920	307	L	H	cTc/cAc	0.86	0.27	0	probably_damaging	1	neutral	0.44	neutral	2.64	deleterious	-5.08	deleterious	-4.29	high_impact	4.59	0.93	neutral	0.09	damaging	4.20	23.90	deleterious	0.06	0.35	0.82	disease	0.83	disease	0.73	disease	0.69	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.17	medium_impact	2.97	high_impact	0.19	0.8	21.58	13.46	0.49	N	0.95	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15666	15666	T	G	MI.10289	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	920	307	L	R	cTc/cGc	0.86	0.27	0	probably_damaging	1	neutral	0.27	neutral	2.66	deleterious	-4.27	deleterious	-3.68	high_impact	4.39	0.94	neutral	0.07	damaging	4.24	23.90	deleterious	0.03	0.35	0.77	disease	0.92	disease	0.76	disease	0.75	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.01	medium_impact	2.79	high_impact	0.13	0.8	21.58	13.46	0.51	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9010	9010	G	C	MI.1029	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	484	162	A	P	Gct/Cct	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	3.43	deleterious	-5.82	deleterious	-4.54	high_impact	4.25	0.4	damaging	0.44	neutral	3.97	23.60	deleterious	0.16	0.65	0.95	disease	0.9	disease	0.77	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.54	high_impact	0.61	0.9	49.56	8.89	0.62	P	0.97	disease_causing	0.87	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15666	15666	T	C	MI.10290	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	920	307	L	P	cTc/cCc	0.86	0.27	0	probably_damaging	1	neutral	0.3	neutral	2.64	deleterious	-4.5	deleterious	-4.28	high_impact	4.39	0.93	neutral	0.07	damaging	3.97	23.60	deleterious	0.02	0.35	0.82	disease	0.86	disease	0.76	disease	0.72	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.02	medium_impact	2.79	high_impact	0.23	0.8	21.58	13.46	0.5	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15668	15668	C	A	MI.10291	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	922	308	H	N	Cat/Aat	-20	0	0	probably_damaging	1	neutral	0.33	neutral	3.15	neutral	0.75	deleterious	-4.4	medium_impact	2.12	0.89	neutral	0.18	damaging	3.70	23.30	deleterious	0.31	0.45	0.32	neutral	0.68	disease	0.54	disease	0.26	neutral	5	1	deleterious	0.17	neutral	1	deleterious	0.71	deleterious	-3.53	low_impact	0.06	medium_impact	0.73	medium_impact	0.26	0.8	53.42	10.01	0.32	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15668	15668	C	G	MI.10292	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	922	308	H	D	Cat/Gat	-20	0	0	probably_damaging	1	neutral	0.22	neutral	3.29	neutral	3.37	deleterious	-5.71	low_impact	1.77	0.84	neutral	0.09	damaging	3.82	23.40	deleterious	0.05	0.35	0.2	neutral	0.83	disease	0.72	disease	0.69	disease	4	1	deleterious	0.11	neutral	-2	neutral	0.71	deleterious	-3.53	low_impact	-0.08	medium_impact	0.41	medium_impact	0.35	0.8	53.42	10.01	0.26	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15668	15668	C	T	MI.10293	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	922	308	H	Y	Cat/Tat	-20	0	0	probably_damaging	1	neutral	1	neutral	3.07	neutral	-0.8	deleterious	-3.83	medium_impact	3.25	0.91	neutral	0.13	damaging	3.49	23.10	deleterious	0.2	0.45	0.39	neutral	0.8	disease	0.65	disease	0.55	disease	1	1	deleterious	0.5	deleterious	1	deleterious	0.75	deleterious	-3.53	low_impact	1.85	high_impact	1.76	medium_impact	0.21	0.8	53.42	10.01	0.19	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15669	15669	A	C	MI.10294	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	923	308	H	P	cAt/cCt	5.44	1	0	probably_damaging	1	neutral	0.24	neutral	3.08	neutral	-0.76	deleterious	-6.37	high_impact	3.71	0.88	neutral	0.08	damaging	3.21	22.70	deleterious	0.04	0.35	0.49	neutral	0.87	disease	0.69	disease	0.7	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.05	medium_impact	2.18	high_impact	0.17	0.8	53.42	10.01	0.46	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15669	15669	A	G	MI.10295	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	923	308	H	R	cAt/cGt	5.44	1	0	probably_damaging	1	neutral	0.39	neutral	3.11	neutral	0.55	deleterious	-5.08	high_impact	4.2	0.87	neutral	0.09	damaging	2.81	21.40	deleterious	0.13	0.4	0.34	neutral	0.87	disease	0.67	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.12	medium_impact	2.62	high_impact	0.23	0.8	53.42	10.01	0.42	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15669	15669	A	T	MI.10296	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	923	308	H	L	cAt/cTt	5.44	1	0	probably_damaging	1	neutral	0.87	neutral	3.1	neutral	0.31	deleterious	-7.01	high_impact	3.94	0.88	neutral	0.1	damaging	3.68	23.30	deleterious	0.07	0.35	0.47	neutral	0.86	disease	0.69	disease	0.71	disease	4	1	deleterious	0.44	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.67	medium_impact	2.38	high_impact	0.14	0.8	53.42	10.01	0.43	N	0.92	polymorphism	1	0.05	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15670	15670	T	A	MI.10297	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	924	308	H	Q	caT/caA	8.42	1	0.02	probably_damaging	1	neutral	0.3	neutral	3.08	neutral	0.73	deleterious	-5.06	high_impact	3.94	0.96	neutral	0.52	neutral	3.39	23.00	deleterious	0.22	0.45	0.29	neutral	0.73	disease	0.55	disease	0.27	neutral	5	1	deleterious	0.15	neutral	2	deleterious	0.72	deleterious	-3.53	low_impact	0.02	medium_impact	2.38	high_impact	0.27	0.8	53.42	10.01	0.6	P	0.94	polymorphism	1	0.05	rs193302997	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	15670	15670	T	G	MI.10298	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	924	308	H	Q	caT/caG	8.42	1	0.02	probably_damaging	1	neutral	0.3	neutral	3.08	neutral	0.73	deleterious	-5.06	high_impact	3.94	0.96	neutral	0.52	neutral	3.30	22.90	deleterious	0.22	0.45	0.29	neutral	0.73	disease	0.55	disease	0.27	neutral	5	1	deleterious	0.15	neutral	2	deleterious	0.72	deleterious	-3.53	low_impact	0.02	medium_impact	2.38	high_impact	0.27	0.8	53.42	10.01	0.59	P	0.94	polymorphism	1	0.05	rs193302997	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	15671	15671	A	G	MI.10299	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	925	309	M	V	Ata/Gta	-2.35	0	0	benign	0	neutral	0.5	neutral	3.22	neutral	1.08	neutral	0.15	neutral_impact	0.74	0.97	neutral	0.89	neutral	0.80	9.49	deleterious	0.25	0.45	0.24	neutral	0.7	disease	0.31	neutral	0.5	neutral	0	0.5	neutral	0.75	deleterious	-6	neutral	0.19	neutral	2.07	high_impact	0.22	medium_impact	-0.52	medium_impact	0.18	0.8	23.16	41.47	0.29	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8573	8573	G	C	MI.103	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	47	16	G	A	gGc/gCc	6.14	1	0	possibly_damaging	0.64	neutral	0.08	neutral	4.66	neutral	0.1	deleterious	-4.82	medium_impact	3.12	0.81	neutral	0.37	neutral	2.57	19.90	deleterious	0.46	0.65	0.5	neutral	0.68	disease	0.61	disease	0.61	disease	2	0.92	neutral	0.22	neutral	0	NA	0.64	deleterious	-0.99	medium_impact	-0.31	medium_impact	1.58	medium_impact	0.70	0.9	17.26	11.64	0.57	P	0.76	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9011	9011	C	G	MI.1030	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	485	162	A	G	gCt/gGt	9.38	1	0	probably_damaging	0.99	deleterious	0.01	neutral	3.78	neutral	-1.56	deleterious	-3.6	medium_impact	3.49	0.53	damaging	0.53	neutral	4.08	23.70	deleterious	0.27	0.65	0.45	neutral	0.83	disease	0.62	disease	0.69	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-2.65	low_impact	-0.84	medium_impact	1.89	medium_impact	0.85	0.9	49.56	8.89	0.51	P	0.86	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15671	15671	A	C	MI.10300	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	925	309	M	L	Ata/Cta	-2.35	0	0	benign	0.02	neutral	0.66	neutral	3.26	neutral	1.36	neutral	-0.22	neutral_impact	-0.4	0.97	neutral	0.95	neutral	0.18	4.44	deleterious	0.24	0.45	0.19	neutral	0.54	disease	0.26	neutral	0.35	neutral	3	0.3	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.85	medium_impact	0.38	medium_impact	-1.56	low_impact	0.20	0.8	23.16	41.47	0.33	N	0.16	polymorphism	1	0.00	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15671	15671	A	T	MI.10301	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	925	309	M	L	Ata/Tta	-2.35	0	0	benign	0.02	neutral	0.66	neutral	3.26	neutral	1.36	neutral	-0.22	neutral_impact	-0.4	0.97	neutral	0.95	neutral	0.28	5.47	deleterious	0.24	0.45	0.19	neutral	0.54	disease	0.26	neutral	0.35	neutral	3	0.3	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.85	medium_impact	0.38	medium_impact	-1.56	low_impact	0.20	0.8	23.16	41.47	0.34	N	0.16	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15672	15672	T	C	MI.10302	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	926	309	M	T	aTa/aCa	5.44	0.54	0.01	benign	0	neutral	0.41	neutral	3.3	neutral	1.93	neutral	2.4	neutral_impact	-2.31	1	neutral	0.98	neutral	-1.50	0.00	neutral	0.21	0.45	0.19	neutral	0.2	neutral	0.24	neutral	0.33	neutral	3	0.59	neutral	0.71	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.14	medium_impact	-3.29	low_impact	0.09	0.8	23.16	41.47	0.32	N	0.10	polymorphism	1	0.00	rs199967113	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15672	15672	T	A	MI.10303	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	926	309	M	K	aTa/aAa	5.44	0.54	0.01	benign	0.07	neutral	0.29	neutral	3.23	neutral	2.02	neutral	-0.06	neutral_impact	-1.04	0.96	neutral	0.74	neutral	1.14	11.41	neutral	0.08	0.35	0.19	neutral	0.76	disease	0.33	neutral	0.44	neutral	1	0.68	neutral	0.61	deleterious	-6	neutral	0.21	neutral	0.32	medium_impact	0.01	medium_impact	-2.14	low_impact	0.13	0.8	23.16	41.47	0.36	N	0.25	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15673	15673	A	C	MI.10304	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	927	309	M	I	atA/atC	-0.29	0	0	benign	0.02	neutral	0.4	neutral	3.21	neutral	0.86	neutral	-0.34	low_impact	1	0.96	neutral	0.62	neutral	1.72	14.52	neutral	0.24	0.45	0.23	neutral	0.74	disease	0.44	neutral	0.49	neutral	0	0.58	neutral	0.69	deleterious	-6	neutral	0.20	neutral	0.85	medium_impact	0.13	medium_impact	-0.29	medium_impact	0.31	0.8	23.16	41.47	0.28	N	0.11	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15673	15673	A	T	MI.10305	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	927	309	M	I	atA/atT	-0.29	0	0	benign	0.02	neutral	0.4	neutral	3.21	neutral	0.86	neutral	-0.34	low_impact	1	0.96	neutral	0.62	neutral	1.75	14.70	neutral	0.24	0.45	0.23	neutral	0.74	disease	0.44	neutral	0.49	neutral	0	0.58	neutral	0.69	deleterious	-6	neutral	0.20	neutral	0.85	medium_impact	0.13	medium_impact	-0.29	medium_impact	0.31	0.8	23.16	41.47	0.28	N	0.11	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15674	15674	T	G	MI.10306	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	928	310	S	A	Tcc/Gcc	-1.67	0	0.02	benign	0.02	neutral	0.51	neutral	2.79	neutral	-1.77	neutral	-1.51	medium_impact	2.19	0.96	neutral	0.88	neutral	2.18	17.37	deleterious	0.23	0.45	0.37	neutral	0.46	neutral	0.41	neutral	0.39	neutral	2	0.47	neutral	0.75	deleterious	-3	neutral	0.17	neutral	0.85	medium_impact	0.23	medium_impact	0.8	medium_impact	0.46	0.8	20.26	12.07	0.32	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15674	15674	T	C	MI.10307	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	928	310	S	P	Tcc/Ccc	-1.67	0	0.02	possibly_damaging	0.68	neutral	0.21	neutral	2.72	neutral	-2.73	deleterious	-2.98	high_impact	3.68	0.76	neutral	0.34	neutral	3.89	23.50	deleterious	0.06	0.35	0.7	disease	0.84	disease	0.5	neutral	0.67	disease	3	0.83	neutral	0.27	neutral	1	deleterious	0.56	deleterious	-1.04	low_impact	-0.09	medium_impact	2.15	high_impact	0.25	0.8	20.26	12.07	0.49	N	1.00	polymorphism	1	0.04	.	.	.	.	.	breast tumor	.	.	.	T15674C	LHON	+	-	Reported	2	.	P	P	damaging
chrM	15674	15674	T	A	MI.10308	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	928	310	S	T	Tcc/Acc	-1.67	0	0.02	benign	0.19	neutral	0.41	neutral	2.77	neutral	-2.09	neutral	-1.71	high_impact	3.51	0.87	neutral	0.61	neutral	2.16	17.24	deleterious	0.17	0.45	0.47	neutral	0.69	disease	0.38	neutral	0.41	neutral	2	0.51	neutral	0.61	deleterious	-2	neutral	0.26	neutral	-0.14	medium_impact	0.14	medium_impact	1.99	medium_impact	0.52	0.8	20.26	12.07	0.33	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15675	15675	C	A	MI.10309	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	929	310	S	Y	tCc/tAc	1.31	0.87	0	probably_damaging	0.95	neutral	1	neutral	2.71	deleterious	-4.18	deleterious	-3.6	high_impact	4.2	0.91	neutral	0.46	neutral	4.23	23.90	deleterious	0.05	0.35	0.63	disease	0.84	disease	0.67	disease	0.71	disease	4	0.95	neutral	0.53	deleterious	2	deleterious	0.76	deleterious	-1.92	low_impact	1.85	high_impact	2.62	high_impact	0.24	0.8	20.26	12.07	0.3	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9011	9011	C	A	MI.1031	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	485	162	A	D	gCt/gAt	9.38	1	0	probably_damaging	1	deleterious	0	neutral	3.43	deleterious	-6.89	deleterious	-5.37	high_impact	4.59	0.55	damaging	0.46	neutral	4.55	24.30	deleterious	0.13	0.65	0.97	disease	0.93	disease	0.75	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.84	high_impact	0.62	0.9	49.56	8.89	0.52	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15675	15675	C	G	MI.10310	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	929	310	S	C	tCc/tGc	1.31	0.87	0	probably_damaging	0.92	neutral	0.18	neutral	2.7	deleterious	-4.44	deleterious	-2.91	medium_impact	3.24	0.84	neutral	0.37	neutral	3.60	23.20	deleterious	0.07	0.35	0.75	disease	0.74	disease	0.55	disease	0.53	disease	1	0.95	neutral	0.13	neutral	1	deleterious	0.65	deleterious	-1.72	low_impact	-0.14	medium_impact	1.75	medium_impact	0.30	0.8	20.26	12.07	0.34	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15675	15675	C	T	MI.10311	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	929	310	S	F	tCc/tTc	1.31	0.87	0	probably_damaging	0.95	neutral	0.72	neutral	2.71	deleterious	-3.84	deleterious	-3.61	high_impact	4.04	0.91	neutral	0.48	neutral	4.23	23.90	deleterious	0.05	0.35	0.57	disease	0.84	disease	0.6	disease	0.68	disease	4	0.95	neutral	0.39	neutral	2	deleterious	0.75	deleterious	-1.92	low_impact	0.44	medium_impact	2.48	high_impact	0.09	0.8	20.26	12.07	0.29	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15677	15677	A	C	MI.10312	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	931	311	K	Q	Aaa/Caa	-15.19	0	0	probably_damaging	0.99	neutral	0.6	neutral	2.94	neutral	-1.58	neutral	-2.42	high_impact	3.83	0.9	neutral	0.14	damaging	1.93	15.79	deleterious	0.26	0.45	0.47	neutral	0.74	disease	0.66	disease	0.66	disease	3	0.99	deleterious	0.31	neutral	2	deleterious	0.74	deleterious	-2.59	low_impact	0.32	medium_impact	2.28	high_impact	0.26	0.8	17.63	17.74	0.23	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15677	15677	A	G	MI.10313	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	931	311	K	E	Aaa/Gaa	-15.19	0	0	probably_damaging	0.99	neutral	0.76	neutral	2.97	neutral	-0.79	neutral	-2.43	high_impact	3.56	0.8	neutral	0.17	damaging	3.71	23.30	deleterious	0.18	0.45	0.36	neutral	0.8	disease	0.65	disease	0.65	disease	3	0.99	deleterious	0.39	neutral	2	deleterious	0.76	deleterious	-2.59	low_impact	0.49	medium_impact	2.04	high_impact	0.26	0.8	17.63	17.74	0.19	N	0.95	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15678	15678	A	C	MI.10314	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	932	311	K	T	aAa/aCa	4.52	0.99	0	probably_damaging	1	neutral	0.69	neutral	2.97	neutral	-1.63	deleterious	-3.6	medium_impact	3.14	0.91	neutral	0.17	damaging	3.55	23.10	deleterious	0.06	0.35	0.49	neutral	0.77	disease	0.59	disease	0.55	disease	1	1	deleterious	0.35	neutral	1	deleterious	0.78	deleterious	-3.53	low_impact	0.41	medium_impact	1.66	medium_impact	0.16	0.8	17.63	17.74	0.39	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15678	15678	A	T	MI.10315	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	932	311	K	M	aAa/aTa	4.52	0.99	0	probably_damaging	1	neutral	0.27	neutral	2.92	deleterious	-3.65	deleterious	-3.66	high_impact	4.17	0.91	neutral	0.19	damaging	4.07	23.70	deleterious	0.07	0.35	0.73	disease	0.78	disease	0.59	disease	0.66	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	-0.01	medium_impact	2.59	high_impact	0.17	0.8	17.63	17.74	0.55	P	0.67	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15679	15679	A	C	MI.10316	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	933	311	K	N	aaA/aaC	8.42	1	0	probably_damaging	1	neutral	0.58	neutral	2.98	neutral	-1.78	deleterious	-2.92	medium_impact	2.42	0.93	neutral	0.78	neutral	2.75	21.10	deleterious	0.38	0.5	0.41	neutral	0.61	disease	0.47	neutral	0.21	neutral	6	1	deleterious	0.29	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	0.3	medium_impact	1	medium_impact	0.25	0.8	17.63	17.74	0.49	N	0.84	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15679	15679	A	T	MI.10317	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	933	311	K	N	aaA/aaT	8.42	1	0	probably_damaging	1	neutral	0.58	neutral	2.98	neutral	-1.78	deleterious	-2.92	medium_impact	2.42	0.93	neutral	0.78	neutral	2.79	21.30	deleterious	0.38	0.5	0.41	neutral	0.61	disease	0.47	neutral	0.21	neutral	6	1	deleterious	0.29	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	0.3	medium_impact	1	medium_impact	0.25	0.8	17.63	17.74	0.5	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15680	15680	C	G	MI.10318	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	934	312	Q	E	Caa/Gaa	0.63	0.99	0	benign	0.41	neutral	0.31	neutral	2.99	neutral	-0.37	neutral	-1.65	high_impact	3.6	0.9	neutral	0.12	damaging	1.51	13.34	neutral	0.24	0.45	0.42	neutral	0.66	disease	0.54	disease	0.59	disease	2	0.64	neutral	0.45	neutral	-2	neutral	0.46	deleterious	-0.58	medium_impact	0.03	medium_impact	2.08	high_impact	0.27	0.8	31.58	10.28	0.4	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15680	15680	C	A	MI.10319	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	934	312	Q	K	Caa/Aaa	0.63	0.99	0	possibly_damaging	0.67	neutral	0.48	neutral	3.01	neutral	0.26	neutral	-2.14	medium_impact	3.12	0.92	neutral	0.1	damaging	4.03	23.70	deleterious	0.21	0.45	0.38	neutral	0.8	disease	0.54	disease	0.62	disease	2	0.65	neutral	0.41	neutral	0	NA	0.68	deleterious	-1.02	low_impact	0.2	medium_impact	1.64	medium_impact	0.23	0.8	31.58	10.28	0.33	N	1.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9011	9011	C	T	MI.1032	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	485	162	A	V	gCt/gTt	9.38	1	0	probably_damaging	1	neutral	0.18	neutral	3.55	deleterious	-4.45	deleterious	-3.6	medium_impact	3.44	0.38	damaging	0.4	neutral	4.50	24.30	deleterious	0.37	0.65	0.58	disease	0.87	disease	0.67	disease	0.73	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.08	medium_impact	1.85	medium_impact	0.84	0.9	49.56	8.89	0.76	P	0.75	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15681	15681	A	T	MI.10320	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	935	312	Q	L	cAa/cTa	4.29	1	0	possibly_damaging	0.82	neutral	0.7	neutral	3.15	neutral	2.18	deleterious	-3.42	low_impact	1.56	0.97	neutral	0.43	neutral	3.59	23.20	deleterious	0.09	0.35	0.27	neutral	0.74	disease	0.48	neutral	0.37	neutral	3	0.79	neutral	0.44	neutral	-3	neutral	0.69	deleterious	-1.35	low_impact	0.42	medium_impact	0.22	medium_impact	0.15	0.8	31.58	10.28	0.42	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15681	15681	A	C	MI.10321	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	935	312	Q	P	cAa/cCa	4.29	1	0	probably_damaging	0.92	neutral	0.24	neutral	2.98	neutral	-1.09	deleterious	-3.32	high_impact	4.5	0.9	neutral	0.07	damaging	3.20	22.70	deleterious	0.06	0.35	0.64	disease	0.84	disease	0.57	disease	0.65	disease	3	0.94	neutral	0.16	neutral	2	deleterious	0.80	deleterious	-1.72	low_impact	-0.05	medium_impact	2.89	high_impact	0.26	0.8	31.58	10.28	0.49	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15681	15681	A	G	MI.10322	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	935	312	Q	R	cAa/cGa	4.29	1	0	benign	0.3	neutral	0.39	neutral	2.99	neutral	-0.31	neutral	-2.12	high_impact	3.81	0.9	neutral	0.13	damaging	3.40	23.00	deleterious	0.22	0.45	0.48	neutral	0.81	disease	0.47	neutral	0.52	disease	0	0.53	neutral	0.55	deleterious	-2	neutral	0.33	neutral	-0.39	medium_impact	0.12	medium_impact	2.27	high_impact	0.24	0.8	31.58	10.28	0.48	N	0.99	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15682	15682	A	C	MI.10323	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	936	312	Q	H	caA/caC	5.44	1	0	probably_damaging	0.92	neutral	0.54	neutral	2.98	neutral	-0.95	neutral	-2.41	medium_impact	2.52	0.88	neutral	0.09	damaging	3.24	22.80	deleterious	0.18	0.45	0.62	disease	0.63	disease	0.38	neutral	0.37	neutral	3	0.91	neutral	0.31	neutral	1	deleterious	0.76	deleterious	-1.72	low_impact	0.26	medium_impact	1.1	medium_impact	0.38	0.8	31.58	10.28	0.39	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15682	15682	A	T	MI.10324	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	936	312	Q	H	caA/caT	5.44	1	0	probably_damaging	0.92	neutral	0.54	neutral	2.98	neutral	-0.95	neutral	-2.41	medium_impact	2.52	0.88	neutral	0.09	damaging	3.44	23.00	deleterious	0.18	0.45	0.62	disease	0.63	disease	0.38	neutral	0.37	neutral	3	0.91	neutral	0.31	neutral	1	deleterious	0.76	deleterious	-1.72	low_impact	0.26	medium_impact	1.1	medium_impact	0.38	0.8	31.58	10.28	0.4	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15683	15683	C	G	MI.10325	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	937	313	Q	E	Caa/Gaa	2.46	1	0	probably_damaging	0.98	neutral	0.54	neutral	3.01	neutral	0.11	neutral	-0.92	medium_impact	2.34	0.92	neutral	0.51	neutral	1.37	12.63	neutral	0.29	0.45	0.24	neutral	0.61	disease	0.66	disease	0.7	disease	4	0.97	neutral	0.28	neutral	1	deleterious	0.72	deleterious	-2.31	low_impact	0.26	medium_impact	0.93	medium_impact	0.39	0.8	24.21	42.13	0.36	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15683	15683	C	A	MI.10326	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	937	313	Q	K	Caa/Aaa	2.46	1	0	probably_damaging	0.99	neutral	0.55	neutral	3.07	neutral	0.65	neutral	-0.06	neutral_impact	0.34	0.93	neutral	0.47	neutral	2.35	18.49	deleterious	0.25	0.45	0.18	neutral	0.67	disease	0.45	neutral	0.41	neutral	2	0.99	deleterious	0.28	neutral	-2	neutral	0.70	deleterious	-2.59	low_impact	0.27	medium_impact	-0.89	medium_impact	0.32	0.8	24.21	42.13	0.33	N	0.43	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15684	15684	A	G	MI.10327	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	938	313	Q	R	cAa/cGa	4.29	1	0	probably_damaging	0.99	neutral	0.51	neutral	3.1	neutral	0.9	neutral	1.4	neutral_impact	-1.88	0.96	neutral	0.91	neutral	-1.18	0.01	neutral	0.23	0.45	0.16	neutral	0.18	neutral	0.36	neutral	0.23	neutral	5	0.99	deleterious	0.26	neutral	-2	neutral	0.65	deleterious	-2.59	low_impact	0.23	medium_impact	-2.9	low_impact	0.28	0.8	24.21	42.13	0.44	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15684	15684	A	C	MI.10328	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	938	313	Q	P	cAa/cCa	4.29	1	0	probably_damaging	0.99	neutral	0.28	neutral	2.91	neutral	-2.03	neutral	-2.33	medium_impact	2	0.91	neutral	0.35	neutral	1.63	14.01	neutral	0.04	0.35	0.51	disease	0.84	disease	0.65	disease	0.78	disease	6	1	deleterious	0.15	neutral	1	deleterious	0.85	deleterious	-2.59	low_impact	0	medium_impact	0.62	medium_impact	0.16	0.8	24.21	42.13	0.43	N	0.97	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15684	15684	A	T	MI.10329	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	938	313	Q	L	cAa/cTa	4.29	1	0	probably_damaging	0.99	neutral	0.74	neutral	2.93	neutral	-1.16	neutral	-2.41	low_impact	1.22	0.96	neutral	0.54	neutral	1.89	15.55	deleterious	0.07	0.35	0.35	neutral	0.63	disease	0.62	disease	0.69	disease	4	0.99	deleterious	0.38	neutral	-2	neutral	0.75	deleterious	-2.59	low_impact	0.47	medium_impact	-0.09	medium_impact	0.11	0.8	24.21	42.13	0.39	N	0.86	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9013	9013	A	T	MI.1033	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	487	163	N	Y	Aac/Tac	-13.06	0	0	probably_damaging	1	deleterious	0	neutral	1.76	deleterious	-10.28	deleterious	-7.19	high_impact	4.63	0.52	damaging	0.05	damaging	3.85	23.40	deleterious	0.18	0.65	0.99	disease	0.93	disease	0.8	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.38	0.9	49.56	8.85	0.38	N	1.00	disease_causing	0.88	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15685	15685	A	C	MI.10330	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	939	313	Q	H	caA/caC	2.92	1	0	probably_damaging	1	neutral	0.57	neutral	2.91	neutral	-1.8	neutral	-1.19	medium_impact	2.14	0.94	neutral	0.52	neutral	3.13	22.60	deleterious	0.2	0.45	0.47	neutral	0.47	neutral	0.59	disease	0.47	neutral	1	1	deleterious	0.29	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.29	medium_impact	0.75	medium_impact	0.39	0.8	24.21	42.13	0.36	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15685	15685	A	T	MI.10331	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	939	313	Q	H	caA/caT	2.92	1	0	probably_damaging	1	neutral	0.57	neutral	2.91	neutral	-1.8	neutral	-1.19	medium_impact	2.14	0.94	neutral	0.52	neutral	3.23	22.80	deleterious	0.2	0.45	0.47	neutral	0.47	neutral	0.59	disease	0.47	neutral	1	1	deleterious	0.29	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.29	medium_impact	0.75	medium_impact	0.39	0.8	24.21	42.13	0.37	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15686	15686	A	C	MI.10332	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	940	314	S	R	Agc/Cgc	-0.98	0	0	probably_damaging	1	neutral	0.37	neutral	2.93	neutral	-1.87	neutral	-2.17	high_impact	3.96	0.95	neutral	0.4	neutral	3.81	23.40	deleterious	0.04	0.35	0.44	neutral	0.77	disease	0.71	disease	0.72	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.1	medium_impact	2.4	high_impact	0.43	0.8	48.16	12.57	0.38	N	1.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15686	15686	A	G	MI.10333	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	940	314	S	G	Agc/Ggc	-0.98	0	0	probably_damaging	1	neutral	0.35	neutral	3	neutral	-1.13	neutral	-0.41	low_impact	1.14	0.96	neutral	0.82	neutral	1.78	14.88	neutral	0.14	0.4	0.27	neutral	0.14	neutral	0.38	neutral	0.25	neutral	5	1	deleterious	0.18	neutral	-2	neutral	0.65	deleterious	-3.53	low_impact	0.08	medium_impact	-0.16	medium_impact	0.55	0.8	48.16	12.57	0.47	N	0.89	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15686	15686	A	T	MI.10334	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	940	314	S	C	Agc/Tgc	-0.98	0	0	probably_damaging	1	neutral	0.18	neutral	2.85	deleterious	-4.65	neutral	-2.3	high_impact	4.07	0.95	neutral	0.36	neutral	3.39	23.00	deleterious	0.06	0.35	0.66	disease	0.65	disease	0.6	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	-0.14	medium_impact	2.5	high_impact	0.30	0.8	48.16	12.57	0.45	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15687	15687	G	C	MI.10335	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	941	314	S	T	aGc/aCc	-0.06	0	0	probably_damaging	0.99	neutral	0.4	neutral	2.92	neutral	-2.08	neutral	-0.94	low_impact	1.32	0.97	neutral	0.68	neutral	0.72	8.93	deleterious	0.19	0.45	0.24	neutral	0.31	neutral	0.37	neutral	0.42	neutral	2	0.99	deleterious	0.21	neutral	-2	neutral	0.61	deleterious	-2.59	low_impact	0.13	medium_impact	0.01	medium_impact	0.51	0.8	48.16	12.57	0.4	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15687	15687	G	A	MI.10336	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	941	314	S	N	aGc/aAc	-0.06	0	0	probably_damaging	0.99	neutral	0.32	neutral	2.97	neutral	-1.37	neutral	-1.17	medium_impact	2.69	0.91	neutral	0.49	neutral	2.19	17.47	deleterious	0.37	0.5	0.35	neutral	0.53	disease	0.61	disease	0.56	disease	1	0.99	deleterious	0.17	neutral	1	deleterious	0.69	deleterious	-2.59	low_impact	0.05	medium_impact	1.25	medium_impact	0.35	0.8	48.16	12.57	0.37	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15687	15687	G	T	MI.10337	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	941	314	S	I	aGc/aTc	-0.06	0	0	probably_damaging	1	neutral	0.4	neutral	2.85	deleterious	-4.82	deleterious	-2.84	high_impact	4.07	0.95	neutral	0.46	neutral	4.25	23.90	deleterious	0.04	0.35	0.59	disease	0.81	disease	0.68	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.13	medium_impact	2.5	high_impact	0.44	0.8	48.16	12.57	0.39	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15689	15689	A	G	MI.10338	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	943	315	M	V	Ata/Gta	-1.21	0	0	probably_damaging	0.98	neutral	0.52	neutral	3.17	neutral	0.01	neutral	-1.32	medium_impact	1.97	0.85	neutral	0.19	damaging	1.10	11.23	neutral	0.28	0.45	0.31	neutral	0.57	disease	0.63	disease	0.58	disease	2	0.97	neutral	0.27	neutral	1	deleterious	0.68	deleterious	-2.31	low_impact	0.24	medium_impact	0.6	medium_impact	0.40	0.8	16.05	26	0.23	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15689	15689	A	C	MI.10339	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	943	315	M	L	Ata/Cta	-1.21	0	0	probably_damaging	0.96	neutral	0.71	neutral	3.27	neutral	0.96	neutral	-0.22	neutral_impact	-0.1	0.94	neutral	0.85	neutral	-0.66	0.09	neutral	0.24	0.45	0.24	neutral	0.18	neutral	0.33	neutral	0.24	neutral	5	0.95	neutral	0.38	neutral	-2	neutral	0.59	deleterious	-2.02	low_impact	0.43	medium_impact	-1.28	low_impact	0.36	0.8	16.05	26	0.27	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9013	9013	A	C	MI.1034	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	487	163	N	H	Aac/Cac	-13.06	0	0	probably_damaging	1	deleterious	0	neutral	1.76	deleterious	-10.16	deleterious	-4.49	high_impact	4.63	0.55	damaging	0.09	damaging	3.15	22.60	deleterious	0.18	0.65	0.98	disease	0.89	disease	0.84	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.45	0.9	49.56	8.85	0.42	N	0.98	disease_causing	0.63	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15689	15689	A	T	MI.10340	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	943	315	M	L	Ata/Tta	-1.21	0	0	probably_damaging	0.96	neutral	0.71	neutral	3.27	neutral	0.96	neutral	-0.22	neutral_impact	-0.1	0.94	neutral	0.85	neutral	-0.57	0.15	neutral	0.24	0.45	0.24	neutral	0.18	neutral	0.33	neutral	0.24	neutral	5	0.95	neutral	0.38	neutral	-2	neutral	0.59	deleterious	-2.02	low_impact	0.43	medium_impact	-1.28	low_impact	0.36	0.8	16.05	26	0.28	N	0.07	polymorphism	1	0.00	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15690	15690	T	C	MI.10341	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	944	315	M	T	aTa/aCa	-1.21	0	0	probably_damaging	1	neutral	0.44	neutral	3.13	neutral	-0.6	neutral	-2.3	low_impact	1.64	0.85	neutral	0.17	damaging	1.97	16.04	deleterious	0.19	0.45	0.35	neutral	0.53	disease	0.49	neutral	0.24	neutral	5	1	deleterious	0.22	neutral	-2	neutral	0.71	deleterious	-3.53	low_impact	0.17	medium_impact	0.3	medium_impact	0.11	0.8	16.05	26	0.26	N	0.85	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15690	15690	T	A	MI.10342	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	944	315	M	K	aTa/aAa	-1.21	0	0	probably_damaging	1	neutral	0.35	neutral	3.1	neutral	-1.32	deleterious	-2.71	medium_impact	3.01	0.85	neutral	0.12	damaging	3.98	23.60	deleterious	0.05	0.35	0.36	neutral	0.75	disease	0.65	disease	0.69	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	0.08	medium_impact	1.54	medium_impact	0.13	0.8	16.05	26	0.27	N	0.96	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15691	15691	A	T	MI.10343	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	945	315	M	I	atA/atT	2.69	0.07	0	probably_damaging	0.98	neutral	0.43	neutral	3.17	neutral	0.01	neutral	-1.02	low_impact	1.84	0.9	neutral	0.17	damaging	1.82	15.13	deleterious	0.26	0.45	0.29	neutral	0.6	disease	0.45	neutral	0.22	neutral	6	0.98	deleterious	0.23	neutral	-2	neutral	0.70	deleterious	-2.31	low_impact	0.16	medium_impact	0.48	medium_impact	0.48	0.8	16.05	26	0.4	N	0.66	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15691	15691	A	C	MI.10344	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	945	315	M	I	atA/atC	2.69	0.07	0	probably_damaging	0.98	neutral	0.43	neutral	3.17	neutral	0.01	neutral	-1.02	low_impact	1.84	0.9	neutral	0.17	damaging	1.77	14.80	neutral	0.26	0.45	0.29	neutral	0.6	disease	0.45	neutral	0.22	neutral	6	0.98	deleterious	0.23	neutral	-2	neutral	0.70	deleterious	-2.31	low_impact	0.16	medium_impact	0.48	medium_impact	0.48	0.8	16.05	26	0.4	N	0.66	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15692	15692	A	T	MI.10345	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	946	316	M	L	Ata/Tta	-1.44	0	0	benign	0.03	neutral	0.81	neutral	3.06	neutral	1.47	neutral	-0.57	medium_impact	2.36	0.97	neutral	0.79	neutral	0.49	7.34	deleterious	0.27	0.45	0.23	neutral	0.52	disease	0.64	disease	0.58	disease	2	0.13	neutral	0.89	deleterious	-3	neutral	0.14	neutral	0.68	medium_impact	0.56	medium_impact	0.95	medium_impact	0.49	0.8	20.53	21.18	0.3	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15692	15692	A	G	MI.10346	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	946	316	M	V	Ata/Gta	-1.44	0	0	benign	0.05	neutral	0.58	neutral	3.04	neutral	0.73	neutral	-0.36	low_impact	1.94	0.96	neutral	0.73	neutral	-0.20	1.08	neutral	0.26	0.45	0.2	neutral	0.55	disease	0.67	disease	0.43	neutral	1	0.36	neutral	0.77	deleterious	-6	neutral	0.13	neutral	0.46	medium_impact	0.3	medium_impact	0.57	medium_impact	0.41	0.8	20.53	21.18	0.22	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15692	15692	A	C	MI.10347	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	946	316	M	L	Ata/Cta	-1.44	0	0	benign	0.03	neutral	0.81	neutral	3.06	neutral	1.47	neutral	-0.57	medium_impact	2.36	0.97	neutral	0.79	neutral	0.42	6.77	deleterious	0.27	0.45	0.23	neutral	0.52	disease	0.64	disease	0.58	disease	2	0.13	neutral	0.89	deleterious	-3	neutral	0.14	neutral	0.68	medium_impact	0.56	medium_impact	0.95	medium_impact	0.49	0.8	20.53	21.18	0.3	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15693	15693	T	A	MI.10348	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	947	316	M	K	aTa/aAa	0.63	0	0.02	benign	0.1	neutral	0.33	neutral	3.09	neutral	1.77	neutral	-0.89	low_impact	1.73	0.92	neutral	0.5	neutral	2.41	18.87	deleterious	0.06	0.35	0.44	neutral	0.72	disease	0.69	disease	0.6	disease	2	0.62	neutral	0.62	deleterious	-6	neutral	0.27	neutral	0.16	medium_impact	0.06	medium_impact	0.38	medium_impact	0.23	0.8	20.53	21.18	0.28	N	0.85	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15693	15693	T	C	MI.10349	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	947	316	M	T	aTa/aCa	0.63	0	0.02	benign	0.01	neutral	0.58	neutral	3.06	neutral	1.27	neutral	1.04	neutral_impact	-0.42	0.99	neutral	0.96	neutral	-1.09	0.01	neutral	0.14	0.4	0.23	neutral	0.18	neutral	0.52	disease	0.25	neutral	5	0.41	neutral	0.79	deleterious	-6	neutral	0.08	neutral	1.13	medium_impact	0.3	medium_impact	-1.58	low_impact	0.17	0.8	20.53	21.18	0.36	N	0.03	polymorphism	1	0.00	rs200975632	.	.	.	.	breast tumor	COSM6716259	.	5.35	T15693C	Possibly LVNC cardiomyopathy-associated	+	-	Reported	1	N	P	N,P	neutral
chrM	9013	9013	A	G	MI.1035	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	487	163	N	D	Aac/Gac	-13.06	0	0	probably_damaging	0.99	deleterious	0	neutral	1.78	deleterious	-8.08	deleterious	-4.49	high_impact	4.63	0.56	damaging	0.06	damaging	3.95	23.60	deleterious	0.33	0.65	0.93	disease	0.88	disease	0.82	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.43	0.9	49.56	8.85	0.44	N	0.97	polymorphism	0.55	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15694	15694	A	C	MI.10350	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	948	316	M	I	atA/atC	-0.06	0	0	benign	0.1	neutral	0.48	neutral	3.03	neutral	0.31	neutral	-0.76	low_impact	1.22	0.95	neutral	0.82	neutral	0.25	5.16	deleterious	0.23	0.45	0.28	neutral	0.57	disease	0.66	disease	0.42	neutral	2	0.45	neutral	0.69	deleterious	-6	neutral	0.19	neutral	0.16	medium_impact	0.2	medium_impact	-0.09	medium_impact	0.54	0.8	20.53	21.18	0.29	N	0.47	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15694	15694	A	T	MI.10351	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	948	316	M	I	atA/atT	-0.06	0	0	benign	0.1	neutral	0.48	neutral	3.03	neutral	0.31	neutral	-0.76	low_impact	1.22	0.95	neutral	0.82	neutral	0.31	5.78	deleterious	0.23	0.45	0.28	neutral	0.57	disease	0.66	disease	0.42	neutral	2	0.45	neutral	0.69	deleterious	-6	neutral	0.19	neutral	0.16	medium_impact	0.2	medium_impact	-0.09	medium_impact	0.54	0.8	20.53	21.18	0.3	N	0.47	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15695	15695	T	C	MI.10352	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	949	317	F	L	Ttt/Ctt	-3.5	0	0	probably_damaging	1	neutral	0.71	neutral	2.9	neutral	-0.82	deleterious	-3.71	medium_impact	3.21	0.92	neutral	0.1	damaging	3.86	23.50	deleterious	0.16	0.45	0.45	neutral	0.67	disease	0.68	disease	0.55	disease	1	1	deleterious	0.36	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	0.43	medium_impact	1.72	medium_impact	0.73	0.85	53.95	8.67	0.23	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15695	15695	T	A	MI.10353	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	949	317	F	I	Ttt/Att	-3.5	0	0	probably_damaging	1	neutral	0.48	neutral	2.85	neutral	-1.41	deleterious	-3.72	high_impact	5	0.87	neutral	0.12	damaging	4.36	24.10	deleterious	0.11	0.4	0.63	disease	0.82	disease	0.62	disease	0.66	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.2	medium_impact	3.35	high_impact	0.36	0.8	53.95	8.67	0.64	P	0.97	polymorphism	1	0.09	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15695	15695	T	G	MI.10354	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	949	317	F	V	Ttt/Gtt	-3.5	0	0	probably_damaging	1	neutral	0.54	neutral	2.88	neutral	-1.06	deleterious	-4.34	high_impact	4.46	0.88	neutral	0.11	damaging	4.06	23.70	deleterious	0.06	0.35	0.6	disease	0.81	disease	0.71	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.26	medium_impact	2.86	high_impact	0.25	0.8	53.95	8.67	0.37	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15696	15696	T	C	MI.10355	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	950	317	F	S	tTt/tCt	4.52	1	0	probably_damaging	1	neutral	0.45	neutral	2.83	neutral	-1.91	deleterious	-4.99	high_impact	3.56	0.86	neutral	0.08	damaging	4.42	24.20	deleterious	0.03	0.35	0.7	disease	0.79	disease	0.69	disease	0.67	disease	3	1	deleterious	0.23	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.18	medium_impact	2.04	high_impact	0.16	0.8	53.95	8.67	0.42	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15696	15696	T	G	MI.10356	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	950	317	F	C	tTt/tGt	4.52	1	0	probably_damaging	1	neutral	0.17	neutral	2.78	deleterious	-3.71	deleterious	-4.99	high_impact	4.46	0.87	neutral	0.09	damaging	4.28	24.00	deleterious	0.04	0.35	0.88	disease	0.81	disease	0.72	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.15	medium_impact	2.86	high_impact	0.19	0.8	53.95	8.67	0.54	P	0.99	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15696	15696	T	A	MI.10357	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	950	317	F	Y	tTt/tAt	4.52	1	0	probably_damaging	1	neutral	1	neutral	3.01	neutral	0.04	neutral	-1.78	low_impact	1.54	0.88	neutral	0.11	damaging	4.16	23.80	deleterious	0.12	0.4	0.62	disease	0.64	disease	0.45	neutral	0.22	neutral	6	1	deleterious	0.5	deleterious	-2	neutral	0.79	deleterious	-3.53	low_impact	1.85	high_impact	0.21	medium_impact	0.62	0.8	53.95	8.67	0.36	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15697	15697	T	G	MI.10358	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	951	317	F	L	ttT/ttG	7.27	1	0.01	probably_damaging	1	neutral	0.71	neutral	2.9	neutral	-0.82	deleterious	-3.71	medium_impact	3.21	0.92	neutral	0.1	damaging	4.22	23.90	deleterious	0.16	0.45	0.45	neutral	0.67	disease	0.68	disease	0.55	disease	1	1	deleterious	0.36	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	0.43	medium_impact	1.72	medium_impact	0.73	0.85	53.95	8.67	0.52	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15697	15697	T	A	MI.10359	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	951	317	F	L	ttT/ttA	7.27	1	0.01	probably_damaging	1	neutral	0.71	neutral	2.9	neutral	-0.82	deleterious	-3.71	medium_impact	3.21	0.92	neutral	0.1	damaging	4.30	24.00	deleterious	0.16	0.45	0.45	neutral	0.67	disease	0.68	disease	0.55	disease	1	1	deleterious	0.36	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	0.43	medium_impact	1.72	medium_impact	0.73	0.85	53.95	8.67	0.53	N	0.92	polymorphism	1	0.04	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9014	9014	A	T	MI.1036	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	488	163	N	I	aAc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	1.76	deleterious	-10.49	deleterious	-8.09	high_impact	4.63	0.52	damaging	0.06	damaging	3.99	23.60	deleterious	0.18	0.65	0.98	disease	0.95	disease	0.77	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.35	0.9	49.56	8.85	0.48	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15698	15698	C	T	MI.10360	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	952	318	R	C	Cgc/Tgc	-0.52	0.1	0	probably_damaging	1	neutral	0.17	neutral	2.85	deleterious	-6.08	deleterious	-4.87	high_impact	4.52	0.86	neutral	0.04	damaging	5.07	25.30	deleterious	0.08	0.35	0.91	disease	0.79	disease	0.72	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.15	medium_impact	2.91	high_impact	0.81	0.85	57.63	8.5	0.46	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15698	15698	C	G	MI.10361	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	952	318	R	G	Cgc/Ggc	-0.52	0.1	0	probably_damaging	1	neutral	0.36	neutral	2.88	deleterious	-3.99	deleterious	-4.29	high_impact	4.72	0.84	neutral	0.11	damaging	4.04	23.70	deleterious	0.05	0.35	0.76	disease	0.66	disease	0.78	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.09	medium_impact	3.09	high_impact	0.31	0.8	57.63	8.5	0.69	P	0.99	polymorphism	1	0.13	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15698	15698	C	A	MI.10362	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	952	318	R	S	Cgc/Agc	-0.52	0.1	0	probably_damaging	1	neutral	0.41	neutral	2.92	neutral	-2.66	deleterious	-3.65	medium_impact	3.08	0.8	neutral	0.06	damaging	4.48	24.20	deleterious	0.06	0.35	0.63	disease	0.73	disease	0.69	disease	0.66	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.80	deleterious	-3.53	low_impact	0.14	medium_impact	1.6	medium_impact	0.35	0.8	57.63	8.5	0.26	N	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15699	15699	G	T	MI.10363	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	953	318	R	L	cGc/cTc	2.69	0.97	0	probably_damaging	1	neutral	0.77	neutral	2.94	deleterious	-3.73	deleterious	-4.25	high_impact	4.72	0.87	neutral	0.06	damaging	2.89	21.80	deleterious	0.06	0.35	0.69	disease	0.83	disease	0.67	disease	0.68	disease	4	1	deleterious	0.39	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.51	medium_impact	3.09	high_impact	0.17	0.8	57.63	8.5	0.62	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15699	15699	G	C	MI.10364	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	953	318	R	P	cGc/cCc	2.69	0.97	0	probably_damaging	1	neutral	0.25	neutral	2.87	deleterious	-4.52	deleterious	-4.29	high_impact	3.87	0.86	neutral	0.04	damaging	4.22	23.90	deleterious	0.03	0.35	0.81	disease	0.82	disease	0.78	disease	0.71	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.04	medium_impact	2.32	high_impact	0.20	0.8	57.63	8.5	0.69	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	G15699C	Muscle Weakness SNHL and Migraine	-	+	Reported	2	.	P	P	damaging
chrM	15699	15699	G	A	MI.10365	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	953	318	R	H	cGc/cAc	2.69	0.97	0	probably_damaging	1	neutral	0.47	neutral	2.89	deleterious	-3.69	deleterious	-2.96	high_impact	4.38	0.82	neutral	0.06	damaging	4.46	24.20	deleterious	0.14	0.4	0.76	disease	0.73	disease	0.5	neutral	0.49	neutral	0	1	deleterious	0.24	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.19	medium_impact	2.78	high_impact	0.81	0.85	57.63	8.5	0.43	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15701	15701	C	A	MI.10366	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	955	319	P	T	Cca/Aca	-6.02	0	0	probably_damaging	1	neutral	0.4	neutral	2.82	neutral	-2.79	deleterious	-5.04	high_impact	4.16	0.82	neutral	0.08	damaging	3.73	23.30	deleterious	0.06	0.35	0.47	neutral	0.72	disease	0.7	disease	0.66	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	0.13	medium_impact	2.58	high_impact	0.56	0.8	58.42	8.63	0.29	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15701	15701	C	T	MI.10367	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	955	319	P	S	Cca/Tca	-6.02	0	0	probably_damaging	1	neutral	0.4	neutral	2.8	deleterious	-3.05	deleterious	-5.04	high_impact	3.81	0.84	neutral	0.07	damaging	3.98	23.60	deleterious	0.06	0.35	0.43	neutral	0.71	disease	0.7	disease	0.65	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.13	medium_impact	2.27	high_impact	0.18	0.8	58.42	8.63	0.27	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15701	15701	C	G	MI.10368	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	955	319	P	A	Cca/Gca	-6.02	0	0	probably_damaging	1	neutral	0.5	neutral	2.82	neutral	-2.64	deleterious	-5.04	high_impact	4.3	0.87	neutral	0.11	damaging	2.90	21.80	deleterious	0.07	0.35	0.41	neutral	0.58	disease	0.72	disease	0.66	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	0.22	medium_impact	2.71	high_impact	0.64	0.8	58.42	8.63	0.37	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15702	15702	C	A	MI.10369	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	956	319	P	Q	cCa/cAa	5.44	1	0	probably_damaging	1	neutral	0.3	neutral	2.78	deleterious	-3.68	deleterious	-5.05	high_impact	4.85	0.85	neutral	0.05	damaging	4.14	23.80	deleterious	0.05	0.35	0.46	neutral	0.79	disease	0.72	disease	0.67	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.02	medium_impact	3.21	high_impact	0.31	0.8	58.42	8.63	0.66	P	0.86	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9014	9014	A	C	MI.1037	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	488	163	N	T	aAc/aCc	8.69	1	0	probably_damaging	0.99	deleterious	0.04	neutral	1.77	deleterious	-8.96	deleterious	-5.35	high_impact	4.63	0.53	damaging	0.06	damaging	3.49	23.10	deleterious	0.21	0.65	0.84	disease	0.88	disease	0.77	disease	0.81	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-0.49	medium_impact	2.87	high_impact	0.45	0.9	49.56	8.85	0.51	P	0.96	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15702	15702	C	G	MI.10370	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	956	319	P	R	cCa/cGa	5.44	1	0	probably_damaging	1	neutral	0.38	neutral	2.81	neutral	-2.98	deleterious	-5.68	high_impact	4.85	0.82	neutral	0.05	damaging	3.67	23.20	deleterious	0.02	0.35	0.47	neutral	0.82	disease	0.75	disease	0.69	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.11	medium_impact	3.21	high_impact	0.27	0.8	58.42	8.63	0.68	P	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15702	15702	C	T	MI.10371	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	956	319	P	L	cCa/cTa	5.44	1	0	probably_damaging	1	neutral	0.66	neutral	2.88	neutral	-1.82	deleterious	-6.31	medium_impact	3.44	0.85	neutral	0.05	damaging	4.47	24.20	deleterious	0.04	0.35	0.49	neutral	0.78	disease	0.67	disease	0.65	disease	3	1	deleterious	0.33	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	0.38	medium_impact	1.93	medium_impact	0.53	0.8	58.42	8.63	0.38	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15704	15704	C	G	MI.10372	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	958	320	L	V	Cta/Gta	-14.04	0	0	probably_damaging	0.98	neutral	0.5	neutral	2.92	neutral	-0.52	neutral	-0.86	low_impact	1.64	0.97	neutral	0.73	neutral	0.79	9.38	deleterious	0.31	0.45	0.35	neutral	0.43	neutral	0.33	neutral	0.47	neutral	1	0.98	neutral	0.26	neutral	-2	neutral	0.66	deleterious	-2.31	low_impact	0.22	medium_impact	0.3	medium_impact	0.65	0.8	10	16.86	0.36	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15704	15704	C	A	MI.10373	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	958	320	L	M	Cta/Ata	-14.04	0	0	probably_damaging	1	neutral	0.22	neutral	2.89	neutral	-2.02	neutral	-0.65	low_impact	1.17	0.93	neutral	0.76	neutral	2.58	20.10	deleterious	0.33	0.5	0.58	disease	0.33	neutral	0.29	neutral	0.6	disease	2	1	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-3.53	low_impact	-0.08	medium_impact	-0.13	medium_impact	0.59	0.8	10	16.86	0.47	N	0.49	polymorphism	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15705	15705	T	A	MI.10374	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	959	320	L	Q	cTa/cAa	-9.69	0	0	probably_damaging	1	neutral	0.29	neutral	2.8	deleterious	-3.3	deleterious	-3.04	high_impact	3.52	0.94	neutral	0.52	neutral	4.24	23.90	deleterious	0.02	0.35	0.73	disease	0.71	disease	0.63	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.01	medium_impact	2	high_impact	0.24	0.8	10	16.86	0.37	N	0.91	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15705	15705	T	G	MI.10375	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	959	320	L	R	cTa/cGa	-9.69	0	0	probably_damaging	1	neutral	0.35	neutral	2.8	deleterious	-3.13	deleterious	-3.13	high_impact	4.32	0.94	neutral	0.47	neutral	4.22	23.90	deleterious	0.01	0.35	0.71	disease	0.85	disease	0.75	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.08	medium_impact	2.73	high_impact	0.16	0.8	10	16.86	0.51	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15705	15705	T	C	MI.10376	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	959	320	L	P	cTa/cCa	-9.69	0	0	probably_damaging	1	neutral	0.21	neutral	2.79	deleterious	-3.82	deleterious	-3.51	medium_impact	3.08	0.93	neutral	0.35	neutral	4.02	23.60	deleterious	0.01	0.35	0.79	disease	0.85	disease	0.69	disease	0.7	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.87	deleterious	-3.53	low_impact	-0.09	medium_impact	1.6	medium_impact	0.18	0.8	10	16.86	0.38	N	0.94	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15707	15707	A	G	MI.10377	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	961	321	S	G	Agc/Ggc	-20	0	0	probably_damaging	1	neutral	0.36	neutral	2.94	neutral	-1.85	neutral	-2.15	medium_impact	2.45	0.97	neutral	0.52	neutral	3.40	23.00	deleterious	0.12	0.4	0.46	neutral	0.6	disease	0.34	neutral	0.32	neutral	4	1	deleterious	0.18	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	0.09	medium_impact	1.03	medium_impact	0.62	0.8	17.63	26.07	0.34	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15707	15707	A	T	MI.10378	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	961	321	S	C	Agc/Tgc	-20	0	0	probably_damaging	1	neutral	0.17	neutral	2.92	deleterious	-3.11	neutral	-2.33	medium_impact	3.35	0.95	neutral	0.35	neutral	3.53	23.10	deleterious	0.06	0.35	0.78	disease	0.79	disease	0.52	disease	0.64	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.78	deleterious	-3.53	low_impact	-0.15	medium_impact	1.85	medium_impact	0.36	0.8	17.63	26.07	0.36	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15707	15707	A	C	MI.10379	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	961	321	S	R	Agc/Cgc	-20	0	0	probably_damaging	1	neutral	0.36	neutral	2.93	neutral	-1.56	neutral	-2.26	high_impact	3.64	0.95	neutral	0.4	neutral	3.95	23.60	deleterious	0.03	0.35	0.46	neutral	0.87	disease	0.75	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.09	medium_impact	2.11	high_impact	0.47	0.8	17.63	26.07	0.41	N	0.95	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9014	9014	A	G	MI.1038	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	488	163	N	S	aAc/aGc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	1.78	deleterious	-8.41	deleterious	-4.45	high_impact	4.63	0.5	damaging	0.06	damaging	3.20	22.70	deleterious	0.29	0.65	0.92	disease	0.88	disease	0.76	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.37	0.9	49.56	8.85	0.52	P	0.91	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15708	15708	G	T	MI.10380	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	962	321	S	I	aGc/aTc	1.54	0.77	0	probably_damaging	1	neutral	0.58	neutral	3.01	neutral	-0.81	deleterious	-2.68	medium_impact	3.35	0.95	neutral	0.44	neutral	4.22	23.90	deleterious	0.03	0.35	0.49	neutral	0.89	disease	0.62	disease	0.69	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.3	medium_impact	1.85	medium_impact	0.37	0.8	17.63	26.07	0.25	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15708	15708	G	A	MI.10381	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	962	321	S	N	aGc/aAc	1.54	0.77	0	probably_damaging	0.99	neutral	0.33	neutral	2.94	neutral	-1.71	neutral	-1.2	low_impact	1.5	0.94	neutral	0.47	neutral	2.20	17.54	deleterious	0.35	0.5	0.36	neutral	0.69	disease	0.26	neutral	0.19	neutral	6	0.99	deleterious	0.17	neutral	-2	neutral	0.72	deleterious	-2.59	low_impact	0.06	medium_impact	0.17	medium_impact	0.49	0.8	17.63	26.07	0.33	N	0.59	polymorphism	1	0.01	.	not_provided	not_provided	434776	MedGen:CN517202	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15708	15708	G	C	MI.10382	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	962	321	S	T	aGc/aCc	1.54	0.77	0	probably_damaging	0.99	neutral	0.55	neutral	2.98	neutral	-0.95	neutral	-0.07	neutral_impact	0.78	0.98	neutral	0.93	neutral	0.21	4.82	deleterious	0.2	0.45	0.3	neutral	0.17	neutral	0.29	neutral	0.26	neutral	5	0.99	deleterious	0.28	neutral	-2	neutral	0.65	deleterious	-2.59	low_impact	0.27	medium_impact	-0.49	medium_impact	0.62	0.8	17.63	26.07	0.33	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15710	15710	C	A	MI.10383	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	964	322	Q	K	Caa/Aaa	-6.71	0	0	benign	0.41	neutral	0.29	neutral	3.14	neutral	1.03	neutral	-2.43	low_impact	1.27	0.9	neutral	0.11	damaging	2.33	18.35	deleterious	0.18	0.45	0.2	neutral	0.73	disease	0.37	neutral	0.18	neutral	6	0.66	neutral	0.44	neutral	-6	neutral	0.52	deleterious	-0.58	medium_impact	0.01	medium_impact	-0.04	medium_impact	0.40	0.8	58.42	8.35	0.29	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15710	15710	C	G	MI.10384	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	964	322	Q	E	Caa/Gaa	-6.71	0	0	benign	0.3	neutral	0.28	neutral	2.98	neutral	-0.21	neutral	-1.85	high_impact	4.07	0.83	neutral	0.12	damaging	1.51	13.38	neutral	0.33	0.5	0.29	neutral	0.66	disease	0.68	disease	0.65	disease	3	0.66	neutral	0.49	deleterious	-2	neutral	0.40	neutral	-0.39	medium_impact	0	medium_impact	2.5	high_impact	0.39	0.8	58.42	8.35	0.35	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15711	15711	A	G	MI.10385	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	965	322	Q	R	cAa/cGa	5.44	1	0	possibly_damaging	0.52	neutral	0.35	neutral	2.97	neutral	-0.37	neutral	-2.45	medium_impact	2.42	0.91	neutral	0.11	damaging	3.19	22.70	deleterious	0.17	0.45	0.4	neutral	0.8	disease	0.5	neutral	0.39	neutral	2	0.63	neutral	0.42	neutral	0	NA	0.58	deleterious	-0.76	medium_impact	0.08	medium_impact	1	medium_impact	0.15	0.8	58.42	8.35	0.45	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15711	15711	A	T	MI.10386	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	965	322	Q	L	cAa/cTa	5.44	1	0	possibly_damaging	0.61	neutral	0.65	neutral	2.91	neutral	-1.27	deleterious	-4.35	medium_impact	3.33	0.86	neutral	0.09	damaging	2.35	18.48	deleterious	0.05	0.35	0.54	disease	0.84	disease	0.64	disease	0.67	disease	3	0.54	neutral	0.52	deleterious	0	NA	0.64	deleterious	-0.91	medium_impact	0.37	medium_impact	1.83	medium_impact	0.11	0.8	58.42	8.35	0.42	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15711	15711	A	C	MI.10387	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	965	322	Q	P	cAa/cCa	5.44	1	0	probably_damaging	0.92	neutral	0.21	neutral	2.89	neutral	-2.15	deleterious	-3.73	high_impact	4.18	0.83	neutral	0.07	damaging	3.33	22.90	deleterious	0.03	0.35	0.64	disease	0.84	disease	0.78	disease	0.69	disease	4	0.95	neutral	0.15	neutral	2	deleterious	0.79	deleterious	-1.72	low_impact	-0.09	medium_impact	2.6	high_impact	0.20	0.8	58.42	8.35	0.56	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15712	15712	A	C	MI.10388	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	966	322	Q	H	caA/caC	8.42	1	0	benign	0.03	neutral	0.54	neutral	2.89	neutral	-2.11	deleterious	-3.1	high_impact	4.53	0.8	neutral	0.12	damaging	3.40	23.00	deleterious	0.18	0.45	0.6	disease	0.75	disease	0.7	disease	0.68	disease	4	0.42	neutral	0.76	deleterious	-2	neutral	0.27	neutral	0.68	medium_impact	0.26	medium_impact	2.92	high_impact	0.51	0.8	58.42	8.35	0.51	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15712	15712	A	T	MI.10389	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	966	322	Q	H	caA/caT	8.42	1	0	benign	0.03	neutral	0.54	neutral	2.89	neutral	-2.11	deleterious	-3.1	high_impact	4.53	0.8	neutral	0.12	damaging	3.56	23.10	deleterious	0.18	0.45	0.6	disease	0.75	disease	0.7	disease	0.68	disease	4	0.42	neutral	0.76	deleterious	-2	neutral	0.27	neutral	0.68	medium_impact	0.26	medium_impact	2.92	high_impact	0.51	0.8	58.42	8.35	0.51	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9015	9015	C	A	MI.1039	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	489	163	N	K	aaC/aaA	7.07	1	0	probably_damaging	0.99	deleterious	0	neutral	1.77	deleterious	-8.84	deleterious	-5.39	high_impact	4.63	0.53	damaging	0.05	damaging	4.58	24.40	deleterious	0.24	0.65	0.96	disease	0.93	disease	0.82	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.58	0.9	49.56	8.85	0.52	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15713	15713	T	A	MI.10390	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	967	323	S	T	Tca/Aca	1.54	0.78	0	benign	0.15	neutral	0.39	neutral	3.02	neutral	0.4	neutral	0.31	neutral_impact	-0.99	0.96	neutral	0.96	neutral	0.61	8.22	deleterious	0.32	0.5	0.21	neutral	0.13	neutral	0.25	neutral	0.28	neutral	4	0.54	neutral	0.62	deleterious	-6	neutral	0.10	neutral	-0.03	medium_impact	0.12	medium_impact	-2.09	low_impact	0.70	0.85	29.21	40.21	0.38	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15713	15713	T	C	MI.10391	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	967	323	S	P	Tca/Cca	1.54	0.78	0	possibly_damaging	0.45	neutral	0.2	neutral	2.95	neutral	-1.6	neutral	-1.04	low_impact	0.83	0.84	neutral	0.44	neutral	3.82	23.40	deleterious	0.08	0.35	0.33	neutral	0.77	disease	0.53	disease	0.6	disease	2	0.77	neutral	0.38	neutral	-3	neutral	0.37	neutral	-0.65	medium_impact	-0.1	medium_impact	-0.44	medium_impact	0.45	0.8	29.21	40.21	0.28	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15713	15713	T	G	MI.10392	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	967	323	S	A	Tca/Gca	1.54	0.78	0	benign	0.05	neutral	0.51	neutral	3.08	neutral	1.15	neutral	0.25	neutral_impact	-0.52	0.87	neutral	0.83	neutral	0.89	10.04	neutral	0.32	0.5	0.21	neutral	0.22	neutral	0.37	neutral	0.35	neutral	3	0.44	neutral	0.73	deleterious	-6	neutral	0.11	neutral	0.46	medium_impact	0.23	medium_impact	-1.67	low_impact	0.60	0.8	29.21	40.21	0.32	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15714	15714	C	G	MI.10393	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	968	323	S	W	tCa/tGa	-1.44	0	0	possibly_damaging	0.76	neutral	0.18	neutral	2.98	neutral	-0.41	neutral	-0.21	neutral_impact	0.72	0.85	neutral	0.48	neutral	4.31	24.00	deleterious	0.06	0.35	0.37	neutral	0.71	disease	0.38	neutral	0.4	neutral	2	0.87	neutral	0.21	neutral	-3	neutral	0.47	deleterious	-1.2	low_impact	-0.14	medium_impact	-0.54	medium_impact	0.17	0.8	29.21	40.21	0.32	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15714	15714	C	T	MI.10394	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	968	323	S	L	tCa/tTa	-1.44	0	0	benign	0	neutral	0.65	neutral	3.14	neutral	1.64	neutral	1.31	neutral_impact	-1.58	0.96	neutral	0.85	neutral	2.84	21.60	deleterious	0.09	0.35	0.16	neutral	0.31	neutral	0.26	neutral	0.43	neutral	1	0.35	neutral	0.83	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.37	medium_impact	-2.63	low_impact	0.52	0.8	29.21	40.21	0.31	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15716	15716	C	G	MI.10395	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	970	324	L	V	Ctt/Gtt	-5.33	0	0	benign	0.08	neutral	0.46	neutral	2.91	neutral	-0.64	neutral	-1.35	medium_impact	2.29	0.98	neutral	0.78	neutral	3.18	22.70	deleterious	0.31	0.45	0.46	neutral	0.45	neutral	0.42	neutral	0.42	neutral	2	0.48	neutral	0.69	deleterious	-3	neutral	0.19	neutral	0.26	medium_impact	0.18	medium_impact	0.89	medium_impact	0.61	0.8	42.63	9.99	0.33	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15716	15716	C	A	MI.10396	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	970	324	L	I	Ctt/Att	-5.33	0	0	benign	0.28	neutral	0.5	neutral	2.88	neutral	-0.55	neutral	-0.92	medium_impact	2.07	0.95	neutral	0.74	neutral	2.98	22.20	deleterious	0.35	0.5	0.39	neutral	0.51	disease	0.39	neutral	0.19	neutral	6	0.4	neutral	0.61	deleterious	-3	neutral	0.23	neutral	-0.35	medium_impact	0.22	medium_impact	0.69	medium_impact	0.65	0.8	42.63	9.99	0.32	N	0.51	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15716	15716	C	T	MI.10397	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	970	324	L	F	Ctt/Ttt	-5.33	0	0	possibly_damaging	0.52	neutral	0.67	neutral	2.85	neutral	-1.26	neutral	-1.99	low_impact	1.75	0.97	neutral	0.54	neutral	3.98	23.60	deleterious	0.18	0.45	0.47	neutral	0.55	disease	0.43	neutral	0.17	neutral	7	0.44	neutral	0.58	deleterious	-3	neutral	0.46	deleterious	-0.76	medium_impact	0.39	medium_impact	0.4	medium_impact	0.66	0.8	42.63	9.99	0.22	N	0.92	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15717	15717	T	A	MI.10398	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	971	324	L	H	cTt/cAt	-4.19	0	0	probably_damaging	0.93	neutral	0.23	neutral	2.77	deleterious	-3.77	deleterious	-3.66	high_impact	4.72	0.93	neutral	0.41	neutral	4.41	24.10	deleterious	0.04	0.35	0.91	disease	0.76	disease	0.69	disease	0.66	disease	3	0.95	neutral	0.15	neutral	2	deleterious	0.78	deleterious	-1.78	low_impact	-0.06	medium_impact	3.09	high_impact	0.29	0.8	42.63	9.99	0.66	P	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15717	15717	T	G	MI.10399	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	971	324	L	R	cTt/cGt	-4.19	0	0	possibly_damaging	0.68	neutral	0.18	neutral	2.79	deleterious	-3.06	deleterious	-3.1	high_impact	4.72	0.94	neutral	0.39	neutral	4.24	23.90	deleterious	0.01	0.35	0.88	disease	0.86	disease	0.72	disease	0.64	disease	3	0.85	neutral	0.25	neutral	1	deleterious	0.66	deleterious	-1.04	low_impact	-0.14	medium_impact	3.09	high_impact	0.23	0.8	42.63	9.99	0.69	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8573	8573	G	T	MI.104	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	47	16	G	V	gGc/gTc	6.14	1	0	probably_damaging	0.93	neutral	0.08	neutral	4.63	neutral	-0.22	deleterious	-7.22	high_impact	3.67	0.75	neutral	0.29	neutral	3.47	23.00	deleterious	0.22	0.65	0.43	neutral	0.91	disease	0.68	disease	0.76	disease	5	0.98	neutral	0.08	neutral	2	deleterious	0.77	deleterious	-1.82	low_impact	-0.31	medium_impact	2.05	high_impact	0.71	0.9	17.26	11.64	0.54	P	0.97	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9015	9015	C	G	MI.1040	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	489	163	N	K	aaC/aaG	7.07	1	0	probably_damaging	0.99	deleterious	0	neutral	1.77	deleterious	-8.84	deleterious	-5.39	high_impact	4.63	0.53	damaging	0.05	damaging	4.05	23.70	deleterious	0.24	0.65	0.96	disease	0.93	disease	0.82	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.58	0.9	49.56	8.85	0.52	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15717	15717	T	C	MI.10400	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	971	324	L	P	cTt/cCt	-4.19	0	0	possibly_damaging	0.83	neutral	0.18	neutral	2.77	deleterious	-3.84	deleterious	-3.65	high_impact	4.38	0.93	neutral	0.32	neutral	4.03	23.60	deleterious	0.01	0.35	0.91	disease	0.81	disease	0.72	disease	0.64	disease	3	0.91	neutral	0.18	neutral	1	deleterious	0.77	deleterious	-1.37	low_impact	-0.14	medium_impact	2.78	high_impact	0.34	0.8	42.63	9.99	0.5	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15719	15719	T	C	MI.10401	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	973	325	Y	H	Tat/Cat	-0.29	0.36	0	benign	0.03	neutral	0.32	neutral	3.11	neutral	-1.62	neutral	-2.49	medium_impact	3.21	0.89	neutral	0.49	neutral	1.98	16.11	deleterious	0.14	0.4	0.61	disease	0.63	disease	0.72	disease	0.72	disease	4	0.66	neutral	0.65	deleterious	-3	neutral	0.24	neutral	0.68	medium_impact	0.05	medium_impact	1.72	medium_impact	0.31	0.8	22.37	28.64	0.31	N	0.70	polymorphism	1	0.05	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15719	15719	T	G	MI.10402	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	973	325	Y	D	Tat/Gat	-0.29	0.36	0	possibly_damaging	0.73	neutral	0.12	neutral	3.11	neutral	-1.81	deleterious	-3.91	medium_impact	3.21	0.9	neutral	0.4	neutral	2.39	18.78	deleterious	0.03	0.35	0.67	disease	0.85	disease	0.72	disease	0.75	disease	5	0.91	neutral	0.2	neutral	0	NA	0.76	deleterious	-1.13	low_impact	-0.25	medium_impact	1.72	medium_impact	0.23	0.8	22.37	28.64	0.39	N	0.86	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15719	15719	T	A	MI.10403	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	973	325	Y	N	Tat/Aat	-0.29	0.36	0	possibly_damaging	0.66	neutral	0.42	neutral	3.13	neutral	-0.93	deleterious	-3.82	medium_impact	1.97	0.92	neutral	0.59	neutral	2.47	19.27	deleterious	0.05	0.35	0.56	disease	0.83	disease	0.62	disease	0.75	disease	5	0.67	neutral	0.38	neutral	0	NA	0.61	deleterious	-1	medium_impact	0.15	medium_impact	0.6	medium_impact	0.28	0.8	22.37	28.64	0.29	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15720	15720	A	G	MI.10404	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	974	325	Y	C	tAt/tGt	4.52	1	0	probably_damaging	0.96	neutral	0.11	neutral	3.1	neutral	-2.36	deleterious	-3.26	medium_impact	3.21	0.95	neutral	0.4	neutral	2.04	16.44	deleterious	0.04	0.35	0.6	disease	0.79	disease	0.67	disease	0.74	disease	5	0.98	deleterious	0.08	neutral	1	deleterious	0.76	deleterious	-2.02	low_impact	-0.27	medium_impact	1.72	medium_impact	0.21	0.8	22.37	28.64	0.45	N	0.67	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15720	15720	A	C	MI.10405	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	974	325	Y	S	tAt/tCt	4.52	1	0	possibly_damaging	0.73	neutral	0.34	neutral	3.14	neutral	-0.58	deleterious	-3.27	low_impact	1.76	0.92	neutral	0.54	neutral	2.20	17.49	deleterious	0.05	0.35	0.38	neutral	0.68	disease	0.62	disease	0.7	disease	4	0.77	neutral	0.31	neutral	-3	neutral	0.61	deleterious	-1.13	low_impact	0.07	medium_impact	0.41	medium_impact	0.24	0.8	22.37	28.64	0.49	N	0.72	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15720	15720	A	T	MI.10406	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	974	325	Y	F	tAt/tTt	4.52	1	0	possibly_damaging	0.57	neutral	1	neutral	3.45	neutral	2.21	neutral	1.31	neutral_impact	-1.86	0.96	neutral	0.95	neutral	-0.88	0.03	neutral	0.22	0.45	0.22	neutral	0.13	neutral	0.4	neutral	0.22	neutral	6	0.57	neutral	0.72	deleterious	-3	neutral	0.49	deleterious	-0.85	medium_impact	1.85	high_impact	-2.88	low_impact	0.49	0.8	22.37	28.64	0.46	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15722	15722	T	C	MI.10407	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	976	326	W	R	Tga/Cga	-0.29	0.7	0	probably_damaging	1	neutral	0.13	neutral	2.94	neutral	-2.62	deleterious	-8.62	high_impact	4.59	0.81	neutral	0.07	damaging	2.06	16.60	deleterious	0.03	0.35	0.75	disease	0.89	disease	0.82	disease	0.76	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.23	medium_impact	2.97	high_impact	0.14	0.8	57.89	8.47	0.52	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15722	15722	T	G	MI.10408	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	976	326	W	G	Tga/Gga	-0.29	0.7	0	probably_damaging	1	neutral	0.2	neutral	2.96	neutral	-2.17	deleterious	-8	high_impact	3.62	0.75	neutral	0.13	damaging	2.35	18.49	deleterious	0.04	0.35	0.73	disease	0.81	disease	0.77	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.1	medium_impact	2.09	high_impact	0.15	0.8	57.89	8.47	0.37	N	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15723	15723	G	C	MI.10409	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	977	326	W	S	tGa/tCa	5.67	1	0	probably_damaging	1	neutral	0.32	neutral	2.95	neutral	-2.27	deleterious	-8.62	high_impact	4.11	0.74	neutral	0.1	damaging	2.44	19.11	deleterious	0.04	0.35	0.63	disease	0.86	disease	0.77	disease	0.73	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.05	medium_impact	2.54	high_impact	0.13	0.8	57.89	8.47	0.57	P	0.99	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9016	9016	A	T	MI.1041	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	490	164	I	F	Att/Ttt	-3.34	0	0	probably_damaging	0.99	deleterious	0	neutral	3.5	deleterious	-3.76	deleterious	-2.96	medium_impact	3	0.83	neutral	0.43	neutral	3.59	23.20	deleterious	0.26	0.65	0.62	disease	0.74	disease	0.67	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-2.65	low_impact	-1.4	low_impact	1.47	medium_impact	0.74	0.9	48.67	8.91	0.31	N	0.97	polymorphism	0.6	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15723	15723	G	T	MI.10410	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	977	326	W	L	tGa/tTa	5.67	1	0	probably_damaging	1	neutral	0.87	neutral	3.08	neutral	-0.63	deleterious	-8	medium_impact	3.46	0.75	neutral	0.08	damaging	2.69	20.70	deleterious	0.05	0.35	0.36	neutral	0.85	disease	0.75	disease	0.72	disease	4	1	deleterious	0.44	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	0.67	medium_impact	1.95	medium_impact	0.11	0.8	57.89	8.47	0.45	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15724	15724	A	C	MI.10411	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	978	326	W	C	tgA/tgC	7.27	1	0.02	probably_damaging	1	neutral	0.08	neutral	2.91	deleterious	-4.01	deleterious	-8	high_impact	4.59	0.77	neutral	0.05	damaging	2.46	19.22	deleterious	0.04	0.35	0.8	disease	0.85	disease	0.79	disease	0.72	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.35	medium_impact	2.97	high_impact	0.16	0.8	57.89	8.47	0.54	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15724	15724	A	T	MI.10412	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	978	326	W	C	tgA/tgT	7.27	1	0.02	probably_damaging	1	neutral	0.08	neutral	2.91	deleterious	-4.01	deleterious	-8	high_impact	4.59	0.77	neutral	0.05	damaging	2.57	19.93	deleterious	0.04	0.35	0.8	disease	0.85	disease	0.79	disease	0.72	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.35	medium_impact	2.97	high_impact	0.16	0.8	57.89	8.47	0.54	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15725	15725	C	T	MI.10413	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	979	327	L	F	Ctc/Ttc	4.52	0.99	0	benign	0.03	neutral	0.97	neutral	2.86	neutral	-1.77	neutral	-0.93	low_impact	1.26	0.93	neutral	0.9	neutral	1.39	12.72	neutral	0.25	0.45	0.52	disease	0.33	neutral	0.29	neutral	0.37	neutral	3	0	neutral	0.97	deleterious	-6	neutral	0.15	neutral	0.68	medium_impact	1.04	medium_impact	-0.05	medium_impact	0.59	0.8	16.58	16.73	0.43	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15725	15725	C	G	MI.10414	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	979	327	L	V	Ctc/Gtc	4.52	0.99	0	benign	0.17	neutral	0.57	neutral	2.96	neutral	-0.76	neutral	-0.14	low_impact	1.51	0.96	neutral	0.93	neutral	0.43	6.90	deleterious	0.31	0.45	0.33	neutral	0.19	neutral	0.28	neutral	0.38	neutral	3	0.32	neutral	0.7	deleterious	-6	neutral	0.13	neutral	-0.09	medium_impact	0.29	medium_impact	0.18	medium_impact	0.66	0.8	16.58	16.73	0.5	N	0.40	polymorphism	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15725	15725	C	A	MI.10415	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	979	327	L	I	Ctc/Atc	4.52	0.99	0	benign	0.36	neutral	0.77	neutral	2.97	neutral	-0.59	neutral	-0.21	neutral_impact	0.47	0.95	neutral	0.95	neutral	0.24	5.10	deleterious	0.31	0.45	0.22	neutral	0.12	neutral	0.22	neutral	0.28	neutral	4	0.25	neutral	0.71	deleterious	-6	neutral	0.15	neutral	-0.5	medium_impact	0.51	medium_impact	-0.77	medium_impact	0.61	0.8	16.58	16.73	0.47	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15726	15726	T	A	MI.10416	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	980	327	L	H	cTc/cAc	-5.79	0	0	probably_damaging	0.95	neutral	0.47	neutral	2.78	deleterious	-4.13	neutral	-1.85	high_impact	3.6	0.82	neutral	0.49	neutral	2.80	21.30	deleterious	0.06	0.35	0.72	disease	0.53	disease	0.54	disease	0.62	disease	2	0.95	neutral	0.26	neutral	2	deleterious	0.69	deleterious	-1.92	low_impact	0.19	medium_impact	2.08	high_impact	0.21	0.8	16.58	16.73	0.32	N	0.71	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15726	15726	T	C	MI.10417	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	980	327	L	P	cTc/cCc	-5.79	0	0	probably_damaging	0.97	neutral	0.18	neutral	2.78	deleterious	-4.12	neutral	-1.65	high_impact	3.6	0.83	neutral	0.38	neutral	2.41	18.86	deleterious	0.04	0.35	0.72	disease	0.78	disease	0.6	disease	0.69	disease	4	0.98	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-2.14	low_impact	-0.14	medium_impact	2.08	high_impact	0.29	0.8	16.58	16.73	0.3	N	0.94	polymorphism	1	0.09	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15726	15726	T	G	MI.10418	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	980	327	L	R	cTc/cGc	-5.79	0	0	probably_damaging	0.9	neutral	0.3	neutral	2.79	deleterious	-3.55	neutral	-1.46	high_impact	3.94	0.84	neutral	0.49	neutral	2.69	20.70	deleterious	0.04	0.35	0.64	disease	0.7	disease	0.6	disease	0.67	disease	3	0.92	neutral	0.2	neutral	2	deleterious	0.68	deleterious	-1.62	low_impact	0.02	medium_impact	2.38	high_impact	0.20	0.8	16.58	16.73	0.38	N	0.81	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15728	15728	C	A	MI.10419	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	982	328	L	M	Cta/Ata	-14.73	0	0	probably_damaging	0.97	neutral	0.39	neutral	2.77	neutral	-2.31	neutral	-0.83	medium_impact	2.21	0.87	neutral	0.1	damaging	2.20	17.53	deleterious	0.19	0.45	0.52	disease	0.36	neutral	0.41	neutral	0.3	neutral	4	0.97	neutral	0.21	neutral	1	deleterious	0.68	deleterious	-2.14	low_impact	0.12	medium_impact	0.81	medium_impact	0.59	0.8	55.26	8.58	0.32	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9016	9016	A	C	MI.1042	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	490	164	I	L	Att/Ctt	-3.34	0	0	probably_damaging	0.93	neutral	1	neutral	3.86	neutral	-1.54	neutral	-0.53	neutral_impact	-0.9	0.71	neutral	0.66	neutral	0.89	9.99	deleterious	0.38	0.65	0.44	neutral	0.16	neutral	0.27	neutral	0.25	neutral	5	0.93	neutral	0.54	deleterious	-2	neutral	0.63	deleterious	-1.82	low_impact	1.98	high_impact	-1.87	low_impact	0.71	0.9	48.67	8.91	0.25	N	0.83	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15728	15728	C	G	MI.10420	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	982	328	L	V	Cta/Gta	-14.73	0	0	possibly_damaging	0.49	neutral	0.39	neutral	2.82	neutral	-1.51	neutral	-1.52	high_impact	3.73	0.91	neutral	0.11	damaging	1.88	15.46	deleterious	0.21	0.45	0.39	neutral	0.39	neutral	0.63	disease	0.45	neutral	1	0.59	neutral	0.45	neutral	1	deleterious	0.48	deleterious	-0.72	medium_impact	0.12	medium_impact	2.19	high_impact	0.44	0.8	55.26	8.58	0.34	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15729	15729	T	A	MI.10421	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	983	328	L	Q	cTa/cAa	-0.98	0	0	probably_damaging	1	neutral	0.19	neutral	2.74	deleterious	-3.39	deleterious	-3.25	high_impact	4.42	0.86	neutral	0.07	damaging	2.53	19.66	deleterious	0.04	0.35	0.69	disease	0.67	disease	0.63	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	-0.12	medium_impact	2.82	high_impact	0.35	0.8	55.26	8.58	0.39	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15729	15729	T	C	MI.10422	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	983	328	L	P	cTa/cCa	-0.98	0	0	probably_damaging	1	neutral	0.15	neutral	2.72	deleterious	-4.32	deleterious	-3.88	high_impact	4.76	0.87	neutral	0.05	damaging	2.37	18.60	deleterious	0.03	0.35	0.76	disease	0.74	disease	0.74	disease	0.71	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.19	medium_impact	3.13	high_impact	0.32	0.8	55.26	8.58	0.66	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15729	15729	T	G	MI.10423	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	983	328	L	R	cTa/cGa	-0.98	0	0	probably_damaging	1	neutral	0.19	neutral	2.73	deleterious	-3.68	deleterious	-3.31	high_impact	4.76	0.87	neutral	0.06	damaging	2.63	20.40	deleterious	0.03	0.35	0.67	disease	0.79	disease	0.74	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.12	medium_impact	3.13	high_impact	0.22	0.8	55.26	8.58	0.67	P	0.99	polymorphism	1	0.19	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15731	15731	G	A	MI.10424	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	985	329	A	T	Gcc/Acc	-0.29	0	0	benign	0.01	neutral	0.31	neutral	2.97	neutral	-0.47	neutral	0.06	neutral_impact	0.22	0.99	neutral	0.95	neutral	1.36	12.60	neutral	0.17	0.45	0.25	neutral	0.22	neutral	0.35	neutral	0.36	neutral	3	0.69	neutral	0.65	deleterious	-6	neutral	0.09	neutral	1.13	medium_impact	0.03	medium_impact	-0.99	medium_impact	0.68	0.85	23.95	21.91	0.49	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15731	15731	G	C	MI.10425	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	985	329	A	P	Gcc/Ccc	-0.29	0	0	possibly_damaging	0.55	neutral	0.09	neutral	2.91	neutral	-2.6	neutral	-1.33	medium_impact	3	0.94	neutral	0.4	neutral	2.26	17.92	deleterious	0.04	0.35	0.61	disease	0.85	disease	0.67	disease	0.77	disease	5	0.9	neutral	0.27	neutral	0	NA	0.43	deleterious	-0.81	medium_impact	-0.32	medium_impact	1.53	medium_impact	0.52	0.8	23.95	21.91	0.39	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15731	15731	G	T	MI.10426	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	985	329	A	S	Gcc/Tcc	-0.29	0	0	benign	0.18	neutral	0.25	neutral	2.95	neutral	-0.88	neutral	-0.99	low_impact	1.62	0.94	neutral	0.65	neutral	2.14	17.14	deleterious	0.21	0.45	0.38	neutral	0.41	neutral	0.53	disease	0.47	neutral	1	0.7	neutral	0.54	deleterious	-6	neutral	0.18	neutral	-0.12	medium_impact	-0.04	medium_impact	0.28	medium_impact	0.34	0.8	23.95	21.91	0.42	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15732	15732	C	G	MI.10427	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	986	329	A	G	gCc/gGc	-1.44	0	0	benign	0.24	neutral	0.28	neutral	2.92	neutral	-1.8	neutral	-1.83	low_impact	1.9	0.97	neutral	0.63	neutral	2.40	18.80	deleterious	0.19	0.45	0.53	disease	0.46	neutral	0.54	disease	0.51	disease	0	0.66	neutral	0.52	deleterious	-6	neutral	0.21	neutral	-0.26	medium_impact	0	medium_impact	0.53	medium_impact	0.57	0.8	23.95	21.91	0.36	N	0.57	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15732	15732	C	A	MI.10428	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	986	329	A	D	gCc/gAc	-1.44	0	0	benign	0.34	neutral	0.12	neutral	2.9	deleterious	-3	neutral	-1.79	medium_impact	2.65	0.93	neutral	0.5	neutral	3.01	22.30	deleterious	0.03	0.35	0.66	disease	0.78	disease	0.66	disease	0.74	disease	5	0.86	neutral	0.39	neutral	-3	neutral	0.34	neutral	-0.46	medium_impact	-0.25	medium_impact	1.21	medium_impact	0.39	0.8	23.95	21.91	0.35	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15732	15732	C	T	MI.10429	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	986	329	A	V	gCc/gTc	-1.44	0	0	benign	0.01	neutral	0.65	neutral	3.3	neutral	2.04	neutral	1.75	neutral_impact	-1.61	0.99	neutral	0.98	neutral	0.12	3.84	deleterious	0.15	0.4	0.22	neutral	0.06	neutral	0.29	neutral	0.17	neutral	7	0.34	neutral	0.82	deleterious	-6	neutral	0.08	neutral	1.13	medium_impact	0.37	medium_impact	-2.66	low_impact	0.61	0.8	23.95	21.91	0.42	N	0.02	polymorphism	1	0.01	rs879129589	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9016	9016	A	G	MI.1043	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	490	164	I	V	Att/Gtt	-3.34	0	0	probably_damaging	0.93	neutral	0.26	neutral	3.59	neutral	-1.58	neutral	-0.9	low_impact	1.48	0.9	neutral	0.5	neutral	2.89	21.80	deleterious	0.49	0.65	0.75	disease	0.38	neutral	0.64	disease	0.69	disease	4	0.95	neutral	0.17	neutral	-2	neutral	0.69	deleterious	-1.82	low_impact	0.04	medium_impact	0.17	medium_impact	0.61	0.9	48.67	8.91	0.48	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	CPD	0.15	A9016G	LHON	-	+	Reported	2	.	P	P	damaging
chrM	15734	15734	G	A	MI.10430	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	988	330	A	T	Gca/Aca	-6.71	0	0	benign	0.02	neutral	0.44	neutral	2.94	neutral	-1.32	neutral	-1.47	medium_impact	2.03	0.99	neutral	0.63	neutral	1.56	13.63	neutral	0.17	0.45	0.31	neutral	0.56	disease	0.34	neutral	0.33	neutral	3	0.54	neutral	0.71	deleterious	-3	neutral	0.12	neutral	0.85	medium_impact	0.17	medium_impact	0.65	medium_impact	0.75	0.85	22.63	39.24	0.41	N	0.02	polymorphism	1	0.03	rs386829259	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15734	15734	G	C	MI.10431	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	988	330	A	P	Gca/Cca	-6.71	0	0	probably_damaging	0.97	neutral	0.23	neutral	2.89	deleterious	-3.12	deleterious	-2.5	high_impact	3.51	0.94	neutral	0.29	neutral	2.35	18.49	deleterious	0.05	0.35	0.74	disease	0.88	disease	0.68	disease	0.72	disease	4	0.98	neutral	0.13	neutral	2	deleterious	0.81	deleterious	-2.14	low_impact	-0.06	medium_impact	1.99	medium_impact	0.47	0.8	22.63	39.24	0.38	N	0.82	polymorphism	1	0.05	rs386829259	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15734	15734	G	T	MI.10432	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	988	330	A	S	Gca/Tca	-6.71	0	0	benign	0.41	neutral	0.45	neutral	2.96	neutral	-1.31	neutral	-1.25	low_impact	1.43	0.97	neutral	0.72	neutral	0.97	10.51	neutral	0.21	0.45	0.47	neutral	0.5	disease	0.32	neutral	0.36	neutral	3	0.49	neutral	0.52	deleterious	-6	neutral	0.28	neutral	-0.58	medium_impact	0.18	medium_impact	0.11	medium_impact	0.45	0.8	22.63	39.24	0.32	N	0.56	polymorphism	1	0.03	rs386829259	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15735	15735	C	G	MI.10433	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	989	330	A	G	gCa/gGa	0.86	0.11	0	benign	0.2	neutral	0.37	neutral	2.91	neutral	-2.25	neutral	-2.15	medium_impact	2.27	0.93	neutral	0.52	neutral	2.41	18.91	deleterious	0.2	0.45	0.67	disease	0.66	disease	0.38	neutral	0.39	neutral	2	0.56	neutral	0.59	deleterious	-3	neutral	0.32	neutral	-0.17	medium_impact	0.1	medium_impact	0.87	medium_impact	0.56	0.8	22.63	39.24	0.33	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15735	15735	C	A	MI.10434	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	989	330	A	E	gCa/gAa	0.86	0.11	0	probably_damaging	0.95	neutral	0.33	neutral	2.89	neutral	-2.79	neutral	-2.47	high_impact	4.21	0.93	neutral	0.42	neutral	2.95	22.00	deleterious	0.04	0.35	0.61	disease	0.87	disease	0.68	disease	0.72	disease	4	0.96	neutral	0.19	neutral	2	deleterious	0.77	deleterious	-1.92	low_impact	0.06	medium_impact	2.63	high_impact	0.33	0.8	22.63	39.24	0.45	N	0.85	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15735	15735	C	T	MI.10435	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	989	330	A	V	gCa/gTa	0.86	0.11	0	benign	0.02	neutral	0.57	neutral	3.08	neutral	0.38	neutral	-1.72	medium_impact	2.08	0.97	neutral	0.57	neutral	2.93	22.00	deleterious	0.13	0.4	0.32	neutral	0.74	disease	0.39	neutral	0.42	neutral	2	0.4	neutral	0.78	deleterious	-3	neutral	0.16	neutral	0.85	medium_impact	0.29	medium_impact	0.7	medium_impact	0.69	0.85	22.63	39.24	0.27	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15737	15737	G	T	MI.10436	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	991	331	D	Y	Gac/Tac	-6.02	0	0	probably_damaging	0.93	neutral	1	neutral	3.13	neutral	-0.85	deleterious	-3.36	high_impact	4.04	0.91	neutral	0.54	neutral	2.35	18.49	deleterious	0.07	0.35	0.67	disease	0.91	disease	0.59	disease	0.67	disease	3	0.93	neutral	0.54	deleterious	2	deleterious	0.79	deleterious	-1.78	low_impact	1.85	high_impact	2.48	high_impact	0.11	0.8	24.74	40.07	0.27	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15737	15737	G	A	MI.10437	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	991	331	D	N	Gac/Aac	-6.02	0	0	benign	0.01	neutral	0.44	neutral	3.2	neutral	0.45	neutral	0.1	neutral_impact	-0.27	0.88	neutral	0.94	neutral	0.68	8.66	deleterious	0.33	0.5	0.25	neutral	0.26	neutral	0.34	neutral	0.41	neutral	2	0.55	neutral	0.72	deleterious	-6	neutral	0.14	neutral	1.13	medium_impact	0.17	medium_impact	-1.44	low_impact	0.70	0.85	24.74	40.07	0.37	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15737	15737	G	C	MI.10438	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	991	331	D	H	Gac/Cac	-6.02	0	0	possibly_damaging	0.89	neutral	0.56	neutral	3.1	neutral	-1.78	neutral	-1.96	high_impact	3.69	0.9	neutral	0.44	neutral	2.10	16.87	deleterious	0.1	0.4	0.56	disease	0.82	disease	0.66	disease	0.66	disease	3	0.88	neutral	0.34	neutral	1	deleterious	0.71	deleterious	-1.58	low_impact	0.28	medium_impact	2.16	high_impact	0.24	0.8	24.74	40.07	0.29	N	0.48	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15738	15738	A	C	MI.10439	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	992	331	D	A	gAc/gCc	0.4	0.03	0	benign	0.31	neutral	0.78	neutral	3.18	neutral	0.19	deleterious	-3.06	medium_impact	2.27	0.92	neutral	0.56	neutral	2.05	16.53	deleterious	0.11	0.4	0.34	neutral	0.81	disease	0.49	neutral	0.62	disease	2	0.2	neutral	0.74	deleterious	-3	neutral	0.43	neutral	-0.41	medium_impact	0.52	medium_impact	0.87	medium_impact	0.26	0.8	24.74	40.07	0.23	N	0.64	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9017	9017	T	C	MI.1044	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	491	164	I	T	aTt/aCt	1.29	0.73	0	probably_damaging	0.99	deleterious	0	neutral	3.47	deleterious	-3.9	deleterious	-3.81	medium_impact	2.46	0.82	neutral	0.45	neutral	3.43	23.00	deleterious	0.35	0.65	0.92	disease	0.55	disease	0.65	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-2.65	low_impact	-1.4	low_impact	1.01	medium_impact	0.65	0.9	48.67	8.91	0.28	N	0.99	polymorphism	0.98	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15738	15738	A	G	MI.10440	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	992	331	D	G	gAc/gGc	0.4	0.03	0	possibly_damaging	0.5	neutral	0.45	neutral	3.13	neutral	-0.87	neutral	-2.29	medium_impact	3.49	0.91	neutral	0.46	neutral	2.38	18.67	deleterious	0.1	0.4	0.52	disease	0.81	disease	0.57	disease	0.64	disease	3	0.54	neutral	0.48	deleterious	0	NA	0.40	neutral	-0.73	medium_impact	0.18	medium_impact	1.98	medium_impact	0.29	0.8	24.74	40.07	0.34	N	0.43	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15738	15738	A	T	MI.10441	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	992	331	D	V	gAc/gTc	0.4	0.03	0	benign	0.18	neutral	0.68	neutral	3.2	neutral	0.39	deleterious	-3.53	low_impact	1.54	0.93	neutral	0.86	neutral	2.11	16.89	deleterious	0.07	0.35	0.39	neutral	0.86	disease	0.37	neutral	0.49	neutral	0	0.2	neutral	0.75	deleterious	-6	neutral	0.28	neutral	-0.12	medium_impact	0.4	medium_impact	0.21	medium_impact	0.11	0.8	24.74	40.07	0.25	N	0.80	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15739	15739	C	A	MI.10442	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	993	331	D	E	gaC/gaA	3.83	0.43	0	benign	0.13	neutral	0.48	neutral	3.11	neutral	-1.23	neutral	-1.41	high_impact	4.04	0.9	neutral	0.49	neutral	2.72	20.90	deleterious	0.2	0.45	0.3	neutral	0.81	disease	0.54	disease	0.64	disease	3	0.44	neutral	0.68	deleterious	-2	neutral	0.24	neutral	0.04	medium_impact	0.2	medium_impact	2.48	high_impact	0.55	0.8	24.74	40.07	0.42	N	0.42	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15739	15739	C	G	MI.10443	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	993	331	D	E	gaC/gaG	3.83	0.43	0	benign	0.13	neutral	0.48	neutral	3.11	neutral	-1.23	neutral	-1.41	high_impact	4.04	0.9	neutral	0.49	neutral	2.38	18.71	deleterious	0.2	0.45	0.3	neutral	0.81	disease	0.54	disease	0.64	disease	3	0.44	neutral	0.68	deleterious	-2	neutral	0.24	neutral	0.04	medium_impact	0.2	medium_impact	2.48	high_impact	0.55	0.8	24.74	40.07	0.42	N	0.42	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15740	15740	C	A	MI.10444	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	994	332	L	I	Ctc/Atc	-0.98	0	0	probably_damaging	0.99	neutral	0.5	neutral	2.97	neutral	-0.3	neutral	0	low_impact	0.94	0.81	neutral	0.46	neutral	1.48	13.23	neutral	0.32	0.5	0.36	neutral	0.29	neutral	0.24	neutral	0.45	neutral	1	0.99	deleterious	0.26	neutral	-2	neutral	0.67	deleterious	-2.59	low_impact	0.22	medium_impact	-0.34	medium_impact	0.50	0.8	58.16	9.29	0.31	N	0.86	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15740	15740	C	T	MI.10445	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	994	332	L	F	Ctc/Ttc	-0.98	0	0	probably_damaging	1	neutral	0.73	neutral	3.14	neutral	0.96	neutral	-1.58	neutral_impact	0.23	0.84	neutral	0.47	neutral	2.38	18.68	deleterious	0.24	0.45	0.27	neutral	0.53	disease	0.28	neutral	0.25	neutral	5	1	deleterious	0.37	neutral	-2	neutral	0.68	deleterious	-3.53	low_impact	0.46	medium_impact	-0.98	medium_impact	0.50	0.8	58.16	9.29	0.19	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15740	15740	C	G	MI.10446	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	994	332	L	V	Ctc/Gtc	-0.98	0	0	probably_damaging	0.98	neutral	0.65	neutral	2.99	neutral	-0.13	neutral	-0.15	neutral_impact	0.51	0.91	neutral	0.53	neutral	0.47	7.23	deleterious	0.34	0.5	0.26	neutral	0.08	neutral	0.25	neutral	0.24	neutral	5	0.97	neutral	0.34	neutral	-2	neutral	0.64	deleterious	-2.31	low_impact	0.37	medium_impact	-0.73	medium_impact	0.54	0.8	58.16	9.29	0.36	N	0.91	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15741	15741	T	A	MI.10447	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	995	332	L	H	cTc/cAc	-0.06	0	0	probably_damaging	1	neutral	0.53	neutral	2.85	deleterious	-3.01	deleterious	-3.06	high_impact	3.94	0.82	neutral	0.31	neutral	2.60	20.20	deleterious	0.04	0.35	0.71	disease	0.68	disease	0.63	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.25	medium_impact	2.38	high_impact	0.23	0.8	58.16	9.29	0.26	N	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15741	15741	T	C	MI.10448	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	995	332	L	P	cTc/cCc	-0.06	0	0	probably_damaging	1	neutral	0.24	neutral	2.85	deleterious	-3.07	deleterious	-2.89	high_impact	3.6	0.83	neutral	0.27	damaging	2.37	18.60	deleterious	0.02	0.35	0.71	disease	0.86	disease	0.68	disease	0.73	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.05	medium_impact	2.08	high_impact	0.16	0.8	58.16	9.29	0.31	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15741	15741	T	G	MI.10449	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	995	332	L	R	cTc/cGc	-0.06	0	0	probably_damaging	1	neutral	0.35	neutral	2.86	neutral	-2.42	deleterious	-2.71	medium_impact	3.4	0.84	neutral	0.31	neutral	2.68	20.70	deleterious	0.02	0.35	0.63	disease	0.84	disease	0.66	disease	0.73	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.08	medium_impact	1.89	medium_impact	0.24	0.8	58.16	9.29	0.27	N	0.99	polymorphism	1	0.08	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9017	9017	T	A	MI.1045	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	491	164	I	N	aTt/aAt	1.29	0.73	0	probably_damaging	1	deleterious	0	neutral	3.46	deleterious	-6.17	deleterious	-5.65	medium_impact	3	0.82	neutral	0.43	neutral	4.47	24.20	deleterious	0.26	0.65	0.98	disease	0.81	disease	0.65	disease	0.85	disease	7	1	deleterious	0	neutral	5	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	1.47	medium_impact	0.64	0.9	48.67	8.91	0.31	N	1.00	polymorphism	0.93	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15743	15743	C	T	MI.10450	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	997	333	L	F	Ctc/Ttc	-10.6	0	0	probably_damaging	1	neutral	0.79	neutral	2.91	neutral	-0.64	neutral	-1.5	low_impact	0.83	0.94	neutral	0.94	neutral	1.10	11.23	neutral	0.18	0.45	0.37	neutral	0.31	neutral	0.37	neutral	0.44	neutral	1	1	deleterious	0.4	neutral	-2	neutral	0.15	neutral	-3.53	low_impact	0.53	medium_impact	-0.44	medium_impact	0.52	0.8	19.21	17.39	0.29	N	0.97	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15743	15743	C	G	MI.10451	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	997	333	L	V	Ctc/Gtc	-10.6	0	0	probably_damaging	0.98	neutral	0.57	neutral	2.93	neutral	-0.45	neutral	-0.97	low_impact	1.28	0.94	neutral	0.85	neutral	0.83	9.65	deleterious	0.28	0.45	0.3	neutral	0.32	neutral	0.36	neutral	0.43	neutral	1	0.97	neutral	0.3	neutral	-2	neutral	0.16	neutral	-2.31	low_impact	0.29	medium_impact	-0.03	medium_impact	0.55	0.8	19.21	17.39	0.34	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15743	15743	C	A	MI.10452	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	997	333	L	I	Ctc/Atc	-10.6	0	0	probably_damaging	0.99	neutral	0.67	neutral	2.94	neutral	-0.37	neutral	-0.51	neutral_impact	0.68	0.91	neutral	0.91	neutral	1.24	11.97	neutral	0.27	0.45	0.28	neutral	0.2	neutral	0.28	neutral	0.34	neutral	3	0.99	deleterious	0.34	neutral	-2	neutral	0.18	neutral	-2.59	low_impact	0.39	medium_impact	-0.58	medium_impact	0.46	0.8	19.21	17.39	0.34	N	0.86	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15744	15744	T	A	MI.10453	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	998	333	L	H	cTc/cAc	-5.33	0	0	probably_damaging	1	neutral	0.46	neutral	2.75	deleterious	-3.85	deleterious	-3.37	high_impact	3.94	0.82	neutral	0.45	neutral	2.61	20.20	deleterious	0.05	0.35	0.73	disease	0.68	disease	0.68	disease	0.69	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.71	deleterious	-3.53	low_impact	0.18	medium_impact	2.38	high_impact	0.22	0.8	19.21	17.39	0.34	N	0.95	polymorphism	1	0.19	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15744	15744	T	G	MI.10454	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	998	333	L	R	cTc/cGc	-5.33	0	0	probably_damaging	1	neutral	0.3	neutral	2.76	deleterious	-3.3	deleterious	-3.04	high_impact	4.29	0.84	neutral	0.44	neutral	2.66	20.60	deleterious	0.02	0.35	0.65	disease	0.83	disease	0.72	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	0.02	medium_impact	2.7	high_impact	0.18	0.8	19.21	17.39	0.42	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15744	15744	T	C	MI.10455	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	998	333	L	P	cTc/cCc	-5.33	0	0	probably_damaging	1	neutral	0.29	neutral	2.75	deleterious	-3.89	deleterious	-3.47	high_impact	3.94	0.83	neutral	0.33	neutral	2.36	18.59	deleterious	0.03	0.35	0.74	disease	0.84	disease	0.73	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.01	medium_impact	2.38	high_impact	0.28	0.8	19.21	17.39	0.35	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15746	15746	A	G	MI.10456	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1000	334	I	V	Att/Gtt	-11.75	0	0.01	benign	0	neutral	0.58	neutral	3.01	neutral	0.2	neutral	-0.38	low_impact	1.02	0.94	neutral	0.89	neutral	0.28	5.48	deleterious	0.52	0.6	0.3	neutral	0.22	neutral	0.38	neutral	0.38	neutral	2	0.42	neutral	0.79	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.3	medium_impact	-0.27	medium_impact	0.39	0.8	17.63	23.86	0.35	N	0.71	polymorphism	1	0.01	rs386829260	Benign	not_provided	237304	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15746	15746	A	C	MI.10457	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1000	334	I	L	Att/Ctt	-11.75	0	0.01	benign	0.06	neutral	1	neutral	3.06	neutral	-0.34	neutral	-0.89	low_impact	0.86	0.9	neutral	0.71	neutral	2.23	17.73	deleterious	0.28	0.45	0.17	neutral	0.59	disease	0.27	neutral	0.27	neutral	5	0.06	neutral	0.97	deleterious	-6	neutral	0.12	neutral	0.38	medium_impact	1.85	high_impact	-0.41	medium_impact	0.46	0.8	17.63	23.86	0.3	N	0.62	polymorphism	1	0.02	rs386829260	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15746	15746	A	T	MI.10458	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1000	334	I	F	Att/Ttt	-11.75	0	0.01	possibly_damaging	0.45	neutral	0.63	neutral	2.9	neutral	-1.6	neutral	-2.15	medium_impact	2.77	0.85	neutral	0.55	neutral	2.25	17.86	deleterious	0.18	0.45	0.41	neutral	0.79	disease	0.54	disease	0.65	disease	3	0.38	neutral	0.59	deleterious	0	NA	0.37	neutral	-0.65	medium_impact	0.35	medium_impact	1.32	medium_impact	0.49	0.8	17.63	23.86	0.22	N	0.67	polymorphism	1	0.03	rs386829260	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15747	15747	T	G	MI.10459	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1001	334	I	S	aTt/aGt	0.4	0	0	benign	0.36	neutral	0.34	neutral	2.88	neutral	-1.87	deleterious	-3.02	medium_impact	3.12	0.84	neutral	0.51	neutral	2.75	21.10	deleterious	0.04	0.35	0.51	disease	0.81	disease	0.56	disease	0.65	disease	3	0.6	neutral	0.49	deleterious	-3	neutral	0.33	neutral	-0.5	medium_impact	0.07	medium_impact	1.64	medium_impact	0.21	0.8	17.63	23.86	0.3	N	0.54	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9017	9017	T	G	MI.1046	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	491	164	I	S	aTt/aGt	1.29	0.73	0	probably_damaging	0.99	deleterious	0	neutral	3.46	deleterious	-5.01	deleterious	-4.71	medium_impact	3	0.8	neutral	0.49	neutral	4.32	24.00	deleterious	0.23	0.65	0.96	disease	0.76	disease	0.63	disease	0.84	disease	7	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-2.65	low_impact	-1.4	low_impact	1.47	medium_impact	0.50	0.9	48.67	8.91	0.28	N	0.98	polymorphism	0.91	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15747	15747	T	A	MI.10460	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1001	334	I	N	aTt/aAt	0.4	0	0	possibly_damaging	0.48	neutral	0.2	neutral	2.84	neutral	-2.44	deleterious	-3.63	high_impact	4.13	0.83	neutral	0.53	neutral	2.89	21.80	deleterious	0.09	0.35	0.69	disease	0.86	disease	0.6	disease	0.7	disease	4	0.78	neutral	0.36	neutral	1	deleterious	0.49	deleterious	-0.7	medium_impact	-0.1	medium_impact	2.56	high_impact	0.29	0.8	17.63	23.86	0.41	N	0.76	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15747	15747	T	C	MI.10461	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1001	334	I	T	aTt/aCt	0.4	0	0	benign	0.01	neutral	0.65	neutral	2.9	neutral	-1.54	neutral	-2.19	low_impact	1.45	0.97	neutral	0.95	neutral	-0.32	0.59	neutral	0.1	0.4	0.31	neutral	0.37	neutral	0.42	neutral	0.44	neutral	1	0.32	neutral	0.82	deleterious	-6	neutral	0.11	neutral	1.13	medium_impact	0.37	medium_impact	0.12	medium_impact	0.19	0.8	17.63	23.86	0.27	N	0.04	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15748	15748	T	A	MI.10462	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1002	334	I	M	atT/atA	1.31	0	0	possibly_damaging	0.69	neutral	0.33	neutral	2.9	neutral	-1.85	neutral	-1.4	medium_impact	2.68	0.9	neutral	0.47	neutral	2.21	17.56	deleterious	0.37	0.5	0.51	disease	0.58	disease	0.39	neutral	0.38	neutral	2	0.75	neutral	0.32	neutral	0	NA	0.39	neutral	-1.06	low_impact	0.06	medium_impact	1.24	medium_impact	0.52	0.8	17.63	23.86	0.37	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15748	15748	T	G	MI.10463	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1002	334	I	M	atT/atG	1.31	0	0	possibly_damaging	0.69	neutral	0.33	neutral	2.9	neutral	-1.85	neutral	-1.4	medium_impact	2.68	0.9	neutral	0.47	neutral	1.86	15.33	deleterious	0.37	0.5	0.51	disease	0.58	disease	0.39	neutral	0.38	neutral	2	0.75	neutral	0.32	neutral	0	NA	0.39	neutral	-1.06	low_impact	0.06	medium_impact	1.24	medium_impact	0.52	0.8	17.63	23.86	0.37	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15749	15749	C	A	MI.10464	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1003	335	L	M	Cta/Ata	-5.79	0	0	probably_damaging	1	neutral	0.23	neutral	1.81	deleterious	-4.79	neutral	-1.21	high_impact	4.39	0.87	neutral	0.1	damaging	2.18	17.40	deleterious	0.18	0.45	0.8	disease	0.56	disease	0.71	disease	0.69	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	-0.06	medium_impact	2.79	high_impact	0.54	0.8	56.58	8.6	0.44	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15749	15749	C	G	MI.10465	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1003	335	L	V	Cta/Gta	-5.79	0	0	probably_damaging	0.99	neutral	0.66	neutral	1.85	deleterious	-4.05	neutral	-1.82	high_impact	4.94	0.87	neutral	0.11	damaging	1.88	15.45	deleterious	0.16	0.45	0.72	disease	0.57	disease	0.73	disease	0.7	disease	4	0.99	deleterious	0.34	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.38	medium_impact	3.29	high_impact	0.56	0.8	56.58	8.6	0.64	P	0.91	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15750	15750	T	C	MI.10466	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1004	335	L	P	cTa/cCa	1.77	0.88	0	probably_damaging	1	neutral	0.25	neutral	1.74	deleterious	-7.89	deleterious	-4.25	high_impact	5.29	0.87	neutral	0.05	damaging	2.32	18.32	deleterious	0.02	0.35	0.91	disease	0.79	disease	0.81	disease	0.76	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.04	medium_impact	3.61	high_impact	0.35	0.8	56.58	8.6	0.66	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15750	15750	T	G	MI.10467	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1004	335	L	R	cTa/cGa	1.77	0.88	0	probably_damaging	1	neutral	0.16	neutral	1.75	deleterious	-7.27	deleterious	-3.64	high_impact	5.29	0.87	neutral	0.06	damaging	2.55	19.81	deleterious	0.02	0.35	0.72	disease	0.86	disease	0.81	disease	0.72	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.17	medium_impact	3.61	high_impact	0.22	0.8	56.58	8.6	0.67	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15750	15750	T	A	MI.10468	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1004	335	L	Q	cTa/cAa	1.77	0.88	0	probably_damaging	1	neutral	0.19	neutral	1.75	deleterious	-7.29	deleterious	-3.64	high_impact	4.94	0.86	neutral	0.07	damaging	2.44	19.08	deleterious	0.02	0.35	0.82	disease	0.76	disease	0.73	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.12	medium_impact	3.29	high_impact	0.32	0.8	56.58	8.6	0.65	P	0.98	polymorphism	1	0.20	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15752	15752	A	T	MI.10469	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1006	336	T	S	Acc/Tcc	-6.71	0	0	probably_damaging	0.98	neutral	0.23	neutral	2.88	neutral	-1.95	neutral	-2.42	medium_impact	3.43	0.84	neutral	0.49	neutral	1.77	14.80	neutral	0.29	0.45	0.42	neutral	0.74	disease	0.63	disease	0.65	disease	3	0.98	deleterious	0.13	neutral	1	deleterious	0.74	deleterious	-2.31	low_impact	-0.06	medium_impact	1.92	medium_impact	0.62	0.8	58.42	8.25	0.31	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9018	9018	T	A	MI.1047	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	492	164	I	M	atT/atA	7.53	0.98	0.01	probably_damaging	1	neutral	0.69	neutral	3.86	neutral	0.82	neutral	-1.74	neutral_impact	0.28	0.82	neutral	0.43	neutral	3.70	23.30	deleterious	0.5	0.65	0.29	neutral	0.27	neutral	0.3	neutral	0.44	neutral	1	0.99	deleterious	0.35	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.49	medium_impact	-0.86	medium_impact	0.84	0.9	48.67	8.91	0.45	N	0.75	polymorphism	0.95	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15752	15752	A	C	MI.10470	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1006	336	T	P	Acc/Ccc	-6.71	0	0	probably_damaging	1	neutral	0.3	neutral	2.79	deleterious	-3.89	deleterious	-3.63	high_impact	4.69	0.84	neutral	0.32	neutral	1.94	15.83	deleterious	0.05	0.35	0.75	disease	0.85	disease	0.79	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.02	medium_impact	3.07	high_impact	0.35	0.8	58.42	8.25	0.67	P	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15752	15752	A	G	MI.10471	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1006	336	T	A	Acc/Gcc	-6.71	0	0	probably_damaging	0.98	neutral	0.39	neutral	2.87	neutral	-2.09	deleterious	-3.02	high_impact	3.75	0.78	neutral	0.54	neutral	1.98	16.05	deleterious	0.13	0.4	0.42	neutral	0.71	disease	0.67	disease	0.66	disease	3	0.98	neutral	0.21	neutral	2	deleterious	0.73	deleterious	-2.31	low_impact	0.12	medium_impact	2.21	high_impact	0.31	0.8	58.42	8.25	0.33	N	0.59	polymorphism	1	0.05	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15753	15753	C	T	MI.10472	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1007	336	T	I	aCc/aTc	8.42	1	0	probably_damaging	1	neutral	0.53	neutral	2.84	neutral	-2.58	deleterious	-3.63	high_impact	3.88	0.84	neutral	0.48	neutral	2.39	18.73	deleterious	0.1	0.4	0.53	disease	0.88	disease	0.67	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.25	medium_impact	2.33	high_impact	0.57	0.8	58.42	8.25	0.52	N	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15753	15753	C	G	MI.10473	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1007	336	T	S	aCc/aGc	8.42	1	0	probably_damaging	0.98	neutral	0.23	neutral	2.88	neutral	-1.95	neutral	-2.42	medium_impact	3.43	0.84	neutral	0.49	neutral	1.96	15.95	deleterious	0.29	0.45	0.42	neutral	0.74	disease	0.63	disease	0.65	disease	3	0.98	deleterious	0.13	neutral	1	deleterious	0.74	deleterious	-2.31	low_impact	-0.06	medium_impact	1.92	medium_impact	0.62	0.8	58.42	8.25	0.53	P	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15753	15753	C	A	MI.10474	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1007	336	T	N	aCc/aAc	8.42	1	0	probably_damaging	1	neutral	0.17	neutral	2.79	deleterious	-3.77	deleterious	-3.02	high_impact	4.69	0.83	neutral	0.44	neutral	2.26	17.92	deleterious	0.21	0.45	0.65	disease	0.86	disease	0.68	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	-0.15	medium_impact	3.07	high_impact	0.50	0.8	58.42	8.25	0.67	P	0.84	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15755	15755	T	G	MI.10475	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1009	337	W	G	Tga/Gga	-0.75	0.17	0	probably_damaging	1	neutral	0.33	neutral	2.75	deleterious	-3.46	deleterious	-7.81	high_impact	4.72	0.75	neutral	0.13	damaging	2.41	18.90	deleterious	0.04	0.35	0.65	disease	0.85	disease	0.81	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.06	medium_impact	3.09	high_impact	0.09	0.8	57.89	8.66	0.65	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15755	15755	T	C	MI.10476	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1009	337	W	R	Tga/Cga	-0.75	0.17	0	probably_damaging	1	neutral	0.35	neutral	2.75	deleterious	-3.32	deleterious	-8.41	high_impact	4.52	0.81	neutral	0.07	damaging	2.02	16.35	deleterious	0.03	0.35	0.64	disease	0.92	disease	0.85	disease	0.78	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.08	medium_impact	2.91	high_impact	0.12	0.8	57.89	8.66	0.54	N	0.99	polymorphism	1	0.11	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15756	15756	G	C	MI.10477	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1010	337	W	S	tGa/tCa	7.27	1	0	probably_damaging	1	neutral	0.4	neutral	2.78	neutral	-2.43	deleterious	-8.41	high_impact	4.38	0.74	neutral	0.1	damaging	2.48	19.37	deleterious	0.04	0.35	0.53	disease	0.91	disease	0.8	disease	0.75	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.13	medium_impact	2.78	high_impact	0.07	0.8	57.89	8.66	0.59	P	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15756	15756	G	T	MI.10478	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1010	337	W	L	tGa/tTa	7.27	1	0	probably_damaging	1	neutral	0.65	neutral	2.87	neutral	-0.99	deleterious	-7.81	high_impact	4.09	0.75	neutral	0.08	damaging	2.70	20.80	deleterious	0.04	0.35	0.36	neutral	0.88	disease	0.79	disease	0.73	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.37	medium_impact	2.52	high_impact	0.07	0.8	57.89	8.66	0.55	P	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15757	15757	A	C	MI.10479	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1011	337	W	C	tgA/tgC	8.88	1	0.01	probably_damaging	1	neutral	0.18	neutral	2.74	deleterious	-3.86	deleterious	-7.81	high_impact	4.38	0.77	neutral	0.05	damaging	2.48	19.32	deleterious	0.03	0.35	0.74	disease	0.9	disease	0.85	disease	0.78	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.14	medium_impact	2.78	high_impact	0.08	0.8	57.89	8.66	0.55	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9018	9018	T	G	MI.1048	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	492	164	I	M	atT/atG	7.53	0.98	0.01	probably_damaging	1	neutral	0.69	neutral	3.86	neutral	0.82	neutral	-1.74	neutral_impact	0.28	0.82	neutral	0.43	neutral	3.41	23.00	deleterious	0.5	0.65	0.29	neutral	0.27	neutral	0.3	neutral	0.44	neutral	1	0.99	deleterious	0.35	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.49	medium_impact	-0.86	medium_impact	0.84	0.9	48.67	8.91	0.45	N	0.75	polymorphism	0.95	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15757	15757	A	T	MI.10480	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1011	337	W	C	tgA/tgT	8.88	1	0.01	probably_damaging	1	neutral	0.18	neutral	2.74	deleterious	-3.86	deleterious	-7.81	high_impact	4.38	0.77	neutral	0.05	damaging	2.62	20.30	deleterious	0.03	0.35	0.74	disease	0.9	disease	0.85	disease	0.78	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.14	medium_impact	2.78	high_impact	0.08	0.8	57.89	8.66	0.56	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15758	15758	A	G	MI.10481	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1012	338	I	V	Atc/Gtc	5.44	1	0.05	benign	0.01	neutral	0.5	neutral	2.95	neutral	-0.35	neutral	-0.44	medium_impact	1.98	0.89	neutral	0.57	neutral	1.58	13.73	neutral	0.39	0.5	0.31	neutral	0.44	neutral	0.49	neutral	0.4	neutral	2	0.49	neutral	0.75	deleterious	-3	neutral	0.15	neutral	1.13	medium_impact	0.22	medium_impact	0.6	medium_impact	0.57	0.8	49.74	7.97	0.61	P	0.83	polymorphism	1	0.01	rs527236193	Likely_pathogenic	Familial_cancer_of_breast	153623	MedGen:C0346153,OMIM:114480,Orphanet:ORPHA227535,SNOMED_CT:254843006	.	.	.	0.74	.	.	.	.	.	.	P	.	P	neutral
chrM	15758	15758	A	T	MI.10482	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1012	338	I	F	Atc/Ttc	5.44	1	0.05	possibly_damaging	0.79	neutral	0.71	neutral	2.81	neutral	-2.16	neutral	-2.37	medium_impact	3.44	0.85	neutral	0.36	neutral	2.33	18.36	deleterious	0.08	0.35	0.55	disease	0.85	disease	0.71	disease	0.73	disease	5	0.75	neutral	0.46	neutral	0	NA	0.75	deleterious	-1.27	low_impact	0.43	medium_impact	1.93	medium_impact	0.66	0.8	49.74	7.97	0.49	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15758	15758	A	C	MI.10483	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1012	338	I	L	Atc/Ctc	5.44	1	0.05	benign	0.15	neutral	0.7	neutral	3.13	neutral	0.65	neutral	-1.16	low_impact	1.37	0.84	neutral	0.34	neutral	2.34	18.46	deleterious	0.22	0.45	0.21	neutral	0.72	disease	0.41	neutral	0.49	neutral	0	0.18	neutral	0.78	deleterious	-6	neutral	0.19	neutral	-0.03	medium_impact	0.42	medium_impact	0.05	medium_impact	0.61	0.8	49.74	7.97	0.43	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15759	15759	T	G	MI.10484	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1013	338	I	S	aTc/aGc	3.61	1	0	probably_damaging	0.95	neutral	0.44	neutral	2.81	neutral	-2.16	deleterious	-3.47	high_impact	3.75	0.84	neutral	0.38	neutral	2.82	21.50	deleterious	0.03	0.35	0.49	neutral	0.87	disease	0.71	disease	0.74	disease	5	0.95	neutral	0.25	neutral	2	deleterious	0.74	deleterious	-1.92	low_impact	0.17	medium_impact	2.21	high_impact	0.23	0.8	49.74	7.97	0.45	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15759	15759	T	A	MI.10485	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1013	338	I	N	aTc/aAc	3.61	1	0	probably_damaging	0.97	neutral	0.31	neutral	2.78	deleterious	-3.43	deleterious	-4.08	high_impact	4.44	0.83	neutral	0.36	neutral	3.05	22.40	deleterious	0.06	0.35	0.63	disease	0.89	disease	0.69	disease	0.73	disease	5	0.98	neutral	0.17	neutral	2	deleterious	0.81	deleterious	-2.14	low_impact	0.03	medium_impact	2.84	high_impact	0.27	0.8	49.74	7.97	0.54	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15759	15759	T	C	MI.10486	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1013	338	I	T	aTc/aCc	3.61	1	0	benign	0.38	neutral	0.42	neutral	2.83	neutral	-1.77	deleterious	-2.8	medium_impact	3.46	0.74	neutral	0.41	neutral	1.97	16.01	deleterious	0.05	0.35	0.36	neutral	0.79	disease	0.68	disease	0.68	disease	4	0.51	neutral	0.52	deleterious	-3	neutral	0.30	neutral	-0.53	medium_impact	0.15	medium_impact	1.95	medium_impact	0.25	0.8	49.74	7.97	0.45	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15760	15760	C	A	MI.10487	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1014	338	I	M	atC/atA	7.27	1	0	possibly_damaging	0.89	neutral	0.22	neutral	2.83	neutral	-1.75	neutral	-1.68	high_impact	3.59	0.9	neutral	0.37	neutral	2.33	18.37	deleterious	0.12	0.4	0.55	disease	0.71	disease	0.61	disease	0.65	disease	3	0.93	neutral	0.17	neutral	1	deleterious	0.53	deleterious	-1.58	low_impact	-0.08	medium_impact	2.07	high_impact	0.67	0.85	49.74	7.97	0.57	P	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15760	15760	C	G	MI.10488	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1014	338	I	M	atC/atG	7.27	1	0	possibly_damaging	0.89	neutral	0.22	neutral	2.83	neutral	-1.75	neutral	-1.68	high_impact	3.59	0.9	neutral	0.37	neutral	1.83	15.19	deleterious	0.12	0.4	0.55	disease	0.71	disease	0.61	disease	0.65	disease	3	0.93	neutral	0.17	neutral	1	deleterious	0.53	deleterious	-1.58	low_impact	-0.08	medium_impact	2.07	high_impact	0.67	0.85	49.74	7.97	0.56	P	0.83	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15761	15761	G	T	MI.10489	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1015	339	G	W	Gga/Tga	-5.56	0	0	probably_damaging	1	neutral	0.2	neutral	1.77	deleterious	-10.02	deleterious	-4.8	high_impact	5.27	0.86	neutral	0.05	damaging	2.86	21.70	deleterious	0.04	0.35	0.97	disease	0.92	disease	0.81	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	-0.1	medium_impact	3.59	high_impact	0.04	0.8	58.42	8.46	0.64	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9019	9019	A	C	MI.1049	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	493	165	T	P	Act/Cct	-9.59	0	0	probably_damaging	1	deleterious	0.01	neutral	4.23	deleterious	-3.38	deleterious	-5.47	high_impact	4.1	0.47	damaging	0.5	neutral	3.54	23.10	deleterious	0.12	0.65	0.85	disease	0.91	disease	0.76	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-0.84	medium_impact	2.42	high_impact	0.57	0.9	48.67	8.72	0.45	N	0.99	polymorphism	0.6	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15761	15761	G	C	MI.10490	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1015	339	G	R	Gga/Cga	-5.56	0	0	probably_damaging	1	neutral	0.33	neutral	1.78	deleterious	-7.4	deleterious	-4.8	high_impact	5.27	0.79	neutral	0.03	damaging	2.38	18.66	deleterious	0.03	0.35	0.76	disease	0.92	disease	0.84	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	0.06	medium_impact	3.59	high_impact	0.38	0.8	58.42	8.46	0.68	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15762	15762	G	A	MI.10491	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1016	339	G	E	gGa/gAa	8.88	1	0	probably_damaging	1	neutral	0.28	neutral	1.79	deleterious	-6.83	deleterious	-4.8	high_impact	4.72	0.72	neutral	0.04	damaging	2.34	18.41	deleterious	0.04	0.35	0.7	disease	0.9	disease	0.84	disease	0.77	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0	medium_impact	3.09	high_impact	0.16	0.8	58.42	8.46	0.77	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	G15762A	MM	-	+	Reported	1	.	P	P	damaging
chrM	15762	15762	G	T	MI.10492	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1016	339	G	V	gGa/gTa	8.88	1	0	probably_damaging	1	neutral	0.52	neutral	1.79	deleterious	-7.06	deleterious	-5.4	high_impact	4.92	0.81	neutral	0.06	damaging	2.28	18.03	deleterious	0.04	0.35	0.81	disease	0.91	disease	0.78	disease	0.74	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.24	medium_impact	3.27	high_impact	0.11	0.8	58.42	8.46	0.74	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15762	15762	G	C	MI.10493	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1016	339	G	A	gGa/gCa	8.88	1	0	probably_damaging	1	neutral	0.52	neutral	2	deleterious	-3.23	deleterious	-3.6	high_impact	3.88	0.86	neutral	0.07	damaging	1.59	13.82	neutral	0.06	0.35	0.51	disease	0.78	disease	0.73	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.24	medium_impact	2.33	high_impact	0.28	0.8	58.42	8.46	0.54	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15764	15764	G	C	MI.10494	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1018	340	G	R	Gga/Cga	-2.12	0	0	probably_damaging	1	neutral	0.34	neutral	3.07	neutral	-0.31	deleterious	-3.54	medium_impact	3.43	0.83	neutral	0.04	damaging	2.46	19.22	deleterious	0.05	0.35	0.54	disease	0.93	disease	0.63	disease	0.74	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.88	deleterious	-3.53	low_impact	0.07	medium_impact	1.92	medium_impact	0.57	0.8	21.58	36.37	0.24	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15764	15764	G	T	MI.10495	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1018	340	G	W	Gga/Tga	-2.12	0	0	probably_damaging	1	neutral	0.19	neutral	3.04	deleterious	-3.94	deleterious	-3.9	high_impact	4.41	0.84	neutral	0.05	damaging	2.98	22.20	deleterious	0.05	0.35	0.88	disease	0.93	disease	0.63	disease	0.78	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.12	medium_impact	2.81	high_impact	0.12	0.8	21.58	36.37	0.4	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15765	15765	G	C	MI.10496	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1019	340	G	A	gGa/gCa	3.38	1	0	probably_damaging	1	neutral	0.51	neutral	3.23	neutral	0.74	neutral	-2.24	low_impact	1.37	0.92	neutral	0.24	damaging	1.53	13.47	neutral	0.13	0.4	0.31	neutral	0.7	disease	0.25	neutral	0.46	neutral	1	1	deleterious	0.26	neutral	-2	neutral	0.78	deleterious	-3.53	low_impact	0.23	medium_impact	0.05	medium_impact	0.34	0.8	21.58	36.37	0.37	N	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15765	15765	G	T	MI.10497	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1019	340	G	V	gGa/gTa	3.38	1	0	probably_damaging	1	neutral	0.52	neutral	3.12	neutral	-0.32	deleterious	-4.06	medium_impact	2.74	0.84	neutral	0.08	damaging	2.24	17.80	deleterious	0.04	0.35	0.48	neutral	0.92	disease	0.58	disease	0.71	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.85	deleterious	-3.53	low_impact	0.24	medium_impact	1.29	medium_impact	0.12	0.8	21.58	36.37	0.31	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15765	15765	G	A	MI.10498	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1019	340	G	E	gGa/gAa	3.38	1	0	probably_damaging	1	neutral	0.28	neutral	3.07	neutral	0.34	deleterious	-3.42	high_impact	3.86	0.82	neutral	0.07	damaging	2.38	18.70	deleterious	0.06	0.35	0.46	neutral	0.92	disease	0.62	disease	0.73	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0	medium_impact	2.31	high_impact	0.23	0.8	21.58	36.37	0.38	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15767	15767	C	A	MI.10499	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1021	341	Q	K	Caa/Aaa	-5.79	0	0	probably_damaging	0.98	neutral	0.92	neutral	3.16	neutral	-0.13	neutral	-1.64	low_impact	1.85	0.93	neutral	0.35	neutral	2.44	19.06	deleterious	0.24	0.45	0.41	neutral	0.88	disease	0.46	neutral	0.53	disease	1	0.98	deleterious	0.47	deleterious	-2	neutral	0.80	deleterious	-2.31	low_impact	0.8	medium_impact	0.49	medium_impact	0.20	0.8	45.79	7.95	0.19	N	0.92	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8573	8573	G	A	MI.105	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	47	16	G	D	gGc/gAc	6.14	1	0	benign	0.04	deleterious	0.04	neutral	4.6	neutral	-0.89	deleterious	-5.42	high_impact	3.67	0.92	neutral	0.34	neutral	1.71	14.49	neutral	0.17	0.65	0.8	disease	0.91	disease	0.7	disease	0.8	disease	6	0.96	neutral	0.5	deleterious	2	deleterious	0.33	neutral	0.55	medium_impact	-0.49	medium_impact	2.05	high_impact	0.57	0.9	17.26	11.64	0.54	P	0.91	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9019	9019	A	T	MI.1050	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	493	165	T	S	Act/Tct	-9.59	0	0	probably_damaging	0.99	neutral	0.34	neutral	4.26	neutral	-1.69	deleterious	-3.6	medium_impact	2	0.58	damaging	0.67	neutral	3.38	23.00	deleterious	0.44	0.65	0.69	disease	0.74	disease	0.61	disease	0.57	disease	1	0.99	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-2.65	low_impact	0.13	medium_impact	0.62	medium_impact	0.72	0.9	48.67	8.72	0.29	N	0.88	polymorphism	0.96	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15767	15767	C	G	MI.10500	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1021	341	Q	E	Caa/Gaa	-5.79	0	0	probably_damaging	0.96	neutral	1	neutral	3.05	neutral	-1.73	neutral	-1.49	medium_impact	3.1	0.92	neutral	0.44	neutral	1.60	13.83	neutral	0.33	0.5	0.42	neutral	0.87	disease	0.5	neutral	0.64	disease	3	0.96	neutral	0.52	deleterious	1	deleterious	0.79	deleterious	-2.02	low_impact	1.85	high_impact	1.62	medium_impact	0.34	0.8	45.79	7.95	0.19	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15768	15768	A	G	MI.10501	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1022	341	Q	R	cAa/cGa	1.54	0.86	0	probably_damaging	0.99	neutral	0.52	neutral	3.09	neutral	-1.03	neutral	-1.6	medium_impact	2.25	0.93	neutral	0.39	neutral	1.88	15.45	deleterious	0.26	0.45	0.44	neutral	0.89	disease	0.45	neutral	0.52	disease	0	0.99	deleterious	0.27	neutral	1	deleterious	0.82	deleterious	-2.59	low_impact	0.24	medium_impact	0.85	medium_impact	0.17	0.8	45.79	7.95	0.28	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15768	15768	A	T	MI.10502	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1022	341	Q	L	cAa/cTa	1.54	0.86	0	probably_damaging	0.98	neutral	0.32	neutral	3.16	neutral	-0.13	neutral	-2.27	medium_impact	2.33	0.94	neutral	0.38	neutral	2.16	17.26	deleterious	0.11	0.4	0.35	neutral	0.91	disease	0.51	disease	0.51	disease	0	0.98	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-2.31	low_impact	0.05	medium_impact	0.92	medium_impact	0.09	0.8	45.79	7.95	0.35	N	0.89	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15768	15768	A	C	MI.10503	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1022	341	Q	P	cAa/cCa	1.54	0.86	0	probably_damaging	1	neutral	0.28	neutral	3.04	neutral	-2.29	deleterious	-2.67	high_impact	4.05	0.91	neutral	0.29	neutral	1.76	14.73	neutral	0.08	0.35	0.66	disease	0.95	disease	0.62	disease	0.79	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0	medium_impact	2.48	high_impact	0.18	0.8	45.79	7.95	0.37	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15769	15769	A	T	MI.10504	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1023	341	Q	H	caA/caT	4.98	0.99	0.01	probably_damaging	1	neutral	0.13	neutral	3.03	neutral	-2.49	neutral	-2.25	high_impact	3.62	0.9	neutral	0.31	neutral	2.52	19.58	deleterious	0.18	0.45	0.63	disease	0.85	disease	0.66	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.23	medium_impact	2.09	high_impact	0.26	0.8	45.79	7.95	0.59	P	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15769	15769	A	C	MI.10505	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1023	341	Q	H	caA/caC	4.98	0.99	0.01	probably_damaging	1	neutral	0.13	neutral	3.03	neutral	-2.49	neutral	-2.25	high_impact	3.62	0.9	neutral	0.31	neutral	2.36	18.55	deleterious	0.18	0.45	0.63	disease	0.85	disease	0.66	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.23	medium_impact	2.09	high_impact	0.26	0.8	45.79	7.95	0.58	P	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15770	15770	C	T	MI.10506	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1024	342	P	S	Cca/Tca	0.17	0.97	0	probably_damaging	1	neutral	0.6	neutral	2.92	neutral	-2.32	deleterious	-4.68	high_impact	3.52	0.93	neutral	0.47	neutral	2.35	18.47	deleterious	0.18	0.45	0.4	neutral	0.86	disease	0.68	disease	0.72	disease	4	0.99	deleterious	0.3	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.32	medium_impact	2	high_impact	0.12	0.8	56.84	8.43	0.37	N	0.90	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15770	15770	C	A	MI.10507	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1024	342	P	T	Cca/Aca	0.17	0.97	0	probably_damaging	1	neutral	0.51	neutral	2.93	neutral	-2.04	deleterious	-4.69	high_impact	4.21	0.91	neutral	0.43	neutral	2.32	18.30	deleterious	0.14	0.4	0.37	neutral	0.86	disease	0.66	disease	0.72	disease	4	0.99	deleterious	0.26	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.23	medium_impact	2.63	high_impact	0.43	0.8	56.84	8.43	0.47	N	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15770	15770	C	G	MI.10508	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1024	342	P	A	Cca/Gca	0.17	0.97	0	probably_damaging	0.98	neutral	0.68	neutral	2.93	neutral	-2.02	deleterious	-4.67	high_impact	3.56	0.94	neutral	0.49	neutral	1.56	13.65	neutral	0.17	0.45	0.4	neutral	0.78	disease	0.63	disease	0.67	disease	3	0.97	neutral	0.35	neutral	2	deleterious	0.76	deleterious	-2.31	low_impact	0.4	medium_impact	2.04	high_impact	0.65	0.8	56.84	8.43	0.34	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15771	15771	C	T	MI.10509	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1025	342	P	L	cCa/cTa	5.44	1	0	probably_damaging	1	neutral	0.74	neutral	3.01	neutral	-1.1	deleterious	-5.86	high_impact	3.56	0.93	neutral	0.38	neutral	2.84	21.60	deleterious	0.08	0.35	0.41	neutral	0.91	disease	0.64	disease	0.71	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.47	medium_impact	2.04	high_impact	0.54	0.8	56.84	8.43	0.45	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9019	9019	A	G	MI.1051	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	493	165	T	A	Act/Gct	-9.59	0	0	probably_damaging	0.99	neutral	0.08	neutral	4.29	neutral	-1.1	deleterious	-4.49	high_impact	3.56	0.67	neutral	0.63	neutral	3.57	23.10	deleterious	0.53	0.65	0.45	neutral	0.72	disease	0.63	disease	0.65	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.74	deleterious	-2.65	low_impact	-0.31	medium_impact	1.95	medium_impact	0.68	0.9	48.67	8.72	0.41	N	0.63	polymorphism	0.88	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15771	15771	C	G	MI.10510	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1025	342	P	R	cCa/cGa	5.44	1	0	probably_damaging	1	neutral	0.48	neutral	2.9	neutral	-2.71	deleterious	-5.28	high_impact	5.11	0.93	neutral	0.35	neutral	2.09	16.78	deleterious	0.08	0.35	0.42	neutral	0.93	disease	0.73	disease	0.75	disease	5	1	deleterious	0.24	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.2	medium_impact	3.45	high_impact	0.23	0.8	56.84	8.43	0.69	P	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15771	15771	C	A	MI.10511	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1025	342	P	Q	cCa/cAa	5.44	1	0	probably_damaging	1	neutral	0.49	neutral	2.91	neutral	-2.51	deleterious	-4.69	high_impact	3.6	0.92	neutral	0.38	neutral	2.63	20.40	deleterious	0.12	0.4	0.41	neutral	0.87	disease	0.67	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.21	medium_impact	2.08	high_impact	0.32	0.8	56.84	8.43	0.52	N	0.86	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15773	15773	G	A	MI.10512	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1027	343	V	M	Gta/Ata	-3.73	0	0.01	probably_damaging	1	neutral	0.24	neutral	2.84	deleterious	-3.53	neutral	-1.72	high_impact	3.84	0.67	neutral	0.45	neutral	2.20	17.51	deleterious	0.21	0.45	0.6	disease	0.78	disease	0.6	disease	0.67	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	-0.05	medium_impact	2.29	high_impact	0.83	0.9	44.74	7.85	0.38	N	0.97	polymorphism	1	0.03	rs386829261	.	.	.	.	.	.	.	.	G15773A	LHON	+	-	Possibly synergistic	1	N	N	N	damaging
chrM	15773	15773	G	C	MI.10513	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1027	343	V	L	Gta/Cta	-3.73	0	0.01	possibly_damaging	0.87	neutral	0.68	neutral	2.93	neutral	-1.62	neutral	-1.74	high_impact	3.68	0.82	neutral	0.41	neutral	2.13	17.06	deleterious	0.17	0.45	0.42	neutral	0.79	disease	0.58	disease	0.66	disease	3	0.85	neutral	0.41	neutral	1	deleterious	0.62	deleterious	-1.5	low_impact	0.4	medium_impact	2.15	high_impact	0.41	0.8	44.74	7.85	0.24	N	0.69	polymorphism	1	0.02	rs386829261	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15773	15773	G	T	MI.10514	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1027	343	V	L	Gta/Tta	-3.73	0	0.01	possibly_damaging	0.87	neutral	0.68	neutral	2.93	neutral	-1.62	neutral	-1.74	high_impact	3.68	0.82	neutral	0.41	neutral	2.22	17.65	deleterious	0.17	0.45	0.42	neutral	0.79	disease	0.58	disease	0.66	disease	3	0.85	neutral	0.41	neutral	1	deleterious	0.62	deleterious	-1.5	low_impact	0.4	medium_impact	2.15	high_impact	0.41	0.8	44.74	7.85	0.24	N	0.69	polymorphism	1	0.02	rs386829261	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15774	15774	T	A	MI.10515	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1028	343	V	E	gTa/gAa	5.9	1	0	probably_damaging	0.99	neutral	0.36	neutral	2.84	deleterious	-3.33	deleterious	-3.49	high_impact	4.88	0.8	neutral	0.41	neutral	3.24	22.80	deleterious	0.03	0.35	0.29	neutral	0.9	disease	0.71	disease	0.75	disease	5	0.99	deleterious	0.19	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.09	medium_impact	3.24	high_impact	0.20	0.8	44.74	7.85	0.68	P	1.00	polymorphism	1	0.15	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15774	15774	T	G	MI.10516	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1028	343	V	G	gTa/gGa	5.9	1	0	probably_damaging	1	neutral	0.38	neutral	2.83	deleterious	-3.79	deleterious	-4.07	high_impact	4.18	0.81	neutral	0.47	neutral	2.30	18.18	deleterious	0.04	0.35	0.64	disease	0.79	disease	0.64	disease	0.67	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.11	medium_impact	2.6	high_impact	0.16	0.8	44.74	7.85	0.56	P	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15774	15774	T	C	MI.10517	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1028	343	V	A	gTa/gCa	5.9	1	0	probably_damaging	0.99	neutral	0.56	neutral	2.93	neutral	-1.65	neutral	-2.3	medium_impact	2.22	0.78	neutral	0.51	neutral	2.09	16.78	deleterious	0.16	0.45	0.38	neutral	0.67	disease	0.49	neutral	0.44	neutral	1	0.98	deleterious	0.29	neutral	1	deleterious	0.72	deleterious	-2.59	low_impact	0.28	medium_impact	0.82	medium_impact	0.21	0.8	44.74	7.85	0.36	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15776	15776	A	G	MI.10518	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1030	344	S	G	Agc/Ggc	-10.15	0	0	benign	0.4	neutral	0.39	neutral	3.17	neutral	0.04	neutral	-1.29	low_impact	0.84	0.93	neutral	0.58	neutral	2.09	16.81	deleterious	0.35	0.5	0.39	neutral	0.51	disease	0.4	neutral	0.46	neutral	1	0.55	neutral	0.5	deleterious	-6	neutral	0.37	neutral	-0.57	medium_impact	0.12	medium_impact	-0.43	medium_impact	0.40	0.8	22.37	48.43	0.33	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15776	15776	A	T	MI.10519	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1030	344	S	C	Agc/Tgc	-10.15	0	0	probably_damaging	0.96	neutral	0.18	neutral	3.08	deleterious	-3.75	neutral	-2.39	low_impact	1.73	0.95	neutral	0.44	neutral	1.91	15.67	deleterious	0.1	0.4	0.75	disease	0.74	disease	0.39	neutral	0.52	disease	0	0.98	neutral	0.11	neutral	-2	neutral	0.80	deleterious	-2.02	low_impact	-0.14	medium_impact	0.38	medium_impact	0.12	0.8	22.37	48.43	0.35	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9020	9020	C	T	MI.1052	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	494	165	T	I	aCt/aTt	8.69	1	0	probably_damaging	1	neutral	0.54	neutral	4.36	neutral	-0.2	deleterious	-5.43	low_impact	1.74	0.56	damaging	0.63	neutral	4.00	23.60	deleterious	0.39	0.65	0.44	neutral	0.68	disease	0.47	neutral	0.46	neutral	1	0.99	deleterious	0.27	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.33	medium_impact	0.39	medium_impact	0.71	0.9	48.67	8.72	0.45	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15776	15776	A	C	MI.10520	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1030	344	S	R	Agc/Cgc	-10.15	0	0	possibly_damaging	0.66	neutral	0.41	neutral	3.14	neutral	-0.52	neutral	-0.3	low_impact	1.18	0.95	neutral	0.53	neutral	2.33	18.37	deleterious	0.15	0.4	0.28	neutral	0.88	disease	0.49	neutral	0.75	disease	5	0.67	neutral	0.38	neutral	-3	neutral	0.60	deleterious	-1	medium_impact	0.14	medium_impact	-0.12	medium_impact	0.24	0.8	22.37	48.43	0.31	N	0.53	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15777	15777	G	T	MI.10521	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1031	344	S	I	aGc/aTc	4.98	1	0	possibly_damaging	0.89	neutral	0.46	neutral	3.09	neutral	-2.55	neutral	-1.9	medium_impact	2.08	0.94	neutral	0.67	neutral	2.59	20.10	deleterious	0.1	0.4	0.44	neutral	0.78	disease	0.41	neutral	0.64	disease	3	0.88	neutral	0.29	neutral	0	NA	0.73	deleterious	-1.58	low_impact	0.18	medium_impact	0.7	medium_impact	0.19	0.8	22.37	48.43	0.48	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15777	15777	G	A	MI.10522	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1031	344	S	N	aGc/aAc	4.98	1	0	benign	0.03	neutral	0.34	neutral	3.15	neutral	-0.33	neutral	-0.17	neutral_impact	0.58	0.9	neutral	0.79	neutral	2.13	17.05	deleterious	0.56	0.6	0.2	neutral	0.73	disease	0.3	neutral	0.54	disease	1	0.64	neutral	0.66	deleterious	-6	neutral	0.19	neutral	0.68	medium_impact	0.07	medium_impact	-0.67	medium_impact	0.29	0.8	22.37	48.43	0.52	N	0.37	polymorphism	1	0.01	rs879182710	Likely_benign	not_provided	364073	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15777	15777	G	C	MI.10523	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1031	344	S	T	aGc/aCc	4.98	1	0	benign	0.4	neutral	0.45	neutral	3.17	neutral	0.04	neutral	-0.67	neutral_impact	-0.5	0.92	neutral	0.63	neutral	1.88	15.48	deleterious	0.45	0.55	0.19	neutral	0.46	neutral	0.25	neutral	0.44	neutral	1	0.49	neutral	0.53	deleterious	-6	neutral	0.40	neutral	-0.57	medium_impact	0.18	medium_impact	-1.65	low_impact	0.34	0.8	22.37	48.43	0.48	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15779	15779	T	G	MI.10524	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1033	345	Y	D	Tac/Gac	2	0.99	0	possibly_damaging	0.86	neutral	0.22	neutral	3	neutral	-0.02	neutral	-1.19	neutral_impact	-0.02	0.94	neutral	0.42	neutral	1.28	12.17	neutral	0.1	0.4	0.16	neutral	0.5	neutral	0.28	neutral	0.4	neutral	2	0.91	neutral	0.18	neutral	-3	neutral	0.63	deleterious	-1.47	low_impact	-0.08	medium_impact	-1.21	low_impact	0.23	0.8	23.95	30.35	0.43	N	0.64	disease_causing	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15779	15779	T	C	MI.10525	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1033	345	Y	H	Tac/Cac	2	0.99	0	benign	0.05	neutral	0.55	neutral	2.95	neutral	-1.35	neutral	1.74	neutral_impact	-0.18	0.94	neutral	0.98	neutral	-0.63	0.11	neutral	0.24	0.45	0.16	neutral	0.07	neutral	0.19	neutral	0.28	neutral	4	0.39	neutral	0.75	deleterious	-6	neutral	0.11	neutral	0.46	medium_impact	0.27	medium_impact	-1.36	low_impact	0.23	0.8	23.95	30.35	0.43	N	0.04	polymorphism	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15779	15779	T	A	MI.10526	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1033	345	Y	N	Tac/Aac	2	0.99	0	possibly_damaging	0.76	neutral	0.32	neutral	2.98	neutral	-0.28	neutral	-0.68	low_impact	1.21	0.92	neutral	0.84	neutral	1.39	12.73	neutral	0.12	0.4	0.19	neutral	0.65	disease	0.31	neutral	0.44	neutral	1	0.8	neutral	0.28	neutral	-3	neutral	0.53	deleterious	-1.2	low_impact	0.05	medium_impact	-0.1	medium_impact	0.23	0.8	23.95	30.35	0.47	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15780	15780	A	G	MI.10527	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1034	345	Y	C	tAc/tGc	0.17	0.98	0	probably_damaging	0.98	neutral	0.18	neutral	2.92	deleterious	-3.27	neutral	-2.41	medium_impact	3.35	0.93	neutral	0.38	neutral	2.54	19.75	deleterious	0.11	0.4	0.28	neutral	0.78	disease	0.33	neutral	0.6	disease	2	0.99	deleterious	0.1	neutral	1	deleterious	0.69	deleterious	-2.31	low_impact	-0.14	medium_impact	1.85	medium_impact	0.08	0.8	23.95	30.35	0.5	N	0.67	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15780	15780	A	T	MI.10528	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1034	345	Y	F	tAc/tTc	0.17	0.98	0	possibly_damaging	0.68	neutral	0.71	neutral	2.94	neutral	-1.86	neutral	-1.45	medium_impact	2	0.93	neutral	0.6	neutral	2.43	19.02	deleterious	0.27	0.45	0.48	neutral	0.61	disease	0.35	neutral	0.49	neutral	0	0.62	neutral	0.52	deleterious	0	NA	0.61	deleterious	-1.04	low_impact	0.43	medium_impact	0.62	medium_impact	0.19	0.8	23.95	30.35	0.33	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15780	15780	A	C	MI.10529	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1034	345	Y	S	tAc/tCc	0.17	0.98	0	possibly_damaging	0.82	neutral	0.43	neutral	3.02	neutral	0.32	neutral	-1.25	low_impact	1.32	0.94	neutral	0.75	neutral	2.64	20.40	deleterious	0.1	0.4	0.16	neutral	0.57	disease	0.3	neutral	0.42	neutral	2	0.81	neutral	0.31	neutral	-3	neutral	0.58	deleterious	-1.35	low_impact	0.16	medium_impact	0.01	medium_impact	0.15	0.8	23.95	30.35	0.36	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9020	9020	C	G	MI.1053	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	494	165	T	S	aCt/aGt	8.69	1	0	probably_damaging	0.99	neutral	0.34	neutral	4.26	neutral	-1.69	deleterious	-3.6	medium_impact	2	0.58	damaging	0.67	neutral	3.59	23.20	deleterious	0.44	0.65	0.69	disease	0.74	disease	0.61	disease	0.57	disease	1	0.99	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-2.65	low_impact	0.13	medium_impact	0.62	medium_impact	0.72	0.9	48.67	8.72	0.51	P	0.88	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15782	15782	C	A	MI.10530	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1036	346	P	T	Cct/Act	-0.29	0.67	0	probably_damaging	1	neutral	0.72	neutral	2.84	neutral	-2.63	deleterious	-4.7	medium_impact	3.11	0.82	neutral	0.08	damaging	2.34	18.43	deleterious	0.08	0.35	0.45	neutral	0.86	disease	0.67	disease	0.72	disease	4	1	deleterious	0.36	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.44	medium_impact	1.63	medium_impact	0.40	0.8	55	8.32	0.2	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15782	15782	C	T	MI.10531	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1036	346	P	S	Cct/Tct	-0.29	0.67	0	probably_damaging	1	neutral	0.81	neutral	2.83	neutral	-2.81	deleterious	-4.7	high_impact	4.35	0.84	neutral	0.07	damaging	2.33	18.38	deleterious	0.08	0.35	0.36	neutral	0.86	disease	0.72	disease	0.73	disease	5	1	deleterious	0.41	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.56	medium_impact	2.76	high_impact	0.08	0.8	55	8.32	0.33	N	0.90	polymorphism	1	0.09	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15782	15782	C	G	MI.10532	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1036	346	P	A	Cct/Gct	-0.29	0.67	0	probably_damaging	0.99	neutral	0.93	neutral	2.87	neutral	-2.2	deleterious	-4.7	high_impact	3.66	0.87	neutral	0.11	damaging	1.56	13.61	neutral	0.1	0.4	0.4	neutral	0.77	disease	0.71	disease	0.71	disease	4	0.99	deleterious	0.47	deleterious	2	deleterious	0.78	deleterious	-2.59	low_impact	0.83	medium_impact	2.13	high_impact	0.64	0.8	55	8.32	0.26	N	0.84	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15783	15783	C	G	MI.10533	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1037	346	P	R	cCt/cGt	4.29	1	0	probably_damaging	1	neutral	0.64	neutral	2.82	deleterious	-3.16	deleterious	-5.29	high_impact	4.5	0.82	neutral	0.05	damaging	2.14	17.13	deleterious	0.04	0.35	0.45	neutral	0.91	disease	0.8	disease	0.78	disease	6	1	deleterious	0.32	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.36	medium_impact	2.89	high_impact	0.23	0.8	55	8.32	0.51	N	0.80	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15783	15783	C	T	MI.10534	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1037	346	P	L	cCt/cTt	4.29	1	0	probably_damaging	1	neutral	0.81	neutral	2.89	neutral	-1.85	deleterious	-5.88	medium_impact	3.29	0.85	neutral	0.05	damaging	2.82	21.50	deleterious	0.05	0.35	0.49	neutral	0.88	disease	0.69	disease	0.72	disease	4	1	deleterious	0.41	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.56	medium_impact	1.79	medium_impact	0.67	0.85	55	8.32	0.35	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15783	15783	C	A	MI.10535	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1037	346	P	H	cCt/cAt	4.29	1	0	probably_damaging	1	neutral	0.59	neutral	2.8	deleterious	-3.86	deleterious	-5.29	high_impact	4.7	0.84	neutral	0.07	damaging	2.51	19.51	deleterious	0.05	0.35	0.63	disease	0.88	disease	0.81	disease	0.77	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.31	medium_impact	3.07	high_impact	0.26	0.8	55	8.32	0.61	P	0.71	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15785	15785	T	C	MI.10536	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1039	347	F	L	Ttt/Ctt	-8.31	0	0	probably_damaging	1	neutral	0.65	neutral	3.07	neutral	-0.78	deleterious	-2.8	medium_impact	2.71	0.97	neutral	0.24	damaging	2.47	19.29	deleterious	0.18	0.45	0.45	neutral	0.73	disease	0.45	neutral	0.48	neutral	0	1	deleterious	0.33	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.37	medium_impact	1.27	medium_impact	0.65	0.8	15.79	14.55	0.23	N	0.12	polymorphism	1	0.03	rs879052837	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15785	15785	T	A	MI.10537	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1039	347	F	I	Ttt/Att	-8.31	0	0	probably_damaging	1	neutral	0.4	neutral	3.03	neutral	-1.37	deleterious	-2.86	medium_impact	3.48	0.94	neutral	0.16	damaging	2.89	21.80	deleterious	0.11	0.4	0.63	disease	0.79	disease	0.59	disease	0.67	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.81	deleterious	-3.53	low_impact	0.13	medium_impact	1.97	medium_impact	0.35	0.8	15.79	14.55	0.29	N	0.68	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15785	15785	T	G	MI.10538	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1039	347	F	V	Ttt/Gtt	-8.31	0	0	probably_damaging	1	neutral	0.5	neutral	3.02	neutral	-1.42	deleterious	-3.28	high_impact	3.68	0.95	neutral	0.16	damaging	2.60	20.20	deleterious	0.06	0.35	0.59	disease	0.88	disease	0.69	disease	0.74	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.22	medium_impact	2.15	high_impact	0.17	0.8	15.79	14.55	0.32	N	0.76	polymorphism	1	0.04	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15786	15786	T	G	MI.10539	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1040	347	F	C	tTt/tGt	5.67	0.87	0	probably_damaging	1	neutral	0.18	neutral	2.95	deleterious	-3.95	deleterious	-3.9	high_impact	4.24	0.94	neutral	0.13	damaging	2.58	19.96	deleterious	0.03	0.35	0.87	disease	0.87	disease	0.61	disease	0.78	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.14	medium_impact	2.66	high_impact	0.12	0.8	15.79	14.55	0.51	N	0.86	polymorphism	1	0.14	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9020	9020	C	A	MI.1054	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	494	165	T	N	aCt/aAt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	4.23	neutral	-2.94	deleterious	-4.54	high_impact	4.1	0.56	damaging	0.53	neutral	3.67	23.30	deleterious	0.36	0.65	0.82	disease	0.86	disease	0.66	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	2.42	high_impact	0.75	0.9	48.67	8.72	0.5	P	0.90	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15786	15786	T	A	MI.10540	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1040	347	F	Y	tTt/tAt	5.67	0.87	0	probably_damaging	1	neutral	1	neutral	3.17	neutral	0.02	neutral	-0.55	neutral_impact	0.43	0.98	neutral	0.91	neutral	0.77	9.29	deleterious	0.15	0.4	0.32	neutral	0.25	neutral	0.22	neutral	0.44	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.72	deleterious	-3.53	low_impact	1.85	high_impact	-0.8	medium_impact	0.56	0.8	15.79	14.55	0.44	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15786	15786	T	C	MI.10541	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1040	347	F	S	tTt/tCt	5.67	0.87	0	probably_damaging	1	neutral	0.4	neutral	2.98	neutral	-2.25	deleterious	-3.92	high_impact	4.24	0.93	neutral	0.13	damaging	2.68	20.70	deleterious	0.02	0.35	0.65	disease	0.85	disease	0.7	disease	0.76	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.13	medium_impact	2.66	high_impact	0.09	0.8	15.79	14.55	0.52	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15787	15787	T	G	MI.10542	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1041	347	F	L	ttT/ttG	-0.06	0.01	0.01	probably_damaging	1	neutral	0.65	neutral	3.07	neutral	-0.78	deleterious	-2.8	medium_impact	2.71	0.97	neutral	0.24	damaging	2.72	20.90	deleterious	0.18	0.45	0.45	neutral	0.73	disease	0.45	neutral	0.48	neutral	0	1	deleterious	0.33	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.37	medium_impact	1.27	medium_impact	0.65	0.8	15.79	14.55	0.24	N	0.12	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15787	15787	T	A	MI.10543	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1041	347	F	L	ttT/ttA	-0.06	0.01	0.01	probably_damaging	1	neutral	0.65	neutral	3.07	neutral	-0.78	deleterious	-2.8	medium_impact	2.71	0.97	neutral	0.24	damaging	2.86	21.70	deleterious	0.18	0.45	0.45	neutral	0.73	disease	0.45	neutral	0.48	neutral	0	1	deleterious	0.33	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.37	medium_impact	1.27	medium_impact	0.65	0.8	15.79	14.55	0.25	N	0.12	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15788	15788	A	G	MI.10544	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1042	348	T	A	Acc/Gcc	-2.35	0	0	benign	0.12	neutral	0.48	neutral	3.12	neutral	-0.65	neutral	-0.4	medium_impact	2.01	0.94	neutral	0.75	neutral	2.00	16.22	deleterious	0.23	0.45	0.29	neutral	0.48	neutral	0.51	disease	0.5	disease	0	0.44	neutral	0.68	deleterious	-3	neutral	0.16	neutral	0.08	medium_impact	0.2	medium_impact	0.63	medium_impact	0.35	0.8	17.37	14.81	0.32	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15788	15788	A	C	MI.10545	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1042	348	T	P	Acc/Ccc	-2.35	0	0	possibly_damaging	0.71	neutral	0.26	neutral	3.07	neutral	-1.97	neutral	-1.48	medium_impact	2.73	0.94	neutral	0.45	neutral	1.99	16.12	deleterious	0.04	0.35	0.61	disease	0.84	disease	0.65	disease	0.8	disease	6	0.8	neutral	0.28	neutral	0	NA	0.56	deleterious	-1.09	low_impact	-0.02	medium_impact	1.29	medium_impact	0.34	0.8	17.37	14.81	0.32	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15788	15788	A	T	MI.10546	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1042	348	T	S	Acc/Tcc	-2.35	0	0	benign	0.37	neutral	0.36	neutral	3.12	neutral	-0.79	neutral	-0.85	low_impact	1.51	0.94	neutral	0.63	neutral	1.80	14.97	neutral	0.31	0.45	0.28	neutral	0.53	disease	0.47	neutral	0.5	neutral	0	0.58	neutral	0.5	deleterious	-6	neutral	0.24	neutral	-0.52	medium_impact	0.09	medium_impact	0.18	medium_impact	0.68	0.85	17.37	14.81	0.35	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15789	15789	C	G	MI.10547	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1043	348	T	S	aCc/aGc	2.46	0.87	0	benign	0.37	neutral	0.36	neutral	3.12	neutral	-0.79	neutral	-0.85	low_impact	1.51	0.94	neutral	0.63	neutral	2.02	16.32	deleterious	0.31	0.45	0.28	neutral	0.53	disease	0.47	neutral	0.5	neutral	0	0.58	neutral	0.5	deleterious	-6	neutral	0.24	neutral	-0.52	medium_impact	0.09	medium_impact	0.18	medium_impact	0.68	0.85	17.37	14.81	0.36	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15789	15789	C	T	MI.10548	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1043	348	T	I	aCc/aTc	2.46	0.87	0	benign	0.01	neutral	0.55	neutral	3.31	neutral	1.14	neutral	1.92	neutral_impact	-1.16	0.95	neutral	0.96	neutral	-0.26	0.82	neutral	0.12	0.4	0.16	neutral	0.1	neutral	0.17	neutral	0.28	neutral	4	0.44	neutral	0.77	deleterious	-6	neutral	0.08	neutral	1.13	medium_impact	0.27	medium_impact	-2.25	low_impact	0.68	0.85	17.37	14.81	0.3	N	0.03	polymorphism	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15789	15789	C	A	MI.10549	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1043	348	T	N	aCc/aAc	2.46	0.87	0	possibly_damaging	0.59	neutral	0.25	neutral	3.09	neutral	-1.53	neutral	-1.44	low_impact	1.69	0.91	neutral	0.66	neutral	2.13	17.08	deleterious	0.24	0.45	0.31	neutral	0.74	disease	0.52	disease	0.61	disease	2	0.75	neutral	0.33	neutral	-3	neutral	0.42	neutral	-0.88	medium_impact	-0.04	medium_impact	0.34	medium_impact	0.54	0.8	17.37	14.81	0.38	N	0.38	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9022	9022	G	A	MI.1055	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	496	166	A	T	Gca/Aca	-7.74	0	0	probably_damaging	1	deleterious	0.02	neutral	3.3	deleterious	-5.88	deleterious	-3.54	high_impact	3.74	0.57	damaging	0.46	neutral	4.27	24.00	deleterious	0.31	0.65	0.9	disease	0.88	disease	0.7	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-0.66	medium_impact	2.11	high_impact	0.71	0.9	49.56	8.89	0.32	N	0.80	disease_causing	0.99	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15791	15791	A	G	MI.10550	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1045	349	I	V	Atc/Gtc	-4.87	0	0	benign	0.01	neutral	0.51	neutral	3.11	neutral	-0.15	neutral	-0.24	low_impact	1.49	0.97	neutral	0.87	neutral	0.48	7.31	deleterious	0.44	0.55	0.27	neutral	0.41	neutral	0.42	neutral	0.44	neutral	1	0.48	neutral	0.75	deleterious	-6	neutral	0.12	neutral	1.13	medium_impact	0.23	medium_impact	0.16	medium_impact	0.33	0.8	20	24.59	0.3	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15791	15791	A	C	MI.10551	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1045	349	I	L	Atc/Ctc	-4.87	0	0	benign	0.03	neutral	0.63	neutral	3.23	neutral	0.28	neutral	-0.56	neutral_impact	0.78	0.96	neutral	0.79	neutral	1.08	11.09	neutral	0.22	0.45	0.24	neutral	0.46	neutral	0.3	neutral	0.45	neutral	1	0.33	neutral	0.8	deleterious	-6	neutral	0.14	neutral	0.68	medium_impact	0.35	medium_impact	-0.49	medium_impact	0.69	0.85	20	24.59	0.3	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15791	15791	A	T	MI.10552	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1045	349	I	F	Atc/Ttc	-4.87	0	0	benign	0.23	neutral	0.62	neutral	3.09	neutral	-1.11	neutral	-1.62	low_impact	1.75	0.97	neutral	0.47	neutral	2.42	18.96	deleterious	0.19	0.45	0.44	neutral	0.8	disease	0.42	neutral	0.54	disease	1	0.27	neutral	0.7	deleterious	-6	neutral	0.27	neutral	-0.24	medium_impact	0.34	medium_impact	0.4	medium_impact	0.68	0.85	20	24.59	0.21	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15792	15792	T	C	MI.10553	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1046	349	I	T	aTc/aCc	1.54	0	0	benign	0	neutral	0.34	neutral	3.13	neutral	-0.64	neutral	-1.33	neutral_impact	0.66	0.99	neutral	0.93	neutral	0.36	6.30	deleterious	0.11	0.4	0.28	neutral	0.55	disease	0.41	neutral	0.44	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	0.07	medium_impact	-0.59	medium_impact	0.30	0.8	20	24.59	0.42	N	0.03	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15792	15792	T	G	MI.10554	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1046	349	I	S	aTc/aGc	1.54	0	0	benign	0.06	neutral	0.32	neutral	3.08	neutral	-1.2	neutral	-2.09	low_impact	1.91	0.97	neutral	0.6	neutral	2.78	21.20	deleterious	0.03	0.35	0.58	disease	0.85	disease	0.57	disease	0.65	disease	3	0.65	neutral	0.63	deleterious	-6	neutral	0.27	neutral	0.38	medium_impact	0.05	medium_impact	0.54	medium_impact	0.31	0.8	20	24.59	0.31	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15792	15792	T	A	MI.10555	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1046	349	I	N	aTc/aAc	1.54	0	0	benign	0.13	neutral	0.21	neutral	3.05	neutral	-2.26	deleterious	-2.63	medium_impact	2.49	0.93	neutral	0.45	neutral	2.92	21.90	deleterious	0.08	0.35	0.74	disease	0.85	disease	0.57	disease	0.69	disease	4	0.76	neutral	0.54	deleterious	-3	neutral	0.31	neutral	0.04	medium_impact	-0.09	medium_impact	1.07	medium_impact	0.20	0.8	20	24.59	0.35	N	0.62	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15793	15793	C	G	MI.10556	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1047	349	I	M	atC/atG	0.17	0	0.01	possibly_damaging	0.45	neutral	0.24	neutral	3.07	neutral	-1.35	neutral	-0.94	low_impact	1.46	0.95	neutral	0.85	neutral	0.73	9.03	deleterious	0.27	0.45	0.54	disease	0.47	neutral	0.39	neutral	0.59	disease	2	0.73	neutral	0.4	neutral	-3	neutral	0.25	neutral	-0.65	medium_impact	-0.05	medium_impact	0.13	medium_impact	0.69	0.85	20	24.59	0.42	N	0.68	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15793	15793	C	A	MI.10557	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1047	349	I	M	atC/atA	0.17	0	0.01	possibly_damaging	0.45	neutral	0.24	neutral	3.07	neutral	-1.35	neutral	-0.94	low_impact	1.46	0.95	neutral	0.85	neutral	1.26	12.04	neutral	0.27	0.45	0.54	disease	0.47	neutral	0.39	neutral	0.59	disease	2	0.73	neutral	0.4	neutral	-3	neutral	0.25	neutral	-0.65	medium_impact	-0.05	medium_impact	0.13	medium_impact	0.69	0.85	20	24.59	0.42	N	0.68	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15794	15794	A	T	MI.10558	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1048	350	I	F	Att/Ttt	-7.62	0	0	probably_damaging	1	neutral	0.85	neutral	2.89	neutral	-1.09	neutral	-2.16	medium_impact	3.29	0.95	neutral	0.37	neutral	2.23	17.68	deleterious	0.11	0.4	0.49	neutral	0.89	disease	0.77	disease	0.79	disease	6	1	deleterious	0.43	neutral	1	deleterious	0.81	deleterious	-3.53	low_impact	0.63	medium_impact	1.79	medium_impact	0.57	0.8	42.11	12.09	0.3	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15794	15794	A	C	MI.10559	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1048	350	I	L	Att/Ctt	-7.62	0	0	probably_damaging	0.97	neutral	0.85	neutral	3.06	neutral	0.39	neutral	-1.03	low_impact	1.66	0.94	neutral	0.35	neutral	2.31	18.22	deleterious	0.31	0.45	0.24	neutral	0.69	disease	0.52	disease	0.47	neutral	1	0.97	neutral	0.44	neutral	-2	neutral	0.56	deleterious	-2.14	low_impact	0.63	medium_impact	0.31	medium_impact	0.65	0.8	42.11	12.09	0.22	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9022	9022	G	T	MI.1056	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	496	166	A	S	Gca/Tca	-7.74	0	0	probably_damaging	0.99	neutral	0.09	neutral	3.45	deleterious	-3.49	deleterious	-2.65	medium_impact	2.56	0.53	damaging	0.58	neutral	3.78	23.40	deleterious	0.24	0.65	0.74	disease	0.88	disease	0.64	disease	0.67	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.87	deleterious	-2.65	low_impact	-0.28	medium_impact	1.1	medium_impact	0.76	0.9	49.56	8.89	0.32	N	0.95	disease_causing	0.98	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15794	15794	A	G	MI.10560	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1048	350	I	V	Att/Gtt	-7.62	0	0	probably_damaging	0.93	neutral	0.52	neutral	3	neutral	0	neutral	-0.51	medium_impact	2.06	0.98	neutral	0.65	neutral	1.52	13.43	neutral	0.5	0.6	0.27	neutral	0.56	disease	0.58	disease	0.44	neutral	1	0.92	neutral	0.3	neutral	1	deleterious	0.55	deleterious	-1.78	low_impact	0.24	medium_impact	0.68	medium_impact	0.59	0.8	42.11	12.09	0.34	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15795	15795	T	G	MI.10561	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1049	350	I	S	aTt/aGt	6.81	1	0	probably_damaging	1	neutral	0.39	neutral	2.84	neutral	-1.93	deleterious	-3.19	high_impact	4.09	0.94	neutral	0.39	neutral	2.75	21.10	deleterious	0.03	0.35	0.48	neutral	0.9	disease	0.76	disease	0.8	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.12	medium_impact	2.52	high_impact	0.25	0.8	42.11	12.09	0.59	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15795	15795	T	A	MI.10562	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1049	350	I	N	aTt/aAt	6.81	1	0	probably_damaging	1	neutral	0.29	neutral	2.81	deleterious	-3.14	deleterious	-3.75	high_impact	4.79	0.93	neutral	0.37	neutral	2.86	21.70	deleterious	0.07	0.35	0.66	disease	0.89	disease	0.77	disease	0.81	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.01	medium_impact	3.16	high_impact	0.38	0.8	42.11	12.09	0.76	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15795	15795	T	C	MI.10563	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1049	350	I	T	aTt/aCt	6.81	1	0	probably_damaging	1	neutral	0.44	neutral	2.86	neutral	-1.5	deleterious	-2.59	medium_impact	3.09	0.94	neutral	0.38	neutral	1.88	15.47	deleterious	0.05	0.35	0.43	neutral	0.78	disease	0.6	disease	0.54	disease	1	1	deleterious	0.22	neutral	1	deleterious	0.80	deleterious	-3.53	low_impact	0.17	medium_impact	1.61	medium_impact	0.37	0.8	42.11	12.09	0.49	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15796	15796	T	G	MI.10564	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1050	350	I	M	atT/atG	7.27	1	0	probably_damaging	1	neutral	0.26	neutral	2.85	neutral	-1.78	neutral	-1.56	medium_impact	2.72	0.92	neutral	0.62	neutral	1.85	15.31	deleterious	0.18	0.45	0.46	neutral	0.68	disease	0.58	disease	0.58	disease	2	1	deleterious	0.13	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	-0.02	medium_impact	1.28	medium_impact	0.63	0.8	42.11	12.09	0.54	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15796	15796	T	A	MI.10565	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1050	350	I	M	atT/atA	7.27	1	0	probably_damaging	1	neutral	0.26	neutral	2.85	neutral	-1.78	neutral	-1.56	medium_impact	2.72	0.92	neutral	0.62	neutral	2.10	16.85	deleterious	0.18	0.45	0.46	neutral	0.68	disease	0.58	disease	0.58	disease	2	1	deleterious	0.13	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	-0.02	medium_impact	1.28	medium_impact	0.63	0.8	42.11	12.09	0.54	N	0.83	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15797	15797	G	T	MI.10566	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1051	351	G	W	Gga/Tga	-7.4	0	0	probably_damaging	1	neutral	0.18	neutral	2.74	deleterious	-6.12	deleterious	-4.47	high_impact	4.95	0.86	neutral	0.05	damaging	2.85	21.60	deleterious	0.03	0.35	0.96	disease	0.9	disease	0.78	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.14	medium_impact	3.3	high_impact	0.09	0.8	56.84	8.48	0.68	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15797	15797	G	C	MI.10567	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1051	351	G	R	Gga/Cga	-7.4	0	0	probably_damaging	1	neutral	0.33	neutral	2.79	deleterious	-3.07	deleterious	-4.47	high_impact	4.95	0.79	neutral	0.03	damaging	2.37	18.65	deleterious	0.03	0.35	0.78	disease	0.9	disease	0.82	disease	0.8	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.06	medium_impact	3.3	high_impact	0.38	0.8	56.84	8.48	0.71	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15798	15798	G	A	MI.10568	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1052	351	G	E	gGa/gAa	4.98	1	0	probably_damaging	0.99	neutral	0.28	neutral	2.83	neutral	-2.26	deleterious	-4.45	high_impact	4.4	0.72	neutral	0.04	damaging	2.31	18.24	deleterious	0.03	0.35	0.69	disease	0.89	disease	0.82	disease	0.79	disease	6	0.99	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0	medium_impact	2.8	high_impact	0.23	0.8	56.84	8.48	0.61	P	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15798	15798	G	C	MI.10569	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1052	351	G	A	gGa/gCa	4.98	1	0	possibly_damaging	0.49	neutral	0.49	neutral	2.83	neutral	-2.3	deleterious	-3.35	medium_impact	2.25	0.86	neutral	0.07	damaging	1.55	13.55	neutral	0.04	0.35	0.53	disease	0.73	disease	0.69	disease	0.67	disease	3	0.5	neutral	0.5	deleterious	0	NA	0.64	deleterious	-0.72	medium_impact	0.21	medium_impact	0.85	medium_impact	0.34	0.8	56.84	8.48	0.41	N	0.73	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9022	9022	G	C	MI.1057	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	496	166	A	P	Gca/Cca	-7.74	0	0	probably_damaging	1	deleterious	0	neutral	3.26	deleterious	-7.36	deleterious	-4.53	high_impact	4.54	0.41	damaging	0.44	neutral	3.95	23.60	deleterious	0.13	0.65	0.96	disease	0.92	disease	0.8	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.6	low_impact	-1.4	low_impact	2.79	high_impact	0.72	0.9	49.56	8.89	0.64	P	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15798	15798	G	T	MI.10570	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1052	351	G	V	gGa/gTa	4.98	1	0	probably_damaging	1	neutral	0.52	neutral	2.75	deleterious	-4.76	deleterious	-5.03	high_impact	4.95	0.81	neutral	0.06	damaging	2.23	17.73	deleterious	0.03	0.35	0.42	neutral	0.91	disease	0.76	disease	0.76	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.24	medium_impact	3.3	high_impact	0.22	0.8	56.84	8.48	0.68	P	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15800	15800	C	G	MI.10571	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1054	352	Q	E	Caa/Gaa	-10.83	0	0	probably_damaging	0.96	neutral	0.27	neutral	2.92	neutral	-2.34	neutral	-1.66	high_impact	4.15	0.74	neutral	0.09	damaging	1.58	13.72	neutral	0.27	0.45	0.44	neutral	0.83	disease	0.76	disease	0.74	disease	5	0.96	neutral	0.16	neutral	2	deleterious	0.81	deleterious	-2.02	low_impact	-0.01	medium_impact	2.57	high_impact	0.52	0.8	57.89	8.44	0.42	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15800	15800	C	A	MI.10572	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1054	352	Q	K	Caa/Aaa	-10.83	0	0	probably_damaging	0.98	neutral	0.29	neutral	2.92	neutral	-2.38	neutral	-2.2	high_impact	3.55	0.84	neutral	0.07	damaging	2.42	18.93	deleterious	0.15	0.4	0.25	neutral	0.88	disease	0.75	disease	0.73	disease	5	0.98	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-2.31	low_impact	0.01	medium_impact	2.03	high_impact	0.51	0.8	57.89	8.44	0.35	N	1.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15801	15801	A	C	MI.10573	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1055	352	Q	P	cAa/cCa	5.44	1	0	probably_damaging	1	neutral	0.2	neutral	2.89	deleterious	-3.19	deleterious	-3.31	high_impact	4.36	0.88	neutral	0.07	damaging	1.65	14.11	neutral	0.03	0.35	0.72	disease	0.89	disease	0.79	disease	0.78	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.1	medium_impact	2.77	high_impact	0.29	0.8	57.89	8.44	0.6	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15801	15801	A	T	MI.10574	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1055	352	Q	L	cAa/cTa	5.44	1	0	probably_damaging	0.98	neutral	0.65	neutral	3.03	neutral	-0.94	deleterious	-3.87	medium_impact	3.04	0.87	neutral	0.07	damaging	2.08	16.74	deleterious	0.05	0.35	0.57	disease	0.92	disease	0.69	disease	0.73	disease	5	0.98	neutral	0.34	neutral	1	deleterious	0.84	deleterious	-2.31	low_impact	0.37	medium_impact	1.57	medium_impact	0.19	0.8	57.89	8.44	0.41	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15801	15801	A	G	MI.10575	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1055	352	Q	R	cAa/cGa	5.44	1	0	probably_damaging	0.99	neutral	0.35	neutral	2.95	neutral	-1.9	neutral	-2.18	medium_impact	2.98	0.83	neutral	0.08	damaging	1.84	15.20	deleterious	0.15	0.4	0.36	neutral	0.89	disease	0.67	disease	0.65	disease	3	0.99	deleterious	0.18	neutral	1	deleterious	0.82	deleterious	-2.59	low_impact	0.08	medium_impact	1.51	medium_impact	0.31	0.8	57.89	8.44	0.4	N	0.99	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15802	15802	A	T	MI.10576	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1056	352	Q	H	caA/caT	5.44	1	0	probably_damaging	1	neutral	0.54	neutral	2.88	deleterious	-3.51	deleterious	-2.76	high_impact	5.04	0.87	neutral	0.08	damaging	2.08	16.70	deleterious	0.13	0.4	0.65	disease	0.85	disease	0.79	disease	0.76	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.26	medium_impact	3.38	high_impact	0.59	0.8	57.89	8.44	0.75	P	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15802	15802	A	C	MI.10577	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1056	352	Q	H	caA/caC	5.44	1	0	probably_damaging	1	neutral	0.54	neutral	2.88	deleterious	-3.51	deleterious	-2.76	high_impact	5.04	0.87	neutral	0.08	damaging	1.90	15.61	deleterious	0.13	0.4	0.65	disease	0.85	disease	0.79	disease	0.76	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.26	medium_impact	3.38	high_impact	0.59	0.8	57.89	8.44	0.75	P	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15803	15803	G	T	MI.10578	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1057	353	V	L	Gta/Tta	4.52	0.98	0	benign	0.12	neutral	0.73	neutral	2.99	neutral	-0.08	neutral	-0.16	neutral_impact	-0.12	0.93	neutral	0.92	neutral	-0.57	0.15	neutral	0.23	0.45	NA	NA	0.23	neutral	0.31	neutral	0.17	neutral	7	0.16	neutral	0.81	deleterious	-6	neutral	0.15	neutral	0.08	medium_impact	0.46	medium_impact	-1.3	low_impact	0.63	0.8	26.84	28.45	0.48	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15803	15803	G	C	MI.10579	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1057	353	V	L	Gta/Cta	4.52	0.98	0	benign	0.12	neutral	0.73	neutral	2.99	neutral	-0.08	neutral	-0.16	neutral_impact	-0.12	0.93	neutral	0.92	neutral	-0.67	0.09	neutral	0.23	0.45	NA	NA	0.23	neutral	0.31	neutral	0.17	neutral	7	0.16	neutral	0.81	deleterious	-6	neutral	0.15	neutral	0.08	medium_impact	0.46	medium_impact	-1.3	low_impact	0.63	0.8	26.84	28.45	0.48	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9023	9023	C	T	MI.1058	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	497	166	A	V	gCa/gTa	7.3	1	0	probably_damaging	1	neutral	0.15	neutral	3.39	deleterious	-5.98	deleterious	-3.59	high_impact	4.2	0.44	damaging	0.42	neutral	4.49	24.30	deleterious	0.32	0.65	0.78	disease	0.91	disease	0.69	disease	0.74	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.13	medium_impact	2.5	high_impact	0.75	0.9	49.56	8.89	0.74	P	0.75	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15803	15803	G	A	MI.10580	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1057	353	V	M	Gta/Ata	4.52	0.98	0	benign	0.14	neutral	0.24	neutral	2.84	neutral	-1.85	neutral	-0.59	low_impact	1.18	0.9	neutral	0.89	neutral	1.09	11.14	neutral	0.21	0.45	NA	NA	0.34	neutral	0.39	neutral	0.15	neutral	7	0.72	neutral	0.55	deleterious	-6	neutral	0.16	neutral	0	medium_impact	-0.05	medium_impact	-0.12	medium_impact	0.61	0.8	26.84	28.45	0.62	P	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15804	15804	T	A	MI.10581	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1058	353	V	E	gTa/gAa	-7.62	0	0.01	possibly_damaging	0.79	neutral	0.27	neutral	2.8	deleterious	-3.09	deleterious	-2.58	high_impact	3.73	0.89	neutral	0.52	neutral	3.44	23.00	deleterious	0.02	0.35	NA	NA	0.82	disease	0.72	disease	0.78	disease	6	0.84	neutral	0.24	neutral	1	deleterious	0.75	deleterious	-1.27	low_impact	-0.01	medium_impact	2.19	high_impact	0.12	0.8	26.84	28.45	0.42	N	0.86	polymorphism	1	0.12	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15804	15804	T	G	MI.10582	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1058	353	V	G	gTa/gGa	-7.62	0	0.01	possibly_damaging	0.79	neutral	0.35	neutral	2.81	neutral	-2.74	deleterious	-3.04	medium_impact	2.83	0.91	neutral	0.47	neutral	2.36	18.53	deleterious	0.02	0.35	NA	NA	0.67	disease	0.64	disease	0.71	disease	4	0.81	neutral	0.28	neutral	0	NA	0.63	deleterious	-1.27	low_impact	0.08	medium_impact	1.38	medium_impact	0.26	0.8	26.84	28.45	0.34	N	0.81	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15804	15804	T	C	MI.10583	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1058	353	V	A	gTa/gCa	-7.62	0	0.01	benign	0.4	neutral	0.53	neutral	2.88	neutral	-1.17	neutral	-1.42	low_impact	1.07	0.89	neutral	0.85	neutral	0.92	10.22	neutral	0.11	0.4	NA	NA	0.32	neutral	0.43	neutral	0.15	neutral	7	0.42	neutral	0.57	deleterious	-6	neutral	0.32	neutral	-0.57	medium_impact	0.25	medium_impact	-0.22	medium_impact	0.15	0.8	26.84	28.45	0.31	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15806	15806	G	A	MI.10584	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1060	354	A	T	Gca/Aca	-1.89	0	0	benign	0.08	neutral	0.5	neutral	2.88	neutral	-1.34	neutral	-1.75	medium_impact	3.3	0.91	neutral	0.58	neutral	2.69	20.70	deleterious	0.12	0.4	NA	NA	0.85	disease	0.45	neutral	0.64	disease	3	0.44	neutral	0.71	deleterious	-3	neutral	0.31	neutral	0.26	medium_impact	0.22	medium_impact	1.8	medium_impact	0.76	0.85	53.16	7.53	0.31	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15806	15806	G	C	MI.10585	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1060	354	A	P	Gca/Cca	-1.89	0	0	probably_damaging	0.92	neutral	0.12	neutral	2.82	deleterious	-3.33	neutral	-2.45	high_impact	3.92	0.84	neutral	0.27	damaging	2.30	18.16	deleterious	0.03	0.35	NA	NA	0.91	disease	0.68	disease	0.74	disease	5	0.97	neutral	0.1	neutral	2	deleterious	0.91	deleterious	-1.72	low_impact	-0.25	medium_impact	2.37	high_impact	0.58	0.8	53.16	7.53	0.36	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15806	15806	G	T	MI.10586	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1060	354	A	S	Gca/Tca	-1.89	0	0	possibly_damaging	0.69	neutral	0.34	neutral	2.89	neutral	-1.11	neutral	-1.22	low_impact	1.82	0.91	neutral	0.6	neutral	2.10	16.84	deleterious	0.17	0.45	NA	NA	0.81	disease	0.42	neutral	0.5	neutral	0	0.74	neutral	0.33	neutral	-3	neutral	0.54	deleterious	-1.06	low_impact	0.07	medium_impact	0.46	medium_impact	0.58	0.8	53.16	7.53	0.32	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15807	15807	C	G	MI.10587	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1061	354	A	G	gCa/gGa	4.98	1	0	possibly_damaging	0.45	neutral	0.29	neutral	2.84	neutral	-2.37	neutral	-1.97	medium_impact	2.88	0.82	neutral	0.52	neutral	2.38	18.71	deleterious	0.17	0.45	NA	NA	0.85	disease	0.53	disease	0.68	disease	4	0.67	neutral	0.42	neutral	0	NA	0.53	deleterious	-0.65	medium_impact	0.01	medium_impact	1.42	medium_impact	0.68	0.85	53.16	7.53	0.5	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15807	15807	C	A	MI.10588	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1061	354	A	E	gCa/gAa	4.98	1	0	probably_damaging	0.93	neutral	0.16	neutral	2.83	neutral	-2.61	neutral	-2.4	high_impact	4.28	0.82	neutral	0.41	neutral	3.06	22.40	deleterious	0.03	0.35	NA	NA	0.93	disease	0.67	disease	0.76	disease	5	0.96	neutral	0.12	neutral	2	deleterious	0.87	deleterious	-1.78	low_impact	-0.17	medium_impact	2.69	high_impact	0.38	0.8	53.16	7.53	0.57	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15807	15807	C	T	MI.10589	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1061	354	A	V	gCa/gTa	4.98	1	0	possibly_damaging	0.57	neutral	0.51	neutral	2.94	neutral	-0.56	neutral	-1.96	medium_impact	3.12	0.84	neutral	0.51	neutral	2.90	21.90	deleterious	0.08	0.35	NA	NA	0.9	disease	0.55	disease	0.68	disease	4	0.55	neutral	0.47	deleterious	0	NA	0.74	deleterious	-0.85	medium_impact	0.23	medium_impact	1.64	medium_impact	0.70	0.85	53.16	7.53	0.51	N	0.84	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9023	9023	C	A	MI.1059	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	497	166	A	E	gCa/gAa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	3.27	deleterious	-7.62	deleterious	-4.48	high_impact	4.54	0.53	damaging	0.44	neutral	4.48	24.20	deleterious	0.09	0.65	0.98	disease	0.94	disease	0.77	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.79	high_impact	0.72	0.9	49.56	8.89	0.55	P	0.99	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15809	15809	T	A	MI.10590	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1063	355	S	T	Tcc/Acc	-3.27	0	0	probably_damaging	0.99	neutral	0.44	neutral	3.16	neutral	-0.06	neutral	-1.29	low_impact	1.29	0.87	neutral	0.08	damaging	2.30	18.17	deleterious	0.24	0.45	NA	NA	0.66	disease	0.39	neutral	0.41	neutral	2	0.99	deleterious	0.23	neutral	-2	neutral	0.82	deleterious	-2.59	low_impact	0.17	medium_impact	-0.02	medium_impact	0.66	0.8	58.16	8.54	0.22	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15809	15809	T	G	MI.10591	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1063	355	S	A	Tcc/Gcc	-3.27	0	0	probably_damaging	0.99	neutral	0.66	neutral	2.98	neutral	-1.74	neutral	-1.54	medium_impact	2.75	0.84	neutral	0.19	damaging	2.21	17.61	deleterious	0.24	0.45	NA	NA	0.64	disease	0.58	disease	0.56	disease	1	0.99	deleterious	0.34	neutral	1	deleterious	0.80	deleterious	-2.59	low_impact	0.38	medium_impact	1.3	medium_impact	0.45	0.8	58.16	8.54	0.18	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15809	15809	T	C	MI.10592	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1063	355	S	P	Tcc/Ccc	-3.27	0	0	probably_damaging	1	neutral	0.17	neutral	2.93	deleterious	-3.04	deleterious	-2.58	high_impact	4.45	0.89	neutral	0.06	damaging	2.44	19.11	deleterious	0.03	0.35	NA	NA	0.87	disease	0.74	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.15	medium_impact	2.85	high_impact	0.24	0.8	58.16	8.54	0.5	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15810	15810	C	G	MI.10593	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1064	355	S	C	tCc/tGc	7.27	1	0	probably_damaging	1	neutral	0.15	neutral	2.91	deleterious	-4.28	deleterious	-2.58	high_impact	4.8	0.86	neutral	0.05	damaging	2.00	16.21	deleterious	0.06	0.35	NA	NA	0.85	disease	0.65	disease	0.72	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.19	medium_impact	3.17	high_impact	0.35	0.8	58.16	8.54	0.66	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15810	15810	C	T	MI.10594	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1064	355	S	F	tCc/tTc	7.27	1	0	probably_damaging	1	neutral	0.98	neutral	2.95	neutral	-2.44	deleterious	-3.12	high_impact	4.8	0.9	neutral	0.07	damaging	2.62	20.30	deleterious	0.03	0.35	NA	NA	0.92	disease	0.65	disease	0.72	disease	4	1	deleterious	0.49	deleterious	2	deleterious	0.90	deleterious	-3.53	low_impact	1.14	medium_impact	3.17	high_impact	0.12	0.8	58.16	8.54	0.65	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15810	15810	C	A	MI.10595	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1064	355	S	Y	tCc/tAc	7.27	1	0	probably_damaging	1	neutral	0.98	neutral	2.95	neutral	-2.46	deleterious	-3.12	high_impact	4.8	0.9	neutral	0.06	damaging	2.58	19.99	deleterious	0.04	0.35	NA	NA	0.9	disease	0.69	disease	0.74	disease	5	1	deleterious	0.49	deleterious	2	deleterious	0.88	deleterious	-3.53	low_impact	1.14	medium_impact	3.17	high_impact	0.26	0.8	58.16	8.54	0.66	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15812	15812	G	T	MI.10596	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1066	356	V	L	Gta/Tta	-7.85	0	0.01	benign	0	neutral	1	neutral	2.97	neutral	-0.07	neutral	-0.52	neutral_impact	0.32	0.86	neutral	0.71	neutral	0.99	10.60	neutral	0.19	0.45	NA	NA	0.47	neutral	0.39	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	1.85	high_impact	-0.9	medium_impact	0.67	0.85	21.32	33.53	0.23	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15812	15812	G	C	MI.10597	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1066	356	V	L	Gta/Cta	-7.85	0	0.01	benign	0	neutral	1	neutral	2.97	neutral	-0.07	neutral	-0.52	neutral_impact	0.32	0.86	neutral	0.71	neutral	0.88	9.95	deleterious	0.19	0.45	NA	NA	0.47	neutral	0.39	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	1.85	high_impact	-0.9	medium_impact	0.67	0.85	21.32	33.53	0.22	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15812	15812	G	A	MI.10598	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1066	356	V	M	Gta/Ata	-7.85	0	0.01	benign	0.03	neutral	0.24	neutral	2.81	neutral	-2.12	neutral	-0.73	low_impact	1.57	0.51	damaging	0.86	neutral	1.07	11.06	neutral	0.21	0.45	NA	NA	0.46	neutral	0.44	neutral	0.23	neutral	6	0.75	neutral	0.61	deleterious	-6	neutral	0.14	neutral	0.68	medium_impact	-0.05	medium_impact	0.23	medium_impact	0.70	0.85	21.32	33.53	0.55	P	0.04	disease_causing_automatic	0	0.02	rs200336777	Pathogenic	Leber's_optic_atrophy	24714	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	CPD	6.69	G15812A	LHON	+	-	Reported / Secondary	19	P	N	P,N	neutral
chrM	15813	15813	T	C	MI.10599	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1067	356	V	A	gTa/gCa	-0.52	0	0.02	benign	0.01	neutral	0.5	neutral	2.94	neutral	-0.73	neutral	-1.23	low_impact	1.1	0.87	neutral	0.8	neutral	0.88	9.97	deleterious	0.14	0.4	NA	NA	0.34	neutral	0.45	neutral	0.15	neutral	7	0.48	neutral	0.75	deleterious	-6	neutral	0.14	neutral	1.13	medium_impact	0.22	medium_impact	-0.2	medium_impact	0.17	0.8	21.32	33.53	0.32	N	0.43	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8575	8575	C	G	MI.106	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	49	17	L	V	Cta/Gta	-11.44	0	0	probably_damaging	0.99	neutral	0.18	neutral	4.55	neutral	-1.15	neutral	-0.28	neutral_impact	0.56	0.91	neutral	0.95	neutral	1.83	15.18	deleterious	0.5	0.65	0.52	disease	0.36	neutral	0.32	neutral	0.36	neutral	3	0.99	deleterious	0.1	neutral	-2	neutral	0.71	deleterious	-2.65	low_impact	-0.08	medium_impact	-0.62	medium_impact	0.71	0.9	28.76	21.22	0.48	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9023	9023	C	G	MI.1060	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	497	166	A	G	gCa/gGa	7.3	1	0	probably_damaging	0.99	deleterious	0	neutral	3.29	deleterious	-3.88	deleterious	-3.59	medium_impact	3.39	0.56	damaging	0.55	neutral	4.00	23.60	deleterious	0.2	0.65	0.84	disease	0.87	disease	0.62	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.86	deleterious	-2.65	low_impact	-1.4	low_impact	1.81	medium_impact	0.80	0.9	49.56	8.89	0.49	N	0.86	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15813	15813	T	A	MI.10600	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1067	356	V	E	gTa/gAa	-0.52	0	0.02	benign	0.21	neutral	0.23	neutral	2.78	deleterious	-3.24	neutral	-2.32	high_impact	3.87	0.89	neutral	0.5	neutral	3.10	22.50	deleterious	0.02	0.35	NA	NA	0.87	disease	0.74	disease	0.81	disease	6	0.73	neutral	0.51	deleterious	-2	neutral	0.36	neutral	-0.19	medium_impact	-0.06	medium_impact	2.32	high_impact	0.17	0.8	21.32	33.53	0.45	N	0.73	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15813	15813	T	G	MI.10601	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1067	356	V	G	gTa/gGa	-0.52	0	0.02	benign	0.3	neutral	0.4	neutral	2.79	deleterious	-3.04	deleterious	-2.72	medium_impact	2.62	0.87	neutral	0.46	neutral	2.29	18.13	deleterious	0.04	0.35	NA	NA	0.71	disease	0.63	disease	0.69	disease	4	0.52	neutral	0.55	deleterious	-3	neutral	0.36	neutral	-0.39	medium_impact	0.13	medium_impact	1.19	medium_impact	0.26	0.8	21.32	33.53	0.27	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15815	15815	C	G	MI.10602	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1069	357	L	V	Cta/Gta	-6.48	0	0	probably_damaging	0.98	neutral	0.46	neutral	2.88	neutral	-0.79	neutral	-0.88	medium_impact	2.08	0.96	neutral	0.66	neutral	1.80	14.99	neutral	0.33	0.5	NA	NA	0.64	disease	0.41	neutral	0.48	neutral	0	0.98	neutral	0.24	neutral	1	deleterious	0.80	deleterious	-2.31	low_impact	0.18	medium_impact	0.7	medium_impact	0.69	0.85	18.68	21.01	0.31	N	0.39	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15815	15815	C	A	MI.10603	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1069	357	L	M	Cta/Ata	-6.48	0	0	probably_damaging	1	neutral	0.19	neutral	2.81	neutral	-1.59	neutral	-0.59	low_impact	1.93	0.95	neutral	0.91	neutral	1.02	10.80	neutral	0.3	0.45	NA	NA	0.47	neutral	0.36	neutral	0.27	neutral	5	1	deleterious	0.1	neutral	-2	neutral	0.76	deleterious	-3.53	low_impact	-0.12	medium_impact	0.56	medium_impact	0.49	0.8	18.68	21.01	0.43	N	0.06	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15816	15816	T	A	MI.10604	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1070	357	L	Q	cTa/cAa	-11.06	0	0	probably_damaging	1	neutral	0.2	neutral	2.74	deleterious	-3.46	neutral	-2.17	high_impact	3.95	0.94	neutral	0.48	neutral	2.70	20.80	deleterious	0.03	0.35	NA	NA	0.78	disease	0.58	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.1	medium_impact	2.39	high_impact	0.21	0.8	18.68	21.01	0.42	N	0.56	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15816	15816	T	C	MI.10605	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1070	357	L	P	cTa/cCa	-11.06	0	0	probably_damaging	1	neutral	0.13	neutral	2.73	deleterious	-3.92	deleterious	-2.6	high_impact	4.29	0.93	neutral	0.33	neutral	2.40	18.82	deleterious	0.02	0.35	NA	NA	0.89	disease	0.7	disease	0.75	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.23	medium_impact	2.7	high_impact	0.16	0.8	18.68	21.01	0.46	N	0.95	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15816	15816	T	G	MI.10606	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1070	357	L	R	cTa/cGa	-11.06	0	0	probably_damaging	1	neutral	0.12	neutral	2.74	deleterious	-3.19	neutral	-2.25	high_impact	4.29	0.94	neutral	0.42	neutral	2.59	20.20	deleterious	0.02	0.35	NA	NA	0.91	disease	0.69	disease	0.75	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.25	medium_impact	2.7	high_impact	0.20	0.8	18.68	21.01	0.49	N	0.69	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15818	15818	T	A	MI.10607	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1072	358	Y	N	Tac/Aac	-6.71	0	0	probably_damaging	1	neutral	0.16	neutral	2.47	deleterious	-5.26	deleterious	-4.75	high_impact	5.14	0.92	neutral	0.14	damaging	2.45	19.11	deleterious	0.08	0.35	NA	NA	0.87	disease	0.72	disease	0.76	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.17	medium_impact	3.47	high_impact	0.14	0.8	57.63	8.54	0.65	P	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15818	15818	T	C	MI.10608	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1072	358	Y	H	Tac/Cac	-6.71	0	0	probably_damaging	1	neutral	0.23	neutral	2.49	deleterious	-4.33	deleterious	-2.63	high_impact	4.11	0.92	neutral	0.09	damaging	1.96	15.98	deleterious	0.17	0.45	NA	NA	0.86	disease	0.79	disease	0.74	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.06	medium_impact	2.54	high_impact	0.18	0.8	57.63	8.54	0.47	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15818	15818	T	G	MI.10609	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1072	358	Y	D	Tac/Gac	-6.71	0	0	probably_damaging	1	neutral	0.07	neutral	2.46	deleterious	-5.67	deleterious	-5.28	high_impact	5.14	0.89	neutral	0.12	damaging	2.36	18.59	deleterious	0.04	0.35	NA	NA	0.91	disease	0.8	disease	0.82	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.39	medium_impact	3.47	high_impact	0.14	0.8	57.63	8.54	0.65	P	1.00	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9025	9025	G	A	MI.1061	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	499	167	G	S	Ggc/Agc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.23	deleterious	-5.94	deleterious	-5.34	high_impact	4.08	0.55	damaging	0.5	neutral	4.26	23.90	deleterious	0.25	0.65	0.9	disease	0.88	disease	0.73	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.4	high_impact	0.65	0.9	49.12	8.62	0.3	N	0.98	disease_causing	1	0.35	rs28681063	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15819	15819	A	G	MI.10610	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1073	358	Y	C	tAc/tGc	4.52	1	0	probably_damaging	1	neutral	0.06	neutral	2.46	deleterious	-6.06	deleterious	-4.76	high_impact	5.14	0.94	neutral	0.07	damaging	1.86	15.33	deleterious	0.06	0.35	NA	NA	0.9	disease	0.78	disease	0.8	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.43	medium_impact	3.47	high_impact	0.16	0.8	57.63	8.54	0.66	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15819	15819	A	C	MI.10611	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1073	358	Y	S	tAc/tCc	4.52	1	0	probably_damaging	1	neutral	0.18	neutral	2.48	deleterious	-4.64	deleterious	-4.75	high_impact	5.14	0.92	neutral	0.11	damaging	2.09	16.77	deleterious	0.08	0.35	NA	NA	0.89	disease	0.73	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.47	high_impact	0.14	0.8	57.63	8.54	0.71	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15819	15819	A	T	MI.10612	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1073	358	Y	F	tAc/tTc	4.52	1	0	probably_damaging	1	neutral	0.86	neutral	2.6	neutral	-2.46	neutral	-2.12	medium_impact	3.23	0.94	neutral	0.11	damaging	1.74	14.66	neutral	0.26	0.45	NA	NA	0.88	disease	0.69	disease	0.73	disease	5	1	deleterious	0.43	neutral	1	deleterious	0.90	deleterious	-3.53	low_impact	0.65	medium_impact	1.74	medium_impact	0.42	0.8	57.63	8.54	0.39	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15821	15821	T	A	MI.10613	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1075	359	F	I	Ttc/Atc	-0.52	0.13	0	probably_damaging	1	neutral	0.32	neutral	1.92	deleterious	-4.75	deleterious	-3.15	high_impact	3.94	0.94	neutral	0.12	damaging	3.05	22.40	deleterious	0.07	0.35	NA	NA	0.84	disease	0.76	disease	0.77	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.05	medium_impact	2.38	high_impact	0.40	0.8	57.89	8.41	0.46	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15821	15821	T	G	MI.10614	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1075	359	F	V	Ttc/Gtc	-0.52	0.13	0	probably_damaging	1	neutral	0.26	neutral	1.91	deleterious	-4.86	deleterious	-3.67	high_impact	4.62	0.95	neutral	0.11	damaging	2.66	20.60	deleterious	0.06	0.35	NA	NA	0.89	disease	0.76	disease	0.79	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.02	medium_impact	3	high_impact	0.36	0.8	57.89	8.41	0.6	P	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15821	15821	T	C	MI.10615	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1075	359	F	L	Ttc/Ctc	-0.52	0.13	0	probably_damaging	0.99	neutral	0.65	neutral	1.97	deleterious	-3.89	deleterious	-3.15	high_impact	3.56	0.95	neutral	0.09	damaging	2.67	20.60	deleterious	0.1	0.4	NA	NA	0.82	disease	0.69	disease	0.71	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.37	medium_impact	2.04	high_impact	0.61	0.8	57.89	8.41	0.22	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15822	15822	T	G	MI.10616	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1076	359	F	C	tTc/tGc	4.52	1	0	probably_damaging	1	deleterious	0.02	neutral	1.86	deleterious	-7.7	deleterious	-4.2	high_impact	4.83	0.95	neutral	0.09	damaging	2.58	19.99	deleterious	0.03	0.35	NA	NA	0.86	disease	0.77	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.53	low_impact	-0.69	medium_impact	3.19	high_impact	0.23	0.8	57.89	8.41	0.64	P	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15822	15822	T	C	MI.10617	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1076	359	F	S	tTc/tCc	4.52	1	0	probably_damaging	1	neutral	0.18	neutral	1.88	deleterious	-6.25	deleterious	-4.2	high_impact	4.62	0.96	neutral	0.09	damaging	2.72	20.90	deleterious	0.03	0.35	NA	NA	0.87	disease	0.72	disease	0.76	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.14	medium_impact	3	high_impact	0.32	0.8	57.89	8.41	0.58	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15822	15822	T	A	MI.10618	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1076	359	F	Y	tTc/tAc	4.52	1	0	probably_damaging	0.99	neutral	0.87	neutral	2.03	deleterious	-3.26	neutral	-1.57	high_impact	4.28	0.95	neutral	0.11	damaging	2.73	21.00	deleterious	0.1	0.4	NA	NA	0.8	disease	0.72	disease	0.72	disease	4	0.99	deleterious	0.44	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0.67	medium_impact	2.69	high_impact	0.50	0.8	57.89	8.41	0.45	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15823	15823	C	A	MI.10619	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1077	359	F	L	ttC/ttA	7.27	1	0	probably_damaging	0.99	neutral	0.65	neutral	1.97	deleterious	-3.89	deleterious	-3.15	high_impact	3.56	0.95	neutral	0.09	damaging	3.11	22.50	deleterious	0.1	0.4	NA	NA	0.82	disease	0.69	disease	0.71	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.37	medium_impact	2.04	high_impact	0.61	0.8	57.89	8.41	0.45	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9025	9025	G	C	MI.1062	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	499	167	G	R	Ggc/Cgc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.19	deleterious	-7.27	deleterious	-7.17	high_impact	4.63	0.41	damaging	0.3	neutral	4.05	23.70	deleterious	0.12	0.65	0.95	disease	0.92	disease	0.82	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.59	0.9	49.12	8.62	0.67	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15823	15823	C	G	MI.10620	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1077	359	F	L	ttC/ttG	7.27	1	0	probably_damaging	0.99	neutral	0.65	neutral	1.97	deleterious	-3.89	deleterious	-3.15	high_impact	3.56	0.95	neutral	0.09	damaging	2.80	21.40	deleterious	0.1	0.4	NA	NA	0.82	disease	0.69	disease	0.71	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.37	medium_impact	2.04	high_impact	0.61	0.8	57.89	8.41	0.45	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15824	15824	A	C	MI.10621	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1078	360	T	P	Aca/Cca	-0.52	0	0	benign	0.2	neutral	0.13	neutral	3.11	neutral	-2.05	neutral	-1.52	medium_impact	3.1	0.94	neutral	0.39	neutral	0.61	8.24	deleterious	0.06	0.35	NA	NA	0.84	disease	0.55	disease	0.78	disease	6	0.85	neutral	0.47	neutral	-3	neutral	0.44	deleterious	-0.17	medium_impact	-0.23	medium_impact	1.62	medium_impact	0.41	0.8	16.58	21.58	0.35	N	0.73	polymorphism	1	0.03	rs28357376	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15824	15824	A	T	MI.10622	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1078	360	T	S	Aca/Tca	-0.52	0	0	benign	0.02	neutral	0.31	neutral	3.21	neutral	0.07	neutral	-0.34	neutral_impact	-0.07	0.98	neutral	0.98	neutral	-0.76	0.05	neutral	0.24	0.45	NA	NA	0.13	neutral	0.24	neutral	0.19	neutral	6	0.68	neutral	0.65	deleterious	-6	neutral	0.09	neutral	0.85	medium_impact	0.03	medium_impact	-1.26	low_impact	0.59	0.8	16.58	21.58	0.47	N	0.00	polymorphism	1	0.01	rs28357376	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15824	15824	A	G	MI.10623	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1078	360	T	A	Aca/Gca	-0.52	0	0	benign	0	neutral	0.32	neutral	3.22	neutral	1.3	neutral	-0.37	neutral_impact	0.1	0.96	neutral	0.85	neutral	-0.09	1.80	neutral	0.17	0.45	NA	NA	0.27	neutral	0.3	neutral	0.17	neutral	7	0.68	neutral	0.66	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.05	medium_impact	-1.1	low_impact	0.44	0.8	16.58	21.58	0.34	N	0.16	polymorphism	1	0.01	rs28357376	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15825	15825	C	A	MI.10624	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1079	360	T	K	aCa/aAa	-3.73	0	0	benign	0.04	neutral	0.07	neutral	3.12	neutral	-0.92	neutral	-1.28	medium_impact	3.1	0.94	neutral	0.49	neutral	1.45	13.03	neutral	0.08	0.35	NA	NA	0.75	disease	0.53	disease	0.67	disease	3	0.93	neutral	0.52	deleterious	-3	neutral	0.36	neutral	0.56	medium_impact	-0.39	medium_impact	1.62	medium_impact	0.49	0.8	16.58	21.58	0.35	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15825	15825	C	T	MI.10625	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1079	360	T	M	aCa/aTa	-3.73	0	0	benign	0.38	neutral	0.09	neutral	3.13	neutral	-0.5	neutral	-0.69	neutral_impact	0.7	0.89	neutral	0.78	neutral	0.97	10.49	neutral	0.1	0.4	NA	NA	0.36	neutral	0.29	neutral	0.16	neutral	7	0.9	neutral	0.36	neutral	-6	neutral	0.43	neutral	-0.53	medium_impact	-0.32	medium_impact	-0.56	medium_impact	0.69	0.85	16.58	21.58	0.45	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15827	15827	A	C	MI.10626	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1081	361	T	P	Aca/Cca	-10.37	0	0	possibly_damaging	0.66	neutral	0.16	neutral	3.13	neutral	-1.19	neutral	-1.32	medium_impact	2.21	0.84	neutral	0.44	neutral	1.94	15.82	deleterious	0.06	0.35	NA	NA	0.83	disease	0.53	disease	0.78	disease	6	0.86	neutral	0.25	neutral	0	NA	0.73	deleterious	-1	medium_impact	-0.17	medium_impact	0.81	medium_impact	0.33	0.8	18.68	29.24	0.3	N	0.85	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15827	15827	A	G	MI.10627	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1081	361	T	A	Aca/Gca	-10.37	0	0	benign	0.15	neutral	0.35	neutral	3.18	neutral	0.22	neutral	-0.4	medium_impact	2.21	0.78	neutral	0.75	neutral	1.96	15.94	deleterious	0.18	0.45	NA	NA	0.36	neutral	0.38	neutral	0.16	neutral	7	0.59	neutral	0.6	deleterious	-3	neutral	0.27	neutral	-0.03	medium_impact	0.08	medium_impact	0.81	medium_impact	0.46	0.8	18.68	29.24	0.39	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15827	15827	A	T	MI.10628	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1081	361	T	S	Aca/Tca	-10.37	0	0	benign	0.25	neutral	0.48	neutral	3.16	neutral	-0.25	neutral	-0.7	low_impact	1.27	0.84	neutral	0.63	neutral	1.83	15.16	deleterious	0.28	0.45	NA	NA	0.44	neutral	0.37	neutral	0.21	neutral	6	0.42	neutral	0.62	deleterious	-6	neutral	0.36	neutral	-0.29	medium_impact	0.2	medium_impact	-0.04	medium_impact	0.53	0.8	18.68	29.24	0.32	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15828	15828	C	A	MI.10629	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1082	361	T	K	aCa/aAa	-0.75	0	0	benign	0.35	neutral	0.16	neutral	3.14	neutral	-0.78	neutral	-1.08	medium_impact	2.21	0.84	neutral	0.55	neutral	2.97	22.10	deleterious	0.08	0.35	NA	NA	0.72	disease	0.51	disease	0.56	disease	1	0.81	neutral	0.41	neutral	-3	neutral	0.53	deleterious	-0.48	medium_impact	-0.17	medium_impact	0.81	medium_impact	0.57	0.8	18.68	29.24	0.33	N	0.82	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9025	9025	G	T	MI.1063	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	499	167	G	C	Ggc/Tgc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.18	deleterious	-9.86	deleterious	-8.11	high_impact	4.63	0.46	damaging	0.29	neutral	4.23	23.90	deleterious	0.13	0.65	0.99	disease	0.92	disease	0.74	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.52	0.9	49.12	8.62	0.44	N	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15828	15828	C	T	MI.10630	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1082	361	T	M	aCa/aTa	-0.75	0	0	benign	0.06	neutral	0.24	neutral	3.14	neutral	-0.74	neutral	0.62	low_impact	1.31	0.89	neutral	0.75	neutral	2.39	18.74	deleterious	0.11	0.4	NA	NA	0.49	neutral	0.27	neutral	0.45	neutral	1	0.74	neutral	0.59	deleterious	-6	neutral	0.17	neutral	0.38	medium_impact	-0.05	medium_impact	0	medium_impact	0.66	0.8	18.68	29.24	0.42	N	0.45	polymorphism	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15830	15830	A	T	MI.10631	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1084	362	I	F	Atc/Ttc	-8.08	0	0	probably_damaging	0.99	neutral	1	neutral	3.38	neutral	1.62	neutral	0.6	low_impact	0.98	0.97	neutral	0.3	neutral	0.54	7.72	deleterious	0.17	0.45	NA	NA	0.21	neutral	0.3	neutral	0.19	neutral	6	0.99	deleterious	0.51	deleterious	-2	neutral	0.67	deleterious	-2.59	low_impact	1.85	high_impact	-0.3	medium_impact	0.55	0.8	39.47	13.25	0.26	N	0.97	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15830	15830	A	C	MI.10632	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1084	362	I	L	Atc/Ctc	-8.08	0	0	probably_damaging	0.95	neutral	0.96	neutral	3.22	neutral	1.18	neutral	-0.31	neutral_impact	0.62	0.97	neutral	0.73	neutral	1.02	10.76	neutral	0.2	0.45	NA	NA	0.52	disease	0.32	neutral	0.45	neutral	1	0.95	neutral	0.51	deleterious	-2	neutral	0.59	deleterious	-1.92	low_impact	0.97	medium_impact	-0.63	medium_impact	0.40	0.8	39.47	13.25	0.23	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15830	15830	A	G	MI.10633	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1084	362	I	V	Atc/Gtc	-8.08	0	0	possibly_damaging	0.87	neutral	0.31	neutral	3.14	neutral	-0.01	neutral	-0.47	medium_impact	2.99	0.97	neutral	0.18	damaging	1.57	13.68	neutral	0.39	0.5	NA	NA	0.47	neutral	0.55	disease	0.49	neutral	0	0.89	neutral	0.22	neutral	0	NA	0.58	deleterious	-1.5	low_impact	0.03	medium_impact	1.52	medium_impact	0.48	0.8	39.47	13.25	0.39	N	0.51	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15831	15831	T	A	MI.10634	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1085	362	I	N	aTc/aAc	0.17	0.03	0	probably_damaging	1	neutral	0.19	neutral	3.07	neutral	-2.36	neutral	-2.36	medium_impact	3.45	0.94	neutral	0.13	damaging	3.09	22.50	deleterious	0.12	0.4	NA	NA	0.82	disease	0.6	disease	0.75	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.78	deleterious	-3.53	low_impact	-0.12	medium_impact	1.94	medium_impact	0.31	0.8	39.47	13.25	0.37	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15831	15831	T	G	MI.10635	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1085	362	I	S	aTc/aGc	0.17	0.03	0	probably_damaging	1	neutral	0.19	neutral	3.09	neutral	-1.31	neutral	-1.86	medium_impact	3.45	0.94	neutral	0.12	damaging	2.77	21.20	deleterious	0.05	0.35	NA	NA	0.82	disease	0.57	disease	0.75	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	-0.12	medium_impact	1.94	medium_impact	0.23	0.8	39.47	13.25	0.37	N	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15831	15831	T	C	MI.10636	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1085	362	I	T	aTc/aCc	0.17	0.03	0	probably_damaging	1	neutral	0.21	neutral	3.11	neutral	-1.02	neutral	-1.61	medium_impact	3.1	0.96	neutral	0.16	damaging	1.93	15.75	deleterious	0.07	0.35	NA	NA	0.58	disease	0.54	disease	0.66	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	-0.09	medium_impact	1.62	medium_impact	0.38	0.8	39.47	13.25	0.38	N	0.98	polymorphism	1	0.07	.	.	.	.	.	MNGIE fibroblasts / endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15832	15832	C	G	MI.10637	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1086	362	I	M	atC/atG	5.67	0.86	0	probably_damaging	1	neutral	0.22	neutral	3.08	neutral	-1.21	neutral	-0.58	medium_impact	3.25	0.96	neutral	0.19	damaging	1.88	15.45	deleterious	0.25	0.45	NA	NA	0.59	disease	0.48	neutral	0.51	disease	0	1	deleterious	0.11	neutral	1	deleterious	0.71	deleterious	-3.53	low_impact	-0.08	medium_impact	1.76	medium_impact	0.57	0.8	39.47	13.25	0.44	N	0.78	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15832	15832	C	A	MI.10638	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1086	362	I	M	atC/atA	5.67	0.86	0	probably_damaging	1	neutral	0.22	neutral	3.08	neutral	-1.21	neutral	-0.58	medium_impact	3.25	0.96	neutral	0.19	damaging	2.34	18.46	deleterious	0.25	0.45	NA	NA	0.59	disease	0.48	neutral	0.51	disease	0	1	deleterious	0.11	neutral	1	deleterious	0.71	deleterious	-3.53	low_impact	-0.08	medium_impact	1.76	medium_impact	0.57	0.8	39.47	13.25	0.44	N	0.78	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15833	15833	C	A	MI.10639	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1087	363	L	M	Cta/Ata	-3.27	0	0.05	probably_damaging	1	neutral	0.22	neutral	2.9	neutral	-2.46	neutral	-0.9	medium_impact	2.88	0.88	neutral	0.48	neutral	2.16	17.26	deleterious	0.2	0.45	NA	NA	0.52	disease	0.53	disease	0.5	neutral	0	1	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	-0.08	medium_impact	1.42	medium_impact	0.51	0.8	23.95	24.64	0.42	N	0.63	polymorphism	1	0.04	rs41504845	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9026	9026	G	A	MI.1064	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	500	167	G	D	gGc/gAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.24	deleterious	-5.55	deleterious	-6.28	high_impact	4.29	0.53	damaging	0.34	neutral	3.98	23.60	deleterious	0.12	0.65	0.7	disease	0.93	disease	0.81	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.58	high_impact	0.29	0.9	49.12	8.62	0.56	P	1.00	disease_causing	1	0.32	.	.	.	.	.	.	COSM1155689	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15833	15833	C	G	MI.10640	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1087	363	L	V	Cta/Gta	-3.27	0	0.05	probably_damaging	0.92	neutral	0.23	neutral	2.98	neutral	-0.79	neutral	-1.2	medium_impact	2.65	0.9	neutral	0.67	neutral	1.82	15.11	deleterious	0.23	0.45	NA	NA	0.57	disease	0.56	disease	0.46	neutral	1	0.94	neutral	0.16	neutral	1	deleterious	0.73	deleterious	-1.72	low_impact	-0.06	medium_impact	1.21	medium_impact	0.44	0.8	23.95	24.64	0.41	N	0.64	polymorphism	1	0.04	rs41504845	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15834	15834	T	C	MI.10641	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1088	363	L	P	cTa/cCa	-0.29	0	0	probably_damaging	1	deleterious	0.04	neutral	2.89	deleterious	-4.11	deleterious	-3.25	high_impact	4.42	0.83	neutral	0.29	neutral	2.37	18.66	deleterious	0.03	0.35	NA	NA	0.82	disease	0.7	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-3.53	low_impact	-0.53	medium_impact	2.82	high_impact	0.37	0.8	23.95	24.64	0.43	N	0.92	polymorphism	1	0.20	rs878937787	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15834	15834	T	A	MI.10642	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1088	363	L	Q	cTa/cAa	-0.29	0	0	probably_damaging	1	neutral	0.05	neutral	2.89	deleterious	-3.63	deleterious	-2.82	high_impact	4.42	0.84	neutral	0.38	neutral	2.55	19.79	deleterious	0.04	0.35	NA	NA	0.76	disease	0.65	disease	0.65	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.47	medium_impact	2.82	high_impact	0.33	0.8	23.95	24.64	0.46	N	0.93	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15834	15834	T	G	MI.10643	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1088	363	L	R	cTa/cGa	-0.29	0	0	probably_damaging	1	neutral	0.07	neutral	2.9	deleterious	-3.49	deleterious	-2.84	high_impact	4.42	0.84	neutral	0.33	neutral	2.62	20.30	deleterious	0.03	0.35	NA	NA	0.88	disease	0.75	disease	0.8	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.39	medium_impact	2.82	high_impact	0.16	0.8	23.95	24.64	0.49	N	0.99	polymorphism	1	0.35	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15836	15836	A	G	MI.10644	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1090	364	I	V	Atc/Gtc	-5.56	0	0	benign	0	neutral	0.52	neutral	3.13	neutral	-0.13	neutral	-0.18	neutral_impact	0.54	1	neutral	0.97	neutral	-0.28	0.75	neutral	0.46	0.55	NA	NA	0.12	neutral	0.33	neutral	0.23	neutral	5	0.48	neutral	0.76	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.24	medium_impact	-0.7	medium_impact	0.43	0.8	18.42	19.71	0.35	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15836	15836	A	C	MI.10645	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1090	364	I	L	Atc/Ctc	-5.56	0	0	benign	0	neutral	1	neutral	3.15	neutral	-0.79	neutral	-0.56	neutral_impact	0.61	0.97	neutral	0.85	neutral	0.98	10.55	neutral	0.24	0.45	NA	NA	0.49	neutral	0.31	neutral	0.34	neutral	3	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	1.85	high_impact	-0.64	medium_impact	0.39	0.8	18.42	19.71	0.24	N	0.11	polymorphism	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15836	15836	A	T	MI.10646	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1090	364	I	F	Atc/Ttc	-5.56	0	0	benign	0.11	neutral	0.83	neutral	3.05	neutral	-2.71	neutral	-1.49	low_impact	1.45	0.96	neutral	0.84	neutral	2.17	17.31	deleterious	0.18	0.45	NA	NA	0.67	disease	0.37	neutral	0.49	neutral	0	0.07	neutral	0.86	deleterious	-6	neutral	0.16	neutral	0.12	medium_impact	0.6	medium_impact	0.12	medium_impact	0.40	0.8	18.42	19.71	0.2	N	0.77	polymorphism	1	0.04	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15837	15837	T	A	MI.10647	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1091	364	I	N	aTc/aAc	-4.64	0	0	possibly_damaging	0.62	neutral	0.17	neutral	2.98	deleterious	-4.38	deleterious	-2.87	high_impact	3.87	0.93	neutral	0.49	neutral	3.09	22.50	deleterious	0.12	0.4	NA	NA	0.78	disease	0.64	disease	0.72	disease	4	0.84	neutral	0.28	neutral	1	deleterious	0.38	neutral	-0.93	medium_impact	-0.15	medium_impact	2.32	high_impact	0.27	0.8	18.42	19.71	0.44	N	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15837	15837	T	C	MI.10648	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1091	364	I	T	aTc/aCc	-4.64	0	0	benign	0.09	neutral	0.28	neutral	3.04	neutral	-2.51	neutral	-1.8	medium_impact	3.06	0.98	neutral	0.69	neutral	0.82	9.61	deleterious	0.13	0.4	NA	NA	0.54	disease	0.45	neutral	0.47	neutral	1	0.68	neutral	0.6	deleterious	-3	neutral	0.17	neutral	0.21	medium_impact	0	medium_impact	1.59	medium_impact	0.27	0.8	18.42	19.71	0.38	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15837	15837	T	G	MI.10649	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1091	364	I	S	aTc/aGc	-4.64	0	0	benign	0.24	neutral	0.45	neutral	3.02	deleterious	-3.24	neutral	-2.36	medium_impact	2.83	0.93	neutral	0.67	neutral	2.76	21.10	deleterious	0.05	0.35	NA	NA	0.8	disease	0.46	neutral	0.64	disease	3	0.46	neutral	0.61	deleterious	-3	neutral	0.25	neutral	-0.26	medium_impact	0.18	medium_impact	1.38	medium_impact	0.24	0.8	18.42	19.71	0.3	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9026	9026	G	T	MI.1065	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	500	167	G	V	gGc/gTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.18	deleterious	-8.86	deleterious	-8.07	high_impact	4.63	0.43	damaging	0.36	neutral	3.84	23.40	deleterious	0.12	0.65	0.96	disease	0.92	disease	0.76	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.45	0.9	49.12	8.62	0.64	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15838	15838	C	G	MI.10650	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1092	364	I	M	atC/atG	4.52	0.62	0	benign	0.01	neutral	0.16	neutral	3.01	deleterious	-3.05	neutral	-0.86	medium_impact	2.51	0.95	neutral	0.54	neutral	1.88	15.48	deleterious	0.35	0.5	NA	NA	0.52	disease	0.36	neutral	0.48	neutral	1	0.84	neutral	0.58	deleterious	-3	neutral	0.12	neutral	1.13	medium_impact	-0.17	medium_impact	1.09	medium_impact	0.49	0.8	18.42	19.71	0.4	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15838	15838	C	A	MI.10651	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1092	364	I	M	atC/atA	4.52	0.62	0	benign	0.01	neutral	0.16	neutral	3.01	deleterious	-3.05	neutral	-0.86	medium_impact	2.51	0.95	neutral	0.54	neutral	2.35	18.49	deleterious	0.35	0.5	NA	NA	0.52	disease	0.36	neutral	0.48	neutral	1	0.84	neutral	0.58	deleterious	-3	neutral	0.12	neutral	1.13	medium_impact	-0.17	medium_impact	1.09	medium_impact	0.49	0.8	18.42	19.71	0.4	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15839	15839	C	A	MI.10652	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1093	365	L	M	Cta/Ata	-8.31	0	0	probably_damaging	0.99	neutral	0.28	neutral	2.97	neutral	-2.33	neutral	-0.72	low_impact	1.92	0.9	neutral	0.78	neutral	1.07	11.07	neutral	0.27	0.45	NA	NA	0.37	neutral	0.28	neutral	0.19	neutral	6	0.99	deleterious	0.15	neutral	-2	neutral	0.71	deleterious	-2.59	low_impact	0	medium_impact	0.55	medium_impact	0.64	0.8	52.37	9.23	0.45	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15839	15839	C	G	MI.10653	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1093	365	L	V	Cta/Gta	-8.31	0	0	possibly_damaging	0.84	neutral	0.54	neutral	3.02	neutral	-0.45	neutral	-1.03	medium_impact	2.63	0.92	neutral	0.28	neutral	1.81	15.03	deleterious	0.24	0.45	NA	NA	0.53	disease	0.44	neutral	0.47	neutral	1	0.82	neutral	0.35	neutral	0	NA	0.66	deleterious	-1.4	low_impact	0.26	medium_impact	1.19	medium_impact	0.62	0.8	52.37	9.23	0.26	N	0.68	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15840	15840	T	A	MI.10654	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1094	365	L	Q	cTa/cAa	-3.27	0	0	probably_damaging	0.99	neutral	0.26	neutral	2.94	deleterious	-3.13	deleterious	-2.55	high_impact	4.08	0.86	neutral	0.14	damaging	2.54	19.70	deleterious	0.07	0.35	NA	NA	0.73	disease	0.49	neutral	0.49	neutral	0	0.99	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	-0.02	medium_impact	2.51	high_impact	0.26	0.8	52.37	9.23	0.35	N	0.93	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15840	15840	T	C	MI.10655	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1094	365	L	P	cTa/cCa	-3.27	0	0	probably_damaging	1	neutral	0.31	neutral	2.93	deleterious	-3.78	deleterious	-3.01	high_impact	4.08	0.87	neutral	0.09	damaging	2.36	18.56	deleterious	0.05	0.35	NA	NA	0.83	disease	0.63	disease	0.71	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.03	medium_impact	2.51	high_impact	0.35	0.8	52.37	9.23	0.31	N	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15840	15840	T	G	MI.10656	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1094	365	L	R	cTa/cGa	-3.27	0	0	probably_damaging	0.99	neutral	0.33	neutral	2.95	deleterious	-3.05	deleterious	-2.59	high_impact	4.08	0.87	neutral	0.09	damaging	2.60	20.20	deleterious	0.04	0.35	NA	NA	0.88	disease	0.63	disease	0.73	disease	5	0.99	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-2.59	low_impact	0.06	medium_impact	2.51	high_impact	0.25	0.8	52.37	9.23	0.3	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15842	15842	A	G	MI.10657	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1096	366	M	V	Ata/Gta	-11.75	0	0	benign	0	neutral	0.52	neutral	3.18	neutral	0.23	neutral	-0.59	medium_impact	2.7	0.98	neutral	0.63	neutral	1.01	10.70	neutral	0.19	0.45	NA	NA	0.71	disease	0.48	neutral	0.52	disease	0	0.48	neutral	0.76	deleterious	-3	neutral	0.21	neutral	2.07	high_impact	0.24	medium_impact	1.26	medium_impact	0.33	0.8	21.58	16.1	0.25	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15842	15842	A	T	MI.10658	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1096	366	M	L	Ata/Tta	-11.75	0	0	benign	0	neutral	0.93	neutral	3.27	neutral	1.35	neutral	-0.39	low_impact	1.38	0.97	neutral	0.77	neutral	0.40	6.62	deleterious	0.22	0.45	NA	NA	0.63	disease	0.31	neutral	0.45	neutral	1	0.05	neutral	0.97	deleterious	-6	neutral	0.19	neutral	2.07	high_impact	0.83	medium_impact	0.06	medium_impact	0.27	0.8	21.58	16.1	0.24	N	0.77	polymorphism	1	0.01	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15842	15842	A	C	MI.10659	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1096	366	M	L	Ata/Cta	-11.75	0	0	benign	0	neutral	0.93	neutral	3.27	neutral	1.35	neutral	-0.39	low_impact	1.38	0.97	neutral	0.77	neutral	0.30	5.67	deleterious	0.22	0.45	NA	NA	0.63	disease	0.31	neutral	0.45	neutral	1	0.05	neutral	0.97	deleterious	-6	neutral	0.19	neutral	2.07	high_impact	0.83	medium_impact	0.06	medium_impact	0.27	0.8	21.58	16.1	0.23	N	0.77	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9026	9026	G	C	MI.1066	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	500	167	G	A	gGc/gCc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.22	deleterious	-6	deleterious	-5.34	high_impact	4.63	0.56	damaging	0.45	neutral	3.19	22.70	deleterious	0.24	0.65	0.91	disease	0.79	disease	0.7	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.60	0.9	49.12	8.62	0.54	P	0.79	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15843	15843	T	A	MI.10660	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1097	366	M	K	aTa/aAa	-0.29	0	0	benign	0.08	neutral	0.4	neutral	3.11	neutral	-2.15	neutral	-1.67	high_impact	3.64	0.93	neutral	0.34	neutral	2.29	18.09	deleterious	0.04	0.35	NA	NA	0.87	disease	0.6	disease	0.75	disease	5	0.55	neutral	0.66	deleterious	-2	neutral	0.40	neutral	0.26	medium_impact	0.13	medium_impact	2.11	high_impact	0.23	0.8	21.58	16.1	0.3	N	0.97	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15843	15843	T	C	MI.10661	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1097	366	M	T	aTa/aCa	-0.29	0	0	benign	0.07	neutral	0.39	neutral	3.14	neutral	-0.83	neutral	-1.11	medium_impact	2.57	0.92	neutral	0.48	neutral	1.17	11.59	neutral	0.15	0.4	NA	NA	0.68	disease	0.41	neutral	0.48	neutral	0	0.57	neutral	0.66	deleterious	-3	neutral	0.30	neutral	0.32	medium_impact	0.12	medium_impact	1.14	medium_impact	0.15	0.8	21.58	16.1	0.31	N	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15844	15844	A	T	MI.10662	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1098	366	M	I	atA/atT	2.69	0.06	0	benign	0.01	neutral	0.55	neutral	3.18	neutral	-0.27	neutral	-0.5	low_impact	1.31	0.95	neutral	0.7	neutral	0.52	7.56	deleterious	0.28	0.45	NA	NA	0.53	disease	0.35	neutral	0.45	neutral	1	0.44	neutral	0.77	deleterious	-6	neutral	0.18	neutral	1.13	medium_impact	0.27	medium_impact	0	medium_impact	0.36	0.8	21.58	16.1	0.28	N	0.85	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15844	15844	A	C	MI.10663	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1098	366	M	I	atA/atC	2.69	0.06	0	benign	0.01	neutral	0.55	neutral	3.18	neutral	-0.27	neutral	-0.5	low_impact	1.31	0.95	neutral	0.7	neutral	0.44	6.99	deleterious	0.28	0.45	NA	NA	0.53	disease	0.35	neutral	0.45	neutral	1	0.44	neutral	0.77	deleterious	-6	neutral	0.18	neutral	1.13	medium_impact	0.27	medium_impact	0	medium_impact	0.36	0.8	21.58	16.1	0.28	N	0.85	disease_causing	1	0.02	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15845	15845	C	G	MI.10664	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1099	367	P	A	Cca/Gca	-1.67	0	0	probably_damaging	0.97	neutral	0.66	neutral	3	deleterious	-4.23	deleterious	-3.92	high_impact	4.67	0.94	neutral	0.15	damaging	1.39	12.72	neutral	0.13	0.4	NA	NA	0.63	disease	0.67	disease	0.67	disease	3	0.97	neutral	0.35	neutral	2	deleterious	0.78	deleterious	-2.14	low_impact	0.38	medium_impact	3.05	high_impact	0.56	0.8	57.63	8.36	0.44	N	0.82	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15845	15845	C	T	MI.10665	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1099	367	P	S	Cca/Tca	-1.67	0	0	probably_damaging	0.99	neutral	0.55	neutral	2.98	deleterious	-4.46	deleterious	-3.92	high_impact	4.33	0.93	neutral	0.11	damaging	3.60	23.20	deleterious	0.13	0.4	NA	NA	0.81	disease	0.58	disease	0.67	disease	3	0.99	deleterious	0.28	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.27	medium_impact	2.74	high_impact	0.15	0.8	57.63	8.36	0.29	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15845	15845	C	A	MI.10666	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1099	367	P	T	Cca/Aca	-1.67	0	0	probably_damaging	0.99	neutral	0.5	neutral	2.99	deleterious	-4.87	deleterious	-3.91	high_impact	4.12	0.92	neutral	0.12	damaging	3.38	23.00	deleterious	0.15	0.4	NA	NA	0.8	disease	0.65	disease	0.69	disease	4	0.99	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.22	medium_impact	2.55	high_impact	0.45	0.8	57.63	8.36	0.32	N	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15846	15846	C	A	MI.10667	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1100	367	P	Q	cCa/cAa	5.44	0.99	0	probably_damaging	1	neutral	0.41	neutral	2.96	deleterious	-5.44	deleterious	-3.92	high_impact	4.67	0.93	neutral	0.09	damaging	4.09	23.70	deleterious	0.13	0.4	NA	NA	0.85	disease	0.7	disease	0.76	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.14	medium_impact	3.05	high_impact	0.33	0.8	57.63	8.36	0.57	P	0.85	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15846	15846	C	G	MI.10668	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1100	367	P	R	cCa/cGa	5.44	0.99	0	probably_damaging	1	neutral	0.45	neutral	2.97	deleterious	-5.26	deleterious	-4.41	high_impact	4.33	0.96	neutral	0.09	damaging	3.53	23.10	deleterious	0.07	0.35	NA	NA	0.9	disease	0.76	disease	0.79	disease	6	1	deleterious	0.23	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.18	medium_impact	2.74	high_impact	0.34	0.8	57.63	8.36	0.55	P	0.81	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15846	15846	C	T	MI.10669	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1100	367	P	L	cCa/cTa	5.44	0.99	0	probably_damaging	1	neutral	0.71	neutral	3.12	deleterious	-5.07	deleterious	-4.85	medium_impact	2.86	0.96	neutral	0.08	damaging	4.28	24.00	deleterious	0.08	0.35	NA	NA	0.88	disease	0.48	neutral	0.73	disease	5	1	deleterious	0.36	neutral	1	deleterious	0.85	deleterious	-3.53	low_impact	0.43	medium_impact	1.4	medium_impact	0.56	0.8	57.63	8.36	0.38	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9028	9028	C	G	MI.1067	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	502	168	H	D	Cac/Gac	-20	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.09	deleterious	-3.67	deleterious	-7.88	high_impact	3.92	0.61	neutral	0.34	neutral	3.90	23.50	deleterious	0.2	0.65	0.83	disease	0.9	disease	0.8	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-0.84	medium_impact	2.26	high_impact	0.32	0.9	48.23	8.83	0.4	N	1.00	disease_causing	0.89	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15848	15848	A	C	MI.10670	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1102	368	T	P	Act/Cct	-12.9	0	0.01	benign	0.07	neutral	0.32	neutral	3.12	neutral	-2	neutral	-1.38	medium_impact	2.12	0.97	neutral	0.43	neutral	1.83	15.17	deleterious	0.07	0.35	NA	NA	0.78	disease	0.63	disease	0.78	disease	6	0.64	neutral	0.63	deleterious	-3	neutral	0.22	neutral	0.32	medium_impact	0.05	medium_impact	0.73	medium_impact	0.38	0.8	8.68	30.15	0.25	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15848	15848	A	G	MI.10671	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1102	368	T	A	Act/Gct	-12.9	0	0.01	benign	0	neutral	0.51	neutral	3.17	neutral	0.62	neutral	-0.46	neutral_impact	0.44	0.98	neutral	0.95	neutral	0.50	7.47	deleterious	0.38	0.5	NA	NA	0.21	neutral	0.42	neutral	0.17	neutral	7	0.49	neutral	0.76	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.23	medium_impact	-0.79	medium_impact	0.44	0.8	8.68	30.15	0.33	N	0.04	polymorphism	1	0.01	rs1057520206	Uncertain_significance	not_provided	364247	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15848	15848	A	T	MI.10672	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1102	368	T	S	Act/Tct	-12.9	0	0.01	benign	0	neutral	0.4	neutral	3.16	neutral	-0.42	neutral	-0.75	low_impact	1.43	0.96	neutral	0.84	neutral	1.53	13.45	neutral	0.42	0.55	NA	NA	0.32	neutral	0.39	neutral	0.15	neutral	7	0.59	neutral	0.7	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.13	medium_impact	0.11	medium_impact	0.51	0.8	8.68	30.15	0.34	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15849	15849	C	G	MI.10673	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1103	368	T	S	aCt/aGt	-9.23	0	0	benign	0	neutral	0.4	neutral	3.16	neutral	-0.42	neutral	-0.75	low_impact	1.43	0.96	neutral	0.84	neutral	1.60	13.86	neutral	0.42	0.55	NA	NA	0.32	neutral	0.39	neutral	0.15	neutral	7	0.59	neutral	0.7	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.13	medium_impact	0.11	medium_impact	0.51	0.8	8.68	30.15	0.31	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15849	15849	C	A	MI.10674	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1103	368	T	N	aCt/aAt	-9.23	0	0	benign	0.07	neutral	0.35	neutral	3.12	neutral	-1.63	neutral	-1.31	medium_impact	2.33	0.92	neutral	0.61	neutral	2.01	16.25	deleterious	0.36	0.5	NA	NA	0.51	disease	0.53	disease	0.58	disease	2	0.61	neutral	0.64	deleterious	-3	neutral	0.15	neutral	0.32	medium_impact	0.08	medium_impact	0.92	medium_impact	0.59	0.8	8.68	30.15	0.32	N	0.42	polymorphism	1	0.03	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15849	15849	C	T	MI.10675	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1103	368	T	I	aCt/aTt	-9.23	0	0	benign	0	neutral	0.47	neutral	3.28	neutral	1.24	neutral	0.39	neutral_impact	-0.79	0.98	neutral	0.98	neutral	0.33	5.98	deleterious	0.2	0.45	NA	NA	0.32	neutral	0.27	neutral	0.17	neutral	7	0.53	neutral	0.74	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.19	medium_impact	-1.91	low_impact	0.65	0.8	8.68	30.15	0.27	N	0.01	polymorphism	1	0.00	rs202225494	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15851	15851	A	C	MI.10676	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1105	369	I	L	Atc/Ctc	-13.35	0	0.06	benign	0.02	neutral	0.74	neutral	3.22	neutral	-0.1	neutral	-0.13	low_impact	1.04	0.93	neutral	0.53	neutral	0.90	10.05	neutral	0.21	0.45	NA	NA	0.33	neutral	0.2	neutral	0.17	neutral	7	0.22	neutral	0.86	deleterious	-6	neutral	0.11	neutral	0.85	medium_impact	0.47	medium_impact	-0.25	medium_impact	0.42	0.8	13.42	21.02	0.35	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15851	15851	A	T	MI.10677	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1105	369	I	F	Atc/Ttc	-13.35	0	0.06	benign	0.14	neutral	0.74	neutral	3.11	neutral	-2.09	neutral	-0.82	medium_impact	2.29	0.98	neutral	0.82	neutral	2.24	17.78	deleterious	0.17	0.45	NA	NA	0.47	neutral	0.28	neutral	0.33	neutral	3	0.14	neutral	0.8	deleterious	-3	neutral	0.20	neutral	0	medium_impact	0.47	medium_impact	0.89	medium_impact	0.48	0.8	13.42	21.02	0.29	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15851	15851	A	G	MI.10678	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1105	369	I	V	Atc/Gtc	-13.35	0	0.06	benign	0.01	neutral	0.53	neutral	3.17	neutral	-0.31	neutral	0.19	low_impact	1.35	0.98	neutral	0.94	neutral	0.01	2.65	deleterious	0.25	0.45	NA	NA	0.17	neutral	0.25	neutral	0.22	neutral	6	0.46	neutral	0.76	deleterious	-6	neutral	0.09	neutral	1.13	medium_impact	0.25	medium_impact	0.03	medium_impact	0.23	0.8	13.42	21.02	0.34	N	0.04	polymorphism	1	0.01	rs3094281	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15852	15852	T	G	MI.10679	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1106	369	I	S	aTc/aGc	-4.87	0	0	benign	0	neutral	0.45	neutral	3.12	neutral	-1.99	neutral	-0.13	low_impact	0.88	0.96	neutral	0.97	neutral	1.31	12.35	neutral	0.06	0.35	NA	NA	0.47	neutral	0.29	neutral	0.27	neutral	5	0.54	neutral	0.73	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	0.18	medium_impact	-0.39	medium_impact	0.14	0.8	13.42	21.02	0.36	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9028	9028	C	T	MI.1068	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	502	168	H	Y	Cac/Tac	-20	0	0	probably_damaging	0.98	deleterious	0	neutral	4.03	deleterious	-6.48	deleterious	-5.3	high_impact	4.62	0.56	damaging	0.27	damaging	3.82	23.40	deleterious	0.35	0.65	0.95	disease	0.9	disease	0.75	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.36	low_impact	-1.4	low_impact	2.86	high_impact	0.33	0.9	48.23	8.83	0.41	N	1.00	disease_causing	0.76	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15852	15852	T	C	MI.10680	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1106	369	I	T	aTc/aCc	-4.87	0	0	benign	0.05	neutral	0.43	neutral	3.15	neutral	-1.48	neutral	0.04	neutral_impact	-0.02	0.98	neutral	0.97	neutral	0.07	3.28	deleterious	0.13	0.4	NA	NA	0.14	neutral	0.26	neutral	0.19	neutral	6	0.53	neutral	0.69	deleterious	-6	neutral	0.09	neutral	0.46	medium_impact	0.16	medium_impact	-1.21	low_impact	0.23	0.8	13.42	21.02	0.39	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15852	15852	T	A	MI.10681	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1106	369	I	N	aTc/aAc	-4.87	0	0	benign	0.08	neutral	0.38	neutral	3.08	deleterious	-3.22	neutral	-1.09	medium_impact	2.22	0.92	neutral	0.53	neutral	4.21	23.90	deleterious	0.11	0.4	NA	NA	0.61	disease	0.33	neutral	0.5	neutral	0	0.57	neutral	0.65	deleterious	-3	neutral	0.19	neutral	0.26	medium_impact	0.11	medium_impact	0.82	medium_impact	0.14	0.8	13.42	21.02	0.3	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15853	15853	C	G	MI.10682	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1107	369	I	M	atC/atG	0.17	0	0	benign	0.31	neutral	0.23	neutral	3.09	neutral	-2.05	neutral	-0.21	low_impact	1.15	0.94	neutral	0.52	neutral	1.74	14.65	neutral	0.26	0.45	NA	NA	0.31	neutral	0.25	neutral	0.18	neutral	6	0.72	neutral	0.46	neutral	-6	neutral	0.18	neutral	-0.41	medium_impact	-0.06	medium_impact	-0.15	medium_impact	0.55	0.8	13.42	21.02	0.43	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15853	15853	C	A	MI.10683	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1107	369	I	M	atC/atA	0.17	0	0	benign	0.31	neutral	0.23	neutral	3.09	neutral	-2.05	neutral	-0.21	low_impact	1.15	0.94	neutral	0.52	neutral	2.14	17.11	deleterious	0.26	0.45	NA	NA	0.31	neutral	0.25	neutral	0.18	neutral	6	0.72	neutral	0.46	neutral	-6	neutral	0.18	neutral	-0.41	medium_impact	-0.06	medium_impact	-0.15	medium_impact	0.55	0.8	13.42	21.02	0.42	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15854	15854	T	A	MI.10684	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1108	370	S	T	Tcc/Acc	-4.64	0	0	probably_damaging	0.97	neutral	0.54	neutral	3.12	neutral	-0.04	neutral	-0.93	medium_impact	2.12	0.93	neutral	0.65	neutral	2.04	16.46	deleterious	0.21	0.45	NA	NA	0.44	neutral	0.35	neutral	0.21	neutral	6	0.97	neutral	0.29	neutral	1	deleterious	0.69	deleterious	-2.14	low_impact	0.26	medium_impact	0.73	medium_impact	0.52	0.8	18.68	18.73	0.28	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15854	15854	T	G	MI.10685	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1108	370	S	A	Tcc/Gcc	-4.64	0	0	probably_damaging	0.96	neutral	0.69	neutral	3.12	neutral	-0.89	neutral	-0.13	low_impact	1.88	0.97	neutral	0.83	neutral	0.61	8.25	deleterious	0.24	0.45	NA	NA	0.28	neutral	0.2	neutral	0.18	neutral	6	0.95	neutral	0.37	neutral	-2	neutral	0.67	deleterious	-2.02	low_impact	0.41	medium_impact	0.51	medium_impact	0.36	0.8	18.68	18.73	0.3	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15854	15854	T	C	MI.10686	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1108	370	S	P	Tcc/Ccc	-4.64	0	0	probably_damaging	0.99	neutral	0.28	neutral	3.06	neutral	-2.82	neutral	-1.36	medium_impact	3.22	0.94	neutral	0.34	neutral	2.38	18.66	deleterious	0.06	0.35	NA	NA	0.89	disease	0.64	disease	0.79	disease	6	0.99	deleterious	0.15	neutral	1	deleterious	0.82	deleterious	-2.59	low_impact	0	medium_impact	1.73	medium_impact	0.18	0.8	18.68	18.73	0.34	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15855	15855	C	G	MI.10687	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1109	370	S	C	tCc/tGc	-0.52	0	0	probably_damaging	1	neutral	0.19	neutral	3.04	deleterious	-4.14	neutral	-1.51	high_impact	3.91	0.95	neutral	0.37	neutral	3.48	23.10	deleterious	0.09	0.35	NA	NA	0.69	disease	0.4	neutral	0.5	neutral	0	1	deleterious	0.1	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	-0.12	medium_impact	2.36	high_impact	0.22	0.8	18.68	18.73	0.43	N	0.62	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15855	15855	C	A	MI.10688	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1109	370	S	Y	tCc/tAc	-0.52	0	0	probably_damaging	1	neutral	1	neutral	3.08	deleterious	-3.18	neutral	-1.8	medium_impact	3.22	0.94	neutral	0.51	neutral	3.90	23.50	deleterious	0.07	0.35	NA	NA	0.76	disease	0.3	neutral	0.58	disease	2	0.99	deleterious	0.5	deleterious	1	deleterious	0.77	deleterious	-3.53	low_impact	1.85	high_impact	1.73	medium_impact	0.28	0.8	18.68	18.73	0.19	N	0.90	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15855	15855	C	T	MI.10689	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1109	370	S	F	tCc/tTc	-0.52	0	0	probably_damaging	1	neutral	0.71	neutral	3.09	deleterious	-3.3	neutral	-1.82	medium_impact	3.02	0.95	neutral	0.49	neutral	3.99	23.60	deleterious	0.06	0.35	NA	NA	0.77	disease	0.46	neutral	0.61	disease	2	0.99	deleterious	0.36	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.43	medium_impact	1.55	medium_impact	0.09	0.8	18.68	18.73	0.23	N	0.91	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9028	9028	C	A	MI.1069	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	502	168	H	N	Cac/Aac	-20	0	0	probably_damaging	0.98	deleterious	0	neutral	4.08	deleterious	-4.38	deleterious	-6.05	high_impact	4.62	0.57	damaging	0.33	neutral	3.91	23.50	deleterious	0.41	0.65	0.86	disease	0.87	disease	0.74	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.36	low_impact	-1.4	low_impact	2.86	high_impact	0.42	0.9	48.23	8.83	0.44	N	0.98	disease_causing	0.72	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15857	15857	C	A	MI.10690	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1111	371	L	M	Cta/Ata	-5.33	0	0	probably_damaging	1	neutral	0.28	neutral	3.04	neutral	-1.45	neutral	-0.1	low_impact	1.15	0.93	neutral	0.87	neutral	2.19	17.44	deleterious	0.3	0.45	NA	NA	0.22	neutral	0.12	neutral	0.17	neutral	7	1	deleterious	0.14	neutral	-2	neutral	0.67	deleterious	-3.53	low_impact	0	medium_impact	-0.15	medium_impact	0.68	0.85	12.63	28.66	0.53	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15857	15857	C	G	MI.10691	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1111	371	L	V	Cta/Gta	-5.33	0	0	probably_damaging	0.98	neutral	0.65	neutral	3.06	neutral	-1.02	neutral	-0.43	low_impact	1.87	0.97	neutral	0.72	neutral	0.77	9.28	deleterious	0.25	0.45	NA	NA	0.38	neutral	0.29	neutral	0.17	neutral	7	0.98	deleterious	0.34	neutral	-2	neutral	0.69	deleterious	-2.31	low_impact	0.37	medium_impact	0.51	medium_impact	0.48	0.8	12.63	28.66	0.29	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15858	15858	T	A	MI.10692	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1112	371	L	Q	cTa/cAa	-7.62	0	0	probably_damaging	1	neutral	0.57	neutral	3	neutral	-2.31	neutral	-1	medium_impact	2.84	0.93	neutral	0.63	neutral	3.98	23.60	deleterious	0.06	0.35	NA	NA	0.61	disease	0.36	neutral	0.48	neutral	0	1	deleterious	0.29	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	0.29	medium_impact	1.39	medium_impact	0.18	0.8	12.63	28.66	0.26	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15858	15858	T	C	MI.10693	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1112	371	L	P	cTa/cCa	-7.62	0	0	probably_damaging	1	neutral	0.34	neutral	2.99	neutral	-2.69	neutral	-1.56	medium_impact	2.98	0.93	neutral	0.36	neutral	3.84	23.40	deleterious	0.04	0.35	NA	NA	0.85	disease	0.52	disease	0.75	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.07	medium_impact	1.51	medium_impact	0.15	0.8	12.63	28.66	0.32	N	0.82	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15858	15858	T	G	MI.10694	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1112	371	L	R	cTa/cGa	-7.62	0	0	probably_damaging	1	neutral	0.59	neutral	3.03	neutral	-1.62	neutral	-1.16	medium_impact	1.99	0.94	neutral	0.48	neutral	4.07	23.70	deleterious	0.05	0.35	NA	NA	0.84	disease	0.44	neutral	0.75	disease	5	1	deleterious	0.3	neutral	1	deleterious	0.82	deleterious	-3.53	low_impact	0.31	medium_impact	0.61	medium_impact	0.17	0.8	12.63	28.66	0.21	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15860	15860	A	G	MI.10695	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1114	372	I	V	Att/Gtt	-4.19	0	0.06	benign	0	neutral	0.48	neutral	3.14	neutral	-0.21	neutral	-0.21	low_impact	1.38	0.98	neutral	0.96	neutral	-0.04	2.24	deleterious	0.49	0.55	NA	NA	0.17	neutral	0.38	neutral	0.21	neutral	6	0.52	neutral	0.74	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	0.2	medium_impact	0.06	medium_impact	0.36	0.8	19.47	32.29	0.34	N	0.09	polymorphism	1	0.01	rs201023973	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15860	15860	A	C	MI.10696	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1114	372	I	L	Att/Ctt	-4.19	0	0.06	benign	0.01	neutral	1	neutral	3.23	neutral	-0.08	neutral	0.15	low_impact	1.03	0.94	neutral	0.87	neutral	-0.13	1.54	neutral	0.23	0.45	NA	NA	0.14	neutral	0.13	neutral	0.2	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.07	neutral	1.13	medium_impact	1.85	high_impact	-0.26	medium_impact	0.65	0.8	19.47	32.29	0.34	N	0.25	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15860	15860	A	T	MI.10697	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1114	372	I	F	Att/Ttt	-4.19	0	0.06	benign	0.19	neutral	0.59	neutral	3.1	neutral	-1.65	neutral	-0.98	medium_impact	2.44	0.98	neutral	0.93	neutral	1.93	15.77	deleterious	0.12	0.4	NA	NA	0.47	neutral	0.24	neutral	0.27	neutral	5	0.3	neutral	0.7	deleterious	-3	neutral	0.39	neutral	-0.14	medium_impact	0.31	medium_impact	1.02	medium_impact	0.54	0.8	19.47	32.29	0.34	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15861	15861	T	A	MI.10698	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1115	372	I	N	aTt/aAt	-2.12	0	0	possibly_damaging	0.71	neutral	0.33	neutral	3.07	deleterious	-3.05	neutral	-2.25	medium_impact	3.28	0.86	neutral	0.51	neutral	2.81	21.40	deleterious	0.07	0.35	NA	NA	0.65	disease	0.47	neutral	0.48	neutral	0	0.76	neutral	0.31	neutral	0	NA	0.63	deleterious	-1.09	low_impact	0.06	medium_impact	1.79	medium_impact	0.19	0.8	19.47	32.29	0.34	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15861	15861	T	G	MI.10699	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1115	372	I	S	aTt/aGt	-2.12	0	0	benign	0.35	neutral	0.41	neutral	3.09	neutral	-2	neutral	-1.68	medium_impact	3.28	0.96	neutral	0.46	neutral	2.59	20.10	deleterious	0.02	0.35	NA	NA	0.61	disease	0.46	neutral	0.48	neutral	0	0.51	neutral	0.53	deleterious	-3	neutral	0.42	neutral	-0.48	medium_impact	0.14	medium_impact	1.79	medium_impact	0.16	0.8	19.47	32.29	0.3	N	0.81	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8575	8575	C	A	MI.107	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	49	17	L	M	Cta/Ata	-11.44	0	0	probably_damaging	1	neutral	0.36	neutral	4.48	neutral	-2.48	neutral	-0.98	low_impact	1.01	0.96	neutral	0.79	neutral	2.39	18.77	deleterious	0.38	0.65	0.67	disease	0.4	neutral	0.33	neutral	0.64	disease	3	1	deleterious	0.18	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.15	medium_impact	-0.23	medium_impact	0.60	0.9	28.76	21.22	0.44	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9029	9029	A	T	MI.1070	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	503	168	H	L	cAc/cTc	4.52	0.99	0	probably_damaging	0.99	deleterious	0	neutral	4.05	deleterious	-5.27	deleterious	-9.7	high_impact	4.07	0.57	damaging	0.36	neutral	4.41	24.10	deleterious	0.22	0.65	0.9	disease	0.93	disease	0.73	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-1.4	low_impact	2.39	high_impact	0.38	0.9	48.23	8.83	0.5	P	0.96	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15861	15861	T	C	MI.10700	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1115	372	I	T	aTt/aCt	-2.12	0	0	benign	0.14	neutral	0.4	neutral	3.1	neutral	-1.64	neutral	-1.29	medium_impact	2.44	0.97	neutral	0.86	neutral	0.57	7.94	deleterious	0.05	0.35	NA	NA	0.35	neutral	0.45	neutral	0.16	neutral	7	0.53	neutral	0.63	deleterious	-3	neutral	0.26	neutral	0	medium_impact	0.13	medium_impact	1.02	medium_impact	0.16	0.8	19.47	32.29	0.37	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15862	15862	T	G	MI.10701	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1116	372	I	M	atT/atG	4.52	0.6	0.01	benign	0.34	neutral	0.29	neutral	3.09	neutral	-1.41	neutral	-0.17	low_impact	1.21	0.95	neutral	0.9	neutral	0.18	4.52	deleterious	0.22	0.45	NA	NA	0.21	neutral	0.17	neutral	0.2	neutral	6	0.65	neutral	0.48	deleterious	-6	neutral	0.28	neutral	-0.46	medium_impact	0.01	medium_impact	-0.1	medium_impact	0.58	0.8	19.47	32.29	0.46	N	0.66	polymorphism	1	0.01	rs386829263	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15862	15862	T	A	MI.10702	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1116	372	I	M	atT/atA	4.52	0.6	0.01	benign	0.34	neutral	0.29	neutral	3.09	neutral	-1.41	neutral	-0.17	low_impact	1.21	0.95	neutral	0.9	neutral	0.51	7.50	deleterious	0.22	0.45	NA	NA	0.21	neutral	0.17	neutral	0.2	neutral	6	0.65	neutral	0.48	deleterious	-6	neutral	0.28	neutral	-0.46	medium_impact	0.01	medium_impact	-0.1	medium_impact	0.58	0.8	19.47	32.29	0.46	N	0.66	polymorphism	1	0.01	rs386829263	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15863	15863	G	C	MI.10703	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1117	373	E	Q	Gaa/Caa	-5.33	0	0	probably_damaging	0.98	neutral	0.3	neutral	2.84	neutral	-2.63	neutral	-1.34	high_impact	3.56	0.91	neutral	0.11	damaging	1.74	14.61	neutral	0.18	0.45	NA	NA	0.68	disease	0.57	disease	0.65	disease	3	0.98	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	0.02	medium_impact	2.04	high_impact	0.52	0.8	58.95	7.85	0.31	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15863	15863	G	A	MI.10704	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1117	373	E	K	Gaa/Aaa	-5.33	0	0	probably_damaging	0.98	neutral	0.31	neutral	2.88	neutral	-1.97	neutral	-1.8	high_impact	3.56	0.95	neutral	0.09	damaging	2.91	21.90	deleterious	0.07	0.35	NA	NA	0.84	disease	0.64	disease	0.71	disease	4	0.98	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-2.31	low_impact	0.03	medium_impact	2.04	high_impact	0.66	0.8	58.95	7.85	0.32	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15864	15864	A	C	MI.10705	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1118	373	E	A	gAa/gCa	7.04	1	0	probably_damaging	0.98	neutral	0.51	neutral	2.85	neutral	-2.56	deleterious	-2.7	high_impact	4.53	0.94	neutral	0.15	damaging	2.19	17.45	deleterious	0.05	0.35	NA	NA	0.63	disease	0.67	disease	0.68	disease	4	0.98	deleterious	0.27	neutral	2	deleterious	0.81	deleterious	-2.31	low_impact	0.23	medium_impact	2.92	high_impact	0.28	0.8	58.95	7.85	0.53	N	0.83	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15864	15864	A	T	MI.10706	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1118	373	E	V	gAa/gTa	7.04	1	0	probably_damaging	0.99	neutral	0.5	neutral	2.8	deleterious	-4.3	deleterious	-3.15	high_impact	4.53	0.93	neutral	0.13	damaging	2.70	20.80	deleterious	0.03	0.35	NA	NA	0.82	disease	0.7	disease	0.74	disease	5	0.99	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0.22	medium_impact	2.92	high_impact	0.29	0.8	58.95	7.85	0.52	N	0.89	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15864	15864	A	G	MI.10707	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1118	373	E	G	gAa/gGa	7.04	1	0	probably_damaging	0.99	neutral	0.33	neutral	2.86	neutral	-2.31	deleterious	-3.14	medium_impact	3.11	0.96	neutral	0.19	damaging	4.00	23.60	deleterious	0.05	0.35	NA	NA	0.69	disease	0.69	disease	0.68	disease	4	0.99	deleterious	0.17	neutral	1	deleterious	0.83	deleterious	-2.59	low_impact	0.06	medium_impact	1.63	medium_impact	0.26	0.8	58.95	7.85	0.52	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15865	15865	A	C	MI.10708	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1119	373	E	D	gaA/gaC	6.59	1	0	probably_damaging	0.91	neutral	0.22	neutral	3	neutral	-0.89	neutral	-1.34	medium_impact	2.41	0.91	neutral	0.1	damaging	1.90	15.56	deleterious	0.26	0.45	NA	NA	0.64	disease	0.36	neutral	0.48	neutral	0	0.94	neutral	0.16	neutral	1	deleterious	0.78	deleterious	-1.67	low_impact	-0.08	medium_impact	1	medium_impact	0.58	0.8	58.95	7.85	0.52	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15865	15865	A	T	MI.10709	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1119	373	E	D	gaA/gaT	6.59	1	0	probably_damaging	0.91	neutral	0.22	neutral	3	neutral	-0.89	neutral	-1.34	medium_impact	2.41	0.91	neutral	0.1	damaging	2.03	16.40	deleterious	0.26	0.45	NA	NA	0.64	disease	0.36	neutral	0.48	neutral	0	0.94	neutral	0.16	neutral	1	deleterious	0.78	deleterious	-1.67	low_impact	-0.08	medium_impact	1	medium_impact	0.58	0.8	58.95	7.85	0.52	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9029	9029	A	C	MI.1071	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	503	168	H	P	cAc/cCc	4.52	0.99	0	probably_damaging	0.99	deleterious	0	neutral	4.04	deleterious	-5.89	deleterious	-8.85	high_impact	4.62	0.47	damaging	0.33	neutral	3.77	23.40	deleterious	0.2	0.65	0.93	disease	0.92	disease	0.81	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-2.65	low_impact	-1.4	low_impact	2.86	high_impact	0.33	0.9	48.23	8.83	0.62	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15866	15866	A	C	MI.10710	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1120	374	N	H	Aac/Cac	0.63	0.99	0	probably_damaging	1	neutral	0.53	neutral	2.94	neutral	-2.91	neutral	-2.15	high_impact	3.9	0.93	neutral	0.32	neutral	2.97	22.10	deleterious	0.33	0.5	NA	NA	0.66	disease	0.5	neutral	0.49	neutral	0	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.25	medium_impact	2.35	high_impact	0.19	0.8	43.95	14.15	0.34	N	0.38	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15866	15866	A	G	MI.10711	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1120	374	N	D	Aac/Gac	0.63	0.99	0	probably_damaging	0.98	neutral	0.39	neutral	3.02	neutral	-1.29	neutral	-2.06	medium_impact	2.5	0.93	neutral	0.88	neutral	1.07	11.03	neutral	0.45	0.55	NA	NA	0.51	disease	0.32	neutral	0.42	neutral	2	0.98	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-2.31	low_impact	0.12	medium_impact	1.08	medium_impact	0.33	0.8	43.95	14.15	0.42	N	0.03	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15866	15866	A	T	MI.10712	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1120	374	N	Y	Aac/Tac	0.63	0.99	0	probably_damaging	1	neutral	1	neutral	2.94	neutral	-2.82	deleterious	-3.51	high_impact	3.64	0.97	neutral	0.43	neutral	3.59	23.20	deleterious	0.09	0.35	NA	NA	0.77	disease	0.5	neutral	0.58	disease	2	1	deleterious	0.5	deleterious	2	deleterious	0.84	deleterious	-3.53	low_impact	1.85	high_impact	2.11	high_impact	0.16	0.8	43.95	14.15	0.31	N	0.93	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15867	15867	A	C	MI.10713	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1121	374	N	T	aAc/aCc	4.29	1	0	probably_damaging	0.99	neutral	0.45	neutral	2.98	neutral	-1.81	deleterious	-2.62	medium_impact	2.56	0.94	neutral	0.46	neutral	1.87	15.38	deleterious	0.23	0.45	NA	NA	0.68	disease	0.54	disease	0.6	disease	2	0.99	deleterious	0.23	neutral	1	deleterious	0.81	deleterious	-2.59	low_impact	0.18	medium_impact	1.13	medium_impact	0.31	0.8	43.95	14.15	0.44	N	0.55	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15867	15867	A	G	MI.10714	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1121	374	N	S	aAc/aGc	4.29	1	0	probably_damaging	0.95	neutral	0.56	neutral	3.03	neutral	-1.18	neutral	-2.18	high_impact	3.56	0.95	neutral	0.5	neutral	1.29	12.21	neutral	0.41	0.5	NA	NA	0.64	disease	0.36	neutral	0.47	neutral	1	0.95	neutral	0.31	neutral	2	deleterious	0.80	deleterious	-1.92	low_impact	0.28	medium_impact	2.04	high_impact	0.24	0.8	43.95	14.15	0.4	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15867	15867	A	T	MI.10715	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1121	374	N	I	aAc/aTc	4.29	1	0	probably_damaging	1	neutral	0.44	neutral	2.92	deleterious	-4.15	deleterious	-3.97	high_impact	4.45	0.94	neutral	0.41	neutral	3.84	23.40	deleterious	0.11	0.4	NA	NA	0.83	disease	0.53	disease	0.71	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.17	medium_impact	2.85	high_impact	0.13	0.8	43.95	14.15	0.53	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15868	15868	C	A	MI.10716	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1122	374	N	K	aaC/aaA	8.42	1	0	probably_damaging	1	neutral	0.52	neutral	3.1	neutral	-0.46	deleterious	-2.62	medium_impact	2	0.94	neutral	0.31	neutral	4.50	24.30	deleterious	0.28	0.45	NA	NA	0.73	disease	0.31	neutral	0.5	disease	0	1	deleterious	0.26	neutral	1	deleterious	0.84	deleterious	-3.53	low_impact	0.24	medium_impact	0.62	medium_impact	0.41	0.8	43.95	14.15	0.46	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15868	15868	C	G	MI.10717	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1122	374	N	K	aaC/aaG	8.42	1	0	probably_damaging	1	neutral	0.52	neutral	3.1	neutral	-0.46	deleterious	-2.62	medium_impact	2	0.94	neutral	0.31	neutral	4.04	23.70	deleterious	0.28	0.45	NA	NA	0.73	disease	0.31	neutral	0.5	disease	0	1	deleterious	0.26	neutral	1	deleterious	0.84	deleterious	-3.53	low_impact	0.24	medium_impact	0.62	medium_impact	0.41	0.8	43.95	14.15	0.46	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15869	15869	A	C	MI.10718	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1123	375	K	Q	Aaa/Caa	-1.44	0	0	benign	0.03	neutral	0.31	neutral	3.08	neutral	-1.36	neutral	-1.47	medium_impact	2.94	0.96	neutral	0.74	neutral	1.61	13.93	neutral	0.35	0.5	NA	NA	0.58	disease	0.45	neutral	0.46	neutral	1	0.67	neutral	0.64	deleterious	-3	neutral	0.19	neutral	0.68	medium_impact	0.03	medium_impact	1.48	medium_impact	0.34	0.8	19.21	24.09	0.35	N	0.56	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15869	15869	A	G	MI.10719	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1123	375	K	E	Aaa/Gaa	-1.44	0	0	benign	0.02	neutral	0.32	neutral	3.08	neutral	-0.9	neutral	-1.49	medium_impact	3.43	0.92	neutral	0.22	damaging	2.18	17.41	deleterious	0.21	0.45	NA	NA	0.69	disease	0.53	disease	0.54	disease	1	0.67	neutral	0.65	deleterious	-3	neutral	0.22	neutral	0.85	medium_impact	0.05	medium_impact	1.92	medium_impact	0.49	0.8	19.21	24.09	0.29	N	0.48	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9029	9029	A	G	MI.1072	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	503	168	H	R	cAc/cGc	4.52	0.99	0	probably_damaging	0.99	deleterious	0	neutral	4.07	deleterious	-4.68	deleterious	-7.02	high_impact	4.62	0.44	damaging	0.29	neutral	3.56	23.10	deleterious	0.37	0.65	0.86	disease	0.9	disease	0.78	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.65	low_impact	-1.4	low_impact	2.86	high_impact	0.30	0.9	48.23	8.83	0.72	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15870	15870	A	T	MI.10720	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1124	375	K	M	aAa/aTa	0.17	0	0	benign	0.35	neutral	0.24	neutral	3.09	neutral	-2.81	neutral	-2.21	medium_impact	2.94	0.96	neutral	0.4	neutral	3.89	23.50	deleterious	0.11	0.4	NA	NA	0.59	disease	0.27	neutral	0.47	neutral	1	0.71	neutral	0.45	neutral	-3	neutral	0.39	neutral	-0.48	medium_impact	-0.05	medium_impact	1.48	medium_impact	0.22	0.8	19.21	24.09	0.39	N	0.65	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15870	15870	A	C	MI.10721	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1124	375	K	T	aAa/aCa	0.17	0	0	benign	0.13	neutral	0.41	neutral	3.15	neutral	-1.07	neutral	-2.08	medium_impact	2.7	0.96	neutral	0.33	neutral	2.24	17.80	deleterious	0.17	0.45	NA	NA	0.61	disease	0.46	neutral	0.46	neutral	1	0.52	neutral	0.64	deleterious	-3	neutral	0.27	neutral	0.04	medium_impact	0.14	medium_impact	1.26	medium_impact	0.18	0.8	19.21	24.09	0.3	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15871	15871	A	T	MI.10722	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1125	375	K	N	aaA/aaT	2.92	0.02	0	benign	0.07	neutral	0.47	neutral	3.08	neutral	-1.64	neutral	-1.67	low_impact	1.13	0.96	neutral	0.88	neutral	1.19	11.72	neutral	0.46	0.55	NA	NA	0.45	neutral	0.31	neutral	0.21	neutral	6	0.47	neutral	0.7	deleterious	-6	neutral	0.23	neutral	0.32	medium_impact	0.19	medium_impact	-0.17	medium_impact	0.37	0.8	19.21	24.09	0.33	N	0.01	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15871	15871	A	C	MI.10723	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1125	375	K	N	aaA/aaC	2.92	0.02	0	benign	0.07	neutral	0.47	neutral	3.08	neutral	-1.64	neutral	-1.67	low_impact	1.13	0.96	neutral	0.88	neutral	1.14	11.42	neutral	0.46	0.55	NA	NA	0.45	neutral	0.31	neutral	0.21	neutral	6	0.47	neutral	0.7	deleterious	-6	neutral	0.23	neutral	0.32	medium_impact	0.19	medium_impact	-0.17	medium_impact	0.37	0.8	19.21	24.09	0.33	N	0.01	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15872	15872	A	C	MI.10724	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1126	376	M	L	Ata/Cta	-2.12	0	0	possibly_damaging	0.63	neutral	0.78	neutral	3.35	neutral	1.6	neutral	-0.11	neutral_impact	-0.9	0.98	neutral	0.98	neutral	-1.16	0.01	neutral	0.38	0.5	NA	NA	0.08	neutral	0.24	neutral	0.18	neutral	6	0.56	neutral	0.58	deleterious	-3	neutral	0.38	neutral	-0.95	medium_impact	0.52	medium_impact	-2.01	low_impact	0.29	0.8	16.58	27.37	0.39	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15872	15872	A	T	MI.10725	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1126	376	M	L	Ata/Tta	-2.12	0	0	possibly_damaging	0.63	neutral	0.78	neutral	3.35	neutral	1.6	neutral	-0.11	neutral_impact	-0.9	0.98	neutral	0.98	neutral	-1.09	0.01	neutral	0.38	0.5	NA	NA	0.08	neutral	0.24	neutral	0.18	neutral	6	0.56	neutral	0.58	deleterious	-3	neutral	0.38	neutral	-0.95	medium_impact	0.52	medium_impact	-2.01	low_impact	0.29	0.8	16.58	27.37	0.39	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15872	15872	A	G	MI.10726	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1126	376	M	V	Ata/Gta	-2.12	0	0	possibly_damaging	0.73	neutral	0.49	neutral	3.19	neutral	0.32	neutral	-0.48	low_impact	1.66	0.97	neutral	0.67	neutral	-0.03	2.31	deleterious	0.37	0.5	NA	NA	0.24	neutral	0.5	neutral	0.17	neutral	7	0.71	neutral	0.38	neutral	-3	neutral	0.53	deleterious	-1.13	low_impact	0.21	medium_impact	0.31	medium_impact	0.20	0.8	16.58	27.37	0.37	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15873	15873	T	C	MI.10727	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1127	376	M	T	aTa/aCa	-3.73	0	0	probably_damaging	0.94	neutral	0.39	neutral	3.15	neutral	-0.35	neutral	-0.95	medium_impact	2.55	0.95	neutral	0.53	neutral	0.38	6.44	deleterious	0.16	0.45	NA	NA	0.29	neutral	0.42	neutral	0.17	neutral	7	0.94	neutral	0.23	neutral	1	deleterious	0.68	deleterious	-1.85	low_impact	0.12	medium_impact	1.12	medium_impact	0.11	0.8	16.58	27.37	0.37	N	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15873	15873	T	A	MI.10728	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1127	376	M	K	aTa/aAa	-3.73	0	0	possibly_damaging	0.87	neutral	0.39	neutral	3.16	neutral	-0.13	neutral	-1.51	medium_impact	2.29	0.95	neutral	0.43	neutral	2.56	19.88	deleterious	0.1	0.4	NA	NA	0.52	disease	0.43	neutral	0.53	disease	1	0.87	neutral	0.26	neutral	0	NA	0.71	deleterious	-1.5	low_impact	0.12	medium_impact	0.89	medium_impact	0.24	0.8	16.58	27.37	0.3	N	0.93	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15874	15874	A	C	MI.10729	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1128	376	M	I	atA/atC	2	0.02	0.09	possibly_damaging	0.8	neutral	0.42	neutral	3.21	neutral	0.52	neutral	-0.43	neutral_impact	0.32	0.97	neutral	0.82	neutral	0.42	6.80	deleterious	0.32	0.5	NA	NA	0.17	neutral	0.25	neutral	0.22	neutral	6	0.8	neutral	0.31	neutral	-3	neutral	0.56	deleterious	-1.29	low_impact	0.15	medium_impact	-0.9	medium_impact	0.24	0.8	16.58	27.37	0.42	N	0.41	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9030	9030	C	A	MI.1073	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	504	168	H	Q	caC/caA	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	4.08	deleterious	-4.35	deleterious	-7.02	high_impact	4.07	0.56	damaging	0.33	neutral	4.00	23.60	deleterious	0.44	0.65	0.85	disease	0.88	disease	0.72	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-1.4	low_impact	2.39	high_impact	0.42	0.9	48.23	8.83	0.48	N	0.95	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15874	15874	A	T	MI.10730	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1128	376	M	I	atA/atT	2	0.02	0.09	possibly_damaging	0.8	neutral	0.42	neutral	3.21	neutral	0.52	neutral	-0.43	neutral_impact	0.32	0.97	neutral	0.82	neutral	0.47	7.20	deleterious	0.32	0.5	NA	NA	0.17	neutral	0.25	neutral	0.22	neutral	6	0.8	neutral	0.31	neutral	-3	neutral	0.56	deleterious	-1.29	low_impact	0.15	medium_impact	-0.9	medium_impact	0.24	0.8	16.58	27.37	0.42	N	0.41	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15875	15875	C	G	MI.10731	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1129	377	L	V	Ctc/Gtc	-10.6	0	0	probably_damaging	0.95	neutral	0.48	neutral	3.05	neutral	-0.81	neutral	-1.12	medium_impact	3.12	0.96	neutral	0.13	damaging	1.92	15.70	deleterious	0.31	0.45	NA	NA	0.32	neutral	0.37	neutral	0.18	neutral	6	0.95	neutral	0.27	neutral	1	deleterious	0.71	deleterious	-1.92	low_impact	0.2	medium_impact	1.64	medium_impact	0.29	0.8	29.74	16.44	0.33	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15875	15875	C	A	MI.10732	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1129	377	L	I	Ctc/Atc	-10.6	0	0	probably_damaging	0.98	neutral	0.49	neutral	3.04	neutral	-0.86	neutral	-0.76	medium_impact	2.21	0.97	neutral	0.31	neutral	2.69	20.70	deleterious	0.32	0.5	NA	NA	0.29	neutral	0.17	neutral	0.2	neutral	6	0.98	deleterious	0.26	neutral	1	deleterious	0.71	deleterious	-2.31	low_impact	0.21	medium_impact	0.81	medium_impact	0.42	0.8	29.74	16.44	0.39	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15875	15875	C	T	MI.10733	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1129	377	L	F	Ctc/Ttc	-10.6	0	0	probably_damaging	0.99	neutral	0.74	neutral	3.02	neutral	-2.33	neutral	-1.48	medium_impact	2.54	0.96	neutral	0.14	damaging	3.94	23.50	deleterious	0.31	0.45	NA	NA	0.36	neutral	0.23	neutral	0.2	neutral	6	0.99	deleterious	0.38	neutral	1	deleterious	0.75	deleterious	-2.59	low_impact	0.47	medium_impact	1.11	medium_impact	0.39	0.8	29.74	16.44	0.24	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15876	15876	T	G	MI.10734	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1130	377	L	R	cTc/cGc	-0.98	0	0	probably_damaging	1	neutral	0.32	neutral	2.99	deleterious	-3.17	neutral	-2.29	high_impact	3.87	0.95	neutral	0.07	damaging	4.32	24.00	deleterious	0.04	0.35	NA	NA	0.68	disease	0.5	neutral	0.48	neutral	0	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.05	medium_impact	2.32	high_impact	0.14	0.8	29.74	16.44	0.34	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15876	15876	T	C	MI.10735	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1130	377	L	P	cTc/cCc	-0.98	0	0	probably_damaging	1	neutral	0.19	neutral	3.01	deleterious	-4.25	deleterious	-2.71	medium_impact	3.31	0.95	neutral	0.08	damaging	4.20	23.90	deleterious	0.04	0.35	NA	NA	0.63	disease	0.64	disease	0.66	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.85	deleterious	-3.53	low_impact	-0.12	medium_impact	1.81	medium_impact	0.11	0.8	29.74	16.44	0.35	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15876	15876	T	A	MI.10736	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1130	377	L	H	cTc/cAc	-0.98	0	0	probably_damaging	1	neutral	0.5	neutral	2.97	deleterious	-4.18	deleterious	-2.64	high_impact	4.21	0.94	neutral	0.09	damaging	4.48	24.20	deleterious	0.07	0.35	NA	NA	0.53	disease	0.31	neutral	0.47	neutral	1	1	deleterious	0.25	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.22	medium_impact	2.63	high_impact	0.24	0.8	29.74	16.44	0.32	N	0.95	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15878	15878	A	C	MI.10737	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1132	378	K	Q	Aaa/Caa	-1.21	0	0	probably_damaging	0.94	neutral	0.45	neutral	3.09	neutral	-1.09	neutral	-0.93	medium_impact	2.6	0.96	neutral	0.44	neutral	1.79	14.92	neutral	0.53	0.6	NA	NA	0.32	neutral	0.25	neutral	0.2	neutral	6	0.93	neutral	0.26	neutral	1	deleterious	0.68	deleterious	-1.85	low_impact	0.18	medium_impact	1.17	medium_impact	0.54	0.8	37.11	17.49	0.4	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15878	15878	A	G	MI.10738	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1132	378	K	E	Aaa/Gaa	-1.21	0	0	probably_damaging	0.94	neutral	0.55	neutral	3.12	neutral	-0.43	neutral	-0.86	medium_impact	2.5	0.96	neutral	0.45	neutral	2.35	18.48	deleterious	0.31	0.45	NA	NA	0.41	neutral	0.4	neutral	0.17	neutral	7	0.93	neutral	0.31	neutral	1	deleterious	0.73	deleterious	-1.85	low_impact	0.27	medium_impact	1.08	medium_impact	0.70	0.85	37.11	17.49	0.29	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15879	15879	A	T	MI.10739	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1133	378	K	M	aAa/aTa	0.4	0.09	0	probably_damaging	0.99	neutral	0.25	neutral	3.06	neutral	-2.62	neutral	-1.71	medium_impact	3.5	0.95	neutral	0.45	neutral	3.81	23.40	deleterious	0.22	0.45	NA	NA	0.4	neutral	0.26	neutral	0.22	neutral	6	0.99	deleterious	0.13	neutral	1	deleterious	0.70	deleterious	-2.59	low_impact	-0.04	medium_impact	1.98	medium_impact	0.18	0.8	37.11	17.49	0.5	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9030	9030	C	G	MI.1074	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	504	168	H	Q	caC/caG	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	4.08	deleterious	-4.35	deleterious	-7.02	high_impact	4.07	0.56	damaging	0.33	neutral	3.67	23.30	deleterious	0.44	0.65	0.85	disease	0.88	disease	0.72	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-1.4	low_impact	2.39	high_impact	0.42	0.9	48.23	8.83	0.47	N	0.95	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15879	15879	A	C	MI.10740	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1133	378	K	T	aAa/aCa	0.4	0.09	0	probably_damaging	0.98	neutral	0.54	neutral	3.11	neutral	-1.09	neutral	-1.51	high_impact	3.85	0.95	neutral	0.46	neutral	2.22	17.62	deleterious	0.34	0.5	NA	NA	0.41	neutral	0.39	neutral	0.19	neutral	6	0.98	neutral	0.28	neutral	2	deleterious	0.73	deleterious	-2.31	low_impact	0.26	medium_impact	2.3	high_impact	0.14	0.8	37.11	17.49	0.34	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15880	15880	A	T	MI.10741	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1134	378	K	N	aaA/aaT	5.44	0.87	0	probably_damaging	0.99	neutral	0.44	neutral	3.14	neutral	-1.07	neutral	-0.76	low_impact	1.77	0.94	neutral	0.6	neutral	1.29	12.22	neutral	0.7	0.75	NA	NA	0.17	neutral	0.22	neutral	0.25	neutral	5	0.99	deleterious	0.23	neutral	-2	neutral	0.70	deleterious	-2.59	low_impact	0.17	medium_impact	0.41	medium_impact	0.32	0.8	37.11	17.49	0.47	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15880	15880	A	C	MI.10742	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1134	378	K	N	aaA/aaC	5.44	0.87	0	probably_damaging	0.99	neutral	0.44	neutral	3.14	neutral	-1.07	neutral	-0.76	low_impact	1.77	0.94	neutral	0.6	neutral	1.25	12.03	neutral	0.7	0.75	NA	NA	0.17	neutral	0.22	neutral	0.25	neutral	5	0.99	deleterious	0.23	neutral	-2	neutral	0.70	deleterious	-2.59	low_impact	0.17	medium_impact	0.41	medium_impact	0.32	0.8	37.11	17.49	0.48	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15881	15881	T	C	MI.10743	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1135	379	W	R	Tgg/Cgg	-0.06	0.77	0	probably_damaging	1	neutral	0.35	neutral	3.16	neutral	-0.16	deleterious	-2.9	medium_impact	3.16	0.68	neutral	0.07	damaging	3.59	23.20	deleterious	0.17	0.45	NA	NA	0.58	disease	0.51	disease	0.53	disease	1	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.53	low_impact	0.08	medium_impact	1.68	medium_impact	0.14	0.8	NA	NA	0.28	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	COSM5656137	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15881	15881	T	G	MI.10744	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1135	379	W	G	Tgg/Ggg	-0.06	0.77	0	probably_damaging	0.99	neutral	0.33	neutral	3.14	neutral	-0.65	deleterious	-2.86	medium_impact	3.36	0.81	neutral	0.15	damaging	2.51	19.53	deleterious	0.14	0.4	NA	NA	0.49	neutral	0.59	disease	0.5	neutral	0	0.99	deleterious	0.17	neutral	1	deleterious	0.76	deleterious	-2.59	low_impact	0.06	medium_impact	1.86	medium_impact	0.14	0.8	NA	NA	0.28	N	0.90	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15882	15882	G	C	MI.10745	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1136	379	W	S	tGg/tCg	4.52	0.87	0	probably_damaging	1	neutral	0.41	neutral	3.17	neutral	0.08	deleterious	-2.86	medium_impact	2.67	0.8	neutral	0.12	damaging	3.80	23.40	deleterious	0.15	0.45	NA	NA	0.6	disease	0.5	neutral	0.52	disease	0	1	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.14	medium_impact	1.23	medium_impact	0.13	0.8	NA	NA	0.29	N	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15882	15882	G	T	MI.10746	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1136	379	W	L	tGg/tTg	4.52	0.87	0	probably_damaging	0.99	neutral	0.66	neutral	3.29	neutral	1.45	neutral	-2.24	low_impact	1.18	0.81	neutral	0.1	damaging	2.78	21.30	deleterious	0.18	0.45	NA	NA	0.41	neutral	0.51	disease	0.23	neutral	5	0.99	deleterious	0.34	neutral	-2	neutral	0.75	deleterious	-2.59	low_impact	0.38	medium_impact	-0.12	medium_impact	0.17	0.8	NA	NA	0.3	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15883	15883	G	C	MI.10747	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1137	379	W	C	tgG/tgC	-0.52	0.05	0.02	probably_damaging	1	neutral	0.18	neutral	3.12	neutral	-1.8	deleterious	-2.62	medium_impact	3.36	0.83	neutral	0.06	damaging	4.06	23.70	deleterious	0.13	0.4	NA	NA	0.53	disease	0.59	disease	0.65	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	-0.14	medium_impact	1.86	medium_impact	0.09	0.8	NA	NA	0.29	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15883	15883	G	T	MI.10748	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1137	379	W	C	tgG/tgT	-0.52	0.05	0.02	probably_damaging	1	neutral	0.18	neutral	3.12	neutral	-1.8	deleterious	-2.62	medium_impact	3.36	0.83	neutral	0.06	damaging	4.22	23.90	deleterious	0.13	0.4	NA	NA	0.53	disease	0.59	disease	0.65	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	-0.14	medium_impact	1.86	medium_impact	0.09	0.8	NA	NA	0.29	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15884	15884	G	T	MI.10749	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1138	380	A	S	Gcc/Tcc	3.61	0.12	0.1	possibly_damaging	0.52	neutral	0.42	neutral	4.63	neutral	-0.51	neutral	-0.04	neutral_impact	0.34	0.99	neutral	0.86	neutral	0.44	6.91	deleterious	0.28	0.45	NA	NA	0.03	neutral	0.17	neutral	0.11	neutral	8	0.57	neutral	0.45	neutral	-3	neutral	0.05	neutral	-0.76	medium_impact	0.15	medium_impact	-0.89	medium_impact	0.48	0.8	NA	NA	0.6	P	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9031	9031	C	G	MI.1075	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	505	169	L	V	Cta/Gta	-4.5	0	0	probably_damaging	0.99	neutral	0.08	neutral	4.11	neutral	-1.26	deleterious	-2.63	medium_impact	2.68	0.31	damaging	0.47	neutral	3.47	23.00	deleterious	0.34	0.65	0.54	disease	0.61	disease	0.55	disease	0.62	disease	2	1	deleterious	0.05	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	-0.31	medium_impact	1.2	medium_impact	0.65	0.9	50.88	8.57	0.63	P	0.87	polymorphism	0.63	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15884	15884	G	A	MI.10750	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1138	380	A	T	Gcc/Acc	3.61	0.12	0.1	possibly_damaging	0.52	neutral	0.4	neutral	4.6	neutral	-0.83	neutral	-0.01	neutral_impact	-0.34	1	neutral	0.78	neutral	3.98	23.60	deleterious	0.2	0.45	NA	NA	0.18	neutral	0.44	neutral	0.26	neutral	5	0.59	neutral	0.44	neutral	-3	neutral	0.04	neutral	-0.76	medium_impact	0.13	medium_impact	-1.5	low_impact	0.50	0.8	NA	NA	0.58	P	0.05	polymorphism	1	0.01	rs527236195	Likely_pathogenic	Neoplasm_of_ovary	153625	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15884	15884	G	C	MI.10751	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1138	380	A	P	Gcc/Ccc	3.61	0.12	0.1	possibly_damaging	0.75	neutral	0.21	neutral	4.55	neutral	-1.65	neutral	-0.3	neutral_impact	0.7	1	neutral	0.34	neutral	3.78	23.40	deleterious	0.18	0.45	NA	NA	0.43	neutral	0.44	neutral	0.27	neutral	5	0.85	neutral	0.23	neutral	-3	neutral	0.13	neutral	-1.18	low_impact	-0.09	medium_impact	-0.56	medium_impact	0.37	0.8	NA	NA	0.56	N	0.09	polymorphism	1	0.01	rs527236195	Benign	not_specified	247210	MedGen:CN169374	pancreatic cancer cell line	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15885	15885	C	T	MI.10752	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1139	380	A	V	gCc/gTc	0.4	0.01	0	possibly_damaging	0.52	neutral	0.5	neutral	4.64	neutral	-0.32	neutral	-0.27	neutral_impact	0.14	0.99	neutral	0.78	neutral	4.30	24.00	deleterious	0.21	0.45	NA	NA	0.2	neutral	0.46	neutral	0.27	neutral	5	0.52	neutral	0.49	deleterious	-3	neutral	0.06	neutral	-0.76	medium_impact	0.22	medium_impact	-1.07	low_impact	0.50	0.8	NA	NA	0.45	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15885	15885	C	G	MI.10753	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1139	380	A	G	gCc/gGc	0.4	0.01	0	possibly_damaging	0.52	neutral	0.34	neutral	4.59	neutral	-0.65	neutral	-0.27	neutral_impact	0.7	1	neutral	0.8	neutral	2.44	19.08	deleterious	0.23	0.45	NA	NA	0.16	neutral	0.42	neutral	0.24	neutral	5	0.64	neutral	0.41	neutral	-3	neutral	0.04	neutral	-0.76	medium_impact	0.07	medium_impact	-0.56	medium_impact	0.39	0.8	NA	NA	0.51	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15885	15885	C	A	MI.10754	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1139	380	A	D	gCc/gAc	0.4	0.01	0	possibly_damaging	0.75	neutral	0.21	neutral	4.57	neutral	-1.02	neutral	-0.28	neutral_impact	0.7	1	neutral	0.44	neutral	4.44	24.20	deleterious	0.2	0.45	NA	NA	0.43	neutral	0.51	disease	0.3	neutral	4	0.85	neutral	0.23	neutral	-3	neutral	0.09	neutral	-1.18	low_impact	-0.09	medium_impact	-0.56	medium_impact	0.28	0.8	NA	NA	0.51	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3307	3307	A	C	MI.10755	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	1	1	M	L	Ata/Cta	-4.38	0	0	probably_damaging	0.93	deleterious	0	neutral	2.95	neutral	1.34	neutral	-0.72	NA	NA	0.69	neutral	0.19	damaging	1.01	10.73	neutral	0.06	0.35	NA	NA	0.12	neutral	0.16	neutral	0.16	neutral	7	1	deleterious	0.04	neutral	4	deleterious	0.67	deleterious	NA	NA	NA	NA	NA	NA	0.38	0.8	56.92	9.83	0.52	P	0.44	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3307	3307	A	T	MI.10756	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	1	1	M	L	Ata/Tta	-4.38	0	0	probably_damaging	0.93	deleterious	0	neutral	2.95	neutral	1.34	neutral	-0.72	NA	NA	0.69	neutral	0.19	damaging	1.09	11.15	neutral	0.06	0.35	NA	NA	0.12	neutral	0.16	neutral	0.16	neutral	7	1	deleterious	0.04	neutral	4	deleterious	0.67	deleterious	NA	NA	NA	NA	NA	NA	0.38	0.8	56.92	9.83	0.52	P	0.44	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3307	3307	A	G	MI.10757	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	1	1	M	V	Ata/Gta	-4.38	0	0	probably_damaging	0.97	deleterious	0	neutral	2.89	neutral	0.91	neutral	-0.88	NA	NA	0.61	neutral	0.2	damaging	0.74	9.08	deleterious	0.08	0.35	NA	NA	0.17	neutral	0.41	neutral	0.18	neutral	6	1	deleterious	0.02	neutral	4	deleterious	0.70	deleterious	NA	NA	NA	NA	NA	NA	0.26	0.8	56.92	9.83	0.36	N	0.07	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3308	3308	T	C	MI.10758	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	2	1	M	T	aTa/aCa	3.67	0.98	0.01	probably_damaging	0.99	deleterious	0	neutral	2.8	neutral	-0.17	neutral	-0.26	NA	NA	0.53	damaging	0.2	damaging	2.36	18.57	deleterious	0.07	0.35	NA	NA	0.28	neutral	0.51	disease	0.24	neutral	5	1	deleterious	0.01	neutral	4	deleterious	0.74	deleterious	NA	NA	NA	NA	NA	NA	0.08	0.8	56.92	9.83	0.75	P	0.05	NA	NA	0.01	rs28358582	Likely_benign	SUDDEN_INFANT_DEATH_SYNDROME|Carcinoma_of_colon|not_specified	24767	EFO:EFO_0005303,MedGen:C0038644,OMIM:272120,SNOMED_CT:51178009|MedGen:C0699790,OMIM:114500,SNOMED_CT:269533000|MedGen:CN169374	colorectal tumor	.	.	.	T3308C	MELAS / DEAF enhancer / hypertension / LVNC / putative LHON	-	+	P.M.-possibly synergistic	14	P	N	P,N	neutral
chrM	3308	3308	T	A	MI.10759	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	2	1	M	K	aTa/aAa	3.67	0.98	0.01	probably_damaging	0.99	deleterious	0	neutral	2.81	neutral	-0.08	neutral	-1.86	NA	NA	0.52	damaging	0.15	damaging	3.39	23.00	deleterious	0.06	0.35	NA	NA	0.43	neutral	0.54	disease	0.32	neutral	4	1	deleterious	0.01	neutral	4	deleterious	0.76	deleterious	NA	NA	NA	NA	NA	NA	0.17	0.8	56.92	9.83	0.71	P	0.79	NA	NA	0.02	rs28358582	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	9031	9031	C	A	MI.1076	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	505	169	L	M	Cta/Ata	-4.5	0	0	probably_damaging	1	neutral	0.09	neutral	3.91	deleterious	-3.77	neutral	-1.68	medium_impact	2.92	0.57	damaging	0.62	neutral	3.98	23.60	deleterious	0.29	0.65	0.59	disease	0.61	disease	0.54	disease	0.53	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.28	medium_impact	1.41	medium_impact	0.59	0.9	50.88	8.57	0.35	N	0.96	polymorphism	0.68	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3309	3309	A	T	MI.10760	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	3	1	M	I	atA/atT	4.58	1	0	probably_damaging	0.98	deleterious	0	neutral	2.88	neutral	0.75	neutral	-1.01	NA	NA	0.57	damaging	0.16	damaging	1.67	14.21	neutral	0.07	0.35	NA	NA	0.2	neutral	0.17	neutral	0.2	neutral	6	1	deleterious	0.01	neutral	4	deleterious	0.73	deleterious	NA	NA	NA	NA	NA	NA	0.46	0.8	56.92	9.83	0.63	P	0.37	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3309	3309	A	C	MI.10761	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	3	1	M	I	atA/atC	4.58	1	0	probably_damaging	0.98	deleterious	0	neutral	2.88	neutral	0.75	neutral	-1.01	NA	NA	0.57	damaging	0.16	damaging	1.58	13.73	neutral	0.07	0.35	NA	NA	0.2	neutral	0.17	neutral	0.2	neutral	6	1	deleterious	0.01	neutral	4	deleterious	0.73	deleterious	NA	NA	NA	NA	NA	NA	0.46	0.8	56.92	9.83	0.63	P	0.37	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3310	3310	C	T	MI.10762	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	4	2	P	S	Ccc/Tcc	2.75	1	0	benign	0.11	neutral	0.34	neutral	2.85	neutral	1.08	neutral	0.74	neutral_impact	0	0.9	neutral	0.81	neutral	2.45	19.15	deleterious	0.25	0.45	NA	NA	0.05	neutral	0.12	neutral	0.09	neutral	8	0.61	neutral	0.62	deleterious	-6	neutral	0.15	neutral	0.1	medium_impact	0.11	medium_impact	-1.19	low_impact	0.35	0.8	26.42	27.76	0.69	P	0.55	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	C3310T	Diabetes / HCM	+	+	Reported	3	.	P	P	neutral
chrM	3310	3310	C	A	MI.10763	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	4	2	P	T	Ccc/Acc	2.75	1	0	benign	0	neutral	0.47	neutral	2.88	neutral	1.52	neutral	0.82	neutral_impact	0	0.86	neutral	0.79	neutral	1.98	16.08	deleterious	0.21	0.45	NA	NA	0.05	neutral	0.22	neutral	0.1	neutral	8	0.53	neutral	0.74	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	0.25	medium_impact	-1.19	low_impact	0.50	0.8	26.42	27.76	0.53	P	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3310	3310	C	G	MI.10764	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	4	2	P	A	Ccc/Gcc	2.75	1	0	benign	0.11	neutral	0.39	neutral	2.88	neutral	1.48	neutral	0.5	neutral_impact	0	0.88	neutral	0.75	neutral	1.65	14.15	neutral	0.21	0.45	NA	NA	0.05	neutral	0.24	neutral	0.11	neutral	8	0.55	neutral	0.64	deleterious	-6	neutral	0.12	neutral	0.1	medium_impact	0.17	medium_impact	-1.19	low_impact	0.58	0.8	26.42	27.76	0.55	P	0.52	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3311	3311	C	A	MI.10765	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	5	2	P	H	cCc/cAc	-1.85	0	0	benign	0.01	neutral	0.34	neutral	2.81	neutral	0.05	neutral	3.08	neutral_impact	0	0.92	neutral	0.85	neutral	2.45	19.12	deleterious	0.16	0.45	NA	NA	0.09	neutral	0.18	neutral	0.11	neutral	8	0.65	neutral	0.67	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.11	medium_impact	-1.19	low_impact	0.36	0.8	26.42	27.76	0.5	N	0.55	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3311	3311	C	T	MI.10766	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	5	2	P	L	cCc/cTc	-1.85	0	0	benign	0.01	neutral	1	neutral	2.97	neutral	2.38	neutral	1.03	neutral_impact	0	0.93	neutral	0.75	neutral	2.52	19.60	deleterious	0.18	0.45	NA	NA	0.1	neutral	0.26	neutral	0.14	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	1.96	high_impact	-1.19	low_impact	0.58	0.8	26.42	27.76	0.32	N	0.51	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3311	3311	C	G	MI.10767	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	5	2	P	R	cCc/cGc	-1.85	0	0	benign	0.32	neutral	0.21	neutral	2.81	neutral	0.09	neutral	0.42	neutral_impact	0	0.83	neutral	0.51	neutral	2.24	17.79	deleterious	0.15	0.4	NA	NA	0.19	neutral	0.34	neutral	0.2	neutral	6	0.75	neutral	0.45	neutral	-6	neutral	0.34	neutral	-0.44	medium_impact	-0.05	medium_impact	-1.19	low_impact	0.36	0.8	26.42	27.76	0.41	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3313	3313	A	G	MI.10768	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	7	3	M	V	Atg/Gtg	-5.98	0	0	benign	0	neutral	0.67	neutral	2.96	neutral	0.7	neutral	0.28	neutral_impact	0	0.97	neutral	0.88	neutral	-0.28	0.73	neutral	0.32	0.5	NA	NA	0.14	neutral	0.32	neutral	0.2	neutral	6	0.32	neutral	0.84	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.45	medium_impact	-1.19	low_impact	0.18	0.8	30.5	43.29	0.32	N	0.30	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3313	3313	A	T	MI.10769	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	7	3	M	L	Atg/Ttg	-5.98	0	0	benign	0.03	neutral	0.9	neutral	3.11	neutral	1.95	neutral	0.56	neutral_impact	0	0.98	neutral	0.97	neutral	-1.25	0.01	neutral	0.24	0.45	NA	NA	0.06	neutral	0.26	neutral	0.12	neutral	8	0.04	neutral	0.94	deleterious	-6	neutral	0.09	neutral	0.67	medium_impact	0.81	medium_impact	-1.19	low_impact	0.22	0.8	30.5	43.29	0.4	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9032	9032	T	G	MI.1077	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	506	169	L	R	cTa/cGa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	3.88	deleterious	-5.06	deleterious	-5.27	high_impact	4.37	0.24	damaging	0.38	neutral	4.29	24.00	deleterious	0.11	0.65	0.89	disease	0.88	disease	0.74	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.65	high_impact	0.59	0.9	50.88	8.57	0.92	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3313	3313	A	C	MI.10770	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	7	3	M	L	Atg/Ctg	-5.98	0	0	benign	0.03	neutral	0.9	neutral	3.11	neutral	1.95	neutral	0.56	neutral_impact	0	0.98	neutral	0.97	neutral	-1.30	0.01	neutral	0.24	0.45	NA	NA	0.06	neutral	0.26	neutral	0.12	neutral	8	0.04	neutral	0.94	deleterious	-6	neutral	0.09	neutral	0.67	medium_impact	0.81	medium_impact	-1.19	low_impact	0.22	0.8	30.5	43.29	0.39	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3314	3314	T	C	MI.10771	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	8	3	M	T	aTg/aCg	-4.15	0	0	benign	0	neutral	0.49	neutral	2.79	neutral	-0.8	neutral	-1.78	neutral_impact	0	0.86	neutral	0.79	neutral	-0.28	0.72	neutral	0.19	0.45	NA	NA	0.18	neutral	0.53	disease	0.27	neutral	5	0.51	neutral	0.75	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.27	medium_impact	-1.19	low_impact	0.08	0.8	30.5	43.29	0.35	N	0.04	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3314	3314	T	A	MI.10772	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	8	3	M	K	aTg/aAg	-4.15	0	0	benign	0.11	neutral	0.26	neutral	2.77	neutral	-1.38	deleterious	-3.16	neutral_impact	0	0.79	neutral	0.48	neutral	2.05	16.54	deleterious	0.07	0.35	NA	NA	0.39	neutral	0.61	disease	0.32	neutral	4	0.7	neutral	0.58	deleterious	-6	neutral	0.23	neutral	0.1	medium_impact	0.02	medium_impact	-1.19	low_impact	0.13	0.8	30.5	43.29	0.29	N	0.79	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3315	3315	G	C	MI.10773	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	9	3	M	I	atG/atC	-0.01	0	0	benign	0.07	neutral	0.49	neutral	2.92	neutral	0.94	neutral	0.86	neutral_impact	0	0.95	neutral	0.97	neutral	-0.02	2.41	deleterious	0.32	0.5	NA	NA	0.06	neutral	0.26	neutral	0.14	neutral	7	0.45	neutral	0.71	deleterious	-6	neutral	0.10	neutral	0.3	medium_impact	0.27	medium_impact	-1.19	low_impact	0.22	0.8	30.5	43.29	0.43	N	0.22	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3315	3315	G	T	MI.10774	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	9	3	M	I	atG/atT	-0.01	0	0	benign	0.07	neutral	0.49	neutral	2.92	neutral	0.94	neutral	0.86	neutral_impact	0	0.95	neutral	0.97	neutral	0.08	3.42	deleterious	0.32	0.5	NA	NA	0.06	neutral	0.26	neutral	0.14	neutral	7	0.45	neutral	0.71	deleterious	-6	neutral	0.10	neutral	0.3	medium_impact	0.27	medium_impact	-1.19	low_impact	0.22	0.8	30.5	43.29	0.44	N	0.22	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3316	3316	G	T	MI.10775	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	10	4	A	S	Gcc/Tcc	-3	0	0.04	benign	0.05	neutral	0.47	neutral	2.7	neutral	-1.81	neutral	-0.76	neutral_impact	0.08	0.85	neutral	0.73	neutral	1.58	13.74	neutral	0.26	0.45	NA	NA	0.08	neutral	0.39	neutral	0.11	neutral	8	0.49	neutral	0.71	deleterious	-6	neutral	0.15	neutral	0.45	medium_impact	0.25	medium_impact	-1.12	low_impact	0.39	0.8	22.01	29.35	0.38	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3316	3316	G	C	MI.10776	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	10	4	A	P	Gcc/Ccc	-3	0	0.04	benign	0.22	neutral	0.23	neutral	2.67	deleterious	-3.28	neutral	-1.62	low_impact	1.32	0.77	neutral	0.47	neutral	1.74	14.65	neutral	0.07	0.35	NA	NA	0.37	neutral	0.62	disease	0.3	neutral	4	0.73	neutral	0.51	deleterious	-6	neutral	0.32	neutral	-0.24	medium_impact	-0.02	medium_impact	-0.04	medium_impact	0.52	0.8	22.01	29.35	0.34	N	0.33	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3316	3316	G	A	MI.10777	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	10	4	A	T	Gcc/Acc	-3	0	0.04	benign	0	neutral	0.49	neutral	2.71	neutral	-1.4	neutral	0.05	neutral_impact	-0.76	0.94	neutral	0.9	neutral	1.04	10.90	neutral	0.3	0.45	NA	NA	0.05	neutral	0.24	neutral	0.12	neutral	8	0.51	neutral	0.75	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.27	medium_impact	-1.85	low_impact	0.43	0.8	22.01	29.35	0.44	N	0.05	polymorphism	1	0.01	rs2853516	.	.	.	.	.	.	.	.	G3316A	Diabetes / LHON / PEO	+	-	Unclear	18	N	N	N	neutral
chrM	3317	3317	C	T	MI.10778	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	11	4	A	V	gCc/gTc	-0.01	0	0	benign	0	neutral	0.51	neutral	2.86	neutral	0.47	neutral	2.65	neutral_impact	-0.9	0.94	neutral	0.96	neutral	0.93	10.27	neutral	0.24	0.45	NA	NA	0.03	neutral	0.19	neutral	0.09	neutral	8	0.49	neutral	0.76	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.29	medium_impact	-1.97	low_impact	0.64	0.8	22.01	29.35	0.36	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3317	3317	C	G	MI.10779	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	11	4	A	G	gCc/gGc	-0.01	0	0	benign	0.05	neutral	0.3	neutral	2.67	neutral	-2.82	neutral	-2.39	neutral_impact	0.52	0.84	neutral	0.69	neutral	1.86	15.37	deleterious	0.26	0.45	NA	NA	0.09	neutral	0.38	neutral	0.14	neutral	7	0.68	neutral	0.63	deleterious	-6	neutral	0.17	neutral	0.45	medium_impact	0.07	medium_impact	-0.73	medium_impact	0.62	0.8	22.01	29.35	0.46	N	0.31	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9032	9032	T	A	MI.1078	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	506	169	L	Q	cTa/cAa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	3.88	deleterious	-5.2	deleterious	-5.25	high_impact	4.37	0.36	damaging	0.48	neutral	4.17	23.80	deleterious	0.12	0.65	0.9	disease	0.84	disease	0.64	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.65	high_impact	0.69	0.9	50.88	8.57	0.61	P	0.98	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3317	3317	C	A	MI.10780	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	11	4	A	D	gCc/gAc	-0.01	0	0	benign	0.17	neutral	0.21	neutral	2.67	deleterious	-3.38	neutral	-1.9	low_impact	1.32	0.85	neutral	0.59	neutral	2.41	18.88	deleterious	0.04	0.35	NA	NA	0.3	neutral	0.61	disease	0.28	neutral	4	0.75	neutral	0.52	deleterious	-6	neutral	0.24	neutral	-0.1	medium_impact	-0.05	medium_impact	-0.04	medium_impact	0.28	0.8	22.01	29.35	0.4	N	0.30	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3319	3319	A	T	MI.10781	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	13	5	N	Y	Aac/Tac	-6.9	0	0	probably_damaging	1	neutral	0.4	neutral	2.7	neutral	-2.55	deleterious	-3.82	medium_impact	2.96	0.73	neutral	0.38	neutral	3.64	23.20	deleterious	0.14	0.4	NA	NA	0.61	disease	0.56	disease	0.64	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	0.18	medium_impact	1.4	medium_impact	0.32	0.8	60.06	9.95	0.31	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3319	3319	A	C	MI.10782	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	13	5	N	H	Aac/Cac	-6.9	0	0	probably_damaging	1	neutral	0.21	neutral	2.71	neutral	-1.82	deleterious	-3.17	medium_impact	2.83	0.75	neutral	0.36	neutral	2.94	22.00	deleterious	0.4	0.5	NA	NA	0.54	disease	0.56	disease	0.54	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	-0.05	medium_impact	1.28	medium_impact	0.19	0.8	60.06	9.95	0.37	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3319	3319	A	G	MI.10783	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	13	5	N	D	Aac/Gac	-6.9	0	0	probably_damaging	1	neutral	0.19	neutral	2.75	neutral	-0.74	deleterious	-3.93	medium_impact	2.71	0.73	neutral	0.47	neutral	3.73	23.30	deleterious	0.53	0.6	NA	NA	0.49	neutral	0.6	disease	0.62	disease	2	1	deleterious	0.1	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	-0.08	medium_impact	1.18	medium_impact	0.30	0.8	60.06	9.95	0.45	N	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3320	3320	A	G	MI.10784	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	14	5	N	S	aAc/aGc	3.67	0.99	0	probably_damaging	1	neutral	0.23	neutral	2.81	neutral	0	deleterious	-3.62	low_impact	1.02	0.84	neutral	0.57	neutral	3.53	23.10	deleterious	0.52	0.6	NA	NA	0.35	neutral	0.4	neutral	0.16	neutral	7	1	deleterious	0.12	neutral	-2	neutral	0.75	deleterious	-3.57	low_impact	-0.02	medium_impact	-0.3	medium_impact	0.23	0.8	60.06	9.95	0.55	P	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3320	3320	A	C	MI.10785	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	14	5	N	T	aAc/aCc	3.67	0.99	0	probably_damaging	1	neutral	0.29	neutral	2.76	neutral	-0.7	deleterious	-4.07	medium_impact	2.13	0.83	neutral	0.54	neutral	3.83	23.40	deleterious	0.31	0.45	NA	NA	0.5	neutral	0.59	disease	0.61	disease	2	1	deleterious	0.15	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.06	medium_impact	0.67	medium_impact	0.24	0.8	60.06	9.95	0.59	P	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3320	3320	A	T	MI.10786	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	14	5	N	I	aAc/aTc	3.67	0.99	0	probably_damaging	1	neutral	0.49	neutral	2.71	neutral	-2.09	deleterious	-5.52	medium_impact	2.19	0.78	neutral	0.52	neutral	4.40	24.10	deleterious	0.15	0.4	NA	NA	0.73	disease	0.58	disease	0.66	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	0.27	medium_impact	0.72	medium_impact	0.29	0.8	60.06	9.95	0.46	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3321	3321	C	A	MI.10787	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	15	5	N	K	aaC/aaA	5.27	0.99	0	probably_damaging	1	neutral	0.14	neutral	2.84	neutral	0.31	deleterious	-4.46	low_impact	1.52	0.7	neutral	0.34	neutral	4.41	24.10	deleterious	0.45	0.55	NA	NA	0.57	disease	0.44	neutral	0.44	neutral	1	1	deleterious	0.07	neutral	-2	neutral	0.79	deleterious	-3.57	low_impact	-0.17	medium_impact	0.14	medium_impact	0.40	0.8	60.06	9.95	0.59	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3321	3321	C	G	MI.10788	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	15	5	N	K	aaC/aaG	5.27	0.99	0	probably_damaging	1	neutral	0.14	neutral	2.84	neutral	0.31	deleterious	-4.46	low_impact	1.52	0.7	neutral	0.34	neutral	3.93	23.50	deleterious	0.45	0.55	NA	NA	0.57	disease	0.44	neutral	0.44	neutral	1	1	deleterious	0.07	neutral	-2	neutral	0.79	deleterious	-3.57	low_impact	-0.17	medium_impact	0.14	medium_impact	0.40	0.8	60.06	9.95	0.59	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3322	3322	C	G	MI.10789	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	16	6	L	V	Ctc/Gtc	-3.23	0	0	possibly_damaging	0.45	neutral	0.47	neutral	2.8	neutral	-0.2	neutral	-0.06	neutral_impact	0.78	0.9	neutral	0.95	neutral	1.08	11.12	neutral	0.34	0.5	NA	NA	0.21	neutral	0.23	neutral	0.19	neutral	6	0.49	neutral	0.51	deleterious	-3	neutral	0.32	neutral	-0.67	medium_impact	0.25	medium_impact	-0.51	medium_impact	0.56	0.8	22.96	18.02	0.44	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9032	9032	T	C	MI.1079	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	506	169	L	P	cTa/cCa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	3.87	deleterious	-5.6	deleterious	-6.19	high_impact	4.37	0.41	damaging	0.5	neutral	3.98	23.60	deleterious	0.14	0.65	0.92	disease	0.82	disease	0.74	disease	0.83	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.65	high_impact	0.63	0.9	50.88	8.57	0.62	P	1.00	disease_causing	0.84	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3322	3322	C	T	MI.10790	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	16	6	L	F	Ctc/Ttc	-3.23	0	0	possibly_damaging	0.9	neutral	0.42	neutral	2.7	neutral	-2.14	neutral	-1.47	low_impact	0.9	0.88	neutral	0.76	neutral	2.68	20.70	deleterious	0.25	0.45	NA	NA	0.24	neutral	0.25	neutral	0.19	neutral	6	0.89	neutral	0.26	neutral	-3	neutral	0.69	deleterious	-1.65	low_impact	0.2	medium_impact	-0.4	medium_impact	0.59	0.8	22.96	18.02	0.42	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3322	3322	C	A	MI.10791	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	16	6	L	I	Ctc/Atc	-3.23	0	0	benign	0.1	neutral	0.9	neutral	2.82	neutral	0.48	neutral	-0.33	neutral_impact	-0.12	0.91	neutral	0.95	neutral	2.24	17.75	deleterious	0.33	0.5	NA	NA	0.17	neutral	0.21	neutral	0.24	neutral	5	0.03	neutral	0.9	deleterious	-6	neutral	0.16	neutral	0.15	medium_impact	0.81	medium_impact	-1.29	low_impact	0.46	0.8	22.96	18.02	0.29	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3323	3323	T	C	MI.10792	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	17	6	L	P	cTc/cCc	-0.47	0	0	probably_damaging	0.96	neutral	0.06	neutral	2.68	deleterious	-3.73	neutral	3.51	neutral_impact	-0.08	0.67	neutral	0.66	neutral	1.67	14.25	neutral	0.03	0.35	NA	NA	0.07	neutral	0.47	neutral	0.23	neutral	6	0.99	deleterious	0.05	neutral	-2	neutral	0.70	deleterious	-2.05	low_impact	-0.4	medium_impact	-1.26	low_impact	0.11	0.8	22.96	18.02	0.47	N	0.96	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3323	3323	T	A	MI.10793	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	17	6	L	H	cTc/cAc	-0.47	0	0	probably_damaging	0.98	neutral	0.16	neutral	2.67	deleterious	-3.92	neutral	-1.25	medium_impact	2.27	0.76	neutral	0.52	neutral	4.06	23.70	deleterious	0.06	0.35	NA	NA	0.43	neutral	0.49	neutral	0.19	neutral	6	0.99	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-2.34	low_impact	-0.13	medium_impact	0.79	medium_impact	0.13	0.8	22.96	18.02	0.41	N	0.87	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3323	3323	T	G	MI.10794	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	17	6	L	R	cTc/cGc	-0.47	0	0	probably_damaging	0.94	neutral	0.08	neutral	2.69	deleterious	-3.31	neutral	-1.13	medium_impact	2.97	0.7	neutral	0.48	neutral	4.08	23.70	deleterious	0.03	0.35	NA	NA	0.71	disease	0.57	disease	0.73	disease	5	0.98	deleterious	0.07	neutral	1	deleterious	0.81	deleterious	-1.87	low_impact	-0.32	medium_impact	1.41	medium_impact	0.16	0.8	22.96	18.02	0.46	N	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3325	3325	C	G	MI.10795	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	19	7	L	V	Cta/Gta	-20	0	0	benign	0.21	neutral	0.53	neutral	2.27	neutral	-2.17	neutral	-2.14	medium_impact	2.25	0.86	neutral	0.3	neutral	3.36	22.90	deleterious	0.19	0.45	NA	NA	0.38	neutral	0.4	neutral	0.17	neutral	7	0.36	neutral	0.66	deleterious	-3	neutral	0.38	neutral	-0.21	medium_impact	0.3	medium_impact	0.78	medium_impact	0.56	0.8	54.4	8.9	0.25	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3325	3325	C	A	MI.10796	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	19	7	L	M	Cta/Ata	-20	0	0	benign	0.33	neutral	0.29	neutral	2.15	deleterious	-3.64	neutral	-1.33	medium_impact	3	0.9	neutral	0.71	neutral	3.66	23.20	deleterious	0.13	0.4	NA	NA	0.34	neutral	0.52	disease	0.31	neutral	4	0.65	neutral	0.48	deleterious	-3	neutral	0.38	neutral	-0.46	medium_impact	0.06	medium_impact	1.43	medium_impact	0.43	0.8	54.4	8.9	0.42	N	0.62	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3326	3326	T	G	MI.10797	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	20	7	L	R	cTa/cGa	-1.16	0	0	probably_damaging	0.91	neutral	0.27	neutral	2.09	deleterious	-5.88	deleterious	-4.65	high_impact	4.2	0.79	neutral	0.1	damaging	4.18	23.80	deleterious	0.02	0.35	NA	NA	0.81	disease	0.73	disease	0.75	disease	5	0.93	neutral	0.18	neutral	2	deleterious	0.85	deleterious	-1.69	low_impact	0.03	medium_impact	2.48	high_impact	0.17	0.8	54.4	8.9	0.37	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3326	3326	T	A	MI.10798	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	20	7	L	Q	cTa/cAa	-1.16	0	0	probably_damaging	0.91	neutral	0.32	neutral	2.09	deleterious	-5.84	deleterious	-4.57	high_impact	3.64	0.77	neutral	0.14	damaging	4.05	23.70	deleterious	0.02	0.35	NA	NA	0.64	disease	0.62	disease	0.68	disease	4	0.92	neutral	0.21	neutral	2	deleterious	0.76	deleterious	-1.69	low_impact	0.09	medium_impact	1.99	medium_impact	0.34	0.8	54.4	8.9	0.33	N	0.95	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3326	3326	T	C	MI.10799	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	20	7	L	P	cTa/cCa	-1.16	0	0	probably_damaging	0.95	neutral	0.2	neutral	2.09	deleterious	-6.4	deleterious	-4.8	high_impact	4.2	0.78	neutral	0.11	damaging	3.89	23.50	deleterious	0.02	0.35	NA	NA	0.71	disease	0.74	disease	0.74	disease	5	0.97	neutral	0.13	neutral	2	deleterious	0.84	deleterious	-1.95	low_impact	-0.06	medium_impact	2.48	high_impact	0.28	0.8	54.4	8.9	0.38	N	0.93	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8576	8576	T	C	MI.108	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	50	17	L	P	cTa/cCa	-0.57	0	0	probably_damaging	1	deleterious	0.04	neutral	4.4	deleterious	-4.86	deleterious	-4.75	medium_impact	2.22	0.76	neutral	0.32	neutral	3.69	23.30	deleterious	0.17	0.65	0.91	disease	0.9	disease	0.67	disease	0.83	disease	7	1	deleterious	0.02	neutral	5	deleterious	0.90	deleterious	-3.6	low_impact	-0.49	medium_impact	0.81	medium_impact	0.63	0.9	28.76	21.22	0.25	N	0.88	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9034	9034	C	T	MI.1080	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	508	170	L	F	Ctc/Ttc	-8.66	0	0	probably_damaging	1	deleterious	0.01	neutral	3.87	deleterious	-3.2	deleterious	-3.52	high_impact	4.1	0.6	neutral	0.15	damaging	4.05	23.70	deleterious	0.36	0.65	0.82	disease	0.74	disease	0.64	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	2.42	high_impact	0.59	0.9	48.67	8.89	0.28	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3328	3328	C	G	MI.10800	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	22	8	L	V	Ctc/Gtc	-0.93	0	0	benign	0.04	neutral	0.55	neutral	2.73	neutral	-0.86	neutral	-0.41	low_impact	1.74	0.91	neutral	0.86	neutral	1.90	15.62	deleterious	0.27	0.45	NA	NA	0.27	neutral	0.23	neutral	0.18	neutral	6	0.4	neutral	0.76	deleterious	-6	neutral	0.16	neutral	0.55	medium_impact	0.32	medium_impact	0.33	medium_impact	0.44	0.8	19.18	28.55	0.33	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3328	3328	C	T	MI.10801	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	22	8	L	F	Ctc/Ttc	-0.93	0	0	possibly_damaging	0.84	neutral	0.7	neutral	2.63	neutral	-1.98	neutral	-1.7	low_impact	1.66	0.87	neutral	0.79	neutral	2.45	19.17	deleterious	0.27	0.45	NA	NA	0.3	neutral	0.25	neutral	0.18	neutral	6	0.81	neutral	0.43	neutral	-3	neutral	0.68	deleterious	-1.43	low_impact	0.48	medium_impact	0.26	medium_impact	0.38	0.8	19.18	28.55	0.33	N	0.31	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3328	3328	C	A	MI.10802	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	22	8	L	I	Ctc/Atc	-0.93	0	0	benign	0.33	neutral	0.84	neutral	2.73	neutral	-0.95	neutral	-0.49	low_impact	1.43	0.82	neutral	0.73	neutral	2.44	19.07	deleterious	0.27	0.45	NA	NA	0.24	neutral	0.16	neutral	0.18	neutral	6	0.22	neutral	0.76	deleterious	-6	neutral	0.31	neutral	-0.46	medium_impact	0.68	medium_impact	0.06	medium_impact	0.31	0.8	19.18	28.55	0.31	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3329	3329	T	G	MI.10803	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	23	8	L	R	cTc/cGc	-3.92	0	0	probably_damaging	0.91	neutral	0.21	neutral	2.62	deleterious	-3.74	neutral	-2.12	high_impact	3.75	0.77	neutral	0.48	neutral	2.86	21.70	deleterious	0.03	0.35	NA	NA	0.76	disease	0.61	disease	0.74	disease	5	0.94	neutral	0.15	neutral	2	deleterious	0.80	deleterious	-1.69	low_impact	-0.05	medium_impact	2.09	high_impact	0.16	0.8	19.18	28.55	0.4	N	0.62	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3329	3329	T	A	MI.10804	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	23	8	L	H	cTc/cAc	-3.92	0	0	probably_damaging	0.97	neutral	0.56	neutral	2.6	deleterious	-4.31	deleterious	-2.75	medium_impact	2.87	0.77	neutral	0.56	neutral	2.94	22.00	deleterious	0.06	0.35	NA	NA	0.54	disease	0.48	neutral	0.5	neutral	0	0.96	neutral	0.3	neutral	1	deleterious	0.74	deleterious	-2.17	low_impact	0.33	medium_impact	1.32	medium_impact	0.17	0.8	19.18	28.55	0.27	N	0.63	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3329	3329	T	C	MI.10805	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	23	8	L	P	cTc/cCc	-3.92	0	0	probably_damaging	0.93	neutral	0.18	neutral	2.6	deleterious	-4.04	neutral	-2.26	medium_impact	3.41	0.81	neutral	0.43	neutral	3.65	23.20	deleterious	0.04	0.35	NA	NA	0.74	disease	0.62	disease	0.73	disease	5	0.96	neutral	0.13	neutral	1	deleterious	0.78	deleterious	-1.81	low_impact	-0.09	medium_impact	1.79	medium_impact	0.22	0.8	19.18	28.55	0.34	N	0.87	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3331	3331	C	G	MI.10806	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	25	9	L	V	Ctc/Gtc	-4.38	0	0	benign	0.03	neutral	0.44	neutral	2.58	neutral	-1.35	neutral	-0.59	low_impact	1.2	0.94	neutral	0.94	neutral	2.09	16.81	deleterious	0.33	0.5	NA	NA	0.51	disease	0.27	neutral	0.47	neutral	1	0.53	neutral	0.71	deleterious	-6	neutral	0.19	neutral	0.67	medium_impact	0.22	medium_impact	-0.14	medium_impact	0.49	0.8	23.58	29.46	0.36	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3331	3331	C	T	MI.10807	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	25	9	L	F	Ctc/Ttc	-4.38	0	0	possibly_damaging	0.73	neutral	0.38	neutral	2.51	neutral	-2.2	neutral	1.16	low_impact	1.46	0.88	neutral	0.93	neutral	2.36	18.58	deleterious	0.3	0.45	NA	NA	0.43	neutral	0.28	neutral	0.23	neutral	5	0.75	neutral	0.33	neutral	-3	neutral	0.65	deleterious	-1.16	low_impact	0.16	medium_impact	0.09	medium_impact	0.37	0.8	23.58	29.46	0.43	N	0.32	polymorphism	1	0.02	rs878932147	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3331	3331	C	A	MI.10808	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	25	9	L	I	Ctc/Atc	-4.38	0	0	benign	0.04	neutral	1	neutral	2.65	neutral	-0.84	neutral	-0.36	low_impact	1.02	0.91	neutral	0.81	neutral	3.79	23.40	deleterious	0.29	0.45	NA	NA	0.51	disease	0.23	neutral	0.44	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.19	neutral	0.55	medium_impact	1.96	high_impact	-0.3	medium_impact	0.31	0.8	23.58	29.46	0.26	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3332	3332	T	A	MI.10809	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	26	9	L	H	cTc/cAc	-0.24	0	0	probably_damaging	0.96	neutral	0.15	neutral	2.43	deleterious	-4.61	neutral	-0.74	medium_impact	2.94	0.72	neutral	0.52	neutral	3.86	23.50	deleterious	0.07	0.35	NA	NA	0.72	disease	0.59	disease	0.72	disease	4	0.98	neutral	0.1	neutral	1	deleterious	0.77	deleterious	-2.05	low_impact	-0.15	medium_impact	1.38	medium_impact	0.14	0.8	23.58	29.46	0.42	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9034	9034	C	G	MI.1081	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	508	170	L	V	Ctc/Gtc	-8.66	0	0	probably_damaging	0.99	neutral	0.08	neutral	4.04	neutral	-1.47	deleterious	-2.64	medium_impact	2.44	0.58	damaging	0.17	damaging	3.51	23.10	deleterious	0.32	0.65	0.42	neutral	0.59	disease	0.62	disease	0.57	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.74	deleterious	-2.65	low_impact	-0.31	medium_impact	0.99	medium_impact	0.63	0.9	48.67	8.89	0.29	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3332	3332	T	G	MI.10810	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	26	9	L	R	cTc/cGc	-0.24	0	0	possibly_damaging	0.88	neutral	0.07	neutral	2.44	deleterious	-3.99	neutral	-2.33	medium_impact	3.49	0.68	neutral	0.46	neutral	3.94	23.50	deleterious	0.04	0.35	NA	NA	0.89	disease	0.64	disease	0.79	disease	6	0.97	neutral	0.1	neutral	0	NA	0.82	deleterious	-1.56	low_impact	-0.35	medium_impact	1.86	medium_impact	0.19	0.8	23.58	29.46	0.46	N	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3332	3332	T	C	MI.10811	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	26	9	L	P	cTc/cCc	-0.24	0	0	probably_damaging	0.91	neutral	0.08	neutral	2.43	deleterious	-4.62	deleterious	-2.64	medium_impact	2.25	0.62	neutral	0.33	neutral	3.67	23.30	deleterious	0.04	0.35	NA	NA	0.86	disease	0.65	disease	0.79	disease	6	0.97	neutral	0.09	neutral	1	deleterious	0.80	deleterious	-1.69	low_impact	-0.32	medium_impact	0.78	medium_impact	0.15	0.8	23.58	29.46	0.32	N	0.92	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3334	3334	A	G	MI.10812	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	28	10	I	V	Att/Gtt	-6.67	0	0	benign	0.01	neutral	0.51	neutral	2.55	neutral	-1.3	neutral	-0.75	medium_impact	2.12	0.89	neutral	0.91	neutral	-0.16	1.32	neutral	0.41	0.5	NA	NA	0.32	neutral	0.34	neutral	0.16	neutral	7	0.48	neutral	0.75	deleterious	-3	neutral	0.14	neutral	1.12	medium_impact	0.29	medium_impact	0.66	medium_impact	0.25	0.8	20.75	32.42	0.38	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3334	3334	A	T	MI.10813	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	28	10	I	F	Att/Ttt	-6.67	0	0	possibly_damaging	0.69	neutral	0.55	neutral	2.39	deleterious	-3.31	deleterious	-2.99	low_impact	1.93	0.71	neutral	0.47	neutral	1.75	14.69	neutral	0.15	0.4	NA	NA	0.72	disease	0.37	neutral	0.51	disease	0	0.65	neutral	0.43	neutral	-3	neutral	0.63	deleterious	-1.08	low_impact	0.32	medium_impact	0.5	medium_impact	0.31	0.8	20.75	32.42	0.32	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3334	3334	A	C	MI.10814	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	28	10	I	L	Att/Ctt	-6.67	0	0	benign	0.09	neutral	1	neutral	2.74	neutral	-0.27	neutral	-1.26	low_impact	1.46	0.89	neutral	0.89	neutral	0.53	7.64	deleterious	0.2	0.45	NA	NA	0.58	disease	0.28	neutral	0.45	neutral	1	0.09	neutral	0.96	deleterious	-6	neutral	0.21	neutral	0.19	medium_impact	1.96	high_impact	0.09	medium_impact	0.35	0.8	20.75	32.42	0.26	N	0.11	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3335	3335	T	G	MI.10815	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	29	10	I	S	aTt/aGt	0.45	0	0.01	benign	0.3	neutral	0.35	neutral	2.36	deleterious	-4.36	deleterious	-4.65	medium_impact	2.34	0.86	neutral	0.47	neutral	2.12	17.01	deleterious	0.06	0.35	NA	NA	0.8	disease	0.55	disease	0.69	disease	4	0.58	neutral	0.53	deleterious	-3	neutral	0.38	neutral	-0.41	medium_impact	0.12	medium_impact	0.86	medium_impact	0.23	0.8	20.75	32.42	0.33	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3335	3335	T	C	MI.10816	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	29	10	I	T	aTt/aCt	0.45	0	0.01	benign	0.01	neutral	0.22	neutral	2.38	deleterious	-3.69	deleterious	-3.87	medium_impact	2.58	0.87	neutral	0.91	neutral	1.18	11.67	neutral	0.14	0.4	NA	NA	0.64	disease	0.39	neutral	0.49	neutral	0	0.77	neutral	0.61	deleterious	-3	neutral	0.19	neutral	1.12	medium_impact	-0.03	medium_impact	1.07	medium_impact	0.20	0.8	20.75	32.42	0.46	N	0.98	polymorphism	1	0.11	rs879173824	.	.	.	.	.	.	.	.	T3335C	LHON	+	-	Reported	1	N	P	N,P	damaging
chrM	3335	3335	T	A	MI.10817	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	29	10	I	N	aTt/aAt	0.45	0	0.01	possibly_damaging	0.54	neutral	0.38	neutral	2.35	deleterious	-5.41	deleterious	-5.51	high_impact	4.07	0.76	neutral	0.4	neutral	2.28	18.02	deleterious	0.1	0.4	NA	NA	0.78	disease	0.59	disease	0.69	disease	4	0.62	neutral	0.42	neutral	1	deleterious	0.57	deleterious	-0.82	medium_impact	0.16	medium_impact	2.37	high_impact	0.27	0.8	20.75	32.42	0.39	N	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3336	3336	T	G	MI.10818	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	30	10	I	M	atT/atG	1.83	0.01	0.03	possibly_damaging	0.76	neutral	0.2	neutral	2.49	neutral	-1.79	neutral	-1.87	low_impact	1.57	0.84	neutral	0.8	neutral	0.41	6.69	deleterious	0.28	0.45	NA	NA	0.51	disease	0.31	neutral	0.43	neutral	1	0.86	neutral	0.22	neutral	-3	neutral	0.58	deleterious	-1.22	low_impact	-0.06	medium_impact	0.18	medium_impact	0.39	0.8	20.75	32.42	0.45	N	0.43	polymorphism	1	0.04	rs28416101	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3336	3336	T	A	MI.10819	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	30	10	I	M	atT/atA	1.83	0.01	0.03	possibly_damaging	0.76	neutral	0.2	neutral	2.49	neutral	-1.79	neutral	-1.87	low_impact	1.57	0.84	neutral	0.8	neutral	0.75	9.15	deleterious	0.28	0.45	NA	NA	0.51	disease	0.31	neutral	0.43	neutral	1	0.86	neutral	0.22	neutral	-3	neutral	0.58	deleterious	-1.22	low_impact	-0.06	medium_impact	0.18	medium_impact	0.39	0.8	20.75	32.42	0.42	N	0.43	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9034	9034	C	A	MI.1082	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	508	170	L	I	Ctc/Atc	-8.66	0	0	probably_damaging	0.99	neutral	0.27	neutral	4.06	neutral	-1.37	neutral	-1.76	medium_impact	2.56	0.63	neutral	0.17	damaging	4.18	23.80	deleterious	0.3	0.65	0.5	disease	0.64	disease	0.41	neutral	0.46	neutral	1	0.99	deleterious	0.14	neutral	1	deleterious	0.77	deleterious	-2.65	low_impact	0.05	medium_impact	1.1	medium_impact	0.75	0.9	48.67	8.89	0.32	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3337	3337	G	C	MI.10820	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	31	11	V	L	Gta/Cta	-5.07	0	0	benign	0	neutral	1	neutral	2.79	neutral	-0.08	neutral	-1.26	neutral_impact	-0.39	0.91	neutral	0.93	neutral	0.04	2.99	deleterious	0.22	0.45	NA	NA	0.65	disease	0.27	neutral	0.45	neutral	1	0	neutral	1	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	1.96	high_impact	-1.53	low_impact	0.18	0.8	22.01	23.44	0.25	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3337	3337	G	A	MI.10821	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	31	11	V	M	Gta/Ata	-5.07	0	0	benign	0.03	neutral	0.31	neutral	2.51	neutral	-2.9	neutral	-1.84	low_impact	0.96	0.91	neutral	0.65	neutral	1.44	13.01	neutral	0.14	0.4	NA	NA	0.71	disease	0.44	neutral	0.52	disease	0	0.67	neutral	0.64	deleterious	-6	neutral	0.16	neutral	0.67	medium_impact	0.08	medium_impact	-0.35	medium_impact	0.46	0.8	22.01	23.44	0.34	N	0.05	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	G3337A	Cardiomyopathy	+	-	Possibly synergistic	1	.	N	N	damaging
chrM	3337	3337	G	T	MI.10822	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	31	11	V	L	Gta/Tta	-5.07	0	0	benign	0	neutral	1	neutral	2.79	neutral	-0.08	neutral	-1.26	neutral_impact	-0.39	0.91	neutral	0.93	neutral	0.19	4.62	deleterious	0.22	0.45	NA	NA	0.65	disease	0.27	neutral	0.45	neutral	1	0	neutral	1	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	1.96	high_impact	-1.53	low_impact	0.18	0.8	22.01	23.44	0.25	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3338	3338	T	G	MI.10823	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	32	11	V	G	gTa/gGa	-3	0	0.01	benign	0.21	neutral	0.29	neutral	2.47	deleterious	-4.46	deleterious	-5.73	low_impact	1.66	0.74	neutral	0.4	neutral	1.61	13.91	neutral	0.06	0.35	NA	NA	0.8	disease	0.56	disease	0.73	disease	5	0.65	neutral	0.54	deleterious	-6	neutral	0.30	neutral	-0.21	medium_impact	0.06	medium_impact	0.26	medium_impact	0.32	0.8	22.01	23.44	0.35	N	0.78	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3338	3338	T	C	MI.10824	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	32	11	V	A	gTa/gCa	-3	0	0.01	benign	0.01	neutral	0.5	neutral	2.56	neutral	-1.87	deleterious	-3.16	neutral_impact	0.08	0.95	neutral	0.93	neutral	0.14	4.00	deleterious	0.12	0.4	NA	NA	0.51	disease	0.36	neutral	0.45	neutral	1	0.49	neutral	0.75	deleterious	-6	neutral	0.16	neutral	1.12	medium_impact	0.28	medium_impact	-1.12	low_impact	0.08	0.8	22.01	23.44	0.29	N	0.49	polymorphism	1	0.10	rs201969351	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3338	3338	T	A	MI.10825	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	32	11	V	E	gTa/gAa	-3	0	0.01	benign	0.28	neutral	0.23	neutral	2.48	deleterious	-4.25	deleterious	-4.94	medium_impact	2.86	0.8	neutral	0.32	neutral	2.47	19.26	deleterious	0.03	0.35	NA	NA	0.91	disease	0.67	disease	0.8	disease	6	0.72	neutral	0.48	deleterious	-3	neutral	0.41	neutral	-0.37	medium_impact	-0.02	medium_impact	1.31	medium_impact	0.15	0.8	22.01	23.44	0.32	N	0.88	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3340	3340	C	A	MI.10826	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	34	12	P	T	Ccc/Acc	-12.42	0	0	possibly_damaging	0.46	neutral	0.3	neutral	2.75	neutral	-1.24	deleterious	-6.11	medium_impact	3.21	0.74	neutral	0.39	neutral	1.55	13.55	neutral	0.21	0.45	NA	NA	0.74	disease	0.43	neutral	0.51	disease	0	0.66	neutral	0.42	neutral	0	NA	0.51	deleterious	-0.69	medium_impact	0.07	medium_impact	1.62	medium_impact	0.44	0.8	21.07	20.74	0.42	N	0.74	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3340	3340	C	T	MI.10827	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	34	12	P	S	Ccc/Tcc	-12.42	0	0	benign	0.04	neutral	0.26	neutral	2.75	neutral	-1.22	deleterious	-6.07	low_impact	1.26	0.76	neutral	0.63	neutral	1.66	14.17	neutral	0.19	0.45	NA	NA	0.73	disease	0.31	neutral	0.5	disease	0	0.72	neutral	0.61	deleterious	-6	neutral	0.23	neutral	0.55	medium_impact	0.02	medium_impact	-0.09	medium_impact	0.24	0.8	21.07	20.74	0.41	N	0.28	polymorphism	1	0.12	.	.	.	.	.	.	.	CPD	2.97	C3340T	Encephaloneuromyopathy	+	-	Reported	1	.	P	P	damaging
chrM	3340	3340	C	G	MI.10828	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	34	12	P	A	Ccc/Gcc	-12.42	0	0	benign	0.23	neutral	0.31	neutral	2.79	neutral	-0.15	deleterious	-6.12	medium_impact	2.6	0.8	neutral	0.44	neutral	0.93	10.23	neutral	0.2	0.45	NA	NA	0.66	disease	0.4	neutral	0.51	disease	0	0.63	neutral	0.54	deleterious	-3	neutral	0.37	neutral	-0.26	medium_impact	0.08	medium_impact	1.08	medium_impact	0.52	0.8	21.07	20.74	0.37	N	0.60	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3341	3341	C	G	MI.10829	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	35	12	P	R	cCc/cGc	1.14	0.07	0	possibly_damaging	0.82	neutral	0.2	neutral	2.71	neutral	-2.61	deleterious	-7.03	high_impact	3.67	0.76	neutral	0.39	neutral	1.54	13.53	neutral	0.08	0.35	NA	NA	0.93	disease	0.66	disease	0.79	disease	6	0.89	neutral	0.19	neutral	1	deleterious	0.80	deleterious	-1.37	low_impact	-0.06	medium_impact	2.02	high_impact	0.36	0.8	21.07	20.74	0.45	N	0.94	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9035	9035	T	A	MI.1083	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	509	170	L	H	cTc/cAc	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	3.81	deleterious	-5.89	deleterious	-6.17	high_impact	4.45	0.47	damaging	0.14	damaging	4.32	24.00	deleterious	0.16	0.65	0.92	disease	0.82	disease	0.71	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.72	high_impact	0.52	0.9	48.67	8.89	0.4	N	0.97	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3341	3341	C	T	MI.10830	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	35	12	P	L	cCc/cTc	1.14	0.07	0	possibly_damaging	0.59	neutral	1	neutral	2.78	neutral	-0.34	deleterious	-7.56	medium_impact	2.25	0.75	neutral	0.39	neutral	2.25	17.86	deleterious	0.13	0.4	NA	NA	0.89	disease	0.43	neutral	0.67	disease	3	0.59	neutral	0.71	deleterious	0	NA	0.56	deleterious	-0.9	medium_impact	1.96	high_impact	0.78	medium_impact	0.50	0.8	21.07	20.74	0.28	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3341	3341	C	A	MI.10831	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	35	12	P	H	cCc/cAc	1.14	0.07	0	probably_damaging	0.92	neutral	0.31	neutral	2.69	deleterious	-3.28	deleterious	-6.85	high_impact	4.02	0.78	neutral	0.31	neutral	3.56	23.10	deleterious	0.11	0.4	NA	NA	0.87	disease	0.64	disease	0.73	disease	5	0.94	neutral	0.2	neutral	2	deleterious	0.81	deleterious	-1.75	low_impact	0.08	medium_impact	2.32	high_impact	0.26	0.8	21.07	20.74	0.4	N	0.88	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3343	3343	A	T	MI.10832	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	37	13	I	F	Att/Ttt	-11.96	0	0	benign	0.17	neutral	0.21	neutral	2.47	deleterious	-3.47	deleterious	-3.54	medium_impact	3	0.75	neutral	0.34	neutral	1.86	15.35	deleterious	0.16	0.45	NA	NA	0.81	disease	0.49	neutral	0.69	disease	4	0.75	neutral	0.52	deleterious	-3	neutral	0.30	neutral	-0.1	medium_impact	-0.05	medium_impact	1.43	medium_impact	0.28	0.8	22.96	30.5	0.39	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3343	3343	A	C	MI.10833	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	37	13	I	L	Att/Ctt	-11.96	0	0	benign	0.01	neutral	1	neutral	2.62	neutral	-1.05	neutral	-1.76	medium_impact	2.04	0.76	neutral	0.54	neutral	1.67	14.23	neutral	0.19	0.45	NA	NA	0.65	disease	0.29	neutral	0.47	neutral	1	0.01	neutral	1	deleterious	-3	neutral	0.18	neutral	1.12	medium_impact	1.96	high_impact	0.59	medium_impact	0.32	0.8	22.96	30.5	0.24	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3343	3343	A	G	MI.10834	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	37	13	I	V	Att/Gtt	-11.96	0	0	benign	0	neutral	0.3	neutral	3	neutral	0.71	neutral	-0.18	low_impact	0.82	0.94	neutral	0.96	neutral	-1.43	0.00	neutral	0.32	0.5	NA	NA	0.08	neutral	0.23	neutral	0.23	neutral	5	0.7	neutral	0.65	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.07	medium_impact	-0.47	medium_impact	0.28	0.8	22.96	30.5	0.54	P	0.55	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3344	3344	T	C	MI.10835	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	38	13	I	T	aTt/aCt	1.6	0.87	0	benign	0	neutral	0.13	neutral	2.48	deleterious	-3.02	deleterious	-3.7	medium_impact	2.59	0.92	neutral	0.62	neutral	0.07	3.27	deleterious	0.15	0.4	NA	NA	0.6	disease	0.55	disease	0.61	disease	2	0.87	neutral	0.57	deleterious	-3	neutral	0.17	neutral	2.07	high_impact	-0.19	medium_impact	1.07	medium_impact	0.24	0.8	22.96	30.5	0.42	N	0.58	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3344	3344	T	G	MI.10836	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	38	13	I	S	aTt/aGt	1.6	0.87	0	benign	0.05	neutral	0.21	neutral	2.47	deleterious	-3.68	deleterious	-4.94	medium_impact	2.67	0.75	neutral	0.37	neutral	2.14	17.14	deleterious	0.09	0.35	NA	NA	0.81	disease	0.56	disease	0.73	disease	5	0.77	neutral	0.58	deleterious	-3	neutral	0.22	neutral	0.45	medium_impact	-0.05	medium_impact	1.14	medium_impact	0.20	0.8	22.96	30.5	0.4	N	0.88	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3344	3344	T	A	MI.10837	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	38	13	I	N	aTt/aAt	1.6	0.87	0	benign	0.13	deleterious	0.04	neutral	2.45	deleterious	-4.71	deleterious	-5.84	high_impact	3.75	0.76	neutral	0.36	neutral	2.22	17.64	deleterious	0.16	0.45	NA	NA	0.83	disease	0.57	disease	0.75	disease	5	0.96	neutral	0.46	neutral	2	deleterious	0.28	neutral	0.02	medium_impact	-0.5	medium_impact	2.09	high_impact	0.20	0.8	22.96	30.5	0.46	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3345	3345	T	G	MI.10838	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	39	13	I	M	atT/atG	4.58	0.95	0	benign	0.38	neutral	0.31	neutral	2.48	deleterious	-3.21	neutral	-2.3	medium_impact	2.94	0.75	neutral	0.34	neutral	1.27	12.13	neutral	0.34	0.5	NA	NA	0.67	disease	0.56	disease	0.69	disease	4	0.63	neutral	0.47	neutral	-3	neutral	0.33	neutral	-0.55	medium_impact	0.08	medium_impact	1.38	medium_impact	0.38	0.8	22.96	30.5	0.53	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3345	3345	T	A	MI.10839	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	39	13	I	M	atT/atA	4.58	0.95	0	benign	0.38	neutral	0.31	neutral	2.48	deleterious	-3.21	neutral	-2.3	medium_impact	2.94	0.75	neutral	0.34	neutral	1.62	13.98	neutral	0.34	0.5	NA	NA	0.67	disease	0.56	disease	0.69	disease	4	0.63	neutral	0.47	neutral	-3	neutral	0.33	neutral	-0.55	medium_impact	0.08	medium_impact	1.38	medium_impact	0.38	0.8	22.96	30.5	0.54	P	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9035	9035	T	G	MI.1084	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	509	170	L	R	cTc/cGc	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	3.81	deleterious	-5.31	deleterious	-5.29	high_impact	4.45	0.37	damaging	0.13	damaging	4.25	23.90	deleterious	0.16	0.65	0.89	disease	0.88	disease	0.74	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.72	high_impact	0.51	0.9	48.67	8.89	0.56	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3346	3346	C	G	MI.10840	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	40	14	L	V	Cta/Gta	-8.28	0	0	benign	0.3	neutral	0.61	neutral	2.61	neutral	-1.51	deleterious	-2.57	medium_impact	3.19	0.68	neutral	0.37	neutral	3.17	22.70	deleterious	0.32	0.5	NA	NA	0.58	disease	0.6	disease	0.65	disease	3	0.3	neutral	0.66	deleterious	-3	neutral	0.40	neutral	-0.41	medium_impact	0.38	medium_impact	1.6	medium_impact	0.47	0.8	20.75	16.16	0.28	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3346	3346	C	A	MI.10841	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	40	14	L	M	Cta/Ata	-8.28	0	0	benign	0.25	neutral	0.21	neutral	2.49	neutral	-2.23	neutral	-1.68	medium_impact	2.81	0.82	neutral	0.61	neutral	3.44	23.00	deleterious	0.25	0.45	NA	NA	0.48	neutral	0.5	neutral	0.32	neutral	4	0.75	neutral	0.48	deleterious	-3	neutral	0.27	neutral	-0.3	medium_impact	-0.05	medium_impact	1.27	medium_impact	0.31	0.8	20.75	16.16	0.37	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3347	3347	T	A	MI.10842	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	41	14	L	Q	cTa/cAa	-1.16	0	0	probably_damaging	0.94	neutral	0.08	neutral	2.42	deleterious	-4.62	deleterious	-5.22	high_impact	4.29	0.7	neutral	0.34	neutral	3.75	23.30	deleterious	0.07	0.35	NA	NA	0.76	disease	0.62	disease	0.68	disease	4	0.98	deleterious	0.07	neutral	2	deleterious	0.81	deleterious	-1.87	low_impact	-0.32	medium_impact	2.56	high_impact	0.20	0.8	20.75	16.16	0.46	N	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3347	3347	T	C	MI.10843	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	41	14	L	P	cTa/cCa	-1.16	0	0	probably_damaging	0.97	neutral	0.1	neutral	2.4	deleterious	-4.79	deleterious	-6.08	high_impact	4.64	0.63	neutral	0.29	neutral	3.64	23.20	deleterious	0.05	0.35	NA	NA	0.79	disease	0.72	disease	0.73	disease	5	0.99	deleterious	0.07	neutral	2	deleterious	0.88	deleterious	-2.17	low_impact	-0.26	medium_impact	2.86	high_impact	0.20	0.8	20.75	16.16	0.47	N	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3347	3347	T	G	MI.10844	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	41	14	L	R	cTa/cGa	-1.16	0	0	probably_damaging	0.94	neutral	0.05	neutral	2.42	deleterious	-4.47	deleterious	-5.24	high_impact	4.64	0.7	neutral	0.25	damaging	3.87	23.50	deleterious	0.04	0.35	NA	NA	0.89	disease	0.73	disease	0.79	disease	6	0.99	deleterious	0.06	neutral	2	deleterious	0.88	deleterious	-1.87	low_impact	-0.44	medium_impact	2.86	high_impact	0.13	0.8	20.75	16.16	0.54	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3349	3349	A	G	MI.10845	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	43	15	I	V	Atc/Gtc	-6.21	0	0	benign	0.01	neutral	0.59	neutral	2.81	neutral	0.07	neutral	-0.74	neutral_impact	0.62	0.95	neutral	0.97	neutral	1.62	13.99	neutral	0.38	0.5	NA	NA	0.18	neutral	0.22	neutral	0.21	neutral	6	0.4	neutral	0.79	deleterious	-6	neutral	0.12	neutral	1.12	medium_impact	0.36	medium_impact	-0.65	medium_impact	0.30	0.8	27.36	46.43	0.39	N	0.60	polymorphism	1	0.02	rs879193727	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3349	3349	A	T	MI.10846	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	43	15	I	F	Atc/Ttc	-6.21	0	0	possibly_damaging	0.44	neutral	0.36	neutral	2.67	neutral	-1.46	neutral	-2.25	medium_impact	2.57	0.86	neutral	0.5	neutral	3.56	23.10	deleterious	0.15	0.4	NA	NA	0.65	disease	0.52	disease	0.6	disease	2	0.59	neutral	0.46	neutral	0	NA	0.41	neutral	-0.65	medium_impact	0.14	medium_impact	1.06	medium_impact	0.25	0.8	27.36	46.43	0.33	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3349	3349	A	C	MI.10847	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	43	15	I	L	Atc/Ctc	-6.21	0	0	benign	0.01	neutral	1	neutral	2.86	neutral	0.42	neutral	0.81	neutral_impact	-0.58	0.84	neutral	0.93	neutral	0.76	9.21	deleterious	0.24	0.45	NA	NA	0.16	neutral	0.19	neutral	0.23	neutral	5	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	1.96	high_impact	-1.7	low_impact	0.20	0.8	27.36	46.43	0.32	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3350	3350	T	A	MI.10848	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	44	15	I	N	aTc/aAc	-0.7	0	0	possibly_damaging	0.52	deleterious	0.03	neutral	2.66	deleterious	-3.59	deleterious	-4.84	medium_impact	2.92	0.72	neutral	0.41	neutral	4.33	24.00	deleterious	0.11	0.4	NA	NA	0.72	disease	0.51	disease	0.59	disease	2	0.97	neutral	0.26	neutral	4	deleterious	0.57	deleterious	-0.78	medium_impact	-0.57	medium_impact	1.36	medium_impact	0.19	0.8	27.36	46.43	0.4	N	0.83	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3350	3350	T	C	MI.10849	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	44	15	I	T	aTc/aCc	-0.7	0	0	benign	0.01	deleterious	0.04	neutral	2.72	neutral	-1.45	deleterious	-3	medium_impact	2.23	0.8	neutral	0.59	neutral	3.22	22.70	deleterious	0.18	0.45	NA	NA	0.42	neutral	0.49	neutral	0.2	neutral	6	0.96	neutral	0.52	deleterious	1	deleterious	0.15	neutral	1.12	medium_impact	-0.5	medium_impact	0.76	medium_impact	0.19	0.8	27.36	46.43	0.43	N	0.55	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9035	9035	T	C	MI.1085	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	509	170	L	P	cTc/cCc	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	3.81	deleterious	-5.85	deleterious	-6.22	high_impact	4.45	0.28	damaging	0.15	damaging	4.03	23.70	deleterious	0.17	0.65	0.92	disease	0.82	disease	0.74	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.72	high_impact	0.69	0.9	48.67	8.89	0.78	P	1.00	disease_causing	0.99	0.32	.	.	.	.	.	.	.	.	.	T9035C	Ataxia syndromes	+	+	Cfrm	2	.	P	P	damaging
chrM	3350	3350	T	G	MI.10850	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	44	15	I	S	aTc/aGc	-0.7	0	0	benign	0.22	neutral	0.24	neutral	2.69	neutral	-2.09	deleterious	-3.94	medium_impact	3.12	0.74	neutral	0.45	neutral	4.07	23.70	deleterious	0.07	0.35	NA	NA	0.68	disease	0.51	disease	0.57	disease	1	0.71	neutral	0.51	deleterious	-3	neutral	0.29	neutral	-0.24	medium_impact	-0.01	medium_impact	1.54	medium_impact	0.22	0.8	27.36	46.43	0.43	N	0.59	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3351	3351	C	G	MI.10851	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	45	15	I	M	atC/atG	5.5	0.86	0	possibly_damaging	0.55	neutral	0.18	neutral	2.67	neutral	-1.67	neutral	-0.61	low_impact	1.68	0.86	neutral	0.63	neutral	3.15	22.60	deleterious	0.3	0.45	NA	NA	0.47	neutral	0.38	neutral	0.33	neutral	3	0.81	neutral	0.32	neutral	-3	neutral	0.53	deleterious	-0.83	medium_impact	-0.09	medium_impact	0.28	medium_impact	0.31	0.8	27.36	46.43	0.51	P	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3351	3351	C	A	MI.10852	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	45	15	I	M	atC/atA	5.5	0.86	0	possibly_damaging	0.55	neutral	0.18	neutral	2.67	neutral	-1.67	neutral	-0.61	low_impact	1.68	0.86	neutral	0.63	neutral	3.63	23.20	deleterious	0.3	0.45	NA	NA	0.47	neutral	0.38	neutral	0.33	neutral	3	0.81	neutral	0.32	neutral	-3	neutral	0.53	deleterious	-0.83	medium_impact	-0.09	medium_impact	0.28	medium_impact	0.31	0.8	27.36	46.43	0.51	P	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3352	3352	G	T	MI.10853	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	46	16	A	S	Gca/Tca	-3.23	0	0	probably_damaging	1	neutral	0.14	neutral	2.82	neutral	-1.55	deleterious	-2.64	low_impact	1.74	0.73	neutral	0.13	damaging	3.48	23.10	deleterious	0.28	0.45	NA	NA	0.61	disease	0.24	neutral	0.42	neutral	2	1	deleterious	0.07	neutral	-2	neutral	0.82	deleterious	-3.57	low_impact	-0.17	medium_impact	0.33	medium_impact	0.34	0.8	59.12	10.11	0.36	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3352	3352	G	A	MI.10854	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	46	16	A	T	Gca/Aca	-3.23	0	0	probably_damaging	1	neutral	0.1	neutral	2.66	neutral	-1.93	deleterious	-3.54	medium_impact	2.71	0.69	neutral	0.1	damaging	4.01	23.60	deleterious	0.24	0.45	NA	NA	0.74	disease	0.52	disease	0.57	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	-0.26	medium_impact	1.18	medium_impact	0.62	0.8	59.12	10.11	0.37	N	0.70	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3352	3352	G	C	MI.10855	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	46	16	A	P	Gca/Cca	-3.23	0	0	probably_damaging	1	neutral	0.17	neutral	2.6	deleterious	-3.67	deleterious	-4.44	high_impact	3.56	0.71	neutral	0.1	damaging	3.61	23.20	deleterious	0.08	0.35	NA	NA	0.9	disease	0.65	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	-0.11	medium_impact	1.92	medium_impact	0.46	0.8	59.12	10.11	0.37	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3353	3353	C	T	MI.10856	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	47	16	A	V	gCa/gTa	5.04	1	0	probably_damaging	1	neutral	0.64	neutral	2.64	neutral	-1.33	deleterious	-3.56	medium_impact	2.69	0.68	neutral	0.1	damaging	4.26	23.90	deleterious	0.21	0.45	NA	NA	0.85	disease	0.51	disease	0.69	disease	4	1	deleterious	0.32	neutral	1	deleterious	0.87	deleterious	-3.57	low_impact	0.42	medium_impact	1.16	medium_impact	0.55	0.8	59.12	10.11	0.52	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3353	3353	C	G	MI.10857	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	47	16	A	G	gCa/gGa	5.04	1	0	probably_damaging	1	neutral	0.07	neutral	2.73	neutral	-1.75	deleterious	-3.55	medium_impact	2.02	0.84	neutral	0.15	damaging	3.74	23.30	deleterious	0.28	0.45	NA	NA	0.61	disease	0.24	neutral	0.42	neutral	2	1	deleterious	0.04	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	-0.35	medium_impact	0.58	medium_impact	0.61	0.8	59.12	10.11	0.53	N	0.79	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3353	3353	C	A	MI.10858	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	47	16	A	E	gCa/gAa	5.04	1	0	probably_damaging	1	deleterious	0.03	neutral	2.68	deleterious	-3.22	deleterious	-4.43	high_impact	3.91	0.76	neutral	0.12	damaging	4.28	24.00	deleterious	0.08	0.35	NA	NA	0.9	disease	0.64	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-3.57	low_impact	-0.57	medium_impact	2.23	high_impact	0.29	0.8	59.12	10.11	0.56	P	0.96	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3355	3355	A	T	MI.10859	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	49	17	M	L	Atg/Ttg	-6.44	0	0	probably_damaging	0.98	neutral	0.71	neutral	2.94	neutral	1.74	neutral	-0.35	low_impact	1.03	0.68	neutral	0.61	neutral	3.12	22.60	deleterious	0.27	0.45	NA	NA	0.7	disease	0.45	neutral	0.53	disease	1	0.98	deleterious	0.37	neutral	-2	neutral	0.84	deleterious	-2.34	low_impact	0.49	medium_impact	-0.29	medium_impact	0.26	0.8	23.58	36.17	0.35	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9037	9037	A	G	MI.1086	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	511	171	M	V	Atg/Gtg	-6.35	0	0	possibly_damaging	0.87	neutral	0.1	neutral	4.52	neutral	0.18	neutral	-0.49	low_impact	1.76	0.8	neutral	0.6	neutral	2.79	21.30	deleterious	0.27	0.65	0.3	neutral	0.75	disease	0.48	neutral	0.55	disease	1	0.96	neutral	0.12	neutral	-3	neutral	0.57	deleterious	-1.54	low_impact	-0.25	medium_impact	0.41	medium_impact	0.55	0.9	17.26	16.43	0.31	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3355	3355	A	G	MI.10860	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	49	17	M	V	Atg/Gtg	-6.44	0	0	probably_damaging	0.99	neutral	1	neutral	3.27	neutral	3.32	neutral	1.71	neutral_impact	-2.11	0.74	neutral	0.96	neutral	-0.27	0.79	neutral	0.31	0.5	NA	NA	0.21	neutral	0.3	neutral	0.16	neutral	7	0.99	deleterious	0.51	deleterious	-2	neutral	0.70	deleterious	-2.62	low_impact	1.96	high_impact	-3.03	low_impact	0.27	0.8	23.58	36.17	0.25	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3355	3355	A	C	MI.10861	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	49	17	M	L	Atg/Ctg	-6.44	0	0	probably_damaging	0.98	neutral	0.71	neutral	2.94	neutral	1.74	neutral	-0.35	low_impact	1.03	0.68	neutral	0.61	neutral	3.06	22.40	deleterious	0.27	0.45	NA	NA	0.7	disease	0.45	neutral	0.53	disease	1	0.98	deleterious	0.37	neutral	-2	neutral	0.84	deleterious	-2.34	low_impact	0.49	medium_impact	-0.29	medium_impact	0.26	0.8	23.58	36.17	0.35	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3356	3356	T	C	MI.10862	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	50	17	M	T	aTg/aCg	5.04	1	0	probably_damaging	1	neutral	0.09	neutral	2.81	neutral	0.07	neutral	-1.31	low_impact	1.53	0.63	neutral	0.72	neutral	2.73	21.00	deleterious	0.16	0.45	NA	NA	0.6	disease	0.49	neutral	0.48	neutral	0	1	deleterious	0.05	neutral	-2	neutral	0.84	deleterious	-3.57	low_impact	-0.29	medium_impact	0.15	medium_impact	0.14	0.8	23.58	36.17	0.63	P	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3356	3356	T	A	MI.10863	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	50	17	M	K	aTg/aAg	5.04	1	0	probably_damaging	1	neutral	0.09	neutral	2.78	neutral	-0.83	deleterious	-2.96	medium_impact	2.5	0.64	neutral	0.47	neutral	3.86	23.50	deleterious	0.06	0.35	NA	NA	0.88	disease	0.63	disease	0.81	disease	6	1	deleterious	0.05	neutral	1	deleterious	0.90	deleterious	-3.57	low_impact	-0.29	medium_impact	1	medium_impact	0.20	0.8	23.58	36.17	0.61	P	0.95	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3357	3357	G	C	MI.10864	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	51	17	M	I	atG/atC	7.34	1	0	probably_damaging	0.99	neutral	0.55	neutral	2.98	neutral	2.04	neutral	0.96	neutral_impact	0.13	0.78	neutral	0.57	neutral	3.28	22.80	deleterious	0.31	0.45	NA	NA	0.71	disease	0.45	neutral	0.52	disease	0	0.99	deleterious	0.28	neutral	-2	neutral	0.86	deleterious	-2.62	low_impact	0.32	medium_impact	-1.08	low_impact	0.29	0.8	23.58	36.17	0.46	N	0.48	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3357	3357	G	T	MI.10865	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	51	17	M	I	atG/atT	7.34	1	0	probably_damaging	0.99	neutral	0.55	neutral	2.98	neutral	2.04	neutral	0.96	neutral_impact	0.13	0.78	neutral	0.57	neutral	3.39	23.00	deleterious	0.31	0.45	NA	NA	0.71	disease	0.45	neutral	0.52	disease	0	0.99	deleterious	0.28	neutral	-2	neutral	0.86	deleterious	-2.62	low_impact	0.32	medium_impact	-1.08	low_impact	0.29	0.8	23.58	36.17	0.47	N	0.48	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3358	3358	G	A	MI.10866	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	52	18	A	T	Gca/Aca	-0.93	0.07	0	probably_damaging	1	neutral	0.28	neutral	2.5	neutral	-2.63	deleterious	-3.54	medium_impact	3.41	0.71	neutral	0.46	neutral	4.02	23.60	deleterious	0.16	0.45	NA	NA	0.83	disease	0.54	disease	0.7	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.90	deleterious	-3.57	low_impact	0.05	medium_impact	1.79	medium_impact	0.58	0.8	60.38	9.95	0.48	N	0.70	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3358	3358	G	T	MI.10867	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	52	18	A	S	Gca/Tca	-0.93	0.07	0	probably_damaging	1	neutral	0.37	neutral	2.5	neutral	-2.68	deleterious	-2.65	high_impact	3.56	0.68	neutral	0.53	neutral	3.48	23.10	deleterious	0.24	0.45	NA	NA	0.84	disease	0.51	disease	0.65	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.15	medium_impact	1.92	medium_impact	0.39	0.8	60.38	9.95	0.45	N	0.93	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3358	3358	G	C	MI.10868	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	52	18	A	P	Gca/Cca	-0.93	0.07	0	probably_damaging	1	neutral	0.41	neutral	2.45	deleterious	-4.34	deleterious	-4.44	high_impact	4.76	0.67	neutral	0.41	neutral	3.61	23.20	deleterious	0.05	0.35	NA	NA	0.91	disease	0.72	disease	0.77	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.93	deleterious	-3.57	low_impact	0.19	medium_impact	2.97	high_impact	0.48	0.8	60.38	9.95	0.72	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3359	3359	C	G	MI.10869	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	53	18	A	G	gCa/gGa	7.11	1	0	probably_damaging	1	neutral	0.3	neutral	2.46	deleterious	-3.67	deleterious	-3.55	medium_impact	3.17	0.8	neutral	0.53	neutral	3.74	23.30	deleterious	0.28	0.45	NA	NA	0.82	disease	0.52	disease	0.51	disease	0	1	deleterious	0.15	neutral	1	deleterious	0.88	deleterious	-3.57	low_impact	0.07	medium_impact	1.58	medium_impact	0.60	0.8	60.38	9.95	0.58	P	0.79	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9037	9037	A	T	MI.1087	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	511	171	M	L	Atg/Ttg	-6.35	0	0	possibly_damaging	0.81	neutral	0.84	neutral	4.65	neutral	2.27	neutral	-0.56	neutral_impact	0.53	0.84	neutral	0.82	neutral	2.30	18.16	deleterious	0.25	0.65	0.26	neutral	0.62	disease	0.43	neutral	0.47	neutral	1	0.78	neutral	0.52	deleterious	-3	neutral	0.53	deleterious	-1.35	low_impact	0.7	medium_impact	-0.64	medium_impact	0.54	0.9	17.26	16.43	0.26	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3359	3359	C	A	MI.10870	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	53	18	A	E	gCa/gAa	7.11	1	0	probably_damaging	1	neutral	0.17	neutral	2.48	deleterious	-3.21	deleterious	-4.43	high_impact	4.76	0.72	neutral	0.41	neutral	4.23	23.90	deleterious	0.05	0.35	NA	NA	0.92	disease	0.71	disease	0.78	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	-0.11	medium_impact	2.97	high_impact	0.20	0.8	60.38	9.95	0.76	P	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3359	3359	C	T	MI.10871	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	53	18	A	V	gCa/gTa	7.11	1	0	probably_damaging	1	neutral	0.75	neutral	2.59	neutral	-1.39	deleterious	-3.56	medium_impact	3.48	0.65	neutral	0.45	neutral	4.30	24.00	deleterious	0.14	0.4	NA	NA	0.9	disease	0.61	disease	0.71	disease	4	1	deleterious	0.38	neutral	1	deleterious	0.92	deleterious	-3.57	low_impact	0.54	medium_impact	1.85	medium_impact	0.57	0.8	60.38	9.95	0.6	P	0.72	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3361	3361	T	G	MI.10872	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	55	19	F	V	Ttc/Gtc	-4.61	0	0	probably_damaging	1	neutral	1	neutral	2.71	neutral	-0.54	deleterious	-5.61	medium_impact	3.36	0.71	neutral	0.15	damaging	3.94	23.50	deleterious	0.12	0.4	NA	NA	0.92	disease	0.62	disease	0.73	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.88	deleterious	-3.57	low_impact	1.96	high_impact	1.75	medium_impact	0.17	0.8	60.06	10.21	0.3	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3361	3361	T	A	MI.10873	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	55	19	F	I	Ttc/Atc	-4.61	0	0	probably_damaging	1	neutral	0.46	neutral	2.62	neutral	-1.24	deleterious	-4.72	high_impact	3.64	0.76	neutral	0.19	damaging	4.22	23.90	deleterious	0.17	0.45	NA	NA	0.9	disease	0.57	disease	0.68	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.24	medium_impact	1.99	medium_impact	0.30	0.8	60.06	10.21	0.42	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3361	3361	T	C	MI.10874	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	55	19	F	L	Ttc/Ctc	-4.61	0	0	probably_damaging	1	neutral	0.77	neutral	2.79	neutral	-0.08	deleterious	-4.6	medium_impact	3	0.82	neutral	0.22	damaging	3.81	23.40	deleterious	0.2	0.45	NA	NA	0.83	disease	0.44	neutral	0.51	disease	0	1	deleterious	0.39	neutral	1	deleterious	0.84	deleterious	-3.57	low_impact	0.57	medium_impact	1.43	medium_impact	0.57	0.8	60.06	10.21	0.29	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3362	3362	T	C	MI.10875	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	56	19	F	S	tTc/tCc	4.35	1	0	probably_damaging	1	neutral	0.21	neutral	2.5	deleterious	-3.35	deleterious	-6.68	high_impact	4.13	0.76	neutral	0.18	damaging	4.10	23.70	deleterious	0.04	0.35	NA	NA	0.9	disease	0.61	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.05	medium_impact	2.42	high_impact	0.17	0.8	60.06	10.21	0.59	P	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3362	3362	T	G	MI.10876	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	56	19	F	C	tTc/tGc	4.35	1	0	probably_damaging	1	neutral	0.07	neutral	2.48	deleterious	-4.57	deleterious	-6.6	high_impact	4.68	0.76	neutral	0.15	damaging	3.91	23.50	deleterious	0.05	0.35	NA	NA	0.88	disease	0.64	disease	0.72	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.35	medium_impact	2.9	high_impact	0.15	0.8	60.06	10.21	0.61	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3362	3362	T	A	MI.10877	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	56	19	F	Y	tTc/tAc	4.35	1	0	probably_damaging	1	neutral	0.15	neutral	2.5	deleterious	-3.37	deleterious	-2.52	medium_impact	2.37	0.85	neutral	0.18	damaging	4.21	23.90	deleterious	0.2	0.45	NA	NA	0.77	disease	0.44	neutral	0.5	disease	0	1	deleterious	0.08	neutral	1	deleterious	0.85	deleterious	-3.57	low_impact	-0.15	medium_impact	0.88	medium_impact	0.48	0.8	60.06	10.21	0.54	N	0.88	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3363	3363	C	G	MI.10878	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	57	19	F	L	ttC/ttG	4.58	1	0	probably_damaging	1	neutral	0.77	neutral	2.79	neutral	-0.08	deleterious	-4.6	medium_impact	3	0.82	neutral	0.22	damaging	4.14	23.80	deleterious	0.2	0.45	NA	NA	0.83	disease	0.44	neutral	0.51	disease	0	1	deleterious	0.39	neutral	1	deleterious	0.84	deleterious	-3.57	low_impact	0.57	medium_impact	1.43	medium_impact	0.57	0.8	60.06	10.21	0.44	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3363	3363	C	A	MI.10879	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	57	19	F	L	ttC/ttA	4.58	1	0	probably_damaging	1	neutral	0.77	neutral	2.79	neutral	-0.08	deleterious	-4.6	medium_impact	3	0.82	neutral	0.22	damaging	4.46	24.20	deleterious	0.2	0.45	NA	NA	0.83	disease	0.44	neutral	0.51	disease	0	1	deleterious	0.39	neutral	1	deleterious	0.84	deleterious	-3.57	low_impact	0.57	medium_impact	1.43	medium_impact	0.57	0.8	60.06	10.21	0.44	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9037	9037	A	C	MI.1088	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	511	171	M	L	Atg/Ctg	-6.35	0	0	possibly_damaging	0.81	neutral	0.84	neutral	4.65	neutral	2.27	neutral	-0.56	neutral_impact	0.53	0.84	neutral	0.82	neutral	2.29	18.08	deleterious	0.25	0.65	0.26	neutral	0.62	disease	0.43	neutral	0.47	neutral	1	0.78	neutral	0.52	deleterious	-3	neutral	0.53	deleterious	-1.35	low_impact	0.7	medium_impact	-0.64	medium_impact	0.54	0.9	17.26	16.43	0.26	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3364	3364	C	G	MI.10880	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	58	20	L	V	Cta/Gta	-3.23	0	0	possibly_damaging	0.86	neutral	0.44	neutral	2.39	neutral	-1.71	deleterious	-2.56	medium_impact	2.9	0.66	neutral	0.07	damaging	3.22	22.70	deleterious	0.31	0.45	NA	NA	0.7	disease	0.35	neutral	0.5	neutral	0	0.85	neutral	0.29	neutral	0	NA	0.81	deleterious	-1.49	low_impact	0.22	medium_impact	1.34	medium_impact	0.44	0.8	60.38	10.28	0.26	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3364	3364	C	A	MI.10881	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	58	20	L	M	Cta/Ata	-3.23	0	0	probably_damaging	0.98	neutral	0.06	neutral	2.29	neutral	-2.65	neutral	-1.66	medium_impact	2.85	0.66	neutral	0.08	damaging	3.52	23.10	deleterious	0.27	0.45	NA	NA	0.68	disease	0.47	neutral	0.47	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.82	deleterious	-2.34	low_impact	-0.4	medium_impact	1.3	medium_impact	0.37	0.8	60.38	10.28	0.3	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3365	3365	T	G	MI.10882	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	59	20	L	R	cTa/cGa	0.68	0.26	0	probably_damaging	0.98	deleterious	0.04	neutral	2.18	deleterious	-5.48	deleterious	-5.17	high_impact	4.46	0.5	damaging	0.05	damaging	3.96	23.60	deleterious	0.02	0.35	NA	NA	0.93	disease	0.71	disease	0.82	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.94	deleterious	-2.34	low_impact	-0.5	medium_impact	2.71	high_impact	0.16	0.8	60.38	10.28	0.46	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3365	3365	T	A	MI.10883	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	59	20	L	Q	cTa/cAa	0.68	0.26	0	probably_damaging	0.99	deleterious	0.04	neutral	2.18	deleterious	-5.47	deleterious	-5.17	high_impact	4.46	0.54	damaging	0.06	damaging	3.89	23.50	deleterious	0.04	0.35	NA	NA	0.85	disease	0.59	disease	0.7	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.87	deleterious	-2.62	low_impact	-0.5	medium_impact	2.71	high_impact	0.18	0.8	60.38	10.28	0.42	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3365	3365	T	C	MI.10884	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	59	20	L	P	cTa/cCa	0.68	0.26	0	probably_damaging	0.99	neutral	0.08	neutral	2.18	deleterious	-6.02	deleterious	-6.07	high_impact	4.46	0.44	damaging	0.06	damaging	3.72	23.30	deleterious	0.02	0.35	NA	NA	0.89	disease	0.71	disease	0.78	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.93	deleterious	-2.62	low_impact	-0.32	medium_impact	2.71	high_impact	0.21	0.8	60.38	10.28	0.51	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3367	3367	A	G	MI.10885	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	61	21	M	V	Atg/Gtg	-16.09	0	0	benign	0.02	neutral	0.5	neutral	3.04	neutral	2.19	neutral	0.76	neutral_impact	-2.02	0.61	neutral	0.69	neutral	2.47	19.25	deleterious	0.23	0.45	NA	NA	0.71	disease	0.39	neutral	0.51	disease	0	0.48	neutral	0.74	deleterious	-6	neutral	0.29	neutral	0.84	medium_impact	0.28	medium_impact	-2.95	low_impact	0.22	0.8	54.4	10	0.35	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3367	3367	A	C	MI.10886	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	61	21	M	L	Atg/Ctg	-16.09	0	0	benign	0.02	neutral	1	neutral	2.87	neutral	1.7	neutral	-0.08	neutral_impact	-0.98	0.63	neutral	0.55	neutral	3.07	22.50	deleterious	0.21	0.45	NA	NA	0.69	disease	0.45	neutral	0.49	neutral	0	0.02	neutral	0.99	deleterious	-6	neutral	0.29	neutral	0.84	medium_impact	1.96	high_impact	-2.04	low_impact	0.22	0.8	54.4	10	0.28	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3367	3367	A	T	MI.10887	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	61	21	M	L	Atg/Ttg	-16.09	0	0	benign	0.02	neutral	1	neutral	2.87	neutral	1.7	neutral	-0.08	neutral_impact	-0.98	0.63	neutral	0.55	neutral	3.09	22.50	deleterious	0.21	0.45	NA	NA	0.69	disease	0.45	neutral	0.49	neutral	0	0.02	neutral	0.99	deleterious	-6	neutral	0.29	neutral	0.84	medium_impact	1.96	high_impact	-2.04	low_impact	0.22	0.8	54.4	10	0.28	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3368	3368	T	C	MI.10888	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	62	21	M	T	aTg/aCg	8.49	1	0.01	benign	0	neutral	0.33	neutral	3.03	neutral	2.2	neutral	5.02	neutral_impact	-4.74	0.69	neutral	0.75	neutral	0.09	3.48	deleterious	0.15	0.4	NA	NA	0.12	neutral	0.27	neutral	0.18	neutral	6	0.67	neutral	0.67	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.1	medium_impact	-5.33	low_impact	0.12	0.8	54.4	10	0.57	P	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3368	3368	T	A	MI.10889	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	62	21	M	K	aTg/aAg	8.49	1	0.01	benign	0.11	neutral	0.05	neutral	2.82	neutral	-0.52	neutral	-0.16	neutral_impact	0	0.62	neutral	0.5	neutral	3.93	23.50	deleterious	0.06	0.35	NA	NA	0.85	disease	0.57	disease	0.76	disease	5	0.94	neutral	0.47	deleterious	-6	neutral	0.39	neutral	0.1	medium_impact	-0.44	medium_impact	-1.19	low_impact	0.19	0.8	54.4	10	0.6	P	0.63	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9038	9038	T	C	MI.1089	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	512	171	M	T	aTg/aCg	5.68	1	0	probably_damaging	0.94	deleterious	0	neutral	4.34	neutral	-1.27	deleterious	-3.25	medium_impact	2.31	0.84	neutral	0.59	neutral	3.02	22.30	deleterious	0.23	0.65	0.69	disease	0.76	disease	0.62	disease	0.72	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.77	deleterious	-1.89	low_impact	-1.4	low_impact	0.88	medium_impact	0.46	0.9	17.26	16.43	0.45	N	0.87	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3369	3369	G	T	MI.10890	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	63	21	M	I	atG/atT	3.44	0.99	0	benign	0	neutral	0.32	neutral	2.87	neutral	1.7	neutral	-0.11	neutral_impact	-1.94	0.82	neutral	0.57	neutral	3.39	23.00	deleterious	0.27	0.45	NA	NA	0.71	disease	0.39	neutral	0.49	neutral	0	0.68	neutral	0.66	deleterious	-6	neutral	0.30	neutral	2.07	high_impact	0.09	medium_impact	-2.88	low_impact	0.30	0.8	54.4	10	0.36	N	0.42	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3369	3369	G	C	MI.10891	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	63	21	M	I	atG/atC	3.44	0.99	0	benign	0	neutral	0.32	neutral	2.87	neutral	1.7	neutral	-0.11	neutral_impact	-1.94	0.82	neutral	0.57	neutral	3.25	22.80	deleterious	0.27	0.45	NA	NA	0.71	disease	0.39	neutral	0.49	neutral	0	0.68	neutral	0.66	deleterious	-6	neutral	0.30	neutral	2.07	high_impact	0.09	medium_impact	-2.88	low_impact	0.30	0.8	54.4	10	0.35	N	0.42	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3370	3370	C	G	MI.10892	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	64	22	L	V	Ctt/Gtt	-11.27	0	0	probably_damaging	1	neutral	1	neutral	2.4	neutral	-2.56	deleterious	-2.68	medium_impact	3.24	0.79	neutral	0.16	damaging	3.22	22.70	deleterious	0.29	0.45	NA	NA	0.77	disease	0.61	disease	0.67	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.89	deleterious	-3.57	low_impact	1.96	high_impact	1.64	medium_impact	0.61	0.8	59.75	10.36	0.17	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3370	3370	C	T	MI.10893	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	64	22	L	F	Ctt/Ttt	-11.27	0	0	probably_damaging	1	neutral	0.69	neutral	2.46	neutral	-1.89	deleterious	-3.57	medium_impact	3.24	0.66	neutral	0.13	damaging	3.76	23.30	deleterious	0.14	0.4	NA	NA	0.79	disease	0.55	disease	0.67	disease	3	1	deleterious	0.35	neutral	1	deleterious	0.89	deleterious	-3.57	low_impact	0.47	medium_impact	1.64	medium_impact	0.56	0.8	59.75	10.36	0.25	N	0.95	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3370	3370	C	A	MI.10894	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	64	22	L	I	Ctt/Att	-11.27	0	0	probably_damaging	1	neutral	0.57	neutral	2.4	neutral	-2.64	neutral	-1.79	medium_impact	3	0.76	neutral	0.16	damaging	3.93	23.50	deleterious	0.33	0.5	NA	NA	0.8	disease	0.6	disease	0.68	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.89	deleterious	-3.57	low_impact	0.34	medium_impact	1.43	medium_impact	0.48	0.8	59.75	10.36	0.26	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3371	3371	T	G	MI.10895	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	65	22	L	R	cTt/cGt	-2.54	0	0	probably_damaging	1	neutral	0.05	neutral	2.33	deleterious	-4.49	deleterious	-5.36	high_impact	4.71	0.72	neutral	0.11	damaging	4.00	23.60	deleterious	0.02	0.35	NA	NA	0.94	disease	0.73	disease	0.85	disease	7	1	deleterious	0.03	neutral	2	deleterious	0.94	deleterious	-3.57	low_impact	-0.44	medium_impact	2.93	high_impact	0.19	0.8	59.75	10.36	0.61	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3371	3371	T	A	MI.10896	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	65	22	L	H	cTt/cAt	-2.54	0	0	probably_damaging	1	neutral	0.07	neutral	2.33	deleterious	-4.34	deleterious	-6.25	high_impact	4.71	0.71	neutral	0.12	damaging	3.90	23.50	deleterious	0.04	0.35	NA	NA	0.86	disease	0.7	disease	0.74	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	-0.35	medium_impact	2.93	high_impact	0.23	0.8	59.75	10.36	0.59	P	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3371	3371	T	C	MI.10897	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	65	22	L	P	cTt/cCt	-2.54	0	0	probably_damaging	1	deleterious	0.03	neutral	2.32	deleterious	-5.21	deleterious	-6.25	high_impact	4.71	0.72	neutral	0.13	damaging	3.69	23.30	deleterious	0.02	0.35	NA	NA	0.87	disease	0.73	disease	0.78	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.94	deleterious	-3.57	low_impact	-0.57	medium_impact	2.93	high_impact	0.24	0.8	59.75	10.36	0.56	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3373	3373	A	T	MI.10898	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	67	23	T	S	Acc/Tcc	-3.69	0	0	benign	0.18	neutral	0.14	neutral	2.79	neutral	-0.93	neutral	-1.22	neutral_impact	0.6	0.68	neutral	0.63	neutral	3.10	22.50	deleterious	0.37	0.5	NA	NA	0.48	neutral	0.33	neutral	0.35	neutral	3	0.84	neutral	0.48	deleterious	-6	neutral	0.28	neutral	-0.13	medium_impact	-0.17	medium_impact	-0.66	medium_impact	0.70	0.85	27.04	28.71	0.45	N	0.27	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3373	3373	A	G	MI.10899	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	67	23	T	A	Acc/Gcc	-3.69	0	0	benign	0.01	neutral	0.79	neutral	2.86	neutral	1.5	neutral	-0.08	neutral_impact	-0.42	0.9	neutral	0.92	neutral	2.21	17.60	deleterious	0.26	0.45	NA	NA	0.38	neutral	0.14	neutral	0.17	neutral	7	0.18	neutral	0.89	deleterious	-6	neutral	0.18	neutral	1.12	medium_impact	0.6	medium_impact	-1.56	low_impact	0.41	0.8	27.04	28.71	0.4	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8576	8576	T	G	MI.109	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	50	17	L	R	cTa/cGa	-0.57	0	0	probably_damaging	1	deleterious	0.02	neutral	4.41	deleterious	-4.15	deleterious	-4.38	medium_impact	2.77	0.83	neutral	0.39	neutral	3.99	23.60	deleterious	0.18	0.65	0.88	disease	0.91	disease	0.73	disease	0.84	disease	7	1	deleterious	0.01	neutral	5	deleterious	0.90	deleterious	-3.6	low_impact	-0.66	medium_impact	1.28	medium_impact	0.66	0.9	28.76	21.22	0.29	N	0.77	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9038	9038	T	A	MI.1090	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	512	171	M	K	aTg/aAg	5.68	1	0	probably_damaging	0.94	deleterious	0	neutral	4.3	neutral	-2.77	deleterious	-4.31	medium_impact	2.94	0.77	neutral	0.42	neutral	4.14	23.80	deleterious	0.11	0.65	0.83	disease	0.9	disease	0.7	disease	0.79	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.84	deleterious	-1.89	low_impact	-1.4	low_impact	1.42	medium_impact	0.45	0.9	17.26	16.43	0.47	N	0.95	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3373	3373	A	C	MI.10900	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	67	23	T	P	Acc/Ccc	-3.69	0	0	possibly_damaging	0.62	neutral	0.09	neutral	2.74	neutral	-2.49	neutral	-1.93	low_impact	1.7	0.63	neutral	0.46	neutral	3.28	22.80	deleterious	0.04	0.35	NA	NA	0.88	disease	0.48	neutral	0.79	disease	6	0.91	neutral	0.24	neutral	-3	neutral	0.75	deleterious	-0.95	medium_impact	-0.29	medium_impact	0.3	medium_impact	0.38	0.8	27.04	28.71	0.39	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3374	3374	C	A	MI.10901	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	68	23	T	N	aCc/aAc	-2.31	0	0	possibly_damaging	0.62	neutral	0.08	neutral	2.75	neutral	-1.71	neutral	-2.2	low_impact	1.7	0.59	damaging	0.62	neutral	3.43	23.00	deleterious	0.19	0.45	NA	NA	0.71	disease	0.34	neutral	0.5	disease	0	0.92	neutral	0.23	neutral	-3	neutral	0.69	deleterious	-0.95	medium_impact	-0.32	medium_impact	0.3	medium_impact	0.61	0.8	27.04	28.71	0.41	N	0.75	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3374	3374	C	T	MI.10902	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	68	23	T	I	aCc/aTc	-2.31	0	0	benign	0.01	neutral	0.2	neutral	2.85	neutral	1.2	neutral	2.31	neutral_impact	-1.26	0.87	neutral	0.96	neutral	1.70	14.41	neutral	0.09	0.35	NA	NA	0.53	disease	0.14	neutral	0.42	neutral	2	0.8	neutral	0.6	deleterious	-6	neutral	0.20	neutral	1.12	medium_impact	-0.06	medium_impact	-2.29	low_impact	0.59	0.8	27.04	28.71	0.45	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3374	3374	C	G	MI.10903	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	68	23	T	S	aCc/aGc	-2.31	0	0	benign	0.18	neutral	0.14	neutral	2.79	neutral	-0.93	neutral	-1.22	neutral_impact	0.6	0.68	neutral	0.63	neutral	3.30	22.90	deleterious	0.37	0.5	NA	NA	0.48	neutral	0.33	neutral	0.35	neutral	3	0.84	neutral	0.48	deleterious	-6	neutral	0.28	neutral	-0.13	medium_impact	-0.17	medium_impact	-0.66	medium_impact	0.70	0.85	27.04	28.71	0.44	N	0.27	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3376	3376	G	A	MI.10904	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	70	24	E	K	Gaa/Aaa	-5.75	0	0	probably_damaging	1	neutral	0.09	neutral	2.17	deleterious	-3.5	deleterious	-3.56	high_impact	4.17	0.72	neutral	0.14	damaging	4.29	24.00	deleterious	0.04	0.35	NA	NA	0.94	disease	0.65	disease	0.76	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.94	deleterious	-3.57	low_impact	-0.29	medium_impact	2.45	high_impact	0.54	0.8	59.12	10.27	0.5	N	0.99	disease_causing_automatic	0	0.46	rs397515612	Pathogenic	Leber's_optic_atrophy	76829	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	G3376A	LHON MELAS overlap	+	+	Cfrm	3	P	P	P	damaging
chrM	3376	3376	G	C	MI.10905	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	70	24	E	Q	Gaa/Caa	-5.75	0	0	probably_damaging	1	neutral	0.09	neutral	2.16	deleterious	-3.74	deleterious	-2.67	high_impact	4.51	0.68	neutral	0.14	damaging	3.19	22.70	deleterious	0.1	0.4	NA	NA	0.83	disease	0.66	disease	0.7	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.29	medium_impact	2.75	high_impact	0.70	0.85	59.12	10.27	0.48	N	0.91	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3377	3377	A	G	MI.10906	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	71	24	E	G	gAa/gGa	7.11	1	0	probably_damaging	1	neutral	0.13	neutral	2.14	deleterious	-4.15	deleterious	-6.24	high_impact	4.51	0.68	neutral	0.17	damaging	4.18	23.80	deleterious	0.03	0.35	NA	NA	0.86	disease	0.67	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	-0.19	medium_impact	2.75	high_impact	0.28	0.8	59.12	10.27	0.65	P	0.61	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3377	3377	A	C	MI.10907	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	71	24	E	A	gAa/gCa	7.11	1	0	probably_damaging	1	neutral	0.69	neutral	2.15	deleterious	-3.76	deleterious	-5.35	high_impact	4.86	0.69	neutral	0.16	damaging	3.51	23.10	deleterious	0.04	0.35	NA	NA	0.81	disease	0.64	disease	0.68	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.47	medium_impact	3.06	high_impact	0.32	0.8	59.12	10.27	0.71	P	0.74	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3377	3377	A	T	MI.10908	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	71	24	E	V	gAa/gTa	7.11	1	0	probably_damaging	1	neutral	0.61	neutral	2.11	deleterious	-5.16	deleterious	-6.24	high_impact	4.86	0.64	neutral	0.13	damaging	4.14	23.80	deleterious	0.02	0.35	NA	NA	0.93	disease	0.68	disease	0.74	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.93	deleterious	-3.57	low_impact	0.38	medium_impact	3.06	high_impact	0.24	0.8	59.12	10.27	0.69	P	0.83	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3378	3378	A	T	MI.10909	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	72	24	E	D	gaA/gaT	8.49	1	0	probably_damaging	1	neutral	0.07	neutral	2.29	neutral	-2.07	deleterious	-2.68	high_impact	3.82	0.77	neutral	0.15	damaging	3.62	23.20	deleterious	0.22	0.45	NA	NA	0.84	disease	0.55	disease	0.69	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.35	medium_impact	2.15	high_impact	0.55	0.8	59.12	10.27	0.61	P	0.90	polymorphism	0.99	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9039	9039	G	C	MI.1091	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	513	171	M	I	atG/atC	5.68	1	0.01	probably_damaging	0.91	neutral	1	neutral	4.48	neutral	0.57	neutral	0.03	neutral_impact	-0.4	0.81	neutral	0.97	neutral	0.90	10.05	neutral	0.3	0.65	0.35	neutral	0.2	neutral	0.35	neutral	0.35	neutral	3	0.91	neutral	0.55	deleterious	-2	neutral	0.60	deleterious	-1.71	low_impact	1.98	high_impact	-1.44	low_impact	0.64	0.9	17.26	16.43	0.47	N	0.05	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3378	3378	A	C	MI.10910	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	72	24	E	D	gaA/gaC	8.49	1	0	probably_damaging	1	neutral	0.07	neutral	2.29	neutral	-2.07	deleterious	-2.68	high_impact	3.82	0.77	neutral	0.15	damaging	3.50	23.10	deleterious	0.22	0.45	NA	NA	0.84	disease	0.55	disease	0.69	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.35	medium_impact	2.15	high_impact	0.55	0.8	59.12	10.27	0.61	P	0.90	polymorphism	0.99	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3379	3379	C	T	MI.10911	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	73	25	R	W	Cga/Tga	2.52	1	0	probably_damaging	1	neutral	0.11	neutral	1.6	deleterious	-9.89	deleterious	-7.14	high_impact	4.87	0.56	damaging	0.22	damaging	5.01	25.10	deleterious	0.06	0.35	NA	NA	0.91	disease	0.73	disease	0.77	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.23	medium_impact	3.06	high_impact	0.61	0.8	58.49	10.61	0.59	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3379	3379	C	G	MI.10912	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	73	25	R	G	Cga/Gga	2.52	1	0	probably_damaging	1	neutral	0.24	neutral	1.63	deleterious	-7.11	deleterious	-6.24	high_impact	4.87	0.7	neutral	0.43	neutral	4.01	23.60	deleterious	0.03	0.35	NA	NA	0.84	disease	0.7	disease	0.75	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.01	medium_impact	3.06	high_impact	0.14	0.8	58.49	10.61	0.66	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3380	3380	G	A	MI.10913	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	74	25	R	Q	cGa/cAa	2.75	1	0	probably_damaging	1	neutral	0.23	neutral	1.65	deleterious	-5.9	deleterious	-3.56	high_impact	4.87	0.62	neutral	0.31	neutral	4.39	24.10	deleterious	0.06	0.35	NA	NA	0.85	disease	0.67	disease	0.71	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.02	medium_impact	3.06	high_impact	0.69	0.85	58.49	10.61	0.65	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	COSM1599866	.	.	G3380A	MELAS	-	+	Reported	1	.	P	P	damaging
chrM	3380	3380	G	T	MI.10914	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	74	25	R	L	cGa/cTa	2.75	1	0	probably_damaging	1	neutral	1	neutral	1.63	deleterious	-7.04	deleterious	-6.25	high_impact	4.87	0.55	damaging	0.34	neutral	4.16	23.80	deleterious	0.03	0.35	NA	NA	0.93	disease	0.7	disease	0.77	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.91	deleterious	-3.57	low_impact	1.96	high_impact	3.06	high_impact	0.10	0.8	58.49	10.61	0.63	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3380	3380	G	C	MI.10915	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	74	25	R	P	cGa/cCa	2.75	1	0	probably_damaging	1	neutral	0.15	neutral	1.61	deleterious	-6.81	deleterious	-6.25	high_impact	4.87	0.56	damaging	0.28	damaging	4.08	23.70	deleterious	0.02	0.35	NA	NA	0.9	disease	0.82	disease	0.82	disease	6	1	deleterious	0.08	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	-0.15	medium_impact	3.06	high_impact	0.11	0.8	58.49	10.61	0.68	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3382	3382	A	G	MI.10916	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	76	26	K	E	Aaa/Gaa	-0.7	0.1	0	probably_damaging	1	neutral	0.44	neutral	2.49	deleterious	-3.1	deleterious	-3.55	high_impact	4.12	0.8	neutral	0.2	damaging	3.89	23.50	deleterious	0.07	0.35	NA	NA	0.87	disease	0.65	disease	0.71	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.22	medium_impact	2.41	high_impact	0.31	0.8	60.38	10.44	0.39	N	0.92	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3382	3382	A	C	MI.10917	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	76	26	K	Q	Aaa/Caa	-0.7	0.1	0	probably_damaging	1	neutral	0.21	neutral	2.45	deleterious	-3.55	deleterious	-3.55	high_impact	3.84	0.73	neutral	0.16	damaging	3.34	22.90	deleterious	0.13	0.4	NA	NA	0.83	disease	0.64	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.05	medium_impact	2.17	high_impact	0.41	0.8	60.38	10.44	0.44	N	0.92	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3383	3383	A	C	MI.10918	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	77	26	K	T	aAa/aCa	8.49	1	0	probably_damaging	1	neutral	0.49	neutral	2.44	deleterious	-3.97	deleterious	-5.32	high_impact	4.46	0.69	neutral	0.14	damaging	3.26	22.80	deleterious	0.05	0.35	NA	NA	0.83	disease	0.6	disease	0.69	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.27	medium_impact	2.71	high_impact	0.23	0.8	60.38	10.44	0.59	P	0.82	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3383	3383	A	T	MI.10919	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	77	26	K	M	aAa/aTa	8.49	1	0	probably_damaging	1	neutral	0.15	neutral	2.38	deleterious	-5.41	deleterious	-5.33	high_impact	4.81	0.75	neutral	0.15	damaging	3.55	23.10	deleterious	0.04	0.35	NA	NA	0.88	disease	0.64	disease	0.72	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.15	medium_impact	3.01	high_impact	0.27	0.8	60.38	10.44	0.7	P	0.50	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9039	9039	G	T	MI.1092	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	513	171	M	I	atG/atT	5.68	1	0.01	probably_damaging	0.91	neutral	1	neutral	4.48	neutral	0.57	neutral	0.03	neutral_impact	-0.4	0.81	neutral	0.97	neutral	1.01	10.70	neutral	0.3	0.65	0.35	neutral	0.2	neutral	0.35	neutral	0.35	neutral	3	0.91	neutral	0.55	deleterious	-2	neutral	0.60	deleterious	-1.71	low_impact	1.98	high_impact	-1.44	low_impact	0.64	0.9	17.26	16.43	0.47	N	0.05	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3384	3384	A	T	MI.10920	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	78	26	K	N	aaA/aaT	8.49	1	0	probably_damaging	1	neutral	0.21	neutral	2.43	deleterious	-3.99	deleterious	-4.44	high_impact	4.46	0.74	neutral	0.15	damaging	3.70	23.30	deleterious	0.1	0.4	NA	NA	0.84	disease	0.58	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.05	medium_impact	2.71	high_impact	0.33	0.8	60.38	10.44	0.64	P	0.84	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3384	3384	A	C	MI.10921	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	78	26	K	N	aaA/aaC	8.49	1	0	probably_damaging	1	neutral	0.21	neutral	2.43	deleterious	-3.99	deleterious	-4.44	high_impact	4.46	0.74	neutral	0.15	damaging	3.64	23.20	deleterious	0.1	0.4	NA	NA	0.84	disease	0.58	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.05	medium_impact	2.71	high_impact	0.33	0.8	60.38	10.44	0.64	P	0.84	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3385	3385	A	G	MI.10922	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	79	27	I	V	Att/Gtt	1.83	0.91	0	benign	0.01	neutral	0.47	neutral	2.87	neutral	0.2	neutral	0.27	neutral_impact	0.13	0.75	neutral	0.96	neutral	-0.02	2.43	deleterious	0.52	0.6	NA	NA	0.09	neutral	0.12	neutral	0.24	neutral	5	0.52	neutral	0.73	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.25	medium_impact	-1.08	low_impact	0.46	0.8	26.42	33.35	0.48	N	0.08	polymorphism	1	0.01	rs879050714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3385	3385	A	C	MI.10923	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	79	27	I	L	Att/Ctt	1.83	0.91	0	benign	0.01	neutral	1	neutral	2.63	neutral	-0.81	neutral	-1.25	low_impact	0.82	0.84	neutral	0.77	neutral	2.24	17.76	deleterious	0.27	0.45	NA	NA	0.6	disease	0.17	neutral	0.44	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.19	neutral	1.12	medium_impact	1.96	high_impact	-0.47	medium_impact	0.57	0.8	26.42	33.35	0.25	N	0.13	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3385	3385	A	T	MI.10924	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	79	27	I	F	Att/Ttt	1.83	0.91	0	possibly_damaging	0.49	neutral	0.42	neutral	2.39	deleterious	-3.72	deleterious	-2.84	medium_impact	2.2	0.9	neutral	0.86	neutral	3.32	22.90	deleterious	0.08	0.35	NA	NA	0.77	disease	0.37	neutral	0.63	disease	3	0.56	neutral	0.47	neutral	0	NA	0.61	deleterious	-0.74	medium_impact	0.2	medium_impact	0.73	medium_impact	0.50	0.8	26.42	33.35	0.42	N	0.73	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3386	3386	T	G	MI.10925	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	80	27	I	S	aTt/aGt	-0.47	0.16	0	benign	0.36	neutral	0.34	neutral	2.37	deleterious	-4.44	deleterious	-4.09	medium_impact	3.12	0.69	neutral	0.47	neutral	4.21	23.90	deleterious	0.02	0.35	NA	NA	0.83	disease	0.52	disease	0.76	disease	5	0.6	neutral	0.49	deleterious	-3	neutral	0.46	deleterious	-0.52	medium_impact	0.11	medium_impact	1.54	medium_impact	0.25	0.8	26.42	33.35	0.42	N	0.84	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3386	3386	T	C	MI.10926	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	80	27	I	T	aTt/aCt	-0.47	0.16	0	benign	0.03	neutral	0.61	neutral	2.39	deleterious	-3.59	deleterious	-2.75	low_impact	1.9	0.82	neutral	0.95	neutral	2.24	17.74	deleterious	0.04	0.35	NA	NA	0.63	disease	0.27	neutral	0.46	neutral	1	0.35	neutral	0.79	deleterious	-6	neutral	0.19	neutral	0.67	medium_impact	0.38	medium_impact	0.47	medium_impact	0.19	0.8	26.42	33.35	0.29	N	0.77	polymorphism	1	0.12	.	.	.	.	.	MNGIE tissues	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3386	3386	T	A	MI.10927	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	80	27	I	N	aTt/aAt	-0.47	0.16	0	possibly_damaging	0.68	neutral	0.25	neutral	2.36	deleterious	-5.47	deleterious	-4.99	high_impact	3.58	0.67	neutral	0.45	neutral	4.49	24.30	deleterious	0.04	0.35	NA	NA	0.9	disease	0.51	disease	0.76	disease	5	0.79	neutral	0.29	neutral	1	deleterious	0.69	deleterious	-1.06	low_impact	0.01	medium_impact	1.94	medium_impact	0.24	0.8	26.42	33.35	0.45	N	0.89	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3387	3387	T	A	MI.10928	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	81	27	I	M	atT/atA	3.67	0.46	0	possibly_damaging	0.68	neutral	0.16	neutral	2.4	deleterious	-3.4	neutral	-1.26	medium_impact	2.72	0.84	neutral	0.97	neutral	2.50	19.49	deleterious	0.17	0.45	NA	NA	0.66	disease	0.18	neutral	0.43	neutral	1	0.86	neutral	0.24	neutral	0	NA	0.61	deleterious	-1.06	low_impact	-0.13	medium_impact	1.19	medium_impact	0.56	0.8	26.42	33.35	0.49	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3387	3387	T	G	MI.10929	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	81	27	I	M	atT/atG	3.67	0.46	0	possibly_damaging	0.68	neutral	0.16	neutral	2.4	deleterious	-3.4	neutral	-1.26	medium_impact	2.72	0.84	neutral	0.97	neutral	2.19	17.41	deleterious	0.17	0.45	NA	NA	0.66	disease	0.18	neutral	0.43	neutral	1	0.86	neutral	0.24	neutral	0	NA	0.61	deleterious	-1.06	low_impact	-0.13	medium_impact	1.19	medium_impact	0.56	0.8	26.42	33.35	0.49	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9040	9040	C	G	MI.1093	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	514	172	H	D	Cac/Gac	-7.04	0	0	possibly_damaging	0.56	neutral	0.2	neutral	4.39	neutral	-0.27	deleterious	-5.43	medium_impact	2.32	0.8	neutral	0.35	neutral	3.93	23.50	deleterious	0.23	0.65	0.6	disease	0.86	disease	0.69	disease	0.8	disease	6	0.79	neutral	0.32	neutral	0	NA	0.71	deleterious	-0.86	medium_impact	-0.05	medium_impact	0.89	medium_impact	0.49	0.9	49.56	8.68	0.24	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3388	3388	C	G	MI.10930	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	82	28	L	V	Cta/Gta	-7.59	0	0	probably_damaging	1	neutral	0.4	neutral	2.6	neutral	-0.26	deleterious	-2.61	high_impact	4.36	0.6	damaging	0.47	neutral	3.28	22.80	deleterious	0.28	0.45	NA	NA	0.73	disease	0.62	disease	0.66	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.18	medium_impact	2.62	high_impact	0.52	0.8	59.12	10.77	0.46	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3388	3388	C	A	MI.10931	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	82	28	L	M	Cta/Ata	-7.59	0	0	probably_damaging	1	neutral	0.12	neutral	2.56	neutral	-1.53	neutral	-1.75	medium_impact	2.77	0.6	neutral	0.61	neutral	3.59	23.20	deleterious	0.31	0.45	NA	NA	0.61	disease	0.3	neutral	0.44	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.81	deleterious	-3.57	low_impact	-0.21	medium_impact	1.23	medium_impact	0.55	0.8	59.12	10.77	0.45	N	0.89	disease_causing_automatic	0	0.04	rs387906730	Pathogenic	Deafness,_nonsyndromic_sensorineural,_mitochondrial	38953	MedGen:C3151897,OMIM:500008	.	.	.	.	C3388A	Materally Inherited Nonsyndromic Deafness	.	.	Reported	1	P	P	P	neutral
chrM	3389	3389	T	A	MI.10932	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	83	28	L	Q	cTa/cAa	-2.08	0	0	probably_damaging	1	neutral	0.22	neutral	2.5	deleterious	-3.13	deleterious	-5.33	high_impact	4.71	0.65	neutral	0.43	neutral	3.90	23.50	deleterious	0.02	0.35	NA	NA	0.85	disease	0.62	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.03	medium_impact	2.93	high_impact	0.14	0.8	59.12	10.77	0.63	P	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3389	3389	T	G	MI.10933	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	83	28	L	R	cTa/cGa	-2.08	0	0	probably_damaging	1	neutral	0.39	neutral	2.51	neutral	-1.97	deleterious	-5.34	high_impact	4.71	0.66	neutral	0.35	neutral	4.06	23.70	deleterious	0.01	0.35	NA	NA	0.91	disease	0.68	disease	0.74	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.93	deleterious	-3.57	low_impact	0.17	medium_impact	2.93	high_impact	0.10	0.8	59.12	10.77	0.62	P	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3389	3389	T	C	MI.10934	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	83	28	L	P	cTa/cCa	-2.08	0	0	probably_damaging	1	neutral	0.14	neutral	2.49	deleterious	-3.73	deleterious	-6.21	high_impact	4.71	0.65	neutral	0.43	neutral	3.77	23.40	deleterious	0.01	0.35	NA	NA	0.87	disease	0.74	disease	0.77	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.93	deleterious	-3.57	low_impact	-0.17	medium_impact	2.93	high_impact	0.09	0.8	59.12	10.77	0.64	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3391	3391	G	C	MI.10935	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	85	29	G	R	Ggc/Cgc	1.14	1	0.02	probably_damaging	1	neutral	0.46	neutral	2.44	deleterious	-4.91	deleterious	-6.83	high_impact	4.63	0.66	neutral	0.29	neutral	3.75	23.30	deleterious	0.01	0.35	NA	NA	0.91	disease	0.75	disease	0.79	disease	6	1	deleterious	0.23	neutral	2	deleterious	0.94	deleterious	-3.57	low_impact	0.24	medium_impact	2.86	high_impact	0.58	0.8	60.06	10.35	0.62	P	0.99	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3391	3391	G	A	MI.10936	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	85	29	G	S	Ggc/Agc	1.14	1	0.02	probably_damaging	1	neutral	0.48	neutral	2.55	neutral	-1.84	deleterious	-4.92	low_impact	1.84	0.74	neutral	0.47	neutral	2.97	22.10	deleterious	0.03	0.35	NA	NA	0.75	disease	0.36	neutral	0.49	neutral	0	1	deleterious	0.24	neutral	-2	neutral	0.87	deleterious	-3.57	low_impact	0.26	medium_impact	0.42	medium_impact	0.62	0.8	60.06	10.35	0.48	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	G3391A	LHON	+	-	Reported	1	.	.	.	neutral
chrM	3391	3391	G	T	MI.10937	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	85	29	G	C	Ggc/Tgc	1.14	1	0.02	probably_damaging	1	neutral	0.18	neutral	2.43	deleterious	-4.71	deleterious	-7.68	high_impact	4.63	0.68	neutral	0.29	neutral	4.00	23.60	deleterious	0.01	0.35	NA	NA	0.91	disease	0.63	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	-0.09	medium_impact	2.86	high_impact	0.23	0.8	60.06	10.35	0.61	P	0.98	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3392	3392	G	C	MI.10938	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	86	29	G	A	gGc/gCc	5.96	1	0	probably_damaging	1	neutral	0.61	neutral	2.85	neutral	2.63	deleterious	-5.03	medium_impact	2.31	0.74	neutral	0.53	neutral	2.97	22.10	deleterious	0.07	0.35	NA	NA	0.74	disease	0.43	neutral	0.49	neutral	0	1	deleterious	0.31	neutral	1	deleterious	0.87	deleterious	-3.57	low_impact	0.38	medium_impact	0.83	medium_impact	0.43	0.8	60.06	10.35	0.51	N	0.76	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3392	3392	G	A	MI.10939	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	86	29	G	D	gGc/gAc	5.96	1	0	probably_damaging	1	neutral	0.26	neutral	2.45	deleterious	-4.76	deleterious	-5.93	high_impact	4.63	0.7	neutral	0.36	neutral	3.72	23.30	deleterious	0.01	0.35	NA	NA	0.92	disease	0.74	disease	0.8	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.02	medium_impact	2.86	high_impact	0.15	0.8	60.06	10.35	0.69	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9040	9040	C	A	MI.1094	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	514	172	H	N	Cac/Aac	-7.04	0	0	possibly_damaging	0.46	neutral	0.31	neutral	4.39	neutral	0.02	deleterious	-4.23	low_impact	1.49	0.78	neutral	0.4	neutral	3.90	23.50	deleterious	0.47	0.65	0.59	disease	0.78	disease	0.54	disease	0.74	disease	5	0.65	neutral	0.43	neutral	-3	neutral	0.63	deleterious	-0.69	medium_impact	0.1	medium_impact	0.18	medium_impact	0.43	0.9	49.56	8.68	0.23	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3392	3392	G	T	MI.10940	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	86	29	G	V	gGc/gTc	5.96	1	0	probably_damaging	1	neutral	0.59	neutral	2.46	deleterious	-3.93	deleterious	-7.72	high_impact	4.29	0.65	neutral	0.39	neutral	3.63	23.20	deleterious	0.01	0.35	NA	NA	0.91	disease	0.65	disease	0.73	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	0.36	medium_impact	2.56	high_impact	0.17	0.8	60.06	10.35	0.63	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3394	3394	T	C	MI.10941	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	88	30	Y	H	Tat/Cat	-5.52	0	0.04	benign	0.11	neutral	0.55	neutral	2.7	neutral	-0.32	deleterious	-4.4	medium_impact	2.17	0.32	damaging	0.48	neutral	1.52	13.40	neutral	0.14	0.4	NA	NA	0.83	disease	0.75	disease	0.64	disease	3	0.36	neutral	0.72	deleterious	-3	neutral	0.34	neutral	0.1	medium_impact	0.32	medium_impact	0.71	medium_impact	0.11	0.8	55.35	9.53	0.76	P	0.22	disease_causing_automatic	0	0.14	rs41460449	Pathogenic	Leber's_optic_atrophy|not_specified	24764	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:CN169374	acute leukemia platelets, leukocytes & bone marrow	.	.	0.89	T3394C	LHON / Diabetes / CPTdeficiency / high altitude adaptation	+	-	Reported / Population-dependent	28	P	N	P,N	damaging
chrM	3394	3394	T	G	MI.10942	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	88	30	Y	D	Tat/Gat	-5.52	0	0.04	probably_damaging	0.93	neutral	0.41	neutral	2.71	neutral	-0.42	deleterious	-8.85	medium_impact	3.46	0.7	neutral	0.41	neutral	3.51	23.10	deleterious	0.04	0.35	NA	NA	0.92	disease	0.77	disease	0.8	disease	6	0.93	neutral	0.24	neutral	1	deleterious	0.85	deleterious	-1.81	low_impact	0.19	medium_impact	1.83	medium_impact	0.08	0.8	55.35	9.53	0.45	N	0.93	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3394	3394	T	A	MI.10943	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	88	30	Y	N	Tat/Aat	-5.52	0	0.04	possibly_damaging	0.87	neutral	0.46	neutral	2.72	neutral	-0.65	deleterious	-7.96	high_impact	4.5	0.68	neutral	0.46	neutral	2.22	17.63	deleterious	0.08	0.35	NA	NA	0.89	disease	0.74	disease	0.78	disease	6	0.86	neutral	0.3	neutral	1	deleterious	0.78	deleterious	-1.53	low_impact	0.24	medium_impact	2.74	high_impact	0.11	0.8	55.35	9.53	0.56	P	0.85	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3395	3395	A	C	MI.10944	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	89	30	Y	S	tAt/tCt	3.67	1	0.01	possibly_damaging	0.81	neutral	0.65	neutral	2.81	neutral	0.17	deleterious	-7.95	medium_impact	2.27	0.61	neutral	0.55	neutral	1.95	15.91	deleterious	0.06	0.35	NA	NA	0.88	disease	0.65	disease	0.52	disease	0	0.78	neutral	0.42	neutral	0	NA	0.82	deleterious	-1.34	low_impact	0.43	medium_impact	0.79	medium_impact	0.16	0.8	55.35	9.53	0.48	N	0.85	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3395	3395	A	G	MI.10945	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	89	30	Y	C	tAt/tGt	3.67	1	0.01	benign	0.17	neutral	0.18	neutral	2.69	neutral	-2.68	deleterious	-7.95	high_impact	3.95	0.64	neutral	0.37	neutral	3.34	22.90	deleterious	0.04	0.35	NA	NA	0.89	disease	0.76	disease	0.79	disease	6	0.79	neutral	0.51	deleterious	-2	neutral	0.35	neutral	-0.1	medium_impact	-0.09	medium_impact	2.26	high_impact	0.04	0.8	55.35	9.53	0.62	P	0.92	polymorphism	1	0.37	.	.	.	.	.	.	.	CPD	0.74	A3395G	LHON / HCM with hearing loss	+	+	Reported	3	.	P	P	damaging
chrM	3395	3395	A	T	MI.10946	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	89	30	Y	F	tAt/tTt	3.67	1	0.01	possibly_damaging	0.77	neutral	0.7	neutral	2.73	neutral	0.77	deleterious	-3.53	medium_impact	2.63	0.62	neutral	0.42	neutral	1.64	14.09	neutral	0.2	0.45	NA	NA	0.81	disease	0.69	disease	0.71	disease	4	0.73	neutral	0.47	neutral	0	NA	0.74	deleterious	-1.24	low_impact	0.48	medium_impact	1.11	medium_impact	0.38	0.8	55.35	9.53	0.53	P	0.60	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3397	3397	A	T	MI.10947	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	91	31	M	L	Ata/Tta	-3.69	0	0.01	benign	0.23	neutral	0.46	neutral	2.81	neutral	-0.9	deleterious	-2.64	medium_impact	2.69	0.55	damaging	0.43	neutral	1.21	11.83	neutral	0.15	0.4	NA	NA	0.82	disease	0.7	disease	0.73	disease	5	0.44	neutral	0.62	deleterious	-3	neutral	0.36	neutral	-0.26	medium_impact	0.24	medium_impact	1.16	medium_impact	0.42	0.8	55.66	10.29	0.34	N	0.70	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3397	3397	A	G	MI.10948	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	91	31	M	V	Ata/Gta	-3.69	0	0.01	benign	0.32	neutral	0.41	neutral	2.85	neutral	-0.83	deleterious	-3.48	medium_impact	2.37	0.25	damaging	0.46	neutral	0.63	8.38	deleterious	0.15	0.4	NA	NA	0.83	disease	0.62	disease	0.54	disease	1	0.51	neutral	0.55	deleterious	-3	neutral	0.42	neutral	-0.44	medium_impact	0.19	medium_impact	0.88	medium_impact	0.41	0.8	55.66	10.29	0.94	P	0.84	disease_causing_automatic	0	0.12	rs199476120	Pathogenic	Alzheimer's_disease|Parkinson_disease,_late-onset	24765	MedGen:C0002395,OMIM:104300,SNOMED_CT:26929004|MedGen:C3160718,OMIM:168600,SNOMED_CT:49049000	.	.	.	.	A3397G	ADPD / Possibly LVNC-cardiomyopathy associated	+	-	Reported	10	P	P	P	damaging
chrM	3397	3397	A	C	MI.10949	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	91	31	M	L	Ata/Cta	-3.69	0	0.01	benign	0.23	neutral	0.46	neutral	2.81	neutral	-0.9	deleterious	-2.64	medium_impact	2.69	0.55	damaging	0.43	neutral	1.18	11.65	neutral	0.15	0.4	NA	NA	0.82	disease	0.7	disease	0.73	disease	5	0.44	neutral	0.62	deleterious	-3	neutral	0.36	neutral	-0.26	medium_impact	0.24	medium_impact	1.16	medium_impact	0.42	0.8	55.66	10.29	0.34	N	0.70	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9040	9040	C	T	MI.1095	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	514	172	H	Y	Cac/Tac	-7.04	0	0	benign	0	neutral	1	neutral	4.4	neutral	0.28	deleterious	-3.71	low_impact	1.72	0.87	neutral	0.41	neutral	3.71	23.30	deleterious	0.52	0.65	0.6	disease	0.8	disease	0.46	neutral	0.65	disease	3	0	neutral	1	deleterious	-6	neutral	0.29	neutral	2.09	high_impact	1.98	high_impact	0.38	medium_impact	0.42	0.9	49.56	8.68	0.2	N	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3398	3398	T	C	MI.10950	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	92	31	M	T	aTa/aCa	8.49	1	0.02	benign	0.02	neutral	0.6	neutral	2.73	neutral	-2.58	deleterious	-5.28	medium_impact	2.33	0.25	damaging	0.6	neutral	0.88	9.97	deleterious	0.05	0.35	NA	NA	0.87	disease	0.65	disease	0.66	disease	3	0.37	neutral	0.79	deleterious	-3	neutral	0.32	neutral	0.84	medium_impact	0.37	medium_impact	0.85	medium_impact	0.14	0.8	55.66	10.29	0.93	P	0.41	polymorphism	1	0.15	rs201212638	.	.	.	.	.	.	CPD	1.34	T3398C	DMDF+HCM / GDM / possibly LVNC cardiomyopathy-associated	+	-	Reported	5	N	P	N,P	damaging
chrM	3398	3398	T	A	MI.10951	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	92	31	M	K	aTa/aAa	8.49	1	0.02	possibly_damaging	0.44	neutral	0.95	neutral	2.69	deleterious	-4	deleterious	-5.33	high_impact	4.26	0.67	neutral	0.39	neutral	1.88	15.47	deleterious	0.02	0.35	NA	NA	0.93	disease	0.79	disease	0.83	disease	7	0.38	neutral	0.76	deleterious	1	deleterious	0.56	deleterious	-0.65	medium_impact	0.99	medium_impact	2.53	high_impact	0.17	0.8	55.66	10.29	0.64	P	0.96	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3399	3399	A	C	MI.10952	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	93	31	M	I	atA/atC	5.73	1	0	benign	0.32	neutral	0.27	neutral	2.85	neutral	-0.41	deleterious	-3.5	low_impact	1.7	0.58	damaging	0.59	neutral	1.52	13.43	neutral	0.16	0.45	NA	NA	0.46	neutral	0.52	disease	0.33	neutral	3	0.68	neutral	0.48	deleterious	-6	neutral	0.40	neutral	-0.44	medium_impact	0.03	medium_impact	0.3	medium_impact	0.39	0.8	55.66	10.29	0.71	P	0.83	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3399	3399	A	T	MI.10953	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	93	31	M	I	atA/atT	5.73	1	0	benign	0.32	neutral	0.27	neutral	2.85	neutral	-0.41	deleterious	-3.5	low_impact	1.7	0.58	damaging	0.59	neutral	1.55	13.56	neutral	0.16	0.45	NA	NA	0.46	neutral	0.52	disease	0.33	neutral	3	0.68	neutral	0.48	deleterious	-6	neutral	0.40	neutral	-0.44	medium_impact	0.03	medium_impact	0.3	medium_impact	0.39	0.8	55.66	10.29	0.67	P	0.83	disease_causing	1	0.11	rs386828905	.	.	.	.	.	.	.	.	A3399T	Gestational Diabetes (GDM)	+	-	Reported	1	N	P	N,P	neutral
chrM	3400	3400	C	G	MI.10954	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	94	32	Q	E	Caa/Gaa	-0.93	0.02	0	probably_damaging	1	neutral	0.33	neutral	2.33	deleterious	-3.37	deleterious	-2.69	high_impact	4.48	0.66	neutral	0.06	damaging	3.01	22.30	deleterious	0.07	0.35	0.56	disease	0.85	disease	0.73	disease	0.76	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.1	medium_impact	2.72	high_impact	0.39	0.8	59.12	10.34	0.48	N	0.93	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3400	3400	C	A	MI.10955	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	94	32	Q	K	Caa/Aaa	-0.93	0.02	0	probably_damaging	1	neutral	0.39	neutral	2.36	deleterious	-3.22	deleterious	-3.59	high_impact	4.83	0.63	neutral	0.04	damaging	3.80	23.40	deleterious	0.04	0.35	0.48	neutral	0.92	disease	0.73	disease	0.78	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.17	medium_impact	3.03	high_impact	0.25	0.8	59.12	10.34	0.69	P	0.98	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3401	3401	A	G	MI.10956	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	95	32	Q	R	cAa/cGa	7.11	1	0	probably_damaging	1	neutral	0.4	neutral	2.32	deleterious	-3.6	deleterious	-3.59	high_impact	4.48	0.63	neutral	0.04	damaging	3.25	22.80	deleterious	0.04	0.35	0.54	disease	0.9	disease	0.74	disease	0.78	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.18	medium_impact	2.72	high_impact	0.31	0.8	59.12	10.34	0.67	P	0.95	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3401	3401	A	T	MI.10957	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	95	32	Q	L	cAa/cTa	7.11	1	0	probably_damaging	1	neutral	0.7	neutral	2.27	deleterious	-4.79	deleterious	-6.3	high_impact	4.48	0.66	neutral	0.04	damaging	3.53	23.10	deleterious	0.02	0.35	0.75	disease	0.91	disease	0.66	disease	0.72	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.48	medium_impact	2.72	high_impact	0.14	0.8	59.12	10.34	0.6	P	0.99	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3401	3401	A	C	MI.10958	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	95	32	Q	P	cAa/cCa	7.11	1	0	probably_damaging	1	neutral	0.21	neutral	2.25	deleterious	-5.6	deleterious	-5.39	high_impact	4.83	0.64	neutral	0.09	damaging	3.15	22.60	deleterious	0.02	0.35	0.82	disease	0.92	disease	0.77	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.94	deleterious	-3.57	low_impact	-0.05	medium_impact	3.03	high_impact	0.20	0.8	59.12	10.34	0.79	P	0.98	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3402	3402	A	C	MI.10959	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	96	32	Q	H	caA/caC	8.49	1	0	probably_damaging	1	neutral	0.53	neutral	2.27	deleterious	-3.78	deleterious	-4.48	medium_impact	3.1	0.63	neutral	0.04	damaging	3.26	22.80	deleterious	0.04	0.35	0.48	neutral	0.84	disease	0.67	disease	0.53	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.86	deleterious	-3.57	low_impact	0.3	medium_impact	1.52	medium_impact	0.52	0.8	59.12	10.34	0.53	N	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9041	9041	A	T	MI.1096	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	515	172	H	L	cAc/cTc	5.68	1	0	benign	0.16	neutral	0.63	neutral	4.51	neutral	2.08	deleterious	-7.1	low_impact	1.28	0.82	neutral	0.36	neutral	3.90	23.50	deleterious	0.29	0.65	0.47	neutral	0.88	disease	0.54	disease	0.79	disease	6	0.25	neutral	0.74	deleterious	-6	neutral	0.49	deleterious	-0.07	medium_impact	0.42	medium_impact	0	medium_impact	0.36	0.9	49.56	8.68	0.42	N	0.96	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3402	3402	A	T	MI.10960	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	96	32	Q	H	caA/caT	8.49	1	0	probably_damaging	1	neutral	0.53	neutral	2.27	deleterious	-3.78	deleterious	-4.48	medium_impact	3.1	0.63	neutral	0.04	damaging	3.41	23.00	deleterious	0.04	0.35	0.48	neutral	0.84	disease	0.67	disease	0.53	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.86	deleterious	-3.57	low_impact	0.3	medium_impact	1.52	medium_impact	0.52	0.8	59.12	10.34	0.53	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3403	3403	C	G	MI.10961	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	97	33	L	V	Cta/Gta	1.6	0.83	0	possibly_damaging	0.74	neutral	0.64	neutral	2.78	neutral	-0.23	neutral	-2.17	medium_impact	2.32	0.83	neutral	0.54	neutral	3.27	22.80	deleterious	0.18	0.45	0.25	neutral	0.65	disease	0.3	neutral	0.48	neutral	0	0.7	neutral	0.45	neutral	0	NA	0.57	deleterious	-1.18	low_impact	0.42	medium_impact	0.84	medium_impact	0.43	0.8	53.46	9.37	0.26	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3403	3403	C	A	MI.10962	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	97	33	L	M	Cta/Ata	1.6	0.83	0	probably_damaging	0.97	neutral	0.22	neutral	2.75	neutral	-0.72	neutral	-1.32	medium_impact	2.48	0.84	neutral	0.61	neutral	3.79	23.40	deleterious	0.2	0.45	0.41	neutral	0.54	disease	0.25	neutral	0.48	neutral	0	0.98	neutral	0.13	neutral	1	deleterious	0.71	deleterious	-2.17	low_impact	-0.03	medium_impact	0.98	medium_impact	0.51	0.8	53.46	9.37	0.37	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3404	3404	T	A	MI.10963	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	98	33	L	Q	cTa/cAa	-0.47	0.13	0	probably_damaging	0.98	neutral	0.35	neutral	2.83	neutral	0.19	deleterious	-4.31	medium_impact	2.68	0.72	neutral	0.45	neutral	4.15	23.80	deleterious	0.04	0.35	0.22	neutral	0.79	disease	0.2	neutral	0.62	disease	2	0.99	deleterious	0.19	neutral	1	deleterious	0.74	deleterious	-2.34	low_impact	0.12	medium_impact	1.15	medium_impact	0.10	0.8	53.46	9.37	0.43	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3404	3404	T	C	MI.10964	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	98	33	L	P	cTa/cCa	-0.47	0.13	0	probably_damaging	0.98	neutral	0.2	neutral	2.72	neutral	-2.02	deleterious	-5.23	high_impact	3.58	0.65	neutral	0.42	neutral	3.87	23.50	deleterious	0.03	0.35	0.48	neutral	0.88	disease	0.57	disease	0.71	disease	4	0.99	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-2.34	low_impact	-0.06	medium_impact	1.94	medium_impact	0.12	0.8	53.46	9.37	0.44	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3404	3404	T	G	MI.10965	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	98	33	L	R	cTa/cGa	-0.47	0.13	0	probably_damaging	0.97	neutral	0.39	neutral	2.79	neutral	0.71	deleterious	-4.34	low_impact	1.87	0.67	neutral	0.4	neutral	4.08	23.70	deleterious	0.04	0.35	0.17	neutral	0.85	disease	0.38	neutral	0.53	disease	1	0.97	neutral	0.21	neutral	-2	neutral	0.76	deleterious	-2.17	low_impact	0.17	medium_impact	0.45	medium_impact	0.07	0.8	53.46	9.37	0.33	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3406	3406	C	G	MI.10966	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	100	34	R	G	Cgc/Ggc	-7.13	0	0	probably_damaging	1	neutral	0.4	neutral	1.63	deleterious	-7.38	deleterious	-6.31	high_impact	4.54	0.61	neutral	0.43	neutral	4.09	23.70	deleterious	0.02	0.35	0.82	disease	0.85	disease	0.81	disease	0.8	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.18	medium_impact	2.78	high_impact	0.05	0.8	59.12	10.46	0.52	N	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3406	3406	C	T	MI.10967	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	100	34	R	C	Cgc/Tgc	-7.13	0	0	probably_damaging	1	neutral	0.17	neutral	1.6	deleterious	-9.35	deleterious	-7.21	high_impact	4.88	0.6	neutral	0.25	damaging	4.89	24.90	deleterious	0.04	0.35	0.94	disease	0.92	disease	0.82	disease	0.83	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.94	deleterious	-3.57	low_impact	-0.11	medium_impact	3.07	high_impact	0.41	0.8	59.12	10.46	0.57	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3406	3406	C	A	MI.10968	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	100	34	R	S	Cgc/Agc	-7.13	0	0	probably_damaging	1	neutral	0.39	neutral	1.64	deleterious	-6.53	deleterious	-5.4	high_impact	4.88	0.58	damaging	0.46	neutral	4.44	24.20	deleterious	0.02	0.35	0.76	disease	0.92	disease	0.78	disease	0.8	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	0.17	medium_impact	3.07	high_impact	0.05	0.8	59.12	10.46	0.68	P	0.74	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3407	3407	G	C	MI.10969	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	101	34	R	P	cGc/cCc	5.5	1	0	probably_damaging	1	neutral	0.19	neutral	1.61	deleterious	-7.81	deleterious	-6.3	high_impact	4.88	0.69	neutral	0.32	neutral	4.14	23.80	deleterious	0.02	0.35	0.87	disease	0.93	disease	0.81	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.94	deleterious	-3.57	low_impact	-0.08	medium_impact	3.07	high_impact	0.04	0.8	59.12	10.46	0.74	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9041	9041	A	C	MI.1097	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	515	172	H	P	cAc/cCc	5.68	1	0	possibly_damaging	0.78	neutral	0.2	neutral	4.38	neutral	-0.85	deleterious	-6.34	medium_impact	2.87	0.73	neutral	0.27	damaging	3.36	22.90	deleterious	0.27	0.65	0.75	disease	0.94	disease	0.72	disease	0.87	disease	7	0.87	neutral	0.21	neutral	0	NA	0.83	deleterious	-1.28	low_impact	-0.05	medium_impact	1.36	medium_impact	0.41	0.9	49.56	8.68	0.51	N	1.00	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3407	3407	G	A	MI.10970	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	101	34	R	H	cGc/cAc	5.5	1	0	probably_damaging	1	neutral	0.52	neutral	1.62	deleterious	-7.08	deleterious	-4.5	high_impact	4.88	0.49	damaging	0.25	damaging	4.35	24.10	deleterious	0.05	0.35	0.8	disease	0.89	disease	0.78	disease	0.81	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	0.29	medium_impact	3.07	high_impact	0.41	0.8	59.12	10.46	0.8	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	G3407A	HCM / Muscle involvement	+	-	Conflicting reports	3	.	N	N	damaging
chrM	3407	3407	G	T	MI.10971	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	101	34	R	L	cGc/cTc	5.5	1	0	probably_damaging	1	neutral	0.74	neutral	1.63	deleterious	-6.75	deleterious	-6.31	high_impact	4.88	0.59	damaging	0.35	neutral	4.20	23.90	deleterious	0.02	0.35	0.8	disease	0.94	disease	0.78	disease	0.87	disease	7	1	deleterious	0.37	neutral	2	deleterious	0.93	deleterious	-3.57	low_impact	0.53	medium_impact	3.07	high_impact	0.02	0.8	59.12	10.46	0.76	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3409	3409	A	G	MI.10972	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	103	35	K	E	Aaa/Gaa	-1.85	0	0	probably_damaging	1	neutral	0.27	neutral	2.66	neutral	-1.53	deleterious	-3.61	high_impact	4.1	0.68	neutral	0.06	damaging	3.92	23.50	deleterious	0.11	0.4	0.34	neutral	0.9	disease	0.64	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.03	medium_impact	2.39	high_impact	0.44	0.8	59.43	10.53	0.42	N	0.92	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3409	3409	A	C	MI.10973	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	103	35	K	Q	Aaa/Caa	-1.85	0	0	probably_damaging	1	neutral	0.3	neutral	2.64	neutral	-0.7	deleterious	-3.61	high_impact	3.67	0.6	neutral	0.07	damaging	3.37	22.90	deleterious	0.27	0.45	0.39	neutral	0.86	disease	0.55	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.07	medium_impact	2.02	high_impact	0.40	0.8	59.43	10.53	0.35	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3410	3410	A	C	MI.10974	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	104	35	K	T	aAa/aCa	8.49	1	0	probably_damaging	1	neutral	0.39	neutral	2.66	neutral	-0.67	deleterious	-5.41	high_impact	3.96	0.59	damaging	0.07	damaging	3.54	23.10	deleterious	0.06	0.35	0.3	neutral	0.91	disease	0.63	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.17	medium_impact	2.27	high_impact	0.15	0.8	59.43	10.53	0.59	P	0.82	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3410	3410	A	T	MI.10975	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	104	35	K	M	aAa/aTa	8.49	1	0	probably_damaging	1	neutral	0.22	neutral	2.62	neutral	-0.41	deleterious	-5.41	medium_impact	3.37	0.65	neutral	0.05	damaging	3.87	23.50	deleterious	0.06	0.35	0.37	neutral	0.89	disease	0.56	disease	0.67	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	-0.03	medium_impact	1.76	medium_impact	0.15	0.8	59.43	10.53	0.58	P	0.50	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3411	3411	A	C	MI.10976	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	105	35	K	N	aaA/aaC	8.49	1	0	probably_damaging	1	neutral	0.31	neutral	2.63	neutral	-1.89	deleterious	-4.51	high_impact	4.3	0.63	neutral	0.06	damaging	3.76	23.30	deleterious	0.22	0.45	0.42	neutral	0.88	disease	0.63	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.08	medium_impact	2.57	high_impact	0.37	0.8	59.43	10.53	0.66	P	0.84	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3411	3411	A	T	MI.10977	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	105	35	K	N	aaA/aaT	8.49	1	0	probably_damaging	1	neutral	0.31	neutral	2.63	neutral	-1.89	deleterious	-4.51	high_impact	4.3	0.63	neutral	0.06	damaging	3.89	23.50	deleterious	0.22	0.45	0.42	neutral	0.88	disease	0.63	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.08	medium_impact	2.57	high_impact	0.37	0.8	59.43	10.53	0.66	P	0.84	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3412	3412	G	A	MI.10978	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	106	36	G	S	Ggc/Agc	-0.01	0.91	0	probably_damaging	1	neutral	0.4	neutral	1.12	deleterious	-5.95	deleterious	-5.42	high_impact	4.2	0.24	damaging	0.06	damaging	4.16	23.80	deleterious	0.02	0.35	0.87	disease	0.92	disease	0.69	disease	0.78	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	0.18	medium_impact	2.48	high_impact	0.58	0.8	60.38	10.43	0.88	P	0.99	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3412	3412	G	T	MI.10979	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	106	36	G	C	Ggc/Tgc	-0.01	0.91	0	probably_damaging	1	neutral	0.17	neutral	1.08	deleterious	-8.53	deleterious	-8.13	high_impact	4.89	0.42	damaging	0.03	damaging	4.02	23.60	deleterious	0.02	0.35	0.96	disease	0.95	disease	0.73	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.94	deleterious	-3.57	low_impact	-0.11	medium_impact	3.08	high_impact	0.20	0.8	60.38	10.43	0.59	P	0.98	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9041	9041	A	G	MI.1098	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	515	172	H	R	cAc/cGc	5.68	1	0	benign	0.38	neutral	0.34	neutral	4.4	neutral	0.18	deleterious	-4.55	medium_impact	2.52	0.83	neutral	0.33	neutral	3.05	22.40	deleterious	0.49	0.65	0.57	disease	0.87	disease	0.58	disease	0.79	disease	6	0.6	neutral	0.48	deleterious	-3	neutral	0.66	deleterious	-0.55	medium_impact	0.13	medium_impact	1.06	medium_impact	0.35	0.9	49.56	8.68	0.47	N	1.00	disease_causing	1	0.08	rs879244322	not_provided	not_provided	434701	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3412	3412	G	C	MI.10980	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	106	36	G	R	Ggc/Cgc	-0.01	0.91	0	probably_damaging	1	neutral	0.37	neutral	1.09	deleterious	-8.09	deleterious	-7.22	high_impact	4.89	0.46	damaging	0.04	damaging	3.85	23.40	deleterious	0.01	0.35	0.94	disease	0.95	disease	0.77	disease	0.85	disease	7	1	deleterious	0.19	neutral	2	deleterious	0.95	deleterious	-3.57	low_impact	0.15	medium_impact	3.08	high_impact	0.57	0.8	60.38	10.43	0.62	P	0.99	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3413	3413	G	C	MI.10981	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	107	36	G	A	gGc/gCc	8.95	1	0	probably_damaging	1	neutral	0.49	neutral	1.13	deleterious	-5.38	deleterious	-5.42	high_impact	4.09	0.3	damaging	0.07	damaging	2.99	22.20	deleterious	0.02	0.35	0.84	disease	0.89	disease	0.69	disease	0.75	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.27	medium_impact	2.38	high_impact	0.30	0.8	60.38	10.43	0.75	P	0.76	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3413	3413	G	A	MI.10982	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	107	36	G	D	gGc/gAc	8.95	1	0	probably_damaging	1	neutral	0.2	neutral	1.1	deleterious	-8.01	deleterious	-6.32	high_impact	4.89	0.41	damaging	0.04	damaging	3.81	23.40	deleterious	0.01	0.35	0.92	disease	0.95	disease	0.78	disease	0.86	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	-0.06	medium_impact	3.08	high_impact	0.17	0.8	60.38	10.43	0.79	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3413	3413	G	T	MI.10983	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	107	36	G	V	gGc/gTc	8.95	1	0	probably_damaging	1	neutral	0.49	neutral	1.09	deleterious	-7.26	deleterious	-8.13	high_impact	4.89	0.36	damaging	0.05	damaging	3.66	23.20	deleterious	0.01	0.35	0.94	disease	0.96	disease	0.71	disease	0.82	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.94	deleterious	-3.57	low_impact	0.27	medium_impact	3.08	high_impact	0.16	0.8	60.38	10.43	0.7	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3415	3415	C	G	MI.10984	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	109	37	P	A	Ccc/Gcc	-13.11	0	0	probably_damaging	1	neutral	0.52	neutral	1.22	deleterious	-5.75	deleterious	-7.16	high_impact	4.2	0.71	neutral	0.13	damaging	2.92	21.90	deleterious	0.06	0.35	0.42	neutral	0.8	disease	0.65	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.29	medium_impact	2.48	high_impact	0.68	0.85	59.43	10.72	0.3	N	0.78	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3415	3415	C	A	MI.10985	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	109	37	P	T	Ccc/Acc	-13.11	0	0	probably_damaging	1	neutral	0.41	neutral	1.19	deleterious	-6.45	deleterious	-7.16	high_impact	4.54	0.66	neutral	0.09	damaging	3.55	23.10	deleterious	0.04	0.35	0.67	disease	0.87	disease	0.57	disease	0.7	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.19	medium_impact	2.78	high_impact	0.39	0.8	59.43	10.72	0.36	N	0.91	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3415	3415	C	T	MI.10986	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	109	37	P	S	Ccc/Tcc	-13.11	0	0	probably_damaging	1	neutral	0.42	neutral	1.21	deleterious	-6.02	deleterious	-7.16	high_impact	4.54	0.73	neutral	0.12	damaging	3.81	23.40	deleterious	0.04	0.35	0.59	disease	0.86	disease	0.64	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.2	medium_impact	2.78	high_impact	0.12	0.8	59.43	10.72	0.41	N	0.74	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3416	3416	C	T	MI.10987	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	110	37	P	L	cCc/cTc	7.11	1	0	probably_damaging	1	neutral	0.67	neutral	1.19	deleterious	-6.82	deleterious	-8.96	high_impact	4.54	0.78	neutral	0.1	damaging	4.31	24.00	deleterious	0.03	0.35	0.82	disease	0.9	disease	0.63	disease	0.73	disease	5	1	deleterious	0.34	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.45	medium_impact	2.78	high_impact	0.55	0.8	59.43	10.72	0.56	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3416	3416	C	G	MI.10988	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	110	37	P	R	cCc/cGc	7.11	1	0	probably_damaging	1	neutral	0.39	neutral	1.18	deleterious	-6.98	deleterious	-8.06	high_impact	4.54	0.74	neutral	0.1	damaging	3.50	23.10	deleterious	0.02	0.35	0.84	disease	0.91	disease	0.71	disease	0.77	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.17	medium_impact	2.78	high_impact	0.17	0.8	59.43	10.72	0.62	P	0.71	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3416	3416	C	A	MI.10989	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	110	37	P	H	cCc/cAc	7.11	1	0	probably_damaging	1	neutral	0.53	neutral	1.17	deleterious	-8.08	deleterious	-8.06	high_impact	4.54	0.69	neutral	0.1	damaging	3.94	23.50	deleterious	0.03	0.35	0.91	disease	0.89	disease	0.71	disease	0.81	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.3	medium_impact	2.78	high_impact	0.19	0.8	59.43	10.72	0.61	P	0.69	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9042	9042	C	G	MI.1099	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	516	172	H	Q	caC/caG	7.07	1	0	possibly_damaging	0.6	neutral	0.52	neutral	4.42	neutral	0.93	deleterious	-3.47	neutral_impact	-0.36	0.68	neutral	0.6	neutral	0.96	10.45	neutral	0.49	0.65	0.44	neutral	0.21	neutral	0.36	neutral	0.36	neutral	3	0.57	neutral	0.46	neutral	-3	neutral	0.55	deleterious	-0.92	medium_impact	0.31	medium_impact	-1.41	low_impact	0.44	0.9	49.56	8.68	0.5	P	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3418	3418	A	G	MI.10990	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	112	38	N	D	Aac/Gac	-4.15	0	0	probably_damaging	1	neutral	0.32	neutral	2.63	neutral	-1.27	deleterious	-4.47	medium_impact	3.49	0.72	neutral	0.11	damaging	3.75	23.30	deleterious	0.32	0.5	0.23	neutral	0.8	disease	0.65	disease	0.68	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.09	medium_impact	1.86	medium_impact	0.19	0.8	59.75	10.53	0.4	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	A3418G	AMegL	+	-	Reported	1	.	P	P	damaging
chrM	3418	3418	A	C	MI.10991	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	112	38	N	H	Aac/Cac	-4.15	0	0	probably_damaging	1	neutral	0.55	neutral	2.51	deleterious	-3.4	deleterious	-4.47	high_impact	4.81	0.68	neutral	0.08	damaging	2.91	21.90	deleterious	0.17	0.45	0.33	neutral	0.83	disease	0.63	disease	0.69	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.32	medium_impact	3.01	high_impact	0.19	0.8	59.75	10.53	0.58	P	0.97	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3418	3418	A	T	MI.10992	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	112	38	N	Y	Aac/Tac	-4.15	0	0	probably_damaging	1	neutral	1	neutral	2.5	deleterious	-4.31	deleterious	-7.16	high_impact	3.71	0.7	neutral	0.07	damaging	3.65	23.20	deleterious	0.06	0.35	0.52	disease	0.9	disease	0.69	disease	0.74	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.57	low_impact	1.96	high_impact	2.05	high_impact	0.16	0.8	59.75	10.53	0.27	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3419	3419	A	T	MI.10993	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	113	38	N	I	aAc/aTc	8.49	1	0	probably_damaging	1	neutral	0.45	neutral	2.5	deleterious	-3.99	deleterious	-8.05	high_impact	4.81	0.75	neutral	0.14	damaging	3.89	23.50	deleterious	0.06	0.35	0.45	neutral	0.89	disease	0.65	disease	0.71	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.23	medium_impact	3.01	high_impact	0.10	0.8	59.75	10.53	0.72	P	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3419	3419	A	G	MI.10994	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	113	38	N	S	aAc/aGc	8.49	1	0	probably_damaging	1	neutral	0.53	neutral	2.57	neutral	-1.96	deleterious	-4.46	high_impact	3.71	0.66	neutral	0.11	damaging	3.04	22.40	deleterious	0.34	0.5	0.2	neutral	0.8	disease	0.57	disease	0.62	disease	2	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.3	medium_impact	2.05	high_impact	0.18	0.8	59.75	10.53	0.56	P	0.90	polymorphism	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3419	3419	A	C	MI.10995	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	113	38	N	T	aAc/aCc	8.49	1	0	probably_damaging	1	neutral	0.49	neutral	2.57	neutral	-2.05	deleterious	-5.36	medium_impact	3.34	0.64	neutral	0.1	damaging	3.34	22.90	deleterious	0.17	0.45	0.2	neutral	0.87	disease	0.58	disease	0.69	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.27	medium_impact	1.73	medium_impact	0.20	0.8	59.75	10.53	0.53	P	0.96	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3420	3420	C	A	MI.10996	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	114	38	N	K	aaC/aaA	8.49	1	0	probably_damaging	1	neutral	0.5	neutral	2.59	neutral	-1.69	deleterious	-5.37	high_impact	4	0.75	neutral	0.1	damaging	4.37	24.10	deleterious	0.2	0.45	0.18	neutral	0.87	disease	0.66	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.28	medium_impact	2.31	high_impact	0.27	0.8	59.75	10.53	0.59	P	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3420	3420	C	G	MI.10997	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	114	38	N	K	aaC/aaG	8.49	1	0	probably_damaging	1	neutral	0.5	neutral	2.59	neutral	-1.69	deleterious	-5.37	high_impact	4	0.75	neutral	0.1	damaging	3.85	23.40	deleterious	0.2	0.45	0.18	neutral	0.87	disease	0.66	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.28	medium_impact	2.31	high_impact	0.27	0.8	59.75	10.53	0.59	P	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3421	3421	G	A	MI.10998	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	115	39	V	I	Gtt/Att	-2.31	0	0.02	benign	0	neutral	0.49	neutral	2.76	neutral	-0.81	neutral	0.19	neutral_impact	-0.71	0.74	neutral	0.91	neutral	-1.07	0.01	neutral	0.37	0.5	0.17	neutral	0.05	neutral	0.14	neutral	0.22	neutral	6	0.51	neutral	0.75	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.27	medium_impact	-1.81	low_impact	0.74	0.85	52.52	8.44	0.48	N	0.00	polymorphism	1	0.01	.	.	.	.	.	pancreatic cancer cell line	COSM1155614	CPD	53.41	G3421A	MIDD	+	-	Reported	1	.	P	P	neutral
chrM	3421	3421	G	C	MI.10999	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	115	39	V	L	Gtt/Ctt	-2.31	0	0.02	benign	0.02	neutral	0.8	neutral	2.74	neutral	-0.97	neutral	-1.46	neutral_impact	0.77	0.75	neutral	0.61	neutral	1.46	13.10	neutral	0.27	0.45	0.19	neutral	0.51	disease	0.25	neutral	0.44	neutral	1	0.15	neutral	0.89	deleterious	-6	neutral	0.15	neutral	0.84	medium_impact	0.61	medium_impact	-0.52	medium_impact	0.46	0.8	52.52	8.44	0.3	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8531	8531	A	G	MI.11	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	5	2	N	S	aAc/aGc	6.84	1	0	probably_damaging	0.95	neutral	0.13	neutral	4.68	neutral	-0.02	deleterious	-2.52	low_impact	1.9	0.91	neutral	0.62	neutral	3.55	23.10	deleterious	0.78	0.8	0.41	neutral	0.26	neutral	0.1	neutral	0.45	neutral	1	0.98	neutral	0.09	neutral	-2	neutral	0.64	deleterious	-1.97	low_impact	-0.18	medium_impact	0.53	medium_impact	0.16	0.9	41.59	7.23	0.64	P	0.82	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8576	8576	T	A	MI.110	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	50	17	L	Q	cTa/cAa	-0.57	0	0	probably_damaging	1	deleterious	0.02	neutral	4.41	deleterious	-4.16	deleterious	-4.16	medium_impact	2.42	0.87	neutral	0.71	neutral	2.76	21.10	deleterious	0.19	0.65	0.89	disease	0.71	disease	0.62	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-0.66	medium_impact	0.98	medium_impact	0.73	0.9	28.76	21.22	0.37	N	0.36	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9042	9042	C	A	MI.1100	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	516	172	H	Q	caC/caA	7.07	1	0	possibly_damaging	0.6	neutral	0.52	neutral	4.42	neutral	0.93	deleterious	-3.47	neutral_impact	-0.36	0.68	neutral	0.6	neutral	1.30	12.28	neutral	0.49	0.65	0.44	neutral	0.21	neutral	0.36	neutral	0.36	neutral	3	0.57	neutral	0.46	neutral	-3	neutral	0.55	deleterious	-0.92	medium_impact	0.31	medium_impact	-1.41	low_impact	0.44	0.9	49.56	8.68	0.5	P	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3421	3421	G	T	MI.11000	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	115	39	V	F	Gtt/Ttt	-2.31	0	0.02	benign	0.23	neutral	0.7	neutral	2.67	neutral	-2.16	deleterious	-3.24	low_impact	1.84	0.72	neutral	0.48	neutral	1.85	15.27	deleterious	0.06	0.35	0.35	neutral	0.78	disease	0.55	disease	0.72	disease	4	0.19	neutral	0.74	deleterious	-6	neutral	0.37	neutral	-0.26	medium_impact	0.48	medium_impact	0.42	medium_impact	0.28	0.8	52.52	8.44	0.26	N	0.56	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3422	3422	T	C	MI.11001	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	116	39	V	A	gTt/gCt	-0.24	0	0	benign	0.1	neutral	0.79	neutral	2.71	neutral	-1.03	deleterious	-3.4	low_impact	1.53	0.77	neutral	0.63	neutral	1.52	13.44	neutral	0.21	0.45	0.16	neutral	0.54	disease	0.43	neutral	0.49	neutral	0	0.1	neutral	0.85	deleterious	-6	neutral	0.19	neutral	0.15	medium_impact	0.6	medium_impact	0.15	medium_impact	0.26	0.8	52.52	8.44	0.23	N	0.69	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3422	3422	T	G	MI.11002	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	116	39	V	G	gTt/gGt	-0.24	0	0	benign	0.29	neutral	0.5	neutral	2.64	neutral	-2.58	deleterious	-6.06	medium_impact	2.82	0.69	neutral	0.45	neutral	1.90	15.58	deleterious	0.06	0.35	0.37	neutral	0.62	disease	0.55	disease	0.68	disease	4	0.4	neutral	0.61	deleterious	-3	neutral	0.29	neutral	-0.39	medium_impact	0.28	medium_impact	1.27	medium_impact	0.12	0.8	52.52	8.44	0.31	N	0.91	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3422	3422	T	A	MI.11003	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	116	39	V	D	gTt/gAt	-0.24	0	0	benign	0.36	neutral	0.44	neutral	2.64	neutral	-2.18	deleterious	-5.52	medium_impact	2.82	0.73	neutral	0.41	neutral	2.56	19.87	deleterious	0.04	0.35	0.35	neutral	0.82	disease	0.6	disease	0.74	disease	5	0.49	neutral	0.54	deleterious	-3	neutral	0.43	deleterious	-0.52	medium_impact	0.22	medium_impact	1.27	medium_impact	0.05	0.8	52.52	8.44	0.29	N	0.92	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3424	3424	G	C	MI.11004	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	118	40	V	L	Gta/Cta	-8.05	0	0	possibly_damaging	0.52	neutral	0.26	neutral	2.42	neutral	-2.23	neutral	-2.46	medium_impact	3	0.76	neutral	0.06	damaging	3.40	23.00	deleterious	0.15	0.4	0.21	neutral	0.69	disease	0.6	disease	0.48	neutral	0	0.72	neutral	0.37	neutral	0	NA	0.47	deleterious	-0.78	medium_impact	0.02	medium_impact	1.43	medium_impact	0.48	0.8	57.86	8.72	0.32	N	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3424	3424	G	T	MI.11005	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	118	40	V	L	Gta/Tta	-8.05	0	0	possibly_damaging	0.52	neutral	0.26	neutral	2.42	neutral	-2.23	neutral	-2.46	medium_impact	3	0.76	neutral	0.06	damaging	3.56	23.10	deleterious	0.15	0.4	0.21	neutral	0.69	disease	0.6	disease	0.48	neutral	0	0.72	neutral	0.37	neutral	0	NA	0.47	deleterious	-0.78	medium_impact	0.02	medium_impact	1.43	medium_impact	0.48	0.8	57.86	8.72	0.32	N	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3424	3424	G	A	MI.11006	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	118	40	V	M	Gta/Ata	-8.05	0	0	probably_damaging	0.96	neutral	0.11	neutral	2.33	deleterious	-3.82	deleterious	-2.57	high_impact	3.64	0.79	neutral	0.11	damaging	3.59	23.20	deleterious	0.1	0.4	0.39	neutral	0.76	disease	0.73	disease	0.7	disease	4	0.98	deleterious	0.08	neutral	2	deleterious	0.74	deleterious	-2.05	low_impact	-0.23	medium_impact	1.99	medium_impact	0.57	0.8	57.86	8.72	0.35	N	0.75	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3425	3425	T	C	MI.11007	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	119	40	V	A	gTa/gCa	4.13	1	0	possibly_damaging	0.74	neutral	0.67	neutral	2.44	neutral	-1.93	deleterious	-3.55	medium_impact	3.08	0.75	neutral	0.12	damaging	3.42	23.00	deleterious	0.09	0.35	0.22	neutral	0.72	disease	0.71	disease	0.7	disease	4	0.69	neutral	0.47	neutral	0	NA	0.67	deleterious	-1.18	low_impact	0.45	medium_impact	1.5	medium_impact	0.17	0.8	57.86	8.72	0.52	N	0.89	polymorphism	1	0.12	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3425	3425	T	A	MI.11008	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	119	40	V	E	gTa/gAa	4.13	1	0	probably_damaging	0.98	neutral	0.88	neutral	2.33	deleterious	-4.06	deleterious	-5.36	high_impact	4.75	0.81	neutral	0.12	damaging	4.50	24.30	deleterious	0.02	0.35	0.44	neutral	0.87	disease	0.81	disease	0.81	disease	6	0.98	neutral	0.45	neutral	2	deleterious	0.83	deleterious	-2.34	low_impact	0.76	medium_impact	2.96	high_impact	0.08	0.8	57.86	8.72	0.71	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3425	3425	T	G	MI.11009	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	119	40	V	G	gTa/gGa	4.13	1	0	probably_damaging	0.97	neutral	0.5	neutral	2.32	deleterious	-4.24	deleterious	-6.24	high_impact	4.05	0.78	neutral	0.1	damaging	3.73	23.30	deleterious	0.03	0.35	0.53	disease	0.76	disease	0.73	disease	0.73	disease	5	0.97	neutral	0.27	neutral	2	deleterious	0.79	deleterious	-2.17	low_impact	0.28	medium_impact	2.35	high_impact	0.14	0.8	57.86	8.72	0.52	N	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9043	9043	C	A	MI.1101	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	517	173	L	M	Cta/Ata	-1.26	0	0	probably_damaging	1	deleterious	0.04	neutral	3.7	neutral	-2.43	neutral	-1.79	medium_impact	3	0.73	neutral	0.18	damaging	3.90	23.50	deleterious	0.24	0.65	0.79	disease	0.53	disease	0.4	neutral	0.57	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.75	deleterious	-3.6	low_impact	-0.49	medium_impact	1.47	medium_impact	0.57	0.9	48.67	8.82	0.36	N	0.96	disease_causing	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3427	3427	G	T	MI.11010	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	121	41	G	C	Ggc/Tgc	-7.13	0	0	probably_damaging	1	neutral	0.18	neutral	2.12	deleterious	-5.53	deleterious	-8.02	high_impact	4.8	0.48	damaging	0.01	damaging	3.99	23.60	deleterious	0.05	0.35	0.51	disease	0.94	disease	0.75	disease	0.87	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.09	medium_impact	3	high_impact	0.16	0.8	59.75	10.46	0.55	P	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3427	3427	G	C	MI.11011	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	121	41	G	R	Ggc/Cgc	-7.13	0	0	probably_damaging	1	neutral	0.52	neutral	2.14	deleterious	-4.67	deleterious	-7.12	high_impact	4.46	0.49	damaging	0.01	damaging	3.80	23.40	deleterious	0.05	0.35	0.77	disease	0.93	disease	0.83	disease	0.87	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.93	deleterious	-3.57	low_impact	0.29	medium_impact	2.71	high_impact	0.59	0.8	59.75	10.46	0.51	N	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3427	3427	G	A	MI.11012	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	121	41	G	S	Ggc/Agc	-7.13	0	0	probably_damaging	1	neutral	0.5	neutral	2.26	neutral	-2.5	deleterious	-5.33	medium_impact	2.82	0.44	damaging	0.05	damaging	4.07	23.70	deleterious	0.08	0.35	0.44	neutral	0.9	disease	0.64	disease	0.67	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.87	deleterious	-3.57	low_impact	0.28	medium_impact	1.27	medium_impact	0.49	0.8	59.75	10.46	0.39	N	0.99	polymorphism	1	0.16	.	.	.	.	.	.	COSM6716710	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3428	3428	G	A	MI.11013	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	122	41	G	D	gGc/gAc	8.95	1	0	probably_damaging	1	neutral	0.27	neutral	2.15	deleterious	-4.24	deleterious	-6.24	high_impact	4.46	0.47	damaging	0.01	damaging	3.81	23.40	deleterious	0.05	0.35	0.79	disease	0.93	disease	0.83	disease	0.87	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.03	medium_impact	2.71	high_impact	0.18	0.8	59.75	10.46	0.73	P	1.00	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3428	3428	G	C	MI.11014	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	122	41	G	A	gGc/gCc	8.95	1	0	probably_damaging	1	neutral	0.58	neutral	2.25	neutral	-2.58	deleterious	-5.31	high_impact	3.76	0.48	damaging	0.07	damaging	3.01	22.30	deleterious	0.09	0.35	0.39	neutral	0.86	disease	0.64	disease	0.71	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.35	medium_impact	2.1	high_impact	0.41	0.8	59.75	10.46	0.6	P	0.76	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3428	3428	G	T	MI.11015	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	122	41	G	V	gGc/gTc	8.95	1	0	probably_damaging	1	neutral	0.57	neutral	2.15	deleterious	-4.19	deleterious	-8.01	high_impact	4	0.43	damaging	0.02	damaging	3.65	23.20	deleterious	0.05	0.35	0.63	disease	0.94	disease	0.74	disease	0.86	disease	7	1	deleterious	0.29	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.34	medium_impact	2.31	high_impact	0.20	0.8	59.75	10.46	0.67	P	1.00	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3430	3430	C	T	MI.11016	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	124	42	P	S	Ccc/Tcc	-20	0	0	probably_damaging	1	neutral	0.4	neutral	2.73	neutral	-2.77	deleterious	-7.1	medium_impact	3.5	0.72	neutral	0.12	damaging	3.82	23.40	deleterious	0.22	0.45	0.19	neutral	0.8	disease	0.45	neutral	0.62	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.18	medium_impact	1.87	medium_impact	0.12	0.8	60.06	10.23	0.32	N	0.74	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3430	3430	C	A	MI.11017	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	124	42	P	T	Ccc/Acc	-20	0	0	probably_damaging	1	neutral	0.39	neutral	2.73	neutral	-2.88	deleterious	-7.11	high_impact	3.75	0.75	neutral	0.12	damaging	3.56	23.10	deleterious	0.11	0.4	0.21	neutral	0.78	disease	0.45	neutral	0.61	disease	2	1	deleterious	0.2	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.17	medium_impact	2.09	high_impact	0.54	0.8	60.06	10.23	0.31	N	0.91	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3430	3430	C	G	MI.11018	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	124	42	P	A	Ccc/Gcc	-20	0	0	probably_damaging	1	neutral	0.51	neutral	2.77	neutral	-2.31	deleterious	-7.11	high_impact	3.61	0.76	neutral	0.15	damaging	2.91	21.90	deleterious	0.16	0.45	0.18	neutral	0.69	disease	0.46	neutral	0.49	neutral	0	1	deleterious	0.26	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	0.29	medium_impact	1.96	medium_impact	0.62	0.8	60.06	10.23	0.29	N	0.78	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3431	3431	C	G	MI.11019	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	125	42	P	R	cCc/cGc	3.44	0.99	0	probably_damaging	1	neutral	0.35	neutral	2.69	neutral	-2.94	deleterious	-8.01	medium_impact	3.4	0.78	neutral	0.1	damaging	3.54	23.10	deleterious	0.04	0.35	0.25	neutral	0.87	disease	0.64	disease	0.71	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	0.12	medium_impact	1.78	medium_impact	0.32	0.8	60.06	10.23	0.4	N	0.71	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9043	9043	C	G	MI.1102	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	517	173	L	V	Cta/Gta	-1.26	0	0	probably_damaging	0.99	deleterious	0.03	neutral	3.67	neutral	-2.62	deleterious	-2.68	medium_impact	2.4	0.47	damaging	0.14	damaging	3.46	23.00	deleterious	0.22	0.65	0.41	neutral	0.6	disease	0.61	disease	0.58	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-2.65	low_impact	-0.56	medium_impact	0.96	medium_impact	0.64	0.9	48.67	8.82	0.31	N	0.87	disease_causing	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3431	3431	C	A	MI.11020	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	125	42	P	H	cCc/cAc	3.44	0.99	0	probably_damaging	1	neutral	0.54	neutral	2.67	deleterious	-4.32	deleterious	-8.01	high_impact	4.3	0.71	neutral	0.1	damaging	3.97	23.60	deleterious	0.07	0.35	0.4	neutral	0.83	disease	0.59	disease	0.67	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.31	medium_impact	2.57	high_impact	0.30	0.8	60.06	10.23	0.47	N	0.69	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3431	3431	C	T	MI.11021	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	125	42	P	L	cCc/cTc	3.44	0.99	0	probably_damaging	1	neutral	0.66	neutral	2.8	neutral	-2.41	deleterious	-8.9	medium_impact	2.1	0.7	neutral	0.08	damaging	4.34	24.00	deleterious	0.13	0.4	0.12	neutral	0.79	disease	0.32	neutral	0.49	neutral	0	1	deleterious	0.33	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.44	medium_impact	0.65	medium_impact	0.71	0.85	60.06	10.23	0.34	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3433	3433	T	G	MI.11022	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	127	43	Y	D	Tac/Gac	-11.73	0	0	benign	0.01	neutral	0.2	neutral	2.74	neutral	-1.79	deleterious	-7.07	medium_impact	3.27	0.79	neutral	0.4	neutral	3.61	23.20	deleterious	0.05	0.35	0.43	neutral	0.81	disease	0.73	disease	0.76	disease	5	0.8	neutral	0.6	deleterious	-3	neutral	0.25	neutral	1.12	medium_impact	-0.06	medium_impact	1.67	medium_impact	0.15	0.8	23.9	10.39	0.4	N	0.99	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3433	3433	T	C	MI.11023	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	127	43	Y	H	Tac/Cac	-11.73	0	0	benign	0.01	neutral	0.53	neutral	2.75	neutral	-0.78	deleterious	-3.48	low_impact	1.43	0.87	neutral	0.88	neutral	2.16	17.22	deleterious	0.15	0.4	0.23	neutral	0.63	disease	0.4	neutral	0.47	neutral	1	0.45	neutral	0.76	deleterious	-6	neutral	0.19	neutral	1.12	medium_impact	0.3	medium_impact	0.06	medium_impact	0.19	0.8	23.9	10.39	0.34	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3433	3433	T	A	MI.11024	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	127	43	Y	N	Tac/Aac	-11.73	0	0	benign	0.01	neutral	0.34	neutral	2.76	neutral	-1.32	deleterious	-6.27	medium_impact	2.17	0.81	neutral	0.65	neutral	3.62	23.20	deleterious	0.08	0.35	0.33	neutral	0.76	disease	0.55	disease	0.65	disease	3	0.65	neutral	0.67	deleterious	-3	neutral	0.22	neutral	1.12	medium_impact	0.11	medium_impact	0.71	medium_impact	0.14	0.8	23.9	10.39	0.36	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3434	3434	A	C	MI.11025	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	128	43	Y	S	tAc/tCc	0.68	0	0.01	benign	0.18	neutral	0.4	neutral	2.81	neutral	-0.43	deleterious	-6.08	low_impact	1.54	0.74	neutral	0.52	neutral	1.87	15.39	deleterious	0.08	0.35	0.17	neutral	0.73	disease	0.55	disease	0.63	disease	3	0.52	neutral	0.61	deleterious	-6	neutral	0.26	neutral	-0.13	medium_impact	0.18	medium_impact	0.16	medium_impact	0.18	0.8	23.9	10.39	0.3	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3434	3434	A	T	MI.11026	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	128	43	Y	F	tAc/tTc	0.68	0	0.01	benign	0.01	neutral	0.7	neutral	2.81	neutral	1.34	neutral	-2.32	neutral_impact	-0.44	0.87	neutral	0.9	neutral	0.44	6.93	deleterious	0.26	0.45	0.11	neutral	0.37	neutral	0.26	neutral	0.43	neutral	1	0.28	neutral	0.85	deleterious	-6	neutral	0.15	neutral	1.12	medium_impact	0.48	medium_impact	-1.57	low_impact	0.33	0.8	23.9	10.39	0.34	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3434	3434	A	G	MI.11027	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	128	43	Y	C	tAc/tGc	0.68	0	0.01	benign	0.02	neutral	0.17	neutral	2.74	neutral	-2.26	deleterious	-6.16	low_impact	1.89	0.85	neutral	0.8	neutral	1.51	13.39	neutral	0.04	0.35	0.37	neutral	0.81	disease	0.37	neutral	0.54	disease	1	0.82	neutral	0.58	deleterious	-6	neutral	0.22	neutral	0.84	medium_impact	-0.11	medium_impact	0.46	medium_impact	0.11	0.8	23.9	10.39	0.38	N	0.60	polymorphism	1	0.10	rs202123618	.	.	.	.	prostate tumor	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3436	3436	G	T	MI.11028	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	130	44	G	W	Ggg/Tgg	-5.3	0	0	probably_damaging	1	neutral	0.18	neutral	1.07	deleterious	-9.79	deleterious	-7.23	high_impact	4.58	0.68	neutral	0.06	damaging	4.34	24.00	deleterious	0.02	0.35	0.96	disease	0.92	disease	0.8	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	-0.09	medium_impact	2.81	high_impact	0.11	0.8	58.81	10.54	0.44	N	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3436	3436	G	C	MI.11029	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	130	44	G	R	Ggg/Cgg	-5.3	0	0	probably_damaging	1	neutral	0.35	neutral	1.09	deleterious	-7.33	deleterious	-7.23	high_impact	4.93	0.71	neutral	0.06	damaging	3.88	23.50	deleterious	0.02	0.35	0.54	disease	0.94	disease	0.84	disease	0.91	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.12	medium_impact	3.12	high_impact	0.52	0.8	58.81	10.54	0.6	P	0.99	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9044	9044	T	C	MI.1103	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	518	173	L	P	cTa/cCa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	3.48	deleterious	-7.72	deleterious	-6.29	high_impact	4.35	0.35	damaging	0.14	damaging	3.98	23.60	deleterious	0.12	0.65	0.63	disease	0.82	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.63	high_impact	0.70	0.9	48.67	8.82	0.54	P	1.00	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3437	3437	G	T	MI.11030	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	131	44	G	V	gGg/gTg	7.11	1	0	probably_damaging	1	neutral	0.51	neutral	1.09	deleterious	-7.12	deleterious	-8.13	high_impact	4.93	0.55	damaging	0.06	damaging	3.70	23.30	deleterious	0.02	0.35	0.75	disease	0.94	disease	0.75	disease	0.87	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.29	medium_impact	3.12	high_impact	0.15	0.8	58.81	10.54	0.65	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3437	3437	G	C	MI.11031	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	131	44	G	A	gGg/gCg	7.11	1	0	probably_damaging	1	neutral	0.5	neutral	1.13	deleterious	-5.7	deleterious	-5.42	high_impact	4.24	0.72	neutral	0.11	damaging	3.04	22.40	deleterious	0.03	0.35	0.55	disease	0.84	disease	0.72	disease	0.75	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.28	medium_impact	2.51	high_impact	0.33	0.8	58.81	10.54	0.6	P	0.76	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3437	3437	G	A	MI.11032	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	131	44	G	E	gGg/gAg	7.11	1	0	probably_damaging	1	neutral	0.27	neutral	1.1	deleterious	-6.73	deleterious	-7.23	high_impact	4.93	0.69	neutral	0.07	damaging	3.80	23.40	deleterious	0.02	0.35	0.67	disease	0.91	disease	0.84	disease	0.84	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.03	medium_impact	3.12	high_impact	0.21	0.8	58.81	10.54	0.77	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3439	3439	C	A	MI.11033	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	133	45	L	M	Cta/Ata	-8.51	0	0	benign	0.14	neutral	0.22	neutral	2.4	deleterious	-3.27	neutral	-1.64	medium_impact	2.91	0.8	neutral	0.68	neutral	3.62	23.20	deleterious	0.19	0.45	0.41	neutral	0.62	disease	0.47	neutral	0.48	neutral	0	0.75	neutral	0.54	deleterious	-3	neutral	0.25	neutral	-0.01	medium_impact	-0.03	medium_impact	1.35	medium_impact	0.56	0.8	24.21	25.63	0.38	N	0.45	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3439	3439	C	G	MI.11034	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	133	45	L	V	Cta/Gta	-8.51	0	0	benign	0.03	neutral	0.51	neutral	2.55	neutral	-1.66	neutral	-2.24	low_impact	1.87	0.83	neutral	0.8	neutral	3.26	22.80	deleterious	0.19	0.45	0.22	neutral	0.67	disease	0.3	neutral	0.45	neutral	1	0.45	neutral	0.74	deleterious	-6	neutral	0.22	neutral	0.67	medium_impact	0.29	medium_impact	0.45	medium_impact	0.49	0.8	24.21	25.63	0.33	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3440	3440	T	C	MI.11035	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	134	45	L	P	cTa/cCa	0.22	0.02	0	probably_damaging	0.92	neutral	0.21	neutral	2.35	deleterious	-5.1	deleterious	-5.92	high_impact	4.5	0.7	neutral	0.48	neutral	3.83	23.40	deleterious	0.02	0.35	0.68	disease	0.88	disease	0.76	disease	0.81	disease	6	0.95	neutral	0.15	neutral	2	deleterious	0.85	deleterious	-1.75	low_impact	-0.05	medium_impact	2.74	high_impact	0.26	0.8	24.21	25.63	0.56	P	0.96	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3440	3440	T	A	MI.11036	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	134	45	L	Q	cTa/cAa	0.22	0.02	0	possibly_damaging	0.89	neutral	0.29	neutral	2.36	deleterious	-4.82	deleterious	-5.13	high_impact	4.5	0.69	neutral	0.49	neutral	3.99	23.60	deleterious	0.03	0.35	0.61	disease	0.85	disease	0.65	disease	0.71	disease	4	0.91	neutral	0.2	neutral	1	deleterious	0.79	deleterious	-1.6	low_impact	0.06	medium_impact	2.74	high_impact	0.15	0.8	24.21	25.63	0.52	P	0.95	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3440	3440	T	G	MI.11037	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	134	45	L	R	cTa/cGa	0.22	0.02	0	possibly_damaging	0.89	neutral	0.35	neutral	2.36	deleterious	-4.64	deleterious	-5.15	high_impact	4.5	0.7	neutral	0.45	neutral	4.09	23.70	deleterious	0.02	0.35	0.5	neutral	0.92	disease	0.76	disease	0.81	disease	6	0.9	neutral	0.23	neutral	1	deleterious	0.80	deleterious	-1.6	low_impact	0.12	medium_impact	2.74	high_impact	0.10	0.8	24.21	25.63	0.57	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3442	3442	C	G	MI.11038	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	136	46	L	V	Cta/Gta	-5.52	0	0	possibly_damaging	0.68	neutral	0.5	neutral	2.43	neutral	-2.47	deleterious	-2.62	medium_impact	3.38	0.7	neutral	0.12	damaging	3.32	22.90	deleterious	0.14	0.4	0.32	neutral	0.7	disease	0.42	neutral	0.51	disease	0	0.66	neutral	0.41	neutral	0	NA	0.62	deleterious	-1.06	low_impact	0.28	medium_impact	1.76	medium_impact	0.48	0.8	56.6	9.86	0.28	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3442	3442	C	A	MI.11039	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	136	46	L	M	Cta/Ata	-5.52	0	0	probably_damaging	0.98	neutral	0.22	neutral	2.34	deleterious	-3.97	neutral	-1.72	medium_impact	3.21	0.75	neutral	0.14	damaging	3.64	23.20	deleterious	0.16	0.45	0.5	neutral	0.65	disease	0.41	neutral	0.48	neutral	0	0.98	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-2.34	low_impact	-0.03	medium_impact	1.62	medium_impact	0.44	0.8	56.6	9.86	0.33	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9044	9044	T	G	MI.1104	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	518	173	L	R	cTa/cGa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	3.48	deleterious	-7.36	deleterious	-5.36	high_impact	4.35	0.45	damaging	0.12	damaging	4.23	23.90	deleterious	0.11	0.65	0.89	disease	0.88	disease	0.73	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.63	high_impact	0.50	0.9	48.67	8.82	0.39	N	0.99	disease_causing	0.93	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3443	3443	T	G	MI.11040	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	137	46	L	R	cTa/cGa	-0.24	0	0	probably_damaging	0.99	neutral	0.35	neutral	2.32	deleterious	-4.69	deleterious	-5.3	high_impact	4.74	0.81	neutral	0.12	damaging	4.06	23.70	deleterious	0.01	0.35	0.63	disease	0.92	disease	0.7	disease	0.78	disease	6	0.99	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-2.62	low_impact	0.12	medium_impact	2.95	high_impact	0.16	0.8	56.6	9.86	0.6	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3443	3443	T	C	MI.11041	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	137	46	L	P	cTa/cCa	-0.24	0	0	probably_damaging	0.99	neutral	0.21	neutral	2.33	deleterious	-4.43	deleterious	-6.2	medium_impact	2.69	0.78	neutral	0.12	damaging	3.85	23.40	deleterious	0.01	0.35	0.57	disease	0.77	disease	0.5	neutral	0.53	disease	1	0.99	deleterious	0.11	neutral	1	deleterious	0.87	deleterious	-2.62	low_impact	-0.05	medium_impact	1.16	medium_impact	0.27	0.8	56.6	9.86	0.27	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3443	3443	T	A	MI.11042	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	137	46	L	Q	cTa/cAa	-0.24	0	0	probably_damaging	0.99	neutral	0.29	neutral	2.32	deleterious	-5.17	deleterious	-5.29	high_impact	4.74	0.75	neutral	0.12	damaging	4.13	23.80	deleterious	0.02	0.35	0.65	disease	0.85	disease	0.59	disease	0.69	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-2.62	low_impact	0.06	medium_impact	2.95	high_impact	0.24	0.8	56.6	9.86	0.6	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3445	3445	C	A	MI.11043	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	139	47	Q	K	Caa/Aaa	-13.34	0	0	probably_damaging	1	neutral	0.3	neutral	2.34	deleterious	-3.93	deleterious	-3.59	high_impact	4.58	0.59	damaging	0.04	damaging	3.83	23.40	deleterious	0.03	0.35	0.56	disease	0.92	disease	0.81	disease	0.81	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.07	medium_impact	2.81	high_impact	0.47	0.8	59.43	10.46	0.53	N	0.98	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3445	3445	C	G	MI.11044	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	139	47	Q	E	Caa/Gaa	-13.34	0	0	probably_damaging	1	neutral	0.28	neutral	2.32	deleterious	-4.42	deleterious	-2.69	high_impact	4.93	0.62	neutral	0.06	damaging	3.02	22.30	deleterious	0.06	0.35	0.61	disease	0.81	disease	0.8	disease	0.75	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.05	medium_impact	3.12	high_impact	0.48	0.8	59.43	10.46	0.7	P	0.93	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3446	3446	A	G	MI.11045	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	140	47	Q	R	cAa/cGa	4.35	1	0	probably_damaging	1	neutral	0.35	neutral	2.31	deleterious	-4.41	deleterious	-3.59	high_impact	4.93	0.58	damaging	0.04	damaging	3.27	22.80	deleterious	0.04	0.35	0.61	disease	0.92	disease	0.82	disease	0.82	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.12	medium_impact	3.12	high_impact	0.37	0.8	59.43	10.46	0.8	P	0.95	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3446	3446	A	T	MI.11046	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	140	47	Q	L	cAa/cTa	4.35	1	0	probably_damaging	1	neutral	0.66	neutral	2.27	deleterious	-5.44	deleterious	-6.28	high_impact	4.24	0.62	neutral	0.04	damaging	3.56	23.10	deleterious	0.02	0.35	0.75	disease	0.92	disease	0.72	disease	0.76	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.44	medium_impact	2.51	high_impact	0.27	0.8	59.43	10.46	0.58	P	0.99	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3446	3446	A	C	MI.11047	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	140	47	Q	P	cAa/cCa	4.35	1	0	probably_damaging	1	neutral	0.22	neutral	2.25	deleterious	-6.42	deleterious	-5.39	high_impact	4.38	0.53	damaging	0.05	damaging	3.18	22.70	deleterious	0.02	0.35	0.82	disease	0.91	disease	0.83	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	-0.03	medium_impact	2.64	high_impact	0.28	0.8	59.43	10.46	0.62	P	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3447	3447	A	T	MI.11048	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	141	47	Q	H	caA/caT	6.65	1	0.02	probably_damaging	1	neutral	0.54	neutral	2.25	deleterious	-4.75	deleterious	-4.49	high_impact	4.12	0.61	neutral	0.04	damaging	3.93	23.50	deleterious	0.03	0.35	0.82	disease	0.86	disease	0.78	disease	0.8	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.31	medium_impact	2.41	high_impact	0.58	0.8	59.43	10.46	0.68	P	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3447	3447	A	C	MI.11049	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	141	47	Q	H	caA/caC	6.65	1	0.02	probably_damaging	1	neutral	0.54	neutral	2.25	deleterious	-4.75	deleterious	-4.49	high_impact	4.12	0.61	neutral	0.04	damaging	3.78	23.40	deleterious	0.03	0.35	0.82	disease	0.86	disease	0.78	disease	0.8	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.31	medium_impact	2.41	high_impact	0.58	0.8	59.43	10.46	0.67	P	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9044	9044	T	A	MI.1105	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	518	173	L	Q	cTa/cAa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	3.49	deleterious	-7.28	deleterious	-5.36	high_impact	4.35	0.51	damaging	0.14	damaging	4.18	23.80	deleterious	0.13	0.65	0.9	disease	0.82	disease	0.61	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.63	high_impact	0.59	0.9	48.67	8.82	0.35	N	0.98	disease_causing	0.91	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3448	3448	C	T	MI.11050	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	142	48	P	S	Ccc/Tcc	0.91	1	0	probably_damaging	1	neutral	0.4	neutral	2.65	neutral	-1.71	deleterious	-7.28	medium_impact	2.9	0.51	damaging	0.06	damaging	3.75	23.30	deleterious	0.1	0.4	0.23	neutral	0.86	disease	0.55	disease	0.64	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.18	medium_impact	1.34	medium_impact	0.15	0.8	60.38	10.42	0.38	N	0.74	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3448	3448	C	A	MI.11051	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	142	48	P	T	Ccc/Acc	0.91	1	0	probably_damaging	1	neutral	0.39	neutral	2.62	neutral	-2.01	deleterious	-7.28	medium_impact	3.07	0.55	damaging	0.05	damaging	3.74	23.30	deleterious	0.07	0.35	0.27	neutral	0.85	disease	0.54	disease	0.64	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	0.17	medium_impact	1.49	medium_impact	0.72	0.85	60.38	10.42	0.35	N	0.91	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3448	3448	C	G	MI.11052	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	142	48	P	A	Ccc/Gcc	0.91	1	0	probably_damaging	1	neutral	0.5	neutral	2.74	neutral	-1.77	deleterious	-7.28	medium_impact	3.02	0.57	damaging	0.07	damaging	2.98	22.20	deleterious	0.07	0.35	0.19	neutral	0.75	disease	0.65	disease	0.67	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.28	medium_impact	1.45	medium_impact	0.73	0.85	60.38	10.42	0.36	N	0.78	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3449	3449	C	G	MI.11053	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	143	48	P	R	cCc/cGc	5.5	1	0	probably_damaging	1	neutral	0.35	neutral	2.57	deleterious	-3.04	deleterious	-8.19	high_impact	4.82	0.58	damaging	0.04	damaging	3.54	23.10	deleterious	0.02	0.35	0.32	neutral	0.93	disease	0.75	disease	0.82	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.12	medium_impact	3.02	high_impact	0.39	0.8	60.38	10.42	0.68	P	0.71	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3449	3449	C	T	MI.11054	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	143	48	P	L	cCc/cTc	5.5	1	0	probably_damaging	1	neutral	0.67	neutral	2.61	neutral	-1.96	deleterious	-9.1	medium_impact	3.4	0.6	damaging	0.04	damaging	4.26	23.90	deleterious	0.05	0.35	0.25	neutral	0.9	disease	0.64	disease	0.72	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.45	medium_impact	1.78	medium_impact	0.70	0.85	60.38	10.42	0.48	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3449	3449	C	A	MI.11055	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	143	48	P	H	cCc/cAc	5.5	1	0	probably_damaging	1	neutral	0.54	neutral	2.54	deleterious	-3.91	deleterious	-8.19	high_impact	4.82	0.57	damaging	0.04	damaging	4.10	23.70	deleterious	0.04	0.35	0.47	neutral	0.89	disease	0.75	disease	0.78	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.31	medium_impact	3.02	high_impact	0.35	0.8	60.38	10.42	0.7	P	0.69	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3451	3451	T	C	MI.11056	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	145	49	F	L	Ttc/Ctc	-10.81	0	0	benign	0.39	neutral	0.67	neutral	3.01	neutral	1.09	neutral	0.27	neutral_impact	0.78	0.8	neutral	0.72	neutral	2.86	21.70	deleterious	0.15	0.4	0.12	neutral	0.67	disease	0.27	neutral	0.44	neutral	1	0.31	neutral	0.64	deleterious	-6	neutral	0.26	neutral	-0.57	medium_impact	0.45	medium_impact	-0.51	medium_impact	0.75	0.85	19.81	25.29	0.25	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3451	3451	T	G	MI.11057	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	145	49	F	V	Ttc/Gtc	-10.81	0	0	benign	0.26	neutral	0.5	neutral	2.87	neutral	0.44	neutral	0.83	neutral_impact	0.76	0.86	neutral	0.95	neutral	2.77	21.20	deleterious	0.05	0.35	0.16	neutral	0.76	disease	0.27	neutral	0.49	neutral	0	0.4	neutral	0.62	deleterious	-6	neutral	0.24	neutral	-0.32	medium_impact	0.28	medium_impact	-0.53	medium_impact	0.35	0.8	19.81	25.29	0.26	N	0.74	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3451	3451	T	A	MI.11058	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	145	49	F	I	Ttc/Atc	-10.81	0	0	benign	0.05	neutral	0.4	neutral	2.88	neutral	0.48	neutral	1.43	neutral_impact	-0.41	0.7	neutral	0.95	neutral	1.59	13.81	neutral	0.11	0.4	0.14	neutral	0.18	neutral	0.18	neutral	0.28	neutral	4	0.56	neutral	0.68	deleterious	-6	neutral	0.11	neutral	0.45	medium_impact	0.18	medium_impact	-1.55	low_impact	0.52	0.8	19.81	25.29	0.47	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3452	3452	T	A	MI.11059	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	146	49	F	Y	tTc/tAc	-0.7	0	0	possibly_damaging	0.83	neutral	1	neutral	2.63	neutral	-2.93	neutral	-1.19	high_impact	3.56	0.75	neutral	0.57	neutral	4.18	23.80	deleterious	0.1	0.4	0.23	neutral	0.74	disease	0.51	disease	0.58	disease	2	0.83	neutral	0.59	deleterious	1	deleterious	0.62	deleterious	-1.4	low_impact	1.96	high_impact	1.92	medium_impact	0.57	0.8	19.81	25.29	0.37	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9046	9046	A	T	MI.1106	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	520	174	I	F	Att/Ttt	-1.72	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.23	neutral	-1.39	deleterious	-3.23	medium_impact	2.23	0.7	neutral	0.45	neutral	3.84	23.40	deleterious	0.27	0.65	0.45	neutral	0.72	disease	0.65	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-2.65	low_impact	-0.84	medium_impact	0.81	medium_impact	0.87	0.9	20.8	19.14	0.31	N	0.97	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3452	3452	T	G	MI.11060	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	146	49	F	C	tTc/tGc	-0.7	0	0	probably_damaging	0.98	neutral	0.17	neutral	2.62	deleterious	-3.71	neutral	-2.19	medium_impact	3.21	0.72	neutral	0.43	neutral	4.05	23.70	deleterious	0.03	0.35	0.59	disease	0.88	disease	0.55	disease	0.75	disease	5	0.99	deleterious	0.1	neutral	1	deleterious	0.77	deleterious	-2.34	low_impact	-0.11	medium_impact	1.62	medium_impact	0.19	0.8	19.81	25.29	0.36	N	0.80	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3452	3452	T	C	MI.11061	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	146	49	F	S	tTc/tCc	-0.7	0	0	probably_damaging	0.93	neutral	0.4	neutral	2.64	neutral	-2.67	deleterious	-2.86	medium_impact	3.21	0.71	neutral	0.52	neutral	4.19	23.80	deleterious	0.02	0.35	0.41	neutral	0.82	disease	0.55	disease	0.73	disease	5	0.93	neutral	0.24	neutral	1	deleterious	0.74	deleterious	-1.81	low_impact	0.18	medium_impact	1.62	medium_impact	0.17	0.8	19.81	25.29	0.38	N	0.94	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3453	3453	C	G	MI.11062	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	147	49	F	L	ttC/ttG	5.73	0.86	0	benign	0.39	neutral	0.67	neutral	3.01	neutral	1.09	neutral	0.27	neutral_impact	0.78	0.8	neutral	0.72	neutral	3.14	22.60	deleterious	0.15	0.4	0.12	neutral	0.67	disease	0.27	neutral	0.44	neutral	1	0.31	neutral	0.64	deleterious	-6	neutral	0.26	neutral	-0.57	medium_impact	0.45	medium_impact	-0.51	medium_impact	0.75	0.85	19.81	25.29	0.36	N	0.66	polymorphism	1	0.01	rs386828907	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3453	3453	C	A	MI.11063	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	147	49	F	L	ttC/ttA	5.73	0.86	0	benign	0.39	neutral	0.67	neutral	3.01	neutral	1.09	neutral	0.27	neutral_impact	0.78	0.8	neutral	0.72	neutral	3.47	23.00	deleterious	0.15	0.4	0.12	neutral	0.67	disease	0.27	neutral	0.44	neutral	1	0.31	neutral	0.64	deleterious	-6	neutral	0.26	neutral	-0.57	medium_impact	0.45	medium_impact	-0.51	medium_impact	0.75	0.85	19.81	25.29	0.36	N	0.66	polymorphism	1	0.01	rs386828907	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3454	3454	G	T	MI.11064	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	148	50	A	S	Gct/Tct	-7.59	0	0	probably_damaging	1	neutral	0.41	neutral	2.58	deleterious	-3.46	deleterious	-2.72	low_impact	1.62	0.76	neutral	0.18	damaging	3.58	23.20	deleterious	0.22	0.45	0.38	neutral	0.58	disease	0.19	neutral	0.42	neutral	2	1	deleterious	0.21	neutral	-2	neutral	0.78	deleterious	-3.57	low_impact	0.19	medium_impact	0.23	medium_impact	0.53	0.8	59.12	10.29	0.38	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3454	3454	G	A	MI.11065	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	148	50	A	T	Gct/Act	-7.59	0	0	probably_damaging	1	neutral	0.4	neutral	2.57	neutral	-2.92	deleterious	-3.63	high_impact	4.1	0.78	neutral	0.16	damaging	4.14	23.80	deleterious	0.11	0.4	0.33	neutral	0.82	disease	0.41	neutral	0.63	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.18	medium_impact	2.39	high_impact	0.72	0.85	59.12	10.29	0.35	N	0.70	polymorphism	1	0.17	.	.	.	.	.	.	COSM1155616	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3454	3454	G	C	MI.11066	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	148	50	A	P	Gct/Cct	-7.59	0	0	probably_damaging	1	neutral	0.22	neutral	2.51	deleterious	-5.19	deleterious	-4.56	high_impact	4.3	0.71	neutral	0.07	damaging	3.73	23.30	deleterious	0.02	0.35	0.65	disease	0.9	disease	0.67	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.03	medium_impact	2.57	high_impact	0.44	0.8	59.12	10.29	0.41	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3455	3455	C	G	MI.11067	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	149	50	A	G	gCt/gGt	5.96	1	0	probably_damaging	1	neutral	0.36	neutral	2.52	deleterious	-4.31	deleterious	-3.65	medium_impact	3.5	0.76	neutral	0.1	damaging	3.90	23.50	deleterious	0.15	0.45	0.57	disease	0.79	disease	0.4	neutral	0.61	disease	2	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.14	medium_impact	1.87	medium_impact	0.65	0.8	59.12	10.29	0.57	P	0.79	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3455	3455	C	A	MI.11068	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	149	50	A	D	gCt/gAt	5.96	1	0	probably_damaging	1	neutral	0.22	neutral	2.52	deleterious	-5.28	deleterious	-5.47	high_impact	4.65	0.78	neutral	0.1	damaging	4.38	24.10	deleterious	0.02	0.35	0.63	disease	0.92	disease	0.67	disease	0.75	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.03	medium_impact	2.87	high_impact	0.33	0.8	59.12	10.29	0.63	P	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3455	3455	C	T	MI.11069	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	149	50	A	V	gCt/gTt	5.96	1	0	probably_damaging	1	neutral	0.51	neutral	2.61	neutral	-2.48	deleterious	-3.65	medium_impact	3.45	0.68	neutral	0.06	damaging	4.33	24.00	deleterious	0.06	0.35	0.29	neutral	0.85	disease	0.52	disease	0.69	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.29	medium_impact	1.82	medium_impact	0.68	0.85	59.12	10.29	0.55	P	0.72	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9046	9046	A	C	MI.1107	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	520	174	I	L	Att/Ctt	-1.72	0	0	probably_damaging	0.93	neutral	0.93	neutral	4.7	neutral	1.25	neutral	-1.46	low_impact	0.9	0.81	neutral	0.68	neutral	2.74	21.00	deleterious	0.37	0.65	0.43	neutral	0.28	neutral	0.39	neutral	0.44	neutral	1	0.92	neutral	0.5	deleterious	-2	neutral	0.61	deleterious	-1.82	low_impact	0.93	medium_impact	-0.33	medium_impact	0.74	0.9	20.8	19.14	0.24	N	0.83	disease_causing	0.6	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3457	3457	G	T	MI.11070	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	151	51	D	Y	Gac/Tac	-5.52	0	0	probably_damaging	1	neutral	1	neutral	1.54	deleterious	-9.02	deleterious	-8.23	high_impact	4.95	0.67	neutral	0.1	damaging	3.80	23.40	deleterious	0.02	0.35	0.92	disease	0.92	disease	0.72	disease	0.82	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.91	deleterious	-3.57	low_impact	1.96	high_impact	3.13	high_impact	0.14	0.8	60.06	10.34	0.57	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3457	3457	G	A	MI.11071	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	151	51	D	N	Gac/Aac	-5.52	0	0	probably_damaging	1	neutral	0.36	neutral	1.59	deleterious	-6.27	deleterious	-4.56	high_impact	4.4	0.68	neutral	0.11	damaging	4.11	23.70	deleterious	0.16	0.45	0.6	disease	0.85	disease	0.6	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.14	medium_impact	2.65	high_impact	0.51	0.8	60.06	10.34	0.46	N	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3457	3457	G	C	MI.11072	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	151	51	D	H	Gac/Cac	-5.52	0	0	probably_damaging	1	neutral	0.55	neutral	1.55	deleterious	-7.29	deleterious	-6.4	high_impact	4.61	0.66	neutral	0.1	damaging	3.56	23.10	deleterious	0.02	0.35	0.85	disease	0.85	disease	0.72	disease	0.79	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.32	medium_impact	2.84	high_impact	0.45	0.8	60.06	10.34	0.43	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3458	3458	A	G	MI.11073	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	152	51	D	G	gAc/gGc	7.11	1	0	probably_damaging	1	neutral	0.41	neutral	1.57	deleterious	-7.14	deleterious	-6.4	high_impact	4.61	0.76	neutral	0.14	damaging	3.96	23.60	deleterious	0.03	0.35	0.74	disease	0.85	disease	0.68	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.19	medium_impact	2.84	high_impact	0.20	0.8	60.06	10.34	0.61	P	0.99	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3458	3458	A	T	MI.11074	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	152	51	D	V	gAc/gTc	7.11	1	0	probably_damaging	1	neutral	0.54	neutral	1.55	deleterious	-8.87	deleterious	-8.23	high_impact	4.95	0.63	neutral	0.11	damaging	3.68	23.30	deleterious	0.02	0.35	0.89	disease	0.91	disease	0.67	disease	0.78	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.31	medium_impact	3.13	high_impact	0.08	0.8	60.06	10.34	0.65	P	1.00	polymorphism	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3458	3458	A	C	MI.11075	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	152	51	D	A	gAc/gCc	7.11	1	0	probably_damaging	1	neutral	0.61	neutral	1.58	deleterious	-7.04	deleterious	-7.32	high_impact	4.61	0.68	neutral	0.12	damaging	3.61	23.20	deleterious	0.03	0.35	0.74	disease	0.81	disease	0.67	disease	0.68	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.38	medium_impact	2.84	high_impact	0.25	0.8	60.06	10.34	0.6	P	0.94	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3459	3459	C	A	MI.11076	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	153	51	D	E	gaC/gaA	8.49	1	0	probably_damaging	1	neutral	0.38	neutral	1.64	deleterious	-5.26	deleterious	-3.66	high_impact	4.95	0.72	neutral	0.13	damaging	4.13	23.80	deleterious	0.06	0.35	0.53	disease	0.75	disease	0.6	disease	0.66	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.16	medium_impact	3.13	high_impact	0.39	0.8	60.06	10.34	0.76	P	0.95	polymorphism	0.96	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3459	3459	C	G	MI.11077	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	153	51	D	E	gaC/gaG	8.49	1	0	probably_damaging	1	neutral	0.38	neutral	1.64	deleterious	-5.26	deleterious	-3.66	high_impact	4.95	0.72	neutral	0.13	damaging	3.79	23.40	deleterious	0.06	0.35	0.53	disease	0.75	disease	0.6	disease	0.66	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.16	medium_impact	3.13	high_impact	0.39	0.8	60.06	10.34	0.76	P	0.95	polymorphism	0.96	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3460	3460	G	T	MI.11078	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	154	52	A	S	Gcc/Tcc	-7.82	0	0.05	probably_damaging	1	neutral	0.6	neutral	2.64	neutral	-2.08	neutral	-0.79	medium_impact	3.36	0.75	neutral	0.49	neutral	3.60	23.20	deleterious	0.2	0.45	0.35	neutral	0.75	disease	0.65	disease	0.7	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.37	medium_impact	1.75	medium_impact	0.48	0.8	60.06	10.07	0.37	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3460	3460	G	C	MI.11079	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	154	52	A	P	Gcc/Ccc	-7.82	0	0.05	probably_damaging	1	neutral	0.31	neutral	2.56	deleterious	-3.8	deleterious	-2.62	high_impact	4.05	0.52	damaging	0.27	damaging	3.77	23.40	deleterious	0.02	0.35	0.6	disease	0.93	disease	0.76	disease	0.83	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.08	medium_impact	2.35	high_impact	0.56	0.8	60.06	10.07	0.46	N	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9046	9046	A	G	MI.1108	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	520	174	I	V	Att/Gtt	-1.72	0	0	probably_damaging	0.93	neutral	0.06	neutral	4.24	neutral	-1.28	neutral	-0.68	low_impact	1.89	0.76	neutral	0.64	neutral	2.03	16.41	deleterious	0.45	0.65	0.66	disease	0.3	neutral	0.42	neutral	0.59	disease	2	0.98	deleterious	0.07	neutral	-2	neutral	0.65	deleterious	-1.82	low_impact	-0.38	medium_impact	0.52	medium_impact	0.72	0.9	20.8	19.14	0.45	N	0.77	polymorphism	0.61	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3460	3460	G	A	MI.11080	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	154	52	A	T	Gcc/Acc	-7.82	0	0.05	probably_damaging	1	neutral	0.54	neutral	2.62	neutral	-1.54	neutral	-2.36	medium_impact	3.08	0.29	damaging	0.45	neutral	4.24	23.90	deleterious	0.13	0.4	0.26	neutral	0.72	disease	0.65	disease	0.7	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.31	medium_impact	1.5	medium_impact	0.78	0.85	60.06	10.07	0.86	P	0.70	disease_causing_automatic	0	0.13	rs199476118	Pathogenic	Leber's_optic_atrophy|Leigh_syndrome|Mitochondrial_complex_I_deficiency	24761	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838979,OMIM:252010	.	COSM6716712	.	.	G3460A	LHON	+	+	Cfrm	141	P	P	P	damaging
chrM	3461	3461	C	T	MI.11081	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	155	52	A	V	gCc/gTc	5.96	1	0	probably_damaging	1	neutral	0.58	neutral	2.6	neutral	0.03	deleterious	-3.02	medium_impact	2.37	0.54	damaging	0.52	neutral	4.43	24.20	deleterious	0.08	0.35	0.19	neutral	0.81	disease	0.65	disease	0.73	disease	5	1	deleterious	0.29	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.35	medium_impact	0.88	medium_impact	0.80	0.85	60.06	10.07	0.59	P	0.72	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3461	3461	C	A	MI.11082	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	155	52	A	D	gCc/gAc	5.96	1	0	probably_damaging	1	neutral	0.39	neutral	2.57	deleterious	-4.26	neutral	-2.23	high_impact	4.05	0.59	damaging	0.38	neutral	4.46	24.20	deleterious	0.01	0.35	0.56	disease	0.92	disease	0.74	disease	0.81	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.17	medium_impact	2.35	high_impact	0.25	0.8	60.06	10.07	0.7	P	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3461	3461	C	G	MI.11083	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	155	52	A	G	gCc/gGc	5.96	1	0	probably_damaging	1	neutral	0.44	neutral	2.9	neutral	0.07	neutral	2.87	neutral_impact	-0.2	0.77	neutral	0.64	neutral	1.18	11.63	neutral	0.2	0.45	0.15	neutral	0.1	neutral	0.32	neutral	0.23	neutral	5	1	deleterious	0.22	neutral	-2	neutral	0.69	deleterious	-3.57	low_impact	0.22	medium_impact	-1.36	low_impact	0.62	0.8	60.06	10.07	0.59	P	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3463	3463	A	C	MI.11084	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	157	53	M	L	Ata/Cta	-20	0	0	benign	0.01	neutral	0.66	neutral	3.06	neutral	2.32	neutral	0.46	neutral_impact	-0.6	0.84	neutral	0.96	neutral	-0.36	0.49	neutral	0.26	0.45	0.19	neutral	0.18	neutral	0.17	neutral	0.27	neutral	5	0.32	neutral	0.83	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.44	medium_impact	-1.71	low_impact	0.39	0.8	20.75	31.37	0.44	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3463	3463	A	G	MI.11085	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	157	53	M	V	Ata/Gta	-20	0	0	benign	0.01	neutral	0.51	neutral	3.05	neutral	2.29	neutral	0.62	neutral_impact	-1.22	0.77	neutral	0.98	neutral	-1.88	0.00	neutral	0.23	0.45	0.16	neutral	0.11	neutral	0.17	neutral	0.27	neutral	5	0.48	neutral	0.75	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.29	medium_impact	-2.25	low_impact	0.36	0.8	20.75	31.37	0.46	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3463	3463	A	T	MI.11086	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	157	53	M	L	Ata/Tta	-20	0	0	benign	0.01	neutral	0.66	neutral	3.06	neutral	2.32	neutral	0.46	neutral_impact	-0.6	0.84	neutral	0.96	neutral	-0.20	1.08	neutral	0.26	0.45	0.19	neutral	0.18	neutral	0.17	neutral	0.27	neutral	5	0.32	neutral	0.83	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.44	medium_impact	-1.71	low_impact	0.39	0.8	20.75	31.37	0.43	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3464	3464	T	C	MI.11087	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	158	53	M	T	aTa/aCa	-3.92	0	0	benign	0.36	neutral	0.41	neutral	2.82	neutral	0.24	neutral	-2.18	low_impact	1.23	0.86	neutral	0.78	neutral	0.98	10.56	neutral	0.09	0.35	0.16	neutral	0.4	neutral	0.49	neutral	0.45	neutral	1	0.52	neutral	0.53	deleterious	-6	neutral	0.39	neutral	-0.52	medium_impact	0.19	medium_impact	-0.11	medium_impact	0.14	0.8	20.75	31.37	0.29	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3464	3464	T	A	MI.11088	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	158	53	M	K	aTa/aAa	-3.92	0	0	possibly_damaging	0.6	neutral	0.32	neutral	2.77	neutral	-1.26	deleterious	-3.48	medium_impact	2.55	0.67	neutral	0.48	neutral	2.03	16.42	deleterious	0.03	0.35	0.24	neutral	0.68	disease	0.56	disease	0.71	disease	4	0.7	neutral	0.36	neutral	0	NA	0.55	deleterious	-0.92	medium_impact	0.09	medium_impact	1.04	medium_impact	0.21	0.8	20.75	31.37	0.39	N	0.67	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3465	3465	A	T	MI.11089	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	159	53	M	I	atA/atT	4.58	0.65	0	benign	0.17	neutral	0.4	neutral	3.03	neutral	2.2	neutral	0.68	neutral_impact	-1.32	0.78	neutral	0.99	neutral	-0.16	1.30	neutral	0.27	0.45	0.17	neutral	0.14	neutral	0.14	neutral	0.24	neutral	5	0.52	neutral	0.62	deleterious	-6	neutral	0.17	neutral	-0.1	medium_impact	0.18	medium_impact	-2.34	low_impact	0.48	0.8	20.75	31.37	0.48	N	0.00	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9047	9047	T	C	MI.1109	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	521	174	I	T	aTt/aCt	5.68	1	0	probably_damaging	0.99	deleterious	0.01	neutral	4.2	neutral	-1.92	deleterious	-3.35	medium_impact	2.94	0.84	neutral	0.75	neutral	2.37	18.64	deleterious	0.33	0.65	0.85	disease	0.52	disease	0.47	neutral	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-2.65	low_impact	-0.84	medium_impact	1.42	medium_impact	0.62	0.9	20.8	19.14	0.51	P	0.99	disease_causing	1	0.06	.	.	.	.	.	.	COSM6716147	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3465	3465	A	C	MI.11090	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	159	53	M	I	atA/atC	4.58	0.65	0	benign	0.17	neutral	0.4	neutral	3.03	neutral	2.2	neutral	0.68	neutral_impact	-1.32	0.78	neutral	0.99	neutral	-0.24	0.90	neutral	0.27	0.45	0.17	neutral	0.14	neutral	0.14	neutral	0.24	neutral	5	0.52	neutral	0.62	deleterious	-6	neutral	0.17	neutral	-0.1	medium_impact	0.18	medium_impact	-2.34	low_impact	0.48	0.8	20.75	31.37	0.47	N	0.00	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3466	3466	A	G	MI.11091	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	160	54	K	E	Aaa/Gaa	-2.77	0	0	probably_damaging	1	neutral	0.46	neutral	1.81	deleterious	-6.84	deleterious	-3.67	high_impact	4.61	0.76	neutral	0.14	damaging	3.95	23.60	deleterious	0.05	0.35	0.69	disease	0.75	disease	0.57	disease	0.65	disease	3	1	deleterious	0.23	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.24	medium_impact	2.84	high_impact	0.35	0.8	60.06	10.66	0.51	N	0.92	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3466	3466	A	C	MI.11092	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	160	54	K	Q	Aaa/Caa	-2.77	0	0	probably_damaging	1	neutral	0.45	neutral	1.81	deleterious	-6.17	deleterious	-3.67	high_impact	4.96	0.73	neutral	0.14	damaging	3.38	22.90	deleterious	0.09	0.35	0.62	disease	0.77	disease	0.51	disease	0.6	disease	2	1	deleterious	0.23	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.23	medium_impact	3.14	high_impact	0.41	0.8	60.06	10.66	0.68	P	0.92	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3467	3467	A	T	MI.11093	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	161	54	K	M	aAa/aTa	6.65	1	0	probably_damaging	1	neutral	0.25	neutral	1.76	deleterious	-8.87	deleterious	-5.51	high_impact	4.96	0.82	neutral	0.15	damaging	3.73	23.30	deleterious	0.03	0.35	0.89	disease	0.78	disease	0.54	disease	0.71	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.01	medium_impact	3.14	high_impact	0.15	0.8	60.06	10.66	0.69	P	0.50	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3467	3467	A	C	MI.11094	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	161	54	K	T	aAa/aCa	6.65	1	0	probably_damaging	1	neutral	0.5	neutral	1.79	deleterious	-7.24	deleterious	-5.51	high_impact	4.96	0.7	neutral	0.11	damaging	3.50	23.10	deleterious	0.05	0.35	0.76	disease	0.75	disease	0.53	disease	0.63	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.28	medium_impact	3.14	high_impact	0.23	0.8	60.06	10.66	0.7	P	0.82	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3468	3468	A	C	MI.11095	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	162	54	K	N	aaA/aaC	8.49	1	0	probably_damaging	1	neutral	0.4	neutral	1.79	deleterious	-7.24	deleterious	-4.59	high_impact	4.96	0.74	neutral	0.11	damaging	3.71	23.30	deleterious	0.07	0.35	0.75	disease	0.78	disease	0.44	neutral	0.63	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.18	medium_impact	3.14	high_impact	0.24	0.8	60.06	10.66	0.72	P	0.84	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3468	3468	A	T	MI.11096	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	162	54	K	N	aaA/aaT	8.49	1	0	probably_damaging	1	neutral	0.4	neutral	1.79	deleterious	-7.24	deleterious	-4.59	high_impact	4.96	0.74	neutral	0.11	damaging	3.76	23.30	deleterious	0.07	0.35	0.75	disease	0.78	disease	0.44	neutral	0.63	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.18	medium_impact	3.14	high_impact	0.24	0.8	60.06	10.66	0.72	P	0.84	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3469	3469	C	T	MI.11097	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	163	55	L	F	Ctc/Ttc	2.06	0.99	0	probably_damaging	1	neutral	0.35	neutral	2.12	deleterious	-3.74	deleterious	-3.65	high_impact	3.67	0.58	damaging	0.32	neutral	3.88	23.50	deleterious	0.08	0.35	0.48	neutral	0.67	disease	0.52	disease	0.57	disease	1	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.12	medium_impact	2.02	high_impact	0.51	0.8	58.81	10.4	0.6	P	0.95	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3469	3469	C	A	MI.11098	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	163	55	L	I	Ctc/Atc	2.06	0.99	0	probably_damaging	1	neutral	0.35	neutral	2.18	neutral	-2.85	neutral	-1.82	high_impact	3.77	0.67	neutral	0.45	neutral	4.17	23.80	deleterious	0.17	0.45	0.43	neutral	0.59	disease	0.62	disease	0.65	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.12	medium_impact	2.1	high_impact	0.55	0.8	58.81	10.4	0.62	P	0.83	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3469	3469	C	G	MI.11099	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	163	55	L	V	Ctc/Gtc	2.06	0.99	0	probably_damaging	1	neutral	0.47	neutral	2.17	neutral	-2.97	deleterious	-2.74	high_impact	3.94	0.6	neutral	0.32	neutral	3.35	22.90	deleterious	0.12	0.4	0.43	neutral	0.6	disease	0.62	disease	0.65	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.25	medium_impact	2.25	high_impact	0.54	0.8	58.81	10.4	0.55	P	0.84	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8578	8578	C	A	MI.111	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	52	18	P	T	Ccc/Acc	-12.13	0	0	probably_damaging	1	neutral	0.05	neutral	4.64	neutral	0.92	deleterious	-6.61	medium_impact	2.75	0.82	neutral	0.69	neutral	3.45	23.00	deleterious	0.35	0.65	0.32	neutral	0.75	disease	0.65	disease	0.64	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.43	medium_impact	1.26	medium_impact	0.79	0.9	21.24	15.57	0.37	N	0.42	polymorphism	0.95	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9047	9047	T	A	MI.1110	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	521	174	I	N	aTt/aAt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	4.14	deleterious	-4.2	deleterious	-5.44	high_impact	3.98	0.72	neutral	0.47	neutral	4.54	24.30	deleterious	0.22	0.65	0.94	disease	0.76	disease	0.65	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-1.4	low_impact	2.31	high_impact	0.68	0.9	20.8	19.14	0.5	N	1.00	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3470	3470	T	A	MI.11100	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	164	55	L	H	cTc/cAc	-0.01	0.94	0	probably_damaging	1	neutral	0.33	neutral	2.07	deleterious	-5.87	deleterious	-6.38	high_impact	4.92	0.62	neutral	0.3	neutral	4.26	23.90	deleterious	0.02	0.35	0.83	disease	0.78	disease	0.71	disease	0.75	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.1	medium_impact	3.11	high_impact	0.30	0.8	58.81	10.4	0.65	P	0.97	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3470	3470	T	G	MI.11101	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	164	55	L	R	cTc/cGc	-0.01	0.94	0	probably_damaging	1	neutral	0.61	neutral	2.08	deleterious	-5.19	deleterious	-5.47	high_impact	4.92	0.64	neutral	0.27	damaging	4.14	23.80	deleterious	0.01	0.35	0.76	disease	0.88	disease	0.75	disease	0.79	disease	6	1	deleterious	0.31	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.38	medium_impact	3.11	high_impact	0.12	0.8	58.81	10.4	0.71	P	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3470	3470	T	C	MI.11102	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	164	55	L	P	cTc/cCc	-0.01	0.94	0	probably_damaging	1	neutral	0.34	neutral	2.06	deleterious	-6.05	deleterious	-6.39	high_impact	4.57	0.63	neutral	0.33	neutral	3.89	23.50	deleterious	0.01	0.35	0.82	disease	0.8	disease	0.75	disease	0.8	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.11	medium_impact	2.8	high_impact	0.24	0.8	58.81	10.4	0.56	P	1.00	polymorphism	1	0.47	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3472	3472	T	C	MI.11103	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	166	56	F	L	Ttc/Ctc	-3	0	0	possibly_damaging	0.74	neutral	0.71	neutral	2.86	neutral	1.15	deleterious	-4.87	low_impact	1.66	0.68	neutral	0.58	neutral	3.90	23.50	deleterious	0.19	0.45	0.12	neutral	0.61	disease	0.26	neutral	0.41	neutral	2	0.69	neutral	0.49	deleterious	-3	neutral	0.59	deleterious	-1.18	low_impact	0.49	medium_impact	0.26	medium_impact	0.77	0.85	60.69	10.14	0.46	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	CPD	0.15	T3472C	LHON	+	-	Reported	2	.	P	P	neutral
chrM	3472	3472	T	G	MI.11104	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	166	56	F	V	Ttc/Gtc	-3	0	0	possibly_damaging	0.83	neutral	0.54	neutral	2.82	neutral	-0.19	deleterious	-5.87	medium_impact	2.9	0.67	neutral	0.64	neutral	3.97	23.60	deleterious	0.06	0.35	0.22	neutral	0.83	disease	0.54	disease	0.68	disease	4	0.81	neutral	0.36	neutral	0	NA	0.67	deleterious	-1.4	low_impact	0.31	medium_impact	1.34	medium_impact	0.33	0.8	60.69	10.14	0.41	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3472	3472	T	A	MI.11105	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	166	56	F	I	Ttc/Atc	-3	0	0	possibly_damaging	0.88	neutral	0.41	neutral	2.8	neutral	-0.29	deleterious	-4.96	medium_impact	2.1	0.76	neutral	0.72	neutral	4.32	24.00	deleterious	0.12	0.4	0.18	neutral	0.67	disease	0.42	neutral	0.44	neutral	1	0.88	neutral	0.27	neutral	0	NA	0.69	deleterious	-1.56	low_impact	0.19	medium_impact	0.65	medium_impact	0.44	0.8	60.69	10.14	0.43	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3473	3473	T	A	MI.11106	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	167	56	F	Y	tTc/tAc	2.98	0.99	0	benign	0.12	neutral	1	neutral	2.64	neutral	-2.7	deleterious	-2.61	high_impact	3.92	0.74	neutral	0.63	neutral	4.16	23.80	deleterious	0.13	0.4	0.49	neutral	0.74	disease	0.46	neutral	0.5	neutral	0	0.12	neutral	0.94	deleterious	-2	neutral	0.28	neutral	0.06	medium_impact	1.96	high_impact	2.24	high_impact	0.58	0.8	60.69	10.14	0.55	P	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3473	3473	T	C	MI.11107	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	167	56	F	S	tTc/tCc	2.98	0.99	0	probably_damaging	0.94	neutral	0.47	neutral	2.66	neutral	-2.21	deleterious	-6.92	high_impact	4.62	0.65	neutral	0.73	neutral	4.19	23.80	deleterious	0.02	0.35	0.41	neutral	0.84	disease	0.56	disease	0.68	disease	4	0.94	neutral	0.27	neutral	2	deleterious	0.78	deleterious	-1.87	low_impact	0.25	medium_impact	2.85	high_impact	0.20	0.8	60.69	10.14	0.58	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3473	3473	T	G	MI.11108	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	167	56	F	C	tTc/tGc	2.98	0.99	0	probably_damaging	0.98	neutral	0.18	neutral	2.63	deleterious	-3.61	deleterious	-6.87	high_impact	4.62	0.72	neutral	0.57	neutral	4.04	23.70	deleterious	0.03	0.35	0.61	disease	0.83	disease	0.57	disease	0.67	disease	3	0.99	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-2.34	low_impact	-0.09	medium_impact	2.85	high_impact	0.21	0.8	60.69	10.14	0.63	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3474	3474	C	G	MI.11109	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	168	56	F	L	ttC/ttG	7.34	1	0	possibly_damaging	0.74	neutral	0.71	neutral	2.86	neutral	1.15	deleterious	-4.87	low_impact	1.66	0.68	neutral	0.58	neutral	4.21	23.90	deleterious	0.19	0.45	0.12	neutral	0.61	disease	0.26	neutral	0.41	neutral	2	0.69	neutral	0.49	deleterious	-3	neutral	0.59	deleterious	-1.18	low_impact	0.49	medium_impact	0.26	medium_impact	0.77	0.85	60.69	10.14	0.55	P	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9047	9047	T	G	MI.1111	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	521	174	I	S	aTt/aGt	5.68	1	0	probably_damaging	0.99	deleterious	0	neutral	4.16	neutral	-2.97	deleterious	-4.52	high_impact	3.98	0.79	neutral	0.58	neutral	4.36	24.10	deleterious	0.21	0.65	0.89	disease	0.77	disease	0.62	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.65	low_impact	-1.4	low_impact	2.31	high_impact	0.63	0.9	20.8	19.14	0.5	P	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3474	3474	C	A	MI.11110	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	168	56	F	L	ttC/ttA	7.34	1	0	possibly_damaging	0.74	neutral	0.71	neutral	2.86	neutral	1.15	deleterious	-4.87	low_impact	1.66	0.68	neutral	0.58	neutral	4.52	24.30	deleterious	0.19	0.45	0.12	neutral	0.61	disease	0.26	neutral	0.41	neutral	2	0.69	neutral	0.49	deleterious	-3	neutral	0.59	deleterious	-1.18	low_impact	0.49	medium_impact	0.26	medium_impact	0.77	0.85	60.69	10.14	0.55	P	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3475	3475	A	C	MI.11111	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	169	57	T	P	Acc/Ccc	-4.38	0	0	probably_damaging	0.93	neutral	0.28	neutral	2.71	neutral	-2.39	deleterious	-2.96	high_impact	3.98	0.58	damaging	0.1	damaging	3.42	23.00	deleterious	0.04	0.35	0.51	disease	0.8	disease	0.59	disease	0.73	disease	5	0.95	neutral	0.18	neutral	2	deleterious	0.76	deleterious	-1.81	low_impact	0.05	medium_impact	2.29	high_impact	0.34	0.8	13.21	19.45	0.35	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3475	3475	A	G	MI.11112	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	169	57	T	A	Acc/Gcc	-4.38	0	0	possibly_damaging	0.44	neutral	0.72	neutral	2.79	neutral	-0.17	neutral	-1.41	medium_impact	2.74	0.65	neutral	0.15	damaging	3.42	23.00	deleterious	0.27	0.45	0.24	neutral	0.33	neutral	0.34	neutral	0.45	neutral	1	0.34	neutral	0.64	deleterious	0	NA	0.28	neutral	-0.65	medium_impact	0.51	medium_impact	1.2	medium_impact	0.32	0.8	13.21	19.45	0.28	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3475	3475	A	T	MI.11113	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	169	57	T	S	Acc/Tcc	-4.38	0	0	possibly_damaging	0.71	neutral	0.6	neutral	2.76	neutral	-0.79	neutral	-1.74	low_impact	1.7	0.81	neutral	0.27	damaging	3.20	22.70	deleterious	0.31	0.45	0.21	neutral	0.41	neutral	0.18	neutral	0.45	neutral	1	0.66	neutral	0.45	neutral	-3	neutral	0.47	deleterious	-1.12	low_impact	0.37	medium_impact	0.3	medium_impact	0.56	0.8	13.21	19.45	0.38	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3476	3476	C	T	MI.11114	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	170	57	T	I	aCc/aTc	4.58	0.26	0	benign	0.04	neutral	0.45	neutral	2.89	neutral	0.8	neutral	1.28	neutral_impact	0.61	0.83	neutral	0.94	neutral	1.20	11.74	neutral	0.17	0.45	0.18	neutral	0.11	neutral	0.15	neutral	0.27	neutral	5	0.52	neutral	0.71	deleterious	-6	neutral	0.11	neutral	0.55	medium_impact	0.23	medium_impact	-0.66	medium_impact	0.67	0.85	13.21	19.45	0.48	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3476	3476	C	A	MI.11115	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	170	57	T	N	aCc/aAc	4.58	0.26	0	possibly_damaging	0.86	neutral	0.43	neutral	2.72	neutral	-1.85	deleterious	-2.67	low_impact	1.86	0.57	damaging	0.14	damaging	3.62	23.20	deleterious	0.33	0.5	0.37	neutral	0.71	disease	0.44	neutral	0.52	disease	0	0.85	neutral	0.29	neutral	-3	neutral	0.65	deleterious	-1.49	low_impact	0.21	medium_impact	0.44	medium_impact	0.66	0.8	13.21	19.45	0.37	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3476	3476	C	G	MI.11116	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	170	57	T	S	aCc/aGc	4.58	0.26	0	possibly_damaging	0.71	neutral	0.6	neutral	2.76	neutral	-0.79	neutral	-1.74	low_impact	1.7	0.81	neutral	0.27	damaging	3.41	23.00	deleterious	0.31	0.45	0.21	neutral	0.41	neutral	0.18	neutral	0.45	neutral	1	0.66	neutral	0.45	neutral	-3	neutral	0.47	deleterious	-1.12	low_impact	0.37	medium_impact	0.3	medium_impact	0.56	0.8	13.21	19.45	0.36	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3478	3478	A	C	MI.11117	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	172	58	K	Q	Aaa/Caa	-6.67	0	0	probably_damaging	1	neutral	0.59	neutral	1.81	deleterious	-4.95	deleterious	-3.63	high_impact	4.4	0.6	neutral	0.09	damaging	3.37	22.90	deleterious	0.1	0.4	0.62	disease	0.79	disease	0.7	disease	0.7	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.36	medium_impact	2.65	high_impact	0.33	0.8	59.75	10.72	0.38	N	0.92	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3478	3478	A	G	MI.11118	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	172	58	K	E	Aaa/Gaa	-6.67	0	0	probably_damaging	1	neutral	1	neutral	1.81	deleterious	-5.83	deleterious	-3.63	high_impact	4.6	0.68	neutral	0.08	damaging	3.95	23.60	deleterious	0.06	0.35	0.69	disease	0.77	disease	0.73	disease	0.74	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.84	deleterious	-3.57	low_impact	1.96	high_impact	2.83	high_impact	0.37	0.8	59.75	10.72	0.42	N	0.92	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3479	3479	A	C	MI.11119	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	173	58	K	T	aAa/aCa	8.49	1	0	probably_damaging	1	neutral	0.57	neutral	1.79	deleterious	-6.54	deleterious	-5.43	high_impact	4.95	0.6	damaging	0.08	damaging	3.55	23.10	deleterious	0.05	0.35	0.76	disease	0.76	disease	0.71	disease	0.73	disease	5	1	deleterious	0.29	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.34	medium_impact	3.13	high_impact	0.23	0.8	59.75	10.72	0.71	P	0.82	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9048	9048	T	G	MI.1112	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	522	174	I	M	atT/atG	4.76	1	0	probably_damaging	1	neutral	0.09	neutral	4.19	neutral	-2.11	neutral	-2.29	medium_impact	2.32	0.81	neutral	0.58	neutral	3.50	23.10	deleterious	0.39	0.65	0.7	disease	0.54	disease	0.55	disease	0.53	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.28	medium_impact	0.89	medium_impact	0.87	0.9	20.8	19.14	0.47	N	0.75	disease_causing	1	0.03	rs386829059	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3479	3479	A	T	MI.11120	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	173	58	K	M	aAa/aTa	8.49	1	0	probably_damaging	1	neutral	0.11	neutral	1.76	deleterious	-8.12	deleterious	-5.44	high_impact	4.6	0.66	neutral	0.07	damaging	3.92	23.50	deleterious	0.04	0.35	0.89	disease	0.79	disease	0.69	disease	0.77	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.23	medium_impact	2.83	high_impact	0.26	0.8	59.75	10.72	0.62	P	0.50	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3480	3480	A	C	MI.11121	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	174	58	K	N	aaA/aaC	8.49	1	0.06	probably_damaging	1	neutral	0.49	neutral	1.79	deleterious	-6.26	deleterious	-4.54	high_impact	4.4	0.62	neutral	0.07	damaging	3.73	23.30	deleterious	0.09	0.35	0.74	disease	0.8	disease	0.71	disease	0.73	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.27	medium_impact	2.65	high_impact	0.25	0.8	59.75	10.72	0.62	P	0.84	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3480	3480	A	T	MI.11122	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	174	58	K	N	aaA/aaT	8.49	1	0.06	probably_damaging	1	neutral	0.49	neutral	1.79	deleterious	-6.26	deleterious	-4.54	high_impact	4.4	0.62	neutral	0.07	damaging	3.82	23.40	deleterious	0.09	0.35	0.74	disease	0.8	disease	0.71	disease	0.73	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.27	medium_impact	2.65	high_impact	0.25	0.8	59.75	10.72	0.63	P	0.84	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3481	3481	G	C	MI.11123	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	175	59	E	Q	Gag/Cag	4.58	1	0	probably_damaging	1	neutral	0.58	neutral	1.75	deleterious	-5.04	deleterious	-2.73	high_impact	3.54	0.68	neutral	0.13	damaging	3.30	22.90	deleterious	0.43	0.55	0.32	neutral	0.79	disease	0.62	disease	0.68	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.35	medium_impact	1.9	medium_impact	0.49	0.8	58.49	10.43	0.53	N	0.91	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3481	3481	G	A	MI.11124	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	175	59	E	K	Gag/Aag	4.58	1	0	probably_damaging	1	neutral	0.95	neutral	1.77	deleterious	-4.61	deleterious	-3.63	high_impact	3.62	0.67	neutral	0.09	damaging	4.44	24.20	deleterious	0.13	0.4	0.34	neutral	0.87	disease	0.77	disease	0.76	disease	5	1	deleterious	0.48	deleterious	2	deleterious	0.84	deleterious	-3.57	low_impact	0.99	medium_impact	1.97	medium_impact	0.67	0.85	58.49	10.43	0.69	P	0.99	disease_causing_automatic	0	0.31	rs587776433	Pathogenic	Leigh_syndrome	165629	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	.	.	G3481A	Progressive Encephalomyopathy	-	+	Reported	1	P	P	P	damaging
chrM	3482	3482	A	C	MI.11125	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	176	59	E	A	gAg/gCg	7.11	1	0	probably_damaging	1	neutral	0.75	neutral	1.75	deleterious	-4.91	deleterious	-5.44	high_impact	4.05	0.69	neutral	0.14	damaging	3.50	23.10	deleterious	0.12	0.4	0.4	neutral	0.65	disease	0.74	disease	0.72	disease	4	1	deleterious	0.38	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.54	medium_impact	2.35	high_impact	0.36	0.8	58.49	10.43	0.58	P	0.74	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3482	3482	A	G	MI.11126	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	176	59	E	G	gAg/gGg	7.11	1	0	probably_damaging	1	neutral	0.38	neutral	1.74	deleterious	-5.26	deleterious	-6.36	high_impact	3.88	0.68	neutral	0.14	damaging	4.05	23.70	deleterious	0.13	0.4	0.48	neutral	0.8	disease	0.72	disease	0.72	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.16	medium_impact	2.2	high_impact	0.21	0.8	58.49	10.43	0.62	P	0.61	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3482	3482	A	T	MI.11127	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	176	59	E	V	gAg/gTg	7.11	1	0	probably_damaging	1	neutral	0.3	neutral	1.73	deleterious	-5.97	deleterious	-6.36	high_impact	4.05	0.63	neutral	0.11	damaging	4.07	23.70	deleterious	0.09	0.35	0.58	disease	0.86	disease	0.75	disease	0.78	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.07	medium_impact	2.35	high_impact	0.26	0.8	58.49	10.43	0.64	P	0.83	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3483	3483	G	C	MI.11128	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	177	59	E	D	gaG/gaC	8.49	1	0.01	probably_damaging	1	neutral	0.62	neutral	1.8	deleterious	-3.99	deleterious	-2.72	high_impact	4.17	0.77	neutral	0.14	damaging	3.60	23.20	deleterious	0.38	0.5	0.41	neutral	0.75	disease	0.68	disease	0.68	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.39	medium_impact	2.45	high_impact	0.48	0.8	58.49	10.43	0.57	P	0.90	polymorphism	0.98	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3483	3483	G	T	MI.11129	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	177	59	E	D	gaG/gaT	8.49	1	0.01	probably_damaging	1	neutral	0.62	neutral	1.8	deleterious	-3.99	deleterious	-2.72	high_impact	4.17	0.77	neutral	0.14	damaging	3.76	23.30	deleterious	0.38	0.5	0.41	neutral	0.75	disease	0.68	disease	0.68	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.39	medium_impact	2.45	high_impact	0.48	0.8	58.49	10.43	0.57	P	0.90	polymorphism	0.98	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9048	9048	T	A	MI.1113	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	522	174	I	M	atT/atA	4.76	1	0	probably_damaging	1	neutral	0.09	neutral	4.19	neutral	-2.11	neutral	-2.29	medium_impact	2.32	0.81	neutral	0.58	neutral	3.75	23.30	deleterious	0.39	0.65	0.7	disease	0.54	disease	0.55	disease	0.53	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.28	medium_impact	0.89	medium_impact	0.87	0.9	20.8	19.14	0.49	P	0.75	disease_causing	1	0.03	rs386829059	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3484	3484	C	T	MI.11130	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	178	60	P	S	Ccc/Tcc	-0.93	0.01	0	probably_damaging	1	neutral	0.73	neutral	2.8	neutral	1.21	deleterious	-7.35	medium_impact	2.44	0.78	neutral	0.13	damaging	3.79	23.40	deleterious	0.27	0.45	0.17	neutral	0.64	disease	0.22	neutral	0.46	neutral	1	1	deleterious	0.37	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.52	medium_impact	0.94	medium_impact	0.21	0.8	57.55	10.26	0.25	N	0.74	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3484	3484	C	A	MI.11131	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	178	60	P	T	Ccc/Acc	-0.93	0.01	0	probably_damaging	1	neutral	0.58	neutral	2.8	neutral	0.89	deleterious	-7.35	low_impact	1.88	0.66	neutral	0.1	damaging	3.75	23.30	deleterious	0.26	0.45	0.21	neutral	0.53	disease	0.2	neutral	0.42	neutral	2	1	deleterious	0.29	neutral	-2	neutral	0.69	deleterious	-3.57	low_impact	0.35	medium_impact	0.45	medium_impact	0.41	0.8	57.55	10.26	0.26	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3484	3484	C	G	MI.11132	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	178	60	P	A	Ccc/Gcc	-0.93	0.01	0	probably_damaging	1	neutral	0.75	neutral	2.8	neutral	0.48	deleterious	-7.35	medium_impact	3.27	0.72	neutral	0.14	damaging	2.99	22.20	deleterious	0.27	0.45	0.17	neutral	0.35	neutral	0.43	neutral	0.42	neutral	2	1	deleterious	0.38	neutral	1	deleterious	0.68	deleterious	-3.57	low_impact	0.54	medium_impact	1.67	medium_impact	0.55	0.8	57.55	10.26	0.29	N	0.78	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3485	3485	C	A	MI.11133	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	179	60	P	H	cCc/cAc	5.5	1	0	probably_damaging	1	neutral	0.14	neutral	2.74	neutral	-0.93	deleterious	-8.27	medium_impact	3.27	0.72	neutral	0.1	damaging	3.91	23.50	deleterious	0.13	0.4	0.37	neutral	0.67	disease	0.31	neutral	0.48	neutral	0	1	deleterious	0.07	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	-0.17	medium_impact	1.67	medium_impact	0.23	0.8	57.55	10.26	0.55	P	0.69	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3485	3485	C	G	MI.11134	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	179	60	P	R	cCc/cGc	5.5	1	0	probably_damaging	1	neutral	0.52	neutral	2.78	neutral	0.37	deleterious	-8.27	medium_impact	3.4	0.76	neutral	0.1	damaging	3.50	23.10	deleterious	0.15	0.4	0.23	neutral	0.79	disease	0.52	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.29	medium_impact	1.78	medium_impact	0.28	0.8	57.55	10.26	0.44	N	0.71	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3485	3485	C	T	MI.11135	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	179	60	P	L	cCc/cTc	5.5	1	0	probably_damaging	1	neutral	0.36	neutral	2.76	neutral	-0.1	deleterious	-9.19	low_impact	1.86	0.71	neutral	0.08	damaging	4.36	24.10	deleterious	0.18	0.45	0.31	neutral	0.68	disease	0.33	neutral	0.46	neutral	1	1	deleterious	0.18	neutral	-2	neutral	0.72	deleterious	-3.57	low_impact	0.14	medium_impact	0.44	medium_impact	0.43	0.8	57.55	10.26	0.47	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3487	3487	C	A	MI.11136	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	181	61	L	M	Cta/Ata	-12.88	0	0	possibly_damaging	0.52	neutral	0.29	neutral	2.67	neutral	-1.75	neutral	-0.79	low_impact	1.07	0.82	neutral	0.9	neutral	2.59	20.10	deleterious	0.25	0.45	0.23	neutral	0.26	neutral	0.15	neutral	0.45	neutral	1	0.69	neutral	0.39	neutral	-3	neutral	0.31	neutral	-0.78	medium_impact	0.06	medium_impact	-0.25	medium_impact	0.50	0.8	18.24	23.26	0.52	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3487	3487	C	G	MI.11137	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	181	61	L	V	Cta/Gta	-12.88	0	0	possibly_damaging	0.74	neutral	0.47	neutral	2.83	neutral	0.47	neutral	0.51	neutral_impact	0.13	0.85	neutral	0.72	neutral	0.84	9.70	deleterious	0.24	0.45	0.13	neutral	0.08	neutral	0.11	neutral	0.24	neutral	5	0.73	neutral	0.37	neutral	-3	neutral	0.48	deleterious	-1.18	low_impact	0.25	medium_impact	-1.08	low_impact	0.29	0.8	18.24	23.26	0.45	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3488	3488	T	A	MI.11138	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	182	61	L	Q	cTa/cAa	-2.08	0	0	probably_damaging	0.96	neutral	0.29	neutral	2.61	deleterious	-3.35	deleterious	-4.12	medium_impact	3.24	0.72	neutral	0.45	neutral	4.01	23.60	deleterious	0.07	0.35	0.54	disease	0.59	disease	0.46	neutral	0.51	disease	0	0.96	neutral	0.17	neutral	1	deleterious	0.71	deleterious	-2.05	low_impact	0.06	medium_impact	1.64	medium_impact	0.10	0.8	18.24	23.26	0.42	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3488	3488	T	C	MI.11139	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	182	61	L	P	cTa/cCa	-2.08	0	0	probably_damaging	0.96	neutral	0.22	neutral	2.61	deleterious	-3.39	deleterious	-4.41	medium_impact	2.69	0.64	neutral	0.34	neutral	3.84	23.40	deleterious	0.05	0.35	0.6	disease	0.78	disease	0.47	neutral	0.67	disease	3	0.97	neutral	0.13	neutral	1	deleterious	0.81	deleterious	-2.05	low_impact	-0.03	medium_impact	1.16	medium_impact	0.14	0.8	18.24	23.26	0.34	N	0.87	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	T3488C	LHON	+	-	Reported	1	.	P	P	neutral
chrM	9049	9049	G	C	MI.1114	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	523	175	G	R	Gga/Cga	-6.12	0	0	probably_damaging	1	deleterious	0.01	neutral	4.32	deleterious	-3.06	deleterious	-4.68	medium_impact	2.46	0.82	neutral	0.06	damaging	3.98	23.60	deleterious	0.12	0.65	0.53	disease	0.9	disease	0.74	disease	0.82	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	1.01	medium_impact	0.70	0.9	44.25	8.03	0.24	N	0.98	polymorphism	0.78	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3488	3488	T	G	MI.11140	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	182	61	L	R	cTa/cGa	-2.08	0	0	probably_damaging	0.94	neutral	0.31	neutral	2.61	deleterious	-3.04	deleterious	-4.45	medium_impact	2.69	0.67	neutral	0.41	neutral	4.09	23.70	deleterious	0.05	0.35	0.51	disease	0.77	disease	0.55	disease	0.75	disease	5	0.95	neutral	0.19	neutral	1	deleterious	0.77	deleterious	-1.87	low_impact	0.08	medium_impact	1.16	medium_impact	0.12	0.8	18.24	23.26	0.32	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3490	3490	A	G	MI.11141	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	184	62	K	E	Aaa/Gaa	-3	0	0	benign	0.18	neutral	1	neutral	2.77	neutral	-0.79	neutral	-1.36	medium_impact	1.95	0.84	neutral	0.7	neutral	3.92	23.50	deleterious	0.26	0.45	0.24	neutral	0.64	disease	0.43	neutral	0.5	disease	0	0.18	neutral	0.91	deleterious	-3	neutral	0.27	neutral	-0.13	medium_impact	1.96	high_impact	0.52	medium_impact	0.42	0.8	26.73	39.85	0.25	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3490	3490	A	C	MI.11142	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	184	62	K	Q	Aaa/Caa	-3	0	0	benign	0.02	neutral	0.59	neutral	2.76	neutral	-0.67	neutral	-0.29	low_impact	1.32	0.82	neutral	0.97	neutral	2.20	17.49	deleterious	0.39	0.5	0.27	neutral	0.33	neutral	0.25	neutral	0.44	neutral	1	0.38	neutral	0.79	deleterious	-6	neutral	0.16	neutral	0.84	medium_impact	0.36	medium_impact	-0.04	medium_impact	0.36	0.8	26.73	39.85	0.36	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3491	3491	A	C	MI.11143	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	185	62	K	T	aAa/aCa	0.22	0	0	benign	0.41	neutral	0.59	neutral	2.81	neutral	1.17	deleterious	-2.5	neutral_impact	0.55	0.69	neutral	0.66	neutral	3.51	23.10	deleterious	0.14	0.4	0.16	neutral	0.37	neutral	0.38	neutral	0.43	neutral	1	0.37	neutral	0.59	deleterious	-6	neutral	0.37	neutral	-0.6	medium_impact	0.36	medium_impact	-0.71	medium_impact	0.20	0.8	26.73	39.85	0.3	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3491	3491	A	T	MI.11144	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	185	62	K	M	aAa/aTa	0.22	0	0	possibly_damaging	0.58	neutral	0.12	neutral	2.74	neutral	-0.08	neutral	-2.33	low_impact	1.05	0.71	neutral	0.61	neutral	3.74	23.30	deleterious	0.12	0.4	0.3	neutral	0.45	neutral	0.28	neutral	0.49	neutral	0	0.88	neutral	0.27	neutral	-3	neutral	0.50	deleterious	-0.88	medium_impact	-0.21	medium_impact	-0.27	medium_impact	0.19	0.8	26.73	39.85	0.41	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3492	3492	A	T	MI.11145	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	186	62	K	N	aaA/aaT	0.45	0	0	benign	0.26	neutral	0.51	neutral	2.75	neutral	-1.09	neutral	-1.59	low_impact	1.29	0.68	neutral	0.67	neutral	3.82	23.40	deleterious	0.5	0.6	0.3	neutral	0.52	disease	0.28	neutral	0.5	disease	0	0.39	neutral	0.63	deleterious	-6	neutral	0.38	neutral	-0.32	medium_impact	0.29	medium_impact	-0.06	medium_impact	0.34	0.8	26.73	39.85	0.38	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3492	3492	A	C	MI.11146	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	186	62	K	N	aaA/aaC	0.45	0	0	benign	0.26	neutral	0.51	neutral	2.75	neutral	-1.09	neutral	-1.59	low_impact	1.29	0.68	neutral	0.67	neutral	3.75	23.30	deleterious	0.5	0.6	0.3	neutral	0.52	disease	0.28	neutral	0.5	disease	0	0.39	neutral	0.63	deleterious	-6	neutral	0.38	neutral	-0.32	medium_impact	0.29	medium_impact	-0.06	medium_impact	0.34	0.8	26.73	39.85	0.38	N	0.59	polymorphism	1	0.02	rs878950749	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3493	3493	C	G	MI.11147	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	187	63	P	A	Ccc/Gcc	-5.07	0	0	probably_damaging	1	neutral	0.87	neutral	1.22	deleterious	-5.75	deleterious	-7.38	high_impact	4.07	0.71	neutral	0.13	damaging	3.04	22.40	deleterious	0.15	0.4	0.43	neutral	0.57	disease	0.65	disease	0.65	disease	3	1	deleterious	0.44	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.74	medium_impact	2.37	high_impact	0.51	0.8	60.06	10.55	0.28	N	0.78	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3493	3493	C	A	MI.11148	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	187	63	P	T	Ccc/Acc	-5.07	0	0	probably_damaging	1	neutral	0.68	neutral	1.19	deleterious	-6.45	deleterious	-7.38	high_impact	3.87	0.77	neutral	0.11	damaging	3.79	23.40	deleterious	0.16	0.45	0.53	disease	0.77	disease	0.56	disease	0.66	disease	3	1	deleterious	0.34	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.46	medium_impact	2.19	high_impact	0.38	0.8	60.06	10.55	0.26	N	0.91	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3493	3493	C	T	MI.11149	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	187	63	P	S	Ccc/Tcc	-5.07	0	0	probably_damaging	1	neutral	0.76	neutral	1.21	deleterious	-6.02	deleterious	-7.38	medium_impact	3.13	0.73	neutral	0.12	damaging	3.78	23.40	deleterious	0.19	0.45	0.36	neutral	0.81	disease	0.57	disease	0.67	disease	3	1	deleterious	0.38	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	0.56	medium_impact	1.55	medium_impact	0.05	0.8	60.06	10.55	0.27	N	0.74	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9049	9049	G	T	MI.1115	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	523	175	G	W	Gga/Tga	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	4.29	deleterious	-4.73	deleterious	-5.34	medium_impact	3.01	0.87	neutral	0.07	damaging	4.46	24.20	deleterious	0.13	0.65	0.91	disease	0.9	disease	0.67	disease	0.82	disease	6	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	1.48	medium_impact	0.41	0.9	44.25	8.03	0.28	N	0.99	polymorphism	0.69	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3494	3494	C	T	MI.11150	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	188	63	P	L	cCc/cTc	5.5	0.99	0	probably_damaging	1	neutral	0.79	neutral	1.19	deleterious	-6.82	deleterious	-9.22	medium_impact	2.54	0.68	neutral	0.09	damaging	4.23	23.90	deleterious	0.11	0.4	0.49	neutral	0.84	disease	0.58	disease	0.51	disease	0	1	deleterious	0.4	neutral	1	deleterious	0.81	deleterious	-3.57	low_impact	0.6	medium_impact	1.03	medium_impact	0.67	0.85	60.06	10.55	0.43	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3494	3494	C	A	MI.11151	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	188	63	P	H	cCc/cAc	5.5	0.99	0	probably_damaging	1	neutral	0.59	neutral	1.17	deleterious	-8.08	deleterious	-8.3	high_impact	4.42	0.69	neutral	0.1	damaging	4.03	23.60	deleterious	0.09	0.35	0.79	disease	0.82	disease	0.71	disease	0.75	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.36	medium_impact	2.67	high_impact	0.22	0.8	60.06	10.55	0.58	P	0.69	polymorphism	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3494	3494	C	G	MI.11152	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	188	63	P	R	cCc/cGc	5.5	0.99	0	probably_damaging	1	neutral	0.6	neutral	1.18	deleterious	-6.98	deleterious	-8.3	high_impact	4.76	0.74	neutral	0.1	damaging	3.53	23.10	deleterious	0.06	0.35	0.67	disease	0.87	disease	0.72	disease	0.77	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.37	medium_impact	2.97	high_impact	0.25	0.8	60.06	10.55	0.71	P	0.71	polymorphism	0.99	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3496	3496	G	A	MI.11153	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	190	64	A	T	Gcc/Acc	-9.89	0	0.02	benign	0	neutral	0.72	neutral	2.71	neutral	-0.92	neutral	0.01	neutral_impact	-0.51	0.76	neutral	0.74	neutral	0.90	10.05	neutral	0.34	0.5	0.18	neutral	0.17	neutral	0.14	neutral	0.28	neutral	4	0.28	neutral	0.86	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.51	medium_impact	-1.63	low_impact	0.55	0.8	25.16	39.11	0.46	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	COSM5653110	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3496	3496	G	T	MI.11154	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	190	64	A	S	Gcc/Tcc	-9.89	0	0.02	benign	0	neutral	0.81	neutral	2.79	neutral	-0.3	neutral	1.31	neutral_impact	-0.84	0.68	neutral	0.95	neutral	-1.03	0.01	neutral	0.42	0.55	0.13	neutral	0.06	neutral	0.11	neutral	0.21	neutral	6	0.19	neutral	0.91	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.63	medium_impact	-1.92	low_impact	0.39	0.8	25.16	39.11	0.44	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	G3496T	LHON	+	-	Reported / Secondary	2	.	N	N	neutral
chrM	3496	3496	G	C	MI.11155	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	190	64	A	P	Gcc/Ccc	-9.89	0	0.02	benign	0.11	neutral	0.35	neutral	2.65	neutral	-2.44	neutral	-1.97	low_impact	1.13	0.67	neutral	0.37	neutral	0.76	9.24	deleterious	0.17	0.45	0.29	neutral	0.77	disease	0.28	neutral	0.58	disease	1	0.6	neutral	0.62	deleterious	-6	neutral	0.26	neutral	0.1	medium_impact	0.12	medium_impact	-0.2	medium_impact	0.37	0.8	25.16	39.11	0.38	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3497	3497	C	T	MI.11156	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	191	64	A	V	gCc/gTc	-2.08	0	0.07	benign	0.01	neutral	0.49	neutral	2.71	neutral	-2.06	neutral	-1.4	low_impact	1.36	0.75	neutral	0.71	neutral	1.25	11.99	neutral	0.27	0.45	0.16	neutral	0.37	neutral	0.17	neutral	0.44	neutral	1	0.49	neutral	0.74	deleterious	-6	neutral	0.12	neutral	1.12	medium_impact	0.27	medium_impact	0	medium_impact	0.47	0.8	25.16	39.11	0.44	N	0.45	polymorphism	1	0.02	rs200319905	.	.	.	.	.	.	.	.	C3497T	LHON	+	-	Reported / Secondary	3	N	N	N	neutral
chrM	3497	3497	C	A	MI.11157	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	191	64	A	D	gCc/gAc	-2.08	0	0.07	benign	0.06	neutral	0.61	neutral	2.7	neutral	-1.26	neutral	-1.71	low_impact	1.34	0.73	neutral	0.41	neutral	1.42	12.87	neutral	0.15	0.4	0.22	neutral	0.7	disease	0.37	neutral	0.48	neutral	0	0.32	neutral	0.78	deleterious	-6	neutral	0.18	neutral	0.37	medium_impact	0.38	medium_impact	-0.02	medium_impact	0.17	0.8	25.16	39.11	0.29	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3497	3497	C	G	MI.11158	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	191	64	A	G	gCc/gGc	-2.08	0	0.07	benign	0.04	neutral	0.47	neutral	2.67	neutral	-1.52	neutral	-1.65	low_impact	1.44	0.68	neutral	0.54	neutral	0.82	9.59	deleterious	0.39	0.5	0.32	neutral	0.42	neutral	0.25	neutral	0.47	neutral	1	0.49	neutral	0.72	deleterious	-6	neutral	0.14	neutral	0.55	medium_impact	0.25	medium_impact	0.07	medium_impact	0.52	0.8	25.16	39.11	0.44	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3499	3499	A	C	MI.11159	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	193	65	T	P	Aca/Cca	-5.52	0	0	probably_damaging	0.91	neutral	0.47	neutral	2.7	neutral	-2.18	deleterious	-4.06	medium_impact	2.38	0.74	neutral	0.15	damaging	3.37	22.90	deleterious	0.08	0.35	0.44	neutral	0.79	disease	0.35	neutral	0.6	disease	2	0.9	neutral	0.28	neutral	1	deleterious	0.73	deleterious	-1.69	low_impact	0.25	medium_impact	0.89	medium_impact	0.40	0.8	30.5	9.69	0.27	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9050	9050	G	A	MI.1116	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	524	175	G	E	gGa/gAa	2.44	0.99	0	probably_damaging	1	deleterious	0.03	neutral	4.34	deleterious	-3.05	deleterious	-4.46	medium_impact	2.12	0.86	neutral	0.08	damaging	3.94	23.50	deleterious	0.17	0.65	0.43	neutral	0.88	disease	0.73	disease	0.8	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.81	deleterious	-3.6	low_impact	-0.56	medium_impact	0.72	medium_impact	0.69	0.9	44.25	8.03	0.34	N	1.00	disease_causing	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3499	3499	A	G	MI.11160	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	193	65	T	A	Aca/Gca	-5.52	0	0	benign	0.05	neutral	0.71	neutral	2.78	neutral	-0.1	deleterious	-3.19	medium_impact	2.11	0.83	neutral	0.74	neutral	2.26	17.93	deleterious	0.25	0.45	0.2	neutral	0.29	neutral	0.34	neutral	0.43	neutral	1	0.21	neutral	0.83	deleterious	-3	neutral	0.13	neutral	0.45	medium_impact	0.49	medium_impact	0.65	medium_impact	0.27	0.8	30.5	9.69	0.3	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3499	3499	A	T	MI.11161	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	193	65	T	S	Aca/Tca	-5.52	0	0	benign	0.13	neutral	0.72	neutral	2.81	neutral	-0.26	neutral	-1.98	low_impact	0.82	0.81	neutral	0.66	neutral	1.96	15.95	deleterious	0.42	0.55	0.18	neutral	0.36	neutral	0.22	neutral	0.44	neutral	1	0.16	neutral	0.8	deleterious	-6	neutral	0.17	neutral	0.02	medium_impact	0.51	medium_impact	-0.47	medium_impact	0.48	0.8	30.5	9.69	0.3	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3500	3500	C	T	MI.11162	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	194	65	T	M	aCa/aTa	2.98	0.72	0	probably_damaging	0.95	neutral	0.17	neutral	2.71	neutral	-2.68	deleterious	-4.09	low_impact	1.78	0.77	neutral	0.16	damaging	3.96	23.60	deleterious	0.2	0.45	0.45	neutral	0.41	neutral	0.25	neutral	0.47	neutral	1	0.97	neutral	0.11	neutral	-2	neutral	0.65	deleterious	-1.95	low_impact	-0.11	medium_impact	0.37	medium_impact	0.35	0.8	30.5	9.69	0.34	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3500	3500	C	A	MI.11163	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	194	65	T	K	aCa/aAa	2.98	0.72	0	possibly_damaging	0.76	neutral	0.92	neutral	2.82	neutral	0.17	deleterious	-3.83	low_impact	1.4	0.69	neutral	0.11	damaging	4.43	24.20	deleterious	0.13	0.4	0.17	neutral	0.71	disease	0.43	neutral	0.52	disease	0	0.73	neutral	0.58	deleterious	-3	neutral	0.61	deleterious	-1.22	low_impact	0.87	medium_impact	0.03	medium_impact	0.38	0.8	30.5	9.69	0.28	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3502	3502	T	C	MI.11164	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	196	66	S	P	Tct/Cct	-3.92	0	0	probably_damaging	1	neutral	0.52	neutral	2.44	deleterious	-3.82	deleterious	-4.09	high_impact	4.21	0.68	neutral	0.13	damaging	3.88	23.50	deleterious	0.07	0.35	0.71	disease	0.74	disease	0.69	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.29	medium_impact	2.49	high_impact	0.08	0.8	16.67	30.3	0.36	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3502	3502	T	A	MI.11165	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	196	66	S	T	Tct/Act	-3.92	0	0	probably_damaging	1	neutral	0.74	neutral	2.5	neutral	-2.31	neutral	-2.24	medium_impact	3.21	0.84	neutral	0.76	neutral	2.63	20.40	deleterious	0.36	0.5	0.42	neutral	0.45	neutral	0.59	disease	0.45	neutral	1	1	deleterious	0.37	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.53	medium_impact	1.62	medium_impact	0.48	0.8	16.67	30.3	0.34	N	0.08	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3502	3502	T	G	MI.11166	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	196	66	S	A	Tct/Gct	-3.92	0	0	probably_damaging	1	neutral	0.84	neutral	2.75	neutral	-0.27	neutral	-1.84	low_impact	1.25	0.88	neutral	0.81	neutral	2.38	18.69	deleterious	0.44	0.55	0.16	neutral	0.08	neutral	0.35	neutral	0.27	neutral	5	1	deleterious	0.42	neutral	-2	neutral	0.66	deleterious	-3.57	low_impact	0.68	medium_impact	-0.1	medium_impact	0.29	0.8	16.67	30.3	0.35	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3503	3503	C	T	MI.11167	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	197	66	S	F	tCt/tTt	1.6	0.95	0	probably_damaging	1	neutral	0.43	neutral	2.42	deleterious	-4.58	deleterious	-5.02	medium_impact	3.36	0.59	damaging	0.1	damaging	4.07	23.70	deleterious	0.06	0.35	0.83	disease	0.72	disease	0.73	disease	0.76	disease	5	1	deleterious	0.22	neutral	1	deleterious	0.82	deleterious	-3.57	low_impact	0.21	medium_impact	1.75	medium_impact	0.02	0.8	16.67	30.3	0.43	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3503	3503	C	G	MI.11168	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	197	66	S	C	tCt/tGt	1.6	0.95	0	probably_damaging	1	neutral	0.13	neutral	2.42	deleterious	-4.52	deleterious	-3.95	high_impact	4.21	0.69	neutral	0.12	damaging	3.46	23.00	deleterious	0.07	0.35	0.78	disease	0.61	disease	0.68	disease	0.68	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.19	medium_impact	2.49	high_impact	0.11	0.8	16.67	30.3	0.53	P	0.50	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3503	3503	C	A	MI.11169	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	197	66	S	Y	tCt/tAt	1.6	0.95	0	probably_damaging	1	neutral	0.66	neutral	2.42	deleterious	-4.76	deleterious	-5.02	high_impact	3.66	0.73	neutral	0.13	damaging	4.07	23.70	deleterious	0.06	0.35	0.85	disease	0.69	disease	0.68	disease	0.74	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.44	medium_impact	2.01	high_impact	0.06	0.8	16.67	30.3	0.44	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9050	9050	G	T	MI.1117	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	524	175	G	V	gGa/gTa	2.44	0.99	0	probably_damaging	1	deleterious	0.01	neutral	4.43	neutral	-1.2	deleterious	-5.33	medium_impact	2.12	0.86	neutral	0.09	damaging	3.81	23.40	deleterious	0.18	0.65	0.36	neutral	0.83	disease	0.63	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.74	deleterious	-3.6	low_impact	-0.84	medium_impact	0.72	medium_impact	0.56	0.9	44.25	8.03	0.33	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3505	3505	A	T	MI.11170	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	199	67	T	S	Acc/Tcc	-7.59	0	0.04	benign	0.04	neutral	0.95	neutral	2.98	neutral	1.77	neutral	2.53	neutral_impact	-2.42	0.61	neutral	0.85	neutral	1.03	10.82	neutral	0.43	0.55	0.18	neutral	0.03	neutral	0.16	neutral	0.23	neutral	5	0.01	neutral	0.96	deleterious	-6	neutral	0.10	neutral	0.55	medium_impact	0.99	medium_impact	-3.3	low_impact	0.38	0.8	23.58	35.6	0.42	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3505	3505	A	C	MI.11171	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	199	67	T	P	Acc/Ccc	-7.59	0	0.04	possibly_damaging	0.75	neutral	0.44	neutral	2.76	neutral	-1.41	neutral	-1.97	low_impact	1.65	0.55	damaging	0.47	neutral	3.90	23.50	deleterious	0.09	0.35	0.22	neutral	0.7	disease	0.56	disease	0.68	disease	4	0.75	neutral	0.35	neutral	-3	neutral	0.66	deleterious	-1.2	low_impact	0.22	medium_impact	0.25	medium_impact	0.28	0.8	23.58	35.6	0.36	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3505	3505	A	G	MI.11172	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	199	67	T	A	Acc/Gcc	-7.59	0	0.04	benign	0.01	neutral	1	neutral	2.82	neutral	0.2	neutral	-0.14	neutral_impact	0.45	0.67	neutral	0.89	neutral	3.88	23.50	deleterious	0.32	0.5	0.15	neutral	0.17	neutral	0.32	neutral	0.31	neutral	4	0.01	neutral	1	deleterious	-6	neutral	0.12	neutral	1.12	medium_impact	1.96	high_impact	-0.8	medium_impact	0.28	0.8	23.58	35.6	0.31	N	0.18	polymorphism	1	0.01	rs28358585	Benign	not_specified	247211	MedGen:CN169374	pancreatic cancer cell line, prostate tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3506	3506	C	G	MI.11173	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	200	67	T	S	aCc/aGc	2.98	0.98	0	benign	0.04	neutral	0.95	neutral	2.98	neutral	1.77	neutral	2.53	neutral_impact	-2.42	0.61	neutral	0.85	neutral	0.70	8.81	deleterious	0.43	0.55	0.18	neutral	0.03	neutral	0.16	neutral	0.23	neutral	5	0.01	neutral	0.96	deleterious	-6	neutral	0.10	neutral	0.55	medium_impact	0.99	medium_impact	-3.3	low_impact	0.38	0.8	23.58	35.6	0.46	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3506	3506	C	A	MI.11174	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	200	67	T	N	aCc/aAc	2.98	0.98	0	possibly_damaging	0.61	neutral	0.65	neutral	2.89	neutral	1.03	neutral	-0.18	neutral_impact	-1.29	0.58	damaging	0.66	neutral	3.55	23.10	deleterious	0.43	0.55	0.14	neutral	0.21	neutral	0.22	neutral	0.34	neutral	3	0.54	neutral	0.52	deleterious	-3	neutral	0.36	neutral	-0.93	medium_impact	0.43	medium_impact	-2.32	low_impact	0.46	0.8	23.58	35.6	0.48	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3506	3506	C	T	MI.11175	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	200	67	T	I	aCc/aTc	2.98	0.98	0	possibly_damaging	0.61	neutral	0.52	neutral	2.75	neutral	-1.76	deleterious	-2.84	low_impact	0.84	0.55	damaging	0.62	neutral	3.88	23.50	deleterious	0.19	0.45	0.36	neutral	0.34	neutral	0.56	disease	0.47	neutral	1	0.58	neutral	0.46	neutral	-3	neutral	0.41	neutral	-0.93	medium_impact	0.29	medium_impact	-0.46	medium_impact	0.42	0.8	23.58	35.6	0.53	P	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3508	3508	A	C	MI.11176	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	202	68	I	L	Atc/Ctc	-10.81	0	0	benign	0.05	neutral	0.6	neutral	2.8	neutral	0.16	neutral	0.04	neutral_impact	-0.67	0.86	neutral	0.94	neutral	0.62	8.32	deleterious	0.29	0.45	0.19	neutral	0.26	neutral	0.34	neutral	0.41	neutral	2	0.34	neutral	0.78	deleterious	-6	neutral	0.13	neutral	0.45	medium_impact	0.37	medium_impact	-1.77	low_impact	0.52	0.8	20.75	15.63	0.29	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3508	3508	A	G	MI.11177	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	202	68	I	V	Atc/Gtc	-10.81	0	0	benign	0.05	neutral	0.49	neutral	2.8	neutral	-0.02	neutral	0.5	neutral_impact	-0.14	0.83	neutral	0.91	neutral	-0.04	2.24	deleterious	0.31	0.45	0.2	neutral	0.16	neutral	0.36	neutral	0.3	neutral	4	0.46	neutral	0.72	deleterious	-6	neutral	0.12	neutral	0.45	medium_impact	0.27	medium_impact	-1.31	low_impact	0.44	0.8	20.75	15.63	0.35	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3508	3508	A	T	MI.11178	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	202	68	I	F	Atc/Ttc	-10.81	0	0	possibly_damaging	0.49	neutral	0.36	neutral	2.76	neutral	-0.86	neutral	-1.15	neutral_impact	-0.58	0.85	neutral	0.61	neutral	1.94	15.82	deleterious	0.17	0.45	0.19	neutral	0.37	neutral	0.26	neutral	0.44	neutral	1	0.61	neutral	0.44	neutral	-3	neutral	0.32	neutral	-0.74	medium_impact	0.14	medium_impact	-1.7	low_impact	0.49	0.8	20.75	15.63	0.37	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3509	3509	T	A	MI.11179	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	203	68	I	N	aTc/aAc	0.22	0	0	benign	0.11	neutral	0.63	neutral	2.79	neutral	0.1	neutral	-0.15	neutral_impact	0.43	0.84	neutral	0.71	neutral	2.34	18.41	deleterious	0.14	0.4	0.26	neutral	0.64	disease	0.45	neutral	0.51	disease	0	0.27	neutral	0.76	deleterious	-6	neutral	0.19	neutral	0.1	medium_impact	0.4	medium_impact	-0.81	medium_impact	0.20	0.8	20.75	15.63	0.25	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9050	9050	G	C	MI.1118	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	524	175	G	A	gGa/gCa	2.44	0.99	0	probably_damaging	1	neutral	0.62	neutral	4.59	neutral	0.16	deleterious	-2.53	neutral_impact	-0.12	0.82	neutral	0.39	neutral	0.83	9.64	deleterious	0.41	0.65	0.29	neutral	0.28	neutral	0.35	neutral	0.43	neutral	1	1	deleterious	0.31	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.41	medium_impact	-1.2	low_impact	0.72	0.9	44.25	8.03	0.3	N	0.79	disease_causing	0.88	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3509	3509	T	C	MI.11180	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	203	68	I	T	aTc/aCc	0.22	0	0	benign	0	neutral	0.76	neutral	2.81	neutral	0.32	neutral	0.88	neutral_impact	-0.3	0.76	neutral	0.98	neutral	-0.15	1.39	neutral	0.19	0.45	0.19	neutral	0.23	neutral	0.32	neutral	0.41	neutral	2	0.24	neutral	0.88	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.56	medium_impact	-1.45	low_impact	0.26	0.8	20.75	15.63	0.31	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	COSM6716704	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3509	3509	T	G	MI.11181	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	203	68	I	S	aTc/aGc	0.22	0	0	benign	0.01	neutral	0.98	neutral	2.82	neutral	0.79	neutral	0.64	neutral_impact	-0.12	0.8	neutral	0.88	neutral	1.10	11.21	neutral	0.1	0.4	0.19	neutral	0.5	disease	0.35	neutral	0.43	neutral	1	0	neutral	0.99	deleterious	-6	neutral	0.12	neutral	1.12	medium_impact	1.22	medium_impact	-1.29	low_impact	0.27	0.8	20.75	15.63	0.23	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3510	3510	C	G	MI.11182	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	204	68	I	M	atC/atG	-0.47	0	0	possibly_damaging	0.68	neutral	0.22	neutral	2.75	neutral	-1.1	neutral	0.71	neutral_impact	0.43	0.79	neutral	0.85	neutral	0.38	6.44	deleterious	0.37	0.5	0.22	neutral	0.25	neutral	0.3	neutral	0.44	neutral	1	0.82	neutral	0.27	neutral	-3	neutral	0.42	neutral	-1.06	low_impact	-0.03	medium_impact	-0.81	medium_impact	0.46	0.8	20.75	15.63	0.42	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3510	3510	C	A	MI.11183	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	204	68	I	M	atC/atA	-0.47	0	0	possibly_damaging	0.68	neutral	0.22	neutral	2.75	neutral	-1.1	neutral	0.71	neutral_impact	0.43	0.79	neutral	0.85	neutral	0.83	9.62	deleterious	0.37	0.5	0.22	neutral	0.25	neutral	0.3	neutral	0.44	neutral	1	0.82	neutral	0.27	neutral	-3	neutral	0.42	neutral	-1.06	low_impact	-0.03	medium_impact	-0.81	medium_impact	0.46	0.8	20.75	15.63	0.41	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3511	3511	A	T	MI.11184	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	205	69	T	S	Acc/Tcc	-7.36	0	0	benign	0.02	neutral	0.55	neutral	2.78	neutral	-0.19	neutral	-1.2	neutral_impact	0.58	0.84	neutral	0.98	neutral	-0.21	1.02	neutral	0.41	0.5	0.13	neutral	0.19	neutral	0.34	neutral	0.36	neutral	3	0.42	neutral	0.77	deleterious	-6	neutral	0.12	neutral	0.84	medium_impact	0.32	medium_impact	-0.68	medium_impact	0.66	0.8	27.67	19.61	0.33	N	0.00	polymorphism	1	0.03	rs386828909	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3511	3511	A	C	MI.11185	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	205	69	T	P	Acc/Ccc	-7.36	0	0	benign	0.02	neutral	0.31	neutral	2.74	neutral	-0.24	deleterious	-2.86	low_impact	1.3	0.86	neutral	0.64	neutral	0.46	7.09	deleterious	0.11	0.4	0.23	neutral	0.64	disease	0.64	disease	0.7	disease	4	0.68	neutral	0.65	deleterious	-6	neutral	0.19	neutral	0.84	medium_impact	0.08	medium_impact	-0.05	medium_impact	0.40	0.8	27.67	19.61	0.34	N	0.69	polymorphism	1	0.09	rs386828909	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3511	3511	A	G	MI.11186	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	205	69	T	A	Acc/Gcc	-7.36	0	0	benign	0.01	neutral	0.56	neutral	2.8	neutral	0.43	neutral	-1.3	low_impact	1.41	0.93	neutral	0.92	neutral	-0.43	0.33	neutral	0.25	0.45	0.17	neutral	0.11	neutral	0.49	neutral	0.33	neutral	3	0.42	neutral	0.78	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.33	medium_impact	0.04	medium_impact	0.40	0.8	27.67	19.61	0.34	N	0.13	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3512	3512	C	A	MI.11187	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	206	69	T	N	aCc/aAc	-9.89	0	0	benign	0.26	neutral	0.39	neutral	2.73	neutral	-1.55	neutral	-2.34	low_impact	1.57	0.74	neutral	0.59	neutral	0.71	8.87	deleterious	0.27	0.45	0.38	neutral	0.4	neutral	0.49	neutral	0.46	neutral	1	0.53	neutral	0.57	deleterious	-6	neutral	0.24	neutral	-0.32	medium_impact	0.17	medium_impact	0.18	medium_impact	0.55	0.8	27.67	19.61	0.36	N	0.36	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3512	3512	C	T	MI.11188	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	206	69	T	I	aCc/aTc	-9.89	0	0	benign	0.01	neutral	0.4	neutral	2.83	neutral	0.65	neutral	-0.43	neutral_impact	-0.5	0.86	neutral	0.92	neutral	-0.34	0.53	neutral	0.16	0.45	0.14	neutral	0.13	neutral	0.34	neutral	0.26	neutral	5	0.59	neutral	0.7	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.18	medium_impact	-1.63	low_impact	0.73	0.85	27.67	19.61	0.31	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3512	3512	C	G	MI.11189	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	206	69	T	S	aCc/aGc	-9.89	0	0	benign	0.02	neutral	0.55	neutral	2.78	neutral	-0.19	neutral	-1.2	neutral_impact	0.58	0.84	neutral	0.98	neutral	0.03	2.84	deleterious	0.41	0.5	0.13	neutral	0.19	neutral	0.34	neutral	0.36	neutral	3	0.42	neutral	0.77	deleterious	-6	neutral	0.12	neutral	0.84	medium_impact	0.32	medium_impact	-0.68	medium_impact	0.66	0.8	27.67	19.61	0.33	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9052	9052	A	C	MI.1119	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	526	176	S	R	Agc/Cgc	-3.34	0	0	possibly_damaging	0.48	neutral	0.09	neutral	4.28	neutral	-1.35	neutral	-2.4	medium_impact	3.02	0.81	neutral	0.51	neutral	1.15	11.47	neutral	0.15	0.65	0.52	disease	0.87	disease	0.64	disease	0.8	disease	6	0.9	neutral	0.31	neutral	0	NA	0.44	deleterious	-0.72	medium_impact	-0.28	medium_impact	1.49	medium_impact	0.84	0.9	33.63	26.97	0.31	N	0.61	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3514	3514	C	G	MI.11190	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	208	70	L	V	Ctc/Gtc	-5.07	0	0	probably_damaging	1	neutral	0.52	neutral	2.68	neutral	-0.93	neutral	-2.5	medium_impact	2.4	0.7	neutral	0.22	damaging	3.31	22.90	deleterious	0.3	0.45	0.18	neutral	0.32	neutral	0.42	neutral	0.44	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.68	deleterious	-3.57	low_impact	0.29	medium_impact	0.91	medium_impact	0.61	0.8	23.27	39.94	0.29	N	0.33	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3514	3514	C	T	MI.11191	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	208	70	L	F	Ctc/Ttc	-5.07	0	0	probably_damaging	1	neutral	0.72	neutral	2.54	neutral	-2.24	deleterious	-3.43	medium_impact	2.42	0.71	neutral	0.2	damaging	3.84	23.40	deleterious	0.24	0.45	0.42	neutral	0.51	disease	0.55	disease	0.56	disease	1	1	deleterious	0.36	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.51	medium_impact	0.93	medium_impact	0.62	0.8	23.27	39.94	0.24	N	0.50	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3514	3514	C	A	MI.11192	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	208	70	L	I	Ctc/Atc	-5.07	0	0	probably_damaging	1	neutral	0.44	neutral	2.65	neutral	-1.41	neutral	-1.7	medium_impact	2.1	0.78	neutral	0.28	damaging	3.97	23.60	deleterious	0.28	0.45	0.22	neutral	0.22	neutral	0.38	neutral	0.35	neutral	3	1	deleterious	0.22	neutral	1	deleterious	0.68	deleterious	-3.57	low_impact	0.22	medium_impact	0.65	medium_impact	0.56	0.8	23.27	39.94	0.32	N	0.40	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3515	3515	T	A	MI.11193	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	209	70	L	H	cTc/cAc	-0.01	0	0	probably_damaging	1	neutral	0.55	neutral	2.51	deleterious	-4.86	deleterious	-6.08	high_impact	4.4	0.75	neutral	0.18	damaging	3.98	23.60	deleterious	0.03	0.35	0.64	disease	0.64	disease	0.73	disease	0.73	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.32	medium_impact	2.65	high_impact	0.34	0.8	23.27	39.94	0.37	N	0.87	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3515	3515	T	C	MI.11194	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	209	70	L	P	cTc/cCc	-0.01	0	0	probably_damaging	1	neutral	0.26	neutral	2.51	deleterious	-4.47	deleterious	-6.08	medium_impact	2.62	0.74	neutral	0.17	damaging	3.77	23.40	deleterious	0.02	0.35	0.64	disease	0.65	disease	0.63	disease	0.51	disease	0	1	deleterious	0.13	neutral	1	deleterious	0.81	deleterious	-3.57	low_impact	0.02	medium_impact	1.1	medium_impact	0.34	0.8	23.27	39.94	0.26	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3515	3515	T	G	MI.11195	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	209	70	L	R	cTc/cGc	-0.01	0	0	probably_damaging	1	neutral	0.4	neutral	2.53	deleterious	-4.32	deleterious	-5.16	high_impact	4.4	0.74	neutral	0.16	damaging	4.09	23.70	deleterious	0.02	0.35	0.55	disease	0.78	disease	0.76	disease	0.77	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.18	medium_impact	2.65	high_impact	0.24	0.8	23.27	39.94	0.48	N	0.94	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3517	3517	T	C	MI.11196	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	211	71	Y	H	Tac/Cac	-0.93	0.02	0	probably_damaging	0.98	neutral	0.54	neutral	2.46	deleterious	-3.41	deleterious	-3.74	medium_impact	2.67	0.7	neutral	0.23	damaging	3.42	23.00	deleterious	0.17	0.45	0.64	disease	0.6	disease	0.8	disease	0.78	disease	6	0.98	deleterious	0.28	neutral	1	deleterious	0.79	deleterious	-2.34	low_impact	0.31	medium_impact	1.14	medium_impact	0.27	0.8	24.21	37.73	0.27	N	0.79	polymorphism	0.99	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3517	3517	T	A	MI.11197	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	211	71	Y	N	Tac/Aac	-0.93	0.02	0	probably_damaging	0.98	neutral	0.32	neutral	2.44	deleterious	-4.42	deleterious	-5.67	medium_impact	2.67	0.71	neutral	0.3	neutral	3.87	23.50	deleterious	0.08	0.35	0.78	disease	0.79	disease	0.74	disease	0.76	disease	5	0.99	deleterious	0.17	neutral	1	deleterious	0.83	deleterious	-2.34	low_impact	0.09	medium_impact	1.14	medium_impact	0.28	0.8	24.21	37.73	0.27	N	0.85	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3517	3517	T	G	MI.11198	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	211	71	Y	D	Tac/Gac	-0.93	0.02	0	probably_damaging	0.98	neutral	0.2	neutral	2.43	deleterious	-5.33	deleterious	-5.71	medium_impact	3.23	0.71	neutral	0.22	damaging	3.79	23.40	deleterious	0.04	0.35	0.87	disease	0.83	disease	0.82	disease	0.86	disease	7	0.99	deleterious	0.11	neutral	1	deleterious	0.86	deleterious	-2.34	low_impact	-0.06	medium_impact	1.63	medium_impact	0.23	0.8	24.21	37.73	0.34	N	0.93	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3518	3518	A	C	MI.11199	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	212	71	Y	S	tAc/tCc	7.34	1	0	probably_damaging	0.98	neutral	0.43	neutral	2.45	deleterious	-4.01	deleterious	-4.78	low_impact	1.43	0.71	neutral	0.24	damaging	3.59	23.20	deleterious	0.06	0.35	0.74	disease	0.71	disease	0.73	disease	0.76	disease	5	0.98	neutral	0.23	neutral	-2	neutral	0.80	deleterious	-2.34	low_impact	0.21	medium_impact	0.06	medium_impact	0.29	0.8	24.21	37.73	0.53	N	0.86	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8578	8578	C	G	MI.112	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	52	18	P	A	Ccc/Gcc	-12.13	0	0	probably_damaging	1	neutral	0.05	neutral	4.64	neutral	0.93	deleterious	-6.67	medium_impact	2.99	0.78	neutral	0.55	neutral	2.88	21.80	deleterious	0.26	0.65	0.49	neutral	0.63	disease	0.66	disease	0.6	disease	2	1	deleterious	0.03	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.43	medium_impact	1.47	medium_impact	0.72	0.9	21.24	15.57	0.37	N	0.53	polymorphism	0.97	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9052	9052	A	G	MI.1120	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	526	176	S	G	Agc/Ggc	-3.34	0	0	benign	0.14	neutral	0.43	neutral	4.35	neutral	-0.44	neutral	-1.07	neutral_impact	0.12	0.84	neutral	0.97	neutral	0.15	4.12	deleterious	0.4	0.65	0.4	neutral	0.46	neutral	0.43	neutral	0.47	neutral	1	0.49	neutral	0.65	deleterious	-6	neutral	0.18	neutral	-0.01	medium_impact	0.22	medium_impact	-1	medium_impact	0.76	0.9	33.63	26.97	0.34	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3518	3518	A	G	MI.11200	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	212	71	Y	C	tAc/tGc	7.34	1	0	probably_damaging	0.99	neutral	0.18	neutral	2.43	deleterious	-5.59	deleterious	-4.77	medium_impact	3.23	0.68	neutral	0.19	damaging	3.43	23.00	deleterious	0.05	0.35	0.88	disease	0.79	disease	0.77	disease	0.84	disease	7	0.99	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-2.62	low_impact	-0.09	medium_impact	1.63	medium_impact	0.19	0.8	24.21	37.73	0.64	P	0.84	polymorphism	0.95	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3518	3518	A	T	MI.11201	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	212	71	Y	F	tAc/tTc	7.34	1	0	benign	0.17	neutral	0.71	neutral	3.24	neutral	1.31	neutral	2.51	neutral_impact	-1.4	0.71	neutral	0.89	neutral	0.67	8.63	deleterious	0.31	0.45	0.15	neutral	0.08	neutral	0.43	neutral	0.22	neutral	6	0.17	neutral	0.77	deleterious	-6	neutral	0.19	neutral	-0.1	medium_impact	0.49	medium_impact	-2.41	low_impact	0.50	0.8	24.21	37.73	0.55	P	0.15	polymorphism	0.62	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3520	3520	A	T	MI.11202	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	214	72	I	F	Atc/Ttc	-1.85	0	0	benign	0.38	neutral	0.71	neutral	2.75	neutral	-1.28	neutral	-2.45	low_impact	1.62	0.71	neutral	0.41	neutral	3.51	23.10	deleterious	0.16	0.45	0.18	neutral	0.53	disease	0.33	neutral	0.43	neutral	1	0.29	neutral	0.67	deleterious	-6	neutral	0.29	neutral	-0.55	medium_impact	0.49	medium_impact	0.23	medium_impact	0.54	0.8	21.07	16.64	0.25	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3520	3520	A	G	MI.11203	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	214	72	I	V	Atc/Gtc	-1.85	0	0	benign	0.01	neutral	0.51	neutral	2.8	neutral	0.07	neutral	-0.65	low_impact	1.17	0.88	neutral	0.91	neutral	1.65	14.10	neutral	0.48	0.55	0.17	neutral	0.2	neutral	0.36	neutral	0.38	neutral	2	0.48	neutral	0.75	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.29	medium_impact	-0.17	medium_impact	0.43	0.8	21.07	16.64	0.39	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3520	3520	A	C	MI.11204	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	214	72	I	L	Atc/Ctc	-1.85	0	0	benign	0.01	neutral	0.66	neutral	2.85	neutral	0.18	neutral	-0.03	neutral_impact	0.4	0.84	neutral	0.71	neutral	1.12	11.31	neutral	0.23	0.45	0.14	neutral	0.16	neutral	0.27	neutral	0.26	neutral	5	0.32	neutral	0.83	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.44	medium_impact	-0.84	medium_impact	0.58	0.8	21.07	16.64	0.32	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3521	3521	T	A	MI.11205	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	215	72	I	N	aTc/aAc	-0.01	0	0	possibly_damaging	0.47	neutral	0.31	neutral	2.72	neutral	-0.85	deleterious	-4.63	medium_impact	2.49	0.69	neutral	0.45	neutral	4.34	24.00	deleterious	0.15	0.4	0.3	neutral	0.7	disease	0.51	disease	0.54	disease	1	0.65	neutral	0.42	neutral	0	NA	0.50	deleterious	-0.7	medium_impact	0.08	medium_impact	0.99	medium_impact	0.21	0.8	21.07	16.64	0.36	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3521	3521	T	G	MI.11206	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	215	72	I	S	aTc/aGc	-0.01	0	0	benign	0.26	neutral	0.44	neutral	2.76	neutral	-1.04	deleterious	-3.66	medium_impact	2.76	0.85	neutral	0.58	neutral	4.14	23.80	deleterious	0.05	0.35	0.21	neutral	0.66	disease	0.52	disease	0.59	disease	2	0.47	neutral	0.59	deleterious	-3	neutral	0.27	neutral	-0.32	medium_impact	0.22	medium_impact	1.22	medium_impact	0.22	0.8	21.07	16.64	0.31	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3521	3521	T	C	MI.11207	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	215	72	I	T	aTc/aCc	-0.01	0	0	benign	0.01	neutral	0.41	neutral	2.8	neutral	-0.89	deleterious	-2.63	low_impact	1.17	0.87	neutral	0.94	neutral	1.99	16.16	deleterious	0.13	0.4	0.22	neutral	0.29	neutral	0.4	neutral	0.43	neutral	1	0.58	neutral	0.7	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.19	medium_impact	-0.17	medium_impact	0.41	0.8	21.07	16.64	0.41	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3522	3522	C	G	MI.11208	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	216	72	I	M	atC/atG	0.45	0	0	benign	0.03	neutral	0.22	neutral	2.72	neutral	-1.57	neutral	-0.88	low_impact	1.42	0.87	neutral	0.93	neutral	2.05	16.55	deleterious	0.35	0.5	0.36	neutral	0.32	neutral	0.36	neutral	0.46	neutral	1	0.77	neutral	0.6	deleterious	-6	neutral	0.14	neutral	0.67	medium_impact	-0.03	medium_impact	0.05	medium_impact	0.66	0.8	21.07	16.64	0.49	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3522	3522	C	A	MI.11209	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	216	72	I	M	atC/atA	0.45	0	0	benign	0.03	neutral	0.22	neutral	2.72	neutral	-1.57	neutral	-0.88	low_impact	1.42	0.87	neutral	0.93	neutral	2.50	19.45	deleterious	0.35	0.5	0.36	neutral	0.32	neutral	0.36	neutral	0.46	neutral	1	0.77	neutral	0.6	deleterious	-6	neutral	0.14	neutral	0.67	medium_impact	-0.03	medium_impact	0.05	medium_impact	0.66	0.8	21.07	16.64	0.49	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9052	9052	A	T	MI.1121	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	526	176	S	C	Agc/Tgc	-3.34	0	0	possibly_damaging	0.8	deleterious	0.01	neutral	4.22	deleterious	-4.68	deleterious	-3.02	medium_impact	2.12	0.73	neutral	0.4	neutral	3.33	22.90	deleterious	0.3	0.65	0.84	disease	0.78	disease	0.55	disease	0.78	disease	6	0.99	deleterious	0.11	neutral	4	deleterious	0.64	deleterious	-1.33	low_impact	-0.84	medium_impact	0.72	medium_impact	0.76	0.9	33.63	26.97	0.27	N	0.56	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3523	3523	A	C	MI.11210	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	217	73	T	P	Acc/Ccc	-6.44	0	0.01	possibly_damaging	0.55	neutral	0.21	neutral	2.75	neutral	-2.13	neutral	-1.89	low_impact	1.84	0.65	neutral	0.45	neutral	1.64	14.08	neutral	0.07	0.35	0.53	disease	0.7	disease	0.66	disease	0.73	disease	5	0.78	neutral	0.33	neutral	-3	neutral	0.58	deleterious	-0.83	medium_impact	-0.05	medium_impact	0.42	medium_impact	0.47	0.8	17.92	27.9	0.31	N	0.34	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3523	3523	A	G	MI.11211	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	217	73	T	A	Acc/Gcc	-6.44	0	0.01	benign	0.01	neutral	0.5	neutral	2.83	neutral	0.45	neutral	0.18	neutral_impact	-0.54	0.8	neutral	0.84	neutral	-0.06	2.04	deleterious	0.2	0.45	0.17	neutral	0.1	neutral	0.44	neutral	0.3	neutral	4	0.49	neutral	0.75	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.28	medium_impact	-1.66	low_impact	0.32	0.8	17.92	27.9	0.32	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3523	3523	A	T	MI.11212	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	217	73	T	S	Acc/Tcc	-6.44	0	0.01	benign	0.18	neutral	0.41	neutral	2.78	neutral	-0.67	neutral	-0.73	neutral_impact	0.08	0.72	neutral	0.72	neutral	1.28	12.18	neutral	0.35	0.5	0.3	neutral	0.25	neutral	0.41	neutral	0.44	neutral	1	0.51	neutral	0.62	deleterious	-6	neutral	0.19	neutral	-0.13	medium_impact	0.19	medium_impact	-1.12	low_impact	0.57	0.8	17.92	27.9	0.36	N	0.23	polymorphism	1	0.02	rs878982767	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3524	3524	C	A	MI.11213	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	218	73	T	N	aCc/aAc	-4.61	0	0	possibly_damaging	0.62	neutral	0.31	neutral	2.76	neutral	-1.76	neutral	-1.89	low_impact	1.29	0.7	neutral	0.65	neutral	1.84	15.23	deleterious	0.21	0.45	0.36	neutral	0.47	neutral	0.53	disease	0.52	disease	0	0.72	neutral	0.35	neutral	-3	neutral	0.51	deleterious	-0.95	medium_impact	0.08	medium_impact	-0.06	medium_impact	0.56	0.8	17.92	27.9	0.38	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3524	3524	C	T	MI.11214	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	218	73	T	I	aCc/aTc	-4.61	0	0	benign	0.01	neutral	0.4	neutral	3	neutral	1.99	neutral	2.38	neutral_impact	-1.68	0.77	neutral	0.93	neutral	-0.81	0.04	neutral	0.12	0.4	0.13	neutral	0.14	neutral	0.3	neutral	0.26	neutral	5	0.59	neutral	0.7	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.18	medium_impact	-2.66	low_impact	0.64	0.8	17.92	27.9	0.31	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3524	3524	C	G	MI.11215	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	218	73	T	S	aCc/aGc	-4.61	0	0	benign	0.18	neutral	0.41	neutral	2.78	neutral	-0.67	neutral	-0.73	neutral_impact	0.08	0.72	neutral	0.72	neutral	1.49	13.26	neutral	0.35	0.5	0.3	neutral	0.25	neutral	0.41	neutral	0.44	neutral	1	0.51	neutral	0.62	deleterious	-6	neutral	0.19	neutral	-0.13	medium_impact	0.19	medium_impact	-1.12	low_impact	0.57	0.8	17.92	27.9	0.37	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3526	3526	G	A	MI.11216	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	220	74	A	T	Gcc/Acc	-11.27	0	0	possibly_damaging	0.86	neutral	0.39	neutral	2.61	deleterious	-3.17	neutral	-0.22	low_impact	1.26	0.82	neutral	0.54	neutral	0.44	6.96	deleterious	0.13	0.4	0.28	neutral	0.24	neutral	0.44	neutral	0.43	neutral	1	0.86	neutral	0.27	neutral	-3	neutral	0.58	deleterious	-1.49	low_impact	0.17	medium_impact	-0.09	medium_impact	0.77	0.85	60.06	9.98	0.4	N	0.78	polymorphism	1	0.02	.	.	.	.	.	thyroid tumor	COSM1133243	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3526	3526	G	C	MI.11217	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	220	74	A	P	Gcc/Ccc	-11.27	0	0	probably_damaging	0.96	neutral	0.21	neutral	2.52	deleterious	-4.59	deleterious	-2.85	high_impact	3.93	0.68	neutral	0.32	neutral	2.12	16.97	deleterious	0.04	0.35	0.56	disease	0.89	disease	0.75	disease	0.82	disease	6	0.98	neutral	0.13	neutral	2	deleterious	0.82	deleterious	-2.05	low_impact	-0.05	medium_impact	2.24	high_impact	0.55	0.8	60.06	9.98	0.42	N	0.95	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3526	3526	G	T	MI.11218	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	220	74	A	S	Gcc/Tcc	-11.27	0	0	benign	0.23	neutral	0.4	neutral	2.72	neutral	-2.77	neutral	-0.66	low_impact	0.9	0.82	neutral	0.56	neutral	0.52	7.55	deleterious	0.24	0.45	0.24	neutral	0.25	neutral	0.32	neutral	0.43	neutral	1	0.52	neutral	0.59	deleterious	-6	neutral	0.21	neutral	-0.26	medium_impact	0.18	medium_impact	-0.4	medium_impact	0.50	0.8	60.06	9.98	0.36	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3527	3527	C	T	MI.11219	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	221	74	A	V	gCc/gTc	0.68	0.26	0	possibly_damaging	0.9	neutral	0.5	neutral	2.61	neutral	-2.89	neutral	-2.1	medium_impact	2.89	0.72	neutral	0.51	neutral	2.61	20.30	deleterious	0.12	0.4	0.31	neutral	0.7	disease	0.63	disease	0.71	disease	4	0.89	neutral	0.3	neutral	0	NA	0.67	deleterious	-1.65	low_impact	0.28	medium_impact	1.34	medium_impact	0.61	0.8	60.06	9.98	0.4	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9053	9053	G	C	MI.1122	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	527	176	S	T	aGc/aCc	0.82	0	0.08	benign	0.01	neutral	0.91	neutral	4.36	neutral	-0.35	neutral	-0.41	neutral_impact	-0.59	0.82	neutral	0.82	neutral	-1.20	0.01	neutral	0.37	0.65	0.39	neutral	0.12	neutral	0.26	neutral	0.27	neutral	5	0.06	neutral	0.95	deleterious	-6	neutral	0.11	neutral	1.14	medium_impact	0.86	medium_impact	-1.6	low_impact	0.83	0.9	33.63	26.97	0.27	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3527	3527	C	A	MI.11220	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	221	74	A	D	gCc/gAc	0.68	0.26	0	probably_damaging	0.93	neutral	0.2	neutral	2.53	deleterious	-4.4	deleterious	-3.22	high_impact	4.28	0.76	neutral	0.39	neutral	2.62	20.30	deleterious	0.03	0.35	0.41	neutral	0.88	disease	0.77	disease	0.8	disease	6	0.96	neutral	0.14	neutral	2	deleterious	0.76	deleterious	-1.81	low_impact	-0.06	medium_impact	2.55	high_impact	0.31	0.8	60.06	9.98	0.54	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3527	3527	C	G	MI.11221	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	221	74	A	G	gCc/gGc	0.68	0.26	0	possibly_damaging	0.78	neutral	0.33	neutral	2.65	neutral	-2.19	deleterious	-2.63	medium_impact	2.27	0.78	neutral	0.55	neutral	2.09	16.76	deleterious	0.21	0.45	0.24	neutral	0.73	disease	0.61	disease	0.7	disease	4	0.81	neutral	0.28	neutral	0	NA	0.60	deleterious	-1.27	low_impact	0.1	medium_impact	0.79	medium_impact	0.69	0.85	60.06	9.98	0.32	N	0.66	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3529	3529	C	G	MI.11222	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	223	75	P	A	Ccg/Gcg	-5.52	0	0	probably_damaging	1	neutral	0.45	neutral	1.22	deleterious	-5.75	deleterious	-7.43	high_impact	4.12	0.59	damaging	0.07	damaging	2.97	22.10	deleterious	0.12	0.4	0.23	neutral	0.5	disease	0.7	disease	0.65	disease	3	1	deleterious	0.23	neutral	2	deleterious	0.69	deleterious	-3.57	low_impact	0.23	medium_impact	2.41	high_impact	0.54	0.8	60.06	10.38	0.35	N	0.78	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3529	3529	C	T	MI.11223	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	223	75	P	S	Ccg/Tcg	-5.52	0	0	probably_damaging	1	neutral	0.52	neutral	1.21	deleterious	-6.02	deleterious	-7.43	high_impact	3.77	0.53	damaging	0.06	damaging	3.79	23.40	deleterious	0.09	0.35	0.39	neutral	0.76	disease	0.69	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	0.29	medium_impact	2.1	high_impact	0.14	0.8	60.06	10.38	0.32	N	0.74	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3529	3529	C	A	MI.11224	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	223	75	P	T	Ccg/Acg	-5.52	0	0	probably_damaging	1	neutral	0.33	neutral	1.19	deleterious	-6.45	deleterious	-7.43	high_impact	4.38	0.57	damaging	0.05	damaging	3.59	23.20	deleterious	0.11	0.4	0.34	neutral	0.69	disease	0.7	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.71	deleterious	-3.57	low_impact	0.1	medium_impact	2.64	high_impact	0.40	0.8	60.06	10.38	0.35	N	0.91	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3530	3530	C	G	MI.11225	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	224	75	P	R	cCg/cGg	5.5	1	0	probably_damaging	1	neutral	0.28	neutral	1.18	deleterious	-6.98	deleterious	-8.36	high_impact	4.92	0.63	neutral	0.04	damaging	3.49	23.10	deleterious	0.04	0.35	0.52	disease	0.86	disease	0.82	disease	0.79	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.05	medium_impact	3.11	high_impact	0.42	0.8	60.06	10.38	0.71	P	0.71	polymorphism	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3530	3530	C	A	MI.11226	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	224	75	P	Q	cCg/cAg	5.5	1	0	probably_damaging	1	neutral	0.24	neutral	1.18	deleterious	-7.25	deleterious	-7.43	high_impact	4.92	0.59	damaging	0.04	damaging	3.96	23.60	deleterious	0.09	0.4	0.54	disease	0.82	disease	0.74	disease	0.75	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	-0.01	medium_impact	3.11	high_impact	0.37	0.8	60.06	10.38	0.68	P	0.84	polymorphism	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3530	3530	C	T	MI.11227	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	224	75	P	L	cCg/cTg	5.5	1	0	probably_damaging	1	neutral	0.9	neutral	1.19	deleterious	-6.82	deleterious	-9.29	high_impact	3.95	0.62	neutral	0.04	damaging	4.31	24.00	deleterious	0.08	0.35	0.18	neutral	0.86	disease	0.68	disease	0.72	disease	4	1	deleterious	0.45	neutral	2	deleterious	0.71	deleterious	-3.57	low_impact	0.81	medium_impact	2.26	high_impact	0.70	0.85	60.06	10.38	0.49	N	1.00	polymorphism	0.99	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3532	3532	A	G	MI.11228	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	226	76	T	A	Acc/Gcc	-20	0	0	benign	0.01	neutral	0.37	neutral	2.82	neutral	0.7	neutral	-2.19	neutral_impact	0.76	0.9	neutral	0.86	neutral	0.66	8.56	deleterious	0.26	0.45	0.12	neutral	0.29	neutral	0.33	neutral	0.42	neutral	2	0.62	neutral	0.68	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.15	medium_impact	-0.53	medium_impact	0.27	0.8	25.79	45.19	0.39	N	0.01	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3532	3532	A	T	MI.11229	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	226	76	T	S	Acc/Tcc	-20	0	0	benign	0.25	neutral	0.34	neutral	2.78	neutral	-0.12	neutral	-2.13	medium_impact	1.97	0.83	neutral	0.73	neutral	0.73	9.05	deleterious	0.39	0.5	0.24	neutral	0.49	neutral	0.54	disease	0.65	disease	3	0.59	neutral	0.55	deleterious	-3	neutral	0.21	neutral	-0.3	medium_impact	0.11	medium_impact	0.53	medium_impact	0.50	0.8	25.79	45.19	0.36	N	0.28	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9053	9053	G	T	MI.1123	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	527	176	S	I	aGc/aTc	0.82	0	0.08	benign	0.32	neutral	0.13	neutral	4.25	neutral	-2.16	deleterious	-3.37	low_impact	1.43	0.8	neutral	0.66	neutral	2.32	18.30	deleterious	0.29	0.65	0.47	neutral	0.85	disease	0.57	disease	0.76	disease	5	0.85	neutral	0.41	neutral	-6	neutral	0.33	neutral	-0.45	medium_impact	-0.18	medium_impact	0.13	medium_impact	0.84	0.9	33.63	26.97	0.31	N	0.66	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3532	3532	A	C	MI.11230	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	226	76	T	P	Acc/Ccc	-20	0	0	possibly_damaging	0.65	neutral	0.42	neutral	2.72	neutral	-2.12	deleterious	-3.48	medium_impact	2.94	0.64	neutral	0.36	neutral	2.08	16.70	deleterious	0.07	0.35	0.5	neutral	0.86	disease	0.66	disease	0.77	disease	5	0.66	neutral	0.39	neutral	0	NA	0.61	deleterious	-1	low_impact	0.2	medium_impact	1.38	medium_impact	0.32	0.8	25.79	45.19	0.31	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3533	3533	C	G	MI.11231	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	227	76	T	S	aCc/aGc	1.14	0	0	benign	0.25	neutral	0.34	neutral	2.78	neutral	-0.12	neutral	-2.13	medium_impact	1.97	0.83	neutral	0.73	neutral	0.34	6.12	deleterious	0.39	0.5	0.24	neutral	0.49	neutral	0.54	disease	0.65	disease	3	0.59	neutral	0.55	deleterious	-3	neutral	0.21	neutral	-0.3	medium_impact	0.11	medium_impact	0.53	medium_impact	0.50	0.8	25.79	45.19	0.35	N	0.28	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3533	3533	C	T	MI.11232	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	227	76	T	I	aCc/aTc	1.14	0	0	benign	0.02	neutral	0.56	neutral	2.85	neutral	1.54	neutral	-1.1	neutral_impact	0.12	0.83	neutral	0.93	neutral	0.12	3.86	deleterious	0.12	0.4	0.12	neutral	0.2	neutral	0.27	neutral	0.35	neutral	3	0.42	neutral	0.77	deleterious	-6	neutral	0.11	neutral	0.84	medium_impact	0.33	medium_impact	-1.08	low_impact	0.55	0.8	25.79	45.19	0.39	N	0.03	polymorphism	1	0.02	rs377091327	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3533	3533	C	A	MI.11233	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	227	76	T	N	aCc/aAc	1.14	0	0	possibly_damaging	0.65	neutral	0.23	neutral	2.73	neutral	-2.08	deleterious	-3.1	medium_impact	3.48	0.67	neutral	0.52	neutral	1.74	14.64	neutral	0.25	0.45	0.3	neutral	0.71	disease	0.56	disease	0.7	disease	4	0.79	neutral	0.29	neutral	0	NA	0.52	deleterious	-1	low_impact	-0.02	medium_impact	1.85	medium_impact	0.56	0.8	25.79	45.19	0.43	N	0.55	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3535	3535	T	A	MI.11234	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	229	77	L	M	Tta/Ata	-8.97	0	0.01	probably_damaging	1	neutral	0.29	neutral	2.37	neutral	-2.86	neutral	-0.72	neutral_impact	0.72	0.85	neutral	0.85	neutral	2.18	17.38	deleterious	0.24	0.45	0.39	neutral	0.12	neutral	0.28	neutral	0.29	neutral	4	1	deleterious	0.15	neutral	-2	neutral	0.67	deleterious	-3.57	low_impact	0.06	medium_impact	-0.56	medium_impact	0.43	0.8	59.43	10.49	0.44	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3535	3535	T	G	MI.11235	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	229	77	L	V	Tta/Gta	-8.97	0	0.01	probably_damaging	1	neutral	0.38	neutral	2.45	neutral	-1.82	neutral	-2.15	medium_impact	2.1	0.7	neutral	0.52	neutral	3.28	22.80	deleterious	0.22	0.45	0.25	neutral	0.36	neutral	0.33	neutral	0.45	neutral	1	1	deleterious	0.19	neutral	1	deleterious	0.69	deleterious	-3.57	low_impact	0.16	medium_impact	0.65	medium_impact	0.42	0.8	59.43	10.49	0.38	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3536	3536	T	G	MI.11236	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	230	77	L	W	tTa/tGa	-1.39	0	0	probably_damaging	1	neutral	0.15	neutral	2.29	deleterious	-6.16	deleterious	-4.78	high_impact	3.71	0.68	neutral	0.37	neutral	3.64	23.20	deleterious	0.06	0.35	0.85	disease	0.7	disease	0.58	disease	0.74	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	-0.15	medium_impact	2.05	high_impact	0.19	0.8	59.43	10.49	0.38	N	0.92	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3536	3536	T	C	MI.11237	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	230	77	L	S	tTa/tCa	-1.39	0	0	probably_damaging	1	neutral	0.52	neutral	2.32	deleterious	-4.13	deleterious	-4.67	medium_impact	3.37	0.73	neutral	0.5	neutral	3.63	23.20	deleterious	0.06	0.35	0.63	disease	0.57	disease	0.55	disease	0.62	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.29	medium_impact	1.76	medium_impact	0.27	0.8	59.43	10.49	0.31	N	0.91	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3537	3537	A	C	MI.11238	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	231	77	L	F	ttA/ttC	5.5	1	0.03	probably_damaging	1	neutral	0.84	neutral	2.39	neutral	-2.56	deleterious	-3.15	medium_impact	2.12	0.7	neutral	0.43	neutral	3.38	22.90	deleterious	0.2	0.45	0.33	neutral	0.31	neutral	0.31	neutral	0.46	neutral	1	1	deleterious	0.42	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.68	medium_impact	0.66	medium_impact	0.45	0.8	59.43	10.49	0.55	P	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3537	3537	A	T	MI.11239	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	231	77	L	F	ttA/ttT	5.5	1	0.03	probably_damaging	1	neutral	0.84	neutral	2.39	neutral	-2.56	deleterious	-3.15	medium_impact	2.12	0.7	neutral	0.43	neutral	3.48	23.10	deleterious	0.2	0.45	0.33	neutral	0.31	neutral	0.31	neutral	0.46	neutral	1	1	deleterious	0.42	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.68	medium_impact	0.66	medium_impact	0.45	0.8	59.43	10.49	0.55	P	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9053	9053	G	A	MI.1124	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	527	176	S	N	aGc/aAc	0.82	0	0.08	benign	0.22	neutral	0.8	neutral	4.33	neutral	-0.67	neutral	-0.69	low_impact	0.82	0.87	neutral	0.83	neutral	0.59	8.11	deleterious	0.63	0.7	0.44	neutral	0.48	neutral	0.36	neutral	0.48	neutral	0	0.12	neutral	0.79	deleterious	-6	neutral	0.31	neutral	-0.23	medium_impact	0.63	medium_impact	-0.4	medium_impact	0.72	0.9	33.63	26.97	0.22	N	0.03	polymorphism	1	0.01	rs199646902	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3538	3538	G	A	MI.11240	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	232	78	A	T	Gct/Act	0.45	0.99	0	probably_damaging	1	neutral	0.37	neutral	2.71	neutral	-1.29	deleterious	-3.5	medium_impact	2.08	0.67	neutral	0.1	damaging	4.10	23.70	deleterious	0.15	0.45	0.29	neutral	0.57	disease	0.35	neutral	0.45	neutral	1	1	deleterious	0.19	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.15	medium_impact	0.63	medium_impact	0.57	0.8	14.78	29.75	0.43	N	0.55	polymorphism	1	0.10	.	.	.	.	.	.	COSM1155617	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3538	3538	G	T	MI.11241	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	232	78	A	S	Gct/Tct	0.45	0.99	0	probably_damaging	1	neutral	0.49	neutral	2.78	neutral	-1.33	deleterious	-2.53	low_impact	1.66	0.81	neutral	0.67	neutral	2.51	19.50	deleterious	0.27	0.45	0.15	neutral	0.38	neutral	0.29	neutral	0.42	neutral	2	1	deleterious	0.25	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.27	medium_impact	0.26	medium_impact	0.39	0.8	14.78	29.75	0.43	N	0.15	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3538	3538	G	C	MI.11242	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	232	78	A	P	Gct/Cct	0.45	0.99	0	probably_damaging	1	neutral	0.32	neutral	2.63	deleterious	-3.94	deleterious	-4.5	high_impact	3.88	0.71	neutral	0.06	damaging	3.69	23.30	deleterious	0.06	0.35	0.56	disease	0.88	disease	0.68	disease	0.74	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.09	medium_impact	2.2	high_impact	0.54	0.8	14.78	29.75	0.49	N	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3539	3539	C	G	MI.11243	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	233	78	A	G	gCt/gGt	7.11	1	0	probably_damaging	1	neutral	0.38	neutral	2.65	neutral	-2.14	deleterious	-3.58	low_impact	1.81	0.74	neutral	0.17	damaging	3.81	23.40	deleterious	0.21	0.45	0.27	neutral	0.69	disease	0.35	neutral	0.5	neutral	0	1	deleterious	0.19	neutral	-2	neutral	0.69	deleterious	-3.57	low_impact	0.16	medium_impact	0.39	medium_impact	0.58	0.8	14.78	29.75	0.54	N	0.36	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3539	3539	C	A	MI.11244	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	233	78	A	D	gCt/gAt	7.11	1	0	probably_damaging	1	neutral	0.18	neutral	2.65	deleterious	-4.38	deleterious	-5.35	high_impact	3.68	0.77	neutral	0.06	damaging	4.42	24.20	deleterious	0.05	0.35	0.51	disease	0.88	disease	0.66	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.09	medium_impact	2.03	high_impact	0.28	0.8	14.78	29.75	0.57	N	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3539	3539	C	T	MI.11245	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	233	78	A	V	gCt/gTt	7.11	1	0	probably_damaging	1	neutral	0.48	neutral	2.75	neutral	-0.68	deleterious	-3.65	medium_impact	2.68	0.67	neutral	0.07	damaging	4.24	23.90	deleterious	0.17	0.45	0.22	neutral	0.72	disease	0.55	disease	0.64	disease	3	1	deleterious	0.24	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.26	medium_impact	1.15	medium_impact	0.58	0.8	14.78	29.75	0.55	P	0.75	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3541	3541	C	G	MI.11246	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	235	79	L	V	Ctc/Gtc	-6.67	0	0	possibly_damaging	0.74	neutral	0.54	neutral	2.48	neutral	-1.53	deleterious	-2.6	medium_impact	2.88	0.78	neutral	0.5	neutral	3.32	22.90	deleterious	0.24	0.45	0.21	neutral	0.38	neutral	0.56	disease	0.44	neutral	1	0.71	neutral	0.4	neutral	0	NA	0.52	deleterious	-1.18	low_impact	0.31	medium_impact	1.33	medium_impact	0.43	0.8	22.33	29.28	0.28	N	0.57	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3541	3541	C	T	MI.11247	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	235	79	L	F	Ctc/Ttc	-6.67	0	0	benign	0.08	neutral	0.99	neutral	2.49	neutral	-1.45	deleterious	-2.94	low_impact	1.03	0.79	neutral	0.75	neutral	2.73	21.00	deleterious	0.19	0.45	0.24	neutral	0.22	neutral	0.35	neutral	0.38	neutral	2	0.05	neutral	0.96	deleterious	-6	neutral	0.18	neutral	0.25	medium_impact	1.39	medium_impact	-0.29	medium_impact	0.32	0.8	22.33	29.28	0.25	N	0.26	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3541	3541	C	A	MI.11248	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	235	79	L	I	Ctc/Atc	-6.67	0	0	possibly_damaging	0.74	neutral	0.53	neutral	2.42	neutral	-2	neutral	-1.68	medium_impact	2.29	0.79	neutral	0.52	neutral	3.96	23.60	deleterious	0.24	0.45	0.27	neutral	0.4	neutral	0.46	neutral	0.42	neutral	2	0.71	neutral	0.4	neutral	0	NA	0.56	deleterious	-1.18	low_impact	0.3	medium_impact	0.81	medium_impact	0.33	0.8	22.33	29.28	0.3	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3542	3542	T	G	MI.11249	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	236	79	L	R	cTc/cGc	-0.47	0	0	probably_damaging	0.97	neutral	0.28	neutral	2.29	deleterious	-4.99	deleterious	-5.33	high_impact	4.49	0.67	neutral	0.3	neutral	4.06	23.70	deleterious	0.03	0.35	0.49	neutral	0.79	disease	0.7	disease	0.7	disease	4	0.97	neutral	0.16	neutral	2	deleterious	0.79	deleterious	-2.17	low_impact	0.05	medium_impact	2.73	high_impact	0.14	0.8	22.33	29.28	0.45	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9055	9055	G	C	MI.1125	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	529	177	A	P	Gcc/Ccc	-7.28	0	0.06	possibly_damaging	0.85	neutral	0.1	neutral	4.24	deleterious	-4.5	deleterious	-4.07	medium_impact	3.02	0.71	neutral	0.52	neutral	3.93	23.50	deleterious	0.1	0.65	0.84	disease	0.91	disease	0.76	disease	0.82	disease	6	0.95	neutral	0.13	neutral	0	NA	0.82	deleterious	-1.47	low_impact	-0.25	medium_impact	1.49	medium_impact	0.78	0.9	17.26	13.64	0.32	N	0.91	polymorphism	1	0.09	rs193303045	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3542	3542	T	A	MI.11250	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	236	79	L	H	cTc/cAc	-0.47	0	0	probably_damaging	0.98	neutral	0.44	neutral	2.28	deleterious	-5.63	deleterious	-6.02	high_impact	4.49	0.7	neutral	0.33	neutral	3.94	23.50	deleterious	0.06	0.35	0.59	disease	0.66	disease	0.65	disease	0.66	disease	3	0.98	deleterious	0.23	neutral	2	deleterious	0.76	deleterious	-2.34	low_impact	0.22	medium_impact	2.73	high_impact	0.25	0.8	22.33	29.28	0.42	N	0.88	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3542	3542	T	C	MI.11251	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	236	79	L	P	cTc/cCc	-0.47	0	0	probably_damaging	0.98	neutral	0.45	neutral	2.28	deleterious	-5.57	deleterious	-6.25	high_impact	4.14	0.68	neutral	0.34	neutral	3.78	23.40	deleterious	0.03	0.35	0.3	neutral	0.72	disease	0.68	disease	0.67	disease	3	0.98	deleterious	0.24	neutral	2	deleterious	0.75	deleterious	-2.34	low_impact	0.23	medium_impact	2.43	high_impact	0.28	0.8	22.33	29.28	0.34	N	0.93	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3544	3544	A	T	MI.11252	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	238	80	T	S	Acc/Tcc	-5.75	0	0	benign	0.01	neutral	0.62	neutral	2.73	neutral	-0.48	neutral	-1.97	low_impact	1.02	0.81	neutral	0.97	neutral	0.06	3.14	deleterious	0.42	0.55	0.15	neutral	0.36	neutral	0.27	neutral	0.44	neutral	1	0.36	neutral	0.81	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	0.39	medium_impact	-0.3	medium_impact	0.47	0.8	47.17	8.89	0.36	N	0.16	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3544	3544	A	G	MI.11253	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	238	80	T	A	Acc/Gcc	-5.75	0	0	benign	0.01	neutral	0.66	neutral	2.8	neutral	0.74	neutral	-2.41	low_impact	1.73	0.9	neutral	0.96	neutral	0.31	5.84	deleterious	0.27	0.45	0.16	neutral	0.32	neutral	0.26	neutral	0.44	neutral	1	0.32	neutral	0.83	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	0.44	medium_impact	0.32	medium_impact	0.33	0.8	47.17	8.89	0.37	N	0.24	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3544	3544	A	C	MI.11254	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	238	80	T	P	Acc/Ccc	-5.75	0	0	possibly_damaging	0.55	neutral	0.4	neutral	2.69	neutral	-2.69	deleterious	-3.83	high_impact	3.58	0.62	neutral	0.34	neutral	2.97	22.10	deleterious	0.06	0.35	0.52	disease	0.84	disease	0.53	disease	0.71	disease	4	0.6	neutral	0.43	neutral	1	deleterious	0.60	deleterious	-0.83	medium_impact	0.18	medium_impact	1.94	medium_impact	0.31	0.8	47.17	8.89	0.36	N	0.93	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3545	3545	C	G	MI.11255	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	239	80	T	S	aCc/aGc	-0.47	0	0	benign	0.01	neutral	0.62	neutral	2.73	neutral	-0.48	neutral	-1.97	low_impact	1.02	0.81	neutral	0.97	neutral	0.26	5.25	deleterious	0.42	0.55	0.15	neutral	0.36	neutral	0.27	neutral	0.44	neutral	1	0.36	neutral	0.81	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	0.39	medium_impact	-0.3	medium_impact	0.47	0.8	47.17	8.89	0.37	N	0.16	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3545	3545	C	T	MI.11256	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	239	80	T	I	aCc/aTc	-0.47	0	0	benign	0.02	neutral	0.58	neutral	2.89	neutral	0.5	deleterious	-2.67	neutral_impact	0.56	0.84	neutral	0.68	neutral	1.00	10.64	neutral	0.14	0.4	0.17	neutral	0.52	disease	0.29	neutral	0.42	neutral	2	0.39	neutral	0.78	deleterious	-6	neutral	0.15	neutral	0.84	medium_impact	0.35	medium_impact	-0.7	medium_impact	0.50	0.8	47.17	8.89	0.25	N	0.77	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3545	3545	C	A	MI.11257	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	239	80	T	N	aCc/aAc	-0.47	0	0	benign	0.26	neutral	0.3	neutral	2.7	neutral	-2.88	deleterious	-3.14	high_impact	3.58	0.67	neutral	0.48	neutral	1.92	15.71	deleterious	0.29	0.45	0.45	neutral	0.72	disease	0.39	neutral	0.52	disease	0	0.64	neutral	0.52	deleterious	-2	neutral	0.31	neutral	-0.32	medium_impact	0.07	medium_impact	1.94	medium_impact	0.59	0.8	47.17	8.89	0.46	N	0.51	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3547	3547	A	G	MI.11258	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	241	81	I	V	Atc/Gtc	-5.52	0	0	benign	0.04	neutral	0.54	neutral	2.86	neutral	-0.07	neutral	-0.92	low_impact	1.33	0.73	neutral	0.69	neutral	2.89	21.80	deleterious	0.4	0.5	0.14	neutral	0.2	neutral	0.45	neutral	0.34	neutral	3	0.42	neutral	0.75	deleterious	-6	neutral	0.11	neutral	0.55	medium_impact	0.31	medium_impact	-0.03	medium_impact	0.28	0.8	24.21	38.08	0.33	N	0.59	polymorphism	1	0.03	rs28358586	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3547	3547	A	C	MI.11259	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	241	81	I	L	Atc/Ctc	-5.52	0	0	benign	0.04	neutral	0.94	neutral	3.01	neutral	0.2	neutral	1.35	neutral_impact	-1.31	0.67	neutral	0.89	neutral	0.92	10.17	neutral	0.24	0.45	0.18	neutral	0.09	neutral	0.21	neutral	0.27	neutral	5	0.01	neutral	0.95	deleterious	-6	neutral	0.10	neutral	0.55	medium_impact	0.94	medium_impact	-2.33	low_impact	0.39	0.8	24.21	38.08	0.34	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9055	9055	G	T	MI.1126	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	529	177	A	S	Gcc/Tcc	-7.28	0	0.06	benign	0.05	neutral	0.32	neutral	4.28	neutral	-2.59	neutral	-2.16	medium_impact	2	0.72	neutral	0.61	neutral	3.79	23.40	deleterious	0.35	0.65	0.64	disease	0.74	disease	0.42	neutral	0.54	disease	1	0.65	neutral	0.64	deleterious	-3	neutral	0.28	neutral	0.46	medium_impact	0.11	medium_impact	0.62	medium_impact	0.88	0.9	17.26	13.64	0.3	N	0.19	polymorphism	1	0.02	rs193303045	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3547	3547	A	T	MI.11260	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	241	81	I	F	Atc/Ttc	-5.52	0	0	possibly_damaging	0.78	neutral	0.83	neutral	2.74	neutral	-1.4	neutral	-2.09	low_impact	1.69	0.7	neutral	0.51	neutral	3.76	23.30	deleterious	0.16	0.45	0.19	neutral	0.56	disease	0.48	neutral	0.5	disease	0	0.74	neutral	0.53	deleterious	-3	neutral	0.56	deleterious	-1.27	low_impact	0.66	medium_impact	0.29	medium_impact	0.37	0.8	24.21	38.08	0.31	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3548	3548	T	A	MI.11261	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	242	81	I	N	aTc/aAc	-1.16	0	0	possibly_damaging	0.87	neutral	0.29	neutral	2.73	deleterious	-3.14	deleterious	-4.87	medium_impact	2.38	0.68	neutral	0.51	neutral	4.35	24.10	deleterious	0.12	0.4	0.5	neutral	0.73	disease	0.54	disease	0.69	disease	4	0.9	neutral	0.21	neutral	0	NA	0.67	deleterious	-1.53	low_impact	0.06	medium_impact	0.89	medium_impact	0.19	0.8	24.21	38.08	0.35	N	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3548	3548	T	G	MI.11262	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	242	81	I	S	aTc/aGc	-1.16	0	0	possibly_damaging	0.69	neutral	0.55	neutral	2.8	neutral	-0.89	deleterious	-3.94	low_impact	1.52	0.69	neutral	0.53	neutral	4.18	23.80	deleterious	0.08	0.35	0.23	neutral	0.58	disease	0.53	disease	0.6	disease	2	0.65	neutral	0.43	neutral	-3	neutral	0.41	neutral	-1.08	low_impact	0.32	medium_impact	0.14	medium_impact	0.21	0.8	24.21	38.08	0.26	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3548	3548	T	C	MI.11263	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	242	81	I	T	aTc/aCc	-1.16	0	0	benign	0.06	neutral	0.52	neutral	2.77	neutral	-0.5	deleterious	-3	low_impact	1.64	0.64	neutral	0.69	neutral	3.31	22.90	deleterious	0.22	0.45	0.27	neutral	0.31	neutral	0.46	neutral	0.41	neutral	2	0.42	neutral	0.73	deleterious	-6	neutral	0.14	neutral	0.37	medium_impact	0.29	medium_impact	0.24	medium_impact	0.29	0.8	24.21	38.08	0.4	N	0.86	polymorphism	1	0.11	rs876661353	Uncertain_significance	not_specified	236826	MedGen:CN169374	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3549	3549	C	G	MI.11264	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	243	81	I	M	atC/atG	7.34	0.95	0.03	possibly_damaging	0.83	neutral	0.3	neutral	2.74	neutral	-1.74	neutral	-0.36	low_impact	1.4	0.71	neutral	0.61	neutral	3.25	22.80	deleterious	0.32	0.5	0.28	neutral	0.37	neutral	0.44	neutral	0.41	neutral	2	0.86	neutral	0.24	neutral	-3	neutral	0.57	deleterious	-1.4	low_impact	0.07	medium_impact	0.03	medium_impact	0.41	0.8	24.21	38.08	0.6	P	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3549	3549	C	A	MI.11265	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	243	81	I	M	atC/atA	7.34	0.95	0.03	possibly_damaging	0.83	neutral	0.3	neutral	2.74	neutral	-1.74	neutral	-0.36	low_impact	1.4	0.71	neutral	0.61	neutral	3.74	23.30	deleterious	0.32	0.5	0.28	neutral	0.37	neutral	0.44	neutral	0.41	neutral	2	0.86	neutral	0.24	neutral	-3	neutral	0.57	deleterious	-1.4	low_impact	0.07	medium_impact	0.03	medium_impact	0.41	0.8	24.21	38.08	0.6	P	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3550	3550	G	T	MI.11266	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	244	82	A	S	Gct/Tct	-4.61	0	0	benign	0.2	neutral	0.45	neutral	2.75	neutral	-1.91	neutral	-2.48	low_impact	1.64	0.82	neutral	0.2	damaging	2.46	19.21	deleterious	0.28	0.45	0.22	neutral	0.19	neutral	0.31	neutral	0.31	neutral	4	0.46	neutral	0.63	deleterious	-6	neutral	0.21	neutral	-0.19	medium_impact	0.23	medium_impact	0.24	medium_impact	0.33	0.8	54.72	9.4	0.33	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3550	3550	G	A	MI.11267	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	244	82	A	T	Gct/Act	-4.61	0	0	benign	0.12	neutral	0.31	neutral	2.68	neutral	-2.22	deleterious	-3.5	medium_impact	3.16	0.72	neutral	0.12	damaging	4.08	23.70	deleterious	0.19	0.45	0.24	neutral	0.52	disease	0.57	disease	0.55	disease	1	0.64	neutral	0.6	deleterious	-3	neutral	0.19	neutral	0.06	medium_impact	0.08	medium_impact	1.57	medium_impact	0.65	0.8	54.72	9.4	0.39	N	0.70	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3550	3550	G	C	MI.11268	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	244	82	A	P	Gct/Cct	-4.61	0	0	probably_damaging	0.96	neutral	0.4	neutral	2.62	deleterious	-3.42	deleterious	-4.49	medium_impact	2.98	0.71	neutral	0.07	damaging	3.67	23.30	deleterious	0.09	0.35	0.57	disease	0.78	disease	0.71	disease	0.73	disease	5	0.96	neutral	0.22	neutral	1	deleterious	0.77	deleterious	-2.05	low_impact	0.18	medium_impact	1.41	medium_impact	0.46	0.8	54.72	9.4	0.25	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3551	3551	C	T	MI.11269	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	245	82	A	V	gCt/gTt	5.04	1	0	possibly_damaging	0.83	neutral	0.45	neutral	2.78	neutral	-1.24	deleterious	-3.65	medium_impact	2.54	0.71	neutral	0.07	damaging	4.32	24.00	deleterious	0.18	0.45	0.16	neutral	0.57	disease	0.52	disease	0.49	neutral	0	0.83	neutral	0.31	neutral	0	NA	0.56	deleterious	-1.4	low_impact	0.23	medium_impact	1.03	medium_impact	0.51	0.8	54.72	9.4	0.58	P	0.72	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	C3551T	LHON	+	-	Reported	1	.	P	P	damaging
chrM	9055	9055	G	A	MI.1127	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	529	177	A	T	Gcc/Acc	-7.28	0	0.06	possibly_damaging	0.51	neutral	0.55	neutral	4.34	neutral	-2.28	deleterious	-2.61	low_impact	1.31	0.93	neutral	0.68	neutral	3.12	22.60	deleterious	0.39	0.65	0.5	disease	0.61	disease	0.41	neutral	0.45	neutral	1	0.47	neutral	0.52	deleterious	-3	neutral	0.53	deleterious	-0.77	medium_impact	0.34	medium_impact	0.03	medium_impact	0.70	0.9	17.26	13.64	0.2	N	0.34	polymorphism	1	0.06	rs193303045	.	.	.	.	.	.	.	1.93	G9055A	PD protective factor	+	-	Reported	2	N	P	N,P	damaging
chrM	3551	3551	C	G	MI.11270	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	245	82	A	G	gCt/gGt	5.04	1	0	possibly_damaging	0.74	neutral	0.18	neutral	2.64	deleterious	-3.47	deleterious	-3.56	medium_impact	3.16	0.77	neutral	0.11	damaging	3.88	23.50	deleterious	0.26	0.45	0.33	neutral	0.55	disease	0.57	disease	0.62	disease	2	0.87	neutral	0.22	neutral	0	NA	0.55	deleterious	-1.18	low_impact	-0.09	medium_impact	1.57	medium_impact	0.53	0.8	54.72	9.4	0.61	P	0.79	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3551	3551	C	A	MI.11271	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	245	82	A	D	gCt/gAt	5.04	1	0	possibly_damaging	0.89	neutral	0.11	neutral	2.64	deleterious	-4.87	deleterious	-5.31	high_impact	4.41	0.79	neutral	0.07	damaging	4.32	24.00	deleterious	0.06	0.35	0.6	disease	0.8	disease	0.69	disease	0.69	disease	4	0.96	neutral	0.11	neutral	1	deleterious	0.72	deleterious	-1.6	low_impact	-0.23	medium_impact	2.66	high_impact	0.28	0.8	54.72	9.4	0.6	P	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3553	3553	C	A	MI.11272	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	247	83	L	I	Ctt/Att	-6.9	0	0	probably_damaging	1	neutral	0.2	neutral	2.54	neutral	-1.88	neutral	-1.6	low_impact	1.9	0.89	neutral	0.6	neutral	3.99	23.60	deleterious	0.28	0.45	0.19	neutral	0.28	neutral	0.46	neutral	0.42	neutral	2	1	deleterious	0.1	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	-0.06	medium_impact	0.47	medium_impact	0.30	0.8	56.92	9.14	0.48	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3553	3553	C	T	MI.11273	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	247	83	L	F	Ctt/Ttt	-6.9	0	0	probably_damaging	1	neutral	0.23	neutral	2.53	neutral	-1.36	deleterious	-3.27	medium_impact	2.31	0.88	neutral	0.32	neutral	3.80	23.40	deleterious	0.3	0.45	0.29	neutral	0.29	neutral	0.38	neutral	0.42	neutral	2	1	deleterious	0.12	neutral	1	deleterious	0.69	deleterious	-3.57	low_impact	-0.02	medium_impact	0.83	medium_impact	0.36	0.8	56.92	9.14	0.41	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3553	3553	C	G	MI.11274	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	247	83	L	V	Ctt/Gtt	-6.9	0	0	probably_damaging	1	neutral	0.23	neutral	2.53	neutral	-1.54	neutral	-2.36	medium_impact	2.92	0.85	neutral	0.18	damaging	3.34	22.90	deleterious	0.29	0.45	0.2	neutral	0.3	neutral	0.56	disease	0.45	neutral	1	1	deleterious	0.12	neutral	1	deleterious	0.67	deleterious	-3.57	low_impact	-0.02	medium_impact	1.36	medium_impact	0.36	0.8	56.92	9.14	0.37	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3554	3554	T	C	MI.11275	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	248	83	L	P	cTt/cCt	-1.85	0	0	probably_damaging	1	neutral	0.11	neutral	2.42	deleterious	-5.01	deleterious	-5.9	high_impact	4.47	0.61	neutral	0.08	damaging	3.66	23.20	deleterious	0.05	0.35	0.62	disease	0.64	disease	0.7	disease	0.71	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.23	medium_impact	2.72	high_impact	0.24	0.8	56.92	9.14	0.39	N	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3554	3554	T	G	MI.11276	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	248	83	L	R	cTt/cGt	-1.85	0	0	probably_damaging	1	deleterious	0.03	neutral	2.43	deleterious	-4.52	deleterious	-5.03	high_impact	4.47	0.66	neutral	0.1	damaging	3.99	23.60	deleterious	0.04	0.35	0.52	disease	0.72	disease	0.7	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-3.57	low_impact	-0.57	medium_impact	2.72	high_impact	0.15	0.8	56.92	9.14	0.41	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3554	3554	T	A	MI.11277	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	248	83	L	H	cTt/cAt	-1.85	0	0	probably_damaging	1	neutral	0.09	neutral	2.42	deleterious	-5.05	deleterious	-5.91	high_impact	4.47	0.7	neutral	0.08	damaging	3.95	23.60	deleterious	0.07	0.35	0.61	disease	0.59	disease	0.66	disease	0.66	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	-0.29	medium_impact	2.72	high_impact	0.21	0.8	56.92	9.14	0.41	N	0.97	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3556	3556	C	G	MI.11278	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	250	84	L	V	Cta/Gta	-4.38	0	0	benign	0.04	neutral	0.17	neutral	2.63	neutral	-1.26	neutral	-0.05	low_impact	1.56	0.83	neutral	0.45	neutral	2.12	16.97	deleterious	0.35	0.5	0.19	neutral	0.16	neutral	0.25	neutral	0.28	neutral	4	0.82	neutral	0.57	deleterious	-6	neutral	0.13	neutral	0.55	medium_impact	-0.11	medium_impact	0.17	medium_impact	0.38	0.8	30.19	51.37	0.51	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3556	3556	C	A	MI.11279	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	250	84	L	M	Cta/Ata	-4.38	0	0	probably_damaging	0.9	neutral	0.34	neutral	2.49	neutral	-2.39	neutral	0.4	neutral_impact	0.26	0.86	neutral	0.9	neutral	1.97	16.00	deleterious	0.22	0.45	0.31	neutral	0.08	neutral	0.24	neutral	0.27	neutral	5	0.91	neutral	0.22	neutral	-2	neutral	0.60	deleterious	-1.65	low_impact	0.11	medium_impact	-0.96	medium_impact	0.33	0.8	30.19	51.37	0.5	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9056	9056	C	G	MI.1128	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	530	177	A	G	gCc/gGc	2.67	0.99	0	benign	0.39	neutral	0.2	neutral	4.27	neutral	-2.48	deleterious	-3.33	low_impact	1.29	0.74	neutral	0.63	neutral	2.94	22.00	deleterious	0.22	0.65	0.79	disease	0.72	disease	0.41	neutral	0.62	disease	2	0.76	neutral	0.41	neutral	-6	neutral	0.53	deleterious	-0.57	medium_impact	-0.05	medium_impact	0.01	medium_impact	0.73	0.9	17.26	13.64	0.41	N	0.54	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3557	3557	T	A	MI.11280	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	251	84	L	Q	cTa/cAa	-0.01	0	0	probably_damaging	0.93	neutral	0.06	neutral	2.47	deleterious	-4.51	neutral	-1.28	high_impact	3.54	0.76	neutral	0.24	damaging	3.80	23.40	deleterious	0.06	0.35	0.52	disease	0.47	neutral	0.5	neutral	0.45	neutral	1	0.98	deleterious	0.07	neutral	2	deleterious	0.68	deleterious	-1.81	low_impact	-0.4	medium_impact	1.9	medium_impact	0.20	0.8	30.19	51.37	0.44	N	0.42	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3557	3557	T	G	MI.11281	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	251	84	L	R	cTa/cGa	-0.01	0	0	probably_damaging	0.9	neutral	0.07	neutral	2.47	deleterious	-4.34	neutral	-1.62	high_impact	3.54	0.73	neutral	0.2	damaging	2.88	21.80	deleterious	0.04	0.35	0.5	disease	0.69	disease	0.63	disease	0.7	disease	4	0.98	neutral	0.09	neutral	2	deleterious	0.73	deleterious	-1.65	low_impact	-0.35	medium_impact	1.9	medium_impact	0.16	0.8	30.19	51.37	0.39	N	0.51	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3557	3557	T	C	MI.11282	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	251	84	L	P	cTa/cCa	-0.01	0	0	probably_damaging	0.93	neutral	0.12	neutral	2.45	deleterious	-4.49	neutral	-1.92	high_impact	3.54	0.76	neutral	0.22	damaging	3.67	23.30	deleterious	0.04	0.35	0.6	disease	0.71	disease	0.63	disease	0.7	disease	4	0.97	neutral	0.1	neutral	2	deleterious	0.75	deleterious	-1.81	low_impact	-0.21	medium_impact	1.9	medium_impact	0.26	0.8	30.19	51.37	0.39	N	0.67	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3559	3559	C	A	MI.11283	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	253	85	L	M	Cta/Ata	-9.43	0	0	benign	0.15	neutral	0.29	neutral	2.71	neutral	-1.57	neutral	-0.16	neutral_impact	0.16	0.8	neutral	0.92	neutral	1.64	14.06	neutral	0.23	0.45	0.22	neutral	0.07	neutral	0.21	neutral	0.26	neutral	5	0.66	neutral	0.57	deleterious	-6	neutral	0.15	neutral	-0.04	medium_impact	0.06	medium_impact	-1.05	low_impact	0.54	0.8	30.82	39.41	0.51	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3559	3559	C	G	MI.11284	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	253	85	L	V	Cta/Gta	-9.43	0	0	possibly_damaging	0.53	neutral	0.18	neutral	2.78	neutral	-0.28	neutral	-1.05	low_impact	1.5	0.86	neutral	0.77	neutral	3.25	22.80	deleterious	0.28	0.45	0.16	neutral	0.18	neutral	0.28	neutral	0.33	neutral	3	0.81	neutral	0.33	neutral	-3	neutral	0.35	neutral	-0.8	medium_impact	-0.09	medium_impact	0.12	medium_impact	0.42	0.8	30.82	39.41	0.46	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3560	3560	T	G	MI.11285	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	254	85	L	R	cTa/cGa	-0.24	0	0	probably_damaging	0.93	deleterious	0.04	neutral	2.72	deleterious	-3.09	deleterious	-4.4	medium_impact	3.25	0.68	neutral	0.5	neutral	4.04	23.70	deleterious	0.06	0.35	0.49	neutral	0.73	disease	0.64	disease	0.71	disease	4	0.99	deleterious	0.06	neutral	5	deleterious	0.73	deleterious	-1.81	low_impact	-0.5	medium_impact	1.65	medium_impact	0.24	0.8	30.82	39.41	0.4	N	0.91	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3560	3560	T	A	MI.11286	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	254	85	L	Q	cTa/cAa	-0.24	0	0	probably_damaging	0.93	deleterious	0.04	neutral	2.72	deleterious	-3.2	deleterious	-4.12	medium_impact	3.25	0.71	neutral	0.56	neutral	4.14	23.80	deleterious	0.09	0.35	0.51	disease	0.54	disease	0.51	disease	0.54	disease	1	0.99	deleterious	0.06	neutral	5	deleterious	0.68	deleterious	-1.81	low_impact	-0.5	medium_impact	1.65	medium_impact	0.24	0.8	30.82	39.41	0.46	N	0.78	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3560	3560	T	C	MI.11287	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	254	85	L	P	cTa/cCa	-0.24	0	0	probably_damaging	0.95	deleterious	0.03	neutral	2.69	neutral	-2.14	deleterious	-5.03	medium_impact	3.25	0.6	damaging	0.43	neutral	3.88	23.50	deleterious	0.05	0.35	0.6	disease	0.73	disease	0.66	disease	0.72	disease	4	0.99	deleterious	0.04	neutral	5	deleterious	0.76	deleterious	-1.95	low_impact	-0.57	medium_impact	1.65	medium_impact	0.26	0.8	30.82	39.41	0.33	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3562	3562	T	G	MI.11288	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	256	86	W	G	Tga/Gga	-3.46	0	0	probably_damaging	1	neutral	0.08	neutral	2.45	deleterious	-4.45	deleterious	-12.07	high_impact	4.24	0.75	neutral	0.14	damaging	3.78	23.40	deleterious	0.08	0.35	0.45	neutral	0.67	disease	0.77	disease	0.73	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	-0.32	medium_impact	2.51	high_impact	0.10	0.8	60.38	10.52	0.48	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3562	3562	T	C	MI.11289	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	256	86	W	R	Tga/Cga	-3.46	0	0	probably_damaging	1	neutral	0.06	neutral	2.47	deleterious	-3.16	deleterious	-12.99	high_impact	4.09	0.7	neutral	0.08	damaging	3.47	23.00	deleterious	0.06	0.35	0.51	disease	0.83	disease	0.82	disease	0.77	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	-0.4	medium_impact	2.38	high_impact	0.08	0.8	60.38	10.52	0.47	N	0.98	polymorphism	1	0.27	.	.	.	.	.	.	COSM6716700	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9056	9056	C	T	MI.1129	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	530	177	A	V	gCc/gTc	2.67	0.99	0	possibly_damaging	0.59	neutral	0.25	neutral	4.33	neutral	-1.51	deleterious	-3.19	medium_impact	2.29	0.59	damaging	0.48	neutral	4.59	24.40	deleterious	0.32	0.65	0.48	neutral	0.83	disease	0.6	disease	0.7	disease	4	0.76	neutral	0.33	neutral	0	NA	0.63	deleterious	-0.91	medium_impact	0.02	medium_impact	0.87	medium_impact	0.78	0.9	17.26	13.64	0.48	N	0.63	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3563	3563	G	C	MI.11290	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	257	86	W	S	tGa/tCa	5.73	1	0	probably_damaging	1	neutral	0.25	neutral	2.46	deleterious	-3.46	deleterious	-12.99	high_impact	3.55	0.69	neutral	0.14	damaging	3.92	23.50	deleterious	0.08	0.35	0.37	neutral	0.78	disease	0.75	disease	0.74	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	0.01	medium_impact	1.91	medium_impact	0.11	0.8	60.38	10.52	0.53	P	0.99	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3563	3563	G	T	MI.11291	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	257	86	W	L	tGa/tTa	5.73	1	0	probably_damaging	1	neutral	1	neutral	2.52	neutral	-2.15	deleterious	-12.06	medium_impact	2.96	0.68	neutral	0.09	damaging	4.12	23.80	deleterious	0.1	0.4	0.19	neutral	0.74	disease	0.73	disease	0.7	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.70	deleterious	-3.57	low_impact	1.96	high_impact	1.4	medium_impact	0.07	0.8	60.38	10.52	0.42	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3564	3564	A	C	MI.11292	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	258	86	W	C	tgA/tgC	8.95	1	0	probably_damaging	1	deleterious	0.04	neutral	2.44	deleterious	-5.1	deleterious	-12.06	high_impact	3.69	0.73	neutral	0.1	damaging	3.88	23.50	deleterious	0.08	0.35	0.47	neutral	0.75	disease	0.78	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-3.57	low_impact	-0.5	medium_impact	2.03	high_impact	0.10	0.8	60.38	10.52	0.56	P	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3564	3564	A	T	MI.11293	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	258	86	W	C	tgA/tgT	8.95	1	0	probably_damaging	1	deleterious	0.04	neutral	2.44	deleterious	-5.1	deleterious	-12.06	high_impact	3.69	0.73	neutral	0.1	damaging	3.97	23.60	deleterious	0.08	0.35	0.47	neutral	0.75	disease	0.78	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-3.57	low_impact	-0.5	medium_impact	2.03	high_impact	0.10	0.8	60.38	10.52	0.56	P	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3565	3565	A	G	MI.11294	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	259	87	T	A	Acc/Gcc	2.06	0.94	0	benign	0.01	neutral	0.26	neutral	2.87	neutral	1.46	neutral	-0.44	neutral_impact	-0.55	0.94	neutral	0.96	neutral	0.99	10.60	neutral	0.38	0.5	0.16	neutral	0.07	neutral	0.21	neutral	0.21	neutral	6	0.73	neutral	0.63	deleterious	-6	neutral	0.08	neutral	1.12	medium_impact	0.02	medium_impact	-1.67	low_impact	0.37	0.8	24.84	25.63	0.45	N	0.30	polymorphism	1	0.01	rs2854133	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3565	3565	A	C	MI.11295	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	259	87	T	P	Acc/Ccc	2.06	0.94	0	possibly_damaging	0.66	deleterious	0.03	neutral	2.73	neutral	-2.49	deleterious	-2.67	low_impact	1.38	0.64	neutral	0.39	neutral	3.44	23.00	deleterious	0.1	0.4	0.48	neutral	0.71	disease	0.52	disease	0.6	disease	2	0.97	neutral	0.19	neutral	1	deleterious	0.51	deleterious	-1.02	low_impact	-0.57	medium_impact	0.02	medium_impact	0.49	0.8	24.84	25.63	0.41	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3565	3565	A	T	MI.11296	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	259	87	T	S	Acc/Tcc	2.06	0.94	0	benign	0.03	neutral	0.3	neutral	2.8	neutral	-0.29	neutral	-1.17	neutral_impact	0.58	0.88	neutral	0.93	neutral	1.99	16.13	deleterious	0.43	0.55	0.27	neutral	0.21	neutral	0.22	neutral	0.37	neutral	3	0.68	neutral	0.64	deleterious	-6	neutral	0.13	neutral	0.67	medium_impact	0.07	medium_impact	-0.68	medium_impact	0.63	0.8	24.84	25.63	0.5	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3566	3566	C	A	MI.11297	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	260	87	T	N	aCc/aAc	-1.85	0	0	possibly_damaging	0.51	neutral	0.06	neutral	2.75	neutral	-2.59	deleterious	-2.63	medium_impact	2.11	0.67	neutral	0.55	neutral	3.65	23.20	deleterious	0.31	0.45	0.44	neutral	0.47	neutral	0.36	neutral	0.5	neutral	0	0.93	neutral	0.28	neutral	0	NA	0.33	neutral	-0.77	medium_impact	-0.4	medium_impact	0.65	medium_impact	0.57	0.8	24.84	25.63	0.44	N	0.76	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3566	3566	C	T	MI.11298	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	260	87	T	I	aCc/aTc	-1.85	0	0	benign	0.02	neutral	0.21	neutral	2.82	neutral	0.19	neutral	-0.59	neutral_impact	0.23	0.82	neutral	0.94	neutral	1.09	11.17	neutral	0.18	0.45	0.21	neutral	0.26	neutral	0.25	neutral	0.43	neutral	1	0.78	neutral	0.6	deleterious	-6	neutral	0.12	neutral	0.84	medium_impact	-0.05	medium_impact	-0.99	medium_impact	0.58	0.8	24.84	25.63	0.42	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3566	3566	C	G	MI.11299	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	260	87	T	S	aCc/aGc	-1.85	0	0	benign	0.03	neutral	0.3	neutral	2.8	neutral	-0.29	neutral	-1.17	neutral_impact	0.58	0.88	neutral	0.93	neutral	2.11	16.91	deleterious	0.43	0.55	0.27	neutral	0.21	neutral	0.22	neutral	0.37	neutral	3	0.68	neutral	0.64	deleterious	-6	neutral	0.13	neutral	0.67	medium_impact	0.07	medium_impact	-0.68	medium_impact	0.63	0.8	24.84	25.63	0.49	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8578	8578	C	T	MI.113	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	52	18	P	S	Ccc/Tcc	-12.13	0	0	probably_damaging	1	neutral	0.84	neutral	4.67	neutral	0.93	deleterious	-6.59	low_impact	1.46	0.83	neutral	0.65	neutral	3.60	23.20	deleterious	0.47	0.65	0.46	neutral	0.66	disease	0.42	neutral	0.46	neutral	1	1	deleterious	0.42	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.7	medium_impact	0.15	medium_impact	0.41	0.9	21.24	15.57	0.24	N	0.49	polymorphism	0.95	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9056	9056	C	A	MI.1130	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	530	177	A	D	gCc/gAc	2.67	0.99	0	possibly_damaging	0.64	neutral	0.1	neutral	4.24	deleterious	-3.98	deleterious	-4.76	high_impact	3.58	0.71	neutral	0.46	neutral	4.61	24.40	deleterious	0.09	0.65	0.88	disease	0.93	disease	0.75	disease	0.85	disease	7	0.91	neutral	0.23	neutral	1	deleterious	0.73	deleterious	-0.99	medium_impact	-0.25	medium_impact	1.97	medium_impact	0.66	0.9	17.26	13.64	0.48	N	0.95	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3568	3568	C	T	MI.11300	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	262	88	P	S	Ccc/Tcc	-7.36	0	0	probably_damaging	1	neutral	0.39	neutral	2.8	neutral	-1.68	deleterious	-7.39	medium_impact	2.38	0.8	neutral	0.13	damaging	3.83	23.40	deleterious	0.3	0.45	0.39	neutral	0.57	disease	0.33	neutral	0.47	neutral	1	1	deleterious	0.2	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.17	medium_impact	0.89	medium_impact	0.21	0.8	59.43	10.54	0.26	N	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3568	3568	C	A	MI.11301	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	262	88	P	T	Ccc/Acc	-7.36	0	0	probably_damaging	1	neutral	0.3	neutral	2.83	neutral	-1.3	deleterious	-7.4	medium_impact	2.37	0.67	neutral	0.1	damaging	3.62	23.20	deleterious	0.22	0.45	0.35	neutral	0.59	disease	0.41	neutral	0.48	neutral	0	1	deleterious	0.15	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.07	medium_impact	0.88	medium_impact	0.51	0.8	59.43	10.54	0.29	N	0.91	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3568	3568	C	G	MI.11302	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	262	88	P	A	Ccc/Gcc	-7.36	0	0	probably_damaging	1	neutral	0.66	neutral	2.83	neutral	-0.44	deleterious	-7.4	medium_impact	2.38	0.72	neutral	0.13	damaging	3.01	22.30	deleterious	0.24	0.45	0.32	neutral	0.45	neutral	0.44	neutral	0.46	neutral	1	1	deleterious	0.33	neutral	1	deleterious	0.69	deleterious	-3.57	low_impact	0.44	medium_impact	0.89	medium_impact	0.58	0.8	59.43	10.54	0.24	N	0.78	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3569	3569	C	G	MI.11303	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	263	88	P	R	cCc/cGc	5.5	1	0	probably_damaging	1	neutral	0.23	neutral	2.77	neutral	-2.89	deleterious	-8.33	high_impact	3.91	0.77	neutral	0.1	damaging	3.56	23.10	deleterious	0.13	0.4	0.49	neutral	0.79	disease	0.7	disease	0.7	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.02	medium_impact	2.23	high_impact	0.39	0.8	59.43	10.54	0.59	P	0.71	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3569	3569	C	A	MI.11304	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	263	88	P	H	cCc/cAc	5.5	1	0	probably_damaging	1	neutral	0.36	neutral	2.75	deleterious	-3.48	deleterious	-8.33	high_impact	3.91	0.7	neutral	0.1	damaging	3.93	23.50	deleterious	0.13	0.4	0.63	disease	0.74	disease	0.66	disease	0.67	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.14	medium_impact	2.23	high_impact	0.34	0.8	59.43	10.54	0.63	P	0.69	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3569	3569	C	T	MI.11305	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	263	88	P	L	cCc/cTc	5.5	1	0	probably_damaging	1	neutral	1	neutral	2.89	neutral	-0.14	deleterious	-9.25	low_impact	1.44	0.7	neutral	0.08	damaging	4.32	24.00	deleterious	0.22	0.45	0.33	neutral	0.62	disease	0.31	neutral	0.44	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.70	deleterious	-3.57	low_impact	1.96	high_impact	0.07	medium_impact	0.63	0.8	59.43	10.54	0.4	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3571	3571	C	A	MI.11306	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	265	89	L	I	Ctc/Atc	-9.43	0	0.01	benign	0.17	neutral	0.44	neutral	2.67	neutral	-0.6	neutral	-1.23	neutral_impact	0.7	0.88	neutral	0.83	neutral	2.71	20.90	deleterious	0.33	0.5	0.29	neutral	0.11	neutral	0.13	neutral	0.29	neutral	4	0.47	neutral	0.64	deleterious	-6	neutral	0.20	neutral	-0.1	medium_impact	0.22	medium_impact	-0.58	medium_impact	0.40	0.8	33.02	10.16	0.5	N	0.07	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3571	3571	C	G	MI.11307	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	265	89	L	V	Ctc/Gtc	-9.43	0	0.01	benign	0.17	neutral	0.33	neutral	2.64	neutral	-0.74	neutral	-1.85	low_impact	1.86	0.88	neutral	0.59	neutral	3.26	22.80	deleterious	0.32	0.5	0.19	neutral	0.28	neutral	0.21	neutral	0.44	neutral	1	0.61	neutral	0.58	deleterious	-6	neutral	0.18	neutral	-0.1	medium_impact	0.1	medium_impact	0.44	medium_impact	0.52	0.8	33.02	10.16	0.47	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3571	3571	C	T	MI.11308	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	265	89	L	F	Ctc/Ttc	-9.43	0	0.01	probably_damaging	0.96	neutral	0.54	neutral	2.43	neutral	-2.83	deleterious	-2.87	low_impact	1.14	0.82	neutral	0.52	neutral	3.83	23.40	deleterious	0.3	0.45	0.2	neutral	0.33	neutral	0.21	neutral	0.45	neutral	1	0.95	neutral	0.29	neutral	-2	neutral	0.67	deleterious	-2.05	low_impact	0.31	medium_impact	-0.19	medium_impact	0.48	0.8	33.02	10.16	0.23	N	0.86	polymorphism	1	0.09	rs200453691	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3572	3572	T	A	MI.11309	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	266	89	L	H	cTc/cAc	-2.54	0	0	probably_damaging	0.99	neutral	0.28	neutral	2.36	deleterious	-5.54	deleterious	-5.4	high_impact	3.87	0.71	neutral	0.32	neutral	4.01	23.60	deleterious	0.06	0.35	0.67	disease	0.66	disease	0.62	disease	0.7	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.77	deleterious	-2.62	low_impact	0.05	medium_impact	2.19	high_impact	0.14	0.8	33.02	10.16	0.35	N	0.86	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9058	9058	A	G	MI.1131	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	532	178	T	A	Acc/Gcc	-10.75	0	0	benign	0.02	neutral	0.73	neutral	4.44	neutral	-0.96	neutral	-1.97	neutral_impact	-0.14	0.97	neutral	0.87	neutral	1.97	15.99	deleterious	0.49	0.65	0.28	neutral	0.17	neutral	0.35	neutral	0.27	neutral	5	0.23	neutral	0.86	deleterious	-6	neutral	0.08	neutral	0.85	medium_impact	0.54	medium_impact	-1.22	low_impact	0.54	0.9	22.57	14.83	0.35	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	2.07	A9058G	Possibly LVNC cardiomyopathy-associated	+	-	Reported	1	.	P	P	neutral
chrM	3572	3572	T	C	MI.11310	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	266	89	L	P	cTc/cCc	-2.54	0	0	probably_damaging	0.98	neutral	0.27	neutral	2.37	deleterious	-5.36	deleterious	-5.43	high_impact	3.87	0.75	neutral	0.35	neutral	3.79	23.40	deleterious	0.05	0.35	0.68	disease	0.79	disease	0.52	disease	0.68	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-2.34	low_impact	0.03	medium_impact	2.19	high_impact	0.15	0.8	33.02	10.16	0.36	N	0.92	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3572	3572	T	G	MI.11311	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	266	89	L	R	cTc/cGc	-2.54	0	0	probably_damaging	0.97	neutral	0.15	neutral	2.37	deleterious	-4.83	deleterious	-4.59	high_impact	3.87	0.67	neutral	0.3	neutral	4.10	23.70	deleterious	0.04	0.35	0.59	disease	0.79	disease	0.66	disease	0.73	disease	5	0.98	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-2.17	low_impact	-0.15	medium_impact	2.19	high_impact	0.10	0.8	33.02	10.16	0.37	N	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3574	3574	C	T	MI.11312	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	268	90	P	S	Ccc/Tcc	-6.21	0	0	probably_damaging	1	neutral	0.36	neutral	1.3	deleterious	-5.81	deleterious	-7.27	medium_impact	3.28	0.79	neutral	0.13	damaging	3.75	23.30	deleterious	0.13	0.4	0.22	neutral	0.72	disease	0.63	disease	0.61	disease	2	1	deleterious	0.18	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.14	medium_impact	1.68	medium_impact	0.16	0.8	60.38	10.17	0.27	N	0.74	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3574	3574	C	G	MI.11313	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	268	90	P	A	Ccc/Gcc	-6.21	0	0	probably_damaging	1	neutral	0.38	neutral	1.31	deleterious	-5.54	deleterious	-7.29	high_impact	4.17	0.75	neutral	0.14	damaging	2.99	22.20	deleterious	0.13	0.4	0.21	neutral	0.59	disease	0.72	disease	0.69	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.69	deleterious	-3.57	low_impact	0.16	medium_impact	2.45	high_impact	0.47	0.8	60.38	10.17	0.36	N	0.78	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3574	3574	C	A	MI.11314	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	268	90	P	T	Ccc/Acc	-6.21	0	0	probably_damaging	1	neutral	0.43	neutral	1.28	deleterious	-6.24	deleterious	-7.26	medium_impact	3.42	0.7	neutral	0.12	damaging	3.58	23.20	deleterious	0.13	0.4	0.23	neutral	0.74	disease	0.6	disease	0.61	disease	2	1	deleterious	0.22	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.21	medium_impact	1.8	medium_impact	0.44	0.8	60.38	10.17	0.26	N	0.91	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3575	3575	C	T	MI.11315	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	269	90	P	L	cCc/cTc	5.27	1	0	probably_damaging	1	neutral	1	neutral	1.28	deleterious	-6.59	deleterious	-9.14	high_impact	3.52	0.74	neutral	0.08	damaging	4.31	24.00	deleterious	0.1	0.4	0.25	neutral	0.81	disease	0.7	disease	0.71	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.72	deleterious	-3.57	low_impact	1.96	high_impact	1.89	medium_impact	0.46	0.8	60.38	10.17	0.41	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3575	3575	C	A	MI.11316	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	269	90	P	H	cCc/cAc	5.27	1	0	probably_damaging	1	neutral	0.29	neutral	1.26	deleterious	-7.86	deleterious	-8.24	high_impact	4.53	0.74	neutral	0.1	damaging	3.94	23.50	deleterious	0.09	0.35	0.42	neutral	0.82	disease	0.79	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.06	medium_impact	2.77	high_impact	0.25	0.8	60.38	10.17	0.6	P	0.69	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3575	3575	C	G	MI.11317	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	269	90	P	R	cCc/cGc	5.27	1	0	probably_damaging	1	neutral	0.19	neutral	1.27	deleterious	-6.76	deleterious	-8.23	high_impact	4.87	0.78	neutral	0.1	damaging	3.49	23.10	deleterious	0.06	0.35	0.28	neutral	0.84	disease	0.81	disease	0.76	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	-0.08	medium_impact	3.06	high_impact	0.36	0.8	60.38	10.17	0.64	P	0.71	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3577	3577	A	C	MI.11318	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	271	91	M	L	Ata/Cta	-8.97	0	0	benign	0.01	neutral	1	neutral	2.94	neutral	1.34	neutral	-1.25	neutral_impact	0.42	0.9	neutral	0.82	neutral	1.43	12.94	neutral	0.28	0.45	0.13	neutral	0.34	neutral	0.31	neutral	0.44	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	1.96	high_impact	-0.82	medium_impact	0.27	0.8	52.52	9.42	0.34	N	0.95	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3577	3577	A	T	MI.11319	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	271	91	M	L	Ata/Tta	-8.97	0	0	benign	0.01	neutral	1	neutral	2.94	neutral	1.34	neutral	-1.25	neutral_impact	0.42	0.9	neutral	0.82	neutral	1.57	13.67	neutral	0.28	0.45	0.13	neutral	0.34	neutral	0.31	neutral	0.44	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	1.96	high_impact	-0.82	medium_impact	0.27	0.8	52.52	9.42	0.34	N	0.95	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9058	9058	A	T	MI.1132	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	532	178	T	S	Acc/Tcc	-10.75	0	0	benign	0.28	neutral	0.66	neutral	4.33	neutral	-1.8	neutral	-2.23	low_impact	0.9	0.81	neutral	0.59	neutral	3.85	23.40	deleterious	0.42	0.65	0.48	neutral	0.39	neutral	0.36	neutral	0.42	neutral	2	0.25	neutral	0.69	deleterious	-6	neutral	0.38	neutral	-0.37	medium_impact	0.45	medium_impact	-0.33	medium_impact	0.74	0.9	22.57	14.83	0.25	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3577	3577	A	G	MI.11320	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	271	91	M	V	Ata/Gta	-8.97	0	0	benign	0.08	neutral	0.45	neutral	2.88	neutral	1.03	neutral	-2.38	low_impact	1.7	0.8	neutral	0.12	damaging	2.61	20.20	deleterious	0.23	0.45	0.15	neutral	0.52	disease	0.38	neutral	0.46	neutral	1	0.49	neutral	0.69	deleterious	-6	neutral	0.15	neutral	0.25	medium_impact	0.23	medium_impact	0.3	medium_impact	0.26	0.8	52.52	9.42	0.25	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3578	3578	T	A	MI.11321	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	272	91	M	K	aTa/aAa	1.37	0.77	0	possibly_damaging	0.61	neutral	0.16	neutral	2.72	neutral	-1.85	deleterious	-4.71	medium_impact	3.06	0.62	neutral	0.08	damaging	3.88	23.50	deleterious	0.05	0.35	0.22	neutral	0.81	disease	0.75	disease	0.76	disease	5	0.85	neutral	0.28	neutral	0	NA	0.57	deleterious	-0.93	medium_impact	-0.13	medium_impact	1.48	medium_impact	0.11	0.8	52.52	9.42	0.38	N	1.00	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3578	3578	T	C	MI.11322	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	272	91	M	T	aTa/aCa	1.37	0.77	0	benign	0.41	neutral	0.4	neutral	2.76	neutral	-0.25	deleterious	-4.1	medium_impact	2.51	0.82	neutral	0.14	damaging	2.84	21.60	deleterious	0.17	0.45	0.17	neutral	0.65	disease	0.58	disease	0.49	neutral	0	0.54	neutral	0.5	deleterious	-3	neutral	0.46	deleterious	-0.6	medium_impact	0.18	medium_impact	1	medium_impact	0.09	0.8	52.52	9.42	0.25	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3579	3579	A	C	MI.11323	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	273	91	M	I	atA/atC	5.73	0.97	0	benign	0.02	neutral	0.43	neutral	2.82	neutral	0.82	neutral	-2.12	medium_impact	2.11	0.85	neutral	0.29	neutral	2.17	17.32	deleterious	0.24	0.45	0.13	neutral	0.53	disease	0.31	neutral	0.45	neutral	1	0.55	neutral	0.71	deleterious	-3	neutral	0.14	neutral	0.84	medium_impact	0.21	medium_impact	0.65	medium_impact	0.31	0.8	52.52	9.42	0.52	N	0.95	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3579	3579	A	T	MI.11324	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	273	91	M	I	atA/atT	5.73	0.97	0	benign	0.02	neutral	0.43	neutral	2.82	neutral	0.82	neutral	-2.12	medium_impact	2.11	0.85	neutral	0.29	neutral	2.26	17.90	deleterious	0.24	0.45	0.13	neutral	0.53	disease	0.31	neutral	0.45	neutral	1	0.55	neutral	0.71	deleterious	-3	neutral	0.14	neutral	0.84	medium_impact	0.21	medium_impact	0.65	medium_impact	0.31	0.8	52.52	9.42	0.52	P	0.95	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3580	3580	C	A	MI.11325	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	274	92	P	T	Ccc/Acc	-3.23	0	0	probably_damaging	1	neutral	0.39	neutral	2.82	neutral	-1.16	deleterious	-7.4	medium_impact	2.29	0.65	neutral	0.13	damaging	3.62	23.20	deleterious	0.22	0.45	0.17	neutral	0.62	disease	0.4	neutral	0.47	neutral	1	1	deleterious	0.2	neutral	1	deleterious	0.67	deleterious	-3.57	low_impact	0.17	medium_impact	0.81	medium_impact	0.40	0.8	58.81	10.66	0.27	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3580	3580	C	G	MI.11326	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	274	92	P	A	Ccc/Gcc	-3.23	0	0	probably_damaging	1	neutral	0.51	neutral	2.85	neutral	-0.64	deleterious	-7.41	medium_impact	2.31	0.69	neutral	0.17	damaging	3.04	22.30	deleterious	0.22	0.45	0.15	neutral	0.51	disease	0.4	neutral	0.48	neutral	0	1	deleterious	0.26	neutral	1	deleterious	0.67	deleterious	-3.57	low_impact	0.29	medium_impact	0.83	medium_impact	0.47	0.8	58.81	10.66	0.26	N	0.78	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3580	3580	C	T	MI.11327	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	274	92	P	S	Ccc/Tcc	-3.23	0	0	probably_damaging	1	neutral	0.4	neutral	2.86	neutral	-0.88	deleterious	-7.4	medium_impact	1.99	0.71	neutral	0.17	damaging	3.83	23.40	deleterious	0.24	0.45	0.14	neutral	0.57	disease	0.24	neutral	0.42	neutral	2	1	deleterious	0.2	neutral	1	deleterious	0.67	deleterious	-3.57	low_impact	0.18	medium_impact	0.55	medium_impact	0.12	0.8	58.81	10.66	0.29	N	0.74	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3581	3581	C	A	MI.11328	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	275	92	P	H	cCc/cAc	5.5	1	0	probably_damaging	1	neutral	0.54	neutral	2.78	neutral	-2.87	deleterious	-8.34	medium_impact	2.88	0.68	neutral	0.13	damaging	4.05	23.70	deleterious	0.13	0.4	0.29	neutral	0.76	disease	0.4	neutral	0.56	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.31	medium_impact	1.33	medium_impact	0.25	0.8	58.81	10.66	0.42	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3581	3581	C	G	MI.11329	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	275	92	P	R	cCc/cGc	5.5	1	0	probably_damaging	1	neutral	0.35	neutral	2.82	neutral	-1.68	deleterious	-8.34	high_impact	3.92	0.73	neutral	0.14	damaging	3.52	23.10	deleterious	0.13	0.4	0.17	neutral	0.79	disease	0.61	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.70	deleterious	-3.57	low_impact	0.12	medium_impact	2.24	high_impact	0.30	0.8	58.81	10.66	0.56	P	0.71	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9058	9058	A	C	MI.1133	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	532	178	T	P	Acc/Ccc	-10.75	0	0	possibly_damaging	0.68	neutral	0.16	neutral	4.29	deleterious	-3.29	deleterious	-3.85	medium_impact	2.56	0.86	neutral	0.44	neutral	3.99	23.60	deleterious	0.13	0.65	0.79	disease	0.84	disease	0.73	disease	0.81	disease	6	0.86	neutral	0.24	neutral	0	NA	0.75	deleterious	-1.07	low_impact	-0.12	medium_impact	1.1	medium_impact	0.61	0.9	22.57	14.83	0.31	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3581	3581	C	T	MI.11330	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	275	92	P	L	cCc/cTc	5.5	1	0	probably_damaging	1	neutral	0.65	neutral	2.82	neutral	-1.85	deleterious	-9.26	medium_impact	2.12	0.77	neutral	0.13	damaging	4.26	23.90	deleterious	0.16	0.45	0.27	neutral	0.69	disease	0.41	neutral	0.49	neutral	0	1	deleterious	0.33	neutral	1	deleterious	0.69	deleterious	-3.57	low_impact	0.43	medium_impact	0.66	medium_impact	0.56	0.8	58.81	10.66	0.42	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3583	3583	A	T	MI.11331	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	277	93	N	Y	Aac/Tac	-9.89	0	0	benign	0	neutral	1	neutral	2.81	neutral	-1.7	neutral	2.49	neutral_impact	-0.36	0.81	neutral	0.97	neutral	0.67	8.66	deleterious	0.18	0.45	0.13	neutral	0.15	neutral	0.16	neutral	0.24	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	1.96	high_impact	-1.5	low_impact	0.17	0.8	24.53	32.23	0.36	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3583	3583	A	G	MI.11332	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	277	93	N	D	Aac/Gac	-9.89	0	0	benign	0.01	neutral	0.2	neutral	2.78	neutral	0.01	neutral	-1.15	low_impact	1.34	0.8	neutral	0.65	neutral	1.87	15.41	deleterious	0.32	0.5	0.31	neutral	0.22	neutral	0.33	neutral	0.4	neutral	2	0.8	neutral	0.6	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	-0.06	medium_impact	-0.02	medium_impact	0.23	0.8	24.53	32.23	0.46	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3583	3583	A	C	MI.11333	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	277	93	N	H	Aac/Cac	-9.89	0	0	benign	0.01	neutral	0.54	neutral	2.76	neutral	-1.35	neutral	2.16	neutral_impact	0.14	0.71	neutral	0.97	neutral	-0.17	1.29	neutral	0.25	0.45	0.25	neutral	0.15	neutral	0.18	neutral	0.28	neutral	4	0.45	neutral	0.77	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.31	medium_impact	-1.07	low_impact	0.27	0.8	24.53	32.23	0.47	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3584	3584	A	T	MI.11334	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	278	93	N	I	aAc/aTc	-2.08	0	0	benign	0.01	neutral	0.4	neutral	2.78	neutral	-1.75	neutral	-0.71	neutral_impact	0.41	0.83	neutral	0.81	neutral	1.32	12.36	neutral	0.19	0.45	0.11	neutral	0.3	neutral	0.17	neutral	0.43	neutral	1	0.59	neutral	0.7	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.18	medium_impact	-0.83	medium_impact	0.11	0.8	24.53	32.23	0.44	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3584	3584	A	C	MI.11335	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	278	93	N	T	aAc/aCc	-2.08	0	0	benign	0.11	neutral	0.39	neutral	2.82	neutral	-0.24	neutral	-0.68	neutral_impact	0.12	0.84	neutral	0.8	neutral	0.77	9.27	deleterious	0.23	0.45	0.15	neutral	0.16	neutral	0.15	neutral	0.29	neutral	4	0.55	neutral	0.64	deleterious	-6	neutral	0.12	neutral	0.1	medium_impact	0.17	medium_impact	-1.08	low_impact	0.30	0.8	24.53	32.23	0.47	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3584	3584	A	G	MI.11336	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	278	93	N	S	aAc/aGc	-2.08	0	0	benign	0.01	neutral	0.4	neutral	2.81	neutral	0.56	neutral	-0.28	low_impact	0.83	0.79	neutral	0.79	neutral	0.43	6.89	deleterious	0.36	0.5	0.13	neutral	0.13	neutral	0.18	neutral	0.27	neutral	5	0.59	neutral	0.7	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.18	medium_impact	-0.46	medium_impact	0.24	0.8	24.53	32.23	0.51	N	0.27	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3585	3585	C	A	MI.11337	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	279	93	N	K	aaC/aaA	-0.01	0	0	benign	0.11	neutral	0.29	neutral	2.83	neutral	0.3	neutral	-0.8	low_impact	1.31	0.85	neutral	0.59	neutral	1.40	12.77	neutral	0.28	0.45	0.2	neutral	0.33	neutral	0.36	neutral	0.44	neutral	1	0.67	neutral	0.59	deleterious	-6	neutral	0.15	neutral	0.1	medium_impact	0.06	medium_impact	-0.04	medium_impact	0.28	0.8	24.53	32.23	0.39	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3585	3585	C	G	MI.11338	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	279	93	N	K	aaC/aaG	-0.01	0	0	benign	0.11	neutral	0.29	neutral	2.83	neutral	0.3	neutral	-0.8	low_impact	1.31	0.85	neutral	0.59	neutral	0.96	10.41	neutral	0.28	0.45	0.2	neutral	0.33	neutral	0.36	neutral	0.44	neutral	1	0.67	neutral	0.59	deleterious	-6	neutral	0.15	neutral	0.1	medium_impact	0.06	medium_impact	-0.04	medium_impact	0.28	0.8	24.53	32.23	0.39	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3586	3586	C	T	MI.11339	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	280	94	P	S	Ccc/Tcc	-2.77	0	0	benign	0.13	neutral	0.4	neutral	2.87	neutral	0.97	deleterious	-4.26	neutral_impact	0.45	0.87	neutral	0.89	neutral	2.38	18.68	deleterious	0.35	0.5	0.14	neutral	0.27	neutral	0.21	neutral	0.42	neutral	2	0.53	neutral	0.64	deleterious	-6	neutral	0.13	neutral	0.02	medium_impact	0.18	medium_impact	-0.8	medium_impact	0.05	0.8	22.96	23.16	0.38	N	0.62	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9059	9059	C	G	MI.1134	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	533	178	T	S	aCc/aGc	-0.1	0	0	benign	0.28	neutral	0.66	neutral	4.33	neutral	-1.8	neutral	-2.23	low_impact	0.9	0.81	neutral	0.59	neutral	3.57	23.10	deleterious	0.42	0.65	0.48	neutral	0.39	neutral	0.36	neutral	0.42	neutral	2	0.25	neutral	0.69	deleterious	-6	neutral	0.38	neutral	-0.37	medium_impact	0.45	medium_impact	-0.33	medium_impact	0.74	0.9	22.57	14.83	0.23	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3586	3586	C	G	MI.11340	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	280	94	P	A	Ccc/Gcc	-2.77	0	0	benign	0.12	neutral	0.5	neutral	2.85	neutral	0.8	deleterious	-4.69	neutral_impact	0.62	0.9	neutral	0.81	neutral	1.93	15.77	deleterious	0.26	0.45	0.17	neutral	0.29	neutral	0.4	neutral	0.43	neutral	1	0.41	neutral	0.69	deleterious	-6	neutral	0.13	neutral	0.06	medium_impact	0.28	medium_impact	-0.65	medium_impact	0.53	0.8	22.96	23.16	0.4	N	0.33	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3586	3586	C	A	MI.11341	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	280	94	P	T	Ccc/Acc	-2.77	0	0	possibly_damaging	0.74	neutral	0.39	neutral	2.82	neutral	0.34	deleterious	-4.31	low_impact	1.1	0.86	neutral	0.84	neutral	2.59	20.10	deleterious	0.22	0.45	0.17	neutral	0.39	neutral	0.24	neutral	0.45	neutral	1	0.76	neutral	0.33	neutral	-3	neutral	0.44	deleterious	-1.18	low_impact	0.17	medium_impact	-0.23	medium_impact	0.49	0.8	22.96	23.16	0.34	N	0.41	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3587	3587	C	G	MI.11342	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	281	94	P	R	cCc/cGc	0.22	0.04	0	probably_damaging	0.94	neutral	0.35	neutral	2.84	neutral	0.55	deleterious	-5.83	medium_impact	3.06	0.75	neutral	0.42	neutral	3.59	23.20	deleterious	0.12	0.4	0.21	neutral	0.69	disease	0.54	disease	0.66	disease	3	0.94	neutral	0.21	neutral	1	deleterious	0.64	deleterious	-1.87	low_impact	0.12	medium_impact	1.48	medium_impact	0.30	0.8	22.96	23.16	0.42	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3587	3587	C	T	MI.11343	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	281	94	P	L	cCc/cTc	0.22	0.04	0	possibly_damaging	0.83	neutral	0.65	neutral	2.79	neutral	-0.37	deleterious	-6.6	medium_impact	2.16	0.73	neutral	0.45	neutral	4.34	24.10	deleterious	0.2	0.45	0.25	neutral	0.58	disease	0.4	neutral	0.49	neutral	0	0.8	neutral	0.41	neutral	0	NA	0.58	deleterious	-1.4	low_impact	0.43	medium_impact	0.7	medium_impact	0.70	0.85	22.96	23.16	0.31	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3587	3587	C	A	MI.11344	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	281	94	P	H	cCc/cAc	0.22	0.04	0	probably_damaging	0.98	neutral	0.54	neutral	2.78	neutral	-0.77	deleterious	-5.96	medium_impact	2.63	0.75	neutral	0.39	neutral	3.97	23.60	deleterious	0.14	0.4	0.34	neutral	0.62	disease	0.35	neutral	0.49	neutral	0	0.97	neutral	0.28	neutral	1	deleterious	0.66	deleterious	-2.34	low_impact	0.31	medium_impact	1.11	medium_impact	0.28	0.8	22.96	23.16	0.28	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3589	3589	C	A	MI.11345	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	283	95	L	M	Ctg/Atg	-20	0	0	probably_damaging	1	neutral	0.3	neutral	2.59	neutral	-2.67	neutral	-0.96	medium_impact	1.96	0.83	neutral	0.62	neutral	2.52	19.60	deleterious	0.29	0.45	0.5	neutral	0.19	neutral	0.24	neutral	0.27	neutral	5	1	deleterious	0.15	neutral	1	deleterious	0.68	deleterious	-3.57	low_impact	0.07	medium_impact	0.52	medium_impact	0.66	0.8	59.43	10.55	0.43	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3589	3589	C	G	MI.11346	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	283	95	L	V	Ctg/Gtg	-20	0	0	probably_damaging	1	neutral	0.54	neutral	2.66	neutral	-1.04	neutral	-1.38	medium_impact	2.06	0.84	neutral	0.61	neutral	1.87	15.43	deleterious	0.24	0.45	0.31	neutral	0.19	neutral	0.27	neutral	0.36	neutral	3	1	deleterious	0.27	neutral	1	deleterious	0.66	deleterious	-3.57	low_impact	0.31	medium_impact	0.61	medium_impact	0.47	0.8	59.43	10.55	0.32	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3590	3590	T	G	MI.11347	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	284	95	L	R	cTg/cGg	-0.47	0	0	probably_damaging	1	neutral	0.32	neutral	2.52	deleterious	-3.96	deleterious	-4.8	high_impact	4.17	0.72	neutral	0.34	neutral	4.12	23.80	deleterious	0.04	0.35	0.67	disease	0.84	disease	0.74	disease	0.78	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.09	medium_impact	2.45	high_impact	0.12	0.8	59.43	10.55	0.43	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3590	3590	T	A	MI.11348	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	284	95	L	Q	cTg/cAg	-0.47	0	0	probably_damaging	1	neutral	0.28	neutral	2.52	deleterious	-4.18	deleterious	-4.57	medium_impact	2.62	0.74	neutral	0.45	neutral	4.12	23.80	deleterious	0.06	0.35	0.69	disease	0.69	disease	0.61	disease	0.58	disease	2	1	deleterious	0.14	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.05	medium_impact	1.1	medium_impact	0.16	0.8	59.43	10.55	0.31	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3590	3590	T	C	MI.11349	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	284	95	L	P	cTg/cCg	-0.47	0	0	probably_damaging	1	neutral	0.36	neutral	2.51	deleterious	-4.11	deleterious	-5.38	medium_impact	3.47	0.62	neutral	0.37	neutral	3.85	23.40	deleterious	0.05	0.35	0.32	neutral	0.83	disease	0.74	disease	0.77	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.14	medium_impact	1.84	medium_impact	0.20	0.8	59.43	10.55	0.39	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9059	9059	C	A	MI.1135	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	533	178	T	N	aCc/aAc	-0.1	0	0	possibly_damaging	0.75	neutral	0.29	neutral	4.3	deleterious	-3.27	deleterious	-3.55	low_impact	1.75	0.82	neutral	0.5	neutral	3.74	23.30	deleterious	0.32	0.65	0.69	disease	0.65	disease	0.52	disease	0.58	disease	2	0.81	neutral	0.27	neutral	-3	neutral	0.64	deleterious	-1.21	low_impact	0.07	medium_impact	0.4	medium_impact	0.71	0.9	22.57	14.83	0.3	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3592	3592	G	C	MI.11350	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	286	96	V	L	Gtc/Ctc	-8.28	0	0	benign	0.01	neutral	0.66	neutral	2.73	neutral	-0.47	neutral	-0.62	neutral_impact	-0.52	0.84	neutral	0.92	neutral	-0.02	2.42	deleterious	0.22	0.45	0.13	neutral	0.25	neutral	0.14	neutral	0.4	neutral	2	0.33	neutral	0.83	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.44	medium_impact	-1.64	low_impact	0.43	0.8	19.81	13.32	0.38	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3592	3592	G	T	MI.11351	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	286	96	V	F	Gtc/Ttc	-8.28	0	0	benign	0.38	neutral	0.71	neutral	2.6	neutral	-1.58	neutral	-2.11	neutral_impact	-0.63	0.79	neutral	0.66	neutral	1.96	15.95	deleterious	0.09	0.4	0.17	neutral	0.45	neutral	0.18	neutral	0.43	neutral	1	0.29	neutral	0.67	deleterious	-6	neutral	0.23	neutral	-0.55	medium_impact	0.49	medium_impact	-1.74	low_impact	0.29	0.8	19.81	13.32	0.3	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3592	3592	G	A	MI.11352	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	286	96	V	I	Gtc/Atc	-8.28	0	0	benign	0.01	neutral	0.4	neutral	2.72	neutral	-0.26	neutral	-0.36	neutral_impact	-1.3	0.68	neutral	0.93	neutral	-1.09	0.01	neutral	0.37	0.5	0.14	neutral	0.08	neutral	0.15	neutral	0.29	neutral	4	0.59	neutral	0.7	deleterious	-6	neutral	0.07	neutral	1.12	medium_impact	0.18	medium_impact	-2.32	low_impact	0.56	0.8	19.81	13.32	0.5	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3593	3593	T	C	MI.11353	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	287	96	V	A	gTc/gCc	-0.7	0	0.01	benign	0.01	neutral	0.51	neutral	2.66	neutral	0.02	neutral	0.12	neutral_impact	-1.45	0.85	neutral	0.92	neutral	-0.59	0.13	neutral	0.16	0.45	0.12	neutral	0.12	neutral	0.21	neutral	0.28	neutral	4	0.48	neutral	0.75	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.29	medium_impact	-2.45	low_impact	0.12	0.8	19.81	13.32	0.32	N	0.29	polymorphism	1	0.01	rs2854134	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3593	3593	T	G	MI.11354	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	287	96	V	G	gTc/gGc	-0.7	0	0.01	benign	0.26	neutral	0.33	neutral	2.57	neutral	-2.74	deleterious	-2.67	neutral_impact	0.63	0.74	neutral	0.52	neutral	2.17	17.29	deleterious	0.05	0.35	0.44	neutral	0.33	neutral	0.45	neutral	0.46	neutral	1	0.6	neutral	0.54	deleterious	-6	neutral	0.23	neutral	-0.32	medium_impact	0.1	medium_impact	-0.64	medium_impact	0.20	0.8	19.81	13.32	0.38	N	0.50	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3593	3593	T	A	MI.11355	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	287	96	V	D	gTc/gAc	-0.7	0	0.01	possibly_damaging	0.55	neutral	0.21	neutral	2.56	deleterious	-4.28	deleterious	-3	low_impact	1.22	0.76	neutral	0.48	neutral	4.06	23.70	deleterious	0.03	0.35	0.58	disease	0.58	disease	0.54	disease	0.63	disease	3	0.78	neutral	0.33	neutral	-3	neutral	0.46	deleterious	-0.83	medium_impact	-0.05	medium_impact	-0.12	medium_impact	0.03	0.8	19.81	13.32	0.32	N	0.49	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3595	3595	A	T	MI.11356	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	289	97	N	Y	Aac/Tac	-6.9	0	0	probably_damaging	0.99	neutral	1	neutral	2.64	deleterious	-3.45	deleterious	-4.96	medium_impact	1.96	0.71	neutral	0.1	damaging	3.64	23.20	deleterious	0.16	0.45	0.57	disease	0.64	disease	0.65	disease	0.66	disease	3	0.99	deleterious	0.51	deleterious	1	deleterious	0.74	deleterious	-2.62	low_impact	1.96	high_impact	0.52	medium_impact	0.12	0.8	15.09	25.31	0.18	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3595	3595	A	C	MI.11357	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	289	97	N	H	Aac/Cac	-6.9	0	0	probably_damaging	0.99	neutral	0.54	neutral	2.66	neutral	-2.55	deleterious	-2.8	medium_impact	2.55	0.8	neutral	0.11	damaging	3.02	22.30	deleterious	0.36	0.5	0.43	neutral	0.63	disease	0.55	disease	0.67	disease	3	0.99	deleterious	0.28	neutral	1	deleterious	0.71	deleterious	-2.62	low_impact	0.31	medium_impact	1.04	medium_impact	0.10	0.8	15.09	25.31	0.18	N	0.79	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3595	3595	A	G	MI.11358	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	289	97	N	D	Aac/Gac	-6.9	0	0	benign	0.17	neutral	0.2	neutral	2.98	neutral	1.03	neutral	1.16	neutral_impact	-0.56	0.81	neutral	0.7	neutral	1.04	10.89	neutral	0.54	0.6	0.13	neutral	0.08	neutral	0.23	neutral	0.26	neutral	5	0.77	neutral	0.52	deleterious	-6	neutral	0.17	neutral	-0.1	medium_impact	-0.06	medium_impact	-1.68	low_impact	0.28	0.8	15.09	25.31	0.41	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3596	3596	A	T	MI.11359	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	290	97	N	I	aAc/aTc	2.75	0.99	0	probably_damaging	0.98	neutral	0.39	neutral	2.65	deleterious	-3.1	deleterious	-5.32	medium_impact	2.39	0.69	neutral	0.12	damaging	4.39	24.10	deleterious	0.17	0.45	0.53	disease	0.74	disease	0.58	disease	0.7	disease	4	0.98	neutral	0.21	neutral	1	deleterious	0.74	deleterious	-2.34	low_impact	0.17	medium_impact	0.9	medium_impact	0.08	0.8	15.09	25.31	0.44	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9059	9059	C	T	MI.1136	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	533	178	T	I	aCc/aTc	-0.1	0	0	possibly_damaging	0.61	neutral	0.58	neutral	4.46	neutral	-0.85	deleterious	-3.13	low_impact	1.08	0.86	neutral	0.59	neutral	2.99	22.20	deleterious	0.28	0.65	0.43	neutral	0.66	disease	0.39	neutral	0.48	neutral	0	0.55	neutral	0.49	deleterious	-3	neutral	0.55	deleterious	-0.94	medium_impact	0.37	medium_impact	-0.17	medium_impact	0.75	0.9	22.57	14.83	0.2	N	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3596	3596	A	G	MI.11360	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	290	97	N	S	aAc/aGc	2.75	0.99	0	possibly_damaging	0.81	neutral	0.4	neutral	2.78	neutral	-0.23	neutral	-2.18	low_impact	1.27	0.85	neutral	0.16	damaging	3.48	23.10	deleterious	0.47	0.55	0.14	neutral	0.32	neutral	0.3	neutral	0.43	neutral	1	0.82	neutral	0.3	neutral	-3	neutral	0.62	deleterious	-1.34	low_impact	0.18	medium_impact	-0.08	medium_impact	0.17	0.8	15.09	25.31	0.44	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3596	3596	A	C	MI.11361	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	290	97	N	T	aAc/aCc	2.75	0.99	0	probably_damaging	0.94	neutral	0.39	neutral	2.71	neutral	-1.15	deleterious	-3.11	medium_impact	2.21	0.68	neutral	0.12	damaging	3.80	23.40	deleterious	0.28	0.45	0.29	neutral	0.51	disease	0.33	neutral	0.47	neutral	1	0.94	neutral	0.23	neutral	1	deleterious	0.67	deleterious	-1.87	low_impact	0.17	medium_impact	0.74	medium_impact	0.15	0.8	15.09	25.31	0.42	N	0.75	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3597	3597	C	A	MI.11362	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	291	97	N	K	aaC/aaA	6.42	1	0	probably_damaging	0.91	neutral	0.29	neutral	2.73	neutral	-0.91	deleterious	-3.1	medium_impact	2.9	0.84	neutral	0.12	damaging	4.43	24.20	deleterious	0.36	0.5	0.21	neutral	0.72	disease	0.65	disease	0.7	disease	4	0.93	neutral	0.19	neutral	1	deleterious	0.68	deleterious	-1.69	low_impact	0.06	medium_impact	1.34	medium_impact	0.28	0.8	15.09	25.31	0.55	P	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3597	3597	C	G	MI.11363	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	291	97	N	K	aaC/aaG	6.42	1	0	probably_damaging	0.91	neutral	0.29	neutral	2.73	neutral	-0.91	deleterious	-3.1	medium_impact	2.9	0.84	neutral	0.12	damaging	3.95	23.60	deleterious	0.36	0.5	0.21	neutral	0.72	disease	0.65	disease	0.7	disease	4	0.93	neutral	0.19	neutral	1	deleterious	0.68	deleterious	-1.69	low_impact	0.06	medium_impact	1.34	medium_impact	0.28	0.8	15.09	25.31	0.55	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3598	3598	C	A	MI.11364	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	292	98	L	I	Ctc/Atc	-1.16	0	0	benign	0.08	neutral	0.39	neutral	2.68	neutral	-0.8	neutral	-1.24	low_impact	1.24	0.88	neutral	0.81	neutral	3.01	22.30	deleterious	0.36	0.5	0.23	neutral	0.41	neutral	0.22	neutral	0.45	neutral	1	0.56	neutral	0.66	deleterious	-6	neutral	0.18	neutral	0.25	medium_impact	0.17	medium_impact	-0.11	medium_impact	0.47	0.8	27.36	38.79	0.42	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3598	3598	C	G	MI.11365	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	292	98	L	V	Ctc/Gtc	-1.16	0	0	benign	0.4	neutral	0.5	neutral	2.67	neutral	-0.9	neutral	-1.88	low_impact	1.92	0.73	neutral	0.68	neutral	3.31	22.90	deleterious	0.38	0.5	0.21	neutral	0.45	neutral	0.27	neutral	0.46	neutral	1	0.44	neutral	0.55	deleterious	-6	neutral	0.26	neutral	-0.59	medium_impact	0.28	medium_impact	0.49	medium_impact	0.49	0.8	27.36	38.79	0.41	N	0.31	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3598	3598	C	T	MI.11366	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	292	98	L	F	Ctc/Ttc	-1.16	0	0	benign	0.05	neutral	0.7	neutral	2.67	neutral	-0.92	deleterious	-2.92	neutral_impact	0.54	0.81	neutral	0.8	neutral	2.77	21.20	deleterious	0.3	0.45	0.22	neutral	0.24	neutral	0.2	neutral	0.43	neutral	1	0.22	neutral	0.83	deleterious	-6	neutral	0.17	neutral	0.45	medium_impact	0.48	medium_impact	-0.72	medium_impact	0.55	0.8	27.36	38.79	0.3	N	0.04	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3599	3599	T	A	MI.11367	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	293	98	L	H	cTc/cAc	-2.08	0	0	probably_damaging	0.98	neutral	0.54	neutral	2.51	deleterious	-4.05	deleterious	-5.45	medium_impact	3.26	0.73	neutral	0.51	neutral	4.08	23.70	deleterious	0.05	0.35	0.6	disease	0.78	disease	0.7	disease	0.75	disease	5	0.97	neutral	0.28	neutral	1	deleterious	0.77	deleterious	-2.34	low_impact	0.31	medium_impact	1.66	medium_impact	0.16	0.8	27.36	38.79	0.28	N	0.75	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3599	3599	T	C	MI.11368	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	293	98	L	P	cTc/cCc	-2.08	0	0	probably_damaging	0.96	neutral	0.21	neutral	2.53	deleterious	-3.34	deleterious	-5.47	medium_impact	2.61	0.6	damaging	0.42	neutral	3.84	23.40	deleterious	0.02	0.35	0.47	neutral	0.85	disease	0.73	disease	0.78	disease	6	0.98	neutral	0.13	neutral	1	deleterious	0.80	deleterious	-2.05	low_impact	-0.05	medium_impact	1.09	medium_impact	0.10	0.8	27.36	38.79	0.32	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3599	3599	T	G	MI.11369	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	293	98	L	R	cTc/cGc	-2.08	0	0	probably_damaging	0.93	neutral	0.35	neutral	2.52	deleterious	-3.38	deleterious	-4.63	high_impact	3.81	0.67	neutral	0.47	neutral	4.15	23.80	deleterious	0.02	0.35	0.5	neutral	0.87	disease	0.74	disease	0.79	disease	6	0.94	neutral	0.21	neutral	2	deleterious	0.78	deleterious	-1.81	low_impact	0.12	medium_impact	2.14	high_impact	0.10	0.8	27.36	38.79	0.43	N	0.82	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9061	9061	C	G	MI.1137	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	535	179	L	V	Cta/Gta	-13.29	0	0	benign	0.28	neutral	0.36	neutral	4.4	neutral	-1.05	neutral	-1.92	low_impact	1.25	0.83	neutral	0.68	neutral	0.69	8.79	deleterious	0.47	0.65	0.52	disease	0.35	neutral	0.42	neutral	0.36	neutral	3	0.56	neutral	0.54	deleterious	-6	neutral	0.33	neutral	-0.37	medium_impact	0.15	medium_impact	-0.03	medium_impact	0.70	0.9	44.25	7.93	0.36	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3601	3601	A	T	MI.11370	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	295	99	N	Y	Aac/Tac	-5.3	0	0	probably_damaging	1	neutral	1	neutral	2.54	deleterious	-3.95	deleterious	-7.32	high_impact	3.58	0.74	neutral	0.1	damaging	3.66	23.20	deleterious	0.14	0.4	0.59	disease	0.86	disease	0.72	disease	0.76	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.80	deleterious	-3.57	low_impact	1.96	high_impact	1.94	medium_impact	0.13	0.8	58.18	10.18	0.26	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3601	3601	A	C	MI.11371	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	295	99	N	H	Aac/Cac	-5.3	0	0	probably_damaging	1	neutral	0.52	neutral	2.56	deleterious	-3.14	deleterious	-4.57	high_impact	3.72	0.79	neutral	0.16	damaging	3.01	22.30	deleterious	0.42	0.5	0.47	neutral	0.83	disease	0.69	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.29	medium_impact	2.06	high_impact	0.14	0.8	58.18	10.18	0.25	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3601	3601	A	G	MI.11372	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	295	99	N	D	Aac/Gac	-5.3	0	0	probably_damaging	1	neutral	0.2	neutral	2.63	neutral	-1.47	deleterious	-4.56	medium_impact	2.77	0.79	neutral	0.14	damaging	3.74	23.30	deleterious	0.48	0.55	0.22	neutral	0.72	disease	0.66	disease	0.53	disease	1	1	deleterious	0.1	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	-0.06	medium_impact	1.23	medium_impact	0.28	0.8	58.18	10.18	0.33	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3602	3602	A	T	MI.11373	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	296	99	N	I	aAc/aTc	6.65	1	0	probably_damaging	1	neutral	0.38	neutral	2.55	deleterious	-3.52	deleterious	-8.23	high_impact	3.58	0.75	neutral	0.12	damaging	4.38	24.10	deleterious	0.14	0.4	0.54	disease	0.9	disease	0.66	disease	0.74	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.16	medium_impact	1.94	medium_impact	0.10	0.8	58.18	10.18	0.59	P	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3602	3602	A	G	MI.11374	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	296	99	N	S	aAc/aGc	6.65	1	0	probably_damaging	1	neutral	0.41	neutral	2.67	neutral	-0.99	deleterious	-4.52	medium_impact	2.61	0.75	neutral	0.19	damaging	3.51	23.10	deleterious	0.5	0.6	0.23	neutral	0.72	disease	0.44	neutral	0.49	neutral	0	1	deleterious	0.21	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.19	medium_impact	1.09	medium_impact	0.17	0.8	58.18	10.18	0.57	P	0.90	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3602	3602	A	C	MI.11375	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	296	99	N	T	aAc/aCc	6.65	1	0	probably_damaging	1	neutral	0.4	neutral	2.59	neutral	-2.1	deleterious	-5.46	medium_impact	3.33	0.7	neutral	0.17	damaging	3.80	23.40	deleterious	0.31	0.45	0.25	neutral	0.81	disease	0.67	disease	0.63	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.18	medium_impact	1.72	medium_impact	0.18	0.8	58.18	10.18	0.55	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3603	3603	C	A	MI.11376	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	297	99	N	K	aaC/aaA	8.49	1	0	probably_damaging	1	neutral	0.28	neutral	2.64	neutral	-1.36	deleterious	-5.47	medium_impact	2.38	0.72	neutral	0.1	damaging	4.42	24.20	deleterious	0.38	0.5	0.23	neutral	0.87	disease	0.67	disease	0.54	disease	1	1	deleterious	0.14	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.05	medium_impact	0.89	medium_impact	0.36	0.8	58.18	10.18	0.53	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3603	3603	C	G	MI.11377	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	297	99	N	K	aaC/aaG	8.49	1	0	probably_damaging	1	neutral	0.28	neutral	2.64	neutral	-1.36	deleterious	-5.47	medium_impact	2.38	0.72	neutral	0.1	damaging	3.95	23.60	deleterious	0.38	0.5	0.23	neutral	0.87	disease	0.67	disease	0.54	disease	1	1	deleterious	0.14	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.05	medium_impact	0.89	medium_impact	0.36	0.8	58.18	10.18	0.53	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3604	3604	C	A	MI.11378	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	298	100	L	M	Cta/Ata	-1.85	0	0	benign	0.31	neutral	0.25	neutral	2.48	neutral	-2.72	neutral	-1.52	medium_impact	2.42	0.84	neutral	0.74	neutral	2.74	21.00	deleterious	0.34	0.5	0.39	neutral	0.48	neutral	0.36	neutral	0.45	neutral	1	0.7	neutral	0.47	deleterious	-3	neutral	0.37	neutral	-0.43	medium_impact	0.01	medium_impact	0.93	medium_impact	0.67	0.85	52.52	9.59	0.43	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3604	3604	C	G	MI.11379	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	298	100	L	V	Cta/Gta	-1.85	0	0	possibly_damaging	0.64	neutral	0.52	neutral	2.63	neutral	-0.94	deleterious	-2.62	medium_impact	2.23	0.67	neutral	0.13	damaging	3.31	22.90	deleterious	0.29	0.45	0.19	neutral	0.51	disease	0.38	neutral	0.42	neutral	2	0.61	neutral	0.44	neutral	0	NA	0.56	deleterious	-0.99	medium_impact	0.29	medium_impact	0.76	medium_impact	0.49	0.8	52.52	9.59	0.27	N	0.84	polymorphism	1	0.09	rs28647976	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9061	9061	C	A	MI.1138	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	535	179	L	M	Cta/Ata	-13.29	0	0	benign	0.12	neutral	0.5	neutral	4.31	neutral	-2.17	neutral	-1.13	low_impact	1.21	0.9	neutral	0.63	neutral	0.80	9.46	deleterious	0.32	0.65	0.7	disease	0.24	neutral	0.25	neutral	0.58	disease	1	0.41	neutral	0.69	deleterious	-6	neutral	0.23	neutral	0.07	medium_impact	0.29	medium_impact	-0.06	medium_impact	0.64	0.9	44.25	7.93	0.39	N	0.96	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3605	3605	T	G	MI.11380	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	299	100	L	R	cTa/cGa	-0.93	0	0	probably_damaging	0.96	neutral	0.35	neutral	2.44	deleterious	-3.98	deleterious	-5.32	high_impact	4.43	0.74	neutral	0.11	damaging	4.09	23.70	deleterious	0.04	0.35	0.49	neutral	0.89	disease	0.75	disease	0.79	disease	6	0.96	neutral	0.2	neutral	2	deleterious	0.83	deleterious	-2.05	low_impact	0.12	medium_impact	2.68	high_impact	0.19	0.8	52.52	9.59	0.5	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3605	3605	T	A	MI.11381	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	299	100	L	Q	cTa/cAa	-0.93	0	0	probably_damaging	0.96	neutral	0.3	neutral	2.44	deleterious	-4.05	deleterious	-5.26	high_impact	4.43	0.72	neutral	0.12	damaging	4.00	23.60	deleterious	0.06	0.35	0.5	disease	0.83	disease	0.61	disease	0.68	disease	4	0.96	neutral	0.17	neutral	2	deleterious	0.77	deleterious	-2.05	low_impact	0.07	medium_impact	2.68	high_impact	0.20	0.8	52.52	9.59	0.42	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3605	3605	T	C	MI.11382	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	299	100	L	P	cTa/cCa	-0.93	0	0	probably_damaging	0.98	neutral	0.25	neutral	2.43	deleterious	-4.63	deleterious	-6.24	high_impact	4.43	0.75	neutral	0.12	damaging	3.81	23.40	deleterious	0.04	0.35	0.59	disease	0.84	disease	0.74	disease	0.77	disease	5	0.98	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-2.34	low_impact	0.01	medium_impact	2.68	high_impact	0.28	0.8	52.52	9.59	0.45	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3607	3607	G	A	MI.11383	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	301	101	G	S	Ggc/Agc	-0.93	0.02	0	possibly_damaging	0.78	neutral	0.44	neutral	2.6	neutral	-1.14	deleterious	-3.66	low_impact	0.86	0.84	neutral	0.84	neutral	2.74	21.00	deleterious	0.14	0.4	0.29	neutral	0.57	disease	0.39	neutral	0.44	neutral	1	0.77	neutral	0.33	neutral	-3	neutral	0.63	deleterious	-1.27	low_impact	0.22	medium_impact	-0.44	medium_impact	0.68	0.85	53.77	9.5	0.3	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3607	3607	G	T	MI.11384	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	301	101	G	C	Ggc/Tgc	-0.93	0.02	0	probably_damaging	1	neutral	0.18	neutral	2.41	deleterious	-4.96	deleterious	-6.65	high_impact	4.16	0.69	neutral	0.1	damaging	4.02	23.60	deleterious	0.05	0.35	0.84	disease	0.91	disease	0.66	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.09	medium_impact	2.44	high_impact	0.15	0.8	53.77	9.5	0.34	N	0.98	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3607	3607	G	C	MI.11385	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	301	101	G	R	Ggc/Cgc	-0.93	0.02	0	probably_damaging	1	neutral	0.35	neutral	2.44	deleterious	-3.19	deleterious	-5.93	high_impact	4.16	0.7	neutral	0.09	damaging	3.76	23.40	deleterious	0.04	0.35	0.44	neutral	0.91	disease	0.78	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.12	medium_impact	2.44	high_impact	0.34	0.8	53.77	9.5	0.46	N	0.99	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3608	3608	G	C	MI.11386	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	302	101	G	A	gGc/gCc	2.75	0.99	0	probably_damaging	0.95	neutral	0.52	neutral	2.54	neutral	-1.66	deleterious	-4.08	medium_impact	2.68	0.83	neutral	0.41	neutral	2.96	22.10	deleterious	0.16	0.45	0.3	neutral	0.69	disease	0.56	disease	0.5	neutral	0	0.94	neutral	0.29	neutral	1	deleterious	0.75	deleterious	-1.95	low_impact	0.29	medium_impact	1.15	medium_impact	0.29	0.8	53.77	9.5	0.43	N	0.76	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3608	3608	G	T	MI.11387	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	302	101	G	V	gGc/gTc	2.75	0.99	0	probably_damaging	0.99	neutral	0.53	neutral	2.44	deleterious	-3.24	deleterious	-6.74	high_impact	3.69	0.69	neutral	0.12	damaging	3.65	23.20	deleterious	0.05	0.35	0.56	disease	0.86	disease	0.67	disease	0.72	disease	4	0.99	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-2.62	low_impact	0.3	medium_impact	2.03	high_impact	0.13	0.8	53.77	9.5	0.44	N	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3608	3608	G	A	MI.11388	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	302	101	G	D	gGc/gAc	2.75	0.99	0	probably_damaging	0.99	neutral	0.22	neutral	2.46	neutral	-2.77	deleterious	-5.08	high_impact	3.6	0.75	neutral	0.11	damaging	3.80	23.40	deleterious	0.06	0.35	0.27	neutral	0.9	disease	0.75	disease	0.77	disease	5	0.99	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-2.62	low_impact	-0.03	medium_impact	1.96	medium_impact	0.09	0.8	53.77	9.5	0.5	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3610	3610	C	G	MI.11389	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	304	102	L	V	Ctc/Gtc	-4.84	0	0	benign	0.08	neutral	0.56	neutral	2.92	neutral	-0.66	neutral	-0.19	low_impact	1.4	0.88	neutral	0.94	neutral	1.50	13.32	neutral	0.26	0.45	0.15	neutral	0.17	neutral	0.31	neutral	0.3	neutral	4	0.37	neutral	0.74	deleterious	-6	neutral	0.13	neutral	0.25	medium_impact	0.33	medium_impact	0.03	medium_impact	0.66	0.8	29.25	35.19	0.36	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9062	9062	T	A	MI.1139	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	536	179	L	Q	cTa/cAa	-0.33	0	0	possibly_damaging	0.82	neutral	0.21	neutral	4.31	neutral	-2.99	deleterious	-4.1	medium_impact	2	0.82	neutral	0.41	neutral	4.00	23.60	deleterious	0.19	0.65	0.82	disease	0.62	disease	0.44	neutral	0.54	disease	1	0.89	neutral	0.2	neutral	0	NA	0.74	deleterious	-1.38	low_impact	-0.03	medium_impact	0.62	medium_impact	0.70	0.9	44.25	7.93	0.32	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3610	3610	C	T	MI.11390	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	304	102	L	F	Ctc/Ttc	-4.84	0	0	probably_damaging	0.91	neutral	0.75	neutral	2.61	neutral	-2.75	neutral	-2.41	low_impact	1.72	0.75	neutral	0.32	neutral	3.89	23.50	deleterious	0.21	0.45	0.25	neutral	0.54	disease	0.39	neutral	0.46	neutral	1	0.9	neutral	0.42	neutral	-2	neutral	0.66	deleterious	-1.69	low_impact	0.54	medium_impact	0.31	medium_impact	0.34	0.8	29.25	35.19	0.21	N	0.44	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3610	3610	C	A	MI.11391	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	304	102	L	I	Ctc/Atc	-4.84	0	0	benign	0.08	neutral	0.43	neutral	2.86	neutral	-0.64	neutral	0.35	neutral_impact	0.1	0.89	neutral	0.92	neutral	1.27	12.10	neutral	0.26	0.45	0.17	neutral	0.08	neutral	0.25	neutral	0.28	neutral	4	0.52	neutral	0.68	deleterious	-6	neutral	0.13	neutral	0.25	medium_impact	0.21	medium_impact	-1.1	low_impact	0.56	0.8	29.25	35.19	0.49	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3611	3611	T	G	MI.11392	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	305	102	L	R	cTc/cGc	-1.62	0	0	probably_damaging	0.95	neutral	0.33	neutral	2.59	deleterious	-4.26	deleterious	-4.54	high_impact	4.03	0.71	neutral	0.18	damaging	4.11	23.70	deleterious	0.01	0.35	0.59	disease	0.84	disease	0.7	disease	0.78	disease	6	0.96	neutral	0.19	neutral	2	deleterious	0.81	deleterious	-1.95	low_impact	0.1	medium_impact	2.33	high_impact	0.19	0.8	29.25	35.19	0.35	N	0.81	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3611	3611	T	A	MI.11393	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	305	102	L	H	cTc/cAc	-1.62	0	0	probably_damaging	0.98	neutral	0.51	neutral	2.57	deleterious	-4.81	deleterious	-4.93	high_impact	3.68	0.73	neutral	0.22	damaging	4.05	23.70	deleterious	0.03	0.35	0.67	disease	0.74	disease	0.61	disease	0.7	disease	4	0.98	deleterious	0.27	neutral	2	deleterious	0.78	deleterious	-2.34	low_impact	0.29	medium_impact	2.03	high_impact	0.31	0.8	29.25	35.19	0.31	N	0.68	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3611	3611	T	C	MI.11394	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	305	102	L	P	cTc/cCc	-1.62	0	0	probably_damaging	0.98	neutral	0.21	neutral	2.58	deleterious	-4.39	deleterious	-4.8	medium_impact	3.48	0.7	neutral	0.18	damaging	3.81	23.40	deleterious	0.02	0.35	0.67	disease	0.87	disease	0.71	disease	0.78	disease	6	0.98	deleterious	0.12	neutral	1	deleterious	0.85	deleterious	-2.34	low_impact	-0.05	medium_impact	1.85	medium_impact	0.36	0.8	29.25	35.19	0.3	N	0.90	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3613	3613	C	A	MI.11395	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	307	103	L	M	Cta/Ata	-8.05	0	0	possibly_damaging	0.76	neutral	0.23	neutral	2.07	deleterious	-3.77	neutral	-1.76	medium_impact	3.04	0.78	neutral	0.27	damaging	3.62	23.20	deleterious	0.09	0.4	0.55	disease	0.54	disease	0.44	neutral	0.47	neutral	1	0.85	neutral	0.24	neutral	0	NA	0.65	deleterious	-1.22	low_impact	-0.02	medium_impact	1.47	medium_impact	0.44	0.8	60.69	9.64	0.32	N	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3613	3613	C	G	MI.11396	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	307	103	L	V	Cta/Gta	-8.05	0	0	possibly_damaging	0.9	neutral	0.51	neutral	2.12	deleterious	-3.06	deleterious	-2.69	medium_impact	3.19	0.79	neutral	0.13	damaging	3.30	22.90	deleterious	0.09	0.35	0.39	neutral	0.56	disease	0.59	disease	0.56	disease	1	0.89	neutral	0.31	neutral	0	NA	0.70	deleterious	-1.65	low_impact	0.29	medium_impact	1.6	medium_impact	0.52	0.8	60.69	9.64	0.2	N	0.84	polymorphism	1	0.23	rs28531858	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3614	3614	T	G	MI.11397	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	308	103	L	R	cTa/cGa	-0.47	0	0	probably_damaging	0.98	neutral	0.36	neutral	2.01	deleterious	-6.02	deleterious	-5.46	high_impact	4.84	0.76	neutral	0.11	damaging	4.11	23.70	deleterious	0.02	0.35	0.83	disease	0.88	disease	0.76	disease	0.82	disease	6	0.99	deleterious	0.19	neutral	2	deleterious	0.88	deleterious	-2.34	low_impact	0.14	medium_impact	3.04	high_impact	0.17	0.8	60.69	9.64	0.7	P	1.00	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3614	3614	T	A	MI.11398	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	308	103	L	Q	cTa/cAa	-0.47	0	0	probably_damaging	0.99	neutral	0.31	neutral	2.01	deleterious	-5.96	deleterious	-5.45	high_impact	4.84	0.76	neutral	0.12	damaging	3.99	23.60	deleterious	0.02	0.35	0.83	disease	0.84	disease	0.65	disease	0.74	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-2.62	low_impact	0.08	medium_impact	3.04	high_impact	0.26	0.8	60.69	9.64	0.62	P	0.99	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3614	3614	T	C	MI.11399	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	308	103	L	P	cTa/cCa	-0.47	0	0	probably_damaging	1	neutral	0.22	neutral	2.01	deleterious	-6.6	deleterious	-6.38	high_impact	4.04	0.78	neutral	0.14	damaging	3.81	23.40	deleterious	0.02	0.35	0.8	disease	0.84	disease	0.76	disease	0.81	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.03	medium_impact	2.34	high_impact	0.27	0.8	60.69	9.64	0.36	N	1.00	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8579	8579	C	G	MI.114	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	53	18	P	R	cCc/cGc	1.29	0.83	0	probably_damaging	1	deleterious	0.01	neutral	4.59	neutral	-0.09	deleterious	-7.67	high_impact	3.8	0.73	neutral	0.44	neutral	3.34	22.90	deleterious	0.25	0.65	0.72	disease	0.92	disease	0.78	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-0.84	medium_impact	2.16	high_impact	0.75	0.9	21.24	15.57	0.38	N	0.93	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9062	9062	T	C	MI.1140	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	536	179	L	P	cTa/cCa	-0.33	0	0	probably_damaging	0.9	neutral	0.31	neutral	4.32	deleterious	-3.45	deleterious	-4.65	low_impact	0.97	0.73	neutral	0.28	neutral	3.90	23.50	deleterious	0.17	0.65	0.42	neutral	0.73	disease	0.59	disease	0.55	disease	1	0.92	neutral	0.21	neutral	-2	neutral	0.74	deleterious	-1.66	low_impact	0.1	medium_impact	-0.27	medium_impact	0.57	0.9	44.25	7.93	0.25	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	COSM1155691	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3616	3616	T	G	MI.11400	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	310	104	F	V	Ttt/Gtt	-1.62	0	0	probably_damaging	1	neutral	0.58	neutral	2.55	neutral	-1.69	deleterious	-6.32	medium_impact	2.81	0.68	neutral	0.17	damaging	3.82	23.40	deleterious	0.11	0.4	0.18	neutral	0.86	disease	0.59	disease	0.65	disease	3	1	deleterious	0.29	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.35	medium_impact	1.27	medium_impact	0.28	0.8	59.43	10.27	0.27	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3616	3616	T	A	MI.11401	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	310	104	F	I	Ttt/Att	-1.62	0	0	probably_damaging	1	neutral	0.49	neutral	2.52	neutral	-2.07	deleterious	-5.41	medium_impact	2.88	0.76	neutral	0.22	damaging	4.26	23.90	deleterious	0.13	0.4	0.27	neutral	0.86	disease	0.57	disease	0.65	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.27	medium_impact	1.33	medium_impact	0.44	0.8	59.43	10.27	0.34	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3616	3616	T	C	MI.11402	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	310	104	F	L	Ttt/Ctt	-1.62	0	0	probably_damaging	1	neutral	0.97	neutral	2.72	neutral	-0.38	deleterious	-5.41	medium_impact	2.31	0.75	neutral	0.19	damaging	3.85	23.40	deleterious	0.16	0.45	0.16	neutral	0.82	disease	0.42	neutral	0.5	neutral	0	1	deleterious	0.49	deleterious	1	deleterious	0.70	deleterious	-3.57	low_impact	1.12	medium_impact	0.83	medium_impact	0.49	0.8	59.43	10.27	0.28	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3617	3617	T	A	MI.11403	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	311	104	F	Y	tTt/tAt	3.44	1	0	probably_damaging	1	neutral	1	neutral	2.57	neutral	-1.5	deleterious	-2.72	medium_impact	1.97	0.79	neutral	0.19	damaging	4.21	23.90	deleterious	0.17	0.45	0.25	neutral	0.71	disease	0.44	neutral	0.49	neutral	0	1	deleterious	0.5	deleterious	1	deleterious	0.73	deleterious	-3.57	low_impact	1.96	high_impact	0.53	medium_impact	0.51	0.8	59.43	10.27	0.38	N	0.88	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3617	3617	T	C	MI.11404	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	311	104	F	S	tTt/tCt	3.44	1	0	probably_damaging	1	neutral	0.49	neutral	2.46	deleterious	-3.38	deleterious	-7.26	high_impact	3.65	0.72	neutral	0.21	damaging	4.20	23.90	deleterious	0.05	0.35	0.4	neutral	0.88	disease	0.62	disease	0.66	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.27	medium_impact	2	medium_impact	0.33	0.8	59.43	10.27	0.49	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3617	3617	T	G	MI.11405	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	311	104	F	C	tTt/tGt	3.44	1	0	probably_damaging	1	neutral	0.17	neutral	2.43	deleterious	-4.82	deleterious	-7.27	high_impact	3.85	0.74	neutral	0.16	damaging	4.00	23.60	deleterious	0.05	0.35	0.6	disease	0.9	disease	0.6	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	-0.11	medium_impact	2.17	high_impact	0.17	0.8	59.43	10.27	0.55	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3618	3618	T	A	MI.11406	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	312	104	F	L	ttT/ttA	7.34	1	0	probably_damaging	1	neutral	0.97	neutral	2.72	neutral	-0.38	deleterious	-5.41	medium_impact	2.31	0.75	neutral	0.19	damaging	4.36	24.10	deleterious	0.16	0.45	0.16	neutral	0.82	disease	0.42	neutral	0.5	neutral	0	1	deleterious	0.49	deleterious	1	deleterious	0.70	deleterious	-3.57	low_impact	1.12	medium_impact	0.83	medium_impact	0.49	0.8	59.43	10.27	0.46	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3618	3618	T	G	MI.11407	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	312	104	F	L	ttT/ttG	7.34	1	0	probably_damaging	1	neutral	0.97	neutral	2.72	neutral	-0.38	deleterious	-5.41	medium_impact	2.31	0.75	neutral	0.19	damaging	4.25	23.90	deleterious	0.16	0.45	0.16	neutral	0.82	disease	0.42	neutral	0.5	neutral	0	1	deleterious	0.49	deleterious	1	deleterious	0.70	deleterious	-3.57	low_impact	1.12	medium_impact	0.83	medium_impact	0.49	0.8	59.43	10.27	0.46	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3619	3619	A	G	MI.11408	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	313	105	I	V	Att/Gtt	-3.23	0	0	benign	0.04	neutral	0.45	neutral	2.75	neutral	-0.21	neutral	-0.52	low_impact	1.5	0.89	neutral	0.79	neutral	1.78	14.87	neutral	0.28	0.45	0.21	neutral	0.34	neutral	0.35	neutral	0.44	neutral	1	0.52	neutral	0.71	deleterious	-6	neutral	0.12	neutral	0.55	medium_impact	0.23	medium_impact	0.12	medium_impact	0.48	0.8	24.21	35.91	0.38	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3619	3619	A	T	MI.11409	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	313	105	I	F	Att/Ttt	-3.23	0	0	possibly_damaging	0.78	neutral	0.76	neutral	2.74	neutral	-1.63	deleterious	-2.64	low_impact	1.15	0.76	neutral	0.57	neutral	3.63	23.20	deleterious	0.16	0.45	0.25	neutral	0.57	disease	0.33	neutral	0.44	neutral	1	0.74	neutral	0.49	deleterious	-3	neutral	0.58	deleterious	-1.27	low_impact	0.56	medium_impact	-0.18	medium_impact	0.56	0.8	24.21	35.91	0.28	N	0.74	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9062	9062	T	G	MI.1141	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	536	179	L	R	cTa/cGa	-0.33	0	0	possibly_damaging	0.82	neutral	0.23	neutral	4.34	deleterious	-3.83	deleterious	-4.2	medium_impact	2.7	0.81	neutral	0.32	neutral	4.11	23.70	deleterious	0.19	0.65	0.8	disease	0.8	disease	0.59	disease	0.75	disease	5	0.88	neutral	0.21	neutral	0	NA	0.78	deleterious	-1.38	low_impact	-0.01	medium_impact	1.22	medium_impact	0.71	0.9	44.25	7.93	0.29	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3619	3619	A	C	MI.11410	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	313	105	I	L	Att/Ctt	-3.23	0	0	benign	0.14	neutral	1	neutral	2.84	neutral	-0.44	neutral	-0.49	low_impact	0.82	0.88	neutral	0.91	neutral	2.48	19.35	deleterious	0.18	0.45	0.15	neutral	0.51	disease	0.29	neutral	0.44	neutral	1	0.13	neutral	0.93	deleterious	-6	neutral	0.16	neutral	-0.01	medium_impact	1.96	high_impact	-0.47	medium_impact	0.46	0.8	24.21	35.91	0.27	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3620	3620	T	G	MI.11411	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	314	105	I	S	aTt/aGt	0.22	0.01	0	possibly_damaging	0.56	neutral	0.4	neutral	2.62	neutral	-2.76	deleterious	-4.16	medium_impact	3.29	0.72	neutral	0.52	neutral	4.07	23.70	deleterious	0.04	0.35	0.43	neutral	0.85	disease	0.57	disease	0.73	disease	5	0.62	neutral	0.42	neutral	0	NA	0.47	deleterious	-0.85	medium_impact	0.18	medium_impact	1.69	medium_impact	0.28	0.8	24.21	35.91	0.38	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3620	3620	T	A	MI.11412	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	314	105	I	N	aTt/aAt	0.22	0.01	0	possibly_damaging	0.87	neutral	0.41	neutral	2.59	deleterious	-4.21	deleterious	-5.09	high_impact	3.98	0.73	neutral	0.49	neutral	4.22	23.90	deleterious	0.08	0.35	0.61	disease	0.85	disease	0.59	disease	0.73	disease	5	0.87	neutral	0.27	neutral	1	deleterious	0.71	deleterious	-1.53	low_impact	0.19	medium_impact	2.29	high_impact	0.29	0.8	24.21	35.91	0.4	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3620	3620	T	C	MI.11413	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	314	105	I	T	aTt/aCt	0.22	0.01	0	benign	0.06	neutral	0.32	neutral	2.64	neutral	-2.37	deleterious	-3.4	medium_impact	2.65	0.87	neutral	0.62	neutral	3.16	22.60	deleterious	0.09	0.35	0.37	neutral	0.67	disease	0.57	disease	0.69	disease	4	0.65	neutral	0.63	deleterious	-3	neutral	0.19	neutral	0.37	medium_impact	0.09	medium_impact	1.13	medium_impact	0.28	0.8	24.21	35.91	0.39	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3621	3621	T	G	MI.11414	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	315	105	I	M	atT/atG	5.5	0.86	0.01	benign	0.16	neutral	0.28	neutral	2.65	neutral	-2.44	neutral	-0.52	low_impact	1.17	0.8	neutral	0.95	neutral	1.73	14.61	neutral	0.19	0.45	0.3	neutral	0.38	neutral	0.35	neutral	0.45	neutral	1	0.67	neutral	0.56	deleterious	-6	neutral	0.18	neutral	-0.08	medium_impact	0.05	medium_impact	-0.17	medium_impact	0.54	0.8	24.21	35.91	0.5	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3621	3621	T	A	MI.11415	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	315	105	I	M	atT/atA	5.5	0.86	0.01	benign	0.16	neutral	0.28	neutral	2.65	neutral	-2.44	neutral	-0.52	low_impact	1.17	0.8	neutral	0.95	neutral	2.09	16.79	deleterious	0.19	0.45	0.3	neutral	0.38	neutral	0.35	neutral	0.45	neutral	1	0.67	neutral	0.56	deleterious	-6	neutral	0.18	neutral	-0.08	medium_impact	0.05	medium_impact	-0.17	medium_impact	0.54	0.8	24.21	35.91	0.5	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3622	3622	C	A	MI.11416	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	316	106	L	M	Cta/Ata	-4.84	0	0	probably_damaging	1	neutral	0.12	neutral	2.22	deleterious	-3.02	neutral	-1.69	medium_impact	2	0.71	neutral	0.15	damaging	3.56	23.10	deleterious	0.27	0.45	0.4	neutral	0.42	neutral	0.38	neutral	0.44	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	-0.21	medium_impact	0.56	medium_impact	0.56	0.8	59.12	10.61	0.34	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3622	3622	C	G	MI.11417	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	316	106	L	V	Cta/Gta	-4.84	0	0	probably_damaging	1	neutral	0.27	neutral	2.25	neutral	-2.62	neutral	-2.47	high_impact	3.6	0.67	neutral	0.08	damaging	3.30	22.90	deleterious	0.24	0.45	0.29	neutral	0.58	disease	0.55	disease	0.54	disease	1	1	deleterious	0.14	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.03	medium_impact	1.96	medium_impact	0.54	0.8	59.12	10.61	0.32	N	0.84	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3623	3623	T	G	MI.11418	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	317	106	L	R	cTa/cGa	-0.7	0	0	probably_damaging	1	neutral	0.12	neutral	2.13	deleterious	-5.71	deleterious	-5.4	high_impact	4.64	0.52	damaging	0.05	damaging	4.09	23.70	deleterious	0.03	0.35	0.59	disease	0.89	disease	0.74	disease	0.76	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.21	medium_impact	2.86	high_impact	0.18	0.8	59.12	10.61	0.45	N	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3623	3623	T	C	MI.11419	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	317	106	L	P	cTa/cCa	-0.7	0	0	probably_damaging	1	neutral	0.09	neutral	2.13	deleterious	-6.24	deleterious	-6.26	high_impact	4.64	0.48	damaging	0.06	damaging	3.80	23.40	deleterious	0.03	0.35	0.47	neutral	0.87	disease	0.74	disease	0.75	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.29	medium_impact	2.86	high_impact	0.31	0.8	59.12	10.61	0.47	N	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9064	9064	G	A	MI.1142	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	538	180	A	T	Gca/Aca	-1.49	0	0	benign	0.03	neutral	0.45	neutral	4.44	neutral	0.58	neutral	-0.54	neutral_impact	0.03	0.93	neutral	0.92	neutral	0.82	9.62	deleterious	0.49	0.65	0.25	neutral	0.28	neutral	0.3	neutral	0.44	neutral	1	0.52	neutral	0.71	deleterious	-6	neutral	0.14	neutral	0.68	medium_impact	0.24	medium_impact	-1.07	low_impact	0.81	0.9	19.91	14.58	0.32	N	0.61	polymorphism	1	0.01	rs386420013	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3623	3623	T	A	MI.11420	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	317	106	L	Q	cTa/cAa	-0.7	0	0	probably_damaging	1	neutral	0.1	neutral	2.13	deleterious	-5.67	deleterious	-5.38	high_impact	4.64	0.56	damaging	0.06	damaging	3.93	23.50	deleterious	0.04	0.35	0.61	disease	0.84	disease	0.62	disease	0.7	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	-0.26	medium_impact	2.86	high_impact	0.31	0.8	59.12	10.61	0.42	N	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3625	3625	G	A	MI.11421	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	319	107	A	T	Gcc/Acc	-0.47	0.49	0	probably_damaging	1	neutral	0.21	neutral	2.48	deleterious	-3.05	deleterious	-3.08	high_impact	3.56	0.8	neutral	0.23	damaging	4.11	23.70	deleterious	0.12	0.4	0.41	neutral	0.76	disease	0.41	neutral	0.49	neutral	0	1	deleterious	0.11	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.05	medium_impact	1.92	medium_impact	0.77	0.85	56.92	9.27	0.38	N	0.79	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3625	3625	G	C	MI.11422	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	319	107	A	P	Gcc/Ccc	-0.47	0.49	0	probably_damaging	1	neutral	0.09	neutral	2.42	deleterious	-5.13	deleterious	-4.21	high_impact	4.46	0.73	neutral	0.14	damaging	3.71	23.30	deleterious	0.03	0.35	0.68	disease	0.93	disease	0.72	disease	0.8	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.29	medium_impact	2.71	high_impact	0.60	0.8	56.92	9.27	0.49	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3625	3625	G	T	MI.11423	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	319	107	A	S	Gcc/Tcc	-0.47	0.49	0	probably_damaging	1	neutral	0.24	neutral	2.49	deleterious	-3.19	neutral	-2.08	medium_impact	2.11	0.84	neutral	0.69	neutral	3.55	23.10	deleterious	0.24	0.45	0.45	neutral	0.79	disease	0.39	neutral	0.5	neutral	0	1	deleterious	0.12	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	-0.01	medium_impact	0.65	medium_impact	0.50	0.8	56.92	9.27	0.37	N	0.32	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3626	3626	C	A	MI.11424	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	320	107	A	D	gCc/gAc	3.9	1	0	probably_damaging	1	neutral	0.09	neutral	2.42	deleterious	-5.14	deleterious	-4.93	high_impact	4.46	0.79	neutral	0.09	damaging	4.53	24.30	deleterious	0.02	0.35	0.71	disease	0.94	disease	0.7	disease	0.84	disease	7	1	deleterious	0.05	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.29	medium_impact	2.71	high_impact	0.34	0.8	56.92	9.27	0.58	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3626	3626	C	G	MI.11425	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	320	107	A	G	gCc/gGc	3.9	1	0	probably_damaging	1	neutral	0.44	neutral	2.48	neutral	-2.41	deleterious	-3.36	medium_impact	2.73	0.77	neutral	0.15	damaging	3.88	23.50	deleterious	0.22	0.45	0.6	disease	0.81	disease	0.4	neutral	0.53	disease	1	1	deleterious	0.22	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.22	medium_impact	1.2	medium_impact	0.70	0.85	56.92	9.27	0.46	N	0.68	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3626	3626	C	T	MI.11426	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	320	107	A	V	gCc/gTc	3.9	1	0	probably_damaging	1	neutral	0.43	neutral	2.49	neutral	-2.26	deleterious	-3.5	medium_impact	2.54	0.7	neutral	0.1	damaging	4.34	24.00	deleterious	0.11	0.4	0.29	neutral	0.85	disease	0.57	disease	0.64	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.21	medium_impact	1.03	medium_impact	0.75	0.85	56.92	9.27	0.48	N	0.82	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3628	3628	A	G	MI.11427	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	322	108	T	A	Acc/Gcc	-12.88	0	0	benign	0.01	neutral	0.18	neutral	2.83	neutral	0.51	neutral	-0.4	low_impact	0.86	0.84	neutral	0.85	neutral	1.92	15.72	deleterious	0.28	0.45	0.17	neutral	0.34	neutral	0.4	neutral	0.44	neutral	1	0.82	neutral	0.59	deleterious	-6	neutral	0.14	neutral	1.12	medium_impact	-0.09	medium_impact	-0.44	medium_impact	0.29	0.8	27.36	41.48	0.39	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3628	3628	A	T	MI.11428	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	322	108	T	S	Acc/Tcc	-12.88	0	0	benign	0.02	neutral	0.29	neutral	2.78	neutral	-0.7	neutral	-1.07	low_impact	1.4	0.69	neutral	0.69	neutral	1.92	15.69	deleterious	0.33	0.5	0.27	neutral	0.4	neutral	0.46	neutral	0.45	neutral	1	0.7	neutral	0.64	deleterious	-6	neutral	0.16	neutral	0.84	medium_impact	0.06	medium_impact	0.03	medium_impact	0.47	0.8	27.36	41.48	0.47	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3628	3628	A	C	MI.11429	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	322	108	T	P	Acc/Ccc	-12.88	0	0	possibly_damaging	0.55	neutral	0.06	neutral	2.74	neutral	-2.31	neutral	-2.1	medium_impact	1.96	0.6	neutral	0.45	neutral	3.49	23.10	deleterious	0.05	0.35	0.48	neutral	0.83	disease	0.63	disease	0.78	disease	6	0.94	neutral	0.26	neutral	0	NA	0.68	deleterious	-0.83	medium_impact	-0.4	medium_impact	0.52	medium_impact	0.32	0.8	27.36	41.48	0.34	N	0.61	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9064	9064	G	C	MI.1143	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	538	180	A	P	Gca/Cca	-1.49	0	0	possibly_damaging	0.83	neutral	0.19	neutral	4.3	neutral	-2.36	deleterious	-2.73	low_impact	1.68	0.76	neutral	0.35	neutral	3.78	23.40	deleterious	0.13	0.65	0.81	disease	0.81	disease	0.63	disease	0.78	disease	6	0.9	neutral	0.18	neutral	-3	neutral	0.82	deleterious	-1.41	low_impact	-0.06	medium_impact	0.34	medium_impact	0.88	0.9	19.91	14.58	0.24	N	0.97	polymorphism	1	0.05	rs386420013	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3629	3629	C	T	MI.11430	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	323	108	T	I	aCc/aTc	-0.24	0	0	benign	0.01	neutral	0.38	neutral	2.96	neutral	2.02	neutral	2.11	neutral_impact	-1.52	0.84	neutral	0.8	neutral	0.85	9.78	deleterious	0.1	0.4	0.14	neutral	0.32	neutral	0.26	neutral	0.43	neutral	1	0.61	neutral	0.69	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	0.16	medium_impact	-2.52	low_impact	0.43	0.8	27.36	41.48	0.32	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3629	3629	C	A	MI.11431	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	323	108	T	N	aCc/aAc	-0.24	0	0	benign	0.38	neutral	0.15	neutral	2.75	neutral	-1.94	neutral	-2.04	medium_impact	1.96	0.56	damaging	0.65	neutral	3.20	22.70	deleterious	0.24	0.45	0.44	neutral	0.62	disease	0.51	disease	0.54	disease	1	0.82	neutral	0.39	neutral	-3	neutral	0.41	neutral	-0.55	medium_impact	-0.15	medium_impact	0.52	medium_impact	0.47	0.8	27.36	41.48	0.39	N	0.50	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3629	3629	C	G	MI.11432	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	323	108	T	S	aCc/aGc	-0.24	0	0	benign	0.02	neutral	0.29	neutral	2.78	neutral	-0.7	neutral	-1.07	low_impact	1.4	0.69	neutral	0.69	neutral	1.62	13.97	neutral	0.33	0.5	0.27	neutral	0.4	neutral	0.46	neutral	0.45	neutral	1	0.7	neutral	0.64	deleterious	-6	neutral	0.16	neutral	0.84	medium_impact	0.06	medium_impact	0.03	medium_impact	0.47	0.8	27.36	41.48	0.48	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3631	3631	T	A	MI.11433	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	325	109	S	T	Tct/Act	-2.77	0	0	possibly_damaging	0.85	neutral	0.14	neutral	2.52	neutral	-1.85	deleterious	-2.77	medium_impact	2.42	0.66	neutral	0.13	damaging	3.70	23.30	deleterious	0.3	0.45	0.28	neutral	0.47	neutral	0.49	neutral	0.41	neutral	2	0.93	neutral	0.15	neutral	0	NA	0.63	deleterious	-1.46	low_impact	-0.17	medium_impact	0.93	medium_impact	0.49	0.8	56.29	9.64	0.39	N	0.60	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3631	3631	T	G	MI.11434	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	325	109	S	A	Tct/Gct	-2.77	0	0	possibly_damaging	0.64	neutral	0.19	neutral	2.54	neutral	-1.6	deleterious	-2.77	medium_impact	3	0.71	neutral	0.18	damaging	3.60	23.20	deleterious	0.28	0.45	0.26	neutral	0.65	disease	0.63	disease	0.56	disease	1	0.83	neutral	0.28	neutral	0	NA	0.56	deleterious	-0.99	medium_impact	-0.08	medium_impact	1.43	medium_impact	0.40	0.8	56.29	9.64	0.36	N	0.39	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3631	3631	T	C	MI.11435	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	325	109	S	P	Tct/Cct	-2.77	0	0	probably_damaging	0.98	neutral	0.05	neutral	2.41	deleterious	-4.03	deleterious	-4.63	high_impact	4.29	0.69	neutral	0.13	damaging	3.87	23.50	deleterious	0.05	0.35	0.61	disease	0.9	disease	0.8	disease	0.78	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.84	deleterious	-2.34	low_impact	-0.44	medium_impact	2.56	high_impact	0.31	0.8	56.29	9.64	0.5	N	0.94	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3632	3632	C	G	MI.11436	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	326	109	S	C	tCt/tGt	5.5	1	0	probably_damaging	0.98	neutral	0.25	neutral	2.4	deleterious	-4.7	deleterious	-4.63	high_impact	4.29	0.7	neutral	0.11	damaging	3.51	23.10	deleterious	0.08	0.35	0.62	disease	0.85	disease	0.68	disease	0.72	disease	4	0.99	deleterious	0.14	neutral	2	deleterious	0.78	deleterious	-2.34	low_impact	0.01	medium_impact	2.56	high_impact	0.24	0.8	56.29	9.64	0.65	P	0.65	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3632	3632	C	A	MI.11437	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	326	109	S	Y	tCt/tAt	5.5	1	0	probably_damaging	0.97	neutral	0.29	neutral	2.41	deleterious	-4.34	deleterious	-5.55	high_impact	3.94	0.7	neutral	0.12	damaging	3.93	23.50	deleterious	0.06	0.35	0.49	neutral	0.9	disease	0.72	disease	0.75	disease	5	0.97	neutral	0.16	neutral	2	deleterious	0.79	deleterious	-2.17	low_impact	0.06	medium_impact	2.25	high_impact	0.20	0.8	56.29	9.64	0.63	P	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3632	3632	C	T	MI.11438	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	326	109	S	F	tCt/tTt	5.5	1	0	probably_damaging	0.92	neutral	0.73	neutral	2.41	deleterious	-4.09	deleterious	-5.55	medium_impact	3.44	0.61	neutral	0.11	damaging	4.09	23.70	deleterious	0.06	0.35	0.29	neutral	0.92	disease	0.68	disease	0.74	disease	5	0.9	neutral	0.41	neutral	1	deleterious	0.73	deleterious	-1.75	low_impact	0.52	medium_impact	1.82	medium_impact	0.16	0.8	56.29	9.64	0.47	N	0.93	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	C3632T	LHON	+	-	Reported	1	.	P	P	damaging
chrM	3634	3634	A	G	MI.11439	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	328	110	S	G	Agc/Ggc	-5.07	0	0	probably_damaging	1	neutral	0.19	neutral	2.31	neutral	-2.09	deleterious	-3.39	low_impact	1.82	0.8	neutral	0.76	neutral	3.45	23.00	deleterious	0.16	0.45	0.29	neutral	0.58	disease	0.58	disease	0.42	neutral	2	1	deleterious	0.1	neutral	-2	neutral	0.70	deleterious	-3.57	low_impact	-0.08	medium_impact	0.4	medium_impact	0.39	0.8	16.35	25.33	0.34	N	0.24	polymorphism	1	0.21	rs878880889	.	.	.	.	.	.	.	.	A3634G	LHON	+	-	Reported	1	N	P	N,P	neutral
chrM	9064	9064	G	T	MI.1144	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	538	180	A	S	Gca/Tca	-1.49	0	0	benign	0.39	neutral	0.8	neutral	4.41	neutral	0.17	neutral	-1.37	neutral_impact	0.03	0.85	neutral	0.67	neutral	2.04	16.46	deleterious	0.48	0.65	0.38	neutral	0.36	neutral	0.31	neutral	0.47	neutral	1	0.27	neutral	0.71	deleterious	-6	neutral	0.37	neutral	-0.57	medium_impact	0.63	medium_impact	-1.07	low_impact	0.87	0.9	19.91	14.58	0.23	N	0.50	polymorphism	1	0.02	rs386420013	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3634	3634	A	T	MI.11440	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	328	110	S	C	Agc/Tgc	-5.07	0	0	probably_damaging	1	neutral	0.22	neutral	2.13	deleterious	-5.55	deleterious	-4.57	high_impact	4.41	0.7	neutral	0.39	neutral	3.42	23.00	deleterious	0.08	0.35	0.54	disease	0.84	disease	0.69	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.03	medium_impact	2.66	high_impact	0.24	0.8	16.35	25.33	0.51	N	0.59	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3634	3634	A	C	MI.11441	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	328	110	S	R	Agc/Cgc	-5.07	0	0	probably_damaging	1	neutral	0.11	neutral	2.15	deleterious	-4.61	deleterious	-4.53	high_impact	4.76	0.7	neutral	0.37	neutral	3.80	23.40	deleterious	0.04	0.35	0.64	disease	0.9	disease	0.8	disease	0.78	disease	6	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	-0.23	medium_impact	2.97	high_impact	0.32	0.8	16.35	25.33	0.74	P	0.96	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3635	3635	G	C	MI.11442	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	329	110	S	T	aGc/aCc	5.5	1	0.01	probably_damaging	1	neutral	0.12	neutral	2.2	deleterious	-3.37	deleterious	-2.74	medium_impact	2.92	0.63	neutral	0.41	neutral	3.27	22.80	deleterious	0.24	0.45	0.38	neutral	0.67	disease	0.67	disease	0.65	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	-0.21	medium_impact	1.36	medium_impact	0.36	0.8	16.35	25.33	0.62	P	0.66	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3635	3635	G	A	MI.11443	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	329	110	S	N	aGc/aAc	5.5	1	0.01	probably_damaging	1	neutral	0.19	neutral	2.16	deleterious	-4.17	deleterious	-2.68	high_impact	4.41	0.66	neutral	0.45	neutral	3.52	23.10	deleterious	0.29	0.45	0.62	disease	0.81	disease	0.72	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	-0.08	medium_impact	2.66	high_impact	0.31	0.8	16.35	25.33	0.75	P	0.60	disease_causing_automatic	0	0.44	rs397515507	Pathogenic	Leber's_optic_atrophy	76426	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	G3635A	LHON	+	-	Cfrm	9	P	P	P	damaging
chrM	3635	3635	G	T	MI.11444	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	329	110	S	I	aGc/aTc	5.5	1	0.01	probably_damaging	1	neutral	0.36	neutral	2.14	deleterious	-5.15	deleterious	-5.49	high_impact	4.76	0.69	neutral	0.51	neutral	4.04	23.70	deleterious	0.05	0.35	0.51	disease	0.92	disease	0.73	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.14	medium_impact	2.97	high_impact	0.23	0.8	16.35	25.33	0.74	P	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3637	3637	C	A	MI.11445	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	331	111	L	M	Cta/Ata	-0.24	0	0	probably_damaging	1	neutral	0.18	neutral	2.15	deleterious	-3.61	neutral	-1.16	low_impact	0.96	0.73	neutral	0.58	neutral	2.51	19.54	deleterious	0.28	0.45	0.45	neutral	0.22	neutral	0.35	neutral	0.38	neutral	2	1	deleterious	0.09	neutral	-2	neutral	0.70	deleterious	-3.57	low_impact	-0.09	medium_impact	-0.35	medium_impact	0.54	0.8	60.06	9.93	0.43	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3637	3637	C	G	MI.11446	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	331	111	L	V	Cta/Gta	-0.24	0	0	probably_damaging	1	neutral	0.24	neutral	2.28	neutral	-2.1	neutral	-2.29	medium_impact	2.33	0.7	neutral	0.44	neutral	3.36	22.90	deleterious	0.27	0.45	0.25	neutral	0.57	disease	0.55	disease	0.54	disease	1	1	deleterious	0.12	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	-0.01	medium_impact	0.85	medium_impact	0.49	0.8	60.06	9.93	0.38	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3638	3638	T	C	MI.11447	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	332	111	L	P	cTa/cCa	-0.93	0	0	probably_damaging	1	deleterious	0.04	neutral	2.09	deleterious	-6.32	deleterious	-5.86	high_impact	3.86	0.67	neutral	0.33	neutral	3.86	23.50	deleterious	0.04	0.35	0.88	disease	0.86	disease	0.76	disease	0.78	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-3.57	low_impact	-0.5	medium_impact	2.18	high_impact	0.18	0.8	60.06	9.93	0.4	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3638	3638	T	G	MI.11448	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	332	111	L	R	cTa/cGa	-0.93	0	0	probably_damaging	1	neutral	0.08	neutral	2.09	deleterious	-5.78	deleterious	-4.98	high_impact	4.41	0.68	neutral	0.31	neutral	4.13	23.80	deleterious	0.04	0.35	0.85	disease	0.88	disease	0.76	disease	0.79	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.32	medium_impact	2.66	high_impact	0.10	0.8	60.06	9.93	0.52	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3638	3638	T	A	MI.11449	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	332	111	L	Q	cTa/cAa	-0.93	0	0	probably_damaging	1	neutral	0.06	neutral	2.09	deleterious	-5.75	deleterious	-4.87	high_impact	3.86	0.73	neutral	0.34	neutral	4.02	23.60	deleterious	0.06	0.35	0.85	disease	0.78	disease	0.64	disease	0.74	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.4	medium_impact	2.18	high_impact	0.20	0.8	60.06	9.93	0.4	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9065	9065	C	G	MI.1145	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	539	180	A	G	gCa/gGa	0.36	0	0	possibly_damaging	0.47	neutral	0.33	neutral	4.31	neutral	-1.81	deleterious	-2.78	low_impact	0.81	0.85	neutral	0.62	neutral	2.31	18.25	deleterious	0.32	0.65	0.75	disease	0.48	neutral	0.45	neutral	0.62	disease	2	0.64	neutral	0.43	neutral	-3	neutral	0.50	deleterious	-0.71	medium_impact	0.12	medium_impact	-0.4	medium_impact	0.82	0.9	19.91	14.58	0.33	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3640	3640	G	T	MI.11450	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	334	112	A	S	Gcc/Tcc	-1.85	0	0	benign	0.08	neutral	0.65	neutral	2.77	neutral	-0.5	neutral	-1.42	neutral_impact	0.27	0.82	neutral	0.89	neutral	0.48	7.25	deleterious	0.31	0.45	0.21	neutral	0.45	neutral	0.25	neutral	0.45	neutral	1	0.26	neutral	0.79	deleterious	-6	neutral	0.16	neutral	0.25	medium_impact	0.43	medium_impact	-0.95	medium_impact	0.41	0.8	29.87	28.44	0.3	N	0.05	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3640	3640	G	C	MI.11451	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	334	112	A	P	Gcc/Ccc	-1.85	0	0	possibly_damaging	0.86	neutral	0.16	neutral	2.61	neutral	-1.94	deleterious	-3.41	medium_impact	3.35	0.68	neutral	0.34	neutral	1.98	16.09	deleterious	0.06	0.35	0.53	disease	0.9	disease	0.62	disease	0.74	disease	5	0.93	neutral	0.15	neutral	0	NA	0.71	deleterious	-1.49	low_impact	-0.13	medium_impact	1.74	medium_impact	0.39	0.8	29.87	28.44	0.42	N	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3640	3640	G	A	MI.11452	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	334	112	A	T	Gcc/Acc	-1.85	0	0	benign	0.03	neutral	0.33	neutral	2.68	neutral	-1.66	neutral	-1.65	neutral_impact	0.26	0.81	neutral	0.79	neutral	0.84	9.73	deleterious	0.18	0.45	0.25	neutral	0.37	neutral	0.31	neutral	0.45	neutral	1	0.65	neutral	0.65	deleterious	-6	neutral	0.14	neutral	0.67	medium_impact	0.1	medium_impact	-0.96	medium_impact	0.59	0.8	29.87	28.44	0.4	N	0.04	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3641	3641	C	A	MI.11453	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	335	112	A	D	gCc/gAc	-0.01	0	0	possibly_damaging	0.73	neutral	0.16	neutral	2.64	neutral	-2.32	deleterious	-4.01	medium_impact	3	0.74	neutral	0.36	neutral	2.66	20.50	deleterious	0.04	0.35	0.37	neutral	0.89	disease	0.67	disease	0.75	disease	5	0.88	neutral	0.22	neutral	0	NA	0.60	deleterious	-1.16	low_impact	-0.13	medium_impact	1.43	medium_impact	0.26	0.8	29.87	28.44	0.4	N	0.61	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3641	3641	C	T	MI.11454	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	335	112	A	V	gCc/gTc	-0.01	0	0	benign	0.18	neutral	0.54	neutral	2.68	neutral	-1.82	neutral	-2.44	medium_impact	2.46	0.7	neutral	0.51	neutral	2.43	19.04	deleterious	0.17	0.45	0.32	neutral	0.72	disease	0.55	disease	0.66	disease	3	0.35	neutral	0.68	deleterious	-3	neutral	0.22	neutral	-0.13	medium_impact	0.31	medium_impact	0.96	medium_impact	0.57	0.8	29.87	28.44	0.3	N	0.42	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3641	3641	C	G	MI.11455	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	335	112	A	G	gCc/gGc	-0.01	0	0	possibly_damaging	0.52	neutral	0.38	neutral	2.68	neutral	-0.01	deleterious	-2.94	neutral_impact	0.61	0.85	neutral	0.63	neutral	1.95	15.88	deleterious	0.29	0.45	0.18	neutral	0.33	neutral	0.26	neutral	0.45	neutral	1	0.61	neutral	0.43	neutral	-3	neutral	0.26	neutral	-0.78	medium_impact	0.16	medium_impact	-0.66	medium_impact	0.65	0.8	29.87	28.44	0.3	N	0.32	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3643	3643	G	C	MI.11456	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	337	113	V	L	Gtt/Ctt	-4.38	0	0	possibly_damaging	0.73	neutral	1	neutral	2.32	neutral	-2.72	deleterious	-2.68	high_impact	3.81	0.72	neutral	0.59	neutral	3.58	23.20	deleterious	0.27	0.45	0.32	neutral	0.82	disease	0.59	disease	0.67	disease	3	0.73	neutral	0.64	deleterious	1	deleterious	0.65	deleterious	-1.16	low_impact	1.96	high_impact	2.14	high_impact	0.49	0.8	56.6	9.69	0.38	N	0.71	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3643	3643	G	A	MI.11457	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	337	113	V	I	Gtt/Att	-4.38	0	0	possibly_damaging	0.79	neutral	0.48	neutral	2.34	neutral	-2.55	neutral	-0.92	medium_impact	3	0.73	neutral	0.68	neutral	3.52	23.10	deleterious	0.33	0.5	0.31	neutral	0.69	disease	0.56	disease	0.57	disease	1	0.77	neutral	0.35	neutral	0	NA	0.66	deleterious	-1.29	low_impact	0.26	medium_impact	1.43	medium_impact	0.62	0.8	56.6	9.69	0.45	N	0.39	polymorphism	1	0.06	.	.	.	.	.	.	COSM1155619	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3643	3643	G	T	MI.11458	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	337	113	V	F	Gtt/Ttt	-4.38	0	0	probably_damaging	0.98	neutral	0.71	neutral	2.25	deleterious	-4.42	deleterious	-4.48	high_impact	4.44	0.68	neutral	0.55	neutral	3.81	23.40	deleterious	0.05	0.35	0.51	disease	0.93	disease	0.65	disease	0.75	disease	5	0.97	neutral	0.37	neutral	2	deleterious	0.82	deleterious	-2.34	low_impact	0.49	medium_impact	2.69	high_impact	0.34	0.8	56.6	9.69	0.44	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3644	3644	T	G	MI.11459	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	338	113	V	G	gTt/gGt	7.11	1	0.04	possibly_damaging	0.88	neutral	0.28	neutral	2.26	deleterious	-4.12	deleterious	-6.15	medium_impact	3.02	0.7	neutral	0.65	neutral	3.70	23.30	deleterious	0.04	0.35	0.54	disease	0.84	disease	0.64	disease	0.7	disease	4	0.91	neutral	0.2	neutral	0	NA	0.73	deleterious	-1.56	low_impact	0.05	medium_impact	1.45	medium_impact	0.20	0.8	56.6	9.69	0.6	P	0.95	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9065	9065	C	T	MI.1146	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	539	180	A	V	gCa/gTa	0.36	0	0	benign	0.39	neutral	0.91	neutral	4.48	neutral	0.88	neutral	-1	neutral_impact	-0.37	0.94	neutral	0.96	neutral	0.10	3.56	deleterious	0.48	0.65	0.41	neutral	0.18	neutral	0.29	neutral	0.25	neutral	5	0.3	neutral	0.76	deleterious	-6	neutral	0.41	neutral	-0.57	medium_impact	0.86	medium_impact	-1.42	low_impact	0.81	0.9	19.91	14.58	0.24	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	COSM6716154	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3644	3644	T	A	MI.11460	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	338	113	V	D	gTt/gAt	7.11	1	0.04	probably_damaging	0.98	neutral	0.13	neutral	2.25	deleterious	-4.67	deleterious	-6.23	high_impact	4.79	0.73	neutral	0.57	neutral	4.33	24.00	deleterious	0.03	0.35	0.56	disease	0.91	disease	0.76	disease	0.76	disease	5	0.99	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-2.34	low_impact	-0.19	medium_impact	3	high_impact	0.06	0.8	56.6	9.69	0.71	P	0.99	polymorphism	0.99	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3644	3644	T	C	MI.11461	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	338	113	V	A	gTt/gCt	7.11	1	0.04	benign	0.12	neutral	0.63	neutral	2.32	neutral	-2.79	deleterious	-3.33	medium_impact	3.21	0.65	neutral	0.72	neutral	3.33	22.90	deleterious	0.13	0.4	0.29	neutral	0.66	disease	0.56	disease	0.55	disease	1	0.27	neutral	0.76	deleterious	-3	neutral	0.23	neutral	0.06	medium_impact	0.4	medium_impact	1.62	medium_impact	0.09	0.8	56.6	9.69	0.63	P	0.64	polymorphism	1	0.19	rs878991470	.	.	.	.	.	.	CPD	0.45	T3644C	BD-associated	.	.	Reported	3	N	P	N,P	damaging
chrM	3646	3646	T	A	MI.11462	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	340	114	Y	N	Tac/Aac	-20	0	0	possibly_damaging	0.89	neutral	0.31	neutral	2.33	deleterious	-4.47	deleterious	-8.23	high_impact	4.5	0.72	neutral	0.12	damaging	3.92	23.50	deleterious	0.06	0.35	0.75	disease	0.8	disease	0.72	disease	0.67	disease	3	0.91	neutral	0.21	neutral	1	deleterious	0.75	deleterious	-1.6	low_impact	0.08	medium_impact	2.74	high_impact	0.20	0.8	51.89	8.86	0.46	N	0.95	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3646	3646	T	C	MI.11463	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	340	114	Y	H	Tac/Cac	-20	0	0	benign	0.12	neutral	0.53	neutral	2.33	deleterious	-4.38	deleterious	-4.57	medium_impact	3.4	0.75	neutral	0.25	damaging	3.42	23.00	deleterious	0.14	0.4	0.7	disease	0.73	disease	0.78	disease	0.67	disease	3	0.38	neutral	0.71	deleterious	-3	neutral	0.30	neutral	0.06	medium_impact	0.3	medium_impact	1.78	medium_impact	0.26	0.8	51.89	8.86	0.27	N	0.48	polymorphism	1	0.27	rs879122447	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3646	3646	T	G	MI.11464	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	340	114	Y	D	Tac/Gac	-20	0	0	probably_damaging	0.96	neutral	0.2	neutral	2.32	deleterious	-5	deleterious	-9.15	high_impact	4.85	0.76	neutral	0.09	damaging	3.85	23.40	deleterious	0.03	0.35	0.84	disease	0.85	disease	0.82	disease	0.77	disease	5	0.97	neutral	0.12	neutral	2	deleterious	0.81	deleterious	-2.05	low_impact	-0.06	medium_impact	3.05	high_impact	0.17	0.8	51.89	8.86	0.61	P	0.99	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3647	3647	A	C	MI.11465	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	341	114	Y	S	tAc/tCc	3.67	1	0	probably_damaging	0.92	neutral	0.43	neutral	2.35	deleterious	-3.7	deleterious	-8.2	high_impact	4.85	0.72	neutral	0.11	damaging	3.65	23.20	deleterious	0.06	0.35	0.63	disease	0.81	disease	0.74	disease	0.73	disease	5	0.92	neutral	0.26	neutral	2	deleterious	0.78	deleterious	-1.75	low_impact	0.21	medium_impact	3.05	high_impact	0.20	0.8	51.89	8.86	0.69	P	0.92	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3647	3647	A	T	MI.11466	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	341	114	Y	F	tAc/tTc	3.67	1	0	possibly_damaging	0.85	neutral	0.7	neutral	2.42	neutral	-2.38	deleterious	-3.66	medium_impact	2.75	0.66	neutral	0.1	damaging	3.34	22.90	deleterious	0.24	0.45	0.17	neutral	0.78	disease	0.68	disease	0.61	disease	2	0.82	neutral	0.43	neutral	0	NA	0.65	deleterious	-1.46	low_impact	0.48	medium_impact	1.21	medium_impact	0.46	0.8	51.89	8.86	0.49	N	0.72	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3647	3647	A	G	MI.11467	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	341	114	Y	C	tAc/tGc	3.67	1	0	probably_damaging	0.98	neutral	0.18	neutral	2.32	deleterious	-5.33	deleterious	-8.25	high_impact	4.85	0.74	neutral	0.07	damaging	3.50	23.10	deleterious	0.05	0.35	0.79	disease	0.83	disease	0.78	disease	0.76	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-2.34	low_impact	-0.09	medium_impact	3.05	high_impact	0.10	0.8	51.89	8.86	0.68	P	0.99	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3649	3649	T	G	MI.11468	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	343	115	S	A	Tca/Gca	-0.7	0.11	0	probably_damaging	1	neutral	0.51	neutral	2.78	neutral	-0.21	neutral	-2.14	low_impact	1.07	0.9	neutral	0.9	neutral	2.50	19.44	deleterious	0.28	0.45	0.18	neutral	0.35	neutral	0.36	neutral	0.43	neutral	1	1	deleterious	0.26	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.29	medium_impact	-0.25	medium_impact	0.57	0.8	56.29	9.66	0.38	N	0.46	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3649	3649	T	C	MI.11469	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	343	115	S	P	Tca/Cca	-0.7	0.11	0	probably_damaging	1	neutral	0.2	neutral	2.61	neutral	-2.92	deleterious	-4.03	medium_impact	2.13	0.72	neutral	0.15	damaging	3.97	23.60	deleterious	0.03	0.35	0.43	neutral	0.86	disease	0.52	disease	0.6	disease	2	1	deleterious	0.1	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	-0.06	medium_impact	0.67	medium_impact	0.40	0.8	56.29	9.66	0.35	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9065	9065	C	A	MI.1147	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	539	180	A	E	gCa/gAa	0.36	0	0	possibly_damaging	0.71	neutral	0.25	neutral	4.33	neutral	-1.18	deleterious	-2.77	low_impact	1.34	0.88	neutral	0.62	neutral	3.14	22.60	deleterious	0.21	0.65	0.64	disease	0.75	disease	0.61	disease	0.6	disease	2	0.81	neutral	0.27	neutral	-3	neutral	0.66	deleterious	-1.13	low_impact	0.02	medium_impact	0.05	medium_impact	0.77	0.9	19.91	14.58	0.31	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3649	3649	T	A	MI.11470	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	343	115	S	T	Tca/Aca	-0.7	0.11	0	probably_damaging	1	neutral	0.4	neutral	2.8	neutral	-0.03	neutral	-1.85	neutral_impact	0.21	0.87	neutral	0.89	neutral	2.72	20.90	deleterious	0.26	0.45	0.21	neutral	0.24	neutral	0.29	neutral	0.42	neutral	2	1	deleterious	0.2	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.18	medium_impact	-1.01	low_impact	0.68	0.85	56.29	9.66	0.42	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3650	3650	C	T	MI.11471	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	344	115	S	L	tCa/tTa	3.44	1	0	probably_damaging	1	neutral	0.67	neutral	2.62	neutral	-2.46	deleterious	-4.79	medium_impact	2.48	0.71	neutral	0.12	damaging	4.58	24.40	deleterious	0.08	0.35	0.3	neutral	0.84	disease	0.56	disease	0.68	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.45	medium_impact	0.98	medium_impact	0.54	0.8	56.29	9.66	0.4	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3650	3650	C	G	MI.11472	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	344	115	S	W	tCa/tGa	3.44	1	0	probably_damaging	1	neutral	0.18	neutral	2.58	deleterious	-5.73	deleterious	-5.77	medium_impact	3.25	0.72	neutral	0.11	damaging	4.29	24.00	deleterious	0.05	0.35	0.78	disease	0.88	disease	0.65	disease	0.71	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.82	deleterious	-3.57	low_impact	-0.09	medium_impact	1.65	medium_impact	0.23	0.8	56.29	9.66	0.47	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3652	3652	A	C	MI.11473	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	346	116	I	L	Atc/Ctc	-20	0	0	possibly_damaging	0.64	neutral	0.65	neutral	2.8	neutral	-0.01	neutral	-1.77	medium_impact	2.04	0.81	neutral	0.53	neutral	3.67	23.30	deleterious	0.28	0.45	0.18	neutral	0.44	neutral	0.34	neutral	0.4	neutral	2	0.58	neutral	0.51	deleterious	0	NA	0.38	neutral	-0.99	medium_impact	0.43	medium_impact	0.59	medium_impact	0.65	0.8	60.06	9.79	0.33	N	0.82	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3652	3652	A	G	MI.11474	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	346	116	I	V	Atc/Gtc	-20	0	0	possibly_damaging	0.64	neutral	0.5	neutral	2.85	neutral	0.19	neutral	-0.85	low_impact	1.9	0.75	neutral	0.58	neutral	2.89	21.80	deleterious	0.33	0.5	0.19	neutral	0.12	neutral	0.36	neutral	0.27	neutral	5	0.62	neutral	0.43	neutral	-3	neutral	0.29	neutral	-0.99	medium_impact	0.28	medium_impact	0.47	medium_impact	0.44	0.8	60.06	9.79	0.4	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3652	3652	A	T	MI.11475	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	346	116	I	F	Atc/Ttc	-20	0	0	probably_damaging	0.97	neutral	0.7	neutral	2.55	neutral	-2.46	deleterious	-3.58	medium_impact	2.6	0.72	neutral	0.36	neutral	3.81	23.40	deleterious	0.14	0.4	0.29	neutral	0.74	disease	0.54	disease	0.61	disease	2	0.96	neutral	0.37	neutral	1	deleterious	0.68	deleterious	-2.17	low_impact	0.48	medium_impact	1.08	medium_impact	0.62	0.8	60.06	9.79	0.29	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3653	3653	T	A	MI.11476	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	347	116	I	N	aTc/aAc	2.98	0.98	0	probably_damaging	0.94	neutral	0.3	neutral	2.51	deleterious	-4.14	deleterious	-6.21	high_impact	4.43	0.75	neutral	0.45	neutral	4.55	24.30	deleterious	0.06	0.35	0.44	neutral	0.78	disease	0.62	disease	0.67	disease	3	0.95	neutral	0.18	neutral	2	deleterious	0.69	deleterious	-1.87	low_impact	0.07	medium_impact	2.68	high_impact	0.33	0.8	60.06	9.79	0.62	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3653	3653	T	G	MI.11477	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	347	116	I	S	aTc/aGc	2.98	0.98	0	possibly_damaging	0.83	neutral	0.41	neutral	2.53	deleterious	-3.08	deleterious	-5.27	high_impact	3.63	0.74	neutral	0.53	neutral	4.22	23.90	deleterious	0.04	0.35	0.35	neutral	0.77	disease	0.6	disease	0.66	disease	3	0.83	neutral	0.29	neutral	1	deleterious	0.58	deleterious	-1.4	low_impact	0.19	medium_impact	1.98	medium_impact	0.31	0.8	60.06	9.79	0.57	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3653	3653	T	C	MI.11478	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	347	116	I	T	aTc/aCc	2.98	0.98	0	benign	0.12	neutral	0.39	neutral	2.59	neutral	-1.78	deleterious	-4.32	low_impact	1.66	0.78	neutral	0.56	neutral	3.37	22.90	deleterious	0.08	0.35	0.25	neutral	0.49	neutral	0.43	neutral	0.43	neutral	1	0.55	neutral	0.64	deleterious	-6	neutral	0.15	neutral	0.06	medium_impact	0.17	medium_impact	0.26	medium_impact	0.35	0.8	60.06	9.79	0.51	N	0.96	polymorphism	1	0.13	.	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3654	3654	C	A	MI.11479	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	348	116	I	M	atC/atA	7.34	1	0	probably_damaging	0.97	neutral	0.22	neutral	2.55	neutral	-2.62	deleterious	-2.65	medium_impact	2.96	0.73	neutral	0.47	neutral	3.85	23.40	deleterious	0.22	0.45	0.34	neutral	0.47	neutral	0.52	disease	0.47	neutral	1	0.98	neutral	0.13	neutral	1	deleterious	0.65	deleterious	-2.17	low_impact	-0.03	medium_impact	1.4	medium_impact	0.54	0.8	60.06	9.79	0.67	P	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9067	9067	A	T	MI.1148	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	541	181	M	L	Ata/Tta	-11.9	0	0	benign	0	neutral	1	neutral	4.08	neutral	1.11	neutral	1.22	neutral_impact	-1.58	0.79	neutral	0.95	neutral	-1.03	0.01	neutral	0.52	0.65	0.29	neutral	0.16	neutral	0.37	neutral	0.24	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.09	high_impact	1.98	high_impact	-2.45	low_impact	0.57	0.9	45.13	8.06	0.29	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3654	3654	C	G	MI.11480	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	348	116	I	M	atC/atG	7.34	1	0	probably_damaging	0.97	neutral	0.22	neutral	2.55	neutral	-2.62	deleterious	-2.65	medium_impact	2.96	0.73	neutral	0.47	neutral	3.39	23.00	deleterious	0.22	0.45	0.34	neutral	0.47	neutral	0.52	disease	0.47	neutral	1	0.98	neutral	0.13	neutral	1	deleterious	0.65	deleterious	-2.17	low_impact	-0.03	medium_impact	1.4	medium_impact	0.54	0.8	60.06	9.79	0.67	P	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3655	3655	C	G	MI.11481	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	349	117	L	V	Ctc/Gtc	-5.3	0	0	probably_damaging	1	neutral	0.63	neutral	2.17	neutral	-2.74	deleterious	-2.69	medium_impact	2.68	0.68	neutral	0.1	damaging	3.38	22.90	deleterious	0.29	0.45	0.29	neutral	0.5	neutral	0.55	disease	0.6	disease	2	1	deleterious	0.32	neutral	1	deleterious	0.69	deleterious	-3.57	low_impact	0.4	medium_impact	1.15	medium_impact	0.66	0.8	60.06	10.09	0.21	N	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3655	3655	C	A	MI.11482	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	349	117	L	I	Ctc/Atc	-5.3	0	0	probably_damaging	1	neutral	0.45	neutral	2.28	neutral	-1.91	neutral	-1.8	medium_impact	2.26	0.78	neutral	0.13	damaging	4.03	23.70	deleterious	0.29	0.45	0.26	neutral	0.54	disease	0.38	neutral	0.37	neutral	3	1	deleterious	0.23	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.23	medium_impact	0.79	medium_impact	0.55	0.8	60.06	10.09	0.24	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3655	3655	C	T	MI.11483	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	349	117	L	F	Ctc/Ttc	-5.3	0	0	probably_damaging	1	neutral	0.64	neutral	2.09	deleterious	-4	deleterious	-3.61	medium_impact	2.56	0.69	neutral	0.09	damaging	3.93	23.50	deleterious	0.19	0.45	0.4	neutral	0.69	disease	0.64	disease	0.6	disease	2	1	deleterious	0.32	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.42	medium_impact	1.05	medium_impact	0.61	0.8	60.06	10.09	0.19	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3656	3656	T	A	MI.11484	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	350	117	L	H	cTc/cAc	-0.01	0	0	probably_damaging	1	neutral	0.42	neutral	2.04	deleterious	-6.82	deleterious	-6.32	high_impact	4.55	0.73	neutral	0.08	damaging	4.07	23.70	deleterious	0.03	0.35	0.78	disease	0.74	disease	0.72	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.2	medium_impact	2.79	high_impact	0.36	0.8	60.06	10.09	0.41	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3656	3656	T	C	MI.11485	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	350	117	L	P	cTc/cCc	-0.01	0	0	probably_damaging	1	neutral	0.21	neutral	2.04	deleterious	-6.58	deleterious	-6.28	high_impact	4.55	0.78	neutral	0.08	damaging	3.83	23.40	deleterious	0.01	0.35	0.77	disease	0.8	disease	0.75	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.05	medium_impact	2.79	high_impact	0.41	0.8	60.06	10.09	0.43	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3656	3656	T	G	MI.11486	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	350	117	L	R	cTc/cGc	-0.01	0	0	probably_damaging	1	neutral	0.27	neutral	2.04	deleterious	-6.01	deleterious	-5.41	high_impact	4.55	0.76	neutral	0.08	damaging	4.15	23.80	deleterious	0.01	0.35	0.71	disease	0.79	disease	0.76	disease	0.73	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.03	medium_impact	2.79	high_impact	0.29	0.8	60.06	10.09	0.47	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3658	3658	T	C	MI.11487	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	352	118	W	R	Tga/Cga	-2.08	0	0	probably_damaging	1	neutral	0.18	neutral	2.8	neutral	0.41	deleterious	-6.41	medium_impact	3.34	0.67	neutral	0.07	damaging	3.49	23.10	deleterious	0.05	0.35	0.34	neutral	0.76	disease	0.68	disease	0.71	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	-0.09	medium_impact	1.73	medium_impact	0.28	0.8	59.75	10.45	0.32	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3658	3658	T	G	MI.11488	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	352	118	W	G	Tga/Gga	-2.08	0	0	probably_damaging	1	neutral	0.29	neutral	2.84	neutral	1.26	deleterious	-2.88	neutral_impact	0.33	0.83	neutral	0.35	neutral	1.11	11.28	neutral	0.08	0.35	0.25	neutral	0.21	neutral	0.59	disease	0.39	neutral	2	1	deleterious	0.15	neutral	-2	neutral	0.67	deleterious	-3.57	low_impact	0.06	medium_impact	-0.9	medium_impact	0.23	0.8	59.75	10.45	0.3	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3659	3659	G	T	MI.11489	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	353	118	W	L	tGa/tTa	4.81	1	0	probably_damaging	1	neutral	0.92	neutral	2.95	neutral	4.87	deleterious	-6.7	neutral_impact	0.67	0.74	neutral	0.08	damaging	4.20	23.90	deleterious	0.1	0.4	0.21	neutral	0.65	disease	0.5	neutral	0.38	neutral	2	1	deleterious	0.46	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.87	medium_impact	-0.6	medium_impact	0.12	0.8	59.75	10.45	0.38	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9067	9067	A	C	MI.1149	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	541	181	M	L	Ata/Cta	-11.9	0	0	benign	0	neutral	1	neutral	4.08	neutral	1.11	neutral	1.22	neutral_impact	-1.58	0.79	neutral	0.95	neutral	-1.18	0.01	neutral	0.52	0.65	0.29	neutral	0.16	neutral	0.37	neutral	0.24	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.09	high_impact	1.98	high_impact	-2.45	low_impact	0.57	0.9	45.13	8.06	0.29	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3659	3659	G	C	MI.11490	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	353	118	W	S	tGa/tCa	4.81	1	0	probably_damaging	1	neutral	0.69	neutral	2.83	neutral	1.38	deleterious	-5.49	medium_impact	2.44	0.76	neutral	0.12	damaging	2.78	21.30	deleterious	0.08	0.35	0.22	neutral	0.76	disease	0.6	disease	0.63	disease	3	1	deleterious	0.35	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.47	medium_impact	0.94	medium_impact	0.24	0.8	59.75	10.45	0.4	N	0.99	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3660	3660	A	C	MI.11491	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	354	118	W	C	tgA/tgC	8.95	1	0	probably_damaging	1	neutral	0.15	neutral	2.79	neutral	0.06	deleterious	-6.28	medium_impact	2.02	0.69	neutral	0.07	damaging	3.96	23.60	deleterious	0.09	0.35	0.39	neutral	0.84	disease	0.58	disease	0.71	disease	4	1	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	-0.15	medium_impact	0.58	medium_impact	0.26	0.8	59.75	10.45	0.46	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3660	3660	A	T	MI.11492	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	354	118	W	C	tgA/tgT	8.95	1	0	probably_damaging	1	neutral	0.15	neutral	2.79	neutral	0.06	deleterious	-6.28	medium_impact	2.02	0.69	neutral	0.07	damaging	4.05	23.70	deleterious	0.09	0.35	0.39	neutral	0.84	disease	0.58	disease	0.71	disease	4	1	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	-0.15	medium_impact	0.58	medium_impact	0.26	0.8	59.75	10.45	0.46	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3661	3661	T	C	MI.11493	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	355	119	S	P	Tca/Cca	-0.01	0.96	0	probably_damaging	1	neutral	0.16	neutral	2.42	deleterious	-3.9	deleterious	-4.47	high_impact	4.34	0.71	neutral	0.16	damaging	3.93	23.50	deleterious	0.04	0.35	0.58	disease	0.87	disease	0.79	disease	0.74	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.13	medium_impact	2.6	high_impact	0.37	0.8	59.75	10.41	0.58	P	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3661	3661	T	G	MI.11494	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	355	119	S	A	Tca/Gca	-0.01	0.96	0	probably_damaging	1	neutral	0.53	neutral	2.79	neutral	-0.06	deleterious	-2.56	low_impact	1.2	0.83	neutral	0.28	damaging	3.62	23.20	deleterious	0.27	0.45	0.14	neutral	0.26	neutral	0.43	neutral	0.38	neutral	2	1	deleterious	0.27	neutral	-2	neutral	0.67	deleterious	-3.57	low_impact	0.3	medium_impact	-0.14	medium_impact	0.56	0.8	59.75	10.41	0.3	N	0.46	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3661	3661	T	A	MI.11495	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	355	119	S	T	Tca/Aca	-0.01	0.96	0	probably_damaging	1	neutral	0.41	neutral	2.47	neutral	-2.41	deleterious	-2.67	medium_impact	2.87	0.69	neutral	0.15	damaging	3.76	23.30	deleterious	0.27	0.45	0.31	neutral	0.7	disease	0.61	disease	0.64	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.19	medium_impact	1.32	medium_impact	0.74	0.85	59.75	10.41	0.39	N	0.68	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3662	3662	C	G	MI.11496	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	356	119	S	W	tCa/tGa	7.34	1	0	probably_damaging	1	neutral	0.17	neutral	2.39	deleterious	-6.83	deleterious	-6.26	high_impact	4.34	0.75	neutral	0.15	damaging	4.28	24.00	deleterious	0.05	0.35	0.82	disease	0.9	disease	0.73	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	-0.11	medium_impact	2.6	high_impact	0.20	0.8	59.75	10.41	0.64	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3662	3662	C	T	MI.11497	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	356	119	S	L	tCa/tTa	7.34	1	0	probably_damaging	1	neutral	0.81	neutral	2.42	deleterious	-3.59	deleterious	-5.34	medium_impact	2.98	0.74	neutral	0.11	damaging	4.55	24.30	deleterious	0.07	0.35	0.36	neutral	0.88	disease	0.65	disease	0.7	disease	4	1	deleterious	0.41	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.63	medium_impact	1.41	medium_impact	0.52	0.8	59.75	10.41	0.49	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3664	3664	G	T	MI.11498	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	358	120	G	W	Ggg/Tgg	-2.54	0	0	probably_damaging	1	neutral	0.21	neutral	1.07	deleterious	-9.79	deleterious	-7.25	high_impact	4.95	0.46	damaging	0.04	damaging	4.39	24.10	deleterious	0.03	0.35	0.94	disease	0.92	disease	0.78	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.05	medium_impact	3.13	high_impact	0.10	0.8	59.43	10.6	0.51	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3664	3664	G	C	MI.11499	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	358	120	G	R	Ggg/Cgg	-2.54	0	0	probably_damaging	1	neutral	0.3	neutral	1.09	deleterious	-7.33	deleterious	-7.22	high_impact	4.95	0.57	damaging	0.07	damaging	3.97	23.60	deleterious	0.02	0.35	0.74	disease	0.89	disease	0.82	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.07	medium_impact	3.13	high_impact	0.48	0.8	59.43	10.6	0.62	P	0.99	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8579	8579	C	T	MI.115	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	53	18	P	L	cCc/cTc	1.29	0.83	0	probably_damaging	1	deleterious	0.01	neutral	4.65	neutral	1.06	deleterious	-8.49	medium_impact	2.75	0.7	neutral	0.47	neutral	4.08	23.70	deleterious	0.46	0.65	0.24	neutral	0.89	disease	0.64	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-3.6	low_impact	-0.84	medium_impact	1.26	medium_impact	0.77	0.9	21.24	15.57	0.37	N	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9067	9067	A	G	MI.1150	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	541	181	M	V	Ata/Gta	-11.9	0	0	benign	0.01	deleterious	0	neutral	3.92	neutral	-0.14	neutral	-0.97	low_impact	0.9	0.88	neutral	0.7	neutral	1.00	10.64	neutral	0.61	0.7	0.47	neutral	0.46	neutral	0.5	neutral	0.49	neutral	0	1	deleterious	0.5	deleterious	-2	neutral	0.17	neutral	1.14	medium_impact	-1.4	low_impact	-0.33	medium_impact	0.65	0.9	45.13	8.06	0.4	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3665	3665	G	C	MI.11500	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	359	120	G	A	gGg/gCg	8.95	1	0	probably_damaging	1	neutral	0.47	neutral	1.13	deleterious	-5.7	deleterious	-5.43	high_impact	3.7	0.31	damaging	0.07	damaging	3.08	22.50	deleterious	0.04	0.35	0.41	neutral	0.78	disease	0.66	disease	0.67	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.25	medium_impact	2.04	high_impact	0.42	0.8	59.43	10.6	0.7	P	0.76	polymorphism	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3665	3665	G	T	MI.11501	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	359	120	G	V	gGg/gTg	8.95	1	0	probably_damaging	1	neutral	0.56	neutral	1.09	deleterious	-7.12	deleterious	-8.16	high_impact	4.95	0.39	damaging	0.05	damaging	3.73	23.30	deleterious	0.02	0.35	0.64	disease	0.89	disease	0.73	disease	0.73	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.33	medium_impact	3.13	high_impact	0.18	0.8	59.43	10.6	0.7	P	1.00	polymorphism	0.99	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3665	3665	G	A	MI.11502	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	359	120	G	E	gGg/gAg	8.95	1	0	probably_damaging	1	neutral	0.24	neutral	1.1	deleterious	-6.73	deleterious	-7.2	high_impact	4.95	0.46	damaging	0.04	damaging	3.90	23.50	deleterious	0.02	0.35	0.68	disease	0.9	disease	0.81	disease	0.75	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.01	medium_impact	3.13	high_impact	0.21	0.8	59.43	10.6	0.72	P	1.00	polymorphism	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3667	3667	T	G	MI.11503	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	361	121	W	G	Tga/Gga	-5.98	0	0.01	probably_damaging	1	neutral	0.33	neutral	2.52	deleterious	-4.17	deleterious	-11.75	high_impact	3.94	0.68	neutral	0.37	neutral	3.90	23.50	deleterious	0.05	0.35	0.65	disease	0.88	disease	0.83	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.1	medium_impact	2.25	high_impact	0.06	0.8	59.12	10.6	0.48	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3667	3667	T	C	MI.11504	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	361	121	W	R	Tga/Cga	-5.98	0	0.01	probably_damaging	1	neutral	0.35	neutral	2.52	deleterious	-4.28	deleterious	-12.68	high_impact	3.94	0.64	neutral	0.21	damaging	3.59	23.20	deleterious	0.03	0.35	0.64	disease	0.92	disease	0.88	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.12	medium_impact	2.25	high_impact	0.06	0.8	59.12	10.6	0.46	N	0.98	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3668	3668	G	C	MI.11505	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	362	121	W	S	tGa/tCa	7.34	1	0	probably_damaging	1	neutral	0.41	neutral	2.54	neutral	-2.8	deleterious	-12.67	high_impact	4.57	0.64	neutral	0.36	neutral	4.01	23.60	deleterious	0.05	0.35	0.51	disease	0.93	disease	0.83	disease	0.83	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.19	medium_impact	2.8	high_impact	0.06	0.8	59.12	10.6	0.68	P	0.99	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3668	3668	G	T	MI.11506	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	362	121	W	L	tGa/tTa	7.34	1	0	probably_damaging	1	neutral	0.65	neutral	2.63	neutral	-1.08	deleterious	-11.78	high_impact	3.71	0.65	neutral	0.32	neutral	4.27	23.90	deleterious	0.07	0.35	0.19	neutral	0.9	disease	0.83	disease	0.72	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.43	medium_impact	2.05	high_impact	0.06	0.8	59.12	10.6	0.61	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3669	3669	A	C	MI.11507	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	363	121	W	C	tgA/tgC	8.95	1	0	probably_damaging	1	neutral	0.18	neutral	2.51	deleterious	-4.71	deleterious	-11.78	high_impact	4.92	0.64	neutral	0.2	damaging	3.99	23.60	deleterious	0.04	0.35	0.7	disease	0.92	disease	0.86	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.09	medium_impact	3.11	high_impact	0.09	0.8	59.12	10.6	0.67	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3669	3669	A	T	MI.11508	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	363	121	W	C	tgA/tgT	8.95	1	0	probably_damaging	1	neutral	0.18	neutral	2.51	deleterious	-4.71	deleterious	-11.78	high_impact	4.92	0.64	neutral	0.2	damaging	4.10	23.70	deleterious	0.04	0.35	0.7	disease	0.92	disease	0.86	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.09	medium_impact	3.11	high_impact	0.09	0.8	59.12	10.6	0.67	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3670	3670	G	A	MI.11509	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	364	122	A	T	Gca/Aca	0.68	0.99	0	probably_damaging	1	neutral	0.39	neutral	2.5	neutral	-2.79	deleterious	-3.4	medium_impact	3.17	0.69	neutral	0.07	damaging	4.15	23.80	deleterious	0.16	0.45	0.31	neutral	0.83	disease	0.63	disease	0.68	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.17	medium_impact	1.58	medium_impact	0.71	0.85	58.49	10	0.44	N	0.70	polymorphism	1	0.15	.	.	.	.	.	pancreatic cancer cell line xenograft / endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9068	9068	T	C	MI.1151	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	542	181	M	T	aTa/aCa	-0.8	0	0	benign	0.03	deleterious	0	neutral	3.89	neutral	-1.09	deleterious	-2.71	low_impact	1.29	0.83	neutral	0.73	neutral	1.22	11.85	neutral	0.38	0.65	0.67	disease	0.46	neutral	0.51	disease	0.64	disease	3	1	deleterious	0.49	deleterious	-2	neutral	0.23	neutral	0.68	medium_impact	-1.4	low_impact	0.01	medium_impact	0.45	0.9	45.13	8.06	0.39	N	0.17	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3670	3670	G	C	MI.11510	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	364	122	A	P	Gca/Cca	0.68	0.99	0	probably_damaging	1	neutral	0.2	neutral	2.44	deleterious	-4.25	deleterious	-4.37	high_impact	4.37	0.72	neutral	0.06	damaging	3.81	23.40	deleterious	0.03	0.35	0.51	disease	0.92	disease	0.63	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	-0.06	medium_impact	2.63	high_impact	0.46	0.8	58.49	10	0.53	N	0.96	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3670	3670	G	T	MI.11511	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	364	122	A	S	Gca/Tca	0.68	0.99	0	probably_damaging	1	neutral	0.41	neutral	2.7	neutral	-0.54	neutral	-2.38	low_impact	0.88	0.82	neutral	0.28	damaging	3.61	23.20	deleterious	0.23	0.45	0.16	neutral	0.34	neutral	0.22	neutral	0.41	neutral	2	1	deleterious	0.21	neutral	-2	neutral	0.71	deleterious	-3.57	low_impact	0.19	medium_impact	-0.42	medium_impact	0.34	0.8	58.49	10	0.39	N	0.93	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3671	3671	C	T	MI.11512	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	365	122	A	V	gCa/gTa	5.73	1	0	probably_damaging	1	neutral	0.5	neutral	2.53	deleterious	-3.44	deleterious	-3.58	medium_impact	2.83	0.7	neutral	0.06	damaging	4.38	24.10	deleterious	0.1	0.4	0.34	neutral	0.84	disease	0.63	disease	0.69	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.28	medium_impact	1.28	medium_impact	0.72	0.85	58.49	10	0.52	N	0.72	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3671	3671	C	A	MI.11513	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	365	122	A	E	gCa/gAa	5.73	1	0	probably_damaging	1	neutral	0.27	neutral	2.46	neutral	-2	deleterious	-4.28	high_impact	4.37	0.76	neutral	0.08	damaging	4.55	24.30	deleterious	0.03	0.35	0.2	neutral	0.91	disease	0.74	disease	0.7	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.03	medium_impact	2.63	high_impact	0.23	0.8	58.49	10	0.65	P	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3671	3671	C	G	MI.11514	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	365	122	A	G	gCa/gGa	5.73	1	0	probably_damaging	1	neutral	0.34	neutral	2.49	neutral	-2.27	deleterious	-3.46	medium_impact	2.44	0.75	neutral	0.11	damaging	3.87	23.50	deleterious	0.21	0.45	0.26	neutral	0.75	disease	0.48	neutral	0.5	neutral	0	1	deleterious	0.17	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.11	medium_impact	0.94	medium_impact	0.62	0.8	58.49	10	0.53	N	0.79	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3673	3673	T	A	MI.11515	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	367	123	S	T	Tca/Aca	-7.13	0	0	probably_damaging	1	neutral	0.39	neutral	2.03	deleterious	-3.79	deleterious	-2.72	medium_impact	3.39	0.64	neutral	0.37	neutral	3.79	23.40	deleterious	0.14	0.4	0.36	neutral	0.72	disease	0.69	disease	0.67	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.17	medium_impact	1.77	medium_impact	0.51	0.8	59.12	10.43	0.42	N	0.68	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3673	3673	T	C	MI.11516	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	367	123	S	P	Tca/Cca	-7.13	0	0	probably_damaging	1	neutral	0.2	neutral	1.98	deleterious	-5.22	deleterious	-4.54	high_impact	4.57	0.73	neutral	0.49	neutral	3.97	23.60	deleterious	0.04	0.35	0.72	disease	0.84	disease	0.69	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.06	medium_impact	2.8	high_impact	0.19	0.8	59.12	10.43	0.53	N	0.99	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3673	3673	T	G	MI.11517	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	367	123	S	A	Tca/Gca	-7.13	0	0	probably_damaging	1	neutral	0.51	neutral	2.11	neutral	-2.76	deleterious	-2.71	medium_impact	3.18	0.7	neutral	0.48	neutral	3.67	23.30	deleterious	0.15	0.4	0.34	neutral	0.65	disease	0.62	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.29	medium_impact	1.59	medium_impact	0.40	0.8	59.12	10.43	0.38	N	0.46	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3674	3674	C	G	MI.11518	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	368	123	S	W	tCa/tGa	5.5	1	0	probably_damaging	1	neutral	0.19	neutral	1.95	deleterious	-8.14	deleterious	-6.35	high_impact	4.92	0.72	neutral	0.42	neutral	4.27	24.00	deleterious	0.04	0.35	0.92	disease	0.89	disease	0.75	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.08	medium_impact	3.11	high_impact	0.13	0.8	59.12	10.43	0.72	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3674	3674	C	T	MI.11519	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	368	123	S	L	tCa/tTa	5.5	1	0	probably_damaging	1	neutral	0.66	neutral	1.99	deleterious	-4.92	deleterious	-5.44	high_impact	4.92	0.65	neutral	0.42	neutral	4.56	24.40	deleterious	0.03	0.35	0.61	disease	0.89	disease	0.69	disease	0.7	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.44	medium_impact	3.11	high_impact	0.37	0.8	59.12	10.43	0.78	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9068	9068	T	A	MI.1152	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	542	181	M	K	aTa/aAa	-0.8	0	0	benign	0.04	deleterious	0	neutral	3.87	neutral	-2.16	deleterious	-3.58	low_impact	1.78	0.83	neutral	0.49	neutral	2.33	18.39	deleterious	0.16	0.65	0.82	disease	0.71	disease	0.74	disease	0.8	disease	6	1	deleterious	0.48	deleterious	-2	neutral	0.33	neutral	0.55	medium_impact	-1.4	low_impact	0.43	medium_impact	0.63	0.9	45.13	8.06	0.31	N	0.30	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3676	3676	A	C	MI.11520	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	370	124	N	H	Aac/Cac	-2.08	0	0	probably_damaging	1	neutral	0.54	neutral	2.3	deleterious	-4.38	deleterious	-4.48	high_impact	4.19	0.58	damaging	0.26	damaging	3.08	22.50	deleterious	0.22	0.45	0.64	disease	0.79	disease	0.78	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.31	medium_impact	2.47	high_impact	0.13	0.8	59.43	10.55	0.41	N	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3676	3676	A	G	MI.11521	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	370	124	N	D	Aac/Gac	-2.08	0	0	probably_damaging	1	neutral	0.2	neutral	2.37	neutral	-2.63	deleterious	-4.5	high_impact	3.91	0.75	neutral	0.45	neutral	3.84	23.40	deleterious	0.37	0.5	0.4	neutral	0.78	disease	0.75	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.06	medium_impact	2.23	high_impact	0.31	0.8	59.43	10.55	0.49	N	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3676	3676	A	T	MI.11522	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	370	124	N	Y	Aac/Tac	-2.08	0	0	probably_damaging	1	neutral	1	neutral	2.29	deleterious	-5.13	deleterious	-7.14	medium_impact	3.44	0.66	neutral	0.28	damaging	3.74	23.30	deleterious	0.07	0.35	0.77	disease	0.88	disease	0.78	disease	0.74	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.85	deleterious	-3.57	low_impact	1.96	high_impact	1.82	medium_impact	0.14	0.8	59.43	10.55	0.34	N	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3677	3677	A	T	MI.11523	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	371	124	N	I	aAc/aTc	8.49	1	0	probably_damaging	1	neutral	0.41	neutral	2.3	deleterious	-4.72	deleterious	-8.09	high_impact	4.88	0.77	neutral	0.51	neutral	3.74	23.30	deleterious	0.08	0.35	0.72	disease	0.92	disease	0.74	disease	0.75	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.19	medium_impact	3.07	high_impact	0.15	0.8	59.43	10.55	0.74	P	1.00	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3677	3677	A	C	MI.11524	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	371	124	N	T	aAc/aCc	8.49	1	0	probably_damaging	1	neutral	0.39	neutral	2.33	deleterious	-3.46	deleterious	-5.38	high_impact	4.34	0.61	neutral	0.36	neutral	3.26	22.80	deleterious	0.19	0.45	0.5	disease	0.81	disease	0.67	disease	0.68	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.17	medium_impact	2.6	high_impact	0.32	0.8	59.43	10.55	0.66	P	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3677	3677	A	G	MI.11525	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	371	124	N	S	aAc/aGc	8.49	1	0	probably_damaging	1	neutral	0.47	neutral	2.35	deleterious	-3	deleterious	-4.46	high_impact	3.56	0.66	neutral	0.64	neutral	2.94	22.00	deleterious	0.3	0.45	0.43	neutral	0.79	disease	0.67	disease	0.67	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.25	medium_impact	1.92	medium_impact	0.28	0.8	59.43	10.55	0.62	P	0.90	polymorphism	0.99	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3678	3678	C	A	MI.11526	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	372	124	N	K	aaC/aaA	8.49	1	0	probably_damaging	1	neutral	0.29	neutral	2.44	neutral	-1.85	deleterious	-5.4	medium_impact	3.5	0.64	neutral	0.28	neutral	4.40	24.10	deleterious	0.24	0.45	0.32	neutral	0.82	disease	0.77	disease	0.72	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	0.06	medium_impact	1.87	medium_impact	0.28	0.8	59.43	10.55	0.66	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3678	3678	C	G	MI.11527	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	372	124	N	K	aaC/aaG	8.49	1	0	probably_damaging	1	neutral	0.29	neutral	2.44	neutral	-1.85	deleterious	-5.4	medium_impact	3.5	0.64	neutral	0.28	neutral	4.00	23.60	deleterious	0.24	0.45	0.32	neutral	0.82	disease	0.77	disease	0.72	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	0.06	medium_impact	1.87	medium_impact	0.28	0.8	59.43	10.55	0.66	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3679	3679	T	C	MI.11528	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	373	125	S	P	Tca/Cca	-0.93	0.05	0.01	probably_damaging	1	neutral	0.2	neutral	2.33	deleterious	-5.25	deleterious	-4.53	high_impact	4.15	0.76	neutral	0.12	damaging	4.04	23.70	deleterious	0.03	0.35	0.74	disease	0.87	disease	0.6	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.06	medium_impact	2.44	high_impact	0.24	0.8	58.49	10.75	0.36	N	0.99	polymorphism	1	0.41	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3679	3679	T	A	MI.11529	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	373	125	S	T	Tca/Aca	-0.93	0.05	0.01	probably_damaging	1	neutral	0.38	neutral	2.37	deleterious	-3.87	deleterious	-2.73	high_impact	3.52	0.77	neutral	0.14	damaging	3.93	23.50	deleterious	0.12	0.4	0.41	neutral	0.74	disease	0.7	disease	0.7	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.16	medium_impact	1.89	medium_impact	0.58	0.8	58.49	10.75	0.32	N	0.68	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9069	9069	A	T	MI.1153	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	543	181	M	I	atA/atT	5.68	0.9	0	benign	0.01	neutral	0.14	neutral	3.94	neutral	-0.1	neutral	-0.24	neutral_impact	0	0.83	neutral	0.73	neutral	1.63	14.00	neutral	0.54	0.65	0.49	neutral	0.5	neutral	0.48	neutral	0.49	neutral	0	0.86	neutral	0.57	deleterious	-6	neutral	0.19	neutral	1.14	medium_impact	-0.15	medium_impact	-1.1	low_impact	0.69	0.9	45.13	8.06	0.45	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3679	3679	T	G	MI.11530	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	373	125	S	A	Tca/Gca	-0.93	0.05	0.01	probably_damaging	1	neutral	0.56	neutral	2.41	deleterious	-3.53	deleterious	-2.73	high_impact	4.84	0.71	neutral	0.12	damaging	3.70	23.30	deleterious	0.11	0.4	0.46	neutral	0.7	disease	0.71	disease	0.69	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.33	medium_impact	3.04	high_impact	0.37	0.8	58.49	10.75	0.61	P	0.46	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3680	3680	C	G	MI.11531	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	374	125	S	W	tCa/tGa	4.58	1	0	probably_damaging	1	neutral	0.29	neutral	2.3	deleterious	-8.39	deleterious	-6.37	high_impact	4.84	0.72	neutral	0.09	damaging	4.34	24.00	deleterious	0.04	0.35	0.95	disease	0.91	disease	0.76	disease	0.68	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.06	medium_impact	3.04	high_impact	0.15	0.8	58.49	10.75	0.7	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3680	3680	C	T	MI.11532	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	374	125	S	L	tCa/tTa	4.58	1	0	probably_damaging	1	neutral	0.67	neutral	2.34	deleterious	-5.21	deleterious	-5.46	high_impact	4.29	0.78	neutral	0.09	damaging	4.63	24.50	deleterious	0.03	0.35	0.72	disease	0.9	disease	0.7	disease	0.71	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.45	medium_impact	2.56	high_impact	0.36	0.8	58.49	10.75	0.55	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3682	3682	A	G	MI.11533	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	376	126	N	D	Aac/Gac	-1.62	0	0	possibly_damaging	0.72	neutral	0.2	neutral	2.74	neutral	-1	neutral	-1.03	medium_impact	2.94	0.66	neutral	0.25	damaging	3.84	23.40	deleterious	0.64	0.7	0.22	neutral	0.61	disease	0.62	disease	0.7	disease	4	0.85	neutral	0.24	neutral	0	NA	0.57	deleterious	-1.14	low_impact	-0.06	medium_impact	1.38	medium_impact	0.29	0.8	22.33	38.03	0.42	N	0.68	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3682	3682	A	T	MI.11534	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	376	126	N	Y	Aac/Tac	-1.62	0	0	probably_damaging	0.96	neutral	1	neutral	2.68	deleterious	-3.02	neutral	-1.98	medium_impact	2.04	0.68	neutral	0.3	neutral	3.75	23.30	deleterious	0.08	0.35	0.44	neutral	0.7	disease	0.62	disease	0.7	disease	4	0.96	neutral	0.52	deleterious	1	deleterious	0.75	deleterious	-2.05	low_impact	1.96	high_impact	0.59	medium_impact	0.17	0.8	22.33	38.03	0.23	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3682	3682	A	C	MI.11535	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	376	126	N	H	Aac/Cac	-1.62	0	0	probably_damaging	0.95	neutral	0.52	neutral	2.7	neutral	-2.13	neutral	-1.04	medium_impact	2.59	0.64	neutral	0.28	neutral	3.08	22.50	deleterious	0.4	0.5	0.34	neutral	0.47	neutral	0.63	disease	0.53	disease	1	0.94	neutral	0.29	neutral	1	deleterious	0.68	deleterious	-1.95	low_impact	0.29	medium_impact	1.07	medium_impact	0.14	0.8	22.33	38.03	0.34	N	0.38	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3683	3683	A	T	MI.11536	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	377	126	N	I	aAc/aTc	8.49	1	0	probably_damaging	0.95	neutral	0.4	neutral	2.69	neutral	-2.63	deleterious	-2.91	low_impact	1.47	0.67	neutral	0.28	neutral	3.75	23.30	deleterious	0.12	0.4	0.37	neutral	0.78	disease	0.58	disease	0.72	disease	4	0.95	neutral	0.23	neutral	-2	neutral	0.75	deleterious	-1.95	low_impact	0.18	medium_impact	0.1	medium_impact	0.14	0.8	22.33	38.03	0.5	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3683	3683	A	G	MI.11537	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	377	126	N	S	aAc/aGc	8.49	1	0	possibly_damaging	0.53	neutral	0.64	neutral	2.74	neutral	-0.97	neutral	-0.15	low_impact	1.24	0.78	neutral	0.28	neutral	2.94	22.00	deleterious	0.55	0.6	0.14	neutral	0.48	neutral	0.49	neutral	0.43	neutral	1	0.45	neutral	0.56	deleterious	-3	neutral	0.44	deleterious	-0.8	medium_impact	0.42	medium_impact	-0.11	medium_impact	0.15	0.8	22.33	38.03	0.53	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3683	3683	A	C	MI.11538	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	377	126	N	T	aAc/aCc	8.49	1	0	possibly_damaging	0.72	neutral	0.38	neutral	2.72	neutral	-1.35	neutral	-1.05	medium_impact	2.24	0.63	neutral	0.3	neutral	3.26	22.80	deleterious	0.38	0.5	0.18	neutral	0.49	neutral	0.57	disease	0.56	disease	1	0.74	neutral	0.33	neutral	0	NA	0.54	deleterious	-1.14	low_impact	0.16	medium_impact	0.77	medium_impact	0.20	0.8	22.33	38.03	0.67	P	0.43	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3684	3684	C	G	MI.11539	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	378	126	N	K	aaC/aaG	6.65	1	0	benign	0.03	neutral	0.37	neutral	3.23	neutral	2.2	neutral	4.14	neutral_impact	-1.8	0.7	neutral	0.81	neutral	1.27	12.09	neutral	0.49	0.55	0.23	neutral	0.05	neutral	0.26	neutral	0.18	neutral	6	0.61	neutral	0.67	deleterious	-6	neutral	0.12	neutral	0.67	medium_impact	0.15	medium_impact	-2.76	low_impact	0.41	0.8	22.33	38.03	0.62	P	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9069	9069	A	C	MI.1154	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	543	181	M	I	atA/atC	5.68	0.9	0	benign	0.01	neutral	0.14	neutral	3.94	neutral	-0.1	neutral	-0.24	neutral_impact	0	0.83	neutral	0.73	neutral	1.55	13.59	neutral	0.54	0.65	0.49	neutral	0.5	neutral	0.48	neutral	0.49	neutral	0	0.86	neutral	0.57	deleterious	-6	neutral	0.19	neutral	1.14	medium_impact	-0.15	medium_impact	-1.1	low_impact	0.69	0.9	45.13	8.06	0.45	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3684	3684	C	A	MI.11540	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	378	126	N	K	aaC/aaA	6.65	1	0	benign	0.03	neutral	0.37	neutral	3.23	neutral	2.2	neutral	4.14	neutral_impact	-1.8	0.7	neutral	0.81	neutral	1.69	14.36	neutral	0.49	0.55	0.23	neutral	0.05	neutral	0.26	neutral	0.18	neutral	6	0.61	neutral	0.67	deleterious	-6	neutral	0.12	neutral	0.67	medium_impact	0.15	medium_impact	-2.76	low_impact	0.41	0.8	22.33	38.03	0.63	P	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3685	3685	T	C	MI.11541	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	379	127	Y	H	Tac/Cac	1.14	1	0	probably_damaging	1	neutral	0.46	neutral	1.59	deleterious	-5.99	deleterious	-4.51	high_impact	4.57	0.61	neutral	0.03	damaging	3.66	23.20	deleterious	0.03	0.35	0.73	disease	0.81	disease	0.82	disease	0.74	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.24	medium_impact	2.8	high_impact	0.18	0.8	58.81	10.48	0.6	P	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3685	3685	T	A	MI.11542	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	379	127	Y	N	Tac/Aac	1.14	1	0	probably_damaging	1	neutral	0.44	neutral	1.58	deleterious	-7.03	deleterious	-8.11	high_impact	4.92	0.6	damaging	0.04	damaging	4.24	23.90	deleterious	0.02	0.35	0.86	disease	0.88	disease	0.75	disease	0.73	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.22	medium_impact	3.11	high_impact	0.11	0.8	58.81	10.48	0.63	P	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3685	3685	T	G	MI.11543	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	379	127	Y	D	Tac/Gac	1.14	1	0	probably_damaging	1	neutral	0.19	neutral	1.58	deleterious	-8.21	deleterious	-9.01	high_impact	4.92	0.64	neutral	0.03	damaging	4.00	23.60	deleterious	0.01	0.35	0.93	disease	0.89	disease	0.82	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.08	medium_impact	3.11	high_impact	0.13	0.8	58.81	10.48	0.61	P	1.00	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3686	3686	A	G	MI.11544	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	380	127	Y	C	tAc/tGc	7.34	1	0	probably_damaging	1	neutral	0.17	neutral	1.57	deleterious	-9.12	deleterious	-8.1	high_impact	4.92	0.59	damaging	0.03	damaging	3.55	23.10	deleterious	0.02	0.35	0.94	disease	0.89	disease	0.72	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.11	medium_impact	3.11	high_impact	0.13	0.8	58.81	10.48	0.62	P	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3686	3686	A	C	MI.11545	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	380	127	Y	S	tAc/tCc	7.34	1	0	probably_damaging	1	neutral	1	neutral	1.59	deleterious	-7.63	deleterious	-8.09	high_impact	4.92	0.54	damaging	0.06	damaging	3.70	23.30	deleterious	0.02	0.35	0.85	disease	0.88	disease	0.74	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.87	deleterious	-3.57	low_impact	1.96	high_impact	3.11	high_impact	0.12	0.8	58.81	10.48	0.64	P	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3686	3686	A	T	MI.11546	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	380	127	Y	F	tAc/tTc	7.34	1	0	probably_damaging	1	neutral	0.58	neutral	1.7	neutral	-2.03	deleterious	-3.58	medium_impact	2.94	0.62	neutral	0.03	damaging	3.41	23.00	deleterious	0.11	0.4	0.19	neutral	0.85	disease	0.64	disease	0.69	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.35	medium_impact	1.38	medium_impact	0.31	0.8	58.81	10.48	0.49	N	0.80	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3688	3688	G	C	MI.11547	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	382	128	A	P	Gcc/Ccc	-4.61	0	0	probably_damaging	1	neutral	0.17	neutral	2.5	neutral	-2.14	deleterious	-3.73	medium_impact	2.21	0.74	neutral	0.54	neutral	3.77	23.40	deleterious	0.02	0.35	0.46	neutral	0.86	disease	0.48	neutral	0.19	neutral	6	1	deleterious	0.09	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	-0.11	medium_impact	0.74	medium_impact	0.47	0.8	14.15	31.17	0.39	N	0.99	polymorphism	1	0.13	rs879107244	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3688	3688	G	A	MI.11548	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	382	128	A	T	Gcc/Acc	-4.61	0	0	probably_damaging	1	neutral	0.33	neutral	2.51	neutral	-1.97	deleterious	-3.25	medium_impact	3.4	0.67	neutral	0.45	neutral	4.32	24.00	deleterious	0.03	0.35	0.39	neutral	0.84	disease	0.59	disease	0.68	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.1	medium_impact	1.78	medium_impact	0.68	0.85	14.15	31.17	0.43	N	0.55	polymorphism	1	0.13	.	.	.	.	.	.	COSM6188312	.	.	G3688A	Leigh Syndrome	+	-	Reported	2	.	P	P	damaging
chrM	3688	3688	G	T	MI.11549	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	382	128	A	S	Gcc/Tcc	-4.61	0	0	probably_damaging	1	neutral	1	neutral	2.74	neutral	-0.29	neutral	-2.3	low_impact	1.65	0.8	neutral	0.75	neutral	2.57	19.89	deleterious	0.12	0.4	0.23	neutral	0.7	disease	0.22	neutral	0.2	neutral	6	1	deleterious	0.5	deleterious	-2	neutral	0.75	deleterious	-3.57	low_impact	1.96	high_impact	0.25	medium_impact	0.44	0.8	14.15	31.17	0.24	N	0.15	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9070	9070	T	C	MI.1155	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	544	182	S	P	Tca/Cca	-8.43	0	0	possibly_damaging	0.75	neutral	0.15	neutral	4.51	neutral	-2	neutral	-1.35	low_impact	1.45	0.83	neutral	0.64	neutral	3.94	23.50	deleterious	0.21	0.65	0.35	neutral	0.7	disease	0.61	disease	0.56	disease	1	0.89	neutral	0.2	neutral	-3	neutral	0.66	deleterious	-1.21	low_impact	-0.13	medium_impact	0.15	medium_impact	0.62	0.9	23.45	17.69	0.33	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3689	3689	C	T	MI.11550	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	383	128	A	V	gCc/gTc	7.11	1	0	probably_damaging	1	neutral	0.41	neutral	2.48	deleterious	-4.28	deleterious	-3.44	high_impact	3.94	0.68	neutral	0.49	neutral	4.51	24.30	deleterious	0.03	0.35	0.45	neutral	0.85	disease	0.58	disease	0.68	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.19	medium_impact	2.25	high_impact	0.64	0.8	14.15	31.17	0.66	P	0.75	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3689	3689	C	G	MI.11551	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	383	128	A	G	gCc/gGc	7.11	1	0	probably_damaging	1	neutral	0.45	neutral	2.55	neutral	-1.94	deleterious	-3.36	medium_impact	2.81	0.75	neutral	0.62	neutral	4.03	23.60	deleterious	0.06	0.35	0.38	neutral	0.81	disease	0.45	neutral	0.62	disease	2	1	deleterious	0.23	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.23	medium_impact	1.27	medium_impact	0.55	0.8	14.15	31.17	0.59	P	0.36	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3689	3689	C	A	MI.11552	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	383	128	A	D	gCc/gAc	7.11	1	0	probably_damaging	1	neutral	0.17	neutral	2.47	deleterious	-4.37	deleterious	-4.9	high_impact	4.5	0.73	neutral	0.38	neutral	4.53	24.30	deleterious	0.01	0.35	0.67	disease	0.93	disease	0.72	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.11	medium_impact	2.74	high_impact	0.39	0.8	14.15	31.17	0.72	P	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3691	3691	C	G	MI.11553	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	385	129	L	V	Ctg/Gtg	-5.98	0	0	probably_damaging	1	neutral	0.48	neutral	2.26	neutral	-2.78	deleterious	-2.66	medium_impact	3.21	0.66	neutral	0.13	damaging	3.44	23.00	deleterious	0.26	0.45	0.27	neutral	0.66	disease	0.46	neutral	0.47	neutral	1	1	deleterious	0.24	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.26	medium_impact	1.62	medium_impact	0.73	0.85	57.23	9.85	0.27	N	0.84	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3691	3691	C	A	MI.11554	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	385	129	L	M	Ctg/Atg	-5.98	0	0	probably_damaging	1	neutral	0.21	neutral	2.27	neutral	-2.63	neutral	-1.66	medium_impact	2.36	0.8	neutral	0.6	neutral	3.75	23.30	deleterious	0.26	0.45	0.36	neutral	0.59	disease	0.27	neutral	0.21	neutral	6	1	deleterious	0.11	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	-0.05	medium_impact	0.87	medium_impact	0.61	0.8	57.23	9.85	0.39	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3692	3692	T	C	MI.11555	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	386	129	L	P	cTg/cCg	-0.93	0	0	probably_damaging	1	neutral	0.19	neutral	2.15	deleterious	-6.14	deleterious	-6.26	high_impact	4.65	0.74	neutral	0.13	damaging	3.87	23.50	deleterious	0.01	0.35	0.66	disease	0.87	disease	0.7	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.08	medium_impact	2.87	high_impact	0.28	0.8	57.23	9.85	0.45	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3692	3692	T	G	MI.11556	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	386	129	L	R	cTg/cGg	-0.93	0	0	probably_damaging	1	neutral	0.33	neutral	2.16	deleterious	-5.55	deleterious	-5.35	high_impact	4.3	0.73	neutral	0.12	damaging	4.18	23.80	deleterious	0.01	0.35	0.56	disease	0.88	disease	0.7	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.1	medium_impact	2.57	high_impact	0.16	0.8	57.23	9.85	0.39	N	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3692	3692	T	A	MI.11557	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	386	129	L	Q	cTg/cAg	-0.93	0	0	probably_damaging	1	neutral	0.27	neutral	2.16	deleterious	-5.51	deleterious	-5.32	high_impact	4.65	0.71	neutral	0.13	damaging	4.18	23.80	deleterious	0.02	0.35	0.57	disease	0.85	disease	0.58	disease	0.67	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.03	medium_impact	2.87	high_impact	0.28	0.8	57.23	9.85	0.46	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3694	3694	A	C	MI.11558	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	388	130	I	L	Atc/Ctc	-0.7	0.02	0	benign	0.26	neutral	0.68	neutral	3.17	neutral	1.25	neutral	-1.13	neutral_impact	0.65	0.8	neutral	0.19	damaging	3.74	23.30	deleterious	0.28	0.45	0.13	neutral	0.26	neutral	0.16	neutral	0.41	neutral	2	0.22	neutral	0.71	deleterious	-6	neutral	0.21	neutral	-0.32	medium_impact	0.46	medium_impact	-0.62	medium_impact	0.52	0.8	22.01	25.8	0.31	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3694	3694	A	G	MI.11559	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	388	130	I	V	Atc/Gtc	-0.7	0.02	0	possibly_damaging	0.53	neutral	0.44	neutral	2.69	neutral	-0.66	neutral	-0.69	medium_impact	2.82	0.8	neutral	0.24	damaging	2.97	22.10	deleterious	0.36	0.5	0.23	neutral	0.36	neutral	0.33	neutral	0.43	neutral	1	0.56	neutral	0.46	neutral	0	NA	0.34	neutral	-0.8	medium_impact	0.22	medium_impact	1.27	medium_impact	0.43	0.8	22.01	25.8	0.33	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9070	9070	T	A	MI.1156	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	544	182	S	T	Tca/Aca	-8.43	0	0	benign	0.35	neutral	0.39	neutral	4.54	neutral	-1.35	neutral	0.22	neutral_impact	0.46	0.92	neutral	0.97	neutral	0.77	9.25	deleterious	0.41	0.65	0.48	neutral	0.14	neutral	0.3	neutral	0.29	neutral	4	0.54	neutral	0.52	deleterious	-6	neutral	0.31	neutral	-0.5	medium_impact	0.18	medium_impact	-0.7	medium_impact	0.86	0.9	23.45	17.69	0.45	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3694	3694	A	T	MI.11560	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	388	130	I	F	Atc/Ttc	-0.7	0.02	0	possibly_damaging	0.89	neutral	0.64	neutral	2.53	neutral	-2.75	neutral	-2.5	medium_impact	2.78	0.85	neutral	0.82	neutral	2.64	20.40	deleterious	0.07	0.35	0.39	neutral	0.8	disease	0.34	neutral	0.25	neutral	5	0.87	neutral	0.38	neutral	0	NA	0.71	deleterious	-1.6	low_impact	0.42	medium_impact	1.24	medium_impact	0.49	0.8	22.01	25.8	0.3	N	0.12	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3695	3695	T	C	MI.11561	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	389	130	I	T	aTc/aCc	2.29	0.57	0	possibly_damaging	0.88	neutral	0.34	neutral	2.51	deleterious	-3.26	deleterious	-3.76	high_impact	3.51	0.7	neutral	0.21	damaging	3.39	23.00	deleterious	0.04	0.35	0.46	neutral	0.71	disease	0.58	disease	0.65	disease	3	0.89	neutral	0.23	neutral	1	deleterious	0.67	deleterious	-1.56	low_impact	0.11	medium_impact	1.88	medium_impact	0.23	0.8	22.01	25.8	0.4	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3695	3695	T	G	MI.11562	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	389	130	I	S	aTc/aGc	2.29	0.57	0	probably_damaging	0.91	neutral	0.7	neutral	2.5	deleterious	-3.97	deleterious	-4.45	medium_impact	3.09	0.74	neutral	0.16	damaging	4.29	24.00	deleterious	0.02	0.35	0.44	neutral	0.85	disease	0.6	disease	0.7	disease	4	0.89	neutral	0.4	neutral	1	deleterious	0.75	deleterious	-1.69	low_impact	0.48	medium_impact	1.51	medium_impact	0.31	0.8	22.01	25.8	0.31	N	0.94	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3695	3695	T	A	MI.11563	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	389	130	I	N	aTc/aAc	2.29	0.57	0	probably_damaging	0.97	neutral	0.48	neutral	2.48	deleterious	-4.99	deleterious	-5.37	high_impact	4.06	0.71	neutral	0.15	damaging	4.42	24.20	deleterious	0.04	0.35	0.71	disease	0.87	disease	0.62	disease	0.7	disease	4	0.97	neutral	0.26	neutral	2	deleterious	0.81	deleterious	-2.17	low_impact	0.26	medium_impact	2.36	high_impact	0.36	0.8	22.01	25.8	0.4	N	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3696	3696	C	A	MI.11564	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	390	130	I	M	atC/atA	2.29	0.57	0.01	possibly_damaging	0.52	neutral	0.22	neutral	2.54	neutral	-2.42	neutral	-1.28	low_impact	1.16	0.83	neutral	0.7	neutral	2.63	20.40	deleterious	0.16	0.45	0.24	neutral	0.39	neutral	0.23	neutral	0.44	neutral	1	0.76	neutral	0.35	neutral	-3	neutral	0.26	neutral	-0.78	medium_impact	-0.03	medium_impact	-0.18	medium_impact	0.48	0.8	22.01	25.8	0.42	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3696	3696	C	G	MI.11565	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	390	130	I	M	atC/atG	2.29	0.57	0.01	possibly_damaging	0.52	neutral	0.22	neutral	2.54	neutral	-2.42	neutral	-1.28	low_impact	1.16	0.83	neutral	0.7	neutral	2.13	17.03	deleterious	0.16	0.45	0.24	neutral	0.39	neutral	0.23	neutral	0.44	neutral	1	0.76	neutral	0.35	neutral	-3	neutral	0.26	neutral	-0.78	medium_impact	-0.03	medium_impact	-0.18	medium_impact	0.48	0.8	22.01	25.8	0.43	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3697	3697	G	T	MI.11566	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	391	131	G	C	Ggc/Tgc	-8.05	0	0	probably_damaging	1	neutral	0.16	neutral	1.9	deleterious	-8.74	deleterious	-8.18	high_impact	4.94	0.67	neutral	0.09	damaging	4.10	23.70	deleterious	0.01	0.35	0.86	disease	0.92	disease	0.67	disease	0.67	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.13	medium_impact	3.13	high_impact	0.24	0.8	59.75	10.46	0.52	N	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3697	3697	G	C	MI.11567	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	391	131	G	R	Ggc/Cgc	-8.05	0	0	probably_damaging	1	neutral	0.32	neutral	1.92	deleterious	-8.91	deleterious	-7.26	high_impact	4.94	0.77	neutral	0.13	damaging	3.86	23.50	deleterious	0.02	0.35	0.85	disease	0.9	disease	0.78	disease	0.72	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.09	medium_impact	3.13	high_impact	0.52	0.8	59.75	10.46	0.66	P	0.99	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3697	3697	G	A	MI.11568	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	391	131	G	S	Ggc/Agc	-8.05	0	0	probably_damaging	1	neutral	0.59	neutral	1.99	deleterious	-5.32	deleterious	-5.44	medium_impact	3.36	0.63	neutral	0.14	damaging	4.16	23.80	deleterious	0.02	0.35	0.46	neutral	0.89	disease	0.64	disease	0.7	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.85	deleterious	-3.57	low_impact	0.36	medium_impact	1.75	medium_impact	0.56	0.8	59.75	10.46	0.36	N	0.99	disease_causing_automatic	0	0.26	rs199476122	Pathogenic	Leber's_optic_atrophy|Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke|Leber_hereditary_optic_neuropathy_with_dystonia	24772	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003|MedGen:C1839040,OMIM:500001	.	COSM6119904	.	.	G3697A	MELAS / LS / LDYT	+	+	Cfrm	11	P	P	P	damaging
chrM	3698	3698	G	A	MI.11569	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	392	131	G	D	gGc/gAc	7.11	1	0	probably_damaging	1	neutral	0.19	neutral	1.93	deleterious	-8.29	deleterious	-6.36	high_impact	4.94	0.7	neutral	0.11	damaging	3.81	23.40	deleterious	0.02	0.35	0.81	disease	0.92	disease	0.77	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.08	medium_impact	3.13	high_impact	0.22	0.8	59.75	10.46	0.73	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9070	9070	T	G	MI.1157	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	544	182	S	A	Tca/Gca	-8.43	0	0	benign	0.2	neutral	0.39	neutral	4.6	neutral	-0.5	neutral	-0.12	neutral_impact	0.68	0.94	neutral	0.93	neutral	0.83	9.63	deleterious	0.49	0.65	0.43	neutral	0.15	neutral	0.4	neutral	0.33	neutral	3	0.53	neutral	0.6	deleterious	-6	neutral	0.21	neutral	-0.18	medium_impact	0.18	medium_impact	-0.52	medium_impact	0.75	0.9	23.45	17.69	0.42	N	0.17	polymorphism	1	0.01	rs879190502	.	.	.	.	pancreatic cancer cell line	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3698	3698	G	C	MI.11570	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	392	131	G	A	gGc/gCc	7.11	1	0	probably_damaging	1	neutral	0.52	neutral	2.05	deleterious	-5.54	deleterious	-5.44	high_impact	3.7	0.64	neutral	0.15	damaging	3.17	22.70	deleterious	0.02	0.35	0.43	neutral	0.74	disease	0.6	disease	0.65	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.29	medium_impact	2.04	high_impact	0.36	0.8	59.75	10.46	0.56	P	0.76	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3698	3698	G	T	MI.11571	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	392	131	G	V	gGc/gTc	7.11	1	0	probably_damaging	1	neutral	0.46	neutral	1.93	deleterious	-7.88	deleterious	-8.17	high_impact	4.94	0.54	damaging	0.11	damaging	3.79	23.40	deleterious	0.02	0.35	0.77	disease	0.9	disease	0.67	disease	0.71	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.24	medium_impact	3.13	high_impact	0.23	0.8	59.75	10.46	0.62	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3700	3700	G	C	MI.11572	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	394	132	A	P	Gca/Cca	-4.15	0	0	probably_damaging	0.97	neutral	0.2	neutral	2.39	deleterious	-3.99	deleterious	-4.45	high_impact	4.47	0.71	neutral	0.57	neutral	3.59	23.20	deleterious	0.02	0.35	0.7	disease	0.93	disease	0.66	disease	0.75	disease	5	0.98	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-2.17	low_impact	-0.06	medium_impact	2.72	high_impact	0.54	0.8	58.18	10.01	0.52	N	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3700	3700	G	T	MI.11573	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	394	132	A	S	Gca/Tca	-4.15	0	0	possibly_damaging	0.78	neutral	0.42	neutral	2.56	neutral	-1.29	deleterious	-2.56	low_impact	1.14	0.79	neutral	0.6	neutral	1.90	15.59	deleterious	0.12	0.4	0.24	neutral	0.77	disease	0.22	neutral	0.4	neutral	2	0.78	neutral	0.32	neutral	-3	neutral	0.68	deleterious	-1.27	low_impact	0.2	medium_impact	-0.19	medium_impact	0.53	0.8	58.18	10.01	0.32	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3700	3700	G	A	MI.11574	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	394	132	A	T	Gca/Aca	-4.15	0	0	benign	0.15	neutral	0.38	neutral	2.45	neutral	-2.46	deleterious	-3.51	high_impact	3.77	0.62	neutral	0.49	neutral	2.27	17.98	deleterious	0.04	0.35	0.47	neutral	0.86	disease	0.42	neutral	0.69	disease	4	0.55	neutral	0.62	deleterious	-2	neutral	0.35	neutral	-0.04	medium_impact	0.16	medium_impact	2.1	high_impact	0.56	0.8	58.18	10.01	0.53	P	0.70	disease_causing_automatic	0	0.18	rs397515508	Pathogenic	Abnormal_electroretinogram|Visual_loss|Leber's_optic_atrophy|Optic_neuropathy	76427	Human_Phenotype_Ontology:HP:0000512,MedGen:C1849688|Human_Phenotype_Ontology:HP:0000572,MedGen:C3665386|Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|Human_Phenotype_Ontology:HP:0001138,MedGen:C3887709	.	.	CPD	0.15	G3700A	LHON	+	-	Cfrm	2	P	P	P	damaging
chrM	3701	3701	C	G	MI.11575	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	395	132	A	G	gCa/gGa	5.73	1	0	possibly_damaging	0.84	neutral	0.33	neutral	2.61	neutral	-0.93	deleterious	-3.53	low_impact	1.9	0.77	neutral	0.58	neutral	2.15	17.17	deleterious	0.08	0.35	0.23	neutral	0.63	disease	0.23	neutral	0.35	neutral	3	0.86	neutral	0.25	neutral	-3	neutral	0.66	deleterious	-1.43	low_impact	0.1	medium_impact	0.47	medium_impact	0.58	0.8	58.18	10.01	0.59	P	0.79	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3701	3701	C	A	MI.11576	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	395	132	A	E	gCa/gAa	5.73	1	0	probably_damaging	0.93	neutral	0.27	neutral	2.4	deleterious	-3.5	deleterious	-4.42	high_impact	4.47	0.72	neutral	0.44	neutral	2.79	21.30	deleterious	0.02	0.35	0.6	disease	0.93	disease	0.64	disease	0.72	disease	4	0.95	neutral	0.17	neutral	2	deleterious	0.85	deleterious	-1.81	low_impact	0.03	medium_impact	2.72	high_impact	0.37	0.8	58.18	10.01	0.72	P	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3701	3701	C	T	MI.11577	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	395	132	A	V	gCa/gTa	5.73	1	0	possibly_damaging	0.78	neutral	0.49	neutral	2.42	deleterious	-3.08	deleterious	-3.59	high_impact	3.77	0.77	neutral	0.52	neutral	2.65	20.50	deleterious	0.04	0.35	0.5	neutral	0.87	disease	0.53	disease	0.69	disease	4	0.76	neutral	0.36	neutral	1	deleterious	0.72	deleterious	-1.27	low_impact	0.27	medium_impact	2.1	high_impact	0.57	0.8	58.18	10.01	0.66	P	0.72	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3703	3703	C	G	MI.11578	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	397	133	L	V	Ctg/Gtg	-3.46	0	0	probably_damaging	1	neutral	0.49	neutral	2.18	neutral	-2.47	deleterious	-2.65	medium_impact	2.42	0.69	neutral	0.12	damaging	3.45	23.00	deleterious	0.27	0.45	0.29	neutral	0.63	disease	0.34	neutral	0.4	neutral	2	1	deleterious	0.25	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.27	medium_impact	0.93	medium_impact	0.62	0.8	59.43	9.84	0.24	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3703	3703	C	A	MI.11579	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	397	133	L	M	Ctg/Atg	-3.46	0	0	probably_damaging	1	neutral	0.22	neutral	2.1	deleterious	-3.33	neutral	-1.76	low_impact	1.86	0.8	neutral	0.17	damaging	3.81	23.40	deleterious	0.27	0.45	0.32	neutral	0.5	neutral	0.18	neutral	0.22	neutral	6	1	deleterious	0.11	neutral	-2	neutral	0.72	deleterious	-3.57	low_impact	-0.03	medium_impact	0.44	medium_impact	0.50	0.8	59.43	9.84	0.4	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9071	9071	C	T	MI.1158	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	545	182	S	L	tCa/tTa	-4.96	0	0	benign	0.01	neutral	1	neutral	4.6	neutral	-0.87	neutral	1.6	neutral_impact	-0.55	0.97	neutral	0.95	neutral	0.03	2.90	deleterious	0.36	0.65	0.39	neutral	0.22	neutral	0.28	neutral	0.38	neutral	2	0.01	neutral	1	deleterious	-6	neutral	0.08	neutral	1.14	medium_impact	1.98	high_impact	-1.57	low_impact	0.86	0.9	23.45	17.69	0.21	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	3.26	C9071T	Potentially functional variant cosegregating with LHON3635A	+	-	Reported	1	.	P	P	neutral
chrM	3704	3704	T	A	MI.11580	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	398	133	L	Q	cTg/cAg	-0.24	0	0	probably_damaging	1	neutral	0.28	neutral	2.02	deleterious	-6.04	deleterious	-5.42	high_impact	4.21	0.73	neutral	0.12	damaging	4.23	23.90	deleterious	0.02	0.35	0.63	disease	0.83	disease	0.49	neutral	0.65	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.05	medium_impact	2.49	high_impact	0.20	0.8	59.43	9.84	0.35	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3704	3704	T	G	MI.11581	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	398	133	L	R	cTg/cGg	-0.24	0	0	probably_damaging	1	neutral	0.35	neutral	2.02	deleterious	-6.08	deleterious	-5.43	high_impact	4.56	0.76	neutral	0.11	damaging	4.17	23.80	deleterious	0.01	0.35	0.62	disease	0.88	disease	0.63	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.12	medium_impact	2.79	high_impact	0.13	0.8	59.43	9.84	0.42	N	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3704	3704	T	C	MI.11582	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	398	133	L	P	cTg/cCg	-0.24	0	0	probably_damaging	1	neutral	0.2	neutral	2.01	deleterious	-6.64	deleterious	-6.33	high_impact	4.56	0.76	neutral	0.12	damaging	3.95	23.60	deleterious	0.01	0.35	0.71	disease	0.86	disease	0.63	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.06	medium_impact	2.79	high_impact	0.24	0.8	59.43	9.84	0.42	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3706	3706	C	G	MI.11583	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	400	134	R	G	Cga/Gga	-6.67	0	0	probably_damaging	1	neutral	0.36	neutral	1.63	deleterious	-10.68	deleterious	-6.38	high_impact	4.96	0.43	damaging	0.04	damaging	4.21	23.90	deleterious	0.02	0.35	0.88	disease	0.87	disease	0.76	disease	0.68	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.14	medium_impact	3.14	high_impact	0.05	0.8	59.43	10.47	0.51	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3706	3706	C	T	MI.11584	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	400	134	R	W	Cga/Tga	-6.67	0	0	probably_damaging	1	neutral	0.18	neutral	1.6	deleterious	-13.24	deleterious	-7.29	high_impact	4.96	0.49	damaging	0.02	damaging	5.13	25.40	deleterious	0.04	0.35	0.97	disease	0.92	disease	0.76	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.09	medium_impact	3.14	high_impact	0.40	0.8	59.43	10.47	0.55	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3707	3707	G	C	MI.11585	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	401	134	R	P	cGa/cCa	5.27	1	0	probably_damaging	1	neutral	0.19	neutral	1.61	deleterious	-11.46	deleterious	-6.38	high_impact	4.96	0.51	damaging	0.02	damaging	4.28	24.00	deleterious	0.01	0.35	0.92	disease	0.92	disease	0.84	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	-0.08	medium_impact	3.14	high_impact	0.07	0.8	59.43	10.47	0.62	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3707	3707	G	T	MI.11586	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	401	134	R	L	cGa/cTa	5.27	1	0	probably_damaging	1	neutral	0.71	neutral	1.63	deleterious	-11.02	deleterious	-6.38	high_impact	4.96	0.45	damaging	0.02	damaging	4.40	24.10	deleterious	0.02	0.35	0.89	disease	0.95	disease	0.74	disease	0.69	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.49	medium_impact	3.14	high_impact	0.06	0.8	59.43	10.47	0.65	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3707	3707	G	A	MI.11587	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	401	134	R	Q	cGa/cAa	5.27	1	0	probably_damaging	1	neutral	0.28	neutral	1.65	deleterious	-10.32	deleterious	-3.64	high_impact	4.62	0.34	damaging	0.02	damaging	4.48	24.30	deleterious	0.05	0.35	0.84	disease	0.88	disease	0.77	disease	0.69	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.05	medium_impact	2.85	high_impact	0.72	0.85	59.43	10.47	0.75	P	1.00	polymorphism	0.96	0.48	.	.	.	.	.	.	COSM1138351	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3709	3709	G	T	MI.11588	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	403	135	A	S	Gca/Tca	-0.24	0.66	0	probably_damaging	1	neutral	0.42	neutral	2.44	neutral	-1.38	deleterious	-2.69	low_impact	1.86	0.7	neutral	0.09	damaging	3.70	23.30	deleterious	0.27	0.45	0.17	neutral	0.77	disease	0.2	neutral	0.22	neutral	6	1	deleterious	0.21	neutral	-2	neutral	0.79	deleterious	-3.57	low_impact	0.2	medium_impact	0.44	medium_impact	0.33	0.8	59.12	10.41	0.29	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3709	3709	G	A	MI.11589	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	403	135	A	T	Gca/Aca	-0.24	0.66	0	probably_damaging	1	neutral	0.37	neutral	2.24	deleterious	-3.2	deleterious	-3.61	medium_impact	3.12	0.65	neutral	0.07	damaging	4.18	23.80	deleterious	0.12	0.4	0.26	neutral	0.87	disease	0.52	disease	0.69	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.81	deleterious	-3.57	low_impact	0.15	medium_impact	1.54	medium_impact	0.75	0.85	59.12	10.41	0.34	N	0.70	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9071	9071	C	G	MI.1159	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	545	182	S	W	tCa/tGa	-4.96	0	0	probably_damaging	0.91	neutral	0.09	neutral	4.5	deleterious	-3.04	neutral	-1.55	medium_impact	2.25	0.86	neutral	0.45	neutral	4.31	24.00	deleterious	0.22	0.65	0.82	disease	0.65	disease	0.48	neutral	0.54	disease	1	0.97	neutral	0.09	neutral	1	deleterious	0.72	deleterious	-1.71	low_impact	-0.28	medium_impact	0.83	medium_impact	0.61	0.9	23.45	17.69	0.33	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3709	3709	G	C	MI.11590	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	403	135	A	P	Gca/Cca	-0.24	0.66	0	probably_damaging	1	neutral	0.19	neutral	2.18	deleterious	-4.68	deleterious	-4.54	high_impact	4.58	0.73	neutral	0.06	damaging	3.83	23.40	deleterious	0.03	0.35	0.54	disease	0.92	disease	0.67	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.08	medium_impact	2.81	high_impact	0.50	0.8	59.12	10.41	0.47	N	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3710	3710	C	G	MI.11591	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	404	135	A	G	gCa/gGa	8.95	1	0	probably_damaging	1	neutral	0.42	neutral	2.22	deleterious	-3.53	deleterious	-3.62	medium_impact	2.48	0.73	neutral	0.11	damaging	3.91	23.50	deleterious	0.2	0.45	0.45	neutral	0.83	disease	0.36	neutral	0.27	neutral	5	1	deleterious	0.21	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.2	medium_impact	0.98	medium_impact	0.61	0.8	59.12	10.41	0.52	N	0.79	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3710	3710	C	T	MI.11592	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	404	135	A	V	gCa/gTa	8.95	1	0	probably_damaging	1	neutral	0.52	neutral	2.2	deleterious	-3.86	deleterious	-3.64	medium_impact	3.2	0.66	neutral	0.07	damaging	4.40	24.10	deleterious	0.09	0.35	0.43	neutral	0.89	disease	0.55	disease	0.68	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	0.29	medium_impact	1.61	medium_impact	0.54	0.8	59.12	10.41	0.55	P	0.72	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3710	3710	C	A	MI.11593	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	404	135	A	E	gCa/gAa	8.95	1	0	probably_damaging	1	neutral	0.26	neutral	2.2	deleterious	-4.09	deleterious	-4.52	high_impact	4.24	0.76	neutral	0.08	damaging	4.48	24.20	deleterious	0.05	0.35	0.18	neutral	0.93	disease	0.65	disease	0.72	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.02	medium_impact	2.51	high_impact	0.26	0.8	59.12	10.41	0.59	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3712	3712	G	A	MI.11594	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	406	136	V	M	Gta/Ata	-2.08	0	0	probably_damaging	1	neutral	0.22	neutral	2.53	neutral	-0.87	deleterious	-2.7	medium_impact	2.98	0.67	neutral	0.55	neutral	3.68	23.30	deleterious	0.21	0.45	0.29	neutral	0.79	disease	0.57	disease	0.56	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	-0.03	medium_impact	1.41	medium_impact	0.98	1	59.12	10.42	0.39	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3712	3712	G	C	MI.11595	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	406	136	V	L	Gta/Cta	-2.08	0	0	probably_damaging	1	neutral	0.66	neutral	2.58	neutral	0.22	deleterious	-2.68	medium_impact	2.56	0.71	neutral	0.5	neutral	3.54	23.10	deleterious	0.18	0.45	0.19	neutral	0.82	disease	0.52	disease	0.67	disease	3	1	deleterious	0.33	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.44	medium_impact	1.05	medium_impact	0.73	0.85	59.12	10.42	0.3	N	0.71	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3712	3712	G	T	MI.11596	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	406	136	V	L	Gta/Tta	-2.08	0	0	probably_damaging	1	neutral	0.66	neutral	2.58	neutral	0.22	deleterious	-2.68	medium_impact	2.56	0.71	neutral	0.5	neutral	3.64	23.20	deleterious	0.18	0.45	0.19	neutral	0.82	disease	0.52	disease	0.67	disease	3	1	deleterious	0.33	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.44	medium_impact	1.05	medium_impact	0.73	0.85	59.12	10.42	0.3	N	0.71	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3713	3713	T	C	MI.11597	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	407	136	V	A	gTa/gCa	7.11	1	0	probably_damaging	1	neutral	0.52	neutral	2.81	neutral	0.61	deleterious	-3.64	medium_impact	2.12	0.73	neutral	0.6	neutral	3.57	23.10	deleterious	0.12	0.4	0.15	neutral	0.53	disease	0.35	neutral	0.21	neutral	6	1	deleterious	0.26	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.29	medium_impact	0.66	medium_impact	0.28	0.8	59.12	10.42	0.57	P	0.64	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	T3713C	LHON	+	-	Reported	1	.	P	P	neutral
chrM	3713	3713	T	G	MI.11598	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	407	136	V	G	gTa/gGa	7.11	1	0	probably_damaging	1	neutral	0.34	neutral	2.55	neutral	-2.46	deleterious	-6.37	high_impact	3.65	0.71	neutral	0.55	neutral	3.81	23.40	deleterious	0.03	0.35	0.46	neutral	0.88	disease	0.61	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.11	medium_impact	2	medium_impact	0.21	0.8	59.12	10.42	0.65	P	0.95	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3713	3713	T	A	MI.11599	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	407	136	V	E	gTa/gAa	7.11	1	0	probably_damaging	1	neutral	0.27	neutral	2.54	neutral	-2.98	deleterious	-5.47	high_impact	4.21	0.72	neutral	0.46	neutral	4.89	24.90	deleterious	0.02	0.35	0.55	disease	0.91	disease	0.7	disease	0.73	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.03	medium_impact	2.49	high_impact	0.17	0.8	59.12	10.42	0.7	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8579	8579	C	A	MI.116	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	53	18	P	H	cCc/cAc	1.29	0.83	0	probably_damaging	1	deleterious	0.03	neutral	4.57	neutral	-0.99	deleterious	-7.7	medium_impact	3.1	0.74	neutral	0.43	neutral	3.84	23.40	deleterious	0.3	0.65	0.8	disease	0.86	disease	0.72	disease	0.78	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-0.56	medium_impact	1.56	medium_impact	0.65	0.9	21.24	15.57	0.33	N	0.91	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9073	9073	A	G	MI.1160	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	547	183	T	A	Acc/Gcc	-1.95	0	0	benign	0.02	neutral	0.51	neutral	4.69	neutral	0.54	neutral	-0.86	neutral_impact	0.26	0.97	neutral	0.86	neutral	2.59	20.20	deleterious	0.67	0.75	0.26	neutral	0.29	neutral	0.42	neutral	0.43	neutral	1	0.47	neutral	0.75	deleterious	-6	neutral	0.14	neutral	0.85	medium_impact	0.3	medium_impact	-0.88	medium_impact	0.48	0.9	15.04	22.29	0.28	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3715	3715	G	T	MI.11600	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	409	137	A	S	Gcc/Tcc	-8.05	0	0	probably_damaging	1	neutral	0.41	neutral	2.18	neutral	-2.45	deleterious	-2.73	medium_impact	2.79	0.58	damaging	0.05	damaging	3.68	23.30	deleterious	0.18	0.45	0.32	neutral	0.87	disease	0.48	neutral	0.57	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.82	deleterious	-3.57	low_impact	0.19	medium_impact	1.25	medium_impact	0.55	0.8	59.12	10.53	0.27	N	0.93	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3715	3715	G	A	MI.11601	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	409	137	A	T	Gcc/Acc	-8.05	0	0	probably_damaging	1	neutral	0.3	neutral	2.07	deleterious	-3.62	deleterious	-3.63	high_impact	4.32	0.58	damaging	0.03	damaging	4.22	23.90	deleterious	0.08	0.35	0.3	neutral	0.85	disease	0.61	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.07	medium_impact	2.58	high_impact	0.71	0.85	59.12	10.53	0.35	N	0.70	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3715	3715	G	C	MI.11602	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	409	137	A	P	Gcc/Ccc	-8.05	0	0	probably_damaging	1	neutral	0.14	neutral	2.02	deleterious	-5.1	deleterious	-4.55	high_impact	3.98	0.6	neutral	0.03	damaging	3.76	23.30	deleterious	0.02	0.35	0.66	disease	0.91	disease	0.74	disease	0.74	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.17	medium_impact	2.29	high_impact	0.55	0.8	59.12	10.53	0.35	N	0.96	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3716	3716	C	G	MI.11603	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	410	137	A	G	gCc/gGc	5.73	1	0	probably_damaging	1	neutral	0.54	neutral	2.06	deleterious	-3.94	deleterious	-3.65	high_impact	3.98	0.64	neutral	0.05	damaging	3.95	23.60	deleterious	0.1	0.4	0.52	disease	0.86	disease	0.62	disease	0.7	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.31	medium_impact	2.29	high_impact	0.62	0.8	59.12	10.53	0.58	P	0.79	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3716	3716	C	T	MI.11604	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	410	137	A	V	gCc/gTc	5.73	1	0	probably_damaging	1	neutral	0.43	neutral	2.04	deleterious	-4.23	deleterious	-3.62	high_impact	3.83	0.7	neutral	0.07	damaging	4.41	24.20	deleterious	0.06	0.35	0.32	neutral	0.89	disease	0.61	disease	0.69	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.21	medium_impact	2.16	high_impact	0.63	0.8	59.12	10.53	0.59	P	0.72	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3716	3716	C	A	MI.11605	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	410	137	A	D	gCc/gAc	5.73	1	0	probably_damaging	1	neutral	0.15	neutral	2.02	deleterious	-4.92	deleterious	-5.46	high_impact	4.87	0.65	neutral	0.02	damaging	4.60	24.40	deleterious	0.02	0.35	0.63	disease	0.94	disease	0.73	disease	0.82	disease	6	1	deleterious	0.08	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.15	medium_impact	3.06	high_impact	0.31	0.8	59.12	10.53	0.74	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3718	3718	C	G	MI.11606	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	412	138	Q	E	Caa/Gaa	-5.07	0	0	probably_damaging	1	neutral	0.21	neutral	2.34	neutral	-2.89	deleterious	-2.73	high_impact	4.93	0.69	neutral	0.3	neutral	3.03	22.30	deleterious	0.16	0.45	0.42	neutral	0.84	disease	0.75	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.05	medium_impact	3.12	high_impact	0.28	0.8	60.06	10.45	0.73	P	0.93	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3718	3718	C	A	MI.11607	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	412	138	Q	K	Caa/Aaa	-5.07	0	0	probably_damaging	1	neutral	0.22	neutral	2.37	neutral	-2.4	deleterious	-3.64	high_impact	4.58	0.67	neutral	0.26	damaging	3.89	23.50	deleterious	0.09	0.35	0.39	neutral	0.9	disease	0.75	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.03	medium_impact	2.81	high_impact	0.18	0.8	60.06	10.45	0.55	N	0.98	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3719	3719	A	T	MI.11608	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	413	138	Q	L	cAa/cTa	7.11	1	0	probably_damaging	1	neutral	0.83	neutral	2.34	neutral	-2.79	deleterious	-6.37	high_impact	3.96	0.67	neutral	0.32	neutral	3.78	23.40	deleterious	0.04	0.35	0.18	neutral	0.92	disease	0.67	disease	0.72	disease	4	1	deleterious	0.42	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.66	medium_impact	2.27	high_impact	0.12	0.8	60.06	10.45	0.54	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3719	3719	A	G	MI.11609	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	413	138	Q	R	cAa/cGa	7.11	1	0	probably_damaging	1	neutral	0.49	neutral	2.34	neutral	-2.84	deleterious	-3.64	high_impact	4.04	0.68	neutral	0.26	damaging	3.41	23.00	deleterious	0.09	0.35	0.41	neutral	0.9	disease	0.77	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.27	medium_impact	2.34	high_impact	0.17	0.8	60.06	10.45	0.67	P	0.95	polymorphism	0.98	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9073	9073	A	T	MI.1161	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	547	183	T	S	Acc/Tcc	-1.95	0	0	benign	0.28	neutral	0.55	neutral	4.67	neutral	0.03	neutral	0.53	neutral_impact	-1.31	0.91	neutral	0.96	neutral	1.20	11.73	neutral	0.51	0.65	0.31	neutral	0.17	neutral	0.23	neutral	0.25	neutral	5	0.35	neutral	0.64	deleterious	-6	neutral	0.35	neutral	-0.37	medium_impact	0.34	medium_impact	-2.22	low_impact	0.56	0.9	15.04	22.29	0.32	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3719	3719	A	C	MI.11610	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	413	138	Q	P	cAa/cCa	7.11	1	0	probably_damaging	1	neutral	0.15	neutral	2.27	deleterious	-4.81	deleterious	-5.44	high_impact	4.58	0.69	neutral	0.32	neutral	3.21	22.70	deleterious	0.03	0.35	0.66	disease	0.91	disease	0.77	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	-0.15	medium_impact	2.81	high_impact	0.13	0.8	60.06	10.45	0.7	P	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3720	3720	A	C	MI.11611	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	414	138	Q	H	caA/caC	6.42	1	0.02	probably_damaging	1	neutral	0.41	neutral	2.28	deleterious	-4.49	deleterious	-4.55	high_impact	4.93	0.59	damaging	0.21	damaging	3.29	22.80	deleterious	0.09	0.35	0.63	disease	0.85	disease	0.79	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.19	medium_impact	3.12	high_impact	0.39	0.8	60.06	10.45	0.82	P	0.98	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3720	3720	A	T	MI.11612	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	414	138	Q	H	caA/caT	6.42	1	0.02	probably_damaging	1	neutral	0.41	neutral	2.28	deleterious	-4.49	deleterious	-4.55	high_impact	4.93	0.59	damaging	0.21	damaging	3.51	23.10	deleterious	0.09	0.35	0.63	disease	0.85	disease	0.79	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.19	medium_impact	3.12	high_impact	0.39	0.8	60.06	10.45	0.83	P	0.98	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3721	3721	A	T	MI.11613	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	415	139	T	S	Aca/Tca	2.06	1	0	possibly_damaging	0.85	neutral	0.6	neutral	2.78	neutral	-0.11	deleterious	-3.62	medium_impact	2.21	0.7	neutral	0.49	neutral	3.15	22.60	deleterious	0.37	0.5	0.18	neutral	0.83	disease	0.49	neutral	0.66	disease	3	0.83	neutral	0.38	neutral	0	NA	0.70	deleterious	-1.46	low_impact	0.37	medium_impact	0.74	medium_impact	0.60	0.8	56.29	9.53	0.46	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3721	3721	A	C	MI.11614	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	415	139	T	P	Aca/Cca	2.06	1	0	probably_damaging	0.98	neutral	0.15	neutral	2.59	neutral	-2.61	deleterious	-5.39	high_impact	4.49	0.76	neutral	0.43	neutral	3.41	23.00	deleterious	0.03	0.35	0.52	disease	0.91	disease	0.75	disease	0.75	disease	5	0.99	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-2.34	low_impact	-0.15	medium_impact	2.73	high_impact	0.29	0.8	56.29	9.53	0.64	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3721	3721	A	G	MI.11615	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	415	139	T	A	Aca/Gca	2.06	1	0	possibly_damaging	0.74	neutral	1	neutral	2.68	neutral	0.06	deleterious	-4.52	medium_impact	3.1	0.68	neutral	0.53	neutral	3.34	22.90	deleterious	0.25	0.45	0.2	neutral	0.72	disease	0.52	disease	0.44	neutral	1	0.74	neutral	0.63	deleterious	0	NA	0.62	deleterious	-1.18	low_impact	1.96	high_impact	1.52	medium_impact	0.30	0.8	56.29	9.53	0.44	N	0.65	polymorphism	1	0.11	rs878927280	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3722	3722	C	A	MI.11616	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	416	139	T	K	aCa/aAa	8.49	1	0	probably_damaging	0.94	neutral	0.32	neutral	2.64	neutral	-1.77	deleterious	-5.43	high_impact	4.14	0.7	neutral	0.33	neutral	4.48	24.20	deleterious	0.05	0.35	0.34	neutral	0.92	disease	0.7	disease	0.75	disease	5	0.95	neutral	0.19	neutral	2	deleterious	0.80	deleterious	-1.87	low_impact	0.09	medium_impact	2.43	high_impact	0.31	0.8	56.29	9.53	0.66	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3722	3722	C	T	MI.11617	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	416	139	T	M	aCa/aTa	8.49	1	0	possibly_damaging	0.52	neutral	0.18	neutral	2.68	neutral	1.89	deleterious	-5.42	low_impact	1.9	0.71	neutral	0.55	neutral	3.92	23.50	deleterious	0.12	0.4	0.14	neutral	0.75	disease	0.32	neutral	0.22	neutral	6	0.8	neutral	0.33	neutral	-3	neutral	0.47	deleterious	-0.78	medium_impact	-0.09	medium_impact	0.47	medium_impact	0.52	0.8	56.29	9.53	0.59	P	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3724	3724	A	T	MI.11618	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	418	140	I	F	Atc/Ttc	-8.28	0	0	probably_damaging	1	neutral	0.7	neutral	2.18	deleterious	-4.44	deleterious	-3.64	high_impact	4.48	0.68	neutral	0.09	damaging	3.87	23.50	deleterious	0.04	0.35	0.72	disease	0.9	disease	0.69	disease	0.72	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.48	medium_impact	2.72	high_impact	0.63	0.8	59.12	10.2	0.39	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3724	3724	A	G	MI.11619	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	418	140	I	V	Atc/Gtc	-8.28	0	0	probably_damaging	1	neutral	0.67	neutral	2.54	neutral	-0.89	neutral	-0.89	medium_impact	2.46	0.75	neutral	0.16	damaging	2.94	22.00	deleterious	0.59	0.65	0.17	neutral	0.53	disease	0.4	neutral	0.34	neutral	3	1	deleterious	0.34	neutral	1	deleterious	0.69	deleterious	-3.57	low_impact	0.45	medium_impact	0.96	medium_impact	0.63	0.8	59.12	10.2	0.25	N	0.73	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9073	9073	A	C	MI.1162	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	547	183	T	P	Acc/Ccc	-1.95	0	0	possibly_damaging	0.68	neutral	0.32	neutral	4.61	neutral	-0.9	neutral	-0.88	neutral_impact	-1.08	0.76	neutral	0.81	neutral	1.72	14.51	neutral	0.23	0.65	0.25	neutral	0.29	neutral	0.37	neutral	0.42	neutral	2	0.75	neutral	0.32	neutral	-3	neutral	0.61	deleterious	-1.07	low_impact	0.11	medium_impact	-2.02	low_impact	0.71	0.9	15.04	22.29	0.34	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3724	3724	A	C	MI.11620	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	418	140	I	L	Atc/Ctc	-8.28	0	0	probably_damaging	1	neutral	0.84	neutral	2.36	neutral	-1.82	neutral	-1.82	medium_impact	2.68	0.73	neutral	0.08	damaging	3.72	23.30	deleterious	0.25	0.45	0.29	neutral	0.79	disease	0.53	disease	0.65	disease	3	1	deleterious	0.42	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.68	medium_impact	1.15	medium_impact	0.56	0.8	59.12	10.2	0.24	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3725	3725	T	G	MI.11621	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	419	140	I	S	aTc/aGc	8.49	1	0	probably_damaging	1	neutral	0.5	neutral	2.16	deleterious	-5.14	deleterious	-5.44	high_impact	4.83	0.72	neutral	0.12	damaging	4.21	23.90	deleterious	0.01	0.35	0.79	disease	0.92	disease	0.67	disease	0.73	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.28	medium_impact	3.03	high_impact	0.33	0.8	59.12	10.2	0.75	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3725	3725	T	A	MI.11622	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	419	140	I	N	aTc/aAc	8.49	1	0	probably_damaging	1	neutral	0.32	neutral	2.15	deleterious	-6.16	deleterious	-6.36	high_impact	4.48	0.78	neutral	0.12	damaging	4.59	24.40	deleterious	0.03	0.35	0.88	disease	0.91	disease	0.69	disease	0.74	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.09	medium_impact	2.72	high_impact	0.48	0.8	59.12	10.2	0.6	P	1.00	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3725	3725	T	C	MI.11623	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	419	140	I	T	aTc/aCc	8.49	1	0	probably_damaging	1	neutral	0.42	neutral	2.18	deleterious	-4.28	deleterious	-4.52	high_impact	4.83	0.67	neutral	0.09	damaging	3.41	23.00	deleterious	0.02	0.35	0.67	disease	0.82	disease	0.67	disease	0.68	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.2	medium_impact	3.03	high_impact	0.28	0.8	59.12	10.2	0.76	P	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3726	3726	C	G	MI.11624	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	420	140	I	M	atC/atG	5.5	1	0	probably_damaging	1	neutral	0.23	neutral	2.19	deleterious	-4.11	deleterious	-2.72	high_impact	4.48	0.81	neutral	0.14	damaging	3.37	22.90	deleterious	0.12	0.4	0.68	disease	0.79	disease	0.68	disease	0.67	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	-0.02	medium_impact	2.72	high_impact	0.65	0.8	59.12	10.2	0.64	P	0.74	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3726	3726	C	A	MI.11625	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	420	140	I	M	atC/atA	5.5	1	0	probably_damaging	1	neutral	0.23	neutral	2.19	deleterious	-4.11	deleterious	-2.72	high_impact	4.48	0.81	neutral	0.14	damaging	3.78	23.40	deleterious	0.12	0.4	0.68	disease	0.79	disease	0.68	disease	0.67	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	-0.02	medium_impact	2.72	high_impact	0.65	0.8	59.12	10.2	0.65	P	0.74	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3727	3727	T	C	MI.11626	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	421	141	S	P	Tca/Cca	-2.31	0	0	probably_damaging	1	neutral	0.14	neutral	2.03	deleterious	-4.27	deleterious	-4.57	high_impact	4.94	0.73	neutral	0.04	damaging	3.94	23.50	deleterious	0.03	0.35	0.63	disease	0.87	disease	0.82	disease	0.73	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.17	medium_impact	3.13	high_impact	0.31	0.8	58.18	10.4	0.73	P	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3727	3727	T	A	MI.11627	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	421	141	S	T	Tca/Aca	-2.31	0	0	probably_damaging	1	neutral	0.43	neutral	2.06	deleterious	-3.77	deleterious	-2.73	high_impact	4.25	0.62	neutral	0.05	damaging	3.68	23.30	deleterious	0.19	0.45	0.38	neutral	0.71	disease	0.72	disease	0.69	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.21	medium_impact	2.52	high_impact	0.71	0.85	58.18	10.4	0.4	N	0.68	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3727	3727	T	G	MI.11628	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	421	141	S	A	Tca/Gca	-2.31	0	0	probably_damaging	1	neutral	1	neutral	2.11	deleterious	-3.01	deleterious	-2.74	medium_impact	3.46	0.63	neutral	0.11	damaging	3.62	23.20	deleterious	0.2	0.45	0.28	neutral	0.63	disease	0.7	disease	0.68	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.75	deleterious	-3.57	low_impact	1.96	high_impact	1.83	medium_impact	0.49	0.8	58.18	10.4	0.26	N	0.46	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3728	3728	C	G	MI.11629	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	422	141	S	W	tCa/tGa	7.34	1	0	probably_damaging	1	neutral	0.13	neutral	1.98	deleterious	-8.02	deleterious	-6.39	high_impact	4.94	0.7	neutral	0.04	damaging	4.33	24.00	deleterious	0.04	0.35	0.79	disease	0.92	disease	0.76	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.19	medium_impact	3.13	high_impact	0.11	0.8	58.18	10.4	0.69	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9074	9074	C	T	MI.1163	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	548	183	T	I	aCc/aTc	-0.8	0	0	possibly_damaging	0.61	neutral	0.41	neutral	4.64	neutral	-0.87	neutral	-2.48	neutral_impact	0.34	0.92	neutral	0.67	neutral	2.68	20.70	deleterious	0.43	0.65	0.51	disease	0.6	disease	0.45	neutral	0.48	neutral	0	0.64	neutral	0.4	neutral	-3	neutral	0.58	deleterious	-0.94	medium_impact	0.2	medium_impact	-0.81	medium_impact	0.73	0.9	15.04	22.29	0.31	N	0.64	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3728	3728	C	T	MI.11630	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	422	141	S	L	tCa/tTa	7.34	1	0	probably_damaging	1	neutral	0.62	neutral	2.01	deleterious	-4.87	deleterious	-5.48	high_impact	4.13	0.64	neutral	0.02	damaging	4.64	24.50	deleterious	0.03	0.35	0.24	neutral	0.9	disease	0.69	disease	0.71	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.39	medium_impact	2.42	high_impact	0.44	0.8	58.18	10.4	0.54	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3730	3730	T	G	MI.11631	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	424	142	Y	D	Tat/Gat	-3.46	0	0	probably_damaging	1	neutral	0.18	neutral	1.58	deleterious	-6.73	deleterious	-9.13	high_impact	4.93	0.74	neutral	0.13	damaging	3.97	23.60	deleterious	0.02	0.35	0.74	disease	0.93	disease	0.78	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.09	medium_impact	3.12	high_impact	0.06	0.8	58.81	10.47	0.63	P	1.00	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3730	3730	T	A	MI.11632	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	424	142	Y	N	Tat/Aat	-3.46	0	0	probably_damaging	1	neutral	0.26	neutral	1.58	deleterious	-6.45	deleterious	-8.21	high_impact	4.93	0.7	neutral	0.14	damaging	4.03	23.60	deleterious	0.05	0.35	0.65	disease	0.9	disease	0.71	disease	0.72	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.02	medium_impact	3.12	high_impact	0.04	0.8	58.81	10.47	0.58	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3730	3730	T	C	MI.11633	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	424	142	Y	H	Tat/Cat	-3.46	0	0	probably_damaging	1	neutral	0.45	neutral	1.59	deleterious	-5.96	deleterious	-4.57	high_impact	4.93	0.66	neutral	0.12	damaging	3.57	23.20	deleterious	0.1	0.4	0.69	disease	0.88	disease	0.75	disease	0.73	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.23	medium_impact	3.12	high_impact	0.11	0.8	58.81	10.47	0.73	P	1.00	polymorphism	1	0.48	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3731	3731	A	C	MI.11634	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	425	142	Y	S	tAt/tCt	7.34	1	0	probably_damaging	1	neutral	0.54	neutral	1.59	deleterious	-6.02	deleterious	-8.21	high_impact	4.39	0.67	neutral	0.16	damaging	3.64	23.20	deleterious	0.05	0.35	0.4	neutral	0.91	disease	0.7	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.31	medium_impact	2.65	high_impact	0.11	0.8	58.81	10.47	0.53	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3731	3731	A	T	MI.11635	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	425	142	Y	F	tAt/tTt	7.34	1	0	probably_damaging	1	neutral	0.6	neutral	1.7	deleterious	-3.78	deleterious	-3.65	medium_impact	3.12	0.68	neutral	0.17	damaging	3.26	22.80	deleterious	0.15	0.4	0.48	neutral	0.89	disease	0.63	disease	0.69	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.85	deleterious	-3.57	low_impact	0.37	medium_impact	1.54	medium_impact	0.28	0.8	58.81	10.47	0.55	P	0.80	polymorphism	0.99	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3731	3731	A	G	MI.11636	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	425	142	Y	C	tAt/tGt	7.34	1	0	probably_damaging	1	neutral	0.15	neutral	1.57	deleterious	-7.85	deleterious	-8.22	high_impact	4.93	0.74	neutral	0.12	damaging	3.35	22.90	deleterious	0.05	0.35	0.47	neutral	0.9	disease	0.75	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.15	medium_impact	3.12	high_impact	0.06	0.8	58.81	10.47	0.65	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3733	3733	G	C	MI.11637	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	427	143	E	Q	Gaa/Caa	-6.9	0	0	probably_damaging	0.95	neutral	0.6	neutral	1.75	deleterious	-6.3	deleterious	-2.73	high_impact	4.96	0.67	neutral	0.58	neutral	3.35	22.90	deleterious	0.06	0.35	0.84	disease	0.79	disease	0.74	disease	0.7	disease	4	0.95	neutral	0.33	neutral	2	deleterious	0.87	deleterious	-1.95	low_impact	0.37	medium_impact	3.14	high_impact	0.49	0.8	59.43	10.32	0.74	P	0.91	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	G3733C	LHON	-	+	Reported	1	.	P	P	damaging
chrM	3733	3733	G	A	MI.11638	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	427	143	E	K	Gaa/Aaa	-6.9	0	0	possibly_damaging	0.85	neutral	0.23	neutral	1.77	deleterious	-6.28	deleterious	-3.64	high_impact	4.96	0.63	neutral	0.4	neutral	4.47	24.20	deleterious	0.03	0.35	0.82	disease	0.9	disease	0.78	disease	0.71	disease	4	0.9	neutral	0.19	neutral	1	deleterious	0.84	deleterious	-1.46	low_impact	-0.02	medium_impact	3.14	high_impact	0.70	0.85	59.43	10.32	0.79	P	0.99	disease_causing_automatic	0	0.48	rs199476125	Pathogenic	Leber's_optic_atrophy	24775	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	G3733A	LHON	+	+	Cfrm	6	P	P	P	damaging
chrM	3734	3734	A	C	MI.11639	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	428	143	E	A	gAa/gCa	5.73	1	0	possibly_damaging	0.74	neutral	1	neutral	1.75	deleterious	-6.5	deleterious	-5.46	high_impact	4.96	0.68	neutral	0.59	neutral	3.71	23.30	deleterious	0.03	0.35	0.84	disease	0.76	disease	0.73	disease	0.7	disease	4	0.74	neutral	0.63	deleterious	1	deleterious	0.73	deleterious	-1.18	low_impact	1.96	high_impact	3.14	high_impact	0.34	0.8	59.43	10.32	0.7	P	0.74	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9074	9074	C	A	MI.1164	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	548	183	T	N	aCc/aAc	-0.8	0	0	possibly_damaging	0.75	neutral	0.38	neutral	4.61	neutral	-0.96	neutral	-0.95	neutral_impact	-0.06	0.92	neutral	0.96	neutral	2.39	18.73	deleterious	0.56	0.65	0.33	neutral	0.48	neutral	0.28	neutral	0.45	neutral	1	0.76	neutral	0.32	neutral	-3	neutral	0.58	deleterious	-1.21	low_impact	0.17	medium_impact	-1.15	low_impact	0.73	0.9	15.04	22.29	0.38	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3734	3734	A	G	MI.11640	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	428	143	E	G	gAa/gGa	5.73	1	0	benign	0.08	neutral	0.25	neutral	1.74	deleterious	-6.79	deleterious	-6.37	high_impact	4.62	0.7	neutral	0.65	neutral	4.28	24.00	deleterious	0.02	0.35	0.83	disease	0.85	disease	0.75	disease	0.7	disease	4	0.72	neutral	0.59	deleterious	-2	neutral	0.37	neutral	0.25	medium_impact	0.01	medium_impact	2.85	high_impact	0.15	0.8	59.43	10.32	0.63	P	0.61	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3734	3734	A	T	MI.11641	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	428	143	E	V	gAa/gTa	5.73	1	0	probably_damaging	0.96	neutral	0.78	neutral	1.73	deleterious	-7.75	deleterious	-6.38	high_impact	4.96	0.63	neutral	0.53	neutral	4.19	23.80	deleterious	0.02	0.35	0.92	disease	0.91	disease	0.75	disease	0.66	disease	3	0.95	neutral	0.41	neutral	2	deleterious	0.89	deleterious	-2.05	low_impact	0.58	medium_impact	3.14	high_impact	0.23	0.8	59.43	10.32	0.73	P	0.83	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3735	3735	A	T	MI.11642	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	429	143	E	D	gaA/gaT	8.49	1	0	possibly_damaging	0.85	neutral	0.16	neutral	1.8	deleterious	-5.09	deleterious	-2.73	high_impact	4.62	0.71	neutral	0.55	neutral	3.87	23.50	deleterious	0.09	0.35	0.7	disease	0.81	disease	0.75	disease	0.72	disease	4	0.92	neutral	0.16	neutral	1	deleterious	0.77	deleterious	-1.46	low_impact	-0.13	medium_impact	2.85	high_impact	0.53	0.8	59.43	10.32	0.73	P	0.90	polymorphism	0.98	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3735	3735	A	C	MI.11643	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	429	143	E	D	gaA/gaC	8.49	1	0	possibly_damaging	0.85	neutral	0.16	neutral	1.8	deleterious	-5.09	deleterious	-2.73	high_impact	4.62	0.71	neutral	0.55	neutral	3.70	23.30	deleterious	0.09	0.35	0.7	disease	0.81	disease	0.75	disease	0.72	disease	4	0.92	neutral	0.16	neutral	1	deleterious	0.77	deleterious	-1.46	low_impact	-0.13	medium_impact	2.85	high_impact	0.53	0.8	59.43	10.32	0.73	P	0.90	polymorphism	0.98	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3736	3736	G	C	MI.11644	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	430	144	V	L	Gtc/Ctc	4.58	1	0.01	benign	0.39	neutral	0.61	neutral	2.45	neutral	-1.51	deleterious	-2.71	medium_impact	2.62	0.72	neutral	0.49	neutral	1.62	13.94	neutral	0.26	0.45	0.18	neutral	0.82	disease	0.57	disease	0.66	disease	3	0.35	neutral	0.61	deleterious	-3	neutral	0.34	neutral	-0.57	medium_impact	0.38	medium_impact	1.1	medium_impact	0.32	0.8	57.55	10.07	0.52	N	0.69	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3736	3736	G	A	MI.11645	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	430	144	V	I	Gtc/Atc	4.58	1	0.01	benign	0.05	neutral	0.47	neutral	2.66	neutral	-0.5	neutral	-0.89	low_impact	1.92	0.68	neutral	0.6	neutral	1.68	14.29	neutral	0.41	0.5	0.18	neutral	0.58	disease	0.31	neutral	0.2	neutral	6	0.48	neutral	0.71	deleterious	-6	neutral	0.19	neutral	0.45	medium_impact	0.25	medium_impact	0.49	medium_impact	0.72	0.85	57.55	10.07	0.7	P	0.08	polymorphism	1	0.03	rs201513497	.	.	.	.	.	COSM6716703	CPD	0.89	G3736A	LHON	.	.	Reported	1	N	P	N,P	damaging
chrM	3736	3736	G	T	MI.11646	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	430	144	V	F	Gtc/Ttc	4.58	1	0.01	benign	0.11	neutral	0.54	neutral	2.25	deleterious	-4.24	deleterious	-4.54	high_impact	4.74	0.71	neutral	0.5	neutral	1.99	16.13	deleterious	0.03	0.35	0.48	neutral	0.93	disease	0.65	disease	0.75	disease	5	0.37	neutral	0.72	deleterious	-2	neutral	0.33	neutral	0.1	medium_impact	0.31	medium_impact	2.95	high_impact	0.28	0.8	57.55	10.07	0.66	P	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3737	3737	T	C	MI.11647	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	431	144	V	A	gTc/gCc	7.11	1	0	possibly_damaging	0.64	neutral	0.65	neutral	2.27	deleterious	-3.66	deleterious	-3.63	medium_impact	3.1	0.7	neutral	0.57	neutral	1.73	14.60	neutral	0.08	0.35	0.37	neutral	0.65	disease	0.61	disease	0.65	disease	3	0.57	neutral	0.51	deleterious	0	NA	0.54	deleterious	-0.99	medium_impact	0.43	medium_impact	1.52	medium_impact	0.11	0.8	57.55	10.07	0.59	P	0.87	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3737	3737	T	G	MI.11648	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	431	144	V	G	gTc/gGc	7.11	1	0	probably_damaging	0.93	neutral	0.28	neutral	2.23	deleterious	-5.79	deleterious	-6.36	high_impact	4.18	0.79	neutral	0.57	neutral	2.22	17.61	deleterious	0.01	0.35	0.62	disease	0.87	disease	0.65	disease	0.71	disease	4	0.94	neutral	0.18	neutral	2	deleterious	0.76	deleterious	-1.81	low_impact	0.05	medium_impact	2.46	high_impact	0.31	0.8	57.55	10.07	0.63	P	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3737	3737	T	A	MI.11649	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	431	144	V	D	gTc/gAc	7.11	1	0	probably_damaging	0.95	neutral	0.16	neutral	2.22	deleterious	-6.38	deleterious	-6.36	high_impact	4.74	0.73	neutral	0.49	neutral	4.21	23.90	deleterious	0.01	0.35	0.73	disease	0.92	disease	0.74	disease	0.73	disease	5	0.97	neutral	0.11	neutral	2	deleterious	0.85	deleterious	-1.95	low_impact	-0.13	medium_impact	2.95	high_impact	0.14	0.8	57.55	10.07	0.71	P	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9074	9074	C	G	MI.1165	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	548	183	T	S	aCc/aGc	-0.8	0	0	benign	0.28	neutral	0.55	neutral	4.67	neutral	0.03	neutral	0.53	neutral_impact	-1.31	0.91	neutral	0.96	neutral	0.85	9.77	deleterious	0.51	0.65	0.31	neutral	0.17	neutral	0.23	neutral	0.25	neutral	5	0.35	neutral	0.64	deleterious	-6	neutral	0.35	neutral	-0.37	medium_impact	0.34	medium_impact	-2.22	low_impact	0.56	0.9	15.04	22.29	0.3	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3739	3739	A	C	MI.11650	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	433	145	T	P	Acc/Ccc	-9.43	0	0	probably_damaging	0.96	neutral	0.17	neutral	2.77	neutral	1.5	deleterious	-4.08	low_impact	1.89	0.64	neutral	0.19	damaging	3.43	23.00	deleterious	0.08	0.35	0.18	neutral	0.93	disease	0.66	disease	0.77	disease	5	0.97	neutral	0.11	neutral	-2	neutral	0.76	deleterious	-2.05	low_impact	-0.11	medium_impact	0.46	medium_impact	0.42	0.8	53.14	8.83	0.3	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3739	3739	A	T	MI.11651	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	433	145	T	S	Acc/Tcc	-9.43	0	0	benign	0.2	neutral	0.66	neutral	2.94	neutral	0.49	neutral	-1.4	low_impact	1.14	0.85	neutral	0.84	neutral	1.09	11.16	neutral	0.38	0.5	0.15	neutral	0.13	neutral	0.15	neutral	0.26	neutral	5	0.22	neutral	0.73	deleterious	-6	neutral	0.19	neutral	-0.19	medium_impact	0.44	medium_impact	-0.19	medium_impact	0.65	0.8	53.14	8.83	0.38	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3739	3739	A	G	MI.11652	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	433	145	T	A	Acc/Gcc	-9.43	0	0	benign	0.08	neutral	0.52	neutral	2.83	neutral	1.7	deleterious	-2.8	medium_impact	1.97	0.86	neutral	0.39	neutral	3.45	23.00	deleterious	0.24	0.45	0.17	neutral	0.63	disease	0.38	neutral	0.36	neutral	3	0.41	neutral	0.72	deleterious	-3	neutral	0.19	neutral	0.25	medium_impact	0.29	medium_impact	0.53	medium_impact	0.36	0.8	53.14	8.83	0.31	N	0.65	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3740	3740	C	G	MI.11653	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	434	145	T	S	aCc/aGc	3.67	0.99	0	benign	0.2	neutral	0.66	neutral	2.94	neutral	0.49	neutral	-1.4	low_impact	1.14	0.85	neutral	0.84	neutral	1.33	12.43	neutral	0.38	0.5	0.15	neutral	0.13	neutral	0.15	neutral	0.26	neutral	5	0.22	neutral	0.73	deleterious	-6	neutral	0.19	neutral	-0.19	medium_impact	0.44	medium_impact	-0.19	medium_impact	0.65	0.8	53.14	8.83	0.45	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3740	3740	C	T	MI.11654	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	434	145	T	I	aCc/aTc	3.67	0.99	0	probably_damaging	0.92	neutral	0.59	neutral	2.72	neutral	0.51	deleterious	-4.39	medium_impact	2.38	0.69	neutral	0.12	damaging	3.96	23.60	deleterious	0.14	0.4	0.19	neutral	0.86	disease	0.5	neutral	0.7	disease	4	0.91	neutral	0.34	neutral	1	deleterious	0.70	deleterious	-1.75	low_impact	0.36	medium_impact	0.89	medium_impact	0.74	0.85	53.14	8.83	0.36	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3740	3740	C	A	MI.11655	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	434	145	T	N	aCc/aAc	3.67	0.99	0	possibly_damaging	0.83	neutral	0.26	neutral	2.73	neutral	-1.79	deleterious	-2.93	medium_impact	2.67	0.64	neutral	0.14	damaging	3.59	23.20	deleterious	0.31	0.45	0.38	neutral	0.86	disease	0.39	neutral	0.71	disease	4	0.88	neutral	0.22	neutral	0	NA	0.73	deleterious	-1.4	low_impact	0.02	medium_impact	1.14	medium_impact	0.62	0.8	53.14	8.83	0.5	P	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3742	3742	C	A	MI.11656	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	436	146	L	M	Cta/Ata	-5.75	0	0	benign	0.39	neutral	0.24	neutral	2.03	deleterious	-3.5	neutral	-1.63	low_impact	1.62	0.82	neutral	0.81	neutral	2.48	19.33	deleterious	0.31	0.45	0.29	neutral	0.37	neutral	0.34	neutral	0.41	neutral	2	0.72	neutral	0.43	neutral	-6	neutral	0.30	neutral	-0.57	medium_impact	-0.01	medium_impact	0.23	medium_impact	0.58	0.8	16.98	26.75	0.42	N	0.11	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3742	3742	C	G	MI.11657	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	436	146	L	V	Cta/Gta	-5.75	0	0	possibly_damaging	0.64	neutral	0.56	neutral	2.06	deleterious	-3.16	deleterious	-2.66	high_impact	3.56	0.63	neutral	0.54	neutral	1.60	13.86	neutral	0.26	0.45	0.47	neutral	0.57	disease	0.52	disease	0.54	disease	1	0.59	neutral	0.46	neutral	1	deleterious	0.53	deleterious	-0.99	medium_impact	0.33	medium_impact	1.92	medium_impact	0.49	0.8	16.98	26.75	0.35	N	0.41	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3743	3743	T	C	MI.11658	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	437	146	L	P	cTa/cCa	-0.47	0	0	probably_damaging	0.93	neutral	0.17	neutral	1.94	deleterious	-6.77	deleterious	-6.27	high_impact	4.53	0.67	neutral	0.48	neutral	3.49	23.10	deleterious	0.03	0.35	0.91	disease	0.83	disease	0.71	disease	0.68	disease	4	0.96	neutral	0.12	neutral	2	deleterious	0.86	deleterious	-1.81	low_impact	-0.11	medium_impact	2.77	high_impact	0.28	0.8	16.98	26.75	0.46	N	0.87	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3743	3743	T	G	MI.11659	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	437	146	L	R	cTa/cGa	-0.47	0	0	probably_damaging	0.9	neutral	0.29	neutral	1.95	deleterious	-6.22	deleterious	-5.37	high_impact	4.53	0.68	neutral	0.44	neutral	2.55	19.79	deleterious	0.03	0.35	0.89	disease	0.86	disease	0.71	disease	0.68	disease	4	0.92	neutral	0.2	neutral	2	deleterious	0.84	deleterious	-1.65	low_impact	0.06	medium_impact	2.77	high_impact	0.14	0.8	16.98	26.75	0.48	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9076	9076	A	T	MI.1166	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	550	184	I	F	Att/Ttt	-16.07	0	0	benign	0.35	neutral	0.67	neutral	4.57	neutral	-1.52	deleterious	-2.5	low_impact	1.44	0.88	neutral	0.39	neutral	2.40	18.83	deleterious	0.55	0.65	0.67	disease	0.59	disease	0.53	disease	0.53	disease	1	0.28	neutral	0.66	deleterious	-6	neutral	0.36	neutral	-0.5	medium_impact	0.47	medium_impact	0.14	medium_impact	0.58	0.9	13.72	9.63	0.23	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3743	3743	T	A	MI.11660	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	437	146	L	Q	cTa/cAa	-0.47	0	0	probably_damaging	0.93	neutral	0.33	neutral	1.95	deleterious	-6.15	deleterious	-5.33	high_impact	4.53	0.67	neutral	0.48	neutral	3.73	23.30	deleterious	0.05	0.35	0.88	disease	0.78	disease	0.59	disease	0.69	disease	4	0.94	neutral	0.2	neutral	2	deleterious	0.80	deleterious	-1.81	low_impact	0.1	medium_impact	2.77	high_impact	0.29	0.8	16.98	26.75	0.47	N	0.86	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3745	3745	G	C	MI.11661	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	439	147	A	P	Gcc/Ccc	-0.24	0.57	0	probably_damaging	0.93	neutral	0.21	neutral	2.46	deleterious	-3.69	deleterious	-2.77	medium_impact	3.38	0.67	neutral	0.31	neutral	3.78	23.40	deleterious	0.05	0.35	0.52	disease	0.92	disease	0.69	disease	0.76	disease	5	0.95	neutral	0.14	neutral	1	deleterious	0.82	deleterious	-1.81	low_impact	-0.05	medium_impact	1.76	medium_impact	0.59	0.8	39.94	9.35	0.34	N	0.94	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3745	3745	G	A	MI.11662	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	439	147	A	T	Gcc/Acc	-0.24	0.57	0	benign	0.05	neutral	0.4	neutral	2.55	neutral	-1.79	neutral	-2.42	low_impact	1.7	0.77	neutral	0.68	neutral	4.14	23.80	deleterious	0.21	0.45	0.21	neutral	0.65	disease	0.49	neutral	0.44	neutral	1	0.56	neutral	0.68	deleterious	-6	neutral	0.19	neutral	0.45	medium_impact	0.18	medium_impact	0.3	medium_impact	0.78	0.85	39.94	9.35	0.28	N	0.51	polymorphism	1	0.11	.	.	.	.	.	.	.	.	2.37	G3745A	LHON / high altitude variant	.	.	Reported / Population-dependent	2	.	P	P	neutral
chrM	3745	3745	G	T	MI.11663	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	439	147	A	S	Gcc/Tcc	-0.24	0.57	0	benign	0.13	neutral	0.43	neutral	2.65	neutral	-0.88	neutral	-0.93	low_impact	1.55	0.73	neutral	0.56	neutral	3.65	23.20	deleterious	0.31	0.45	0.23	neutral	0.69	disease	0.34	neutral	0.23	neutral	6	0.5	neutral	0.65	deleterious	-6	neutral	0.24	neutral	0.02	medium_impact	0.21	medium_impact	0.17	medium_impact	0.53	0.8	39.94	9.35	0.34	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3746	3746	C	G	MI.11664	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	440	147	A	G	gCc/gGc	5.04	1	0	possibly_damaging	0.64	neutral	0.33	neutral	2.73	neutral	-0.36	neutral	2.32	neutral_impact	0.12	0.73	neutral	0.59	neutral	1.20	11.75	neutral	0.3	0.45	0.14	neutral	0.14	neutral	0.26	neutral	0.22	neutral	6	0.72	neutral	0.35	neutral	-3	neutral	0.44	deleterious	-0.99	medium_impact	0.1	medium_impact	-1.08	low_impact	0.68	0.85	39.94	9.35	0.65	P	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3746	3746	C	T	MI.11665	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	440	147	A	V	gCc/gTc	5.04	1	0	benign	0.08	neutral	0.51	neutral	2.49	neutral	-2.96	deleterious	-3.05	medium_impact	2.12	0.76	neutral	0.57	neutral	4.38	24.10	deleterious	0.21	0.45	0.17	neutral	0.77	disease	0.48	neutral	0.29	neutral	4	0.42	neutral	0.72	deleterious	-3	neutral	0.22	neutral	0.25	medium_impact	0.29	medium_impact	0.66	medium_impact	0.69	0.85	39.94	9.35	0.55	P	0.60	polymorphism	1	0.11	rs199684756	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3746	3746	C	A	MI.11666	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	440	147	A	D	gCc/gAc	5.04	1	0	possibly_damaging	0.83	neutral	0.21	neutral	2.47	deleterious	-3.42	neutral	-2.48	high_impact	3.92	0.73	neutral	0.38	neutral	4.59	24.40	deleterious	0.04	0.35	0.49	neutral	0.92	disease	0.68	disease	0.75	disease	5	0.9	neutral	0.19	neutral	1	deleterious	0.75	deleterious	-1.4	low_impact	-0.05	medium_impact	2.24	high_impact	0.41	0.8	39.94	9.35	0.68	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3748	3748	A	T	MI.11667	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	442	148	I	F	Atc/Ttc	-13.57	0	0	possibly_damaging	0.83	neutral	0.65	neutral	2.67	neutral	-1.49	deleterious	-2.7	low_impact	1.47	0.85	neutral	0.14	damaging	2.00	16.22	deleterious	0.17	0.45	0.27	neutral	0.73	disease	0.48	neutral	0.3	neutral	4	0.8	neutral	0.41	neutral	-3	neutral	0.64	deleterious	-1.4	low_impact	0.43	medium_impact	0.1	medium_impact	0.46	0.8	59.43	8.86	0.22	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3748	3748	A	C	MI.11668	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	442	148	I	L	Atc/Ctc	-13.57	0	0	benign	0.05	neutral	0.65	neutral	3.31	neutral	1.98	neutral	0	neutral_impact	-0.66	0.87	neutral	0.75	neutral	-0.85	0.03	neutral	0.19	0.45	0.15	neutral	0.18	neutral	0.23	neutral	0.32	neutral	4	0.28	neutral	0.8	deleterious	-6	neutral	0.10	neutral	0.45	medium_impact	0.43	medium_impact	-1.76	low_impact	0.39	0.8	59.43	8.86	0.37	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3748	3748	A	G	MI.11669	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	442	148	I	V	Atc/Gtc	-13.57	0	0	possibly_damaging	0.52	neutral	0.55	neutral	2.75	neutral	-0.47	neutral	-0.87	medium_impact	2.43	0.76	neutral	0.15	damaging	1.06	10.99	neutral	0.31	0.5	0.17	neutral	0.38	neutral	0.53	disease	0.45	neutral	1	0.49	neutral	0.52	deleterious	0	NA	0.30	neutral	-0.78	medium_impact	0.32	medium_impact	0.93	medium_impact	0.33	0.8	59.43	8.86	0.28	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9076	9076	A	C	MI.1167	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	550	184	I	L	Att/Ctt	-16.07	0	0	benign	0.03	neutral	1	neutral	4.73	neutral	0.24	neutral	-0.78	neutral_impact	0.09	0.76	neutral	0.67	neutral	0.33	5.98	deleterious	0.45	0.65	0.25	neutral	0.22	neutral	0.27	neutral	0.36	neutral	3	0.03	neutral	0.99	deleterious	-6	neutral	0.12	neutral	0.68	medium_impact	1.98	high_impact	-1.02	low_impact	0.56	0.9	13.72	9.63	0.32	N	0.72	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3749	3749	T	C	MI.11670	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	443	148	I	T	aTc/aCc	1.37	0.71	0	possibly_damaging	0.86	neutral	0.37	neutral	2.63	neutral	-2.31	deleterious	-3.55	medium_impact	2.25	0.87	neutral	0.53	neutral	1.54	13.53	neutral	0.12	0.4	0.36	neutral	0.51	disease	0.49	neutral	0.49	neutral	0	0.86	neutral	0.26	neutral	0	NA	0.65	deleterious	-1.49	low_impact	0.15	medium_impact	0.78	medium_impact	0.33	0.8	59.43	8.86	0.38	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3749	3749	T	G	MI.11671	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	443	148	I	S	aTc/aGc	1.37	0.71	0	probably_damaging	0.93	neutral	0.56	neutral	2.62	neutral	-2.79	deleterious	-4.48	medium_impact	2.43	0.72	neutral	0.12	damaging	2.51	19.55	deleterious	0.06	0.35	0.36	neutral	0.78	disease	0.56	disease	0.7	disease	4	0.92	neutral	0.32	neutral	1	deleterious	0.71	deleterious	-1.81	low_impact	0.33	medium_impact	0.93	medium_impact	0.24	0.8	59.43	8.86	0.23	N	0.94	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3749	3749	T	A	MI.11672	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	443	148	I	N	aTc/aAc	1.37	0.71	0	probably_damaging	0.96	neutral	0.24	neutral	2.6	deleterious	-3.79	deleterious	-5.4	high_impact	3.63	0.69	neutral	0.13	damaging	4.01	23.60	deleterious	0.13	0.4	0.6	disease	0.8	disease	0.58	disease	0.71	disease	4	0.97	neutral	0.14	neutral	2	deleterious	0.77	deleterious	-2.05	low_impact	-0.01	medium_impact	1.98	medium_impact	0.27	0.8	59.43	8.86	0.36	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3750	3750	C	G	MI.11673	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	444	148	I	M	atC/atG	5.5	0.95	0	possibly_damaging	0.87	neutral	0.27	neutral	2.66	neutral	-1.7	neutral	-1.34	low_impact	1.4	0.89	neutral	0.21	damaging	1.45	13.03	neutral	0.28	0.45	0.28	neutral	0.53	disease	0.46	neutral	0.36	neutral	3	0.9	neutral	0.2	neutral	-3	neutral	0.62	deleterious	-1.53	low_impact	0.03	medium_impact	0.03	medium_impact	0.51	0.8	59.43	8.86	0.55	P	0.78	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3750	3750	C	A	MI.11674	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	444	148	I	M	atC/atA	5.5	0.95	0	possibly_damaging	0.87	neutral	0.27	neutral	2.66	neutral	-1.7	neutral	-1.34	low_impact	1.4	0.89	neutral	0.21	damaging	1.97	16.03	deleterious	0.28	0.45	0.28	neutral	0.53	disease	0.46	neutral	0.36	neutral	3	0.9	neutral	0.2	neutral	-3	neutral	0.62	deleterious	-1.53	low_impact	0.03	medium_impact	0.03	medium_impact	0.51	0.8	59.43	8.86	0.55	P	0.78	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3751	3751	A	T	MI.11675	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	445	149	I	F	Att/Ttt	-5.98	0	0	probably_damaging	1	neutral	0.7	neutral	2.59	neutral	-1.59	deleterious	-3.65	medium_impact	3.29	0.68	neutral	0.14	damaging	3.71	23.30	deleterious	0.15	0.4	0.37	neutral	0.83	disease	0.58	disease	0.66	disease	3	1	deleterious	0.35	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.48	medium_impact	1.69	medium_impact	0.40	0.8	59.12	10.46	0.28	N	0.95	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3751	3751	A	G	MI.11676	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	445	149	I	V	Att/Gtt	-5.98	0	0	probably_damaging	1	neutral	0.5	neutral	2.68	neutral	0.79	neutral	-0.91	medium_impact	2.67	0.66	neutral	0.16	damaging	3.00	22.20	deleterious	0.39	0.5	0.18	neutral	0.47	neutral	0.53	disease	0.35	neutral	3	1	deleterious	0.25	neutral	1	deleterious	0.67	deleterious	-3.57	low_impact	0.28	medium_impact	1.14	medium_impact	0.48	0.8	59.12	10.46	0.33	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3751	3751	A	C	MI.11677	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	445	149	I	L	Att/Ctt	-5.98	0	0	probably_damaging	1	neutral	0.65	neutral	2.69	neutral	0	neutral	-1.82	medium_impact	2.72	0.69	neutral	0.12	damaging	3.72	23.30	deleterious	0.19	0.45	0.15	neutral	0.72	disease	0.5	neutral	0.22	neutral	6	1	deleterious	0.33	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.43	medium_impact	1.19	medium_impact	0.38	0.8	59.12	10.46	0.24	N	0.82	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3752	3752	T	C	MI.11678	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	446	149	I	T	aTt/aCt	6.65	1	0	probably_damaging	1	neutral	0.39	neutral	2.62	neutral	-0.51	deleterious	-4.55	medium_impact	3.15	0.66	neutral	0.13	damaging	3.31	22.90	deleterious	0.11	0.4	0.24	neutral	0.72	disease	0.56	disease	0.51	disease	0	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.17	medium_impact	1.56	medium_impact	0.37	0.8	59.12	10.46	0.55	P	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3752	3752	T	A	MI.11679	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	446	149	I	N	aTt/aAt	6.65	1	0	probably_damaging	1	neutral	0.31	neutral	2.57	neutral	-2.48	deleterious	-6.37	high_impact	4.64	0.73	neutral	0.15	damaging	4.40	24.10	deleterious	0.15	0.4	0.52	disease	0.84	disease	0.63	disease	0.68	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.08	medium_impact	2.86	high_impact	0.22	0.8	59.12	10.46	0.68	P	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9076	9076	A	G	MI.1168	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	550	184	I	V	Att/Gtt	-16.07	0	0	benign	0.03	neutral	0.51	neutral	4.67	neutral	-0.08	neutral	-0.59	low_impact	1.38	0.9	neutral	0.63	neutral	0.17	4.33	deleterious	0.7	0.75	0.49	neutral	0.2	neutral	0.37	neutral	0.33	neutral	3	0.46	neutral	0.74	deleterious	-6	neutral	0.15	neutral	0.68	medium_impact	0.3	medium_impact	0.09	medium_impact	0.51	0.9	13.72	9.63	0.37	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3752	3752	T	G	MI.11680	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	446	149	I	S	aTt/aGt	6.65	1	0	probably_damaging	1	neutral	0.41	neutral	2.66	neutral	1.12	deleterious	-5.45	medium_impact	2.37	0.73	neutral	0.18	damaging	4.25	23.90	deleterious	0.07	0.35	0.17	neutral	0.87	disease	0.6	disease	0.68	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.19	medium_impact	0.88	medium_impact	0.25	0.8	59.12	10.46	0.49	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3753	3753	T	G	MI.11681	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	447	149	I	M	atT/atG	7.34	1	0.01	probably_damaging	1	neutral	0.22	neutral	2.59	neutral	-1.53	deleterious	-2.73	medium_impact	2.85	0.73	neutral	0.15	damaging	3.37	22.90	deleterious	0.34	0.5	0.37	neutral	0.73	disease	0.54	disease	0.62	disease	2	1	deleterious	0.11	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	-0.03	medium_impact	1.3	medium_impact	0.56	0.8	59.12	10.46	0.6	P	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3753	3753	T	A	MI.11682	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	447	149	I	M	atT/atA	7.34	1	0.01	probably_damaging	1	neutral	0.22	neutral	2.59	neutral	-1.53	deleterious	-2.73	medium_impact	2.85	0.73	neutral	0.15	damaging	3.72	23.30	deleterious	0.34	0.5	0.37	neutral	0.73	disease	0.54	disease	0.62	disease	2	1	deleterious	0.11	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	-0.03	medium_impact	1.3	medium_impact	0.56	0.8	59.12	10.46	0.6	P	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3754	3754	C	A	MI.11683	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	448	150	L	M	Cta/Ata	-4.84	0	0	possibly_damaging	0.52	neutral	0.31	neutral	2.25	deleterious	-3.57	neutral	-1.57	medium_impact	2.2	0.71	neutral	0.68	neutral	3.67	23.30	deleterious	0.24	0.45	0.37	neutral	0.38	neutral	0.36	neutral	0.44	neutral	1	0.67	neutral	0.4	neutral	0	NA	0.35	neutral	-0.78	medium_impact	0.08	medium_impact	0.73	medium_impact	0.45	0.8	17.92	14.15	0.42	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3754	3754	C	G	MI.11684	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	448	150	L	V	Cta/Gta	-4.84	0	0	benign	0.12	neutral	0.66	neutral	2.53	neutral	-0.99	neutral	-1.98	low_impact	1.72	0.84	neutral	0.75	neutral	3.32	22.90	deleterious	0.22	0.45	0.15	neutral	0.47	neutral	0.36	neutral	0.38	neutral	2	0.23	neutral	0.77	deleterious	-6	neutral	0.17	neutral	0.06	medium_impact	0.44	medium_impact	0.31	medium_impact	0.42	0.8	17.92	14.15	0.27	N	0.59	polymorphism	1	0.04	rs28615151	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3755	3755	T	C	MI.11685	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	449	150	L	P	cTa/cCa	-0.47	0	0	probably_damaging	0.98	neutral	0.1	neutral	2.2	deleterious	-6.11	deleterious	-5.75	high_impact	3.92	0.7	neutral	0.46	neutral	3.79	23.40	deleterious	0.03	0.35	0.72	disease	0.82	disease	0.71	disease	0.72	disease	4	0.99	deleterious	0.06	neutral	2	deleterious	0.85	deleterious	-2.34	low_impact	-0.26	medium_impact	2.24	high_impact	0.34	0.8	17.92	14.15	0.39	N	0.93	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3755	3755	T	A	MI.11686	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	449	150	L	Q	cTa/cAa	-0.47	0	0	probably_damaging	0.96	neutral	0.14	neutral	2.2	deleterious	-5.59	deleterious	-5.11	high_impact	4.28	0.72	neutral	0.5	neutral	3.96	23.60	deleterious	0.04	0.35	0.66	disease	0.73	disease	0.59	disease	0.65	disease	3	0.98	neutral	0.09	neutral	2	deleterious	0.77	deleterious	-2.05	low_impact	-0.17	medium_impact	2.55	high_impact	0.31	0.8	17.92	14.15	0.46	N	0.93	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3755	3755	T	G	MI.11687	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	449	150	L	R	cTa/cGa	-0.47	0	0	probably_damaging	0.96	neutral	0.17	neutral	2.2	deleterious	-5.57	deleterious	-5.17	high_impact	4.28	0.69	neutral	0.45	neutral	4.04	23.70	deleterious	0.03	0.35	0.64	disease	0.84	disease	0.7	disease	0.73	disease	5	0.97	neutral	0.11	neutral	2	deleterious	0.82	deleterious	-2.05	low_impact	-0.11	medium_impact	2.55	high_impact	0.15	0.8	17.92	14.15	0.44	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3757	3757	C	A	MI.11688	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	451	151	L	M	Cta/Ata	-20	0	0	probably_damaging	0.98	neutral	0.2	neutral	2.24	deleterious	-3.08	neutral	-1.75	low_impact	1.65	0.81	neutral	0.18	damaging	3.72	23.30	deleterious	0.25	0.45	0.41	neutral	0.4	neutral	0.34	neutral	0.44	neutral	1	0.99	deleterious	0.11	neutral	-2	neutral	0.69	deleterious	-2.34	low_impact	-0.06	medium_impact	0.25	medium_impact	0.49	0.8	60.06	10.09	0.33	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3757	3757	C	G	MI.11689	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	451	151	L	V	Cta/Gta	-20	0	0	benign	0.3	neutral	0.56	neutral	2.32	neutral	-2.21	deleterious	-2.57	medium_impact	2.58	0.8	neutral	0.2	damaging	3.39	23.00	deleterious	0.21	0.45	0.28	neutral	0.56	disease	0.49	neutral	0.21	neutral	6	0.34	neutral	0.63	deleterious	-3	neutral	0.27	neutral	-0.41	medium_impact	0.33	medium_impact	1.07	medium_impact	0.42	0.8	60.06	10.09	0.22	N	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9077	9077	T	C	MI.1169	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	551	184	I	T	aTt/aCt	2.21	0.55	0	benign	0	neutral	0.59	neutral	4.55	neutral	-1.74	deleterious	-2.65	neutral_impact	0.2	0.96	neutral	0.85	neutral	0.20	4.65	deleterious	0.48	0.65	0.62	disease	0.29	neutral	0.33	neutral	0.58	disease	1	0.4	neutral	0.8	deleterious	-6	neutral	0.18	neutral	2.09	high_impact	0.38	medium_impact	-0.93	medium_impact	0.49	0.9	13.72	9.63	0.26	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3758	3758	T	C	MI.11690	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	452	151	L	P	cTa/cCa	-0.7	0	0	probably_damaging	1	neutral	0.12	neutral	2.16	deleterious	-5.79	deleterious	-6.15	high_impact	4.6	0.77	neutral	0.14	damaging	3.96	23.60	deleterious	0.06	0.35	0.72	disease	0.84	disease	0.72	disease	0.7	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.21	medium_impact	2.83	high_impact	0.30	0.8	60.06	10.09	0.44	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3758	3758	T	G	MI.11691	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	452	151	L	R	cTa/cGa	-0.7	0	0	probably_damaging	0.99	neutral	0.18	neutral	2.18	deleterious	-4.53	deleterious	-5.31	high_impact	4.6	0.75	neutral	0.11	damaging	4.11	23.70	deleterious	0.05	0.35	0.64	disease	0.88	disease	0.71	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-2.62	low_impact	-0.09	medium_impact	2.83	high_impact	0.13	0.8	60.06	10.09	0.46	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3758	3758	T	A	MI.11692	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	452	151	L	Q	cTa/cAa	-0.7	0	0	probably_damaging	1	neutral	0.18	neutral	2.17	deleterious	-5.08	deleterious	-5.28	high_impact	4.6	0.73	neutral	0.12	damaging	4.22	23.90	deleterious	0.07	0.35	0.66	disease	0.78	disease	0.59	disease	0.65	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	-0.09	medium_impact	2.83	high_impact	0.26	0.8	60.06	10.09	0.44	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3760	3760	T	C	MI.11693	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	454	152	S	P	Tca/Cca	-1.85	0	0	probably_damaging	0.91	neutral	0.11	neutral	2.44	deleterious	-3.81	deleterious	-3.72	medium_impact	2.7	0.82	neutral	0.47	neutral	3.91	23.50	deleterious	0.05	0.35	0.61	disease	0.89	disease	0.6	disease	0.54	disease	1	0.96	neutral	0.1	neutral	1	deleterious	0.81	deleterious	-1.69	low_impact	-0.23	medium_impact	1.17	medium_impact	0.31	0.8	55.03	9.31	0.34	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3760	3760	T	G	MI.11694	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	454	152	S	A	Tca/Gca	-1.85	0	0	benign	0.05	neutral	0.32	neutral	2.67	neutral	-0.66	neutral	-1.69	medium_impact	2.06	0.9	neutral	0.62	neutral	2.47	19.27	deleterious	0.31	0.45	0.23	neutral	0.52	disease	0.34	neutral	0.19	neutral	6	0.65	neutral	0.64	deleterious	-3	neutral	0.19	neutral	0.45	medium_impact	0.09	medium_impact	0.61	medium_impact	0.46	0.8	55.03	9.31	0.44	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3760	3760	T	A	MI.11695	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	454	152	S	T	Tca/Aca	-1.85	0	0	possibly_damaging	0.64	neutral	0.3	neutral	2.52	neutral	-1.93	neutral	-1.84	low_impact	1.82	0.79	neutral	0.53	neutral	3.61	23.20	deleterious	0.31	0.5	0.25	neutral	0.56	disease	0.34	neutral	0.18	neutral	6	0.74	neutral	0.33	neutral	-3	neutral	0.55	deleterious	-0.99	medium_impact	0.07	medium_impact	0.4	medium_impact	0.57	0.8	55.03	9.31	0.37	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3761	3761	C	G	MI.11696	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	455	152	S	W	tCa/tGa	1.14	0	0	probably_damaging	0.98	neutral	0.09	neutral	2.41	deleterious	-6.43	deleterious	-4.99	high_impact	4.15	0.67	neutral	0.39	neutral	4.26	23.90	deleterious	0.06	0.35	0.81	disease	0.91	disease	0.59	disease	0.68	disease	4	0.99	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-2.34	low_impact	-0.29	medium_impact	2.44	high_impact	0.14	0.8	55.03	9.31	0.41	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3761	3761	C	T	MI.11697	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	455	152	S	L	tCa/tTa	1.14	0	0	possibly_damaging	0.64	neutral	1	neutral	2.46	deleterious	-3.09	deleterious	-4.12	medium_impact	2.33	0.7	neutral	0.34	neutral	4.57	24.40	deleterious	0.1	0.4	0.32	neutral	0.87	disease	0.51	disease	0.68	disease	4	0.64	neutral	0.68	deleterious	0	NA	0.54	deleterious	-0.99	medium_impact	1.96	high_impact	0.85	medium_impact	0.35	0.8	55.03	9.31	0.29	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3763	3763	A	G	MI.11698	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	457	153	T	A	Aca/Gca	-5.07	0	0	benign	0.12	neutral	0.23	neutral	2.8	neutral	-0.12	neutral	-0.88	neutral_impact	0.32	0.83	neutral	0.77	neutral	0.26	5.25	deleterious	0.25	0.45	0.15	neutral	0.24	neutral	0.34	neutral	0.4	neutral	2	0.74	neutral	0.56	deleterious	-6	neutral	0.10	neutral	0.06	medium_impact	-0.02	medium_impact	-0.91	medium_impact	0.36	0.8	22.64	17.03	0.4	N	0.28	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3763	3763	A	T	MI.11699	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	457	153	T	S	Aca/Tca	-5.07	0	0	benign	0.3	neutral	0.21	neutral	2.77	neutral	-1.04	neutral	-1.39	neutral_impact	0.18	0.83	neutral	0.81	neutral	1.47	13.14	neutral	0.36	0.5	0.26	neutral	0.34	neutral	0.34	neutral	0.43	neutral	1	0.75	neutral	0.46	neutral	-6	neutral	0.19	neutral	-0.41	medium_impact	-0.05	medium_impact	-1.03	low_impact	0.51	0.8	22.64	17.03	0.41	N	0.24	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8581	8581	G	A	MI.117	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	55	19	A	T	Gcc/Acc	-4.73	0	0	probably_damaging	1	neutral	0.06	neutral	4.66	neutral	-0.45	neutral	-0.45	neutral_impact	-0.4	0.93	neutral	0.86	neutral	2.81	21.40	deleterious	0.39	0.65	0.27	neutral	0.28	neutral	0.22	neutral	0.44	neutral	1	1	deleterious	0.03	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	-0.38	medium_impact	-1.44	low_impact	0.61	0.9	29.65	29.28	0.49	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9077	9077	T	G	MI.1170	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	551	184	I	S	aTt/aGt	2.21	0.55	0	benign	0.07	neutral	0.6	neutral	4.55	neutral	-1.9	deleterious	-3.36	neutral_impact	0.28	0.8	neutral	0.64	neutral	1.29	12.23	neutral	0.39	0.65	0.41	neutral	0.59	disease	0.36	neutral	0.46	neutral	1	0.33	neutral	0.77	deleterious	-6	neutral	0.19	neutral	0.31	medium_impact	0.39	medium_impact	-0.86	medium_impact	0.52	0.9	13.72	9.63	0.24	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3763	3763	A	C	MI.11700	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	457	153	T	P	Aca/Cca	-5.07	0	0	possibly_damaging	0.71	neutral	0.07	neutral	2.74	neutral	-2.47	deleterious	-2.56	neutral_impact	0.64	0.64	neutral	0.45	neutral	1.82	15.10	deleterious	0.09	0.35	0.37	neutral	0.79	disease	0.62	disease	0.65	disease	3	0.94	neutral	0.18	neutral	-3	neutral	0.52	deleterious	-1.12	low_impact	-0.35	medium_impact	-0.63	medium_impact	0.36	0.8	22.64	17.03	0.32	N	0.35	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3764	3764	C	A	MI.11701	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	458	153	T	K	aCa/aAa	-3	0	0	benign	0.41	neutral	0.07	neutral	2.75	neutral	-1.71	neutral	-2.28	medium_impact	2.17	0.68	neutral	0.52	neutral	2.71	20.90	deleterious	0.11	0.4	0.37	neutral	0.69	disease	0.59	disease	0.69	disease	4	0.92	neutral	0.33	neutral	-3	neutral	0.35	neutral	-0.6	medium_impact	-0.35	medium_impact	0.71	medium_impact	0.41	0.8	22.64	17.03	0.39	N	0.41	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3764	3764	C	T	MI.11702	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	458	153	T	M	aCa/aTa	-3	0	0	possibly_damaging	0.5	neutral	0.16	neutral	2.79	neutral	-0.26	neutral	0.28	neutral_impact	0.32	0.83	neutral	0.81	neutral	0.87	9.90	deleterious	0.14	0.4	0.2	neutral	0.33	neutral	0.25	neutral	0.44	neutral	1	0.82	neutral	0.33	neutral	-3	neutral	0.31	neutral	-0.75	medium_impact	-0.13	medium_impact	-0.91	medium_impact	0.48	0.8	22.64	17.03	0.45	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3766	3766	T	A	MI.11703	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	460	154	L	M	Tta/Ata	-13.34	0	0	probably_damaging	0.98	neutral	0.12	neutral	2.65	neutral	-1.89	neutral	-0.85	neutral_impact	0.74	0.88	neutral	0.85	neutral	2.38	18.69	deleterious	0.32	0.5	0.41	neutral	0.32	neutral	0.42	neutral	0.46	neutral	1	0.99	deleterious	0.07	neutral	-2	neutral	0.65	deleterious	-2.34	low_impact	-0.21	medium_impact	-0.54	medium_impact	0.57	0.8	22.01	23.66	0.45	N	0.17	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3766	3766	T	G	MI.11704	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	460	154	L	V	Tta/Gta	-13.34	0	0	possibly_damaging	0.76	neutral	0.17	neutral	2.92	neutral	0.66	neutral	0.23	neutral_impact	0.06	0.87	neutral	0.64	neutral	1.83	15.18	deleterious	0.28	0.45	0.17	neutral	0.16	neutral	0.23	neutral	0.27	neutral	5	0.88	neutral	0.21	neutral	-3	neutral	0.48	deleterious	-1.22	low_impact	-0.11	medium_impact	-1.14	low_impact	0.63	0.8	22.01	23.66	0.44	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3767	3767	T	G	MI.11705	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	461	154	L	W	tTa/tGa	-0.7	0	0	probably_damaging	1	deleterious	0.04	neutral	2.59	deleterious	-4.71	deleterious	-4.51	medium_impact	3.41	0.69	neutral	0.1	damaging	3.71	23.30	deleterious	0.07	0.35	0.74	disease	0.68	disease	0.58	disease	0.69	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-3.57	low_impact	-0.5	medium_impact	1.79	medium_impact	0.24	0.8	22.01	23.66	0.34	N	0.95	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3767	3767	T	C	MI.11706	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	461	154	L	S	tTa/tCa	-0.7	0	0	probably_damaging	0.99	neutral	0.23	neutral	2.65	neutral	-1.81	deleterious	-3.76	medium_impact	1.97	0.74	neutral	0.15	damaging	3.77	23.40	deleterious	0.09	0.35	0.33	neutral	0.56	disease	0.55	disease	0.66	disease	3	0.99	deleterious	0.12	neutral	1	deleterious	0.69	deleterious	-2.62	low_impact	-0.02	medium_impact	0.53	medium_impact	0.26	0.8	22.01	23.66	0.32	N	0.90	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3768	3768	A	T	MI.11707	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	462	154	L	F	ttA/ttT	4.35	0.6	0	probably_damaging	0.98	neutral	0.16	neutral	2.63	neutral	-2.28	neutral	-2.19	low_impact	1.66	0.8	neutral	0.13	damaging	3.56	23.10	deleterious	0.29	0.45	0.27	neutral	0.55	disease	0.45	neutral	0.42	neutral	2	0.99	deleterious	0.09	neutral	-2	neutral	0.65	deleterious	-2.34	low_impact	-0.13	medium_impact	0.26	medium_impact	0.64	0.8	22.01	23.66	0.38	N	0.65	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3768	3768	A	C	MI.11708	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	462	154	L	F	ttA/ttC	4.35	0.6	0	probably_damaging	0.98	neutral	0.16	neutral	2.63	neutral	-2.28	neutral	-2.19	low_impact	1.66	0.8	neutral	0.13	damaging	3.42	23.00	deleterious	0.29	0.45	0.27	neutral	0.55	disease	0.45	neutral	0.42	neutral	2	0.99	deleterious	0.09	neutral	-2	neutral	0.65	deleterious	-2.34	low_impact	-0.13	medium_impact	0.26	medium_impact	0.64	0.8	22.01	23.66	0.36	N	0.65	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3769	3769	C	G	MI.11709	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	463	155	L	V	Cta/Gta	-3.23	0	0	possibly_damaging	0.9	neutral	0.23	neutral	2.63	neutral	-1.04	neutral	-0.91	low_impact	1.42	0.8	neutral	0.26	damaging	2.14	17.09	deleterious	0.4	0.5	0.23	neutral	0.29	neutral	0.28	neutral	0.43	neutral	1	0.93	neutral	0.17	neutral	-3	neutral	0.58	deleterious	-1.65	low_impact	-0.02	medium_impact	0.05	medium_impact	0.53	0.8	58.81	9.4	0.37	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	C3769G	LHON	+	-	Reported	1	.	P	P	neutral
chrM	9077	9077	T	A	MI.1171	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	551	184	I	N	aTt/aAt	2.21	0.55	0	benign	0.17	neutral	0.42	neutral	4.5	deleterious	-3.27	deleterious	-4.4	low_impact	1.44	0.88	neutral	0.48	neutral	2.59	20.10	deleterious	0.44	0.65	0.81	disease	0.65	disease	0.41	neutral	0.56	disease	1	0.5	neutral	0.63	deleterious	-6	neutral	0.40	neutral	-0.1	medium_impact	0.21	medium_impact	0.14	medium_impact	0.59	0.9	13.72	9.63	0.31	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3769	3769	C	A	MI.11710	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	463	155	L	M	Cta/Ata	-3.23	0	0	possibly_damaging	0.76	neutral	0.18	neutral	2.6	neutral	-1.37	neutral	-0.8	low_impact	0.9	0.88	neutral	0.84	neutral	2.39	18.75	deleterious	0.26	0.45	0.23	neutral	0.25	neutral	0.27	neutral	0.43	neutral	1	0.88	neutral	0.21	neutral	-3	neutral	0.53	deleterious	-1.22	low_impact	-0.09	medium_impact	-0.4	medium_impact	0.49	0.8	58.81	9.4	0.47	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3770	3770	T	C	MI.11711	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	464	155	L	P	cTa/cCa	-2.31	0	0	probably_damaging	1	neutral	0.08	neutral	2.46	deleterious	-4.65	deleterious	-5.18	medium_impact	3.4	0.8	neutral	0.08	damaging	3.91	23.50	deleterious	0.02	0.35	0.61	disease	0.84	disease	0.7	disease	0.73	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.82	deleterious	-3.57	low_impact	-0.32	medium_impact	1.78	medium_impact	0.21	0.8	58.81	9.4	0.27	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3770	3770	T	G	MI.11712	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	464	155	L	R	cTa/cGa	-2.31	0	0	probably_damaging	0.98	deleterious	0.03	neutral	2.47	deleterious	-4.05	deleterious	-4.68	high_impact	3.96	0.71	neutral	0.07	damaging	4.13	23.80	deleterious	0.02	0.35	0.5	neutral	0.83	disease	0.68	disease	0.73	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-2.34	low_impact	-0.57	medium_impact	2.27	high_impact	0.13	0.8	58.81	9.4	0.31	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3770	3770	T	A	MI.11713	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	464	155	L	Q	cTa/cAa	-2.31	0	0	probably_damaging	0.99	deleterious	0.03	neutral	2.47	deleterious	-4.11	deleterious	-4.51	high_impact	3.96	0.76	neutral	0.07	damaging	4.14	23.80	deleterious	0.03	0.35	0.39	neutral	0.67	disease	0.55	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.69	deleterious	-2.62	low_impact	-0.57	medium_impact	2.27	high_impact	0.20	0.8	58.81	9.4	0.35	N	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3772	3772	A	G	MI.11714	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	466	156	M	V	Ata/Gta	-0.93	0	0	possibly_damaging	0.44	neutral	0.16	neutral	2.87	neutral	0.59	neutral	-1.21	low_impact	1.71	0.83	neutral	0.55	neutral	1.55	13.60	neutral	0.29	0.45	0.12	neutral	0.46	neutral	0.59	disease	0.48	neutral	0	0.82	neutral	0.36	neutral	-3	neutral	0.26	neutral	-0.65	medium_impact	-0.13	medium_impact	0.31	medium_impact	0.28	0.8	24.21	24.64	0.36	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3772	3772	A	T	MI.11715	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	466	156	M	L	Ata/Tta	-0.93	0	0	benign	0.33	neutral	1	neutral	2.94	neutral	0.89	neutral	0.24	neutral_impact	-0.79	0.86	neutral	0.95	neutral	0.58	8.04	deleterious	0.24	0.45	0.15	neutral	0.23	neutral	0.3	neutral	0.41	neutral	2	0.33	neutral	0.84	deleterious	-6	neutral	0.17	neutral	-0.46	medium_impact	1.96	high_impact	-1.88	low_impact	0.25	0.8	24.21	24.64	0.24	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3772	3772	A	C	MI.11716	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	466	156	M	L	Ata/Cta	-0.93	0	0	benign	0.33	neutral	1	neutral	2.94	neutral	0.89	neutral	0.24	neutral_impact	-0.79	0.86	neutral	0.95	neutral	0.48	7.28	deleterious	0.24	0.45	0.15	neutral	0.23	neutral	0.3	neutral	0.41	neutral	2	0.33	neutral	0.84	deleterious	-6	neutral	0.17	neutral	-0.46	medium_impact	1.96	high_impact	-1.88	low_impact	0.25	0.8	24.21	24.64	0.23	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3773	3773	T	A	MI.11717	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	467	156	M	K	aTa/aAa	-0.47	0	0	possibly_damaging	0.56	deleterious	0.03	neutral	2.76	neutral	-1.86	deleterious	-3.66	medium_impact	2.85	0.68	neutral	0.36	neutral	4.03	23.60	deleterious	0.04	0.35	0.4	neutral	0.72	disease	0.7	disease	0.7	disease	4	0.97	neutral	0.24	neutral	4	deleterious	0.51	deleterious	-0.85	medium_impact	-0.57	medium_impact	1.3	medium_impact	0.15	0.8	24.21	24.64	0.35	N	0.90	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3773	3773	T	C	MI.11718	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	467	156	M	T	aTa/aCa	-0.47	0	0	benign	0.04	neutral	0.07	neutral	2.79	neutral	-0.51	deleterious	-2.79	low_impact	1.69	0.82	neutral	0.75	neutral	1.85	15.30	deleterious	0.17	0.45	0.24	neutral	0.43	neutral	0.61	disease	0.47	neutral	1	0.93	neutral	0.52	deleterious	-6	neutral	0.14	neutral	0.55	medium_impact	-0.35	medium_impact	0.29	medium_impact	0.10	0.8	24.21	24.64	0.42	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3774	3774	A	T	MI.11719	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	468	156	M	I	atA/atT	2.98	0.13	0	possibly_damaging	0.44	neutral	0.61	neutral	2.84	neutral	0.06	neutral	-0.47	neutral_impact	0.75	0.86	neutral	0.95	neutral	1.84	15.21	deleterious	0.33	0.5	0.15	neutral	0.45	neutral	0.38	neutral	0.38	neutral	2	0.38	neutral	0.59	deleterious	-3	neutral	0.33	neutral	-0.65	medium_impact	0.38	medium_impact	-0.53	medium_impact	0.23	0.8	24.21	24.64	0.33	N	0.29	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9078	9078	T	A	MI.1172	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	552	184	I	M	atT/atA	2.44	0.57	0.01	possibly_damaging	0.54	neutral	0.52	neutral	4.57	neutral	-1.2	neutral	-1.23	neutral_impact	0.28	0.86	neutral	0.66	neutral	1.70	14.43	neutral	0.67	0.75	0.34	neutral	0.18	neutral	0.3	neutral	0.28	neutral	4	0.52	neutral	0.49	deleterious	-3	neutral	0.40	neutral	-0.82	medium_impact	0.31	medium_impact	-0.86	medium_impact	0.75	0.9	13.72	9.63	0.31	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3774	3774	A	C	MI.11720	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	468	156	M	I	atA/atC	2.98	0.13	0	possibly_damaging	0.44	neutral	0.61	neutral	2.84	neutral	0.06	neutral	-0.47	neutral_impact	0.75	0.86	neutral	0.95	neutral	1.76	14.74	neutral	0.33	0.5	0.15	neutral	0.45	neutral	0.38	neutral	0.38	neutral	2	0.38	neutral	0.59	deleterious	-3	neutral	0.33	neutral	-0.65	medium_impact	0.38	medium_impact	-0.53	medium_impact	0.23	0.8	24.21	24.64	0.33	N	0.29	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3775	3775	A	C	MI.11721	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	469	157	S	R	Agt/Cgt	-1.39	0	0	possibly_damaging	0.66	neutral	0.05	neutral	2.7	neutral	-2.29	neutral	-2.38	medium_impact	3.29	0.69	neutral	0.45	neutral	1.87	15.41	deleterious	0.06	0.35	0.36	neutral	0.78	disease	0.64	disease	0.69	disease	4	0.95	neutral	0.2	neutral	0	NA	0.62	deleterious	-1.02	low_impact	-0.44	medium_impact	1.69	medium_impact	0.40	0.8	17.61	19.73	0.45	N	0.71	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3775	3775	A	T	MI.11722	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	469	157	S	C	Agt/Tgt	-1.39	0	0	probably_damaging	0.96	neutral	0.13	neutral	2.65	deleterious	-3.65	deleterious	-2.81	medium_impact	2.43	0.82	neutral	0.51	neutral	3.05	22.40	deleterious	0.13	0.4	0.58	disease	0.65	disease	0.38	neutral	0.34	neutral	3	0.98	deleterious	0.09	neutral	1	deleterious	0.71	deleterious	-2.05	low_impact	-0.19	medium_impact	0.93	medium_impact	0.28	0.8	17.61	19.73	0.36	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3775	3775	A	G	MI.11723	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	469	157	S	G	Agt/Ggt	-1.39	0	0	benign	0.4	neutral	0.09	neutral	2.68	neutral	-2.34	neutral	-2.29	medium_impact	2.48	0.7	neutral	0.53	neutral	1.62	13.97	neutral	0.21	0.45	0.43	neutral	0.42	neutral	0.46	neutral	0.46	neutral	1	0.9	neutral	0.35	neutral	-3	neutral	0.29	neutral	-0.59	medium_impact	-0.29	medium_impact	0.98	medium_impact	0.49	0.8	17.61	19.73	0.45	N	0.28	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3776	3776	G	C	MI.11724	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	470	157	S	T	aGt/aCt	1.6	0	0	benign	0.4	neutral	0.09	neutral	2.77	neutral	0.03	neutral	0.12	neutral_impact	0.32	0.76	neutral	0.66	neutral	-0.96	0.02	neutral	0.36	0.5	0.2	neutral	0.1	neutral	0.27	neutral	0.26	neutral	5	0.9	neutral	0.35	neutral	-6	neutral	0.31	neutral	-0.59	medium_impact	-0.29	medium_impact	-0.91	medium_impact	0.60	0.8	17.61	19.73	0.5	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3776	3776	G	A	MI.11725	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	470	157	S	N	aGt/aAt	1.6	0	0	benign	0.03	neutral	0.14	neutral	2.72	neutral	-2	neutral	-0.48	low_impact	1.26	0.8	neutral	0.93	neutral	-0.52	0.20	neutral	0.54	0.6	0.26	neutral	0.35	neutral	0.39	neutral	0.43	neutral	1	0.85	neutral	0.56	deleterious	-6	neutral	0.15	neutral	0.67	medium_impact	-0.17	medium_impact	-0.09	medium_impact	0.38	0.8	17.61	19.73	0.45	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3776	3776	G	T	MI.11726	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	470	157	S	I	aGt/aTt	1.6	0	0	probably_damaging	0.92	neutral	0.48	neutral	2.74	neutral	-1.31	deleterious	-3.14	low_impact	1.27	0.72	neutral	0.5	neutral	2.38	18.67	deleterious	0.1	0.4	0.23	neutral	0.61	disease	0.34	neutral	0.21	neutral	6	0.91	neutral	0.28	neutral	-2	neutral	0.63	deleterious	-1.75	low_impact	0.26	medium_impact	-0.08	medium_impact	0.42	0.8	17.61	19.73	0.31	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3778	3778	G	A	MI.11727	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	472	158	G	S	Ggc/Agc	-8.74	0	0	probably_damaging	1	neutral	0.68	neutral	2.6	neutral	-2.31	deleterious	-5.57	medium_impact	2.68	0.34	damaging	0.03	damaging	4.16	23.80	deleterious	0.11	0.4	0.29	neutral	0.7	disease	0.51	disease	0.17	neutral	7	1	deleterious	0.34	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.46	medium_impact	1.15	medium_impact	0.40	0.8	60.06	10.42	0.42	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	COSM6716694	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3778	3778	G	T	MI.11728	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	472	158	G	C	Ggc/Tgc	-8.74	0	0	probably_damaging	1	neutral	0.22	neutral	2.5	deleterious	-6.44	deleterious	-8.37	high_impact	3.68	0.49	damaging	0.01	damaging	4.20	23.90	deleterious	0.07	0.35	0.83	disease	0.84	disease	0.65	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	-0.03	medium_impact	2.03	high_impact	0.15	0.8	60.06	10.42	0.32	N	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3778	3778	G	C	MI.11729	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	472	158	G	R	Ggc/Cgc	-8.74	0	0	probably_damaging	1	neutral	0.3	neutral	2.55	neutral	-2.73	deleterious	-7.43	medium_impact	3.34	0.5	damaging	0.01	damaging	3.97	23.60	deleterious	0.06	0.35	0.4	neutral	0.85	disease	0.8	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.82	deleterious	-3.57	low_impact	0.07	medium_impact	1.73	medium_impact	0.52	0.8	60.06	10.42	0.38	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9078	9078	T	G	MI.1173	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	552	184	I	M	atT/atG	2.44	0.57	0.01	possibly_damaging	0.54	neutral	0.52	neutral	4.57	neutral	-1.2	neutral	-1.23	neutral_impact	0.28	0.86	neutral	0.66	neutral	1.47	13.13	neutral	0.67	0.75	0.34	neutral	0.18	neutral	0.3	neutral	0.28	neutral	4	0.52	neutral	0.49	deleterious	-3	neutral	0.40	neutral	-0.82	medium_impact	0.31	medium_impact	-0.86	medium_impact	0.75	0.9	13.72	9.63	0.32	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3779	3779	G	C	MI.11730	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	473	158	G	A	gGc/gCc	5.96	1	0	probably_damaging	1	neutral	0.48	neutral	2.58	neutral	-2.54	deleterious	-5.57	high_impact	3.77	0.38	damaging	0.03	damaging	3.03	22.30	deleterious	0.12	0.4	0.36	neutral	0.55	disease	0.7	disease	0.65	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.26	medium_impact	2.1	high_impact	0.34	0.8	60.06	10.42	0.68	P	0.76	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3779	3779	G	A	MI.11731	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	473	158	G	D	gGc/gAc	5.96	1	0	probably_damaging	1	neutral	0.17	neutral	2.64	deleterious	-3.03	deleterious	-6.51	medium_impact	3.48	0.47	damaging	0.01	damaging	3.78	23.40	deleterious	0.06	0.35	0.34	neutral	0.83	disease	0.79	disease	0.58	disease	2	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	-0.11	medium_impact	1.85	medium_impact	0.17	0.8	60.06	10.42	0.64	P	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3779	3779	G	T	MI.11732	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	473	158	G	V	gGc/gTc	5.96	1	0	probably_damaging	1	neutral	0.7	neutral	2.53	deleterious	-4.03	deleterious	-8.37	high_impact	3.77	0.43	damaging	0.02	damaging	3.75	23.30	deleterious	0.06	0.35	0.53	disease	0.79	disease	0.72	disease	0.68	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.48	medium_impact	2.1	high_impact	0.15	0.8	60.06	10.42	0.62	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3781	3781	T	A	MI.11733	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	475	159	S	T	Tcc/Acc	-12.65	0	0	probably_damaging	1	neutral	0.28	neutral	2.55	neutral	-0.82	neutral	-1.95	low_impact	1.9	0.87	neutral	0.17	damaging	3.71	23.30	deleterious	0.26	0.45	0.23	neutral	0.31	neutral	0.46	neutral	0.43	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.69	deleterious	-3.57	low_impact	0.05	medium_impact	0.47	medium_impact	0.46	0.8	60.69	10.13	0.36	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3781	3781	T	G	MI.11734	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	475	159	S	A	Tcc/Gcc	-12.65	0	0	probably_damaging	1	neutral	0.33	neutral	2.59	neutral	-2.44	neutral	-1.16	medium_impact	3.4	0.81	neutral	0.15	damaging	3.63	23.20	deleterious	0.21	0.45	0.33	neutral	0.33	neutral	0.62	disease	0.48	neutral	0	1	deleterious	0.17	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.1	medium_impact	1.78	medium_impact	0.33	0.8	60.69	10.13	0.35	N	0.46	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3781	3781	T	C	MI.11735	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	475	159	S	P	Tcc/Ccc	-12.65	0	0	probably_damaging	1	neutral	0.1	neutral	2.5	deleterious	-3.33	deleterious	-2.89	high_impact	3.54	0.57	damaging	0.04	damaging	3.96	23.60	deleterious	0.06	0.35	0.53	disease	0.84	disease	0.69	disease	0.73	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.26	medium_impact	1.9	medium_impact	0.17	0.8	60.69	10.13	0.23	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	T3781C	LHON	+	-	Reported	1	.	P	P	damaging
chrM	3782	3782	C	G	MI.11736	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	476	159	S	C	tCc/tGc	2.29	0.92	0	probably_damaging	1	neutral	0.2	neutral	2.48	deleterious	-6.02	deleterious	-3.44	medium_impact	3.19	0.64	neutral	0.06	damaging	3.59	23.20	deleterious	0.08	0.35	0.74	disease	0.7	disease	0.63	disease	0.69	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	-0.06	medium_impact	1.6	medium_impact	0.28	0.8	60.69	10.13	0.39	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3782	3782	C	A	MI.11737	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	476	159	S	Y	tCc/tAc	2.29	0.92	0	probably_damaging	1	neutral	0.53	neutral	2.49	deleterious	-4.54	deleterious	-3.72	medium_impact	3.4	0.69	neutral	0.05	damaging	4.10	23.70	deleterious	0.08	0.35	0.6	disease	0.68	disease	0.72	disease	0.72	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.3	medium_impact	1.78	medium_impact	0.23	0.8	60.69	10.13	0.38	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3782	3782	C	T	MI.11738	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	476	159	S	F	tCc/tTc	2.29	0.92	0	probably_damaging	1	neutral	0.64	neutral	2.49	deleterious	-4.96	deleterious	-3.81	medium_impact	3.4	0.6	damaging	0.05	damaging	4.28	24.00	deleterious	0.1	0.4	0.46	neutral	0.74	disease	0.71	disease	0.72	disease	4	1	deleterious	0.32	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.42	medium_impact	1.78	medium_impact	0.09	0.8	60.69	10.13	0.39	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3784	3784	T	A	MI.11739	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	478	160	F	I	Ttt/Att	-7.59	0	0	probably_damaging	0.91	neutral	0.88	neutral	2.76	neutral	-1	deleterious	-5.41	medium_impact	2.9	0.72	neutral	0.53	neutral	4.39	24.10	deleterious	0.18	0.45	0.23	neutral	0.7	disease	0.66	disease	0.65	disease	3	0.9	neutral	0.49	deleterious	1	deleterious	0.70	deleterious	-1.69	low_impact	0.76	medium_impact	1.34	medium_impact	0.55	0.8	57.86	10.4	0.29	N	0.90	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9079	9079	A	T	MI.1174	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	553	185	N	Y	Aac/Tac	-9.13	0	0	possibly_damaging	0.8	neutral	1	neutral	4.46	neutral	-2.34	neutral	-2.31	neutral_impact	0.44	0.93	neutral	0.77	neutral	0.86	9.85	deleterious	0.37	0.65	0.53	disease	0.48	neutral	0.28	neutral	0.46	neutral	1	0.8	neutral	0.6	deleterious	-3	neutral	0.64	deleterious	-1.33	low_impact	1.98	high_impact	-0.72	medium_impact	0.33	0.9	21.24	18.74	0.2	N	0.92	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3784	3784	T	G	MI.11740	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	478	160	F	V	Ttt/Gtt	-7.59	0	0	probably_damaging	0.91	neutral	0.68	neutral	2.78	neutral	-0.45	deleterious	-6.26	medium_impact	3.17	0.69	neutral	0.51	neutral	4.04	23.70	deleterious	0.14	0.4	0.18	neutral	0.73	disease	0.72	disease	0.67	disease	3	0.9	neutral	0.39	neutral	1	deleterious	0.66	deleterious	-1.69	low_impact	0.46	medium_impact	1.58	medium_impact	0.38	0.8	57.86	10.4	0.31	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3784	3784	T	C	MI.11741	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	478	160	F	L	Ttt/Ctt	-7.59	0	0	possibly_damaging	0.81	neutral	1	neutral	2.86	neutral	1.23	deleterious	-5.4	low_impact	1.84	0.68	neutral	0.5	neutral	4.00	23.60	deleterious	0.25	0.45	0.13	neutral	0.58	disease	0.49	neutral	0.17	neutral	7	0.81	neutral	0.6	deleterious	-3	neutral	0.60	deleterious	-1.34	low_impact	1.96	high_impact	0.42	medium_impact	0.61	0.8	57.86	10.4	0.32	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3785	3785	T	C	MI.11742	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	479	160	F	S	tTt/tCt	7.34	1	0	probably_damaging	0.96	neutral	0.74	neutral	2.71	neutral	-1.49	deleterious	-7.18	high_impact	3.57	0.7	neutral	0.54	neutral	4.19	23.90	deleterious	0.08	0.35	0.3	neutral	0.76	disease	0.69	disease	0.66	disease	3	0.95	neutral	0.39	neutral	2	deleterious	0.73	deleterious	-2.05	low_impact	0.53	medium_impact	1.93	medium_impact	0.22	0.8	57.86	10.4	0.54	P	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3785	3785	T	G	MI.11743	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	479	160	F	C	tTt/tGt	7.34	1	0	probably_damaging	0.99	neutral	0.19	neutral	2.67	deleterious	-3.46	deleterious	-7.19	medium_impact	3.48	0.72	neutral	0.44	neutral	4.09	23.70	deleterious	0.07	0.35	0.43	neutral	0.81	disease	0.73	disease	0.69	disease	4	0.99	deleterious	0.1	neutral	1	deleterious	0.74	deleterious	-2.62	low_impact	-0.08	medium_impact	1.85	medium_impact	0.20	0.8	57.86	10.4	0.61	P	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3785	3785	T	A	MI.11744	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	479	160	F	Y	tTt/tAt	7.34	1	0	benign	0.17	neutral	0.99	neutral	2.72	neutral	-1.97	neutral	-2.26	low_impact	0.91	0.83	neutral	0.93	neutral	2.91	21.90	deleterious	0.22	0.45	0.25	neutral	0.3	neutral	0.49	neutral	0.39	neutral	2	0.14	neutral	0.91	deleterious	-6	neutral	0.22	neutral	-0.1	medium_impact	1.39	medium_impact	-0.39	medium_impact	0.70	0.85	57.86	10.4	0.55	N	0.28	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3786	3786	T	A	MI.11745	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	480	160	F	L	ttT/ttA	2.29	0.98	0.01	possibly_damaging	0.81	neutral	1	neutral	2.86	neutral	1.23	deleterious	-5.4	low_impact	1.84	0.68	neutral	0.5	neutral	4.39	24.10	deleterious	0.25	0.45	0.13	neutral	0.58	disease	0.49	neutral	0.17	neutral	7	0.81	neutral	0.6	deleterious	-3	neutral	0.60	deleterious	-1.34	low_impact	1.96	high_impact	0.42	medium_impact	0.61	0.8	57.86	10.4	0.44	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3786	3786	T	G	MI.11746	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	480	160	F	L	ttT/ttG	2.29	0.98	0.01	possibly_damaging	0.81	neutral	1	neutral	2.86	neutral	1.23	deleterious	-5.4	low_impact	1.84	0.68	neutral	0.5	neutral	4.29	24.00	deleterious	0.25	0.45	0.13	neutral	0.58	disease	0.49	neutral	0.17	neutral	7	0.81	neutral	0.6	deleterious	-3	neutral	0.60	deleterious	-1.34	low_impact	1.96	high_impact	0.42	medium_impact	0.61	0.8	57.86	10.4	0.44	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3787	3787	A	G	MI.11747	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	481	161	N	D	Aac/Gac	-4.15	0	0	possibly_damaging	0.56	neutral	0.17	neutral	2.6	neutral	-1.05	neutral	-1.45	low_impact	0.9	0.78	neutral	0.66	neutral	3.77	23.40	deleterious	0.53	0.6	0.34	neutral	0.44	neutral	0.47	neutral	0.42	neutral	2	0.82	neutral	0.31	neutral	-3	neutral	0.40	neutral	-0.85	medium_impact	-0.11	medium_impact	-0.4	medium_impact	0.36	0.8	27.36	41.44	0.36	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3787	3787	A	C	MI.11748	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	481	161	N	H	Aac/Cac	-4.15	0	0	probably_damaging	0.93	neutral	0.36	neutral	2.57	neutral	-2.73	neutral	-2.25	medium_impact	3.38	0.72	neutral	0.57	neutral	3.06	22.40	deleterious	0.31	0.45	0.38	neutral	0.48	neutral	0.65	disease	0.58	disease	2	0.93	neutral	0.22	neutral	1	deleterious	0.63	deleterious	-1.81	low_impact	0.14	medium_impact	1.76	medium_impact	0.22	0.8	27.36	41.44	0.42	N	0.42	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3787	3787	A	T	MI.11749	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	481	161	N	Y	Aac/Tac	-4.15	0	0	probably_damaging	0.95	neutral	0.8	neutral	2.56	deleterious	-3.7	deleterious	-2.81	medium_impact	2.84	0.71	neutral	0.64	neutral	3.69	23.30	deleterious	0.09	0.35	0.58	disease	0.56	disease	0.65	disease	0.68	disease	4	0.94	neutral	0.43	neutral	1	deleterious	0.70	deleterious	-1.95	low_impact	0.61	medium_impact	1.29	medium_impact	0.18	0.8	27.36	41.44	0.24	N	0.87	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9079	9079	A	G	MI.1175	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	553	185	N	D	Aac/Gac	-9.13	0	0	benign	0.19	neutral	0.25	neutral	4.39	neutral	-1.8	neutral	-1.55	low_impact	1.2	0.89	neutral	0.48	neutral	0.79	9.43	deleterious	0.66	0.7	0.71	disease	0.47	neutral	0.49	neutral	0.64	disease	3	0.7	neutral	0.53	deleterious	-6	neutral	0.37	neutral	-0.16	medium_impact	0.02	medium_impact	-0.07	medium_impact	0.49	0.9	21.24	18.74	0.38	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3788	3788	A	C	MI.11750	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	482	161	N	T	aAc/aCc	1.37	0.25	0	benign	0.06	neutral	0.48	neutral	2.69	neutral	-1.94	neutral	2.27	neutral_impact	-0.1	0.74	neutral	0.93	neutral	0.63	8.38	deleterious	0.27	0.45	0.24	neutral	0.08	neutral	0.36	neutral	0.26	neutral	5	0.47	neutral	0.71	deleterious	-6	neutral	0.09	neutral	0.37	medium_impact	0.26	medium_impact	-1.28	low_impact	0.28	0.8	27.36	41.44	0.41	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3788	3788	A	G	MI.11751	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	482	161	N	S	aAc/aGc	1.37	0.25	0	benign	0.06	neutral	0.73	neutral	2.74	neutral	0.39	neutral	0.3	neutral_impact	-0.38	0.79	neutral	0.98	neutral	1.62	13.95	neutral	0.49	0.55	0.16	neutral	0.21	neutral	0.36	neutral	0.35	neutral	3	0.18	neutral	0.84	deleterious	-6	neutral	0.11	neutral	0.37	medium_impact	0.52	medium_impact	-1.52	low_impact	0.18	0.8	27.36	41.44	0.29	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3788	3788	A	T	MI.11752	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	482	161	N	I	aAc/aTc	1.37	0.25	0	possibly_damaging	0.78	neutral	1	neutral	2.58	deleterious	-3.54	neutral	-2.3	medium_impact	3.38	0.83	neutral	0.66	neutral	3.89	23.50	deleterious	0.09	0.35	0.5	neutral	0.63	disease	0.61	disease	0.67	disease	3	0.78	neutral	0.61	deleterious	0	NA	0.59	deleterious	-1.27	low_impact	1.96	high_impact	1.76	medium_impact	0.13	0.8	27.36	41.44	0.25	N	0.77	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3789	3789	C	A	MI.11753	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	483	161	N	K	aaC/aaA	4.35	0.39	0	possibly_damaging	0.56	neutral	0.22	neutral	2.63	neutral	-1.09	neutral	-1.62	medium_impact	2.29	0.68	neutral	0.54	neutral	4.46	24.20	deleterious	0.37	0.5	0.24	neutral	0.51	disease	0.67	disease	0.58	disease	2	0.77	neutral	0.33	neutral	0	NA	0.39	neutral	-0.85	medium_impact	-0.03	medium_impact	0.81	medium_impact	0.45	0.8	27.36	41.44	0.48	N	0.69	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3789	3789	C	G	MI.11754	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	483	161	N	K	aaC/aaG	4.35	0.39	0	possibly_damaging	0.56	neutral	0.22	neutral	2.63	neutral	-1.09	neutral	-1.62	medium_impact	2.29	0.68	neutral	0.54	neutral	3.99	23.60	deleterious	0.37	0.5	0.24	neutral	0.51	disease	0.67	disease	0.58	disease	2	0.77	neutral	0.33	neutral	0	NA	0.39	neutral	-0.85	medium_impact	-0.03	medium_impact	0.81	medium_impact	0.45	0.8	27.36	41.44	0.48	N	0.69	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3790	3790	C	G	MI.11755	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	484	162	L	V	Ctc/Gtc	-8.97	0	0	possibly_damaging	0.54	neutral	0.58	neutral	2.72	neutral	-1.82	neutral	-2.46	medium_impact	3.26	0.71	neutral	0.56	neutral	3.40	23.00	deleterious	0.29	0.45	0.26	neutral	0.44	neutral	0.55	disease	0.45	neutral	1	0.48	neutral	0.52	deleterious	0	NA	0.43	neutral	-0.82	medium_impact	0.35	medium_impact	1.66	medium_impact	0.55	0.8	56.6	8.74	0.36	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3790	3790	C	A	MI.11756	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	484	162	L	I	Ctc/Atc	-8.97	0	0	benign	0.15	neutral	0.48	neutral	2.7	neutral	-1.63	neutral	-1.67	medium_impact	2.6	0.77	neutral	0.64	neutral	4.20	23.90	deleterious	0.32	0.5	0.18	neutral	0.44	neutral	0.38	neutral	0.4	neutral	2	0.43	neutral	0.67	deleterious	-3	neutral	0.20	neutral	-0.04	medium_impact	0.26	medium_impact	1.08	medium_impact	0.54	0.8	56.6	8.74	0.38	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3790	3790	C	T	MI.11757	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	484	162	L	F	Ctc/Ttc	-8.97	0	0	probably_damaging	0.96	neutral	0.89	neutral	2.67	neutral	-2.52	deleterious	-3.41	medium_impact	2.21	0.69	neutral	0.53	neutral	3.94	23.50	deleterious	0.19	0.45	0.28	neutral	0.46	neutral	0.43	neutral	0.37	neutral	3	0.95	neutral	0.47	neutral	1	deleterious	0.69	deleterious	-2.05	low_impact	0.78	medium_impact	0.74	medium_impact	0.57	0.8	56.6	8.74	0.27	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3791	3791	T	G	MI.11758	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	485	162	L	R	cTc/cGc	-0.24	0	0	probably_damaging	0.99	neutral	0.34	neutral	2.6	deleterious	-4.62	deleterious	-5.15	high_impact	4.62	0.66	neutral	0.36	neutral	4.20	23.90	deleterious	0.01	0.35	0.56	disease	0.82	disease	0.75	disease	0.71	disease	4	0.99	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-2.62	low_impact	0.11	medium_impact	2.85	high_impact	0.18	0.8	56.6	8.74	0.56	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3791	3791	T	C	MI.11759	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	485	162	L	P	cTc/cCc	-0.24	0	0	probably_damaging	0.99	neutral	0.19	neutral	2.58	deleterious	-3.88	deleterious	-6.05	high_impact	4.07	0.69	neutral	0.41	neutral	3.87	23.50	deleterious	0.01	0.35	0.65	disease	0.77	disease	0.75	disease	0.7	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-2.62	low_impact	-0.08	medium_impact	2.37	high_impact	0.16	0.8	56.6	8.74	0.43	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9079	9079	A	C	MI.1176	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	553	185	N	H	Aac/Cac	-9.13	0	0	possibly_damaging	0.8	neutral	0.54	neutral	4.37	neutral	-2.55	neutral	-1.41	low_impact	1.2	0.9	neutral	0.89	neutral	1.07	11.03	neutral	0.59	0.7	0.78	disease	0.4	neutral	0.33	neutral	0.66	disease	3	0.77	neutral	0.37	neutral	-3	neutral	0.67	deleterious	-1.33	low_impact	0.33	medium_impact	-0.07	medium_impact	0.46	0.9	21.24	18.74	0.31	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3791	3791	T	A	MI.11760	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	485	162	L	H	cTc/cAc	-0.24	0	0	probably_damaging	0.99	neutral	0.52	neutral	2.59	deleterious	-5.15	deleterious	-6.06	high_impact	4.26	0.7	neutral	0.39	neutral	4.10	23.70	deleterious	0.03	0.35	0.65	disease	0.76	disease	0.72	disease	0.68	disease	4	0.99	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-2.62	low_impact	0.29	medium_impact	2.53	high_impact	0.21	0.8	56.6	8.74	0.38	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3793	3793	T	C	MI.11761	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	487	163	S	P	Tcc/Ccc	-2.31	0	0	possibly_damaging	0.62	neutral	0.2	neutral	2.69	neutral	-2.81	neutral	-1.41	medium_impact	2.52	0.89	neutral	0.89	neutral	2.84	21.60	deleterious	0.07	0.35	0.48	neutral	0.72	disease	0.54	disease	0.3	neutral	4	0.81	neutral	0.29	neutral	0	NA	0.51	deleterious	-0.95	medium_impact	-0.06	medium_impact	1.01	medium_impact	0.17	0.8	33.33	40.26	0.42	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3793	3793	T	G	MI.11762	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	487	163	S	A	Tcc/Gcc	-2.31	0	0	benign	0.18	neutral	0.51	neutral	2.78	neutral	-1.38	neutral	-1.08	medium_impact	2.65	0.88	neutral	0.85	neutral	2.51	19.53	deleterious	0.33	0.5	0.24	neutral	0.21	neutral	0.36	neutral	0.37	neutral	3	0.39	neutral	0.67	deleterious	-3	neutral	0.16	neutral	-0.13	medium_impact	0.29	medium_impact	1.13	medium_impact	0.37	0.8	33.33	40.26	0.41	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3793	3793	T	A	MI.11763	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	487	163	S	T	Tcc/Acc	-2.31	0	0	benign	0.02	neutral	0.4	neutral	2.8	neutral	-0.98	neutral	-0.72	low_impact	0.9	0.85	neutral	0.98	neutral	2.49	19.42	deleterious	0.31	0.45	0.25	neutral	0.16	neutral	0.27	neutral	0.27	neutral	5	0.58	neutral	0.69	deleterious	-6	neutral	0.09	neutral	0.84	medium_impact	0.18	medium_impact	-0.4	medium_impact	0.57	0.8	33.33	40.26	0.46	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3794	3794	C	G	MI.11764	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	488	163	S	C	tCc/tGc	-1.16	0	0	possibly_damaging	0.89	neutral	0.18	neutral	2.68	deleterious	-5.32	deleterious	-2.57	medium_impact	3.07	0.8	neutral	0.4	neutral	3.53	23.10	deleterious	0.11	0.4	0.74	disease	0.54	disease	0.32	neutral	0.44	neutral	1	0.94	neutral	0.15	neutral	0	NA	0.67	deleterious	-1.6	low_impact	-0.09	medium_impact	1.49	medium_impact	0.27	0.8	33.33	40.26	0.38	N	0.46	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3794	3794	C	T	MI.11765	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	488	163	S	F	tCc/tTc	-1.16	0	0	benign	0.27	neutral	0.71	neutral	2.72	deleterious	-3.29	neutral	-2.28	low_impact	1.88	0.86	neutral	0.67	neutral	3.14	22.60	deleterious	0.08	0.35	0.6	disease	0.52	disease	0.32	neutral	0.31	neutral	4	0.2	neutral	0.72	deleterious	-6	neutral	0.30	neutral	-0.35	medium_impact	0.49	medium_impact	0.45	medium_impact	0.19	0.8	33.33	40.26	0.22	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3794	3794	C	A	MI.11766	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	488	163	S	Y	tCc/tAc	-1.16	0	0	benign	0.02	neutral	1	neutral	2.7	neutral	-2.63	neutral	-0.93	low_impact	1.73	0.87	neutral	0.74	neutral	2.83	21.50	deleterious	0.07	0.35	0.48	neutral	0.48	neutral	0.29	neutral	0.33	neutral	3	0.02	neutral	0.99	deleterious	-6	neutral	0.17	neutral	0.84	medium_impact	1.96	high_impact	0.32	medium_impact	0.25	0.8	33.33	40.26	0.24	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3796	3796	A	C	MI.11767	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	490	164	T	P	Acc/Ccc	-5.52	0	0.05	possibly_damaging	0.65	neutral	0.2	neutral	2.72	neutral	-2.22	deleterious	-4.32	medium_impact	3.1	0.6	neutral	0.33	neutral	3.58	23.20	deleterious	0.05	0.35	0.41	neutral	0.81	disease	0.51	disease	0.59	disease	2	0.82	neutral	0.28	neutral	0	NA	0.52	deleterious	-1	low_impact	-0.06	medium_impact	1.52	medium_impact	0.42	0.8	32.08	25.47	0.37	N	0.79	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3796	3796	A	G	MI.11768	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	490	164	T	A	Acc/Gcc	-5.52	0	0.05	benign	0.02	neutral	0.51	neutral	2.82	neutral	0.15	deleterious	-3.3	low_impact	1.15	0.91	neutral	0.9	neutral	0.92	10.18	neutral	0.29	0.45	0.19	neutral	0.35	neutral	0.31	neutral	0.43	neutral	1	0.47	neutral	0.75	deleterious	-6	neutral	0.13	neutral	0.84	medium_impact	0.29	medium_impact	-0.18	medium_impact	0.46	0.8	32.08	25.47	0.38	N	0.01	disease_causing_automatic	0	0.10	rs28357970	Pathogenic	Dystonia,_adult-onset	24769	MedGen:C0752197	.	.	CPD	2.67	A3796G	Adult-Onset Dystonia	-	+	Reported	3	N	P	N,P	neutral
chrM	3796	3796	A	T	MI.11769	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	490	164	T	S	Acc/Tcc	-5.52	0	0.05	benign	0.03	neutral	0.41	neutral	2.83	neutral	0.13	neutral	-2.25	neutral_impact	0.69	0.86	neutral	0.92	neutral	0.67	8.63	deleterious	0.3	0.45	0.17	neutral	0.35	neutral	0.21	neutral	0.44	neutral	1	0.57	neutral	0.69	deleterious	-6	neutral	0.13	neutral	0.67	medium_impact	0.19	medium_impact	-0.59	medium_impact	0.55	0.8	32.08	25.47	0.3	N	0.21	disease_causing_automatic	0	0.04	rs28357970	Likely_benign	not_provided	237334	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9080	9080	A	G	MI.1177	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	554	185	N	S	aAc/aGc	2.67	0.01	0	benign	0.01	neutral	0.54	neutral	4.51	neutral	-0.79	neutral	0.25	neutral_impact	-1.3	0.88	neutral	0.98	neutral	-1.02	0.01	neutral	0.68	0.75	0.43	neutral	0.16	neutral	0.23	neutral	0.31	neutral	4	0.44	neutral	0.77	deleterious	-6	neutral	0.13	neutral	1.14	medium_impact	0.33	medium_impact	-2.21	low_impact	0.23	0.9	21.24	18.74	0.36	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3797	3797	C	T	MI.11770	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	491	164	T	I	aCc/aTc	0.45	0	0	benign	0.36	neutral	0.4	neutral	2.73	neutral	-2.4	deleterious	-4.19	medium_impact	1.98	0.7	neutral	0.54	neutral	2.28	18.02	deleterious	0.18	0.45	0.39	neutral	0.68	disease	0.37	neutral	0.33	neutral	3	0.53	neutral	0.52	deleterious	-3	neutral	0.32	neutral	-0.52	medium_impact	0.18	medium_impact	0.54	medium_impact	0.58	0.8	32.08	25.47	0.34	N	0.61	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3797	3797	C	A	MI.11771	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	491	164	T	N	aCc/aAc	0.45	0	0	benign	0.36	neutral	0.31	neutral	2.77	neutral	-0.81	deleterious	-2.66	neutral_impact	0.6	0.87	neutral	0.92	neutral	1.85	15.28	deleterious	0.42	0.55	0.18	neutral	0.42	neutral	0.23	neutral	0.43	neutral	1	0.63	neutral	0.48	deleterious	-6	neutral	0.27	neutral	-0.52	medium_impact	0.08	medium_impact	-0.66	medium_impact	0.61	0.8	32.08	25.47	0.41	N	0.33	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3797	3797	C	G	MI.11772	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	491	164	T	S	aCc/aGc	0.45	0	0	benign	0.03	neutral	0.41	neutral	2.83	neutral	0.13	neutral	-2.25	neutral_impact	0.69	0.86	neutral	0.92	neutral	0.39	6.50	deleterious	0.3	0.45	0.17	neutral	0.35	neutral	0.21	neutral	0.44	neutral	1	0.57	neutral	0.69	deleterious	-6	neutral	0.13	neutral	0.67	medium_impact	0.19	medium_impact	-0.59	medium_impact	0.55	0.8	32.08	25.47	0.4	N	0.21	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3799	3799	C	A	MI.11773	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	493	165	L	I	Ctt/Att	-6.9	0	0	probably_damaging	1	neutral	0.41	neutral	2.87	neutral	2.09	neutral	-0.74	neutral_impact	0.5	0.75	neutral	0.13	damaging	4.09	23.70	deleterious	0.3	0.45	0.13	neutral	0.36	neutral	0.28	neutral	0.42	neutral	2	1	deleterious	0.21	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.19	medium_impact	-0.75	medium_impact	0.61	0.8	54.09	8.52	0.3	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3799	3799	C	G	MI.11774	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	493	165	L	V	Ctt/Gtt	-6.9	0	0	probably_damaging	1	neutral	0.52	neutral	2.69	neutral	-0.2	neutral	-1.61	low_impact	1.57	0.92	neutral	0.73	neutral	3.44	23.00	deleterious	0.31	0.5	0.22	neutral	0.45	neutral	0.32	neutral	0.45	neutral	1	1	deleterious	0.26	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.29	medium_impact	0.18	medium_impact	0.54	0.8	54.09	8.52	0.33	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3799	3799	C	T	MI.11775	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	493	165	L	F	Ctt/Ttt	-6.9	0	0	probably_damaging	1	neutral	0.75	neutral	2.64	neutral	-1.48	neutral	1.55	neutral_impact	-0.28	0.83	neutral	0.63	neutral	1.22	11.87	neutral	0.26	0.45	0.25	neutral	0.06	neutral	0.22	neutral	0.24	neutral	5	1	deleterious	0.38	neutral	-2	neutral	0.66	deleterious	-3.57	low_impact	0.54	medium_impact	-1.43	low_impact	0.58	0.8	54.09	8.52	0.27	N	0.95	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3800	3800	T	C	MI.11776	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	494	165	L	P	cTt/cCt	0.45	0.18	0	probably_damaging	1	neutral	0.21	neutral	2.54	deleterious	-3.68	deleterious	-4.79	medium_impact	3.27	0.79	neutral	0.1	damaging	3.85	23.40	deleterious	0.02	0.35	0.61	disease	0.87	disease	0.68	disease	0.75	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.87	deleterious	-3.57	low_impact	-0.05	medium_impact	1.67	medium_impact	0.20	0.8	54.09	8.52	0.28	N	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3800	3800	T	G	MI.11777	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	494	165	L	R	cTt/cGt	0.45	0.18	0	probably_damaging	1	neutral	0.34	neutral	2.55	deleterious	-3.1	deleterious	-3.87	high_impact	3.62	0.64	neutral	0.09	damaging	4.18	23.80	deleterious	0.01	0.35	0.52	disease	0.87	disease	0.67	disease	0.75	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.11	medium_impact	1.97	medium_impact	0.19	0.8	54.09	8.52	0.31	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3800	3800	T	A	MI.11778	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	494	165	L	H	cTt/cAt	0.45	0.18	0	probably_damaging	1	neutral	0.54	neutral	2.54	deleterious	-3.64	deleterious	-3.23	high_impact	3.62	0.71	neutral	0.1	damaging	4.07	23.70	deleterious	0.02	0.35	0.6	disease	0.72	disease	0.63	disease	0.7	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.31	medium_impact	1.97	medium_impact	0.24	0.8	54.09	8.52	0.25	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3802	3802	A	T	MI.11779	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	496	166	I	F	Atc/Ttc	-3.92	0	0	probably_damaging	0.98	neutral	0.71	neutral	2.78	neutral	-1.35	neutral	-1.16	low_impact	0.92	0.75	neutral	0.38	neutral	1.57	13.70	neutral	0.2	0.45	0.22	neutral	0.39	neutral	0.25	neutral	0.43	neutral	1	0.97	neutral	0.37	neutral	-2	neutral	0.62	deleterious	-2.34	low_impact	0.49	medium_impact	-0.39	medium_impact	0.68	0.85	22.64	17.53	0.25	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9080	9080	A	T	MI.1178	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	554	185	N	I	aAc/aTc	2.67	0.01	0	possibly_damaging	0.74	neutral	0.41	neutral	4.42	neutral	-1.58	deleterious	-2.51	neutral_impact	-0.24	0.84	neutral	0.71	neutral	2.03	16.39	deleterious	0.35	0.65	0.55	disease	0.55	disease	0.25	neutral	0.47	neutral	1	0.75	neutral	0.34	neutral	-3	neutral	0.58	deleterious	-1.19	low_impact	0.2	medium_impact	-1.3	low_impact	0.31	0.9	21.24	18.74	0.29	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3802	3802	A	G	MI.11780	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	496	166	I	V	Atc/Gtc	-3.92	0	0	possibly_damaging	0.83	neutral	0.51	neutral	2.95	neutral	2.2	neutral	-0.15	neutral_impact	0.72	0.82	neutral	0.68	neutral	1.16	11.52	neutral	0.55	0.6	0.12	neutral	0.09	neutral	0.27	neutral	0.26	neutral	5	0.81	neutral	0.34	neutral	-3	neutral	0.51	deleterious	-1.4	low_impact	0.29	medium_impact	-0.56	medium_impact	0.59	0.8	22.64	17.53	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3802	3802	A	C	MI.11781	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	496	166	I	L	Atc/Ctc	-3.92	0	0	possibly_damaging	0.78	neutral	0.66	neutral	2.84	neutral	0.05	neutral	-0.19	low_impact	1	0.82	neutral	0.68	neutral	1.61	13.93	neutral	0.26	0.45	0.17	neutral	0.26	neutral	0.3	neutral	0.42	neutral	2	0.73	neutral	0.44	neutral	-3	neutral	0.52	deleterious	-1.27	low_impact	0.44	medium_impact	-0.32	medium_impact	0.64	0.8	22.64	17.53	0.31	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3803	3803	T	C	MI.11782	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	497	166	I	T	aTc/aCc	1.6	0	0	possibly_damaging	0.83	neutral	0.4	neutral	2.77	neutral	-0.9	neutral	0.26	neutral_impact	0.63	0.83	neutral	0.92	neutral	1.68	14.29	neutral	0.11	0.4	0.22	neutral	0.19	neutral	0.28	neutral	0.34	neutral	3	0.84	neutral	0.29	neutral	-3	neutral	0.54	deleterious	-1.4	low_impact	0.18	medium_impact	-0.64	medium_impact	0.35	0.8	22.64	17.53	0.42	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3803	3803	T	G	MI.11783	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	497	166	I	S	aTc/aGc	1.6	0	0	possibly_damaging	0.83	neutral	0.41	neutral	2.77	neutral	-1.13	neutral	0.62	neutral_impact	0.58	0.8	neutral	0.81	neutral	2.44	19.07	deleterious	0.07	0.35	0.2	neutral	0.27	neutral	0.3	neutral	0.43	neutral	2	0.83	neutral	0.29	neutral	-3	neutral	0.52	deleterious	-1.4	low_impact	0.19	medium_impact	-0.68	medium_impact	0.21	0.8	22.64	17.53	0.34	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3803	3803	T	A	MI.11784	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	497	166	I	N	aTc/aAc	1.6	0	0	benign	0.12	neutral	0.32	neutral	2.74	neutral	-1.87	neutral	0.78	neutral_impact	0.25	0.83	neutral	0.9	neutral	2.60	20.20	deleterious	0.15	0.4	0.35	neutral	0.26	neutral	0.28	neutral	0.45	neutral	1	0.63	neutral	0.6	deleterious	-6	neutral	0.16	neutral	0.06	medium_impact	0.09	medium_impact	-0.97	medium_impact	0.23	0.8	22.64	17.53	0.45	N	0.88	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3804	3804	C	A	MI.11785	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	498	166	I	M	atC/atA	-0.24	0	0	probably_damaging	0.98	neutral	0.22	neutral	2.77	neutral	-1.28	neutral	0.22	low_impact	0.8	0.86	neutral	0.87	neutral	2.36	18.56	deleterious	0.37	0.5	0.29	neutral	0.15	neutral	0.25	neutral	0.29	neutral	4	0.98	deleterious	0.12	neutral	-2	neutral	0.62	deleterious	-2.34	low_impact	-0.03	medium_impact	-0.49	medium_impact	0.77	0.85	22.64	17.53	0.46	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3804	3804	C	G	MI.11786	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	498	166	I	M	atC/atG	-0.24	0	0	probably_damaging	0.98	neutral	0.22	neutral	2.77	neutral	-1.28	neutral	0.22	low_impact	0.8	0.86	neutral	0.87	neutral	1.91	15.67	deleterious	0.37	0.5	0.29	neutral	0.15	neutral	0.25	neutral	0.29	neutral	4	0.98	deleterious	0.12	neutral	-2	neutral	0.62	deleterious	-2.34	low_impact	-0.03	medium_impact	-0.49	medium_impact	0.77	0.85	22.64	17.53	0.45	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3805	3805	A	G	MI.11787	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	499	167	T	A	Aca/Gca	-3.69	0	0	benign	0.36	neutral	0.49	neutral	2.8	neutral	0.5	neutral	-2.01	low_impact	1.46	0.86	neutral	0.79	neutral	2.35	18.47	deleterious	0.27	0.45	0.15	neutral	0.34	neutral	0.27	neutral	0.44	neutral	1	0.43	neutral	0.57	deleterious	-6	neutral	0.24	neutral	-0.52	medium_impact	0.27	medium_impact	0.09	medium_impact	0.31	0.8	22.96	18.52	0.32	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3805	3805	A	T	MI.11788	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	499	167	T	S	Aca/Tca	-3.69	0	0	possibly_damaging	0.48	neutral	0.51	neutral	2.81	neutral	-0.17	neutral	-2.04	low_impact	0.89	0.83	neutral	0.92	neutral	2.19	17.43	deleterious	0.32	0.5	0.19	neutral	0.34	neutral	0.25	neutral	0.44	neutral	1	0.48	neutral	0.52	deleterious	-3	neutral	0.38	neutral	-0.72	medium_impact	0.29	medium_impact	-0.41	medium_impact	0.49	0.8	22.96	18.52	0.32	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3805	3805	A	C	MI.11789	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	499	167	T	P	Aca/Cca	-3.69	0	0	possibly_damaging	0.87	neutral	0.16	neutral	2.73	neutral	-2.28	deleterious	-3.41	medium_impact	2.81	0.82	neutral	0.44	neutral	3.44	23.00	deleterious	0.05	0.35	0.44	neutral	0.8	disease	0.43	neutral	0.61	disease	2	0.93	neutral	0.15	neutral	0	NA	0.68	deleterious	-1.53	low_impact	-0.13	medium_impact	1.27	medium_impact	0.32	0.8	22.96	18.52	0.33	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9080	9080	A	C	MI.1179	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	554	185	N	T	aAc/aCc	2.67	0.01	0	benign	0.19	neutral	0.45	neutral	4.47	neutral	-1.1	neutral	-1.06	neutral_impact	0.57	0.91	neutral	0.87	neutral	-0.03	2.35	deleterious	0.56	0.65	0.61	disease	0.26	neutral	0.39	neutral	0.56	disease	1	0.46	neutral	0.63	deleterious	-6	neutral	0.27	neutral	-0.16	medium_impact	0.24	medium_impact	-0.61	medium_impact	0.41	0.9	21.24	18.74	0.4	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3806	3806	C	A	MI.11790	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	500	167	T	K	aCa/aAa	-0.47	0	0	benign	0.04	neutral	0.3	neutral	2.82	neutral	-0.04	deleterious	-3.25	low_impact	1.16	0.76	neutral	0.55	neutral	4.41	24.10	deleterious	0.1	0.4	0.19	neutral	0.61	disease	0.23	neutral	0.22	neutral	6	0.68	neutral	0.63	deleterious	-6	neutral	0.15	neutral	0.55	medium_impact	0.07	medium_impact	-0.18	medium_impact	0.33	0.8	22.96	18.52	0.41	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3806	3806	C	T	MI.11791	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	500	167	T	M	aCa/aTa	-0.47	0	0	benign	0.25	neutral	0.29	neutral	2.74	neutral	-2.12	neutral	-1.55	neutral_impact	0.68	0.88	neutral	0.88	neutral	2.94	22.00	deleterious	0.15	0.4	0.34	neutral	0.39	neutral	0.19	neutral	0.46	neutral	1	0.65	neutral	0.52	deleterious	-6	neutral	0.23	neutral	-0.3	medium_impact	0.06	medium_impact	-0.59	medium_impact	0.39	0.8	22.96	18.52	0.51	N	0.80	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3808	3808	A	C	MI.11792	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	502	168	T	P	Aca/Cca	-8.05	0	0	probably_damaging	0.96	neutral	0.2	neutral	2.7	neutral	-2.47	deleterious	-4.11	medium_impact	3.08	0.61	neutral	0.31	neutral	1.53	13.46	neutral	0.05	0.35	0.51	disease	0.82	disease	0.68	disease	0.72	disease	4	0.97	neutral	0.12	neutral	1	deleterious	0.76	deleterious	-2.05	low_impact	-0.06	medium_impact	1.5	medium_impact	0.40	0.8	55.35	8.8	0.31	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3808	3808	A	T	MI.11793	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	502	168	T	S	Aca/Tca	-8.05	0	0	possibly_damaging	0.74	neutral	0.49	neutral	2.78	neutral	0.29	neutral	-2.17	neutral_impact	0.54	0.85	neutral	0.84	neutral	1.56	13.61	neutral	0.28	0.45	0.24	neutral	0.39	neutral	0.42	neutral	0.44	neutral	1	0.72	neutral	0.38	neutral	-3	neutral	0.52	deleterious	-1.18	low_impact	0.27	medium_impact	-0.72	medium_impact	0.61	0.8	55.35	8.8	0.31	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3808	3808	A	G	MI.11794	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	502	168	T	A	Aca/Gca	-8.05	0	0	benign	0.08	neutral	0.53	neutral	2.88	neutral	1.38	neutral	-2.24	neutral_impact	0.49	0.91	neutral	0.61	neutral	0.18	4.42	deleterious	0.26	0.45	0.13	neutral	0.14	neutral	0.41	neutral	0.24	neutral	5	0.4	neutral	0.73	deleterious	-6	neutral	0.12	neutral	0.25	medium_impact	0.3	medium_impact	-0.76	medium_impact	0.23	0.8	55.35	8.8	0.28	N	0.65	polymorphism	1	0.08	rs2854135	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3809	3809	C	T	MI.11795	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	503	168	T	M	aCa/aTa	0.91	0.28	0	probably_damaging	0.98	neutral	0.28	neutral	2.72	neutral	-1.04	deleterious	-4	low_impact	1.86	0.7	neutral	0.48	neutral	3.87	23.50	deleterious	0.14	0.4	0.44	neutral	0.57	disease	0.48	neutral	0.48	neutral	0	0.99	deleterious	0.15	neutral	-2	neutral	0.70	deleterious	-2.34	low_impact	0.05	medium_impact	0.44	medium_impact	0.58	0.8	55.35	8.8	0.37	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3809	3809	C	A	MI.11796	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	503	168	T	K	aCa/aAa	0.91	0.28	0	possibly_damaging	0.83	neutral	0.38	neutral	2.77	neutral	-0.39	deleterious	-4.05	medium_impact	2.52	0.69	neutral	0.34	neutral	2.80	21.40	deleterious	0.07	0.35	0.25	neutral	0.73	disease	0.61	disease	0.67	disease	3	0.84	neutral	0.28	neutral	0	NA	0.68	deleterious	-1.4	low_impact	0.16	medium_impact	1.01	medium_impact	0.33	0.8	55.35	8.8	0.32	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3811	3811	C	G	MI.11797	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	505	169	Q	E	Caa/Gaa	-6.21	0	0	probably_damaging	1	neutral	0.32	neutral	2.59	neutral	-2.47	deleterious	-2.76	high_impact	3.66	0.72	neutral	0.12	damaging	3.08	22.50	deleterious	0.24	0.45	0.32	neutral	0.63	disease	0.79	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.09	medium_impact	2.01	high_impact	0.28	0.8	58.49	10.49	0.42	N	0.93	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3811	3811	C	A	MI.11798	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	505	169	Q	K	Caa/Aaa	-6.21	0	0	probably_damaging	1	neutral	0.34	neutral	2.58	neutral	-2.54	deleterious	-3.68	high_impact	3.78	0.69	neutral	0.1	damaging	3.97	23.60	deleterious	0.14	0.4	0.34	neutral	0.72	disease	0.8	disease	0.72	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.11	medium_impact	2.11	high_impact	0.21	0.8	58.49	10.49	0.41	N	0.98	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3812	3812	A	T	MI.11799	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	506	169	Q	L	cAa/cTa	5.5	1	0	probably_damaging	1	neutral	0.69	neutral	2.49	deleterious	-4.01	deleterious	-6.45	high_impact	3.78	0.67	neutral	0.08	damaging	3.61	23.20	deleterious	0.06	0.35	0.34	neutral	0.8	disease	0.71	disease	0.71	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.47	medium_impact	2.11	high_impact	0.10	0.8	58.49	10.49	0.5	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8581	8581	G	T	MI.118	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	55	19	A	S	Gcc/Tcc	-4.73	0	0	probably_damaging	0.99	deleterious	0.02	neutral	4.65	neutral	-1.02	neutral	-1.23	neutral_impact	0.11	0.79	neutral	0.65	neutral	3.51	23.10	deleterious	0.29	0.65	0.33	neutral	0.41	neutral	0.24	neutral	0.48	neutral	0	1	deleterious	0.02	neutral	2	deleterious	0.71	deleterious	-2.65	low_impact	-0.66	medium_impact	-1	low_impact	0.58	0.9	29.65	29.28	0.38	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9081	9081	C	G	MI.1180	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	555	185	N	K	aaC/aaG	-0.33	0	0	benign	0.28	neutral	0.36	neutral	4.42	neutral	-1.06	neutral	-1.53	low_impact	1	0.89	neutral	0.48	neutral	0.79	9.42	deleterious	0.68	0.75	0.54	disease	0.5	neutral	0.5	neutral	0.51	disease	0	0.56	neutral	0.54	deleterious	-6	neutral	0.38	neutral	-0.37	medium_impact	0.15	medium_impact	-0.24	medium_impact	0.47	0.9	21.24	18.74	0.33	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3812	3812	A	G	MI.11800	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	506	169	Q	R	cAa/cGa	5.5	1	0	probably_damaging	1	neutral	0.37	neutral	2.53	deleterious	-3.06	deleterious	-3.68	high_impact	4.01	0.71	neutral	0.1	damaging	3.34	22.90	deleterious	0.15	0.4	0.42	neutral	0.74	disease	0.81	disease	0.72	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.15	medium_impact	2.31	high_impact	0.16	0.8	58.49	10.49	0.69	P	0.95	polymorphism	0.98	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3812	3812	A	C	MI.11801	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	506	169	Q	P	cAa/cCa	5.5	1	0	probably_damaging	1	neutral	0.21	neutral	2.47	deleterious	-4.18	deleterious	-5.53	high_impact	3.92	0.69	neutral	0.1	damaging	3.19	22.70	deleterious	0.05	0.35	0.63	disease	0.77	disease	0.81	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.05	medium_impact	2.24	high_impact	0.14	0.8	58.49	10.49	0.67	P	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3813	3813	A	T	MI.11802	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	507	169	Q	H	caA/caT	8.49	1	0	probably_damaging	1	neutral	0.54	neutral	2.49	deleterious	-4.1	deleterious	-4.61	high_impact	4.27	0.66	neutral	0.09	damaging	3.58	23.20	deleterious	0.15	0.4	0.59	disease	0.72	disease	0.81	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.31	medium_impact	2.54	high_impact	0.38	0.8	58.49	10.49	0.67	P	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3813	3813	A	C	MI.11803	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	507	169	Q	H	caA/caC	8.49	1	0	probably_damaging	1	neutral	0.54	neutral	2.49	deleterious	-4.1	deleterious	-4.61	high_impact	4.27	0.66	neutral	0.09	damaging	3.41	23.00	deleterious	0.15	0.4	0.59	disease	0.72	disease	0.81	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.31	medium_impact	2.54	high_impact	0.38	0.8	58.49	10.49	0.67	P	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3814	3814	G	A	MI.11804	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	508	170	E	K	Gaa/Aaa	2.52	1	0	probably_damaging	1	neutral	0.37	neutral	2.77	neutral	-0.23	deleterious	-3.5	low_impact	1.72	0.79	neutral	0.44	neutral	4.44	24.20	deleterious	0.13	0.4	0.19	neutral	0.51	disease	0.34	neutral	0.41	neutral	2	1	deleterious	0.19	neutral	-2	neutral	0.72	deleterious	-3.57	low_impact	0.15	medium_impact	0.31	medium_impact	0.51	0.8	57.23	9.28	0.47	N	0.47	polymorphism	1	0.08	.	.	.	.	.	.	COSM6188310	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3814	3814	G	C	MI.11805	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	508	170	E	Q	Gaa/Caa	2.52	1	0	probably_damaging	1	neutral	0.37	neutral	2.72	neutral	-0.04	deleterious	-2.65	low_impact	1.04	0.79	neutral	0.23	damaging	3.32	22.90	deleterious	0.43	0.55	0.26	neutral	0.46	neutral	0.26	neutral	0.42	neutral	2	1	deleterious	0.19	neutral	-2	neutral	0.70	deleterious	-3.57	low_impact	0.15	medium_impact	-0.28	medium_impact	0.63	0.8	57.23	9.28	0.42	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3815	3815	A	T	MI.11806	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	509	170	E	V	gAa/gTa	5.96	1	0	probably_damaging	1	neutral	0.56	neutral	2.69	neutral	-1.77	deleterious	-6.37	medium_impact	2.48	0.69	neutral	0.12	damaging	4.04	23.70	deleterious	0.15	0.45	0.28	neutral	0.62	disease	0.57	disease	0.64	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.33	medium_impact	0.98	medium_impact	0.39	0.8	57.23	9.28	0.46	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3815	3815	A	G	MI.11807	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	509	170	E	G	gAa/gGa	5.96	1	0	probably_damaging	1	neutral	0.37	neutral	2.68	neutral	-1.18	deleterious	-6.36	medium_impact	2.44	0.75	neutral	0.15	damaging	4.16	23.80	deleterious	0.22	0.45	0.21	neutral	0.49	neutral	0.49	neutral	0.43	neutral	1	1	deleterious	0.19	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.15	medium_impact	0.94	medium_impact	0.28	0.8	57.23	9.28	0.56	P	0.83	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3815	3815	A	C	MI.11808	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	509	170	E	A	gAa/gCa	5.96	1	0	probably_damaging	1	neutral	0.56	neutral	2.76	neutral	0	deleterious	-5.44	medium_impact	2.31	0.75	neutral	0.14	damaging	3.60	23.20	deleterious	0.28	0.45	0.22	neutral	0.5	neutral	0.54	disease	0.6	disease	2	1	deleterious	0.28	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.33	medium_impact	0.83	medium_impact	0.31	0.8	57.23	9.28	0.49	N	0.79	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3816	3816	A	C	MI.11809	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	510	170	E	D	gaA/gaC	8.49	1	0	probably_damaging	1	neutral	0.27	neutral	2.71	neutral	-0.94	deleterious	-2.74	medium_impact	2.74	0.76	neutral	0.11	damaging	3.66	23.20	deleterious	0.44	0.55	0.29	neutral	0.48	neutral	0.25	neutral	0.46	neutral	1	1	deleterious	0.14	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.03	medium_impact	1.2	medium_impact	0.59	0.8	57.23	9.28	0.6	P	0.90	polymorphism	1	0.07	rs386828924	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9081	9081	C	A	MI.1181	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	555	185	N	K	aaC/aaA	-0.33	0	0	benign	0.28	neutral	0.36	neutral	4.42	neutral	-1.06	neutral	-1.53	low_impact	1	0.89	neutral	0.48	neutral	1.26	12.09	neutral	0.68	0.75	0.54	disease	0.5	neutral	0.5	neutral	0.51	disease	0	0.56	neutral	0.54	deleterious	-6	neutral	0.38	neutral	-0.37	medium_impact	0.15	medium_impact	-0.24	medium_impact	0.47	0.9	21.24	18.74	0.34	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3816	3816	A	T	MI.11810	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	510	170	E	D	gaA/gaT	8.49	1	0	probably_damaging	1	neutral	0.27	neutral	2.71	neutral	-0.94	deleterious	-2.74	medium_impact	2.74	0.76	neutral	0.11	damaging	3.73	23.30	deleterious	0.44	0.55	0.29	neutral	0.48	neutral	0.25	neutral	0.46	neutral	1	1	deleterious	0.14	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.03	medium_impact	1.2	medium_impact	0.59	0.8	57.23	9.28	0.61	P	0.90	polymorphism	1	0.07	rs386828924	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3817	3817	C	T	MI.11811	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	511	171	H	Y	Cac/Tac	-0.01	0	0.01	benign	0	neutral	1	neutral	2.81	neutral	-1.55	neutral	-0.85	neutral_impact	-0.28	0.83	neutral	0.96	neutral	-0.78	0.05	neutral	0.25	0.45	0.17	neutral	0.11	neutral	0.29	neutral	0.24	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	1.96	high_impact	-1.43	low_impact	0.24	0.8	24.84	26.33	0.33	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3817	3817	C	G	MI.11812	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	511	171	H	D	Cac/Gac	-0.01	0	0.01	benign	0.11	neutral	0.21	neutral	2.81	neutral	-0.75	neutral	-1.39	low_impact	1.15	0.77	neutral	0.47	neutral	0.63	8.38	deleterious	0.08	0.35	0.14	neutral	0.27	neutral	0.5	neutral	0.42	neutral	2	0.76	neutral	0.55	deleterious	-6	neutral	0.14	neutral	0.1	medium_impact	-0.05	medium_impact	-0.18	medium_impact	0.41	0.8	24.84	26.33	0.39	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3817	3817	C	A	MI.11813	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	511	171	H	N	Cac/Aac	-0.01	0	0.01	benign	0.01	neutral	0.34	neutral	2.82	neutral	-0.33	neutral	-0.38	neutral_impact	-0.43	0.84	neutral	0.92	neutral	0.17	4.36	deleterious	0.28	0.45	0.15	neutral	0.15	neutral	0.38	neutral	0.3	neutral	4	0.65	neutral	0.67	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.11	medium_impact	-1.56	low_impact	0.37	0.8	24.84	26.33	0.39	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3818	3818	A	C	MI.11814	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	512	171	H	P	cAc/cCc	-1.85	0	0	possibly_damaging	0.49	neutral	0.2	neutral	2.8	neutral	-1.08	neutral	-0.88	neutral_impact	0.54	0.84	neutral	0.9	neutral	-0.27	0.77	neutral	0.08	0.35	0.26	neutral	0.42	neutral	0.56	disease	0.46	neutral	1	0.78	neutral	0.36	neutral	-3	neutral	0.34	neutral	-0.74	medium_impact	-0.06	medium_impact	-0.72	medium_impact	0.29	0.8	24.84	26.33	0.39	N	0.97	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3818	3818	A	G	MI.11815	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	512	171	H	R	cAc/cGc	-1.85	0	0	benign	0.01	neutral	0.34	neutral	2.83	neutral	-0.9	neutral	-1.42	low_impact	1.52	0.9	neutral	0.68	neutral	-0.62	0.11	neutral	0.14	0.4	0.19	neutral	0.25	neutral	0.42	neutral	0.43	neutral	2	0.65	neutral	0.67	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.11	medium_impact	0.14	medium_impact	0.21	0.8	24.84	26.33	0.46	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3818	3818	A	T	MI.11816	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	512	171	H	L	cAc/cTc	-1.85	0	0	benign	0.11	neutral	0.66	neutral	2.9	neutral	-1.45	neutral	-2.35	neutral_impact	0.32	0.88	neutral	0.89	neutral	-0.14	1.43	neutral	0.1	0.4	0.21	neutral	0.29	neutral	0.43	neutral	0.42	neutral	2	0.23	neutral	0.78	deleterious	-6	neutral	0.15	neutral	0.1	medium_impact	0.44	medium_impact	-0.91	medium_impact	0.17	0.8	24.84	26.33	0.31	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3819	3819	C	G	MI.11817	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	513	171	H	Q	caC/caG	0.45	0	0	benign	0.01	neutral	0.34	neutral	2.85	neutral	-0.5	neutral	-0.84	neutral_impact	0.19	0.85	neutral	0.92	neutral	0.16	4.29	deleterious	0.22	0.45	0.14	neutral	0.13	neutral	0.35	neutral	0.31	neutral	4	0.65	neutral	0.67	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.11	medium_impact	-1.02	low_impact	0.34	0.8	24.84	26.33	0.45	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3819	3819	C	A	MI.11818	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	513	171	H	Q	caC/caA	0.45	0	0	benign	0.01	neutral	0.34	neutral	2.85	neutral	-0.5	neutral	-0.84	neutral_impact	0.19	0.85	neutral	0.92	neutral	0.50	7.43	deleterious	0.22	0.45	0.14	neutral	0.13	neutral	0.35	neutral	0.31	neutral	4	0.65	neutral	0.67	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.11	medium_impact	-1.02	low_impact	0.34	0.8	24.84	26.33	0.45	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3820	3820	C	G	MI.11819	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	514	172	L	V	Ctc/Gtc	-6.21	0	0	benign	0.07	neutral	0.54	neutral	2.8	neutral	-0.78	neutral	0.25	low_impact	0.94	0.84	neutral	0.96	neutral	-0.25	0.86	neutral	0.35	0.5	0.17	neutral	0.07	neutral	0.25	neutral	0.24	neutral	5	0.4	neutral	0.74	deleterious	-6	neutral	0.13	neutral	0.3	medium_impact	0.31	medium_impact	-0.37	medium_impact	0.46	0.8	20.13	21.45	0.4	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9082	9082	C	G	MI.1182	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	556	186	L	V	Ctt/Gtt	-1.49	0	0	benign	0.32	neutral	0.52	neutral	4.35	neutral	-0.57	neutral	-0.29	neutral_impact	0.12	0.94	neutral	0.86	neutral	0.47	7.16	deleterious	0.48	0.65	0.32	neutral	0.33	neutral	0.34	neutral	0.46	neutral	1	0.39	neutral	0.6	deleterious	-6	neutral	0.40	neutral	-0.45	medium_impact	0.31	medium_impact	-1	medium_impact	0.59	0.9	28.32	18.04	0.31	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3820	3820	C	T	MI.11820	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	514	172	L	F	Ctc/Ttc	-6.21	0	0	benign	0.02	neutral	0.74	neutral	2.7	neutral	-2.07	neutral	-1.69	low_impact	1.49	0.84	neutral	0.78	neutral	0.93	10.28	neutral	0.24	0.45	0.34	neutral	0.22	neutral	0.37	neutral	0.4	neutral	2	0.22	neutral	0.86	deleterious	-6	neutral	0.15	neutral	0.84	medium_impact	0.53	medium_impact	0.11	medium_impact	0.48	0.8	20.13	21.45	0.28	N	0.28	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3820	3820	C	A	MI.11821	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	514	172	L	I	Ctc/Atc	-6.21	0	0	benign	0.01	neutral	0.42	neutral	2.78	neutral	-0.83	neutral	0.38	neutral_impact	-0.26	0.78	neutral	0.96	neutral	-0.46	0.28	neutral	0.32	0.5	0.17	neutral	0.03	neutral	0.2	neutral	0.19	neutral	6	0.57	neutral	0.71	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.2	medium_impact	-1.42	low_impact	0.42	0.8	20.13	21.45	0.48	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3821	3821	T	C	MI.11822	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	515	172	L	P	cTc/cCc	-1.62	0	0	possibly_damaging	0.66	neutral	0.25	neutral	2.67	neutral	-2.92	deleterious	-3.19	low_impact	1.64	0.69	neutral	0.37	neutral	2.02	16.31	deleterious	0.02	0.35	0.6	disease	0.65	disease	0.7	disease	0.73	disease	5	0.78	neutral	0.3	neutral	-3	neutral	0.59	deleterious	-1.02	low_impact	0.01	medium_impact	0.24	medium_impact	0.11	0.8	20.13	21.45	0.29	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3821	3821	T	G	MI.11823	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	515	172	L	R	cTc/cGc	-1.62	0	0	possibly_damaging	0.47	neutral	0.43	neutral	2.7	deleterious	-3.03	deleterious	-2.91	medium_impact	2.8	0.73	neutral	0.46	neutral	2.29	18.11	deleterious	0.02	0.35	0.42	neutral	0.56	disease	0.71	disease	0.72	disease	4	0.54	neutral	0.48	deleterious	0	NA	0.47	deleterious	-0.7	medium_impact	0.21	medium_impact	1.26	medium_impact	0.20	0.8	20.13	21.45	0.32	N	0.37	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3821	3821	T	A	MI.11824	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	515	172	L	H	cTc/cAc	-1.62	0	0	possibly_damaging	0.67	neutral	0.54	neutral	2.68	neutral	-2.9	deleterious	-3.37	medium_impact	1.94	0.74	neutral	0.62	neutral	3.60	23.20	deleterious	0.05	0.35	0.43	neutral	0.37	neutral	0.67	disease	0.5	neutral	0	0.63	neutral	0.44	neutral	0	NA	0.44	deleterious	-1.04	low_impact	0.31	medium_impact	0.51	medium_impact	0.15	0.8	20.13	21.45	0.28	N	0.46	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3823	3823	T	G	MI.11825	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	517	173	W	G	Tga/Gga	-7.13	0	0	probably_damaging	1	neutral	0.33	neutral	2.41	deleterious	-4.05	deleterious	-11.24	high_impact	3.69	0.78	neutral	0.12	damaging	3.86	23.50	deleterious	0.05	0.35	0.68	disease	0.67	disease	0.81	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.1	medium_impact	2.03	high_impact	0.07	0.8	58.49	10.4	0.37	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3823	3823	T	C	MI.11826	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	517	173	W	R	Tga/Cga	-7.13	0	0	probably_damaging	1	neutral	0.34	neutral	2.42	deleterious	-3.44	deleterious	-11.98	high_impact	4.67	0.7	neutral	0.09	damaging	3.55	23.10	deleterious	0.03	0.35	0.65	disease	0.79	disease	0.85	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.11	medium_impact	2.89	high_impact	0.09	0.8	58.49	10.4	0.55	N	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3824	3824	G	T	MI.11827	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	518	173	W	L	tGa/tTa	4.58	1	0	probably_damaging	1	neutral	0.67	neutral	2.49	neutral	-2.09	deleterious	-11.01	medium_impact	2.62	0.76	neutral	0.1	damaging	4.28	24.00	deleterious	0.07	0.35	0.28	neutral	0.71	disease	0.78	disease	0.68	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.45	medium_impact	1.1	medium_impact	0.08	0.8	58.49	10.4	0.44	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3824	3824	G	C	MI.11828	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	518	173	W	S	tGa/tCa	4.58	1	0	probably_damaging	1	neutral	0.43	neutral	2.43	deleterious	-3.08	deleterious	-11.97	medium_impact	3.15	0.79	neutral	0.13	damaging	4.09	23.70	deleterious	0.05	0.35	0.45	neutral	0.74	disease	0.77	disease	0.58	disease	2	1	deleterious	0.22	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.21	medium_impact	1.56	medium_impact	0.08	0.8	58.49	10.4	0.48	N	0.99	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3825	3825	A	C	MI.11829	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	519	173	W	C	tgA/tgC	4.81	1	0	probably_damaging	1	neutral	0.18	neutral	2.39	deleterious	-5.05	deleterious	-11.13	medium_impact	3.47	0.74	neutral	0.09	damaging	4.02	23.60	deleterious	0.04	0.35	0.74	disease	0.76	disease	0.79	disease	0.69	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	-0.09	medium_impact	1.84	medium_impact	0.10	0.8	58.49	10.4	0.56	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9082	9082	C	T	MI.1183	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	556	186	L	F	Ctt/Ttt	-1.49	0	0	possibly_damaging	0.81	neutral	0.7	neutral	4.33	neutral	-1.46	neutral	-1.45	neutral_impact	0.68	0.93	neutral	0.9	neutral	2.57	19.89	deleterious	0.45	0.65	0.68	disease	0.47	neutral	0.22	neutral	0.59	disease	2	0.77	neutral	0.45	neutral	-3	neutral	0.70	deleterious	-1.35	low_impact	0.5	medium_impact	-0.52	medium_impact	0.59	0.9	28.32	18.04	0.28	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3825	3825	A	T	MI.11830	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	519	173	W	C	tgA/tgT	4.81	1	0	probably_damaging	1	neutral	0.18	neutral	2.39	deleterious	-5.05	deleterious	-11.13	medium_impact	3.47	0.74	neutral	0.09	damaging	4.10	23.70	deleterious	0.04	0.35	0.74	disease	0.76	disease	0.79	disease	0.69	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	-0.09	medium_impact	1.84	medium_impact	0.10	0.8	58.49	10.4	0.56	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3826	3826	T	G	MI.11831	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	520	174	L	V	Tta/Gta	1.83	0.91	0	possibly_damaging	0.74	neutral	0.52	neutral	2.74	neutral	-1.16	deleterious	-2.56	medium_impact	2.54	0.79	neutral	0.54	neutral	3.39	23.00	deleterious	0.27	0.45	0.27	neutral	0.33	neutral	0.56	disease	0.46	neutral	1	0.72	neutral	0.39	neutral	0	NA	0.54	deleterious	-1.18	low_impact	0.29	medium_impact	1.03	medium_impact	0.62	0.8	55.03	9.73	0.36	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3826	3826	T	A	MI.11832	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	520	174	L	M	Tta/Ata	1.83	0.91	0	possibly_damaging	0.52	neutral	0.23	neutral	2.67	neutral	-2.3	neutral	-1.46	medium_impact	1.94	0.85	neutral	0.86	neutral	2.54	19.70	deleterious	0.24	0.45	0.39	neutral	0.27	neutral	0.3	neutral	0.46	neutral	1	0.75	neutral	0.36	neutral	0	NA	0.43	deleterious	-0.78	medium_impact	-0.02	medium_impact	0.51	medium_impact	0.49	0.8	55.03	9.73	0.46	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3827	3827	T	C	MI.11833	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	521	174	L	S	tTa/tCa	-1.85	0	0	probably_damaging	0.94	neutral	0.44	neutral	2.73	neutral	-2.05	deleterious	-5.21	medium_impact	2.54	0.7	neutral	0.55	neutral	3.77	23.40	deleterious	0.05	0.35	0.34	neutral	0.5	neutral	0.59	disease	0.63	disease	3	0.94	neutral	0.25	neutral	1	deleterious	0.68	deleterious	-1.87	low_impact	0.22	medium_impact	1.03	medium_impact	0.28	0.8	55.03	9.73	0.3	N	0.97	polymorphism	1	0.12	rs879048761	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3827	3827	T	G	MI.11834	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	521	174	L	W	tTa/tGa	-1.85	0	0	probably_damaging	0.98	neutral	0.19	neutral	2.64	deleterious	-3.35	deleterious	-5.14	medium_impact	2.98	0.68	neutral	0.41	neutral	3.75	23.30	deleterious	0.06	0.35	0.74	disease	0.61	disease	0.61	disease	0.65	disease	3	0.99	deleterious	0.11	neutral	1	deleterious	0.77	deleterious	-2.34	low_impact	-0.08	medium_impact	1.41	medium_impact	0.26	0.8	55.03	9.73	0.31	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3828	3828	A	C	MI.11835	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	522	174	L	F	ttA/ttC	7.34	0.95	0	benign	0.17	neutral	0.71	neutral	2.72	neutral	-0.93	deleterious	-3.27	low_impact	0.82	0.83	neutral	0.84	neutral	2.33	18.35	deleterious	0.25	0.45	0.25	neutral	0.09	neutral	0.24	neutral	0.28	neutral	4	0.17	neutral	0.77	deleterious	-6	neutral	0.19	neutral	-0.1	medium_impact	0.49	medium_impact	-0.47	medium_impact	0.56	0.8	55.03	9.73	0.54	P	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3828	3828	A	T	MI.11836	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	522	174	L	F	ttA/ttT	7.34	0.95	0	benign	0.17	neutral	0.71	neutral	2.72	neutral	-0.93	deleterious	-3.27	low_impact	0.82	0.83	neutral	0.84	neutral	2.47	19.27	deleterious	0.25	0.45	0.25	neutral	0.09	neutral	0.24	neutral	0.28	neutral	4	0.17	neutral	0.77	deleterious	-6	neutral	0.19	neutral	-0.1	medium_impact	0.49	medium_impact	-0.47	medium_impact	0.56	0.8	55.03	9.73	0.55	P	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3829	3829	C	T	MI.11837	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	523	175	L	F	Ctc/Ttc	-5.52	0	0	benign	0.02	neutral	0.7	neutral	2.64	neutral	-1.41	neutral	-2.4	low_impact	1.24	0.88	neutral	0.87	neutral	0.97	10.47	neutral	0.22	0.45	0.36	neutral	0.29	neutral	0.29	neutral	0.46	neutral	1	0.26	neutral	0.84	deleterious	-6	neutral	0.17	neutral	0.84	medium_impact	0.48	medium_impact	-0.11	medium_impact	0.54	0.8	19.81	23.12	0.31	N	0.37	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3829	3829	C	A	MI.11838	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	523	175	L	I	Ctc/Atc	-5.52	0	0	benign	0.01	neutral	0.4	neutral	2.78	neutral	0.02	neutral	0.12	neutral_impact	-0.5	0.77	neutral	0.94	neutral	-0.57	0.15	neutral	0.27	0.45	0.14	neutral	0.05	neutral	0.18	neutral	0.21	neutral	6	0.59	neutral	0.7	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.18	medium_impact	-1.63	low_impact	0.46	0.8	19.81	23.12	0.5	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3829	3829	C	G	MI.11839	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	523	175	L	V	Ctc/Gtc	-5.52	0	0	benign	0.06	neutral	0.5	neutral	2.76	neutral	-0.67	neutral	-0.52	low_impact	0.92	0.9	neutral	0.94	neutral	0.25	5.19	deleterious	0.27	0.45	0.25	neutral	0.2	neutral	0.26	neutral	0.36	neutral	3	0.44	neutral	0.72	deleterious	-6	neutral	0.15	neutral	0.37	medium_impact	0.28	medium_impact	-0.39	medium_impact	0.62	0.8	19.81	23.12	0.44	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9082	9082	C	A	MI.1184	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	556	186	L	I	Ctt/Att	-1.49	0	0	possibly_damaging	0.51	neutral	0.4	neutral	4.3	neutral	-0.7	neutral	-0.42	neutral_impact	0.22	0.91	neutral	0.95	neutral	1.42	12.88	neutral	0.42	0.65	0.33	neutral	0.26	neutral	0.17	neutral	0.46	neutral	1	0.58	neutral	0.45	neutral	-3	neutral	0.50	deleterious	-0.77	medium_impact	0.19	medium_impact	-0.91	medium_impact	0.62	0.9	28.32	18.04	0.48	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3830	3830	T	C	MI.11840	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	524	175	L	P	cTc/cCc	-2.77	0	0	possibly_damaging	0.84	neutral	0.21	neutral	2.61	deleterious	-3.51	deleterious	-4.89	medium_impact	2.67	0.62	neutral	0.4	neutral	3.56	23.10	deleterious	0.04	0.35	0.51	disease	0.77	disease	0.68	disease	0.72	disease	4	0.9	neutral	0.19	neutral	0	NA	0.71	deleterious	-1.43	low_impact	-0.05	medium_impact	1.14	medium_impact	0.33	0.8	19.81	23.12	0.33	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3830	3830	T	A	MI.11841	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	524	175	L	H	cTc/cAc	-2.77	0	0	possibly_damaging	0.88	neutral	0.54	neutral	2.61	deleterious	-4.06	deleterious	-4.95	high_impact	3.56	0.72	neutral	0.51	neutral	3.97	23.60	deleterious	0.05	0.35	0.64	disease	0.58	disease	0.64	disease	0.68	disease	4	0.87	neutral	0.33	neutral	1	deleterious	0.71	deleterious	-1.56	low_impact	0.31	medium_impact	1.92	medium_impact	0.26	0.8	19.81	23.12	0.31	N	0.82	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3830	3830	T	G	MI.11842	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	524	175	L	R	cTc/cGc	-2.77	0	0	possibly_damaging	0.78	neutral	0.35	neutral	2.63	deleterious	-3.1	deleterious	-4.5	medium_impact	3.22	0.68	neutral	0.47	neutral	2.57	19.90	deleterious	0.03	0.35	0.55	disease	0.77	disease	0.67	disease	0.72	disease	4	0.8	neutral	0.29	neutral	0	NA	0.66	deleterious	-1.27	low_impact	0.12	medium_impact	1.62	medium_impact	0.28	0.8	19.81	23.12	0.33	N	0.92	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3832	3832	C	G	MI.11843	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	526	176	L	V	Ctg/Gtg	-9.89	0	0	benign	0.32	neutral	0.5	neutral	2.72	neutral	-0.85	neutral	-1.03	low_impact	0.93	0.87	neutral	0.98	neutral	2.07	16.68	deleterious	0.23	0.45	0.18	neutral	0.13	neutral	0.27	neutral	0.3	neutral	4	0.41	neutral	0.59	deleterious	-6	neutral	0.21	neutral	-0.44	medium_impact	0.28	medium_impact	-0.38	medium_impact	0.50	0.8	27.36	28.35	0.44	N	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3832	3832	C	A	MI.11844	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	526	176	L	M	Ctg/Atg	-9.89	0	0	probably_damaging	0.9	neutral	0.22	neutral	2.61	neutral	-2.91	neutral	-0.88	low_impact	1.92	0.89	neutral	0.93	neutral	2.63	20.40	deleterious	0.23	0.45	0.34	neutral	0.13	neutral	0.26	neutral	0.31	neutral	4	0.94	neutral	0.16	neutral	-2	neutral	0.58	deleterious	-1.65	low_impact	-0.03	medium_impact	0.49	medium_impact	0.34	0.8	27.36	28.35	0.55	P	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3833	3833	T	G	MI.11845	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	527	176	L	R	cTg/cGg	-5.75	0	0	probably_damaging	0.9	neutral	0.32	neutral	2.57	deleterious	-3.64	deleterious	-4.05	high_impact	3.72	0.73	neutral	0.47	neutral	4.19	23.80	deleterious	0.02	0.35	0.47	neutral	0.66	disease	0.68	disease	0.68	disease	4	0.92	neutral	0.21	neutral	2	deleterious	0.71	deleterious	-1.65	low_impact	0.09	medium_impact	2.06	high_impact	0.25	0.8	27.36	28.35	0.43	N	0.89	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3833	3833	T	A	MI.11846	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	527	176	L	Q	cTg/cAg	-5.75	0	0	probably_damaging	0.93	neutral	0.36	neutral	2.57	deleterious	-4	deleterious	-3.98	high_impact	3.72	0.74	neutral	0.52	neutral	4.19	23.80	deleterious	0.03	0.35	0.48	neutral	0.43	neutral	0.53	disease	0.46	neutral	1	0.93	neutral	0.22	neutral	2	deleterious	0.66	deleterious	-1.81	low_impact	0.14	medium_impact	2.06	high_impact	0.33	0.8	27.36	28.35	0.48	N	0.83	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	T3833A	PEG	+	-	Reported	1	.	P	P	neutral
chrM	3833	3833	T	C	MI.11847	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	527	176	L	P	cTg/cCg	-5.75	0	0	probably_damaging	0.93	neutral	0.2	neutral	2.56	deleterious	-3.39	deleterious	-4.64	medium_impact	3.17	0.68	neutral	0.39	neutral	3.91	23.50	deleterious	0.02	0.35	0.39	neutral	0.68	disease	0.68	disease	0.68	disease	4	0.95	neutral	0.14	neutral	1	deleterious	0.69	deleterious	-1.81	low_impact	-0.06	medium_impact	1.58	medium_impact	0.28	0.8	27.36	28.35	0.37	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3835	3835	C	G	MI.11848	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	529	177	P	A	Cca/Gca	-8.74	0	0	possibly_damaging	0.9	neutral	0.51	neutral	2.82	neutral	-1.73	deleterious	-4.61	medium_impact	2.7	0.8	neutral	0.21	damaging	3.05	22.40	deleterious	0.22	0.45	0.2	neutral	0.37	neutral	0.49	neutral	0.42	neutral	2	0.89	neutral	0.31	neutral	0	NA	0.63	deleterious	-1.65	low_impact	0.29	medium_impact	1.17	medium_impact	0.75	0.85	19.18	20.15	0.26	N	0.64	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3835	3835	C	T	MI.11849	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	529	177	P	S	Cca/Tca	-8.74	0	0	possibly_damaging	0.52	neutral	0.45	neutral	2.8	neutral	-2.46	deleterious	-4.24	low_impact	1.62	0.84	neutral	0.84	neutral	2.64	20.50	deleterious	0.28	0.45	0.21	neutral	0.28	neutral	0.37	neutral	0.41	neutral	2	0.55	neutral	0.47	neutral	-3	neutral	0.42	neutral	-0.78	medium_impact	0.23	medium_impact	0.23	medium_impact	0.23	0.8	19.18	20.15	0.35	N	0.33	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9083	9083	T	C	MI.1185	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	557	186	L	P	cTt/cCt	-1.49	0	0	benign	0.01	neutral	0.3	neutral	4.25	deleterious	-3.76	neutral	1.35	neutral_impact	-1.4	0.92	neutral	0.96	neutral	-0.76	0.05	neutral	0.16	0.65	0.47	neutral	0.15	neutral	0.29	neutral	0.23	neutral	6	0.69	neutral	0.65	deleterious	-6	neutral	0.18	neutral	1.14	medium_impact	0.08	medium_impact	-2.3	low_impact	0.56	0.9	28.32	18.04	0.38	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3835	3835	C	A	MI.11850	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	529	177	P	T	Cca/Aca	-8.74	0	0	probably_damaging	0.94	neutral	0.42	neutral	2.78	neutral	-2.31	deleterious	-4.4	medium_impact	1.97	0.87	neutral	0.86	neutral	2.54	19.71	deleterious	0.22	0.45	0.19	neutral	0.38	neutral	0.38	neutral	0.41	neutral	2	0.94	neutral	0.24	neutral	1	deleterious	0.64	deleterious	-1.87	low_impact	0.2	medium_impact	0.53	medium_impact	0.73	0.85	19.18	20.15	0.4	N	0.41	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3836	3836	C	A	MI.11851	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	530	177	P	Q	cCa/cAa	-0.01	0	0	probably_damaging	0.98	neutral	0.33	neutral	2.76	neutral	-2.88	deleterious	-4.96	high_impact	3.71	0.76	neutral	0.11	damaging	4.04	23.70	deleterious	0.12	0.4	0.27	neutral	0.56	disease	0.56	disease	0.6	disease	2	0.99	deleterious	0.18	neutral	2	deleterious	0.67	deleterious	-2.34	low_impact	0.1	medium_impact	2.05	high_impact	0.41	0.8	19.18	20.15	0.35	N	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3836	3836	C	G	MI.11852	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	530	177	P	R	cCa/cGa	-0.01	0	0	probably_damaging	0.98	neutral	0.34	neutral	2.81	deleterious	-3.16	deleterious	-5.75	high_impact	3.51	0.7	neutral	0.1	damaging	3.56	23.10	deleterious	0.08	0.35	0.25	neutral	0.7	disease	0.67	disease	0.65	disease	3	0.99	deleterious	0.18	neutral	2	deleterious	0.71	deleterious	-2.34	low_impact	0.11	medium_impact	1.88	medium_impact	0.47	0.8	19.18	20.15	0.28	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3836	3836	C	T	MI.11853	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	530	177	P	L	cCa/cTa	-0.01	0	0	probably_damaging	0.98	neutral	0.73	neutral	2.8	neutral	-1.18	deleterious	-6.27	low_impact	1.58	0.74	neutral	0.1	damaging	4.41	24.10	deleterious	0.13	0.4	0.15	neutral	0.53	disease	0.35	neutral	0.22	neutral	6	0.98	neutral	0.38	neutral	-2	neutral	0.66	deleterious	-2.34	low_impact	0.52	medium_impact	0.19	medium_impact	0.64	0.8	19.18	20.15	0.19	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3838	3838	T	G	MI.11854	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	532	178	S	A	Tca/Gca	-5.07	0	0	benign	0.02	neutral	0.56	neutral	2.81	neutral	0.07	neutral	-0.05	neutral_impact	0.71	0.85	neutral	0.98	neutral	-0.94	0.02	neutral	0.32	0.5	0.15	neutral	0.15	neutral	0.29	neutral	0.24	neutral	5	0.42	neutral	0.77	deleterious	-6	neutral	0.13	neutral	0.84	medium_impact	0.33	medium_impact	-0.57	medium_impact	0.57	0.8	22.01	19.27	0.33	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3838	3838	T	C	MI.11855	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	532	178	S	P	Tca/Cca	-5.07	0	0	possibly_damaging	0.74	neutral	0.3	neutral	2.72	neutral	-2.06	deleterious	-2.78	medium_impact	2.08	0.78	neutral	0.37	neutral	2.09	16.80	deleterious	0.07	0.35	0.48	neutral	0.83	disease	0.56	disease	0.67	disease	3	0.8	neutral	0.28	neutral	0	NA	0.60	deleterious	-1.18	low_impact	0.07	medium_impact	0.63	medium_impact	0.38	0.8	22.01	19.27	0.4	N	0.55	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3838	3838	T	A	MI.11856	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	532	178	S	T	Tca/Aca	-5.07	0	0	benign	0.03	neutral	0.39	neutral	2.78	neutral	-0.35	neutral	-0.83	neutral_impact	0.75	0.8	neutral	0.99	neutral	-0.03	2.33	deleterious	0.26	0.45	0.18	neutral	0.21	neutral	0.28	neutral	0.36	neutral	3	0.59	neutral	0.68	deleterious	-6	neutral	0.13	neutral	0.67	medium_impact	0.17	medium_impact	-0.53	medium_impact	0.57	0.8	22.01	19.27	0.44	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3839	3839	C	G	MI.11857	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	533	178	S	W	tCa/tGa	-2.54	0	0	probably_damaging	0.92	neutral	0.34	neutral	2.7	deleterious	-3.77	deleterious	-4.3	medium_impact	2.73	0.73	neutral	0.39	neutral	2.67	20.60	deleterious	0.07	0.35	0.7	disease	0.82	disease	0.53	disease	0.68	disease	4	0.93	neutral	0.21	neutral	1	deleterious	0.73	deleterious	-1.75	low_impact	0.11	medium_impact	1.2	medium_impact	0.17	0.8	22.01	19.27	0.3	N	0.68	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3839	3839	C	T	MI.11858	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	533	178	S	L	tCa/tTa	-2.54	0	0	benign	0.35	neutral	0.78	neutral	2.81	neutral	0.06	deleterious	-3	neutral_impact	-0.06	0.89	neutral	0.88	neutral	1.57	13.66	neutral	0.11	0.4	0.14	neutral	0.55	disease	0.32	neutral	0.24	neutral	5	0.24	neutral	0.72	deleterious	-6	neutral	0.24	neutral	-0.5	medium_impact	0.58	medium_impact	-1.24	low_impact	0.44	0.8	22.01	19.27	0.26	N	0.64	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3841	3841	T	C	MI.11859	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	535	179	W	R	Tga/Cga	-5.52	0	0	probably_damaging	1	neutral	0.22	neutral	2.79	neutral	-2.28	deleterious	-12.54	high_impact	4.03	0.73	neutral	0.09	damaging	3.55	23.10	deleterious	0.06	0.35	0.36	neutral	0.81	disease	0.77	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	-0.03	medium_impact	2.33	high_impact	0.15	0.8	60.06	10.44	0.48	N	0.98	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9083	9083	T	A	MI.1186	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	557	186	L	H	cTt/cAt	-1.49	0	0	possibly_damaging	0.9	neutral	0.53	neutral	4.22	deleterious	-4.32	neutral	-1.87	low_impact	1.3	0.8	neutral	0.52	neutral	2.95	22.00	deleterious	0.23	0.65	0.75	disease	0.6	disease	0.5	neutral	0.51	disease	0	0.88	neutral	0.32	neutral	-3	neutral	0.76	deleterious	-1.66	low_impact	0.32	medium_impact	0.02	medium_impact	0.52	0.9	28.32	18.04	0.24	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3841	3841	T	G	MI.11860	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	535	179	W	G	Tga/Gga	-5.52	0	0	probably_damaging	1	neutral	0.25	neutral	2.78	neutral	-1.81	deleterious	-11.7	medium_impact	3.22	0.75	neutral	0.11	damaging	3.92	23.50	deleterious	0.08	0.35	0.26	neutral	0.64	disease	0.73	disease	0.67	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.01	medium_impact	1.62	medium_impact	0.15	0.8	60.06	10.44	0.35	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3842	3842	G	C	MI.11861	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	536	179	W	S	tGa/tCa	7.34	1	0	probably_damaging	1	neutral	0.43	neutral	2.82	neutral	-1.23	deleterious	-12.54	medium_impact	2.53	0.75	neutral	0.13	damaging	3.99	23.60	deleterious	0.08	0.35	0.24	neutral	0.71	disease	0.71	disease	0.68	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.21	medium_impact	1.02	medium_impact	0.15	0.8	60.06	10.44	0.47	N	0.99	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3842	3842	G	T	MI.11862	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	536	179	W	L	tGa/tTa	7.34	1	0	probably_damaging	1	neutral	1	neutral	2.99	neutral	0.69	deleterious	-11.46	low_impact	1.77	0.76	neutral	0.14	damaging	4.19	23.80	deleterious	0.11	0.4	0.16	neutral	0.58	disease	0.55	disease	0.26	neutral	5	1	deleterious	0.5	deleterious	-2	neutral	0.68	deleterious	-3.57	low_impact	1.96	high_impact	0.36	medium_impact	0.12	0.8	60.06	10.44	0.4	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3843	3843	A	C	MI.11863	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	537	179	W	C	tgA/tgC	7.11	1	0	probably_damaging	1	neutral	0.14	neutral	2.78	deleterious	-3.13	deleterious	-11.61	medium_impact	3.22	0.74	neutral	0.11	damaging	3.96	23.60	deleterious	0.07	0.35	0.43	neutral	0.76	disease	0.69	disease	0.67	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	-0.17	medium_impact	1.62	medium_impact	0.20	0.8	60.06	10.44	0.53	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3843	3843	A	T	MI.11864	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	537	179	W	C	tgA/tgT	7.11	1	0	probably_damaging	1	neutral	0.14	neutral	2.78	deleterious	-3.13	deleterious	-11.61	medium_impact	3.22	0.74	neutral	0.11	damaging	4.10	23.70	deleterious	0.07	0.35	0.43	neutral	0.76	disease	0.69	disease	0.67	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	-0.17	medium_impact	1.62	medium_impact	0.20	0.8	60.06	10.44	0.54	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3844	3844	C	T	MI.11865	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	538	180	P	S	Ccc/Tcc	0.68	0.99	0	probably_damaging	1	neutral	0.32	neutral	2.65	deleterious	-3.45	deleterious	-7.38	high_impact	3.66	0.72	neutral	0.12	damaging	3.93	23.50	deleterious	0.16	0.45	0.39	neutral	0.6	disease	0.61	disease	0.63	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.09	medium_impact	2.01	high_impact	0.19	0.8	60.69	10.4	0.43	N	0.74	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3844	3844	C	A	MI.11866	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	538	180	P	T	Ccc/Acc	0.68	0.99	0	probably_damaging	1	neutral	0.23	neutral	2.66	neutral	-2.9	deleterious	-7.38	high_impact	4.01	0.66	neutral	0.09	damaging	3.67	23.20	deleterious	0.15	0.4	0.34	neutral	0.61	disease	0.6	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	-0.02	medium_impact	2.31	high_impact	0.52	0.8	60.69	10.4	0.46	N	0.91	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3844	3844	C	G	MI.11867	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	538	180	P	A	Ccc/Gcc	0.68	0.99	0	probably_damaging	1	neutral	0.34	neutral	2.68	neutral	-2.51	deleterious	-7.38	high_impact	3.66	0.71	neutral	0.13	damaging	3.04	22.40	deleterious	0.16	0.45	0.3	neutral	0.52	disease	0.67	disease	0.64	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.70	deleterious	-3.57	low_impact	0.11	medium_impact	2.01	high_impact	0.64	0.8	60.69	10.4	0.46	N	0.78	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3845	3845	C	A	MI.11868	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	539	180	P	H	cCc/cAc	5.5	1	0	probably_damaging	1	neutral	0.26	neutral	2.61	deleterious	-5.05	deleterious	-8.31	high_impact	4.16	0.7	neutral	0.1	damaging	4.16	23.80	deleterious	0.08	0.35	0.62	disease	0.74	disease	0.76	disease	0.69	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.02	medium_impact	2.44	high_impact	0.35	0.8	60.69	10.4	0.67	P	0.69	polymorphism	0.99	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3845	3845	C	G	MI.11869	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	539	180	P	R	cCc/cGc	5.5	1	0	probably_damaging	1	neutral	0.16	neutral	2.62	deleterious	-4.35	deleterious	-8.31	high_impact	4.7	0.76	neutral	0.1	damaging	3.60	23.20	deleterious	0.05	0.35	0.52	disease	0.79	disease	0.78	disease	0.68	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.13	medium_impact	2.92	high_impact	0.43	0.8	60.69	10.4	0.72	P	0.71	polymorphism	0.99	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9083	9083	T	G	MI.1187	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	557	186	L	R	cTt/cGt	-1.49	0	0	possibly_damaging	0.8	neutral	0.34	neutral	4.24	deleterious	-3.67	neutral	-1.55	medium_impact	2	0.82	neutral	0.49	neutral	3.01	22.30	deleterious	0.21	0.65	0.64	disease	0.81	disease	0.57	disease	0.77	disease	5	0.82	neutral	0.27	neutral	0	NA	0.77	deleterious	-1.33	low_impact	0.13	medium_impact	0.62	medium_impact	0.61	0.9	28.32	18.04	0.25	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3845	3845	C	T	MI.11870	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	539	180	P	L	cCc/cTc	5.5	1	0	probably_damaging	1	neutral	1	neutral	2.75	neutral	-1.73	deleterious	-9.24	medium_impact	2.52	0.78	neutral	0.1	damaging	4.36	24.10	deleterious	0.14	0.4	0.18	neutral	0.75	disease	0.62	disease	0.64	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.70	deleterious	-3.57	low_impact	1.96	high_impact	1.01	medium_impact	0.51	0.8	60.69	10.4	0.4	N	1.00	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3847	3847	T	G	MI.11871	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	541	181	L	V	Ttg/Gtg	-20	0	0.04	possibly_damaging	0.86	neutral	0.42	neutral	2.71	neutral	-1.11	deleterious	-2.6	medium_impact	2.52	0.75	neutral	0.17	damaging	3.44	23.00	deleterious	0.34	0.5	0.21	neutral	0.3	neutral	0.46	neutral	0.42	neutral	2	0.85	neutral	0.28	neutral	0	NA	0.58	deleterious	-1.49	low_impact	0.2	medium_impact	1.01	medium_impact	0.57	0.8	25.79	14.55	0.34	N	0.41	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3847	3847	T	A	MI.11872	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	541	181	L	M	Ttg/Atg	-20	0	0.04	possibly_damaging	0.68	neutral	0.29	neutral	2.62	neutral	-2.33	neutral	-1.4	medium_impact	2.37	0.84	neutral	0.77	neutral	2.45	19.14	deleterious	0.29	0.45	0.29	neutral	0.16	neutral	0.32	neutral	0.24	neutral	5	0.77	neutral	0.31	neutral	0	NA	0.43	neutral	-1.06	low_impact	0.06	medium_impact	0.88	medium_impact	0.46	0.8	25.79	14.55	0.43	N	0.11	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3848	3848	T	C	MI.11873	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	542	181	L	S	tTg/tCg	-0.93	0	0	probably_damaging	0.98	neutral	0.23	neutral	2.58	neutral	-2.35	deleterious	-5.29	medium_impact	3.46	0.76	neutral	0.14	damaging	3.77	23.40	deleterious	0.06	0.35	0.34	neutral	0.48	neutral	0.58	disease	0.54	disease	1	0.98	deleterious	0.13	neutral	1	deleterious	0.68	deleterious	-2.34	low_impact	-0.02	medium_impact	1.83	medium_impact	0.32	0.8	25.79	14.55	0.37	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3848	3848	T	G	MI.11874	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	542	181	L	W	tTg/tGg	-0.93	0	0	probably_damaging	0.99	neutral	0.22	neutral	2.52	deleterious	-5.57	deleterious	-5.29	high_impact	4.61	0.74	neutral	0.13	damaging	3.78	23.40	deleterious	0.06	0.35	0.73	disease	0.58	disease	0.62	disease	0.62	disease	2	0.99	deleterious	0.12	neutral	2	deleterious	0.74	deleterious	-2.62	low_impact	-0.03	medium_impact	2.84	high_impact	0.28	0.8	25.79	14.55	0.46	N	0.90	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3849	3849	G	C	MI.11875	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	543	181	L	F	ttG/ttC	5.5	0.86	0.02	probably_damaging	0.96	neutral	0.82	neutral	2.57	neutral	-2.59	deleterious	-3.52	medium_impact	2.96	0.72	neutral	0.13	damaging	3.45	23.00	deleterious	0.2	0.45	0.42	neutral	0.43	neutral	0.58	disease	0.48	neutral	0	0.95	neutral	0.43	neutral	1	deleterious	0.68	deleterious	-2.05	low_impact	0.64	medium_impact	1.4	medium_impact	0.49	0.8	25.79	14.55	0.4	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3849	3849	G	T	MI.11876	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	543	181	L	F	ttG/ttT	5.5	0.86	0.02	probably_damaging	0.96	neutral	0.82	neutral	2.57	neutral	-2.59	deleterious	-3.52	medium_impact	2.96	0.72	neutral	0.13	damaging	3.64	23.20	deleterious	0.2	0.45	0.42	neutral	0.43	neutral	0.58	disease	0.48	neutral	0	0.95	neutral	0.43	neutral	1	deleterious	0.68	deleterious	-2.05	low_impact	0.64	medium_impact	1.4	medium_impact	0.49	0.8	25.79	14.55	0.41	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3850	3850	G	A	MI.11877	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	544	182	A	T	Gcc/Acc	-1.62	0	0	benign	0.02	neutral	0.41	neutral	2.73	neutral	-2.72	neutral	-2.21	low_impact	1.38	0.81	neutral	0.86	neutral	1.21	11.82	neutral	0.15	0.4	0.33	neutral	0.39	neutral	0.31	neutral	0.45	neutral	1	0.57	neutral	0.7	deleterious	-6	neutral	0.14	neutral	0.84	medium_impact	0.19	medium_impact	0.02	medium_impact	0.62	0.8	24.84	10.67	0.4	N	0.65	polymorphism	1	0.04	rs879213047	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3850	3850	G	C	MI.11878	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	544	182	A	P	Gcc/Ccc	-1.62	0	0	possibly_damaging	0.85	neutral	0.48	neutral	2.66	deleterious	-4.7	deleterious	-3.65	medium_impact	3.31	0.65	neutral	0.38	neutral	2.14	17.11	deleterious	0.04	0.35	0.6	disease	0.77	disease	0.58	disease	0.62	disease	2	0.84	neutral	0.32	neutral	0	NA	0.68	deleterious	-1.46	low_impact	0.26	medium_impact	1.7	medium_impact	0.36	0.8	24.84	10.67	0.38	N	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3850	3850	G	T	MI.11879	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	544	182	A	S	Gcc/Tcc	-1.62	0	0	benign	0.35	neutral	0.44	neutral	2.71	neutral	-2.58	neutral	-1.94	low_impact	1.26	0.82	neutral	0.6	neutral	1.80	14.99	neutral	0.22	0.45	0.28	neutral	0.35	neutral	0.27	neutral	0.43	neutral	1	0.48	neutral	0.55	deleterious	-6	neutral	0.28	neutral	-0.5	medium_impact	0.22	medium_impact	-0.09	medium_impact	0.38	0.8	24.84	10.67	0.39	N	0.45	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9085	9085	C	A	MI.1188	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	559	187	P	T	Ccc/Acc	-20	0	0	benign	0.38	neutral	0.67	neutral	4.48	neutral	2.41	neutral	0.39	neutral_impact	-0.8	0.85	neutral	0.97	neutral	-0.63	0.11	neutral	0.36	0.65	0.28	neutral	0.08	neutral	0.22	neutral	0.27	neutral	5	0.31	neutral	0.65	deleterious	-6	neutral	0.37	neutral	-0.55	medium_impact	0.47	medium_impact	-1.78	low_impact	0.82	0.9	26.11	13.5	0.38	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3851	3851	C	G	MI.11880	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	545	182	A	G	gCc/gGc	0.91	0	0	benign	0	neutral	0.36	neutral	2.68	neutral	-1.39	deleterious	-3.21	medium_impact	2.06	0.76	neutral	0.59	neutral	2.00	16.20	deleterious	0.17	0.45	0.51	disease	0.41	neutral	0.39	neutral	0.32	neutral	4	0.64	neutral	0.68	deleterious	-3	neutral	0.17	neutral	2.07	high_impact	0.14	medium_impact	0.61	medium_impact	0.50	0.8	24.84	10.67	0.43	N	0.70	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3851	3851	C	T	MI.11881	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	545	182	A	V	gCc/gTc	0.91	0	0	benign	0.35	neutral	0.51	neutral	2.81	neutral	-1.71	neutral	-2.45	medium_impact	2.42	0.82	neutral	0.52	neutral	2.61	20.20	deleterious	0.15	0.4	0.18	neutral	0.56	disease	0.43	neutral	0.43	neutral	1	0.41	neutral	0.58	deleterious	-3	neutral	0.28	neutral	-0.5	medium_impact	0.29	medium_impact	0.93	medium_impact	0.62	0.8	24.84	10.67	0.29	N	0.68	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3851	3851	C	A	MI.11882	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	545	182	A	D	gCc/gAc	0.91	0	0	possibly_damaging	0.68	neutral	0.19	neutral	2.66	deleterious	-4.91	deleterious	-4.47	high_impact	3.87	0.72	neutral	0.38	neutral	2.63	20.40	deleterious	0.03	0.35	0.63	disease	0.77	disease	0.64	disease	0.65	disease	3	0.84	neutral	0.26	neutral	1	deleterious	0.57	deleterious	-1.06	low_impact	-0.08	medium_impact	2.19	high_impact	0.31	0.8	24.84	10.67	0.45	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3853	3853	A	C	MI.11883	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	547	183	M	L	Ata/Cta	-8.97	0	0	benign	0.01	neutral	0.88	neutral	3	neutral	2.1	neutral	-1.47	neutral_impact	0.28	0.84	neutral	0.27	damaging	0.38	6.44	deleterious	0.21	0.45	0.14	neutral	0.48	neutral	0.36	neutral	0.32	neutral	4	0.09	neutral	0.94	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	0.76	medium_impact	-0.94	medium_impact	0.31	0.8	52.52	8.77	0.23	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3853	3853	A	G	MI.11884	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	547	183	M	V	Ata/Gta	-8.97	0	0	benign	0.25	neutral	0.58	neutral	2.91	neutral	1.79	neutral	-1.62	low_impact	1.54	0.7	neutral	0.11	damaging	0.89	10.00	deleterious	0.21	0.45	0.12	neutral	0.55	disease	0.44	neutral	0.18	neutral	6	0.31	neutral	0.67	deleterious	-6	neutral	0.25	neutral	-0.3	medium_impact	0.35	medium_impact	0.16	medium_impact	0.31	0.8	52.52	8.77	0.24	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3853	3853	A	T	MI.11885	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	547	183	M	L	Ata/Tta	-8.97	0	0	benign	0.01	neutral	0.88	neutral	3	neutral	2.1	neutral	-1.47	neutral_impact	0.28	0.84	neutral	0.27	damaging	0.53	7.67	deleterious	0.21	0.45	0.14	neutral	0.48	neutral	0.36	neutral	0.32	neutral	4	0.09	neutral	0.94	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	0.76	medium_impact	-0.94	medium_impact	0.31	0.8	52.52	8.77	0.24	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3854	3854	T	A	MI.11886	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	548	183	M	K	aTa/aAa	3.44	0.99	0	benign	0.36	neutral	0.32	neutral	2.76	neutral	-1.63	deleterious	-3.17	high_impact	3.83	0.64	neutral	0.07	damaging	2.11	16.89	deleterious	0.04	0.35	0.39	neutral	0.79	disease	0.67	disease	0.7	disease	4	0.62	neutral	0.48	deleterious	-2	neutral	0.47	deleterious	-0.52	medium_impact	0.09	medium_impact	2.16	high_impact	0.25	0.8	52.52	8.77	0.51	N	0.95	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3854	3854	T	C	MI.11887	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	548	183	M	T	aTa/aCa	3.44	0.99	0	benign	0.02	neutral	0.41	neutral	2.79	neutral	-0.2	neutral	-2.3	medium_impact	2.59	0.8	neutral	0.3	neutral	-0.07	1.95	neutral	0.1	0.4	0.23	neutral	0.56	disease	0.46	neutral	0.17	neutral	7	0.57	neutral	0.7	deleterious	-3	neutral	0.16	neutral	0.84	medium_impact	0.19	medium_impact	1.07	medium_impact	0.22	0.8	52.52	8.77	0.47	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3855	3855	A	C	MI.11888	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	549	183	M	I	atA/atC	4.13	1	0	benign	0.17	neutral	0.43	neutral	2.92	neutral	1.72	neutral	-1.95	low_impact	1.38	0.73	neutral	0.19	damaging	1.50	13.29	neutral	0.21	0.45	0.15	neutral	0.61	disease	0.4	neutral	0.19	neutral	6	0.49	neutral	0.63	deleterious	-6	neutral	0.25	neutral	-0.1	medium_impact	0.21	medium_impact	0.02	medium_impact	0.33	0.8	52.52	8.77	0.51	N	0.81	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3855	3855	A	T	MI.11889	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	549	183	M	I	atA/atT	4.13	1	0	benign	0.17	neutral	0.43	neutral	2.92	neutral	1.72	neutral	-1.95	low_impact	1.38	0.73	neutral	0.19	damaging	1.55	13.59	neutral	0.21	0.45	0.15	neutral	0.61	disease	0.4	neutral	0.19	neutral	6	0.49	neutral	0.63	deleterious	-6	neutral	0.25	neutral	-0.1	medium_impact	0.21	medium_impact	0.02	medium_impact	0.33	0.8	52.52	8.77	0.52	N	0.81	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9085	9085	C	G	MI.1189	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	559	187	P	A	Ccc/Gcc	-20	0	0	benign	0.18	neutral	0.61	neutral	4.47	neutral	2.22	neutral	-0.64	neutral_impact	-0.54	0.85	neutral	0.94	neutral	-0.47	0.27	neutral	0.34	0.65	0.31	neutral	0.09	neutral	0.3	neutral	0.26	neutral	5	0.27	neutral	0.72	deleterious	-6	neutral	0.28	neutral	-0.13	medium_impact	0.4	medium_impact	-1.56	low_impact	0.83	0.9	26.11	13.5	0.41	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3856	3856	A	C	MI.11890	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	550	184	M	L	Ata/Cta	-0.01	0.96	0	probably_damaging	0.98	neutral	1	neutral	2.86	neutral	2.08	deleterious	-2.78	low_impact	1.66	0.57	damaging	0.08	damaging	3.19	22.70	deleterious	0.21	0.45	0.11	neutral	0.69	disease	0.55	disease	0.22	neutral	6	0.98	deleterious	0.51	deleterious	-2	neutral	0.70	deleterious	-2.34	low_impact	1.96	high_impact	0.26	medium_impact	0.39	0.8	59.43	10.31	0.32	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3856	3856	A	G	MI.11891	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	550	184	M	V	Ata/Gta	-0.01	0.96	0	probably_damaging	0.99	neutral	0.55	neutral	2.89	neutral	2.1	deleterious	-3.72	medium_impact	1.96	0.7	neutral	0.13	damaging	2.65	20.50	deleterious	0.25	0.45	0.13	neutral	0.59	disease	0.46	neutral	0.15	neutral	7	0.99	deleterious	0.28	neutral	1	deleterious	0.69	deleterious	-2.62	low_impact	0.32	medium_impact	0.52	medium_impact	0.40	0.8	59.43	10.31	0.32	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3856	3856	A	T	MI.11892	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	550	184	M	L	Ata/Tta	-0.01	0.96	0	probably_damaging	0.98	neutral	1	neutral	2.86	neutral	2.08	deleterious	-2.78	low_impact	1.66	0.57	damaging	0.08	damaging	3.26	22.80	deleterious	0.21	0.45	0.11	neutral	0.69	disease	0.55	disease	0.22	neutral	6	0.98	deleterious	0.51	deleterious	-2	neutral	0.70	deleterious	-2.34	low_impact	1.96	high_impact	0.26	medium_impact	0.39	0.8	59.43	10.31	0.33	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3857	3857	T	A	MI.11893	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	551	184	M	K	aTa/aAa	8.49	1	0	probably_damaging	1	neutral	0.28	neutral	2.73	neutral	-1.54	deleterious	-5.58	high_impact	3.75	0.63	neutral	0.08	damaging	4.15	23.80	deleterious	0.03	0.35	0.44	neutral	0.82	disease	0.71	disease	0.68	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.05	medium_impact	2.09	high_impact	0.26	0.8	59.43	10.31	0.65	P	1.00	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3857	3857	T	C	MI.11894	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	551	184	M	T	aTa/aCa	8.49	1	0	probably_damaging	1	neutral	0.43	neutral	2.78	neutral	0.05	deleterious	-5.58	medium_impact	3.02	0.72	neutral	0.18	damaging	3.06	22.40	deleterious	0.13	0.4	0.27	neutral	0.73	disease	0.64	disease	0.64	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.21	medium_impact	1.45	medium_impact	0.15	0.8	59.43	10.31	0.54	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3858	3858	A	C	MI.11895	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	552	184	M	I	atA/atC	5.5	1	0	probably_damaging	0.99	neutral	0.55	neutral	2.88	neutral	2.22	deleterious	-3.71	low_impact	1.8	0.63	neutral	0.09	damaging	3.43	23.00	deleterious	0.22	0.45	0.11	neutral	0.72	disease	0.45	neutral	0.15	neutral	7	0.99	deleterious	0.28	neutral	-2	neutral	0.72	deleterious	-2.62	low_impact	0.32	medium_impact	0.38	medium_impact	0.40	0.8	59.43	10.31	0.45	N	0.95	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3858	3858	A	T	MI.11896	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	552	184	M	I	atA/atT	5.5	1	0	probably_damaging	0.99	neutral	0.55	neutral	2.88	neutral	2.22	deleterious	-3.71	low_impact	1.8	0.63	neutral	0.09	damaging	3.45	23.00	deleterious	0.22	0.45	0.11	neutral	0.72	disease	0.45	neutral	0.15	neutral	7	0.99	deleterious	0.28	neutral	-2	neutral	0.72	deleterious	-2.62	low_impact	0.32	medium_impact	0.38	medium_impact	0.40	0.8	59.43	10.31	0.45	N	0.95	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3859	3859	T	C	MI.11897	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	553	185	W	R	Tga/Cga	2.06	1	0	probably_damaging	1	neutral	0.34	neutral	2.58	deleterious	-3.9	deleterious	-13.02	high_impact	4.17	0.56	damaging	0.08	damaging	3.59	23.20	deleterious	0.05	0.35	0.42	neutral	0.89	disease	0.78	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.11	medium_impact	2.45	high_impact	0.12	0.8	59.12	10.43	0.57	P	0.98	polymorphism	1	0.37	.	.	.	.	.	.	COSM6188308	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3859	3859	T	G	MI.11898	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	553	185	W	G	Tga/Gga	2.06	1	0	probably_damaging	1	neutral	0.34	neutral	2.58	deleterious	-4.13	deleterious	-12.09	high_impact	3.97	0.53	damaging	0.08	damaging	3.87	23.50	deleterious	0.06	0.35	0.43	neutral	0.8	disease	0.73	disease	0.67	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.11	medium_impact	2.28	high_impact	0.15	0.8	59.12	10.43	0.48	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3860	3860	G	T	MI.11899	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	554	185	W	L	tGa/tTa	7.34	1	0	probably_damaging	1	neutral	0.8	neutral	2.66	neutral	-1.36	deleterious	-12.09	medium_impact	2.15	0.56	damaging	0.05	damaging	4.27	23.90	deleterious	0.09	0.35	0.14	neutral	0.78	disease	0.68	disease	0.35	neutral	3	1	deleterious	0.4	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.61	medium_impact	0.69	medium_impact	0.10	0.8	59.12	10.43	0.41	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8581	8581	G	C	MI.119	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	55	19	A	P	Gcc/Ccc	-4.73	0	0	probably_damaging	1	deleterious	0	neutral	4.58	neutral	-2.69	neutral	-2.4	neutral_impact	0.46	0.68	neutral	0.39	neutral	3.66	23.20	deleterious	0.13	0.65	0.8	disease	0.82	disease	0.61	disease	0.8	disease	6	1	deleterious	0	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	-0.7	medium_impact	0.64	0.9	29.65	29.28	0.24	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9085	9085	C	T	MI.1190	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	559	187	P	S	Ccc/Tcc	-20	0	0	benign	0.03	neutral	0.51	neutral	4.48	neutral	2.45	neutral	-0.41	neutral_impact	0.12	0.94	neutral	0.96	neutral	0.33	6.00	deleterious	0.49	0.65	0.45	neutral	0.2	neutral	0.26	neutral	0.37	neutral	3	0.45	neutral	0.74	deleterious	-6	neutral	0.15	neutral	0.68	medium_impact	0.3	medium_impact	-1	medium_impact	0.34	0.9	26.11	13.5	0.43	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3860	3860	G	C	MI.11900	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	554	185	W	S	tGa/tCa	7.34	1	0	probably_damaging	1	neutral	0.48	neutral	2.59	deleterious	-3.25	deleterious	-13.02	high_impact	3.83	0.45	damaging	0.09	damaging	4.04	23.70	deleterious	0.07	0.35	0.29	neutral	0.86	disease	0.71	disease	0.69	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.26	medium_impact	2.16	high_impact	0.11	0.8	59.12	10.43	0.54	P	0.99	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3861	3861	A	T	MI.11901	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	555	185	W	C	tgA/tgT	8.95	1	0	probably_damaging	1	neutral	0.21	neutral	2.57	deleterious	-4.77	deleterious	-12.09	high_impact	3.97	0.54	damaging	0.04	damaging	4.12	23.80	deleterious	0.06	0.35	0.24	neutral	0.87	disease	0.75	disease	0.68	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.73	deleterious	-3.57	low_impact	-0.05	medium_impact	2.28	high_impact	0.15	0.8	59.12	10.43	0.55	P	1.00	polymorphism	1	0.16	.	.	.	.	.	.	COSM1138359	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3861	3861	A	C	MI.11902	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	555	185	W	C	tgA/tgC	8.95	1	0	probably_damaging	1	neutral	0.21	neutral	2.57	deleterious	-4.77	deleterious	-12.09	high_impact	3.97	0.54	damaging	0.04	damaging	4.07	23.70	deleterious	0.06	0.35	0.24	neutral	0.87	disease	0.75	disease	0.68	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.73	deleterious	-3.57	low_impact	-0.05	medium_impact	2.28	high_impact	0.15	0.8	59.12	10.43	0.54	P	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3862	3862	T	C	MI.11903	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	556	186	F	L	Ttt/Ctt	1.6	1	0	benign	0.05	neutral	0.77	neutral	2.82	neutral	-0.84	deleterious	-4.49	low_impact	1.7	0.76	neutral	0.14	damaging	4.15	23.80	deleterious	0.19	0.45	0.13	neutral	0.64	disease	0.37	neutral	0.17	neutral	7	0.15	neutral	0.86	deleterious	-6	neutral	0.15	neutral	0.45	medium_impact	0.57	medium_impact	0.3	medium_impact	0.59	0.8	20.44	21.33	0.41	N	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3862	3862	T	G	MI.11904	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	556	186	F	V	Ttt/Gtt	1.6	1	0	possibly_damaging	0.64	neutral	0.54	neutral	2.71	neutral	-1.65	deleterious	-4.9	medium_impact	2.46	0.82	neutral	0.14	damaging	4.12	23.80	deleterious	0.1	0.4	0.19	neutral	0.77	disease	0.43	neutral	0.18	neutral	6	0.61	neutral	0.45	neutral	0	NA	0.50	deleterious	-0.99	medium_impact	0.31	medium_impact	0.96	medium_impact	0.32	0.8	20.44	21.33	0.38	N	0.86	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3862	3862	T	A	MI.11905	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	556	186	F	I	Ttt/Att	1.6	1	0	possibly_damaging	0.52	neutral	0.47	neutral	2.68	neutral	-1.81	deleterious	-4.5	medium_impact	2.41	0.72	neutral	0.11	damaging	4.47	24.20	deleterious	0.14	0.4	0.2	neutral	0.8	disease	0.53	disease	0.45	neutral	1	0.53	neutral	0.48	deleterious	0	NA	0.50	deleterious	-0.78	medium_impact	0.25	medium_impact	0.92	medium_impact	0.46	0.8	20.44	21.33	0.46	N	0.83	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3863	3863	T	A	MI.11906	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	557	186	F	Y	tTt/tAt	7.34	1	0	benign	0.08	neutral	1	neutral	2.69	deleterious	-3	neutral	0.93	low_impact	1.3	0.83	neutral	0.91	neutral	1.66	14.19	neutral	0.15	0.4	0.32	neutral	0.18	neutral	0.34	neutral	0.25	neutral	5	0.08	neutral	0.96	deleterious	-6	neutral	0.16	neutral	0.25	medium_impact	1.96	high_impact	-0.05	medium_impact	0.59	0.8	20.44	21.33	0.54	P	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3863	3863	T	C	MI.11907	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	557	186	F	S	tTt/tCt	7.34	1	0	probably_damaging	0.91	neutral	0.45	neutral	2.63	deleterious	-3.43	deleterious	-5.83	medium_impact	3.44	0.7	neutral	0.11	damaging	4.35	24.10	deleterious	0.05	0.35	0.36	neutral	0.79	disease	0.59	disease	0.66	disease	3	0.9	neutral	0.27	neutral	1	deleterious	0.69	deleterious	-1.69	low_impact	0.23	medium_impact	1.82	medium_impact	0.39	0.8	20.44	21.33	0.54	P	0.98	polymorphism	1	0.20	.	.	.	.	.	.	COSM1138361	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3863	3863	T	G	MI.11908	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	557	186	F	C	tTt/tGt	7.34	1	0	probably_damaging	0.98	neutral	0.2	neutral	2.59	deleterious	-4.4	deleterious	-5.83	high_impact	3.99	0.71	neutral	0.1	damaging	4.13	23.80	deleterious	0.04	0.35	0.55	disease	0.84	disease	0.62	disease	0.68	disease	4	0.98	deleterious	0.11	neutral	2	deleterious	0.74	deleterious	-2.34	low_impact	-0.06	medium_impact	2.3	high_impact	0.20	0.8	20.44	21.33	0.59	P	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3864	3864	T	A	MI.11909	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	558	186	F	L	ttT/ttA	1.83	0.95	0	benign	0.05	neutral	0.77	neutral	2.82	neutral	-0.84	deleterious	-4.49	low_impact	1.7	0.76	neutral	0.14	damaging	4.45	24.20	deleterious	0.19	0.45	0.13	neutral	0.64	disease	0.37	neutral	0.17	neutral	7	0.15	neutral	0.86	deleterious	-6	neutral	0.15	neutral	0.45	medium_impact	0.57	medium_impact	0.3	medium_impact	0.59	0.8	20.44	21.33	0.34	N	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9086	9086	C	T	MI.1191	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	560	187	P	L	cCc/cTc	-4.73	0	0	possibly_damaging	0.6	neutral	0.74	neutral	4.55	neutral	3.21	neutral	-0.78	neutral_impact	-1.24	0.86	neutral	0.93	neutral	2.61	20.20	deleterious	0.4	0.65	0.22	neutral	0.36	neutral	0.29	neutral	0.45	neutral	1	0.52	neutral	0.57	deleterious	-3	neutral	0.46	deleterious	-0.92	medium_impact	0.55	medium_impact	-2.16	low_impact	0.85	0.9	26.11	13.5	0.27	N	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3864	3864	T	G	MI.11910	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	558	186	F	L	ttT/ttG	1.83	0.95	0	benign	0.05	neutral	0.77	neutral	2.82	neutral	-0.84	deleterious	-4.49	low_impact	1.7	0.76	neutral	0.14	damaging	4.34	24.00	deleterious	0.19	0.45	0.13	neutral	0.64	disease	0.37	neutral	0.17	neutral	7	0.15	neutral	0.86	deleterious	-6	neutral	0.15	neutral	0.45	medium_impact	0.57	medium_impact	0.3	medium_impact	0.59	0.8	20.44	21.33	0.34	N	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3865	3865	A	C	MI.11911	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	559	187	I	L	Atc/Ctc	-2.77	0	0	benign	0.17	neutral	1	neutral	2.55	neutral	-1.61	neutral	-1.68	medium_impact	2.73	0.72	neutral	0.39	neutral	1.92	15.72	deleterious	0.21	0.45	0.33	neutral	0.54	disease	0.53	disease	0.58	disease	2	0.17	neutral	0.92	deleterious	-3	neutral	0.22	neutral	-0.1	medium_impact	1.96	high_impact	1.2	medium_impact	0.41	0.8	23.9	24.14	0.27	N	0.67	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3865	3865	A	G	MI.11912	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	559	187	I	V	Atc/Gtc	-2.77	0	0	benign	0.01	neutral	0.33	neutral	2.64	neutral	-1.18	neutral	-0.38	neutral_impact	0.58	0.84	neutral	0.84	neutral	-0.16	1.33	neutral	0.4	0.5	0.2	neutral	0.11	neutral	0.31	neutral	0.26	neutral	5	0.66	neutral	0.66	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.1	medium_impact	-0.68	medium_impact	0.31	0.8	23.9	24.14	0.43	N	0.12	polymorphism	1	0.02	rs878989562	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3865	3865	A	T	MI.11913	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	559	187	I	F	Atc/Ttc	-2.77	0	0	possibly_damaging	0.83	neutral	0.54	neutral	2.47	neutral	-2.97	deleterious	-3.45	medium_impact	2.52	0.69	neutral	0.37	neutral	3.43	23.00	deleterious	0.13	0.4	0.33	neutral	0.67	disease	0.58	disease	0.65	disease	3	0.81	neutral	0.36	neutral	0	NA	0.61	deleterious	-1.4	low_impact	0.31	medium_impact	1.01	medium_impact	0.41	0.8	23.9	24.14	0.32	N	0.77	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3866	3866	T	A	MI.11914	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	560	187	I	N	aTc/aAc	2.06	0.83	0.01	possibly_damaging	0.78	neutral	0.19	neutral	2.43	deleterious	-5.22	deleterious	-5.62	high_impact	3.88	0.72	neutral	0.4	neutral	4.30	24.00	deleterious	0.08	0.35	0.76	disease	0.78	disease	0.6	disease	0.67	disease	3	0.88	neutral	0.21	neutral	1	deleterious	0.67	deleterious	-1.27	low_impact	-0.08	medium_impact	2.2	high_impact	0.26	0.8	23.9	24.14	0.48	N	0.95	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3866	3866	T	G	MI.11915	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	560	187	I	S	aTc/aGc	2.06	0.83	0.01	possibly_damaging	0.48	neutral	0.32	neutral	2.47	deleterious	-3.87	deleterious	-4.68	medium_impact	1.99	0.69	neutral	0.44	neutral	2.69	20.70	deleterious	0.03	0.35	0.49	neutral	0.6	disease	0.42	neutral	0.21	neutral	6	0.65	neutral	0.42	neutral	0	NA	0.42	neutral	-0.72	medium_impact	0.09	medium_impact	0.55	medium_impact	0.15	0.8	23.9	24.14	0.45	N	0.83	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3866	3866	T	C	MI.11916	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	560	187	I	T	aTc/aCc	2.06	0.83	0.01	benign	0.03	neutral	0.27	neutral	2.47	deleterious	-3.15	deleterious	-3.33	low_impact	1.49	0.81	neutral	0.83	neutral	0.44	6.95	deleterious	0.07	0.35	0.53	disease	0.42	neutral	0.39	neutral	0.35	neutral	3	0.72	neutral	0.62	deleterious	-6	neutral	0.18	neutral	0.67	medium_impact	0.03	medium_impact	0.11	medium_impact	0.21	0.8	23.9	24.14	0.51	N	0.39	polymorphism	1	0.12	rs200479541	.	.	.	.	.	.	CPD	9.94	T3866C	LHON +limb claudication	.	.	Reported	3	N	P	N,P	neutral
chrM	3867	3867	C	A	MI.11917	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	561	187	I	M	atC/atA	3.67	0.89	0	possibly_damaging	0.87	neutral	0.38	neutral	2.45	deleterious	-3.51	neutral	-2.33	medium_impact	2.66	0.7	neutral	0.45	neutral	3.53	23.10	deleterious	0.21	0.45	0.57	disease	0.47	neutral	0.5	neutral	0.58	disease	2	0.87	neutral	0.26	neutral	0	NA	0.62	deleterious	-1.53	low_impact	0.16	medium_impact	1.14	medium_impact	0.37	0.8	23.9	24.14	0.46	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3867	3867	C	G	MI.11918	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	561	187	I	M	atC/atG	3.67	0.89	0	possibly_damaging	0.87	neutral	0.38	neutral	2.45	deleterious	-3.51	neutral	-2.33	medium_impact	2.66	0.7	neutral	0.45	neutral	3.13	22.60	deleterious	0.21	0.45	0.57	disease	0.47	neutral	0.5	neutral	0.58	disease	2	0.87	neutral	0.26	neutral	0	NA	0.62	deleterious	-1.53	low_impact	0.16	medium_impact	1.14	medium_impact	0.37	0.8	23.9	24.14	0.46	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3868	3868	T	A	MI.11919	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	562	188	S	T	Tcc/Acc	-3	0	0	probably_damaging	1	neutral	0.39	neutral	2.61	neutral	-1.3	deleterious	-2.77	medium_impact	2.71	0.59	damaging	0.05	damaging	3.76	23.40	deleterious	0.22	0.45	0.27	neutral	0.54	disease	0.56	disease	0.23	neutral	5	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.17	medium_impact	1.18	medium_impact	0.59	0.8	59.12	10.46	0.27	N	0.68	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9086	9086	C	G	MI.1192	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	560	187	P	R	cCc/cGc	-4.73	0	0	possibly_damaging	0.77	neutral	0.31	neutral	4.43	neutral	1.54	neutral	-1.77	low_impact	1.66	0.89	neutral	0.44	neutral	2.26	17.90	deleterious	0.31	0.65	0.62	disease	0.56	disease	0.65	disease	0.7	disease	4	0.81	neutral	0.27	neutral	-3	neutral	0.63	deleterious	-1.25	low_impact	0.1	medium_impact	0.33	medium_impact	0.72	0.9	26.11	13.5	0.34	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3868	3868	T	G	MI.11920	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	562	188	S	A	Tcc/Gcc	-3	0	0	probably_damaging	1	neutral	0.54	neutral	2.72	neutral	0.73	deleterious	-2.77	medium_impact	2.45	0.6	neutral	0.11	damaging	3.65	23.20	deleterious	0.3	0.45	0.16	neutral	0.51	disease	0.62	disease	0.62	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.69	deleterious	-3.57	low_impact	0.31	medium_impact	0.95	medium_impact	0.55	0.8	59.12	10.46	0.23	N	0.46	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3868	3868	T	C	MI.11921	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	562	188	S	P	Tcc/Ccc	-3	0	0	probably_damaging	1	neutral	0.22	neutral	2.56	deleterious	-3.85	deleterious	-4.63	high_impact	3.88	0.65	neutral	0.04	damaging	3.96	23.60	deleterious	0.04	0.35	0.5	disease	0.75	disease	0.75	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	-0.03	medium_impact	2.2	high_impact	0.26	0.8	59.12	10.46	0.36	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3869	3869	C	T	MI.11922	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	563	188	S	F	tCc/tTc	7.34	1	0	probably_damaging	1	neutral	0.72	neutral	2.57	neutral	-2.21	deleterious	-5.53	high_impact	4.33	0.61	neutral	0.02	damaging	4.29	24.00	deleterious	0.04	0.35	0.47	neutral	0.79	disease	0.62	disease	0.65	disease	3	1	deleterious	0.36	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.51	medium_impact	2.59	high_impact	0.15	0.8	59.12	10.46	0.53	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3869	3869	C	A	MI.11923	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	563	188	S	Y	tCc/tAc	7.34	1	0	probably_damaging	1	neutral	1	neutral	2.56	deleterious	-3.04	deleterious	-5.54	high_impact	4.68	0.61	neutral	0.04	damaging	4.11	23.70	deleterious	0.04	0.35	0.52	disease	0.78	disease	0.66	disease	0.67	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.57	low_impact	1.96	high_impact	2.9	high_impact	0.25	0.8	59.12	10.46	0.59	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3869	3869	C	G	MI.11924	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	563	188	S	C	tCc/tGc	7.34	1	0	probably_damaging	1	neutral	0.18	neutral	2.56	neutral	-2.39	deleterious	-4.6	medium_impact	2.72	0.67	neutral	0.07	damaging	3.57	23.10	deleterious	0.06	0.35	0.43	neutral	0.69	disease	0.56	disease	0.5	disease	0	1	deleterious	0.09	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	-0.09	medium_impact	1.19	medium_impact	0.34	0.8	59.12	10.46	0.56	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3871	3871	A	C	MI.11925	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	565	189	T	P	Aca/Cca	-10.81	0	0	probably_damaging	1	neutral	0.21	neutral	2.67	neutral	-2.94	deleterious	-5.52	high_impact	3.94	0.62	neutral	0.07	damaging	3.52	23.10	deleterious	0.04	0.35	0.54	disease	0.84	disease	0.73	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	-0.05	medium_impact	2.25	high_impact	0.44	0.8	60.06	10.25	0.31	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3871	3871	A	T	MI.11926	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	565	189	T	S	Aca/Tca	-10.81	0	0	probably_damaging	1	neutral	0.41	neutral	2.79	neutral	0.38	deleterious	-3.68	low_impact	1.88	0.6	damaging	0.09	damaging	3.40	23.00	deleterious	0.32	0.5	0.19	neutral	0.52	disease	0.36	neutral	0.18	neutral	6	1	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-3.57	low_impact	0.19	medium_impact	0.45	medium_impact	0.68	0.85	60.06	10.25	0.28	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3871	3871	A	G	MI.11927	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	565	189	T	A	Aca/Gca	-10.81	0	0	probably_damaging	1	neutral	0.53	neutral	2.82	neutral	0.86	deleterious	-4.61	low_impact	1.86	0.66	neutral	0.09	damaging	3.48	23.10	deleterious	0.25	0.45	0.18	neutral	0.53	disease	0.4	neutral	0.17	neutral	7	1	deleterious	0.27	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.3	medium_impact	0.44	medium_impact	0.50	0.8	60.06	10.25	0.25	N	0.65	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3872	3872	C	A	MI.11928	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	566	189	T	K	aCa/aAa	8.49	1	0	probably_damaging	1	neutral	0.29	neutral	2.73	neutral	-2.29	deleterious	-5.54	medium_impact	3.13	0.64	neutral	0.05	damaging	4.45	24.20	deleterious	0.06	0.35	0.41	neutral	0.85	disease	0.7	disease	0.69	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.06	medium_impact	1.55	medium_impact	0.39	0.8	60.06	10.25	0.55	P	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3872	3872	C	T	MI.11929	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	566	189	T	M	aCa/aTa	8.49	1	0	probably_damaging	1	neutral	0.24	neutral	2.69	neutral	0.14	deleterious	-5.54	low_impact	1.71	0.66	neutral	0.05	damaging	4.07	23.70	deleterious	0.21	0.45	0.21	neutral	0.71	disease	0.41	neutral	0.14	neutral	7	1	deleterious	0.12	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	-0.01	medium_impact	0.31	medium_impact	0.75	0.85	60.06	10.25	0.47	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9086	9086	C	A	MI.1193	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	560	187	P	H	cCc/cAc	-4.73	0	0	possibly_damaging	0.9	neutral	0.48	neutral	4.39	neutral	0.08	neutral	-2.13	low_impact	1.32	0.85	neutral	0.43	neutral	2.86	21.70	deleterious	0.32	0.65	0.53	disease	0.39	neutral	0.58	disease	0.52	disease	0	0.9	neutral	0.29	neutral	-3	neutral	0.66	deleterious	-1.66	low_impact	0.27	medium_impact	0.03	medium_impact	0.67	0.9	26.11	13.5	0.25	N	0.86	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3874	3874	C	A	MI.11930	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	568	190	L	M	Cta/Ata	-4.38	0	0	probably_damaging	1	neutral	0.72	neutral	1.98	deleterious	-4.07	neutral	-1.86	medium_impact	2.84	0.76	neutral	0.12	damaging	3.80	23.40	deleterious	0.28	0.45	0.47	neutral	0.55	disease	0.53	disease	0.25	neutral	5	1	deleterious	0.36	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.51	medium_impact	1.29	medium_impact	0.64	0.8	59.75	10.55	0.21	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3874	3874	C	G	MI.11931	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	568	190	L	V	Cta/Gta	-4.38	0	0	probably_damaging	1	neutral	0.59	neutral	2.1	neutral	-2.59	deleterious	-2.78	medium_impact	2.77	0.68	neutral	0.09	damaging	3.46	23.00	deleterious	0.25	0.45	0.33	neutral	0.59	disease	0.55	disease	0.49	neutral	0	1	deleterious	0.3	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.36	medium_impact	1.23	medium_impact	0.47	0.8	59.75	10.55	0.2	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3875	3875	T	G	MI.11932	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	569	190	L	R	cTa/cGa	-0.24	0	0	probably_damaging	1	neutral	0.23	neutral	1.92	deleterious	-6.2	deleterious	-5.58	high_impact	4.76	0.75	neutral	0.07	damaging	4.23	23.90	deleterious	0.04	0.35	0.74	disease	0.89	disease	0.74	disease	0.69	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.02	medium_impact	2.97	high_impact	0.12	0.8	59.75	10.55	0.64	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3875	3875	T	A	MI.11933	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	569	190	L	Q	cTa/cAa	-0.24	0	0	probably_damaging	1	neutral	0.14	neutral	1.92	deleterious	-6.22	deleterious	-5.58	high_impact	4.42	0.73	neutral	0.09	damaging	4.39	24.10	deleterious	0.05	0.35	0.75	disease	0.82	disease	0.63	disease	0.65	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	-0.17	medium_impact	2.67	high_impact	0.22	0.8	59.75	10.55	0.39	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3875	3875	T	C	MI.11934	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	569	190	L	P	cTa/cCa	-0.24	0	0	probably_damaging	1	neutral	0.15	neutral	1.92	deleterious	-6.85	deleterious	-6.51	high_impact	3.96	0.77	neutral	0.08	damaging	3.98	23.60	deleterious	0.04	0.35	0.8	disease	0.81	disease	0.74	disease	0.68	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.15	medium_impact	2.27	high_impact	0.19	0.8	59.75	10.55	0.33	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3877	3877	G	A	MI.11935	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	571	191	A	T	Gca/Aca	-0.01	0.95	0	probably_damaging	1	neutral	0.39	neutral	1.76	deleterious	-4.57	deleterious	-3.69	high_impact	4.54	0.61	neutral	0.03	damaging	4.27	24.00	deleterious	0.1	0.4	0.43	neutral	0.8	disease	0.66	disease	0.66	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.17	medium_impact	2.78	high_impact	0.69	0.85	60.06	10.33	0.56	P	0.70	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3877	3877	G	T	MI.11936	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	571	191	A	S	Gca/Tca	-0.01	0.95	0	probably_damaging	1	neutral	0.41	neutral	1.78	deleterious	-4.1	deleterious	-2.78	medium_impact	3.44	0.6	neutral	0.04	damaging	3.75	23.30	deleterious	0.16	0.45	0.48	neutral	0.8	disease	0.59	disease	0.65	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.82	deleterious	-3.57	low_impact	0.19	medium_impact	1.82	medium_impact	0.48	0.8	60.06	10.33	0.39	N	0.93	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3877	3877	G	C	MI.11937	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	571	191	A	P	Gca/Cca	-0.01	0.95	0	probably_damaging	1	neutral	0.21	neutral	1.72	deleterious	-5.95	deleterious	-4.63	high_impact	4.08	0.65	neutral	0.03	damaging	3.87	23.50	deleterious	0.03	0.35	0.71	disease	0.85	disease	0.74	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.05	medium_impact	2.38	high_impact	0.49	0.8	60.06	10.33	0.48	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3878	3878	C	T	MI.11938	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	572	191	A	V	gCa/gTa	8.95	1	0	probably_damaging	1	neutral	0.5	neutral	1.75	deleterious	-4.79	deleterious	-3.66	high_impact	3.68	0.7	neutral	0.03	damaging	4.47	24.20	deleterious	0.08	0.35	0.3	neutral	0.81	disease	0.6	disease	0.66	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.28	medium_impact	2.03	high_impact	0.74	0.85	60.06	10.33	0.56	P	0.72	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3878	3878	C	A	MI.11939	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	572	191	A	E	gCa/gAa	8.95	1	0	probably_damaging	1	neutral	0.27	neutral	1.73	deleterious	-5.49	deleterious	-4.63	high_impact	4.34	0.69	neutral	0.03	damaging	4.55	24.40	deleterious	0.03	0.35	0.58	disease	0.87	disease	0.74	disease	0.7	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.03	medium_impact	2.6	high_impact	0.20	0.8	60.06	10.33	0.65	P	0.96	polymorphism	0.99	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9088	9088	T	C	MI.1194	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	562	188	S	P	Tct/Cct	-4.04	0	0	benign	0.12	neutral	0.11	neutral	4.3	neutral	-2.54	neutral	-0.81	neutral_impact	0.78	0.9	neutral	0.56	neutral	2.19	17.46	deleterious	0.24	0.65	0.63	disease	0.78	disease	0.64	disease	0.76	disease	5	0.88	neutral	0.5	deleterious	-6	neutral	0.37	neutral	0.07	medium_impact	-0.22	medium_impact	-0.43	medium_impact	0.74	0.9	27.88	19.63	0.34	N	0.18	polymorphism	1	0.02	rs370460521	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3878	3878	C	G	MI.11940	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	572	191	A	G	gCa/gGa	8.95	1	0	probably_damaging	1	neutral	0.33	neutral	1.75	deleterious	-4.8	deleterious	-3.72	high_impact	3.73	0.67	neutral	0.05	damaging	3.97	23.60	deleterious	0.19	0.45	0.44	neutral	0.77	disease	0.6	disease	0.65	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.1	medium_impact	2.07	high_impact	0.72	0.85	60.06	10.33	0.6	P	0.79	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3880	3880	G	C	MI.11941	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	574	192	E	Q	Gag/Cag	-3	0	0	probably_damaging	1	neutral	0.25	neutral	2.27	deleterious	-3.47	deleterious	-2.79	high_impact	4.54	0.7	neutral	0.17	damaging	3.45	23.00	deleterious	0.15	0.4	0.57	disease	0.77	disease	0.68	disease	0.65	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.01	medium_impact	2.78	high_impact	0.65	0.8	59.43	10.4	0.49	N	0.91	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3880	3880	G	A	MI.11942	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	574	192	E	K	Gag/Aag	-3	0	0	probably_damaging	1	neutral	0.25	neutral	2.29	neutral	-2.25	deleterious	-3.71	high_impact	3.6	0.68	neutral	0.12	damaging	4.54	24.30	deleterious	0.06	0.35	0.52	disease	0.88	disease	0.66	disease	0.68	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.01	medium_impact	1.96	medium_impact	0.77	0.85	59.43	10.4	0.39	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3881	3881	A	C	MI.11943	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	575	192	E	A	gAg/gCg	7.11	1	0	probably_damaging	1	neutral	0.55	neutral	2.28	deleterious	-3.13	deleterious	-5.57	high_impact	4.2	0.71	neutral	0.19	damaging	3.69	23.30	deleterious	0.04	0.35	0.57	disease	0.74	disease	0.66	disease	0.65	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.32	medium_impact	2.48	high_impact	0.33	0.8	59.43	10.4	0.59	P	0.74	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3881	3881	A	G	MI.11944	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	575	192	E	G	gAg/gGg	7.11	1	0	probably_damaging	1	neutral	0.3	neutral	2.24	deleterious	-4.18	deleterious	-6.5	high_impact	4.54	0.69	neutral	0.19	damaging	4.24	23.90	deleterious	0.04	0.35	0.66	disease	0.8	disease	0.7	disease	0.66	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.07	medium_impact	2.78	high_impact	0.21	0.8	59.43	10.4	0.66	P	0.61	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3881	3881	A	T	MI.11945	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	575	192	E	V	gAg/gTg	7.11	1	0	probably_damaging	1	neutral	0.49	neutral	2.27	deleterious	-4.31	deleterious	-6.5	high_impact	3.69	0.75	neutral	0.17	damaging	4.18	23.80	deleterious	0.03	0.35	0.74	disease	0.87	disease	0.71	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.27	medium_impact	2.03	high_impact	0.32	0.8	59.43	10.4	0.63	P	0.83	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3882	3882	G	C	MI.11946	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	576	192	E	D	gaG/gaC	8.49	1	0	probably_damaging	1	neutral	0.2	neutral	2.3	deleterious	-3.58	deleterious	-2.79	high_impact	3.6	0.73	neutral	0.15	damaging	3.75	23.30	deleterious	0.18	0.45	0.36	neutral	0.74	disease	0.64	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.06	medium_impact	1.96	medium_impact	0.60	0.8	59.43	10.4	0.64	P	0.90	polymorphism	0.98	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3882	3882	G	T	MI.11947	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	576	192	E	D	gaG/gaT	8.49	1	0	probably_damaging	1	neutral	0.2	neutral	2.3	deleterious	-3.58	deleterious	-2.79	high_impact	3.6	0.73	neutral	0.15	damaging	3.91	23.50	deleterious	0.18	0.45	0.36	neutral	0.74	disease	0.64	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.06	medium_impact	1.96	medium_impact	0.60	0.8	59.43	10.4	0.64	P	0.90	polymorphism	0.98	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3883	3883	A	G	MI.11948	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	577	193	T	A	Acc/Gcc	0.68	0.99	0	probably_damaging	1	neutral	0.53	neutral	2.61	neutral	-2.19	deleterious	-4.76	medium_impact	3.27	0.61	neutral	0.09	damaging	3.46	23.00	deleterious	0.24	0.45	0.31	neutral	0.63	disease	0.61	disease	0.65	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.3	medium_impact	1.67	medium_impact	0.18	0.8	60.06	10.43	0.39	N	0.65	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3883	3883	A	C	MI.11949	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	577	193	T	P	Acc/Ccc	0.68	0.99	0	probably_damaging	1	neutral	0.2	neutral	2.52	deleterious	-5.07	deleterious	-5.71	high_impact	4.34	0.64	neutral	0.07	damaging	3.50	23.10	deleterious	0.03	0.35	0.63	disease	0.8	disease	0.76	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.06	medium_impact	2.6	high_impact	0.22	0.8	60.06	10.43	0.54	P	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9088	9088	T	A	MI.1195	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	562	188	S	T	Tct/Act	-4.04	0	0	benign	0	neutral	0.39	neutral	4.38	neutral	-0.13	neutral	1.37	neutral_impact	-0.8	0.85	neutral	0.97	neutral	-0.01	2.46	deleterious	0.35	0.65	0.22	neutral	0.11	neutral	0.17	neutral	0.31	neutral	4	0.61	neutral	0.7	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	0.18	medium_impact	-1.78	low_impact	0.70	0.9	27.88	19.63	0.5	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3883	3883	A	T	MI.11950	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	577	193	T	S	Acc/Tcc	0.68	0.99	0	probably_damaging	1	neutral	0.44	neutral	2.58	neutral	-2.89	deleterious	-3.81	medium_impact	2.94	0.55	damaging	0.07	damaging	3.28	22.80	deleterious	0.33	0.5	0.33	neutral	0.71	disease	0.53	disease	0.58	disease	2	1	deleterious	0.22	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.22	medium_impact	1.38	medium_impact	0.42	0.8	60.06	10.43	0.42	N	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3884	3884	C	A	MI.11951	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	578	193	T	N	aCc/aAc	8.49	1	0	probably_damaging	1	neutral	0.31	neutral	2.53	deleterious	-3.98	deleterious	-4.76	medium_impact	3.19	0.6	damaging	0.05	damaging	3.69	23.30	deleterious	0.28	0.45	0.55	disease	0.83	disease	0.64	disease	0.67	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.08	medium_impact	1.6	medium_impact	0.48	0.8	60.06	10.43	0.54	P	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3884	3884	C	T	MI.11952	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	578	193	T	I	aCc/aTc	8.49	1	0	probably_damaging	1	neutral	0.42	neutral	2.6	neutral	-2.26	deleterious	-5.71	medium_impact	3.17	0.67	neutral	0.06	damaging	4.07	23.70	deleterious	0.13	0.4	0.3	neutral	0.86	disease	0.61	disease	0.69	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.2	medium_impact	1.58	medium_impact	0.41	0.8	60.06	10.43	0.5	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3884	3884	C	G	MI.11953	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	578	193	T	S	aCc/aGc	8.49	1	0	probably_damaging	1	neutral	0.44	neutral	2.58	neutral	-2.89	deleterious	-3.81	medium_impact	2.94	0.55	damaging	0.07	damaging	3.55	23.10	deleterious	0.33	0.5	0.33	neutral	0.71	disease	0.53	disease	0.58	disease	2	1	deleterious	0.22	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.22	medium_impact	1.38	medium_impact	0.42	0.8	60.06	10.43	0.55	P	0.89	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3886	3886	A	T	MI.11954	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	580	194	N	Y	Aac/Tac	-12.42	0	0	probably_damaging	1	neutral	1	neutral	2.49	deleterious	-4.32	deleterious	-7.6	high_impact	4.02	0.71	neutral	0.07	damaging	3.81	23.40	deleterious	0.11	0.4	0.65	disease	0.84	disease	0.67	disease	0.68	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.82	deleterious	-3.57	low_impact	1.96	high_impact	2.32	high_impact	0.13	0.8	58.81	10.46	0.25	N	1.00	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3886	3886	A	G	MI.11955	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	580	194	N	D	Aac/Gac	-12.42	0	0	probably_damaging	1	neutral	0.23	neutral	2.58	neutral	-1.66	deleterious	-4.75	high_impact	4.48	0.73	neutral	0.1	damaging	3.96	23.60	deleterious	0.61	0.65	0.35	neutral	0.71	disease	0.65	disease	0.65	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	-0.02	medium_impact	2.72	high_impact	0.24	0.8	58.81	10.46	0.49	N	0.97	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3886	3886	A	C	MI.11956	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	580	194	N	H	Aac/Cac	-12.42	0	0	probably_damaging	1	neutral	0.53	neutral	2.53	neutral	-2.73	deleterious	-4.75	medium_impact	3.16	0.69	neutral	0.07	damaging	3.15	22.60	deleterious	0.41	0.5	0.53	disease	0.76	disease	0.67	disease	0.64	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.3	medium_impact	1.57	medium_impact	0.14	0.8	58.81	10.46	0.23	N	0.97	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3887	3887	A	G	MI.11957	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	581	194	N	S	aAc/aGc	6.65	1	0	probably_damaging	1	neutral	0.55	neutral	2.56	neutral	-2.05	deleterious	-4.75	high_impact	3.85	0.79	neutral	0.12	damaging	3.74	23.30	deleterious	0.53	0.6	0.32	neutral	0.75	disease	0.61	disease	0.64	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.32	medium_impact	2.17	high_impact	0.17	0.8	58.81	10.46	0.53	N	0.90	polymorphism	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3887	3887	A	C	MI.11958	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	581	194	N	T	aAc/aCc	6.65	1	0	probably_damaging	1	neutral	0.51	neutral	2.53	neutral	-2.52	deleterious	-5.69	high_impact	4.48	0.74	neutral	0.11	damaging	3.99	23.60	deleterious	0.29	0.45	0.38	neutral	0.76	disease	0.56	disease	0.64	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.29	medium_impact	2.72	high_impact	0.27	0.8	58.81	10.46	0.55	P	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3887	3887	A	T	MI.11959	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	581	194	N	I	aAc/aTc	6.65	1	0	probably_damaging	1	neutral	0.42	neutral	2.49	deleterious	-3.97	deleterious	-8.55	high_impact	4.13	0.73	neutral	0.09	damaging	4.59	24.40	deleterious	0.1	0.4	0.59	disease	0.87	disease	0.62	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.2	medium_impact	2.42	high_impact	0.14	0.8	58.81	10.46	0.61	P	1.00	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9088	9088	T	G	MI.1196	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	562	188	S	A	Tct/Gct	-4.04	0	0	benign	0	neutral	0.29	neutral	4.39	neutral	-0.07	neutral	0.44	neutral_impact	-0.62	0.97	neutral	0.97	neutral	0.42	6.77	deleterious	0.46	0.65	0.34	neutral	0.15	neutral	0.2	neutral	0.3	neutral	4	0.71	neutral	0.65	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	0.07	medium_impact	-1.63	low_impact	0.76	0.9	27.88	19.63	0.5	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3888	3888	C	G	MI.11960	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	582	194	N	K	aaC/aaG	8.49	1	0	probably_damaging	1	neutral	0.29	neutral	2.61	neutral	-1.34	deleterious	-5.7	high_impact	3.5	0.76	neutral	0.1	damaging	4.07	23.70	deleterious	0.42	0.55	0.26	neutral	0.79	disease	0.61	disease	0.65	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.06	medium_impact	1.87	medium_impact	0.33	0.8	58.81	10.46	0.56	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3888	3888	C	A	MI.11961	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	582	194	N	K	aaC/aaA	8.49	1	0	probably_damaging	1	neutral	0.29	neutral	2.61	neutral	-1.34	deleterious	-5.7	high_impact	3.5	0.76	neutral	0.1	damaging	4.48	24.20	deleterious	0.42	0.55	0.26	neutral	0.79	disease	0.61	disease	0.65	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.06	medium_impact	1.87	medium_impact	0.33	0.8	58.81	10.46	0.56	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3889	3889	C	G	MI.11962	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	583	195	R	G	Cga/Gga	-1.39	0	0	probably_damaging	1	neutral	0.44	neutral	1.63	deleterious	-5.9	deleterious	-6.66	high_impact	4.91	0.75	neutral	0.09	damaging	4.28	24.00	deleterious	0.04	0.35	0.8	disease	0.8	disease	0.76	disease	0.67	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.22	medium_impact	3.1	high_impact	0.12	0.8	59.12	10.38	0.66	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3889	3889	C	T	MI.11963	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	583	195	R	W	Cga/Tga	-1.39	0	0	probably_damaging	1	neutral	0.18	neutral	1.6	deleterious	-8.5	deleterious	-7.61	high_impact	4.56	0.62	neutral	0.06	damaging	5.26	25.70	deleterious	0.05	0.35	0.94	disease	0.86	disease	0.79	disease	0.63	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	-0.09	medium_impact	2.79	high_impact	0.62	0.8	59.12	10.38	0.49	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3890	3890	G	A	MI.11964	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	584	195	R	Q	cGa/cAa	2.75	0.98	0	probably_damaging	1	neutral	0.49	neutral	1.65	deleterious	-5.17	deleterious	-3.8	high_impact	4.56	0.72	neutral	0.1	damaging	4.56	24.40	deleterious	0.17	0.45	0.58	disease	0.84	disease	0.74	disease	0.7	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.27	medium_impact	2.79	high_impact	0.81	0.85	59.12	10.38	0.73	P	1.00	disease_causing_automatic	0	0.48	rs587776434	Pathogenic	Leigh_syndrome	165630	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	.	.	G3890A	Progressive Encephalomyopathy / LS / Optic Atrophy	-	+	Cfrm	5	P	P	P	damaging
chrM	3890	3890	G	C	MI.11965	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	584	195	R	P	cGa/cCa	2.75	0.98	0	probably_damaging	1	neutral	0.31	neutral	1.61	deleterious	-6.63	deleterious	-6.66	high_impact	4.91	0.63	neutral	0.06	damaging	4.30	24.00	deleterious	0.02	0.35	0.84	disease	0.87	disease	0.75	disease	0.64	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.08	medium_impact	3.1	high_impact	0.10	0.8	59.12	10.38	0.71	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3890	3890	G	T	MI.11966	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	584	195	R	L	cGa/cTa	2.75	0.98	0	probably_damaging	1	neutral	0.99	neutral	1.63	deleterious	-5.7	deleterious	-6.66	high_impact	4.91	0.75	neutral	0.09	damaging	4.31	24.00	deleterious	0.04	0.35	0.75	disease	0.9	disease	0.77	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.57	low_impact	1.39	medium_impact	3.1	high_impact	0.02	0.8	59.12	10.38	0.72	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3892	3892	A	G	MI.11967	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	586	196	T	A	Acc/Gcc	-2.08	0	0	benign	0.01	neutral	0.9	neutral	2.91	neutral	0.7	neutral	2.95	neutral_impact	-0.97	0.65	neutral	0.86	neutral	-1.06	0.01	neutral	0.34	0.5	0.14	neutral	0.05	neutral	0.23	neutral	0.2	neutral	6	0.06	neutral	0.95	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.81	medium_impact	-2.04	low_impact	0.56	0.8	16.98	21.4	0.33	N	0.00	polymorphism	1	0.01	rs879131781	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3892	3892	A	T	MI.11968	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	586	196	T	S	Acc/Tcc	-2.08	0	0	benign	0.32	neutral	0.78	neutral	2.8	neutral	-0.32	neutral	0.54	neutral_impact	0.16	0.78	neutral	0.76	neutral	1.53	13.47	neutral	0.44	0.55	0.22	neutral	0.37	neutral	0.3	neutral	0.42	neutral	2	0.21	neutral	0.73	deleterious	-6	neutral	0.30	neutral	-0.44	medium_impact	0.58	medium_impact	-1.05	low_impact	0.65	0.8	16.98	21.4	0.22	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3892	3892	A	C	MI.11969	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	586	196	T	P	Acc/Ccc	-2.08	0	0	possibly_damaging	0.72	neutral	0.28	neutral	2.75	neutral	-1.15	neutral	-1.39	low_impact	1.56	0.57	damaging	0.47	neutral	1.86	15.32	deleterious	0.06	0.35	0.22	neutral	0.82	disease	0.6	disease	0.73	disease	5	0.8	neutral	0.28	neutral	-3	neutral	0.59	deleterious	-1.14	low_impact	0.05	medium_impact	0.17	medium_impact	0.37	0.8	16.98	21.4	0.35	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9089	9089	C	T	MI.1197	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	563	188	S	F	tCt/tTt	-0.57	0	0	benign	0.07	neutral	0.24	neutral	4.39	neutral	-0.05	neutral	-1.09	neutral_impact	-0.32	0.89	neutral	0.54	neutral	2.37	18.65	deleterious	0.27	0.65	0.43	neutral	0.62	disease	0.47	neutral	0.5	disease	0	0.74	neutral	0.59	deleterious	-6	neutral	0.21	neutral	0.31	medium_impact	0.01	medium_impact	-1.37	low_impact	0.60	0.9	27.88	19.63	0.36	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3893	3893	C	A	MI.11970	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	587	196	T	N	aCc/aAc	2.98	0.99	0	possibly_damaging	0.78	neutral	0.53	neutral	2.78	neutral	-1.37	neutral	-2.13	medium_impact	2.17	0.57	damaging	0.64	neutral	2.12	16.98	deleterious	0.4	0.5	0.27	neutral	0.73	disease	0.64	disease	0.69	disease	4	0.75	neutral	0.38	neutral	0	NA	0.58	deleterious	-1.27	low_impact	0.3	medium_impact	0.71	medium_impact	0.52	0.8	16.98	21.4	0.51	P	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3893	3893	C	G	MI.11971	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	587	196	T	S	aCc/aGc	2.98	0.99	0	benign	0.32	neutral	0.78	neutral	2.8	neutral	-0.32	neutral	0.54	neutral_impact	0.16	0.78	neutral	0.76	neutral	1.67	14.22	neutral	0.44	0.55	0.22	neutral	0.37	neutral	0.3	neutral	0.42	neutral	2	0.21	neutral	0.73	deleterious	-6	neutral	0.30	neutral	-0.44	medium_impact	0.58	medium_impact	-1.05	low_impact	0.65	0.8	16.98	21.4	0.38	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3893	3893	C	T	MI.11972	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	587	196	T	I	aCc/aTc	2.98	0.99	0	possibly_damaging	0.52	neutral	0.22	neutral	2.77	neutral	-0.74	neutral	-1.42	low_impact	1.79	0.61	neutral	0.6	neutral	2.19	17.47	deleterious	0.19	0.45	0.22	neutral	0.63	disease	0.59	disease	0.68	disease	4	0.76	neutral	0.35	neutral	-3	neutral	0.47	deleterious	-0.78	medium_impact	-0.03	medium_impact	0.38	medium_impact	0.57	0.8	16.98	21.4	0.58	P	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3895	3895	C	T	MI.11973	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	589	197	P	S	Ccc/Tcc	-5.52	0	0	probably_damaging	1	neutral	0.82	neutral	1.21	deleterious	-7.13	deleterious	-7.61	high_impact	4.88	0.73	neutral	0.11	damaging	4.03	23.60	deleterious	0.06	0.35	0.89	disease	0.77	disease	0.67	disease	0.64	disease	3	1	deleterious	0.41	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.64	medium_impact	3.07	high_impact	0.08	0.8	59.43	10.41	0.58	P	0.74	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3895	3895	C	G	MI.11974	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	589	197	P	A	Ccc/Gcc	-5.52	0	0	probably_damaging	1	neutral	1	neutral	1.22	deleterious	-6.91	deleterious	-7.61	high_impact	4.88	0.71	neutral	0.12	damaging	3.23	22.80	deleterious	0.08	0.35	0.87	disease	0.56	disease	0.71	disease	0.68	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.83	deleterious	-3.57	low_impact	1.96	high_impact	3.07	high_impact	0.61	0.8	59.43	10.41	0.57	N	0.78	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3895	3895	C	A	MI.11975	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	589	197	P	T	Ccc/Acc	-5.52	0	0	probably_damaging	1	neutral	0.8	neutral	1.19	deleterious	-7.5	deleterious	-7.61	high_impact	4.88	0.68	neutral	0.1	damaging	3.83	23.40	deleterious	0.06	0.35	0.91	disease	0.73	disease	0.7	disease	0.64	disease	3	1	deleterious	0.4	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.61	medium_impact	3.07	high_impact	0.45	0.8	59.43	10.41	0.56	N	0.91	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3896	3896	C	A	MI.11976	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	590	197	P	H	cCc/cAc	5.5	1	0	probably_damaging	1	neutral	0.57	neutral	1.17	deleterious	-7.97	deleterious	-8.56	high_impact	4.88	0.71	neutral	0.09	damaging	4.17	23.80	deleterious	0.04	0.35	0.97	disease	0.76	disease	0.78	disease	0.73	disease	5	1	deleterious	0.29	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.34	medium_impact	3.07	high_impact	0.20	0.8	59.43	10.41	0.69	P	0.69	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3896	3896	C	G	MI.11977	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	590	197	P	R	cCc/cGc	5.5	1	0	probably_damaging	1	neutral	0.69	neutral	1.18	deleterious	-7.99	deleterious	-8.56	high_impact	4.34	0.81	neutral	0.12	damaging	3.73	23.30	deleterious	0.04	0.35	0.94	disease	0.77	disease	0.74	disease	0.66	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.47	medium_impact	2.6	high_impact	0.17	0.8	59.43	10.41	0.59	P	0.71	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3896	3896	C	T	MI.11978	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	590	197	P	L	cCc/cTc	5.5	1	0	probably_damaging	1	neutral	0.84	neutral	1.19	deleterious	-6.87	deleterious	-9.51	high_impact	4.34	0.68	neutral	0.08	damaging	4.55	24.30	deleterious	0.03	0.35	0.94	disease	0.76	disease	0.66	disease	0.65	disease	3	1	deleterious	0.42	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.68	medium_impact	2.6	high_impact	0.52	0.8	59.43	10.41	0.58	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3898	3898	T	A	MI.11979	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	592	198	F	I	Ttc/Atc	-11.27	0	0	probably_damaging	1	neutral	0.44	neutral	1.69	deleterious	-4.92	deleterious	-5.72	high_impact	4.84	0.74	neutral	0.17	damaging	4.52	24.30	deleterious	0.06	0.35	0.63	disease	0.75	disease	0.72	disease	0.67	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.22	medium_impact	3.04	high_impact	0.18	0.8	59.75	10.34	0.65	P	0.97	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9089	9089	C	G	MI.1198	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	563	188	S	C	tCt/tGt	-0.57	0	0	benign	0.43	deleterious	0.04	neutral	4.3	neutral	-2.51	neutral	-0.78	low_impact	1.12	0.76	neutral	0.42	neutral	2.06	16.57	deleterious	0.24	0.65	0.64	disease	0.55	disease	0.38	neutral	0.5	neutral	0	0.95	neutral	0.31	neutral	-2	neutral	0.44	deleterious	-0.64	medium_impact	-0.49	medium_impact	-0.14	medium_impact	0.69	0.9	27.88	19.63	0.38	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3898	3898	T	C	MI.11980	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	592	198	F	L	Ttc/Ctc	-11.27	0	0	probably_damaging	1	neutral	0.73	neutral	1.75	deleterious	-3.84	deleterious	-5.72	high_impact	3.52	0.73	neutral	0.15	damaging	4.17	23.80	deleterious	0.06	0.35	0.53	disease	0.75	disease	0.69	disease	0.66	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.52	medium_impact	1.89	medium_impact	0.23	0.8	59.75	10.34	0.32	N	0.92	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3898	3898	T	G	MI.11981	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	592	198	F	V	Ttc/Gtc	-11.27	0	0	probably_damaging	1	neutral	0.56	neutral	1.69	deleterious	-4.94	deleterious	-6.67	high_impact	4.14	0.64	neutral	0.15	damaging	4.26	23.90	deleterious	0.06	0.35	0.5	neutral	0.81	disease	0.72	disease	0.67	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.33	medium_impact	2.43	high_impact	0.19	0.8	59.75	10.34	0.32	N	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3899	3899	T	A	MI.11982	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	593	198	F	Y	tTc/tAc	7.34	1	0	probably_damaging	1	neutral	1	neutral	1.75	deleterious	-3.94	deleterious	-2.86	high_impact	3.8	0.73	neutral	0.14	damaging	4.37	24.10	deleterious	0.09	0.35	0.55	disease	0.73	disease	0.67	disease	0.65	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.80	deleterious	-3.57	low_impact	1.96	high_impact	2.13	high_impact	0.37	0.8	59.75	10.34	0.56	P	0.88	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3899	3899	T	C	MI.11983	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	593	198	F	S	tTc/tCc	7.34	1	0	probably_damaging	1	neutral	0.58	neutral	1.66	deleterious	-6.03	deleterious	-7.63	high_impact	4.03	0.77	neutral	0.19	damaging	4.36	24.10	deleterious	0.03	0.35	0.66	disease	0.86	disease	0.66	disease	0.69	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.35	medium_impact	2.33	high_impact	0.06	0.8	59.75	10.34	0.57	P	0.98	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3899	3899	T	G	MI.11984	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	593	198	F	C	tTc/tGc	7.34	1	0	probably_damaging	1	neutral	0.19	neutral	1.64	deleterious	-7.58	deleterious	-7.63	high_impact	4.29	0.72	neutral	0.13	damaging	4.24	23.90	deleterious	0.03	0.35	0.89	disease	0.83	disease	0.74	disease	0.62	disease	2	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.08	medium_impact	2.56	high_impact	0.10	0.8	59.75	10.34	0.65	P	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3900	3900	C	G	MI.11985	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	594	198	F	L	ttC/ttG	7.34	1	0	probably_damaging	1	neutral	0.73	neutral	1.75	deleterious	-3.84	deleterious	-5.72	high_impact	3.52	0.73	neutral	0.15	damaging	4.45	24.20	deleterious	0.06	0.35	0.53	disease	0.75	disease	0.69	disease	0.66	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.52	medium_impact	1.89	medium_impact	0.23	0.8	59.75	10.34	0.56	N	0.92	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3900	3900	C	A	MI.11986	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	594	198	F	L	ttC/ttA	7.34	1	0	probably_damaging	1	neutral	0.73	neutral	1.75	deleterious	-3.84	deleterious	-5.72	high_impact	3.52	0.73	neutral	0.15	damaging	4.72	24.60	deleterious	0.06	0.35	0.53	disease	0.75	disease	0.69	disease	0.66	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.52	medium_impact	1.89	medium_impact	0.23	0.8	59.75	10.34	0.57	P	0.92	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3901	3901	G	C	MI.11987	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	595	199	D	H	Gac/Cac	-3.92	0	0	probably_damaging	1	neutral	0.12	neutral	1.55	deleterious	-6.19	deleterious	-6.67	high_impact	4.88	0.62	neutral	0.26	damaging	3.71	23.30	deleterious	0.05	0.35	0.92	disease	0.85	disease	0.73	disease	0.61	disease	2	1	deleterious	0.06	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.21	medium_impact	3.07	high_impact	0.32	0.8	59.75	10.21	0.6	P	0.99	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3901	3901	G	T	MI.11988	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	595	199	D	Y	Gac/Tac	-3.92	0	0	probably_damaging	1	neutral	0.05	neutral	1.54	deleterious	-8.2	deleterious	-8.57	high_impact	4.88	0.67	neutral	0.28	damaging	4.01	23.60	deleterious	0.03	0.35	0.95	disease	0.92	disease	0.74	disease	0.61	disease	2	1	deleterious	0.03	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	-0.44	medium_impact	3.07	high_impact	0.06	0.8	59.75	10.21	0.56	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3901	3901	G	A	MI.11989	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	595	199	D	N	Gac/Aac	-3.92	0	0	probably_damaging	1	neutral	0.53	neutral	1.59	deleterious	-4.74	deleterious	-4.76	high_impact	4.53	0.68	neutral	0.35	neutral	4.30	24.00	deleterious	0.34	0.5	0.81	disease	0.83	disease	0.69	disease	0.65	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.3	medium_impact	2.77	high_impact	0.43	0.8	59.75	10.21	0.51	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9089	9089	C	A	MI.1199	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	563	188	S	Y	tCt/tAt	-0.57	0	0	benign	0.25	neutral	0.25	neutral	4.33	neutral	-1.15	neutral	-1.26	neutral_impact	0.67	0.92	neutral	0.61	neutral	2.32	18.33	deleterious	0.23	0.65	0.5	neutral	0.57	disease	0.46	neutral	0.49	neutral	0	0.7	neutral	0.5	deleterious	-6	neutral	0.32	neutral	-0.3	medium_impact	0.02	medium_impact	-0.52	medium_impact	0.76	0.9	27.88	19.63	0.34	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3902	3902	A	T	MI.11990	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	596	199	D	V	gAc/gTc	7.11	1	0	probably_damaging	1	neutral	0.27	neutral	1.55	deleterious	-7.09	deleterious	-8.57	high_impact	4.33	0.61	neutral	0.33	neutral	4.45	24.20	deleterious	0.03	0.35	0.93	disease	0.89	disease	0.7	disease	0.6	disease	2	1	deleterious	0.14	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.03	medium_impact	2.59	high_impact	0.05	0.8	59.75	10.21	0.66	P	1.00	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3902	3902	A	C	MI.11991	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	596	199	D	A	gAc/gCc	7.11	1	0	probably_damaging	1	neutral	0.73	neutral	1.58	deleterious	-5.75	deleterious	-7.62	high_impact	4.88	0.66	neutral	0.39	neutral	4.26	23.90	deleterious	0.05	0.35	0.85	disease	0.83	disease	0.68	disease	0.63	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.52	medium_impact	3.07	high_impact	0.14	0.8	59.75	10.21	0.71	P	0.94	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3902	3902	A	G	MI.11992	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	596	199	D	G	gAc/gGc	7.11	1	0	probably_damaging	1	neutral	0.34	neutral	1.57	deleterious	-6.25	deleterious	-6.67	high_impact	4.88	0.64	neutral	0.38	neutral	4.64	24.50	deleterious	0.05	0.35	0.84	disease	0.86	disease	0.7	disease	0.64	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.11	medium_impact	3.07	high_impact	0.19	0.8	59.75	10.21	0.75	P	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3903	3903	C	G	MI.11993	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	597	199	D	E	gaC/gaG	6.65	1	0	probably_damaging	1	neutral	1	neutral	1.64	deleterious	-4.08	deleterious	-3.81	high_impact	4.88	0.7	neutral	0.35	neutral	4.02	23.60	deleterious	0.13	0.4	0.72	disease	0.79	disease	0.67	disease	0.65	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.57	low_impact	1.96	high_impact	3.07	high_impact	0.36	0.8	59.75	10.21	0.76	P	0.95	polymorphism	0.97	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3903	3903	C	A	MI.11994	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	597	199	D	E	gaC/gaA	6.65	1	0	probably_damaging	1	neutral	1	neutral	1.64	deleterious	-4.08	deleterious	-3.81	high_impact	4.88	0.7	neutral	0.35	neutral	4.36	24.10	deleterious	0.13	0.4	0.72	disease	0.79	disease	0.67	disease	0.65	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.57	low_impact	1.96	high_impact	3.07	high_impact	0.36	0.8	59.75	10.21	0.76	P	0.95	polymorphism	0.97	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3904	3904	C	A	MI.11995	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	598	200	L	I	Ctt/Att	-1.39	0	0	probably_damaging	1	neutral	0.37	neutral	2.28	neutral	-2.68	neutral	-1.9	medium_impact	3.3	0.61	neutral	0.06	damaging	4.35	24.10	deleterious	0.37	0.5	0.27	neutral	0.5	neutral	0.54	disease	0.57	disease	1	1	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.15	medium_impact	1.69	medium_impact	0.41	0.8	58.81	10.38	0.36	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3904	3904	C	G	MI.11996	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	598	200	L	V	Ctt/Gtt	-1.39	0	0	probably_damaging	1	neutral	0.5	neutral	2.28	neutral	-2.78	deleterious	-2.85	medium_impact	3.15	0.57	damaging	0.05	damaging	3.52	23.10	deleterious	0.31	0.45	0.25	neutral	0.48	neutral	0.58	disease	0.52	disease	0	1	deleterious	0.25	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.28	medium_impact	1.56	medium_impact	0.34	0.8	58.81	10.38	0.28	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3904	3904	C	T	MI.11997	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	598	200	L	F	Ctt/Ttt	-1.39	0	0	probably_damaging	1	neutral	0.46	neutral	2.33	neutral	-2.18	deleterious	-3.78	low_impact	1.88	0.57	damaging	0.04	damaging	4.06	23.70	deleterious	0.34	0.5	0.33	neutral	0.2	neutral	0.24	neutral	0.34	neutral	3	1	deleterious	0.23	neutral	-2	neutral	0.71	deleterious	-3.57	low_impact	0.24	medium_impact	0.45	medium_impact	0.39	0.8	58.81	10.38	0.29	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3905	3905	T	C	MI.11998	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	599	200	L	P	cTt/cCt	-0.01	0	0	probably_damaging	1	neutral	0.37	neutral	2.18	deleterious	-5.65	deleterious	-6.65	high_impact	3.85	0.44	damaging	0.04	damaging	3.99	23.60	deleterious	0.04	0.35	0.67	disease	0.78	disease	0.6	disease	0.64	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.15	medium_impact	2.17	high_impact	0.12	0.8	58.81	10.38	0.38	N	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3905	3905	T	A	MI.11999	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	599	200	L	H	cTt/cAt	-0.01	0	0	probably_damaging	1	neutral	0.38	neutral	2.18	deleterious	-5.38	deleterious	-6.65	high_impact	4.2	0.54	damaging	0.04	damaging	4.17	23.80	deleterious	0.07	0.35	0.66	disease	0.73	disease	0.68	disease	0.64	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.16	medium_impact	2.48	high_impact	0.21	0.8	58.81	10.38	0.31	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8531	8531	A	C	MI.12	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	5	2	N	T	aAc/aCc	6.84	1	0	probably_damaging	0.97	neutral	0.46	neutral	4.67	neutral	-0.37	deleterious	-2.81	low_impact	1.05	0.79	neutral	0.61	neutral	3.61	23.20	deleterious	0.71	0.75	0.41	neutral	0.08	neutral	0.06	neutral	0.28	neutral	4	0.97	neutral	0.25	neutral	-2	neutral	0.63	deleterious	-2.19	low_impact	0.25	medium_impact	-0.2	medium_impact	0.38	0.9	41.59	7.23	0.56	P	0.96	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8582	8582	C	G	MI.120	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	56	19	A	G	gCc/gGc	-0.57	0	0	probably_damaging	0.99	deleterious	0	neutral	4.59	neutral	-2.11	deleterious	-2.92	low_impact	0.8	0.79	neutral	0.59	neutral	3.79	23.40	deleterious	0.19	0.65	0.56	disease	0.47	neutral	0.44	neutral	0.62	disease	2	1	deleterious	0.01	neutral	2	deleterious	0.73	deleterious	-2.65	low_impact	-1.4	low_impact	-0.41	medium_impact	0.68	0.9	29.65	29.28	0.33	N	0.52	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9091	9091	A	G	MI.1200	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	565	189	T	A	Aca/Gca	-5.66	0	0.01	benign	0.01	neutral	1	neutral	4.51	neutral	0.04	neutral	0.63	neutral_impact	-1.18	0.91	neutral	0.96	neutral	-1.07	0.01	neutral	0.64	0.7	0.3	neutral	0.07	neutral	0.27	neutral	0.21	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.12	neutral	1.14	medium_impact	1.98	high_impact	-2.11	low_impact	0.46	0.9	29.2	23.91	0.28	N	0.00	polymorphism	1	0.01	rs1057520079	Uncertain_significance	not_provided	363754	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3905	3905	T	G	MI.12000	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	599	200	L	R	cTt/cGt	-0.01	0	0	probably_damaging	1	neutral	0.66	neutral	2.19	deleterious	-4.78	deleterious	-5.7	high_impact	4.54	0.47	damaging	0.04	damaging	4.28	24.00	deleterious	0.04	0.35	0.57	disease	0.78	disease	0.72	disease	0.67	disease	3	1	deleterious	0.33	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.44	medium_impact	2.78	high_impact	0.17	0.8	58.81	10.38	0.46	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3907	3907	G	A	MI.12001	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	601	201	A	T	Gcc/Acc	-10.81	0	0	benign	0	neutral	0.59	neutral	2.78	neutral	-1.64	neutral	4.22	neutral_impact	-0.7	0.59	damaging	0.78	neutral	-0.33	0.58	neutral	0.31	0.45	0.21	neutral	0.06	neutral	0.13	neutral	0.23	neutral	5	0.41	neutral	0.8	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.36	medium_impact	-1.8	low_impact	0.50	0.8	20.13	14.24	0.44	N	0.05	polymorphism	1	0.01	rs876661354	Uncertain_significance	not_specified	236827	MedGen:CN169374	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3907	3907	G	T	MI.12002	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	601	201	A	S	Gcc/Tcc	-10.81	0	0	benign	0.01	neutral	0.74	neutral	2.73	neutral	-1.16	neutral	0.77	neutral_impact	0.36	0.78	neutral	0.79	neutral	1.85	15.26	deleterious	0.37	0.5	0.26	neutral	0.48	neutral	0.21	neutral	0.29	neutral	4	0.24	neutral	0.87	deleterious	-6	neutral	0.18	neutral	1.12	medium_impact	0.53	medium_impact	-0.87	medium_impact	0.31	0.8	20.13	14.24	0.31	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3907	3907	G	C	MI.12003	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	601	201	A	P	Gcc/Ccc	-10.81	0	0	benign	0.04	neutral	0.28	neutral	2.81	neutral	0.72	neutral	-1.1	neutral_impact	0.3	0.55	damaging	0.44	neutral	1.97	16.02	deleterious	0.14	0.4	0.15	neutral	0.73	disease	0.22	neutral	0.18	neutral	6	0.7	neutral	0.62	deleterious	-6	neutral	0.20	neutral	0.55	medium_impact	0.05	medium_impact	-0.93	medium_impact	0.44	0.8	20.13	14.24	0.43	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3908	3908	C	G	MI.12004	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	602	201	A	G	gCc/gGc	3.21	0.98	0	benign	0.01	neutral	0.39	neutral	2.65	neutral	-2.89	neutral	-1.98	low_impact	1.8	0.49	damaging	0.64	neutral	2.14	17.11	deleterious	0.33	0.5	0.44	neutral	0.51	disease	0.45	neutral	0.5	neutral	0	0.6	neutral	0.69	deleterious	-6	neutral	0.19	neutral	1.12	medium_impact	0.17	medium_impact	0.38	medium_impact	0.59	0.8	20.13	14.24	0.65	P	0.31	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3908	3908	C	T	MI.12005	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	602	201	A	V	gCc/gTc	3.21	0.98	0	benign	0	neutral	0.31	neutral	2.68	neutral	-1.16	neutral	-0.08	low_impact	1.04	0.56	damaging	0.78	neutral	2.66	20.60	deleterious	0.27	0.45	0.37	neutral	0.5	disease	0.48	neutral	0.46	neutral	1	0.69	neutral	0.66	deleterious	-6	neutral	0.18	neutral	2.07	high_impact	0.08	medium_impact	-0.28	medium_impact	0.53	0.8	20.13	14.24	0.62	P	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3908	3908	C	A	MI.12006	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	602	201	A	D	gCc/gAc	3.21	0.98	0	benign	0.02	neutral	0.63	neutral	2.63	neutral	-2.82	neutral	-1.18	medium_impact	2.73	0.61	neutral	0.52	neutral	2.64	20.50	deleterious	0.09	0.35	0.37	neutral	0.77	disease	0.54	disease	0.67	disease	3	0.33	neutral	0.81	deleterious	-3	neutral	0.22	neutral	0.84	medium_impact	0.4	medium_impact	1.2	medium_impact	0.23	0.8	20.13	14.24	0.52	N	0.21	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3910	3910	G	C	MI.12007	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	604	202	E	Q	Gaa/Caa	-4.15	0	0	probably_damaging	1	neutral	0.64	neutral	1.75	deleterious	-5.04	deleterious	-2.85	high_impact	4.8	0.68	neutral	0.13	damaging	3.49	23.10	deleterious	0.33	0.5	0.44	neutral	0.78	disease	0.64	disease	0.66	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.42	medium_impact	3	high_impact	0.51	0.8	60.06	10.22	0.63	P	0.91	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3910	3910	G	A	MI.12008	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	604	202	E	K	Gaa/Aaa	-4.15	0	0	probably_damaging	1	neutral	0.94	neutral	1.77	deleterious	-4.61	deleterious	-3.79	high_impact	4.11	0.74	neutral	0.13	damaging	4.56	24.40	deleterious	0.11	0.4	0.35	neutral	0.87	disease	0.63	disease	0.68	disease	4	1	deleterious	0.47	deleterious	2	deleterious	0.82	deleterious	-3.57	low_impact	0.94	medium_impact	2.4	high_impact	0.68	0.85	60.06	10.22	0.34	N	0.99	polymorphism	1	0.29	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3911	3911	A	T	MI.12009	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	605	202	E	V	gAa/gTa	8.95	1	0	probably_damaging	1	neutral	0.48	neutral	1.73	deleterious	-5.97	deleterious	-6.65	high_impact	4.11	0.63	neutral	0.12	damaging	4.39	24.10	deleterious	0.08	0.35	0.47	neutral	0.87	disease	0.67	disease	0.7	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.26	medium_impact	2.4	high_impact	0.31	0.8	60.06	10.22	0.57	P	0.83	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9091	9091	A	C	MI.1201	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	565	189	T	P	Aca/Cca	-5.66	0	0.01	possibly_damaging	0.44	neutral	0.1	neutral	4.35	neutral	-1.83	neutral	-2.17	low_impact	1.3	0.9	neutral	0.61	neutral	3.13	22.60	deleterious	0.17	0.65	0.39	neutral	0.83	disease	0.67	disease	0.81	disease	6	0.89	neutral	0.33	neutral	-3	neutral	0.52	deleterious	-0.66	medium_impact	-0.25	medium_impact	0.02	medium_impact	0.68	0.9	29.2	23.91	0.4	N	0.24	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3911	3911	A	C	MI.12010	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	605	202	E	A	gAa/gCa	8.95	1	0	probably_damaging	1	neutral	0.89	neutral	1.75	deleterious	-4.91	deleterious	-5.7	high_impact	4.8	0.69	neutral	0.15	damaging	3.81	23.40	deleterious	0.09	0.35	0.36	neutral	0.77	disease	0.62	disease	0.65	disease	3	1	deleterious	0.45	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.78	medium_impact	3	high_impact	0.43	0.8	60.06	10.22	0.66	P	0.74	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3911	3911	A	G	MI.12011	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	605	202	E	G	gAa/gGa	8.95	1	0	probably_damaging	1	neutral	0.48	neutral	1.74	deleterious	-5.26	deleterious	-6.65	high_impact	4.8	0.69	neutral	0.17	damaging	4.39	24.10	deleterious	0.11	0.4	0.58	disease	0.79	disease	0.66	disease	0.66	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.26	medium_impact	3	high_impact	0.30	0.8	60.06	10.22	0.72	P	0.61	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3912	3912	A	T	MI.12012	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	606	202	E	D	gaA/gaT	6.65	1	0	probably_damaging	1	neutral	0.64	neutral	1.8	deleterious	-3.99	deleterious	-2.85	high_impact	4.11	0.77	neutral	0.15	damaging	3.96	23.60	deleterious	0.27	0.45	0.47	neutral	0.75	disease	0.59	disease	0.64	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.42	medium_impact	2.4	high_impact	0.46	0.8	60.06	10.22	0.58	P	0.90	polymorphism	0.98	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3912	3912	A	C	MI.12013	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	606	202	E	D	gaA/gaC	6.65	1	0	probably_damaging	1	neutral	0.64	neutral	1.8	deleterious	-3.99	deleterious	-2.85	high_impact	4.11	0.77	neutral	0.15	damaging	3.84	23.40	deleterious	0.27	0.45	0.47	neutral	0.75	disease	0.59	disease	0.64	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.42	medium_impact	2.4	high_impact	0.46	0.8	60.06	10.22	0.58	P	0.90	polymorphism	0.98	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3913	3913	G	T	MI.12014	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	607	203	G	W	Ggg/Tgg	-0.24	0.49	0	probably_damaging	1	neutral	0.11	neutral	2.42	deleterious	-6.8	deleterious	-7.61	high_impact	4.54	0.66	neutral	0.1	damaging	4.53	24.30	deleterious	0.04	0.35	0.91	disease	0.88	disease	0.71	disease	0.61	disease	2	1	deleterious	0.06	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.23	medium_impact	2.78	high_impact	0.08	0.8	58.49	10.36	0.48	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3913	3913	G	C	MI.12015	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	607	203	G	R	Ggg/Cgg	-0.24	0.49	0	probably_damaging	1	neutral	0.62	neutral	2.44	deleterious	-3.77	deleterious	-7.61	high_impact	4.19	0.69	neutral	0.09	damaging	4.08	23.70	deleterious	0.05	0.35	0.66	disease	0.87	disease	0.75	disease	0.7	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.39	medium_impact	2.47	high_impact	0.43	0.8	58.49	10.36	0.38	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3914	3914	G	A	MI.12016	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	608	203	G	E	gGg/gAg	8.95	1	0	probably_damaging	1	neutral	1	neutral	2.46	deleterious	-3.18	deleterious	-7.61	high_impact	3.99	0.68	neutral	0.11	damaging	4.07	23.70	deleterious	0.05	0.35	0.63	disease	0.87	disease	0.72	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.57	low_impact	1.96	high_impact	2.3	high_impact	0.21	0.8	58.49	10.36	0.53	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3914	3914	G	C	MI.12017	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	608	203	G	A	gGg/gCg	8.95	1	0	probably_damaging	1	neutral	0.9	neutral	2.92	neutral	0.41	deleterious	-5.7	medium_impact	2	0.63	neutral	0.14	damaging	3.23	22.80	deleterious	0.14	0.4	0.16	neutral	0.7	disease	0.37	neutral	0.16	neutral	7	1	deleterious	0.45	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.81	medium_impact	0.56	medium_impact	0.34	0.8	58.49	10.36	0.44	N	0.76	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3914	3914	G	T	MI.12018	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	608	203	G	V	gGg/gTg	8.95	1	0	probably_damaging	1	neutral	0.5	neutral	2.46	deleterious	-3.11	deleterious	-8.56	high_impact	4.19	0.54	damaging	0.1	damaging	3.88	23.50	deleterious	0.04	0.35	0.52	disease	0.87	disease	0.66	disease	0.69	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.28	medium_impact	2.47	high_impact	0.10	0.8	58.49	10.36	0.59	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3916	3916	G	A	MI.12019	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	610	204	E	K	Gag/Aag	-5.52	0	0	probably_damaging	1	neutral	0.87	neutral	1.77	deleterious	-4.61	deleterious	-3.81	high_impact	4.46	0.52	damaging	0.05	damaging	4.59	24.40	deleterious	0.06	0.35	0.49	neutral	0.9	disease	0.66	disease	0.69	disease	4	1	deleterious	0.44	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.74	medium_impact	2.71	high_impact	0.50	0.8	59.75	10.56	0.43	N	0.99	polymorphism	1	0.25	rs878952713	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9091	9091	A	T	MI.1202	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	565	189	T	S	Aca/Tca	-5.66	0	0.01	benign	0.12	neutral	0.92	neutral	4.49	neutral	-0.28	neutral	0.07	neutral_impact	-0.78	0.88	neutral	0.96	neutral	0.16	4.21	deleterious	0.54	0.65	0.44	neutral	0.14	neutral	0.29	neutral	0.28	neutral	4	0.04	neutral	0.9	deleterious	-6	neutral	0.19	neutral	0.07	medium_impact	0.89	medium_impact	-1.77	low_impact	0.72	0.9	29.2	23.91	0.29	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3916	3916	G	C	MI.12020	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	610	204	E	Q	Gag/Cag	-5.52	0	0	probably_damaging	1	neutral	0.58	neutral	1.75	deleterious	-5.04	deleterious	-2.86	high_impact	4.25	0.51	damaging	0.05	damaging	3.53	23.10	deleterious	0.12	0.4	0.54	disease	0.8	disease	0.69	disease	0.66	disease	3	1	deleterious	0.29	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.35	medium_impact	2.52	high_impact	0.56	0.8	59.75	10.56	0.34	N	0.91	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3917	3917	A	T	MI.12021	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	611	204	E	V	gAg/gTg	7.11	1	0	probably_damaging	1	neutral	0.36	neutral	1.73	deleterious	-5.97	deleterious	-6.67	high_impact	4.8	0.57	damaging	0.06	damaging	4.50	24.30	deleterious	0.04	0.35	0.74	disease	0.9	disease	0.72	disease	0.68	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.14	medium_impact	3	high_impact	0.23	0.8	59.75	10.56	0.72	P	0.83	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3917	3917	A	C	MI.12022	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	611	204	E	A	gAg/gCg	7.11	1	0	probably_damaging	1	neutral	0.78	neutral	1.75	deleterious	-4.91	deleterious	-5.72	high_impact	4.8	0.52	damaging	0.09	damaging	3.95	23.60	deleterious	0.05	0.35	0.55	disease	0.81	disease	0.7	disease	0.67	disease	3	1	deleterious	0.39	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.58	medium_impact	3	high_impact	0.26	0.8	59.75	10.56	0.69	P	0.74	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3917	3917	A	G	MI.12023	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	611	204	E	G	gAg/gGg	7.11	1	0	probably_damaging	1	neutral	0.42	neutral	1.74	deleterious	-5.26	deleterious	-6.67	high_impact	4.46	0.48	damaging	0.08	damaging	4.49	24.30	deleterious	0.06	0.35	0.63	disease	0.82	disease	0.71	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.2	medium_impact	2.71	high_impact	0.12	0.8	59.75	10.56	0.59	P	0.61	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3918	3918	G	T	MI.12024	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	612	204	E	D	gaG/gaT	8.49	1	0	probably_damaging	1	neutral	0.63	neutral	1.8	deleterious	-3.99	deleterious	-2.86	high_impact	4	0.56	damaging	0.05	damaging	3.95	23.60	deleterious	0.11	0.4	0.38	neutral	0.79	disease	0.64	disease	0.65	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.4	medium_impact	2.31	high_impact	0.54	0.8	59.75	10.56	0.56	P	0.90	polymorphism	0.98	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3918	3918	G	C	MI.12025	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	612	204	E	D	gaG/gaC	8.49	1	0	probably_damaging	1	neutral	0.63	neutral	1.8	deleterious	-3.99	deleterious	-2.86	high_impact	4	0.56	damaging	0.05	damaging	3.81	23.40	deleterious	0.11	0.4	0.38	neutral	0.79	disease	0.64	disease	0.65	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.4	medium_impact	2.31	high_impact	0.54	0.8	59.75	10.56	0.55	P	0.90	polymorphism	0.98	0.24	rs28357972	Uncertain_significance	not_specified	236828	MedGen:CN169374	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3919	3919	T	C	MI.12026	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	613	205	S	P	Tcc/Ccc	-0.01	0.8	0	probably_damaging	1	neutral	0.36	neutral	2.58	deleterious	-3.31	deleterious	-4.76	high_impact	4.14	0.75	neutral	0.04	damaging	4.16	23.80	deleterious	0.08	0.35	0.55	disease	0.8	disease	0.78	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.14	medium_impact	2.43	high_impact	0.12	0.8	60.06	10.41	0.45	N	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	T3919C	LHON	+	-	Reported	1	.	P	P	damaging
chrM	3919	3919	T	A	MI.12027	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	613	205	S	T	Tcc/Acc	-0.01	0.8	0	probably_damaging	1	neutral	0.72	neutral	2.63	neutral	-1.25	deleterious	-2.86	medium_impact	3.31	0.63	neutral	0.05	damaging	4.13	23.80	deleterious	0.32	0.5	0.34	neutral	0.68	disease	0.63	disease	0.64	disease	3	1	deleterious	0.36	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.51	medium_impact	1.7	medium_impact	0.48	0.8	60.06	10.41	0.3	N	0.68	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3919	3919	T	G	MI.12028	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	613	205	S	A	Tcc/Gcc	-0.01	0.8	0	probably_damaging	1	neutral	0.94	neutral	2.67	neutral	-1.57	deleterious	-2.86	medium_impact	2.77	0.65	neutral	0.11	damaging	3.83	23.40	deleterious	0.29	0.45	0.21	neutral	0.54	disease	0.6	disease	0.33	neutral	3	1	deleterious	0.47	deleterious	1	deleterious	0.67	deleterious	-3.57	low_impact	0.94	medium_impact	1.23	medium_impact	0.30	0.8	60.06	10.41	0.27	N	0.46	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3920	3920	C	T	MI.12029	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	614	205	S	F	tCc/tTc	7.34	1	0	probably_damaging	1	neutral	0.56	neutral	2.57	deleterious	-4.88	deleterious	-5.71	high_impact	4.69	0.68	neutral	0.02	damaging	4.41	24.10	deleterious	0.07	0.35	0.64	disease	0.84	disease	0.67	disease	0.68	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.33	medium_impact	2.91	high_impact	0.04	0.8	60.06	10.41	0.64	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9092	9092	C	A	MI.1203	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	566	189	T	K	aCa/aAa	0.82	0.36	0	benign	0.19	neutral	0.13	neutral	4.41	neutral	-1.73	neutral	-2	low_impact	1.86	0.86	neutral	0.51	neutral	2.68	20.70	deleterious	0.2	0.65	0.5	disease	0.74	disease	0.68	disease	0.75	disease	5	0.85	neutral	0.47	deleterious	-6	neutral	0.36	neutral	-0.16	medium_impact	-0.18	medium_impact	0.5	medium_impact	0.74	0.9	29.2	23.91	0.28	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3920	3920	C	A	MI.12030	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	614	205	S	Y	tCc/tAc	7.34	1	0	probably_damaging	1	neutral	0.73	neutral	2.57	deleterious	-4.47	deleterious	-5.71	high_impact	4.69	0.7	neutral	0.04	damaging	4.14	23.80	deleterious	0.07	0.35	0.6	disease	0.83	disease	0.7	disease	0.69	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.52	medium_impact	2.91	high_impact	0.16	0.8	60.06	10.41	0.64	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3920	3920	C	G	MI.12031	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	614	205	S	C	tCc/tGc	7.34	1	0	probably_damaging	1	neutral	0.16	neutral	2.56	deleterious	-5.85	deleterious	-4.76	high_impact	4.69	0.71	neutral	0.03	damaging	3.67	23.30	deleterious	0.07	0.35	0.77	disease	0.76	disease	0.66	disease	0.66	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	-0.13	medium_impact	2.91	high_impact	0.24	0.8	60.06	10.41	0.69	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3922	3922	G	A	MI.12032	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	616	206	E	K	Gaa/Aaa	-10.12	0	0	probably_damaging	1	neutral	0.71	neutral	2.19	deleterious	-6.47	deleterious	-3.79	high_impact	4.11	0.54	damaging	0.06	damaging	4.59	24.40	deleterious	0.04	0.35	0.71	disease	0.89	disease	0.76	disease	0.71	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.49	medium_impact	2.4	high_impact	0.75	0.85	59.75	10.58	0.41	N	0.99	polymorphism	1	0.47	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3922	3922	G	C	MI.12033	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	616	206	E	Q	Gaa/Caa	-10.12	0	0	probably_damaging	1	neutral	0.47	neutral	2.17	deleterious	-6.55	deleterious	-2.85	high_impact	4.8	0.53	damaging	0.07	damaging	3.50	23.10	deleterious	0.09	0.4	0.72	disease	0.79	disease	0.72	disease	0.68	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.25	medium_impact	3	high_impact	0.48	0.8	59.75	10.58	0.6	P	0.91	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3923	3923	A	G	MI.12034	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	617	206	E	G	gAa/gGa	5.96	1	0	probably_damaging	1	neutral	0.39	neutral	2.15	deleterious	-6.54	deleterious	-6.64	high_impact	4.46	0.5	damaging	0.1	damaging	4.46	24.20	deleterious	0.03	0.35	0.74	disease	0.81	disease	0.71	disease	0.68	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.17	medium_impact	2.71	high_impact	0.12	0.8	59.75	10.58	0.61	P	0.61	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3923	3923	A	T	MI.12035	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	617	206	E	V	gAa/gTa	5.96	1	0	probably_damaging	1	neutral	0.3	neutral	2.13	deleterious	-8.26	deleterious	-6.64	high_impact	4.46	0.59	damaging	0.07	damaging	4.41	24.20	deleterious	0.02	0.35	0.88	disease	0.9	disease	0.72	disease	0.62	disease	2	1	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.07	medium_impact	2.71	high_impact	0.23	0.8	59.75	10.58	0.63	P	0.83	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3923	3923	A	C	MI.12036	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	617	206	E	A	gAa/gCa	5.96	1	0	probably_damaging	1	neutral	0.65	neutral	2.17	deleterious	-6.66	deleterious	-5.68	high_impact	4.8	0.53	damaging	0.11	damaging	3.78	23.40	deleterious	0.03	0.35	0.73	disease	0.8	disease	0.71	disease	0.68	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.43	medium_impact	3	high_impact	0.27	0.8	59.75	10.58	0.69	P	0.74	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3924	3924	A	T	MI.12037	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	618	206	E	D	gaA/gaT	6.65	1	0	probably_damaging	1	neutral	0.56	neutral	2.24	deleterious	-4.38	deleterious	-2.85	high_impact	3.7	0.58	damaging	0.07	damaging	3.89	23.50	deleterious	0.07	0.35	0.47	neutral	0.79	disease	0.68	disease	0.66	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.33	medium_impact	2.04	high_impact	0.43	0.8	59.75	10.58	0.59	P	0.90	polymorphism	0.98	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3924	3924	A	C	MI.12038	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	618	206	E	D	gaA/gaC	6.65	1	0	probably_damaging	1	neutral	0.56	neutral	2.24	deleterious	-4.38	deleterious	-2.85	high_impact	3.7	0.58	damaging	0.07	damaging	3.78	23.40	deleterious	0.07	0.35	0.47	neutral	0.79	disease	0.68	disease	0.66	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.33	medium_impact	2.04	high_impact	0.43	0.8	59.75	10.58	0.59	P	0.90	polymorphism	0.98	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3925	3925	C	G	MI.12039	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	619	207	L	V	Cta/Gta	0.91	0.43	0	probably_damaging	1	neutral	0.28	neutral	2.33	deleterious	-3.42	deleterious	-2.85	high_impact	3.87	0.59	damaging	0.05	damaging	3.52	23.10	deleterious	0.12	0.4	0.49	neutral	0.66	disease	0.51	disease	0.53	disease	1	1	deleterious	0.14	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.05	medium_impact	2.19	high_impact	0.40	0.8	59.75	10.53	0.34	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9092	9092	C	T	MI.1204	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	566	189	T	M	aCa/aTa	0.82	0.36	0	possibly_damaging	0.78	neutral	0.22	neutral	4.35	neutral	-1.98	neutral	-1.66	neutral_impact	0.7	0.9	neutral	0.63	neutral	3.89	23.50	deleterious	0.35	0.65	0.5	neutral	0.45	neutral	0.36	neutral	0.31	neutral	4	0.86	neutral	0.22	neutral	-3	neutral	0.55	deleterious	-1.28	low_impact	-0.02	medium_impact	-0.5	medium_impact	0.88	0.9	29.2	23.91	0.38	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3925	3925	C	A	MI.12040	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	619	207	L	M	Cta/Ata	0.91	0.43	0	probably_damaging	1	neutral	0.1	neutral	2.24	deleterious	-4.69	neutral	-1.9	high_impact	4.76	0.59	damaging	0.06	damaging	4.03	23.60	deleterious	0.11	0.4	0.64	disease	0.6	disease	0.62	disease	0.64	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.26	medium_impact	2.97	high_impact	0.55	0.8	59.75	10.53	0.65	P	0.89	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3926	3926	T	A	MI.12041	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	620	207	L	Q	cTa/cAa	-0.47	0.2	0	probably_damaging	1	neutral	0.55	neutral	2.22	deleterious	-7.88	deleterious	-5.71	high_impact	4.76	0.48	damaging	0.05	damaging	4.53	24.30	deleterious	0.01	0.35	0.87	disease	0.82	disease	0.64	disease	0.63	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.32	medium_impact	2.97	high_impact	0.24	0.8	59.75	10.53	0.59	P	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3926	3926	T	G	MI.12042	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	620	207	L	R	cTa/cGa	-0.47	0.2	0	probably_damaging	1	neutral	0.49	neutral	2.22	deleterious	-7.96	deleterious	-5.71	high_impact	4.76	0.5	damaging	0.04	damaging	4.36	24.10	deleterious	0.01	0.35	0.87	disease	0.87	disease	0.75	disease	0.65	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.27	medium_impact	2.97	high_impact	0.12	0.8	59.75	10.53	0.64	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3926	3926	T	C	MI.12043	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	620	207	L	P	cTa/cCa	-0.47	0.2	0	probably_damaging	1	neutral	0.26	neutral	2.21	deleterious	-8.26	deleterious	-6.66	high_impact	4.76	0.46	damaging	0.04	damaging	4.11	23.70	deleterious	0.01	0.35	0.9	disease	0.82	disease	0.75	disease	0.64	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.02	medium_impact	2.97	high_impact	0.11	0.8	59.75	10.53	0.6	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3928	3928	G	A	MI.12044	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	622	208	V	I	Gtc/Atc	-1.39	0	0	benign	0.22	neutral	0.41	neutral	2.32	neutral	-2.02	neutral	-0.95	medium_impact	3.17	0.65	neutral	0.1	damaging	3.72	23.30	deleterious	0.43	0.55	0.34	neutral	0.67	disease	0.56	disease	0.63	disease	3	0.5	neutral	0.6	deleterious	-3	neutral	0.26	neutral	-0.24	medium_impact	0.19	medium_impact	1.58	medium_impact	0.77	0.85	59.43	10.43	0.32	N	0.39	polymorphism	1	0.06	.	.	.	.	.	.	COSM1138364	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3928	3928	G	T	MI.12045	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	622	208	V	F	Gtc/Ttc	-1.39	0	0	probably_damaging	0.97	neutral	0.72	neutral	2.18	deleterious	-3.88	deleterious	-4.76	high_impact	4.41	0.56	damaging	0.04	damaging	3.97	23.60	deleterious	0.04	0.35	0.54	disease	0.92	disease	0.69	disease	0.69	disease	4	0.96	neutral	0.38	neutral	2	deleterious	0.83	deleterious	-2.17	low_impact	0.51	medium_impact	2.66	high_impact	0.39	0.8	59.43	10.43	0.37	N	0.99	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3928	3928	G	C	MI.12046	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	622	208	V	L	Gtc/Ctc	-1.39	0	0	possibly_damaging	0.68	neutral	0.74	neutral	2.27	neutral	-2.48	deleterious	-2.85	high_impact	4.75	0.6	damaging	0.04	damaging	3.67	23.30	deleterious	0.15	0.45	0.34	neutral	0.8	disease	0.63	disease	0.65	disease	3	0.62	neutral	0.53	deleterious	1	deleterious	0.57	deleterious	-1.06	low_impact	0.53	medium_impact	2.96	high_impact	0.43	0.8	59.43	10.43	0.57	P	0.71	disease_causing_automatic	0	0.28	rs587776442	Pathogenic	Leigh_syndrome	165640	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	3929	3929	T	G	MI.12047	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	623	208	V	G	gTc/gGc	7.11	1	0	probably_damaging	0.98	neutral	0.45	neutral	2.15	deleterious	-5.09	deleterious	-6.67	high_impact	3.86	0.58	damaging	0.07	damaging	3.93	23.50	deleterious	0.02	0.35	0.58	disease	0.85	disease	0.68	disease	0.68	disease	4	0.98	deleterious	0.24	neutral	2	deleterious	0.81	deleterious	-2.34	low_impact	0.23	medium_impact	2.18	high_impact	0.18	0.8	59.43	10.43	0.55	P	0.95	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3929	3929	T	C	MI.12048	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	623	208	V	A	gTc/gCc	7.11	1	0	possibly_damaging	0.86	neutral	0.61	neutral	2.24	neutral	-2.84	deleterious	-3.81	high_impact	3.66	0.53	damaging	0.09	damaging	3.72	23.30	deleterious	0.14	0.4	0.32	neutral	0.71	disease	0.58	disease	0.63	disease	3	0.83	neutral	0.38	neutral	1	deleterious	0.71	deleterious	-1.49	low_impact	0.38	medium_impact	2.01	high_impact	0.21	0.8	59.43	10.43	0.58	P	0.64	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3929	3929	T	A	MI.12049	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	623	208	V	D	gTc/gAc	7.11	1	0	probably_damaging	0.99	neutral	0.29	neutral	2.14	deleterious	-5.72	deleterious	-6.67	high_impact	4.75	0.63	neutral	0.05	damaging	4.80	24.80	deleterious	0.02	0.35	0.57	disease	0.91	disease	0.77	disease	0.7	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-2.62	low_impact	0.06	medium_impact	2.96	high_impact	0.14	0.8	59.43	10.43	0.73	P	0.99	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9094	9094	C	T	MI.1205	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	568	190	L	F	Ctt/Ttt	-16.07	0	0	possibly_damaging	0.81	neutral	0.52	neutral	4.17	neutral	-1.99	neutral	-1.62	low_impact	0.94	0.95	neutral	0.92	neutral	2.54	19.72	deleterious	0.41	0.65	0.23	neutral	0.27	neutral	0.34	neutral	0.42	neutral	2	0.79	neutral	0.36	neutral	-3	neutral	0.61	deleterious	-1.35	low_impact	0.31	medium_impact	-0.29	medium_impact	0.78	0.9	18.58	14.09	0.37	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3931	3931	T	A	MI.12050	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	625	209	S	T	Tca/Aca	-8.97	0	0	probably_damaging	1	neutral	0.44	neutral	2.69	neutral	-1.34	deleterious	-2.86	high_impact	3.81	0.62	neutral	0.06	damaging	3.85	23.40	deleterious	0.21	0.45	0.25	neutral	0.73	disease	0.6	disease	0.64	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	0.22	medium_impact	2.14	high_impact	0.42	0.8	59.12	10.49	0.33	N	0.68	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3931	3931	T	G	MI.12051	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	625	209	S	A	Tca/Gca	-8.97	0	0	probably_damaging	1	neutral	0.55	neutral	2.84	neutral	0.97	deleterious	-2.86	medium_impact	2.19	0.6	neutral	0.1	damaging	3.78	23.40	deleterious	0.28	0.45	0.16	neutral	0.59	disease	0.45	neutral	0.15	neutral	7	1	deleterious	0.28	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.32	medium_impact	0.72	medium_impact	0.31	0.8	59.12	10.49	0.23	N	0.46	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3931	3931	T	C	MI.12052	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	625	209	S	P	Tca/Cca	-8.97	0	0	probably_damaging	1	neutral	0.22	neutral	2.64	deleterious	-3.01	deleterious	-4.76	high_impact	4.27	0.7	neutral	0.03	damaging	4.09	23.70	deleterious	0.07	0.35	0.52	disease	0.84	disease	0.6	disease	0.67	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.03	medium_impact	2.54	high_impact	0.13	0.8	59.12	10.49	0.36	N	0.99	polymorphism	1	0.34	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3932	3932	C	G	MI.12053	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	626	209	S	W	tCa/tGa	7.34	1	0	probably_damaging	1	neutral	0.18	neutral	2.61	deleterious	-3.79	deleterious	-6.66	high_impact	4.62	0.7	neutral	0.03	damaging	4.49	24.30	deleterious	0.05	0.35	0.82	disease	0.89	disease	0.66	disease	0.66	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	-0.09	medium_impact	2.85	high_impact	0.15	0.8	59.12	10.49	0.65	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3932	3932	C	T	MI.12054	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	626	209	S	L	tCa/tTa	7.34	1	0	probably_damaging	1	neutral	0.71	neutral	2.66	neutral	-2.12	deleterious	-5.71	high_impact	4.27	0.61	neutral	0.02	damaging	4.79	24.70	deleterious	0.07	0.35	0.38	neutral	0.87	disease	0.58	disease	0.67	disease	3	1	deleterious	0.36	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.49	medium_impact	2.54	high_impact	0.48	0.8	59.12	10.49	0.54	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3934	3934	G	T	MI.12055	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	628	210	G	C	Ggc/Tgc	-8.97	0	0	probably_damaging	1	neutral	0.18	neutral	1.08	deleterious	-8.86	deleterious	-8.53	high_impact	4.82	0.44	damaging	0.03	damaging	4.28	24.00	deleterious	0.02	0.35	0.87	disease	0.89	disease	0.77	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.09	medium_impact	3.02	high_impact	0.18	0.8	59.43	10.34	0.5	P	0.98	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3934	3934	G	C	MI.12056	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	628	210	G	R	Ggc/Cgc	-8.97	0	0	probably_damaging	1	neutral	0.4	neutral	1.09	deleterious	-7.75	deleterious	-7.57	high_impact	4.82	0.48	damaging	0.04	damaging	4.12	23.80	deleterious	0.02	0.35	0.87	disease	0.87	disease	0.85	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.92	deleterious	-3.57	low_impact	0.18	medium_impact	3.02	high_impact	0.43	0.8	59.43	10.34	0.58	P	0.99	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3934	3934	G	A	MI.12057	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	628	210	G	S	Ggc/Agc	-8.97	0	0	probably_damaging	1	neutral	0.55	neutral	1.12	deleterious	-5.9	deleterious	-5.68	high_impact	4.47	0.25	damaging	0.06	damaging	4.31	24.00	deleterious	0.02	0.35	0.59	disease	0.86	disease	0.75	disease	0.73	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.32	medium_impact	2.72	high_impact	0.33	0.8	59.43	10.34	0.67	P	0.99	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3935	3935	G	C	MI.12058	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	629	210	G	A	gGc/gCc	7.11	1	0	probably_damaging	1	neutral	0.6	neutral	1.13	deleterious	-5.66	deleterious	-5.68	high_impact	4.82	0.31	damaging	0.07	damaging	3.23	22.80	deleterious	0.02	0.35	0.36	neutral	0.75	disease	0.76	disease	0.7	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.37	medium_impact	3.02	high_impact	0.29	0.8	59.43	10.34	0.77	P	0.76	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3935	3935	G	A	MI.12059	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	629	210	G	D	gGc/gAc	7.11	1	0	probably_damaging	1	neutral	0.29	neutral	1.1	deleterious	-6.71	deleterious	-6.63	high_impact	4.82	0.43	damaging	0.04	damaging	3.99	23.60	deleterious	0.02	0.35	0.83	disease	0.89	disease	0.84	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.06	medium_impact	3.02	high_impact	0.15	0.8	59.43	10.34	0.79	P	1.00	polymorphism	1	0.47	.	.	.	.	.	.	COSM1155624	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9094	9094	C	G	MI.1206	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	568	190	L	V	Ctt/Gtt	-16.07	0	0	benign	0.32	neutral	0.43	neutral	4.23	neutral	-1.24	neutral	-0.52	low_impact	1.57	0.87	neutral	0.8	neutral	0.69	8.74	deleterious	0.44	0.65	0.47	neutral	0.22	neutral	0.34	neutral	0.36	neutral	3	0.49	neutral	0.56	deleterious	-6	neutral	0.34	neutral	-0.45	medium_impact	0.22	medium_impact	0.25	medium_impact	0.75	0.9	18.58	14.09	0.38	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3935	3935	G	T	MI.12060	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	629	210	G	V	gGc/gTc	7.11	1	0	probably_damaging	1	neutral	0.56	neutral	1.09	deleterious	-7.4	deleterious	-8.52	high_impact	4.82	0.39	damaging	0.05	damaging	3.89	23.50	deleterious	0.02	0.35	0.79	disease	0.89	disease	0.79	disease	0.72	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.33	medium_impact	3.02	high_impact	0.15	0.8	59.43	10.34	0.74	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3937	3937	T	G	MI.12061	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	631	211	F	V	Ttc/Gtc	-8.51	0	0	probably_damaging	1	neutral	0.65	neutral	2.44	neutral	-2.86	deleterious	-6.57	high_impact	3.6	0.62	neutral	0.16	damaging	4.27	23.90	deleterious	0.05	0.35	0.24	neutral	0.87	disease	0.67	disease	0.71	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.43	medium_impact	1.96	medium_impact	0.33	0.8	58.81	10.12	0.35	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3937	3937	T	A	MI.12062	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	631	211	F	I	Ttc/Atc	-8.51	0	0	probably_damaging	1	neutral	0.48	neutral	2.43	deleterious	-3.04	deleterious	-5.63	high_impact	4.22	0.72	neutral	0.18	damaging	4.57	24.40	deleterious	0.13	0.4	0.27	neutral	0.83	disease	0.66	disease	0.69	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.26	medium_impact	2.5	high_impact	0.46	0.8	58.81	10.12	0.43	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3937	3937	T	C	MI.12063	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	631	211	F	L	Ttc/Ctc	-8.51	0	0	probably_damaging	1	neutral	0.81	neutral	2.48	neutral	-2.23	deleterious	-5.63	high_impact	3.6	0.74	neutral	0.15	damaging	4.24	23.90	deleterious	0.19	0.45	0.2	neutral	0.79	disease	0.65	disease	0.66	disease	3	1	deleterious	0.41	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.63	medium_impact	1.96	medium_impact	0.70	0.85	58.81	10.12	0.37	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3938	3938	T	A	MI.12064	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	632	211	F	Y	tTc/tAc	7.34	1	0	probably_damaging	1	neutral	1	neutral	2.85	neutral	0.16	deleterious	-2.79	low_impact	1.72	0.77	neutral	0.18	damaging	4.36	24.10	deleterious	0.18	0.45	0.18	neutral	0.71	disease	0.35	neutral	0.2	neutral	6	1	deleterious	0.5	deleterious	-2	neutral	0.74	deleterious	-3.57	low_impact	1.96	high_impact	0.31	medium_impact	0.63	0.8	58.81	10.12	0.47	N	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3938	3938	T	G	MI.12065	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	632	211	F	C	tTc/tGc	7.34	1	0	probably_damaging	1	neutral	0.2	neutral	2.38	deleterious	-5.34	deleterious	-7.52	high_impact	4.57	0.7	neutral	0.15	damaging	4.25	23.90	deleterious	0.03	0.35	0.6	disease	0.87	disease	0.68	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.06	medium_impact	2.8	high_impact	0.13	0.8	58.81	10.12	0.63	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3938	3938	T	C	MI.12066	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	632	211	F	S	tTc/tCc	7.34	1	0	probably_damaging	1	neutral	0.8	neutral	2.41	deleterious	-3.68	deleterious	-7.5	high_impact	4.57	0.69	neutral	0.19	damaging	4.39	24.10	deleterious	0.02	0.35	0.39	neutral	0.88	disease	0.65	disease	0.71	disease	4	1	deleterious	0.4	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.61	medium_impact	2.8	high_impact	0.22	0.8	58.81	10.12	0.56	P	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3939	3939	C	G	MI.12067	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	633	211	F	L	ttC/ttG	4.58	1	0	probably_damaging	1	neutral	0.81	neutral	2.48	neutral	-2.23	deleterious	-5.63	high_impact	3.6	0.74	neutral	0.15	damaging	4.49	24.30	deleterious	0.19	0.45	0.2	neutral	0.79	disease	0.65	disease	0.66	disease	3	1	deleterious	0.41	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.63	medium_impact	1.96	medium_impact	0.70	0.85	58.81	10.12	0.48	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3939	3939	C	A	MI.12068	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	633	211	F	L	ttC/ttA	4.58	1	0	probably_damaging	1	neutral	0.81	neutral	2.48	neutral	-2.23	deleterious	-5.63	high_impact	3.6	0.74	neutral	0.15	damaging	4.81	24.80	deleterious	0.19	0.45	0.2	neutral	0.79	disease	0.65	disease	0.66	disease	3	1	deleterious	0.41	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.63	medium_impact	1.96	medium_impact	0.70	0.85	58.81	10.12	0.5	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3940	3940	A	C	MI.12069	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	634	212	N	H	Aac/Cac	-3.92	0	0	probably_damaging	1	neutral	0.54	neutral	2.63	neutral	0.99	deleterious	-4.75	medium_impact	2.46	0.65	neutral	0.08	damaging	3.20	22.70	deleterious	0.29	0.45	0.32	neutral	0.79	disease	0.7	disease	0.7	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.78	deleterious	-3.57	low_impact	0.31	medium_impact	0.96	medium_impact	0.18	0.8	60.38	10.35	0.23	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9094	9094	C	A	MI.1207	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	568	190	L	I	Ctt/Att	-16.07	0	0	benign	0.43	neutral	0.98	neutral	4.4	neutral	0.04	neutral	-0.44	neutral_impact	0.2	0.87	neutral	0.9	neutral	0.54	7.77	deleterious	0.44	0.65	0.34	neutral	0.08	neutral	0.25	neutral	0.28	neutral	4	0.4	neutral	0.78	deleterious	-6	neutral	0.43	neutral	-0.64	medium_impact	1.25	medium_impact	-0.93	medium_impact	0.73	0.9	18.58	14.09	0.38	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3940	3940	A	T	MI.12070	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	634	212	N	Y	Aac/Tac	-3.92	0	0	probably_damaging	1	neutral	1	neutral	2.6	neutral	-0.81	deleterious	-7.61	high_impact	3.93	0.66	neutral	0.07	damaging	3.83	23.40	deleterious	0.07	0.35	0.41	neutral	0.89	disease	0.69	disease	0.71	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.82	deleterious	-3.57	low_impact	1.96	high_impact	2.24	high_impact	0.12	0.8	60.38	10.35	0.29	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3940	3940	A	G	MI.12071	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	634	212	N	D	Aac/Gac	-3.92	0	0	probably_damaging	1	neutral	0.21	neutral	2.65	neutral	-1.66	deleterious	-4.75	high_impact	4.62	0.78	neutral	0.13	damaging	3.93	23.50	deleterious	0.34	0.5	0.4	neutral	0.79	disease	0.68	disease	0.67	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.05	medium_impact	2.85	high_impact	0.21	0.8	60.38	10.35	0.51	N	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3941	3941	A	G	MI.12072	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	635	212	N	S	aAc/aGc	6.65	1	0	probably_damaging	1	neutral	0.42	neutral	2.67	neutral	-0.37	deleterious	-4.75	high_impact	3.73	0.65	neutral	0.1	damaging	3.22	22.70	deleterious	0.31	0.45	0.27	neutral	0.82	disease	0.64	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.2	medium_impact	2.07	high_impact	0.21	0.8	60.38	10.35	0.59	P	0.90	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3941	3941	A	C	MI.12073	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	635	212	N	T	aAc/aCc	6.65	1	0	probably_damaging	1	neutral	0.39	neutral	2.65	neutral	-0.03	deleterious	-5.71	high_impact	3.93	0.62	neutral	0.1	damaging	3.51	23.10	deleterious	0.2	0.45	0.29	neutral	0.84	disease	0.66	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.17	medium_impact	2.24	high_impact	0.24	0.8	60.38	10.35	0.58	P	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3941	3941	A	T	MI.12074	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	635	212	N	I	aAc/aTc	6.65	1	0	probably_damaging	1	neutral	0.4	neutral	2.61	neutral	0.16	deleterious	-8.56	high_impact	3.82	0.71	neutral	0.11	damaging	4.14	23.80	deleterious	0.1	0.4	0.22	neutral	0.91	disease	0.58	disease	0.68	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.18	medium_impact	2.15	high_impact	0.10	0.8	60.38	10.35	0.54	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3942	3942	C	A	MI.12075	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	636	212	N	K	aaC/aaA	5.5	1	0	probably_damaging	1	neutral	0.29	neutral	2.71	neutral	-0.71	deleterious	-5.71	high_impact	4.28	0.63	neutral	0.07	damaging	4.60	24.40	deleterious	0.22	0.45	0.29	neutral	0.84	disease	0.7	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.06	medium_impact	2.55	high_impact	0.27	0.8	60.38	10.35	0.62	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3942	3942	C	G	MI.12076	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	636	212	N	K	aaC/aaG	5.5	1	0	probably_damaging	1	neutral	0.29	neutral	2.71	neutral	-0.71	deleterious	-5.71	high_impact	4.28	0.63	neutral	0.07	damaging	4.07	23.70	deleterious	0.22	0.45	0.29	neutral	0.84	disease	0.7	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.06	medium_impact	2.55	high_impact	0.27	0.8	60.38	10.35	0.62	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3943	3943	A	G	MI.12077	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	637	213	I	V	Atc/Gtc	-3	0	0	benign	0	neutral	0.6	neutral	3.05	neutral	1.16	neutral	0.82	neutral_impact	-1.54	0.6	neutral	0.77	neutral	-1.54	0.00	neutral	0.48	0.55	0.19	neutral	0.05	neutral	0.2	neutral	0.22	neutral	6	0.39	neutral	0.8	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.37	medium_impact	-2.53	low_impact	0.54	0.8	24.21	37.99	0.42	N	0.04	polymorphism	1	0.01	rs879176055	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3943	3943	A	T	MI.12078	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	637	213	I	F	Atc/Ttc	-3	0	0	benign	0.36	neutral	0.75	neutral	2.57	neutral	-1.69	deleterious	-3.79	medium_impact	2.88	0.69	neutral	0.55	neutral	1.86	15.37	deleterious	0.07	0.35	0.38	neutral	0.76	disease	0.5	neutral	0.56	disease	1	0.25	neutral	0.7	deleterious	-3	neutral	0.42	neutral	-0.52	medium_impact	0.54	medium_impact	1.33	medium_impact	0.63	0.8	24.21	37.99	0.28	N	0.66	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3943	3943	A	C	MI.12079	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	637	213	I	L	Atc/Ctc	-3	0	0	benign	0.04	neutral	0.71	neutral	2.7	neutral	0.18	neutral	-1.89	medium_impact	2.08	0.69	neutral	0.53	neutral	1.87	15.42	deleterious	0.24	0.45	0.14	neutral	0.52	disease	0.57	disease	0.67	disease	3	0.23	neutral	0.84	deleterious	-3	neutral	0.16	neutral	0.55	medium_impact	0.49	medium_impact	0.63	medium_impact	0.74	0.85	24.21	37.99	0.31	N	0.52	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9095	9095	T	A	MI.1208	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	569	190	L	H	cTt/cAt	-7.51	0	0.01	possibly_damaging	0.9	neutral	0.16	neutral	4.11	deleterious	-4.15	deleterious	-2.63	medium_impact	3.38	0.8	neutral	0.48	neutral	4.17	23.80	deleterious	0.17	0.65	0.88	disease	0.53	disease	0.59	disease	0.68	disease	4	0.95	neutral	0.13	neutral	0	NA	0.76	deleterious	-1.66	low_impact	-0.12	medium_impact	1.8	medium_impact	0.68	0.9	18.58	14.09	0.34	N	0.84	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3944	3944	T	A	MI.12080	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	638	213	I	N	aTc/aAc	4.81	1	0	benign	0.32	neutral	0.33	neutral	2.55	neutral	-2.68	deleterious	-5.73	medium_impact	2.88	0.68	neutral	0.55	neutral	2.68	20.70	deleterious	0.04	0.35	0.54	disease	0.86	disease	0.6	disease	0.76	disease	5	0.6	neutral	0.51	deleterious	-3	neutral	0.44	deleterious	-0.44	medium_impact	0.1	medium_impact	1.33	medium_impact	0.19	0.8	24.21	37.99	0.58	P	0.85	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3944	3944	T	C	MI.12081	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	638	213	I	T	aTc/aCc	4.81	1	0	benign	0	neutral	0.4	neutral	2.69	neutral	2.25	deleterious	-2.94	neutral_impact	0.34	0.64	neutral	0.67	neutral	1.62	13.94	neutral	0.06	0.35	0.13	neutral	0.5	neutral	0.4	neutral	0.21	neutral	6	0.59	neutral	0.7	deleterious	-6	neutral	0.15	neutral	2.07	high_impact	0.18	medium_impact	-0.89	medium_impact	0.31	0.8	24.21	37.99	0.47	N	0.08	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3944	3944	T	G	MI.12082	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	638	213	I	S	aTc/aGc	4.81	1	0	benign	0.15	neutral	0.47	neutral	2.57	neutral	-1.2	deleterious	-4.79	medium_impact	2.19	0.69	neutral	0.55	neutral	2.51	19.56	deleterious	0.02	0.35	0.28	neutral	0.76	disease	0.63	disease	0.7	disease	4	0.44	neutral	0.66	deleterious	-3	neutral	0.26	neutral	-0.04	medium_impact	0.25	medium_impact	0.72	medium_impact	0.22	0.8	24.21	37.99	0.55	N	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3945	3945	C	G	MI.12083	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	639	213	I	M	atC/atG	4.58	1	0	possibly_damaging	0.56	neutral	0.22	neutral	2.58	neutral	-1.66	neutral	-1.95	medium_impact	2.88	0.6	neutral	0.48	neutral	1.65	14.15	neutral	0.14	0.4	0.37	neutral	0.53	disease	0.62	disease	0.68	disease	4	0.77	neutral	0.33	neutral	0	NA	0.39	neutral	-0.85	medium_impact	-0.03	medium_impact	1.33	medium_impact	0.70	0.85	24.21	37.99	0.66	P	0.65	polymorphism	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3945	3945	C	A	MI.12084	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	639	213	I	M	atC/atA	4.58	1	0	possibly_damaging	0.56	neutral	0.22	neutral	2.58	neutral	-1.66	neutral	-1.95	medium_impact	2.88	0.6	neutral	0.48	neutral	2.12	17.00	deleterious	0.14	0.4	0.37	neutral	0.53	disease	0.62	disease	0.68	disease	4	0.77	neutral	0.33	neutral	0	NA	0.39	neutral	-0.85	medium_impact	-0.03	medium_impact	1.33	medium_impact	0.70	0.85	24.21	37.99	0.66	P	0.65	polymorphism	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3946	3946	G	C	MI.12085	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	640	214	E	Q	Gaa/Caa	-1.85	0	0	probably_damaging	1	neutral	0.29	neutral	2.14	deleterious	-6.82	deleterious	-2.84	high_impact	4.46	0.67	neutral	0.5	neutral	3.45	23.00	deleterious	0.05	0.35	0.85	disease	0.85	disease	0.81	disease	0.67	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.06	medium_impact	2.71	high_impact	0.54	0.8	59.75	10.47	0.62	P	0.91	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3946	3946	G	A	MI.12086	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	640	214	E	K	Gaa/Aaa	-1.85	0	0	probably_damaging	1	neutral	0.29	neutral	2.16	deleterious	-6.66	deleterious	-3.79	high_impact	4.25	0.62	neutral	0.39	neutral	4.63	24.50	deleterious	0.02	0.35	0.82	disease	0.93	disease	0.81	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.06	medium_impact	2.52	high_impact	0.68	0.85	59.75	10.47	0.66	P	0.99	disease_causing_automatic	0	0.46	rs199476123	Pathogenic	Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke	24773	MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003	.	COSM1138366	.	.	G3946A	MELAS	+	+	Reported	6	P	P	P	damaging
chrM	3947	3947	A	T	MI.12087	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	641	214	E	V	gAa/gTa	8.95	1	0	probably_damaging	1	neutral	0.52	neutral	2.1	deleterious	-8.19	deleterious	-6.64	high_impact	4.8	0.63	neutral	0.42	neutral	4.39	24.10	deleterious	0.01	0.35	0.92	disease	0.93	disease	0.81	disease	0.64	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.90	deleterious	-3.57	low_impact	0.29	medium_impact	3	high_impact	0.28	0.8	59.75	10.47	0.74	P	0.83	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3947	3947	A	G	MI.12088	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	641	214	E	G	gAa/gGa	8.95	1	0	probably_damaging	1	neutral	0.35	neutral	2.12	deleterious	-7.06	deleterious	-6.64	high_impact	4.8	0.7	neutral	0.57	neutral	4.40	24.10	deleterious	0.02	0.35	0.84	disease	0.86	disease	0.8	disease	0.67	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.12	medium_impact	3	high_impact	0.09	0.8	59.75	10.47	0.76	P	0.61	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3947	3947	A	C	MI.12089	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	641	214	E	A	gAa/gCa	8.95	1	0	probably_damaging	1	neutral	0.51	neutral	2.14	deleterious	-6.89	deleterious	-5.69	high_impact	4.8	0.69	neutral	0.51	neutral	3.89	23.50	deleterious	0.02	0.35	0.84	disease	0.83	disease	0.79	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	0.29	medium_impact	3	high_impact	0.32	0.8	59.75	10.47	0.76	P	0.74	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9095	9095	T	C	MI.1209	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	569	190	L	P	cTt/cCt	-7.51	0	0.01	benign	0	neutral	0.06	neutral	4.13	deleterious	-3.22	neutral	-1.63	low_impact	1.18	0.96	neutral	0.72	neutral	0.97	10.52	neutral	0.14	0.65	0.88	disease	0.71	disease	0.64	disease	0.74	disease	5	0.94	neutral	0.53	deleterious	-6	neutral	0.32	neutral	2.09	high_impact	-0.38	medium_impact	-0.09	medium_impact	0.66	0.9	18.58	14.09	0.34	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	COSM1138415	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3948	3948	A	T	MI.12090	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	642	214	E	D	gaA/gaT	8.49	1	0	probably_damaging	1	neutral	0.2	neutral	2.21	deleterious	-4.9	deleterious	-2.85	high_impact	3.77	0.75	neutral	0.5	neutral	3.88	23.50	deleterious	0.07	0.35	0.71	disease	0.84	disease	0.74	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.06	medium_impact	2.1	high_impact	0.62	0.8	59.75	10.47	0.71	P	0.90	polymorphism	0.98	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3948	3948	A	C	MI.12091	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	642	214	E	D	gaA/gaC	8.49	1	0	probably_damaging	1	neutral	0.2	neutral	2.21	deleterious	-4.9	deleterious	-2.85	high_impact	3.77	0.75	neutral	0.5	neutral	3.78	23.40	deleterious	0.07	0.35	0.71	disease	0.84	disease	0.74	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.06	medium_impact	2.1	high_impact	0.62	0.8	59.75	10.47	0.7	P	0.90	polymorphism	0.98	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3949	3949	T	A	MI.12092	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	643	215	Y	N	Tac/Aac	-0.01	0.92	0	probably_damaging	1	neutral	0.31	neutral	2.02	deleterious	-7.87	deleterious	-8.52	high_impact	4.72	0.68	neutral	0.39	neutral	4.35	24.10	deleterious	0.02	0.35	0.66	disease	0.91	disease	0.72	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.08	medium_impact	2.93	high_impact	0.14	0.8	59.75	10.42	0.61	P	1.00	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3949	3949	T	C	MI.12093	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	643	215	Y	H	Tac/Cac	-0.01	0.92	0	probably_damaging	1	neutral	0.54	neutral	2.03	deleterious	-5.18	deleterious	-4.74	medium_impact	3.48	0.58	damaging	0.3	neutral	3.75	23.30	deleterious	0.05	0.35	0.59	disease	0.86	disease	0.82	disease	0.72	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.84	deleterious	-3.57	low_impact	0.31	medium_impact	1.85	medium_impact	0.20	0.8	59.75	10.42	0.54	P	1.00	disease_causing_automatic	0	0.23	rs199476124	Pathogenic	Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke	24774	MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003	thyroid oncocytoma	.	.	.	T3949C	MELAS	-	+	Reported	6	P	P	P	damaging
chrM	3949	3949	T	G	MI.12094	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	643	215	Y	D	Tac/Gac	-0.01	0.92	0	probably_damaging	1	neutral	0.2	neutral	2.01	deleterious	-8.79	deleterious	-9.47	high_impact	4.72	0.71	neutral	0.35	neutral	4.11	23.80	deleterious	0.02	0.35	0.72	disease	0.91	disease	0.81	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.06	medium_impact	2.93	high_impact	0.11	0.8	59.75	10.42	0.63	P	1.00	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3950	3950	A	G	MI.12095	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	644	215	Y	C	tAc/tGc	7.34	1	0	probably_damaging	1	neutral	0.17	neutral	2.01	deleterious	-8.8	deleterious	-8.53	high_impact	4.38	0.72	neutral	0.28	damaging	3.58	23.20	deleterious	0.02	0.35	0.78	disease	0.91	disease	0.79	disease	0.66	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.11	medium_impact	2.64	high_impact	0.15	0.8	59.75	10.42	0.65	P	1.00	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3950	3950	A	C	MI.12096	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	644	215	Y	S	tAc/tCc	7.34	1	0	probably_damaging	1	neutral	0.42	neutral	2.03	deleterious	-7.27	deleterious	-8.52	high_impact	4.72	0.65	neutral	0.46	neutral	3.75	23.30	deleterious	0.03	0.35	0.54	disease	0.9	disease	0.74	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.2	medium_impact	2.93	high_impact	0.16	0.8	59.75	10.42	0.67	P	1.00	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3950	3950	A	T	MI.12097	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	644	215	Y	F	tAc/tTc	7.34	1	0	probably_damaging	1	neutral	0.71	neutral	2.2	deleterious	-3.96	deleterious	-3.79	medium_impact	2.4	0.63	neutral	0.42	neutral	3.42	23.00	deleterious	0.1	0.4	0.41	neutral	0.84	disease	0.66	disease	0.33	neutral	3	1	deleterious	0.36	neutral	1	deleterious	0.81	deleterious	-3.57	low_impact	0.49	medium_impact	0.91	medium_impact	0.33	0.8	59.75	10.42	0.53	N	0.80	polymorphism	0.99	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3952	3952	G	C	MI.12098	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	646	216	A	P	Gcc/Ccc	-5.98	0	0	probably_damaging	0.98	neutral	0.2	neutral	2.52	neutral	-2.53	deleterious	-4.64	high_impact	3.53	0.72	neutral	0.36	neutral	3.99	23.60	deleterious	0.03	0.35	0.64	disease	0.94	disease	0.59	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-2.34	low_impact	-0.06	medium_impact	1.89	medium_impact	0.46	0.8	54.4	8.49	0.36	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3952	3952	G	T	MI.12099	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	646	216	A	S	Gcc/Tcc	-5.98	0	0	benign	0.33	neutral	0.43	neutral	2.97	neutral	2.88	deleterious	-2.62	neutral_impact	0.36	0.73	neutral	0.61	neutral	3.76	23.30	deleterious	0.16	0.45	0.15	neutral	0.39	neutral	0.23	neutral	0.42	neutral	2	0.49	neutral	0.55	deleterious	-6	neutral	0.33	neutral	-0.46	medium_impact	0.21	medium_impact	-0.87	medium_impact	0.29	0.8	54.4	8.49	0.37	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8582	8582	C	T	MI.121	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	56	19	A	V	gCc/gTc	-0.57	0	0	probably_damaging	1	deleterious	0.04	neutral	4.73	neutral	0.47	neutral	1.01	neutral_impact	-0.24	0.95	neutral	0.93	neutral	3.11	22.50	deleterious	0.33	0.65	0.26	neutral	0.55	disease	0.39	neutral	0.48	neutral	0	1	deleterious	0.02	neutral	2	deleterious	0.70	deleterious	-3.6	low_impact	-0.49	medium_impact	-1.3	low_impact	0.58	0.9	29.65	29.28	0.44	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9095	9095	T	G	MI.1210	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	569	190	L	R	cTt/cGt	-7.51	0	0.01	possibly_damaging	0.8	neutral	0.11	neutral	4.12	deleterious	-3.57	neutral	-2.13	medium_impact	3.03	0.78	neutral	0.42	neutral	4.06	23.70	deleterious	0.11	0.65	0.84	disease	0.71	disease	0.7	disease	0.77	disease	5	0.93	neutral	0.16	neutral	0	NA	0.76	deleterious	-1.33	low_impact	-0.22	medium_impact	1.5	medium_impact	0.74	0.9	18.58	14.09	0.29	N	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3952	3952	G	A	MI.12100	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	646	216	A	T	Gcc/Acc	-5.98	0	0	probably_damaging	0.91	neutral	0.39	neutral	2.56	neutral	-0.58	deleterious	-3.65	medium_impact	2.6	0.65	neutral	0.47	neutral	4.44	24.20	deleterious	0.13	0.4	0.22	neutral	0.84	disease	0.29	neutral	0.45	neutral	1	0.91	neutral	0.24	neutral	1	deleterious	0.69	deleterious	-1.69	low_impact	0.17	medium_impact	1.08	medium_impact	0.56	0.8	54.4	8.49	0.38	N	0.70	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3953	3953	C	G	MI.12101	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	647	216	A	G	gCc/gGc	2.98	0.99	0	possibly_damaging	0.86	neutral	0.35	neutral	2.54	neutral	-0.12	deleterious	-3.67	low_impact	1.61	0.71	neutral	0.46	neutral	4.13	23.80	deleterious	0.15	0.4	0.27	neutral	0.8	disease	0.26	neutral	0.19	neutral	6	0.87	neutral	0.25	neutral	-3	neutral	0.67	deleterious	-1.49	low_impact	0.12	medium_impact	0.22	medium_impact	0.50	0.8	54.4	8.49	0.51	N	0.79	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3953	3953	C	A	MI.12102	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	647	216	A	D	gCc/gAc	2.98	0.99	0	probably_damaging	0.96	neutral	0.2	neutral	2.51	neutral	-1.91	deleterious	-5.51	high_impact	3.88	0.74	neutral	0.32	neutral	4.65	24.50	deleterious	0.03	0.35	0.66	disease	0.94	disease	0.71	disease	0.8	disease	6	0.97	neutral	0.12	neutral	2	deleterious	0.84	deleterious	-2.05	low_impact	-0.06	medium_impact	2.2	high_impact	0.27	0.8	54.4	8.49	0.59	P	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3953	3953	C	T	MI.12103	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	647	216	A	V	gCc/gTc	2.98	0.99	0	probably_damaging	0.94	neutral	0.52	neutral	2.52	neutral	-1.44	deleterious	-3.77	high_impact	3.53	0.73	neutral	0.4	neutral	4.64	24.50	deleterious	0.07	0.35	0.55	disease	0.9	disease	0.61	disease	0.7	disease	4	0.93	neutral	0.29	neutral	2	deleterious	0.78	deleterious	-1.87	low_impact	0.29	medium_impact	1.89	medium_impact	0.50	0.8	54.4	8.49	0.52	N	0.72	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3955	3955	G	C	MI.12104	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	649	217	A	P	Gca/Cca	-4.38	0	0	probably_damaging	1	neutral	0.2	neutral	2.66	deleterious	-3.58	deleterious	-3.1	medium_impact	3.31	0.66	neutral	0.1	damaging	4.03	23.60	deleterious	0.04	0.35	0.61	disease	0.94	disease	0.59	disease	0.79	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.88	deleterious	-3.57	low_impact	-0.06	medium_impact	1.7	medium_impact	0.44	0.8	55.35	10.3	0.32	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3955	3955	G	T	MI.12105	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	649	217	A	S	Gca/Tca	-4.38	0	0	probably_damaging	1	neutral	0.41	neutral	2.9	neutral	0.7	neutral	-1.18	low_impact	1.04	0.81	neutral	0.18	damaging	3.84	23.40	deleterious	0.1	0.4	0.17	neutral	0.5	neutral	0.2	neutral	0.31	neutral	4	1	deleterious	0.21	neutral	-2	neutral	0.72	deleterious	-3.57	low_impact	0.19	medium_impact	-0.28	medium_impact	0.40	0.8	55.35	10.3	0.32	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3955	3955	G	A	MI.12106	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	649	217	A	T	Gca/Aca	-4.38	0	0	probably_damaging	1	neutral	0.39	neutral	2.73	neutral	-2.14	deleterious	-2.68	high_impact	3.65	0.68	neutral	0.15	damaging	4.36	24.10	deleterious	0.06	0.35	0.4	neutral	0.78	disease	0.6	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.17	medium_impact	2	medium_impact	0.52	0.8	55.35	10.3	0.34	N	0.70	polymorphism	1	0.20	rs28552781	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3956	3956	C	G	MI.12107	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	650	217	A	G	gCa/gGa	5.04	0.99	0	probably_damaging	1	neutral	0.35	neutral	2.86	neutral	2.88	neutral	1.65	neutral_impact	-0.24	0.8	neutral	0.93	neutral	1.37	12.65	neutral	0.09	0.35	0.16	neutral	0.21	neutral	0.24	neutral	0.36	neutral	3	1	deleterious	0.18	neutral	-2	neutral	0.67	deleterious	-3.57	low_impact	0.12	medium_impact	-1.4	low_impact	0.38	0.8	55.35	10.3	0.52	P	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3956	3956	C	T	MI.12108	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	650	217	A	V	gCa/gTa	5.04	0.99	0	probably_damaging	1	neutral	0.51	neutral	2.68	deleterious	-3	deleterious	-3.24	high_impact	3.65	0.69	neutral	0.13	damaging	4.62	24.50	deleterious	0.06	0.35	0.52	disease	0.86	disease	0.61	disease	0.74	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.29	medium_impact	2	medium_impact	0.44	0.8	55.35	10.3	0.57	P	0.72	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3956	3956	C	A	MI.12109	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	650	217	A	E	gCa/gAa	5.04	0.99	0	probably_damaging	1	neutral	0.29	neutral	2.71	neutral	-2.82	deleterious	-3.09	medium_impact	3.31	0.7	neutral	0.1	damaging	4.62	24.50	deleterious	0.03	0.35	0.48	neutral	0.91	disease	0.72	disease	0.76	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.84	deleterious	-3.57	low_impact	0.06	medium_impact	1.7	medium_impact	0.27	0.8	55.35	10.3	0.57	P	0.96	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9097	9097	A	G	MI.1211	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	571	191	I	V	Atc/Gtc	-8.2	0	0	probably_damaging	0.93	neutral	0.19	neutral	4.47	neutral	0.18	neutral	-0.45	low_impact	0.88	0.9	neutral	0.94	neutral	1.92	15.69	deleterious	0.58	0.7	0.32	neutral	0.19	neutral	0.35	neutral	0.37	neutral	3	0.96	neutral	0.13	neutral	-2	neutral	0.60	deleterious	-1.82	low_impact	-0.06	medium_impact	-0.34	medium_impact	0.54	0.9	19.47	23.84	0.48	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3958	3958	G	A	MI.12110	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	652	218	G	S	Ggc/Agc	-2.77	0	0	probably_damaging	1	neutral	0.41	neutral	2.74	neutral	0.25	deleterious	-5.61	medium_impact	2.5	0.33	damaging	0.03	damaging	4.30	24.00	deleterious	0.14	0.4	0.18	neutral	0.85	disease	0.49	neutral	0.47	neutral	1	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.19	medium_impact	1	medium_impact	0.74	0.85	60.38	10.42	0.52	P	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	G3958A	LHON	+	-	Reported	1	.	P	P	damaging
chrM	3958	3958	G	T	MI.12111	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	652	218	G	C	Ggc/Tgc	-2.77	0	0	probably_damaging	1	neutral	0.17	neutral	2.69	neutral	-2.03	deleterious	-8.49	high_impact	4.25	0.46	damaging	0.01	damaging	4.29	24.00	deleterious	0.06	0.35	0.51	disease	0.93	disease	0.62	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.11	medium_impact	2.52	high_impact	0.17	0.8	60.38	10.42	0.42	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3958	3958	G	C	MI.12112	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	652	218	G	R	Ggc/Cgc	-2.77	0	0	probably_damaging	1	neutral	0.34	neutral	2.72	neutral	0.4	deleterious	-7.55	high_impact	4.25	0.47	damaging	0.02	damaging	4.11	23.70	deleterious	0.06	0.35	0.37	neutral	0.93	disease	0.7	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.11	medium_impact	2.52	high_impact	0.57	0.8	60.38	10.42	0.43	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3959	3959	G	A	MI.12113	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	653	218	G	D	gGc/gAc	5.96	1	0	probably_damaging	1	neutral	0.2	neutral	2.7	neutral	-1.56	deleterious	-6.59	high_impact	4.25	0.45	damaging	0.02	damaging	4.04	23.70	deleterious	0.04	0.35	0.47	neutral	0.91	disease	0.69	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.06	medium_impact	2.52	high_impact	0.17	0.8	60.38	10.42	0.72	P	1.00	polymorphism	1	0.28	.	.	.	.	.	.	COSM6716692	.	.	G3959A	MELAS	.	.	Reported	1	.	P	P	damaging
chrM	3959	3959	G	C	MI.12114	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	653	218	G	A	gGc/gCc	5.96	1	0	probably_damaging	1	neutral	0.5	neutral	2.77	neutral	0.42	deleterious	-5.64	medium_impact	2.9	0.38	damaging	0.05	damaging	3.26	22.80	deleterious	0.18	0.45	0.18	neutral	0.72	disease	0.48	neutral	0.22	neutral	6	1	deleterious	0.25	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.28	medium_impact	1.34	medium_impact	0.33	0.8	60.38	10.42	0.61	P	0.76	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3959	3959	G	T	MI.12115	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	653	218	G	V	gGc/gTc	5.96	1	0	probably_damaging	1	neutral	0.52	neutral	2.84	neutral	1.01	deleterious	-8.5	medium_impact	2.32	0.42	damaging	0.02	damaging	3.90	23.50	deleterious	0.09	0.35	0.15	neutral	0.91	disease	0.63	disease	0.69	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.29	medium_impact	0.84	medium_impact	0.15	0.8	60.38	10.42	0.49	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3961	3961	C	A	MI.12116	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	655	219	P	T	Ccc/Acc	-20	0	0	possibly_damaging	0.64	neutral	0.38	neutral	2.74	neutral	0	deleterious	-7.2	medium_impact	2.69	0.67	neutral	0.36	neutral	3.79	23.40	deleterious	0.13	0.4	0.2	neutral	0.84	disease	0.3	neutral	0.49	neutral	0	0.68	neutral	0.37	neutral	0	NA	0.56	deleterious	-0.99	medium_impact	0.16	medium_impact	1.16	medium_impact	0.59	0.8	50.31	10.14	0.37	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3961	3961	C	G	MI.12117	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	655	219	P	A	Ccc/Gcc	-20	0	0	benign	0.39	neutral	0.5	neutral	2.81	neutral	0.6	deleterious	-7.2	medium_impact	2.31	0.74	neutral	0.44	neutral	3.16	22.60	deleterious	0.15	0.4	0.15	neutral	0.71	disease	0.45	neutral	0.37	neutral	3	0.44	neutral	0.56	deleterious	-3	neutral	0.41	neutral	-0.57	medium_impact	0.28	medium_impact	0.83	medium_impact	0.61	0.8	50.31	10.14	0.32	N	0.78	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3961	3961	C	T	MI.12118	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	655	219	P	S	Ccc/Tcc	-20	0	0	benign	0.08	neutral	0.41	neutral	2.76	neutral	0.5	deleterious	-7.11	low_impact	1.7	0.72	neutral	0.66	neutral	3.98	23.60	deleterious	0.18	0.45	0.17	neutral	0.78	disease	0.28	neutral	0.21	neutral	6	0.54	neutral	0.67	deleterious	-6	neutral	0.21	neutral	0.25	medium_impact	0.19	medium_impact	0.3	medium_impact	0.20	0.8	50.31	10.14	0.44	N	0.74	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3962	3962	C	G	MI.12119	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	656	219	P	R	cCc/cGc	7.11	1	0	probably_damaging	0.9	neutral	0.34	neutral	2.74	neutral	1.07	deleterious	-8.15	medium_impact	1.96	0.72	neutral	0.36	neutral	3.77	23.40	deleterious	0.09	0.35	0.12	neutral	0.94	disease	0.62	disease	0.75	disease	5	0.91	neutral	0.22	neutral	1	deleterious	0.72	deleterious	-1.65	low_impact	0.11	medium_impact	0.52	medium_impact	0.38	0.8	50.31	10.14	0.48	N	0.71	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9097	9097	A	C	MI.1212	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	571	191	I	L	Atc/Ctc	-8.2	0	0	probably_damaging	0.93	neutral	1	neutral	4.53	neutral	0.1	neutral	-0.29	neutral_impact	-0.52	0.83	neutral	0.87	neutral	1.16	11.52	neutral	0.34	0.65	0.33	neutral	0.12	neutral	0.23	neutral	0.28	neutral	4	0.93	neutral	0.54	deleterious	-2	neutral	0.59	deleterious	-1.82	low_impact	1.98	high_impact	-1.54	low_impact	0.62	0.9	19.47	23.84	0.25	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3962	3962	C	A	MI.12120	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	656	219	P	H	cCc/cAc	7.11	1	0	probably_damaging	0.96	neutral	0.53	neutral	2.69	neutral	-0.8	deleterious	-8.14	medium_impact	3.12	0.72	neutral	0.3	neutral	4.20	23.90	deleterious	0.08	0.35	0.28	neutral	0.87	disease	0.42	neutral	0.66	disease	3	0.96	neutral	0.29	neutral	1	deleterious	0.74	deleterious	-2.05	low_impact	0.3	medium_impact	1.54	medium_impact	0.33	0.8	50.31	10.14	0.5	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3962	3962	C	T	MI.12121	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	656	219	P	L	cCc/cTc	7.11	1	0	possibly_damaging	0.81	neutral	0.65	neutral	2.71	neutral	0.14	deleterious	-9.12	medium_impact	2.14	0.72	neutral	0.38	neutral	4.57	24.40	deleterious	0.13	0.4	0.27	neutral	0.91	disease	0.44	neutral	0.49	neutral	0	0.78	neutral	0.42	neutral	0	NA	0.70	deleterious	-1.34	low_impact	0.43	medium_impact	0.68	medium_impact	0.64	0.8	50.31	10.14	0.48	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3964	3964	T	G	MI.12122	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	658	220	F	V	Ttc/Gtc	-8.05	0	0	probably_damaging	1	neutral	0.51	neutral	2.25	deleterious	-3.39	deleterious	-6.64	high_impact	4.41	0.64	neutral	0.51	neutral	4.29	24.00	deleterious	0.05	0.35	0.43	neutral	0.88	disease	0.73	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.29	medium_impact	2.66	high_impact	0.28	0.8	59.75	10.29	0.48	N	0.98	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3964	3964	T	A	MI.12123	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	658	220	F	I	Ttc/Atc	-8.05	0	0	probably_damaging	1	neutral	0.39	neutral	2.24	deleterious	-3.59	deleterious	-5.69	high_impact	4.21	0.71	neutral	0.6	neutral	4.55	24.30	deleterious	0.09	0.35	0.47	neutral	0.87	disease	0.73	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.17	medium_impact	2.49	high_impact	0.42	0.8	59.75	10.29	0.51	N	0.97	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3964	3964	T	C	MI.12124	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	658	220	F	L	Ttc/Ctc	-8.05	0	0	probably_damaging	1	neutral	0.65	neutral	2.3	neutral	-2.58	deleterious	-5.68	high_impact	3.72	0.62	neutral	0.56	neutral	4.20	23.90	deleterious	0.12	0.4	0.26	neutral	0.85	disease	0.62	disease	0.7	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.43	medium_impact	2.06	high_impact	0.55	0.8	59.75	10.29	0.46	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3965	3965	T	C	MI.12125	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	659	220	F	S	tTc/tCc	7.34	1	0	probably_damaging	1	neutral	0.42	neutral	2.24	deleterious	-3.59	deleterious	-7.59	high_impact	4.41	0.72	neutral	0.66	neutral	4.39	24.10	deleterious	0.02	0.35	0.51	disease	0.87	disease	0.72	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.2	medium_impact	2.66	high_impact	0.23	0.8	59.75	10.29	0.7	P	0.98	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3965	3965	T	G	MI.12126	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	659	220	F	C	tTc/tGc	7.34	1	0	probably_damaging	1	neutral	0.17	neutral	2.19	deleterious	-5.89	deleterious	-7.59	high_impact	4.76	0.7	neutral	0.49	neutral	4.26	23.90	deleterious	0.02	0.35	0.78	disease	0.88	disease	0.67	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.11	medium_impact	2.97	high_impact	0.20	0.8	59.75	10.29	0.7	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3965	3965	T	A	MI.12127	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	659	220	F	Y	tTc/tAc	7.34	1	0	probably_damaging	1	neutral	1	neutral	2.42	neutral	-1.56	deleterious	-2.85	medium_impact	3.38	0.7	neutral	0.46	neutral	4.39	24.10	deleterious	0.12	0.4	0.4	neutral	0.82	disease	0.68	disease	0.68	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.77	deleterious	-3.57	low_impact	1.96	high_impact	1.76	medium_impact	0.55	0.8	59.75	10.29	0.55	P	0.88	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3966	3966	C	G	MI.12128	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	660	220	F	L	ttC/ttG	5.73	1	0	probably_damaging	1	neutral	0.65	neutral	2.3	neutral	-2.58	deleterious	-5.68	high_impact	3.72	0.62	neutral	0.56	neutral	4.46	24.20	deleterious	0.12	0.4	0.26	neutral	0.85	disease	0.62	disease	0.7	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.43	medium_impact	2.06	high_impact	0.55	0.8	59.75	10.29	0.57	P	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3966	3966	C	A	MI.12129	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	660	220	F	L	ttC/ttA	5.73	1	0	probably_damaging	1	neutral	0.65	neutral	2.3	neutral	-2.58	deleterious	-5.68	high_impact	3.72	0.62	neutral	0.56	neutral	4.79	24.70	deleterious	0.12	0.4	0.26	neutral	0.85	disease	0.62	disease	0.7	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.43	medium_impact	2.06	high_impact	0.55	0.8	59.75	10.29	0.57	P	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9097	9097	A	T	MI.1213	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	571	191	I	F	Atc/Ttc	-8.2	0	0	probably_damaging	0.99	neutral	0.37	neutral	4.37	neutral	-1.73	neutral	-2.46	low_impact	1.17	0.86	neutral	0.49	neutral	3.79	23.40	deleterious	0.32	0.65	0.43	neutral	0.55	disease	0.36	neutral	0.48	neutral	0	0.99	deleterious	0.19	neutral	-2	neutral	0.71	deleterious	-2.65	low_impact	0.16	medium_impact	-0.1	medium_impact	0.71	0.9	19.47	23.84	0.27	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3967	3967	G	T	MI.12130	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	661	221	A	S	Gcc/Tcc	-2.77	0	0	probably_damaging	1	neutral	0.46	neutral	2.53	neutral	-2.82	deleterious	-2.79	medium_impact	2.94	0.74	neutral	0.09	damaging	3.85	23.40	deleterious	0.12	0.4	0.49	neutral	0.87	disease	0.51	disease	0.68	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	0.24	medium_impact	1.38	medium_impact	0.37	0.8	59.12	10.43	0.26	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3967	3967	G	C	MI.12131	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	661	221	A	P	Gcc/Ccc	-2.77	0	0	probably_damaging	1	neutral	0.19	neutral	2.46	deleterious	-4.81	deleterious	-4.69	high_impact	4	0.71	neutral	0.07	damaging	3.96	23.60	deleterious	0.02	0.35	0.74	disease	0.9	disease	0.75	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.08	medium_impact	2.31	high_impact	0.40	0.8	59.12	10.43	0.37	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3967	3967	G	A	MI.12132	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	661	221	A	T	Gcc/Acc	-2.77	0	0	probably_damaging	1	neutral	0.35	neutral	2.53	deleterious	-3.02	deleterious	-3.66	medium_impact	2.64	0.77	neutral	0.13	damaging	4.37	24.10	deleterious	0.09	0.35	0.53	disease	0.87	disease	0.51	disease	0.39	neutral	2	1	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	0.12	medium_impact	1.12	medium_impact	0.71	0.85	59.12	10.43	0.33	N	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3968	3968	C	A	MI.12133	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	662	221	A	D	gCc/gAc	5.04	1	0	probably_damaging	1	neutral	0.18	neutral	2.47	deleterious	-3.9	deleterious	-5.63	high_impact	4.54	0.8	neutral	0.09	damaging	4.66	24.50	deleterious	0.02	0.35	0.74	disease	0.93	disease	0.75	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.09	medium_impact	2.78	high_impact	0.27	0.8	59.12	10.43	0.64	P	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3968	3968	C	G	MI.12134	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	662	221	A	G	gCc/gGc	5.04	1	0	probably_damaging	1	neutral	0.45	neutral	2.52	neutral	-0.8	deleterious	-3.77	medium_impact	2.48	0.76	neutral	0.11	damaging	4.15	23.80	deleterious	0.13	0.4	0.26	neutral	0.84	disease	0.57	disease	0.68	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.23	medium_impact	0.98	medium_impact	0.58	0.8	59.12	10.43	0.48	N	0.79	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3968	3968	C	T	MI.12135	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	662	221	A	V	gCc/gTc	5.04	1	0	probably_damaging	1	neutral	0.48	neutral	2.57	neutral	-2.27	deleterious	-3.73	medium_impact	2.58	0.76	neutral	0.12	damaging	4.63	24.50	deleterious	0.05	0.35	0.4	neutral	0.87	disease	0.55	disease	0.58	disease	2	1	deleterious	0.24	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.26	medium_impact	1.07	medium_impact	0.62	0.8	59.12	10.43	0.5	N	0.72	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3970	3970	C	A	MI.12136	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	664	222	L	M	Cta/Ata	-3.69	0	0.15	probably_damaging	1	neutral	0.22	neutral	1.92	deleterious	-3.65	neutral	-1.74	low_impact	1.65	0.85	neutral	0.84	neutral	2.78	21.30	deleterious	0.18	0.45	0.47	neutral	0.51	disease	0.27	neutral	0.38	neutral	2	1	deleterious	0.11	neutral	-2	neutral	0.71	deleterious	-3.57	low_impact	-0.03	medium_impact	0.25	medium_impact	0.51	0.8	42.45	12.47	0.41	N	0.27	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3970	3970	C	G	MI.12137	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	664	222	L	V	Cta/Gta	-3.69	0	0.15	probably_damaging	1	neutral	0.49	neutral	1.93	deleterious	-3.52	deleterious	-2.79	medium_impact	2.9	0.67	neutral	0.15	damaging	3.52	23.10	deleterious	0.16	0.45	0.45	neutral	0.7	disease	0.59	disease	0.65	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.27	medium_impact	1.34	medium_impact	0.51	0.8	42.45	12.47	0.24	N	0.69	polymorphism	1	0.11	rs9629042	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	3971	3971	T	C	MI.12138	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	665	222	L	P	cTa/cCa	-0.7	0	0	probably_damaging	1	neutral	0.2	neutral	1.82	deleterious	-7.07	deleterious	-6.55	medium_impact	3.5	0.76	neutral	0.15	damaging	4.02	23.60	deleterious	0.02	0.35	0.9	disease	0.85	disease	0.71	disease	0.75	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.87	deleterious	-3.57	low_impact	-0.06	medium_impact	1.87	medium_impact	0.28	0.8	42.45	12.47	0.29	N	0.92	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3971	3971	T	A	MI.12139	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	665	222	L	Q	cTa/cAa	-0.7	0	0	probably_damaging	1	neutral	0.29	neutral	1.82	deleterious	-6.39	deleterious	-5.57	high_impact	4.12	0.72	neutral	0.14	damaging	4.17	23.80	deleterious	0.03	0.35	0.87	disease	0.82	disease	0.6	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.06	medium_impact	2.41	high_impact	0.35	0.8	42.45	12.47	0.36	N	0.94	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9098	9098	T	G	MI.1214	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	572	191	I	S	aTc/aGc	-1.26	0	0	probably_damaging	0.99	neutral	0.1	neutral	4.28	neutral	-1.48	deleterious	-2.99	medium_impact	1.94	0.89	neutral	0.49	neutral	4.31	24.00	deleterious	0.23	0.65	0.71	disease	0.59	disease	0.58	disease	0.57	disease	1	1	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	-0.25	medium_impact	0.57	medium_impact	0.68	0.9	19.47	23.84	0.43	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3971	3971	T	G	MI.12140	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	665	222	L	R	cTa/cGa	-0.7	0	0	probably_damaging	1	neutral	0.34	neutral	1.82	deleterious	-6.45	deleterious	-5.6	high_impact	4.47	0.74	neutral	0.12	damaging	4.30	24.00	deleterious	0.02	0.35	0.87	disease	0.92	disease	0.72	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-3.57	low_impact	0.11	medium_impact	2.72	high_impact	0.21	0.8	42.45	12.47	0.44	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3973	3973	T	A	MI.12141	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	667	223	F	I	Ttc/Atc	-2.31	0	0	benign	0.24	neutral	0.4	neutral	2.62	neutral	-1.89	deleterious	-5.3	medium_impact	2	0.72	neutral	0.6	neutral	2.57	19.90	deleterious	0.14	0.4	0.28	neutral	0.63	disease	0.3	neutral	0.42	neutral	2	0.52	neutral	0.58	deleterious	-3	neutral	0.30	neutral	-0.28	medium_impact	0.18	medium_impact	0.56	medium_impact	0.42	0.8	59.43	10.3	0.38	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3973	3973	T	G	MI.12142	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	667	223	F	V	Ttc/Gtc	-2.31	0	0	benign	0.35	neutral	0.49	neutral	2.59	neutral	-2.1	deleterious	-6.22	medium_impact	3.33	0.66	neutral	0.5	neutral	2.23	17.71	deleterious	0.08	0.35	0.29	neutral	0.9	disease	0.62	disease	0.72	disease	4	0.43	neutral	0.57	deleterious	-3	neutral	0.35	neutral	-0.5	medium_impact	0.27	medium_impact	1.72	medium_impact	0.33	0.8	59.43	10.3	0.36	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3973	3973	T	C	MI.12143	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	667	223	F	L	Ttc/Ctc	-2.31	0	0	benign	0.02	neutral	0.65	neutral	2.71	neutral	-1.55	deleterious	-5.24	low_impact	1.5	0.68	neutral	0.58	neutral	2.16	17.27	deleterious	0.16	0.45	0.2	neutral	0.78	disease	0.34	neutral	0.5	neutral	0	0.32	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.84	medium_impact	0.43	medium_impact	0.12	medium_impact	0.48	0.8	59.43	10.3	0.32	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3974	3974	T	G	MI.12144	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	668	223	F	C	tTc/tGc	5.73	1	0	probably_damaging	0.92	neutral	0.17	neutral	2.46	deleterious	-5.1	deleterious	-7.18	high_impact	4.43	0.71	neutral	0.49	neutral	3.78	23.40	deleterious	0.03	0.35	0.66	disease	0.91	disease	0.65	disease	0.73	disease	5	0.96	neutral	0.13	neutral	2	deleterious	0.77	deleterious	-1.75	low_impact	-0.11	medium_impact	2.68	high_impact	0.27	0.8	59.43	10.3	0.67	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3974	3974	T	C	MI.12145	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	668	223	F	S	tTc/tCc	5.73	1	0	possibly_damaging	0.74	neutral	0.43	neutral	2.51	deleterious	-3.58	deleterious	-7.2	high_impact	4.08	0.7	neutral	0.62	neutral	2.57	19.89	deleterious	0.02	0.35	0.46	neutral	0.88	disease	0.63	disease	0.71	disease	4	0.74	neutral	0.35	neutral	1	deleterious	0.66	deleterious	-1.18	low_impact	0.21	medium_impact	2.38	high_impact	0.37	0.8	59.43	10.3	0.69	P	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3974	3974	T	A	MI.12146	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	668	223	F	Y	tTc/tAc	5.73	1	0	possibly_damaging	0.59	neutral	1	neutral	2.5	neutral	-2.95	deleterious	-2.71	medium_impact	3.27	0.72	neutral	0.46	neutral	2.68	20.70	deleterious	0.16	0.45	0.38	neutral	0.84	disease	0.64	disease	0.7	disease	4	0.59	neutral	0.71	deleterious	0	NA	0.52	deleterious	-0.9	medium_impact	1.96	high_impact	1.67	medium_impact	0.53	0.8	59.43	10.3	0.56	N	0.88	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3975	3975	C	G	MI.12147	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	669	223	F	L	ttC/ttG	7.34	1	0	benign	0.02	neutral	0.65	neutral	2.71	neutral	-1.55	deleterious	-5.24	low_impact	1.5	0.68	neutral	0.58	neutral	2.51	19.53	deleterious	0.16	0.45	0.2	neutral	0.78	disease	0.34	neutral	0.5	neutral	0	0.32	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.84	medium_impact	0.43	medium_impact	0.12	medium_impact	0.48	0.8	59.43	10.3	0.53	P	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3975	3975	C	A	MI.12148	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	669	223	F	L	ttC/ttA	7.34	1	0	benign	0.02	neutral	0.65	neutral	2.71	neutral	-1.55	deleterious	-5.24	low_impact	1.5	0.68	neutral	0.58	neutral	2.79	21.30	deleterious	0.16	0.45	0.2	neutral	0.78	disease	0.34	neutral	0.5	neutral	0	0.32	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.84	medium_impact	0.43	medium_impact	0.12	medium_impact	0.48	0.8	59.43	10.3	0.53	P	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3976	3976	T	G	MI.12149	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	670	224	F	V	Ttc/Gtc	-4.84	0	0	probably_damaging	1	neutral	0.5	neutral	2.47	neutral	-2.31	deleterious	-6.31	high_impact	4.19	0.63	neutral	0.13	damaging	4.12	23.80	deleterious	0.06	0.35	0.3	neutral	0.9	disease	0.7	disease	0.75	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	0.28	medium_impact	2.47	high_impact	0.26	0.8	59.43	10.39	0.36	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9098	9098	T	C	MI.1215	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	572	191	I	T	aTc/aCc	-1.26	0	0	probably_damaging	0.99	neutral	0.07	neutral	4.3	neutral	-2.03	neutral	-1.86	low_impact	1.4	0.89	neutral	0.92	neutral	2.36	18.53	deleterious	0.39	0.65	0.65	disease	0.32	neutral	0.39	neutral	0.62	disease	2	1	deleterious	0.04	neutral	-2	neutral	0.72	deleterious	-2.65	low_impact	-0.34	medium_impact	0.1	medium_impact	0.66	0.9	19.47	23.84	0.54	N	1.00	polymorphism	1	0.03	rs201559119	.	.	.	.	.	.	.	.	T9098C	Predisposition to anti-retroviral mito disease	+	-	Reported	1	N	P	N,P	neutral
chrM	3976	3976	T	C	MI.12150	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	670	224	F	L	Ttc/Ctc	-4.84	0	0	probably_damaging	1	neutral	0.67	neutral	2.5	neutral	-1.86	deleterious	-5.41	high_impact	3.54	0.65	neutral	0.13	damaging	4.07	23.70	deleterious	0.11	0.4	0.25	neutral	0.85	disease	0.66	disease	0.72	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.45	medium_impact	1.9	medium_impact	0.60	0.8	59.43	10.39	0.37	N	0.92	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3976	3976	T	A	MI.12151	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	670	224	F	I	Ttc/Atc	-4.84	0	0	probably_damaging	1	neutral	0.4	neutral	2.45	neutral	-2.53	deleterious	-5.41	high_impact	4.19	0.73	neutral	0.16	damaging	4.42	24.20	deleterious	0.14	0.4	0.35	neutral	0.89	disease	0.69	disease	0.73	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.18	medium_impact	2.47	high_impact	0.50	0.8	59.43	10.39	0.45	N	0.97	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3977	3977	T	A	MI.12152	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	671	224	F	Y	tTc/tAc	5.73	1	0	probably_damaging	1	neutral	1	neutral	2.58	neutral	-1.17	deleterious	-2.7	medium_impact	3.46	0.7	neutral	0.13	damaging	4.35	24.10	deleterious	0.18	0.45	0.27	neutral	0.82	disease	0.62	disease	0.68	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.74	deleterious	-3.57	low_impact	1.96	high_impact	1.83	medium_impact	0.61	0.8	59.43	10.39	0.51	N	0.88	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3977	3977	T	G	MI.12153	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	671	224	F	C	tTc/tGc	5.73	1	0	probably_damaging	1	neutral	0.17	neutral	2.38	deleterious	-4.91	deleterious	-7.23	high_impact	4.74	0.7	neutral	0.13	damaging	4.21	23.90	deleterious	0.03	0.35	0.66	disease	0.88	disease	0.71	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.11	medium_impact	2.95	high_impact	0.24	0.8	59.43	10.39	0.73	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3977	3977	T	C	MI.12154	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	671	224	F	S	tTc/tCc	5.73	1	0	probably_damaging	1	neutral	0.43	neutral	2.43	neutral	-2.96	deleterious	-7.17	high_impact	3.77	0.75	neutral	0.25	damaging	4.36	24.10	deleterious	0.02	0.35	0.23	neutral	0.87	disease	0.68	disease	0.72	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.21	medium_impact	2.1	high_impact	0.31	0.8	59.43	10.39	0.59	P	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3978	3978	C	A	MI.12155	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	672	224	F	L	ttC/ttA	5.73	1	0	probably_damaging	1	neutral	0.67	neutral	2.5	neutral	-1.86	deleterious	-5.41	high_impact	3.54	0.65	neutral	0.13	damaging	4.78	24.70	deleterious	0.11	0.4	0.25	neutral	0.85	disease	0.66	disease	0.72	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.45	medium_impact	1.9	medium_impact	0.60	0.8	59.43	10.39	0.53	N	0.92	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3978	3978	C	G	MI.12156	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	672	224	F	L	ttC/ttG	5.73	1	0	probably_damaging	1	neutral	0.67	neutral	2.5	neutral	-1.86	deleterious	-5.41	high_impact	3.54	0.65	neutral	0.13	damaging	4.42	24.20	deleterious	0.11	0.4	0.25	neutral	0.85	disease	0.66	disease	0.72	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.45	medium_impact	1.9	medium_impact	0.60	0.8	59.43	10.39	0.53	N	0.92	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3979	3979	A	G	MI.12157	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	673	225	M	V	Ata/Gta	-3	0	0	probably_damaging	0.99	neutral	0.51	neutral	2.93	neutral	1.26	neutral	-1.32	low_impact	1.57	0.61	neutral	0.21	damaging	2.72	20.90	deleterious	0.19	0.45	0.18	neutral	0.85	disease	0.51	disease	0.75	disease	5	0.99	deleterious	0.26	neutral	-2	neutral	0.72	deleterious	-2.62	low_impact	0.29	medium_impact	0.18	medium_impact	0.41	0.8	16.98	14.29	0.29	N	0.75	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3979	3979	A	T	MI.12158	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	673	225	M	L	Ata/Tta	-3	0	0	probably_damaging	0.98	neutral	0.77	neutral	3.27	neutral	2.83	neutral	1.19	neutral_impact	-1.39	0.8	neutral	0.95	neutral	0.60	8.14	deleterious	0.24	0.45	0.23	neutral	0.36	neutral	0.25	neutral	0.41	neutral	2	0.98	deleterious	0.4	neutral	-2	neutral	0.62	deleterious	-2.34	low_impact	0.57	medium_impact	-2.4	low_impact	0.39	0.8	16.98	14.29	0.26	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3979	3979	A	C	MI.12159	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	673	225	M	L	Ata/Cta	-3	0	0	probably_damaging	0.98	neutral	0.77	neutral	3.27	neutral	2.83	neutral	1.19	neutral_impact	-1.39	0.8	neutral	0.95	neutral	0.53	7.67	deleterious	0.24	0.45	0.23	neutral	0.36	neutral	0.25	neutral	0.41	neutral	2	0.98	deleterious	0.4	neutral	-2	neutral	0.62	deleterious	-2.34	low_impact	0.57	medium_impact	-2.4	low_impact	0.39	0.8	16.98	14.29	0.26	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9098	9098	T	A	MI.1216	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	572	191	I	N	aTc/aAc	-1.26	0	0	probably_damaging	1	deleterious	0.03	neutral	4.25	deleterious	-3.63	deleterious	-4.17	medium_impact	2.59	0.82	neutral	0.36	neutral	4.43	24.20	deleterious	0.21	0.65	0.84	disease	0.64	disease	0.59	disease	0.7	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.6	low_impact	-0.56	medium_impact	1.12	medium_impact	0.63	0.9	19.47	23.84	0.32	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3980	3980	T	A	MI.12160	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	674	225	M	K	aTa/aAa	-0.47	0	0	probably_damaging	1	neutral	0.29	neutral	2.74	neutral	-1.8	deleterious	-3.98	medium_impact	3.08	0.62	neutral	0.17	damaging	4.07	23.70	deleterious	0.01	0.35	0.6	disease	0.93	disease	0.69	disease	0.8	disease	6	1	deleterious	0.15	neutral	1	deleterious	0.86	deleterious	-3.57	low_impact	0.06	medium_impact	1.5	medium_impact	0.27	0.8	16.98	14.29	0.33	N	0.93	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3980	3980	T	C	MI.12161	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	674	225	M	T	aTa/aCa	-0.47	0	0	probably_damaging	1	neutral	0.39	neutral	2.77	neutral	-0.81	deleterious	-3.18	medium_impact	3.08	0.57	damaging	0.22	damaging	3.07	22.40	deleterious	0.07	0.35	0.4	neutral	0.81	disease	0.61	disease	0.76	disease	5	1	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.17	medium_impact	1.5	medium_impact	0.23	0.8	16.98	14.29	0.31	N	0.87	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3981	3981	A	T	MI.12162	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	675	225	M	I	atA/atT	7.34	0.99	0	probably_damaging	0.99	neutral	0.42	neutral	2.95	neutral	1.43	neutral	-0.53	neutral_impact	0.72	0.63	neutral	0.17	damaging	3.55	23.10	deleterious	0.25	0.45	0.16	neutral	0.85	disease	0.32	neutral	0.51	disease	0	0.99	deleterious	0.22	neutral	-2	neutral	0.74	deleterious	-2.62	low_impact	0.2	medium_impact	-0.56	medium_impact	0.50	0.8	16.98	14.29	0.5	P	0.74	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3981	3981	A	C	MI.12163	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	675	225	M	I	atA/atC	7.34	0.99	0	probably_damaging	0.99	neutral	0.42	neutral	2.95	neutral	1.43	neutral	-0.53	neutral_impact	0.72	0.63	neutral	0.17	damaging	3.43	23.00	deleterious	0.25	0.45	0.16	neutral	0.85	disease	0.32	neutral	0.51	disease	0	0.99	deleterious	0.22	neutral	-2	neutral	0.74	deleterious	-2.62	low_impact	0.2	medium_impact	-0.56	medium_impact	0.50	0.8	16.98	14.29	0.49	P	0.74	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3982	3982	G	T	MI.12164	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	676	226	A	S	Gcc/Tcc	-0.01	0.91	0	possibly_damaging	0.86	neutral	0.42	neutral	2.52	neutral	-1.66	deleterious	-2.68	medium_impact	1.96	0.7	neutral	0.12	damaging	3.78	23.40	deleterious	0.19	0.45	0.32	neutral	0.8	disease	0.3	neutral	0.46	neutral	1	0.85	neutral	0.28	neutral	0	NA	0.74	deleterious	-1.49	low_impact	0.2	medium_impact	0.52	medium_impact	0.47	0.8	59.75	10.37	0.3	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3982	3982	G	A	MI.12165	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	676	226	A	T	Gcc/Acc	-0.01	0.91	0	probably_damaging	0.95	neutral	0.31	neutral	2.46	neutral	-2.46	deleterious	-3.61	medium_impact	3.4	0.67	neutral	0.11	damaging	4.34	24.00	deleterious	0.11	0.4	0.43	neutral	0.89	disease	0.58	disease	0.7	disease	4	0.96	neutral	0.18	neutral	1	deleterious	0.82	deleterious	-1.95	low_impact	0.08	medium_impact	1.78	medium_impact	0.82	0.85	59.75	10.37	0.39	N	0.70	polymorphism	1	0.13	.	.	.	.	.	.	COSM1155625	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3982	3982	G	C	MI.12166	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	676	226	A	P	Gcc/Ccc	-0.01	0.91	0	probably_damaging	0.99	neutral	0.23	neutral	2.4	deleterious	-3.97	deleterious	-4.58	high_impact	3.81	0.77	neutral	0.12	damaging	3.90	23.50	deleterious	0.02	0.35	0.67	disease	0.91	disease	0.64	disease	0.72	disease	4	0.99	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-2.62	low_impact	-0.02	medium_impact	2.14	high_impact	0.46	0.8	59.75	10.37	0.36	N	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3983	3983	C	G	MI.12167	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	677	226	A	G	gCc/gGc	5.96	1	0	benign	0.15	neutral	0.42	neutral	2.66	neutral	-0.69	deleterious	-3.65	medium_impact	2.15	0.75	neutral	0.14	damaging	4.03	23.70	deleterious	0.18	0.45	0.27	neutral	0.8	disease	0.29	neutral	0.47	neutral	1	0.5	neutral	0.64	deleterious	-3	neutral	0.27	neutral	-0.04	medium_impact	0.2	medium_impact	0.69	medium_impact	0.71	0.85	59.75	10.37	0.57	P	0.79	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3983	3983	C	A	MI.12168	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	677	226	A	D	gCc/gAc	5.96	1	0	probably_damaging	0.98	neutral	0.16	neutral	2.41	deleterious	-3.75	deleterious	-5.46	high_impact	4.5	0.77	neutral	0.08	damaging	4.66	24.50	deleterious	0.01	0.35	0.6	disease	0.93	disease	0.7	disease	0.78	disease	6	0.99	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-2.34	low_impact	-0.13	medium_impact	2.74	high_impact	0.27	0.8	59.75	10.37	0.61	P	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3983	3983	C	T	MI.12169	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	677	226	A	V	gCc/gTc	5.96	1	0	probably_damaging	0.96	neutral	0.41	neutral	2.46	neutral	-2.5	deleterious	-3.67	high_impact	3.52	0.66	neutral	0.08	damaging	4.49	24.30	deleterious	0.06	0.35	0.33	neutral	0.9	disease	0.57	disease	0.7	disease	4	0.96	neutral	0.23	neutral	2	deleterious	0.78	deleterious	-2.05	low_impact	0.19	medium_impact	1.89	medium_impact	0.75	0.85	59.75	10.37	0.58	P	0.72	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9099	9099	C	A	MI.1217	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	573	191	I	M	atC/atA	4.76	0.72	0	probably_damaging	1	neutral	0.28	neutral	4.29	neutral	-2.21	neutral	-1.14	low_impact	1.09	0.92	neutral	0.69	neutral	2.72	20.90	deleterious	0.39	0.65	0.36	neutral	0.27	neutral	0.33	neutral	0.45	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.06	medium_impact	-0.16	medium_impact	0.78	0.9	19.47	23.84	0.47	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3985	3985	G	C	MI.12170	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	679	227	E	Q	Gaa/Caa	-1.85	0	0	probably_damaging	1	neutral	0.21	neutral	2.34	deleterious	-3.16	deleterious	-2.76	high_impact	4.25	0.69	neutral	0.13	damaging	3.45	23.00	deleterious	0.16	0.45	0.33	neutral	0.79	disease	0.68	disease	0.68	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.05	medium_impact	2.52	high_impact	0.67	0.85	59.12	10.38	0.43	N	0.91	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3985	3985	G	A	MI.12171	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	679	227	E	K	Gaa/Aaa	-1.85	0	0	probably_damaging	1	neutral	0.2	neutral	2.36	neutral	-2.72	deleterious	-3.68	high_impact	4.25	0.67	neutral	0.09	damaging	4.54	24.30	deleterious	0.07	0.35	0.32	neutral	0.92	disease	0.67	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.06	medium_impact	2.52	high_impact	0.62	0.8	59.12	10.38	0.48	N	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3986	3986	A	C	MI.12172	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	680	227	E	A	gAa/gCa	7.34	1	0	probably_damaging	1	neutral	0.67	neutral	2.35	neutral	-2.92	deleterious	-5.51	high_impact	4.8	0.71	neutral	0.16	damaging	3.77	23.40	deleterious	0.05	0.35	0.38	neutral	0.76	disease	0.67	disease	0.67	disease	3	1	deleterious	0.34	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.45	medium_impact	3	high_impact	0.32	0.8	59.12	10.38	0.68	P	0.74	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3986	3986	A	G	MI.12173	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	680	227	E	G	gAa/gGa	7.34	1	0	probably_damaging	1	neutral	0.3	neutral	2.32	deleterious	-3.64	deleterious	-6.43	high_impact	4.8	0.77	neutral	0.16	damaging	4.37	24.10	deleterious	0.05	0.35	0.55	disease	0.82	disease	0.66	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.07	medium_impact	3	high_impact	0.26	0.8	59.12	10.38	0.72	P	0.61	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3986	3986	A	T	MI.12174	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	680	227	E	V	gAa/gTa	7.34	1	0	probably_damaging	1	neutral	0.36	neutral	2.3	deleterious	-4.16	deleterious	-6.45	high_impact	4.8	0.64	neutral	0.11	damaging	4.34	24.00	deleterious	0.04	0.35	0.54	disease	0.9	disease	0.71	disease	0.75	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.14	medium_impact	3	high_impact	0.24	0.8	59.12	10.38	0.73	P	0.83	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3987	3987	A	C	MI.12175	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	681	227	E	D	gaA/gaC	6.88	1	0	probably_damaging	1	neutral	0.14	neutral	2.39	neutral	-2.37	deleterious	-2.76	high_impact	4.25	0.73	neutral	0.11	damaging	3.73	23.30	deleterious	0.19	0.45	0.43	neutral	0.76	disease	0.64	disease	0.67	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.17	medium_impact	2.52	high_impact	0.65	0.8	59.12	10.38	0.67	P	0.90	polymorphism	0.98	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3987	3987	A	T	MI.12176	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	681	227	E	D	gaA/gaT	6.88	1	0	probably_damaging	1	neutral	0.14	neutral	2.39	neutral	-2.37	deleterious	-2.76	high_impact	4.25	0.73	neutral	0.11	damaging	3.84	23.40	deleterious	0.19	0.45	0.43	neutral	0.76	disease	0.64	disease	0.67	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.17	medium_impact	2.52	high_impact	0.65	0.8	59.12	10.38	0.68	P	0.90	polymorphism	0.98	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3988	3988	T	C	MI.12177	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	682	228	Y	H	Tac/Cac	-0.93	0	0	probably_damaging	1	neutral	0.17	neutral	1.59	deleterious	-5.96	deleterious	-4.57	high_impact	4.79	0.59	damaging	0.03	damaging	3.71	23.30	deleterious	0.1	0.4	0.58	disease	0.83	disease	0.75	disease	0.76	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	-0.11	medium_impact	3	high_impact	0.13	0.8	59.12	10.6	0.66	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3988	3988	T	G	MI.12178	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	682	228	Y	D	Tac/Gac	-0.93	0	0	probably_damaging	1	neutral	0.06	neutral	1.58	deleterious	-6.73	deleterious	-9.15	high_impact	4.79	0.59	damaging	0.03	damaging	4.07	23.70	deleterious	0.04	0.35	0.37	neutral	0.87	disease	0.79	disease	0.77	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.4	medium_impact	3	high_impact	0.09	0.8	59.12	10.6	0.52	P	1.00	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3988	3988	T	A	MI.12179	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	682	228	Y	N	Tac/Aac	-0.93	0	0	probably_damaging	1	neutral	0.09	neutral	1.58	deleterious	-6.45	deleterious	-8.23	high_impact	3.98	0.57	damaging	0.04	damaging	4.31	24.00	deleterious	0.06	0.35	0.43	neutral	0.86	disease	0.72	disease	0.75	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	-0.29	medium_impact	2.29	high_impact	0.06	0.8	59.12	10.6	0.36	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9099	9099	C	G	MI.1218	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	573	191	I	M	atC/atG	4.76	0.72	0	probably_damaging	1	neutral	0.28	neutral	4.29	neutral	-2.21	neutral	-1.14	low_impact	1.09	0.92	neutral	0.69	neutral	2.19	17.45	deleterious	0.39	0.65	0.36	neutral	0.27	neutral	0.33	neutral	0.45	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.06	medium_impact	-0.16	medium_impact	0.78	0.9	19.47	23.84	0.46	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3989	3989	A	C	MI.12180	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	683	228	Y	S	tAc/tCc	5.73	1	0	probably_damaging	1	neutral	0.34	neutral	1.59	deleterious	-6.02	deleterious	-8.22	high_impact	4.24	0.51	damaging	0.06	damaging	3.74	23.30	deleterious	0.06	0.35	0.31	neutral	0.85	disease	0.71	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.11	medium_impact	2.51	high_impact	0.14	0.8	59.12	10.6	0.52	N	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3989	3989	A	T	MI.12181	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	683	228	Y	F	tAc/tTc	5.73	1	0	probably_damaging	1	neutral	1	neutral	1.7	deleterious	-3.78	deleterious	-3.66	high_impact	3.69	0.59	damaging	0.03	damaging	3.37	22.90	deleterious	0.13	0.4	0.59	disease	0.84	disease	0.64	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.82	deleterious	-3.57	low_impact	1.96	high_impact	2.03	high_impact	0.31	0.8	59.12	10.6	0.52	P	0.80	polymorphism	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3989	3989	A	G	MI.12182	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	683	228	Y	C	tAc/tGc	5.73	1	0	probably_damaging	1	neutral	0.05	neutral	1.57	deleterious	-7.85	deleterious	-8.25	high_impact	4.79	0.55	damaging	0.03	damaging	3.51	23.10	deleterious	0.04	0.35	0.75	disease	0.88	disease	0.76	disease	0.77	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.44	medium_impact	3	high_impact	0.03	0.8	59.12	10.6	0.59	P	1.00	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3991	3991	A	T	MI.12183	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	685	229	T	S	Aca/Tca	-5.3	0	0	benign	0.19	neutral	0.36	neutral	2.82	neutral	0.23	neutral	0.78	neutral_impact	-0.02	0.78	neutral	0.7	neutral	0.09	3.49	deleterious	0.33	0.5	0.2	neutral	0.26	neutral	0.16	neutral	0.42	neutral	2	0.57	neutral	0.59	deleterious	-6	neutral	0.18	neutral	-0.16	medium_impact	0.14	medium_impact	-1.21	low_impact	0.71	0.85	27.04	41.49	0.47	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3991	3991	A	G	MI.12184	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	685	229	T	A	Aca/Gca	-5.3	0	0	benign	0.1	neutral	0.72	neutral	2.95	neutral	1.79	neutral	1.54	neutral_impact	-1.36	0.74	neutral	0.95	neutral	-1.19	0.01	neutral	0.25	0.45	0.16	neutral	0.08	neutral	0.14	neutral	0.28	neutral	4	0.17	neutral	0.81	deleterious	-6	neutral	0.12	neutral	0.15	medium_impact	0.51	medium_impact	-2.38	low_impact	0.29	0.8	27.04	41.49	0.44	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3991	3991	A	C	MI.12185	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	685	229	T	P	Aca/Cca	-5.3	0	0	possibly_damaging	0.65	neutral	0.13	neutral	2.74	neutral	-2.17	neutral	-1.67	medium_impact	2.35	0.63	neutral	0.39	neutral	1.69	14.35	neutral	0.06	0.35	0.44	neutral	0.88	disease	0.62	disease	0.8	disease	6	0.88	neutral	0.24	neutral	0	NA	0.62	deleterious	-1	low_impact	-0.19	medium_impact	0.86	medium_impact	0.38	0.8	27.04	41.49	0.34	N	0.62	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3992	3992	C	A	MI.12186	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	686	229	T	K	aCa/aAa	2.75	0.11	0.03	benign	0.29	neutral	0.18	neutral	2.78	neutral	-1.19	neutral	-1.37	medium_impact	2.69	0.64	neutral	0.48	neutral	2.62	20.30	deleterious	0.08	0.35	0.3	neutral	0.84	disease	0.58	disease	0.78	disease	6	0.79	neutral	0.45	neutral	-3	neutral	0.30	neutral	-0.39	medium_impact	-0.09	medium_impact	1.16	medium_impact	0.45	0.8	27.04	41.49	0.46	N	0.52	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3992	3992	C	T	MI.12187	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	686	229	T	M	aCa/aTa	2.75	0.11	0.03	benign	0.01	neutral	0.27	neutral	2.76	neutral	0.19	neutral	-1.15	neutral_impact	0.4	0.78	neutral	0.94	neutral	0.92	10.18	neutral	0.14	0.4	0.23	neutral	0.58	disease	0.21	neutral	0.42	neutral	2	0.72	neutral	0.63	deleterious	-6	neutral	0.14	neutral	1.12	medium_impact	0.03	medium_impact	-0.84	medium_impact	0.58	0.8	27.04	41.49	0.38	N	0.04	polymorphism	1	0.03	rs879051705	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	3994	3994	A	G	MI.12188	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	688	230	N	D	Aac/Gac	-8.97	0	0	possibly_damaging	0.86	neutral	0.18	neutral	2.53	neutral	-2.36	deleterious	-4.57	high_impact	3.89	0.64	neutral	0.48	neutral	3.96	23.60	deleterious	0.5	0.6	0.33	neutral	0.84	disease	0.7	disease	0.75	disease	5	0.92	neutral	0.16	neutral	1	deleterious	0.70	deleterious	-1.49	low_impact	-0.09	medium_impact	2.21	high_impact	0.26	0.8	60.06	10.24	0.54	N	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3994	3994	A	C	MI.12189	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	688	230	N	H	Aac/Cac	-8.97	0	0	probably_damaging	0.99	neutral	0.48	neutral	2.48	deleterious	-3.86	deleterious	-4.57	medium_impact	2.96	0.68	neutral	0.39	neutral	3.15	22.60	deleterious	0.28	0.45	0.31	neutral	0.83	disease	0.65	disease	0.54	disease	1	0.99	deleterious	0.25	neutral	1	deleterious	0.74	deleterious	-2.62	low_impact	0.26	medium_impact	1.4	medium_impact	0.16	0.8	60.06	10.24	0.33	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9100	9100	A	G	MI.1219	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	574	192	I	V	Atc/Gtc	-10.98	0	0	benign	0.08	neutral	0.57	neutral	4.36	neutral	-0.45	neutral	0.54	neutral_impact	0.76	0.96	neutral	0.75	neutral	1.30	12.26	neutral	0.59	0.7	0.35	neutral	0.22	neutral	0.31	neutral	0.39	neutral	2	0.35	neutral	0.75	deleterious	-6	neutral	0.15	neutral	0.25	medium_impact	0.36	medium_impact	-0.45	medium_impact	0.57	0.9	12.83	11.48	0.32	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3994	3994	A	T	MI.12190	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	688	230	N	Y	Aac/Tac	-8.97	0	0	probably_damaging	0.99	neutral	1	neutral	2.47	deleterious	-4.48	deleterious	-7.31	medium_impact	3.05	0.67	neutral	0.36	neutral	3.81	23.40	deleterious	0.06	0.35	0.51	disease	0.91	disease	0.67	disease	0.74	disease	5	0.99	deleterious	0.51	deleterious	1	deleterious	0.80	deleterious	-2.62	low_impact	1.96	high_impact	1.48	medium_impact	0.14	0.8	60.06	10.24	0.24	N	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3995	3995	A	T	MI.12191	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	689	230	N	I	aAc/aTc	8.49	1	0	probably_damaging	0.98	neutral	0.46	neutral	2.48	deleterious	-3.76	deleterious	-8.22	medium_impact	2.92	0.69	neutral	0.56	neutral	3.90	23.50	deleterious	0.08	0.35	0.54	disease	0.94	disease	0.62	disease	0.78	disease	6	0.98	neutral	0.24	neutral	1	deleterious	0.80	deleterious	-2.34	low_impact	0.24	medium_impact	1.36	medium_impact	0.11	0.8	60.06	10.24	0.54	P	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3995	3995	A	C	MI.12192	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	689	230	N	T	aAc/aCc	8.49	1	0	possibly_damaging	0.81	neutral	0.38	neutral	2.53	neutral	-2.28	deleterious	-5.47	high_impact	3.63	0.61	neutral	0.46	neutral	3.43	23.00	deleterious	0.27	0.45	0.33	neutral	0.87	disease	0.63	disease	0.71	disease	4	0.82	neutral	0.29	neutral	1	deleterious	0.70	deleterious	-1.34	low_impact	0.16	medium_impact	1.98	medium_impact	0.17	0.8	60.06	10.24	0.64	P	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3995	3995	A	G	MI.12193	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	689	230	N	S	aAc/aGc	8.49	1	0	benign	0.26	neutral	0.41	neutral	2.64	neutral	-1.02	deleterious	-4.55	medium_impact	2.15	0.75	neutral	0.6	neutral	3.09	22.50	deleterious	0.53	0.6	0.19	neutral	0.59	disease	0.4	neutral	0.41	neutral	2	0.5	neutral	0.58	deleterious	-3	neutral	0.34	neutral	-0.32	medium_impact	0.19	medium_impact	0.69	medium_impact	0.10	0.8	60.06	10.24	0.66	P	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	CPD	0.15	A3995G	MELAS	.	.	Reported	1	.	P	P	neutral
chrM	3996	3996	C	A	MI.12194	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	690	230	N	K	aaC/aaA	8.49	1	0	possibly_damaging	0.88	neutral	0.26	neutral	2.54	neutral	-2.19	deleterious	-5.48	high_impact	3.54	0.63	neutral	0.35	neutral	4.57	24.40	deleterious	0.44	0.55	0.16	neutral	0.91	disease	0.7	disease	0.75	disease	5	0.91	neutral	0.19	neutral	1	deleterious	0.71	deleterious	-1.56	low_impact	0.02	medium_impact	1.9	medium_impact	0.31	0.8	60.06	10.24	0.62	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3996	3996	C	G	MI.12195	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	690	230	N	K	aaC/aaG	8.49	1	0	possibly_damaging	0.88	neutral	0.26	neutral	2.54	neutral	-2.19	deleterious	-5.48	high_impact	3.54	0.63	neutral	0.35	neutral	4.07	23.70	deleterious	0.44	0.55	0.16	neutral	0.91	disease	0.7	disease	0.75	disease	5	0.91	neutral	0.19	neutral	1	deleterious	0.71	deleterious	-1.56	low_impact	0.02	medium_impact	1.9	medium_impact	0.31	0.8	60.06	10.24	0.61	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3997	3997	A	T	MI.12196	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	691	231	I	F	Att/Ttt	-2.77	0	0	probably_damaging	1	neutral	0.99	neutral	2.46	deleterious	-3	deleterious	-3.63	high_impact	3.62	0.68	neutral	0.15	damaging	3.60	23.20	deleterious	0.16	0.45	0.38	neutral	0.79	disease	0.67	disease	0.68	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.76	deleterious	-3.57	low_impact	1.39	medium_impact	1.97	medium_impact	0.64	0.8	59.43	10.6	0.29	N	0.95	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3997	3997	A	C	MI.12197	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	691	231	I	L	Att/Ctt	-2.77	0	0	probably_damaging	1	neutral	1	neutral	2.89	neutral	0.3	neutral	-1.8	medium_impact	2.58	0.71	neutral	0.13	damaging	3.59	23.20	deleterious	0.28	0.45	0.15	neutral	0.68	disease	0.6	disease	0.66	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.68	deleterious	-3.57	low_impact	1.96	high_impact	1.07	medium_impact	0.66	0.8	59.43	10.6	0.24	N	0.82	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3997	3997	A	G	MI.12198	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	691	231	I	V	Att/Gtt	-2.77	0	0	probably_damaging	1	neutral	0.31	neutral	2.61	neutral	-1.06	neutral	-0.9	medium_impact	2.81	0.77	neutral	0.19	damaging	2.90	21.90	deleterious	0.5	0.6	0.2	neutral	0.46	neutral	0.59	disease	0.46	neutral	1	1	deleterious	0.16	neutral	1	deleterious	0.68	deleterious	-3.57	low_impact	0.08	medium_impact	1.27	medium_impact	0.58	0.8	59.43	10.6	0.34	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3998	3998	T	A	MI.12199	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	692	231	I	N	aTt/aAt	8.49	1	0	probably_damaging	1	neutral	0.25	neutral	2.42	deleterious	-5.15	deleterious	-6.37	high_impact	3.98	0.73	neutral	0.15	damaging	4.48	24.20	deleterious	0.13	0.4	0.6	disease	0.82	disease	0.64	disease	0.68	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.01	medium_impact	2.29	high_impact	0.33	0.8	59.43	10.6	0.61	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8582	8582	C	A	MI.122	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	56	19	A	D	gCc/gAc	-0.57	0	0	probably_damaging	1	deleterious	0	neutral	4.58	neutral	-2.54	deleterious	-3.05	low_impact	0.8	0.77	neutral	0.45	neutral	4.30	24.00	deleterious	0.13	0.65	0.83	disease	0.77	disease	0.61	disease	0.77	disease	5	1	deleterious	0	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	-0.41	medium_impact	0.46	0.9	29.65	29.28	0.24	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9100	9100	A	T	MI.1220	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	574	192	I	F	Atc/Ttc	-10.98	0	0	possibly_damaging	0.6	neutral	0.55	neutral	4.33	neutral	-0.99	neutral	-1.19	low_impact	0.94	0.91	neutral	0.76	neutral	3.47	23.00	deleterious	0.42	0.65	0.54	disease	0.59	disease	0.33	neutral	0.48	neutral	0	0.55	neutral	0.48	deleterious	-3	neutral	0.56	deleterious	-0.92	medium_impact	0.34	medium_impact	-0.29	medium_impact	0.72	0.9	12.83	11.48	0.27	N	0.28	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	3998	3998	T	C	MI.12200	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	692	231	I	T	aTt/aCt	8.49	1	0	probably_damaging	1	neutral	0.22	neutral	2.45	deleterious	-3.43	deleterious	-4.53	high_impact	3.98	0.66	neutral	0.14	damaging	3.44	23.00	deleterious	0.07	0.35	0.29	neutral	0.76	disease	0.58	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	-0.03	medium_impact	2.29	high_impact	0.40	0.8	59.43	10.6	0.62	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3998	3998	T	G	MI.12201	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	692	231	I	S	aTt/aGt	8.49	1	0	probably_damaging	1	neutral	0.31	neutral	2.43	deleterious	-4.1	deleterious	-5.44	high_impact	4.17	0.72	neutral	0.19	damaging	4.33	24.00	deleterious	0.03	0.35	0.43	neutral	0.83	disease	0.65	disease	0.69	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.08	medium_impact	2.45	high_impact	0.29	0.8	59.43	10.6	0.63	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3999	3999	T	A	MI.12202	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	693	231	I	M	atT/atA	7.34	1	0	probably_damaging	1	neutral	0.42	neutral	2.56	neutral	-1.54	deleterious	-2.68	medium_impact	2.09	0.73	neutral	0.15	damaging	3.77	23.40	deleterious	0.38	0.5	0.24	neutral	0.63	disease	0.55	disease	0.42	neutral	2	1	deleterious	0.21	neutral	1	deleterious	0.68	deleterious	-3.57	low_impact	0.2	medium_impact	0.64	medium_impact	0.65	0.8	59.43	10.6	0.56	P	0.74	polymorphism	0.98	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	3999	3999	T	G	MI.12203	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	693	231	I	M	atT/atG	7.34	1	0	probably_damaging	1	neutral	0.42	neutral	2.56	neutral	-1.54	deleterious	-2.68	medium_impact	2.09	0.73	neutral	0.15	damaging	3.45	23.00	deleterious	0.38	0.5	0.24	neutral	0.63	disease	0.55	disease	0.42	neutral	2	1	deleterious	0.21	neutral	1	deleterious	0.68	deleterious	-3.57	low_impact	0.2	medium_impact	0.64	medium_impact	0.65	0.8	59.43	10.6	0.56	P	0.74	polymorphism	0.98	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4000	4000	A	G	MI.12204	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	694	232	I	V	Att/Gtt	-2.54	0	0	possibly_damaging	0.53	neutral	0.5	neutral	2.77	neutral	0.13	neutral	-0.77	low_impact	1.88	0.71	neutral	0.09	damaging	3.11	22.50	deleterious	0.43	0.55	0.17	neutral	0.4	neutral	0.56	disease	0.48	neutral	0	0.52	neutral	0.49	deleterious	-3	neutral	0.33	neutral	-0.8	medium_impact	0.28	medium_impact	0.45	medium_impact	0.51	0.8	24.84	12.94	0.28	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4000	4000	A	C	MI.12205	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	694	232	I	L	Att/Ctt	-2.54	0	0	benign	0.26	neutral	0.65	neutral	2.85	neutral	-0.6	neutral	0.81	neutral_impact	0	0.84	neutral	0.6	neutral	1.10	11.24	neutral	0.27	0.45	0.14	neutral	0.16	neutral	0.26	neutral	0.23	neutral	5	0.25	neutral	0.7	deleterious	-6	neutral	0.20	neutral	-0.32	medium_impact	0.43	medium_impact	-1.19	low_impact	0.57	0.8	24.84	12.94	0.26	N	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4000	4000	A	T	MI.12206	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	694	232	I	F	Att/Ttt	-2.54	0	0	possibly_damaging	0.89	neutral	0.7	neutral	2.64	neutral	-0.57	neutral	-2.09	low_impact	1.83	0.68	neutral	0.08	damaging	3.82	23.40	deleterious	0.2	0.45	0.27	neutral	0.74	disease	0.59	disease	0.7	disease	4	0.87	neutral	0.41	neutral	-3	neutral	0.66	deleterious	-1.6	low_impact	0.48	medium_impact	0.41	medium_impact	0.58	0.8	24.84	12.94	0.21	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4001	4001	T	A	MI.12207	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	695	232	I	N	aTt/aAt	0.91	0.42	0	probably_damaging	0.97	neutral	0.31	neutral	2.61	deleterious	-4.05	deleterious	-4.67	high_impact	3.8	0.68	neutral	0.1	damaging	4.39	24.10	deleterious	0.07	0.35	0.67	disease	0.79	disease	0.59	disease	0.72	disease	4	0.97	neutral	0.17	neutral	2	deleterious	0.79	deleterious	-2.17	low_impact	0.08	medium_impact	2.13	high_impact	0.28	0.8	24.84	12.94	0.35	N	0.99	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4001	4001	T	G	MI.12208	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	695	232	I	S	aTt/aGt	0.91	0.42	0	probably_damaging	0.91	neutral	0.4	neutral	2.65	neutral	-2.64	deleterious	-3.74	high_impact	3.8	0.7	neutral	0.09	damaging	4.30	24.00	deleterious	0.03	0.35	0.49	neutral	0.77	disease	0.59	disease	0.71	disease	4	0.91	neutral	0.25	neutral	2	deleterious	0.72	deleterious	-1.69	low_impact	0.18	medium_impact	2.13	high_impact	0.26	0.8	24.84	12.94	0.3	N	0.94	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4001	4001	T	C	MI.12209	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	695	232	I	T	aTt/aCt	0.91	0.42	0	possibly_damaging	0.88	neutral	0.39	neutral	2.68	neutral	-1.84	deleterious	-2.97	medium_impact	2.9	0.7	neutral	0.08	damaging	3.39	23.00	deleterious	0.08	0.35	0.42	neutral	0.62	disease	0.58	disease	0.69	disease	4	0.88	neutral	0.26	neutral	0	NA	0.64	deleterious	-1.56	low_impact	0.17	medium_impact	1.34	medium_impact	0.25	0.8	24.84	12.94	0.29	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9100	9100	A	C	MI.1221	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	574	192	I	L	Atc/Ctc	-10.98	0	0	benign	0.08	neutral	0.82	neutral	4.38	neutral	-0.16	neutral	-0.03	neutral_impact	0.22	0.87	neutral	0.77	neutral	2.04	16.50	deleterious	0.4	0.65	0.22	neutral	0.31	neutral	0.26	neutral	0.44	neutral	1	0.08	neutral	0.87	deleterious	-6	neutral	0.15	neutral	0.25	medium_impact	0.66	medium_impact	-0.91	medium_impact	0.61	0.9	12.83	11.48	0.33	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4002	4002	T	A	MI.12210	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	696	232	I	M	atT/atA	7.34	0.98	0	possibly_damaging	0.52	neutral	0.22	neutral	2.66	neutral	-2.46	neutral	-0.15	low_impact	1	0.84	neutral	0.85	neutral	2.29	18.08	deleterious	0.22	0.45	0.38	neutral	0.36	neutral	0.36	neutral	0.46	neutral	1	0.76	neutral	0.35	neutral	-3	neutral	0.27	neutral	-0.78	medium_impact	-0.03	medium_impact	-0.32	medium_impact	0.62	0.8	24.84	12.94	0.65	P	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4002	4002	T	G	MI.12211	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	696	232	I	M	atT/atG	7.34	0.98	0	possibly_damaging	0.52	neutral	0.22	neutral	2.66	neutral	-2.46	neutral	-0.15	low_impact	1	0.84	neutral	0.85	neutral	1.96	15.98	deleterious	0.22	0.45	0.38	neutral	0.36	neutral	0.36	neutral	0.46	neutral	1	0.76	neutral	0.35	neutral	-3	neutral	0.27	neutral	-0.78	medium_impact	-0.03	medium_impact	-0.32	medium_impact	0.62	0.8	24.84	12.94	0.66	P	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4003	4003	A	T	MI.12212	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	697	233	M	L	Ata/Tta	-8.51	0	0	benign	0.02	neutral	0.65	neutral	3.12	neutral	2.19	neutral	-0.5	neutral_impact	-0.1	0.88	neutral	0.91	neutral	-1.05	0.01	neutral	0.28	0.45	0.17	neutral	0.29	neutral	0.38	neutral	0.43	neutral	1	0.32	neutral	0.82	deleterious	-6	neutral	0.12	neutral	0.84	medium_impact	0.43	medium_impact	-1.28	low_impact	0.47	0.8	25.79	30.42	0.34	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4003	4003	A	G	MI.12213	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	697	233	M	V	Ata/Gta	-8.51	0	0	benign	0.4	neutral	0.49	neutral	2.94	neutral	1.27	neutral	-2.04	low_impact	1.59	0.88	neutral	0.54	neutral	0.97	10.52	neutral	0.23	0.45	0.15	neutral	0.66	disease	0.5	neutral	0.45	neutral	1	0.45	neutral	0.55	deleterious	-6	neutral	0.29	neutral	-0.59	medium_impact	0.27	medium_impact	0.2	medium_impact	0.53	0.8	25.79	30.42	0.29	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4003	4003	A	C	MI.12214	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	697	233	M	L	Ata/Cta	-8.51	0	0	benign	0.02	neutral	0.65	neutral	3.12	neutral	2.19	neutral	-0.5	neutral_impact	-0.1	0.88	neutral	0.91	neutral	-1.12	0.01	neutral	0.28	0.45	0.17	neutral	0.29	neutral	0.38	neutral	0.43	neutral	1	0.32	neutral	0.82	deleterious	-6	neutral	0.12	neutral	0.84	medium_impact	0.43	medium_impact	-1.28	low_impact	0.47	0.8	25.79	30.42	0.34	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4004	4004	T	A	MI.12215	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	698	233	M	K	aTa/aAa	-0.24	0	0	possibly_damaging	0.84	neutral	0.29	neutral	2.74	neutral	-1.77	deleterious	-4.27	medium_impact	3.44	0.6	damaging	0.09	damaging	2.09	16.81	deleterious	0.04	0.35	0.39	neutral	0.86	disease	0.7	disease	0.77	disease	5	0.87	neutral	0.23	neutral	0	NA	0.66	deleterious	-1.43	low_impact	0.06	medium_impact	1.82	medium_impact	0.29	0.8	25.79	30.42	0.34	N	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4004	4004	T	C	MI.12216	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	698	233	M	T	aTa/aCa	-0.24	0	0	possibly_damaging	0.68	neutral	0.39	neutral	2.79	neutral	-0.29	deleterious	-3.59	low_impact	1.6	0.79	neutral	0.15	damaging	1.09	11.18	neutral	0.09	0.4	0.18	neutral	0.7	disease	0.5	neutral	0.5	neutral	0	0.71	neutral	0.36	neutral	-3	neutral	0.48	deleterious	-1.06	low_impact	0.17	medium_impact	0.21	medium_impact	0.22	0.8	25.79	30.42	0.23	N	0.66	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4005	4005	A	C	MI.12217	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	699	233	M	I	atA/atC	4.58	0.65	0	benign	0.29	neutral	0.4	neutral	2.86	neutral	0.61	neutral	-1.68	low_impact	1.55	0.87	neutral	0.27	damaging	1.60	13.87	neutral	0.3	0.45	0.14	neutral	0.72	disease	0.47	neutral	0.5	neutral	0	0.52	neutral	0.56	deleterious	-6	neutral	0.29	neutral	-0.39	medium_impact	0.18	medium_impact	0.17	medium_impact	0.53	0.8	25.79	30.42	0.33	N	0.37	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4005	4005	A	T	MI.12218	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	699	233	M	I	atA/atT	4.58	0.65	0	benign	0.29	neutral	0.4	neutral	2.86	neutral	0.61	neutral	-1.68	low_impact	1.55	0.87	neutral	0.27	damaging	1.67	14.24	neutral	0.3	0.45	0.14	neutral	0.72	disease	0.47	neutral	0.5	neutral	0	0.52	neutral	0.56	deleterious	-6	neutral	0.29	neutral	-0.39	medium_impact	0.18	medium_impact	0.17	medium_impact	0.53	0.8	25.79	30.42	0.34	N	0.37	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4006	4006	A	T	MI.12219	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	700	234	M	L	Ata/Tta	-1.62	0	0	probably_damaging	0.98	neutral	0.71	neutral	2.73	neutral	0.57	deleterious	-2.75	medium_impact	2.44	0.57	damaging	0.03	damaging	3.33	22.90	deleterious	0.26	0.45	0.18	neutral	0.77	disease	0.63	disease	0.62	disease	2	0.98	deleterious	0.37	neutral	1	deleterious	0.73	deleterious	-2.34	low_impact	0.49	medium_impact	0.94	medium_impact	0.37	0.8	58.49	10.65	0.23	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9101	9101	T	G	MI.1222	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	575	192	I	S	aTc/aGc	4.76	0.99	0.01	benign	0.16	neutral	0.34	neutral	4.36	neutral	-0.41	neutral	0.8	neutral_impact	0.66	0.91	neutral	0.89	neutral	2.50	19.47	deleterious	0.34	0.65	0.5	disease	0.56	disease	0.33	neutral	0.46	neutral	1	0.6	neutral	0.59	deleterious	-6	neutral	0.29	neutral	-0.07	medium_impact	0.13	medium_impact	-0.53	medium_impact	0.66	0.9	12.83	11.48	0.52	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4006	4006	A	C	MI.12220	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	700	234	M	L	Ata/Cta	-1.62	0	0	probably_damaging	0.98	neutral	0.71	neutral	2.73	neutral	0.57	deleterious	-2.75	medium_impact	2.44	0.57	damaging	0.03	damaging	3.26	22.80	deleterious	0.26	0.45	0.18	neutral	0.77	disease	0.63	disease	0.62	disease	2	0.98	deleterious	0.37	neutral	1	deleterious	0.73	deleterious	-2.34	low_impact	0.49	medium_impact	0.94	medium_impact	0.37	0.8	58.49	10.65	0.23	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4006	4006	A	G	MI.12221	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	700	234	M	V	Ata/Gta	-1.62	0	0	probably_damaging	0.99	neutral	0.45	neutral	2.7	neutral	0.97	deleterious	-3.66	medium_impact	2.53	0.54	damaging	0.06	damaging	2.74	21.00	deleterious	0.29	0.45	0.2	neutral	0.75	disease	0.69	disease	0.62	disease	2	0.99	deleterious	0.23	neutral	1	deleterious	0.75	deleterious	-2.62	low_impact	0.23	medium_impact	1.02	medium_impact	0.42	0.8	58.49	10.65	0.25	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4007	4007	T	A	MI.12222	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	701	234	M	K	aTa/aAa	8.49	1	0	probably_damaging	1	neutral	0.24	neutral	2.61	neutral	-2.66	deleterious	-5.53	high_impact	4.46	0.56	damaging	0.04	damaging	4.14	23.80	deleterious	0.04	0.35	0.47	neutral	0.88	disease	0.76	disease	0.75	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.01	medium_impact	2.71	high_impact	0.20	0.8	58.49	10.65	0.67	P	1.00	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4007	4007	T	C	MI.12223	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	701	234	M	T	aTa/aCa	8.49	1	0	probably_damaging	1	neutral	0.34	neutral	2.63	neutral	-1.34	deleterious	-5.51	high_impact	4.12	0.49	damaging	0.08	damaging	3.08	22.50	deleterious	0.08	0.35	0.29	neutral	0.83	disease	0.67	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.11	medium_impact	2.41	high_impact	0.12	0.8	58.49	10.65	0.61	P	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4008	4008	A	C	MI.12224	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	702	234	M	I	atA/atC	4.58	1	0	probably_damaging	0.99	neutral	0.51	neutral	2.7	neutral	0.27	deleterious	-3.65	medium_impact	2.5	0.57	damaging	0.05	damaging	3.24	22.80	deleterious	0.27	0.45	0.28	neutral	0.78	disease	0.64	disease	0.5	neutral	0	0.99	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-2.62	low_impact	0.29	medium_impact	1	medium_impact	0.33	0.8	58.49	10.65	0.45	N	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4008	4008	A	T	MI.12225	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	702	234	M	I	atA/atT	4.58	1	0	probably_damaging	0.99	neutral	0.51	neutral	2.7	neutral	0.27	deleterious	-3.65	medium_impact	2.5	0.57	damaging	0.05	damaging	3.32	22.90	deleterious	0.27	0.45	0.28	neutral	0.78	disease	0.64	disease	0.5	neutral	0	0.99	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-2.62	low_impact	0.29	medium_impact	1	medium_impact	0.33	0.8	58.49	10.65	0.46	N	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4009	4009	A	C	MI.12226	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	703	235	N	H	Aac/Cac	4.58	1	0	probably_damaging	1	neutral	0.54	neutral	2.66	neutral	-2.79	deleterious	-4.61	high_impact	3.88	0.68	neutral	0.08	damaging	3.17	22.70	deleterious	0.29	0.45	0.42	neutral	0.84	disease	0.67	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.31	medium_impact	2.2	high_impact	0.38	0.8	59.12	10.45	0.5	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4009	4009	A	G	MI.12227	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	703	235	N	D	Aac/Gac	4.58	1	0	probably_damaging	1	neutral	0.2	neutral	2.69	neutral	-1.87	deleterious	-4.6	high_impact	3.88	0.71	neutral	0.11	damaging	3.93	23.50	deleterious	0.36	0.5	0.33	neutral	0.82	disease	0.66	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	-0.06	medium_impact	2.2	high_impact	0.44	0.8	59.12	10.45	0.6	P	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4009	4009	A	T	MI.12228	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	703	235	N	Y	Aac/Tac	4.58	1	0	probably_damaging	1	neutral	1	neutral	2.66	deleterious	-3.08	deleterious	-7.37	high_impact	3.54	0.71	neutral	0.08	damaging	3.77	23.40	deleterious	0.1	0.4	0.4	neutral	0.9	disease	0.62	disease	0.71	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.57	low_impact	1.96	high_impact	1.9	medium_impact	0.32	0.8	59.12	10.45	0.4	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4010	4010	A	T	MI.12229	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	704	235	N	I	aAc/aTc	8.49	1	0	probably_damaging	1	neutral	0.39	neutral	2.68	neutral	-2.08	deleterious	-8.3	high_impact	3.88	0.73	neutral	0.11	damaging	3.91	23.50	deleterious	0.13	0.4	0.2	neutral	0.92	disease	0.56	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.17	medium_impact	2.2	high_impact	0.24	0.8	59.12	10.45	0.56	P	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9101	9101	T	A	MI.1223	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	575	192	I	N	aTc/aAc	4.76	0.99	0.01	possibly_damaging	0.44	neutral	0.25	neutral	4.29	neutral	-2.02	neutral	-0.32	low_impact	1.38	0.87	neutral	0.49	neutral	2.86	21.70	deleterious	0.28	0.65	0.66	disease	0.65	disease	0.54	disease	0.69	disease	4	0.71	neutral	0.41	neutral	-3	neutral	0.56	deleterious	-0.66	medium_impact	0.02	medium_impact	0.09	medium_impact	0.69	0.9	12.83	11.48	0.52	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4010	4010	A	C	MI.12230	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	704	235	N	T	aAc/aCc	8.49	1	0	probably_damaging	1	neutral	0.39	neutral	2.73	neutral	-0.96	deleterious	-5.52	medium_impact	3.34	0.64	neutral	0.1	damaging	3.46	23.00	deleterious	0.25	0.45	0.19	neutral	0.85	disease	0.57	disease	0.69	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.17	medium_impact	1.73	medium_impact	0.46	0.8	59.12	10.45	0.51	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4010	4010	A	G	MI.12231	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	704	235	N	S	aAc/aGc	8.49	1	0	probably_damaging	1	neutral	0.4	neutral	3	neutral	1.19	deleterious	-4.59	low_impact	1.03	0.65	neutral	0.11	damaging	3.07	22.40	deleterious	0.41	0.5	0.16	neutral	0.39	neutral	0.39	neutral	0.37	neutral	3	1	deleterious	0.2	neutral	-2	neutral	0.67	deleterious	-3.57	low_impact	0.18	medium_impact	-0.29	medium_impact	0.43	0.8	59.12	10.45	0.53	P	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4011	4011	C	G	MI.12232	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	705	235	N	K	aaC/aaG	8.49	1	0	probably_damaging	1	neutral	0.29	neutral	2.72	neutral	-1.15	deleterious	-5.53	high_impact	3.88	0.75	neutral	0.11	damaging	4.04	23.70	deleterious	0.26	0.45	0.23	neutral	0.9	disease	0.66	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.06	medium_impact	2.2	high_impact	0.48	0.8	59.12	10.45	0.62	P	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4011	4011	C	A	MI.12233	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	705	235	N	K	aaC/aaA	8.49	1	0	probably_damaging	1	neutral	0.29	neutral	2.72	neutral	-1.15	deleterious	-5.53	high_impact	3.88	0.75	neutral	0.11	damaging	4.46	24.20	deleterious	0.26	0.45	0.23	neutral	0.9	disease	0.66	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	0.06	medium_impact	2.2	high_impact	0.48	0.8	59.12	10.45	0.62	P	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4012	4012	A	C	MI.12234	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	706	236	T	P	Acc/Ccc	-0.7	0	0	benign	0.41	neutral	0.16	neutral	2.7	neutral	-2.6	deleterious	-4.43	high_impact	3.54	0.67	neutral	0.45	neutral	1.66	14.20	neutral	0.06	0.35	0.47	neutral	0.83	disease	0.61	disease	0.71	disease	4	0.81	neutral	0.38	neutral	-2	neutral	0.42	neutral	-0.6	medium_impact	-0.13	medium_impact	1.9	medium_impact	0.49	0.8	16.98	36.64	0.4	N	0.27	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4012	4012	A	T	MI.12235	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	706	236	T	S	Acc/Tcc	-0.7	0	0	benign	0.12	neutral	0.69	neutral	2.76	neutral	0.39	deleterious	-2.61	low_impact	0.98	0.79	neutral	0.76	neutral	1.30	12.27	neutral	0.35	0.5	0.14	neutral	0.5	disease	0.27	neutral	0.43	neutral	1	0.2	neutral	0.79	deleterious	-6	neutral	0.14	neutral	0.06	medium_impact	0.47	medium_impact	-0.33	medium_impact	0.57	0.8	16.98	36.64	0.26	N	0.10	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4012	4012	A	G	MI.12236	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	706	236	T	A	Acc/Gcc	-0.7	0	0	benign	0	neutral	0.68	neutral	2.85	neutral	2.04	deleterious	-2.76	neutral_impact	0.17	0.77	neutral	0.89	neutral	-0.35	0.52	neutral	0.26	0.45	0.12	neutral	0.23	neutral	0.29	neutral	0.42	neutral	2	0.31	neutral	0.84	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.46	medium_impact	-1.04	low_impact	0.41	0.8	16.98	36.64	0.3	N	0.00	polymorphism	1	0.08	rs201610884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4013	4013	C	A	MI.12237	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	707	236	T	N	aCc/aAc	1.6	0	0	benign	0.41	neutral	0.6	neutral	2.72	neutral	-2.21	deleterious	-3.91	high_impact	3.54	0.7	neutral	0.55	neutral	1.95	15.92	deleterious	0.3	0.45	0.39	neutral	0.69	disease	0.38	neutral	0.49	neutral	0	0.37	neutral	0.6	deleterious	-2	neutral	0.35	neutral	-0.6	medium_impact	0.37	medium_impact	1.9	medium_impact	0.51	0.8	16.98	36.64	0.34	N	0.28	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4013	4013	C	G	MI.12238	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	707	236	T	S	aCc/aGc	1.6	0	0	benign	0.12	neutral	0.69	neutral	2.76	neutral	0.39	deleterious	-2.61	low_impact	0.98	0.79	neutral	0.76	neutral	1.69	14.36	neutral	0.35	0.5	0.14	neutral	0.5	disease	0.27	neutral	0.43	neutral	1	0.2	neutral	0.79	deleterious	-6	neutral	0.14	neutral	0.06	medium_impact	0.47	medium_impact	-0.33	medium_impact	0.57	0.8	16.98	36.64	0.26	N	0.10	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4013	4013	C	T	MI.12239	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	707	236	T	I	aCc/aTc	1.6	0	0	benign	0.12	neutral	1	neutral	2.78	neutral	0.52	deleterious	-4.19	low_impact	1.3	0.78	neutral	0.91	neutral	2.12	17.01	deleterious	0.14	0.4	0.13	neutral	0.69	disease	0.29	neutral	0.49	neutral	0	0.12	neutral	0.94	deleterious	-6	neutral	0.16	neutral	0.06	medium_impact	1.96	high_impact	-0.05	medium_impact	0.68	0.85	16.98	36.64	0.26	N	0.14	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9101	9101	T	C	MI.1224	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	575	192	I	T	aTc/aCc	4.76	0.99	0.01	benign	0.01	neutral	1	neutral	4.38	neutral	-0.1	neutral	3.43	neutral_impact	-1.09	0.34	damaging	0.37	neutral	-1.17	0.01	neutral	0.46	0.65	0.32	neutral	0.05	neutral	0.24	neutral	0.2	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.11	neutral	1.14	medium_impact	1.98	high_impact	-2.03	low_impact	0.71	0.9	12.83	11.48	0.8	P	0.67	disease_causing_automatic	0	0.02	rs199476134	Pathogenic	Leber's_optic_atrophy	24682	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	T9101C	LHON	+	-	Reported	4	P	P	P	neutral
chrM	4015	4015	C	G	MI.12240	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	709	237	L	V	Ctc/Gtc	-7.36	0	0	probably_damaging	1	neutral	0.29	neutral	2.24	neutral	-2.44	neutral	-2.47	medium_impact	2.62	0.73	neutral	0.6	neutral	3.51	23.10	deleterious	0.25	0.45	0.28	neutral	0.44	neutral	0.51	disease	0.44	neutral	1	1	deleterious	0.15	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.06	medium_impact	1.1	medium_impact	0.41	0.8	18.87	31.55	0.4	N	0.41	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4015	4015	C	T	MI.12241	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	709	237	L	F	Ctc/Ttc	-7.36	0	0	probably_damaging	1	neutral	0.78	neutral	2.24	neutral	-2.47	deleterious	-3.25	medium_impact	2.41	0.8	neutral	0.9	neutral	3.99	23.60	deleterious	0.18	0.45	0.31	neutral	0.43	neutral	0.42	neutral	0.42	neutral	2	1	deleterious	0.39	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.58	medium_impact	0.92	medium_impact	0.39	0.8	18.87	31.55	0.27	N	0.24	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4015	4015	C	A	MI.12242	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	709	237	L	I	Ctc/Atc	-7.36	0	0	probably_damaging	1	neutral	0.69	neutral	2.28	neutral	-2.14	neutral	-1.58	medium_impact	2.31	0.82	neutral	0.84	neutral	4.11	23.80	deleterious	0.28	0.45	0.28	neutral	0.37	neutral	0.35	neutral	0.42	neutral	2	1	deleterious	0.35	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.47	medium_impact	0.83	medium_impact	0.48	0.8	18.87	31.55	0.29	N	0.39	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4016	4016	T	A	MI.12243	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	710	237	L	H	cTc/cAc	-0.7	0	0	probably_damaging	1	neutral	0.26	neutral	2.09	deleterious	-6.41	deleterious	-6.09	high_impact	4.5	0.7	neutral	0.46	neutral	4.18	23.80	deleterious	0.03	0.35	0.7	disease	0.72	disease	0.69	disease	0.68	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.02	medium_impact	2.74	high_impact	0.22	0.8	18.87	31.55	0.47	N	0.87	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4016	4016	T	C	MI.12244	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	710	237	L	P	cTc/cCc	-0.7	0	0	probably_damaging	1	neutral	0.1	neutral	2.09	deleterious	-6.32	deleterious	-6.18	high_impact	3.94	0.78	neutral	0.44	neutral	4.00	23.60	deleterious	0.02	0.35	0.73	disease	0.75	disease	0.72	disease	0.73	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.26	medium_impact	2.25	high_impact	0.24	0.8	18.87	31.55	0.36	N	0.95	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4016	4016	T	G	MI.12245	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	710	237	L	R	cTc/cGc	-0.7	0	0	probably_damaging	1	neutral	0.17	neutral	2.09	deleterious	-5.77	deleterious	-5.3	high_impact	4.5	0.66	neutral	0.44	neutral	4.29	24.00	deleterious	0.01	0.35	0.71	disease	0.84	disease	0.73	disease	0.76	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	-0.11	medium_impact	2.74	high_impact	0.11	0.8	18.87	31.55	0.5	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4018	4018	A	G	MI.12246	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	712	238	T	A	Acc/Gcc	-8.74	0	0	probably_damaging	1	neutral	0.43	neutral	2.79	neutral	0.59	neutral	-1.79	medium_impact	1.94	0.68	neutral	0.58	neutral	3.58	23.20	deleterious	0.23	0.45	0.15	neutral	0.41	neutral	0.43	neutral	0.45	neutral	1	1	deleterious	0.22	neutral	1	deleterious	0.65	deleterious	-3.57	low_impact	0.21	medium_impact	0.51	medium_impact	0.51	0.8	51.26	9.33	0.31	N	0.65	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4018	4018	A	C	MI.12247	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	712	238	T	P	Acc/Ccc	-8.74	0	0	probably_damaging	1	neutral	0.14	neutral	2.69	deleterious	-3.06	deleterious	-3.29	high_impact	3.94	0.63	neutral	0.3	neutral	3.56	23.10	deleterious	0.05	0.35	0.54	disease	0.83	disease	0.6	disease	0.73	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	-0.17	medium_impact	2.25	high_impact	0.44	0.8	51.26	9.33	0.36	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4018	4018	A	T	MI.12248	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	712	238	T	S	Acc/Tcc	-8.74	0	0	probably_damaging	1	neutral	0.59	neutral	2.79	neutral	-1.31	neutral	0.27	neutral_impact	0.4	0.75	neutral	0.86	neutral	0.65	8.50	deleterious	0.36	0.5	0.23	neutral	0.06	neutral	0.24	neutral	0.21	neutral	6	1	deleterious	0.3	neutral	-2	neutral	0.64	deleterious	-3.57	low_impact	0.36	medium_impact	-0.84	medium_impact	0.57	0.8	51.26	9.33	0.4	N	0.89	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4019	4019	C	T	MI.12249	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	713	238	T	I	aCc/aTc	3.21	0.99	0	probably_damaging	1	neutral	0.62	neutral	2.78	neutral	0.62	deleterious	-3.85	medium_impact	2.12	0.66	neutral	0.45	neutral	4.08	23.70	deleterious	0.12	0.4	0.15	neutral	0.67	disease	0.36	neutral	0.51	disease	0	1	deleterious	0.31	neutral	1	deleterious	0.68	deleterious	-3.57	low_impact	0.39	medium_impact	0.66	medium_impact	0.70	0.85	51.26	9.33	0.38	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9102	9102	C	G	MI.1225	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	576	192	I	M	atC/atG	3.6	0.99	0	possibly_damaging	0.77	neutral	0.29	neutral	4.3	neutral	-1.74	neutral	-0.28	neutral_impact	0.36	0.9	neutral	0.73	neutral	3.23	22.80	deleterious	0.49	0.65	0.33	neutral	0.31	neutral	0.27	neutral	0.46	neutral	1	0.82	neutral	0.26	neutral	-3	neutral	0.57	deleterious	-1.25	low_impact	0.07	medium_impact	-0.79	medium_impact	0.77	0.9	12.83	11.48	0.53	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4019	4019	C	A	MI.12250	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	713	238	T	N	aCc/aAc	3.21	0.99	0	probably_damaging	1	neutral	0.4	neutral	2.7	neutral	-1.81	neutral	-1.8	medium_impact	3.04	0.62	neutral	0.42	neutral	3.78	23.40	deleterious	0.25	0.45	0.49	neutral	0.69	disease	0.46	neutral	0.48	neutral	0	1	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.18	medium_impact	1.47	medium_impact	0.57	0.8	51.26	9.33	0.54	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4019	4019	C	G	MI.12251	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	713	238	T	S	aCc/aGc	3.21	0.99	0	probably_damaging	1	neutral	0.59	neutral	2.79	neutral	-1.31	neutral	0.27	neutral_impact	0.4	0.75	neutral	0.86	neutral	0.85	9.79	deleterious	0.36	0.5	0.23	neutral	0.06	neutral	0.24	neutral	0.21	neutral	6	1	deleterious	0.3	neutral	-2	neutral	0.64	deleterious	-3.57	low_impact	0.36	medium_impact	-0.84	medium_impact	0.57	0.8	51.26	9.33	0.55	P	0.89	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4021	4021	A	C	MI.12252	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	715	239	T	P	Act/Cct	-3	0	0	benign	0.27	neutral	0.12	neutral	2.66	deleterious	-3.64	deleterious	-2.74	high_impact	3.67	0.61	neutral	0.36	neutral	1.65	14.12	neutral	0.04	0.35	0.55	disease	0.82	disease	0.67	disease	0.75	disease	5	0.86	neutral	0.43	neutral	-2	neutral	0.35	neutral	-0.35	medium_impact	-0.21	medium_impact	2.02	high_impact	0.41	0.8	18.87	16.59	0.37	N	0.75	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4021	4021	A	G	MI.12253	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	715	239	T	A	Act/Gct	-3	0	0	benign	0	neutral	0.4	neutral	2.81	neutral	0.05	neutral	-0.08	neutral_impact	0.47	0.86	neutral	0.98	neutral	-0.63	0.11	neutral	0.28	0.45	0.15	neutral	0.12	neutral	0.27	neutral	0.25	neutral	5	0.6	neutral	0.7	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.18	medium_impact	-0.78	medium_impact	0.43	0.8	18.87	16.59	0.43	N	0.01	polymorphism	1	0.01	rs199771084	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4021	4021	A	T	MI.12254	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	715	239	T	S	Act/Tct	-3	0	0	benign	0.01	neutral	0.69	neutral	2.86	neutral	-0.42	neutral	-0.9	neutral_impact	0.7	0.82	neutral	0.88	neutral	0.32	5.86	deleterious	0.33	0.5	0.17	neutral	0.31	neutral	0.24	neutral	0.44	neutral	1	0.3	neutral	0.84	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.47	medium_impact	-0.58	medium_impact	0.60	0.8	18.87	16.59	0.32	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4022	4022	C	G	MI.12255	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	716	239	T	S	aCt/aGt	-0.93	0	0	benign	0.01	neutral	0.69	neutral	2.86	neutral	-0.42	neutral	-0.9	neutral_impact	0.7	0.82	neutral	0.88	neutral	0.50	7.40	deleterious	0.33	0.5	0.17	neutral	0.31	neutral	0.24	neutral	0.44	neutral	1	0.3	neutral	0.84	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.47	medium_impact	-0.58	medium_impact	0.60	0.8	18.87	16.59	0.31	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4022	4022	C	T	MI.12256	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	716	239	T	I	aCt/aTt	-0.93	0	0	benign	0	neutral	0.48	neutral	2.71	neutral	-0.94	neutral	-1.9	medium_impact	2.52	0.88	neutral	0.94	neutral	0.96	10.40	neutral	0.1	0.4	0.31	neutral	0.62	disease	0.34	neutral	0.46	neutral	1	0.51	neutral	0.74	deleterious	-3	neutral	0.16	neutral	2.07	high_impact	0.26	medium_impact	1.01	medium_impact	0.57	0.8	18.87	16.59	0.37	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4022	4022	C	A	MI.12257	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	716	239	T	N	aCt/aAt	-0.93	0	0	benign	0	neutral	0.33	neutral	2.68	deleterious	-3.25	deleterious	-2.72	medium_impact	2.87	0.73	neutral	0.59	neutral	1.72	14.50	neutral	0.24	0.45	0.33	neutral	0.66	disease	0.54	disease	0.67	disease	3	0.67	neutral	0.67	deleterious	-3	neutral	0.18	neutral	2.07	high_impact	0.1	medium_impact	1.32	medium_impact	0.54	0.8	18.87	16.59	0.42	N	0.56	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4024	4024	A	C	MI.12258	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	718	240	T	P	Aca/Cca	-16.09	0	0.03	possibly_damaging	0.86	neutral	0.1	neutral	2.71	neutral	-2.53	deleterious	-2.57	medium_impact	2.9	0.77	neutral	0.38	neutral	1.92	15.70	deleterious	0.05	0.35	0.49	neutral	0.85	disease	0.62	disease	0.79	disease	6	0.95	neutral	0.12	neutral	0	NA	0.67	deleterious	-1.49	low_impact	-0.26	medium_impact	1.34	medium_impact	0.36	0.8	13.84	16.81	0.31	N	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4024	4024	A	T	MI.12259	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	718	240	T	S	Aca/Tca	-16.09	0	0.03	possibly_damaging	0.52	neutral	0.6	neutral	2.77	neutral	-0.64	neutral	-1.41	low_impact	1.86	0.78	neutral	0.66	neutral	1.60	13.83	neutral	0.38	0.5	0.19	neutral	0.5	neutral	0.47	neutral	0.52	disease	0	0.46	neutral	0.54	deleterious	-3	neutral	0.25	neutral	-0.78	medium_impact	0.37	medium_impact	0.44	medium_impact	0.63	0.8	13.84	16.81	0.27	N	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9102	9102	C	A	MI.1226	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	576	192	I	M	atC/atA	3.6	0.99	0	possibly_damaging	0.77	neutral	0.29	neutral	4.3	neutral	-1.74	neutral	-0.28	neutral_impact	0.36	0.9	neutral	0.73	neutral	3.66	23.20	deleterious	0.49	0.65	0.33	neutral	0.31	neutral	0.27	neutral	0.46	neutral	1	0.82	neutral	0.26	neutral	-3	neutral	0.57	deleterious	-1.25	low_impact	0.07	medium_impact	-0.79	medium_impact	0.77	0.9	12.83	11.48	0.53	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4024	4024	A	G	MI.12260	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	718	240	T	A	Aca/Gca	-16.09	0	0.03	benign	0.03	neutral	0.37	neutral	2.81	neutral	0	neutral	-0.87	low_impact	1.58	0.84	neutral	0.81	neutral	1.59	13.78	neutral	0.24	0.45	0.16	neutral	0.39	neutral	0.48	neutral	0.45	neutral	1	0.61	neutral	0.67	deleterious	-6	neutral	0.10	neutral	0.67	medium_impact	0.15	medium_impact	0.19	medium_impact	0.48	0.8	13.84	16.81	0.35	N	0.20	polymorphism	1	0.03	rs41504646	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4025	4025	C	A	MI.12261	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	719	240	T	K	aCa/aAa	1.14	0	0.01	possibly_damaging	0.66	neutral	0.14	neutral	2.74	neutral	-1.47	neutral	-2.49	medium_impact	2.9	0.65	neutral	0.43	neutral	2.63	20.40	deleterious	0.06	0.35	0.21	neutral	0.79	disease	0.59	disease	0.75	disease	5	0.87	neutral	0.24	neutral	0	NA	0.52	deleterious	-1.02	low_impact	-0.17	medium_impact	1.34	medium_impact	0.49	0.8	13.84	16.81	0.41	N	0.78	disease_causing_automatic	0	0.20	rs397515509	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	4025	4025	C	T	MI.12262	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	719	240	T	M	aCa/aTa	1.14	0	0.01	benign	0.14	neutral	0.91	neutral	2.75	neutral	-1.15	neutral	0.09	low_impact	1.07	0.83	neutral	0.78	neutral	2.07	16.64	deleterious	0.1	0.4	0.32	neutral	0.54	disease	0.3	neutral	0.45	neutral	1	0.06	neutral	0.89	deleterious	-6	neutral	0.15	neutral	-0.01	medium_impact	0.84	medium_impact	-0.25	medium_impact	0.59	0.8	13.84	16.81	0.24	N	0.05	disease_causing_automatic	0	0.02	rs397515509	Pathogenic	Leber's_optic_atrophy	76428	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	CPD	2.97	.	.	.	.	.	.	P	.	P	neutral
chrM	4027	4027	A	C	MI.12263	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	721	241	I	L	Atc/Ctc	-6.44	0	0	benign	0.04	neutral	1	neutral	3.27	neutral	2.42	neutral	1.27	neutral_impact	-1.01	0.72	neutral	0.94	neutral	1.10	11.24	neutral	0.24	0.45	0.18	neutral	0.16	neutral	0.28	neutral	0.24	neutral	5	0.04	neutral	0.98	deleterious	-6	neutral	0.11	neutral	0.55	medium_impact	1.96	high_impact	-2.07	low_impact	0.57	0.8	27.04	42.75	0.36	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4027	4027	A	G	MI.12264	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	721	241	I	V	Atc/Gtc	-6.44	0	0	possibly_damaging	0.64	neutral	0.47	neutral	2.72	neutral	0.2	neutral	-0.84	low_impact	1.68	0.87	neutral	0.9	neutral	3.03	22.30	deleterious	0.35	0.5	0.16	neutral	0.33	neutral	0.36	neutral	0.44	neutral	1	0.63	neutral	0.42	neutral	-3	neutral	0.36	neutral	-0.99	medium_impact	0.25	medium_impact	0.28	medium_impact	0.44	0.8	27.04	42.75	0.34	N	0.08	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4027	4027	A	T	MI.12265	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	721	241	I	F	Atc/Ttc	-6.44	0	0	possibly_damaging	0.89	neutral	0.75	neutral	2.64	neutral	-0.82	neutral	-2.09	low_impact	1.26	0.82	neutral	0.55	neutral	3.98	23.60	deleterious	0.18	0.45	0.33	neutral	0.68	disease	0.37	neutral	0.52	disease	0	0.87	neutral	0.43	neutral	-3	neutral	0.67	deleterious	-1.6	low_impact	0.54	medium_impact	-0.09	medium_impact	0.56	0.8	27.04	42.75	0.26	N	0.69	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4028	4028	T	A	MI.12266	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	722	241	I	N	aTc/aAc	-1.16	0	0	probably_damaging	0.98	neutral	0.52	neutral	2.6	deleterious	-3.84	deleterious	-4.81	medium_impact	2.88	0.69	neutral	0.53	neutral	4.70	24.60	deleterious	0.07	0.35	0.69	disease	0.8	disease	0.59	disease	0.75	disease	5	0.98	neutral	0.27	neutral	1	deleterious	0.82	deleterious	-2.34	low_impact	0.29	medium_impact	1.33	medium_impact	0.47	0.8	27.04	42.75	0.27	N	0.92	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4028	4028	T	C	MI.12267	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	722	241	I	T	aTc/aCc	-1.16	0	0	probably_damaging	0.91	neutral	0.66	neutral	2.63	neutral	-2.17	deleterious	-2.96	medium_impact	2.67	0.68	neutral	0.49	neutral	3.52	23.10	deleterious	0.06	0.35	0.44	neutral	0.52	disease	0.53	disease	0.61	disease	2	0.89	neutral	0.38	neutral	1	deleterious	0.67	deleterious	-1.69	low_impact	0.44	medium_impact	1.14	medium_impact	0.31	0.8	27.04	42.75	0.26	N	0.83	polymorphism	1	0.19	.	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4028	4028	T	G	MI.12268	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	722	241	I	S	aTc/aGc	-1.16	0	0	probably_damaging	0.96	neutral	0.64	neutral	2.62	neutral	-2.61	deleterious	-3.88	medium_impact	2.53	0.7	neutral	0.55	neutral	4.32	24.00	deleterious	0.03	0.35	0.52	disease	0.73	disease	0.56	disease	0.7	disease	4	0.95	neutral	0.34	neutral	1	deleterious	0.76	deleterious	-2.05	low_impact	0.42	medium_impact	1.02	medium_impact	0.31	0.8	27.04	42.75	0.23	N	0.87	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4029	4029	C	A	MI.12269	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	723	241	I	M	atC/atA	7.34	0.95	0	probably_damaging	0.92	neutral	0.5	neutral	2.68	neutral	-0.95	neutral	-0.27	neutral_impact	0.43	0.79	neutral	0.9	neutral	2.81	21.40	deleterious	0.25	0.45	0.23	neutral	0.38	neutral	0.32	neutral	0.45	neutral	1	0.91	neutral	0.29	neutral	-2	neutral	0.62	deleterious	-1.75	low_impact	0.28	medium_impact	-0.81	medium_impact	0.53	0.8	27.04	42.75	0.51	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9103	9103	T	C	MI.1227	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	577	193	F	L	Ttc/Ctc	-8.66	0	0	benign	0.01	neutral	1	neutral	4.6	neutral	-0.5	deleterious	-2.5	neutral_impact	-0.32	0.95	neutral	0.85	neutral	0.84	9.74	deleterious	0.44	0.65	0.64	disease	0.28	neutral	0.28	neutral	0.57	disease	1	0.01	neutral	1	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	1.98	high_impact	-1.37	low_impact	0.64	0.9	25.22	21.86	0.23	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4029	4029	C	G	MI.12270	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	723	241	I	M	atC/atG	7.34	0.95	0	probably_damaging	0.92	neutral	0.5	neutral	2.68	neutral	-0.95	neutral	-0.27	neutral_impact	0.43	0.79	neutral	0.9	neutral	2.40	18.79	deleterious	0.25	0.45	0.23	neutral	0.38	neutral	0.32	neutral	0.45	neutral	1	0.91	neutral	0.29	neutral	-2	neutral	0.62	deleterious	-1.75	low_impact	0.28	medium_impact	-0.81	medium_impact	0.53	0.8	27.04	42.75	0.51	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4030	4030	T	C	MI.12271	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	724	242	F	L	Ttc/Ctc	-5.07	0	0	probably_damaging	1	neutral	0.96	neutral	2.22	deleterious	-4.95	deleterious	-5.55	medium_impact	3.26	0.71	neutral	0.59	neutral	4.13	23.80	deleterious	0.06	0.35	0.27	neutral	0.77	disease	0.67	disease	0.68	disease	4	1	deleterious	0.48	deleterious	1	deleterious	0.73	deleterious	-3.57	low_impact	1.05	medium_impact	1.66	medium_impact	0.41	0.8	59.43	10.58	0.34	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4030	4030	T	A	MI.12272	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	724	242	F	I	Ttc/Atc	-5.07	0	0	probably_damaging	1	neutral	0.51	neutral	2.18	deleterious	-6.06	deleterious	-5.55	high_impact	4.38	0.7	neutral	0.6	neutral	4.46	24.20	deleterious	0.07	0.35	0.39	neutral	0.76	disease	0.73	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.29	medium_impact	2.64	high_impact	0.41	0.8	59.43	10.58	0.47	N	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4030	4030	T	G	MI.12273	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	724	242	F	V	Ttc/Gtc	-5.07	0	0	probably_damaging	1	neutral	0.52	neutral	2.19	deleterious	-5.4	deleterious	-6.48	high_impact	4.38	0.62	neutral	0.51	neutral	4.14	23.80	deleterious	0.06	0.35	0.35	neutral	0.8	disease	0.73	disease	0.73	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.29	medium_impact	2.64	high_impact	0.32	0.8	59.43	10.58	0.44	N	0.98	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4031	4031	T	A	MI.12274	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	725	242	F	Y	tTc/tAc	5.5	1	0	probably_damaging	1	neutral	0.67	neutral	2.44	deleterious	-3.66	deleterious	-2.78	medium_impact	3.12	0.69	neutral	0.46	neutral	4.33	24.00	deleterious	0.1	0.4	0.42	neutral	0.64	disease	0.7	disease	0.5	disease	0	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.45	medium_impact	1.54	medium_impact	0.49	0.8	59.43	10.58	0.56	P	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4031	4031	T	C	MI.12275	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	725	242	F	S	tTc/tCc	5.5	1	0	probably_damaging	1	neutral	0.66	neutral	2.19	deleterious	-6.83	deleterious	-7.4	high_impact	4.04	0.6	neutral	0.63	neutral	4.34	24.00	deleterious	0.04	0.35	0.49	neutral	0.82	disease	0.72	disease	0.73	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.44	medium_impact	2.34	high_impact	0.29	0.8	59.43	10.58	0.58	P	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4031	4031	T	G	MI.12276	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	725	242	F	C	tTc/tGc	5.5	1	0	probably_damaging	1	neutral	0.14	neutral	2.14	deleterious	-8.38	deleterious	-7.41	high_impact	4.38	0.66	neutral	0.49	neutral	4.19	23.80	deleterious	0.04	0.35	0.55	disease	0.84	disease	0.75	disease	0.78	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.17	medium_impact	2.64	high_impact	0.22	0.8	59.43	10.58	0.6	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4032	4032	C	G	MI.12277	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	726	242	F	L	ttC/ttG	7.34	1	0	probably_damaging	1	neutral	0.96	neutral	2.22	deleterious	-4.95	deleterious	-5.55	medium_impact	3.26	0.71	neutral	0.59	neutral	4.45	24.20	deleterious	0.06	0.35	0.27	neutral	0.77	disease	0.67	disease	0.68	disease	4	1	deleterious	0.48	deleterious	1	deleterious	0.73	deleterious	-3.57	low_impact	1.05	medium_impact	1.66	medium_impact	0.41	0.8	59.43	10.58	0.51	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4032	4032	C	A	MI.12278	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	726	242	F	L	ttC/ttA	7.34	1	0	probably_damaging	1	neutral	0.96	neutral	2.22	deleterious	-4.95	deleterious	-5.55	medium_impact	3.26	0.71	neutral	0.59	neutral	4.77	24.70	deleterious	0.06	0.35	0.27	neutral	0.77	disease	0.67	disease	0.68	disease	4	1	deleterious	0.48	deleterious	1	deleterious	0.73	deleterious	-3.57	low_impact	1.05	medium_impact	1.66	medium_impact	0.41	0.8	59.43	10.58	0.51	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4033	4033	C	A	MI.12279	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	727	243	L	M	Cta/Ata	-2.31	0	0	benign	0.4	neutral	0.38	neutral	2.26	deleterious	-3.83	neutral	-1.09	low_impact	1.67	0.87	neutral	0.9	neutral	2.51	19.56	deleterious	0.31	0.45	0.54	disease	0.23	neutral	0.4	neutral	0.48	neutral	0	0.56	neutral	0.49	deleterious	-6	neutral	0.29	neutral	-0.59	medium_impact	0.16	medium_impact	0.27	medium_impact	0.63	0.8	23.27	13.76	0.45	N	0.45	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9103	9103	T	G	MI.1228	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	577	193	F	V	Ttc/Gtc	-8.66	0	0	benign	0.22	neutral	0.5	neutral	4.41	neutral	-1.06	deleterious	-3.13	low_impact	1.47	0.88	neutral	0.7	neutral	1.10	11.22	neutral	0.25	0.65	0.65	disease	0.44	neutral	0.4	neutral	0.61	disease	2	0.4	neutral	0.64	deleterious	-6	neutral	0.31	neutral	-0.23	medium_impact	0.29	medium_impact	0.16	medium_impact	0.54	0.9	25.22	21.86	0.29	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4033	4033	C	G	MI.12280	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	727	243	L	V	Cta/Gta	-2.31	0	0	possibly_damaging	0.64	neutral	0.32	neutral	2.32	neutral	-2.63	neutral	-2.23	medium_impact	3.01	0.72	neutral	0.17	damaging	3.46	23.00	deleterious	0.24	0.45	0.33	neutral	0.42	neutral	0.67	disease	0.48	neutral	0	0.72	neutral	0.34	neutral	0	NA	0.55	deleterious	-0.99	medium_impact	0.09	medium_impact	1.44	medium_impact	0.58	0.8	23.27	13.76	0.35	N	0.34	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4034	4034	T	A	MI.12281	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	728	243	L	Q	cTa/cAa	-3.46	0	0	probably_damaging	0.96	neutral	0.07	neutral	2.22	deleterious	-5.24	deleterious	-4.78	high_impact	4.11	0.72	neutral	0.16	damaging	4.14	23.80	deleterious	0.04	0.35	0.77	disease	0.73	disease	0.67	disease	0.69	disease	4	0.99	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-2.05	low_impact	-0.35	medium_impact	2.4	high_impact	0.30	0.8	23.27	13.76	0.38	N	0.94	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4034	4034	T	G	MI.12282	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	728	243	L	R	cTa/cGa	-3.46	0	0	probably_damaging	0.96	neutral	0.09	neutral	2.22	deleterious	-5.11	deleterious	-4.92	high_impact	3.76	0.63	neutral	0.12	damaging	4.24	23.90	deleterious	0.03	0.35	0.77	disease	0.83	disease	0.77	disease	0.79	disease	6	0.98	deleterious	0.07	neutral	2	deleterious	0.84	deleterious	-2.05	low_impact	-0.29	medium_impact	2.1	high_impact	0.28	0.8	23.27	13.76	0.39	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4034	4034	T	C	MI.12283	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	728	243	L	P	cTa/cCa	-3.46	0	0	probably_damaging	0.97	neutral	0.05	neutral	2.23	deleterious	-5.14	deleterious	-5.14	high_impact	3.76	0.64	neutral	0.13	damaging	3.98	23.60	deleterious	0.03	0.35	0.52	disease	0.77	disease	0.77	disease	0.76	disease	5	0.99	deleterious	0.04	neutral	2	deleterious	0.82	deleterious	-2.17	low_impact	-0.44	medium_impact	2.1	high_impact	0.28	0.8	23.27	13.76	0.38	N	0.94	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4036	4036	G	C	MI.12284	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	730	244	G	R	Gga/Cga	-0.7	0.33	0	probably_damaging	0.93	neutral	0.25	neutral	2.36	deleterious	-4.05	deleterious	-5.24	high_impact	3.96	0.68	neutral	0.25	damaging	3.96	23.60	deleterious	0.02	0.35	0.45	neutral	0.82	disease	0.78	disease	0.75	disease	5	0.95	neutral	0.16	neutral	2	deleterious	0.79	deleterious	-1.81	low_impact	0.01	medium_impact	2.27	high_impact	0.45	0.8	22.64	17.2	0.46	N	0.99	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4036	4036	G	T	MI.12285	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	730	244	G	W	Gga/Tga	-0.7	0.33	0	probably_damaging	0.98	neutral	0.14	neutral	2.31	deleterious	-6.59	deleterious	-5.92	high_impact	3.77	0.73	neutral	0.25	damaging	4.48	24.20	deleterious	0.05	0.35	0.85	disease	0.82	disease	0.74	disease	0.8	disease	6	0.99	deleterious	0.08	neutral	2	deleterious	0.85	deleterious	-2.34	low_impact	-0.17	medium_impact	2.1	high_impact	0.12	0.8	22.64	17.2	0.38	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4037	4037	G	C	MI.12286	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	731	244	G	A	gGa/gCa	4.81	1	0	benign	0.05	neutral	0.46	neutral	2.41	deleterious	-3.39	deleterious	-3.87	medium_impact	2.87	0.83	neutral	0.64	neutral	2.10	16.85	deleterious	0.09	0.35	0.36	neutral	0.46	neutral	0.61	disease	0.43	neutral	1	0.5	neutral	0.71	deleterious	-3	neutral	0.22	neutral	0.45	medium_impact	0.24	medium_impact	1.32	medium_impact	0.33	0.8	22.64	17.2	0.59	P	0.80	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4037	4037	G	A	MI.12287	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	731	244	G	E	gGa/gAa	4.81	1	0	possibly_damaging	0.75	neutral	0.2	neutral	2.41	deleterious	-3.37	deleterious	-5.16	high_impact	3.77	0.72	neutral	0.33	neutral	3.97	23.60	deleterious	0.02	0.35	0.37	neutral	0.81	disease	0.78	disease	0.74	disease	5	0.86	neutral	0.23	neutral	1	deleterious	0.73	deleterious	-1.2	low_impact	-0.06	medium_impact	2.1	high_impact	0.20	0.8	22.64	17.2	0.64	P	0.97	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4037	4037	G	T	MI.12288	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	731	244	G	V	gGa/gTa	4.81	1	0	possibly_damaging	0.75	neutral	0.63	neutral	2.35	deleterious	-4.11	deleterious	-6.25	high_impact	3.77	0.72	neutral	0.36	neutral	3.83	23.40	deleterious	0.03	0.35	0.36	neutral	0.74	disease	0.69	disease	0.68	disease	4	0.71	neutral	0.44	neutral	1	deleterious	0.70	deleterious	-1.2	low_impact	0.4	medium_impact	2.1	high_impact	0.16	0.8	22.64	17.2	0.53	N	0.97	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4039	4039	A	C	MI.12289	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	733	245	T	P	Aca/Cca	-5.52	0	0	possibly_damaging	0.81	neutral	0.16	neutral	2.73	neutral	-1.39	neutral	0.86	neutral_impact	-0.97	0.86	neutral	0.98	neutral	1.73	14.58	neutral	0.07	0.35	0.3	neutral	0.35	neutral	0.19	neutral	0.44	neutral	1	0.91	neutral	0.18	neutral	-3	neutral	0.63	deleterious	-1.34	low_impact	-0.13	medium_impact	-2.04	low_impact	0.37	0.8	30.82	36.57	0.49	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9103	9103	T	A	MI.1229	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	577	193	F	I	Ttc/Atc	-8.66	0	0	benign	0.14	neutral	0.59	neutral	4.46	neutral	-1.59	deleterious	-2.62	low_impact	1.07	0.86	neutral	0.61	neutral	1.41	12.83	neutral	0.24	0.65	0.72	disease	0.32	neutral	0.33	neutral	0.64	disease	3	0.3	neutral	0.73	deleterious	-6	neutral	0.29	neutral	-0.01	medium_impact	0.38	medium_impact	-0.18	medium_impact	0.54	0.9	25.22	21.86	0.24	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4039	4039	A	T	MI.12290	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	733	245	T	S	Aca/Tca	-5.52	0	0	benign	0.06	neutral	0.39	neutral	2.86	neutral	0.55	neutral	0.29	neutral_impact	-1.08	0.83	neutral	0.99	neutral	1.62	13.95	neutral	0.32	0.5	0.21	neutral	0.13	neutral	0.2	neutral	0.26	neutral	5	0.57	neutral	0.67	deleterious	-6	neutral	0.13	neutral	0.37	medium_impact	0.17	medium_impact	-2.13	low_impact	0.56	0.8	30.82	36.57	0.48	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4039	4039	A	G	MI.12291	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	733	245	T	A	Aca/Gca	-5.52	0	0	benign	0.02	neutral	0.57	neutral	2.85	neutral	0.47	neutral	0.53	neutral_impact	-0.57	0.79	neutral	0.95	neutral	0.86	9.83	deleterious	0.25	0.45	0.14	neutral	0.06	neutral	0.25	neutral	0.23	neutral	5	0.4	neutral	0.78	deleterious	-6	neutral	0.10	neutral	0.84	medium_impact	0.34	medium_impact	-1.69	low_impact	0.32	0.8	30.82	36.57	0.35	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4040	4040	C	T	MI.12292	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	734	245	T	M	aCa/aTa	-3.69	0	0	benign	0.32	neutral	0.38	neutral	2.7	neutral	-2.57	neutral	-1.61	low_impact	1	0.76	neutral	0.74	neutral	4.04	23.70	deleterious	0.14	0.4	0.28	neutral	0.37	neutral	0.45	neutral	0.45	neutral	1	0.54	neutral	0.53	deleterious	-6	neutral	0.18	neutral	-0.44	medium_impact	0.16	medium_impact	-0.32	medium_impact	0.61	0.8	30.82	36.57	0.35	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4040	4040	C	A	MI.12293	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	734	245	T	K	aCa/aAa	-3.69	0	0	possibly_damaging	0.56	neutral	0.21	neutral	2.74	neutral	-1.21	neutral	-1.34	low_impact	1.43	0.66	neutral	0.52	neutral	4.60	24.40	deleterious	0.08	0.35	0.23	neutral	0.55	disease	0.56	disease	0.68	disease	4	0.78	neutral	0.33	neutral	-3	neutral	0.44	deleterious	-0.85	medium_impact	-0.05	medium_impact	0.06	medium_impact	0.35	0.8	30.82	36.57	0.38	N	0.47	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4042	4042	A	G	MI.12294	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	736	246	T	A	Aca/Gca	-1.62	0	0	benign	0.04	neutral	0.4	neutral	2.82	neutral	0.62	neutral	-0.7	low_impact	1.72	0.85	neutral	0.82	neutral	1.74	14.62	neutral	0.21	0.45	0.15	neutral	0.22	neutral	0.39	neutral	0.38	neutral	2	0.57	neutral	0.68	deleterious	-6	neutral	0.13	neutral	0.55	medium_impact	0.18	medium_impact	0.31	medium_impact	0.29	0.8	30.82	33.51	0.35	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4042	4042	A	T	MI.12295	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	736	246	T	S	Aca/Tca	-1.62	0	0	benign	0.01	neutral	0.49	neutral	2.83	neutral	0.33	neutral	0.33	neutral_impact	-0.57	0.89	neutral	0.97	neutral	0.98	10.56	neutral	0.31	0.45	0.13	neutral	0.06	neutral	0.26	neutral	0.23	neutral	5	0.5	neutral	0.74	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.27	medium_impact	-1.69	low_impact	0.70	0.85	30.82	33.51	0.44	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4042	4042	A	C	MI.12296	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	736	246	T	P	Aca/Cca	-1.62	0	0	benign	0	neutral	0.15	neutral	2.76	neutral	0.34	neutral	-1.31	low_impact	1.13	0.88	neutral	0.79	neutral	2.13	17.04	deleterious	0.07	0.35	0.4	neutral	0.66	disease	0.4	neutral	0.49	neutral	0	0.85	neutral	0.58	deleterious	-6	neutral	0.22	neutral	2.07	high_impact	-0.15	medium_impact	-0.2	medium_impact	0.42	0.8	30.82	33.51	0.39	N	0.12	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4043	4043	C	T	MI.12297	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	737	246	T	M	aCa/aTa	-0.7	0	0	benign	0.36	neutral	0.31	neutral	2.75	neutral	-1.14	neutral	-1.6	low_impact	1.32	0.87	neutral	0.86	neutral	2.68	20.70	deleterious	0.16	0.45	0.27	neutral	0.36	neutral	0.34	neutral	0.45	neutral	1	0.63	neutral	0.48	deleterious	-6	neutral	0.40	neutral	-0.52	medium_impact	0.08	medium_impact	-0.04	medium_impact	0.65	0.8	30.82	33.51	0.42	N	0.04	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4043	4043	C	A	MI.12298	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	737	246	T	K	aCa/aAa	-0.7	0	0	benign	0.11	neutral	0.19	neutral	2.81	neutral	-0.3	neutral	-1.74	low_impact	1.82	0.69	neutral	0.51	neutral	3.22	22.70	deleterious	0.1	0.4	0.22	neutral	0.57	disease	0.49	neutral	0.52	disease	0	0.78	neutral	0.54	deleterious	-6	neutral	0.22	neutral	0.1	medium_impact	-0.08	medium_impact	0.4	medium_impact	0.38	0.8	30.82	33.51	0.44	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4045	4045	T	C	MI.12299	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	739	247	Y	H	Tat/Cat	-7.13	0	0	benign	0.01	neutral	0.35	neutral	2.83	neutral	-0.56	neutral	0.68	neutral_impact	-0.6	0.73	neutral	0.97	neutral	-0.97	0.02	neutral	0.15	0.4	0.12	neutral	0.12	neutral	0.29	neutral	0.27	neutral	5	0.64	neutral	0.67	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.12	medium_impact	-1.71	low_impact	0.28	0.8	31.76	37.78	0.43	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8584	8584	G	C	MI.123	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	58	20	A	P	Gca/Cca	-5.89	0	0.17	possibly_damaging	0.68	neutral	0.2	neutral	4.56	neutral	-2.79	neutral	-2.31	low_impact	0.9	0.81	neutral	0.38	neutral	3.43	23.00	deleterious	0.13	0.65	0.65	disease	0.79	disease	0.6	disease	0.78	disease	6	0.83	neutral	0.26	neutral	-3	neutral	0.73	deleterious	-1.07	low_impact	-0.05	medium_impact	-0.33	medium_impact	0.71	0.9	24.78	23.03	0.24	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9104	9104	T	G	MI.1230	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	578	193	F	C	tTc/tGc	-1.26	0	0	probably_damaging	0.91	neutral	0.08	neutral	4.28	deleterious	-4.49	deleterious	-4.29	medium_impact	2.68	0.77	neutral	0.45	neutral	4.10	23.70	deleterious	0.23	0.65	0.89	disease	0.55	disease	0.44	neutral	0.59	disease	2	0.97	neutral	0.09	neutral	1	deleterious	0.72	deleterious	-1.71	low_impact	-0.31	medium_impact	1.2	medium_impact	0.33	0.9	25.22	21.86	0.35	N	0.83	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4045	4045	T	G	MI.12300	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	739	247	Y	D	Tat/Gat	-7.13	0	0	possibly_damaging	0.47	neutral	0.09	neutral	2.84	neutral	-2.3	deleterious	-2.82	low_impact	1.2	0.87	neutral	0.58	neutral	2.22	17.67	deleterious	0.08	0.35	0.12	neutral	0.61	disease	0.52	disease	0.59	disease	2	0.9	neutral	0.31	neutral	-3	neutral	0.41	neutral	-0.7	medium_impact	-0.29	medium_impact	-0.14	medium_impact	0.21	0.8	31.76	37.78	0.4	N	0.62	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4045	4045	T	A	MI.12301	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	739	247	Y	N	Tat/Aat	-7.13	0	0	benign	0.38	neutral	0.18	neutral	2.85	neutral	-0.83	neutral	-1.54	neutral_impact	0.42	0.86	neutral	0.96	neutral	0.86	9.83	deleterious	0.15	0.4	0.12	neutral	0.42	neutral	0.35	neutral	0.43	neutral	1	0.79	neutral	0.4	neutral	-6	neutral	0.23	neutral	-0.55	medium_impact	-0.09	medium_impact	-0.82	medium_impact	0.26	0.8	31.76	37.78	0.38	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4046	4046	A	C	MI.12302	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	740	247	Y	S	tAt/tCt	-1.62	0	0	benign	0.34	neutral	0.38	neutral	2.89	neutral	-0.68	neutral	-2.02	neutral_impact	-0.16	0.81	neutral	0.8	neutral	0.70	8.82	deleterious	0.1	0.4	0.14	neutral	0.34	neutral	0.35	neutral	0.43	neutral	1	0.55	neutral	0.52	deleterious	-6	neutral	0.26	neutral	-0.48	medium_impact	0.16	medium_impact	-1.33	low_impact	0.24	0.8	31.76	37.78	0.29	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4046	4046	A	G	MI.12303	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	740	247	Y	C	tAt/tGt	-1.62	0	0	benign	0.02	neutral	0.11	neutral	2.78	neutral	-2.82	deleterious	-2.97	low_impact	1.9	0.9	neutral	0.76	neutral	2.14	17.13	deleterious	0.06	0.35	0.5	disease	0.64	disease	0.38	neutral	0.5	neutral	0	0.89	neutral	0.55	deleterious	-6	neutral	0.18	neutral	0.84	medium_impact	-0.23	medium_impact	0.47	medium_impact	0.05	0.8	31.76	37.78	0.43	N	0.55	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4046	4046	A	T	MI.12304	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	740	247	Y	F	tAt/tTt	-1.62	0	0	benign	0.01	neutral	0.76	neutral	2.83	neutral	0.2	neutral	-1.26	low_impact	0.88	0.85	neutral	0.93	neutral	-0.02	2.35	deleterious	0.22	0.45	0.27	neutral	0.24	neutral	0.27	neutral	0.43	neutral	2	0.21	neutral	0.88	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.56	medium_impact	-0.42	medium_impact	0.40	0.8	31.76	37.78	0.32	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4048	4048	G	T	MI.12305	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	742	248	D	Y	Gac/Tac	-4.38	0	0.1	benign	0.23	neutral	0.98	neutral	2.75	neutral	-2.86	neutral	-0.16	neutral_impact	0.18	0.88	neutral	0.87	neutral	-0.42	0.35	neutral	0.08	0.35	0.39	neutral	0.35	neutral	0.26	neutral	0.46	neutral	1	0.18	neutral	0.88	deleterious	-6	neutral	0.32	neutral	-0.26	medium_impact	1.22	medium_impact	-1.03	low_impact	0.14	0.8	25.79	23.77	0.25	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4048	4048	G	A	MI.12306	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	742	248	D	N	Gac/Aac	-4.38	0	0.1	benign	0	neutral	0.37	neutral	2.81	neutral	-0.4	neutral	1.51	neutral_impact	-1.12	0.83	neutral	0.94	neutral	0.26	5.29	deleterious	0.38	0.5	0.13	neutral	0.09	neutral	0.22	neutral	0.29	neutral	4	0.63	neutral	0.69	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	0.15	medium_impact	-2.17	low_impact	0.62	0.8	25.79	23.77	0.34	N	0.02	polymorphism	1	0.01	rs201629275	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4048	4048	G	C	MI.12307	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	742	248	D	H	Gac/Cac	-4.38	0	0.1	benign	0.26	neutral	0.51	neutral	2.76	neutral	-2.02	neutral	0.36	low_impact	0.84	0.8	neutral	0.78	neutral	-0.01	2.50	deleterious	0.12	0.4	0.25	neutral	0.21	neutral	0.3	neutral	0.36	neutral	3	0.39	neutral	0.63	deleterious	-6	neutral	0.18	neutral	-0.32	medium_impact	0.29	medium_impact	-0.46	medium_impact	0.32	0.8	25.79	23.77	0.31	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4049	4049	A	T	MI.12308	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	743	248	D	V	gAc/gTc	-0.47	0	0	benign	0.04	neutral	0.57	neutral	2.8	neutral	-1.58	neutral	0.07	neutral_impact	0.34	0.83	neutral	0.79	neutral	0.11	3.70	deleterious	0.08	0.35	0.29	neutral	0.32	neutral	0.39	neutral	0.44	neutral	1	0.38	neutral	0.77	deleterious	-6	neutral	0.11	neutral	0.55	medium_impact	0.34	medium_impact	-0.89	medium_impact	0.07	0.8	25.79	23.77	0.29	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4049	4049	A	C	MI.12309	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	743	248	D	A	gAc/gCc	-0.47	0	0	benign	0.01	neutral	0.49	neutral	2.85	neutral	-0.51	neutral	-0.32	neutral_impact	0.18	0.83	neutral	0.81	neutral	-0.03	2.30	deleterious	0.12	0.4	0.16	neutral	0.2	neutral	0.39	neutral	0.35	neutral	3	0.5	neutral	0.74	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.27	medium_impact	-1.03	low_impact	0.33	0.8	25.79	23.77	0.33	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9104	9104	T	A	MI.1231	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	578	193	F	Y	tTc/tAc	-1.26	0	0	benign	0.43	neutral	0.3	neutral	4.3	deleterious	-3.33	neutral	-1.82	medium_impact	2.06	0.87	neutral	0.55	neutral	1.44	13.02	neutral	0.26	0.65	0.78	disease	0.35	neutral	0.46	neutral	0.64	disease	3	0.65	neutral	0.44	neutral	-3	neutral	0.53	deleterious	-0.64	medium_impact	0.08	medium_impact	0.67	medium_impact	0.54	0.9	25.22	21.86	0.41	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4049	4049	A	G	MI.12310	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	743	248	D	G	gAc/gGc	-0.47	0	0	benign	0.02	neutral	0.53	neutral	2.78	neutral	-0.07	neutral	-0.68	neutral_impact	-0.63	0.69	neutral	0.63	neutral	0.63	8.37	deleterious	0.13	0.4	0.18	neutral	0.28	neutral	0.44	neutral	0.42	neutral	2	0.45	neutral	0.76	deleterious	-6	neutral	0.09	neutral	0.84	medium_impact	0.3	medium_impact	-1.74	low_impact	0.32	0.8	25.79	23.77	0.32	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4050	4050	C	A	MI.12311	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	744	248	D	E	gaC/gaA	-2.31	0	0	benign	0.02	neutral	0.26	neutral	2.87	neutral	0.02	neutral	-0.08	low_impact	0.84	0.74	neutral	0.65	neutral	0.92	10.19	neutral	0.18	0.45	0.11	neutral	0.26	neutral	0.33	neutral	0.41	neutral	2	0.73	neutral	0.62	deleterious	-6	neutral	0.08	neutral	0.84	medium_impact	0.02	medium_impact	-0.46	medium_impact	0.61	0.8	25.79	23.77	0.45	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4050	4050	C	G	MI.12312	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	744	248	D	E	gaC/gaG	-2.31	0	0	benign	0.02	neutral	0.26	neutral	2.87	neutral	0.02	neutral	-0.08	low_impact	0.84	0.74	neutral	0.65	neutral	0.58	8.04	deleterious	0.18	0.45	0.11	neutral	0.26	neutral	0.33	neutral	0.41	neutral	2	0.73	neutral	0.62	deleterious	-6	neutral	0.08	neutral	0.84	medium_impact	0.02	medium_impact	-0.46	medium_impact	0.61	0.8	25.79	23.77	0.45	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4051	4051	G	C	MI.12313	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	745	249	A	P	Gca/Cca	-3.69	0	0	benign	0	neutral	0.22	neutral	2.73	neutral	-1.55	neutral	2.06	neutral_impact	-2.08	0.81	neutral	0.95	neutral	-0.65	0.10	neutral	0.09	0.35	0.16	neutral	0.18	neutral	0.3	neutral	0.33	neutral	3	0.78	neutral	0.61	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	-0.03	medium_impact	-3	low_impact	0.49	0.8	30.82	42.25	0.32	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4051	4051	G	T	MI.12314	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	745	249	A	S	Gca/Tca	-3.69	0	0	benign	0	neutral	0.44	neutral	2.78	neutral	-0.32	neutral	0.44	neutral_impact	-0.08	0.81	neutral	0.95	neutral	0.58	8.05	deleterious	0.27	0.45	0.25	neutral	0.16	neutral	0.25	neutral	0.29	neutral	4	0.56	neutral	0.72	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	0.22	medium_impact	-1.26	low_impact	0.36	0.8	30.82	42.25	0.41	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4051	4051	G	A	MI.12315	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	745	249	A	T	Gca/Aca	-3.69	0	0	benign	0	neutral	0.4	neutral	2.77	neutral	-0.49	neutral	0.35	neutral_impact	-0.72	0.9	neutral	0.85	neutral	1.04	10.87	neutral	0.24	0.45	0.24	neutral	0.17	neutral	0.38	neutral	0.31	neutral	4	0.6	neutral	0.7	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.18	medium_impact	-1.82	low_impact	0.70	0.85	30.82	42.25	0.39	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4052	4052	C	T	MI.12316	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	746	249	A	V	gCa/gTa	-1.16	0	0	benign	0	neutral	0.51	neutral	2.85	neutral	0.43	neutral	-0.62	neutral_impact	0.24	0.86	neutral	0.83	neutral	1.43	12.97	neutral	0.18	0.45	0.15	neutral	0.3	neutral	0.4	neutral	0.44	neutral	1	0.49	neutral	0.76	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.29	medium_impact	-0.98	medium_impact	0.70	0.85	30.82	42.25	0.31	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4052	4052	C	A	MI.12317	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	746	249	A	E	gCa/gAa	-1.16	0	0	benign	0.04	neutral	0.27	neutral	2.77	neutral	-0.6	neutral	-0.07	low_impact	1.09	0.87	neutral	0.58	neutral	1.52	13.43	neutral	0.06	0.35	0.3	neutral	0.57	disease	0.49	neutral	0.49	neutral	0	0.71	neutral	0.62	deleterious	-6	neutral	0.18	neutral	0.55	medium_impact	0.03	medium_impact	-0.24	medium_impact	0.31	0.8	30.82	42.25	0.39	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4052	4052	C	G	MI.12318	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	746	249	A	G	gCa/gGa	-1.16	0	0	benign	0.04	neutral	0.39	neutral	2.73	neutral	-1.57	neutral	-0.85	neutral_impact	0.34	0.8	neutral	0.7	neutral	0.96	10.45	neutral	0.29	0.45	0.4	neutral	0.31	neutral	0.38	neutral	0.45	neutral	1	0.58	neutral	0.68	deleterious	-6	neutral	0.16	neutral	0.55	medium_impact	0.17	medium_impact	-0.89	medium_impact	0.52	0.8	30.82	42.25	0.33	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4054	4054	C	G	MI.12319	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	748	250	L	V	Ctc/Gtc	-6.44	0	0	benign	0.02	neutral	0.51	neutral	2.74	neutral	-1.07	neutral	-0.55	low_impact	1.62	0.88	neutral	0.78	neutral	-0.20	1.11	neutral	0.31	0.45	0.21	neutral	0.27	neutral	0.41	neutral	0.42	neutral	2	0.46	neutral	0.75	deleterious	-6	neutral	0.10	neutral	0.84	medium_impact	0.29	medium_impact	0.23	medium_impact	0.26	0.8	28.3	26.2	0.35	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9104	9104	T	C	MI.1232	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	578	193	F	S	tTc/tCc	-1.26	0	0	possibly_damaging	0.68	neutral	0.32	neutral	4.32	neutral	-2.89	deleterious	-3.8	neutral_impact	0.62	0.88	neutral	0.65	neutral	2.66	20.50	deleterious	0.27	0.65	0.45	neutral	0.31	neutral	0.42	neutral	0.45	neutral	1	0.74	neutral	0.32	neutral	-3	neutral	0.52	deleterious	-1.07	low_impact	0.11	medium_impact	-0.57	medium_impact	0.52	0.9	25.22	21.86	0.39	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4054	4054	C	A	MI.12320	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	748	250	L	I	Ctc/Atc	-6.44	0	0	benign	0	neutral	0.4	neutral	2.75	neutral	-0.91	neutral	-0.44	low_impact	0.82	0.86	neutral	0.95	neutral	0.58	8.00	deleterious	0.3	0.45	0.23	neutral	0.17	neutral	0.26	neutral	0.3	neutral	4	0.6	neutral	0.7	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.18	medium_impact	-0.47	medium_impact	0.48	0.8	28.3	26.2	0.47	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4054	4054	C	T	MI.12321	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	748	250	L	F	Ctc/Ttc	-6.44	0	0	benign	0	neutral	0.72	neutral	2.69	neutral	-1.4	neutral	-0.7	low_impact	0.86	0.85	neutral	0.92	neutral	-0.07	1.95	neutral	0.24	0.45	0.31	neutral	0.3	neutral	0.26	neutral	0.44	neutral	1	0.27	neutral	0.86	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.51	medium_impact	-0.44	medium_impact	0.48	0.8	28.3	26.2	0.34	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	COSM6716706	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4055	4055	T	G	MI.12322	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	749	250	L	R	cTc/cGc	-4.15	0	0	benign	0	neutral	0.34	neutral	2.7	deleterious	-3.87	neutral	-1.18	medium_impact	3	0.78	neutral	0.48	neutral	0.77	9.28	deleterious	0.04	0.35	0.29	neutral	0.71	disease	0.53	disease	0.63	disease	3	0.66	neutral	0.67	deleterious	-3	neutral	0.18	neutral	2.07	high_impact	0.11	medium_impact	1.43	medium_impact	0.20	0.8	28.3	26.2	0.33	N	0.03	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4055	4055	T	C	MI.12323	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	749	250	L	P	cTc/cCc	-4.15	0	0	benign	0.11	neutral	0.21	neutral	2.69	neutral	-2.82	neutral	-1.61	low_impact	0.96	0.81	neutral	0.69	neutral	0.73	9.02	deleterious	0.04	0.35	0.47	neutral	0.67	disease	0.33	neutral	0.5	disease	0	0.76	neutral	0.55	deleterious	-6	neutral	0.28	neutral	0.1	medium_impact	-0.05	medium_impact	-0.35	medium_impact	0.11	0.8	28.3	26.2	0.37	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4055	4055	T	A	MI.12324	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	749	250	L	H	cTc/cAc	-4.15	0	0	benign	0	neutral	0.54	neutral	2.67	deleterious	-3.97	neutral	-0.72	medium_impact	2.2	0.82	neutral	0.96	neutral	0.46	7.10	deleterious	0.07	0.35	0.28	neutral	0.41	neutral	0.32	neutral	0.44	neutral	1	0.46	neutral	0.77	deleterious	-3	neutral	0.14	neutral	2.07	high_impact	0.31	medium_impact	0.73	medium_impact	0.15	0.8	28.3	26.2	0.33	N	0.01	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4057	4057	T	A	MI.12325	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	751	251	S	T	Tcc/Acc	-9.43	0	0	benign	0.01	neutral	0.41	neutral	2.78	neutral	-0.81	neutral	0.16	neutral_impact	0.8	0.85	neutral	0.96	neutral	0.00	2.57	deleterious	0.34	0.5	0.16	neutral	0.12	neutral	0.27	neutral	0.3	neutral	4	0.58	neutral	0.7	deleterious	-6	neutral	0.08	neutral	1.12	medium_impact	0.19	medium_impact	-0.49	medium_impact	0.49	0.8	28.93	27.72	0.45	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4057	4057	T	C	MI.12326	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	751	251	S	P	Tcc/Ccc	-9.43	0	0	benign	0.41	neutral	0.21	neutral	2.74	neutral	-1.6	neutral	-1.1	neutral_impact	-0.04	0.72	neutral	0.64	neutral	0.72	8.96	deleterious	0.13	0.4	0.3	neutral	0.59	disease	0.28	neutral	0.45	neutral	1	0.76	neutral	0.4	neutral	-6	neutral	0.36	neutral	-0.6	medium_impact	-0.05	medium_impact	-1.22	low_impact	0.26	0.8	28.93	27.72	0.4	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4057	4057	T	G	MI.12327	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	751	251	S	A	Tcc/Gcc	-9.43	0	0	benign	0.01	neutral	0.53	neutral	2.8	neutral	-0.08	neutral	-0.26	low_impact	1.21	0.9	neutral	0.94	neutral	-0.07	1.96	neutral	0.39	0.5	0.14	neutral	0.16	neutral	0.39	neutral	0.3	neutral	4	0.46	neutral	0.76	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.3	medium_impact	-0.13	medium_impact	0.28	0.8	28.93	27.72	0.38	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4058	4058	C	A	MI.12328	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	752	251	S	Y	tCc/tAc	-3.69	0	0	benign	0.17	neutral	1	neutral	2.72	neutral	-2.97	neutral	0.15	low_impact	0.94	0.9	neutral	0.9	neutral	-0.40	0.39	neutral	0.15	0.4	0.32	neutral	0.42	neutral	0.33	neutral	0.45	neutral	1	0.17	neutral	0.92	deleterious	-6	neutral	0.21	neutral	-0.1	medium_impact	1.96	high_impact	-0.37	medium_impact	0.13	0.8	28.93	27.72	0.28	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4058	4058	C	T	MI.12329	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	752	251	S	F	tCc/tTc	-3.69	0	0	benign	0.01	neutral	0.72	neutral	2.75	neutral	-1.94	neutral	0.37	neutral_impact	-0.31	0.85	neutral	0.98	neutral	-0.26	0.83	neutral	0.13	0.4	0.44	neutral	0.33	neutral	0.3	neutral	0.45	neutral	1	0.26	neutral	0.86	deleterious	-6	neutral	0.15	neutral	1.12	medium_impact	0.51	medium_impact	-1.46	low_impact	0.08	0.8	28.93	27.72	0.27	N	0.53	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9105	9105	C	G	MI.1233	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	579	193	F	L	ttC/ttG	0.36	0	0	benign	0.01	neutral	1	neutral	4.6	neutral	-0.5	deleterious	-2.5	neutral_impact	-0.32	0.95	neutral	0.85	neutral	1.09	11.17	neutral	0.44	0.65	0.64	disease	0.28	neutral	0.28	neutral	0.57	disease	1	0.01	neutral	1	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	1.98	high_impact	-1.37	low_impact	0.64	0.9	25.22	21.86	0.22	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4058	4058	C	G	MI.12330	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	752	251	S	C	tCc/tGc	-3.69	0	0	possibly_damaging	0.76	neutral	0.18	neutral	2.7	deleterious	-4.24	neutral	-0.93	low_impact	1.49	0.69	neutral	0.41	neutral	0.82	9.60	deleterious	0.15	0.45	0.6	disease	0.54	disease	0.34	neutral	0.48	neutral	0	0.87	neutral	0.21	neutral	-3	neutral	0.53	deleterious	-1.22	low_impact	-0.09	medium_impact	0.11	medium_impact	0.20	0.8	28.93	27.72	0.4	N	0.44	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4060	4060	C	A	MI.12331	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	754	252	P	T	Cct/Act	-6.9	0	0	benign	0.08	neutral	0.4	neutral	2.82	neutral	-1.81	deleterious	-5.38	low_impact	1.6	0.86	neutral	0.81	neutral	2.77	21.20	deleterious	0.22	0.45	0.2	neutral	0.63	disease	0.22	neutral	0.4	neutral	2	0.55	neutral	0.66	deleterious	-6	neutral	0.16	neutral	0.25	medium_impact	0.18	medium_impact	0.21	medium_impact	0.46	0.8	16.67	19.21	0.37	N	0.45	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4060	4060	C	T	MI.12332	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	754	252	P	S	Cct/Tct	-6.9	0	0	benign	0.2	neutral	0.42	neutral	2.82	neutral	-1.85	deleterious	-5.4	medium_impact	1.97	0.85	neutral	0.91	neutral	3.95	23.60	deleterious	0.24	0.45	0.17	neutral	0.65	disease	0.21	neutral	0.4	neutral	2	0.49	neutral	0.61	deleterious	-3	neutral	0.22	neutral	-0.19	medium_impact	0.2	medium_impact	0.53	medium_impact	0.08	0.8	16.67	19.21	0.37	N	0.44	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4060	4060	C	G	MI.12333	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	754	252	P	A	Cct/Gct	-6.9	0	0	possibly_damaging	0.52	neutral	0.5	neutral	2.87	neutral	-1.32	deleterious	-5.66	medium_impact	2.78	0.83	neutral	0.64	neutral	3.19	22.70	deleterious	0.22	0.45	0.14	neutral	0.53	disease	0.39	neutral	0.52	disease	0	0.51	neutral	0.49	deleterious	0	NA	0.36	neutral	-0.78	medium_impact	0.28	medium_impact	1.24	medium_impact	0.56	0.8	16.67	19.21	0.3	N	0.53	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4061	4061	C	A	MI.12334	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	755	252	P	H	cCt/cAt	0.91	0.01	0	probably_damaging	0.98	neutral	0.54	neutral	2.76	deleterious	-3.52	deleterious	-6.39	medium_impact	3.06	0.73	neutral	0.47	neutral	4.07	23.70	deleterious	0.13	0.4	0.33	neutral	0.75	disease	0.31	neutral	0.57	disease	1	0.97	neutral	0.28	neutral	1	deleterious	0.72	deleterious	-2.34	low_impact	0.31	medium_impact	1.48	medium_impact	0.18	0.8	16.67	19.21	0.31	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4061	4061	C	T	MI.12335	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	755	252	P	L	cCt/cTt	0.91	0.01	0	possibly_damaging	0.83	neutral	0.67	neutral	2.89	neutral	-1.4	deleterious	-7.17	medium_impact	1.97	0.71	neutral	0.54	neutral	4.41	24.10	deleterious	0.19	0.45	0.17	neutral	0.8	disease	0.24	neutral	0.48	neutral	0	0.8	neutral	0.42	neutral	0	NA	0.51	deleterious	-1.4	low_impact	0.45	medium_impact	0.53	medium_impact	0.40	0.8	16.67	19.21	0.3	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4061	4061	C	G	MI.12336	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	755	252	P	R	cCt/cGt	0.91	0.01	0	probably_damaging	0.94	neutral	0.34	neutral	2.79	neutral	-2.76	deleterious	-6.51	high_impact	3.75	0.69	neutral	0.47	neutral	3.72	23.30	deleterious	0.13	0.4	0.16	neutral	0.83	disease	0.57	disease	0.71	disease	4	0.95	neutral	0.2	neutral	2	deleterious	0.67	deleterious	-1.87	low_impact	0.11	medium_impact	2.09	high_impact	0.29	0.8	16.67	19.21	0.43	N	0.94	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4063	4063	G	C	MI.12337	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	757	253	E	Q	Gaa/Caa	-1.16	0	0	possibly_damaging	0.52	neutral	0.29	neutral	2.74	neutral	-0.94	neutral	-1.91	medium_impact	2.19	0.88	neutral	0.24	damaging	2.38	18.67	deleterious	0.27	0.45	0.27	neutral	0.51	disease	0.35	neutral	0.47	neutral	1	0.69	neutral	0.39	neutral	0	NA	0.48	deleterious	-0.78	medium_impact	0.06	medium_impact	0.72	medium_impact	0.61	0.8	18.24	25.06	0.38	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4063	4063	G	A	MI.12338	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	757	253	E	K	Gaa/Aaa	-1.16	0	0	possibly_damaging	0.9	neutral	0.29	neutral	2.77	neutral	-0.43	deleterious	-2.92	medium_impact	2.34	0.74	neutral	0.12	damaging	4.58	24.40	deleterious	0.13	0.4	0.23	neutral	0.77	disease	0.53	disease	0.66	disease	3	0.92	neutral	0.2	neutral	0	NA	0.73	deleterious	-1.65	low_impact	0.06	medium_impact	0.86	medium_impact	0.68	0.85	18.24	25.06	0.34	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4064	4064	A	C	MI.12339	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	758	253	E	A	gAa/gCa	5.27	1	0	possibly_damaging	0.9	neutral	0.5	neutral	2.81	neutral	0	deleterious	-4.38	low_impact	1.74	0.76	neutral	0.16	damaging	3.80	23.40	deleterious	0.16	0.45	0.14	neutral	0.53	disease	0.46	neutral	0.45	neutral	1	0.89	neutral	0.3	neutral	-3	neutral	0.68	deleterious	-1.65	low_impact	0.28	medium_impact	0.33	medium_impact	0.46	0.8	18.24	25.06	0.51	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9105	9105	C	A	MI.1234	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	579	193	F	L	ttC/ttA	0.36	0	0	benign	0.01	neutral	1	neutral	4.6	neutral	-0.5	deleterious	-2.5	neutral_impact	-0.32	0.95	neutral	0.85	neutral	1.40	12.80	neutral	0.44	0.65	0.64	disease	0.28	neutral	0.28	neutral	0.57	disease	1	0.01	neutral	1	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	1.98	high_impact	-1.37	low_impact	0.64	0.9	25.22	21.86	0.22	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4064	4064	A	T	MI.12340	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	758	253	E	V	gAa/gTa	5.27	1	0	probably_damaging	0.98	neutral	0.5	neutral	2.78	neutral	-0.32	deleterious	-5.17	medium_impact	2.27	0.73	neutral	0.14	damaging	4.36	24.10	deleterious	0.09	0.4	0.16	neutral	0.77	disease	0.47	neutral	0.6	disease	2	0.98	neutral	0.26	neutral	1	deleterious	0.73	deleterious	-2.34	low_impact	0.28	medium_impact	0.79	medium_impact	0.37	0.8	18.24	25.06	0.46	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4064	4064	A	G	MI.12341	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	758	253	E	G	gAa/gGa	5.27	1	0	probably_damaging	0.97	neutral	0.34	neutral	2.71	neutral	-1.7	deleterious	-5.05	low_impact	1.19	0.9	neutral	0.35	neutral	4.37	24.10	deleterious	0.13	0.4	0.26	neutral	0.69	disease	0.54	disease	0.53	disease	1	0.97	neutral	0.19	neutral	-2	neutral	0.73	deleterious	-2.17	low_impact	0.11	medium_impact	-0.15	medium_impact	0.30	0.8	18.24	25.06	0.57	N	0.83	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4065	4065	A	C	MI.12342	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	759	253	E	D	gaA/gaC	5.04	1	0	probably_damaging	0.92	neutral	0.21	neutral	2.72	neutral	-1.33	neutral	-1.91	low_impact	1.78	0.81	neutral	0.19	damaging	3.70	23.30	deleterious	0.33	0.5	0.34	neutral	0.46	neutral	0.44	neutral	0.46	neutral	1	0.95	neutral	0.15	neutral	-2	neutral	0.69	deleterious	-1.75	low_impact	-0.05	medium_impact	0.37	medium_impact	0.51	0.8	18.24	25.06	0.59	P	0.88	polymorphism	1	0.03	rs386828932	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4065	4065	A	T	MI.12343	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	759	253	E	D	gaA/gaT	5.04	1	0	probably_damaging	0.92	neutral	0.21	neutral	2.72	neutral	-1.33	neutral	-1.91	low_impact	1.78	0.81	neutral	0.19	damaging	3.81	23.40	deleterious	0.33	0.5	0.34	neutral	0.46	neutral	0.44	neutral	0.46	neutral	1	0.95	neutral	0.15	neutral	-2	neutral	0.69	deleterious	-1.75	low_impact	-0.05	medium_impact	0.37	medium_impact	0.51	0.8	18.24	25.06	0.6	P	0.88	polymorphism	1	0.03	rs386828932	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4066	4066	C	T	MI.12344	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	760	254	L	F	Ctc/Ttc	0.91	0.33	0	benign	0.02	neutral	0.84	neutral	2.66	neutral	-2.37	neutral	-2.27	low_impact	1.7	0.89	neutral	0.85	neutral	2.89	21.80	deleterious	0.18	0.45	0.3	neutral	0.34	neutral	0.26	neutral	0.45	neutral	1	0.12	neutral	0.91	deleterious	-6	neutral	0.15	neutral	0.84	medium_impact	0.68	medium_impact	0.3	medium_impact	0.48	0.8	26.1	19.12	0.29	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4066	4066	C	G	MI.12345	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	760	254	L	V	Ctc/Gtc	0.91	0.33	0	benign	0.18	neutral	0.54	neutral	2.73	neutral	-1.35	neutral	-1.6	medium_impact	2.12	0.88	neutral	0.69	neutral	3.40	23.00	deleterious	0.29	0.45	0.16	neutral	0.31	neutral	0.45	neutral	0.45	neutral	1	0.35	neutral	0.68	deleterious	-3	neutral	0.20	neutral	-0.13	medium_impact	0.31	medium_impact	0.66	medium_impact	0.37	0.8	26.1	19.12	0.3	N	0.32	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4066	4066	C	A	MI.12346	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	760	254	L	I	Ctc/Atc	0.91	0.33	0	benign	0.26	neutral	0.5	neutral	2.78	neutral	-1.26	neutral	-1.01	low_impact	1.26	0.87	neutral	0.94	neutral	3.02	22.30	deleterious	0.31	0.45	0.26	neutral	0.14	neutral	0.27	neutral	0.27	neutral	5	0.4	neutral	0.62	deleterious	-6	neutral	0.24	neutral	-0.32	medium_impact	0.28	medium_impact	-0.09	medium_impact	0.61	0.8	26.1	19.12	0.37	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4067	4067	T	A	MI.12347	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	761	254	L	H	cTc/cAc	-2.77	0	0	benign	0.02	neutral	0.52	neutral	2.64	deleterious	-4.75	deleterious	-4.48	high_impact	3.74	0.77	neutral	0.48	neutral	4.40	24.10	deleterious	0.06	0.35	0.59	disease	0.6	disease	0.59	disease	0.68	disease	4	0.45	neutral	0.75	deleterious	-2	neutral	0.26	neutral	0.84	medium_impact	0.29	medium_impact	2.08	high_impact	0.17	0.8	26.1	19.12	0.34	N	0.86	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4067	4067	T	G	MI.12348	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	761	254	L	R	cTc/cGc	-2.77	0	0	possibly_damaging	0.47	neutral	0.33	neutral	2.67	deleterious	-4.12	deleterious	-4.08	medium_impact	3.4	0.65	neutral	0.37	neutral	4.29	24.00	deleterious	0.03	0.35	0.5	neutral	0.75	disease	0.72	disease	0.73	disease	5	0.63	neutral	0.43	neutral	0	NA	0.59	deleterious	-0.7	medium_impact	0.1	medium_impact	1.78	medium_impact	0.20	0.8	26.1	19.12	0.35	N	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4067	4067	T	C	MI.12349	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	761	254	L	P	cTc/cCc	-2.77	0	0	possibly_damaging	0.55	neutral	0.27	neutral	2.68	deleterious	-3.46	deleterious	-4.78	medium_impact	2.59	0.59	damaging	0.35	neutral	4.04	23.70	deleterious	0.04	0.35	0.33	neutral	0.69	disease	0.64	disease	0.55	disease	1	0.72	neutral	0.36	neutral	0	NA	0.63	deleterious	-0.83	medium_impact	0.03	medium_impact	1.07	medium_impact	0.14	0.8	26.1	19.12	0.31	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9106	9106	A	T	MI.1235	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	580	194	T	S	Aca/Tca	-2.42	0	0	probably_damaging	0.99	neutral	0.18	neutral	4.32	neutral	-1.28	neutral	-1.77	neutral_impact	0	0.87	neutral	0.89	neutral	2.12	16.97	deleterious	0.39	0.65	0.35	neutral	0.23	neutral	0.33	neutral	0.42	neutral	2	0.99	deleterious	0.1	neutral	-2	neutral	0.68	deleterious	-2.65	low_impact	-0.08	medium_impact	-1.1	low_impact	0.62	0.9	15.93	19.05	0.43	N	0.06	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4069	4069	T	G	MI.12350	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	763	255	Y	D	Tac/Gac	-9.66	0	0	possibly_damaging	0.81	neutral	0.2	neutral	2.81	neutral	-1.05	deleterious	-2.54	low_impact	1.34	0.87	neutral	0.63	neutral	2.26	17.88	deleterious	0.08	0.35	0.26	neutral	0.72	disease	0.58	disease	0.71	disease	4	0.89	neutral	0.2	neutral	-3	neutral	0.61	deleterious	-1.34	low_impact	-0.06	medium_impact	-0.02	medium_impact	0.30	0.8	27.99	30.66	0.36	N	0.92	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4069	4069	T	A	MI.12351	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	763	255	Y	N	Tac/Aac	-9.66	0	0	possibly_damaging	0.68	neutral	0.32	neutral	2.84	neutral	-0.86	neutral	-1.88	low_impact	0.82	0.91	neutral	0.87	neutral	0.80	9.45	deleterious	0.11	0.4	0.24	neutral	0.64	disease	0.36	neutral	0.47	neutral	1	0.75	neutral	0.32	neutral	-3	neutral	0.52	deleterious	-1.06	low_impact	0.09	medium_impact	-0.47	medium_impact	0.28	0.8	27.99	30.66	0.41	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4069	4069	T	C	MI.12352	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	763	255	Y	H	Tac/Cac	-9.66	0	0	benign	0.05	neutral	0.51	neutral	2.78	neutral	-1.59	neutral	-1.75	low_impact	1.07	0.89	neutral	0.91	neutral	-0.25	0.87	neutral	0.16	0.45	0.34	neutral	0.45	neutral	0.4	neutral	0.49	neutral	0	0.44	neutral	0.73	deleterious	-6	neutral	0.18	neutral	0.45	medium_impact	0.29	medium_impact	-0.25	medium_impact	0.33	0.8	27.99	30.66	0.37	N	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4070	4070	A	G	MI.12353	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	764	255	Y	C	tAc/tGc	1.6	0	0	probably_damaging	0.94	neutral	0.17	neutral	2.76	neutral	-2.46	neutral	-2.19	medium_impact	2.31	0.95	neutral	0.81	neutral	2.21	17.55	deleterious	0.07	0.35	0.37	neutral	0.74	disease	0.39	neutral	0.54	disease	1	0.97	neutral	0.12	neutral	1	deleterious	0.68	deleterious	-1.87	low_impact	-0.11	medium_impact	0.83	medium_impact	0.09	0.8	27.99	30.66	0.45	N	0.49	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4070	4070	A	C	MI.12354	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	764	255	Y	S	tAc/tCc	1.6	0	0	possibly_damaging	0.65	neutral	0.41	neutral	2.84	neutral	-0.19	neutral	-1.08	neutral_impact	0.12	0.8	neutral	0.96	neutral	0.41	6.66	deleterious	0.08	0.35	0.12	neutral	0.4	neutral	0.38	neutral	0.43	neutral	1	0.67	neutral	0.38	neutral	-3	neutral	0.43	neutral	-1	low_impact	0.19	medium_impact	-1.08	low_impact	0.36	0.8	27.99	30.66	0.35	N	0.80	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4070	4070	A	T	MI.12355	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	764	255	Y	F	tAc/tTc	1.6	0	0	benign	0.01	neutral	0.71	neutral	2.8	neutral	0.23	neutral	0.61	neutral_impact	-0.77	0.78	neutral	0.96	neutral	-0.41	0.37	neutral	0.21	0.45	0.2	neutral	0.16	neutral	0.25	neutral	0.24	neutral	5	0.26	neutral	0.85	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.49	medium_impact	-1.86	low_impact	0.46	0.8	27.99	30.66	0.3	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4072	4072	A	C	MI.12356	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	766	256	T	P	Aca/Cca	-5.07	0	0	probably_damaging	0.96	neutral	0.21	neutral	2.72	neutral	-1.86	deleterious	-3.24	low_impact	1.52	0.76	neutral	0.32	neutral	2.42	18.94	deleterious	0.06	0.35	0.46	neutral	0.74	disease	0.5	neutral	0.54	disease	1	0.97	neutral	0.13	neutral	-2	neutral	0.77	deleterious	-2.05	low_impact	-0.05	medium_impact	0.14	medium_impact	0.43	0.8	54.72	10.65	0.29	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4072	4072	A	T	MI.12357	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	766	256	T	S	Aca/Tca	-5.07	0	0	benign	0.13	neutral	0.43	neutral	2.82	neutral	-1.1	neutral	-1.74	low_impact	1.32	0.86	neutral	0.89	neutral	1.83	15.15	deleterious	0.36	0.5	0.19	neutral	0.21	neutral	0.28	neutral	0.37	neutral	3	0.5	neutral	0.65	deleterious	-6	neutral	0.19	neutral	0.02	medium_impact	0.21	medium_impact	-0.04	medium_impact	0.72	0.85	54.72	10.65	0.42	N	0.08	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4072	4072	A	G	MI.12358	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	766	256	T	A	Aca/Gca	-5.07	0	0	possibly_damaging	0.64	neutral	0.52	neutral	2.8	neutral	-0.05	deleterious	-2.75	medium_impact	2.57	0.82	neutral	0.56	neutral	2.35	18.48	deleterious	0.26	0.45	0.18	neutral	0.37	neutral	0.42	neutral	0.44	neutral	1	0.61	neutral	0.44	neutral	0	NA	0.48	deleterious	-0.99	medium_impact	0.29	medium_impact	1.06	medium_impact	0.45	0.8	54.72	10.65	0.3	N	0.65	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4073	4073	C	T	MI.12359	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	767	256	T	M	aCa/aTa	-0.7	0	0	probably_damaging	0.98	neutral	0.23	neutral	2.74	neutral	-1.66	deleterious	-3.98	medium_impact	3.26	0.67	neutral	0.13	damaging	4.12	23.80	deleterious	0.1	0.4	0.29	neutral	0.68	disease	0.37	neutral	0.5	disease	0	0.99	deleterious	0.13	neutral	1	deleterious	0.68	deleterious	-2.34	low_impact	-0.02	medium_impact	1.66	medium_impact	0.73	0.85	54.72	10.65	0.36	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9106	9106	A	G	MI.1236	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	580	194	T	A	Aca/Gca	-2.42	0	0	probably_damaging	0.99	neutral	0.48	neutral	4.38	neutral	-0.11	neutral	-1.56	neutral_impact	-0.38	0.94	neutral	0.84	neutral	2.03	16.43	deleterious	0.42	0.65	0.28	neutral	0.18	neutral	0.35	neutral	0.3	neutral	4	0.99	deleterious	0.25	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	0.27	medium_impact	-1.42	low_impact	0.45	0.9	15.93	19.05	0.33	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4073	4073	C	A	MI.12360	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	767	256	T	K	aCa/aAa	-0.7	0	0	possibly_damaging	0.83	neutral	0.31	neutral	2.75	neutral	-2.18	deleterious	-3.75	medium_impact	2.81	0.66	neutral	0.14	damaging	4.55	24.40	deleterious	0.06	0.35	0.32	neutral	0.78	disease	0.41	neutral	0.67	disease	3	0.86	neutral	0.24	neutral	0	NA	0.72	deleterious	-1.4	low_impact	0.08	medium_impact	1.27	medium_impact	0.54	0.8	54.72	10.65	0.33	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4075	4075	A	G	MI.12361	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	769	257	T	A	Aca/Gca	-6.44	0	0	benign	0.01	neutral	0.5	neutral	2.8	neutral	0.22	neutral	-0.63	neutral_impact	0.52	0.86	neutral	0.97	neutral	2.19	17.48	deleterious	0.23	0.45	0.18	neutral	0.19	neutral	0.36	neutral	0.37	neutral	3	0.49	neutral	0.75	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.28	medium_impact	-0.73	medium_impact	0.48	0.8	25.79	18.66	0.35	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4075	4075	A	T	MI.12362	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	769	257	T	S	Aca/Tca	-6.44	0	0	benign	0.18	neutral	0.53	neutral	2.76	neutral	-0.71	neutral	-1.12	low_impact	1.31	0.75	neutral	0.68	neutral	2.38	18.69	deleterious	0.36	0.5	0.19	neutral	0.32	neutral	0.25	neutral	0.45	neutral	1	0.36	neutral	0.68	deleterious	-6	neutral	0.19	neutral	-0.13	medium_impact	0.3	medium_impact	-0.04	medium_impact	0.68	0.85	25.79	18.66	0.39	N	0.20	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4075	4075	A	C	MI.12363	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	769	257	T	P	Aca/Cca	-6.44	0	0	possibly_damaging	0.55	neutral	0.33	neutral	2.71	neutral	-1.5	neutral	-2.25	neutral_impact	0.76	0.67	neutral	0.56	neutral	3.54	23.10	deleterious	0.05	0.35	0.45	neutral	0.74	disease	0.53	disease	0.64	disease	3	0.66	neutral	0.39	neutral	-3	neutral	0.61	deleterious	-0.83	medium_impact	0.1	medium_impact	-0.53	medium_impact	0.46	0.8	25.79	18.66	0.31	N	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4076	4076	C	T	MI.12364	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	770	257	T	M	aCa/aTa	-2.08	0	0	benign	0.03	neutral	0.27	neutral	2.76	neutral	-1.19	neutral	1.18	neutral_impact	0.25	0.86	neutral	0.95	neutral	2.15	17.15	deleterious	0.11	0.4	0.25	neutral	0.22	neutral	0.25	neutral	0.41	neutral	2	0.71	neutral	0.62	deleterious	-6	neutral	0.11	neutral	0.67	medium_impact	0.03	medium_impact	-0.97	medium_impact	0.63	0.8	25.79	18.66	0.42	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4076	4076	C	A	MI.12365	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	770	257	T	K	aCa/aAa	-2.08	0	0	benign	0.26	neutral	0.29	neutral	2.74	neutral	-1.87	neutral	-1.91	medium_impact	2.17	0.69	neutral	0.46	neutral	4.63	24.50	deleterious	0.06	0.35	0.34	neutral	0.58	disease	0.61	disease	0.7	disease	4	0.65	neutral	0.52	deleterious	-3	neutral	0.36	neutral	-0.32	medium_impact	0.06	medium_impact	0.71	medium_impact	0.55	0.8	25.79	18.66	0.39	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4078	4078	T	C	MI.12366	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	772	258	Y	H	Tat/Cat	-12.65	0	0	benign	0.29	neutral	0.54	neutral	2.77	neutral	-1.48	neutral	1.38	low_impact	1.2	0.74	neutral	0.51	neutral	2.06	16.57	deleterious	0.19	0.45	0.35	neutral	0.38	neutral	0.36	neutral	0.45	neutral	1	0.36	neutral	0.63	deleterious	-6	neutral	0.22	neutral	-0.39	medium_impact	0.31	medium_impact	-0.14	medium_impact	0.38	0.8	28.62	36.47	0.3	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4078	4078	T	G	MI.12367	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	772	258	Y	D	Tat/Gat	-12.65	0	0	benign	0.07	neutral	0.2	neutral	2.77	neutral	-1.82	neutral	1.65	low_impact	0.85	0.85	neutral	0.68	neutral	2.35	18.52	deleterious	0.06	0.35	0.4	neutral	0.66	disease	0.44	neutral	0.51	disease	0	0.78	neutral	0.57	deleterious	-6	neutral	0.21	neutral	0.3	medium_impact	-0.06	medium_impact	-0.45	medium_impact	0.32	0.8	28.62	36.47	0.3	N	0.26	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4078	4078	T	A	MI.12368	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	772	258	Y	N	Tat/Aat	-12.65	0	0	benign	0	neutral	0.31	neutral	2.8	neutral	-1.03	neutral	4.28	neutral_impact	-2.11	0.67	neutral	0.96	neutral	-0.31	0.63	neutral	0.1	0.4	0.15	neutral	0.15	neutral	0.25	neutral	0.29	neutral	4	0.69	neutral	0.66	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.08	medium_impact	-3.03	low_impact	0.46	0.8	28.62	36.47	0.41	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4079	4079	A	C	MI.12369	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	773	258	Y	S	tAt/tCt	-0.47	0	0	benign	0	neutral	0.4	neutral	2.84	neutral	-0.25	neutral	2.72	neutral_impact	-1.43	0.79	neutral	0.96	neutral	0.17	4.39	deleterious	0.08	0.35	0.14	neutral	0.28	neutral	0.24	neutral	0.41	neutral	2	0.6	neutral	0.7	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.18	medium_impact	-2.44	low_impact	0.35	0.8	28.62	36.47	0.28	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9106	9106	A	C	MI.1237	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	580	194	T	P	Aca/Cca	-2.42	0	0	probably_damaging	1	neutral	0.14	neutral	4.3	neutral	-1.86	deleterious	-3.23	neutral_impact	0.68	0.73	neutral	0.38	neutral	2.50	19.48	deleterious	0.15	0.65	0.59	disease	0.75	disease	0.6	disease	0.61	disease	2	1	deleterious	0.07	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	-0.15	medium_impact	-0.52	medium_impact	0.58	0.9	15.93	19.05	0.26	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4079	4079	A	G	MI.12370	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	773	258	Y	C	tAt/tGt	-0.47	0	0	benign	0	neutral	0.18	neutral	2.77	neutral	-1.91	neutral	-0.4	neutral_impact	0.5	0.78	neutral	0.76	neutral	0.43	6.84	deleterious	0.05	0.35	0.35	neutral	0.63	disease	0.26	neutral	0.5	neutral	0	0.82	neutral	0.59	deleterious	-6	neutral	0.15	neutral	2.07	high_impact	-0.09	medium_impact	-0.75	medium_impact	0.21	0.8	28.62	36.47	0.39	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4079	4079	A	T	MI.12371	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	773	258	Y	F	tAt/tTt	-0.47	0	0	benign	0.11	neutral	0.71	neutral	2.84	neutral	1.01	neutral	-0.53	neutral_impact	-0.46	0.87	neutral	0.84	neutral	1.31	12.33	neutral	0.35	0.5	0.14	neutral	0.3	neutral	0.18	neutral	0.43	neutral	1	0.18	neutral	0.8	deleterious	-6	neutral	0.14	neutral	0.1	medium_impact	0.49	medium_impact	-1.59	low_impact	0.57	0.8	28.62	36.47	0.37	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4081	4081	T	C	MI.12372	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	775	259	F	L	Ttt/Ctt	-5.07	0	0	benign	0.08	neutral	0.95	neutral	2.87	neutral	-1.08	neutral	1.53	neutral_impact	-0.14	0.81	neutral	0.91	neutral	1.58	13.77	neutral	0.17	0.45	0.17	neutral	0.17	neutral	0.27	neutral	0.24	neutral	5	0.02	neutral	0.94	deleterious	-6	neutral	0.12	neutral	0.25	medium_impact	0.99	medium_impact	-1.31	low_impact	0.68	0.85	57.55	10.31	0.25	N	0.92	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	T4081C	LHON	+	-	Reported	1	.	P	P	neutral
chrM	4081	4081	T	A	MI.12373	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	775	259	F	I	Ttt/Att	-5.07	0	0	possibly_damaging	0.63	neutral	0.51	neutral	2.82	neutral	-1.97	neutral	0.44	low_impact	1.52	0.74	neutral	0.42	neutral	3.50	23.10	deleterious	0.12	0.4	0.22	neutral	0.41	neutral	0.38	neutral	0.44	neutral	1	0.61	neutral	0.44	neutral	-3	neutral	0.49	deleterious	-0.97	medium_impact	0.29	medium_impact	0.14	medium_impact	0.51	0.8	57.55	10.31	0.38	N	0.97	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4081	4081	T	G	MI.12374	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	775	259	F	V	Ttt/Gtt	-5.07	0	0	possibly_damaging	0.74	neutral	0.55	neutral	2.84	neutral	-1.82	neutral	-0.43	medium_impact	2.21	0.72	neutral	0.19	damaging	4.22	23.90	deleterious	0.09	0.35	0.21	neutral	0.65	disease	0.43	neutral	0.5	neutral	0	0.71	neutral	0.41	neutral	0	NA	0.53	deleterious	-1.18	low_impact	0.32	medium_impact	0.74	medium_impact	0.35	0.8	57.55	10.31	0.27	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4082	4082	T	C	MI.12375	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	776	259	F	S	tTt/tCt	-0.01	0	0	probably_damaging	0.96	neutral	0.44	neutral	2.77	deleterious	-3.43	deleterious	-2.88	medium_impact	2.44	0.78	neutral	0.15	damaging	4.31	24.00	deleterious	0.05	0.35	0.46	neutral	0.7	disease	0.59	disease	0.7	disease	4	0.95	neutral	0.24	neutral	1	deleterious	0.74	deleterious	-2.05	low_impact	0.22	medium_impact	0.94	medium_impact	0.39	0.8	57.55	10.31	0.23	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4082	4082	T	A	MI.12376	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	776	259	F	Y	tTt/tAt	-0.01	0	0	possibly_damaging	0.89	neutral	0.96	neutral	2.71	deleterious	-3.06	neutral	-1.27	medium_impact	2.87	0.73	neutral	0.16	damaging	4.22	23.90	deleterious	0.16	0.45	0.54	disease	0.53	disease	0.51	disease	0.54	disease	1	0.88	neutral	0.54	deleterious	0	NA	0.69	deleterious	-1.6	low_impact	1.05	medium_impact	1.32	medium_impact	0.62	0.8	57.55	10.31	0.3	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4082	4082	T	G	MI.12377	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	776	259	F	C	tTt/tGt	-0.01	0	0	probably_damaging	0.98	neutral	0.2	neutral	2.69	deleterious	-4.84	neutral	-2.23	high_impact	3.76	0.68	neutral	0.13	damaging	4.19	23.80	deleterious	0.05	0.35	0.65	disease	0.77	disease	0.61	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.76	deleterious	-2.34	low_impact	-0.06	medium_impact	2.1	high_impact	0.25	0.8	57.55	10.31	0.37	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4083	4083	T	A	MI.12378	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	777	259	F	L	ttT/ttA	7.34	0.98	0	benign	0.08	neutral	0.95	neutral	2.87	neutral	-1.08	neutral	1.53	neutral_impact	-0.14	0.81	neutral	0.91	neutral	1.82	15.12	deleterious	0.17	0.45	0.17	neutral	0.17	neutral	0.27	neutral	0.24	neutral	5	0.02	neutral	0.94	deleterious	-6	neutral	0.12	neutral	0.25	medium_impact	0.99	medium_impact	-1.31	low_impact	0.68	0.85	57.55	10.31	0.57	P	0.92	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4083	4083	T	G	MI.12379	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	777	259	F	L	ttT/ttG	7.34	0.98	0	benign	0.08	neutral	0.95	neutral	2.87	neutral	-1.08	neutral	1.53	neutral_impact	-0.14	0.81	neutral	0.91	neutral	1.72	14.51	neutral	0.17	0.45	0.17	neutral	0.17	neutral	0.27	neutral	0.24	neutral	5	0.02	neutral	0.94	deleterious	-6	neutral	0.12	neutral	0.25	medium_impact	0.99	medium_impact	-1.31	low_impact	0.68	0.85	57.55	10.31	0.57	P	0.92	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9107	9107	C	A	MI.1238	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	581	194	T	K	aCa/aAa	-0.8	0	0	probably_damaging	1	neutral	0.06	neutral	4.29	neutral	-2.11	deleterious	-3.1	medium_impact	2.1	0.83	neutral	0.44	neutral	4.55	24.30	deleterious	0.12	0.65	0.42	neutral	0.67	disease	0.68	disease	0.71	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.38	medium_impact	0.7	medium_impact	0.70	0.9	15.93	19.05	0.33	N	0.83	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4084	4084	G	C	MI.12380	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	778	260	V	L	Gtc/Ctc	-8.51	0	0	benign	0.03	neutral	1	neutral	2.81	neutral	0.72	neutral	0.37	neutral_impact	-0.57	0.75	neutral	0.7	neutral	1.71	14.47	neutral	0.19	0.45	0.13	neutral	0.41	neutral	0.4	neutral	0.43	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.10	neutral	0.67	medium_impact	1.96	high_impact	-1.69	low_impact	0.45	0.8	24.53	19.91	0.26	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4084	4084	G	T	MI.12381	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	778	260	V	F	Gtc/Ttc	-8.51	0	0	benign	0.38	neutral	0.89	neutral	2.69	neutral	-0.71	neutral	-1.29	neutral_impact	-0.46	0.71	neutral	0.63	neutral	2.32	18.30	deleterious	0.07	0.35	0.27	neutral	0.54	disease	0.32	neutral	0.44	neutral	1	0.28	neutral	0.76	deleterious	-6	neutral	0.24	neutral	-0.55	medium_impact	0.78	medium_impact	-1.59	low_impact	0.44	0.8	24.53	19.91	0.24	N	0.20	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4084	4084	G	A	MI.12382	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	778	260	V	I	Gtc/Atc	-8.51	0	0	benign	0.01	neutral	0.55	neutral	2.77	neutral	0.2	neutral	-0.01	neutral_impact	-0.66	0.8	neutral	0.96	neutral	0.61	8.19	deleterious	0.3	0.45	0.14	neutral	0.1	neutral	0.29	neutral	0.3	neutral	4	0.43	neutral	0.77	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.32	medium_impact	-1.76	low_impact	0.68	0.85	24.53	19.91	0.31	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4085	4085	T	C	MI.12383	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	779	260	V	A	gTc/gCc	1.37	0	0	benign	0.01	neutral	0.5	neutral	2.76	neutral	-0.8	neutral	-1.66	neutral_impact	-0.94	0.82	neutral	0.96	neutral	0.55	7.81	deleterious	0.09	0.4	0.18	neutral	0.17	neutral	0.34	neutral	0.29	neutral	4	0.49	neutral	0.75	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.28	medium_impact	-2.01	low_impact	0.17	0.8	24.53	19.91	0.36	N	0.03	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4085	4085	T	G	MI.12384	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	779	260	V	G	gTc/gGc	1.37	0	0	benign	0.18	neutral	0.34	neutral	2.65	neutral	-1.98	deleterious	-3.67	neutral_impact	-0.16	0.71	neutral	0.56	neutral	1.98	16.10	deleterious	0.05	0.35	0.39	neutral	0.47	neutral	0.37	neutral	0.45	neutral	1	0.59	neutral	0.58	deleterious	-6	neutral	0.20	neutral	-0.13	medium_impact	0.11	medium_impact	-1.33	low_impact	0.30	0.8	24.53	19.91	0.35	N	0.34	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4085	4085	T	A	MI.12385	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	779	260	V	D	gTc/gAc	1.37	0	0	possibly_damaging	0.47	neutral	0.2	neutral	2.63	deleterious	-4.37	deleterious	-3.63	low_impact	1.26	0.7	neutral	0.5	neutral	2.64	20.50	deleterious	0.02	0.35	0.35	neutral	0.71	disease	0.67	disease	0.74	disease	5	0.77	neutral	0.37	neutral	-3	neutral	0.33	neutral	-0.7	medium_impact	-0.06	medium_impact	-0.09	medium_impact	0.27	0.8	24.53	19.91	0.33	N	0.38	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4087	4087	A	C	MI.12386	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	781	261	T	P	Acc/Ccc	-3.46	0	0	possibly_damaging	0.55	neutral	0.2	neutral	2.71	neutral	-2.31	deleterious	-2.87	medium_impact	2.8	0.82	neutral	0.58	neutral	0.64	8.44	deleterious	0.05	0.35	0.52	disease	0.81	disease	0.54	disease	0.74	disease	5	0.79	neutral	0.33	neutral	0	NA	0.58	deleterious	-0.83	medium_impact	-0.06	medium_impact	1.26	medium_impact	0.37	0.8	17.3	13.67	0.34	N	0.79	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4087	4087	A	G	MI.12387	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	781	261	T	A	Acc/Gcc	-3.46	0	0	benign	0.01	neutral	0.51	neutral	2.8	neutral	0.75	neutral	-1.29	low_impact	0.92	0.91	neutral	0.94	neutral	0.07	3.28	deleterious	0.23	0.45	0.18	neutral	0.28	neutral	0.38	neutral	0.43	neutral	1	0.48	neutral	0.75	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.29	medium_impact	-0.39	medium_impact	0.40	0.8	17.3	13.67	0.32	N	0.17	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4087	4087	A	T	MI.12388	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	781	261	T	S	Acc/Tcc	-3.46	0	0	benign	0.02	neutral	0.41	neutral	2.75	neutral	-0.75	neutral	-1.27	medium_impact	2.11	0.83	neutral	0.77	neutral	-0.02	2.42	deleterious	0.35	0.5	0.28	neutral	0.41	neutral	0.36	neutral	0.45	neutral	1	0.57	neutral	0.7	deleterious	-3	neutral	0.13	neutral	0.84	medium_impact	0.19	medium_impact	0.65	medium_impact	0.49	0.8	17.3	13.67	0.39	N	0.21	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4088	4088	C	G	MI.12389	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	782	261	T	S	aCc/aGc	-2.54	0	0	benign	0.02	neutral	0.41	neutral	2.75	neutral	-0.75	neutral	-1.27	medium_impact	2.11	0.83	neutral	0.77	neutral	0.18	4.45	deleterious	0.35	0.5	0.28	neutral	0.41	neutral	0.36	neutral	0.45	neutral	1	0.57	neutral	0.7	deleterious	-3	neutral	0.13	neutral	0.84	medium_impact	0.19	medium_impact	0.65	medium_impact	0.49	0.8	17.3	13.67	0.39	N	0.21	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9107	9107	C	T	MI.1239	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	581	194	T	M	aCa/aTa	-0.8	0	0	probably_damaging	1	neutral	0.36	neutral	4.33	neutral	-0.92	neutral	-1.36	neutral_impact	0.02	0.93	neutral	0.89	neutral	2.88	21.70	deleterious	0.29	0.65	0.43	neutral	0.29	neutral	0.33	neutral	0.44	neutral	1	1	deleterious	0.18	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.15	medium_impact	-1.08	low_impact	0.73	0.9	15.93	19.05	0.37	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4088	4088	C	T	MI.12390	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	782	261	T	I	aCc/aTc	-2.54	0	0	benign	0.01	neutral	0.4	neutral	2.91	neutral	0.86	neutral	-0.22	neutral_impact	0.15	0.82	neutral	0.92	neutral	-0.15	1.40	neutral	0.12	0.4	0.13	neutral	0.22	neutral	0.26	neutral	0.34	neutral	3	0.59	neutral	0.7	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.18	medium_impact	-1.06	low_impact	0.59	0.8	17.3	13.67	0.35	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4088	4088	C	A	MI.12391	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	782	261	T	N	aCc/aAc	-2.54	0	0	benign	0.38	neutral	0.31	neutral	2.72	neutral	-2.27	neutral	-2.43	medium_impact	2.46	0.69	neutral	0.54	neutral	0.74	9.10	deleterious	0.23	0.45	0.46	neutral	0.66	disease	0.4	neutral	0.49	neutral	0	0.63	neutral	0.47	neutral	-3	neutral	0.28	neutral	-0.55	medium_impact	0.08	medium_impact	0.96	medium_impact	0.64	0.8	17.3	13.67	0.39	N	0.57	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4090	4090	A	G	MI.12392	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	784	262	K	E	Aag/Gag	-8.97	0	0	probably_damaging	1	neutral	0.25	neutral	2.4	deleterious	-3.05	deleterious	-3.68	high_impact	3.55	0.8	neutral	0.66	neutral	4.09	23.70	deleterious	0.09	0.35	0.41	neutral	0.85	disease	0.71	disease	0.73	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.01	medium_impact	1.91	medium_impact	0.29	0.8	21.7	15.68	0.4	N	0.30	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4090	4090	A	C	MI.12393	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	784	262	K	Q	Aag/Cag	-8.97	0	0	probably_damaging	1	neutral	0.24	neutral	2.38	deleterious	-3.21	deleterious	-3.68	high_impact	4.04	0.76	neutral	0.13	damaging	3.57	23.10	deleterious	0.22	0.45	0.49	neutral	0.81	disease	0.68	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.01	medium_impact	2.34	high_impact	0.36	0.8	21.7	15.68	0.33	N	0.62	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4091	4091	A	C	MI.12394	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	785	262	K	T	aAg/aCg	5.5	1	0	probably_damaging	1	neutral	0.5	neutral	2.37	deleterious	-3.71	deleterious	-5.5	high_impact	3.9	0.71	neutral	0.11	damaging	3.82	23.40	deleterious	0.08	0.35	0.54	disease	0.78	disease	0.69	disease	0.7	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.28	medium_impact	2.22	high_impact	0.26	0.8	21.7	15.68	0.59	P	0.87	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4091	4091	A	T	MI.12395	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	785	262	K	M	aAg/aTg	5.5	1	0	probably_damaging	1	neutral	0.34	neutral	2.35	deleterious	-4.77	deleterious	-5.48	medium_impact	3.12	0.77	neutral	0.12	damaging	4.13	23.80	deleterious	0.08	0.35	0.61	disease	0.82	disease	0.73	disease	0.73	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.11	medium_impact	1.54	medium_impact	0.18	0.8	21.7	15.68	0.54	N	0.87	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4092	4092	G	T	MI.12396	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	786	262	K	N	aaG/aaT	6.65	1	0.01	probably_damaging	1	neutral	0.28	neutral	2.36	deleterious	-3.88	deleterious	-4.59	high_impact	3.55	0.75	neutral	0.12	damaging	4.17	23.80	deleterious	0.23	0.45	0.55	disease	0.83	disease	0.72	disease	0.75	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.05	medium_impact	1.91	medium_impact	0.31	0.8	21.7	15.68	0.62	P	0.80	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4092	4092	G	C	MI.12397	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	786	262	K	N	aaG/aaC	6.65	1	0.01	probably_damaging	1	neutral	0.28	neutral	2.36	deleterious	-3.88	deleterious	-4.59	high_impact	3.55	0.75	neutral	0.12	damaging	4.04	23.70	deleterious	0.23	0.45	0.55	disease	0.83	disease	0.72	disease	0.75	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.05	medium_impact	1.91	medium_impact	0.31	0.8	21.7	15.68	0.62	P	0.80	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4093	4093	A	G	MI.12398	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	787	263	T	A	Acc/Gcc	1.6	0.82	0.01	benign	0.01	neutral	0.49	neutral	2.82	neutral	-0.93	neutral	0	neutral_impact	0.66	0.84	neutral	0.93	neutral	-0.90	0.03	neutral	0.25	0.45	0.11	neutral	0.13	neutral	0.3	neutral	0.28	neutral	4	0.5	neutral	0.74	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.27	medium_impact	-0.61	medium_impact	0.33	0.8	10.38	25.7	0.36	N	0.01	polymorphism	1	0.01	rs200180511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4093	4093	A	T	MI.12399	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	787	263	T	S	Acc/Tcc	1.6	0.82	0.01	benign	0.17	neutral	0.5	neutral	2.77	neutral	-1.97	neutral	-1.02	low_impact	1.7	0.81	neutral	0.94	neutral	1.27	12.10	neutral	0.4	0.5	0.23	neutral	0.55	disease	0.33	neutral	0.45	neutral	1	0.4	neutral	0.67	deleterious	-6	neutral	0.23	neutral	-0.1	medium_impact	0.28	medium_impact	0.3	medium_impact	0.71	0.85	10.38	25.7	0.34	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8584	8584	G	T	MI.124	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	58	20	A	S	Gca/Tca	-5.89	0	0.17	benign	0.28	neutral	0.4	neutral	4.65	neutral	-0.84	neutral	-1.34	neutral_impact	0.48	0.88	neutral	0.71	neutral	1.75	14.70	neutral	0.36	0.65	0.35	neutral	0.35	neutral	0.3	neutral	0.47	neutral	1	0.52	neutral	0.56	deleterious	-6	neutral	0.28	neutral	-0.37	medium_impact	0.19	medium_impact	-0.69	medium_impact	0.66	0.9	24.78	23.03	0.36	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9109	9109	A	G	MI.1240	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	583	195	I	V	Att/Gtt	-8.43	0	0	benign	0	neutral	0.62	neutral	4.22	neutral	-0.81	neutral	-0.29	neutral_impact	0.06	0.97	neutral	0.93	neutral	-0.93	0.02	neutral	0.54	0.65	NA	NA	0.09	neutral	0.29	neutral	0.22	neutral	6	0.37	neutral	0.81	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	0.41	medium_impact	-1.05	low_impact	0.44	0.9	20.35	25.84	0.37	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4093	4093	A	C	MI.12400	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	787	263	T	P	Acc/Ccc	1.6	0.82	0.01	possibly_damaging	0.64	neutral	0.29	neutral	2.68	deleterious	-3.93	deleterious	-2.77	medium_impact	3.42	0.62	neutral	0.33	neutral	1.74	14.61	neutral	0.06	0.35	0.52	disease	0.9	disease	0.68	disease	0.78	disease	6	0.75	neutral	0.33	neutral	0	NA	0.59	deleterious	-0.99	medium_impact	0.06	medium_impact	1.8	medium_impact	0.38	0.8	10.38	25.7	0.39	N	0.78	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4094	4094	C	T	MI.12401	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	788	263	T	I	aCc/aTc	-0.47	0	0	benign	0.37	neutral	0.75	neutral	2.8	neutral	-0.43	neutral	-2.12	low_impact	1.78	0.84	neutral	0.84	neutral	1.15	11.50	neutral	0.12	0.4	0.18	neutral	0.64	disease	0.33	neutral	0.46	neutral	1	0.26	neutral	0.69	deleterious	-6	neutral	0.36	neutral	-0.53	medium_impact	0.54	medium_impact	0.37	medium_impact	0.54	0.8	10.38	25.7	0.25	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4094	4094	C	A	MI.12402	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	788	263	T	N	aCc/aAc	-0.47	0	0	possibly_damaging	0.64	neutral	0.38	neutral	2.7	deleterious	-3.57	deleterious	-2.84	medium_impact	2.73	0.59	damaging	0.47	neutral	1.91	15.62	deleterious	0.28	0.45	0.44	neutral	0.82	disease	0.57	disease	0.75	disease	5	0.68	neutral	0.37	neutral	0	NA	0.56	deleterious	-0.99	medium_impact	0.16	medium_impact	1.2	medium_impact	0.64	0.8	10.38	25.7	0.34	N	0.55	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4094	4094	C	G	MI.12403	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	788	263	T	S	aCc/aGc	-0.47	0	0	benign	0.17	neutral	0.5	neutral	2.77	neutral	-1.97	neutral	-1.02	low_impact	1.7	0.81	neutral	0.94	neutral	1.57	13.71	neutral	0.4	0.5	0.23	neutral	0.55	disease	0.33	neutral	0.45	neutral	1	0.4	neutral	0.67	deleterious	-6	neutral	0.23	neutral	-0.1	medium_impact	0.28	medium_impact	0.3	medium_impact	0.71	0.85	10.38	25.7	0.34	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4096	4096	C	G	MI.12404	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	790	264	L	V	Cta/Gta	-11.96	0	0	benign	0.12	neutral	0.57	neutral	2.77	neutral	-1.05	neutral	-0.22	low_impact	1.25	0.82	neutral	0.67	neutral	1.52	13.41	neutral	0.29	0.45	0.14	neutral	0.18	neutral	0.21	neutral	0.33	neutral	3	0.33	neutral	0.73	deleterious	-6	neutral	0.13	neutral	0.06	medium_impact	0.34	medium_impact	-0.1	medium_impact	0.58	0.8	19.5	14.66	0.36	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4096	4096	C	A	MI.12405	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	790	264	L	M	Cta/Ata	-11.96	0	0	probably_damaging	0.96	neutral	0.27	neutral	2.67	neutral	-2.95	neutral	-0.08	low_impact	1.34	0.88	neutral	0.89	neutral	2.55	19.82	deleterious	0.23	0.45	0.37	neutral	0.16	neutral	0.2	neutral	0.3	neutral	4	0.96	neutral	0.16	neutral	-2	neutral	0.64	deleterious	-2.05	low_impact	0.03	medium_impact	-0.02	medium_impact	0.40	0.8	19.5	14.66	0.53	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4097	4097	T	C	MI.12406	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	791	264	L	P	cTa/cCa	-2.08	0	0	probably_damaging	0.98	neutral	0.24	neutral	2.64	deleterious	-4.57	neutral	-1.95	medium_impact	2.46	0.69	neutral	0.36	neutral	3.92	23.50	deleterious	0.04	0.35	0.58	disease	0.81	disease	0.54	disease	0.76	disease	5	0.99	deleterious	0.13	neutral	1	deleterious	0.83	deleterious	-2.34	low_impact	-0.01	medium_impact	0.96	medium_impact	0.23	0.8	19.5	14.66	0.3	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4097	4097	T	A	MI.12407	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	791	264	L	Q	cTa/cAa	-2.08	0	0	probably_damaging	0.98	neutral	0.28	neutral	2.66	deleterious	-3.4	neutral	-1.45	medium_impact	2.88	0.74	neutral	0.45	neutral	4.11	23.70	deleterious	0.06	0.35	0.4	neutral	0.55	disease	0.39	neutral	0.49	neutral	0	0.99	deleterious	0.15	neutral	1	deleterious	0.70	deleterious	-2.34	low_impact	0.05	medium_impact	1.33	medium_impact	0.27	0.8	19.5	14.66	0.42	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4097	4097	T	G	MI.12408	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	791	264	L	R	cTa/cGa	-2.08	0	0	probably_damaging	0.97	neutral	0.35	neutral	2.66	deleterious	-3.97	neutral	-1.64	medium_impact	3.43	0.73	neutral	0.43	neutral	4.27	24.00	deleterious	0.03	0.35	0.47	neutral	0.79	disease	0.54	disease	0.75	disease	5	0.97	neutral	0.19	neutral	1	deleterious	0.78	deleterious	-2.17	low_impact	0.12	medium_impact	1.81	medium_impact	0.18	0.8	19.5	14.66	0.37	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4099	4099	C	A	MI.12409	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	793	265	L	I	Ctt/Att	-8.05	0	0	benign	0.08	neutral	0.6	neutral	2.68	neutral	-0.64	neutral	-0.99	neutral_impact	0.74	0.86	neutral	0.93	neutral	2.94	22.00	deleterious	0.25	0.45	0.25	neutral	0.23	neutral	0.24	neutral	0.43	neutral	1	0.32	neutral	0.76	deleterious	-6	neutral	0.16	neutral	0.25	medium_impact	0.37	medium_impact	-0.54	medium_impact	0.39	0.8	24.21	16.02	0.35	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9109	9109	A	C	MI.1241	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	583	195	I	L	Att/Ctt	-8.43	0	0	benign	0.03	neutral	0.52	neutral	4.26	neutral	-0.59	neutral	-0.95	neutral_impact	-0.05	0.84	neutral	0.68	neutral	-0.28	0.73	neutral	0.29	0.65	NA	NA	0.23	neutral	0.23	neutral	0.2	neutral	6	0.44	neutral	0.75	deleterious	-6	neutral	0.13	neutral	0.68	medium_impact	0.31	medium_impact	-1.14	low_impact	0.51	0.9	20.35	25.84	0.34	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4099	4099	C	G	MI.12410	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	793	265	L	V	Ctt/Gtt	-8.05	0	0	benign	0.4	neutral	0.35	neutral	2.69	neutral	-0.39	neutral	-1.58	medium_impact	1.99	0.89	neutral	0.85	neutral	3.48	23.10	deleterious	0.19	0.45	0.21	neutral	0.41	neutral	0.3	neutral	0.46	neutral	1	0.59	neutral	0.48	deleterious	-3	neutral	0.28	neutral	-0.59	medium_impact	0.12	medium_impact	0.55	medium_impact	0.46	0.8	24.21	16.02	0.44	N	0.33	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4099	4099	C	T	MI.12411	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	793	265	L	F	Ctt/Ttt	-8.05	0	0	benign	0.08	neutral	0.59	neutral	2.69	neutral	-0.49	deleterious	-2.59	low_impact	0.95	0.87	neutral	0.91	neutral	3.98	23.60	deleterious	0.23	0.45	0.26	neutral	0.28	neutral	0.22	neutral	0.44	neutral	1	0.33	neutral	0.76	deleterious	-6	neutral	0.15	neutral	0.25	medium_impact	0.36	medium_impact	-0.36	medium_impact	0.37	0.8	24.21	16.02	0.37	N	0.05	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4100	4100	T	C	MI.12412	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	794	265	L	P	cTt/cCt	-4.38	0	0	probably_damaging	0.95	neutral	0.08	neutral	2.56	deleterious	-4.29	deleterious	-4.96	medium_impact	2.75	0.59	damaging	0.36	neutral	4.05	23.70	deleterious	0.04	0.35	0.65	disease	0.85	disease	0.67	disease	0.72	disease	4	0.98	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-1.95	low_impact	-0.32	medium_impact	1.21	medium_impact	0.29	0.8	24.21	16.02	0.3	N	0.94	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4100	4100	T	G	MI.12413	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	794	265	L	R	cTt/cGt	-4.38	0	0	probably_damaging	0.93	neutral	0.24	neutral	2.57	deleterious	-3.65	deleterious	-4.29	medium_impact	3.44	0.65	neutral	0.4	neutral	4.35	24.10	deleterious	0.03	0.35	0.55	disease	0.85	disease	0.66	disease	0.72	disease	4	0.95	neutral	0.16	neutral	1	deleterious	0.78	deleterious	-1.81	low_impact	-0.01	medium_impact	1.82	medium_impact	0.22	0.8	24.21	16.02	0.34	N	0.91	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4100	4100	T	A	MI.12414	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	794	265	L	H	cTt/cAt	-4.38	0	0	probably_damaging	0.98	neutral	0.14	neutral	2.56	deleterious	-4.24	deleterious	-4.96	high_impact	3.79	0.71	neutral	0.45	neutral	4.35	24.10	deleterious	0.06	0.35	0.64	disease	0.75	disease	0.62	disease	0.68	disease	4	0.99	deleterious	0.08	neutral	2	deleterious	0.78	deleterious	-2.34	low_impact	-0.17	medium_impact	2.12	high_impact	0.22	0.8	24.21	16.02	0.39	N	0.81	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4102	4102	C	G	MI.12415	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	796	266	L	V	Cta/Gta	-8.97	0	0	probably_damaging	1	neutral	0.48	neutral	2.52	neutral	-1.57	deleterious	-2.65	medium_impact	2.08	0.62	neutral	0.53	neutral	3.52	23.10	deleterious	0.2	0.45	0.2	neutral	0.45	neutral	0.3	neutral	0.43	neutral	1	1	deleterious	0.24	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.26	medium_impact	0.63	medium_impact	0.43	0.8	55.97	9.68	0.36	N	0.84	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4102	4102	C	A	MI.12416	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	796	266	L	M	Cta/Ata	-8.97	0	0	probably_damaging	1	neutral	0.78	neutral	2.44	neutral	-2.5	neutral	-1.74	medium_impact	2.36	0.7	neutral	0.64	neutral	3.82	23.40	deleterious	0.17	0.45	0.36	neutral	0.43	neutral	0.28	neutral	0.45	neutral	1	1	deleterious	0.39	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.58	medium_impact	0.87	medium_impact	0.30	0.8	55.97	9.68	0.3	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4103	4103	T	A	MI.12417	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	797	266	L	Q	cTa/cAa	-0.93	0	0	probably_damaging	1	neutral	0.09	neutral	2.37	deleterious	-4.42	deleterious	-5.36	high_impact	4.18	0.66	neutral	0.5	neutral	4.08	23.70	deleterious	0.05	0.35	0.63	disease	0.79	disease	0.54	disease	0.68	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	-0.29	medium_impact	2.46	high_impact	0.20	0.8	55.97	9.68	0.42	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4103	4103	T	G	MI.12418	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	797	266	L	R	cTa/cGa	-0.93	0	0	probably_damaging	1	neutral	0.3	neutral	2.37	deleterious	-4.35	deleterious	-5.36	high_impact	4.18	0.67	neutral	0.45	neutral	4.20	23.90	deleterious	0.03	0.35	0.61	disease	0.88	disease	0.67	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.07	medium_impact	2.46	high_impact	0.24	0.8	55.97	9.68	0.4	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4103	4103	T	C	MI.12419	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	797	266	L	P	cTa/cCa	-0.93	0	0	probably_damaging	1	neutral	0.07	neutral	2.36	deleterious	-4.95	deleterious	-6.27	medium_impact	3.48	0.66	neutral	0.47	neutral	3.96	23.60	deleterious	0.03	0.35	0.69	disease	0.84	disease	0.68	disease	0.72	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.86	deleterious	-3.57	low_impact	-0.35	medium_impact	1.85	medium_impact	0.26	0.8	55.97	9.68	0.32	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9109	9109	A	T	MI.1242	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	583	195	I	F	Att/Ttt	-8.43	0	0	benign	0.36	neutral	0.16	neutral	4.01	deleterious	-3.52	deleterious	-2.94	low_impact	1.16	0.87	neutral	0.37	neutral	2.43	19.04	deleterious	0.32	0.65	NA	NA	0.61	disease	0.38	neutral	0.49	neutral	0	0.81	neutral	0.4	neutral	-6	neutral	0.40	neutral	-0.52	medium_impact	-0.12	medium_impact	-0.1	medium_impact	0.62	0.9	20.35	25.84	0.4	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4105	4105	A	G	MI.12420	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	799	267	T	A	Acc/Gcc	-5.75	0	0	possibly_damaging	0.53	neutral	0.54	neutral	2.81	neutral	0.55	neutral	-1.9	low_impact	1.39	0.71	neutral	0.6	neutral	3.54	23.10	deleterious	0.21	0.45	0.12	neutral	0.53	disease	0.3	neutral	0.44	neutral	1	0.5	neutral	0.51	deleterious	-3	neutral	0.37	neutral	-0.8	medium_impact	0.31	medium_impact	0.03	medium_impact	0.39	0.8	16.98	17.21	0.31	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4105	4105	A	T	MI.12421	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	799	267	T	S	Acc/Tcc	-5.75	0	0	benign	0.13	neutral	0.44	neutral	2.82	neutral	-0.49	neutral	-0.18	neutral_impact	-0.04	0.77	neutral	0.79	neutral	0.83	9.64	deleterious	0.28	0.45	0.16	neutral	0.11	neutral	0.22	neutral	0.28	neutral	4	0.48	neutral	0.66	deleterious	-6	neutral	0.15	neutral	0.02	medium_impact	0.22	medium_impact	-1.22	low_impact	0.47	0.8	16.98	17.21	0.4	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4105	4105	A	C	MI.12422	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	799	267	T	P	Acc/Ccc	-5.75	0	0	benign	0.08	neutral	0.22	neutral	2.72	neutral	-2.37	deleterious	-3.38	medium_impact	2.5	0.68	neutral	0.34	neutral	3.58	23.20	deleterious	0.05	0.35	0.47	neutral	0.93	disease	0.64	disease	0.79	disease	6	0.76	neutral	0.57	deleterious	-3	neutral	0.33	neutral	0.25	medium_impact	-0.03	medium_impact	1	medium_impact	0.28	0.8	16.98	17.21	0.34	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4106	4106	C	T	MI.12423	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	800	267	T	I	aCc/aTc	0.68	0.03	0	benign	0.11	neutral	0.42	neutral	2.86	neutral	1.25	deleterious	-3.69	low_impact	1.18	0.75	neutral	0.55	neutral	4.01	23.60	deleterious	0.13	0.4	0.16	neutral	0.77	disease	0.3	neutral	0.51	disease	0	0.51	neutral	0.66	deleterious	-6	neutral	0.20	neutral	0.1	medium_impact	0.2	medium_impact	-0.16	medium_impact	0.44	0.8	16.98	17.21	0.37	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4106	4106	C	A	MI.12424	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	800	267	T	N	aCc/aAc	0.68	0.03	0	possibly_damaging	0.76	neutral	0.3	neutral	2.73	neutral	-2.17	neutral	-2.08	medium_impact	2.61	0.61	neutral	0.42	neutral	3.90	23.50	deleterious	0.23	0.45	0.41	neutral	0.87	disease	0.51	disease	0.71	disease	4	0.81	neutral	0.27	neutral	0	NA	0.70	deleterious	-1.22	low_impact	0.07	medium_impact	1.09	medium_impact	0.45	0.8	16.98	17.21	0.41	N	0.72	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4106	4106	C	G	MI.12425	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	800	267	T	S	aCc/aGc	0.68	0.03	0	benign	0.13	neutral	0.44	neutral	2.82	neutral	-0.49	neutral	-0.18	neutral_impact	-0.04	0.77	neutral	0.79	neutral	1.02	10.76	neutral	0.28	0.45	0.16	neutral	0.11	neutral	0.22	neutral	0.28	neutral	4	0.48	neutral	0.66	deleterious	-6	neutral	0.15	neutral	0.02	medium_impact	0.22	medium_impact	-1.22	low_impact	0.47	0.8	16.98	17.21	0.43	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4108	4108	T	C	MI.12426	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	802	268	S	P	Tcc/Ccc	-9.66	0	0	possibly_damaging	0.55	neutral	0.2	neutral	2.72	neutral	-2.15	neutral	-1.53	medium_impact	2.27	0.63	neutral	0.4	neutral	4.10	23.70	deleterious	0.08	0.35	0.43	neutral	0.83	disease	0.59	disease	0.79	disease	6	0.79	neutral	0.33	neutral	0	NA	0.66	deleterious	-0.83	medium_impact	-0.06	medium_impact	0.79	medium_impact	0.30	0.8	25.16	28.89	0.34	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4108	4108	T	G	MI.12427	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	802	268	S	A	Tcc/Gcc	-9.66	0	0	benign	0.01	neutral	0.71	neutral	2.81	neutral	0.39	neutral	0.34	low_impact	0.96	0.85	neutral	0.97	neutral	2.34	18.44	deleterious	0.22	0.45	0.16	neutral	0.21	neutral	0.34	neutral	0.36	neutral	3	0.27	neutral	0.85	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	0.49	medium_impact	-0.35	medium_impact	0.34	0.8	25.16	28.89	0.31	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4108	4108	T	A	MI.12428	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	802	268	S	T	Tcc/Acc	-9.66	0	0	benign	0.01	neutral	0.61	neutral	2.81	neutral	-0.37	neutral	0.39	neutral_impact	0.3	0.8	neutral	0.98	neutral	2.29	18.11	deleterious	0.24	0.45	0.16	neutral	0.15	neutral	0.25	neutral	0.29	neutral	4	0.37	neutral	0.8	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	0.38	medium_impact	-0.93	medium_impact	0.33	0.8	25.16	28.89	0.34	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4109	4109	C	G	MI.12429	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	803	268	S	C	tCc/tGc	-0.7	0	0	possibly_damaging	0.84	neutral	0.16	neutral	2.72	neutral	-1.62	neutral	-0.59	low_impact	1.8	0.85	neutral	0.65	neutral	3.72	23.30	deleterious	0.08	0.35	0.31	neutral	0.63	disease	0.45	neutral	0.5	disease	0	0.92	neutral	0.16	neutral	-3	neutral	0.57	deleterious	-1.43	low_impact	-0.13	medium_impact	0.38	medium_impact	0.26	0.8	25.16	28.89	0.37	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9110	9110	T	C	MI.1243	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	584	195	I	T	aTt/aCt	-0.8	0	0.01	benign	0.19	neutral	0.16	neutral	4.02	deleterious	-3.21	deleterious	-2.61	low_impact	1.48	0.96	neutral	0.81	neutral	0.51	7.48	deleterious	0.35	0.65	NA	NA	0.32	neutral	0.37	neutral	0.17	neutral	7	0.81	neutral	0.49	deleterious	-6	neutral	0.20	neutral	-0.16	medium_impact	-0.12	medium_impact	0.17	medium_impact	0.65	0.9	20.35	25.84	0.45	N	1.00	polymorphism	1	0.07	.	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4109	4109	C	A	MI.12430	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	803	268	S	Y	tCc/tAc	-0.7	0	0	possibly_damaging	0.79	neutral	1	neutral	2.76	neutral	-0.82	neutral	-1.01	low_impact	0.98	0.77	neutral	0.57	neutral	4.16	23.80	deleterious	0.08	0.35	0.29	neutral	0.62	disease	0.34	neutral	0.47	neutral	1	0.79	neutral	0.61	deleterious	-3	neutral	0.58	deleterious	-1.29	low_impact	1.96	high_impact	-0.33	medium_impact	0.28	0.8	25.16	28.89	0.21	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4109	4109	C	T	MI.12431	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	803	268	S	F	tCc/tTc	-0.7	0	0	possibly_damaging	0.47	neutral	0.92	neutral	2.91	neutral	2.14	neutral	-0.57	neutral_impact	-0.62	0.87	neutral	0.88	neutral	3.21	22.70	deleterious	0.1	0.4	0.15	neutral	0.29	neutral	0.3	neutral	0.42	neutral	2	0.39	neutral	0.73	deleterious	-3	neutral	0.44	deleterious	-0.7	medium_impact	0.87	medium_impact	-1.73	low_impact	0.15	0.8	25.16	28.89	0.32	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4111	4111	C	A	MI.12432	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	805	269	L	M	Ctg/Atg	-11.5	0	0	benign	0.4	neutral	0.23	neutral	2.64	neutral	-1.91	neutral	-0.4	low_impact	1.4	0.87	neutral	0.93	neutral	2.56	19.86	deleterious	0.23	0.45	0.4	neutral	0.15	neutral	0.28	neutral	0.31	neutral	4	0.73	neutral	0.42	neutral	-6	neutral	0.25	neutral	-0.59	medium_impact	-0.02	medium_impact	0.03	medium_impact	0.40	0.8	22.64	19.17	0.51	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4111	4111	C	G	MI.12433	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	805	269	L	V	Ctg/Gtg	-11.5	0	0	benign	0.4	neutral	0.5	neutral	2.77	neutral	-0.2	neutral	-0.23	low_impact	1.7	0.87	neutral	0.88	neutral	1.91	15.67	deleterious	0.19	0.45	0.13	neutral	0.13	neutral	0.27	neutral	0.27	neutral	5	0.44	neutral	0.55	deleterious	-6	neutral	0.23	neutral	-0.59	medium_impact	0.28	medium_impact	0.3	medium_impact	0.37	0.8	22.64	19.17	0.39	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4112	4112	T	C	MI.12434	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	806	269	L	P	cTg/cCg	-8.05	0	0	probably_damaging	0.95	neutral	0.2	neutral	2.57	deleterious	-4.01	deleterious	-2.96	high_impact	3.76	0.69	neutral	0.42	neutral	3.98	23.60	deleterious	0.05	0.35	0.63	disease	0.8	disease	0.59	disease	0.73	disease	5	0.97	neutral	0.13	neutral	2	deleterious	0.80	deleterious	-1.95	low_impact	-0.06	medium_impact	2.1	high_impact	0.24	0.8	22.64	19.17	0.39	N	0.79	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4112	4112	T	G	MI.12435	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	806	269	L	R	cTg/cGg	-8.05	0	0	probably_damaging	0.93	neutral	0.35	neutral	2.58	deleterious	-3.66	deleterious	-2.71	high_impact	3.76	0.73	neutral	0.5	neutral	4.26	23.90	deleterious	0.05	0.35	0.54	disease	0.74	disease	0.58	disease	0.7	disease	4	0.94	neutral	0.21	neutral	2	deleterious	0.73	deleterious	-1.81	low_impact	0.12	medium_impact	2.1	high_impact	0.15	0.8	22.64	19.17	0.4	N	0.48	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4112	4112	T	A	MI.12436	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	806	269	L	Q	cTg/cAg	-8.05	0	0	probably_damaging	0.93	neutral	0.29	neutral	2.58	deleterious	-3.88	deleterious	-2.5	high_impact	3.76	0.74	neutral	0.56	neutral	4.27	23.90	deleterious	0.08	0.35	0.56	disease	0.58	disease	0.44	neutral	0.48	neutral	0	0.94	neutral	0.18	neutral	2	deleterious	0.68	deleterious	-1.81	low_impact	0.06	medium_impact	2.1	high_impact	0.17	0.8	22.64	19.17	0.46	N	0.42	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4114	4114	T	C	MI.12437	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	808	270	F	L	Ttc/Ctc	-9.2	0	0	possibly_damaging	0.8	neutral	0.76	neutral	2.72	neutral	-1	deleterious	-5.37	medium_impact	2.73	0.67	neutral	0.16	damaging	4.12	23.80	deleterious	0.11	0.4	0.17	neutral	0.79	disease	0.64	disease	0.68	disease	4	0.77	neutral	0.48	deleterious	0	NA	0.59	deleterious	-1.32	low_impact	0.56	medium_impact	1.2	medium_impact	0.26	0.8	60.38	10.13	0.32	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4114	4114	T	A	MI.12438	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	808	270	F	I	Ttc/Atc	-9.2	0	0	probably_damaging	0.91	neutral	0.51	neutral	2.65	neutral	-1.11	deleterious	-5.37	medium_impact	2.27	0.72	neutral	0.2	damaging	4.51	24.30	deleterious	0.13	0.4	0.18	neutral	0.75	disease	0.66	disease	0.68	disease	4	0.9	neutral	0.3	neutral	1	deleterious	0.68	deleterious	-1.69	low_impact	0.29	medium_impact	0.79	medium_impact	0.24	0.8	60.38	10.13	0.29	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4114	4114	T	G	MI.12439	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	808	270	F	V	Ttc/Gtc	-9.2	0	0	possibly_damaging	0.88	neutral	0.59	neutral	2.67	neutral	-1.34	deleterious	-6.26	medium_impact	2.86	0.62	neutral	0.17	damaging	4.16	23.80	deleterious	0.11	0.4	0.19	neutral	0.81	disease	0.67	disease	0.69	disease	4	0.86	neutral	0.36	neutral	0	NA	0.62	deleterious	-1.56	low_impact	0.36	medium_impact	1.31	medium_impact	0.26	0.8	60.38	10.13	0.33	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9110	9110	T	A	MI.1244	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	584	195	I	N	aTt/aAt	-0.8	0	0.01	possibly_damaging	0.78	deleterious	0	neutral	3.98	deleterious	-4.87	deleterious	-4.79	medium_impact	3.29	0.84	neutral	0.36	neutral	4.41	24.10	deleterious	0.24	0.65	NA	NA	0.65	disease	0.57	disease	0.7	disease	4	1	deleterious	0.11	neutral	4	deleterious	0.62	deleterious	-1.28	low_impact	-1.4	low_impact	1.72	medium_impact	0.55	0.9	20.35	25.84	0.39	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4115	4115	T	A	MI.12440	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	809	270	F	Y	tTc/tAc	7.34	1	0	probably_damaging	0.92	neutral	0.96	neutral	2.63	neutral	-2.3	deleterious	-2.68	medium_impact	2.69	0.69	neutral	0.17	damaging	4.40	24.10	deleterious	0.17	0.45	0.35	neutral	0.69	disease	0.63	disease	0.5	disease	0	0.92	neutral	0.52	deleterious	1	deleterious	0.70	deleterious	-1.75	low_impact	1.05	medium_impact	1.16	medium_impact	0.37	0.8	60.38	10.13	0.53	N	0.88	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4115	4115	T	G	MI.12441	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	809	270	F	C	tTc/tGc	7.34	1	0	probably_damaging	0.98	neutral	0.17	neutral	2.57	deleterious	-4.27	deleterious	-7.16	high_impact	4.18	0.69	neutral	0.16	damaging	4.21	23.90	deleterious	0.08	0.35	0.58	disease	0.82	disease	0.69	disease	0.71	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.75	deleterious	-2.34	low_impact	-0.11	medium_impact	2.46	high_impact	0.14	0.8	60.38	10.13	0.63	P	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4115	4115	T	C	MI.12442	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	809	270	F	S	tTc/tCc	7.34	1	0	benign	0.2	neutral	0.45	neutral	2.65	neutral	-2.12	deleterious	-7.15	medium_impact	3.49	0.71	neutral	0.22	damaging	4.35	24.10	deleterious	0.06	0.35	0.3	neutral	0.82	disease	0.63	disease	0.68	disease	4	0.46	neutral	0.63	deleterious	-3	neutral	0.30	neutral	-0.19	medium_impact	0.23	medium_impact	1.86	medium_impact	0.26	0.8	60.38	10.13	0.59	P	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4116	4116	C	G	MI.12443	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	810	270	F	L	ttC/ttG	7.34	1	0	possibly_damaging	0.8	neutral	0.76	neutral	2.72	neutral	-1	deleterious	-5.37	medium_impact	2.73	0.67	neutral	0.16	damaging	4.47	24.20	deleterious	0.11	0.4	0.17	neutral	0.79	disease	0.64	disease	0.68	disease	4	0.77	neutral	0.48	deleterious	0	NA	0.59	deleterious	-1.32	low_impact	0.56	medium_impact	1.2	medium_impact	0.26	0.8	60.38	10.13	0.52	P	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4116	4116	C	A	MI.12444	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	810	270	F	L	ttC/ttA	7.34	1	0	possibly_damaging	0.8	neutral	0.76	neutral	2.72	neutral	-1	deleterious	-5.37	medium_impact	2.73	0.67	neutral	0.16	damaging	4.76	24.70	deleterious	0.11	0.4	0.17	neutral	0.79	disease	0.64	disease	0.68	disease	4	0.77	neutral	0.48	deleterious	0	NA	0.59	deleterious	-1.32	low_impact	0.56	medium_impact	1.2	medium_impact	0.26	0.8	60.38	10.13	0.53	P	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4117	4117	T	A	MI.12445	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	811	271	L	M	Tta/Ata	-0.93	0	0.04	probably_damaging	1	neutral	0.13	neutral	2.55	neutral	-2.69	neutral	-1.75	low_impact	1.88	0.77	neutral	0.16	damaging	3.64	23.20	deleterious	0.26	0.45	0.34	neutral	0.55	disease	0.56	disease	0.63	disease	3	1	deleterious	0.07	neutral	-2	neutral	0.69	deleterious	-3.57	low_impact	-0.19	medium_impact	0.45	medium_impact	0.43	0.8	60.06	10.49	0.28	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4117	4117	T	G	MI.12446	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	811	271	L	V	Tta/Gta	-0.93	0	0.04	probably_damaging	1	neutral	0.22	neutral	2.83	neutral	0.14	deleterious	-2.56	low_impact	1.94	0.68	neutral	0.15	damaging	3.47	23.00	deleterious	0.19	0.45	0.15	neutral	0.48	neutral	0.35	neutral	0.42	neutral	2	1	deleterious	0.11	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	-0.03	medium_impact	0.51	medium_impact	0.34	0.8	60.06	10.49	0.32	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4118	4118	T	C	MI.12447	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	812	271	L	S	tTa/tCa	-0.47	0	0	probably_damaging	1	neutral	0.15	neutral	2.54	deleterious	-3.3	deleterious	-5.29	high_impact	3.79	0.73	neutral	0.15	damaging	3.89	23.50	deleterious	0.08	0.35	0.31	neutral	0.74	disease	0.59	disease	0.67	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	-0.15	medium_impact	2.12	high_impact	0.23	0.8	60.06	10.49	0.32	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	COSM1155628	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4118	4118	T	G	MI.12448	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	812	271	L	W	tTa/tGa	-0.47	0	0	probably_damaging	1	neutral	0.23	neutral	2.51	deleterious	-5.66	deleterious	-5.33	high_impact	4.13	0.74	neutral	0.13	damaging	3.90	23.50	deleterious	0.06	0.35	0.72	disease	0.8	disease	0.61	disease	0.68	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	-0.02	medium_impact	2.42	high_impact	0.19	0.8	60.06	10.49	0.34	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4119	4119	A	C	MI.12449	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	813	271	L	F	ttA/ttC	7.34	1	0	probably_damaging	1	neutral	0.41	neutral	2.54	neutral	-2.94	deleterious	-3.52	medium_impact	2.71	0.7	neutral	0.12	damaging	3.71	23.30	deleterious	0.19	0.45	0.39	neutral	0.69	disease	0.59	disease	0.66	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.19	medium_impact	1.18	medium_impact	0.37	0.8	60.06	10.49	0.56	P	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9110	9110	T	G	MI.1245	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	584	195	I	S	aTt/aGt	-0.8	0	0.01	possibly_damaging	0.44	neutral	0.05	neutral	4.03	neutral	-2.99	deleterious	-3.75	medium_impact	2.1	0.81	neutral	0.42	neutral	2.71	20.90	deleterious	0.27	0.65	NA	NA	0.63	disease	0.56	disease	0.62	disease	2	0.94	neutral	0.31	neutral	0	NA	0.30	neutral	-0.66	medium_impact	-0.43	medium_impact	0.7	medium_impact	0.58	0.9	20.35	25.84	0.34	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4119	4119	A	T	MI.12450	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	813	271	L	F	ttA/ttT	7.34	1	0	probably_damaging	1	neutral	0.41	neutral	2.54	neutral	-2.94	deleterious	-3.52	medium_impact	2.71	0.7	neutral	0.12	damaging	3.72	23.30	deleterious	0.19	0.45	0.39	neutral	0.69	disease	0.59	disease	0.66	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.19	medium_impact	1.18	medium_impact	0.37	0.8	60.06	10.49	0.57	P	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4120	4120	T	C	MI.12451	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	814	272	W	R	Tga/Cga	0.45	0.99	0	probably_damaging	0.96	neutral	0.43	neutral	2.66	deleterious	-3.94	deleterious	-12.58	high_impact	4.07	0.71	neutral	0.08	damaging	3.71	23.30	deleterious	0.04	0.35	0.49	neutral	0.89	disease	0.77	disease	0.78	disease	6	0.95	neutral	0.24	neutral	2	deleterious	0.76	deleterious	-2.05	low_impact	0.21	medium_impact	2.37	high_impact	0.06	0.8	58.81	10.42	0.55	P	0.98	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4120	4120	T	G	MI.12452	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	814	272	W	G	Tga/Gga	0.45	0.99	0	probably_damaging	0.91	neutral	0.39	neutral	2.65	deleterious	-3.83	deleterious	-11.68	high_impact	4.07	0.73	neutral	0.13	damaging	4.02	23.60	deleterious	0.05	0.35	0.42	neutral	0.86	disease	0.74	disease	0.74	disease	5	0.91	neutral	0.24	neutral	2	deleterious	0.72	deleterious	-1.69	low_impact	0.17	medium_impact	2.37	high_impact	0.07	0.8	58.81	10.42	0.49	N	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4121	4121	G	C	MI.12453	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	815	272	W	S	tGa/tCa	7.34	1	0	probably_damaging	0.96	neutral	0.53	neutral	2.68	neutral	-2.98	deleterious	-12.58	high_impact	4.07	0.71	neutral	0.13	damaging	4.14	23.80	deleterious	0.06	0.35	0.27	neutral	0.88	disease	0.72	disease	0.74	disease	5	0.95	neutral	0.29	neutral	2	deleterious	0.73	deleterious	-2.05	low_impact	0.3	medium_impact	2.37	high_impact	0.05	0.8	58.81	10.42	0.51	N	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4121	4121	G	T	MI.12454	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	815	272	W	L	tGa/tTa	7.34	1	0	possibly_damaging	0.48	neutral	1	neutral	2.89	neutral	-0.75	deleterious	-11.69	medium_impact	2.73	0.69	neutral	0.09	damaging	4.34	24.00	deleterious	0.09	0.4	0.15	neutral	0.85	disease	0.68	disease	0.66	disease	3	0.48	neutral	0.76	deleterious	0	NA	0.43	deleterious	-0.72	medium_impact	1.96	high_impact	1.2	medium_impact	0.06	0.8	58.81	10.42	0.45	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4122	4122	A	C	MI.12455	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	816	272	W	C	tgA/tgC	7.11	1	0	probably_damaging	0.98	neutral	0.17	neutral	2.65	deleterious	-4.32	deleterious	-11.69	high_impact	3.72	0.7	neutral	0.08	damaging	4.11	23.80	deleterious	0.05	0.35	0.59	disease	0.87	disease	0.74	disease	0.77	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-2.34	low_impact	-0.11	medium_impact	2.06	high_impact	0.09	0.8	58.81	10.42	0.58	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4122	4122	A	T	MI.12456	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	816	272	W	C	tgA/tgT	7.11	1	0	probably_damaging	0.98	neutral	0.17	neutral	2.65	deleterious	-4.32	deleterious	-11.69	high_impact	3.72	0.7	neutral	0.08	damaging	4.23	23.90	deleterious	0.05	0.35	0.59	disease	0.87	disease	0.74	disease	0.77	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-2.34	low_impact	-0.11	medium_impact	2.06	high_impact	0.09	0.8	58.81	10.42	0.59	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4123	4123	A	T	MI.12457	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	817	273	I	F	Att/Ttt	0.45	0.1	0	possibly_damaging	0.75	neutral	0.72	neutral	2.47	deleterious	-3.33	deleterious	-3.27	medium_impact	2.15	0.7	neutral	0.36	neutral	3.97	23.60	deleterious	0.12	0.4	0.25	neutral	0.78	disease	0.47	neutral	0.63	disease	3	0.7	neutral	0.49	deleterious	0	NA	0.60	deleterious	-1.2	low_impact	0.51	medium_impact	0.69	medium_impact	0.68	0.85	17.3	12.04	0.33	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	A4123T	LHON	+	-	Reported	1	.	P	P	neutral
chrM	4123	4123	A	C	MI.12458	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	817	273	I	L	Att/Ctt	0.45	0.1	0	benign	0.17	neutral	0.85	neutral	2.61	neutral	-1.11	neutral	-1.59	medium_impact	2	0.7	neutral	0.41	neutral	3.90	23.50	deleterious	0.25	0.45	0.17	neutral	0.7	disease	0.5	neutral	0.53	disease	1	0.08	neutral	0.84	deleterious	-3	neutral	0.20	neutral	-0.1	medium_impact	0.7	medium_impact	0.56	medium_impact	0.56	0.8	17.3	12.04	0.31	N	0.54	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4123	4123	A	G	MI.12459	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	817	273	I	V	Att/Gtt	0.45	0.1	0	benign	0.01	neutral	0.73	neutral	2.9	neutral	0.36	neutral	0.26	neutral_impact	-0.17	0.81	neutral	0.96	neutral	0.43	6.87	deleterious	0.5	0.6	0.15	neutral	0.04	neutral	0.2	neutral	0.24	neutral	5	0.24	neutral	0.86	deleterious	-6	neutral	0.08	neutral	1.12	medium_impact	0.52	medium_impact	-1.34	low_impact	0.53	0.8	17.3	12.04	0.39	N	0.04	polymorphism	1	0.01	rs200764459	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9111	9111	T	G	MI.1246	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	585	195	I	M	atT/atG	5.68	0.9	0	possibly_damaging	0.63	deleterious	0.03	neutral	4.09	neutral	-1.88	neutral	-1.66	low_impact	1.68	0.86	neutral	0.43	neutral	3.12	22.60	deleterious	0.34	0.65	NA	NA	0.35	neutral	0.35	neutral	0.18	neutral	6	0.97	neutral	0.2	neutral	1	deleterious	0.40	neutral	-0.98	medium_impact	-0.56	medium_impact	0.34	medium_impact	0.68	0.9	20.35	25.84	0.49	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4124	4124	T	C	MI.12460	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	818	273	I	T	aTt/aCt	-0.24	0.06	0	benign	0.03	neutral	0.42	neutral	2.52	neutral	-2.12	deleterious	-2.59	medium_impact	2.19	0.73	neutral	0.67	neutral	2.46	19.21	deleterious	0.08	0.35	0.29	neutral	0.53	disease	0.48	neutral	0.48	neutral	0	0.56	neutral	0.7	deleterious	-3	neutral	0.15	neutral	0.67	medium_impact	0.2	medium_impact	0.72	medium_impact	0.39	0.8	17.3	12.04	0.43	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	COSM1155629	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4124	4124	T	A	MI.12461	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	818	273	I	N	aTt/aAt	-0.24	0.06	0	benign	0.04	neutral	0.27	neutral	2.44	deleterious	-4.57	deleterious	-5.04	medium_impact	3.45	0.72	neutral	0.43	neutral	4.70	24.60	deleterious	0.13	0.4	0.59	disease	0.9	disease	0.55	disease	0.76	disease	5	0.71	neutral	0.62	deleterious	-3	neutral	0.28	neutral	0.55	medium_impact	0.03	medium_impact	1.82	medium_impact	0.41	0.8	17.3	12.04	0.37	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4124	4124	T	G	MI.12462	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	818	273	I	S	aTt/aGt	-0.24	0.06	0	possibly_damaging	0.48	neutral	0.57	neutral	2.46	deleterious	-3.53	deleterious	-4.09	medium_impact	2.38	0.69	neutral	0.42	neutral	4.49	24.30	deleterious	0.05	0.35	0.4	neutral	0.81	disease	0.54	disease	0.74	disease	5	0.44	neutral	0.55	deleterious	0	NA	0.42	neutral	-0.72	medium_impact	0.34	medium_impact	0.89	medium_impact	0.34	0.8	17.3	12.04	0.28	N	0.94	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4125	4125	T	A	MI.12463	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	819	273	I	M	atT/atA	4.58	0.68	0	possibly_damaging	0.87	neutral	0.27	neutral	2.49	neutral	-2.63	neutral	-1.9	medium_impact	2.52	0.69	neutral	0.38	neutral	3.76	23.30	deleterious	0.22	0.45	0.33	neutral	0.63	disease	0.45	neutral	0.52	disease	0	0.9	neutral	0.2	neutral	0	NA	0.59	deleterious	-1.53	low_impact	0.03	medium_impact	1.01	medium_impact	0.61	0.8	17.3	12.04	0.48	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4125	4125	T	G	MI.12464	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	819	273	I	M	atT/atG	4.58	0.68	0	possibly_damaging	0.87	neutral	0.27	neutral	2.49	neutral	-2.63	neutral	-1.9	medium_impact	2.52	0.69	neutral	0.38	neutral	3.58	23.20	deleterious	0.22	0.45	0.33	neutral	0.63	disease	0.45	neutral	0.52	disease	0	0.9	neutral	0.2	neutral	0	NA	0.59	deleterious	-1.53	low_impact	0.03	medium_impact	1.01	medium_impact	0.61	0.8	17.3	12.04	0.47	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4126	4126	C	G	MI.12465	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	820	274	R	G	Cga/Gga	-9.43	0	0	possibly_damaging	0.74	neutral	0.35	neutral	2.12	deleterious	-4.86	deleterious	-6.29	high_impact	4.75	0.43	damaging	0.07	damaging	4.32	24.00	deleterious	0.03	0.35	0.53	disease	0.83	disease	0.74	disease	0.75	disease	5	0.78	neutral	0.31	neutral	1	deleterious	0.65	deleterious	-1.18	low_impact	0.12	medium_impact	2.96	high_impact	0.19	0.8	60.06	10.36	0.53	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4126	4126	C	T	MI.12466	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	820	274	R	W	Cga/Tga	-9.43	0	0	probably_damaging	0.99	neutral	0.26	neutral	2.09	deleterious	-7.39	deleterious	-7.19	high_impact	4.21	0.48	damaging	0.04	damaging	5.27	25.70	deleterious	0.05	0.35	0.87	disease	0.91	disease	0.75	disease	0.84	disease	7	0.99	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-2.62	low_impact	0.02	medium_impact	2.49	high_impact	0.64	0.8	60.06	10.36	0.36	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4127	4127	G	A	MI.12467	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	821	274	R	Q	cGa/cAa	4.35	0.99	0	probably_damaging	0.91	neutral	0.28	neutral	2.17	deleterious	-3.45	deleterious	-3.59	high_impact	4.41	0.34	damaging	0.04	damaging	4.63	24.50	deleterious	0.12	0.4	0.37	neutral	0.82	disease	0.76	disease	0.75	disease	5	0.93	neutral	0.19	neutral	2	deleterious	0.73	deleterious	-1.69	low_impact	0.05	medium_impact	2.66	high_impact	0.85	0.9	60.06	10.36	0.76	P	1.00	polymorphism	0.96	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4127	4127	G	T	MI.12468	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	821	274	R	L	cGa/cTa	4.35	0.99	0	possibly_damaging	0.88	neutral	0.87	neutral	2.13	deleterious	-4.46	deleterious	-6.29	high_impact	4.75	0.45	damaging	0.04	damaging	4.42	24.20	deleterious	0.03	0.35	0.5	neutral	0.93	disease	0.73	disease	0.82	disease	6	0.86	neutral	0.5	deleterious	1	deleterious	0.75	deleterious	-1.56	low_impact	0.74	medium_impact	2.96	high_impact	0.05	0.8	60.06	10.36	0.66	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4127	4127	G	C	MI.12469	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	821	274	R	P	cGa/cCa	4.35	0.99	0	probably_damaging	0.96	neutral	0.23	neutral	2.11	deleterious	-5.41	deleterious	-6.27	high_impact	4.75	0.49	damaging	0.05	damaging	4.31	24.00	deleterious	0.02	0.35	0.62	disease	0.87	disease	0.83	disease	0.8	disease	6	0.97	neutral	0.14	neutral	2	deleterious	0.84	deleterious	-2.05	low_impact	-0.02	medium_impact	2.96	high_impact	0.13	0.8	60.06	10.36	0.7	P	1.00	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9111	9111	T	A	MI.1247	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	585	195	I	M	atT/atA	5.68	0.9	0	possibly_damaging	0.63	deleterious	0.03	neutral	4.09	neutral	-1.88	neutral	-1.66	low_impact	1.68	0.86	neutral	0.43	neutral	3.44	23.00	deleterious	0.34	0.65	NA	NA	0.35	neutral	0.35	neutral	0.18	neutral	6	0.97	neutral	0.2	neutral	1	deleterious	0.40	neutral	-0.98	medium_impact	-0.56	medium_impact	0.34	medium_impact	0.68	0.9	20.35	25.84	0.49	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4129	4129	A	G	MI.12470	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	823	275	T	A	Aca/Gca	-0.24	0.65	0.01	benign	0.01	neutral	0.57	neutral	3	neutral	1.44	neutral	2.99	neutral_impact	-2.74	0.65	neutral	0.82	neutral	-1.04	0.01	neutral	0.17	0.45	0.15	neutral	0.05	neutral	0.15	neutral	0.23	neutral	5	0.42	neutral	0.78	deleterious	-6	neutral	0.12	neutral	1.12	medium_impact	0.34	medium_impact	-3.58	low_impact	0.35	0.8	17.61	21.08	0.35	N	0.00	polymorphism	1	0.01	rs201832206	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4129	4129	A	C	MI.12471	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	823	275	T	P	Aca/Cca	-0.24	0.65	0.01	possibly_damaging	0.65	neutral	0.24	neutral	2.74	neutral	-2.43	neutral	-1.23	neutral_impact	0.76	0.56	damaging	0.46	neutral	1.87	15.43	deleterious	0.04	0.35	0.38	neutral	0.86	disease	0.61	disease	0.78	disease	6	0.79	neutral	0.3	neutral	-3	neutral	0.64	deleterious	-1	low_impact	-0.01	medium_impact	-0.53	medium_impact	0.23	0.8	17.61	21.08	0.34	N	0.30	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4129	4129	A	T	MI.12472	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	823	275	T	S	Aca/Tca	-0.24	0.65	0.01	benign	0.03	neutral	0.47	neutral	2.85	neutral	0.12	neutral	0.56	neutral_impact	-0.34	0.68	neutral	0.79	neutral	1.48	13.22	neutral	0.25	0.45	0.11	neutral	0.45	neutral	0.29	neutral	0.43	neutral	1	0.5	neutral	0.72	deleterious	-6	neutral	0.18	neutral	0.67	medium_impact	0.25	medium_impact	-1.49	low_impact	0.68	0.85	17.61	21.08	0.33	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4130	4130	C	A	MI.12473	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	824	275	T	K	aCa/aAa	5.04	1	0	benign	0.36	neutral	0.29	neutral	2.79	neutral	-0.57	neutral	-1.23	low_impact	1.3	0.62	neutral	0.56	neutral	2.73	21.00	deleterious	0.08	0.35	0.18	neutral	0.72	disease	0.58	disease	0.67	disease	3	0.65	neutral	0.47	neutral	-6	neutral	0.40	neutral	-0.52	medium_impact	0.06	medium_impact	-0.05	medium_impact	0.46	0.8	17.61	21.08	0.59	P	0.42	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4130	4130	C	T	MI.12474	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	824	275	T	M	aCa/aTa	5.04	1	0	possibly_damaging	0.89	neutral	0.24	neutral	2.75	neutral	-1.85	neutral	-1.23	low_impact	1.1	0.63	neutral	0.54	neutral	3.74	23.30	deleterious	0.08	0.35	0.31	neutral	0.59	disease	0.49	neutral	0.49	neutral	0	0.92	neutral	0.18	neutral	-3	neutral	0.68	deleterious	-1.6	low_impact	-0.01	medium_impact	-0.23	medium_impact	0.57	0.8	17.61	21.08	0.61	P	0.43	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4132	4132	G	C	MI.12475	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	826	276	A	P	Gca/Cca	-1.39	0	0	benign	0.36	neutral	0.23	neutral	2.65	deleterious	-3.27	neutral	-1.88	medium_impact	2.7	0.53	damaging	0.41	neutral	2.13	17.07	deleterious	0.04	0.35	0.53	disease	0.84	disease	0.49	neutral	0.77	disease	5	0.73	neutral	0.44	neutral	-3	neutral	0.46	deleterious	-0.52	medium_impact	-0.02	medium_impact	1.17	medium_impact	0.53	0.8	24.53	38.18	0.4	N	0.79	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4132	4132	G	A	MI.12476	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	826	276	A	T	Gca/Aca	-1.39	0	0	benign	0	neutral	0.41	neutral	2.86	neutral	1.33	neutral	-0.08	neutral_impact	-0.34	0.69	neutral	0.8	neutral	2.37	18.62	deleterious	0.15	0.4	0.14	neutral	0.14	neutral	0.17	neutral	0.27	neutral	5	0.59	neutral	0.71	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.19	medium_impact	-1.49	low_impact	0.48	0.8	24.53	38.18	0.58	P	0.04	polymorphism	1	0.01	rs1057520201	Uncertain_significance	not_provided	364218	MedGen:CN517202	.	.	CPD	8.31	G4132A	NAION-associated	+	-	Reported	1	N	P	N,P	neutral
chrM	4132	4132	G	T	MI.12477	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	826	276	A	S	Gca/Tca	-1.39	0	0	benign	0	neutral	0.44	neutral	2.87	neutral	-0.1	neutral	2.49	neutral_impact	-1.47	0.66	neutral	0.81	neutral	-0.82	0.04	neutral	0.2	0.45	0.12	neutral	0.03	neutral	0.12	neutral	0.23	neutral	5	0.55	neutral	0.72	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.22	medium_impact	-2.47	low_impact	0.46	0.8	24.53	38.18	0.52	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4133	4133	C	G	MI.12478	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	827	276	A	G	gCa/gGa	2.52	0.99	0	benign	0.1	neutral	0.35	neutral	2.68	neutral	-2.73	neutral	-1	medium_impact	2	0.56	damaging	0.62	neutral	2.12	16.95	deleterious	0.16	0.45	0.24	neutral	0.54	disease	0.47	neutral	0.51	disease	0	0.6	neutral	0.63	deleterious	-3	neutral	0.20	neutral	0.15	medium_impact	0.12	medium_impact	0.56	medium_impact	0.62	0.8	24.53	38.18	0.57	P	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4133	4133	C	A	MI.12479	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	827	276	A	E	gCa/gAa	2.52	0.99	0	benign	0.15	neutral	0.26	neutral	2.7	neutral	-2.41	neutral	-1.02	medium_impact	2.35	0.6	neutral	0.59	neutral	2.80	21.40	deleterious	0.04	0.35	0.4	neutral	0.76	disease	0.63	disease	0.74	disease	5	0.7	neutral	0.56	deleterious	-3	neutral	0.32	neutral	-0.04	medium_impact	0.02	medium_impact	0.86	medium_impact	0.30	0.8	24.53	38.18	0.52	N	0.63	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9112	9112	C	G	MI.1248	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	586	196	L	V	Cta/Gta	-11.44	0	0	probably_damaging	0.99	neutral	0.21	neutral	4.43	neutral	-0.99	neutral	-2.21	low_impact	1.89	0.77	neutral	0.44	neutral	3.44	23.00	deleterious	0.32	0.65	NA	NA	0.49	neutral	0.53	disease	0.43	neutral	1	0.99	deleterious	0.11	neutral	-2	neutral	0.79	deleterious	-2.65	low_impact	-0.03	medium_impact	0.52	medium_impact	0.51	0.9	20.8	18.46	0.34	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4133	4133	C	T	MI.12480	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	827	276	A	V	gCa/gTa	2.52	0.99	0	benign	0.1	neutral	0.5	neutral	2.71	neutral	0.1	deleterious	-2.7	low_impact	1.42	0.56	damaging	0.76	neutral	2.62	20.30	deleterious	0.11	0.4	0.27	neutral	0.55	disease	0.5	neutral	0.5	disease	0	0.43	neutral	0.7	deleterious	-6	neutral	0.23	neutral	0.15	medium_impact	0.28	medium_impact	0.05	medium_impact	0.56	0.8	24.53	38.18	0.51	P	0.76	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4135	4135	T	C	MI.12481	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	829	277	Y	H	Tac/Cac	-14.26	0	0	probably_damaging	0.98	neutral	0.43	neutral	2.62	deleterious	-3.23	deleterious	-4.47	high_impact	4.04	0.56	damaging	0.32	neutral	3.73	23.30	deleterious	0.11	0.4	0.64	disease	0.83	disease	0.8	disease	0.81	disease	6	0.98	neutral	0.23	neutral	2	deleterious	0.79	deleterious	-2.34	low_impact	0.21	medium_impact	2.34	high_impact	0.13	0.8	60.06	10	0.38	N	1.00	polymorphism	1	0.18	rs876661355	Uncertain_significance	not_specified	236829	MedGen:CN169374	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4135	4135	T	A	MI.12482	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	829	277	Y	N	Tac/Aac	-14.26	0	0	probably_damaging	0.97	neutral	0.24	neutral	2.62	deleterious	-3.09	deleterious	-8.06	high_impact	3.7	0.69	neutral	0.4	neutral	4.19	23.90	deleterious	0.09	0.35	0.62	disease	0.89	disease	0.72	disease	0.78	disease	6	0.98	neutral	0.14	neutral	2	deleterious	0.80	deleterious	-2.17	low_impact	-0.01	medium_impact	2.04	high_impact	0.10	0.8	60.06	10	0.41	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4135	4135	T	G	MI.12483	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	829	277	Y	D	Tac/Gac	-14.26	0	0	probably_damaging	0.98	neutral	0.23	neutral	2.61	deleterious	-3.71	deleterious	-8.95	high_impact	4.04	0.71	neutral	0.36	neutral	4.16	23.80	deleterious	0.05	0.35	0.73	disease	0.9	disease	0.79	disease	0.82	disease	6	0.98	deleterious	0.13	neutral	2	deleterious	0.82	deleterious	-2.34	low_impact	-0.02	medium_impact	2.34	high_impact	0.09	0.8	60.06	10	0.48	N	1.00	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4136	4136	A	T	MI.12484	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	830	277	Y	F	tAc/tTc	7.34	1	0.01	possibly_damaging	0.74	neutral	0.78	neutral	2.71	neutral	-0.91	deleterious	-3.56	low_impact	1.59	0.65	neutral	0.45	neutral	3.45	23.00	deleterious	0.21	0.45	0.2	neutral	0.69	disease	0.51	disease	0.48	neutral	0	0.69	neutral	0.52	deleterious	-3	neutral	0.62	deleterious	-1.18	low_impact	0.58	medium_impact	0.2	medium_impact	0.33	0.8	60.06	10	0.55	P	0.80	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4136	4136	A	G	MI.12485	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	830	277	Y	C	tAc/tGc	7.34	1	0.01	probably_damaging	0.98	neutral	0.14	neutral	2.61	deleterious	-3.59	deleterious	-8.05	high_impact	4.04	0.83	neutral	0.37	neutral	3.57	23.20	deleterious	0.05	0.35	0.64	disease	0.89	disease	0.74	disease	0.79	disease	6	0.99	deleterious	0.08	neutral	2	deleterious	0.76	deleterious	-2.34	low_impact	-0.17	medium_impact	2.34	high_impact	0.03	0.8	60.06	10	0.71	P	1.00	disease_causing_automatic	0	0.15	rs199476121	Pathogenic	Leber's_optic_atrophy	24766	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	0.15	A4136G	LHON	+	-	Possibly synergistic	10	P	N	P,N	damaging
chrM	4136	4136	A	C	MI.12486	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	830	277	Y	S	tAc/tCc	7.34	1	0.01	probably_damaging	0.94	neutral	0.4	neutral	2.65	neutral	-2.12	deleterious	-8.05	high_impact	3.7	0.7	neutral	0.5	neutral	3.74	23.30	deleterious	0.06	0.35	0.45	neutral	0.85	disease	0.71	disease	0.76	disease	5	0.94	neutral	0.23	neutral	2	deleterious	0.77	deleterious	-1.87	low_impact	0.18	medium_impact	2.04	high_impact	0.19	0.8	60.06	10	0.66	P	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4138	4138	C	A	MI.12487	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	832	278	P	T	Ccc/Acc	-0.93	0.02	0	probably_damaging	1	neutral	0.39	neutral	1.19	deleterious	-6.45	deleterious	-7.18	high_impact	4.42	0.55	damaging	0.07	damaging	3.95	23.60	deleterious	0.05	0.35	0.53	disease	0.83	disease	0.69	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.17	medium_impact	2.67	high_impact	0.41	0.8	60.06	10.39	0.37	N	0.91	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4138	4138	C	G	MI.12488	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	832	278	P	A	Ccc/Gcc	-0.93	0.02	0	probably_damaging	1	neutral	0.51	neutral	1.22	deleterious	-5.75	deleterious	-7.18	high_impact	4.07	0.58	damaging	0.1	damaging	3.20	22.70	deleterious	0.06	0.35	0.27	neutral	0.76	disease	0.69	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	0.29	medium_impact	2.37	high_impact	0.48	0.8	60.06	10.39	0.32	N	0.78	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4138	4138	C	T	MI.12489	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	832	278	P	S	Ccc/Tcc	-0.93	0.02	0	probably_damaging	1	neutral	0.4	neutral	1.21	deleterious	-6.02	deleterious	-7.18	high_impact	3.79	0.58	damaging	0.1	damaging	3.99	23.60	deleterious	0.05	0.35	0.48	neutral	0.83	disease	0.69	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.18	medium_impact	2.12	high_impact	0.15	0.8	60.06	10.39	0.26	N	0.74	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9112	9112	C	A	MI.1249	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	586	196	L	M	Cta/Ata	-11.44	0	0	probably_damaging	1	neutral	0.22	neutral	4.32	neutral	-2.16	neutral	-1.64	medium_impact	2.07	0.74	neutral	0.18	damaging	3.79	23.40	deleterious	0.26	0.65	NA	NA	0.37	neutral	0.51	disease	0.25	neutral	5	1	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.02	medium_impact	0.68	medium_impact	0.56	0.9	20.8	18.46	0.35	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4139	4139	C	G	MI.12490	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	833	278	P	R	cCc/cGc	7.11	1	0	probably_damaging	1	neutral	0.35	neutral	1.18	deleterious	-6.98	deleterious	-8.08	high_impact	4.76	0.6	neutral	0.06	damaging	3.79	23.40	deleterious	0.03	0.35	0.69	disease	0.91	disease	0.8	disease	0.82	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.12	medium_impact	2.97	high_impact	0.25	0.8	60.06	10.39	0.71	P	0.71	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4139	4139	C	T	MI.12491	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	833	278	P	L	cCc/cTc	7.11	1	0	probably_damaging	1	neutral	0.65	neutral	1.19	deleterious	-6.82	deleterious	-8.97	high_impact	4.42	0.61	neutral	0.05	damaging	4.56	24.40	deleterious	0.03	0.35	0.55	disease	0.9	disease	0.69	disease	0.74	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.43	medium_impact	2.67	high_impact	0.43	0.8	60.06	10.39	0.53	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4139	4139	C	A	MI.12492	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	833	278	P	H	cCc/cAc	7.11	1	0	probably_damaging	1	neutral	0.54	neutral	1.17	deleterious	-8.08	deleterious	-8.08	high_impact	4.42	0.58	damaging	0.05	damaging	4.17	23.80	deleterious	0.03	0.35	0.81	disease	0.88	disease	0.79	disease	0.83	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.31	medium_impact	2.67	high_impact	0.19	0.8	60.06	10.39	0.62	P	0.69	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4141	4141	C	G	MI.12493	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	835	279	R	G	Cga/Gga	-4.38	0	0	probably_damaging	0.91	neutral	0.33	neutral	1.63	deleterious	-6.87	deleterious	-6.28	high_impact	4.76	0.62	neutral	0.08	damaging	4.36	24.10	deleterious	0.02	0.35	0.76	disease	0.82	disease	0.76	disease	0.77	disease	5	0.92	neutral	0.21	neutral	2	deleterious	0.78	deleterious	-1.69	low_impact	0.1	medium_impact	2.97	high_impact	0.07	0.8	59.43	10.54	0.59	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4141	4141	C	T	MI.12494	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	835	279	R	W	Cga/Tga	-4.38	0	0	probably_damaging	0.99	neutral	0.19	neutral	1.6	deleterious	-9.36	deleterious	-7.18	high_impact	4.76	0.72	neutral	0.08	damaging	5.35	25.90	deleterious	0.03	0.35	0.94	disease	0.91	disease	0.79	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-2.62	low_impact	-0.08	medium_impact	2.97	high_impact	0.33	0.8	59.43	10.54	0.59	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4142	4142	G	C	MI.12495	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	836	279	R	P	cGa/cCa	5.5	1	0	benign	0.12	neutral	0.2	neutral	1.61	deleterious	-7.19	deleterious	-6.28	high_impact	4.42	0.66	neutral	0.07	damaging	4.46	24.20	deleterious	0.02	0.35	0.81	disease	0.87	disease	0.83	disease	0.82	disease	6	0.77	neutral	0.54	deleterious	-2	neutral	0.38	neutral	0.06	medium_impact	-0.06	medium_impact	2.67	high_impact	0.07	0.8	59.43	10.54	0.61	P	1.00	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4142	4142	G	T	MI.12496	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	836	279	R	L	cGa/cTa	5.5	1	0	probably_damaging	0.91	neutral	0.65	neutral	1.63	deleterious	-6.26	deleterious	-6.28	high_impact	4.42	0.59	damaging	0.06	damaging	4.53	24.30	deleterious	0.02	0.35	0.73	disease	0.93	disease	0.76	disease	0.79	disease	6	0.89	neutral	0.37	neutral	2	deleterious	0.80	deleterious	-1.69	low_impact	0.43	medium_impact	2.67	high_impact	0.02	0.8	59.43	10.54	0.62	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4142	4142	G	A	MI.12497	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	836	279	R	Q	cGa/cAa	5.5	1	0	probably_damaging	0.93	neutral	0.29	neutral	1.65	deleterious	-5.34	deleterious	-3.59	high_impact	4.21	0.6	damaging	0.06	damaging	4.64	24.50	deleterious	0.04	0.35	0.56	disease	0.82	disease	0.74	disease	0.75	disease	5	0.94	neutral	0.18	neutral	2	deleterious	0.79	deleterious	-1.81	low_impact	0.06	medium_impact	2.49	high_impact	0.63	0.8	59.43	10.54	0.74	P	1.00	polymorphism	0.96	0.40	.	.	.	.	.	.	.	.	.	G4142A	Developmental delay, seizure, hypotonia	-	+	Reported	1	.	P	P	damaging
chrM	4144	4144	T	A	MI.12498	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	838	280	F	I	Ttc/Atc	0.45	0.97	0	benign	0.03	neutral	0.39	neutral	2.74	neutral	-1.09	deleterious	-5.36	medium_impact	2.42	0.74	neutral	0.61	neutral	2.65	20.50	deleterious	0.1	0.4	0.2	neutral	0.78	disease	0.34	neutral	0.5	disease	0	0.59	neutral	0.68	deleterious	-3	neutral	0.20	neutral	0.67	medium_impact	0.17	medium_impact	0.93	medium_impact	0.55	0.8	55.66	10.13	0.48	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4144	4144	T	C	MI.12499	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	838	280	F	L	Ttc/Ctc	0.45	0.97	0	benign	0.02	neutral	0.65	neutral	2.78	neutral	0.14	deleterious	-5.35	medium_impact	2.23	0.66	neutral	0.67	neutral	2.27	17.99	deleterious	0.13	0.4	0.14	neutral	0.78	disease	0.33	neutral	0.5	neutral	0	0.32	neutral	0.82	deleterious	-3	neutral	0.18	neutral	0.84	medium_impact	0.43	medium_impact	0.76	medium_impact	0.61	0.8	55.66	10.13	0.38	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8584	8584	G	A	MI.125	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	58	20	A	T	Gca/Aca	-5.89	0	0.17	benign	0.02	neutral	0.39	neutral	4.64	neutral	-0.81	neutral	-0.4	neutral_impact	0.06	0.99	neutral	0.95	neutral	0.81	9.54	deleterious	0.45	0.65	0.44	neutral	0.23	neutral	0.29	neutral	0.43	neutral	1	0.59	neutral	0.69	deleterious	-6	neutral	0.16	neutral	0.85	medium_impact	0.18	medium_impact	-1.05	low_impact	0.49	0.9	24.78	23.03	0.46	N	0.01	polymorphism	1	0.01	rs3135028	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9113	9113	T	C	MI.1250	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	587	196	L	P	cTa/cCa	-1.49	0	0	probably_damaging	1	deleterious	0.04	neutral	4.3	deleterious	-3.61	deleterious	-5.89	high_impact	3.6	0.56	damaging	0.16	damaging	3.95	23.60	deleterious	0.15	0.65	NA	NA	0.79	disease	0.72	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-0.49	medium_impact	1.99	medium_impact	0.54	0.9	20.8	18.46	0.28	N	1.00	disease_causing	0.87	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4144	4144	T	G	MI.12500	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	838	280	F	V	Ttc/Gtc	0.45	0.97	0	benign	0.19	neutral	0.5	neutral	2.78	neutral	-0.74	deleterious	-6.25	medium_impact	2.4	0.63	neutral	0.49	neutral	2.38	18.71	deleterious	0.08	0.35	0.18	neutral	0.86	disease	0.61	disease	0.71	disease	4	0.4	neutral	0.66	deleterious	-3	neutral	0.24	neutral	-0.16	medium_impact	0.28	medium_impact	0.91	medium_impact	0.43	0.8	55.66	10.13	0.43	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4145	4145	T	C	MI.12501	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	839	280	F	S	tTc/tCc	5.73	1	0	possibly_damaging	0.75	neutral	0.4	neutral	2.67	neutral	-2.67	deleterious	-7.16	high_impact	3.58	0.71	neutral	0.63	neutral	2.74	21.10	deleterious	0.04	0.35	0.34	neutral	0.82	disease	0.62	disease	0.69	disease	4	0.76	neutral	0.33	neutral	1	deleterious	0.63	deleterious	-1.2	low_impact	0.18	medium_impact	1.94	medium_impact	0.18	0.8	55.66	10.13	0.6	P	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4145	4145	T	G	MI.12502	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	839	280	F	C	tTc/tGc	5.73	1	0	probably_damaging	0.94	neutral	0.18	neutral	2.63	deleterious	-3.76	deleterious	-7.15	high_impact	3.92	0.7	neutral	0.48	neutral	4.03	23.60	deleterious	0.04	0.35	0.54	disease	0.84	disease	0.63	disease	0.71	disease	4	0.96	neutral	0.12	neutral	2	deleterious	0.74	deleterious	-1.87	low_impact	-0.09	medium_impact	2.24	high_impact	0.18	0.8	55.66	10.13	0.65	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4145	4145	T	A	MI.12503	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	839	280	F	Y	tTc/tAc	5.73	1	0	possibly_damaging	0.75	neutral	1	neutral	2.75	neutral	-0.89	deleterious	-2.68	medium_impact	1.94	0.7	neutral	0.46	neutral	2.79	21.30	deleterious	0.13	0.4	0.21	neutral	0.56	disease	0.28	neutral	0.41	neutral	2	0.75	neutral	0.63	deleterious	0	NA	0.47	deleterious	-1.2	low_impact	1.96	high_impact	0.51	medium_impact	0.66	0.8	55.66	10.13	0.53	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4146	4146	C	G	MI.12504	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	840	280	F	L	ttC/ttG	7.34	1	0	benign	0.02	neutral	0.65	neutral	2.78	neutral	0.14	deleterious	-5.35	medium_impact	2.23	0.66	neutral	0.67	neutral	2.55	19.78	deleterious	0.13	0.4	0.14	neutral	0.78	disease	0.33	neutral	0.5	neutral	0	0.32	neutral	0.82	deleterious	-3	neutral	0.18	neutral	0.84	medium_impact	0.43	medium_impact	0.76	medium_impact	0.61	0.8	55.66	10.13	0.52	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4146	4146	C	A	MI.12505	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	840	280	F	L	ttC/ttA	7.34	1	0	benign	0.02	neutral	0.65	neutral	2.78	neutral	0.14	deleterious	-5.35	medium_impact	2.23	0.66	neutral	0.67	neutral	2.83	21.50	deleterious	0.13	0.4	0.14	neutral	0.78	disease	0.33	neutral	0.5	neutral	0	0.32	neutral	0.82	deleterious	-3	neutral	0.18	neutral	0.84	medium_impact	0.43	medium_impact	0.76	medium_impact	0.61	0.8	55.66	10.13	0.52	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4147	4147	C	T	MI.12506	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	841	281	R	C	Cgc/Tgc	-3.46	0	0	benign	0.01	neutral	0.17	neutral	1.6	deleterious	-9.27	deleterious	-7.16	high_impact	4.75	0.55	damaging	0.18	damaging	3.17	22.70	deleterious	0.06	0.35	0.93	disease	0.83	disease	0.78	disease	0.85	disease	7	0.83	neutral	0.58	deleterious	-2	neutral	0.33	neutral	1.12	medium_impact	-0.11	medium_impact	2.96	high_impact	0.65	0.8	58.49	10.46	0.51	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4147	4147	C	A	MI.12507	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	841	281	R	S	Cgc/Agc	-3.46	0	0	possibly_damaging	0.65	neutral	0.43	neutral	1.64	deleterious	-6.12	deleterious	-5.37	high_impact	4.39	0.55	damaging	0.35	neutral	2.76	21.20	deleterious	0.03	0.35	0.65	disease	0.78	disease	0.73	disease	0.74	disease	5	0.66	neutral	0.39	neutral	1	deleterious	0.55	deleterious	-1	low_impact	0.21	medium_impact	2.65	high_impact	0.18	0.8	58.49	10.46	0.42	N	0.74	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4147	4147	C	G	MI.12508	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	841	281	R	G	Cgc/Ggc	-3.46	0	0	possibly_damaging	0.78	neutral	0.32	neutral	1.63	deleterious	-7.07	deleterious	-6.27	high_impact	4.39	0.59	damaging	0.35	neutral	2.47	19.28	deleterious	0.03	0.35	0.75	disease	0.75	disease	0.74	disease	0.75	disease	5	0.81	neutral	0.27	neutral	1	deleterious	0.58	deleterious	-1.27	low_impact	0.09	medium_impact	2.65	high_impact	0.17	0.8	58.49	10.46	0.42	N	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4148	4148	G	C	MI.12509	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	842	281	R	P	cGc/cCc	4.35	1	0	probably_damaging	0.94	neutral	0.21	neutral	1.61	deleterious	-7.52	deleterious	-6.27	high_impact	4.04	0.57	damaging	0.26	damaging	2.78	21.20	deleterious	0.02	0.35	0.81	disease	0.84	disease	0.84	disease	0.8	disease	6	0.96	neutral	0.14	neutral	2	deleterious	0.84	deleterious	-1.87	low_impact	-0.05	medium_impact	2.34	high_impact	0.13	0.8	58.49	10.46	0.6	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9113	9113	T	A	MI.1251	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	587	196	L	Q	cTa/cAa	-1.49	0	0	probably_damaging	1	neutral	0.48	neutral	4.31	deleterious	-3.26	deleterious	-5.1	low_impact	1.73	0.57	damaging	0.15	damaging	4.07	23.70	deleterious	0.17	0.65	NA	NA	0.42	neutral	0.41	neutral	0.18	neutral	6	1	deleterious	0.24	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.27	medium_impact	0.39	medium_impact	0.54	0.9	20.8	18.46	0.3	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4148	4148	G	T	MI.12510	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	842	281	R	L	cGc/cTc	4.35	1	0	possibly_damaging	0.52	neutral	0.65	neutral	1.63	deleterious	-6.64	deleterious	-6.26	high_impact	4.39	0.56	damaging	0.3	neutral	2.57	19.89	deleterious	0.03	0.35	0.73	disease	0.9	disease	0.74	disease	0.77	disease	5	0.43	neutral	0.57	deleterious	1	deleterious	0.52	deleterious	-0.78	medium_impact	0.43	medium_impact	2.65	high_impact	0.10	0.8	58.49	10.46	0.59	P	1.00	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4148	4148	G	A	MI.12511	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	842	281	R	H	cGc/cAc	4.35	1	0	probably_damaging	0.96	neutral	0.52	neutral	1.62	deleterious	-6.4	deleterious	-4.48	high_impact	4.75	0.48	damaging	0.18	damaging	4.14	23.80	deleterious	0.06	0.35	0.74	disease	0.79	disease	0.77	disease	0.76	disease	5	0.95	neutral	0.28	neutral	2	deleterious	0.82	deleterious	-2.05	low_impact	0.29	medium_impact	2.96	high_impact	0.75	0.85	58.49	10.46	0.74	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4150	4150	T	A	MI.12512	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	844	282	Y	N	Tac/Aac	-8.97	0	0	probably_damaging	1	neutral	0.23	neutral	2.41	deleterious	-4.09	deleterious	-8.06	high_impact	4.64	0.66	neutral	0.33	neutral	4.19	23.80	deleterious	0.05	0.35	0.49	neutral	0.88	disease	0.73	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.02	medium_impact	2.86	high_impact	0.15	0.8	59.43	10.34	0.54	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4150	4150	T	C	MI.12513	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	844	282	Y	H	Tac/Cac	-8.97	0	0	probably_damaging	1	neutral	0.39	neutral	2.41	deleterious	-4.23	deleterious	-4.48	high_impact	4.64	0.63	neutral	0.26	damaging	3.75	23.30	deleterious	0.11	0.4	0.56	disease	0.82	disease	0.76	disease	0.77	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	0.17	medium_impact	2.86	high_impact	0.23	0.8	59.43	10.34	0.55	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4150	4150	T	G	MI.12514	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	844	282	Y	D	Tac/Gac	-8.97	0	0	probably_damaging	1	neutral	0.21	neutral	2.4	deleterious	-4.59	deleterious	-8.96	high_impact	4.1	0.68	neutral	0.3	neutral	4.12	23.80	deleterious	0.03	0.35	0.58	disease	0.89	disease	0.8	disease	0.79	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	-0.05	medium_impact	2.39	high_impact	0.13	0.8	59.43	10.34	0.48	N	1.00	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4151	4151	A	C	MI.12515	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	845	282	Y	S	tAc/tCc	7.34	1	0	probably_damaging	1	neutral	0.42	neutral	2.43	deleterious	-3.25	deleterious	-8.06	high_impact	4.1	0.64	neutral	0.39	neutral	3.85	23.40	deleterious	0.04	0.35	0.26	neutral	0.84	disease	0.73	disease	0.73	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.2	medium_impact	2.39	high_impact	0.22	0.8	59.43	10.34	0.62	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4151	4151	A	T	MI.12516	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	845	282	Y	F	tAc/tTc	7.34	1	0	probably_damaging	1	neutral	0.6	neutral	2.48	neutral	-2.39	deleterious	-3.59	medium_impact	2.71	0.62	neutral	0.29	neutral	3.59	23.20	deleterious	0.2	0.45	0.3	neutral	0.79	disease	0.66	disease	0.69	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.37	medium_impact	1.18	medium_impact	0.43	0.8	59.43	10.34	0.54	P	0.80	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4151	4151	A	G	MI.12517	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	845	282	Y	C	tAc/tGc	7.34	1	0	probably_damaging	1	neutral	0.14	neutral	2.4	deleterious	-4.87	deleterious	-8.07	high_impact	4.1	0.67	neutral	0.22	damaging	3.68	23.30	deleterious	0.03	0.35	0.57	disease	0.85	disease	0.77	disease	0.78	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.17	medium_impact	2.39	high_impact	0.08	0.8	59.43	10.34	0.67	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4153	4153	G	C	MI.12518	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	847	283	D	H	Gac/Cac	-3	0	0	probably_damaging	1	neutral	0.53	neutral	1.55	deleterious	-6.67	deleterious	-6.28	high_impact	4.74	0.62	neutral	0.25	damaging	3.77	23.40	deleterious	0.05	0.35	0.65	disease	0.85	disease	0.8	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.3	medium_impact	2.95	high_impact	0.41	0.8	58.81	10.84	0.65	P	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4153	4153	G	T	MI.12519	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	847	283	D	Y	Gac/Tac	-3	0	0	probably_damaging	1	neutral	1	neutral	1.54	deleterious	-7.42	deleterious	-8.07	high_impact	4.39	0.66	neutral	0.28	damaging	4.04	23.70	deleterious	0.03	0.35	0.77	disease	0.93	disease	0.76	disease	0.8	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.89	deleterious	-3.57	low_impact	1.96	high_impact	2.65	high_impact	0.13	0.8	58.81	10.84	0.44	N	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9113	9113	T	G	MI.1252	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	587	196	L	R	cTa/cGa	-1.49	0	0	probably_damaging	1	neutral	0.07	neutral	4.27	deleterious	-3.78	deleterious	-5.14	high_impact	3.6	0.52	damaging	0.13	damaging	4.18	23.80	deleterious	0.16	0.65	NA	NA	0.84	disease	0.73	disease	0.78	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.34	medium_impact	1.99	medium_impact	0.48	0.9	20.8	18.46	0.3	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4153	4153	G	A	MI.12520	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	847	283	D	N	Gac/Aac	-3	0	0	probably_damaging	1	neutral	0.3	neutral	1.59	deleterious	-5.04	deleterious	-4.48	medium_impact	3.35	0.64	neutral	0.34	neutral	4.41	24.10	deleterious	0.27	0.45	0.45	neutral	0.85	disease	0.65	disease	0.71	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	0.07	medium_impact	1.74	medium_impact	0.77	0.85	58.81	10.84	0.41	N	1.00	polymorphism	1	0.23	rs28566134	.	.	.	.	.	COSM1155631	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4154	4154	A	C	MI.12521	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	848	283	D	A	gAc/gCc	9.18	1	0	probably_damaging	1	neutral	0.5	neutral	1.58	deleterious	-5.36	deleterious	-7.18	high_impact	4.74	0.65	neutral	0.39	neutral	4.28	24.00	deleterious	0.05	0.35	0.46	neutral	0.84	disease	0.74	disease	0.75	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.28	medium_impact	2.95	high_impact	0.23	0.8	58.81	10.84	0.7	P	0.94	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4154	4154	A	T	MI.12522	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	848	283	D	V	gAc/gTc	9.18	1	0	probably_damaging	1	neutral	0.5	neutral	1.55	deleterious	-6.62	deleterious	-8.07	high_impact	4.74	0.6	damaging	0.33	neutral	4.46	24.20	deleterious	0.03	0.35	0.65	disease	0.91	disease	0.74	disease	0.78	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.86	deleterious	-3.57	low_impact	0.28	medium_impact	2.95	high_impact	0.09	0.8	58.81	10.84	0.69	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4154	4154	A	G	MI.12523	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	848	283	D	G	gAc/gGc	9.18	1	0	probably_damaging	1	neutral	0.33	neutral	1.57	deleterious	-5.53	deleterious	-6.28	high_impact	4.2	0.65	neutral	0.38	neutral	4.69	24.60	deleterious	0.05	0.35	0.57	disease	0.86	disease	0.75	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.1	medium_impact	2.48	high_impact	0.33	0.8	58.81	10.84	0.66	P	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4155	4155	C	G	MI.12524	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	849	283	D	E	gaC/gaG	8.49	1	0.01	probably_damaging	1	neutral	0.27	neutral	1.64	deleterious	-4.18	deleterious	-3.59	high_impact	4.39	0.66	neutral	0.35	neutral	4.03	23.60	deleterious	0.12	0.4	0.29	neutral	0.78	disease	0.73	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.03	medium_impact	2.65	high_impact	0.43	0.8	58.81	10.84	0.66	P	0.95	polymorphism	0.97	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4155	4155	C	A	MI.12525	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	849	283	D	E	gaC/gaA	8.49	1	0.01	probably_damaging	1	neutral	0.27	neutral	1.64	deleterious	-4.18	deleterious	-3.59	high_impact	4.39	0.66	neutral	0.35	neutral	4.34	24.00	deleterious	0.12	0.4	0.29	neutral	0.78	disease	0.73	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.03	medium_impact	2.65	high_impact	0.43	0.8	58.81	10.84	0.66	P	0.95	polymorphism	0.97	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4156	4156	C	A	MI.12526	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	850	284	Q	K	Caa/Aaa	-3.92	0	0	probably_damaging	1	neutral	0.35	neutral	2.64	neutral	-2.45	deleterious	-3.53	medium_impact	2.23	0.71	neutral	0.12	damaging	4.15	23.80	deleterious	0.15	0.4	0.22	neutral	0.63	disease	0.39	neutral	0.41	neutral	2	1	deleterious	0.18	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.12	medium_impact	0.76	medium_impact	0.31	0.8	59.12	10.3	0.27	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4156	4156	C	G	MI.12527	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	850	284	Q	E	Caa/Gaa	-3.92	0	0	probably_damaging	1	neutral	0.32	neutral	2.54	neutral	-2.77	deleterious	-2.64	high_impact	3.54	0.74	neutral	0.15	damaging	3.19	22.70	deleterious	0.16	0.45	0.28	neutral	0.81	disease	0.63	disease	0.68	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-3.57	low_impact	0.09	medium_impact	1.9	medium_impact	0.29	0.8	59.12	10.3	0.32	N	0.93	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4157	4157	A	T	MI.12528	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	851	284	Q	L	cAa/cTa	4.4	1	0	probably_damaging	1	neutral	0.67	neutral	2.53	deleterious	-4.2	deleterious	-6.2	medium_impact	2.55	0.7	neutral	0.1	damaging	3.95	23.60	deleterious	0.05	0.35	0.33	neutral	0.91	disease	0.59	disease	0.69	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.82	deleterious	-3.57	low_impact	0.45	medium_impact	1.04	medium_impact	0.07	0.8	59.12	10.3	0.39	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4157	4157	A	C	MI.12529	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	851	284	Q	P	cAa/cCa	4.4	1	0	probably_damaging	1	neutral	0.24	neutral	2.46	deleterious	-5.01	deleterious	-5.31	high_impact	4.44	0.72	neutral	0.13	damaging	3.46	23.00	deleterious	0.02	0.35	0.58	disease	0.92	disease	0.73	disease	0.8	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	-0.01	medium_impact	2.69	high_impact	0.17	0.8	59.12	10.3	0.65	P	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9115	9115	A	C	MI.1253	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	589	197	I	L	Att/Ctt	-8.2	0	0.01	benign	0.02	neutral	0.74	neutral	4.53	neutral	-0.18	neutral	-0.57	neutral_impact	-0.13	0.9	neutral	0.92	neutral	-0.48	0.25	neutral	0.17	0.65	NA	NA	0.18	neutral	0.22	neutral	0.22	neutral	6	0.22	neutral	0.86	deleterious	-6	neutral	0.13	neutral	0.85	medium_impact	0.55	medium_impact	-1.21	low_impact	0.28	0.9	24.78	14.04	0.37	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4157	4157	A	G	MI.12530	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	851	284	Q	R	cAa/cGa	4.4	1	0	probably_damaging	1	neutral	0.4	neutral	2.55	deleterious	-3	deleterious	-3.51	medium_impact	3.46	0.77	neutral	0.15	damaging	3.64	23.20	deleterious	0.1	0.4	0.27	neutral	0.9	disease	0.66	disease	0.74	disease	5	1	deleterious	0.2	neutral	1	deleterious	0.81	deleterious	-3.57	low_impact	0.18	medium_impact	1.83	medium_impact	0.21	0.8	59.12	10.3	0.51	N	0.95	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4158	4158	A	T	MI.12531	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	852	284	Q	H	caA/caT	8.55	1	0	probably_damaging	1	neutral	0.52	neutral	2.47	deleterious	-4.26	deleterious	-4.33	medium_impact	3.24	0.72	neutral	0.13	damaging	3.70	23.30	deleterious	0.13	0.4	0.53	disease	0.83	disease	0.57	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	0.29	medium_impact	1.64	medium_impact	0.43	0.8	59.12	10.3	0.55	P	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4158	4158	A	C	MI.12532	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	852	284	Q	H	caA/caC	8.55	1	0	probably_damaging	1	neutral	0.52	neutral	2.47	deleterious	-4.26	deleterious	-4.33	medium_impact	3.24	0.72	neutral	0.13	damaging	3.56	23.10	deleterious	0.13	0.4	0.53	disease	0.83	disease	0.57	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	0.29	medium_impact	1.64	medium_impact	0.43	0.8	59.12	10.3	0.55	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4159	4159	C	A	MI.12533	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	853	285	L	I	Ctc/Atc	-0.2	0.5	0	probably_damaging	1	neutral	0.38	neutral	2.1	neutral	-2.86	neutral	-1.79	medium_impact	3.11	0.56	damaging	0.08	damaging	4.38	24.10	deleterious	0.18	0.45	0.24	neutral	0.71	disease	0.69	disease	0.68	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.16	medium_impact	1.53	medium_impact	0.51	0.8	60.06	10.34	0.3	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4159	4159	C	T	MI.12534	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	853	285	L	F	Ctc/Ttc	-0.2	0.5	0	probably_damaging	1	neutral	0.8	neutral	2.04	deleterious	-3.65	deleterious	-3.58	medium_impact	2.66	0.48	damaging	0.06	damaging	4.08	23.70	deleterious	0.08	0.35	0.42	neutral	0.75	disease	0.73	disease	0.72	disease	4	1	deleterious	0.4	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.61	medium_impact	1.14	medium_impact	0.53	0.8	60.06	10.34	0.34	N	0.95	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4159	4159	C	G	MI.12535	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	853	285	L	V	Ctc/Gtc	-0.2	0.5	0	probably_damaging	1	neutral	0.47	neutral	2.1	neutral	-2.81	deleterious	-2.69	medium_impact	3.16	0.51	damaging	0.06	damaging	3.54	23.10	deleterious	0.14	0.4	0.28	neutral	0.67	disease	0.7	disease	0.68	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.25	medium_impact	1.57	medium_impact	0.48	0.8	60.06	10.34	0.33	N	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4160	4160	T	C	MI.12536	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	854	285	L	P	cTc/cCc	1.64	0.94	0	probably_damaging	1	neutral	0.26	neutral	1.96	deleterious	-6.68	deleterious	-6.27	high_impact	4.66	0.27	damaging	0.06	damaging	4.12	23.80	deleterious	0.01	0.35	0.72	disease	0.82	disease	0.8	disease	0.78	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.02	medium_impact	2.88	high_impact	0.31	0.8	60.06	10.34	0.89	P	1.00	disease_causing_automatic	0	0.36	rs199476119	Pathogenic	Leber's_optic_atrophy	24762	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	T4160C	LHON	+	-	Reported	10	P	P	P	damaging
chrM	4160	4160	T	A	MI.12537	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	854	285	L	H	cTc/cAc	1.64	0.94	0	probably_damaging	1	neutral	0.49	neutral	1.95	deleterious	-6.84	deleterious	-6.27	high_impact	4.66	0.47	damaging	0.05	damaging	4.42	24.20	deleterious	0.03	0.35	0.71	disease	0.84	disease	0.79	disease	0.78	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.27	medium_impact	2.88	high_impact	0.29	0.8	60.06	10.34	0.6	P	0.97	polymorphism	1	0.36	.	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4160	4160	T	G	MI.12538	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	854	285	L	R	cTc/cGc	1.64	0.94	0	probably_damaging	1	neutral	0.49	neutral	1.96	deleterious	-6.1	deleterious	-5.38	high_impact	4.66	0.36	damaging	0.05	damaging	4.38	24.10	deleterious	0.01	0.35	0.43	neutral	0.9	disease	0.8	disease	0.8	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.27	medium_impact	2.88	high_impact	0.16	0.8	60.06	10.34	0.68	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4162	4162	A	T	MI.12539	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	856	286	M	L	Ata/Tta	-7.8	0	0	probably_damaging	0.98	neutral	0.65	neutral	2.79	neutral	-0.05	deleterious	-2.68	medium_impact	3.08	0.77	neutral	0.14	damaging	3.38	23.00	deleterious	0.16	0.45	0.17	neutral	0.83	disease	0.59	disease	0.69	disease	4	0.98	deleterious	0.34	neutral	1	deleterious	0.75	deleterious	-2.34	low_impact	0.43	medium_impact	1.5	medium_impact	0.31	0.8	59.12	10.29	0.24	N	0.95	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9115	9115	A	G	MI.1254	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	589	197	I	V	Att/Gtt	-8.2	0	0.01	benign	0.01	neutral	1	neutral	4.48	neutral	-0.35	neutral	-0.23	neutral_impact	-0.16	0.87	neutral	0.96	neutral	-1.06	0.01	neutral	0.48	0.65	NA	NA	0.16	neutral	0.31	neutral	0.21	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.14	medium_impact	1.98	high_impact	-1.24	low_impact	0.28	0.9	24.78	14.04	0.28	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4162	4162	A	G	MI.12540	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	856	286	M	V	Ata/Gta	-7.8	0	0	probably_damaging	0.99	neutral	0.5	neutral	2.46	neutral	-2.05	deleterious	-3.58	medium_impact	2.97	0.54	damaging	0.09	damaging	2.81	21.40	deleterious	0.14	0.4	0.24	neutral	0.83	disease	0.68	disease	0.7	disease	4	0.99	deleterious	0.26	neutral	1	deleterious	0.77	deleterious	-2.62	low_impact	0.28	medium_impact	1.41	medium_impact	0.33	0.8	59.12	10.29	0.26	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4162	4162	A	C	MI.12541	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	856	286	M	L	Ata/Cta	-7.8	0	0	probably_damaging	0.98	neutral	0.65	neutral	2.79	neutral	-0.05	deleterious	-2.68	medium_impact	3.08	0.77	neutral	0.14	damaging	3.28	22.80	deleterious	0.16	0.45	0.17	neutral	0.83	disease	0.59	disease	0.69	disease	4	0.98	deleterious	0.34	neutral	1	deleterious	0.75	deleterious	-2.34	low_impact	0.43	medium_impact	1.5	medium_impact	0.31	0.8	59.12	10.29	0.23	N	0.95	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4163	4163	T	C	MI.12542	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	857	286	M	T	aTa/aCa	8.55	1	0	probably_damaging	1	neutral	0.39	neutral	2.37	deleterious	-3.81	deleterious	-5.37	high_impact	3.62	0.57	damaging	0.11	damaging	3.11	22.50	deleterious	0.04	0.35	0.27	neutral	0.88	disease	0.69	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.17	medium_impact	1.97	medium_impact	0.15	0.8	59.12	10.29	0.51	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	T4163C	LHON	+	-	Reported	1	.	P	P	damaging
chrM	4163	4163	T	A	MI.12543	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	857	286	M	K	aTa/aAa	8.55	1	0	probably_damaging	1	neutral	0.29	neutral	2.36	deleterious	-4.46	deleterious	-5.38	high_impact	4.33	0.63	neutral	0.09	damaging	4.10	23.70	deleterious	0.02	0.35	0.24	neutral	0.9	disease	0.74	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.06	medium_impact	2.59	high_impact	0.17	0.8	59.12	10.29	0.63	P	1.00	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4164	4164	A	T	MI.12544	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	858	286	M	I	atA/atT	4.63	1	0.09	probably_damaging	0.99	neutral	0.39	neutral	2.48	neutral	-1.85	deleterious	-3.57	medium_impact	3	0.61	neutral	0.09	damaging	3.60	23.20	deleterious	0.11	0.4	0.3	neutral	0.84	disease	0.62	disease	0.7	disease	4	0.99	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-2.62	low_impact	0.17	medium_impact	1.43	medium_impact	0.26	0.8	59.12	10.29	0.5	N	0.95	disease_causing	1	0.15	rs386420034	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4164	4164	A	C	MI.12545	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	858	286	M	I	atA/atC	4.63	1	0.09	probably_damaging	0.99	neutral	0.39	neutral	2.48	neutral	-1.85	deleterious	-3.57	medium_impact	3	0.61	neutral	0.09	damaging	3.56	23.10	deleterious	0.11	0.4	0.3	neutral	0.84	disease	0.62	disease	0.7	disease	4	0.99	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-2.62	low_impact	0.17	medium_impact	1.43	medium_impact	0.26	0.8	59.12	10.29	0.49	N	0.95	disease_causing	1	0.15	rs386420034	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4165	4165	C	T	MI.12546	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	859	287	H	Y	Cac/Tac	-0.43	0.07	0	benign	0.02	neutral	1	neutral	2.81	neutral	-0.53	deleterious	-5.09	low_impact	1.35	0.74	neutral	0.73	neutral	1.84	15.23	deleterious	0.19	0.45	0.27	neutral	0.52	disease	0.16	neutral	0.41	neutral	2	0.02	neutral	0.99	deleterious	-6	neutral	0.21	neutral	0.84	medium_impact	1.96	high_impact	-0.01	medium_impact	0.27	0.8	18.87	12.35	0.36	N	0.55	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4165	4165	C	A	MI.12547	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	859	287	H	N	Cac/Aac	-0.43	0.07	0	possibly_damaging	0.44	neutral	0.17	neutral	2.85	neutral	1.37	deleterious	-6.15	low_impact	1.76	0.69	neutral	0.34	neutral	2.18	17.38	deleterious	0.24	0.45	0.15	neutral	0.81	disease	0.26	neutral	0.49	neutral	0	0.8	neutral	0.37	neutral	-3	neutral	0.41	neutral	-0.65	medium_impact	-0.11	medium_impact	0.35	medium_impact	0.35	0.8	18.87	12.35	0.39	N	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4165	4165	C	G	MI.12548	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	859	287	H	D	Cac/Gac	-0.43	0.07	0	possibly_damaging	0.57	neutral	0.2	neutral	2.82	neutral	1.07	deleterious	-7.9	medium_impact	2.21	0.72	neutral	0.3	neutral	2.17	17.29	deleterious	0.06	0.35	0.17	neutral	0.83	disease	0.51	disease	0.7	disease	4	0.8	neutral	0.32	neutral	0	NA	0.43	neutral	-0.87	medium_impact	-0.06	medium_impact	0.74	medium_impact	0.33	0.8	18.87	12.35	0.38	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4166	4166	A	T	MI.12549	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	860	287	H	L	cAc/cTc	2.79	0.98	0	possibly_damaging	0.44	neutral	0.74	neutral	2.8	neutral	-0.59	deleterious	-9.58	medium_impact	2.6	0.68	neutral	0.36	neutral	1.95	15.92	deleterious	0.06	0.35	0.29	neutral	0.88	disease	0.45	neutral	0.73	disease	5	0.33	neutral	0.65	deleterious	0	NA	0.39	neutral	-0.65	medium_impact	0.53	medium_impact	1.08	medium_impact	0.21	0.8	18.87	12.35	0.45	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9115	9115	A	T	MI.1255	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	589	197	I	F	Att/Ttt	-8.2	0	0.01	benign	0.16	neutral	0.9	neutral	4.31	neutral	-1.64	neutral	-0.89	neutral_impact	-0.2	0.88	neutral	0.95	neutral	-0.62	0.11	neutral	0.3	0.65	NA	NA	0.25	neutral	0.25	neutral	0.17	neutral	7	0.07	neutral	0.87	deleterious	-6	neutral	0.31	neutral	-0.07	medium_impact	0.83	medium_impact	-1.27	low_impact	0.37	0.9	24.78	14.04	0.3	N	0.03	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4166	4166	A	G	MI.12550	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	860	287	H	R	cAc/cGc	2.79	0.98	0	possibly_damaging	0.57	neutral	0.48	neutral	2.86	neutral	1.93	deleterious	-7.01	low_impact	1.86	0.67	neutral	0.28	damaging	1.14	11.41	neutral	0.12	0.4	0.14	neutral	0.82	disease	0.22	neutral	0.48	neutral	0	0.57	neutral	0.46	neutral	-3	neutral	0.39	neutral	-0.87	medium_impact	0.26	medium_impact	0.44	medium_impact	0.30	0.8	18.87	12.35	0.42	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4166	4166	A	C	MI.12551	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	860	287	H	P	cAc/cCc	2.79	0.98	0	possibly_damaging	0.89	neutral	0.13	neutral	2.77	neutral	-1.16	deleterious	-8.76	medium_impact	3.45	0.69	neutral	0.27	damaging	1.60	13.84	neutral	0.05	0.35	0.37	neutral	0.91	disease	0.62	disease	0.73	disease	5	0.95	neutral	0.12	neutral	0	NA	0.72	deleterious	-1.6	low_impact	-0.19	medium_impact	1.82	medium_impact	0.15	0.8	18.87	12.35	0.56	P	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4167	4167	C	G	MI.12552	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	861	287	H	Q	caC/caG	6.71	0.99	0	benign	0.06	neutral	0.24	neutral	2.83	neutral	0.83	deleterious	-6.98	medium_impact	2.9	0.72	neutral	0.42	neutral	1.92	15.69	deleterious	0.17	0.45	0.17	neutral	0.75	disease	0.25	neutral	0.53	disease	1	0.74	neutral	0.59	deleterious	-3	neutral	0.21	neutral	0.37	medium_impact	-0.01	medium_impact	1.34	medium_impact	0.34	0.8	18.87	12.35	0.58	P	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4167	4167	C	A	MI.12553	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	861	287	H	Q	caC/caA	6.71	0.99	0	benign	0.06	neutral	0.24	neutral	2.83	neutral	0.83	deleterious	-6.98	medium_impact	2.9	0.72	neutral	0.42	neutral	2.25	17.85	deleterious	0.17	0.45	0.17	neutral	0.75	disease	0.25	neutral	0.53	disease	1	0.74	neutral	0.59	deleterious	-3	neutral	0.21	neutral	0.37	medium_impact	-0.01	medium_impact	1.34	medium_impact	0.34	0.8	18.87	12.35	0.58	P	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4168	4168	C	G	MI.12554	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	862	288	L	V	Ctc/Gtc	-2.04	0	0	probably_damaging	1	neutral	0.45	neutral	2.06	deleterious	-3.12	deleterious	-2.64	medium_impact	3.44	0.68	neutral	0.1	damaging	3.55	23.10	deleterious	0.2	0.45	0.33	neutral	0.64	disease	0.61	disease	0.65	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.23	medium_impact	1.82	medium_impact	0.59	0.8	59.43	10.44	0.27	N	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4168	4168	C	A	MI.12555	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	862	288	L	I	Ctc/Atc	-2.04	0	0	probably_damaging	1	neutral	0.39	neutral	2.13	neutral	-2.49	neutral	-1.76	medium_impact	2.97	0.79	neutral	0.14	damaging	4.38	24.10	deleterious	0.24	0.45	0.31	neutral	0.69	disease	0.6	disease	0.65	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.17	medium_impact	1.41	medium_impact	0.50	0.8	59.43	10.44	0.23	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4168	4168	C	T	MI.12556	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	862	288	L	F	Ctc/Ttc	-2.04	0	0	probably_damaging	1	neutral	0.65	neutral	2.05	deleterious	-3.26	deleterious	-3.52	medium_impact	2.29	0.69	neutral	0.08	damaging	4.08	23.70	deleterious	0.15	0.4	0.38	neutral	0.71	disease	0.65	disease	0.67	disease	3	1	deleterious	0.33	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.43	medium_impact	0.81	medium_impact	0.57	0.8	59.43	10.44	0.19	N	0.95	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4169	4169	T	A	MI.12557	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	863	288	L	H	cTc/cAc	-0.2	0	0	probably_damaging	1	neutral	0.46	neutral	1.93	deleterious	-6.86	deleterious	-6.16	high_impact	4.54	0.72	neutral	0.09	damaging	4.30	24.00	deleterious	0.02	0.35	0.84	disease	0.84	disease	0.74	disease	0.79	disease	6	1	deleterious	0.23	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	0.24	medium_impact	2.78	high_impact	0.28	0.8	59.43	10.44	0.45	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4169	4169	T	C	MI.12558	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	863	288	L	P	cTc/cCc	-0.2	0	0	probably_damaging	1	neutral	0.2	neutral	1.94	deleterious	-6.8	deleterious	-6.18	high_impact	4.2	0.78	neutral	0.08	damaging	4.07	23.70	deleterious	0.01	0.35	0.83	disease	0.82	disease	0.75	disease	0.8	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.06	medium_impact	2.48	high_impact	0.38	0.8	59.43	10.44	0.35	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4169	4169	T	G	MI.12559	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	863	288	L	R	cTc/cGc	-0.2	0	0	probably_damaging	1	neutral	0.37	neutral	1.94	deleterious	-6.24	deleterious	-5.28	high_impact	4.54	0.76	neutral	0.07	damaging	4.36	24.10	deleterious	0.01	0.35	0.78	disease	0.89	disease	0.76	disease	0.82	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.88	deleterious	-3.57	low_impact	0.15	medium_impact	2.78	high_impact	0.15	0.8	59.43	10.44	0.49	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9116	9116	T	G	MI.1256	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	590	197	I	S	aTt/aGt	-4.73	0	0	benign	0.02	neutral	0.07	neutral	4.27	neutral	-2.95	deleterious	-2.92	low_impact	1.6	0.83	neutral	0.46	neutral	2.50	19.47	deleterious	0.28	0.65	NA	NA	0.58	disease	0.47	neutral	0.46	neutral	1	0.93	neutral	0.53	deleterious	-6	neutral	0.19	neutral	0.85	medium_impact	-0.34	medium_impact	0.27	medium_impact	0.34	0.9	24.78	14.04	0.38	N	0.25	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4171	4171	C	G	MI.12560	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	865	289	L	V	Cta/Gta	-13.09	0	0.01	probably_damaging	1	neutral	0.49	neutral	2.79	neutral	-0.82	neutral	-0.28	neutral_impact	0.46	0.88	neutral	0.71	neutral	1.77	14.81	neutral	0.22	0.45	0.17	neutral	0.17	neutral	0.16	neutral	0.29	neutral	4	1	deleterious	0.25	neutral	-2	neutral	0.65	deleterious	-3.57	low_impact	0.27	medium_impact	-0.79	medium_impact	0.52	0.8	59.43	10.63	0.47	N	0.84	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4171	4171	C	A	MI.12561	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	865	289	L	M	Cta/Ata	-13.09	0	0.01	probably_damaging	1	neutral	0.24	neutral	2.7	neutral	-1.96	neutral	-0.98	low_impact	1.76	0.75	neutral	0.56	neutral	3.81	23.40	deleterious	0.22	0.45	0.32	neutral	0.32	neutral	0.18	neutral	0.48	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	-0.01	medium_impact	0.35	medium_impact	0.44	0.8	59.43	10.63	0.6	P	0.89	disease_causing_automatic	0	0.03	rs28616230	Pathogenic	Leber's_optic_atrophy	24771	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	C4171A	LHON	+	+	Cfrm	7	P	P	P	damaging
chrM	4172	4172	T	A	MI.12562	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	866	289	L	Q	cTa/cAa	-0.66	0	0	probably_damaging	1	neutral	0.33	neutral	2.71	neutral	-2.72	deleterious	-4.14	medium_impact	3.21	0.74	neutral	0.33	neutral	4.23	23.90	deleterious	0.04	0.35	0.38	neutral	0.68	disease	0.37	neutral	0.49	neutral	0	1	deleterious	0.17	neutral	1	deleterious	0.74	deleterious	-3.57	low_impact	0.1	medium_impact	1.62	medium_impact	0.24	0.8	59.43	10.63	0.39	N	0.99	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4172	4172	T	G	MI.12563	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	866	289	L	R	cTa/cGa	-0.66	0	0	probably_damaging	1	neutral	0.35	neutral	2.71	neutral	-2.67	deleterious	-4.38	medium_impact	3.21	0.71	neutral	0.28	damaging	4.35	24.10	deleterious	0.02	0.35	0.39	neutral	0.85	disease	0.51	disease	0.72	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.57	low_impact	0.12	medium_impact	1.62	medium_impact	0.17	0.8	59.43	10.63	0.36	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4172	4172	T	C	MI.12564	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	866	289	L	P	cTa/cCa	-0.66	0	0	probably_damaging	1	neutral	0.23	neutral	2.68	deleterious	-3.48	deleterious	-4.57	medium_impact	2.51	0.65	neutral	0.26	damaging	4.07	23.70	deleterious	0.02	0.35	0.51	disease	0.85	disease	0.53	disease	0.74	disease	5	1	deleterious	0.12	neutral	1	deleterious	0.83	deleterious	-3.57	low_impact	-0.02	medium_impact	1	medium_impact	0.19	0.8	59.43	10.63	0.3	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4174	4174	T	G	MI.12565	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	868	290	W	G	Tga/Gga	-0.66	0.06	0	probably_damaging	1	neutral	0.35	neutral	1.99	deleterious	-5.36	deleterious	-11.62	high_impact	4.39	0.69	neutral	0.12	damaging	4.04	23.70	deleterious	0.02	0.35	0.72	disease	0.84	disease	0.76	disease	0.78	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	0.12	medium_impact	2.65	high_impact	0.04	0.8	60.06	10.24	0.48	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4174	4174	T	C	MI.12566	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	868	290	W	R	Tga/Cga	-0.66	0.06	0	probably_damaging	1	neutral	0.37	neutral	2.05	deleterious	-3.78	deleterious	-12.52	high_impact	4.19	0.7	neutral	0.08	damaging	3.72	23.30	deleterious	0.02	0.35	0.5	neutral	0.91	disease	0.79	disease	0.79	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.15	medium_impact	2.47	high_impact	0.03	0.8	60.06	10.24	0.51	N	0.98	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4175	4175	G	T	MI.12567	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	869	290	W	L	tGa/tTa	5.55	1	0	probably_damaging	1	neutral	0.89	neutral	2.04	deleterious	-3.92	deleterious	-11.62	high_impact	4.39	0.74	neutral	0.1	damaging	4.38	24.10	deleterious	0.03	0.35	0.44	neutral	0.86	disease	0.72	disease	0.75	disease	5	1	deleterious	0.45	neutral	2	deleterious	0.80	deleterious	-3.57	low_impact	0.78	medium_impact	2.65	high_impact	0.03	0.8	60.06	10.24	0.54	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4175	4175	G	C	MI.12568	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	869	290	W	S	tGa/tCa	5.55	1	0	probably_damaging	1	neutral	0.42	neutral	2.01	deleterious	-4.72	deleterious	-12.52	high_impact	4.19	0.69	neutral	0.13	damaging	4.17	23.80	deleterious	0.02	0.35	0.6	disease	0.88	disease	0.74	disease	0.77	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.84	deleterious	-3.57	low_impact	0.2	medium_impact	2.47	high_impact	0.03	0.8	60.06	10.24	0.58	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4176	4176	A	T	MI.12569	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	870	290	W	C	tgA/tgT	9.01	1	0	probably_damaging	1	neutral	0.18	neutral	1.98	deleterious	-6.71	deleterious	-11.62	high_impact	4.39	0.69	neutral	0.08	damaging	4.28	24.00	deleterious	0.02	0.35	0.82	disease	0.88	disease	0.77	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.09	medium_impact	2.65	high_impact	0.06	0.8	60.06	10.24	0.62	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9116	9116	T	C	MI.1257	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	590	197	I	T	aTt/aCt	-4.73	0	0	benign	0	neutral	0.2	neutral	4.28	neutral	-2.08	neutral	-2.02	low_impact	1.36	0.98	neutral	0.95	neutral	0.21	4.78	deleterious	0.38	0.65	NA	NA	0.26	neutral	0.38	neutral	0.16	neutral	7	0.8	neutral	0.6	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	-0.05	medium_impact	0.07	medium_impact	0.42	0.9	24.78	14.04	0.42	N	0.04	polymorphism	1	0.04	rs376203575	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4176	4176	A	C	MI.12570	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	870	290	W	C	tgA/tgC	9.01	1	0	probably_damaging	1	neutral	0.18	neutral	1.98	deleterious	-6.71	deleterious	-11.62	high_impact	4.39	0.69	neutral	0.08	damaging	4.15	23.80	deleterious	0.02	0.35	0.82	disease	0.88	disease	0.77	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.57	low_impact	-0.09	medium_impact	2.65	high_impact	0.06	0.8	60.06	10.24	0.62	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4177	4177	A	G	MI.12571	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	871	291	K	E	Aaa/Gaa	4.63	1	0	probably_damaging	1	neutral	0.14	neutral	2.35	neutral	-2.87	deleterious	-3.56	high_impact	3.51	0.68	neutral	0.06	damaging	4.18	23.80	deleterious	0.11	0.4	0.29	neutral	0.82	disease	0.64	disease	0.68	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.17	medium_impact	1.88	medium_impact	0.40	0.8	59.12	10.4	0.54	P	0.92	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4177	4177	A	C	MI.12572	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	871	291	K	Q	Aaa/Caa	4.63	1	0	probably_damaging	1	neutral	0.28	neutral	2.33	deleterious	-3.18	deleterious	-3.56	high_impact	3.71	0.61	neutral	0.07	damaging	3.65	23.20	deleterious	0.18	0.45	0.35	neutral	0.79	disease	0.65	disease	0.68	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.05	medium_impact	2.05	high_impact	0.43	0.8	59.12	10.4	0.56	P	0.92	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4178	4178	A	C	MI.12573	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	872	291	K	T	aAa/aCa	8.55	1	0	probably_damaging	1	neutral	0.26	neutral	2.32	deleterious	-3.36	deleterious	-5.33	medium_impact	3.13	0.59	damaging	0.07	damaging	3.55	23.10	deleterious	0.07	0.35	0.3	neutral	0.78	disease	0.68	disease	0.69	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	0.02	medium_impact	1.55	medium_impact	0.28	0.8	59.12	10.4	0.53	P	0.82	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4178	4178	A	T	MI.12574	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	872	291	K	M	aAa/aTa	8.55	1	0	probably_damaging	1	neutral	0.41	neutral	2.29	deleterious	-4.65	deleterious	-5.34	medium_impact	3.46	0.65	neutral	0.05	damaging	3.83	23.40	deleterious	0.07	0.35	0.6	disease	0.81	disease	0.66	disease	0.7	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.19	medium_impact	1.83	medium_impact	0.15	0.8	59.12	10.4	0.55	P	0.50	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4179	4179	A	T	MI.12575	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	873	291	K	N	aaA/aaT	6.71	1	0	probably_damaging	1	neutral	0.15	neutral	2.32	deleterious	-3.54	deleterious	-4.45	high_impact	3.71	0.63	neutral	0.06	damaging	3.87	23.50	deleterious	0.19	0.45	0.39	neutral	0.8	disease	0.66	disease	0.69	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.15	medium_impact	2.05	high_impact	0.37	0.8	59.12	10.4	0.61	P	0.84	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4179	4179	A	C	MI.12576	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	873	291	K	N	aaA/aaC	6.71	1	0	probably_damaging	1	neutral	0.15	neutral	2.32	deleterious	-3.54	deleterious	-4.45	high_impact	3.71	0.63	neutral	0.06	damaging	3.79	23.40	deleterious	0.19	0.45	0.39	neutral	0.8	disease	0.66	disease	0.69	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.78	deleterious	-3.57	low_impact	-0.15	medium_impact	2.05	high_impact	0.37	0.8	59.12	10.4	0.6	P	0.84	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4180	4180	A	C	MI.12577	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	874	292	N	H	Aac/Cac	4.63	1	0	probably_damaging	0.96	neutral	0.56	neutral	2.74	neutral	-1.11	deleterious	-3.87	medium_impact	3.15	0.72	neutral	0.39	neutral	3.10	22.50	deleterious	0.28	0.45	0.36	neutral	0.67	disease	0.31	neutral	0.49	neutral	0	0.96	neutral	0.3	neutral	1	deleterious	0.68	deleterious	-2.05	low_impact	0.33	medium_impact	1.56	medium_impact	0.20	0.8	55.97	9.7	0.47	N	0.79	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4180	4180	A	T	MI.12578	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	874	292	N	Y	Aac/Tac	4.63	1	0	probably_damaging	0.96	neutral	1	neutral	2.75	neutral	1.2	deleterious	-6.25	medium_impact	2	0.72	neutral	0.4	neutral	3.64	23.20	deleterious	0.12	0.4	0.29	neutral	0.71	disease	0.41	neutral	0.5	neutral	0	0.96	neutral	0.52	deleterious	1	deleterious	0.70	deleterious	-2.05	low_impact	1.96	high_impact	0.56	medium_impact	0.13	0.8	55.97	9.7	0.38	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4180	4180	A	G	MI.12579	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	874	292	N	D	Aac/Gac	4.63	1	0	possibly_damaging	0.64	neutral	0.2	neutral	2.76	neutral	-1.28	deleterious	-3.82	medium_impact	2.69	0.74	neutral	0.48	neutral	3.83	23.40	deleterious	0.38	0.5	0.26	neutral	0.61	disease	0.38	neutral	0.49	neutral	0	0.82	neutral	0.28	neutral	0	NA	0.51	deleterious	-0.99	medium_impact	-0.06	medium_impact	1.16	medium_impact	0.29	0.8	55.97	9.7	0.67	P	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9116	9116	T	A	MI.1258	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	590	197	I	N	aTt/aAt	-4.73	0	0	benign	0.04	neutral	0.1	neutral	4.26	deleterious	-4.32	deleterious	-3.94	medium_impact	2.38	0.84	neutral	0.45	neutral	2.78	21.30	deleterious	0.24	0.65	NA	NA	0.6	disease	0.56	disease	0.68	disease	4	0.89	neutral	0.53	deleterious	-3	neutral	0.28	neutral	0.55	medium_impact	-0.25	medium_impact	0.94	medium_impact	0.40	0.9	24.78	14.04	0.38	N	0.49	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4181	4181	A	T	MI.12580	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	875	292	N	I	aAc/aTc	6.71	1	0	probably_damaging	0.93	neutral	0.41	neutral	2.81	neutral	2.24	deleterious	-7.14	low_impact	1.54	0.74	neutral	0.47	neutral	3.87	23.50	deleterious	0.13	0.4	0.19	neutral	0.75	disease	0.24	neutral	0.49	neutral	0	0.93	neutral	0.24	neutral	-2	neutral	0.66	deleterious	-1.81	low_impact	0.19	medium_impact	0.16	medium_impact	0.11	0.8	55.97	9.7	0.51	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4181	4181	A	G	MI.12581	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	875	292	N	S	aAc/aGc	6.71	1	0	benign	0.13	neutral	0.42	neutral	2.82	neutral	1.1	deleterious	-3.61	low_impact	1.12	0.79	neutral	0.9	neutral	1.95	15.89	deleterious	0.37	0.5	0.14	neutral	0.19	neutral	0.19	neutral	0.34	neutral	3	0.51	neutral	0.65	deleterious	-6	neutral	0.15	neutral	0.02	medium_impact	0.2	medium_impact	-0.21	medium_impact	0.24	0.8	55.97	9.7	0.56	P	0.46	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4181	4181	A	C	MI.12582	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	875	292	N	T	aAc/aCc	6.71	1	0	possibly_damaging	0.64	neutral	0.39	neutral	2.8	neutral	1.01	deleterious	-4.52	low_impact	1.38	0.72	neutral	0.55	neutral	3.38	22.90	deleterious	0.24	0.45	0.2	neutral	0.5	neutral	0.23	neutral	0.44	neutral	1	0.68	neutral	0.38	neutral	-3	neutral	0.46	deleterious	-0.99	medium_impact	0.17	medium_impact	0.02	medium_impact	0.32	0.8	55.97	9.7	0.59	P	0.76	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4182	4182	C	G	MI.12583	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	876	292	N	K	aaC/aaG	1.41	0.59	0	benign	0.05	neutral	0.31	neutral	2.83	neutral	0.67	deleterious	-4.48	low_impact	1.76	0.72	neutral	0.53	neutral	4.13	23.80	deleterious	0.28	0.45	0.15	neutral	0.68	disease	0.28	neutral	0.48	neutral	0	0.66	neutral	0.63	deleterious	-6	neutral	0.16	neutral	0.45	medium_impact	0.08	medium_impact	0.35	medium_impact	0.24	0.8	55.97	9.7	0.36	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4182	4182	C	A	MI.12584	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	876	292	N	K	aaC/aaA	1.41	0.59	0	benign	0.05	neutral	0.31	neutral	2.83	neutral	0.67	deleterious	-4.48	low_impact	1.76	0.72	neutral	0.53	neutral	4.54	24.30	deleterious	0.28	0.45	0.15	neutral	0.68	disease	0.28	neutral	0.48	neutral	0	0.66	neutral	0.63	deleterious	-6	neutral	0.16	neutral	0.45	medium_impact	0.08	medium_impact	0.35	medium_impact	0.24	0.8	55.97	9.7	0.36	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4183	4183	T	G	MI.12585	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	877	293	F	V	Ttc/Gtc	-3.88	0	0	probably_damaging	1	neutral	0.32	neutral	2.65	deleterious	-9.76	deleterious	-6.07	medium_impact	3.15	0.65	neutral	0.13	damaging	4.30	24.00	deleterious	0.08	0.35	0.25	neutral	0.79	disease	0.61	disease	0.68	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.09	medium_impact	1.56	medium_impact	0.29	0.8	58.81	10.26	0.3	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4183	4183	T	A	MI.12586	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	877	293	F	I	Ttc/Atc	-3.88	0	0	probably_damaging	1	neutral	0.27	neutral	2.63	deleterious	-9.7	deleterious	-5.2	medium_impact	2.04	0.73	neutral	0.16	damaging	4.74	24.70	deleterious	0.15	0.45	0.24	neutral	0.81	disease	0.52	disease	0.65	disease	3	1	deleterious	0.14	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.03	medium_impact	0.59	medium_impact	0.50	0.8	58.81	10.26	0.34	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4183	4183	T	C	MI.12587	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	877	293	F	L	Ttc/Ctc	-3.88	0	0	probably_damaging	1	neutral	1	neutral	2.83	deleterious	-8.42	deleterious	-5.2	low_impact	1.68	0.76	neutral	0.14	damaging	4.28	24.00	deleterious	0.18	0.45	0.13	neutral	0.76	disease	0.48	neutral	0.56	disease	1	1	deleterious	0.5	deleterious	-2	neutral	0.68	deleterious	-3.57	low_impact	1.96	high_impact	0.28	medium_impact	0.72	0.85	58.81	10.26	0.26	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4184	4184	T	G	MI.12588	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	878	293	F	C	tTc/tGc	7.4	1	0	probably_damaging	1	neutral	0.14	neutral	2.56	deleterious	-11.79	deleterious	-6.96	medium_impact	2.81	0.71	neutral	0.13	damaging	4.24	23.90	deleterious	0.06	0.35	0.65	disease	0.81	disease	0.64	disease	0.68	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	-0.17	medium_impact	1.27	medium_impact	0.15	0.8	58.81	10.26	0.47	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4184	4184	T	C	MI.12589	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	878	293	F	S	tTc/tCc	7.4	1	0	probably_damaging	1	neutral	0.32	neutral	2.57	deleterious	-10.45	deleterious	-6.91	medium_impact	3.04	0.7	neutral	0.16	damaging	4.38	24.10	deleterious	0.03	0.35	0.45	neutral	0.77	disease	0.62	disease	0.68	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.09	medium_impact	1.47	medium_impact	0.14	0.8	58.81	10.26	0.47	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9117	9117	T	A	MI.1259	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	591	197	I	M	atT/atA	3.83	0.45	0	benign	0.35	neutral	0.29	neutral	4.32	neutral	-2.35	neutral	-0.84	low_impact	1.15	0.91	neutral	0.92	neutral	0.97	10.48	neutral	0.28	0.65	NA	NA	0.23	neutral	0.27	neutral	0.16	neutral	7	0.65	neutral	0.47	deleterious	-6	neutral	0.43	neutral	-0.5	medium_impact	0.07	medium_impact	-0.11	medium_impact	0.49	0.9	24.78	14.04	0.46	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4184	4184	T	A	MI.12590	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	878	293	F	Y	tTc/tAc	7.4	1	0	probably_damaging	1	neutral	0.7	neutral	2.64	deleterious	-7.65	deleterious	-2.58	low_impact	1.74	0.71	neutral	0.15	damaging	4.36	24.10	deleterious	0.18	0.45	0.51	disease	0.42	neutral	0.33	neutral	0.29	neutral	4	1	deleterious	0.35	neutral	-2	neutral	0.73	deleterious	-3.57	low_impact	0.48	medium_impact	0.33	medium_impact	0.56	0.8	58.81	10.26	0.5	N	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4185	4185	C	G	MI.12591	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	879	293	F	L	ttC/ttG	7.4	1	0	probably_damaging	1	neutral	1	neutral	2.83	deleterious	-8.42	deleterious	-5.2	low_impact	1.68	0.76	neutral	0.14	damaging	4.49	24.30	deleterious	0.18	0.45	0.13	neutral	0.76	disease	0.48	neutral	0.56	disease	1	1	deleterious	0.5	deleterious	-2	neutral	0.68	deleterious	-3.57	low_impact	1.96	high_impact	0.28	medium_impact	0.72	0.85	58.81	10.26	0.39	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4185	4185	C	A	MI.12592	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	879	293	F	L	ttC/ttA	7.4	1	0	probably_damaging	1	neutral	1	neutral	2.83	deleterious	-8.42	deleterious	-5.2	low_impact	1.68	0.76	neutral	0.14	damaging	4.82	24.80	deleterious	0.18	0.45	0.13	neutral	0.76	disease	0.48	neutral	0.56	disease	1	1	deleterious	0.5	deleterious	-2	neutral	0.68	deleterious	-3.57	low_impact	1.96	high_impact	0.28	medium_impact	0.72	0.85	58.81	10.26	0.39	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4186	4186	C	G	MI.12593	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	880	294	L	V	Cta/Gta	-2.73	0	0	probably_damaging	1	neutral	0.35	neutral	1.66	deleterious	-7.96	deleterious	-2.65	medium_impact	3.18	0.65	neutral	0.11	damaging	3.52	23.10	deleterious	0.27	0.45	0.27	neutral	0.4	neutral	0.66	disease	0.42	neutral	2	1	deleterious	0.18	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.12	medium_impact	1.59	medium_impact	0.46	0.8	60.06	10.16	0.33	N	0.84	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4186	4186	C	A	MI.12594	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	880	294	L	M	Cta/Ata	-2.73	0	0	probably_damaging	1	neutral	0.27	neutral	1.62	deleterious	-8.24	neutral	-1.77	medium_impact	3.38	0.79	neutral	0.16	damaging	3.85	23.40	deleterious	0.24	0.45	0.52	disease	0.46	neutral	0.65	disease	0.5	neutral	0	1	deleterious	0.14	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.03	medium_impact	1.76	medium_impact	0.37	0.8	60.06	10.16	0.33	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4187	4187	T	C	MI.12595	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	881	294	L	P	cTa/cCa	-0.43	0	0	probably_damaging	1	neutral	0.21	neutral	1.57	deleterious	-11	deleterious	-6.18	high_impact	3.93	0.71	neutral	0.1	damaging	4.02	23.60	deleterious	0.02	0.35	0.72	disease	0.68	disease	0.74	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	-0.05	medium_impact	2.24	high_impact	0.29	0.8	60.06	10.16	0.33	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4187	4187	T	A	MI.12596	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	881	294	L	Q	cTa/cAa	-0.43	0	0	probably_damaging	1	neutral	0.24	neutral	1.58	deleterious	-10.85	deleterious	-5.3	high_impact	4.62	0.7	neutral	0.11	damaging	4.18	23.80	deleterious	0.03	0.35	0.64	disease	0.7	disease	0.67	disease	0.68	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	-0.01	medium_impact	2.85	high_impact	0.29	0.8	60.06	10.16	0.44	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4187	4187	T	G	MI.12597	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	881	294	L	R	cTa/cGa	-0.43	0	0	probably_damaging	1	neutral	0.22	neutral	1.58	deleterious	-10.71	deleterious	-5.3	high_impact	4.62	0.71	neutral	0.09	damaging	4.31	24.00	deleterious	0.02	0.35	0.62	disease	0.8	disease	0.77	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.57	low_impact	-0.03	medium_impact	2.85	high_impact	0.20	0.8	60.06	10.16	0.48	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4189	4189	C	A	MI.12598	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	883	295	P	T	Cca/Aca	-10.1	0	0	probably_damaging	1	neutral	0.37	neutral	2.09	deleterious	-11.95	deleterious	-7.02	high_impact	4.16	0.66	neutral	0.11	damaging	3.78	23.40	deleterious	0.11	0.4	0.41	neutral	0.74	disease	0.56	disease	0.65	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.15	medium_impact	2.44	high_impact	0.54	0.8	59.43	10.47	0.3	N	0.91	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4189	4189	C	T	MI.12599	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	883	295	P	S	Cca/Tca	-10.1	0	0	probably_damaging	1	neutral	0.44	neutral	2.14	deleterious	-11.53	deleterious	-7.02	high_impact	3.81	0.72	neutral	0.14	damaging	3.99	23.60	deleterious	0.1	0.4	0.32	neutral	0.71	disease	0.56	disease	0.59	disease	2	1	deleterious	0.22	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	0.22	medium_impact	2.14	high_impact	0.17	0.8	59.43	10.47	0.29	N	0.74	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8585	8585	C	G	MI.126	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	59	20	A	G	gCa/gGa	-1.49	0	0	benign	0.28	neutral	0.33	neutral	4.58	neutral	-2.08	deleterious	-2.85	low_impact	1.1	0.87	neutral	0.57	neutral	2.00	16.19	deleterious	0.3	0.65	0.72	disease	0.37	neutral	0.42	neutral	0.65	disease	3	0.6	neutral	0.53	deleterious	-6	neutral	0.36	neutral	-0.37	medium_impact	0.12	medium_impact	-0.16	medium_impact	0.52	0.9	24.78	23.03	0.38	N	0.53	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9117	9117	T	G	MI.1260	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	591	197	I	M	atT/atG	3.83	0.45	0	benign	0.35	neutral	0.29	neutral	4.32	neutral	-2.35	neutral	-0.84	low_impact	1.15	0.91	neutral	0.92	neutral	0.65	8.50	deleterious	0.28	0.65	NA	NA	0.23	neutral	0.27	neutral	0.16	neutral	7	0.65	neutral	0.47	deleterious	-6	neutral	0.43	neutral	-0.5	medium_impact	0.07	medium_impact	-0.11	medium_impact	0.49	0.9	24.78	14.04	0.45	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4189	4189	C	G	MI.12600	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	883	295	P	A	Cca/Gca	-10.1	0	0	probably_damaging	1	neutral	0.48	neutral	2.13	deleterious	-11.19	deleterious	-7.02	high_impact	4.16	0.7	neutral	0.14	damaging	3.18	22.70	deleterious	0.12	0.4	0.34	neutral	0.64	disease	0.62	disease	0.66	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.73	deleterious	-3.57	low_impact	0.26	medium_impact	2.44	high_impact	0.54	0.8	59.43	10.47	0.31	N	0.78	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4190	4190	C	A	MI.12601	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	884	295	P	Q	cCa/cAa	7.17	1	0	probably_damaging	1	neutral	0.31	neutral	2.06	deleterious	-12.98	deleterious	-7.03	high_impact	4.36	0.72	neutral	0.11	damaging	4.21	23.90	deleterious	0.09	0.35	0.5	neutral	0.83	disease	0.66	disease	0.72	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.77	deleterious	-3.57	low_impact	0.08	medium_impact	2.62	high_impact	0.30	0.8	59.43	10.47	0.51	P	0.84	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4190	4190	C	T	MI.12602	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	884	295	P	L	cCa/cTa	7.17	1	0	probably_damaging	1	neutral	0.87	neutral	2.06	deleterious	-12.46	deleterious	-8.79	high_impact	3.9	0.78	neutral	0.11	damaging	4.42	24.20	deleterious	0.07	0.35	0.33	neutral	0.87	disease	0.6	disease	0.71	disease	4	1	deleterious	0.44	neutral	2	deleterious	0.76	deleterious	-3.57	low_impact	0.74	medium_impact	2.22	high_impact	0.53	0.8	59.43	10.47	0.45	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4190	4190	C	G	MI.12603	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	884	295	P	R	cCa/cGa	7.17	1	0	probably_damaging	1	neutral	0.33	neutral	2.06	deleterious	-12.49	deleterious	-7.91	high_impact	4.16	0.81	neutral	0.13	damaging	3.62	23.20	deleterious	0.04	0.35	0.51	disease	0.88	disease	0.72	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.81	deleterious	-3.57	low_impact	0.1	medium_impact	2.44	high_impact	0.37	0.8	59.43	10.47	0.55	N	0.71	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4192	4192	C	T	MI.12604	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	886	296	L	F	Ctc/Ttc	-14.47	0	0	probably_damaging	0.97	neutral	0.54	neutral	2.27	deleterious	-3.45	deleterious	-2.75	medium_impact	2.05	0.74	neutral	0.11	damaging	4.08	23.70	deleterious	0.2	0.45	0.34	neutral	0.55	disease	0.32	neutral	0.46	neutral	1	0.97	neutral	0.29	neutral	1	deleterious	0.71	deleterious	-2.17	low_impact	0.31	medium_impact	0.6	medium_impact	0.62	0.8	20.44	16.14	0.22	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4192	4192	C	A	MI.12605	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	886	296	L	I	Ctc/Atc	-14.47	0	0	possibly_damaging	0.86	neutral	0.31	neutral	2.5	neutral	0.8	neutral	-0.79	low_impact	1.39	0.88	neutral	0.83	neutral	2.79	21.30	deleterious	0.31	0.45	0.18	neutral	0.25	neutral	0.23	neutral	0.43	neutral	1	0.88	neutral	0.23	neutral	-3	neutral	0.63	deleterious	-1.49	low_impact	0.08	medium_impact	0.03	medium_impact	0.58	0.8	20.44	16.14	0.43	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4192	4192	C	G	MI.12606	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	886	296	L	V	Ctc/Gtc	-14.47	0	0	possibly_damaging	0.86	neutral	0.42	neutral	2.47	neutral	-2.33	neutral	-1.47	medium_impact	2.19	0.82	neutral	0.18	damaging	3.50	23.10	deleterious	0.31	0.45	0.25	neutral	0.35	neutral	0.27	neutral	0.44	neutral	1	0.85	neutral	0.28	neutral	0	NA	0.63	deleterious	-1.49	low_impact	0.2	medium_impact	0.72	medium_impact	0.51	0.8	20.44	16.14	0.32	N	0.65	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4193	4193	T	A	MI.12607	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	887	296	L	H	cTc/cAc	-0.89	0	0	probably_damaging	0.99	neutral	0.3	neutral	2.21	deleterious	-7.04	deleterious	-5.21	high_impact	4.24	0.72	neutral	0.08	damaging	4.37	24.10	deleterious	0.06	0.35	0.79	disease	0.79	disease	0.64	disease	0.74	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-2.62	low_impact	0.07	medium_impact	2.51	high_impact	0.26	0.8	20.44	16.14	0.34	N	0.88	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4193	4193	T	G	MI.12608	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	887	296	L	R	cTc/cGc	-0.89	0	0	probably_damaging	0.98	neutral	0.19	neutral	2.21	deleterious	-6.29	deleterious	-4.55	high_impact	3.9	0.65	neutral	0.08	damaging	4.29	24.00	deleterious	0.03	0.35	0.72	disease	0.88	disease	0.68	disease	0.75	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-2.34	low_impact	-0.08	medium_impact	2.22	high_impact	0.24	0.8	20.44	16.14	0.33	N	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4193	4193	T	C	MI.12609	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	887	296	L	P	cTc/cCc	-0.89	0	0	probably_damaging	0.99	neutral	0.17	neutral	2.21	deleterious	-6.63	deleterious	-5.19	high_impact	4.24	0.64	neutral	0.08	damaging	4.07	23.70	deleterious	0.04	0.35	0.78	disease	0.86	disease	0.68	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-2.62	low_impact	-0.11	medium_impact	2.51	high_impact	0.25	0.8	20.44	16.14	0.34	N	0.94	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9118	9118	C	G	MI.1261	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	592	198	L	V	Cta/Gta	-12.6	0	0	probably_damaging	0.99	neutral	0.09	neutral	4.31	neutral	-0.11	deleterious	-2.56	medium_impact	2.3	0.93	neutral	0.54	neutral	3.48	23.10	deleterious	0.39	0.65	NA	NA	0.57	disease	0.37	neutral	0.46	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.82	deleterious	-2.65	low_impact	-0.28	medium_impact	0.87	medium_impact	0.62	0.9	42.04	7.67	0.47	N	0.87	polymorphism	1	0.07	rs28520706	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4195	4195	A	T	MI.12610	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	889	297	T	S	Acc/Tcc	-9.41	0	0	probably_damaging	1	neutral	0.44	neutral	3.02	deleterious	-8.17	deleterious	-3.12	low_impact	1.45	0.8	neutral	0.16	damaging	3.39	23.00	deleterious	0.33	0.5	0.11	neutral	0.21	neutral	0.24	neutral	0.33	neutral	3	1	deleterious	0.22	neutral	-2	neutral	0.66	deleterious	-3.57	low_impact	0.22	medium_impact	0.08	medium_impact	0.70	0.85	61.32	9.85	0.29	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4195	4195	A	G	MI.12611	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	889	297	T	A	Acc/Gcc	-9.41	0	0	probably_damaging	1	neutral	0.5	neutral	2.75	deleterious	-7.85	deleterious	-3.87	low_impact	1.75	0.77	neutral	0.17	damaging	3.56	23.10	deleterious	0.22	0.45	0.13	neutral	0.62	disease	0.31	neutral	0.43	neutral	2	1	deleterious	0.25	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.28	medium_impact	0.34	medium_impact	0.37	0.8	61.32	9.85	0.22	N	0.65	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4195	4195	A	C	MI.12612	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	889	297	T	P	Acc/Ccc	-9.41	0	0	probably_damaging	1	neutral	0.23	neutral	2.58	deleterious	-9.86	deleterious	-4.9	medium_impact	3.25	0.73	neutral	0.09	damaging	3.58	23.20	deleterious	0.05	0.35	0.47	neutral	0.9	disease	0.66	disease	0.75	disease	5	1	deleterious	0.12	neutral	1	deleterious	0.79	deleterious	-3.57	low_impact	-0.02	medium_impact	1.65	medium_impact	0.41	0.8	61.32	9.85	0.29	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4196	4196	C	A	MI.12613	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	890	297	T	N	aCc/aAc	5.55	1	0	probably_damaging	1	neutral	0.34	neutral	2.6	deleterious	-9.77	deleterious	-4.11	medium_impact	2.98	0.73	neutral	0.09	damaging	3.79	23.40	deleterious	0.23	0.45	0.23	neutral	0.86	disease	0.53	disease	0.72	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.11	medium_impact	1.41	medium_impact	0.53	0.8	61.32	9.85	0.45	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4196	4196	C	T	MI.12614	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	890	297	T	I	aCc/aTc	5.55	1	0	probably_damaging	1	neutral	0.4	neutral	2.59	deleterious	-9.94	deleterious	-4.72	medium_impact	2.32	0.76	neutral	0.09	damaging	4.11	23.70	deleterious	0.1	0.4	0.27	neutral	0.87	disease	0.5	neutral	0.74	disease	5	1	deleterious	0.2	neutral	1	deleterious	0.73	deleterious	-3.57	low_impact	0.18	medium_impact	0.84	medium_impact	0.54	0.8	61.32	9.85	0.43	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4196	4196	C	G	MI.12615	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	890	297	T	S	aCc/aGc	5.55	1	0	probably_damaging	1	neutral	0.44	neutral	3.02	deleterious	-8.17	deleterious	-3.12	low_impact	1.45	0.8	neutral	0.16	damaging	3.63	23.20	deleterious	0.33	0.5	0.11	neutral	0.21	neutral	0.24	neutral	0.33	neutral	3	1	deleterious	0.22	neutral	-2	neutral	0.66	deleterious	-3.57	low_impact	0.22	medium_impact	0.08	medium_impact	0.70	0.85	61.32	9.85	0.5	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4198	4198	C	G	MI.12616	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	892	298	L	V	Cta/Gta	-7.11	0	0	probably_damaging	1	neutral	0.39	neutral	1.91	deleterious	-7.96	neutral	-2.39	medium_impact	3.1	0.66	neutral	0.05	damaging	3.54	23.10	deleterious	0.13	0.4	0.51	disease	0.56	disease	0.64	disease	0.64	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.75	deleterious	-3.57	low_impact	0.17	medium_impact	1.52	medium_impact	0.47	0.8	59.75	9.48	0.25	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4198	4198	C	A	MI.12617	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	892	298	L	M	Cta/Ata	-7.11	0	0	probably_damaging	1	neutral	0.25	neutral	1.85	deleterious	-8.24	neutral	-1.67	medium_impact	2.88	0.7	neutral	0.13	damaging	3.86	23.50	deleterious	0.14	0.4	0.48	neutral	0.51	disease	0.53	disease	0.47	neutral	1	1	deleterious	0.13	neutral	1	deleterious	0.72	deleterious	-3.57	low_impact	0.01	medium_impact	1.33	medium_impact	0.48	0.8	59.75	9.48	0.31	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4199	4199	T	C	MI.12618	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	893	298	L	P	cTa/cCa	-0.2	0	0	probably_damaging	1	neutral	0.18	neutral	1.78	deleterious	-11	deleterious	-6.03	high_impact	4.57	0.46	damaging	0.04	damaging	4.02	23.60	deleterious	0.02	0.35	0.91	disease	0.81	disease	0.74	disease	0.8	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.57	low_impact	-0.09	medium_impact	2.8	high_impact	0.31	0.8	59.75	9.48	0.42	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4199	4199	T	A	MI.12619	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	893	298	L	Q	cTa/cAa	-0.2	0	0	probably_damaging	1	neutral	0.2	neutral	1.79	deleterious	-10.85	deleterious	-5.2	high_impact	4.57	0.56	damaging	0.04	damaging	4.18	23.80	deleterious	0.02	0.35	0.87	disease	0.78	disease	0.64	disease	0.77	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.57	low_impact	-0.06	medium_impact	2.8	high_impact	0.29	0.8	59.75	9.48	0.39	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9118	9118	C	A	MI.1262	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	592	198	L	M	Cta/Ata	-12.6	0	0	probably_damaging	1	neutral	0.17	neutral	4.17	neutral	-2.21	neutral	-1.64	low_impact	1.48	0.92	neutral	0.85	neutral	2.69	20.70	deleterious	0.29	0.65	NA	NA	0.34	neutral	0.34	neutral	0.16	neutral	7	1	deleterious	0.09	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	-0.1	medium_impact	0.17	medium_impact	0.43	0.9	42.04	7.67	0.46	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4199	4199	T	G	MI.12620	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	893	298	L	R	cTa/cGa	-0.2	0	0	probably_damaging	1	neutral	0.25	neutral	1.79	deleterious	-10.71	deleterious	-5.21	high_impact	4.22	0.51	damaging	0.04	damaging	4.29	24.00	deleterious	0.02	0.35	0.88	disease	0.88	disease	0.75	disease	0.84	disease	7	1	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-3.57	low_impact	0.01	medium_impact	2.5	high_impact	0.13	0.8	59.75	9.48	0.37	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4201	4201	G	A	MI.12621	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	895	299	A	T	Gca/Aca	-1.81	0	0	benign	0.15	neutral	0.38	neutral	2.64	deleterious	-5.23	deleterious	-3.13	medium_impact	3.24	0.67	neutral	0.59	neutral	2.37	18.62	deleterious	0.15	0.45	0.32	neutral	0.67	disease	0.29	neutral	0.49	neutral	0	0.55	neutral	0.62	deleterious	-3	neutral	0.23	neutral	-0.04	medium_impact	0.16	medium_impact	1.64	medium_impact	0.70	0.85	56.92	10.51	0.47	N	0.70	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4201	4201	G	T	MI.12622	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	895	299	A	S	Gca/Tca	-1.81	0	0	possibly_damaging	0.78	neutral	0.42	neutral	2.65	deleterious	-5.92	neutral	-2.42	medium_impact	2.31	0.8	neutral	0.6	neutral	1.97	16.02	deleterious	0.22	0.45	0.34	neutral	0.62	disease	0.27	neutral	0.45	neutral	1	0.78	neutral	0.32	neutral	0	NA	0.59	deleterious	-1.27	low_impact	0.2	medium_impact	0.83	medium_impact	0.49	0.8	56.92	10.51	0.37	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4201	4201	G	C	MI.12623	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	895	299	A	P	Gca/Cca	-1.81	0	0	probably_damaging	0.96	neutral	0.22	neutral	2.58	deleterious	-7.92	deleterious	-4.08	high_impact	3.94	0.69	neutral	0.37	neutral	3.61	23.20	deleterious	0.05	0.35	0.58	disease	0.86	disease	0.56	disease	0.71	disease	4	0.97	neutral	0.13	neutral	2	deleterious	0.80	deleterious	-2.05	low_impact	-0.03	medium_impact	2.25	high_impact	0.56	0.8	56.92	10.51	0.43	N	0.96	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4202	4202	C	A	MI.12624	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	896	299	A	E	gCa/gAa	5.09	1	0	probably_damaging	0.93	neutral	0.2	neutral	2.64	deleterious	-8.42	deleterious	-4.1	high_impact	3.94	0.73	neutral	0.4	neutral	3.05	22.40	deleterious	0.04	0.35	0.42	neutral	0.84	disease	0.55	disease	0.72	disease	4	0.96	neutral	0.14	neutral	2	deleterious	0.73	deleterious	-1.81	low_impact	-0.06	medium_impact	2.25	high_impact	0.46	0.8	56.92	10.51	0.61	P	0.96	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4202	4202	C	T	MI.12625	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	896	299	A	V	gCa/gTa	5.09	1	0	possibly_damaging	0.78	neutral	0.48	neutral	2.66	deleterious	-6.18	deleterious	-3.07	low_impact	1.67	0.84	neutral	0.82	neutral	2.65	20.50	deleterious	0.2	0.45	0.19	neutral	0.68	disease	0.39	neutral	0.48	neutral	0	0.77	neutral	0.35	neutral	-3	neutral	0.56	deleterious	-1.27	low_impact	0.26	medium_impact	0.27	medium_impact	0.74	0.85	56.92	10.51	0.54	P	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4202	4202	C	G	MI.12626	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	896	299	A	G	gCa/gGa	5.09	1	0	possibly_damaging	0.78	neutral	0.26	neutral	2.67	deleterious	-6.68	deleterious	-3.31	medium_impact	2.08	0.74	neutral	0.6	neutral	2.20	17.52	deleterious	0.23	0.45	0.37	neutral	0.55	disease	0.25	neutral	0.45	neutral	1	0.84	neutral	0.24	neutral	0	NA	0.60	deleterious	-1.27	low_impact	0.02	medium_impact	0.63	medium_impact	0.66	0.8	56.92	10.51	0.58	P	0.79	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4204	4204	T	G	MI.12627	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	898	300	L	V	Tta/Gta	-4.81	0	0	benign	0.13	neutral	0.25	neutral	2.74	deleterious	-5.5	neutral	-2.02	low_impact	1.6	0.7	neutral	0.58	neutral	1.63	13.99	neutral	0.29	0.45	0.18	neutral	0.53	disease	0.49	neutral	0.48	neutral	0	0.71	neutral	0.56	deleterious	-6	neutral	0.19	neutral	0.02	medium_impact	0.01	medium_impact	0.21	medium_impact	0.41	0.8	24.21	11.8	0.4	N	0.33	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4204	4204	T	A	MI.12628	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	898	300	L	M	Tta/Ata	-4.81	0	0	benign	0.04	neutral	0.2	neutral	2.69	deleterious	-3.01	neutral	-0.64	low_impact	1.18	0.85	neutral	0.9	neutral	1.84	15.25	deleterious	0.23	0.45	0.26	neutral	0.17	neutral	0.23	neutral	0.29	neutral	4	0.79	neutral	0.58	deleterious	-6	neutral	0.14	neutral	0.55	medium_impact	-0.06	medium_impact	-0.16	medium_impact	0.36	0.8	24.21	11.8	0.51	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4205	4205	T	C	MI.12629	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	899	300	L	S	tTa/tCa	-2.27	0	0	benign	0.01	neutral	0.21	neutral	2.69	deleterious	-8.8	deleterious	-4.33	medium_impact	2.45	0.76	neutral	0.61	neutral	1.94	15.81	deleterious	0.09	0.4	0.29	neutral	0.67	disease	0.5	neutral	0.52	disease	0	0.79	neutral	0.6	deleterious	-3	neutral	0.19	neutral	1.12	medium_impact	-0.05	medium_impact	0.95	medium_impact	0.27	0.8	24.21	11.8	0.41	N	0.20	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9119	9119	T	A	MI.1263	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	593	198	L	Q	cTa/cAa	-4.5	0	0	probably_damaging	1	deleterious	0.01	neutral	4.13	deleterious	-3.24	deleterious	-5.19	medium_impact	2.73	0.8	neutral	0.44	neutral	4.08	23.70	deleterious	0.18	0.65	NA	NA	0.73	disease	0.58	disease	0.65	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-0.84	medium_impact	1.24	medium_impact	0.59	0.9	42.04	7.67	0.31	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4205	4205	T	G	MI.12630	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	899	300	L	W	tTa/tGa	-2.27	0	0	possibly_damaging	0.84	neutral	0.1	neutral	2.66	deleterious	-9.5	deleterious	-4.33	medium_impact	2.06	0.68	neutral	0.43	neutral	3.51	23.10	deleterious	0.07	0.35	0.32	neutral	0.72	disease	0.32	neutral	0.53	disease	1	0.95	neutral	0.13	neutral	0	NA	0.66	deleterious	-1.43	low_impact	-0.26	medium_impact	0.61	medium_impact	0.18	0.8	24.21	11.8	0.43	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4206	4206	A	C	MI.12631	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	900	300	L	F	ttA/ttC	4.63	0.67	0	benign	0.01	neutral	0.61	neutral	2.71	deleterious	-6.03	deleterious	-2.7	low_impact	0.92	0.83	neutral	0.93	neutral	0.73	9.02	deleterious	0.27	0.45	0.17	neutral	0.33	neutral	0.23	neutral	0.44	neutral	1	0.38	neutral	0.8	deleterious	-6	neutral	0.15	neutral	1.12	medium_impact	0.38	medium_impact	-0.39	medium_impact	0.40	0.8	24.21	11.8	0.39	N	0.15	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4206	4206	A	T	MI.12632	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	900	300	L	F	ttA/ttT	4.63	0.67	0	benign	0.01	neutral	0.61	neutral	2.71	deleterious	-6.03	deleterious	-2.7	low_impact	0.92	0.83	neutral	0.93	neutral	0.87	9.89	deleterious	0.27	0.45	0.17	neutral	0.33	neutral	0.23	neutral	0.44	neutral	1	0.38	neutral	0.8	deleterious	-6	neutral	0.15	neutral	1.12	medium_impact	0.38	medium_impact	-0.39	medium_impact	0.40	0.8	24.21	11.8	0.38	N	0.15	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4207	4207	C	G	MI.12633	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	901	301	L	V	Ctt/Gtt	-1.58	0	0	benign	0.32	neutral	0.35	neutral	2.63	neutral	-1.2	neutral	0.61	low_impact	0.93	0.78	neutral	0.76	neutral	1.52	13.43	neutral	0.27	0.45	0.14	neutral	0.14	neutral	0.29	neutral	0.27	neutral	5	0.58	neutral	0.52	deleterious	-6	neutral	0.25	neutral	-0.44	medium_impact	0.12	medium_impact	-0.38	medium_impact	0.57	0.8	21.7	31.14	0.43	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4207	4207	C	A	MI.12634	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	901	301	L	I	Ctt/Att	-1.58	0	0	benign	0.32	neutral	0.36	neutral	2.53	neutral	-1.47	neutral	0.53	neutral_impact	0.41	0.74	neutral	0.72	neutral	2.67	20.60	deleterious	0.3	0.45	0.18	neutral	0.34	neutral	0.27	neutral	0.45	neutral	1	0.57	neutral	0.52	deleterious	-6	neutral	0.39	neutral	-0.44	medium_impact	0.14	medium_impact	-0.83	medium_impact	0.43	0.8	21.7	31.14	0.46	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4207	4207	C	T	MI.12635	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	901	301	L	F	Ctt/Ttt	-1.58	0	0	possibly_damaging	0.85	neutral	0.65	neutral	2.44	neutral	-2.71	neutral	-0.82	low_impact	0.9	0.78	neutral	0.73	neutral	2.90	21.90	deleterious	0.2	0.45	0.32	neutral	0.47	neutral	0.35	neutral	0.47	neutral	1	0.82	neutral	0.4	neutral	-3	neutral	0.63	deleterious	-1.46	low_impact	0.43	medium_impact	-0.4	medium_impact	0.47	0.8	21.7	31.14	0.24	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4208	4208	T	A	MI.12636	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	902	301	L	H	cTt/cAt	1.18	0.85	0	probably_damaging	0.94	neutral	0.31	neutral	2.38	deleterious	-4.3	neutral	-2.44	medium_impact	3.37	0.72	neutral	0.61	neutral	4.31	24.00	deleterious	0.05	0.35	0.6	disease	0.67	disease	0.63	disease	0.72	disease	4	0.95	neutral	0.19	neutral	1	deleterious	0.74	deleterious	-1.87	low_impact	0.08	medium_impact	1.76	medium_impact	0.25	0.8	21.7	31.14	0.4	N	0.79	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4208	4208	T	G	MI.12637	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	902	301	L	R	cTt/cGt	1.18	0.85	0	probably_damaging	0.92	neutral	0.2	neutral	2.39	deleterious	-3.4	neutral	-2.42	medium_impact	3.37	0.74	neutral	0.54	neutral	4.29	24.00	deleterious	0.02	0.35	0.52	disease	0.86	disease	0.68	disease	0.8	disease	6	0.95	neutral	0.14	neutral	1	deleterious	0.80	deleterious	-1.75	low_impact	-0.06	medium_impact	1.76	medium_impact	0.22	0.8	21.7	31.14	0.39	N	0.85	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4208	4208	T	C	MI.12638	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	902	301	L	P	cTt/cCt	1.18	0.85	0	probably_damaging	0.92	neutral	0.35	neutral	2.38	deleterious	-3.35	neutral	-2.36	medium_impact	3.37	0.67	neutral	0.45	neutral	4.05	23.70	deleterious	0.02	0.35	0.6	disease	0.85	disease	0.68	disease	0.8	disease	6	0.93	neutral	0.22	neutral	1	deleterious	0.81	deleterious	-1.75	low_impact	0.12	medium_impact	1.76	medium_impact	0.34	0.8	21.7	31.14	0.36	N	0.94	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4210	4210	A	T	MI.12639	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	904	302	M	L	Ata/Tta	-6.88	0	0	probably_damaging	0.98	neutral	1	neutral	3.03	neutral	5.92	neutral	0.65	neutral_impact	-0.58	0.86	neutral	0.88	neutral	0.66	8.53	deleterious	0.18	0.45	0.14	neutral	0.29	neutral	0.3	neutral	0.43	neutral	1	0.98	deleterious	0.51	deleterious	-2	neutral	0.61	deleterious	-2.34	low_impact	1.96	high_impact	-1.7	low_impact	0.23	0.8	18.87	23.08	0.28	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9119	9119	T	C	MI.1264	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	593	198	L	P	cTa/cCa	-4.5	0	0	probably_damaging	1	deleterious	0.01	neutral	4.21	neutral	-2.97	deleterious	-6.12	medium_impact	2.73	0.77	neutral	0.4	neutral	3.93	23.50	deleterious	0.18	0.65	NA	NA	0.83	disease	0.7	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.90	deleterious	-3.6	low_impact	-0.84	medium_impact	1.24	medium_impact	0.71	0.9	42.04	7.67	0.3	N	1.00	disease_causing	0.94	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4210	4210	A	G	MI.12640	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	904	302	M	V	Ata/Gta	-6.88	0	0	probably_damaging	0.99	neutral	0.3	neutral	2.95	neutral	-0.26	neutral	-0.36	low_impact	0.94	0.8	neutral	0.25	damaging	1.59	13.80	neutral	0.18	0.45	0.1	neutral	0.55	disease	0.4	neutral	0.45	neutral	1	0.99	deleterious	0.16	neutral	-2	neutral	0.65	deleterious	-2.62	low_impact	0.07	medium_impact	-0.37	medium_impact	0.20	0.8	18.87	23.08	0.27	N	0.82	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4210	4210	A	C	MI.12641	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	904	302	M	L	Ata/Cta	-6.88	0	0	probably_damaging	0.98	neutral	1	neutral	3.03	neutral	5.92	neutral	0.65	neutral_impact	-0.58	0.86	neutral	0.88	neutral	0.55	7.82	deleterious	0.18	0.45	0.14	neutral	0.29	neutral	0.3	neutral	0.43	neutral	1	0.98	deleterious	0.51	deleterious	-2	neutral	0.61	deleterious	-2.34	low_impact	1.96	high_impact	-1.7	low_impact	0.23	0.8	18.87	23.08	0.26	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4211	4211	T	C	MI.12642	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	905	302	M	T	aTa/aCa	0.95	0.3	0	probably_damaging	1	neutral	0.49	neutral	2.81	neutral	-2.58	neutral	-2.43	low_impact	1.49	0.85	neutral	0.57	neutral	2.95	22.00	deleterious	0.09	0.35	0.22	neutral	0.53	disease	0.45	neutral	0.48	neutral	0	1	deleterious	0.25	neutral	-2	neutral	0.68	deleterious	-3.57	low_impact	0.27	medium_impact	0.11	medium_impact	0.14	0.8	18.87	23.08	0.27	N	0.90	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4211	4211	T	A	MI.12643	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	905	302	M	K	aTa/aAa	0.95	0.3	0	probably_damaging	1	neutral	0.27	neutral	2.77	deleterious	-4.1	deleterious	-3.45	medium_impact	3.13	0.62	neutral	0.11	damaging	4.02	23.60	deleterious	0.03	0.35	0.39	neutral	0.8	disease	0.67	disease	0.77	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.77	deleterious	-3.57	low_impact	0.03	medium_impact	1.55	medium_impact	0.15	0.8	18.87	23.08	0.31	N	0.95	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4212	4212	A	C	MI.12644	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	906	302	M	I	atA/atC	3.71	0.64	0	probably_damaging	0.99	neutral	0.54	neutral	2.88	neutral	0.79	neutral	0.26	neutral_impact	0.11	0.69	neutral	0.32	neutral	1.47	13.15	neutral	0.18	0.45	0.13	neutral	0.26	neutral	0.32	neutral	0.42	neutral	2	0.99	deleterious	0.28	neutral	-2	neutral	0.64	deleterious	-2.62	low_impact	0.31	medium_impact	-1.09	low_impact	0.28	0.8	18.87	23.08	0.34	N	0.87	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4212	4212	A	T	MI.12645	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	906	302	M	I	atA/atT	3.71	0.64	0	probably_damaging	0.99	neutral	0.54	neutral	2.88	neutral	0.79	neutral	0.26	neutral_impact	0.11	0.69	neutral	0.32	neutral	1.44	12.98	neutral	0.18	0.45	0.13	neutral	0.26	neutral	0.32	neutral	0.42	neutral	2	0.99	deleterious	0.28	neutral	-2	neutral	0.64	deleterious	-2.62	low_impact	0.31	medium_impact	-1.09	low_impact	0.28	0.8	18.87	23.08	0.35	N	0.87	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4213	4213	T	C	MI.12646	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	907	303	W	R	Tga/Cga	-0.43	0.28	0	probably_damaging	1	neutral	0.22	neutral	2.78	deleterious	-8.45	deleterious	-10.49	medium_impact	3.42	0.7	neutral	0.11	damaging	3.68	23.30	deleterious	0.06	0.35	0.32	neutral	0.84	disease	0.71	disease	0.77	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.76	deleterious	-3.57	low_impact	-0.03	medium_impact	1.8	medium_impact	0.17	0.8	58.81	9.14	0.36	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4213	4213	T	G	MI.12647	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	907	303	W	G	Tga/Gga	-0.43	0.28	0	probably_damaging	1	neutral	0.32	neutral	2.78	deleterious	-8.71	deleterious	-9.87	medium_impact	2.27	0.77	neutral	0.15	damaging	3.99	23.60	deleterious	0.08	0.35	0.28	neutral	0.72	disease	0.68	disease	0.7	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.70	deleterious	-3.57	low_impact	0.09	medium_impact	0.79	medium_impact	0.19	0.8	58.81	9.14	0.28	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4214	4214	G	C	MI.12648	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	908	303	W	S	tGa/tCa	1.87	0.98	0	probably_damaging	1	neutral	0.35	neutral	2.81	deleterious	-8.22	deleterious	-10.42	medium_impact	2.31	0.78	neutral	0.16	damaging	4.13	23.80	deleterious	0.09	0.35	0.2	neutral	0.77	disease	0.65	disease	0.71	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.71	deleterious	-3.57	low_impact	0.12	medium_impact	0.83	medium_impact	0.18	0.8	58.81	9.14	0.37	N	0.98	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4214	4214	G	T	MI.12649	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	908	303	W	L	tGa/tTa	1.87	0.98	0	probably_damaging	1	neutral	1	neutral	2.98	deleterious	-3.82	deleterious	-9.29	neutral_impact	0.27	0.82	neutral	0.59	neutral	3.27	22.80	deleterious	0.1	0.4	0.09	neutral	0.53	disease	0.44	neutral	0.43	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.67	deleterious	-3.57	low_impact	1.96	high_impact	-0.95	medium_impact	0.11	0.8	58.81	9.14	0.35	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9119	9119	T	G	MI.1265	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	593	198	L	R	cTa/cGa	-4.5	0	0	probably_damaging	1	deleterious	0.01	neutral	4.13	deleterious	-3.22	deleterious	-5.22	high_impact	3.82	0.79	neutral	0.39	neutral	4.17	23.80	deleterious	0.16	0.65	NA	NA	0.88	disease	0.7	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-0.84	medium_impact	2.18	high_impact	0.66	0.9	42.04	7.67	0.34	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4215	4215	A	C	MI.12650	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	909	303	W	C	tgA/tgC	1.64	0.99	0	probably_damaging	1	neutral	0.17	neutral	2.77	deleterious	-9.57	deleterious	-9.56	low_impact	1.68	0.78	neutral	0.11	damaging	4.15	23.80	deleterious	0.09	0.35	0.41	neutral	0.8	disease	0.63	disease	0.71	disease	4	1	deleterious	0.09	neutral	-2	neutral	0.72	deleterious	-3.57	low_impact	-0.11	medium_impact	0.28	medium_impact	0.16	0.8	58.81	9.14	0.34	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4215	4215	A	T	MI.12651	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	909	303	W	C	tgA/tgT	1.64	0.99	0	probably_damaging	1	neutral	0.17	neutral	2.77	deleterious	-9.57	deleterious	-9.56	low_impact	1.68	0.78	neutral	0.11	damaging	4.22	23.90	deleterious	0.09	0.35	0.41	neutral	0.8	disease	0.63	disease	0.71	disease	4	1	deleterious	0.09	neutral	-2	neutral	0.72	deleterious	-3.57	low_impact	-0.11	medium_impact	0.28	medium_impact	0.16	0.8	58.81	9.14	0.35	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4216	4216	T	C	MI.12652	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	910	304	Y	H	Tat/Cat	2.56	0.98	0.22	benign	0.01	neutral	0.37	neutral	2.8	neutral	2.95	neutral	3.51	neutral_impact	-1.19	0.33	damaging	0.97	neutral	-0.95	0.02	neutral	0.15	0.4	0.11	neutral	0.1	neutral	0.3	neutral	0.22	neutral	6	0.62	neutral	0.68	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.15	medium_impact	-2.23	low_impact	0.30	0.8	29.25	30	0.73	P	0.03	polymorphism	1	0.01	rs1599988	Conflicting_interpretations_of_pathogenicity	Leber's_optic_atrophy	24763	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	acute leukemia platelets, leukocytes & bone marrow	COSM1138371	.	.	T4216C	LHON / Insulin Resistance /possible adaptive high altitude variant	+	-	Reported / Population-dependent	38	N	N	N	neutral
chrM	4216	4216	T	A	MI.12653	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	910	304	Y	N	Tat/Aat	2.56	0.98	0.22	benign	0.02	neutral	0.15	neutral	2.77	deleterious	-4.94	neutral	-1.66	neutral_impact	0.77	0.79	neutral	0.86	neutral	2.22	17.64	deleterious	0.15	0.4	0.24	neutral	0.6	disease	0.39	neutral	0.46	neutral	1	0.85	neutral	0.57	deleterious	-6	neutral	0.17	neutral	0.84	medium_impact	-0.15	medium_impact	-0.52	medium_impact	0.28	0.8	29.25	30	0.52	N	0.47	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4216	4216	T	G	MI.12654	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	910	304	Y	D	Tat/Gat	2.56	0.98	0.22	benign	0.36	neutral	0.08	neutral	2.76	deleterious	-5.99	deleterious	-3.26	medium_impact	2.21	0.74	neutral	0.41	neutral	2.27	18.00	deleterious	0.08	0.35	0.29	neutral	0.8	disease	0.6	disease	0.77	disease	5	0.91	neutral	0.36	neutral	-3	neutral	0.30	neutral	-0.52	medium_impact	-0.32	medium_impact	0.74	medium_impact	0.26	0.8	29.25	30	0.51	N	0.68	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4217	4217	A	C	MI.12655	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	911	304	Y	S	tAt/tCt	-0.2	0.76	0	benign	0.03	neutral	0.21	neutral	2.8	deleterious	-4.78	deleterious	-3.12	neutral_impact	0.37	0.73	neutral	0.83	neutral	1.90	15.58	deleterious	0.09	0.35	0.15	neutral	0.63	disease	0.48	neutral	0.5	disease	0	0.78	neutral	0.59	deleterious	-6	neutral	0.16	neutral	0.67	medium_impact	-0.05	medium_impact	-0.87	medium_impact	0.29	0.8	29.25	30	0.36	N	0.07	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4217	4217	A	T	MI.12656	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	911	304	Y	F	tAt/tTt	-0.2	0.76	0	possibly_damaging	0.52	neutral	0.55	neutral	2.84	neutral	-0.44	deleterious	-2.54	neutral_impact	-0.22	0.82	neutral	0.96	neutral	1.50	13.32	neutral	0.25	0.45	0.14	neutral	0.38	neutral	0.26	neutral	0.43	neutral	1	0.48	neutral	0.52	deleterious	-3	neutral	0.31	neutral	-0.78	medium_impact	0.32	medium_impact	-1.38	low_impact	0.42	0.8	29.25	30	0.25	N	0.09	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4217	4217	A	G	MI.12657	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	911	304	Y	C	tAt/tGt	-0.2	0.76	0	possibly_damaging	0.89	neutral	0.17	neutral	2.75	deleterious	-6.38	deleterious	-4.6	low_impact	1.52	0.83	neutral	0.47	neutral	3.27	22.80	deleterious	0.08	0.35	0.34	neutral	0.76	disease	0.51	disease	0.62	disease	2	0.94	neutral	0.14	neutral	-3	neutral	0.67	deleterious	-1.6	low_impact	-0.11	medium_impact	0.14	medium_impact	0.08	0.8	29.25	30	0.39	N	0.66	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4219	4219	G	T	MI.12658	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	913	305	V	F	Gtc/Ttc	-5.5	0	0	benign	0.16	neutral	0.43	neutral	2.7	deleterious	-3	neutral	-1.95	neutral_impact	0.65	0.76	neutral	0.63	neutral	1.95	15.88	deleterious	0.06	0.35	0.27	neutral	0.63	disease	0.25	neutral	0.43	neutral	1	0.49	neutral	0.64	deleterious	-6	neutral	0.16	neutral	-0.08	medium_impact	0.21	medium_impact	-0.62	medium_impact	0.36	0.8	23.27	23.47	0.36	N	0.65	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4219	4219	G	C	MI.12659	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	913	305	V	L	Gtc/Ctc	-5.5	0	0	benign	0	neutral	1	neutral	2.77	neutral	-1.49	neutral	0.01	neutral_impact	0.38	0.81	neutral	0.67	neutral	-0.55	0.16	neutral	0.22	0.45	0.14	neutral	0.23	neutral	0.2	neutral	0.4	neutral	2	0	neutral	1	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	1.96	high_impact	-0.86	medium_impact	0.52	0.8	23.27	23.47	0.3	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9121	9121	C	A	MI.1266	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	595	199	L	M	Ctg/Atg	-6.58	0	0	probably_damaging	1	deleterious	0.02	neutral	4.06	neutral	-1.13	neutral	-1.76	medium_impact	2.37	0.54	damaging	0.12	damaging	3.89	23.50	deleterious	0.34	0.65	NA	NA	0.48	neutral	0.53	disease	0.4	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.6	low_impact	-0.66	medium_impact	0.93	medium_impact	0.59	0.9	50	8.81	0.3	N	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4219	4219	G	A	MI.12660	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	913	305	V	I	Gtc/Atc	-5.5	0	0	benign	0	neutral	0.48	neutral	2.81	neutral	-0.42	neutral	0.24	neutral_impact	-1.02	0.73	neutral	0.94	neutral	-0.86	0.03	neutral	0.35	0.5	0.11	neutral	0.1	neutral	0.17	neutral	0.26	neutral	5	0.52	neutral	0.74	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.26	medium_impact	-2.08	low_impact	0.77	0.85	23.27	23.47	0.42	N	0.03	polymorphism	1	0.01	rs878853008	Likely_benign	not_provided	237002	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4220	4220	T	A	MI.12661	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	914	305	V	D	gTc/gAc	0.03	0	0	benign	0.21	neutral	0.06	neutral	2.7	deleterious	-4.11	deleterious	-3.92	medium_impact	2.21	0.77	neutral	0.44	neutral	2.67	20.60	deleterious	0.02	0.35	0.44	neutral	0.73	disease	0.6	disease	0.73	disease	5	0.93	neutral	0.43	neutral	-3	neutral	0.24	neutral	-0.21	medium_impact	-0.4	medium_impact	0.74	medium_impact	0.10	0.8	23.27	23.47	0.34	N	0.84	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4220	4220	T	G	MI.12662	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	914	305	V	G	gTc/gGc	0.03	0	0	benign	0.1	neutral	0.16	neutral	2.7	deleterious	-3.26	deleterious	-4.34	neutral_impact	0.14	0.73	neutral	0.46	neutral	2.01	16.27	deleterious	0.05	0.35	0.28	neutral	0.53	disease	0.42	neutral	0.5	neutral	0	0.82	neutral	0.53	deleterious	-6	neutral	0.15	neutral	0.15	medium_impact	-0.13	medium_impact	-1.07	low_impact	0.24	0.8	23.27	23.47	0.38	N	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4220	4220	T	C	MI.12663	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	914	305	V	A	gTc/gCc	0.03	0	0	benign	0	neutral	0.51	neutral	2.88	neutral	-1.35	neutral	-2.01	neutral_impact	-0.3	0.82	neutral	0.73	neutral	0.56	7.90	deleterious	0.16	0.45	0.13	neutral	0.27	neutral	0.39	neutral	0.42	neutral	2	0.49	neutral	0.76	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.29	medium_impact	-1.45	low_impact	0.31	0.8	23.27	23.47	0.3	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4222	4222	T	C	MI.12664	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	916	306	S	P	Tcc/Ccc	-11.71	0	0	probably_damaging	0.93	neutral	0.21	neutral	2.65	deleterious	-5.25	deleterious	-3.33	medium_impact	3.11	0.61	neutral	0.37	neutral	4.05	23.70	deleterious	0.05	0.35	0.45	neutral	0.85	disease	0.71	disease	0.77	disease	5	0.95	neutral	0.14	neutral	1	deleterious	0.78	deleterious	-1.81	low_impact	-0.05	medium_impact	1.53	medium_impact	0.37	0.8	54.72	12.76	0.28	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4222	4222	T	A	MI.12665	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	916	306	S	T	Tcc/Acc	-11.71	0	0	benign	0.08	neutral	0.38	neutral	2.72	neutral	-1.43	neutral	-1.67	low_impact	1.41	0.88	neutral	0.98	neutral	2.57	19.91	deleterious	0.17	0.45	0.25	neutral	0.4	neutral	0.37	neutral	0.44	neutral	1	0.57	neutral	0.65	deleterious	-6	neutral	0.17	neutral	0.25	medium_impact	0.16	medium_impact	0.04	medium_impact	0.58	0.8	54.72	12.76	0.41	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4222	4222	T	G	MI.12666	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	916	306	S	A	Tcc/Gcc	-11.71	0	0	benign	0.05	neutral	0.44	neutral	2.78	neutral	-1.68	neutral	-1.07	neutral_impact	0.8	0.87	neutral	0.98	neutral	1.98	16.08	deleterious	0.21	0.45	0.15	neutral	0.19	neutral	0.34	neutral	0.34	neutral	3	0.52	neutral	0.7	deleterious	-6	neutral	0.14	neutral	0.45	medium_impact	0.22	medium_impact	-0.49	medium_impact	0.54	0.8	54.72	12.76	0.41	N	0.17	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4223	4223	C	A	MI.12667	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	917	306	S	Y	tCc/tAc	0.26	0	0	probably_damaging	0.95	neutral	0.7	neutral	2.66	deleterious	-5.38	deleterious	-4.05	medium_impact	2.42	0.71	neutral	0.46	neutral	4.18	23.80	deleterious	0.06	0.35	0.54	disease	0.77	disease	0.53	disease	0.66	disease	3	0.94	neutral	0.38	neutral	1	deleterious	0.75	deleterious	-1.95	low_impact	0.48	medium_impact	0.93	medium_impact	0.33	0.8	54.72	12.76	0.24	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4223	4223	C	G	MI.12668	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	917	306	S	C	tCc/tGc	0.26	0	0	probably_damaging	0.96	neutral	0.16	neutral	2.65	deleterious	-5.91	deleterious	-3.05	medium_impact	2.17	0.62	neutral	0.39	neutral	3.66	23.20	deleterious	0.07	0.35	0.56	disease	0.72	disease	0.4	neutral	0.52	disease	0	0.98	deleterious	0.1	neutral	1	deleterious	0.73	deleterious	-2.05	low_impact	-0.13	medium_impact	0.71	medium_impact	0.47	0.8	54.72	12.76	0.39	N	0.54	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4223	4223	C	T	MI.12669	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	917	306	S	F	tCc/tTc	0.26	0	0	possibly_damaging	0.87	neutral	0.65	neutral	2.69	deleterious	-5.13	deleterious	-4.01	medium_impact	2.07	0.65	neutral	0.44	neutral	4.36	24.10	deleterious	0.05	0.35	0.51	disease	0.81	disease	0.52	disease	0.7	disease	4	0.85	neutral	0.39	neutral	0	NA	0.71	deleterious	-1.53	low_impact	0.43	medium_impact	0.62	medium_impact	0.23	0.8	54.72	12.76	0.26	N	1.00	polymorphism	1	0.09	rs9629043	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9121	9121	C	G	MI.1267	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	595	199	L	V	Ctg/Gtg	-6.58	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.18	neutral	-1.5	deleterious	-2.66	medium_impact	2.9	0.45	damaging	0.09	damaging	3.57	23.10	deleterious	0.33	0.65	NA	NA	0.59	disease	0.63	disease	0.57	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-2.65	low_impact	-0.84	medium_impact	1.39	medium_impact	0.43	0.9	50	8.81	0.29	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4225	4225	A	G	MI.12670	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	919	307	M	V	Ata/Gta	-5.96	0	0	benign	0	neutral	0.48	neutral	2.96	neutral	-2.09	neutral	-0.9	low_impact	0.93	0.88	neutral	0.87	neutral	-0.07	1.99	neutral	0.26	0.45	0.07	neutral	0.5	disease	0.41	neutral	0.45	neutral	1	0.52	neutral	0.74	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.26	medium_impact	-0.38	medium_impact	0.30	0.8	27.99	23.94	0.32	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4225	4225	A	T	MI.12671	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	919	307	M	L	Ata/Tta	-5.96	0	0	benign	0	neutral	1	neutral	3.23	neutral	2.94	neutral	0.56	neutral_impact	-0.64	0.73	neutral	0.99	neutral	-1.04	0.01	neutral	0.3	0.45	0.14	neutral	0.2	neutral	0.33	neutral	0.33	neutral	4	0	neutral	1	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	1.96	high_impact	-1.75	low_impact	0.19	0.8	27.99	23.94	0.36	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4225	4225	A	C	MI.12672	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	919	307	M	L	Ata/Cta	-5.96	0	0	benign	0	neutral	1	neutral	3.23	neutral	2.94	neutral	0.56	neutral_impact	-0.64	0.73	neutral	0.99	neutral	-1.18	0.01	neutral	0.3	0.45	0.14	neutral	0.2	neutral	0.33	neutral	0.33	neutral	4	0	neutral	1	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	1.96	high_impact	-1.75	low_impact	0.19	0.8	27.99	23.94	0.36	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4226	4226	T	A	MI.12673	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	920	307	M	K	aTa/aAa	-1.81	0	0	benign	0.04	neutral	0.17	neutral	2.73	deleterious	-5.61	deleterious	-3.43	medium_impact	2.79	0.69	neutral	0.41	neutral	2.12	17.00	deleterious	0.04	0.35	0.42	neutral	0.72	disease	0.66	disease	0.75	disease	5	0.82	neutral	0.57	deleterious	-3	neutral	0.24	neutral	0.55	medium_impact	-0.11	medium_impact	1.25	medium_impact	0.13	0.8	27.99	23.94	0.38	N	0.80	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4226	4226	T	C	MI.12674	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	920	307	M	T	aTa/aCa	-1.81	0	0	benign	0	neutral	0.18	neutral	2.76	deleterious	-4.08	neutral	-2.49	low_impact	1.34	0.83	neutral	0.96	neutral	0.00	2.59	deleterious	0.13	0.4	0.26	neutral	0.45	neutral	0.42	neutral	0.46	neutral	1	0.82	neutral	0.59	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	-0.09	medium_impact	-0.02	medium_impact	0.12	0.8	27.99	23.94	0.43	N	0.41	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4227	4227	A	T	MI.12675	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	921	307	M	I	atA/atT	3.02	0.61	0	benign	0	neutral	0.52	neutral	2.93	neutral	-0.74	neutral	-0.37	neutral_impact	0.74	0.88	neutral	0.99	neutral	0.45	7.05	deleterious	0.3	0.45	0.1	neutral	0.47	neutral	0.37	neutral	0.44	neutral	1	0.48	neutral	0.76	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.29	medium_impact	-0.54	medium_impact	0.30	0.8	27.99	23.94	0.34	N	0.05	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4227	4227	A	C	MI.12676	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	921	307	M	I	atA/atC	3.02	0.61	0	benign	0	neutral	0.52	neutral	2.93	neutral	-0.74	neutral	-0.37	neutral_impact	0.74	0.88	neutral	0.99	neutral	0.36	6.30	deleterious	0.3	0.45	0.1	neutral	0.47	neutral	0.37	neutral	0.44	neutral	1	0.48	neutral	0.76	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.29	medium_impact	-0.54	medium_impact	0.30	0.8	27.99	23.94	0.34	N	0.05	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4228	4228	C	A	MI.12677	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	922	308	P	T	Ccc/Acc	-10.33	0	0	possibly_damaging	0.75	neutral	0.4	neutral	2.82	deleterious	-8.83	deleterious	-6.32	medium_impact	2.29	0.79	neutral	0.54	neutral	1.88	15.44	deleterious	0.19	0.45	0.13	neutral	0.63	disease	0.36	neutral	0.46	neutral	1	0.76	neutral	0.33	neutral	0	NA	0.48	deleterious	-1.2	low_impact	0.18	medium_impact	0.81	medium_impact	0.51	0.8	25.16	10.14	0.31	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4228	4228	C	T	MI.12678	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	922	308	P	S	Ccc/Tcc	-10.33	0	0	benign	0.18	neutral	0.46	neutral	2.84	deleterious	-8.39	deleterious	-6.32	medium_impact	2.21	0.74	neutral	0.65	neutral	0.96	10.40	neutral	0.22	0.45	0.09	neutral	0.59	disease	0.35	neutral	0.44	neutral	1	0.45	neutral	0.64	deleterious	-3	neutral	0.19	neutral	-0.13	medium_impact	0.24	medium_impact	0.74	medium_impact	0.20	0.8	25.16	10.14	0.36	N	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4228	4228	C	G	MI.12679	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	922	308	P	A	Ccc/Gcc	-10.33	0	0	possibly_damaging	0.51	neutral	0.53	neutral	2.88	deleterious	-8.09	deleterious	-6.32	medium_impact	2.55	0.76	neutral	0.55	neutral	1.26	12.07	neutral	0.2	0.45	0.09	neutral	0.51	disease	0.48	neutral	0.46	neutral	1	0.49	neutral	0.51	deleterious	0	NA	0.38	neutral	-0.77	medium_impact	0.3	medium_impact	1.04	medium_impact	0.58	0.8	25.16	10.14	0.33	N	0.75	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9122	9122	T	G	MI.1268	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	596	199	L	R	cTg/cGg	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	4.04	deleterious	-4.11	deleterious	-5.32	high_impact	4.28	0.46	damaging	0.07	damaging	4.26	23.90	deleterious	0.16	0.65	NA	NA	0.88	disease	0.75	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.6	low_impact	-1.4	low_impact	2.57	high_impact	0.39	0.9	50	8.81	0.47	N	0.99	disease_causing	0.83	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4229	4229	C	A	MI.12680	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	923	308	P	H	cCc/cAc	2.79	0.86	0	probably_damaging	0.96	neutral	0.55	neutral	2.77	deleterious	-10.66	deleterious	-7.21	medium_impact	3.18	0.75	neutral	0.39	neutral	3.95	23.60	deleterious	0.1	0.4	0.23	neutral	0.75	disease	0.68	disease	0.69	disease	4	0.96	neutral	0.3	neutral	1	deleterious	0.71	deleterious	-2.05	low_impact	0.32	medium_impact	1.59	medium_impact	0.33	0.8	25.16	10.14	0.41	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4229	4229	C	T	MI.12681	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	923	308	P	L	cCc/cTc	2.79	0.86	0	benign	0.11	neutral	0.83	neutral	2.87	deleterious	-7.2	deleterious	-7.87	low_impact	1.51	0.82	neutral	0.62	neutral	2.52	19.60	deleterious	0.16	0.45	0.13	neutral	0.69	disease	0.35	neutral	0.5	disease	0	0.07	neutral	0.86	deleterious	-6	neutral	0.18	neutral	0.1	medium_impact	0.66	medium_impact	0.13	medium_impact	0.52	0.8	25.16	10.14	0.32	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4229	4229	C	G	MI.12682	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	923	308	P	R	cCc/cGc	2.79	0.86	0	probably_damaging	0.9	neutral	0.34	neutral	2.81	deleterious	-9.51	deleterious	-7.19	medium_impact	2.98	0.74	neutral	0.45	neutral	1.91	15.67	deleterious	0.09	0.35	0.12	neutral	0.83	disease	0.65	disease	0.72	disease	4	0.91	neutral	0.22	neutral	1	deleterious	0.68	deleterious	-1.65	low_impact	0.11	medium_impact	1.41	medium_impact	0.39	0.8	25.16	10.14	0.39	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4231	4231	A	G	MI.12683	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	925	309	I	V	Att/Gtt	-6.19	0	0	benign	0	neutral	0.59	neutral	2.78	neutral	-1.72	neutral	-0.46	low_impact	1.84	0.87	neutral	0.96	neutral	0.04	2.93	deleterious	0.37	0.5	0.08	neutral	0.18	neutral	0.32	neutral	0.3	neutral	4	0.4	neutral	0.8	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.36	medium_impact	0.42	medium_impact	0.31	0.8	19.81	12.09	0.35	N	0.52	polymorphism	1	0.01	rs878929819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4231	4231	A	C	MI.12684	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	925	309	I	L	Att/Ctt	-6.19	0	0	benign	0.01	neutral	0.96	neutral	2.79	neutral	-1.86	neutral	-0.99	medium_impact	2.04	0.76	neutral	0.63	neutral	0.79	9.38	deleterious	0.28	0.45	0.15	neutral	0.29	neutral	0.27	neutral	0.43	neutral	1	0.01	neutral	0.98	deleterious	-3	neutral	0.11	neutral	1.12	medium_impact	1.05	medium_impact	0.59	medium_impact	0.53	0.8	19.81	12.09	0.33	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4231	4231	A	T	MI.12685	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	925	309	I	F	Att/Ttt	-6.19	0	0	benign	0.16	neutral	0.8	neutral	2.64	deleterious	-3.87	deleterious	-2.72	medium_impact	2.74	0.83	neutral	0.46	neutral	2.20	17.52	deleterious	0.22	0.45	0.36	neutral	0.6	disease	0.38	neutral	0.49	neutral	0	0.1	neutral	0.82	deleterious	-3	neutral	0.29	neutral	-0.08	medium_impact	0.61	medium_impact	1.2	medium_impact	0.45	0.8	19.81	12.09	0.22	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4232	4232	T	C	MI.12686	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	926	309	I	T	aTt/aCt	2.33	0.12	0.01	benign	0	neutral	0.43	neutral	2.67	neutral	-1.2	deleterious	-2.56	low_impact	1.84	0.83	neutral	0.86	neutral	0.25	5.16	deleterious	0.17	0.45	0.22	neutral	0.35	neutral	0.39	neutral	0.44	neutral	1	0.57	neutral	0.72	deleterious	-6	neutral	0.15	neutral	2.07	high_impact	0.21	medium_impact	0.42	medium_impact	0.20	0.8	19.81	12.09	0.44	N	0.39	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4232	4232	T	A	MI.12687	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	926	309	I	N	aTt/aAt	2.33	0.12	0.01	benign	0.16	neutral	0.45	neutral	2.61	deleterious	-4.97	deleterious	-4.59	medium_impact	3.29	0.72	neutral	0.44	neutral	2.54	19.72	deleterious	0.12	0.4	0.5	neutral	0.67	disease	0.59	disease	0.68	disease	4	0.46	neutral	0.65	deleterious	-3	neutral	0.33	neutral	-0.08	medium_impact	0.23	medium_impact	1.69	medium_impact	0.17	0.8	19.81	12.09	0.38	N	0.87	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4232	4232	T	G	MI.12688	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	926	309	I	S	aTt/aGt	2.33	0.12	0.01	benign	0.06	neutral	0.43	neutral	2.65	deleterious	-3.54	deleterious	-3.74	medium_impact	2.74	0.74	neutral	0.49	neutral	2.43	18.99	deleterious	0.05	0.35	0.34	neutral	0.69	disease	0.58	disease	0.64	disease	3	0.52	neutral	0.69	deleterious	-3	neutral	0.22	neutral	0.37	medium_impact	0.21	medium_impact	1.2	medium_impact	0.15	0.8	19.81	12.09	0.4	N	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4233	4233	T	A	MI.12689	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	927	309	I	M	atT/atA	1.41	0.12	0	benign	0.02	neutral	0.32	neutral	2.64	deleterious	-3.37	neutral	-1.59	low_impact	1.94	0.87	neutral	0.93	neutral	0.80	9.49	deleterious	0.35	0.5	0.33	neutral	0.31	neutral	0.32	neutral	0.47	neutral	1	0.66	neutral	0.65	deleterious	-6	neutral	0.14	neutral	0.84	medium_impact	0.09	medium_impact	0.51	medium_impact	0.51	0.8	19.81	12.09	0.49	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9122	9122	T	C	MI.1269	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	596	199	L	P	cTg/cCg	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	4.03	deleterious	-4.53	deleterious	-6.24	high_impact	3.94	0.39	damaging	0.07	damaging	4.03	23.70	deleterious	0.17	0.65	NA	NA	0.82	disease	0.74	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.28	high_impact	0.56	0.9	50	8.81	0.48	N	1.00	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4233	4233	T	G	MI.12690	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	927	309	I	M	atT/atG	1.41	0.12	0	benign	0.02	neutral	0.32	neutral	2.64	deleterious	-3.37	neutral	-1.59	low_impact	1.94	0.87	neutral	0.93	neutral	0.51	7.53	deleterious	0.35	0.5	0.33	neutral	0.31	neutral	0.32	neutral	0.47	neutral	1	0.66	neutral	0.65	deleterious	-6	neutral	0.14	neutral	0.84	medium_impact	0.09	medium_impact	0.51	medium_impact	0.51	0.8	19.81	12.09	0.49	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4234	4234	A	T	MI.12691	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	928	310	T	S	Aca/Tca	-6.19	0	0.01	benign	0	neutral	0.43	neutral	2.82	neutral	4.01	neutral	0.32	neutral_impact	-1.38	0.84	neutral	0.98	neutral	-0.59	0.13	neutral	0.34	0.5	0.11	neutral	0.07	neutral	0.21	neutral	0.29	neutral	4	0.57	neutral	0.72	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	0.21	medium_impact	-2.39	low_impact	0.58	0.8	24.84	23.47	0.44	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4234	4234	A	G	MI.12692	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	928	310	T	A	Aca/Gca	-6.19	0	0.01	benign	0	neutral	0.54	neutral	2.84	neutral	0.14	neutral	0.59	neutral_impact	-0.5	0.89	neutral	0.97	neutral	-1.11	0.01	neutral	0.25	0.45	0.09	neutral	0.06	neutral	0.24	neutral	0.19	neutral	6	0.46	neutral	0.77	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.31	medium_impact	-1.63	low_impact	0.29	0.8	24.84	23.47	0.42	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4234	4234	A	C	MI.12693	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	928	310	T	P	Aca/Cca	-6.19	0	0.01	benign	0.09	neutral	0.25	neutral	2.73	neutral	-2.9	neutral	-1.84	medium_impact	2.31	0.66	neutral	0.4	neutral	1.58	13.76	neutral	0.1	0.4	0.27	neutral	0.62	disease	0.59	disease	0.74	disease	5	0.72	neutral	0.58	deleterious	-3	neutral	0.20	neutral	0.19	medium_impact	0.01	medium_impact	0.83	medium_impact	0.43	0.8	24.84	23.47	0.41	N	0.25	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4235	4235	C	A	MI.12694	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	929	310	T	K	aCa/aAa	-1.81	0	0	benign	0.03	neutral	0.31	neutral	2.79	neutral	-2.25	neutral	-1.51	medium_impact	2.31	0.69	neutral	0.51	neutral	2.45	19.12	deleterious	0.12	0.4	0.15	neutral	0.43	neutral	0.56	disease	0.5	neutral	0	0.67	neutral	0.64	deleterious	-3	neutral	0.12	neutral	0.67	medium_impact	0.08	medium_impact	0.83	medium_impact	0.40	0.8	24.84	23.47	0.44	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4235	4235	C	T	MI.12695	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	929	310	T	M	aCa/aTa	-1.81	0	0	benign	0	neutral	0.32	neutral	2.76	neutral	-1.7	neutral	-0.89	neutral_impact	0.08	0.87	neutral	0.91	neutral	0.57	7.97	deleterious	0.19	0.45	0.12	neutral	0.17	neutral	0.3	neutral	0.31	neutral	4	0.68	neutral	0.66	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.09	medium_impact	-1.12	low_impact	0.40	0.8	24.84	23.47	0.41	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4237	4237	A	C	MI.12696	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	931	311	I	L	Atc/Ctc	-2.5	0	0	benign	0	neutral	1	neutral	2.9	neutral	0.52	neutral	0.8	neutral_impact	-1.73	0.83	neutral	0.92	neutral	-0.75	0.06	neutral	0.28	0.45	0.05	neutral	0.05	neutral	0.27	neutral	0.16	neutral	7	0	neutral	1	deleterious	-6	neutral	0.04	neutral	2.07	high_impact	1.96	high_impact	-2.7	low_impact	0.57	0.8	19.81	19	0.34	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4237	4237	A	T	MI.12697	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	931	311	I	F	Atc/Ttc	-2.5	0	0	benign	0.05	neutral	0.9	neutral	2.75	neutral	-1.8	neutral	-0.18	neutral_impact	-0.57	0.84	neutral	0.88	neutral	0.19	4.53	deleterious	0.18	0.45	0.12	neutral	0.09	neutral	0.34	neutral	0.28	neutral	4	0.03	neutral	0.93	deleterious	-6	neutral	0.10	neutral	0.45	medium_impact	0.81	medium_impact	-1.69	low_impact	0.62	0.8	19.81	19	0.29	N	0.43	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4237	4237	A	G	MI.12698	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	931	311	I	V	Atc/Gtc	-2.5	0	0	benign	0.01	neutral	0.59	neutral	2.81	neutral	-0.36	neutral	-0.43	low_impact	0.99	0.87	neutral	0.75	neutral	1.21	11.82	neutral	0.34	0.5	0.08	neutral	0.08	neutral	0.37	neutral	0.3	neutral	4	0.39	neutral	0.79	deleterious	-6	neutral	0.06	neutral	1.12	medium_impact	0.36	medium_impact	-0.32	medium_impact	0.37	0.8	19.81	19	0.37	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4238	4238	T	A	MI.12699	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	932	311	I	N	aTc/aAc	-3.88	0	0	benign	0.05	neutral	0.32	neutral	2.68	neutral	-2.87	deleterious	-2.89	low_impact	1.45	0.74	neutral	0.57	neutral	2.75	21.10	deleterious	0.14	0.4	0.31	neutral	0.33	neutral	0.62	disease	0.48	neutral	0	0.65	neutral	0.64	deleterious	-6	neutral	0.18	neutral	0.45	medium_impact	0.09	medium_impact	0.08	medium_impact	0.20	0.8	19.81	19	0.41	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8585	8585	C	A	MI.127	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	59	20	A	E	gCa/gAa	-1.49	0	0	possibly_damaging	0.6	neutral	0.27	neutral	4.6	neutral	-1.26	neutral	-2.31	low_impact	1.45	0.93	neutral	0.56	neutral	3.84	23.40	deleterious	0.16	0.65	0.69	disease	0.7	disease	0.58	disease	0.73	disease	5	0.74	neutral	0.34	neutral	-3	neutral	0.54	deleterious	-0.92	medium_impact	0.05	medium_impact	0.15	medium_impact	0.59	0.9	24.78	23.03	0.35	N	0.71	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9122	9122	T	A	MI.1270	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	596	199	L	Q	cTg/cAg	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	4.04	deleterious	-4.22	deleterious	-5.32	high_impact	4.28	0.48	damaging	0.07	damaging	4.35	24.10	deleterious	0.19	0.65	NA	NA	0.74	disease	0.63	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.57	high_impact	0.50	0.9	50	8.81	0.37	N	0.98	disease_causing	0.79	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4238	4238	T	C	MI.12700	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	932	311	I	T	aTc/aCc	-3.88	0	0	benign	0	neutral	0.57	neutral	2.73	neutral	1.18	neutral	-1.32	neutral_impact	-0.74	0.83	neutral	0.91	neutral	0.03	2.91	deleterious	0.19	0.45	0.11	neutral	0.1	neutral	0.4	neutral	0.31	neutral	4	0.43	neutral	0.79	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.34	medium_impact	-1.83	low_impact	0.33	0.8	19.81	19	0.34	N	0.07	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4238	4238	T	G	MI.12701	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	932	311	I	S	aTc/aGc	-3.88	0	0	benign	0	neutral	0.54	neutral	2.71	neutral	-1.44	neutral	-2.02	neutral_impact	0.48	0.84	neutral	0.96	neutral	2.35	18.47	deleterious	0.09	0.35	0.19	neutral	0.29	neutral	0.52	disease	0.45	neutral	1	0.45	neutral	0.77	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.31	medium_impact	-0.77	medium_impact	0.24	0.8	19.81	19	0.3	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4239	4239	C	A	MI.12702	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	933	311	I	M	atC/atA	0.03	0	0	benign	0	neutral	0.27	neutral	2.72	neutral	1.59	neutral	0.6	neutral_impact	-1.27	0.88	neutral	0.9	neutral	0.28	5.47	deleterious	0.33	0.5	0.12	neutral	0.05	neutral	0.31	neutral	0.25	neutral	5	0.73	neutral	0.64	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.03	medium_impact	-2.3	low_impact	0.48	0.8	19.81	19	0.45	N	0.59	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4239	4239	C	G	MI.12703	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	933	311	I	M	atC/atG	0.03	0	0	benign	0	neutral	0.27	neutral	2.72	neutral	1.59	neutral	0.6	neutral_impact	-1.27	0.88	neutral	0.9	neutral	-0.13	1.55	neutral	0.33	0.5	0.12	neutral	0.05	neutral	0.31	neutral	0.25	neutral	5	0.73	neutral	0.64	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.03	medium_impact	-2.3	low_impact	0.48	0.8	19.81	19	0.44	N	0.59	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4240	4240	T	A	MI.12704	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	934	312	S	T	Tcc/Acc	-3.19	0	0	benign	0.11	neutral	0.49	neutral	2.78	neutral	-0.77	neutral	-1.22	low_impact	1.12	0.85	neutral	0.75	neutral	0.80	9.46	deleterious	0.34	0.5	0.09	neutral	0.12	neutral	0.29	neutral	0.29	neutral	4	0.43	neutral	0.69	deleterious	-6	neutral	0.11	neutral	0.1	medium_impact	0.27	medium_impact	-0.21	medium_impact	0.41	0.8	13.84	15.43	0.37	N	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4240	4240	T	C	MI.12705	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	934	312	S	P	Tcc/Ccc	-3.19	0	0	benign	0.4	neutral	0.24	neutral	2.72	neutral	-2.58	deleterious	-2.61	medium_impact	3.17	0.66	neutral	0.33	neutral	2.12	16.99	deleterious	0.19	0.45	0.19	neutral	0.54	disease	0.61	disease	0.71	disease	4	0.72	neutral	0.42	neutral	-3	neutral	0.41	neutral	-0.59	medium_impact	-0.01	medium_impact	1.58	medium_impact	0.20	0.8	13.84	15.43	0.38	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4240	4240	T	G	MI.12706	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	934	312	S	A	Tcc/Gcc	-3.19	0	0	benign	0	neutral	0.68	neutral	2.83	neutral	0.26	neutral	0.06	neutral_impact	-0.16	0.88	neutral	0.98	neutral	-0.91	0.03	neutral	0.33	0.5	0.05	neutral	0.03	neutral	0.23	neutral	0.19	neutral	6	0.31	neutral	0.84	deleterious	-6	neutral	0.04	neutral	2.07	high_impact	0.46	medium_impact	-1.33	low_impact	0.26	0.8	13.84	15.43	0.41	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4241	4241	C	G	MI.12707	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	935	312	S	C	tCc/tGc	-0.43	0	0	benign	0.01	neutral	0.17	neutral	2.7	neutral	-2.52	neutral	-2.06	medium_impact	2.48	0.92	neutral	0.78	neutral	1.83	15.16	deleterious	0.21	0.45	0.31	neutral	0.3	neutral	0.35	neutral	0.46	neutral	1	0.83	neutral	0.58	deleterious	-3	neutral	0.09	neutral	1.12	medium_impact	-0.11	medium_impact	0.98	medium_impact	0.25	0.8	13.84	15.43	0.52	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4241	4241	C	T	MI.12708	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	935	312	S	F	tCc/tTc	-0.43	0	0	possibly_damaging	0.67	neutral	0.69	neutral	2.73	neutral	3.78	deleterious	-2.6	neutral_impact	0.5	0.85	neutral	0.75	neutral	1.34	12.47	neutral	0.22	0.45	0.12	neutral	0.32	neutral	0.34	neutral	0.44	neutral	1	0.6	neutral	0.51	deleterious	-3	neutral	0.42	neutral	-1.04	low_impact	0.47	medium_impact	-0.75	medium_impact	0.12	0.8	13.84	15.43	0.3	N	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4241	4241	C	A	MI.12709	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	935	312	S	Y	tCc/tAc	-0.43	0	0	possibly_damaging	0.67	neutral	1	neutral	2.72	neutral	-0.77	deleterious	-2.8	medium_impact	2.48	0.81	neutral	0.63	neutral	2.30	18.19	deleterious	0.19	0.45	0.19	neutral	0.35	neutral	0.33	neutral	0.45	neutral	1	0.67	neutral	0.67	deleterious	0	NA	0.49	deleterious	-1.04	low_impact	1.96	high_impact	0.98	medium_impact	0.20	0.8	13.84	15.43	0.24	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9124	9124	A	C	MI.1271	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	598	200	T	P	Act/Cct	-8.89	0	0	probably_damaging	1	neutral	0.2	neutral	4.23	deleterious	-4.44	deleterious	-5.11	high_impact	3.52	0.63	neutral	0.47	neutral	3.59	23.20	deleterious	0.13	0.65	NA	NA	0.92	disease	0.72	disease	0.8	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.05	medium_impact	1.92	medium_impact	0.54	0.9	22.12	17.17	0.37	N	0.99	polymorphism	0.76	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4243	4243	A	G	MI.12710	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	937	313	S	G	Agc/Ggc	-2.04	0	0	benign	0	neutral	0.36	neutral	2.78	neutral	-1.32	neutral	2.19	neutral_impact	-0.74	0.84	neutral	0.98	neutral	-0.74	0.06	neutral	0.35	0.5	0.1	neutral	0.02	neutral	0.29	neutral	0.18	neutral	6	0.64	neutral	0.68	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.14	medium_impact	-1.83	low_impact	0.56	0.8	21.38	23.07	0.4	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4243	4243	A	C	MI.12711	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	937	313	S	R	Agc/Cgc	-2.04	0	0	benign	0.18	neutral	0.34	neutral	2.77	neutral	-2.79	neutral	-2.28	medium_impact	2.5	0.7	neutral	0.41	neutral	2.31	18.21	deleterious	0.27	0.45	0.13	neutral	0.48	neutral	0.62	disease	0.58	disease	2	0.59	neutral	0.58	deleterious	-3	neutral	0.23	neutral	-0.13	medium_impact	0.11	medium_impact	1	medium_impact	0.35	0.8	21.38	23.07	0.36	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4243	4243	A	T	MI.12712	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	937	313	S	C	Agc/Tgc	-2.04	0	0	benign	0.01	neutral	0.18	neutral	2.7	deleterious	-4.58	neutral	-2.36	medium_impact	2.35	0.91	neutral	0.93	neutral	0.96	10.42	neutral	0.22	0.45	0.37	neutral	0.29	neutral	0.37	neutral	0.45	neutral	1	0.82	neutral	0.59	deleterious	-3	neutral	0.13	neutral	1.12	medium_impact	-0.09	medium_impact	0.86	medium_impact	0.31	0.8	21.38	23.07	0.52	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4244	4244	G	A	MI.12713	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	938	313	S	N	aGc/aAc	-0.66	0	0	benign	0	neutral	0.3	neutral	2.75	neutral	-2.47	neutral	-0.63	medium_impact	2.15	0.93	neutral	0.85	neutral	0.84	9.70	deleterious	0.55	0.6	0.16	neutral	0.25	neutral	0.38	neutral	0.43	neutral	1	0.7	neutral	0.65	deleterious	-3	neutral	0.11	neutral	2.07	high_impact	0.07	medium_impact	0.69	medium_impact	0.43	0.8	21.38	23.07	0.42	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4244	4244	G	T	MI.12714	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	938	313	S	I	aGc/aTc	-0.66	0	0	benign	0.14	neutral	0.44	neutral	2.76	neutral	-2.2	deleterious	-3.5	low_impact	1.38	0.75	neutral	0.62	neutral	2.57	19.94	deleterious	0.18	0.45	0.16	neutral	0.39	neutral	0.39	neutral	0.45	neutral	1	0.48	neutral	0.65	deleterious	-6	neutral	0.20	neutral	-0.01	medium_impact	0.22	medium_impact	0.02	medium_impact	0.43	0.8	21.38	23.07	0.39	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4244	4244	G	C	MI.12715	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	938	313	S	T	aGc/aCc	-0.66	0	0	benign	0	neutral	0.43	neutral	2.78	neutral	-1.9	neutral	-1.71	medium_impact	2.24	0.78	neutral	0.69	neutral	1.81	15.05	deleterious	0.41	0.5	0.12	neutral	0.15	neutral	0.46	neutral	0.3	neutral	4	0.56	neutral	0.72	deleterious	-3	neutral	0.10	neutral	2.07	high_impact	0.21	medium_impact	0.77	medium_impact	0.54	0.8	21.38	23.07	0.38	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4246	4246	A	T	MI.12716	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	940	314	I	F	Att/Ttt	-5.5	0	0	possibly_damaging	0.67	neutral	0.93	neutral	2.65	neutral	-1.96	neutral	-1.99	medium_impact	2.15	0.86	neutral	0.55	neutral	2.21	17.57	deleterious	0.18	0.45	0.23	neutral	0.19	neutral	0.54	disease	0.39	neutral	2	0.64	neutral	0.63	deleterious	0	NA	0.39	neutral	-1.04	low_impact	0.9	medium_impact	0.69	medium_impact	0.44	0.8	42.14	8.64	0.23	N	0.96	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4246	4246	A	C	MI.12717	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	940	314	I	L	Att/Ctt	-5.5	0	0	benign	0.09	neutral	0.94	neutral	2.85	neutral	2.53	neutral	0.66	neutral_impact	-0.62	0.8	neutral	0.66	neutral	-0.54	0.17	neutral	0.24	0.45	0.05	neutral	0.02	neutral	0.25	neutral	0.2	neutral	6	0.03	neutral	0.93	deleterious	-6	neutral	0.07	neutral	0.19	medium_impact	0.94	medium_impact	-1.73	low_impact	0.42	0.8	42.14	8.64	0.32	N	0.61	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4246	4246	A	G	MI.12718	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	940	314	I	V	Att/Gtt	-5.5	0	0	benign	0.01	neutral	0.68	neutral	2.82	neutral	-0.73	neutral	-0.73	low_impact	1.58	0.89	neutral	0.89	neutral	0.32	5.90	deleterious	0.3	0.45	0.08	neutral	0.05	neutral	0.4	neutral	0.27	neutral	5	0.3	neutral	0.84	deleterious	-6	neutral	0.04	neutral	1.12	medium_impact	0.46	medium_impact	0.19	medium_impact	0.34	0.8	42.14	8.64	0.43	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4247	4247	T	G	MI.12719	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	941	314	I	S	aTt/aGt	0.26	0	0	benign	0.32	neutral	0.64	neutral	2.67	neutral	-1.77	deleterious	-3.52	low_impact	1.63	0.74	neutral	0.55	neutral	2.62	20.30	deleterious	0.13	0.4	0.37	neutral	0.25	neutral	0.43	neutral	0.46	neutral	1	0.28	neutral	0.66	deleterious	-6	neutral	0.24	neutral	-0.44	medium_impact	0.42	medium_impact	0.24	medium_impact	0.27	0.8	42.14	8.64	0.3	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9124	9124	A	T	MI.1272	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	598	200	T	S	Act/Tct	-8.89	0	0	probably_damaging	0.99	neutral	0.41	neutral	4.27	neutral	-1.63	deleterious	-3.36	low_impact	1.56	0.74	neutral	0.7	neutral	2.35	18.47	deleterious	0.44	0.65	NA	NA	0.71	disease	0.38	neutral	0.5	disease	0	0.99	deleterious	0.21	neutral	-2	neutral	0.82	deleterious	-2.65	low_impact	0.2	medium_impact	0.24	medium_impact	0.63	0.9	22.12	17.17	0.32	N	0.88	polymorphism	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4247	4247	T	A	MI.12720	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	941	314	I	N	aTt/aAt	0.26	0	0	possibly_damaging	0.52	neutral	0.43	neutral	2.63	deleterious	-3.48	deleterious	-4.36	medium_impact	2.58	0.73	neutral	0.51	neutral	2.73	21.00	deleterious	0.17	0.45	0.52	disease	0.26	neutral	0.63	disease	0.51	disease	0	0.56	neutral	0.46	neutral	0	NA	0.44	deleterious	-0.78	medium_impact	0.21	medium_impact	1.07	medium_impact	0.20	0.8	42.14	8.64	0.35	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4247	4247	T	C	MI.12721	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	941	314	I	T	aTt/aCt	0.26	0	0	benign	0.01	neutral	0.43	neutral	2.68	neutral	-0.7	deleterious	-2.61	neutral_impact	0.78	0.88	neutral	0.71	neutral	1.59	13.80	neutral	0.16	0.45	0.27	neutral	0.09	neutral	0.42	neutral	0.3	neutral	4	0.56	neutral	0.71	deleterious	-6	neutral	0.08	neutral	1.12	medium_impact	0.21	medium_impact	-0.51	medium_impact	0.32	0.8	42.14	8.64	0.45	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4248	4248	T	A	MI.12722	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	942	314	I	M	atT/atA	3.71	0.37	0.18	possibly_damaging	0.67	neutral	0.38	neutral	2.65	neutral	-2.18	neutral	-0.66	medium_impact	2.58	0.86	neutral	0.52	neutral	2.21	17.55	deleterious	0.32	0.5	0.2	neutral	0.08	neutral	0.61	disease	0.35	neutral	3	0.7	neutral	0.36	neutral	0	NA	0.40	neutral	-1.04	low_impact	0.16	medium_impact	1.07	medium_impact	0.45	0.8	42.14	8.64	0.47	N	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4248	4248	T	G	MI.12723	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	942	314	I	M	atT/atG	3.71	0.37	0.18	possibly_damaging	0.67	neutral	0.38	neutral	2.65	neutral	-2.18	neutral	-0.66	medium_impact	2.58	0.86	neutral	0.52	neutral	1.90	15.58	deleterious	0.32	0.5	0.2	neutral	0.08	neutral	0.61	disease	0.35	neutral	3	0.7	neutral	0.36	neutral	0	NA	0.40	neutral	-1.04	low_impact	0.16	medium_impact	1.07	medium_impact	0.45	0.8	42.14	8.64	0.47	N	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4249	4249	C	G	MI.12724	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	943	315	P	A	Ccc/Gcc	-9.87	0	0	probably_damaging	1	neutral	0.51	neutral	2.64	deleterious	-10.58	deleterious	-6.57	high_impact	4.41	0.82	neutral	0.23	damaging	3.29	22.80	deleterious	0.25	0.45	0.28	neutral	0.14	neutral	0.62	disease	0.27	neutral	5	1	deleterious	0.26	neutral	2	deleterious	0.67	deleterious	-3.57	low_impact	0.29	medium_impact	2.66	high_impact	0.44	0.8	58.49	10.47	0.37	N	0.75	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4249	4249	C	T	MI.12725	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	943	315	P	S	Ccc/Tcc	-9.87	0	0	probably_damaging	1	neutral	0.4	neutral	2.62	deleterious	-10.9	deleterious	-6.6	high_impact	4.07	0.78	neutral	0.18	damaging	4.13	23.80	deleterious	0.3	0.45	0.31	neutral	0.32	neutral	0.6	disease	0.43	neutral	1	1	deleterious	0.2	neutral	2	deleterious	0.71	deleterious	-3.57	low_impact	0.18	medium_impact	2.37	high_impact	0.26	0.8	58.49	10.47	0.34	N	0.70	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4249	4249	C	A	MI.12726	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	943	315	P	T	Ccc/Acc	-9.87	0	0	probably_damaging	1	neutral	0.39	neutral	2.59	deleterious	-11.33	deleterious	-6.6	high_impact	4.41	0.72	neutral	0.15	damaging	3.93	23.50	deleterious	0.31	0.45	0.37	neutral	0.32	neutral	0.68	disease	0.46	neutral	1	1	deleterious	0.2	neutral	2	deleterious	0.71	deleterious	-3.57	low_impact	0.17	medium_impact	2.66	high_impact	0.31	0.8	58.49	10.47	0.37	N	0.90	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4250	4250	C	T	MI.12727	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	944	315	P	L	cCc/cTc	3.48	0.99	0	probably_damaging	1	neutral	0.65	neutral	2.57	deleterious	-11.84	deleterious	-8.27	high_impact	3.72	0.77	neutral	0.13	damaging	4.63	24.50	deleterious	0.22	0.45	0.42	neutral	0.31	neutral	0.65	disease	0.44	neutral	1	1	deleterious	0.33	neutral	2	deleterious	0.72	deleterious	-3.57	low_impact	0.43	medium_impact	2.06	high_impact	0.54	0.8	58.49	10.47	0.48	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4250	4250	C	A	MI.12728	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	944	315	P	H	cCc/cAc	3.48	0.99	0	probably_damaging	1	neutral	0.54	neutral	2.53	deleterious	-12.86	deleterious	-7.45	high_impact	4.41	0.76	neutral	0.14	damaging	4.24	23.90	deleterious	0.22	0.45	0.61	disease	0.36	neutral	0.72	disease	0.6	disease	2	1	deleterious	0.27	neutral	2	deleterious	0.75	deleterious	-3.57	low_impact	0.31	medium_impact	2.66	high_impact	0.26	0.8	58.49	10.47	0.51	N	0.69	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4250	4250	C	G	MI.12729	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	944	315	P	R	cCc/cGc	3.48	0.99	0	probably_damaging	1	neutral	0.34	neutral	2.56	deleterious	-11.89	deleterious	-7.45	high_impact	4.41	0.78	neutral	0.15	damaging	3.86	23.50	deleterious	0.2	0.45	0.44	neutral	0.41	neutral	0.74	disease	0.5	neutral	0	1	deleterious	0.17	neutral	2	deleterious	0.74	deleterious	-3.57	low_impact	0.11	medium_impact	2.66	high_impact	0.31	0.8	58.49	10.47	0.49	N	0.73	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9124	9124	A	G	MI.1273	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	598	200	T	A	Act/Gct	-8.89	0	0	probably_damaging	0.99	neutral	0.52	neutral	4.37	neutral	-1.75	deleterious	-4.09	medium_impact	3.17	0.79	neutral	0.61	neutral	3.61	23.20	deleterious	0.58	0.7	NA	NA	0.68	disease	0.56	disease	0.58	disease	2	0.99	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	0.31	medium_impact	1.62	medium_impact	0.41	0.9	22.12	17.17	0.27	N	0.63	polymorphism	0.94	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4252	4252	C	T	MI.12730	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	946	316	P	S	Cct/Tct	-8.95	0	0	probably_damaging	1	neutral	0.41	neutral	2.67	neutral	-0.35	deleterious	-6.66	medium_impact	3.4	0.53	damaging	0.1	damaging	4.12	23.80	deleterious	0.46	0.55	0.09	neutral	0.3	neutral	0.56	disease	0.43	neutral	1	1	deleterious	0.21	neutral	1	deleterious	0.67	deleterious	-3.57	low_impact	0.19	medium_impact	1.78	medium_impact	0.27	0.8	NA	NA	0.34	N	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4252	4252	C	A	MI.12731	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	946	316	P	T	Cct/Act	-8.95	0	0	probably_damaging	1	neutral	0.4	neutral	2.63	neutral	-0.74	deleterious	-6.66	high_impact	4.04	0.55	damaging	0.08	damaging	3.93	23.50	deleterious	0.37	0.5	0.14	neutral	0.31	neutral	0.52	disease	0.43	neutral	2	1	deleterious	0.2	neutral	2	deleterious	0.67	deleterious	-3.57	low_impact	0.18	medium_impact	2.34	high_impact	0.30	0.8	NA	NA	0.34	N	0.90	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4252	4252	C	G	MI.12732	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	946	316	P	A	Cct/Gct	-8.95	0	0	probably_damaging	1	neutral	0.53	neutral	2.68	neutral	-0.07	deleterious	-6.67	high_impact	4.38	0.57	damaging	0.12	damaging	3.28	22.80	deleterious	0.4	0.5	0.1	neutral	0.15	neutral	0.56	disease	0.32	neutral	4	1	deleterious	0.27	neutral	2	deleterious	0.64	deleterious	-3.57	low_impact	0.3	medium_impact	2.64	high_impact	0.40	0.8	NA	NA	0.36	N	0.75	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4253	4253	C	T	MI.12733	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	947	316	P	L	cCt/cTt	5.55	0.94	0	probably_damaging	1	neutral	0.67	neutral	2.62	neutral	-0.66	deleterious	-8.32	high_impact	4.38	0.6	damaging	0.06	damaging	4.50	24.30	deleterious	0.34	0.5	0.21	neutral	0.3	neutral	0.55	disease	0.43	neutral	1	1	deleterious	0.34	neutral	2	deleterious	0.68	deleterious	-3.57	low_impact	0.45	medium_impact	2.64	high_impact	0.68	0.85	NA	NA	0.52	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4253	4253	C	A	MI.12734	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	947	316	P	H	cCt/cAt	5.55	0.94	0	probably_damaging	1	neutral	0.54	neutral	2.57	neutral	-2.27	deleterious	-7.5	high_impact	4.38	0.57	damaging	0.06	damaging	4.10	23.70	deleterious	0.3	0.45	0.34	neutral	0.34	neutral	0.62	disease	0.43	neutral	1	1	deleterious	0.27	neutral	2	deleterious	0.71	deleterious	-3.57	low_impact	0.31	medium_impact	2.64	high_impact	0.24	0.8	NA	NA	0.51	P	0.69	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4253	4253	C	G	MI.12735	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	947	316	P	R	cCt/cGt	5.55	0.94	0	probably_damaging	1	neutral	0.35	neutral	2.61	neutral	-1.08	deleterious	-7.51	high_impact	4.04	0.56	damaging	0.07	damaging	3.79	23.40	deleterious	0.27	0.45	0.2	neutral	0.4	neutral	0.64	disease	0.42	neutral	2	1	deleterious	0.18	neutral	2	deleterious	0.70	deleterious	-3.57	low_impact	0.12	medium_impact	2.34	high_impact	0.22	0.8	NA	NA	0.54	P	0.73	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4255	4255	C	G	MI.12736	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	949	317	Q	E	Caa/Gaa	-14.01	0	0	benign	0.31	neutral	0.3	neutral	2.8	neutral	0.18	neutral	-1.76	medium_impact	3.26	0.75	neutral	0.14	damaging	3.07	22.40	deleterious	0.56	0.6	0.09	neutral	0.15	neutral	0.48	neutral	0.27	neutral	5	0.64	neutral	0.5	deleterious	-3	neutral	0.36	neutral	-0.43	medium_impact	0.07	medium_impact	1.66	medium_impact	0.38	0.8	21.07	21.46	0.39	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4255	4255	C	A	MI.12737	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	949	317	Q	K	Caa/Aaa	-14.01	0	0	possibly_damaging	0.51	neutral	0.31	neutral	2.84	neutral	0.37	neutral	-2.12	high_impact	3.6	0.82	neutral	0.2	damaging	4.00	23.60	deleterious	0.47	0.55	0.07	neutral	0.19	neutral	0.48	neutral	0.31	neutral	4	0.67	neutral	0.4	neutral	1	deleterious	0.46	deleterious	-0.77	medium_impact	0.08	medium_impact	1.96	medium_impact	0.44	0.8	21.07	21.46	0.38	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4256	4256	A	C	MI.12738	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	950	317	Q	P	cAa/cCa	3.48	0.96	0	possibly_damaging	0.89	neutral	0.23	neutral	2.72	neutral	-1.47	deleterious	-3.38	medium_impact	3.06	0.66	neutral	0.12	damaging	3.47	23.00	deleterious	0.15	0.45	0.23	neutral	0.29	neutral	0.44	neutral	0.4	neutral	2	0.92	neutral	0.17	neutral	0	NA	0.66	deleterious	-1.6	low_impact	-0.02	medium_impact	1.48	medium_impact	0.32	0.8	21.07	21.46	0.51	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4256	4256	A	G	MI.12739	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	950	317	Q	R	cAa/cGa	3.48	0.96	0	possibly_damaging	0.51	neutral	0.36	neutral	2.8	neutral	-0.04	neutral	-2.1	high_impact	3.6	0.84	neutral	0.18	damaging	3.55	23.10	deleterious	0.44	0.55	0.09	neutral	0.2	neutral	0.4	neutral	0.35	neutral	3	0.62	neutral	0.43	neutral	1	deleterious	0.47	deleterious	-0.77	medium_impact	0.14	medium_impact	1.96	medium_impact	0.39	0.8	21.07	21.46	0.49	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9125	9125	C	A	MI.1274	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	599	200	T	N	aCt/aAt	5.68	0.98	0	probably_damaging	1	neutral	0.33	neutral	4.24	neutral	-2.49	deleterious	-4.28	medium_impact	3.06	0.7	neutral	0.54	neutral	3.66	23.20	deleterious	0.52	0.65	NA	NA	0.84	disease	0.6	disease	0.72	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.12	medium_impact	1.53	medium_impact	0.77	0.9	22.12	17.17	0.52	N	0.90	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4256	4256	A	T	MI.12740	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	950	317	Q	L	cAa/cTa	3.48	0.96	0	possibly_damaging	0.71	neutral	0.68	neutral	2.79	neutral	0.44	deleterious	-2.94	low_impact	1.04	0.88	neutral	0.86	neutral	2.87	21.70	deleterious	0.23	0.45	0.12	neutral	0.17	neutral	0.42	neutral	0.28	neutral	4	0.65	neutral	0.49	deleterious	-3	neutral	0.49	deleterious	-1.12	low_impact	0.46	medium_impact	-0.28	medium_impact	0.27	0.8	21.07	21.46	0.42	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4257	4257	A	T	MI.12741	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	951	317	Q	H	caA/caT	3.25	0.97	0	benign	0.05	neutral	0.54	neutral	2.73	neutral	-1.35	neutral	-2.14	medium_impact	2.56	0.88	neutral	0.79	neutral	2.51	19.50	deleterious	0.34	0.5	0.19	neutral	0.08	neutral	0.37	neutral	0.28	neutral	4	0.41	neutral	0.75	deleterious	-3	neutral	0.14	neutral	0.45	medium_impact	0.31	medium_impact	1.05	medium_impact	0.30	0.8	21.07	21.46	0.51	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4257	4257	A	C	MI.12742	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	951	317	Q	H	caA/caC	3.25	0.97	0	benign	0.05	neutral	0.54	neutral	2.73	neutral	-1.35	neutral	-2.14	medium_impact	2.56	0.88	neutral	0.79	neutral	2.36	18.54	deleterious	0.34	0.5	0.19	neutral	0.08	neutral	0.37	neutral	0.28	neutral	4	0.41	neutral	0.75	deleterious	-3	neutral	0.14	neutral	0.45	medium_impact	0.31	medium_impact	1.05	medium_impact	0.30	0.8	21.07	21.46	0.5	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4258	4258	A	G	MI.12743	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	952	318	T	A	Acc/Gcc	0.49	0	0	benign	0.11	neutral	0.66	neutral	2.81	neutral	0.26	neutral	-0.9	medium_impact	2.15	0.81	neutral	0.66	neutral	3.45	23.00	deleterious	0.2	0.45	0.07	neutral	0.05	neutral	0.44	neutral	0.15	neutral	7	0.23	neutral	0.78	deleterious	-3	neutral	0.19	neutral	0.1	medium_impact	0.44	medium_impact	0.69	medium_impact	0.40	0.8	NA	NA	0.39	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4258	4258	A	C	MI.12744	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	952	318	T	P	Acc/Ccc	0.49	0	0	possibly_damaging	0.65	neutral	0.32	neutral	2.7	neutral	-1.56	neutral	-1.47	low_impact	1.92	0.64	neutral	0.44	neutral	3.51	23.10	deleterious	0.14	0.4	0.22	neutral	0.18	neutral	0.54	disease	0.31	neutral	4	0.73	neutral	0.34	neutral	-3	neutral	0.68	deleterious	-1	low_impact	0.09	medium_impact	0.49	medium_impact	0.42	0.8	NA	NA	0.45	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4258	4258	A	T	MI.12745	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	952	318	T	S	Acc/Tcc	0.49	0	0	benign	0.02	neutral	0.5	neutral	2.78	neutral	-0.07	neutral	-0.88	low_impact	1.23	0.88	neutral	0.87	neutral	2.16	17.25	deleterious	0.27	0.45	0.07	neutral	0.05	neutral	0.37	neutral	0.13	neutral	7	0.48	neutral	0.74	deleterious	-6	neutral	0.06	neutral	0.84	medium_impact	0.28	medium_impact	-0.11	medium_impact	0.51	0.8	NA	NA	0.43	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4259	4259	C	T	MI.12746	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	953	318	T	I	aCc/aTc	-0.89	0	0	possibly_damaging	0.65	neutral	0.44	neutral	2.76	neutral	-0.23	neutral	-0.13	low_impact	1.36	0.77	neutral	0.64	neutral	4.01	23.60	deleterious	0.16	0.45	0.18	neutral	0.16	neutral	0.53	disease	0.28	neutral	4	0.65	neutral	0.4	neutral	-3	neutral	0.68	deleterious	-1	low_impact	0.22	medium_impact	0	medium_impact	0.41	0.8	NA	NA	0.35	N	0.75	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4259	4259	C	A	MI.12747	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	953	318	T	N	aCc/aAc	-0.89	0	0	benign	0.02	neutral	0.33	neutral	2.72	neutral	-0.96	neutral	-1.51	low_impact	1.02	0.89	neutral	0.71	neutral	3.91	23.50	deleterious	0.31	0.5	0.16	neutral	0.12	neutral	0.43	neutral	0.19	neutral	6	0.66	neutral	0.66	deleterious	-6	neutral	0.06	neutral	0.84	medium_impact	0.1	medium_impact	-0.3	medium_impact	0.42	0.8	NA	NA	0.5	N	0.81	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4259	4259	C	G	MI.12748	MT-ND1	I	ENSG00000198888	ENSP00000354687	ENST00000361390	NU1M_HUMAN	P03886	4535	YP_003024026.1	953	318	T	S	aCc/aGc	-0.89	0	0	benign	0.02	neutral	0.5	neutral	2.78	neutral	-0.07	neutral	-0.88	low_impact	1.23	0.88	neutral	0.87	neutral	2.48	19.31	deleterious	0.27	0.45	0.07	neutral	0.05	neutral	0.37	neutral	0.13	neutral	7	0.48	neutral	0.74	deleterious	-6	neutral	0.06	neutral	0.84	medium_impact	0.28	medium_impact	-0.11	medium_impact	0.51	0.8	NA	NA	0.41	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4470	4470	A	C	MI.12749	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1	1	M	L	Atg/Ctg	6.94	1	0	possibly_damaging	0.75	deleterious	0	NA	NA	neutral	1.04	NA	NA	NA	NA	0.78	neutral	0.46	neutral	1.55	13.61	neutral	0.11	0.4	NA	NA	0.28	neutral	0.56	disease	0.38	neutral	2	1	deleterious	0.13	neutral	3	deleterious	NA	deleterious	NA	NA	NA	NA	NA	NA	0.20	0.8	NA	NA	0.6	P	0.62	NA	NA	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9125	9125	C	G	MI.1275	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	599	200	T	S	aCt/aGt	5.68	0.98	0	probably_damaging	0.99	neutral	0.41	neutral	4.27	neutral	-1.63	deleterious	-3.36	low_impact	1.56	0.74	neutral	0.7	neutral	2.54	19.75	deleterious	0.44	0.65	NA	NA	0.71	disease	0.38	neutral	0.5	disease	0	0.99	deleterious	0.21	neutral	-2	neutral	0.82	deleterious	-2.65	low_impact	0.2	medium_impact	0.24	medium_impact	0.63	0.9	22.12	17.17	0.49	N	0.88	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4470	4470	A	T	MI.12750	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1	1	M	L	Atg/Ttg	6.94	1	0	possibly_damaging	0.75	deleterious	0	NA	NA	neutral	1.04	NA	NA	NA	NA	0.78	neutral	0.46	neutral	1.51	13.39	neutral	0.11	0.4	NA	NA	0.28	neutral	0.56	disease	0.38	neutral	2	1	deleterious	0.13	neutral	3	deleterious	NA	deleterious	NA	NA	NA	NA	NA	NA	0.20	0.8	NA	NA	0.6	P	0.62	NA	NA	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4470	4470	A	G	MI.12751	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1	1	M	V	Atg/Gtg	6.94	1	0	possibly_damaging	0.83	deleterious	0	NA	NA	neutral	0.48	NA	NA	NA	NA	0.74	neutral	0.49	neutral	0.83	9.65	deleterious	0.16	0.45	NA	NA	0.35	neutral	0.59	disease	0.37	neutral	3	1	deleterious	0.09	neutral	3	deleterious	0.21	neutral	NA	NA	NA	NA	NA	NA	0.18	0.8	NA	NA	0.58	P	0.73	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4471	4471	T	A	MI.12752	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	2	1	M	K	aTg/aAg	3.48	1	0	probably_damaging	0.92	deleterious	0	NA	NA	neutral	-0.67	NA	NA	NA	NA	0.8	neutral	0.41	neutral	2.33	18.35	deleterious	0.08	0.35	NA	NA	0.49	neutral	0.62	disease	0.55	disease	1	1	deleterious	0.04	neutral	4	deleterious	NA	deleterious	NA	NA	NA	NA	NA	NA	0.07	0.8	NA	NA	0.44	N	0.93	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4471	4471	T	C	MI.12753	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	2	1	M	T	aTg/aCg	3.48	1	0	probably_damaging	0.92	deleterious	0	NA	NA	neutral	-0.72	NA	NA	NA	NA	0.77	neutral	0.48	neutral	1.22	11.88	neutral	0.09	0.35	NA	NA	0.48	neutral	0.59	disease	0.48	neutral	0	1	deleterious	0.04	neutral	4	deleterious	0.30	neutral	NA	NA	NA	NA	NA	NA	0.06	0.8	NA	NA	0.42	N	0.78	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4472	4472	T	G	MI.12754	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	3	1	M	I	atT/atG	3.71	1	0	possibly_damaging	0.88	deleterious	0	NA	NA	neutral	0.37	NA	NA	NA	NA	0.86	neutral	0.77	neutral	NA	NA	NA	0.11	0.4	NA	NA	0.32	neutral	0.42	neutral	0.18	neutral	6	1	deleterious	0.06	neutral	3	deleterious	NA	deleterious	NA	NA	NA	NA	NA	NA	0.29	0.8	NA	NA	0.49	P	0.05	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NA
chrM	4472	4472	T	C	MI.12755	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	3	1	M	I	atT/atC	-1.81	0	0	possibly_damaging	0.88	deleterious	0	NA	NA	neutral	0.37	NA	NA	NA	NA	0.86	neutral	0.77	neutral	NA	NA	NA	0.11	0.4	NA	NA	0.32	neutral	0.42	neutral	0.18	neutral	6	1	deleterious	0.06	neutral	3	deleterious	NA	deleterious	NA	NA	NA	NA	NA	NA	0.29	0.8	NA	NA	0.39	N	0.05	NA	NA	0.10	rs1057520067	Uncertain_significance	not_provided	363712	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4473	4473	A	C	MI.12756	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	4	2	N	H	Aat/Cat	-1.81	0	0	probably_damaging	1	neutral	0.53	neutral	4.06	neutral	-1.98	deleterious	-4.12	medium_impact	2.93	0.86	neutral	0.12	damaging	2.81	21.40	deleterious	0.6	0.65	NA	NA	0.33	neutral	0.39	neutral	0.19	neutral	6	1	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.24	medium_impact	1.32	medium_impact	0.14	0.8	0.86	6.99	0.25	N	0.54	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NA
chrM	4473	4473	A	G	MI.12757	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	4	2	N	D	Aat/Gat	-1.81	0	0	probably_damaging	1	neutral	0.2	neutral	4.15	neutral	-0.36	deleterious	-4.12	medium_impact	3.07	0.84	neutral	0.13	damaging	3.56	23.10	deleterious	0.8	0.85	NA	NA	0.3	neutral	0.53	disease	0.35	neutral	3	1	deleterious	0.1	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	-0.13	medium_impact	1.44	medium_impact	0.39	0.8	0.86	6.99	0.41	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4473	4473	A	T	MI.12758	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	4	2	N	Y	Aat/Tat	-1.81	0	0	probably_damaging	1	neutral	1	neutral	4.05	neutral	-1.98	deleterious	-6.49	medium_impact	2.82	0.88	neutral	0.13	damaging	3.43	23.00	deleterious	0.24	0.45	NA	NA	0.45	neutral	0.53	disease	0.39	neutral	2	1	deleterious	0.5	deleterious	1	deleterious	0.73	deleterious	-3.54	low_impact	1.87	high_impact	1.23	medium_impact	0.16	0.8	0.86	6.99	0.25	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4474	4474	A	C	MI.12759	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	5	2	N	T	aAt/aCt	2.79	0.02	0	probably_damaging	1	neutral	0.43	neutral	4.12	neutral	-0.46	deleterious	-4.88	medium_impact	2.34	0.87	neutral	0.32	neutral	3.12	22.60	deleterious	0.55	0.6	NA	NA	0.34	neutral	0.33	neutral	0.19	neutral	6	1	deleterious	0.22	neutral	1	deleterious	0.71	deleterious	-3.54	low_impact	0.14	medium_impact	0.83	medium_impact	0.25	0.8	0.86	6.99	0.38	N	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9125	9125	C	T	MI.1276	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	599	200	T	I	aCt/aTt	5.68	0.98	0	probably_damaging	1	neutral	0.47	neutral	4.38	neutral	-1.8	deleterious	-4.65	low_impact	1.94	0.87	neutral	0.78	neutral	3.98	23.60	deleterious	0.47	0.65	NA	NA	0.9	disease	0.41	neutral	0.53	disease	1	0.99	deleterious	0.24	neutral	-2	neutral	0.85	deleterious	-3.6	low_impact	0.26	medium_impact	0.57	medium_impact	0.58	0.9	22.12	17.17	0.48	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4474	4474	A	G	MI.12760	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	5	2	N	S	aAt/aGt	2.79	0.02	0	probably_damaging	1	neutral	0.46	neutral	4.17	neutral	0.09	deleterious	-4.01	low_impact	1.64	0.89	neutral	0.86	neutral	1.51	13.39	neutral	0.77	0.8	NA	NA	0.1	neutral	0.18	neutral	0.26	neutral	5	1	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-3.54	low_impact	0.17	medium_impact	0.24	medium_impact	0.32	0.8	0.86	6.99	0.44	N	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4474	4474	A	T	MI.12761	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	5	2	N	I	aAt/aTt	2.79	0.02	0	probably_damaging	1	neutral	0.4	neutral	4.07	neutral	-1.34	deleterious	-7.33	medium_impact	2.42	0.88	neutral	0.22	damaging	3.65	23.20	deleterious	0.22	0.45	NA	NA	0.52	disease	0.5	neutral	0.5	neutral	0	1	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.11	medium_impact	0.89	medium_impact	0.16	0.8	0.86	6.99	0.38	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4475	4475	T	G	MI.12762	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	6	2	N	K	aaT/aaG	0.72	0	0	probably_damaging	1	neutral	0.33	neutral	4.14	neutral	-0.27	deleterious	-4.3	low_impact	1.1	0.92	neutral	0.85	neutral	2.51	19.53	deleterious	0.65	0.7	NA	NA	0.3	neutral	0.39	neutral	0.17	neutral	7	1	deleterious	0.17	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.04	medium_impact	-0.22	medium_impact	0.50	0.8	0.86	6.99	0.49	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4475	4475	T	A	MI.12763	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	6	2	N	K	aaT/aaA	0.72	0	0	probably_damaging	1	neutral	0.33	neutral	4.14	neutral	-0.27	deleterious	-4.3	low_impact	1.1	0.92	neutral	0.85	neutral	2.82	21.50	deleterious	0.65	0.7	NA	NA	0.3	neutral	0.39	neutral	0.17	neutral	7	1	deleterious	0.17	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.04	medium_impact	-0.22	medium_impact	0.50	0.8	0.86	6.99	0.49	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4476	4476	C	T	MI.12764	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	7	3	P	S	Ccc/Tcc	-4.35	0	0	probably_damaging	1	neutral	0.7	neutral	4.1	neutral	-0.48	deleterious	-6.87	medium_impact	2.52	0.86	neutral	0.57	neutral	3.63	23.20	deleterious	0.46	0.55	NA	NA	0.49	neutral	0.5	neutral	0.37	neutral	3	1	deleterious	0.35	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.41	medium_impact	0.98	medium_impact	0.28	0.8	0.86	9.39	0.25	N	0.62	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4476	4476	C	A	MI.12765	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	7	3	P	T	Ccc/Acc	-4.35	0	0	probably_damaging	1	neutral	0.59	neutral	4.07	neutral	-0.88	deleterious	-6.86	medium_impact	2.56	0.92	neutral	0.45	neutral	3.64	23.20	deleterious	0.38	0.5	NA	NA	0.51	disease	0.39	neutral	0.5	neutral	0	1	deleterious	0.3	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.3	medium_impact	1.01	medium_impact	0.58	0.8	0.86	9.39	0.29	N	0.79	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4476	4476	C	G	MI.12766	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	7	3	P	A	Ccc/Gcc	-4.35	0	0	probably_damaging	1	neutral	0.77	neutral	4.12	neutral	-0.25	deleterious	-6.87	medium_impact	3.25	0.88	neutral	0.57	neutral	2.88	21.80	deleterious	0.44	0.55	NA	NA	0.28	neutral	0.51	disease	0.25	neutral	5	1	deleterious	0.39	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.5	medium_impact	1.59	medium_impact	0.65	0.8	0.86	9.39	0.33	N	0.60	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4477	4477	C	A	MI.12767	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	8	3	P	H	cCc/cAc	3.48	0.93	0	probably_damaging	1	neutral	0.57	neutral	4.01	neutral	-2.44	deleterious	-7.63	medium_impact	3.25	0.88	neutral	0.4	neutral	3.79	23.40	deleterious	0.25	0.45	NA	NA	0.52	disease	0.59	disease	0.64	disease	3	1	deleterious	0.29	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.28	medium_impact	1.59	medium_impact	0.30	0.8	0.86	9.39	0.41	N	0.86	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4477	4477	C	T	MI.12768	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	8	3	P	L	cCc/cTc	3.48	0.93	0	probably_damaging	1	neutral	0.8	neutral	4.05	neutral	-0.89	deleterious	-8.39	medium_impact	2.5	0.93	neutral	0.47	neutral	4.18	23.80	deleterious	0.32	0.5	NA	NA	0.5	neutral	0.51	disease	0.51	disease	0	1	deleterious	0.4	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.54	medium_impact	0.96	medium_impact	0.71	0.85	0.86	9.39	0.39	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4477	4477	C	G	MI.12769	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	8	3	P	R	cCc/cGc	3.48	0.93	0	probably_damaging	1	neutral	0.54	neutral	4.05	neutral	-1.2	deleterious	-7.63	medium_impact	3.13	0.86	neutral	0.41	neutral	3.44	23.00	deleterious	0.21	0.45	NA	NA	0.58	disease	0.62	disease	0.64	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.25	medium_impact	1.49	medium_impact	0.37	0.8	0.86	9.39	0.34	N	0.90	polymorphism	1	0.09	rs28430764	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9127	9127	A	T	MI.1277	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	601	201	I	F	Atc/Ttc	-9.36	0	0	benign	0.12	neutral	0.13	neutral	4.19	neutral	-0.17	deleterious	-2.79	low_impact	1.72	0.83	neutral	0.44	neutral	1.12	11.30	neutral	0.45	0.65	NA	NA	0.74	disease	0.41	neutral	0.52	disease	0	0.85	neutral	0.51	deleterious	-6	neutral	0.29	neutral	0.07	medium_impact	-0.18	medium_impact	0.38	medium_impact	0.67	0.9	14.6	19.22	0.35	N	0.84	polymorphism	0.86	0.07	rs199732761	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4479	4479	C	G	MI.12770	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	10	4	L	V	Ctg/Gtg	-5.04	0	0	probably_damaging	0.95	neutral	0.43	neutral	4.22	neutral	-0.23	neutral	-1.32	medium_impact	2.46	0.92	neutral	0.87	neutral	2.15	17.17	deleterious	0.42	0.55	NA	NA	0.14	neutral	0.34	neutral	0.24	neutral	5	0.95	neutral	0.24	neutral	1	deleterious	0.63	deleterious	-1.97	low_impact	0.14	medium_impact	0.93	medium_impact	0.43	0.8	3.17	7.69	0.41	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4479	4479	C	A	MI.12771	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	10	4	L	M	Ctg/Atg	-5.04	0	0	probably_damaging	0.99	neutral	0.26	neutral	4.15	neutral	-1.46	neutral	-0.94	low_impact	1.26	0.94	neutral	0.87	neutral	2.24	17.76	deleterious	0.35	0.5	NA	NA	0.07	neutral	0.17	neutral	0.24	neutral	5	0.99	deleterious	0.14	neutral	-2	neutral	0.65	deleterious	-2.62	low_impact	-0.04	medium_impact	-0.08	medium_impact	0.50	0.8	3.17	7.69	0.58	P	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4480	4480	T	A	MI.12772	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	11	4	L	Q	cTg/cAg	-4.11	0	0	probably_damaging	0.99	neutral	0.25	neutral	4.17	neutral	-1.13	deleterious	-4.16	low_impact	1.71	0.85	neutral	0.7	neutral	2.90	21.80	deleterious	0.14	0.4	NA	NA	0.09	neutral	0.26	neutral	0.21	neutral	6	0.99	deleterious	0.13	neutral	-2	neutral	0.67	deleterious	-2.62	low_impact	-0.06	medium_impact	0.3	medium_impact	0.19	0.8	3.17	7.69	0.44	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4480	4480	T	C	MI.12773	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	11	4	L	P	cTg/cCg	-4.11	0	0	benign	0.32	neutral	0.2	neutral	4.12	neutral	-2.36	deleterious	-4.41	low_impact	1.23	0.92	neutral	0.84	neutral	2.31	18.26	deleterious	0.09	0.35	NA	NA	0.45	neutral	0.56	disease	0.36	neutral	3	0.76	neutral	0.44	neutral	-6	neutral	0.35	neutral	-0.5	medium_impact	-0.13	medium_impact	-0.11	medium_impact	0.25	0.8	3.17	7.69	0.46	N	0.47	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4480	4480	T	G	MI.12774	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	11	4	L	R	cTg/cGg	-4.11	0	0	probably_damaging	0.99	neutral	0.31	neutral	4.16	neutral	-1.11	deleterious	-4.3	medium_impact	2.61	0.86	neutral	0.51	neutral	3.96	23.60	deleterious	0.1	0.4	NA	NA	0.49	neutral	0.49	neutral	0.38	neutral	3	0.99	deleterious	0.16	neutral	1	deleterious	0.75	deleterious	-2.62	low_impact	0.02	medium_impact	1.05	medium_impact	0.17	0.8	3.17	7.69	0.37	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4482	4482	G	C	MI.12775	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	13	5	A	P	Gcc/Ccc	-6.19	0	0	possibly_damaging	0.83	neutral	0.25	neutral	4.1	neutral	-2.28	neutral	-2.41	low_impact	1.32	0.87	neutral	0.39	neutral	3.65	23.20	deleterious	0.13	0.4	NA	NA	0.69	disease	0.4	neutral	0.51	disease	0	0.88	neutral	0.21	neutral	-3	neutral	0.79	deleterious	-1.43	low_impact	-0.06	medium_impact	-0.03	medium_impact	0.43	0.8	10.37	8.87	0.37	N	0.77	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4482	4482	G	A	MI.12776	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	13	5	A	T	Gcc/Acc	-6.19	0	0	possibly_damaging	0.62	neutral	0.43	neutral	4.18	neutral	-0.58	neutral	-0.4	neutral_impact	-0.14	0.86	neutral	0.93	neutral	2.05	16.52	deleterious	0.24	0.45	NA	NA	0.2	neutral	0.16	neutral	0.22	neutral	6	0.63	neutral	0.41	neutral	-3	neutral	0.67	deleterious	-0.99	medium_impact	0.14	medium_impact	-1.26	low_impact	0.64	0.8	10.37	8.87	0.43	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4482	4482	G	T	MI.12777	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	13	5	A	S	Gcc/Tcc	-6.19	0	0	benign	0.33	neutral	0.62	neutral	4.18	neutral	-0.46	neutral	-1.36	neutral_impact	0.04	0.88	neutral	0.66	neutral	3.51	23.10	deleterious	0.33	0.5	NA	NA	0.4	neutral	0.2	neutral	0.22	neutral	6	0.3	neutral	0.65	deleterious	-6	neutral	0.74	deleterious	-0.52	medium_impact	0.33	medium_impact	-1.11	low_impact	0.38	0.8	10.37	8.87	0.33	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4483	4483	C	A	MI.12778	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	14	5	A	D	gCc/gAc	-1.12	0	0	possibly_damaging	0.72	neutral	0.18	neutral	4.12	neutral	-1.46	deleterious	-2.86	medium_impact	2.13	0.87	neutral	0.41	neutral	4.38	24.10	deleterious	0.13	0.4	NA	NA	0.66	disease	0.67	disease	0.71	disease	4	0.86	neutral	0.23	neutral	0	NA	0.75	deleterious	-1.17	low_impact	-0.16	medium_impact	0.65	medium_impact	0.26	0.8	10.37	8.87	0.39	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4483	4483	C	G	MI.12779	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	14	5	A	G	gCc/gGc	-1.12	0	0	benign	0	neutral	0.35	neutral	4.12	neutral	-1.47	deleterious	-2.84	low_impact	1.58	0.91	neutral	0.58	neutral	3.83	23.40	deleterious	0.3	0.45	NA	NA	0.37	neutral	0.49	neutral	0.2	neutral	6	0.65	neutral	0.68	deleterious	-6	neutral	0.69	deleterious	1.95	medium_impact	0.06	medium_impact	0.19	medium_impact	0.58	0.8	10.37	8.87	0.42	N	0.43	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9127	9127	A	C	MI.1278	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	601	201	I	L	Atc/Ctc	-9.36	0	0	benign	0.01	neutral	1	neutral	4.32	neutral	1.11	neutral	-0.73	neutral_impact	-0.22	0.88	neutral	0.73	neutral	-0.36	0.48	neutral	0.39	0.65	NA	NA	0.2	neutral	0.26	neutral	0.19	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.13	neutral	1.14	medium_impact	1.98	high_impact	-1.29	low_impact	0.58	0.9	14.6	19.22	0.3	N	0.66	polymorphism	1	0.02	rs199732761	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4483	4483	C	T	MI.12780	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	14	5	A	V	gCc/gTc	-1.12	0	0	possibly_damaging	0.62	neutral	0.68	neutral	4.22	neutral	-0.07	neutral	1.27	neutral_impact	-0.15	0.86	neutral	0.94	neutral	2.36	18.55	deleterious	0.19	0.45	NA	NA	0.23	neutral	0.16	neutral	0.21	neutral	6	0.54	neutral	0.53	deleterious	-3	neutral	0.68	deleterious	-0.99	medium_impact	0.39	medium_impact	-1.27	low_impact	0.70	0.85	10.37	8.87	0.35	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4485	4485	C	G	MI.12781	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	16	6	Q	E	Caa/Gaa	-6.65	0	0	possibly_damaging	0.56	neutral	0.26	neutral	4.26	neutral	0.36	neutral	-0.73	low_impact	1.42	0.89	neutral	0.26	damaging	2.86	21.70	deleterious	0.36	0.5	NA	NA	0.28	neutral	0.53	disease	0.34	neutral	3	0.73	neutral	0.35	neutral	-3	neutral	0.47	deleterious	-0.89	medium_impact	-0.04	medium_impact	0.05	medium_impact	0.48	0.8	14.7	10.55	0.43	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4485	4485	C	A	MI.12782	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	16	6	Q	K	Caa/Aaa	-6.65	0	0	possibly_damaging	0.74	neutral	0.35	neutral	4.29	neutral	0.63	neutral	-0.4	neutral_impact	-0.88	0.84	neutral	0.46	neutral	2.75	21.10	deleterious	0.34	0.5	NA	NA	0.09	neutral	0.26	neutral	0.2	neutral	6	0.77	neutral	0.31	neutral	-3	neutral	0.53	deleterious	-1.21	low_impact	0.06	medium_impact	-1.89	low_impact	0.29	0.8	14.7	10.55	0.37	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4486	4486	A	C	MI.12783	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	17	6	Q	P	cAa/cCa	-3.42	0	0	probably_damaging	0.94	neutral	0.26	neutral	4.19	neutral	-1.56	neutral	-1.27	neutral_impact	0.26	0.71	neutral	0.21	damaging	3.17	22.70	deleterious	0.06	0.35	NA	NA	0.61	disease	0.66	disease	0.72	disease	4	0.95	neutral	0.16	neutral	-2	neutral	0.73	deleterious	-1.89	low_impact	-0.04	medium_impact	-0.93	medium_impact	0.32	0.8	14.7	10.55	0.27	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4486	4486	A	G	MI.12784	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	17	6	Q	R	cAa/cGa	-3.42	0	0	possibly_damaging	0.74	neutral	0.33	neutral	4.23	neutral	0.09	neutral	-0.57	neutral_impact	0.72	0.85	neutral	0.23	damaging	3.38	22.90	deleterious	0.24	0.45	NA	NA	0.36	neutral	0.47	neutral	0.16	neutral	7	0.78	neutral	0.3	neutral	-3	neutral	0.59	deleterious	-1.21	low_impact	0.04	medium_impact	-0.54	medium_impact	0.12	0.8	14.7	10.55	0.33	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4486	4486	A	T	MI.12785	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	17	6	Q	L	cAa/cTa	-3.42	0	0	possibly_damaging	0.59	neutral	0.92	neutral	4.3	neutral	0.22	neutral	1.38	neutral_impact	-1.15	0.9	neutral	0.95	neutral	1.04	10.91	neutral	0.13	0.4	NA	NA	0.12	neutral	0.13	neutral	0.18	neutral	6	0.54	neutral	0.67	deleterious	-3	neutral	0.46	deleterious	-0.94	medium_impact	0.8	medium_impact	-2.11	low_impact	0.08	0.8	14.7	10.55	0.32	N	0.38	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4487	4487	A	T	MI.12786	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	18	6	Q	H	caA/caT	-2.04	0	0	benign	0.04	neutral	0.54	neutral	4.19	neutral	-1.2	neutral	-0.27	neutral_impact	0.72	0.88	neutral	0.53	neutral	2.91	21.90	deleterious	0.3	0.45	NA	NA	0.18	neutral	0.45	neutral	0.19	neutral	6	0.41	neutral	0.75	deleterious	-6	neutral	0.11	neutral	0.47	medium_impact	0.25	medium_impact	-0.54	medium_impact	0.58	0.8	14.7	10.55	0.34	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4487	4487	A	C	MI.12787	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	18	6	Q	H	caA/caC	-2.04	0	0	benign	0.04	neutral	0.54	neutral	4.19	neutral	-1.2	neutral	-0.27	neutral_impact	0.72	0.88	neutral	0.53	neutral	2.76	21.10	deleterious	0.3	0.45	NA	NA	0.18	neutral	0.45	neutral	0.19	neutral	6	0.41	neutral	0.75	deleterious	-6	neutral	0.11	neutral	0.47	medium_impact	0.25	medium_impact	-0.54	medium_impact	0.58	0.8	14.7	10.55	0.34	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4488	4488	C	A	MI.12788	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	19	7	P	T	Ccc/Acc	-11.71	0	0	possibly_damaging	0.53	neutral	0.43	neutral	4.27	neutral	0.27	neutral	1.9	neutral_impact	-1.05	0.87	neutral	0.96	neutral	2.10	16.84	deleterious	0.16	0.45	0.73	disease	0.06	neutral	0.16	neutral	0.41	neutral	2	0.57	neutral	0.45	neutral	-3	neutral	0.47	deleterious	-0.84	medium_impact	0.14	medium_impact	-2.03	low_impact	0.65	0.8	5.19	7.52	0.45	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4488	4488	C	T	MI.12789	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	19	7	P	S	Ccc/Tcc	-11.71	0	0	possibly_damaging	0.61	neutral	0.52	neutral	4.27	neutral	0.41	neutral	1.36	neutral_impact	-1.06	0.78	neutral	0.97	neutral	2.11	16.89	deleterious	0.22	0.45	0.67	disease	0.06	neutral	0.15	neutral	0.41	neutral	2	0.58	neutral	0.46	neutral	-3	neutral	0.49	deleterious	-0.98	medium_impact	0.23	medium_impact	-2.04	low_impact	0.20	0.8	5.19	7.52	0.42	N	0.61	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9127	9127	A	G	MI.1279	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	601	201	I	V	Atc/Gtc	-9.36	0	0	benign	0	neutral	0.33	neutral	4.3	neutral	0.25	neutral	-0.64	low_impact	1.51	0.95	neutral	0.94	neutral	0.12	3.84	deleterious	0.67	0.75	NA	NA	0.32	neutral	0.38	neutral	0.17	neutral	7	0.67	neutral	0.67	deleterious	-6	neutral	0.16	neutral	2.09	high_impact	0.12	medium_impact	0.2	medium_impact	0.52	0.9	14.6	19.22	0.35	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4488	4488	C	G	MI.12790	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	19	7	P	A	Ccc/Gcc	-11.71	0	0	benign	0.34	neutral	0.55	neutral	4.29	neutral	0.68	neutral	1.16	neutral_impact	-0.56	0.87	neutral	0.82	neutral	1.18	11.64	neutral	0.17	0.45	0.67	disease	0.06	neutral	0.19	neutral	0.39	neutral	2	0.37	neutral	0.61	deleterious	-6	neutral	0.36	neutral	-0.53	medium_impact	0.26	medium_impact	-1.62	low_impact	0.70	0.85	5.19	7.52	0.41	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4489	4489	C	G	MI.12791	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	20	7	P	R	cCc/cGc	-4.11	0	0	possibly_damaging	0.81	neutral	0.34	neutral	4.22	neutral	-0.16	neutral	0.01	low_impact	1.1	0.9	neutral	0.41	neutral	2.00	16.23	deleterious	0.1	0.4	0.64	disease	0.29	neutral	0.52	disease	0.6	disease	2	0.83	neutral	0.27	neutral	-3	neutral	0.63	deleterious	-1.37	low_impact	0.05	medium_impact	-0.22	medium_impact	0.41	0.8	5.19	7.52	0.5	N	0.91	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4489	4489	C	A	MI.12792	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	20	7	P	H	cCc/cAc	-4.11	0	0	probably_damaging	0.93	neutral	0.53	neutral	4.19	neutral	-1.2	neutral	-0.42	neutral_impact	0.55	0.88	neutral	0.45	neutral	2.17	17.32	deleterious	0.11	0.4	0.82	disease	0.15	neutral	0.45	neutral	0.4	neutral	2	0.92	neutral	0.3	neutral	-2	neutral	0.66	deleterious	-1.83	low_impact	0.24	medium_impact	-0.68	medium_impact	0.24	0.8	5.19	7.52	0.33	N	0.90	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4489	4489	C	T	MI.12793	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	20	7	P	L	cCc/cTc	-4.11	0	0	benign	0.01	neutral	0.79	neutral	4.31	neutral	0.26	neutral	2.13	neutral_impact	-1.95	0.95	neutral	0.94	neutral	2.13	17.02	deleterious	0.13	0.4	0.81	disease	0.08	neutral	0.21	neutral	0.38	neutral	2	0.18	neutral	0.89	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.53	medium_impact	-2.79	low_impact	0.70	0.85	5.19	7.52	0.26	N	0.71	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4491	4491	G	A	MI.12794	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	22	8	V	I	Gtc/Atc	-4.11	0	0.03	benign	0	neutral	1	neutral	4.27	neutral	-0.22	neutral	0.07	neutral_impact	-1.42	0.89	neutral	0.96	neutral	-1.27	0.01	neutral	0.42	0.55	0.24	neutral	0.03	neutral	0.14	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	1.87	high_impact	-2.34	low_impact	0.86	0.9	2.59	7.91	0.31	N	0.02	polymorphism	1	0.01	rs201172504	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4491	4491	G	C	MI.12795	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	22	8	V	L	Gtc/Ctc	-4.11	0	0.03	benign	0.02	neutral	0.81	neutral	4.24	neutral	-0.34	neutral	-0.37	neutral_impact	-1.48	0.87	neutral	0.92	neutral	-0.01	2.45	deleterious	0.21	0.45	0.22	neutral	0.34	neutral	0.22	neutral	0.44	neutral	1	0.15	neutral	0.9	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.56	medium_impact	-2.39	low_impact	0.50	0.8	2.59	7.91	0.27	N	0.21	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4491	4491	G	T	MI.12796	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	22	8	V	F	Gtc/Ttc	-4.11	0	0.03	benign	0.2	neutral	0.75	neutral	4.11	neutral	-1.92	neutral	-2.08	neutral_impact	0.07	0.91	neutral	0.79	neutral	1.61	13.93	neutral	0.04	0.35	0.27	neutral	0.71	disease	0.24	neutral	0.51	disease	0	0.15	neutral	0.78	deleterious	-6	neutral	0.27	neutral	-0.25	medium_impact	0.47	medium_impact	-1.09	low_impact	0.31	0.8	2.59	7.91	0.25	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4492	4492	T	A	MI.12797	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	23	8	V	D	gTc/gAc	0.26	0	0	possibly_damaging	0.44	neutral	0.06	neutral	4.05	deleterious	-3.18	deleterious	-4.07	low_impact	1.83	0.85	neutral	0.44	neutral	2.30	18.20	deleterious	0.02	0.35	0.3	neutral	0.72	disease	0.69	disease	0.74	disease	5	0.93	neutral	0.31	neutral	-3	neutral	0.36	neutral	-0.7	medium_impact	-0.46	medium_impact	0.4	medium_impact	0.13	0.8	2.59	7.91	0.35	N	0.51	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4492	4492	T	C	MI.12798	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	23	8	V	A	gTc/gCc	0.26	0	0	benign	0.08	neutral	0.17	neutral	4.15	neutral	-1	neutral	-1.97	low_impact	0.86	0.9	neutral	0.93	neutral	0.29	5.57	deleterious	0.11	0.4	0.29	neutral	0.27	neutral	0.32	neutral	0.44	neutral	1	0.81	neutral	0.55	deleterious	-6	neutral	0.15	neutral	0.17	medium_impact	-0.17	medium_impact	-0.42	medium_impact	0.19	0.8	2.59	7.91	0.55	P	0.33	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4492	4492	T	G	MI.12799	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	23	8	V	G	gTc/gGc	0.26	0	0	benign	0.33	neutral	0.19	neutral	4.07	neutral	-2.88	deleterious	-4.38	low_impact	1.49	0.88	neutral	0.49	neutral	1.68	14.28	neutral	0.03	0.35	0.51	disease	0.55	disease	0.57	disease	0.7	disease	4	0.77	neutral	0.43	neutral	-6	neutral	0.25	neutral	-0.52	medium_impact	-0.14	medium_impact	0.11	medium_impact	0.17	0.8	2.59	7.91	0.39	N	0.49	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8585	8585	C	T	MI.128	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	59	20	A	V	gCa/gTa	-1.49	0	0	benign	0.28	neutral	0.51	neutral	4.67	neutral	-0.42	neutral	1.65	neutral_impact	-0.64	0.87	neutral	0.95	neutral	0.55	7.79	deleterious	0.37	0.65	0.27	neutral	0.3	neutral	0.32	neutral	0.44	neutral	1	0.39	neutral	0.62	deleterious	-6	neutral	0.31	neutral	-0.37	medium_impact	0.3	medium_impact	-1.65	low_impact	0.57	0.9	24.78	23.03	0.28	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9128	9128	T	A	MI.1280	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	602	201	I	N	aTc/aAc	-0.1	0	0.01	benign	0.12	deleterious	0	neutral	4.14	neutral	-2.93	deleterious	-5.13	medium_impact	3.29	0.84	neutral	0.41	neutral	2.72	20.90	deleterious	0.35	0.65	NA	NA	0.76	disease	0.61	disease	0.71	disease	4	1	deleterious	0.44	neutral	1	deleterious	0.34	neutral	0.07	medium_impact	-1.4	low_impact	1.72	medium_impact	0.54	0.9	14.6	19.22	0.34	N	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4494	4494	A	C	MI.12800	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	25	9	I	L	Atc/Ctc	-5.04	0	0	benign	0.03	neutral	1	neutral	4.35	neutral	0.94	neutral	-1.38	neutral_impact	-0.02	0.84	neutral	0.95	neutral	2.11	16.90	deleterious	0.18	0.45	0.17	neutral	0.21	neutral	0.19	neutral	0.37	neutral	3	0.03	neutral	0.99	deleterious	-6	neutral	0.62	deleterious	0.59	medium_impact	1.87	high_impact	-1.16	low_impact	0.51	0.8	0.58	7.5	0.34	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4494	4494	A	T	MI.12801	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	25	9	I	F	Atc/Ttc	-5.04	0	0	benign	0.4	neutral	0.46	neutral	4.17	neutral	-1.31	deleterious	-3.39	neutral_impact	0.46	0.83	neutral	0.63	neutral	3.45	23.00	deleterious	0.14	0.4	0.52	disease	0.33	neutral	0.24	neutral	0.39	neutral	2	0.48	neutral	0.53	deleterious	-6	neutral	0.70	deleterious	-0.64	medium_impact	0.17	medium_impact	-0.76	medium_impact	0.44	0.8	0.58	7.5	0.3	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4494	4494	A	G	MI.12802	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	25	9	I	V	Atc/Gtc	-5.04	0	0	benign	0.08	neutral	0.2	neutral	4.22	neutral	-0.12	neutral	-0.88	medium_impact	2.02	0.88	neutral	0.92	neutral	1.50	13.31	neutral	0.31	0.45	0.34	neutral	0.3	neutral	0.26	neutral	0.48	neutral	0	0.78	neutral	0.56	deleterious	-3	neutral	0.64	deleterious	0.17	medium_impact	-0.13	medium_impact	0.56	medium_impact	0.36	0.8	0.58	7.5	0.51	P	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4495	4495	T	G	MI.12803	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	26	9	I	S	aTc/aGc	-0.2	0	0	benign	0.37	neutral	0.11	neutral	4.12	neutral	-1.88	deleterious	-5.22	low_impact	1.7	0.82	neutral	0.59	neutral	4.03	23.60	deleterious	0.02	0.35	0.51	disease	0.6	disease	0.6	disease	0.52	disease	0	0.87	neutral	0.37	neutral	-6	neutral	0.76	deleterious	-0.59	medium_impact	-0.3	medium_impact	0.29	medium_impact	0.20	0.8	0.58	7.5	0.37	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4495	4495	T	C	MI.12804	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	26	9	I	T	aTc/aCc	-0.2	0	0	benign	0.29	neutral	0.1	neutral	4.14	neutral	-1.51	deleterious	-4.28	medium_impact	2.14	0.89	neutral	0.84	neutral	3.06	22.40	deleterious	0.06	0.35	0.47	neutral	0.5	neutral	0.45	neutral	0.49	neutral	0	0.88	neutral	0.41	neutral	-3	neutral	0.73	deleterious	-0.44	medium_impact	-0.32	medium_impact	0.66	medium_impact	0.17	0.8	0.58	7.5	0.52	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4495	4495	T	A	MI.12805	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	26	9	I	N	aTc/aAc	-0.2	0	0	possibly_damaging	0.71	neutral	0.16	neutral	4.08	deleterious	-3	deleterious	-6.13	medium_impact	2.56	0.88	neutral	0.41	neutral	4.20	23.90	deleterious	0.05	0.35	0.68	disease	0.74	disease	0.6	disease	0.71	disease	4	0.87	neutral	0.23	neutral	0	NA	0.80	deleterious	-1.15	low_impact	-0.19	medium_impact	1.01	medium_impact	0.11	0.8	0.58	7.5	0.4	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4496	4496	C	G	MI.12806	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	27	9	I	M	atC/atG	1.87	0.02	0	benign	0.04	neutral	0.27	neutral	4.14	neutral	-1.02	neutral	-2.38	low_impact	0.86	0.91	neutral	0.79	neutral	1.99	16.17	deleterious	0.17	0.45	0.53	disease	0.34	neutral	0.2	neutral	0.43	neutral	1	0.71	neutral	0.62	deleterious	-6	neutral	0.69	deleterious	0.47	medium_impact	-0.03	medium_impact	-0.42	medium_impact	0.46	0.8	0.58	7.5	0.44	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4496	4496	C	A	MI.12807	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	27	9	I	M	atC/atA	1.87	0.02	0	benign	0.04	neutral	0.27	neutral	4.14	neutral	-1.02	neutral	-2.38	low_impact	0.86	0.91	neutral	0.79	neutral	2.43	19.04	deleterious	0.17	0.45	0.53	disease	0.34	neutral	0.2	neutral	0.43	neutral	1	0.71	neutral	0.62	deleterious	-6	neutral	0.69	deleterious	0.47	medium_impact	-0.03	medium_impact	-0.42	medium_impact	0.46	0.8	0.58	7.5	0.44	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4497	4497	T	G	MI.12808	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	28	10	Y	D	Tac/Gac	-12.17	0	0	possibly_damaging	0.83	deleterious	0.02	neutral	4.14	deleterious	-3.36	deleterious	-3.04	low_impact	1.56	0.85	neutral	0.19	damaging	3.64	23.20	deleterious	0.03	0.35	0.7	disease	0.59	disease	0.65	disease	0.71	disease	4	0.99	deleterious	0.1	neutral	1	deleterious	0.66	deleterious	-1.43	low_impact	-0.73	medium_impact	0.17	medium_impact	0.24	0.8	4.03	8.73	0.33	N	0.85	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4497	4497	T	C	MI.12809	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	28	10	Y	H	Tac/Cac	-12.17	0	0	probably_damaging	0.96	neutral	0.06	neutral	4.15	neutral	-2.6	neutral	-1.79	medium_impact	2.11	0.85	neutral	0.2	damaging	2.22	17.63	deleterious	0.13	0.4	0.62	disease	0.38	neutral	0.61	disease	0.59	disease	2	0.99	deleterious	0.05	neutral	1	deleterious	0.70	deleterious	-2.06	low_impact	-0.46	medium_impact	0.63	medium_impact	0.26	0.8	4.03	8.73	0.26	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9128	9128	T	C	MI.1281	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	602	201	I	T	aTc/aCc	-0.1	0	0.01	benign	0	neutral	0.12	neutral	4.21	neutral	-1.15	deleterious	-3.3	low_impact	1.27	0.96	neutral	0.66	neutral	0.40	6.58	deleterious	0.52	0.65	NA	NA	0.42	neutral	0.4	neutral	0.19	neutral	6	0.88	neutral	0.56	deleterious	-6	neutral	0.16	neutral	2.09	high_impact	-0.2	medium_impact	-0.01	medium_impact	0.57	0.9	14.6	19.22	0.36	N	0.95	polymorphism	1	0.07	rs878867946	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4497	4497	T	A	MI.12810	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	28	10	Y	N	Tac/Aac	-12.17	0	0	possibly_damaging	0.78	neutral	0.05	neutral	4.15	neutral	-2.67	neutral	-2.24	medium_impact	2.11	0.84	neutral	0.25	damaging	3.69	23.30	deleterious	0.05	0.35	0.58	disease	0.46	neutral	0.55	disease	0.6	disease	2	0.97	neutral	0.14	neutral	0	NA	0.57	deleterious	-1.3	low_impact	-0.5	medium_impact	0.63	medium_impact	0.31	0.8	4.03	8.73	0.36	N	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4498	4498	A	G	MI.12811	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	29	10	Y	C	tAc/tGc	-5.5	0	0	probably_damaging	0.97	deleterious	0.02	neutral	4.14	deleterious	-3.08	neutral	-1.54	medium_impact	2.11	0.87	neutral	0.2	damaging	3.27	22.80	deleterious	0.04	0.35	0.6	disease	0.63	disease	0.43	neutral	0.47	neutral	1	1	deleterious	0.03	neutral	5	deleterious	0.70	deleterious	-2.18	low_impact	-0.73	medium_impact	0.63	medium_impact	0.13	0.8	4.03	8.73	0.35	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4498	4498	A	C	MI.12812	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	29	10	Y	S	tAc/tCc	-5.5	0	0	benign	0.12	neutral	0.3	neutral	4.19	neutral	-1.55	neutral	-1.38	neutral_impact	0.06	0.83	neutral	0.96	neutral	1.61	13.93	neutral	0.06	0.35	0.37	neutral	0.29	neutral	0.33	neutral	0.43	neutral	1	0.65	neutral	0.59	deleterious	-6	neutral	0.18	neutral	-0.01	medium_impact	0	medium_impact	-1.09	low_impact	0.31	0.8	4.03	8.73	0.42	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4498	4498	A	T	MI.12813	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	29	10	Y	F	tAc/tTc	-5.5	0	0	possibly_damaging	0.67	neutral	0.78	neutral	4.3	neutral	0.2	neutral	-0.19	neutral_impact	0.23	0.91	neutral	0.87	neutral	1.84	15.20	deleterious	0.31	0.45	0.3	neutral	0.37	neutral	0.23	neutral	0.45	neutral	1	0.61	neutral	0.56	deleterious	-3	neutral	0.50	deleterious	-1.08	low_impact	0.51	medium_impact	-0.95	medium_impact	0.63	0.8	4.03	8.73	0.37	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4500	4500	T	G	MI.12814	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	31	11	S	A	Tct/Gct	-2.73	0	0.01	benign	0.14	neutral	0.18	neutral	4.23	neutral	0.54	neutral	-0.15	low_impact	1.91	0.85	neutral	0.91	neutral	-0.11	1.65	neutral	0.25	0.45	0.27	neutral	0.3	neutral	0.4	neutral	0.44	neutral	1	0.79	neutral	0.52	deleterious	-6	neutral	0.15	neutral	-0.08	medium_impact	-0.16	medium_impact	0.46	medium_impact	0.46	0.8	1.15	8.59	0.46	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4500	4500	T	C	MI.12815	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	31	11	S	P	Tct/Cct	-2.73	0	0.01	benign	0.01	neutral	0.09	neutral	4.11	neutral	-2.21	neutral	-1.64	medium_impact	2.35	0.92	neutral	0.5	neutral	0.68	8.68	deleterious	0.04	0.35	0.58	disease	0.83	disease	0.56	disease	0.75	disease	5	0.91	neutral	0.54	deleterious	-3	neutral	0.28	neutral	1.03	medium_impact	-0.35	medium_impact	0.83	medium_impact	0.26	0.8	1.15	8.59	0.38	N	0.06	polymorphism	1	0.04	rs879007369	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4500	4500	T	A	MI.12816	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	31	11	S	T	Tct/Act	-2.73	0	0.01	benign	0.01	neutral	0.37	neutral	4.2	neutral	-0.56	neutral	0.06	neutral_impact	0.4	0.97	neutral	0.98	neutral	-0.52	0.19	neutral	0.33	0.5	0.25	neutral	0.25	neutral	0.2	neutral	0.44	neutral	1	0.62	neutral	0.68	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.08	medium_impact	-0.81	medium_impact	0.59	0.8	1.15	8.59	0.51	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4501	4501	C	A	MI.12817	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	32	11	S	Y	tCt/tAt	-7.34	0	0	benign	0.31	neutral	0.36	neutral	4.12	neutral	-1.86	neutral	-0.67	medium_impact	2.35	0.9	neutral	0.73	neutral	0.28	5.53	deleterious	0.03	0.35	0.45	neutral	0.72	disease	0.34	neutral	0.51	disease	0	0.57	neutral	0.53	deleterious	-3	neutral	0.32	neutral	-0.48	medium_impact	0.07	medium_impact	0.83	medium_impact	0.25	0.8	1.15	8.59	0.37	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4501	4501	C	G	MI.12818	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	32	11	S	C	tCt/tGt	-7.34	0	0	possibly_damaging	0.85	neutral	0.07	neutral	4.11	neutral	-2.64	neutral	-1.05	medium_impact	2.11	0.8	neutral	0.37	neutral	1.88	15.47	deleterious	0.05	0.35	0.58	disease	0.7	disease	0.43	neutral	0.49	neutral	0	0.96	neutral	0.11	neutral	0	NA	0.63	deleterious	-1.49	low_impact	-0.42	medium_impact	0.63	medium_impact	0.22	0.8	1.15	8.59	0.36	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4501	4501	C	T	MI.12819	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	32	11	S	F	tCt/tTt	-7.34	0	0	benign	0.01	neutral	1	neutral	4.16	neutral	-0.98	neutral	0.08	low_impact	0.98	0.95	neutral	0.96	neutral	-0.28	0.72	neutral	0.06	0.35	0.25	neutral	0.61	disease	0.28	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	1.87	high_impact	-0.32	medium_impact	0.15	0.8	1.15	8.59	0.28	N	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9128	9128	T	G	MI.1282	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	602	201	I	S	aTc/aGc	-0.1	0	0.01	benign	0.04	deleterious	0	neutral	4.2	neutral	-1.49	deleterious	-4.21	medium_impact	2.04	0.81	neutral	0.44	neutral	2.47	19.25	deleterious	0.35	0.65	NA	NA	0.73	disease	0.51	disease	0.53	disease	1	1	deleterious	0.48	deleterious	1	deleterious	0.24	neutral	0.55	medium_impact	-1.4	low_impact	0.65	medium_impact	0.56	0.9	14.6	19.22	0.35	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4503	4503	A	T	MI.12820	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	34	12	T	S	Acc/Tcc	-3.65	0	0	possibly_damaging	0.72	neutral	0.46	neutral	4.2	neutral	-0.86	deleterious	-3.61	low_impact	0.91	0.83	neutral	0.79	neutral	0.07	3.26	deleterious	0.35	0.5	0.24	neutral	0.07	neutral	0.16	neutral	0.27	neutral	5	0.71	neutral	0.37	neutral	-3	neutral	0.50	deleterious	-1.17	low_impact	0.17	medium_impact	-0.38	medium_impact	0.66	0.8	2.59	7.45	0.45	N	0.41	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4503	4503	A	G	MI.12821	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	34	12	T	A	Acc/Gcc	-3.65	0	0	benign	0.11	neutral	0.51	neutral	4.16	neutral	-0.69	deleterious	-4.51	medium_impact	2.02	0.94	neutral	0.6	neutral	1.79	14.94	neutral	0.24	0.45	0.48	neutral	0.57	disease	0.56	disease	0.66	disease	3	0.41	neutral	0.7	deleterious	-3	neutral	0.23	neutral	0.03	medium_impact	0.22	medium_impact	0.56	medium_impact	0.29	0.8	2.59	7.45	0.31	N	0.75	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4503	4503	A	C	MI.12822	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	34	12	T	P	Acc/Ccc	-3.65	0	0	probably_damaging	0.95	neutral	0.2	neutral	4.07	deleterious	-3.07	deleterious	-5.42	medium_impact	3.02	0.75	neutral	0.37	neutral	2.12	16.96	deleterious	0.05	0.35	0.74	disease	0.92	disease	0.68	disease	0.79	disease	6	0.97	neutral	0.13	neutral	1	deleterious	0.84	deleterious	-1.97	low_impact	-0.13	medium_impact	1.4	medium_impact	0.35	0.8	2.59	7.45	0.29	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4504	4504	C	A	MI.12823	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	35	12	T	N	aCc/aAc	4.4	0.99	0	probably_damaging	0.95	neutral	0.31	neutral	4.09	neutral	-2.05	deleterious	-4.52	medium_impact	2	0.85	neutral	0.57	neutral	1.74	14.62	neutral	0.24	0.45	0.55	disease	0.85	disease	0.42	neutral	0.71	disease	4	0.96	neutral	0.18	neutral	1	deleterious	0.76	deleterious	-1.97	low_impact	0.02	medium_impact	0.54	medium_impact	0.58	0.8	2.59	7.45	0.52	N	0.83	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4504	4504	C	T	MI.12824	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	35	12	T	I	aCc/aTc	4.4	0.99	0	probably_damaging	0.91	neutral	0.41	neutral	4.17	neutral	-0.53	deleterious	-5.37	low_impact	1.92	0.88	neutral	0.55	neutral	1.96	15.93	deleterious	0.13	0.4	0.59	disease	0.82	disease	0.55	disease	0.75	disease	5	0.91	neutral	0.25	neutral	-2	neutral	0.73	deleterious	-1.72	low_impact	0.12	medium_impact	0.47	medium_impact	0.62	0.8	2.59	7.45	0.54	P	0.83	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4504	4504	C	G	MI.12825	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	35	12	T	S	aCc/aGc	4.4	0.99	0	possibly_damaging	0.72	neutral	0.46	neutral	4.2	neutral	-0.86	deleterious	-3.61	low_impact	0.91	0.83	neutral	0.79	neutral	-0.26	0.80	neutral	0.35	0.5	0.24	neutral	0.07	neutral	0.16	neutral	0.27	neutral	5	0.71	neutral	0.37	neutral	-3	neutral	0.50	deleterious	-1.17	low_impact	0.17	medium_impact	-0.38	medium_impact	0.66	0.8	2.59	7.45	0.55	P	0.41	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4506	4506	A	G	MI.12826	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	37	13	I	V	Atc/Gtc	-3.88	0	0	benign	0.01	neutral	0.28	neutral	4.21	neutral	-0.04	neutral	-0.22	neutral_impact	0.62	0.98	neutral	0.97	neutral	-0.70	0.07	neutral	0.56	0.6	0.38	neutral	0.31	neutral	0.35	neutral	0.45	neutral	1	0.71	neutral	0.64	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	-0.02	medium_impact	-0.62	medium_impact	0.38	0.8	0.29	9.03	0.45	N	0.65	polymorphism	1	0.01	rs11510099	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4506	4506	A	C	MI.12827	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	37	13	I	L	Atc/Ctc	-3.88	0	0	benign	0.08	neutral	1	neutral	4.46	neutral	1.12	neutral	-0.32	neutral_impact	-0.9	0.88	neutral	0.93	neutral	-1.03	0.01	neutral	0.24	0.45	0.22	neutral	0.16	neutral	0.27	neutral	0.24	neutral	5	0.08	neutral	0.96	deleterious	-6	neutral	0.14	neutral	0.17	medium_impact	1.87	high_impact	-1.9	low_impact	0.55	0.8	0.29	9.03	0.3	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4506	4506	A	T	MI.12828	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	37	13	I	F	Atc/Ttc	-3.88	0	0	possibly_damaging	0.58	neutral	0.27	neutral	4.13	neutral	-1.1	deleterious	-2.68	medium_impact	2.02	0.86	neutral	0.5	neutral	2.02	16.36	deleterious	0.22	0.45	0.59	disease	0.8	disease	0.65	disease	0.78	disease	6	0.73	neutral	0.35	neutral	0	NA	0.63	deleterious	-0.93	medium_impact	-0.03	medium_impact	0.56	medium_impact	0.55	0.8	0.29	9.03	0.34	N	0.57	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4507	4507	T	G	MI.12829	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	38	13	I	S	aTc/aGc	-3.42	0	0	possibly_damaging	0.65	neutral	0.35	neutral	4.11	neutral	-1.44	deleterious	-4.03	medium_impact	2.12	0.88	neutral	0.49	neutral	2.30	18.17	deleterious	0.04	0.35	0.52	disease	0.78	disease	0.6	disease	0.77	disease	5	0.71	neutral	0.35	neutral	0	NA	0.59	deleterious	-1.04	low_impact	0.06	medium_impact	0.64	medium_impact	0.20	0.8	0.29	9.03	0.33	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9129	9129	C	G	MI.1283	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	603	201	I	M	atC/atG	3.83	0.4	0	benign	0.01	neutral	0.42	neutral	4.21	neutral	-0.59	neutral	-1.25	low_impact	1.09	0.88	neutral	0.92	neutral	0.42	6.77	deleterious	0.55	0.65	NA	NA	0.39	neutral	0.34	neutral	0.17	neutral	7	0.57	neutral	0.71	deleterious	-6	neutral	0.16	neutral	1.14	medium_impact	0.21	medium_impact	-0.16	medium_impact	0.76	0.9	14.6	19.22	0.36	N	0.28	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4507	4507	T	A	MI.12830	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	38	13	I	N	aTc/aAc	-3.42	0	0	possibly_damaging	0.85	deleterious	0.04	neutral	4.07	neutral	-2.91	deleterious	-4.97	medium_impact	2.27	0.87	neutral	0.43	neutral	3.87	23.50	deleterious	0.08	0.35	0.75	disease	0.85	disease	0.63	disease	0.8	disease	6	0.98	neutral	0.1	neutral	4	deleterious	0.75	deleterious	-1.49	low_impact	-0.56	medium_impact	0.77	medium_impact	0.19	0.8	0.29	9.03	0.41	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4507	4507	T	C	MI.12831	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	38	13	I	T	aTc/aCc	-3.42	0	0	benign	0.36	neutral	0.27	neutral	4.12	neutral	-1.21	deleterious	-3	low_impact	1.66	0.91	neutral	0.66	neutral	1.29	12.24	neutral	0.13	0.4	0.38	neutral	0.54	disease	0.58	disease	0.7	disease	4	0.68	neutral	0.46	neutral	-6	neutral	0.42	neutral	-0.57	medium_impact	-0.03	medium_impact	0.25	medium_impact	0.28	0.8	0.29	9.03	0.39	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4508	4508	C	G	MI.12832	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	39	13	I	M	atC/atG	5.78	0.87	0	benign	0.05	neutral	0.32	neutral	4.16	neutral	-1.18	neutral	-0.71	neutral_impact	0.16	0.95	neutral	0.91	neutral	0.11	3.73	deleterious	0.35	0.5	0.59	disease	0.49	neutral	0.31	neutral	0.56	disease	1	0.65	neutral	0.64	deleterious	-6	neutral	0.23	neutral	0.37	medium_impact	0.03	medium_impact	-1.01	low_impact	0.52	0.8	0.29	9.03	0.43	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4508	4508	C	A	MI.12833	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	39	13	I	M	atC/atA	5.78	0.87	0	benign	0.05	neutral	0.32	neutral	4.16	neutral	-1.18	neutral	-0.71	neutral_impact	0.16	0.95	neutral	0.91	neutral	0.54	7.75	deleterious	0.35	0.5	0.59	disease	0.49	neutral	0.31	neutral	0.56	disease	1	0.65	neutral	0.64	deleterious	-6	neutral	0.23	neutral	0.37	medium_impact	0.03	medium_impact	-1.01	low_impact	0.52	0.8	0.29	9.03	0.43	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4509	4509	T	A	MI.12834	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	40	14	F	I	Ttt/Att	-2.73	0	0	benign	0	neutral	0.57	neutral	4.23	neutral	0.05	neutral	0.75	neutral_impact	-0.88	0.97	neutral	0.98	neutral	1.38	12.68	neutral	0.15	0.4	0.19	neutral	0.14	neutral	0.27	neutral	0.26	neutral	5	0.42	neutral	0.79	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	0.28	medium_impact	-1.89	low_impact	0.56	0.8	4.9	7.47	0.34	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4509	4509	T	G	MI.12835	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	40	14	F	V	Ttt/Gtt	-2.73	0	0	benign	0.03	neutral	0.55	neutral	4.23	neutral	0.11	neutral	0.27	neutral_impact	0.23	0.91	neutral	0.94	neutral	2.36	18.57	deleterious	0.13	0.4	0.22	neutral	0.42	neutral	0.43	neutral	0.43	neutral	1	0.41	neutral	0.76	deleterious	-6	neutral	0.12	neutral	0.59	medium_impact	0.26	medium_impact	-0.95	medium_impact	0.29	0.8	4.9	7.47	0.31	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4509	4509	T	C	MI.12836	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	40	14	F	L	Ttt/Ctt	-2.73	0	0	benign	0	neutral	1	neutral	4.3	neutral	0.56	neutral	0.32	neutral_impact	0.3	0.98	neutral	0.96	neutral	1.61	13.89	neutral	0.2	0.45	0.23	neutral	0.18	neutral	0.29	neutral	0.25	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	1.87	high_impact	-0.89	medium_impact	0.53	0.8	4.9	7.47	0.29	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4510	4510	T	C	MI.12837	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	41	14	F	S	tTt/tCt	-2.73	0	0	benign	0.21	neutral	0.31	neutral	4.12	neutral	-1.27	neutral	-2.21	low_impact	1.12	0.85	neutral	0.63	neutral	3.98	23.60	deleterious	0.06	0.35	0.43	neutral	0.34	neutral	0.42	neutral	0.45	neutral	1	0.63	neutral	0.55	deleterious	-6	neutral	0.30	neutral	-0.27	medium_impact	0.02	medium_impact	-0.2	medium_impact	0.23	0.8	4.9	7.47	0.36	N	0.48	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4510	4510	T	A	MI.12838	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	41	14	F	Y	tTt/tAt	-2.73	0	0	possibly_damaging	0.47	neutral	0.56	neutral	4.09	neutral	-2.1	neutral	-1.14	medium_impact	2.44	0.91	neutral	0.55	neutral	3.91	23.50	deleterious	0.23	0.45	0.51	disease	0.33	neutral	0.42	neutral	0.33	neutral	3	0.44	neutral	0.55	deleterious	0	NA	0.48	deleterious	-0.75	medium_impact	0.27	medium_impact	0.91	medium_impact	0.57	0.8	4.9	7.47	0.41	N	0.33	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4510	4510	T	G	MI.12839	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	41	14	F	C	tTt/tGt	-2.73	0	0	possibly_damaging	0.77	neutral	0.11	neutral	4.07	neutral	-2.83	neutral	-1.93	low_impact	1.9	0.83	neutral	0.42	neutral	3.87	23.50	deleterious	0.09	0.35	0.63	disease	0.6	disease	0.41	neutral	0.48	neutral	0	0.92	neutral	0.17	neutral	-3	neutral	0.60	deleterious	-1.28	low_impact	-0.3	medium_impact	0.46	medium_impact	0.15	0.8	4.9	7.47	0.36	N	0.48	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9129	9129	C	A	MI.1284	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	603	201	I	M	atC/atA	3.83	0.4	0	benign	0.01	neutral	0.42	neutral	4.21	neutral	-0.59	neutral	-1.25	low_impact	1.09	0.88	neutral	0.92	neutral	0.89	10.01	neutral	0.55	0.65	NA	NA	0.39	neutral	0.34	neutral	0.17	neutral	7	0.57	neutral	0.71	deleterious	-6	neutral	0.16	neutral	1.14	medium_impact	0.21	medium_impact	-0.16	medium_impact	0.76	0.9	14.6	19.22	0.36	N	0.28	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4511	4511	T	G	MI.12840	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	42	14	F	L	ttT/ttG	1.41	0	0	benign	0	neutral	1	neutral	4.3	neutral	0.56	neutral	0.32	neutral_impact	0.3	0.98	neutral	0.96	neutral	1.91	15.64	deleterious	0.2	0.45	0.23	neutral	0.18	neutral	0.29	neutral	0.25	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	1.87	high_impact	-0.89	medium_impact	0.53	0.8	4.9	7.47	0.34	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4511	4511	T	A	MI.12841	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	42	14	F	L	ttT/ttA	1.41	0	0	benign	0	neutral	1	neutral	4.3	neutral	0.56	neutral	0.32	neutral_impact	0.3	0.98	neutral	0.96	neutral	2.04	16.46	deleterious	0.2	0.45	0.23	neutral	0.18	neutral	0.29	neutral	0.25	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	1.87	high_impact	-0.89	medium_impact	0.53	0.8	4.9	7.47	0.35	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4512	4512	G	C	MI.12842	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	43	15	A	P	Gca/Cca	-14.94	0	0	possibly_damaging	0.65	deleterious	0.04	neutral	4.05	deleterious	-4.1	neutral	-1.73	low_impact	0.9	0.78	neutral	0.36	neutral	3.24	22.80	deleterious	0.06	0.35	0.74	disease	0.81	disease	0.72	disease	0.79	disease	6	0.96	neutral	0.2	neutral	1	deleterious	0.64	deleterious	-1.04	low_impact	-0.56	medium_impact	-0.39	medium_impact	0.54	0.8	2.31	7.56	0.29	N	0.23	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4512	4512	G	T	MI.12843	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	43	15	A	S	Gca/Tca	-14.94	0	0	benign	0.2	neutral	0.25	neutral	4.11	neutral	-2.1	neutral	0.27	neutral_impact	-1.38	0.79	neutral	0.96	neutral	-0.09	1.80	neutral	0.23	0.45	0.27	neutral	0.32	neutral	0.31	neutral	0.45	neutral	1	0.7	neutral	0.53	deleterious	-6	neutral	0.24	neutral	-0.25	medium_impact	-0.06	medium_impact	-2.31	low_impact	0.50	0.8	2.31	7.56	0.39	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4512	4512	G	A	MI.12844	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	43	15	A	T	Gca/Aca	-14.94	0	0	benign	0.01	neutral	0.18	neutral	4.14	neutral	-1.52	neutral	0.15	neutral_impact	-0.7	0.95	neutral	0.97	neutral	0.63	8.38	deleterious	0.21	0.45	0.41	neutral	0.19	neutral	0.28	neutral	0.36	neutral	3	0.82	neutral	0.59	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	-0.16	medium_impact	-1.73	low_impact	0.70	0.85	2.31	7.56	0.5	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4513	4513	C	T	MI.12845	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	44	15	A	V	gCa/gTa	-8.72	0	0	benign	0.2	neutral	0.14	neutral	4.18	neutral	-0.89	neutral	0.14	neutral_impact	-0.08	0.86	neutral	0.82	neutral	1.12	11.34	neutral	0.18	0.45	0.4	neutral	0.48	neutral	0.37	neutral	0.47	neutral	1	0.84	neutral	0.47	deleterious	-6	neutral	0.27	neutral	-0.25	medium_impact	-0.23	medium_impact	-1.21	low_impact	0.63	0.8	2.31	7.56	0.44	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4513	4513	C	A	MI.12846	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	44	15	A	E	gCa/gAa	-8.72	0	0	benign	0.36	deleterious	0.03	neutral	4.06	deleterious	-3.52	neutral	-1.49	low_impact	1.45	0.89	neutral	0.56	neutral	2.42	18.95	deleterious	0.04	0.35	0.56	disease	0.74	disease	0.71	disease	0.77	disease	5	0.97	neutral	0.34	neutral	-2	neutral	0.49	deleterious	-0.57	medium_impact	-0.63	medium_impact	0.08	medium_impact	0.35	0.8	2.31	7.56	0.43	N	0.27	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4513	4513	C	G	MI.12847	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	44	15	A	G	gCa/gGa	-8.72	0	0	benign	0.26	neutral	0.14	neutral	4.09	neutral	-2.45	neutral	-2.05	neutral_impact	0.75	0.88	neutral	0.56	neutral	1.90	15.60	deleterious	0.25	0.45	0.67	disease	0.48	neutral	0.54	disease	0.66	disease	3	0.83	neutral	0.44	neutral	-6	neutral	0.37	neutral	-0.38	medium_impact	-0.23	medium_impact	-0.51	medium_impact	0.66	0.8	2.31	7.56	0.39	N	0.30	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4515	4515	G	T	MI.12848	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	46	16	G	C	Ggc/Tgc	-0.89	0	0	probably_damaging	1	neutral	0.18	neutral	3.69	deleterious	-5.25	deleterious	-7.92	high_impact	3.94	0.75	neutral	0.07	damaging	3.93	23.50	deleterious	0.03	0.35	0.84	disease	0.87	disease	0.76	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	-0.16	medium_impact	2.17	high_impact	0.19	0.8	NA	NA	0.39	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4515	4515	G	A	MI.12849	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	46	16	G	S	Ggc/Agc	-0.89	0	0	probably_damaging	1	neutral	0.51	neutral	3.78	deleterious	-3.13	deleterious	-5.1	medium_impact	2	0.82	neutral	0.57	neutral	3.90	23.50	deleterious	0.07	0.35	0.18	neutral	0.81	disease	0.68	disease	0.64	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.22	medium_impact	0.54	medium_impact	0.64	0.8	NA	NA	0.3	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9130	9130	C	A	MI.1285	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	604	202	L	M	Cta/Ata	-14.91	0	0	probably_damaging	1	neutral	0.09	neutral	3.3	deleterious	-3.82	neutral	-1.79	medium_impact	3.44	0.38	damaging	0.62	neutral	3.82	23.40	deleterious	0.26	0.65	NA	NA	0.63	disease	0.64	disease	0.66	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	-0.28	medium_impact	1.85	medium_impact	0.49	0.9	49.56	8.88	0.52	P	0.96	polymorphism	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4515	4515	G	C	MI.12850	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	46	16	G	R	Ggc/Cgc	-0.89	0	0	probably_damaging	1	neutral	0.35	neutral	3.71	deleterious	-4.3	deleterious	-7.04	high_impact	4.29	0.79	neutral	0.07	damaging	3.75	23.30	deleterious	0.03	0.35	0.45	neutral	0.88	disease	0.85	disease	0.84	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	0.06	medium_impact	2.47	high_impact	0.57	0.8	NA	NA	0.43	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4516	4516	G	A	MI.12851	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	47	16	G	D	gGc/gAc	5.09	1	0	probably_damaging	1	neutral	0.2	neutral	3.7	deleterious	-4.79	deleterious	-6.13	high_impact	4.29	0.8	neutral	0.08	damaging	3.63	23.20	deleterious	0.03	0.35	0.46	neutral	0.88	disease	0.84	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	-0.13	medium_impact	2.47	high_impact	0.15	0.8	NA	NA	0.62	P	0.95	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4516	4516	G	T	MI.12852	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	47	16	G	V	gGc/gTc	5.09	1	0	probably_damaging	1	neutral	0.52	neutral	3.77	neutral	-2.95	deleterious	-7.96	high_impact	3.73	0.65	neutral	0.08	damaging	3.56	23.10	deleterious	0.03	0.35	0.55	disease	0.87	disease	0.78	disease	0.8	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.23	medium_impact	2	medium_impact	0.15	0.8	NA	NA	0.61	P	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4516	4516	G	C	MI.12853	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	47	16	G	A	gGc/gCc	5.09	1	0	probably_damaging	1	neutral	0.52	neutral	3.78	neutral	-2.59	deleterious	-5.22	high_impact	3.59	0.75	neutral	0.1	damaging	2.91	21.90	deleterious	0.09	0.35	0.4	neutral	0.63	disease	0.72	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.23	medium_impact	1.88	medium_impact	0.37	0.8	NA	NA	0.56	P	0.74	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4518	4518	A	G	MI.12854	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	49	17	T	A	Aca/Gca	-7.34	0	0	probably_damaging	1	neutral	0.51	neutral	4.15	neutral	0.14	deleterious	-4.57	medium_impact	3.25	0.9	neutral	0.13	damaging	3.24	22.80	deleterious	0.19	0.45	0.31	neutral	0.65	disease	0.67	disease	0.68	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.22	medium_impact	1.59	medium_impact	0.44	0.8	2.31	7.6	0.33	N	0.79	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4518	4518	A	T	MI.12855	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	49	17	T	S	Aca/Tca	-7.34	0	0	probably_damaging	1	neutral	0.52	neutral	4.11	neutral	-0.66	deleterious	-3.65	medium_impact	2.58	0.92	neutral	0.32	neutral	3.02	22.30	deleterious	0.34	0.5	0.4	neutral	0.67	disease	0.6	disease	0.49	neutral	0	1	deleterious	0.26	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.23	medium_impact	1.03	medium_impact	0.56	0.8	2.31	7.6	0.35	N	0.54	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4518	4518	A	C	MI.12856	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	49	17	T	P	Aca/Cca	-7.34	0	0	probably_damaging	1	neutral	0.22	neutral	4.03	neutral	-2.83	deleterious	-5.48	medium_impact	2.88	0.91	neutral	0.73	neutral	2.19	17.47	deleterious	0.04	0.35	0.43	neutral	0.82	disease	0.62	disease	0.55	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.1	medium_impact	1.28	medium_impact	0.37	0.8	2.31	7.6	0.43	N	0.50	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4519	4519	C	T	MI.12857	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	50	17	T	M	aCa/aTa	2.33	0.94	0	probably_damaging	1	neutral	0.27	neutral	4.24	neutral	1.34	deleterious	-5.48	medium_impact	3.32	0.91	neutral	0.11	damaging	3.80	23.40	deleterious	0.12	0.4	0.79	disease	0.81	disease	0.7	disease	0.76	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.03	medium_impact	1.65	medium_impact	0.52	0.8	2.31	7.6	0.45	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4519	4519	C	A	MI.12858	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	50	17	T	K	aCa/aAa	2.33	0.94	0	probably_damaging	1	neutral	0.28	neutral	4.04	neutral	-2.09	deleterious	-5.48	high_impact	4.29	0.9	neutral	0.1	damaging	4.18	23.80	deleterious	0.07	0.35	0.48	neutral	0.86	disease	0.8	disease	0.8	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.02	medium_impact	2.47	high_impact	0.40	0.8	2.31	7.6	0.62	P	0.95	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4521	4521	C	T	MI.12859	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	52	18	L	F	Ctc/Ttc	-11.48	0	0	benign	0.04	neutral	0.8	neutral	4.01	neutral	-2.24	neutral	-2.07	low_impact	1.34	0.98	neutral	0.89	neutral	2.52	19.61	deleterious	0.22	0.45	0.19	neutral	0.57	disease	0.33	neutral	0.48	neutral	0	0.13	neutral	0.88	deleterious	-6	neutral	0.12	neutral	0.47	medium_impact	0.54	medium_impact	-0.02	medium_impact	0.65	0.8	4.61	7.28	0.32	N	0.16	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9130	9130	C	G	MI.1286	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	604	202	L	V	Cta/Gta	-14.91	0	0	probably_damaging	0.99	deleterious	0	neutral	3.3	deleterious	-3.68	deleterious	-2.69	high_impact	4.13	0.31	damaging	0.48	neutral	3.50	23.10	deleterious	0.28	0.65	NA	NA	0.67	disease	0.66	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-1.4	low_impact	2.44	high_impact	0.49	0.9	49.56	8.88	0.6	P	0.87	polymorphism	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4521	4521	C	A	MI.12860	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	52	18	L	I	Ctc/Atc	-11.48	0	0	benign	0.03	neutral	0.6	neutral	4.11	neutral	-1.18	neutral	-0.75	neutral_impact	0.31	0.97	neutral	0.95	neutral	1.62	13.98	neutral	0.37	0.5	0.4	neutral	0.16	neutral	0.16	neutral	0.26	neutral	5	0.36	neutral	0.79	deleterious	-6	neutral	0.14	neutral	0.59	medium_impact	0.31	medium_impact	-0.88	medium_impact	0.63	0.8	4.61	7.28	0.45	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4521	4521	C	G	MI.12861	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	52	18	L	V	Ctc/Gtc	-11.48	0	0	benign	0.18	neutral	0.64	neutral	4.08	neutral	-1.22	neutral	-0.9	low_impact	1.29	0.89	neutral	0.96	neutral	1.39	12.72	neutral	0.31	0.45	0.36	neutral	0.31	neutral	0.24	neutral	0.46	neutral	1	0.24	neutral	0.73	deleterious	-6	neutral	0.27	neutral	-0.19	medium_impact	0.35	medium_impact	-0.06	medium_impact	0.66	0.8	4.61	7.28	0.38	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4522	4522	T	G	MI.12862	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	53	18	L	R	cTc/cGc	-0.89	0	0	possibly_damaging	0.81	neutral	0.35	neutral	3.95	deleterious	-3.83	deleterious	-3.07	medium_impact	3.09	0.82	neutral	0.43	neutral	3.92	23.50	deleterious	0.02	0.35	0.74	disease	0.81	disease	0.71	disease	0.79	disease	6	0.83	neutral	0.27	neutral	0	NA	0.73	deleterious	-1.37	low_impact	0.06	medium_impact	1.46	medium_impact	0.25	0.8	4.61	7.28	0.31	N	0.76	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4522	4522	T	C	MI.12863	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	53	18	L	P	cTc/cCc	-0.89	0	0	possibly_damaging	0.86	neutral	0.2	neutral	3.94	deleterious	-4.45	deleterious	-3.68	medium_impact	2.54	0.71	neutral	0.36	neutral	3.71	23.30	deleterious	0.02	0.35	0.8	disease	0.83	disease	0.71	disease	0.81	disease	6	0.91	neutral	0.17	neutral	0	NA	0.77	deleterious	-1.52	low_impact	-0.13	medium_impact	0.99	medium_impact	0.38	0.8	4.61	7.28	0.28	N	0.85	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4522	4522	T	A	MI.12864	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	53	18	L	H	cTc/cAc	-0.89	0	0	probably_damaging	0.93	neutral	0.55	neutral	3.95	deleterious	-4.21	deleterious	-3.82	medium_impact	3.09	0.84	neutral	0.47	neutral	3.99	23.60	deleterious	0.04	0.35	0.8	disease	0.56	disease	0.57	disease	0.72	disease	4	0.92	neutral	0.31	neutral	1	deleterious	0.72	deleterious	-1.83	low_impact	0.26	medium_impact	1.46	medium_impact	0.23	0.8	4.61	7.28	0.26	N	0.72	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4524	4524	A	G	MI.12865	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	55	19	I	V	Atc/Gtc	-2.73	0	0	benign	0.42	neutral	0.48	neutral	4.21	neutral	0.36	neutral	-0.73	medium_impact	2.31	0.93	neutral	0.79	neutral	1.55	13.60	neutral	0.59	0.65	0.49	neutral	0.45	neutral	0.38	neutral	0.43	neutral	1	0.47	neutral	0.53	deleterious	-3	neutral	0.31	neutral	-0.67	medium_impact	0.19	medium_impact	0.8	medium_impact	0.46	0.8	0.86	7.07	0.37	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4524	4524	A	T	MI.12866	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	55	19	I	F	Atc/Ttc	-2.73	0	0	probably_damaging	0.92	neutral	0.29	neutral	4.08	neutral	-0.8	deleterious	-3.23	medium_impact	2.66	0.84	neutral	0.4	neutral	3.52	23.10	deleterious	0.15	0.4	0.67	disease	0.85	disease	0.63	disease	0.71	disease	4	0.94	neutral	0.19	neutral	1	deleterious	0.72	deleterious	-1.77	low_impact	-0.01	medium_impact	1.1	medium_impact	0.59	0.8	0.86	7.07	0.31	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4524	4524	A	C	MI.12867	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	55	19	I	L	Atc/Ctc	-2.73	0	0	benign	0.42	neutral	0.98	neutral	4.3	neutral	1.01	neutral	-1.18	low_impact	1.16	0.91	neutral	0.93	neutral	1.75	14.69	neutral	0.27	0.45	0.33	neutral	0.4	neutral	0.25	neutral	0.44	neutral	1	0.39	neutral	0.78	deleterious	-6	neutral	0.43	neutral	-0.67	medium_impact	1.15	medium_impact	-0.17	medium_impact	0.59	0.8	0.86	7.07	0.3	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4525	4525	T	A	MI.12868	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	56	19	I	N	aTc/aAc	-0.2	0	0	possibly_damaging	0.9	neutral	0.07	neutral	3.99	neutral	-2.63	deleterious	-5.78	high_impact	3.98	0.89	neutral	0.47	neutral	4.22	23.90	deleterious	0.07	0.35	0.75	disease	0.87	disease	0.62	disease	0.71	disease	4	0.97	neutral	0.09	neutral	1	deleterious	0.75	deleterious	-1.67	low_impact	-0.42	medium_impact	2.21	high_impact	0.45	0.8	0.86	7.07	0.52	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4525	4525	T	G	MI.12869	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	56	19	I	S	aTc/aGc	-0.2	0	0	possibly_damaging	0.54	neutral	0.56	neutral	4.02	neutral	-1.91	deleterious	-4.87	high_impact	3.63	0.84	neutral	0.47	neutral	4.02	23.60	deleterious	0.02	0.35	0.34	neutral	0.84	disease	0.62	disease	0.71	disease	4	0.5	neutral	0.51	deleterious	1	deleterious	0.53	deleterious	-0.86	medium_impact	0.27	medium_impact	1.91	medium_impact	0.37	0.8	0.86	7.07	0.29	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9131	9131	T	C	MI.1287	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	605	202	L	P	cTa/cCa	0.13	0	0	probably_damaging	1	deleterious	0	neutral	3.25	deleterious	-6.45	deleterious	-6.3	high_impact	4.13	0.19	damaging	0.47	neutral	4.01	23.60	deleterious	0.15	0.65	NA	NA	0.86	disease	0.72	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.6	low_impact	-1.4	low_impact	2.44	high_impact	0.49	0.9	49.56	8.88	0.9	P	1.00	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4525	4525	T	C	MI.12870	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	56	19	I	T	aTc/aCc	-0.2	0	0	benign	0.06	neutral	0.31	neutral	4.04	neutral	-1.41	deleterious	-3.88	medium_impact	2.08	0.92	neutral	0.94	neutral	3.09	22.50	deleterious	0.06	0.35	0.5	neutral	0.65	disease	0.41	neutral	0.47	neutral	1	0.66	neutral	0.63	deleterious	-3	neutral	0.23	neutral	0.3	medium_impact	0.02	medium_impact	0.61	medium_impact	0.26	0.8	0.86	7.07	0.42	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4526	4526	C	A	MI.12871	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	57	19	I	M	atC/atA	4.63	0.65	0	probably_damaging	0.95	neutral	0.37	neutral	4.07	neutral	-0.78	neutral	-1.98	low_impact	1.72	0.89	neutral	0.93	neutral	2.29	18.13	deleterious	0.31	0.45	0.63	disease	0.51	disease	0.31	neutral	0.48	neutral	0	0.95	neutral	0.21	neutral	-2	neutral	0.68	deleterious	-1.97	low_impact	0.08	medium_impact	0.3	medium_impact	0.55	0.8	0.86	7.07	0.45	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4526	4526	C	G	MI.12872	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	57	19	I	M	atC/atG	4.63	0.65	0	probably_damaging	0.95	neutral	0.37	neutral	4.07	neutral	-0.78	neutral	-1.98	low_impact	1.72	0.89	neutral	0.93	neutral	1.85	15.28	deleterious	0.31	0.45	0.63	disease	0.51	disease	0.31	neutral	0.48	neutral	0	0.95	neutral	0.21	neutral	-2	neutral	0.68	deleterious	-1.97	low_impact	0.08	medium_impact	0.3	medium_impact	0.55	0.8	0.86	7.07	0.45	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4527	4527	A	C	MI.12873	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	58	20	T	P	Aca/Cca	-8.95	0	0	probably_damaging	0.95	neutral	0.2	neutral	4.06	neutral	-2.89	deleterious	-3.16	medium_impact	3.37	0.81	neutral	0.4	neutral	1.64	14.05	neutral	0.04	0.35	0.75	disease	0.86	disease	0.77	disease	0.78	disease	6	0.97	neutral	0.13	neutral	1	deleterious	0.78	deleterious	-1.97	low_impact	-0.13	medium_impact	1.69	medium_impact	0.32	0.8	1.15	11.16	0.39	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4527	4527	A	G	MI.12874	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	58	20	T	A	Aca/Gca	-8.95	0	0	benign	0.11	neutral	0.48	neutral	4.17	neutral	0.3	neutral	-1.48	low_impact	0.89	0.93	neutral	0.8	neutral	0.23	5.00	deleterious	0.19	0.45	0.39	neutral	0.56	disease	0.55	disease	0.46	neutral	1	0.44	neutral	0.69	deleterious	-6	neutral	0.19	neutral	0.03	medium_impact	0.19	medium_impact	-0.4	medium_impact	0.49	0.8	1.15	11.16	0.3	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4527	4527	A	T	MI.12875	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	58	20	T	S	Aca/Tca	-8.95	0	0	possibly_damaging	0.72	neutral	0.55	neutral	4.15	neutral	-0.58	neutral	-2.29	low_impact	1.22	0.91	neutral	0.6	neutral	1.18	11.63	neutral	0.31	0.45	0.49	neutral	0.71	disease	0.62	disease	0.65	disease	3	0.68	neutral	0.42	neutral	-3	neutral	0.59	deleterious	-1.17	low_impact	0.26	medium_impact	-0.12	medium_impact	0.68	0.85	1.15	11.16	0.3	N	0.64	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4528	4528	C	T	MI.12876	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	59	20	T	M	aCa/aTa	4.63	0.98	0	probably_damaging	0.98	neutral	0.27	neutral	4.26	neutral	1.01	neutral	-1.62	medium_impact	2.82	0.91	neutral	0.51	neutral	3.64	23.20	deleterious	0.08	0.35	0.57	disease	0.77	disease	0.66	disease	0.69	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.71	deleterious	-2.34	low_impact	-0.03	medium_impact	1.23	medium_impact	0.71	0.85	1.15	11.16	0.57	P	0.82	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4528	4528	C	A	MI.12877	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	59	20	T	K	aCa/aAa	4.63	0.98	0	probably_damaging	0.91	neutral	0.26	neutral	4.07	neutral	-2.31	deleterious	-3.16	medium_impact	3.02	0.88	neutral	0.45	neutral	2.46	19.19	deleterious	0.05	0.35	0.63	disease	0.86	disease	0.77	disease	0.78	disease	6	0.93	neutral	0.18	neutral	1	deleterious	0.74	deleterious	-1.72	low_impact	-0.04	medium_impact	1.4	medium_impact	0.43	0.8	1.15	11.16	0.6	P	0.95	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4530	4530	G	T	MI.12878	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	61	21	A	S	Gcg/Tcg	-12.17	0	0	benign	0.02	neutral	0.72	neutral	4.07	neutral	-2.05	neutral	-0.22	low_impact	0.95	0.92	neutral	0.65	neutral	3.42	23.00	deleterious	0.19	0.45	0.39	neutral	0.38	neutral	0.46	neutral	0.47	neutral	1	0.24	neutral	0.85	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	0.44	medium_impact	-0.35	medium_impact	0.57	0.8	1.73	8.04	0.31	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4530	4530	G	A	MI.12879	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	61	21	A	T	Gcg/Acg	-12.17	0	0	benign	0.01	neutral	0.52	neutral	4.08	neutral	-1.77	neutral	0.1	neutral_impact	0.38	0.92	neutral	0.94	neutral	2.83	21.50	deleterious	0.15	0.45	0.27	neutral	0.31	neutral	0.45	neutral	0.45	neutral	1	0.47	neutral	0.76	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.23	medium_impact	-0.83	medium_impact	0.68	0.85	1.73	8.04	0.35	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9131	9131	T	A	MI.1288	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	605	202	L	Q	cTa/cAa	0.13	0	0	probably_damaging	1	deleterious	0	neutral	3.25	deleterious	-6.49	deleterious	-5.38	high_impact	4.47	0.36	damaging	0.48	neutral	4.18	23.80	deleterious	0.15	0.65	NA	NA	0.81	disease	0.66	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	2.73	high_impact	0.47	0.9	49.56	8.88	0.64	P	0.98	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4530	4530	G	C	MI.12880	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	61	21	A	P	Gcg/Ccg	-12.17	0	0	possibly_damaging	0.64	neutral	0.19	neutral	4.02	deleterious	-3.31	neutral	-1.39	medium_impact	2.04	0.83	neutral	0.37	neutral	3.65	23.20	deleterious	0.04	0.35	0.63	disease	0.82	disease	0.69	disease	0.8	disease	6	0.82	neutral	0.28	neutral	0	NA	0.60	deleterious	-1.03	low_impact	-0.14	medium_impact	0.57	medium_impact	0.60	0.8	1.73	8.04	0.25	N	0.70	polymorphism	1	0.03	rs28739288	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4531	4531	C	T	MI.12881	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	62	21	A	V	gCg/gTg	-1.58	0	0	benign	0.08	neutral	0.52	neutral	4.26	neutral	-0.11	neutral	1.35	neutral_impact	0.16	0.97	neutral	0.95	neutral	4.14	23.80	deleterious	0.15	0.4	0.21	neutral	0.44	neutral	0.37	neutral	0.45	neutral	1	0.41	neutral	0.72	deleterious	-6	neutral	0.14	neutral	0.17	medium_impact	0.23	medium_impact	-1.01	low_impact	0.68	0.85	1.73	8.04	0.31	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4531	4531	C	G	MI.12882	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	62	21	A	G	gCg/gGg	-1.58	0	0	benign	0.19	neutral	0.36	neutral	4.03	deleterious	-3.58	neutral	-2.15	low_impact	1.5	0.89	neutral	0.59	neutral	3.70	23.30	deleterious	0.12	0.4	0.55	disease	0.48	neutral	0.53	disease	0.63	disease	3	0.57	neutral	0.59	deleterious	-6	neutral	0.27	neutral	-0.22	medium_impact	0.07	medium_impact	0.12	medium_impact	0.57	0.8	1.73	8.04	0.37	N	0.50	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4531	4531	C	A	MI.12883	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	62	21	A	E	gCg/gAg	-1.58	0	0	benign	0.35	neutral	0.3	neutral	4.01	deleterious	-4	neutral	-1.35	medium_impact	2.04	0.92	neutral	0.59	neutral	4.35	24.10	deleterious	0.03	0.35	0.52	disease	0.74	disease	0.68	disease	0.75	disease	5	0.64	neutral	0.48	deleterious	-3	neutral	0.45	deleterious	-0.55	medium_impact	0	medium_impact	0.57	medium_impact	0.51	0.8	1.73	8.04	0.34	N	0.67	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4533	4533	C	A	MI.12884	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	64	22	L	M	Cta/Ata	-2.27	0	0	benign	0.32	neutral	0.24	neutral	4.08	neutral	-2.68	neutral	-0.14	neutral_impact	-0.82	0.96	neutral	0.81	neutral	0.58	8.00	deleterious	0.25	0.45	0.46	neutral	0.23	neutral	0.28	neutral	0.43	neutral	1	0.71	neutral	0.46	neutral	-6	neutral	0.35	neutral	-0.5	medium_impact	-0.07	medium_impact	-1.84	low_impact	0.55	0.8	4.03	7.25	0.5	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4533	4533	C	G	MI.12885	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	64	22	L	V	Cta/Gta	-2.27	0	0	possibly_damaging	0.56	neutral	0.53	neutral	4.15	neutral	-1.3	neutral	-0.23	neutral_impact	0.3	0.92	neutral	0.89	neutral	-1.41	0.00	neutral	0.24	0.45	0.47	neutral	0.41	neutral	0.37	neutral	0.44	neutral	1	0.53	neutral	0.49	deleterious	-3	neutral	0.46	deleterious	-0.89	medium_impact	0.24	medium_impact	-0.89	medium_impact	0.54	0.8	4.03	7.25	0.34	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4534	4534	T	C	MI.12886	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	65	22	L	P	cTa/cCa	-2.5	0	0	probably_damaging	0.9	neutral	0.21	neutral	4.04	deleterious	-4.22	deleterious	-3.28	low_impact	0.85	0.69	neutral	0.41	neutral	0.71	8.92	deleterious	0.03	0.35	0.83	disease	0.85	disease	0.64	disease	0.82	disease	6	0.94	neutral	0.16	neutral	-2	neutral	0.80	deleterious	-1.67	low_impact	-0.11	medium_impact	-0.43	medium_impact	0.24	0.8	4.03	7.25	0.28	N	0.90	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4534	4534	T	G	MI.12887	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	65	22	L	R	cTa/cGa	-2.5	0	0	possibly_damaging	0.87	neutral	0.35	neutral	4.06	deleterious	-3.41	deleterious	-2.87	low_impact	1.2	0.81	neutral	0.48	neutral	2.03	16.41	deleterious	0.03	0.35	0.77	disease	0.85	disease	0.71	disease	0.8	disease	6	0.88	neutral	0.24	neutral	-3	neutral	0.78	deleterious	-1.55	low_impact	0.06	medium_impact	-0.13	medium_impact	0.19	0.8	4.03	7.25	0.28	N	0.79	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4534	4534	T	A	MI.12888	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	65	22	L	Q	cTa/cAa	-2.5	0	0	probably_damaging	0.9	neutral	0.3	neutral	4.06	deleterious	-3.01	deleterious	-2.74	low_impact	1.2	0.85	neutral	0.56	neutral	0.99	10.58	neutral	0.04	0.35	0.79	disease	0.6	disease	0.5	neutral	0.56	disease	1	0.92	neutral	0.2	neutral	-2	neutral	0.71	deleterious	-1.67	low_impact	0	medium_impact	-0.13	medium_impact	0.26	0.8	4.03	7.25	0.31	N	0.81	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4536	4536	A	T	MI.12889	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	67	23	S	C	Agc/Tgc	-6.19	0	0	probably_damaging	1	neutral	0.05	neutral	3.85	deleterious	-4.57	deleterious	-4.41	medium_impact	3.1	0.89	neutral	0.11	damaging	3.19	22.70	deleterious	0.04	0.35	0.8	disease	0.86	disease	0.68	disease	0.73	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.5	medium_impact	1.47	medium_impact	0.30	0.8	NA	NA	0.4	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9131	9131	T	G	MI.1289	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	605	202	L	R	cTa/cGa	0.13	0	0	probably_damaging	1	deleterious	0	neutral	3.25	deleterious	-6.16	deleterious	-5.38	high_impact	4.47	0.45	damaging	0.43	neutral	4.27	24.00	deleterious	0.14	0.65	NA	NA	0.91	disease	0.76	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.6	low_impact	-1.4	low_impact	2.73	high_impact	0.32	0.9	49.56	8.88	0.55	N	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4536	4536	A	C	MI.12890	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	67	23	S	R	Agc/Cgc	-6.19	0	0	probably_damaging	1	neutral	0.1	neutral	3.82	deleterious	-6.18	deleterious	-4.44	high_impact	3.91	0.87	neutral	0.09	damaging	3.62	23.20	deleterious	0.04	0.35	0.74	disease	0.9	disease	0.82	disease	0.8	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.32	medium_impact	2.15	high_impact	0.32	0.8	NA	NA	0.47	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4536	4536	A	G	MI.12891	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	67	23	S	G	Agc/Ggc	-6.19	0	0	probably_damaging	1	neutral	0.09	neutral	3.84	deleterious	-5.04	deleterious	-3.54	medium_impact	3.36	0.94	neutral	0.28	neutral	3.31	22.90	deleterious	0.08	0.35	0.7	disease	0.69	disease	0.7	disease	0.67	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.35	medium_impact	1.68	medium_impact	0.35	0.8	NA	NA	0.46	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4537	4537	G	A	MI.12892	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	68	23	S	N	aGc/aAc	6.71	1	0	probably_damaging	1	neutral	0.16	neutral	3.82	deleterious	-5.85	deleterious	-2.72	medium_impact	3.36	0.9	neutral	0.13	damaging	3.40	23.00	deleterious	0.17	0.45	0.76	disease	0.83	disease	0.74	disease	0.74	disease	5	1	deleterious	0.08	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.19	medium_impact	1.68	medium_impact	0.27	0.8	NA	NA	0.65	P	0.89	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4537	4537	G	C	MI.12893	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	68	23	S	T	aGc/aCc	6.71	1	0	probably_damaging	1	neutral	0.14	neutral	3.85	deleterious	-4.62	deleterious	-2.62	medium_impact	2.39	0.96	neutral	0.54	neutral	3.15	22.60	deleterious	0.11	0.4	0.49	neutral	0.67	disease	0.69	disease	0.59	disease	2	1	deleterious	0.07	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.23	medium_impact	0.87	medium_impact	0.50	0.8	NA	NA	0.65	P	0.71	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4537	4537	G	T	MI.12894	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	68	23	S	I	aGc/aTc	6.71	1	0	probably_damaging	1	neutral	0.15	neutral	3.82	deleterious	-5.83	deleterious	-5.32	high_impact	3.56	0.91	neutral	0.12	damaging	3.87	23.50	deleterious	0.04	0.35	0.35	neutral	0.92	disease	0.75	disease	0.75	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	-0.21	medium_impact	1.85	medium_impact	0.31	0.8	NA	NA	0.6	P	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4539	4539	T	G	MI.12895	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	70	24	S	A	Tcg/Gcg	-0.2	0.01	0	probably_damaging	1	neutral	0.51	neutral	4.52	neutral	0.13	deleterious	-2.72	medium_impact	2.44	0.91	neutral	0.62	neutral	3.48	23.10	deleterious	0.22	0.45	0.42	neutral	0.63	disease	0.65	disease	0.69	disease	4	0.99	deleterious	0.26	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.22	medium_impact	0.91	medium_impact	0.35	0.8	NA	NA	0.35	N	0.41	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4539	4539	T	C	MI.12896	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	70	24	S	P	Tcg/Ccg	-0.2	0.01	0	probably_damaging	1	neutral	0.2	neutral	4.48	neutral	-2.34	deleterious	-4.47	low_impact	1.78	0.9	neutral	0.43	neutral	3.75	23.30	deleterious	0.05	0.35	0.22	neutral	0.91	disease	0.75	disease	0.71	disease	4	1	deleterious	0.1	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	-0.13	medium_impact	0.35	medium_impact	0.20	0.8	NA	NA	0.41	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4539	4539	T	A	MI.12897	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	70	24	S	T	Tcg/Acg	-0.2	0.01	0	probably_damaging	1	neutral	0.4	neutral	4.52	neutral	-0.3	deleterious	-2.58	low_impact	1.31	0.88	neutral	0.89	neutral	2.49	19.38	deleterious	0.19	0.45	0.38	neutral	0.51	disease	0.45	neutral	0.35	neutral	3	1	deleterious	0.2	neutral	-2	neutral	0.70	deleterious	-3.54	low_impact	0.11	medium_impact	-0.04	medium_impact	0.45	0.8	NA	NA	0.37	N	0.23	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4540	4540	C	T	MI.12898	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	71	24	S	L	tCg/tTg	0.49	0	0	probably_damaging	1	neutral	0.69	neutral	4.53	neutral	-0.9	deleterious	-5.37	medium_impact	2.86	0.9	neutral	0.48	neutral	4.46	24.20	deleterious	0.09	0.4	0.55	disease	0.86	disease	0.62	disease	0.72	disease	4	1	deleterious	0.35	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.4	medium_impact	1.26	medium_impact	0.52	0.8	NA	NA	0.32	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4540	4540	C	G	MI.12899	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	71	24	S	W	tCg/tGg	0.49	0	0	probably_damaging	1	neutral	0.24	neutral	4.45	deleterious	-4.25	deleterious	-6.29	medium_impact	3.41	0.88	neutral	0.44	neutral	4.17	23.80	deleterious	0.06	0.35	0.9	disease	0.92	disease	0.69	disease	0.72	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.07	medium_impact	1.73	medium_impact	0.14	0.8	NA	NA	0.39	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8587	8587	G	T	MI.129	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	61	21	V	L	Gta/Tta	-8.2	0	0	benign	0.19	neutral	0.58	neutral	4.6	neutral	1.18	neutral	-0.64	neutral_impact	-1.18	0.91	neutral	0.96	neutral	-0.54	0.18	neutral	0.48	0.65	0.32	neutral	0.16	neutral	0.21	neutral	0.27	neutral	5	0.31	neutral	0.7	deleterious	-6	neutral	0.19	neutral	-0.16	medium_impact	0.37	medium_impact	-2.11	low_impact	0.64	0.9	22.57	20.88	0.36	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9133	9133	G	C	MI.1290	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	607	203	E	Q	Gaa/Caa	-4.04	0	0	probably_damaging	0.99	deleterious	0	neutral	3.42	deleterious	-4.06	deleterious	-2.66	high_impact	4.23	0.49	damaging	0.55	neutral	3.41	23.00	deleterious	0.38	0.65	NA	NA	0.77	disease	0.73	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-1.4	low_impact	2.53	high_impact	0.64	0.9	48.67	8.97	0.49	N	0.91	disease_causing	0.98	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4542	4542	C	T	MI.12900	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	73	25	H	Y	Cac/Tac	-3.42	0	0	probably_damaging	1	neutral	1	neutral	4.58	neutral	-2.79	deleterious	-5.4	medium_impact	3.17	0.86	neutral	0.09	damaging	3.55	23.10	deleterious	0.1	0.4	0.55	disease	0.87	disease	0.78	disease	0.73	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.82	deleterious	-3.54	low_impact	1.87	high_impact	1.52	medium_impact	0.31	0.8	0.58	7.17	0.29	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4542	4542	C	G	MI.12901	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	73	25	H	D	Cac/Gac	-3.42	0	0	probably_damaging	1	neutral	0.2	neutral	4.97	neutral	2.68	deleterious	-7.95	medium_impact	3.03	0.88	neutral	0.1	damaging	3.66	23.20	deleterious	0.05	0.35	0.48	neutral	0.83	disease	0.82	disease	0.75	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.13	medium_impact	1.41	medium_impact	0.37	0.8	0.58	7.17	0.43	N	0.91	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4542	4542	C	A	MI.12902	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	73	25	H	N	Cac/Aac	-3.42	0	0	probably_damaging	1	neutral	0.49	neutral	5.02	neutral	2.89	deleterious	-6.01	low_impact	1.64	0.89	neutral	0.7	neutral	2.60	20.20	deleterious	0.22	0.45	0.23	neutral	0.81	disease	0.75	disease	0.44	neutral	1	1	deleterious	0.25	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	0.2	medium_impact	0.24	medium_impact	0.38	0.8	0.58	7.17	0.36	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4543	4543	A	T	MI.12903	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	74	25	H	L	cAc/cTc	2.1	0.95	0	probably_damaging	1	neutral	0.71	neutral	4.59	neutral	-1.83	deleterious	-9.85	medium_impact	3.38	0.84	neutral	0.09	damaging	3.62	23.20	deleterious	0.04	0.35	0.23	neutral	0.89	disease	0.78	disease	0.7	disease	4	1	deleterious	0.36	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.42	medium_impact	1.7	medium_impact	0.20	0.8	0.58	7.17	0.46	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4543	4543	A	C	MI.12904	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	74	25	H	P	cAc/cCc	2.1	0.95	0	probably_damaging	1	neutral	0.25	neutral	4.59	neutral	-1.99	deleterious	-8.93	high_impact	3.73	0.84	neutral	0.1	damaging	3.04	22.40	deleterious	0.03	0.35	0.63	disease	0.87	disease	0.84	disease	0.76	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.06	medium_impact	2	medium_impact	0.19	0.8	0.58	7.17	0.56	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4543	4543	A	G	MI.12905	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	74	25	H	R	cAc/cGc	2.1	0.95	0	probably_damaging	1	neutral	0.36	neutral	4.61	neutral	-0.99	deleterious	-7.1	high_impact	3.73	0.86	neutral	0.1	damaging	2.77	21.20	deleterious	0.08	0.35	0.45	neutral	0.85	disease	0.81	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.07	medium_impact	2	medium_impact	0.41	0.8	0.58	7.17	0.49	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4544	4544	C	G	MI.12906	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	75	25	H	Q	caC/caG	4.63	0.99	0	probably_damaging	1	neutral	0.29	neutral	4.62	neutral	-0.51	deleterious	-7.1	medium_impact	3.03	0.9	neutral	0.11	damaging	3.36	22.90	deleterious	0.11	0.4	0.43	neutral	0.8	disease	0.78	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.01	medium_impact	1.41	medium_impact	0.29	0.8	0.58	7.17	0.57	P	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4544	4544	C	A	MI.12907	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	75	25	H	Q	caC/caA	4.63	0.99	0	probably_damaging	1	neutral	0.29	neutral	4.62	neutral	-0.51	deleterious	-7.1	medium_impact	3.03	0.9	neutral	0.11	damaging	3.63	23.20	deleterious	0.11	0.4	0.43	neutral	0.8	disease	0.78	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.01	medium_impact	1.41	medium_impact	0.29	0.8	0.58	7.17	0.58	P	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4545	4545	T	C	MI.12908	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	76	26	W	R	Tga/Cga	0.03	0.96	0	probably_damaging	1	neutral	0.23	neutral	4.54	neutral	-2.58	deleterious	-12.83	high_impact	3.96	0.78	neutral	0.11	damaging	3.38	23.00	deleterious	0.03	0.35	0.65	disease	0.9	disease	0.84	disease	0.77	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.08	medium_impact	2.19	high_impact	0.13	0.8	2.59	8.07	0.52	P	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4545	4545	T	G	MI.12909	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	76	26	W	G	Tga/Gga	0.03	0.96	0	probably_damaging	1	neutral	0.26	neutral	4.54	neutral	-2.63	deleterious	-11.91	high_impact	3.96	0.9	neutral	0.12	damaging	3.65	23.20	deleterious	0.04	0.35	0.66	disease	0.84	disease	0.81	disease	0.74	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.04	medium_impact	2.19	high_impact	0.08	0.8	2.59	8.07	0.58	P	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9133	9133	G	A	MI.1291	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	607	203	E	K	Gaa/Aaa	-4.04	0	0	probably_damaging	0.99	deleterious	0	neutral	3.44	deleterious	-3.55	deleterious	-3.55	high_impact	3.6	0.52	damaging	0.44	neutral	4.56	24.40	deleterious	0.28	0.65	NA	NA	0.9	disease	0.78	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.92	deleterious	-2.65	low_impact	-1.4	low_impact	1.99	medium_impact	0.66	0.9	48.67	8.97	0.43	N	1.00	disease_causing	1	0.30	.	.	.	.	.	.	COSM1138419	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4546	4546	G	T	MI.12910	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	77	26	W	L	tGa/tTa	2.33	1	0	probably_damaging	1	neutral	0.58	neutral	5.18	neutral	2.72	deleterious	-11.91	medium_impact	2.34	0.94	neutral	0.62	neutral	2.96	22.10	deleterious	0.08	0.35	0.22	neutral	0.83	disease	0.76	disease	0.58	disease	2	1	deleterious	0.29	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.29	medium_impact	0.83	medium_impact	0.08	0.8	2.59	8.07	0.47	N	0.65	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4546	4546	G	C	MI.12911	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	77	26	W	S	tGa/tCa	2.33	1	0	probably_damaging	1	neutral	0.64	neutral	4.56	neutral	-1.62	deleterious	-12.83	medium_impact	3.42	0.78	neutral	0.12	damaging	3.87	23.50	deleterious	0.04	0.35	0.47	neutral	0.89	disease	0.79	disease	0.74	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.35	medium_impact	1.73	medium_impact	0.06	0.8	2.59	8.07	0.47	N	0.95	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4547	4547	A	C	MI.12912	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	78	26	W	C	tgA/tgC	5.78	1	0	probably_damaging	1	neutral	0.11	neutral	4.56	neutral	-1.81	deleterious	-11.91	high_impact	3.96	0.75	neutral	0.1	damaging	3.84	23.40	deleterious	0.04	0.35	0.61	disease	0.89	disease	0.82	disease	0.76	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.3	medium_impact	2.19	high_impact	0.15	0.8	2.59	8.07	0.66	P	0.89	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4547	4547	A	T	MI.12913	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	78	26	W	C	tgA/tgT	5.78	1	0	probably_damaging	1	neutral	0.11	neutral	4.56	neutral	-1.81	deleterious	-11.91	high_impact	3.96	0.75	neutral	0.1	damaging	3.92	23.50	deleterious	0.04	0.35	0.61	disease	0.89	disease	0.82	disease	0.76	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.3	medium_impact	2.19	high_impact	0.15	0.8	2.59	8.07	0.66	P	0.89	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4548	4548	T	G	MI.12914	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	79	27	F	V	Ttt/Gtt	1.64	0.79	0	possibly_damaging	0.56	neutral	0.38	neutral	4.58	neutral	-0.6	neutral	-0.95	low_impact	1.26	0.86	neutral	0.69	neutral	2.17	17.32	deleterious	0.07	0.35	0.25	neutral	0.52	disease	0.54	disease	0.4	neutral	2	0.63	neutral	0.41	neutral	-3	neutral	0.55	deleterious	-0.89	medium_impact	0.09	medium_impact	-0.08	medium_impact	0.32	0.8	0.29	7.84	0.34	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4548	4548	T	A	MI.12915	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	79	27	F	I	Ttt/Att	1.64	0.79	0	benign	0.43	neutral	0.36	neutral	4.82	neutral	1.07	neutral	-0.04	low_impact	1	0.87	neutral	0.77	neutral	1.34	12.46	neutral	0.15	0.4	0.2	neutral	0.5	disease	0.37	neutral	0.24	neutral	5	0.59	neutral	0.47	neutral	-6	neutral	0.52	deleterious	-0.69	medium_impact	0.07	medium_impact	-0.3	medium_impact	0.49	0.8	0.29	7.84	0.35	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4548	4548	T	C	MI.12916	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	79	27	F	L	Ttt/Ctt	1.64	0.79	0	benign	0.04	neutral	1	neutral	4.89	neutral	1.33	neutral	1.32	neutral_impact	-0.38	0.92	neutral	0.98	neutral	-0.70	0.07	neutral	0.14	0.4	0.34	neutral	0.21	neutral	0.26	neutral	0.36	neutral	3	0.04	neutral	0.98	deleterious	-6	neutral	0.14	neutral	0.47	medium_impact	1.87	high_impact	-1.46	low_impact	0.71	0.85	0.29	7.84	0.3	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4549	4549	T	A	MI.12917	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	80	27	F	Y	tTt/tAt	-4.35	0	0	possibly_damaging	0.77	neutral	0.62	neutral	4.48	neutral	-2.9	neutral	-1.38	medium_impact	2.34	0.9	neutral	0.52	neutral	2.72	20.90	deleterious	0.11	0.4	0.5	disease	0.62	disease	0.58	disease	0.69	disease	4	0.73	neutral	0.43	neutral	0	NA	0.68	deleterious	-1.28	low_impact	0.33	medium_impact	0.83	medium_impact	0.62	0.8	0.29	7.84	0.34	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4549	4549	T	G	MI.12918	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	80	27	F	C	tTt/tGt	-4.35	0	0	probably_damaging	0.97	neutral	0.1	neutral	4.47	deleterious	-3.69	deleterious	-2.55	medium_impact	3.03	0.86	neutral	0.4	neutral	3.91	23.50	deleterious	0.02	0.35	0.63	disease	0.81	disease	0.61	disease	0.74	disease	5	0.99	deleterious	0.07	neutral	1	deleterious	0.74	deleterious	-2.18	low_impact	-0.32	medium_impact	1.41	medium_impact	0.23	0.8	0.29	7.84	0.34	N	0.71	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4549	4549	T	C	MI.12919	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	80	27	F	S	tTt/tCt	-4.35	0	0	probably_damaging	0.9	neutral	0.45	neutral	4.49	neutral	-2.42	deleterious	-3.23	medium_impact	2.34	0.84	neutral	0.53	neutral	3.86	23.50	deleterious	0.02	0.35	0.38	neutral	0.66	disease	0.62	disease	0.7	disease	4	0.9	neutral	0.28	neutral	1	deleterious	0.69	deleterious	-1.67	low_impact	0.16	medium_impact	0.83	medium_impact	0.37	0.8	0.29	7.84	0.26	N	0.78	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9134	9134	A	C	MI.1292	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	608	203	E	A	gAa/gCa	9.38	1	0	probably_damaging	0.99	deleterious	0	neutral	3.43	deleterious	-4.06	deleterious	-5.3	high_impact	4.58	0.56	damaging	0.55	neutral	3.62	23.20	deleterious	0.21	0.65	NA	NA	0.72	disease	0.72	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-1.4	low_impact	2.83	high_impact	0.46	0.9	48.67	8.97	0.53	P	0.80	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4550	4550	T	G	MI.12920	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	81	27	F	L	ttT/ttG	4.4	0.64	0	benign	0.04	neutral	1	neutral	4.89	neutral	1.33	neutral	1.32	neutral_impact	-0.38	0.92	neutral	0.98	neutral	-0.64	0.10	neutral	0.14	0.4	0.34	neutral	0.21	neutral	0.26	neutral	0.36	neutral	3	0.04	neutral	0.98	deleterious	-6	neutral	0.14	neutral	0.47	medium_impact	1.87	high_impact	-1.46	low_impact	0.71	0.85	0.29	7.84	0.36	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4550	4550	T	A	MI.12921	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	81	27	F	L	ttT/ttA	4.4	0.64	0	benign	0.04	neutral	1	neutral	4.89	neutral	1.33	neutral	1.32	neutral_impact	-0.38	0.92	neutral	0.98	neutral	-0.45	0.30	neutral	0.14	0.4	0.34	neutral	0.21	neutral	0.26	neutral	0.36	neutral	3	0.04	neutral	0.98	deleterious	-6	neutral	0.14	neutral	0.47	medium_impact	1.87	high_impact	-1.46	low_impact	0.71	0.85	0.29	7.84	0.37	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4551	4551	T	A	MI.12922	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	82	28	F	I	Ttt/Att	-12.86	0	0	benign	0	neutral	0.29	neutral	4.74	neutral	0.42	neutral	1.13	neutral_impact	-0.12	0.91	neutral	0.64	neutral	2.16	17.23	deleterious	0.14	0.4	0.48	neutral	0.64	disease	0.44	neutral	0.35	neutral	3	0.71	neutral	0.65	deleterious	-6	neutral	0.20	neutral	1.95	medium_impact	-0.01	medium_impact	-1.25	low_impact	0.52	0.8	NA	NA	0.37	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4551	4551	T	G	MI.12923	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	82	28	F	V	Ttt/Gtt	-12.86	0	0	benign	0.01	neutral	0.45	neutral	4.73	neutral	0.94	neutral	0.76	neutral_impact	0.33	0.93	neutral	0.9	neutral	0.77	9.28	deleterious	0.12	0.4	0.46	neutral	0.63	disease	0.46	neutral	0.42	neutral	2	0.53	neutral	0.72	deleterious	-6	neutral	0.19	neutral	1.03	medium_impact	0.16	medium_impact	-0.87	medium_impact	0.43	0.8	NA	NA	0.3	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4551	4551	T	C	MI.12924	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	82	28	F	L	Ttt/Ctt	-12.86	0	0	benign	0	neutral	1	neutral	4.91	neutral	1.47	neutral	2.27	neutral_impact	-1.26	0.97	neutral	0.97	neutral	-0.93	0.02	neutral	0.16	0.45	0.26	neutral	0.19	neutral	0.28	neutral	0.32	neutral	4	0	neutral	1	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	1.87	high_impact	-2.21	low_impact	0.70	0.85	NA	NA	0.33	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4552	4552	T	C	MI.12925	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	83	28	F	S	tTt/tCt	-7.11	0	0	benign	0.2	neutral	0.36	neutral	4.78	neutral	-0.02	neutral	-1.27	neutral_impact	-0.32	0.87	neutral	0.62	neutral	2.27	17.94	deleterious	0.06	0.35	0.59	disease	0.57	disease	0.55	disease	0.61	disease	2	0.57	neutral	0.58	deleterious	-6	neutral	0.42	neutral	-0.25	medium_impact	0.07	medium_impact	-1.41	low_impact	0.48	0.8	NA	NA	0.29	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4552	4552	T	A	MI.12926	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	83	28	F	Y	tTt/tAt	-7.11	0	0	benign	0.2	neutral	0.29	neutral	4.63	neutral	-0.96	neutral	-0.86	low_impact	1.02	0.91	neutral	0.58	neutral	2.24	17.76	deleterious	0.18	0.45	0.7	disease	0.54	disease	0.52	disease	0.56	disease	1	0.65	neutral	0.55	deleterious	-6	neutral	0.44	deleterious	-0.25	medium_impact	-0.01	medium_impact	-0.29	medium_impact	0.71	0.85	NA	NA	0.4	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4552	4552	T	G	MI.12927	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	83	28	F	C	tTt/tGt	-7.11	0	0	possibly_damaging	0.69	neutral	0.17	neutral	4.62	neutral	-2.35	neutral	-0.99	low_impact	0.91	0.83	neutral	0.44	neutral	3.70	23.30	deleterious	0.06	0.35	0.8	disease	0.77	disease	0.54	disease	0.71	disease	4	0.86	neutral	0.24	neutral	-3	neutral	0.71	deleterious	-1.12	low_impact	-0.17	medium_impact	-0.38	medium_impact	0.23	0.8	NA	NA	0.31	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4553	4553	T	G	MI.12928	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	84	28	F	L	ttT/ttG	0.72	0	0.01	benign	0	neutral	1	neutral	4.91	neutral	1.47	neutral	2.27	neutral_impact	-1.26	0.97	neutral	0.97	neutral	-0.59	0.13	neutral	0.16	0.45	0.26	neutral	0.19	neutral	0.28	neutral	0.32	neutral	4	0	neutral	1	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	1.87	high_impact	-2.21	low_impact	0.70	0.85	NA	NA	0.32	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4553	4553	T	A	MI.12929	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	84	28	F	L	ttT/ttA	0.72	0	0.01	benign	0	neutral	1	neutral	4.91	neutral	1.47	neutral	2.27	neutral_impact	-1.26	0.97	neutral	0.97	neutral	-0.46	0.28	neutral	0.16	0.45	0.26	neutral	0.19	neutral	0.28	neutral	0.32	neutral	4	0	neutral	1	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	1.87	high_impact	-2.21	low_impact	0.70	0.85	NA	NA	0.32	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9134	9134	A	G	MI.1293	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	608	203	E	G	gAa/gGa	9.38	1	0	probably_damaging	0.99	deleterious	0	neutral	3.49	deleterious	-4.01	deleterious	-6.22	high_impact	4.03	0.53	damaging	0.62	neutral	4.14	23.80	deleterious	0.3	0.65	NA	NA	0.83	disease	0.73	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-1.4	low_impact	2.36	high_impact	0.40	0.9	48.67	8.97	0.5	N	0.71	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	A9134G	Hypotonia, lactic acidosis, HCM, IUGR	nr	nr	Reported	1	.	.	.	damaging
chrM	4554	4554	A	G	MI.12930	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	85	29	T	A	Acc/Gcc	-2.96	0	0	benign	0	neutral	0.61	neutral	4.73	neutral	1.41	neutral	-0.08	neutral_impact	-1.21	0.95	neutral	0.94	neutral	-1.39	0.00	neutral	0.18	0.45	0.21	neutral	0.1	neutral	0.28	neutral	0.23	neutral	6	0.39	neutral	0.81	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.32	medium_impact	-2.16	low_impact	0.39	0.8	4.61	10.18	0.42	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4554	4554	A	C	MI.12931	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	85	29	T	P	Acc/Ccc	-2.96	0	0	benign	0.24	neutral	0.2	neutral	4.61	neutral	-1.9	neutral	-2.14	medium_impact	2.08	0.76	neutral	0.37	neutral	0.31	5.75	deleterious	0.05	0.35	0.64	disease	0.87	disease	0.66	disease	0.79	disease	6	0.76	neutral	0.48	deleterious	-3	neutral	0.37	neutral	-0.34	medium_impact	-0.13	medium_impact	0.61	medium_impact	0.35	0.8	4.61	10.18	0.27	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4554	4554	A	T	MI.12932	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	85	29	T	S	Acc/Tcc	-2.96	0	0	benign	0.06	neutral	0.42	neutral	4.63	neutral	-0.38	neutral	-1.05	neutral_impact	0.32	0.9	neutral	0.84	neutral	0.06	3.20	deleterious	0.33	0.5	0.42	neutral	0.51	disease	0.49	neutral	0.5	neutral	0	0.54	neutral	0.68	deleterious	-6	neutral	0.18	neutral	0.3	medium_impact	0.13	medium_impact	-0.88	medium_impact	0.59	0.8	4.61	10.18	0.34	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4555	4555	C	T	MI.12933	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	86	29	T	I	aCc/aTc	1.18	0	0	benign	0	neutral	0.42	neutral	4.85	neutral	2.42	neutral	1.8	neutral_impact	0.27	0.92	neutral	0.98	neutral	-0.56	0.15	neutral	0.09	0.35	0.24	neutral	0.67	disease	0.34	neutral	0.22	neutral	6	0.58	neutral	0.71	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.13	medium_impact	-0.92	medium_impact	0.67	0.85	4.61	10.18	0.3	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4555	4555	C	A	MI.12934	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	86	29	T	N	aCc/aAc	1.18	0	0	benign	0.24	neutral	0.31	neutral	4.61	neutral	-1.6	neutral	-2.26	medium_impact	2.08	0.85	neutral	0.56	neutral	1.56	13.65	neutral	0.23	0.45	0.6	disease	0.78	disease	0.53	disease	0.7	disease	4	0.63	neutral	0.54	deleterious	-3	neutral	0.34	neutral	-0.34	medium_impact	0.02	medium_impact	0.61	medium_impact	0.65	0.8	4.61	10.18	0.29	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4555	4555	C	G	MI.12935	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	86	29	T	S	aCc/aGc	1.18	0	0	benign	0.06	neutral	0.42	neutral	4.63	neutral	-0.38	neutral	-1.05	neutral_impact	0.32	0.9	neutral	0.84	neutral	0.29	5.57	deleterious	0.33	0.5	0.42	neutral	0.51	disease	0.49	neutral	0.5	neutral	0	0.54	neutral	0.68	deleterious	-6	neutral	0.18	neutral	0.3	medium_impact	0.13	medium_impact	-0.88	medium_impact	0.59	0.8	4.61	10.18	0.36	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4557	4557	T	G	MI.12936	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	88	30	W	G	Tga/Gga	-2.96	0	0	probably_damaging	1	neutral	0.28	neutral	4.49	deleterious	-5.47	deleterious	-11.92	high_impact	4	0.58	damaging	0.06	damaging	3.77	23.40	deleterious	0.03	0.35	0.52	disease	0.86	disease	0.8	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	-0.02	medium_impact	2.22	high_impact	0.11	0.8	NA	NA	0.45	N	0.96	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4557	4557	T	C	MI.12937	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	88	30	W	R	Tga/Cga	-2.96	0	0	probably_damaging	1	neutral	0.17	neutral	4.49	deleterious	-5.33	deleterious	-12.83	high_impact	4	0.6	neutral	0.06	damaging	3.39	23.00	deleterious	0.02	0.35	0.37	neutral	0.92	disease	0.83	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.17	medium_impact	2.22	high_impact	0.14	0.8	NA	NA	0.45	N	0.97	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4558	4558	G	C	MI.12938	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	89	30	W	S	tGa/tCa	7.4	1	0	probably_damaging	1	neutral	0.32	neutral	4.5	deleterious	-4.16	deleterious	-12.83	high_impact	4	0.51	damaging	0.06	damaging	3.87	23.50	deleterious	0.02	0.35	0.41	neutral	0.91	disease	0.78	disease	0.73	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.03	medium_impact	2.22	high_impact	0.11	0.8	NA	NA	0.61	P	0.94	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4558	4558	G	T	MI.12939	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	89	30	W	L	tGa/tTa	7.4	1	0	probably_damaging	1	neutral	0.63	neutral	4.64	neutral	-1.9	deleterious	-11.92	high_impact	3.65	0.59	damaging	0.05	damaging	4.14	23.80	deleterious	0.03	0.35	0.44	neutral	0.87	disease	0.77	disease	0.72	disease	4	1	deleterious	0.32	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.34	medium_impact	1.93	medium_impact	0.12	0.8	NA	NA	0.6	P	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9134	9134	A	T	MI.1294	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	608	203	E	V	gAa/gTa	9.38	1	0	probably_damaging	1	deleterious	0	neutral	3.38	deleterious	-5.4	deleterious	-6.22	high_impact	4.58	0.47	damaging	0.48	neutral	4.10	23.70	deleterious	0.2	0.65	NA	NA	0.9	disease	0.78	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.83	high_impact	0.48	0.9	48.67	8.97	0.59	P	0.86	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4559	4559	A	T	MI.12940	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	90	30	W	C	tgA/tgT	9.01	1	0	probably_damaging	1	neutral	0.1	neutral	4.51	deleterious	-4.91	deleterious	-11.92	high_impact	4	0.61	neutral	0.05	damaging	3.97	23.60	deleterious	0.03	0.35	0.27	neutral	0.91	disease	0.8	disease	0.7	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	-0.32	medium_impact	2.22	high_impact	0.16	0.8	NA	NA	0.58	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4559	4559	A	C	MI.12941	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	90	30	W	C	tgA/tgC	9.01	1	0	probably_damaging	1	neutral	0.1	neutral	4.51	deleterious	-4.91	deleterious	-11.92	high_impact	4	0.61	neutral	0.05	damaging	3.84	23.40	deleterious	0.03	0.35	0.27	neutral	0.91	disease	0.8	disease	0.7	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	-0.32	medium_impact	2.22	high_impact	0.16	0.8	NA	NA	0.57	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4560	4560	G	A	MI.12942	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	91	31	V	M	Gta/Ata	2.1	0.94	0	benign	0.02	neutral	1	neutral	4.59	neutral	-0.48	neutral	-0.84	neutral_impact	-0.42	0.89	neutral	0.94	neutral	-0.68	0.08	neutral	0.17	0.45	0.32	neutral	0.13	neutral	0.21	neutral	0.24	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	1.87	high_impact	-1.5	low_impact	0.89	0.9	3.46	8.29	0.35	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4560	4560	G	T	MI.12943	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	91	31	V	L	Gta/Tta	2.1	0.94	0	benign	0	neutral	0.79	neutral	4.83	neutral	1.08	neutral	-0.78	neutral_impact	-0.04	0.93	neutral	0.9	neutral	0.41	6.70	deleterious	0.13	0.4	0.23	neutral	0.53	disease	0.31	neutral	0.22	neutral	6	0.2	neutral	0.9	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.53	medium_impact	-1.18	low_impact	0.58	0.8	3.46	8.29	0.3	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4560	4560	G	C	MI.12944	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	91	31	V	L	Gta/Cta	2.1	0.94	0	benign	0	neutral	0.79	neutral	4.83	neutral	1.08	neutral	-0.78	neutral_impact	-0.04	0.93	neutral	0.9	neutral	0.26	5.32	deleterious	0.13	0.4	0.23	neutral	0.53	disease	0.31	neutral	0.22	neutral	6	0.2	neutral	0.9	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.53	medium_impact	-1.18	low_impact	0.58	0.8	3.46	8.29	0.3	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4561	4561	T	G	MI.12945	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	92	31	V	G	gTa/gGa	0.03	0	0.01	benign	0.14	neutral	0.52	neutral	4.48	deleterious	-3.29	deleterious	-4.96	medium_impact	2.21	0.87	neutral	0.53	neutral	3.32	22.90	deleterious	0.02	0.35	0.64	disease	0.63	disease	0.59	disease	0.71	disease	4	0.39	neutral	0.69	deleterious	-3	neutral	0.35	neutral	-0.08	medium_impact	0.23	medium_impact	0.72	medium_impact	0.27	0.8	3.46	8.29	0.31	N	0.76	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4561	4561	T	C	MI.12946	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	92	31	V	A	gTa/gCa	0.03	0	0.01	benign	0	neutral	0.52	neutral	4.52	neutral	-1.54	neutral	-2.24	neutral_impact	0.38	0.95	neutral	0.95	neutral	0.22	4.94	deleterious	0.08	0.35	0.38	neutral	0.3	neutral	0.39	neutral	0.44	neutral	1	0.47	neutral	0.76	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.23	medium_impact	-0.83	medium_impact	0.33	0.8	3.46	8.29	0.3	N	0.40	polymorphism	1	0.05	rs41376350	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4561	4561	T	A	MI.12947	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	92	31	V	E	gTa/gAa	0.03	0	0.01	benign	0.34	neutral	0.34	neutral	4.47	deleterious	-3.54	deleterious	-4.3	medium_impact	2.56	0.9	neutral	0.51	neutral	4.58	24.40	deleterious	0.02	0.35	0.57	disease	0.82	disease	0.69	disease	0.77	disease	5	0.59	neutral	0.5	deleterious	-3	neutral	0.56	deleterious	-0.53	medium_impact	0.05	medium_impact	1.01	medium_impact	0.26	0.8	3.46	8.29	0.37	N	0.82	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4563	4563	G	A	MI.12948	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	94	32	G	S	Ggc/Agc	-5.27	0	0	probably_damaging	1	neutral	0.4	neutral	4.47	neutral	-1.82	deleterious	-5.54	medium_impact	2.38	0.38	damaging	0.02	damaging	4.01	23.60	deleterious	0.05	0.35	0.5	neutral	0.84	disease	0.59	disease	0.68	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.11	medium_impact	0.86	medium_impact	0.62	0.8	NA	NA	0.5	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4563	4563	G	C	MI.12949	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	94	32	G	R	Ggc/Cgc	-5.27	0	0	probably_damaging	1	neutral	0.35	neutral	4.35	deleterious	-3.81	deleterious	-7.39	medium_impact	3.4	0.46	damaging	0.02	damaging	3.74	23.30	deleterious	0.02	0.35	0.43	neutral	0.92	disease	0.75	disease	0.73	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.06	medium_impact	1.72	medium_impact	0.34	0.8	NA	NA	0.38	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9135	9135	A	C	MI.1295	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	609	203	E	D	gaA/gaC	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	3.52	deleterious	-3.76	deleterious	-2.67	high_impact	4.58	0.55	damaging	0.54	neutral	3.83	23.40	deleterious	0.44	0.65	NA	NA	0.79	disease	0.68	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.65	low_impact	-1.4	low_impact	2.83	high_impact	0.62	0.9	48.67	8.97	0.58	P	0.87	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4563	4563	G	T	MI.12950	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	94	32	G	C	Ggc/Tgc	-5.27	0	0	probably_damaging	1	neutral	0.18	neutral	4.33	deleterious	-4.38	deleterious	-8.31	medium_impact	2.56	0.48	damaging	0.02	damaging	3.93	23.50	deleterious	0.03	0.35	0.88	disease	0.92	disease	0.63	disease	0.66	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.16	medium_impact	1.01	medium_impact	0.23	0.8	NA	NA	0.3	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4564	4564	G	T	MI.12951	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	95	32	G	V	gGc/gTc	6.01	1	0	probably_damaging	1	neutral	0.5	neutral	4.41	neutral	-1.99	deleterious	-8.31	medium_impact	3.4	0.44	damaging	0.02	damaging	3.59	23.20	deleterious	0.03	0.35	0.64	disease	0.9	disease	0.66	disease	0.72	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.21	medium_impact	1.72	medium_impact	0.23	0.8	NA	NA	0.62	P	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4564	4564	G	A	MI.12952	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	95	32	G	D	gGc/gAc	6.01	1	0	probably_damaging	1	neutral	0.2	neutral	4.33	deleterious	-4.53	deleterious	-6.46	high_impact	3.94	0.49	damaging	0.02	damaging	3.74	23.30	deleterious	0.02	0.35	0.3	neutral	0.9	disease	0.75	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	-0.13	medium_impact	2.17	high_impact	0.20	0.8	NA	NA	0.59	P	0.95	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4564	4564	G	C	MI.12953	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	95	32	G	A	gGc/gCc	6.01	1	0	probably_damaging	1	neutral	0.51	neutral	4.44	neutral	-0.5	deleterious	-5.54	medium_impact	2.5	0.44	damaging	0.04	damaging	2.96	22.10	deleterious	0.09	0.35	0.5	neutral	0.78	disease	0.61	disease	0.66	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.22	medium_impact	0.96	medium_impact	0.44	0.8	NA	NA	0.59	P	0.74	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4566	4566	C	A	MI.12954	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	97	33	L	M	Cta/Ata	-15.63	0	0	probably_damaging	1	neutral	0.22	neutral	4.43	neutral	-2.06	neutral	-0.88	low_impact	1.5	0.81	neutral	0.22	damaging	3.58	23.20	deleterious	0.13	0.4	0.28	neutral	0.59	disease	0.58	disease	0.62	disease	2	1	deleterious	0.11	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	-0.1	medium_impact	0.12	medium_impact	0.61	0.8	0.86	12.13	0.3	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4566	4566	C	G	MI.12955	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	97	33	L	V	Cta/Gta	-15.63	0	0	probably_damaging	1	neutral	0.43	neutral	4.44	neutral	-1.86	neutral	-1.8	medium_impact	2.58	0.89	neutral	0.25	damaging	3.26	22.80	deleterious	0.09	0.35	0.44	neutral	0.69	disease	0.6	disease	0.63	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.14	medium_impact	1.03	medium_impact	0.59	0.8	0.86	12.13	0.29	N	0.43	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4567	4567	T	C	MI.12956	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	98	33	L	P	cTa/cCa	-0.43	0	0	probably_damaging	1	neutral	0.15	neutral	4.37	deleterious	-4.74	deleterious	-5.01	medium_impact	3.13	0.79	neutral	0.17	damaging	3.75	23.30	deleterious	0.02	0.35	0.76	disease	0.85	disease	0.72	disease	0.71	disease	4	1	deleterious	0.08	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.21	medium_impact	1.49	medium_impact	0.29	0.8	0.86	12.13	0.28	N	0.95	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4567	4567	T	G	MI.12957	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	98	33	L	R	cTa/cGa	-0.43	0	0	probably_damaging	1	neutral	0.26	neutral	4.37	deleterious	-4.18	deleterious	-4.08	medium_impact	3.48	0.78	neutral	0.16	damaging	4.02	23.60	deleterious	0.02	0.35	0.65	disease	0.92	disease	0.72	disease	0.74	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	-0.04	medium_impact	1.79	medium_impact	0.28	0.8	0.86	12.13	0.32	N	0.96	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4567	4567	T	A	MI.12958	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	98	33	L	Q	cTa/cAa	-0.43	0	0	probably_damaging	1	neutral	0.23	neutral	4.37	deleterious	-4.31	deleterious	-4.08	medium_impact	3.48	0.79	neutral	0.21	damaging	3.92	23.50	deleterious	0.02	0.35	0.23	neutral	0.83	disease	0.6	disease	0.66	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.08	medium_impact	1.79	medium_impact	0.34	0.8	0.86	12.13	0.31	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4569	4569	G	A	MI.12959	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	100	34	E	K	Gaa/Aaa	-1.12	0	0	probably_damaging	1	neutral	0.29	neutral	3.14	deleterious	-6.47	deleterious	-3.69	high_impact	3.66	0.62	neutral	0.06	damaging	4.32	24.00	deleterious	0.02	0.35	0.84	disease	0.91	disease	0.85	disease	0.72	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	-0.01	medium_impact	1.94	medium_impact	0.58	0.8	0.29	6.56	0.45	N	0.98	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9135	9135	A	T	MI.1296	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	609	203	E	D	gaA/gaT	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	3.52	deleterious	-3.76	deleterious	-2.67	high_impact	4.58	0.55	damaging	0.54	neutral	3.98	23.60	deleterious	0.44	0.65	NA	NA	0.79	disease	0.68	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.65	low_impact	-1.4	low_impact	2.83	high_impact	0.62	0.9	48.67	8.97	0.58	P	0.87	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4569	4569	G	C	MI.12960	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	100	34	E	Q	Gaa/Caa	-1.12	0	0	probably_damaging	1	neutral	0.3	neutral	3.14	deleterious	-6.46	deleterious	-2.77	high_impact	4	0.67	neutral	0.07	damaging	3.15	22.60	deleterious	0.05	0.35	0.86	disease	0.8	disease	0.74	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0	medium_impact	2.22	high_impact	0.56	0.8	0.29	6.56	0.4	N	0.88	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4570	4570	A	G	MI.12961	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	101	34	E	G	gAa/gGa	6.01	1	0	probably_damaging	1	neutral	0.34	neutral	3.18	deleterious	-5.24	deleterious	-6.46	high_impact	4	0.64	neutral	0.1	damaging	3.88	23.50	deleterious	0.02	0.35	0.86	disease	0.81	disease	0.78	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.05	medium_impact	2.22	high_impact	0.13	0.8	0.29	6.56	0.69	P	0.45	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4570	4570	A	T	MI.12962	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	101	34	E	V	gAa/gTa	6.01	1	0	probably_damaging	1	neutral	0.51	neutral	3.12	deleterious	-8.28	deleterious	-6.46	high_impact	3.66	0.68	neutral	0.08	damaging	3.84	23.40	deleterious	0.02	0.35	0.92	disease	0.91	disease	0.79	disease	0.7	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	0.22	medium_impact	1.94	medium_impact	0.23	0.8	0.29	6.56	0.64	P	0.81	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4570	4570	A	C	MI.12963	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	101	34	E	A	gAa/gCa	6.01	1	0	probably_damaging	1	neutral	0.51	neutral	3.14	deleterious	-6.58	deleterious	-5.54	high_impact	3.66	0.69	neutral	0.12	damaging	3.35	22.90	deleterious	0.02	0.35	0.42	neutral	0.83	disease	0.77	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.22	medium_impact	1.94	medium_impact	0.28	0.8	0.29	6.56	0.57	P	0.73	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4571	4571	A	C	MI.12964	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	102	34	E	D	gaA/gaC	8.55	1	0	probably_damaging	1	neutral	0.21	neutral	3.28	deleterious	-3.93	deleterious	-2.77	high_impact	3.66	0.68	neutral	0.06	damaging	3.56	23.10	deleterious	0.07	0.35	0.75	disease	0.77	disease	0.75	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.11	medium_impact	1.94	medium_impact	0.51	0.8	0.29	6.56	0.66	P	0.85	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4571	4571	A	T	MI.12965	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	102	34	E	D	gaA/gaT	8.55	1	0	probably_damaging	1	neutral	0.21	neutral	3.28	deleterious	-3.93	deleterious	-2.77	high_impact	3.66	0.68	neutral	0.06	damaging	3.71	23.30	deleterious	0.07	0.35	0.75	disease	0.77	disease	0.75	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.11	medium_impact	1.94	medium_impact	0.51	0.8	0.29	6.56	0.68	P	0.85	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4572	4572	A	C	MI.12966	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	103	35	M	L	Ata/Cta	3.25	1	0	benign	0.02	neutral	1	neutral	4.85	neutral	2.15	neutral	-1.96	neutral_impact	0.18	0.89	neutral	0.83	neutral	1.74	14.62	neutral	0.24	0.45	0.29	neutral	0.76	disease	0.34	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.21	neutral	0.75	medium_impact	1.87	high_impact	-0.99	medium_impact	0.60	0.8	0.86	7.41	0.41	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4572	4572	A	T	MI.12967	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	103	35	M	L	Ata/Tta	3.25	1	0	benign	0.02	neutral	1	neutral	4.85	neutral	2.15	neutral	-1.96	neutral_impact	0.18	0.89	neutral	0.83	neutral	1.80	15.00	deleterious	0.24	0.45	0.29	neutral	0.76	disease	0.34	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.21	neutral	0.75	medium_impact	1.87	high_impact	-0.99	medium_impact	0.60	0.8	0.86	7.41	0.42	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4572	4572	A	G	MI.12968	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	103	35	M	V	Ata/Gta	3.25	1	0	benign	0.28	neutral	0.54	neutral	4.81	neutral	1.07	deleterious	-2.77	low_impact	1.44	0.93	neutral	0.37	neutral	2.32	18.33	deleterious	0.21	0.45	0.2	neutral	0.84	disease	0.51	disease	0.22	neutral	6	0.36	neutral	0.63	deleterious	-6	neutral	0.46	deleterious	-0.42	medium_impact	0.25	medium_impact	0.07	medium_impact	0.54	0.8	0.86	7.41	0.35	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4573	4573	T	C	MI.12969	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	104	35	M	T	aTa/aCa	1.41	1	0	possibly_damaging	0.74	neutral	0.41	neutral	4.68	neutral	-0.39	deleterious	-4.86	medium_impact	2.31	0.81	neutral	0.15	damaging	2.86	21.60	deleterious	0.07	0.35	0.37	neutral	0.85	disease	0.61	disease	0.74	disease	5	0.74	neutral	0.34	neutral	0	NA	0.71	deleterious	-1.21	low_impact	0.12	medium_impact	0.8	medium_impact	0.15	0.8	0.86	7.41	0.36	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9136	9136	A	G	MI.1297	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	610	204	I	V	Atc/Gtc	-0.33	0	0	benign	0	neutral	1	neutral	4.27	neutral	-0.78	neutral	-0.45	neutral_impact	0.16	0.81	neutral	0.79	neutral	-1.59	0.00	neutral	0.62	0.7	NA	NA	0.11	neutral	0.28	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	1.98	high_impact	-0.96	medium_impact	0.31	0.9	27.88	21.96	0.27	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4573	4573	T	A	MI.12970	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	104	35	M	K	aTa/aAa	1.41	1	0	possibly_damaging	0.74	neutral	0.27	neutral	4.63	neutral	-2.44	deleterious	-5.17	medium_impact	2.86	0.83	neutral	0.13	damaging	3.93	23.50	deleterious	0.02	0.35	0.64	disease	0.94	disease	0.67	disease	0.81	disease	6	0.81	neutral	0.27	neutral	0	NA	0.80	deleterious	-1.21	low_impact	-0.03	medium_impact	1.26	medium_impact	0.15	0.8	0.86	7.41	0.45	N	0.89	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4574	4574	A	T	MI.12971	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	105	35	M	I	atA/atT	7.4	1	0	benign	0.39	neutral	0.92	neutral	4.71	neutral	1.08	deleterious	-2.59	neutral_impact	-0.36	0.89	neutral	0.89	neutral	1.40	12.81	neutral	0.21	0.45	0.23	neutral	0.34	neutral	0.23	neutral	0.44	neutral	1	0.31	neutral	0.77	deleterious	-6	neutral	0.51	deleterious	-0.62	medium_impact	0.8	medium_impact	-1.45	low_impact	0.58	0.8	0.86	7.41	0.55	N	0.40	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4574	4574	A	C	MI.12972	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	105	35	M	I	atA/atC	7.4	1	0	benign	0.39	neutral	0.92	neutral	4.71	neutral	1.08	deleterious	-2.59	neutral_impact	-0.36	0.89	neutral	0.89	neutral	1.33	12.41	neutral	0.21	0.45	0.23	neutral	0.34	neutral	0.23	neutral	0.44	neutral	1	0.31	neutral	0.77	deleterious	-6	neutral	0.51	deleterious	-0.62	medium_impact	0.8	medium_impact	-1.45	low_impact	0.58	0.8	0.86	7.41	0.54	N	0.40	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4575	4575	A	G	MI.12973	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	106	36	N	D	Aac/Gac	-3.65	0	0	probably_damaging	1	neutral	0.24	neutral	4.6	neutral	-1.24	deleterious	-4.49	high_impact	3.63	0.83	neutral	0.45	neutral	3.68	23.30	deleterious	0.25	0.45	0.75	disease	0.8	disease	0.76	disease	0.72	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.07	medium_impact	1.91	medium_impact	0.20	0.8	1.15	8.05	0.4	N	0.70	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4575	4575	A	C	MI.12974	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	106	36	N	H	Aac/Cac	-3.65	0	0	probably_damaging	1	neutral	0.55	neutral	4.59	neutral	-1.9	deleterious	-4.52	high_impact	3.98	0.87	neutral	0.32	neutral	2.92	21.90	deleterious	0.17	0.45	0.74	disease	0.86	disease	0.76	disease	0.71	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.26	medium_impact	2.21	high_impact	0.20	0.8	1.15	8.05	0.34	N	0.49	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4575	4575	A	T	MI.12975	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	106	36	N	Y	Aac/Tac	-3.65	0	0	probably_damaging	1	neutral	1	neutral	4.59	neutral	-1.81	deleterious	-7.22	high_impact	3.98	0.83	neutral	0.37	neutral	3.52	23.10	deleterious	0.04	0.35	0.64	disease	0.9	disease	0.71	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.83	deleterious	-3.54	low_impact	1.87	high_impact	2.21	high_impact	0.14	0.8	1.15	8.05	0.28	N	0.91	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4576	4576	A	T	MI.12976	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	107	36	N	I	aAc/aTc	6.71	0.94	0	probably_damaging	1	neutral	0.43	neutral	4.62	neutral	-0.62	deleterious	-8.11	high_impact	3.98	0.87	neutral	0.54	neutral	3.66	23.20	deleterious	0.05	0.35	0.25	neutral	0.94	disease	0.66	disease	0.75	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	0.14	medium_impact	2.21	high_impact	0.11	0.8	1.15	8.05	0.59	P	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4576	4576	A	G	MI.12977	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	107	36	N	S	aAc/aGc	6.71	0.94	0	probably_damaging	1	neutral	0.45	neutral	4.81	neutral	1.75	deleterious	-4.35	medium_impact	2.34	0.9	neutral	0.81	neutral	1.66	14.20	neutral	0.37	0.5	0.4	neutral	0.78	disease	0.47	neutral	0.21	neutral	6	1	deleterious	0.23	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.16	medium_impact	0.83	medium_impact	0.21	0.8	1.15	8.05	0.53	P	0.22	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4576	4576	A	C	MI.12978	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	107	36	N	T	aAc/aCc	6.71	0.94	0	probably_damaging	1	neutral	0.43	neutral	4.62	neutral	-0.42	deleterious	-5.34	medium_impact	3.29	0.84	neutral	0.49	neutral	3.22	22.70	deleterious	0.18	0.45	0.49	neutral	0.84	disease	0.67	disease	0.71	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.14	medium_impact	1.63	medium_impact	0.22	0.8	1.15	8.05	0.54	P	0.58	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4577	4577	C	A	MI.12979	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	108	36	N	K	aaC/aaA	1.41	0.67	0.01	probably_damaging	1	neutral	0.34	neutral	4.63	neutral	-0.39	deleterious	-5.38	high_impact	3.98	0.85	neutral	0.36	neutral	4.32	24.00	deleterious	0.16	0.45	0.62	disease	0.89	disease	0.73	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	0.05	medium_impact	2.21	high_impact	0.33	0.8	1.15	8.05	0.38	N	0.83	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9136	9136	A	T	MI.1298	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	610	204	I	F	Atc/Ttc	-0.33	0	0	benign	0.39	neutral	0.46	neutral	4.18	neutral	-1.6	neutral	-0.56	low_impact	0.9	0.86	neutral	0.95	neutral	1.10	11.19	neutral	0.44	0.65	NA	NA	0.6	disease	0.34	neutral	0.46	neutral	1	0.48	neutral	0.54	deleterious	-6	neutral	0.62	deleterious	-0.57	medium_impact	0.25	medium_impact	-0.33	medium_impact	0.56	0.9	27.88	21.96	0.31	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4577	4577	C	G	MI.12980	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	108	36	N	K	aaC/aaG	1.41	0.67	0.01	probably_damaging	1	neutral	0.34	neutral	4.63	neutral	-0.39	deleterious	-5.38	high_impact	3.98	0.85	neutral	0.36	neutral	3.82	23.40	deleterious	0.16	0.45	0.62	disease	0.89	disease	0.73	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	0.05	medium_impact	2.21	high_impact	0.33	0.8	1.15	8.05	0.38	N	0.83	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4578	4578	A	C	MI.12981	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	109	37	M	L	Atg/Ctg	-2.73	0	0	benign	0.24	neutral	0.94	neutral	4.98	neutral	2.45	neutral	-2.04	neutral_impact	-0.21	0.91	neutral	0.89	neutral	1.59	13.80	neutral	0.29	0.45	0.23	neutral	0.77	disease	0.4	neutral	0.21	neutral	6	0.15	neutral	0.85	deleterious	-6	neutral	0.45	deleterious	-0.34	medium_impact	0.87	medium_impact	-1.32	low_impact	0.24	0.8	0.86	7.47	0.28	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4578	4578	A	T	MI.12982	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	109	37	M	L	Atg/Ttg	-2.73	0	0	benign	0.24	neutral	0.94	neutral	4.98	neutral	2.45	neutral	-2.04	neutral_impact	-0.21	0.91	neutral	0.89	neutral	1.60	13.87	neutral	0.29	0.45	0.23	neutral	0.77	disease	0.4	neutral	0.21	neutral	6	0.15	neutral	0.85	deleterious	-6	neutral	0.45	deleterious	-0.34	medium_impact	0.87	medium_impact	-1.32	low_impact	0.24	0.8	0.86	7.47	0.29	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4578	4578	A	G	MI.12983	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	109	37	M	V	Atg/Gtg	-2.73	0	0	benign	0.34	neutral	0.66	neutral	4.74	neutral	1.16	deleterious	-3.14	medium_impact	2.31	0.82	neutral	0.53	neutral	2.40	18.82	deleterious	0.21	0.45	0.27	neutral	0.82	disease	0.62	disease	0.73	disease	5	0.28	neutral	0.66	deleterious	-3	neutral	0.50	deleterious	-0.53	medium_impact	0.37	medium_impact	0.8	medium_impact	0.26	0.8	0.86	7.47	0.25	N	0.65	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4579	4579	T	A	MI.12984	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	110	37	M	K	aTg/aAg	1.87	0.54	0	possibly_damaging	0.54	neutral	0.32	neutral	4.58	neutral	-1.96	deleterious	-5.08	medium_impact	2.31	0.82	neutral	0.36	neutral	3.92	23.50	deleterious	0.03	0.35	0.65	disease	0.92	disease	0.71	disease	0.76	disease	5	0.67	neutral	0.39	neutral	0	NA	0.76	deleterious	-0.86	medium_impact	0.03	medium_impact	0.8	medium_impact	0.12	0.8	0.86	7.47	0.33	N	0.87	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4579	4579	T	C	MI.12985	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	110	37	M	T	aTg/aCg	1.87	0.54	0	benign	0.04	neutral	1	neutral	4.65	neutral	0.14	deleterious	-4.73	neutral_impact	-0.78	0.86	neutral	0.9	neutral	0.96	10.43	neutral	0.1	0.4	0.25	neutral	0.21	neutral	0.32	neutral	0.33	neutral	3	0.04	neutral	0.98	deleterious	-6	neutral	0.19	neutral	0.47	medium_impact	1.87	high_impact	-1.8	low_impact	0.14	0.8	0.86	7.47	0.25	N	0.35	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4580	4580	G	C	MI.12986	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	111	37	M	I	atG/atC	3.48	0.59	0.12	benign	0.42	neutral	0.61	neutral	4.78	neutral	1.41	deleterious	-3.05	low_impact	1.62	0.83	neutral	0.42	neutral	3.36	22.90	deleterious	0.21	0.45	0.37	neutral	0.84	disease	0.6	disease	0.75	disease	5	0.37	neutral	0.6	deleterious	-6	neutral	0.63	deleterious	-0.67	medium_impact	0.32	medium_impact	0.22	medium_impact	0.31	0.8	0.86	7.47	0.28	N	0.72	disease_causing	1	0.06	rs28357975	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4580	4580	G	T	MI.12987	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	111	37	M	I	atG/atT	3.48	0.59	0.12	benign	0.42	neutral	0.61	neutral	4.78	neutral	1.41	deleterious	-3.05	low_impact	1.62	0.83	neutral	0.42	neutral	3.48	23.10	deleterious	0.21	0.45	0.37	neutral	0.84	disease	0.6	disease	0.75	disease	5	0.37	neutral	0.6	deleterious	-6	neutral	0.63	deleterious	-0.67	medium_impact	0.32	medium_impact	0.22	medium_impact	0.31	0.8	0.86	7.47	0.28	N	0.72	disease_causing	1	0.06	rs28357975	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4581	4581	C	G	MI.12988	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	112	38	L	V	Cta/Gta	-3.65	0	0	probably_damaging	1	neutral	0.07	neutral	4.62	neutral	-1.84	neutral	-2.42	medium_impact	3.06	0.87	neutral	0.14	damaging	3.25	22.80	deleterious	0.08	0.35	0.51	disease	0.71	disease	0.66	disease	0.66	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.42	medium_impact	1.43	medium_impact	0.55	0.8	0.58	7.04	0.36	N	0.77	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4581	4581	C	A	MI.12989	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	112	38	L	M	Cta/Ata	-3.65	0	0	probably_damaging	1	neutral	0.16	neutral	4.55	deleterious	-3.63	neutral	-1.39	low_impact	1	0.92	neutral	0.88	neutral	2.39	18.73	deleterious	0.1	0.4	0.6	disease	0.59	disease	0.33	neutral	0.24	neutral	5	1	deleterious	0.08	neutral	-2	neutral	0.77	deleterious	-3.54	low_impact	-0.19	medium_impact	-0.3	medium_impact	0.49	0.8	0.58	7.04	0.43	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9136	9136	A	C	MI.1299	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	610	204	I	L	Atc/Ctc	-0.33	0	0	benign	0.03	neutral	0.37	neutral	4.45	neutral	0.26	neutral	-0.65	neutral_impact	0.41	0.89	neutral	0.91	neutral	0.13	3.93	deleterious	0.42	0.65	NA	NA	0.43	neutral	0.24	neutral	0.2	neutral	6	0.61	neutral	0.67	deleterious	-6	neutral	0.23	neutral	0.68	medium_impact	0.16	medium_impact	-0.75	medium_impact	0.51	0.9	27.88	21.96	0.38	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4582	4582	T	C	MI.12990	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	113	38	L	P	cTa/cCa	-1.58	0	0	probably_damaging	1	deleterious	0.02	neutral	4.66	deleterious	-4.81	deleterious	-5.96	medium_impact	3.27	0.88	neutral	0.09	damaging	3.76	23.30	deleterious	0.01	0.35	0.73	disease	0.87	disease	0.78	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.89	deleterious	-3.54	low_impact	-0.73	medium_impact	1.61	medium_impact	0.13	0.8	0.58	7.04	0.4	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4582	4582	T	A	MI.12991	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	113	38	L	Q	cTa/cAa	-1.58	0	0	probably_damaging	1	deleterious	0.03	neutral	4.5	deleterious	-5.11	deleterious	-5	high_impact	3.62	0.89	neutral	0.13	damaging	4.00	23.60	deleterious	0.01	0.35	0.54	disease	0.87	disease	0.67	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-0.63	medium_impact	1.9	medium_impact	0.19	0.8	0.58	7.04	0.41	N	0.99	polymorphism	1	0.30	rs28393930	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4582	4582	T	G	MI.12992	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	113	38	L	R	cTa/cGa	-1.58	0	0	probably_damaging	1	deleterious	0.04	neutral	4.5	deleterious	-4.93	deleterious	-5.04	high_impact	3.62	0.86	neutral	0.09	damaging	4.04	23.70	deleterious	0.01	0.35	0.55	disease	0.92	disease	0.78	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-0.56	medium_impact	1.9	medium_impact	0.08	0.8	0.58	7.04	0.39	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4584	4584	G	C	MI.12993	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	115	39	A	P	Gct/Cct	-4.35	0	0	probably_damaging	1	neutral	0.22	neutral	4.55	neutral	-2.86	deleterious	-4.2	medium_impact	3	0.82	neutral	0.11	damaging	3.64	23.20	deleterious	0.03	0.35	0.73	disease	0.87	disease	0.74	disease	0.72	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.88	deleterious	-3.54	low_impact	-0.1	medium_impact	1.38	medium_impact	0.58	0.8	0.29	6.69	0.3	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4584	4584	G	A	MI.12994	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	115	39	A	T	Gct/Act	-4.35	0	0	probably_damaging	1	neutral	0.41	neutral	4.68	neutral	0.43	deleterious	-2.94	medium_impact	2.64	0.9	neutral	0.57	neutral	4.00	23.60	deleterious	0.1	0.4	0.46	neutral	0.81	disease	0.53	disease	0.54	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.12	medium_impact	1.08	medium_impact	0.77	0.85	0.29	6.69	0.41	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4584	4584	G	T	MI.12995	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	115	39	A	S	Gct/Tct	-4.35	0	0	probably_damaging	1	neutral	0.54	neutral	4.88	neutral	1.74	neutral	-2.15	low_impact	0.98	0.92	neutral	0.34	neutral	3.48	23.10	deleterious	0.23	0.45	0.4	neutral	0.77	disease	0.36	neutral	0.19	neutral	6	1	deleterious	0.27	neutral	-2	neutral	0.80	deleterious	-3.54	low_impact	0.25	medium_impact	-0.32	medium_impact	0.54	0.8	0.29	6.69	0.3	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4585	4585	C	A	MI.12996	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	116	39	A	D	gCt/gAt	2.56	0.98	0	probably_damaging	1	neutral	0.2	neutral	4.54	deleterious	-3.17	deleterious	-4.94	medium_impact	3.13	0.89	neutral	0.1	damaging	4.42	24.20	deleterious	0.01	0.35	0.61	disease	0.9	disease	0.74	disease	0.73	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.13	medium_impact	1.49	medium_impact	0.31	0.8	0.29	6.69	0.59	P	0.95	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4585	4585	C	T	MI.12997	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	116	39	A	V	gCt/gTt	2.56	0.98	0	probably_damaging	1	neutral	0.53	neutral	4.66	neutral	0.22	deleterious	-3.41	medium_impact	2.64	0.85	neutral	0.12	damaging	4.25	23.90	deleterious	0.06	0.35	0.48	neutral	0.85	disease	0.64	disease	0.7	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.24	medium_impact	1.08	medium_impact	0.77	0.85	0.29	6.69	0.4	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4585	4585	C	G	MI.12998	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	116	39	A	G	gCt/gGt	2.56	0.98	0	probably_damaging	1	neutral	0.36	neutral	4.55	neutral	-2.33	deleterious	-3.39	low_impact	1.9	0.9	neutral	0.13	damaging	3.79	23.40	deleterious	0.19	0.45	0.65	disease	0.76	disease	0.62	disease	0.66	disease	3	1	deleterious	0.18	neutral	-2	neutral	0.81	deleterious	-3.54	low_impact	0.07	medium_impact	0.46	medium_impact	0.68	0.85	0.29	6.69	0.53	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4587	4587	T	C	MI.12999	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	118	40	F	L	Ttt/Ctt	-10.56	0	0	benign	0.43	neutral	0.4	neutral	4.68	neutral	0.17	neutral	0.75	low_impact	1.43	0.9	neutral	0.52	neutral	3.79	23.40	deleterious	0.19	0.45	0.28	neutral	0.6	disease	0.25	neutral	0.21	neutral	6	0.55	neutral	0.49	deleterious	-6	neutral	0.51	deleterious	-0.69	medium_impact	0.11	medium_impact	0.06	medium_impact	0.66	0.8	NA	NA	0.37	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8532	8532	C	G	MI.13	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	6	2	N	K	aaC/aaG	1.75	0.87	0	probably_damaging	0.97	neutral	0.07	neutral	4.69	neutral	0.02	deleterious	-3.41	medium_impact	2.6	0.87	neutral	0.44	neutral	6.13	28.40	deleterious	0.78	0.8	0.51	disease	0.42	neutral	0.25	neutral	0.38	neutral	3	0.99	deleterious	0.05	neutral	1	deleterious	0.68	deleterious	-2.19	low_impact	-0.34	medium_impact	1.13	medium_impact	0.26	0.9	41.59	7.23	0.39	N	1.00	disease_causing	0.89	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8587	8587	G	A	MI.130	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	61	21	V	M	Gta/Ata	-8.2	0	0	possibly_damaging	0.88	neutral	0.28	neutral	4.25	neutral	-2.02	neutral	-0.88	neutral_impact	0.11	0.92	neutral	0.9	neutral	2.08	16.74	deleterious	0.39	0.65	0.65	disease	0.19	neutral	0.27	neutral	0.45	neutral	1	0.91	neutral	0.2	neutral	-3	neutral	0.63	deleterious	-1.58	low_impact	0.06	medium_impact	-1	low_impact	0.69	0.9	22.57	20.88	0.48	N	0.70	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9137	9137	T	G	MI.1300	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	611	204	I	S	aTc/aGc	-0.1	0	0	benign	0.16	neutral	0.46	neutral	4.15	neutral	-2.2	deleterious	-3.59	low_impact	1.62	0.81	neutral	0.5	neutral	2.85	21.60	deleterious	0.35	0.65	NA	NA	0.61	disease	0.56	disease	0.46	neutral	1	0.45	neutral	0.65	deleterious	-6	neutral	0.38	neutral	-0.07	medium_impact	0.25	medium_impact	0.29	medium_impact	0.37	0.9	27.88	21.96	0.27	N	0.46	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4587	4587	T	A	MI.13000	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	118	40	F	I	Ttt/Att	-10.56	0	0	benign	0.1	neutral	1	neutral	4.51	neutral	-1.07	neutral	1.91	neutral_impact	-0.86	0.87	neutral	0.92	neutral	1.51	13.36	neutral	0.14	0.4	0.19	neutral	0.22	neutral	0.14	neutral	0.36	neutral	3	0.1	neutral	0.95	deleterious	-6	neutral	0.21	neutral	0.08	medium_impact	1.87	high_impact	-1.87	low_impact	0.41	0.8	NA	NA	0.34	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4587	4587	T	G	MI.13001	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	118	40	F	V	Ttt/Gtt	-10.56	0	0	benign	0.43	neutral	0.24	neutral	4.5	neutral	-1.12	neutral	1.23	low_impact	1.15	0.9	neutral	0.94	neutral	2.74	21.00	deleterious	0.07	0.35	0.31	neutral	0.73	disease	0.28	neutral	0.21	neutral	6	0.72	neutral	0.41	neutral	-6	neutral	0.58	deleterious	-0.69	medium_impact	-0.07	medium_impact	-0.18	medium_impact	0.32	0.8	NA	NA	0.42	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4588	4588	T	G	MI.13002	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	119	40	F	C	tTt/tGt	4.63	1	0	probably_damaging	0.98	neutral	0.06	neutral	4.38	deleterious	-4.76	neutral	-1.84	medium_impact	2.71	0.79	neutral	0.22	damaging	3.93	23.50	deleterious	0.03	0.35	0.68	disease	0.79	disease	0.55	disease	0.7	disease	4	0.99	deleterious	0.04	neutral	1	deleterious	0.79	deleterious	-2.34	low_impact	-0.46	medium_impact	1.14	medium_impact	0.21	0.8	NA	NA	0.52	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4588	4588	T	A	MI.13003	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	119	40	F	Y	tTt/tAt	4.63	1	0	possibly_damaging	0.89	neutral	0.16	neutral	4.81	neutral	0.75	neutral	-1.15	medium_impact	2.16	0.89	neutral	0.26	damaging	4.03	23.70	deleterious	0.16	0.45	0.55	disease	0.62	disease	0.51	disease	0.49	neutral	0	0.94	neutral	0.14	neutral	0	NA	0.75	deleterious	-1.63	low_impact	-0.19	medium_impact	0.67	medium_impact	0.57	0.8	NA	NA	0.63	P	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4588	4588	T	C	MI.13004	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	119	40	F	S	tTt/tCt	4.63	1	0	probably_damaging	0.9	neutral	0.51	neutral	4.39	deleterious	-3.54	neutral	-2.49	medium_impact	2.71	0.76	neutral	0.21	damaging	4.02	23.60	deleterious	0.04	0.35	0.32	neutral	0.74	disease	0.51	disease	0.54	disease	1	0.89	neutral	0.31	neutral	1	deleterious	0.74	deleterious	-1.67	low_impact	0.22	medium_impact	1.14	medium_impact	0.29	0.8	NA	NA	0.51	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4589	4589	T	G	MI.13005	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	120	40	F	L	ttT/ttG	4.63	1	0	benign	0.43	neutral	0.4	neutral	4.68	neutral	0.17	neutral	0.75	low_impact	1.43	0.9	neutral	0.52	neutral	4.10	23.70	deleterious	0.19	0.45	0.28	neutral	0.6	disease	0.25	neutral	0.21	neutral	6	0.55	neutral	0.49	deleterious	-6	neutral	0.51	deleterious	-0.69	medium_impact	0.11	medium_impact	0.06	medium_impact	0.66	0.8	NA	NA	0.57	P	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4589	4589	T	A	MI.13006	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	120	40	F	L	ttT/ttA	4.63	1	0	benign	0.43	neutral	0.4	neutral	4.68	neutral	0.17	neutral	0.75	low_impact	1.43	0.9	neutral	0.52	neutral	4.23	23.90	deleterious	0.19	0.45	0.28	neutral	0.6	disease	0.25	neutral	0.21	neutral	6	0.55	neutral	0.49	deleterious	-6	neutral	0.51	deleterious	-0.69	medium_impact	0.11	medium_impact	0.06	medium_impact	0.66	0.8	NA	NA	0.57	P	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4590	4590	A	C	MI.13007	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	121	41	I	L	Att/Ctt	-8.49	0	0	benign	0.12	neutral	0.5	neutral	4.74	neutral	-0.38	neutral	-1.69	low_impact	1.2	0.85	neutral	0.54	neutral	3.57	23.20	deleterious	0.27	0.45	0.22	neutral	0.37	neutral	0.31	neutral	0.43	neutral	2	0.42	neutral	0.69	deleterious	-6	neutral	0.31	neutral	-0.01	medium_impact	0.21	medium_impact	-0.13	medium_impact	0.57	0.8	0.29	7.27	0.33	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4590	4590	A	G	MI.13008	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	121	41	I	V	Att/Gtt	-8.49	0	0	benign	0.02	neutral	0.28	neutral	4.51	neutral	-0.21	neutral	-0.64	low_impact	1.89	0.91	neutral	0.93	neutral	1.81	15.07	deleterious	0.38	0.5	0.4	neutral	0.45	neutral	0.41	neutral	0.41	neutral	2	0.71	neutral	0.63	deleterious	-6	neutral	0.19	neutral	0.75	medium_impact	-0.02	medium_impact	0.45	medium_impact	0.53	0.8	0.29	7.27	0.42	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4590	4590	A	T	MI.13009	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	121	41	I	F	Att/Ttt	-8.49	0	0	possibly_damaging	0.66	neutral	0.59	neutral	4.44	neutral	-0.96	deleterious	-3.47	medium_impact	3.43	0.86	neutral	0.41	neutral	3.60	23.20	deleterious	0.1	0.4	0.62	disease	0.78	disease	0.67	disease	0.68	disease	4	0.61	neutral	0.47	neutral	0	NA	0.75	deleterious	-1.06	low_impact	0.3	medium_impact	1.74	medium_impact	0.50	0.8	0.29	7.27	0.3	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9137	9137	T	A	MI.1301	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	611	204	I	N	aTc/aAc	-0.1	0	0	benign	0.32	deleterious	0.01	neutral	4.09	deleterious	-4.21	deleterious	-4.51	medium_impact	3.4	0.81	neutral	0.45	neutral	4.51	24.30	deleterious	0.31	0.65	NA	NA	0.76	disease	0.57	disease	0.74	disease	5	0.99	deleterious	0.35	neutral	1	deleterious	0.60	deleterious	-0.45	medium_impact	-0.84	medium_impact	1.82	medium_impact	0.35	0.9	27.88	21.96	0.36	N	0.63	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4591	4591	T	G	MI.13010	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	122	41	I	S	aTt/aGt	3.02	0.98	0	benign	0.37	neutral	0.29	neutral	4.38	neutral	-2.62	deleterious	-4.87	high_impact	3.78	0.86	neutral	0.44	neutral	4.04	23.70	deleterious	0.02	0.35	0.55	disease	0.86	disease	0.68	disease	0.71	disease	4	0.66	neutral	0.46	neutral	-2	neutral	0.63	deleterious	-0.59	medium_impact	-0.01	medium_impact	2.04	high_impact	0.25	0.8	0.29	7.27	0.59	P	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4591	4591	T	A	MI.13011	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	122	41	I	N	aTt/aAt	3.02	0.98	0	possibly_damaging	0.76	neutral	0.11	neutral	4.36	deleterious	-3.95	deleterious	-5.8	high_impact	3.78	0.88	neutral	0.41	neutral	4.18	23.80	deleterious	0.05	0.35	0.61	disease	0.85	disease	0.7	disease	0.71	disease	4	0.92	neutral	0.18	neutral	1	deleterious	0.76	deleterious	-1.26	low_impact	-0.3	medium_impact	2.04	high_impact	0.33	0.8	0.29	7.27	0.62	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4591	4591	T	C	MI.13012	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	122	41	I	T	aTt/aCt	3.02	0.98	0	benign	0.03	neutral	0.19	neutral	4.4	neutral	-2.16	deleterious	-3.63	medium_impact	2.34	0.98	neutral	0.69	neutral	2.06	16.58	deleterious	0.04	0.35	0.53	disease	0.75	disease	0.59	disease	0.46	neutral	1	0.8	neutral	0.58	deleterious	-3	neutral	0.29	neutral	0.59	medium_impact	-0.14	medium_impact	0.83	medium_impact	0.24	0.8	0.29	7.27	0.5	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4592	4592	T	A	MI.13013	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	123	41	I	M	atT/atA	5.55	0.99	0	benign	0.12	neutral	0.22	neutral	4.38	neutral	-2.37	neutral	-2.47	medium_impact	2.23	0.92	neutral	0.6	neutral	3.61	23.20	deleterious	0.14	0.4	0.62	disease	0.68	disease	0.52	disease	0.46	neutral	1	0.75	neutral	0.55	deleterious	-3	neutral	0.39	neutral	-0.01	medium_impact	-0.1	medium_impact	0.73	medium_impact	0.46	0.8	0.29	7.27	0.6	P	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4592	4592	T	G	MI.13014	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	123	41	I	M	atT/atG	5.55	0.99	0	benign	0.12	neutral	0.22	neutral	4.38	neutral	-2.37	neutral	-2.47	medium_impact	2.23	0.92	neutral	0.6	neutral	3.29	22.80	deleterious	0.14	0.4	0.62	disease	0.68	disease	0.52	disease	0.46	neutral	1	0.75	neutral	0.55	deleterious	-3	neutral	0.39	neutral	-0.01	medium_impact	-0.1	medium_impact	0.73	medium_impact	0.46	0.8	0.29	7.27	0.6	P	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4593	4593	C	T	MI.13015	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	124	42	P	S	Cca/Tca	-5.27	0	0	benign	0.14	neutral	0.52	neutral	4.64	neutral	-0.09	deleterious	-6.77	medium_impact	3.1	0.75	neutral	0.45	neutral	3.72	23.30	deleterious	0.1	0.4	0.77	disease	0.83	disease	0.72	disease	0.62	disease	2	0.39	neutral	0.69	deleterious	-3	neutral	0.51	deleterious	-0.08	medium_impact	0.23	medium_impact	1.47	medium_impact	0.13	0.8	NA	NA	0.28	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4593	4593	C	A	MI.13016	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	124	42	P	T	Cca/Aca	-5.27	0	0	possibly_damaging	0.76	neutral	0.4	neutral	4.62	neutral	-0.57	deleterious	-6.92	medium_impact	2.97	0.79	neutral	0.35	neutral	3.53	23.10	deleterious	0.07	0.35	0.79	disease	0.85	disease	0.76	disease	0.72	disease	4	0.77	neutral	0.32	neutral	0	NA	0.81	deleterious	-1.26	low_impact	0.11	medium_impact	1.36	medium_impact	0.43	0.8	NA	NA	0.3	N	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4593	4593	C	G	MI.13017	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	124	42	P	A	Cca/Gca	-5.27	0	0	possibly_damaging	0.66	neutral	0.53	neutral	4.63	neutral	-0.23	deleterious	-6.92	medium_impact	2.75	0.82	neutral	0.48	neutral	2.95	22.00	deleterious	0.08	0.35	0.75	disease	0.71	disease	0.75	disease	0.72	disease	4	0.62	neutral	0.44	neutral	0	NA	0.74	deleterious	-1.06	low_impact	0.24	medium_impact	1.17	medium_impact	0.52	0.8	NA	NA	0.26	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4594	4594	C	G	MI.13018	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	125	42	P	R	cCa/cGa	4.4	0.99	0	probably_damaging	0.93	neutral	0.34	neutral	4.59	neutral	-1.85	deleterious	-7.91	high_impact	4.07	0.83	neutral	0.36	neutral	3.44	23.00	deleterious	0.02	0.35	0.82	disease	0.91	disease	0.84	disease	0.75	disease	5	0.94	neutral	0.21	neutral	2	deleterious	0.87	deleterious	-1.83	low_impact	0.05	medium_impact	2.28	high_impact	0.31	0.8	NA	NA	0.67	P	0.56	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4594	4594	C	A	MI.13019	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	125	42	P	Q	cCa/cAa	4.4	0.99	0	probably_damaging	0.93	neutral	0.29	neutral	4.59	neutral	-1.97	deleterious	-6.98	high_impact	4.07	0.81	neutral	0.4	neutral	3.87	23.50	deleterious	0.06	0.35	0.82	disease	0.89	disease	0.77	disease	0.72	disease	4	0.94	neutral	0.18	neutral	2	deleterious	0.85	deleterious	-1.83	low_impact	-0.01	medium_impact	2.28	high_impact	0.29	0.8	NA	NA	0.64	P	0.83	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9137	9137	T	C	MI.1302	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	611	204	I	T	aTc/aCc	-0.1	0	0	benign	0.01	neutral	0.18	neutral	4.13	neutral	-2.57	deleterious	-2.72	low_impact	1.92	0.93	neutral	0.64	neutral	0.69	8.73	deleterious	0.58	0.7	NA	NA	0.41	neutral	0.36	neutral	0.16	neutral	7	0.82	neutral	0.59	deleterious	-6	neutral	0.16	neutral	1.14	medium_impact	-0.08	medium_impact	0.55	medium_impact	0.38	0.9	27.88	21.96	0.42	N	0.14	polymorphism	1	0.07	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4594	4594	C	T	MI.13020	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	125	42	P	L	cCa/cTa	4.4	0.99	0	probably_damaging	0.91	neutral	0.76	neutral	5.34	neutral	3.74	deleterious	-8.83	medium_impact	3.27	0.94	neutral	0.41	neutral	4.19	23.80	deleterious	0.08	0.35	0.64	disease	0.87	disease	0.71	disease	0.72	disease	4	0.89	neutral	0.43	neutral	1	deleterious	0.77	deleterious	-1.72	low_impact	0.49	medium_impact	1.61	medium_impact	0.64	0.8	NA	NA	0.52	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4596	4596	G	T	MI.13021	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	127	43	V	F	Gtt/Ttt	-16.09	0	0	benign	0.22	neutral	0.4	neutral	4.47	neutral	-2.42	neutral	-2.34	neutral_impact	0.44	0.91	neutral	0.74	neutral	3.51	23.10	deleterious	0.04	0.35	0.35	neutral	0.63	disease	0.66	disease	0.5	neutral	0	0.52	neutral	0.59	deleterious	-6	neutral	0.66	deleterious	-0.29	medium_impact	0.11	medium_impact	-0.77	medium_impact	0.30	0.8	0.29	6.93	0.31	N	0.36	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4596	4596	G	C	MI.13022	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	127	43	V	L	Gtt/Ctt	-16.09	0	0	benign	0.01	neutral	1	neutral	4.59	neutral	-0.42	neutral	-0.05	neutral_impact	-1.57	0.89	neutral	0.95	neutral	-0.82	0.04	neutral	0.18	0.45	0.2	neutral	0.16	neutral	0.35	neutral	0.21	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	1.87	high_impact	-2.47	low_impact	0.38	0.8	0.29	6.93	0.36	N	0.18	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4596	4596	G	A	MI.13023	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	127	43	V	I	Gtt/Att	-16.09	0	0	benign	0	neutral	0.36	neutral	4.94	neutral	1.41	neutral	0.57	neutral_impact	-1.18	0.97	neutral	0.95	neutral	-1.17	0.01	neutral	0.54	0.6	0.29	neutral	0.15	neutral	0.37	neutral	0.26	neutral	5	0.64	neutral	0.68	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.07	medium_impact	-2.14	low_impact	0.96	1	0.29	6.93	0.36	N	0.02	polymorphism	0.99	0.01	rs1117207	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4597	4597	T	A	MI.13024	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	128	43	V	D	gTt/gAt	-0.66	0	0	benign	0.36	neutral	0.06	neutral	4.44	deleterious	-4.28	deleterious	-5.18	low_impact	1.92	0.86	neutral	0.41	neutral	4.43	24.20	deleterious	0.01	0.35	0.78	disease	0.76	disease	0.74	disease	0.72	disease	4	0.93	neutral	0.35	neutral	-6	neutral	0.78	deleterious	-0.57	medium_impact	-0.46	medium_impact	0.47	medium_impact	0.10	0.8	0.29	6.93	0.34	N	0.66	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4597	4597	T	C	MI.13025	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	128	43	V	A	gTt/gCt	-0.66	0	0	benign	0.06	neutral	0.22	neutral	4.56	neutral	-0.77	deleterious	-3	low_impact	1.36	0.91	neutral	0.8	neutral	1.82	15.13	deleterious	0.06	0.35	0.2	neutral	0.35	neutral	0.63	disease	0.46	neutral	1	0.76	neutral	0.58	deleterious	-6	neutral	0.39	neutral	0.3	medium_impact	-0.1	medium_impact	0	medium_impact	0.23	0.8	0.29	6.93	0.47	N	0.26	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4597	4597	T	G	MI.13026	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	128	43	V	G	gTt/gGt	-0.66	0	0	benign	0.26	neutral	0.12	neutral	4.45	deleterious	-3.38	deleterious	-5.67	low_impact	1.92	0.9	neutral	0.47	neutral	3.62	23.20	deleterious	0.01	0.35	0.23	neutral	0.57	disease	0.68	disease	0.71	disease	4	0.86	neutral	0.43	neutral	-6	neutral	0.66	deleterious	-0.38	medium_impact	-0.27	medium_impact	0.47	medium_impact	0.15	0.8	0.29	6.93	0.43	N	0.57	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4599	4599	C	A	MI.13027	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	130	44	L	M	Cta/Ata	-9.18	0	0	probably_damaging	1	neutral	0.82	neutral	4.5	neutral	-1.6	neutral	-1.64	neutral_impact	-0.42	0.93	neutral	0.87	neutral	1.48	13.18	neutral	0.28	0.45	0.48	neutral	0.12	neutral	0.12	neutral	0.25	neutral	5	1	deleterious	0.41	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.57	medium_impact	-1.5	low_impact	0.54	0.8	1.15	7.68	0.34	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4599	4599	C	G	MI.13028	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	130	44	L	V	Cta/Gta	-9.18	0	0	probably_damaging	1	neutral	0.29	neutral	4.55	neutral	-0.02	neutral	-2.46	low_impact	1.74	0.87	neutral	0.17	damaging	3.27	22.80	deleterious	0.21	0.45	0.41	neutral	0.6	disease	0.55	disease	0.66	disease	3	1	deleterious	0.15	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	-0.01	medium_impact	0.32	medium_impact	0.54	0.8	1.15	7.68	0.3	N	0.39	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4600	4600	T	A	MI.13029	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	131	44	L	Q	cTa/cAa	0.26	0.01	0	probably_damaging	1	neutral	0.14	neutral	4.48	deleterious	-3.59	deleterious	-5.39	medium_impact	2.89	0.85	neutral	0.13	damaging	3.85	23.40	deleterious	0.02	0.35	0.52	disease	0.78	disease	0.56	disease	0.71	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.23	medium_impact	1.29	medium_impact	0.20	0.8	1.15	7.68	0.28	N	0.86	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9138	9138	C	G	MI.1303	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	612	204	I	M	atC/atG	4.76	0.73	0	possibly_damaging	0.59	neutral	0.29	neutral	4.12	neutral	-2.9	neutral	-1.16	low_impact	1.21	0.86	neutral	0.58	neutral	2.03	16.39	deleterious	0.5	0.65	NA	NA	0.39	neutral	0.26	neutral	0.18	neutral	6	0.72	neutral	0.35	neutral	-3	neutral	0.58	deleterious	-0.91	medium_impact	0.07	medium_impact	-0.06	medium_impact	0.56	0.9	27.88	21.96	0.42	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4600	4600	T	G	MI.13030	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	131	44	L	R	cTa/cGa	0.26	0.01	0	probably_damaging	1	neutral	0.23	neutral	4.48	deleterious	-3.24	deleterious	-5.42	medium_impact	2.89	0.77	neutral	0.1	damaging	3.96	23.60	deleterious	0.02	0.35	0.72	disease	0.91	disease	0.69	disease	0.77	disease	5	1	deleterious	0.12	neutral	1	deleterious	0.91	deleterious	-3.54	low_impact	-0.08	medium_impact	1.29	medium_impact	0.13	0.8	1.15	7.68	0.25	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4600	4600	T	C	MI.13031	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	131	44	L	P	cTa/cCa	0.26	0.01	0	probably_damaging	1	neutral	0.25	neutral	4.46	deleterious	-3.97	deleterious	-6.29	medium_impact	2.54	0.69	neutral	0.09	damaging	3.73	23.30	deleterious	0.02	0.35	0.81	disease	0.89	disease	0.7	disease	0.75	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.92	deleterious	-3.54	low_impact	-0.06	medium_impact	0.99	medium_impact	0.19	0.8	1.15	7.68	0.24	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4602	4602	A	T	MI.13032	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	133	45	T	S	Acc/Tcc	-1.58	0	0	benign	0.19	neutral	0.53	neutral	4.65	neutral	0.17	neutral	-0.69	neutral_impact	0.24	0.77	neutral	0.72	neutral	2.01	16.26	deleterious	0.32	0.5	0.44	neutral	0.08	neutral	0.19	neutral	0.32	neutral	4	0.36	neutral	0.67	deleterious	-6	neutral	0.34	neutral	-0.22	medium_impact	0.24	medium_impact	-0.94	medium_impact	0.54	0.8	0.86	7.93	0.4	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4602	4602	A	G	MI.13033	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	133	45	T	A	Acc/Gcc	-1.58	0	0	benign	0.01	neutral	0.66	neutral	4.69	neutral	0.86	neutral	-0.52	neutral_impact	0.55	0.84	neutral	0.8	neutral	1.88	15.49	deleterious	0.27	0.45	0.41	neutral	0.13	neutral	0.18	neutral	0.27	neutral	5	0.32	neutral	0.83	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.37	medium_impact	-0.68	medium_impact	0.34	0.8	0.86	7.93	0.4	N	0.32	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4602	4602	A	C	MI.13034	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	133	45	T	P	Acc/Ccc	-1.58	0	0	possibly_damaging	0.64	neutral	0.25	neutral	4.6	neutral	-1.89	neutral	-1.79	medium_impact	2.13	0.81	neutral	0.49	neutral	3.33	22.90	deleterious	0.04	0.35	0.79	disease	0.77	disease	0.68	disease	0.74	disease	5	0.77	neutral	0.31	neutral	0	NA	0.75	deleterious	-1.03	low_impact	-0.06	medium_impact	0.65	medium_impact	0.31	0.8	0.86	7.93	0.28	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4603	4603	C	A	MI.13035	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	134	45	T	N	aCc/aAc	1.18	0	0	possibly_damaging	0.64	neutral	0.37	neutral	4.61	neutral	-1.5	neutral	-1.7	low_impact	1.1	0.89	neutral	0.73	neutral	3.60	23.20	deleterious	0.24	0.45	0.73	disease	0.57	disease	0.44	neutral	0.45	neutral	1	0.69	neutral	0.37	neutral	-3	neutral	0.69	deleterious	-1.03	low_impact	0.08	medium_impact	-0.22	medium_impact	0.54	0.8	0.86	7.93	0.39	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4603	4603	C	G	MI.13036	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	134	45	T	S	aCc/aGc	1.18	0	0	benign	0.19	neutral	0.53	neutral	4.65	neutral	0.17	neutral	-0.69	neutral_impact	0.24	0.77	neutral	0.72	neutral	2.19	17.46	deleterious	0.32	0.5	0.44	neutral	0.08	neutral	0.19	neutral	0.32	neutral	4	0.36	neutral	0.67	deleterious	-6	neutral	0.34	neutral	-0.22	medium_impact	0.24	medium_impact	-0.94	medium_impact	0.54	0.8	0.86	7.93	0.42	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4603	4603	C	T	MI.13037	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	134	45	T	I	aCc/aTc	1.18	0	0	benign	0.01	neutral	0.44	neutral	4.75	neutral	1.52	neutral	1.22	low_impact	0.84	0.96	neutral	0.97	neutral	2.15	17.15	deleterious	0.14	0.4	0.3	neutral	0.48	neutral	0.26	neutral	0.38	neutral	2	0.55	neutral	0.72	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.15	medium_impact	-0.44	medium_impact	0.59	0.8	0.86	7.93	0.38	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4605	4605	A	G	MI.13038	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	136	46	K	E	Aaa/Gaa	-5.27	0	0	probably_damaging	1	neutral	0.82	neutral	4.58	neutral	-1.41	deleterious	-2.79	medium_impact	1.98	0.92	neutral	0.24	damaging	3.86	23.50	deleterious	0.15	0.4	0.36	neutral	0.84	disease	0.63	disease	0.68	disease	4	1	deleterious	0.41	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.57	medium_impact	0.52	medium_impact	0.44	0.8	8.93	9.1	0.27	N	0.65	polymorphism	1	0.05	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4605	4605	A	C	MI.13039	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	136	46	K	Q	Aaa/Caa	-5.27	0	0	probably_damaging	1	neutral	0.72	neutral	4.58	neutral	-1.65	deleterious	-2.67	low_impact	1.38	0.9	neutral	0.28	damaging	2.11	16.92	deleterious	0.3	0.45	0.22	neutral	0.59	disease	0.3	neutral	0.21	neutral	6	1	deleterious	0.36	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.44	medium_impact	0.02	medium_impact	0.29	0.8	8.93	9.1	0.23	N	0.64	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9138	9138	C	A	MI.1304	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	612	204	I	M	atC/atA	4.76	0.73	0	possibly_damaging	0.59	neutral	0.29	neutral	4.12	neutral	-2.9	neutral	-1.16	low_impact	1.21	0.86	neutral	0.58	neutral	2.51	19.51	deleterious	0.5	0.65	NA	NA	0.39	neutral	0.26	neutral	0.18	neutral	6	0.72	neutral	0.35	neutral	-3	neutral	0.58	deleterious	-0.91	medium_impact	0.07	medium_impact	-0.06	medium_impact	0.56	0.9	27.88	21.96	0.42	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4606	4606	A	C	MI.13040	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	137	46	K	T	aAa/aCa	0.72	0	0	probably_damaging	1	neutral	0.7	neutral	4.62	neutral	-0.34	deleterious	-4.1	medium_impact	2.18	0.92	neutral	0.29	neutral	3.37	22.90	deleterious	0.11	0.4	0.48	neutral	0.76	disease	0.39	neutral	0.22	neutral	6	1	deleterious	0.35	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.41	medium_impact	0.69	medium_impact	0.25	0.8	8.93	9.1	0.26	N	0.61	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4606	4606	A	T	MI.13041	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	137	46	K	M	aAa/aTa	0.72	0	0	probably_damaging	1	neutral	0.26	neutral	4.58	neutral	-1.37	deleterious	-4.01	medium_impact	2.08	0.94	neutral	0.24	damaging	3.80	23.40	deleterious	0.11	0.4	0.74	disease	0.77	disease	0.49	neutral	0.42	neutral	2	1	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.04	medium_impact	0.61	medium_impact	0.17	0.8	8.93	9.1	0.4	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4607	4607	A	C	MI.13042	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	138	46	K	N	aaA/aaC	1.87	0	0	probably_damaging	1	neutral	0.61	neutral	4.59	neutral	-1.02	deleterious	-2.94	low_impact	1.47	0.91	neutral	0.75	neutral	2.24	17.80	deleterious	0.39	0.5	0.24	neutral	0.75	disease	0.36	neutral	0.22	neutral	6	1	deleterious	0.31	neutral	-2	neutral	0.77	deleterious	-3.54	low_impact	0.32	medium_impact	0.09	medium_impact	0.35	0.8	8.93	9.1	0.27	N	0.34	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4607	4607	A	T	MI.13043	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	138	46	K	N	aaA/aaT	1.87	0	0	probably_damaging	1	neutral	0.61	neutral	4.59	neutral	-1.02	deleterious	-2.94	low_impact	1.47	0.91	neutral	0.75	neutral	2.32	18.30	deleterious	0.39	0.5	0.24	neutral	0.75	disease	0.36	neutral	0.22	neutral	6	1	deleterious	0.31	neutral	-2	neutral	0.77	deleterious	-3.54	low_impact	0.32	medium_impact	0.09	medium_impact	0.35	0.8	8.93	9.1	0.27	N	0.34	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4608	4608	A	C	MI.13044	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	139	47	K	Q	Aaa/Caa	0.03	0	0	probably_damaging	0.9	neutral	0.35	neutral	4.63	neutral	-1.44	neutral	-1.83	low_impact	0.89	0.87	neutral	0.79	neutral	1.59	13.80	neutral	0.37	0.5	0.58	disease	0.25	neutral	0.22	neutral	0.55	disease	1	0.91	neutral	0.23	neutral	-2	neutral	0.69	deleterious	-1.67	low_impact	0.06	medium_impact	-0.4	medium_impact	0.23	0.8	0.86	8.89	0.43	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4608	4608	A	G	MI.13045	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	139	47	K	E	Aaa/Gaa	0.03	0	0	possibly_damaging	0.64	neutral	0.34	neutral	4.61	neutral	-1.1	neutral	-2.04	low_impact	1.59	0.9	neutral	0.5	neutral	2.35	18.47	deleterious	0.2	0.45	0.55	disease	0.63	disease	0.45	neutral	0.46	neutral	1	0.71	neutral	0.35	neutral	-3	neutral	0.68	deleterious	-1.03	low_impact	0.05	medium_impact	0.19	medium_impact	0.40	0.8	0.86	8.89	0.43	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4609	4609	A	T	MI.13046	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	140	47	K	M	aAa/aTa	0.26	0	0	probably_damaging	0.98	neutral	0.25	neutral	4.55	deleterious	-3.96	deleterious	-3.82	low_impact	1.7	0.86	neutral	0.29	neutral	3.46	23.00	deleterious	0.17	0.45	0.87	disease	0.32	neutral	0.28	neutral	0.65	disease	3	0.98	deleterious	0.14	neutral	-2	neutral	0.76	deleterious	-2.34	low_impact	-0.06	medium_impact	0.29	medium_impact	0.17	0.8	0.86	8.89	0.37	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4609	4609	A	C	MI.13047	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	140	47	K	T	aAa/aCa	0.26	0	0	possibly_damaging	0.67	neutral	0.44	neutral	4.57	neutral	-1.91	deleterious	-3.24	low_impact	0.88	0.87	neutral	0.9	neutral	2.00	16.21	deleterious	0.2	0.45	0.69	disease	0.33	neutral	0.29	neutral	0.62	disease	2	0.67	neutral	0.39	neutral	-3	neutral	0.66	deleterious	-1.08	low_impact	0.15	medium_impact	-0.4	medium_impact	0.15	0.8	0.86	8.89	0.37	N	0.72	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4610	4610	A	T	MI.13048	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	141	47	K	N	aaA/aaT	0.95	0	0	benign	0.06	neutral	0.39	neutral	4.62	neutral	-1.32	neutral	-1.5	neutral_impact	0.64	0.88	neutral	0.88	neutral	2.01	16.25	deleterious	0.58	0.65	0.43	neutral	0.39	neutral	0.26	neutral	0.46	neutral	1	0.57	neutral	0.67	deleterious	-6	neutral	0.21	neutral	0.3	medium_impact	0.1	medium_impact	-0.61	medium_impact	0.28	0.8	0.86	8.89	0.42	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4610	4610	A	C	MI.13049	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	141	47	K	N	aaA/aaC	0.95	0	0	benign	0.06	neutral	0.39	neutral	4.62	neutral	-1.32	neutral	-1.5	neutral_impact	0.64	0.88	neutral	0.88	neutral	1.95	15.88	deleterious	0.58	0.65	0.43	neutral	0.39	neutral	0.26	neutral	0.46	neutral	1	0.57	neutral	0.67	deleterious	-6	neutral	0.21	neutral	0.3	medium_impact	0.1	medium_impact	-0.61	medium_impact	0.28	0.8	0.86	8.89	0.41	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9139	9139	G	C	MI.1305	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	613	205	A	P	Gct/Cct	-7.28	0	0	probably_damaging	1	neutral	0.05	neutral	4.22	deleterious	-3.67	deleterious	-4.16	high_impact	4.25	0.46	damaging	0.44	neutral	3.89	23.50	deleterious	0.14	0.65	NA	NA	0.94	disease	0.72	disease	0.86	disease	7	1	deleterious	0.03	neutral	2	deleterious	0.94	deleterious	-3.6	low_impact	-0.43	medium_impact	2.54	high_impact	0.77	0.9	15.93	18.3	0.49	N	0.97	disease_causing	0.93	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4611	4611	A	T	MI.13050	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	142	48	M	L	Ata/Tta	-7.8	0	0	benign	0.02	neutral	0.65	neutral	4.66	neutral	1.32	neutral	-0.54	neutral_impact	0.2	0.91	neutral	0.6	neutral	-0.08	1.87	neutral	0.39	0.5	0.31	neutral	0.48	neutral	0.45	neutral	0.44	neutral	1	0.31	neutral	0.82	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	0.36	medium_impact	-0.98	medium_impact	0.25	0.8	18.44	10.65	0.33	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4611	4611	A	G	MI.13051	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	142	48	M	V	Ata/Gta	-7.8	0	0	benign	0.04	neutral	0.49	neutral	4.69	neutral	1	neutral	-0.44	neutral_impact	0.3	0.85	neutral	0.67	neutral	-0.58	0.14	neutral	0.38	0.5	0.32	neutral	0.57	disease	0.47	neutral	0.47	neutral	1	0.47	neutral	0.73	deleterious	-6	neutral	0.22	neutral	0.47	medium_impact	0.2	medium_impact	-0.89	medium_impact	0.30	0.8	18.44	10.65	0.25	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4611	4611	A	C	MI.13052	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	142	48	M	L	Ata/Cta	-7.8	0	0	benign	0.02	neutral	0.65	neutral	4.66	neutral	1.32	neutral	-0.54	neutral_impact	0.2	0.91	neutral	0.6	neutral	-0.16	1.34	neutral	0.39	0.5	0.31	neutral	0.48	neutral	0.45	neutral	0.44	neutral	1	0.31	neutral	0.82	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	0.36	medium_impact	-0.98	medium_impact	0.25	0.8	18.44	10.65	0.33	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4612	4612	T	A	MI.13053	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	143	48	M	K	aTa/aAa	-1.12	0	0.01	benign	0.12	neutral	0.55	neutral	4.84	neutral	3.11	neutral	-0.41	neutral_impact	-1.63	0.91	neutral	0.87	neutral	0.66	8.59	deleterious	0.16	0.45	0.37	neutral	0.75	disease	0.51	disease	0.43	neutral	1	0.36	neutral	0.72	deleterious	-6	neutral	0.33	neutral	-0.01	medium_impact	0.26	medium_impact	-2.52	low_impact	0.17	0.8	18.44	10.65	0.28	N	0.33	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4612	4612	T	C	MI.13054	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	143	48	M	T	aTa/aCa	-1.12	0	0.01	benign	0	neutral	0.45	neutral	4.75	neutral	2.2	neutral	-0.01	neutral_impact	-0.22	0.97	neutral	0.92	neutral	-0.49	0.23	neutral	0.22	0.45	0.38	neutral	0.49	neutral	0.39	neutral	0.24	neutral	5	0.55	neutral	0.73	deleterious	-6	neutral	0.21	neutral	1.95	medium_impact	0.16	medium_impact	-1.33	low_impact	0.11	0.8	18.44	10.65	0.33	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4613	4613	A	T	MI.13055	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	144	48	M	I	atA/atT	0.03	0	0	benign	0.08	neutral	0.51	neutral	4.67	neutral	0.63	neutral	-0.59	neutral_impact	0.12	0.89	neutral	0.63	neutral	0.16	4.27	deleterious	0.32	0.5	0.32	neutral	0.54	disease	0.46	neutral	0.47	neutral	1	0.42	neutral	0.72	deleterious	-6	neutral	0.34	neutral	0.17	medium_impact	0.22	medium_impact	-1.04	low_impact	0.36	0.8	18.44	10.65	0.32	N	0.23	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4613	4613	A	C	MI.13056	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	144	48	M	I	atA/atC	0.03	0	0	benign	0.08	neutral	0.51	neutral	4.67	neutral	0.63	neutral	-0.59	neutral_impact	0.12	0.89	neutral	0.63	neutral	0.08	3.43	deleterious	0.32	0.5	0.32	neutral	0.54	disease	0.46	neutral	0.47	neutral	1	0.42	neutral	0.72	deleterious	-6	neutral	0.34	neutral	0.17	medium_impact	0.22	medium_impact	-1.04	low_impact	0.36	0.8	18.44	10.65	0.32	N	0.23	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4614	4614	A	C	MI.13057	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	145	49	N	H	Aac/Cac	-3.19	0	0	possibly_damaging	0.69	neutral	0.93	neutral	4.59	neutral	-1.46	deleterious	-3.69	neutral_impact	-0.11	0.86	neutral	0.94	neutral	1.03	10.83	neutral	0.76	0.8	0.48	neutral	0.06	neutral	0.33	neutral	0.2	neutral	6	0.66	neutral	0.62	deleterious	-3	neutral	0.67	deleterious	-1.12	low_impact	0.83	medium_impact	-1.24	low_impact	0.19	0.8	NA	NA	0.3	N	0.06	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4614	4614	A	T	MI.13058	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	145	49	N	Y	Aac/Tac	-3.19	0	0	possibly_damaging	0.6	neutral	1	neutral	4.6	neutral	-1.4	deleterious	-5.88	medium_impact	1.98	0.86	neutral	0.49	neutral	3.49	23.10	deleterious	0.23	0.45	0.87	disease	0.71	disease	0.7	disease	0.7	disease	4	0.6	neutral	0.7	deleterious	0	NA	0.84	deleterious	-0.96	medium_impact	1.87	high_impact	0.52	medium_impact	0.21	0.8	NA	NA	0.18	N	0.60	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4614	4614	A	G	MI.13059	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	145	49	N	D	Aac/Gac	-3.19	0	0	benign	0.13	neutral	0.33	neutral	4.65	neutral	0.18	deleterious	-3.5	medium_impact	2.27	0.85	neutral	0.4	neutral	1.99	16.13	deleterious	0.77	0.8	0.23	neutral	0.65	disease	0.69	disease	0.7	disease	4	0.62	neutral	0.6	deleterious	-3	neutral	0.58	deleterious	-0.04	medium_impact	0.04	medium_impact	0.77	medium_impact	0.33	0.8	NA	NA	0.34	N	0.42	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9139	9139	G	A	MI.1306	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	613	205	A	T	Gct/Act	-7.28	0	0	probably_damaging	1	neutral	0.06	neutral	4.26	neutral	-1.76	deleterious	-2.95	high_impact	3.7	0.74	neutral	0.55	neutral	4.25	23.90	deleterious	0.37	0.65	NA	NA	0.87	disease	0.6	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.38	medium_impact	2.07	high_impact	0.66	0.9	15.93	18.3	0.43	N	0.80	disease_causing	0.79	0.22	rs879243938	.	.	.	.	.	.	CPD	0.15	G9139A	LHON	+	-	Reported - possibly synergistic	1	N	N	N	damaging
chrM	4615	4615	A	T	MI.13060	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	146	49	N	I	aAc/aTc	0.95	0	0	possibly_damaging	0.52	neutral	0.54	neutral	4.59	neutral	-1.96	deleterious	-6.5	medium_impact	2.38	0.87	neutral	0.48	neutral	3.48	23.10	deleterious	0.21	0.45	0.85	disease	0.73	disease	0.65	disease	0.7	disease	4	0.49	neutral	0.51	deleterious	0	NA	0.82	deleterious	-0.83	medium_impact	0.25	medium_impact	0.86	medium_impact	0.13	0.8	NA	NA	0.28	N	0.67	polymorphism	1	0.08	rs386828946	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4615	4615	A	G	MI.13061	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	146	49	N	S	aAc/aGc	0.95	0	0	benign	0	neutral	0.76	neutral	4.83	neutral	1.87	deleterious	-2.55	neutral_impact	0.58	0.95	neutral	0.99	neutral	-0.52	0.19	neutral	0.7	0.75	0.47	neutral	0.5	neutral	0.45	neutral	0.24	neutral	5	0.23	neutral	0.88	deleterious	-6	neutral	0.24	neutral	1.95	medium_impact	0.49	medium_impact	-0.66	medium_impact	0.38	0.8	NA	NA	0.33	N	0.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4615	4615	A	C	MI.13062	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	146	49	N	T	aAc/aCc	0.95	0	0	benign	0.13	neutral	0.52	neutral	4.64	neutral	-0.02	deleterious	-3.52	low_impact	1.06	0.89	neutral	0.76	neutral	0.34	6.11	deleterious	0.56	0.6	0.67	disease	0.51	disease	0.43	neutral	0.3	neutral	4	0.39	neutral	0.7	deleterious	-6	neutral	0.62	deleterious	-0.04	medium_impact	0.23	medium_impact	-0.25	medium_impact	0.34	0.8	NA	NA	0.36	N	0.04	polymorphism	1	0.06	rs386828946	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4616	4616	C	A	MI.13063	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	147	49	N	K	aaC/aaA	0.72	0	0	benign	0.01	neutral	0.62	neutral	4.79	neutral	1.58	deleterious	-4.11	low_impact	1.66	0.86	neutral	0.58	neutral	2.59	20.10	deleterious	0.64	0.7	0.57	disease	0.71	disease	0.7	disease	0.72	disease	4	0.36	neutral	0.81	deleterious	-6	neutral	0.34	neutral	1.03	medium_impact	0.33	medium_impact	0.25	medium_impact	0.46	0.8	NA	NA	0.27	N	0.40	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4616	4616	C	G	MI.13064	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	147	49	N	K	aaC/aaG	0.72	0	0	benign	0.01	neutral	0.62	neutral	4.79	neutral	1.58	deleterious	-4.11	low_impact	1.66	0.86	neutral	0.58	neutral	2.15	17.20	deleterious	0.64	0.7	0.57	disease	0.71	disease	0.7	disease	0.72	disease	4	0.36	neutral	0.81	deleterious	-6	neutral	0.34	neutral	1.03	medium_impact	0.33	medium_impact	0.25	medium_impact	0.46	0.8	NA	NA	0.27	N	0.40	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4617	4617	C	A	MI.13065	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	148	50	P	T	Cct/Act	-0.2	0	0	benign	0.05	neutral	0.57	neutral	4.56	neutral	-1.23	deleterious	-7.28	medium_impact	2.27	0.79	neutral	0.54	neutral	3.71	23.30	deleterious	0.36	0.5	0.43	neutral	0.84	disease	0.6	disease	0.69	disease	4	0.38	neutral	0.76	deleterious	-3	neutral	0.31	neutral	0.37	medium_impact	0.28	medium_impact	0.77	medium_impact	0.41	0.8	NA	NA	0.24	N	0.40	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4617	4617	C	T	MI.13066	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	148	50	P	S	Cct/Tct	-0.2	0	0	benign	0.03	neutral	0.89	neutral	4.62	neutral	-0.79	deleterious	-7.26	medium_impact	2	0.86	neutral	0.66	neutral	3.65	23.20	deleterious	0.4	0.5	0.4	neutral	0.85	disease	0.59	disease	0.57	disease	1	0.05	neutral	0.93	deleterious	-3	neutral	0.31	neutral	0.59	medium_impact	0.71	medium_impact	0.54	medium_impact	0.28	0.8	NA	NA	0.25	N	0.68	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4617	4617	C	G	MI.13067	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	148	50	P	A	Cct/Gct	-0.2	0	0	benign	0.02	neutral	0.76	neutral	4.59	neutral	-0.13	deleterious	-7.28	medium_impact	3.04	0.82	neutral	0.65	neutral	2.93	22.00	deleterious	0.43	0.55	0.38	neutral	0.67	disease	0.67	disease	0.66	disease	3	0.2	neutral	0.87	deleterious	-3	neutral	0.24	neutral	0.75	medium_impact	0.49	medium_impact	1.42	medium_impact	0.59	0.8	NA	NA	0.27	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4618	4618	C	A	MI.13068	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	149	50	P	H	cCt/cAt	3.48	0.99	0	probably_damaging	0.93	neutral	0.43	neutral	4.51	neutral	-2.35	deleterious	-8.23	medium_impact	3.15	0.81	neutral	0.35	neutral	3.78	23.40	deleterious	0.18	0.45	0.66	disease	0.84	disease	0.72	disease	0.72	disease	4	0.93	neutral	0.25	neutral	1	deleterious	0.82	deleterious	-1.83	low_impact	0.14	medium_impact	1.51	medium_impact	0.21	0.8	NA	NA	0.48	N	0.91	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4618	4618	C	T	MI.13069	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	149	50	P	L	cCt/cTt	3.48	0.99	0	benign	0.03	neutral	0.78	neutral	4.6	neutral	-1.03	deleterious	-9.12	medium_impact	2.02	0.79	neutral	0.43	neutral	4.17	23.80	deleterious	0.25	0.45	0.3	neutral	0.86	disease	0.65	disease	0.71	disease	4	0.16	neutral	0.88	deleterious	-3	neutral	0.26	neutral	0.59	medium_impact	0.51	medium_impact	0.56	medium_impact	0.65	0.8	NA	NA	0.42	N	0.50	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9139	9139	G	T	MI.1307	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	613	205	A	S	Gct/Tct	-7.28	0	0	probably_damaging	0.99	neutral	0.13	neutral	4.26	neutral	-2.07	neutral	-2.32	medium_impact	2.75	0.59	damaging	0.58	neutral	3.79	23.40	deleterious	0.32	0.65	NA	NA	0.89	disease	0.59	disease	0.67	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.91	deleterious	-2.65	low_impact	-0.18	medium_impact	1.26	medium_impact	0.62	0.9	15.93	18.3	0.33	N	0.95	disease_causing	0.63	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4618	4618	C	G	MI.13070	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	149	50	P	R	cCt/cGt	3.48	0.99	0	possibly_damaging	0.76	neutral	0.5	neutral	4.54	neutral	-0.49	deleterious	-8.23	medium_impact	2.81	0.83	neutral	0.37	neutral	3.47	23.00	deleterious	0.12	0.4	0.53	disease	0.89	disease	0.73	disease	0.73	disease	5	0.74	neutral	0.37	neutral	0	NA	0.78	deleterious	-1.26	low_impact	0.21	medium_impact	1.22	medium_impact	0.27	0.8	NA	NA	0.48	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4620	4620	C	T	MI.13071	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	151	51	R	C	Cgt/Tgt	-8.95	0	0	probably_damaging	1	neutral	0.16	neutral	4.46	deleterious	-5.77	deleterious	-7.46	high_impact	3.86	0.75	neutral	0.05	damaging	4.92	25.00	deleterious	0.08	0.35	0.74	disease	0.88	disease	0.76	disease	0.72	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.19	medium_impact	2.11	high_impact	0.82	0.85	NA	NA	0.33	N	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4620	4620	C	A	MI.13072	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	151	51	R	S	Cgt/Agt	-8.95	0	0	probably_damaging	1	neutral	0.7	neutral	4.58	neutral	-1.56	deleterious	-5.6	medium_impact	2.12	0.88	neutral	0.1	damaging	4.52	24.30	deleterious	0.1	0.4	0.48	neutral	0.89	disease	0.71	disease	0.72	disease	4	1	deleterious	0.35	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.41	medium_impact	0.64	medium_impact	0.26	0.8	NA	NA	0.23	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4620	4620	C	G	MI.13073	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	151	51	R	G	Cgt/Ggt	-8.95	0	0	probably_damaging	1	neutral	0.35	neutral	4.49	neutral	-2.22	deleterious	-6.53	medium_impact	2.82	0.76	neutral	0.09	damaging	4.12	23.80	deleterious	0.09	0.35	0.64	disease	0.84	disease	0.73	disease	0.72	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.06	medium_impact	1.23	medium_impact	0.16	0.8	NA	NA	0.24	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4621	4621	G	A	MI.13074	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	152	51	R	H	cGt/cAt	2.79	0.98	0	probably_damaging	1	neutral	0.52	neutral	4.49	deleterious	-3.19	deleterious	-4.66	medium_impact	3.31	0.74	neutral	0.05	damaging	4.26	23.90	deleterious	0.26	0.45	0.69	disease	0.83	disease	0.72	disease	0.7	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	0.23	medium_impact	1.64	medium_impact	0.91	0.95	NA	NA	0.48	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4621	4621	G	C	MI.13075	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	152	51	R	P	cGt/cCt	2.79	0.98	0	probably_damaging	1	neutral	0.26	neutral	4.48	deleterious	-3.41	deleterious	-6.53	medium_impact	2.96	0.76	neutral	0.06	damaging	4.07	23.70	deleterious	0.04	0.35	0.71	disease	0.9	disease	0.81	disease	0.74	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.88	deleterious	-3.54	low_impact	-0.04	medium_impact	1.35	medium_impact	0.11	0.8	NA	NA	0.49	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4621	4621	G	T	MI.13076	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	152	51	R	L	cGt/cTt	2.79	0.98	0	probably_damaging	1	neutral	0.73	neutral	4.51	neutral	-1.86	deleterious	-6.53	low_impact	1.93	0.7	neutral	0.06	damaging	4.19	23.80	deleterious	0.1	0.4	0.37	neutral	0.92	disease	0.72	disease	0.72	disease	4	1	deleterious	0.37	neutral	-2	neutral	0.83	deleterious	-3.54	low_impact	0.45	medium_impact	0.48	medium_impact	0.05	0.8	NA	NA	0.4	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4623	4623	T	G	MI.13077	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	154	52	S	A	Tcc/Gcc	-0.43	0.01	0	probably_damaging	1	neutral	0.94	neutral	4.59	neutral	-1.14	neutral	-1.5	neutral_impact	-0.38	0.9	neutral	0.97	neutral	1.54	13.50	neutral	0.35	0.5	0.41	neutral	0.07	neutral	0.21	neutral	0.34	neutral	3	0.99	deleterious	0.47	deleterious	-2	neutral	0.70	deleterious	-3.54	low_impact	0.87	medium_impact	-1.46	low_impact	0.39	0.8	0.86	6.84	0.35	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4623	4623	T	C	MI.13078	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	154	52	S	P	Tcc/Ccc	-0.43	0.01	0	probably_damaging	1	neutral	0.22	neutral	4.37	deleterious	-4.41	deleterious	-3.97	medium_impact	2.18	0.76	neutral	0.18	damaging	3.81	23.40	deleterious	0.06	0.35	0.87	disease	0.92	disease	0.63	disease	0.7	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.93	deleterious	-3.54	low_impact	-0.1	medium_impact	0.69	medium_impact	0.15	0.8	0.86	6.84	0.28	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4623	4623	T	A	MI.13079	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	154	52	S	T	Tcc/Acc	-0.43	0.01	0	probably_damaging	1	neutral	0.38	neutral	4.42	neutral	-2.76	neutral	-2.21	low_impact	1.27	0.91	neutral	0.8	neutral	2.54	19.71	deleterious	0.32	0.5	0.7	disease	0.56	disease	0.48	neutral	0.34	neutral	3	1	deleterious	0.19	neutral	-2	neutral	0.82	deleterious	-3.54	low_impact	0.09	medium_impact	-0.08	medium_impact	0.50	0.8	0.86	6.84	0.39	N	0.47	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9140	9140	C	T	MI.1308	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	614	205	A	V	gCt/gTt	6.14	1	0	probably_damaging	1	neutral	0.09	neutral	4.3	neutral	-0.55	deleterious	-3.3	medium_impact	3.28	0.47	damaging	0.44	neutral	4.53	24.30	deleterious	0.35	0.65	NA	NA	0.92	disease	0.58	disease	0.72	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.92	deleterious	-3.6	low_impact	-0.28	medium_impact	1.71	medium_impact	0.64	0.9	15.93	18.3	0.66	P	0.75	disease_causing	1	0.09	rs878972895	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4624	4624	C	A	MI.13080	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	155	52	S	Y	tCc/tAc	0.49	0.11	0	probably_damaging	1	neutral	1	neutral	4.36	deleterious	-4.8	deleterious	-4.9	medium_impact	2.35	0.86	neutral	0.13	damaging	3.88	23.50	deleterious	0.07	0.35	0.93	disease	0.84	disease	0.65	disease	0.72	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.91	deleterious	-3.54	low_impact	1.87	high_impact	0.83	medium_impact	0.13	0.8	0.86	6.84	0.21	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4624	4624	C	G	MI.13081	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	155	52	S	C	tCc/tGc	0.49	0.11	0	probably_damaging	1	neutral	0.17	neutral	4.35	deleterious	-6.34	deleterious	-3.76	medium_impact	2.6	0.77	neutral	0.12	damaging	3.44	23.00	deleterious	0.08	0.35	0.92	disease	0.8	disease	0.6	disease	0.7	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.88	deleterious	-3.54	low_impact	-0.17	medium_impact	1.04	medium_impact	0.24	0.8	0.86	6.84	0.3	N	0.57	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4624	4624	C	T	MI.13082	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	155	52	S	F	tCc/tTc	0.49	0.11	0	probably_damaging	1	neutral	0.66	neutral	4.36	deleterious	-5.52	deleterious	-4.9	medium_impact	2.35	0.79	neutral	0.11	damaging	4.12	23.80	deleterious	0.08	0.35	0.93	disease	0.86	disease	0.65	disease	0.69	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.91	deleterious	-3.54	low_impact	0.37	medium_impact	0.83	medium_impact	0.03	0.8	0.86	6.84	0.22	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4626	4626	A	T	MI.13083	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	157	53	T	S	Aca/Tca	-5.27	0	0	possibly_damaging	0.79	neutral	0.91	neutral	4.63	neutral	-0.18	neutral	-2.32	low_impact	1	0.88	neutral	0.56	neutral	3.24	22.80	deleterious	0.34	0.5	0.51	disease	0.6	disease	0.51	disease	0.5	disease	0	0.77	neutral	0.56	deleterious	-3	neutral	0.72	deleterious	-1.32	low_impact	0.77	medium_impact	-0.3	medium_impact	0.43	0.8	NA	NA	0.28	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4626	4626	A	C	MI.13084	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	157	53	T	P	Aca/Cca	-5.27	0	0	probably_damaging	0.98	neutral	0.24	neutral	4.54	neutral	-2.9	deleterious	-3.8	medium_impact	2.29	0.78	neutral	0.32	neutral	3.35	22.90	deleterious	0.03	0.35	0.79	disease	0.86	disease	0.66	disease	0.73	disease	5	0.98	deleterious	0.13	neutral	1	deleterious	0.87	deleterious	-2.34	low_impact	-0.07	medium_impact	0.78	medium_impact	0.17	0.8	NA	NA	0.26	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4626	4626	A	G	MI.13085	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	157	53	T	A	Aca/Gca	-5.27	0	0	benign	0.16	neutral	0.68	neutral	4.65	neutral	0.13	deleterious	-2.73	low_impact	1.59	0.92	neutral	0.81	neutral	3.30	22.90	deleterious	0.24	0.45	0.47	neutral	0.43	neutral	0.52	disease	0.47	neutral	1	0.2	neutral	0.76	deleterious	-6	neutral	0.29	neutral	-0.14	medium_impact	0.39	medium_impact	0.19	medium_impact	0.31	0.8	NA	NA	0.27	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4627	4627	C	A	MI.13086	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	158	53	T	K	aCa/aAa	1.41	0	0	probably_damaging	0.94	neutral	0.57	neutral	4.58	neutral	-1.06	deleterious	-3.54	medium_impact	2.04	0.85	neutral	0.39	neutral	4.33	24.00	deleterious	0.06	0.35	0.71	disease	0.82	disease	0.66	disease	0.72	disease	4	0.93	neutral	0.32	neutral	1	deleterious	0.83	deleterious	-1.89	low_impact	0.28	medium_impact	0.57	medium_impact	0.26	0.8	NA	NA	0.21	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4627	4627	C	T	MI.13087	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	158	53	T	M	aCa/aTa	1.41	0	0	probably_damaging	0.99	neutral	0.37	neutral	4.6	neutral	-0.68	neutral	-1.51	low_impact	1.76	0.91	neutral	0.95	neutral	2.45	19.15	deleterious	0.1	0.4	0.19	neutral	0.51	disease	0.28	neutral	0.23	neutral	5	0.99	deleterious	0.19	neutral	-2	neutral	0.68	deleterious	-2.62	low_impact	0.08	medium_impact	0.34	medium_impact	0.52	0.8	NA	NA	0.39	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4629	4629	G	C	MI.13088	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	160	54	E	Q	Gaa/Caa	-1.81	0	0	probably_damaging	1	neutral	0.31	neutral	4.46	deleterious	-3.38	deleterious	-2.8	medium_impact	3.04	0.86	neutral	0.13	damaging	3.20	22.70	deleterious	0.13	0.4	0.71	disease	0.85	disease	0.56	disease	0.67	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	0.02	medium_impact	1.42	medium_impact	0.57	0.8	NA	NA	0.3	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4629	4629	G	A	MI.13089	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	160	54	E	K	Gaa/Aaa	-1.81	0	0	probably_damaging	1	neutral	0.44	neutral	4.53	neutral	-2.49	deleterious	-3.73	medium_impact	3.11	0.87	neutral	0.11	damaging	4.31	24.00	deleterious	0.05	0.35	0.65	disease	0.91	disease	0.67	disease	0.72	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	0.15	medium_impact	1.47	medium_impact	0.80	0.85	NA	NA	0.36	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9140	9140	C	A	MI.1309	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	614	205	A	D	gCt/gAt	6.14	1	0	probably_damaging	1	deleterious	0.03	neutral	4.22	deleterious	-4.22	deleterious	-4.89	high_impact	4.25	0.63	neutral	0.45	neutral	4.58	24.40	deleterious	0.15	0.65	NA	NA	0.96	disease	0.72	disease	0.86	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.94	deleterious	-3.6	low_impact	-0.56	medium_impact	2.54	high_impact	0.55	0.9	15.93	18.3	0.51	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4630	4630	A	T	MI.13090	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	161	54	E	V	gAa/gTa	5.09	1	0	probably_damaging	1	neutral	0.52	neutral	4.38	deleterious	-4.37	deleterious	-6.53	high_impact	3.54	0.77	neutral	0.12	damaging	3.93	23.50	deleterious	0.02	0.35	0.53	disease	0.9	disease	0.65	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.23	medium_impact	1.84	medium_impact	0.22	0.8	NA	NA	0.51	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4630	4630	A	C	MI.13091	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	161	54	E	A	gAa/gCa	5.09	1	0	probably_damaging	1	neutral	0.6	neutral	4.46	deleterious	-3.2	deleterious	-5.6	high_impact	4.08	0.89	neutral	0.15	damaging	3.45	23.00	deleterious	0.04	0.35	0.59	disease	0.75	disease	0.62	disease	0.66	disease	3	1	deleterious	0.3	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.31	medium_impact	2.29	high_impact	0.29	0.8	NA	NA	0.55	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4630	4630	A	G	MI.13092	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	161	54	E	G	gAa/gGa	5.09	1	0	probably_damaging	1	neutral	0.3	neutral	4.38	deleterious	-4.32	deleterious	-6.53	high_impact	3.74	0.83	neutral	0.15	damaging	4.06	23.70	deleterious	0.04	0.35	0.78	disease	0.85	disease	0.65	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0	medium_impact	2	high_impact	0.22	0.8	NA	NA	0.57	P	0.45	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4631	4631	A	T	MI.13093	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	162	54	E	D	gaA/gaT	8.55	1	0	probably_damaging	1	neutral	0.26	neutral	4.41	deleterious	-3.41	deleterious	-2.8	medium_impact	3.04	0.84	neutral	0.11	damaging	3.73	23.30	deleterious	0.17	0.45	0.76	disease	0.81	disease	0.51	disease	0.66	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.04	medium_impact	1.42	medium_impact	0.55	0.8	NA	NA	0.56	P	0.85	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4631	4631	A	C	MI.13094	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	162	54	E	D	gaA/gaC	8.55	1	0	probably_damaging	1	neutral	0.26	neutral	4.41	deleterious	-3.41	deleterious	-2.8	medium_impact	3.04	0.84	neutral	0.11	damaging	3.59	23.20	deleterious	0.17	0.45	0.76	disease	0.81	disease	0.51	disease	0.66	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.04	medium_impact	1.42	medium_impact	0.55	0.8	NA	NA	0.55	P	0.85	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4632	4632	G	C	MI.13095	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	163	55	A	P	Gct/Cct	3.25	1	0	probably_damaging	1	neutral	0.1	neutral	4.2	deleterious	-6.22	deleterious	-4.66	medium_impact	2.9	0.94	neutral	0.44	neutral	3.69	23.30	deleterious	0.02	0.35	0.91	disease	0.92	disease	0.74	disease	0.68	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.93	deleterious	-3.54	low_impact	-0.32	medium_impact	1.3	medium_impact	0.36	0.8	0.58	7.14	0.59	P	0.94	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4632	4632	G	A	MI.13096	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	163	55	A	T	Gct/Act	3.25	1	0	probably_damaging	1	neutral	0.19	neutral	4.21	deleterious	-4.91	deleterious	-3.73	medium_impact	2.4	0.87	neutral	0.39	neutral	4.14	23.80	deleterious	0.04	0.35	0.81	disease	0.88	disease	0.62	disease	0.68	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.90	deleterious	-3.54	low_impact	-0.14	medium_impact	0.88	medium_impact	0.68	0.85	0.58	7.14	0.54	N	0.71	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4632	4632	G	T	MI.13097	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	163	55	A	S	Gct/Tct	3.25	1	0	probably_damaging	1	neutral	0.51	neutral	4.36	deleterious	-3.59	deleterious	-2.8	low_impact	1.08	0.86	neutral	0.75	neutral	2.35	18.50	deleterious	0.07	0.35	0.78	disease	0.8	disease	0.27	neutral	0.27	neutral	5	1	deleterious	0.26	neutral	-2	neutral	0.89	deleterious	-3.54	low_impact	0.22	medium_impact	-0.24	medium_impact	0.44	0.8	0.58	7.14	0.4	N	0.39	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4633	4633	C	G	MI.13098	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	164	55	A	G	gCt/gGt	4.17	1	0	probably_damaging	1	neutral	0.15	neutral	4.23	deleterious	-3.93	deleterious	-3.73	medium_impact	2.45	0.95	neutral	0.58	neutral	3.81	23.40	deleterious	0.04	0.35	0.85	disease	0.86	disease	0.49	neutral	0.64	disease	3	1	deleterious	0.08	neutral	1	deleterious	0.88	deleterious	-3.54	low_impact	-0.21	medium_impact	0.92	medium_impact	0.55	0.8	0.58	7.14	0.68	P	0.60	polymorphism	1	0.06	.	.	.	.	.	.	.	.	0.3	C4633G	LHON candidate	+	-	Reported	1	.	P	P	damaging
chrM	4633	4633	C	A	MI.13099	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	164	55	A	D	gCt/gAt	4.17	1	0	probably_damaging	1	neutral	0.09	neutral	4.2	deleterious	-5.86	deleterious	-5.6	high_impact	3.87	0.85	neutral	0.4	neutral	4.40	24.10	deleterious	0.02	0.35	0.93	disease	0.94	disease	0.73	disease	0.67	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.92	deleterious	-3.54	low_impact	-0.35	medium_impact	2.11	high_impact	0.30	0.8	0.58	7.14	0.62	P	0.96	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8587	8587	G	C	MI.131	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	61	21	V	L	Gta/Cta	-8.2	0	0	benign	0.19	neutral	0.58	neutral	4.6	neutral	1.18	neutral	-0.64	neutral_impact	-1.18	0.91	neutral	0.96	neutral	-0.64	0.10	neutral	0.48	0.65	0.32	neutral	0.16	neutral	0.21	neutral	0.27	neutral	5	0.31	neutral	0.7	deleterious	-6	neutral	0.19	neutral	-0.16	medium_impact	0.37	medium_impact	-2.11	low_impact	0.64	0.9	22.57	20.88	0.38	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9140	9140	C	G	MI.1310	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	614	205	A	G	gCt/gGt	6.14	1	0	probably_damaging	0.99	neutral	0.21	neutral	4.31	neutral	-1.67	deleterious	-3.13	low_impact	1.94	0.59	damaging	0.68	neutral	4.05	23.70	deleterious	0.26	0.65	NA	NA	0.85	disease	0.51	disease	0.49	neutral	0	1	deleterious	0.11	neutral	-2	neutral	0.87	deleterious	-2.65	low_impact	-0.03	medium_impact	0.57	medium_impact	0.71	0.9	15.93	18.3	0.47	N	0.86	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4633	4633	C	T	MI.13100	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	164	55	A	V	gCt/gTt	4.17	1	0	probably_damaging	1	neutral	0.19	neutral	4.21	deleterious	-4.75	deleterious	-3.73	medium_impact	3.17	0.88	neutral	0.44	neutral	4.21	23.90	deleterious	0.03	0.35	0.79	disease	0.88	disease	0.63	disease	0.68	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	-0.14	medium_impact	1.52	medium_impact	0.65	0.8	0.58	7.14	0.62	P	0.82	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4635	4635	G	A	MI.13101	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	166	56	A	T	Gcc/Acc	-8.72	0	0	possibly_damaging	0.87	neutral	0.81	neutral	4.51	deleterious	-3.35	deleterious	-2.54	low_impact	1.03	0.87	neutral	0.46	neutral	2.86	21.70	deleterious	0.08	0.35	0.28	neutral	0.51	disease	0.32	neutral	0.27	neutral	5	0.85	neutral	0.47	deleterious	-3	neutral	0.70	deleterious	-1.55	low_impact	0.56	medium_impact	-0.28	medium_impact	0.68	0.85	0.29	7.4	0.29	N	0.70	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4635	4635	G	T	MI.13102	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	166	56	A	S	Gcc/Tcc	-8.72	0	0	benign	0.39	neutral	0.86	neutral	4.74	neutral	-2.51	neutral	-1.49	neutral_impact	0.53	0.86	neutral	0.92	neutral	2.06	16.62	deleterious	0.15	0.45	0.31	neutral	0.62	disease	0.33	neutral	0.21	neutral	6	0.28	neutral	0.74	deleterious	-6	neutral	0.56	deleterious	-0.62	medium_impact	0.65	medium_impact	-0.7	medium_impact	0.50	0.8	0.29	7.4	0.23	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4635	4635	G	C	MI.13103	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	166	56	A	P	Gcc/Ccc	-8.72	0	0	probably_damaging	0.99	neutral	0.13	neutral	4.4	deleterious	-6.09	deleterious	-3.91	medium_impact	3.17	0.76	neutral	0.11	damaging	3.74	23.30	deleterious	0.03	0.35	0.24	neutral	0.92	disease	0.68	disease	0.73	disease	5	0.99	deleterious	0.07	neutral	1	deleterious	0.81	deleterious	-2.62	low_impact	-0.25	medium_impact	1.52	medium_impact	0.43	0.8	0.29	7.4	0.32	N	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4636	4636	C	A	MI.13104	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	167	56	A	D	gCc/gAc	-0.2	0	0	probably_damaging	0.97	neutral	0.26	neutral	4.41	deleterious	-5.61	deleterious	-4.42	high_impact	3.51	0.83	neutral	0.12	damaging	4.35	24.10	deleterious	0.02	0.35	0.65	disease	0.93	disease	0.66	disease	0.75	disease	5	0.98	neutral	0.15	neutral	2	deleterious	0.87	deleterious	-2.18	low_impact	-0.04	medium_impact	1.81	medium_impact	0.26	0.8	0.29	7.4	0.31	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4636	4636	C	T	MI.13105	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	167	56	A	V	gCc/gTc	-0.2	0	0	probably_damaging	0.96	neutral	0.24	neutral	4.47	deleterious	-4.7	deleterious	-3.35	medium_impact	2.54	0.88	neutral	0.18	damaging	4.34	24.10	deleterious	0.06	0.35	0.33	neutral	0.83	disease	0.57	disease	0.68	disease	4	0.97	neutral	0.14	neutral	1	deleterious	0.78	deleterious	-2.06	low_impact	-0.07	medium_impact	0.99	medium_impact	0.69	0.85	0.29	7.4	0.38	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4636	4636	C	G	MI.13106	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	167	56	A	G	gCc/gGc	-0.2	0	0	possibly_damaging	0.87	neutral	0.23	neutral	4.63	neutral	-1.6	deleterious	-3.07	medium_impact	1.94	0.89	neutral	0.22	damaging	3.83	23.40	deleterious	0.13	0.4	0.63	disease	0.83	disease	0.52	disease	0.69	disease	4	0.91	neutral	0.18	neutral	0	NA	0.79	deleterious	-1.55	low_impact	-0.08	medium_impact	0.49	medium_impact	0.58	0.8	0.29	7.4	0.43	N	0.49	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4638	4638	A	T	MI.13107	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	169	57	I	F	Atc/Ttc	-10.33	0	0.01	possibly_damaging	0.55	neutral	0.45	neutral	4.61	neutral	-1.18	neutral	-1	low_impact	1.68	0.86	neutral	0.51	neutral	3.38	23.00	deleterious	0.15	0.4	0.68	disease	0.79	disease	0.57	disease	0.72	disease	4	0.57	neutral	0.45	neutral	-3	neutral	0.69	deleterious	-0.88	medium_impact	0.16	medium_impact	0.27	medium_impact	0.57	0.8	0.86	7.85	0.27	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4638	4638	A	G	MI.13108	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	169	57	I	V	Atc/Gtc	-10.33	0	0.01	benign	0.06	neutral	0.38	neutral	4.57	neutral	-0.33	neutral	0.82	neutral_impact	0.42	0.96	neutral	0.93	neutral	0.00	2.56	deleterious	0.29	0.45	0.45	neutral	0.39	neutral	0.46	neutral	0.43	neutral	1	0.58	neutral	0.66	deleterious	-6	neutral	0.21	neutral	0.3	medium_impact	0.09	medium_impact	-0.79	medium_impact	0.32	0.8	0.86	7.85	0.37	N	0.59	polymorphism	1	0.01	rs878960801	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4638	4638	A	C	MI.13109	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	169	57	I	L	Atc/Ctc	-10.33	0	0.01	benign	0.06	neutral	0.61	neutral	4.79	neutral	0.74	neutral	-0.07	neutral_impact	0.51	0.88	neutral	0.48	neutral	1.83	15.17	deleterious	0.19	0.45	0.41	neutral	0.6	disease	0.5	neutral	0.48	neutral	0	0.32	neutral	0.78	deleterious	-6	neutral	0.27	neutral	0.3	medium_impact	0.32	medium_impact	-0.72	medium_impact	0.51	0.8	0.86	7.85	0.25	N	0.56	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9142	9142	G	C	MI.1311	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	616	206	V	L	Gtc/Ctc	-10.05	0	0	benign	0.19	deleterious	0	neutral	3.75	deleterious	-3.62	deleterious	-2.62	high_impact	4.15	0.61	neutral	0.59	neutral	3.68	23.30	deleterious	0.31	0.65	NA	NA	0.88	disease	0.68	disease	0.73	disease	5	1	deleterious	0.41	neutral	2	deleterious	0.38	neutral	-0.16	medium_impact	-1.4	low_impact	2.46	high_impact	0.54	0.9	48.23	8.69	0.43	N	0.72	disease_causing	0.65	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4639	4639	T	G	MI.13110	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	170	57	I	S	aTc/aGc	3.25	0.07	0.03	benign	0.14	neutral	0.87	neutral	4.5	neutral	-2.24	neutral	1.69	medium_impact	2.04	0.87	neutral	0.6	neutral	2.33	18.39	deleterious	0.05	0.35	0.48	neutral	0.82	disease	0.56	disease	0.71	disease	4	0.06	neutral	0.87	deleterious	-3	neutral	0.39	neutral	-0.08	medium_impact	0.67	medium_impact	0.57	medium_impact	0.33	0.8	0.86	7.85	0.25	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4639	4639	T	C	MI.13111	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	170	57	I	T	aTc/aCc	3.25	0.07	0.03	benign	0	neutral	1	neutral	4.55	neutral	-1.31	neutral	5.01	neutral_impact	-0.78	0.93	neutral	0.93	neutral	-1.36	0.00	neutral	0.11	0.4	0.33	neutral	0.11	neutral	0.27	neutral	0.23	neutral	5	0	neutral	1	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	1.87	high_impact	-1.8	low_impact	0.35	0.8	0.86	7.85	0.27	N	0.01	polymorphism	1	0.01	rs41510547	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4639	4639	T	A	MI.13112	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	170	57	I	N	aTc/aAc	3.25	0.07	0.03	benign	0.27	neutral	0.15	neutral	4.47	deleterious	-3.33	neutral	0.67	medium_impact	2.17	0.88	neutral	0.47	neutral	2.64	20.40	deleterious	0.12	0.4	0.77	disease	0.89	disease	0.57	disease	0.74	disease	5	0.82	neutral	0.44	neutral	-3	neutral	0.62	deleterious	-0.4	medium_impact	-0.21	medium_impact	0.68	medium_impact	0.38	0.8	0.86	7.85	0.46	N	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4640	4640	C	A	MI.13113	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	171	57	I	M	atC/atA	-0.2	0	0.02	possibly_damaging	0.73	neutral	0.2	neutral	4.62	neutral	-0.6	neutral	-0.07	neutral_impact	0.54	0.9	neutral	0.65	neutral	3.48	23.10	deleterious	0.28	0.45	0.67	disease	0.61	disease	0.44	neutral	0.41	neutral	2	0.85	neutral	0.24	neutral	-3	neutral	0.70	deleterious	-1.19	low_impact	-0.13	medium_impact	-0.69	medium_impact	0.68	0.85	0.86	7.85	0.57	P	0.67	disease_causing_automatic	0	0.01	rs387906426	Pathogenic	Leber's_optic_atrophy	24757	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	CPD	0.3	C4640A	LHON	+	-	Reported	4	P	P	P	neutral
chrM	4640	4640	C	G	MI.13114	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	171	57	I	M	atC/atG	-0.2	0	0.02	possibly_damaging	0.73	neutral	0.2	neutral	4.62	neutral	-0.6	neutral	-0.07	neutral_impact	0.54	0.9	neutral	0.65	neutral	3.00	22.20	deleterious	0.28	0.45	0.67	disease	0.61	disease	0.44	neutral	0.41	neutral	2	0.85	neutral	0.24	neutral	-3	neutral	0.70	deleterious	-1.19	low_impact	-0.13	medium_impact	-0.69	medium_impact	0.68	0.85	0.86	7.85	0.53	N	0.67	disease_causing_automatic	0	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4641	4641	A	G	MI.13115	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	172	58	K	E	Aag/Gag	-7.8	0	0	probably_damaging	1	neutral	0.26	neutral	4.31	deleterious	-3.75	deleterious	-3.73	high_impact	4.08	0.87	neutral	0.12	damaging	3.93	23.50	deleterious	0.07	0.35	0.69	disease	0.83	disease	0.76	disease	0.72	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.04	medium_impact	2.29	high_impact	0.55	0.8	NA	NA	0.44	N	0.91	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4641	4641	A	C	MI.13116	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	172	58	K	Q	Aag/Cag	-7.8	0	0	probably_damaging	1	neutral	0.29	neutral	4.3	deleterious	-3.82	deleterious	-3.73	high_impact	3.73	0.86	neutral	0.12	damaging	3.35	22.90	deleterious	0.13	0.4	0.71	disease	0.81	disease	0.71	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.01	medium_impact	2	medium_impact	0.64	0.8	NA	NA	0.35	N	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4642	4642	A	C	MI.13117	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	173	58	K	T	aAg/aCg	8.55	1	0	probably_damaging	1	neutral	0.38	neutral	4.3	deleterious	-4.19	deleterious	-5.6	medium_impact	3.1	0.85	neutral	0.12	damaging	3.58	23.20	deleterious	0.07	0.35	0.56	disease	0.81	disease	0.74	disease	0.71	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.09	medium_impact	1.47	medium_impact	0.40	0.8	NA	NA	0.57	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4642	4642	A	T	MI.13118	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	173	58	K	M	aAg/aTg	8.55	1	0	probably_damaging	1	neutral	0.22	neutral	4.29	deleterious	-6.21	deleterious	-5.6	medium_impact	2.92	0.87	neutral	0.12	damaging	3.91	23.50	deleterious	0.04	0.35	0.64	disease	0.81	disease	0.72	disease	0.7	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.1	medium_impact	1.31	medium_impact	0.39	0.8	NA	NA	0.56	N	0.45	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4643	4643	G	T	MI.13119	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	174	58	K	N	aaG/aaT	6.94	1	0	probably_damaging	1	neutral	0.29	neutral	4.3	deleterious	-4.41	deleterious	-4.67	medium_impact	3.27	0.88	neutral	0.11	damaging	3.93	23.50	deleterious	0.12	0.4	0.73	disease	0.83	disease	0.72	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.01	medium_impact	1.61	medium_impact	0.38	0.8	NA	NA	0.61	P	0.69	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9142	9142	G	T	MI.1312	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	616	206	V	F	Gtc/Ttc	-10.05	0	0	possibly_damaging	0.8	deleterious	0	neutral	3.68	deleterious	-5.18	deleterious	-4.4	high_impact	4.5	0.61	neutral	0.54	neutral	3.97	23.60	deleterious	0.14	0.65	NA	NA	0.95	disease	0.74	disease	0.87	disease	7	1	deleterious	0.1	neutral	5	deleterious	0.81	deleterious	-1.33	low_impact	-1.4	low_impact	2.76	high_impact	0.60	0.9	48.23	8.69	0.49	N	1.00	disease_causing	0.95	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4643	4643	G	C	MI.13120	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	174	58	K	N	aaG/aaC	6.94	1	0	probably_damaging	1	neutral	0.29	neutral	4.3	deleterious	-4.41	deleterious	-4.67	medium_impact	3.27	0.88	neutral	0.11	damaging	3.83	23.40	deleterious	0.12	0.4	0.73	disease	0.83	disease	0.72	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.01	medium_impact	1.61	medium_impact	0.38	0.8	NA	NA	0.61	P	0.69	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4644	4644	T	G	MI.13121	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	175	59	Y	D	Tat/Gat	0.49	0.99	0	probably_damaging	1	neutral	0.08	neutral	4.3	deleterious	-7.78	deleterious	-9.33	high_impact	4.12	0.88	neutral	0.13	damaging	3.84	23.40	deleterious	0.01	0.35	0.64	disease	0.89	disease	0.81	disease	0.74	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.38	medium_impact	2.32	high_impact	0.15	0.8	0.29	6.97	0.57	P	0.96	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4644	4644	T	A	MI.13122	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	175	59	Y	N	Tat/Aat	0.49	0.99	0	probably_damaging	1	neutral	0.07	neutral	4.3	deleterious	-6.82	deleterious	-8.39	high_impact	3.77	0.87	neutral	0.15	damaging	4.12	23.80	deleterious	0.02	0.35	0.64	disease	0.87	disease	0.74	disease	0.72	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.42	medium_impact	2.03	high_impact	0.22	0.8	0.29	6.97	0.53	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4644	4644	T	C	MI.13123	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	175	59	Y	H	Tat/Cat	0.49	0.99	0	probably_damaging	1	neutral	0.12	neutral	4.3	deleterious	-6.77	deleterious	-4.66	high_impact	3.77	0.86	neutral	0.12	damaging	3.56	23.10	deleterious	0.05	0.35	0.77	disease	0.78	disease	0.82	disease	0.71	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.27	medium_impact	2.03	high_impact	0.26	0.8	0.29	6.97	0.54	N	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4645	4645	A	G	MI.13124	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	176	59	Y	C	tAt/tGt	7.4	1	0	probably_damaging	1	deleterious	0.04	neutral	4.3	deleterious	-7.17	deleterious	-8.4	high_impact	4.12	0.85	neutral	0.11	damaging	3.44	23.00	deleterious	0.02	0.35	0.85	disease	0.86	disease	0.79	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-0.56	medium_impact	2.32	high_impact	0.19	0.8	0.29	6.97	0.65	P	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4645	4645	A	C	MI.13125	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	176	59	Y	S	tAt/tCt	7.4	1	0	probably_damaging	1	neutral	0.2	neutral	4.33	deleterious	-5.86	deleterious	-8.39	high_impact	3.57	0.9	neutral	0.19	damaging	3.61	23.20	deleterious	0.02	0.35	0.49	neutral	0.87	disease	0.74	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.13	medium_impact	1.86	medium_impact	0.28	0.8	0.29	6.97	0.62	P	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4645	4645	A	T	MI.13126	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	176	59	Y	F	tAt/tTt	7.4	1	0	probably_damaging	1	neutral	0.33	neutral	4.42	neutral	-2.71	deleterious	-3.73	high_impact	4.12	0.83	neutral	0.12	damaging	3.33	22.90	deleterious	0.13	0.4	0.77	disease	0.82	disease	0.72	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.04	medium_impact	2.32	high_impact	0.44	0.8	0.29	6.97	0.66	P	0.80	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4647	4647	T	G	MI.13127	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	178	60	F	V	Ttc/Gtc	-2.04	0	0	probably_damaging	1	neutral	0.09	neutral	4.41	neutral	-1.83	deleterious	-6.49	high_impact	4.09	0.76	neutral	0.15	damaging	4.03	23.70	deleterious	0.03	0.35	0.66	disease	0.87	disease	0.67	disease	0.71	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.35	medium_impact	2.3	high_impact	0.22	0.8	NA	NA	0.37	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4647	4647	T	C	MI.13128	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	178	60	F	L	Ttc/Ctc	-2.04	0	0	probably_damaging	1	neutral	0.3	neutral	4.47	neutral	-1	deleterious	-5.55	medium_impact	2.55	0.91	neutral	0.55	neutral	4.02	23.60	deleterious	0.04	0.35	0.2	neutral	0.8	disease	0.6	disease	0.56	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0	medium_impact	1	medium_impact	0.40	0.8	NA	NA	0.46	N	0.91	polymorphism	1	0.10	rs879192007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4647	4647	T	A	MI.13129	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	178	60	F	I	Ttc/Atc	-2.04	0	0	probably_damaging	1	neutral	0.09	neutral	4.46	neutral	-2.15	deleterious	-5.56	high_impact	4.09	0.91	neutral	0.15	damaging	4.42	24.20	deleterious	0.05	0.35	0.65	disease	0.84	disease	0.66	disease	0.71	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.35	medium_impact	2.3	high_impact	0.28	0.8	NA	NA	0.44	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9142	9142	G	A	MI.1313	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	616	206	V	I	Gtc/Atc	-10.05	0	0	benign	0.03	neutral	0.06	neutral	4.04	neutral	-1.16	neutral	-0.85	medium_impact	2.31	0.64	neutral	0.63	neutral	3.69	23.30	deleterious	0.37	0.65	NA	NA	0.7	disease	0.62	disease	0.5	disease	0	0.94	neutral	0.52	deleterious	-3	neutral	0.27	neutral	0.68	medium_impact	-0.38	medium_impact	0.88	medium_impact	0.74	0.9	48.23	8.69	0.4	N	0.06	polymorphism	0.64	0.06	rs200660596	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4648	4648	T	G	MI.13130	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	179	60	F	C	tTc/tGc	5.55	1	0	probably_damaging	1	neutral	0.05	neutral	4.27	deleterious	-5.31	deleterious	-7.43	high_impact	3.75	0.81	neutral	0.13	damaging	3.92	23.50	deleterious	0.02	0.35	0.91	disease	0.86	disease	0.7	disease	0.67	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.5	medium_impact	2.01	high_impact	0.15	0.8	NA	NA	0.6	P	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4648	4648	T	C	MI.13131	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	179	60	F	S	tTc/tCc	5.55	1	0	probably_damaging	1	neutral	0.13	neutral	4.3	deleterious	-3.78	deleterious	-7.44	high_impact	3.75	0.87	neutral	0.17	damaging	4.05	23.70	deleterious	0.01	0.35	0.32	neutral	0.88	disease	0.67	disease	0.71	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	-0.25	medium_impact	2.01	high_impact	0.16	0.8	NA	NA	0.63	P	0.95	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	T4648C	PEG	+	-	Reported	1	.	P	P	damaging
chrM	4648	4648	T	A	MI.13132	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	179	60	F	Y	tTc/tAc	5.55	1	0	probably_damaging	1	neutral	0.42	neutral	4.37	deleterious	-3.85	deleterious	-2.79	medium_impact	2.77	0.83	neutral	0.12	damaging	4.05	23.70	deleterious	0.07	0.35	0.71	disease	0.8	disease	0.65	disease	0.67	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.13	medium_impact	1.19	medium_impact	0.30	0.8	NA	NA	0.56	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4649	4649	C	A	MI.13133	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	180	60	F	L	ttC/ttA	5.78	1	0	probably_damaging	1	neutral	0.3	neutral	4.47	neutral	-1	deleterious	-5.55	medium_impact	2.55	0.91	neutral	0.55	neutral	4.55	24.40	deleterious	0.04	0.35	0.2	neutral	0.8	disease	0.6	disease	0.56	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0	medium_impact	1	medium_impact	0.40	0.8	NA	NA	0.6	P	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4649	4649	C	G	MI.13134	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	180	60	F	L	ttC/ttG	5.78	1	0	probably_damaging	1	neutral	0.3	neutral	4.47	neutral	-1	deleterious	-5.55	medium_impact	2.55	0.91	neutral	0.55	neutral	4.22	23.90	deleterious	0.04	0.35	0.2	neutral	0.8	disease	0.6	disease	0.56	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0	medium_impact	1	medium_impact	0.40	0.8	NA	NA	0.6	P	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4650	4650	C	G	MI.13135	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	181	61	L	V	Ctc/Gtc	-4.35	0	0	probably_damaging	1	neutral	0.19	neutral	4.25	neutral	-0.97	deleterious	-2.65	medium_impact	2.4	0.95	neutral	0.28	damaging	3.28	22.80	deleterious	0.14	0.4	0.48	neutral	0.64	disease	0.55	disease	0.62	disease	2	1	deleterious	0.1	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.14	medium_impact	0.88	medium_impact	0.56	0.8	NA	NA	0.4	N	0.20	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4650	4650	C	A	MI.13136	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	181	61	L	I	Ctc/Atc	-4.35	0	0	probably_damaging	1	neutral	0.28	neutral	4.22	neutral	-0.9	neutral	-1.79	low_impact	1.63	0.94	neutral	0.37	neutral	2.86	21.70	deleterious	0.17	0.45	0.53	disease	0.62	disease	0.39	neutral	0.22	neutral	6	1	deleterious	0.14	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	-0.02	medium_impact	0.23	medium_impact	0.48	0.8	NA	NA	0.36	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4650	4650	C	T	MI.13137	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	181	61	L	F	Ctc/Ttc	-4.35	0	0	probably_damaging	1	neutral	0.4	neutral	4.21	deleterious	-3.22	deleterious	-3.54	medium_impact	2.48	0.95	neutral	0.17	damaging	3.81	23.40	deleterious	0.07	0.35	0.23	neutral	0.76	disease	0.58	disease	0.57	disease	1	1	deleterious	0.2	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.11	medium_impact	0.94	medium_impact	0.46	0.8	NA	NA	0.3	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4651	4651	T	C	MI.13138	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	182	61	L	P	cTc/cCc	-1.35	0	0	probably_damaging	1	deleterious	0.02	neutral	4.07	deleterious	-5.54	deleterious	-6.31	high_impact	3.56	0.85	neutral	0.11	damaging	3.76	23.30	deleterious	0.01	0.35	0.86	disease	0.84	disease	0.75	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-0.73	medium_impact	1.85	medium_impact	0.37	0.8	NA	NA	0.32	N	0.94	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4651	4651	T	A	MI.13139	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	182	61	L	H	cTc/cAc	-1.35	0	0	probably_damaging	1	neutral	0.06	neutral	4.07	deleterious	-5.51	deleterious	-6.29	high_impact	3.9	0.88	neutral	0.1	damaging	3.99	23.60	deleterious	0.02	0.35	0.85	disease	0.8	disease	0.71	disease	0.69	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.46	medium_impact	2.14	high_impact	0.36	0.8	NA	NA	0.39	N	0.85	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9143	9143	T	G	MI.1314	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	617	206	V	G	gTc/gGc	6.14	1	0	possibly_damaging	0.83	deleterious	0	neutral	3.66	deleterious	-6.16	deleterious	-6.21	high_impact	4.5	0.65	neutral	0.66	neutral	3.89	23.50	deleterious	0.16	0.65	NA	NA	0.91	disease	0.72	disease	0.77	disease	5	1	deleterious	0.09	neutral	5	deleterious	0.82	deleterious	-1.41	low_impact	-1.4	low_impact	2.76	high_impact	0.45	0.9	48.23	8.69	0.48	N	0.95	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4651	4651	T	G	MI.13140	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	182	61	L	R	cTc/cGc	-1.35	0	0	probably_damaging	1	deleterious	0.04	neutral	4.07	deleterious	-4.98	deleterious	-5.37	high_impact	3.9	0.94	neutral	0.14	damaging	4.03	23.60	deleterious	0.01	0.35	0.81	disease	0.89	disease	0.73	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-0.56	medium_impact	2.14	high_impact	0.24	0.8	NA	NA	0.47	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4653	4653	A	C	MI.13141	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	184	62	T	P	Acg/Ccg	-11.25	0	0	possibly_damaging	0.55	neutral	0.2	neutral	4.5	neutral	-2.9	deleterious	-4.47	medium_impact	2.21	0.75	neutral	0.35	neutral	3.26	22.80	deleterious	0.04	0.35	0.93	disease	0.92	disease	0.7	disease	0.67	disease	3	0.79	neutral	0.33	neutral	0	NA	0.80	deleterious	-0.88	medium_impact	-0.13	medium_impact	0.72	medium_impact	0.35	0.8	NA	NA	0.31	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4653	4653	A	T	MI.13142	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	184	62	T	S	Acg/Tcg	-11.25	0	0	benign	0.14	neutral	0.4	neutral	4.54	neutral	-1.03	deleterious	-2.98	medium_impact	2.81	0.89	neutral	0.54	neutral	1.51	13.38	neutral	0.32	0.5	0.86	disease	0.77	disease	0.54	disease	0.66	disease	3	0.53	neutral	0.63	deleterious	-3	neutral	0.42	neutral	-0.08	medium_impact	0.11	medium_impact	1.22	medium_impact	0.70	0.85	NA	NA	0.33	N	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4653	4653	A	G	MI.13143	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	184	62	T	A	Acg/Gcg	-11.25	0	0	benign	0.01	neutral	0.52	neutral	4.56	neutral	-0.29	deleterious	-3.33	medium_impact	2.21	0.89	neutral	0.75	neutral	1.58	13.72	neutral	0.25	0.45	0.72	disease	0.62	disease	0.49	neutral	0.34	neutral	3	0.47	neutral	0.76	deleterious	-3	neutral	0.24	neutral	1.03	medium_impact	0.23	medium_impact	0.72	medium_impact	0.34	0.8	NA	NA	0.32	N	0.78	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4654	4654	C	A	MI.13144	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	185	62	T	K	aCg/aAg	0.72	0	0	benign	0.34	neutral	0.28	neutral	4.51	neutral	-2.38	deleterious	-4.41	high_impact	3.7	0.87	neutral	0.37	neutral	4.07	23.70	deleterious	0.04	0.35	0.91	disease	0.91	disease	0.66	disease	0.67	disease	3	0.66	neutral	0.47	deleterious	-2	neutral	0.64	deleterious	-0.53	medium_impact	-0.02	medium_impact	1.97	medium_impact	0.48	0.8	NA	NA	0.41	N	0.94	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4654	4654	C	T	MI.13145	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	185	62	T	M	aCg/aTg	0.72	0	0	benign	0.02	neutral	0.23	neutral	4.55	neutral	0.37	deleterious	-3.35	medium_impact	2.61	0.95	neutral	0.82	neutral	2.66	20.50	deleterious	0.06	0.35	0.79	disease	0.81	disease	0.51	disease	0.36	neutral	3	0.76	neutral	0.61	deleterious	-3	neutral	0.28	neutral	0.75	medium_impact	-0.08	medium_impact	1.05	medium_impact	0.50	0.8	NA	NA	0.37	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4656	4656	C	G	MI.13146	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	187	63	Q	E	Caa/Gaa	-12.63	0	0	probably_damaging	0.99	neutral	0.28	neutral	4.57	neutral	-0.89	deleterious	-2.8	high_impact	4.12	0.81	neutral	0.08	damaging	2.92	21.90	deleterious	0.16	0.45	0.66	disease	0.82	disease	0.73	disease	0.71	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-2.62	low_impact	-0.02	medium_impact	2.32	high_impact	0.49	0.8	NA	NA	0.31	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4656	4656	C	A	MI.13147	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	187	63	Q	K	Caa/Aaa	-12.63	0	0	probably_damaging	0.99	neutral	0.3	neutral	4.57	neutral	-0.94	deleterious	-3.73	high_impact	3.77	0.78	neutral	0.06	damaging	3.84	23.40	deleterious	0.08	0.35	0.6	disease	0.91	disease	0.76	disease	0.74	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-2.62	low_impact	0	medium_impact	2.03	high_impact	0.42	0.8	NA	NA	0.32	N	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4657	4657	A	C	MI.13148	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	188	63	Q	P	cAa/cCa	5.55	1	0	probably_damaging	1	neutral	0.2	neutral	4.5	deleterious	-3.01	deleterious	-5.6	high_impact	4.12	0.76	neutral	0.07	damaging	3.25	22.80	deleterious	0.03	0.35	0.82	disease	0.91	disease	0.78	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	-0.13	medium_impact	2.32	high_impact	0.32	0.8	NA	NA	0.68	P	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4657	4657	A	T	MI.13149	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	188	63	Q	L	cAa/cTa	5.55	1	0	probably_damaging	1	neutral	0.68	neutral	4.51	neutral	-2.45	deleterious	-6.53	high_impact	3.77	0.75	neutral	0.06	damaging	3.71	23.30	deleterious	0.03	0.35	0.22	neutral	0.92	disease	0.68	disease	0.72	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.39	medium_impact	2.03	high_impact	0.28	0.8	NA	NA	0.52	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9143	9143	T	A	MI.1315	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	617	206	V	D	gTc/gAc	6.14	1	0	probably_damaging	0.94	deleterious	0	neutral	3.66	deleterious	-5.95	deleterious	-6.2	high_impact	4.5	0.66	neutral	0.56	neutral	4.52	24.30	deleterious	0.1	0.65	NA	NA	0.94	disease	0.8	disease	0.86	disease	7	1	deleterious	0.03	neutral	6	deleterious	0.89	deleterious	-1.89	low_impact	-1.4	low_impact	2.76	high_impact	0.52	0.9	48.23	8.69	0.51	P	0.99	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4657	4657	A	G	MI.13150	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	188	63	Q	R	cAa/cGa	5.55	1	0	probably_damaging	0.99	neutral	0.35	neutral	4.53	neutral	-1.67	deleterious	-3.73	high_impact	4.12	0.83	neutral	0.07	damaging	3.36	22.90	deleterious	0.08	0.35	0.66	disease	0.91	disease	0.77	disease	0.74	disease	5	0.99	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-2.62	low_impact	0.06	medium_impact	2.32	high_impact	0.31	0.8	NA	NA	0.68	P	0.87	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4658	4658	A	T	MI.13151	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	189	63	Q	H	caA/caT	8.55	1	0	probably_damaging	1	neutral	0.54	neutral	4.5	neutral	-2.79	deleterious	-4.67	high_impact	4.12	0.76	neutral	0.06	damaging	3.48	23.10	deleterious	0.08	0.35	0.81	disease	0.84	disease	0.78	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.25	medium_impact	2.32	high_impact	0.65	0.8	NA	NA	0.64	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4658	4658	A	C	MI.13152	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	189	63	Q	H	caA/caC	8.55	1	0	probably_damaging	1	neutral	0.54	neutral	4.5	neutral	-2.79	deleterious	-4.67	high_impact	4.12	0.76	neutral	0.06	damaging	3.32	22.90	deleterious	0.08	0.35	0.81	disease	0.84	disease	0.78	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.25	medium_impact	2.32	high_impact	0.65	0.8	NA	NA	0.63	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4659	4659	G	C	MI.13153	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	190	64	A	P	Gca/Cca	2.1	1	0.01	possibly_damaging	0.85	neutral	0.12	neutral	4.41	deleterious	-4.7	deleterious	-4.13	high_impact	3.86	0.84	neutral	0.42	neutral	3.58	23.20	deleterious	0.03	0.35	0.85	disease	0.95	disease	0.76	disease	0.75	disease	5	0.94	neutral	0.14	neutral	1	deleterious	0.87	deleterious	-1.49	low_impact	-0.27	medium_impact	2.11	high_impact	0.65	0.8	0.58	6.94	0.62	P	0.94	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4659	4659	G	T	MI.13154	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	190	64	A	S	Gca/Tca	2.1	1	0.01	benign	0.02	neutral	0.46	neutral	4.49	neutral	-1.34	neutral	-2.02	low_impact	1.24	0.87	neutral	0.9	neutral	0.75	9.13	deleterious	0.25	0.45	0.5	neutral	0.86	disease	0.54	disease	0.28	neutral	4	0.52	neutral	0.72	deleterious	-6	neutral	0.30	neutral	0.75	medium_impact	0.17	medium_impact	-0.1	medium_impact	0.65	0.8	0.58	6.94	0.39	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4659	4659	G	A	MI.13155	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	190	64	A	T	Gca/Aca	2.1	1	0.01	benign	0.06	neutral	0.3	neutral	4.45	neutral	-2.11	deleterious	-2.75	low_impact	1.76	0.9	neutral	0.73	neutral	1.11	11.29	neutral	0.13	0.4	0.65	disease	0.87	disease	0.44	neutral	0.22	neutral	6	0.67	neutral	0.62	deleterious	-6	neutral	0.32	neutral	0.3	medium_impact	0	medium_impact	0.34	medium_impact	0.71	0.85	0.58	6.94	0.61	P	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	2.67	G4659A	possible PD risk factor	+	-	Reported	1	.	P	P	damaging
chrM	4660	4660	C	T	MI.13156	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	191	64	A	V	gCa/gTa	1.64	1	0	possibly_damaging	0.44	neutral	0.36	neutral	4.5	neutral	-2.15	deleterious	-3.36	medium_impact	2.39	0.95	neutral	0.57	neutral	2.56	19.88	deleterious	0.08	0.35	0.54	disease	0.92	disease	0.58	disease	0.58	disease	2	0.6	neutral	0.46	neutral	0	NA	0.67	deleterious	-0.7	medium_impact	0.07	medium_impact	0.87	medium_impact	0.79	0.85	0.58	6.94	0.56	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4660	4660	C	G	MI.13157	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	191	64	A	G	gCa/gGa	1.64	1	0	benign	0.33	neutral	0.21	neutral	4.48	neutral	-2.32	deleterious	-3.34	medium_impact	3.31	0.91	neutral	0.55	neutral	2.16	17.22	deleterious	0.19	0.45	0.8	disease	0.91	disease	0.63	disease	0.68	disease	4	0.75	neutral	0.44	neutral	-3	neutral	0.60	deleterious	-0.52	medium_impact	-0.11	medium_impact	1.64	medium_impact	0.71	0.85	0.58	6.94	0.55	P	0.47	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4660	4660	C	A	MI.13158	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	191	64	A	E	gCa/gAa	1.64	1	0	possibly_damaging	0.58	neutral	0.16	neutral	4.45	deleterious	-3.02	deleterious	-4.05	medium_impact	3.31	0.9	neutral	0.41	neutral	4.06	23.70	deleterious	0.02	0.35	0.8	disease	0.95	disease	0.73	disease	0.78	disease	6	0.84	neutral	0.29	neutral	0	NA	0.77	deleterious	-0.93	medium_impact	-0.19	medium_impact	1.64	medium_impact	0.41	0.8	0.58	6.94	0.59	P	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4662	4662	A	T	MI.13159	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	193	65	T	S	Acc/Tcc	-6.65	0	0	possibly_damaging	0.51	neutral	0.55	neutral	4.6	neutral	-1.1	deleterious	-3.45	low_impact	1.47	0.86	neutral	0.9	neutral	2.58	19.96	deleterious	0.35	0.5	0.26	neutral	0.73	disease	0.4	neutral	0.21	neutral	6	0.47	neutral	0.52	deleterious	-3	neutral	0.54	deleterious	-0.81	medium_impact	0.26	medium_impact	0.09	medium_impact	0.61	0.8	0.29	10.05	0.27	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9143	9143	T	C	MI.1316	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	617	206	V	A	gTc/gCc	6.14	1	0	benign	0.39	deleterious	0	neutral	3.77	deleterious	-4.02	deleterious	-3.52	high_impact	3.94	0.6	neutral	0.65	neutral	3.65	23.20	deleterious	0.26	0.65	NA	NA	0.73	disease	0.69	disease	0.69	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.57	deleterious	-0.57	medium_impact	-1.4	low_impact	2.28	high_impact	0.29	0.9	48.23	8.69	0.51	P	0.84	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4662	4662	A	C	MI.13160	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	193	65	T	P	Acc/Ccc	-6.65	0	0	probably_damaging	0.99	neutral	0.13	neutral	4.57	neutral	-2.65	deleterious	-5.44	medium_impact	3.36	0.76	neutral	0.42	neutral	3.82	23.40	deleterious	0.04	0.35	0.84	disease	0.94	disease	0.73	disease	0.74	disease	5	0.99	deleterious	0.07	neutral	1	deleterious	0.87	deleterious	-2.62	low_impact	-0.25	medium_impact	1.68	medium_impact	0.32	0.8	0.29	10.05	0.34	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4662	4662	A	G	MI.13161	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	193	65	T	A	Acc/Gcc	-6.65	0	0	possibly_damaging	0.81	neutral	1	neutral	4.67	neutral	0.31	deleterious	-4.46	low_impact	0.88	0.84	neutral	0.61	neutral	3.76	23.30	deleterious	0.2	0.45	0.22	neutral	0.25	neutral	0.38	neutral	0.41	neutral	2	0.81	neutral	0.6	deleterious	-3	neutral	0.63	deleterious	-1.37	low_impact	1.87	high_impact	-0.4	medium_impact	0.31	0.8	0.29	10.05	0.24	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4663	4663	C	G	MI.13162	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	194	65	T	S	aCc/aGc	-0.43	0	0	possibly_damaging	0.51	neutral	0.55	neutral	4.6	neutral	-1.1	deleterious	-3.45	low_impact	1.47	0.86	neutral	0.9	neutral	2.21	17.55	deleterious	0.35	0.5	0.26	neutral	0.73	disease	0.4	neutral	0.21	neutral	6	0.47	neutral	0.52	deleterious	-3	neutral	0.54	deleterious	-0.81	medium_impact	0.26	medium_impact	0.09	medium_impact	0.61	0.8	0.29	10.05	0.26	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4663	4663	C	A	MI.13163	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	194	65	T	N	aCc/aAc	-0.43	0	0	probably_damaging	0.94	neutral	0.23	neutral	4.57	neutral	-2.35	deleterious	-4.46	medium_impact	3.01	0.88	neutral	0.55	neutral	3.57	23.10	deleterious	0.27	0.45	0.81	disease	0.89	disease	0.61	disease	0.69	disease	4	0.96	neutral	0.15	neutral	1	deleterious	0.82	deleterious	-1.89	low_impact	-0.08	medium_impact	1.39	medium_impact	0.51	0.8	0.29	10.05	0.38	N	0.88	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4663	4663	C	T	MI.13164	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	194	65	T	I	aCc/aTc	-0.43	0	0	probably_damaging	0.99	neutral	0.5	neutral	4.82	neutral	1.65	deleterious	-5.48	low_impact	1.18	0.9	neutral	0.56	neutral	3.73	23.30	deleterious	0.14	0.4	0.79	disease	0.92	disease	0.58	disease	0.62	disease	2	0.98	deleterious	0.26	neutral	-2	neutral	0.83	deleterious	-2.62	low_impact	0.21	medium_impact	-0.15	medium_impact	0.55	0.8	0.29	10.05	0.35	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4665	4665	G	T	MI.13165	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	196	66	A	S	Gca/Tca	-8.03	0	0	probably_damaging	1	neutral	0.51	neutral	4.87	neutral	1.14	deleterious	-2.8	low_impact	1.94	0.88	neutral	0.13	damaging	3.56	23.10	deleterious	0.13	0.4	0.34	neutral	0.88	disease	0.55	disease	0.67	disease	3	1	deleterious	0.26	neutral	-2	neutral	0.80	deleterious	-3.54	low_impact	0.22	medium_impact	0.49	medium_impact	0.48	0.8	NA	NA	0.27	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4665	4665	G	C	MI.13166	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	196	66	A	P	Gca/Cca	-8.03	0	0	probably_damaging	1	neutral	0.11	neutral	4.44	deleterious	-3.89	deleterious	-4.67	high_impact	3.63	0.81	neutral	0.12	damaging	3.73	23.30	deleterious	0.03	0.35	0.77	disease	0.93	disease	0.76	disease	0.75	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	-0.3	medium_impact	1.91	medium_impact	0.41	0.8	NA	NA	0.35	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4665	4665	G	A	MI.13167	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	196	66	A	T	Gca/Aca	-8.03	0	0	probably_damaging	1	neutral	0.28	neutral	4.47	neutral	-2.36	deleterious	-3.73	medium_impact	2.94	0.86	neutral	0.12	damaging	4.07	23.70	deleterious	0.08	0.35	0.51	disease	0.87	disease	0.65	disease	0.7	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.02	medium_impact	1.33	medium_impact	0.75	0.85	NA	NA	0.34	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4666	4666	C	A	MI.13168	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	197	66	A	E	gCa/gAa	7.17	1	0	probably_damaging	1	neutral	0.15	neutral	4.44	deleterious	-3.52	deleterious	-4.67	high_impact	3.98	0.89	neutral	0.13	damaging	4.38	24.10	deleterious	0.03	0.35	0.71	disease	0.94	disease	0.74	disease	0.79	disease	6	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.21	medium_impact	2.21	high_impact	0.34	0.8	NA	NA	0.69	P	0.99	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4666	4666	C	T	MI.13169	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	197	66	A	V	gCa/gTa	7.17	1	0	probably_damaging	1	neutral	0.32	neutral	4.45	neutral	-2.87	deleterious	-3.73	high_impact	3.98	0.83	neutral	0.13	damaging	4.35	24.10	deleterious	0.06	0.35	0.17	neutral	0.91	disease	0.65	disease	0.71	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	0.03	medium_impact	2.21	high_impact	0.74	0.85	NA	NA	0.58	P	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9145	9145	G	A	MI.1317	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	619	207	A	T	Gcc/Acc	-3.8	0	0.01	probably_damaging	1	deleterious	0.01	neutral	4.08	neutral	-2.7	deleterious	-3.54	medium_impact	3.17	0.58	damaging	0.48	neutral	4.35	24.10	deleterious	0.48	0.65	NA	NA	0.87	disease	0.64	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.89	deleterious	-3.6	low_impact	-0.84	medium_impact	1.62	medium_impact	0.84	0.9	48.67	8.68	0.34	N	0.80	disease_causing	0.57	0.27	.	.	.	.	.	.	COSM1155694	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4666	4666	C	G	MI.13170	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	197	66	A	G	gCa/gGa	7.17	1	0	probably_damaging	1	neutral	0.24	neutral	5.03	neutral	1.64	deleterious	-3.73	low_impact	1.67	0.93	neutral	0.15	damaging	3.83	23.40	deleterious	0.14	0.4	0.7	disease	0.89	disease	0.55	disease	0.66	disease	3	1	deleterious	0.12	neutral	-2	neutral	0.82	deleterious	-3.54	low_impact	-0.07	medium_impact	0.26	medium_impact	0.59	0.8	NA	NA	0.57	P	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4668	4668	T	A	MI.13171	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	199	67	S	T	Tcc/Acc	-5.73	0	0	probably_damaging	1	neutral	0.32	neutral	3.79	deleterious	-5.14	deleterious	-2.8	high_impact	3.68	0.88	neutral	0.13	damaging	3.68	23.30	deleterious	0.1	0.4	0.45	neutral	0.76	disease	0.62	disease	0.63	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.03	medium_impact	1.95	medium_impact	0.65	0.8	0.29	6.81	0.39	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4668	4668	T	G	MI.13172	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	199	67	S	A	Tcc/Gcc	-5.73	0	0	probably_damaging	1	neutral	1	neutral	3.86	deleterious	-3.42	deleterious	-2.8	low_impact	1.68	0.9	neutral	0.3	neutral	2.46	19.18	deleterious	0.12	0.4	0.54	disease	0.39	neutral	0.45	neutral	0.5	disease	0	0.99	deleterious	0.5	deleterious	-2	neutral	0.74	deleterious	-3.54	low_impact	1.87	high_impact	0.27	medium_impact	0.42	0.8	0.29	6.81	0.27	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4668	4668	T	C	MI.13173	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	199	67	S	P	Tcc/Ccc	-5.73	0	0	probably_damaging	1	neutral	0.15	neutral	3.77	deleterious	-6.27	deleterious	-4.67	high_impact	4.03	0.85	neutral	0.12	damaging	3.85	23.40	deleterious	0.03	0.35	0.86	disease	0.92	disease	0.79	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	-0.21	medium_impact	2.25	high_impact	0.30	0.8	0.29	6.81	0.46	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4669	4669	C	T	MI.13174	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	200	67	S	F	tCc/tTc	2.79	0.99	0	probably_damaging	1	neutral	0.73	neutral	3.76	deleterious	-7.72	deleterious	-5.6	high_impact	4.03	0.78	neutral	0.09	damaging	4.05	23.70	deleterious	0.03	0.35	0.7	disease	0.94	disease	0.71	disease	0.8	disease	6	1	deleterious	0.37	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.45	medium_impact	2.25	high_impact	0.09	0.8	0.29	6.81	0.45	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4669	4669	C	A	MI.13175	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	200	67	S	Y	tCc/tAc	2.79	0.99	0	probably_damaging	1	neutral	0.75	neutral	3.76	deleterious	-7.44	deleterious	-5.6	high_impact	4.03	0.9	neutral	0.11	damaging	4.03	23.60	deleterious	0.03	0.35	0.77	disease	0.92	disease	0.71	disease	0.74	disease	5	1	deleterious	0.38	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.47	medium_impact	2.25	high_impact	0.25	0.8	0.29	6.81	0.49	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4669	4669	C	G	MI.13176	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	200	67	S	C	tCc/tGc	2.79	0.99	0	probably_damaging	1	neutral	0.13	neutral	3.76	deleterious	-7.76	deleterious	-4.67	high_impact	4.03	0.87	neutral	0.13	damaging	3.42	23.00	deleterious	0.04	0.35	0.83	disease	0.88	disease	0.66	disease	0.69	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.25	medium_impact	2.25	high_impact	0.26	0.8	0.29	6.81	0.57	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4671	4671	A	G	MI.13177	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	202	68	M	V	Ata/Gta	-10.79	0	0	possibly_damaging	0.56	neutral	0.4	neutral	4.81	neutral	1.08	deleterious	-3.51	low_impact	1.19	0.84	neutral	0.17	damaging	2.58	19.95	deleterious	0.31	0.5	0.65	disease	0.81	disease	0.65	disease	0.72	disease	4	0.61	neutral	0.42	neutral	-3	neutral	0.68	deleterious	-0.89	medium_impact	0.11	medium_impact	-0.14	medium_impact	0.36	0.8	1.15	7.52	0.24	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4671	4671	A	C	MI.13178	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	202	68	M	L	Ata/Cta	-10.79	0	0	benign	0.03	neutral	0.41	neutral	4.85	neutral	1.78	deleterious	-2.65	low_impact	1.23	0.92	neutral	0.17	damaging	3.10	22.50	deleterious	0.27	0.45	0.28	neutral	0.85	disease	0.63	disease	0.74	disease	5	0.56	neutral	0.69	deleterious	-6	neutral	0.23	neutral	0.59	medium_impact	0.12	medium_impact	-0.11	medium_impact	0.30	0.8	1.15	7.52	0.3	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4671	4671	A	T	MI.13179	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	202	68	M	L	Ata/Tta	-10.79	0	0	benign	0.03	neutral	0.41	neutral	4.85	neutral	1.78	deleterious	-2.65	low_impact	1.23	0.92	neutral	0.17	damaging	3.24	22.80	deleterious	0.27	0.45	0.28	neutral	0.85	disease	0.63	disease	0.74	disease	5	0.56	neutral	0.69	deleterious	-6	neutral	0.23	neutral	0.59	medium_impact	0.12	medium_impact	-0.11	medium_impact	0.30	0.8	1.15	7.52	0.3	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9145	9145	G	T	MI.1318	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	619	207	A	S	Gcc/Tcc	-3.8	0	0.01	probably_damaging	0.99	neutral	0.09	neutral	4.19	neutral	-1.21	deleterious	-2.65	low_impact	1.9	0.61	neutral	0.6	neutral	3.78	23.40	deleterious	0.36	0.65	NA	NA	0.83	disease	0.41	neutral	0.48	neutral	0	1	deleterious	0.05	neutral	-2	neutral	0.90	deleterious	-2.65	low_impact	-0.28	medium_impact	0.53	medium_impact	0.84	0.9	48.67	8.68	0.36	N	0.95	polymorphism	0.64	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4672	4672	T	A	MI.13180	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	203	68	M	K	aTa/aAa	1.64	0.39	0	probably_damaging	0.93	neutral	0.19	neutral	4.63	neutral	-1.88	deleterious	-5.41	medium_impact	2.82	0.81	neutral	0.13	damaging	3.80	23.40	deleterious	0.04	0.35	0.8	disease	0.93	disease	0.72	disease	0.73	disease	5	0.96	neutral	0.13	neutral	1	deleterious	0.87	deleterious	-1.83	low_impact	-0.14	medium_impact	1.23	medium_impact	0.20	0.8	1.15	7.52	0.3	N	0.98	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4672	4672	T	C	MI.13181	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	203	68	M	T	aTa/aCa	1.64	0.39	0	possibly_damaging	0.85	neutral	0.28	neutral	4.7	neutral	0.41	deleterious	-5.35	neutral_impact	0.42	0.87	neutral	0.31	neutral	2.77	21.20	deleterious	0.15	0.4	0.74	disease	0.55	disease	0.48	neutral	0.3	neutral	4	0.88	neutral	0.22	neutral	-3	neutral	0.76	deleterious	-1.49	low_impact	-0.02	medium_impact	-0.79	medium_impact	0.15	0.8	1.15	7.52	0.35	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4673	4673	A	T	MI.13182	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	204	68	M	I	atA/atT	2.56	0.4	0	possibly_damaging	0.56	neutral	0.37	neutral	4.81	neutral	0.67	deleterious	-3.51	low_impact	0.88	0.9	neutral	0.36	neutral	3.30	22.80	deleterious	0.28	0.45	0.69	disease	0.85	disease	0.58	disease	0.62	disease	2	0.64	neutral	0.41	neutral	-3	neutral	0.71	deleterious	-0.89	medium_impact	0.08	medium_impact	-0.4	medium_impact	0.40	0.8	1.15	7.52	0.42	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4673	4673	A	C	MI.13183	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	204	68	M	I	atA/atC	2.56	0.4	0	possibly_damaging	0.56	neutral	0.37	neutral	4.81	neutral	0.67	deleterious	-3.51	low_impact	0.88	0.9	neutral	0.36	neutral	3.24	22.80	deleterious	0.28	0.45	0.69	disease	0.85	disease	0.58	disease	0.62	disease	2	0.64	neutral	0.41	neutral	-3	neutral	0.71	deleterious	-0.89	medium_impact	0.08	medium_impact	-0.4	medium_impact	0.40	0.8	1.15	7.52	0.41	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4674	4674	A	T	MI.13184	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	205	69	I	F	Atc/Ttc	-1.81	0	0.02	possibly_damaging	0.76	neutral	0.66	neutral	4.66	neutral	0.06	deleterious	-2.67	low_impact	1.62	0.88	neutral	0.5	neutral	3.37	22.90	deleterious	0.19	0.45	0.61	disease	0.72	disease	0.58	disease	0.7	disease	4	0.71	neutral	0.45	neutral	-3	neutral	0.71	deleterious	-1.26	low_impact	0.37	medium_impact	0.22	medium_impact	0.55	0.8	0.58	6.97	0.29	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4674	4674	A	G	MI.13185	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	205	69	I	V	Atc/Gtc	-1.81	0	0.02	benign	0.02	neutral	0.39	neutral	4.57	neutral	-0.08	neutral	-0.88	neutral_impact	0.67	0.99	neutral	0.92	neutral	-0.18	1.21	neutral	0.45	0.55	0.52	disease	0.27	neutral	0.35	neutral	0.32	neutral	4	0.59	neutral	0.69	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.1	medium_impact	-0.58	medium_impact	0.52	0.8	0.58	6.97	0.43	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4674	4674	A	C	MI.13186	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	205	69	I	L	Atc/Ctc	-1.81	0	0.02	benign	0.02	neutral	1	neutral	4.72	neutral	0.73	neutral	0.21	neutral_impact	0.01	0.88	neutral	0.92	neutral	-0.92	0.02	neutral	0.25	0.45	0.41	neutral	0.17	neutral	0.24	neutral	0.28	neutral	4	0.02	neutral	0.99	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	1.87	high_impact	-1.14	low_impact	0.50	0.8	0.58	6.97	0.29	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4675	4675	T	G	MI.13187	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	206	69	I	S	aTc/aGc	-1.58	0	0	possibly_damaging	0.81	neutral	0.56	neutral	4.48	neutral	-2.45	deleterious	-4.51	medium_impact	2.03	0.86	neutral	0.46	neutral	3.79	23.40	deleterious	0.05	0.35	0.63	disease	0.7	disease	0.56	disease	0.69	disease	4	0.78	neutral	0.38	neutral	0	NA	0.70	deleterious	-1.37	low_impact	0.27	medium_impact	0.56	medium_impact	0.34	0.8	0.58	6.97	0.21	N	0.85	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4675	4675	T	A	MI.13188	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	206	69	I	N	aTc/aAc	-1.58	0	0	probably_damaging	0.92	neutral	0.23	neutral	4.45	deleterious	-3.94	deleterious	-5.46	medium_impact	2.27	0.89	neutral	0.44	neutral	4.40	24.10	deleterious	0.14	0.4	0.78	disease	0.78	disease	0.58	disease	0.74	disease	5	0.95	neutral	0.16	neutral	1	deleterious	0.79	deleterious	-1.77	low_impact	-0.08	medium_impact	0.77	medium_impact	0.36	0.8	0.58	6.97	0.4	N	0.89	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4675	4675	T	C	MI.13189	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	206	69	I	T	aTc/aCc	-1.58	0	0	possibly_damaging	0.58	neutral	0.46	neutral	4.49	neutral	-2.12	deleterious	-3.6	neutral_impact	0.78	0.88	neutral	0.78	neutral	1.59	13.81	neutral	0.11	0.4	0.67	disease	0.44	neutral	0.37	neutral	0.59	disease	2	0.58	neutral	0.44	neutral	-3	neutral	0.60	deleterious	-0.93	medium_impact	0.17	medium_impact	-0.49	medium_impact	0.35	0.8	0.58	6.97	0.35	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9145	9145	G	C	MI.1319	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	619	207	A	P	Gcc/Ccc	-3.8	0	0.01	probably_damaging	1	deleterious	0.01	neutral	4.04	deleterious	-4.4	deleterious	-4.49	high_impact	4.32	0.42	damaging	0.44	neutral	3.91	23.50	deleterious	0.12	0.65	NA	NA	0.94	disease	0.75	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.94	deleterious	-3.6	low_impact	-0.84	medium_impact	2.6	high_impact	0.74	0.9	48.67	8.68	0.57	P	0.97	disease_causing	0.82	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4676	4676	C	A	MI.13190	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	207	69	I	M	atC/atA	3.25	0.17	0	possibly_damaging	0.86	neutral	0.73	neutral	4.5	neutral	-1.7	neutral	-1.03	neutral_impact	0.72	0.88	neutral	0.95	neutral	2.16	17.24	deleterious	0.36	0.5	0.59	disease	0.27	neutral	0.28	neutral	0.55	disease	1	0.83	neutral	0.44	neutral	-3	neutral	0.66	deleterious	-1.52	low_impact	0.45	medium_impact	-0.54	medium_impact	0.58	0.8	0.58	6.97	0.33	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4676	4676	C	G	MI.13191	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	207	69	I	M	atC/atG	3.25	0.17	0	possibly_damaging	0.86	neutral	0.73	neutral	4.5	neutral	-1.7	neutral	-1.03	neutral_impact	0.72	0.88	neutral	0.95	neutral	1.69	14.36	neutral	0.36	0.5	0.59	disease	0.27	neutral	0.28	neutral	0.55	disease	1	0.83	neutral	0.44	neutral	-3	neutral	0.66	deleterious	-1.52	low_impact	0.45	medium_impact	-0.54	medium_impact	0.58	0.8	0.58	6.97	0.33	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4677	4677	C	A	MI.13192	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	208	70	L	I	Ctt/Att	-2.73	0	0	possibly_damaging	0.56	neutral	0.64	neutral	3.82	neutral	-2.77	neutral	-1.85	neutral_impact	0.52	0.9	neutral	0.88	neutral	1.00	10.64	neutral	0.2	0.45	NA	NA	0.25	neutral	0.25	neutral	0.19	neutral	6	0.49	neutral	0.54	deleterious	-3	neutral	0.61	deleterious	-0.89	medium_impact	0.35	medium_impact	-0.71	medium_impact	0.45	0.8	0.29	6.59	0.38	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4677	4677	C	T	MI.13193	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	208	70	L	F	Ctt/Ttt	-2.73	0	0	benign	0.06	neutral	0.28	neutral	3.77	deleterious	-3.15	deleterious	-3.57	low_impact	0.98	0.99	neutral	0.8	neutral	0.73	9.04	deleterious	0.13	0.4	NA	NA	0.76	disease	0.39	neutral	0.41	neutral	2	0.69	neutral	0.61	deleterious	-6	neutral	0.26	neutral	0.3	medium_impact	-0.02	medium_impact	-0.32	medium_impact	0.34	0.8	0.29	6.59	0.45	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4677	4677	C	G	MI.13194	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	208	70	L	V	Ctt/Gtt	-2.73	0	0	possibly_damaging	0.56	neutral	0.12	neutral	3.7	deleterious	-3.97	deleterious	-2.8	low_impact	1.6	0.89	neutral	0.75	neutral	0.48	7.31	deleterious	0.15	0.4	NA	NA	0.37	neutral	0.36	neutral	0.16	neutral	7	0.88	neutral	0.28	neutral	-3	neutral	0.64	deleterious	-0.89	medium_impact	-0.27	medium_impact	0.2	medium_impact	0.54	0.8	0.29	6.59	0.53	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4678	4678	T	C	MI.13195	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	209	70	L	P	cTt/cCt	-2.5	0	0	probably_damaging	0.97	deleterious	0.02	neutral	3.61	deleterious	-8.26	deleterious	-6.58	high_impact	3.5	0.83	neutral	0.34	neutral	3.65	23.20	deleterious	0.01	0.35	NA	NA	0.92	disease	0.7	disease	0.75	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.90	deleterious	-2.18	low_impact	-0.73	medium_impact	1.8	medium_impact	0.33	0.8	0.29	6.59	0.38	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4678	4678	T	A	MI.13196	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	209	70	L	H	cTt/cAt	-2.5	0	0	probably_damaging	0.97	neutral	0.05	neutral	3.61	deleterious	-8.63	deleterious	-6.51	high_impact	3.5	0.86	neutral	0.43	neutral	3.91	23.50	deleterious	0.03	0.35	NA	NA	0.85	disease	0.67	disease	0.73	disease	5	0.99	deleterious	0.04	neutral	2	deleterious	0.83	deleterious	-2.18	low_impact	-0.5	medium_impact	1.8	medium_impact	0.23	0.8	0.29	6.59	0.41	N	0.85	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4678	4678	T	G	MI.13197	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	209	70	L	R	cTt/cGt	-2.5	0	0	probably_damaging	0.93	neutral	0.07	neutral	3.62	deleterious	-7.9	deleterious	-5.63	high_impact	3.5	0.83	neutral	0.4	neutral	3.97	23.60	deleterious	0.01	0.35	NA	NA	0.94	disease	0.7	disease	0.82	disease	6	0.98	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-1.83	low_impact	-0.42	medium_impact	1.8	medium_impact	0.14	0.8	0.29	6.59	0.39	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4680	4680	C	A	MI.13198	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	211	71	L	M	Cta/Ata	-11.71	0	0	benign	0.07	neutral	0.2	neutral	3.57	deleterious	-3.95	neutral	1.99	neutral_impact	0.78	0.88	neutral	0.86	neutral	-1.01	0.02	neutral	0.1	0.4	NA	NA	0.25	neutral	0.41	neutral	0.16	neutral	7	0.78	neutral	0.57	deleterious	-6	neutral	0.26	neutral	0.23	medium_impact	-0.13	medium_impact	-0.49	medium_impact	0.48	0.8	0.58	7.58	0.42	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4680	4680	C	G	MI.13199	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	211	71	L	V	Cta/Gta	-11.71	0	0	benign	0.22	neutral	0.06	neutral	3.54	deleterious	-4.28	neutral	-1.26	medium_impact	2.42	0.92	neutral	0.61	neutral	1.45	13.03	neutral	0.08	0.35	NA	NA	0.69	disease	0.61	disease	0.57	disease	1	0.93	neutral	0.42	neutral	-3	neutral	0.53	deleterious	-0.29	medium_impact	-0.46	medium_impact	0.89	medium_impact	0.50	0.8	0.58	7.58	0.39	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8588	8588	T	C	MI.132	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	62	21	V	A	gTa/gCa	-2.42	0	0	benign	0.39	neutral	0.49	neutral	4.31	neutral	-0.84	neutral	-0.85	neutral_impact	-1.51	0.89	neutral	0.73	neutral	-0.21	1.05	neutral	0.35	0.65	0.44	neutral	0.06	neutral	0.26	neutral	0.25	neutral	5	0.44	neutral	0.55	deleterious	-6	neutral	0.38	neutral	-0.57	medium_impact	0.28	medium_impact	-2.39	low_impact	0.34	0.9	22.57	20.88	0.42	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9146	9146	C	G	MI.1320	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	620	207	A	G	gCc/gGc	7.3	1	0	probably_damaging	0.99	neutral	0.05	neutral	4.19	neutral	-1.21	deleterious	-3.57	medium_impact	2.77	0.66	neutral	0.59	neutral	4.10	23.70	deleterious	0.35	0.65	NA	NA	0.89	disease	0.53	disease	0.71	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.88	deleterious	-2.65	low_impact	-0.43	medium_impact	1.28	medium_impact	0.82	0.9	48.67	8.68	0.5	P	0.86	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4681	4681	T	A	MI.13200	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	212	71	L	Q	cTa/cAa	-0.66	0	0	possibly_damaging	0.86	deleterious	0.04	neutral	3.46	deleterious	-7.75	deleterious	-2.56	medium_impact	3.46	0.83	neutral	0.51	neutral	3.62	23.20	deleterious	0.02	0.35	NA	NA	0.87	disease	0.67	disease	0.72	disease	4	0.98	neutral	0.09	neutral	4	deleterious	0.81	deleterious	-1.52	low_impact	-0.56	medium_impact	1.77	medium_impact	0.22	0.8	0.58	7.58	0.44	N	0.85	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4681	4681	T	C	MI.13201	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	212	71	L	P	cTa/cCa	-0.66	0	0	probably_damaging	0.92	deleterious	0.04	neutral	3.46	deleterious	-8.21	deleterious	-4.27	medium_impact	3.46	0.74	neutral	0.4	neutral	3.61	23.20	deleterious	0.02	0.35	NA	NA	0.91	disease	0.76	disease	0.76	disease	5	0.99	deleterious	0.06	neutral	5	deleterious	0.89	deleterious	-1.77	low_impact	-0.56	medium_impact	1.77	medium_impact	0.26	0.8	0.58	7.58	0.52	N	0.98	disease_causing_automatic	0	0.30	rs267606889	Pathogenic	Leigh_syndrome|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency	24760	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838951	.	.	.	.	T4681C	Leigh Syndrome	-	+	Reported	2	P	P	P	damaging
chrM	4681	4681	T	G	MI.13202	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	212	71	L	R	cTa/cGa	-0.66	0	0	possibly_damaging	0.86	deleterious	0.02	neutral	3.46	deleterious	-7.78	deleterious	-3.33	medium_impact	3.12	0.83	neutral	0.42	neutral	3.74	23.30	deleterious	0.02	0.35	NA	NA	0.94	disease	0.77	disease	0.84	disease	7	0.99	deleterious	0.08	neutral	4	deleterious	0.88	deleterious	-1.52	low_impact	-0.73	medium_impact	1.48	medium_impact	0.16	0.8	0.58	7.58	0.45	N	0.88	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4683	4683	A	T	MI.13203	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	214	72	M	L	Ata/Tta	-0.2	0	0	benign	0.01	neutral	0.75	neutral	4.88	neutral	1.19	neutral	-0.52	neutral_impact	-0.32	0.95	neutral	0.97	neutral	0.47	7.22	deleterious	0.21	0.45	NA	NA	0.6	disease	0.41	neutral	0.21	neutral	6	0.22	neutral	0.87	deleterious	-6	neutral	0.22	neutral	1.03	medium_impact	0.47	medium_impact	-1.41	low_impact	0.23	0.8	0.86	7.78	0.22	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4683	4683	A	C	MI.13204	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	214	72	M	L	Ata/Cta	-0.2	0	0	benign	0.01	neutral	0.75	neutral	4.88	neutral	1.19	neutral	-0.52	neutral_impact	-0.32	0.95	neutral	0.97	neutral	0.37	6.34	deleterious	0.21	0.45	NA	NA	0.6	disease	0.41	neutral	0.21	neutral	6	0.22	neutral	0.87	deleterious	-6	neutral	0.22	neutral	1.03	medium_impact	0.47	medium_impact	-1.41	low_impact	0.23	0.8	0.86	7.78	0.22	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4683	4683	A	G	MI.13205	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	214	72	M	V	Ata/Gta	-0.2	0	0	benign	0.34	neutral	0.29	neutral	4.75	neutral	0.5	neutral	-2.16	low_impact	1.19	0.92	neutral	0.75	neutral	1.51	13.38	neutral	0.19	0.45	NA	NA	0.74	disease	0.59	disease	0.7	disease	4	0.65	neutral	0.48	deleterious	-6	neutral	0.55	deleterious	-0.53	medium_impact	-0.01	medium_impact	-0.14	medium_impact	0.26	0.8	0.86	7.78	0.33	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4684	4684	T	C	MI.13206	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	215	72	M	T	aTa/aCa	-0.89	0	0	possibly_damaging	0.62	neutral	0.13	neutral	4.64	neutral	-0.92	deleterious	-3.81	low_impact	1.26	0.89	neutral	0.57	neutral	2.83	21.50	deleterious	0.1	0.4	NA	NA	0.71	disease	0.59	disease	0.69	disease	4	0.87	neutral	0.26	neutral	-3	neutral	0.73	deleterious	-0.99	medium_impact	-0.25	medium_impact	-0.08	medium_impact	0.18	0.8	0.86	7.78	0.43	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4684	4684	T	A	MI.13207	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	215	72	M	K	aTa/aAa	-0.89	0	0	possibly_damaging	0.79	neutral	0.12	neutral	4.6	neutral	-2.71	deleterious	-4.44	medium_impact	2.5	0.83	neutral	0.41	neutral	4.09	23.70	deleterious	0.03	0.35	NA	NA	0.89	disease	0.67	disease	0.79	disease	6	0.92	neutral	0.17	neutral	0	NA	0.80	deleterious	-1.32	low_impact	-0.27	medium_impact	0.96	medium_impact	0.18	0.8	0.86	7.78	0.35	N	0.87	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4685	4685	A	C	MI.13208	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	216	72	M	I	atA/atC	5.55	0.87	0	benign	0.34	neutral	0.36	neutral	4.73	neutral	0.14	neutral	-1.78	low_impact	0.88	0.84	neutral	0.37	neutral	3.18	22.70	deleterious	0.2	0.45	NA	NA	0.82	disease	0.59	disease	0.74	disease	5	0.57	neutral	0.51	deleterious	-6	neutral	0.60	deleterious	-0.53	medium_impact	0.07	medium_impact	-0.4	medium_impact	0.28	0.8	0.86	7.78	0.41	N	0.57	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4685	4685	A	T	MI.13209	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	216	72	M	I	atA/atT	5.55	0.87	0	benign	0.34	neutral	0.36	neutral	4.73	neutral	0.14	neutral	-1.78	low_impact	0.88	0.84	neutral	0.37	neutral	3.35	22.90	deleterious	0.2	0.45	NA	NA	0.82	disease	0.59	disease	0.74	disease	5	0.57	neutral	0.51	deleterious	-6	neutral	0.60	deleterious	-0.53	medium_impact	0.07	medium_impact	-0.4	medium_impact	0.28	0.8	0.86	7.78	0.41	N	0.57	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9146	9146	C	T	MI.1321	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	620	207	A	V	gCc/gTc	7.3	1	0	probably_damaging	1	neutral	0.05	neutral	4.1	neutral	-2.29	deleterious	-3.58	high_impact	3.77	0.45	damaging	0.44	neutral	4.64	24.50	deleterious	0.41	0.65	NA	NA	0.91	disease	0.65	disease	0.72	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.43	medium_impact	2.13	high_impact	0.83	0.9	48.67	8.68	0.66	P	0.75	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4686	4686	G	T	MI.13210	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	217	73	A	S	Gct/Tct	-2.04	0	0	possibly_damaging	0.87	neutral	0.53	neutral	4.51	neutral	-1.58	neutral	-2.31	neutral_impact	0.7	0.82	neutral	0.87	neutral	2.07	16.69	deleterious	0.22	0.45	NA	NA	0.27	neutral	0.29	neutral	0.19	neutral	6	0.85	neutral	0.33	neutral	-3	neutral	0.70	deleterious	-1.55	low_impact	0.24	medium_impact	-0.56	medium_impact	0.55	0.8	0.58	7.45	0.33	N	0.29	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4686	4686	G	A	MI.13211	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	217	73	A	T	Gct/Act	-2.04	0	0	benign	0.36	neutral	0.41	neutral	4.45	neutral	-2.96	deleterious	-3.14	medium_impact	2.21	0.89	neutral	0.46	neutral	2.97	22.10	deleterious	0.11	0.4	NA	NA	0.83	disease	0.41	neutral	0.49	neutral	0	0.52	neutral	0.53	deleterious	-3	neutral	0.62	deleterious	-0.57	medium_impact	0.12	medium_impact	0.72	medium_impact	0.72	0.85	0.58	7.45	0.36	N	0.42	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4686	4686	G	C	MI.13212	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	217	73	A	P	Gct/Cct	-2.04	0	0	probably_damaging	0.99	neutral	0.22	neutral	4.4	deleterious	-4.33	deleterious	-4.24	medium_impact	3.17	0.76	neutral	0.09	damaging	3.65	23.20	deleterious	0.03	0.35	NA	NA	0.96	disease	0.73	disease	0.83	disease	7	0.99	deleterious	0.12	neutral	1	deleterious	0.91	deleterious	-2.62	low_impact	-0.1	medium_impact	1.52	medium_impact	0.52	0.8	0.58	7.45	0.29	N	0.87	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4687	4687	C	A	MI.13213	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	218	73	A	D	gCt/gAt	0.03	0	0	probably_damaging	0.98	neutral	0.2	neutral	4.41	deleterious	-3.95	deleterious	-4.93	high_impact	3.52	0.83	neutral	0.09	damaging	4.42	24.20	deleterious	0.02	0.35	NA	NA	0.95	disease	0.72	disease	0.83	disease	6	0.99	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-2.34	low_impact	-0.13	medium_impact	1.82	medium_impact	0.28	0.8	0.58	7.45	0.32	N	0.88	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4687	4687	C	G	MI.13214	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	218	73	A	G	gCt/gGt	0.03	0	0	probably_damaging	0.93	neutral	0.44	neutral	4.66	neutral	0.55	deleterious	-2.73	low_impact	1.14	0.9	neutral	0.83	neutral	2.52	19.60	deleterious	0.23	0.45	NA	NA	0.8	disease	0.38	neutral	0.19	neutral	6	0.93	neutral	0.26	neutral	-2	neutral	0.79	deleterious	-1.83	low_impact	0.15	medium_impact	-0.19	medium_impact	0.68	0.85	0.58	7.45	0.3	N	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4687	4687	C	T	MI.13215	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	218	73	A	V	gCt/gTt	0.03	0	0	possibly_damaging	0.87	neutral	0.53	neutral	4.5	neutral	-2.79	deleterious	-3.49	medium_impact	2.72	0.88	neutral	0.26	damaging	4.21	23.90	deleterious	0.08	0.35	NA	NA	0.89	disease	0.61	disease	0.73	disease	5	0.85	neutral	0.33	neutral	0	NA	0.82	deleterious	-1.55	low_impact	0.24	medium_impact	1.15	medium_impact	0.70	0.85	0.58	7.45	0.35	N	0.46	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4689	4689	A	G	MI.13216	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	220	74	I	V	Atc/Gtc	-14.94	0	0	probably_damaging	0.99	neutral	0.51	neutral	4.47	neutral	-1.41	neutral	-0.36	neutral_impact	0.55	0.91	neutral	0.93	neutral	1.48	13.22	neutral	0.49	0.55	NA	NA	0.33	neutral	0.29	neutral	0.16	neutral	7	0.99	deleterious	0.26	neutral	-2	neutral	0.70	deleterious	-2.62	low_impact	0.22	medium_impact	-0.68	medium_impact	0.40	0.8	0.86	8.3	0.39	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4689	4689	A	C	MI.13217	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	220	74	I	L	Atc/Ctc	-14.94	0	0	probably_damaging	0.99	neutral	0.66	neutral	4.48	neutral	-0.57	neutral	-1.56	low_impact	1.45	0.91	neutral	0.54	neutral	3.63	23.20	deleterious	0.28	0.45	NA	NA	0.61	disease	0.41	neutral	0.46	neutral	1	0.99	deleterious	0.34	neutral	-2	neutral	0.74	deleterious	-2.62	low_impact	0.37	medium_impact	0.08	medium_impact	0.46	0.8	0.86	8.3	0.28	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4689	4689	A	T	MI.13218	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	220	74	I	F	Atc/Ttc	-14.94	0	0	probably_damaging	1	neutral	0.71	neutral	4.42	neutral	-2.31	deleterious	-3.33	low_impact	1.59	0.9	neutral	0.18	damaging	3.75	23.30	deleterious	0.19	0.45	NA	NA	0.75	disease	0.5	neutral	0.5	disease	0	1	deleterious	0.36	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	0.42	medium_impact	0.19	medium_impact	0.51	0.8	0.86	8.3	0.25	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4690	4690	T	A	MI.13219	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	221	74	I	N	aTc/aAc	-0.43	0	0	probably_damaging	1	neutral	0.31	neutral	4.32	deleterious	-4.75	deleterious	-5.49	medium_impact	2.29	0.82	neutral	0.13	damaging	4.27	23.90	deleterious	0.08	0.35	NA	NA	0.79	disease	0.49	neutral	0.59	disease	2	1	deleterious	0.16	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.02	medium_impact	0.78	medium_impact	0.32	0.8	0.86	8.3	0.26	N	0.98	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9146	9146	C	A	MI.1322	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	620	207	A	D	gCc/gAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	4.05	deleterious	-4.01	deleterious	-5.34	high_impact	4.32	0.55	damaging	0.49	neutral	4.68	24.50	deleterious	0.15	0.65	NA	NA	0.96	disease	0.73	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.6	low_impact	-1.4	low_impact	2.6	high_impact	0.67	0.9	48.67	8.68	0.5	N	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4690	4690	T	G	MI.13220	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	221	74	I	S	aTc/aGc	-0.43	0	0	probably_damaging	1	neutral	0.43	neutral	4.36	deleterious	-3.09	deleterious	-4.26	neutral_impact	0.01	0.8	neutral	0.34	neutral	2.89	21.80	deleterious	0.05	0.35	NA	NA	0.24	neutral	0.3	neutral	0.17	neutral	7	1	deleterious	0.22	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.14	medium_impact	-1.14	low_impact	0.33	0.8	0.86	8.3	0.27	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4690	4690	T	C	MI.13221	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	221	74	I	T	aTc/aCc	-0.43	0	0	probably_damaging	1	neutral	0.4	neutral	4.35	neutral	-2.96	deleterious	-3.3	low_impact	1.04	0.88	neutral	0.66	neutral	2.17	17.32	deleterious	0.1	0.4	NA	NA	0.48	neutral	0.29	neutral	0.19	neutral	6	1	deleterious	0.2	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.11	medium_impact	-0.27	medium_impact	0.32	0.8	0.86	8.3	0.34	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4691	4691	C	A	MI.13222	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	222	74	I	M	atC/atA	0.03	0	0	probably_damaging	1	neutral	0.22	neutral	4.43	neutral	-2.12	neutral	-2.23	low_impact	1.31	0.85	neutral	0.13	damaging	3.74	23.30	deleterious	0.32	0.5	NA	NA	0.58	disease	0.37	neutral	0.45	neutral	1	1	deleterious	0.11	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	-0.1	medium_impact	-0.04	medium_impact	0.50	0.8	0.86	8.3	0.3	N	0.65	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4691	4691	C	G	MI.13223	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	222	74	I	M	atC/atG	0.03	0	0	probably_damaging	1	neutral	0.22	neutral	4.43	neutral	-2.12	neutral	-2.23	low_impact	1.31	0.85	neutral	0.13	damaging	3.27	22.80	deleterious	0.32	0.5	NA	NA	0.58	disease	0.37	neutral	0.45	neutral	1	1	deleterious	0.11	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	-0.1	medium_impact	-0.04	medium_impact	0.50	0.8	0.86	8.3	0.3	N	0.65	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4692	4692	C	A	MI.13224	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	223	75	L	I	Ctc/Atc	-7.34	0	0	benign	0.01	neutral	1	neutral	4.53	neutral	-0.71	neutral	0.79	neutral_impact	-0.69	0.92	neutral	0.92	neutral	1.23	11.89	neutral	0.36	0.5	NA	NA	0.33	neutral	0.19	neutral	0.15	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	1.87	high_impact	-1.73	low_impact	0.52	0.8	2.59	7.65	0.27	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4692	4692	C	T	MI.13225	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	223	75	L	F	Ctc/Ttc	-7.34	0	0	benign	0.01	neutral	0.5	neutral	4.45	neutral	-1.46	neutral	-1.86	low_impact	0.98	0.88	neutral	0.82	neutral	3.83	23.40	deleterious	0.24	0.45	NA	NA	0.64	disease	0.44	neutral	0.43	neutral	1	0.49	neutral	0.75	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.21	medium_impact	-0.32	medium_impact	0.48	0.8	2.59	7.65	0.28	N	0.19	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4692	4692	C	G	MI.13226	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	223	75	L	V	Ctc/Gtc	-7.34	0	0	benign	0.02	neutral	0.45	neutral	4.45	neutral	-1.42	neutral	0.49	neutral_impact	0.44	0.92	neutral	0.97	neutral	1.96	15.99	deleterious	0.37	0.5	NA	NA	0.47	neutral	0.25	neutral	0.19	neutral	6	0.53	neutral	0.72	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	0.16	medium_impact	-0.77	medium_impact	0.64	0.8	2.59	7.65	0.39	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4693	4693	T	G	MI.13227	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	224	75	L	R	cTc/cGc	-0.43	0	0	possibly_damaging	0.56	neutral	0.2	neutral	4.35	deleterious	-3.86	deleterious	-3.72	medium_impact	2.33	0.84	neutral	0.47	neutral	4.07	23.70	deleterious	0.02	0.35	NA	NA	0.9	disease	0.66	disease	0.78	disease	6	0.79	neutral	0.32	neutral	0	NA	0.77	deleterious	-0.89	medium_impact	-0.13	medium_impact	0.82	medium_impact	0.21	0.8	2.59	7.65	0.33	N	0.71	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4693	4693	T	A	MI.13228	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	224	75	L	H	cTc/cAc	-0.43	0	0	possibly_damaging	0.74	neutral	0.28	neutral	4.35	deleterious	-4.42	deleterious	-4	medium_impact	2.33	0.85	neutral	0.51	neutral	3.98	23.60	deleterious	0.04	0.35	NA	NA	0.7	disease	0.63	disease	0.71	disease	4	0.81	neutral	0.27	neutral	0	NA	0.66	deleterious	-1.21	low_impact	-0.02	medium_impact	0.82	medium_impact	0.22	0.8	2.59	7.65	0.32	N	0.70	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4693	4693	T	C	MI.13229	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	224	75	L	P	cTc/cCc	-0.43	0	0	possibly_damaging	0.74	neutral	0.11	neutral	4.34	deleterious	-4.47	deleterious	-3.83	low_impact	1.78	0.73	neutral	0.41	neutral	3.75	23.30	deleterious	0.02	0.35	NA	NA	0.9	disease	0.61	disease	0.76	disease	5	0.92	neutral	0.19	neutral	-3	neutral	0.77	deleterious	-1.21	low_impact	-0.3	medium_impact	0.35	medium_impact	0.25	0.8	2.59	7.65	0.32	N	0.84	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9148	9148	T	A	MI.1323	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	622	208	L	M	Tta/Ata	-9.13	0	0.01	probably_damaging	1	neutral	1	neutral	4.36	neutral	-0.94	neutral	0.11	neutral_impact	-0.18	0.84	neutral	0.85	neutral	1.00	10.67	neutral	0.3	0.65	NA	NA	0.05	neutral	0.23	neutral	0.17	neutral	7	1	deleterious	0.5	deleterious	-2	neutral	0.71	deleterious	-3.6	low_impact	1.98	high_impact	-1.25	low_impact	0.73	0.9	NA	NA	0.3	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4695	4695	T	A	MI.13230	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	226	76	F	I	Ttc/Atc	-9.41	0	0	benign	0	neutral	1	neutral	4.78	neutral	-1.31	neutral	2.75	neutral_impact	-1.75	0.89	neutral	0.93	neutral	-0.41	0.38	neutral	0.23	0.45	0.55	disease	0.32	neutral	0.22	neutral	0.6	disease	2	0	neutral	1	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	1.87	high_impact	-2.62	low_impact	0.47	0.8	2.59	8.22	0.27	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4695	4695	T	C	MI.13231	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	226	76	F	L	Ttc/Ctc	-9.41	0	0	benign	0	neutral	0.84	neutral	4.83	neutral	0.23	neutral	1.93	neutral_impact	-0.78	0.96	neutral	0.97	neutral	0.23	5.00	deleterious	0.26	0.45	0.35	neutral	0.49	neutral	0.31	neutral	0.28	neutral	5	0.16	neutral	0.92	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.61	medium_impact	-1.8	low_impact	0.67	0.85	2.59	8.22	0.22	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4695	4695	T	G	MI.13232	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	226	76	F	V	Ttc/Gtc	-9.41	0	0	benign	0	neutral	0.45	neutral	4.77	neutral	-1.18	neutral	2.01	neutral_impact	0.02	0.91	neutral	0.82	neutral	0.86	9.86	deleterious	0.15	0.4	0.63	disease	0.61	disease	0.33	neutral	0.27	neutral	5	0.55	neutral	0.73	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	0.16	medium_impact	-1.13	low_impact	0.40	0.8	2.59	8.22	0.3	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4696	4696	T	C	MI.13233	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	227	76	F	S	tTc/tCc	-0.89	0	0	benign	0	neutral	0.59	neutral	4.66	neutral	-2.73	neutral	-1.82	neutral_impact	-0.15	0.93	neutral	0.92	neutral	0.88	9.95	deleterious	0.07	0.35	0.68	disease	0.53	disease	0.36	neutral	0.28	neutral	4	0.41	neutral	0.8	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	0.3	medium_impact	-1.27	low_impact	0.27	0.8	2.59	8.22	0.27	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4696	4696	T	A	MI.13234	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	227	76	F	Y	tTc/tAc	-0.89	0	0	benign	0	neutral	0.43	neutral	4.75	neutral	-0.17	neutral	-0.86	neutral_impact	0.12	0.98	neutral	0.9	neutral	0.69	8.77	deleterious	0.24	0.45	0.31	neutral	0.49	neutral	0.31	neutral	0.34	neutral	3	0.57	neutral	0.72	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.14	medium_impact	-1.04	low_impact	0.62	0.8	2.59	8.22	0.37	N	0.03	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4696	4696	T	G	MI.13235	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	227	76	F	C	tTc/tGc	-0.89	0	0	benign	0	neutral	0.12	neutral	4.62	deleterious	-4	neutral	-1.1	low_impact	1.15	0.92	neutral	0.58	neutral	1.99	16.17	deleterious	0.07	0.35	0.89	disease	0.76	disease	0.54	disease	0.68	disease	4	0.88	neutral	0.56	deleterious	-6	neutral	0.24	neutral	1.95	medium_impact	-0.27	medium_impact	-0.18	medium_impact	0.20	0.8	2.59	8.22	0.36	N	0.12	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4697	4697	C	A	MI.13236	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	228	76	F	L	ttC/ttA	-0.66	0	0	benign	0	neutral	0.84	neutral	4.83	neutral	0.23	neutral	1.93	neutral_impact	-0.78	0.96	neutral	0.97	neutral	0.89	10.02	neutral	0.26	0.45	0.35	neutral	0.49	neutral	0.31	neutral	0.28	neutral	5	0.16	neutral	0.92	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.61	medium_impact	-1.8	low_impact	0.67	0.85	2.59	8.22	0.21	N	0.06	polymorphism	1	0.01	rs386828948	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4697	4697	C	G	MI.13237	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	228	76	F	L	ttC/ttG	-0.66	0	0	benign	0	neutral	0.84	neutral	4.83	neutral	0.23	neutral	1.93	neutral_impact	-0.78	0.96	neutral	0.97	neutral	0.58	7.99	deleterious	0.26	0.45	0.35	neutral	0.49	neutral	0.31	neutral	0.28	neutral	5	0.16	neutral	0.92	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.61	medium_impact	-1.8	low_impact	0.67	0.85	2.59	8.22	0.22	N	0.06	polymorphism	1	0.01	rs386828948	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4698	4698	A	C	MI.13238	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	229	77	N	H	Aac/Cac	-5.73	0	0	probably_damaging	1	neutral	0.54	neutral	4.62	neutral	-1.25	deleterious	-4.81	high_impact	3.52	0.83	neutral	0.3	neutral	2.93	22.00	deleterious	0.31	0.45	0.81	disease	0.87	disease	0.77	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.25	medium_impact	1.82	medium_impact	0.24	0.8	0.58	8.65	0.29	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4698	4698	A	T	MI.13239	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	229	77	N	Y	Aac/Tac	-5.73	0	0	probably_damaging	1	neutral	1	neutral	4.67	neutral	0.65	deleterious	-7.44	medium_impact	2.55	0.8	neutral	0.34	neutral	3.56	23.10	deleterious	0.07	0.35	0.87	disease	0.9	disease	0.71	disease	0.66	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.84	deleterious	-3.54	low_impact	1.87	high_impact	1	medium_impact	0.23	0.8	0.58	8.65	0.19	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9148	9148	T	G	MI.1324	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	622	208	L	V	Tta/Gta	-9.13	0	0.01	probably_damaging	0.99	neutral	0.53	neutral	4.37	neutral	0.14	neutral	-1.84	neutral_impact	0.76	0.86	neutral	0.78	neutral	3.44	23.00	deleterious	0.31	0.65	NA	NA	0.44	neutral	0.31	neutral	0.21	neutral	6	0.99	deleterious	0.27	neutral	-2	neutral	0.79	deleterious	-2.65	low_impact	0.32	medium_impact	-0.45	medium_impact	0.50	0.9	NA	NA	0.29	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4698	4698	A	G	MI.13240	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	229	77	N	D	Aac/Gac	-5.73	0	0	probably_damaging	1	neutral	0.21	neutral	4.62	neutral	-1.83	deleterious	-4.81	medium_impact	3.32	0.86	neutral	0.52	neutral	3.65	23.20	deleterious	0.36	0.5	0.65	disease	0.83	disease	0.68	disease	0.69	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.11	medium_impact	1.65	medium_impact	0.34	0.8	0.58	8.65	0.32	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4699	4699	A	C	MI.13241	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	230	77	N	T	aAc/aCc	6.71	1	0	probably_damaging	1	neutral	0.39	neutral	4.68	neutral	1.02	deleterious	-5.73	medium_impact	2.67	0.89	neutral	0.48	neutral	3.19	22.70	deleterious	0.21	0.45	0.59	disease	0.87	disease	0.56	disease	0.66	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.1	medium_impact	1.1	medium_impact	0.37	0.8	0.58	8.65	0.58	P	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4699	4699	A	T	MI.13242	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	230	77	N	I	aAc/aTc	6.71	1	0	probably_damaging	1	neutral	0.4	neutral	4.9	neutral	3.08	deleterious	-8.06	medium_impact	2.83	0.83	neutral	0.55	neutral	3.87	23.50	deleterious	0.11	0.4	0.84	disease	0.95	disease	0.64	disease	0.68	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.11	medium_impact	1.24	medium_impact	0.19	0.8	0.58	8.65	0.58	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4699	4699	A	G	MI.13243	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	230	77	N	S	aAc/aGc	6.71	1	0	probably_damaging	1	neutral	0.41	neutral	4.67	neutral	0.77	deleterious	-4.79	medium_impact	2.1	0.83	neutral	0.6	neutral	2.93	22.00	deleterious	0.37	0.5	0.52	disease	0.82	disease	0.66	disease	0.68	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.12	medium_impact	0.62	medium_impact	0.44	0.8	0.58	8.65	0.56	P	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4700	4700	C	G	MI.13244	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	231	77	N	K	aaC/aaG	4.4	1	0	probably_damaging	1	neutral	0.29	neutral	4.63	neutral	-0.65	deleterious	-5.74	medium_impact	3.06	0.78	neutral	0.35	neutral	3.79	23.40	deleterious	0.24	0.45	0.54	disease	0.91	disease	0.71	disease	0.73	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.01	medium_impact	1.43	medium_impact	0.58	0.8	0.58	8.65	0.52	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4700	4700	C	A	MI.13245	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	231	77	N	K	aaC/aaA	4.4	1	0	probably_damaging	1	neutral	0.29	neutral	4.63	neutral	-0.65	deleterious	-5.74	medium_impact	3.06	0.78	neutral	0.35	neutral	4.27	23.90	deleterious	0.24	0.45	0.54	disease	0.91	disease	0.71	disease	0.73	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.01	medium_impact	1.43	medium_impact	0.58	0.8	0.58	8.65	0.52	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4701	4701	A	C	MI.13246	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	232	78	N	H	Aat/Cat	-2.96	0	0	possibly_damaging	0.52	neutral	0.54	neutral	4.66	neutral	0.72	neutral	-0.24	low_impact	1.28	0.88	neutral	0.75	neutral	1.64	14.09	neutral	0.35	0.5	0.57	disease	0.52	disease	0.43	neutral	0.42	neutral	2	0.49	neutral	0.51	deleterious	-3	neutral	0.69	deleterious	-0.83	medium_impact	0.25	medium_impact	-0.07	medium_impact	0.29	0.8	15.27	10.16	0.29	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4701	4701	A	T	MI.13247	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	232	78	N	Y	Aat/Tat	-2.96	0	0	benign	0.02	neutral	1	neutral	5.01	neutral	4.51	neutral	1.32	neutral_impact	-0.38	0.92	neutral	0.89	neutral	1.85	15.27	deleterious	0.11	0.4	0.39	neutral	0.65	disease	0.25	neutral	0.36	neutral	3	0.02	neutral	0.99	deleterious	-6	neutral	0.25	neutral	0.75	medium_impact	1.87	high_impact	-1.46	low_impact	0.21	0.8	15.27	10.16	0.23	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4701	4701	A	G	MI.13248	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	232	78	N	D	Aat/Gat	-2.96	0	0	benign	0.13	neutral	0.23	neutral	4.64	neutral	-0.87	neutral	-1.16	low_impact	0.94	0.85	neutral	0.49	neutral	3.46	23.00	deleterious	0.52	0.6	0.38	neutral	0.59	disease	0.53	disease	0.57	disease	1	0.74	neutral	0.55	deleterious	-6	neutral	0.62	deleterious	-0.04	medium_impact	-0.08	medium_impact	-0.35	medium_impact	0.41	0.8	15.27	10.16	0.34	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4702	4702	A	T	MI.13249	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	233	78	N	I	aAt/aTt	-0.2	0	0	benign	0.37	neutral	0.41	neutral	4.73	neutral	2.5	neutral	2.61	neutral_impact	-0.1	0.9	neutral	0.65	neutral	2.76	21.20	deleterious	0.11	0.4	0.37	neutral	0.79	disease	0.35	neutral	0.58	disease	1	0.52	neutral	0.52	deleterious	-6	neutral	0.67	deleterious	-0.59	medium_impact	0.12	medium_impact	-1.23	low_impact	0.15	0.8	15.27	10.16	0.28	N	0.27	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9149	9149	T	C	MI.1325	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	623	208	L	S	tTa/tCa	-1.95	0	0	probably_damaging	1	neutral	0.14	neutral	4.34	neutral	-1.5	deleterious	-4.11	medium_impact	2.42	0.76	neutral	0.53	neutral	3.86	23.50	deleterious	0.21	0.65	NA	NA	0.7	disease	0.57	disease	0.71	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	-0.15	medium_impact	0.98	medium_impact	0.62	0.9	NA	NA	0.31	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4702	4702	A	G	MI.13250	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	233	78	N	S	aAt/aGt	-0.2	0	0	benign	0	neutral	0.44	neutral	4.69	neutral	1.72	neutral	0.44	neutral_impact	-0.4	0.93	neutral	0.93	neutral	1.84	15.25	deleterious	0.45	0.55	0.33	neutral	0.45	neutral	0.21	neutral	0.45	neutral	1	0.55	neutral	0.72	deleterious	-6	neutral	0.21	neutral	1.95	medium_impact	0.15	medium_impact	-1.48	low_impact	0.33	0.8	15.27	10.16	0.4	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4702	4702	A	C	MI.13251	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	233	78	N	T	aAt/aCt	-0.2	0	0	benign	0.01	neutral	0.41	neutral	4.68	neutral	1.56	neutral	0.94	neutral_impact	-0.04	0.91	neutral	0.9	neutral	2.10	16.87	deleterious	0.27	0.45	0.29	neutral	0.47	neutral	0.18	neutral	0.44	neutral	1	0.58	neutral	0.7	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	0.12	medium_impact	-1.18	low_impact	0.33	0.8	15.27	10.16	0.47	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4703	4703	T	A	MI.13252	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	234	78	N	K	aaT/aaA	0.72	0	0.01	benign	0.13	neutral	0.33	neutral	4.65	neutral	0.3	neutral	-0.04	neutral_impact	0.59	0.85	neutral	0.53	neutral	4.08	23.70	deleterious	0.31	0.45	0.35	neutral	0.7	disease	0.57	disease	0.65	disease	3	0.62	neutral	0.6	deleterious	-6	neutral	0.64	deleterious	-0.04	medium_impact	0.04	medium_impact	-0.65	medium_impact	0.41	0.8	15.27	10.16	0.29	N	0.33	polymorphism	1	0.01	rs386828949	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4703	4703	T	G	MI.13253	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	234	78	N	K	aaT/aaG	0.72	0	0.01	benign	0.13	neutral	0.33	neutral	4.65	neutral	0.3	neutral	-0.04	neutral_impact	0.59	0.85	neutral	0.53	neutral	3.76	23.30	deleterious	0.31	0.45	0.35	neutral	0.7	disease	0.57	disease	0.65	disease	3	0.62	neutral	0.6	deleterious	-6	neutral	0.64	deleterious	-0.04	medium_impact	0.04	medium_impact	-0.65	medium_impact	0.41	0.8	15.27	10.16	0.3	N	0.33	polymorphism	1	0.01	rs386828949	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4704	4704	A	C	MI.13254	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	235	79	M	L	Ata/Cta	-8.26	0	0.01	benign	0	neutral	0.93	neutral	4.73	neutral	1.34	neutral	-0.41	neutral_impact	0.09	0.96	neutral	0.97	neutral	-1.63	0.00	neutral	0.35	0.5	0.33	neutral	0.56	disease	0.35	neutral	0.2	neutral	6	0.06	neutral	0.97	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	0.83	medium_impact	-1.07	low_impact	0.38	0.8	11.82	8.87	0.29	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4704	4704	A	T	MI.13255	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	235	79	M	L	Ata/Tta	-8.26	0	0.01	benign	0	neutral	0.93	neutral	4.73	neutral	1.34	neutral	-0.41	neutral_impact	0.09	0.96	neutral	0.97	neutral	-1.56	0.00	neutral	0.35	0.5	0.33	neutral	0.56	disease	0.35	neutral	0.2	neutral	6	0.06	neutral	0.97	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	0.83	medium_impact	-1.07	low_impact	0.38	0.8	11.82	8.87	0.29	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4704	4704	A	G	MI.13256	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	235	79	M	V	Ata/Gta	-8.26	0	0.01	benign	0.01	neutral	0.5	neutral	4.72	neutral	1.3	neutral	-2.04	low_impact	1.4	0.91	neutral	0.76	neutral	-0.70	0.07	neutral	0.29	0.45	0.48	neutral	0.67	disease	0.63	disease	0.64	disease	3	0.49	neutral	0.75	deleterious	-6	neutral	0.22	neutral	1.03	medium_impact	0.21	medium_impact	0.03	medium_impact	0.41	0.8	11.82	8.87	0.22	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4705	4705	T	A	MI.13257	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	236	79	M	K	aTa/aAa	-0.43	0	0.02	benign	0.41	neutral	0.34	neutral	4.63	neutral	-0.46	deleterious	-4.52	low_impact	1.61	0.91	neutral	0.84	neutral	0.54	7.70	deleterious	0.04	0.35	0.33	neutral	0.86	disease	0.71	disease	0.65	disease	3	0.61	neutral	0.47	neutral	-6	neutral	0.61	deleterious	-0.65	medium_impact	0.05	medium_impact	0.21	medium_impact	0.17	0.8	11.82	8.87	0.39	N	0.42	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4705	4705	T	C	MI.13258	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	236	79	M	T	aTa/aCa	-0.43	0	0.02	benign	0.18	neutral	0.43	neutral	4.66	neutral	0.39	deleterious	-3.88	low_impact	1.26	0.92	neutral	0.91	neutral	-0.41	0.36	neutral	0.11	0.4	0.42	neutral	0.7	disease	0.62	disease	0.63	disease	3	0.48	neutral	0.63	deleterious	-6	neutral	0.42	neutral	-0.19	medium_impact	0.14	medium_impact	-0.08	medium_impact	0.16	0.8	11.82	8.87	0.34	N	0.17	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4706	4706	A	T	MI.13259	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	237	79	M	I	atA/atT	0.72	0	0.01	benign	0.06	neutral	0.55	neutral	4.66	neutral	0.4	neutral	-1.6	neutral_impact	0.74	0.91	neutral	0.89	neutral	0.11	3.72	deleterious	0.26	0.45	0.63	disease	0.76	disease	0.37	neutral	0.41	neutral	2	0.39	neutral	0.75	deleterious	-6	neutral	0.34	neutral	0.3	medium_impact	0.26	medium_impact	-0.52	medium_impact	0.38	0.8	11.82	8.87	0.25	N	0.34	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9149	9149	T	G	MI.1326	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	623	208	L	W	tTa/tGa	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	4.26	deleterious	-4.2	deleterious	-4.18	medium_impact	3.23	0.76	neutral	0.44	neutral	3.85	23.40	deleterious	0.13	0.65	NA	NA	0.83	disease	0.59	disease	0.77	disease	5	1	deleterious	0	neutral	5	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	1.67	medium_impact	0.50	0.9	NA	NA	0.34	N	0.87	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4706	4706	A	C	MI.13260	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	237	79	M	I	atA/atC	0.72	0	0.01	benign	0.06	neutral	0.55	neutral	4.66	neutral	0.4	neutral	-1.6	neutral_impact	0.74	0.91	neutral	0.89	neutral	0.06	3.24	deleterious	0.26	0.45	0.63	disease	0.76	disease	0.37	neutral	0.41	neutral	2	0.39	neutral	0.75	deleterious	-6	neutral	0.34	neutral	0.3	medium_impact	0.26	medium_impact	-0.52	medium_impact	0.38	0.8	11.82	8.87	0.25	N	0.34	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4707	4707	C	T	MI.13261	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	238	80	L	F	Ctc/Ttc	-0.43	0	0	benign	0.01	neutral	0.91	neutral	4.52	neutral	-1.14	neutral	2.32	neutral_impact	0.44	0.95	neutral	0.91	neutral	0.24	5.11	deleterious	0.23	0.45	0.54	disease	0.38	neutral	0.24	neutral	0.44	neutral	1	0.06	neutral	0.95	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.77	medium_impact	-0.77	medium_impact	0.60	0.8	12.39	10.1	0.23	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4707	4707	C	G	MI.13262	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	238	80	L	V	Ctc/Gtc	-0.43	0	0	benign	0.01	neutral	0.54	neutral	4.5	neutral	-1.42	neutral	-0.34	low_impact	1.57	0.89	neutral	0.7	neutral	0.33	6.01	deleterious	0.29	0.45	0.49	neutral	0.35	neutral	0.4	neutral	0.4	neutral	2	0.44	neutral	0.77	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.25	medium_impact	0.18	medium_impact	0.55	0.8	12.39	10.1	0.34	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4707	4707	C	A	MI.13263	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	238	80	L	I	Ctc/Atc	-0.43	0	0	benign	0.02	neutral	0.62	neutral	4.59	neutral	-0.37	neutral	-0.17	low_impact	1	0.89	neutral	0.74	neutral	0.95	10.38	neutral	0.32	0.5	0.5	neutral	0.44	neutral	0.23	neutral	0.26	neutral	5	0.35	neutral	0.8	deleterious	-6	neutral	0.18	neutral	0.75	medium_impact	0.33	medium_impact	-0.3	medium_impact	0.61	0.8	12.39	10.1	0.35	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4708	4708	T	G	MI.13264	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	239	80	L	R	cTc/cGc	-5.96	0	0	possibly_damaging	0.58	neutral	0.33	neutral	4.43	deleterious	-3.05	neutral	-0.58	medium_impact	2.66	0.83	neutral	0.44	neutral	2.83	21.50	deleterious	0.03	0.35	0.75	disease	0.84	disease	0.59	disease	0.73	disease	5	0.68	neutral	0.38	neutral	0	NA	0.72	deleterious	-0.93	medium_impact	0.04	medium_impact	1.1	medium_impact	0.06	0.8	12.39	10.1	0.31	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4708	4708	T	C	MI.13265	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	239	80	L	P	cTc/cCc	-5.96	0	0	possibly_damaging	0.66	neutral	0.19	neutral	4.42	deleterious	-3.91	neutral	-1.62	low_impact	1.86	0.74	neutral	0.36	neutral	2.69	20.80	deleterious	0.03	0.35	0.82	disease	0.84	disease	0.62	disease	0.73	disease	5	0.83	neutral	0.27	neutral	-3	neutral	0.77	deleterious	-1.06	low_impact	-0.14	medium_impact	0.42	medium_impact	0.10	0.8	12.39	10.1	0.26	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4708	4708	T	A	MI.13266	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	239	80	L	H	cTc/cAc	-5.96	0	0	possibly_damaging	0.67	neutral	0.54	neutral	4.43	neutral	-2.97	neutral	2.13	neutral_impact	0.72	0.81	neutral	0.96	neutral	2.52	19.57	deleterious	0.06	0.35	0.72	disease	0.36	neutral	0.33	neutral	0.63	disease	3	0.63	neutral	0.44	neutral	-3	neutral	0.63	deleterious	-1.08	low_impact	0.25	medium_impact	-0.54	medium_impact	0.12	0.8	12.39	10.1	0.31	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4710	4710	T	A	MI.13267	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	241	81	S	T	Tcc/Acc	-9.41	0	0	benign	0.17	neutral	0.52	neutral	4.76	neutral	0.74	neutral	-1.98	neutral_impact	-0.33	0.88	neutral	0.95	neutral	1.49	13.25	neutral	0.31	0.5	0.54	disease	0.12	neutral	0.21	neutral	0.34	neutral	3	0.38	neutral	0.68	deleterious	-6	neutral	0.61	deleterious	-0.17	medium_impact	0.23	medium_impact	-1.42	low_impact	0.52	0.8	1.15	8.24	0.39	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4710	4710	T	C	MI.13268	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	241	81	S	P	Tcc/Ccc	-9.41	0	0	benign	0	neutral	0.2	neutral	4.51	deleterious	-3.47	deleterious	-3.82	medium_impact	2.12	0.87	neutral	0.41	neutral	3.74	23.30	deleterious	0.06	0.35	0.86	disease	0.9	disease	0.61	disease	0.68	disease	4	0.8	neutral	0.6	deleterious	-3	neutral	0.35	neutral	1.95	medium_impact	-0.13	medium_impact	0.64	medium_impact	0.14	0.8	1.15	8.24	0.32	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4710	4710	T	G	MI.13269	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	241	81	S	A	Tcc/Gcc	-9.41	0	0	benign	0.06	neutral	0.51	neutral	4.6	neutral	-0.47	neutral	-2.47	low_impact	1.64	0.91	neutral	0.58	neutral	3.49	23.10	deleterious	0.3	0.45	0.61	disease	0.54	disease	0.57	disease	0.66	disease	3	0.43	neutral	0.73	deleterious	-6	neutral	0.60	deleterious	0.3	medium_impact	0.22	medium_impact	0.24	medium_impact	0.28	0.8	1.15	8.24	0.28	N	0.38	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9150	9150	A	C	MI.1327	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	624	208	L	F	ttA/ttC	7.53	0.98	0	probably_damaging	1	neutral	0.59	neutral	4.34	neutral	1.21	deleterious	-2.73	low_impact	0.84	0.82	neutral	0.69	neutral	3.54	23.10	deleterious	0.35	0.65	NA	NA	0.67	disease	0.37	neutral	0.49	neutral	0	0.99	deleterious	0.3	neutral	-2	neutral	0.84	deleterious	-3.6	low_impact	0.38	medium_impact	-0.38	medium_impact	0.59	0.9	NA	NA	0.42	N	0.57	disease_causing	0.84	0.07	rs193303047	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4711	4711	C	T	MI.13270	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	242	81	S	F	tCc/tTc	0.03	0	0	benign	0.01	neutral	0.75	neutral	4.53	neutral	-2.87	deleterious	-5.17	low_impact	1.43	0.93	neutral	0.46	neutral	4.11	23.70	deleterious	0.05	0.35	0.53	disease	0.84	disease	0.64	disease	0.74	disease	5	0.23	neutral	0.87	deleterious	-6	neutral	0.74	deleterious	1.03	medium_impact	0.47	medium_impact	0.06	medium_impact	0.06	0.8	1.15	8.24	0.21	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4711	4711	C	A	MI.13271	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	242	81	S	Y	tCc/tAc	0.03	0	0	benign	0	neutral	1	neutral	4.53	deleterious	-3.38	deleterious	-5.12	low_impact	1.89	0.92	neutral	0.61	neutral	3.88	23.50	deleterious	0.04	0.35	0.76	disease	0.81	disease	0.59	disease	0.7	disease	4	0	neutral	1	deleterious	-6	neutral	0.34	neutral	1.95	medium_impact	1.87	high_impact	0.45	medium_impact	0.12	0.8	1.15	8.24	0.23	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4711	4711	C	G	MI.13272	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	242	81	S	C	tCc/tGc	0.03	0	0	possibly_damaging	0.7	neutral	0.18	neutral	4.51	deleterious	-4.87	deleterious	-4.27	medium_impact	2.38	0.89	neutral	0.39	neutral	3.45	23.00	deleterious	0.06	0.35	0.84	disease	0.83	disease	0.61	disease	0.7	disease	4	0.85	neutral	0.24	neutral	0	NA	0.80	deleterious	-1.13	low_impact	-0.16	medium_impact	0.86	medium_impact	0.17	0.8	1.15	8.24	0.43	N	0.59	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4713	4713	G	C	MI.13273	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	244	82	G	R	Gga/Cga	-2.5	0	0	probably_damaging	0.98	neutral	0.34	neutral	4.31	deleterious	-4.04	deleterious	-7.62	high_impact	3.77	0.78	neutral	0.26	damaging	3.89	23.50	deleterious	0.03	0.35	0.4	neutral	0.9	disease	0.86	disease	0.74	disease	5	0.98	neutral	0.18	neutral	2	deleterious	0.83	deleterious	-2.34	low_impact	0.05	medium_impact	2.03	high_impact	0.64	0.8	0.58	8.01	0.42	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4713	4713	G	T	MI.13274	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	244	82	G	W	Gga/Tga	-2.5	0	0	probably_damaging	1	neutral	0.18	neutral	4.26	deleterious	-7.22	deleterious	-7.65	high_impact	3.77	0.77	neutral	0.25	damaging	4.33	24.00	deleterious	0.05	0.35	0.95	disease	0.88	disease	0.81	disease	0.65	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.16	medium_impact	2.03	high_impact	0.11	0.8	0.58	8.01	0.4	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4714	4714	G	T	MI.13275	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	245	82	G	V	gGa/gTa	2.79	1	0	probably_damaging	0.99	neutral	0.53	neutral	4.29	deleterious	-4.18	deleterious	-8.59	medium_impact	2.87	0.68	neutral	0.32	neutral	3.68	23.30	deleterious	0.03	0.35	0.76	disease	0.85	disease	0.79	disease	0.69	disease	4	0.99	deleterious	0.27	neutral	1	deleterious	0.83	deleterious	-2.62	low_impact	0.24	medium_impact	1.27	medium_impact	0.10	0.8	0.58	8.01	0.48	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4714	4714	G	A	MI.13276	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	245	82	G	E	gGa/gAa	2.79	1	0	possibly_damaging	0.47	neutral	0.27	neutral	4.35	deleterious	-3.38	deleterious	-7.59	medium_impact	2.29	0.85	neutral	0.33	neutral	3.78	23.40	deleterious	0.02	0.35	0.34	neutral	0.89	disease	0.85	disease	0.72	disease	4	0.7	neutral	0.4	neutral	0	NA	0.69	deleterious	-0.75	medium_impact	-0.03	medium_impact	0.78	medium_impact	0.23	0.8	0.58	8.01	0.5	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4714	4714	G	C	MI.13277	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	245	82	G	A	gGa/gCa	2.79	1	0	probably_damaging	0.92	neutral	0.51	neutral	4.33	neutral	-2.97	deleterious	-5.7	medium_impact	3.08	0.76	neutral	0.41	neutral	3.04	22.40	deleterious	0.1	0.4	0.42	neutral	0.71	disease	0.75	disease	0.69	disease	4	0.91	neutral	0.3	neutral	1	deleterious	0.76	deleterious	-1.77	low_impact	0.22	medium_impact	1.45	medium_impact	0.32	0.8	0.58	8.01	0.45	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4716	4716	C	A	MI.13278	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	247	83	Q	K	Caa/Aaa	-5.73	0	0	possibly_damaging	0.53	neutral	0.33	neutral	4.63	neutral	-0.16	deleterious	-3.36	medium_impact	2.48	0.85	neutral	0.38	neutral	3.81	23.40	deleterious	0.28	0.45	0.36	neutral	0.83	disease	0.69	disease	0.67	disease	3	0.66	neutral	0.4	neutral	0	NA	0.65	deleterious	-0.84	medium_impact	0.04	medium_impact	0.94	medium_impact	0.33	0.8	3.75	8.9	0.3	N	0.58	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4716	4716	C	G	MI.13279	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	247	83	Q	E	Caa/Gaa	-5.73	0	0	benign	0.34	neutral	0.33	neutral	4.65	neutral	0.07	neutral	-2.3	low_impact	1.62	0.9	neutral	0.61	neutral	2.87	21.70	deleterious	0.32	0.5	0.37	neutral	0.44	neutral	0.43	neutral	0.39	neutral	2	0.61	neutral	0.5	deleterious	-6	neutral	0.53	deleterious	-0.53	medium_impact	0.04	medium_impact	0.22	medium_impact	0.33	0.8	3.75	8.9	0.39	N	0.54	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9150	9150	A	T	MI.1328	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	624	208	L	F	ttA/ttT	7.53	0.98	0	probably_damaging	1	neutral	0.59	neutral	4.34	neutral	1.21	deleterious	-2.73	low_impact	0.84	0.82	neutral	0.69	neutral	3.68	23.30	deleterious	0.35	0.65	NA	NA	0.67	disease	0.37	neutral	0.49	neutral	0	0.99	deleterious	0.3	neutral	-2	neutral	0.84	deleterious	-3.6	low_impact	0.38	medium_impact	-0.38	medium_impact	0.59	0.9	NA	NA	0.43	N	0.57	disease_causing	0.84	0.07	rs193303047	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4717	4717	A	T	MI.13280	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	248	83	Q	L	cAa/cTa	0.03	0	0	benign	0.37	neutral	0.68	neutral	4.6	neutral	-0.69	deleterious	-6.14	medium_impact	2.31	0.92	neutral	0.65	neutral	3.47	23.00	deleterious	0.1	0.4	0.74	disease	0.81	disease	0.57	disease	0.53	disease	1	0.29	neutral	0.66	deleterious	-3	neutral	0.62	deleterious	-0.59	medium_impact	0.39	medium_impact	0.8	medium_impact	0.14	0.8	3.75	8.9	0.25	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4717	4717	A	C	MI.13281	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	248	83	Q	P	cAa/cCa	0.03	0	0	possibly_damaging	0.87	neutral	0.23	neutral	4.55	neutral	-2.32	deleterious	-5.16	medium_impact	2.48	0.74	neutral	0.32	neutral	3.14	22.60	deleterious	0.03	0.35	0.73	disease	0.88	disease	0.69	disease	0.71	disease	4	0.91	neutral	0.18	neutral	0	NA	0.83	deleterious	-1.55	low_impact	-0.08	medium_impact	0.94	medium_impact	0.17	0.8	3.75	8.9	0.29	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4717	4717	A	G	MI.13282	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	248	83	Q	R	cAa/cGa	0.03	0	0	possibly_damaging	0.59	neutral	0.36	neutral	4.59	neutral	-0.9	deleterious	-3.27	high_impact	3.63	0.84	neutral	0.39	neutral	3.23	22.80	deleterious	0.23	0.45	0.32	neutral	0.83	disease	0.71	disease	0.7	disease	4	0.66	neutral	0.39	neutral	1	deleterious	0.66	deleterious	-0.94	medium_impact	0.07	medium_impact	1.91	medium_impact	0.14	0.8	3.75	8.9	0.36	N	0.46	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4718	4718	A	T	MI.13283	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	249	83	Q	H	caA/caT	1.18	0	0	benign	0.04	neutral	0.54	neutral	4.56	neutral	-2.03	deleterious	-3.07	medium_impact	2.39	0.9	neutral	0.91	neutral	2.36	18.57	deleterious	0.27	0.45	0.42	neutral	0.7	disease	0.48	neutral	0.16	neutral	7	0.41	neutral	0.75	deleterious	-3	neutral	0.25	neutral	0.47	medium_impact	0.25	medium_impact	0.87	medium_impact	0.37	0.8	3.75	8.9	0.3	N	0.65	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4718	4718	A	C	MI.13284	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	249	83	Q	H	caA/caC	1.18	0	0	benign	0.04	neutral	0.54	neutral	4.56	neutral	-2.03	deleterious	-3.07	medium_impact	2.39	0.9	neutral	0.91	neutral	2.27	17.98	deleterious	0.27	0.45	0.42	neutral	0.7	disease	0.48	neutral	0.16	neutral	7	0.41	neutral	0.75	deleterious	-3	neutral	0.25	neutral	0.47	medium_impact	0.25	medium_impact	0.87	medium_impact	0.37	0.8	3.75	8.9	0.3	N	0.65	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4719	4719	T	G	MI.13285	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	250	84	W	G	Tga/Gga	-0.2	0	0	probably_damaging	1	neutral	0.35	neutral	4.54	neutral	-2.54	deleterious	-12.57	medium_impact	3.35	0.79	neutral	0.12	damaging	3.79	23.40	deleterious	0.06	0.35	0.74	disease	0.8	disease	0.84	disease	0.7	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.06	medium_impact	1.68	medium_impact	0.09	0.8	NA	NA	0.42	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4719	4719	T	C	MI.13286	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	250	84	W	R	Tga/Cga	-0.2	0	0	probably_damaging	1	neutral	0.35	neutral	4.54	neutral	-2.49	deleterious	-13.53	high_impact	3.9	0.77	neutral	0.1	damaging	3.51	23.10	deleterious	0.04	0.35	0.49	neutral	0.89	disease	0.86	disease	0.75	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.06	medium_impact	2.14	high_impact	0.07	0.8	NA	NA	0.47	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4720	4720	G	C	MI.13287	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	251	84	W	S	tGa/tCa	5.55	1	0	probably_damaging	1	neutral	0.46	neutral	4.56	neutral	-1.52	deleterious	-13.53	medium_impact	2.13	0.78	neutral	0.14	damaging	3.91	23.50	deleterious	0.07	0.35	0.53	disease	0.89	disease	0.82	disease	0.72	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.17	medium_impact	0.65	medium_impact	0.15	0.8	NA	NA	0.49	N	0.94	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4720	4720	G	T	MI.13288	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	251	84	W	L	tGa/tTa	5.55	1	0	probably_damaging	1	neutral	0.72	neutral	4.86	neutral	1.55	deleterious	-12.57	medium_impact	2.13	0.92	neutral	0.1	damaging	4.12	23.80	deleterious	0.1	0.4	0.55	disease	0.82	disease	0.78	disease	0.7	disease	4	1	deleterious	0.36	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.44	medium_impact	0.65	medium_impact	0.12	0.8	NA	NA	0.5	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4721	4721	A	T	MI.13289	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	252	84	W	C	tgA/tgT	6.01	1	0	probably_damaging	1	neutral	0.17	neutral	4.56	neutral	-1.65	deleterious	-12.57	medium_impact	3.35	0.74	neutral	0.09	damaging	4.00	23.60	deleterious	0.05	0.35	0.93	disease	0.9	disease	0.85	disease	0.65	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.17	medium_impact	1.68	medium_impact	0.12	0.8	NA	NA	0.63	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9151	9151	A	T	MI.1329	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	625	209	I	F	Atc/Ttc	-0.33	0.39	0	probably_damaging	0.99	deleterious	0.04	neutral	3.17	deleterious	-4.83	deleterious	-3.55	high_impact	4.49	0.55	damaging	0.45	neutral	3.85	23.40	deleterious	0.21	0.65	NA	NA	0.91	disease	0.73	disease	0.78	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.90	deleterious	-2.65	low_impact	-0.49	medium_impact	2.75	high_impact	0.64	0.9	48.67	8.76	0.51	N	0.97	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4721	4721	A	C	MI.13290	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	252	84	W	C	tgA/tgC	6.01	1	0	probably_damaging	1	neutral	0.17	neutral	4.56	neutral	-1.65	deleterious	-12.57	medium_impact	3.35	0.74	neutral	0.09	damaging	3.91	23.50	deleterious	0.05	0.35	0.93	disease	0.9	disease	0.85	disease	0.65	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.17	medium_impact	1.68	medium_impact	0.12	0.8	NA	NA	0.62	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4722	4722	A	T	MI.13291	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	253	85	T	S	Acc/Tcc	-0.66	0	0	benign	0.11	neutral	0.5	neutral	4.77	neutral	1.47	neutral	-2.22	neutral_impact	0.76	0.84	neutral	0.94	neutral	1.82	15.08	deleterious	0.43	0.55	0.51	disease	0.32	neutral	0.24	neutral	0.36	neutral	3	0.42	neutral	0.7	deleterious	-6	neutral	0.23	neutral	0.03	medium_impact	0.21	medium_impact	-0.51	medium_impact	0.52	0.8	2.59	7.58	0.36	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4722	4722	A	C	MI.13292	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	253	85	T	P	Acc/Ccc	-0.66	0	0	possibly_damaging	0.86	neutral	0.25	neutral	4.59	neutral	-1.75	deleterious	-4.45	low_impact	1.86	0.75	neutral	0.31	neutral	3.48	23.10	deleterious	0.05	0.35	0.39	neutral	0.78	disease	0.6	disease	0.69	disease	4	0.9	neutral	0.2	neutral	-3	neutral	0.71	deleterious	-1.52	low_impact	-0.06	medium_impact	0.42	medium_impact	0.23	0.8	2.59	7.58	0.33	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4722	4722	A	G	MI.13293	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	253	85	T	A	Acc/Gcc	-0.66	0	0	benign	0.02	neutral	0.58	neutral	4.64	neutral	0	deleterious	-3.06	low_impact	1.46	0.94	neutral	0.81	neutral	2.31	18.26	deleterious	0.33	0.5	0.61	disease	0.34	neutral	0.43	neutral	0.6	disease	2	0.39	neutral	0.78	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	0.29	medium_impact	0.09	medium_impact	0.33	0.8	2.59	7.58	0.28	N	0.49	polymorphism	1	0.05	.	.	.	.	.	endometrial and ovarian tumors	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4723	4723	C	A	MI.13294	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	254	85	T	N	aCc/aAc	-0.2	0	0	possibly_damaging	0.67	neutral	0.39	neutral	4.74	neutral	1.19	deleterious	-3.49	neutral_impact	0.74	0.86	neutral	0.9	neutral	2.49	19.39	deleterious	0.38	0.5	0.5	neutral	0.58	disease	0.26	neutral	0.23	neutral	5	0.7	neutral	0.36	neutral	-3	neutral	0.67	deleterious	-1.08	low_impact	0.1	medium_impact	-0.52	medium_impact	0.52	0.8	2.59	7.58	0.3	N	0.73	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4723	4723	C	G	MI.13295	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	254	85	T	S	aCc/aGc	-0.2	0	0	benign	0.11	neutral	0.5	neutral	4.77	neutral	1.47	neutral	-2.22	neutral_impact	0.76	0.84	neutral	0.94	neutral	1.92	15.70	deleterious	0.43	0.55	0.51	disease	0.32	neutral	0.24	neutral	0.36	neutral	3	0.42	neutral	0.7	deleterious	-6	neutral	0.23	neutral	0.03	medium_impact	0.21	medium_impact	-0.51	medium_impact	0.52	0.8	2.59	7.58	0.35	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4723	4723	C	T	MI.13296	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	254	85	T	I	aCc/aTc	-0.2	0	0	benign	0.09	neutral	0.44	neutral	4.61	neutral	-0.83	deleterious	-4.12	low_impact	1.86	0.94	neutral	0.5	neutral	3.80	23.40	deleterious	0.18	0.45	0.83	disease	0.63	disease	0.44	neutral	0.47	neutral	1	0.5	neutral	0.68	deleterious	-6	neutral	0.35	neutral	0.12	medium_impact	0.15	medium_impact	0.42	medium_impact	0.50	0.8	2.59	7.58	0.34	N	0.65	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4725	4725	A	G	MI.13297	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	256	86	M	V	Ata/Gta	-10.33	0	0	benign	0.01	neutral	0.58	neutral	4.73	neutral	1.6	neutral	1.08	neutral_impact	0.14	0.92	neutral	0.97	neutral	-0.67	0.09	neutral	0.25	0.45	0.44	neutral	0.28	neutral	0.37	neutral	0.42	neutral	2	0.4	neutral	0.79	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	0.29	medium_impact	-1.03	low_impact	0.36	0.8	5.76	8.39	0.33	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4725	4725	A	T	MI.13298	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	256	86	M	L	Ata/Tta	-10.33	0	0	benign	0	neutral	0.81	neutral	4.86	neutral	2.68	neutral	0.4	neutral_impact	-0.55	0.93	neutral	0.95	neutral	-0.01	2.53	deleterious	0.29	0.45	0.34	neutral	0.3	neutral	0.34	neutral	0.42	neutral	2	0.19	neutral	0.91	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.56	medium_impact	-1.61	low_impact	0.28	0.8	5.76	8.39	0.34	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4725	4725	A	C	MI.13299	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	256	86	M	L	Ata/Cta	-10.33	0	0	benign	0	neutral	0.81	neutral	4.86	neutral	2.68	neutral	0.4	neutral_impact	-0.55	0.93	neutral	0.95	neutral	-0.19	1.15	neutral	0.29	0.45	0.34	neutral	0.3	neutral	0.34	neutral	0.42	neutral	2	0.19	neutral	0.91	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.56	medium_impact	-1.61	low_impact	0.28	0.8	5.76	8.39	0.34	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8588	8588	T	A	MI.133	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	62	21	V	E	gTa/gAa	-2.42	0	0	probably_damaging	0.92	neutral	0.11	neutral	4.23	neutral	-2.99	deleterious	-3.05	low_impact	1.5	0.89	neutral	0.46	neutral	3.42	23.00	deleterious	0.17	0.65	0.74	disease	0.63	disease	0.57	disease	0.73	disease	5	0.97	neutral	0.1	neutral	-2	neutral	0.74	deleterious	-1.76	low_impact	-0.22	medium_impact	0.19	medium_impact	0.52	0.9	22.57	20.88	0.42	N	0.89	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9151	9151	A	C	MI.1330	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	625	209	I	L	Atc/Ctc	-0.33	0.39	0	probably_damaging	0.93	deleterious	0	neutral	3.63	neutral	-0.77	neutral	-1.77	medium_impact	2.33	0.54	damaging	0.47	neutral	3.89	23.50	deleterious	0.28	0.65	NA	NA	0.82	disease	0.63	disease	0.65	disease	3	1	deleterious	0.04	neutral	5	deleterious	0.80	deleterious	-1.82	low_impact	-1.4	low_impact	0.9	medium_impact	0.57	0.9	48.67	8.76	0.34	N	0.83	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4726	4726	T	A	MI.13300	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	257	86	M	K	aTa/aAa	-0.2	0	0	benign	0.09	neutral	0.33	neutral	4.62	neutral	-1	deleterious	-3.68	low_impact	1.03	0.84	neutral	0.46	neutral	1.97	16.00	deleterious	0.03	0.35	0.38	neutral	0.6	disease	0.73	disease	0.72	disease	4	0.63	neutral	0.62	deleterious	-6	neutral	0.26	neutral	0.12	medium_impact	0.04	medium_impact	-0.28	medium_impact	0.21	0.8	5.76	8.39	0.31	N	0.51	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4726	4726	T	C	MI.13301	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	257	86	M	T	aTa/aCa	-0.2	0	0	benign	0	neutral	0.49	neutral	4.68	neutral	0.86	neutral	-1.96	neutral_impact	0.51	0.94	neutral	0.95	neutral	-0.20	1.08	neutral	0.11	0.4	0.51	disease	0.5	neutral	0.56	disease	0.46	neutral	1	0.51	neutral	0.75	deleterious	-6	neutral	0.22	neutral	1.95	medium_impact	0.2	medium_impact	-0.72	medium_impact	0.13	0.8	5.76	8.39	0.29	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4727	4727	A	T	MI.13302	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	258	86	M	I	atA/atT	2.33	0.05	0.01	benign	0	neutral	0.89	neutral	4.81	neutral	2.34	neutral	1.46	neutral_impact	-1.55	0.88	neutral	0.97	neutral	-1.23	0.01	neutral	0.3	0.45	0.43	neutral	0.07	neutral	0.23	neutral	0.29	neutral	4	0.1	neutral	0.95	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.71	medium_impact	-2.45	low_impact	0.47	0.8	5.76	8.39	0.33	N	0.06	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4727	4727	A	C	MI.13303	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	258	86	M	I	atA/atC	2.33	0.05	0.01	benign	0	neutral	0.89	neutral	4.81	neutral	2.34	neutral	1.46	neutral_impact	-1.55	0.88	neutral	0.97	neutral	-1.26	0.01	neutral	0.3	0.45	0.43	neutral	0.07	neutral	0.23	neutral	0.29	neutral	4	0.1	neutral	0.95	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.71	medium_impact	-2.45	low_impact	0.47	0.8	5.76	8.39	0.34	N	0.06	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4728	4728	A	C	MI.13304	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	259	87	T	P	Acc/Ccc	-4.58	0	0	benign	0.14	neutral	0.21	neutral	4.59	neutral	-1.84	deleterious	-2.88	low_impact	1.62	0.91	neutral	0.61	neutral	1.92	15.69	deleterious	0.04	0.35	0.73	disease	0.73	disease	0.61	disease	0.6	disease	2	0.76	neutral	0.54	deleterious	-6	neutral	0.63	deleterious	-0.08	medium_impact	-0.11	medium_impact	0.22	medium_impact	0.31	0.8	12.39	9.61	0.36	N	0.75	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4728	4728	A	T	MI.13305	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	259	87	T	S	Acc/Tcc	-4.58	0	0	benign	0.03	neutral	0.44	neutral	4.63	neutral	-0.14	neutral	-1.06	neutral_impact	0.3	0.83	neutral	0.97	neutral	-0.30	0.66	neutral	0.31	0.45	0.57	disease	0.34	neutral	0.26	neutral	0.59	disease	2	0.53	neutral	0.71	deleterious	-6	neutral	0.27	neutral	0.59	medium_impact	0.15	medium_impact	-0.89	medium_impact	0.48	0.8	12.39	9.61	0.37	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4728	4728	A	G	MI.13306	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	259	87	T	A	Acc/Gcc	-4.58	0	0	benign	0	neutral	0.52	neutral	4.59	neutral	0.35	neutral	-1.76	low_impact	1.66	0.95	neutral	0.82	neutral	-0.12	1.61	neutral	0.29	0.45	0.5	neutral	0.38	neutral	0.44	neutral	0.19	neutral	6	0.48	neutral	0.76	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.23	medium_impact	0.25	medium_impact	0.32	0.8	12.39	9.61	0.29	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4729	4729	C	T	MI.13307	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	260	87	T	I	aCc/aTc	0.03	0	0	benign	0	neutral	0.41	neutral	4.54	neutral	-1.56	neutral	-1.44	low_impact	1.31	0.9	neutral	0.93	neutral	1.86	15.36	deleterious	0.14	0.4	0.48	neutral	0.55	disease	0.34	neutral	0.46	neutral	1	0.59	neutral	0.71	deleterious	-6	neutral	0.26	neutral	1.95	medium_impact	0.12	medium_impact	-0.04	medium_impact	0.54	0.8	12.39	9.61	0.35	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4729	4729	C	G	MI.13308	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	260	87	T	S	aCc/aGc	0.03	0	0	benign	0.03	neutral	0.44	neutral	4.63	neutral	-0.14	neutral	-1.06	neutral_impact	0.3	0.83	neutral	0.97	neutral	-0.12	1.58	neutral	0.31	0.45	0.57	disease	0.34	neutral	0.26	neutral	0.59	disease	2	0.53	neutral	0.71	deleterious	-6	neutral	0.27	neutral	0.59	medium_impact	0.15	medium_impact	-0.89	medium_impact	0.48	0.8	12.39	9.61	0.39	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4729	4729	C	A	MI.13309	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	260	87	T	N	aCc/aAc	0.03	0	0	benign	0	neutral	0.35	neutral	4.61	neutral	-0.89	neutral	-1.98	low_impact	0.83	0.86	neutral	0.92	neutral	1.92	15.72	deleterious	0.32	0.5	0.5	neutral	0.52	disease	0.29	neutral	0.46	neutral	1	0.65	neutral	0.68	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.06	medium_impact	-0.45	medium_impact	0.45	0.8	12.39	9.61	0.39	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9151	9151	A	G	MI.1331	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	625	209	I	V	Atc/Gtc	-0.33	0.39	0	probably_damaging	0.93	neutral	0.08	neutral	3.39	neutral	-1.83	neutral	-0.89	medium_impact	3.13	0.63	neutral	0.52	neutral	3.16	22.60	deleterious	0.4	0.65	NA	NA	0.68	disease	0.62	disease	0.66	disease	3	0.98	neutral	0.08	neutral	1	deleterious	0.79	deleterious	-1.82	low_impact	-0.31	medium_impact	1.59	medium_impact	0.64	0.9	48.67	8.76	0.35	N	0.77	disease_causing	1	0.06	rs879206297	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4731	4731	A	T	MI.13310	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	262	88	N	Y	Aat/Tat	-1.12	0	0	possibly_damaging	0.86	neutral	1	neutral	4.53	neutral	-2.47	deleterious	-4.76	low_impact	1.34	0.92	neutral	0.81	neutral	2.34	18.41	deleterious	0.15	0.4	0.75	disease	0.64	disease	0.55	disease	0.61	disease	2	0.86	neutral	0.57	deleterious	-3	neutral	0.76	deleterious	-1.52	low_impact	1.87	high_impact	-0.02	medium_impact	0.31	0.8	19.31	10	0.26	N	0.67	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4731	4731	A	C	MI.13311	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	262	88	N	H	Aat/Cat	-1.12	0	0	possibly_damaging	0.86	neutral	0.54	neutral	4.54	neutral	-1.92	deleterious	-2.68	neutral_impact	0.73	0.9	neutral	0.9	neutral	1.66	14.19	neutral	0.32	0.5	0.77	disease	0.49	neutral	0.52	disease	0.55	disease	1	0.84	neutral	0.34	neutral	-3	neutral	0.72	deleterious	-1.52	low_impact	0.25	medium_impact	-0.53	medium_impact	0.16	0.8	19.31	10	0.32	N	0.15	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4731	4731	A	G	MI.13312	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	262	88	N	D	Aat/Gat	-1.12	0	0	benign	0.2	neutral	0.22	neutral	4.6	neutral	-0.28	deleterious	-2.87	low_impact	1.44	0.9	neutral	0.68	neutral	0.74	9.07	deleterious	0.4	0.5	0.74	disease	0.54	disease	0.6	disease	0.58	disease	1	0.74	neutral	0.51	deleterious	-6	neutral	0.48	deleterious	-0.25	medium_impact	-0.1	medium_impact	0.07	medium_impact	0.34	0.8	19.31	10	0.43	N	0.51	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4732	4732	A	T	MI.13313	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	263	88	N	I	aAt/aTt	0.03	0	0.05	possibly_damaging	0.68	neutral	0.41	neutral	4.58	deleterious	-3.02	deleterious	-5.73	low_impact	1.38	0.88	neutral	0.56	neutral	2.62	20.30	deleterious	0.16	0.45	0.72	disease	0.75	disease	0.65	disease	0.71	disease	4	0.69	neutral	0.37	neutral	-3	neutral	0.72	deleterious	-1.1	low_impact	0.12	medium_impact	0.02	medium_impact	0.23	0.8	19.31	10	0.31	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4732	4732	A	G	MI.13314	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	263	88	N	S	aAt/aGt	0.03	0	0.05	benign	0.01	neutral	0.42	neutral	4.6	neutral	-0.55	neutral	-2.22	neutral_impact	0.64	0.94	neutral	0.98	neutral	-0.41	0.36	neutral	0.4	0.5	0.6	disease	0.44	neutral	0.47	neutral	0.6	disease	2	0.57	neutral	0.71	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.13	medium_impact	-0.61	medium_impact	0.26	0.8	19.31	10	0.32	N	0.29	polymorphism	1	0.02	rs201854167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4732	4732	A	C	MI.13315	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	263	88	N	T	aAt/aCt	0.03	0	0.05	benign	0.2	neutral	0.41	neutral	4.6	neutral	-1.25	deleterious	-3.29	low_impact	0.9	0.93	neutral	0.82	neutral	0.39	6.50	deleterious	0.23	0.45	0.6	disease	0.55	disease	0.47	neutral	0.46	neutral	1	0.51	neutral	0.61	deleterious	-6	neutral	0.40	neutral	-0.25	medium_impact	0.12	medium_impact	-0.39	medium_impact	0.31	0.8	19.31	10	0.35	N	0.29	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4733	4733	T	A	MI.13316	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	264	88	N	K	aaT/aaA	0.95	0	0.02	benign	0.29	neutral	0.32	neutral	4.65	neutral	-0.74	neutral	-1.4	neutral_impact	0.74	0.89	neutral	0.92	neutral	-0.20	1.09	neutral	0.36	0.5	0.49	neutral	0.48	neutral	0.5	neutral	0.45	neutral	1	0.61	neutral	0.52	deleterious	-6	neutral	0.49	deleterious	-0.44	medium_impact	0.03	medium_impact	-0.52	medium_impact	0.43	0.8	19.31	10	0.4	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4733	4733	T	G	MI.13317	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	264	88	N	K	aaT/aaG	0.95	0	0.02	benign	0.29	neutral	0.32	neutral	4.65	neutral	-0.74	neutral	-1.4	neutral_impact	0.74	0.89	neutral	0.92	neutral	-0.49	0.23	neutral	0.36	0.5	0.49	neutral	0.48	neutral	0.5	neutral	0.45	neutral	1	0.61	neutral	0.52	deleterious	-6	neutral	0.49	deleterious	-0.44	medium_impact	0.03	medium_impact	-0.52	medium_impact	0.43	0.8	19.31	10	0.41	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4734	4734	A	G	MI.13318	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	265	89	T	A	Act/Gct	-1.35	0	0	benign	0	neutral	0.53	neutral	4.63	neutral	-0.24	neutral	-0.54	low_impact	1.62	0.93	neutral	0.74	neutral	-0.12	1.60	neutral	0.28	0.45	0.46	neutral	0.24	neutral	0.46	neutral	0.44	neutral	1	0.47	neutral	0.77	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.24	medium_impact	0.22	medium_impact	0.34	0.8	17.58	9.79	0.32	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4734	4734	A	T	MI.13319	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	265	89	T	S	Act/Tct	-1.35	0	0	benign	0	neutral	0.56	neutral	4.62	neutral	-0.37	neutral	-0.43	neutral_impact	0.76	0.85	neutral	0.94	neutral	-0.47	0.26	neutral	0.42	0.55	0.49	neutral	0.25	neutral	0.43	neutral	0.4	neutral	2	0.43	neutral	0.78	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.27	medium_impact	-0.51	medium_impact	0.57	0.8	17.58	9.79	0.34	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9152	9152	T	C	MI.1332	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	626	209	I	T	aTc/aCc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	3.14	deleterious	-6.26	deleterious	-4.4	high_impact	4.49	0.62	neutral	0.53	neutral	3.59	23.20	deleterious	0.27	0.65	NA	NA	0.83	disease	0.68	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-1.4	low_impact	2.75	high_impact	0.43	0.9	48.67	8.76	0.47	N	0.99	disease_causing	1	0.40	rs878853096	Uncertain_significance	not_provided	237378	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4734	4734	A	C	MI.13320	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	265	89	T	P	Act/Cct	-1.35	0	0	benign	0	neutral	0.27	neutral	4.61	neutral	-0.73	neutral	-1.3	low_impact	0.82	0.92	neutral	0.95	neutral	0.00	2.58	deleterious	0.05	0.35	0.58	disease	0.66	disease	0.43	neutral	0.22	neutral	6	0.73	neutral	0.64	deleterious	-6	neutral	0.24	neutral	1.95	medium_impact	-0.03	medium_impact	-0.45	medium_impact	0.28	0.8	17.58	9.79	0.35	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4735	4735	C	A	MI.13321	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	266	89	T	N	aCt/aAt	-7.11	0	0.01	benign	0	neutral	0.37	neutral	4.6	neutral	-1.18	neutral	-1.25	low_impact	0.96	0.95	neutral	0.86	neutral	0.11	3.72	deleterious	0.31	0.45	0.5	disease	0.43	neutral	0.3	neutral	0.25	neutral	5	0.63	neutral	0.69	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	0.08	medium_impact	-0.34	medium_impact	0.49	0.8	17.58	9.79	0.37	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4735	4735	C	G	MI.13322	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	266	89	T	S	aCt/aGt	-7.11	0	0.01	benign	0	neutral	0.56	neutral	4.62	neutral	-0.37	neutral	-0.43	neutral_impact	0.76	0.85	neutral	0.94	neutral	-0.11	1.67	neutral	0.42	0.55	0.49	neutral	0.25	neutral	0.43	neutral	0.4	neutral	2	0.43	neutral	0.78	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.27	medium_impact	-0.51	medium_impact	0.57	0.8	17.58	9.79	0.31	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4735	4735	C	T	MI.13323	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	266	89	T	I	aCt/aTt	-7.11	0	0.01	benign	0	neutral	0.46	neutral	4.85	neutral	1.83	neutral	0.5	neutral_impact	0.38	0.95	neutral	0.97	neutral	-0.20	1.12	neutral	0.15	0.4	0.66	disease	0.33	neutral	0.31	neutral	0.61	disease	2	0.54	neutral	0.73	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	0.17	medium_impact	-0.83	medium_impact	0.54	0.8	17.58	9.79	0.4	N	0.16	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4737	4737	A	T	MI.13324	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	268	90	T	S	Acc/Tcc	-4.11	0	0	benign	0	neutral	0.45	neutral	4.68	neutral	-0.94	neutral	-0.13	neutral_impact	0.36	0.84	neutral	0.97	neutral	1.50	13.31	neutral	0.33	0.5	0.56	disease	0.18	neutral	0.19	neutral	0.4	neutral	2	0.54	neutral	0.73	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.16	medium_impact	-0.84	medium_impact	0.54	0.8	12.39	9.68	0.49	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4737	4737	A	C	MI.13325	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	268	90	T	P	Acc/Ccc	-4.11	0	0	benign	0	neutral	0.22	neutral	4.59	neutral	-2.15	neutral	-0.9	low_impact	1.46	0.95	neutral	0.89	neutral	2.37	18.63	deleterious	0.05	0.35	0.72	disease	0.72	disease	0.43	neutral	0.55	disease	1	0.78	neutral	0.61	deleterious	-6	neutral	0.25	neutral	1.95	medium_impact	-0.1	medium_impact	0.09	medium_impact	0.29	0.8	12.39	9.68	0.34	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4737	4737	A	G	MI.13326	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	268	90	T	A	Acc/Gcc	-4.11	0	0	benign	0	neutral	0.54	neutral	4.68	neutral	0.09	neutral	-0.73	low_impact	1.56	0.9	neutral	0.81	neutral	2.04	16.46	deleterious	0.26	0.45	0.53	disease	0.4	neutral	0.44	neutral	0.39	neutral	2	0.45	neutral	0.77	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.25	medium_impact	0.17	medium_impact	0.21	0.8	12.39	9.68	0.3	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4738	4738	C	T	MI.13327	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	269	90	T	I	aCc/aTc	-4.11	0	0	benign	0	neutral	0.42	neutral	4.66	neutral	-1.66	neutral	-0.85	low_impact	1.76	0.91	neutral	0.87	neutral	2.02	16.33	deleterious	0.15	0.4	0.57	disease	0.63	disease	0.46	neutral	0.49	neutral	0	0.58	neutral	0.71	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	0.13	medium_impact	0.34	medium_impact	0.52	0.8	12.39	9.68	0.27	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4738	4738	C	A	MI.13328	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	269	90	T	N	aCc/aAc	-4.11	0	0	benign	0.06	neutral	0.34	neutral	4.67	neutral	-2.19	neutral	-0.26	low_impact	0.94	0.85	neutral	0.95	neutral	1.85	15.26	deleterious	0.3	0.45	0.47	neutral	0.47	neutral	0.29	neutral	0.49	neutral	0	0.62	neutral	0.64	deleterious	-6	neutral	0.49	deleterious	0.3	medium_impact	0.05	medium_impact	-0.35	medium_impact	0.47	0.8	12.39	9.68	0.45	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4738	4738	C	G	MI.13329	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	269	90	T	S	aCc/aGc	-4.11	0	0	benign	0	neutral	0.45	neutral	4.68	neutral	-0.94	neutral	-0.13	neutral_impact	0.36	0.84	neutral	0.97	neutral	1.19	11.67	neutral	0.33	0.5	0.56	disease	0.18	neutral	0.19	neutral	0.4	neutral	2	0.54	neutral	0.73	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.16	medium_impact	-0.84	medium_impact	0.54	0.8	12.39	9.68	0.49	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9152	9152	T	G	MI.1333	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	626	209	I	S	aTc/aGc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	3.14	deleterious	-7.61	deleterious	-5.29	high_impact	4.14	0.56	damaging	0.6	neutral	4.40	24.10	deleterious	0.18	0.65	NA	NA	0.92	disease	0.69	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.65	low_impact	-1.4	low_impact	2.45	high_impact	0.35	0.9	48.67	8.76	0.42	N	0.98	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4740	4740	A	T	MI.13330	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	271	91	N	Y	Aat/Tat	-8.95	0	0	probably_damaging	0.96	neutral	1	neutral	4.5	deleterious	-3.24	deleterious	-6.75	low_impact	1.82	0.91	neutral	0.66	neutral	3.55	23.10	deleterious	0.16	0.45	0.4	neutral	0.8	disease	0.4	neutral	0.49	neutral	0	0.96	neutral	0.52	deleterious	-2	neutral	0.73	deleterious	-2.06	low_impact	1.87	high_impact	0.39	medium_impact	0.24	0.8	1.15	7.43	0.25	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4740	4740	A	C	MI.13331	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	271	91	N	H	Aat/Cat	-8.95	0	0	probably_damaging	0.96	neutral	0.55	neutral	4.51	neutral	-2.59	deleterious	-4.08	neutral_impact	0.32	0.82	neutral	0.94	neutral	1.81	15.07	deleterious	0.39	0.5	0.63	disease	0.28	neutral	0.31	neutral	0.57	disease	1	0.96	neutral	0.3	neutral	-2	neutral	0.70	deleterious	-2.06	low_impact	0.26	medium_impact	-0.88	medium_impact	0.10	0.8	1.15	7.43	0.29	N	0.62	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4740	4740	A	G	MI.13332	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	271	91	N	D	Aat/Gat	-8.95	0	0	benign	0.03	neutral	0.21	neutral	4.55	neutral	-1.29	deleterious	-3.71	neutral_impact	0.72	0.82	neutral	0.95	neutral	2.45	19.14	deleterious	0.53	0.6	0.59	disease	0.62	disease	0.35	neutral	0.27	neutral	5	0.78	neutral	0.59	deleterious	-6	neutral	0.22	neutral	0.59	medium_impact	-0.11	medium_impact	-0.54	medium_impact	0.32	0.8	1.15	7.43	0.36	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4741	4741	A	G	MI.13333	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	272	91	N	S	aAt/aGt	0.03	0	0	benign	0.06	neutral	0.41	neutral	4.59	neutral	-0.57	deleterious	-3.71	low_impact	1.01	0.85	neutral	0.98	neutral	1.79	14.90	neutral	0.51	0.6	0.6	disease	0.57	disease	0.31	neutral	0.28	neutral	4	0.55	neutral	0.68	deleterious	-6	neutral	0.28	neutral	0.3	medium_impact	0.12	medium_impact	-0.29	medium_impact	0.19	0.8	1.15	7.43	0.33	N	0.07	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4741	4741	A	C	MI.13334	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	272	91	N	T	aAt/aCt	0.03	0	0	possibly_damaging	0.54	neutral	0.39	neutral	4.64	neutral	-0.07	deleterious	-4.83	low_impact	1.06	0.88	neutral	0.73	neutral	3.34	22.90	deleterious	0.33	0.5	0.71	disease	0.68	disease	0.27	neutral	0.3	neutral	4	0.61	neutral	0.43	neutral	-3	neutral	0.64	deleterious	-0.86	medium_impact	0.1	medium_impact	-0.25	medium_impact	0.24	0.8	1.15	7.43	0.36	N	0.65	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4741	4741	A	T	MI.13335	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	272	91	N	I	aAt/aTt	0.03	0	0	probably_damaging	0.92	neutral	0.4	neutral	4.51	neutral	-2.68	deleterious	-7.62	medium_impact	1.94	0.9	neutral	0.48	neutral	3.94	23.50	deleterious	0.17	0.45	0.67	disease	0.88	disease	0.53	disease	0.73	disease	5	0.92	neutral	0.24	neutral	1	deleterious	0.79	deleterious	-1.77	low_impact	0.11	medium_impact	0.49	medium_impact	0.17	0.8	1.15	7.43	0.37	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4742	4742	T	G	MI.13336	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	273	91	N	K	aaT/aaG	0.95	0	0.01	possibly_damaging	0.62	neutral	0.29	neutral	4.67	neutral	0.27	deleterious	-4.94	medium_impact	2	0.89	neutral	0.38	neutral	3.91	23.50	deleterious	0.42	0.55	0.53	disease	0.8	disease	0.6	disease	0.71	disease	4	0.74	neutral	0.34	neutral	0	NA	0.69	deleterious	-0.99	medium_impact	-0.01	medium_impact	0.54	medium_impact	0.39	0.8	1.15	7.43	0.39	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4742	4742	T	A	MI.13337	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	273	91	N	K	aaT/aaA	0.95	0	0.01	possibly_damaging	0.62	neutral	0.29	neutral	4.67	neutral	0.27	deleterious	-4.94	medium_impact	2	0.89	neutral	0.38	neutral	4.18	23.80	deleterious	0.42	0.55	0.53	disease	0.8	disease	0.6	disease	0.71	disease	4	0.74	neutral	0.34	neutral	0	NA	0.69	deleterious	-0.99	medium_impact	-0.01	medium_impact	0.54	medium_impact	0.39	0.8	1.15	7.43	0.39	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4743	4743	C	A	MI.13338	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	274	92	Q	K	Caa/Aaa	-0.89	0	0	benign	0.04	neutral	0.46	neutral	4.66	neutral	0.4	neutral	-1.26	neutral_impact	0.19	0.86	neutral	0.72	neutral	1.11	11.26	neutral	0.33	0.5	0.49	neutral	0.73	disease	0.5	neutral	0.38	neutral	2	0.5	neutral	0.71	deleterious	-6	neutral	0.24	neutral	0.47	medium_impact	0.17	medium_impact	-0.98	medium_impact	0.31	0.8	12.68	9.01	0.23	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4743	4743	C	G	MI.13339	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	274	92	Q	E	Caa/Gaa	-0.89	0	0	benign	0.33	neutral	0.44	neutral	4.68	neutral	0.91	neutral	-0.91	neutral_impact	0.7	0.89	neutral	0.75	neutral	0.09	3.55	deleterious	0.37	0.5	0.49	neutral	0.71	disease	0.49	neutral	0.38	neutral	3	0.48	neutral	0.56	deleterious	-6	neutral	0.48	deleterious	-0.52	medium_impact	0.15	medium_impact	-0.56	medium_impact	0.43	0.8	12.68	9.01	0.32	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9152	9152	T	A	MI.1334	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	626	209	I	N	aTc/aAc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	3.13	deleterious	-8.46	deleterious	-6.21	high_impact	4.14	0.54	damaging	0.49	neutral	4.74	24.70	deleterious	0.2	0.65	NA	NA	0.91	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.45	high_impact	0.41	0.9	48.67	8.76	0.43	N	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4744	4744	A	G	MI.13340	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	275	92	Q	R	cAa/cGa	-0.43	0	0	possibly_damaging	0.44	neutral	0.43	neutral	4.64	neutral	-0.02	neutral	-1.62	medium_impact	2.02	0.89	neutral	0.51	neutral	1.64	14.08	neutral	0.31	0.45	0.53	disease	0.83	disease	0.52	disease	0.7	disease	4	0.53	neutral	0.5	deleterious	0	NA	0.60	deleterious	-0.7	medium_impact	0.14	medium_impact	0.56	medium_impact	0.11	0.8	12.68	9.01	0.35	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4744	4744	A	C	MI.13341	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	275	92	Q	P	cAa/cCa	-0.43	0	0	benign	0.04	neutral	0.33	neutral	4.66	neutral	0.57	neutral	0.8	neutral_impact	-1.32	0.92	neutral	0.98	neutral	-1.43	0.00	neutral	0.07	0.35	0.48	neutral	0.23	neutral	0.4	neutral	0.38	neutral	2	0.65	neutral	0.65	deleterious	-6	neutral	0.18	neutral	0.47	medium_impact	0.04	medium_impact	-2.26	low_impact	0.38	0.8	12.68	9.01	0.38	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4744	4744	A	T	MI.13342	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	275	92	Q	L	cAa/cTa	-0.43	0	0	possibly_damaging	0.61	neutral	0.76	neutral	4.84	neutral	2.77	deleterious	-3.06	neutral_impact	0.57	0.9	neutral	0.68	neutral	0.81	9.53	deleterious	0.12	0.4	0.39	neutral	0.75	disease	0.45	neutral	0.42	neutral	2	0.52	neutral	0.58	deleterious	-3	neutral	0.60	deleterious	-0.98	medium_impact	0.49	medium_impact	-0.67	medium_impact	0.07	0.8	12.68	9.01	0.29	N	0.81	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4745	4745	A	C	MI.13343	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	276	92	Q	H	caA/caC	-0.2	0	0.02	probably_damaging	0.95	neutral	0.56	neutral	4.63	neutral	-0.82	neutral	-0.91	neutral_impact	0.78	0.89	neutral	0.94	neutral	1.98	16.05	deleterious	0.3	0.45	0.74	disease	0.53	disease	0.33	neutral	0.3	neutral	4	0.94	neutral	0.31	neutral	-2	neutral	0.75	deleterious	-1.97	low_impact	0.27	medium_impact	-0.49	medium_impact	0.38	0.8	12.68	9.01	0.33	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4745	4745	A	T	MI.13344	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	276	92	Q	H	caA/caT	-0.2	0	0.02	probably_damaging	0.95	neutral	0.56	neutral	4.63	neutral	-0.82	neutral	-0.91	neutral_impact	0.78	0.89	neutral	0.94	neutral	2.11	16.94	deleterious	0.3	0.45	0.74	disease	0.53	disease	0.33	neutral	0.3	neutral	4	0.94	neutral	0.31	neutral	-2	neutral	0.75	deleterious	-1.97	low_impact	0.27	medium_impact	-0.49	medium_impact	0.38	0.8	12.68	9.01	0.33	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4746	4746	T	G	MI.13345	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	277	93	Y	D	Tac/Gac	-4.35	0	0	benign	0.3	neutral	0.29	neutral	4.62	deleterious	-3.51	neutral	-1.55	low_impact	1.49	0.88	neutral	0.41	neutral	2.48	19.35	deleterious	0.05	0.35	0.96	disease	0.71	disease	0.58	disease	0.83	disease	7	0.65	neutral	0.5	deleterious	-6	neutral	0.59	deleterious	-0.46	medium_impact	-0.01	medium_impact	0.11	medium_impact	0.09	0.8	7.49	8.66	0.31	N	0.71	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4746	4746	T	A	MI.13346	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	277	93	Y	N	Tac/Aac	-4.35	0	0	benign	0.3	neutral	0.47	neutral	4.63	deleterious	-3.04	neutral	-0.88	neutral_impact	0.29	0.9	neutral	0.82	neutral	2.53	19.68	deleterious	0.1	0.4	0.94	disease	0.57	disease	0.45	neutral	0.76	disease	5	0.44	neutral	0.59	deleterious	-6	neutral	0.55	deleterious	-0.46	medium_impact	0.18	medium_impact	-0.9	medium_impact	0.08	0.8	7.49	8.66	0.34	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4746	4746	T	C	MI.13347	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	277	93	Y	H	Tac/Cac	-4.35	0	0	possibly_damaging	0.77	neutral	0.44	neutral	4.63	neutral	-1.9	neutral	-1.27	low_impact	0.86	0.89	neutral	0.51	neutral	1.58	13.75	neutral	0.22	0.45	0.94	disease	0.49	neutral	0.32	neutral	0.73	disease	5	0.76	neutral	0.34	neutral	-3	neutral	0.73	deleterious	-1.28	low_impact	0.15	medium_impact	-0.42	medium_impact	0.16	0.8	7.49	8.66	0.34	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4747	4747	A	C	MI.13348	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	278	93	Y	S	tAc/tCc	-5.5	0	0	benign	0.12	neutral	0.55	neutral	4.66	neutral	-1.76	neutral	0.08	neutral_impact	0.31	0.88	neutral	0.91	neutral	1.73	14.59	neutral	0.07	0.35	0.85	disease	0.54	disease	0.44	neutral	0.63	disease	3	0.36	neutral	0.72	deleterious	-6	neutral	0.37	neutral	-0.01	medium_impact	0.26	medium_impact	-0.88	medium_impact	0.15	0.8	7.49	8.66	0.28	N	0.56	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4747	4747	A	T	MI.13349	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	278	93	Y	F	tAc/tTc	-5.5	0	0	benign	0	neutral	0.72	neutral	4.79	neutral	0.32	neutral	0.48	neutral_impact	0.06	0.9	neutral	0.89	neutral	0.85	9.75	deleterious	0.35	0.5	0.62	disease	0.46	neutral	0.22	neutral	0.59	disease	2	0.27	neutral	0.86	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	0.44	medium_impact	-1.09	low_impact	0.34	0.8	7.49	8.66	0.31	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9153	9153	C	A	MI.1335	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	627	209	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	3.18	deleterious	-4.45	deleterious	-2.66	high_impact	3.94	0.59	damaging	0.59	neutral	3.98	23.60	deleterious	0.29	0.65	NA	NA	0.81	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.28	high_impact	0.70	0.9	48.67	8.76	0.46	N	0.75	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4747	4747	A	G	MI.13350	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	278	93	Y	C	tAc/tGc	-5.5	0	0	possibly_damaging	0.77	neutral	0.16	neutral	4.63	deleterious	-3.1	neutral	-0.16	low_impact	1.83	0.84	neutral	0.41	neutral	1.95	15.91	deleterious	0.05	0.35	0.94	disease	0.75	disease	0.46	neutral	0.79	disease	6	0.89	neutral	0.2	neutral	-3	neutral	0.74	deleterious	-1.28	low_impact	-0.19	medium_impact	0.4	medium_impact	0.01	0.8	7.49	8.66	0.38	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4749	4749	T	A	MI.13351	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	280	94	S	T	Tca/Aca	-8.72	0	0	benign	0.02	neutral	0.6	neutral	4.56	neutral	-1.31	neutral	-0.44	neutral_impact	0.74	0.9	neutral	0.93	neutral	2.39	18.75	deleterious	0.27	0.45	0.25	neutral	0.65	disease	0.28	neutral	0.24	neutral	5	0.37	neutral	0.79	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.31	medium_impact	-0.52	medium_impact	0.55	0.8	10.95	9.28	0.32	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4749	4749	T	G	MI.13352	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	280	94	S	A	Tca/Gca	-8.72	0	0	benign	0.19	neutral	0.81	neutral	4.63	neutral	-0.14	neutral	0.89	neutral_impact	-0.6	0.91	neutral	0.97	neutral	0.81	9.55	deleterious	0.26	0.45	0.21	neutral	0.22	neutral	0.22	neutral	0.42	neutral	2	0.11	neutral	0.81	deleterious	-6	neutral	0.25	neutral	-0.22	medium_impact	0.56	medium_impact	-1.65	low_impact	0.39	0.8	10.95	9.28	0.29	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4749	4749	T	C	MI.13353	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	280	94	S	P	Tca/Cca	-8.72	0	0	benign	0.01	neutral	0.33	neutral	4.55	neutral	-1.64	neutral	-1.45	neutral_impact	0.44	0.89	neutral	0.98	neutral	2.66	20.60	deleterious	0.07	0.35	0.48	neutral	0.77	disease	0.39	neutral	0.23	neutral	5	0.66	neutral	0.66	deleterious	-6	neutral	0.25	neutral	1.03	medium_impact	0.04	medium_impact	-0.77	medium_impact	0.21	0.8	10.95	9.28	0.33	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4750	4750	C	G	MI.13354	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	281	94	S	W	tCa/tGa	-2.5	0	0	possibly_damaging	0.89	deleterious	0.02	neutral	4.52	neutral	-2.58	deleterious	-3.89	medium_impact	2.73	0.86	neutral	0.47	neutral	4.23	23.90	deleterious	0.06	0.35	0.79	disease	0.89	disease	0.66	disease	0.72	disease	4	0.99	deleterious	0.07	neutral	4	deleterious	0.78	deleterious	-1.63	low_impact	-0.73	medium_impact	1.15	medium_impact	0.13	0.8	10.95	9.28	0.35	N	0.63	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4750	4750	C	T	MI.13355	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	281	94	S	L	tCa/tTa	-2.5	0	0	benign	0.01	neutral	0.44	neutral	4.77	neutral	0.98	neutral	-2.12	low_impact	1.12	0.9	neutral	0.85	neutral	3.35	22.90	deleterious	0.1	0.4	0.23	neutral	0.85	disease	0.48	neutral	0.5	neutral	0	0.55	neutral	0.72	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.15	medium_impact	-0.2	medium_impact	0.43	0.8	10.95	9.28	0.32	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4752	4752	T	C	MI.13356	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	283	95	S	P	Tca/Cca	-6.88	0	0	benign	0.05	neutral	0.21	neutral	4.48	neutral	-1.65	deleterious	-3.1	medium_impact	2.06	0.9	neutral	0.62	neutral	3.80	23.40	deleterious	0.05	0.35	0.73	disease	0.91	disease	0.65	disease	0.6	disease	2	0.77	neutral	0.58	deleterious	-3	neutral	0.33	neutral	0.37	medium_impact	-0.11	medium_impact	0.59	medium_impact	0.28	0.8	4.32	8.5	0.37	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4752	4752	T	A	MI.13357	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	283	95	S	T	Tca/Aca	-6.88	0	0	benign	0.06	neutral	0.41	neutral	4.54	neutral	-0.81	neutral	-1.9	neutral_impact	0.66	0.9	neutral	0.77	neutral	2.48	19.32	deleterious	0.28	0.45	0.41	neutral	0.63	disease	0.27	neutral	0.24	neutral	5	0.55	neutral	0.68	deleterious	-6	neutral	0.21	neutral	0.3	medium_impact	0.12	medium_impact	-0.59	medium_impact	0.48	0.8	4.32	8.5	0.39	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4752	4752	T	G	MI.13358	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	283	95	S	A	Tca/Gca	-6.88	0	0	benign	0.03	neutral	0.52	neutral	4.56	neutral	0.38	neutral	-2.04	low_impact	1.33	0.93	neutral	0.82	neutral	2.47	19.25	deleterious	0.28	0.45	0.33	neutral	0.62	disease	0.32	neutral	0.24	neutral	5	0.44	neutral	0.75	deleterious	-6	neutral	0.18	neutral	0.59	medium_impact	0.23	medium_impact	-0.03	medium_impact	0.39	0.8	4.32	8.5	0.29	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4753	4753	C	T	MI.13359	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	284	95	S	L	tCa/tTa	-1.35	0	0	possibly_damaging	0.54	neutral	0.67	neutral	4.63	neutral	0.74	deleterious	-4.37	neutral_impact	0.76	0.86	neutral	0.89	neutral	3.30	22.90	deleterious	0.09	0.35	0.22	neutral	0.86	disease	0.35	neutral	0.23	neutral	6	0.46	neutral	0.57	deleterious	-3	neutral	0.54	deleterious	-0.86	medium_impact	0.38	medium_impact	-0.51	medium_impact	0.41	0.8	4.32	8.5	0.25	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9153	9153	C	G	MI.1336	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	627	209	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	3.18	deleterious	-4.45	deleterious	-2.66	high_impact	3.94	0.59	damaging	0.59	neutral	3.54	23.10	deleterious	0.29	0.65	NA	NA	0.81	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.28	high_impact	0.70	0.9	48.67	8.76	0.46	N	0.75	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4753	4753	C	G	MI.13360	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	284	95	S	W	tCa/tGa	-1.35	0	0	probably_damaging	0.98	neutral	0.19	neutral	4.54	deleterious	-3.71	deleterious	-5.6	medium_impact	2.68	0.88	neutral	0.42	neutral	4.16	23.80	deleterious	0.06	0.35	0.83	disease	0.91	disease	0.59	disease	0.68	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.81	deleterious	-2.34	low_impact	-0.14	medium_impact	1.11	medium_impact	0.15	0.8	4.32	8.5	0.37	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4755	4755	T	G	MI.13361	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	286	96	L	V	Tta/Gta	-20	0	0	benign	0.26	neutral	0.39	neutral	4.39	neutral	-1.13	neutral	-0.28	low_impact	0.8	0.93	neutral	0.93	neutral	-0.09	1.82	neutral	0.28	0.45	0.73	disease	0.57	disease	0.33	neutral	0.44	neutral	1	0.53	neutral	0.57	deleterious	-6	neutral	0.43	deleterious	-0.38	medium_impact	0.1	medium_impact	-0.47	medium_impact	0.66	0.8	10.09	9.41	0.37	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4755	4755	T	A	MI.13362	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	286	96	L	M	Tta/Ata	-20	0	0	benign	0.17	neutral	0.38	neutral	4.3	deleterious	-3.44	neutral	-0.1	neutral_impact	-0.26	0.93	neutral	0.85	neutral	1.78	14.87	neutral	0.25	0.45	0.73	disease	0.43	neutral	0.3	neutral	0.62	disease	2	0.55	neutral	0.61	deleterious	-6	neutral	0.31	neutral	-0.17	medium_impact	0.09	medium_impact	-1.36	low_impact	0.48	0.8	10.09	9.41	0.41	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4756	4756	T	G	MI.13363	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	287	96	L	W	tTa/tGa	-2.27	0	0	probably_damaging	0.92	neutral	0.05	neutral	4.25	deleterious	-5.13	neutral	-2.34	low_impact	1.78	0.82	neutral	0.44	neutral	2.32	18.29	deleterious	0.05	0.35	0.97	disease	0.76	disease	0.51	disease	0.78	disease	6	0.99	deleterious	0.07	neutral	-2	neutral	0.80	deleterious	-1.77	low_impact	-0.5	medium_impact	0.35	medium_impact	0.33	0.8	10.09	9.41	0.34	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4756	4756	T	C	MI.13364	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	287	96	L	S	tTa/tCa	-2.27	0	0	benign	0.04	neutral	0.35	neutral	4.31	deleterious	-4.14	neutral	-1.46	neutral_impact	0.6	0.91	neutral	0.86	neutral	0.41	6.67	deleterious	0.04	0.35	0.84	disease	0.7	disease	0.36	neutral	0.57	disease	1	0.62	neutral	0.66	deleterious	-6	neutral	0.28	neutral	0.47	medium_impact	0.06	medium_impact	-0.64	medium_impact	0.33	0.8	10.09	9.41	0.34	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4757	4757	A	C	MI.13365	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	288	96	L	F	ttA/ttC	-1.58	0	0	possibly_damaging	0.69	neutral	0.34	neutral	4.45	deleterious	-3.08	neutral	-0.42	low_impact	0.91	0.93	neutral	0.86	neutral	1.14	11.44	neutral	0.19	0.45	0.68	disease	0.62	disease	0.34	neutral	0.44	neutral	1	0.74	neutral	0.33	neutral	-3	neutral	0.66	deleterious	-1.12	low_impact	0.05	medium_impact	-0.38	medium_impact	0.63	0.8	10.09	9.41	0.42	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4757	4757	A	T	MI.13366	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	288	96	L	F	ttA/ttT	-1.58	0	0	possibly_damaging	0.69	neutral	0.34	neutral	4.45	deleterious	-3.08	neutral	-0.42	low_impact	0.91	0.93	neutral	0.86	neutral	1.25	12.02	neutral	0.19	0.45	0.68	disease	0.62	disease	0.34	neutral	0.44	neutral	1	0.74	neutral	0.33	neutral	-3	neutral	0.66	deleterious	-1.12	low_impact	0.05	medium_impact	-0.38	medium_impact	0.63	0.8	10.09	9.41	0.45	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4758	4758	A	G	MI.13367	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	289	97	M	V	Ata/Gta	-9.87	0	0	benign	0.01	neutral	0.54	neutral	4.69	neutral	-0.28	neutral	-0.95	low_impact	0.94	0.94	neutral	0.9	neutral	1.36	12.56	neutral	0.18	0.45	0.67	disease	0.72	disease	0.5	neutral	0.28	neutral	4	0.45	neutral	0.77	deleterious	-6	neutral	0.23	neutral	1.03	medium_impact	0.25	medium_impact	-0.35	medium_impact	0.36	0.8	0.58	8.19	0.25	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4758	4758	A	C	MI.13368	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	289	97	M	L	Ata/Cta	-9.87	0	0	benign	0.02	neutral	1	neutral	4.97	neutral	2.14	neutral	-0.43	neutral_impact	-0.86	0.94	neutral	0.99	neutral	0.36	6.29	deleterious	0.18	0.45	0.51	disease	0.48	neutral	0.4	neutral	0.36	neutral	3	0.02	neutral	0.99	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	1.87	high_impact	-1.87	low_impact	0.38	0.8	0.58	8.19	0.29	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4758	4758	A	T	MI.13369	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	289	97	M	L	Ata/Tta	-9.87	0	0	benign	0.02	neutral	1	neutral	4.97	neutral	2.14	neutral	-0.43	neutral_impact	-0.86	0.94	neutral	0.99	neutral	0.43	6.87	deleterious	0.18	0.45	0.51	disease	0.48	neutral	0.4	neutral	0.36	neutral	3	0.02	neutral	0.99	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	1.87	high_impact	-1.87	low_impact	0.38	0.8	0.58	8.19	0.29	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9154	9154	C	A	MI.1337	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	628	210	Q	K	Caa/Aaa	-2.88	0	0	probably_damaging	0.97	deleterious	0	neutral	2.97	deleterious	-6.06	deleterious	-3.54	high_impact	4.24	0.6	damaging	0.14	damaging	4.04	23.70	deleterious	0.2	0.65	NA	NA	0.93	disease	0.8	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.90	deleterious	-2.19	low_impact	-1.4	low_impact	2.54	high_impact	0.55	0.9	49.56	8.86	0.44	N	0.99	disease_causing	0.92	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4759	4759	T	A	MI.13370	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	290	97	M	K	aTa/aAa	-3.88	0	0	benign	0.16	neutral	0.32	neutral	4.56	deleterious	-3.18	deleterious	-4.25	medium_impact	2.56	0.87	neutral	0.35	neutral	3.91	23.50	deleterious	0.03	0.35	0.78	disease	0.89	disease	0.74	disease	0.75	disease	5	0.62	neutral	0.58	deleterious	-3	neutral	0.54	deleterious	-0.14	medium_impact	0.03	medium_impact	1.01	medium_impact	0.28	0.8	0.58	8.19	0.36	N	0.92	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4759	4759	T	C	MI.13371	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	290	97	M	T	aTa/aCa	-3.88	0	0	benign	0.01	neutral	0.44	neutral	4.59	neutral	-1.71	deleterious	-3.14	neutral_impact	0.8	0.92	neutral	0.95	neutral	1.51	13.35	neutral	0.08	0.35	0.52	disease	0.73	disease	0.5	neutral	0.26	neutral	5	0.55	neutral	0.72	deleterious	-6	neutral	0.23	neutral	1.03	medium_impact	0.15	medium_impact	-0.47	medium_impact	0.14	0.8	0.58	8.19	0.27	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4760	4760	A	C	MI.13372	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	291	97	M	I	atA/atC	3.02	0.14	0	benign	0.01	neutral	0.76	neutral	4.65	neutral	-0.46	neutral	-0.54	neutral_impact	-0.32	0.92	neutral	0.97	neutral	0.74	9.11	deleterious	0.23	0.45	0.59	disease	0.52	disease	0.42	neutral	0.32	neutral	4	0.22	neutral	0.88	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	0.49	medium_impact	-1.41	low_impact	0.38	0.8	0.58	8.19	0.28	N	0.82	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4760	4760	A	T	MI.13373	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	291	97	M	I	atA/atT	3.02	0.14	0	benign	0.01	neutral	0.76	neutral	4.65	neutral	-0.46	neutral	-0.54	neutral_impact	-0.32	0.92	neutral	0.97	neutral	0.80	9.47	deleterious	0.23	0.45	0.59	disease	0.52	disease	0.42	neutral	0.32	neutral	4	0.22	neutral	0.88	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	0.49	medium_impact	-1.41	low_impact	0.38	0.8	0.58	8.19	0.28	N	0.82	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4761	4761	A	C	MI.13374	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	292	98	I	L	Atc/Ctc	-4.35	0	0	benign	0.01	neutral	1	neutral	4.86	neutral	0.81	neutral	0.21	neutral_impact	-0.18	0.82	neutral	0.93	neutral	0.16	4.30	deleterious	0.19	0.45	0.36	neutral	0.28	neutral	0.26	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	1.87	high_impact	-1.3	low_impact	0.47	0.8	6.92	7.93	0.25	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4761	4761	A	T	MI.13375	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	292	98	I	F	Atc/Ttc	-4.35	0	0	benign	0.21	neutral	0.66	neutral	4.45	neutral	-1.32	neutral	-1.69	low_impact	1.17	0.91	neutral	0.87	neutral	1.88	15.47	deleterious	0.12	0.4	0.51	disease	0.67	disease	0.4	neutral	0.22	neutral	6	0.22	neutral	0.73	deleterious	-6	neutral	0.48	deleterious	-0.27	medium_impact	0.37	medium_impact	-0.16	medium_impact	0.48	0.8	6.92	7.93	0.25	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4761	4761	A	G	MI.13376	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	292	98	I	V	Atc/Gtc	-4.35	0	0	benign	0.01	neutral	0.51	neutral	4.45	neutral	-1.29	neutral	-0.24	low_impact	1.32	0.92	neutral	0.97	neutral	-0.10	1.70	neutral	0.25	0.45	0.6	disease	0.4	neutral	0.38	neutral	0.61	disease	2	0.48	neutral	0.75	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.22	medium_impact	-0.03	medium_impact	0.42	0.8	6.92	7.93	0.35	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4762	4762	T	G	MI.13377	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	293	98	I	S	aTc/aGc	-0.43	0	0	benign	0.14	neutral	0.54	neutral	4.35	deleterious	-3.02	deleterious	-2.64	medium_impact	2.4	0.87	neutral	0.51	neutral	2.49	19.39	deleterious	0.03	0.35	0.76	disease	0.74	disease	0.59	disease	0.71	disease	4	0.36	neutral	0.7	deleterious	-3	neutral	0.38	neutral	-0.08	medium_impact	0.25	medium_impact	0.88	medium_impact	0.35	0.8	6.92	7.93	0.23	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4762	4762	T	C	MI.13378	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	293	98	I	T	aTc/aCc	-0.43	0	0	benign	0.01	neutral	0.41	neutral	4.34	deleterious	-3.27	neutral	-2.17	low_impact	1.38	0.91	neutral	0.97	neutral	0.20	4.69	deleterious	0.06	0.35	0.64	disease	0.56	disease	0.4	neutral	0.23	neutral	5	0.58	neutral	0.7	deleterious	-6	neutral	0.22	neutral	1.03	medium_impact	0.12	medium_impact	0.02	medium_impact	0.26	0.8	6.92	7.93	0.35	N	0.28	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4762	4762	T	A	MI.13379	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	293	98	I	N	aTc/aAc	-0.43	0	0	possibly_damaging	0.46	neutral	0.31	neutral	4.31	deleterious	-4.95	deleterious	-3.75	medium_impact	2.94	0.88	neutral	0.43	neutral	4.16	23.80	deleterious	0.06	0.35	0.91	disease	0.76	disease	0.6	disease	0.71	disease	4	0.65	neutral	0.43	neutral	0	NA	0.61	deleterious	-0.73	medium_impact	0.02	medium_impact	1.33	medium_impact	0.37	0.8	6.92	7.93	0.41	N	0.69	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9154	9154	C	G	MI.1338	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	628	210	Q	E	Caa/Gaa	-2.88	0	0	probably_damaging	0.94	deleterious	0	neutral	2.99	deleterious	-6.46	deleterious	-2.65	high_impact	4.59	0.68	neutral	0.16	damaging	3.19	22.70	deleterious	0.2	0.65	NA	NA	0.88	disease	0.77	disease	0.77	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.89	deleterious	-1.89	low_impact	-1.4	low_impact	2.84	high_impact	0.55	0.9	49.56	8.86	0.52	N	0.94	disease_causing	0.85	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4763	4763	C	A	MI.13380	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	294	98	I	M	atC/atA	0.72	0	0	benign	0.01	neutral	0.35	neutral	4.42	neutral	-1.71	neutral	1.23	neutral_impact	-0.09	0.91	neutral	0.93	neutral	-0.89	0.03	neutral	0.17	0.45	0.5	disease	0.33	neutral	0.29	neutral	0.15	neutral	7	0.64	neutral	0.67	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.06	medium_impact	-1.22	low_impact	0.38	0.8	6.92	7.93	0.36	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4763	4763	C	G	MI.13381	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	294	98	I	M	atC/atG	0.72	0	0	benign	0.01	neutral	0.35	neutral	4.42	neutral	-1.71	neutral	1.23	neutral_impact	-0.09	0.91	neutral	0.93	neutral	-1.39	0.00	neutral	0.17	0.45	0.5	disease	0.33	neutral	0.29	neutral	0.15	neutral	7	0.64	neutral	0.67	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.06	medium_impact	-1.22	low_impact	0.38	0.8	6.92	7.93	0.36	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4764	4764	A	G	MI.13382	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	295	99	M	V	Ata/Gta	-5.73	0	0	benign	0	neutral	0.51	neutral	4.76	neutral	0.88	neutral	0.18	neutral_impact	0.32	0.93	neutral	0.77	neutral	-0.36	0.49	neutral	0.21	0.45	0.41	neutral	0.78	disease	0.48	neutral	0.39	neutral	2	0.49	neutral	0.76	deleterious	-6	neutral	0.22	neutral	1.95	medium_impact	0.22	medium_impact	-0.88	medium_impact	0.46	0.8	0.58	7.94	0.24	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4764	4764	A	C	MI.13383	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	295	99	M	L	Ata/Cta	-5.73	0	0	benign	0	neutral	0.75	neutral	4.88	neutral	2.73	neutral	-0.05	neutral_impact	-0.3	0.94	neutral	0.96	neutral	-0.20	1.08	neutral	0.22	0.45	0.36	neutral	0.71	disease	0.46	neutral	0.17	neutral	7	0.25	neutral	0.88	deleterious	-6	neutral	0.21	neutral	1.95	medium_impact	0.47	medium_impact	-1.4	low_impact	0.39	0.8	0.58	7.94	0.27	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4764	4764	A	T	MI.13384	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	295	99	M	L	Ata/Tta	-5.73	0	0	benign	0	neutral	0.75	neutral	4.88	neutral	2.73	neutral	-0.05	neutral_impact	-0.3	0.94	neutral	0.96	neutral	-0.13	1.50	neutral	0.22	0.45	0.36	neutral	0.71	disease	0.46	neutral	0.17	neutral	7	0.25	neutral	0.88	deleterious	-6	neutral	0.21	neutral	1.95	medium_impact	0.47	medium_impact	-1.4	low_impact	0.39	0.8	0.58	7.94	0.28	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4765	4765	T	A	MI.13385	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	296	99	M	K	aTa/aAa	1.18	0	0	benign	0.04	neutral	0.35	neutral	4.59	neutral	-2.53	neutral	-1.36	medium_impact	1.96	0.85	neutral	0.47	neutral	1.91	15.66	deleterious	0.03	0.35	0.82	disease	0.88	disease	0.7	disease	0.7	disease	4	0.62	neutral	0.66	deleterious	-3	neutral	0.33	neutral	0.47	medium_impact	0.06	medium_impact	0.51	medium_impact	0.29	0.8	0.58	7.94	0.28	N	0.55	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4765	4765	T	C	MI.13386	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	296	99	M	T	aTa/aCa	1.18	0	0	benign	0	neutral	0.55	neutral	4.7	neutral	-0.14	neutral	2.88	neutral_impact	-1.7	0.88	neutral	0.93	neutral	-1.80	0.00	neutral	0.11	0.4	0.4	neutral	0.34	neutral	0.39	neutral	0.41	neutral	2	0.45	neutral	0.78	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.26	medium_impact	-2.58	low_impact	0.16	0.8	0.58	7.94	0.26	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4766	4766	A	T	MI.13387	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	297	99	M	I	atA/atT	0.95	0	0	benign	0	neutral	0.47	neutral	4.78	neutral	0.87	neutral	-0.35	neutral_impact	-0.41	0.88	neutral	0.78	neutral	0.33	5.98	deleterious	0.26	0.45	0.53	disease	0.79	disease	0.46	neutral	0.2	neutral	6	0.52	neutral	0.74	deleterious	-6	neutral	0.27	neutral	1.95	medium_impact	0.18	medium_impact	-1.49	low_impact	0.44	0.8	0.58	7.94	0.26	N	0.17	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4766	4766	A	C	MI.13388	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	297	99	M	I	atA/atC	0.95	0	0	benign	0	neutral	0.47	neutral	4.78	neutral	0.87	neutral	-0.35	neutral_impact	-0.41	0.88	neutral	0.78	neutral	0.27	5.44	deleterious	0.26	0.45	0.53	disease	0.79	disease	0.46	neutral	0.2	neutral	6	0.52	neutral	0.74	deleterious	-6	neutral	0.27	neutral	1.95	medium_impact	0.18	medium_impact	-1.49	low_impact	0.44	0.8	0.58	7.94	0.25	N	0.17	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4767	4767	A	C	MI.13389	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	298	100	M	L	Ata/Cta	-10.1	0	0.01	benign	0	neutral	1	neutral	4.82	neutral	1.97	neutral	0.07	neutral_impact	-0.25	0.84	neutral	0.99	neutral	-1.24	0.01	neutral	0.25	0.45	0.59	disease	0.65	disease	0.4	neutral	0.31	neutral	4	0	neutral	1	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	1.87	high_impact	-1.36	low_impact	0.47	0.8	0.58	8.47	0.31	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9155	9155	A	C	MI.1339	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	629	210	Q	P	cAa/cCa	7.3	1	0	probably_damaging	0.98	deleterious	0	neutral	2.92	deleterious	-8.64	deleterious	-5.34	high_impact	4.24	0.53	damaging	0.15	damaging	3.49	23.10	deleterious	0.14	0.65	NA	NA	0.93	disease	0.82	disease	0.86	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.94	deleterious	-2.36	low_impact	-1.4	low_impact	2.54	high_impact	0.49	0.9	49.56	8.86	0.46	N	0.98	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4767	4767	A	G	MI.13390	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	298	100	M	V	Ata/Gta	-10.1	0	0.01	benign	0	neutral	0.33	neutral	4.84	neutral	2.33	neutral	-0.18	low_impact	0.98	0.94	neutral	0.96	neutral	-0.56	0.15	neutral	0.21	0.45	0.37	neutral	0.72	disease	0.45	neutral	0.24	neutral	5	0.67	neutral	0.67	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.04	medium_impact	-0.32	medium_impact	0.48	0.8	0.58	8.47	0.32	N	0.32	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4767	4767	A	T	MI.13391	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	298	100	M	L	Ata/Tta	-10.1	0	0.01	benign	0	neutral	1	neutral	4.82	neutral	1.97	neutral	0.07	neutral_impact	-0.25	0.84	neutral	0.99	neutral	-1.17	0.01	neutral	0.25	0.45	0.59	disease	0.65	disease	0.4	neutral	0.31	neutral	4	0	neutral	1	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	1.87	high_impact	-1.36	low_impact	0.47	0.8	0.58	8.47	0.31	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4768	4768	T	C	MI.13392	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	299	100	M	T	aTa/aCa	-4.58	0	0	benign	0	neutral	0.36	neutral	4.61	neutral	-0.25	neutral	-2.01	neutral_impact	0.66	0.94	neutral	0.99	neutral	-0.46	0.27	neutral	0.09	0.35	0.45	neutral	0.59	disease	0.44	neutral	0.24	neutral	5	0.64	neutral	0.68	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.07	medium_impact	-0.59	medium_impact	0.19	0.8	0.58	8.47	0.31	N	0.03	polymorphism	1	0.04	rs878853032	Uncertain_significance	not_provided	237098	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4768	4768	T	A	MI.13393	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	299	100	M	K	aTa/aAa	-4.58	0	0	benign	0.04	neutral	0.23	neutral	4.54	neutral	-2.11	deleterious	-3.68	medium_impact	2.73	0.87	neutral	0.38	neutral	2.21	17.55	deleterious	0.03	0.35	0.77	disease	0.89	disease	0.7	disease	0.77	disease	5	0.75	neutral	0.6	deleterious	-3	neutral	0.28	neutral	0.47	medium_impact	-0.08	medium_impact	1.15	medium_impact	0.30	0.8	0.58	8.47	0.35	N	0.62	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4769	4769	A	T	MI.13394	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	300	100	M	I	atA/atT	-0.66	0	0.27	benign	0	neutral	0.56	neutral	4.74	neutral	2.14	neutral	0.2	neutral_impact	-0.24	0.9	neutral	0.98	neutral	-1.22	0.01	neutral	0.2	0.45	0.37	neutral	0.64	disease	0.35	neutral	0.29	neutral	4	0.44	neutral	0.78	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.27	medium_impact	-1.35	low_impact	0.50	0.8	0.58	8.47	0.31	N	0.12	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4769	4769	A	C	MI.13395	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	300	100	M	I	atA/atC	-0.66	0	0.27	benign	0	neutral	0.56	neutral	4.74	neutral	2.14	neutral	0.2	neutral_impact	-0.24	0.9	neutral	0.98	neutral	-1.39	0.00	neutral	0.2	0.45	0.37	neutral	0.64	disease	0.35	neutral	0.29	neutral	4	0.44	neutral	0.78	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.27	medium_impact	-1.35	low_impact	0.50	0.8	0.58	8.47	0.31	N	0.12	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4770	4770	G	T	MI.13396	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	301	101	A	S	Gct/Tct	-20	0	0	probably_damaging	1	neutral	0.45	neutral	4.33	neutral	-2.39	neutral	-2.37	low_impact	1.18	0.89	neutral	0.78	neutral	2.27	17.99	deleterious	0.15	0.4	0.64	disease	0.75	disease	0.41	neutral	0.2	neutral	6	1	deleterious	0.23	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	0.16	medium_impact	-0.15	medium_impact	0.38	0.8	0.29	6.81	0.33	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4770	4770	G	A	MI.13397	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	301	101	A	T	Gct/Act	-20	0	0	probably_damaging	1	neutral	0.41	neutral	4.24	deleterious	-3.12	deleterious	-3.51	medium_impact	2.48	0.93	neutral	0.15	damaging	4.05	23.70	deleterious	0.06	0.35	0.62	disease	0.83	disease	0.58	disease	0.66	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.12	medium_impact	0.94	medium_impact	0.65	0.8	0.29	6.81	0.34	N	0.71	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4770	4770	G	C	MI.13398	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	301	101	A	P	Gct/Cct	-20	0	0	probably_damaging	1	neutral	0.24	neutral	4.18	deleterious	-5.21	deleterious	-4.57	medium_impact	3.2	0.9	neutral	0.15	damaging	3.66	23.20	deleterious	0.03	0.35	0.92	disease	0.86	disease	0.75	disease	0.61	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.07	medium_impact	1.55	medium_impact	0.30	0.8	0.29	6.81	0.4	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4771	4771	C	T	MI.13399	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	302	101	A	V	gCt/gTt	3.48	1	0	probably_damaging	1	neutral	0.55	neutral	4.21	neutral	-2.78	deleterious	-3.78	high_impact	3.54	0.84	neutral	0.12	damaging	4.24	23.90	deleterious	0.05	0.35	0.66	disease	0.86	disease	0.64	disease	0.67	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.26	medium_impact	1.84	medium_impact	0.52	0.8	0.29	6.81	0.43	N	0.80	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8588	8588	T	G	MI.134	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	62	21	V	G	gTa/gGa	-2.42	0	0	possibly_damaging	0.83	neutral	0.12	neutral	4.23	neutral	-2.96	deleterious	-3.43	neutral_impact	0.22	0.84	neutral	0.73	neutral	2.28	18.03	deleterious	0.23	0.65	0.48	neutral	0.32	neutral	0.46	neutral	0.42	neutral	2	0.93	neutral	0.15	neutral	-3	neutral	0.63	deleterious	-1.41	low_impact	-0.2	medium_impact	-0.91	medium_impact	0.50	0.9	22.57	20.88	0.4	N	0.84	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9155	9155	A	G	MI.1340	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	629	210	Q	R	cAa/cGa	7.3	1	0	probably_damaging	0.97	deleterious	0	neutral	2.95	deleterious	-6.4	deleterious	-3.54	high_impact	4.59	0.59	damaging	0.14	damaging	3.54	23.10	deleterious	0.21	0.65	NA	NA	0.93	disease	0.81	disease	0.84	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.92	deleterious	-2.19	low_impact	-1.4	low_impact	2.84	high_impact	0.48	0.9	49.56	8.86	0.53	P	0.91	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4771	4771	C	A	MI.13400	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	302	101	A	D	gCt/gAt	3.48	1	0	probably_damaging	1	neutral	0.21	neutral	4.18	deleterious	-5.27	deleterious	-5.36	high_impact	3.54	0.88	neutral	0.12	damaging	4.43	24.20	deleterious	0.02	0.35	0.95	disease	0.91	disease	0.74	disease	0.61	disease	2	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.11	medium_impact	1.84	medium_impact	0.25	0.8	0.29	6.81	0.54	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4771	4771	C	G	MI.13401	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	302	101	A	G	gCt/gGt	3.48	1	0	probably_damaging	1	neutral	0.4	neutral	4.53	neutral	1.76	deleterious	-3.6	medium_impact	1.97	0.87	neutral	0.15	damaging	3.79	23.40	deleterious	0.11	0.4	0.45	neutral	0.76	disease	0.49	neutral	0.4	neutral	2	1	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.11	medium_impact	0.51	medium_impact	0.58	0.8	0.29	6.81	0.44	N	0.51	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4773	4773	A	G	MI.13402	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	304	102	M	V	Ata/Gta	-10.33	0	0	benign	0.02	neutral	0.25	neutral	4.74	neutral	1.08	neutral	-1.31	low_impact	1.04	0.89	neutral	0.69	neutral	0.82	9.58	deleterious	0.16	0.45	0.43	neutral	0.77	disease	0.59	disease	0.47	neutral	1	0.74	neutral	0.62	deleterious	-6	neutral	0.23	neutral	0.75	medium_impact	-0.06	medium_impact	-0.27	medium_impact	0.29	0.8	0.58	6.92	0.31	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4773	4773	A	T	MI.13403	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	304	102	M	L	Ata/Tta	-10.33	0	0	benign	0	neutral	1	neutral	4.98	neutral	2.46	neutral	1.15	neutral_impact	-1.51	0.9	neutral	0.96	neutral	-1.23	0.01	neutral	0.2	0.45	0.54	disease	0.43	neutral	0.33	neutral	0.55	disease	1	0	neutral	1	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	1.87	high_impact	-2.42	low_impact	0.27	0.8	0.58	6.92	0.29	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4773	4773	A	C	MI.13404	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	304	102	M	L	Ata/Cta	-10.33	0	0	benign	0	neutral	1	neutral	4.98	neutral	2.46	neutral	1.15	neutral_impact	-1.51	0.9	neutral	0.96	neutral	-1.38	0.00	neutral	0.2	0.45	0.54	disease	0.43	neutral	0.33	neutral	0.55	disease	1	0	neutral	1	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	1.87	high_impact	-2.42	low_impact	0.27	0.8	0.58	6.92	0.29	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4774	4774	T	A	MI.13405	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	305	102	M	K	aTa/aAa	-0.43	0	0	benign	0.2	neutral	0.1	neutral	4.63	neutral	-1.97	deleterious	-4.16	medium_impact	2.37	0.83	neutral	0.47	neutral	2.03	16.39	deleterious	0.03	0.35	0.75	disease	0.87	disease	0.67	disease	0.76	disease	5	0.88	neutral	0.45	neutral	-3	neutral	0.53	deleterious	-0.25	medium_impact	-0.32	medium_impact	0.85	medium_impact	0.16	0.8	0.58	6.92	0.32	N	0.59	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4774	4774	T	C	MI.13406	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	305	102	M	T	aTa/aCa	-0.43	0	0	benign	0.1	neutral	0.11	neutral	4.66	neutral	-0.55	deleterious	-3.31	medium_impact	2.02	0.84	neutral	0.61	neutral	0.99	10.61	neutral	0.06	0.35	0.49	neutral	0.7	disease	0.59	disease	0.67	disease	3	0.88	neutral	0.51	deleterious	-3	neutral	0.31	neutral	0.08	medium_impact	-0.3	medium_impact	0.56	medium_impact	0.13	0.8	0.58	6.92	0.34	N	0.50	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4775	4775	A	T	MI.13407	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	306	102	M	I	atA/atT	5.78	0.87	0	benign	0.01	neutral	0.26	neutral	4.69	neutral	1.2	neutral	-0.5	neutral_impact	-0.04	0.82	neutral	0.69	neutral	1.48	13.20	neutral	0.2	0.45	0.35	neutral	0.57	disease	0.38	neutral	0.22	neutral	6	0.73	neutral	0.63	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	-0.04	medium_impact	-1.18	low_impact	0.34	0.8	0.58	6.92	0.44	N	0.10	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4775	4775	A	C	MI.13408	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	306	102	M	I	atA/atC	5.78	0.87	0	benign	0.01	neutral	0.26	neutral	4.69	neutral	1.2	neutral	-0.5	neutral_impact	-0.04	0.82	neutral	0.69	neutral	1.39	12.71	neutral	0.2	0.45	0.35	neutral	0.57	disease	0.38	neutral	0.22	neutral	6	0.73	neutral	0.63	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	-0.04	medium_impact	-1.18	low_impact	0.34	0.8	0.58	6.92	0.43	N	0.10	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4776	4776	G	A	MI.13409	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	307	103	A	T	Gca/Aca	-6.19	0	0	benign	0.02	neutral	0.4	neutral	4.52	deleterious	-3.01	neutral	-0.44	low_impact	1.53	0.9	neutral	0.93	neutral	0.58	7.98	deleterious	0.17	0.45	0.66	disease	0.75	disease	0.36	neutral	0.21	neutral	6	0.58	neutral	0.69	deleterious	-6	neutral	0.26	neutral	0.75	medium_impact	0.11	medium_impact	0.14	medium_impact	0.70	0.85	4.03	8.64	0.32	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9155	9155	A	T	MI.1341	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	629	210	Q	L	cAa/cTa	7.3	1	0	probably_damaging	0.97	deleterious	0	neutral	2.92	deleterious	-7.61	deleterious	-6.19	high_impact	4.59	0.63	neutral	0.13	damaging	3.94	23.50	deleterious	0.15	0.65	NA	NA	0.95	disease	0.74	disease	0.85	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.90	deleterious	-2.19	low_impact	-1.4	low_impact	2.84	high_impact	0.35	0.9	49.56	8.86	0.47	N	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4776	4776	G	C	MI.13410	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	307	103	A	P	Gca/Cca	-6.19	0	0	possibly_damaging	0.85	neutral	0.21	neutral	4.47	deleterious	-5.47	deleterious	-2.77	medium_impact	3.37	0.81	neutral	0.31	neutral	3.57	23.10	deleterious	0.04	0.35	0.9	disease	0.9	disease	0.7	disease	0.63	disease	3	0.91	neutral	0.18	neutral	0	NA	0.82	deleterious	-1.49	low_impact	-0.11	medium_impact	1.69	medium_impact	0.56	0.8	4.03	8.64	0.38	N	0.90	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4776	4776	G	T	MI.13411	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	307	103	A	S	Gca/Tca	-6.19	0	0	benign	0.33	neutral	0.45	neutral	4.51	deleterious	-3.1	neutral	-0.98	low_impact	1.15	0.76	neutral	0.92	neutral	0.59	8.07	deleterious	0.25	0.45	0.6	disease	0.67	disease	0.35	neutral	0.21	neutral	6	0.47	neutral	0.56	deleterious	-6	neutral	0.50	deleterious	-0.52	medium_impact	0.16	medium_impact	-0.18	medium_impact	0.40	0.8	4.03	8.64	0.31	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4777	4777	C	G	MI.13412	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	308	103	A	G	gCa/gGa	-2.96	0	0	possibly_damaging	0.53	neutral	0.38	neutral	4.54	neutral	-0.69	deleterious	-2.78	medium_impact	2.12	0.89	neutral	0.78	neutral	0.93	10.27	neutral	0.2	0.45	0.81	disease	0.79	disease	0.45	neutral	0.46	neutral	1	0.61	neutral	0.43	neutral	0	NA	0.66	deleterious	-0.84	medium_impact	0.09	medium_impact	0.64	medium_impact	0.64	0.8	4.03	8.64	0.37	N	0.48	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4777	4777	C	T	MI.13413	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	308	103	A	V	gCa/gTa	-2.96	0	0	benign	0.04	neutral	0.54	neutral	4.6	neutral	-2.19	neutral	-0.81	low_impact	1.57	0.9	neutral	0.88	neutral	1.43	12.93	neutral	0.13	0.4	0.38	neutral	0.86	disease	0.57	disease	0.4	neutral	2	0.41	neutral	0.75	deleterious	-6	neutral	0.25	neutral	0.47	medium_impact	0.25	medium_impact	0.18	medium_impact	0.58	0.8	4.03	8.64	0.25	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4777	4777	C	A	MI.13414	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	308	103	A	E	gCa/gAa	-2.96	0	0	possibly_damaging	0.66	neutral	0.27	neutral	4.47	deleterious	-5.14	deleterious	-2.69	medium_impact	3.02	0.89	neutral	0.41	neutral	4.08	23.70	deleterious	0.04	0.35	0.88	disease	0.89	disease	0.68	disease	0.64	disease	3	0.77	neutral	0.31	neutral	0	NA	0.73	deleterious	-1.06	low_impact	-0.03	medium_impact	1.4	medium_impact	0.33	0.8	4.03	8.64	0.4	N	0.88	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4779	4779	A	T	MI.13415	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	310	104	M	L	Ata/Tta	-6.65	0	0	benign	0.01	neutral	1	neutral	4.8	neutral	1.03	deleterious	-2.71	low_impact	1.1	0.84	neutral	0.54	neutral	2.10	16.88	deleterious	0.3	0.45	0.54	disease	0.68	disease	0.47	neutral	0.19	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	1.87	high_impact	-0.22	medium_impact	0.41	0.8	NA	NA	0.17	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4779	4779	A	C	MI.13416	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	310	104	M	L	Ata/Cta	-6.65	0	0	benign	0.01	neutral	1	neutral	4.8	neutral	1.03	deleterious	-2.71	low_impact	1.1	0.84	neutral	0.54	neutral	1.95	15.91	deleterious	0.3	0.45	0.54	disease	0.68	disease	0.47	neutral	0.19	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	1.87	high_impact	-0.22	medium_impact	0.41	0.8	NA	NA	0.17	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4779	4779	A	G	MI.13417	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	310	104	M	V	Ata/Gta	-6.65	0	0	benign	0.27	neutral	0.33	neutral	4.85	neutral	1.92	deleterious	-3.6	medium_impact	2.26	0.94	neutral	0.59	neutral	2.59	20.20	deleterious	0.31	0.45	0.48	neutral	0.87	disease	0.61	disease	0.68	disease	4	0.6	neutral	0.53	deleterious	-3	neutral	0.51	deleterious	-0.4	medium_impact	0.04	medium_impact	0.76	medium_impact	0.38	0.8	NA	NA	0.33	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4780	4780	T	C	MI.13418	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	311	104	M	T	aTa/aCa	3.94	0.99	0	benign	0.03	neutral	0.29	neutral	4.71	neutral	1.44	deleterious	-5.61	medium_impact	1.97	0.93	neutral	0.69	neutral	2.82	21.50	deleterious	0.09	0.35	0.65	disease	0.85	disease	0.61	disease	0.54	disease	1	0.69	neutral	0.63	deleterious	-3	neutral	0.33	neutral	0.59	medium_impact	-0.01	medium_impact	0.51	medium_impact	0.16	0.8	NA	NA	0.48	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4780	4780	T	A	MI.13419	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	311	104	M	K	aTa/aAa	3.94	0.99	0	possibly_damaging	0.53	neutral	0.36	neutral	4.6	neutral	-1.75	deleterious	-5.7	medium_impact	3.42	0.82	neutral	0.41	neutral	3.93	23.50	deleterious	0.03	0.35	0.86	disease	0.93	disease	0.73	disease	0.67	disease	3	0.63	neutral	0.42	neutral	0	NA	0.72	deleterious	-0.84	medium_impact	0.07	medium_impact	1.73	medium_impact	0.17	0.8	NA	NA	0.59	P	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9156	9156	A	C	MI.1342	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	630	210	Q	H	caA/caC	8.69	1	0	probably_damaging	1	deleterious	0.03	neutral	2.92	deleterious	-8.14	deleterious	-4.42	high_impact	4.24	0.63	neutral	0.13	damaging	3.59	23.20	deleterious	0.24	0.65	NA	NA	0.89	disease	0.82	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.92	deleterious	-3.6	low_impact	-0.56	medium_impact	2.54	high_impact	0.55	0.9	49.56	8.86	0.47	N	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4781	4781	A	T	MI.13420	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	312	104	M	I	atA/atT	5.78	1	0	benign	0.27	neutral	0.47	neutral	4.8	neutral	1.83	deleterious	-3.56	low_impact	1.54	0.9	neutral	0.94	neutral	1.98	16.08	deleterious	0.26	0.45	0.4	neutral	0.82	disease	0.48	neutral	0.16	neutral	7	0.43	neutral	0.6	deleterious	-6	neutral	0.49	deleterious	-0.4	medium_impact	0.18	medium_impact	0.15	medium_impact	0.33	0.8	NA	NA	0.58	P	0.93	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4781	4781	A	C	MI.13421	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	312	104	M	I	atA/atC	5.78	1	0	benign	0.27	neutral	0.47	neutral	4.8	neutral	1.83	deleterious	-3.56	low_impact	1.54	0.9	neutral	0.94	neutral	1.90	15.59	deleterious	0.26	0.45	0.4	neutral	0.82	disease	0.48	neutral	0.16	neutral	7	0.43	neutral	0.6	deleterious	-6	neutral	0.49	deleterious	-0.4	medium_impact	0.18	medium_impact	0.15	medium_impact	0.33	0.8	NA	NA	0.58	P	0.93	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4782	4782	A	G	MI.13422	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	313	105	K	E	Aaa/Gaa	-1.12	0	0	probably_damaging	1	neutral	0.27	neutral	3.17	deleterious	-7.64	deleterious	-3.87	high_impact	4.15	0.72	neutral	0.07	damaging	3.92	23.50	deleterious	0.06	0.35	0.85	disease	0.77	disease	0.79	disease	0.68	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.03	medium_impact	2.35	high_impact	0.30	0.8	NA	NA	0.44	N	0.91	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4782	4782	A	C	MI.13423	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	313	105	K	Q	Aaa/Caa	-1.12	0	0	probably_damaging	1	neutral	0.29	neutral	3.17	deleterious	-7.91	deleterious	-3.87	high_impact	4.15	0.67	neutral	0.06	damaging	3.34	22.90	deleterious	0.09	0.35	0.85	disease	0.71	disease	0.77	disease	0.68	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	-0.01	medium_impact	2.35	high_impact	0.36	0.8	NA	NA	0.44	N	0.88	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4783	4783	A	C	MI.13424	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	314	105	K	T	aAa/aCa	8.55	1	0	probably_damaging	1	neutral	0.39	neutral	3.15	deleterious	-9.09	deleterious	-5.8	high_impact	4.15	0.73	neutral	0.1	damaging	3.47	23.00	deleterious	0.06	0.35	0.61	disease	0.77	disease	0.77	disease	0.69	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.1	medium_impact	2.35	high_impact	0.20	0.8	NA	NA	0.64	P	0.81	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4783	4783	A	T	MI.13425	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	314	105	K	M	aAa/aTa	8.55	1	0	probably_damaging	1	neutral	0.24	neutral	3.13	deleterious	-10.66	deleterious	-5.8	high_impact	4.15	0.7	neutral	0.04	damaging	3.70	23.30	deleterious	0.05	0.35	0.59	disease	0.78	disease	0.77	disease	0.69	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	-0.07	medium_impact	2.35	high_impact	0.17	0.8	NA	NA	0.61	P	0.45	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4784	4784	A	T	MI.13426	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	315	105	K	N	aaA/aaT	8.55	1	0	probably_damaging	1	neutral	0.31	neutral	3.18	deleterious	-8.51	deleterious	-4.84	high_impact	3.8	0.66	neutral	0.04	damaging	3.72	23.30	deleterious	0.09	0.35	0.75	disease	0.71	disease	0.76	disease	0.69	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.02	medium_impact	2.05	high_impact	0.20	0.8	NA	NA	0.63	P	0.69	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4784	4784	A	C	MI.13427	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	315	105	K	N	aaA/aaC	8.55	1	0	probably_damaging	1	neutral	0.31	neutral	3.18	deleterious	-8.51	deleterious	-4.84	high_impact	3.8	0.66	neutral	0.04	damaging	3.67	23.30	deleterious	0.09	0.35	0.75	disease	0.71	disease	0.76	disease	0.69	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.02	medium_impact	2.05	high_impact	0.20	0.8	NA	NA	0.63	P	0.69	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4785	4785	C	A	MI.13428	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	316	106	L	M	Cta/Ata	4.63	1	0	possibly_damaging	0.71	neutral	0.29	neutral	4.45	neutral	-1.58	neutral	-1.44	low_impact	1.5	0.94	neutral	0.19	damaging	3.73	23.30	deleterious	0.39	0.5	0.77	disease	0.7	disease	0.36	neutral	0.22	neutral	6	0.78	neutral	0.29	neutral	-3	neutral	0.71	deleterious	-1.15	low_impact	-0.01	medium_impact	0.12	medium_impact	0.63	0.8	0.29	7.5	0.55	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4785	4785	C	G	MI.13429	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	316	106	L	V	Cta/Gta	4.63	1	0	possibly_damaging	0.87	neutral	0.54	neutral	4.48	neutral	-0.21	deleterious	-2.7	medium_impact	2.37	0.86	neutral	0.16	damaging	3.25	22.80	deleterious	0.28	0.45	0.67	disease	0.77	disease	0.52	disease	0.2	neutral	6	0.85	neutral	0.34	neutral	0	NA	0.76	deleterious	-1.55	low_impact	0.25	medium_impact	0.85	medium_impact	0.54	0.8	0.29	7.5	0.48	N	0.77	polymorphism	1	0.05	rs28613328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9156	9156	A	T	MI.1343	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	630	210	Q	H	caA/caT	8.69	1	0	probably_damaging	1	deleterious	0.03	neutral	2.92	deleterious	-8.14	deleterious	-4.42	high_impact	4.24	0.63	neutral	0.13	damaging	3.73	23.30	deleterious	0.24	0.65	NA	NA	0.89	disease	0.82	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.92	deleterious	-3.6	low_impact	-0.56	medium_impact	2.54	high_impact	0.55	0.9	49.56	8.86	0.49	N	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4786	4786	T	C	MI.13430	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	317	106	L	P	cTa/cCa	-0.66	0.22	0	probably_damaging	0.99	neutral	0.28	neutral	4.37	deleterious	-4.65	deleterious	-6.47	high_impact	3.56	0.84	neutral	0.08	damaging	3.88	23.50	deleterious	0.03	0.35	0.97	disease	0.87	disease	0.76	disease	0.65	disease	3	0.99	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-2.62	low_impact	-0.02	medium_impact	1.85	medium_impact	0.25	0.8	0.29	7.5	0.37	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4786	4786	T	A	MI.13431	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	317	106	L	Q	cTa/cAa	-0.66	0.22	0	probably_damaging	0.99	neutral	0.26	neutral	4.38	deleterious	-4.32	deleterious	-5.41	high_impact	3.91	0.85	neutral	0.11	damaging	4.29	24.00	deleterious	0.04	0.35	0.96	disease	0.84	disease	0.65	disease	0.67	disease	3	0.99	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-2.62	low_impact	-0.04	medium_impact	2.15	high_impact	0.24	0.8	0.29	7.5	0.33	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4786	4786	T	G	MI.13432	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	317	106	L	R	cTa/cGa	-0.66	0.22	0	probably_damaging	0.99	neutral	0.31	neutral	4.38	deleterious	-4.17	deleterious	-5.51	high_impact	3.91	0.81	neutral	0.08	damaging	4.13	23.80	deleterious	0.03	0.35	0.95	disease	0.94	disease	0.76	disease	0.64	disease	3	0.99	deleterious	0.16	neutral	2	deleterious	0.91	deleterious	-2.62	low_impact	0.02	medium_impact	2.15	high_impact	0.17	0.8	0.29	7.5	0.38	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4788	4788	G	T	MI.13433	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	319	107	G	W	Gga/Tga	-1.12	0.01	0	probably_damaging	1	neutral	0.19	neutral	4.3	deleterious	-8.97	deleterious	-7.74	high_impact	4.12	0.57	damaging	0.02	damaging	4.29	24.00	deleterious	0.04	0.35	0.42	neutral	0.89	disease	0.72	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	-0.14	medium_impact	2.32	high_impact	0.08	0.8	NA	NA	0.35	N	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4788	4788	G	C	MI.13434	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	319	107	G	R	Gga/Cga	-1.12	0.01	0	probably_damaging	1	neutral	0.36	neutral	4.31	deleterious	-5.91	deleterious	-7.73	high_impact	4.12	0.5	damaging	0.02	damaging	3.78	23.40	deleterious	0.03	0.35	0.84	disease	0.92	disease	0.77	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	0.07	medium_impact	2.32	high_impact	0.56	0.8	NA	NA	0.41	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4789	4789	G	T	MI.13435	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	320	107	G	V	gGa/gTa	6.01	1	0	probably_damaging	1	neutral	0.54	neutral	4.32	deleterious	-4.98	deleterious	-8.7	high_impact	3.77	0.59	damaging	0.02	damaging	3.64	23.20	deleterious	0.03	0.35	0.56	disease	0.9	disease	0.67	disease	0.7	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.25	medium_impact	2.03	high_impact	0.17	0.8	NA	NA	0.52	N	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4789	4789	G	A	MI.13436	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	320	107	G	E	gGa/gAa	6.01	1	0	probably_damaging	1	neutral	0.31	neutral	4.32	deleterious	-5.54	deleterious	-7.73	high_impact	4.12	0.57	damaging	0.02	damaging	3.79	23.40	deleterious	0.03	0.35	0.86	disease	0.86	disease	0.77	disease	0.63	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	0.02	medium_impact	2.32	high_impact	0.20	0.8	NA	NA	0.67	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4789	4789	G	C	MI.13437	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	320	107	G	A	gGa/gCa	6.01	1	0	probably_damaging	1	neutral	0.61	neutral	4.7	neutral	0.57	deleterious	-5.8	medium_impact	2.4	0.66	neutral	0.16	damaging	3.01	22.30	deleterious	0.07	0.35	0.47	neutral	0.64	disease	0.39	neutral	0.18	neutral	7	1	deleterious	0.31	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.32	medium_impact	0.88	medium_impact	0.28	0.8	NA	NA	0.48	N	0.74	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4791	4791	A	G	MI.13438	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	322	108	M	V	Ata/Gta	-5.27	0	0	probably_damaging	0.98	neutral	0.59	neutral	4.68	neutral	0.73	neutral	-2.2	neutral_impact	0.3	0.89	neutral	0.48	neutral	2.50	19.49	deleterious	0.26	0.45	0.35	neutral	0.72	disease	0.32	neutral	0.17	neutral	7	0.98	deleterious	0.31	neutral	-2	neutral	0.74	deleterious	-2.34	low_impact	0.3	medium_impact	-0.89	medium_impact	0.38	0.8	0.86	6.92	0.23	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4791	4791	A	T	MI.13439	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	322	108	M	L	Ata/Tta	-5.27	0	0	probably_damaging	0.96	neutral	0.9	neutral	4.77	neutral	1.72	neutral	-0.26	neutral_impact	-1.3	0.9	neutral	0.96	neutral	0.50	7.39	deleterious	0.32	0.5	0.55	disease	0.33	neutral	0.23	neutral	0.6	disease	2	0.96	neutral	0.47	deleterious	-2	neutral	0.68	deleterious	-2.06	low_impact	0.74	medium_impact	-2.24	low_impact	0.36	0.8	0.86	6.92	0.35	N	0.15	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9157	9157	G	A	MI.1344	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	631	211	A	T	Gcc/Acc	0.82	0.99	0	probably_damaging	1	deleterious	0.03	neutral	2.96	deleterious	-6.06	deleterious	-3.51	medium_impact	3.48	0.77	neutral	0.46	neutral	4.43	24.20	deleterious	0.32	0.65	NA	NA	0.84	disease	0.62	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.87	deleterious	-3.6	low_impact	-0.56	medium_impact	1.89	medium_impact	0.68	0.9	50.44	9.14	0.4	N	0.80	disease_causing	1	0.19	.	not_provided	not_provided	434783	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4791	4791	A	C	MI.13440	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	322	108	M	L	Ata/Cta	-5.27	0	0	probably_damaging	0.96	neutral	0.9	neutral	4.77	neutral	1.72	neutral	-0.26	neutral_impact	-1.3	0.9	neutral	0.96	neutral	0.39	6.52	deleterious	0.32	0.5	0.55	disease	0.33	neutral	0.23	neutral	0.6	disease	2	0.96	neutral	0.47	deleterious	-2	neutral	0.68	deleterious	-2.06	low_impact	0.74	medium_impact	-2.24	low_impact	0.36	0.8	0.86	6.92	0.35	N	0.15	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4792	4792	T	A	MI.13441	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	323	108	M	K	aTa/aAa	-1.58	0	0	probably_damaging	0.99	neutral	0.38	neutral	4.57	neutral	-2.65	deleterious	-4.71	medium_impact	2.23	0.81	neutral	0.17	damaging	4.12	23.80	deleterious	0.03	0.35	0.79	disease	0.87	disease	0.67	disease	0.75	disease	5	0.99	deleterious	0.2	neutral	1	deleterious	0.86	deleterious	-2.62	low_impact	0.09	medium_impact	0.73	medium_impact	0.17	0.8	0.86	6.92	0.23	N	0.93	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4792	4792	T	C	MI.13442	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	323	108	M	T	aTa/aCa	-1.58	0	0	probably_damaging	0.99	neutral	0.44	neutral	4.63	neutral	-1.23	deleterious	-4.16	neutral_impact	0.61	0.9	neutral	0.31	neutral	2.84	21.60	deleterious	0.15	0.4	0.51	disease	0.72	disease	0.57	disease	0.68	disease	4	0.99	deleterious	0.23	neutral	-2	neutral	0.79	deleterious	-2.62	low_impact	0.15	medium_impact	-0.63	medium_impact	0.18	0.8	0.86	6.92	0.33	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4793	4793	A	T	MI.13443	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	324	108	M	I	atA/atT	4.63	0.69	0.11	probably_damaging	0.98	neutral	0.45	neutral	4.73	neutral	0.42	neutral	-1.7	neutral_impact	0.28	0.84	neutral	0.35	neutral	3.35	22.90	deleterious	0.37	0.5	0.41	neutral	0.77	disease	0.29	neutral	0.18	neutral	6	0.98	deleterious	0.24	neutral	-2	neutral	0.78	deleterious	-2.34	low_impact	0.16	medium_impact	-0.91	medium_impact	0.40	0.8	0.86	6.92	0.33	N	0.52	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4793	4793	A	C	MI.13444	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	324	108	M	I	atA/atC	4.63	0.69	0.11	probably_damaging	0.98	neutral	0.45	neutral	4.73	neutral	0.42	neutral	-1.7	neutral_impact	0.28	0.84	neutral	0.35	neutral	3.18	22.70	deleterious	0.37	0.5	0.41	neutral	0.77	disease	0.29	neutral	0.18	neutral	6	0.98	deleterious	0.24	neutral	-2	neutral	0.78	deleterious	-2.34	low_impact	0.16	medium_impact	-0.91	medium_impact	0.40	0.8	0.86	6.92	0.32	N	0.52	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4794	4794	G	A	MI.13445	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	325	109	A	T	Gcc/Acc	-1.81	0	0	benign	0.17	neutral	0.4	neutral	4.47	neutral	-2.64	neutral	-2.12	medium_impact	2.58	0.93	neutral	0.85	neutral	4.03	23.60	deleterious	0.15	0.4	0.73	disease	0.76	disease	0.53	disease	0.33	neutral	3	0.52	neutral	0.62	deleterious	-3	neutral	0.53	deleterious	-0.17	medium_impact	0.11	medium_impact	1.03	medium_impact	0.69	0.85	NA	NA	0.32	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4794	4794	G	C	MI.13446	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	325	109	A	P	Gcc/Ccc	-1.81	0	0	probably_damaging	0.98	neutral	0.24	neutral	4.43	deleterious	-4.2	deleterious	-3.79	medium_impact	2.65	0.89	neutral	0.39	neutral	3.66	23.20	deleterious	0.03	0.35	0.96	disease	0.88	disease	0.52	disease	0.62	disease	2	0.98	deleterious	0.13	neutral	1	deleterious	0.90	deleterious	-2.34	low_impact	-0.07	medium_impact	1.09	medium_impact	0.58	0.8	NA	NA	0.42	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4794	4794	G	T	MI.13447	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	325	109	A	S	Gcc/Tcc	-1.81	0	0	possibly_damaging	0.79	neutral	0.41	neutral	4.48	neutral	-2.85	neutral	-1.2	medium_impact	2.56	0.81	neutral	0.94	neutral	2.02	16.34	deleterious	0.17	0.45	0.48	neutral	0.61	disease	0.38	neutral	0.17	neutral	7	0.79	neutral	0.31	neutral	0	NA	0.73	deleterious	-1.32	low_impact	0.12	medium_impact	1.01	medium_impact	0.56	0.8	NA	NA	0.37	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4795	4795	C	T	MI.13448	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	326	109	A	V	gCc/gTc	0.95	0.04	0	possibly_damaging	0.79	neutral	0.53	neutral	4.58	neutral	1.02	deleterious	-3.26	low_impact	1.92	0.84	neutral	0.71	neutral	4.26	23.90	deleterious	0.13	0.4	0.75	disease	0.5	disease	0.41	neutral	0.3	neutral	4	0.77	neutral	0.37	neutral	-3	neutral	0.76	deleterious	-1.32	low_impact	0.24	medium_impact	0.47	medium_impact	0.70	0.85	NA	NA	0.3	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4795	4795	C	A	MI.13449	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	326	109	A	D	gCc/gAc	0.95	0.04	0	probably_damaging	0.97	neutral	0.2	neutral	4.42	deleterious	-5.21	deleterious	-4.22	high_impact	3.94	0.84	neutral	0.35	neutral	4.51	24.30	deleterious	0.02	0.35	0.97	disease	0.9	disease	0.72	disease	0.64	disease	3	0.98	neutral	0.12	neutral	2	deleterious	0.88	deleterious	-2.18	low_impact	-0.13	medium_impact	2.17	high_impact	0.41	0.8	NA	NA	0.43	N	0.96	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9157	9157	G	C	MI.1345	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	631	211	A	P	Gcc/Ccc	0.82	0.99	0	probably_damaging	1	deleterious	0	neutral	2.94	deleterious	-7.69	deleterious	-4.46	high_impact	3.58	0.71	neutral	0.45	neutral	3.97	23.60	deleterious	0.17	0.65	NA	NA	0.93	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.6	low_impact	-1.4	low_impact	1.97	medium_impact	0.63	0.9	50.44	9.14	0.36	N	0.97	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4795	4795	C	G	MI.13450	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	326	109	A	G	gCc/gGc	0.95	0.04	0	possibly_damaging	0.88	neutral	0.35	neutral	4.44	deleterious	-3.71	deleterious	-3.02	medium_impact	2.84	0.89	neutral	0.52	neutral	3.86	23.50	deleterious	0.14	0.4	0.88	disease	0.75	disease	0.6	disease	0.64	disease	3	0.89	neutral	0.24	neutral	0	NA	0.83	deleterious	-1.59	low_impact	0.06	medium_impact	1.25	medium_impact	0.70	0.85	NA	NA	0.42	N	0.61	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4797	4797	C	A	MI.13451	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	328	110	P	T	Ccc/Acc	-5.27	0	0	probably_damaging	1	neutral	0.4	neutral	4.11	deleterious	-8.39	deleterious	-7.73	high_impact	4.15	0.81	neutral	0.08	damaging	3.60	23.20	deleterious	0.03	0.35	0.61	disease	0.85	disease	0.76	disease	0.69	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.11	medium_impact	2.35	high_impact	0.56	0.8	NA	NA	0.36	N	0.88	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4797	4797	C	T	MI.13452	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	328	110	P	S	Ccc/Tcc	-5.27	0	0	probably_damaging	1	neutral	0.45	neutral	4.09	deleterious	-8.04	deleterious	-7.73	high_impact	4.15	0.91	neutral	0.12	damaging	3.78	23.40	deleterious	0.04	0.35	0.48	neutral	0.84	disease	0.73	disease	0.69	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.16	medium_impact	2.35	high_impact	0.17	0.8	NA	NA	0.41	N	0.72	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4797	4797	C	G	MI.13453	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	328	110	P	A	Ccc/Gcc	-5.27	0	0	probably_damaging	1	neutral	0.53	neutral	4.13	deleterious	-7.74	deleterious	-7.73	high_impact	3.81	0.82	neutral	0.13	damaging	2.99	22.20	deleterious	0.05	0.35	0.6	disease	0.73	disease	0.76	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.24	medium_impact	2.06	high_impact	0.61	0.8	NA	NA	0.31	N	0.72	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4798	4798	C	T	MI.13454	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	329	110	P	L	cCc/cTc	5.55	1	0	probably_damaging	1	neutral	0.71	neutral	4.2	deleterious	-9.47	deleterious	-9.67	high_impact	3.81	0.74	neutral	0.08	damaging	4.32	24.00	deleterious	0.02	0.35	0.66	disease	0.86	disease	0.74	disease	0.68	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.42	medium_impact	2.06	high_impact	0.56	0.8	NA	NA	0.56	P	0.97	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4798	4798	C	G	MI.13455	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	329	110	P	R	cCc/cGc	5.55	1	0	probably_damaging	1	neutral	0.35	neutral	4.07	deleterious	-10.42	deleterious	-8.7	high_impact	4.15	0.83	neutral	0.08	damaging	3.52	23.10	deleterious	0.02	0.35	0.57	disease	0.92	disease	0.83	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	0.06	medium_impact	2.35	high_impact	0.33	0.8	NA	NA	0.61	P	0.56	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4798	4798	C	A	MI.13456	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	329	110	P	H	cCc/cAc	5.55	1	0	probably_damaging	1	neutral	0.57	neutral	4.06	deleterious	-11.4	deleterious	-8.7	high_impact	4.15	0.81	neutral	0.08	damaging	3.95	23.60	deleterious	0.03	0.35	0.71	disease	0.86	disease	0.83	disease	0.71	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.28	medium_impact	2.35	high_impact	0.31	0.8	NA	NA	0.62	P	0.71	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4800	4800	T	G	MI.13457	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	331	111	F	V	Ttt/Gtt	-6.88	0	0	possibly_damaging	0.77	neutral	0.58	neutral	4.32	neutral	-2.74	deleterious	-6.5	medium_impact	2.01	0.91	neutral	0.17	damaging	3.97	23.60	deleterious	0.06	0.35	0.73	disease	0.86	disease	0.55	disease	0.31	neutral	4	0.73	neutral	0.41	neutral	0	NA	0.74	deleterious	-1.28	low_impact	0.29	medium_impact	0.55	medium_impact	0.39	0.8	0.58	7.14	0.27	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4800	4800	T	A	MI.13458	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	331	111	F	I	Ttt/Att	-6.88	0	0	possibly_damaging	0.77	neutral	0.45	neutral	4.28	deleterious	-3.68	deleterious	-5.53	medium_impact	2.21	0.86	neutral	0.15	damaging	4.26	23.90	deleterious	0.09	0.35	0.78	disease	0.88	disease	0.67	disease	0.67	disease	3	0.76	neutral	0.34	neutral	0	NA	0.76	deleterious	-1.28	low_impact	0.16	medium_impact	0.72	medium_impact	0.50	0.8	0.58	7.14	0.31	N	0.93	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4800	4800	T	C	MI.13459	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	331	111	F	L	Ttt/Ctt	-6.88	0	0	benign	0.09	neutral	0.86	neutral	4.74	neutral	-0.93	deleterious	-5.47	low_impact	1.23	0.88	neutral	0.3	neutral	2.75	21.10	deleterious	0.12	0.4	0.67	disease	0.65	disease	0.47	neutral	0.21	neutral	6	0.05	neutral	0.89	deleterious	-6	neutral	0.27	neutral	0.12	medium_impact	0.65	medium_impact	-0.11	medium_impact	0.66	0.8	0.58	7.14	0.21	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9157	9157	G	T	MI.1346	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	631	211	A	S	Gcc/Tcc	0.82	0.99	0	probably_damaging	0.99	neutral	0.51	neutral	3.14	deleterious	-4.86	deleterious	-2.63	medium_impact	2.1	0.76	neutral	0.61	neutral	3.80	23.40	deleterious	0.25	0.65	NA	NA	0.71	disease	0.51	disease	0.5	disease	0	0.99	deleterious	0.26	neutral	1	deleterious	0.87	deleterious	-2.65	low_impact	0.3	medium_impact	0.7	medium_impact	0.73	0.9	50.44	9.14	0.36	N	0.95	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4801	4801	T	C	MI.13460	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	332	111	F	S	tTt/tCt	1.87	0.97	0	probably_damaging	0.96	neutral	0.5	neutral	4.22	deleterious	-4.4	deleterious	-7.53	medium_impact	3.25	0.84	neutral	0.15	damaging	4.07	23.70	deleterious	0.02	0.35	0.5	neutral	0.86	disease	0.69	disease	0.69	disease	4	0.96	neutral	0.27	neutral	1	deleterious	0.78	deleterious	-2.06	low_impact	0.21	medium_impact	1.59	medium_impact	0.29	0.8	0.58	7.14	0.43	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4801	4801	T	G	MI.13461	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	332	111	F	C	tTt/tGt	1.87	0.97	0	probably_damaging	0.99	neutral	0.2	neutral	4.27	deleterious	-5.82	deleterious	-7.5	medium_impact	2.65	0.8	neutral	0.15	damaging	4.02	23.60	deleterious	0.03	0.35	0.92	disease	0.89	disease	0.72	disease	0.62	disease	2	0.99	deleterious	0.11	neutral	1	deleterious	0.83	deleterious	-2.62	low_impact	-0.13	medium_impact	1.09	medium_impact	0.26	0.8	0.58	7.14	0.4	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4801	4801	T	A	MI.13462	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	332	111	F	Y	tTt/tAt	1.87	0.97	0	probably_damaging	0.93	neutral	1	neutral	4.21	deleterious	-5.17	deleterious	-2.83	high_impact	3.8	0.88	neutral	0.13	damaging	4.08	23.70	deleterious	0.13	0.4	0.84	disease	0.81	disease	0.71	disease	0.65	disease	3	0.93	neutral	0.54	deleterious	2	deleterious	0.82	deleterious	-1.83	low_impact	1.87	high_impact	2.05	high_impact	0.64	0.8	0.58	7.14	0.43	N	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4802	4802	T	A	MI.13463	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	333	111	F	L	ttT/ttA	7.4	1	0	benign	0.09	neutral	0.86	neutral	4.74	neutral	-0.93	deleterious	-5.47	low_impact	1.23	0.88	neutral	0.3	neutral	3.18	22.70	deleterious	0.12	0.4	0.67	disease	0.65	disease	0.47	neutral	0.21	neutral	6	0.05	neutral	0.89	deleterious	-6	neutral	0.27	neutral	0.12	medium_impact	0.65	medium_impact	-0.11	medium_impact	0.66	0.8	0.58	7.14	0.52	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4802	4802	T	G	MI.13464	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	333	111	F	L	ttT/ttG	7.4	1	0	benign	0.09	neutral	0.86	neutral	4.74	neutral	-0.93	deleterious	-5.47	low_impact	1.23	0.88	neutral	0.3	neutral	3.10	22.50	deleterious	0.12	0.4	0.67	disease	0.65	disease	0.47	neutral	0.21	neutral	6	0.05	neutral	0.89	deleterious	-6	neutral	0.27	neutral	0.12	medium_impact	0.65	medium_impact	-0.11	medium_impact	0.66	0.8	0.58	7.14	0.5	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4803	4803	C	T	MI.13465	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	334	112	H	Y	Cac/Tac	-3.65	0	0	probably_damaging	1	neutral	1	neutral	4.01	deleterious	-5.55	deleterious	-5.8	medium_impact	2.45	0.62	neutral	0.04	damaging	3.57	23.10	deleterious	0.05	0.35	0.64	disease	0.87	disease	0.81	disease	0.7	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.87	deleterious	-3.54	low_impact	1.87	high_impact	0.92	medium_impact	0.28	0.8	NA	NA	0.26	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4803	4803	C	G	MI.13466	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	334	112	H	D	Cac/Gac	-3.65	0	0	probably_damaging	1	neutral	0.2	neutral	3.98	deleterious	-5.82	deleterious	-8.7	high_impact	4.12	0.64	neutral	0.04	damaging	3.74	23.30	deleterious	0.05	0.35	0.91	disease	0.83	disease	0.84	disease	0.66	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.13	medium_impact	2.32	high_impact	0.28	0.8	NA	NA	0.4	N	0.95	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4803	4803	C	A	MI.13467	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	334	112	H	N	Cac/Aac	-3.65	0	0	probably_damaging	1	neutral	0.31	neutral	4	deleterious	-5.39	deleterious	-6.77	high_impact	4.12	0.64	neutral	0.04	damaging	3.74	23.30	deleterious	0.1	0.4	0.86	disease	0.84	disease	0.8	disease	0.66	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	0.02	medium_impact	2.32	high_impact	0.31	0.8	NA	NA	0.38	N	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4804	4804	A	T	MI.13468	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	335	112	H	L	cAc/cTc	4.4	1	0	probably_damaging	1	neutral	0.65	neutral	3.97	deleterious	-5.65	deleterious	-10.64	high_impact	4.12	0.68	neutral	0.03	damaging	3.68	23.30	deleterious	0.03	0.35	0.65	disease	0.87	disease	0.79	disease	0.7	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.36	medium_impact	2.32	high_impact	0.26	0.8	NA	NA	0.58	P	0.97	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4804	4804	A	C	MI.13469	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	335	112	H	P	cAc/cCc	4.4	1	0	probably_damaging	1	neutral	0.22	neutral	3.95	deleterious	-7.11	deleterious	-9.67	high_impact	3.77	0.61	neutral	0.04	damaging	3.10	22.50	deleterious	0.03	0.35	0.83	disease	0.87	disease	0.79	disease	0.67	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	-0.1	medium_impact	2.03	high_impact	0.18	0.8	NA	NA	0.59	P	0.96	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9158	9158	C	G	MI.1347	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	632	211	A	G	gCc/gGc	7.3	1	0	probably_damaging	0.99	neutral	0.08	neutral	3.02	deleterious	-6.41	deleterious	-3.55	medium_impact	2.34	0.87	neutral	0.61	neutral	4.11	23.70	deleterious	0.28	0.65	NA	NA	0.86	disease	0.53	disease	0.54	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.85	deleterious	-2.65	low_impact	-0.31	medium_impact	0.91	medium_impact	0.80	0.9	50.44	9.14	0.48	N	0.86	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4804	4804	A	G	MI.13470	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	335	112	H	R	cAc/cGc	4.4	1	0	probably_damaging	1	neutral	0.35	neutral	3.99	deleterious	-5.73	deleterious	-7.74	high_impact	4.12	0.64	neutral	0.04	damaging	2.88	21.80	deleterious	0.04	0.35	0.84	disease	0.88	disease	0.82	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.54	low_impact	0.06	medium_impact	2.32	high_impact	0.44	0.8	NA	NA	0.62	P	0.98	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4805	4805	C	A	MI.13471	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	336	112	H	Q	caC/caA	6.94	1	0	probably_damaging	1	neutral	0.29	neutral	4.04	deleterious	-4.43	deleterious	-7.74	medium_impact	3.31	0.66	neutral	0.04	damaging	3.76	23.40	deleterious	0.05	0.35	0.85	disease	0.81	disease	0.81	disease	0.66	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	-0.01	medium_impact	1.64	medium_impact	0.47	0.8	NA	NA	0.62	P	0.94	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4805	4805	C	G	MI.13472	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	336	112	H	Q	caC/caG	6.94	1	0	probably_damaging	1	neutral	0.29	neutral	4.04	deleterious	-4.43	deleterious	-7.74	medium_impact	3.31	0.66	neutral	0.04	damaging	3.49	23.10	deleterious	0.05	0.35	0.85	disease	0.81	disease	0.81	disease	0.66	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	-0.01	medium_impact	1.64	medium_impact	0.47	0.8	NA	NA	0.62	P	0.94	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4806	4806	T	C	MI.13473	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	337	113	F	L	Ttc/Ctc	0.72	0.98	0	probably_damaging	1	neutral	0.79	neutral	4.68	neutral	-1.04	deleterious	-4.73	medium_impact	2.04	0.89	neutral	0.73	neutral	2.99	22.20	deleterious	0.15	0.45	0.49	neutral	0.64	disease	0.51	disease	0.15	neutral	7	1	deleterious	0.4	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.53	medium_impact	0.57	medium_impact	0.68	0.85	NA	NA	0.46	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4806	4806	T	A	MI.13474	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	337	113	F	I	Ttc/Atc	0.72	0.98	0	probably_damaging	1	neutral	0.36	neutral	4.57	neutral	-1.47	deleterious	-4.95	medium_impact	2.96	0.88	neutral	0.14	damaging	4.47	24.20	deleterious	0.13	0.4	0.5	neutral	0.85	disease	0.71	disease	0.69	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.07	medium_impact	1.35	medium_impact	0.47	0.8	NA	NA	0.5	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4806	4806	T	G	MI.13475	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	337	113	F	V	Ttc/Gtc	0.72	0.98	0	probably_damaging	1	neutral	0.39	neutral	4.6	neutral	-0.99	deleterious	-5.91	medium_impact	3.38	0.87	neutral	0.15	damaging	4.06	23.70	deleterious	0.08	0.35	0.56	disease	0.89	disease	0.7	disease	0.7	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.1	medium_impact	1.7	medium_impact	0.28	0.8	NA	NA	0.48	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4807	4807	T	C	MI.13476	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	338	113	F	S	tTc/tCc	1.41	0.98	0	probably_damaging	1	neutral	0.41	neutral	4.53	neutral	-1.58	deleterious	-7.09	medium_impact	2.1	0.91	neutral	0.25	damaging	4.08	23.70	deleterious	0.04	0.35	0.66	disease	0.85	disease	0.66	disease	0.55	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.12	medium_impact	0.62	medium_impact	0.26	0.8	NA	NA	0.49	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4807	4807	T	A	MI.13477	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	338	113	F	Y	tTc/tAc	1.41	0.98	0	probably_damaging	1	neutral	0.78	neutral	4.52	deleterious	-3.27	deleterious	-2.69	medium_impact	2.46	0.92	neutral	0.32	neutral	4.09	23.70	deleterious	0.14	0.4	0.86	disease	0.8	disease	0.65	disease	0.61	disease	2	1	deleterious	0.39	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	0.51	medium_impact	0.93	medium_impact	0.54	0.8	NA	NA	0.44	N	0.45	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4807	4807	T	G	MI.13478	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	338	113	F	C	tTc/tGc	1.41	0.98	0	probably_damaging	1	neutral	0.13	neutral	4.49	deleterious	-4.46	deleterious	-6.99	medium_impact	3.23	0.85	neutral	0.14	damaging	4.01	23.60	deleterious	0.04	0.35	0.94	disease	0.88	disease	0.71	disease	0.63	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.25	medium_impact	1.57	medium_impact	0.21	0.8	NA	NA	0.45	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4808	4808	C	G	MI.13479	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	339	113	F	L	ttC/ttG	1.64	0.95	0	probably_damaging	1	neutral	0.79	neutral	4.68	neutral	-1.04	deleterious	-4.73	medium_impact	2.04	0.89	neutral	0.73	neutral	3.22	22.70	deleterious	0.15	0.45	0.49	neutral	0.64	disease	0.51	disease	0.15	neutral	7	1	deleterious	0.4	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.53	medium_impact	0.57	medium_impact	0.68	0.85	NA	NA	0.42	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9158	9158	C	T	MI.1348	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	632	211	A	V	gCc/gTc	7.3	1	0	probably_damaging	1	deleterious	0.04	neutral	2.97	deleterious	-7.68	deleterious	-3.55	high_impact	3.83	0.72	neutral	0.46	neutral	4.55	24.40	deleterious	0.38	0.65	NA	NA	0.9	disease	0.63	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-0.49	medium_impact	2.19	high_impact	0.66	0.9	50.44	9.14	0.51	N	0.75	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4808	4808	C	A	MI.13480	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	339	113	F	L	ttC/ttA	1.64	0.95	0	probably_damaging	1	neutral	0.79	neutral	4.68	neutral	-1.04	deleterious	-4.73	medium_impact	2.04	0.89	neutral	0.73	neutral	3.47	23.00	deleterious	0.15	0.45	0.49	neutral	0.64	disease	0.51	disease	0.15	neutral	7	1	deleterious	0.4	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.53	medium_impact	0.57	medium_impact	0.68	0.85	NA	NA	0.43	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4809	4809	T	G	MI.13481	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	340	114	W	G	Tga/Gga	-4.58	0	0	probably_damaging	1	neutral	0.21	neutral	0.43	deleterious	-11.95	deleterious	-12.57	high_impact	4.15	0.53	damaging	0.04	damaging	3.80	23.40	deleterious	0.02	0.35	0.62	disease	0.83	disease	0.85	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.11	medium_impact	2.35	high_impact	0.06	0.8	NA	NA	0.4	N	0.96	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4809	4809	T	C	MI.13482	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	340	114	W	R	Tga/Cga	-4.58	0	0	probably_damaging	1	neutral	0.25	neutral	0.43	deleterious	-12.85	deleterious	-13.54	high_impact	4.15	0.65	neutral	0.06	damaging	3.48	23.10	deleterious	0.02	0.35	0.82	disease	0.91	disease	0.88	disease	0.68	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	-0.06	medium_impact	2.35	high_impact	0.10	0.8	NA	NA	0.4	N	0.97	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4810	4810	G	C	MI.13483	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	341	114	W	S	tGa/tCa	7.4	1	0	probably_damaging	1	neutral	0.35	neutral	0.43	deleterious	-12.98	deleterious	-13.54	high_impact	3.81	0.45	damaging	0.05	damaging	3.91	23.50	deleterious	0.02	0.35	0.36	neutral	0.91	disease	0.84	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.06	medium_impact	2.06	high_impact	0.06	0.8	NA	NA	0.51	P	0.94	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4810	4810	G	T	MI.13484	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	341	114	W	L	tGa/tTa	7.4	1	0	probably_damaging	1	neutral	0.71	neutral	0.43	deleterious	-11.93	deleterious	-12.57	high_impact	4.15	0.55	damaging	0.04	damaging	4.17	23.80	deleterious	0.03	0.35	0.43	neutral	0.81	disease	0.84	disease	0.7	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.42	medium_impact	2.35	high_impact	0.08	0.8	NA	NA	0.54	P	0.97	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4811	4811	A	T	MI.13485	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	342	114	W	C	tgA/tgT	9.24	1	0	probably_damaging	1	neutral	0.14	neutral	0.43	deleterious	-13.81	deleterious	-12.57	high_impact	4.15	0.56	damaging	0.04	damaging	4.02	23.60	deleterious	0.02	0.35	0.87	disease	0.9	disease	0.86	disease	0.65	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.23	medium_impact	2.35	high_impact	0.09	0.8	NA	NA	0.54	P	0.98	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4811	4811	A	C	MI.13486	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	342	114	W	C	tgA/tgC	9.24	1	0	probably_damaging	1	neutral	0.14	neutral	0.43	deleterious	-13.81	deleterious	-12.57	high_impact	4.15	0.56	damaging	0.04	damaging	3.89	23.50	deleterious	0.02	0.35	0.87	disease	0.9	disease	0.86	disease	0.65	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.23	medium_impact	2.35	high_impact	0.09	0.8	NA	NA	0.53	P	0.98	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4812	4812	G	C	MI.13487	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	343	115	V	L	Gtc/Ctc	3.94	1	0	benign	0.02	neutral	1	neutral	5.25	neutral	2.87	neutral	-2.25	neutral_impact	0.04	0.93	neutral	0.89	neutral	1.88	15.47	deleterious	0.22	0.45	0.59	disease	0.15	neutral	0.29	neutral	0.26	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	1.87	high_impact	-1.11	low_impact	0.42	0.8	1.44	8.33	0.44	N	0.36	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4812	4812	G	T	MI.13488	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	343	115	V	F	Gtc/Ttc	3.94	1	0	possibly_damaging	0.82	neutral	0.78	neutral	4.61	neutral	-0.54	deleterious	-4.37	neutral_impact	0.26	0.84	neutral	0.58	neutral	3.77	23.40	deleterious	0.06	0.35	0.44	neutral	0.28	neutral	0.34	neutral	0.44	neutral	1	0.79	neutral	0.48	deleterious	-3	neutral	0.66	deleterious	-1.4	low_impact	0.51	medium_impact	-0.93	medium_impact	0.42	0.8	1.44	8.33	0.41	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4812	4812	G	A	MI.13489	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	343	115	V	I	Gtc/Atc	3.94	1	0	benign	0.06	neutral	0.46	neutral	4.7	neutral	0.58	neutral	-0.7	medium_impact	2.12	0.92	neutral	0.65	neutral	3.46	23.00	deleterious	0.36	0.5	0.45	neutral	0.32	neutral	0.49	neutral	0.46	neutral	1	0.49	neutral	0.7	deleterious	-3	neutral	0.19	neutral	0.3	medium_impact	0.17	medium_impact	0.64	medium_impact	0.76	0.85	1.44	8.33	0.56	P	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9158	9158	C	A	MI.1349	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	632	211	A	D	gCc/gAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.94	deleterious	-8.91	deleterious	-5.3	high_impact	4.38	0.87	neutral	0.52	neutral	4.78	24.70	deleterious	0.13	0.65	NA	NA	0.95	disease	0.71	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.6	low_impact	-1.4	low_impact	2.66	high_impact	0.58	0.9	50.44	9.14	0.48	N	0.99	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4813	4813	T	G	MI.13490	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	344	115	V	G	gTc/gGc	-0.43	0.62	0	probably_damaging	0.93	neutral	0.35	neutral	4.54	neutral	-2.89	deleterious	-6.57	medium_impact	2.92	0.88	neutral	0.57	neutral	3.76	23.40	deleterious	0.02	0.35	0.87	disease	0.56	disease	0.62	disease	0.67	disease	3	0.93	neutral	0.21	neutral	1	deleterious	0.79	deleterious	-1.83	low_impact	0.06	medium_impact	1.31	medium_impact	0.31	0.8	1.44	8.33	0.38	N	0.90	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4813	4813	T	C	MI.13491	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	344	115	V	A	gTc/gCc	-0.43	0.62	0	possibly_damaging	0.51	neutral	0.51	neutral	4.62	neutral	-0.31	deleterious	-3.67	medium_impact	2.38	0.9	neutral	0.59	neutral	3.51	23.10	deleterious	0.12	0.4	0.69	disease	0.42	neutral	0.62	disease	0.67	disease	3	0.5	neutral	0.5	deleterious	0	NA	0.59	deleterious	-0.81	medium_impact	0.22	medium_impact	0.86	medium_impact	0.16	0.8	1.44	8.33	0.38	N	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4813	4813	T	A	MI.13492	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	344	115	V	D	gTc/gAc	-0.43	0.62	0	probably_damaging	0.95	neutral	0.2	neutral	4.53	deleterious	-3.97	deleterious	-6.53	medium_impact	2.92	0.85	neutral	0.45	neutral	4.58	24.40	deleterious	0.01	0.35	0.93	disease	0.75	disease	0.74	disease	0.7	disease	4	0.97	neutral	0.13	neutral	1	deleterious	0.84	deleterious	-1.97	low_impact	-0.13	medium_impact	1.31	medium_impact	0.14	0.8	1.44	8.33	0.32	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4815	4815	C	A	MI.13493	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	346	116	P	T	Cca/Aca	-14.24	0	0	probably_damaging	1	neutral	0.4	neutral	4.14	deleterious	-7.01	deleterious	-7.73	medium_impact	3.31	0.94	neutral	0.14	damaging	3.56	23.10	deleterious	0.06	0.35	0.7	disease	0.76	disease	0.67	disease	0.37	neutral	3	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.11	medium_impact	1.64	medium_impact	0.51	0.8	NA	NA	0.35	N	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4815	4815	C	G	MI.13494	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	346	116	P	A	Cca/Gca	-14.24	0	0	probably_damaging	1	neutral	0.52	neutral	4.16	deleterious	-5.6	deleterious	-7.73	high_impact	4.12	0.93	neutral	0.15	damaging	2.97	22.10	deleterious	0.08	0.35	0.59	disease	0.65	disease	0.7	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.23	medium_impact	2.32	high_impact	0.67	0.85	NA	NA	0.34	N	0.72	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4815	4815	C	T	MI.13495	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	346	116	P	S	Cca/Tca	-14.24	0	0	probably_damaging	1	neutral	0.42	neutral	4.1	deleterious	-6.26	deleterious	-7.73	high_impact	4.12	0.89	neutral	0.15	damaging	3.82	23.40	deleterious	0.05	0.35	0.75	disease	0.77	disease	0.69	disease	0.66	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.13	medium_impact	2.32	high_impact	0.17	0.8	NA	NA	0.38	N	0.72	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4816	4816	C	T	MI.13496	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	347	116	P	L	cCa/cTa	5.32	1	0	probably_damaging	1	neutral	0.68	neutral	4.22	deleterious	-7.15	deleterious	-9.66	medium_impact	2.8	0.97	neutral	0.12	damaging	4.33	24.00	deleterious	0.03	0.35	0.39	neutral	0.78	disease	0.67	disease	0.66	disease	3	1	deleterious	0.34	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.39	medium_impact	1.21	medium_impact	0.69	0.85	NA	NA	0.45	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4816	4816	C	G	MI.13497	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	347	116	P	R	cCa/cGa	5.32	1	0	probably_damaging	1	neutral	0.35	neutral	4.09	deleterious	-8.46	deleterious	-8.7	high_impact	4.12	0.89	neutral	0.1	damaging	3.52	23.10	deleterious	0.03	0.35	0.84	disease	0.86	disease	0.78	disease	0.67	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.06	medium_impact	2.32	high_impact	0.29	0.8	NA	NA	0.68	P	0.56	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4816	4816	C	A	MI.13498	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	347	116	P	Q	cCa/cAa	5.32	1	0	probably_damaging	1	neutral	0.31	neutral	4.09	deleterious	-8.55	deleterious	-7.73	high_impact	4.12	0.84	neutral	0.12	damaging	4.04	23.70	deleterious	0.06	0.35	0.85	disease	0.82	disease	0.73	disease	0.63	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.02	medium_impact	2.32	high_impact	0.31	0.8	NA	NA	0.62	P	0.83	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4818	4818	G	A	MI.13499	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	349	117	E	K	Gag/Aag	-0.89	0.03	0	probably_damaging	1	neutral	0.84	neutral	4.73	neutral	-0.59	deleterious	-3.86	medium_impact	2.88	0.9	neutral	0.12	damaging	4.40	24.10	deleterious	0.1	0.4	0.82	disease	0.8	disease	0.72	disease	0.66	disease	3	1	deleterious	0.42	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	0.61	medium_impact	1.28	medium_impact	0.62	0.8	NA	NA	0.27	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8590	8590	C	A	MI.135	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	64	22	L	M	Ctg/Atg	-15.14	0	0	possibly_damaging	0.85	neutral	0.12	neutral	4.15	neutral	-2.34	neutral	-1.13	medium_impact	2	0.89	neutral	0.8	neutral	2.35	18.51	deleterious	0.33	0.65	0.77	disease	0.27	neutral	0.36	neutral	0.59	disease	2	0.94	neutral	0.14	neutral	0	NA	0.69	deleterious	-1.47	low_impact	-0.2	medium_impact	0.62	medium_impact	0.60	0.9	25.22	20.33	0.51	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9160	9160	T	A	MI.1350	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	634	212	Y	N	Tac/Aac	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	3.64	deleterious	-6.57	deleterious	-8.03	high_impact	4.53	0.5	damaging	0.07	damaging	4.16	23.80	deleterious	0.25	0.65	NA	NA	0.92	disease	0.69	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.78	high_impact	0.20	0.9	50	8.88	0.4	N	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4818	4818	G	C	MI.13500	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	349	117	E	Q	Gag/Cag	-0.89	0.03	0	probably_damaging	1	neutral	0.56	neutral	4.56	neutral	-1.07	deleterious	-2.9	medium_impact	2.35	0.84	neutral	0.15	damaging	3.31	22.90	deleterious	0.22	0.45	0.84	disease	0.69	disease	0.68	disease	0.64	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.27	medium_impact	0.83	medium_impact	0.57	0.8	NA	NA	0.18	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4819	4819	A	G	MI.13501	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	350	117	E	G	gAg/gGg	7.17	1	0	probably_damaging	1	neutral	0.39	neutral	4.51	neutral	-1.32	deleterious	-6.75	medium_impact	2.47	0.9	neutral	0.19	damaging	4.16	23.80	deleterious	0.06	0.35	0.71	disease	0.68	disease	0.69	disease	0.64	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.1	medium_impact	0.94	medium_impact	0.25	0.8	NA	NA	0.63	P	0.45	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4819	4819	A	C	MI.13502	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	350	117	E	A	gAg/gCg	7.17	1	0	probably_damaging	1	neutral	0.74	neutral	4.58	neutral	-0.42	deleterious	-5.79	medium_impact	2.67	0.88	neutral	0.17	damaging	3.61	23.20	deleterious	0.05	0.35	0.54	disease	0.67	disease	0.66	disease	0.64	disease	3	1	deleterious	0.37	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.46	medium_impact	1.1	medium_impact	0.33	0.8	NA	NA	0.52	N	0.73	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4819	4819	A	T	MI.13503	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	350	117	E	V	gAg/gTg	7.17	1	0	probably_damaging	1	neutral	0.37	neutral	4.51	neutral	-2.36	deleterious	-6.76	medium_impact	3.22	0.85	neutral	0.15	damaging	4.14	23.80	deleterious	0.03	0.35	0.53	disease	0.83	disease	0.7	disease	0.68	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.08	medium_impact	1.57	medium_impact	0.27	0.8	NA	NA	0.55	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4820	4820	G	T	MI.13504	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	351	117	E	D	gaG/gaT	6.94	1	0.07	probably_damaging	1	neutral	0.58	neutral	4.78	neutral	3.12	deleterious	-2.9	medium_impact	2	0.85	neutral	0.24	damaging	3.82	23.40	deleterious	0.29	0.45	0.91	disease	0.42	neutral	0.34	neutral	0.58	disease	2	1	deleterious	0.29	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.29	medium_impact	0.54	medium_impact	0.53	0.8	NA	NA	0.5	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4820	4820	G	C	MI.13505	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	351	117	E	D	gaG/gaC	6.94	1	0.07	probably_damaging	1	neutral	0.58	neutral	4.78	neutral	3.12	deleterious	-2.9	medium_impact	2	0.85	neutral	0.24	damaging	3.65	23.20	deleterious	0.29	0.45	0.91	disease	0.42	neutral	0.34	neutral	0.58	disease	2	1	deleterious	0.29	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.29	medium_impact	0.54	medium_impact	0.53	0.8	NA	NA	0.49	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4821	4821	G	C	MI.13506	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	352	118	V	L	Gtt/Ctt	1.87	1	0	probably_damaging	1	neutral	0.54	neutral	4.31	deleterious	-3.52	deleterious	-2.87	medium_impact	2.6	0.82	neutral	0.18	damaging	3.46	23.00	deleterious	0.06	0.35	0.51	disease	0.6	disease	0.59	disease	0.64	disease	3	0.99	deleterious	0.27	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.25	medium_impact	1.04	medium_impact	0.33	0.8	NA	NA	0.39	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4821	4821	G	A	MI.13507	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	352	118	V	I	Gtt/Att	1.87	1	0	probably_damaging	1	neutral	0.31	neutral	4.3	deleterious	-3.75	neutral	-0.93	low_impact	1.79	0.9	neutral	0.12	damaging	3.58	23.20	deleterious	0.25	0.45	0.61	disease	0.45	neutral	0.46	neutral	0.53	disease	1	1	deleterious	0.16	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	0.02	medium_impact	0.36	medium_impact	0.70	0.85	NA	NA	0.53	N	0.46	polymorphism	1	0.03	rs878983010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4821	4821	G	T	MI.13508	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	352	118	V	F	Gtt/Ttt	1.87	1	0	probably_damaging	1	neutral	0.38	neutral	4.29	deleterious	-4.88	deleterious	-4.8	high_impact	4.02	0.8	neutral	0.09	damaging	3.78	23.40	deleterious	0.02	0.35	0.42	neutral	0.85	disease	0.65	disease	0.7	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.09	medium_impact	2.24	high_impact	0.36	0.8	NA	NA	0.43	N	0.95	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4822	4822	T	A	MI.13509	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	353	118	V	D	gTt/gAt	4.17	1	0	probably_damaging	1	neutral	0.12	neutral	4.29	deleterious	-5.12	deleterious	-6.75	high_impact	4.02	0.88	neutral	0.09	damaging	4.38	24.10	deleterious	0.01	0.35	0.92	disease	0.81	disease	0.74	disease	0.63	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.27	medium_impact	2.24	high_impact	0.12	0.8	NA	NA	0.58	P	0.92	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9160	9160	T	C	MI.1351	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	634	212	Y	H	Tac/Cac	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	3.7	deleterious	-3.96	deleterious	-4.46	high_impact	3.84	0.54	damaging	0.05	damaging	3.70	23.30	deleterious	0.29	0.65	NA	NA	0.9	disease	0.72	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.19	high_impact	0.27	0.9	50	8.88	0.3	N	0.99	disease_causing	1	0.40	.	.	.	.	.	.	COSM6716149	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4822	4822	T	G	MI.13510	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	353	118	V	G	gTt/gGt	4.17	1	0	probably_damaging	1	neutral	0.23	neutral	4.31	deleterious	-3.7	deleterious	-6.76	high_impact	4.02	0.93	neutral	0.13	damaging	3.76	23.40	deleterious	0.01	0.35	0.47	neutral	0.69	disease	0.66	disease	0.66	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	-0.08	medium_impact	2.24	high_impact	0.15	0.8	NA	NA	0.59	P	0.88	polymorphism	1	0.12	rs28571027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4822	4822	T	C	MI.13511	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	353	118	V	A	gTt/gCt	4.17	1	0	probably_damaging	1	neutral	0.36	neutral	4.91	neutral	0.93	deleterious	-3.87	medium_impact	2.92	0.93	neutral	0.15	damaging	3.45	23.00	deleterious	0.05	0.35	0.39	neutral	0.57	disease	0.6	disease	0.64	disease	3	1	deleterious	0.18	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.07	medium_impact	1.31	medium_impact	0.11	0.8	NA	NA	0.56	P	0.52	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4824	4824	A	G	MI.13512	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	355	119	T	A	Acc/Gcc	-14.7	0	0.17	benign	0.36	neutral	0.42	neutral	4.64	neutral	-0.37	deleterious	-4.25	low_impact	0.86	0.98	neutral	0.83	neutral	2.31	18.24	deleterious	0.21	0.45	0.55	disease	0.3	neutral	0.49	neutral	0.58	disease	2	0.51	neutral	0.53	deleterious	-6	neutral	0.44	deleterious	-0.57	medium_impact	0.13	medium_impact	-0.42	medium_impact	0.34	0.8	0.86	7.2	0.4	N	0.84	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4824	4824	A	C	MI.13513	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	355	119	T	P	Acc/Ccc	-14.7	0	0.17	probably_damaging	0.99	neutral	0.23	neutral	4.58	neutral	-2.8	deleterious	-5.49	medium_impact	2.33	0.79	neutral	0.61	neutral	3.40	23.00	deleterious	0.06	0.35	0.75	disease	0.7	disease	0.78	disease	0.71	disease	4	0.99	deleterious	0.12	neutral	1	deleterious	0.79	deleterious	-2.62	low_impact	-0.08	medium_impact	0.82	medium_impact	0.44	0.8	0.86	7.2	0.34	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4824	4824	A	T	MI.13514	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	355	119	T	S	Acc/Tcc	-14.7	0	0.17	possibly_damaging	0.87	neutral	0.46	neutral	4.61	neutral	-1.13	deleterious	-3.53	low_impact	1.04	0.86	neutral	0.55	neutral	3.23	22.80	deleterious	0.32	0.5	0.66	disease	0.34	neutral	0.64	disease	0.66	disease	3	0.86	neutral	0.3	neutral	-3	neutral	0.68	deleterious	-1.55	low_impact	0.17	medium_impact	-0.27	medium_impact	0.64	0.8	0.86	7.2	0.33	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4825	4825	C	T	MI.13515	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	356	119	T	I	aCc/aTc	-0.2	0	0	probably_damaging	0.97	neutral	0.37	neutral	4.68	neutral	-0.78	deleterious	-5.42	low_impact	0.82	0.86	neutral	0.5	neutral	2.83	21.50	deleterious	0.16	0.45	0.45	neutral	0.39	neutral	0.49	neutral	0.45	neutral	1	0.97	neutral	0.2	neutral	-2	neutral	0.68	deleterious	-2.18	low_impact	0.08	medium_impact	-0.45	medium_impact	0.64	0.8	0.86	7.2	0.27	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4825	4825	C	A	MI.13516	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	356	119	T	N	aCc/aAc	-0.2	0	0	probably_damaging	0.98	neutral	0.29	neutral	4.59	neutral	-1.97	deleterious	-4.64	medium_impact	2.33	0.84	neutral	0.52	neutral	3.58	23.20	deleterious	0.28	0.45	0.83	disease	0.56	disease	0.69	disease	0.68	disease	4	0.98	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-2.34	low_impact	-0.01	medium_impact	0.82	medium_impact	0.52	0.8	0.86	7.2	0.33	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4825	4825	C	G	MI.13517	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	356	119	T	S	aCc/aGc	-0.2	0	0	possibly_damaging	0.87	neutral	0.46	neutral	4.61	neutral	-1.13	deleterious	-3.53	low_impact	1.04	0.86	neutral	0.55	neutral	3.46	23.00	deleterious	0.32	0.5	0.66	disease	0.34	neutral	0.64	disease	0.66	disease	3	0.86	neutral	0.3	neutral	-3	neutral	0.68	deleterious	-1.55	low_impact	0.17	medium_impact	-0.27	medium_impact	0.64	0.8	0.86	7.2	0.3	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4827	4827	C	A	MI.13518	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	358	120	Q	K	Caa/Aaa	-15.17	0	0	probably_damaging	0.99	neutral	0.38	neutral	4.6	neutral	-1.32	deleterious	-3.9	medium_impact	2.38	0.88	neutral	0.14	damaging	3.92	23.50	deleterious	0.27	0.45	0.63	disease	0.77	disease	0.61	disease	0.66	disease	3	0.99	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-2.62	low_impact	0.09	medium_impact	0.86	medium_impact	0.33	0.8	NA	NA	0.26	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4827	4827	C	G	MI.13519	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	358	120	Q	E	Caa/Gaa	-15.17	0	0	probably_damaging	0.99	neutral	0.38	neutral	4.84	neutral	0.98	deleterious	-2.93	low_impact	1.44	0.81	neutral	0.13	damaging	3.00	22.20	deleterious	0.27	0.45	0.7	disease	0.68	disease	0.6	disease	0.65	disease	3	0.99	deleterious	0.2	neutral	-2	neutral	0.76	deleterious	-2.62	low_impact	0.09	medium_impact	0.07	medium_impact	0.49	0.8	NA	NA	0.22	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9160	9160	T	G	MI.1352	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	634	212	Y	D	Tac/Gac	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	3.64	deleterious	-7.72	deleterious	-8.92	high_impact	4.53	0.51	damaging	0.06	damaging	4.13	23.80	deleterious	0.15	0.65	NA	NA	0.94	disease	0.76	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.78	high_impact	0.22	0.9	50	8.88	0.41	N	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4828	4828	A	G	MI.13520	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	359	120	Q	R	cAa/cGa	5.32	1	0	probably_damaging	0.99	neutral	0.39	neutral	4.57	neutral	-1.85	deleterious	-3.9	medium_impact	3.1	0.8	neutral	0.13	damaging	3.36	22.90	deleterious	0.23	0.45	0.73	disease	0.8	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.2	neutral	1	deleterious	0.84	deleterious	-2.62	low_impact	0.1	medium_impact	1.47	medium_impact	0.23	0.8	NA	NA	0.57	P	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4828	4828	A	C	MI.13521	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	359	120	Q	P	cAa/cCa	5.32	1	0	probably_damaging	1	neutral	0.23	neutral	4.53	neutral	-2.04	deleterious	-5.86	medium_impact	3.21	0.87	neutral	0.14	damaging	3.24	22.80	deleterious	0.04	0.35	0.85	disease	0.8	disease	0.52	disease	0.61	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.08	medium_impact	1.56	medium_impact	0.19	0.8	NA	NA	0.57	P	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4828	4828	A	T	MI.13522	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	359	120	Q	L	cAa/cTa	5.32	1	0	probably_damaging	1	neutral	0.74	neutral	4.56	deleterious	-3.03	deleterious	-6.83	medium_impact	3.21	0.81	neutral	0.12	damaging	3.76	23.30	deleterious	0.09	0.35	0.83	disease	0.81	disease	0.58	disease	0.63	disease	3	1	deleterious	0.37	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.46	medium_impact	1.56	medium_impact	0.15	0.8	NA	NA	0.43	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4829	4829	A	C	MI.13523	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	360	120	Q	H	caA/caC	6.71	1	0	probably_damaging	1	neutral	0.55	neutral	4.54	neutral	-2.24	deleterious	-4.88	medium_impact	3.21	0.81	neutral	0.12	damaging	3.35	22.90	deleterious	0.22	0.45	0.78	disease	0.76	disease	0.64	disease	0.65	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.26	medium_impact	1.56	medium_impact	0.28	0.8	NA	NA	0.53	P	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4829	4829	A	T	MI.13524	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	360	120	Q	H	caA/caT	6.71	1	0	probably_damaging	1	neutral	0.55	neutral	4.54	neutral	-2.24	deleterious	-4.88	medium_impact	3.21	0.81	neutral	0.12	damaging	3.48	23.10	deleterious	0.22	0.45	0.78	disease	0.76	disease	0.64	disease	0.65	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.26	medium_impact	1.56	medium_impact	0.28	0.8	NA	NA	0.53	P	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4830	4830	G	T	MI.13525	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	361	121	G	C	Ggc/Tgc	2.1	1	0	probably_damaging	1	neutral	0.15	neutral	4.32	deleterious	-7.08	deleterious	-8.78	medium_impact	3.5	0.71	neutral	0.2	damaging	4.06	23.70	deleterious	0.07	0.35	0.83	disease	0.88	disease	0.6	disease	0.63	disease	3	1	deleterious	0.08	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	-0.21	medium_impact	1.8	medium_impact	0.08	0.8	0.29	7.8	0.49	N	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4830	4830	G	C	MI.13526	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	361	121	G	R	Ggc/Cgc	2.1	1	0	probably_damaging	1	neutral	0.61	neutral	4.38	deleterious	-3.69	deleterious	-7.8	high_impact	4.05	0.88	neutral	0.27	damaging	3.90	23.50	deleterious	0.07	0.35	0.92	disease	0.87	disease	0.67	disease	0.6	disease	2	1	deleterious	0.31	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	0.32	medium_impact	2.27	high_impact	0.50	0.8	0.29	7.8	0.49	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4830	4830	G	A	MI.13527	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	361	121	G	S	Ggc/Agc	2.1	1	0	probably_damaging	1	neutral	0.86	neutral	4.44	neutral	-2.91	deleterious	-5.85	medium_impact	2.19	0.79	neutral	0.38	neutral	4.16	23.80	deleterious	0.13	0.4	0.8	disease	0.81	disease	0.49	neutral	0.61	disease	2	1	deleterious	0.43	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.65	medium_impact	0.7	medium_impact	0.35	0.8	0.29	7.8	0.36	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4831	4831	G	A	MI.13528	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	362	121	G	D	gGc/gAc	6.01	1	0.01	probably_damaging	1	neutral	0.64	neutral	4.38	deleterious	-3.71	deleterious	-6.83	high_impact	3.7	0.7	neutral	0.24	damaging	3.80	23.40	deleterious	0.08	0.35	0.68	disease	0.87	disease	0.64	disease	0.68	disease	4	1	deleterious	0.32	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.35	medium_impact	1.97	medium_impact	0.08	0.8	0.29	7.8	0.57	P	0.95	polymorphism	1	0.10	.	.	.	.	.	pituitary oncocytoma	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4831	4831	G	T	MI.13529	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	362	121	G	V	gGc/gTc	6.01	1	0.01	probably_damaging	1	neutral	0.5	neutral	4.35	deleterious	-4.12	deleterious	-8.78	medium_impact	3.5	0.64	neutral	0.28	damaging	3.71	23.30	deleterious	0.06	0.35	0.68	disease	0.86	disease	0.61	disease	0.68	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.21	medium_impact	1.8	medium_impact	0.08	0.8	0.29	7.8	0.57	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9161	9161	A	T	MI.1353	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	635	212	Y	F	tAc/tTc	5.68	1	0	probably_damaging	0.99	neutral	0.09	neutral	4.26	neutral	-0.36	deleterious	-3.57	medium_impact	2.85	0.54	damaging	0.07	damaging	3.59	23.20	deleterious	0.24	0.65	NA	NA	0.91	disease	0.61	disease	0.67	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.91	deleterious	-2.65	low_impact	-0.28	medium_impact	1.35	medium_impact	0.35	0.9	50	8.88	0.47	N	0.81	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4831	4831	G	C	MI.13530	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	362	121	G	A	gGc/gCc	6.01	1	0.01	probably_damaging	1	neutral	0.88	neutral	4.46	neutral	-2.05	deleterious	-5.85	medium_impact	2.95	0.72	neutral	0.37	neutral	3.05	22.40	deleterious	0.14	0.4	0.64	disease	0.72	disease	0.48	neutral	0.5	neutral	0	1	deleterious	0.44	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.69	medium_impact	1.34	medium_impact	0.20	0.8	0.29	7.8	0.49	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4833	4833	A	G	MI.13531	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	364	122	T	A	Acc/Gcc	-9.64	0	0.16	benign	0.33	neutral	0.51	neutral	4.86	neutral	1.3	neutral	-0.96	low_impact	0.88	0.93	neutral	0.81	neutral	1.69	14.33	neutral	0.3	0.45	0.51	disease	0.21	neutral	0.47	neutral	0.28	neutral	4	0.4	neutral	0.59	deleterious	-6	neutral	0.45	deleterious	-0.52	medium_impact	0.22	medium_impact	-0.4	medium_impact	0.28	0.8	3.46	8.46	0.35	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	CPD	0.15	A4833G	Diabetes helper mutation, AD, PD	+	-	Reported, haplogroup G marker	2	.	P	P	neutral
chrM	4833	4833	A	C	MI.13532	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	364	122	T	P	Acc/Ccc	-9.64	0	0.16	probably_damaging	0.92	neutral	0.24	neutral	4.82	neutral	-1.08	deleterious	-2.77	medium_impact	1.98	0.75	neutral	0.39	neutral	3.38	23.00	deleterious	0.08	0.35	0.89	disease	0.67	disease	0.5	neutral	0.59	disease	2	0.94	neutral	0.16	neutral	1	deleterious	0.80	deleterious	-1.77	low_impact	-0.07	medium_impact	0.52	medium_impact	0.41	0.8	3.46	8.46	0.31	N	0.82	polymorphism	1	0.05	rs386419995	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4833	4833	A	T	MI.13533	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	364	122	T	S	Acc/Tcc	-9.64	0	0.16	possibly_damaging	0.61	neutral	0.58	neutral	4.73	neutral	-0.64	neutral	-1.65	neutral_impact	-0.1	0.78	neutral	0.96	neutral	0.49	7.36	deleterious	0.42	0.55	0.58	disease	0.06	neutral	0.21	neutral	0.38	neutral	2	0.55	neutral	0.49	deleterious	-3	neutral	0.57	deleterious	-0.98	medium_impact	0.29	medium_impact	-1.23	low_impact	0.62	0.8	3.46	8.46	0.38	N	0.44	polymorphism	1	0.02	rs386419995	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4834	4834	C	A	MI.13534	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	365	122	T	N	aCc/aAc	0.03	0	0	probably_damaging	0.92	neutral	0.36	neutral	4.61	neutral	-2.7	deleterious	-2.77	medium_impact	2.32	0.81	neutral	0.58	neutral	3.51	23.10	deleterious	0.3	0.45	0.87	disease	0.43	neutral	0.55	disease	0.66	disease	3	0.93	neutral	0.22	neutral	1	deleterious	0.73	deleterious	-1.77	low_impact	0.07	medium_impact	0.81	medium_impact	0.52	0.8	3.46	8.46	0.34	N	0.70	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4834	4834	C	G	MI.13535	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	365	122	T	S	aCc/aGc	0.03	0	0	possibly_damaging	0.61	neutral	0.58	neutral	4.73	neutral	-0.64	neutral	-1.65	neutral_impact	-0.1	0.78	neutral	0.96	neutral	0.67	8.61	deleterious	0.42	0.55	0.58	disease	0.06	neutral	0.21	neutral	0.38	neutral	2	0.55	neutral	0.49	deleterious	-3	neutral	0.57	deleterious	-0.98	medium_impact	0.29	medium_impact	-1.23	low_impact	0.62	0.8	3.46	8.46	0.38	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4834	4834	C	T	MI.13536	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	365	122	T	I	aCc/aTc	0.03	0	0	benign	0.04	neutral	0.5	neutral	4.68	neutral	-2.1	neutral	1.58	neutral_impact	-0.6	0.91	neutral	0.96	neutral	-0.61	0.12	neutral	0.16	0.45	0.44	neutral	0.14	neutral	0.2	neutral	0.26	neutral	5	0.46	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.47	medium_impact	0.21	medium_impact	-1.65	low_impact	0.38	0.8	3.46	8.46	0.33	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4836	4836	C	G	MI.13537	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	367	123	P	A	Cct/Gct	-9.41	0	0	benign	0.04	neutral	0.78	neutral	4.43	deleterious	-3.91	deleterious	-4.26	medium_impact	2.29	0.9	neutral	0.66	neutral	1.17	11.58	neutral	0.31	0.45	0.45	neutral	0.21	neutral	0.52	disease	0.43	neutral	1	0.15	neutral	0.87	deleterious	-3	neutral	0.16	neutral	0.47	medium_impact	0.51	medium_impact	0.78	medium_impact	0.66	0.8	8.65	7.87	0.34	N	0.50	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4836	4836	C	T	MI.13538	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	367	123	P	S	Cct/Tct	-9.41	0	0	benign	0.06	neutral	0.76	neutral	4.51	deleterious	-4.01	deleterious	-3.4	neutral_impact	0.38	0.89	neutral	0.99	neutral	0.44	6.98	deleterious	0.48	0.55	0.57	disease	0.11	neutral	0.32	neutral	0.3	neutral	4	0.15	neutral	0.85	deleterious	-6	neutral	0.19	neutral	0.3	medium_impact	0.49	medium_impact	-0.83	medium_impact	0.12	0.8	8.65	7.87	0.35	N	0.50	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4836	4836	C	A	MI.13539	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	367	123	P	T	Cct/Act	-9.41	0	0	benign	0.04	neutral	0.61	neutral	4.6	deleterious	-3.12	deleterious	-3.89	neutral_impact	0.55	0.92	neutral	0.97	neutral	0.49	7.36	deleterious	0.31	0.45	0.42	neutral	0.12	neutral	0.33	neutral	0.25	neutral	5	0.34	neutral	0.79	deleterious	-6	neutral	0.14	neutral	0.47	medium_impact	0.32	medium_impact	-0.68	medium_impact	0.50	0.8	8.65	7.87	0.43	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9161	9161	A	C	MI.1354	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	635	212	Y	S	tAc/tCc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	3.65	deleterious	-6.29	deleterious	-8.01	high_impact	4.18	0.49	damaging	0.09	damaging	3.88	23.50	deleterious	0.2	0.65	NA	NA	0.93	disease	0.68	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.48	high_impact	0.26	0.9	50	8.88	0.42	N	0.99	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4837	4837	C	G	MI.13540	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	368	123	P	R	cCt/cGt	-7.34	0	0	possibly_damaging	0.86	neutral	0.54	neutral	4.4	deleterious	-5.2	deleterious	-5.27	medium_impact	3.1	0.87	neutral	0.35	neutral	3.15	22.60	deleterious	0.1	0.4	0.54	disease	0.48	neutral	0.62	disease	0.63	disease	3	0.84	neutral	0.34	neutral	0	NA	0.69	deleterious	-1.52	low_impact	0.25	medium_impact	1.47	medium_impact	0.37	0.8	8.65	7.87	0.3	N	0.86	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4837	4837	C	A	MI.13541	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	368	123	P	H	cCt/cAt	-7.34	0	0	probably_damaging	0.95	neutral	0.17	neutral	4.4	deleterious	-6.14	deleterious	-5.03	medium_impact	1.95	0.89	neutral	0.81	neutral	2.70	20.80	deleterious	0.16	0.45	0.7	disease	0.39	neutral	0.51	disease	0.65	disease	3	0.97	neutral	0.11	neutral	1	deleterious	0.70	deleterious	-1.97	low_impact	-0.17	medium_impact	0.5	medium_impact	0.27	0.8	8.65	7.87	0.48	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4837	4837	C	T	MI.13542	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	368	123	P	L	cCt/cTt	-7.34	0	0	possibly_damaging	0.58	neutral	0.38	neutral	4.4	deleterious	-5.13	deleterious	-6.24	medium_impact	2.4	0.92	neutral	0.55	neutral	2.43	18.99	deleterious	0.17	0.45	0.49	neutral	0.37	neutral	0.52	disease	0.45	neutral	1	0.64	neutral	0.4	neutral	0	NA	0.54	deleterious	-0.93	medium_impact	0.09	medium_impact	0.88	medium_impact	0.59	0.8	8.65	7.87	0.43	N	0.93	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4839	4839	C	G	MI.13543	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	370	124	L	V	Ctg/Gtg	-9.41	0	0	probably_damaging	1	neutral	0.24	neutral	4.61	neutral	-0.32	deleterious	-2.89	high_impact	3.63	0.87	neutral	0.14	damaging	3.39	23.00	deleterious	0.39	0.5	0.6	disease	0.39	neutral	0.67	disease	0.61	disease	2	1	deleterious	0.12	neutral	2	deleterious	0.74	deleterious	-3.54	low_impact	-0.07	medium_impact	1.91	medium_impact	0.45	0.8	0.58	7.76	0.38	N	0.77	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4839	4839	C	A	MI.13544	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	370	124	L	M	Ctg/Atg	-9.41	0	0	probably_damaging	1	neutral	0.25	neutral	4.52	neutral	-2.02	neutral	-1.85	low_impact	1.21	0.9	neutral	0.83	neutral	3.66	23.20	deleterious	0.34	0.5	0.79	disease	0.17	neutral	0.42	neutral	0.33	neutral	3	1	deleterious	0.13	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	-0.06	medium_impact	-0.13	medium_impact	0.54	0.8	0.58	7.76	0.5	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4840	4840	T	A	MI.13545	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	371	124	L	Q	cTg/cAg	-0.89	0	0	probably_damaging	1	neutral	0.17	neutral	4.5	neutral	-2.93	deleterious	-5.78	high_impact	3.63	0.89	neutral	0.12	damaging	3.95	23.60	deleterious	0.04	0.35	0.94	disease	0.68	disease	0.66	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.17	medium_impact	1.91	medium_impact	0.14	0.8	0.58	7.76	0.38	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4840	4840	T	G	MI.13546	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	371	124	L	R	cTg/cGg	-0.89	0	0	probably_damaging	1	neutral	0.11	neutral	4.5	neutral	-2.8	deleterious	-5.8	medium_impact	3.29	0.85	neutral	0.11	damaging	4.09	23.70	deleterious	0.03	0.35	0.93	disease	0.75	disease	0.77	disease	0.7	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	-0.3	medium_impact	1.63	medium_impact	0.17	0.8	0.58	7.76	0.32	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4840	4840	T	C	MI.13547	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	371	124	L	P	cTg/cCg	-0.89	0	0	probably_damaging	1	neutral	0.12	neutral	4.77	neutral	0.88	deleterious	-6.78	medium_impact	3.08	0.88	neutral	0.12	damaging	3.83	23.40	deleterious	0.03	0.35	0.93	disease	0.71	disease	0.78	disease	0.74	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.27	medium_impact	1.45	medium_impact	0.14	0.8	0.58	7.76	0.38	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4842	4842	A	G	MI.13548	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	373	125	T	A	Aca/Gca	-3.42	0	0	benign	0.04	neutral	0.57	neutral	4.67	neutral	0.37	neutral	-1.28	low_impact	1.48	0.89	neutral	0.81	neutral	-0.33	0.56	neutral	0.29	0.45	0.37	neutral	0.22	neutral	0.46	neutral	0.41	neutral	2	0.38	neutral	0.77	deleterious	-6	neutral	0.14	neutral	0.47	medium_impact	0.28	medium_impact	0.1	medium_impact	0.43	0.8	15.85	9.38	0.27	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4842	4842	A	C	MI.13549	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	373	125	T	P	Aca/Cca	-3.42	0	0	possibly_damaging	0.45	neutral	0.24	neutral	4.62	neutral	0.77	neutral	-2.09	low_impact	0.91	0.92	neutral	0.8	neutral	1.62	13.98	neutral	0.09	0.35	0.38	neutral	0.56	disease	0.53	disease	0.23	neutral	5	0.73	neutral	0.4	neutral	-3	neutral	0.53	deleterious	-0.72	medium_impact	-0.07	medium_impact	-0.38	medium_impact	0.42	0.8	15.85	9.38	0.41	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9161	9161	A	G	MI.1355	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	635	212	Y	C	tAc/tGc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	3.64	deleterious	-7.79	deleterious	-8.05	high_impact	4.53	0.46	damaging	0.05	damaging	3.70	23.30	deleterious	0.26	0.65	NA	NA	0.92	disease	0.73	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.78	high_impact	0.24	0.9	50	8.88	0.45	N	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4842	4842	A	T	MI.13550	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	373	125	T	S	Aca/Tca	-3.42	0	0	benign	0.1	neutral	0.46	neutral	4.68	neutral	0.71	neutral	-0.35	neutral_impact	0.1	0.83	neutral	0.98	neutral	-1.06	0.01	neutral	0.31	0.45	0.4	neutral	0.12	neutral	0.33	neutral	0.28	neutral	4	0.47	neutral	0.68	deleterious	-6	neutral	0.20	neutral	0.08	medium_impact	0.17	medium_impact	-1.06	low_impact	0.64	0.8	15.85	9.38	0.38	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4843	4843	C	T	MI.13551	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	374	125	T	M	aCa/aTa	-1.12	0	0	benign	0.01	neutral	0.28	neutral	4.58	neutral	-1.65	neutral	-0.86	neutral_impact	0.66	0.92	neutral	0.98	neutral	0.48	7.28	deleterious	0.17	0.45	0.48	neutral	0.15	neutral	0.35	neutral	0.25	neutral	5	0.72	neutral	0.64	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	-0.02	medium_impact	-0.59	medium_impact	0.54	0.8	15.85	9.38	0.46	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4843	4843	C	A	MI.13552	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	374	125	T	K	aCa/aAa	-1.12	0	0	benign	0.15	neutral	0.33	neutral	4.67	neutral	-2.47	neutral	-1.33	neutral_impact	0.3	0.84	neutral	0.91	neutral	0.86	9.83	deleterious	0.11	0.4	0.79	disease	0.37	neutral	0.48	neutral	0.64	disease	3	0.61	neutral	0.59	deleterious	-6	neutral	0.30	neutral	-0.11	medium_impact	0.04	medium_impact	-0.89	medium_impact	0.33	0.8	15.85	9.38	0.39	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4845	4845	T	C	MI.13553	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	376	126	S	P	Tcc/Ccc	-7.57	0	0	benign	0.02	neutral	0.23	neutral	4.39	deleterious	-4.67	deleterious	-3.04	low_impact	1.26	0.98	neutral	0.83	neutral	2.74	21.00	deleterious	0.06	0.35	0.96	disease	0.8	disease	0.58	disease	0.7	disease	4	0.76	neutral	0.61	deleterious	-6	neutral	0.37	neutral	0.75	medium_impact	-0.08	medium_impact	-0.08	medium_impact	0.37	0.8	2.02	7.51	0.36	N	0.36	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4845	4845	T	A	MI.13554	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	376	126	S	T	Tcc/Acc	-7.57	0	0	possibly_damaging	0.58	neutral	0.48	neutral	4.47	neutral	-1.9	neutral	-2.22	neutral_impact	0.1	0.88	neutral	0.93	neutral	2.07	16.69	deleterious	0.27	0.45	0.72	disease	0.04	neutral	0.28	neutral	0.33	neutral	3	0.58	neutral	0.45	neutral	-3	neutral	0.59	deleterious	-0.93	medium_impact	0.19	medium_impact	-1.06	low_impact	0.63	0.8	2.02	7.51	0.4	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4845	4845	T	G	MI.13555	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	376	126	S	A	Tcc/Gcc	-7.57	0	0	benign	0.42	neutral	0.51	neutral	4.46	neutral	0.08	neutral	-2.17	low_impact	1.46	0.92	neutral	0.88	neutral	2.59	20.10	deleterious	0.31	0.45	0.78	disease	0.33	neutral	0.58	disease	0.66	disease	3	0.44	neutral	0.55	deleterious	-6	neutral	0.60	deleterious	-0.67	medium_impact	0.22	medium_impact	0.09	medium_impact	0.51	0.8	2.02	7.51	0.38	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4846	4846	C	G	MI.13556	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	377	126	S	C	tCc/tGc	0.26	0	0	probably_damaging	0.96	neutral	0.18	neutral	4.38	deleterious	-4.52	deleterious	-4.18	medium_impact	2.29	0.82	neutral	0.4	neutral	3.49	23.10	deleterious	0.07	0.35	0.96	disease	0.65	disease	0.61	disease	0.78	disease	6	0.98	neutral	0.11	neutral	1	deleterious	0.82	deleterious	-2.06	low_impact	-0.16	medium_impact	0.78	medium_impact	0.34	0.8	2.02	7.51	0.32	N	0.51	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4846	4846	C	A	MI.13557	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	377	126	S	Y	tCc/tAc	0.26	0	0	probably_damaging	0.95	neutral	1	neutral	4.39	deleterious	-3.93	deleterious	-4.98	medium_impact	2.63	0.88	neutral	0.47	neutral	4.07	23.70	deleterious	0.05	0.35	0.93	disease	0.65	disease	0.66	disease	0.74	disease	5	0.95	neutral	0.53	deleterious	1	deleterious	0.84	deleterious	-1.97	low_impact	1.87	high_impact	1.07	medium_impact	0.39	0.8	2.02	7.51	0.27	N	0.91	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4846	4846	C	T	MI.13558	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	377	126	S	F	tCc/tTc	0.26	0	0	probably_damaging	0.95	neutral	0.73	neutral	4.42	deleterious	-3.21	deleterious	-5.15	medium_impact	2.98	0.86	neutral	0.46	neutral	4.11	23.70	deleterious	0.05	0.35	0.81	disease	0.67	disease	0.65	disease	0.69	disease	4	0.94	neutral	0.39	neutral	1	deleterious	0.82	deleterious	-1.97	low_impact	0.45	medium_impact	1.36	medium_impact	0.22	0.8	2.02	7.51	0.22	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4848	4848	G	C	MI.13559	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	379	127	G	R	Ggc/Cgc	-2.5	0	0	probably_damaging	0.97	neutral	0.35	neutral	4.55	deleterious	-3.71	deleterious	-7.03	high_impact	3.52	0.87	neutral	0.24	damaging	3.92	23.50	deleterious	0.03	0.35	0.8	disease	0.84	disease	0.75	disease	0.69	disease	4	0.97	neutral	0.19	neutral	2	deleterious	0.86	deleterious	-2.18	low_impact	0.06	medium_impact	1.82	medium_impact	0.62	0.8	NA	NA	0.37	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9163	9163	G	C	MI.1356	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	637	213	V	L	Gtt/Ctt	-3.57	0	0	probably_damaging	0.98	neutral	0.08	neutral	3.16	deleterious	-4.34	deleterious	-2.63	high_impact	3.94	0.65	neutral	0.58	neutral	3.66	23.20	deleterious	0.18	0.65	NA	NA	0.89	disease	0.7	disease	0.74	disease	5	0.99	deleterious	0.05	neutral	2	deleterious	0.85	deleterious	-2.36	low_impact	-0.31	medium_impact	2.28	high_impact	0.39	0.9	48.23	8.71	0.42	N	0.70	disease_causing	0.97	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4848	4848	G	T	MI.13560	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	379	127	G	C	Ggc/Tgc	-2.5	0	0	probably_damaging	0.99	neutral	0.18	neutral	4.56	deleterious	-3.97	deleterious	-7.82	low_impact	1.23	0.83	neutral	0.47	neutral	4.10	23.70	deleterious	0.06	0.35	0.84	disease	0.76	disease	0.46	neutral	0.38	neutral	2	0.99	deleterious	0.1	neutral	-2	neutral	0.81	deleterious	-2.62	low_impact	-0.16	medium_impact	-0.11	medium_impact	0.38	0.8	NA	NA	0.35	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4848	4848	G	A	MI.13561	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	379	127	G	S	Ggc/Agc	-2.5	0	0	possibly_damaging	0.77	neutral	0.4	neutral	4.9	neutral	-0.59	deleterious	-4.99	low_impact	1.74	0.9	neutral	0.7	neutral	4.08	23.70	deleterious	0.11	0.4	0.7	disease	0.61	disease	0.45	neutral	0.22	neutral	6	0.78	neutral	0.32	neutral	-3	neutral	0.73	deleterious	-1.28	low_impact	0.11	medium_impact	0.32	medium_impact	0.66	0.8	NA	NA	0.46	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4849	4849	G	A	MI.13562	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	380	127	G	D	gGc/gAc	4.17	1	0	probably_damaging	0.95	neutral	0.2	neutral	4.55	deleterious	-4.53	deleterious	-6.21	high_impact	3.52	0.83	neutral	0.28	damaging	3.77	23.40	deleterious	0.02	0.35	0.89	disease	0.83	disease	0.74	disease	0.64	disease	3	0.97	neutral	0.13	neutral	2	deleterious	0.83	deleterious	-1.97	low_impact	-0.13	medium_impact	1.82	medium_impact	0.26	0.8	NA	NA	0.55	P	0.95	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4849	4849	G	T	MI.13563	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	380	127	G	V	gGc/gTc	4.17	1	0	possibly_damaging	0.85	neutral	0.5	neutral	4.61	neutral	-0.98	deleterious	-7.83	medium_impact	2.14	0.86	neutral	0.34	neutral	3.75	23.30	deleterious	0.07	0.35	0.38	neutral	0.74	disease	0.63	disease	0.65	disease	3	0.84	neutral	0.33	neutral	0	NA	0.72	deleterious	-1.49	low_impact	0.21	medium_impact	0.66	medium_impact	0.21	0.8	NA	NA	0.44	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4849	4849	G	C	MI.13564	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	380	127	G	A	gGc/gCc	4.17	1	0	benign	0.15	neutral	0.51	neutral	4.84	neutral	0.13	deleterious	-4.87	low_impact	0.82	0.9	neutral	0.63	neutral	1.96	15.99	deleterious	0.14	0.4	0.44	neutral	0.2	neutral	0.42	neutral	0.36	neutral	3	0.4	neutral	0.68	deleterious	-6	neutral	0.33	neutral	-0.11	medium_impact	0.22	medium_impact	-0.45	medium_impact	0.52	0.8	NA	NA	0.59	P	0.74	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4851	4851	C	G	MI.13565	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	382	128	L	V	Ctg/Gtg	-5.5	0	0	possibly_damaging	0.67	neutral	0.09	neutral	4.33	neutral	-1.54	neutral	-2.05	medium_impact	2.8	0.95	neutral	0.27	damaging	3.37	22.90	deleterious	0.22	0.45	0.78	disease	0.35	neutral	0.51	disease	0.63	disease	3	0.92	neutral	0.21	neutral	0	NA	0.69	deleterious	-1.08	low_impact	-0.35	medium_impact	1.21	medium_impact	0.62	0.8	NA	NA	0.48	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4851	4851	C	A	MI.13566	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	382	128	L	M	Ctg/Atg	-5.5	0	0	benign	0.34	neutral	0.17	neutral	4.37	deleterious	-3.14	neutral	-0.02	neutral_impact	0.78	0.9	neutral	0.84	neutral	1.42	12.89	neutral	0.19	0.45	0.85	disease	0.11	neutral	0.32	neutral	0.42	neutral	2	0.8	neutral	0.42	neutral	-6	neutral	0.53	deleterious	-0.53	medium_impact	-0.17	medium_impact	-0.49	medium_impact	0.42	0.8	NA	NA	0.54	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4852	4852	T	A	MI.13567	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	383	128	L	Q	cTg/cAg	-4.11	0	0	probably_damaging	0.97	neutral	0.14	neutral	4.21	deleterious	-5.36	deleterious	-4.19	high_impact	3.69	0.89	neutral	0.13	damaging	4.15	23.80	deleterious	0.03	0.35	0.92	disease	0.71	disease	0.6	disease	0.65	disease	3	0.99	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-2.18	low_impact	-0.23	medium_impact	1.96	medium_impact	0.36	0.8	NA	NA	0.49	N	0.94	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	T4852A	LHON	+	-	Reported	1	.	P	P	damaging
chrM	4852	4852	T	C	MI.13568	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	383	128	L	P	cTg/cCg	-4.11	0	0	probably_damaging	0.98	neutral	0.17	neutral	4.21	deleterious	-5.75	deleterious	-5.51	high_impact	3.69	0.88	neutral	0.1	damaging	3.87	23.50	deleterious	0.02	0.35	0.95	disease	0.77	disease	0.71	disease	0.7	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-2.34	low_impact	-0.17	medium_impact	1.96	medium_impact	0.31	0.8	NA	NA	0.36	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4852	4852	T	G	MI.13569	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	383	128	L	R	cTg/cGg	-4.11	0	0	probably_damaging	0.97	neutral	0.05	neutral	4.22	deleterious	-5.18	deleterious	-4.57	high_impact	3.69	0.85	neutral	0.1	damaging	4.16	23.80	deleterious	0.02	0.35	0.95	disease	0.78	disease	0.72	disease	0.7	disease	4	0.99	deleterious	0.04	neutral	2	deleterious	0.87	deleterious	-2.18	low_impact	-0.5	medium_impact	1.96	medium_impact	0.24	0.8	NA	NA	0.38	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9163	9163	G	A	MI.1357	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	637	213	V	I	Gtt/Att	-3.57	0	0	probably_damaging	0.98	neutral	0.27	neutral	3.77	neutral	-1.01	neutral	-0.86	medium_impact	2.33	0.84	neutral	0.68	neutral	3.78	23.40	deleterious	0.27	0.65	NA	NA	0.72	disease	0.64	disease	0.53	disease	1	0.98	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-2.36	low_impact	0.05	medium_impact	0.9	medium_impact	0.58	0.9	48.23	8.71	0.3	N	0.41	disease_causing	0.92	0.06	rs2298010	.	.	.	.	.	COSM1138421	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4854	4854	C	G	MI.13570	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	385	129	L	V	Ctt/Gtt	-2.27	0	0	possibly_damaging	0.71	neutral	0.3	neutral	4.36	neutral	-1.54	neutral	-0.01	neutral_impact	0.65	0.94	neutral	0.87	neutral	2.25	17.81	deleterious	0.18	0.45	0.9	disease	0.3	neutral	0.33	neutral	0.64	disease	3	0.78	neutral	0.3	neutral	-3	neutral	0.73	deleterious	-1.15	low_impact	0	medium_impact	-0.6	medium_impact	0.49	0.8	NA	NA	0.5	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4854	4854	C	T	MI.13571	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	385	129	L	F	Ctt/Ttt	-2.27	0	0	probably_damaging	0.98	neutral	0.24	neutral	4.35	neutral	-1.67	deleterious	-2.53	low_impact	1.32	0.91	neutral	0.41	neutral	3.92	23.50	deleterious	0.15	0.4	0.95	disease	0.51	disease	0.55	disease	0.75	disease	5	0.99	deleterious	0.13	neutral	-2	neutral	0.81	deleterious	-2.34	low_impact	-0.07	medium_impact	-0.03	medium_impact	0.29	0.8	NA	NA	0.43	N	0.38	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4854	4854	C	A	MI.13572	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	385	129	L	I	Ctt/Att	-2.27	0	0	benign	0.26	neutral	1	neutral	4.63	neutral	-0.04	neutral	0.77	neutral_impact	-1.27	0.91	neutral	0.9	neutral	1.38	12.70	neutral	0.18	0.45	0.68	disease	0.02	neutral	0.18	neutral	0.39	neutral	2	0.26	neutral	0.87	deleterious	-6	neutral	0.46	deleterious	-0.38	medium_impact	1.87	high_impact	-2.21	low_impact	0.36	0.8	NA	NA	0.39	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4855	4855	T	C	MI.13573	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	386	129	L	P	cTt/cCt	0.72	0.19	0	probably_damaging	0.99	neutral	0.14	neutral	4.2	deleterious	-5.72	deleterious	-5.25	medium_impact	2.6	0.76	neutral	0.2	damaging	3.82	23.40	deleterious	0.03	0.35	0.99	disease	0.84	disease	0.7	disease	0.7	disease	4	1	deleterious	0.08	neutral	1	deleterious	0.89	deleterious	-2.62	low_impact	-0.23	medium_impact	1.04	medium_impact	0.28	0.8	NA	NA	0.31	N	0.88	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4855	4855	T	A	MI.13574	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	386	129	L	H	cTt/cAt	0.72	0.19	0	probably_damaging	0.99	neutral	0.07	neutral	4.2	deleterious	-5.77	deleterious	-5.34	medium_impact	2.6	0.8	neutral	0.24	damaging	4.06	23.70	deleterious	0.04	0.35	1	disease	0.66	disease	0.65	disease	0.8	disease	6	1	deleterious	0.04	neutral	1	deleterious	0.84	deleterious	-2.62	low_impact	-0.42	medium_impact	1.04	medium_impact	0.28	0.8	NA	NA	0.29	N	0.79	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4855	4855	T	G	MI.13575	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	386	129	L	R	cTt/cGt	0.72	0.19	0	probably_damaging	0.99	deleterious	0.04	neutral	4.2	deleterious	-5.21	deleterious	-5.04	medium_impact	2.6	0.76	neutral	0.21	damaging	4.15	23.80	deleterious	0.02	0.35	0.99	disease	0.82	disease	0.7	disease	0.7	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.90	deleterious	-2.62	low_impact	-0.56	medium_impact	1.04	medium_impact	0.20	0.8	NA	NA	0.3	N	0.90	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4857	4857	C	G	MI.13576	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	388	130	L	V	Ctt/Gtt	-5.27	0	0	benign	0.15	neutral	0.17	neutral	4.32	neutral	-1.95	deleterious	-2.52	medium_impact	2.7	0.95	neutral	0.44	neutral	3.37	22.90	deleterious	0.11	0.4	0.38	neutral	0.39	neutral	0.55	disease	0.45	neutral	1	0.8	neutral	0.51	deleterious	-3	neutral	0.32	neutral	-0.11	medium_impact	-0.17	medium_impact	1.13	medium_impact	0.56	0.8	NA	NA	0.44	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4857	4857	C	T	MI.13577	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	388	130	L	F	Ctt/Ttt	-5.27	0	0	probably_damaging	0.95	neutral	0.2	neutral	4.29	neutral	-2.34	deleterious	-3.72	medium_impact	3.15	0.81	neutral	0.12	damaging	3.92	23.50	deleterious	0.06	0.35	0.86	disease	0.53	disease	0.61	disease	0.64	disease	3	0.97	neutral	0.13	neutral	1	deleterious	0.75	deleterious	-1.97	low_impact	-0.13	medium_impact	1.51	medium_impact	0.38	0.8	NA	NA	0.28	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4857	4857	C	A	MI.13578	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	388	130	L	I	Ctt/Att	-5.27	0	0	benign	0.15	neutral	0.4	neutral	4.3	neutral	-2.28	neutral	-1.61	low_impact	1.33	0.91	neutral	0.84	neutral	2.93	22.00	deleterious	0.14	0.4	0.47	neutral	0.21	neutral	0.37	neutral	0.35	neutral	3	0.53	neutral	0.63	deleterious	-6	neutral	0.27	neutral	-0.11	medium_impact	0.11	medium_impact	-0.03	medium_impact	0.36	0.8	NA	NA	0.44	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4858	4858	T	A	MI.13579	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	389	130	L	H	cTt/cAt	-2.73	0	0	probably_damaging	0.99	neutral	0.06	neutral	4.43	neutral	-1.01	deleterious	-6.62	high_impact	3.94	0.87	neutral	0.1	damaging	3.95	23.60	deleterious	0.02	0.35	0.94	disease	0.71	disease	0.69	disease	0.68	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-2.62	low_impact	-0.46	medium_impact	2.17	high_impact	0.28	0.8	NA	NA	0.34	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9163	9163	G	T	MI.1358	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	637	213	V	F	Gtt/Ttt	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	3.07	deleterious	-6.93	deleterious	-4.41	high_impact	3.94	0.66	neutral	0.54	neutral	3.97	23.60	deleterious	0.11	0.65	NA	NA	0.96	disease	0.74	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.28	high_impact	0.45	0.9	48.23	8.71	0.4	N	0.98	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4858	4858	T	G	MI.13580	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	389	130	L	R	cTt/cGt	-2.73	0	0	probably_damaging	0.98	neutral	0.07	neutral	4.22	deleterious	-4.43	deleterious	-5.72	high_impact	3.94	0.91	neutral	0.13	damaging	4.02	23.60	deleterious	0.01	0.35	0.92	disease	0.8	disease	0.74	disease	0.67	disease	3	0.99	deleterious	0.05	neutral	2	deleterious	0.86	deleterious	-2.34	low_impact	-0.42	medium_impact	2.17	high_impact	0.20	0.8	NA	NA	0.44	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4858	4858	T	C	MI.13581	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	389	130	L	P	cTt/cCt	-2.73	0	0	probably_damaging	0.98	neutral	0.11	neutral	4.21	deleterious	-5.09	deleterious	-6.59	high_impact	3.94	0.85	neutral	0.1	damaging	3.71	23.30	deleterious	0.01	0.35	0.93	disease	0.76	disease	0.75	disease	0.69	disease	4	0.99	deleterious	0.07	neutral	2	deleterious	0.84	deleterious	-2.34	low_impact	-0.3	medium_impact	2.17	high_impact	0.36	0.8	NA	NA	0.34	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4860	4860	C	T	MI.13582	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	391	131	L	F	Ctc/Ttc	-7.11	0	0	probably_damaging	1	neutral	0.71	neutral	4.58	neutral	-1.72	deleterious	-3.91	medium_impact	2.64	0.74	neutral	0.04	damaging	3.97	23.60	deleterious	0.16	0.45	0.74	disease	0.48	neutral	0.49	neutral	0.58	disease	2	1	deleterious	0.36	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.42	medium_impact	1.08	medium_impact	0.48	0.8	NA	NA	0.19	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4860	4860	C	G	MI.13583	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	391	131	L	V	Ctc/Gtc	-7.11	0	0	probably_damaging	1	neutral	0.5	neutral	4.62	neutral	-0.42	deleterious	-2.93	medium_impact	2.4	0.7	neutral	0.11	damaging	3.41	23.00	deleterious	0.24	0.45	0.45	neutral	0.32	neutral	0.4	neutral	0.46	neutral	1	1	deleterious	0.25	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	0.21	medium_impact	0.88	medium_impact	0.46	0.8	NA	NA	0.26	N	0.77	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4860	4860	C	A	MI.13584	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	391	131	L	I	Ctc/Atc	-7.11	0	0	probably_damaging	1	neutral	0.4	neutral	4.61	neutral	-0.78	neutral	-1.95	medium_impact	2.35	0.67	neutral	0.06	damaging	4.08	23.70	deleterious	0.23	0.45	0.54	disease	0.35	neutral	0.42	neutral	0.55	disease	1	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.11	medium_impact	0.83	medium_impact	0.48	0.8	NA	NA	0.28	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4861	4861	T	A	MI.13585	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	392	131	L	H	cTc/cAc	-0.66	0	0	probably_damaging	1	neutral	0.54	neutral	4.57	neutral	-2.22	deleterious	-6.84	medium_impact	3.44	0.65	neutral	0.05	damaging	3.99	23.60	deleterious	0.06	0.35	0.78	disease	0.62	disease	0.66	disease	0.69	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.25	medium_impact	1.75	medium_impact	0.26	0.8	NA	NA	0.25	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4861	4861	T	G	MI.13586	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	392	131	L	R	cTc/cGc	-0.66	0	0	probably_damaging	1	neutral	0.35	neutral	4.59	neutral	-1.3	deleterious	-5.86	medium_impact	3.44	0.61	neutral	0.05	damaging	4.11	23.70	deleterious	0.03	0.35	0.74	disease	0.8	disease	0.64	disease	0.69	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.06	medium_impact	1.75	medium_impact	0.30	0.8	NA	NA	0.26	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4861	4861	T	C	MI.13587	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	392	131	L	P	cTc/cCc	-0.66	0	0	probably_damaging	1	neutral	0.21	neutral	4.57	neutral	-2.35	deleterious	-6.84	medium_impact	3.44	0.58	damaging	0.04	damaging	3.86	23.50	deleterious	0.03	0.35	0.76	disease	0.82	disease	0.64	disease	0.69	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	-0.11	medium_impact	1.75	medium_impact	0.24	0.8	NA	NA	0.26	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4863	4863	A	G	MI.13588	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	394	132	T	A	Aca/Gca	-16.09	0	0	probably_damaging	1	neutral	0.78	neutral	4.69	neutral	-0.04	deleterious	-4.92	high_impact	4.12	0.72	neutral	0.09	damaging	3.44	23.00	deleterious	0.13	0.4	0.65	disease	0.5	neutral	0.67	disease	0.64	disease	3	1	deleterious	0.39	neutral	2	deleterious	0.74	deleterious	-3.54	low_impact	0.51	medium_impact	2.32	high_impact	0.32	0.8	NA	NA	0.26	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4863	4863	A	T	MI.13589	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	394	132	T	S	Aca/Tca	-16.09	0	0	probably_damaging	1	neutral	0.66	neutral	4.57	neutral	-1.41	deleterious	-3.93	medium_impact	2.35	0.71	neutral	0.12	damaging	3.21	22.70	deleterious	0.28	0.45	0.7	disease	0.57	disease	0.64	disease	0.63	disease	3	1	deleterious	0.33	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.37	medium_impact	0.83	medium_impact	0.65	0.8	NA	NA	0.22	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9164	9164	T	A	MI.1359	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	638	213	V	D	gTt/gAt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	3.05	deleterious	-9.14	deleterious	-6.21	high_impact	4.5	0.71	neutral	0.55	neutral	4.51	24.30	deleterious	0.08	0.65	NA	NA	0.94	disease	0.81	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.76	high_impact	0.44	0.9	48.23	8.71	0.5	P	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4863	4863	A	C	MI.13590	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	394	132	T	P	Aca/Cca	-16.09	0	0	probably_damaging	1	neutral	0.34	neutral	4.45	deleterious	-4.32	deleterious	-5.9	high_impact	3.78	0.67	neutral	0.08	damaging	3.45	23.00	deleterious	0.03	0.35	0.9	disease	0.75	disease	0.81	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.05	medium_impact	2.04	high_impact	0.48	0.8	NA	NA	0.33	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4864	4864	C	A	MI.13591	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	395	132	T	K	aCa/aAa	8.55	1	0	probably_damaging	1	neutral	0.65	neutral	4.48	neutral	-2.32	deleterious	-5.9	high_impact	4.12	0.72	neutral	0.06	damaging	4.49	24.30	deleterious	0.04	0.35	0.83	disease	0.77	disease	0.8	disease	0.69	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.36	medium_impact	2.32	high_impact	0.46	0.8	NA	NA	0.64	P	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4864	4864	C	T	MI.13592	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	395	132	T	M	aCa/aTa	8.55	1	0	probably_damaging	1	neutral	0.3	neutral	4.46	neutral	-2.98	deleterious	-5.9	high_impact	3.58	0.72	neutral	0.06	damaging	4.03	23.70	deleterious	0.05	0.35	0.62	disease	0.73	disease	0.72	disease	0.67	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.74	deleterious	-3.54	low_impact	0	medium_impact	1.87	medium_impact	0.52	0.8	NA	NA	0.62	P	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4866	4866	T	C	MI.13593	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	397	133	W	R	Tga/Cga	-4.35	0	0	probably_damaging	1	neutral	0.31	neutral	4.58	neutral	-1.97	deleterious	-13.77	high_impact	4.04	0.68	neutral	0.04	damaging	3.52	23.10	deleterious	0.04	0.35	0.78	disease	0.87	disease	0.81	disease	0.71	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	0.02	medium_impact	2.26	high_impact	0.23	0.8	NA	NA	0.47	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4866	4866	T	G	MI.13594	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	397	133	W	G	Tga/Gga	-4.35	0	0	probably_damaging	1	neutral	0.35	neutral	4.58	neutral	-2.03	deleterious	-12.79	high_impact	3.69	0.7	neutral	0.06	damaging	3.90	23.50	deleterious	0.06	0.35	0.77	disease	0.76	disease	0.78	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.06	medium_impact	1.96	medium_impact	0.17	0.8	NA	NA	0.41	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4867	4867	G	T	MI.13595	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	398	133	W	L	tGa/tTa	2.33	0.99	0	probably_damaging	1	neutral	0.94	neutral	4.83	neutral	1.72	deleterious	-12.79	medium_impact	2.39	0.77	neutral	0.1	damaging	4.19	23.80	deleterious	0.07	0.35	0.77	disease	0.74	disease	0.72	disease	0.47	neutral	1	1	deleterious	0.47	deleterious	1	deleterious	0.79	deleterious	-3.54	low_impact	0.87	medium_impact	0.87	medium_impact	0.17	0.8	NA	NA	0.38	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4867	4867	G	C	MI.13596	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	398	133	W	S	tGa/tCa	2.33	0.99	0	probably_damaging	1	neutral	0.48	neutral	4.6	neutral	-1.01	deleterious	-13.77	high_impact	4.04	0.7	neutral	0.05	damaging	3.95	23.60	deleterious	0.06	0.35	0.65	disease	0.81	disease	0.76	disease	0.7	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.19	medium_impact	2.26	high_impact	0.17	0.8	NA	NA	0.52	N	0.94	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4868	4868	A	T	MI.13597	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	399	133	W	C	tgA/tgT	5.78	1	0	probably_damaging	1	neutral	0.22	neutral	4.57	neutral	-2.34	deleterious	-12.79	high_impact	3.69	0.67	neutral	0.04	damaging	4.05	23.70	deleterious	0.05	0.35	0.97	disease	0.83	disease	0.81	disease	0.75	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.1	medium_impact	1.96	medium_impact	0.26	0.8	NA	NA	0.63	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4868	4868	A	C	MI.13598	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	399	133	W	C	tgA/tgC	5.78	1	0	probably_damaging	1	neutral	0.22	neutral	4.57	neutral	-2.34	deleterious	-12.79	high_impact	3.69	0.67	neutral	0.04	damaging	3.96	23.60	deleterious	0.05	0.35	0.97	disease	0.83	disease	0.81	disease	0.75	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.1	medium_impact	1.96	medium_impact	0.26	0.8	NA	NA	0.62	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4869	4869	C	A	MI.13599	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	400	134	Q	K	Caa/Aaa	2.1	1	0	probably_damaging	0.99	neutral	0.37	neutral	4.57	neutral	-1.65	deleterious	-3.93	high_impact	4.1	0.84	neutral	0.1	damaging	3.87	23.50	deleterious	0.11	0.4	0.47	neutral	0.84	disease	0.74	disease	0.71	disease	4	0.99	deleterious	0.19	neutral	2	deleterious	0.79	deleterious	-2.62	low_impact	0.08	medium_impact	2.31	high_impact	0.33	0.8	NA	NA	0.51	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8590	8590	C	G	MI.136	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	64	22	L	V	Ctg/Gtg	-15.14	0	0	benign	0.32	neutral	0.14	neutral	4.22	neutral	-1.26	neutral	-1.09	low_impact	1.14	0.9	neutral	0.81	neutral	0.35	6.17	deleterious	0.31	0.65	0.42	neutral	0.34	neutral	0.37	neutral	0.46	neutral	1	0.83	neutral	0.41	neutral	-6	neutral	0.36	neutral	-0.45	medium_impact	-0.15	medium_impact	-0.12	medium_impact	0.59	0.9	25.22	20.33	0.49	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9164	9164	T	C	MI.1360	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	638	213	V	A	gTt/gCt	6.14	1	0	probably_damaging	0.99	deleterious	0	neutral	3.07	deleterious	-5.96	deleterious	-3.54	high_impact	4.5	0.69	neutral	0.64	neutral	3.53	23.10	deleterious	0.15	0.65	NA	NA	0.74	disease	0.7	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.65	low_impact	-1.4	low_impact	2.76	high_impact	0.27	0.9	48.23	8.71	0.51	P	0.60	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4869	4869	C	G	MI.13600	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	400	134	Q	E	Caa/Gaa	2.1	1	0	probably_damaging	0.99	neutral	0.33	neutral	4.57	neutral	-1.82	deleterious	-2.95	high_impact	4.1	0.87	neutral	0.11	damaging	3.02	22.30	deleterious	0.22	0.45	0.65	disease	0.79	disease	0.72	disease	0.68	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.81	deleterious	-2.62	low_impact	0.04	medium_impact	2.31	high_impact	0.46	0.8	NA	NA	0.49	N	0.90	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4870	4870	A	G	MI.13601	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	401	134	Q	R	cAa/cGa	2.79	1	0	probably_damaging	0.99	neutral	0.37	neutral	4.57	neutral	-1.93	deleterious	-3.93	high_impact	4.1	0.83	neutral	0.11	damaging	3.16	22.60	deleterious	0.15	0.4	0.55	disease	0.86	disease	0.76	disease	0.71	disease	4	0.99	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-2.62	low_impact	0.08	medium_impact	2.31	high_impact	0.14	0.8	NA	NA	0.57	P	0.87	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4870	4870	A	C	MI.13602	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	401	134	Q	P	cAa/cCa	2.79	1	0	probably_damaging	1	neutral	0.24	neutral	4.61	neutral	-0.58	deleterious	-5.9	high_impact	3.75	0.83	neutral	0.1	damaging	3.06	22.40	deleterious	0.04	0.35	0.79	disease	0.91	disease	0.79	disease	0.69	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.07	medium_impact	2.01	high_impact	0.20	0.8	NA	NA	0.53	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4870	4870	A	T	MI.13603	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	401	134	Q	L	cAa/cTa	2.79	1	0	probably_damaging	1	neutral	0.69	neutral	5.05	neutral	2.47	deleterious	-6.88	medium_impact	3.29	0.87	neutral	0.12	damaging	3.50	23.10	deleterious	0.07	0.35	0.82	disease	0.88	disease	0.63	disease	0.6	disease	2	1	deleterious	0.35	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.4	medium_impact	1.63	medium_impact	0.13	0.8	NA	NA	0.41	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4871	4871	A	C	MI.13604	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	402	134	Q	H	caA/caC	5.32	1	0	probably_damaging	1	neutral	0.54	neutral	4.56	neutral	-2.63	deleterious	-4.92	high_impact	4.1	0.85	neutral	0.09	damaging	3.34	22.90	deleterious	0.15	0.4	0.44	neutral	0.78	disease	0.75	disease	0.68	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.25	medium_impact	2.31	high_impact	0.50	0.8	NA	NA	0.57	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4871	4871	A	T	MI.13605	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	402	134	Q	H	caA/caT	5.32	1	0	probably_damaging	1	neutral	0.54	neutral	4.56	neutral	-2.63	deleterious	-4.92	high_impact	4.1	0.85	neutral	0.09	damaging	3.47	23.00	deleterious	0.15	0.4	0.44	neutral	0.78	disease	0.75	disease	0.68	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.25	medium_impact	2.31	high_impact	0.50	0.8	NA	NA	0.57	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4872	4872	A	G	MI.13606	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	403	135	K	E	Aaa/Gaa	4.63	1	0	probably_damaging	1	neutral	0.38	neutral	4.35	deleterious	-4.32	deleterious	-3.93	high_impact	3.82	0.84	neutral	0.39	neutral	3.71	23.30	deleterious	0.08	0.35	0.52	disease	0.85	disease	0.68	disease	0.69	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.09	medium_impact	2.07	high_impact	0.33	0.8	NA	NA	0.63	P	0.91	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4872	4872	A	C	MI.13607	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	403	135	K	Q	Aaa/Caa	4.63	1	0	probably_damaging	1	neutral	0.36	neutral	4.34	deleterious	-4.44	deleterious	-3.93	high_impact	4.17	0.84	neutral	0.44	neutral	3.21	22.70	deleterious	0.13	0.4	0.65	disease	0.79	disease	0.67	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.07	medium_impact	2.37	high_impact	0.35	0.8	NA	NA	0.64	P	0.88	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4873	4873	A	C	MI.13608	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	404	135	K	T	aAa/aCa	8.55	1	0	probably_damaging	1	neutral	0.46	neutral	4.37	deleterious	-3.21	deleterious	-5.9	high_impact	3.82	0.83	neutral	0.41	neutral	3.49	23.10	deleterious	0.07	0.35	0.52	disease	0.8	disease	0.69	disease	0.66	disease	3	1	deleterious	0.23	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.17	medium_impact	2.07	high_impact	0.20	0.8	NA	NA	0.62	P	0.81	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4873	4873	A	T	MI.13609	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	404	135	K	M	aAa/aTa	8.55	1	0	probably_damaging	1	neutral	0.24	neutral	4.36	deleterious	-3.44	deleterious	-5.9	high_impact	4.17	0.92	neutral	0.54	neutral	3.71	23.30	deleterious	0.06	0.35	0.59	disease	0.83	disease	0.68	disease	0.68	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	-0.07	medium_impact	2.37	high_impact	0.20	0.8	NA	NA	0.68	P	0.45	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9164	9164	T	G	MI.1361	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	638	213	V	G	gTt/gGt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	3.05	deleterious	-8.56	deleterious	-6.23	high_impact	4.5	0.68	neutral	0.66	neutral	3.86	23.50	deleterious	0.11	0.65	NA	NA	0.9	disease	0.73	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.76	high_impact	0.33	0.9	48.23	8.71	0.45	N	0.93	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4874	4874	A	T	MI.13610	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	405	135	K	N	aaA/aaT	8.55	1	0	probably_damaging	1	neutral	0.36	neutral	4.34	deleterious	-4.63	deleterious	-4.92	high_impact	4.17	0.81	neutral	0.36	neutral	3.80	23.40	deleterious	0.14	0.4	0.61	disease	0.81	disease	0.68	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.07	medium_impact	2.37	high_impact	0.21	0.8	NA	NA	0.64	P	0.69	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4874	4874	A	C	MI.13611	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	405	135	K	N	aaA/aaC	8.55	1	0	probably_damaging	1	neutral	0.36	neutral	4.34	deleterious	-4.63	deleterious	-4.92	high_impact	4.17	0.81	neutral	0.36	neutral	3.75	23.30	deleterious	0.14	0.4	0.61	disease	0.81	disease	0.68	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.07	medium_impact	2.37	high_impact	0.21	0.8	NA	NA	0.64	P	0.69	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4875	4875	C	A	MI.13612	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	406	136	L	M	Cta/Ata	4.63	1	0	probably_damaging	1	neutral	0.32	neutral	4.54	neutral	-1.57	neutral	-1.6	medium_impact	2.02	0.93	neutral	0.26	damaging	3.84	23.40	deleterious	0.35	0.5	0.83	disease	0.57	disease	0.49	neutral	0.52	disease	0	1	deleterious	0.16	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.03	medium_impact	0.56	medium_impact	0.64	0.8	NA	NA	0.57	P	0.18	polymorphism	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4875	4875	C	G	MI.13613	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	406	136	L	V	Cta/Gta	4.63	1	0	probably_damaging	1	neutral	0.45	neutral	4.69	neutral	0.16	neutral	-1.51	low_impact	1.57	0.93	neutral	0.47	neutral	2.25	17.87	deleterious	0.31	0.45	0.68	disease	0.59	disease	0.49	neutral	0.35	neutral	3	1	deleterious	0.23	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	0.16	medium_impact	0.18	medium_impact	0.44	0.8	NA	NA	0.52	N	0.42	polymorphism	0.97	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4876	4876	T	G	MI.13614	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	407	136	L	R	cTa/cGa	-1.58	0	0	probably_damaging	1	neutral	0.27	neutral	4.53	deleterious	-3.94	deleterious	-5.53	medium_impact	3.26	0.81	neutral	0.12	damaging	4.20	23.90	deleterious	0.04	0.35	0.59	disease	0.9	disease	0.73	disease	0.73	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.03	medium_impact	1.6	medium_impact	0.15	0.8	NA	NA	0.28	N	0.92	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4876	4876	T	C	MI.13615	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	407	136	L	P	cTa/cCa	-1.58	0	0	probably_damaging	1	neutral	0.29	neutral	4.52	deleterious	-4.51	deleterious	-6.16	medium_impact	3.26	0.91	neutral	0.14	damaging	3.92	23.50	deleterious	0.04	0.35	0.58	disease	0.88	disease	0.73	disease	0.73	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.01	medium_impact	1.6	medium_impact	0.18	0.8	NA	NA	0.38	N	0.91	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4876	4876	T	A	MI.13616	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	407	136	L	Q	cTa/cAa	-1.58	0	0	probably_damaging	1	neutral	0.26	neutral	4.53	deleterious	-4.08	deleterious	-5.53	medium_impact	3.26	0.86	neutral	0.15	damaging	4.37	24.10	deleterious	0.06	0.35	0.41	neutral	0.77	disease	0.6	disease	0.65	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.04	medium_impact	1.6	medium_impact	0.17	0.8	NA	NA	0.31	N	0.89	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4878	4878	G	T	MI.13617	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	409	137	A	S	Gcc/Tcc	-2.5	0	0	probably_damaging	1	neutral	0.5	neutral	4.23	deleterious	-3.18	deleterious	-2.95	medium_impact	2.64	0.87	neutral	0.11	damaging	2.05	16.51	deleterious	0.15	0.4	0.65	disease	0.78	disease	0.61	disease	0.64	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.21	medium_impact	1.08	medium_impact	0.64	0.8	0.29	6.87	0.26	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4878	4878	G	A	MI.13618	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	409	137	A	T	Gcc/Acc	-2.5	0	0	probably_damaging	1	neutral	0.47	neutral	4.25	deleterious	-4.12	deleterious	-3.93	medium_impact	2.75	0.86	neutral	0.1	damaging	3.88	23.50	deleterious	0.09	0.4	0.59	disease	0.76	disease	0.64	disease	0.64	disease	3	1	deleterious	0.24	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.18	medium_impact	1.17	medium_impact	0.68	0.85	0.29	6.87	0.29	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4878	4878	G	C	MI.13619	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	409	137	A	P	Gcc/Ccc	-2.5	0	0	probably_damaging	1	neutral	0.4	neutral	4.19	deleterious	-6.01	deleterious	-4.92	low_impact	1.76	0.81	neutral	0.24	damaging	1.82	15.09	deleterious	0.03	0.35	0.52	disease	0.39	neutral	0.6	disease	0.48	neutral	0	1	deleterious	0.2	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	0.11	medium_impact	0.34	medium_impact	0.63	0.8	0.29	6.87	0.29	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9166	9166	T	A	MI.1362	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	640	214	F	I	Ttc/Atc	-12.37	0	0	probably_damaging	0.99	neutral	0.07	neutral	2.2	deleterious	-6.85	deleterious	-5.23	high_impact	3.65	0.63	neutral	0.73	neutral	4.48	24.20	deleterious	0.14	0.65	NA	NA	0.86	disease	0.7	disease	0.74	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.87	deleterious	-2.65	low_impact	-0.34	medium_impact	2.03	high_impact	0.41	0.9	49.56	8.9	0.4	N	0.94	disease_causing	0.54	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4879	4879	C	T	MI.13620	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	410	137	A	V	gCc/gTc	5.78	1	0	probably_damaging	1	neutral	0.54	neutral	4.31	deleterious	-3.32	deleterious	-3.93	medium_impact	3.19	0.9	neutral	0.12	damaging	4.09	23.70	deleterious	0.08	0.35	0.82	disease	0.82	disease	0.63	disease	0.65	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.25	medium_impact	1.54	medium_impact	0.68	0.85	0.29	6.87	0.57	P	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4879	4879	C	G	MI.13621	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	410	137	A	G	gCc/gGc	5.78	1	0	probably_damaging	1	neutral	0.36	neutral	4.19	neutral	-2.17	deleterious	-3.93	medium_impact	2.43	0.89	neutral	0.14	damaging	3.53	23.10	deleterious	0.13	0.4	0.81	disease	0.76	disease	0.56	disease	0.61	disease	2	1	deleterious	0.18	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.07	medium_impact	0.9	medium_impact	0.75	0.85	0.29	6.87	0.59	P	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4879	4879	C	A	MI.13622	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	410	137	A	D	gCc/gAc	5.78	1	0	probably_damaging	1	neutral	0.21	neutral	4.18	deleterious	-5.74	deleterious	-5.9	high_impact	3.65	0.83	neutral	0.08	damaging	4.43	24.20	deleterious	0.02	0.35	0.75	disease	0.92	disease	0.74	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.11	medium_impact	1.93	medium_impact	0.31	0.8	0.29	6.87	0.6	P	0.95	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4881	4881	C	T	MI.13623	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	412	138	P	S	Ccc/Tcc	-5.73	0	0	probably_damaging	1	neutral	0.42	neutral	4.55	neutral	-1.12	deleterious	-7.86	high_impact	3.81	0.91	neutral	0.12	damaging	3.89	23.50	deleterious	0.07	0.35	0.42	neutral	0.77	disease	0.68	disease	0.66	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.13	medium_impact	2.06	high_impact	0.15	0.8	NA	NA	0.37	N	0.72	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4881	4881	C	A	MI.13624	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	412	138	P	T	Ccc/Acc	-5.73	0	0	probably_damaging	1	neutral	0.4	neutral	4.51	neutral	-1.87	deleterious	-7.86	high_impact	3.81	0.81	neutral	0.08	damaging	3.69	23.30	deleterious	0.07	0.35	0.65	disease	0.77	disease	0.7	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.11	medium_impact	2.06	high_impact	0.56	0.8	NA	NA	0.31	N	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4881	4881	C	G	MI.13625	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	412	138	P	A	Ccc/Gcc	-5.73	0	0	probably_damaging	1	neutral	0.51	neutral	4.61	neutral	-0.32	deleterious	-7.86	medium_impact	3.46	0.82	neutral	0.13	damaging	3.08	22.50	deleterious	0.09	0.35	0.44	neutral	0.62	disease	0.68	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.22	medium_impact	1.77	medium_impact	0.62	0.8	NA	NA	0.28	N	0.72	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4882	4882	C	G	MI.13626	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	413	138	P	R	cCc/cGc	5.55	1	0	probably_damaging	1	neutral	0.35	neutral	4.5	neutral	-2.41	deleterious	-8.85	high_impact	4.16	0.83	neutral	0.08	damaging	3.58	23.20	deleterious	0.03	0.35	0.39	neutral	0.87	disease	0.79	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.06	medium_impact	2.36	high_impact	0.42	0.8	NA	NA	0.64	P	0.56	polymorphism	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4882	4882	C	A	MI.13627	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	413	138	P	H	cCc/cAc	5.55	1	0	probably_damaging	1	neutral	0.53	neutral	4.48	deleterious	-3.44	deleterious	-8.85	high_impact	4.16	0.91	neutral	0.09	damaging	4.01	23.60	deleterious	0.04	0.35	0.8	disease	0.83	disease	0.79	disease	0.68	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.24	medium_impact	2.36	high_impact	0.35	0.8	NA	NA	0.64	P	0.71	polymorphism	0.99	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4882	4882	C	T	MI.13628	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	413	138	P	L	cCc/cTc	5.55	1	0	probably_damaging	1	neutral	0.71	neutral	4.5	neutral	-2.31	deleterious	-9.83	high_impact	3.6	0.74	neutral	0.08	damaging	4.39	24.10	deleterious	0.04	0.35	0.58	disease	0.85	disease	0.67	disease	0.69	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.42	medium_impact	1.89	medium_impact	0.59	0.8	NA	NA	0.5	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4884	4884	A	T	MI.13629	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	415	139	I	F	Atc/Ttc	-7.8	0	0	benign	0.2	neutral	0.87	neutral	4.53	neutral	0.41	deleterious	-2.58	neutral_impact	-0.1	0.87	neutral	0.74	neutral	0.85	9.76	deleterious	0.17	0.45	0.67	disease	0.41	neutral	0.25	neutral	0.63	disease	3	0.1	neutral	0.84	deleterious	-6	neutral	0.26	neutral	-0.25	medium_impact	0.67	medium_impact	-1.23	low_impact	0.63	0.8	NA	NA	0.25	N	0.44	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9166	9166	T	C	MI.1363	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	640	214	F	L	Ttc/Ctc	-12.37	0	0	probably_damaging	0.98	deleterious	0.03	neutral	2.24	deleterious	-6.92	deleterious	-5.2	high_impact	3.58	0.54	damaging	0.64	neutral	4.11	23.70	deleterious	0.19	0.65	NA	NA	0.87	disease	0.65	disease	0.67	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.85	deleterious	-2.36	low_impact	-0.56	medium_impact	1.97	medium_impact	0.48	0.9	49.56	8.9	0.4	N	0.89	disease_causing	0.57	0.38	rs1057516063	Likely_pathogenic	Optic_neuropathy	354304	Human_Phenotype_Ontology:HP:0001138,MedGen:C3887709	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	4884	4884	A	C	MI.13630	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	415	139	I	L	Atc/Ctc	-7.8	0	0	benign	0	neutral	1	neutral	4.82	neutral	-0.05	neutral	0.4	neutral_impact	-1.21	0.9	neutral	0.95	neutral	-0.84	0.04	neutral	0.27	0.45	0.37	neutral	0.19	neutral	0.19	neutral	0.35	neutral	3	0	neutral	1	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	1.87	high_impact	-2.16	low_impact	0.64	0.8	NA	NA	0.38	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4884	4884	A	G	MI.13631	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	415	139	I	V	Atc/Gtc	-7.8	0	0	benign	0.05	neutral	0.34	neutral	4.65	neutral	0.05	neutral	-0.89	low_impact	1.24	0.95	neutral	0.8	neutral	1.07	11.05	neutral	0.46	0.55	0.38	neutral	0.25	neutral	0.31	neutral	0.46	neutral	1	0.63	neutral	0.65	deleterious	-6	neutral	0.13	neutral	0.37	medium_impact	0.05	medium_impact	-0.1	medium_impact	0.49	0.8	NA	NA	0.42	N	0.63	polymorphism	1	0.02	rs879155022	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4885	4885	T	G	MI.13632	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	416	139	I	S	aTc/aGc	-3.65	0	0	benign	0.13	neutral	0.41	neutral	4.48	neutral	-2.88	deleterious	-4.48	low_impact	1.94	0.87	neutral	0.53	neutral	2.35	18.51	deleterious	0.03	0.35	0.36	neutral	0.64	disease	0.53	disease	0.61	disease	2	0.52	neutral	0.64	deleterious	-6	neutral	0.21	neutral	-0.04	medium_impact	0.12	medium_impact	0.49	medium_impact	0.28	0.8	NA	NA	0.34	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4885	4885	T	C	MI.13633	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	416	139	I	T	aTc/aCc	-3.65	0	0	benign	0.01	neutral	0.33	neutral	4.52	neutral	-2.31	deleterious	-3.59	neutral_impact	0.19	0.92	neutral	0.95	neutral	0.16	4.23	deleterious	0.07	0.35	0.67	disease	0.33	neutral	0.33	neutral	0.62	disease	2	0.66	neutral	0.66	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.04	medium_impact	-0.98	medium_impact	0.35	0.8	NA	NA	0.42	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4885	4885	T	A	MI.13634	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	416	139	I	N	aTc/aAc	-3.65	0	0	benign	0.36	neutral	0.13	neutral	4.46	deleterious	-4.13	deleterious	-5.46	medium_impact	2.28	0.9	neutral	0.46	neutral	2.50	19.46	deleterious	0.09	0.35	0.65	disease	0.69	disease	0.55	disease	0.66	disease	3	0.85	neutral	0.39	neutral	-3	neutral	0.36	neutral	-0.57	medium_impact	-0.25	medium_impact	0.78	medium_impact	0.33	0.8	NA	NA	0.42	N	0.86	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4886	4886	C	G	MI.13635	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	417	139	I	M	atC/atG	4.63	0.66	0	benign	0.01	neutral	0.43	neutral	4.53	neutral	-2.11	neutral	-0.74	neutral_impact	-0.64	0.94	neutral	0.94	neutral	-0.27	0.78	neutral	0.28	0.45	0.59	disease	0.1	neutral	0.17	neutral	0.29	neutral	4	0.56	neutral	0.71	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.14	medium_impact	-1.68	low_impact	0.52	0.8	NA	NA	0.45	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4886	4886	C	A	MI.13636	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	417	139	I	M	atC/atA	4.63	0.66	0	benign	0.01	neutral	0.43	neutral	4.53	neutral	-2.11	neutral	-0.74	neutral_impact	-0.64	0.94	neutral	0.94	neutral	0.15	4.11	deleterious	0.28	0.45	0.59	disease	0.1	neutral	0.17	neutral	0.29	neutral	4	0.56	neutral	0.71	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.14	medium_impact	-1.68	low_impact	0.52	0.8	NA	NA	0.46	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4887	4887	T	G	MI.13637	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	418	140	S	A	Tca/Gca	-9.87	0	0	possibly_damaging	0.51	neutral	0.69	neutral	4.71	neutral	0.87	deleterious	-2.54	neutral_impact	0.71	0.87	neutral	0.94	neutral	2.35	18.48	deleterious	0.24	0.45	0.41	neutral	0.12	neutral	0.31	neutral	0.25	neutral	5	0.41	neutral	0.59	deleterious	-3	neutral	0.56	deleterious	-0.81	medium_impact	0.4	medium_impact	-0.55	medium_impact	0.54	0.8	2.02	7.8	0.34	N	0.28	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4887	4887	T	A	MI.13638	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	418	140	S	T	Tca/Aca	-9.87	0	0	possibly_damaging	0.7	neutral	0.49	neutral	4.62	neutral	-0.55	neutral	-2.22	neutral_impact	0.73	0.88	neutral	0.97	neutral	2.52	19.58	deleterious	0.25	0.45	0.43	neutral	0.13	neutral	0.32	neutral	0.27	neutral	5	0.67	neutral	0.4	neutral	-3	neutral	0.62	deleterious	-1.13	low_impact	0.2	medium_impact	-0.53	medium_impact	0.52	0.8	2.02	7.8	0.4	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4887	4887	T	C	MI.13639	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	418	140	S	P	Tca/Cca	-9.87	0	0	probably_damaging	0.95	neutral	0.22	neutral	4.58	neutral	-2.46	deleterious	-4.46	medium_impact	3.21	0.75	neutral	0.35	neutral	3.95	23.60	deleterious	0.05	0.35	0.84	disease	0.87	disease	0.73	disease	0.69	disease	4	0.96	neutral	0.14	neutral	1	deleterious	0.87	deleterious	-1.97	low_impact	-0.1	medium_impact	1.56	medium_impact	0.37	0.8	2.02	7.8	0.32	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9166	9166	T	G	MI.1364	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	640	214	F	V	Ttc/Gtc	-12.37	0	0	probably_damaging	0.99	deleterious	0.03	neutral	2.24	deleterious	-7.94	deleterious	-6.12	high_impact	4.2	0.52	damaging	0.63	neutral	4.17	23.80	deleterious	0.16	0.65	NA	NA	0.9	disease	0.71	disease	0.77	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-0.56	medium_impact	2.5	high_impact	0.33	0.9	49.56	8.9	0.42	N	0.99	disease_causing	0.72	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4888	4888	C	G	MI.13640	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	419	140	S	W	tCa/tGa	-0.2	0	0	probably_damaging	0.96	neutral	0.19	neutral	4.6	neutral	-1.25	deleterious	-6.18	medium_impact	2.4	0.88	neutral	0.41	neutral	4.32	24.00	deleterious	0.05	0.35	0.88	disease	0.85	disease	0.66	disease	0.66	disease	3	0.98	neutral	0.12	neutral	1	deleterious	0.83	deleterious	-2.06	low_impact	-0.14	medium_impact	0.88	medium_impact	0.18	0.8	2.02	7.8	0.36	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4888	4888	C	T	MI.13641	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	419	140	S	L	tCa/tTa	-0.2	0	0	benign	0.03	neutral	0.87	neutral	4.67	neutral	0.45	deleterious	-5.04	low_impact	1.43	0.93	neutral	0.52	neutral	4.58	24.40	deleterious	0.08	0.35	0.67	disease	0.75	disease	0.6	disease	0.66	disease	3	0.06	neutral	0.92	deleterious	-6	neutral	0.27	neutral	0.59	medium_impact	0.67	medium_impact	0.06	medium_impact	0.40	0.8	2.02	7.8	0.23	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4890	4890	A	G	MI.13642	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	421	141	I	V	Atc/Gtc	-8.95	0	0	probably_damaging	0.99	neutral	0.28	neutral	4.6	neutral	0.26	neutral	-0.46	low_impact	0.96	0.91	neutral	0.9	neutral	1.55	13.60	neutral	0.52	0.6	0.51	disease	0.26	neutral	0.44	neutral	0.31	neutral	4	0.99	deleterious	0.15	neutral	-2	neutral	0.67	deleterious	-2.62	low_impact	-0.02	medium_impact	-0.34	medium_impact	0.49	0.8	NA	NA	0.47	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4890	4890	A	C	MI.13643	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	421	141	I	L	Atc/Ctc	-8.95	0	0	probably_damaging	0.99	neutral	1	neutral	4.87	neutral	1.06	neutral	-1.82	neutral_impact	-0.53	0.86	neutral	0.95	neutral	2.25	17.82	deleterious	0.24	0.45	0.56	disease	0.13	neutral	0.33	neutral	0.26	neutral	5	0.99	deleterious	0.51	deleterious	-2	neutral	0.66	deleterious	-2.62	low_impact	1.87	high_impact	-1.59	low_impact	0.59	0.8	NA	NA	0.29	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4890	4890	A	T	MI.13644	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	421	141	I	F	Atc/Ttc	-8.95	0	0	probably_damaging	1	neutral	0.27	neutral	4.5	neutral	-0.81	deleterious	-3.83	medium_impact	1.97	0.85	neutral	0.45	neutral	3.85	23.40	deleterious	0.12	0.4	0.75	disease	0.72	disease	0.65	disease	0.69	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.03	medium_impact	0.51	medium_impact	0.44	0.8	NA	NA	0.3	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4891	4891	T	A	MI.13645	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	422	141	I	N	aTc/aAc	-1.12	0	0	probably_damaging	1	neutral	0.1	neutral	4.55	deleterious	-3.78	deleterious	-6.49	medium_impact	3.06	0.88	neutral	0.39	neutral	4.54	24.30	deleterious	0.06	0.35	0.77	disease	0.8	disease	0.66	disease	0.72	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.32	medium_impact	1.43	medium_impact	0.38	0.8	NA	NA	0.38	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4891	4891	T	C	MI.13646	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	422	141	I	T	aTc/aCc	-1.12	0	0	probably_damaging	1	neutral	0.11	neutral	4.51	neutral	-1.96	deleterious	-4.3	medium_impact	2.37	0.89	neutral	0.44	neutral	3.44	23.00	deleterious	0.06	0.35	0.71	disease	0.61	disease	0.61	disease	0.68	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.3	medium_impact	0.85	medium_impact	0.28	0.8	NA	NA	0.47	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4891	4891	T	G	MI.13647	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	422	141	I	S	aTc/aGc	-1.12	0	0	probably_damaging	1	neutral	0.33	neutral	4.5	neutral	-2.72	deleterious	-5.51	medium_impact	2.71	0.84	neutral	0.43	neutral	4.25	23.90	deleterious	0.03	0.35	0.48	neutral	0.76	disease	0.63	disease	0.7	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.04	medium_impact	1.14	medium_impact	0.31	0.8	NA	NA	0.26	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4892	4892	C	A	MI.13648	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	423	141	I	M	atC/atA	5.78	0.87	0	probably_damaging	1	neutral	0.11	neutral	4.53	neutral	-1.3	deleterious	-2.54	low_impact	1.2	0.9	neutral	0.64	neutral	3.84	23.40	deleterious	0.23	0.45	0.79	disease	0.49	neutral	0.56	disease	0.64	disease	3	1	deleterious	0.06	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	-0.3	medium_impact	-0.13	medium_impact	0.57	0.8	NA	NA	0.57	P	0.67	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4892	4892	C	G	MI.13649	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	423	141	I	M	atC/atG	5.78	0.87	0	probably_damaging	1	neutral	0.11	neutral	4.53	neutral	-1.3	deleterious	-2.54	low_impact	1.2	0.9	neutral	0.64	neutral	3.34	22.90	deleterious	0.23	0.45	0.79	disease	0.49	neutral	0.56	disease	0.64	disease	3	1	deleterious	0.06	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	-0.3	medium_impact	-0.13	medium_impact	0.57	0.8	NA	NA	0.57	P	0.67	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9167	9167	T	C	MI.1365	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	641	214	F	S	tTc/tCc	5.68	1	0	probably_damaging	0.99	deleterious	0	neutral	2.16	deleterious	-7.73	deleterious	-7.04	high_impact	4.2	0.5	damaging	0.8	neutral	4.36	24.10	deleterious	0.14	0.65	NA	NA	0.89	disease	0.69	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.65	low_impact	-1.4	low_impact	2.5	high_impact	0.28	0.9	49.56	8.9	0.47	N	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4893	4893	A	C	MI.13650	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	424	142	M	L	Ata/Cta	-9.87	0	0	benign	0.18	neutral	1	neutral	5.27	neutral	2.7	neutral	0.54	neutral_impact	-1.24	0.88	neutral	0.97	neutral	0.49	7.33	deleterious	0.18	0.45	0.52	disease	0.2	neutral	0.44	neutral	0.25	neutral	5	0.18	neutral	0.91	deleterious	-6	neutral	0.35	neutral	-0.19	medium_impact	1.87	high_impact	-2.19	low_impact	0.34	0.8	0.29	8.23	0.33	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4893	4893	A	T	MI.13651	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	424	142	M	L	Ata/Tta	-9.87	0	0	benign	0.18	neutral	1	neutral	5.27	neutral	2.7	neutral	0.54	neutral_impact	-1.24	0.88	neutral	0.97	neutral	0.56	7.85	deleterious	0.18	0.45	0.52	disease	0.2	neutral	0.44	neutral	0.25	neutral	5	0.18	neutral	0.91	deleterious	-6	neutral	0.35	neutral	-0.19	medium_impact	1.87	high_impact	-2.19	low_impact	0.34	0.8	0.29	8.23	0.33	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4893	4893	A	G	MI.13652	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	424	142	M	V	Ata/Gta	-9.87	0	0	benign	0.25	neutral	0.34	neutral	4.64	neutral	-0.01	neutral	-1.64	low_impact	1.38	0.84	neutral	0.24	damaging	2.69	20.80	deleterious	0.14	0.4	0.49	neutral	0.62	disease	0.62	disease	0.7	disease	4	0.59	neutral	0.55	deleterious	-6	neutral	0.49	deleterious	-0.36	medium_impact	0.05	medium_impact	0.02	medium_impact	0.41	0.8	0.29	8.23	0.27	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4894	4894	T	C	MI.13653	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	425	142	M	T	aTa/aCa	-1.35	0	0	possibly_damaging	0.74	neutral	0.3	neutral	4.52	neutral	-2.45	deleterious	-3.65	low_impact	1.29	0.89	neutral	0.27	damaging	2.92	21.90	deleterious	0.05	0.35	0.4	neutral	0.62	disease	0.68	disease	0.71	disease	4	0.8	neutral	0.28	neutral	-3	neutral	0.70	deleterious	-1.21	low_impact	0	medium_impact	-0.06	medium_impact	0.26	0.8	0.29	8.23	0.36	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4894	4894	T	A	MI.13654	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	425	142	M	K	aTa/aAa	-1.35	0	0	probably_damaging	0.91	neutral	0.39	neutral	4.5	deleterious	-3.86	deleterious	-4.41	medium_impact	2.23	0.82	neutral	0.19	damaging	3.93	23.50	deleterious	0.02	0.35	0.71	disease	0.76	disease	0.75	disease	0.72	disease	4	0.91	neutral	0.24	neutral	1	deleterious	0.83	deleterious	-1.72	low_impact	0.1	medium_impact	0.73	medium_impact	0.22	0.8	0.29	8.23	0.26	N	0.93	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4895	4895	A	T	MI.13655	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	426	142	M	I	atA/atT	7.4	0.95	0.04	benign	0.07	neutral	0.47	neutral	4.73	neutral	0.66	neutral	-0.95	neutral_impact	0.26	0.87	neutral	0.52	neutral	2.22	17.61	deleterious	0.17	0.45	0.53	disease	0.38	neutral	0.48	neutral	0.38	neutral	2	0.47	neutral	0.7	deleterious	-6	neutral	0.29	neutral	0.23	medium_impact	0.18	medium_impact	-0.93	medium_impact	0.48	0.8	0.29	8.23	0.56	N	0.49	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4895	4895	A	C	MI.13656	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	426	142	M	I	atA/atC	7.4	0.95	0.04	benign	0.07	neutral	0.47	neutral	4.73	neutral	0.66	neutral	-0.95	neutral_impact	0.26	0.87	neutral	0.52	neutral	2.12	16.95	deleterious	0.17	0.45	0.53	disease	0.38	neutral	0.48	neutral	0.38	neutral	2	0.47	neutral	0.7	deleterious	-6	neutral	0.29	neutral	0.23	medium_impact	0.18	medium_impact	-0.93	medium_impact	0.48	0.8	0.29	8.23	0.55	N	0.49	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4896	4896	T	A	MI.13657	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	427	143	Y	N	Tac/Aac	-4.81	0	0	possibly_damaging	0.9	neutral	0.17	neutral	4.62	neutral	-2.97	deleterious	-6.89	medium_impact	2	0.86	neutral	0.16	damaging	3.96	23.60	deleterious	0.06	0.35	0.7	disease	0.67	disease	0.61	disease	0.68	disease	4	0.94	neutral	0.14	neutral	0	NA	0.76	deleterious	-1.67	low_impact	-0.17	medium_impact	0.54	medium_impact	0.37	0.8	1.73	6.88	0.3	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4896	4896	T	G	MI.13658	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	427	143	Y	D	Tac/Gac	-4.81	0	0	possibly_damaging	0.87	neutral	0.09	neutral	4.56	deleterious	-4.28	deleterious	-7.8	medium_impact	3.04	0.85	neutral	0.11	damaging	3.89	23.50	deleterious	0.04	0.35	0.9	disease	0.78	disease	0.71	disease	0.69	disease	4	0.96	neutral	0.11	neutral	0	NA	0.81	deleterious	-1.55	low_impact	-0.35	medium_impact	1.42	medium_impact	0.29	0.8	1.73	6.88	0.32	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4896	4896	T	C	MI.13659	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	427	143	Y	H	Tac/Cac	-4.81	0	0	possibly_damaging	0.9	neutral	0.27	neutral	4.57	neutral	-2.95	deleterious	-3.92	medium_impact	2.85	0.9	neutral	0.23	damaging	3.51	23.10	deleterious	0.12	0.4	0.83	disease	0.63	disease	0.64	disease	0.67	disease	3	0.92	neutral	0.19	neutral	0	NA	0.79	deleterious	-1.67	low_impact	-0.03	medium_impact	1.26	medium_impact	0.33	0.8	1.73	6.88	0.43	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9167	9167	T	A	MI.1366	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	641	214	F	Y	tTc/tAc	5.68	1	0	probably_damaging	0.98	deleterious	0	neutral	2.26	deleterious	-5.35	deleterious	-2.65	high_impact	3.51	0.56	damaging	0.55	neutral	4.26	23.90	deleterious	0.15	0.65	NA	NA	0.85	disease	0.68	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.36	low_impact	-1.4	low_impact	1.91	medium_impact	0.48	0.9	49.56	8.9	0.52	P	0.89	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4897	4897	A	G	MI.13660	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	428	143	Y	C	tAc/tGc	-0.66	0	0	benign	0.04	neutral	0.19	neutral	4.6	deleterious	-3.22	deleterious	-6.28	medium_impact	2.5	0.94	neutral	0.67	neutral	3.38	22.90	deleterious	0.05	0.35	0.73	disease	0.75	disease	0.58	disease	0.59	disease	2	0.8	neutral	0.58	deleterious	-3	neutral	0.27	neutral	0.47	medium_impact	-0.14	medium_impact	0.96	medium_impact	0.18	0.8	1.73	6.88	0.41	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4897	4897	A	C	MI.13661	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	428	143	Y	S	tAc/tCc	-0.66	0	0	possibly_damaging	0.53	neutral	0.34	neutral	4.62	neutral	-2.03	deleterious	-6.6	low_impact	1.27	0.89	neutral	0.18	damaging	3.61	23.20	deleterious	0.06	0.35	0.58	disease	0.68	disease	0.61	disease	0.59	disease	2	0.65	neutral	0.41	neutral	-3	neutral	0.64	deleterious	-0.84	medium_impact	0.05	medium_impact	-0.08	medium_impact	0.41	0.8	1.73	6.88	0.37	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4897	4897	A	T	MI.13662	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	428	143	Y	F	tAc/tTc	-0.66	0	0	benign	0.02	neutral	0.44	neutral	4.64	neutral	0.84	deleterious	-2.78	low_impact	1.12	0.9	neutral	0.78	neutral	2.18	17.35	deleterious	0.24	0.45	0.45	neutral	0.3	neutral	0.41	neutral	0.45	neutral	1	0.54	neutral	0.71	deleterious	-6	neutral	0.19	neutral	0.75	medium_impact	0.15	medium_impact	-0.2	medium_impact	0.64	0.8	1.73	6.88	0.4	N	0.33	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4899	4899	C	G	MI.13663	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	430	144	Q	E	Caa/Gaa	-3.88	0	0	probably_damaging	0.99	neutral	0.27	neutral	4.66	neutral	0.21	deleterious	-2.77	medium_impact	2.5	0.86	neutral	0.11	damaging	2.99	22.20	deleterious	0.31	0.45	0.72	disease	0.7	disease	0.76	disease	0.71	disease	4	0.99	deleterious	0.14	neutral	1	deleterious	0.84	deleterious	-2.62	low_impact	-0.03	medium_impact	0.96	medium_impact	0.34	0.8	0.86	6.95	0.29	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4899	4899	C	A	MI.13664	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	430	144	Q	K	Caa/Aaa	-3.88	0	0	probably_damaging	0.99	neutral	0.29	neutral	4.68	neutral	0.49	deleterious	-3.59	medium_impact	2.84	0.83	neutral	0.12	damaging	4.01	23.60	deleterious	0.2	0.45	0.34	neutral	0.76	disease	0.76	disease	0.7	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-2.62	low_impact	-0.01	medium_impact	1.25	medium_impact	0.26	0.8	0.86	6.95	0.31	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4900	4900	A	G	MI.13665	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	431	144	Q	R	cAa/cGa	0.03	0	0	probably_damaging	0.99	neutral	0.35	neutral	5.04	neutral	2.7	deleterious	-3.6	medium_impact	3.04	0.83	neutral	0.12	damaging	3.45	23.00	deleterious	0.23	0.45	0.79	disease	0.76	disease	0.79	disease	0.71	disease	4	0.99	deleterious	0.18	neutral	1	deleterious	0.85	deleterious	-2.62	low_impact	0.06	medium_impact	1.42	medium_impact	0.13	0.8	0.86	6.95	0.34	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4900	4900	A	T	MI.13666	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	431	144	Q	L	cAa/cTa	0.03	0	0	probably_damaging	1	neutral	0.67	neutral	4.6	neutral	-1.17	deleterious	-5.99	low_impact	0.96	0.9	neutral	0.55	neutral	3.70	23.30	deleterious	0.09	0.4	0.68	disease	0.54	disease	0.43	neutral	0.27	neutral	5	1	deleterious	0.34	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	0.38	medium_impact	-0.34	medium_impact	0.11	0.8	0.86	6.95	0.29	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4900	4900	A	C	MI.13667	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	431	144	Q	P	cAa/cCa	0.03	0	0	probably_damaging	1	neutral	0.2	neutral	4.58	neutral	-1.94	deleterious	-5.42	medium_impact	2.84	0.71	neutral	0.11	damaging	3.30	22.90	deleterious	0.03	0.35	0.92	disease	0.88	disease	0.8	disease	0.68	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.91	deleterious	-3.54	low_impact	-0.13	medium_impact	1.25	medium_impact	0.24	0.8	0.86	6.95	0.31	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4901	4901	A	T	MI.13668	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	432	144	Q	H	caA/caT	2.79	0.31	0	probably_damaging	1	neutral	0.54	neutral	4.61	neutral	-0.76	deleterious	-4.57	medium_impact	2.84	0.87	neutral	0.3	neutral	3.48	23.10	deleterious	0.22	0.45	0.9	disease	0.67	disease	0.68	disease	0.69	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	0.25	medium_impact	1.25	medium_impact	0.44	0.8	0.86	6.95	0.32	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4901	4901	A	C	MI.13669	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	432	144	Q	H	caA/caC	2.79	0.31	0	probably_damaging	1	neutral	0.54	neutral	4.61	neutral	-0.76	deleterious	-4.57	medium_impact	2.84	0.87	neutral	0.3	neutral	3.31	22.90	deleterious	0.22	0.45	0.9	disease	0.67	disease	0.68	disease	0.69	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	0.25	medium_impact	1.25	medium_impact	0.44	0.8	0.86	6.95	0.32	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9167	9167	T	G	MI.1367	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	641	214	F	C	tTc/tGc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.16	deleterious	-10.17	deleterious	-7.05	high_impact	4.55	0.56	damaging	0.55	neutral	4.16	23.80	deleterious	0.14	0.65	NA	NA	0.88	disease	0.69	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.8	high_impact	0.20	0.9	49.56	8.9	0.43	N	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4902	4902	A	C	MI.13670	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	433	145	I	L	Atc/Ctc	2.1	0.31	0	benign	0.09	neutral	1	neutral	4.89	neutral	1.51	neutral	-1.5	low_impact	1.04	0.84	neutral	0.92	neutral	0.44	6.96	deleterious	0.31	0.45	0.5	neutral	0.46	neutral	0.28	neutral	0.19	neutral	6	0.09	neutral	0.96	deleterious	-6	neutral	0.26	neutral	0.12	medium_impact	1.87	high_impact	-0.27	medium_impact	0.71	0.85	3.17	7.79	0.29	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4902	4902	A	T	MI.13671	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	433	145	I	F	Atc/Ttc	2.1	0.31	0	possibly_damaging	0.69	neutral	0.79	neutral	4.66	neutral	0.13	deleterious	-3.49	low_impact	1.62	0.92	neutral	0.74	neutral	1.84	15.23	deleterious	0.19	0.45	0.4	neutral	0.68	disease	0.64	disease	0.68	disease	4	0.62	neutral	0.55	deleterious	-3	neutral	0.65	deleterious	-1.12	low_impact	0.53	medium_impact	0.22	medium_impact	0.70	0.85	3.17	7.79	0.36	N	0.33	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4902	4902	A	G	MI.13672	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	433	145	I	V	Atc/Gtc	2.1	0.31	0	benign	0.02	neutral	0.5	neutral	4.71	neutral	0.56	neutral	-0.73	low_impact	1.75	0.93	neutral	0.71	neutral	0.94	10.29	neutral	0.43	0.55	0.58	disease	0.25	neutral	0.32	neutral	0.55	disease	1	0.47	neutral	0.74	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	0.21	medium_impact	0.33	medium_impact	0.52	0.8	3.17	7.79	0.32	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4903	4903	T	C	MI.13673	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	434	145	I	T	aTc/aCc	0.49	0.06	0	possibly_damaging	0.58	neutral	0.49	neutral	4.56	neutral	-1.15	deleterious	-3.9	neutral_impact	0.64	0.82	neutral	0.95	neutral	0.49	7.39	deleterious	0.08	0.35	0.35	neutral	0.11	neutral	0.33	neutral	0.32	neutral	4	0.57	neutral	0.46	neutral	-3	neutral	0.55	deleterious	-0.93	medium_impact	0.2	medium_impact	-0.61	medium_impact	0.28	0.8	3.17	7.79	0.43	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4903	4903	T	G	MI.13674	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	434	145	I	S	aTc/aGc	0.49	0.06	0	possibly_damaging	0.73	neutral	0.78	neutral	4.55	neutral	-1.42	deleterious	-5.05	low_impact	1.32	0.86	neutral	0.56	neutral	2.58	19.97	deleterious	0.03	0.35	0.66	disease	0.71	disease	0.63	disease	0.59	disease	2	0.67	neutral	0.53	deleterious	-3	neutral	0.74	deleterious	-1.19	low_impact	0.51	medium_impact	-0.03	medium_impact	0.14	0.8	3.17	7.79	0.21	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4903	4903	T	A	MI.13675	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	434	145	I	N	aTc/aAc	0.49	0.06	0	possibly_damaging	0.89	neutral	0.26	neutral	4.51	deleterious	-3.14	deleterious	-6.03	low_impact	1.59	0.9	neutral	0.63	neutral	4.29	24.00	deleterious	0.06	0.35	0.86	disease	0.71	disease	0.64	disease	0.67	disease	3	0.92	neutral	0.19	neutral	-3	neutral	0.78	deleterious	-1.63	low_impact	-0.04	medium_impact	0.19	medium_impact	0.13	0.8	3.17	7.79	0.45	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4904	4904	C	G	MI.13676	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	435	145	I	M	atC/atG	0.95	0.04	0	benign	0.11	neutral	0.35	neutral	4.64	neutral	-0.06	neutral	-2.19	low_impact	1.41	0.94	neutral	0.94	neutral	0.30	5.68	deleterious	0.28	0.45	0.75	disease	0.35	neutral	0.29	neutral	0.64	disease	3	0.6	neutral	0.62	deleterious	-6	neutral	0.31	neutral	0.03	medium_impact	0.06	medium_impact	0.04	medium_impact	0.63	0.8	3.17	7.79	0.42	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4904	4904	C	A	MI.13677	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	435	145	I	M	atC/atA	0.95	0.04	0	benign	0.11	neutral	0.35	neutral	4.64	neutral	-0.06	neutral	-2.19	low_impact	1.41	0.94	neutral	0.94	neutral	0.70	8.84	deleterious	0.28	0.45	0.75	disease	0.35	neutral	0.29	neutral	0.64	disease	3	0.6	neutral	0.62	deleterious	-6	neutral	0.31	neutral	0.03	medium_impact	0.06	medium_impact	0.04	medium_impact	0.63	0.8	3.17	7.79	0.43	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4905	4905	T	C	MI.13678	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	436	146	S	P	Tct/Cct	-8.49	0	0	possibly_damaging	0.64	neutral	0.21	neutral	4.49	deleterious	-3.42	deleterious	-2.77	low_impact	1.35	0.75	neutral	0.35	neutral	2.59	20.10	deleterious	0.07	0.35	0.42	neutral	0.85	disease	0.64	disease	0.71	disease	4	0.81	neutral	0.29	neutral	-3	neutral	0.67	deleterious	-1.03	low_impact	-0.11	medium_impact	-0.01	medium_impact	0.31	0.8	6.34	7.89	0.31	N	0.78	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4905	4905	T	G	MI.13679	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	436	146	S	A	Tct/Gct	-8.49	0	0	benign	0.12	neutral	0.52	neutral	4.55	neutral	-1.23	neutral	-0.64	low_impact	1.32	0.88	neutral	0.98	neutral	0.13	3.93	deleterious	0.29	0.45	0.42	neutral	0.23	neutral	0.28	neutral	0.43	neutral	1	0.39	neutral	0.7	deleterious	-6	neutral	0.26	neutral	-0.01	medium_impact	0.23	medium_impact	-0.03	medium_impact	0.42	0.8	6.34	7.89	0.4	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9168	9168	C	A	MI.1368	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	642	214	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.98	deleterious	0.03	neutral	2.24	deleterious	-6.92	deleterious	-5.2	high_impact	3.58	0.54	damaging	0.64	neutral	4.69	24.60	deleterious	0.19	0.65	NA	NA	0.87	disease	0.65	disease	0.67	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.85	deleterious	-2.36	low_impact	-0.56	medium_impact	1.97	medium_impact	0.48	0.9	49.56	8.9	0.5	P	0.89	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4905	4905	T	A	MI.13680	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	436	146	S	T	Tct/Act	-8.49	0	0	benign	0.3	neutral	0.4	neutral	4.6	neutral	-0.43	neutral	-0.88	low_impact	1.17	0.88	neutral	0.92	neutral	0.56	7.85	deleterious	0.3	0.45	0.6	disease	0.45	neutral	0.29	neutral	0.6	disease	2	0.52	neutral	0.55	deleterious	-6	neutral	0.44	deleterious	-0.46	medium_impact	0.11	medium_impact	-0.16	medium_impact	0.52	0.8	6.34	7.89	0.39	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4906	4906	C	T	MI.13681	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	437	146	S	F	tCt/tTt	-3.88	0	0	benign	0	neutral	0.7	neutral	4.59	neutral	-0.61	neutral	-1.88	low_impact	1.21	0.94	neutral	0.92	neutral	0.52	7.58	deleterious	0.09	0.35	0.55	disease	0.79	disease	0.41	neutral	0.54	disease	1	0.29	neutral	0.85	deleterious	-6	neutral	0.20	neutral	1.95	medium_impact	0.41	medium_impact	-0.13	medium_impact	0.13	0.8	6.34	7.89	0.22	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4906	4906	C	G	MI.13682	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	437	146	S	C	tCt/tGt	-3.88	0	0	possibly_damaging	0.85	neutral	0.18	neutral	4.51	neutral	-2.32	neutral	-2.36	medium_impact	2.06	0.79	neutral	0.38	neutral	2.36	18.53	deleterious	0.09	0.35	0.83	disease	0.72	disease	0.39	neutral	0.56	disease	1	0.92	neutral	0.17	neutral	0	NA	0.72	deleterious	-1.49	low_impact	-0.16	medium_impact	0.59	medium_impact	0.24	0.8	6.34	7.89	0.3	N	0.56	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4906	4906	C	A	MI.13683	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	437	146	S	Y	tCt/tAt	-3.88	0	0	benign	0	neutral	1	neutral	4.56	neutral	-1.1	neutral	-1.3	low_impact	0.91	0.91	neutral	0.97	neutral	-0.23	0.97	neutral	0.07	0.35	0.57	disease	0.71	disease	0.38	neutral	0.53	disease	1	0	neutral	1	deleterious	-6	neutral	0.20	neutral	1.95	medium_impact	1.87	high_impact	-0.38	medium_impact	0.22	0.8	6.34	7.89	0.25	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4908	4908	C	T	MI.13684	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	439	147	P	S	Ccc/Tcc	-4.81	0	0	benign	0	neutral	0.49	neutral	4.61	neutral	-2.7	deleterious	-4.2	neutral_impact	0.6	0.92	neutral	0.99	neutral	0.67	8.61	deleterious	0.23	0.45	0.46	neutral	0.45	neutral	0.29	neutral	0.46	neutral	1	0.5	neutral	0.75	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	0.2	medium_impact	-0.64	medium_impact	0.04	0.8	2.88	9.03	0.42	N	0.02	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4908	4908	C	G	MI.13685	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	439	147	P	A	Ccc/Gcc	-4.81	0	0	benign	0.05	neutral	0.57	neutral	4.6	neutral	-2.66	deleterious	-4.9	low_impact	1.75	0.9	neutral	0.71	neutral	1.12	11.32	neutral	0.24	0.45	0.44	neutral	0.34	neutral	0.46	neutral	0.47	neutral	1	0.37	neutral	0.76	deleterious	-6	neutral	0.21	neutral	0.37	medium_impact	0.28	medium_impact	0.33	medium_impact	0.36	0.8	2.88	9.03	0.35	N	0.52	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4908	4908	C	A	MI.13686	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	439	147	P	T	Ccc/Acc	-4.81	0	0	benign	0.01	neutral	0.44	neutral	4.58	deleterious	-3.09	deleterious	-4.49	low_impact	1.52	0.94	neutral	0.85	neutral	0.75	9.12	deleterious	0.23	0.45	0.53	disease	0.44	neutral	0.32	neutral	0.36	neutral	3	0.55	neutral	0.72	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.15	medium_impact	0.14	medium_impact	0.36	0.8	2.88	9.03	0.38	N	0.59	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4909	4909	C	G	MI.13687	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	440	147	P	R	cCc/cGc	-5.27	0	0	possibly_damaging	0.44	neutral	0.39	neutral	4.57	deleterious	-3.53	deleterious	-5.42	medium_impact	3	0.87	neutral	0.35	neutral	1.87	15.38	deleterious	0.11	0.4	0.76	disease	0.73	disease	0.59	disease	0.68	disease	4	0.56	neutral	0.48	deleterious	0	NA	0.57	deleterious	-0.7	medium_impact	0.1	medium_impact	1.38	medium_impact	0.27	0.8	2.88	9.03	0.33	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4909	4909	C	A	MI.13688	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	440	147	P	H	cCc/cAc	-5.27	0	0	possibly_damaging	0.69	neutral	0.55	neutral	4.54	deleterious	-4.26	deleterious	-5.07	low_impact	0.96	0.84	neutral	0.95	neutral	2.59	20.10	deleterious	0.13	0.4	0.81	disease	0.4	neutral	0.4	neutral	0.65	disease	3	0.65	neutral	0.43	neutral	-3	neutral	0.67	deleterious	-1.12	low_impact	0.26	medium_impact	-0.34	medium_impact	0.18	0.8	2.88	9.03	0.32	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4909	4909	C	T	MI.13689	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	440	147	P	L	cCc/cTc	-5.27	0	0	benign	0.2	neutral	0.69	neutral	4.66	deleterious	-3.66	deleterious	-6.68	low_impact	1.31	0.9	neutral	0.58	neutral	2.52	19.59	deleterious	0.15	0.4	0.71	disease	0.67	disease	0.55	disease	0.64	disease	3	0.2	neutral	0.75	deleterious	-6	neutral	0.36	neutral	-0.25	medium_impact	0.4	medium_impact	-0.04	medium_impact	0.57	0.8	2.88	9.03	0.26	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9168	9168	C	G	MI.1369	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	642	214	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.98	deleterious	0.03	neutral	2.24	deleterious	-6.92	deleterious	-5.2	high_impact	3.58	0.54	damaging	0.64	neutral	4.40	24.10	deleterious	0.19	0.65	NA	NA	0.87	disease	0.65	disease	0.67	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.85	deleterious	-2.36	low_impact	-0.56	medium_impact	1.97	medium_impact	0.48	0.9	49.56	8.9	0.49	N	0.89	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4911	4911	T	A	MI.13690	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	442	148	S	T	Tca/Aca	-2.73	0	0	benign	0.04	neutral	0.44	neutral	4.64	neutral	-0.18	neutral	-2.13	low_impact	1.5	0.91	neutral	0.96	neutral	0.41	6.68	deleterious	0.42	0.55	0.44	neutral	0.32	neutral	0.5	neutral	0.45	neutral	1	0.52	neutral	0.7	deleterious	-6	neutral	0.16	neutral	0.47	medium_impact	0.15	medium_impact	0.12	medium_impact	0.43	0.8	1.73	7.99	0.37	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4911	4911	T	C	MI.13691	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	442	148	S	P	Tca/Cca	-2.73	0	0	benign	0.03	neutral	0.22	neutral	4.63	neutral	-0.28	deleterious	-4.07	low_impact	1.88	0.95	neutral	0.61	neutral	2.20	17.50	deleterious	0.12	0.4	0.91	disease	0.85	disease	0.76	disease	0.7	disease	4	0.77	neutral	0.6	deleterious	-6	neutral	0.32	neutral	0.59	medium_impact	-0.1	medium_impact	0.44	medium_impact	0.12	0.8	1.73	7.99	0.39	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4911	4911	T	G	MI.13692	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	442	148	S	A	Tca/Gca	-2.73	0	0	benign	0.26	neutral	0.56	neutral	4.65	neutral	0.17	neutral	-2.24	medium_impact	2.04	0.92	neutral	0.85	neutral	0.68	8.68	deleterious	0.42	0.55	0.7	disease	0.37	neutral	0.65	disease	0.67	disease	3	0.33	neutral	0.65	deleterious	-3	neutral	0.42	neutral	-0.38	medium_impact	0.27	medium_impact	0.57	medium_impact	0.15	0.8	1.73	7.99	0.32	N	0.30	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4912	4912	C	G	MI.13693	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	443	148	S	W	tCa/tGa	-0.66	0	0	probably_damaging	0.92	neutral	0.19	neutral	4.59	neutral	-2.82	deleterious	-5.46	medium_impact	3.05	0.87	neutral	0.47	neutral	4.11	23.70	deleterious	0.09	0.4	0.94	disease	0.85	disease	0.76	disease	0.72	disease	4	0.95	neutral	0.14	neutral	1	deleterious	0.81	deleterious	-1.77	low_impact	-0.14	medium_impact	1.42	medium_impact	0.14	0.8	1.73	7.99	0.39	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4912	4912	C	T	MI.13694	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	443	148	S	L	tCa/tTa	-0.66	0	0	benign	0.1	neutral	0.69	neutral	5	neutral	2.84	deleterious	-4.4	low_impact	1.4	0.87	neutral	0.95	neutral	1.29	12.21	neutral	0.21	0.45	0.43	neutral	0.75	disease	0.64	disease	0.42	neutral	2	0.2	neutral	0.8	deleterious	-6	neutral	0.29	neutral	0.08	medium_impact	0.4	medium_impact	0.03	medium_impact	0.36	0.8	1.73	7.99	0.29	N	0.48	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4914	4914	C	G	MI.13695	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	445	149	L	V	Cta/Gta	-8.03	0	0	benign	0	neutral	0.65	neutral	4.53	neutral	-1.47	neutral	0.21	low_impact	1.51	0.88	neutral	0.85	neutral	0.21	4.73	deleterious	0.39	0.5	0.62	disease	0.34	neutral	0.45	neutral	0.6	disease	2	0.35	neutral	0.83	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	0.36	medium_impact	0.13	medium_impact	0.31	0.8	3.46	7.65	0.33	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4914	4914	C	A	MI.13696	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	445	149	L	M	Cta/Ata	-8.03	0	0	benign	0.01	neutral	0.38	neutral	4.52	neutral	-2.85	neutral	-0.3	neutral_impact	0.79	0.87	neutral	0.88	neutral	0.40	6.61	deleterious	0.3	0.45	0.78	disease	0.26	neutral	0.4	neutral	0.58	disease	2	0.61	neutral	0.69	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	0.09	medium_impact	-0.48	medium_impact	0.55	0.8	3.46	7.65	0.42	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4915	4915	T	C	MI.13697	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	446	149	L	P	cTa/cCa	-1.58	0	0	benign	0.24	neutral	0.23	neutral	4.46	deleterious	-5.02	deleterious	-4.71	medium_impact	2.39	0.76	neutral	0.36	neutral	1.95	15.91	deleterious	0.05	0.35	0.86	disease	0.78	disease	0.78	disease	0.83	disease	7	0.72	neutral	0.5	deleterious	-3	neutral	0.35	neutral	-0.34	medium_impact	-0.08	medium_impact	0.87	medium_impact	0.16	0.8	3.46	7.65	0.33	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4915	4915	T	G	MI.13698	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	446	149	L	R	cTa/cGa	-1.58	0	0	benign	0.19	neutral	0.33	neutral	4.45	deleterious	-3.85	deleterious	-4.43	medium_impact	3.08	0.79	neutral	0.4	neutral	2.16	17.24	deleterious	0.06	0.35	0.77	disease	0.77	disease	0.78	disease	0.78	disease	6	0.61	neutral	0.57	deleterious	-3	neutral	0.31	neutral	-0.22	medium_impact	0.04	medium_impact	1.45	medium_impact	0.11	0.8	3.46	7.65	0.36	N	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4915	4915	T	A	MI.13699	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	446	149	L	Q	cTa/cAa	-1.58	0	0	benign	0.24	neutral	0.3	neutral	4.45	deleterious	-3.84	deleterious	-4.24	medium_impact	2.39	0.82	neutral	0.48	neutral	2.18	17.38	deleterious	0.11	0.4	0.67	disease	0.66	disease	0.66	disease	0.68	disease	4	0.64	neutral	0.53	deleterious	-3	neutral	0.26	neutral	-0.34	medium_impact	0	medium_impact	0.87	medium_impact	0.13	0.8	3.46	7.65	0.31	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8591	8591	T	C	MI.137	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	65	22	L	P	cTg/cCg	-5.89	0	0	benign	0	neutral	0.06	neutral	4.11	deleterious	-4.23	deleterious	-3.66	low_impact	1.92	0.94	neutral	0.9	neutral	0.56	7.86	deleterious	0.16	0.65	0.76	disease	0.73	disease	0.57	disease	0.59	disease	2	0.94	neutral	0.53	deleterious	-6	neutral	0.30	neutral	2.09	high_impact	-0.38	medium_impact	0.55	medium_impact	0.60	0.9	25.22	20.33	0.37	N	0.13	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9169	9169	A	G	MI.1370	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	643	215	T	A	Aca/Gca	-3.34	0	0	probably_damaging	0.99	neutral	0.39	neutral	4.33	neutral	-0.94	deleterious	-2.7	neutral_impact	0.45	0.88	neutral	0.5	neutral	2.47	19.26	deleterious	0.32	0.65	NA	NA	0.44	neutral	0.3	neutral	0.2	neutral	6	0.99	deleterious	0.2	neutral	-2	neutral	0.75	deleterious	-2.65	low_impact	0.18	medium_impact	-0.71	medium_impact	0.48	0.9	46.9	8.38	0.3	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4917	4917	A	T	MI.13700	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	448	150	N	Y	Aac/Tac	-8.95	0	0.1	probably_damaging	0.97	neutral	1	neutral	4.54	neutral	-2.62	deleterious	-7.36	medium_impact	2.38	0.87	neutral	0.44	neutral	3.59	23.20	deleterious	0.15	0.4	0.84	disease	0.85	disease	0.7	disease	0.66	disease	3	0.97	neutral	0.52	deleterious	1	deleterious	0.82	deleterious	-2.18	low_impact	1.87	high_impact	0.86	medium_impact	0.17	0.8	NA	NA	0.24	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4917	4917	A	G	MI.13701	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	448	150	N	D	Aac/Gac	-8.95	0	0.1	benign	0.06	neutral	0.22	neutral	4.6	neutral	-0.42	deleterious	-3.86	low_impact	1.4	0.4	damaging	0.78	neutral	0.70	8.80	deleterious	0.4	0.5	0.66	disease	0.67	disease	0.49	neutral	0.21	neutral	6	0.76	neutral	0.58	deleterious	-6	neutral	0.27	neutral	0.3	medium_impact	-0.1	medium_impact	0.03	medium_impact	0.32	0.8	NA	NA	0.71	P	0.35	polymorphism	1	0.06	rs28357980	Uncertain_significance	Leber's_optic_atrophy	24755	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	A4917G	LHON / Insulin Resistance / AMD / NRTI-PN	+	-	Reported, haplogroup T marker	27	N	P	N,P	neutral
chrM	4917	4917	A	C	MI.13702	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	448	150	N	H	Aac/Cac	-8.95	0	0.1	probably_damaging	0.97	neutral	0.54	neutral	4.58	neutral	-1.28	deleterious	-4.55	low_impact	1.69	0.85	neutral	0.52	neutral	2.94	22.00	deleterious	0.32	0.5	0.65	disease	0.78	disease	0.52	disease	0.22	neutral	6	0.96	neutral	0.29	neutral	-2	neutral	0.78	deleterious	-2.18	low_impact	0.25	medium_impact	0.28	medium_impact	0.13	0.8	NA	NA	0.2	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4918	4918	A	T	MI.13703	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	449	150	N	I	aAc/aTc	2.1	0.41	0	probably_damaging	0.93	neutral	0.41	neutral	4.58	neutral	-2.68	deleterious	-8.23	medium_impact	2.56	0.84	neutral	0.54	neutral	3.68	23.30	deleterious	0.17	0.45	0.64	disease	0.9	disease	0.65	disease	0.69	disease	4	0.93	neutral	0.24	neutral	1	deleterious	0.78	deleterious	-1.83	low_impact	0.12	medium_impact	1.01	medium_impact	0.13	0.8	NA	NA	0.34	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4918	4918	A	G	MI.13704	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	449	150	N	S	aAc/aGc	2.1	0.41	0	possibly_damaging	0.56	neutral	0.43	neutral	4.7	neutral	0.16	deleterious	-4.35	low_impact	1.54	0.93	neutral	0.65	neutral	1.21	11.78	neutral	0.47	0.55	0.52	disease	0.64	disease	0.45	neutral	0.18	neutral	6	0.59	neutral	0.44	neutral	-3	neutral	0.64	deleterious	-0.89	medium_impact	0.14	medium_impact	0.15	medium_impact	0.21	0.8	NA	NA	0.38	N	0.79	polymorphism	1	0.06	rs879058895	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4918	4918	A	C	MI.13705	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	449	150	N	T	aAc/aCc	2.1	0.41	0	possibly_damaging	0.81	neutral	0.4	neutral	4.59	neutral	-0.77	deleterious	-5.38	medium_impact	2.12	0.83	neutral	0.57	neutral	2.92	22.00	deleterious	0.31	0.45	0.52	disease	0.74	disease	0.65	disease	0.42	neutral	2	0.81	neutral	0.3	neutral	0	NA	0.71	deleterious	-1.37	low_impact	0.11	medium_impact	0.64	medium_impact	0.21	0.8	NA	NA	0.32	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4919	4919	C	G	MI.13706	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	450	150	N	K	aaC/aaG	3.48	0.5	0	possibly_damaging	0.76	neutral	0.3	neutral	4.64	neutral	-0.83	deleterious	-5.4	low_impact	1.8	0.84	neutral	0.39	neutral	2.34	18.44	deleterious	0.31	0.45	0.51	disease	0.83	disease	0.68	disease	0.68	disease	4	0.81	neutral	0.27	neutral	-3	neutral	0.74	deleterious	-1.26	low_impact	0	medium_impact	0.37	medium_impact	0.29	0.8	NA	NA	0.36	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4919	4919	C	A	MI.13707	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	450	150	N	K	aaC/aaA	3.48	0.5	0	possibly_damaging	0.76	neutral	0.3	neutral	4.64	neutral	-0.83	deleterious	-5.4	low_impact	1.8	0.84	neutral	0.39	neutral	2.85	21.60	deleterious	0.31	0.45	0.51	disease	0.83	disease	0.68	disease	0.68	disease	4	0.81	neutral	0.27	neutral	-3	neutral	0.74	deleterious	-1.26	low_impact	0	medium_impact	0.37	medium_impact	0.29	0.8	NA	NA	0.36	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4920	4920	G	T	MI.13708	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	451	151	V	L	Gta/Tta	-0.89	0	0	benign	0	neutral	0.83	neutral	4.72	neutral	1.23	neutral	0.11	neutral_impact	-1.43	0.91	neutral	0.94	neutral	-0.63	0.11	neutral	0.36	0.5	0.45	neutral	0.27	neutral	0.3	neutral	0.44	neutral	1	0.16	neutral	0.92	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.59	medium_impact	-2.35	low_impact	0.49	0.8	22.19	10.8	0.32	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4920	4920	G	A	MI.13709	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	451	151	V	M	Gta/Ata	-0.89	0	0	benign	0.02	neutral	0.27	neutral	4.63	neutral	-0.34	neutral	-0.01	neutral_impact	-1.05	0.93	neutral	0.93	neutral	0.22	4.91	deleterious	0.29	0.45	0.77	disease	0.22	neutral	0.21	neutral	0.53	disease	1	0.72	neutral	0.63	deleterious	-6	neutral	0.21	neutral	0.75	medium_impact	-0.03	medium_impact	-2.03	low_impact	0.52	0.8	22.19	10.8	0.44	N	0.17	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9169	9169	A	T	MI.1371	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	643	215	T	S	Aca/Tca	-3.34	0	0	probably_damaging	0.99	neutral	0.94	neutral	4.37	neutral	-2.36	deleterious	-2.78	low_impact	0.8	0.83	neutral	0.11	damaging	3.37	22.90	deleterious	0.25	0.65	NA	NA	0.48	neutral	0.28	neutral	0.31	neutral	4	0.99	deleterious	0.48	deleterious	-2	neutral	0.77	deleterious	-2.65	low_impact	0.97	medium_impact	-0.41	medium_impact	0.56	0.9	46.9	8.38	0.16	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4920	4920	G	C	MI.13710	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	451	151	V	L	Gta/Cta	-0.89	0	0	benign	0	neutral	0.83	neutral	4.72	neutral	1.23	neutral	0.11	neutral_impact	-1.43	0.91	neutral	0.94	neutral	-0.75	0.06	neutral	0.36	0.5	0.45	neutral	0.27	neutral	0.3	neutral	0.44	neutral	1	0.16	neutral	0.92	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.59	medium_impact	-2.35	low_impact	0.49	0.8	22.19	10.8	0.32	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4921	4921	T	C	MI.13711	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	452	151	V	A	gTa/gCa	-5.04	0	0	benign	0.09	neutral	0.53	neutral	4.68	neutral	0.62	neutral	-0.38	neutral_impact	-0.18	0.89	neutral	0.8	neutral	-0.24	0.89	neutral	0.23	0.45	0.59	disease	0.2	neutral	0.37	neutral	0.48	neutral	0	0.39	neutral	0.72	deleterious	-6	neutral	0.24	neutral	0.12	medium_impact	0.24	medium_impact	-1.3	low_impact	0.15	0.8	22.19	10.8	0.33	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4921	4921	T	A	MI.13712	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	452	151	V	E	gTa/gAa	-5.04	0	0	benign	0.27	neutral	0.27	neutral	4.66	neutral	0.34	neutral	-1.17	neutral_impact	-0.06	0.88	neutral	0.58	neutral	1.35	12.52	neutral	0.05	0.35	0.91	disease	0.69	disease	0.52	disease	0.63	disease	3	0.67	neutral	0.5	deleterious	-6	neutral	0.57	deleterious	-0.4	medium_impact	-0.03	medium_impact	-1.2	low_impact	0.14	0.8	22.19	10.8	0.32	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4921	4921	T	G	MI.13713	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	452	151	V	G	gTa/gGa	-5.04	0	0	benign	0.21	neutral	0.35	neutral	4.61	neutral	-0.96	neutral	-2.16	neutral_impact	-0.22	0.86	neutral	0.49	neutral	0.39	6.52	deleterious	0.09	0.35	0.71	disease	0.4	neutral	0.4	neutral	0.65	disease	3	0.58	neutral	0.57	deleterious	-6	neutral	0.44	deleterious	-0.27	medium_impact	0.06	medium_impact	-1.33	low_impact	0.23	0.8	22.19	10.8	0.3	N	0.44	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4923	4923	A	G	MI.13714	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	454	152	S	G	Agc/Ggc	-7.34	0	0	benign	0.14	neutral	0.38	neutral	4.55	neutral	-2	neutral	-1.52	neutral_impact	0.74	0.94	neutral	0.62	neutral	1.60	13.83	neutral	0.26	0.45	0.5	neutral	0.19	neutral	0.47	neutral	0.25	neutral	5	0.55	neutral	0.62	deleterious	-6	neutral	0.24	neutral	-0.08	medium_impact	0.09	medium_impact	-0.52	medium_impact	0.49	0.8	10.66	8.21	0.37	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4923	4923	A	T	MI.13715	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	454	152	S	C	Agc/Tgc	-7.34	0	0	benign	0.02	neutral	0.18	neutral	4.53	deleterious	-3.55	deleterious	-3.25	low_impact	1.29	0.88	neutral	0.74	neutral	3.24	22.80	deleterious	0.13	0.4	0.96	disease	0.4	neutral	0.48	neutral	0.66	disease	3	0.81	neutral	0.58	deleterious	-6	neutral	0.22	neutral	0.75	medium_impact	-0.16	medium_impact	-0.06	medium_impact	0.28	0.8	10.66	8.21	0.4	N	0.42	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4923	4923	A	C	MI.13716	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	454	152	S	R	Agc/Cgc	-7.34	0	0	benign	0.39	neutral	0.35	neutral	4.57	neutral	-1.31	neutral	-1.25	low_impact	1.84	0.87	neutral	0.51	neutral	1.97	16.00	deleterious	0.09	0.35	0.81	disease	0.5	disease	0.57	disease	0.66	disease	3	0.59	neutral	0.48	deleterious	-6	neutral	0.52	deleterious	-0.62	medium_impact	0.06	medium_impact	0.4	medium_impact	0.39	0.8	10.66	8.21	0.34	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4924	4924	G	T	MI.13717	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	455	152	S	I	aGc/aTc	-3.88	0	0.01	benign	0.39	neutral	0.5	neutral	4.63	neutral	-0.2	deleterious	-3.24	neutral_impact	0.28	0.88	neutral	0.66	neutral	3.58	23.20	deleterious	0.12	0.4	0.88	disease	0.43	neutral	0.48	neutral	0.66	disease	3	0.43	neutral	0.56	deleterious	-6	neutral	0.52	deleterious	-0.62	medium_impact	0.21	medium_impact	-0.91	medium_impact	0.29	0.8	10.66	8.21	0.32	N	0.33	polymorphism	1	0.05	rs386828956	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4924	4924	G	A	MI.13718	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	455	152	S	N	aGc/aAc	-3.88	0	0.01	benign	0	neutral	0.37	neutral	4.68	neutral	0.38	neutral	2.47	neutral_impact	-1.2	0.93	neutral	0.99	neutral	-1.04	0.01	neutral	0.45	0.55	0.68	disease	0.12	neutral	0.32	neutral	0.35	neutral	3	0.63	neutral	0.69	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.08	medium_impact	-2.15	low_impact	0.32	0.8	10.66	8.21	0.34	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4924	4924	G	C	MI.13719	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	455	152	S	T	aGc/aCc	-3.88	0	0.01	benign	0.01	neutral	0.46	neutral	4.62	neutral	-0.35	neutral	-0.29	neutral_impact	-1.08	0.94	neutral	0.96	neutral	-0.17	1.28	neutral	0.31	0.45	0.52	disease	0.03	neutral	0.26	neutral	0.16	neutral	7	0.53	neutral	0.73	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.17	medium_impact	-2.05	low_impact	0.42	0.8	10.66	8.21	0.44	N	0.03	polymorphism	1	0.00	rs386828956	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9169	9169	A	C	MI.1372	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	643	215	T	P	Aca/Cca	-3.34	0	0	probably_damaging	1	neutral	0.06	neutral	4.18	deleterious	-4.98	deleterious	-4.06	medium_impact	3	0.75	neutral	0.08	damaging	3.61	23.20	deleterious	0.11	0.65	NA	NA	0.91	disease	0.67	disease	0.81	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	-0.38	medium_impact	1.47	medium_impact	0.52	0.9	46.9	8.38	0.25	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4926	4926	C	G	MI.13720	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	457	153	L	V	Ctt/Gtt	-9.87	0	0	benign	0	neutral	0.35	neutral	4.61	neutral	-0.87	neutral	-1.74	low_impact	1.77	0.92	neutral	0.79	neutral	0.36	6.27	deleterious	0.3	0.45	0.76	disease	0.3	neutral	0.45	neutral	0.62	disease	2	0.65	neutral	0.68	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	0.06	medium_impact	0.35	medium_impact	0.60	0.8	NA	NA	0.4	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4926	4926	C	A	MI.13721	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	457	153	L	I	Ctt/Att	-9.87	0	0	benign	0	neutral	0.66	neutral	4.68	neutral	-0.96	neutral	-0.98	neutral_impact	0.64	0.89	neutral	0.9	neutral	0.16	4.21	deleterious	0.25	0.45	0.57	disease	0.18	neutral	0.36	neutral	0.32	neutral	4	0.33	neutral	0.83	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.37	medium_impact	-0.61	medium_impact	0.38	0.8	NA	NA	0.38	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4926	4926	C	T	MI.13722	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	457	153	L	F	Ctt/Ttt	-9.87	0	0	benign	0.18	neutral	0.41	neutral	4.6	neutral	-2.61	deleterious	-3.02	low_impact	1.34	0.91	neutral	0.62	neutral	2.25	17.82	deleterious	0.25	0.45	0.49	neutral	0.49	neutral	0.59	disease	0.52	disease	0	0.51	neutral	0.62	deleterious	-6	neutral	0.43	neutral	-0.19	medium_impact	0.12	medium_impact	-0.02	medium_impact	0.54	0.8	NA	NA	0.3	N	0.35	polymorphism	1	0.05	rs28429662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4927	4927	T	A	MI.13723	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	458	153	L	H	cTt/cAt	-7.57	0	0	possibly_damaging	0.77	neutral	0.23	neutral	4.42	deleterious	-5.29	deleterious	-5.77	medium_impact	3.48	0.84	neutral	0.38	neutral	3.93	23.50	deleterious	0.04	0.35	0.95	disease	0.69	disease	0.75	disease	0.73	disease	5	0.85	neutral	0.23	neutral	0	NA	0.77	deleterious	-1.28	low_impact	-0.08	medium_impact	1.79	medium_impact	0.25	0.8	NA	NA	0.34	N	0.79	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4927	4927	T	G	MI.13724	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	458	153	L	R	cTt/cGt	-7.57	0	0	benign	0.33	neutral	0.14	neutral	4.43	deleterious	-4.89	deleterious	-5.01	medium_impact	3.48	0.81	neutral	0.36	neutral	3.94	23.50	deleterious	0.02	0.35	0.94	disease	0.74	disease	0.79	disease	0.75	disease	5	0.83	neutral	0.41	neutral	-3	neutral	0.64	deleterious	-0.52	medium_impact	-0.23	medium_impact	1.79	medium_impact	0.19	0.8	NA	NA	0.38	N	0.89	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4927	4927	T	C	MI.13725	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	458	153	L	P	cTt/cCt	-7.57	0	0	benign	0.29	neutral	0.08	neutral	4.45	deleterious	-4.4	deleterious	-5.72	medium_impact	2.58	0.88	neutral	0.49	neutral	3.54	23.10	deleterious	0.03	0.35	0.95	disease	0.72	disease	0.78	disease	0.75	disease	5	0.91	neutral	0.4	neutral	-3	neutral	0.65	deleterious	-0.44	medium_impact	-0.38	medium_impact	1.03	medium_impact	0.24	0.8	NA	NA	0.36	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4929	4929	C	G	MI.13726	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	460	154	L	V	Ctc/Gtc	-7.57	0	0	possibly_damaging	0.71	neutral	0.34	neutral	4.41	neutral	-1.75	neutral	-1.66	medium_impact	1.94	0.95	neutral	0.63	neutral	3.33	22.90	deleterious	0.22	0.45	0.73	disease	0.4	neutral	0.59	disease	0.61	disease	2	0.75	neutral	0.32	neutral	0	NA	0.68	deleterious	-1.15	low_impact	0.05	medium_impact	0.49	medium_impact	0.46	0.8	1.15	7.17	0.4	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4929	4929	C	A	MI.13727	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	460	154	L	I	Ctc/Atc	-7.57	0	0	possibly_damaging	0.45	neutral	0.8	neutral	4.53	neutral	-1.71	neutral	-0.91	neutral_impact	0.73	0.95	neutral	0.9	neutral	2.61	20.30	deleterious	0.24	0.45	0.59	disease	0.37	neutral	0.42	neutral	0.56	disease	1	0.34	neutral	0.68	deleterious	-3	neutral	0.55	deleterious	-0.72	medium_impact	0.54	medium_impact	-0.53	medium_impact	0.32	0.8	1.15	7.17	0.28	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4929	4929	C	T	MI.13728	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	460	154	L	F	Ctc/Ttc	-7.57	0	0	probably_damaging	0.98	neutral	0.32	neutral	4.36	deleterious	-3.01	deleterious	-3.16	low_impact	1.7	0.95	neutral	0.24	damaging	3.94	23.50	deleterious	0.18	0.45	0.8	disease	0.53	disease	0.67	disease	0.66	disease	3	0.98	deleterious	0.17	neutral	-2	neutral	0.76	deleterious	-2.34	low_impact	0.03	medium_impact	0.29	medium_impact	0.28	0.8	1.15	7.17	0.35	N	0.33	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4930	4930	T	A	MI.13729	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	461	154	L	H	cTc/cAc	-5.96	0	0	probably_damaging	0.99	neutral	0.14	neutral	4.24	deleterious	-5.54	deleterious	-5.91	high_impact	3.62	0.91	neutral	0.14	damaging	4.01	23.60	deleterious	0.04	0.35	0.96	disease	0.7	disease	0.75	disease	0.71	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-2.62	low_impact	-0.23	medium_impact	1.9	medium_impact	0.26	0.8	1.15	7.17	0.41	N	0.80	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9170	9170	C	T	MI.1373	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	644	215	T	M	aCa/aTa	2.67	0.98	0	probably_damaging	1	neutral	0.09	neutral	4.27	neutral	-2.61	deleterious	-3.15	low_impact	1.62	0.88	neutral	0.1	damaging	4.16	23.80	deleterious	0.16	0.65	NA	NA	0.7	disease	0.45	neutral	0.51	disease	0	1	deleterious	0.05	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	-0.28	medium_impact	0.29	medium_impact	0.74	0.9	46.9	8.38	0.43	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4930	4930	T	G	MI.13730	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	461	154	L	R	cTc/cGc	-5.96	0	0	probably_damaging	0.99	neutral	0.07	neutral	4.25	deleterious	-5.31	deleterious	-5.16	high_impact	3.62	0.86	neutral	0.12	damaging	4.07	23.70	deleterious	0.02	0.35	0.95	disease	0.76	disease	0.78	disease	0.77	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.86	deleterious	-2.62	low_impact	-0.42	medium_impact	1.9	medium_impact	0.20	0.8	1.15	7.17	0.36	N	0.85	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4930	4930	T	C	MI.13731	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	461	154	L	P	cTc/cCc	-5.96	0	0	probably_damaging	0.99	neutral	0.05	neutral	4.24	deleterious	-5.69	deleterious	-5.87	medium_impact	2.93	0.93	neutral	0.15	damaging	3.82	23.40	deleterious	0.02	0.35	0.93	disease	0.72	disease	0.79	disease	0.74	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.84	deleterious	-2.62	low_impact	-0.5	medium_impact	1.32	medium_impact	0.41	0.8	1.15	7.17	0.45	N	0.91	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4932	4932	C	G	MI.13732	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	463	155	L	V	Ctc/Gtc	-9.41	0	0	possibly_damaging	0.79	neutral	0.52	neutral	4.55	neutral	-0.88	neutral	-1.87	low_impact	0.97	0.9	neutral	0.94	neutral	2.26	17.88	deleterious	0.2	0.45	0.68	disease	0.19	neutral	0.32	neutral	0.49	neutral	0	0.77	neutral	0.37	neutral	-3	neutral	0.64	deleterious	-1.32	low_impact	0.23	medium_impact	-0.33	medium_impact	0.37	0.8	3.75	9.12	0.39	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4932	4932	C	T	MI.13733	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	463	155	L	F	Ctc/Ttc	-9.41	0	0	probably_damaging	0.95	neutral	0.51	neutral	4.44	neutral	-2.23	deleterious	-3.08	low_impact	1.55	0.93	neutral	0.76	neutral	2.88	21.80	deleterious	0.2	0.45	0.61	disease	0.35	neutral	0.36	neutral	0.6	disease	2	0.95	neutral	0.28	neutral	-2	neutral	0.69	deleterious	-1.97	low_impact	0.22	medium_impact	0.16	medium_impact	0.42	0.8	3.75	9.12	0.33	N	0.55	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4932	4932	C	A	MI.13734	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	463	155	L	I	Ctc/Atc	-9.41	0	0	possibly_damaging	0.79	neutral	0.91	neutral	4.55	neutral	-0.78	neutral	-1.36	low_impact	0.92	0.88	neutral	0.96	neutral	2.42	18.98	deleterious	0.25	0.45	0.54	disease	0.12	neutral	0.22	neutral	0.29	neutral	4	0.77	neutral	0.56	deleterious	-3	neutral	0.63	deleterious	-1.32	low_impact	0.77	medium_impact	-0.37	medium_impact	0.37	0.8	3.75	9.12	0.31	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4933	4933	T	G	MI.13735	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	464	155	L	R	cTc/cGc	-10.1	0	0	probably_damaging	0.98	neutral	0.28	neutral	4.37	deleterious	-4.15	deleterious	-4.62	medium_impact	3.35	0.84	neutral	0.38	neutral	4.15	23.80	deleterious	0.02	0.35	0.93	disease	0.67	disease	0.69	disease	0.72	disease	4	0.98	neutral	0.15	neutral	1	deleterious	0.84	deleterious	-2.34	low_impact	-0.02	medium_impact	1.68	medium_impact	0.20	0.8	3.75	9.12	0.35	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4933	4933	T	C	MI.13736	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	464	155	L	P	cTc/cCc	-10.1	0	0	probably_damaging	0.99	neutral	0.17	neutral	4.37	deleterious	-4.74	deleterious	-5.47	medium_impact	2.54	0.93	neutral	0.57	neutral	3.84	23.40	deleterious	0.02	0.35	0.92	disease	0.73	disease	0.7	disease	0.67	disease	3	0.99	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-2.62	low_impact	-0.17	medium_impact	0.99	medium_impact	0.25	0.8	3.75	9.12	0.47	N	0.94	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4933	4933	T	A	MI.13737	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	464	155	L	H	cTc/cAc	-10.1	0	0	probably_damaging	0.99	neutral	0.29	neutral	4.37	deleterious	-4.73	deleterious	-5.55	medium_impact	3.35	0.85	neutral	0.41	neutral	4.09	23.70	deleterious	0.05	0.35	0.9	disease	0.52	disease	0.64	disease	0.69	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-2.62	low_impact	-0.01	medium_impact	1.68	medium_impact	0.22	0.8	3.75	9.12	0.38	N	0.85	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4935	4935	A	T	MI.13738	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	466	156	T	S	Act/Tct	-6.19	0	0	benign	0.14	neutral	0.58	neutral	4.57	neutral	-1.16	neutral	-2.06	neutral_impact	0.68	0.74	neutral	0.96	neutral	0.10	3.61	deleterious	0.34	0.5	0.4	neutral	0.3	neutral	0.33	neutral	0.44	neutral	1	0.32	neutral	0.72	deleterious	-6	neutral	0.28	neutral	-0.08	medium_impact	0.29	medium_impact	-0.57	medium_impact	0.54	0.8	2.59	7.69	0.33	N	0.37	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4935	4935	A	C	MI.13739	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	466	156	T	P	Act/Cct	-6.19	0	0	possibly_damaging	0.46	neutral	0.21	neutral	4.53	deleterious	-3.1	deleterious	-3.43	low_impact	1.24	0.93	neutral	0.77	neutral	2.03	16.40	deleterious	0.05	0.35	0.86	disease	0.74	disease	0.54	disease	0.48	neutral	0	0.76	neutral	0.38	neutral	-3	neutral	0.70	deleterious	-0.73	medium_impact	-0.11	medium_impact	-0.1	medium_impact	0.41	0.8	2.59	7.69	0.41	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9170	9170	C	A	MI.1374	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	644	215	T	K	aCa/aAa	2.67	0.98	0	probably_damaging	1	neutral	0.05	neutral	4.2	deleterious	-4.07	deleterious	-4.04	medium_impact	3	0.85	neutral	0.08	damaging	4.54	24.30	deleterious	0.11	0.65	NA	NA	0.85	disease	0.66	disease	0.79	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.43	medium_impact	1.47	medium_impact	0.64	0.9	46.9	8.38	0.41	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4935	4935	A	G	MI.13740	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	466	156	T	A	Act/Gct	-6.19	0	0	benign	0	neutral	0.61	neutral	4.63	neutral	-0.15	neutral	-2.17	low_impact	1.04	0.97	neutral	0.96	neutral	0.20	4.72	deleterious	0.19	0.45	0.52	disease	0.25	neutral	0.35	neutral	0.34	neutral	3	0.38	neutral	0.81	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.32	medium_impact	-0.27	medium_impact	0.22	0.8	2.59	7.69	0.28	N	0.73	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4936	4936	C	T	MI.13741	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	467	156	T	I	aCt/aTt	-5.96	0	0	benign	0.01	neutral	0.5	neutral	4.84	neutral	1.44	neutral	-2.23	neutral_impact	0.61	0.95	neutral	0.96	neutral	1.88	15.45	deleterious	0.1	0.4	0.4	neutral	0.43	neutral	0.35	neutral	0.44	neutral	1	0.48	neutral	0.75	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.21	medium_impact	-0.63	medium_impact	0.50	0.8	2.59	7.69	0.35	N	0.45	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4936	4936	C	A	MI.13742	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	467	156	T	N	aCt/aAt	-5.96	0	0	possibly_damaging	0.55	neutral	0.34	neutral	4.53	neutral	-2.81	deleterious	-3.21	medium_impact	2.58	0.85	neutral	0.47	neutral	2.20	17.51	deleterious	0.19	0.45	0.83	disease	0.51	disease	0.48	neutral	0.48	neutral	0	0.66	neutral	0.4	neutral	0	NA	0.66	deleterious	-0.88	medium_impact	0.05	medium_impact	1.03	medium_impact	0.46	0.8	2.59	7.69	0.34	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4936	4936	C	G	MI.13743	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	467	156	T	S	aCt/aGt	-5.96	0	0	benign	0.14	neutral	0.58	neutral	4.57	neutral	-1.16	neutral	-2.06	neutral_impact	0.68	0.74	neutral	0.96	neutral	0.31	5.77	deleterious	0.34	0.5	0.4	neutral	0.3	neutral	0.33	neutral	0.44	neutral	1	0.32	neutral	0.72	deleterious	-6	neutral	0.28	neutral	-0.08	medium_impact	0.29	medium_impact	-0.57	medium_impact	0.54	0.8	2.59	7.69	0.32	N	0.37	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4938	4938	C	G	MI.13744	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	469	157	L	V	Ctc/Gtc	-12.63	0	0	benign	0.22	neutral	0.54	neutral	4.51	neutral	-1.64	neutral	-0.63	low_impact	1.5	0.93	neutral	0.67	neutral	0.59	8.07	deleterious	0.26	0.45	0.55	disease	0.47	neutral	0.62	disease	0.63	disease	3	0.35	neutral	0.66	deleterious	-6	neutral	0.44	deleterious	-0.29	medium_impact	0.25	medium_impact	0.12	medium_impact	0.57	0.8	5.48	8.98	0.28	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4938	4938	C	T	MI.13745	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	469	157	L	F	Ctc/Ttc	-12.63	0	0	benign	0.05	neutral	0.74	neutral	4.38	neutral	-2.39	neutral	-1.99	low_impact	1.7	0.94	neutral	0.84	neutral	0.82	9.61	deleterious	0.2	0.45	0.47	neutral	0.59	disease	0.46	neutral	0.17	neutral	7	0.18	neutral	0.85	deleterious	-6	neutral	0.20	neutral	0.37	medium_impact	0.46	medium_impact	0.29	medium_impact	0.48	0.8	5.48	8.98	0.22	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4938	4938	C	A	MI.13746	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	469	157	L	I	Ctc/Atc	-12.63	0	0	benign	0.04	neutral	0.43	neutral	4.59	neutral	-1.5	neutral	-0.46	low_impact	1.06	0.92	neutral	0.93	neutral	0.96	10.46	neutral	0.23	0.45	0.36	neutral	0.46	neutral	0.35	neutral	0.39	neutral	2	0.54	neutral	0.7	deleterious	-6	neutral	0.19	neutral	0.47	medium_impact	0.14	medium_impact	-0.25	medium_impact	0.44	0.8	5.48	8.98	0.39	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4939	4939	T	C	MI.13747	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	470	157	L	P	cTc/cCc	-2.5	0	0	probably_damaging	0.92	neutral	0.2	neutral	4.3	deleterious	-5.74	deleterious	-3.76	medium_impact	2.38	0.74	neutral	0.35	neutral	3.80	23.40	deleterious	0.02	0.35	0.93	disease	0.86	disease	0.75	disease	0.65	disease	3	0.95	neutral	0.14	neutral	1	deleterious	0.85	deleterious	-1.77	low_impact	-0.13	medium_impact	0.86	medium_impact	0.33	0.8	5.48	8.98	0.3	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4939	4939	T	G	MI.13748	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	470	157	L	R	cTc/cGc	-2.5	0	0	possibly_damaging	0.89	neutral	0.34	neutral	4.31	deleterious	-5.39	deleterious	-3.15	medium_impact	3.42	0.81	neutral	0.4	neutral	4.07	23.70	deleterious	0.02	0.35	0.9	disease	0.85	disease	0.75	disease	0.64	disease	3	0.9	neutral	0.23	neutral	0	NA	0.83	deleterious	-1.63	low_impact	0.05	medium_impact	1.73	medium_impact	0.20	0.8	5.48	8.98	0.36	N	0.96	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4939	4939	T	A	MI.13749	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	470	157	L	H	cTc/cAc	-2.5	0	0	probably_damaging	0.95	neutral	0.54	neutral	4.3	deleterious	-5.91	deleterious	-3.87	medium_impact	3.42	0.84	neutral	0.46	neutral	4.03	23.60	deleterious	0.04	0.35	0.93	disease	0.73	disease	0.72	disease	0.7	disease	4	0.94	neutral	0.3	neutral	1	deleterious	0.80	deleterious	-1.97	low_impact	0.25	medium_impact	1.73	medium_impact	0.30	0.8	5.48	8.98	0.27	N	0.85	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9172	9172	C	A	MI.1375	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	646	216	L	I	Ctt/Att	-14.68	0	0	probably_damaging	0.99	neutral	0.25	neutral	4.47	neutral	-0.6	neutral	-1.72	low_impact	1.1	0.85	neutral	0.16	damaging	4.26	23.90	deleterious	0.29	0.65	NA	NA	0.43	neutral	0.27	neutral	0.22	neutral	6	0.99	deleterious	0.13	neutral	-2	neutral	0.78	deleterious	-2.65	low_impact	0.02	medium_impact	-0.16	medium_impact	0.64	0.9	48.23	8.94	0.32	N	0.87	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4941	4941	T	G	MI.13750	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	472	158	S	A	Tca/Gca	-0.43	0	0	probably_damaging	1	neutral	0.52	neutral	4.65	neutral	1.29	neutral	0.12	neutral_impact	-0.84	0.93	neutral	0.97	neutral	0.90	10.08	neutral	0.27	0.45	0.5	neutral	0.1	neutral	0.3	neutral	0.17	neutral	7	0.99	deleterious	0.26	neutral	-2	neutral	0.68	deleterious	-3.54	low_impact	0.23	medium_impact	-1.85	low_impact	0.45	0.8	0.29	7.41	0.47	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4941	4941	T	A	MI.13751	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	472	158	S	T	Tca/Aca	-0.43	0	0	probably_damaging	1	neutral	0.39	neutral	4.48	neutral	-1.94	neutral	-1.83	low_impact	1.82	0.91	neutral	0.36	neutral	3.67	23.20	deleterious	0.28	0.45	0.67	disease	0.4	neutral	0.58	disease	0.66	disease	3	1	deleterious	0.2	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	0.1	medium_impact	0.39	medium_impact	0.62	0.8	0.29	7.41	0.42	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4941	4941	T	C	MI.13752	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	472	158	S	P	Tca/Cca	-0.43	0	0	probably_damaging	1	neutral	0.2	neutral	4.44	deleterious	-4.15	deleterious	-3.15	medium_impact	2.5	0.7	neutral	0.1	damaging	3.93	23.50	deleterious	0.04	0.35	0.89	disease	0.9	disease	0.72	disease	0.67	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.88	deleterious	-3.54	low_impact	-0.13	medium_impact	0.96	medium_impact	0.27	0.8	0.29	7.41	0.26	N	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4942	4942	C	G	MI.13753	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	473	158	S	W	tCa/tGa	0.72	0	0	probably_damaging	1	neutral	0.19	neutral	4.43	deleterious	-5.48	deleterious	-4.84	medium_impact	2.16	0.86	neutral	0.12	damaging	4.30	24.00	deleterious	0.05	0.35	0.92	disease	0.88	disease	0.64	disease	0.67	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	-0.14	medium_impact	0.67	medium_impact	0.15	0.8	0.29	7.41	0.29	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4942	4942	C	T	MI.13754	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	473	158	S	L	tCa/tTa	0.72	0	0	probably_damaging	1	neutral	0.66	neutral	4.56	neutral	-1.92	deleterious	-3.81	low_impact	1.26	0.88	neutral	0.15	damaging	4.60	24.40	deleterious	0.06	0.35	0.41	neutral	0.77	disease	0.56	disease	0.7	disease	4	1	deleterious	0.33	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.37	medium_impact	-0.08	medium_impact	0.37	0.8	0.29	7.41	0.25	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4944	4944	A	T	MI.13755	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	475	159	I	F	Atc/Ttc	-14.47	0	0	benign	0.39	neutral	0.71	neutral	4.47	neutral	-2.17	neutral	-2.34	medium_impact	1.97	0.93	neutral	0.95	neutral	3.37	22.90	deleterious	0.17	0.45	0.59	disease	0.67	disease	0.55	disease	0.56	disease	1	0.29	neutral	0.66	deleterious	-3	neutral	0.48	deleterious	-0.62	medium_impact	0.42	medium_impact	0.51	medium_impact	0.38	0.8	NA	NA	0.24	N	0.68	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4944	4944	A	G	MI.13756	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	475	159	I	V	Atc/Gtc	-14.47	0	0	benign	0.01	neutral	0.6	neutral	4.61	neutral	0.39	neutral	-0.44	low_impact	0.96	0.93	neutral	0.96	neutral	-0.20	1.10	neutral	0.44	0.55	0.51	disease	0.21	neutral	0.39	neutral	0.28	neutral	4	0.38	neutral	0.8	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.31	medium_impact	-0.34	medium_impact	0.34	0.8	NA	NA	0.33	N	0.10	polymorphism	1	0.01	rs878971699	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4944	4944	A	C	MI.13757	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	475	159	I	L	Atc/Ctc	-14.47	0	0	benign	0.01	neutral	1	neutral	4.59	neutral	0.05	neutral	0.16	neutral_impact	-0.05	0.9	neutral	0.97	neutral	-0.53	0.18	neutral	0.26	0.45	0.36	neutral	0.22	neutral	0.25	neutral	0.41	neutral	2	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	1.87	high_impact	-1.19	low_impact	0.39	0.8	NA	NA	0.36	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4945	4945	T	A	MI.13758	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	476	159	I	N	aTc/aAc	-8.26	0	0	benign	0.39	neutral	0.37	neutral	4.4	deleterious	-4.57	deleterious	-4.58	medium_impact	2.74	0.89	neutral	0.49	neutral	2.93	22.00	deleterious	0.15	0.4	0.89	disease	0.73	disease	0.62	disease	0.67	disease	3	0.57	neutral	0.49	deleterious	-3	neutral	0.62	deleterious	-0.62	medium_impact	0.08	medium_impact	1.16	medium_impact	0.26	0.8	NA	NA	0.37	N	0.88	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4945	4945	T	G	MI.13759	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	476	159	I	S	aTc/aGc	-8.26	0	0	benign	0.14	neutral	0.59	neutral	4.51	neutral	-2.8	deleterious	-3.53	medium_impact	2.19	0.89	neutral	0.49	neutral	2.40	18.80	deleterious	0.06	0.35	0.62	disease	0.75	disease	0.58	disease	0.67	disease	3	0.3	neutral	0.73	deleterious	-3	neutral	0.33	neutral	-0.08	medium_impact	0.3	medium_impact	0.7	medium_impact	0.17	0.8	NA	NA	0.23	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9172	9172	C	G	MI.1376	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	646	216	L	V	Ctt/Gtt	-14.68	0	0	probably_damaging	0.99	neutral	0.21	neutral	4.4	neutral	-0.59	deleterious	-2.62	low_impact	1.93	0.74	neutral	0.14	damaging	3.58	23.20	deleterious	0.29	0.65	NA	NA	0.39	neutral	0.31	neutral	0.19	neutral	6	0.99	deleterious	0.11	neutral	-2	neutral	0.78	deleterious	-2.65	low_impact	-0.03	medium_impact	0.56	medium_impact	0.60	0.9	48.23	8.94	0.32	N	0.87	polymorphism	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4945	4945	T	C	MI.13760	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	476	159	I	T	aTc/aCc	-8.26	0	0	benign	0.01	neutral	0.54	neutral	4.49	neutral	-2.32	neutral	-2.43	low_impact	1.75	0.98	neutral	0.95	neutral	0.20	4.72	deleterious	0.1	0.4	0.68	disease	0.43	neutral	0.43	neutral	0.58	disease	2	0.45	neutral	0.77	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	0.25	medium_impact	0.33	medium_impact	0.27	0.8	NA	NA	0.31	N	0.40	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4946	4946	C	A	MI.13761	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	477	159	I	M	atC/atA	3.02	0.15	0	benign	0.06	neutral	0.31	neutral	4.43	neutral	-2.6	neutral	-0.41	low_impact	1.43	0.91	neutral	0.95	neutral	2.25	17.86	deleterious	0.35	0.5	0.56	disease	0.35	neutral	0.38	neutral	0.6	disease	2	0.66	neutral	0.63	deleterious	-6	neutral	0.19	neutral	0.3	medium_impact	0.02	medium_impact	0.06	medium_impact	0.46	0.8	NA	NA	0.46	N	0.68	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4946	4946	C	G	MI.13762	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	477	159	I	M	atC/atG	3.02	0.15	0	benign	0.06	neutral	0.31	neutral	4.43	neutral	-2.6	neutral	-0.41	low_impact	1.43	0.91	neutral	0.95	neutral	1.84	15.20	deleterious	0.35	0.5	0.56	disease	0.35	neutral	0.38	neutral	0.6	disease	2	0.66	neutral	0.63	deleterious	-6	neutral	0.19	neutral	0.3	medium_impact	0.02	medium_impact	0.06	medium_impact	0.46	0.8	NA	NA	0.46	N	0.68	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4947	4947	T	A	MI.13763	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	478	160	L	M	Tta/Ata	-8.49	0	0	possibly_damaging	0.46	neutral	0.38	neutral	4.36	deleterious	-3.74	neutral	-1.2	low_impact	1.4	0.91	neutral	0.92	neutral	2.16	17.27	deleterious	0.3	0.45	0.68	disease	0.23	neutral	0.39	neutral	0.55	disease	1	0.58	neutral	0.46	neutral	-3	neutral	0.56	deleterious	-0.73	medium_impact	0.09	medium_impact	0.03	medium_impact	0.61	0.8	NA	NA	0.42	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4947	4947	T	G	MI.13764	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	478	160	L	V	Tta/Gta	-8.49	0	0	possibly_damaging	0.79	neutral	0.62	neutral	4.48	neutral	-1.3	neutral	-2.07	medium_impact	1.97	0.94	neutral	0.71	neutral	2.30	18.19	deleterious	0.27	0.45	0.67	disease	0.41	neutral	0.43	neutral	0.62	disease	2	0.76	neutral	0.42	neutral	0	NA	0.66	deleterious	-1.32	low_impact	0.33	medium_impact	0.51	medium_impact	0.59	0.8	NA	NA	0.29	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4948	4948	T	C	MI.13765	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	479	160	L	S	tTa/tCa	-9.87	0	0	probably_damaging	0.95	neutral	0.71	neutral	4.34	deleterious	-3.96	deleterious	-4.47	low_impact	1.55	0.91	neutral	0.81	neutral	2.66	20.60	deleterious	0.07	0.35	0.83	disease	0.51	disease	0.49	neutral	0.36	neutral	3	0.95	neutral	0.38	neutral	-2	neutral	0.75	deleterious	-1.97	low_impact	0.42	medium_impact	0.16	medium_impact	0.30	0.8	NA	NA	0.32	N	0.33	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4948	4948	T	G	MI.13766	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	479	160	L	W	tTa/tGa	-9.87	0	0	probably_damaging	0.99	neutral	0.2	neutral	4.35	deleterious	-6.21	deleterious	-4.95	medium_impact	2.96	0.82	neutral	0.4	neutral	3.75	23.30	deleterious	0.05	0.35	0.97	disease	0.69	disease	0.65	disease	0.72	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.80	deleterious	-2.62	low_impact	-0.13	medium_impact	1.35	medium_impact	0.28	0.8	NA	NA	0.34	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4949	4949	A	T	MI.13767	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	480	160	L	F	ttA/ttT	-0.2	0	0	probably_damaging	0.95	neutral	0.75	neutral	4.4	neutral	-2.85	deleterious	-3.27	low_impact	1.85	0.85	neutral	0.6	neutral	3.57	23.10	deleterious	0.19	0.45	0.57	disease	0.53	disease	0.56	disease	0.55	disease	1	0.95	neutral	0.4	neutral	-2	neutral	0.70	deleterious	-1.97	low_impact	0.47	medium_impact	0.41	medium_impact	0.61	0.8	NA	NA	0.22	N	0.50	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4949	4949	A	C	MI.13768	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	480	160	L	F	ttA/ttC	-0.2	0	0	probably_damaging	0.95	neutral	0.75	neutral	4.4	neutral	-2.85	deleterious	-3.27	low_impact	1.85	0.85	neutral	0.6	neutral	3.48	23.10	deleterious	0.19	0.45	0.57	disease	0.53	disease	0.56	disease	0.55	disease	1	0.95	neutral	0.4	neutral	-2	neutral	0.70	deleterious	-1.97	low_impact	0.47	medium_impact	0.41	medium_impact	0.61	0.8	NA	NA	0.22	N	0.50	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4950	4950	T	G	MI.13769	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	481	161	S	A	Tcc/Gcc	-3.65	0	0	probably_damaging	1	neutral	0.51	neutral	4.37	neutral	-1.94	deleterious	-2.95	medium_impact	3.31	0.9	neutral	0.57	neutral	3.56	23.10	deleterious	0.11	0.4	0.53	disease	0.58	disease	0.65	disease	0.63	disease	3	0.99	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.22	medium_impact	1.64	medium_impact	0.39	0.8	NA	NA	0.36	N	0.49	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9172	9172	C	T	MI.1377	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	646	216	L	F	Ctt/Ttt	-14.68	0	0	probably_damaging	1	deleterious	0.02	neutral	4.28	neutral	-2.67	deleterious	-3.54	medium_impact	3.25	0.76	neutral	0.13	damaging	4.07	23.70	deleterious	0.39	0.65	NA	NA	0.76	disease	0.56	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.66	medium_impact	1.69	medium_impact	0.61	0.9	48.23	8.94	0.27	N	0.97	polymorphism	0.9	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4950	4950	T	C	MI.13770	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	481	161	S	P	Tcc/Ccc	-3.65	0	0	probably_damaging	1	neutral	0.2	neutral	4.29	deleterious	-5.73	deleterious	-4.91	high_impact	4.12	0.74	neutral	0.51	neutral	3.90	23.50	deleterious	0.03	0.35	0.89	disease	0.81	disease	0.81	disease	0.66	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.13	medium_impact	2.32	high_impact	0.35	0.8	NA	NA	0.47	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4950	4950	T	A	MI.13771	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	481	161	S	T	Tcc/Acc	-3.65	0	0	probably_damaging	1	neutral	0.44	neutral	4.51	neutral	-0.36	deleterious	-2.95	medium_impact	2.73	0.8	neutral	0.46	neutral	3.69	23.30	deleterious	0.16	0.45	0.43	neutral	0.58	disease	0.68	disease	0.65	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.15	medium_impact	1.15	medium_impact	0.57	0.8	NA	NA	0.29	N	0.71	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4951	4951	C	T	MI.13772	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	482	161	S	F	tCc/tTc	7.4	1	0	probably_damaging	1	neutral	0.72	neutral	4.28	deleterious	-6.18	deleterious	-5.89	high_impact	3.77	0.87	neutral	0.48	neutral	4.14	23.80	deleterious	0.03	0.35	0.4	neutral	0.85	disease	0.73	disease	0.69	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	0.44	medium_impact	2.03	high_impact	0.12	0.8	NA	NA	0.55	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4951	4951	C	A	MI.13773	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	482	161	S	Y	tCc/tAc	7.4	1	0	probably_damaging	1	neutral	1	neutral	4.29	deleterious	-6.21	deleterious	-5.89	high_impact	4.12	0.8	neutral	0.41	neutral	4.12	23.80	deleterious	0.03	0.35	0.45	neutral	0.83	disease	0.73	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.74	deleterious	-3.54	low_impact	1.87	high_impact	2.32	high_impact	0.26	0.8	NA	NA	0.54	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4951	4951	C	G	MI.13774	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	482	161	S	C	tCc/tGc	7.4	1	0	probably_damaging	1	neutral	0.18	neutral	4.28	deleterious	-6.47	deleterious	-4.91	medium_impact	3.08	0.79	neutral	0.44	neutral	3.51	23.10	deleterious	0.03	0.35	0.81	disease	0.76	disease	0.7	disease	0.66	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.16	medium_impact	1.45	medium_impact	0.23	0.8	NA	NA	0.58	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4953	4953	A	G	MI.13775	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	484	162	I	V	Atc/Gtc	-8.72	0	0	benign	0.02	neutral	0.6	neutral	4.61	neutral	-0.74	neutral	-0.71	neutral_impact	0.46	0.93	neutral	0.98	neutral	-0.48	0.25	neutral	0.55	0.6	0.36	neutral	0.17	neutral	0.39	neutral	0.29	neutral	4	0.37	neutral	0.79	deleterious	-6	neutral	0.11	neutral	0.75	medium_impact	0.31	medium_impact	-0.76	medium_impact	0.36	0.8	NA	NA	0.34	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4953	4953	A	C	MI.13776	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	484	162	I	L	Atc/Ctc	-8.72	0	0	benign	0.22	neutral	0.95	neutral	4.64	neutral	-0.19	neutral	-1.91	low_impact	1.31	0.9	neutral	0.72	neutral	1.88	15.45	deleterious	0.27	0.45	0.42	neutral	0.53	disease	0.46	neutral	0.32	neutral	4	0.14	neutral	0.87	deleterious	-6	neutral	0.33	neutral	-0.29	medium_impact	0.92	medium_impact	-0.04	medium_impact	0.48	0.8	NA	NA	0.25	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4953	4953	A	T	MI.13777	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	484	162	I	F	Atc/Ttc	-8.72	0	0	possibly_damaging	0.86	neutral	0.73	neutral	4.45	neutral	-2.7	deleterious	-3.89	medium_impact	2.73	0.9	neutral	0.4	neutral	3.58	23.20	deleterious	0.18	0.45	0.57	disease	0.66	disease	0.63	disease	0.69	disease	4	0.83	neutral	0.44	neutral	0	NA	0.69	deleterious	-1.52	low_impact	0.45	medium_impact	1.15	medium_impact	0.37	0.8	NA	NA	0.32	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4954	4954	T	C	MI.13778	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	485	162	I	T	aTc/aCc	-0.2	0	0	benign	0.06	neutral	0.56	neutral	4.49	neutral	-2.47	deleterious	-4.59	neutral_impact	0.1	0.92	neutral	0.94	neutral	0.19	4.62	deleterious	0.16	0.45	0.43	neutral	0.13	neutral	0.35	neutral	0.24	neutral	5	0.37	neutral	0.75	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	0.27	medium_impact	-1.06	low_impact	0.23	0.8	NA	NA	0.39	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4954	4954	T	G	MI.13779	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	485	162	I	S	aTc/aGc	-0.2	0	0	possibly_damaging	0.58	neutral	0.62	neutral	4.47	neutral	-2.99	deleterious	-5.71	low_impact	1.06	0.87	neutral	0.59	neutral	3.90	23.50	deleterious	0.04	0.35	0.41	neutral	0.67	disease	0.54	disease	0.46	neutral	1	0.51	neutral	0.52	deleterious	-3	neutral	0.55	deleterious	-0.93	medium_impact	0.33	medium_impact	-0.25	medium_impact	0.20	0.8	NA	NA	0.24	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9173	9173	T	C	MI.1378	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	647	216	L	P	cTt/cCt	0.36	0.05	0	probably_damaging	1	deleterious	0.01	neutral	4.25	deleterious	-4.92	deleterious	-6.24	high_impact	4.05	0.74	neutral	0.14	damaging	4.04	23.70	deleterious	0.11	0.65	NA	NA	0.87	disease	0.68	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-0.84	medium_impact	2.37	high_impact	0.67	0.9	48.23	8.94	0.34	N	1.00	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4954	4954	T	A	MI.13780	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	485	162	I	N	aTc/aAc	-0.2	0	0	possibly_damaging	0.86	neutral	0.33	neutral	4.42	deleterious	-4.69	deleterious	-6.69	medium_impact	2.38	0.88	neutral	0.46	neutral	4.30	24.00	deleterious	0.1	0.4	0.76	disease	0.74	disease	0.62	disease	0.7	disease	4	0.87	neutral	0.24	neutral	0	NA	0.73	deleterious	-1.52	low_impact	0.04	medium_impact	0.86	medium_impact	0.20	0.8	NA	NA	0.35	N	0.90	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4955	4955	C	A	MI.13781	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	486	162	I	M	atC/atA	0.95	0	0	possibly_damaging	0.86	neutral	0.26	neutral	4.61	neutral	0.5	deleterious	-2.75	low_impact	1.39	0.91	neutral	0.67	neutral	3.61	23.20	deleterious	0.38	0.5	0.61	disease	0.42	neutral	0.37	neutral	0.59	disease	2	0.89	neutral	0.2	neutral	-3	neutral	0.67	deleterious	-1.52	low_impact	-0.04	medium_impact	0.03	medium_impact	0.49	0.8	NA	NA	0.43	N	0.63	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4955	4955	C	G	MI.13782	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	486	162	I	M	atC/atG	0.95	0	0	possibly_damaging	0.86	neutral	0.26	neutral	4.61	neutral	0.5	deleterious	-2.75	low_impact	1.39	0.91	neutral	0.67	neutral	3.09	22.50	deleterious	0.38	0.5	0.61	disease	0.42	neutral	0.37	neutral	0.59	disease	2	0.89	neutral	0.2	neutral	-3	neutral	0.67	deleterious	-1.52	low_impact	-0.04	medium_impact	0.03	medium_impact	0.49	0.8	NA	NA	0.43	N	0.63	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4956	4956	A	C	MI.13783	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	487	163	M	L	Ata/Cta	-12.17	0	0	benign	0	neutral	0.94	neutral	5.25	neutral	3.58	neutral	-0.83	neutral_impact	-1.54	0.96	neutral	0.99	neutral	-1.33	0.00	neutral	0.28	0.45	0.49	neutral	0.26	neutral	0.3	neutral	0.4	neutral	2	0.05	neutral	0.97	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.87	medium_impact	-2.44	low_impact	0.26	0.8	0.58	7.37	0.34	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4956	4956	A	G	MI.13784	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	487	163	M	V	Ata/Gta	-12.17	0	0	benign	0.08	neutral	0.61	neutral	4.72	neutral	1.14	neutral	-2.06	neutral_impact	-0.27	0.94	neutral	0.93	neutral	-0.24	0.89	neutral	0.23	0.45	0.41	neutral	0.5	disease	0.4	neutral	0.22	neutral	6	0.3	neutral	0.77	deleterious	-6	neutral	0.18	neutral	0.17	medium_impact	0.32	medium_impact	-1.37	low_impact	0.29	0.8	0.58	7.37	0.28	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4956	4956	A	T	MI.13785	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	487	163	M	L	Ata/Tta	-12.17	0	0	benign	0	neutral	0.94	neutral	5.25	neutral	3.58	neutral	-0.83	neutral_impact	-1.54	0.96	neutral	0.99	neutral	-1.26	0.01	neutral	0.28	0.45	0.49	neutral	0.26	neutral	0.3	neutral	0.4	neutral	2	0.05	neutral	0.97	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.87	medium_impact	-2.44	low_impact	0.26	0.8	0.58	7.37	0.33	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4957	4957	T	A	MI.13786	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	488	163	M	K	aTa/aAa	-5.04	0	0	benign	0.17	neutral	0.37	neutral	4.58	deleterious	-3.36	deleterious	-4.38	low_impact	1.75	0.86	neutral	0.37	neutral	2.03	16.43	deleterious	0.04	0.35	0.45	neutral	0.76	disease	0.66	disease	0.72	disease	4	0.56	neutral	0.6	deleterious	-6	neutral	0.33	neutral	-0.17	medium_impact	0.08	medium_impact	0.33	medium_impact	0.17	0.8	0.58	7.37	0.28	N	0.62	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4957	4957	T	C	MI.13787	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	488	163	M	T	aTa/aCa	-5.04	0	0	benign	0.17	neutral	0.52	neutral	4.59	neutral	-1.84	deleterious	-3.8	neutral_impact	0.5	0.93	neutral	0.78	neutral	1.01	10.73	neutral	0.11	0.4	0.41	neutral	0.5	neutral	0.57	disease	0.42	neutral	2	0.38	neutral	0.68	deleterious	-6	neutral	0.27	neutral	-0.17	medium_impact	0.23	medium_impact	-0.72	medium_impact	0.11	0.8	0.58	7.37	0.3	N	0.32	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4958	4958	A	T	MI.13788	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	489	163	M	I	atA/atT	0.95	0	0.08	benign	0.05	neutral	0.54	neutral	5	neutral	2.79	neutral	-1.85	neutral_impact	-0.42	0.87	neutral	0.97	neutral	0.20	4.71	deleterious	0.27	0.45	0.36	neutral	0.45	neutral	0.36	neutral	0.42	neutral	2	0.41	neutral	0.75	deleterious	-6	neutral	0.18	neutral	0.37	medium_impact	0.25	medium_impact	-1.5	low_impact	0.36	0.8	0.58	7.37	0.37	N	0.16	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4958	4958	A	C	MI.13789	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	489	163	M	I	atA/atC	0.95	0	0.08	benign	0.05	neutral	0.54	neutral	5	neutral	2.79	neutral	-1.85	neutral_impact	-0.42	0.87	neutral	0.97	neutral	0.09	3.48	deleterious	0.27	0.45	0.36	neutral	0.45	neutral	0.36	neutral	0.42	neutral	2	0.41	neutral	0.75	deleterious	-6	neutral	0.18	neutral	0.37	medium_impact	0.25	medium_impact	-1.5	low_impact	0.36	0.8	0.58	7.37	0.37	N	0.16	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9173	9173	T	A	MI.1379	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	647	216	L	H	cTt/cAt	0.36	0.05	0	probably_damaging	1	deleterious	0.02	neutral	4.25	deleterious	-4.88	deleterious	-6.23	high_impact	4.05	0.76	neutral	0.13	damaging	4.36	24.10	deleterious	0.14	0.65	NA	NA	0.83	disease	0.64	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-0.66	medium_impact	2.37	high_impact	0.58	0.9	48.23	8.94	0.33	N	0.97	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4959	4959	G	T	MI.13790	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	490	164	A	S	Gca/Tca	-3.42	0	0.02	benign	0.29	neutral	0.45	neutral	4.62	neutral	-1.74	neutral	-1.48	neutral_impact	0.72	0.86	neutral	0.64	neutral	1.93	15.76	deleterious	0.23	0.45	0.37	neutral	0.36	neutral	0.45	neutral	0.44	neutral	1	0.46	neutral	0.58	deleterious	-6	neutral	0.36	neutral	-0.44	medium_impact	0.16	medium_impact	-0.54	medium_impact	0.35	0.8	NA	NA	0.31	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4959	4959	G	C	MI.13791	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	490	164	A	P	Gca/Cca	-3.42	0	0.02	possibly_damaging	0.75	neutral	0.22	neutral	4.59	deleterious	-3.75	neutral	-2.23	low_impact	1.07	0.86	neutral	0.38	neutral	3.47	23.00	deleterious	0.06	0.35	0.89	disease	0.8	disease	0.62	disease	0.7	disease	4	0.85	neutral	0.24	neutral	-3	neutral	0.78	deleterious	-1.23	low_impact	-0.1	medium_impact	-0.24	medium_impact	0.34	0.8	NA	NA	0.28	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4959	4959	G	A	MI.13792	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	490	164	A	T	Gca/Aca	-3.42	0	0.02	benign	0.03	neutral	0.42	neutral	4.63	neutral	-0.75	neutral	-0.36	neutral_impact	-0.36	0.94	neutral	0.84	neutral	1.23	11.92	neutral	0.17	0.45	0.4	neutral	0.29	neutral	0.24	neutral	0.46	neutral	1	0.55	neutral	0.7	deleterious	-6	neutral	0.13	neutral	0.59	medium_impact	0.13	medium_impact	-1.45	low_impact	0.56	0.8	NA	NA	0.37	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4960	4960	C	T	MI.13793	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	491	164	A	V	gCa/gTa	-5.04	0	0.01	benign	0.01	neutral	0.52	neutral	4.78	neutral	1.04	neutral	2.91	neutral_impact	-1.65	0.96	neutral	0.98	neutral	0.24	5.08	deleterious	0.16	0.45	0.5	disease	0.15	neutral	0.2	neutral	0.17	neutral	7	0.47	neutral	0.76	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.23	medium_impact	-2.53	low_impact	0.52	0.8	NA	NA	0.34	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4960	4960	C	A	MI.13794	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	491	164	A	E	gCa/gAa	-5.04	0	0.01	possibly_damaging	0.57	neutral	0.33	neutral	4.59	deleterious	-3.49	neutral	-2.23	low_impact	1.42	0.91	neutral	0.61	neutral	2.86	21.70	deleterious	0.05	0.35	0.87	disease	0.72	disease	0.6	disease	0.68	disease	4	0.68	neutral	0.38	neutral	-3	neutral	0.63	deleterious	-0.91	medium_impact	0.04	medium_impact	0.05	medium_impact	0.31	0.8	NA	NA	0.35	N	0.55	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4960	4960	C	G	MI.13795	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	491	164	A	G	gCa/gGa	-5.04	0	0.01	possibly_damaging	0.44	neutral	0.36	neutral	4.6	neutral	-2.35	deleterious	-3.02	low_impact	1.42	0.89	neutral	0.6	neutral	2.21	17.55	deleterious	0.17	0.45	0.69	disease	0.35	neutral	0.45	neutral	0.62	disease	2	0.59	neutral	0.46	neutral	-3	neutral	0.50	deleterious	-0.7	medium_impact	0.07	medium_impact	0.05	medium_impact	0.48	0.8	NA	NA	0.42	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4962	4962	G	C	MI.13796	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	493	165	G	R	Ggc/Cgc	-11.71	0	0	probably_damaging	1	neutral	0.35	neutral	4.3	deleterious	-6.19	deleterious	-7.86	high_impact	4.13	0.81	neutral	0.09	damaging	3.94	23.50	deleterious	0.01	0.35	0.84	disease	0.92	disease	0.84	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	0.06	medium_impact	2.33	high_impact	0.68	0.85	NA	NA	0.42	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4962	4962	G	A	MI.13797	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	493	165	G	S	Ggc/Agc	-11.71	0	0	probably_damaging	1	neutral	0.44	neutral	4.38	deleterious	-4.5	deleterious	-5.89	medium_impact	2.37	0.78	neutral	0.13	damaging	4.15	23.80	deleterious	0.03	0.35	0.87	disease	0.87	disease	0.68	disease	0.62	disease	2	1	deleterious	0.22	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	0.15	medium_impact	0.85	medium_impact	0.73	0.85	NA	NA	0.28	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4962	4962	G	T	MI.13798	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	493	165	G	C	Ggc/Tgc	-11.71	0	0	probably_damaging	1	neutral	0.18	neutral	4.28	deleterious	-6.89	deleterious	-8.84	high_impact	4.13	0.78	neutral	0.08	damaging	4.12	23.80	deleterious	0.02	0.35	0.98	disease	0.93	disease	0.75	disease	0.65	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	-0.16	medium_impact	2.33	high_impact	0.24	0.8	NA	NA	0.36	N	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4963	4963	G	C	MI.13799	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	494	165	G	A	gGc/gCc	7.17	1	0	probably_damaging	1	neutral	0.51	neutral	4.5	neutral	-2.53	deleterious	-5.89	medium_impact	3.16	0.87	neutral	0.13	damaging	3.10	22.50	deleterious	0.03	0.35	0.85	disease	0.79	disease	0.66	disease	0.64	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	0.22	medium_impact	1.52	medium_impact	0.39	0.8	NA	NA	0.57	P	0.74	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8591	8591	T	G	MI.138	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	65	22	L	R	cTg/cGg	-5.89	0	0	possibly_damaging	0.8	deleterious	0.01	neutral	4.12	deleterious	-3.6	deleterious	-4.39	medium_impact	3.46	0.77	neutral	0.38	neutral	3.78	23.40	deleterious	0.15	0.65	0.84	disease	0.84	disease	0.7	disease	0.8	disease	6	0.99	deleterious	0.11	neutral	4	deleterious	0.79	deleterious	-1.33	low_impact	-0.84	medium_impact	1.87	medium_impact	0.61	0.9	25.22	20.33	0.31	N	0.45	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9173	9173	T	G	MI.1380	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	647	216	L	R	cTt/cGt	0.36	0.05	0	probably_damaging	1	neutral	0.14	neutral	4.31	deleterious	-4	deleterious	-5.35	high_impact	4.05	0.78	neutral	0.13	damaging	4.34	24.00	deleterious	0.11	0.65	NA	NA	0.9	disease	0.67	disease	0.75	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.15	medium_impact	2.37	high_impact	0.56	0.9	48.23	8.94	0.33	N	0.99	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4963	4963	G	T	MI.13800	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	494	165	G	V	gGc/gTc	7.17	1	0	probably_damaging	1	neutral	0.52	neutral	4.34	deleterious	-4.77	deleterious	-8.84	high_impact	4.13	0.69	neutral	0.1	damaging	3.74	23.30	deleterious	0.02	0.35	0.93	disease	0.91	disease	0.77	disease	0.61	disease	2	1	deleterious	0.26	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	0.23	medium_impact	2.33	high_impact	0.19	0.8	NA	NA	0.67	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4963	4963	G	A	MI.13801	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	494	165	G	D	gGc/gAc	7.17	1	0	probably_damaging	1	neutral	0.2	neutral	4.29	deleterious	-6.7	deleterious	-6.88	high_impact	4.13	0.82	neutral	0.1	damaging	3.82	23.40	deleterious	0.02	0.35	0.83	disease	0.91	disease	0.83	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	-0.13	medium_impact	2.33	high_impact	0.12	0.8	NA	NA	0.66	P	0.95	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4965	4965	A	T	MI.13802	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	496	166	S	C	Agt/Tgt	-5.73	0	0	probably_damaging	0.97	neutral	0.17	neutral	4.09	deleterious	-6.19	deleterious	-3.21	medium_impact	2.22	0.82	neutral	0.49	neutral	3.42	23.00	deleterious	0.06	0.35	0.94	disease	0.76	disease	0.59	disease	0.68	disease	4	0.98	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-2.18	low_impact	-0.17	medium_impact	0.72	medium_impact	0.35	0.8	2.59	7.82	0.32	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4965	4965	A	C	MI.13803	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	496	166	S	R	Agt/Cgt	-5.73	0	0	probably_damaging	0.93	neutral	0.35	neutral	4.1	deleterious	-4.8	neutral	-2.36	medium_impact	2.22	0.82	neutral	0.53	neutral	3.66	23.20	deleterious	0.03	0.35	0.83	disease	0.89	disease	0.71	disease	0.68	disease	4	0.93	neutral	0.21	neutral	1	deleterious	0.88	deleterious	-1.83	low_impact	0.06	medium_impact	0.72	medium_impact	0.42	0.8	2.59	7.82	0.27	N	0.62	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4965	4965	A	G	MI.13804	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	496	166	S	G	Agt/Ggt	-5.73	0	0	benign	0.04	neutral	0.56	neutral	4.31	neutral	-1.44	neutral	4.57	neutral_impact	-1.76	0.86	neutral	0.92	neutral	-1.10	0.01	neutral	0.14	0.4	0.63	disease	0.09	neutral	0.25	neutral	0.32	neutral	4	0.39	neutral	0.76	deleterious	-6	neutral	0.18	neutral	0.47	medium_impact	0.27	medium_impact	-2.63	low_impact	0.40	0.8	2.59	7.82	0.29	N	0.00	polymorphism	1	0.01	rs879150535	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4966	4966	G	A	MI.13805	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	497	166	S	N	aGt/aAt	4.86	1	0	possibly_damaging	0.81	neutral	0.36	neutral	4.16	neutral	-2.97	neutral	-0.4	low_impact	1.53	0.85	neutral	0.66	neutral	1.82	15.10	deleterious	0.4	0.5	0.78	disease	0.75	disease	0.59	disease	0.68	disease	4	0.83	neutral	0.28	neutral	-3	neutral	0.79	deleterious	-1.37	low_impact	0.07	medium_impact	0.14	medium_impact	0.44	0.8	2.59	7.82	0.55	P	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4966	4966	G	C	MI.13806	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	497	166	S	T	aGt/aCt	4.86	1	0	possibly_damaging	0.71	neutral	0.4	neutral	4.23	neutral	-2.11	neutral	-2.1	low_impact	1.25	0.9	neutral	0.7	neutral	1.79	14.95	neutral	0.2	0.45	0.43	neutral	0.46	neutral	0.59	disease	0.48	neutral	0	0.73	neutral	0.35	neutral	-3	neutral	0.68	deleterious	-1.15	low_impact	0.11	medium_impact	-0.09	medium_impact	0.55	0.8	2.59	7.82	0.6	P	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4966	4966	G	T	MI.13807	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	497	166	S	I	aGt/aTt	4.86	1	0	probably_damaging	0.95	neutral	0.41	neutral	4.09	deleterious	-5.66	deleterious	-4.19	low_impact	1.88	0.85	neutral	0.6	neutral	3.96	23.60	deleterious	0.04	0.35	0.89	disease	0.83	disease	0.61	disease	0.66	disease	3	0.95	neutral	0.23	neutral	-2	neutral	0.87	deleterious	-1.97	low_impact	0.12	medium_impact	0.44	medium_impact	0.28	0.8	2.59	7.82	0.55	P	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4968	4968	T	G	MI.13808	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	499	167	W	G	Tga/Gga	-10.56	0	0	probably_damaging	1	neutral	0.41	neutral	4.63	neutral	-1.75	deleterious	-12.77	high_impact	3.5	0.52	damaging	0.05	damaging	3.86	23.50	deleterious	0.05	0.35	0.84	disease	0.86	disease	0.8	disease	0.66	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.12	medium_impact	1.8	medium_impact	0.13	0.8	NA	NA	0.43	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4968	4968	T	C	MI.13809	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	499	167	W	R	Tga/Cga	-10.56	0	0	probably_damaging	1	neutral	0.36	neutral	4.6	neutral	-2.03	deleterious	-13.75	high_impact	3.85	0.43	damaging	0.04	damaging	3.54	23.10	deleterious	0.04	0.35	0.82	disease	0.92	disease	0.85	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	0.07	medium_impact	2.1	high_impact	0.09	0.8	NA	NA	0.52	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9175	9175	C	G	MI.1381	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	649	217	L	V	Cta/Gta	-11.67	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.23	deleterious	-6.6	deleterious	-2.67	high_impact	4.01	0.36	damaging	0.51	neutral	3.52	23.10	deleterious	0.2	0.65	NA	NA	0.62	disease	0.8	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.65	low_impact	-0.84	medium_impact	2.34	high_impact	0.68	0.9	50	9.01	0.61	P	0.87	polymorphism	0.82	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4969	4969	G	T	MI.13810	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	500	167	W	L	tGa/tTa	5.55	1	0	probably_damaging	1	neutral	0.71	neutral	4.99	neutral	2.94	deleterious	-12.77	low_impact	1.46	0.58	damaging	0.03	damaging	4.19	23.90	deleterious	0.09	0.35	0.57	disease	0.87	disease	0.77	disease	0.69	disease	4	1	deleterious	0.36	neutral	-2	neutral	0.82	deleterious	-3.54	low_impact	0.42	medium_impact	0.09	medium_impact	0.09	0.8	NA	NA	0.46	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4969	4969	G	C	MI.13811	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	500	167	W	S	tGa/tCa	5.55	1	0	probably_damaging	1	neutral	0.47	neutral	4.68	neutral	-0.82	deleterious	-13.75	high_impact	3.85	0.48	damaging	0.05	damaging	3.97	23.60	deleterious	0.06	0.35	0.74	disease	0.93	disease	0.8	disease	0.71	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.18	medium_impact	2.1	high_impact	0.14	0.8	NA	NA	0.62	P	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4970	4970	A	C	MI.13812	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	501	167	W	C	tgA/tgC	7.17	1	0	probably_damaging	1	neutral	0.17	neutral	4.6	neutral	-2.11	deleterious	-12.77	high_impact	3.5	0.55	damaging	0.03	damaging	3.98	23.60	deleterious	0.05	0.35	0.46	neutral	0.92	disease	0.83	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.17	medium_impact	1.8	medium_impact	0.11	0.8	NA	NA	0.56	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4970	4970	A	T	MI.13813	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	501	167	W	C	tgA/tgT	7.17	1	0	probably_damaging	1	neutral	0.17	neutral	4.6	neutral	-2.11	deleterious	-12.77	high_impact	3.5	0.55	damaging	0.03	damaging	4.10	23.70	deleterious	0.05	0.35	0.46	neutral	0.92	disease	0.83	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.17	medium_impact	1.8	medium_impact	0.11	0.8	NA	NA	0.57	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4971	4971	G	A	MI.13814	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	502	168	G	S	Ggt/Agt	2.1	1	0	probably_damaging	1	neutral	0.44	neutral	4.56	neutral	-0.93	deleterious	-5.89	medium_impact	2.31	0.84	neutral	0.08	damaging	4.15	23.80	deleterious	0.11	0.4	0.36	neutral	0.85	disease	0.59	disease	0.54	disease	1	1	deleterious	0.22	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.15	medium_impact	0.8	medium_impact	0.75	0.85	NA	NA	0.37	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4971	4971	G	T	MI.13815	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	502	168	G	C	Ggt/Tgt	2.1	1	0	probably_damaging	1	neutral	0.17	neutral	4.55	neutral	-2.66	deleterious	-8.84	high_impact	3.94	0.8	neutral	0.08	damaging	4.22	23.90	deleterious	0.04	0.35	0.85	disease	0.94	disease	0.69	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.17	medium_impact	2.17	high_impact	0.19	0.8	NA	NA	0.51	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4971	4971	G	C	MI.13816	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	502	168	G	R	Ggt/Cgt	2.1	1	0	probably_damaging	1	neutral	0.36	neutral	4.5	neutral	-2.48	deleterious	-7.85	high_impact	3.94	0.79	neutral	0.07	damaging	3.98	23.60	deleterious	0.03	0.35	0.47	neutral	0.93	disease	0.8	disease	0.79	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.07	medium_impact	2.17	high_impact	0.51	0.8	NA	NA	0.52	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4972	4972	G	T	MI.13817	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	503	168	G	V	gGt/gTt	2.56	1	0	probably_damaging	1	neutral	0.51	neutral	4.67	neutral	0.63	deleterious	-8.84	medium_impact	2.9	0.84	neutral	0.09	damaging	3.74	23.30	deleterious	0.05	0.35	0.57	disease	0.91	disease	0.7	disease	0.71	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.22	medium_impact	1.3	medium_impact	0.19	0.8	NA	NA	0.41	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4972	4972	G	A	MI.13818	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	503	168	G	D	gGt/gAt	2.56	1	0	probably_damaging	1	neutral	0.2	neutral	4.49	deleterious	-4.38	deleterious	-6.87	high_impact	3.94	0.82	neutral	0.07	damaging	3.75	23.30	deleterious	0.03	0.35	0.24	neutral	0.93	disease	0.79	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	-0.13	medium_impact	2.17	high_impact	0.17	0.8	NA	NA	0.54	N	0.95	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4972	4972	G	C	MI.13819	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	503	168	G	A	gGt/gCt	2.56	1	0	probably_damaging	1	neutral	0.53	neutral	4.62	neutral	0.47	deleterious	-5.89	medium_impact	2.11	0.87	neutral	0.15	damaging	3.06	22.40	deleterious	0.16	0.45	0.42	neutral	0.77	disease	0.61	disease	0.4	neutral	2	1	deleterious	0.27	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.24	medium_impact	0.63	medium_impact	0.42	0.8	NA	NA	0.36	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9175	9175	C	A	MI.1382	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	649	217	L	M	Cta/Ata	-11.67	0	0	probably_damaging	1	deleterious	0	neutral	2.21	deleterious	-7.14	neutral	-1.78	high_impact	4.57	0.43	damaging	0.6	neutral	3.86	23.50	deleterious	0.16	0.65	NA	NA	0.6	disease	0.77	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	2.82	high_impact	0.58	0.9	50	9.01	0.62	P	0.96	polymorphism	0.85	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4974	4974	G	T	MI.13820	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	505	169	G	W	Gga/Tga	-10.1	0	0	probably_damaging	1	neutral	0.19	neutral	4.33	deleterious	-4.91	deleterious	-7.84	high_impact	4.09	0.75	neutral	0.18	damaging	4.48	24.20	deleterious	0.03	0.35	0.86	disease	0.94	disease	0.76	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	-0.14	medium_impact	2.3	high_impact	0.08	0.8	NA	NA	0.39	N	0.99	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4974	4974	G	C	MI.13821	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	505	169	G	R	Gga/Cga	-10.1	0	0	probably_damaging	1	neutral	0.36	neutral	4.35	deleterious	-3.03	deleterious	-7.84	high_impact	3.75	0.77	neutral	0.18	damaging	3.96	23.60	deleterious	0.03	0.35	0.61	disease	0.93	disease	0.8	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	0.07	medium_impact	2.01	high_impact	0.59	0.8	NA	NA	0.41	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4975	4975	G	T	MI.13822	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	506	169	G	V	gGa/gTa	7.17	1	0	probably_damaging	1	neutral	0.51	neutral	4.42	neutral	-1.18	deleterious	-8.82	high_impact	4.09	0.65	neutral	0.22	damaging	3.76	23.30	deleterious	0.03	0.35	0.43	neutral	0.93	disease	0.72	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	0.22	medium_impact	2.3	high_impact	0.20	0.8	NA	NA	0.63	P	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4975	4975	G	A	MI.13823	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	506	169	G	E	gGa/gAa	7.17	1	0	probably_damaging	1	neutral	0.28	neutral	4.36	neutral	-2.83	deleterious	-7.84	high_impact	4.09	0.73	neutral	0.22	damaging	3.84	23.40	deleterious	0.03	0.35	0.39	neutral	0.93	disease	0.81	disease	0.72	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.02	medium_impact	2.3	high_impact	0.23	0.8	NA	NA	0.7	P	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4975	4975	G	C	MI.13824	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	506	169	G	A	gGa/gCa	7.17	1	0	probably_damaging	1	neutral	0.53	neutral	4.74	neutral	3.06	deleterious	-5.88	medium_impact	2.53	0.73	neutral	0.34	neutral	3.08	22.50	deleterious	0.11	0.4	0.23	neutral	0.84	disease	0.66	disease	0.68	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.24	medium_impact	0.99	medium_impact	0.46	0.8	NA	NA	0.51	N	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4977	4977	T	A	MI.13825	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	508	170	L	M	Tta/Ata	-5.73	0	0	probably_damaging	1	neutral	0.25	neutral	4.12	deleterious	-3.54	neutral	-1.96	medium_impact	2.23	0.95	neutral	0.14	damaging	3.59	23.20	deleterious	0.18	0.45	NA	NA	0.7	disease	0.59	disease	0.64	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.06	medium_impact	0.73	medium_impact	0.58	0.8	NA	NA	0.39	N	0.88	polymorphism	1	0.02	rs28357981	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	4977	4977	T	G	MI.13826	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	508	170	L	V	Tta/Gta	-5.73	0	0	probably_damaging	1	neutral	0.53	neutral	4.11	neutral	-2.17	deleterious	-2.94	medium_impact	2.69	0.82	neutral	0.13	damaging	3.43	23.00	deleterious	0.13	0.4	NA	NA	0.71	disease	0.72	disease	0.67	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.24	medium_impact	1.12	medium_impact	0.58	0.8	NA	NA	0.18	N	0.77	polymorphism	1	0.06	rs28357981	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4978	4978	T	G	MI.13827	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	509	170	L	W	tTa/tGa	0.03	0	0	probably_damaging	1	neutral	0.19	neutral	4.04	deleterious	-6.04	deleterious	-5.88	medium_impact	2.65	0.87	neutral	0.1	damaging	3.74	23.30	deleterious	0.03	0.35	NA	NA	0.82	disease	0.75	disease	0.69	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	-0.14	medium_impact	1.09	medium_impact	0.19	0.8	NA	NA	0.34	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4978	4978	T	C	MI.13828	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	509	170	L	S	tTa/tCa	0.03	0	0	probably_damaging	1	neutral	0.52	neutral	4.05	deleterious	-4.64	deleterious	-5.88	medium_impact	3.42	0.85	neutral	0.14	damaging	3.75	23.30	deleterious	0.02	0.35	NA	NA	0.83	disease	0.72	disease	0.68	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.88	deleterious	-3.54	low_impact	0.23	medium_impact	1.73	medium_impact	0.25	0.8	NA	NA	0.26	N	0.96	polymorphism	1	0.11	rs879210481	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4979	4979	A	T	MI.13829	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	510	170	L	F	ttA/ttT	7.4	0.95	0	probably_damaging	1	neutral	0.7	neutral	4.09	deleterious	-3.19	deleterious	-3.92	medium_impact	2.23	0.85	neutral	0.1	damaging	3.58	23.20	deleterious	0.08	0.35	NA	NA	0.78	disease	0.73	disease	0.68	disease	4	1	deleterious	0.35	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	0.41	medium_impact	0.73	medium_impact	0.57	0.8	NA	NA	0.43	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9176	9176	T	A	MI.1383	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	650	217	L	Q	cTa/cAa	-0.1	0	0.01	probably_damaging	1	deleterious	0	neutral	2.16	deleterious	-9.42	deleterious	-5.35	high_impact	4.57	0.41	damaging	0.45	neutral	4.13	23.80	deleterious	0.11	0.65	NA	NA	0.82	disease	0.79	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.82	high_impact	0.61	0.9	50	9.01	0.66	P	0.98	disease_causing	0.88	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4979	4979	A	C	MI.13830	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	510	170	L	F	ttA/ttC	7.4	0.95	0	probably_damaging	1	neutral	0.7	neutral	4.09	deleterious	-3.19	deleterious	-3.92	medium_impact	2.23	0.85	neutral	0.1	damaging	3.44	23.00	deleterious	0.08	0.35	NA	NA	0.78	disease	0.73	disease	0.68	disease	4	1	deleterious	0.35	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	0.41	medium_impact	0.73	medium_impact	0.57	0.8	NA	NA	0.43	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4980	4980	A	T	MI.13831	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	511	171	N	Y	Aac/Tac	-5.27	0	0	probably_damaging	1	neutral	0.75	neutral	4.53	neutral	-2	deleterious	-7.84	high_impact	3.75	0.68	neutral	0.05	damaging	3.68	23.30	deleterious	0.07	0.35	0.78	disease	0.91	disease	0.74	disease	0.7	disease	4	1	deleterious	0.38	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	0.47	medium_impact	2.01	high_impact	0.19	0.8	NA	NA	0.32	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4980	4980	A	C	MI.13832	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	511	171	N	H	Aac/Cac	-5.27	0	0	probably_damaging	1	neutral	0.48	neutral	4.52	neutral	-2.52	deleterious	-4.9	high_impact	3.75	0.74	neutral	0.04	damaging	3.05	22.40	deleterious	0.2	0.45	0.79	disease	0.84	disease	0.74	disease	0.69	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.19	medium_impact	2.01	high_impact	0.20	0.8	NA	NA	0.29	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4980	4980	A	G	MI.13833	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	511	171	N	D	Aac/Gac	-5.27	0	0	probably_damaging	1	neutral	0.64	neutral	4.55	neutral	-1.56	deleterious	-4.9	high_impact	3.75	0.71	neutral	0.04	damaging	3.78	23.40	deleterious	0.27	0.45	0.64	disease	0.82	disease	0.65	disease	0.67	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.35	medium_impact	2.01	high_impact	0.25	0.8	NA	NA	0.25	N	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4981	4981	A	G	MI.13834	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	512	171	N	S	aAc/aGc	8.55	1	0	probably_damaging	1	neutral	0.93	neutral	4.65	neutral	0.01	deleterious	-4.9	medium_impact	2.9	0.73	neutral	0.08	damaging	2.95	22.10	deleterious	0.28	0.45	0.62	disease	0.83	disease	0.61	disease	0.66	disease	3	1	deleterious	0.47	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	0.83	medium_impact	1.3	medium_impact	0.21	0.8	NA	NA	0.46	N	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4981	4981	A	T	MI.13835	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	512	171	N	I	aAc/aTc	8.55	1	0	probably_damaging	1	neutral	0.45	neutral	4.53	neutral	-2.35	deleterious	-8.82	medium_impact	2.94	0.74	neutral	0.05	damaging	3.80	23.40	deleterious	0.09	0.4	0.83	disease	0.93	disease	0.68	disease	0.66	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	0.16	medium_impact	1.33	medium_impact	0.13	0.8	NA	NA	0.54	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4981	4981	A	C	MI.13836	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	512	171	N	T	aAc/aCc	8.55	1	0	probably_damaging	1	neutral	0.77	neutral	4.64	neutral	-0.02	deleterious	-5.88	medium_impact	2.86	0.74	neutral	0.05	damaging	3.31	22.90	deleterious	0.18	0.45	0.63	disease	0.85	disease	0.68	disease	0.7	disease	4	1	deleterious	0.39	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	0.5	medium_impact	1.26	medium_impact	0.20	0.8	NA	NA	0.48	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4982	4982	C	A	MI.13837	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	513	171	N	K	aaC/aaA	8.55	1	0	probably_damaging	1	neutral	0.96	neutral	4.61	neutral	-0.34	deleterious	-5.88	high_impact	3.54	0.73	neutral	0.04	damaging	4.45	24.20	deleterious	0.2	0.45	0.52	disease	0.89	disease	0.71	disease	0.71	disease	4	1	deleterious	0.48	deleterious	2	deleterious	0.85	deleterious	-3.54	low_impact	0.98	medium_impact	1.84	medium_impact	0.35	0.8	NA	NA	0.5	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4982	4982	C	G	MI.13838	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	513	171	N	K	aaC/aaG	8.55	1	0	probably_damaging	1	neutral	0.96	neutral	4.61	neutral	-0.34	deleterious	-5.88	high_impact	3.54	0.73	neutral	0.04	damaging	4.01	23.60	deleterious	0.2	0.45	0.52	disease	0.89	disease	0.71	disease	0.71	disease	4	1	deleterious	0.48	deleterious	2	deleterious	0.85	deleterious	-3.54	low_impact	0.98	medium_impact	1.84	medium_impact	0.35	0.8	NA	NA	0.49	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4983	4983	C	G	MI.13839	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	514	172	Q	E	Caa/Gaa	-0.2	0.71	0	probably_damaging	0.99	neutral	0.27	neutral	4.15	deleterious	-4.12	deleterious	-2.93	medium_impact	2.8	0.82	neutral	0.42	neutral	3.06	22.40	deleterious	0.12	0.4	0.47	neutral	0.81	disease	0.78	disease	0.7	disease	4	0.99	deleterious	0.14	neutral	1	deleterious	0.85	deleterious	-2.62	low_impact	-0.03	medium_impact	1.21	medium_impact	0.34	0.8	NA	NA	0.36	N	0.90	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9176	9176	T	C	MI.1384	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	650	217	L	P	cTa/cCa	-0.1	0	0.01	probably_damaging	1	deleterious	0	neutral	2.16	deleterious	-9.53	deleterious	-6.26	high_impact	4.22	0.06	damaging	0.44	neutral	4.00	23.60	deleterious	0.12	0.65	NA	NA	0.8	disease	0.84	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.6	low_impact	-1.4	low_impact	2.52	high_impact	0.54	0.9	50	9.01	0.92	P	1.00	disease_causing_automatic	1	0.42	rs199476135	Pathogenic	Leigh_syndrome|Striatonigral_degeneration,_infantile,_mitochondrial	24683	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1839022,OMIM:500003	.	.	.	.	T9176C	FBSN / Leigh Disease	+	+	Cfrm	18	P	P	P	damaging
chrM	4983	4983	C	A	MI.13840	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	514	172	Q	K	Caa/Aaa	-0.2	0.71	0	probably_damaging	0.99	neutral	0.31	neutral	4.11	deleterious	-4.04	deleterious	-3.91	high_impact	3.77	0.79	neutral	0.38	neutral	4.05	23.70	deleterious	0.07	0.35	0.59	disease	0.9	disease	0.82	disease	0.73	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-2.62	low_impact	0.02	medium_impact	2.03	high_impact	0.41	0.8	NA	NA	0.45	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4984	4984	A	G	MI.13841	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	515	172	Q	R	cAa/cGa	5.55	1	0	probably_damaging	0.99	neutral	0.37	neutral	4.07	deleterious	-4.7	deleterious	-3.91	high_impact	4.12	0.78	neutral	0.39	neutral	3.49	23.10	deleterious	0.08	0.35	0.69	disease	0.89	disease	0.83	disease	0.74	disease	5	0.99	deleterious	0.19	neutral	2	deleterious	0.89	deleterious	-2.62	low_impact	0.08	medium_impact	2.32	high_impact	0.30	0.8	NA	NA	0.7	P	0.87	polymorphism	0.99	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4984	4984	A	T	MI.13842	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	515	172	Q	L	cAa/cTa	5.55	1	0	probably_damaging	1	neutral	0.69	neutral	4.08	deleterious	-5.99	deleterious	-6.85	medium_impact	3.42	0.76	neutral	0.42	neutral	3.82	23.40	deleterious	0.03	0.35	0.68	disease	0.91	disease	0.76	disease	0.72	disease	4	1	deleterious	0.35	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	0.4	medium_impact	1.73	medium_impact	0.25	0.8	NA	NA	0.56	N	0.96	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4984	4984	A	C	MI.13843	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	515	172	Q	P	cAa/cCa	5.55	1	0	probably_damaging	1	neutral	0.2	neutral	4.03	deleterious	-6.63	deleterious	-5.87	high_impact	4.12	0.87	neutral	0.45	neutral	3.34	22.90	deleterious	0.02	0.35	0.84	disease	0.91	disease	0.84	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.54	low_impact	-0.13	medium_impact	2.32	high_impact	0.15	0.8	NA	NA	0.7	P	0.96	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4985	4985	A	T	MI.13844	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	516	172	Q	H	caA/caT	5.55	1	0	probably_damaging	1	neutral	0.54	neutral	4.04	deleterious	-6.17	deleterious	-4.89	medium_impact	2.96	0.81	neutral	0.34	neutral	3.57	23.20	deleterious	0.06	0.35	0.82	disease	0.84	disease	0.84	disease	0.69	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	0.25	medium_impact	1.35	medium_impact	0.51	0.8	NA	NA	0.57	P	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4985	4985	A	C	MI.13845	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	516	172	Q	H	caA/caC	5.55	1	0	probably_damaging	1	neutral	0.54	neutral	4.04	deleterious	-6.17	deleterious	-4.89	medium_impact	2.96	0.81	neutral	0.34	neutral	3.35	22.90	deleterious	0.06	0.35	0.82	disease	0.84	disease	0.84	disease	0.69	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	0.25	medium_impact	1.35	medium_impact	0.51	0.8	NA	NA	0.57	P	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4986	4986	A	T	MI.13846	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	517	173	T	S	Acc/Tcc	3.02	1	0	probably_damaging	1	neutral	0.45	neutral	4.54	neutral	-1.66	deleterious	-3.91	medium_impact	2.25	0.92	neutral	0.15	damaging	3.19	22.70	deleterious	0.36	0.5	0.46	neutral	0.67	disease	0.48	neutral	0.4	neutral	2	1	deleterious	0.23	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.16	medium_impact	0.75	medium_impact	0.48	0.8	0.29	10.09	0.51	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4986	4986	A	C	MI.13847	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	517	173	T	P	Acc/Ccc	3.02	1	0	probably_damaging	1	neutral	0.2	neutral	4.4	deleterious	-3.85	deleterious	-5.87	medium_impact	2.81	0.86	neutral	0.24	damaging	3.42	23.00	deleterious	0.04	0.35	0.76	disease	0.77	disease	0.63	disease	0.37	neutral	3	1	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.13	medium_impact	1.22	medium_impact	0.25	0.8	0.29	10.09	0.46	N	0.97	polymorphism	1	0.09	.	.	.	.	.	oral cancer	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4986	4986	A	G	MI.13848	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	517	173	T	A	Acc/Gcc	3.02	1	0	probably_damaging	1	neutral	0.52	neutral	4.46	neutral	-2.29	deleterious	-4.89	high_impact	3.62	0.88	neutral	0.14	damaging	3.39	23.00	deleterious	0.14	0.4	0.48	neutral	0.65	disease	0.6	disease	0.64	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.23	medium_impact	1.9	medium_impact	0.35	0.8	0.29	10.09	0.47	N	0.69	polymorphism	1	0.09	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4987	4987	C	A	MI.13849	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	518	173	T	N	aCc/aAc	6.71	1	0	probably_damaging	1	neutral	0.31	neutral	4.49	neutral	-1.27	deleterious	-4.89	medium_impact	2.61	0.9	neutral	0.14	damaging	3.82	23.40	deleterious	0.29	0.45	0.3	neutral	0.83	disease	0.6	disease	0.67	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.02	medium_impact	1.05	medium_impact	0.55	0.8	0.29	10.09	0.58	P	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9176	9176	T	G	MI.1385	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	650	217	L	R	cTa/cGa	-0.1	0	0.01	probably_damaging	1	deleterious	0	neutral	2.16	deleterious	-9.28	deleterious	-5.36	high_impact	4.57	0.18	damaging	0.36	neutral	4.29	24.00	deleterious	0.11	0.65	NA	NA	0.88	disease	0.85	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.6	low_impact	-1.4	low_impact	2.82	high_impact	0.37	0.9	50	9.01	0.9	P	0.99	disease_causing_automatic	0.9	0.41	rs199476135	Pathogenic	Leigh_syndrome	24689	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	.	.	T9176G	Leigh Disease / Spastic Paraplegia	-	+	Cfrm	4	P	P	P	damaging
chrM	4987	4987	C	G	MI.13850	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	518	173	T	S	aCc/aGc	6.71	1	0	probably_damaging	1	neutral	0.45	neutral	4.54	neutral	-1.66	deleterious	-3.91	medium_impact	2.25	0.92	neutral	0.15	damaging	3.54	23.10	deleterious	0.36	0.5	0.46	neutral	0.67	disease	0.48	neutral	0.4	neutral	2	1	deleterious	0.23	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.16	medium_impact	0.75	medium_impact	0.48	0.8	0.29	10.09	0.58	P	0.89	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4987	4987	C	T	MI.13851	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	518	173	T	I	aCc/aTc	6.71	1	0	probably_damaging	1	neutral	0.44	neutral	4.53	deleterious	-3.46	deleterious	-5.87	medium_impact	2.77	0.88	neutral	0.13	damaging	3.94	23.50	deleterious	0.12	0.4	0.22	neutral	0.83	disease	0.51	disease	0.66	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.15	medium_impact	1.19	medium_impact	0.45	0.8	0.29	10.09	0.5	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4989	4989	C	A	MI.13852	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	520	174	Q	K	Cag/Aag	-10.56	0	0	probably_damaging	0.99	neutral	0.29	neutral	4.73	neutral	0.6	deleterious	-3.91	medium_impact	3.27	0.83	neutral	0.11	damaging	4.02	23.60	deleterious	0.22	0.45	0.58	disease	0.85	disease	0.69	disease	0.68	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.85	deleterious	-2.62	low_impact	-0.01	medium_impact	1.61	medium_impact	0.42	0.8	0.58	6.75	0.28	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4989	4989	C	G	MI.13853	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	520	174	Q	E	Cag/Gag	-10.56	0	0	probably_damaging	0.99	neutral	0.27	neutral	4.62	neutral	0.81	deleterious	-2.93	medium_impact	3.12	0.85	neutral	0.12	damaging	3.11	22.50	deleterious	0.3	0.45	0.61	disease	0.77	disease	0.67	disease	0.66	disease	3	0.99	deleterious	0.14	neutral	1	deleterious	0.84	deleterious	-2.62	low_impact	-0.03	medium_impact	1.48	medium_impact	0.33	0.8	0.58	6.75	0.28	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4990	4990	A	T	MI.13854	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	521	174	Q	L	cAg/cTg	5.55	1	0	probably_damaging	1	neutral	0.68	neutral	4.55	neutral	-1.38	deleterious	-6.84	medium_impact	2.38	0.91	neutral	0.13	damaging	3.90	23.50	deleterious	0.05	0.35	0.29	neutral	0.88	disease	0.64	disease	0.67	disease	3	1	deleterious	0.34	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.39	medium_impact	0.86	medium_impact	0.35	0.8	0.58	6.75	0.49	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4990	4990	A	G	MI.13855	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	521	174	Q	R	cAg/cGg	5.55	1	0	probably_damaging	0.99	neutral	0.35	neutral	4.58	neutral	0.46	deleterious	-3.91	medium_impact	3.12	0.83	neutral	0.12	damaging	3.55	23.10	deleterious	0.21	0.45	0.62	disease	0.84	disease	0.71	disease	0.69	disease	4	0.99	deleterious	0.18	neutral	1	deleterious	0.85	deleterious	-2.62	low_impact	0.06	medium_impact	1.48	medium_impact	0.29	0.8	0.58	6.75	0.57	P	0.64	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4990	4990	A	C	MI.13856	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	521	174	Q	P	cAg/cCg	5.55	1	0	probably_damaging	1	neutral	0.2	neutral	4.54	neutral	-1.81	deleterious	-5.87	medium_impact	3.48	0.77	neutral	0.11	damaging	3.45	23.00	deleterious	0.03	0.35	0.73	disease	0.89	disease	0.76	disease	0.69	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	-0.13	medium_impact	1.79	medium_impact	0.33	0.8	0.58	6.75	0.6	P	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4991	4991	G	T	MI.13857	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	522	174	Q	H	caG/caT	6.71	1	0.02	probably_damaging	1	neutral	0.54	neutral	4.55	neutral	-1.05	deleterious	-4.89	medium_impact	2.23	0.92	neutral	0.66	neutral	2.41	18.87	deleterious	0.25	0.45	0.72	disease	0.74	disease	0.49	neutral	0.2	neutral	6	1	deleterious	0.27	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.25	medium_impact	0.73	medium_impact	0.61	0.8	0.58	6.75	0.56	P	0.51	polymorphism	1	0.07	rs386828958	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4991	4991	G	C	MI.13858	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	522	174	Q	H	caG/caC	6.71	1	0.02	probably_damaging	1	neutral	0.54	neutral	4.55	neutral	-1.05	deleterious	-4.89	medium_impact	2.23	0.92	neutral	0.66	neutral	2.29	18.11	deleterious	0.25	0.45	0.72	disease	0.74	disease	0.49	neutral	0.2	neutral	6	1	deleterious	0.27	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.25	medium_impact	0.73	medium_impact	0.61	0.8	0.58	6.75	0.56	P	0.51	polymorphism	1	0.07	rs386828958	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	4992	4992	C	A	MI.13859	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	523	175	L	M	Cta/Ata	1.64	0.79	0	probably_damaging	1	neutral	0.43	neutral	4.45	neutral	-1.75	neutral	-1.94	low_impact	1.74	0.89	neutral	0.79	neutral	2.86	21.70	deleterious	0.28	0.45	0.43	neutral	0.37	neutral	0.3	neutral	0.47	neutral	1	1	deleterious	0.22	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.14	medium_impact	0.32	medium_impact	0.65	0.8	1.44	7.27	0.4	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9178	9178	G	A	MI.1386	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	652	218	V	M	Gta/Ata	-1.26	0	0	probably_damaging	1	neutral	0.05	neutral	4.31	neutral	-1.11	neutral	-1.45	low_impact	0.96	0.82	neutral	0.51	neutral	3.80	23.40	deleterious	0.43	0.65	NA	NA	0.39	neutral	0.36	neutral	0.17	neutral	7	1	deleterious	0.03	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	-0.43	medium_impact	-0.28	medium_impact	0.94	0.95	20.35	9.08	0.38	N	0.82	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4992	4992	C	G	MI.13860	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	523	175	L	V	Cta/Gta	1.64	0.79	0	probably_damaging	1	neutral	0.53	neutral	4.5	neutral	-0.58	deleterious	-2.91	medium_impact	2.02	0.91	neutral	0.26	damaging	3.39	23.00	deleterious	0.24	0.45	0.5	neutral	0.47	neutral	0.47	neutral	0.34	neutral	3	1	deleterious	0.27	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.24	medium_impact	0.56	medium_impact	0.48	0.8	1.44	7.27	0.3	N	0.44	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4993	4993	T	C	MI.13861	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	524	175	L	P	cTa/cCa	-0.66	0	0	probably_damaging	1	neutral	0.19	neutral	4.34	deleterious	-4.82	deleterious	-6.82	high_impact	3.81	0.83	neutral	0.1	damaging	3.93	23.50	deleterious	0.03	0.35	0.8	disease	0.88	disease	0.71	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	-0.14	medium_impact	2.06	high_impact	0.22	0.8	1.44	7.27	0.31	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4993	4993	T	G	MI.13862	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	524	175	L	R	cTa/cGa	-0.66	0	0	probably_damaging	1	neutral	0.48	neutral	4.35	deleterious	-4.75	deleterious	-5.84	high_impact	3.81	0.82	neutral	0.1	damaging	4.22	23.90	deleterious	0.03	0.35	0.68	disease	0.84	disease	0.71	disease	0.7	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.19	medium_impact	2.06	high_impact	0.12	0.8	1.44	7.27	0.28	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4993	4993	T	A	MI.13863	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	524	175	L	Q	cTa/cAa	-0.66	0	0	probably_damaging	1	neutral	0.26	neutral	4.34	deleterious	-4.88	deleterious	-5.84	high_impact	3.81	0.87	neutral	0.13	damaging	4.10	23.70	deleterious	0.04	0.35	0.67	disease	0.75	disease	0.6	disease	0.64	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.04	medium_impact	2.06	high_impact	0.20	0.8	1.44	7.27	0.34	N	0.94	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4995	4995	C	A	MI.13864	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	526	176	R	S	Cgc/Agc	-1.58	0	0	possibly_damaging	0.76	neutral	0.46	neutral	4.38	deleterious	-3.93	deleterious	-5.78	medium_impact	3.25	0.73	neutral	0.44	neutral	2.93	22.00	deleterious	0.03	0.35	0.57	disease	0.9	disease	0.66	disease	0.7	disease	4	0.75	neutral	0.35	neutral	0	NA	0.82	deleterious	-1.26	low_impact	0.17	medium_impact	1.59	medium_impact	0.11	0.8	NA	NA	0.31	N	0.81	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4995	4995	C	T	MI.13865	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	526	176	R	C	Cgc/Tgc	-1.58	0	0	probably_damaging	0.97	neutral	0.17	neutral	4.36	deleterious	-6.79	deleterious	-7.7	high_impact	4.05	0.87	neutral	0.25	damaging	4.95	25.00	deleterious	0.05	0.35	0.85	disease	0.92	disease	0.7	disease	0.64	disease	3	0.98	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-2.18	low_impact	-0.17	medium_impact	2.27	high_impact	0.63	0.8	NA	NA	0.42	N	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4995	4995	C	G	MI.13866	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	526	176	R	G	Cgc/Ggc	-1.58	0	0	possibly_damaging	0.81	neutral	0.33	neutral	4.37	deleterious	-4.62	deleterious	-6.74	high_impact	4.05	0.76	neutral	0.42	neutral	2.56	19.85	deleterious	0.03	0.35	0.56	disease	0.84	disease	0.7	disease	0.7	disease	4	0.84	neutral	0.26	neutral	1	deleterious	0.78	deleterious	-1.37	low_impact	0.04	medium_impact	2.27	high_impact	0.12	0.8	NA	NA	0.37	N	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4996	4996	G	T	MI.13867	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	527	176	R	L	cGc/cTc	3.48	0.99	0	possibly_damaging	0.81	neutral	0.7	neutral	4.38	deleterious	-4.16	deleterious	-6.74	medium_impact	3.37	0.7	neutral	0.32	neutral	2.75	21.10	deleterious	0.03	0.35	0.27	neutral	0.94	disease	0.66	disease	0.76	disease	5	0.77	neutral	0.45	neutral	0	NA	0.79	deleterious	-1.37	low_impact	0.41	medium_impact	1.69	medium_impact	0.04	0.8	NA	NA	0.46	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4996	4996	G	A	MI.13868	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	527	176	R	H	cGc/cAc	3.48	0.99	0	benign	0.08	neutral	0.54	neutral	4.38	deleterious	-4.13	deleterious	-4.82	high_impact	3.71	0.68	neutral	0.2	damaging	2.54	19.70	deleterious	0.13	0.4	0.8	disease	0.88	disease	0.58	disease	0.65	disease	3	0.39	neutral	0.73	deleterious	-2	neutral	0.44	deleterious	0.17	medium_impact	0.25	medium_impact	1.98	medium_impact	0.57	0.8	NA	NA	0.52	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4996	4996	G	C	MI.13869	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	527	176	R	P	cGc/cCc	3.48	0.99	0	probably_damaging	0.95	neutral	0.2	neutral	4.37	deleterious	-5.04	deleterious	-6.75	high_impact	3.71	0.71	neutral	0.29	neutral	4.13	23.80	deleterious	0.02	0.35	0.82	disease	0.93	disease	0.77	disease	0.67	disease	3	0.97	neutral	0.13	neutral	2	deleterious	0.90	deleterious	-1.97	low_impact	-0.13	medium_impact	1.98	medium_impact	0.07	0.8	NA	NA	0.58	P	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9178	9178	G	C	MI.1387	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	652	218	V	L	Gta/Cta	-1.26	0	0	probably_damaging	0.98	neutral	1	neutral	4.47	neutral	0.14	neutral	-0.8	neutral_impact	-0.9	0.7	neutral	0.58	neutral	0.91	10.13	neutral	0.38	0.65	NA	NA	0.14	neutral	0.14	neutral	0.21	neutral	6	0.98	neutral	0.51	deleterious	-2	neutral	0.67	deleterious	-2.36	low_impact	1.98	high_impact	-1.87	low_impact	0.61	0.9	20.35	9.08	0.31	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	4998	4998	A	G	MI.13870	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	529	177	K	E	Aaa/Gaa	0.49	0.98	0	probably_damaging	1	neutral	0.27	neutral	4.39	neutral	-1.62	deleterious	-3.84	high_impact	3.69	0.78	neutral	0.09	damaging	4.05	23.70	deleterious	0.13	0.4	0.41	neutral	0.89	disease	0.72	disease	0.7	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.03	medium_impact	1.96	medium_impact	0.43	0.8	NA	NA	0.46	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4998	4998	A	C	MI.13871	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	529	177	K	Q	Aaa/Caa	0.49	0.98	0	probably_damaging	1	neutral	0.29	neutral	4.35	neutral	-1.92	deleterious	-3.84	medium_impact	3.23	0.72	neutral	0.08	damaging	3.50	23.10	deleterious	0.29	0.45	0.45	neutral	0.86	disease	0.7	disease	0.71	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.01	medium_impact	1.57	medium_impact	0.43	0.8	NA	NA	0.47	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4999	4999	A	C	MI.13872	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	530	177	K	T	aAa/aCa	8.55	1	0	probably_damaging	1	neutral	0.39	neutral	4.34	neutral	-2.45	deleterious	-5.76	medium_impact	2.88	0.74	neutral	0.09	damaging	3.63	23.20	deleterious	0.06	0.35	0.26	neutral	0.87	disease	0.72	disease	0.69	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.1	medium_impact	1.28	medium_impact	0.22	0.8	NA	NA	0.51	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	4999	4999	A	T	MI.13873	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	530	177	K	M	aAa/aTa	8.55	1	0	probably_damaging	1	neutral	0.22	neutral	4.32	deleterious	-4.05	deleterious	-5.76	medium_impact	3.06	0.75	neutral	0.07	damaging	3.99	23.60	deleterious	0.07	0.35	0.77	disease	0.87	disease	0.7	disease	0.69	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.1	medium_impact	1.43	medium_impact	0.19	0.8	NA	NA	0.56	P	0.45	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5000	5000	A	C	MI.13874	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	531	177	K	N	aaA/aaC	8.55	1	0	probably_damaging	1	neutral	0.31	neutral	4.38	neutral	-2.42	deleterious	-4.8	high_impact	4.04	0.7	neutral	0.07	damaging	3.85	23.40	deleterious	0.27	0.45	0.24	neutral	0.86	disease	0.71	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.02	medium_impact	2.26	high_impact	0.55	0.8	NA	NA	0.62	P	0.69	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5000	5000	A	T	MI.13875	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	531	177	K	N	aaA/aaT	8.55	1	0	probably_damaging	1	neutral	0.31	neutral	4.38	neutral	-2.42	deleterious	-4.8	high_impact	4.04	0.7	neutral	0.07	damaging	3.91	23.50	deleterious	0.27	0.45	0.24	neutral	0.86	disease	0.71	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.02	medium_impact	2.26	high_impact	0.55	0.8	NA	NA	0.62	P	0.69	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5001	5001	A	T	MI.13876	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	532	178	I	F	Atc/Ttc	2.1	1	0	probably_damaging	0.97	neutral	0.45	neutral	4.46	neutral	-1.8	deleterious	-3.83	high_impact	3.88	0.86	neutral	0.46	neutral	3.60	23.20	deleterious	0.06	0.35	0.68	disease	0.85	disease	0.63	disease	0.68	disease	4	0.97	neutral	0.24	neutral	2	deleterious	0.84	deleterious	-2.18	low_impact	0.16	medium_impact	2.12	high_impact	0.54	0.8	0.86	7.97	0.52	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5001	5001	A	G	MI.13877	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	532	178	I	V	Atc/Gtc	2.1	1	0	possibly_damaging	0.8	neutral	0.32	neutral	4.67	neutral	0.05	neutral	-0.95	medium_impact	2.29	0.91	neutral	0.72	neutral	2.88	21.80	deleterious	0.36	0.5	0.5	neutral	0.46	neutral	0.44	neutral	0.31	neutral	4	0.83	neutral	0.26	neutral	0	NA	0.65	deleterious	-1.35	low_impact	0.03	medium_impact	0.78	medium_impact	0.60	0.8	0.86	7.97	0.56	P	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5001	5001	A	C	MI.13878	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	532	178	I	L	Atc/Ctc	2.1	1	0	possibly_damaging	0.8	neutral	0.78	neutral	4.77	neutral	1.86	neutral	-1.91	low_impact	1.28	0.85	neutral	0.55	neutral	3.60	23.20	deleterious	0.21	0.45	0.42	neutral	0.7	disease	0.39	neutral	0.17	neutral	7	0.76	neutral	0.49	deleterious	-3	neutral	0.71	deleterious	-1.35	low_impact	0.51	medium_impact	-0.07	medium_impact	0.36	0.8	0.86	7.97	0.38	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5002	5002	T	A	MI.13879	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	533	178	I	N	aTc/aAc	3.25	1	0	probably_damaging	0.95	neutral	0.2	neutral	4.41	deleterious	-3.84	deleterious	-6.68	high_impact	3.88	0.92	neutral	0.51	neutral	4.63	24.50	deleterious	0.06	0.35	0.5	disease	0.89	disease	0.61	disease	0.68	disease	4	0.97	neutral	0.13	neutral	2	deleterious	0.81	deleterious	-1.97	low_impact	-0.13	medium_impact	2.12	high_impact	0.14	0.8	0.86	7.97	0.6	P	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9178	9178	G	T	MI.1388	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	652	218	V	L	Gta/Tta	-1.26	0	0	probably_damaging	0.98	neutral	1	neutral	4.47	neutral	0.14	neutral	-0.8	neutral_impact	-0.9	0.7	neutral	0.58	neutral	1.07	11.05	neutral	0.38	0.65	NA	NA	0.14	neutral	0.14	neutral	0.21	neutral	6	0.98	neutral	0.51	deleterious	-2	neutral	0.67	deleterious	-2.36	low_impact	1.98	high_impact	-1.87	low_impact	0.61	0.9	20.35	9.08	0.31	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5002	5002	T	G	MI.13880	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	533	178	I	S	aTc/aGc	3.25	1	0	benign	0.34	neutral	0.64	neutral	4.46	neutral	-2.55	deleterious	-5.72	high_impact	3.88	0.88	neutral	0.58	neutral	4.29	24.00	deleterious	0.03	0.35	0.57	disease	0.89	disease	0.61	disease	0.68	disease	4	0.29	neutral	0.65	deleterious	-2	neutral	0.53	deleterious	-0.53	medium_impact	0.35	medium_impact	2.12	high_impact	0.12	0.8	0.86	7.97	0.5	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5002	5002	T	C	MI.13881	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	533	178	I	T	aTc/aCc	3.25	1	0	possibly_damaging	0.77	neutral	0.2	neutral	4.45	neutral	-2.07	deleterious	-4.76	medium_impact	2.99	0.94	neutral	0.49	neutral	3.44	23.00	deleterious	0.05	0.35	0.5	disease	0.83	disease	0.61	disease	0.65	disease	3	0.87	neutral	0.22	neutral	0	NA	0.75	deleterious	-1.28	low_impact	-0.13	medium_impact	1.37	medium_impact	0.23	0.8	0.86	7.97	0.58	P	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5003	5003	C	G	MI.13882	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	534	178	I	M	atC/atG	5.78	1	0	probably_damaging	0.98	neutral	0.32	neutral	4.45	neutral	0.86	deleterious	-2.87	medium_impact	2.02	0.91	neutral	0.69	neutral	3.36	22.90	deleterious	0.16	0.45	0.68	disease	0.7	disease	0.41	neutral	0.21	neutral	6	0.98	deleterious	0.17	neutral	1	deleterious	0.76	deleterious	-2.34	low_impact	0.03	medium_impact	0.56	medium_impact	0.57	0.8	0.86	7.97	0.58	P	0.45	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5003	5003	C	A	MI.13883	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	534	178	I	M	atC/atA	5.78	1	0	probably_damaging	0.98	neutral	0.32	neutral	4.45	neutral	0.86	deleterious	-2.87	medium_impact	2.02	0.91	neutral	0.69	neutral	3.78	23.40	deleterious	0.16	0.45	0.68	disease	0.7	disease	0.41	neutral	0.21	neutral	6	0.98	deleterious	0.17	neutral	1	deleterious	0.76	deleterious	-2.34	low_impact	0.03	medium_impact	0.56	medium_impact	0.57	0.8	0.86	7.97	0.58	P	0.45	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5004	5004	T	A	MI.13884	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	535	179	L	M	Tta/Ata	-4.11	0	0.03	possibly_damaging	0.46	neutral	0.49	neutral	4.25	deleterious	-4.14	neutral	0.81	neutral_impact	0.1	0.93	neutral	0.92	neutral	0.85	9.74	deleterious	0.15	0.4	NA	NA	0.08	neutral	0.36	neutral	0.18	neutral	6	0.48	neutral	0.52	deleterious	-3	neutral	0.56	deleterious	-0.73	medium_impact	0.2	medium_impact	-1.06	low_impact	0.48	0.8	NA	NA	0.41	N	0.13	polymorphism	1	0.01	rs41419549	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5004	5004	T	G	MI.13885	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	535	179	L	V	Tta/Gta	-4.11	0	0.03	possibly_damaging	0.79	neutral	0.44	neutral	4.35	deleterious	-3.68	neutral	-1.79	medium_impact	2.73	0.9	neutral	0.65	neutral	3.42	23.00	deleterious	0.1	0.4	NA	NA	0.68	disease	0.69	disease	0.67	disease	3	0.79	neutral	0.33	neutral	0	NA	0.75	deleterious	-1.32	low_impact	0.15	medium_impact	1.15	medium_impact	0.44	0.8	NA	NA	0.34	N	0.31	polymorphism	1	0.03	rs41419549	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	5005	5005	T	C	MI.13886	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	536	179	L	S	tTa/tCa	-4.35	0	0	probably_damaging	0.95	neutral	0.68	neutral	4.13	deleterious	-7.07	deleterious	-4.13	medium_impact	2.98	0.81	neutral	0.56	neutral	3.74	23.30	deleterious	0.02	0.35	NA	NA	0.81	disease	0.7	disease	0.69	disease	4	0.95	neutral	0.37	neutral	1	deleterious	0.84	deleterious	-1.97	low_impact	0.39	medium_impact	1.36	medium_impact	0.28	0.8	NA	NA	0.25	N	0.78	polymorphism	1	0.29	rs879008075	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	5005	5005	T	G	MI.13887	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	536	179	L	W	tTa/tGa	-4.35	0	0	probably_damaging	0.99	neutral	0.17	neutral	4.11	deleterious	-7.9	deleterious	-4.13	high_impact	3.53	0.84	neutral	0.42	neutral	3.74	23.30	deleterious	0.02	0.35	NA	NA	0.84	disease	0.72	disease	0.72	disease	4	0.99	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-2.62	low_impact	-0.17	medium_impact	1.83	medium_impact	0.21	0.8	NA	NA	0.4	N	0.84	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5006	5006	A	T	MI.13888	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	537	179	L	F	ttA/ttT	7.4	1	0	probably_damaging	0.95	neutral	0.62	neutral	4.14	deleterious	-4.38	deleterious	-2.75	medium_impact	2.43	0.84	neutral	0.52	neutral	3.59	23.20	deleterious	0.06	0.35	NA	NA	0.77	disease	0.69	disease	0.68	disease	4	0.95	neutral	0.34	neutral	1	deleterious	0.82	deleterious	-1.97	low_impact	0.33	medium_impact	0.9	medium_impact	0.37	0.8	NA	NA	0.51	N	0.45	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5006	5006	A	C	MI.13889	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	537	179	L	F	ttA/ttC	7.4	1	0	probably_damaging	0.95	neutral	0.62	neutral	4.14	deleterious	-4.38	deleterious	-2.75	medium_impact	2.43	0.84	neutral	0.52	neutral	3.48	23.10	deleterious	0.06	0.35	NA	NA	0.77	disease	0.69	disease	0.68	disease	4	0.95	neutral	0.34	neutral	1	deleterious	0.82	deleterious	-1.97	low_impact	0.33	medium_impact	0.9	medium_impact	0.37	0.8	NA	NA	0.5	N	0.45	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9179	9179	T	A	MI.1389	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	653	218	V	E	gTa/gAa	0.36	0.15	0	probably_damaging	1	deleterious	0.01	neutral	4.27	neutral	-1.46	deleterious	-4.78	medium_impact	2.86	0.77	neutral	0.43	neutral	4.85	24.80	deleterious	0.18	0.65	NA	NA	0.8	disease	0.64	disease	0.77	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	1.35	medium_impact	0.41	0.9	20.35	9.08	0.33	N	1.00	polymorphism	0.98	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5007	5007	G	T	MI.13890	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	538	180	A	S	Gca/Tca	0.49	0.99	0	possibly_damaging	0.79	neutral	0.44	neutral	2.93	deleterious	-5.79	deleterious	-2.88	medium_impact	2.86	0.85	neutral	0.57	neutral	3.71	23.30	deleterious	0.05	0.35	0.28	neutral	0.83	disease	0.67	disease	0.69	disease	4	0.79	neutral	0.33	neutral	0	NA	0.75	deleterious	-1.32	low_impact	0.15	medium_impact	1.26	medium_impact	0.55	0.8	NA	NA	0.45	N	0.57	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5007	5007	G	A	MI.13891	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	538	180	A	T	Gca/Aca	0.49	0.99	0	probably_damaging	0.95	neutral	0.38	neutral	2.92	deleterious	-7.84	deleterious	-3.87	medium_impact	2.27	0.82	neutral	0.4	neutral	4.23	23.90	deleterious	0.03	0.35	0.63	disease	0.86	disease	0.69	disease	0.71	disease	4	0.95	neutral	0.22	neutral	1	deleterious	0.83	deleterious	-1.97	low_impact	0.09	medium_impact	0.77	medium_impact	0.72	0.85	NA	NA	0.42	N	0.75	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5007	5007	G	C	MI.13892	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	538	180	A	P	Gca/Cca	0.49	0.99	0	probably_damaging	0.98	neutral	0.2	neutral	2.89	deleterious	-9.43	deleterious	-4.83	high_impact	4.05	0.76	neutral	0.41	neutral	3.83	23.40	deleterious	0.02	0.35	0.79	disease	0.89	disease	0.8	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-2.34	low_impact	-0.13	medium_impact	2.27	high_impact	0.51	0.8	NA	NA	0.54	P	0.94	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5008	5008	C	A	MI.13893	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	539	180	A	E	gCa/gAa	9.01	1	0	probably_damaging	0.97	neutral	0.26	neutral	2.89	deleterious	-10.66	deleterious	-4.83	high_impact	4.05	0.85	neutral	0.4	neutral	4.57	24.40	deleterious	0.02	0.35	0.41	neutral	0.9	disease	0.77	disease	0.72	disease	4	0.97	neutral	0.15	neutral	2	deleterious	0.83	deleterious	-2.18	low_impact	-0.04	medium_impact	2.27	high_impact	0.40	0.8	NA	NA	0.63	P	0.92	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5008	5008	C	T	MI.13894	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	539	180	A	V	gCa/gTa	9.01	1	0	probably_damaging	0.95	neutral	0.5	neutral	2.95	deleterious	-8.81	deleterious	-3.88	medium_impact	2.81	0.81	neutral	0.41	neutral	4.41	24.10	deleterious	0.03	0.35	0.75	disease	0.85	disease	0.69	disease	0.71	disease	4	0.94	neutral	0.28	neutral	1	deleterious	0.83	deleterious	-1.97	low_impact	0.21	medium_impact	1.22	medium_impact	0.69	0.85	NA	NA	0.54	N	0.80	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5008	5008	C	G	MI.13895	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	539	180	A	G	gCa/gGa	9.01	1	0	benign	0.1	neutral	0.33	neutral	2.99	deleterious	-6.08	deleterious	-3.79	medium_impact	2.31	0.83	neutral	0.67	neutral	3.87	23.50	deleterious	0.04	0.35	0.68	disease	0.77	disease	0.64	disease	0.57	disease	1	0.62	neutral	0.62	deleterious	-3	neutral	0.32	neutral	0.08	medium_impact	0.04	medium_impact	0.8	medium_impact	0.71	0.85	NA	NA	0.58	P	0.39	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5010	5010	T	A	MI.13896	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	541	181	Y	N	Tac/Aac	-6.65	0	0	probably_damaging	1	neutral	0.31	neutral	4.14	deleterious	-9.03	deleterious	-8.49	medium_impact	3.41	0.86	neutral	0.12	damaging	4.04	23.70	deleterious	0.03	0.35	0.44	neutral	0.88	disease	0.71	disease	0.74	disease	5	1	deleterious	0.16	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.02	medium_impact	1.73	medium_impact	0.11	0.8	NA	NA	0.37	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5010	5010	T	C	MI.13897	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	541	181	Y	H	Tac/Cac	-6.65	0	0	probably_damaging	1	neutral	0.54	neutral	4.14	deleterious	-7.6	deleterious	-4.74	high_impact	3.76	0.84	neutral	0.09	damaging	3.58	23.20	deleterious	0.04	0.35	0.62	disease	0.82	disease	0.8	disease	0.75	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.25	medium_impact	2.02	high_impact	0.20	0.8	NA	NA	0.33	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5010	5010	T	G	MI.13898	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	541	181	Y	D	Tac/Gac	-6.65	0	0	probably_damaging	1	neutral	0.2	neutral	4.14	deleterious	-11.05	deleterious	-9.41	high_impact	3.76	0.85	neutral	0.08	damaging	4.00	23.60	deleterious	0.02	0.35	0.37	neutral	0.92	disease	0.79	disease	0.75	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.13	medium_impact	2.02	high_impact	0.13	0.8	NA	NA	0.45	N	0.96	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5011	5011	A	G	MI.13899	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	542	181	Y	C	tAc/tGc	5.55	1	0	probably_damaging	1	neutral	0.18	neutral	4.17	deleterious	-10.89	deleterious	-8.46	medium_impact	2.79	0.78	neutral	0.09	damaging	3.37	22.90	deleterious	0.03	0.35	0.58	disease	0.9	disease	0.76	disease	0.77	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.16	medium_impact	1.2	medium_impact	0.13	0.8	NA	NA	0.46	N	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8591	8591	T	A	MI.139	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	65	22	L	Q	cTg/cAg	-5.89	0	0	possibly_damaging	0.8	deleterious	0.01	neutral	4.11	deleterious	-3.74	deleterious	-4.23	medium_impact	3.12	0.8	neutral	0.45	neutral	3.87	23.50	deleterious	0.18	0.65	0.85	disease	0.65	disease	0.58	disease	0.71	disease	4	0.99	deleterious	0.11	neutral	4	deleterious	0.71	deleterious	-1.33	low_impact	-0.84	medium_impact	1.58	medium_impact	0.61	0.9	25.22	20.33	0.33	N	0.52	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9179	9179	T	C	MI.1390	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	653	218	V	A	gTa/gCa	0.36	0.15	0	probably_damaging	0.99	neutral	0.11	neutral	4.35	neutral	0.68	deleterious	-2.98	low_impact	1.48	0.76	neutral	0.58	neutral	3.70	23.30	deleterious	0.33	0.65	NA	NA	0.34	neutral	0.49	neutral	0.17	neutral	7	0.99	deleterious	0.06	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	-0.22	medium_impact	0.17	medium_impact	0.52	0.9	20.35	9.08	0.4	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5011	5011	A	C	MI.13900	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	542	181	Y	S	tAc/tCc	5.55	1	0	probably_damaging	1	neutral	0.41	neutral	4.17	deleterious	-9.06	deleterious	-8.45	medium_impact	3.06	0.86	neutral	0.13	damaging	3.57	23.20	deleterious	0.03	0.35	0.42	neutral	0.86	disease	0.69	disease	0.71	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.12	medium_impact	1.43	medium_impact	0.15	0.8	NA	NA	0.47	N	0.96	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5011	5011	A	T	MI.13901	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	542	181	Y	F	tAc/tTc	5.55	1	0	probably_damaging	1	neutral	0.7	neutral	4.27	deleterious	-4.26	deleterious	-3.58	low_impact	0.89	0.89	neutral	0.65	neutral	2.08	16.71	deleterious	0.11	0.4	0.43	neutral	0.23	neutral	0.54	disease	0.43	neutral	1	1	deleterious	0.35	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	0.41	medium_impact	-0.4	medium_impact	0.35	0.8	NA	NA	0.58	P	0.80	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5013	5013	T	A	MI.13902	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	544	182	S	T	Tcc/Acc	-0.2	0.76	0	benign	0.22	neutral	0.39	neutral	2.47	deleterious	-7.09	deleterious	-2.85	high_impact	4.12	0.76	neutral	0.09	damaging	3.97	23.60	deleterious	0.05	0.35	0.4	neutral	0.75	disease	0.77	disease	0.7	disease	4	0.53	neutral	0.59	deleterious	-2	neutral	0.47	deleterious	-0.29	medium_impact	0.1	medium_impact	2.32	high_impact	0.40	0.8	NA	NA	0.43	N	0.71	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5013	5013	T	G	MI.13903	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	544	182	S	A	Tcc/Gcc	-0.2	0.76	0	possibly_damaging	0.67	neutral	0.51	neutral	2.51	deleterious	-6.22	deleterious	-2.86	high_impact	4.12	0.67	neutral	0.13	damaging	3.68	23.30	deleterious	0.05	0.35	0.56	disease	0.67	disease	0.75	disease	0.71	disease	4	0.64	neutral	0.42	neutral	1	deleterious	0.73	deleterious	-1.08	low_impact	0.22	medium_impact	2.32	high_impact	0.41	0.8	NA	NA	0.41	N	0.49	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5013	5013	T	C	MI.13904	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	544	182	S	P	Tcc/Ccc	-0.2	0.76	0	probably_damaging	0.97	neutral	0.2	neutral	2.45	deleterious	-8.54	deleterious	-4.77	high_impact	3.78	0.73	neutral	0.05	damaging	4.03	23.60	deleterious	0.02	0.35	0.67	disease	0.86	disease	0.85	disease	0.74	disease	5	0.98	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-2.18	low_impact	-0.13	medium_impact	2.04	high_impact	0.34	0.8	NA	NA	0.45	N	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5014	5014	C	T	MI.13905	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	545	182	S	F	tCc/tTc	7.4	1	0	probably_damaging	0.98	neutral	0.71	neutral	2.44	deleterious	-9.94	deleterious	-5.72	high_impact	3.78	0.7	neutral	0.04	damaging	4.27	24.00	deleterious	0.02	0.35	0.82	disease	0.89	disease	0.76	disease	0.71	disease	4	0.98	neutral	0.37	neutral	2	deleterious	0.87	deleterious	-2.34	low_impact	0.42	medium_impact	2.04	high_impact	0.19	0.8	NA	NA	0.56	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5014	5014	C	G	MI.13906	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	545	182	S	C	tCc/tGc	7.4	1	0	probably_damaging	0.99	neutral	0.18	neutral	2.49	deleterious	-6.66	deleterious	-4.77	high_impact	4.12	0.71	neutral	0.05	damaging	3.60	23.20	deleterious	0.02	0.35	0.9	disease	0.82	disease	0.75	disease	0.68	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.62	low_impact	-0.16	medium_impact	2.32	high_impact	0.36	0.8	NA	NA	0.63	P	1.00	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5014	5014	C	A	MI.13907	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	545	182	S	Y	tCc/tAc	7.4	1	0	probably_damaging	0.99	neutral	1	neutral	2.44	deleterious	-10.34	deleterious	-5.72	high_impact	4.12	0.71	neutral	0.06	damaging	4.10	23.70	deleterious	0.02	0.35	0.82	disease	0.89	disease	0.78	disease	0.72	disease	4	0.99	deleterious	0.51	deleterious	2	deleterious	0.87	deleterious	-2.62	low_impact	1.87	high_impact	2.32	high_impact	0.35	0.8	NA	NA	0.59	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5016	5016	T	G	MI.13908	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	547	183	S	A	Tca/Gca	-3.19	0	0	probably_damaging	1	neutral	0.51	neutral	3.97	deleterious	-3.71	deleterious	-2.87	high_impact	3.57	0.91	neutral	0.2	damaging	3.66	23.20	deleterious	0.06	0.35	0.51	disease	0.7	disease	0.76	disease	0.71	disease	4	0.99	deleterious	0.26	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.22	medium_impact	1.86	medium_impact	0.38	0.8	NA	NA	0.35	N	0.49	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5016	5016	T	C	MI.13909	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	547	183	S	P	Tca/Cca	-3.19	0	0	probably_damaging	1	neutral	0.2	neutral	3.91	deleterious	-6	deleterious	-4.78	high_impact	3.77	0.78	neutral	0.12	damaging	3.97	23.60	deleterious	0.02	0.35	0.6	disease	0.87	disease	0.84	disease	0.76	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.13	medium_impact	2.03	high_impact	0.27	0.8	NA	NA	0.41	N	0.99	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9179	9179	T	G	MI.1391	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	653	218	V	G	gTa/gGa	0.36	0.15	0	probably_damaging	1	deleterious	0	neutral	4.26	neutral	-2.12	deleterious	-5.67	medium_impact	2.86	0.76	neutral	0.54	neutral	3.90	23.50	deleterious	0.18	0.65	NA	NA	0.62	disease	0.53	disease	0.63	disease	3	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.6	low_impact	-1.4	low_impact	1.35	medium_impact	0.41	0.9	20.35	9.08	0.37	N	0.95	disease_causing	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5016	5016	T	A	MI.13910	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	547	183	S	T	Tca/Aca	-3.19	0	0	probably_damaging	1	neutral	0.39	neutral	4.51	neutral	-0.37	deleterious	-2.87	high_impact	3.77	0.82	neutral	0.12	damaging	3.79	23.40	deleterious	0.06	0.35	0.56	disease	0.77	disease	0.73	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.1	medium_impact	2.03	high_impact	0.54	0.8	NA	NA	0.29	N	0.71	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5017	5017	C	T	MI.13911	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	548	183	S	L	tCa/tTa	7.4	1	0	probably_damaging	1	neutral	0.67	neutral	3.91	deleterious	-6.25	deleterious	-5.73	high_impact	3.77	0.76	neutral	0.1	damaging	4.61	24.40	deleterious	0.02	0.35	0.23	neutral	0.9	disease	0.73	disease	0.7	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.38	medium_impact	2.03	high_impact	0.44	0.8	NA	NA	0.52	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5017	5017	C	G	MI.13912	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	548	183	S	W	tCa/tGa	7.4	1	0	probably_damaging	1	neutral	0.19	neutral	3.9	deleterious	-9.39	deleterious	-6.68	high_impact	4.12	0.85	neutral	0.11	damaging	4.33	24.00	deleterious	0.02	0.35	0.89	disease	0.93	disease	0.78	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.14	medium_impact	2.32	high_impact	0.12	0.8	NA	NA	0.63	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5019	5019	A	C	MI.13913	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	550	184	I	L	Att/Ctt	-2.27	0	0	probably_damaging	0.99	neutral	0.71	neutral	4.27	deleterious	-3.83	neutral	-1.91	medium_impact	2.88	0.88	neutral	0.16	damaging	3.77	23.40	deleterious	0.12	0.4	0.45	neutral	0.72	disease	0.7	disease	0.7	disease	4	0.99	deleterious	0.36	neutral	1	deleterious	0.77	deleterious	-2.62	low_impact	0.42	medium_impact	1.28	medium_impact	0.48	0.8	NA	NA	0.27	N	0.85	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5019	5019	A	G	MI.13914	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	550	184	I	V	Att/Gtt	-2.27	0	0	probably_damaging	0.99	neutral	0.39	neutral	4.34	neutral	-1.05	neutral	-0.92	medium_impact	2.52	0.94	neutral	0.19	damaging	3.01	22.30	deleterious	0.36	0.5	0.51	disease	0.57	disease	0.67	disease	0.55	disease	1	0.99	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-2.62	low_impact	0.1	medium_impact	0.98	medium_impact	0.44	0.8	NA	NA	0.36	N	0.73	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5019	5019	A	T	MI.13915	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	550	184	I	F	Att/Ttt	-2.27	0	0	probably_damaging	1	neutral	0.65	neutral	4.07	deleterious	-6.6	deleterious	-3.82	high_impact	3.54	0.86	neutral	0.13	damaging	3.98	23.60	deleterious	0.03	0.35	0.71	disease	0.83	disease	0.76	disease	0.74	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.36	medium_impact	1.84	medium_impact	0.47	0.8	NA	NA	0.28	N	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5020	5020	T	G	MI.13916	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	551	184	I	S	aTt/aGt	6.71	1	0	probably_damaging	1	neutral	0.46	neutral	4.08	deleterious	-6.56	deleterious	-5.72	high_impact	4.08	0.91	neutral	0.18	damaging	4.24	23.90	deleterious	0.01	0.35	0.63	disease	0.87	disease	0.7	disease	0.73	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.17	medium_impact	2.29	high_impact	0.16	0.8	NA	NA	0.62	P	0.95	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5020	5020	T	C	MI.13917	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	551	184	I	T	aTt/aCt	6.71	1	0	probably_damaging	1	neutral	0.31	neutral	4.08	deleterious	-5.93	deleterious	-4.75	medium_impact	3.04	0.87	neutral	0.2	damaging	3.43	23.00	deleterious	0.03	0.35	0.35	neutral	0.77	disease	0.68	disease	0.6	disease	2	1	deleterious	0.16	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.02	medium_impact	1.42	medium_impact	0.17	0.8	NA	NA	0.55	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5020	5020	T	A	MI.13918	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	551	184	I	N	aTt/aAt	6.71	1	0	probably_damaging	1	neutral	0.21	neutral	4.05	deleterious	-8.21	deleterious	-6.68	high_impact	3.73	0.9	neutral	0.14	damaging	4.50	24.30	deleterious	0.03	0.35	0.82	disease	0.85	disease	0.75	disease	0.75	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.11	medium_impact	2	medium_impact	0.24	0.8	NA	NA	0.63	P	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5021	5021	T	A	MI.13919	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	552	184	I	M	atT/atA	4.63	1	0.01	probably_damaging	1	neutral	0.29	neutral	4.14	deleterious	-5.01	deleterious	-2.85	medium_impact	2.98	0.95	neutral	0.17	damaging	3.72	23.30	deleterious	0.05	0.35	0.56	disease	0.74	disease	0.74	disease	0.71	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.01	medium_impact	1.36	medium_impact	0.48	0.8	NA	NA	0.58	P	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9181	9181	A	T	MI.1392	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	655	219	S	C	Agc/Tgc	-2.88	0	0.01	probably_damaging	1	neutral	0.07	neutral	4.36	neutral	-0.89	deleterious	-4.4	low_impact	1.62	0.8	neutral	0.42	neutral	3.52	23.10	deleterious	0.33	0.65	NA	NA	0.75	disease	0.67	disease	0.64	disease	3	1	deleterious	0.04	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	-0.34	medium_impact	0.29	medium_impact	0.80	0.9	48.23	7.68	0.28	N	0.99	polymorphism	0.62	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5021	5021	T	G	MI.13920	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	552	184	I	M	atT/atG	4.63	1	0.01	probably_damaging	1	neutral	0.29	neutral	4.14	deleterious	-5.01	deleterious	-2.85	medium_impact	2.98	0.95	neutral	0.17	damaging	3.42	23.00	deleterious	0.05	0.35	0.56	disease	0.74	disease	0.74	disease	0.71	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.01	medium_impact	1.36	medium_impact	0.48	0.8	NA	NA	0.58	P	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5022	5022	A	C	MI.13921	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	553	185	T	P	Acc/Ccc	-2.04	0	0	probably_damaging	1	neutral	0.2	neutral	4.56	neutral	-2.03	neutral	-1.76	low_impact	1.32	0.7	neutral	0.21	damaging	3.45	23.00	deleterious	0.04	0.35	0.3	neutral	0.92	disease	0.71	disease	0.77	disease	5	1	deleterious	0.1	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	-0.13	medium_impact	-0.03	medium_impact	0.40	0.8	2.02	8.22	0.28	N	0.78	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5022	5022	A	T	MI.13922	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	553	185	T	S	Acc/Tcc	-2.04	0	0	probably_damaging	1	neutral	0.41	neutral	4.89	neutral	3.13	neutral	0.16	neutral_impact	-0.84	0.85	neutral	0.91	neutral	2.09	16.77	deleterious	0.23	0.45	0.36	neutral	0.28	neutral	0.45	neutral	0.44	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.12	medium_impact	-1.85	low_impact	0.58	0.8	2.02	8.22	0.36	N	0.34	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5022	5022	A	G	MI.13923	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	553	185	T	A	Acc/Gcc	-2.04	0	0	probably_damaging	1	neutral	0.54	neutral	4.7	neutral	2.26	neutral	2.37	neutral_impact	-2.02	0.93	neutral	0.92	neutral	0.76	9.21	deleterious	0.16	0.45	0.22	neutral	0.16	neutral	0.35	neutral	0.23	neutral	5	1	deleterious	0.27	neutral	-2	neutral	0.64	deleterious	-3.54	low_impact	0.25	medium_impact	-2.85	low_impact	0.44	0.8	2.02	8.22	0.3	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5023	5023	C	T	MI.13924	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	554	185	T	I	aCc/aTc	0.95	0.31	0	probably_damaging	1	neutral	0.41	neutral	4.59	neutral	-1.83	neutral	-1.77	low_impact	0.98	0.83	neutral	0.27	damaging	3.96	23.60	deleterious	0.09	0.35	0.34	neutral	0.87	disease	0.56	disease	0.75	disease	5	1	deleterious	0.21	neutral	-2	neutral	0.77	deleterious	-3.54	low_impact	0.12	medium_impact	-0.32	medium_impact	0.60	0.8	2.02	8.22	0.26	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5023	5023	C	A	MI.13925	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	554	185	T	N	aCc/aAc	0.95	0.31	0	probably_damaging	1	neutral	0.31	neutral	4.6	neutral	-0.25	neutral	-2.37	neutral_impact	-0.74	0.79	neutral	0.27	damaging	3.64	23.20	deleterious	0.24	0.45	0.3	neutral	0.84	disease	0.62	disease	0.77	disease	5	1	deleterious	0.16	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	0.02	medium_impact	-1.77	low_impact	0.57	0.8	2.02	8.22	0.22	N	0.65	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5023	5023	C	G	MI.13926	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	554	185	T	S	aCc/aGc	0.95	0.31	0	probably_damaging	1	neutral	0.41	neutral	4.89	neutral	3.13	neutral	0.16	neutral_impact	-0.84	0.85	neutral	0.91	neutral	2.32	18.30	deleterious	0.23	0.45	0.36	neutral	0.28	neutral	0.45	neutral	0.44	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.12	medium_impact	-1.85	low_impact	0.58	0.8	2.02	8.22	0.36	N	0.34	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5025	5025	C	A	MI.13927	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	556	186	H	N	Cac/Aac	-3.42	0	0	probably_damaging	0.96	neutral	0.31	neutral	4.35	neutral	-2.61	deleterious	-6.68	medium_impact	2.14	0.88	neutral	0.12	damaging	3.91	23.50	deleterious	0.12	0.4	0.7	disease	0.84	disease	0.75	disease	0.6	disease	2	0.96	neutral	0.18	neutral	1	deleterious	0.82	deleterious	-2.06	low_impact	0.02	medium_impact	0.66	medium_impact	0.38	0.8	NA	NA	0.31	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5025	5025	C	G	MI.13928	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	556	186	H	D	Cac/Gac	-3.42	0	0	probably_damaging	0.96	neutral	0.2	neutral	4.25	deleterious	-4.05	deleterious	-8.59	high_impact	4.07	0.9	neutral	0.11	damaging	3.86	23.50	deleterious	0.04	0.35	0.75	disease	0.89	disease	0.82	disease	0.73	disease	5	0.97	neutral	0.12	neutral	2	deleterious	0.84	deleterious	-2.06	low_impact	-0.13	medium_impact	2.28	high_impact	0.28	0.8	NA	NA	0.53	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5025	5025	C	T	MI.13929	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	556	186	H	Y	Cac/Tac	-3.42	0	0	benign	0.14	neutral	1	neutral	4.19	deleterious	-6.1	deleterious	-5.71	high_impact	4.07	0.91	neutral	0.11	damaging	3.75	23.30	deleterious	0.05	0.35	0.71	disease	0.89	disease	0.77	disease	0.71	disease	4	0.14	neutral	0.93	deleterious	-2	neutral	0.40	neutral	-0.08	medium_impact	1.87	high_impact	2.28	high_impact	0.27	0.8	NA	NA	0.27	N	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9181	9181	A	C	MI.1393	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	655	219	S	R	Agc/Cgc	-2.88	0	0.01	probably_damaging	0.99	deleterious	0.02	neutral	4.29	neutral	-2.94	deleterious	-4.28	high_impact	3.8	0.82	neutral	0.4	neutral	3.94	23.50	deleterious	0.17	0.65	NA	NA	0.84	disease	0.79	disease	0.8	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-0.66	medium_impact	2.16	high_impact	0.77	0.9	48.23	7.68	0.43	N	1.00	polymorphism	0.57	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5026	5026	A	G	MI.13930	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	557	186	H	R	cAc/cGc	5.55	1	0	probably_damaging	0.94	neutral	0.35	neutral	4.23	deleterious	-4.17	deleterious	-7.63	high_impact	4.07	0.93	neutral	0.12	damaging	3.00	22.20	deleterious	0.04	0.35	0.68	disease	0.91	disease	0.8	disease	0.73	disease	5	0.94	neutral	0.21	neutral	2	deleterious	0.88	deleterious	-1.89	low_impact	0.06	medium_impact	2.28	high_impact	0.43	0.8	NA	NA	0.7	P	0.98	polymorphism	1	0.35	.	.	.	.	.	oral cancer	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5026	5026	A	C	MI.13931	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	557	186	H	P	cAc/cCc	5.55	1	0	probably_damaging	0.98	neutral	0.2	neutral	4.2	deleterious	-5.62	deleterious	-9.54	high_impact	3.71	0.86	neutral	0.1	damaging	3.26	22.80	deleterious	0.03	0.35	0.79	disease	0.9	disease	0.84	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-2.34	low_impact	-0.13	medium_impact	1.98	medium_impact	0.20	0.8	NA	NA	0.65	P	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5026	5026	A	T	MI.13932	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	557	186	H	L	cAc/cTc	5.55	1	0	possibly_damaging	0.85	neutral	0.66	neutral	4.2	deleterious	-5.07	deleterious	-10.48	high_impact	4.07	0.93	neutral	0.1	damaging	3.93	23.50	deleterious	0.03	0.35	0.26	neutral	0.92	disease	0.77	disease	0.69	disease	4	0.82	neutral	0.41	neutral	1	deleterious	0.75	deleterious	-1.49	low_impact	0.37	medium_impact	2.28	high_impact	0.25	0.8	NA	NA	0.61	P	0.97	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5027	5027	C	A	MI.13933	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	558	186	H	Q	caC/caA	4.63	0.99	0	probably_damaging	0.98	neutral	0.29	neutral	4.54	neutral	-0.67	deleterious	-7.63	medium_impact	2.67	0.88	neutral	0.1	damaging	3.94	23.50	deleterious	0.06	0.35	0.56	disease	0.84	disease	0.75	disease	0.71	disease	4	0.98	deleterious	0.16	neutral	1	deleterious	0.82	deleterious	-2.34	low_impact	-0.01	medium_impact	1.1	medium_impact	0.38	0.8	NA	NA	0.52	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5027	5027	C	G	MI.13934	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	558	186	H	Q	caC/caG	4.63	0.99	0	probably_damaging	0.98	neutral	0.29	neutral	4.54	neutral	-0.67	deleterious	-7.63	medium_impact	2.67	0.88	neutral	0.1	damaging	3.54	23.10	deleterious	0.06	0.35	0.56	disease	0.84	disease	0.75	disease	0.71	disease	4	0.98	deleterious	0.16	neutral	1	deleterious	0.82	deleterious	-2.34	low_impact	-0.01	medium_impact	1.1	medium_impact	0.38	0.8	NA	NA	0.52	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5028	5028	A	C	MI.13935	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	559	187	M	L	Ata/Cta	-4.81	0	0	benign	0.02	neutral	1	neutral	4.63	neutral	-0.06	deleterious	-2.69	neutral_impact	0.5	0.85	neutral	0.56	neutral	0.09	3.50	deleterious	0.25	0.45	0.32	neutral	0.39	neutral	0.51	disease	0.45	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.18	neutral	0.75	medium_impact	1.87	high_impact	-0.72	medium_impact	0.31	0.8	NA	NA	0.23	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5028	5028	A	T	MI.13936	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	559	187	M	L	Ata/Tta	-4.81	0	0	benign	0.02	neutral	1	neutral	4.63	neutral	-0.06	deleterious	-2.69	neutral_impact	0.5	0.85	neutral	0.56	neutral	0.19	4.58	deleterious	0.25	0.45	0.32	neutral	0.39	neutral	0.51	disease	0.45	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.18	neutral	0.75	medium_impact	1.87	high_impact	-0.72	medium_impact	0.31	0.8	NA	NA	0.24	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5028	5028	A	G	MI.13937	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	559	187	M	V	Ata/Gta	-4.81	0	0	benign	0	neutral	0.55	neutral	4.43	neutral	-1.33	deleterious	-3.7	low_impact	1.79	0.95	neutral	0.54	neutral	0.66	8.56	deleterious	0.21	0.45	0.43	neutral	0.88	disease	0.68	disease	0.72	disease	4	0.44	neutral	0.78	deleterious	-6	neutral	0.27	neutral	1.95	medium_impact	0.26	medium_impact	0.36	medium_impact	0.40	0.8	NA	NA	0.23	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5029	5029	T	C	MI.13938	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	560	187	M	T	aTa/aCa	-0.2	0	0	benign	0.01	neutral	0.44	neutral	4.32	deleterious	-3.09	deleterious	-5.6	low_impact	1.5	0.89	neutral	0.58	neutral	1.06	10.98	neutral	0.08	0.35	0.52	disease	0.87	disease	0.69	disease	0.71	disease	4	0.55	neutral	0.72	deleterious	-6	neutral	0.31	neutral	1.03	medium_impact	0.15	medium_impact	0.12	medium_impact	0.12	0.8	NA	NA	0.31	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5029	5029	T	A	MI.13939	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	560	187	M	K	aTa/aAa	-0.2	0	0	benign	0.17	neutral	0.31	neutral	4.29	deleterious	-4.36	deleterious	-5.65	medium_impact	3.42	0.84	neutral	0.39	neutral	2.10	16.84	deleterious	0.03	0.35	0.68	disease	0.93	disease	0.77	disease	0.75	disease	5	0.63	neutral	0.57	deleterious	-3	neutral	0.44	deleterious	-0.17	medium_impact	0.02	medium_impact	1.73	medium_impact	0.17	0.8	NA	NA	0.4	N	0.98	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9181	9181	A	G	MI.1394	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	655	219	S	G	Agc/Ggc	-2.88	0	0.01	probably_damaging	0.98	neutral	0.14	neutral	4.3	neutral	-2.6	deleterious	-3.43	medium_impact	2.38	0.97	neutral	0.63	neutral	3.68	23.30	deleterious	0.35	0.65	NA	NA	0.6	disease	0.72	disease	0.68	disease	4	0.99	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-2.36	low_impact	-0.15	medium_impact	0.94	medium_impact	0.70	0.9	48.23	7.68	0.44	N	0.92	polymorphism	0.87	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5030	5030	A	C	MI.13940	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	561	187	M	I	atA/atC	5.78	0.9	0	benign	0.03	neutral	0.56	neutral	4.5	neutral	-0.79	deleterious	-3.67	low_impact	1.62	0.85	neutral	0.55	neutral	1.53	13.48	neutral	0.2	0.45	0.31	neutral	0.91	disease	0.67	disease	0.72	disease	4	0.4	neutral	0.77	deleterious	-6	neutral	0.28	neutral	0.59	medium_impact	0.27	medium_impact	0.22	medium_impact	0.36	0.8	NA	NA	0.4	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5030	5030	A	T	MI.13941	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	561	187	M	I	atA/atT	5.78	0.9	0	benign	0.03	neutral	0.56	neutral	4.5	neutral	-0.79	deleterious	-3.67	low_impact	1.62	0.85	neutral	0.55	neutral	1.66	14.17	neutral	0.2	0.45	0.31	neutral	0.91	disease	0.67	disease	0.72	disease	4	0.4	neutral	0.77	deleterious	-6	neutral	0.28	neutral	0.59	medium_impact	0.27	medium_impact	0.22	medium_impact	0.36	0.8	NA	NA	0.4	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5031	5031	G	T	MI.13942	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	562	188	G	W	Gga/Tga	-0.43	0.19	0	probably_damaging	1	neutral	0.2	neutral	3.38	deleterious	-13.66	deleterious	-7.65	high_impact	4.05	0.79	neutral	0.08	damaging	4.38	24.10	deleterious	0.03	0.35	0.99	disease	0.92	disease	0.79	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	-0.13	medium_impact	2.27	high_impact	0.08	0.8	NA	NA	0.4	N	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5031	5031	G	C	MI.13943	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	562	188	G	R	Gga/Cga	-0.43	0.19	0	probably_damaging	1	neutral	0.34	neutral	3.39	deleterious	-10.82	deleterious	-7.65	high_impact	3.7	0.89	neutral	0.1	damaging	3.90	23.50	deleterious	0.02	0.35	0.95	disease	0.92	disease	0.82	disease	0.63	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.92	deleterious	-3.54	low_impact	0.05	medium_impact	1.97	medium_impact	0.42	0.8	NA	NA	0.52	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5032	5032	G	A	MI.13944	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	563	188	G	E	gGa/gAa	6.01	1	0	probably_damaging	1	neutral	0.27	neutral	3.4	deleterious	-10.18	deleterious	-7.65	high_impact	4.05	0.8	neutral	0.09	damaging	3.94	23.50	deleterious	0.02	0.35	0.71	disease	0.9	disease	0.82	disease	0.73	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.03	medium_impact	2.27	high_impact	0.23	0.8	NA	NA	0.62	P	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5032	5032	G	T	MI.13945	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	563	188	G	V	gGa/gTa	6.01	1	0	probably_damaging	1	neutral	0.5	neutral	3.4	deleterious	-9.64	deleterious	-8.61	high_impact	4.05	0.65	neutral	0.09	damaging	3.77	23.40	deleterious	0.02	0.35	0.96	disease	0.91	disease	0.77	disease	0.61	disease	2	1	deleterious	0.25	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	0.21	medium_impact	2.27	high_impact	0.19	0.8	NA	NA	0.62	P	0.97	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5032	5032	G	C	MI.13946	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	563	188	G	A	gGa/gCa	6.01	1	0	probably_damaging	1	neutral	0.51	neutral	3.48	deleterious	-7.02	deleterious	-5.74	medium_impact	2.29	0.75	neutral	0.1	damaging	3.11	22.50	deleterious	0.03	0.35	0.88	disease	0.77	disease	0.74	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0.22	medium_impact	0.78	medium_impact	0.27	0.8	NA	NA	0.49	N	0.74	polymorphism	1	0.10	.	.	.	.	.	.	COSM1637127	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5034	5034	T	C	MI.13947	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	565	189	W	R	Tga/Cga	-8.72	0	0	probably_damaging	1	neutral	0.3	neutral	4.51	neutral	-0.82	deleterious	-13.38	high_impact	4.12	0.91	neutral	0.13	damaging	3.62	23.20	deleterious	0.02	0.35	0.89	disease	0.93	disease	0.81	disease	0.63	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	0	medium_impact	2.32	high_impact	0.14	0.8	NA	NA	0.56	P	0.97	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5034	5034	T	G	MI.13948	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	565	189	W	G	Tga/Gga	-8.72	0	0	probably_damaging	1	neutral	0.38	neutral	4.51	neutral	-0.66	deleterious	-12.43	high_impact	4.12	0.81	neutral	0.12	damaging	3.93	23.50	deleterious	0.03	0.35	0.9	disease	0.87	disease	0.77	disease	0.63	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	0.09	medium_impact	2.32	high_impact	0.09	0.8	NA	NA	0.49	N	0.96	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5035	5035	G	C	MI.13949	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	566	189	W	S	tGa/tCa	7.4	1	0	probably_damaging	1	neutral	0.53	neutral	4.53	neutral	0.18	deleterious	-13.39	high_impact	4.12	0.89	neutral	0.15	damaging	4.01	23.60	deleterious	0.02	0.35	0.83	disease	0.92	disease	0.76	disease	0.66	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	0.24	medium_impact	2.32	high_impact	0.08	0.8	NA	NA	0.57	P	0.94	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9182	9182	G	C	MI.1395	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	656	219	S	T	aGc/aCc	5.68	1	0.01	probably_damaging	0.98	neutral	0.85	neutral	4.36	neutral	-0.72	deleterious	-2.55	neutral_impact	0.53	0.82	neutral	0.58	neutral	2.34	18.45	deleterious	0.26	0.65	NA	NA	0.21	neutral	0.55	disease	0.32	neutral	4	0.98	neutral	0.44	neutral	-2	neutral	0.72	deleterious	-2.36	low_impact	0.72	medium_impact	-0.64	medium_impact	0.80	0.9	48.23	7.68	0.43	N	0.67	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5035	5035	G	T	MI.13950	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	566	189	W	L	tGa/tTa	7.4	1	0	probably_damaging	1	neutral	0.82	neutral	4.73	neutral	2.84	deleterious	-12.43	high_impact	3.57	0.75	neutral	0.1	damaging	4.23	23.90	deleterious	0.03	0.35	0.4	neutral	0.87	disease	0.75	disease	0.69	disease	4	1	deleterious	0.41	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	0.57	medium_impact	1.86	medium_impact	0.12	0.8	NA	NA	0.52	N	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5036	5036	A	C	MI.13951	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	567	189	W	C	tgA/tgC	6.01	1	0	probably_damaging	1	neutral	0.17	neutral	4.51	neutral	-1.13	deleterious	-12.43	high_impact	4.12	0.87	neutral	0.12	damaging	3.97	23.60	deleterious	0.02	0.35	0.91	disease	0.91	disease	0.8	disease	0.62	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.17	medium_impact	2.32	high_impact	0.12	0.8	NA	NA	0.67	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5036	5036	A	T	MI.13952	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	567	189	W	C	tgA/tgT	6.01	1	0	probably_damaging	1	neutral	0.17	neutral	4.51	neutral	-1.13	deleterious	-12.43	high_impact	4.12	0.87	neutral	0.12	damaging	4.08	23.70	deleterious	0.02	0.35	0.91	disease	0.91	disease	0.8	disease	0.62	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.17	medium_impact	2.32	high_impact	0.12	0.8	NA	NA	0.68	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5037	5037	A	C	MI.13953	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	568	190	M	L	Ata/Cta	5.55	1	0	probably_damaging	0.96	neutral	0.89	neutral	4.69	neutral	0.09	deleterious	-2.8	low_impact	1.56	0.95	neutral	0.16	damaging	3.25	22.80	deleterious	0.2	0.45	0.32	neutral	0.81	disease	0.63	disease	0.54	disease	1	0.96	neutral	0.47	neutral	-2	neutral	0.78	deleterious	-2.06	low_impact	0.71	medium_impact	0.17	medium_impact	0.58	0.8	NA	NA	0.47	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5037	5037	A	T	MI.13954	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	568	190	M	L	Ata/Tta	5.55	1	0	probably_damaging	0.96	neutral	0.89	neutral	4.69	neutral	0.09	deleterious	-2.8	low_impact	1.56	0.95	neutral	0.16	damaging	3.35	22.90	deleterious	0.2	0.45	0.32	neutral	0.81	disease	0.63	disease	0.54	disease	1	0.96	neutral	0.47	neutral	-2	neutral	0.78	deleterious	-2.06	low_impact	0.71	medium_impact	0.17	medium_impact	0.58	0.8	NA	NA	0.49	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5037	5037	A	G	MI.13955	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	568	190	M	V	Ata/Gta	5.55	1	0	probably_damaging	0.98	neutral	0.51	neutral	4.48	neutral	0.15	deleterious	-3.72	medium_impact	2.33	0.82	neutral	0.15	damaging	2.70	20.80	deleterious	0.19	0.45	0.38	neutral	0.84	disease	0.67	disease	0.54	disease	1	0.98	deleterious	0.27	neutral	1	deleterious	0.79	deleterious	-2.34	low_impact	0.22	medium_impact	0.82	medium_impact	0.59	0.8	NA	NA	0.47	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5038	5038	T	C	MI.13956	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	569	190	M	T	aTa/aCa	6.71	1	0	probably_damaging	0.99	neutral	0.36	neutral	4.45	neutral	-2.98	deleterious	-5.51	low_impact	1.55	0.93	neutral	0.19	damaging	2.93	22.00	deleterious	0.04	0.35	0.46	neutral	0.9	disease	0.68	disease	0.55	disease	1	0.99	deleterious	0.19	neutral	-2	neutral	0.85	deleterious	-2.62	low_impact	0.07	medium_impact	0.16	medium_impact	0.30	0.8	NA	NA	0.52	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5038	5038	T	A	MI.13957	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	569	190	M	K	aTa/aAa	6.71	1	0	probably_damaging	0.99	neutral	0.28	neutral	4.39	deleterious	-4.74	deleterious	-5.63	high_impact	3.81	0.86	neutral	0.12	damaging	4.06	23.70	deleterious	0.02	0.35	0.4	neutral	0.9	disease	0.79	disease	0.7	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-2.62	low_impact	-0.02	medium_impact	2.06	high_impact	0.35	0.8	NA	NA	0.63	P	0.98	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5039	5039	A	C	MI.13958	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	570	190	M	I	atA/atC	4.4	1	0	probably_damaging	0.98	neutral	0.87	neutral	4.54	neutral	0.47	deleterious	-3.73	low_impact	1.64	0.93	neutral	0.52	neutral	3.32	22.90	deleterious	0.17	0.45	0.32	neutral	0.86	disease	0.56	disease	0.23	neutral	5	0.98	deleterious	0.45	neutral	-2	neutral	0.81	deleterious	-2.34	low_impact	0.67	medium_impact	0.24	medium_impact	0.63	0.8	NA	NA	0.46	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5039	5039	A	T	MI.13959	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	570	190	M	I	atA/atT	4.4	1	0	probably_damaging	0.98	neutral	0.87	neutral	4.54	neutral	0.47	deleterious	-3.73	low_impact	1.64	0.93	neutral	0.52	neutral	3.38	23.00	deleterious	0.17	0.45	0.32	neutral	0.86	disease	0.56	disease	0.23	neutral	5	0.98	deleterious	0.45	neutral	-2	neutral	0.81	deleterious	-2.34	low_impact	0.67	medium_impact	0.24	medium_impact	0.63	0.8	NA	NA	0.47	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9182	9182	G	A	MI.1396	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	656	219	S	N	aGc/aAc	5.68	1	0.01	probably_damaging	0.98	neutral	0.07	neutral	4.29	deleterious	-3.16	neutral	-2.38	medium_impact	2.4	0.95	neutral	0.6	neutral	3.73	23.30	deleterious	0.56	0.65	NA	NA	0.7	disease	0.7	disease	0.66	disease	3	0.99	deleterious	0.05	neutral	1	deleterious	0.79	deleterious	-2.36	low_impact	-0.34	medium_impact	0.96	medium_impact	0.72	0.9	48.23	7.68	0.55	P	0.88	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5040	5040	A	T	MI.13960	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	571	191	M	L	Ata/Tta	0.49	0.02	0	benign	0	neutral	1	neutral	4.65	neutral	1.97	neutral	-0.95	neutral_impact	-0.42	0.89	neutral	0.96	neutral	-0.41	0.37	neutral	0.26	0.45	0.27	neutral	0.62	disease	0.37	neutral	0.2	neutral	6	0	neutral	1	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	1.87	high_impact	-1.5	low_impact	0.58	0.8	9.22	7.95	0.33	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5040	5040	A	C	MI.13961	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	571	191	M	L	Ata/Cta	0.49	0.02	0	benign	0	neutral	1	neutral	4.65	neutral	1.97	neutral	-0.95	neutral_impact	-0.42	0.89	neutral	0.96	neutral	-0.48	0.25	neutral	0.26	0.45	0.27	neutral	0.62	disease	0.37	neutral	0.2	neutral	6	0	neutral	1	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	1.87	high_impact	-1.5	low_impact	0.58	0.8	9.22	7.95	0.32	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5040	5040	A	G	MI.13962	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	571	191	M	V	Ata/Gta	0.49	0.02	0	benign	0.01	neutral	0.6	neutral	4.57	neutral	0.17	neutral	-0.56	neutral_impact	0.31	0.92	neutral	0.98	neutral	-1.18	0.01	neutral	0.24	0.45	0.29	neutral	0.59	disease	0.36	neutral	0.21	neutral	6	0.39	neutral	0.8	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.31	medium_impact	-0.88	medium_impact	0.56	0.8	9.22	7.95	0.29	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5041	5041	T	C	MI.13963	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	572	191	M	T	aTa/aCa	-0.89	0	0.01	benign	0.01	neutral	0.51	neutral	4.47	neutral	-0.35	neutral	0.06	neutral_impact	-0.1	0.96	neutral	0.99	neutral	-1.64	0.00	neutral	0.11	0.4	0.24	neutral	0.41	neutral	0.37	neutral	0.42	neutral	2	0.48	neutral	0.75	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.22	medium_impact	-1.23	low_impact	0.33	0.8	9.22	7.95	0.34	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5041	5041	T	A	MI.13964	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	572	191	M	K	aTa/aAa	-0.89	0	0.01	benign	0.27	neutral	0.32	neutral	4.42	deleterious	-3.37	neutral	-2.13	medium_impact	2.58	0.87	neutral	0.42	neutral	2.42	18.97	deleterious	0.02	0.35	0.61	disease	0.8	disease	0.64	disease	0.74	disease	5	0.61	neutral	0.53	deleterious	-3	neutral	0.56	deleterious	-0.4	medium_impact	0.03	medium_impact	1.03	medium_impact	0.37	0.8	9.22	7.95	0.3	N	0.67	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5042	5042	A	C	MI.13965	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	573	191	M	I	atA/atC	-0.89	0	0	benign	0.09	neutral	0.72	neutral	4.64	neutral	0.02	neutral	-1.14	neutral_impact	0.14	0.84	neutral	0.98	neutral	-1.00	0.02	neutral	0.24	0.45	0.22	neutral	0.48	neutral	0.29	neutral	0.35	neutral	3	0.18	neutral	0.82	deleterious	-6	neutral	0.26	neutral	0.12	medium_impact	0.44	medium_impact	-1.03	low_impact	0.65	0.8	9.22	7.95	0.29	N	0.30	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5042	5042	A	T	MI.13966	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	573	191	M	I	atA/atT	-0.89	0	0	benign	0.09	neutral	0.72	neutral	4.64	neutral	0.02	neutral	-1.14	neutral_impact	0.14	0.84	neutral	0.98	neutral	-0.83	0.04	neutral	0.24	0.45	0.22	neutral	0.48	neutral	0.29	neutral	0.35	neutral	3	0.18	neutral	0.82	deleterious	-6	neutral	0.26	neutral	0.12	medium_impact	0.44	medium_impact	-1.03	low_impact	0.65	0.8	9.22	7.95	0.3	N	0.30	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5043	5043	G	A	MI.13967	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	574	192	A	T	Gca/Aca	-5.04	0	0	benign	0.09	neutral	0.37	neutral	4.54	neutral	-1.92	neutral	-2.38	low_impact	0.98	0.94	neutral	0.92	neutral	2.84	21.60	deleterious	0.11	0.4	0.68	disease	0.52	disease	0.3	neutral	0.27	neutral	5	0.58	neutral	0.64	deleterious	-6	neutral	0.30	neutral	0.12	medium_impact	0.08	medium_impact	-0.32	medium_impact	0.74	0.85	NA	NA	0.38	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5043	5043	G	T	MI.13968	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	574	192	A	S	Gca/Tca	-5.04	0	0	benign	0.42	neutral	0.67	neutral	4.57	neutral	-2.56	neutral	-1.98	low_impact	0.86	0.66	neutral	0.92	neutral	2.35	18.50	deleterious	0.19	0.45	0.69	disease	0.54	disease	0.28	neutral	0.27	neutral	5	0.34	neutral	0.63	deleterious	-6	neutral	0.62	deleterious	-0.67	medium_impact	0.38	medium_impact	-0.42	medium_impact	0.43	0.8	NA	NA	0.31	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5043	5043	G	C	MI.13969	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	574	192	A	P	Gca/Cca	-5.04	0	0	possibly_damaging	0.9	neutral	0.17	neutral	4.48	deleterious	-4.58	deleterious	-3.83	medium_impact	2.22	0.87	neutral	0.34	neutral	3.79	23.40	deleterious	0.03	0.35	0.87	disease	0.85	disease	0.64	disease	0.67	disease	3	0.94	neutral	0.14	neutral	0	NA	0.86	deleterious	-1.67	low_impact	-0.17	medium_impact	0.72	medium_impact	0.55	0.8	NA	NA	0.39	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9182	9182	G	T	MI.1397	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	656	219	S	I	aGc/aTc	5.68	1	0.01	probably_damaging	0.99	neutral	0.06	neutral	4.45	neutral	-1	deleterious	-5.23	medium_impact	2.25	0.84	neutral	0.6	neutral	4.20	23.90	deleterious	0.27	0.65	NA	NA	0.79	disease	0.63	disease	0.54	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	-0.38	medium_impact	0.83	medium_impact	0.77	0.9	48.23	7.68	0.48	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5044	5044	C	G	MI.13970	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	575	192	A	G	gCa/gGa	-1.12	0	0	possibly_damaging	0.7	neutral	0.31	neutral	4.66	neutral	-1.13	deleterious	-3.33	low_impact	1.92	0.9	neutral	0.62	neutral	3.93	23.50	deleterious	0.13	0.4	0.83	disease	0.58	disease	0.49	neutral	0.52	disease	0	0.76	neutral	0.31	neutral	-3	neutral	0.71	deleterious	-1.13	low_impact	0.02	medium_impact	0.47	medium_impact	0.58	0.8	NA	NA	0.43	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5044	5044	C	A	MI.13971	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	575	192	A	E	gCa/gAa	-1.12	0	0	possibly_damaging	0.8	neutral	0.21	neutral	4.49	deleterious	-4.49	deleterious	-3.79	medium_impact	3.12	0.91	neutral	0.45	neutral	4.49	24.30	deleterious	0.03	0.35	0.85	disease	0.83	disease	0.63	disease	0.67	disease	3	0.88	neutral	0.21	neutral	0	NA	0.83	deleterious	-1.35	low_impact	-0.11	medium_impact	1.48	medium_impact	0.37	0.8	NA	NA	0.47	N	0.91	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5044	5044	C	T	MI.13972	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	575	192	A	V	gCa/gTa	-1.12	0	0	benign	0.42	neutral	0.65	neutral	4.63	neutral	-0.47	neutral	-2.41	low_impact	1.16	0.77	neutral	0.92	neutral	2.99	22.20	deleterious	0.12	0.4	0.37	neutral	0.62	disease	0.32	neutral	0.21	neutral	6	0.35	neutral	0.62	deleterious	-6	neutral	0.53	deleterious	-0.67	medium_impact	0.36	medium_impact	-0.17	medium_impact	0.68	0.85	NA	NA	0.25	N	0.52	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5046	5046	G	C	MI.13973	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	577	193	V	L	Gtt/Ctt	-4.11	0	0.04	benign	0.22	neutral	0.99	neutral	4.69	neutral	0.11	neutral	-1.38	low_impact	0.92	0.89	neutral	0.5	neutral	1.84	15.21	deleterious	0.12	0.4	0.38	neutral	0.75	disease	0.57	disease	0.67	disease	3	0.2	neutral	0.89	deleterious	-6	neutral	0.42	neutral	-0.29	medium_impact	1.32	medium_impact	-0.37	medium_impact	0.51	0.8	NA	NA	0.23	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5046	5046	G	A	MI.13974	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	577	193	V	I	Gtt/Att	-4.11	0	0.04	benign	0.02	neutral	0.83	neutral	4.84	neutral	-0.09	neutral	0.37	neutral_impact	-0.83	0.88	neutral	0.94	neutral	-1.05	0.01	neutral	0.29	0.45	0.35	neutral	0.12	neutral	0.28	neutral	0.21	neutral	6	0.12	neutral	0.91	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.59	medium_impact	-1.84	low_impact	0.66	0.8	NA	NA	0.3	N	0.18	polymorphism	1	0.01	rs878927053	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5046	5046	G	T	MI.13975	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	577	193	V	F	Gtt/Ttt	-4.11	0	0.04	possibly_damaging	0.81	neutral	0.72	neutral	4.59	neutral	-1.24	deleterious	-3.21	medium_impact	2.08	0.85	neutral	0.46	neutral	3.65	23.20	deleterious	0.05	0.35	0.36	neutral	0.88	disease	0.63	disease	0.74	disease	5	0.77	neutral	0.46	neutral	0	NA	0.72	deleterious	-1.37	low_impact	0.44	medium_impact	0.61	medium_impact	0.40	0.8	NA	NA	0.21	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5047	5047	T	G	MI.13976	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	578	193	V	G	gTt/gGt	-0.43	0	0	possibly_damaging	0.66	neutral	0.38	neutral	4.52	neutral	0.85	deleterious	-6.29	low_impact	0.92	0.89	neutral	0.45	neutral	3.75	23.30	deleterious	0.05	0.35	0.5	disease	0.79	disease	0.63	disease	0.7	disease	4	0.69	neutral	0.36	neutral	-3	neutral	0.66	deleterious	-1.06	low_impact	0.09	medium_impact	-0.37	medium_impact	0.26	0.8	NA	NA	0.32	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5047	5047	T	C	MI.13977	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	578	193	V	A	gTt/gCt	-0.43	0	0	benign	0.33	neutral	0.56	neutral	4.68	neutral	0.96	deleterious	-3.51	neutral_impact	0.22	0.88	neutral	0.77	neutral	0.86	9.84	deleterious	0.09	0.35	0.57	disease	0.62	disease	0.45	neutral	0.2	neutral	6	0.35	neutral	0.62	deleterious	-6	neutral	0.49	deleterious	-0.52	medium_impact	0.27	medium_impact	-0.96	medium_impact	0.17	0.8	NA	NA	0.26	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5047	5047	T	A	MI.13978	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	578	193	V	D	gTt/gAt	-0.43	0	0	possibly_damaging	0.81	neutral	0.26	neutral	4.51	deleterious	-4.61	deleterious	-5.57	medium_impact	2.62	0.84	neutral	0.38	neutral	4.56	24.40	deleterious	0.02	0.35	0.88	disease	0.89	disease	0.72	disease	0.65	disease	3	0.86	neutral	0.23	neutral	0	NA	0.80	deleterious	-1.37	low_impact	-0.04	medium_impact	1.06	medium_impact	0.14	0.8	NA	NA	0.28	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5049	5049	C	G	MI.13979	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	580	194	L	V	Cta/Gta	-9.18	0	0.03	possibly_damaging	0.79	neutral	0.59	neutral	4.37	neutral	-1.8	neutral	-1.39	low_impact	1.8	0.91	neutral	0.95	neutral	2.31	18.22	deleterious	0.3	0.45	0.72	disease	0.58	disease	0.41	neutral	0.24	neutral	5	0.76	neutral	0.4	neutral	-3	neutral	0.72	deleterious	-1.32	low_impact	0.3	medium_impact	0.37	medium_impact	0.61	0.8	1.15	7.21	0.24	N	0.51	polymorphism	1	0.03	rs28494478	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9184	9184	C	A	MI.1398	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	658	220	L	I	Ctc/Atc	-0.1	0.34	0	probably_damaging	0.99	neutral	0.09	neutral	4.21	neutral	-0.71	neutral	-1.77	medium_impact	2.21	0.57	damaging	0.57	neutral	4.16	23.80	deleterious	0.44	0.65	NA	NA	0.41	neutral	0.65	disease	0.36	neutral	3	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	-0.28	medium_impact	0.8	medium_impact	0.73	0.9	50	8.8	0.38	N	0.87	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5049	5049	C	A	MI.13980	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	580	194	L	M	Cta/Ata	-9.18	0	0.03	possibly_damaging	0.58	neutral	0.28	neutral	4.3	deleterious	-3.49	neutral	-0.97	neutral_impact	0.48	0.94	neutral	0.92	neutral	2.23	17.71	deleterious	0.27	0.45	0.79	disease	0.39	neutral	0.33	neutral	0.65	disease	3	0.73	neutral	0.35	neutral	-3	neutral	0.65	deleterious	-0.93	medium_impact	-0.02	medium_impact	-0.74	medium_impact	0.36	0.8	1.15	7.21	0.44	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5050	5050	T	C	MI.13981	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	581	194	L	P	cTa/cCa	-7.11	0	0	probably_damaging	0.99	neutral	0.2	neutral	4.22	deleterious	-5.92	deleterious	-5.44	medium_impact	3.27	0.74	neutral	0.34	neutral	3.84	23.40	deleterious	0.02	0.35	0.53	disease	0.88	disease	0.74	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	1	deleterious	0.82	deleterious	-2.62	low_impact	-0.13	medium_impact	1.61	medium_impact	0.24	0.8	1.15	7.21	0.33	N	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5050	5050	T	A	MI.13982	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	581	194	L	Q	cTa/cAa	-7.11	0	0	probably_damaging	0.98	neutral	0.37	neutral	4.23	deleterious	-5.4	deleterious	-4.67	medium_impact	2.93	0.85	neutral	0.49	neutral	3.99	23.60	deleterious	0.03	0.35	0.93	disease	0.8	disease	0.62	disease	0.68	disease	4	0.98	deleterious	0.2	neutral	1	deleterious	0.84	deleterious	-2.34	low_impact	0.08	medium_impact	1.32	medium_impact	0.32	0.8	1.15	7.21	0.3	N	0.98	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5050	5050	T	G	MI.13983	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	581	194	L	R	cTa/cGa	-7.11	0	0	probably_damaging	0.98	neutral	0.32	neutral	4.23	deleterious	-5.36	deleterious	-4.81	medium_impact	3.27	0.8	neutral	0.38	neutral	4.07	23.70	deleterious	0.01	0.35	0.93	disease	0.92	disease	0.75	disease	0.64	disease	3	0.98	neutral	0.17	neutral	1	deleterious	0.91	deleterious	-2.34	low_impact	0.03	medium_impact	1.61	medium_impact	0.25	0.8	1.15	7.21	0.34	N	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5052	5052	C	G	MI.13984	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	583	195	P	A	Ccg/Gcg	-6.88	0	0	benign	0	neutral	0.48	neutral	4.77	neutral	2.12	neutral	0.93	neutral_impact	0.12	0.84	neutral	0.94	neutral	1.01	10.71	neutral	0.23	0.45	0.41	neutral	0.31	neutral	0.42	neutral	0.43	neutral	1	0.52	neutral	0.74	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.19	medium_impact	-1.04	low_impact	0.66	0.8	15.27	10.13	0.37	N	0.64	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5052	5052	C	A	MI.13985	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	583	195	P	T	Ccg/Acg	-6.88	0	0	benign	0.01	neutral	0.42	neutral	4.69	neutral	0.23	neutral	2.03	neutral_impact	-0.76	0.98	neutral	0.98	neutral	1.40	12.80	neutral	0.19	0.45	0.59	disease	0.29	neutral	0.25	neutral	0.54	disease	1	0.57	neutral	0.71	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.13	medium_impact	-1.78	low_impact	0.57	0.8	15.27	10.13	0.36	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5052	5052	C	T	MI.13986	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	583	195	P	S	Ccg/Tcg	-6.88	0	0	benign	0.12	neutral	0.45	neutral	4.87	neutral	0.86	neutral	0.75	neutral_impact	-0.22	0.75	neutral	0.93	neutral	2.12	16.97	deleterious	0.24	0.45	0.53	disease	0.29	neutral	0.3	neutral	0.39	neutral	2	0.48	neutral	0.67	deleterious	-6	neutral	0.26	neutral	-0.01	medium_impact	0.16	medium_impact	-1.33	low_impact	0.26	0.8	15.27	10.13	0.37	N	0.75	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5053	5053	C	A	MI.13987	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	584	195	P	Q	cCg/cAg	-5.27	0	0	benign	0.43	neutral	0.31	neutral	4.66	neutral	-0.94	neutral	-0.39	neutral_impact	-0.17	0.82	neutral	0.76	neutral	2.69	20.80	deleterious	0.14	0.4	0.67	disease	0.34	neutral	0.36	neutral	0.61	disease	2	0.64	neutral	0.44	neutral	-6	neutral	0.52	deleterious	-0.69	medium_impact	0.02	medium_impact	-1.29	low_impact	0.40	0.8	15.27	10.13	0.37	N	0.87	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5053	5053	C	T	MI.13988	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	584	195	P	L	cCg/cTg	-5.27	0	0	benign	0.05	neutral	0.7	neutral	4.66	neutral	0.59	neutral	0.48	neutral_impact	-0.64	0.87	neutral	0.94	neutral	1.97	16.05	deleterious	0.11	0.4	0.7	disease	0.52	disease	0.44	neutral	0.29	neutral	4	0.23	neutral	0.83	deleterious	-6	neutral	0.22	neutral	0.37	medium_impact	0.41	medium_impact	-1.68	low_impact	0.62	0.8	15.27	10.13	0.25	N	0.84	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5053	5053	C	G	MI.13989	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	584	195	P	R	cCg/cGg	-5.27	0	0	benign	0.3	neutral	0.32	neutral	4.66	neutral	-1.52	neutral	-0.82	medium_impact	1.98	0.91	neutral	0.41	neutral	1.92	15.73	deleterious	0.11	0.4	0.78	disease	0.72	disease	0.63	disease	0.7	disease	4	0.61	neutral	0.51	deleterious	-3	neutral	0.54	deleterious	-0.46	medium_impact	0.03	medium_impact	0.52	medium_impact	0.46	0.8	15.27	10.13	0.31	N	0.92	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9184	9184	C	G	MI.1399	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	658	220	L	V	Ctc/Gtc	-0.1	0.34	0	probably_damaging	0.99	deleterious	0	neutral	4.32	neutral	0.6	deleterious	-2.66	medium_impact	2.72	0.32	damaging	0.44	neutral	3.54	23.10	deleterious	0.46	0.65	NA	NA	0.44	neutral	0.65	disease	0.41	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-2.65	low_impact	-1.4	low_impact	1.23	medium_impact	0.76	0.9	50	8.8	0.68	P	0.87	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5055	5055	T	C	MI.13990	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	586	196	Y	H	Tac/Cac	-8.95	0	0	benign	0.19	neutral	0.37	neutral	4.61	neutral	-2.64	deleterious	-4.47	medium_impact	2.17	0.88	neutral	0.28	neutral	3.60	23.20	deleterious	0.17	0.45	0.86	disease	0.85	disease	0.7	disease	0.57	disease	1	0.56	neutral	0.59	deleterious	-3	neutral	0.46	deleterious	-0.22	medium_impact	0.08	medium_impact	0.68	medium_impact	0.31	0.8	NA	NA	0.31	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5055	5055	T	A	MI.13991	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	586	196	Y	N	Tac/Aac	-8.95	0	0	probably_damaging	0.95	neutral	0.27	neutral	4.65	neutral	-2.48	deleterious	-8.03	low_impact	1.88	0.87	neutral	0.14	damaging	4.07	23.70	deleterious	0.12	0.4	0.84	disease	0.87	disease	0.67	disease	0.63	disease	3	0.96	neutral	0.16	neutral	-2	neutral	0.81	deleterious	-1.97	low_impact	-0.03	medium_impact	0.44	medium_impact	0.23	0.8	NA	NA	0.35	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5055	5055	T	G	MI.13992	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	586	196	Y	D	Tac/Gac	-8.95	0	0	probably_damaging	0.97	neutral	0.14	neutral	4.61	deleterious	-3.13	deleterious	-8.85	medium_impact	3.07	0.9	neutral	0.11	damaging	4.03	23.60	deleterious	0.06	0.35	0.9	disease	0.91	disease	0.77	disease	0.67	disease	3	0.99	deleterious	0.09	neutral	1	deleterious	0.81	deleterious	-2.18	low_impact	-0.23	medium_impact	1.44	medium_impact	0.20	0.8	NA	NA	0.48	N	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5056	5056	A	G	MI.13993	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	587	196	Y	C	tAc/tGc	2.79	0.6	0	probably_damaging	0.99	neutral	0.12	neutral	4.61	neutral	-2.31	deleterious	-7.94	medium_impact	2.03	0.76	neutral	0.1	damaging	3.59	23.20	deleterious	0.06	0.35	0.75	disease	0.92	disease	0.71	disease	0.71	disease	4	0.99	deleterious	0.07	neutral	1	deleterious	0.80	deleterious	-2.62	low_impact	-0.27	medium_impact	0.56	medium_impact	0.09	0.8	NA	NA	0.35	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5056	5056	A	T	MI.13994	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	587	196	Y	F	tAc/tTc	2.79	0.6	0	possibly_damaging	0.9	neutral	0.68	neutral	4.66	neutral	0.14	deleterious	-2.75	neutral_impact	0.66	0.89	neutral	0.91	neutral	2.20	17.51	deleterious	0.31	0.45	0.46	neutral	0.62	disease	0.38	neutral	0.23	neutral	5	0.88	neutral	0.39	neutral	-3	neutral	0.73	deleterious	-1.67	low_impact	0.39	medium_impact	-0.59	medium_impact	0.50	0.8	NA	NA	0.31	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5056	5056	A	C	MI.13995	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	587	196	Y	S	tAc/tCc	2.79	0.6	0	probably_damaging	0.95	neutral	0.47	neutral	4.64	neutral	-0.89	deleterious	-7.91	low_impact	1.49	0.85	neutral	0.13	damaging	3.80	23.40	deleterious	0.1	0.4	0.64	disease	0.88	disease	0.66	disease	0.7	disease	4	0.94	neutral	0.26	neutral	-2	neutral	0.78	deleterious	-1.97	low_impact	0.18	medium_impact	0.11	medium_impact	0.21	0.8	NA	NA	0.33	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5058	5058	A	C	MI.13996	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	589	197	N	H	Aac/Cac	-3.19	0	0	probably_damaging	0.99	neutral	0.52	neutral	4.48	neutral	-2.75	deleterious	-4.14	medium_impact	2.86	0.88	neutral	0.13	damaging	3.05	22.40	deleterious	0.32	0.5	0.95	disease	0.8	disease	0.7	disease	0.7	disease	4	0.99	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-2.62	low_impact	0.23	medium_impact	1.26	medium_impact	0.17	0.8	NA	NA	0.27	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5058	5058	A	T	MI.13997	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	589	197	N	Y	Aac/Tac	-3.19	0	0	probably_damaging	0.99	neutral	1	neutral	4.47	deleterious	-3.37	deleterious	-6.68	medium_impact	2.45	0.88	neutral	0.24	damaging	3.57	23.10	deleterious	0.11	0.4	0.96	disease	0.85	disease	0.54	disease	0.64	disease	3	0.99	deleterious	0.51	deleterious	1	deleterious	0.83	deleterious	-2.62	low_impact	1.87	high_impact	0.92	medium_impact	0.21	0.8	NA	NA	0.23	N	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5058	5058	A	G	MI.13998	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	589	197	N	D	Aac/Gac	-3.19	0	0	benign	0.14	neutral	0.2	neutral	4.57	neutral	-1.12	deleterious	-3.82	medium_impact	2.05	0.93	neutral	0.27	damaging	3.73	23.30	deleterious	0.48	0.55	0.93	disease	0.72	disease	0.6	disease	0.66	disease	3	0.77	neutral	0.53	deleterious	-3	neutral	0.35	neutral	-0.08	medium_impact	-0.13	medium_impact	0.58	medium_impact	0.40	0.8	NA	NA	0.39	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5059	5059	A	G	MI.13999	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	590	197	N	S	aAc/aGc	0.26	0	0	benign	0.34	neutral	0.44	neutral	4.58	neutral	-0.15	deleterious	-3.76	low_impact	0.83	0.87	neutral	0.79	neutral	2.47	19.28	deleterious	0.44	0.55	0.47	neutral	0.42	neutral	0.41	neutral	0.43	neutral	1	0.48	neutral	0.55	deleterious	-6	neutral	0.42	neutral	-0.53	medium_impact	0.15	medium_impact	-0.45	medium_impact	0.28	0.8	NA	NA	0.33	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8532	8532	C	A	MI.14	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	6	2	N	K	aaC/aaA	1.75	0.87	0	probably_damaging	0.97	neutral	0.07	neutral	4.69	neutral	0.02	deleterious	-3.41	medium_impact	2.6	0.87	neutral	0.44	neutral	4.56	24.40	deleterious	0.78	0.8	0.51	disease	0.42	neutral	0.25	neutral	0.38	neutral	3	0.99	deleterious	0.05	neutral	1	deleterious	0.68	deleterious	-2.19	low_impact	-0.34	medium_impact	1.13	medium_impact	0.26	0.9	41.59	7.23	0.4	N	1.00	disease_causing	0.89	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8593	8593	A	G	MI.140	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	67	23	I	V	Atc/Gtc	-8.2	0	0	benign	0.01	neutral	1	neutral	4.44	neutral	0.42	neutral	-0.13	low_impact	0.88	0.94	neutral	0.84	neutral	-0.45	0.28	neutral	0.6	0.7	0.29	neutral	0.32	neutral	0.5	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.14	medium_impact	1.98	high_impact	-0.34	medium_impact	0.33	0.9	19.03	10.37	0.27	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9184	9184	C	T	MI.1400	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	658	220	L	F	Ctc/Ttc	-0.1	0.34	0	probably_damaging	1	neutral	0.08	neutral	4.16	neutral	-2.56	deleterious	-3.54	medium_impact	2.84	0.37	damaging	0.45	neutral	4.12	23.80	deleterious	0.46	0.65	NA	NA	0.55	disease	0.46	neutral	0.46	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.31	medium_impact	1.34	medium_impact	0.75	0.9	50	8.8	0.62	P	0.97	disease_causing	1	0.09	rs879233310	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	5059	5059	A	T	MI.14000	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	590	197	N	I	aAc/aTc	0.26	0	0	probably_damaging	0.97	neutral	0.42	neutral	4.49	deleterious	-3.29	deleterious	-7.5	medium_impact	3	0.87	neutral	0.12	damaging	4.47	24.20	deleterious	0.13	0.4	0.92	disease	0.91	disease	0.58	disease	0.62	disease	2	0.97	neutral	0.23	neutral	1	deleterious	0.83	deleterious	-2.18	low_impact	0.13	medium_impact	1.38	medium_impact	0.15	0.8	NA	NA	0.29	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5059	5059	A	C	MI.14001	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	590	197	N	T	aAc/aCc	0.26	0	0	possibly_damaging	0.77	neutral	0.38	neutral	4.63	neutral	-1.01	deleterious	-4.8	medium_impact	2.23	0.94	neutral	0.17	damaging	3.89	23.50	deleterious	0.28	0.45	0.63	disease	0.81	disease	0.59	disease	0.55	disease	1	0.78	neutral	0.31	neutral	0	NA	0.72	deleterious	-1.28	low_impact	0.09	medium_impact	0.73	medium_impact	0.28	0.8	NA	NA	0.35	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5060	5060	C	G	MI.14002	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	591	197	N	K	aaC/aaG	-0.2	0	0	possibly_damaging	0.89	neutral	0.28	neutral	4.56	neutral	-1.06	deleterious	-4.85	medium_impact	2.65	0.86	neutral	0.12	damaging	4.06	23.70	deleterious	0.27	0.45	0.91	disease	0.87	disease	0.71	disease	0.64	disease	3	0.91	neutral	0.2	neutral	0	NA	0.81	deleterious	-1.63	low_impact	-0.02	medium_impact	1.09	medium_impact	0.29	0.8	NA	NA	0.29	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5060	5060	C	A	MI.14003	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	591	197	N	K	aaC/aaA	-0.2	0	0	possibly_damaging	0.89	neutral	0.28	neutral	4.56	neutral	-1.06	deleterious	-4.85	medium_impact	2.65	0.86	neutral	0.12	damaging	4.51	24.30	deleterious	0.27	0.45	0.91	disease	0.87	disease	0.71	disease	0.64	disease	3	0.91	neutral	0.2	neutral	0	NA	0.81	deleterious	-1.63	low_impact	-0.02	medium_impact	1.09	medium_impact	0.29	0.8	NA	NA	0.3	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5061	5061	C	G	MI.14004	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	592	198	P	A	Cct/Gct	-2.27	0	0	probably_damaging	1	neutral	0.51	neutral	4.76	neutral	0.14	deleterious	-5.96	medium_impact	2.7	0.93	neutral	0.57	neutral	3.13	22.60	deleterious	0.23	0.45	0.55	disease	0.7	disease	0.73	disease	0.67	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.22	medium_impact	1.13	medium_impact	0.70	0.85	NA	NA	0.34	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5061	5061	C	A	MI.14005	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	592	198	P	T	Cct/Act	-2.27	0	0	probably_damaging	1	neutral	0.39	neutral	4.67	neutral	0.78	deleterious	-5.7	medium_impact	2.06	0.9	neutral	0.71	neutral	3.88	23.50	deleterious	0.23	0.45	0.53	disease	0.77	disease	0.46	neutral	0.17	neutral	7	1	deleterious	0.2	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.1	medium_impact	0.59	medium_impact	0.62	0.8	NA	NA	0.36	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5061	5061	C	T	MI.14006	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	592	198	P	S	Cct/Tct	-2.27	0	0	probably_damaging	1	neutral	0.41	neutral	4.77	neutral	0.3	deleterious	-5.87	medium_impact	2.01	0.95	neutral	0.58	neutral	3.87	23.50	deleterious	0.33	0.5	0.64	disease	0.81	disease	0.61	disease	0.54	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.12	medium_impact	0.55	medium_impact	0.16	0.8	NA	NA	0.35	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5062	5062	C	T	MI.14007	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	593	198	P	L	cCt/cTt	1.18	0.06	0	probably_damaging	1	neutral	0.66	neutral	4.72	neutral	-1.13	deleterious	-7.88	medium_impact	2.1	0.91	neutral	0.49	neutral	4.33	24.00	deleterious	0.17	0.45	0.39	neutral	0.88	disease	0.68	disease	0.7	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.37	medium_impact	0.62	medium_impact	0.68	0.85	NA	NA	0.33	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5062	5062	C	G	MI.14008	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	593	198	P	R	cCt/cGt	1.18	0.06	0	probably_damaging	1	neutral	0.34	neutral	4.66	neutral	-1.43	deleterious	-6.98	medium_impact	3.4	0.88	neutral	0.43	neutral	3.64	23.20	deleterious	0.08	0.35	0.84	disease	0.91	disease	0.81	disease	0.67	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	0.05	medium_impact	1.72	medium_impact	0.35	0.8	NA	NA	0.49	N	0.56	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5062	5062	C	A	MI.14009	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	593	198	P	H	cCt/cAt	1.18	0.06	0	probably_damaging	1	neutral	0.54	neutral	4.63	neutral	-2.6	deleterious	-7.12	medium_impact	2.77	0.93	neutral	0.44	neutral	3.98	23.60	deleterious	0.1	0.4	0.88	disease	0.86	disease	0.74	disease	0.63	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.25	medium_impact	1.19	medium_impact	0.28	0.8	NA	NA	0.35	N	0.71	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9185	9185	T	C	MI.1401	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	659	220	L	P	cTc/cCc	0.82	0.48	0	probably_damaging	1	deleterious	0	neutral	4.08	deleterious	-4.18	deleterious	-6.22	high_impact	4.3	0.2	damaging	0.42	neutral	3.99	23.60	deleterious	0.2	0.65	NA	NA	0.67	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.59	high_impact	0.48	0.9	50	8.8	0.94	P	1.00	disease_causing_automatic	1	0.32	rs199476138	Pathogenic	Charcot-Marie-Tooth_disease|Leigh_syndrome|Mitochondrial_diseases	24686	MedGen:C0007959,Orphanet:ORPHA166,SNOMED_CT:50548001|MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C0751651,Orphanet:ORPHA68380	.	.	.	.	T9185C	Leigh Disease / Ataxia syndromes / NARP-like disease	+	+	Cfrm	12	P	P	P	damaging
chrM	5064	5064	A	G	MI.14010	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	595	199	N	D	Aac/Gac	-11.25	0	0	benign	0.01	neutral	0.19	neutral	4.62	neutral	-0.93	neutral	-1.36	medium_impact	2.04	0.89	neutral	0.67	neutral	0.85	9.79	deleterious	0.59	0.65	0.83	disease	0.58	disease	0.33	neutral	0.37	neutral	3	0.81	neutral	0.59	deleterious	-3	neutral	0.23	neutral	1.03	medium_impact	-0.14	medium_impact	0.57	medium_impact	0.32	0.8	1.15	8.22	0.39	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5064	5064	A	C	MI.14011	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	595	199	N	H	Aac/Cac	-11.25	0	0	possibly_damaging	0.86	neutral	0.5	neutral	4.61	neutral	-1.31	neutral	-2.44	low_impact	0.92	0.86	neutral	0.68	neutral	2.91	21.90	deleterious	0.39	0.5	0.77	disease	0.54	disease	0.37	neutral	0.27	neutral	5	0.84	neutral	0.32	neutral	-3	neutral	0.71	deleterious	-1.52	low_impact	0.21	medium_impact	-0.37	medium_impact	0.22	0.8	1.15	8.22	0.25	N	0.33	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5064	5064	A	T	MI.14012	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	595	199	N	Y	Aac/Tac	-11.25	0	0	possibly_damaging	0.8	neutral	1	neutral	4.77	neutral	1.88	deleterious	-3.27	low_impact	1.21	0.92	neutral	0.58	neutral	3.65	23.20	deleterious	0.15	0.4	0.64	disease	0.7	disease	0.54	disease	0.6	disease	2	0.8	neutral	0.6	deleterious	-3	neutral	0.70	deleterious	-1.35	low_impact	1.87	high_impact	-0.13	medium_impact	0.28	0.8	1.15	8.22	0.26	N	0.65	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5065	5065	A	G	MI.14013	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	596	199	N	S	aAc/aGc	-1.81	0	0	benign	0.2	neutral	0.48	neutral	4.71	neutral	1.25	neutral	-0.19	neutral_impact	0.32	0.87	neutral	0.99	neutral	-0.45	0.29	neutral	0.52	0.6	0.46	neutral	0.38	neutral	0.27	neutral	0.46	neutral	1	0.42	neutral	0.64	deleterious	-6	neutral	0.30	neutral	-0.25	medium_impact	0.19	medium_impact	-0.88	medium_impact	0.12	0.8	1.15	8.22	0.41	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5065	5065	A	C	MI.14014	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	596	199	N	T	aAc/aCc	-1.81	0	0	benign	0.02	neutral	0.44	neutral	4.69	neutral	0.89	neutral	1.24	neutral_impact	-0.18	0.9	neutral	0.97	neutral	-0.97	0.02	neutral	0.33	0.5	0.51	disease	0.36	neutral	0.21	neutral	0.33	neutral	3	0.54	neutral	0.71	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	0.15	medium_impact	-1.3	low_impact	0.37	0.8	1.15	8.22	0.36	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5065	5065	A	T	MI.14015	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	596	199	N	I	aAc/aTc	-1.81	0	0	benign	0.41	neutral	0.44	neutral	4.79	neutral	2.05	deleterious	-2.88	low_impact	1.93	0.9	neutral	0.65	neutral	3.69	23.30	deleterious	0.16	0.45	0.45	neutral	0.79	disease	0.5	neutral	0.56	disease	1	0.5	neutral	0.52	deleterious	-6	neutral	0.56	deleterious	-0.65	medium_impact	0.15	medium_impact	0.48	medium_impact	0.18	0.8	1.15	8.22	0.34	N	0.63	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5066	5066	C	G	MI.14016	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	597	199	N	K	aaC/aaG	0.03	0	0	benign	0.36	neutral	0.3	neutral	4.67	neutral	0.64	neutral	-1.97	neutral_impact	0.45	0.8	neutral	0.64	neutral	1.19	11.71	neutral	0.48	0.55	0.7	disease	0.32	neutral	0.31	neutral	0.64	disease	3	0.64	neutral	0.47	deleterious	-6	neutral	0.49	deleterious	-0.57	medium_impact	0	medium_impact	-0.77	medium_impact	0.49	0.8	1.15	8.22	0.34	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5066	5066	C	A	MI.14017	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	597	199	N	K	aaC/aaA	0.03	0	0	benign	0.36	neutral	0.3	neutral	4.67	neutral	0.64	neutral	-1.97	neutral_impact	0.45	0.8	neutral	0.64	neutral	1.72	14.52	neutral	0.48	0.55	0.7	disease	0.32	neutral	0.31	neutral	0.64	disease	3	0.64	neutral	0.47	deleterious	-6	neutral	0.49	deleterious	-0.57	medium_impact	0	medium_impact	-0.77	medium_impact	0.49	0.8	1.15	8.22	0.34	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5067	5067	A	C	MI.14018	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	598	200	M	L	Ata/Cta	-6.65	0	0	benign	0.01	neutral	1	neutral	4.83	neutral	2.05	neutral	-0.22	neutral_impact	-0.74	0.9	neutral	0.96	neutral	-1.49	0.00	neutral	0.39	0.5	0.38	neutral	0.19	neutral	0.29	neutral	0.34	neutral	3	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	1.87	high_impact	-1.77	low_impact	0.25	0.8	1.73	8.56	0.35	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5067	5067	A	T	MI.14019	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	598	200	M	L	Ata/Tta	-6.65	0	0	benign	0.01	neutral	1	neutral	4.83	neutral	2.05	neutral	-0.22	neutral_impact	-0.74	0.9	neutral	0.96	neutral	-1.41	0.00	neutral	0.39	0.5	0.38	neutral	0.19	neutral	0.29	neutral	0.34	neutral	3	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	1.87	high_impact	-1.77	low_impact	0.25	0.8	1.73	8.56	0.34	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9185	9185	T	G	MI.1402	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	659	220	L	R	cTc/cGc	0.82	0.48	0	probably_damaging	1	deleterious	0	neutral	4.09	deleterious	-3.54	deleterious	-5.32	high_impact	4.3	0.15	damaging	0.34	neutral	4.32	24.00	deleterious	0.19	0.65	NA	NA	0.78	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.59	high_impact	0.54	0.9	50	8.8	0.95	P	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5067	5067	A	G	MI.14020	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	598	200	M	V	Ata/Gta	-6.65	0	0	benign	0	neutral	0.31	neutral	4.72	neutral	1.19	neutral	-1.38	low_impact	1.11	0.93	neutral	0.77	neutral	0.70	8.81	deleterious	0.31	0.45	0.47	neutral	0.63	disease	0.67	disease	0.7	disease	4	0.69	neutral	0.66	deleterious	-6	neutral	0.21	neutral	1.95	medium_impact	0.02	medium_impact	-0.21	medium_impact	0.28	0.8	1.73	8.56	0.32	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5068	5068	T	C	MI.14021	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	599	200	M	T	aTa/aCa	-0.66	0	0	benign	0	neutral	0.46	neutral	4.66	neutral	0.3	deleterious	-3.42	low_impact	0.88	0.96	neutral	0.85	neutral	0.02	2.74	deleterious	0.18	0.45	0.4	neutral	0.63	disease	0.58	disease	0.61	disease	2	0.53	neutral	0.73	deleterious	-6	neutral	0.24	neutral	1.95	medium_impact	0.17	medium_impact	-0.4	medium_impact	0.11	0.8	1.73	8.56	0.3	N	0.02	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5068	5068	T	A	MI.14022	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	599	200	M	K	aTa/aAa	-0.66	0	0	benign	0.12	neutral	0.09	neutral	4.61	neutral	-1.04	deleterious	-4.32	medium_impact	2.7	0.84	neutral	0.41	neutral	2.23	17.68	deleterious	0.04	0.35	0.79	disease	0.8	disease	0.74	disease	0.71	disease	4	0.9	neutral	0.49	deleterious	-3	neutral	0.42	neutral	-0.01	medium_impact	-0.35	medium_impact	1.13	medium_impact	0.13	0.8	1.73	8.56	0.34	N	0.81	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5069	5069	A	C	MI.14023	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	600	200	M	I	atA/atC	3.02	0.15	0	benign	0	neutral	0.34	neutral	4.72	neutral	1.15	neutral	-0.92	neutral_impact	0.38	0.9	neutral	0.98	neutral	-0.02	2.40	deleterious	0.3	0.45	0.41	neutral	0.43	neutral	0.35	neutral	0.42	neutral	2	0.66	neutral	0.67	deleterious	-6	neutral	0.20	neutral	1.95	medium_impact	0.05	medium_impact	-0.83	medium_impact	0.23	0.8	1.73	8.56	0.41	N	0.06	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5069	5069	A	T	MI.14024	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	600	200	M	I	atA/atT	3.02	0.15	0	benign	0	neutral	0.34	neutral	4.72	neutral	1.15	neutral	-0.92	neutral_impact	0.38	0.9	neutral	0.98	neutral	0.01	2.70	deleterious	0.3	0.45	0.41	neutral	0.43	neutral	0.35	neutral	0.42	neutral	2	0.66	neutral	0.67	deleterious	-6	neutral	0.20	neutral	1.95	medium_impact	0.05	medium_impact	-0.83	medium_impact	0.23	0.8	1.73	8.56	0.41	N	0.06	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5070	5070	A	G	MI.14025	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	601	201	T	A	Acc/Gcc	-11.94	0	0	benign	0.11	neutral	0.51	neutral	5.03	neutral	2.49	deleterious	-2.52	neutral_impact	0.75	0.88	neutral	0.94	neutral	0.45	7.05	deleterious	0.28	0.45	0.55	disease	0.25	neutral	0.44	neutral	0.54	disease	1	0.41	neutral	0.7	deleterious	-6	neutral	0.22	neutral	0.03	medium_impact	0.22	medium_impact	-0.51	medium_impact	0.35	0.8	0.86	7.69	0.42	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5070	5070	A	C	MI.14026	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	601	201	T	P	Acc/Ccc	-11.94	0	0	probably_damaging	0.95	neutral	0.2	neutral	4.56	neutral	-2.46	deleterious	-3.76	medium_impact	2.33	0.79	neutral	0.34	neutral	3.26	22.80	deleterious	0.06	0.35	0.67	disease	0.8	disease	0.72	disease	0.68	disease	4	0.97	neutral	0.13	neutral	1	deleterious	0.80	deleterious	-1.97	low_impact	-0.13	medium_impact	0.82	medium_impact	0.34	0.8	0.86	7.69	0.26	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5070	5070	A	T	MI.14027	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	601	201	T	S	Acc/Tcc	-11.94	0	0	possibly_damaging	0.72	neutral	0.42	neutral	4.71	neutral	0.81	neutral	-1.95	neutral_impact	0.74	0.87	neutral	0.91	neutral	0.42	6.82	deleterious	0.33	0.5	0.62	disease	0.51	disease	0.38	neutral	0.25	neutral	5	0.73	neutral	0.35	neutral	-3	neutral	0.68	deleterious	-1.17	low_impact	0.13	medium_impact	-0.52	medium_impact	0.65	0.8	0.86	7.69	0.34	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5071	5071	C	T	MI.14028	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	602	201	T	I	aCc/aTc	0.26	0	0	probably_damaging	0.91	neutral	0.41	neutral	4.6	neutral	-0.92	deleterious	-2.86	medium_impact	2.58	0.88	neutral	0.57	neutral	3.50	23.10	deleterious	0.17	0.45	0.76	disease	0.74	disease	0.59	disease	0.64	disease	3	0.91	neutral	0.25	neutral	1	deleterious	0.75	deleterious	-1.72	low_impact	0.12	medium_impact	1.03	medium_impact	0.69	0.85	0.86	7.69	0.33	N	0.80	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5071	5071	C	A	MI.14029	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	602	201	T	N	aCc/aAc	0.26	0	0	probably_damaging	0.95	neutral	0.31	neutral	4.58	neutral	-1.58	deleterious	-3.12	medium_impact	3.13	0.85	neutral	0.49	neutral	3.52	23.10	deleterious	0.25	0.45	0.68	disease	0.68	disease	0.62	disease	0.64	disease	3	0.96	neutral	0.18	neutral	1	deleterious	0.75	deleterious	-1.97	low_impact	0.02	medium_impact	1.49	medium_impact	0.62	0.8	0.86	7.69	0.33	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9185	9185	T	A	MI.1403	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	659	220	L	H	cTc/cAc	0.82	0.48	0	probably_damaging	1	deleterious	0	neutral	4.08	deleterious	-4.12	deleterious	-6.2	high_impact	4.3	0.38	damaging	0.38	neutral	4.22	23.90	deleterious	0.22	0.65	NA	NA	0.7	disease	0.73	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.59	high_impact	0.58	0.9	50	8.8	0.66	P	0.97	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5071	5071	C	G	MI.14030	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	602	201	T	S	aCc/aGc	0.26	0	0	possibly_damaging	0.72	neutral	0.42	neutral	4.71	neutral	0.81	neutral	-1.95	neutral_impact	0.74	0.87	neutral	0.91	neutral	0.60	8.13	deleterious	0.33	0.5	0.62	disease	0.51	disease	0.38	neutral	0.25	neutral	5	0.73	neutral	0.35	neutral	-3	neutral	0.68	deleterious	-1.17	low_impact	0.13	medium_impact	-0.52	medium_impact	0.65	0.8	0.86	7.69	0.35	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5073	5073	A	C	MI.14031	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	604	202	I	L	Att/Ctt	-4.58	0	0	benign	0.27	neutral	1	neutral	4.64	neutral	0.06	neutral	0.2	neutral_impact	-0.32	0.87	neutral	0.97	neutral	1.06	11.01	neutral	0.23	0.45	0.39	neutral	0.11	neutral	0.28	neutral	0.22	neutral	6	0.27	neutral	0.87	deleterious	-6	neutral	0.28	neutral	-0.4	medium_impact	1.87	high_impact	-1.41	low_impact	0.57	0.8	0.29	6.64	0.32	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5073	5073	A	G	MI.14032	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	604	202	I	V	Att/Gtt	-4.58	0	0	benign	0.03	neutral	0.11	neutral	4.53	neutral	-0.6	neutral	-0.46	low_impact	0.82	0.96	neutral	0.94	neutral	1.91	15.63	deleterious	0.38	0.5	0.5	neutral	0.25	neutral	0.4	neutral	0.3	neutral	4	0.89	neutral	0.54	deleterious	-6	neutral	0.15	neutral	0.59	medium_impact	-0.3	medium_impact	-0.45	medium_impact	0.47	0.8	0.29	6.64	0.48	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5073	5073	A	T	MI.14033	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	604	202	I	F	Att/Ttt	-4.58	0	0	possibly_damaging	0.76	neutral	0.38	neutral	4.55	neutral	-1.91	neutral	-2.25	neutral_impact	0.58	0.91	neutral	0.82	neutral	4.02	23.60	deleterious	0.18	0.45	0.75	disease	0.57	disease	0.53	disease	0.27	neutral	5	0.77	neutral	0.31	neutral	-3	neutral	0.71	deleterious	-1.26	low_impact	0.09	medium_impact	-0.66	medium_impact	0.54	0.8	0.29	6.64	0.39	N	0.34	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5074	5074	T	A	MI.14034	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	605	202	I	N	aTt/aAt	-11.02	0	0	possibly_damaging	0.76	neutral	0.15	neutral	4.42	deleterious	-4.09	deleterious	-4.42	medium_impact	2.8	0.88	neutral	0.42	neutral	4.40	24.10	deleterious	0.07	0.35	0.89	disease	0.68	disease	0.64	disease	0.68	disease	4	0.89	neutral	0.2	neutral	0	NA	0.75	deleterious	-1.26	low_impact	-0.21	medium_impact	1.21	medium_impact	0.31	0.8	0.29	6.64	0.41	N	0.78	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5074	5074	T	C	MI.14035	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	605	202	I	T	aTt/aCt	-11.02	0	0	benign	0.03	neutral	0.19	neutral	4.46	neutral	-2.33	neutral	-2.36	neutral_impact	0.64	0.97	neutral	0.96	neutral	2.16	17.25	deleterious	0.08	0.35	0.64	disease	0.38	neutral	0.42	neutral	0.61	disease	2	0.8	neutral	0.58	deleterious	-6	neutral	0.20	neutral	0.59	medium_impact	-0.14	medium_impact	-0.61	medium_impact	0.25	0.8	0.29	6.64	0.46	N	0.41	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5074	5074	T	G	MI.14036	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	605	202	I	S	aTt/aGt	-11.02	0	0	benign	0.37	neutral	0.31	neutral	4.47	neutral	-2.89	deleterious	-3.44	low_impact	1.64	0.87	neutral	0.58	neutral	4.30	24.00	deleterious	0.03	0.35	0.53	disease	0.64	disease	0.62	disease	0.69	disease	4	0.63	neutral	0.47	deleterious	-6	neutral	0.53	deleterious	-0.59	medium_impact	0.02	medium_impact	0.24	medium_impact	0.24	0.8	0.29	6.64	0.34	N	0.66	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5075	5075	T	A	MI.14037	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	606	202	I	M	atT/atA	1.41	0	0	possibly_damaging	0.86	neutral	0.13	neutral	4.55	neutral	-1.52	neutral	-0.29	neutral_impact	0.67	0.87	neutral	0.94	neutral	2.48	19.32	deleterious	0.25	0.45	0.62	disease	0.24	neutral	0.34	neutral	0.55	disease	1	0.94	neutral	0.14	neutral	-3	neutral	0.66	deleterious	-1.52	low_impact	-0.25	medium_impact	-0.58	medium_impact	0.59	0.8	0.29	6.64	0.52	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5075	5075	T	G	MI.14038	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	606	202	I	M	atT/atG	1.41	0	0	possibly_damaging	0.86	neutral	0.13	neutral	4.55	neutral	-1.52	neutral	-0.29	neutral_impact	0.67	0.87	neutral	0.94	neutral	2.13	17.03	deleterious	0.25	0.45	0.62	disease	0.24	neutral	0.34	neutral	0.55	disease	1	0.94	neutral	0.14	neutral	-3	neutral	0.66	deleterious	-1.52	low_impact	-0.25	medium_impact	-0.58	medium_impact	0.59	0.8	0.29	6.64	0.52	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5076	5076	C	A	MI.14039	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	607	203	L	I	Ctt/Att	-11.71	0	0	possibly_damaging	0.56	neutral	0.48	neutral	4.69	neutral	0.24	neutral	-1.72	low_impact	1.36	0.9	neutral	0.69	neutral	2.29	18.10	deleterious	0.36	0.5	0.64	disease	0.28	neutral	0.38	neutral	0.53	disease	1	0.56	neutral	0.46	neutral	-3	neutral	0.56	deleterious	-0.89	medium_impact	0.19	medium_impact	0	medium_impact	0.57	0.8	NA	NA	0.36	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9187	9187	T	A	MI.1404	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	661	221	Y	N	Tac/Aac	-14.45	0	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-9.09	deleterious	-7.94	high_impact	4.55	0.43	damaging	0.46	neutral	4.09	23.70	deleterious	0.2	0.65	NA	NA	0.77	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	2.8	high_impact	0.23	0.9	48.67	8.74	0.52	P	1.00	disease_causing	0.84	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5076	5076	C	T	MI.14040	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	607	203	L	F	Ctt/Ttt	-11.71	0	0	benign	0.04	neutral	0.33	neutral	4.55	neutral	-0.6	deleterious	-2.86	low_impact	1.21	0.88	neutral	0.73	neutral	0.91	10.14	neutral	0.29	0.45	0.78	disease	0.47	neutral	0.4	neutral	0.49	neutral	0	0.65	neutral	0.65	deleterious	-6	neutral	0.26	neutral	0.47	medium_impact	0.04	medium_impact	-0.13	medium_impact	0.57	0.8	NA	NA	0.39	N	0.18	polymorphism	1	0.06	rs386828960	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5076	5076	C	G	MI.14041	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	607	203	L	V	Ctt/Gtt	-11.71	0	0	possibly_damaging	0.56	neutral	0.17	neutral	4.49	neutral	-1.21	deleterious	-2.67	medium_impact	1.94	0.94	neutral	0.58	neutral	1.64	14.07	neutral	0.36	0.5	0.57	disease	0.42	neutral	0.54	disease	0.6	disease	2	0.82	neutral	0.31	neutral	0	NA	0.60	deleterious	-0.89	medium_impact	-0.17	medium_impact	0.49	medium_impact	0.68	0.85	NA	NA	0.44	N	0.41	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5077	5077	T	C	MI.14042	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	608	203	L	P	cTt/cCt	-1.81	0	0	probably_damaging	0.95	neutral	0.05	neutral	4.37	deleterious	-4.34	deleterious	-6.39	medium_impact	3.29	0.85	neutral	0.37	neutral	3.72	23.30	deleterious	0.02	0.35	0.38	neutral	0.72	disease	0.74	disease	0.68	disease	4	0.99	deleterious	0.05	neutral	1	deleterious	0.78	deleterious	-1.97	low_impact	-0.5	medium_impact	1.63	medium_impact	0.22	0.8	NA	NA	0.38	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5077	5077	T	A	MI.14043	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	608	203	L	H	cTt/cAt	-1.81	0	0	probably_damaging	0.97	neutral	0.11	neutral	4.37	deleterious	-4.29	deleterious	-6.1	medium_impact	3.29	0.88	neutral	0.36	neutral	3.94	23.50	deleterious	0.04	0.35	0.86	disease	0.68	disease	0.7	disease	0.67	disease	3	0.99	deleterious	0.07	neutral	1	deleterious	0.81	deleterious	-2.18	low_impact	-0.3	medium_impact	1.63	medium_impact	0.21	0.8	NA	NA	0.41	N	0.86	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5077	5077	T	G	MI.14044	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	608	203	L	R	cTt/cGt	-1.81	0	0	probably_damaging	0.93	deleterious	0.04	neutral	4.38	deleterious	-3.75	deleterious	-5.43	high_impact	3.64	0.85	neutral	0.37	neutral	3.93	23.50	deleterious	0.02	0.35	0.79	disease	0.8	disease	0.73	disease	0.68	disease	4	0.99	deleterious	0.06	neutral	6	deleterious	0.84	deleterious	-1.83	low_impact	-0.56	medium_impact	1.92	medium_impact	0.22	0.8	NA	NA	0.37	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5079	5079	A	T	MI.14045	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	610	204	N	Y	Aat/Tat	-5.5	0	0	benign	0.01	neutral	1	neutral	4.72	neutral	1.34	deleterious	-6.25	neutral_impact	0.64	0.91	neutral	0.59	neutral	3.66	23.20	deleterious	0.13	0.4	0.77	disease	0.77	disease	0.65	disease	0.55	disease	1	0.01	neutral	1	deleterious	-6	neutral	0.26	neutral	1.03	medium_impact	1.87	high_impact	-0.61	medium_impact	0.28	0.8	NA	NA	0.23	N	0.62	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5079	5079	A	C	MI.14046	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	610	204	N	H	Aat/Cat	-5.5	0	0	possibly_damaging	0.6	neutral	0.44	neutral	4.81	neutral	0.77	deleterious	-4.04	medium_impact	3.41	0.88	neutral	0.3	neutral	3.09	22.50	deleterious	0.3	0.45	0.85	disease	0.72	disease	0.73	disease	0.66	disease	3	0.61	neutral	0.42	neutral	0	NA	0.69	deleterious	-0.96	medium_impact	0.15	medium_impact	1.73	medium_impact	0.26	0.8	NA	NA	0.34	N	0.62	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5079	5079	A	G	MI.14047	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	610	204	N	D	Aat/Gat	-5.5	0	0	benign	0.31	neutral	0.17	neutral	4.62	neutral	-0.94	deleterious	-4.39	medium_impact	3.41	0.86	neutral	0.46	neutral	3.84	23.40	deleterious	0.46	0.55	0.85	disease	0.65	disease	0.7	disease	0.67	disease	3	0.8	neutral	0.43	neutral	-3	neutral	0.51	deleterious	-0.48	medium_impact	-0.17	medium_impact	1.73	medium_impact	0.35	0.8	NA	NA	0.35	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5080	5080	A	G	MI.14048	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	611	204	N	S	aAt/aGt	2.56	0.11	0	benign	0.02	neutral	0.47	neutral	4.65	neutral	0.12	deleterious	-4.25	medium_impact	2.31	0.91	neutral	0.65	neutral	3.12	22.50	deleterious	0.44	0.55	0.41	neutral	0.63	disease	0.49	neutral	0.16	neutral	7	0.51	neutral	0.73	deleterious	-3	neutral	0.20	neutral	0.75	medium_impact	0.18	medium_impact	0.8	medium_impact	0.46	0.8	NA	NA	0.4	N	0.84	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5080	5080	A	T	MI.14049	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	611	204	N	I	aAt/aTt	2.56	0.11	0	benign	0.35	neutral	0.49	neutral	4.76	neutral	-2.14	deleterious	-7.7	medium_impact	3.41	0.89	neutral	0.56	neutral	3.89	23.50	deleterious	0.14	0.4	0.36	neutral	0.82	disease	0.62	disease	0.67	disease	3	0.43	neutral	0.57	deleterious	-3	neutral	0.54	deleterious	-0.55	medium_impact	0.2	medium_impact	1.73	medium_impact	0.24	0.8	NA	NA	0.45	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9187	9187	T	C	MI.1405	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	661	221	Y	H	Tac/Cac	-14.45	0	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-7.7	deleterious	-4.41	high_impact	4.55	0.53	damaging	0.41	neutral	3.63	23.20	deleterious	0.23	0.65	NA	NA	0.73	disease	0.86	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.8	high_impact	0.27	0.9	48.67	8.74	0.52	N	0.99	polymorphism	0.69	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5080	5080	A	C	MI.14050	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	611	204	N	T	aAt/aCt	2.56	0.11	0	benign	0.01	neutral	0.5	neutral	4.69	neutral	-0.74	deleterious	-5.11	low_impact	0.94	0.84	neutral	0.62	neutral	3.36	22.90	deleterious	0.23	0.45	0.52	disease	0.39	neutral	0.44	neutral	0.33	neutral	3	0.49	neutral	0.75	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.21	medium_impact	-0.35	medium_impact	0.39	0.8	NA	NA	0.34	N	0.82	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5081	5081	T	G	MI.14051	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	612	204	N	K	aaT/aaG	1.87	0.1	0.01	benign	0.25	neutral	0.29	neutral	4.64	neutral	-0.31	deleterious	-5.18	medium_impact	3.41	0.87	neutral	0.38	neutral	4.06	23.70	deleterious	0.29	0.45	0.76	disease	0.79	disease	0.71	disease	0.68	disease	4	0.65	neutral	0.52	deleterious	-3	neutral	0.55	deleterious	-0.36	medium_impact	-0.01	medium_impact	1.73	medium_impact	0.48	0.8	NA	NA	0.41	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5081	5081	T	A	MI.14052	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	612	204	N	K	aaT/aaA	1.87	0.1	0.01	benign	0.25	neutral	0.29	neutral	4.64	neutral	-0.31	deleterious	-5.18	medium_impact	3.41	0.87	neutral	0.38	neutral	4.38	24.10	deleterious	0.29	0.45	0.76	disease	0.79	disease	0.71	disease	0.68	disease	4	0.65	neutral	0.52	deleterious	-3	neutral	0.55	deleterious	-0.36	medium_impact	-0.01	medium_impact	1.73	medium_impact	0.48	0.8	NA	NA	0.41	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5082	5082	T	A	MI.14053	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	613	205	L	M	Tta/Ata	-1.35	0	0.01	probably_damaging	1	neutral	0.32	neutral	4.43	neutral	-1.13	neutral	-1.81	low_impact	1.77	0.96	neutral	0.71	neutral	3.79	23.40	deleterious	0.3	0.45	0.76	disease	0.36	neutral	0.52	disease	0.65	disease	3	1	deleterious	0.16	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	0.03	medium_impact	0.35	medium_impact	0.61	0.8	NA	NA	0.46	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5082	5082	T	G	MI.14054	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	613	205	L	V	Tta/Gta	-1.35	0	0.01	probably_damaging	1	neutral	0.34	neutral	4.34	neutral	-1.9	deleterious	-2.83	medium_impact	2.58	0.89	neutral	0.52	neutral	3.45	23.00	deleterious	0.23	0.45	0.5	neutral	0.42	neutral	0.62	disease	0.46	neutral	1	1	deleterious	0.17	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.05	medium_impact	1.03	medium_impact	0.59	0.8	NA	NA	0.42	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5083	5083	T	G	MI.14055	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	614	205	L	W	tTa/tGa	-1.58	0	0	probably_damaging	1	neutral	0.09	neutral	4.22	deleterious	-5.7	deleterious	-5.67	medium_impact	2.65	0.86	neutral	0.42	neutral	3.73	23.30	deleterious	0.05	0.35	0.75	disease	0.62	disease	0.65	disease	0.66	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.35	medium_impact	1.09	medium_impact	0.25	0.8	NA	NA	0.37	N	0.88	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5083	5083	T	C	MI.14056	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	614	205	L	S	tTa/tCa	-1.58	0	0	probably_damaging	1	neutral	0.5	neutral	4.26	deleterious	-3.49	deleterious	-5.67	high_impact	3.62	0.84	neutral	0.55	neutral	3.75	23.30	deleterious	0.06	0.35	0.86	disease	0.6	disease	0.63	disease	0.66	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.21	medium_impact	1.9	medium_impact	0.26	0.8	NA	NA	0.29	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5084	5084	A	C	MI.14057	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	615	205	L	F	ttA/ttC	3.71	0.33	0.01	probably_damaging	1	neutral	0.68	neutral	4.33	neutral	-2.03	deleterious	-3.78	low_impact	0.84	0.89	neutral	0.66	neutral	3.43	23.00	deleterious	0.26	0.45	0.37	neutral	0.07	neutral	0.42	neutral	0.22	neutral	6	1	deleterious	0.34	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.39	medium_impact	-0.44	medium_impact	0.59	0.8	NA	NA	0.42	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5084	5084	A	T	MI.14058	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	615	205	L	F	ttA/ttT	3.71	0.33	0.01	probably_damaging	1	neutral	0.68	neutral	4.33	neutral	-2.03	deleterious	-3.78	low_impact	0.84	0.89	neutral	0.66	neutral	3.55	23.10	deleterious	0.26	0.45	0.37	neutral	0.07	neutral	0.42	neutral	0.22	neutral	6	1	deleterious	0.34	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.39	medium_impact	-0.44	medium_impact	0.59	0.8	NA	NA	0.42	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5085	5085	A	G	MI.14059	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	616	206	T	A	Act/Gct	-2.04	0	0	benign	0.01	neutral	0.25	neutral	4.66	neutral	0.35	neutral	-0.89	neutral_impact	0.64	0.92	neutral	0.93	neutral	0.43	6.86	deleterious	0.25	0.45	0.4	neutral	0.13	neutral	0.49	neutral	0.31	neutral	4	0.75	neutral	0.62	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	-0.06	medium_impact	-0.61	medium_impact	0.37	0.8	2.02	8.05	0.49	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9187	9187	T	G	MI.1406	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	661	221	Y	D	Tac/Gac	-14.45	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-10.32	deleterious	-8.82	high_impact	4.55	0.55	damaging	0.42	neutral	4.01	23.60	deleterious	0.14	0.65	NA	NA	0.8	disease	0.85	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.8	high_impact	0.26	0.9	48.67	8.74	0.47	N	1.00	disease_causing	0.79	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5085	5085	A	T	MI.14060	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	616	206	T	S	Act/Tct	-2.04	0	0	benign	0.14	neutral	0.41	neutral	4.61	neutral	-0.78	neutral	-1.43	neutral_impact	0.44	0.89	neutral	0.93	neutral	0.45	7.01	deleterious	0.4	0.5	0.7	disease	0.2	neutral	0.38	neutral	0.51	disease	0	0.52	neutral	0.64	deleterious	-6	neutral	0.30	neutral	-0.08	medium_impact	0.12	medium_impact	-0.77	medium_impact	0.45	0.8	2.02	8.05	0.47	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5085	5085	A	C	MI.14061	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	616	206	T	P	Act/Cct	-2.04	0	0	possibly_damaging	0.55	neutral	0.13	neutral	4.58	neutral	-2.32	deleterious	-2.59	medium_impact	2.34	0.8	neutral	0.33	neutral	3.32	22.90	deleterious	0.06	0.35	0.67	disease	0.66	disease	0.65	disease	0.7	disease	4	0.86	neutral	0.29	neutral	0	NA	0.66	deleterious	-0.88	medium_impact	-0.25	medium_impact	0.83	medium_impact	0.35	0.8	2.02	8.05	0.3	N	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5086	5086	C	G	MI.14062	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	617	206	T	S	aCt/aGt	-6.19	0	0	benign	0.14	neutral	0.41	neutral	4.61	neutral	-0.78	neutral	-1.43	neutral_impact	0.44	0.89	neutral	0.93	neutral	0.59	8.08	deleterious	0.4	0.5	0.7	disease	0.2	neutral	0.38	neutral	0.51	disease	0	0.52	neutral	0.64	deleterious	-6	neutral	0.30	neutral	-0.08	medium_impact	0.12	medium_impact	-0.77	medium_impact	0.45	0.8	2.02	8.05	0.42	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5086	5086	C	A	MI.14063	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	617	206	T	N	aCt/aAt	-6.19	0	0	possibly_damaging	0.55	neutral	0.14	neutral	4.59	neutral	-2.03	neutral	-2.41	medium_impact	2.34	0.83	neutral	0.51	neutral	3.54	23.10	deleterious	0.22	0.45	0.82	disease	0.38	neutral	0.53	disease	0.66	disease	3	0.85	neutral	0.3	neutral	0	NA	0.65	deleterious	-0.88	medium_impact	-0.23	medium_impact	0.83	medium_impact	0.51	0.8	2.02	8.05	0.38	N	0.61	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5086	5086	C	T	MI.14064	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	617	206	T	I	aCt/aTt	-6.19	0	0	benign	0.01	neutral	0.62	neutral	4.95	neutral	2.48	neutral	1.53	neutral_impact	-0.72	0.96	neutral	0.98	neutral	-0.54	0.18	neutral	0.1	0.4	0.52	disease	0.2	neutral	0.39	neutral	0.27	neutral	5	0.36	neutral	0.81	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.33	medium_impact	-1.75	low_impact	0.59	0.8	2.02	8.05	0.31	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5088	5088	A	T	MI.14065	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	619	207	I	F	Att/Ttt	-7.57	0	0	possibly_damaging	0.61	neutral	0.58	neutral	4.51	neutral	-0.08	deleterious	-3.17	low_impact	1.6	0.9	neutral	0.46	neutral	3.80	23.40	deleterious	0.15	0.4	0.52	disease	0.72	disease	0.62	disease	0.67	disease	3	0.55	neutral	0.49	deleterious	-3	neutral	0.62	deleterious	-0.98	medium_impact	0.29	medium_impact	0.2	medium_impact	0.49	0.8	NA	NA	0.25	N	0.74	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5088	5088	A	G	MI.14066	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	619	207	I	V	Att/Gtt	-7.57	0	0	benign	0.01	neutral	0.44	neutral	4.58	neutral	0.45	neutral	-0.73	low_impact	1.44	0.97	neutral	0.93	neutral	1.09	11.17	neutral	0.32	0.5	0.46	neutral	0.24	neutral	0.4	neutral	0.44	neutral	1	0.55	neutral	0.72	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.15	medium_impact	0.07	medium_impact	0.46	0.8	NA	NA	0.39	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5088	5088	A	C	MI.14067	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	619	207	I	L	Att/Ctt	-7.57	0	0	benign	0.08	neutral	1	neutral	4.62	neutral	0.01	neutral	-1.05	low_impact	1.07	0.87	neutral	0.96	neutral	0.54	7.73	deleterious	0.19	0.45	0.65	disease	0.19	neutral	0.33	neutral	0.49	neutral	0	0.08	neutral	0.96	deleterious	-6	neutral	0.21	neutral	0.17	medium_impact	1.87	high_impact	-0.24	medium_impact	0.46	0.8	NA	NA	0.3	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5089	5089	T	C	MI.14068	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	620	207	I	T	aTt/aCt	0.49	0	0	benign	0.02	neutral	0.46	neutral	4.72	neutral	-0.26	deleterious	-3.68	low_impact	1.41	0.97	neutral	0.79	neutral	0.42	6.76	deleterious	0.09	0.35	0.65	disease	0.4	neutral	0.39	neutral	0.62	disease	2	0.52	neutral	0.72	deleterious	-6	neutral	0.19	neutral	0.75	medium_impact	0.17	medium_impact	0.04	medium_impact	0.34	0.8	NA	NA	0.37	N	0.67	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5089	5089	T	A	MI.14069	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	620	207	I	N	aTt/aAt	0.49	0	0	possibly_damaging	0.75	neutral	0.37	neutral	4.49	neutral	-1.4	deleterious	-5.68	medium_impact	3.23	0.88	neutral	0.39	neutral	4.27	24.00	deleterious	0.13	0.4	0.41	neutral	0.76	disease	0.6	disease	0.68	disease	4	0.77	neutral	0.31	neutral	0	NA	0.63	deleterious	-1.23	low_impact	0.08	medium_impact	1.57	medium_impact	0.33	0.8	NA	NA	0.35	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9188	9188	A	C	MI.1407	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	662	221	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	neutral	0.08	neutral	2.63	deleterious	-9.01	deleterious	-7.93	high_impact	4.21	0.47	damaging	0.59	neutral	4.53	24.30	deleterious	0.18	0.65	NA	NA	0.77	disease	0.78	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.31	medium_impact	2.51	high_impact	0.26	0.9	48.67	8.74	0.52	P	0.99	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5089	5089	T	G	MI.14070	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	620	207	I	S	aTt/aGt	0.49	0	0	benign	0.29	neutral	0.48	neutral	4.66	neutral	-0.61	deleterious	-4.73	medium_impact	2.25	0.89	neutral	0.46	neutral	3.75	23.30	deleterious	0.05	0.35	0.68	disease	0.75	disease	0.58	disease	0.67	disease	3	0.42	neutral	0.6	deleterious	-3	neutral	0.55	deleterious	-0.44	medium_impact	0.19	medium_impact	0.75	medium_impact	0.26	0.8	NA	NA	0.34	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5090	5090	T	A	MI.14071	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	621	207	I	M	atT/atA	1.41	0	0	benign	0.06	neutral	0.34	neutral	4.53	neutral	-1.47	neutral	-1.75	low_impact	1.81	0.94	neutral	0.88	neutral	2.38	18.70	deleterious	0.28	0.45	0.61	disease	0.38	neutral	0.38	neutral	0.61	disease	2	0.63	neutral	0.64	deleterious	-6	neutral	0.25	neutral	0.3	medium_impact	0.05	medium_impact	0.38	medium_impact	0.51	0.8	NA	NA	0.43	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5090	5090	T	G	MI.14072	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	621	207	I	M	atT/atG	1.41	0	0	benign	0.06	neutral	0.34	neutral	4.53	neutral	-1.47	neutral	-1.75	low_impact	1.81	0.94	neutral	0.88	neutral	2.16	17.27	deleterious	0.28	0.45	0.61	disease	0.38	neutral	0.38	neutral	0.61	disease	2	0.63	neutral	0.64	deleterious	-6	neutral	0.25	neutral	0.3	medium_impact	0.05	medium_impact	0.38	medium_impact	0.51	0.8	NA	NA	0.43	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5091	5091	T	G	MI.14073	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	622	208	Y	D	Tat/Gat	-16.09	0	0	probably_damaging	1	neutral	0.16	neutral	4.28	deleterious	-5.59	deleterious	-9.53	high_impact	4.11	0.89	neutral	0.13	damaging	3.98	23.60	deleterious	0.04	0.35	0.79	disease	0.86	disease	0.82	disease	0.68	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.19	medium_impact	2.32	high_impact	0.17	0.8	NA	NA	0.49	N	0.96	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5091	5091	T	C	MI.14074	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	622	208	Y	H	Tat/Cat	-16.09	0	0	probably_damaging	1	neutral	0.3	neutral	5.04	neutral	1.26	deleterious	-4.77	high_impact	3.56	0.85	neutral	0.11	damaging	3.58	23.20	deleterious	0.11	0.4	0.66	disease	0.82	disease	0.78	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	0	medium_impact	1.85	medium_impact	0.23	0.8	NA	NA	0.34	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5091	5091	T	A	MI.14075	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	622	208	Y	N	Tat/Aat	-16.09	0	0	probably_damaging	1	neutral	0.25	neutral	4.29	deleterious	-4.97	deleterious	-8.58	high_impact	3.76	0.87	neutral	0.14	damaging	4.04	23.70	deleterious	0.06	0.35	0.68	disease	0.84	disease	0.76	disease	0.7	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.06	medium_impact	2.02	high_impact	0.20	0.8	NA	NA	0.4	N	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5092	5092	A	G	MI.14076	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	623	208	Y	C	tAt/tGt	4.63	1	0	probably_damaging	1	neutral	0.09	neutral	4.28	deleterious	-6.39	deleterious	-8.58	high_impact	4.11	0.89	neutral	0.11	damaging	3.57	23.10	deleterious	0.06	0.35	0.9	disease	0.86	disease	0.81	disease	0.64	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.35	medium_impact	2.32	high_impact	0.15	0.8	NA	NA	0.66	P	1.00	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5092	5092	A	C	MI.14077	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	623	208	Y	S	tAt/tCt	4.63	1	0	probably_damaging	1	neutral	0.33	neutral	4.29	deleterious	-4.51	deleterious	-8.58	high_impact	4.11	0.85	neutral	0.16	damaging	3.75	23.30	deleterious	0.07	0.35	0.48	neutral	0.84	disease	0.76	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.04	medium_impact	2.32	high_impact	0.25	0.8	NA	NA	0.59	P	0.96	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5092	5092	A	T	MI.14078	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	623	208	Y	F	tAt/tTt	4.63	1	0	probably_damaging	1	neutral	0.54	neutral	4.44	neutral	-1.29	deleterious	-3.82	high_impact	3.76	0.83	neutral	0.11	damaging	3.42	23.00	deleterious	0.14	0.4	0.81	disease	0.82	disease	0.73	disease	0.68	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.25	medium_impact	2.02	high_impact	0.42	0.8	NA	NA	0.53	P	0.80	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5094	5094	A	C	MI.14079	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	625	209	I	L	Att/Ctt	-6.19	0	0	benign	0.09	neutral	0.47	neutral	4.65	neutral	0.31	neutral	-1.38	low_impact	1.17	0.84	neutral	0.88	neutral	2.45	19.14	deleterious	0.18	0.45	0.45	neutral	0.4	neutral	0.29	neutral	0.47	neutral	1	0.46	neutral	0.69	deleterious	-6	neutral	0.19	neutral	0.12	medium_impact	0.18	medium_impact	-0.16	medium_impact	0.59	0.8	NA	NA	0.35	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9188	9188	A	T	MI.1408	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	662	221	Y	F	tAc/tTc	7.53	1	0	probably_damaging	0.99	deleterious	0.02	neutral	2.72	deleterious	-3.69	deleterious	-3.53	medium_impact	3.13	0.51	damaging	0.43	neutral	4.30	24.00	deleterious	0.2	0.65	NA	NA	0.69	disease	0.75	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-2.65	low_impact	-0.66	medium_impact	1.59	medium_impact	0.40	0.9	48.67	8.74	0.53	P	0.81	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5094	5094	A	T	MI.14080	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	625	209	I	F	Att/Ttt	-6.19	0	0	probably_damaging	0.93	neutral	0.52	neutral	4.55	neutral	-2.49	deleterious	-3.49	low_impact	1.47	0.9	neutral	0.66	neutral	3.51	23.10	deleterious	0.16	0.45	0.58	disease	0.71	disease	0.38	neutral	0.19	neutral	6	0.92	neutral	0.3	neutral	-2	neutral	0.71	deleterious	-1.83	low_impact	0.23	medium_impact	0.09	medium_impact	0.50	0.8	NA	NA	0.3	N	0.48	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5094	5094	A	G	MI.14081	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	625	209	I	V	Att/Gtt	-6.19	0	0	possibly_damaging	0.67	neutral	0.37	neutral	4.64	neutral	-0.3	neutral	-0.89	low_impact	1.66	0.94	neutral	0.84	neutral	1.84	15.21	deleterious	0.32	0.5	0.47	neutral	0.28	neutral	0.37	neutral	0.44	neutral	1	0.71	neutral	0.35	neutral	-3	neutral	0.56	deleterious	-1.08	low_impact	0.08	medium_impact	0.25	medium_impact	0.45	0.8	NA	NA	0.45	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5095	5095	T	C	MI.14082	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	626	209	I	T	aTt/aCt	-2.04	0	0	probably_damaging	0.94	neutral	0.37	neutral	4.56	neutral	-1.66	deleterious	-4.42	low_impact	1.38	0.94	neutral	0.6	neutral	3.39	23.00	deleterious	0.11	0.4	0.37	neutral	0.39	neutral	0.54	disease	0.47	neutral	1	0.94	neutral	0.22	neutral	-2	neutral	0.65	deleterious	-1.89	low_impact	0.08	medium_impact	0.02	medium_impact	0.27	0.8	NA	NA	0.39	N	0.68	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5095	5095	T	A	MI.14083	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	626	209	I	N	aTt/aAt	-2.04	0	0	probably_damaging	0.98	neutral	0.2	neutral	4.56	deleterious	-3.69	deleterious	-6.3	medium_impact	3.4	0.89	neutral	0.4	neutral	4.40	24.10	deleterious	0.08	0.35	0.76	disease	0.77	disease	0.56	disease	0.67	disease	3	0.99	deleterious	0.11	neutral	1	deleterious	0.76	deleterious	-2.34	low_impact	-0.13	medium_impact	1.72	medium_impact	0.32	0.8	NA	NA	0.43	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5095	5095	T	G	MI.14084	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	626	209	I	S	aTt/aGt	-2.04	0	0	probably_damaging	0.97	neutral	0.4	neutral	4.58	neutral	-1.38	deleterious	-5.35	low_impact	0.98	0.82	neutral	0.53	neutral	4.30	24.00	deleterious	0.06	0.35	0.58	disease	0.65	disease	0.54	disease	0.38	neutral	2	0.97	neutral	0.22	neutral	-2	neutral	0.71	deleterious	-2.18	low_impact	0.11	medium_impact	-0.32	medium_impact	0.28	0.8	NA	NA	0.26	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5096	5096	T	A	MI.14085	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	627	209	I	M	atT/atA	2.1	0.02	0	probably_damaging	0.96	neutral	0.28	neutral	4.57	neutral	-1.2	neutral	-2.26	low_impact	1.13	0.89	neutral	0.8	neutral	3.65	23.20	deleterious	0.22	0.45	0.57	disease	0.5	disease	0.32	neutral	0.26	neutral	5	0.97	neutral	0.16	neutral	-2	neutral	0.68	deleterious	-2.06	low_impact	-0.02	medium_impact	-0.19	medium_impact	0.51	0.8	NA	NA	0.42	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5096	5096	T	G	MI.14086	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	627	209	I	M	atT/atG	2.1	0.02	0	probably_damaging	0.96	neutral	0.28	neutral	4.57	neutral	-1.2	neutral	-2.26	low_impact	1.13	0.89	neutral	0.8	neutral	3.33	22.90	deleterious	0.22	0.45	0.57	disease	0.5	disease	0.32	neutral	0.26	neutral	5	0.97	neutral	0.16	neutral	-2	neutral	0.68	deleterious	-2.06	low_impact	-0.02	medium_impact	-0.19	medium_impact	0.51	0.8	NA	NA	0.42	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5097	5097	A	G	MI.14087	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	628	210	I	V	Atc/Gtc	-10.79	0	0	benign	0	neutral	0.45	neutral	4.7	neutral	-0.32	neutral	-0.44	low_impact	1.22	0.96	neutral	0.92	neutral	-0.09	1.83	neutral	0.28	0.45	0.69	disease	0.19	neutral	0.37	neutral	0.5	neutral	0	0.54	neutral	0.73	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.16	medium_impact	-0.12	medium_impact	0.53	0.8	NA	NA	0.39	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5097	5097	A	C	MI.14088	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	628	210	I	L	Atc/Ctc	-10.79	0	0	benign	0.01	neutral	0.99	neutral	4.84	neutral	0.62	neutral	0.22	neutral_impact	0.54	0.87	neutral	0.97	neutral	-0.46	0.28	neutral	0.16	0.45	0.45	neutral	0.17	neutral	0.3	neutral	0.25	neutral	5	0	neutral	0.99	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	1.32	medium_impact	-0.69	medium_impact	0.52	0.8	NA	NA	0.35	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5097	5097	A	T	MI.14089	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	628	210	I	F	Atc/Ttc	-10.79	0	0	benign	0.01	neutral	0.87	neutral	4.89	neutral	-0.11	neutral	-1.92	neutral_impact	0.59	0.88	neutral	0.96	neutral	0.83	9.64	deleterious	0.14	0.4	0.72	disease	0.58	disease	0.39	neutral	0.25	neutral	5	0.1	neutral	0.93	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	0.67	medium_impact	-0.65	medium_impact	0.54	0.8	NA	NA	0.28	N	0.31	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9188	9188	A	G	MI.1409	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	662	221	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-10.51	deleterious	-7.96	high_impact	4.55	0.42	damaging	0.33	neutral	4.38	24.10	deleterious	0.23	0.65	NA	NA	0.78	disease	0.83	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.8	high_impact	0.21	0.9	48.67	8.74	0.6	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5098	5098	T	G	MI.14090	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	629	210	I	S	aTc/aGc	-1.35	0	0	benign	0.14	neutral	0.62	neutral	4.61	neutral	-2.55	deleterious	-3.18	low_impact	1.56	0.86	neutral	0.72	neutral	1.26	12.05	neutral	0.05	0.35	0.91	disease	0.65	disease	0.59	disease	0.7	disease	4	0.27	neutral	0.74	deleterious	-6	neutral	0.36	neutral	-0.08	medium_impact	0.33	medium_impact	0.17	medium_impact	0.25	0.8	NA	NA	0.21	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5098	5098	T	A	MI.14091	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	629	210	I	N	aTc/aAc	-1.35	0	0	benign	0.39	neutral	0.23	neutral	4.55	deleterious	-4.03	deleterious	-4.16	medium_impact	2.19	0.89	neutral	0.41	neutral	2.61	20.30	deleterious	0.1	0.4	0.96	disease	0.71	disease	0.6	disease	0.7	disease	4	0.73	neutral	0.42	neutral	-3	neutral	0.64	deleterious	-0.62	medium_impact	-0.08	medium_impact	0.7	medium_impact	0.27	0.8	NA	NA	0.42	N	0.83	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5098	5098	T	C	MI.14092	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	629	210	I	T	aTc/aCc	-1.35	0	0	benign	0.01	neutral	0.57	neutral	4.61	neutral	-2.18	neutral	-2.13	neutral_impact	0.78	0.93	neutral	0.98	neutral	-0.18	1.21	neutral	0.1	0.4	0.73	disease	0.27	neutral	0.4	neutral	0.58	disease	2	0.41	neutral	0.78	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.28	medium_impact	-0.49	medium_impact	0.25	0.8	NA	NA	0.33	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5099	5099	C	G	MI.14093	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	630	210	I	M	atC/atG	-0.2	0	0.01	possibly_damaging	0.66	neutral	0.79	neutral	4.6	neutral	-1.94	neutral	-0.15	neutral_impact	0.56	0.93	neutral	0.95	neutral	-0.27	0.78	neutral	0.22	0.45	0.7	disease	0.2	neutral	0.32	neutral	0.51	disease	0	0.59	neutral	0.57	deleterious	-3	neutral	0.58	deleterious	-1.06	low_impact	0.53	medium_impact	-0.67	medium_impact	0.59	0.8	NA	NA	0.35	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5099	5099	C	A	MI.14094	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	630	210	I	M	atC/atA	-0.2	0	0.01	possibly_damaging	0.66	neutral	0.79	neutral	4.6	neutral	-1.94	neutral	-0.15	neutral_impact	0.56	0.93	neutral	0.95	neutral	0.20	4.71	deleterious	0.22	0.45	0.7	disease	0.2	neutral	0.32	neutral	0.51	disease	0	0.59	neutral	0.57	deleterious	-3	neutral	0.58	deleterious	-1.06	low_impact	0.53	medium_impact	-0.67	medium_impact	0.59	0.8	NA	NA	0.35	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5100	5100	C	G	MI.14095	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	631	211	L	V	Cta/Gta	-6.88	0	0.01	benign	0.41	neutral	0.44	neutral	4.65	neutral	0.29	neutral	-1.52	low_impact	0.84	0.88	neutral	0.67	neutral	3.41	23.00	deleterious	0.27	0.45	0.79	disease	0.41	neutral	0.57	disease	0.68	disease	4	0.5	neutral	0.52	deleterious	-6	neutral	0.64	deleterious	-0.65	medium_impact	0.15	medium_impact	-0.44	medium_impact	0.44	0.8	6.92	8.08	0.31	N	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5100	5100	C	A	MI.14096	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	631	211	L	M	Cta/Ata	-6.88	0	0.01	benign	0.3	neutral	1	neutral	4.65	neutral	0.58	neutral	1.09	neutral_impact	-1.22	0.93	neutral	0.9	neutral	1.01	10.74	neutral	0.26	0.45	0.79	disease	0.02	neutral	0.23	neutral	0.37	neutral	3	0.3	neutral	0.85	deleterious	-6	neutral	0.48	deleterious	-0.46	medium_impact	1.87	high_impact	-2.17	low_impact	0.39	0.8	6.92	8.08	0.3	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5101	5101	T	C	MI.14097	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	632	211	L	P	cTa/cCa	0.26	0	0	probably_damaging	0.97	neutral	0.21	neutral	4.53	deleterious	-3.77	deleterious	-4.64	medium_impact	1.96	0.73	neutral	0.37	neutral	3.94	23.50	deleterious	0.03	0.35	0.78	disease	0.86	disease	0.7	disease	0.72	disease	4	0.98	neutral	0.12	neutral	1	deleterious	0.87	deleterious	-2.18	low_impact	-0.11	medium_impact	0.51	medium_impact	0.26	0.8	6.92	8.08	0.27	N	0.92	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5101	5101	T	A	MI.14098	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	632	211	L	Q	cTa/cAa	0.26	0	0	probably_damaging	0.95	neutral	0.14	neutral	4.53	neutral	-2.16	deleterious	-3.14	medium_impact	2.31	0.86	neutral	0.52	neutral	4.11	23.80	deleterious	0.04	0.35	0.96	disease	0.63	disease	0.57	disease	0.79	disease	6	0.98	neutral	0.1	neutral	1	deleterious	0.83	deleterious	-1.97	low_impact	-0.23	medium_impact	0.8	medium_impact	0.20	0.8	6.92	8.08	0.36	N	0.87	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5101	5101	T	G	MI.14099	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	632	211	L	R	cTa/cGa	0.26	0	0	probably_damaging	0.95	neutral	0.2	neutral	4.54	deleterious	-3.16	deleterious	-3.72	medium_impact	2.31	0.81	neutral	0.46	neutral	4.18	23.80	deleterious	0.03	0.35	0.96	disease	0.88	disease	0.69	disease	0.68	disease	4	0.97	neutral	0.13	neutral	1	deleterious	0.90	deleterious	-1.97	low_impact	-0.13	medium_impact	0.8	medium_impact	0.15	0.8	6.92	8.08	0.29	N	0.90	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8593	8593	A	C	MI.141	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	67	23	I	L	Atc/Ctc	-8.2	0	0	benign	0.09	neutral	0.66	neutral	4.63	neutral	1.49	neutral	-1.09	neutral_impact	0.47	0.89	neutral	0.4	neutral	0.64	8.43	deleterious	0.35	0.65	0.46	neutral	0.46	neutral	0.38	neutral	0.48	neutral	0	0.24	neutral	0.79	deleterious	-6	neutral	0.22	neutral	0.2	medium_impact	0.45	medium_impact	-0.7	medium_impact	0.56	0.9	19.03	10.37	0.34	N	0.67	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9190	9190	C	A	MI.1410	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	664	222	L	M	Ctg/Atg	-1.95	0	0	probably_damaging	1	neutral	0.05	neutral	4.09	neutral	-2.89	neutral	-1.76	medium_impact	2.65	0.65	neutral	0.19	damaging	4.10	23.70	deleterious	0.46	0.65	NA	NA	0.25	neutral	0.43	neutral	0.19	neutral	6	1	deleterious	0.03	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	-0.43	medium_impact	1.17	medium_impact	0.75	0.9	51.33	8.07	0.38	N	0.96	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5103	5103	A	C	MI.14100	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	634	212	T	P	Act/Cct	-2.04	0	0	probably_damaging	0.98	neutral	0.22	neutral	4.57	deleterious	-3.65	deleterious	-5.72	high_impact	3.84	0.75	neutral	0.52	neutral	3.51	23.10	deleterious	0.05	0.35	0.68	disease	0.83	disease	0.81	disease	0.72	disease	4	0.99	deleterious	0.12	neutral	2	deleterious	0.76	deleterious	-2.34	low_impact	-0.1	medium_impact	2.09	high_impact	0.26	0.8	NA	NA	0.44	N	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5103	5103	A	T	MI.14101	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	634	212	T	S	Act/Tct	-2.04	0	0	probably_damaging	0.91	neutral	0.53	neutral	4.81	neutral	-0.31	deleterious	-3.82	low_impact	1.6	0.86	neutral	0.68	neutral	3.33	22.90	deleterious	0.29	0.45	0.68	disease	0.69	disease	0.61	disease	0.64	disease	3	0.9	neutral	0.31	neutral	-2	neutral	0.75	deleterious	-1.72	low_impact	0.24	medium_impact	0.2	medium_impact	0.43	0.8	NA	NA	0.23	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5103	5103	A	G	MI.14102	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	634	212	T	A	Act/Gct	-2.04	0	0	possibly_damaging	0.7	neutral	0.52	neutral	4.63	neutral	-1.19	deleterious	-4.77	medium_impact	2.6	0.83	neutral	0.65	neutral	3.53	23.10	deleterious	0.19	0.45	0.58	disease	0.58	disease	0.65	disease	0.63	disease	3	0.67	neutral	0.41	neutral	0	NA	0.68	deleterious	-1.13	low_impact	0.23	medium_impact	1.04	medium_impact	0.30	0.8	NA	NA	0.26	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5104	5104	C	G	MI.14103	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	635	212	T	S	aCt/aGt	8.55	1	0	probably_damaging	0.91	neutral	0.53	neutral	4.81	neutral	-0.31	deleterious	-3.82	low_impact	1.6	0.86	neutral	0.68	neutral	3.47	23.00	deleterious	0.29	0.45	0.68	disease	0.69	disease	0.61	disease	0.64	disease	3	0.9	neutral	0.31	neutral	-2	neutral	0.75	deleterious	-1.72	low_impact	0.24	medium_impact	0.2	medium_impact	0.43	0.8	NA	NA	0.54	P	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5104	5104	C	A	MI.14104	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	635	212	T	N	aCt/aAt	8.55	1	0	probably_damaging	0.98	neutral	0.35	neutral	4.65	neutral	-0.31	deleterious	-4.77	medium_impact	2.13	0.87	neutral	0.59	neutral	3.71	23.30	deleterious	0.25	0.45	0.76	disease	0.81	disease	0.65	disease	0.65	disease	3	0.98	deleterious	0.19	neutral	1	deleterious	0.77	deleterious	-2.34	low_impact	0.06	medium_impact	0.65	medium_impact	0.49	0.8	NA	NA	0.63	P	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5104	5104	C	T	MI.14105	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	635	212	T	I	aCt/aTt	8.55	1	0	possibly_damaging	0.8	neutral	0.49	neutral	4.59	neutral	-2.71	deleterious	-5.72	medium_impact	2.15	0.9	neutral	0.67	neutral	3.87	23.50	deleterious	0.12	0.4	0.66	disease	0.84	disease	0.67	disease	0.69	disease	4	0.78	neutral	0.35	neutral	0	NA	0.73	deleterious	-1.35	low_impact	0.2	medium_impact	0.67	medium_impact	0.50	0.8	NA	NA	0.62	P	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5106	5106	A	G	MI.14106	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	637	213	T	A	Act/Gct	-10.33	0	0	benign	0.42	neutral	0.53	neutral	4.83	neutral	1.45	neutral	-1.31	neutral_impact	0.41	0.88	neutral	0.85	neutral	2.32	18.30	deleterious	0.26	0.45	0.41	neutral	0.12	neutral	0.33	neutral	0.28	neutral	4	0.43	neutral	0.56	deleterious	-6	neutral	0.42	neutral	-0.67	medium_impact	0.24	medium_impact	-0.8	medium_impact	0.32	0.8	3.46	8.17	0.42	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5106	5106	A	C	MI.14107	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	637	213	T	P	Act/Cct	-10.33	0	0	possibly_damaging	0.9	neutral	0.21	neutral	4.54	neutral	-2.95	deleterious	-2.97	medium_impact	2.46	0.79	neutral	0.35	neutral	3.48	23.10	deleterious	0.06	0.35	0.8	disease	0.81	disease	0.6	disease	0.65	disease	3	0.93	neutral	0.16	neutral	0	NA	0.79	deleterious	-1.67	low_impact	-0.11	medium_impact	0.93	medium_impact	0.47	0.8	3.46	8.17	0.29	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5106	5106	A	T	MI.14108	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	637	213	T	S	Act/Tct	-10.33	0	0	benign	0.06	neutral	0.44	neutral	4.71	neutral	0.65	neutral	-1.29	neutral_impact	-0.26	0.96	neutral	0.98	neutral	1.66	14.17	neutral	0.41	0.5	0.48	neutral	0.13	neutral	0.25	neutral	0.26	neutral	5	0.51	neutral	0.69	deleterious	-6	neutral	0.17	neutral	0.3	medium_impact	0.15	medium_impact	-1.36	low_impact	0.58	0.8	3.46	8.17	0.38	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5107	5107	C	G	MI.14109	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	638	213	T	S	aCt/aGt	-5.73	0	0	benign	0.06	neutral	0.44	neutral	4.71	neutral	0.65	neutral	-1.29	neutral_impact	-0.26	0.96	neutral	0.98	neutral	1.82	15.12	deleterious	0.41	0.5	0.48	neutral	0.13	neutral	0.25	neutral	0.26	neutral	5	0.51	neutral	0.69	deleterious	-6	neutral	0.17	neutral	0.3	medium_impact	0.15	medium_impact	-1.36	low_impact	0.58	0.8	3.46	8.17	0.44	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9190	9190	C	G	MI.1411	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	664	222	L	V	Ctg/Gtg	-1.95	0	0	probably_damaging	0.99	neutral	0.06	neutral	4.09	neutral	-1.38	deleterious	-2.63	medium_impact	2.78	0.61	neutral	0.17	damaging	3.69	23.30	deleterious	0.4	0.65	NA	NA	0.28	neutral	0.47	neutral	0.19	neutral	6	1	deleterious	0.04	neutral	1	deleterious	0.75	deleterious	-2.65	low_impact	-0.38	medium_impact	1.29	medium_impact	0.48	0.9	51.33	8.07	0.36	N	0.87	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5107	5107	C	A	MI.14110	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	638	213	T	N	aCt/aAt	-5.73	0	0	possibly_damaging	0.67	neutral	0.32	neutral	4.55	neutral	-2.46	neutral	-2.5	medium_impact	2.12	0.85	neutral	0.52	neutral	3.57	23.10	deleterious	0.25	0.45	0.47	neutral	0.58	disease	0.45	neutral	0.42	neutral	2	0.74	neutral	0.33	neutral	0	NA	0.59	deleterious	-1.08	low_impact	0.03	medium_impact	0.64	medium_impact	0.51	0.8	3.46	8.17	0.33	N	0.52	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5107	5107	C	T	MI.14111	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	638	213	T	I	aCt/aTt	-5.73	0	0	benign	0.06	neutral	0.4	neutral	4.68	neutral	0.36	neutral	0.15	neutral_impact	0.33	0.9	neutral	0.97	neutral	1.75	14.67	neutral	0.13	0.4	0.83	disease	0.46	neutral	0.31	neutral	0.6	disease	2	0.56	neutral	0.67	deleterious	-6	neutral	0.24	neutral	0.3	medium_impact	0.11	medium_impact	-0.87	medium_impact	0.62	0.8	3.46	8.17	0.37	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5109	5109	A	T	MI.14112	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	640	214	T	S	Acc/Tcc	-7.57	0	0	benign	0.07	neutral	0.53	neutral	4.59	neutral	-0.7	neutral	-1.1	neutral_impact	0.33	0.86	neutral	0.98	neutral	0.42	6.78	deleterious	0.36	0.5	0.52	disease	0.23	neutral	0.28	neutral	0.36	neutral	3	0.4	neutral	0.73	deleterious	-6	neutral	0.21	neutral	0.23	medium_impact	0.24	medium_impact	-0.87	medium_impact	0.67	0.85	NA	NA	0.33	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5109	5109	A	G	MI.14113	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	640	214	T	A	Acc/Gcc	-7.57	0	0	benign	0.02	neutral	0.63	neutral	4.61	neutral	1.13	neutral	-2.08	neutral_impact	0.44	0.94	neutral	0.99	neutral	0.71	8.91	deleterious	0.19	0.45	0.61	disease	0.12	neutral	0.35	neutral	0.32	neutral	4	0.33	neutral	0.81	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.34	medium_impact	-0.77	medium_impact	0.34	0.8	NA	NA	0.27	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5109	5109	A	C	MI.14114	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	640	214	T	P	Acc/Ccc	-7.57	0	0	possibly_damaging	0.73	neutral	0.25	neutral	4.49	neutral	-2.97	deleterious	-2.68	low_impact	1.02	0.9	neutral	0.95	neutral	2.49	19.42	deleterious	0.1	0.4	0.68	disease	0.83	disease	0.48	neutral	0.23	neutral	5	0.82	neutral	0.26	neutral	-3	neutral	0.78	deleterious	-1.19	low_impact	-0.06	medium_impact	-0.29	medium_impact	0.31	0.8	NA	NA	0.41	N	0.41	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5110	5110	C	T	MI.14115	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	641	214	T	I	aCc/aTc	-2.27	0	0	possibly_damaging	0.66	neutral	0.46	neutral	4.6	neutral	-0.37	deleterious	-3.9	low_impact	1.54	0.87	neutral	0.49	neutral	3.59	23.20	deleterious	0.14	0.4	0.43	neutral	0.75	disease	0.55	disease	0.66	disease	3	0.65	neutral	0.4	neutral	-3	neutral	0.68	deleterious	-1.06	low_impact	0.17	medium_impact	0.15	medium_impact	0.59	0.8	NA	NA	0.26	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5110	5110	C	G	MI.14116	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	641	214	T	S	aCc/aGc	-2.27	0	0	benign	0.07	neutral	0.53	neutral	4.59	neutral	-0.7	neutral	-1.1	neutral_impact	0.33	0.86	neutral	0.98	neutral	0.10	3.56	deleterious	0.36	0.5	0.52	disease	0.23	neutral	0.28	neutral	0.36	neutral	3	0.4	neutral	0.73	deleterious	-6	neutral	0.21	neutral	0.23	medium_impact	0.24	medium_impact	-0.87	medium_impact	0.67	0.85	NA	NA	0.33	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5110	5110	C	A	MI.14117	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	641	214	T	N	aCc/aAc	-2.27	0	0	possibly_damaging	0.66	neutral	0.38	neutral	4.51	neutral	-1.76	neutral	-2.18	low_impact	1.78	0.91	neutral	0.63	neutral	3.37	22.90	deleterious	0.25	0.45	0.87	disease	0.75	disease	0.57	disease	0.67	disease	3	0.69	neutral	0.36	neutral	-3	neutral	0.71	deleterious	-1.06	low_impact	0.09	medium_impact	0.35	medium_impact	0.45	0.8	NA	NA	0.34	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5112	5112	G	C	MI.14118	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	643	215	A	P	Gca/Cca	-14.47	0	0	benign	0.33	neutral	0.15	neutral	4.57	neutral	-2.69	neutral	-1.34	neutral_impact	0.7	0.85	neutral	0.38	neutral	2.25	17.81	deleterious	0.04	0.35	0.83	disease	0.82	disease	0.69	disease	0.72	disease	4	0.82	neutral	0.41	neutral	-6	neutral	0.60	deleterious	-0.52	medium_impact	-0.21	medium_impact	-0.56	medium_impact	0.46	0.8	2.02	7.82	0.27	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5112	5112	G	T	MI.14119	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	643	215	A	S	Gca/Tca	-14.47	0	0	benign	0.02	neutral	0.38	neutral	4.62	neutral	-0.36	neutral	0.1	neutral_impact	0.7	0.8	neutral	0.81	neutral	1.79	14.90	neutral	0.3	0.45	0.65	disease	0.4	neutral	0.52	disease	0.63	disease	3	0.6	neutral	0.68	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	0.09	medium_impact	-0.56	medium_impact	0.31	0.8	2.02	7.82	0.37	N	0.56	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9191	9191	T	A	MI.1412	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	665	222	L	Q	cTg/cAg	-2.65	0	0	probably_damaging	1	deleterious	0.02	neutral	3.99	deleterious	-5.72	deleterious	-5.28	high_impact	3.75	0.45	damaging	0.15	damaging	4.51	24.30	deleterious	0.27	0.65	NA	NA	0.58	disease	0.59	disease	0.64	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.6	low_impact	-0.66	medium_impact	2.12	high_impact	0.50	0.9	51.33	8.07	0.34	N	0.98	polymorphism	0.87	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5112	5112	G	A	MI.14120	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	643	215	A	T	Gca/Aca	-14.47	0	0	benign	0	neutral	0.4	neutral	4.64	neutral	0.01	neutral	1.07	neutral_impact	-0.83	0.94	neutral	0.98	neutral	-0.06	2.01	deleterious	0.18	0.45	0.54	disease	0.15	neutral	0.28	neutral	0.3	neutral	4	0.6	neutral	0.7	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.11	medium_impact	-1.84	low_impact	0.80	0.85	2.02	7.82	0.4	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5113	5113	C	A	MI.14121	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	644	215	A	E	gCa/gAa	-2.04	0	0	benign	0.17	neutral	0.19	neutral	4.57	neutral	-2.33	neutral	-1.3	low_impact	1.8	0.91	neutral	0.6	neutral	2.71	20.90	deleterious	0.03	0.35	0.77	disease	0.75	disease	0.67	disease	0.72	disease	4	0.78	neutral	0.51	deleterious	-6	neutral	0.37	neutral	-0.17	medium_impact	-0.14	medium_impact	0.37	medium_impact	0.28	0.8	2.02	7.82	0.36	N	0.80	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5113	5113	C	G	MI.14122	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	644	215	A	G	gCa/gGa	-2.04	0	0	benign	0.13	neutral	0.26	neutral	4.57	neutral	-2.17	neutral	-2.06	low_impact	1.46	0.89	neutral	0.6	neutral	2.12	16.96	deleterious	0.23	0.45	0.78	disease	0.44	neutral	0.54	disease	0.67	disease	3	0.7	neutral	0.57	deleterious	-6	neutral	0.28	neutral	-0.04	medium_impact	-0.04	medium_impact	0.09	medium_impact	0.50	0.8	2.02	7.82	0.42	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5113	5113	C	T	MI.14123	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	644	215	A	V	gCa/gTa	-2.04	0	0	benign	0.05	neutral	0.49	neutral	4.71	neutral	0.79	neutral	0.73	neutral_impact	-0.44	0.8	neutral	0.8	neutral	1.31	12.30	neutral	0.2	0.45	0.44	neutral	0.16	neutral	0.34	neutral	0.3	neutral	4	0.46	neutral	0.72	deleterious	-6	neutral	0.16	neutral	0.37	medium_impact	0.2	medium_impact	-1.52	low_impact	0.72	0.85	2.02	7.82	0.31	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5115	5115	T	C	MI.14124	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	646	216	F	L	Ttc/Ctc	-1.12	0	0	benign	0.09	neutral	0.59	neutral	2.74	deleterious	-5.12	deleterious	-5.52	medium_impact	2.1	0.92	neutral	0.22	damaging	4.06	23.70	deleterious	0.15	0.4	0.12	neutral	0.8	disease	0.68	disease	0.55	disease	1	0.32	neutral	0.75	deleterious	-3	neutral	0.27	neutral	0.12	medium_impact	0.3	medium_impact	0.62	medium_impact	0.36	0.8	0.29	7.08	0.26	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5115	5115	T	A	MI.14125	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	646	216	F	I	Ttc/Atc	-1.12	0	0	possibly_damaging	0.77	neutral	0.48	neutral	2.65	deleterious	-7.21	deleterious	-5.57	low_impact	1.63	0.91	neutral	0.13	damaging	4.44	24.20	deleterious	0.15	0.4	0.43	neutral	0.79	disease	0.75	disease	0.68	disease	4	0.75	neutral	0.36	neutral	-3	neutral	0.73	deleterious	-1.28	low_impact	0.19	medium_impact	0.23	medium_impact	0.39	0.8	0.29	7.08	0.38	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5115	5115	T	G	MI.14126	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	646	216	F	V	Ttc/Gtc	-1.12	0	0	possibly_damaging	0.77	neutral	0.27	neutral	2.64	deleterious	-7.46	deleterious	-6.51	medium_impact	2.1	0.78	neutral	0.13	damaging	4.17	23.80	deleterious	0.13	0.4	0.43	neutral	0.81	disease	0.75	disease	0.69	disease	4	0.83	neutral	0.25	neutral	0	NA	0.72	deleterious	-1.28	low_impact	-0.03	medium_impact	0.62	medium_impact	0.25	0.8	0.29	7.08	0.29	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5116	5116	T	C	MI.14127	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	647	216	F	S	tTc/tCc	4.63	1	0	probably_damaging	0.96	neutral	0.22	neutral	2.63	deleterious	-9	deleterious	-7.52	medium_impact	2.52	0.9	neutral	0.17	damaging	4.32	24.00	deleterious	0.07	0.35	0.56	disease	0.83	disease	0.73	disease	0.7	disease	4	0.97	neutral	0.13	neutral	1	deleterious	0.80	deleterious	-2.06	low_impact	-0.1	medium_impact	0.98	medium_impact	0.28	0.8	0.29	7.08	0.52	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5116	5116	T	A	MI.14128	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	647	216	F	Y	tTc/tAc	4.63	1	0	probably_damaging	0.93	neutral	0.53	neutral	2.69	deleterious	-5.93	deleterious	-2.83	medium_impact	2.73	0.84	neutral	0.11	damaging	4.46	24.20	deleterious	0.2	0.45	0.37	neutral	0.74	disease	0.71	disease	0.68	disease	4	0.92	neutral	0.3	neutral	1	deleterious	0.75	deleterious	-1.83	low_impact	0.24	medium_impact	1.15	medium_impact	0.37	0.8	0.29	7.08	0.48	N	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5116	5116	T	G	MI.14129	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	647	216	F	C	tTc/tGc	4.63	1	0	probably_damaging	0.99	neutral	0.08	neutral	2.62	deleterious	-10.27	deleterious	-7.5	medium_impact	2.38	0.83	neutral	0.13	damaging	4.14	23.80	deleterious	0.08	0.35	0.79	disease	0.83	disease	0.75	disease	0.68	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.81	deleterious	-2.62	low_impact	-0.38	medium_impact	0.86	medium_impact	0.15	0.8	0.29	7.08	0.44	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9191	9191	T	C	MI.1413	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	665	222	L	P	cTg/cCg	-2.65	0	0	probably_damaging	1	deleterious	0.01	neutral	3.99	deleterious	-6.08	deleterious	-6.17	high_impact	4.1	0.27	damaging	0.15	damaging	4.23	23.90	deleterious	0.22	0.65	NA	NA	0.56	disease	0.71	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-0.84	medium_impact	2.42	high_impact	0.41	0.9	51.33	8.07	0.75	P	1.00	disease_causing_automatic	1	0.28	rs386829069	Pathogenic	Leigh_syndrome	48652	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	.	.	T9191C	Leigh Disease	-	+	Reported	1	P	P	P	damaging
chrM	5117	5117	C	A	MI.14130	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	648	216	F	L	ttC/ttA	7.4	1	0	benign	0.09	neutral	0.59	neutral	2.74	deleterious	-5.12	deleterious	-5.52	medium_impact	2.1	0.92	neutral	0.22	damaging	4.71	24.60	deleterious	0.15	0.4	0.12	neutral	0.8	disease	0.68	disease	0.55	disease	1	0.32	neutral	0.75	deleterious	-3	neutral	0.27	neutral	0.12	medium_impact	0.3	medium_impact	0.62	medium_impact	0.36	0.8	0.29	7.08	0.51	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5117	5117	C	G	MI.14131	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	648	216	F	L	ttC/ttG	7.4	1	0	benign	0.09	neutral	0.59	neutral	2.74	deleterious	-5.12	deleterious	-5.52	medium_impact	2.1	0.92	neutral	0.22	damaging	4.39	24.10	deleterious	0.15	0.4	0.12	neutral	0.8	disease	0.68	disease	0.55	disease	1	0.32	neutral	0.75	deleterious	-3	neutral	0.27	neutral	0.12	medium_impact	0.3	medium_impact	0.62	medium_impact	0.36	0.8	0.29	7.08	0.51	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5118	5118	C	G	MI.14132	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	649	217	L	V	Cta/Gta	-2.5	0	0	possibly_damaging	0.79	neutral	0.58	neutral	4.42	neutral	-1.98	neutral	-0.92	low_impact	1.74	0.93	neutral	0.7	neutral	3.39	23.00	deleterious	0.33	0.5	0.28	neutral	0.38	neutral	0.57	disease	0.46	neutral	1	0.76	neutral	0.4	neutral	-3	neutral	0.57	deleterious	-1.32	low_impact	0.29	medium_impact	0.32	medium_impact	0.62	0.8	3.46	7.39	0.33	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5118	5118	C	A	MI.14133	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	649	217	L	M	Cta/Ata	-2.5	0	0	possibly_damaging	0.46	neutral	0.36	neutral	4.38	neutral	-1.98	neutral	1.78	neutral_impact	0.26	0.85	neutral	0.86	neutral	1.04	10.87	neutral	0.25	0.45	0.19	neutral	0.09	neutral	0.26	neutral	0.26	neutral	5	0.6	neutral	0.45	neutral	-3	neutral	0.36	neutral	-0.73	medium_impact	0.07	medium_impact	-0.93	medium_impact	0.39	0.8	3.46	7.39	0.42	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5119	5119	T	G	MI.14134	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	650	217	L	R	cTa/cGa	-2.96	0	0	probably_damaging	0.98	neutral	0.31	neutral	4.29	deleterious	-5.01	deleterious	-2.77	medium_impact	2.71	0.81	neutral	0.44	neutral	4.23	23.90	deleterious	0.02	0.35	0.64	disease	0.82	disease	0.7	disease	0.68	disease	4	0.98	neutral	0.17	neutral	1	deleterious	0.83	deleterious	-2.34	low_impact	0.02	medium_impact	1.14	medium_impact	0.15	0.8	3.46	7.39	0.27	N	0.62	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5119	5119	T	C	MI.14135	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	650	217	L	P	cTa/cCa	-2.96	0	0	probably_damaging	0.99	neutral	0.18	neutral	4.29	deleterious	-5.36	deleterious	-3.57	medium_impact	2.5	0.76	neutral	0.4	neutral	3.93	23.50	deleterious	0.02	0.35	0.72	disease	0.81	disease	0.71	disease	0.69	disease	4	0.99	deleterious	0.1	neutral	1	deleterious	0.85	deleterious	-2.62	low_impact	-0.16	medium_impact	0.96	medium_impact	0.24	0.8	3.46	7.39	0.29	N	0.86	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5119	5119	T	A	MI.14136	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	650	217	L	Q	cTa/cAa	-2.96	0	0	probably_damaging	0.98	neutral	0.29	neutral	4.29	deleterious	-5.15	neutral	-2.06	medium_impact	2.16	0.83	neutral	0.51	neutral	4.10	23.70	deleterious	0.03	0.35	0.66	disease	0.72	disease	0.57	disease	0.63	disease	3	0.98	neutral	0.16	neutral	1	deleterious	0.77	deleterious	-2.34	low_impact	-0.01	medium_impact	0.67	medium_impact	0.23	0.8	3.46	7.39	0.3	N	0.56	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5121	5121	C	G	MI.14137	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	652	218	L	V	Cta/Gta	-7.34	0	0	benign	0.02	neutral	0.54	neutral	4.45	neutral	-0.26	neutral	-1.89	low_impact	1.3	0.92	neutral	0.89	neutral	0.37	6.38	deleterious	0.32	0.5	NA	NA	0.17	neutral	0.25	neutral	0.2	neutral	6	0.43	neutral	0.76	deleterious	-6	neutral	0.12	neutral	0.75	medium_impact	0.25	medium_impact	-0.05	medium_impact	0.57	0.8	7.2	8.74	0.4	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5121	5121	C	A	MI.14138	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	652	218	L	M	Cta/Ata	-7.34	0	0	benign	0.02	neutral	0.34	neutral	4.34	neutral	-2.29	neutral	-1.06	neutral_impact	0.62	0.86	neutral	0.94	neutral	1.90	15.57	deleterious	0.26	0.45	NA	NA	0.08	neutral	0.23	neutral	0.19	neutral	6	0.64	neutral	0.66	deleterious	-6	neutral	0.11	neutral	0.75	medium_impact	0.05	medium_impact	-0.62	medium_impact	0.41	0.8	7.2	8.74	0.51	N	0.05	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5122	5122	T	G	MI.14139	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	653	218	L	R	cTa/cGa	-3.42	0	0	benign	0.23	neutral	0.36	neutral	4.32	deleterious	-4.42	deleterious	-4.78	medium_impact	2.44	0.89	neutral	0.42	neutral	3.81	23.40	deleterious	0.02	0.35	NA	NA	0.67	disease	0.57	disease	0.65	disease	3	0.57	neutral	0.57	deleterious	-3	neutral	0.54	deleterious	-0.32	medium_impact	0.07	medium_impact	0.91	medium_impact	0.28	0.8	7.2	8.74	0.38	N	0.42	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9191	9191	T	G	MI.1414	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	665	222	L	R	cTg/cGg	-2.65	0	0	probably_damaging	1	deleterious	0.02	neutral	4	deleterious	-5.36	deleterious	-5.28	high_impact	3.75	0.37	damaging	0.13	damaging	4.53	24.30	deleterious	0.24	0.65	NA	NA	0.66	disease	0.7	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-0.66	medium_impact	2.12	high_impact	0.52	0.9	51.33	8.07	0.44	N	0.99	polymorphism	0.84	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5122	5122	T	C	MI.14140	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	653	218	L	P	cTa/cCa	-3.42	0	0	benign	0.23	neutral	0.21	neutral	4.31	deleterious	-4.95	deleterious	-5.52	low_impact	1.75	0.77	neutral	0.3	neutral	3.58	23.20	deleterious	0.02	0.35	NA	NA	0.73	disease	0.59	disease	0.65	disease	3	0.75	neutral	0.49	deleterious	-6	neutral	0.55	deleterious	-0.32	medium_impact	-0.11	medium_impact	0.33	medium_impact	0.33	0.8	7.2	8.74	0.29	N	0.72	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5122	5122	T	A	MI.14141	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	653	218	L	Q	cTa/cAa	-3.42	0	0	benign	0.41	neutral	0.32	neutral	4.37	deleterious	-3.99	deleterious	-4.62	medium_impact	2.79	0.87	neutral	0.47	neutral	3.95	23.60	deleterious	0.04	0.35	NA	NA	0.5	disease	0.43	neutral	0.44	neutral	1	0.63	neutral	0.46	neutral	-3	neutral	0.50	deleterious	-0.65	medium_impact	0.03	medium_impact	1.2	medium_impact	0.28	0.8	7.2	8.74	0.42	N	0.42	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5124	5124	C	G	MI.14142	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	655	219	L	V	Ctc/Gtc	-7.8	0	0	possibly_damaging	0.82	neutral	0.54	neutral	4.67	neutral	-0.19	neutral	-2.11	medium_impact	3.02	0.92	neutral	0.64	neutral	3.46	23.00	deleterious	0.31	0.45	0.21	neutral	0.35	neutral	0.63	disease	0.45	neutral	1	0.8	neutral	0.36	neutral	0	NA	0.63	deleterious	-1.4	low_impact	0.25	medium_impact	1.4	medium_impact	0.54	0.8	NA	NA	0.36	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5124	5124	C	A	MI.14143	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	655	219	L	I	Ctc/Atc	-7.8	0	0	possibly_damaging	0.77	neutral	0.49	neutral	4.55	neutral	-0.77	neutral	-1.16	low_impact	1.64	0.91	neutral	0.8	neutral	3.04	22.40	deleterious	0.3	0.45	0.36	neutral	0.35	neutral	0.35	neutral	0.44	neutral	1	0.75	neutral	0.36	neutral	-3	neutral	0.65	deleterious	-1.28	low_impact	0.2	medium_impact	0.24	medium_impact	0.48	0.8	NA	NA	0.38	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5124	5124	C	T	MI.14144	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	655	219	L	F	Ctc/Ttc	-7.8	0	0	benign	0.09	neutral	0.89	neutral	4.48	neutral	-2.1	neutral	-0.7	neutral_impact	0.04	0.9	neutral	0.92	neutral	2.04	16.48	deleterious	0.22	0.45	0.38	neutral	0.19	neutral	0.35	neutral	0.32	neutral	4	0.04	neutral	0.9	deleterious	-6	neutral	0.25	neutral	0.12	medium_impact	0.71	medium_impact	-1.11	low_impact	0.36	0.8	NA	NA	0.31	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5125	5125	T	C	MI.14145	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	656	219	L	P	cTc/cCc	-0.89	0	0	probably_damaging	0.99	neutral	0.21	neutral	4.41	deleterious	-4.84	deleterious	-5.68	medium_impact	3.36	0.75	neutral	0.36	neutral	4.00	23.60	deleterious	0.01	0.35	0.38	neutral	0.78	disease	0.76	disease	0.69	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-2.62	low_impact	-0.11	medium_impact	1.68	medium_impact	0.23	0.8	NA	NA	0.4	N	0.94	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5125	5125	T	A	MI.14146	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	656	219	L	H	cTc/cAc	-0.89	0	0	probably_damaging	0.99	neutral	0.55	neutral	4.42	deleterious	-3.59	deleterious	-4.7	medium_impact	3.02	0.9	neutral	0.6	neutral	4.29	24.00	deleterious	0.04	0.35	0.73	disease	0.72	disease	0.71	disease	0.69	disease	4	0.99	deleterious	0.28	neutral	1	deleterious	0.80	deleterious	-2.62	low_impact	0.26	medium_impact	1.4	medium_impact	0.28	0.8	NA	NA	0.32	N	0.82	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5125	5125	T	G	MI.14147	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	656	219	L	R	cTc/cGc	-0.89	0	0	probably_damaging	0.98	neutral	0.34	neutral	4.42	deleterious	-4.07	deleterious	-4.76	medium_impact	3.02	0.81	neutral	0.41	neutral	4.22	23.90	deleterious	0.01	0.35	0.64	disease	0.8	disease	0.76	disease	0.7	disease	4	0.98	deleterious	0.18	neutral	1	deleterious	0.82	deleterious	-2.34	low_impact	0.05	medium_impact	1.4	medium_impact	0.21	0.8	NA	NA	0.34	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5127	5127	A	T	MI.14148	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	658	220	N	Y	Aac/Tac	-6.65	0	0.01	benign	0.02	neutral	1	neutral	4.53	neutral	-2.94	neutral	-0.42	low_impact	1.46	0.92	neutral	0.81	neutral	1.00	10.66	neutral	0.14	0.4	0.67	disease	0.51	disease	0.36	neutral	0.5	disease	0	0.02	neutral	0.99	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	1.87	high_impact	0.09	medium_impact	0.21	0.8	15.27	9.25	0.21	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5127	5127	A	G	MI.14149	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	658	220	N	D	Aac/Gac	-6.65	0	0.01	benign	0.02	neutral	0.21	neutral	4.59	neutral	-0.81	neutral	-1.59	low_impact	1.83	0.87	neutral	0.74	neutral	0.61	8.23	deleterious	0.46	0.55	0.54	disease	0.45	neutral	0.56	disease	0.61	disease	2	0.78	neutral	0.6	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	-0.11	medium_impact	0.4	medium_impact	0.25	0.8	15.27	9.25	0.39	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9193	9193	C	A	MI.1415	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	667	223	H	N	Cac/Aac	1.29	1	0	probably_damaging	0.98	neutral	0.59	neutral	4.5	neutral	2.01	deleterious	-3.65	neutral_impact	-0.67	0.88	neutral	0.47	neutral	4.19	23.80	deleterious	0.83	0.85	NA	NA	0.37	neutral	0.48	neutral	0.15	neutral	7	0.98	neutral	0.31	neutral	-2	neutral	0.74	deleterious	-2.36	low_impact	0.38	medium_impact	-1.67	low_impact	0.55	0.9	NA	NA	0.35	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5127	5127	A	C	MI.14150	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	658	220	N	H	Aac/Cac	-6.65	0	0.01	possibly_damaging	0.81	neutral	0.54	neutral	4.54	neutral	-2.23	neutral	-0.65	low_impact	1.56	0.9	neutral	0.88	neutral	1.15	11.50	neutral	0.32	0.5	0.72	disease	0.48	neutral	0.46	neutral	0.6	disease	2	0.78	neutral	0.37	neutral	-3	neutral	0.65	deleterious	-1.37	low_impact	0.25	medium_impact	0.17	medium_impact	0.23	0.8	15.27	9.25	0.36	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5128	5128	A	C	MI.14151	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	659	220	N	T	aAc/aCc	0.95	0	0	possibly_damaging	0.52	neutral	0.43	neutral	4.59	neutral	-0.74	neutral	-0.48	low_impact	1.12	0.9	neutral	0.94	neutral	1.34	12.47	neutral	0.29	0.45	0.52	disease	0.32	neutral	0.45	neutral	0.36	neutral	3	0.57	neutral	0.46	neutral	-3	neutral	0.51	deleterious	-0.83	medium_impact	0.14	medium_impact	-0.2	medium_impact	0.27	0.8	15.27	9.25	0.48	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5128	5128	A	G	MI.14152	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	659	220	N	S	aAc/aGc	0.95	0	0	benign	0.26	neutral	0.47	neutral	4.63	neutral	-0.18	neutral	-0.36	low_impact	1.17	0.9	neutral	0.85	neutral	-0.26	0.83	neutral	0.48	0.55	0.42	neutral	0.37	neutral	0.44	neutral	0.46	neutral	1	0.43	neutral	0.61	deleterious	-6	neutral	0.44	deleterious	-0.38	medium_impact	0.18	medium_impact	-0.16	medium_impact	0.28	0.8	15.27	9.25	0.41	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5128	5128	A	T	MI.14153	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	659	220	N	I	aAc/aTc	0.95	0	0	possibly_damaging	0.75	neutral	0.48	neutral	4.58	neutral	-0.96	neutral	0.35	neutral_impact	0.62	0.87	neutral	0.96	neutral	1.99	16.15	deleterious	0.16	0.45	0.62	disease	0.31	neutral	0.34	neutral	0.61	disease	2	0.73	neutral	0.37	neutral	-3	neutral	0.60	deleterious	-1.23	low_impact	0.19	medium_impact	-0.62	medium_impact	0.20	0.8	15.27	9.25	0.42	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5129	5129	C	G	MI.14154	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	660	220	N	K	aaC/aaG	-0.89	0	0	possibly_damaging	0.44	neutral	0.39	neutral	4.64	neutral	-0.09	neutral	-1.14	neutral_impact	0.6	0.87	neutral	0.75	neutral	0.81	9.51	deleterious	0.4	0.5	0.4	neutral	0.31	neutral	0.46	neutral	0.46	neutral	1	0.56	neutral	0.48	deleterious	-3	neutral	0.50	deleterious	-0.7	medium_impact	0.1	medium_impact	-0.64	medium_impact	0.35	0.8	15.27	9.25	0.38	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5129	5129	C	A	MI.14155	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	660	220	N	K	aaC/aaA	-0.89	0	0	possibly_damaging	0.44	neutral	0.39	neutral	4.64	neutral	-0.09	neutral	-1.14	neutral_impact	0.6	0.87	neutral	0.75	neutral	1.24	11.95	neutral	0.4	0.5	0.4	neutral	0.31	neutral	0.46	neutral	0.46	neutral	1	0.56	neutral	0.48	deleterious	-3	neutral	0.50	deleterious	-0.7	medium_impact	0.1	medium_impact	-0.64	medium_impact	0.35	0.8	15.27	9.25	0.39	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5130	5130	T	G	MI.14156	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	661	221	L	V	Tta/Gta	-5.96	0	0	possibly_damaging	0.66	neutral	0.51	neutral	4.53	neutral	-1.27	neutral	-0.53	low_impact	1.08	0.92	neutral	0.85	neutral	0.35	6.16	deleterious	0.4	0.5	0.66	disease	0.1	neutral	0.37	neutral	0.38	neutral	2	0.63	neutral	0.43	neutral	-3	neutral	0.55	deleterious	-1.06	low_impact	0.22	medium_impact	-0.24	medium_impact	0.48	0.8	20.46	10.41	0.42	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5130	5130	T	A	MI.14157	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	661	221	L	M	Tta/Ata	-5.96	0	0	benign	0.3	neutral	0.34	neutral	4.45	neutral	-2.16	neutral	0.27	neutral_impact	0.55	0.91	neutral	0.94	neutral	0.28	5.50	deleterious	0.32	0.5	0.78	disease	0.08	neutral	0.26	neutral	0.37	neutral	3	0.59	neutral	0.52	deleterious	-6	neutral	0.42	neutral	-0.46	medium_impact	0.05	medium_impact	-0.68	medium_impact	0.56	0.8	20.46	10.41	0.55	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5131	5131	T	G	MI.14158	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	662	221	L	W	tTa/tGa	-5.73	0	0	probably_damaging	0.98	neutral	0.17	neutral	4.38	deleterious	-5.58	neutral	-1.24	low_impact	1.43	0.87	neutral	0.44	neutral	2.60	20.20	deleterious	0.07	0.35	0.94	disease	0.36	neutral	0.37	neutral	0.57	disease	1	0.99	deleterious	0.1	neutral	-2	neutral	0.74	deleterious	-2.34	low_impact	-0.17	medium_impact	0.06	medium_impact	0.21	0.8	20.46	10.41	0.43	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5131	5131	T	C	MI.14159	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	662	221	L	S	tTa/tCa	-5.73	0	0	benign	0.3	neutral	0.57	neutral	4.57	deleterious	-3.35	neutral	-1.2	neutral_impact	0.17	0.73	neutral	0.9	neutral	2.17	17.33	deleterious	0.07	0.35	0.62	disease	0.14	neutral	0.31	neutral	0.34	neutral	3	0.33	neutral	0.64	deleterious	-6	neutral	0.38	neutral	-0.46	medium_impact	0.28	medium_impact	-1	low_impact	0.29	0.8	20.46	10.41	0.31	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9193	9193	C	G	MI.1416	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	667	223	H	D	Cac/Gac	1.29	1	0	probably_damaging	0.99	neutral	0.33	neutral	4.41	neutral	0.69	deleterious	-4.85	neutral_impact	-0.82	0.79	neutral	0.39	neutral	4.18	23.80	deleterious	0.45	0.65	NA	NA	0.4	neutral	0.55	disease	0.32	neutral	4	0.99	deleterious	0.17	neutral	-2	neutral	0.77	deleterious	-2.65	low_impact	0.12	medium_impact	-1.8	low_impact	0.48	0.9	NA	NA	0.3	N	0.95	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5132	5132	A	T	MI.14160	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	663	221	L	F	ttA/ttT	-4.58	0	0	probably_damaging	0.91	neutral	0.78	neutral	4.44	neutral	-2.86	neutral	0.23	neutral_impact	-0.04	0.84	neutral	0.95	neutral	1.24	11.94	neutral	0.27	0.45	0.82	disease	0.16	neutral	0.26	neutral	0.37	neutral	3	0.9	neutral	0.44	neutral	-2	neutral	0.67	deleterious	-1.72	low_impact	0.51	medium_impact	-1.18	low_impact	0.50	0.8	20.46	10.41	0.32	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5132	5132	A	C	MI.14161	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	663	221	L	F	ttA/ttC	-4.58	0	0	probably_damaging	0.91	neutral	0.78	neutral	4.44	neutral	-2.86	neutral	0.23	neutral_impact	-0.04	0.84	neutral	0.95	neutral	1.07	11.06	neutral	0.27	0.45	0.82	disease	0.16	neutral	0.26	neutral	0.37	neutral	3	0.9	neutral	0.44	neutral	-2	neutral	0.67	deleterious	-1.72	low_impact	0.51	medium_impact	-1.18	low_impact	0.50	0.8	20.46	10.41	0.31	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5133	5133	A	G	MI.14162	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	664	222	N	D	Aac/Gac	-12.86	0	0	benign	0.32	neutral	0.21	neutral	4.62	neutral	-1.58	deleterious	-3.17	medium_impact	2.04	0.91	neutral	0.45	neutral	1.97	16.01	deleterious	0.5	0.6	0.66	disease	0.31	neutral	0.45	neutral	0.6	disease	2	0.75	neutral	0.45	neutral	-3	neutral	0.38	neutral	-0.5	medium_impact	-0.11	medium_impact	0.57	medium_impact	0.23	0.8	4.61	7.9	0.42	N	0.64	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5133	5133	A	T	MI.14163	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	664	222	N	Y	Aac/Tac	-12.86	0	0	possibly_damaging	0.87	neutral	1	neutral	4.64	neutral	-0.17	deleterious	-4.54	low_impact	0.88	0.94	neutral	0.77	neutral	2.13	17.07	deleterious	0.15	0.4	0.8	disease	0.34	neutral	0.29	neutral	0.64	disease	3	0.87	neutral	0.57	deleterious	-3	neutral	0.67	deleterious	-1.55	low_impact	1.87	high_impact	-0.4	medium_impact	0.21	0.8	4.61	7.9	0.27	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5133	5133	A	C	MI.14164	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	664	222	N	H	Aac/Cac	-12.86	0	0	possibly_damaging	0.87	neutral	0.54	neutral	4.62	neutral	-1.1	deleterious	-2.61	low_impact	1.5	0.89	neutral	0.91	neutral	1.54	13.51	neutral	0.35	0.5	0.59	disease	0.32	neutral	0.32	neutral	0.61	disease	2	0.86	neutral	0.34	neutral	-3	neutral	0.64	deleterious	-1.55	low_impact	0.25	medium_impact	0.12	medium_impact	0.19	0.8	4.61	7.9	0.33	N	0.40	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5134	5134	A	C	MI.14165	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	665	222	N	T	aAc/aCc	-0.89	0	0	benign	0.32	neutral	0.42	neutral	4.67	neutral	0.74	deleterious	-3.12	neutral_impact	-0.26	0.84	neutral	0.99	neutral	0.00	2.62	deleterious	0.31	0.45	0.45	neutral	0.07	neutral	0.26	neutral	0.25	neutral	5	0.5	neutral	0.55	deleterious	-6	neutral	0.32	neutral	-0.5	medium_impact	0.13	medium_impact	-1.36	low_impact	0.26	0.8	4.61	7.9	0.41	N	0.46	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5134	5134	A	T	MI.14166	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	665	222	N	I	aAc/aTc	-0.89	0	0	possibly_damaging	0.77	neutral	0.42	neutral	4.88	neutral	2.99	deleterious	-5.65	low_impact	0.86	0.83	neutral	0.76	neutral	2.29	18.11	deleterious	0.16	0.45	0.7	disease	0.24	neutral	0.3	neutral	0.56	disease	1	0.77	neutral	0.33	neutral	-3	neutral	0.60	deleterious	-1.28	low_impact	0.13	medium_impact	-0.42	medium_impact	0.09	0.8	4.61	7.9	0.36	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5134	5134	A	G	MI.14167	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	665	222	N	S	aAc/aGc	-0.89	0	0	benign	0.01	neutral	0.45	neutral	4.69	neutral	1.13	neutral	-2.34	neutral_impact	0.3	0.93	neutral	0.99	neutral	-0.66	0.09	neutral	0.45	0.55	0.4	neutral	0.12	neutral	0.29	neutral	0.3	neutral	4	0.53	neutral	0.72	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.16	medium_impact	-0.89	medium_impact	0.23	0.8	4.61	7.9	0.44	N	0.09	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5135	5135	C	G	MI.14168	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	666	222	N	K	aaC/aaG	-0.66	0	0	possibly_damaging	0.44	neutral	0.3	neutral	4.63	neutral	-0.43	deleterious	-3.63	low_impact	1.07	0.89	neutral	0.48	neutral	1.11	11.30	neutral	0.44	0.55	0.54	disease	0.35	neutral	0.45	neutral	0.44	neutral	1	0.66	neutral	0.43	neutral	-3	neutral	0.41	neutral	-0.7	medium_impact	0	medium_impact	-0.24	medium_impact	0.26	0.8	4.61	7.9	0.44	N	0.72	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5135	5135	C	A	MI.14169	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	666	222	N	K	aaC/aaA	-0.66	0	0	possibly_damaging	0.44	neutral	0.3	neutral	4.63	neutral	-0.43	deleterious	-3.63	low_impact	1.07	0.89	neutral	0.48	neutral	1.52	13.41	neutral	0.44	0.55	0.54	disease	0.35	neutral	0.45	neutral	0.44	neutral	1	0.66	neutral	0.43	neutral	-3	neutral	0.41	neutral	-0.7	medium_impact	0	medium_impact	-0.24	medium_impact	0.26	0.8	4.61	7.9	0.44	N	0.72	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9193	9193	C	T	MI.1417	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	667	223	H	Y	Cac/Tac	1.29	1	0	probably_damaging	0.98	deleterious	0.01	neutral	4.37	neutral	-1.3	deleterious	-3.42	low_impact	1.15	0.94	neutral	0.55	neutral	3.95	23.60	deleterious	0.63	0.7	NA	NA	0.34	neutral	0.52	disease	0.3	neutral	4	1	deleterious	0.02	neutral	2	deleterious	0.77	deleterious	-2.36	low_impact	-0.84	medium_impact	-0.11	medium_impact	0.40	0.9	NA	NA	0.43	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5136	5136	T	C	MI.14170	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	667	223	S	P	Tcc/Ccc	-5.27	0	0	probably_damaging	1	neutral	0.28	neutral	4.57	neutral	-2.49	deleterious	-4.04	medium_impact	2.38	0.91	neutral	0.17	damaging	4.08	23.70	deleterious	0.11	0.4	0.78	disease	0.84	disease	0.53	disease	0.75	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.02	medium_impact	0.86	medium_impact	0.11	0.8	2.88	7.74	0.36	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5136	5136	T	A	MI.14171	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	667	223	S	T	Tcc/Acc	-5.27	0	0	probably_damaging	1	neutral	0.57	neutral	4.61	neutral	-0.6	neutral	-1.86	low_impact	1.27	0.86	neutral	0.92	neutral	2.89	21.80	deleterious	0.45	0.55	0.59	disease	0.27	neutral	0.26	neutral	0.57	disease	1	1	deleterious	0.29	neutral	-2	neutral	0.67	deleterious	-3.54	low_impact	0.28	medium_impact	-0.08	medium_impact	0.30	0.8	2.88	7.74	0.33	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5136	5136	T	G	MI.14172	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	667	223	S	A	Tcc/Gcc	-5.27	0	0	probably_damaging	1	neutral	0.71	neutral	4.63	neutral	-0.25	neutral	-2.35	low_impact	1.82	0.89	neutral	0.91	neutral	2.74	21.00	deleterious	0.38	0.5	0.58	disease	0.28	neutral	0.42	neutral	0.56	disease	1	0.99	deleterious	0.36	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.42	medium_impact	0.39	medium_impact	0.17	0.8	2.88	7.74	0.32	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5137	5137	C	A	MI.14173	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	668	223	S	Y	tCc/tAc	-0.89	0	0	probably_damaging	1	neutral	1	neutral	4.78	neutral	1.41	deleterious	-4.82	medium_impact	2.83	0.91	neutral	0.66	neutral	4.12	23.80	deleterious	0.18	0.45	0.76	disease	0.63	disease	0.51	disease	0.56	disease	1	1	deleterious	0.5	deleterious	1	deleterious	0.75	deleterious	-3.54	low_impact	1.87	high_impact	1.24	medium_impact	0.11	0.8	2.88	7.74	0.29	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5137	5137	C	T	MI.14174	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	668	223	S	F	tCc/tTc	-0.89	0	0	probably_damaging	1	neutral	0.74	neutral	4.62	neutral	-0.48	deleterious	-4.9	medium_impact	2.83	0.89	neutral	0.22	damaging	4.32	24.00	deleterious	0.21	0.45	0.82	disease	0.71	disease	0.59	disease	0.72	disease	4	1	deleterious	0.37	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.46	medium_impact	1.24	medium_impact	0.06	0.8	2.88	7.74	0.27	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5137	5137	C	G	MI.14175	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	668	223	S	C	tCc/tGc	-0.89	0	0	probably_damaging	1	neutral	0.19	neutral	4.59	neutral	-1.13	deleterious	-3.85	medium_impact	3.17	0.86	neutral	0.13	damaging	3.65	23.20	deleterious	0.19	0.45	0.91	disease	0.68	disease	0.54	disease	0.72	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.14	medium_impact	1.52	medium_impact	0.12	0.8	2.88	7.74	0.33	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5139	5139	A	G	MI.14176	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	670	224	S	G	Agc/Ggc	-11.25	0	0	benign	0.34	neutral	0.49	neutral	4.47	neutral	-2.76	deleterious	-2.7	medium_impact	2	0.87	neutral	0.49	neutral	3.64	23.20	deleterious	0.29	0.45	0.76	disease	0.47	neutral	0.59	disease	0.67	disease	3	0.43	neutral	0.58	deleterious	-3	neutral	0.44	deleterious	-0.53	medium_impact	0.2	medium_impact	0.54	medium_impact	0.28	0.8	4.32	8.06	0.3	N	0.33	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5139	5139	A	T	MI.14177	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	670	224	S	C	Agc/Tgc	-11.25	0	0	probably_damaging	0.95	neutral	0.27	neutral	4.44	deleterious	-4.64	deleterious	-3.54	medium_impact	2.35	0.8	neutral	0.39	neutral	3.53	23.10	deleterious	0.13	0.4	0.87	disease	0.69	disease	0.59	disease	0.69	disease	4	0.96	neutral	0.16	neutral	1	deleterious	0.73	deleterious	-1.97	low_impact	-0.03	medium_impact	0.83	medium_impact	0.15	0.8	4.32	8.06	0.29	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5139	5139	A	C	MI.14178	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	670	224	S	R	Agc/Cgc	-11.25	0	0	possibly_damaging	0.62	neutral	0.36	neutral	4.49	neutral	-1.99	deleterious	-2.82	medium_impact	2.69	0.86	neutral	0.4	neutral	3.90	23.50	deleterious	0.12	0.4	0.79	disease	0.75	disease	0.66	disease	0.71	disease	4	0.68	neutral	0.37	neutral	0	NA	0.63	deleterious	-0.99	medium_impact	0.07	medium_impact	1.12	medium_impact	0.34	0.8	4.32	8.06	0.28	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5140	5140	G	A	MI.14179	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	671	224	S	N	aGc/aAc	-2.04	0	0	benign	0.01	neutral	0.84	neutral	4.5	neutral	-1.75	neutral	-0.78	low_impact	1.88	0.92	neutral	0.83	neutral	2.00	16.21	deleterious	0.52	0.6	0.8	disease	0.51	disease	0.38	neutral	0.38	neutral	2	0.12	neutral	0.92	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	0.61	medium_impact	0.44	medium_impact	0.34	0.8	4.32	8.06	0.24	N	0.23	polymorphism	1	0.01	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9194	9194	A	G	MI.1418	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	668	223	H	R	cAc/cGc	4.52	1	0	probably_damaging	0.99	neutral	0.13	neutral	4.42	neutral	0.86	deleterious	-3.91	neutral_impact	0.3	0.93	neutral	0.54	neutral	3.27	22.80	deleterious	0.73	0.8	NA	NA	0.45	neutral	0.43	neutral	0.22	neutral	6	0.99	deleterious	0.07	neutral	-2	neutral	0.78	deleterious	-2.65	low_impact	-0.18	medium_impact	-0.84	medium_impact	0.40	0.9	NA	NA	0.48	N	0.43	disease_causing	0.87	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5140	5140	G	T	MI.14180	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	671	224	S	I	aGc/aTc	-2.04	0	0	possibly_damaging	0.86	neutral	0.66	neutral	4.49	neutral	-2.08	deleterious	-3.99	neutral_impact	0.12	0.91	neutral	0.87	neutral	2.89	21.80	deleterious	0.15	0.45	0.53	disease	0.67	disease	0.4	neutral	0.25	neutral	5	0.83	neutral	0.4	neutral	-3	neutral	0.68	deleterious	-1.52	low_impact	0.37	medium_impact	-1.04	low_impact	0.22	0.8	4.32	8.06	0.27	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5140	5140	G	C	MI.14181	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	671	224	S	T	aGc/aCc	-2.04	0	0	benign	0.42	neutral	0.96	neutral	4.63	neutral	-0.09	neutral	-0.81	neutral_impact	-0.46	0.9	neutral	0.98	neutral	1.25	11.99	neutral	0.32	0.5	0.48	neutral	0.11	neutral	0.25	neutral	0.29	neutral	4	0.37	neutral	0.77	deleterious	-6	neutral	0.46	deleterious	-0.67	medium_impact	0.98	medium_impact	-1.53	low_impact	0.34	0.8	4.32	8.06	0.33	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5142	5142	A	G	MI.14182	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	673	225	T	A	Acc/Gcc	-14.47	0	0	benign	0.33	neutral	0.77	neutral	4.63	neutral	-0.27	deleterious	-4.44	medium_impact	2.52	0.89	neutral	0.6	neutral	1.86	15.37	deleterious	0.38	0.5	0.51	disease	0.46	neutral	0.56	disease	0.5	neutral	0	0.22	neutral	0.72	deleterious	-3	neutral	0.40	neutral	-0.52	medium_impact	0.5	medium_impact	0.98	medium_impact	0.13	0.8	0.29	6.79	0.3	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5142	5142	A	C	MI.14183	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	673	225	T	P	Acc/Ccc	-14.47	0	0	probably_damaging	0.92	neutral	0.3	neutral	4.57	neutral	-2.02	deleterious	-5.46	medium_impact	2.23	0.8	neutral	0.52	neutral	3.53	23.10	deleterious	0.08	0.35	0.89	disease	0.82	disease	0.7	disease	0.69	disease	4	0.93	neutral	0.19	neutral	1	deleterious	0.78	deleterious	-1.77	low_impact	0	medium_impact	0.73	medium_impact	0.33	0.8	0.29	6.79	0.28	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5142	5142	A	T	MI.14184	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	673	225	T	S	Acc/Tcc	-14.47	0	0	possibly_damaging	0.61	neutral	0.75	neutral	4.66	neutral	0.19	deleterious	-3.5	low_impact	1.45	0.85	neutral	0.75	neutral	1.80	14.98	neutral	0.46	0.55	0.64	disease	0.47	neutral	0.43	neutral	0.53	disease	1	0.52	neutral	0.57	deleterious	-3	neutral	0.59	deleterious	-0.98	medium_impact	0.47	medium_impact	0.08	medium_impact	0.33	0.8	0.29	6.79	0.25	N	0.40	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5143	5143	C	G	MI.14185	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	674	225	T	S	aCc/aGc	1.41	0	0	possibly_damaging	0.61	neutral	0.75	neutral	4.66	neutral	0.19	deleterious	-3.5	low_impact	1.45	0.85	neutral	0.75	neutral	1.94	15.82	deleterious	0.46	0.55	0.64	disease	0.47	neutral	0.43	neutral	0.53	disease	1	0.52	neutral	0.57	deleterious	-3	neutral	0.59	deleterious	-0.98	medium_impact	0.47	medium_impact	0.08	medium_impact	0.33	0.8	0.29	6.79	0.26	N	0.40	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5143	5143	C	T	MI.14186	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	674	225	T	I	aCc/aTc	1.41	0	0	benign	0.22	neutral	0.5	neutral	4.57	neutral	-2.15	deleterious	-5.3	medium_impact	2.36	0.84	neutral	0.57	neutral	2.23	17.74	deleterious	0.22	0.45	0.43	neutral	0.66	disease	0.51	disease	0.31	neutral	4	0.4	neutral	0.64	deleterious	-3	neutral	0.43	deleterious	-0.29	medium_impact	0.21	medium_impact	0.84	medium_impact	0.20	0.8	0.29	6.79	0.28	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5143	5143	C	A	MI.14187	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	674	225	T	N	aCc/aAc	1.41	0	0	possibly_damaging	0.9	neutral	0.56	neutral	4.65	neutral	0.16	deleterious	-4.52	low_impact	1.5	0.89	neutral	0.61	neutral	3.64	23.20	deleterious	0.41	0.5	0.87	disease	0.66	disease	0.5	neutral	0.5	neutral	0	0.88	neutral	0.33	neutral	-3	neutral	0.73	deleterious	-1.67	low_impact	0.27	medium_impact	0.12	medium_impact	0.34	0.8	0.29	6.79	0.32	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5145	5145	A	C	MI.14188	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	676	226	T	P	Acg/Ccg	-11.48	0	0	probably_damaging	1	neutral	0.2	neutral	4.53	neutral	-2.61	deleterious	-5.14	medium_impact	2.64	0.71	neutral	0.08	damaging	3.55	23.10	deleterious	0.07	0.35	0.92	disease	0.83	disease	0.75	disease	0.82	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.13	medium_impact	1.08	medium_impact	0.34	0.8	2.02	7.29	0.25	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5145	5145	A	T	MI.14189	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	676	226	T	S	Acg/Tcg	-11.48	0	0	probably_damaging	1	neutral	0.41	neutral	4.65	neutral	0.11	deleterious	-2.85	neutral_impact	0.4	0.88	neutral	0.9	neutral	1.98	16.08	deleterious	0.47	0.55	0.56	disease	0.39	neutral	0.3	neutral	0.61	disease	2	1	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.12	medium_impact	-0.81	medium_impact	0.44	0.8	2.02	7.29	0.36	N	0.65	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9194	9194	A	C	MI.1419	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	668	223	H	P	cAc/cCc	4.52	1	0	probably_damaging	0.99	neutral	0.07	neutral	4.37	neutral	-0.77	deleterious	-5.74	low_impact	1.5	0.74	neutral	0.31	neutral	3.60	23.20	deleterious	0.24	0.65	NA	NA	0.67	disease	0.65	disease	0.73	disease	5	1	deleterious	0.04	neutral	-2	neutral	0.82	deleterious	-2.65	low_impact	-0.34	medium_impact	0.19	medium_impact	0.48	0.9	NA	NA	0.4	N	0.99	disease_causing	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5145	5145	A	G	MI.14190	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	676	226	T	A	Acg/Gcg	-11.48	0	0	probably_damaging	1	neutral	0.51	neutral	4.59	neutral	-0.83	deleterious	-4.1	medium_impact	3.19	0.86	neutral	0.25	damaging	3.50	23.10	deleterious	0.34	0.5	0.58	disease	0.42	neutral	0.62	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.22	medium_impact	1.54	medium_impact	0.33	0.8	2.02	7.29	0.28	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5146	5146	C	A	MI.14191	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	677	226	T	K	aCg/aAg	1.87	0.01	0	probably_damaging	1	neutral	0.31	neutral	4.61	neutral	-0.47	deleterious	-4.97	neutral_impact	0.69	0.9	neutral	0.75	neutral	2.86	21.70	deleterious	0.12	0.4	0.8	disease	0.18	neutral	0.36	neutral	0.4	neutral	2	1	deleterious	0.16	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.02	medium_impact	-0.56	medium_impact	0.35	0.8	2.02	7.29	0.49	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5146	5146	C	T	MI.14192	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	677	226	T	M	aCg/aTg	1.87	0.01	0	probably_damaging	1	neutral	0.22	neutral	4.54	neutral	-2	deleterious	-5.14	medium_impact	2.38	0.84	neutral	0.11	damaging	4.14	23.80	deleterious	0.17	0.45	0.81	disease	0.58	disease	0.64	disease	0.7	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.1	medium_impact	0.86	medium_impact	0.41	0.8	2.02	7.29	0.3	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5148	5148	A	G	MI.14193	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	679	227	T	A	Acc/Gcc	-6.42	0	0	benign	0.06	neutral	0.64	neutral	4.61	neutral	-0.51	deleterious	-3.97	medium_impact	2.08	0.94	neutral	0.67	neutral	1.29	12.21	neutral	0.21	0.45	0.63	disease	0.26	neutral	0.54	disease	0.57	disease	1	0.29	neutral	0.79	deleterious	-3	neutral	0.18	neutral	0.3	medium_impact	0.35	medium_impact	0.61	medium_impact	0.22	0.8	2.02	8.1	0.3	N	0.42	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5148	5148	A	T	MI.14194	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	679	227	T	S	Acc/Tcc	-6.42	0	0	possibly_damaging	0.56	neutral	0.65	neutral	4.59	neutral	-1.21	deleterious	-3.23	low_impact	1.8	0.86	neutral	0.59	neutral	3.48	23.10	deleterious	0.28	0.45	0.51	disease	0.34	neutral	0.51	disease	0.39	neutral	2	0.48	neutral	0.55	deleterious	-3	neutral	0.60	deleterious	-0.89	medium_impact	0.36	medium_impact	0.37	medium_impact	0.47	0.8	2.02	8.1	0.25	N	0.37	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5148	5148	A	C	MI.14195	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	679	227	T	P	Acc/Ccc	-6.42	0	0	probably_damaging	0.93	neutral	0.25	neutral	4.56	neutral	-2.76	deleterious	-5.17	medium_impact	2.42	0.78	neutral	0.34	neutral	3.91	23.50	deleterious	0.05	0.35	0.83	disease	0.75	disease	0.66	disease	0.75	disease	5	0.95	neutral	0.16	neutral	1	deleterious	0.80	deleterious	-1.83	low_impact	-0.06	medium_impact	0.89	medium_impact	0.34	0.8	2.02	8.1	0.25	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5149	5149	C	A	MI.14196	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	680	227	T	N	aCc/aAc	3.02	0.04	0	probably_damaging	0.9	neutral	0.55	neutral	4.56	neutral	-2.4	deleterious	-4.36	medium_impact	2.08	0.85	neutral	0.64	neutral	3.56	23.10	deleterious	0.18	0.45	0.87	disease	0.51	disease	0.53	disease	0.63	disease	3	0.89	neutral	0.33	neutral	1	deleterious	0.75	deleterious	-1.67	low_impact	0.26	medium_impact	0.61	medium_impact	0.37	0.8	2.02	8.1	0.27	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5149	5149	C	G	MI.14197	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	680	227	T	S	aCc/aGc	3.02	0.04	0	possibly_damaging	0.56	neutral	0.65	neutral	4.59	neutral	-1.21	deleterious	-3.23	low_impact	1.8	0.86	neutral	0.59	neutral	3.13	22.60	deleterious	0.28	0.45	0.51	disease	0.34	neutral	0.51	disease	0.39	neutral	2	0.48	neutral	0.55	deleterious	-3	neutral	0.60	deleterious	-0.89	medium_impact	0.36	medium_impact	0.37	medium_impact	0.47	0.8	2.02	8.1	0.29	N	0.37	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5149	5149	C	T	MI.14198	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	680	227	T	I	aCc/aTc	3.02	0.04	0	benign	0.08	neutral	0.62	neutral	4.88	neutral	1.83	deleterious	-4.67	neutral_impact	-0.15	0.96	neutral	0.93	neutral	-0.06	2.01	deleterious	0.11	0.4	0.45	neutral	0.11	neutral	0.18	neutral	0.27	neutral	5	0.29	neutral	0.77	deleterious	-6	neutral	0.20	neutral	0.17	medium_impact	0.33	medium_impact	-1.27	low_impact	0.34	0.8	2.02	8.1	0.43	N	0.10	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5151	5151	C	G	MI.14199	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	682	228	L	V	Cta/Gta	-6.42	0	0	probably_damaging	1	neutral	0.5	neutral	4.62	neutral	-0.32	neutral	-2.48	low_impact	1.74	0.9	neutral	0.19	damaging	1.92	15.72	deleterious	0.39	0.5	0.75	disease	0.21	neutral	0.26	neutral	0.53	disease	1	1	deleterious	0.25	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.21	medium_impact	0.32	medium_impact	0.38	0.8	6.63	8.81	0.32	N	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8593	8593	A	T	MI.142	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	67	23	I	F	Atc/Ttc	-8.2	0	0	possibly_damaging	0.68	neutral	0.27	neutral	4.31	neutral	-1.25	deleterious	-2.51	low_impact	0.94	0.9	neutral	0.56	neutral	3.31	22.90	deleterious	0.39	0.65	0.48	neutral	0.63	disease	0.55	disease	0.65	disease	3	0.78	neutral	0.3	neutral	-3	neutral	0.63	deleterious	-1.07	low_impact	0.05	medium_impact	-0.29	medium_impact	0.58	0.9	19.03	10.37	0.37	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9194	9194	A	T	MI.1420	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	668	223	H	L	cAc/cTc	4.52	1	0	probably_damaging	0.99	neutral	0.08	neutral	4.39	neutral	-0.22	deleterious	-6.52	neutral_impact	0.34	0.85	neutral	0.42	neutral	4.20	23.90	deleterious	0.37	0.65	NA	NA	0.45	neutral	0.52	disease	0.37	neutral	3	1	deleterious	0.05	neutral	-2	neutral	0.75	deleterious	-2.65	low_impact	-0.31	medium_impact	-0.81	medium_impact	0.40	0.9	NA	NA	0.42	N	0.96	disease_causing	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5151	5151	C	A	MI.14200	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	682	228	L	M	Cta/Ata	-6.42	0	0	probably_damaging	1	neutral	0.23	neutral	4.57	neutral	-1.56	neutral	-1.64	low_impact	1.53	0.87	neutral	0.25	damaging	2.59	20.10	deleterious	0.31	0.45	0.84	disease	0.23	neutral	0.14	neutral	0.56	disease	1	1	deleterious	0.12	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	-0.08	medium_impact	0.14	medium_impact	0.48	0.8	6.63	8.81	0.45	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5152	5152	T	C	MI.14201	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	683	228	L	P	cTa/cCa	-1.35	0	0	probably_damaging	1	neutral	0.21	neutral	4.55	neutral	-2.47	deleterious	-5.89	low_impact	1.43	0.79	neutral	0.21	damaging	2.56	19.88	deleterious	0.06	0.35	0.96	disease	0.7	disease	0.46	neutral	0.78	disease	6	1	deleterious	0.11	neutral	-2	neutral	0.85	deleterious	-3.54	low_impact	-0.11	medium_impact	0.06	medium_impact	0.18	0.8	6.63	8.81	0.27	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5152	5152	T	A	MI.14202	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	683	228	L	Q	cTa/cAa	-1.35	0	0	probably_damaging	1	neutral	0.29	neutral	4.63	neutral	-0.19	deleterious	-4.99	neutral_impact	0.49	0.88	neutral	0.26	damaging	2.29	18.09	deleterious	0.17	0.45	0.95	disease	0.46	neutral	0.15	neutral	0.68	disease	4	1	deleterious	0.15	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	-0.01	medium_impact	-0.73	medium_impact	0.21	0.8	6.63	8.81	0.39	N	0.73	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5152	5152	T	G	MI.14203	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	683	228	L	R	cTa/cGa	-1.35	0	0	probably_damaging	1	neutral	0.34	neutral	4.72	neutral	0.79	deleterious	-5.02	low_impact	1.48	0.9	neutral	0.13	damaging	2.21	17.54	deleterious	0.12	0.4	0.95	disease	0.66	disease	0.34	neutral	0.79	disease	6	1	deleterious	0.17	neutral	-2	neutral	0.81	deleterious	-3.54	low_impact	0.05	medium_impact	0.1	medium_impact	0.20	0.8	6.63	8.81	0.35	N	0.68	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5154	5154	C	A	MI.14204	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	685	229	L	M	Cta/Ata	-6.19	0	0	benign	0.02	neutral	0.31	neutral	4.58	neutral	-1.91	neutral	0.87	neutral_impact	-1.13	0.96	neutral	0.88	neutral	0.84	9.68	deleterious	0.29	0.45	0.74	disease	0.11	neutral	0.15	neutral	0.45	neutral	1	0.68	neutral	0.65	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.02	medium_impact	-2.1	low_impact	0.42	0.8	1.73	7.38	0.53	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5154	5154	C	G	MI.14205	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	685	229	L	V	Cta/Gta	-6.19	0	0	benign	0.14	neutral	0.53	neutral	4.61	neutral	-0.88	neutral	-0.02	neutral_impact	0.11	0.89	neutral	0.72	neutral	1.87	15.38	deleterious	0.31	0.45	0.73	disease	0.12	neutral	0.43	neutral	0.4	neutral	2	0.37	neutral	0.7	deleterious	-6	neutral	0.31	neutral	-0.08	medium_impact	0.24	medium_impact	-1.05	low_impact	0.32	0.8	1.73	7.38	0.37	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5155	5155	T	G	MI.14206	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	686	229	L	R	cTa/cGa	-2.04	0	0	possibly_damaging	0.46	neutral	0.34	neutral	4.61	neutral	0.64	neutral	0.04	neutral_impact	0	0.84	neutral	0.47	neutral	4.14	23.80	deleterious	0.12	0.4	0.87	disease	0.54	disease	0.43	neutral	0.61	disease	2	0.62	neutral	0.44	neutral	-3	neutral	0.65	deleterious	-0.73	medium_impact	0.05	medium_impact	-1.14	low_impact	0.15	0.8	1.73	7.38	0.34	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5155	5155	T	C	MI.14207	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	686	229	L	P	cTa/cCa	-2.04	0	0	possibly_damaging	0.55	neutral	0.23	neutral	4.56	neutral	-2.37	neutral	-0.11	neutral_impact	0.26	0.78	neutral	0.74	neutral	3.92	23.50	deleterious	0.08	0.35	0.96	disease	0.67	disease	0.62	disease	0.84	disease	7	0.76	neutral	0.34	neutral	-3	neutral	0.78	deleterious	-0.88	medium_impact	-0.08	medium_impact	-0.93	medium_impact	0.19	0.8	1.73	7.38	0.36	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5155	5155	T	A	MI.14208	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	686	229	L	Q	cTa/cAa	-2.04	0	0	possibly_damaging	0.46	neutral	0.33	neutral	4.6	neutral	-0.13	neutral	0.76	neutral_impact	-1.7	0.9	neutral	0.66	neutral	4.21	23.90	deleterious	0.18	0.45	0.95	disease	0.42	neutral	0.33	neutral	0.67	disease	3	0.63	neutral	0.44	neutral	-3	neutral	0.70	deleterious	-0.73	medium_impact	0.04	medium_impact	-2.58	low_impact	0.15	0.8	1.73	7.38	0.46	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5157	5157	C	G	MI.14209	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	688	230	L	V	Cta/Gta	-4.58	0	0	possibly_damaging	0.87	neutral	0.52	neutral	4.46	neutral	-1.37	deleterious	-2.84	medium_impact	2.44	0.86	neutral	0.17	damaging	3.49	23.10	deleterious	0.21	0.45	0.79	disease	0.29	neutral	0.68	disease	0.62	disease	2	0.86	neutral	0.33	neutral	0	NA	0.71	deleterious	-1.55	low_impact	0.23	medium_impact	0.91	medium_impact	0.41	0.8	0.58	7.05	0.26	N	0.60	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9195	9195	C	A	MI.1421	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	669	223	H	Q	caC/caA	5.68	1	0	probably_damaging	0.99	neutral	1	neutral	4.47	neutral	1.54	deleterious	-2.78	neutral_impact	-1.94	0.87	neutral	0.85	neutral	1.47	13.13	neutral	0.78	0.8	NA	NA	0.03	neutral	0.24	neutral	0.19	neutral	6	0.99	deleterious	0.51	deleterious	-2	neutral	0.68	deleterious	-2.65	low_impact	1.98	high_impact	-2.76	low_impact	0.53	0.9	NA	NA	0.48	N	0.77	disease_causing	0.68	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5157	5157	C	A	MI.14210	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	688	230	L	M	Cta/Ata	-4.58	0	0	possibly_damaging	0.71	neutral	0.39	neutral	4.48	neutral	-1.18	neutral	-1.88	low_impact	1.56	0.89	neutral	0.45	neutral	2.75	21.10	deleterious	0.23	0.45	0.87	disease	0.12	neutral	0.27	neutral	0.44	neutral	1	0.73	neutral	0.34	neutral	-3	neutral	0.66	deleterious	-1.15	low_impact	0.1	medium_impact	0.17	medium_impact	0.42	0.8	0.58	7.05	0.42	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5158	5158	T	A	MI.14211	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	689	230	L	Q	cTa/cAa	-0.89	0	0	probably_damaging	0.99	neutral	0.28	neutral	4.36	deleterious	-3.79	deleterious	-5.62	medium_impact	3.06	0.82	neutral	0.12	damaging	4.32	24.00	deleterious	0.02	0.35	0.9	disease	0.71	disease	0.67	disease	0.7	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-2.62	low_impact	-0.02	medium_impact	1.43	medium_impact	0.21	0.8	0.58	7.05	0.27	N	0.94	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5158	5158	T	C	MI.14212	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	689	230	L	P	cTa/cCa	-0.89	0	0	probably_damaging	0.99	neutral	0.26	neutral	4.35	deleterious	-4.39	deleterious	-6.54	medium_impact	3.21	0.76	neutral	0.1	damaging	4.06	23.70	deleterious	0.02	0.35	0.94	disease	0.74	disease	0.8	disease	0.8	disease	6	0.99	deleterious	0.14	neutral	1	deleterious	0.86	deleterious	-2.62	low_impact	-0.04	medium_impact	1.56	medium_impact	0.15	0.8	0.58	7.05	0.33	N	0.88	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5158	5158	T	G	MI.14213	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	689	230	L	R	cTa/cGa	-0.89	0	0	probably_damaging	0.99	neutral	0.34	neutral	4.36	deleterious	-3.69	deleterious	-5.62	high_impact	3.76	0.75	neutral	0.1	damaging	4.22	23.90	deleterious	0.01	0.35	0.9	disease	0.72	disease	0.8	disease	0.76	disease	5	0.99	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-2.62	low_impact	0.05	medium_impact	2.02	high_impact	0.17	0.8	0.58	7.05	0.37	N	0.95	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5160	5160	T	C	MI.14214	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	691	231	S	P	Tct/Cct	-1.35	0	0	probably_damaging	0.9	neutral	0.21	neutral	4.54	neutral	-2.52	deleterious	-4.39	low_impact	1.71	0.8	neutral	0.36	neutral	3.80	23.40	deleterious	0.09	0.35	0.97	disease	0.78	disease	0.74	disease	0.74	disease	5	0.94	neutral	0.16	neutral	-2	neutral	0.84	deleterious	-1.67	low_impact	-0.11	medium_impact	0.3	medium_impact	0.16	0.8	0.29	9.24	0.28	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5160	5160	T	G	MI.14215	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	691	231	S	A	Tct/Gct	-1.35	0	0	benign	0.06	neutral	0.54	neutral	4.62	neutral	-0.24	neutral	-2.14	neutral_impact	0.7	0.92	neutral	0.94	neutral	0.59	8.12	deleterious	0.38	0.5	0.44	neutral	0.12	neutral	0.22	neutral	0.3	neutral	4	0.4	neutral	0.74	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	0.25	medium_impact	-0.56	medium_impact	0.27	0.8	0.29	9.24	0.36	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5160	5160	T	A	MI.14216	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	691	231	S	T	Tct/Act	-1.35	0	0	benign	0.1	neutral	0.43	neutral	4.57	neutral	-1.12	deleterious	-2.52	low_impact	0.88	0.93	neutral	0.91	neutral	0.73	9.04	deleterious	0.31	0.5	0.85	disease	0.19	neutral	0.22	neutral	0.53	disease	1	0.51	neutral	0.67	deleterious	-6	neutral	0.22	neutral	0.08	medium_impact	0.14	medium_impact	-0.4	medium_impact	0.36	0.8	0.29	9.24	0.4	N	0.15	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5161	5161	C	A	MI.14217	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	692	231	S	Y	tCt/tAt	-0.66	0	0	probably_damaging	0.95	neutral	1	neutral	4.53	deleterious	-3.01	deleterious	-5.35	low_impact	1.78	0.91	neutral	0.42	neutral	4.11	23.70	deleterious	0.1	0.4	0.99	disease	0.62	disease	0.64	disease	0.81	disease	6	0.95	neutral	0.53	deleterious	-2	neutral	0.81	deleterious	-1.97	low_impact	1.87	high_impact	0.35	medium_impact	0.17	0.8	0.29	9.24	0.25	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5161	5161	C	G	MI.14218	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	692	231	S	C	tCt/tGt	-0.66	0	0	probably_damaging	0.97	neutral	0.17	neutral	4.52	deleterious	-4.4	deleterious	-4.27	medium_impact	3.1	0.8	neutral	0.39	neutral	3.53	23.10	deleterious	0.12	0.4	0.98	disease	0.63	disease	0.58	disease	0.8	disease	6	0.98	deleterious	0.1	neutral	1	deleterious	0.79	deleterious	-2.18	low_impact	-0.17	medium_impact	1.47	medium_impact	0.24	0.8	0.29	9.24	0.35	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5161	5161	C	T	MI.14219	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	692	231	S	F	tCt/tTt	-0.66	0	0	probably_damaging	0.93	neutral	0.72	neutral	4.55	neutral	-2.07	deleterious	-5.34	low_impact	1.21	0.89	neutral	0.42	neutral	4.10	23.70	deleterious	0.13	0.4	0.99	disease	0.62	disease	0.65	disease	0.81	disease	6	0.92	neutral	0.4	neutral	-2	neutral	0.80	deleterious	-1.83	low_impact	0.44	medium_impact	-0.13	medium_impact	0.05	0.8	0.29	9.24	0.29	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9195	9195	C	G	MI.1422	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	669	223	H	Q	caC/caG	5.68	1	0	probably_damaging	0.99	neutral	1	neutral	4.47	neutral	1.54	deleterious	-2.78	neutral_impact	-1.94	0.87	neutral	0.85	neutral	1.14	11.42	neutral	0.78	0.8	NA	NA	0.03	neutral	0.24	neutral	0.19	neutral	6	0.99	deleterious	0.51	deleterious	-2	neutral	0.68	deleterious	-2.65	low_impact	1.98	high_impact	-2.76	low_impact	0.53	0.9	NA	NA	0.48	N	0.77	disease_causing	0.68	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5163	5163	C	G	MI.14220	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	694	232	R	G	Cgc/Ggc	-9.18	0	0	benign	0.19	neutral	0.35	neutral	4.9	neutral	0.03	neutral	-2.17	neutral_impact	-0.34	0.9	neutral	0.64	neutral	2.76	21.10	deleterious	0.1	0.4	0.59	disease	0.24	neutral	0.42	neutral	0.53	disease	1	0.58	neutral	0.58	deleterious	-6	neutral	0.40	neutral	-0.22	medium_impact	0.06	medium_impact	-1.43	low_impact	0.19	0.8	13.54	8.77	0.37	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5163	5163	C	T	MI.14221	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	694	232	R	C	Cgc/Tgc	-9.18	0	0	possibly_damaging	0.89	neutral	0.18	neutral	4.55	deleterious	-5.97	deleterious	-2.7	neutral_impact	-0.14	0.83	neutral	0.28	neutral	3.83	23.40	deleterious	0.1	0.4	0.86	disease	0.44	neutral	0.36	neutral	0.68	disease	4	0.94	neutral	0.15	neutral	-3	neutral	0.72	deleterious	-1.63	low_impact	-0.16	medium_impact	-1.26	low_impact	0.76	0.85	13.54	8.77	0.32	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5163	5163	C	A	MI.14222	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	694	232	R	S	Cgc/Agc	-9.18	0	0	benign	0.19	neutral	0.51	neutral	4.72	neutral	-1.66	neutral	-0.91	neutral_impact	-1.5	0.82	neutral	0.75	neutral	2.91	21.90	deleterious	0.14	0.4	0.63	disease	0.17	neutral	0.21	neutral	0.44	neutral	1	0.39	neutral	0.66	deleterious	-6	neutral	0.35	neutral	-0.22	medium_impact	0.22	medium_impact	-2.41	low_impact	0.26	0.8	13.54	8.77	0.35	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5164	5164	G	C	MI.14223	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	695	232	R	P	cGc/cCc	0.03	0	0	possibly_damaging	0.72	neutral	0.23	neutral	4.57	deleterious	-3.79	neutral	-2.19	neutral_impact	0.2	0.74	neutral	0.28	neutral	2.96	22.10	deleterious	0.04	0.35	0.63	disease	0.62	disease	0.53	disease	0.6	disease	2	0.83	neutral	0.26	neutral	-3	neutral	0.73	deleterious	-1.17	low_impact	-0.08	medium_impact	-0.98	medium_impact	0.13	0.8	13.54	8.77	0.29	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5164	5164	G	A	MI.14224	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	695	232	R	H	cGc/cAc	0.03	0	0	benign	0.01	neutral	0.54	neutral	4.58	deleterious	-3.01	neutral	2.76	neutral_impact	-1.12	0.9	neutral	0.94	neutral	1.81	15.04	deleterious	0.23	0.45	0.45	neutral	0.1	neutral	0.11	neutral	0.31	neutral	4	0.45	neutral	0.77	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.25	medium_impact	-2.09	low_impact	0.68	0.85	13.54	8.77	0.37	N	0.23	polymorphism	1	0.01	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5164	5164	G	T	MI.14225	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	695	232	R	L	cGc/cTc	0.03	0	0	benign	0.01	neutral	0.75	neutral	4.59	deleterious	-3.11	neutral	-1.87	neutral_impact	-1.64	0.9	neutral	0.91	neutral	1.85	15.29	deleterious	0.1	0.4	0.46	neutral	0.28	neutral	0.15	neutral	0.44	neutral	1	0.22	neutral	0.87	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	0.47	medium_impact	-2.53	low_impact	0.06	0.8	13.54	8.77	0.36	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5166	5166	A	T	MI.14226	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	697	233	T	S	Acc/Tcc	-11.48	0	0	benign	0.04	neutral	0.42	neutral	4.61	neutral	-0.71	neutral	-1.46	neutral_impact	0.7	0.93	neutral	0.96	neutral	-0.45	0.29	neutral	0.39	0.5	0.79	disease	0.05	neutral	0.23	neutral	0.37	neutral	3	0.55	neutral	0.69	deleterious	-6	neutral	0.22	neutral	0.47	medium_impact	0.13	medium_impact	-0.56	medium_impact	0.46	0.8	6.34	7.53	0.47	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5166	5166	A	C	MI.14227	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	697	233	T	P	Acc/Ccc	-11.48	0	0	possibly_damaging	0.81	neutral	0.21	neutral	4.56	neutral	-2.69	deleterious	-3.53	medium_impact	2.68	0.84	neutral	0.35	neutral	0.86	9.84	deleterious	0.06	0.35	0.91	disease	0.69	disease	0.5	neutral	0.63	disease	3	0.88	neutral	0.2	neutral	0	NA	0.81	deleterious	-1.37	low_impact	-0.11	medium_impact	1.11	medium_impact	0.33	0.8	6.34	7.53	0.33	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5166	5166	A	G	MI.14228	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	697	233	T	A	Acc/Gcc	-11.48	0	0	benign	0.02	neutral	0.51	neutral	4.62	neutral	-0.43	neutral	-2.03	low_impact	1.21	0.95	neutral	0.97	neutral	0.31	5.81	deleterious	0.26	0.45	0.72	disease	0.12	neutral	0.35	neutral	0.45	neutral	1	0.46	neutral	0.75	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	0.22	medium_impact	-0.13	medium_impact	0.28	0.8	6.34	7.53	0.37	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5167	5167	C	T	MI.14229	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	698	233	T	I	aCc/aTc	-0.89	0	0	possibly_damaging	0.81	neutral	0.4	neutral	4.66	neutral	0.27	neutral	-2.48	low_impact	1.37	0.91	neutral	0.68	neutral	1.33	12.42	neutral	0.17	0.45	0.55	disease	0.37	neutral	0.41	neutral	0.58	disease	2	0.81	neutral	0.3	neutral	-3	neutral	0.68	deleterious	-1.37	low_impact	0.11	medium_impact	0.01	medium_impact	0.36	0.8	6.34	7.53	0.38	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9196	9196	G	C	MI.1423	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	670	224	D	H	Gac/Cac	-0.8	0.08	0	possibly_damaging	0.8	deleterious	0	neutral	4.28	deleterious	-4.9	deleterious	-3.75	medium_impact	2.88	0.81	neutral	0.36	neutral	3.75	23.30	deleterious	0.48	0.65	NA	NA	0.23	neutral	0.58	disease	0.38	neutral	3	1	deleterious	0.1	neutral	4	deleterious	0.62	deleterious	-1.33	low_impact	-1.4	low_impact	1.37	medium_impact	0.50	0.9	NA	NA	0.38	N	0.89	polymorphism	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5167	5167	C	G	MI.14230	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	698	233	T	S	aCc/aGc	-0.89	0	0	benign	0.04	neutral	0.42	neutral	4.61	neutral	-0.71	neutral	-1.46	neutral_impact	0.7	0.93	neutral	0.96	neutral	-0.29	0.71	neutral	0.39	0.5	0.79	disease	0.05	neutral	0.23	neutral	0.37	neutral	3	0.55	neutral	0.69	deleterious	-6	neutral	0.22	neutral	0.47	medium_impact	0.13	medium_impact	-0.56	medium_impact	0.46	0.8	6.34	7.53	0.47	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5167	5167	C	A	MI.14231	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	698	233	T	N	aCc/aAc	-0.89	0	0	possibly_damaging	0.58	neutral	0.31	neutral	4.57	neutral	-2.38	deleterious	-2.79	low_impact	1.73	0.86	neutral	0.54	neutral	0.82	9.59	deleterious	0.31	0.45	0.95	disease	0.51	disease	0.55	disease	0.81	disease	6	0.7	neutral	0.37	neutral	-3	neutral	0.75	deleterious	-0.93	medium_impact	0.02	medium_impact	0.31	medium_impact	0.48	0.8	6.34	7.53	0.35	N	0.65	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5169	5169	T	C	MI.14232	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	700	234	W	R	Tga/Cga	-1.58	0	0	probably_damaging	1	neutral	0.34	neutral	4.71	neutral	-1.73	deleterious	-11.72	high_impact	3.75	0.92	neutral	0.13	damaging	3.64	23.20	deleterious	0.05	0.35	0.81	disease	0.77	disease	0.86	disease	0.76	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.05	medium_impact	2.01	high_impact	0.11	0.8	NA	NA	0.52	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5169	5169	T	G	MI.14233	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	700	234	W	G	Tga/Gga	-1.58	0	0	probably_damaging	1	neutral	0.36	neutral	4.66	neutral	-0.07	deleterious	-10.53	medium_impact	2.65	0.94	neutral	0.13	damaging	4.02	23.60	deleterious	0.06	0.35	0.69	disease	0.69	disease	0.84	disease	0.72	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.07	medium_impact	1.09	medium_impact	0.13	0.8	NA	NA	0.43	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5170	5170	G	C	MI.14234	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	701	234	W	S	tGa/tCa	7.4	1	0	probably_damaging	1	neutral	0.54	neutral	4.77	neutral	-1.22	deleterious	-11.26	medium_impact	1.94	0.9	neutral	0.57	neutral	3.05	22.40	deleterious	0.08	0.35	0.43	neutral	0.76	disease	0.8	disease	0.59	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.25	medium_impact	0.49	medium_impact	0.15	0.8	NA	NA	0.54	P	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5170	5170	G	T	MI.14235	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	701	234	W	L	tGa/tTa	7.4	1	0	probably_damaging	1	neutral	0.99	neutral	4.81	neutral	1	deleterious	-11.01	medium_impact	2.02	0.87	neutral	0.11	damaging	4.32	24.00	deleterious	0.12	0.4	0.5	neutral	0.71	disease	0.81	disease	0.7	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.74	deleterious	-3.54	low_impact	1.32	medium_impact	0.56	medium_impact	0.10	0.8	NA	NA	0.53	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5171	5171	A	C	MI.14236	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	702	234	W	C	tgA/tgC	4.63	1	0	probably_damaging	1	neutral	0.17	neutral	4.63	deleterious	-3.12	deleterious	-10.9	medium_impact	3.21	0.92	neutral	0.16	damaging	4.09	23.70	deleterious	0.06	0.35	0.84	disease	0.77	disease	0.81	disease	0.72	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.17	medium_impact	1.56	medium_impact	0.11	0.8	NA	NA	0.61	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5171	5171	A	T	MI.14237	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	702	234	W	C	tgA/tgT	4.63	1	0	probably_damaging	1	neutral	0.17	neutral	4.63	deleterious	-3.12	deleterious	-10.9	medium_impact	3.21	0.92	neutral	0.16	damaging	4.26	23.90	deleterious	0.06	0.35	0.84	disease	0.77	disease	0.81	disease	0.72	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.17	medium_impact	1.56	medium_impact	0.11	0.8	NA	NA	0.61	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5172	5172	A	G	MI.14238	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	703	235	N	D	Aac/Gac	1.64	1	0	probably_damaging	1	neutral	0.25	neutral	4.54	neutral	-0.82	deleterious	-4.66	medium_impact	2.79	0.89	neutral	0.15	damaging	4.00	23.60	deleterious	0.74	0.75	0.79	disease	0.32	neutral	0.49	neutral	0.64	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.06	medium_impact	1.2	medium_impact	0.32	0.8	NA	NA	0.58	P	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5172	5172	A	C	MI.14239	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	703	235	N	H	Aac/Cac	1.64	1	0	probably_damaging	1	neutral	0.54	neutral	4.54	neutral	-1.98	deleterious	-4.69	medium_impact	1.98	0.89	neutral	0.15	damaging	3.27	22.80	deleterious	0.5	0.6	0.85	disease	0.34	neutral	0.38	neutral	0.65	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.25	medium_impact	0.52	medium_impact	0.11	0.8	NA	NA	0.45	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9196	9196	G	T	MI.1424	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	670	224	D	Y	Gac/Tac	-0.8	0.08	0	possibly_damaging	0.89	deleterious	0	neutral	4.2	deleterious	-6.13	deleterious	-5.59	medium_impact	2.88	0.84	neutral	0.44	neutral	4.11	23.70	deleterious	0.22	0.65	NA	NA	0.4	neutral	0.57	disease	0.37	neutral	3	1	deleterious	0.06	neutral	4	deleterious	0.71	deleterious	-1.62	low_impact	-1.4	low_impact	1.37	medium_impact	0.35	0.9	NA	NA	0.42	N	0.98	polymorphism	0.98	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5172	5172	A	T	MI.14240	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	703	235	N	Y	Aac/Tac	1.64	1	0	probably_damaging	1	neutral	1	neutral	4.55	neutral	-2.79	deleterious	-7.46	medium_impact	2.16	0.87	neutral	0.12	damaging	3.88	23.50	deleterious	0.22	0.45	0.74	disease	0.42	neutral	0.48	neutral	0.64	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.74	deleterious	-3.54	low_impact	1.87	high_impact	0.67	medium_impact	0.20	0.8	NA	NA	0.38	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5173	5173	A	G	MI.14241	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	704	235	N	S	aAc/aGc	1.18	0.99	0	probably_damaging	1	neutral	0.5	neutral	4.57	neutral	-0.38	deleterious	-4.49	low_impact	0.84	0.83	neutral	0.47	neutral	2.01	16.30	deleterious	0.72	0.75	0.68	disease	0.13	neutral	0.29	neutral	0.44	neutral	1	1	deleterious	0.25	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.21	medium_impact	-0.44	medium_impact	0.15	0.8	NA	NA	0.44	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5173	5173	A	C	MI.14242	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	704	235	N	T	aAc/aCc	1.18	0.99	0	probably_damaging	1	neutral	0.49	neutral	4.58	neutral	-1.2	deleterious	-5.42	neutral_impact	0.64	0.88	neutral	0.35	neutral	2.23	17.70	deleterious	0.49	0.55	0.5	disease	0.04	neutral	0.21	neutral	0.22	neutral	6	1	deleterious	0.25	neutral	-2	neutral	0.66	deleterious	-3.54	low_impact	0.2	medium_impact	-0.61	medium_impact	0.20	0.8	NA	NA	0.46	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5173	5173	A	T	MI.14243	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	704	235	N	I	aAc/aTc	1.18	0.99	0	probably_damaging	1	neutral	0.45	neutral	4.57	neutral	-2.64	deleterious	-8.35	low_impact	1.94	0.88	neutral	0.21	damaging	3.90	23.50	deleterious	0.21	0.45	0.41	neutral	0.41	neutral	0.47	neutral	0.48	neutral	1	1	deleterious	0.23	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.16	medium_impact	0.49	medium_impact	0.23	0.8	NA	NA	0.43	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5174	5174	C	A	MI.14244	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	705	235	N	K	aaC/aaA	3.94	0.99	0	probably_damaging	1	neutral	0.4	neutral	4.72	neutral	0.11	deleterious	-5.56	low_impact	1.64	0.84	neutral	0.1	damaging	4.52	24.30	deleterious	0.54	0.6	0.38	neutral	0.37	neutral	0.5	neutral	0.47	neutral	1	1	deleterious	0.2	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.11	medium_impact	0.24	medium_impact	0.50	0.8	NA	NA	0.43	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5174	5174	C	G	MI.14245	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	705	235	N	K	aaC/aaG	3.94	0.99	0	probably_damaging	1	neutral	0.4	neutral	4.72	neutral	0.11	deleterious	-5.56	low_impact	1.64	0.84	neutral	0.1	damaging	4.07	23.70	deleterious	0.54	0.6	0.38	neutral	0.37	neutral	0.5	neutral	0.47	neutral	1	1	deleterious	0.2	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.11	medium_impact	0.24	medium_impact	0.50	0.8	NA	NA	0.43	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5175	5175	A	G	MI.14246	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	706	236	K	E	Aag/Gag	-4.11	0	0	probably_damaging	1	neutral	0.34	neutral	4.58	neutral	-1.5	deleterious	-3.29	medium_impact	2.14	0.85	neutral	0.13	damaging	3.95	23.60	deleterious	0.21	0.45	0.87	disease	0.75	disease	0.7	disease	0.76	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.05	medium_impact	0.66	medium_impact	0.50	0.8	1.73	8	0.26	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5175	5175	A	C	MI.14247	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	706	236	K	Q	Aag/Cag	-4.11	0	0	probably_damaging	1	neutral	0.33	neutral	4.56	neutral	-1.9	deleterious	-3.29	low_impact	1.84	0.86	neutral	0.22	damaging	3.32	22.90	deleterious	0.36	0.5	0.89	disease	0.65	disease	0.53	disease	0.62	disease	2	1	deleterious	0.17	neutral	-2	neutral	0.77	deleterious	-3.54	low_impact	0.04	medium_impact	0.4	medium_impact	0.27	0.8	1.73	8	0.28	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5176	5176	A	T	MI.14248	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	707	236	K	M	aAg/aTg	4.4	0.55	0	probably_damaging	1	neutral	0.24	neutral	4.58	deleterious	-3.83	deleterious	-4.95	low_impact	1.9	0.94	neutral	0.23	damaging	4.17	23.80	deleterious	0.13	0.4	0.85	disease	0.64	disease	0.55	disease	0.62	disease	2	1	deleterious	0.12	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	-0.07	medium_impact	0.46	medium_impact	0.14	0.8	1.73	8	0.5	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5176	5176	A	C	MI.14249	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	707	236	K	T	aAg/aCg	4.4	0.55	0	probably_damaging	1	neutral	0.43	neutral	4.62	neutral	-2.3	deleterious	-4.62	low_impact	1.35	0.93	neutral	0.74	neutral	2.71	20.90	deleterious	0.14	0.4	0.59	disease	0.54	disease	0.4	neutral	0.44	neutral	1	1	deleterious	0.22	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	0.14	medium_impact	-0.01	medium_impact	0.09	0.8	1.73	8	0.43	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9196	9196	G	A	MI.1425	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	670	224	D	N	Gac/Aac	-0.8	0.08	0	benign	0.27	deleterious	0.01	neutral	4.24	deleterious	-3.3	neutral	-2.31	low_impact	1.84	0.91	neutral	0.73	neutral	1.63	14.00	neutral	0.7	0.75	NA	NA	0.24	neutral	0.46	neutral	0.17	neutral	7	0.99	deleterious	0.37	neutral	-2	neutral	0.35	neutral	-0.35	medium_impact	-0.84	medium_impact	0.48	medium_impact	0.61	0.9	NA	NA	0.54	P	0.34	polymorphism	1	0.28	rs374870159	.	.	.	.	.	COSM1155697	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	5177	5177	G	C	MI.14250	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	708	236	K	N	aaG/aaC	1.41	0.41	0	probably_damaging	1	neutral	0.34	neutral	4.61	neutral	-2.18	deleterious	-3.72	low_impact	1.66	0.9	neutral	0.74	neutral	2.98	22.20	deleterious	0.53	0.6	0.8	disease	0.64	disease	0.54	disease	0.56	disease	1	1	deleterious	0.17	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	0.05	medium_impact	0.25	medium_impact	0.20	0.8	1.73	8	0.43	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5177	5177	G	T	MI.14251	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	708	236	K	N	aaG/aaT	1.41	0.41	0	probably_damaging	1	neutral	0.34	neutral	4.61	neutral	-2.18	deleterious	-3.72	low_impact	1.66	0.9	neutral	0.74	neutral	3.10	22.50	deleterious	0.53	0.6	0.8	disease	0.64	disease	0.54	disease	0.56	disease	1	1	deleterious	0.17	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	0.05	medium_impact	0.25	medium_impact	0.20	0.8	1.73	8	0.43	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5178	5178	C	G	MI.14252	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	709	237	L	V	Cta/Gta	0.03	0	1	benign	0.3	neutral	0.51	neutral	4.6	neutral	-2.22	neutral	-0.24	neutral_impact	0.5	0.88	neutral	0.76	neutral	2.36	18.53	deleterious	0.35	0.5	0.54	disease	0.15	neutral	0.6	disease	0.3	neutral	4	0.39	neutral	0.61	deleterious	-6	neutral	0.46	deleterious	-0.46	medium_impact	0.22	medium_impact	-0.72	medium_impact	0.30	0.8	8.65	8.62	0.38	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5178	5178	C	A	MI.14253	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	709	237	L	M	Cta/Ata	0.03	0	1	possibly_damaging	0.9	neutral	0.25	neutral	4.67	neutral	-1.39	neutral	0.39	neutral_impact	0.14	0.99	neutral	0.83	neutral	2.36	18.59	deleterious	0.32	0.5	0.64	disease	0.1	neutral	0.4	neutral	0.43	neutral	1	0.92	neutral	0.18	neutral	-3	neutral	0.63	deleterious	-1.67	low_impact	-0.06	medium_impact	-1.03	low_impact	0.51	0.8	8.65	8.62	0.68	P	0.43	polymorphism	1	0.00	rs28357984	.	.	.	.	.	.	.	.	C5178A	Longevity, Extraversion MI / AMS protection, blood iron metabolism	+	-	Reported, haplogroup D marker	18	N	P	N,P	neutral
chrM	5179	5179	T	C	MI.14254	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	710	237	L	P	cTa/cCa	-4.35	0	0	probably_damaging	0.92	neutral	0.24	neutral	4.53	deleterious	-4.81	neutral	-1.96	neutral_impact	0.66	0.74	neutral	0.36	neutral	3.94	23.50	deleterious	0.03	0.35	0.93	disease	0.7	disease	0.69	disease	0.83	disease	7	0.94	neutral	0.16	neutral	-2	neutral	0.81	deleterious	-1.77	low_impact	-0.07	medium_impact	-0.59	medium_impact	0.12	0.8	8.65	8.62	0.28	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5179	5179	T	G	MI.14255	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	710	237	L	R	cTa/cGa	-4.35	0	0	possibly_damaging	0.9	neutral	0.35	neutral	4.56	neutral	-2.67	neutral	-1.4	low_impact	1.15	0.84	neutral	0.44	neutral	3.23	22.80	deleterious	0.04	0.35	0.9	disease	0.58	disease	0.75	disease	0.77	disease	5	0.9	neutral	0.23	neutral	-3	neutral	0.77	deleterious	-1.67	low_impact	0.06	medium_impact	-0.18	medium_impact	0.19	0.8	8.65	8.62	0.31	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5179	5179	T	A	MI.14256	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	710	237	L	Q	cTa/cAa	-4.35	0	0	possibly_damaging	0.9	neutral	0.3	neutral	4.54	deleterious	-3.85	neutral	-1.12	neutral_impact	0.73	0.87	neutral	0.52	neutral	4.10	23.70	deleterious	0.06	0.35	0.91	disease	0.38	neutral	0.69	disease	0.69	disease	4	0.91	neutral	0.2	neutral	-3	neutral	0.74	deleterious	-1.67	low_impact	0	medium_impact	-0.53	medium_impact	0.12	0.8	8.65	8.62	0.42	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5181	5181	A	C	MI.14257	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	712	238	T	P	Aca/Cca	-6.81	0	0	benign	0.04	neutral	0.28	neutral	5.04	neutral	3.11	neutral	5.83	neutral_impact	-1.54	0.87	neutral	0.96	neutral	0.66	8.57	deleterious	0.07	0.35	0.45	neutral	0.06	neutral	0.18	neutral	0.26	neutral	5	0.7	neutral	0.62	deleterious	-6	neutral	0.15	neutral	0.47	medium_impact	-0.02	medium_impact	-2.44	low_impact	0.29	0.8	0.58	7.2	0.48	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5181	5181	A	G	MI.14258	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	712	238	T	A	Aca/Gca	-6.81	0	0	benign	0.02	neutral	0.56	neutral	4.69	neutral	0.8	neutral	-0.67	low_impact	1.25	0.98	neutral	0.97	neutral	1.56	13.66	neutral	0.29	0.45	0.4	neutral	0.32	neutral	0.53	disease	0.44	neutral	1	0.41	neutral	0.77	deleterious	-6	neutral	0.18	neutral	0.75	medium_impact	0.27	medium_impact	-0.09	medium_impact	0.28	0.8	0.58	7.2	0.33	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5181	5181	A	T	MI.14259	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	712	238	T	S	Aca/Tca	-6.81	0	0	possibly_damaging	0.44	neutral	0.45	neutral	4.66	neutral	0.28	neutral	-0.56	neutral_impact	0.24	0.83	neutral	0.84	neutral	1.63	14.02	neutral	0.44	0.55	0.63	disease	0.36	neutral	0.36	neutral	0.6	disease	2	0.51	neutral	0.51	deleterious	-3	neutral	0.50	deleterious	-0.7	medium_impact	0.16	medium_impact	-0.94	medium_impact	0.39	0.8	0.58	7.2	0.33	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9197	9197	A	C	MI.1426	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	671	224	D	A	gAc/gCc	6.14	1	0	benign	0.27	deleterious	0	neutral	4.26	deleterious	-3.86	deleterious	-4.81	medium_impact	2.88	0.84	neutral	0.48	neutral	2.21	17.60	deleterious	0.38	0.65	NA	NA	0.22	neutral	0.52	disease	0.3	neutral	4	1	deleterious	0.37	neutral	1	deleterious	0.30	neutral	-0.35	medium_impact	-1.4	low_impact	1.37	medium_impact	0.54	0.9	NA	NA	0.61	P	0.80	disease_causing	0.5	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5182	5182	C	A	MI.14260	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	713	238	T	K	aCa/aAa	2.9	0.87	0	possibly_damaging	0.66	neutral	0.35	neutral	4.7	neutral	0.98	neutral	-0.82	neutral_impact	0.24	0.86	neutral	0.52	neutral	3.09	22.50	deleterious	0.13	0.4	0.79	disease	0.61	disease	0.65	disease	0.75	disease	5	0.71	neutral	0.35	neutral	-3	neutral	0.73	deleterious	-1.06	low_impact	0.06	medium_impact	-0.94	medium_impact	0.26	0.8	0.58	7.2	0.32	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5182	5182	C	T	MI.14261	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	713	238	T	M	aCa/aTa	2.9	0.87	0	possibly_damaging	0.9	neutral	0.24	neutral	4.64	neutral	-0.21	neutral	-1.62	neutral_impact	0.62	0.89	neutral	0.54	neutral	4.00	23.60	deleterious	0.26	0.45	0.58	disease	0.5	neutral	0.39	neutral	0.5	disease	0	0.92	neutral	0.17	neutral	-3	neutral	0.71	deleterious	-1.67	low_impact	-0.07	medium_impact	-0.62	medium_impact	0.32	0.8	0.58	7.2	0.43	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5184	5184	T	C	MI.14262	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	715	239	W	R	Tga/Cga	-11.44	0	0	possibly_damaging	0.7	neutral	0.22	neutral	4.66	neutral	1.42	neutral	-1.55	low_impact	0.9	0.87	neutral	0.46	neutral	3.54	23.10	deleterious	0.07	0.35	0.66	disease	0.21	neutral	0.51	disease	0.39	neutral	2	0.82	neutral	0.26	neutral	-3	neutral	0.62	deleterious	-1.13	low_impact	-0.1	medium_impact	-0.39	medium_impact	0.09	0.8	10.37	9.76	0.4	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5184	5184	T	G	MI.14263	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	715	239	W	G	Tga/Gga	-11.44	0	0	possibly_damaging	0.62	neutral	0.35	neutral	4.69	neutral	2.48	deleterious	-2.84	neutral_impact	0.2	0.89	neutral	0.49	neutral	3.92	23.50	deleterious	0.09	0.35	0.62	disease	0.13	neutral	0.53	disease	0.33	neutral	3	0.69	neutral	0.37	neutral	-3	neutral	0.58	deleterious	-0.99	medium_impact	0.06	medium_impact	-0.98	medium_impact	0.13	0.8	10.37	9.76	0.41	N	0.53	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5185	5185	G	T	MI.14264	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	716	239	W	L	tGa/tTa	-6.81	0	0	possibly_damaging	0.45	neutral	1	neutral	4.87	neutral	4.72	neutral	2.71	neutral_impact	-1.51	0.87	neutral	0.96	neutral	1.57	13.67	neutral	0.12	0.4	0.61	disease	0.07	neutral	0.22	neutral	0.26	neutral	5	0.45	neutral	0.78	deleterious	-3	neutral	0.50	deleterious	-0.72	medium_impact	1.87	high_impact	-2.42	low_impact	0.08	0.8	10.37	9.76	0.28	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5185	5185	G	C	MI.14265	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	716	239	W	S	tGa/tCa	-6.81	0	0	possibly_damaging	0.67	neutral	0.4	neutral	4.7	neutral	2.79	neutral	-1.38	neutral_impact	-1.1	0.78	neutral	0.83	neutral	2.90	21.80	deleterious	0.1	0.4	0.4	neutral	0.09	neutral	0.47	neutral	0.29	neutral	4	0.69	neutral	0.37	neutral	-3	neutral	0.55	deleterious	-1.08	low_impact	0.11	medium_impact	-2.07	low_impact	0.13	0.8	10.37	9.76	0.34	N	0.57	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5186	5186	A	C	MI.14266	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	717	239	W	C	tgA/tgC	-0.57	0	0.02	probably_damaging	0.95	neutral	0.11	neutral	4.65	neutral	0.9	neutral	-0.7	low_impact	0.9	0.89	neutral	0.45	neutral	4.01	23.60	deleterious	0.09	0.35	0.6	disease	0.27	neutral	0.49	neutral	0.47	neutral	1	0.98	neutral	0.08	neutral	-2	neutral	0.67	deleterious	-1.97	low_impact	-0.3	medium_impact	-0.39	medium_impact	0.11	0.8	10.37	9.76	0.51	N	0.57	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5186	5186	A	T	MI.14267	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	717	239	W	C	tgA/tgT	-0.57	0	0.02	probably_damaging	0.95	neutral	0.11	neutral	4.65	neutral	0.9	neutral	-0.7	low_impact	0.9	0.89	neutral	0.45	neutral	4.15	23.80	deleterious	0.09	0.35	0.6	disease	0.27	neutral	0.49	neutral	0.47	neutral	1	0.98	neutral	0.08	neutral	-2	neutral	0.67	deleterious	-1.97	low_impact	-0.3	medium_impact	-0.39	medium_impact	0.11	0.8	10.37	9.76	0.51	N	0.57	polymorphism	1	0.06	rs878939965	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5187	5187	C	A	MI.14268	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	718	240	L	M	Cta/Ata	-4.96	0	0	benign	0.24	neutral	0.47	neutral	4.49	neutral	-2.61	neutral	-0.24	neutral_impact	0.18	0.92	neutral	0.81	neutral	1.41	12.82	neutral	0.33	0.5	0.7	disease	0.13	neutral	0.26	neutral	0.36	neutral	3	0.43	neutral	0.62	deleterious	-6	neutral	0.36	neutral	-0.34	medium_impact	0.18	medium_impact	-0.99	medium_impact	0.64	0.8	NA	NA	0.43	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5187	5187	C	G	MI.14269	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	718	240	L	V	Cta/Gta	-4.96	0	0	benign	0.1	neutral	0.38	neutral	4.49	neutral	-1.57	neutral	-0.47	low_impact	1.31	0.95	neutral	0.8	neutral	2.28	18.05	deleterious	0.33	0.5	0.59	disease	0.27	neutral	0.62	disease	0.57	disease	1	0.57	neutral	0.64	deleterious	-6	neutral	0.25	neutral	0.08	medium_impact	0.09	medium_impact	-0.04	medium_impact	0.61	0.8	NA	NA	0.39	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9197	9197	A	G	MI.1427	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	671	224	D	G	gAc/gGc	6.14	1	0	benign	0.34	deleterious	0	neutral	4.22	deleterious	-4.17	deleterious	-4.47	medium_impact	2.52	0.8	neutral	0.46	neutral	2.67	20.60	deleterious	0.43	0.65	NA	NA	0.32	neutral	0.53	disease	0.33	neutral	3	1	deleterious	0.33	neutral	1	deleterious	0.38	neutral	-0.48	medium_impact	-1.4	low_impact	1.06	medium_impact	0.40	0.9	NA	NA	0.57	P	0.69	disease_causing	0.59	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5188	5188	T	C	MI.14270	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	719	240	L	P	cTa/cCa	-3.11	0	0	probably_damaging	0.96	neutral	0.2	neutral	4.39	deleterious	-5.14	deleterious	-4.45	medium_impact	2.01	0.83	neutral	0.39	neutral	3.98	23.60	deleterious	0.03	0.35	0.91	disease	0.72	disease	0.75	disease	0.82	disease	6	0.97	neutral	0.12	neutral	1	deleterious	0.82	deleterious	-2.06	low_impact	-0.13	medium_impact	0.55	medium_impact	0.10	0.8	NA	NA	0.31	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5188	5188	T	G	MI.14271	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	719	240	L	R	cTa/cGa	-3.11	0	0	probably_damaging	0.96	neutral	0.25	neutral	4.43	neutral	-2.4	deleterious	-3.93	medium_impact	2.7	0.85	neutral	0.43	neutral	4.23	23.90	deleterious	0.03	0.35	0.88	disease	0.7	disease	0.75	disease	0.81	disease	6	0.97	neutral	0.15	neutral	1	deleterious	0.80	deleterious	-2.06	low_impact	-0.06	medium_impact	1.13	medium_impact	0.09	0.8	NA	NA	0.32	N	0.87	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5188	5188	T	A	MI.14272	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	719	240	L	Q	cTa/cAa	-3.11	0	0	probably_damaging	0.96	neutral	0.23	neutral	4.43	deleterious	-3.97	deleterious	-3.72	low_impact	1.42	0.86	neutral	0.51	neutral	4.24	23.90	deleterious	0.05	0.35	0.89	disease	0.63	disease	0.63	disease	0.71	disease	4	0.97	neutral	0.14	neutral	-2	neutral	0.75	deleterious	-2.06	low_impact	-0.08	medium_impact	0.05	medium_impact	0.15	0.8	NA	NA	0.32	N	0.85	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5190	5190	A	T	MI.14273	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	721	241	T	S	Aca/Tca	-1.49	0	0	benign	0.05	neutral	0.62	neutral	4.66	neutral	0.04	neutral	-2.09	low_impact	1	0.78	neutral	0.92	neutral	0.42	6.76	deleterious	0.33	0.5	0.54	disease	0.18	neutral	0.3	neutral	0.33	neutral	3	0.31	neutral	0.79	deleterious	-6	neutral	0.19	neutral	0.37	medium_impact	0.33	medium_impact	-0.3	medium_impact	0.55	0.8	9.22	8.54	0.3	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5190	5190	A	C	MI.14274	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	721	241	T	P	Aca/Cca	-1.49	0	0	benign	0.29	neutral	0.25	neutral	4.56	neutral	-2.24	deleterious	-3.9	medium_impact	1.94	0.81	neutral	0.46	neutral	3.15	22.60	deleterious	0.05	0.35	0.79	disease	0.74	disease	0.7	disease	0.76	disease	5	0.7	neutral	0.48	deleterious	-3	neutral	0.56	deleterious	-0.44	medium_impact	-0.06	medium_impact	0.49	medium_impact	0.36	0.8	9.22	8.54	0.27	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5190	5190	A	G	MI.14275	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	721	241	T	A	Aca/Gca	-1.49	0	0	benign	0	neutral	0.64	neutral	4.8	neutral	1.23	neutral	-2.32	low_impact	1.14	0.96	neutral	0.94	neutral	0.34	6.10	deleterious	0.28	0.45	0.41	neutral	0.19	neutral	0.3	neutral	0.36	neutral	3	0.36	neutral	0.82	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.35	medium_impact	-0.19	medium_impact	0.29	0.8	9.22	8.54	0.32	N	0.13	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5191	5191	C	A	MI.14276	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	722	241	T	K	aCa/aAa	0.36	0	0	benign	0.12	neutral	0.3	neutral	4.63	neutral	-0.92	deleterious	-3.67	neutral_impact	0.8	0.86	neutral	0.37	neutral	2.72	20.90	deleterious	0.13	0.4	0.82	disease	0.6	disease	0.69	disease	0.73	disease	5	0.66	neutral	0.59	deleterious	-6	neutral	0.38	neutral	-0.01	medium_impact	0	medium_impact	-0.47	medium_impact	0.34	0.8	9.22	8.54	0.29	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5191	5191	C	T	MI.14277	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	722	241	T	M	aCa/aTa	0.36	0	0	benign	0.01	neutral	0.32	neutral	4.62	neutral	-0.7	neutral	-2.45	low_impact	1.36	0.96	neutral	0.73	neutral	0.76	9.21	deleterious	0.11	0.4	0.5	disease	0.35	neutral	0.3	neutral	0.25	neutral	5	0.67	neutral	0.66	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	0.03	medium_impact	0	medium_impact	0.51	0.8	9.22	8.54	0.38	N	0.13	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5193	5193	C	T	MI.14278	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	724	242	P	S	Ccc/Tcc	-6.12	0	0	probably_damaging	0.95	neutral	0.62	neutral	4.7	neutral	2.32	neutral	0.4	neutral_impact	-2.01	0.78	neutral	0.98	neutral	1.79	14.95	neutral	0.23	0.45	0.38	neutral	0.08	neutral	0.16	neutral	0.26	neutral	5	0.94	neutral	0.34	neutral	-2	neutral	0.62	deleterious	-1.97	low_impact	0.33	medium_impact	-2.84	low_impact	0.08	0.8	9.8	8.71	0.4	N	0.21	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5193	5193	C	G	MI.14279	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	724	242	P	A	Ccc/Gcc	-6.12	0	0	possibly_damaging	0.78	neutral	0.75	neutral	4.75	neutral	2.96	neutral	0.11	neutral_impact	-2.02	0.83	neutral	0.93	neutral	-0.54	0.17	neutral	0.18	0.45	0.48	neutral	0.03	neutral	0.18	neutral	0.2	neutral	6	0.74	neutral	0.49	deleterious	-3	neutral	0.60	deleterious	-1.3	low_impact	0.47	medium_impact	-2.85	low_impact	0.73	0.85	9.8	8.71	0.42	N	0.21	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9197	9197	A	T	MI.1428	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	671	224	D	V	gAc/gTc	6.14	1	0	possibly_damaging	0.67	deleterious	0	neutral	4.21	deleterious	-5.38	deleterious	-5.7	medium_impact	2.88	0.82	neutral	0.48	neutral	3.88	23.50	deleterious	0.27	0.65	NA	NA	0.35	neutral	0.56	disease	0.36	neutral	3	1	deleterious	0.17	neutral	4	deleterious	0.54	deleterious	-1.05	low_impact	-1.4	low_impact	1.37	medium_impact	0.30	0.9	NA	NA	0.56	P	0.97	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5193	5193	C	A	MI.14280	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	724	242	P	T	Ccc/Acc	-6.12	0	0	probably_damaging	0.93	neutral	0.57	neutral	4.8	neutral	3.56	neutral	0.81	neutral_impact	-2	0.85	neutral	0.99	neutral	1.05	10.95	neutral	0.18	0.45	0.36	neutral	0.05	neutral	0.17	neutral	0.23	neutral	5	0.92	neutral	0.32	neutral	-2	neutral	0.61	deleterious	-1.83	low_impact	0.28	medium_impact	-2.83	low_impact	0.63	0.8	9.8	8.71	0.41	N	0.18	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5194	5194	C	G	MI.14281	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	725	242	P	R	cCc/cGc	-3.11	0	0	probably_damaging	0.96	neutral	0.45	neutral	4.65	neutral	0.59	neutral	-1.59	neutral_impact	0	0.89	neutral	0.4	neutral	3.48	23.10	deleterious	0.1	0.4	0.67	disease	0.35	neutral	0.59	disease	0.64	disease	3	0.96	neutral	0.25	neutral	-2	neutral	0.70	deleterious	-2.06	low_impact	0.16	medium_impact	-1.14	low_impact	0.43	0.8	9.8	8.71	0.36	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5194	5194	C	A	MI.14282	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	725	242	P	H	cCc/cAc	-3.11	0	0	probably_damaging	0.98	neutral	0.52	neutral	4.64	neutral	0.05	neutral	-2	neutral_impact	0	0.87	neutral	0.43	neutral	4.11	23.70	deleterious	0.11	0.4	0.74	disease	0.22	neutral	0.53	disease	0.52	disease	0	0.98	deleterious	0.27	neutral	-2	neutral	0.68	deleterious	-2.34	low_impact	0.23	medium_impact	-1.14	low_impact	0.39	0.8	9.8	8.71	0.31	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5194	5194	C	T	MI.14283	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	725	242	P	L	cCc/cTc	-3.11	0	0	benign	0.15	neutral	1	neutral	5.01	neutral	4.79	neutral	-0.73	neutral_impact	-1.84	0.95	neutral	0.89	neutral	0.74	9.07	deleterious	0.12	0.4	0.78	disease	0.21	neutral	0.29	neutral	0.52	disease	0	0.15	neutral	0.93	deleterious	-6	neutral	0.29	neutral	-0.11	medium_impact	1.87	high_impact	-2.69	low_impact	0.76	0.85	9.8	8.71	0.3	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5196	5196	T	A	MI.14284	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	727	243	L	M	Tta/Ata	-10.05	0	0	benign	0.24	neutral	0.38	neutral	4.43	neutral	-2.72	neutral	-0.14	low_impact	0.88	0.88	neutral	0.91	neutral	1.72	14.54	neutral	0.27	0.45	0.72	disease	0.04	neutral	0.16	neutral	0.4	neutral	2	0.54	neutral	0.57	deleterious	-6	neutral	0.36	neutral	-0.34	medium_impact	0.09	medium_impact	-0.4	medium_impact	0.51	0.8	4.32	7.96	0.54	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5196	5196	T	G	MI.14285	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	727	243	L	V	Tta/Gta	-10.05	0	0	benign	0.1	neutral	0.48	neutral	4.53	neutral	-1.03	neutral	-1.25	low_impact	1.46	0.91	neutral	0.48	neutral	2.40	18.85	deleterious	0.25	0.45	0.56	disease	0.18	neutral	0.25	neutral	0.38	neutral	2	0.45	neutral	0.69	deleterious	-6	neutral	0.24	neutral	0.08	medium_impact	0.19	medium_impact	0.09	medium_impact	0.59	0.8	4.32	7.96	0.38	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5197	5197	T	G	MI.14286	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	728	243	L	W	tTa/tGa	-2.65	0	0	probably_damaging	0.98	neutral	0.18	neutral	4.42	deleterious	-5.94	deleterious	-3.73	medium_impact	2.48	0.92	neutral	0.16	damaging	3.80	23.40	deleterious	0.05	0.35	0.96	disease	0.51	disease	0.49	neutral	0.75	disease	5	0.99	deleterious	0.1	neutral	1	deleterious	0.78	deleterious	-2.34	low_impact	-0.16	medium_impact	0.94	medium_impact	0.22	0.8	4.32	7.96	0.45	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5197	5197	T	C	MI.14287	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	728	243	L	S	tTa/tCa	-2.65	0	0	possibly_damaging	0.78	neutral	0.54	neutral	4.51	neutral	-2.91	neutral	-2.47	neutral_impact	0.67	0.85	neutral	0.82	neutral	2.63	20.40	deleterious	0.05	0.35	0.83	disease	0.29	neutral	0.33	neutral	0.6	disease	2	0.75	neutral	0.38	neutral	-3	neutral	0.67	deleterious	-1.3	low_impact	0.25	medium_impact	-0.58	medium_impact	0.20	0.8	4.32	7.96	0.28	N	0.74	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5198	5198	A	T	MI.14288	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	729	243	L	F	ttA/ttT	-0.11	0	0.01	probably_damaging	0.92	neutral	0.85	neutral	4.41	neutral	-2.37	neutral	-2.27	low_impact	1.32	0.91	neutral	0.67	neutral	2.57	19.94	deleterious	0.18	0.45	0.76	disease	0.28	neutral	0.29	neutral	0.58	disease	2	0.91	neutral	0.47	neutral	-2	neutral	0.69	deleterious	-1.77	low_impact	0.63	medium_impact	-0.03	medium_impact	0.61	0.8	4.32	7.96	0.31	N	0.43	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5198	5198	A	C	MI.14289	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	729	243	L	F	ttA/ttC	-0.11	0	0.01	probably_damaging	0.92	neutral	0.85	neutral	4.41	neutral	-2.37	neutral	-2.27	low_impact	1.32	0.91	neutral	0.67	neutral	2.43	19.02	deleterious	0.18	0.45	0.76	disease	0.28	neutral	0.29	neutral	0.58	disease	2	0.91	neutral	0.47	neutral	-2	neutral	0.69	deleterious	-1.77	low_impact	0.63	medium_impact	-0.03	medium_impact	0.61	0.8	4.32	7.96	0.28	N	0.43	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9198	9198	C	A	MI.1429	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	672	224	D	E	gaC/gaA	7.07	1	0	benign	0.01	neutral	1	neutral	4.45	neutral	-1.79	neutral	-0.99	neutral_impact	-1.33	0.87	neutral	0.7	neutral	-0.21	1.05	neutral	0.58	0.7	NA	NA	0.03	neutral	0.23	neutral	0.19	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.14	medium_impact	1.98	high_impact	-2.24	low_impact	0.55	0.9	NA	NA	0.49	N	0.85	polymorphism	0.8	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5199	5199	A	T	MI.14290	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	730	244	I	F	Att/Ttt	-12.13	0	0	possibly_damaging	0.48	neutral	0.55	neutral	4.69	neutral	0.33	neutral	-2.39	low_impact	0.94	0.91	neutral	0.76	neutral	3.73	23.30	deleterious	0.14	0.4	0.81	disease	0.4	neutral	0.29	neutral	0.64	disease	3	0.45	neutral	0.54	deleterious	-3	neutral	0.57	deleterious	-0.77	medium_impact	0.26	medium_impact	-0.35	medium_impact	0.52	0.8	2.88	7.94	0.29	N	0.54	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5199	5199	A	G	MI.14291	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	730	244	I	V	Att/Gtt	-12.13	0	0	benign	0.01	neutral	0.4	neutral	4.57	neutral	-0.76	neutral	-0.44	low_impact	1.36	0.96	neutral	0.9	neutral	1.76	14.72	neutral	0.33	0.5	0.42	neutral	0.12	neutral	0.24	neutral	0.31	neutral	4	0.59	neutral	0.7	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.11	medium_impact	0	medium_impact	0.40	0.8	2.88	7.94	0.49	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5199	5199	A	C	MI.14292	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	730	244	I	L	Att/Ctt	-12.13	0	0	benign	0.06	neutral	1	neutral	4.92	neutral	1.43	neutral	-0.52	neutral_impact	0.32	0.87	neutral	0.94	neutral	2.35	18.51	deleterious	0.22	0.45	0.57	disease	0.11	neutral	0.19	neutral	0.36	neutral	3	0.06	neutral	0.97	deleterious	-6	neutral	0.17	neutral	0.3	medium_impact	1.87	high_impact	-0.88	medium_impact	0.52	0.8	2.88	7.94	0.42	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5200	5200	T	G	MI.14293	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	731	244	I	S	aTt/aGt	-0.57	0	0	benign	0.28	neutral	0.41	neutral	4.49	neutral	-2.54	deleterious	-3.38	low_impact	0.96	0.84	neutral	0.96	neutral	3.32	22.90	deleterious	0.05	0.35	0.54	disease	0.45	neutral	0.31	neutral	0.44	neutral	1	0.5	neutral	0.57	deleterious	-6	neutral	0.44	deleterious	-0.42	medium_impact	0.12	medium_impact	-0.34	medium_impact	0.30	0.8	2.88	7.94	0.35	N	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5200	5200	T	C	MI.14294	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	731	244	I	T	aTt/aCt	-0.57	0	0	benign	0.02	neutral	0.41	neutral	4.52	neutral	-1.57	neutral	-2.24	neutral_impact	0.78	0.96	neutral	0.98	neutral	1.83	15.15	deleterious	0.09	0.35	0.58	disease	0.14	neutral	0.22	neutral	0.32	neutral	4	0.57	neutral	0.7	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	0.12	medium_impact	-0.49	medium_impact	0.31	0.8	2.88	7.94	0.43	N	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5200	5200	T	A	MI.14295	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	731	244	I	N	aTt/aAt	-0.57	0	0	possibly_damaging	0.48	neutral	0.2	neutral	4.47	deleterious	-3.78	deleterious	-4.35	medium_impact	2.62	0.88	neutral	0.44	neutral	4.58	24.40	deleterious	0.11	0.4	0.64	disease	0.59	disease	0.55	disease	0.65	disease	3	0.78	neutral	0.36	neutral	0	NA	0.66	deleterious	-0.77	medium_impact	-0.13	medium_impact	1.06	medium_impact	0.38	0.8	2.88	7.94	0.43	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5201	5201	T	A	MI.14296	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	732	244	I	M	atT/atA	0.59	0	0.01	benign	0.04	neutral	0.27	neutral	4.58	neutral	-0.68	neutral	-0.63	low_impact	0.83	0.96	neutral	0.94	neutral	2.20	17.54	deleterious	0.23	0.45	0.68	disease	0.12	neutral	0.14	neutral	0.39	neutral	2	0.71	neutral	0.62	deleterious	-6	neutral	0.18	neutral	0.47	medium_impact	-0.03	medium_impact	-0.45	medium_impact	0.51	0.8	2.88	7.94	0.51	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5201	5201	T	G	MI.14297	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	732	244	I	M	atT/atG	0.59	0	0.01	benign	0.04	neutral	0.27	neutral	4.58	neutral	-0.68	neutral	-0.63	low_impact	0.83	0.96	neutral	0.94	neutral	1.93	15.77	deleterious	0.23	0.45	0.68	disease	0.12	neutral	0.14	neutral	0.39	neutral	2	0.71	neutral	0.62	deleterious	-6	neutral	0.18	neutral	0.47	medium_impact	-0.03	medium_impact	-0.45	medium_impact	0.51	0.8	2.88	7.94	0.51	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5202	5202	C	T	MI.14298	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	733	245	P	S	Cca/Tca	-8.43	0	0	benign	0.01	neutral	0.48	neutral	4.74	neutral	2.94	neutral	0.6	neutral_impact	0.26	0.96	neutral	0.93	neutral	0.82	9.58	deleterious	0.17	0.45	0.47	neutral	0.11	neutral	0.19	neutral	0.33	neutral	3	0.5	neutral	0.74	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.19	medium_impact	-0.93	medium_impact	0.14	0.8	3.17	8.68	0.5	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5202	5202	C	G	MI.14299	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	733	245	P	A	Cca/Gca	-8.43	0	0	benign	0	neutral	0.33	neutral	4.74	neutral	2.88	neutral	1.02	neutral_impact	0.37	0.97	neutral	0.96	neutral	0.33	6.00	deleterious	0.17	0.45	0.51	disease	0.06	neutral	0.22	neutral	0.24	neutral	5	0.67	neutral	0.67	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.04	medium_impact	-0.83	medium_impact	0.55	0.8	3.17	8.68	0.49	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8594	8594	T	G	MI.143	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	68	23	I	S	aTc/aGc	2.67	0.98	0	possibly_damaging	0.68	neutral	0.56	neutral	4.29	neutral	-1.62	neutral	-2.33	neutral_impact	-0.8	0.79	neutral	0.66	neutral	2.50	19.47	deleterious	0.33	0.65	0.56	disease	0.32	neutral	0.33	neutral	0.61	disease	2	0.64	neutral	0.44	neutral	-3	neutral	0.49	deleterious	-1.07	low_impact	0.35	medium_impact	-1.78	low_impact	0.58	0.9	19.03	10.37	0.36	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9198	9198	C	G	MI.1430	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	672	224	D	E	gaC/gaG	7.07	1	0	benign	0.01	neutral	1	neutral	4.45	neutral	-1.79	neutral	-0.99	neutral_impact	-1.33	0.87	neutral	0.7	neutral	-0.53	0.18	neutral	0.58	0.7	NA	NA	0.03	neutral	0.23	neutral	0.19	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.14	medium_impact	1.98	high_impact	-2.24	low_impact	0.55	0.9	NA	NA	0.49	N	0.85	polymorphism	0.8	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5202	5202	C	A	MI.14300	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	733	245	P	T	Cca/Aca	-8.43	0	0	benign	0.01	neutral	0.25	neutral	4.73	neutral	2.71	neutral	1.43	neutral_impact	0.2	0.9	neutral	0.95	neutral	0.98	10.57	neutral	0.16	0.45	0.53	disease	0.06	neutral	0.18	neutral	0.29	neutral	4	0.74	neutral	0.62	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	-0.06	medium_impact	-0.98	medium_impact	0.56	0.8	3.17	8.68	0.57	P	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5203	5203	C	T	MI.14301	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	734	245	P	L	cCa/cTa	-4.5	0	0	benign	0.01	neutral	1	neutral	4.91	neutral	4.27	neutral	4.13	neutral_impact	-1.24	0.92	neutral	0.98	neutral	1.36	12.58	neutral	0.12	0.4	0.6	disease	0.11	neutral	0.19	neutral	0.34	neutral	3	0.01	neutral	1	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	1.87	high_impact	-2.19	low_impact	0.66	0.8	3.17	8.68	0.3	N	0.19	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5203	5203	C	G	MI.14302	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	734	245	P	R	cCa/cGa	-4.5	0	0	possibly_damaging	0.46	neutral	0.17	neutral	4.65	neutral	0.61	neutral	0.13	medium_impact	2.06	0.9	neutral	0.41	neutral	3.48	23.10	deleterious	0.1	0.4	0.74	disease	0.33	neutral	0.64	disease	0.66	disease	3	0.81	neutral	0.36	neutral	0	NA	0.54	deleterious	-0.73	medium_impact	-0.17	medium_impact	0.59	medium_impact	0.40	0.8	3.17	8.68	0.51	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5203	5203	C	A	MI.14303	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	734	245	P	Q	cCa/cAa	-4.5	0	0	possibly_damaging	0.46	neutral	0.17	neutral	4.65	neutral	0.45	neutral	0.4	medium_impact	2.06	0.89	neutral	0.5	neutral	3.95	23.60	deleterious	0.12	0.4	0.76	disease	0.17	neutral	0.52	disease	0.47	neutral	1	0.81	neutral	0.36	neutral	0	NA	0.59	deleterious	-0.73	medium_impact	-0.17	medium_impact	0.59	medium_impact	0.39	0.8	3.17	8.68	0.52	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5205	5205	T	A	MI.14304	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	736	246	S	T	Tcc/Acc	-1.26	0	0	benign	0.25	neutral	0.51	neutral	4.66	neutral	0.36	neutral	1.02	neutral_impact	-0.24	0.92	neutral	0.98	neutral	2.02	16.32	deleterious	0.26	0.45	0.74	disease	0.07	neutral	0.14	neutral	0.44	neutral	1	0.39	neutral	0.63	deleterious	-6	neutral	0.39	neutral	-0.36	medium_impact	0.22	medium_impact	-1.35	low_impact	0.54	0.8	0.86	7.55	0.46	N	0.15	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5205	5205	T	G	MI.14305	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	736	246	S	A	Tcc/Gcc	-1.26	0	0	benign	0.01	neutral	0.69	neutral	4.65	neutral	0.08	neutral	0.41	neutral_impact	-0.19	0.96	neutral	0.96	neutral	2.51	19.55	deleterious	0.24	0.45	0.4	neutral	0.12	neutral	0.18	neutral	0.32	neutral	4	0.29	neutral	0.84	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.4	medium_impact	-1.3	low_impact	0.43	0.8	0.86	7.55	0.38	N	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5205	5205	T	C	MI.14306	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	736	246	S	P	Tcc/Ccc	-1.26	0	0	benign	0.02	neutral	0.37	neutral	4.59	neutral	-2.2	neutral	-1.22	low_impact	1.47	0.95	neutral	0.62	neutral	4.03	23.70	deleterious	0.06	0.35	0.9	disease	0.64	disease	0.56	disease	0.71	disease	4	0.62	neutral	0.68	deleterious	-6	neutral	0.29	neutral	0.75	medium_impact	0.08	medium_impact	0.09	medium_impact	0.38	0.8	0.86	7.55	0.3	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5206	5206	C	T	MI.14307	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	737	246	S	F	tCc/tTc	-3.58	0	0	benign	0.02	neutral	0.37	neutral	4.69	neutral	0.82	neutral	-0.04	neutral_impact	-0.34	0.95	neutral	0.84	neutral	3.17	22.70	deleterious	0.09	0.35	0.46	neutral	0.36	neutral	0.37	neutral	0.46	neutral	1	0.62	neutral	0.68	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	0.08	medium_impact	-1.43	low_impact	0.16	0.8	0.86	7.55	0.36	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5206	5206	C	A	MI.14308	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	737	246	S	Y	tCc/tAc	-3.58	0	0	benign	0.4	neutral	0.26	neutral	4.61	neutral	-1.16	neutral	-0.55	low_impact	0.92	0.9	neutral	0.62	neutral	4.22	23.90	deleterious	0.07	0.35	0.55	disease	0.34	neutral	0.48	neutral	0.59	disease	2	0.7	neutral	0.43	neutral	-6	neutral	0.45	deleterious	-0.64	medium_impact	-0.04	medium_impact	-0.37	medium_impact	0.31	0.8	0.86	7.55	0.46	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5206	5206	C	G	MI.14309	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	737	246	S	C	tCc/tGc	-3.58	0	0	possibly_damaging	0.89	neutral	0.09	neutral	4.62	neutral	-0.74	neutral	-0.27	neutral_impact	0.57	0.81	neutral	0.48	neutral	3.62	23.20	deleterious	0.07	0.35	0.85	disease	0.37	neutral	0.42	neutral	0.66	disease	3	0.97	neutral	0.1	neutral	-3	neutral	0.69	deleterious	-1.63	low_impact	-0.35	medium_impact	-0.67	medium_impact	0.25	0.8	0.86	7.55	0.4	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9199	9199	A	T	MI.1431	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	673	225	N	Y	Aac/Tac	-1.03	0.02	0	probably_damaging	0.99	neutral	0.16	neutral	4.52	neutral	-2.9	deleterious	-6.88	high_impact	3.57	0.55	damaging	0.36	neutral	3.78	23.40	deleterious	0.46	0.65	NA	NA	0.49	neutral	0.63	disease	0.53	disease	1	1	deleterious	0.09	neutral	2	deleterious	0.75	deleterious	-2.65	low_impact	-0.12	medium_impact	1.96	medium_impact	0.56	0.9	NA	NA	0.36	N	1.00	disease_causing	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5208	5208	A	G	MI.14310	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	739	247	T	A	Acc/Gcc	-13.06	0	0	benign	0.01	neutral	0.56	neutral	4.67	neutral	0.34	neutral	-1.64	low_impact	1.48	0.91	neutral	0.67	neutral	0.95	10.37	neutral	0.23	0.45	NA	NA	0.2	neutral	0.5	neutral	0.2	neutral	6	0.42	neutral	0.78	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.27	medium_impact	0.1	medium_impact	0.39	0.8	5.48	7.87	0.34	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5208	5208	A	C	MI.14311	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	739	247	T	P	Acc/Ccc	-13.06	0	0	possibly_damaging	0.57	neutral	0.26	neutral	4.52	neutral	-2.56	deleterious	-3.14	medium_impact	2.87	0.76	neutral	0.31	neutral	3.65	23.20	deleterious	0.06	0.35	NA	NA	0.62	disease	0.72	disease	0.67	disease	3	0.74	neutral	0.35	neutral	0	NA	0.67	deleterious	-0.91	medium_impact	-0.04	medium_impact	1.27	medium_impact	0.45	0.8	5.48	7.87	0.31	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5208	5208	A	T	MI.14312	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	739	247	T	S	Acc/Tcc	-13.06	0	0	benign	0.2	neutral	0.56	neutral	4.6	neutral	-1.28	neutral	-1.75	low_impact	1.05	0.89	neutral	0.94	neutral	0.98	10.52	neutral	0.38	0.5	NA	NA	0.23	neutral	0.39	neutral	0.17	neutral	7	0.33	neutral	0.68	deleterious	-6	neutral	0.34	neutral	-0.25	medium_impact	0.27	medium_impact	-0.26	medium_impact	0.65	0.8	5.48	7.87	0.36	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5209	5209	C	A	MI.14313	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	740	247	T	N	aCc/aAc	-0.57	0	0	possibly_damaging	0.65	neutral	0.33	neutral	4.55	deleterious	-3.48	deleterious	-2.87	low_impact	0.98	0.91	neutral	0.59	neutral	3.39	23.00	deleterious	0.25	0.45	NA	NA	0.45	neutral	0.62	disease	0.42	neutral	2	0.72	neutral	0.34	neutral	-3	neutral	0.64	deleterious	-1.04	low_impact	0.04	medium_impact	-0.32	medium_impact	0.64	0.8	5.48	7.87	0.39	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5209	5209	C	T	MI.14314	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	740	247	T	I	aCc/aTc	-0.57	0	0	benign	0.01	neutral	0.53	neutral	4.65	neutral	-1.16	neutral	-0.26	low_impact	0.81	0.93	neutral	0.94	neutral	0.25	5.17	deleterious	0.12	0.4	NA	NA	0.21	neutral	0.37	neutral	0.19	neutral	6	0.45	neutral	0.76	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.24	medium_impact	-0.46	medium_impact	0.68	0.85	5.48	7.87	0.33	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5209	5209	C	G	MI.14315	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	740	247	T	S	aCc/aGc	-0.57	0	0	benign	0.2	neutral	0.56	neutral	4.6	neutral	-1.28	neutral	-1.75	low_impact	1.05	0.89	neutral	0.94	neutral	0.69	8.78	deleterious	0.38	0.5	NA	NA	0.23	neutral	0.39	neutral	0.17	neutral	7	0.33	neutral	0.68	deleterious	-6	neutral	0.34	neutral	-0.25	medium_impact	0.27	medium_impact	-0.26	medium_impact	0.65	0.8	5.48	7.87	0.36	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5211	5211	C	T	MI.14316	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	742	248	L	F	Ctc/Ttc	-8.66	0	0	probably_damaging	0.95	neutral	0.39	neutral	4.46	neutral	-1.71	deleterious	-3.22	low_impact	1.57	0.91	neutral	0.76	neutral	4.01	23.60	deleterious	0.29	0.45	0.68	disease	0.33	neutral	0.58	disease	0.59	disease	2	0.95	neutral	0.22	neutral	-2	neutral	0.70	deleterious	-1.97	low_impact	0.1	medium_impact	0.18	medium_impact	0.63	0.8	NA	NA	0.41	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5211	5211	C	G	MI.14317	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	742	248	L	V	Ctc/Gtc	-8.66	0	0	possibly_damaging	0.67	neutral	0.3	neutral	4.56	neutral	-1.79	neutral	-2.25	medium_impact	2.87	0.93	neutral	0.54	neutral	3.52	23.10	deleterious	0.37	0.5	0.67	disease	0.29	neutral	0.58	disease	0.55	disease	1	0.75	neutral	0.32	neutral	0	NA	0.64	deleterious	-1.08	low_impact	0	medium_impact	1.27	medium_impact	0.54	0.8	NA	NA	0.44	N	0.61	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5211	5211	C	A	MI.14318	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	742	248	L	I	Ctc/Atc	-8.66	0	0	possibly_damaging	0.77	neutral	0.31	neutral	4.6	neutral	-1.75	neutral	-1.59	low_impact	1.93	0.94	neutral	0.71	neutral	4.14	23.80	deleterious	0.39	0.5	0.55	disease	0.27	neutral	0.56	disease	0.53	disease	1	0.81	neutral	0.27	neutral	-3	neutral	0.64	deleterious	-1.28	low_impact	0.02	medium_impact	0.48	medium_impact	0.61	0.8	NA	NA	0.46	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5212	5212	T	C	MI.14319	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	743	248	L	P	cTc/cCc	0.13	0.01	0	probably_damaging	0.98	neutral	0.16	neutral	4.41	deleterious	-5.26	deleterious	-5.79	high_impact	3.76	0.83	neutral	0.35	neutral	3.99	23.60	deleterious	0.02	0.35	0.45	neutral	0.6	disease	0.77	disease	0.68	disease	4	0.99	deleterious	0.09	neutral	2	deleterious	0.73	deleterious	-2.34	low_impact	-0.19	medium_impact	2.02	high_impact	0.40	0.8	NA	NA	0.43	N	0.90	polymorphism	1	0.29	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9199	9199	A	C	MI.1432	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	673	225	N	H	Aac/Cac	-1.03	0.02	0	probably_damaging	0.99	neutral	0.36	neutral	4.56	neutral	-2.41	deleterious	-4.3	low_impact	1.64	0.55	damaging	0.34	neutral	3.22	22.70	deleterious	0.61	0.7	NA	NA	0.35	neutral	0.62	disease	0.36	neutral	3	0.99	deleterious	0.19	neutral	-2	neutral	0.74	deleterious	-2.65	low_impact	0.15	medium_impact	0.31	medium_impact	0.54	0.9	NA	NA	0.33	N	0.98	disease_causing	0.93	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5212	5212	T	A	MI.14320	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	743	248	L	H	cTc/cAc	0.13	0.01	0	probably_damaging	0.99	neutral	0.22	neutral	4.41	deleterious	-5.21	deleterious	-5.79	high_impact	3.76	0.86	neutral	0.4	neutral	4.20	23.90	deleterious	0.04	0.35	0.92	disease	0.59	disease	0.73	disease	0.73	disease	5	0.99	deleterious	0.12	neutral	2	deleterious	0.77	deleterious	-2.62	low_impact	-0.1	medium_impact	2.02	high_impact	0.29	0.8	NA	NA	0.4	N	0.91	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5212	5212	T	G	MI.14321	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	743	248	L	R	cTc/cGc	0.13	0.01	0	probably_damaging	0.97	neutral	0.18	neutral	4.42	deleterious	-4.69	deleterious	-4.83	high_impact	3.76	0.84	neutral	0.39	neutral	4.28	24.00	deleterious	0.02	0.35	0.88	disease	0.66	disease	0.76	disease	0.67	disease	3	0.98	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-2.18	low_impact	-0.16	medium_impact	2.02	high_impact	0.28	0.8	NA	NA	0.45	N	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5214	5214	C	T	MI.14322	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	745	249	L	F	Ctc/Ttc	-13.06	0	0	possibly_damaging	0.88	neutral	0.74	neutral	4.3	neutral	-1.52	deleterious	-3.21	medium_impact	2.42	0.84	neutral	0.45	neutral	4.07	23.70	deleterious	0.12	0.4	0.81	disease	0.32	neutral	0.51	disease	0.6	disease	2	0.86	neutral	0.43	neutral	0	NA	0.72	deleterious	-1.59	low_impact	0.46	medium_impact	0.89	medium_impact	0.48	0.8	NA	NA	0.25	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5214	5214	C	G	MI.14323	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	745	249	L	V	Ctc/Gtc	-13.06	0	0	possibly_damaging	0.54	neutral	0.52	neutral	4.23	neutral	-2.86	neutral	-2.23	medium_impact	2.77	0.87	neutral	0.52	neutral	3.52	23.10	deleterious	0.16	0.45	0.68	disease	0.28	neutral	0.68	disease	0.57	disease	1	0.52	neutral	0.49	deleterious	0	NA	0.61	deleterious	-0.86	medium_impact	0.23	medium_impact	1.19	medium_impact	0.55	0.8	NA	NA	0.26	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5214	5214	C	A	MI.14324	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	745	249	L	I	Ctc/Atc	-13.06	0	0	possibly_damaging	0.66	neutral	0.36	neutral	4.21	neutral	-2.68	neutral	-1.61	medium_impact	2.38	0.88	neutral	0.62	neutral	4.20	23.90	deleterious	0.19	0.45	0.62	disease	0.24	neutral	0.6	disease	0.53	disease	1	0.7	neutral	0.35	neutral	0	NA	0.61	deleterious	-1.06	low_impact	0.07	medium_impact	0.86	medium_impact	0.61	0.8	NA	NA	0.37	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5215	5215	T	C	MI.14325	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	746	249	L	P	cTc/cCc	-2.19	0	0	probably_damaging	0.97	neutral	0.23	neutral	4.14	deleterious	-6.25	deleterious	-5.78	high_impact	3.92	0.74	neutral	0.3	neutral	3.96	23.60	deleterious	0.02	0.35	0.96	disease	0.6	disease	0.78	disease	0.8	disease	6	0.98	neutral	0.13	neutral	2	deleterious	0.82	deleterious	-2.18	low_impact	-0.08	medium_impact	2.16	high_impact	0.20	0.8	NA	NA	0.38	N	0.89	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5215	5215	T	G	MI.14326	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	746	249	L	R	cTc/cGc	-2.19	0	0	probably_damaging	0.93	neutral	0.33	neutral	4.15	deleterious	-5.69	deleterious	-4.82	high_impact	3.92	0.79	neutral	0.35	neutral	4.28	24.00	deleterious	0.02	0.35	0.95	disease	0.66	disease	0.78	disease	0.8	disease	6	0.94	neutral	0.2	neutral	2	deleterious	0.83	deleterious	-1.83	low_impact	0.04	medium_impact	2.16	high_impact	0.20	0.8	NA	NA	0.42	N	0.94	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5215	5215	T	A	MI.14327	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	746	249	L	H	cTc/cAc	-2.19	0	0	probably_damaging	0.98	neutral	0.48	neutral	4.14	deleterious	-6.22	deleterious	-5.78	high_impact	3.92	0.82	neutral	0.38	neutral	4.20	23.90	deleterious	0.03	0.35	0.91	disease	0.59	disease	0.75	disease	0.69	disease	4	0.98	neutral	0.25	neutral	2	deleterious	0.79	deleterious	-2.34	low_impact	0.19	medium_impact	2.16	high_impact	0.28	0.8	NA	NA	0.4	N	0.88	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5217	5217	T	A	MI.14328	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	748	250	S	T	Tcc/Acc	-3.11	0	0	probably_damaging	1	neutral	0.39	neutral	4.27	deleterious	-3.58	deleterious	-2.87	medium_impact	3.15	0.95	neutral	0.22	damaging	3.84	23.40	deleterious	0.13	0.4	0.66	disease	0.42	neutral	0.7	disease	0.58	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.1	medium_impact	1.51	medium_impact	0.65	0.8	NA	NA	0.42	N	0.71	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5217	5217	T	G	MI.14329	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	748	250	S	A	Tcc/Gcc	-3.11	0	0	probably_damaging	1	neutral	0.51	neutral	4.41	neutral	-0.94	deleterious	-2.86	medium_impact	3.07	0.87	neutral	0.21	damaging	3.73	23.30	deleterious	0.14	0.4	0.48	neutral	0.3	neutral	0.6	disease	0.43	neutral	1	0.99	deleterious	0.26	neutral	1	deleterious	0.71	deleterious	-3.54	low_impact	0.22	medium_impact	1.44	medium_impact	0.35	0.8	NA	NA	0.31	N	0.49	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9199	9199	A	G	MI.1433	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	673	225	N	D	Aac/Gac	-1.03	0.02	0	probably_damaging	0.95	deleterious	0.04	neutral	4.57	neutral	-0.89	deleterious	-4.28	medium_impact	2.67	0.69	neutral	0.47	neutral	3.94	23.50	deleterious	0.73	0.8	NA	NA	0.34	neutral	0.62	disease	0.39	neutral	2	0.99	deleterious	0.05	neutral	5	deleterious	0.71	deleterious	-1.97	low_impact	-0.49	medium_impact	1.19	medium_impact	0.61	0.9	NA	NA	0.39	N	0.96	disease_causing	0.86	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5217	5217	T	C	MI.14330	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	748	250	S	P	Tcc/Ccc	-3.11	0	0	probably_damaging	1	neutral	0.21	neutral	4.22	deleterious	-5.58	deleterious	-4.79	medium_impact	3.49	0.84	neutral	0.09	damaging	4.02	23.60	deleterious	0.04	0.35	0.67	disease	0.65	disease	0.8	disease	0.7	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.11	medium_impact	1.79	medium_impact	0.34	0.8	NA	NA	0.38	N	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5218	5218	C	A	MI.14331	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	749	250	S	Y	tCc/tAc	5.68	1	0	probably_damaging	1	neutral	1	neutral	4.22	deleterious	-5.25	deleterious	-5.74	high_impact	4.04	0.89	neutral	0.08	damaging	4.16	23.80	deleterious	0.04	0.35	0.83	disease	0.64	disease	0.71	disease	0.67	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.77	deleterious	-3.54	low_impact	1.87	high_impact	2.26	high_impact	0.19	0.8	NA	NA	0.56	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5218	5218	C	G	MI.14332	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	749	250	S	C	tCc/tGc	5.68	1	0	probably_damaging	1	neutral	0.18	neutral	4.24	deleterious	-5.45	deleterious	-4.79	high_impact	4.04	0.87	neutral	0.1	damaging	3.69	23.30	deleterious	0.04	0.35	0.92	disease	0.57	disease	0.67	disease	0.7	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	-0.16	medium_impact	2.26	high_impact	0.24	0.8	NA	NA	0.67	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5218	5218	C	T	MI.14333	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	749	250	S	F	tCc/tTc	5.68	1	0	probably_damaging	1	neutral	0.7	neutral	4.28	deleterious	-4.77	deleterious	-5.74	high_impact	4.04	0.8	neutral	0.07	damaging	4.35	24.10	deleterious	0.03	0.35	0.39	neutral	0.66	disease	0.71	disease	0.67	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.71	deleterious	-3.54	low_impact	0.41	medium_impact	2.26	high_impact	0.09	0.8	NA	NA	0.5	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5220	5220	C	G	MI.14334	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	751	251	L	V	Cta/Gta	-10.75	0	0	possibly_damaging	0.79	neutral	0.52	neutral	4.32	deleterious	-3	neutral	-2.24	high_impact	3.56	0.89	neutral	0.55	neutral	3.51	23.10	deleterious	0.28	0.45	0.81	disease	0.4	neutral	0.69	disease	0.65	disease	3	0.77	neutral	0.37	neutral	1	deleterious	0.68	deleterious	-1.32	low_impact	0.23	medium_impact	1.85	medium_impact	0.50	0.8	0.86	7.54	0.38	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5220	5220	C	A	MI.14335	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	751	251	L	M	Cta/Ata	-10.75	0	0	possibly_damaging	0.46	neutral	0.26	neutral	4.29	neutral	-2.11	neutral	-0.47	low_impact	1.63	0.87	neutral	0.87	neutral	2.55	19.81	deleterious	0.35	0.5	0.68	disease	0.22	neutral	0.44	neutral	0.47	neutral	1	0.71	neutral	0.4	neutral	-3	neutral	0.57	deleterious	-0.73	medium_impact	-0.04	medium_impact	0.23	medium_impact	0.57	0.8	0.86	7.54	0.47	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5221	5221	T	G	MI.14336	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	752	251	L	R	cTa/cGa	-0.57	0	0	probably_damaging	0.98	neutral	0.36	neutral	4.24	deleterious	-5.58	deleterious	-4.8	high_impact	3.91	0.86	neutral	0.38	neutral	4.25	23.90	deleterious	0.02	0.35	0.75	disease	0.75	disease	0.78	disease	0.69	disease	4	0.98	neutral	0.19	neutral	2	deleterious	0.80	deleterious	-2.34	low_impact	0.07	medium_impact	2.15	high_impact	0.12	0.8	0.86	7.54	0.49	N	0.95	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5221	5221	T	A	MI.14337	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	752	251	L	Q	cTa/cAa	-0.57	0	0	probably_damaging	0.98	neutral	0.3	neutral	4.24	deleterious	-5.63	deleterious	-4.51	high_impact	3.91	0.86	neutral	0.47	neutral	4.14	23.80	deleterious	0.03	0.35	0.68	disease	0.65	disease	0.68	disease	0.65	disease	3	0.98	neutral	0.16	neutral	2	deleterious	0.74	deleterious	-2.34	low_impact	0	medium_impact	2.15	high_impact	0.26	0.8	0.86	7.54	0.43	N	0.95	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5221	5221	T	C	MI.14338	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	752	251	L	P	cTa/cCa	-0.57	0	0	probably_damaging	0.99	neutral	0.28	neutral	4.23	deleterious	-6.15	deleterious	-5.74	high_impact	3.91	0.83	neutral	0.36	neutral	3.98	23.60	deleterious	0.02	0.35	0.52	disease	0.66	disease	0.78	disease	0.68	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.76	deleterious	-2.62	low_impact	-0.02	medium_impact	2.15	high_impact	0.27	0.8	0.86	7.54	0.44	N	0.88	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5223	5223	G	T	MI.14339	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	754	252	G	W	Gga/Tga	-0.11	0.48	0	probably_damaging	1	neutral	0.19	neutral	4.53	deleterious	-4.15	deleterious	-7.66	high_impact	3.86	0.84	neutral	0.07	damaging	4.47	24.20	deleterious	0.08	0.35	0.79	disease	0.84	disease	0.72	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.14	medium_impact	2.11	high_impact	0.08	0.8	NA	NA	0.38	N	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9200	9200	A	C	MI.1434	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	674	225	N	T	aAc/aCc	6.84	1	0	probably_damaging	0.97	neutral	0.11	neutral	4.6	neutral	-0.45	deleterious	-5.1	medium_impact	2.21	0.59	damaging	0.48	neutral	3.60	23.20	deleterious	0.59	0.7	NA	NA	0.38	neutral	0.58	disease	0.38	neutral	2	0.99	deleterious	0.07	neutral	1	deleterious	0.72	deleterious	-2.19	low_impact	-0.22	medium_impact	0.8	medium_impact	0.60	0.9	NA	NA	0.55	P	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5223	5223	G	C	MI.14340	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	754	252	G	R	Gga/Cga	-0.11	0.48	0	probably_damaging	1	neutral	0.35	neutral	4.55	neutral	-2.81	deleterious	-7.66	high_impact	3.51	0.81	neutral	0.06	damaging	3.96	23.60	deleterious	0.05	0.35	0.71	disease	0.87	disease	0.78	disease	0.72	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	0.06	medium_impact	1.81	medium_impact	0.50	0.8	NA	NA	0.38	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5224	5224	G	T	MI.14341	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	755	252	G	V	gGa/gTa	7.07	1	0	probably_damaging	1	neutral	0.52	neutral	4.65	neutral	0.25	deleterious	-8.62	high_impact	3.86	0.85	neutral	0.08	damaging	3.84	23.40	deleterious	0.07	0.35	0.7	disease	0.79	disease	0.67	disease	0.66	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.23	medium_impact	2.11	high_impact	0.11	0.8	NA	NA	0.56	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5224	5224	G	C	MI.14342	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	755	252	G	A	gGa/gCa	7.07	1	0	probably_damaging	1	neutral	0.55	neutral	4.68	neutral	2.52	deleterious	-5.74	low_impact	1.47	0.87	neutral	0.23	damaging	3.15	22.60	deleterious	0.17	0.45	0.43	neutral	0.14	neutral	0.38	neutral	0.28	neutral	4	1	deleterious	0.28	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.26	medium_impact	0.09	medium_impact	0.30	0.8	NA	NA	0.52	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5224	5224	G	A	MI.14343	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	755	252	G	E	gGa/gAa	7.07	1	0	probably_damaging	1	neutral	0.27	neutral	4.55	deleterious	-3	deleterious	-7.66	high_impact	3.86	0.84	neutral	0.06	damaging	3.96	23.60	deleterious	0.06	0.35	0.38	neutral	0.83	disease	0.76	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	-0.03	medium_impact	2.11	high_impact	0.20	0.8	NA	NA	0.62	P	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5226	5226	G	C	MI.14344	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	757	253	G	R	Ggc/Cgc	-0.34	0.39	0	probably_damaging	1	neutral	0.35	neutral	3.6	deleterious	-10.56	deleterious	-7.66	high_impact	4.06	0.81	neutral	0.1	damaging	4.05	23.70	deleterious	0.01	0.35	0.7	disease	0.85	disease	0.83	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.06	medium_impact	2.27	high_impact	0.57	0.8	0.58	7.14	0.43	N	1.00	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5226	5226	G	A	MI.14345	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	757	253	G	S	Ggc/Agc	-0.34	0.39	0	probably_damaging	1	neutral	0.4	neutral	3.68	deleterious	-6.89	deleterious	-5.75	high_impact	3.51	0.86	neutral	0.14	damaging	4.23	23.90	deleterious	0.02	0.35	0.33	neutral	0.75	disease	0.7	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.74	deleterious	-3.54	low_impact	0.11	medium_impact	1.81	medium_impact	0.61	0.8	0.58	7.14	0.36	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5226	5226	G	T	MI.14346	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	757	253	G	C	Ggc/Tgc	-0.34	0.39	0	probably_damaging	1	neutral	0.18	neutral	3.59	deleterious	-10.11	deleterious	-8.62	high_impact	4.06	0.78	neutral	0.09	damaging	4.28	24.00	deleterious	0.02	0.35	0.94	disease	0.83	disease	0.75	disease	0.66	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.16	medium_impact	2.27	high_impact	0.22	0.8	0.58	7.14	0.39	N	0.96	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5227	5227	G	C	MI.14347	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	758	253	G	A	gGc/gCc	7.3	1	0	probably_damaging	1	neutral	0.51	neutral	3.82	deleterious	-6.34	deleterious	-5.75	high_impact	4.06	0.83	neutral	0.13	damaging	3.17	22.70	deleterious	0.03	0.35	0.39	neutral	0.62	disease	0.68	disease	0.65	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	0.22	medium_impact	2.27	high_impact	0.40	0.8	0.58	7.14	0.56	P	0.74	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5227	5227	G	T	MI.14348	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	758	253	G	V	gGc/gTc	7.3	1	0	probably_damaging	1	neutral	0.5	neutral	3.61	deleterious	-9.34	deleterious	-8.62	high_impact	4.06	0.68	neutral	0.1	damaging	3.84	23.40	deleterious	0.02	0.35	0.65	disease	0.82	disease	0.77	disease	0.7	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.21	medium_impact	2.27	high_impact	0.21	0.8	0.58	7.14	0.61	P	0.97	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5227	5227	G	A	MI.14349	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	758	253	G	D	gGc/gAc	7.3	1	0	probably_damaging	1	neutral	0.2	neutral	3.6	deleterious	-10.05	deleterious	-6.7	high_impact	4.06	0.81	neutral	0.1	damaging	3.97	23.60	deleterious	0.01	0.35	0.61	disease	0.83	disease	0.83	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.13	medium_impact	2.27	high_impact	0.13	0.8	0.58	7.14	0.59	P	0.95	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9200	9200	A	G	MI.1435	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	674	225	N	S	aAc/aGc	6.84	1	0	probably_damaging	0.95	neutral	0.18	neutral	4.64	neutral	0.33	deleterious	-4.19	low_impact	0.94	0.75	neutral	0.59	neutral	3.29	22.80	deleterious	0.71	0.75	NA	NA	0.29	neutral	0.53	disease	0.34	neutral	3	0.97	neutral	0.12	neutral	-2	neutral	0.73	deleterious	-1.97	low_impact	-0.08	medium_impact	-0.29	medium_impact	0.43	0.9	NA	NA	0.56	P	0.82	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5229	5229	C	G	MI.14350	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	760	254	L	V	Ctg/Gtg	-6.12	0	0	probably_damaging	1	neutral	0.55	neutral	4.41	neutral	-1.21	deleterious	-2.87	medium_impact	3.06	0.91	neutral	0.14	damaging	3.49	23.10	deleterious	0.13	0.4	NA	NA	0.39	neutral	0.68	disease	0.41	neutral	2	1	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.26	medium_impact	1.43	medium_impact	0.65	0.8	NA	NA	0.28	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5229	5229	C	A	MI.14351	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	760	254	L	M	Ctg/Atg	-6.12	0	0	probably_damaging	1	neutral	0.24	neutral	4.35	neutral	-2.34	neutral	-1.92	medium_impact	2.08	0.85	neutral	0.11	damaging	3.82	23.40	deleterious	0.15	0.4	NA	NA	0.38	neutral	0.55	disease	0.36	neutral	3	1	deleterious	0.12	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.07	medium_impact	0.61	medium_impact	0.61	0.8	NA	NA	0.32	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5230	5230	T	A	MI.14352	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	761	254	L	Q	cTg/cAg	0.59	0.13	0	probably_damaging	1	neutral	0.33	neutral	4.3	deleterious	-5.26	deleterious	-5.75	high_impact	3.96	0.83	neutral	0.11	damaging	4.25	23.90	deleterious	0.02	0.35	NA	NA	0.68	disease	0.69	disease	0.66	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.04	medium_impact	2.19	high_impact	0.37	0.8	NA	NA	0.36	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5230	5230	T	C	MI.14353	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	761	254	L	P	cTg/cCg	0.59	0.13	0	probably_damaging	1	neutral	0.36	neutral	4.3	deleterious	-5.64	deleterious	-6.7	high_impact	3.62	0.81	neutral	0.09	damaging	3.97	23.60	deleterious	0.02	0.35	NA	NA	0.63	disease	0.67	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.07	medium_impact	1.9	medium_impact	0.17	0.8	NA	NA	0.32	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5230	5230	T	G	MI.14354	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	761	254	L	R	cTg/cGg	0.59	0.13	0	probably_damaging	1	neutral	0.38	neutral	4.3	deleterious	-5.09	deleterious	-5.75	high_impact	3.96	0.81	neutral	0.09	damaging	4.27	23.90	deleterious	0.01	0.35	NA	NA	0.74	disease	0.78	disease	0.69	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.09	medium_impact	2.19	high_impact	0.19	0.8	NA	NA	0.39	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5232	5232	C	T	MI.14355	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	763	255	P	S	Ccc/Tcc	-16.07	0	0	probably_damaging	1	neutral	0.49	neutral	3.54	deleterious	-7.55	deleterious	-7.66	high_impact	4.04	0.84	neutral	0.16	damaging	3.96	23.60	deleterious	0.05	0.35	0.56	disease	0.66	disease	0.75	disease	0.69	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	0.2	medium_impact	2.26	high_impact	0.18	0.8	NA	NA	0.33	N	0.72	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5232	5232	C	G	MI.14356	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	763	255	P	A	Ccc/Gcc	-16.07	0	0	probably_damaging	1	neutral	0.58	neutral	3.56	deleterious	-7.04	deleterious	-7.66	high_impact	3.69	0.85	neutral	0.17	damaging	3.16	22.60	deleterious	0.07	0.35	0.62	disease	0.52	disease	0.76	disease	0.7	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	0.29	medium_impact	1.96	medium_impact	0.48	0.8	NA	NA	0.28	N	0.72	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5232	5232	C	A	MI.14357	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	763	255	P	T	Ccc/Acc	-16.07	0	0	probably_damaging	1	neutral	0.45	neutral	3.54	deleterious	-7.99	deleterious	-7.66	medium_impact	3.48	0.83	neutral	0.12	damaging	3.76	23.30	deleterious	0.05	0.35	0.8	disease	0.63	disease	0.76	disease	0.67	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.16	medium_impact	1.79	medium_impact	0.43	0.8	NA	NA	0.29	N	0.88	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5233	5233	C	T	MI.14358	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	764	255	P	L	cCc/cTc	5.45	0.99	0	probably_damaging	1	neutral	0.75	neutral	3.62	deleterious	-8	deleterious	-9.58	high_impact	3.69	0.92	neutral	0.12	damaging	4.50	24.30	deleterious	0.05	0.35	0.69	disease	0.76	disease	0.72	disease	0.68	disease	4	1	deleterious	0.38	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	0.47	medium_impact	1.96	medium_impact	0.56	0.8	NA	NA	0.54	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5233	5233	C	A	MI.14359	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	764	255	P	H	cCc/cAc	5.45	0.99	0	probably_damaging	1	neutral	0.55	neutral	3.52	deleterious	-10.38	deleterious	-8.62	high_impact	4.04	0.84	neutral	0.1	damaging	4.05	23.70	deleterious	0.05	0.35	0.89	disease	0.76	disease	0.81	disease	0.67	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.26	medium_impact	2.26	high_impact	0.32	0.8	NA	NA	0.61	P	0.71	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9200	9200	A	T	MI.1436	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	674	225	N	I	aAc/aTc	6.84	1	0	probably_damaging	0.99	neutral	0.1	neutral	4.54	neutral	-2.04	deleterious	-7.73	low_impact	1.54	0.62	neutral	0.53	neutral	4.23	23.90	deleterious	0.45	0.65	NA	NA	0.52	disease	0.61	disease	0.66	disease	3	1	deleterious	0.06	neutral	-2	neutral	0.75	deleterious	-2.65	low_impact	-0.25	medium_impact	0.22	medium_impact	0.49	0.9	NA	NA	0.49	P	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5233	5233	C	G	MI.14360	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	764	255	P	R	cCc/cGc	5.45	0.99	0	probably_damaging	1	neutral	0.39	neutral	3.53	deleterious	-9.61	deleterious	-8.62	high_impact	4.04	0.85	neutral	0.12	damaging	3.64	23.20	deleterious	0.04	0.35	0.69	disease	0.78	disease	0.83	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.1	medium_impact	2.26	high_impact	0.30	0.8	NA	NA	0.63	P	0.56	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5235	5235	C	G	MI.14361	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	766	256	P	A	Ccg/Gcg	-12.13	0	0	probably_damaging	1	neutral	0.5	neutral	4.36	deleterious	-3.7	deleterious	-7.66	high_impact	4.04	0.83	neutral	0.16	damaging	3.16	22.60	deleterious	0.08	0.35	0.52	disease	0.55	disease	0.73	disease	0.69	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.74	deleterious	-3.54	low_impact	0.21	medium_impact	2.26	high_impact	0.66	0.8	NA	NA	0.33	N	0.72	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5235	5235	C	A	MI.14362	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	766	256	P	T	Ccg/Acg	-12.13	0	0	probably_damaging	1	neutral	0.39	neutral	4.35	deleterious	-4.19	deleterious	-7.66	medium_impact	3.34	0.83	neutral	0.12	damaging	3.76	23.40	deleterious	0.06	0.35	0.35	neutral	0.67	disease	0.74	disease	0.68	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.1	medium_impact	1.67	medium_impact	0.51	0.8	NA	NA	0.31	N	0.88	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5235	5235	C	T	MI.14363	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	766	256	P	S	Ccg/Tcg	-12.13	0	0	probably_damaging	1	neutral	0.4	neutral	4.34	deleterious	-4.33	deleterious	-7.66	high_impact	4.04	0.83	neutral	0.16	damaging	3.98	23.60	deleterious	0.07	0.35	0.65	disease	0.69	disease	0.73	disease	0.69	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	0.11	medium_impact	2.26	high_impact	0.14	0.8	NA	NA	0.34	N	0.72	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5236	5236	C	G	MI.14364	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	767	256	P	R	cCg/cGg	5.45	1	0	probably_damaging	1	neutral	0.35	neutral	4.32	deleterious	-5.56	deleterious	-8.62	high_impact	4.04	0.85	neutral	0.12	damaging	3.68	23.30	deleterious	0.04	0.35	0.75	disease	0.82	disease	0.82	disease	0.68	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.06	medium_impact	2.26	high_impact	0.26	0.8	NA	NA	0.63	P	0.56	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5236	5236	C	T	MI.14365	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	767	256	P	L	cCg/cTg	5.45	1	0	probably_damaging	1	neutral	0.66	neutral	4.46	neutral	-2.02	deleterious	-9.57	medium_impact	3.48	0.76	neutral	0.11	damaging	4.48	24.20	deleterious	0.06	0.35	0.39	neutral	0.79	disease	0.7	disease	0.67	disease	3	1	deleterious	0.33	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.37	medium_impact	1.79	medium_impact	0.50	0.8	NA	NA	0.44	N	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5236	5236	C	A	MI.14366	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	767	256	P	Q	cCg/cAg	5.45	1	0	probably_damaging	1	neutral	0.29	neutral	4.31	deleterious	-5.69	deleterious	-7.66	high_impact	4.04	0.83	neutral	0.11	damaging	4.16	23.80	deleterious	0.06	0.35	0.53	disease	0.79	disease	0.75	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	-0.01	medium_impact	2.26	high_impact	0.32	0.8	NA	NA	0.58	P	0.83	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5238	5238	C	G	MI.14367	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	769	257	L	V	Cta/Gta	-4.73	0	0	probably_damaging	1	neutral	0.47	neutral	4.36	neutral	-2.62	deleterious	-2.87	high_impact	3.78	0.85	neutral	0.14	damaging	3.50	23.10	deleterious	0.21	0.45	NA	NA	0.5	neutral	0.67	disease	0.61	disease	2	1	deleterious	0.24	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	0.18	medium_impact	2.04	high_impact	0.49	0.8	NA	NA	0.33	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5238	5238	C	A	MI.14368	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	769	257	L	M	Cta/Ata	-4.73	0	0	probably_damaging	1	neutral	0.23	neutral	4.3	neutral	-2.69	neutral	-1.92	medium_impact	2.13	0.91	neutral	0.21	damaging	3.80	23.40	deleterious	0.29	0.45	NA	NA	0.36	neutral	0.44	neutral	0.15	neutral	7	1	deleterious	0.12	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.08	medium_impact	0.65	medium_impact	0.63	0.8	NA	NA	0.43	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5239	5239	T	C	MI.14369	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	770	257	L	P	cTa/cCa	-0.11	0	0	probably_damaging	1	neutral	0.29	neutral	4.25	deleterious	-5.61	deleterious	-6.7	high_impact	3.78	0.82	neutral	0.11	damaging	3.96	23.60	deleterious	0.02	0.35	NA	NA	0.77	disease	0.64	disease	0.65	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.01	medium_impact	2.04	high_impact	0.25	0.8	NA	NA	0.31	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9201	9201	C	A	MI.1437	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	675	225	N	K	aaC/aaA	6.84	1	0	probably_damaging	0.97	neutral	0.05	neutral	4.62	neutral	-0.72	deleterious	-5.13	low_impact	1.49	0.62	neutral	0.43	neutral	4.58	24.40	deleterious	0.73	0.75	NA	NA	0.41	neutral	0.59	disease	0.38	neutral	2	0.99	deleterious	0.04	neutral	-2	neutral	0.75	deleterious	-2.19	low_impact	-0.43	medium_impact	0.18	medium_impact	0.84	0.9	NA	NA	0.52	P	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5239	5239	T	G	MI.14370	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	770	257	L	R	cTa/cGa	-0.11	0	0	probably_damaging	1	neutral	0.29	neutral	4.26	deleterious	-5.03	deleterious	-5.74	high_impact	3.78	0.8	neutral	0.11	damaging	4.24	23.90	deleterious	0.02	0.35	NA	NA	0.83	disease	0.76	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.01	medium_impact	2.04	high_impact	0.13	0.8	NA	NA	0.36	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5239	5239	T	A	MI.14371	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	770	257	L	Q	cTa/cAa	-0.11	0	0	probably_damaging	1	neutral	0.26	neutral	4.26	deleterious	-5.2	deleterious	-5.74	high_impact	3.78	0.86	neutral	0.14	damaging	4.12	23.80	deleterious	0.03	0.35	NA	NA	0.73	disease	0.66	disease	0.65	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	-0.04	medium_impact	2.04	high_impact	0.29	0.8	NA	NA	0.34	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5241	5241	A	T	MI.14372	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	772	258	T	S	Acc/Tcc	-1.96	0	0	benign	0.18	neutral	0.43	neutral	4.68	neutral	2.08	neutral	-0.91	neutral_impact	0.63	0.9	neutral	0.88	neutral	-0.37	0.45	neutral	0.3	0.45	0.38	neutral	0.18	neutral	0.42	neutral	0.25	neutral	5	0.49	neutral	0.63	deleterious	-6	neutral	0.32	neutral	-0.19	medium_impact	0.14	medium_impact	-0.61	medium_impact	0.63	0.8	NA	NA	0.47	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5241	5241	A	G	MI.14373	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	772	258	T	A	Acc/Gcc	-1.96	0	0	possibly_damaging	0.62	neutral	0.52	neutral	4.7	neutral	2.43	deleterious	-2.64	low_impact	1.92	0.87	neutral	0.65	neutral	1.75	14.70	neutral	0.23	0.45	0.51	disease	0.57	disease	0.6	disease	0.54	disease	1	0.58	neutral	0.45	neutral	-3	neutral	0.63	deleterious	-0.99	medium_impact	0.23	medium_impact	0.47	medium_impact	0.31	0.8	NA	NA	0.3	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5241	5241	A	C	MI.14374	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	772	258	T	P	Acc/Ccc	-1.96	0	0	probably_damaging	0.95	neutral	0.22	neutral	4.52	neutral	-1.06	deleterious	-4.04	medium_impact	2.76	0.78	neutral	0.32	neutral	3.33	22.90	deleterious	0.05	0.35	0.87	disease	0.84	disease	0.68	disease	0.65	disease	3	0.97	neutral	0.14	neutral	1	deleterious	0.80	deleterious	-1.97	low_impact	-0.1	medium_impact	1.18	medium_impact	0.43	0.8	NA	NA	0.28	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5242	5242	C	T	MI.14375	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	773	258	T	I	aCc/aTc	0.13	0.01	0	probably_damaging	0.95	neutral	0.41	neutral	4.59	neutral	0.44	deleterious	-4.41	low_impact	1.61	0.85	neutral	0.47	neutral	3.72	23.30	deleterious	0.11	0.4	0.39	neutral	0.79	disease	0.68	disease	0.66	disease	3	0.95	neutral	0.23	neutral	-2	neutral	0.71	deleterious	-1.97	low_impact	0.12	medium_impact	0.21	medium_impact	0.58	0.8	NA	NA	0.27	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5242	5242	C	A	MI.14376	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	773	258	T	N	aCc/aAc	0.13	0.01	0	possibly_damaging	0.82	neutral	0.32	neutral	4.53	neutral	0.57	deleterious	-2.7	medium_impact	3.31	0.86	neutral	0.48	neutral	2.11	16.92	deleterious	0.22	0.45	0.63	disease	0.79	disease	0.69	disease	0.66	disease	3	0.84	neutral	0.25	neutral	0	NA	0.73	deleterious	-1.4	low_impact	0.03	medium_impact	1.64	medium_impact	0.49	0.8	NA	NA	0.32	N	0.76	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5242	5242	C	G	MI.14377	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	773	258	T	S	aCc/aGc	0.13	0.01	0	benign	0.18	neutral	0.43	neutral	4.68	neutral	2.08	neutral	-0.91	neutral_impact	0.63	0.9	neutral	0.88	neutral	-0.21	1.04	neutral	0.3	0.45	0.38	neutral	0.18	neutral	0.42	neutral	0.25	neutral	5	0.49	neutral	0.63	deleterious	-6	neutral	0.32	neutral	-0.19	medium_impact	0.14	medium_impact	-0.61	medium_impact	0.63	0.8	NA	NA	0.45	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5244	5244	G	T	MI.14378	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	775	259	G	C	Ggc/Tgc	-4.96	0	0	probably_damaging	1	neutral	0.18	neutral	4.21	deleterious	-7.72	deleterious	-8.62	high_impact	4.01	0.44	damaging	0.02	damaging	4.21	23.90	deleterious	0.03	0.35	0.94	disease	0.9	disease	0.78	disease	0.64	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	-0.16	medium_impact	2.23	high_impact	0.24	0.8	NA	NA	0.43	N	0.96	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5244	5244	G	C	MI.14379	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	775	259	G	R	Ggc/Cgc	-4.96	0	0	probably_damaging	1	neutral	0.35	neutral	4.24	deleterious	-6.53	deleterious	-7.66	high_impact	4.01	0.51	damaging	0.02	damaging	4.02	23.60	deleterious	0.03	0.35	0.68	disease	0.91	disease	0.86	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	0.06	medium_impact	2.23	high_impact	0.66	0.8	NA	NA	0.37	N	1.00	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9201	9201	C	G	MI.1438	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	675	225	N	K	aaC/aaG	6.84	1	0	probably_damaging	0.97	neutral	0.05	neutral	4.62	neutral	-0.72	deleterious	-5.13	low_impact	1.49	0.62	neutral	0.43	neutral	4.14	23.80	deleterious	0.73	0.75	NA	NA	0.41	neutral	0.59	disease	0.38	neutral	2	0.99	deleterious	0.04	neutral	-2	neutral	0.75	deleterious	-2.19	low_impact	-0.43	medium_impact	0.18	medium_impact	0.84	0.9	NA	NA	0.52	P	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5244	5244	G	A	MI.14380	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	775	259	G	S	Ggc/Agc	-4.96	0	0	probably_damaging	1	neutral	0.4	neutral	4.31	deleterious	-5.14	deleterious	-5.75	high_impact	3.67	0.27	damaging	0.02	damaging	4.23	23.90	deleterious	0.05	0.35	0.54	disease	0.85	disease	0.78	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.11	medium_impact	1.95	medium_impact	0.70	0.85	NA	NA	0.77	P	0.98	disease_causing_automatic	0	0.18	rs199476115	Pathogenic	Leber's_optic_atrophy	24756	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	G5244A	LHON	-	+	Reported	7	P	P	P	damaging
chrM	5245	5245	G	T	MI.14381	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	776	259	G	V	gGc/gTc	7.3	1	0	probably_damaging	1	neutral	0.5	neutral	4.23	deleterious	-5.08	deleterious	-8.62	high_impact	4.01	0.37	damaging	0.02	damaging	3.86	23.50	deleterious	0.03	0.35	0.66	disease	0.91	disease	0.81	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.21	medium_impact	2.23	high_impact	0.20	0.8	NA	NA	0.71	P	0.97	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5245	5245	G	A	MI.14382	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	776	259	G	D	gGc/gAc	7.3	1	0	probably_damaging	1	neutral	0.2	neutral	4.23	deleterious	-6.88	deleterious	-6.7	high_impact	4.01	0.48	damaging	0.02	damaging	3.87	23.50	deleterious	0.03	0.35	0.62	disease	0.9	disease	0.85	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.13	medium_impact	2.23	high_impact	0.21	0.8	NA	NA	0.64	P	0.95	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5245	5245	G	C	MI.14383	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	776	259	G	A	gGc/gCc	7.3	1	0	probably_damaging	1	neutral	0.51	neutral	4.26	deleterious	-5.23	deleterious	-5.75	high_impact	4.01	0.34	damaging	0.03	damaging	3.21	22.70	deleterious	0.06	0.35	0.61	disease	0.77	disease	0.77	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.22	medium_impact	2.23	high_impact	0.45	0.8	NA	NA	0.74	P	0.74	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5247	5247	T	C	MI.14384	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	778	260	F	L	Ttt/Ctt	-5.89	0	0	probably_damaging	1	neutral	0.67	neutral	3.51	deleterious	-7.35	deleterious	-5.75	medium_impact	3.31	0.57	damaging	0.05	damaging	4.23	23.90	deleterious	0.03	0.35	0.38	neutral	0.81	disease	0.78	disease	0.69	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.38	medium_impact	1.64	medium_impact	0.54	0.8	NA	NA	0.39	N	0.91	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5247	5247	T	A	MI.14385	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	778	260	F	I	Ttt/Att	-5.89	0	0	probably_damaging	1	neutral	0.45	neutral	3.4	deleterious	-8.75	deleterious	-5.75	high_impact	4.01	0.6	damaging	0.06	damaging	4.54	24.30	deleterious	0.04	0.35	0.39	neutral	0.82	disease	0.8	disease	0.68	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.16	medium_impact	2.23	high_impact	0.31	0.8	NA	NA	0.39	N	0.93	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5247	5247	T	G	MI.14386	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	778	260	F	V	Ttt/Gtt	-5.89	0	0	probably_damaging	1	neutral	0.4	neutral	3.4	deleterious	-8.63	deleterious	-6.7	high_impact	4.01	0.58	damaging	0.06	damaging	4.24	23.90	deleterious	0.04	0.35	0.38	neutral	0.88	disease	0.81	disease	0.69	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.11	medium_impact	2.23	high_impact	0.33	0.8	NA	NA	0.4	N	0.96	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5248	5248	T	G	MI.14387	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	779	260	F	C	tTt/tGt	7.3	1	0	probably_damaging	1	neutral	0.12	neutral	3.37	deleterious	-10.66	deleterious	-7.66	high_impact	4.01	0.6	damaging	0.05	damaging	4.11	23.70	deleterious	0.02	0.35	0.89	disease	0.85	disease	0.82	disease	0.63	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.27	medium_impact	2.23	high_impact	0.19	0.8	NA	NA	0.61	P	0.99	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5248	5248	T	C	MI.14388	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	779	260	F	S	tTt/tCt	7.3	1	0	probably_damaging	1	neutral	0.36	neutral	3.38	deleterious	-9.25	deleterious	-7.66	high_impact	3.66	0.5	damaging	0.07	damaging	4.17	23.80	deleterious	0.02	0.35	0.68	disease	0.86	disease	0.78	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.07	medium_impact	1.94	medium_impact	0.20	0.8	NA	NA	0.58	P	0.95	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5248	5248	T	A	MI.14389	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	779	260	F	Y	tTt/tAt	7.3	1	0	probably_damaging	1	neutral	0.71	neutral	3.47	deleterious	-5.93	deleterious	-2.87	high_impact	4.01	0.6	damaging	0.06	damaging	4.23	23.90	deleterious	0.08	0.35	0.64	disease	0.8	disease	0.78	disease	0.69	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.42	medium_impact	2.23	high_impact	0.40	0.8	NA	NA	0.64	P	0.88	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9202	9202	A	C	MI.1439	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	676	226	T	P	Aca/Cca	-1.95	0	0	benign	0.35	deleterious	0.01	neutral	4.48	neutral	-2.03	deleterious	-3.82	neutral_impact	0.78	0.81	neutral	0.23	damaging	1.97	16.05	deleterious	0.34	0.65	NA	NA	0.25	neutral	0.67	disease	0.31	neutral	4	0.99	deleterious	0.33	neutral	-2	neutral	0.63	deleterious	-0.5	medium_impact	-0.84	medium_impact	-0.43	medium_impact	0.68	0.9	NA	NA	0.32	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5249	5249	T	A	MI.14390	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	780	260	F	L	ttT/ttA	5.68	1	0	probably_damaging	1	neutral	0.67	neutral	3.51	deleterious	-7.35	deleterious	-5.75	medium_impact	3.31	0.57	damaging	0.05	damaging	4.48	24.30	deleterious	0.03	0.35	0.38	neutral	0.81	disease	0.78	disease	0.69	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.38	medium_impact	1.64	medium_impact	0.54	0.8	NA	NA	0.55	P	0.91	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5249	5249	T	G	MI.14391	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	780	260	F	L	ttT/ttG	5.68	1	0	probably_damaging	1	neutral	0.67	neutral	3.51	deleterious	-7.35	deleterious	-5.75	medium_impact	3.31	0.57	damaging	0.05	damaging	4.26	23.90	deleterious	0.03	0.35	0.38	neutral	0.81	disease	0.78	disease	0.69	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.38	medium_impact	1.64	medium_impact	0.54	0.8	NA	NA	0.55	P	0.91	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5250	5250	T	G	MI.14392	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	781	261	L	V	Ttg/Gtg	-2.88	0	0	benign	0.42	neutral	0.56	neutral	4.62	neutral	0.45	neutral	-1.22	low_impact	1.7	0.93	neutral	0.75	neutral	2.30	18.19	deleterious	0.33	0.5	0.61	disease	0.52	disease	0.41	neutral	0.26	neutral	5	0.4	neutral	0.57	deleterious	-6	neutral	0.54	deleterious	-0.67	medium_impact	0.27	medium_impact	0.29	medium_impact	0.49	0.8	5.48	8.08	0.26	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5250	5250	T	A	MI.14393	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	781	261	L	M	Ttg/Atg	-2.88	0	0	benign	0.3	neutral	0.6	neutral	4.46	neutral	-1.59	neutral	0.05	neutral_impact	0.01	0.95	neutral	0.92	neutral	0.81	9.54	deleterious	0.33	0.5	0.61	disease	0.06	neutral	0.27	neutral	0.29	neutral	4	0.31	neutral	0.65	deleterious	-6	neutral	0.38	neutral	-0.46	medium_impact	0.31	medium_impact	-1.14	low_impact	0.43	0.8	5.48	8.08	0.38	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5251	5251	T	G	MI.14394	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	782	261	L	W	tTg/tGg	-1.72	0	0	probably_damaging	0.96	neutral	0.18	neutral	4.41	neutral	-1.01	deleterious	-3.9	medium_impact	2.64	0.84	neutral	0.43	neutral	3.78	23.40	deleterious	0.06	0.35	0.97	disease	0.74	disease	0.66	disease	0.75	disease	5	0.98	neutral	0.11	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	-0.16	medium_impact	1.08	medium_impact	0.21	0.8	5.48	8.08	0.31	N	0.84	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5251	5251	T	C	MI.14395	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	782	261	L	S	tTg/tCg	-1.72	0	0	benign	0.1	neutral	0.44	neutral	4.42	neutral	-2.49	deleterious	-3.31	low_impact	1.12	0.9	neutral	0.86	neutral	2.58	19.96	deleterious	0.03	0.35	0.86	disease	0.64	disease	0.5	neutral	0.47	neutral	1	0.49	neutral	0.67	deleterious	-6	neutral	0.35	neutral	0.08	medium_impact	0.15	medium_impact	-0.2	medium_impact	0.33	0.8	5.48	8.08	0.34	N	0.64	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5252	5252	G	C	MI.14396	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	783	261	L	F	ttG/ttC	1.05	0	0.01	possibly_damaging	0.82	neutral	0.67	neutral	4.5	neutral	0.33	neutral	-2.24	low_impact	0.91	0.9	neutral	0.56	neutral	3.54	23.10	deleterious	0.29	0.45	0.81	disease	0.62	disease	0.55	disease	0.65	disease	3	0.79	neutral	0.43	neutral	-3	neutral	0.73	deleterious	-1.4	low_impact	0.38	medium_impact	-0.38	medium_impact	0.56	0.8	5.48	8.08	0.28	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5252	5252	G	T	MI.14397	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	783	261	L	F	ttG/ttT	1.05	0	0.01	possibly_damaging	0.82	neutral	0.67	neutral	4.5	neutral	0.33	neutral	-2.24	low_impact	0.91	0.9	neutral	0.56	neutral	3.70	23.30	deleterious	0.29	0.45	0.81	disease	0.62	disease	0.55	disease	0.65	disease	3	0.79	neutral	0.43	neutral	-3	neutral	0.73	deleterious	-1.4	low_impact	0.38	medium_impact	-0.38	medium_impact	0.56	0.8	5.48	8.08	0.28	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5253	5253	C	T	MI.14398	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	784	262	P	S	Ccc/Tcc	-3.34	0	0	probably_damaging	1	neutral	0.45	neutral	4.88	neutral	3.74	deleterious	-7.66	medium_impact	2.59	0.64	neutral	0.06	damaging	3.99	23.60	deleterious	0.17	0.45	0.57	disease	0.8	disease	0.58	disease	0.65	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.16	medium_impact	1.04	medium_impact	0.29	0.8	NA	NA	0.31	N	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5253	5253	C	G	MI.14399	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	784	262	P	A	Ccc/Gcc	-3.34	0	0	probably_damaging	1	neutral	0.55	neutral	4.74	neutral	2.7	deleterious	-7.66	medium_impact	2.81	0.66	neutral	0.07	damaging	3.20	22.70	deleterious	0.11	0.4	0.39	neutral	0.68	disease	0.64	disease	0.65	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.26	medium_impact	1.22	medium_impact	0.68	0.85	NA	NA	0.29	N	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8594	8594	T	C	MI.144	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	68	23	I	T	aTc/aCc	2.67	0.98	0	benign	0.39	neutral	0.43	neutral	4.3	neutral	-1.27	neutral	-2.2	neutral_impact	0.67	0.9	neutral	0.42	neutral	0.34	6.05	deleterious	0.5	0.65	0.68	disease	0.38	neutral	0.37	neutral	0.63	disease	3	0.5	neutral	0.52	deleterious	-6	neutral	0.47	deleterious	-0.57	medium_impact	0.22	medium_impact	-0.52	medium_impact	0.57	0.9	19.03	10.37	0.45	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9202	9202	A	G	MI.1440	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	676	226	T	A	Aca/Gca	-1.95	0	0	benign	0.09	deleterious	0.01	neutral	4.59	neutral	-0.05	deleterious	-2.66	low_impact	1.73	0.87	neutral	0.29	neutral	1.63	14.02	neutral	0.56	0.65	NA	NA	0.12	neutral	0.64	disease	0.25	neutral	5	0.99	deleterious	0.46	neutral	-2	neutral	0.20	neutral	0.2	medium_impact	-0.84	medium_impact	0.39	medium_impact	0.61	0.9	NA	NA	0.4	N	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5253	5253	C	A	MI.14400	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	784	262	P	T	Ccc/Acc	-3.34	0	0	probably_damaging	1	neutral	0.42	neutral	4.64	neutral	0.08	deleterious	-7.66	medium_impact	3.21	0.66	neutral	0.03	damaging	3.80	23.40	deleterious	0.09	0.35	0.5	neutral	0.8	disease	0.64	disease	0.66	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.13	medium_impact	1.56	medium_impact	0.50	0.8	NA	NA	0.27	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5254	5254	C	A	MI.14401	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	785	262	P	H	cCc/cAc	4.06	0.98	0	probably_damaging	1	neutral	0.54	neutral	4.61	neutral	-2.23	deleterious	-8.62	high_impact	3.91	0.68	neutral	0.03	damaging	4.07	23.70	deleterious	0.06	0.35	0.87	disease	0.85	disease	0.74	disease	0.62	disease	2	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.25	medium_impact	2.15	high_impact	0.42	0.8	NA	NA	0.55	P	0.71	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5254	5254	C	T	MI.14402	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	785	262	P	L	cCc/cTc	4.06	0.98	0	probably_damaging	1	neutral	0.68	neutral	4.67	neutral	-1.14	deleterious	-9.57	medium_impact	2.81	0.66	neutral	0.03	damaging	4.52	24.30	deleterious	0.09	0.35	0.52	disease	0.86	disease	0.63	disease	0.68	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.39	medium_impact	1.22	medium_impact	0.60	0.8	NA	NA	0.44	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5254	5254	C	G	MI.14403	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	785	262	P	R	cCc/cGc	4.06	0.98	0	probably_damaging	1	neutral	0.37	neutral	4.62	neutral	-1.19	deleterious	-8.62	high_impact	3.91	0.64	neutral	0.04	damaging	3.68	23.30	deleterious	0.04	0.35	0.83	disease	0.89	disease	0.73	disease	0.67	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.08	medium_impact	2.15	high_impact	0.56	0.8	NA	NA	0.6	P	0.56	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5256	5256	A	G	MI.14404	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	787	263	K	E	Aaa/Gaa	-11.21	0	0	probably_damaging	1	neutral	0.92	neutral	4.12	neutral	-2.93	deleterious	-3.83	high_impact	4.01	0.74	neutral	0.07	damaging	4.11	23.70	deleterious	0.06	0.35	0.84	disease	0.83	disease	0.78	disease	0.68	disease	4	1	deleterious	0.46	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.8	medium_impact	2.23	high_impact	0.48	0.8	NA	NA	0.29	N	0.91	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5256	5256	A	C	MI.14405	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	787	263	K	Q	Aaa/Caa	-11.21	0	0	probably_damaging	1	neutral	0.68	neutral	3.84	deleterious	-6.11	deleterious	-3.83	high_impact	3.66	0.74	neutral	0.07	damaging	3.49	23.10	deleterious	0.08	0.35	0.4	neutral	0.8	disease	0.75	disease	0.68	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	0.39	medium_impact	1.94	medium_impact	0.48	0.8	NA	NA	0.29	N	0.88	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5257	5257	A	C	MI.14406	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	788	263	K	T	aAa/aCa	8.45	1	0	probably_damaging	1	neutral	0.75	neutral	3.83	deleterious	-6.73	deleterious	-5.74	high_impact	4.01	0.73	neutral	0.07	damaging	3.72	23.30	deleterious	0.05	0.35	0.52	disease	0.8	disease	0.79	disease	0.68	disease	4	1	deleterious	0.38	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.47	medium_impact	2.23	high_impact	0.25	0.8	NA	NA	0.59	P	0.81	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5257	5257	A	T	MI.14407	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	788	263	K	M	aAa/aTa	8.45	1	0	probably_damaging	1	neutral	0.3	neutral	3.8	deleterious	-8.57	deleterious	-5.74	high_impact	4.01	0.73	neutral	0.05	damaging	4.08	23.70	deleterious	0.04	0.35	0.68	disease	0.8	disease	0.79	disease	0.68	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0	medium_impact	2.23	high_impact	0.26	0.8	NA	NA	0.63	P	0.45	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5258	5258	A	T	MI.14408	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	789	263	K	N	aaA/aaT	8.45	1	0	probably_damaging	1	neutral	0.64	neutral	3.84	deleterious	-6.37	deleterious	-4.78	high_impact	4.01	0.71	neutral	0.05	damaging	4.03	23.60	deleterious	0.07	0.35	0.84	disease	0.82	disease	0.79	disease	0.66	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.35	medium_impact	2.23	high_impact	0.38	0.8	NA	NA	0.64	P	0.69	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5258	5258	A	C	MI.14409	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	789	263	K	N	aaA/aaC	8.45	1	0	probably_damaging	1	neutral	0.64	neutral	3.84	deleterious	-6.37	deleterious	-4.78	high_impact	4.01	0.71	neutral	0.05	damaging	3.99	23.60	deleterious	0.07	0.35	0.84	disease	0.82	disease	0.79	disease	0.66	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.35	medium_impact	2.23	high_impact	0.38	0.8	NA	NA	0.63	P	0.69	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9202	9202	A	T	MI.1441	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	676	226	T	S	Aca/Tca	-1.95	0	0	benign	0.01	neutral	0.32	neutral	4.56	neutral	-0.37	neutral	-2.25	low_impact	1	0.95	neutral	0.75	neutral	0.09	3.52	deleterious	0.57	0.65	NA	NA	0.06	neutral	0.47	neutral	0.16	neutral	7	0.67	neutral	0.66	deleterious	-6	neutral	0.08	neutral	1.14	medium_impact	0.11	medium_impact	-0.24	medium_impact	0.80	0.9	NA	NA	0.45	N	0.02	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5259	5259	T	G	MI.14410	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	790	264	W	G	Tgg/Ggg	2.67	1	0	probably_damaging	0.94	neutral	0.23	neutral	4.59	neutral	-2.46	deleterious	-12.41	high_impact	3.86	0.91	neutral	0.12	damaging	4.04	23.70	deleterious	0.04	0.35	0.86	disease	0.87	disease	0.75	disease	0.63	disease	3	0.96	neutral	0.15	neutral	2	deleterious	0.81	deleterious	-1.89	low_impact	-0.08	medium_impact	2.11	high_impact	0.16	0.8	NA	NA	0.59	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5259	5259	T	C	MI.14411	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	790	264	W	R	Tgg/Cgg	2.67	1	0	probably_damaging	0.99	neutral	0.2	neutral	4.6	neutral	-2.35	deleterious	-13.37	high_impact	3.86	0.79	neutral	0.09	damaging	3.73	23.30	deleterious	0.03	0.35	0.59	disease	0.93	disease	0.79	disease	0.74	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-2.62	low_impact	-0.13	medium_impact	2.11	high_impact	0.21	0.8	NA	NA	0.56	P	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5260	5260	G	C	MI.14412	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	791	264	W	S	tGg/tCg	5.68	1	0	probably_damaging	0.97	neutral	0.29	neutral	4.62	neutral	-1.45	deleterious	-13.36	high_impact	3.86	0.81	neutral	0.12	damaging	4.12	23.80	deleterious	0.04	0.35	0.72	disease	0.93	disease	0.73	disease	0.72	disease	4	0.98	neutral	0.16	neutral	2	deleterious	0.86	deleterious	-2.18	low_impact	-0.01	medium_impact	2.11	high_impact	0.17	0.8	NA	NA	0.58	P	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5260	5260	G	T	MI.14413	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	791	264	W	L	tGg/tTg	5.68	1	0	possibly_damaging	0.77	neutral	1	neutral	4.77	neutral	1.36	deleterious	-12.41	low_impact	1.6	0.79	neutral	0.08	damaging	4.34	24.00	deleterious	0.09	0.35	0.59	disease	0.85	disease	0.67	disease	0.39	neutral	2	0.77	neutral	0.62	deleterious	-3	neutral	0.73	deleterious	-1.28	low_impact	1.87	high_impact	0.2	medium_impact	0.15	0.8	NA	NA	0.42	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5261	5261	G	C	MI.14414	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	792	264	W	C	tgG/tgC	7.07	1	0.02	probably_damaging	0.99	neutral	0.12	neutral	4.58	deleterious	-3.02	deleterious	-12.41	high_impact	3.52	0.77	neutral	0.08	damaging	4.10	23.70	deleterious	0.04	0.35	0.74	disease	0.91	disease	0.77	disease	0.7	disease	4	0.99	deleterious	0.07	neutral	2	deleterious	0.84	deleterious	-2.62	low_impact	-0.27	medium_impact	1.82	medium_impact	0.26	0.8	NA	NA	0.56	P	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5261	5261	G	T	MI.14415	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	792	264	W	C	tgG/tgT	7.07	1	0.02	probably_damaging	0.99	neutral	0.12	neutral	4.58	deleterious	-3.02	deleterious	-12.41	high_impact	3.52	0.77	neutral	0.08	damaging	4.26	23.90	deleterious	0.04	0.35	0.74	disease	0.91	disease	0.77	disease	0.7	disease	4	0.99	deleterious	0.07	neutral	2	deleterious	0.84	deleterious	-2.62	low_impact	-0.27	medium_impact	1.82	medium_impact	0.26	0.8	NA	NA	0.57	P	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5262	5262	G	T	MI.14416	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	793	265	A	S	Gcc/Tcc	1.28	0.5	0	benign	0.06	neutral	0.3	neutral	4.62	neutral	-1.6	neutral	-0.58	neutral_impact	0.2	0.84	neutral	0.64	neutral	1.94	15.85	deleterious	0.23	0.45	0.54	disease	0.44	neutral	0.43	neutral	0.51	disease	0	0.67	neutral	0.62	deleterious	-6	neutral	0.23	neutral	0.3	medium_impact	0	medium_impact	-0.98	medium_impact	0.57	0.8	2.59	8.19	0.35	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5262	5262	G	C	MI.14417	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	793	265	A	P	Gcc/Ccc	1.28	0.5	0	benign	0.3	neutral	0.08	neutral	4.57	deleterious	-3.71	neutral	-1.62	neutral_impact	0.55	0.74	neutral	0.38	neutral	2.20	17.52	deleterious	0.04	0.35	0.92	disease	0.82	disease	0.6	disease	0.69	disease	4	0.91	neutral	0.39	neutral	-6	neutral	0.55	deleterious	-0.46	medium_impact	-0.38	medium_impact	-0.68	medium_impact	0.66	0.8	2.59	8.19	0.29	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5262	5262	G	A	MI.14418	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	793	265	A	T	Gcc/Acc	1.28	0.5	0	benign	0.01	neutral	0.2	neutral	4.63	neutral	-1.38	neutral	-0.36	neutral_impact	-0.18	0.99	neutral	0.88	neutral	2.33	18.39	deleterious	0.17	0.45	0.73	disease	0.4	neutral	0.45	neutral	0.65	disease	3	0.8	neutral	0.6	deleterious	-6	neutral	0.19	neutral	1.03	medium_impact	-0.13	medium_impact	-1.3	low_impact	0.76	0.85	2.59	8.19	0.44	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5263	5263	C	T	MI.14419	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	794	265	A	V	gCc/gTc	-1.26	0	0.04	benign	0	neutral	0.25	neutral	4.66	neutral	-0.85	neutral	1.63	neutral_impact	-0.32	0.99	neutral	0.96	neutral	1.47	13.13	neutral	0.16	0.45	0.65	disease	0.46	neutral	0.41	neutral	0.62	disease	2	0.75	neutral	0.63	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	-0.06	medium_impact	-1.41	low_impact	0.73	0.85	2.59	8.19	0.35	N	0.00	polymorphism	1	0.01	rs41320049	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9203	9203	C	A	MI.1442	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	677	226	T	K	aCa/aAa	0.59	0	0	benign	0.14	deleterious	0.01	neutral	4.52	neutral	-0.86	deleterious	-3.85	medium_impact	2.62	0.88	neutral	0.26	damaging	2.83	21.50	deleterious	0.37	0.65	NA	NA	0.29	neutral	0.67	disease	0.32	neutral	4	0.99	deleterious	0.44	neutral	1	deleterious	0.33	neutral	-0.01	medium_impact	-0.84	medium_impact	1.15	medium_impact	0.63	0.9	NA	NA	0.39	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5263	5263	C	G	MI.14420	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	794	265	A	G	gCc/gGc	-1.26	0	0.04	benign	0.16	neutral	0.12	neutral	4.58	neutral	-2.25	neutral	-2.36	neutral_impact	0.06	0.88	neutral	0.59	neutral	2.14	17.13	deleterious	0.19	0.45	0.54	disease	0.44	neutral	0.43	neutral	0.51	disease	0	0.86	neutral	0.48	deleterious	-6	neutral	0.24	neutral	-0.14	medium_impact	-0.27	medium_impact	-1.09	low_impact	0.66	0.8	2.59	8.19	0.44	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5263	5263	C	A	MI.14421	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	794	265	A	D	gCc/gAc	-1.26	0	0.04	benign	0.3	deleterious	0.04	neutral	4.56	deleterious	-4.22	neutral	-2.42	low_impact	1.1	0.85	neutral	0.46	neutral	2.74	21.00	deleterious	0.02	0.35	0.94	disease	0.73	disease	0.59	disease	0.73	disease	5	0.95	neutral	0.37	neutral	-2	neutral	0.52	deleterious	-0.46	medium_impact	-0.56	medium_impact	-0.22	medium_impact	0.39	0.8	2.59	8.19	0.31	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5265	5265	A	C	MI.14422	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	796	266	I	L	Att/Ctt	-6.35	0	0	benign	0.08	neutral	0.91	neutral	4.57	neutral	-0.47	neutral	-1.79	medium_impact	2.48	0.85	neutral	0.47	neutral	2.04	16.45	deleterious	0.16	0.45	0.46	neutral	0.77	disease	0.55	disease	0.64	disease	3	0.03	neutral	0.92	deleterious	-3	neutral	0.34	neutral	0.17	medium_impact	0.77	medium_impact	0.94	medium_impact	0.55	0.8	0.86	7.31	0.18	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5265	5265	A	T	MI.14423	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	796	266	I	F	Att/Ttt	-6.35	0	0	possibly_damaging	0.57	neutral	0.38	neutral	4.31	neutral	-2.81	deleterious	-3.64	medium_impact	3.42	0.93	neutral	0.47	neutral	3.86	23.50	deleterious	0.05	0.35	0.79	disease	0.86	disease	0.63	disease	0.67	disease	3	0.64	neutral	0.41	neutral	0	NA	0.76	deleterious	-0.91	medium_impact	0.09	medium_impact	1.73	medium_impact	0.54	0.8	0.86	7.31	0.41	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5265	5265	A	G	MI.14424	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	796	266	I	V	Att/Gtt	-6.35	0	0	benign	0.01	neutral	0.35	neutral	4.59	neutral	-0.24	neutral	-0.81	low_impact	1.45	0.88	neutral	0.7	neutral	1.17	11.61	neutral	0.35	0.5	0.54	disease	0.53	disease	0.5	neutral	0.24	neutral	5	0.64	neutral	0.67	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	0.06	medium_impact	0.08	medium_impact	0.40	0.8	0.86	7.31	0.31	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5266	5266	T	C	MI.14425	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	797	266	I	T	aTt/aCt	4.75	0.99	0	benign	0.01	neutral	0.18	neutral	4.34	deleterious	-3.32	deleterious	-4.08	medium_impact	2.12	0.84	neutral	0.62	neutral	0.70	8.86	deleterious	0.03	0.35	0.66	disease	0.83	disease	0.56	disease	0.29	neutral	4	0.82	neutral	0.59	deleterious	-3	neutral	0.30	neutral	1.03	medium_impact	-0.16	medium_impact	0.64	medium_impact	0.28	0.8	0.86	7.31	0.51	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5266	5266	T	A	MI.14426	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	797	266	I	N	aTt/aAt	4.75	0.99	0	possibly_damaging	0.57	neutral	0.27	neutral	4.28	deleterious	-5.33	deleterious	-6.19	high_impact	3.77	0.87	neutral	0.47	neutral	4.41	24.10	deleterious	0.03	0.35	0.82	disease	0.92	disease	0.63	disease	0.66	disease	3	0.73	neutral	0.35	neutral	1	deleterious	0.77	deleterious	-0.91	medium_impact	-0.03	medium_impact	2.03	high_impact	0.36	0.8	0.86	7.31	0.65	P	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5266	5266	T	G	MI.14427	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	797	266	I	S	aTt/aGt	4.75	0.99	0	benign	0.29	neutral	0.32	neutral	4.35	deleterious	-3.82	deleterious	-5.24	medium_impact	2.44	0.87	neutral	0.58	neutral	4.03	23.60	deleterious	0.02	0.35	0.46	neutral	0.91	disease	0.6	disease	0.69	disease	4	0.61	neutral	0.52	deleterious	-3	neutral	0.56	deleterious	-0.44	medium_impact	0.03	medium_impact	0.91	medium_impact	0.40	0.8	0.86	7.31	0.57	P	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5267	5267	T	A	MI.14428	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	798	266	I	M	atT/atA	2.9	0.99	0	possibly_damaging	0.75	neutral	0.28	neutral	4.31	deleterious	-3.03	deleterious	-2.67	medium_impact	2.57	0.94	neutral	0.57	neutral	3.62	23.20	deleterious	0.08	0.35	0.7	disease	0.76	disease	0.55	disease	0.64	disease	3	0.81	neutral	0.27	neutral	0	NA	0.71	deleterious	-1.23	low_impact	-0.02	medium_impact	1.02	medium_impact	0.49	0.8	0.86	7.31	0.57	P	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5267	5267	T	G	MI.14429	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	798	266	I	M	atT/atG	2.9	0.99	0	possibly_damaging	0.75	neutral	0.28	neutral	4.31	deleterious	-3.03	deleterious	-2.67	medium_impact	2.57	0.94	neutral	0.57	neutral	3.29	22.80	deleterious	0.08	0.35	0.7	disease	0.76	disease	0.55	disease	0.64	disease	3	0.81	neutral	0.27	neutral	0	NA	0.71	deleterious	-1.23	low_impact	-0.02	medium_impact	1.02	medium_impact	0.49	0.8	0.86	7.31	0.56	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9203	9203	C	T	MI.1443	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	677	226	T	M	aCa/aTa	0.59	0	0	possibly_damaging	0.78	deleterious	0	neutral	4.47	neutral	-2.16	deleterious	-3.41	medium_impact	2.27	0.89	neutral	0.26	damaging	4.03	23.60	deleterious	0.38	0.65	NA	NA	0.21	neutral	0.69	disease	0.35	neutral	3	1	deleterious	0.11	neutral	4	deleterious	0.77	deleterious	-1.28	low_impact	-1.4	low_impact	0.85	medium_impact	0.76	0.9	NA	NA	0.44	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5268	5268	A	G	MI.14430	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	799	267	I	V	Atc/Gtc	-7.05	0	0	benign	0.36	neutral	0.38	neutral	4.34	neutral	-2.77	neutral	-0.87	medium_impact	2.23	0.93	neutral	0.75	neutral	3.13	22.60	deleterious	0.48	0.55	0.55	disease	0.47	neutral	0.48	neutral	0.59	disease	2	0.55	neutral	0.51	deleterious	-3	neutral	0.49	deleterious	-0.57	medium_impact	0.09	medium_impact	0.73	medium_impact	0.44	0.8	1.15	8.18	0.36	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5268	5268	A	C	MI.14431	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	799	267	I	L	Atc/Ctc	-7.05	0	0	benign	0.02	neutral	1	neutral	5.36	neutral	1.96	neutral	-1.59	neutral_impact	0.45	0.89	neutral	0.9	neutral	2.26	17.90	deleterious	0.25	0.45	0.44	neutral	0.23	neutral	0.23	neutral	0.46	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	1.87	high_impact	-0.77	medium_impact	0.50	0.8	1.15	8.18	0.37	N	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5268	5268	A	T	MI.14432	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	799	267	I	F	Atc/Ttc	-7.05	0	0	possibly_damaging	0.78	neutral	0.47	neutral	4.45	neutral	-1.26	deleterious	-3.58	medium_impact	2.15	0.9	neutral	0.47	neutral	3.87	23.50	deleterious	0.08	0.35	0.62	disease	0.82	disease	0.58	disease	0.67	disease	3	0.77	neutral	0.35	neutral	0	NA	0.74	deleterious	-1.3	low_impact	0.18	medium_impact	0.67	medium_impact	0.48	0.8	1.15	8.18	0.36	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5269	5269	T	G	MI.14433	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	800	267	I	S	aTc/aGc	0.82	0.27	0	possibly_damaging	0.87	neutral	0.34	neutral	4.29	deleterious	-5.8	deleterious	-5.42	medium_impact	2.96	0.88	neutral	0.48	neutral	4.34	24.00	deleterious	0.02	0.35	0.89	disease	0.87	disease	0.58	disease	0.69	disease	4	0.88	neutral	0.24	neutral	0	NA	0.83	deleterious	-1.55	low_impact	0.05	medium_impact	1.35	medium_impact	0.18	0.8	1.15	8.18	0.42	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5269	5269	T	C	MI.14434	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	800	267	I	T	aTc/aCc	0.82	0.27	0	possibly_damaging	0.74	neutral	0.25	neutral	4.3	deleterious	-4.86	deleterious	-4.5	medium_impact	2.54	0.92	neutral	0.57	neutral	3.48	23.10	deleterious	0.02	0.35	0.85	disease	0.76	disease	0.53	disease	0.6	disease	2	0.82	neutral	0.26	neutral	0	NA	0.78	deleterious	-1.21	low_impact	-0.06	medium_impact	0.99	medium_impact	0.23	0.8	1.15	8.18	0.45	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5269	5269	T	A	MI.14435	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	800	267	I	N	aTc/aAc	0.82	0.27	0	probably_damaging	0.96	neutral	0.28	neutral	4.29	deleterious	-6.92	deleterious	-6.38	high_impact	3.51	0.89	neutral	0.44	neutral	4.46	24.20	deleterious	0.03	0.35	0.95	disease	0.9	disease	0.59	disease	0.73	disease	5	0.96	neutral	0.16	neutral	2	deleterious	0.86	deleterious	-2.06	low_impact	-0.02	medium_impact	1.81	medium_impact	0.15	0.8	1.15	8.18	0.45	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5270	5270	C	G	MI.14436	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	801	267	I	M	atC/atG	4.29	0.7	0	benign	0.12	neutral	0.25	neutral	4.35	neutral	-2.53	neutral	-2.4	medium_impact	2.19	0.92	neutral	0.86	neutral	3.38	23.00	deleterious	0.09	0.4	0.8	disease	0.61	disease	0.48	neutral	0.5	disease	0	0.71	neutral	0.57	deleterious	-3	neutral	0.41	neutral	-0.01	medium_impact	-0.06	medium_impact	0.7	medium_impact	0.46	0.8	1.15	8.18	0.42	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5270	5270	C	A	MI.14437	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	801	267	I	M	atC/atA	4.29	0.7	0	benign	0.12	neutral	0.25	neutral	4.35	neutral	-2.53	neutral	-2.4	medium_impact	2.19	0.92	neutral	0.86	neutral	3.85	23.40	deleterious	0.09	0.4	0.8	disease	0.61	disease	0.48	neutral	0.5	disease	0	0.71	neutral	0.57	deleterious	-3	neutral	0.41	neutral	-0.01	medium_impact	-0.06	medium_impact	0.7	medium_impact	0.46	0.8	1.15	8.18	0.43	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5271	5271	G	C	MI.14438	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	802	268	E	Q	Gaa/Caa	-8.66	0	0	benign	0.01	neutral	0.34	neutral	4.54	neutral	-0.37	neutral	1.74	neutral_impact	-1.76	0.9	neutral	0.94	neutral	0.47	7.22	deleterious	0.24	0.45	0.36	neutral	0.05	neutral	0.12	neutral	0.22	neutral	6	0.65	neutral	0.67	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.05	medium_impact	-2.63	low_impact	0.63	0.8	6.92	8.54	0.51	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5271	5271	G	A	MI.14439	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	802	268	E	K	Gaa/Aaa	-8.66	0	0	benign	0.14	neutral	0.32	neutral	4.53	neutral	-0.8	neutral	-0.75	neutral_impact	-0.24	0.86	neutral	0.72	neutral	1.94	15.81	deleterious	0.07	0.35	0.49	neutral	0.7	disease	0.29	neutral	0.19	neutral	6	0.63	neutral	0.59	deleterious	-6	neutral	0.38	neutral	-0.08	medium_impact	0.03	medium_impact	-1.35	low_impact	0.70	0.85	6.92	8.54	0.31	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8366	8366	A	C	MI.1444	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	1	1	M	L	Atg/Ctg	-9.59	0	0	possibly_damaging	0.66	deleterious	0	deleterious	-2.11	deleterious	-10.1	deleterious	-2.98	NA	NA	0.89	neutral	0.07	damaging	2.74	21.10	deleterious	0.22690910	0.85	0.36	neutral	0.11	neutral	0.71	disease	0.19	neutral	6	1	deleterious	0.17	neutral	3	deleterious	0.42	neutral	NA	NA	NA	NA	NA	NA	0.35	0.85	20.59	8.49	0.44	N	0.67	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5272	5272	A	T	MI.14440	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	803	268	E	V	gAa/gTa	0.36	0.04	0	benign	0.14	neutral	0.52	neutral	4.54	neutral	-1.5	deleterious	-3.74	neutral_impact	0.64	0.88	neutral	0.67	neutral	4.14	23.80	deleterious	0.09	0.35	0.73	disease	0.69	disease	0.49	neutral	0.48	neutral	0	0.39	neutral	0.69	deleterious	-6	neutral	0.41	neutral	-0.08	medium_impact	0.23	medium_impact	-0.61	medium_impact	0.28	0.8	6.92	8.54	0.29	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5272	5272	A	G	MI.14441	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	803	268	E	G	gAa/gGa	0.36	0.04	0	benign	0.01	neutral	0.34	neutral	4.52	neutral	-1.41	deleterious	-3.34	low_impact	1.38	0.9	neutral	0.56	neutral	2.44	19.07	deleterious	0.12	0.4	0.46	neutral	0.55	disease	0.51	disease	0.52	disease	0	0.65	neutral	0.67	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	0.05	medium_impact	0.02	medium_impact	0.27	0.8	6.92	8.54	0.44	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5272	5272	A	C	MI.14442	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	803	268	E	A	gAa/gCa	0.36	0.04	0	benign	0.14	neutral	0.52	neutral	4.59	neutral	-0.55	deleterious	-2.8	low_impact	1.04	0.89	neutral	0.72	neutral	2.14	17.10	deleterious	0.11	0.4	0.48	neutral	0.46	neutral	0.48	neutral	0.4	neutral	2	0.39	neutral	0.69	deleterious	-6	neutral	0.34	neutral	-0.08	medium_impact	0.23	medium_impact	-0.27	medium_impact	0.35	0.8	6.92	8.54	0.34	N	0.32	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5273	5273	A	C	MI.14443	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	804	268	E	D	gaA/gaC	4.52	0.98	0	benign	0.18	neutral	0.22	neutral	4.5	neutral	-1.7	neutral	-1.27	neutral_impact	0.7	0.86	neutral	0.77	neutral	2.16	17.24	deleterious	0.3	0.45	0.59	disease	0.51	disease	0.32	neutral	0.36	neutral	3	0.74	neutral	0.52	deleterious	-6	neutral	0.44	deleterious	-0.19	medium_impact	-0.1	medium_impact	-0.56	medium_impact	0.58	0.8	6.92	8.54	0.57	P	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5273	5273	A	T	MI.14444	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	804	268	E	D	gaA/gaT	4.52	0.98	0	benign	0.18	neutral	0.22	neutral	4.5	neutral	-1.7	neutral	-1.27	neutral_impact	0.7	0.86	neutral	0.77	neutral	2.28	18.02	deleterious	0.3	0.45	0.59	disease	0.51	disease	0.32	neutral	0.36	neutral	3	0.74	neutral	0.52	deleterious	-6	neutral	0.44	deleterious	-0.19	medium_impact	-0.1	medium_impact	-0.56	medium_impact	0.58	0.8	6.92	8.54	0.59	P	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5274	5274	G	C	MI.14445	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	805	269	E	Q	Gaa/Caa	0.36	0.97	0	probably_damaging	1	neutral	0.3	neutral	4.14	neutral	-1.05	deleterious	-2.87	medium_impact	2.08	0.87	neutral	0.14	damaging	3.44	23.00	deleterious	0.19	0.45	0.82	disease	0.81	disease	0.62	disease	0.64	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0	medium_impact	0.61	medium_impact	0.48	0.8	NA	NA	0.39	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5274	5274	G	A	MI.14446	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	805	269	E	K	Gaa/Aaa	0.36	0.97	0	probably_damaging	1	neutral	0.31	neutral	4.15	neutral	-0.72	deleterious	-3.83	medium_impact	2.27	0.88	neutral	0.12	damaging	4.56	24.40	deleterious	0.08	0.35	0.8	disease	0.91	disease	0.6	disease	0.64	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	0.02	medium_impact	0.77	medium_impact	0.53	0.8	NA	NA	0.43	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5275	5275	A	C	MI.14447	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	806	269	E	A	gAa/gCa	4.98	1	0	probably_damaging	1	neutral	0.52	neutral	4.45	neutral	1.92	deleterious	-5.74	medium_impact	2.3	0.88	neutral	0.15	damaging	3.65	23.20	deleterious	0.13	0.4	0.41	neutral	0.77	disease	0.65	disease	0.66	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.23	medium_impact	0.79	medium_impact	0.29	0.8	NA	NA	0.45	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5275	5275	A	G	MI.14448	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	806	269	E	G	gAa/gGa	4.98	1	0	probably_damaging	1	neutral	0.35	neutral	4.2	neutral	0.25	deleterious	-6.7	medium_impact	2.52	0.93	neutral	0.18	damaging	4.18	23.80	deleterious	0.14	0.4	0.83	disease	0.82	disease	0.62	disease	0.63	disease	3	1	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.06	medium_impact	0.98	medium_impact	0.19	0.8	NA	NA	0.54	N	0.46	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5275	5275	A	T	MI.14449	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	806	269	E	V	gAa/gTa	4.98	1	0	probably_damaging	1	neutral	0.51	neutral	4.11	neutral	-1.69	deleterious	-6.7	medium_impact	2.3	0.84	neutral	0.13	damaging	4.11	23.70	deleterious	0.08	0.35	0.37	neutral	0.9	disease	0.67	disease	0.7	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.22	medium_impact	0.79	medium_impact	0.29	0.8	NA	NA	0.43	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8366	8366	A	T	MI.1445	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	1	1	M	L	Atg/Ttg	-9.59	0	0	possibly_damaging	0.66	deleterious	0	deleterious	-2.11	deleterious	-10.1	deleterious	-2.98	NA	NA	0.89	neutral	0.07	damaging	2.75	21.10	deleterious	0.22690910	0.85	0.36	neutral	0.11	neutral	0.71	disease	0.19	neutral	6	1	deleterious	0.17	neutral	3	deleterious	0.42	neutral	NA	NA	NA	NA	NA	NA	0.35	0.85	20.59	8.49	0.45	N	0.67	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5276	5276	A	C	MI.14450	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	807	269	E	D	gaA/gaC	6.37	1	0	probably_damaging	1	neutral	0.21	neutral	4.12	neutral	-1.56	deleterious	-2.87	medium_impact	2.34	0.9	neutral	0.19	damaging	3.72	23.30	deleterious	0.23	0.45	0.88	disease	0.76	disease	0.49	neutral	0.53	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.11	medium_impact	0.83	medium_impact	0.56	0.8	NA	NA	0.63	P	0.85	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5276	5276	A	T	MI.14451	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	807	269	E	D	gaA/gaT	6.37	1	0	probably_damaging	1	neutral	0.21	neutral	4.12	neutral	-1.56	deleterious	-2.87	medium_impact	2.34	0.9	neutral	0.19	damaging	3.83	23.40	deleterious	0.23	0.45	0.88	disease	0.76	disease	0.49	neutral	0.53	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.11	medium_impact	0.83	medium_impact	0.56	0.8	NA	NA	0.64	P	0.85	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5277	5277	T	A	MI.14452	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	808	270	F	I	Ttc/Atc	0.13	0	0	benign	0.01	neutral	0.38	neutral	4.22	neutral	-0.77	neutral	1.47	neutral_impact	-0.6	0.9	neutral	0.94	neutral	2.77	21.20	deleterious	0.16	0.45	0.39	neutral	0.41	neutral	0.2	neutral	0.44	neutral	1	0.61	neutral	0.69	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.09	medium_impact	-1.65	low_impact	0.57	0.8	0.29	8.23	0.4	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5277	5277	T	G	MI.14453	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	808	270	F	V	Ttc/Gtc	0.13	0	0	benign	0.04	neutral	0.39	neutral	4.26	neutral	-0.03	neutral	0.71	neutral_impact	-0.3	0.93	neutral	0.75	neutral	2.40	18.85	deleterious	0.09	0.35	0.37	neutral	0.55	disease	0.36	neutral	0.43	neutral	1	0.58	neutral	0.68	deleterious	-6	neutral	0.22	neutral	0.47	medium_impact	0.1	medium_impact	-1.4	low_impact	0.40	0.8	0.29	8.23	0.32	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5277	5277	T	C	MI.14454	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	808	270	F	L	Ttc/Ctc	0.13	0	0	benign	0	neutral	1	neutral	4.41	neutral	0.54	neutral	2.96	neutral_impact	-2.67	0.91	neutral	0.95	neutral	-0.37	0.45	neutral	0.21	0.45	0.57	disease	0.12	neutral	0.15	neutral	0.33	neutral	3	0	neutral	1	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	1.87	high_impact	-3.39	low_impact	0.75	0.85	0.29	8.23	0.28	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5278	5278	T	A	MI.14455	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	809	270	F	Y	tTc/tAc	-2.19	0	0	benign	0.41	neutral	0.56	neutral	4.15	neutral	-2.05	neutral	-1.04	neutral_impact	-0.14	0.91	neutral	0.57	neutral	2.79	21.30	deleterious	0.14	0.4	0.83	disease	0.43	neutral	0.48	neutral	0.65	disease	3	0.4	neutral	0.58	deleterious	-6	neutral	0.61	deleterious	-0.65	medium_impact	0.27	medium_impact	-1.26	low_impact	0.70	0.85	0.29	8.23	0.33	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5278	5278	T	C	MI.14456	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	809	270	F	S	tTc/tCc	-2.19	0	0	benign	0.41	neutral	0.44	neutral	4.19	neutral	-1.42	neutral	-1.95	neutral_impact	-0.55	0.82	neutral	0.54	neutral	2.71	20.90	deleterious	0.04	0.35	0.78	disease	0.53	disease	0.52	disease	0.53	disease	1	0.5	neutral	0.52	deleterious	-6	neutral	0.62	deleterious	-0.65	medium_impact	0.15	medium_impact	-1.61	low_impact	0.25	0.8	0.29	8.23	0.27	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5278	5278	T	G	MI.14457	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	809	270	F	C	tTc/tGc	-2.19	0	0	possibly_damaging	0.85	neutral	0.07	neutral	4.13	neutral	-2.97	neutral	-1.24	neutral_impact	0.2	0.84	neutral	0.43	neutral	4.07	23.70	deleterious	0.04	0.35	0.89	disease	0.6	disease	0.5	neutral	0.54	disease	1	0.96	neutral	0.11	neutral	-3	neutral	0.75	deleterious	-1.49	low_impact	-0.42	medium_impact	-0.98	medium_impact	0.18	0.8	0.29	8.23	0.35	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5279	5279	C	A	MI.14458	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	810	270	F	L	ttC/ttA	7.3	0.94	0	benign	0	neutral	1	neutral	4.41	neutral	0.54	neutral	2.96	neutral_impact	-2.67	0.91	neutral	0.95	neutral	0.03	2.86	deleterious	0.21	0.45	0.57	disease	0.12	neutral	0.15	neutral	0.33	neutral	3	0	neutral	1	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	1.87	high_impact	-3.39	low_impact	0.75	0.85	0.29	8.23	0.41	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5279	5279	C	G	MI.14459	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	810	270	F	L	ttC/ttG	7.3	0.94	0	benign	0	neutral	1	neutral	4.41	neutral	0.54	neutral	2.96	neutral_impact	-2.67	0.91	neutral	0.95	neutral	-0.26	0.82	neutral	0.21	0.45	0.57	disease	0.12	neutral	0.15	neutral	0.33	neutral	3	0	neutral	1	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	1.87	high_impact	-3.39	low_impact	0.75	0.85	0.29	8.23	0.41	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8366	8366	A	G	MI.1446	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	1	1	M	V	Atg/Gtg	-9.59	0	0	possibly_damaging	0.75	deleterious	0	deleterious	-2.12	deleterious	-11.65	deleterious	-3.97	NA	NA	0.84	neutral	0.09	damaging	2.10	16.83	deleterious	0.29828471	0.85	0.54	disease	0.09	neutral	0.73	disease	0.19	neutral	6	1	deleterious	0.13	neutral	3	deleterious	0.47	deleterious	NA	NA	NA	NA	NA	NA	0.38	0.85	20.59	8.49	0.36	N	0.81	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5280	5280	A	T	MI.14460	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	811	271	T	S	Aca/Tca	-3.34	0	0	possibly_damaging	0.56	neutral	0.44	neutral	4.15	neutral	-0.88	deleterious	-3.44	medium_impact	2.15	0.87	neutral	0.66	neutral	1.39	12.76	neutral	0.34	0.5	0.68	disease	0.51	disease	0.26	neutral	0.23	neutral	5	0.59	neutral	0.44	neutral	0	NA	0.54	deleterious	-0.89	medium_impact	0.15	medium_impact	0.67	medium_impact	0.53	0.8	0.58	8.4	0.36	N	0.32	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5280	5280	A	G	MI.14461	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	811	271	T	A	Aca/Gca	-3.34	0	0	benign	0.04	neutral	0.53	neutral	4.2	neutral	0.37	deleterious	-4.12	medium_impact	2.22	0.87	neutral	0.77	neutral	0.46	7.16	deleterious	0.26	0.45	0.61	disease	0.39	neutral	0.28	neutral	0.59	disease	2	0.43	neutral	0.75	deleterious	-3	neutral	0.20	neutral	0.47	medium_impact	0.24	medium_impact	0.72	medium_impact	0.28	0.8	0.58	8.4	0.32	N	0.08	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5280	5280	A	C	MI.14462	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	811	271	T	P	Aca/Cca	-3.34	0	0	probably_damaging	0.9	neutral	0.18	neutral	4.1	neutral	-2.45	deleterious	-5.23	high_impact	3.96	0.77	neutral	0.33	neutral	1.94	15.82	deleterious	0.04	0.35	0.87	disease	0.8	disease	0.7	disease	0.66	disease	3	0.94	neutral	0.14	neutral	2	deleterious	0.76	deleterious	-1.67	low_impact	-0.16	medium_impact	2.19	high_impact	0.24	0.8	0.58	8.4	0.34	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5281	5281	C	A	MI.14463	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	812	271	T	K	aCa/aAa	1.98	0	0	possibly_damaging	0.76	neutral	0.41	neutral	4.1	neutral	-2.19	deleterious	-5.21	medium_impact	3.4	0.88	neutral	0.37	neutral	2.72	20.90	deleterious	0.05	0.35	0.83	disease	0.8	disease	0.67	disease	0.65	disease	3	0.76	neutral	0.33	neutral	0	NA	0.73	deleterious	-1.26	low_impact	0.12	medium_impact	1.72	medium_impact	0.32	0.8	0.58	8.4	0.37	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5281	5281	C	T	MI.14464	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	812	271	T	M	aCa/aTa	1.98	0	0	probably_damaging	0.97	neutral	0.25	neutral	4.16	neutral	-0.75	deleterious	-4.8	medium_impact	2.03	0.88	neutral	0.83	neutral	2.75	21.10	deleterious	0.1	0.4	0.41	neutral	0.62	disease	0.42	neutral	0.34	neutral	3	0.97	neutral	0.14	neutral	1	deleterious	0.67	deleterious	-2.18	low_impact	-0.06	medium_impact	0.56	medium_impact	0.46	0.8	0.58	8.4	0.41	N	0.24	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5283	5283	A	G	MI.14465	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	814	272	K	E	Aaa/Gaa	-4.5	0	0	possibly_damaging	0.7	neutral	0.31	neutral	4.25	neutral	0.56	deleterious	-3.42	low_impact	1.78	0.93	neutral	0.65	neutral	4.05	23.70	deleterious	0.26	0.45	0.6	disease	0.86	disease	0.58	disease	0.64	disease	3	0.76	neutral	0.31	neutral	-3	neutral	0.66	deleterious	-1.13	low_impact	0.02	medium_impact	0.35	medium_impact	0.56	0.8	NA	NA	0.39	N	0.73	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5283	5283	A	C	MI.14466	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	814	272	K	Q	Aaa/Caa	-4.5	0	0	possibly_damaging	0.84	neutral	0.36	neutral	4.22	neutral	0.08	deleterious	-3.38	medium_impact	2.36	0.86	neutral	0.51	neutral	3.48	23.10	deleterious	0.43	0.55	0.68	disease	0.76	disease	0.54	disease	0.6	disease	2	0.86	neutral	0.26	neutral	0	NA	0.70	deleterious	-1.46	low_impact	0.07	medium_impact	0.84	medium_impact	0.40	0.8	NA	NA	0.31	N	0.66	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5284	5284	A	C	MI.14467	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	815	272	K	T	aAa/aCa	2.9	0.98	0	possibly_damaging	0.8	neutral	0.43	neutral	4.16	neutral	-1	deleterious	-5.02	low_impact	1.43	0.9	neutral	0.66	neutral	2.36	18.55	deleterious	0.13	0.4	0.42	neutral	0.7	disease	0.31	neutral	0.17	neutral	7	0.79	neutral	0.32	neutral	-3	neutral	0.61	deleterious	-1.35	low_impact	0.14	medium_impact	0.06	medium_impact	0.33	0.8	NA	NA	0.51	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5284	5284	A	T	MI.14468	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	815	272	K	M	aAa/aTa	2.9	0.98	0	benign	0.21	neutral	0.29	neutral	4.1	deleterious	-3.07	deleterious	-5.05	medium_impact	2.06	0.88	neutral	0.71	neutral	3.69	23.30	deleterious	0.14	0.4	0.88	disease	0.72	disease	0.43	neutral	0.43	neutral	1	0.65	neutral	0.54	deleterious	-3	neutral	0.38	neutral	-0.27	medium_impact	-0.01	medium_impact	0.59	medium_impact	0.26	0.8	NA	NA	0.5	N	0.41	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5285	5285	A	C	MI.14469	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	816	272	K	N	aaA/aaC	2.21	0.99	0	benign	0.09	neutral	0.33	neutral	4.16	neutral	-0.61	deleterious	-4.05	low_impact	1.66	0.91	neutral	0.82	neutral	3.61	23.20	deleterious	0.57	0.65	0.45	neutral	0.69	disease	0.3	neutral	0.17	neutral	7	0.63	neutral	0.62	deleterious	-6	neutral	0.24	neutral	0.12	medium_impact	0.04	medium_impact	0.25	medium_impact	0.36	0.8	NA	NA	0.55	P	0.64	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8367	8367	T	A	MI.1447	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	2	1	M	K	aTg/aAg	8.46	1	0	possibly_damaging	0.88	deleterious	0	deleterious	-2.13	deleterious	-13.27	deleterious	-5.96	NA	NA	0.87	neutral	0.06	damaging	3.83	23.40	deleterious	0.18003069	0.85	0.78	disease	0.21	neutral	0.75	disease	0.26	neutral	5	1	deleterious	0.06	neutral	3	deleterious	0.73	deleterious	NA	NA	NA	NA	NA	NA	0.33	0.85	20.59	8.49	0.59	P	0.93	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5285	5285	A	T	MI.14470	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	816	272	K	N	aaA/aaT	2.21	0.99	0	benign	0.09	neutral	0.33	neutral	4.16	neutral	-0.61	deleterious	-4.05	low_impact	1.66	0.91	neutral	0.82	neutral	3.69	23.30	deleterious	0.57	0.65	0.45	neutral	0.69	disease	0.3	neutral	0.17	neutral	7	0.63	neutral	0.62	deleterious	-6	neutral	0.24	neutral	0.12	medium_impact	0.04	medium_impact	0.25	medium_impact	0.36	0.8	NA	NA	0.56	P	0.64	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5286	5286	A	T	MI.14471	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	817	273	N	Y	Aac/Tac	0.82	0.99	0	probably_damaging	1	neutral	1	neutral	4.12	neutral	-2	deleterious	-7.62	medium_impact	2.46	0.89	neutral	0.3	neutral	3.48	23.10	deleterious	0.23	0.45	0.9	disease	0.8	disease	0.4	neutral	0.61	disease	2	1	deleterious	0.5	deleterious	1	deleterious	0.85	deleterious	-3.54	low_impact	1.87	high_impact	0.93	medium_impact	0.20	0.8	NA	NA	0.34	N	0.64	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5286	5286	A	C	MI.14472	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	817	273	N	H	Aac/Cac	0.82	0.99	0	probably_damaging	1	neutral	0.53	neutral	4.14	neutral	-1.06	deleterious	-4.77	medium_impact	1.95	0.86	neutral	0.35	neutral	1.93	15.79	deleterious	0.54	0.6	0.87	disease	0.61	disease	0.36	neutral	0.5	disease	0	1	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.24	medium_impact	0.5	medium_impact	0.15	0.8	NA	NA	0.35	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5286	5286	A	G	MI.14473	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	817	273	N	D	Aac/Gac	0.82	0.99	0	probably_damaging	1	neutral	0.24	neutral	4.16	neutral	-0.5	deleterious	-4.76	medium_impact	2.89	0.89	neutral	0.11	damaging	3.72	23.30	deleterious	0.73	0.75	0.8	disease	0.71	disease	0.63	disease	0.69	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.07	medium_impact	1.29	medium_impact	0.39	0.8	NA	NA	0.5	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5287	5287	A	C	MI.14474	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	818	273	N	T	aAc/aCc	2.21	1	0	probably_damaging	1	neutral	0.42	neutral	4.17	neutral	-0.39	deleterious	-5.71	medium_impact	2.25	0.84	neutral	0.18	damaging	3.36	22.90	deleterious	0.4	0.5	0.56	disease	0.66	disease	0.61	disease	0.6	disease	2	1	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.13	medium_impact	0.75	medium_impact	0.24	0.8	NA	NA	0.4	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5287	5287	A	G	MI.14475	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	818	273	N	S	aAc/aGc	2.21	1	0	probably_damaging	1	neutral	0.53	neutral	4.27	neutral	0.56	deleterious	-4.75	low_impact	1.51	0.87	neutral	0.23	damaging	2.99	22.20	deleterious	0.64	0.7	0.44	neutral	0.65	disease	0.62	disease	0.6	disease	2	1	deleterious	0.27	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	0.24	medium_impact	0.13	medium_impact	0.25	0.8	NA	NA	0.38	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5287	5287	A	T	MI.14476	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	818	273	N	I	aAc/aTc	2.21	1	0	probably_damaging	1	neutral	0.48	neutral	4.12	neutral	-2.22	deleterious	-8.56	medium_impact	2.73	0.87	neutral	0.11	damaging	3.84	23.40	deleterious	0.22	0.45	0.67	disease	0.87	disease	0.59	disease	0.72	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.19	medium_impact	1.15	medium_impact	0.16	0.8	NA	NA	0.42	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5288	5288	C	A	MI.14477	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	819	273	N	K	aaC/aaA	6.6	1	0	probably_damaging	1	neutral	0.33	neutral	4.19	neutral	-0.13	deleterious	-5.71	medium_impact	2.34	0.91	neutral	0.1	damaging	4.45	24.20	deleterious	0.6	0.65	0.71	disease	0.8	disease	0.63	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.04	medium_impact	0.83	medium_impact	0.42	0.8	NA	NA	0.55	P	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5288	5288	C	G	MI.14478	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	819	273	N	K	aaC/aaG	6.6	1	0	probably_damaging	1	neutral	0.33	neutral	4.19	neutral	-0.13	deleterious	-5.71	medium_impact	2.34	0.91	neutral	0.1	damaging	3.99	23.60	deleterious	0.6	0.65	0.71	disease	0.8	disease	0.63	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.04	medium_impact	0.83	medium_impact	0.42	0.8	NA	NA	0.55	P	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5289	5289	A	T	MI.14479	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	820	274	N	Y	Aat/Tat	-0.8	0	0	possibly_damaging	0.89	neutral	1	neutral	4.08	neutral	-2.61	deleterious	-5.48	medium_impact	2.84	0.9	neutral	0.75	neutral	1.87	15.40	deleterious	0.13	0.4	0.71	disease	0.81	disease	0.59	disease	0.62	disease	2	0.89	neutral	0.56	deleterious	0	NA	0.73	deleterious	-1.63	low_impact	1.87	high_impact	1.25	medium_impact	0.20	0.8	1.15	8.25	0.25	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8367	8367	T	C	MI.1448	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	2	1	M	T	aTg/aCg	8.46	1	0	possibly_damaging	0.88	deleterious	0	deleterious	-2.12	deleterious	-12.66	deleterious	-5.96	NA	NA	0.88	neutral	0.09	damaging	2.67	20.60	deleterious	0.34561211	0.85	0.73	disease	0.2	neutral	0.73	disease	0.26	neutral	5	1	deleterious	0.06	neutral	3	deleterious	0.71	deleterious	NA	NA	NA	NA	NA	NA	0.24	0.85	20.59	8.49	0.58	P	0.88	NA	NA	0.50	.	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5289	5289	A	C	MI.14480	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	820	274	N	H	Aat/Cat	-0.8	0	0	probably_damaging	0.92	neutral	0.53	neutral	4.12	neutral	-1.57	deleterious	-3.08	medium_impact	2.63	0.82	neutral	0.94	neutral	0.34	6.05	deleterious	0.49	0.55	0.82	disease	0.61	disease	0.44	neutral	0.35	neutral	3	0.92	neutral	0.31	neutral	1	deleterious	0.71	deleterious	-1.77	low_impact	0.24	medium_impact	1.07	medium_impact	0.21	0.8	1.15	8.25	0.28	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5289	5289	A	G	MI.14481	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	820	274	N	D	Aat/Gat	-0.8	0	0	benign	0.02	neutral	0.23	neutral	4.14	neutral	-0.96	neutral	-1.75	low_impact	0.92	0.87	neutral	0.99	neutral	0.25	5.21	deleterious	0.77	0.8	0.71	disease	0.35	neutral	0.41	neutral	0.64	disease	3	0.76	neutral	0.61	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	-0.08	medium_impact	-0.37	medium_impact	0.34	0.8	1.15	8.25	0.47	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5290	5290	A	G	MI.14482	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	821	274	N	S	aAt/aGt	-0.8	0	0	benign	0.04	neutral	0.42	neutral	4.16	neutral	-0.72	deleterious	-2.7	low_impact	1.51	0.83	neutral	0.98	neutral	0.19	4.59	deleterious	0.6	0.65	0.43	neutral	0.61	disease	0.41	neutral	0.2	neutral	6	0.54	neutral	0.69	deleterious	-6	neutral	0.21	neutral	0.47	medium_impact	0.13	medium_impact	0.13	medium_impact	0.28	0.8	1.15	8.25	0.36	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5290	5290	A	C	MI.14483	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	821	274	N	T	aAt/aCt	-0.8	0	0	benign	0.36	neutral	0.4	neutral	4.13	neutral	-1.06	deleterious	-3.84	medium_impact	2.84	0.91	neutral	0.61	neutral	1.60	13.86	neutral	0.39	0.5	0.44	neutral	0.69	disease	0.63	disease	0.68	disease	4	0.53	neutral	0.52	deleterious	-3	neutral	0.38	neutral	-0.57	medium_impact	0.11	medium_impact	1.25	medium_impact	0.23	0.8	1.15	8.25	0.36	N	0.60	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5290	5290	A	T	MI.14484	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	821	274	N	I	aAt/aTt	-0.8	0	0	possibly_damaging	0.85	neutral	0.42	neutral	4.07	neutral	-2.99	deleterious	-6.31	medium_impact	3.29	0.9	neutral	0.47	neutral	2.39	18.76	deleterious	0.13	0.4	0.49	neutral	0.86	disease	0.61	disease	0.73	disease	5	0.85	neutral	0.29	neutral	0	NA	0.66	deleterious	-1.49	low_impact	0.13	medium_impact	1.63	medium_impact	0.17	0.8	1.15	8.25	0.39	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5291	5291	T	A	MI.14485	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	822	274	N	K	aaT/aaA	0.82	0	0	benign	0.36	neutral	0.29	neutral	4.16	neutral	-0.63	deleterious	-3.69	medium_impact	2.23	0.89	neutral	0.69	neutral	2.58	19.99	deleterious	0.51	0.6	0.76	disease	0.81	disease	0.65	disease	0.61	disease	2	0.66	neutral	0.47	neutral	-3	neutral	0.53	deleterious	-0.57	medium_impact	-0.01	medium_impact	0.73	medium_impact	0.40	0.8	1.15	8.25	0.42	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5291	5291	T	G	MI.14486	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	822	274	N	K	aaT/aaG	0.82	0	0	benign	0.36	neutral	0.29	neutral	4.16	neutral	-0.63	deleterious	-3.69	medium_impact	2.23	0.89	neutral	0.69	neutral	2.20	17.52	deleterious	0.51	0.6	0.76	disease	0.81	disease	0.65	disease	0.61	disease	2	0.66	neutral	0.47	neutral	-3	neutral	0.53	deleterious	-0.57	medium_impact	-0.01	medium_impact	0.73	medium_impact	0.40	0.8	1.15	8.25	0.4	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5292	5292	A	C	MI.14487	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	823	275	S	R	Agc/Cgc	-5.89	0	0	benign	0.26	neutral	0.15	neutral	4.15	neutral	-1.16	neutral	-2.31	medium_impact	2.23	0.86	neutral	0.44	neutral	0.60	8.16	deleterious	0.11	0.4	0.76	disease	0.63	disease	0.62	disease	0.72	disease	4	0.82	neutral	0.45	neutral	-3	neutral	0.30	neutral	-0.38	medium_impact	-0.21	medium_impact	0.73	medium_impact	0.55	0.8	0.58	7.49	0.31	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5292	5292	A	T	MI.14488	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	823	275	S	C	Agc/Tgc	-5.89	0	0	possibly_damaging	0.76	neutral	0.12	neutral	4.11	deleterious	-3.87	deleterious	-3.15	medium_impact	2.44	0.94	neutral	0.91	neutral	0.34	6.03	deleterious	0.14	0.4	0.42	neutral	0.46	neutral	0.32	neutral	0.5	disease	0	0.91	neutral	0.18	neutral	0	NA	0.45	deleterious	-1.26	low_impact	-0.27	medium_impact	0.91	medium_impact	0.28	0.8	0.58	7.49	0.52	N	0.29	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5292	5292	A	G	MI.14489	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	823	275	S	G	Agc/Ggc	-5.89	0	0	benign	0.08	neutral	0.25	neutral	4.17	neutral	-0.66	neutral	-2.33	low_impact	1.74	0.93	neutral	0.83	neutral	0.30	5.71	deleterious	0.26	0.45	0.54	disease	0.29	neutral	0.44	neutral	0.49	neutral	0	0.72	neutral	0.59	deleterious	-6	neutral	0.15	neutral	0.17	medium_impact	-0.06	medium_impact	0.32	medium_impact	0.57	0.8	0.58	7.49	0.43	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8368	8368	G	T	MI.1449	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	3	1	M	I	atG/atT	7.53	1	0	possibly_damaging	0.82	deleterious	0	deleterious	-2.12	deleterious	-11.44	deleterious	-3.97	NA	NA	0.89	neutral	0.06	damaging	3.27	22.80	deleterious	0.29054267	0.85	0.52	disease	0.1	neutral	0.73	disease	0.19	neutral	6	1	deleterious	0.09	neutral	3	deleterious	0.57	deleterious	NA	NA	NA	NA	NA	NA	0.56	0.85	20.59	8.49	0.6	P	0.71	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5293	5293	G	A	MI.14490	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	824	275	S	N	aGc/aAc	0.13	0	0	benign	0	neutral	0.21	neutral	4.17	neutral	-1.17	neutral	0.13	neutral_impact	-0.38	0.93	neutral	0.94	neutral	-0.95	0.02	neutral	0.61	0.65	0.78	disease	0.2	neutral	0.24	neutral	0.53	disease	1	0.79	neutral	0.61	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	-0.11	medium_impact	-1.46	low_impact	0.34	0.8	0.58	7.49	0.46	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5293	5293	G	C	MI.14491	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	824	275	S	T	aGc/aCc	0.13	0	0	benign	0	neutral	0.32	neutral	4.18	neutral	-0.7	neutral	-1.38	low_impact	1.2	0.95	neutral	0.78	neutral	0.19	4.55	deleterious	0.33	0.5	0.5	neutral	0.21	neutral	0.28	neutral	0.27	neutral	5	0.68	neutral	0.66	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.03	medium_impact	-0.13	medium_impact	0.58	0.8	0.58	7.49	0.47	N	0.16	polymorphism	1	0.02	rs28690990	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5293	5293	G	T	MI.14492	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	824	275	S	I	aGc/aTc	0.13	0	0	benign	0.2	neutral	0.38	neutral	4.14	neutral	-1.58	deleterious	-2.97	low_impact	1.36	0.88	neutral	0.68	neutral	1.02	10.78	neutral	0.12	0.4	0.41	neutral	0.54	disease	0.34	neutral	0.49	neutral	0	0.54	neutral	0.59	deleterious	-6	neutral	0.22	neutral	-0.25	medium_impact	0.09	medium_impact	0	medium_impact	0.30	0.8	0.58	7.49	0.36	N	0.67	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5295	5295	C	A	MI.14493	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	826	276	L	I	Ctc/Atc	-1.96	0	0	benign	0.06	neutral	0.69	neutral	4.13	neutral	-1.09	neutral	1.23	neutral_impact	-1	0.87	neutral	0.89	neutral	1.40	12.80	neutral	0.4	0.5	0.46	neutral	0.05	neutral	0.16	neutral	0.22	neutral	6	0.22	neutral	0.82	deleterious	-6	neutral	0.14	neutral	0.3	medium_impact	0.4	medium_impact	-1.99	low_impact	0.52	0.8	1.73	8.64	0.41	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5295	5295	C	G	MI.14494	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	826	276	L	V	Ctc/Gtc	-1.96	0	0	benign	0.23	neutral	0.59	neutral	4.12	neutral	-0.9	neutral	0.52	neutral_impact	0.46	0.89	neutral	0.93	neutral	2.28	18.00	deleterious	0.37	0.5	0.55	disease	0.18	neutral	0.38	neutral	0.38	neutral	3	0.3	neutral	0.68	deleterious	-6	neutral	0.31	neutral	-0.32	medium_impact	0.3	medium_impact	-0.76	medium_impact	0.61	0.8	1.73	8.64	0.37	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5295	5295	C	T	MI.14495	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	826	276	L	F	Ctc/Ttc	-1.96	0	0	benign	0.02	neutral	0.77	neutral	4.06	neutral	-1.88	neutral	-1.56	neutral_impact	0.72	0.97	neutral	0.85	neutral	2.94	22.00	deleterious	0.26	0.45	0.72	disease	0.27	neutral	0.4	neutral	0.57	disease	1	0.18	neutral	0.88	deleterious	-6	neutral	0.20	neutral	0.75	medium_impact	0.5	medium_impact	-0.54	medium_impact	0.64	0.8	1.73	8.64	0.27	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5296	5296	T	A	MI.14496	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	827	276	L	H	cTc/cAc	-1.49	0	0	possibly_damaging	0.87	neutral	0.46	neutral	3.99	deleterious	-4.09	deleterious	-4.48	low_impact	1.58	0.86	neutral	0.64	neutral	4.18	23.80	deleterious	0.05	0.35	0.85	disease	0.35	neutral	0.53	disease	0.65	disease	3	0.86	neutral	0.3	neutral	-3	neutral	0.67	deleterious	-1.55	low_impact	0.17	medium_impact	0.19	medium_impact	0.18	0.8	1.73	8.64	0.35	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5296	5296	T	G	MI.14497	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	827	276	L	R	cTc/cGc	-1.49	0	0	possibly_damaging	0.89	neutral	0.3	neutral	3.99	deleterious	-3.82	deleterious	-4.47	medium_impact	2.62	0.84	neutral	0.44	neutral	4.27	23.90	deleterious	0.02	0.35	0.8	disease	0.62	disease	0.58	disease	0.72	disease	4	0.91	neutral	0.21	neutral	0	NA	0.75	deleterious	-1.63	low_impact	0	medium_impact	1.06	medium_impact	0.17	0.8	1.73	8.64	0.33	N	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5296	5296	T	C	MI.14498	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	827	276	L	P	cTc/cCc	-1.49	0	0	probably_damaging	0.93	neutral	0.39	neutral	4.02	neutral	-2.97	deleterious	-4.48	neutral_impact	-0.08	0.85	neutral	0.86	neutral	2.69	20.80	deleterious	0.03	0.35	0.42	neutral	0.43	neutral	0.43	neutral	0.46	neutral	1	0.93	neutral	0.23	neutral	-2	neutral	0.69	deleterious	-1.83	low_impact	0.1	medium_impact	-1.21	low_impact	0.11	0.8	1.73	8.64	0.31	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5298	5298	A	G	MI.14499	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	829	277	I	V	Atc/Gtc	-11.21	0	0	benign	0.01	neutral	0.46	neutral	4.26	neutral	0.54	neutral	-0.62	low_impact	1.3	0.98	neutral	0.95	neutral	0.09	3.46	deleterious	0.6	0.65	0.56	disease	0.16	neutral	0.36	neutral	0.39	neutral	2	0.53	neutral	0.73	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.17	medium_impact	-0.05	medium_impact	0.40	0.8	4.32	7.56	0.37	N	0.62	polymorphism	1	0.02	.	.	.	.	.	papillary thyroid carcinoma	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8594	8594	T	A	MI.145	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	68	23	I	N	aTc/aAc	2.67	0.98	0	probably_damaging	0.91	neutral	0.12	neutral	4.26	neutral	-2.82	deleterious	-4.03	low_impact	1.36	0.87	neutral	0.37	neutral	4.16	23.80	deleterious	0.3	0.65	0.86	disease	0.73	disease	0.55	disease	0.75	disease	5	0.96	neutral	0.11	neutral	-2	neutral	0.78	deleterious	-1.71	low_impact	-0.2	medium_impact	0.07	medium_impact	0.60	0.9	19.03	10.37	0.46	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8368	8368	G	C	MI.1450	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	3	1	M	I	atG/atC	7.53	1	0	possibly_damaging	0.82	deleterious	0	deleterious	-2.12	deleterious	-11.44	deleterious	-3.97	NA	NA	0.89	neutral	0.06	damaging	3.14	22.60	deleterious	0.29054267	0.85	0.52	disease	0.1	neutral	0.73	disease	0.19	neutral	6	1	deleterious	0.09	neutral	3	deleterious	0.57	deleterious	NA	NA	NA	NA	NA	NA	0.56	0.85	20.59	8.49	0.6	P	0.71	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5298	5298	A	C	MI.14500	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	829	277	I	L	Atc/Ctc	-11.21	0	0	benign	0.01	neutral	1	neutral	4.31	neutral	0.61	neutral	-1.17	low_impact	1.1	0.94	neutral	0.95	neutral	0.64	8.45	deleterious	0.22	0.45	0.51	disease	0.19	neutral	0.25	neutral	0.27	neutral	5	0.01	neutral	1	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	1.87	high_impact	-0.22	medium_impact	0.63	0.8	4.32	7.56	0.3	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5298	5298	A	T	MI.14501	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	829	277	I	F	Atc/Ttc	-11.21	0	0	possibly_damaging	0.52	neutral	0.66	neutral	4.21	neutral	-0.53	deleterious	-3.07	low_impact	0.96	0.89	neutral	0.81	neutral	1.09	11.18	neutral	0.21	0.45	0.62	disease	0.46	neutral	0.34	neutral	0.57	disease	1	0.44	neutral	0.57	deleterious	-3	neutral	0.52	deleterious	-0.83	medium_impact	0.37	medium_impact	-0.34	medium_impact	0.56	0.8	4.32	7.56	0.31	N	0.61	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5299	5299	T	A	MI.14502	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	830	277	I	N	aTc/aAc	-1.96	0	0	possibly_damaging	0.75	neutral	0.14	neutral	4.09	deleterious	-3.13	deleterious	-5.44	high_impact	3.59	0.87	neutral	0.41	neutral	4.23	23.90	deleterious	0.09	0.4	0.83	disease	0.58	disease	0.63	disease	0.67	disease	3	0.9	neutral	0.2	neutral	1	deleterious	0.63	deleterious	-1.23	low_impact	-0.23	medium_impact	1.88	medium_impact	0.24	0.8	4.32	7.56	0.43	N	0.88	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5299	5299	T	G	MI.14503	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	830	277	I	S	aTc/aGc	-1.96	0	0	benign	0.29	neutral	0.45	neutral	4.12	neutral	-1.69	deleterious	-4.45	medium_impact	2.12	0.81	neutral	0.82	neutral	2.57	19.91	deleterious	0.04	0.35	0.55	disease	0.53	disease	0.42	neutral	0.27	neutral	5	0.46	neutral	0.58	deleterious	-3	neutral	0.38	neutral	-0.44	medium_impact	0.16	medium_impact	0.64	medium_impact	0.24	0.8	4.32	7.56	0.32	N	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5299	5299	T	C	MI.14504	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	830	277	I	T	aTc/aCc	-1.96	0	0	benign	0.03	neutral	0.55	neutral	4.15	neutral	-0.9	deleterious	-3.46	low_impact	1.36	0.9	neutral	0.97	neutral	0.41	6.68	deleterious	0.14	0.4	0.69	disease	0.22	neutral	0.39	neutral	0.5	neutral	0	0.41	neutral	0.76	deleterious	-6	neutral	0.19	neutral	0.59	medium_impact	0.26	medium_impact	0	medium_impact	0.24	0.8	4.32	7.56	0.37	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5300	5300	C	G	MI.14505	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	831	277	I	M	atC/atG	-0.34	0	0.01	possibly_damaging	0.68	neutral	0.59	neutral	4.12	neutral	-1.77	neutral	-1.54	low_impact	1.08	0.84	neutral	0.95	neutral	0.54	7.76	deleterious	0.35	0.5	0.6	disease	0.2	neutral	0.31	neutral	0.46	neutral	1	0.63	neutral	0.46	neutral	-3	neutral	0.51	deleterious	-1.1	low_impact	0.3	medium_impact	-0.24	medium_impact	0.64	0.8	4.32	7.56	0.32	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5300	5300	C	A	MI.14506	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	831	277	I	M	atC/atA	-0.34	0	0.01	possibly_damaging	0.68	neutral	0.59	neutral	4.12	neutral	-1.77	neutral	-1.54	low_impact	1.08	0.84	neutral	0.95	neutral	1.07	11.04	neutral	0.35	0.5	0.6	disease	0.2	neutral	0.31	neutral	0.46	neutral	1	0.63	neutral	0.46	neutral	-3	neutral	0.51	deleterious	-1.1	low_impact	0.3	medium_impact	-0.24	medium_impact	0.64	0.8	4.32	7.56	0.32	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5301	5301	A	G	MI.14507	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	832	278	I	V	Atc/Gtc	-10.98	0	0.08	benign	0.04	neutral	0.75	neutral	4.23	neutral	0.19	neutral	-0.51	neutral_impact	0.62	0.96	neutral	0.9	neutral	0.03	2.86	deleterious	0.55	0.6	0.46	neutral	0.11	neutral	0.32	neutral	0.33	neutral	3	0.19	neutral	0.86	deleterious	-6	neutral	0.10	neutral	0.47	medium_impact	0.47	medium_impact	-0.62	medium_impact	0.39	0.8	NA	NA	0.29	N	0.47	polymorphism	1	0.02	rs199794187	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5301	5301	A	C	MI.14508	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	832	278	I	L	Atc/Ctc	-10.98	0	0.08	benign	0	neutral	1	neutral	4.54	neutral	1.71	neutral	0.93	neutral_impact	-1.36	0.87	neutral	0.94	neutral	-0.74	0.06	neutral	0.25	0.45	0.38	neutral	0.14	neutral	0.23	neutral	0.24	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	1.87	high_impact	-2.29	low_impact	0.68	0.85	NA	NA	0.38	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5301	5301	A	T	MI.14509	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	832	278	I	F	Atc/Ttc	-10.98	0	0.08	benign	0	neutral	0.81	neutral	4.13	neutral	-1.35	neutral	-1.64	neutral_impact	0.7	0.89	neutral	0.81	neutral	1.86	15.35	deleterious	0.19	0.45	0.43	neutral	0.41	neutral	0.38	neutral	0.44	neutral	1	0.17	neutral	0.91	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.56	medium_impact	-0.56	medium_impact	0.52	0.8	NA	NA	0.33	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8369	8369	C	T	MI.1451	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	4	2	P	S	Ccc/Tcc	5.22	1	0	probably_damaging	1	deleterious	0.02	neutral	-1.21	deleterious	-9.22	deleterious	-7.95	high_impact	3.9	0.99	neutral	0.45	neutral	3.64	23.20	deleterious	0.46398601	0.85	0.79	disease	0.1	neutral	0.52	disease	0.21	neutral	6	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.6	low_impact	-0.66	medium_impact	2.25	high_impact	0.17	0.85	22.06	7.2	0.65	P	0.94	disease_causing	0.98	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5302	5302	T	A	MI.14510	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	833	278	I	N	aTc/aAc	-6.58	0	0	benign	0.14	neutral	0.24	neutral	4.07	deleterious	-3.39	deleterious	-4.2	low_impact	1.86	0.89	neutral	0.45	neutral	2.61	20.30	deleterious	0.09	0.35	0.69	disease	0.51	disease	0.63	disease	0.68	disease	4	0.72	neutral	0.55	deleterious	-6	neutral	0.26	neutral	-0.08	medium_impact	-0.07	medium_impact	0.42	medium_impact	0.28	0.8	NA	NA	0.39	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5302	5302	T	G	MI.14511	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	833	278	I	S	aTc/aGc	-6.58	0	0	benign	0.06	neutral	0.68	neutral	4.1	neutral	-1.92	deleterious	-3.23	low_impact	1.17	0.88	neutral	0.74	neutral	2.38	18.70	deleterious	0.03	0.35	0.61	disease	0.46	neutral	0.6	disease	0.6	disease	2	0.24	neutral	0.81	deleterious	-6	neutral	0.17	neutral	0.3	medium_impact	0.39	medium_impact	-0.16	medium_impact	0.27	0.8	NA	NA	0.26	N	0.40	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5302	5302	T	C	MI.14512	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	833	278	I	T	aTc/aCc	-6.58	0	0	benign	0	neutral	0.75	neutral	4.14	neutral	-1.53	deleterious	-2.5	neutral_impact	-0.18	0.99	neutral	0.96	neutral	0.01	2.64	deleterious	0.12	0.4	0.63	disease	0.1	neutral	0.31	neutral	0.33	neutral	3	0.24	neutral	0.88	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	0.47	medium_impact	-1.3	low_impact	0.35	0.8	NA	NA	0.33	N	0.06	polymorphism	1	0.07	rs878853115	Benign	not_provided	237470	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5303	5303	C	G	MI.14513	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	834	278	I	M	atC/atG	0.36	0	0	benign	0.01	neutral	0.55	neutral	4.11	neutral	-1.75	neutral	0.83	neutral_impact	-0.82	0.96	neutral	0.92	neutral	-0.67	0.09	neutral	0.33	0.5	0.5	neutral	0.1	neutral	0.25	neutral	0.21	neutral	6	0.44	neutral	0.77	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.26	medium_impact	-1.84	low_impact	0.70	0.85	NA	NA	0.35	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5303	5303	C	A	MI.14514	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	834	278	I	M	atC/atA	0.36	0	0	benign	0.01	neutral	0.55	neutral	4.11	neutral	-1.75	neutral	0.83	neutral_impact	-0.82	0.96	neutral	0.92	neutral	-0.23	0.96	neutral	0.33	0.5	0.5	neutral	0.1	neutral	0.25	neutral	0.21	neutral	6	0.44	neutral	0.77	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.26	medium_impact	-1.84	low_impact	0.70	0.85	NA	NA	0.37	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5304	5304	C	T	MI.14515	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	835	279	P	S	Ccc/Tcc	-2.19	0	0	probably_damaging	1	neutral	0.5	neutral	4.25	neutral	-0.65	deleterious	-5.87	neutral_impact	-0.12	0.84	neutral	0.92	neutral	2.71	20.90	deleterious	0.22	0.45	0.39	neutral	0.38	neutral	0.33	neutral	0.43	neutral	2	1	deleterious	0.25	neutral	-2	neutral	0.70	deleterious	-3.54	low_impact	0.21	medium_impact	-1.25	low_impact	0.24	0.8	NA	NA	0.28	N	0.27	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5304	5304	C	G	MI.14516	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	835	279	P	A	Ccc/Gcc	-2.19	0	0	probably_damaging	1	neutral	0.72	neutral	4.55	neutral	1.85	deleterious	-5.9	neutral_impact	-0.85	0.9	neutral	0.89	neutral	0.90	10.09	neutral	0.18	0.45	0.38	neutral	0.07	neutral	0.3	neutral	0.18	neutral	7	1	deleterious	0.36	neutral	-2	neutral	0.67	deleterious	-3.54	low_impact	0.44	medium_impact	-1.86	low_impact	0.75	0.85	NA	NA	0.38	N	0.42	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5304	5304	C	A	MI.14517	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	835	279	P	T	Ccc/Acc	-2.19	0	0	probably_damaging	1	neutral	0.58	neutral	4.25	neutral	-0.33	deleterious	-6.17	neutral_impact	0.72	0.9	neutral	0.47	neutral	3.68	23.30	deleterious	0.18	0.45	0.55	disease	0.35	neutral	0.46	neutral	0.58	disease	2	1	deleterious	0.29	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.29	medium_impact	-0.54	medium_impact	0.66	0.8	NA	NA	0.32	N	0.60	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5305	5305	C	T	MI.14518	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	836	279	P	L	cCc/cTc	0.82	0.28	0	probably_damaging	1	neutral	0.75	neutral	4.33	neutral	0.61	deleterious	-8.09	neutral_impact	0.57	0.86	neutral	0.12	damaging	4.50	24.30	deleterious	0.12	0.4	0.5	neutral	0.6	disease	0.57	disease	0.67	disease	3	1	deleterious	0.38	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.47	medium_impact	-0.67	medium_impact	0.70	0.85	NA	NA	0.23	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5305	5305	C	A	MI.14519	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	836	279	P	H	cCc/cAc	0.82	0.28	0	probably_damaging	1	neutral	0.52	neutral	4.17	neutral	-2.92	deleterious	-7.29	medium_impact	2.89	0.88	neutral	0.11	damaging	4.13	23.80	deleterious	0.1	0.4	0.59	disease	0.52	disease	0.69	disease	0.69	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.23	medium_impact	1.29	medium_impact	0.41	0.8	NA	NA	0.31	N	0.88	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8369	8369	C	A	MI.1452	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	4	2	P	T	Ccc/Acc	5.22	1	0	probably_damaging	1	deleterious	0	neutral	-1.19	deleterious	-8.28	deleterious	-7.95	high_impact	3.9	0.99	neutral	0.46	neutral	3.43	23.00	deleterious	0.36427644	0.85	0.83	disease	0.12	neutral	0.53	disease	0.22	neutral	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-1.4	low_impact	2.25	high_impact	0.35	0.85	22.06	7.2	0.65	P	0.92	disease_causing	0.98	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5305	5305	C	G	MI.14520	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	836	279	P	R	cCc/cGc	0.82	0.28	0	probably_damaging	1	neutral	0.34	neutral	4.18	neutral	-2.31	deleterious	-7.22	medium_impact	2.54	0.91	neutral	0.13	damaging	3.68	23.30	deleterious	0.08	0.35	0.45	neutral	0.77	disease	0.72	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.05	medium_impact	0.99	medium_impact	0.41	0.8	NA	NA	0.34	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5307	5307	A	G	MI.14521	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	838	280	T	A	Acc/Gcc	-9.82	0	0	benign	0.34	neutral	0.5	neutral	4.22	neutral	0.71	deleterious	-3.64	medium_impact	2.45	0.9	neutral	0.69	neutral	4.04	23.70	deleterious	0.31	0.45	0.74	disease	0.4	neutral	0.38	neutral	0.62	disease	2	0.42	neutral	0.58	deleterious	-3	neutral	0.37	neutral	-0.53	medium_impact	0.21	medium_impact	0.92	medium_impact	0.36	0.8	1.44	7.46	0.38	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5307	5307	A	T	MI.14522	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	838	280	T	S	Acc/Tcc	-9.82	0	0	benign	0.04	neutral	0.42	neutral	4.12	neutral	-1.11	deleterious	-2.75	medium_impact	1.96	0.87	neutral	0.73	neutral	2.83	21.50	deleterious	0.36	0.5	0.61	disease	0.52	disease	0.35	neutral	0.23	neutral	5	0.55	neutral	0.69	deleterious	-3	neutral	0.21	neutral	0.47	medium_impact	0.13	medium_impact	0.51	medium_impact	0.54	0.8	1.44	7.46	0.33	N	0.34	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5307	5307	A	C	MI.14523	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	838	280	T	P	Acc/Ccc	-9.82	0	0	possibly_damaging	0.86	neutral	0.21	neutral	4.06	deleterious	-3	deleterious	-4.8	medium_impact	3.29	0.76	neutral	0.3	neutral	4.11	23.70	deleterious	0.05	0.35	0.86	disease	0.8	disease	0.71	disease	0.66	disease	3	0.91	neutral	0.18	neutral	0	NA	0.73	deleterious	-1.52	low_impact	-0.11	medium_impact	1.63	medium_impact	0.28	0.8	1.44	7.46	0.34	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5308	5308	C	T	MI.14524	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	839	280	T	I	aCc/aTc	0.13	0	0	possibly_damaging	0.45	neutral	0.43	neutral	4.21	neutral	0.25	deleterious	-4.32	low_impact	1.46	0.89	neutral	0.7	neutral	3.00	22.20	deleterious	0.11	0.4	0.75	disease	0.68	disease	0.36	neutral	0.24	neutral	5	0.53	neutral	0.49	deleterious	-3	neutral	0.47	deleterious	-0.72	medium_impact	0.14	medium_impact	0.09	medium_impact	0.64	0.8	1.44	7.46	0.38	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5308	5308	C	A	MI.14525	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	839	280	T	N	aCc/aAc	0.13	0	0	possibly_damaging	0.59	neutral	0.3	neutral	4.06	deleterious	-3.17	deleterious	-3.88	high_impact	4.1	0.84	neutral	0.46	neutral	3.75	23.30	deleterious	0.25	0.45	0.36	neutral	0.69	disease	0.61	disease	0.64	disease	3	0.71	neutral	0.36	neutral	1	deleterious	0.49	deleterious	-0.94	medium_impact	0	medium_impact	2.31	high_impact	0.50	0.8	1.44	7.46	0.44	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5308	5308	C	G	MI.14526	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	839	280	T	S	aCc/aGc	0.13	0	0	benign	0.04	neutral	0.42	neutral	4.12	neutral	-1.11	deleterious	-2.75	medium_impact	1.96	0.87	neutral	0.73	neutral	2.46	19.20	deleterious	0.36	0.5	0.61	disease	0.52	disease	0.35	neutral	0.23	neutral	5	0.55	neutral	0.69	deleterious	-3	neutral	0.21	neutral	0.47	medium_impact	0.13	medium_impact	0.51	medium_impact	0.54	0.8	1.44	7.46	0.33	N	0.34	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5310	5310	A	G	MI.14527	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	841	281	I	V	Atc/Gtc	-7.51	0	0	benign	0.01	neutral	0.48	neutral	4.19	neutral	-0.03	neutral	-0.61	neutral_impact	0.8	0.98	neutral	0.95	neutral	0.04	3.01	deleterious	0.42	0.55	0.48	neutral	0.2	neutral	0.31	neutral	0.33	neutral	3	0.5	neutral	0.74	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.19	medium_impact	-0.47	medium_impact	0.50	0.8	2.31	8.33	0.4	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5310	5310	A	C	MI.14528	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	841	281	I	L	Atc/Ctc	-7.51	0	0	benign	0.04	neutral	1	neutral	4.2	neutral	-0.29	neutral	0.26	neutral_impact	-0.1	0.89	neutral	0.97	neutral	-0.72	0.06	neutral	0.18	0.45	0.41	neutral	0.26	neutral	0.2	neutral	0.45	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.12	neutral	0.47	medium_impact	1.87	high_impact	-1.23	low_impact	0.52	0.8	2.31	8.33	0.32	N	0.22	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5310	5310	A	T	MI.14529	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	841	281	I	F	Atc/Ttc	-7.51	0	0	benign	0.39	neutral	0.71	neutral	3.98	neutral	-2.07	neutral	-1.66	low_impact	0.82	0.91	neutral	0.94	neutral	0.83	9.65	deleterious	0.16	0.45	0.68	disease	0.54	disease	0.32	neutral	0.25	neutral	5	0.29	neutral	0.66	deleterious	-6	neutral	0.37	neutral	-0.62	medium_impact	0.42	medium_impact	-0.45	medium_impact	0.48	0.8	2.31	8.33	0.26	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8369	8369	C	G	MI.1453	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	4	2	P	A	Ccc/Gcc	5.22	1	0	probably_damaging	0.99	deleterious	0.01	neutral	-1.21	deleterious	-8.92	deleterious	-7.95	high_impact	3.9	0.99	neutral	0.51	neutral	2.85	21.60	deleterious	0.40681744	0.85	0.76	disease	0.06	neutral	0.53	disease	0.16	neutral	7	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.65	low_impact	-0.84	medium_impact	2.25	high_impact	0.40	0.85	22.06	7.2	0.64	P	0.83	disease_causing	0.96	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5311	5311	T	G	MI.14530	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	842	281	I	S	aTc/aGc	-7.05	0	0	benign	0.14	neutral	0.39	neutral	3.94	deleterious	-3.04	deleterious	-3.24	medium_impact	1.97	0.87	neutral	0.88	neutral	1.32	12.35	neutral	0.05	0.35	0.71	disease	0.69	disease	0.41	neutral	0.37	neutral	3	0.54	neutral	0.63	deleterious	-3	neutral	0.30	neutral	-0.08	medium_impact	0.1	medium_impact	0.51	medium_impact	0.28	0.8	2.31	8.33	0.33	N	0.47	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5311	5311	T	C	MI.14531	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	842	281	I	T	aTc/aCc	-7.05	0	0	benign	0	neutral	0.59	neutral	3.96	neutral	-2.62	neutral	-2.24	low_impact	1.38	0.97	neutral	0.99	neutral	0.07	3.26	deleterious	0.12	0.4	0.72	disease	0.34	neutral	0.35	neutral	0.64	disease	3	0.4	neutral	0.8	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	0.3	medium_impact	0.02	medium_impact	0.30	0.8	2.31	8.33	0.3	N	0.14	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5311	5311	T	A	MI.14532	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	842	281	I	N	aTc/aAc	-7.05	0	0	benign	0.39	neutral	0.32	neutral	3.91	deleterious	-4.42	deleterious	-4.27	high_impact	3.6	0.89	neutral	0.41	neutral	2.66	20.60	deleterious	0.09	0.35	0.93	disease	0.68	disease	0.6	disease	0.7	disease	4	0.62	neutral	0.47	neutral	-2	neutral	0.55	deleterious	-0.62	medium_impact	0.03	medium_impact	1.89	medium_impact	0.36	0.8	2.31	8.33	0.39	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5312	5312	C	A	MI.14533	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	843	281	I	M	atC/atA	-0.11	0	0	benign	0.02	neutral	0.38	neutral	3.97	neutral	-2.48	neutral	-0.59	low_impact	1.75	0.9	neutral	0.96	neutral	0.99	10.62	neutral	0.29	0.45	0.65	disease	0.29	neutral	0.25	neutral	0.56	disease	1	0.6	neutral	0.68	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	0.09	medium_impact	0.33	medium_impact	0.53	0.8	2.31	8.33	0.46	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5312	5312	C	G	MI.14534	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	843	281	I	M	atC/atG	-0.11	0	0	benign	0.02	neutral	0.38	neutral	3.97	neutral	-2.48	neutral	-0.59	low_impact	1.75	0.9	neutral	0.96	neutral	0.47	7.17	deleterious	0.29	0.45	0.65	disease	0.29	neutral	0.25	neutral	0.56	disease	1	0.6	neutral	0.68	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	0.09	medium_impact	0.33	medium_impact	0.53	0.8	2.31	8.33	0.45	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5313	5313	A	C	MI.14535	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	844	282	M	L	Ata/Cta	-13.29	0	0	probably_damaging	0.96	neutral	1	neutral	4.4	neutral	1.6	deleterious	-2.72	low_impact	0.91	0.94	neutral	0.86	neutral	1.91	15.66	deleterious	0.27	0.45	0.57	disease	0.69	disease	0.43	neutral	0.23	neutral	5	0.96	neutral	0.52	deleterious	-2	neutral	0.69	deleterious	-2.06	low_impact	1.87	high_impact	-0.38	medium_impact	0.26	0.8	NA	NA	0.25	N	0.37	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5313	5313	A	G	MI.14536	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	844	282	M	V	Ata/Gta	-13.29	0	0	probably_damaging	0.98	neutral	0.34	neutral	4.24	neutral	0.6	deleterious	-3.69	medium_impact	2.72	0.84	neutral	0.15	damaging	2.53	19.69	deleterious	0.22	0.45	0.42	neutral	0.71	disease	0.57	disease	0.54	disease	1	0.99	deleterious	0.18	neutral	1	deleterious	0.73	deleterious	-2.34	low_impact	0.05	medium_impact	1.15	medium_impact	0.31	0.8	NA	NA	0.24	N	0.74	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5313	5313	A	T	MI.14537	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	844	282	M	L	Ata/Tta	-13.29	0	0	probably_damaging	0.96	neutral	1	neutral	4.4	neutral	1.6	deleterious	-2.72	low_impact	0.91	0.94	neutral	0.86	neutral	1.98	16.09	deleterious	0.27	0.45	0.57	disease	0.69	disease	0.43	neutral	0.23	neutral	5	0.96	neutral	0.52	deleterious	-2	neutral	0.69	deleterious	-2.06	low_impact	1.87	high_impact	-0.38	medium_impact	0.26	0.8	NA	NA	0.27	N	0.37	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5314	5314	T	A	MI.14538	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	845	282	M	K	aTa/aAa	1.28	0.57	0	probably_damaging	0.99	neutral	0.24	neutral	4.11	neutral	-2.48	deleterious	-5.68	high_impact	4.22	0.81	neutral	0.12	damaging	3.94	23.50	deleterious	0.04	0.35	0.88	disease	0.88	disease	0.72	disease	0.65	disease	3	0.99	deleterious	0.13	neutral	2	deleterious	0.87	deleterious	-2.62	low_impact	-0.07	medium_impact	2.41	high_impact	0.22	0.8	NA	NA	0.39	N	0.93	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5314	5314	T	C	MI.14539	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	845	282	M	T	aTa/aCa	1.28	0.57	0	probably_damaging	0.99	neutral	0.39	neutral	4.15	neutral	-1.03	deleterious	-5.63	medium_impact	3.07	0.83	neutral	0.16	damaging	2.94	22.00	deleterious	0.09	0.35	0.72	disease	0.77	disease	0.58	disease	0.55	disease	1	0.99	deleterious	0.2	neutral	1	deleterious	0.81	deleterious	-2.62	low_impact	0.1	medium_impact	1.44	medium_impact	0.13	0.8	NA	NA	0.29	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8370	8370	C	T	MI.1454	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	5	2	P	L	cCc/cTc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	-1.23	deleterious	-11.38	deleterious	-9.94	high_impact	3.9	1	neutral	0.38	neutral	4.19	23.90	deleterious	0.42878708	0.85	0.87	disease	0.13	neutral	0.53	disease	0.22	neutral	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	2.25	high_impact	0.63	0.85	22.06	7.2	0.64	P	0.92	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5315	5315	A	C	MI.14540	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	846	282	M	I	atA/atC	4.29	0.77	0.01	probably_damaging	0.98	neutral	0.63	neutral	4.27	neutral	0.67	deleterious	-3.65	medium_impact	2.25	0.85	neutral	0.41	neutral	3.19	22.70	deleterious	0.24	0.45	0.43	neutral	0.31	neutral	0.39	neutral	0.44	neutral	1	0.98	deleterious	0.33	neutral	1	deleterious	0.70	deleterious	-2.34	low_impact	0.34	medium_impact	0.75	medium_impact	0.27	0.8	NA	NA	0.34	N	0.75	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5315	5315	A	T	MI.14541	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	846	282	M	I	atA/atT	4.29	0.77	0.01	probably_damaging	0.98	neutral	0.63	neutral	4.27	neutral	0.67	deleterious	-3.65	medium_impact	2.25	0.85	neutral	0.41	neutral	3.30	22.90	deleterious	0.24	0.45	0.43	neutral	0.31	neutral	0.39	neutral	0.44	neutral	1	0.98	deleterious	0.33	neutral	1	deleterious	0.70	deleterious	-2.34	low_impact	0.34	medium_impact	0.75	medium_impact	0.27	0.8	NA	NA	0.35	N	0.75	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5316	5316	G	C	MI.14542	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	847	283	A	P	Gcc/Ccc	-1.03	0	0	possibly_damaging	0.86	neutral	0.2	neutral	3.94	deleterious	-4.73	deleterious	-4.33	high_impact	3.62	0.77	neutral	0.32	neutral	3.88	23.50	deleterious	0.04	0.35	0.98	disease	0.91	disease	0.7	disease	0.7	disease	4	0.91	neutral	0.17	neutral	1	deleterious	0.79	deleterious	-1.52	low_impact	-0.13	medium_impact	1.9	medium_impact	0.49	0.8	NA	NA	0.38	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5316	5316	G	A	MI.14543	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	847	283	A	T	Gcc/Acc	-1.03	0	0	benign	0.04	neutral	0.39	neutral	3.99	neutral	-2.21	deleterious	-3.09	medium_impact	2.41	0.95	neutral	0.84	neutral	3.18	22.70	deleterious	0.16	0.45	0.92	disease	0.71	disease	0.44	neutral	0.58	disease	2	0.58	neutral	0.68	deleterious	-3	neutral	0.32	neutral	0.47	medium_impact	0.1	medium_impact	0.88	medium_impact	0.42	0.8	NA	NA	0.36	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5316	5316	G	T	MI.14544	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	847	283	A	S	Gcc/Tcc	-1.03	0	0	possibly_damaging	0.45	neutral	0.4	neutral	3.99	neutral	-2.62	deleterious	-2.58	medium_impact	2.79	0.79	neutral	0.72	neutral	3.70	23.30	deleterious	0.23	0.45	0.87	disease	0.54	disease	0.33	neutral	0.47	neutral	1	0.56	neutral	0.48	deleterious	0	NA	0.52	deleterious	-0.72	medium_impact	0.11	medium_impact	1.2	medium_impact	0.28	0.8	NA	NA	0.33	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5317	5317	C	G	MI.14545	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	848	283	A	G	gCc/gGc	1.05	0	0	possibly_damaging	0.54	neutral	0.32	neutral	4.01	neutral	-1.54	deleterious	-3.65	medium_impact	3.48	0.89	neutral	0.58	neutral	4.03	23.60	deleterious	0.2	0.45	0.95	disease	0.79	disease	0.56	disease	0.67	disease	3	0.67	neutral	0.39	neutral	0	NA	0.59	deleterious	-0.86	medium_impact	0.03	medium_impact	1.79	medium_impact	0.49	0.8	NA	NA	0.46	N	0.68	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5317	5317	C	A	MI.14546	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	848	283	A	D	gCc/gAc	1.05	0	0	possibly_damaging	0.74	neutral	0.2	neutral	3.93	deleterious	-5.32	deleterious	-5.22	high_impact	4.17	0.83	neutral	0.35	neutral	4.69	24.60	deleterious	0.03	0.35	0.98	disease	0.91	disease	0.69	disease	0.7	disease	4	0.85	neutral	0.23	neutral	1	deleterious	0.75	deleterious	-1.21	low_impact	-0.13	medium_impact	2.37	high_impact	0.36	0.8	NA	NA	0.4	N	0.93	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5317	5317	C	T	MI.14547	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	848	283	A	V	gCc/gTc	1.05	0	0	benign	0.04	neutral	0.49	neutral	4.16	neutral	-0.27	deleterious	-2.87	low_impact	1.78	0.96	neutral	0.67	neutral	4.44	24.20	deleterious	0.15	0.4	0.91	disease	0.82	disease	0.47	neutral	0.55	disease	1	0.47	neutral	0.73	deleterious	-6	neutral	0.33	neutral	0.47	medium_impact	0.2	medium_impact	0.35	medium_impact	0.43	0.8	NA	NA	0.29	N	0.58	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5319	5319	A	T	MI.14548	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	850	284	T	S	Acc/Tcc	-13.06	0	0.02	benign	0.02	neutral	0.29	neutral	4.19	neutral	-0.72	neutral	-0.95	neutral_impact	0.27	0.9	neutral	0.62	neutral	1.98	16.07	deleterious	0.4	0.5	0.6	disease	0.35	neutral	0.44	neutral	0.6	disease	2	0.7	neutral	0.64	deleterious	-6	neutral	0.18	neutral	0.75	medium_impact	-0.01	medium_impact	-0.92	medium_impact	0.42	0.8	NA	NA	0.43	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5319	5319	A	C	MI.14549	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	850	284	T	P	Acc/Ccc	-13.06	0	0.02	benign	0.12	neutral	0.05	neutral	4.12	deleterious	-3.38	neutral	-1.92	low_impact	1.27	0.85	neutral	0.44	neutral	2.13	17.05	deleterious	0.06	0.35	0.79	disease	0.8	disease	0.58	disease	0.73	disease	5	0.94	neutral	0.47	neutral	-6	neutral	0.34	neutral	-0.01	medium_impact	-0.5	medium_impact	-0.08	medium_impact	0.29	0.8	NA	NA	0.32	N	0.34	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8370	8370	C	G	MI.1455	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	5	2	P	R	cCc/cGc	5.45	1	0	probably_damaging	1	deleterious	0.02	neutral	-1.23	deleterious	-11.45	deleterious	-8.94	high_impact	3.9	1	neutral	0.35	neutral	3.34	22.90	deleterious	0.34743468	0.85	0.88	disease	0.14	neutral	0.59	disease	0.23	neutral	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-0.66	medium_impact	2.25	high_impact	0.29	0.85	22.06	7.2	0.64	P	0.80	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5319	5319	A	G	MI.14550	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	850	284	T	A	Acc/Gcc	-13.06	0	0.02	benign	0	neutral	0.2	neutral	4.23	neutral	0.04	neutral	-0.38	neutral_impact	0.46	0.97	neutral	0.87	neutral	2.10	16.83	deleterious	0.23	0.45	0.49	neutral	0.28	neutral	0.45	neutral	0.4	neutral	2	0.8	neutral	0.6	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	-0.13	medium_impact	-0.76	medium_impact	0.28	0.8	NA	NA	0.38	N	0.24	polymorphism	1	0.01	rs28456039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5320	5320	C	T	MI.14551	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	851	284	T	I	aCc/aTc	-0.34	0	0	benign	0	neutral	0.45	neutral	4.31	neutral	0.71	neutral	2.84	neutral_impact	-1.59	0.97	neutral	0.99	neutral	-0.61	0.12	neutral	0.13	0.4	0.42	neutral	0.26	neutral	0.18	neutral	0.44	neutral	1	0.55	neutral	0.73	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.16	medium_impact	-2.48	low_impact	0.50	0.8	NA	NA	0.35	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5320	5320	C	G	MI.14552	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	851	284	T	S	aCc/aGc	-0.34	0	0	benign	0.02	neutral	0.29	neutral	4.19	neutral	-0.72	neutral	-0.95	neutral_impact	0.27	0.9	neutral	0.62	neutral	1.65	14.14	neutral	0.4	0.5	0.6	disease	0.35	neutral	0.44	neutral	0.6	disease	2	0.7	neutral	0.64	deleterious	-6	neutral	0.18	neutral	0.75	medium_impact	-0.01	medium_impact	-0.92	medium_impact	0.42	0.8	NA	NA	0.43	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5320	5320	C	A	MI.14553	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	851	284	T	N	aCc/aAc	-0.34	0	0	benign	0.12	deleterious	0.04	neutral	4.13	neutral	-2.84	neutral	-1.91	low_impact	1.82	0.83	neutral	0.63	neutral	1.84	15.25	deleterious	0.24	0.45	0.76	disease	0.58	disease	0.46	neutral	0.49	neutral	0	0.96	neutral	0.46	neutral	-2	neutral	0.26	neutral	-0.01	medium_impact	-0.56	medium_impact	0.39	medium_impact	0.52	0.8	NA	NA	0.38	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5322	5322	A	G	MI.14554	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	853	285	I	V	Atc/Gtc	-16.07	0	0	benign	0	neutral	0.51	neutral	4.26	neutral	0.36	neutral	-0.1	neutral_impact	0.22	0.96	neutral	0.72	neutral	0.03	2.93	deleterious	0.4	0.5	0.5	neutral	0.19	neutral	0.33	neutral	0.28	neutral	4	0.48	neutral	0.76	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.22	medium_impact	-0.96	medium_impact	0.34	0.8	1.15	6.87	0.37	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5322	5322	A	T	MI.14555	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	853	285	I	F	Atc/Ttc	-16.07	0	0	benign	0.27	neutral	0.76	neutral	4.18	neutral	-0.85	neutral	-1.34	neutral_impact	-0.2	0.93	neutral	0.77	neutral	1.04	10.86	neutral	0.21	0.45	0.7	disease	0.49	neutral	0.23	neutral	0.49	neutral	0	0.18	neutral	0.75	deleterious	-6	neutral	0.37	neutral	-0.4	medium_impact	0.49	medium_impact	-1.31	low_impact	0.40	0.8	1.15	6.87	0.25	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5322	5322	A	C	MI.14556	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	853	285	I	L	Atc/Ctc	-16.07	0	0	benign	0	neutral	0.91	neutral	4.27	neutral	0.22	neutral	0.84	neutral_impact	-1.67	0.93	neutral	0.94	neutral	-0.74	0.06	neutral	0.24	0.45	0.37	neutral	0.13	neutral	0.14	neutral	0.23	neutral	6	0.07	neutral	0.96	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.77	medium_impact	-2.55	low_impact	0.43	0.8	1.15	6.87	0.4	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5323	5323	T	G	MI.14557	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	854	285	I	S	aTc/aGc	-3.11	0	0	benign	0.14	neutral	0.55	neutral	4.24	neutral	-0.18	neutral	-1.05	neutral_impact	-2.35	0.82	neutral	0.97	neutral	0.50	7.46	deleterious	0.07	0.35	0.76	disease	0.16	neutral	0.24	neutral	0.45	neutral	1	0.35	neutral	0.71	deleterious	-6	neutral	0.20	neutral	-0.08	medium_impact	0.26	medium_impact	-3.12	low_impact	0.22	0.8	1.15	6.87	0.31	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5323	5323	T	A	MI.14558	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	854	285	I	N	aTc/aAc	-3.11	0	0	possibly_damaging	0.55	neutral	0.32	neutral	4.17	neutral	-0.32	neutral	-2.18	neutral_impact	-0.22	0.86	neutral	0.52	neutral	2.75	21.10	deleterious	0.14	0.4	0.7	disease	0.58	disease	0.37	neutral	0.41	neutral	2	0.67	neutral	0.39	neutral	-3	neutral	0.56	deleterious	-0.88	medium_impact	0.03	medium_impact	-1.33	low_impact	0.20	0.8	1.15	6.87	0.29	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5323	5323	T	C	MI.14559	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	854	285	I	T	aTc/aCc	-3.11	0	0	benign	0.14	neutral	0.65	neutral	4.23	neutral	-0.42	neutral	0.17	neutral_impact	-2.22	0.9	neutral	0.96	neutral	-0.69	0.07	neutral	0.19	0.45	0.45	neutral	0.13	neutral	0.23	neutral	0.28	neutral	4	0.24	neutral	0.76	deleterious	-6	neutral	0.22	neutral	-0.08	medium_impact	0.36	medium_impact	-3.01	low_impact	0.35	0.8	1.15	6.87	0.36	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8370	8370	C	A	MI.1456	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	5	2	P	H	cCc/cAc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	-1.23	deleterious	-12.48	deleterious	-8.94	high_impact	3.9	0.95	neutral	0.34	neutral	3.75	23.30	deleterious	0.33487573	0.85	0.93	disease	0.16	neutral	0.6	disease	0.26	neutral	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	2.25	high_impact	0.22	0.85	22.06	7.2	0.63	P	0.84	disease_causing	0.99	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5324	5324	C	G	MI.14560	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	855	285	I	M	atC/atG	0.36	0	0	benign	0.01	neutral	0.27	neutral	4.16	neutral	-0.99	neutral	0.88	neutral_impact	-0.99	0.97	neutral	0.92	neutral	-0.41	0.37	neutral	0.3	0.45	0.55	disease	0.18	neutral	0.17	neutral	0.4	neutral	2	0.72	neutral	0.63	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	-0.03	medium_impact	-1.98	low_impact	0.53	0.8	1.15	6.87	0.46	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5324	5324	C	A	MI.14561	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	855	285	I	M	atC/atA	0.36	0	0	benign	0.01	neutral	0.27	neutral	4.16	neutral	-0.99	neutral	0.88	neutral_impact	-0.99	0.97	neutral	0.92	neutral	0.04	2.95	deleterious	0.3	0.45	0.55	disease	0.18	neutral	0.17	neutral	0.4	neutral	2	0.72	neutral	0.63	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	-0.03	medium_impact	-1.98	low_impact	0.53	0.8	1.15	6.87	0.46	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5325	5325	A	C	MI.14562	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	856	286	T	P	Acc/Ccc	-2.19	0	0	probably_damaging	0.93	neutral	0.19	neutral	4.01	deleterious	-3.87	neutral	-1.9	medium_impact	2.16	0.75	neutral	0.39	neutral	3.13	22.60	deleterious	0.04	0.35	0.73	disease	0.89	disease	0.73	disease	0.75	disease	5	0.96	neutral	0.13	neutral	1	deleterious	0.81	deleterious	-1.83	low_impact	-0.14	medium_impact	0.67	medium_impact	0.28	0.8	NA	NA	0.3	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5325	5325	A	G	MI.14563	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	856	286	T	A	Acc/Gcc	-2.19	0	0	benign	0.04	neutral	0.73	neutral	4.17	neutral	-0.31	neutral	2.04	neutral_impact	-1.54	0.9	neutral	0.96	neutral	-1.04	0.01	neutral	0.21	0.45	0.68	disease	0.07	neutral	0.27	neutral	0.31	neutral	4	0.21	neutral	0.85	deleterious	-6	neutral	0.19	neutral	0.47	medium_impact	0.45	medium_impact	-2.44	low_impact	0.32	0.8	NA	NA	0.29	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5325	5325	A	T	MI.14564	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	856	286	T	S	Acc/Tcc	-2.19	0	0	benign	0.1	neutral	0.57	neutral	4.46	neutral	1.09	neutral	0.13	neutral_impact	-0.88	0.87	neutral	0.95	neutral	0.33	6.03	deleterious	0.39	0.5	0.48	neutral	0.1	neutral	0.34	neutral	0.3	neutral	4	0.34	neutral	0.74	deleterious	-6	neutral	0.22	neutral	0.08	medium_impact	0.28	medium_impact	-1.89	low_impact	0.60	0.8	NA	NA	0.36	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5326	5326	C	A	MI.14565	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	857	286	T	N	aCc/aAc	2.44	0.99	0	possibly_damaging	0.69	neutral	0.34	neutral	4.02	neutral	-2.95	neutral	-2.38	low_impact	1.62	0.83	neutral	0.59	neutral	1.91	15.65	deleterious	0.27	0.45	0.95	disease	0.76	disease	0.62	disease	0.73	disease	5	0.74	neutral	0.33	neutral	-3	neutral	0.75	deleterious	-1.12	low_impact	0.05	medium_impact	0.22	medium_impact	0.45	0.8	NA	NA	0.47	N	0.71	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5326	5326	C	G	MI.14566	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	857	286	T	S	aCc/aGc	2.44	0.99	0	benign	0.1	neutral	0.57	neutral	4.46	neutral	1.09	neutral	0.13	neutral_impact	-0.88	0.87	neutral	0.95	neutral	0.57	7.97	deleterious	0.39	0.5	0.48	neutral	0.1	neutral	0.34	neutral	0.3	neutral	4	0.34	neutral	0.74	deleterious	-6	neutral	0.22	neutral	0.08	medium_impact	0.28	medium_impact	-1.89	low_impact	0.60	0.8	NA	NA	0.43	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5326	5326	C	T	MI.14567	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	857	286	T	I	aCc/aTc	2.44	0.99	0	possibly_damaging	0.87	neutral	0.51	neutral	4.06	neutral	-1.72	neutral	-1.94	medium_impact	2.16	0.86	neutral	0.54	neutral	2.45	19.15	deleterious	0.12	0.4	0.9	disease	0.74	disease	0.59	disease	0.69	disease	4	0.86	neutral	0.32	neutral	0	NA	0.77	deleterious	-1.55	low_impact	0.22	medium_impact	0.67	medium_impact	0.63	0.8	NA	NA	0.44	N	0.70	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5328	5328	C	T	MI.14568	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	859	287	L	F	Ctc/Ttc	-10.98	0	0	probably_damaging	1	neutral	0.29	neutral	3.92	neutral	-2.66	deleterious	-3.83	high_impact	3.67	0.68	neutral	0.04	damaging	4.03	23.60	deleterious	0.19	0.45	0.85	disease	0.68	disease	0.67	disease	0.64	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.01	medium_impact	1.95	medium_impact	0.51	0.8	NA	NA	0.32	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5328	5328	C	G	MI.14569	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	859	287	L	V	Ctc/Gtc	-10.98	0	0	probably_damaging	1	neutral	0.14	neutral	4.2	neutral	0.09	deleterious	-2.87	medium_impact	2.74	0.66	neutral	0.05	damaging	3.50	23.10	deleterious	0.33	0.5	0.39	neutral	0.57	disease	0.57	disease	0.62	disease	2	1	deleterious	0.07	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.23	medium_impact	1.16	medium_impact	0.46	0.8	NA	NA	0.3	N	0.73	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8372	8372	C	A	MI.1457	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	7	3	Q	K	Caa/Aaa	-2.19	0	0	probably_damaging	0.94	deleterious	0	deleterious	-2.65	deleterious	-12.55	deleterious	-3.99	high_impact	3.9	0.84	neutral	0.06	damaging	3.77	23.40	deleterious	0.43104827	0.85	0.59	disease	0.14	neutral	0.46	neutral	0.21	neutral	6	1	deleterious	0.03	neutral	6	deleterious	0.70	deleterious	-1.89	low_impact	-1.4	low_impact	2.25	high_impact	0.43	0.85	23.53	8.05	0.48	N	0.85	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5328	5328	C	A	MI.14570	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	859	287	L	I	Ctc/Atc	-10.98	0	0	probably_damaging	1	neutral	0.24	neutral	4	neutral	-0.99	neutral	-1.92	medium_impact	3.12	0.7	neutral	0.05	damaging	4.14	23.80	deleterious	0.32	0.5	0.39	neutral	0.59	disease	0.65	disease	0.65	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.07	medium_impact	1.48	medium_impact	0.54	0.8	NA	NA	0.35	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5329	5329	T	G	MI.14571	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	860	287	L	R	cTc/cGc	0.82	0.39	0	probably_damaging	1	neutral	0.12	neutral	3.87	deleterious	-4.22	deleterious	-5.74	high_impact	4.71	0.56	damaging	0.05	damaging	4.29	24.00	deleterious	0.02	0.35	0.91	disease	0.87	disease	0.78	disease	0.69	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	-0.27	medium_impact	2.82	high_impact	0.17	0.8	NA	NA	0.66	P	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5329	5329	T	C	MI.14572	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	860	287	L	P	cTc/cCc	0.82	0.39	0	probably_damaging	1	deleterious	0.02	neutral	3.86	deleterious	-4.79	deleterious	-6.7	high_impact	4.71	0.53	damaging	0.04	damaging	4.00	23.60	deleterious	0.03	0.35	0.94	disease	0.77	disease	0.78	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-0.73	medium_impact	2.82	high_impact	0.33	0.8	NA	NA	0.6	P	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5329	5329	T	A	MI.14573	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	860	287	L	H	cTc/cAc	0.82	0.39	0	probably_damaging	1	neutral	0.08	neutral	3.86	deleterious	-4.75	deleterious	-6.7	high_impact	4.71	0.69	neutral	0.04	damaging	4.21	23.90	deleterious	0.05	0.35	0.93	disease	0.77	disease	0.75	disease	0.69	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.38	medium_impact	2.82	high_impact	0.27	0.8	NA	NA	0.62	P	0.97	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5331	5331	C	T	MI.14574	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	862	288	L	F	Ctt/Ttt	-4.04	0	0	possibly_damaging	0.49	neutral	0.39	neutral	4	neutral	-2.13	deleterious	-3.74	medium_impact	2.8	0.87	neutral	0.47	neutral	2.20	17.48	deleterious	0.26	0.45	0.81	disease	0.68	disease	0.55	disease	0.63	disease	3	0.59	neutral	0.45	neutral	0	NA	0.62	deleterious	-0.78	medium_impact	0.1	medium_impact	1.21	medium_impact	0.51	0.8	NA	NA	0.36	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5331	5331	C	A	MI.14575	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	862	288	L	I	Ctt/Att	-4.04	0	0	benign	0.01	neutral	0.48	neutral	4.27	neutral	0.09	neutral	-1.83	low_impact	1.38	0.89	neutral	0.79	neutral	1.17	11.59	neutral	0.3	0.45	0.76	disease	0.5	neutral	0.32	neutral	0.3	neutral	4	0.51	neutral	0.74	deleterious	-6	neutral	0.24	neutral	1.03	medium_impact	0.19	medium_impact	0.02	medium_impact	0.37	0.8	NA	NA	0.28	N	0.83	polymorphism	1	0.04	rs200778062	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5331	5331	C	G	MI.14576	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	862	288	L	V	Ctt/Gtt	-4.04	0	0	benign	0.01	neutral	0.24	neutral	4.11	neutral	-0.64	deleterious	-2.75	medium_impact	2.44	0.93	neutral	0.59	neutral	1.56	13.62	neutral	0.3	0.45	0.7	disease	0.58	disease	0.53	disease	0.58	disease	2	0.75	neutral	0.62	deleterious	-3	neutral	0.25	neutral	1.03	medium_impact	-0.07	medium_impact	0.91	medium_impact	0.48	0.8	NA	NA	0.37	N	0.73	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5332	5332	T	C	MI.14577	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	863	288	L	P	cTt/cCt	-1.26	0	0	possibly_damaging	0.75	neutral	0.07	neutral	3.9	deleterious	-4.94	deleterious	-6.58	medium_impact	2.62	0.88	neutral	0.59	neutral	2.15	17.16	deleterious	0.06	0.35	0.87	disease	0.74	disease	0.71	disease	0.57	disease	1	0.95	neutral	0.16	neutral	0	NA	0.72	deleterious	-1.23	low_impact	-0.42	medium_impact	1.06	medium_impact	0.27	0.8	NA	NA	0.42	N	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5332	5332	T	G	MI.14578	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	863	288	L	R	cTt/cGt	-1.26	0	0	possibly_damaging	0.75	neutral	0.14	neutral	3.9	deleterious	-4.37	deleterious	-5.63	high_impact	4.39	0.87	neutral	0.37	neutral	2.49	19.40	deleterious	0.05	0.35	0.76	disease	0.87	disease	0.75	disease	0.73	disease	5	0.9	neutral	0.2	neutral	1	deleterious	0.73	deleterious	-1.23	low_impact	-0.23	medium_impact	2.55	high_impact	0.19	0.8	NA	NA	0.51	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5332	5332	T	A	MI.14579	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	863	288	L	H	cTt/cAt	-1.26	0	0	possibly_damaging	0.9	neutral	0.18	neutral	3.9	deleterious	-4.89	deleterious	-6.58	high_impact	4.04	0.89	neutral	0.37	neutral	3.85	23.40	deleterious	0.07	0.35	0.86	disease	0.77	disease	0.72	disease	0.69	disease	4	0.94	neutral	0.14	neutral	1	deleterious	0.76	deleterious	-1.67	low_impact	-0.16	medium_impact	2.26	high_impact	0.25	0.8	NA	NA	0.47	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8372	8372	C	G	MI.1458	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	7	3	Q	E	Caa/Gaa	-2.19	0	0	possibly_damaging	0.87	deleterious	0	deleterious	-2.65	deleterious	-12.77	deleterious	-2.99	high_impact	3.9	0.75	neutral	0.08	damaging	2.85	21.60	deleterious	0.45913084	0.85	0.64	disease	0.11	neutral	0.46	neutral	0.22	neutral	6	1	deleterious	0.07	neutral	5	deleterious	0.68	deleterious	-1.54	low_impact	-1.4	low_impact	2.25	high_impact	0.36	0.85	23.53	8.05	0.44	N	0.73	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5334	5334	A	C	MI.14580	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	865	289	N	H	Aac/Cac	-5.89	0	0	probably_damaging	1	neutral	0.54	neutral	4.19	neutral	-1.73	deleterious	-4.63	medium_impact	3.05	0.85	neutral	0.11	damaging	3.17	22.70	deleterious	0.34	0.5	0.39	neutral	0.64	disease	0.71	disease	0.72	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.25	medium_impact	1.42	medium_impact	0.20	0.8	NA	NA	0.21	N	0.86	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5334	5334	A	G	MI.14581	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	865	289	N	D	Aac/Gac	-5.89	0	0	probably_damaging	1	neutral	0.21	neutral	4.21	neutral	-0.98	deleterious	-4.58	high_impact	3.75	0.83	neutral	0.12	damaging	3.89	23.50	deleterious	0.46	0.55	0.71	disease	0.7	disease	0.69	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.11	medium_impact	2.01	high_impact	0.36	0.8	NA	NA	0.32	N	0.91	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5334	5334	A	T	MI.14582	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	865	289	N	Y	Aac/Tac	-5.89	0	0	probably_damaging	1	neutral	1	neutral	4.2	neutral	-1.37	deleterious	-7.4	medium_impact	3.4	0.89	neutral	0.11	damaging	3.80	23.40	deleterious	0.09	0.4	0.72	disease	0.76	disease	0.65	disease	0.69	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.81	deleterious	-3.54	low_impact	1.87	high_impact	1.72	medium_impact	0.18	0.8	NA	NA	0.23	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5335	5335	A	G	MI.14583	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	866	289	N	S	aAc/aGc	2.44	0.91	0	probably_damaging	1	neutral	0.42	neutral	4.55	neutral	2.35	deleterious	-4.38	neutral_impact	0.04	0.84	neutral	0.83	neutral	1.67	14.27	neutral	0.46	0.55	0.52	disease	0.08	neutral	0.37	neutral	0.2	neutral	6	1	deleterious	0.21	neutral	-2	neutral	0.70	deleterious	-3.54	low_impact	0.13	medium_impact	-1.11	low_impact	0.31	0.8	NA	NA	0.43	N	0.60	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5335	5335	A	C	MI.14584	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	866	289	N	T	aAc/aCc	2.44	0.91	0	probably_damaging	1	neutral	0.39	neutral	4.38	neutral	1.4	deleterious	-5.44	low_impact	1.27	0.85	neutral	0.18	damaging	3.44	23.00	deleterious	0.3	0.45	0.7	disease	0.55	disease	0.65	disease	0.61	disease	2	1	deleterious	0.2	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	0.1	medium_impact	-0.08	medium_impact	0.30	0.8	NA	NA	0.33	N	0.87	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5335	5335	A	T	MI.14585	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	866	289	N	I	aAc/aTc	2.44	0.91	0	probably_damaging	1	neutral	0.4	neutral	4.22	neutral	-0.49	deleterious	-8.31	medium_impact	3.19	0.86	neutral	0.12	damaging	3.98	23.60	deleterious	0.12	0.4	0.85	disease	0.8	disease	0.61	disease	0.7	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.11	medium_impact	1.54	medium_impact	0.20	0.8	NA	NA	0.37	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5336	5336	C	A	MI.14586	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	867	289	N	K	aaC/aaA	3.83	0.97	0	probably_damaging	1	neutral	0.3	neutral	4.23	neutral	-0.11	deleterious	-5.49	high_impact	3.75	0.85	neutral	0.11	damaging	4.54	24.30	deleterious	0.34	0.5	0.6	disease	0.76	disease	0.69	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0	medium_impact	2.01	high_impact	0.43	0.8	NA	NA	0.48	N	0.93	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5336	5336	C	G	MI.14587	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	867	289	N	K	aaC/aaG	3.83	0.97	0	probably_damaging	1	neutral	0.3	neutral	4.23	neutral	-0.11	deleterious	-5.49	high_impact	3.75	0.85	neutral	0.11	damaging	4.07	23.70	deleterious	0.34	0.5	0.6	disease	0.76	disease	0.69	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0	medium_impact	2.01	high_impact	0.43	0.8	NA	NA	0.49	N	0.93	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5337	5337	C	G	MI.14588	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	868	290	L	V	Ctc/Gtc	-0.11	0.02	0	probably_damaging	1	neutral	0.2	neutral	-0.79	deleterious	-7.71	deleterious	-2.87	high_impact	4.2	0.78	neutral	0.15	damaging	3.52	23.10	deleterious	0.26	0.45	0.74	disease	0.58	disease	0.7	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	-0.13	medium_impact	2.39	high_impact	0.42	0.8	NA	NA	0.38	N	0.77	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5337	5337	C	T	MI.14589	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	868	290	L	F	Ctc/Ttc	-0.11	0.02	0	probably_damaging	1	neutral	0.38	neutral	-0.81	deleterious	-8.82	deleterious	-3.83	high_impact	4.2	0.94	neutral	0.15	damaging	4.04	23.70	deleterious	0.15	0.4	0.89	disease	0.7	disease	0.7	disease	0.65	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.09	medium_impact	2.39	high_impact	0.37	0.8	NA	NA	0.45	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8373	8373	A	C	MI.1459	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	8	3	Q	P	cAa/cCa	7.3	1	0	probably_damaging	0.96	neutral	0.07	deleterious	-2.66	deleterious	-13.66	deleterious	-5.99	high_impact	3.9	0.88	neutral	0.06	damaging	3.09	22.50	deleterious	0.46398601	0.85	0.83	disease	0.21	neutral	0.44	neutral	0.25	neutral	5	0.99	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-2.07	low_impact	-0.34	medium_impact	2.25	high_impact	0.34	0.85	23.53	8.05	0.6	P	0.90	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5337	5337	C	A	MI.14590	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	868	290	L	I	Ctc/Atc	-0.11	0.02	0	probably_damaging	1	neutral	0.22	neutral	-0.79	deleterious	-7.78	neutral	-1.92	high_impact	4.2	0.85	neutral	0.12	damaging	4.34	24.00	deleterious	0.27	0.45	0.68	disease	0.61	disease	0.69	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	-0.1	medium_impact	2.39	high_impact	0.37	0.8	NA	NA	0.41	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5338	5338	T	C	MI.14591	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	869	290	L	P	cTc/cCc	-0.11	0.02	0	probably_damaging	1	neutral	0.05	neutral	-0.82	deleterious	-12.3	deleterious	-6.7	high_impact	4.2	0.82	neutral	0.12	damaging	3.97	23.60	deleterious	0.03	0.35	0.96	disease	0.75	disease	0.79	disease	0.75	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.5	medium_impact	2.39	high_impact	0.23	0.8	NA	NA	0.4	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5338	5338	T	A	MI.14592	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	869	290	L	H	cTc/cAc	-0.11	0.02	0	probably_damaging	1	neutral	0.12	neutral	-0.83	deleterious	-13.08	deleterious	-6.7	high_impact	4.2	0.84	neutral	0.12	damaging	4.20	23.90	deleterious	0.05	0.35	0.96	disease	0.75	disease	0.77	disease	0.73	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.27	medium_impact	2.39	high_impact	0.21	0.8	NA	NA	0.42	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5338	5338	T	G	MI.14593	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	869	290	L	R	cTc/cGc	-0.11	0.02	0	probably_damaging	1	neutral	0.26	neutral	-0.82	deleterious	-12.11	deleterious	-5.75	high_impact	4.2	0.82	neutral	0.11	damaging	4.29	24.00	deleterious	0.02	0.35	0.95	disease	0.86	disease	0.79	disease	0.71	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	-0.04	medium_impact	2.39	high_impact	0.13	0.8	NA	NA	0.42	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5340	5340	T	G	MI.14594	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	871	291	Y	D	Tac/Gac	-2.42	0	0	probably_damaging	0.97	neutral	0.06	neutral	1.6	deleterious	-6.19	deleterious	-8.86	medium_impact	3.38	0.84	neutral	0.33	neutral	3.99	23.60	deleterious	0.04	0.35	0.82	disease	0.93	disease	0.76	disease	0.73	disease	5	0.99	deleterious	0.05	neutral	1	deleterious	0.85	deleterious	-2.18	low_impact	-0.46	medium_impact	1.7	medium_impact	0.20	0.8	NA	NA	0.43	N	0.97	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5340	5340	T	C	MI.14595	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	871	291	Y	H	Tac/Cac	-2.42	0	0	probably_damaging	0.97	neutral	0.17	neutral	1.6	deleterious	-5.52	deleterious	-4.6	medium_impact	3.38	0.88	neutral	0.41	neutral	3.63	23.20	deleterious	0.16	0.45	0.87	disease	0.83	disease	0.72	disease	0.65	disease	3	0.98	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-2.18	low_impact	-0.17	medium_impact	1.7	medium_impact	0.29	0.8	NA	NA	0.42	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5340	5340	T	A	MI.14596	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	871	291	Y	N	Tac/Aac	-2.42	0	0	probably_damaging	0.97	neutral	0.15	neutral	1.61	deleterious	-5.28	deleterious	-8.08	medium_impact	3.04	0.87	neutral	0.46	neutral	4.07	23.70	deleterious	0.08	0.35	0.49	neutral	0.91	disease	0.67	disease	0.76	disease	5	0.98	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-2.18	low_impact	-0.21	medium_impact	1.42	medium_impact	0.24	0.8	NA	NA	0.42	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5341	5341	A	C	MI.14597	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	872	291	Y	S	tAc/tCc	5.68	0.87	0	probably_damaging	0.95	neutral	0.34	neutral	1.64	deleterious	-3.32	deleterious	-7.9	medium_impact	3.38	0.84	neutral	0.46	neutral	3.79	23.40	deleterious	0.08	0.35	0.51	disease	0.86	disease	0.67	disease	0.74	disease	5	0.96	neutral	0.2	neutral	1	deleterious	0.77	deleterious	-1.97	low_impact	0.05	medium_impact	1.7	medium_impact	0.23	0.8	NA	NA	0.52	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5341	5341	A	G	MI.14598	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	872	291	Y	C	tAc/tGc	5.68	0.87	0	probably_damaging	0.98	neutral	0.07	neutral	1.61	deleterious	-5.36	deleterious	-7.89	medium_impact	3.38	0.9	neutral	0.35	neutral	3.62	23.20	deleterious	0.06	0.35	0.89	disease	0.92	disease	0.68	disease	0.66	disease	3	0.99	deleterious	0.05	neutral	1	deleterious	0.83	deleterious	-2.34	low_impact	-0.42	medium_impact	1.7	medium_impact	0.13	0.8	NA	NA	0.61	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5341	5341	A	T	MI.14599	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	872	291	Y	F	tAc/tTc	5.68	0.87	0	benign	0.08	neutral	1	neutral	2.2	neutral	0.69	deleterious	-2.6	neutral_impact	-0.23	0.87	neutral	0.95	neutral	0.82	9.57	deleterious	0.27	0.45	0.46	neutral	0.16	neutral	0.44	neutral	0.23	neutral	5	0.08	neutral	0.96	deleterious	-6	neutral	0.25	neutral	0.17	medium_impact	1.87	high_impact	-1.34	low_impact	0.32	0.8	NA	NA	0.44	N	0.30	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8595	8595	C	A	MI.146	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	69	23	I	M	atC/atA	4.52	0.99	0.01	possibly_damaging	0.82	neutral	0.17	neutral	4.32	neutral	-1.04	neutral	-1.56	low_impact	0.82	0.88	neutral	0.37	neutral	3.47	23.00	deleterious	0.43	0.65	0.74	disease	0.41	neutral	0.53	disease	0.67	disease	3	0.91	neutral	0.18	neutral	-3	neutral	0.65	deleterious	-1.38	low_impact	-0.1	medium_impact	-0.4	medium_impact	0.70	0.9	19.03	10.37	0.5	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8373	8373	A	T	MI.1460	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	8	3	Q	L	cAa/cTa	7.3	1	0	probably_damaging	0.94	deleterious	0	deleterious	-2.66	deleterious	-13.62	deleterious	-6.98	high_impact	3.9	0.87	neutral	0.06	damaging	3.64	23.20	deleterious	0.36619744	0.85	0.76	disease	0.15	neutral	0.45	neutral	0.22	neutral	6	1	deleterious	0.03	neutral	6	deleterious	0.76	deleterious	-1.89	low_impact	-1.4	low_impact	2.25	high_impact	0.28	0.85	23.53	8.05	0.6	P	0.94	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5343	5343	T	C	MI.14600	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	874	292	F	L	Ttc/Ctc	-3.11	0	0	probably_damaging	1	neutral	0.58	neutral	0	deleterious	-7.09	deleterious	-5.74	high_impact	3.62	0.67	neutral	0.06	damaging	4.28	24.00	deleterious	0.14	0.4	0.37	neutral	0.83	disease	0.7	disease	0.7	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.72	deleterious	-3.54	low_impact	0.29	medium_impact	1.9	medium_impact	0.35	0.8	NA	NA	0.33	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5343	5343	T	A	MI.14601	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	874	292	F	I	Ttc/Atc	-3.11	0	0	probably_damaging	1	neutral	0.31	neutral	-0.01	deleterious	-7.47	deleterious	-5.74	high_impact	4.17	0.61	neutral	0.06	damaging	4.67	24.50	deleterious	0.12	0.4	0.57	disease	0.78	disease	0.72	disease	0.69	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.76	deleterious	-3.54	low_impact	0.02	medium_impact	2.37	high_impact	0.37	0.8	NA	NA	0.36	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5343	5343	T	G	MI.14602	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	874	292	F	V	Ttc/Gtc	-3.11	0	0	probably_damaging	1	neutral	0.33	neutral	-0.01	deleterious	-7.65	deleterious	-6.7	medium_impact	3.48	0.59	damaging	0.06	damaging	4.28	24.00	deleterious	0.1	0.4	0.66	disease	0.83	disease	0.71	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.04	medium_impact	1.79	medium_impact	0.31	0.8	NA	NA	0.27	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5344	5344	T	A	MI.14603	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	875	292	F	Y	tTc/tAc	7.3	1	0	probably_damaging	1	neutral	0.77	neutral	0.19	deleterious	-4.22	deleterious	-2.87	medium_impact	3.2	0.61	neutral	0.06	damaging	4.32	24.00	deleterious	0.15	0.4	0.34	neutral	0.74	disease	0.7	disease	0.68	disease	4	1	deleterious	0.39	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.5	medium_impact	1.55	medium_impact	0.52	0.8	NA	NA	0.52	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5344	5344	T	C	MI.14604	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	875	292	F	S	tTc/tCc	7.3	1	0	probably_damaging	1	neutral	0.23	neutral	-0.03	deleterious	-9.62	deleterious	-7.66	high_impact	4.17	0.51	damaging	0.07	damaging	4.32	24.00	deleterious	0.05	0.35	0.87	disease	0.83	disease	0.71	disease	0.66	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.08	medium_impact	2.37	high_impact	0.37	0.8	NA	NA	0.58	P	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5344	5344	T	G	MI.14605	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	875	292	F	C	tTc/tGc	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	-0.03	deleterious	-10.94	deleterious	-7.66	high_impact	4.17	0.61	neutral	0.05	damaging	4.21	23.90	deleterious	0.05	0.35	0.93	disease	0.82	disease	0.74	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.16	medium_impact	2.37	high_impact	0.26	0.8	NA	NA	0.58	P	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5345	5345	C	G	MI.14606	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	876	292	F	L	ttC/ttG	7.3	1	0	probably_damaging	1	neutral	0.58	neutral	0	deleterious	-7.09	deleterious	-5.74	high_impact	3.62	0.67	neutral	0.06	damaging	4.45	24.20	deleterious	0.14	0.4	0.37	neutral	0.83	disease	0.7	disease	0.7	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.72	deleterious	-3.54	low_impact	0.29	medium_impact	1.9	medium_impact	0.35	0.8	NA	NA	0.51	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5345	5345	C	A	MI.14607	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	876	292	F	L	ttC/ttA	7.3	1	0	probably_damaging	1	neutral	0.58	neutral	0	deleterious	-7.09	deleterious	-5.74	high_impact	3.62	0.67	neutral	0.06	damaging	4.70	24.60	deleterious	0.14	0.4	0.37	neutral	0.83	disease	0.7	disease	0.7	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.72	deleterious	-3.54	low_impact	0.29	medium_impact	1.9	medium_impact	0.35	0.8	NA	NA	0.52	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5346	5346	T	G	MI.14608	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	877	293	Y	D	Tac/Gac	-4.5	0	0	probably_damaging	1	neutral	0.11	deleterious	-2.6	deleterious	-14.46	deleterious	-9.57	high_impact	4.2	0.72	neutral	0.05	damaging	3.96	23.60	deleterious	0.03	0.35	NA	NA	0.9	disease	0.8	disease	0.72	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	-0.3	medium_impact	2.39	high_impact	0.15	0.8	NA	NA	0.41	N	0.96	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5346	5346	T	A	MI.14609	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	877	293	Y	N	Tac/Aac	-4.5	0	0	probably_damaging	1	neutral	0.2	deleterious	-2.6	deleterious	-14.02	deleterious	-8.62	high_impact	4.2	0.66	neutral	0.04	damaging	4.05	23.70	deleterious	0.04	0.35	NA	NA	0.88	disease	0.74	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	-0.13	medium_impact	2.39	high_impact	0.15	0.8	NA	NA	0.39	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8373	8373	A	G	MI.1461	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	8	3	Q	R	cAa/cGa	7.3	1	0	probably_damaging	0.94	deleterious	0	deleterious	-2.65	deleterious	-12.74	deleterious	-3.99	high_impact	3.9	0.83	neutral	0.07	damaging	3.29	22.80	deleterious	0.52918828	0.85	0.64	disease	0.13	neutral	0.48	neutral	0.23	neutral	5	1	deleterious	0.03	neutral	6	deleterious	0.75	deleterious	-1.89	low_impact	-1.4	low_impact	2.25	high_impact	0.34	0.85	23.53	8.05	0.61	P	0.77	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5346	5346	T	C	MI.14610	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	877	293	Y	H	Tac/Cac	-4.5	0	0	probably_damaging	1	neutral	0.29	deleterious	-2.6	deleterious	-12.99	deleterious	-4.79	high_impact	4.2	0.69	neutral	0.04	damaging	3.61	23.20	deleterious	0.06	0.35	NA	NA	0.84	disease	0.79	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	-0.01	medium_impact	2.39	high_impact	0.22	0.8	NA	NA	0.41	N	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5347	5347	A	G	MI.14611	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	878	293	Y	C	tAc/tGc	4.52	1	0	probably_damaging	1	neutral	0.1	deleterious	-2.6	deleterious	-15.07	deleterious	-8.62	high_impact	3.85	0.7	neutral	0.04	damaging	4.12	23.80	deleterious	0.04	0.35	NA	NA	0.88	disease	0.78	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	-0.32	medium_impact	2.1	high_impact	0.20	0.8	NA	NA	0.5	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5347	5347	A	T	MI.14612	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	878	293	Y	F	tAc/tTc	4.52	1	0	probably_damaging	1	neutral	0.5	deleterious	-2.58	deleterious	-10.77	deleterious	-3.83	high_impact	4.2	0.75	neutral	0.04	damaging	4.04	23.70	deleterious	0.12	0.4	NA	NA	0.86	disease	0.7	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	0.21	medium_impact	2.39	high_impact	0.34	0.8	NA	NA	0.55	P	0.80	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5347	5347	A	C	MI.14613	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	878	293	Y	S	tAc/tCc	4.52	1	0	probably_damaging	1	neutral	0.49	deleterious	-2.6	deleterious	-13.86	deleterious	-8.62	high_impact	4.2	0.62	neutral	0.06	damaging	4.27	24.00	deleterious	0.04	0.35	NA	NA	0.87	disease	0.72	disease	0.7	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.89	deleterious	-3.54	low_impact	0.2	medium_impact	2.39	high_impact	0.14	0.8	NA	NA	0.5	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5349	5349	C	G	MI.14614	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	880	294	L	V	Cta/Gta	-4.5	0	0	benign	0.01	neutral	0.47	neutral	0.86	deleterious	-4.46	neutral	-0.94	medium_impact	2.12	0.9	neutral	0.66	neutral	1.43	12.94	neutral	0.19	0.45	0.34	neutral	0.51	disease	0.45	neutral	0.36	neutral	3	0.52	neutral	0.73	deleterious	-3	neutral	0.18	neutral	1.03	medium_impact	0.18	medium_impact	0.64	medium_impact	0.59	0.8	NA	NA	0.35	N	0.08	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5349	5349	C	A	MI.14615	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	880	294	L	M	Cta/Ata	-4.5	0	0	benign	0.04	neutral	0.28	neutral	0.99	deleterious	-3.07	neutral	1.71	neutral_impact	-0.44	0.9	neutral	0.88	neutral	-0.70	0.07	neutral	0.21	0.45	0.5	disease	0.1	neutral	0.36	neutral	0.24	neutral	5	0.7	neutral	0.62	deleterious	-6	neutral	0.20	neutral	0.47	medium_impact	-0.02	medium_impact	-1.52	low_impact	0.44	0.8	NA	NA	0.42	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5350	5350	T	G	MI.14616	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	881	294	L	R	cTa/cGa	0.13	0	0	possibly_damaging	0.68	neutral	0.47	neutral	0.78	deleterious	-8.36	deleterious	-3.19	medium_impact	2.67	0.83	neutral	0.45	neutral	2.61	20.30	deleterious	0.02	0.35	0.87	disease	0.85	disease	0.72	disease	0.63	disease	3	0.67	neutral	0.4	neutral	0	NA	0.78	deleterious	-1.1	low_impact	0.18	medium_impact	1.1	medium_impact	0.19	0.8	NA	NA	0.3	N	0.48	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5350	5350	T	A	MI.14617	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	881	294	L	Q	cTa/cAa	0.13	0	0	possibly_damaging	0.75	neutral	0.19	neutral	0.78	deleterious	-8.41	neutral	-2.47	medium_impact	2.67	0.84	neutral	0.53	neutral	2.50	19.44	deleterious	0.02	0.35	0.88	disease	0.71	disease	0.62	disease	0.63	disease	3	0.86	neutral	0.22	neutral	0	NA	0.75	deleterious	-1.23	low_impact	-0.14	medium_impact	1.1	medium_impact	0.41	0.8	NA	NA	0.38	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5350	5350	T	C	MI.14618	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	881	294	L	P	cTa/cCa	0.13	0	0	possibly_damaging	0.75	neutral	0.14	neutral	0.78	deleterious	-8.81	deleterious	-3.98	medium_impact	2.67	0.78	neutral	0.43	neutral	2.36	18.59	deleterious	0.02	0.35	0.9	disease	0.82	disease	0.73	disease	0.64	disease	3	0.9	neutral	0.2	neutral	0	NA	0.80	deleterious	-1.23	low_impact	-0.23	medium_impact	1.1	medium_impact	0.36	0.8	NA	NA	0.32	N	0.81	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5352	5352	C	G	MI.14619	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	883	295	R	G	Cgc/Ggc	-2.88	0	0	probably_damaging	1	neutral	0.33	neutral	-0.7	deleterious	-10.18	deleterious	-6.7	high_impact	3.85	0.55	damaging	0.04	damaging	4.29	24.00	deleterious	0.03	0.35	0.75	disease	0.79	disease	0.79	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.04	medium_impact	2.1	high_impact	0.20	0.8	NA	NA	0.34	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8374	8374	A	T	MI.1462	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	9	3	Q	H	caA/caT	6.84	1	0	probably_damaging	0.99	deleterious	0.03	deleterious	-2.66	deleterious	-14.21	deleterious	-4.99	high_impact	3.9	0.87	neutral	0.07	damaging	3.42	23.00	deleterious	0.46889253	0.85	0.83	disease	0.13	neutral	0.5	neutral	0.23	neutral	6	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-2.65	low_impact	-0.56	medium_impact	2.25	high_impact	0.52	0.85	23.53	8.05	0.61	P	0.82	disease_causing	0.98	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5352	5352	C	A	MI.14620	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	883	295	R	S	Cgc/Agc	-2.88	0	0	probably_damaging	1	neutral	0.43	neutral	-0.7	deleterious	-9.61	deleterious	-5.74	high_impact	4.19	0.42	damaging	0.03	damaging	4.65	24.50	deleterious	0.03	0.35	0.72	disease	0.81	disease	0.77	disease	0.7	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	0.14	medium_impact	2.38	high_impact	0.23	0.8	NA	NA	0.43	N	0.81	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5352	5352	C	T	MI.14621	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	883	295	R	C	Cgc/Tgc	-2.88	0	0	probably_damaging	1	neutral	0.18	neutral	-0.71	deleterious	-12.38	deleterious	-7.66	high_impact	4.19	0.53	damaging	0.02	damaging	5.08	25.30	deleterious	0.06	0.35	0.8	disease	0.84	disease	0.81	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.16	medium_impact	2.38	high_impact	0.63	0.8	NA	NA	0.36	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5353	5353	G	C	MI.14622	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	884	295	R	P	cGc/cCc	4.29	1	0	probably_damaging	1	neutral	0.21	neutral	-0.7	deleterious	-10.69	deleterious	-6.7	high_impact	4.19	0.57	damaging	0.03	damaging	4.33	24.00	deleterious	0.02	0.35	0.87	disease	0.85	disease	0.87	disease	0.64	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	-0.11	medium_impact	2.38	high_impact	0.11	0.8	NA	NA	0.56	P	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5353	5353	G	T	MI.14623	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	884	295	R	L	cGc/cTc	4.29	1	0	probably_damaging	1	neutral	0.69	neutral	-0.7	deleterious	-9.87	deleterious	-6.7	high_impact	4.19	0.49	damaging	0.03	damaging	4.38	24.10	deleterious	0.04	0.35	0.44	neutral	0.93	disease	0.78	disease	0.73	disease	5	1	deleterious	0.35	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.4	medium_impact	2.38	high_impact	0.12	0.8	NA	NA	0.55	P	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5353	5353	G	A	MI.14624	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	884	295	R	H	cGc/cAc	4.29	1	0	probably_damaging	1	neutral	0.54	neutral	-0.68	deleterious	-8.27	deleterious	-4.79	high_impact	4.19	0.53	damaging	0.03	damaging	4.60	24.40	deleterious	0.09	0.35	0.86	disease	0.81	disease	0.76	disease	0.65	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0.25	medium_impact	2.38	high_impact	0.65	0.8	NA	NA	0.59	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5355	5355	C	A	MI.14625	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	886	296	L	M	Cta/Ata	-4.04	0	0	probably_damaging	1	neutral	0.27	neutral	1.32	deleterious	-3.56	neutral	-1.86	medium_impact	2.75	0.89	neutral	0.22	damaging	3.78	23.40	deleterious	0.22	0.45	0.69	disease	0.42	neutral	0.33	neutral	0.56	disease	1	1	deleterious	0.14	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.03	medium_impact	1.17	medium_impact	0.52	0.8	NA	NA	0.42	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5355	5355	C	G	MI.14626	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	886	296	L	V	Cta/Gta	-4.04	0	0	probably_damaging	1	neutral	0.38	neutral	1.37	neutral	-2.87	deleterious	-2.65	medium_impact	3.31	0.95	neutral	0.17	damaging	3.44	23.00	deleterious	0.17	0.45	0.34	neutral	0.47	neutral	0.52	disease	0.42	neutral	2	1	deleterious	0.19	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	0.09	medium_impact	1.64	medium_impact	0.56	0.8	NA	NA	0.38	N	0.54	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5356	5356	T	C	MI.14627	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	887	296	L	P	cTa/cCa	-1.03	0	0	probably_damaging	1	neutral	0.18	neutral	1.24	deleterious	-7.44	deleterious	-6.59	high_impact	4.11	0.9	neutral	0.12	damaging	4.00	23.60	deleterious	0.02	0.35	0.93	disease	0.76	disease	0.75	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	-0.16	medium_impact	2.32	high_impact	0.35	0.8	NA	NA	0.45	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5356	5356	T	G	MI.14628	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	887	296	L	R	cTa/cGa	-1.03	0	0	probably_damaging	1	neutral	0.21	neutral	1.25	deleterious	-6.95	deleterious	-5.68	high_impact	4.11	0.87	neutral	0.12	damaging	4.25	23.90	deleterious	0.02	0.35	0.91	disease	0.83	disease	0.75	disease	0.64	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	-0.11	medium_impact	2.32	high_impact	0.16	0.8	NA	NA	0.41	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5356	5356	T	A	MI.14629	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	887	296	L	Q	cTa/cAa	-1.03	0	0	probably_damaging	1	neutral	0.17	neutral	1.25	deleterious	-7.07	deleterious	-5.68	high_impact	4.11	0.9	neutral	0.13	damaging	4.18	23.80	deleterious	0.03	0.35	0.92	disease	0.71	disease	0.65	disease	0.66	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.17	medium_impact	2.32	high_impact	0.31	0.8	NA	NA	0.43	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8374	8374	A	C	MI.1463	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	9	3	Q	H	caA/caC	6.84	1	0	probably_damaging	0.99	deleterious	0.03	deleterious	-2.66	deleterious	-14.21	deleterious	-4.99	high_impact	3.9	0.87	neutral	0.07	damaging	3.28	22.80	deleterious	0.46889253	0.85	0.83	disease	0.13	neutral	0.5	neutral	0.23	neutral	6	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-2.65	low_impact	-0.56	medium_impact	2.25	high_impact	0.52	0.85	23.53	8.05	0.61	P	0.82	disease_causing	0.98	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5358	5358	A	C	MI.14630	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	889	297	I	L	Atc/Ctc	-2.88	0	0	benign	0.18	neutral	0.64	neutral	1.97	neutral	-0.42	neutral	-0.8	low_impact	1.58	0.89	neutral	0.48	neutral	3.81	23.40	deleterious	0.18	0.45	0.5	disease	0.49	neutral	0.39	neutral	0.37	neutral	3	0.24	neutral	0.73	deleterious	-6	neutral	0.36	neutral	-0.19	medium_impact	0.35	medium_impact	0.19	medium_impact	0.59	0.8	NA	NA	0.28	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5358	5358	A	T	MI.14631	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	889	297	I	F	Atc/Ttc	-2.88	0	0	possibly_damaging	0.66	neutral	0.68	neutral	1.93	neutral	-1.43	neutral	-2.12	low_impact	1.24	0.88	neutral	0.53	neutral	3.86	23.50	deleterious	0.13	0.4	0.61	disease	0.59	disease	0.58	disease	0.67	disease	3	0.59	neutral	0.51	deleterious	-3	neutral	0.70	deleterious	-1.06	low_impact	0.39	medium_impact	-0.1	medium_impact	0.60	0.8	NA	NA	0.23	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5358	5358	A	G	MI.14632	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	889	297	I	V	Atc/Gtc	-2.88	0	0	benign	0.02	neutral	0.48	neutral	2	neutral	0.01	neutral	0.14	low_impact	1.24	0.96	neutral	0.92	neutral	1.77	14.84	neutral	0.25	0.45	0.54	disease	0.23	neutral	0.22	neutral	0.49	neutral	0	0.5	neutral	0.73	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	0.19	medium_impact	-0.1	medium_impact	0.34	0.8	NA	NA	0.41	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5359	5359	T	A	MI.14633	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	890	297	I	N	aTc/aAc	-0.11	0	0	possibly_damaging	0.66	neutral	0.31	neutral	1.9	deleterious	-3.24	neutral	-2.4	low_impact	1.58	0.85	neutral	0.47	neutral	4.71	24.60	deleterious	0.06	0.35	0.74	disease	0.71	disease	0.51	disease	0.5	disease	0	0.74	neutral	0.33	neutral	-3	neutral	0.73	deleterious	-1.06	low_impact	0.02	medium_impact	0.19	medium_impact	0.29	0.8	NA	NA	0.31	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5359	5359	T	C	MI.14634	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	890	297	I	T	aTc/aCc	-0.11	0	0	benign	0.02	neutral	0.4	neutral	2.13	neutral	1.15	neutral	0.61	neutral_impact	-1.86	0.98	neutral	0.97	neutral	1.08	11.10	neutral	0.1	0.4	0.49	neutral	0.12	neutral	0.25	neutral	0.25	neutral	5	0.59	neutral	0.69	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	0.11	medium_impact	-2.71	low_impact	0.37	0.8	NA	NA	0.45	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5359	5359	T	G	MI.14635	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	890	297	I	S	aTc/aGc	-0.11	0	0	benign	0.37	neutral	0.41	neutral	2.28	neutral	1.94	neutral	-1.17	neutral_impact	-0.57	0.81	neutral	0.95	neutral	3.10	22.50	deleterious	0.05	0.35	0.48	neutral	0.33	neutral	0.29	neutral	0.43	neutral	2	0.52	neutral	0.52	deleterious	-6	neutral	0.48	deleterious	-0.59	medium_impact	0.12	medium_impact	-1.62	low_impact	0.39	0.8	NA	NA	0.35	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5360	5360	C	G	MI.14636	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	891	297	I	M	atC/atG	-0.11	0	0	possibly_damaging	0.86	neutral	0.23	neutral	1.94	neutral	-1.2	neutral	-1.07	neutral_impact	0.78	0.93	neutral	0.88	neutral	2.33	18.36	deleterious	0.2	0.45	0.51	disease	0.33	neutral	0.28	neutral	0.35	neutral	3	0.9	neutral	0.19	neutral	-3	neutral	0.66	deleterious	-1.52	low_impact	-0.08	medium_impact	-0.49	medium_impact	0.70	0.85	NA	NA	0.52	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5360	5360	C	A	MI.14637	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	891	297	I	M	atC/atA	-0.11	0	0	possibly_damaging	0.86	neutral	0.23	neutral	1.94	neutral	-1.2	neutral	-1.07	neutral_impact	0.78	0.93	neutral	0.88	neutral	2.76	21.10	deleterious	0.2	0.45	0.51	disease	0.33	neutral	0.28	neutral	0.35	neutral	3	0.9	neutral	0.19	neutral	-3	neutral	0.66	deleterious	-1.52	low_impact	-0.08	medium_impact	-0.49	medium_impact	0.70	0.85	NA	NA	0.52	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5361	5361	T	G	MI.14638	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	892	298	Y	D	Tac/Gac	-4.04	0	0	probably_damaging	1	neutral	0.11	neutral	0.25	deleterious	-10.93	deleterious	-9.56	high_impact	4.18	0.71	neutral	0.07	damaging	4.01	23.60	deleterious	0.03	0.35	0.91	disease	0.89	disease	0.82	disease	0.64	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.3	medium_impact	2.37	high_impact	0.15	0.8	NA	NA	0.39	N	0.96	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5361	5361	T	C	MI.14639	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	892	298	Y	H	Tac/Cac	-4.04	0	0	probably_damaging	1	neutral	0.3	neutral	0.29	deleterious	-6.43	deleterious	-4.78	medium_impact	3.48	0.78	neutral	0.15	damaging	3.63	23.20	deleterious	0.17	0.45	0.87	disease	0.81	disease	0.77	disease	0.5	disease	0	1	deleterious	0.15	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	0	medium_impact	1.79	medium_impact	0.20	0.8	NA	NA	0.35	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8375	8375	C	A	MI.1464	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	10	4	L	M	Cta/Ata	-0.1	0	0	probably_damaging	1	neutral	0.24	neutral	-0.1	deleterious	-4.98	neutral	-1.99	high_impact	3.9	1	neutral	0.43	neutral	3.77	23.40	deleterious	0.35482158	0.85	0.54	disease	0.11	neutral	0.61	disease	0.19	neutral	6	1	deleterious	0.12	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.01	medium_impact	2.25	high_impact	0.63	0.85	25	8.38	0.59	P	0.61	polymorphism	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5361	5361	T	A	MI.14640	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	892	298	Y	N	Tac/Aac	-4.04	0	0	probably_damaging	1	neutral	0.22	neutral	0.25	deleterious	-9.7	deleterious	-8.61	high_impact	3.83	0.77	neutral	0.06	damaging	4.07	23.70	deleterious	0.08	0.35	0.85	disease	0.87	disease	0.73	disease	0.63	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.1	medium_impact	2.08	high_impact	0.23	0.8	NA	NA	0.34	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5362	5362	A	C	MI.14641	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	893	298	Y	S	tAc/tCc	4.52	1	0	probably_damaging	1	neutral	0.3	neutral	0.27	deleterious	-7.37	deleterious	-8.61	high_impact	3.83	0.73	neutral	0.08	damaging	3.79	23.40	deleterious	0.06	0.35	0.73	disease	0.86	disease	0.75	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	0	medium_impact	2.08	high_impact	0.22	0.8	NA	NA	0.56	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5362	5362	A	G	MI.14642	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	893	298	Y	C	tAc/tGc	4.52	1	0	probably_damaging	1	neutral	0.11	neutral	0.25	deleterious	-11.02	deleterious	-8.61	high_impact	4.18	0.73	neutral	0.06	damaging	3.63	23.20	deleterious	0.05	0.35	0.54	disease	0.87	disease	0.8	disease	0.72	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	-0.3	medium_impact	2.37	high_impact	0.10	0.8	NA	NA	0.55	P	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5362	5362	A	T	MI.14643	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	893	298	Y	F	tAc/tTc	4.52	1	0	probably_damaging	1	neutral	0.51	neutral	0.55	deleterious	-3.35	deleterious	-3.83	medium_impact	3.48	0.83	neutral	0.12	damaging	3.54	23.10	deleterious	0.24	0.45	0.45	neutral	0.84	disease	0.68	disease	0.7	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.22	medium_impact	1.79	medium_impact	0.41	0.8	NA	NA	0.49	N	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5364	5364	T	C	MI.14644	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	895	299	S	P	Tcc/Ccc	-1.96	0	0	possibly_damaging	0.46	neutral	0.21	neutral	1.75	deleterious	-3.85	deleterious	-4.01	medium_impact	2.81	0.86	neutral	0.38	neutral	2.58	19.95	deleterious	0.04	0.35	0.9	disease	0.82	disease	0.65	disease	0.66	disease	3	0.76	neutral	0.38	neutral	0	NA	0.73	deleterious	-0.73	medium_impact	-0.11	medium_impact	1.22	medium_impact	0.35	0.8	NA	NA	0.33	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5364	5364	T	G	MI.14645	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	895	299	S	A	Tcc/Gcc	-1.96	0	0	benign	0	neutral	0.52	neutral	1.93	neutral	-0.45	neutral	-1.84	neutral_impact	0.02	0.93	neutral	0.99	neutral	0.14	4.06	deleterious	0.25	0.45	0.41	neutral	0.11	neutral	0.24	neutral	0.25	neutral	5	0.47	neutral	0.76	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.23	medium_impact	-1.13	low_impact	0.49	0.8	NA	NA	0.43	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5364	5364	T	A	MI.14646	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	895	299	S	T	Tcc/Acc	-1.96	0	0	benign	0.01	neutral	0.4	neutral	1.94	neutral	-0.38	neutral	-1.82	neutral_impact	0.56	0.97	neutral	0.98	neutral	0.67	8.62	deleterious	0.24	0.45	0.7	disease	0.14	neutral	0.23	neutral	0.37	neutral	3	0.59	neutral	0.7	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.11	medium_impact	-0.67	medium_impact	0.59	0.8	NA	NA	0.45	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5365	5365	C	A	MI.14647	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	896	299	S	Y	tCc/tAc	-0.57	0	0	possibly_damaging	0.73	neutral	1	neutral	1.76	deleterious	-3.29	deleterious	-4.9	low_impact	1.36	0.87	neutral	0.74	neutral	3.99	23.60	deleterious	0.05	0.35	0.84	disease	0.45	neutral	0.38	neutral	0.63	disease	3	0.73	neutral	0.64	deleterious	-3	neutral	0.71	deleterious	-1.19	low_impact	1.87	high_impact	0	medium_impact	0.29	0.8	NA	NA	0.28	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5365	5365	C	G	MI.14648	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	896	299	S	C	tCc/tGc	-0.57	0	0	possibly_damaging	0.79	neutral	0.18	neutral	1.74	deleterious	-4.24	deleterious	-3.86	neutral_impact	0.77	0.83	neutral	0.63	neutral	3.51	23.10	deleterious	0.08	0.35	0.85	disease	0.34	neutral	0.33	neutral	0.65	disease	3	0.89	neutral	0.2	neutral	-3	neutral	0.70	deleterious	-1.32	low_impact	-0.16	medium_impact	-0.5	medium_impact	0.34	0.8	NA	NA	0.39	N	0.52	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5365	5365	C	T	MI.14649	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	896	299	S	F	tCc/tTc	-0.57	0	0	possibly_damaging	0.5	neutral	0.71	neutral	1.77	neutral	-2.74	deleterious	-4.89	medium_impact	2.81	0.89	neutral	0.47	neutral	3.98	23.60	deleterious	0.05	0.35	0.76	disease	0.69	disease	0.42	neutral	0.47	neutral	1	0.41	neutral	0.61	deleterious	0	NA	0.68	deleterious	-0.8	medium_impact	0.42	medium_impact	1.22	medium_impact	0.14	0.8	NA	NA	0.31	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8375	8375	C	G	MI.1465	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	10	4	L	V	Cta/Gta	-0.1	0	0	probably_damaging	0.97	neutral	0.05	neutral	-0.24	deleterious	-7.49	deleterious	-2.99	high_impact	3.9	1	neutral	0.5	neutral	3.24	22.80	deleterious	0.51005936	0.85	0.36	neutral	0.1	neutral	0.64	disease	0.19	neutral	6	0.99	deleterious	0.04	neutral	2	deleterious	0.73	deleterious	-2.19	low_impact	-0.43	medium_impact	2.25	high_impact	0.50	0.85	25	8.38	0.62	P	0.46	polymorphism	0.98	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5367	5367	A	C	MI.14650	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	898	300	T	P	Acc/Ccc	-7.28	0	0	possibly_damaging	0.9	neutral	0.2	neutral	1.72	deleterious	-5.01	deleterious	-4.99	high_impact	3.56	0.8	neutral	0.31	neutral	4.10	23.70	deleterious	0.04	0.35	0.79	disease	0.83	disease	0.73	disease	0.72	disease	4	0.94	neutral	0.15	neutral	1	deleterious	0.83	deleterious	-1.67	low_impact	-0.13	medium_impact	1.85	medium_impact	0.45	0.8	NA	NA	0.33	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5367	5367	A	G	MI.14651	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	898	300	T	A	Acc/Gcc	-7.28	0	0	benign	0.34	neutral	0.5	neutral	1.97	neutral	-0.2	deleterious	-3.84	low_impact	1.56	0.87	neutral	0.72	neutral	4.05	23.70	deleterious	0.25	0.45	0.49	neutral	0.21	neutral	0.36	neutral	0.33	neutral	3	0.42	neutral	0.58	deleterious	-6	neutral	0.46	deleterious	-0.53	medium_impact	0.21	medium_impact	0.17	medium_impact	0.45	0.8	NA	NA	0.35	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5367	5367	A	T	MI.14652	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	898	300	T	S	Acc/Tcc	-7.28	0	0	possibly_damaging	0.69	neutral	0.42	neutral	1.87	neutral	-0.92	deleterious	-2.7	low_impact	1.6	0.83	neutral	0.92	neutral	2.33	18.34	deleterious	0.3	0.45	0.48	neutral	0.17	neutral	0.3	neutral	0.28	neutral	4	0.7	neutral	0.37	neutral	-3	neutral	0.62	deleterious	-1.12	low_impact	0.13	medium_impact	0.2	medium_impact	0.69	0.85	NA	NA	0.36	N	0.35	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5368	5368	C	T	MI.14653	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	899	300	T	I	aCc/aTc	-0.8	0	0	benign	0.02	neutral	0.4	neutral	1.82	neutral	-1.56	deleterious	-4.82	medium_impact	2.36	0.86	neutral	0.58	neutral	4.05	23.70	deleterious	0.11	0.4	0.4	neutral	0.58	disease	0.38	neutral	0.21	neutral	6	0.58	neutral	0.69	deleterious	-3	neutral	0.19	neutral	0.75	medium_impact	0.11	medium_impact	0.84	medium_impact	0.62	0.8	NA	NA	0.38	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5368	5368	C	A	MI.14654	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	899	300	T	N	aCc/aAc	-0.8	0	0	possibly_damaging	0.9	neutral	0.31	neutral	1.72	deleterious	-4.7	deleterious	-3.94	high_impact	3.56	0.85	neutral	0.46	neutral	3.83	23.40	deleterious	0.26	0.45	0.79	disease	0.68	disease	0.63	disease	0.7	disease	4	0.92	neutral	0.21	neutral	1	deleterious	0.77	deleterious	-1.67	low_impact	0.02	medium_impact	1.85	medium_impact	0.60	0.8	NA	NA	0.37	N	0.84	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5368	5368	C	G	MI.14655	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	899	300	T	S	aCc/aGc	-0.8	0	0	possibly_damaging	0.69	neutral	0.42	neutral	1.87	neutral	-0.92	deleterious	-2.7	low_impact	1.6	0.83	neutral	0.92	neutral	2.03	16.41	deleterious	0.3	0.45	0.48	neutral	0.17	neutral	0.3	neutral	0.28	neutral	4	0.7	neutral	0.37	neutral	-3	neutral	0.62	deleterious	-1.12	low_impact	0.13	medium_impact	0.2	medium_impact	0.69	0.85	NA	NA	0.37	N	0.35	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5370	5370	T	C	MI.14656	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	901	301	S	P	Tca/Cca	-3.11	0	0	probably_damaging	1	neutral	0.2	neutral	1.82	deleterious	-4.35	deleterious	-4.01	medium_impact	2.68	0.74	neutral	0.33	neutral	4.12	23.80	deleterious	0.06	0.35	0.84	disease	0.87	disease	0.79	disease	0.77	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.90	deleterious	-3.54	low_impact	-0.13	medium_impact	1.11	medium_impact	0.18	0.8	NA	NA	0.33	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5370	5370	T	G	MI.14657	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	901	301	S	A	Tca/Gca	-3.11	0	0	probably_damaging	1	neutral	0.51	neutral	1.98	neutral	-0.13	neutral	-1.72	neutral_impact	0.36	0.9	neutral	0.98	neutral	2.25	17.81	deleterious	0.36	0.5	0.46	neutral	0.22	neutral	0.37	neutral	0.4	neutral	2	0.99	deleterious	0.26	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.22	medium_impact	-0.84	medium_impact	0.36	0.8	NA	NA	0.38	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5370	5370	T	A	MI.14658	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	901	301	S	T	Tca/Aca	-3.11	0	0	probably_damaging	1	neutral	0.4	neutral	2.17	neutral	1.02	neutral	-1.87	neutral_impact	-0.12	0.9	neutral	0.98	neutral	1.90	15.59	deleterious	0.33	0.5	0.55	disease	0.06	neutral	0.26	neutral	0.28	neutral	4	1	deleterious	0.2	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.11	medium_impact	-1.25	low_impact	0.35	0.8	NA	NA	0.47	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5371	5371	C	G	MI.14659	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	902	301	S	W	tCa/tGa	-0.34	0	0	probably_damaging	1	neutral	0.18	neutral	1.81	deleterious	-5.05	deleterious	-5.79	medium_impact	3.02	0.9	neutral	0.4	neutral	4.47	24.20	deleterious	0.07	0.35	0.89	disease	0.85	disease	0.72	disease	0.69	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.16	medium_impact	1.4	medium_impact	0.12	0.8	NA	NA	0.42	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8376	8376	T	C	MI.1466	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	11	4	L	P	cTa/cCa	-1.49	0	0	probably_damaging	1	deleterious	0.02	neutral	-0.27	deleterious	-11.28	deleterious	-6.97	high_impact	3.9	0.99	neutral	0.24	damaging	3.85	23.40	deleterious	0.23790843	0.85	0.71	disease	0.33	neutral	0.62	disease	0.24	neutral	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-0.66	medium_impact	2.25	high_impact	0.39	0.85	25	8.38	0.52	N	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5371	5371	C	T	MI.14660	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	902	301	S	L	tCa/tTa	-0.34	0	0	probably_damaging	1	neutral	0.66	neutral	1.97	neutral	-0.29	deleterious	-4.69	medium_impact	2.68	0.88	neutral	0.49	neutral	4.76	24.70	deleterious	0.11	0.4	0.65	disease	0.78	disease	0.65	disease	0.71	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.37	medium_impact	1.11	medium_impact	0.34	0.8	NA	NA	0.28	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5373	5373	A	C	MI.14661	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	904	302	I	L	Atc/Ctc	-1.26	0	0	benign	0	neutral	1	neutral	2.63	neutral	2.71	neutral	1.66	neutral_impact	-1.74	0.83	neutral	0.88	neutral	-0.68	0.08	neutral	0.25	0.45	0.36	neutral	0.16	neutral	0.22	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	1.87	high_impact	-2.61	low_impact	0.67	0.85	NA	NA	0.3	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5373	5373	A	G	MI.14662	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	904	302	I	V	Atc/Gtc	-1.26	0	0	benign	0.01	neutral	0.5	neutral	1.95	neutral	-0.58	neutral	-0.85	low_impact	1.66	0.9	neutral	0.74	neutral	1.35	12.52	neutral	0.48	0.55	0.49	neutral	0.39	neutral	0.51	disease	0.45	neutral	1	0.49	neutral	0.75	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.21	medium_impact	0.25	medium_impact	0.40	0.8	NA	NA	0.36	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5373	5373	A	T	MI.14663	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	904	302	I	F	Atc/Ttc	-1.26	0	0	benign	0.21	neutral	0.75	neutral	1.88	neutral	-2.53	neutral	-1.9	low_impact	1.51	0.86	neutral	0.49	neutral	2.36	18.59	deleterious	0.21	0.45	0.68	disease	0.76	disease	0.53	disease	0.64	disease	3	0.15	neutral	0.77	deleterious	-6	neutral	0.52	deleterious	-0.27	medium_impact	0.47	medium_impact	0.13	medium_impact	0.62	0.8	NA	NA	0.2	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5374	5374	T	C	MI.14664	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	905	302	I	T	aTc/aCc	0.13	0	0	benign	0.18	neutral	0.61	neutral	1.88	neutral	-2.25	deleterious	-2.84	medium_impact	2.21	0.87	neutral	0.49	neutral	1.96	15.97	deleterious	0.09	0.35	0.44	neutral	0.63	disease	0.62	disease	0.69	disease	4	0.27	neutral	0.72	deleterious	-3	neutral	0.39	neutral	-0.19	medium_impact	0.32	medium_impact	0.72	medium_impact	0.13	0.8	NA	NA	0.23	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5374	5374	T	G	MI.14665	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	905	302	I	S	aTc/aGc	0.13	0	0	benign	0.34	neutral	0.44	neutral	1.89	neutral	-1.97	deleterious	-3.71	low_impact	1.66	0.87	neutral	0.5	neutral	2.83	21.50	deleterious	0.03	0.35	0.34	neutral	0.81	disease	0.64	disease	0.72	disease	4	0.48	neutral	0.55	deleterious	-6	neutral	0.52	deleterious	-0.53	medium_impact	0.15	medium_impact	0.25	medium_impact	0.10	0.8	NA	NA	0.3	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5374	5374	T	A	MI.14666	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	905	302	I	N	aTc/aAc	0.13	0	0	possibly_damaging	0.66	neutral	0.37	neutral	1.86	deleterious	-3.87	deleterious	-4.67	medium_impact	2.21	0.88	neutral	0.46	neutral	4.49	24.30	deleterious	0.08	0.35	0.47	neutral	0.81	disease	0.66	disease	0.73	disease	5	0.7	neutral	0.36	neutral	0	NA	0.69	deleterious	-1.06	low_impact	0.08	medium_impact	0.72	medium_impact	0.10	0.8	NA	NA	0.34	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5375	5375	C	A	MI.14667	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	906	302	I	M	atC/atA	4.52	0.79	0	benign	0.01	neutral	0.3	neutral	2.16	neutral	1.15	neutral	0.26	neutral_impact	0.74	0.95	neutral	0.91	neutral	0.81	9.53	deleterious	0.33	0.5	0.65	disease	0.48	neutral	0.29	neutral	0.44	neutral	1	0.69	neutral	0.65	deleterious	-6	neutral	0.22	neutral	1.03	medium_impact	0	medium_impact	-0.52	medium_impact	0.58	0.8	NA	NA	0.38	N	0.56	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5375	5375	C	G	MI.14668	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	906	302	I	M	atC/atG	4.52	0.79	0	benign	0.01	neutral	0.3	neutral	2.16	neutral	1.15	neutral	0.26	neutral_impact	0.74	0.95	neutral	0.91	neutral	0.39	6.53	deleterious	0.33	0.5	0.65	disease	0.48	neutral	0.29	neutral	0.44	neutral	1	0.69	neutral	0.65	deleterious	-6	neutral	0.22	neutral	1.03	medium_impact	0	medium_impact	-0.52	medium_impact	0.58	0.8	NA	NA	0.38	N	0.56	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5376	5376	A	C	MI.14669	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	907	303	T	P	Aca/Cca	-8.2	0	0	probably_damaging	0.98	neutral	0.23	neutral	1.25	deleterious	-6.72	deleterious	-5.71	high_impact	3.83	0.77	neutral	0.1	damaging	3.61	23.20	deleterious	0.04	0.35	0.41	neutral	0.77	disease	0.73	disease	0.68	disease	4	0.98	deleterious	0.13	neutral	2	deleterious	0.77	deleterious	-2.34	low_impact	-0.08	medium_impact	2.08	high_impact	0.32	0.8	NA	NA	0.32	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8376	8376	T	G	MI.1467	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	11	4	L	R	cTa/cGa	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	-0.27	deleterious	-11.05	deleterious	-5.98	high_impact	3.9	1	neutral	0.29	neutral	4.07	23.70	deleterious	0.26016055	0.85	0.77	disease	0.36	neutral	0.67	disease	0.29	neutral	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	2.25	high_impact	0.30	0.85	25	8.38	0.53	N	0.96	disease_causing	0.56	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5376	5376	A	T	MI.14670	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	907	303	T	S	Aca/Tca	-8.2	0	0	benign	0.37	neutral	0.47	neutral	1.3	deleterious	-4.05	deleterious	-3.78	high_impact	4.17	0.88	neutral	0.27	damaging	3.38	23.00	deleterious	0.4	0.5	0.49	neutral	0.68	disease	0.68	disease	0.65	disease	3	0.46	neutral	0.55	deleterious	-2	neutral	0.51	deleterious	-0.59	medium_impact	0.18	medium_impact	2.37	high_impact	0.50	0.8	NA	NA	0.39	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5376	5376	A	G	MI.14671	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	907	303	T	A	Aca/Gca	-8.2	0	0	possibly_damaging	0.7	neutral	0.5	neutral	1.29	deleterious	-4.46	deleterious	-4.75	high_impact	4.17	0.82	neutral	0.13	damaging	3.61	23.20	deleterious	0.28	0.45	0.54	disease	0.56	disease	0.65	disease	0.63	disease	3	0.68	neutral	0.4	neutral	1	deleterious	0.69	deleterious	-1.13	low_impact	0.21	medium_impact	2.37	high_impact	0.37	0.8	NA	NA	0.35	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5377	5377	C	T	MI.14672	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	908	303	T	M	aCa/aTa	2.9	0.95	0	probably_damaging	0.99	neutral	0.36	neutral	1.31	deleterious	-3.94	deleterious	-5.71	high_impact	3.83	0.83	neutral	0.11	damaging	4.18	23.80	deleterious	0.14	0.4	0.86	disease	0.77	disease	0.73	disease	0.67	disease	3	0.99	deleterious	0.19	neutral	2	deleterious	0.80	deleterious	-2.62	low_impact	0.07	medium_impact	2.08	high_impact	0.56	0.8	NA	NA	0.48	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5377	5377	C	A	MI.14673	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	908	303	T	K	aCa/aAa	2.9	0.95	0	possibly_damaging	0.9	neutral	0.42	neutral	1.26	deleterious	-6.13	deleterious	-5.71	high_impact	4.17	0.83	neutral	0.09	damaging	4.56	24.40	deleterious	0.09	0.35	0.53	disease	0.83	disease	0.77	disease	0.71	disease	4	0.9	neutral	0.26	neutral	1	deleterious	0.80	deleterious	-1.67	low_impact	0.13	medium_impact	2.37	high_impact	0.31	0.8	NA	NA	0.54	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5379	5379	C	G	MI.14674	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	910	304	L	V	Cta/Gta	-15.37	0	0	possibly_damaging	0.54	neutral	0.55	neutral	1.74	neutral	-2.2	neutral	-1.55	low_impact	1.77	0.88	neutral	0.65	neutral	3.51	23.10	deleterious	0.36	0.5	0.48	neutral	0.52	disease	0.23	neutral	0.37	neutral	3	0.5	neutral	0.51	deleterious	-3	neutral	0.62	deleterious	-0.86	medium_impact	0.26	medium_impact	0.35	medium_impact	0.33	0.8	NA	NA	0.28	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5379	5379	C	A	MI.14675	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	910	304	L	M	Cta/Ata	-15.37	0	0	benign	0.15	neutral	0.29	neutral	1.82	neutral	-1.16	neutral	1.11	neutral_impact	0.05	0.89	neutral	0.87	neutral	1.17	11.58	neutral	0.31	0.45	0.47	neutral	0.13	neutral	0.13	neutral	0.28	neutral	4	0.66	neutral	0.57	deleterious	-6	neutral	0.38	neutral	-0.11	medium_impact	-0.01	medium_impact	-1.1	low_impact	0.46	0.8	NA	NA	0.56	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5380	5380	T	G	MI.14676	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	911	304	L	R	cTa/cGa	-0.11	0	0	probably_damaging	0.95	neutral	0.38	neutral	1.67	deleterious	-4.62	deleterious	-3.76	medium_impact	3.1	0.77	neutral	0.4	neutral	4.28	24.00	deleterious	0.09	0.35	0.56	disease	0.85	disease	0.62	disease	0.72	disease	4	0.95	neutral	0.22	neutral	1	deleterious	0.84	deleterious	-1.97	low_impact	0.09	medium_impact	1.47	medium_impact	0.12	0.8	NA	NA	0.28	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5380	5380	T	A	MI.14677	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	911	304	L	Q	cTa/cAa	-0.11	0	0	probably_damaging	0.95	neutral	0.31	neutral	1.67	deleterious	-4.77	deleterious	-3.17	medium_impact	2.55	0.82	neutral	0.52	neutral	4.35	24.10	deleterious	0.1	0.4	0.37	neutral	0.75	disease	0.28	neutral	0.51	disease	0	0.96	neutral	0.18	neutral	1	deleterious	0.76	deleterious	-1.97	low_impact	0.02	medium_impact	1	medium_impact	0.12	0.8	NA	NA	0.34	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5380	5380	T	C	MI.14678	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	911	304	L	P	cTa/cCa	-0.11	0	0	probably_damaging	0.97	neutral	0.24	neutral	1.66	deleterious	-5.2	deleterious	-4.68	medium_impact	2.75	0.7	neutral	0.34	neutral	4.07	23.70	deleterious	0.05	0.35	0.79	disease	0.85	disease	0.54	disease	0.69	disease	4	0.97	neutral	0.14	neutral	1	deleterious	0.88	deleterious	-2.18	low_impact	-0.07	medium_impact	1.17	medium_impact	0.16	0.8	NA	NA	0.3	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5382	5382	C	G	MI.14679	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	913	305	L	V	Ctc/Gtc	-1.96	0	0	possibly_damaging	0.56	neutral	0.51	neutral	1.99	neutral	-0.2	neutral	-1.21	neutral_impact	0	0.88	neutral	0.7	neutral	1.90	15.56	deleterious	0.36	0.5	0.64	disease	0.33	neutral	0.3	neutral	0.6	disease	2	0.54	neutral	0.48	deleterious	-3	neutral	0.62	deleterious	-0.89	medium_impact	0.22	medium_impact	-1.14	low_impact	0.29	0.8	NA	NA	0.35	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8376	8376	T	A	MI.1468	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	11	4	L	Q	cTa/cAa	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	-0.27	deleterious	-10.71	deleterious	-5.98	high_impact	3.9	1	neutral	0.35	neutral	4.09	23.70	deleterious	0.24042424	0.85	0.78	disease	0.33	neutral	0.64	disease	0.24	neutral	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	2.25	high_impact	0.46	0.85	25	8.38	0.55	P	0.91	disease_causing	0.5	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5382	5382	C	T	MI.14680	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	913	305	L	F	Ctc/Ttc	-1.96	0	0	benign	0.04	neutral	0.74	neutral	2.09	neutral	1.29	neutral	4.46	neutral_impact	-3.15	0.91	neutral	0.91	neutral	-0.53	0.19	neutral	0.38	0.5	0.63	disease	0.13	neutral	0.14	neutral	0.37	neutral	3	0.19	neutral	0.85	deleterious	-6	neutral	0.23	neutral	0.47	medium_impact	0.46	medium_impact	-3.8	low_impact	0.38	0.8	NA	NA	0.33	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5382	5382	C	A	MI.14681	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	913	305	L	I	Ctc/Atc	-1.96	0	0	possibly_damaging	0.56	neutral	0.4	neutral	1.99	neutral	-0.22	neutral	-0.25	neutral_impact	0	0.88	neutral	0.56	neutral	2.57	19.91	deleterious	0.35	0.5	0.71	disease	0.32	neutral	0.29	neutral	0.64	disease	3	0.62	neutral	0.42	neutral	-3	neutral	0.61	deleterious	-0.89	medium_impact	0.11	medium_impact	-1.14	low_impact	0.41	0.8	NA	NA	0.41	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5383	5383	T	A	MI.14682	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	914	305	L	H	cTc/cAc	0.59	0.09	0	probably_damaging	0.97	neutral	0.54	neutral	1.97	neutral	-0.82	neutral	-1.72	neutral_impact	-0.55	0.84	neutral	0.65	neutral	4.35	24.10	deleterious	0.12	0.4	0.85	disease	0.46	neutral	0.23	neutral	0.65	disease	3	0.96	neutral	0.29	neutral	-2	neutral	0.81	deleterious	-2.18	low_impact	0.25	medium_impact	-1.61	low_impact	0.13	0.8	NA	NA	0.28	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5383	5383	T	C	MI.14683	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	914	305	L	P	cTc/cCc	0.59	0.09	0	probably_damaging	0.95	neutral	0.25	neutral	2.16	neutral	1.88	deleterious	-4.18	neutral_impact	-2.42	0.86	neutral	0.85	neutral	2.97	22.10	deleterious	0.1	0.4	0.83	disease	0.17	neutral	0.25	neutral	0.55	disease	1	0.96	neutral	0.15	neutral	-2	neutral	0.78	deleterious	-1.97	low_impact	-0.06	medium_impact	-3.18	low_impact	0.18	0.8	NA	NA	0.38	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5383	5383	T	G	MI.14684	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	914	305	L	R	cTc/cGc	0.59	0.09	0	probably_damaging	0.93	neutral	0.35	neutral	1.95	neutral	-1.75	deleterious	-3.24	neutral_impact	0	0.81	neutral	0.48	neutral	4.26	23.90	deleterious	0.09	0.35	0.89	disease	0.77	disease	0.45	neutral	0.67	disease	3	0.93	neutral	0.21	neutral	-2	neutral	0.88	deleterious	-1.83	low_impact	0.06	medium_impact	-1.14	low_impact	0.15	0.8	NA	NA	0.32	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5385	5385	C	A	MI.14685	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	916	306	P	T	Ccc/Acc	-7.74	0	0	probably_damaging	1	neutral	0.41	neutral	1.07	deleterious	-4.42	deleterious	-7.65	high_impact	4.18	0.7	neutral	0.05	damaging	3.83	23.40	deleterious	0.44	0.55	0.53	disease	0.85	disease	0.72	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.12	medium_impact	2.37	high_impact	0.56	0.8	NA	NA	0.34	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5385	5385	C	G	MI.14686	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	916	306	P	A	Ccc/Gcc	-7.74	0	0	probably_damaging	1	neutral	0.51	neutral	1.05	deleterious	-4.9	deleterious	-7.65	high_impact	4.18	0.71	neutral	0.09	damaging	3.23	22.80	deleterious	0.47	0.55	0.64	disease	0.71	disease	0.72	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	0.22	medium_impact	2.37	high_impact	0.58	0.8	NA	NA	0.33	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5385	5385	C	T	MI.14687	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	916	306	P	S	Ccc/Tcc	-7.74	0	0	probably_damaging	1	neutral	0.43	neutral	1.14	deleterious	-3.37	deleterious	-7.65	high_impact	3.63	0.66	neutral	0.06	damaging	4.03	23.60	deleterious	0.38	0.5	0.35	neutral	0.85	disease	0.67	disease	0.71	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	0.14	medium_impact	1.91	medium_impact	0.15	0.8	NA	NA	0.31	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5386	5386	C	T	MI.14688	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	917	306	P	L	cCc/cTc	4.29	0.99	0	probably_damaging	1	neutral	0.66	neutral	1.06	deleterious	-4.7	deleterious	-9.56	medium_impact	3.5	0.7	neutral	0.05	damaging	4.56	24.40	deleterious	0.24	0.45	0.48	neutral	0.88	disease	0.68	disease	0.71	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.37	medium_impact	1.8	medium_impact	0.75	0.85	NA	NA	0.47	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5386	5386	C	A	MI.14689	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	917	306	P	H	cCc/cAc	4.29	0.99	0	probably_damaging	1	neutral	0.53	neutral	1.03	deleterious	-5.82	deleterious	-8.61	high_impact	4.18	0.72	neutral	0.04	damaging	4.18	23.80	deleterious	0.25	0.45	0.81	disease	0.87	disease	0.77	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.24	medium_impact	2.37	high_impact	0.18	0.8	NA	NA	0.59	P	0.71	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8378	8378	A	T	MI.1469	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	13	5	N	Y	Aat/Tat	-0.33	0.25	0	probably_damaging	1	neutral	0.22	neutral	1.69	deleterious	-3.86	deleterious	-5.27	medium_impact	3.04	1	neutral	0.69	neutral	3.62	23.20	deleterious	0.57262910	0.85	0.72	disease	0.21	neutral	0.61	disease	0.18	neutral	6	1	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.02	medium_impact	1.51	medium_impact	0.34	0.85	5.88	7.06	0.53	N	0.66	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5386	5386	C	G	MI.14690	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	917	306	P	R	cCc/cGc	4.29	0.99	0	probably_damaging	1	neutral	0.34	neutral	1.03	deleterious	-5.55	deleterious	-8.61	high_impact	4.18	0.68	neutral	0.05	damaging	3.73	23.30	deleterious	0.16	0.45	0.72	disease	0.9	disease	0.76	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.05	medium_impact	2.37	high_impact	0.29	0.8	NA	NA	0.6	P	0.56	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5388	5388	A	G	MI.14691	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	919	307	M	V	Ata/Gta	-2.88	0	0	benign	0.02	neutral	0.51	neutral	2.03	neutral	1.76	neutral	-0.23	low_impact	0.8	0.95	neutral	0.87	neutral	1.05	10.96	neutral	0.36	0.5	0.38	neutral	0.42	neutral	0.48	neutral	0.47	neutral	1	0.46	neutral	0.75	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.22	medium_impact	-0.47	medium_impact	0.28	0.8	NA	NA	0.36	N	0.45	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5388	5388	A	T	MI.14692	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	919	307	M	L	Ata/Tta	-2.88	0	0	benign	0.02	neutral	0.67	neutral	2.02	neutral	1.53	neutral	-0.6	neutral_impact	-0.09	0.91	neutral	0.58	neutral	1.75	14.68	neutral	0.27	0.45	0.38	neutral	0.41	neutral	0.45	neutral	0.46	neutral	1	0.29	neutral	0.83	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.38	medium_impact	-1.22	low_impact	0.24	0.8	NA	NA	0.32	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5388	5388	A	C	MI.14693	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	919	307	M	L	Ata/Cta	-2.88	0	0	benign	0.02	neutral	0.67	neutral	2.02	neutral	1.53	neutral	-0.6	neutral_impact	-0.09	0.91	neutral	0.58	neutral	1.61	13.91	neutral	0.27	0.45	0.38	neutral	0.41	neutral	0.45	neutral	0.46	neutral	1	0.29	neutral	0.83	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.38	medium_impact	-1.22	low_impact	0.24	0.8	NA	NA	0.32	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5389	5389	T	A	MI.14694	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	920	307	M	K	aTa/aAa	-1.96	0	0	benign	0.05	neutral	0.31	neutral	2.09	neutral	3.3	neutral	0.28	neutral_impact	0.46	0.85	neutral	0.5	neutral	2.23	17.72	deleterious	0.19	0.45	0.84	disease	0.63	disease	0.53	disease	0.59	disease	2	0.66	neutral	0.63	deleterious	-6	neutral	0.32	neutral	0.37	medium_impact	0.02	medium_impact	-0.76	medium_impact	0.18	0.8	NA	NA	0.31	N	0.57	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5389	5389	T	C	MI.14695	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	920	307	M	T	aTa/aCa	-1.96	0	0	benign	0	neutral	0.42	neutral	2.11	neutral	3.6	neutral	3.13	neutral_impact	-1.79	0.97	neutral	0.93	neutral	-1.41	0.00	neutral	0.26	0.45	0.47	neutral	0.29	neutral	0.2	neutral	0.45	neutral	1	0.58	neutral	0.71	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.13	medium_impact	-2.65	low_impact	0.06	0.8	NA	NA	0.33	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5390	5390	A	T	MI.14696	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	921	307	M	I	atA/atT	1.28	0	0.02	benign	0.04	neutral	0.42	neutral	2.03	neutral	1.98	neutral	-0.63	neutral_impact	0.11	0.87	neutral	0.48	neutral	1.79	14.90	neutral	0.28	0.45	0.39	neutral	0.44	neutral	0.46	neutral	0.49	neutral	0	0.55	neutral	0.69	deleterious	-6	neutral	0.22	neutral	0.47	medium_impact	0.13	medium_impact	-1.05	low_impact	0.32	0.8	NA	NA	0.36	N	0.43	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5390	5390	A	C	MI.14697	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	921	307	M	I	atA/atC	1.28	0	0.02	benign	0.04	neutral	0.42	neutral	2.03	neutral	1.98	neutral	-0.63	neutral_impact	0.11	0.87	neutral	0.48	neutral	1.69	14.33	neutral	0.28	0.45	0.39	neutral	0.44	neutral	0.46	neutral	0.49	neutral	0	0.55	neutral	0.69	deleterious	-6	neutral	0.22	neutral	0.47	medium_impact	0.13	medium_impact	-1.05	low_impact	0.32	0.8	NA	NA	0.35	N	0.43	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5391	5391	T	C	MI.14698	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	922	308	S	P	Tct/Cct	-7.28	0	0	benign	0.02	neutral	0.22	neutral	1.91	neutral	-1.18	deleterious	-2.52	neutral_impact	0.36	0.94	neutral	0.95	neutral	2.95	22.10	deleterious	0.2	0.45	0.81	disease	0.7	disease	0.34	neutral	0.53	disease	1	0.77	neutral	0.6	deleterious	-6	neutral	0.30	neutral	0.75	medium_impact	-0.1	medium_impact	-0.84	medium_impact	0.23	0.8	NA	NA	0.35	N	0.69	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5391	5391	T	A	MI.14699	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	922	308	S	T	Tct/Act	-7.28	0	0	benign	0.06	neutral	0.48	neutral	2.13	neutral	0.89	neutral	0.98	neutral_impact	-1.5	0.93	neutral	0.99	neutral	1.21	11.79	neutral	0.56	0.6	0.42	neutral	0.08	neutral	0.23	neutral	0.27	neutral	5	0.46	neutral	0.71	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	0.19	medium_impact	-2.41	low_impact	0.46	0.8	NA	NA	0.4	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8595	8595	C	G	MI.147	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	69	23	I	M	atC/atG	4.52	0.99	0.01	possibly_damaging	0.82	neutral	0.17	neutral	4.32	neutral	-1.04	neutral	-1.56	low_impact	0.82	0.88	neutral	0.37	neutral	2.95	22.10	deleterious	0.43	0.65	0.74	disease	0.41	neutral	0.53	disease	0.67	disease	3	0.91	neutral	0.18	neutral	-3	neutral	0.65	deleterious	-1.38	low_impact	-0.1	medium_impact	-0.4	medium_impact	0.70	0.9	19.03	10.37	0.5	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8378	8378	A	C	MI.1470	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	13	5	N	H	Aat/Cat	-0.33	0.25	0	probably_damaging	1	neutral	0.08	neutral	1.71	neutral	-2.73	deleterious	-2.96	medium_impact	3.04	0.99	neutral	0.55	neutral	2.97	22.10	deleterious	0.62949060	0.85	0.57	disease	0.19	neutral	0.59	disease	0.19	neutral	6	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	-0.31	medium_impact	1.51	medium_impact	0.29	0.85	5.88	7.06	0.52	N	0.33	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5391	5391	T	G	MI.14700	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	922	308	S	A	Tct/Gct	-7.28	0	0	benign	0.34	neutral	0.5	neutral	1.89	neutral	-1.6	neutral	-1.3	neutral_impact	0.74	0.89	neutral	0.85	neutral	2.68	20.70	deleterious	0.49	0.55	0.35	neutral	0.31	neutral	0.47	neutral	0.47	neutral	1	0.42	neutral	0.58	deleterious	-6	neutral	0.44	deleterious	-0.53	medium_impact	0.21	medium_impact	-0.52	medium_impact	0.20	0.8	NA	NA	0.36	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5392	5392	C	A	MI.14701	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	923	308	S	Y	tCt/tAt	-1.03	0	0	probably_damaging	0.93	neutral	1	neutral	1.87	neutral	-2.23	deleterious	-2.89	low_impact	1.43	0.9	neutral	0.55	neutral	4.25	23.90	deleterious	0.23	0.45	0.41	neutral	0.67	disease	0.63	disease	0.7	disease	4	0.93	neutral	0.54	deleterious	-2	neutral	0.71	deleterious	-1.83	low_impact	1.87	high_impact	0.06	medium_impact	0.23	0.8	NA	NA	0.2	N	0.77	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5392	5392	C	G	MI.14702	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	923	308	S	C	tCt/tGt	-1.03	0	0	probably_damaging	0.95	neutral	0.17	neutral	1.83	deleterious	-4.89	neutral	-2.42	medium_impact	1.98	0.79	neutral	0.42	neutral	3.66	23.20	deleterious	0.2	0.45	0.82	disease	0.67	disease	0.59	disease	0.69	disease	4	0.97	neutral	0.11	neutral	1	deleterious	0.75	deleterious	-1.97	low_impact	-0.17	medium_impact	0.52	medium_impact	0.26	0.8	NA	NA	0.29	N	0.52	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5392	5392	C	T	MI.14703	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	923	308	S	F	tCt/tTt	-1.03	0	0	possibly_damaging	0.82	neutral	0.71	neutral	1.85	neutral	-2.91	deleterious	-2.71	low_impact	0.94	0.92	neutral	0.76	neutral	4.23	23.90	deleterious	0.23	0.45	0.53	disease	0.69	disease	0.62	disease	0.7	disease	4	0.78	neutral	0.45	neutral	-3	neutral	0.69	deleterious	-1.4	low_impact	0.42	medium_impact	-0.35	medium_impact	0.10	0.8	NA	NA	0.21	N	0.79	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5394	5394	A	C	MI.14704	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	925	309	N	H	Aac/Cac	-13.06	0	0	probably_damaging	1	neutral	0.54	neutral	1.92	neutral	-2.24	deleterious	-4.68	medium_impact	3.21	0.86	neutral	0.1	damaging	3.23	22.80	deleterious	0.71	0.75	0.65	disease	0.57	disease	0.58	disease	0.65	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.25	medium_impact	1.56	medium_impact	0.09	0.8	0.58	8.67	0.2	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5394	5394	A	G	MI.14705	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	925	309	N	D	Aac/Gac	-13.06	0	0	probably_damaging	1	neutral	0.2	neutral	1.91	deleterious	-3.25	deleterious	-4.64	medium_impact	3.21	0.89	neutral	0.14	damaging	3.97	23.60	deleterious	0.74	0.75	0.75	disease	0.57	disease	0.65	disease	0.67	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.13	medium_impact	1.56	medium_impact	0.31	0.8	0.58	8.67	0.41	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5394	5394	A	T	MI.14706	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	925	309	N	Y	Aac/Tac	-13.06	0	0	probably_damaging	1	neutral	1	neutral	1.93	neutral	-1.84	deleterious	-7.48	medium_impact	3.21	0.9	neutral	0.22	damaging	3.89	23.50	deleterious	0.25	0.45	0.38	neutral	0.7	disease	0.58	disease	0.67	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.73	deleterious	-3.54	low_impact	1.87	high_impact	1.56	medium_impact	0.19	0.8	0.58	8.67	0.23	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5395	5395	A	T	MI.14707	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	926	309	N	I	aAc/aTc	8.45	1	0	probably_damaging	1	neutral	0.41	neutral	2.04	neutral	0.49	deleterious	-8.4	low_impact	1.83	0.87	neutral	0.23	damaging	3.99	23.60	deleterious	0.29	0.45	0.61	disease	0.7	disease	0.43	neutral	0.26	neutral	5	1	deleterious	0.21	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	0.12	medium_impact	0.4	medium_impact	0.26	0.8	0.58	8.67	0.56	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5395	5395	A	C	MI.14708	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	926	309	N	T	aAc/aCc	8.45	1	0	probably_damaging	1	neutral	0.4	neutral	2.1	neutral	1.08	deleterious	-5.53	low_impact	0.84	0.88	neutral	0.33	neutral	2.42	18.93	deleterious	0.61	0.65	0.62	disease	0.18	neutral	0.36	neutral	0.39	neutral	2	1	deleterious	0.2	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.11	medium_impact	-0.44	medium_impact	0.19	0.8	0.58	8.67	0.59	P	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5395	5395	A	G	MI.14709	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	926	309	N	S	aAc/aGc	8.45	1	0	probably_damaging	1	neutral	0.41	neutral	2.2	neutral	1.7	deleterious	-4.5	low_impact	1.57	0.82	neutral	0.77	neutral	2.15	17.17	deleterious	0.7	0.75	0.35	neutral	0.37	neutral	0.4	neutral	0.45	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.68	deleterious	-3.54	low_impact	0.12	medium_impact	0.18	medium_impact	0.25	0.8	0.58	8.67	0.57	P	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8378	8378	A	G	MI.1471	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	13	5	N	D	Aat/Gat	-0.33	0.25	0	probably_damaging	0.97	neutral	0.86	neutral	1.95	neutral	1.96	neutral	1.74	neutral_impact	-0.36	0.96	neutral	0.9	neutral	1.00	10.65	neutral	0.80179446	0.90	0.11	neutral	0.03	neutral	0.37	neutral	0.06	neutral	9	0.97	neutral	0.45	neutral	-2	neutral	0.64	deleterious	-2.19	low_impact	0.74	medium_impact	-1.41	low_impact	0.55	0.85	5.88	7.06	0.31	N	0.13	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5396	5396	C	A	MI.14710	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	927	309	N	K	aaC/aaA	4.52	1	0	probably_damaging	1	neutral	0.3	neutral	1.92	neutral	-2.2	deleterious	-5.56	medium_impact	2.87	0.86	neutral	0.1	damaging	4.56	24.40	deleterious	0.67	0.7	0.63	disease	0.67	disease	0.57	disease	0.67	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0	medium_impact	1.27	medium_impact	0.42	0.8	0.58	8.67	0.48	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5396	5396	C	G	MI.14711	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	927	309	N	K	aaC/aaG	4.52	1	0	probably_damaging	1	neutral	0.3	neutral	1.92	neutral	-2.2	deleterious	-5.56	medium_impact	2.87	0.86	neutral	0.1	damaging	4.08	23.70	deleterious	0.67	0.7	0.63	disease	0.67	disease	0.57	disease	0.67	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0	medium_impact	1.27	medium_impact	0.42	0.8	0.58	8.67	0.49	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5397	5397	A	G	MI.14712	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	928	310	N	D	Aac/Gac	-4.96	0	0	possibly_damaging	0.87	neutral	0.23	neutral	1.82	neutral	-2.75	deleterious	-4.37	medium_impact	3.44	0.88	neutral	0.18	damaging	3.83	23.40	deleterious	0.78	0.8	0.89	disease	0.77	disease	0.68	disease	0.69	disease	4	0.91	neutral	0.18	neutral	0	NA	0.78	deleterious	-1.55	low_impact	-0.08	medium_impact	1.75	medium_impact	0.27	0.8	NA	NA	0.42	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5397	5397	A	T	MI.14713	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	928	310	N	Y	Aac/Tac	-4.96	0	0	probably_damaging	0.99	neutral	1	neutral	1.83	neutral	-2.28	deleterious	-7.07	medium_impact	2.98	0.85	neutral	0.19	damaging	3.62	23.20	deleterious	0.2	0.45	0.75	disease	0.88	disease	0.68	disease	0.71	disease	4	0.99	deleterious	0.51	deleterious	1	deleterious	0.83	deleterious	-2.62	low_impact	1.87	high_impact	1.36	medium_impact	0.28	0.8	NA	NA	0.19	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5397	5397	A	C	MI.14714	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	928	310	N	H	Aac/Cac	-4.96	0	0	probably_damaging	0.99	neutral	0.54	neutral	1.84	neutral	-2.22	deleterious	-4.46	high_impact	3.79	0.89	neutral	0.16	damaging	3.08	22.50	deleterious	0.6	0.65	0.84	disease	0.8	disease	0.61	disease	0.63	disease	3	0.99	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-2.62	low_impact	0.25	medium_impact	2.05	high_impact	0.17	0.8	NA	NA	0.31	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5398	5398	A	T	MI.14715	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	929	310	N	I	aAc/aTc	1.51	0	0	probably_damaging	0.97	neutral	0.42	neutral	1.85	neutral	-1.93	deleterious	-7.85	medium_impact	3.1	0.9	neutral	0.54	neutral	4.04	23.70	deleterious	0.26	0.45	0.53	disease	0.9	disease	0.63	disease	0.58	disease	2	0.97	neutral	0.23	neutral	1	deleterious	0.78	deleterious	-2.18	low_impact	0.13	medium_impact	1.47	medium_impact	0.29	0.8	NA	NA	0.42	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5398	5398	A	C	MI.14716	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	929	310	N	T	aAc/aCc	1.51	0	0	possibly_damaging	0.77	neutral	0.43	neutral	1.99	neutral	-0.05	deleterious	-4.94	low_impact	1.62	0.91	neutral	0.73	neutral	3.45	23.00	deleterious	0.52	0.6	0.6	disease	0.75	disease	0.41	neutral	0.23	neutral	5	0.77	neutral	0.33	neutral	-3	neutral	0.76	deleterious	-1.28	low_impact	0.14	medium_impact	0.22	medium_impact	0.30	0.8	NA	NA	0.35	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5398	5398	A	G	MI.14717	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	929	310	N	S	aAc/aGc	1.51	0	0	benign	0.34	neutral	0.44	neutral	1.93	neutral	-0.58	deleterious	-4.08	medium_impact	2.16	0.92	neutral	0.74	neutral	2.14	17.13	deleterious	0.73	0.75	0.53	disease	0.7	disease	0.44	neutral	0.21	neutral	6	0.48	neutral	0.55	deleterious	-3	neutral	0.58	deleterious	-0.53	medium_impact	0.15	medium_impact	0.67	medium_impact	0.23	0.8	NA	NA	0.37	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5399	5399	C	A	MI.14718	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	930	310	N	K	aaC/aaA	0.59	0	0	possibly_damaging	0.89	neutral	0.33	neutral	1.87	neutral	-1.52	deleterious	-5.23	medium_impact	3.24	0.86	neutral	0.18	damaging	4.60	24.40	deleterious	0.62	0.65	0.8	disease	0.85	disease	0.67	disease	0.69	disease	4	0.9	neutral	0.22	neutral	0	NA	0.82	deleterious	-1.63	low_impact	0.04	medium_impact	1.58	medium_impact	0.45	0.8	NA	NA	0.34	N	0.99	polymorphism	1	0.07	rs28631235	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	5399	5399	C	G	MI.14719	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	930	310	N	K	aaC/aaG	0.59	0	0	possibly_damaging	0.89	neutral	0.33	neutral	1.87	neutral	-1.52	deleterious	-5.23	medium_impact	3.24	0.86	neutral	0.18	damaging	4.09	23.70	deleterious	0.62	0.65	0.8	disease	0.85	disease	0.67	disease	0.69	disease	4	0.9	neutral	0.22	neutral	0	NA	0.82	deleterious	-1.63	low_impact	0.04	medium_impact	1.58	medium_impact	0.45	0.8	NA	NA	0.3	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8379	8379	A	C	MI.1472	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	14	5	N	T	aAt/aCt	3.37	0.99	0	probably_damaging	0.98	neutral	0.07	neutral	1.72	neutral	-2	deleterious	-3.29	medium_impact	3.04	0.99	neutral	0.66	neutral	3.17	22.70	deleterious	0.62949060	0.85	0.46	neutral	0.19	neutral	0.55	disease	0.21	neutral	6	1	deleterious	0.05	neutral	1	deleterious	0.72	deleterious	-2.36	low_impact	-0.34	medium_impact	1.51	medium_impact	0.41	0.85	5.88	7.06	0.67	P	0.32	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5400	5400	G	A	MI.14720	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	931	311	V	M	Gta/Ata	-1.26	0	0	benign	0.04	neutral	0.24	neutral	1.98	neutral	-0.31	neutral	1.56	neutral_impact	-2.02	0.9	neutral	0.89	neutral	1.63	13.99	neutral	0.32	0.5	0.46	neutral	0.13	neutral	0.19	neutral	0.28	neutral	5	0.74	neutral	0.6	deleterious	-6	neutral	0.19	neutral	0.47	medium_impact	-0.07	medium_impact	-2.85	low_impact	0.70	0.85	6.92	8.85	0.52	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5400	5400	G	C	MI.14721	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	931	311	V	L	Gta/Cta	-1.26	0	0	benign	0.06	neutral	0.67	neutral	2.02	neutral	0.32	neutral	0.13	neutral_impact	-0.35	0.85	neutral	0.89	neutral	0.45	7.02	deleterious	0.37	0.5	0.37	neutral	0.29	neutral	0.34	neutral	0.43	neutral	1	0.25	neutral	0.81	deleterious	-6	neutral	0.17	neutral	0.3	medium_impact	0.38	medium_impact	-1.44	low_impact	0.56	0.8	6.92	8.85	0.26	N	0.34	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5400	5400	G	T	MI.14722	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	931	311	V	L	Gta/Tta	-1.26	0	0	benign	0.06	neutral	0.67	neutral	2.02	neutral	0.32	neutral	0.13	neutral_impact	-0.35	0.85	neutral	0.89	neutral	0.57	7.94	deleterious	0.37	0.5	0.37	neutral	0.29	neutral	0.34	neutral	0.43	neutral	1	0.25	neutral	0.81	deleterious	-6	neutral	0.17	neutral	0.3	medium_impact	0.38	medium_impact	-1.44	low_impact	0.56	0.8	6.92	8.85	0.26	N	0.34	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5401	5401	T	G	MI.14723	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	932	311	V	G	gTa/gGa	-0.34	0	0	benign	0.14	neutral	0.33	neutral	1.97	neutral	-0.61	deleterious	-3.37	neutral_impact	-0.82	0.88	neutral	0.57	neutral	2.16	17.28	deleterious	0.09	0.4	0.77	disease	0.39	neutral	0.44	neutral	0.65	disease	3	0.61	neutral	0.6	deleterious	-6	neutral	0.36	neutral	-0.08	medium_impact	0.04	medium_impact	-1.84	low_impact	0.13	0.8	6.92	8.85	0.35	N	0.51	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5401	5401	T	A	MI.14724	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	932	311	V	E	gTa/gAa	-0.34	0	0	benign	0.27	neutral	0.27	neutral	1.92	neutral	-1.94	neutral	-2.46	low_impact	0.9	0.9	neutral	0.53	neutral	3.34	22.90	deleterious	0.07	0.35	0.88	disease	0.68	disease	0.49	neutral	0.63	disease	3	0.67	neutral	0.5	deleterious	-6	neutral	0.58	deleterious	-0.4	medium_impact	-0.03	medium_impact	-0.39	medium_impact	0.21	0.8	6.92	8.85	0.37	N	0.47	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5401	5401	T	C	MI.14725	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	932	311	V	A	gTa/gCa	-0.34	0	0	benign	0	neutral	0.52	neutral	2.04	neutral	0.44	neutral	-1.32	neutral_impact	-0.77	0.93	neutral	0.84	neutral	0.08	3.35	deleterious	0.37	0.5	0.59	disease	0.21	neutral	0.4	neutral	0.46	neutral	1	0.47	neutral	0.76	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	0.23	medium_impact	-1.79	low_impact	0.25	0.8	6.92	8.85	0.33	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5403	5403	A	C	MI.14726	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	934	312	K	Q	Aaa/Caa	-3.34	0	0	probably_damaging	1	neutral	0.3	neutral	1.9	neutral	-1.38	deleterious	-3.8	medium_impact	3.02	0.87	neutral	0.15	damaging	3.60	23.20	deleterious	0.43	0.55	0.66	disease	0.63	disease	0.64	disease	0.61	disease	2	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0	medium_impact	1.4	medium_impact	0.21	0.8	NA	NA	0.33	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5403	5403	A	G	MI.14727	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	934	312	K	E	Aaa/Gaa	-3.34	0	0	probably_damaging	1	neutral	0.28	neutral	1.9	neutral	-1.44	deleterious	-3.81	medium_impact	2.33	0.88	neutral	0.14	damaging	4.15	23.80	deleterious	0.22	0.45	0.59	disease	0.73	disease	0.61	disease	0.61	disease	2	1	deleterious	0.14	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.02	medium_impact	0.82	medium_impact	0.36	0.8	NA	NA	0.32	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5404	5404	A	T	MI.14728	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	935	312	K	M	aAa/aTa	2.9	0.88	0	probably_damaging	1	neutral	0.23	neutral	1.98	neutral	-0.22	deleterious	-5.68	low_impact	0.84	0.86	neutral	0.56	neutral	3.83	23.40	deleterious	0.15	0.4	0.57	disease	0.2	neutral	0.46	neutral	0.46	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	-0.08	medium_impact	-0.44	medium_impact	0.13	0.8	NA	NA	0.41	N	0.45	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5404	5404	A	C	MI.14729	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	935	312	K	T	aAa/aCa	2.9	0.88	0	probably_damaging	1	neutral	0.41	neutral	2.1	neutral	0.73	deleterious	-5.71	low_impact	1.34	0.87	neutral	0.2	damaging	3.54	23.10	deleterious	0.2	0.45	0.54	disease	0.47	neutral	0.39	neutral	0.52	disease	0	1	deleterious	0.21	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	0.12	medium_impact	-0.02	medium_impact	0.12	0.8	NA	NA	0.36	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8379	8379	A	T	MI.1473	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	14	5	N	I	aAt/aTt	3.37	0.99	0	probably_damaging	1	neutral	0.06	neutral	1.69	deleterious	-3.77	deleterious	-5.6	medium_impact	2.49	0.99	neutral	0.58	neutral	3.65	23.20	deleterious	0.49421446	0.85	0.72	disease	0.23	neutral	0.56	disease	0.18	neutral	6	1	deleterious	0.03	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.38	medium_impact	1.04	medium_impact	0.28	0.85	5.88	7.06	0.64	P	0.64	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5405	5405	A	C	MI.14730	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	936	312	K	N	aaA/aaC	2.44	0.88	0	probably_damaging	1	neutral	0.32	neutral	1.88	neutral	-1.81	deleterious	-4.76	medium_impact	2.4	0.87	neutral	0.18	damaging	3.93	23.50	deleterious	0.63	0.7	0.42	neutral	0.59	disease	0.58	disease	0.48	neutral	0	1	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.03	medium_impact	0.88	medium_impact	0.28	0.8	NA	NA	0.4	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5405	5405	A	T	MI.14731	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	936	312	K	N	aaA/aaT	2.44	0.88	0	probably_damaging	1	neutral	0.32	neutral	1.88	neutral	-1.81	deleterious	-4.76	medium_impact	2.4	0.87	neutral	0.18	damaging	3.99	23.60	deleterious	0.63	0.7	0.42	neutral	0.59	disease	0.58	disease	0.48	neutral	0	1	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.03	medium_impact	0.88	medium_impact	0.28	0.8	NA	NA	0.41	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5406	5406	A	C	MI.14732	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	937	313	M	L	Ata/Cta	1.51	0.79	0	benign	0.09	neutral	0.67	neutral	2.03	neutral	0.26	neutral	-1.72	neutral_impact	0.35	0.87	neutral	0.95	neutral	1.74	14.63	neutral	0.36	0.5	0.66	disease	0.31	neutral	0.35	neutral	0.61	disease	2	0.23	neutral	0.79	deleterious	-6	neutral	0.37	neutral	0.12	medium_impact	0.38	medium_impact	-0.85	medium_impact	0.30	0.8	1.73	8.19	0.28	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5406	5406	A	T	MI.14733	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	937	313	M	L	Ata/Tta	1.51	0.79	0	benign	0.09	neutral	0.67	neutral	2.03	neutral	0.26	neutral	-1.72	neutral_impact	0.35	0.87	neutral	0.95	neutral	1.82	15.08	deleterious	0.36	0.5	0.66	disease	0.31	neutral	0.35	neutral	0.61	disease	2	0.23	neutral	0.79	deleterious	-6	neutral	0.37	neutral	0.12	medium_impact	0.38	medium_impact	-0.85	medium_impact	0.30	0.8	1.73	8.19	0.29	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5406	5406	A	G	MI.14734	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	937	313	M	V	Ata/Gta	1.51	0.79	0	benign	0.14	neutral	0.52	neutral	1.93	neutral	-0.98	neutral	-2.23	medium_impact	2.17	0.92	neutral	0.59	neutral	2.64	20.40	deleterious	0.36	0.5	0.67	disease	0.43	neutral	0.53	disease	0.63	disease	3	0.39	neutral	0.69	deleterious	-3	neutral	0.39	neutral	-0.08	medium_impact	0.23	medium_impact	0.68	medium_impact	0.25	0.8	1.73	8.19	0.3	N	0.78	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5407	5407	T	A	MI.14735	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	938	313	M	K	aTa/aAa	-0.57	0.01	0	possibly_damaging	0.8	neutral	0.32	neutral	1.93	neutral	-0.93	deleterious	-4.92	neutral_impact	0.67	0.81	neutral	0.34	neutral	4.19	23.80	deleterious	0.13	0.4	0.58	disease	0.32	neutral	0.56	disease	0.62	disease	2	0.83	neutral	0.26	neutral	-3	neutral	0.69	deleterious	-1.35	low_impact	0.03	medium_impact	-0.58	medium_impact	0.23	0.8	1.73	8.19	0.31	N	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5407	5407	T	C	MI.14736	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	938	313	M	T	aTa/aCa	-0.57	0.01	0	possibly_damaging	0.67	neutral	0.43	neutral	2.05	neutral	0.43	deleterious	-4.33	low_impact	0.98	0.84	neutral	0.82	neutral	1.85	15.27	deleterious	0.19	0.45	0.64	disease	0.43	neutral	0.39	neutral	0.59	disease	2	0.67	neutral	0.38	neutral	-3	neutral	0.67	deleterious	-1.08	low_impact	0.14	medium_impact	-0.32	medium_impact	0.06	0.8	1.73	8.19	0.3	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5408	5408	A	T	MI.14737	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	939	313	M	I	atA/atT	1.98	0.06	0	benign	0.03	neutral	0.43	neutral	1.98	neutral	-0.25	neutral	-2.03	low_impact	1.62	0.9	neutral	0.96	neutral	1.94	15.85	deleterious	0.31	0.45	0.73	disease	0.38	neutral	0.36	neutral	0.64	disease	3	0.55	neutral	0.7	deleterious	-6	neutral	0.24	neutral	0.59	medium_impact	0.14	medium_impact	0.22	medium_impact	0.33	0.8	1.73	8.19	0.43	N	0.57	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5408	5408	A	C	MI.14738	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	939	313	M	I	atA/atC	1.98	0.06	0	benign	0.03	neutral	0.43	neutral	1.98	neutral	-0.25	neutral	-2.03	low_impact	1.62	0.9	neutral	0.96	neutral	1.86	15.37	deleterious	0.31	0.45	0.73	disease	0.38	neutral	0.36	neutral	0.64	disease	3	0.55	neutral	0.7	deleterious	-6	neutral	0.24	neutral	0.59	medium_impact	0.14	medium_impact	0.22	medium_impact	0.33	0.8	1.73	8.19	0.42	N	0.57	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5409	5409	A	G	MI.14739	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	940	314	K	E	Aaa/Gaa	-1.03	0	0	benign	0.34	neutral	0.28	neutral	1.72	neutral	-2.6	deleterious	-3.31	high_impact	3.55	0.91	neutral	0.43	neutral	4.16	23.80	deleterious	0.23	0.45	0.68	disease	0.66	disease	0.51	disease	0.51	disease	0	0.66	neutral	0.47	deleterious	-2	neutral	0.61	deleterious	-0.53	medium_impact	-0.02	medium_impact	1.84	medium_impact	0.52	0.8	7.2	8.29	0.43	N	0.62	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8379	8379	A	G	MI.1474	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	14	5	N	S	aAt/aGt	3.37	0.99	0	probably_damaging	0.97	neutral	0.34	neutral	1.8	neutral	-1.35	neutral	-2.29	medium_impact	2.35	1	neutral	0.64	neutral	2.83	21.50	deleterious	0.74880421	0.85	0.31	neutral	0.13	neutral	0.52	disease	0.18	neutral	6	0.98	neutral	0.19	neutral	1	deleterious	0.68	deleterious	-2.19	low_impact	0.13	medium_impact	0.92	medium_impact	0.29	0.85	5.88	7.06	0.64	P	0.35	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5409	5409	A	C	MI.14740	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	940	314	K	Q	Aaa/Caa	-1.03	0	0	possibly_damaging	0.73	neutral	0.3	neutral	1.72	neutral	-2.49	deleterious	-3.16	low_impact	1.42	0.85	neutral	0.86	neutral	2.27	17.95	deleterious	0.4	0.5	0.72	disease	0.21	neutral	0.3	neutral	0.52	disease	0	0.79	neutral	0.29	neutral	-3	neutral	0.67	deleterious	-1.19	low_impact	0	medium_impact	0.05	medium_impact	0.33	0.8	7.2	8.29	0.42	N	0.26	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5410	5410	A	T	MI.14741	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	941	314	K	M	aAa/aTa	1.28	0	0	probably_damaging	0.93	neutral	0.23	neutral	1.68	deleterious	-4.18	deleterious	-4.48	medium_impact	2.4	0.87	neutral	0.88	neutral	2.91	21.90	deleterious	0.12	0.4	0.48	neutral	0.39	neutral	0.34	neutral	0.42	neutral	2	0.95	neutral	0.15	neutral	1	deleterious	0.71	deleterious	-1.83	low_impact	-0.08	medium_impact	0.88	medium_impact	0.23	0.8	7.2	8.29	0.49	N	0.33	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5410	5410	A	C	MI.14742	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	941	314	K	T	aAa/aCa	1.28	0	0	benign	0.03	neutral	0.4	neutral	1.76	neutral	-1.89	deleterious	-4.69	medium_impact	2.2	0.96	neutral	0.95	neutral	2.58	19.99	deleterious	0.17	0.45	0.63	disease	0.49	neutral	0.33	neutral	0.48	neutral	0	0.58	neutral	0.69	deleterious	-3	neutral	0.27	neutral	0.59	medium_impact	0.11	medium_impact	0.71	medium_impact	0.17	0.8	7.2	8.29	0.4	N	0.17	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5411	5411	A	C	MI.14743	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	942	314	K	N	aaA/aaC	0.13	0	0	benign	0.02	neutral	0.33	neutral	1.8	neutral	-1.35	deleterious	-3.91	medium_impact	2.86	0.88	neutral	0.81	neutral	2.86	21.70	deleterious	0.52	0.6	0.74	disease	0.52	disease	0.35	neutral	0.51	disease	0	0.66	neutral	0.66	deleterious	-3	neutral	0.27	neutral	0.75	medium_impact	0.04	medium_impact	1.26	medium_impact	0.32	0.8	7.2	8.29	0.42	N	0.59	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5411	5411	A	T	MI.14744	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	942	314	K	N	aaA/aaT	0.13	0	0	benign	0.02	neutral	0.33	neutral	1.8	neutral	-1.35	deleterious	-3.91	medium_impact	2.86	0.88	neutral	0.81	neutral	2.87	21.70	deleterious	0.52	0.6	0.74	disease	0.52	disease	0.35	neutral	0.51	disease	0	0.66	neutral	0.66	deleterious	-3	neutral	0.27	neutral	0.75	medium_impact	0.04	medium_impact	1.26	medium_impact	0.32	0.8	7.2	8.29	0.43	N	0.59	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5412	5412	T	C	MI.14745	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	943	315	W	R	Tga/Cga	-1.72	0	0	probably_damaging	1	neutral	0.4	neutral	0.79	deleterious	-6.97	deleterious	-13.39	high_impact	3.83	0.8	neutral	0.13	damaging	3.75	23.30	deleterious	0.06	0.35	0.73	disease	0.87	disease	0.8	disease	0.79	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	0.11	medium_impact	2.08	high_impact	0.03	0.8	NA	NA	0.44	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5412	5412	T	G	MI.14746	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	943	315	W	G	Tga/Gga	-1.72	0	0	probably_damaging	1	neutral	0.33	neutral	0.8	deleterious	-6.33	deleterious	-12.43	high_impact	3.63	0.82	neutral	0.13	damaging	4.06	23.70	deleterious	0.05	0.35	0.73	disease	0.79	disease	0.8	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.04	medium_impact	1.91	medium_impact	0.06	0.8	NA	NA	0.43	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5413	5413	G	T	MI.14747	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	944	315	W	L	tGa/tTa	3.6	0.95	0	probably_damaging	1	neutral	0.72	neutral	0.85	deleterious	-4.69	deleterious	-12.43	high_impact	3.83	0.91	neutral	0.12	damaging	4.39	24.10	deleterious	0.09	0.35	0.62	disease	0.74	disease	0.77	disease	0.76	disease	5	1	deleterious	0.36	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.44	medium_impact	2.08	high_impact	0.06	0.8	NA	NA	0.53	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5413	5413	G	C	MI.14748	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	944	315	W	S	tGa/tCa	3.6	0.95	0	probably_damaging	1	neutral	0.44	neutral	0.82	deleterious	-5.56	deleterious	-13.39	high_impact	3.83	0.92	neutral	0.28	neutral	4.09	23.70	deleterious	0.07	0.35	0.54	disease	0.89	disease	0.77	disease	0.78	disease	6	1	deleterious	0.22	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	0.15	medium_impact	2.08	high_impact	0.05	0.8	NA	NA	0.61	P	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5414	5414	A	C	MI.14749	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	945	315	W	C	tgA/tgC	1.51	0.93	0	probably_damaging	1	neutral	0.18	neutral	0.79	deleterious	-7.54	deleterious	-12.43	high_impact	4.18	0.77	neutral	0.11	damaging	4.15	23.80	deleterious	0.06	0.35	0.67	disease	0.86	disease	0.8	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.16	medium_impact	2.37	high_impact	0.05	0.8	NA	NA	0.53	P	0.96	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8380	8380	T	A	MI.1475	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	15	5	N	K	aaT/aaA	5.45	0.99	0	probably_damaging	0.98	neutral	0.11	neutral	1.76	neutral	-1.33	deleterious	-3.29	medium_impact	3.04	0.99	neutral	0.52	neutral	4.23	23.90	deleterious	0.70300388	0.85	0.37	neutral	0.21	neutral	0.55	disease	0.21	neutral	6	0.99	deleterious	0.07	neutral	1	deleterious	0.74	deleterious	-2.36	low_impact	-0.22	medium_impact	1.51	medium_impact	0.46	0.85	5.88	7.06	0.69	P	0.43	polymorphism	0.98	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5414	5414	A	T	MI.14750	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	945	315	W	C	tgA/tgT	1.51	0.93	0	probably_damaging	1	neutral	0.18	neutral	0.79	deleterious	-7.54	deleterious	-12.43	high_impact	4.18	0.77	neutral	0.11	damaging	4.24	23.90	deleterious	0.06	0.35	0.67	disease	0.86	disease	0.8	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.16	medium_impact	2.37	high_impact	0.05	0.8	NA	NA	0.53	P	0.96	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5415	5415	C	A	MI.14751	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	946	316	Q	K	Cag/Aag	-0.11	0	0	probably_damaging	0.99	neutral	0.3	neutral	2.08	neutral	1.29	neutral	-2.46	low_impact	1.84	0.85	neutral	0.66	neutral	2.85	21.60	deleterious	0.33	0.5	0.58	disease	0.59	disease	0.39	neutral	0.52	disease	0	0.99	deleterious	0.16	neutral	-2	neutral	0.76	deleterious	-2.62	low_impact	0	medium_impact	0.4	medium_impact	0.20	0.8	9.51	8.59	0.32	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5415	5415	C	G	MI.14752	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	946	316	Q	E	Cag/Gag	-0.11	0	0	probably_damaging	0.99	neutral	0.27	neutral	2.02	neutral	0.41	neutral	-2.31	medium_impact	2.82	0.89	neutral	0.41	neutral	3.17	22.70	deleterious	0.37	0.5	0.76	disease	0.51	disease	0.62	disease	0.69	disease	4	0.99	deleterious	0.14	neutral	1	deleterious	0.81	deleterious	-2.62	low_impact	-0.03	medium_impact	1.23	medium_impact	0.44	0.8	9.51	8.59	0.43	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5416	5416	A	T	MI.14753	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	947	316	Q	L	cAg/cTg	-0.11	0	0	probably_damaging	1	neutral	0.75	neutral	1.97	neutral	-0.82	deleterious	-5.5	medium_impact	2.19	0.91	neutral	0.85	neutral	2.56	19.88	deleterious	0.13	0.4	0.37	neutral	0.53	disease	0.5	neutral	0.48	neutral	0	1	deleterious	0.38	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.47	medium_impact	0.7	medium_impact	0.05	0.8	9.51	8.59	0.29	N	0.44	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5416	5416	A	C	MI.14754	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	947	316	Q	P	cAg/cCg	-0.11	0	0	probably_damaging	1	neutral	0.22	neutral	1.98	neutral	-0.73	deleterious	-4.89	medium_impact	2.62	0.93	neutral	0.7	neutral	3.25	22.80	deleterious	0.08	0.35	0.79	disease	0.78	disease	0.63	disease	0.75	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.88	deleterious	-3.54	low_impact	-0.1	medium_impact	1.06	medium_impact	0.20	0.8	9.51	8.59	0.44	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5416	5416	A	G	MI.14755	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	947	316	Q	R	cAg/cGg	-0.11	0	0	probably_damaging	0.99	neutral	0.45	neutral	2.62	neutral	3.83	deleterious	-2.54	neutral_impact	0.28	0.91	neutral	0.88	neutral	1.79	14.93	neutral	0.46	0.55	0.68	disease	0.15	neutral	0.32	neutral	0.34	neutral	3	0.99	deleterious	0.23	neutral	-2	neutral	0.73	deleterious	-2.62	low_impact	0.16	medium_impact	-0.91	medium_impact	0.13	0.8	9.51	8.59	0.44	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5417	5417	G	C	MI.14756	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	948	316	Q	H	caG/caC	0.36	0	0.19	probably_damaging	1	neutral	0.55	neutral	1.99	neutral	-0.24	deleterious	-3.91	low_impact	1.34	0.86	neutral	0.96	neutral	2.20	17.49	deleterious	0.33	0.5	0.68	disease	0.19	neutral	0.34	neutral	0.48	neutral	0	1	deleterious	0.28	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	0.26	medium_impact	-0.02	medium_impact	0.32	0.8	9.51	8.59	0.33	N	0.32	polymorphism	1	0.06	rs386828968	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5417	5417	G	T	MI.14757	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	948	316	Q	H	caG/caT	0.36	0	0.19	probably_damaging	1	neutral	0.55	neutral	1.99	neutral	-0.24	deleterious	-3.91	low_impact	1.34	0.86	neutral	0.96	neutral	2.26	17.88	deleterious	0.33	0.5	0.68	disease	0.19	neutral	0.34	neutral	0.48	neutral	0	1	deleterious	0.28	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	0.26	medium_impact	-0.02	medium_impact	0.32	0.8	9.51	8.59	0.33	N	0.32	polymorphism	1	0.06	rs386828968	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5418	5418	T	A	MI.14758	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	949	317	F	I	Ttt/Att	-6.35	0	0.01	benign	0.07	neutral	0.56	neutral	2.01	neutral	0.2	deleterious	-4.23	medium_impact	1.97	0.85	neutral	0.88	neutral	2.82	21.50	deleterious	0.31	0.45	0.67	disease	0.38	neutral	0.39	neutral	0.63	disease	3	0.37	neutral	0.75	deleterious	-3	neutral	0.22	neutral	0.23	medium_impact	0.27	medium_impact	0.51	medium_impact	0.29	0.8	8.65	9.18	0.28	N	0.41	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5418	5418	T	C	MI.14759	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	949	317	F	L	Ttt/Ctt	-6.35	0	0.01	benign	0	neutral	0.91	neutral	2.21	neutral	1.72	deleterious	-4.04	low_impact	0.86	0.97	neutral	0.96	neutral	0.96	10.44	neutral	0.27	0.45	0.5	neutral	0.3	neutral	0.33	neutral	0.29	neutral	4	0.08	neutral	0.96	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.77	medium_impact	-0.42	medium_impact	0.33	0.8	8.65	9.18	0.24	N	0.25	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8380	8380	T	G	MI.1476	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	15	5	N	K	aaT/aaG	5.45	0.99	0	probably_damaging	0.98	neutral	0.11	neutral	1.76	neutral	-1.33	deleterious	-3.29	medium_impact	3.04	0.99	neutral	0.52	neutral	3.93	23.50	deleterious	0.70300388	0.85	0.37	neutral	0.21	neutral	0.55	disease	0.21	neutral	6	0.99	deleterious	0.07	neutral	1	deleterious	0.74	deleterious	-2.36	low_impact	-0.22	medium_impact	1.51	medium_impact	0.46	0.85	5.88	7.06	0.69	P	0.43	polymorphism	0.98	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5418	5418	T	G	MI.14760	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	949	317	F	V	Ttt/Gtt	-6.35	0	0.01	benign	0.11	neutral	0.52	neutral	1.98	neutral	-0.27	deleterious	-5.05	medium_impact	2.12	0.94	neutral	0.93	neutral	2.35	18.49	deleterious	0.26	0.45	0.6	disease	0.57	disease	0.53	disease	0.5	disease	0	0.39	neutral	0.71	deleterious	-3	neutral	0.23	neutral	0.03	medium_impact	0.23	medium_impact	0.64	medium_impact	0.28	0.8	8.65	9.18	0.31	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5419	5419	T	C	MI.14761	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	950	317	F	S	tTt/tCt	-0.57	0	0	possibly_damaging	0.48	neutral	0.5	neutral	1.95	neutral	-1.01	deleterious	-6.17	medium_impact	3.1	0.89	neutral	0.75	neutral	2.53	19.63	deleterious	0.13	0.4	0.43	neutral	0.65	disease	0.55	disease	0.63	disease	3	0.49	neutral	0.51	deleterious	0	NA	0.39	neutral	-0.77	medium_impact	0.21	medium_impact	1.47	medium_impact	0.13	0.8	8.65	9.18	0.39	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5419	5419	T	A	MI.14762	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	950	317	F	Y	tTt/tAt	-0.57	0	0	benign	0.35	neutral	1	neutral	1.95	neutral	-1.06	neutral	-1.91	medium_impact	2.55	0.88	neutral	0.93	neutral	1.23	11.91	neutral	0.25	0.45	0.35	neutral	0.5	neutral	0.37	neutral	0.47	neutral	1	0.35	neutral	0.83	deleterious	-3	neutral	0.36	neutral	-0.55	medium_impact	1.87	high_impact	1	medium_impact	0.20	0.8	8.65	9.18	0.31	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5419	5419	T	G	MI.14763	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	950	317	F	C	tTt/tGt	-0.57	0	0	possibly_damaging	0.82	neutral	0.19	neutral	1.91	deleterious	-3.35	deleterious	-6.14	medium_impact	2.9	0.87	neutral	0.46	neutral	3.55	23.10	deleterious	0.12	0.4	0.87	disease	0.76	disease	0.56	disease	0.75	disease	5	0.9	neutral	0.19	neutral	0	NA	0.72	deleterious	-1.4	low_impact	-0.14	medium_impact	1.3	medium_impact	0.11	0.8	8.65	9.18	0.38	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5420	5420	T	A	MI.14764	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	951	317	F	L	ttT/ttA	-0.11	0	0	benign	0	neutral	0.91	neutral	2.21	neutral	1.72	deleterious	-4.04	low_impact	0.86	0.97	neutral	0.96	neutral	1.18	11.66	neutral	0.27	0.45	0.5	neutral	0.3	neutral	0.33	neutral	0.29	neutral	4	0.08	neutral	0.96	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.77	medium_impact	-0.42	medium_impact	0.33	0.8	8.65	9.18	0.34	N	0.25	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5420	5420	T	G	MI.14765	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	951	317	F	L	ttT/ttG	-0.11	0	0	benign	0	neutral	0.91	neutral	2.21	neutral	1.72	deleterious	-4.04	low_impact	0.86	0.97	neutral	0.96	neutral	1.10	11.22	neutral	0.27	0.45	0.5	neutral	0.3	neutral	0.33	neutral	0.29	neutral	4	0.08	neutral	0.96	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.77	medium_impact	-0.42	medium_impact	0.33	0.8	8.65	9.18	0.33	N	0.25	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5421	5421	G	A	MI.14766	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	952	318	E	K	Gaa/Aaa	-6.35	0	0	benign	0.15	neutral	0.31	neutral	2.24	neutral	2.2	neutral	-1.74	neutral_impact	-0.67	0.81	neutral	0.83	neutral	2.17	17.34	deleterious	0.26	0.45	0.58	disease	0.18	neutral	0.24	neutral	0.3	neutral	4	0.64	neutral	0.58	deleterious	-6	neutral	0.26	neutral	-0.11	medium_impact	0.02	medium_impact	-1.71	low_impact	0.61	0.8	12.97	9.31	0.37	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5421	5421	G	C	MI.14767	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	952	318	E	Q	Gaa/Caa	-6.35	0	0	possibly_damaging	0.82	neutral	0.3	neutral	2.03	neutral	0.44	neutral	-1.27	neutral_impact	-0.32	0.85	neutral	0.93	neutral	1.64	14.06	neutral	0.57	0.65	0.65	disease	0.18	neutral	0.23	neutral	0.43	neutral	1	0.86	neutral	0.24	neutral	-3	neutral	0.66	deleterious	-1.4	low_impact	0	medium_impact	-1.41	low_impact	0.49	0.8	12.97	9.31	0.38	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5422	5422	A	G	MI.14768	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	953	318	E	G	gAa/gGa	-1.96	0	0	probably_damaging	0.92	neutral	0.33	neutral	1.96	neutral	-1.33	deleterious	-4.47	low_impact	1.15	0.86	neutral	0.82	neutral	3.30	22.90	deleterious	0.25	0.45	0.42	neutral	0.26	neutral	0.46	neutral	0.46	neutral	1	0.93	neutral	0.21	neutral	-2	neutral	0.66	deleterious	-1.77	low_impact	0.04	medium_impact	-0.18	medium_impact	0.31	0.8	12.97	9.31	0.36	N	0.60	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5422	5422	A	C	MI.14769	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	953	318	E	A	gAa/gCa	-1.96	0	0	possibly_damaging	0.82	neutral	0.51	neutral	1.99	neutral	-0.19	deleterious	-3.7	low_impact	1.29	0.9	neutral	0.43	neutral	2.55	19.79	deleterious	0.31	0.5	0.66	disease	0.23	neutral	0.42	neutral	0.56	disease	1	0.8	neutral	0.35	neutral	-3	neutral	0.64	deleterious	-1.4	low_impact	0.22	medium_impact	-0.06	medium_impact	0.36	0.8	12.97	9.31	0.37	N	0.39	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8381	8381	A	G	MI.1477	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	16	6	T	A	Act/Gct	-1.49	0	0	probably_damaging	0.97	neutral	0.07	neutral	1.51	deleterious	-4.04	deleterious	-4.48	medium_impact	2.99	0.99	neutral	0.53	neutral	3.26	22.80	deleterious	0.65309858	0.85	0.38	neutral	0.12	neutral	0.64	disease	0.2	neutral	6	0.99	deleterious	0.05	neutral	1	deleterious	0.69	deleterious	-2.19	low_impact	-0.34	medium_impact	1.47	medium_impact	0.56	0.85	7.35	7.2	0.69	P	0.80	polymorphism	0.94	0.41	.	.	.	.	.	.	.	.	.	A8381G	MIDD / LVNC cardiomyopathy-assoc.	+	-	Reported	2	.	P	P	damaging
chrM	5422	5422	A	T	MI.14770	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	953	318	E	V	gAa/gTa	-1.96	0	0	probably_damaging	0.94	neutral	0.5	neutral	1.97	neutral	-0.68	deleterious	-4.6	low_impact	1.84	0.91	neutral	0.31	neutral	3.30	22.90	deleterious	0.22	0.45	0.56	disease	0.41	neutral	0.52	disease	0.63	disease	3	0.93	neutral	0.28	neutral	-2	neutral	0.72	deleterious	-1.89	low_impact	0.21	medium_impact	0.4	medium_impact	0.40	0.8	12.97	9.31	0.34	N	0.61	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5423	5423	A	T	MI.14771	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	954	318	E	D	gaA/gaT	0.13	0	0	possibly_damaging	0.8	neutral	0.21	neutral	1.97	neutral	-0.91	neutral	-1.96	low_impact	0.8	0.89	neutral	0.82	neutral	2.64	20.40	deleterious	0.42	0.55	0.7	disease	0.25	neutral	0.35	neutral	0.57	disease	1	0.88	neutral	0.21	neutral	-3	neutral	0.66	deleterious	-1.35	low_impact	-0.11	medium_impact	-0.47	medium_impact	0.54	0.8	12.97	9.31	0.56	P	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5423	5423	A	C	MI.14772	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	954	318	E	D	gaA/gaC	0.13	0	0	possibly_damaging	0.8	neutral	0.21	neutral	1.97	neutral	-0.91	neutral	-1.96	low_impact	0.8	0.89	neutral	0.82	neutral	2.55	19.82	deleterious	0.42	0.55	0.7	disease	0.25	neutral	0.35	neutral	0.57	disease	1	0.88	neutral	0.21	neutral	-3	neutral	0.66	deleterious	-1.35	low_impact	-0.11	medium_impact	-0.47	medium_impact	0.54	0.8	12.97	9.31	0.55	P	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5424	5424	C	G	MI.14773	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	955	319	H	D	Cat/Gat	-1.72	0	0	benign	0.03	neutral	0.2	neutral	1.98	neutral	-0.81	neutral	-1.1	low_impact	1.15	0.89	neutral	0.6	neutral	2.00	16.20	deleterious	0.31	0.45	0.83	disease	0.41	neutral	0.57	disease	0.67	disease	3	0.79	neutral	0.59	deleterious	-6	neutral	0.24	neutral	0.59	medium_impact	-0.13	medium_impact	-0.18	medium_impact	0.41	0.8	7.49	7.8	0.44	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5424	5424	C	T	MI.14774	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	955	319	H	Y	Cat/Tat	-1.72	0	0	benign	0	neutral	1	neutral	1.98	neutral	-0.77	neutral	-1.81	low_impact	1.15	0.98	neutral	0.92	neutral	0.59	8.11	deleterious	0.33	0.5	0.56	disease	0.35	neutral	0.37	neutral	0.6	disease	2	0	neutral	1	deleterious	-6	neutral	0.20	neutral	1.95	medium_impact	1.87	high_impact	-0.18	medium_impact	0.33	0.8	7.49	7.8	0.28	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5424	5424	C	A	MI.14775	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	955	319	H	N	Cat/Aat	-1.72	0	0	benign	0	neutral	0.33	neutral	2.07	neutral	1.16	neutral	1.43	neutral_impact	-1.1	0.97	neutral	0.97	neutral	-0.42	0.35	neutral	0.47	0.55	0.59	disease	0.17	neutral	0.31	neutral	0.28	neutral	4	0.67	neutral	0.67	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.04	medium_impact	-2.07	low_impact	0.33	0.8	7.49	7.8	0.32	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5425	5425	A	G	MI.14776	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	956	319	H	R	cAt/cGt	-1.96	0	0	benign	0.04	neutral	0.34	neutral	2	neutral	-0.02	neutral	-1.33	neutral_impact	-0.02	0.91	neutral	0.66	neutral	0.98	10.57	neutral	0.33	0.5	0.72	disease	0.42	neutral	0.49	neutral	0.65	disease	3	0.63	neutral	0.65	deleterious	-6	neutral	0.25	neutral	0.47	medium_impact	0.05	medium_impact	-1.16	low_impact	0.12	0.8	7.49	7.8	0.39	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5425	5425	A	C	MI.14777	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	956	319	H	P	cAt/cCt	-1.96	0	0	benign	0.13	neutral	0.21	neutral	2.13	neutral	1.79	neutral	-2.35	neutral_impact	-0.78	0.87	neutral	0.95	neutral	-0.25	0.88	neutral	0.23	0.45	0.66	disease	0.52	disease	0.4	neutral	0.49	neutral	0	0.76	neutral	0.54	deleterious	-6	neutral	0.33	neutral	-0.04	medium_impact	-0.11	medium_impact	-1.8	low_impact	0.29	0.8	7.49	7.8	0.36	N	0.35	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5425	5425	A	T	MI.14778	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	956	319	H	L	cAt/cTt	-1.96	0	0	benign	0.03	neutral	0.66	neutral	2.05	neutral	0.99	deleterious	-2.98	neutral_impact	0.4	0.92	neutral	0.79	neutral	0.66	8.58	deleterious	0.31	0.45	0.65	disease	0.35	neutral	0.49	neutral	0.61	disease	2	0.29	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.59	medium_impact	0.37	medium_impact	-0.81	medium_impact	0.12	0.8	7.49	7.8	0.29	N	0.30	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5426	5426	T	A	MI.14779	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	957	319	H	Q	caT/caA	-1.96	0	0.02	benign	0.1	neutral	0.29	neutral	2.01	neutral	0.3	neutral	-0.88	neutral_impact	0.26	0.96	neutral	0.89	neutral	0.48	7.29	deleterious	0.39	0.5	0.74	disease	0.23	neutral	0.37	neutral	0.57	disease	1	0.67	neutral	0.6	deleterious	-6	neutral	0.24	neutral	0.08	medium_impact	-0.01	medium_impact	-0.93	medium_impact	0.59	0.8	7.49	7.8	0.44	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8381	8381	A	T	MI.1478	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	16	6	T	S	Act/Tct	-1.49	0	0	probably_damaging	0.97	neutral	0.08	neutral	1.5	deleterious	-4.36	deleterious	-3.66	medium_impact	2.99	0.99	neutral	0.46	neutral	3.05	22.40	deleterious	0.57868449	0.85	0.46	neutral	0.13	neutral	0.63	disease	0.21	neutral	6	0.99	deleterious	0.06	neutral	1	deleterious	0.71	deleterious	-2.19	low_impact	-0.31	medium_impact	1.47	medium_impact	0.62	0.85	7.35	7.2	0.61	P	0.77	polymorphism	0.98	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5426	5426	T	G	MI.14780	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	957	319	H	Q	caT/caG	-1.96	0	0.02	benign	0.1	neutral	0.29	neutral	2.01	neutral	0.3	neutral	-0.88	neutral_impact	0.26	0.96	neutral	0.89	neutral	0.37	6.39	deleterious	0.39	0.5	0.74	disease	0.23	neutral	0.37	neutral	0.57	disease	1	0.67	neutral	0.6	deleterious	-6	neutral	0.24	neutral	0.08	medium_impact	-0.01	medium_impact	-0.93	medium_impact	0.59	0.8	7.49	7.8	0.43	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5427	5427	A	T	MI.14781	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	958	320	T	S	Aca/Tca	-6.58	0	0	benign	0.24	neutral	0.48	neutral	1.95	neutral	-0.57	neutral	-2.04	low_impact	1.79	0.8	neutral	0.97	neutral	0.26	5.30	deleterious	0.55	0.6	0.56	disease	0.18	neutral	0.28	neutral	0.32	neutral	4	0.42	neutral	0.62	deleterious	-6	neutral	0.44	deleterious	-0.34	medium_impact	0.19	medium_impact	0.36	medium_impact	0.57	0.8	8.93	8.99	0.37	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5427	5427	A	C	MI.14782	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	958	320	T	P	Aca/Cca	-6.58	0	0	possibly_damaging	0.64	neutral	0.26	neutral	1.91	neutral	-1.1	deleterious	-3.3	low_impact	1.23	0.9	neutral	0.97	neutral	2.02	16.36	deleterious	0.15	0.45	0.83	disease	0.54	disease	0.27	neutral	0.59	disease	2	0.77	neutral	0.31	neutral	-3	neutral	0.73	deleterious	-1.03	low_impact	-0.04	medium_impact	-0.11	medium_impact	0.31	0.8	8.93	8.99	0.45	N	0.47	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5427	5427	A	G	MI.14783	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	958	320	T	A	Aca/Gca	-6.58	0	0	benign	0.14	neutral	0.58	neutral	1.89	neutral	-1.44	deleterious	-2.88	medium_impact	2.62	0.93	neutral	0.77	neutral	1.63	13.99	neutral	0.39	0.5	0.4	neutral	0.26	neutral	0.46	neutral	0.46	neutral	1	0.32	neutral	0.72	deleterious	-3	neutral	0.28	neutral	-0.08	medium_impact	0.29	medium_impact	1.06	medium_impact	0.27	0.8	8.93	8.99	0.31	N	0.76	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5428	5428	C	A	MI.14784	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	959	320	T	K	aCa/aAa	-2.42	0	0	benign	0.34	neutral	0.4	neutral	2.07	neutral	0.54	deleterious	-2.87	low_impact	0.96	0.87	neutral	0.87	neutral	1.55	13.59	neutral	0.19	0.45	0.77	disease	0.42	neutral	0.38	neutral	0.66	disease	3	0.52	neutral	0.53	deleterious	-6	neutral	0.52	deleterious	-0.53	medium_impact	0.11	medium_impact	-0.34	medium_impact	0.37	0.8	8.93	8.99	0.35	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5428	5428	C	T	MI.14785	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	959	320	T	M	aCa/aTa	-2.42	0	0	benign	0.02	neutral	0.25	neutral	1.84	deleterious	-3.68	deleterious	-2.89	low_impact	1.8	0.98	neutral	0.96	neutral	0.91	10.14	neutral	0.24	0.45	0.35	neutral	0.29	neutral	0.35	neutral	0.45	neutral	1	0.74	neutral	0.62	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	-0.06	medium_impact	0.37	medium_impact	0.56	0.8	8.93	8.99	0.51	N	0.50	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5430	5430	A	G	MI.14786	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	961	321	K	E	Aaa/Gaa	-4.96	0	0	probably_damaging	1	neutral	0.49	neutral	1.82	neutral	-1.86	deleterious	-2.96	medium_impact	3.13	0.91	neutral	0.18	damaging	4.17	23.80	deleterious	0.32	0.5	0.7	disease	0.7	disease	0.67	disease	0.7	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.2	medium_impact	1.49	medium_impact	0.36	0.8	NA	NA	0.34	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5430	5430	A	C	MI.14787	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	961	321	K	Q	Aaa/Caa	-4.96	0	0	probably_damaging	1	neutral	0.47	neutral	1.9	neutral	-0.76	deleterious	-2.93	low_impact	0.92	0.87	neutral	0.53	neutral	2.38	18.69	deleterious	0.52	0.6	0.79	disease	0.35	neutral	0.44	neutral	0.65	disease	3	1	deleterious	0.24	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	0.18	medium_impact	-0.37	medium_impact	0.25	0.8	NA	NA	0.32	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5431	5431	A	T	MI.14788	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	962	321	K	M	aAa/aTa	-0.34	0	0	probably_damaging	1	neutral	0.27	neutral	1.79	neutral	-2.49	deleterious	-4.61	medium_impact	2.33	0.86	neutral	0.22	damaging	3.93	23.50	deleterious	0.19	0.45	0.94	disease	0.52	disease	0.46	neutral	0.8	disease	6	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.03	medium_impact	0.82	medium_impact	0.22	0.8	NA	NA	0.33	N	0.45	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5431	5431	A	C	MI.14789	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	962	321	K	T	aAa/aCa	-0.34	0	0	probably_damaging	1	neutral	0.56	neutral	1.85	neutral	-1.35	deleterious	-4.02	low_impact	1.34	0.88	neutral	0.46	neutral	2.65	20.50	deleterious	0.28	0.45	0.77	disease	0.47	neutral	0.42	neutral	0.63	disease	3	1	deleterious	0.28	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	0.27	medium_impact	-0.02	medium_impact	0.15	0.8	NA	NA	0.29	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8381	8381	A	C	MI.1479	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	16	6	T	P	Act/Cct	-1.49	0	0	probably_damaging	0.99	neutral	1	neutral	2	deleterious	-6.14	deleterious	-5.55	low_impact	1.17	0.99	neutral	0.28	neutral	3.31	22.90	deleterious	0.50472207	0.85	0.73	disease	0.27	neutral	0.61	disease	0.17	neutral	7	0.99	deleterious	0.51	deleterious	-2	neutral	0.78	deleterious	-2.65	low_impact	1.98	high_impact	-0.1	medium_impact	0.57	0.85	7.35	7.2	0.33	N	0.89	polymorphism	0.75	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5432	5432	A	T	MI.14790	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	963	321	K	N	aaA/aaT	1.05	0	0	probably_damaging	1	neutral	0.45	neutral	1.97	neutral	-0.19	deleterious	-3.19	low_impact	1.82	0.87	neutral	0.89	neutral	2.89	21.80	deleterious	0.62	0.65	0.68	disease	0.49	neutral	0.41	neutral	0.49	neutral	0	1	deleterious	0.23	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	0.16	medium_impact	0.39	medium_impact	0.30	0.8	NA	NA	0.36	N	0.69	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5432	5432	A	C	MI.14791	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	963	321	K	N	aaA/aaC	1.05	0	0	probably_damaging	1	neutral	0.45	neutral	1.97	neutral	-0.19	deleterious	-3.19	low_impact	1.82	0.87	neutral	0.89	neutral	2.81	21.40	deleterious	0.62	0.65	0.68	disease	0.49	neutral	0.41	neutral	0.49	neutral	0	1	deleterious	0.23	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	0.16	medium_impact	0.39	medium_impact	0.30	0.8	NA	NA	0.35	N	0.69	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5433	5433	C	A	MI.14792	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	964	322	P	T	Ccc/Acc	-0.11	0	0	benign	0.06	neutral	0.5	neutral	2.01	neutral	0.11	neutral	-0.87	neutral_impact	0.01	0.89	neutral	0.96	neutral	1.85	15.30	deleterious	0.32	0.5	0.5	disease	0.26	neutral	0.29	neutral	0.25	neutral	5	0.45	neutral	0.72	deleterious	-6	neutral	0.28	neutral	0.3	medium_impact	0.21	medium_impact	-1.14	low_impact	0.38	0.8	16.71	9.25	0.39	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5433	5433	C	T	MI.14793	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	964	322	P	S	Ccc/Tcc	-0.11	0	0	benign	0.01	neutral	0.49	neutral	2.03	neutral	0.32	neutral	-0.53	neutral_impact	0.22	0.82	neutral	0.97	neutral	2.13	17.05	deleterious	0.39	0.5	0.42	neutral	0.29	neutral	0.3	neutral	0.46	neutral	1	0.5	neutral	0.74	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.2	medium_impact	-0.96	medium_impact	0.14	0.8	16.71	9.25	0.35	N	0.55	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5433	5433	C	G	MI.14794	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	964	322	P	A	Ccc/Gcc	-0.11	0	0	benign	0.04	neutral	0.5	neutral	1.95	neutral	-0.72	neutral	-0.84	low_impact	1.18	0.88	neutral	0.72	neutral	1.31	12.31	neutral	0.47	0.55	0.34	neutral	0.22	neutral	0.46	neutral	0.41	neutral	2	0.46	neutral	0.73	deleterious	-6	neutral	0.23	neutral	0.47	medium_impact	0.21	medium_impact	-0.15	medium_impact	0.48	0.8	16.71	9.25	0.36	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5434	5434	C	A	MI.14795	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	965	322	P	H	cCc/cAc	-3.81	0	0	possibly_damaging	0.57	neutral	0.53	neutral	1.94	neutral	-0.94	neutral	-0.76	low_impact	1.14	0.82	neutral	0.97	neutral	2.29	18.12	deleterious	0.29	0.45	0.45	neutral	0.46	neutral	0.38	neutral	0.47	neutral	1	0.53	neutral	0.48	deleterious	-3	neutral	0.58	deleterious	-0.91	medium_impact	0.24	medium_impact	-0.19	medium_impact	0.31	0.8	16.71	9.25	0.3	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5434	5434	C	G	MI.14796	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	965	322	P	R	cCc/cGc	-3.81	0	0	benign	0.24	neutral	0.35	neutral	1.93	neutral	-1.33	neutral	-0.04	low_impact	1.48	0.89	neutral	0.67	neutral	1.98	16.11	deleterious	0.18	0.45	0.39	neutral	0.61	disease	0.47	neutral	0.48	neutral	0	0.58	neutral	0.56	deleterious	-6	neutral	0.50	deleterious	-0.34	medium_impact	0.06	medium_impact	0.1	medium_impact	0.34	0.8	16.71	9.25	0.37	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5434	5434	C	T	MI.14797	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	965	322	P	L	cCc/cTc	-3.81	0	0	benign	0	neutral	0.79	neutral	1.96	neutral	-0.63	neutral	-1.29	low_impact	1.28	0.84	neutral	0.88	neutral	2.27	17.94	deleterious	0.19	0.45	0.36	neutral	0.43	neutral	0.45	neutral	0.46	neutral	1	0.2	neutral	0.9	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.53	medium_impact	-0.07	medium_impact	0.61	0.8	16.71	9.25	0.28	N	0.90	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5436	5436	A	T	MI.14798	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	967	323	T	S	Acc/Tcc	-5.66	0	0	benign	0.12	neutral	0.55	neutral	1.96	neutral	-0.25	neutral	-1.1	low_impact	0.82	0.87	neutral	0.86	neutral	2.43	19.00	deleterious	0.45	0.55	0.38	neutral	0.23	neutral	0.28	neutral	0.44	neutral	1	0.36	neutral	0.72	deleterious	-6	neutral	0.42	neutral	-0.01	medium_impact	0.26	medium_impact	-0.45	medium_impact	0.49	0.8	16.43	9.29	0.35	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5436	5436	A	C	MI.14799	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	967	323	T	P	Acc/Ccc	-5.66	0	0	benign	0.36	neutral	0.23	neutral	1.84	neutral	-1.66	neutral	-2.5	low_impact	1.55	0.88	neutral	0.79	neutral	2.86	21.70	deleterious	0.12	0.4	0.66	disease	0.71	disease	0.28	neutral	0.54	disease	1	0.73	neutral	0.44	neutral	-6	neutral	0.66	deleterious	-0.57	medium_impact	-0.08	medium_impact	0.16	medium_impact	0.35	0.8	16.43	9.29	0.39	N	0.73	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8596	8596	A	G	MI.148	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	70	24	I	V	Att/Gtt	-7.51	0	0	probably_damaging	0.93	neutral	0.34	neutral	4.15	neutral	-1.03	neutral	-0.7	low_impact	1.25	0.94	neutral	0.97	neutral	1.59	13.81	neutral	0.65	0.7	0.34	neutral	0.2	neutral	0.35	neutral	0.38	neutral	2	0.94	neutral	0.21	neutral	-2	neutral	0.60	deleterious	-1.82	low_impact	0.13	medium_impact	-0.03	medium_impact	0.51	0.9	18.14	17.22	0.42	N	0.04	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8382	8382	C	A	MI.1480	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	17	6	T	N	aCt/aAt	3.83	0.99	0	probably_damaging	0.99	neutral	0.05	neutral	1.48	deleterious	-5.68	deleterious	-4.66	medium_impact	3.34	0.99	neutral	0.43	neutral	3.50	23.10	deleterious	0.61963595	0.85	0.69	disease	0.23	neutral	0.68	disease	0.21	neutral	6	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	-0.43	medium_impact	1.77	medium_impact	0.73	0.85	7.35	7.2	0.69	P	0.85	disease_causing	0.96	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5436	5436	A	G	MI.14800	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	967	323	T	A	Acc/Gcc	-5.66	0	0	benign	0.07	neutral	0.51	neutral	1.83	neutral	-1.92	neutral	-1.3	medium_impact	2.34	0.92	neutral	0.89	neutral	2.56	19.88	deleterious	0.27	0.45	0.35	neutral	0.29	neutral	0.43	neutral	0.45	neutral	1	0.43	neutral	0.72	deleterious	-3	neutral	0.35	neutral	0.23	medium_impact	0.22	medium_impact	0.83	medium_impact	0.24	0.8	16.43	9.29	0.35	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5437	5437	C	T	MI.14801	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	968	323	T	I	aCc/aTc	-1.72	0	0	benign	0.08	neutral	0.48	neutral	1.85	neutral	-1.56	neutral	-0.68	low_impact	1.07	0.9	neutral	0.94	neutral	2.50	19.44	deleterious	0.19	0.45	0.42	neutral	0.45	neutral	0.33	neutral	0.46	neutral	1	0.46	neutral	0.7	deleterious	-6	neutral	0.40	neutral	0.17	medium_impact	0.19	medium_impact	-0.24	medium_impact	0.34	0.8	16.43	9.29	0.37	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5437	5437	C	A	MI.14802	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	968	323	T	N	aCc/aAc	-1.72	0	0	benign	0.36	neutral	0.39	neutral	1.95	neutral	-0.34	neutral	-2.27	low_impact	1.58	0.79	neutral	0.95	neutral	2.09	16.78	deleterious	0.4	0.5	0.33	neutral	0.42	neutral	0.3	neutral	0.47	neutral	1	0.54	neutral	0.52	deleterious	-6	neutral	0.52	deleterious	-0.57	medium_impact	0.1	medium_impact	0.19	medium_impact	0.36	0.8	16.43	9.29	0.37	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5437	5437	C	G	MI.14803	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	968	323	T	S	aCc/aGc	-1.72	0	0	benign	0.12	neutral	0.55	neutral	1.96	neutral	-0.25	neutral	-1.1	low_impact	0.82	0.87	neutral	0.86	neutral	2.10	16.83	deleterious	0.45	0.55	0.38	neutral	0.23	neutral	0.28	neutral	0.44	neutral	1	0.36	neutral	0.72	deleterious	-6	neutral	0.42	neutral	-0.01	medium_impact	0.26	medium_impact	-0.45	medium_impact	0.49	0.8	16.43	9.29	0.34	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5439	5439	C	G	MI.14804	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	970	324	P	A	Cca/Gca	-4.27	0	0	benign	0	neutral	0.52	neutral	2.04	neutral	0.81	deleterious	-3.12	neutral_impact	0.62	0.86	neutral	0.89	neutral	1.19	11.70	neutral	0.23	0.45	0.86	disease	0.09	neutral	0.43	neutral	0.36	neutral	3	0.47	neutral	0.76	deleterious	-6	neutral	0.70	deleterious	1.95	medium_impact	0.23	medium_impact	-0.62	medium_impact	0.56	0.8	8.93	8.2	0.36	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5439	5439	C	A	MI.14805	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	970	324	P	T	Cca/Aca	-4.27	0	0	benign	0.01	neutral	0.46	neutral	2.08	neutral	1.33	neutral	-2.34	neutral_impact	-0.8	0.83	neutral	0.98	neutral	1.85	15.29	deleterious	0.26	0.45	0.84	disease	0.08	neutral	0.18	neutral	0.36	neutral	3	0.53	neutral	0.73	deleterious	-6	neutral	0.69	deleterious	1.03	medium_impact	0.17	medium_impact	-1.82	low_impact	0.46	0.8	8.93	8.2	0.45	N	0.19	polymorphism	1	0.02	rs879127743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5439	5439	C	T	MI.14806	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	970	324	P	S	Cca/Tca	-4.27	0	0	benign	0.02	neutral	0.47	neutral	2.03	neutral	0.7	deleterious	-2.84	neutral_impact	0.45	0.73	neutral	0.91	neutral	2.25	17.84	deleterious	0.26	0.45	0.88	disease	0.14	neutral	0.23	neutral	0.38	neutral	2	0.51	neutral	0.73	deleterious	-6	neutral	0.71	deleterious	0.75	medium_impact	0.18	medium_impact	-0.77	medium_impact	0.23	0.8	8.93	8.2	0.35	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5440	5440	C	G	MI.14807	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	971	324	P	R	cCa/cGa	-1.03	0	0	benign	0.04	neutral	0.35	neutral	1.96	neutral	-1.71	deleterious	-3.61	low_impact	1.06	0.89	neutral	0.55	neutral	2.06	16.58	deleterious	0.18	0.45	0.9	disease	0.41	neutral	0.62	disease	0.67	disease	3	0.62	neutral	0.66	deleterious	-6	neutral	0.79	deleterious	0.47	medium_impact	0.06	medium_impact	-0.25	medium_impact	0.53	0.8	8.93	8.2	0.4	N	0.72	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5440	5440	C	A	MI.14808	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	971	324	P	Q	cCa/cAa	-1.03	0	0	benign	0.08	neutral	0.29	neutral	1.98	neutral	-0.75	deleterious	-3.15	low_impact	1.06	0.85	neutral	0.58	neutral	2.70	20.80	deleterious	0.21	0.45	0.9	disease	0.26	neutral	0.36	neutral	0.58	disease	2	0.68	neutral	0.61	deleterious	-6	neutral	0.75	deleterious	0.17	medium_impact	-0.01	medium_impact	-0.25	medium_impact	0.36	0.8	8.93	8.2	0.38	N	0.72	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5440	5440	C	T	MI.14809	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	971	324	P	L	cCa/cTa	-1.03	0	0	benign	0	neutral	0.74	neutral	2.28	neutral	2.69	deleterious	-3.8	neutral_impact	-0.46	0.93	neutral	0.96	neutral	2.21	17.59	deleterious	0.25	0.45	0.83	disease	0.19	neutral	0.44	neutral	0.44	neutral	1	0.26	neutral	0.87	deleterious	-6	neutral	0.73	deleterious	1.95	medium_impact	0.46	medium_impact	-1.53	low_impact	0.51	0.8	8.93	8.2	0.37	N	0.24	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8382	8382	C	T	MI.1481	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	17	6	T	I	aCt/aTt	3.83	0.99	0	probably_damaging	0.99	neutral	0.2	neutral	1.52	deleterious	-5.39	deleterious	-4.99	medium_impact	1.95	0.98	neutral	0.53	neutral	3.89	23.50	deleterious	0.57868449	0.85	0.68	disease	0.22	neutral	0.55	disease	0.17	neutral	7	0.99	deleterious	0.11	neutral	1	deleterious	0.77	deleterious	-2.65	low_impact	-0.05	medium_impact	0.57	medium_impact	0.63	0.85	7.35	7.2	0.68	P	0.76	disease_causing	0.96	0.24	.	Uncertain_significance	not_provided	438890	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5442	5442	T	A	MI.14810	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	973	325	F	I	Ttc/Atc	-11.21	0	0.01	benign	0.01	neutral	0.64	neutral	2.1	neutral	1.22	neutral	0.28	neutral_impact	-0.66	0.91	neutral	0.95	neutral	2.89	21.80	deleterious	0.17	0.45	0.4	neutral	0.1	neutral	0.47	neutral	0.31	neutral	4	0.35	neutral	0.82	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.35	medium_impact	-1.7	low_impact	0.35	0.8	NA	NA	0.29	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5442	5442	T	G	MI.14811	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	973	325	F	V	Ttc/Gtc	-11.21	0	0.01	benign	0.01	neutral	0.55	neutral	2.01	neutral	0.15	neutral	-0.41	neutral_impact	0.11	0.89	neutral	0.77	neutral	2.91	21.90	deleterious	0.17	0.45	0.37	neutral	0.26	neutral	0.59	disease	0.46	neutral	1	0.44	neutral	0.77	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.26	medium_impact	-1.05	low_impact	0.28	0.8	NA	NA	0.33	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5442	5442	T	C	MI.14812	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	973	325	F	L	Ttc/Ctc	-11.21	0	0.01	benign	0	neutral	0.96	neutral	2.25	neutral	2.21	neutral	1.48	neutral_impact	-1.74	0.99	neutral	0.99	neutral	-0.10	1.70	neutral	0.17	0.45	0.35	neutral	0.07	neutral	0.38	neutral	0.19	neutral	6	0.04	neutral	0.98	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.98	medium_impact	-2.61	low_impact	0.24	0.8	NA	NA	0.29	N	0.01	polymorphism	1	0.01	rs3020601	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5443	5443	T	A	MI.14813	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	974	325	F	Y	tTc/tAc	-5.66	0	0	benign	0.02	neutral	1	neutral	1.99	neutral	-0.24	neutral	-0.92	neutral_impact	0	0.88	neutral	0.83	neutral	1.67	14.22	neutral	0.18	0.45	0.76	disease	0.18	neutral	0.48	neutral	0.44	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.25	neutral	0.75	medium_impact	1.87	high_impact	-1.14	low_impact	0.33	0.8	NA	NA	0.3	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5443	5443	T	C	MI.14814	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	974	325	F	S	tTc/tCc	-5.66	0	0	benign	0.02	neutral	0.59	neutral	1.99	neutral	-0.16	neutral	-2.3	neutral_impact	0.11	0.79	neutral	0.95	neutral	3.04	22.30	deleterious	0.11	0.4	0.7	disease	0.23	neutral	0.54	disease	0.55	disease	1	0.37	neutral	0.79	deleterious	-6	neutral	0.31	neutral	0.75	medium_impact	0.3	medium_impact	-1.05	low_impact	0.19	0.8	NA	NA	0.28	N	0.72	polymorphism	1	0.06	rs878943513	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5443	5443	T	G	MI.14815	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	974	325	F	C	tTc/tGc	-5.66	0	0	benign	0.19	neutral	0.17	neutral	1.94	neutral	-1.9	neutral	-1	neutral_impact	-0.55	0.9	neutral	0.76	neutral	3.04	22.30	deleterious	0.13	0.4	0.89	disease	0.42	neutral	0.64	disease	0.66	disease	3	0.8	neutral	0.49	deleterious	-6	neutral	0.53	deleterious	-0.22	medium_impact	-0.17	medium_impact	-1.61	low_impact	0.18	0.8	NA	NA	0.43	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5444	5444	C	A	MI.14816	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	975	325	F	L	ttC/ttA	-0.34	0	0	benign	0	neutral	0.96	neutral	2.25	neutral	2.21	neutral	1.48	neutral_impact	-1.74	0.99	neutral	0.99	neutral	0.53	7.65	deleterious	0.17	0.45	0.35	neutral	0.07	neutral	0.38	neutral	0.19	neutral	6	0.04	neutral	0.98	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.98	medium_impact	-2.61	low_impact	0.24	0.8	NA	NA	0.4	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5444	5444	C	G	MI.14817	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	975	325	F	L	ttC/ttG	-0.34	0	0	benign	0	neutral	0.96	neutral	2.25	neutral	2.21	neutral	1.48	neutral_impact	-1.74	0.99	neutral	0.99	neutral	0.21	4.79	deleterious	0.17	0.45	0.35	neutral	0.07	neutral	0.38	neutral	0.19	neutral	6	0.04	neutral	0.98	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.98	medium_impact	-2.61	low_impact	0.24	0.8	NA	NA	0.4	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5445	5445	C	T	MI.14818	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	976	326	L	F	Ctc/Ttc	-9.36	0	0	benign	0.16	neutral	0.71	neutral	1.45	deleterious	-3.47	deleterious	-3.07	medium_impact	3.01	0.94	neutral	0.63	neutral	4.00	23.60	deleterious	0.24	0.45	0.65	disease	0.4	neutral	0.42	neutral	0.62	disease	2	0.17	neutral	0.78	deleterious	-3	neutral	0.54	deleterious	-0.14	medium_impact	0.42	medium_impact	1.39	medium_impact	0.48	0.8	NA	NA	0.27	N	0.24	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5445	5445	C	G	MI.14819	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	976	326	L	V	Ctc/Gtc	-9.36	0	0	benign	0.03	neutral	0.46	neutral	1.51	neutral	-2.57	neutral	-1.91	medium_impact	2.16	0.91	neutral	0.76	neutral	3.32	22.90	deleterious	0.22	0.45	0.55	disease	0.26	neutral	0.39	neutral	0.55	disease	1	0.51	neutral	0.72	deleterious	-3	neutral	0.28	neutral	0.59	medium_impact	0.17	medium_impact	0.67	medium_impact	0.29	0.8	NA	NA	0.4	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8382	8382	C	G	MI.1482	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	17	6	T	S	aCt/aGt	3.83	0.99	0	probably_damaging	0.97	neutral	0.08	neutral	1.5	deleterious	-4.36	deleterious	-3.66	medium_impact	2.99	0.99	neutral	0.46	neutral	3.43	23.00	deleterious	0.57868449	0.85	0.46	neutral	0.13	neutral	0.63	disease	0.21	neutral	6	0.99	deleterious	0.06	neutral	1	deleterious	0.71	deleterious	-2.19	low_impact	-0.31	medium_impact	1.47	medium_impact	0.62	0.85	7.35	7.2	0.71	P	0.77	disease_causing	0.69	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5445	5445	C	A	MI.14820	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	976	326	L	I	Ctc/Atc	-9.36	0	0	benign	0	neutral	0.49	neutral	1.6	neutral	-1.74	neutral	-1.24	low_impact	1.64	0.94	neutral	0.94	neutral	2.47	19.29	deleterious	0.23	0.45	0.53	disease	0.07	neutral	0.33	neutral	0.26	neutral	5	0.51	neutral	0.75	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.2	medium_impact	0.24	medium_impact	0.38	0.8	NA	NA	0.42	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5446	5446	T	G	MI.14821	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	977	326	L	R	cTc/cGc	-2.65	0	0	possibly_damaging	0.54	neutral	0.3	neutral	1.4	deleterious	-5.6	deleterious	-4.75	medium_impact	3.36	0.84	neutral	0.43	neutral	4.26	23.90	deleterious	0.1	0.4	0.88	disease	0.76	disease	0.7	disease	0.78	disease	6	0.69	neutral	0.38	neutral	0	NA	0.77	deleterious	-0.86	medium_impact	0	medium_impact	1.68	medium_impact	0.25	0.8	NA	NA	0.35	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5446	5446	T	A	MI.14822	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	977	326	L	H	cTc/cAc	-2.65	0	0	possibly_damaging	0.63	neutral	0.48	neutral	1.4	deleterious	-5.14	deleterious	-5.61	medium_impact	3.36	0.84	neutral	0.53	neutral	4.24	23.90	deleterious	0.12	0.4	0.91	disease	0.63	disease	0.66	disease	0.75	disease	5	0.61	neutral	0.43	neutral	0	NA	0.75	deleterious	-1.01	low_impact	0.19	medium_impact	1.68	medium_impact	0.28	0.8	NA	NA	0.33	N	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5446	5446	T	C	MI.14823	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	977	326	L	P	cTc/cCc	-2.65	0	0	possibly_damaging	0.54	neutral	0.22	neutral	1.4	deleterious	-5.5	deleterious	-5.57	medium_impact	2.12	0.86	neutral	0.35	neutral	3.98	23.60	deleterious	0.09	0.35	0.8	disease	0.74	disease	0.59	disease	0.73	disease	5	0.77	neutral	0.34	neutral	0	NA	0.76	deleterious	-0.86	medium_impact	-0.1	medium_impact	0.64	medium_impact	0.24	0.8	NA	NA	0.32	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5448	5448	C	T	MI.14824	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	979	327	P	S	Ccc/Tcc	-6.35	0	0	benign	0.01	neutral	0.73	neutral	2.23	neutral	1.69	deleterious	-3.19	neutral_impact	0.56	0.91	neutral	0.98	neutral	2.28	18.01	deleterious	0.32	0.5	0.51	disease	0.15	neutral	0.37	neutral	0.27	neutral	5	0.24	neutral	0.86	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.45	medium_impact	-0.67	medium_impact	0.25	0.8	NA	NA	0.39	N	0.44	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5448	5448	C	G	MI.14825	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	979	327	P	A	Ccc/Gcc	-6.35	0	0	benign	0.08	neutral	0.53	neutral	2.21	neutral	1.61	deleterious	-3.52	neutral_impact	0.6	0.8	neutral	0.98	neutral	1.77	14.81	neutral	0.25	0.45	0.49	neutral	0.05	neutral	0.49	neutral	0.21	neutral	6	0.4	neutral	0.73	deleterious	-6	neutral	0.29	neutral	0.17	medium_impact	0.24	medium_impact	-0.64	medium_impact	0.61	0.8	NA	NA	0.39	N	0.48	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5448	5448	C	A	MI.14826	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	979	327	P	T	Ccc/Acc	-6.35	0	0	benign	0.12	neutral	0.6	neutral	2.04	neutral	0.45	deleterious	-3.93	neutral_impact	0.76	0.84	neutral	0.89	neutral	2.56	19.86	deleterious	0.28	0.45	0.4	neutral	0.16	neutral	0.35	neutral	0.31	neutral	4	0.3	neutral	0.74	deleterious	-6	neutral	0.36	neutral	-0.01	medium_impact	0.31	medium_impact	-0.51	medium_impact	0.61	0.8	NA	NA	0.34	N	0.66	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5449	5449	C	A	MI.14827	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	980	327	P	H	cCc/cAc	-0.57	0	0	possibly_damaging	0.75	neutral	0.41	neutral	1.9	neutral	-2.66	deleterious	-5.33	medium_impact	2.96	0.89	neutral	0.39	neutral	4.13	23.80	deleterious	0.2	0.45	0.6	disease	0.43	neutral	0.64	disease	0.65	disease	3	0.75	neutral	0.33	neutral	0	NA	0.65	deleterious	-1.23	low_impact	0.12	medium_impact	1.35	medium_impact	0.41	0.8	NA	NA	0.42	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5449	5449	C	T	MI.14828	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	980	327	P	L	cCc/cTc	-0.57	0	0	benign	0.31	neutral	1	neutral	1.93	neutral	-1.33	deleterious	-5.92	medium_impact	2.15	0.9	neutral	0.55	neutral	4.44	24.20	deleterious	0.21	0.45	0.51	disease	0.4	neutral	0.33	neutral	0.37	neutral	3	0.31	neutral	0.85	deleterious	-3	neutral	0.47	deleterious	-0.48	medium_impact	1.87	high_impact	0.67	medium_impact	0.52	0.8	NA	NA	0.28	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5449	5449	C	G	MI.14829	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	980	327	P	R	cCc/cGc	-0.57	0	0	possibly_damaging	0.5	neutral	0.31	neutral	1.92	neutral	-1.6	deleterious	-5.18	medium_impact	2.96	0.89	neutral	0.38	neutral	3.66	23.20	deleterious	0.19	0.45	0.56	disease	0.55	disease	0.68	disease	0.72	disease	4	0.66	neutral	0.41	neutral	0	NA	0.58	deleterious	-0.8	medium_impact	0.02	medium_impact	1.35	medium_impact	0.50	0.8	NA	NA	0.41	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8384	8384	A	G	MI.1483	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	19	7	T	A	Acc/Gcc	-2.42	0	0	benign	0	neutral	0.88	neutral	2.2	neutral	-0.48	neutral	-0.48	low_impact	1.28	1	neutral	0.81	neutral	0.89	9.99	deleterious	0.55484047	0.85	0.22	neutral	0.09	neutral	0.48	neutral	0.12	neutral	8	0.12	neutral	0.94	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.78	medium_impact	0	medium_impact	0.45	0.85	5.88	6.93	0.34	N	0.15	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5451	5451	A	C	MI.14830	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	982	328	T	P	Aca/Cca	-5.89	0	0	benign	0	neutral	0.26	neutral	1.83	neutral	-2.15	neutral	2.73	neutral_impact	-0.58	0.97	neutral	0.97	neutral	0.81	9.53	deleterious	0.11	0.4	0.85	disease	0.27	neutral	0.4	neutral	0.6	disease	2	0.74	neutral	0.63	deleterious	-6	neutral	0.22	neutral	1.95	medium_impact	-0.04	medium_impact	-1.63	low_impact	0.32	0.8	1.15	7.37	0.36	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5451	5451	A	G	MI.14831	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	982	328	T	A	Aca/Gca	-5.89	0	0	benign	0.01	neutral	0.61	neutral	1.87	neutral	-1.32	neutral	-0.94	low_impact	0.88	0.94	neutral	0.87	neutral	2.09	16.81	deleterious	0.28	0.45	0.48	neutral	0.12	neutral	0.33	neutral	0.26	neutral	5	0.38	neutral	0.8	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	0.32	medium_impact	-0.4	medium_impact	0.15	0.8	1.15	7.37	0.34	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5451	5451	A	T	MI.14832	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	982	328	T	S	Aca/Tca	-5.89	0	0	benign	0.02	neutral	0.65	neutral	1.84	neutral	-1.95	neutral	-0.92	low_impact	1.05	0.9	neutral	0.93	neutral	2.00	16.23	deleterious	0.39	0.5	0.54	disease	0.19	neutral	0.33	neutral	0.33	neutral	3	0.32	neutral	0.82	deleterious	-6	neutral	0.19	neutral	0.75	medium_impact	0.36	medium_impact	-0.26	medium_impact	0.50	0.8	1.15	7.37	0.34	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5452	5452	C	A	MI.14833	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	983	328	T	K	aCa/aAa	-2.42	0	0	benign	0.02	neutral	0.31	neutral	1.8	deleterious	-3.97	neutral	-1.64	medium_impact	2.2	0.85	neutral	0.43	neutral	4.33	24.00	deleterious	0.13	0.4	0.87	disease	0.52	disease	0.73	disease	0.75	disease	5	0.68	neutral	0.65	deleterious	-3	neutral	0.31	neutral	0.75	medium_impact	0.02	medium_impact	0.71	medium_impact	0.36	0.8	1.15	7.37	0.34	N	0.84	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5452	5452	C	T	MI.14834	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	983	328	T	M	aCa/aTa	-2.42	0	0	benign	0.06	neutral	0.33	neutral	1.91	neutral	-0.84	neutral	-2.06	low_impact	1.3	0.91	neutral	0.78	neutral	2.97	22.10	deleterious	0.15	0.45	0.8	disease	0.24	neutral	0.43	neutral	0.57	disease	1	0.64	neutral	0.64	deleterious	-6	neutral	0.36	neutral	0.3	medium_impact	0.04	medium_impact	-0.05	medium_impact	0.46	0.8	1.15	7.37	0.49	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	CPD	0.15	C5452T	Progressive Encephalomyopathy	+	-	Reported	1	.	P	P	neutral
chrM	5454	5454	C	T	MI.14835	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	985	329	L	F	Ctc/Ttc	-7.74	0	0	probably_damaging	0.98	neutral	0.76	neutral	1.58	neutral	-2.67	deleterious	-2.87	medium_impact	1.99	0.93	neutral	0.8	neutral	3.93	23.50	deleterious	0.24	0.45	0.65	disease	0.27	neutral	0.47	neutral	0.56	disease	1	0.98	neutral	0.39	neutral	1	deleterious	0.71	deleterious	-2.34	low_impact	0.49	medium_impact	0.53	medium_impact	0.61	0.8	NA	NA	0.31	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5454	5454	C	G	MI.14836	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	985	329	L	V	Ctc/Gtc	-7.74	0	0	possibly_damaging	0.89	neutral	0.54	neutral	1.6	neutral	-2.34	neutral	-2.22	medium_impact	2.42	0.91	neutral	0.68	neutral	3.35	22.90	deleterious	0.23	0.45	0.51	disease	0.21	neutral	0.43	neutral	0.3	neutral	4	0.88	neutral	0.33	neutral	0	NA	0.66	deleterious	-1.63	low_impact	0.25	medium_impact	0.89	medium_impact	0.40	0.8	NA	NA	0.33	N	0.41	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5454	5454	C	A	MI.14837	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	985	329	L	I	Ctc/Atc	-7.74	0	0	probably_damaging	0.93	neutral	0.48	neutral	1.57	neutral	-2.71	neutral	-1.47	low_impact	1.57	0.93	neutral	0.86	neutral	2.92	21.90	deleterious	0.22	0.45	0.57	disease	0.12	neutral	0.35	neutral	0.3	neutral	4	0.92	neutral	0.28	neutral	-2	neutral	0.65	deleterious	-1.83	low_impact	0.19	medium_impact	0.18	medium_impact	0.55	0.8	NA	NA	0.36	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5455	5455	T	G	MI.14838	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	986	329	L	R	cTc/cGc	-3.81	0	0	probably_damaging	0.98	neutral	0.41	neutral	1.5	deleterious	-5.4	deleterious	-4.92	medium_impact	3.31	0.81	neutral	0.43	neutral	4.23	23.90	deleterious	0.09	0.35	0.88	disease	0.69	disease	0.76	disease	0.79	disease	6	0.98	neutral	0.22	neutral	1	deleterious	0.82	deleterious	-2.34	low_impact	0.12	medium_impact	1.64	medium_impact	0.31	0.8	NA	NA	0.35	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5455	5455	T	A	MI.14839	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	986	329	L	H	cTc/cAc	-3.81	0	0	probably_damaging	0.99	neutral	0.55	neutral	1.49	deleterious	-5.93	deleterious	-5.7	medium_impact	3.31	0.82	neutral	0.48	neutral	4.34	24.00	deleterious	0.13	0.4	0.91	disease	0.55	disease	0.73	disease	0.78	disease	6	0.98	deleterious	0.28	neutral	1	deleterious	0.78	deleterious	-2.62	low_impact	0.26	medium_impact	1.64	medium_impact	0.23	0.8	NA	NA	0.28	N	0.85	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8384	8384	A	C	MI.1484	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	19	7	T	P	Acc/Ccc	-2.42	0	0	benign	0.05	neutral	0.25	neutral	1.91	neutral	-2.72	deleterious	-2.5	medium_impact	2.33	0.99	neutral	0.42	neutral	1.99	16.15	deleterious	0.24683078	0.85	0.56	disease	0.31	neutral	0.54	disease	0.2	neutral	6	0.73	neutral	0.6	deleterious	-3	neutral	0.22	neutral	0.46	medium_impact	0.02	medium_impact	0.9	medium_impact	0.58	0.85	5.88	6.93	0.5	N	0.24	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5455	5455	T	C	MI.14840	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	986	329	L	P	cTc/cCc	-3.81	0	0	probably_damaging	0.99	neutral	0.26	neutral	1.56	neutral	-2.98	deleterious	-5.82	medium_impact	2.62	0.87	neutral	0.5	neutral	3.99	23.60	deleterious	0.11	0.4	0.91	disease	0.65	disease	0.63	disease	0.75	disease	5	0.99	deleterious	0.14	neutral	1	deleterious	0.82	deleterious	-2.62	low_impact	-0.04	medium_impact	1.06	medium_impact	0.29	0.8	NA	NA	0.36	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5457	5457	A	C	MI.14841	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	988	330	I	L	Atc/Ctc	-2.65	0	0	benign	0	neutral	1	neutral	1.98	neutral	-0.12	neutral	-1.26	low_impact	1.12	0.84	neutral	0.89	neutral	0.93	10.23	neutral	0.18	0.45	0.53	disease	0.35	neutral	0.26	neutral	0.45	neutral	1	0	neutral	1	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	1.87	high_impact	-0.2	medium_impact	0.33	0.8	NA	NA	0.26	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5457	5457	A	G	MI.14842	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	988	330	I	V	Atc/Gtc	-2.65	0	0	benign	0.01	neutral	0.42	neutral	1.92	neutral	-0.73	neutral	-0.7	low_impact	1.3	0.92	neutral	0.98	neutral	0.23	4.95	deleterious	0.21	0.45	0.48	neutral	0.17	neutral	0.37	neutral	0.31	neutral	4	0.57	neutral	0.71	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.13	medium_impact	-0.05	medium_impact	0.16	0.8	NA	NA	0.43	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5457	5457	A	T	MI.14843	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	988	330	I	F	Atc/Ttc	-2.65	0	0	benign	0.08	neutral	0.7	neutral	1.84	neutral	-1.84	deleterious	-2.51	medium_impact	2.15	0.95	neutral	0.78	neutral	3.51	23.10	deleterious	0.12	0.4	0.51	disease	0.51	disease	0.39	neutral	0.49	neutral	0	0.21	neutral	0.81	deleterious	-3	neutral	0.31	neutral	0.17	medium_impact	0.41	medium_impact	0.67	medium_impact	0.32	0.8	NA	NA	0.24	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5458	5458	T	A	MI.14844	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	989	330	I	N	aTc/aAc	-1.26	0	0	benign	0.32	neutral	0.23	neutral	1.82	neutral	-2.39	deleterious	-5.47	medium_impact	1.98	0.89	neutral	0.42	neutral	4.35	24.10	deleterious	0.13	0.4	0.83	disease	0.69	disease	0.6	disease	0.74	disease	5	0.72	neutral	0.46	neutral	-3	neutral	0.54	deleterious	-0.5	medium_impact	-0.08	medium_impact	0.52	medium_impact	0.22	0.8	NA	NA	0.41	N	0.57	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5458	5458	T	C	MI.14845	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	989	330	I	T	aTc/aCc	-1.26	0	0	benign	0.08	neutral	0.6	neutral	1.99	neutral	-0.1	deleterious	-3.56	neutral_impact	0.38	0.92	neutral	0.95	neutral	0.30	5.68	deleterious	0.18	0.45	0.52	disease	0.13	neutral	0.31	neutral	0.2	neutral	6	0.32	neutral	0.76	deleterious	-6	neutral	0.28	neutral	0.17	medium_impact	0.31	medium_impact	-0.83	medium_impact	0.27	0.8	NA	NA	0.38	N	0.05	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5458	5458	T	G	MI.14846	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	989	330	I	S	aTc/aGc	-1.26	0	0	benign	0.1	neutral	0.47	neutral	2	neutral	-0.02	deleterious	-4.43	low_impact	1.25	0.87	neutral	0.69	neutral	4.06	23.70	deleterious	0.1	0.4	0.6	disease	0.56	disease	0.42	neutral	0.51	disease	0	0.46	neutral	0.69	deleterious	-6	neutral	0.33	neutral	0.08	medium_impact	0.18	medium_impact	-0.09	medium_impact	0.23	0.8	NA	NA	0.31	N	0.40	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5459	5459	C	A	MI.14847	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	990	330	I	M	atC/atA	-0.57	0	0	benign	0	neutral	0.38	neutral	1.9	neutral	-0.93	neutral	-1.93	low_impact	1.91	0.93	neutral	0.78	neutral	2.47	19.29	deleterious	0.21	0.45	0.35	neutral	0.29	neutral	0.32	neutral	0.46	neutral	1	0.62	neutral	0.69	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.09	medium_impact	0.46	medium_impact	0.35	0.8	NA	NA	0.41	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5459	5459	C	G	MI.14848	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	990	330	I	M	atC/atG	-0.57	0	0	benign	0	neutral	0.38	neutral	1.9	neutral	-0.93	neutral	-1.93	low_impact	1.91	0.93	neutral	0.78	neutral	1.98	16.09	deleterious	0.21	0.45	0.35	neutral	0.29	neutral	0.32	neutral	0.46	neutral	1	0.62	neutral	0.69	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.09	medium_impact	0.46	medium_impact	0.35	0.8	NA	NA	0.41	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5460	5460	G	C	MI.14849	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	991	331	A	P	Gcc/Ccc	-8.9	0	0.21	benign	0	neutral	0.23	neutral	1.99	neutral	-0.08	neutral	-1.78	neutral_impact	0.34	0.82	neutral	0.57	neutral	1.96	15.94	deleterious	0.11	0.4	0.87	disease	0.58	disease	0.56	disease	0.67	disease	3	0.77	neutral	0.62	deleterious	-6	neutral	0.28	neutral	1.95	medium_impact	-0.08	medium_impact	-0.86	medium_impact	0.40	0.8	NA	NA	0.3	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8384	8384	A	T	MI.1485	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	19	7	T	S	Acc/Tcc	-2.42	0	0	benign	0.01	neutral	0.84	neutral	2.18	neutral	2.3	neutral	1.84	neutral_impact	-1.11	0.93	neutral	0.94	neutral	-0.88	0.03	neutral	0.37202141	0.85	0.1	neutral	0.01	neutral	0.34	neutral	0.08	neutral	8	0.13	neutral	0.92	deleterious	-6	neutral	0.09	neutral	1.14	medium_impact	0.7	medium_impact	-2.05	low_impact	0.64	0.85	5.88	6.93	0.33	N	0.05	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5460	5460	G	A	MI.14850	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	991	331	A	T	Gcc/Acc	-8.9	0	0.21	benign	0	neutral	0.63	neutral	2.12	neutral	1.12	neutral	0.8	neutral_impact	-1.01	0.95	neutral	0.98	neutral	0.76	9.23	deleterious	0.18	0.45	0.37	neutral	0.06	neutral	0.31	neutral	0.21	neutral	6	0.37	neutral	0.82	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.34	medium_impact	-2	low_impact	0.65	0.8	NA	NA	0.33	N	0.02	polymorphism	1	0.01	rs3021088	.	.	.	.	.	.	.	.	G5460A	AD / PD	+	+	Conflicting reports	8	N	N	N	neutral
chrM	5460	5460	G	T	MI.14851	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	991	331	A	S	Gcc/Tcc	-8.9	0	0.21	benign	0	neutral	0.55	neutral	2	neutral	0.02	neutral	-0.79	neutral_impact	0	0.37	damaging	0.96	neutral	0.65	8.48	deleterious	0.23	0.45	0.42	neutral	0.13	neutral	0.35	neutral	0.32	neutral	4	0.45	neutral	0.78	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.26	medium_impact	-1.14	low_impact	0.28	0.8	NA	NA	0.8	P	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	G5460T	AD	+	+	Reported	5	.	P	P	neutral
chrM	5461	5461	C	A	MI.14852	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	992	331	A	D	gCc/gAc	-1.26	0	0	benign	0	neutral	0.18	neutral	1.89	deleterious	-4.17	neutral	-2.03	low_impact	1.32	0.88	neutral	0.5	neutral	2.69	20.70	deleterious	0.09	0.35	0.91	disease	0.55	disease	0.72	disease	0.8	disease	6	0.82	neutral	0.59	deleterious	-6	neutral	0.25	neutral	1.95	medium_impact	-0.16	medium_impact	-0.03	medium_impact	0.24	0.8	NA	NA	0.36	N	0.38	polymorphism	1	0.03	rs878985080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5461	5461	C	T	MI.14853	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	992	331	A	V	gCc/gTc	-1.26	0	0	benign	0	neutral	0.66	neutral	2.06	neutral	0.63	neutral	2.7	neutral_impact	-1.07	0.93	neutral	0.97	neutral	0.82	9.60	deleterious	0.16	0.45	0.33	neutral	0.14	neutral	0.36	neutral	0.28	neutral	4	0.34	neutral	0.83	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.37	medium_impact	-2.05	low_impact	0.69	0.85	NA	NA	0.27	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5461	5461	C	G	MI.14854	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	992	331	A	G	gCc/gGc	-1.26	0	0	benign	0	neutral	0.37	neutral	1.9	deleterious	-3.03	deleterious	-2.64	low_impact	1.32	0.91	neutral	0.58	neutral	2.16	17.26	deleterious	0.2	0.45	0.66	disease	0.25	neutral	0.59	disease	0.58	disease	2	0.63	neutral	0.69	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	0.08	medium_impact	-0.03	medium_impact	0.50	0.8	NA	NA	0.38	N	0.35	polymorphism	1	0.06	rs878985080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5463	5463	C	A	MI.14855	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	994	332	L	I	Ctt/Att	-14.45	0	0	benign	0.01	neutral	0.4	neutral	1.87	neutral	-0.6	neutral	-0.56	low_impact	0.96	0.92	neutral	0.91	neutral	1.61	13.88	neutral	0.24	0.45	0.41	neutral	0.08	neutral	0.36	neutral	0.28	neutral	4	0.59	neutral	0.7	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.11	medium_impact	-0.34	medium_impact	0.49	0.8	NA	NA	0.49	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5463	5463	C	T	MI.14856	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	994	332	L	F	Ctt/Ttt	-14.45	0	0	benign	0.07	neutral	0.71	neutral	1.68	neutral	-2.23	neutral	-2.38	low_impact	1.77	0.96	neutral	0.8	neutral	3.95	23.60	deleterious	0.23	0.45	0.64	disease	0.31	neutral	0.48	neutral	0.61	disease	2	0.2	neutral	0.82	deleterious	-6	neutral	0.31	neutral	0.23	medium_impact	0.42	medium_impact	0.35	medium_impact	0.51	0.8	NA	NA	0.27	N	0.36	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5463	5463	C	G	MI.14857	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	994	332	L	V	Ctt/Gtt	-14.45	0	0	benign	0.01	neutral	0.5	neutral	1.67	neutral	-2.35	neutral	-1.2	medium_impact	2.12	0.87	neutral	0.94	neutral	2.17	17.30	deleterious	0.24	0.45	0.4	neutral	0.21	neutral	0.46	neutral	0.41	neutral	2	0.49	neutral	0.75	deleterious	-3	neutral	0.16	neutral	1.03	medium_impact	0.21	medium_impact	0.64	medium_impact	0.33	0.8	NA	NA	0.43	N	0.29	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5464	5464	T	G	MI.14858	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	995	332	L	R	cTt/cGt	-8.2	0	0	benign	0.03	neutral	0.35	neutral	1.59	deleterious	-5.06	deleterious	-4.37	medium_impact	2.92	0.82	neutral	0.43	neutral	4.24	23.90	deleterious	0.09	0.35	0.89	disease	0.68	disease	0.76	disease	0.78	disease	6	0.63	neutral	0.66	deleterious	-3	neutral	0.42	neutral	0.59	medium_impact	0.06	medium_impact	1.31	medium_impact	0.25	0.8	NA	NA	0.35	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5464	5464	T	A	MI.14859	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	995	332	L	H	cTt/cAt	-8.2	0	0	benign	0.19	neutral	0.54	neutral	1.59	deleterious	-5.59	deleterious	-4.93	medium_impact	2.92	0.81	neutral	0.49	neutral	4.16	23.80	deleterious	0.11	0.4	0.92	disease	0.54	disease	0.73	disease	0.79	disease	6	0.35	neutral	0.68	deleterious	-3	neutral	0.56	deleterious	-0.22	medium_impact	0.25	medium_impact	1.31	medium_impact	0.24	0.8	NA	NA	0.28	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8385	8385	C	G	MI.1486	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	20	7	T	S	aCc/aGc	-0.8	0	0	benign	0.01	neutral	0.84	neutral	2.18	neutral	2.3	neutral	1.84	neutral_impact	-1.11	0.93	neutral	0.94	neutral	-1.19	0.01	neutral	0.37202141	0.85	0.1	neutral	0.01	neutral	0.34	neutral	0.08	neutral	8	0.13	neutral	0.92	deleterious	-6	neutral	0.09	neutral	1.14	medium_impact	0.7	medium_impact	-2.05	low_impact	0.64	0.85	5.88	6.93	0.34	N	0.05	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5464	5464	T	C	MI.14860	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	995	332	L	P	cTt/cCt	-8.2	0	0	benign	0.04	neutral	0.2	neutral	1.62	deleterious	-3.52	deleterious	-4.95	medium_impact	2.58	0.79	neutral	0.48	neutral	3.91	23.50	deleterious	0.1	0.4	0.92	disease	0.67	disease	0.76	disease	0.8	disease	6	0.79	neutral	0.58	deleterious	-3	neutral	0.43	neutral	0.47	medium_impact	-0.13	medium_impact	1.03	medium_impact	0.23	0.8	NA	NA	0.33	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5466	5466	A	C	MI.14861	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	997	333	T	P	Acc/Ccc	-5.66	0	0.01	benign	0.06	neutral	0.28	neutral	1.87	neutral	-2.06	neutral	-2.43	low_impact	1.76	0.84	neutral	0.44	neutral	3.46	23.00	deleterious	0.09	0.35	0.76	disease	0.8	disease	0.77	disease	0.81	disease	6	0.69	neutral	0.61	deleterious	-6	neutral	0.48	deleterious	0.3	medium_impact	-0.02	medium_impact	0.34	medium_impact	0.40	0.8	NA	NA	0.31	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5466	5466	A	T	MI.14862	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	997	333	T	S	Acc/Tcc	-5.66	0	0.01	benign	0	neutral	0.61	neutral	2.6	neutral	2.51	neutral	1.89	neutral_impact	-2.05	0.78	neutral	0.9	neutral	0.41	6.74	deleterious	0.32	0.5	0.36	neutral	0.03	neutral	0.35	neutral	0.17	neutral	7	0.39	neutral	0.81	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.32	medium_impact	-2.87	low_impact	0.46	0.8	NA	NA	0.34	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5466	5466	A	G	MI.14863	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	997	333	T	A	Acc/Gcc	-5.66	0	0.01	benign	0.01	neutral	0.72	neutral	2.1	neutral	0.72	neutral	-0.65	neutral_impact	0.03	0.98	neutral	0.85	neutral	2.17	17.33	deleterious	0.22	0.45	0.42	neutral	0.19	neutral	0.42	neutral	0.35	neutral	3	0.26	neutral	0.86	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	0.44	medium_impact	-1.12	low_impact	0.17	0.8	NA	NA	0.3	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5467	5467	C	A	MI.14864	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	998	333	T	N	aCc/aAc	-0.11	0	0	benign	0.02	neutral	0.34	neutral	1.89	neutral	-1.68	neutral	-0.68	low_impact	1.76	0.84	neutral	0.56	neutral	3.56	23.10	deleterious	0.3	0.45	0.59	disease	0.67	disease	0.66	disease	0.73	disease	5	0.65	neutral	0.66	deleterious	-6	neutral	0.29	neutral	0.75	medium_impact	0.05	medium_impact	0.34	medium_impact	0.44	0.8	NA	NA	0.29	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5467	5467	C	T	MI.14865	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	998	333	T	I	aCc/aTc	-0.11	0	0	benign	0.06	neutral	0.7	neutral	1.87	neutral	-2.44	deleterious	-3.24	low_impact	0.87	0.86	neutral	0.52	neutral	3.96	23.60	deleterious	0.14	0.4	0.57	disease	0.58	disease	0.63	disease	0.71	disease	4	0.22	neutral	0.82	deleterious	-6	neutral	0.39	neutral	0.3	medium_impact	0.41	medium_impact	-0.41	medium_impact	0.22	0.8	NA	NA	0.2	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5467	5467	C	G	MI.14866	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	998	333	T	S	aCc/aGc	-0.11	0	0	benign	0	neutral	0.61	neutral	2.6	neutral	2.51	neutral	1.89	neutral_impact	-2.05	0.78	neutral	0.9	neutral	0.63	8.33	deleterious	0.32	0.5	0.36	neutral	0.03	neutral	0.35	neutral	0.17	neutral	7	0.39	neutral	0.81	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.32	medium_impact	-2.87	low_impact	0.46	0.8	NA	NA	0.34	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5469	5469	A	G	MI.14867	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1000	334	T	A	Acg/Gcg	-12.83	0	0	benign	0.05	neutral	0.55	neutral	1.78	neutral	-2.11	deleterious	-4.05	medium_impact	2.12	0.86	neutral	0.72	neutral	3.18	22.70	deleterious	0.29	0.45	0.43	neutral	0.24	neutral	0.42	neutral	0.45	neutral	1	0.4	neutral	0.75	deleterious	-3	neutral	0.28	neutral	0.37	medium_impact	0.26	medium_impact	0.64	medium_impact	0.19	0.8	4.9	8.12	0.35	N	0.57	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5469	5469	A	C	MI.14868	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1000	334	T	P	Acg/Ccg	-12.83	0	0	benign	0.28	neutral	0.25	neutral	1.73	deleterious	-4.42	deleterious	-5.09	medium_impact	2.43	0.78	neutral	0.1	damaging	3.47	23.00	deleterious	0.11	0.4	0.9	disease	0.77	disease	0.71	disease	0.8	disease	6	0.7	neutral	0.49	deleterious	-3	neutral	0.66	deleterious	-0.42	medium_impact	-0.06	medium_impact	0.9	medium_impact	0.39	0.8	4.9	8.12	0.23	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5469	5469	A	T	MI.14869	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1000	334	T	S	Acg/Tcg	-12.83	0	0	benign	0.01	neutral	0.52	neutral	1.79	neutral	-1.97	deleterious	-3.14	low_impact	1.94	0.85	neutral	0.9	neutral	1.81	15.04	deleterious	0.37	0.5	0.38	neutral	0.31	neutral	0.41	neutral	0.46	neutral	1	0.47	neutral	0.76	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	0.23	medium_impact	0.49	medium_impact	0.48	0.8	4.9	8.12	0.37	N	0.52	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8385	8385	C	T	MI.1487	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	20	7	T	I	aCc/aTc	-0.8	0	0	benign	0.03	neutral	0.67	neutral	2.02	neutral	-2.75	deleterious	-3.23	medium_impact	1.98	0.99	neutral	0.56	neutral	2.01	16.29	deleterious	0.37006987	0.85	0.59	disease	0.17	neutral	0.55	disease	0.18	neutral	6	0.29	neutral	0.82	deleterious	-3	neutral	0.21	neutral	0.68	medium_impact	0.47	medium_impact	0.6	medium_impact	0.43	0.85	5.88	6.93	0.36	N	0.48	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5470	5470	C	T	MI.14870	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1001	334	T	M	aCg/aTg	0.13	0	0	possibly_damaging	0.65	neutral	0.29	neutral	1.79	neutral	-1.96	deleterious	-4.61	medium_impact	2.43	0.9	neutral	0.23	damaging	4.05	23.70	deleterious	0.15	0.45	0.63	disease	0.45	neutral	0.44	neutral	0.62	disease	2	0.75	neutral	0.32	neutral	0	NA	0.62	deleterious	-1.04	low_impact	-0.01	medium_impact	0.9	medium_impact	0.46	0.8	4.9	8.12	0.44	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5470	5470	C	A	MI.14871	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1001	334	T	K	aCg/aAg	0.13	0	0	benign	0.11	neutral	0.31	neutral	1.73	deleterious	-4.4	deleterious	-5	medium_impact	3.33	0.85	neutral	0.11	damaging	4.39	24.10	deleterious	0.13	0.4	0.8	disease	0.72	disease	0.76	disease	0.81	disease	6	0.65	neutral	0.6	deleterious	-3	neutral	0.53	deleterious	0.03	medium_impact	0.02	medium_impact	1.66	medium_impact	0.42	0.8	4.9	8.12	0.36	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5472	5472	C	A	MI.14872	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1003	335	L	M	Cta/Ata	-6.12	0	0	possibly_damaging	0.58	neutral	0.39	neutral	1.85	neutral	-0.84	neutral	0.17	neutral_impact	0.1	0.84	neutral	0.91	neutral	1.10	11.22	neutral	0.15	0.4	0.69	disease	0.03	neutral	0.27	neutral	0.3	neutral	4	0.63	neutral	0.41	neutral	-3	neutral	0.57	deleterious	-0.93	medium_impact	0.1	medium_impact	-1.06	low_impact	0.48	0.8	NA	NA	0.45	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5472	5472	C	G	MI.14873	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1003	335	L	V	Cta/Gta	-6.12	0	0	benign	0.1	neutral	0.11	neutral	1.73	neutral	-2	neutral	-1.89	medium_impact	2.46	0.88	neutral	0.7	neutral	3.32	22.90	deleterious	0.16	0.45	0.72	disease	0.26	neutral	0.53	disease	0.59	disease	2	0.88	neutral	0.51	deleterious	-3	neutral	0.42	neutral	0.08	medium_impact	-0.3	medium_impact	0.93	medium_impact	0.42	0.8	NA	NA	0.45	N	0.31	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5473	5473	T	A	MI.14874	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1004	335	L	Q	cTa/cAa	-5.66	0	0	possibly_damaging	0.67	neutral	0.11	neutral	1.64	deleterious	-5.01	deleterious	-3.91	medium_impact	3.16	0.86	neutral	0.52	neutral	4.12	23.80	deleterious	0.09	0.35	0.95	disease	0.5	neutral	0.64	disease	0.82	disease	6	0.9	neutral	0.22	neutral	0	NA	0.72	deleterious	-1.08	low_impact	-0.3	medium_impact	1.52	medium_impact	0.32	0.8	NA	NA	0.44	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5473	5473	T	G	MI.14875	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1004	335	L	R	cTa/cGa	-5.66	0	0	possibly_damaging	0.67	neutral	0.11	neutral	1.64	deleterious	-4.83	deleterious	-4.3	medium_impact	3.16	0.85	neutral	0.45	neutral	4.22	23.90	deleterious	0.07	0.35	0.91	disease	0.75	disease	0.75	disease	0.83	disease	7	0.9	neutral	0.22	neutral	0	NA	0.78	deleterious	-1.08	low_impact	-0.3	medium_impact	1.52	medium_impact	0.28	0.8	NA	NA	0.38	N	0.91	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5473	5473	T	C	MI.14876	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1004	335	L	P	cTa/cCa	-5.66	0	0	possibly_damaging	0.67	deleterious	0.04	neutral	1.64	deleterious	-5.41	deleterious	-5.22	medium_impact	2.82	0.79	neutral	0.36	neutral	3.97	23.60	deleterious	0.07	0.35	0.96	disease	0.73	disease	0.76	disease	0.86	disease	7	0.96	neutral	0.19	neutral	4	deleterious	0.79	deleterious	-1.08	low_impact	-0.56	medium_impact	1.23	medium_impact	0.33	0.8	NA	NA	0.29	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5475	5475	C	T	MI.14877	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1006	336	L	F	Ctc/Ttc	-5.89	0	0	probably_damaging	0.98	neutral	0.2	neutral	1.6	deleterious	-3.14	neutral	-1.86	medium_impact	2.92	0.94	neutral	0.74	neutral	3.96	23.60	deleterious	0.26	0.45	0.63	disease	0.36	neutral	0.59	disease	0.62	disease	2	0.99	deleterious	0.11	neutral	1	deleterious	0.72	deleterious	-2.34	low_impact	-0.13	medium_impact	1.31	medium_impact	0.48	0.8	5.48	8.52	0.5	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5475	5475	C	A	MI.14878	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1006	336	L	I	Ctc/Atc	-5.89	0	0	probably_damaging	0.93	neutral	0.34	neutral	1.68	neutral	-1.88	neutral	-0.26	low_impact	1.56	0.92	neutral	0.9	neutral	2.65	20.50	deleterious	0.26	0.45	0.45	neutral	0.24	neutral	0.4	neutral	0.43	neutral	1	0.94	neutral	0.21	neutral	-2	neutral	0.65	deleterious	-1.83	low_impact	0.05	medium_impact	0.17	medium_impact	0.39	0.8	5.48	8.52	0.48	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5475	5475	C	G	MI.14879	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1006	336	L	V	Ctc/Gtc	-5.89	0	0	possibly_damaging	0.89	neutral	0.11	neutral	1.63	neutral	-2.6	neutral	-0.41	medium_impact	2.71	0.92	neutral	0.7	neutral	3.26	22.80	deleterious	0.22	0.45	0.46	neutral	0.33	neutral	0.58	disease	0.48	neutral	1	0.96	neutral	0.11	neutral	0	NA	0.66	deleterious	-1.63	low_impact	-0.3	medium_impact	1.14	medium_impact	0.34	0.8	5.48	8.52	0.54	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8385	8385	C	A	MI.1488	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	20	7	T	N	aCc/aAc	-0.8	0	0	benign	0.05	neutral	0.52	neutral	1.98	neutral	-2.16	neutral	-0.84	neutral_impact	0.7	0.99	neutral	0.68	neutral	1.67	14.23	neutral	0.42207444	0.85	0.5	neutral	0.17	neutral	0.51	disease	0.19	neutral	6	0.43	neutral	0.74	deleterious	-6	neutral	0.20	neutral	0.46	medium_impact	0.31	medium_impact	-0.5	medium_impact	0.70	0.85	5.88	6.93	0.43	N	0.14	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5476	5476	T	C	MI.14880	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1007	336	L	P	cTc/cCc	-1.03	0	0	probably_damaging	0.99	neutral	0.13	neutral	1.55	deleterious	-5.76	deleterious	-3.05	high_impact	3.61	0.85	neutral	0.41	neutral	4.02	23.60	deleterious	0.11	0.4	0.84	disease	0.67	disease	0.77	disease	0.8	disease	6	0.99	deleterious	0.07	neutral	2	deleterious	0.81	deleterious	-2.62	low_impact	-0.25	medium_impact	1.89	medium_impact	0.30	0.8	5.48	8.52	0.45	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5476	5476	T	G	MI.14881	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1007	336	L	R	cTc/cGc	-1.03	0	0	probably_damaging	0.98	deleterious	0.04	neutral	1.56	deleterious	-5.16	deleterious	-2.73	high_impact	3.61	0.87	neutral	0.44	neutral	4.25	23.90	deleterious	0.1	0.4	0.77	disease	0.77	disease	0.77	disease	0.79	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-2.34	low_impact	-0.56	medium_impact	1.89	medium_impact	0.28	0.8	5.48	8.52	0.47	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5476	5476	T	A	MI.14882	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1007	336	L	H	cTc/cAc	-1.03	0	0	probably_damaging	0.99	neutral	0.06	neutral	1.55	deleterious	-5.71	deleterious	-3.32	high_impact	3.61	0.89	neutral	0.45	neutral	4.39	24.10	deleterious	0.13	0.4	0.83	disease	0.63	disease	0.74	disease	0.76	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.77	deleterious	-2.62	low_impact	-0.46	medium_impact	1.89	medium_impact	0.28	0.8	5.48	8.52	0.5	N	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5478	5478	C	A	MI.14883	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1009	337	L	M	Cta/Ata	-10.28	0	0	probably_damaging	0.98	neutral	0.23	neutral	1.27	deleterious	-3.38	neutral	-1.8	medium_impact	3.21	0.93	neutral	0.61	neutral	3.78	23.40	deleterious	0.16	0.45	0.8	disease	0.33	neutral	0.49	neutral	0.59	disease	2	0.99	deleterious	0.13	neutral	1	deleterious	0.73	deleterious	-2.34	low_impact	-0.08	medium_impact	1.56	medium_impact	0.45	0.8	NA	NA	0.5	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5478	5478	C	G	MI.14884	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1009	337	L	V	Cta/Gta	-10.28	0	0	possibly_damaging	0.89	neutral	0.5	neutral	1.26	deleterious	-3.48	deleterious	-2.54	high_impact	4.01	0.87	neutral	0.16	damaging	3.32	22.90	deleterious	0.19	0.45	0.81	disease	0.42	neutral	0.71	disease	0.67	disease	3	0.88	neutral	0.31	neutral	1	deleterious	0.73	deleterious	-1.63	low_impact	0.21	medium_impact	2.23	high_impact	0.47	0.8	NA	NA	0.37	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5479	5479	T	C	MI.14885	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1010	337	L	P	cTa/cCa	0.13	0.01	0	probably_damaging	0.99	neutral	0.26	neutral	1.19	deleterious	-5.41	deleterious	-6.47	high_impact	3.66	0.94	neutral	0.15	damaging	3.95	23.60	deleterious	0.07	0.35	0.96	disease	0.67	disease	0.7	disease	0.83	disease	7	0.99	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-2.62	low_impact	-0.04	medium_impact	1.94	medium_impact	0.18	0.8	NA	NA	0.42	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5479	5479	T	A	MI.14886	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1010	337	L	Q	cTa/cAa	0.13	0.01	0	probably_damaging	0.99	neutral	0.29	neutral	1.18	deleterious	-6.6	deleterious	-5.6	high_impact	4.01	0.89	neutral	0.14	damaging	4.11	23.80	deleterious	0.1	0.4	0.95	disease	0.64	disease	0.72	disease	0.84	disease	7	0.99	deleterious	0.15	neutral	2	deleterious	0.80	deleterious	-2.62	low_impact	-0.01	medium_impact	2.23	high_impact	0.23	0.8	NA	NA	0.44	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5479	5479	T	G	MI.14887	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1010	337	L	R	cTa/cGa	0.13	0.01	0	probably_damaging	0.98	neutral	0.35	neutral	1.18	deleterious	-6.43	deleterious	-5.6	high_impact	4.01	0.88	neutral	0.12	damaging	4.24	23.90	deleterious	0.06	0.35	0.94	disease	0.8	disease	0.8	disease	0.89	disease	8	0.98	deleterious	0.19	neutral	2	deleterious	0.86	deleterious	-2.34	low_impact	0.06	medium_impact	2.23	high_impact	0.26	0.8	NA	NA	0.45	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5481	5481	C	A	MI.14888	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1012	338	P	T	Cct/Act	-15.37	0	0	probably_damaging	0.99	neutral	0.38	neutral	1.2	deleterious	-4.08	deleterious	-7.59	high_impact	3.98	0.83	neutral	0.11	damaging	3.76	23.30	deleterious	0.18	0.45	0.68	disease	0.57	disease	0.75	disease	0.76	disease	5	0.99	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-2.62	low_impact	0.09	medium_impact	2.21	high_impact	0.62	0.8	NA	NA	0.34	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5481	5481	C	G	MI.14889	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1012	338	P	A	Cct/Gct	-15.37	0	0	probably_damaging	0.98	neutral	0.55	neutral	1.18	deleterious	-4.69	deleterious	-7.59	medium_impact	3.29	0.85	neutral	0.15	damaging	3.08	22.50	deleterious	0.21	0.45	0.66	disease	0.43	neutral	0.75	disease	0.64	disease	3	0.98	neutral	0.29	neutral	1	deleterious	0.72	deleterious	-2.34	low_impact	0.26	medium_impact	1.63	medium_impact	0.57	0.8	NA	NA	0.26	N	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8387	8387	G	T	MI.1489	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	22	8	V	L	Gta/Tta	-9.59	0	0	probably_damaging	0.96	neutral	0.67	neutral	1.99	neutral	-0.4	neutral	-1.28	low_impact	1.1	0.99	neutral	0.54	neutral	3.37	22.90	deleterious	0.66698427	0.85	0.26	neutral	0.15	neutral	0.47	neutral	0.16	neutral	7	0.95	neutral	0.36	neutral	-2	neutral	0.63	deleterious	-2.07	low_impact	0.47	medium_impact	-0.16	medium_impact	0.63	0.85	2.94	7.06	0.37	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5481	5481	C	T	MI.14890	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1012	338	P	S	Cct/Tct	-15.37	0	0	probably_damaging	0.99	neutral	0.45	neutral	1.2	deleterious	-4.06	deleterious	-7.59	medium_impact	3.44	0.86	neutral	0.14	damaging	3.94	23.50	deleterious	0.22	0.45	0.47	neutral	0.62	disease	0.74	disease	0.73	disease	5	0.99	deleterious	0.23	neutral	1	deleterious	0.72	deleterious	-2.62	low_impact	0.16	medium_impact	1.75	medium_impact	0.16	0.8	NA	NA	0.3	N	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5482	5482	C	A	MI.14891	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1013	338	P	H	cCt/cAt	4.29	0.98	0	probably_damaging	0.99	neutral	0.52	neutral	1.14	deleterious	-6.89	deleterious	-8.54	high_impact	3.63	0.85	neutral	0.09	damaging	4.14	23.80	deleterious	0.15	0.4	0.9	disease	0.76	disease	0.82	disease	0.84	disease	7	0.99	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-2.62	low_impact	0.23	medium_impact	1.91	medium_impact	0.35	0.8	NA	NA	0.59	P	0.71	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5482	5482	C	G	MI.14892	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1013	338	P	R	cCt/cGt	4.29	0.98	0	probably_damaging	0.99	neutral	0.33	neutral	1.14	deleterious	-6.34	deleterious	-8.54	high_impact	3.98	0.87	neutral	0.12	damaging	3.60	23.20	deleterious	0.13	0.4	0.8	disease	0.83	disease	0.83	disease	0.85	disease	7	0.99	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-2.62	low_impact	0.04	medium_impact	2.21	high_impact	0.48	0.8	NA	NA	0.65	P	0.56	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5482	5482	C	T	MI.14893	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1013	338	P	L	cCt/cTt	4.29	0.98	0	probably_damaging	0.99	neutral	0.95	neutral	1.27	deleterious	-3.05	deleterious	-9.48	high_impact	3.63	0.92	neutral	0.11	damaging	4.30	24.00	deleterious	0.15	0.45	0.62	disease	0.78	disease	0.72	disease	0.74	disease	5	0.99	deleterious	0.48	deleterious	2	deleterious	0.76	deleterious	-2.62	low_impact	0.92	medium_impact	1.91	medium_impact	0.54	0.8	NA	NA	0.49	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5484	5484	A	T	MI.14894	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1015	339	I	F	Atc/Ttc	-10.98	0	0	benign	0.28	neutral	0.78	neutral	1.75	neutral	-2.1	neutral	-1.94	medium_impact	2.12	0.85	neutral	0.5	neutral	3.66	23.20	deleterious	0.14	0.4	0.52	disease	0.51	disease	0.71	disease	0.73	disease	5	0.18	neutral	0.75	deleterious	-3	neutral	0.55	deleterious	-0.42	medium_impact	0.51	medium_impact	0.64	medium_impact	0.57	0.8	NA	NA	0.22	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5484	5484	A	C	MI.14895	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1015	339	I	L	Atc/Ctc	-10.98	0	0	benign	0.02	neutral	1	neutral	2.22	neutral	0.86	neutral	1.21	neutral_impact	-1.22	0.9	neutral	0.9	neutral	-0.61	0.12	neutral	0.19	0.45	0.37	neutral	0.11	neutral	0.27	neutral	0.22	neutral	6	0.02	neutral	0.99	deleterious	-6	neutral	0.15	neutral	0.75	medium_impact	1.87	high_impact	-2.17	low_impact	0.47	0.8	NA	NA	0.33	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5484	5484	A	G	MI.14896	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1015	339	I	V	Atc/Gtc	-10.98	0	0	benign	0	neutral	0.63	neutral	1.77	neutral	-1.78	neutral	-0.7	low_impact	1.26	0.95	neutral	0.84	neutral	0.23	5.02	deleterious	0.2	0.45	0.46	neutral	0.17	neutral	0.43	neutral	0.31	neutral	4	0.37	neutral	0.82	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.34	medium_impact	-0.08	medium_impact	0.35	0.8	NA	NA	0.36	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5485	5485	T	G	MI.14897	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1016	339	I	S	aTc/aGc	-2.19	0	0	benign	0.28	neutral	0.56	neutral	1.74	neutral	-2.23	deleterious	-3.56	medium_impact	2.46	0.85	neutral	0.54	neutral	4.04	23.70	deleterious	0.09	0.35	0.63	disease	0.56	disease	0.67	disease	0.72	disease	4	0.34	neutral	0.64	deleterious	-3	neutral	0.50	deleterious	-0.42	medium_impact	0.27	medium_impact	0.93	medium_impact	0.34	0.8	NA	NA	0.23	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5485	5485	T	C	MI.14898	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1016	339	I	T	aTc/aCc	-2.19	0	0	benign	0.11	neutral	0.62	neutral	1.76	neutral	-2.01	deleterious	-2.74	medium_impact	2.12	0.85	neutral	0.59	neutral	1.91	15.63	deleterious	0.16	0.45	0.41	neutral	0.31	neutral	0.61	disease	0.5	neutral	0	0.28	neutral	0.76	deleterious	-3	neutral	0.38	neutral	0.03	medium_impact	0.33	medium_impact	0.64	medium_impact	0.31	0.8	NA	NA	0.27	N	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5485	5485	T	A	MI.14899	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1016	339	I	N	aTc/aAc	-2.19	0	0	possibly_damaging	0.56	neutral	0.27	neutral	1.68	deleterious	-5.02	deleterious	-4.51	medium_impact	2.46	0.86	neutral	0.47	neutral	4.30	24.00	deleterious	0.19	0.45	0.83	disease	0.59	disease	0.69	disease	0.74	disease	5	0.73	neutral	0.36	neutral	0	NA	0.66	deleterious	-0.89	medium_impact	-0.03	medium_impact	0.93	medium_impact	0.32	0.8	NA	NA	0.35	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8596	8596	A	T	MI.149	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	70	24	I	F	Att/Ttt	-7.51	0	0	probably_damaging	0.99	deleterious	0.03	neutral	4.07	neutral	-1.56	deleterious	-2.98	low_impact	1.17	0.87	neutral	0.6	neutral	3.48	23.10	deleterious	0.4	0.65	0.47	neutral	0.52	disease	0.41	neutral	0.5	neutral	0	1	deleterious	0.02	neutral	2	deleterious	0.72	deleterious	-2.65	low_impact	-0.56	medium_impact	-0.1	medium_impact	0.58	0.9	18.14	17.22	0.43	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8387	8387	G	C	MI.1490	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	22	8	V	L	Gta/Cta	-9.59	0	0	probably_damaging	0.96	neutral	0.67	neutral	1.99	neutral	-0.4	neutral	-1.28	low_impact	1.1	0.99	neutral	0.54	neutral	3.26	22.80	deleterious	0.66698427	0.85	0.26	neutral	0.15	neutral	0.47	neutral	0.16	neutral	7	0.95	neutral	0.36	neutral	-2	neutral	0.63	deleterious	-2.07	low_impact	0.47	medium_impact	-0.16	medium_impact	0.63	0.85	2.94	7.06	0.37	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5486	5486	C	A	MI.14900	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1017	339	I	M	atC/atA	2.9	0.13	0	possibly_damaging	0.46	neutral	0.31	neutral	1.8	neutral	-1.38	neutral	0.36	low_impact	1.18	0.94	neutral	0.92	neutral	2.36	18.54	deleterious	0.23	0.45	0.47	neutral	0.2	neutral	0.36	neutral	0.36	neutral	3	0.65	neutral	0.43	neutral	-3	neutral	0.54	deleterious	-0.73	medium_impact	0.02	medium_impact	-0.15	medium_impact	0.55	0.8	NA	NA	0.51	N	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5486	5486	C	G	MI.14901	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1017	339	I	M	atC/atG	2.9	0.13	0	possibly_damaging	0.46	neutral	0.31	neutral	1.8	neutral	-1.38	neutral	0.36	low_impact	1.18	0.94	neutral	0.92	neutral	1.96	15.96	deleterious	0.23	0.45	0.47	neutral	0.2	neutral	0.36	neutral	0.36	neutral	3	0.65	neutral	0.43	neutral	-3	neutral	0.54	deleterious	-0.73	medium_impact	0.02	medium_impact	-0.15	medium_impact	0.55	0.8	NA	NA	0.51	N	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5487	5487	T	C	MI.14902	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1018	340	S	P	Tcc/Ccc	-12.83	0	0	benign	0.22	neutral	0.26	neutral	1.86	deleterious	-3.96	deleterious	-2.52	low_impact	1.65	0.75	neutral	0.39	neutral	3.80	23.40	deleterious	0.13	0.4	0.73	disease	0.78	disease	0.67	disease	0.76	disease	5	0.69	neutral	0.52	deleterious	-6	neutral	0.52	deleterious	-0.29	medium_impact	-0.04	medium_impact	0.24	medium_impact	0.25	0.8	NA	NA	0.29	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5487	5487	T	G	MI.14903	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1018	340	S	A	Tcc/Gcc	-12.83	0	0	benign	0.02	neutral	0.52	neutral	2.01	neutral	0.06	neutral	-0.76	low_impact	0.88	0.97	neutral	0.97	neutral	0.77	9.29	deleterious	0.19	0.45	0.49	neutral	0.2	neutral	0.48	neutral	0.33	neutral	3	0.45	neutral	0.75	deleterious	-6	neutral	0.18	neutral	0.75	medium_impact	0.23	medium_impact	-0.4	medium_impact	0.33	0.8	NA	NA	0.35	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5487	5487	T	A	MI.14904	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1018	340	S	T	Tcc/Acc	-12.83	0	0	benign	0	neutral	0.45	neutral	2.23	neutral	1.46	neutral	1.1	neutral_impact	-0.27	0.89	neutral	0.94	neutral	-0.44	0.31	neutral	0.19	0.45	0.36	neutral	0.04	neutral	0.34	neutral	0.17	neutral	7	0.55	neutral	0.73	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.16	medium_impact	-1.37	low_impact	0.46	0.8	NA	NA	0.45	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5488	5488	C	A	MI.14905	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1019	340	S	Y	tCc/tAc	-1.26	0	0	possibly_damaging	0.47	neutral	1	neutral	1.9	neutral	-1.79	deleterious	-3.25	medium_impact	2.9	0.89	neutral	0.55	neutral	4.11	23.70	deleterious	0.1	0.4	0.61	disease	0.61	disease	0.7	disease	0.74	disease	5	0.47	neutral	0.77	deleterious	0	NA	0.59	deleterious	-0.75	medium_impact	1.87	high_impact	1.3	medium_impact	0.23	0.8	NA	NA	0.25	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5488	5488	C	G	MI.14906	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1019	340	S	C	tCc/tGc	-1.26	0	0	possibly_damaging	0.57	neutral	0.18	neutral	1.86	deleterious	-3.74	neutral	-2.26	medium_impact	2.9	0.8	neutral	0.43	neutral	3.68	23.30	deleterious	0.11	0.4	0.93	disease	0.57	disease	0.67	disease	0.8	disease	6	0.81	neutral	0.31	neutral	0	NA	0.62	deleterious	-0.91	medium_impact	-0.16	medium_impact	1.3	medium_impact	0.28	0.8	NA	NA	0.32	N	0.55	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5488	5488	C	T	MI.14907	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1019	340	S	F	tCc/tTc	-1.26	0	0	possibly_damaging	0.47	neutral	0.71	neutral	1.89	neutral	-1.89	deleterious	-3.16	medium_impact	2.9	0.87	neutral	0.54	neutral	4.25	23.90	deleterious	0.1	0.4	0.88	disease	0.65	disease	0.7	disease	0.75	disease	5	0.37	neutral	0.62	deleterious	0	NA	0.64	deleterious	-0.75	medium_impact	0.42	medium_impact	1.3	medium_impact	0.20	0.8	NA	NA	0.24	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5490	5490	C	A	MI.14908	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1021	341	P	T	Cct/Act	-2.42	0	0	probably_damaging	0.99	neutral	0.4	neutral	0.48	deleterious	-5.3	deleterious	-7.28	medium_impact	3.33	0.85	neutral	0.11	damaging	3.78	23.40	deleterious	0.21	0.45	0.63	disease	0.44	neutral	0.74	disease	0.62	disease	2	0.99	deleterious	0.21	neutral	1	deleterious	0.74	deleterious	-2.62	low_impact	0.11	medium_impact	1.66	medium_impact	0.57	0.8	NA	NA	0.31	N	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5490	5490	C	G	MI.14909	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1021	341	P	A	Cct/Gct	-2.42	0	0	probably_damaging	0.98	neutral	0.51	neutral	0.46	deleterious	-5.78	deleterious	-7.52	medium_impact	3.19	0.87	neutral	0.14	damaging	3.09	22.50	deleterious	0.16	0.45	0.62	disease	0.3	neutral	0.78	disease	0.64	disease	3	0.98	neutral	0.27	neutral	1	deleterious	0.71	deleterious	-2.34	low_impact	0.22	medium_impact	1.54	medium_impact	0.64	0.8	NA	NA	0.4	N	0.48	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8387	8387	G	A	MI.1491	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	22	8	V	M	Gta/Ata	-9.59	0	0	probably_damaging	1	neutral	0.34	neutral	1.96	neutral	-1.67	neutral	-1.12	neutral_impact	0.55	0.98	neutral	0.69	neutral	2.35	18.52	deleterious	0.58788784	0.85	0.42	neutral	0.14	neutral	0.44	neutral	0.16	neutral	7	1	deleterious	0.17	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.13	medium_impact	-0.63	medium_impact	0.64	0.85	2.94	7.06	0.52	N	0.44	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5490	5490	C	T	MI.14910	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1021	341	P	S	Cct/Tct	-2.42	0	0	probably_damaging	0.99	neutral	0.4	neutral	0.6	deleterious	-3.75	deleterious	-7.52	medium_impact	3.19	0.93	neutral	0.18	damaging	3.94	23.50	deleterious	0.18	0.45	0.55	disease	0.45	neutral	0.74	disease	0.62	disease	2	0.99	deleterious	0.21	neutral	1	deleterious	0.72	deleterious	-2.62	low_impact	0.11	medium_impact	1.54	medium_impact	0.37	0.8	NA	NA	0.41	N	0.45	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5491	5491	C	A	MI.14911	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1022	341	P	H	cCt/cAt	2.21	0.92	0	probably_damaging	0.99	neutral	0.53	neutral	0.41	deleterious	-9.54	deleterious	-8.45	high_impact	3.54	0.86	neutral	0.08	damaging	4.08	23.70	deleterious	0.14	0.4	0.8	disease	0.62	disease	0.82	disease	0.78	disease	6	0.99	deleterious	0.27	neutral	2	deleterious	0.78	deleterious	-2.62	low_impact	0.24	medium_impact	1.84	medium_impact	0.35	0.8	NA	NA	0.45	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5491	5491	C	T	MI.14912	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1022	341	P	L	cCt/cTt	2.21	0.92	0	probably_damaging	0.99	neutral	0.67	neutral	0.43	deleterious	-6.86	deleterious	-9.11	high_impact	3.54	0.92	neutral	0.1	damaging	4.36	24.10	deleterious	0.18	0.45	0.78	disease	0.62	disease	0.76	disease	0.77	disease	5	0.99	deleterious	0.34	neutral	2	deleterious	0.76	deleterious	-2.62	low_impact	0.38	medium_impact	1.84	medium_impact	0.59	0.8	NA	NA	0.46	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5491	5491	C	G	MI.14913	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1022	341	P	R	cCt/cGt	2.21	0.92	0	probably_damaging	0.99	neutral	0.34	neutral	0.41	deleterious	-8.55	deleterious	-8.45	high_impact	3.88	0.88	neutral	0.1	damaging	3.69	23.30	deleterious	0.14	0.4	0.64	disease	0.7	disease	0.84	disease	0.79	disease	6	0.99	deleterious	0.18	neutral	2	deleterious	0.78	deleterious	-2.62	low_impact	0.05	medium_impact	2.12	high_impact	0.48	0.8	NA	NA	0.55	P	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5493	5493	T	G	MI.14914	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1024	342	F	V	Ttt/Gtt	-8.66	0	0	benign	0.01	neutral	0.37	neutral	2.08	neutral	1.47	neutral	0.82	neutral_impact	-0.98	0.88	neutral	0.73	neutral	4.11	23.70	deleterious	0.15	0.4	0.68	disease	0.22	neutral	0.55	disease	0.51	disease	0	0.62	neutral	0.68	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.08	medium_impact	-1.97	low_impact	0.39	0.8	NA	NA	0.39	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5493	5493	T	C	MI.14915	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1024	342	F	L	Ttt/Ctt	-8.66	0	0	benign	0	neutral	1	neutral	2.37	neutral	3.25	neutral	1.46	neutral_impact	-2.2	0.98	neutral	0.98	neutral	1.01	10.70	neutral	0.18	0.45	0.57	disease	0.07	neutral	0.34	neutral	0.28	neutral	4	0	neutral	1	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	1.87	high_impact	-3	low_impact	0.55	0.8	NA	NA	0.35	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5493	5493	T	A	MI.14916	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1024	342	F	I	Ttt/Att	-8.66	0	0	benign	0.01	neutral	0.47	neutral	2.06	neutral	1.14	neutral	1.04	neutral_impact	-1.58	0.91	neutral	0.97	neutral	2.97	22.10	deleterious	0.15	0.45	0.74	disease	0.12	neutral	0.4	neutral	0.4	neutral	2	0.52	neutral	0.73	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.18	medium_impact	-2.47	low_impact	0.46	0.8	NA	NA	0.39	N	0.16	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5494	5494	T	G	MI.14917	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1025	342	F	C	tTt/tGt	-0.57	0	0	benign	0.19	neutral	0.08	neutral	1.96	neutral	-2.13	neutral	-0.45	neutral_impact	0	0.86	neutral	0.5	neutral	4.33	24.00	deleterious	0.1	0.4	0.9	disease	0.28	neutral	0.64	disease	0.61	disease	2	0.91	neutral	0.45	neutral	-6	neutral	0.51	deleterious	-0.22	medium_impact	-0.38	medium_impact	-1.14	low_impact	0.28	0.8	NA	NA	0.39	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5494	5494	T	A	MI.14918	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1025	342	F	Y	tTt/tAt	-0.57	0	0	benign	0.02	neutral	0.47	neutral	1.98	neutral	-0.6	neutral	-0.53	neutral_impact	0	0.9	neutral	0.61	neutral	2.92	21.90	deleterious	0.11	0.4	0.58	disease	0.12	neutral	0.52	disease	0.35	neutral	3	0.5	neutral	0.73	deleterious	-6	neutral	0.23	neutral	0.75	medium_impact	0.18	medium_impact	-1.14	low_impact	0.37	0.8	NA	NA	0.44	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5494	5494	T	C	MI.14919	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1025	342	F	S	tTt/tCt	-0.57	0	0	benign	0.02	neutral	0.36	neutral	2.07	neutral	1.26	neutral	-0.52	neutral_impact	-0.9	0.83	neutral	0.68	neutral	4.21	23.90	deleterious	0.07	0.35	0.49	neutral	0.16	neutral	0.53	disease	0.27	neutral	5	0.62	neutral	0.67	deleterious	-6	neutral	0.27	neutral	0.75	medium_impact	0.07	medium_impact	-1.9	low_impact	0.25	0.8	NA	NA	0.34	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8388	8388	T	G	MI.1492	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	23	8	V	G	gTa/gGa	1.52	0.18	0	probably_damaging	0.99	neutral	0.33	neutral	1.96	neutral	-1.44	deleterious	-2.56	low_impact	1.1	0.99	neutral	0.46	neutral	3.58	23.20	deleterious	0.33137158	0.85	0.53	disease	0.28	neutral	0.52	disease	0.17	neutral	7	0.99	deleterious	0.17	neutral	-2	neutral	0.72	deleterious	-2.65	low_impact	0.12	medium_impact	-0.16	medium_impact	0.38	0.85	2.94	7.06	0.48	N	0.44	polymorphism	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5495	5495	T	G	MI.14920	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1026	342	F	L	ttT/ttG	-0.34	0	0.01	benign	0	neutral	1	neutral	2.37	neutral	3.25	neutral	1.46	neutral_impact	-2.2	0.98	neutral	0.98	neutral	1.27	12.12	neutral	0.18	0.45	0.57	disease	0.07	neutral	0.34	neutral	0.28	neutral	4	0	neutral	1	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	1.87	high_impact	-3	low_impact	0.55	0.8	NA	NA	0.35	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5495	5495	T	A	MI.14921	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1026	342	F	L	ttT/ttA	-0.34	0	0.01	benign	0	neutral	1	neutral	2.37	neutral	3.25	neutral	1.46	neutral_impact	-2.2	0.98	neutral	0.98	neutral	1.40	12.79	neutral	0.18	0.45	0.57	disease	0.07	neutral	0.34	neutral	0.28	neutral	4	0	neutral	1	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	1.87	high_impact	-3	low_impact	0.55	0.8	NA	NA	0.35	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5496	5496	A	C	MI.14922	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1027	343	M	L	Ata/Cta	-0.57	0	0	benign	0.32	neutral	1	neutral	2.31	neutral	2.12	neutral	-0.79	neutral_impact	-1.24	0.89	neutral	0.99	neutral	-0.98	0.02	neutral	0.16	0.45	0.29	neutral	0.1	neutral	0.42	neutral	0.24	neutral	5	0.32	neutral	0.84	deleterious	-6	neutral	0.21	neutral	-0.5	medium_impact	1.87	high_impact	-2.19	low_impact	0.25	0.8	6.63	8	0.39	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5496	5496	A	G	MI.14923	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1027	343	M	V	Ata/Gta	-0.57	0	0	possibly_damaging	0.52	neutral	0.41	neutral	2	neutral	-0.01	neutral	-1.97	neutral_impact	0.74	0.96	neutral	0.96	neutral	0.03	2.87	deleterious	0.16	0.45	0.27	neutral	0.19	neutral	0.52	disease	0.38	neutral	2	0.58	neutral	0.45	neutral	-3	neutral	0.27	neutral	-0.83	medium_impact	0.12	medium_impact	-0.52	medium_impact	0.20	0.8	6.63	8	0.4	N	0.08	polymorphism	1	0.03	rs879099820	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5496	5496	A	T	MI.14924	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1027	343	M	L	Ata/Tta	-0.57	0	0	benign	0.32	neutral	1	neutral	2.31	neutral	2.12	neutral	-0.79	neutral_impact	-1.24	0.89	neutral	0.99	neutral	-0.92	0.02	neutral	0.16	0.45	0.29	neutral	0.1	neutral	0.42	neutral	0.24	neutral	5	0.32	neutral	0.84	deleterious	-6	neutral	0.21	neutral	-0.5	medium_impact	1.87	high_impact	-2.19	low_impact	0.25	0.8	6.63	8	0.38	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5497	5497	T	A	MI.14925	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1028	343	M	K	aTa/aAa	-0.11	0	0	possibly_damaging	0.74	neutral	0.21	neutral	1.91	neutral	-2.85	deleterious	-3.96	low_impact	1.59	0.85	neutral	0.43	neutral	2.37	18.64	deleterious	0.1	0.4	0.54	disease	0.45	neutral	0.73	disease	0.66	disease	3	0.85	neutral	0.24	neutral	-3	neutral	0.55	deleterious	-1.21	low_impact	-0.11	medium_impact	0.19	medium_impact	0.24	0.8	6.63	8	0.34	N	0.48	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5497	5497	T	C	MI.14926	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1028	343	M	T	aTa/aCa	-0.11	0	0	possibly_damaging	0.74	neutral	0.44	neutral	1.98	neutral	-0.34	deleterious	-3.05	neutral_impact	0.74	0.95	neutral	0.75	neutral	0.21	4.83	deleterious	0.12	0.4	0.49	neutral	0.19	neutral	0.66	disease	0.4	neutral	2	0.73	neutral	0.35	neutral	-3	neutral	0.50	deleterious	-1.21	low_impact	0.15	medium_impact	-0.52	medium_impact	0.15	0.8	6.63	8	0.37	N	0.08	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5498	5498	A	C	MI.14927	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1029	343	M	I	atA/atC	2.9	0.03	0.01	possibly_damaging	0.64	neutral	0.66	neutral	2.38	neutral	2.42	neutral	-1.51	neutral_impact	-0.28	0.87	neutral	0.95	neutral	-0.12	1.60	neutral	0.12	0.4	0.24	neutral	0.05	neutral	0.41	neutral	0.18	neutral	6	0.57	neutral	0.51	deleterious	-3	neutral	0.33	neutral	-1.03	low_impact	0.37	medium_impact	-1.38	low_impact	0.24	0.8	6.63	8	0.45	N	0.05	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5498	5498	A	T	MI.14928	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1029	343	M	I	atA/atT	2.9	0.03	0.01	possibly_damaging	0.64	neutral	0.66	neutral	2.38	neutral	2.42	neutral	-1.51	neutral_impact	-0.28	0.87	neutral	0.95	neutral	-0.07	1.95	neutral	0.12	0.4	0.24	neutral	0.05	neutral	0.41	neutral	0.18	neutral	6	0.57	neutral	0.51	deleterious	-3	neutral	0.33	neutral	-1.03	low_impact	0.37	medium_impact	-1.38	low_impact	0.24	0.8	6.63	8	0.45	N	0.05	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5499	5499	C	A	MI.14929	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1030	344	L	M	Cta/Ata	-3.34	0	0	probably_damaging	0.98	neutral	0.32	neutral	1.74	neutral	-2.03	neutral	-0.59	neutral_impact	0.56	0.92	neutral	0.85	neutral	2.15	17.21	deleterious	0.15	0.45	0.47	neutral	0.06	neutral	0.39	neutral	0.25	neutral	5	0.98	deleterious	0.17	neutral	-2	neutral	0.66	deleterious	-2.34	low_impact	0.03	medium_impact	-0.67	medium_impact	0.49	0.8	6.92	10.05	0.53	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8388	8388	T	C	MI.1493	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	23	8	V	A	gTa/gCa	1.52	0.18	0	probably_damaging	0.97	neutral	0.51	neutral	2	neutral	-0.12	neutral	-0.52	neutral_impact	0.76	0.99	neutral	0.76	neutral	3.26	22.80	deleterious	0.66000491	0.85	0.29	neutral	0.11	neutral	0.5	neutral	0.14	neutral	7	0.97	neutral	0.27	neutral	-2	neutral	0.66	deleterious	-2.19	low_impact	0.3	medium_impact	-0.45	medium_impact	0.39	0.85	2.94	7.06	0.46	N	0.36	polymorphism	1	0.05	rs879199176	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	5499	5499	C	G	MI.14930	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1030	344	L	V	Cta/Gta	-3.34	0	0	possibly_damaging	0.89	neutral	0.57	neutral	1.76	neutral	-1.84	neutral	-1.13	neutral_impact	0.74	0.92	neutral	0.75	neutral	2.14	17.12	deleterious	0.22	0.45	0.42	neutral	0.14	neutral	0.45	neutral	0.29	neutral	4	0.87	neutral	0.34	neutral	-3	neutral	0.63	deleterious	-1.63	low_impact	0.28	medium_impact	-0.52	medium_impact	0.34	0.8	6.92	10.05	0.36	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5500	5500	T	C	MI.14931	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1031	344	L	P	cTa/cCa	-5.89	0	0	probably_damaging	0.99	neutral	0.23	neutral	1.68	deleterious	-3.77	deleterious	-3	low_impact	1.5	0.79	neutral	0.12	damaging	4.09	23.70	deleterious	0.08	0.35	0.82	disease	0.41	neutral	0.75	disease	0.72	disease	4	0.99	deleterious	0.12	neutral	-2	neutral	0.78	deleterious	-2.62	low_impact	-0.08	medium_impact	0.12	medium_impact	0.25	0.8	6.92	10.05	0.27	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5500	5500	T	A	MI.14932	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1031	344	L	Q	cTa/cAa	-5.89	0	0	probably_damaging	0.99	neutral	0.3	neutral	1.67	deleterious	-4.32	neutral	-2.29	low_impact	1.08	0.86	neutral	0.17	damaging	4.31	24.00	deleterious	0.11	0.4	0.74	disease	0.3	neutral	0.65	disease	0.65	disease	3	0.99	deleterious	0.16	neutral	-2	neutral	0.72	deleterious	-2.62	low_impact	0	medium_impact	-0.24	medium_impact	0.24	0.8	6.92	10.05	0.31	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5500	5500	T	G	MI.14933	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1031	344	L	R	cTa/cGa	-5.89	0	0	probably_damaging	0.98	neutral	0.34	neutral	1.66	deleterious	-4.72	deleterious	-2.67	medium_impact	2.06	0.79	neutral	0.1	damaging	4.27	24.00	deleterious	0.07	0.35	0.74	disease	0.53	disease	0.75	disease	0.76	disease	5	0.98	deleterious	0.18	neutral	1	deleterious	0.79	deleterious	-2.34	low_impact	0.05	medium_impact	0.59	medium_impact	0.20	0.8	6.92	10.05	0.24	N	0.58	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5502	5502	A	C	MI.14934	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1033	345	M	L	Ata/Cta	-6.58	0	0	benign	0.18	neutral	1	neutral	2.09	neutral	0.89	neutral	-0.11	neutral_impact	0.62	0.94	neutral	0.99	neutral	0.16	4.22	deleterious	0.13	0.4	0.4	neutral	0.07	neutral	0.35	neutral	0.26	neutral	5	0.18	neutral	0.91	deleterious	-6	neutral	0.22	neutral	-0.19	medium_impact	1.87	high_impact	-0.62	medium_impact	0.23	0.8	11.24	8.11	0.35	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5502	5502	A	T	MI.14935	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1033	345	M	L	Ata/Tta	-6.58	0	0	benign	0.18	neutral	1	neutral	2.09	neutral	0.89	neutral	-0.11	neutral_impact	0.62	0.94	neutral	0.99	neutral	0.26	5.30	deleterious	0.13	0.4	0.4	neutral	0.07	neutral	0.35	neutral	0.26	neutral	5	0.18	neutral	0.91	deleterious	-6	neutral	0.22	neutral	-0.19	medium_impact	1.87	high_impact	-0.62	medium_impact	0.23	0.8	11.24	8.11	0.35	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5502	5502	A	G	MI.14936	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1033	345	M	V	Ata/Gta	-6.58	0	0	benign	0.26	neutral	0.55	neutral	1.98	neutral	-0.31	neutral	-0.23	low_impact	0.98	0.96	neutral	0.97	neutral	-0.02	2.39	deleterious	0.13	0.4	0.42	neutral	0.11	neutral	0.38	neutral	0.26	neutral	5	0.34	neutral	0.65	deleterious	-6	neutral	0.28	neutral	-0.38	medium_impact	0.26	medium_impact	-0.32	medium_impact	0.18	0.8	11.24	8.11	0.36	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5503	5503	T	A	MI.14937	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1034	345	M	K	aTa/aAa	-1.72	0	0	possibly_damaging	0.45	neutral	0.46	neutral	1.91	neutral	-2.33	neutral	-1.28	low_impact	0.98	0.9	neutral	0.44	neutral	2.47	19.27	deleterious	0.09	0.35	0.56	disease	0.28	neutral	0.63	disease	0.53	disease	1	0.5	neutral	0.51	deleterious	-3	neutral	0.51	deleterious	-0.72	medium_impact	0.17	medium_impact	-0.32	medium_impact	0.24	0.8	11.24	8.11	0.37	N	0.47	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5503	5503	T	C	MI.14938	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1034	345	M	T	aTa/aCa	-1.72	0	0	possibly_damaging	0.45	neutral	0.61	neutral	2.1	neutral	0.93	neutral	1.44	neutral_impact	0.17	0.94	neutral	0.97	neutral	-0.16	1.34	neutral	0.1	0.4	0.41	neutral	0.04	neutral	0.42	neutral	0.25	neutral	5	0.39	neutral	0.58	deleterious	-3	neutral	0.45	deleterious	-0.72	medium_impact	0.32	medium_impact	-1	low_impact	0.15	0.8	11.24	8.11	0.36	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5504	5504	A	C	MI.14939	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1035	345	M	I	atA/atC	-1.72	0	0	benign	0.34	neutral	0.7	neutral	2.02	neutral	0.28	neutral	-0.29	low_impact	0.98	0.95	neutral	0.98	neutral	-0.97	0.02	neutral	0.11	0.4	0.53	disease	0.09	neutral	0.36	neutral	0.25	neutral	5	0.25	neutral	0.68	deleterious	-6	neutral	0.37	neutral	-0.53	medium_impact	0.41	medium_impact	-0.32	medium_impact	0.24	0.8	11.24	8.11	0.37	N	0.06	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8388	8388	T	A	MI.1494	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	23	8	V	E	gTa/gAa	1.52	0.18	0	probably_damaging	0.99	neutral	0.26	neutral	1.99	neutral	-0.17	neutral	-1.58	low_impact	1.1	0.98	neutral	0.51	neutral	4.38	24.10	deleterious	0.30143898	0.85	0.53	disease	0.41	neutral	0.58	disease	0.22	neutral	6	0.99	deleterious	0.14	neutral	-2	neutral	0.76	deleterious	-2.65	low_impact	0.04	medium_impact	-0.16	medium_impact	0.51	0.85	2.94	7.06	0.48	N	0.45	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5504	5504	A	T	MI.14940	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1035	345	M	I	atA/atT	-1.72	0	0	benign	0.34	neutral	0.7	neutral	2.02	neutral	0.28	neutral	-0.29	low_impact	0.98	0.95	neutral	0.98	neutral	-0.91	0.02	neutral	0.11	0.4	0.53	disease	0.09	neutral	0.36	neutral	0.25	neutral	5	0.25	neutral	0.68	deleterious	-6	neutral	0.37	neutral	-0.53	medium_impact	0.41	medium_impact	-0.32	medium_impact	0.24	0.8	11.24	8.11	0.37	N	0.06	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5505	5505	A	G	MI.14941	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1036	346	I	V	Atc/Gtc	-9.36	0	0	benign	0	neutral	0.19	neutral	4.23	neutral	0.06	neutral	-0.42	neutral_impact	0	0.94	neutral	0.81	neutral	1.29	12.22	neutral	0.22	0.45	0.56	disease	0.04	neutral	0.35	neutral	0.22	neutral	6	0.81	neutral	0.6	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	-0.14	medium_impact	-1.14	low_impact	0.36	0.8	NA	NA	0.5	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5505	5505	A	T	MI.14942	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1036	346	I	F	Atc/Ttc	-9.36	0	0	benign	0.01	neutral	0.31	neutral	4.08	neutral	-1.28	neutral	-1.71	neutral_impact	0	0.87	neutral	0.55	neutral	2.00	16.20	deleterious	0.11	0.4	0.76	disease	0.13	neutral	0.36	neutral	0.28	neutral	4	0.68	neutral	0.65	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.02	medium_impact	-1.14	low_impact	0.44	0.8	NA	NA	0.43	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5505	5505	A	C	MI.14943	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1036	346	I	L	Atc/Ctc	-9.36	0	0	benign	0	neutral	1	neutral	4.31	neutral	0.36	neutral	0.71	neutral_impact	0	0.9	neutral	0.93	neutral	-0.64	0.10	neutral	0.17	0.45	0.54	disease	0.02	neutral	0.21	neutral	0.2	neutral	6	0	neutral	1	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	1.87	high_impact	-1.14	low_impact	0.44	0.8	NA	NA	0.4	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5506	5506	T	C	MI.14944	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1037	346	I	T	aTc/aCc	-2.42	0	0	benign	0	neutral	0.23	neutral	4.08	neutral	-1.01	neutral	-0.87	neutral_impact	0	0.87	neutral	0.56	neutral	1.71	14.49	neutral	0.14	0.4	0.64	disease	0.09	neutral	0.55	disease	0.28	neutral	4	0.77	neutral	0.62	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	-0.08	medium_impact	-1.14	low_impact	0.25	0.8	NA	NA	0.45	N	0.72	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5506	5506	T	G	MI.14945	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1037	346	I	S	aTc/aGc	-2.42	0	0	benign	0.01	neutral	0.16	neutral	4.07	neutral	-0.81	neutral	-2.29	neutral_impact	0	0.86	neutral	0.5	neutral	2.50	19.48	deleterious	0.13	0.4	0.7	disease	0.2	neutral	0.56	disease	0.41	neutral	2	0.84	neutral	0.58	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	-0.19	medium_impact	-1.14	low_impact	0.28	0.8	NA	NA	0.4	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5506	5506	T	A	MI.14946	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1037	346	I	N	aTc/aAc	-2.42	0	0	benign	0.06	neutral	0.09	neutral	4.04	neutral	-1.7	neutral	-2.19	neutral_impact	0	0.87	neutral	0.48	neutral	2.88	21.80	deleterious	0.13	0.4	0.79	disease	0.21	neutral	0.6	disease	0.45	neutral	1	0.9	neutral	0.52	deleterious	-6	neutral	0.26	neutral	0.3	medium_impact	-0.35	medium_impact	-1.14	low_impact	0.23	0.8	NA	NA	0.43	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5507	5507	C	G	MI.14947	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1038	346	I	M	atC/atG	-1.26	0	0	benign	0.03	neutral	0.23	neutral	4.08	neutral	-1.61	neutral	-0.23	neutral_impact	0	0.95	neutral	0.77	neutral	0.46	7.14	deleterious	0.17	0.45	0.42	neutral	0.04	neutral	0.26	neutral	0.21	neutral	6	0.76	neutral	0.6	deleterious	-6	neutral	0.13	neutral	0.59	medium_impact	-0.08	medium_impact	-1.14	low_impact	0.43	0.8	NA	NA	0.52	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5507	5507	C	A	MI.14948	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1038	346	I	M	atC/atA	-1.26	0	0	benign	0.03	neutral	0.23	neutral	4.08	neutral	-1.61	neutral	-0.23	neutral_impact	0	0.95	neutral	0.77	neutral	0.88	9.95	deleterious	0.17	0.45	0.42	neutral	0.04	neutral	0.26	neutral	0.21	neutral	6	0.76	neutral	0.6	deleterious	-6	neutral	0.13	neutral	0.59	medium_impact	-0.08	medium_impact	-1.14	low_impact	0.43	0.8	NA	NA	0.52	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5508	5508	T	A	MI.14949	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1039	347	L	M	Tta/Ata	-14.22	0	0	possibly_damaging	0.87	neutral	0.31	neutral	4.1	neutral	-1.83	neutral	-0.22	neutral_impact	0	0.95	neutral	0.9	neutral	1.65	14.14	neutral	0.12	0.4	NA	NA	0.04	neutral	0.18	neutral	0.11	neutral	8	0.89	neutral	0.22	neutral	-3	neutral	0.71	deleterious	-1.55	low_impact	0.02	medium_impact	-1.14	low_impact	0.50	0.8	NA	NA	0.6	P	0.30	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8390	8390	T	C	MI.1495	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	25	9	W	R	Tgg/Cgg	-3.57	0	0	probably_damaging	1	deleterious	0	deleterious	-1.63	deleterious	-12.89	deleterious	-13.96	high_impact	3.9	0.79	neutral	0.05	damaging	3.38	22.90	deleterious	0.21191278	0.85	0.89	disease	0.56	disease	0.83	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.25	high_impact	0.17	0.85	22.06	8.23	0.31	N	0.97	polymorphism	0.82	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5508	5508	T	G	MI.14950	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1039	347	L	V	Tta/Gta	-14.22	0	0	possibly_damaging	0.61	neutral	0.63	neutral	4.2	neutral	-0.35	neutral	-0.93	neutral_impact	0	0.87	neutral	0.71	neutral	0.17	4.41	deleterious	0.18	0.45	NA	NA	0.03	neutral	0.25	neutral	0.11	neutral	8	0.54	neutral	0.51	deleterious	-3	neutral	0.45	deleterious	-0.98	medium_impact	0.34	medium_impact	-1.14	low_impact	0.50	0.8	NA	NA	0.4	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5509	5509	T	G	MI.14951	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1040	347	L	W	tTa/tGa	-6.81	0	0	probably_damaging	0.96	neutral	0.18	neutral	4.06	deleterious	-3.86	neutral	-1.34	neutral_impact	0	0.81	neutral	0.44	neutral	3.83	23.40	deleterious	0.16	0.45	NA	NA	0.18	neutral	0.61	disease	0.26	neutral	5	0.97	neutral	0.11	neutral	-2	neutral	0.85	deleterious	-2.06	low_impact	-0.16	medium_impact	-1.14	low_impact	0.24	0.8	NA	NA	0.33	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5509	5509	T	C	MI.14952	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1040	347	L	S	tTa/tCa	-6.81	0	0	possibly_damaging	0.8	neutral	0.56	neutral	4.14	neutral	-0.9	neutral	0.39	neutral_impact	0	0.76	neutral	0.57	neutral	3.58	23.20	deleterious	0.19	0.45	NA	NA	0.15	neutral	0.58	disease	0.22	neutral	6	0.77	neutral	0.38	neutral	-3	neutral	0.71	deleterious	-1.35	low_impact	0.27	medium_impact	-1.14	low_impact	0.19	0.8	NA	NA	0.28	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5510	5510	A	T	MI.14953	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1041	347	L	F	ttA/ttT	-0.11	0	0	possibly_damaging	0.8	neutral	0.72	neutral	4.11	neutral	-1.52	neutral	-0.34	neutral_impact	0	0.91	neutral	0.55	neutral	1.58	13.74	neutral	0.18	0.45	NA	NA	0.11	neutral	0.58	disease	0.19	neutral	6	0.76	neutral	0.46	neutral	-3	neutral	0.68	deleterious	-1.35	low_impact	0.44	medium_impact	-1.14	low_impact	0.51	0.8	NA	NA	0.33	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5510	5510	A	C	MI.14954	MT-ND2	I	ENSG00000198763	ENSP00000355046	ENST00000361453	NU2M_HUMAN	P03891	4536	YP_003024027.1	1041	347	L	F	ttA/ttC	-0.11	0	0	possibly_damaging	0.8	neutral	0.72	neutral	4.11	neutral	-1.52	neutral	-0.34	neutral_impact	0	0.91	neutral	0.55	neutral	1.48	13.18	neutral	0.18	0.45	NA	NA	0.11	neutral	0.58	disease	0.19	neutral	6	0.76	neutral	0.46	neutral	-3	neutral	0.68	deleterious	-1.35	low_impact	0.44	medium_impact	-1.14	low_impact	0.51	0.8	NA	NA	0.33	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10059	10059	A	C	MI.14955	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	1	1	M	L	Ata/Cta	8.69	1	0	benign	0.32	deleterious	0	neutral	2.12	neutral	1.28	neutral	-2.34	NA	NA	0.68	neutral	0.56	neutral	1.05	10.93	neutral	0.05	0.35	NA	NA	0.36	neutral	0.28	neutral	0.2	neutral	6	1	deleterious	0.34	neutral	0	NA	0.39	neutral	NA	NA	NA	NA	NA	NA	0.50	0.8	1.74	8.66	0.65	P	0.44	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10059	10059	A	T	MI.14956	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	1	1	M	L	Ata/Tta	8.69	1	0	benign	0.32	deleterious	0	neutral	2.12	neutral	1.28	neutral	-2.34	NA	NA	0.68	neutral	0.56	neutral	1.14	11.41	neutral	0.05	0.35	NA	NA	0.36	neutral	0.28	neutral	0.2	neutral	6	1	deleterious	0.34	neutral	0	NA	0.39	neutral	NA	NA	NA	NA	NA	NA	0.50	0.8	1.74	8.66	0.66	P	0.44	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10059	10059	A	G	MI.14957	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	1	1	M	V	Ata/Gta	8.69	1	0	possibly_damaging	0.44	deleterious	0	neutral	2.02	neutral	0.83	deleterious	-3.03	NA	NA	0.65	neutral	0.6	neutral	0.55	7.77	deleterious	0.08	0.35	NA	NA	0.38	neutral	0.31	neutral	0.21	neutral	6	1	deleterious	0.28	neutral	3	deleterious	0.45	deleterious	NA	NA	NA	NA	NA	NA	0.27	0.8	1.74	8.66	0.63	P	0.43	NA	NA	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10060	10060	T	C	MI.14958	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	2	1	M	T	aTa/aCa	8.69	1	0	possibly_damaging	0.65	deleterious	0	neutral	1.92	neutral	-0.27	deleterious	-4.85	NA	NA	0.71	neutral	0.59	neutral	0.76	9.20	deleterious	0.06	0.35	NA	NA	0.48	neutral	0.57	disease	0.47	neutral	1	1	deleterious	0.18	neutral	3	deleterious	0.69	deleterious	NA	NA	NA	NA	NA	NA	0.11	0.8	1.74	8.66	0.62	P	0.62	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10060	10060	T	A	MI.14959	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	2	1	M	K	aTa/aAa	8.69	1	0	possibly_damaging	0.65	deleterious	0	neutral	1.92	neutral	-0.19	deleterious	-5.05	NA	NA	0.71	neutral	0.53	neutral	1.84	15.24	deleterious	0.05	0.35	NA	NA	0.61	disease	0.52	disease	0.56	disease	1	1	deleterious	0.18	neutral	3	deleterious	0.69	deleterious	NA	NA	NA	NA	NA	NA	0.21	0.8	1.74	8.66	0.61	P	0.92	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8390	8390	T	G	MI.1496	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	25	9	W	G	Tgg/Ggg	-3.57	0	0	probably_damaging	0.98	neutral	0.05	deleterious	-1.55	deleterious	-7.71	deleterious	-12.96	high_impact	3.9	0.84	neutral	0.09	damaging	3.64	23.20	deleterious	0.16637319	0.85	0.85	disease	0.42	neutral	0.78	disease	0.41	neutral	2	1	deleterious	0.04	neutral	2	deleterious	0.85	deleterious	-2.36	low_impact	-0.43	medium_impact	2.25	high_impact	0.20	0.85	22.06	8.23	0.45	N	0.93	polymorphism	0.62	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10061	10061	A	T	MI.14960	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	3	1	M	I	atA/atT	7.53	1	0	possibly_damaging	0.53	deleterious	0	neutral	2.01	neutral	0.69	deleterious	-2.93	NA	NA	0.83	neutral	0.86	neutral	0.02	2.81	deleterious	0.07	0.35	NA	NA	0.38	neutral	0.25	neutral	0.2	neutral	6	1	deleterious	0.24	neutral	3	deleterious	0.56	deleterious	NA	NA	NA	NA	NA	NA	0.55	0.8	1.74	8.66	0.59	P	0.03	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10061	10061	A	C	MI.14961	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	3	1	M	I	atA/atC	7.53	1	0	possibly_damaging	0.53	deleterious	0	neutral	2.01	neutral	0.69	deleterious	-2.93	NA	NA	0.83	neutral	0.86	neutral	-0.05	2.09	deleterious	0.07	0.35	NA	NA	0.38	neutral	0.25	neutral	0.2	neutral	6	1	deleterious	0.24	neutral	3	deleterious	0.56	deleterious	NA	NA	NA	NA	NA	NA	0.55	0.8	1.74	8.66	0.59	P	0.03	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10062	10062	A	G	MI.14962	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	4	2	N	D	Aac/Gac	-3.11	0	0	possibly_damaging	0.9	neutral	0.2	neutral	1.93	neutral	-0.42	deleterious	-4.29	medium_impact	3.38	0.69	neutral	0.22	damaging	3.50	23.10	deleterious	0.43	0.55	NA	NA	0.42	neutral	0.38	neutral	0.19	neutral	6	0.94	neutral	0.15	neutral	0	NA	0.72	deleterious	-1.58	low_impact	-0.14	medium_impact	1.99	medium_impact	0.40	0.8	6.96	8.08	0.49	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10062	10062	A	C	MI.14963	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	4	2	N	H	Aac/Cac	-3.11	0	0	probably_damaging	0.98	neutral	0.54	neutral	1.86	neutral	-1.77	deleterious	-4.26	medium_impact	3.38	0.7	neutral	0.2	damaging	2.77	21.20	deleterious	0.3	0.45	NA	NA	0.48	neutral	0.34	neutral	0.33	neutral	3	0.98	deleterious	0.28	neutral	1	deleterious	0.77	deleterious	-2.24	low_impact	0.23	medium_impact	1.99	medium_impact	0.24	0.8	6.96	8.08	0.29	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10062	10062	A	T	MI.14964	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	4	2	N	Y	Aac/Tac	-3.11	0	0	probably_damaging	0.98	neutral	1	neutral	1.86	neutral	-1.42	deleterious	-6.55	medium_impact	2.83	0.71	neutral	0.2	damaging	3.37	22.90	deleterious	0.16	0.45	NA	NA	0.59	disease	0.49	neutral	0.49	neutral	0	0.98	deleterious	0.51	deleterious	1	deleterious	0.79	deleterious	-2.24	low_impact	1.85	high_impact	1.49	medium_impact	0.38	0.8	6.96	8.08	0.21	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10063	10063	A	T	MI.14965	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	5	2	N	I	aAc/aTc	8.69	1	0	probably_damaging	0.98	neutral	0.4	neutral	1.87	neutral	-0.8	deleterious	-7.04	medium_impact	3.04	0.72	neutral	0.21	damaging	3.46	23.00	deleterious	0.17	0.45	NA	NA	0.7	disease	0.21	neutral	0.48	neutral	0	0.98	deleterious	0.21	neutral	1	deleterious	0.80	deleterious	-2.24	low_impact	0.09	medium_impact	1.68	medium_impact	0.37	0.8	6.96	8.08	0.57	P	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10063	10063	A	G	MI.14966	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	5	2	N	S	aAc/aGc	8.69	1	0	possibly_damaging	0.9	neutral	0.4	neutral	1.94	neutral	0.07	deleterious	-4.17	medium_impact	2.02	0.77	neutral	0.37	neutral	2.59	20.10	deleterious	0.44	0.55	NA	NA	0.35	neutral	0.17	neutral	0.19	neutral	6	0.9	neutral	0.25	neutral	0	NA	0.72	deleterious	-1.58	low_impact	0.09	medium_impact	0.74	medium_impact	0.37	0.8	6.96	8.08	0.57	P	0.81	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10063	10063	A	C	MI.14967	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	5	2	N	T	aAc/aCc	8.69	1	0	probably_damaging	0.94	neutral	0.39	neutral	1.91	neutral	-0.31	deleterious	-4.79	medium_impact	2.48	0.84	neutral	0.34	neutral	2.92	21.90	deleterious	0.28	0.45	NA	NA	0.41	neutral	0.15	neutral	0.2	neutral	6	0.94	neutral	0.23	neutral	1	deleterious	0.74	deleterious	-1.8	low_impact	0.08	medium_impact	1.17	medium_impact	0.31	0.8	6.96	8.08	0.54	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10064	10064	C	G	MI.14968	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	6	2	N	K	aaC/aaG	6.38	1	0	probably_damaging	0.94	neutral	0.29	neutral	1.95	neutral	-0.13	deleterious	-5.08	medium_impact	2.83	0.65	neutral	0.21	damaging	3.71	23.30	deleterious	0.42	0.5	NA	NA	0.58	disease	0.4	neutral	0.46	neutral	1	0.95	neutral	0.18	neutral	1	deleterious	0.78	deleterious	-1.8	low_impact	-0.03	medium_impact	1.49	medium_impact	0.46	0.8	6.96	8.08	0.6	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10064	10064	C	A	MI.14969	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	6	2	N	K	aaC/aaA	6.38	1	0	probably_damaging	0.94	neutral	0.29	neutral	1.95	neutral	-0.13	deleterious	-5.08	medium_impact	2.83	0.65	neutral	0.21	damaging	4.12	23.80	deleterious	0.42	0.5	NA	NA	0.58	disease	0.4	neutral	0.46	neutral	1	0.95	neutral	0.18	neutral	1	deleterious	0.78	deleterious	-1.8	low_impact	-0.03	medium_impact	1.49	medium_impact	0.46	0.8	6.96	8.08	0.6	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8391	8391	G	C	MI.1497	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	26	9	W	S	tGg/tCg	7.53	1	0	probably_damaging	0.99	deleterious	0.02	deleterious	-1.63	deleterious	-12.18	deleterious	-13.95	high_impact	3.9	0.86	neutral	0.07	damaging	3.83	23.40	deleterious	0.15456258	0.85	0.88	disease	0.54	disease	0.78	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-0.66	medium_impact	2.25	high_impact	0.16	0.85	22.06	8.23	0.58	P	0.95	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10065	10065	T	G	MI.14970	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	7	3	F	V	Ttc/Gtc	-1.26	0	0	possibly_damaging	0.9	neutral	0.33	neutral	1.98	neutral	-0.93	neutral	0.92	neutral_impact	0.06	0.91	neutral	0.92	neutral	3.84	23.40	deleterious	0.14	0.4	NA	NA	0.24	neutral	0.3	neutral	0.19	neutral	6	0.91	neutral	0.22	neutral	-3	neutral	0.62	deleterious	-1.58	low_impact	0.02	medium_impact	-1.05	low_impact	0.28	0.8	5.22	8.44	0.5	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10065	10065	T	C	MI.14971	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	7	3	F	L	Ttc/Ctc	-1.26	0	0	possibly_damaging	0.85	neutral	1	neutral	2.13	neutral	-0.14	neutral	2.44	neutral_impact	-1.7	0.96	neutral	1	neutral	1.17	11.57	neutral	0.21	0.45	NA	NA	0.05	neutral	0.18	neutral	0.16	neutral	7	0.85	neutral	0.58	deleterious	-3	neutral	0.58	deleterious	-1.4	low_impact	1.85	high_impact	-2.67	low_impact	0.50	0.8	5.22	8.44	0.29	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10065	10065	T	A	MI.14972	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	7	3	F	I	Ttc/Atc	-1.26	0	0	possibly_damaging	0.9	neutral	0.39	neutral	1.98	neutral	-0.99	neutral	1.46	neutral_impact	0.06	0.95	neutral	0.98	neutral	3.14	22.60	deleterious	0.17	0.45	NA	NA	0.17	neutral	0.2	neutral	0.22	neutral	6	0.9	neutral	0.25	neutral	-3	neutral	0.62	deleterious	-1.58	low_impact	0.08	medium_impact	-1.05	low_impact	0.58	0.8	5.22	8.44	0.46	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10066	10066	T	G	MI.14973	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	8	3	F	C	tTc/tGc	-1.49	0	0	probably_damaging	0.98	neutral	0.08	neutral	1.85	deleterious	-3.77	neutral	-0.97	low_impact	1.04	0.79	neutral	0.59	neutral	3.90	23.50	deleterious	0.08	0.35	NA	NA	0.34	neutral	0.52	disease	0.25	neutral	5	0.99	deleterious	0.05	neutral	-2	neutral	0.67	deleterious	-2.24	low_impact	-0.4	medium_impact	-0.16	medium_impact	0.15	0.8	5.22	8.44	0.39	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10066	10066	T	A	MI.14974	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	8	3	F	Y	tTc/tAc	-1.49	0	0	possibly_damaging	0.85	neutral	0.59	neutral	1.9	neutral	-0.85	neutral	-0.85	low_impact	1.04	0.81	neutral	0.68	neutral	4.03	23.60	deleterious	0.18	0.45	NA	NA	0.17	neutral	0.51	disease	0.23	neutral	5	0.82	neutral	0.37	neutral	-3	neutral	0.62	deleterious	-1.4	low_impact	0.28	medium_impact	-0.16	medium_impact	0.51	0.8	5.22	8.44	0.35	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10066	10066	T	C	MI.14975	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	8	3	F	S	tTc/tCc	-1.49	0	0	probably_damaging	0.94	neutral	0.45	neutral	1.9	neutral	-1.91	neutral	-1.35	neutral_impact	-0.12	0.83	neutral	0.79	neutral	4.01	23.60	deleterious	0.06	0.35	NA	NA	0.23	neutral	0.5	neutral	0.17	neutral	7	0.94	neutral	0.26	neutral	-2	neutral	0.66	deleterious	-1.8	low_impact	0.14	medium_impact	-1.22	low_impact	0.20	0.8	5.22	8.44	0.32	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10067	10067	C	G	MI.14976	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	9	3	F	L	ttC/ttG	2.44	0.05	0	possibly_damaging	0.85	neutral	1	neutral	2.13	neutral	-0.14	neutral	2.44	neutral_impact	-1.7	0.96	neutral	1	neutral	1.38	12.70	neutral	0.21	0.45	NA	NA	0.05	neutral	0.18	neutral	0.16	neutral	7	0.85	neutral	0.58	deleterious	-3	neutral	0.58	deleterious	-1.4	low_impact	1.85	high_impact	-2.67	low_impact	0.50	0.8	5.22	8.44	0.32	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10067	10067	C	A	MI.14977	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	9	3	F	L	ttC/ttA	2.44	0.05	0	possibly_damaging	0.85	neutral	1	neutral	2.13	neutral	-0.14	neutral	2.44	neutral_impact	-1.7	0.96	neutral	1	neutral	1.71	14.47	neutral	0.21	0.45	NA	NA	0.05	neutral	0.18	neutral	0.16	neutral	7	0.85	neutral	0.58	deleterious	-3	neutral	0.58	deleterious	-1.4	low_impact	1.85	high_impact	-2.67	low_impact	0.50	0.8	5.22	8.44	0.32	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10068	10068	G	A	MI.14978	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	10	4	A	T	Gcc/Acc	-2.65	0	0	benign	0	neutral	0.26	neutral	1.97	neutral	-0.46	neutral	0.09	neutral_impact	0.24	0.97	neutral	0.95	neutral	0.65	8.51	deleterious	0.25	0.45	NA	NA	0.07	neutral	0.25	neutral	0.19	neutral	6	0.74	neutral	0.63	deleterious	-6	neutral	0.07	neutral	1.99	medium_impact	-0.06	medium_impact	-0.89	medium_impact	0.71	0.85	14.78	10.28	0.55	P	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10068	10068	G	C	MI.14979	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	10	4	A	P	Gcc/Ccc	-2.65	0	0	benign	0.02	neutral	0.11	neutral	1.88	neutral	-2.18	neutral	-1.32	low_impact	1.18	0.93	neutral	0.83	neutral	0.60	8.18	deleterious	0.06	0.35	NA	NA	0.45	neutral	0.46	neutral	0.19	neutral	6	0.89	neutral	0.55	deleterious	-6	neutral	0.19	neutral	0.81	medium_impact	-0.31	medium_impact	-0.03	medium_impact	0.44	0.8	14.78	10.28	0.45	N	0.25	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8391	8391	G	T	MI.1498	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	26	9	W	L	tGg/tTg	7.53	1	0	probably_damaging	0.98	neutral	0.09	deleterious	-1.63	deleterious	-12.59	deleterious	-12.95	high_impact	3.56	0.86	neutral	0.06	damaging	4.03	23.60	deleterious	0.17443806	0.85	0.79	disease	0.42	neutral	0.77	disease	0.41	neutral	2	0.99	deleterious	0.06	neutral	2	deleterious	0.83	deleterious	-2.36	low_impact	-0.28	medium_impact	1.95	medium_impact	0.17	0.85	22.06	8.23	0.58	P	0.96	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10068	10068	G	T	MI.14980	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	10	4	A	S	Gcc/Tcc	-2.65	0	0	benign	0	neutral	0.15	neutral	1.94	neutral	-0.57	neutral	-0.69	neutral_impact	0.62	0.89	neutral	0.82	neutral	0.06	3.23	deleterious	0.32	0.5	NA	NA	0.08	neutral	0.28	neutral	0.21	neutral	6	0.85	neutral	0.58	deleterious	-6	neutral	0.10	neutral	1.99	medium_impact	-0.23	medium_impact	-0.54	medium_impact	0.30	0.8	14.78	10.28	0.57	P	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10069	10069	C	T	MI.14981	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	11	4	A	V	gCc/gTc	-3.11	0	0	benign	0	neutral	0.29	neutral	2.02	neutral	-0.1	neutral	1.5	neutral_impact	0.66	0.99	neutral	0.97	neutral	0.43	6.91	deleterious	0.18	0.45	NA	NA	0.1	neutral	0.29	neutral	0.2	neutral	6	0.71	neutral	0.65	deleterious	-6	neutral	0.07	neutral	1.99	medium_impact	-0.03	medium_impact	-0.5	medium_impact	0.75	0.85	14.78	10.28	0.47	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10069	10069	C	A	MI.14982	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	11	4	A	D	gCc/gAc	-3.11	0	0	benign	0.02	neutral	0.07	neutral	1.89	neutral	-1.74	neutral	-2.3	medium_impact	1.98	0.84	neutral	0.61	neutral	2.58	19.95	deleterious	0.05	0.35	NA	NA	0.38	neutral	0.66	disease	0.31	neutral	4	0.93	neutral	0.53	deleterious	-3	neutral	0.16	neutral	0.81	medium_impact	-0.43	medium_impact	0.71	medium_impact	0.23	0.8	14.78	10.28	0.4	N	0.37	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10069	10069	C	G	MI.14983	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	11	4	A	G	gCc/gGc	-3.11	0	0	benign	0	neutral	0.08	neutral	1.9	neutral	-1.51	neutral	-2.42	low_impact	1.63	0.87	neutral	0.73	neutral	0.96	10.43	neutral	0.3	0.45	NA	NA	0.14	neutral	0.5	neutral	0.25	neutral	5	0.92	neutral	0.54	deleterious	-6	neutral	0.09	neutral	1.99	medium_impact	-0.4	medium_impact	0.39	medium_impact	0.51	0.8	14.78	10.28	0.5	N	0.31	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10071	10071	T	G	MI.14984	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	13	5	L	V	Tta/Gta	-3.8	0	0	possibly_damaging	0.9	neutral	0.52	neutral	1.89	neutral	-0.66	neutral	-1.05	low_impact	1.78	0.92	neutral	0.94	neutral	2.07	16.63	deleterious	0.27	0.45	NA	NA	0.19	neutral	0.32	neutral	0.22	neutral	6	0.89	neutral	0.31	neutral	-3	neutral	0.65	deleterious	-1.58	low_impact	0.21	medium_impact	0.52	medium_impact	0.64	0.8	4.35	7.91	0.4	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10071	10071	T	A	MI.14985	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	13	5	L	M	Tta/Ata	-3.8	0	0	probably_damaging	0.98	neutral	0.39	neutral	1.8	neutral	-2.14	neutral	-0.92	low_impact	1.26	0.93	neutral	0.97	neutral	2.09	16.77	deleterious	0.24	0.45	NA	NA	0.09	neutral	0.3	neutral	0.26	neutral	5	0.98	deleterious	0.21	neutral	-2	neutral	0.65	deleterious	-2.24	low_impact	0.08	medium_impact	0.05	medium_impact	0.61	0.8	4.35	7.91	0.5	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10072	10072	T	C	MI.14986	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	14	5	L	S	tTa/tCa	-6.35	0	0	probably_damaging	0.96	neutral	0.25	neutral	1.78	neutral	-2.81	deleterious	-3.69	medium_impact	1.98	0.76	neutral	0.43	neutral	3.59	23.20	deleterious	0.05	0.35	NA	NA	0.34	neutral	0.41	neutral	0.17	neutral	7	0.97	neutral	0.15	neutral	1	deleterious	0.72	deleterious	-1.96	low_impact	-0.08	medium_impact	0.71	medium_impact	0.33	0.8	4.35	7.91	0.36	N	0.65	polymorphism	1	0.10	.	.	.	.	.	.	COSM1331643	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10072	10072	T	G	MI.14987	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	14	5	L	W	tTa/tGa	-6.35	0	0	probably_damaging	0.99	neutral	0.11	neutral	1.72	deleterious	-5.23	deleterious	-4.48	medium_impact	3.33	0.74	neutral	0.16	damaging	3.64	23.20	deleterious	0.06	0.35	NA	NA	0.48	neutral	0.64	disease	0.52	disease	0	0.99	deleterious	0.06	neutral	1	deleterious	0.73	deleterious	-2.52	low_impact	-0.31	medium_impact	1.94	medium_impact	0.27	0.8	4.35	7.91	0.35	N	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10073	10073	A	T	MI.14988	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	15	5	L	F	ttA/ttT	-0.1	0	0	probably_damaging	0.96	neutral	0.68	neutral	1.79	neutral	-2.29	deleterious	-2.62	low_impact	1.54	0.89	neutral	0.6	neutral	2.42	18.93	deleterious	0.21	0.45	NA	NA	0.32	neutral	0.36	neutral	0.18	neutral	6	0.96	neutral	0.36	neutral	-2	neutral	0.69	deleterious	-1.96	low_impact	0.37	medium_impact	0.3	medium_impact	0.71	0.85	4.35	7.91	0.3	N	0.35	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10073	10073	A	C	MI.14989	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	15	5	L	F	ttA/ttC	-0.1	0	0	probably_damaging	0.96	neutral	0.68	neutral	1.79	neutral	-2.29	deleterious	-2.62	low_impact	1.54	0.89	neutral	0.6	neutral	2.27	17.99	deleterious	0.21	0.45	NA	NA	0.32	neutral	0.36	neutral	0.18	neutral	6	0.96	neutral	0.36	neutral	-2	neutral	0.69	deleterious	-1.96	low_impact	0.37	medium_impact	0.3	medium_impact	0.71	0.85	4.35	7.91	0.3	N	0.35	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8392	8392	G	C	MI.1499	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	27	9	W	C	tgG/tgC	9.15	1	0.01	probably_damaging	1	deleterious	0	deleterious	-1.63	deleterious	-13.64	deleterious	-12.96	high_impact	3.9	0.84	neutral	0.05	damaging	3.76	23.30	deleterious	0.21080113	0.85	0.94	disease	0.5	neutral	0.8	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.25	high_impact	0.17	0.85	22.06	8.23	0.56	P	0.92	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10074	10074	A	C	MI.14990	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	16	6	I	L	Att/Ctt	-6.12	0	0	benign	0	neutral	0.93	neutral	2.02	neutral	0.32	neutral	-0.23	neutral_impact	0.64	0.82	neutral	0.71	neutral	0.57	7.98	deleterious	0.2	0.45	0.15	neutral	0.28	neutral	0.29	neutral	0.44	neutral	1	0.06	neutral	0.97	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	0.81	medium_impact	-0.52	medium_impact	0.39	0.8	11.3	8.73	0.28	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10074	10074	A	T	MI.14991	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	16	6	I	F	Att/Ttt	-6.12	0	0	benign	0.04	neutral	0.63	neutral	1.95	neutral	-0.26	neutral	-1.21	neutral_impact	-0.04	0.82	neutral	0.8	neutral	0.61	8.24	deleterious	0.16	0.45	0.3	neutral	0.34	neutral	0.37	neutral	0.45	neutral	1	0.32	neutral	0.8	deleterious	-6	neutral	0.18	neutral	0.53	medium_impact	0.32	medium_impact	-1.15	low_impact	0.46	0.8	11.3	8.73	0.28	N	0.31	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10074	10074	A	G	MI.14992	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	16	6	I	V	Att/Gtt	-6.12	0	0	benign	0	neutral	0.34	neutral	1.99	neutral	-0.1	neutral	0.4	low_impact	1.01	0.93	neutral	0.96	neutral	-1.24	0.01	neutral	0.27	0.45	0.15	neutral	0.08	neutral	0.33	neutral	0.28	neutral	5	0.66	neutral	0.67	deleterious	-6	neutral	0.06	neutral	1.99	medium_impact	0.03	medium_impact	-0.18	medium_impact	0.30	0.8	11.3	8.73	0.44	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10075	10075	T	C	MI.14993	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	17	6	I	T	aTt/aCt	-1.03	0	0	benign	0.01	neutral	0.7	neutral	1.9	neutral	-1.29	neutral	1.83	neutral_impact	-0.38	0.95	neutral	1	neutral	-1.14	0.01	neutral	0.11	0.4	0.15	neutral	0.15	neutral	0.35	neutral	0.27	neutral	5	0.28	neutral	0.85	deleterious	-6	neutral	0.10	neutral	1.09	medium_impact	0.39	medium_impact	-1.46	low_impact	0.26	0.8	11.3	8.73	0.26	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10075	10075	T	G	MI.14994	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	17	6	I	S	aTt/aGt	-1.03	0	0	benign	0.01	neutral	0.49	neutral	1.87	neutral	-1.66	neutral	1.19	neutral_impact	0.72	0.92	neutral	0.94	neutral	0.93	10.25	neutral	0.06	0.35	0.24	neutral	0.43	neutral	0.41	neutral	0.46	neutral	1	0.5	neutral	0.74	deleterious	-6	neutral	0.12	neutral	1.09	medium_impact	0.18	medium_impact	-0.45	medium_impact	0.28	0.8	11.3	8.73	0.34	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10075	10075	T	A	MI.14995	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	17	6	I	N	aTt/aAt	-1.03	0	0	benign	0.06	neutral	0.1	neutral	1.83	neutral	-2.76	neutral	-0.5	low_impact	1.62	0.74	neutral	0.4	neutral	2.68	20.70	deleterious	0.1	0.4	0.2	neutral	0.53	disease	0.54	disease	0.69	disease	4	0.89	neutral	0.52	deleterious	-6	neutral	0.19	neutral	0.36	medium_impact	-0.34	medium_impact	0.38	medium_impact	0.29	0.8	11.3	8.73	0.42	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10076	10076	T	G	MI.14996	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	18	6	I	M	atT/atG	0.36	0	0	benign	0.1	neutral	0.6	neutral	1.89	neutral	-1.43	neutral	0.02	neutral_impact	0.19	0.89	neutral	0.91	neutral	-0.29	0.70	neutral	0.22	0.45	0.19	neutral	0.09	neutral	0.21	neutral	0.26	neutral	5	0.31	neutral	0.75	deleterious	-6	neutral	0.31	neutral	0.15	medium_impact	0.29	medium_impact	-0.93	medium_impact	0.46	0.8	11.3	8.73	0.39	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10076	10076	T	A	MI.14997	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	18	6	I	M	atT/atA	0.36	0	0	benign	0.1	neutral	0.6	neutral	1.89	neutral	-1.43	neutral	0.02	neutral_impact	0.19	0.89	neutral	0.91	neutral	0.08	3.41	deleterious	0.22	0.45	0.19	neutral	0.09	neutral	0.21	neutral	0.26	neutral	5	0.31	neutral	0.75	deleterious	-6	neutral	0.31	neutral	0.15	medium_impact	0.29	medium_impact	-0.93	medium_impact	0.46	0.8	11.3	8.73	0.38	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10077	10077	T	A	MI.14998	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	19	7	L	M	Tta/Ata	-20	0	0	probably_damaging	0.98	neutral	0.51	neutral	1.69	deleterious	-3	neutral	-1.14	low_impact	1.94	0.87	neutral	0.93	neutral	2.32	18.32	deleterious	0.27	0.45	0.4	neutral	0.14	neutral	0.39	neutral	0.32	neutral	4	0.98	deleterious	0.27	neutral	-2	neutral	0.63	deleterious	-2.24	low_impact	0.2	medium_impact	0.67	medium_impact	0.48	0.8	2.61	9.21	0.39	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10077	10077	T	G	MI.14999	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	19	7	L	V	Tta/Gta	-20	0	0	possibly_damaging	0.9	neutral	0.47	neutral	1.78	neutral	-1.23	neutral	-1.76	low_impact	1.94	0.87	neutral	0.78	neutral	2.26	17.89	deleterious	0.21	0.45	0.33	neutral	0.27	neutral	0.39	neutral	0.45	neutral	1	0.89	neutral	0.29	neutral	-3	neutral	0.62	deleterious	-1.58	low_impact	0.16	medium_impact	0.67	medium_impact	0.51	0.8	2.61	9.21	0.35	N	0.53	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8533	8533	G	C	MI.15	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	7	3	E	Q	Gaa/Caa	-0.1	0.06	0	probably_damaging	0.97	neutral	0.34	neutral	4.66	neutral	-0.83	neutral	-0.94	low_impact	1.61	0.92	neutral	0.68	neutral	1.32	12.35	neutral	0.68	0.75	0.28	neutral	0.1	neutral	0.11	neutral	0.34	neutral	3	0.97	neutral	0.19	neutral	-2	neutral	0.60	deleterious	-2.19	low_impact	0.13	medium_impact	0.28	medium_impact	0.86	0.9	15.93	14.48	0.56	P	0.89	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8596	8596	A	C	MI.150	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	70	24	I	L	Att/Ctt	-7.51	0	0	probably_damaging	0.93	neutral	1	neutral	4.06	neutral	-1.62	neutral	-0.73	neutral_impact	-0.51	0.83	neutral	0.81	neutral	1.18	11.64	neutral	0.35	0.65	0.24	neutral	0.12	neutral	0.25	neutral	0.26	neutral	5	0.93	neutral	0.54	deleterious	-2	neutral	0.58	deleterious	-1.82	low_impact	1.98	high_impact	-1.54	low_impact	0.52	0.9	18.14	17.22	0.25	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8392	8392	G	T	MI.1500	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	27	9	W	C	tgG/tgT	9.15	1	0.01	probably_damaging	1	deleterious	0	deleterious	-1.63	deleterious	-13.64	deleterious	-12.96	high_impact	3.9	0.84	neutral	0.05	damaging	3.93	23.50	deleterious	0.21080113	0.85	0.94	disease	0.5	neutral	0.8	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.25	high_impact	0.17	0.85	22.06	8.23	0.56	P	0.92	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10078	10078	T	G	MI.15000	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	20	7	L	W	tTa/tGa	-2.42	0	0	probably_damaging	0.99	neutral	0.05	neutral	1.61	deleterious	-5.8	deleterious	-4.78	high_impact	3.83	0.76	neutral	0.06	damaging	3.66	23.20	deleterious	0.05	0.35	0.84	disease	0.62	disease	0.68	disease	0.74	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.76	deleterious	-2.52	low_impact	-0.52	medium_impact	2.4	high_impact	0.20	0.8	2.61	9.21	0.34	N	0.95	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10078	10078	T	C	MI.15001	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	20	7	L	S	tTa/tCa	-2.42	0	0	probably_damaging	0.96	neutral	0.54	neutral	1.65	deleterious	-3.49	deleterious	-4.61	medium_impact	2.47	0.76	neutral	0.1	damaging	3.69	23.30	deleterious	0.04	0.35	0.71	disease	0.49	neutral	0.65	disease	0.66	disease	3	0.96	neutral	0.29	neutral	1	deleterious	0.74	deleterious	-1.96	low_impact	0.23	medium_impact	1.16	medium_impact	0.24	0.8	2.61	9.21	0.21	N	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10079	10079	A	T	MI.15002	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	21	7	L	F	ttA/ttT	3.6	0.28	0	probably_damaging	0.96	neutral	0.39	neutral	1.7	neutral	-2.69	deleterious	-2.85	low_impact	1.87	0.81	neutral	0.47	neutral	2.22	17.66	deleterious	0.16	0.45	0.27	neutral	0.37	neutral	0.43	neutral	0.46	neutral	1	0.96	neutral	0.22	neutral	-2	neutral	0.65	deleterious	-1.96	low_impact	0.08	medium_impact	0.61	medium_impact	0.53	0.8	2.61	9.21	0.38	N	0.76	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10079	10079	A	C	MI.15003	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	21	7	L	F	ttA/ttC	3.6	0.28	0	probably_damaging	0.96	neutral	0.39	neutral	1.7	neutral	-2.69	deleterious	-2.85	low_impact	1.87	0.81	neutral	0.47	neutral	2.08	16.72	deleterious	0.16	0.45	0.27	neutral	0.37	neutral	0.43	neutral	0.46	neutral	1	0.96	neutral	0.22	neutral	-2	neutral	0.65	deleterious	-1.96	low_impact	0.08	medium_impact	0.61	medium_impact	0.53	0.8	2.61	9.21	0.37	N	0.76	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10080	10080	A	T	MI.15004	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	22	8	M	L	Ata/Tta	-5.42	0	0	benign	0	neutral	1	neutral	2.11	neutral	1.59	neutral	0.2	neutral_impact	-0.3	0.89	neutral	0.99	neutral	-1.48	0.00	neutral	0.22	0.45	0.08	neutral	0.24	neutral	0.34	neutral	0.4	neutral	2	0	neutral	1	deleterious	-6	neutral	0.07	neutral	1.99	medium_impact	1.85	high_impact	-1.38	low_impact	0.28	0.8	18.26	8.78	0.35	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10080	10080	A	G	MI.15005	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	22	8	M	V	Ata/Gta	-5.42	0	0	benign	0	neutral	0.53	neutral	2.05	neutral	1.2	neutral	-0.96	low_impact	0.88	0.93	neutral	0.86	neutral	-0.69	0.08	neutral	0.25	0.45	0.11	neutral	0.3	neutral	0.39	neutral	0.43	neutral	1	0.47	neutral	0.77	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	0.22	medium_impact	-0.3	medium_impact	0.27	0.8	18.26	8.78	0.34	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10080	10080	A	C	MI.15006	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	22	8	M	L	Ata/Cta	-5.42	0	0	benign	0	neutral	1	neutral	2.11	neutral	1.59	neutral	0.2	neutral_impact	-0.3	0.89	neutral	0.99	neutral	-1.54	0.00	neutral	0.22	0.45	0.08	neutral	0.24	neutral	0.34	neutral	0.4	neutral	2	0	neutral	1	deleterious	-6	neutral	0.07	neutral	1.99	medium_impact	1.85	high_impact	-1.38	low_impact	0.28	0.8	18.26	8.78	0.35	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10081	10081	T	A	MI.15007	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	23	8	M	K	aTa/aAa	-8.89	0	0	benign	0	neutral	0.12	neutral	1.91	neutral	-0.94	deleterious	-3.17	medium_impact	2.67	0.81	neutral	0.46	neutral	1.87	15.42	deleterious	0.05	0.35	0.3	neutral	0.7	disease	0.71	disease	0.77	disease	5	0.88	neutral	0.56	deleterious	-3	neutral	0.18	neutral	1.99	medium_impact	-0.29	medium_impact	1.34	medium_impact	0.23	0.8	18.26	8.78	0.35	N	0.65	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10081	10081	T	C	MI.15008	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	23	8	M	T	aTa/aCa	-8.89	0	0	benign	0	neutral	0.43	neutral	1.97	neutral	0.07	neutral	-1.71	neutral_impact	-0.09	0.95	neutral	0.98	neutral	-1.00	0.02	neutral	0.12	0.4	0.14	neutral	0.2	neutral	0.39	neutral	0.34	neutral	3	0.57	neutral	0.72	deleterious	-6	neutral	0.10	neutral	1.99	medium_impact	0.12	medium_impact	-1.19	low_impact	0.15	0.8	18.26	8.78	0.34	N	0.01	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10082	10082	A	T	MI.15009	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	24	8	M	I	atA/atT	1.29	0	0	benign	0	neutral	0.91	neutral	2.06	neutral	1.08	neutral	-0.59	neutral_impact	0.29	0.93	neutral	0.98	neutral	-0.39	0.42	neutral	0.22	0.45	0.08	neutral	0.26	neutral	0.34	neutral	0.4	neutral	2	0.08	neutral	0.96	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	0.75	medium_impact	-0.84	medium_impact	0.20	0.8	18.26	8.78	0.34	N	0.21	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8393	8393	C	G	MI.1501	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	28	10	P	A	Ccc/Gcc	2.67	0.98	0.02	probably_damaging	0.99	neutral	0.05	neutral	2.03	neutral	0.86	neutral	-1.15	medium_impact	2.1	0.99	neutral	0.75	neutral	1.43	12.96	neutral	0.57262910	0.85	0.21	neutral	0.08	neutral	0.45	neutral	0.05	neutral	9	1	deleterious	0.03	neutral	1	deleterious	0.70	deleterious	-2.65	low_impact	-0.43	medium_impact	0.7	medium_impact	0.71	0.85	NA	NA	0.6	P	0.40	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10082	10082	A	C	MI.15010	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	24	8	M	I	atA/atC	1.29	0	0	benign	0	neutral	0.91	neutral	2.06	neutral	1.08	neutral	-0.59	neutral_impact	0.29	0.93	neutral	0.98	neutral	-0.45	0.30	neutral	0.22	0.45	0.08	neutral	0.26	neutral	0.34	neutral	0.4	neutral	2	0.08	neutral	0.96	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	0.75	medium_impact	-0.84	medium_impact	0.20	0.8	18.26	8.78	0.34	N	0.21	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10083	10083	A	C	MI.15011	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	25	9	I	L	Atc/Ctc	-14.45	0	0	benign	0	neutral	1	neutral	1.9	neutral	-0.85	neutral	-1.1	low_impact	1.44	0.72	neutral	0.73	neutral	0.59	8.09	deleterious	0.23	0.45	0.18	neutral	0.44	neutral	0.34	neutral	0.45	neutral	1	0	neutral	1	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	1.85	high_impact	0.21	medium_impact	0.38	0.8	5.22	7.3	0.33	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10083	10083	A	G	MI.15012	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	25	9	I	V	Atc/Gtc	-14.45	0	0	benign	0	neutral	0.26	neutral	1.94	neutral	-0.17	neutral	-0.18	low_impact	0.83	0.92	neutral	0.96	neutral	-0.33	0.56	neutral	0.33	0.5	0.16	neutral	0.24	neutral	0.36	neutral	0.43	neutral	1	0.74	neutral	0.63	deleterious	-6	neutral	0.06	neutral	1.99	medium_impact	-0.06	medium_impact	-0.35	medium_impact	0.26	0.8	5.22	7.3	0.42	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10083	10083	A	T	MI.15013	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	25	9	I	F	Atc/Ttc	-14.45	0	0	benign	0.02	neutral	0.55	neutral	1.77	neutral	-2.07	deleterious	-2.59	low_impact	1.44	0.68	neutral	0.67	neutral	1.57	13.70	neutral	0.18	0.45	0.47	neutral	0.63	disease	0.42	neutral	0.51	disease	0	0.42	neutral	0.77	deleterious	-6	neutral	0.16	neutral	0.81	medium_impact	0.24	medium_impact	0.21	medium_impact	0.36	0.8	5.22	7.3	0.33	N	0.48	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10084	10084	T	G	MI.15014	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	26	9	I	S	aTc/aGc	-0.1	0	0.03	benign	0.01	neutral	0.21	neutral	1.74	neutral	-2.66	deleterious	-2.78	medium_impact	2.63	0.65	neutral	0.38	neutral	2.11	16.93	deleterious	0.07	0.35	0.49	neutral	0.71	disease	0.56	disease	0.67	disease	3	0.79	neutral	0.6	deleterious	-3	neutral	0.16	neutral	1.09	medium_impact	-0.13	medium_impact	1.3	medium_impact	0.26	0.8	5.22	7.3	0.35	N	0.47	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10084	10084	T	A	MI.15015	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	26	9	I	N	aTc/aAc	-0.1	0	0.03	benign	0.01	deleterious	0.03	neutral	1.71	deleterious	-3.82	deleterious	-3.74	high_impact	3.61	0.6	damaging	0.36	neutral	2.40	18.83	deleterious	0.1	0.4	0.65	disease	0.71	disease	0.64	disease	0.69	disease	4	0.97	neutral	0.51	deleterious	2	deleterious	0.20	neutral	1.09	medium_impact	-0.65	medium_impact	2.2	high_impact	0.30	0.8	5.22	7.3	0.34	N	0.53	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10084	10084	T	C	MI.15016	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	26	9	I	T	aTc/aCc	-0.1	0	0.03	benign	0	neutral	0.35	neutral	1.78	neutral	-2.15	neutral	-0.96	low_impact	1.3	0.92	neutral	0.98	neutral	-0.28	0.72	neutral	0.15	0.4	0.18	neutral	0.34	neutral	0.4	neutral	0.44	neutral	1	0.65	neutral	0.68	deleterious	-6	neutral	0.10	neutral	1.99	medium_impact	0.04	medium_impact	0.08	medium_impact	0.31	0.8	5.22	7.3	0.37	N	0.12	polymorphism	1	0.04	rs41487950	Likely_benign	not_provided	237308	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10085	10085	C	G	MI.15017	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	27	9	I	M	atC/atG	-0.57	0	0	benign	0.05	neutral	0.37	neutral	1.75	neutral	-2.6	neutral	-1.61	low_impact	1.8	0.8	neutral	0.9	neutral	1.14	11.45	neutral	0.29	0.45	0.44	neutral	0.46	neutral	0.35	neutral	0.47	neutral	1	0.6	neutral	0.66	deleterious	-6	neutral	0.13	neutral	0.44	medium_impact	0.06	medium_impact	0.54	medium_impact	0.39	0.8	5.22	7.3	0.39	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10085	10085	C	A	MI.15018	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	27	9	I	M	atC/atA	-0.57	0	0	benign	0.05	neutral	0.37	neutral	1.75	neutral	-2.6	neutral	-1.61	low_impact	1.8	0.8	neutral	0.9	neutral	1.60	13.87	neutral	0.29	0.45	0.44	neutral	0.46	neutral	0.35	neutral	0.47	neutral	1	0.6	neutral	0.66	deleterious	-6	neutral	0.13	neutral	0.44	medium_impact	0.06	medium_impact	0.54	medium_impact	0.39	0.8	5.22	7.3	0.39	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10086	10086	A	T	MI.15019	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	28	10	N	Y	Aac/Tac	-10.98	0	0	probably_damaging	0.98	neutral	0.15	neutral	1.97	neutral	-0.47	deleterious	-6.14	medium_impact	2.34	0.84	neutral	0.39	neutral	3.44	23.00	deleterious	0.14	0.4	0.45	neutral	0.75	disease	0.5	neutral	0.62	disease	2	0.99	deleterious	0.09	neutral	1	deleterious	0.68	deleterious	-2.24	low_impact	-0.23	medium_impact	1.04	medium_impact	0.33	0.8	1.74	7.74	0.34	N	0.99	polymorphism	1	0.11	rs28358274	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8393	8393	C	A	MI.1502	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	28	10	P	T	Ccc/Acc	2.67	0.98	0.02	probably_damaging	1	neutral	0.09	neutral	2.17	neutral	2.45	neutral	-1.15	low_impact	1.76	0.97	neutral	0.84	neutral	2.27	18.00	deleterious	0.70671114	0.85	0.26	neutral	0.13	neutral	0.35	neutral	0.1	neutral	8	1	deleterious	0.05	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	-0.28	medium_impact	0.41	medium_impact	0.66	0.85	NA	NA	0.62	P	0.10	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10086	10086	A	G	MI.15020	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	28	10	N	D	Aac/Gac	-10.98	0	0	possibly_damaging	0.9	deleterious	0.02	neutral	1.97	neutral	-0.42	deleterious	-3.52	medium_impact	2.34	0.96	neutral	0.57	neutral	2.47	19.30	deleterious	0.44	0.55	0.23	neutral	0.68	disease	0.57	disease	0.69	disease	4	0.99	deleterious	0.06	neutral	4	deleterious	0.59	deleterious	-1.58	low_impact	-0.75	medium_impact	1.04	medium_impact	0.28	0.8	1.74	7.74	0.56	P	0.94	polymorphism	1	0.10	rs28358274	.	.	.	.	.	.	CPD	0.15	A10086G	Hypertensive end-stage renal disease	+	-	Reported	3	N	P	N,P	damaging
chrM	10086	10086	A	C	MI.15021	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	28	10	N	H	Aac/Cac	-10.98	0	0	probably_damaging	0.98	neutral	0.07	neutral	1.96	neutral	-0.86	deleterious	-3.9	medium_impact	3.04	0.83	neutral	0.34	neutral	2.84	21.60	deleterious	0.34	0.5	0.38	neutral	0.69	disease	0.58	disease	0.73	disease	5	0.99	deleterious	0.05	neutral	1	deleterious	0.65	deleterious	-2.24	low_impact	-0.43	medium_impact	1.68	medium_impact	0.26	0.8	1.74	7.74	0.38	N	0.98	polymorphism	1	0.10	rs28358274	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10087	10087	A	C	MI.15022	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	29	10	N	T	aAc/aCc	1.05	0.07	0	probably_damaging	0.94	neutral	0.23	neutral	2.04	neutral	0.75	deleterious	-4.13	low_impact	0.88	0.77	neutral	0.68	neutral	1.31	12.34	neutral	0.29	0.45	0.19	neutral	0.28	neutral	0.23	neutral	0.45	neutral	1	0.95	neutral	0.15	neutral	-2	neutral	0.60	deleterious	-1.8	low_impact	-0.1	medium_impact	-0.3	medium_impact	0.30	0.8	1.74	7.74	0.4	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10087	10087	A	G	MI.15023	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	29	10	N	S	aAc/aGc	1.05	0.07	0	possibly_damaging	0.9	neutral	0.37	neutral	2.1	neutral	1.01	deleterious	-3.38	low_impact	0.86	0.78	neutral	0.64	neutral	1.37	12.66	neutral	0.42	0.55	0.16	neutral	0.22	neutral	0.29	neutral	0.35	neutral	3	0.9	neutral	0.24	neutral	-3	neutral	0.58	deleterious	-1.58	low_impact	0.06	medium_impact	-0.32	medium_impact	0.27	0.8	1.74	7.74	0.37	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10087	10087	A	T	MI.15024	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	29	10	N	I	aAc/aTc	1.05	0.07	0	probably_damaging	0.98	neutral	1	neutral	2.02	neutral	0.95	deleterious	-6.66	low_impact	1.14	0.82	neutral	0.54	neutral	3.73	23.30	deleterious	0.16	0.45	0.34	neutral	0.84	disease	0.3	neutral	0.6	disease	2	0.98	deleterious	0.51	deleterious	-2	neutral	0.67	deleterious	-2.24	low_impact	1.85	high_impact	-0.06	medium_impact	0.24	0.8	1.74	7.74	0.22	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10088	10088	C	A	MI.15025	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	30	10	N	K	aaC/aaA	2.67	0.15	0	probably_damaging	0.94	deleterious	0.03	neutral	2.01	neutral	0.52	deleterious	-4.5	medium_impact	3.04	0.83	neutral	0.31	neutral	4.09	23.70	deleterious	0.37	0.5	0.17	neutral	0.82	disease	0.58	disease	0.78	disease	6	0.99	deleterious	0.05	neutral	5	deleterious	0.63	deleterious	-1.8	low_impact	-0.65	medium_impact	1.68	medium_impact	0.41	0.8	1.74	7.74	0.42	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10088	10088	C	G	MI.15026	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	30	10	N	K	aaC/aaG	2.67	0.15	0	probably_damaging	0.94	deleterious	0.03	neutral	2.01	neutral	0.52	deleterious	-4.5	medium_impact	3.04	0.83	neutral	0.31	neutral	3.64	23.20	deleterious	0.37	0.5	0.17	neutral	0.82	disease	0.58	disease	0.78	disease	6	0.99	deleterious	0.05	neutral	5	deleterious	0.63	deleterious	-1.8	low_impact	-0.65	medium_impact	1.68	medium_impact	0.41	0.8	1.74	7.74	0.42	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10089	10089	A	T	MI.15027	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	31	11	T	S	Acc/Tcc	-9.36	0	0	possibly_damaging	0.9	neutral	0.46	neutral	1.95	neutral	-0.62	neutral	-1.38	low_impact	0.95	0.75	neutral	0.96	neutral	1.14	11.45	neutral	0.4	0.5	0.28	neutral	0.25	neutral	0.29	neutral	0.45	neutral	1	0.89	neutral	0.28	neutral	-3	neutral	0.60	deleterious	-1.58	low_impact	0.15	medium_impact	-0.24	medium_impact	0.38	0.8	10.43	8.48	0.41	N	0.10	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10089	10089	A	G	MI.15028	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	31	11	T	A	Acc/Gcc	-9.36	0	0	possibly_damaging	0.9	neutral	0.41	neutral	1.98	neutral	0.11	neutral	-1.63	low_impact	1.67	0.75	neutral	0.88	neutral	1.49	13.27	neutral	0.25	0.45	0.2	neutral	0.29	neutral	0.3	neutral	0.44	neutral	1	0.9	neutral	0.26	neutral	-3	neutral	0.59	deleterious	-1.58	low_impact	0.1	medium_impact	0.42	medium_impact	0.23	0.8	10.43	8.48	0.4	N	0.20	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10089	10089	A	C	MI.15029	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	31	11	T	P	Acc/Ccc	-9.36	0	0	probably_damaging	0.96	neutral	0.07	neutral	1.88	neutral	-2.04	deleterious	-3.14	low_impact	1.59	0.67	neutral	0.08	damaging	2.06	16.61	deleterious	0.07	0.35	0.5	neutral	0.86	disease	0.6	disease	0.78	disease	6	0.99	deleterious	0.06	neutral	-2	neutral	0.74	deleterious	-1.96	low_impact	-0.43	medium_impact	0.35	medium_impact	0.28	0.8	10.43	8.48	0.24	N	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8393	8393	C	T	MI.1503	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	28	10	P	S	Ccc/Tcc	2.67	0.98	0.02	probably_damaging	1	deleterious	0.04	neutral	2.01	neutral	0.2	neutral	-1.26	low_impact	1.17	1	neutral	0.89	neutral	2.50	19.46	deleterious	0.62290357	0.85	0.18	neutral	0.09	neutral	0.32	neutral	0.04	neutral	9	1	deleterious	0.02	neutral	2	deleterious	0.67	deleterious	-3.6	low_impact	-0.49	medium_impact	-0.1	medium_impact	0.28	0.85	NA	NA	0.67	P	0.44	polymorphism	0.98	0.04	rs121434446	risk_factor	Brain_pseudoatrophy,_reversible,_valproate-induced,_susceptibility_to	24677	MedGen:CN069322	.	.	.	.	C8393T	Reversible brain pseudoatrophy	-	+	Reported	2	N	P	N,P	neutral
chrM	10090	10090	C	T	MI.15030	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	32	11	T	I	aCc/aTc	-2.88	0	0	probably_damaging	0.96	neutral	1	neutral	2	neutral	0.01	neutral	-1	neutral_impact	0.1	0.72	neutral	0.98	neutral	1.72	14.51	neutral	0.15	0.45	0.11	neutral	0.52	disease	0.29	neutral	0.43	neutral	1	0.96	neutral	0.52	deleterious	-2	neutral	0.62	deleterious	-1.96	low_impact	1.85	high_impact	-1.02	low_impact	0.41	0.8	10.43	8.48	0.3	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10090	10090	C	A	MI.15031	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	32	11	T	N	aCc/aAc	-2.88	0	0	probably_damaging	0.96	neutral	0.09	neutral	1.88	neutral	-1.91	deleterious	-2.54	medium_impact	2.74	0.75	neutral	0.13	damaging	2.33	18.34	deleterious	0.28	0.45	0.43	neutral	0.62	disease	0.46	neutral	0.5	disease	0	0.99	deleterious	0.07	neutral	1	deleterious	0.66	deleterious	-1.96	low_impact	-0.37	medium_impact	1.4	medium_impact	0.40	0.8	10.43	8.48	0.34	N	0.51	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10090	10090	C	G	MI.15032	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	32	11	T	S	aCc/aGc	-2.88	0	0	possibly_damaging	0.9	neutral	0.46	neutral	1.95	neutral	-0.62	neutral	-1.38	low_impact	0.95	0.75	neutral	0.96	neutral	1.54	13.51	neutral	0.4	0.5	0.28	neutral	0.25	neutral	0.29	neutral	0.45	neutral	1	0.89	neutral	0.28	neutral	-3	neutral	0.60	deleterious	-1.58	low_impact	0.15	medium_impact	-0.24	medium_impact	0.38	0.8	10.43	8.48	0.39	N	0.10	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10092	10092	C	G	MI.15033	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	34	12	L	V	Ctc/Gtc	-15.6	0	0	probably_damaging	0.97	neutral	0.43	neutral	1.88	neutral	-0.43	neutral	-0.39	neutral_impact	0	0.81	neutral	0.97	neutral	1.46	13.08	neutral	0.3	0.45	0.24	neutral	0.29	neutral	0.32	neutral	0.43	neutral	1	0.97	neutral	0.23	neutral	-2	neutral	0.67	deleterious	-2.08	low_impact	0.12	medium_impact	-1.11	low_impact	0.31	0.8	3.48	7.77	0.33	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10092	10092	C	T	MI.15034	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	34	12	L	F	Ctc/Ttc	-15.6	0	0	probably_damaging	0.99	neutral	0.43	neutral	1.77	neutral	-1.95	neutral	-1.55	neutral_impact	0	0.8	neutral	0.89	neutral	2.59	20.20	deleterious	0.29	0.45	0.45	neutral	0.45	neutral	0.39	neutral	0.49	neutral	0	0.99	deleterious	0.22	neutral	-2	neutral	0.73	deleterious	-2.52	low_impact	0.12	medium_impact	-1.11	low_impact	0.38	0.8	3.48	7.77	0.3	N	0.36	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10092	10092	C	A	MI.15035	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	34	12	L	I	Ctc/Atc	-15.6	0	0	probably_damaging	0.97	neutral	0.88	neutral	1.89	neutral	-0.52	neutral	-0.3	neutral_impact	0	0.8	neutral	0.99	neutral	1.73	14.57	neutral	0.27	0.45	0.26	neutral	0.22	neutral	0.22	neutral	0.41	neutral	2	0.97	neutral	0.46	neutral	-2	neutral	0.67	deleterious	-2.08	low_impact	0.67	medium_impact	-1.11	low_impact	0.43	0.8	3.48	7.77	0.31	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10093	10093	T	G	MI.15036	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	35	12	L	R	cTc/cGc	-6.81	0	0	probably_damaging	1	neutral	0.07	neutral	1.72	neutral	-2.87	neutral	-2.15	neutral_impact	0	0.71	neutral	0.4	neutral	3.96	23.60	deleterious	0.04	0.35	0.49	neutral	0.83	disease	0.71	disease	0.79	disease	6	1	deleterious	0.04	neutral	-2	neutral	0.81	deleterious	-3.43	low_impact	-0.43	medium_impact	-1.11	low_impact	0.22	0.8	3.48	7.77	0.28	N	0.76	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10093	10093	T	C	MI.15037	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	35	12	L	P	cTc/cCc	-6.81	0	0	probably_damaging	1	neutral	0.09	neutral	1.71	deleterious	-3.63	neutral	-2.44	neutral_impact	0	0.64	neutral	0.3	neutral	3.67	23.30	deleterious	0.05	0.35	0.6	disease	0.82	disease	0.7	disease	0.78	disease	6	1	deleterious	0.05	neutral	-2	neutral	0.82	deleterious	-3.43	low_impact	-0.37	medium_impact	-1.11	low_impact	0.17	0.8	3.48	7.77	0.24	N	0.94	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10093	10093	T	A	MI.15038	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	35	12	L	H	cTc/cAc	-6.81	0	0	probably_damaging	1	neutral	0.11	neutral	1.71	deleterious	-3.56	deleterious	-2.65	neutral_impact	0	0.77	neutral	0.49	neutral	3.88	23.50	deleterious	0.07	0.35	0.63	disease	0.62	disease	0.67	disease	0.73	disease	5	1	deleterious	0.06	neutral	-2	neutral	0.76	deleterious	-3.43	low_impact	-0.31	medium_impact	-1.11	low_impact	0.23	0.8	3.48	7.77	0.27	N	0.79	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10095	10095	C	A	MI.15039	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	37	13	L	M	Cta/Ata	-10.28	0	0	probably_damaging	1	neutral	0.17	neutral	0.81	neutral	-1.45	neutral	-1.74	medium_impact	2.27	0.81	neutral	0.59	neutral	3.51	23.10	deleterious	0.26	0.45	0.46	neutral	0.48	neutral	0.53	disease	0.46	neutral	1	1	deleterious	0.09	neutral	1	deleterious	0.71	deleterious	-3.43	low_impact	-0.19	medium_impact	0.97	medium_impact	0.38	0.8	1.74	7.66	0.39	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8394	8394	C	G	MI.1504	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	29	10	P	R	cCc/cGc	-0.1	0.03	0	probably_damaging	1	deleterious	0.01	neutral	1.98	neutral	-1.24	neutral	-2.17	medium_impact	2.46	1	neutral	0.45	neutral	2.26	17.89	deleterious	0.51005936	0.85	0.36	neutral	0.27	neutral	0.63	disease	0.13	neutral	7	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-3.6	low_impact	-0.84	medium_impact	1.01	medium_impact	0.66	0.85	NA	NA	0.55	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10095	10095	C	G	MI.15040	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	37	13	L	V	Cta/Gta	-10.28	0	0	probably_damaging	0.97	neutral	0.44	neutral	0.92	neutral	-0.44	deleterious	-2.59	low_impact	1.58	0.83	neutral	0.59	neutral	3.11	22.50	deleterious	0.25	0.45	0.32	neutral	0.46	neutral	0.39	neutral	0.44	neutral	1	0.97	neutral	0.24	neutral	-2	neutral	0.70	deleterious	-2.08	low_impact	0.13	medium_impact	0.34	medium_impact	0.33	0.8	1.74	7.66	0.32	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10096	10096	T	C	MI.15041	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	38	13	L	P	cTa/cCa	-2.42	0	0	probably_damaging	1	deleterious	0.02	neutral	0.71	deleterious	-4.43	deleterious	-6.25	medium_impact	2.96	0.6	damaging	0.17	damaging	3.69	23.30	deleterious	0.06	0.35	0.85	disease	0.82	disease	0.73	disease	0.79	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-3.43	low_impact	-0.75	medium_impact	1.61	medium_impact	0.26	0.8	1.74	7.66	0.25	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10096	10096	T	G	MI.15042	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	38	13	L	R	cTa/cGa	-2.42	0	0	probably_damaging	1	deleterious	0.01	neutral	0.72	deleterious	-3.87	deleterious	-5.37	medium_impact	2.96	0.63	neutral	0.2	damaging	3.96	23.60	deleterious	0.06	0.35	0.82	disease	0.88	disease	0.74	disease	0.81	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.88	deleterious	-3.43	low_impact	-0.92	medium_impact	1.61	medium_impact	0.18	0.8	1.74	7.66	0.25	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10096	10096	T	A	MI.15043	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	38	13	L	Q	cTa/cAa	-2.42	0	0	probably_damaging	1	deleterious	0.01	neutral	0.71	deleterious	-4.02	deleterious	-5.36	medium_impact	2.96	0.73	neutral	0.24	damaging	3.86	23.50	deleterious	0.08	0.35	0.81	disease	0.73	disease	0.63	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.43	low_impact	-0.92	medium_impact	1.61	medium_impact	0.22	0.8	1.74	7.66	0.25	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10098	10098	G	A	MI.15044	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	40	14	A	T	Gcc/Acc	-4.96	0	0	probably_damaging	0.99	neutral	0.11	neutral	0.95	neutral	-0.59	neutral	-0.91	low_impact	0.92	0.9	neutral	0.97	neutral	2.75	21.10	deleterious	0.23	0.45	0.2	neutral	0.37	neutral	0.33	neutral	0.43	neutral	1	1	deleterious	0.06	neutral	-2	neutral	0.66	deleterious	-2.52	low_impact	-0.31	medium_impact	-0.27	medium_impact	0.63	0.8	11.3	8.63	0.5	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10098	10098	G	C	MI.15045	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	40	14	A	P	Gcc/Ccc	-4.96	0	0	probably_damaging	1	deleterious	0	neutral	0.92	neutral	-1.39	deleterious	-2.97	low_impact	1.66	0.77	neutral	0.8	neutral	3.54	23.10	deleterious	0.09	0.35	0.55	disease	0.88	disease	0.52	disease	0.6	disease	2	1	deleterious	0	neutral	2	deleterious	0.82	deleterious	-3.43	low_impact	-1.47	low_impact	0.41	medium_impact	0.43	0.8	11.3	8.63	0.34	N	0.79	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10098	10098	G	T	MI.15046	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	40	14	A	S	Gcc/Tcc	-4.96	0	0	probably_damaging	0.99	neutral	0.21	neutral	1.01	neutral	0.09	neutral	-0.31	neutral_impact	-0.11	0.73	neutral	0.93	neutral	0.76	9.21	deleterious	0.25	0.45	0.09	neutral	0.06	neutral	0.25	neutral	0.23	neutral	5	0.99	deleterious	0.11	neutral	-2	neutral	0.62	deleterious	-2.52	low_impact	-0.13	medium_impact	-1.21	low_impact	0.40	0.8	11.3	8.63	0.47	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10099	10099	C	T	MI.15047	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	41	14	A	V	gCc/gTc	0.13	0	0	probably_damaging	0.99	neutral	0.3	neutral	1.01	neutral	0.09	neutral	-2.48	low_impact	1.19	0.79	neutral	0.76	neutral	3.16	22.60	deleterious	0.17	0.45	0.44	neutral	0.68	disease	0.38	neutral	0.54	disease	1	0.99	deleterious	0.16	neutral	-2	neutral	0.74	deleterious	-2.52	low_impact	-0.01	medium_impact	-0.02	medium_impact	0.48	0.8	11.3	8.63	0.32	N	0.48	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10099	10099	C	A	MI.15048	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	41	14	A	D	gCc/gAc	0.13	0	0	probably_damaging	1	deleterious	0	neutral	0.88	neutral	-2.83	deleterious	-3.12	medium_impact	2.47	0.72	neutral	0.32	neutral	4.44	24.20	deleterious	0.05	0.35	0.56	disease	0.86	disease	0.7	disease	0.8	disease	6	1	deleterious	0	neutral	5	deleterious	0.80	deleterious	-3.43	low_impact	-1.47	low_impact	1.16	medium_impact	0.30	0.8	11.3	8.63	0.3	N	0.89	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10099	10099	C	G	MI.15049	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	41	14	A	G	gCc/gGc	0.13	0	0	probably_damaging	0.99	deleterious	0.03	neutral	0.94	neutral	-0.94	neutral	-2.43	low_impact	1.57	0.75	neutral	0.51	neutral	3.75	23.30	deleterious	0.25	0.45	0.38	neutral	0.63	disease	0.57	disease	0.71	disease	4	1	deleterious	0.02	neutral	2	deleterious	0.70	deleterious	-2.52	low_impact	-0.65	medium_impact	0.33	medium_impact	0.50	0.8	11.3	8.63	0.36	N	0.42	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8394	8394	C	A	MI.1505	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	29	10	P	H	cCc/cAc	-0.1	0.03	0	probably_damaging	1	deleterious	0.02	neutral	1.97	neutral	-1.79	neutral	-1.42	medium_impact	2.46	0.95	neutral	0.44	neutral	3.66	23.20	deleterious	0.47886177	0.85	0.46	neutral	0.23	neutral	0.63	disease	0.14	neutral	7	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-3.6	low_impact	-0.66	medium_impact	1.01	medium_impact	0.70	0.85	NA	NA	0.49	N	0.42	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10101	10101	T	A	MI.15050	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	43	15	L	M	Tta/Ata	-6.12	0	0.03	probably_damaging	1	neutral	0.23	neutral	0.76	neutral	-2.02	neutral	-0.05	neutral_impact	0.68	0.82	neutral	0.98	neutral	2.05	16.55	deleterious	0.24	0.45	0.33	neutral	0.17	neutral	0.29	neutral	0.31	neutral	4	1	deleterious	0.12	neutral	-2	neutral	0.66	deleterious	-3.43	low_impact	-0.1	medium_impact	-0.49	medium_impact	0.38	0.8	4.35	8.63	0.46	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10101	10101	T	G	MI.15051	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	43	15	L	V	Tta/Gta	-6.12	0	0.03	probably_damaging	0.97	neutral	0.51	neutral	0.87	neutral	-0.8	neutral	-0.7	neutral_impact	0.66	0.78	neutral	0.91	neutral	1.78	14.87	neutral	0.25	0.45	0.18	neutral	0.22	neutral	0.28	neutral	0.39	neutral	2	0.97	neutral	0.27	neutral	-2	neutral	0.65	deleterious	-2.08	low_impact	0.2	medium_impact	-0.5	medium_impact	0.43	0.8	4.35	8.63	0.32	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10102	10102	T	G	MI.15052	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	44	15	L	W	tTa/tGa	-3.34	0	0	probably_damaging	1	neutral	0.18	neutral	0.69	deleterious	-4.9	deleterious	-2.64	medium_impact	2.56	0.77	neutral	0.35	neutral	3.56	23.10	deleterious	0.08	0.35	0.65	disease	0.66	disease	0.49	neutral	0.5	neutral	0	1	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-3.43	low_impact	-0.18	medium_impact	1.24	medium_impact	0.19	0.8	4.35	8.63	0.31	N	0.60	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10102	10102	T	C	MI.15053	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	44	15	L	S	tTa/tCa	-3.34	0	0	probably_damaging	0.99	neutral	0.44	neutral	0.75	neutral	-2.27	neutral	-0.31	neutral_impact	0.3	0.89	neutral	1	neutral	1.76	14.76	neutral	0.09	0.35	0.13	neutral	0.23	neutral	0.36	neutral	0.4	neutral	2	0.99	deleterious	0.23	neutral	-2	neutral	0.65	deleterious	-2.52	low_impact	0.13	medium_impact	-0.83	medium_impact	0.19	0.8	4.35	8.63	0.37	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10103	10103	A	T	MI.15054	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	45	15	L	F	ttA/ttT	-0.8	0	0	probably_damaging	0.99	neutral	0.71	neutral	0.78	neutral	-1.8	neutral	-1.38	low_impact	1.4	0.77	neutral	0.88	neutral	2.15	17.21	deleterious	0.27	0.45	0.25	neutral	0.39	neutral	0.31	neutral	0.45	neutral	1	0.99	deleterious	0.36	neutral	-2	neutral	0.68	deleterious	-2.52	low_impact	0.41	medium_impact	0.18	medium_impact	0.44	0.8	4.35	8.63	0.26	N	0.15	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10103	10103	A	C	MI.15055	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	45	15	L	F	ttA/ttC	-0.8	0	0	probably_damaging	0.99	neutral	0.71	neutral	0.78	neutral	-1.8	neutral	-1.38	low_impact	1.4	0.77	neutral	0.88	neutral	2.03	16.38	deleterious	0.27	0.45	0.25	neutral	0.39	neutral	0.31	neutral	0.45	neutral	1	0.99	deleterious	0.36	neutral	-2	neutral	0.68	deleterious	-2.52	low_impact	0.41	medium_impact	0.18	medium_impact	0.44	0.8	4.35	8.63	0.24	N	0.15	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10104	10104	C	A	MI.15056	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	46	16	L	M	Cta/Ata	-11.21	0	0.02	probably_damaging	1	neutral	0.2	neutral	0.78	neutral	-2.02	neutral	-1.14	medium_impact	2.04	0.86	neutral	0.83	neutral	2.43	19.00	deleterious	0.25	0.45	0.34	neutral	0.33	neutral	0.4	neutral	0.46	neutral	1	1	deleterious	0.1	neutral	1	deleterious	0.67	deleterious	-3.43	low_impact	-0.14	medium_impact	0.76	medium_impact	0.52	0.8	10.43	8.69	0.45	N	0.51	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10104	10104	C	G	MI.15057	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	46	16	L	V	Cta/Gta	-11.21	0	0.02	probably_damaging	0.97	neutral	0.41	neutral	0.92	neutral	-0.51	neutral	-0.85	low_impact	1.22	0.78	neutral	0.99	neutral	1.41	12.84	neutral	0.22	0.45	0.15	neutral	0.17	neutral	0.34	neutral	0.3	neutral	4	0.97	neutral	0.22	neutral	-2	neutral	0.64	deleterious	-2.08	low_impact	0.1	medium_impact	0.01	medium_impact	0.48	0.8	10.43	8.69	0.35	N	0.38	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10105	10105	T	G	MI.15058	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	47	16	L	R	cTa/cGa	-7.51	0	0	probably_damaging	1	neutral	0.16	neutral	0.73	deleterious	-3.52	deleterious	-4.77	medium_impact	3.14	0.7	neutral	0.35	neutral	3.96	23.60	deleterious	0.05	0.35	0.55	disease	0.86	disease	0.74	disease	0.82	disease	6	1	deleterious	0.08	neutral	1	deleterious	0.83	deleterious	-3.43	low_impact	-0.21	medium_impact	1.77	medium_impact	0.24	0.8	10.43	8.69	0.32	N	0.94	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10105	10105	T	C	MI.15059	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	47	16	L	P	cTa/cCa	-7.51	0	0	probably_damaging	1	neutral	0.2	neutral	0.72	deleterious	-4.14	deleterious	-5.19	medium_impact	3.14	0.6	damaging	0.24	damaging	3.75	23.30	deleterious	0.05	0.35	0.64	disease	0.84	disease	0.73	disease	0.82	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-3.43	low_impact	-0.14	medium_impact	1.77	medium_impact	0.33	0.8	10.43	8.69	0.28	N	0.94	polymorphism	1	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8394	8394	C	T	MI.1506	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	29	10	P	L	cCc/cTc	-0.1	0.03	0	probably_damaging	1	neutral	1	neutral	2.23	neutral	2.81	neutral	0.02	neutral_impact	0.21	1	neutral	0.94	neutral	1.44	13.00	neutral	0.56962521	0.85	0.16	neutral	0.16	neutral	0.35	neutral	0.08	neutral	8	1	deleterious	0.5	deleterious	-2	neutral	0.69	deleterious	-3.6	low_impact	1.98	high_impact	-0.92	medium_impact	0.76	0.85	NA	NA	0.33	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10105	10105	T	A	MI.15060	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	47	16	L	Q	cTa/cAa	-7.51	0	0	probably_damaging	1	neutral	0.09	neutral	0.72	deleterious	-3.67	deleterious	-4.65	medium_impact	3.14	0.8	neutral	0.42	neutral	4.03	23.60	deleterious	0.08	0.35	0.56	disease	0.6	disease	0.62	disease	0.72	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.74	deleterious	-3.43	low_impact	-0.37	medium_impact	1.77	medium_impact	0.23	0.8	10.43	8.69	0.35	N	0.89	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10107	10107	C	A	MI.15061	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	49	17	L	M	Cta/Ata	-7.51	0	0	probably_damaging	1	neutral	0.24	neutral	0.81	neutral	-1.74	neutral	-1.65	medium_impact	2.21	0.72	neutral	0.53	neutral	3.52	23.10	deleterious	0.23	0.45	0.49	neutral	0.4	neutral	0.37	neutral	0.38	neutral	2	1	deleterious	0.12	neutral	1	deleterious	0.71	deleterious	-3.43	low_impact	-0.09	medium_impact	0.92	medium_impact	0.40	0.8	4.35	9	0.4	N	0.66	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10107	10107	C	G	MI.15062	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	49	17	L	V	Cta/Gta	-7.51	0	0	probably_damaging	0.97	neutral	0.57	neutral	0.87	neutral	-0.91	deleterious	-2.54	medium_impact	2.33	0.71	neutral	0.61	neutral	3.20	22.70	deleterious	0.24	0.45	0.26	neutral	0.45	neutral	0.55	disease	0.42	neutral	2	0.97	neutral	0.3	neutral	1	deleterious	0.69	deleterious	-2.08	low_impact	0.26	medium_impact	1.03	medium_impact	0.43	0.8	4.35	9	0.31	N	0.19	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10108	10108	T	G	MI.15063	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	50	17	L	R	cTa/cGa	-0.8	0	0	probably_damaging	1	neutral	0.1	neutral	0.74	deleterious	-3.4	deleterious	-5.6	high_impact	3.98	0.55	damaging	0.04	damaging	3.98	23.60	deleterious	0.06	0.35	0.8	disease	0.86	disease	0.75	disease	0.82	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.88	deleterious	-3.43	low_impact	-0.34	medium_impact	2.54	high_impact	0.18	0.8	4.35	9	0.36	N	0.98	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10108	10108	T	A	MI.15064	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	50	17	L	Q	cTa/cAa	-0.8	0	0	probably_damaging	1	deleterious	0.04	neutral	0.74	deleterious	-3.26	deleterious	-5.53	high_impact	3.63	0.59	damaging	0.06	damaging	3.99	23.60	deleterious	0.09	0.35	0.81	disease	0.72	disease	0.64	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-3.43	low_impact	-0.58	medium_impact	2.22	high_impact	0.21	0.8	4.35	9	0.27	N	0.93	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10108	10108	T	C	MI.15065	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	50	17	L	P	cTa/cCa	-0.8	0	0	probably_damaging	1	deleterious	0.03	neutral	0.74	deleterious	-3.47	deleterious	-6.48	medium_impact	3.08	0.53	damaging	0.05	damaging	3.76	23.30	deleterious	0.06	0.35	0.85	disease	0.77	disease	0.74	disease	0.8	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-3.43	low_impact	-0.65	medium_impact	1.72	medium_impact	0.28	0.8	4.35	9	0.27	N	0.93	polymorphism	1	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10110	10110	A	C	MI.15066	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	52	18	M	L	Ata/Cta	-2.42	0	0	possibly_damaging	0.66	neutral	1	neutral	1.15	neutral	1.38	neutral	-0.25	neutral_impact	-0.04	0.77	neutral	0.79	neutral	1.91	15.62	deleterious	0.15	0.45	0.14	neutral	0.55	disease	0.37	neutral	0.43	neutral	1	0.66	neutral	0.67	deleterious	-3	neutral	0.40	neutral	-0.98	medium_impact	1.85	high_impact	-1.15	low_impact	0.24	0.8	16.52	10.1	0.27	N	0.40	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10110	10110	A	G	MI.15067	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	52	18	M	V	Ata/Gta	-2.42	0	0	possibly_damaging	0.75	neutral	0.25	neutral	1.08	neutral	0.86	neutral	0.89	neutral_impact	0.66	0.83	neutral	0.99	neutral	0.04	2.96	deleterious	0.23	0.45	0.09	neutral	0.32	neutral	0.35	neutral	0.42	neutral	2	0.83	neutral	0.25	neutral	-3	neutral	0.44	deleterious	-1.15	low_impact	-0.08	medium_impact	-0.5	medium_impact	0.21	0.8	16.52	10.1	0.34	N	0.07	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10110	10110	A	T	MI.15068	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	52	18	M	L	Ata/Tta	-2.42	0	0	possibly_damaging	0.66	neutral	1	neutral	1.15	neutral	1.38	neutral	-0.25	neutral_impact	-0.04	0.77	neutral	0.79	neutral	2.01	16.27	deleterious	0.15	0.45	0.14	neutral	0.55	disease	0.37	neutral	0.43	neutral	1	0.66	neutral	0.67	deleterious	-3	neutral	0.40	neutral	-0.98	medium_impact	1.85	high_impact	-1.15	low_impact	0.24	0.8	16.52	10.1	0.3	N	0.40	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10111	10111	T	C	MI.15069	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	53	18	M	T	aTa/aCa	0.36	0	0	possibly_damaging	0.88	neutral	0.06	neutral	0.96	neutral	-0.53	neutral	-2.23	low_impact	1.05	0.86	neutral	0.86	neutral	1.63	13.99	neutral	0.12	0.4	0.21	neutral	0.23	neutral	0.41	neutral	0.41	neutral	2	0.97	neutral	0.09	neutral	-3	neutral	0.60	deleterious	-1.5	low_impact	-0.47	medium_impact	-0.15	medium_impact	0.15	0.8	16.52	10.1	0.44	N	0.37	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8396	8396	A	C	MI.1507	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	31	11	T	P	Acc/Ccc	-4.73	0	0	probably_damaging	0.99	neutral	0.22	neutral	1.78	deleterious	-4.4	deleterious	-3.41	low_impact	1.57	0.99	neutral	0.34	neutral	2.66	20.50	deleterious	0.26709301	0.85	0.66	disease	0.49	neutral	0.7	disease	0.52	disease	0	0.99	deleterious	0.12	neutral	-2	neutral	0.77	deleterious	-2.65	low_impact	-0.02	medium_impact	0.25	medium_impact	0.62	0.85	4.41	7.72	0.49	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10111	10111	T	A	MI.15070	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	53	18	M	K	aTa/aAa	0.36	0	0	possibly_damaging	0.88	deleterious	0.02	neutral	0.92	neutral	-1.89	deleterious	-3.69	medium_impact	2.99	0.76	neutral	0.48	neutral	3.89	23.50	deleterious	0.06	0.35	0.42	neutral	0.77	disease	0.68	disease	0.78	disease	6	0.99	deleterious	0.07	neutral	4	deleterious	0.70	deleterious	-1.5	low_impact	-0.75	medium_impact	1.63	medium_impact	0.19	0.8	16.52	10.1	0.41	N	0.86	disease_causing	1	0.61	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10112	10112	A	C	MI.15071	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	54	18	M	I	atA/atC	1.05	0	0	possibly_damaging	0.82	neutral	0.49	neutral	1.13	neutral	1.24	neutral	0.9	neutral_impact	-0.14	0.77	neutral	1	neutral	0.42	6.76	deleterious	0.19	0.45	0.09	neutral	0.26	neutral	0.3	neutral	0.41	neutral	2	0.8	neutral	0.34	neutral	-3	neutral	0.52	deleterious	-1.31	low_impact	0.18	medium_impact	-1.24	low_impact	0.20	0.8	16.52	10.1	0.36	N	0.10	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10112	10112	A	T	MI.15072	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	54	18	M	I	atA/atT	1.05	0	0	possibly_damaging	0.82	neutral	0.49	neutral	1.13	neutral	1.24	neutral	0.9	neutral_impact	-0.14	0.77	neutral	1	neutral	0.47	7.23	deleterious	0.19	0.45	0.09	neutral	0.26	neutral	0.3	neutral	0.41	neutral	2	0.8	neutral	0.34	neutral	-3	neutral	0.52	deleterious	-1.31	low_impact	0.18	medium_impact	-1.24	low_impact	0.20	0.8	16.52	10.1	0.36	N	0.10	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10113	10113	A	G	MI.15073	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	55	19	I	V	Att/Gtt	-5.19	0	0	benign	0.04	neutral	0.35	neutral	0.96	neutral	-0.33	neutral	-0.02	neutral_impact	0.8	0.79	neutral	0.96	neutral	-0.42	0.35	neutral	0.47	0.55	0.15	neutral	0.14	neutral	0.36	neutral	0.32	neutral	4	0.63	neutral	0.66	deleterious	-6	neutral	0.12	neutral	0.53	medium_impact	0.04	medium_impact	-0.38	medium_impact	0.30	0.8	3.48	8.85	0.39	N	0.49	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10113	10113	A	T	MI.15074	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	55	19	I	F	Att/Ttt	-5.19	0	0	benign	0.4	neutral	0.56	neutral	0.88	neutral	-1.15	neutral	-1.74	neutral_impact	0.78	0.76	neutral	0.93	neutral	0.73	8.99	deleterious	0.2	0.45	0.14	neutral	0.45	neutral	0.35	neutral	0.43	neutral	1	0.39	neutral	0.58	deleterious	-6	neutral	0.36	neutral	-0.56	medium_impact	0.25	medium_impact	-0.39	medium_impact	0.44	0.8	3.48	8.85	0.31	N	0.42	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10113	10113	A	C	MI.15075	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	55	19	I	L	Att/Ctt	-5.19	0	0	benign	0.04	neutral	0.89	neutral	1.01	neutral	0.07	neutral	-0.06	neutral_impact	-0.98	0.78	neutral	0.98	neutral	-0.97	0.02	neutral	0.24	0.45	0.09	neutral	0.19	neutral	0.26	neutral	0.35	neutral	3	0.04	neutral	0.93	deleterious	-6	neutral	0.11	neutral	0.53	medium_impact	0.69	medium_impact	-2.01	low_impact	0.48	0.8	3.48	8.85	0.3	N	0.18	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10114	10114	T	G	MI.15076	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	56	19	I	S	aTt/aGt	-8.2	0	0	benign	0.08	neutral	0.54	neutral	0.85	neutral	-1.66	neutral	-0.91	neutral_impact	0.56	0.82	neutral	0.97	neutral	0.76	9.23	deleterious	0.05	0.35	0.22	neutral	0.47	neutral	0.41	neutral	0.44	neutral	1	0.39	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.24	medium_impact	0.23	medium_impact	-0.6	medium_impact	0.19	0.8	3.48	8.85	0.31	N	0.25	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10114	10114	T	A	MI.15077	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	56	19	I	N	aTt/aAt	-8.2	0	0	benign	0.26	neutral	0.19	neutral	0.8	neutral	-2.92	neutral	-2.14	medium_impact	1.98	0.74	neutral	0.34	neutral	2.60	20.20	deleterious	0.12	0.4	0.45	neutral	0.63	disease	0.52	disease	0.59	disease	2	0.77	neutral	0.47	neutral	-3	neutral	0.43	deleterious	-0.31	medium_impact	-0.16	medium_impact	0.71	medium_impact	0.20	0.8	3.48	8.85	0.35	N	0.58	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10114	10114	T	C	MI.15078	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	56	19	I	T	aTt/aCt	-8.2	0	0	benign	0	neutral	0.54	neutral	0.87	neutral	-1.29	neutral	0.56	neutral_impact	-0.01	0.9	neutral	0.99	neutral	-1.02	0.01	neutral	0.22	0.45	0.17	neutral	0.14	neutral	0.31	neutral	0.24	neutral	5	0.45	neutral	0.77	deleterious	-6	neutral	0.10	neutral	1.99	medium_impact	0.23	medium_impact	-1.12	low_impact	0.24	0.8	3.48	8.85	0.32	N	0.06	polymorphism	1	0.18	rs879734442	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10115	10115	T	G	MI.15079	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	57	19	I	M	atT/atG	-1.72	0	0.01	possibly_damaging	0.6	neutral	0.69	neutral	0.85	neutral	-1.55	neutral	-0.3	neutral_impact	0.43	0.76	neutral	0.98	neutral	1.53	13.47	neutral	0.34	0.5	0.29	neutral	0.17	neutral	0.29	neutral	0.29	neutral	4	0.51	neutral	0.55	deleterious	-3	neutral	0.48	deleterious	-0.88	medium_impact	0.38	medium_impact	-0.71	medium_impact	0.54	0.8	3.48	8.85	0.31	N	0.54	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8396	8396	A	G	MI.1508	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	31	11	T	A	Acc/Gcc	-4.73	0	0	probably_damaging	0.97	neutral	0.64	neutral	1.86	neutral	-1.47	neutral	-1.88	low_impact	1.92	0.99	neutral	0.64	neutral	2.11	16.93	deleterious	0.62949060	0.85	0.32	neutral	0.11	neutral	0.56	disease	0.11	neutral	8	0.97	neutral	0.34	neutral	-2	neutral	0.67	deleterious	-2.19	low_impact	0.43	medium_impact	0.55	medium_impact	0.53	0.85	4.41	7.72	0.4	N	0.42	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10115	10115	T	A	MI.15080	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	57	19	I	M	atT/atA	-1.72	0	0.01	possibly_damaging	0.6	neutral	0.69	neutral	0.85	neutral	-1.55	neutral	-0.3	neutral_impact	0.43	0.76	neutral	0.98	neutral	1.86	15.33	deleterious	0.34	0.5	0.29	neutral	0.17	neutral	0.29	neutral	0.29	neutral	4	0.51	neutral	0.55	deleterious	-3	neutral	0.48	deleterious	-0.88	medium_impact	0.38	medium_impact	-0.71	medium_impact	0.54	0.8	3.48	8.85	0.31	N	0.54	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10116	10116	A	C	MI.15081	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	58	20	I	L	Att/Ctt	-6.35	0	0	benign	0	neutral	0.53	neutral	1.23	neutral	1.29	neutral	-1.68	low_impact	1.15	0.77	neutral	0.91	neutral	0.48	7.25	deleterious	0.22	0.45	0.15	neutral	0.28	neutral	0.31	neutral	0.44	neutral	1	0.47	neutral	0.77	deleterious	-6	neutral	0.11	neutral	1.99	medium_impact	0.22	medium_impact	-0.05	medium_impact	0.52	0.8	1.74	8.77	0.35	N	0.65	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10116	10116	A	T	MI.15082	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	58	20	I	F	Att/Ttt	-6.35	0	0	benign	0.18	neutral	0.68	neutral	0.88	neutral	-1.71	deleterious	-3.68	medium_impact	2.5	0.67	neutral	0.31	neutral	1.80	14.97	neutral	0.19	0.45	0.51	disease	0.68	disease	0.43	neutral	0.52	disease	0	0.2	neutral	0.75	deleterious	-3	neutral	0.32	neutral	-0.12	medium_impact	0.37	medium_impact	1.18	medium_impact	0.54	0.8	1.74	8.77	0.23	N	0.94	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10116	10116	A	G	MI.15083	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	58	20	I	V	Att/Gtt	-6.35	0	0	benign	0.03	neutral	0.45	neutral	1.04	neutral	0.29	neutral	-0.39	neutral_impact	0.26	0.84	neutral	0.99	neutral	-1.06	0.01	neutral	0.3	0.45	0.15	neutral	0.06	neutral	0.32	neutral	0.24	neutral	5	0.52	neutral	0.71	deleterious	-6	neutral	0.10	neutral	0.65	medium_impact	0.14	medium_impact	-0.87	medium_impact	0.35	0.8	1.74	8.77	0.42	N	0.28	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10117	10117	T	G	MI.15084	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	59	20	I	S	aTt/aGt	-0.33	0	0	benign	0.36	neutral	0.39	neutral	0.89	neutral	-1.57	deleterious	-5.15	medium_impact	2.75	0.68	neutral	0.35	neutral	2.44	19.09	deleterious	0.06	0.35	0.66	disease	0.7	disease	0.52	disease	0.6	disease	2	0.54	neutral	0.52	deleterious	-3	neutral	0.46	deleterious	-0.49	medium_impact	0.08	medium_impact	1.41	medium_impact	0.20	0.8	1.74	8.77	0.3	N	0.95	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10117	10117	T	C	MI.15085	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	59	20	I	T	aTt/aCt	-0.33	0	0	benign	0.19	neutral	0.46	neutral	0.9	neutral	-1.25	deleterious	-4.02	medium_impact	2.61	0.84	neutral	0.42	neutral	1.39	12.76	neutral	0.14	0.4	0.53	disease	0.49	neutral	0.43	neutral	0.52	disease	0	0.45	neutral	0.64	deleterious	-3	neutral	0.34	neutral	-0.15	medium_impact	0.15	medium_impact	1.28	medium_impact	0.29	0.8	1.74	8.77	0.33	N	0.94	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10117	10117	T	A	MI.15086	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	59	20	I	N	aTt/aAt	-0.33	0	0	possibly_damaging	0.65	neutral	0.06	neutral	0.85	neutral	-2.86	deleterious	-6.21	high_impact	3.65	0.79	neutral	0.41	neutral	3.92	23.50	deleterious	0.11	0.4	0.79	disease	0.78	disease	0.61	disease	0.77	disease	5	0.94	neutral	0.21	neutral	1	deleterious	0.69	deleterious	-0.96	medium_impact	-0.47	medium_impact	2.24	high_impact	0.19	0.8	1.74	8.77	0.37	N	0.99	polymorphism	1	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10118	10118	T	A	MI.15087	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	60	20	I	M	atT/atA	4.52	0.7	0	benign	0.25	neutral	0.6	neutral	0.91	neutral	-1.11	neutral	-2.38	low_impact	1.53	0.81	neutral	0.69	neutral	1.73	14.60	neutral	0.25	0.45	0.35	neutral	0.48	neutral	0.4	neutral	0.51	disease	0	0.29	neutral	0.68	deleterious	-6	neutral	0.39	neutral	-0.29	medium_impact	0.29	medium_impact	0.29	medium_impact	0.56	0.8	1.74	8.77	0.32	N	0.73	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10118	10118	T	G	MI.15088	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	60	20	I	M	atT/atG	4.52	0.7	0	benign	0.25	neutral	0.6	neutral	0.91	neutral	-1.11	neutral	-2.38	low_impact	1.53	0.81	neutral	0.69	neutral	1.44	13.00	neutral	0.25	0.45	0.35	neutral	0.48	neutral	0.4	neutral	0.51	disease	0	0.29	neutral	0.68	deleterious	-6	neutral	0.39	neutral	-0.29	medium_impact	0.29	medium_impact	0.29	medium_impact	0.56	0.8	1.74	8.77	0.31	N	0.73	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10119	10119	A	T	MI.15089	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	61	21	T	S	Aca/Tca	-6.12	0	0	benign	0.02	neutral	0.26	neutral	1.17	neutral	0.85	neutral	0.48	neutral_impact	-0.46	0.72	neutral	0.85	neutral	-1.06	0.01	neutral	0.36	0.5	0.09	neutral	0.08	neutral	0.3	neutral	0.2	neutral	6	0.73	neutral	0.62	deleterious	-6	neutral	0.11	neutral	0.81	medium_impact	-0.06	medium_impact	-1.53	low_impact	0.58	0.8	20	14.7	0.47	N	0.35	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8396	8396	A	T	MI.1509	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	31	11	T	S	Acc/Tcc	-4.73	0	0	probably_damaging	0.97	neutral	0.49	neutral	1.84	neutral	-1.87	neutral	-2.12	low_impact	1.36	1	neutral	0.63	neutral	2.50	19.48	deleterious	0.52918828	0.85	0.42	neutral	0.16	neutral	0.49	neutral	0.12	neutral	8	0.97	neutral	0.26	neutral	-2	neutral	0.66	deleterious	-2.19	low_impact	0.28	medium_impact	0.07	medium_impact	0.72	0.85	4.41	7.72	0.42	N	0.43	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10119	10119	A	G	MI.15090	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	61	21	T	A	Aca/Gca	-6.12	0	0	benign	0.15	neutral	0.37	neutral	1.07	neutral	0.64	neutral	2.24	neutral_impact	-1.74	0.79	neutral	0.95	neutral	-1.24	0.01	neutral	0.3	0.45	0.1	neutral	0.15	neutral	0.31	neutral	0.23	neutral	5	0.56	neutral	0.61	deleterious	-6	neutral	0.20	neutral	-0.04	medium_impact	0.06	medium_impact	-2.7	low_impact	0.35	0.8	20	14.7	0.26	N	0.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10119	10119	A	C	MI.15091	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	61	21	T	P	Aca/Cca	-6.12	0	0	possibly_damaging	0.49	neutral	0.05	neutral	0.95	neutral	-1.08	neutral	-1.74	neutral_impact	0.63	0.6	damaging	0.41	neutral	3.04	22.40	deleterious	0.08	0.35	0.42	neutral	0.86	disease	0.69	disease	0.81	disease	6	0.95	neutral	0.28	neutral	-3	neutral	0.66	deleterious	-0.7	medium_impact	-0.52	medium_impact	-0.53	medium_impact	0.35	0.8	20	14.7	0.32	N	0.68	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10120	10120	C	T	MI.15092	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	62	21	T	M	aCa/aTa	2.67	0.93	0	possibly_damaging	0.86	neutral	0.24	neutral	0.95	neutral	-1.76	neutral	-1.42	neutral_impact	0.43	0.86	neutral	0.68	neutral	2.64	20.50	deleterious	0.17	0.45	0.51	disease	0.53	disease	0.4	neutral	0.49	neutral	0	0.9	neutral	0.19	neutral	-3	neutral	0.68	deleterious	-1.43	low_impact	-0.09	medium_impact	-0.71	medium_impact	0.52	0.8	20	14.7	0.39	N	0.18	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10120	10120	C	A	MI.15093	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	62	21	T	K	aCa/aAa	2.67	0.93	0	benign	0.22	neutral	0.08	neutral	1	neutral	0.31	neutral	-1.59	low_impact	1.21	0.72	neutral	0.52	neutral	2.54	19.72	deleterious	0.14	0.4	0.27	neutral	0.75	disease	0.62	disease	0.72	disease	4	0.91	neutral	0.43	neutral	-6	neutral	0.37	neutral	-0.22	medium_impact	-0.4	medium_impact	0	medium_impact	0.42	0.8	20	14.7	0.42	N	0.59	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10122	10122	T	G	MI.15094	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	64	22	F	V	Ttt/Gtt	-1.95	0	0	possibly_damaging	0.82	neutral	0.5	neutral	0.97	neutral	-0.31	deleterious	-6.82	medium_impact	2.77	0.72	neutral	0.08	damaging	3.91	23.50	deleterious	0.18	0.45	0.32	neutral	0.86	disease	0.64	disease	0.74	disease	5	0.81	neutral	0.34	neutral	0	NA	0.66	deleterious	-1.31	low_impact	0.19	medium_impact	1.43	medium_impact	0.26	0.8	NA	NA	0.27	N	0.96	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10122	10122	T	A	MI.15095	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	64	22	F	I	Ttt/Att	-1.95	0	0	possibly_damaging	0.82	neutral	0.4	neutral	0.95	neutral	-0.52	deleterious	-5.82	medium_impact	2.35	0.78	neutral	0.11	damaging	4.24	23.90	deleterious	0.18	0.45	0.37	neutral	0.84	disease	0.47	neutral	0.53	disease	1	0.83	neutral	0.29	neutral	0	NA	0.68	deleterious	-1.31	low_impact	0.09	medium_impact	1.05	medium_impact	0.54	0.8	NA	NA	0.3	N	0.95	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10122	10122	T	C	MI.15096	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	64	22	F	L	Ttt/Ctt	-1.95	0	0	benign	0.12	neutral	0.65	neutral	1.03	neutral	0.21	deleterious	-5.79	medium_impact	1.94	0.81	neutral	0.18	damaging	3.85	23.40	deleterious	0.3	0.45	0.31	neutral	0.78	disease	0.46	neutral	0.52	disease	0	0.24	neutral	0.77	deleterious	-3	neutral	0.24	neutral	0.06	medium_impact	0.34	medium_impact	0.67	medium_impact	0.46	0.8	NA	NA	0.19	N	0.91	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10123	10123	T	C	MI.15097	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	65	22	F	S	tTt/tCt	3.83	1	0	probably_damaging	0.96	neutral	0.41	neutral	0.91	neutral	-1.04	deleterious	-7.84	medium_impact	2.11	0.76	neutral	0.11	damaging	4.16	23.80	deleterious	0.07	0.35	0.23	neutral	0.81	disease	0.62	disease	0.65	disease	3	0.96	neutral	0.23	neutral	1	deleterious	0.71	deleterious	-1.96	low_impact	0.1	medium_impact	0.83	medium_impact	0.23	0.8	NA	NA	0.41	N	0.97	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10123	10123	T	A	MI.15098	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	65	22	F	Y	tTt/tAt	3.83	1	0	probably_damaging	0.95	neutral	1	neutral	0.88	neutral	-1.5	deleterious	-2.95	medium_impact	2.04	0.76	neutral	0.16	damaging	4.28	24.00	deleterious	0.2	0.45	0.46	neutral	0.75	disease	0.48	neutral	0.53	disease	1	0.95	neutral	0.53	deleterious	1	deleterious	0.74	deleterious	-1.87	low_impact	1.85	high_impact	0.76	medium_impact	0.56	0.8	NA	NA	0.44	N	0.89	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10123	10123	T	G	MI.15099	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	65	22	F	C	tTt/tGt	3.83	1	0	probably_damaging	0.99	neutral	0.18	neutral	0.84	deleterious	-3.21	deleterious	-7.82	high_impact	3.78	0.74	neutral	0.09	damaging	3.97	23.60	deleterious	0.08	0.35	0.65	disease	0.87	disease	0.66	disease	0.75	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.77	deleterious	-2.52	low_impact	-0.18	medium_impact	2.36	high_impact	0.16	0.8	NA	NA	0.58	P	0.99	polymorphism	1	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8597	8597	T	G	MI.151	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	71	24	I	S	aTt/aGt	0.36	0.01	0.01	probably_damaging	0.99	neutral	0.18	neutral	3.9	deleterious	-4.47	deleterious	-4.63	low_impact	1.38	0.82	neutral	0.46	neutral	4.09	23.70	deleterious	0.37	0.65	0.27	neutral	0.57	disease	0.48	neutral	0.48	neutral	0	0.99	deleterious	0.1	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	-0.08	medium_impact	0.09	medium_impact	0.62	0.9	18.14	17.22	0.35	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8397	8397	C	T	MI.1510	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	32	11	T	I	aCc/aTc	-0.33	0	0	probably_damaging	0.99	neutral	0.52	neutral	1.96	neutral	-0.26	neutral	0.28	neutral_impact	0.41	0.98	neutral	0.97	neutral	1.49	13.26	neutral	0.51817131	0.85	0.1	neutral	0.06	neutral	0.37	neutral	0.04	neutral	9	0.99	deleterious	0.27	neutral	-2	neutral	0.64	deleterious	-2.65	low_impact	0.31	medium_impact	-0.75	medium_impact	0.76	0.85	4.41	7.72	0.43	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10124	10124	T	G	MI.15100	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	66	22	F	L	ttT/ttG	4.76	1	0	benign	0.12	neutral	0.65	neutral	1.03	neutral	0.21	deleterious	-5.79	medium_impact	1.94	0.81	neutral	0.18	damaging	4.21	23.90	deleterious	0.3	0.45	0.31	neutral	0.78	disease	0.46	neutral	0.52	disease	0	0.24	neutral	0.77	deleterious	-3	neutral	0.24	neutral	0.06	medium_impact	0.34	medium_impact	0.67	medium_impact	0.46	0.8	NA	NA	0.45	N	0.91	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10124	10124	T	A	MI.15101	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	66	22	F	L	ttT/ttA	4.76	1	0	benign	0.12	neutral	0.65	neutral	1.03	neutral	0.21	deleterious	-5.79	medium_impact	1.94	0.81	neutral	0.18	damaging	4.24	23.90	deleterious	0.3	0.45	0.31	neutral	0.78	disease	0.46	neutral	0.52	disease	0	0.24	neutral	0.77	deleterious	-3	neutral	0.24	neutral	0.06	medium_impact	0.34	medium_impact	0.67	medium_impact	0.46	0.8	NA	NA	0.45	N	0.91	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10125	10125	T	G	MI.15102	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	67	23	W	G	Tga/Gga	-1.26	0	0	probably_damaging	1	neutral	0.24	neutral	1.01	neutral	-0.24	deleterious	-12.24	medium_impact	3.39	0.75	neutral	0.08	damaging	3.77	23.40	deleterious	0.08	0.35	0.66	disease	0.84	disease	0.76	disease	0.8	disease	6	1	deleterious	0.12	neutral	1	deleterious	0.80	deleterious	-3.43	low_impact	-0.09	medium_impact	2	high_impact	0.11	0.8	5.22	9.13	0.42	N	0.97	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10125	10125	T	C	MI.15103	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	67	23	W	R	Tga/Cga	-1.26	0	0	probably_damaging	1	neutral	0.16	neutral	1.01	neutral	-0.54	deleterious	-13.11	medium_impact	3.13	0.67	neutral	0.05	damaging	3.43	23.00	deleterious	0.07	0.35	0.6	disease	0.93	disease	0.75	disease	0.83	disease	7	1	deleterious	0.08	neutral	1	deleterious	0.87	deleterious	-3.43	low_impact	-0.21	medium_impact	1.76	medium_impact	0.15	0.8	5.22	9.13	0.38	N	0.97	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10126	10126	G	T	MI.15104	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	68	23	W	L	tGa/tTa	4.52	1	0	probably_damaging	1	neutral	0.62	neutral	1.28	neutral	2.63	deleterious	-11.96	low_impact	1.31	0.83	neutral	0.1	damaging	4.09	23.70	deleterious	0.11	0.4	0.14	neutral	0.84	disease	0.61	disease	0.52	disease	0	1	deleterious	0.31	neutral	-2	neutral	0.74	deleterious	-3.43	low_impact	0.31	medium_impact	0.09	medium_impact	0.10	0.8	5.22	9.13	0.34	N	0.97	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10126	10126	G	C	MI.15105	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	68	23	W	S	tGa/tCa	4.52	1	0	probably_damaging	1	neutral	0.49	neutral	1.06	neutral	0.36	deleterious	-13.07	medium_impact	2.66	0.79	neutral	0.09	damaging	3.85	23.40	deleterious	0.09	0.4	0.51	disease	0.89	disease	0.73	disease	0.8	disease	6	1	deleterious	0.25	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.18	medium_impact	1.33	medium_impact	0.15	0.8	5.22	9.13	0.41	N	0.95	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10127	10127	A	C	MI.15106	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	69	23	W	C	tgA/tgC	3.6	1	0	probably_damaging	1	neutral	0.1	neutral	1	neutral	-1.05	deleterious	-12.11	medium_impact	3.25	0.81	neutral	0.07	damaging	3.87	23.50	deleterious	0.08	0.35	0.7	disease	0.88	disease	0.76	disease	0.79	disease	6	1	deleterious	0.05	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	-0.34	medium_impact	1.87	medium_impact	0.15	0.8	5.22	9.13	0.5	N	0.98	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10127	10127	A	T	MI.15107	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	69	23	W	C	tgA/tgT	3.6	1	0	probably_damaging	1	neutral	0.1	neutral	1	neutral	-1.05	deleterious	-12.11	medium_impact	3.25	0.81	neutral	0.07	damaging	3.98	23.60	deleterious	0.08	0.35	0.7	disease	0.88	disease	0.76	disease	0.79	disease	6	1	deleterious	0.05	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	-0.34	medium_impact	1.87	medium_impact	0.15	0.8	5.22	9.13	0.51	N	0.98	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10128	10128	C	A	MI.15108	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	70	24	L	M	Cta/Ata	1.29	0.58	0	probably_damaging	1	neutral	0.28	neutral	0.64	neutral	-2.91	neutral	-1.77	medium_impact	2.07	0.73	neutral	0.57	neutral	3.56	23.10	deleterious	0.3	0.45	0.53	disease	0.51	disease	0.31	neutral	0.47	neutral	1	1	deleterious	0.14	neutral	1	deleterious	0.74	deleterious	-3.43	low_impact	-0.04	medium_impact	0.79	medium_impact	0.53	0.8	4.35	7.79	0.39	N	0.91	polymorphism	1	0.35	rs377413998	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10128	10128	C	G	MI.15109	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	70	24	L	V	Cta/Gta	1.29	0.58	0	probably_damaging	1	neutral	0.54	neutral	0.74	neutral	-1.44	deleterious	-2.5	medium_impact	2.54	0.68	neutral	0.41	neutral	3.31	22.90	deleterious	0.25	0.45	0.41	neutral	0.59	disease	0.49	neutral	0.47	neutral	1	1	deleterious	0.27	neutral	1	deleterious	0.75	deleterious	-3.43	low_impact	0.23	medium_impact	1.22	medium_impact	0.29	0.8	4.35	7.79	0.28	N	0.89	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8397	8397	C	G	MI.1511	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	32	11	T	S	aCc/aGc	-0.33	0	0	probably_damaging	0.97	neutral	0.49	neutral	1.84	neutral	-1.87	neutral	-2.12	low_impact	1.36	1	neutral	0.63	neutral	2.13	17.03	deleterious	0.52918828	0.85	0.42	neutral	0.16	neutral	0.49	neutral	0.12	neutral	8	0.97	neutral	0.26	neutral	-2	neutral	0.66	deleterious	-2.19	low_impact	0.28	medium_impact	0.07	medium_impact	0.72	0.85	4.41	7.72	0.44	N	0.43	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10129	10129	T	A	MI.15110	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	71	24	L	Q	cTa/cAa	-1.26	0	0	probably_damaging	1	neutral	0.35	neutral	0.61	deleterious	-3.9	deleterious	-5.7	high_impact	4.12	0.61	neutral	0.23	damaging	4.12	23.80	deleterious	0.07	0.35	0.79	disease	0.79	disease	0.64	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	0.04	medium_impact	2.67	high_impact	0.18	0.8	4.35	7.79	0.34	N	0.97	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10129	10129	T	G	MI.15111	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	71	24	L	R	cTa/cGa	-1.26	0	0	probably_damaging	1	neutral	0.39	neutral	0.61	deleterious	-3.76	deleterious	-5.74	high_impact	4.46	0.66	neutral	0.18	damaging	4.06	23.70	deleterious	0.04	0.35	0.77	disease	0.9	disease	0.75	disease	0.83	disease	7	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.43	low_impact	0.08	medium_impact	2.98	high_impact	0.20	0.8	4.35	7.79	0.46	N	1.00	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10129	10129	T	C	MI.15112	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	71	24	L	P	cTa/cCa	-1.26	0	0	probably_damaging	1	neutral	0.24	neutral	0.59	deleterious	-4.66	deleterious	-6.62	high_impact	3.91	0.58	damaging	0.22	damaging	3.82	23.40	deleterious	0.04	0.35	0.84	disease	0.84	disease	0.76	disease	0.83	disease	7	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.43	low_impact	-0.09	medium_impact	2.48	high_impact	0.23	0.8	4.35	7.79	0.36	N	0.99	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10131	10131	C	G	MI.15113	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	73	25	P	A	Cca/Gca	-20	0	0	probably_damaging	1	neutral	0.34	neutral	1.07	neutral	1.34	deleterious	-7.94	low_impact	1.74	0.73	neutral	0.39	neutral	2.92	21.90	deleterious	0.33	0.5	0.23	neutral	0.43	neutral	0.44	neutral	0.38	neutral	2	1	deleterious	0.17	neutral	-2	neutral	0.70	deleterious	-3.43	low_impact	0.03	medium_impact	0.49	medium_impact	0.57	0.8	1.74	6.78	0.43	N	0.81	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10131	10131	C	A	MI.15114	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	73	25	P	T	Cca/Aca	-20	0	0	probably_damaging	1	neutral	0.25	neutral	1.04	neutral	0.81	deleterious	-7.94	medium_impact	2.23	0.74	neutral	0.16	damaging	3.55	23.10	deleterious	0.3	0.45	0.38	neutral	0.74	disease	0.32	neutral	0.51	disease	0	1	deleterious	0.13	neutral	1	deleterious	0.74	deleterious	-3.43	low_impact	-0.08	medium_impact	0.94	medium_impact	0.38	0.8	1.74	6.78	0.35	N	0.97	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10131	10131	C	T	MI.15115	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	73	25	P	S	Cca/Tca	-20	0	0	probably_damaging	1	neutral	0.29	neutral	1.16	neutral	2.17	deleterious	-7.94	low_impact	1.5	0.75	neutral	0.2	damaging	3.77	23.40	deleterious	0.28	0.45	0.16	neutral	0.75	disease	0.3	neutral	0.5	neutral	0	1	deleterious	0.15	neutral	-2	neutral	0.71	deleterious	-3.43	low_impact	-0.03	medium_impact	0.27	medium_impact	0.27	0.8	1.74	6.78	0.34	N	0.95	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10132	10132	C	G	MI.15116	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	74	25	P	R	cCa/cGa	1.29	0.74	0	probably_damaging	1	neutral	0.25	neutral	1.06	neutral	1.1	deleterious	-8.93	medium_impact	2.22	0.66	neutral	0.05	damaging	3.40	23.00	deleterious	0.14	0.4	0.58	disease	0.91	disease	0.61	disease	0.74	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.84	deleterious	-3.43	low_impact	-0.08	medium_impact	0.93	medium_impact	0.43	0.8	1.74	6.78	0.31	N	0.73	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10132	10132	C	T	MI.15117	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	74	25	P	L	cCa/cTa	1.29	0.74	0	probably_damaging	1	neutral	1	neutral	1	neutral	-0.02	deleterious	-9.92	medium_impact	3.22	0.68	neutral	0.04	damaging	4.20	23.90	deleterious	0.14	0.4	0.58	disease	0.88	disease	0.52	disease	0.72	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.81	deleterious	-3.43	low_impact	1.85	high_impact	1.84	medium_impact	0.48	0.8	1.74	6.78	0.31	N	0.97	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10132	10132	C	A	MI.15118	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	74	25	P	Q	cCa/cAa	1.29	0.74	0	probably_damaging	1	neutral	0.2	neutral	1.03	neutral	0.76	deleterious	-7.94	medium_impact	3.13	0.73	neutral	0.05	damaging	3.98	23.60	deleterious	0.21	0.45	0.58	disease	0.83	disease	0.5	neutral	0.71	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	-0.14	medium_impact	1.76	medium_impact	0.32	0.8	1.74	6.78	0.34	N	0.90	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10134	10134	C	A	MI.15119	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	76	26	Q	K	Caa/Aaa	-6.81	0	0	benign	0.43	neutral	0.74	neutral	1	neutral	0.78	deleterious	-3.8	low_impact	1.18	0.69	neutral	0.08	damaging	3.88	23.50	deleterious	0.29	0.45	0.13	neutral	0.84	disease	0.25	neutral	0.48	neutral	0	0.33	neutral	0.66	deleterious	-6	neutral	0.51	deleterious	-0.61	medium_impact	0.44	medium_impact	-0.03	medium_impact	0.33	0.8	NA	NA	0.19	N	0.96	disease_causing_automatic	0	0.49	rs587780529	Pathogenic	Leigh_syndrome	166157	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	8397	8397	C	A	MI.1512	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	32	11	T	N	aCc/aAc	-0.33	0	0	probably_damaging	0.99	neutral	0.37	neutral	1.79	deleterious	-3.45	deleterious	-3.12	medium_impact	2.27	0.99	neutral	0.62	neutral	3.38	22.90	deleterious	0.52641227	0.85	0.6	disease	0.27	neutral	0.6	disease	0.13	neutral	7	0.99	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-2.65	low_impact	0.16	medium_impact	0.85	medium_impact	0.83	0.85	4.41	7.72	0.5	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10134	10134	C	G	MI.15120	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	76	26	Q	E	Caa/Gaa	-6.81	0	0	benign	0.43	neutral	0.7	neutral	0.98	neutral	0.35	deleterious	-2.85	medium_impact	2.19	0.73	neutral	0.12	damaging	2.98	22.20	deleterious	0.35	0.5	0.28	neutral	0.8	disease	0.38	neutral	0.63	disease	3	0.34	neutral	0.64	deleterious	-3	neutral	0.53	deleterious	-0.61	medium_impact	0.39	medium_impact	0.9	medium_impact	0.45	0.8	NA	NA	0.19	N	0.93	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10135	10135	A	T	MI.15121	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	77	26	Q	L	cAa/cTa	1.52	0.01	0	benign	0.03	neutral	0.83	neutral	0.92	neutral	-0.77	deleterious	-6.58	low_impact	1.83	0.78	neutral	0.33	neutral	3.48	23.10	deleterious	0.16	0.45	0.46	neutral	0.8	disease	0.35	neutral	0.53	disease	1	0.11	neutral	0.9	deleterious	-6	neutral	0.26	neutral	0.65	medium_impact	0.57	medium_impact	0.57	medium_impact	0.18	0.8	NA	NA	0.22	N	0.97	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10135	10135	A	C	MI.15122	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	77	26	Q	P	cAa/cCa	1.52	0.01	0	possibly_damaging	0.8	neutral	0.48	neutral	0.96	neutral	0.49	deleterious	-5.74	low_impact	1.15	0.65	neutral	0.08	damaging	3.17	22.70	deleterious	0.12	0.4	0.57	disease	0.92	disease	0.4	neutral	0.68	disease	4	0.79	neutral	0.34	neutral	-3	neutral	0.78	deleterious	-1.26	low_impact	0.17	medium_impact	-0.05	medium_impact	0.30	0.8	NA	NA	0.26	N	0.96	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10135	10135	A	G	MI.15123	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	77	26	Q	R	cAa/cGa	1.52	0.01	0	possibly_damaging	0.63	neutral	0.56	neutral	0.93	neutral	0.11	deleterious	-3.78	medium_impact	1.98	0.66	neutral	0.09	damaging	3.27	22.80	deleterious	0.29	0.45	0.25	neutral	0.89	disease	0.43	neutral	0.75	disease	5	0.58	neutral	0.47	neutral	0	NA	0.66	deleterious	-0.93	medium_impact	0.25	medium_impact	0.71	medium_impact	0.33	0.8	NA	NA	0.26	N	0.85	polymorphism	1	0.49	rs28754574	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10136	10136	A	T	MI.15124	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	78	26	Q	H	caA/caT	1.75	0.01	0	probably_damaging	0.93	neutral	0.58	neutral	0.89	neutral	-1.31	deleterious	-4.52	low_impact	1.53	0.83	neutral	0.73	neutral	2.33	18.35	deleterious	0.22	0.45	0.5	disease	0.79	disease	0.28	neutral	0.48	neutral	0	0.92	neutral	0.33	neutral	-2	neutral	0.77	deleterious	-1.73	low_impact	0.27	medium_impact	0.29	medium_impact	0.41	0.8	NA	NA	0.24	N	0.93	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10136	10136	A	C	MI.15125	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	78	26	Q	H	caA/caC	1.75	0.01	0	probably_damaging	0.93	neutral	0.58	neutral	0.89	neutral	-1.31	deleterious	-4.52	low_impact	1.53	0.83	neutral	0.73	neutral	2.18	17.39	deleterious	0.22	0.45	0.5	disease	0.79	disease	0.28	neutral	0.48	neutral	0	0.92	neutral	0.33	neutral	-2	neutral	0.77	deleterious	-1.73	low_impact	0.27	medium_impact	0.29	medium_impact	0.41	0.8	NA	NA	0.24	N	0.93	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10137	10137	C	G	MI.15126	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	79	27	L	V	Ctc/Gtc	0.13	0	0	probably_damaging	1	neutral	0.5	neutral	1	neutral	-0.13	neutral	-2.09	low_impact	1.86	0.83	neutral	0.33	neutral	3.25	22.80	deleterious	0.36	0.5	0.26	neutral	0.47	neutral	0.38	neutral	0.5	neutral	0	1	deleterious	0.25	neutral	-2	neutral	0.68	deleterious	-3.43	low_impact	0.19	medium_impact	0.6	medium_impact	0.40	0.8	2.61	7.38	0.27	N	0.42	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10137	10137	C	A	MI.15127	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	79	27	L	I	Ctc/Atc	0.13	0	0	probably_damaging	1	neutral	0.42	neutral	0.98	neutral	-0.95	neutral	-1.38	low_impact	0.95	0.85	neutral	0.58	neutral	2.96	22.10	deleterious	0.3	0.45	0.27	neutral	0.33	neutral	0.2	neutral	0.45	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.68	deleterious	-3.43	low_impact	0.11	medium_impact	-0.24	medium_impact	0.33	0.8	2.61	7.38	0.35	N	0.52	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10137	10137	C	T	MI.15128	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	79	27	L	F	Ctc/Ttc	0.13	0	0	probably_damaging	1	neutral	0.69	neutral	0.99	neutral	-0.49	deleterious	-3.25	low_impact	1.94	0.75	neutral	0.09	damaging	3.79	23.40	deleterious	0.32	0.5	0.41	neutral	0.56	disease	0.41	neutral	0.51	disease	0	1	deleterious	0.35	neutral	-2	neutral	0.73	deleterious	-3.43	low_impact	0.38	medium_impact	0.67	medium_impact	0.34	0.8	2.61	7.38	0.21	N	0.65	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10138	10138	T	C	MI.15129	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	80	27	L	P	cTc/cCc	-0.8	0	0	probably_damaging	1	neutral	0.22	neutral	0.98	neutral	-0.81	deleterious	-5.46	low_impact	1.9	0.79	neutral	0.4	neutral	3.80	23.40	deleterious	0.08	0.35	0.62	disease	0.84	disease	0.44	neutral	0.72	disease	4	1	deleterious	0.11	neutral	-2	neutral	0.84	deleterious	-3.43	low_impact	-0.12	medium_impact	0.63	medium_impact	0.25	0.8	2.61	7.38	0.27	N	0.94	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8399	8399	A	G	MI.1513	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	34	12	M	V	Ata/Gta	-7.74	0	0	benign	0	neutral	0.26	neutral	2.02	neutral	0.25	neutral	0.46	neutral_impact	-1.28	1	neutral	0.94	neutral	-1.26	0.01	neutral	0.62618842	0.85	0.26	neutral	0.21	neutral	0.46	neutral	0.11	neutral	8	0.74	neutral	0.63	deleterious	-6	neutral	0.17	neutral	2.09	high_impact	0.04	medium_impact	-2.19	low_impact	0.60	0.85	NA	NA	0.45	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10138	10138	T	A	MI.15130	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	80	27	L	H	cTc/cAc	-0.8	0	0	probably_damaging	1	neutral	0.53	neutral	0.99	neutral	-0.33	deleterious	-5.82	low_impact	1.47	0.72	neutral	0.07	damaging	4.17	23.80	deleterious	0.17	0.45	0.59	disease	0.67	disease	0.42	neutral	0.52	disease	0	1	deleterious	0.27	neutral	-2	neutral	0.77	deleterious	-3.43	low_impact	0.22	medium_impact	0.24	medium_impact	0.15	0.8	2.61	7.38	0.21	N	0.86	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10138	10138	T	G	MI.15131	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	80	27	L	R	cTc/cGc	-0.8	0	0	probably_damaging	1	neutral	0.34	neutral	1.05	neutral	1.08	deleterious	-4.99	neutral_impact	0.43	0.69	neutral	0.05	damaging	4.13	23.80	deleterious	0.12	0.4	0.41	neutral	0.84	disease	0.33	neutral	0.56	disease	1	1	deleterious	0.17	neutral	-2	neutral	0.80	deleterious	-3.43	low_impact	0.03	medium_impact	-0.71	medium_impact	0.21	0.8	2.61	7.38	0.22	N	0.97	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10140	10140	A	G	MI.15132	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	82	28	N	D	Aac/Gac	-1.95	0	0	possibly_damaging	0.72	neutral	0.27	neutral	0.94	neutral	-0.69	deleterious	-3.89	medium_impact	2.21	0.85	neutral	0.2	damaging	3.36	22.90	deleterious	0.68	0.7	0.34	neutral	0.67	disease	0.47	neutral	0.51	disease	0	0.8	neutral	0.28	neutral	0	NA	0.60	deleterious	-1.09	low_impact	-0.05	medium_impact	0.92	medium_impact	0.35	0.8	3.48	9.24	0.38	N	0.77	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10140	10140	A	T	MI.15133	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	82	28	N	Y	Aac/Tac	-1.95	0	0	benign	0.08	neutral	1	neutral	0.88	neutral	-2.49	deleterious	-4.68	low_impact	1.68	0.86	neutral	0.87	neutral	0.53	7.68	deleterious	0.26	0.45	0.61	disease	0.74	disease	0.33	neutral	0.53	disease	1	0.08	neutral	0.96	deleterious	-6	neutral	0.27	neutral	0.24	medium_impact	1.85	high_impact	0.43	medium_impact	0.23	0.8	3.48	9.24	0.21	N	0.08	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10140	10140	A	C	MI.15134	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	82	28	N	H	Aac/Cac	-1.95	0	0	possibly_damaging	0.87	neutral	0.53	neutral	0.88	neutral	-1.68	deleterious	-3.16	medium_impact	2.48	0.84	neutral	0.3	neutral	2.65	20.50	deleterious	0.58	0.65	0.53	disease	0.67	disease	0.35	neutral	0.53	disease	1	0.86	neutral	0.33	neutral	0	NA	0.70	deleterious	-1.46	low_impact	0.22	medium_impact	1.17	medium_impact	0.14	0.8	3.48	9.24	0.28	N	0.42	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10141	10141	A	G	MI.15135	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	83	28	N	S	aAc/aGc	0.59	0	0	benign	0.15	neutral	0.54	neutral	1	neutral	0.13	deleterious	-3.51	low_impact	1.01	0.78	neutral	0.4	neutral	0.24	5.05	deleterious	0.75	0.8	0.26	neutral	0.4	neutral	0.29	neutral	0.44	neutral	1	0.36	neutral	0.7	deleterious	-6	neutral	0.20	neutral	-0.04	medium_impact	0.23	medium_impact	-0.18	medium_impact	0.39	0.8	3.48	9.24	0.26	N	0.61	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10141	10141	A	T	MI.15136	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	83	28	N	I	aAc/aTc	0.59	0	0	possibly_damaging	0.88	neutral	0.41	neutral	0.87	neutral	-1.72	deleterious	-6.72	medium_impact	1.97	0.84	neutral	0.19	damaging	3.58	23.20	deleterious	0.28	0.45	0.5	disease	0.81	disease	0.41	neutral	0.67	disease	3	0.88	neutral	0.27	neutral	0	NA	0.72	deleterious	-1.5	low_impact	0.1	medium_impact	0.7	medium_impact	0.33	0.8	3.48	9.24	0.29	N	0.90	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10141	10141	A	C	MI.15137	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	83	28	N	T	aAc/aCc	0.59	0	0	possibly_damaging	0.64	neutral	0.45	neutral	0.94	neutral	-0.5	deleterious	-4.36	medium_impact	2.02	0.81	neutral	0.36	neutral	1.78	14.86	neutral	0.53	0.6	0.21	neutral	0.41	neutral	0.26	neutral	0.44	neutral	1	0.64	neutral	0.41	neutral	0	NA	0.49	deleterious	-0.94	medium_impact	0.14	medium_impact	0.74	medium_impact	0.28	0.8	3.48	9.24	0.31	N	0.65	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10142	10142	C	A	MI.15138	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	84	28	N	K	aaC/aaA	0.36	0	0	possibly_damaging	0.72	neutral	0.53	neutral	1.04	neutral	0.68	deleterious	-4.46	low_impact	1.5	0.81	neutral	0.34	neutral	4.00	23.60	deleterious	0.56	0.6	0.29	neutral	0.66	disease	0.34	neutral	0.47	neutral	1	0.69	neutral	0.41	neutral	-3	neutral	0.61	deleterious	-1.09	low_impact	0.22	medium_impact	0.27	medium_impact	0.46	0.8	3.48	9.24	0.23	N	0.82	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10142	10142	C	G	MI.15139	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	84	28	N	K	aaC/aaG	0.36	0	0	possibly_damaging	0.72	neutral	0.53	neutral	1.04	neutral	0.68	deleterious	-4.46	low_impact	1.5	0.81	neutral	0.34	neutral	3.49	23.10	deleterious	0.56	0.6	0.29	neutral	0.66	disease	0.34	neutral	0.47	neutral	1	0.69	neutral	0.41	neutral	-3	neutral	0.61	deleterious	-1.09	low_impact	0.22	medium_impact	0.27	medium_impact	0.46	0.8	3.48	9.24	0.23	N	0.82	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8399	8399	A	C	MI.1514	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	34	12	M	L	Ata/Cta	-7.74	0	0	benign	0	neutral	0.89	neutral	2.06	neutral	0.75	neutral	-0.42	neutral_impact	0.27	0.99	neutral	0.44	neutral	-0.87	0.03	neutral	0.54903459	0.85	0.25	neutral	0.25	neutral	0.59	disease	0.13	neutral	7	0.1	neutral	0.95	deleterious	-6	neutral	0.17	neutral	2.09	high_impact	0.8	medium_impact	-0.87	medium_impact	0.65	0.85	NA	NA	0.34	N	0.38	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10143	10143	G	A	MI.15140	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	85	29	G	S	Ggc/Agc	-2.42	0	0	benign	0	neutral	0.92	neutral	1.06	neutral	0.43	neutral	1.97	neutral_impact	-0.84	0.89	neutral	0.95	neutral	0.28	5.51	deleterious	0.31	0.45	0.11	neutral	0.34	neutral	0.23	neutral	0.43	neutral	1	0.07	neutral	0.96	deleterious	-6	neutral	0.12	neutral	1.99	medium_impact	0.78	medium_impact	-1.88	low_impact	0.48	0.8	20	10.89	0.2	N	0.02	polymorphism	1	0.15	rs202131419	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10143	10143	G	C	MI.15141	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	85	29	G	R	Ggc/Cgc	-2.42	0	0	benign	0.14	neutral	0.59	neutral	1.03	neutral	0.26	neutral	0.76	neutral_impact	-0.14	0.7	neutral	0.51	neutral	0.57	7.93	deleterious	0.16	0.45	0.2	neutral	0.76	disease	0.53	disease	0.67	disease	3	0.3	neutral	0.73	deleterious	-6	neutral	0.26	neutral	-0.01	medium_impact	0.28	medium_impact	-1.24	low_impact	0.50	0.8	20	10.89	0.27	N	0.10	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10143	10143	G	T	MI.15142	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	85	29	G	C	Ggc/Tgc	-2.42	0	0	possibly_damaging	0.62	neutral	0.09	neutral	0.96	deleterious	-3.13	neutral	1.5	low_impact	1.04	0.68	neutral	0.42	neutral	2.55	19.78	deleterious	0.12	0.4	0.38	neutral	0.7	disease	0.5	neutral	0.52	disease	0	0.91	neutral	0.24	neutral	-3	neutral	0.46	deleterious	-0.91	medium_impact	-0.37	medium_impact	-0.16	medium_impact	0.16	0.8	20	10.89	0.37	N	0.15	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10144	10144	G	C	MI.15143	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	86	29	G	A	gGc/gCc	-1.95	0	0	benign	0.02	neutral	0.83	neutral	1.06	neutral	0.36	neutral	2.31	neutral_impact	-0.38	0.78	neutral	0.9	neutral	-0.59	0.13	neutral	0.29	0.45	0.11	neutral	0.34	neutral	0.34	neutral	0.43	neutral	1	0.13	neutral	0.91	deleterious	-6	neutral	0.13	neutral	0.81	medium_impact	0.57	medium_impact	-1.46	low_impact	0.28	0.8	20	10.89	0.22	N	0.06	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10144	10144	G	T	MI.15144	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	86	29	G	V	gGc/gTc	-1.95	0	0	benign	0.06	neutral	0.43	neutral	1.01	neutral	-0.59	neutral	3.54	neutral_impact	-0.48	0.83	neutral	0.96	neutral	0.32	5.92	deleterious	0.14	0.4	0.11	neutral	0.55	disease	0.4	neutral	0.44	neutral	1	0.52	neutral	0.69	deleterious	-6	neutral	0.16	neutral	0.36	medium_impact	0.12	medium_impact	-1.55	low_impact	0.21	0.8	20	10.89	0.25	N	0.05	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10144	10144	G	A	MI.15145	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	86	29	G	D	gGc/gAc	-1.95	0	0	benign	0.06	neutral	0.67	neutral	1.02	neutral	-0.19	neutral	0.34	neutral_impact	0.18	0.66	neutral	0.5	neutral	0.40	6.58	deleterious	0.14	0.4	0.25	neutral	0.69	disease	0.58	disease	0.67	disease	3	0.25	neutral	0.81	deleterious	-6	neutral	0.21	neutral	0.36	medium_impact	0.36	medium_impact	-0.94	medium_impact	0.23	0.8	20	10.89	0.28	N	0.26	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10146	10146	T	A	MI.15146	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	88	30	Y	N	Tac/Aac	-13.06	0	0	probably_damaging	1	neutral	0.5	neutral	1.05	neutral	1.43	deleterious	-7.53	low_impact	1.03	0.77	neutral	0.34	neutral	1.26	12.08	neutral	0.31	0.5	0.4	neutral	0.76	disease	0.44	neutral	0.55	disease	1	1	deleterious	0.25	neutral	-2	neutral	0.77	deleterious	-3.43	low_impact	0.19	medium_impact	-0.16	medium_impact	0.20	0.8	NA	NA	0.29	N	0.99	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10146	10146	T	C	MI.15147	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	88	30	Y	H	Tac/Cac	-13.06	0	0	probably_damaging	1	neutral	0.57	neutral	0.98	neutral	-0.53	deleterious	-4.11	medium_impact	2.98	0.72	neutral	0.08	damaging	2.24	17.76	deleterious	0.45	0.55	0.55	disease	0.6	disease	0.57	disease	0.69	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.78	deleterious	-3.43	low_impact	0.26	medium_impact	1.62	medium_impact	0.17	0.8	NA	NA	0.21	N	0.98	polymorphism	1	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10146	10146	T	G	MI.15148	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	88	30	Y	D	Tac/Gac	-13.06	0	0	probably_damaging	1	neutral	0.47	neutral	1.05	neutral	1.13	deleterious	-8.04	neutral_impact	0.52	0.65	neutral	0.44	neutral	1.33	12.43	neutral	0.19	0.45	0.1	neutral	0.12	neutral	0.42	neutral	0.26	neutral	5	1	deleterious	0.24	neutral	-2	neutral	0.64	deleterious	-3.43	low_impact	0.16	medium_impact	-0.63	medium_impact	0.21	0.8	NA	NA	0.34	N	0.97	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10147	10147	A	G	MI.15149	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	89	30	Y	C	tAc/tGc	3.6	1	0	probably_damaging	1	neutral	0.19	neutral	0.96	neutral	-2.76	deleterious	-8.01	high_impact	3.67	0.67	neutral	0.07	damaging	3.40	23.00	deleterious	0.17	0.45	0.81	disease	0.83	disease	0.65	disease	0.79	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.16	medium_impact	2.26	high_impact	0.05	0.8	NA	NA	0.52	N	1.00	polymorphism	1	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8399	8399	A	T	MI.1515	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	34	12	M	L	Ata/Tta	-7.74	0	0	benign	0	neutral	0.89	neutral	2.06	neutral	0.75	neutral	-0.42	neutral_impact	0.27	0.99	neutral	0.44	neutral	-0.69	0.08	neutral	0.54903459	0.85	0.25	neutral	0.25	neutral	0.59	disease	0.13	neutral	7	0.1	neutral	0.95	deleterious	-6	neutral	0.17	neutral	2.09	high_impact	0.8	medium_impact	-0.87	medium_impact	0.65	0.85	NA	NA	0.35	N	0.38	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10147	10147	A	C	MI.15150	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	89	30	Y	S	tAc/tCc	3.6	1	0	probably_damaging	1	neutral	0.69	neutral	1.09	neutral	1.49	deleterious	-7.68	low_impact	1.23	0.8	neutral	0.15	damaging	1.85	15.26	deleterious	0.21	0.45	0.4	neutral	0.7	disease	0.47	neutral	0.52	disease	0	1	deleterious	0.35	neutral	-2	neutral	0.77	deleterious	-3.43	low_impact	0.38	medium_impact	0.02	medium_impact	0.21	0.8	NA	NA	0.34	N	0.98	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10147	10147	A	T	MI.15151	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	89	30	Y	F	tAc/tTc	3.6	1	0	probably_damaging	1	neutral	0.72	neutral	0.98	neutral	-1.37	deleterious	-3.58	medium_impact	2.98	0.68	neutral	0.11	damaging	3.39	23.00	deleterious	0.45	0.55	0.41	neutral	0.63	disease	0.58	disease	0.65	disease	3	1	deleterious	0.36	neutral	1	deleterious	0.76	deleterious	-3.43	low_impact	0.42	medium_impact	1.62	medium_impact	0.08	0.8	NA	NA	0.46	N	0.81	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10149	10149	A	C	MI.15152	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	91	31	M	L	Ata/Cta	-2.19	0	0	benign	0.08	neutral	0.42	neutral	1.06	neutral	1.1	neutral	-0.4	neutral_impact	-0.65	0.85	neutral	0.91	neutral	1.73	14.59	neutral	0.36	0.5	0.14	neutral	0.37	neutral	0.35	neutral	0.42	neutral	2	0.53	neutral	0.67	deleterious	-6	neutral	0.16	neutral	0.24	medium_impact	0.11	medium_impact	-1.71	low_impact	0.25	0.8	11.3	7.82	0.29	N	0.44	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10149	10149	A	G	MI.15153	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	91	31	M	V	Ata/Gta	-2.19	0	0	benign	0.01	neutral	0.33	neutral	1.03	neutral	0.99	neutral	-0.21	neutral_impact	0.03	0.82	neutral	0.76	neutral	1.32	12.38	neutral	0.32	0.5	0.15	neutral	0.37	neutral	0.41	neutral	0.43	neutral	1	0.66	neutral	0.66	deleterious	-6	neutral	0.10	neutral	1.09	medium_impact	0.02	medium_impact	-1.08	low_impact	0.22	0.8	11.3	7.82	0.33	N	0.43	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10149	10149	A	T	MI.15154	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	91	31	M	L	Ata/Tta	-2.19	0	0	benign	0.08	neutral	0.42	neutral	1.06	neutral	1.1	neutral	-0.4	neutral_impact	-0.65	0.85	neutral	0.91	neutral	1.77	14.78	neutral	0.36	0.5	0.14	neutral	0.37	neutral	0.35	neutral	0.42	neutral	2	0.53	neutral	0.67	deleterious	-6	neutral	0.16	neutral	0.24	medium_impact	0.11	medium_impact	-1.71	low_impact	0.25	0.8	11.3	7.82	0.29	N	0.44	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10150	10150	T	C	MI.15155	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	92	31	M	T	aTa/aCa	-8.2	0	0	benign	0.01	neutral	0.62	neutral	1.06	neutral	1.86	neutral	1.03	neutral_impact	-1.38	0.88	neutral	0.99	neutral	0.17	4.39	deleterious	0.18	0.45	0.11	neutral	0.22	neutral	0.31	neutral	0.38	neutral	3	0.36	neutral	0.81	deleterious	-6	neutral	0.09	neutral	1.09	medium_impact	0.31	medium_impact	-2.37	low_impact	0.05	0.8	11.3	7.82	0.3	N	0.03	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10150	10150	T	A	MI.15156	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	92	31	M	K	aTa/aAa	-8.2	0	0	benign	0.31	neutral	0.98	neutral	1.12	neutral	2.72	neutral	-1.03	neutral_impact	-0.14	0.77	neutral	0.48	neutral	3.87	23.50	deleterious	0.14	0.4	0.14	neutral	0.6	disease	0.45	neutral	0.53	disease	1	0.27	neutral	0.84	deleterious	-6	neutral	0.36	neutral	-0.4	medium_impact	1.13	medium_impact	-1.24	low_impact	0.24	0.8	11.3	7.82	0.25	N	0.56	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10151	10151	A	T	MI.15157	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	93	31	M	I	atA/atT	0.13	0	0	benign	0.1	neutral	0.19	neutral	1.02	neutral	0.36	neutral	-0.59	neutral_impact	0.34	0.8	neutral	0.64	neutral	2.34	18.42	deleterious	0.25	0.45	0.18	neutral	0.33	neutral	0.4	neutral	0.44	neutral	1	0.79	neutral	0.55	deleterious	-6	neutral	0.19	neutral	0.15	medium_impact	-0.16	medium_impact	-0.8	medium_impact	0.26	0.8	11.3	7.82	0.37	N	0.37	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10151	10151	A	C	MI.15158	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	93	31	M	I	atA/atC	0.13	0	0	benign	0.1	neutral	0.19	neutral	1.02	neutral	0.36	neutral	-0.59	neutral_impact	0.34	0.8	neutral	0.64	neutral	2.25	17.86	deleterious	0.25	0.45	0.18	neutral	0.33	neutral	0.4	neutral	0.44	neutral	1	0.79	neutral	0.55	deleterious	-6	neutral	0.19	neutral	0.15	medium_impact	-0.16	medium_impact	-0.8	medium_impact	0.26	0.8	11.3	7.82	0.37	N	0.37	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10152	10152	G	A	MI.15159	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	94	32	E	K	Gaa/Aaa	-0.57	0	0	probably_damaging	1	neutral	0.94	neutral	0.85	neutral	-1.16	deleterious	-3.91	high_impact	3.5	0.59	damaging	0.07	damaging	4.44	24.20	deleterious	0.15	0.4	0.43	neutral	0.89	disease	0.73	disease	0.73	disease	5	1	deleterious	0.47	deleterious	2	deleterious	0.86	deleterious	-3.43	low_impact	0.85	medium_impact	2.1	high_impact	0.52	0.8	2.61	6.78	0.35	N	0.90	polymorphism	1	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8400	8400	T	A	MI.1516	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	35	12	M	K	aTa/aAa	3.14	0.03	0	benign	0.01	neutral	0.09	neutral	1.92	neutral	-2.67	neutral	-2.2	low_impact	1.24	0.99	neutral	0.36	neutral	0.77	9.27	deleterious	0.20000037	0.85	0.33	neutral	0.46	neutral	0.69	disease	0.26	neutral	5	0.91	neutral	0.54	deleterious	-6	neutral	0.24	neutral	1.14	medium_impact	-0.28	medium_impact	-0.04	medium_impact	0.59	0.85	NA	NA	0.56	N	0.56	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10152	10152	G	C	MI.15160	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	94	32	E	Q	Gaa/Caa	-0.57	0	0	probably_damaging	1	neutral	0.55	neutral	0.81	neutral	-1.69	deleterious	-2.9	medium_impact	3.06	0.59	damaging	0.14	damaging	3.22	22.70	deleterious	0.51	0.6	0.37	neutral	0.75	disease	0.62	disease	0.49	neutral	0	1	deleterious	0.28	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.24	medium_impact	1.7	medium_impact	0.39	0.8	2.61	6.78	0.28	N	0.81	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10153	10153	A	G	MI.15161	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	95	32	E	G	gAa/gGa	7.3	1	0	probably_damaging	1	neutral	0.29	neutral	0.77	neutral	-2.46	deleterious	-6.76	medium_impact	3.38	0.54	damaging	0.15	damaging	3.98	23.60	deleterious	0.27	0.45	0.53	disease	0.78	disease	0.69	disease	0.68	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	-0.03	medium_impact	1.99	medium_impact	0.21	0.8	2.61	6.78	0.59	P	0.85	polymorphism	1	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10153	10153	A	C	MI.15162	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	95	32	E	A	gAa/gCa	7.3	1	0	probably_damaging	1	neutral	0.61	neutral	0.82	neutral	-1.5	deleterious	-5.84	medium_impact	2.88	0.62	neutral	0.1	damaging	3.45	23.00	deleterious	0.21	0.45	0.48	neutral	0.8	disease	0.66	disease	0.68	disease	4	1	deleterious	0.31	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.3	medium_impact	1.53	medium_impact	0.42	0.8	2.61	6.78	0.5	N	0.81	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10153	10153	A	T	MI.15163	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	95	32	E	V	gAa/gTa	7.3	1	0	probably_damaging	1	neutral	0.21	neutral	0.76	neutral	-2.64	deleterious	-6.83	medium_impact	3.29	0.58	damaging	0.08	damaging	3.94	23.50	deleterious	0.13	0.4	0.69	disease	0.89	disease	0.71	disease	0.74	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.87	deleterious	-3.43	low_impact	-0.13	medium_impact	1.91	medium_impact	0.44	0.8	2.61	6.78	0.59	P	0.94	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10154	10154	A	T	MI.15164	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	96	32	E	D	gaA/gaT	8.69	1	0	probably_damaging	1	neutral	0.75	neutral	0.82	neutral	-1.48	deleterious	-2.68	medium_impact	2.94	0.68	neutral	0.66	neutral	3.71	23.30	deleterious	0.5	0.6	0.28	neutral	0.72	disease	0.47	neutral	0.46	neutral	1	1	deleterious	0.38	neutral	1	deleterious	0.76	deleterious	-3.43	low_impact	0.45	medium_impact	1.59	medium_impact	0.27	0.8	2.61	6.78	0.59	P	0.23	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10154	10154	A	C	MI.15165	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	96	32	E	D	gaA/gaC	8.69	1	0	probably_damaging	1	neutral	0.75	neutral	0.82	neutral	-1.48	deleterious	-2.68	medium_impact	2.94	0.68	neutral	0.66	neutral	3.58	23.20	deleterious	0.5	0.6	0.28	neutral	0.72	disease	0.47	neutral	0.46	neutral	1	1	deleterious	0.38	neutral	1	deleterious	0.76	deleterious	-3.43	low_impact	0.45	medium_impact	1.59	medium_impact	0.27	0.8	2.61	6.78	0.58	P	0.23	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10155	10155	A	G	MI.15166	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	97	33	K	E	Aaa/Gaa	1.75	1	0	probably_damaging	1	neutral	1	neutral	0.7	deleterious	-3.82	deleterious	-3.97	high_impact	3.71	0.57	damaging	0.04	damaging	3.68	23.30	deleterious	0.12	0.4	0.61	disease	0.84	disease	0.76	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.43	low_impact	1.85	high_impact	2.29	high_impact	0.37	0.8	1.74	6.56	0.47	N	0.86	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10155	10155	A	C	MI.15167	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	97	33	K	Q	Aaa/Caa	1.75	1	0	probably_damaging	1	neutral	0.4	neutral	0.68	deleterious	-3.96	deleterious	-3.97	high_impact	4.32	0.57	damaging	0.05	damaging	3.14	22.60	deleterious	0.2	0.45	0.61	disease	0.81	disease	0.74	disease	0.69	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.82	deleterious	-3.43	low_impact	0.09	medium_impact	2.85	high_impact	0.46	0.8	1.74	6.56	0.55	P	0.86	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10156	10156	A	C	MI.15168	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	98	33	K	T	aAa/aCa	5.68	1	0	probably_damaging	1	neutral	0.41	neutral	0.67	deleterious	-4.26	deleterious	-5.96	high_impact	3.58	0.55	damaging	0.04	damaging	3.46	23.00	deleterious	0.07	0.35	0.7	disease	0.88	disease	0.75	disease	0.7	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	0.1	medium_impact	2.17	high_impact	0.32	0.8	1.74	6.56	0.62	P	0.81	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10156	10156	A	T	MI.15169	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	98	33	K	M	aAa/aTa	5.68	1	0	probably_damaging	1	neutral	0.12	neutral	0.63	deleterious	-6.05	deleterious	-5.96	high_impact	3.97	0.58	damaging	0.03	damaging	3.71	23.30	deleterious	0.07	0.35	0.86	disease	0.84	disease	0.75	disease	0.63	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.29	medium_impact	2.53	high_impact	0.23	0.8	1.74	6.56	0.63	P	0.54	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8400	8400	T	C	MI.1517	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	35	12	M	T	aTa/aCa	3.14	0.03	0	benign	0	neutral	0.4	neutral	2.12	neutral	1.22	neutral	1.15	neutral_impact	-1.24	1	neutral	0.98	neutral	-1.89	0.00	neutral	0.47886177	0.85	0.11	neutral	0.08	neutral	0.49	neutral	0.04	neutral	9	0.6	neutral	0.7	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	0.19	medium_impact	-2.16	low_impact	0.47	0.85	NA	NA	0.45	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10157	10157	A	C	MI.15170	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	99	33	K	N	aaA/aaC	8.69	1	0	probably_damaging	1	neutral	0.33	neutral	0.65	deleterious	-4.53	deleterious	-4.97	high_impact	4.32	0.55	damaging	0.04	damaging	3.76	23.30	deleterious	0.23	0.45	0.69	disease	0.84	disease	0.71	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	0.02	medium_impact	2.85	high_impact	0.38	0.8	1.74	6.56	0.64	P	0.71	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10157	10157	A	T	MI.15171	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	99	33	K	N	aaA/aaT	8.69	1	0	probably_damaging	1	neutral	0.33	neutral	0.65	deleterious	-4.53	deleterious	-4.97	high_impact	4.32	0.55	damaging	0.04	damaging	3.84	23.40	deleterious	0.23	0.45	0.69	disease	0.84	disease	0.71	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	0.02	medium_impact	2.85	high_impact	0.38	0.8	1.74	6.56	0.64	P	0.71	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10158	10158	T	C	MI.15172	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	100	34	S	P	Tcc/Ccc	1.05	0.4	0	possibly_damaging	0.47	neutral	0.34	neutral	0.88	neutral	-2.39	neutral	-2.09	low_impact	1.78	0.2	damaging	0.42	neutral	2.25	17.84	deleterious	0.1	0.4	0.5	neutral	0.72	disease	0.48	neutral	0.42	neutral	2	0.62	neutral	0.44	neutral	-3	neutral	0.40	neutral	-0.67	medium_impact	0.03	medium_impact	0.52	medium_impact	0.13	0.8	16.52	9.67	0.95	P	0.59	disease_causing_automatic	0	0.44	rs199476117	Pathogenic	Leigh_syndrome|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency|Mitochondrial_complex_I_deficiency|not_provided	24753	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838951|MedGen:C1838979,OMIM:252010|MedGen:CN517202	MNGIE tissues	.	.	.	T10158C	Leigh Disease / MELAS	+	+	Cfrm	18	P	P	P	neutral
chrM	10158	10158	T	A	MI.15173	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	100	34	S	T	Tcc/Acc	1.05	0.4	0	benign	0	neutral	0.45	neutral	0.92	neutral	-1.1	neutral	0.1	neutral_impact	0.71	0.85	neutral	0.99	neutral	0.59	8.09	deleterious	0.3	0.45	0.16	neutral	0.28	neutral	0.24	neutral	0.44	neutral	1	0.54	neutral	0.73	deleterious	-6	neutral	0.10	neutral	1.99	medium_impact	0.14	medium_impact	-0.46	medium_impact	0.34	0.8	16.52	9.67	0.37	N	0.02	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10158	10158	T	G	MI.15174	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	100	34	S	A	Tcc/Gcc	1.05	0.4	0	benign	0	neutral	0.57	neutral	0.95	neutral	-0.57	neutral	0.51	neutral_impact	0.01	0.86	neutral	0.98	neutral	-0.20	1.10	neutral	0.31	0.45	0.16	neutral	0.18	neutral	0.22	neutral	0.29	neutral	4	0.42	neutral	0.79	deleterious	-6	neutral	0.10	neutral	1.99	medium_impact	0.26	medium_impact	-1.1	low_impact	0.28	0.8	16.52	9.67	0.31	N	0.06	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10159	10159	C	T	MI.15175	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	101	34	S	F	tCc/tTc	-3.11	0	0	possibly_damaging	0.47	neutral	0.07	neutral	0.89	neutral	-1.88	neutral	-1.61	low_impact	1.86	0.52	damaging	0.58	neutral	2.63	20.40	deleterious	0.14	0.4	0.48	neutral	0.53	disease	0.43	neutral	0.43	neutral	1	0.92	neutral	0.3	neutral	-3	neutral	0.40	neutral	-0.67	medium_impact	-0.43	medium_impact	0.6	medium_impact	0.07	0.8	16.52	9.67	0.45	N	0.73	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10159	10159	C	G	MI.15176	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	101	34	S	C	tCc/tGc	-3.11	0	0	possibly_damaging	0.73	deleterious	0.04	neutral	0.86	deleterious	-3.46	neutral	-1.3	medium_impact	2.71	0.55	damaging	0.41	neutral	3.24	22.80	deleterious	0.12	0.4	0.59	disease	0.54	disease	0.47	neutral	0.41	neutral	2	0.97	neutral	0.16	neutral	4	deleterious	0.49	deleterious	-1.11	low_impact	-0.58	medium_impact	1.38	medium_impact	0.17	0.8	16.52	9.67	0.42	N	0.58	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10159	10159	C	A	MI.15177	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	101	34	S	Y	tCc/tAc	-3.11	0	0	possibly_damaging	0.66	neutral	0.1	neutral	0.89	neutral	-1.84	neutral	-1.44	low_impact	1.25	0.79	neutral	0.77	neutral	2.45	19.17	deleterious	0.1	0.4	0.52	disease	0.49	neutral	0.33	neutral	0.4	neutral	2	0.91	neutral	0.22	neutral	-3	neutral	0.48	deleterious	-0.98	medium_impact	-0.34	medium_impact	0.04	medium_impact	0.12	0.8	16.52	9.67	0.37	N	0.70	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10161	10161	A	C	MI.15178	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	103	35	T	P	Acc/Ccc	-7.04	0	0	benign	0.15	neutral	0.34	neutral	0.9	neutral	-2.29	neutral	-2.09	medium_impact	2.74	0.44	damaging	0.41	neutral	2.03	16.41	deleterious	0.04	0.35	0.43	neutral	0.69	disease	0.58	disease	0.67	disease	3	0.6	neutral	0.6	deleterious	-3	neutral	0.35	neutral	-0.04	medium_impact	0.03	medium_impact	1.4	medium_impact	0.32	0.8	12.17	11.96	0.47	N	0.32	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10161	10161	A	G	MI.15179	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	103	35	T	A	Acc/Gcc	-7.04	0	0	benign	0.02	neutral	0.88	neutral	0.97	neutral	-0.38	neutral	-0.86	low_impact	1.4	0.66	neutral	0.75	neutral	1.99	16.14	deleterious	0.2	0.45	0.18	neutral	0.29	neutral	0.58	disease	0.4	neutral	2	0.06	neutral	0.93	deleterious	-6	neutral	0.15	neutral	0.81	medium_impact	0.67	medium_impact	0.18	medium_impact	0.33	0.8	12.17	11.96	0.33	N	0.16	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8401	8401	A	C	MI.1518	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	36	12	M	I	atA/atC	-0.57	0	0	benign	0.01	neutral	1	neutral	2.55	neutral	3.02	neutral	0.04	neutral_impact	-1.57	1	neutral	0.9	neutral	-0.93	0.02	neutral	0.60038707	0.85	0.3	neutral	0.06	neutral	0.45	neutral	0.03	neutral	9	0.01	neutral	1	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	1.98	high_impact	-2.44	low_impact	0.61	0.85	NA	NA	0.44	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10161	10161	A	T	MI.15180	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	103	35	T	S	Acc/Tcc	-7.04	0	0	benign	0	neutral	0.83	neutral	1.14	neutral	1.18	neutral	1.8	neutral_impact	-1.28	0.88	neutral	0.94	neutral	-0.88	0.03	neutral	0.27	0.45	0.13	neutral	0.03	neutral	0.27	neutral	0.17	neutral	7	0.16	neutral	0.92	deleterious	-6	neutral	0.09	neutral	1.99	medium_impact	0.57	medium_impact	-2.28	low_impact	0.36	0.8	12.17	11.96	0.3	N	0.01	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10162	10162	C	G	MI.15181	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	104	35	T	S	aCc/aGc	2.21	0.02	0	benign	0	neutral	0.83	neutral	1.14	neutral	1.18	neutral	1.8	neutral_impact	-1.28	0.88	neutral	0.94	neutral	-1.17	0.01	neutral	0.27	0.45	0.13	neutral	0.03	neutral	0.27	neutral	0.17	neutral	7	0.16	neutral	0.92	deleterious	-6	neutral	0.09	neutral	1.99	medium_impact	0.57	medium_impact	-2.28	low_impact	0.36	0.8	12.17	11.96	0.31	N	0.01	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10162	10162	C	A	MI.15182	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	104	35	T	N	aCc/aAc	2.21	0.02	0	benign	0	neutral	0.57	neutral	0.94	neutral	-0.84	neutral	1.64	low_impact	0.84	0.93	neutral	0.97	neutral	0.22	4.91	deleterious	0.3	0.45	0.18	neutral	0.55	disease	0.38	neutral	0.15	neutral	7	0.43	neutral	0.79	deleterious	-6	neutral	0.17	neutral	1.99	medium_impact	0.26	medium_impact	-0.34	medium_impact	0.29	0.8	12.17	11.96	0.27	N	0.04	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10162	10162	C	T	MI.15183	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	104	35	T	I	aCc/aTc	2.21	0.02	0	benign	0.15	neutral	0.34	neutral	0.91	neutral	-1.81	deleterious	-3.06	low_impact	1.76	0.64	neutral	0.57	neutral	2.06	16.57	deleterious	0.12	0.4	0.44	neutral	0.46	neutral	0.57	disease	0.49	neutral	0	0.6	neutral	0.6	deleterious	-6	neutral	0.30	neutral	-0.04	medium_impact	0.03	medium_impact	0.51	medium_impact	0.46	0.8	12.17	11.96	0.43	N	0.42	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10164	10164	C	T	MI.15184	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	106	36	P	S	Cct/Tct	-3.8	0	0	probably_damaging	1	neutral	1	neutral	0.91	neutral	-0.77	deleterious	-7.36	medium_impact	2.82	0.63	neutral	0.09	damaging	3.87	23.50	deleterious	0.15	0.4	0.75	disease	0.83	disease	0.65	disease	0.68	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.87	deleterious	-3.43	low_impact	1.85	high_impact	1.48	medium_impact	0.09	0.8	NA	NA	0.21	N	0.95	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10164	10164	C	G	MI.15185	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	106	36	P	A	Cct/Gct	-3.8	0	0	probably_damaging	1	neutral	0.64	neutral	0.91	neutral	-0.72	deleterious	-7.32	medium_impact	2.04	0.6	damaging	0.1	damaging	3.02	22.30	deleterious	0.17	0.45	0.72	disease	0.69	disease	0.66	disease	0.54	disease	1	1	deleterious	0.32	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.33	medium_impact	0.76	medium_impact	0.48	0.8	NA	NA	0.19	N	0.81	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10164	10164	C	A	MI.15186	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	106	36	P	T	Cct/Act	-3.8	0	0	probably_damaging	1	neutral	0.45	neutral	0.89	neutral	-0.97	deleterious	-7.46	medium_impact	2.76	0.58	damaging	0.06	damaging	3.71	23.30	deleterious	0.16	0.45	0.8	disease	0.87	disease	0.69	disease	0.66	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.87	deleterious	-3.43	low_impact	0.14	medium_impact	1.42	medium_impact	0.39	0.8	NA	NA	0.22	N	0.97	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10165	10165	C	G	MI.15187	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	107	36	P	R	cCt/cGt	3.6	0.99	0	probably_damaging	1	neutral	0.39	neutral	0.82	neutral	-2.23	deleterious	-8.47	high_impact	4.67	0.61	neutral	0.05	damaging	3.59	23.20	deleterious	0.08	0.35	0.85	disease	0.88	disease	0.76	disease	0.64	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.43	low_impact	0.08	medium_impact	3.17	high_impact	0.25	0.8	NA	NA	0.67	P	0.73	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10165	10165	C	T	MI.15188	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	107	36	P	L	cCt/cTt	3.6	0.99	0	probably_damaging	1	neutral	0.56	neutral	0.85	neutral	-1.57	deleterious	-9.43	high_impact	4.33	0.53	damaging	0.04	damaging	4.28	24.00	deleterious	0.1	0.4	0.84	disease	0.86	disease	0.68	disease	0.65	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	0.25	medium_impact	2.86	high_impact	0.63	0.8	NA	NA	0.55	P	0.97	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10165	10165	C	A	MI.15189	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	107	36	P	H	cCt/cAt	3.6	0.99	0	probably_damaging	1	neutral	0.39	neutral	0.79	deleterious	-3.21	deleterious	-8.5	high_impact	4.67	0.54	damaging	0.04	damaging	3.96	23.60	deleterious	0.1	0.4	0.92	disease	0.84	disease	0.74	disease	0.64	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.88	deleterious	-3.43	low_impact	0.08	medium_impact	3.17	high_impact	0.22	0.8	NA	NA	0.61	P	0.74	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8401	8401	A	T	MI.1519	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	36	12	M	I	atA/atT	-0.57	0	0	benign	0.01	neutral	1	neutral	2.55	neutral	3.02	neutral	0.04	neutral_impact	-1.57	1	neutral	0.9	neutral	-0.88	0.03	neutral	0.60038707	0.85	0.3	neutral	0.06	neutral	0.45	neutral	0.03	neutral	9	0.01	neutral	1	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	1.98	high_impact	-2.44	low_impact	0.61	0.85	NA	NA	0.43	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10167	10167	T	A	MI.15190	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	109	37	Y	N	Tac/Aac	-14.68	0	0	probably_damaging	1	neutral	0.3	neutral	0.32	deleterious	-7.37	deleterious	-8.9	high_impact	4.62	0.56	damaging	0.04	damaging	3.99	23.60	deleterious	0.04	0.35	0.77	disease	0.85	disease	0.71	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	-0.01	medium_impact	3.13	high_impact	0.07	0.8	3.48	6.65	0.4	N	0.99	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10167	10167	T	C	MI.15191	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	109	37	Y	H	Tac/Cac	-14.68	0	0	probably_damaging	1	neutral	0.51	neutral	0.34	deleterious	-5.86	deleterious	-4.95	high_impact	4.07	0.57	damaging	0.03	damaging	3.54	23.10	deleterious	0.05	0.35	0.61	disease	0.77	disease	0.76	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	0.2	medium_impact	2.62	high_impact	0.14	0.8	3.48	6.65	0.27	N	0.98	polymorphism	1	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10167	10167	T	G	MI.15192	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	109	37	Y	D	Tac/Gac	-14.68	0	0	probably_damaging	1	neutral	0.21	neutral	0.32	deleterious	-8.49	deleterious	-9.89	high_impact	4.62	0.65	neutral	0.03	damaging	3.96	23.60	deleterious	0.03	0.35	0.87	disease	0.85	disease	0.73	disease	0.64	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	-0.13	medium_impact	3.13	high_impact	0.06	0.8	3.48	6.65	0.42	N	0.97	disease_causing	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10168	10168	A	T	MI.15193	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	110	37	Y	F	tAc/tTc	7.53	1	0	probably_damaging	1	neutral	0.67	neutral	1.07	neutral	-2.77	deleterious	-3.94	low_impact	1.27	0.62	neutral	0.06	damaging	3.33	22.90	deleterious	0.14	0.4	0.16	neutral	0.53	disease	0.5	neutral	0.16	neutral	7	1	deleterious	0.34	neutral	-2	neutral	0.74	deleterious	-3.43	low_impact	0.36	medium_impact	0.06	medium_impact	0.27	0.8	3.48	6.65	0.46	N	0.81	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10168	10168	A	G	MI.15194	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	110	37	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	neutral	0.2	neutral	0.32	deleterious	-8.66	deleterious	-8.88	high_impact	4.62	0.58	damaging	0.04	damaging	3.51	23.10	deleterious	0.03	0.35	0.88	disease	0.87	disease	0.76	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	-0.14	medium_impact	3.13	high_impact	0.08	0.8	3.48	6.65	0.62	P	1.00	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10168	10168	A	C	MI.15195	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	110	37	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	neutral	0.5	neutral	0.32	deleterious	-7.12	deleterious	-8.89	high_impact	4.27	0.59	damaging	0.05	damaging	3.68	23.30	deleterious	0.04	0.35	0.75	disease	0.85	disease	0.69	disease	0.68	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	0.19	medium_impact	2.81	high_impact	0.08	0.8	3.48	6.65	0.55	P	0.98	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10170	10170	G	C	MI.15196	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	112	38	E	Q	Gag/Cag	-2.42	0	0	probably_damaging	1	neutral	0.29	neutral	-0.53	deleterious	-6.23	deleterious	-2.98	high_impact	4.92	0.4	damaging	0.08	damaging	3.35	22.90	deleterious	0.09	0.35	0.95	disease	0.73	disease	0.75	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.43	low_impact	-0.03	medium_impact	3.4	high_impact	0.42	0.8	1.74	6.81	0.69	P	0.90	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10170	10170	G	A	MI.15197	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	112	38	E	K	Gag/Aag	-2.42	0	0	probably_damaging	1	neutral	0.29	neutral	-0.51	deleterious	-5.62	deleterious	-3.97	high_impact	4.57	0.42	damaging	0.08	damaging	4.46	24.20	deleterious	0.05	0.35	0.94	disease	0.85	disease	0.81	disease	0.66	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.91	deleterious	-3.43	low_impact	-0.03	medium_impact	3.08	high_impact	0.44	0.8	1.74	6.81	0.63	P	0.99	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10171	10171	A	C	MI.15198	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	113	38	E	A	gAg/gCg	9.15	1	0	probably_damaging	1	neutral	0.5	neutral	-0.53	deleterious	-6.26	deleterious	-5.96	high_impact	4.92	0.48	damaging	0.11	damaging	3.73	23.30	deleterious	0.04	0.35	0.94	disease	0.73	disease	0.77	disease	0.68	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	0.19	medium_impact	3.4	high_impact	0.28	0.8	1.74	6.81	0.74	P	0.76	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10171	10171	A	G	MI.15199	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	113	38	E	G	gAg/gGg	9.15	1	0	probably_damaging	1	neutral	0.33	neutral	-0.53	deleterious	-6.49	deleterious	-6.95	high_impact	4.92	0.39	damaging	0.11	damaging	4.31	24.00	deleterious	0.04	0.35	0.93	disease	0.75	disease	0.78	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.43	low_impact	0.02	medium_impact	3.4	high_impact	0.12	0.8	1.74	6.81	0.82	P	0.61	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8597	8597	T	A	MI.152	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	71	24	I	N	aTt/aAt	0.36	0.01	0.01	probably_damaging	1	deleterious	0.01	neutral	3.88	deleterious	-5.67	deleterious	-5.61	medium_impact	2.66	0.87	neutral	0.51	neutral	4.23	23.90	deleterious	0.31	0.65	0.79	disease	0.63	disease	0.59	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.6	low_impact	-0.84	medium_impact	1.18	medium_impact	0.61	0.9	18.14	17.22	0.41	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8402	8402	A	T	MI.1520	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	37	13	I	F	Att/Ttt	-6.12	0	0	probably_damaging	0.97	neutral	1	neutral	2.02	deleterious	-4.63	deleterious	-3.94	medium_impact	2.22	0.98	neutral	0.1	damaging	3.51	23.10	deleterious	0.28004023	0.85	0.71	disease	0.51	disease	0.72	disease	0.65	disease	3	0.97	neutral	0.52	deleterious	1	deleterious	0.81	deleterious	-2.19	low_impact	1.98	high_impact	0.81	medium_impact	0.63	0.85	11.76	7.19	0.26	N	0.93	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10171	10171	A	T	MI.15200	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	113	38	E	V	gAg/gTg	9.15	1	0	probably_damaging	1	neutral	0.49	neutral	-0.55	deleterious	-7.6	deleterious	-6.96	high_impact	4.92	0.38	damaging	0.07	damaging	4.30	24.00	deleterious	0.03	0.35	0.97	disease	0.88	disease	0.8	disease	0.66	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.91	deleterious	-3.43	low_impact	0.18	medium_impact	3.4	high_impact	0.20	0.8	1.74	6.81	0.8	P	0.84	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10172	10172	G	C	MI.15201	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	114	38	E	D	gaG/gaC	8.69	1	0.02	probably_damaging	1	neutral	0.2	neutral	-0.48	deleterious	-4.96	deleterious	-2.98	high_impact	4.57	0.52	damaging	0.09	damaging	3.64	23.20	deleterious	0.1	0.4	0.87	disease	0.72	disease	0.72	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	-0.14	medium_impact	3.08	high_impact	0.38	0.8	1.74	6.81	0.67	P	0.86	polymorphism	0.99	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10172	10172	G	T	MI.15202	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	114	38	E	D	gaG/gaT	8.69	1	0.02	probably_damaging	1	neutral	0.2	neutral	-0.48	deleterious	-4.96	deleterious	-2.98	high_impact	4.57	0.52	damaging	0.09	damaging	3.80	23.40	deleterious	0.1	0.4	0.87	disease	0.72	disease	0.72	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	-0.14	medium_impact	3.08	high_impact	0.38	0.8	1.74	6.81	0.67	P	0.86	polymorphism	0.99	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10173	10173	T	G	MI.15203	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	115	39	C	G	Tgc/Ggc	0.82	0.99	0	probably_damaging	1	neutral	0.38	neutral	0.36	deleterious	-3.61	deleterious	-11.67	high_impact	3.96	0.57	damaging	0.1	damaging	3.32	22.90	deleterious	0.05	0.35	0.74	disease	0.86	disease	0.74	disease	0.7	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.88	deleterious	-3.43	low_impact	0.07	medium_impact	2.52	high_impact	0.10	0.8	3.48	7.4	0.52	N	0.80	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10173	10173	T	A	MI.15204	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	115	39	C	S	Tgc/Agc	0.82	0.99	0	probably_damaging	1	neutral	0.49	neutral	0.64	neutral	-1.26	deleterious	-9.71	medium_impact	2.8	0.61	neutral	0.1	damaging	3.70	23.30	deleterious	0.05	0.35	0.71	disease	0.86	disease	0.71	disease	0.7	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.87	deleterious	-3.43	low_impact	0.18	medium_impact	1.46	medium_impact	0.15	0.8	3.48	7.4	0.4	N	0.51	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10173	10173	T	C	MI.15205	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	115	39	C	R	Tgc/Cgc	0.82	0.99	0	probably_damaging	1	neutral	0.41	neutral	0.33	deleterious	-5.72	deleterious	-11.68	high_impact	4.86	0.6	damaging	0.07	damaging	3.55	23.10	deleterious	0.04	0.35	0.86	disease	0.9	disease	0.81	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.92	deleterious	-3.43	low_impact	0.1	medium_impact	3.35	high_impact	0.05	0.8	3.48	7.4	0.61	P	0.88	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10174	10174	G	C	MI.15206	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	116	39	C	S	tGc/tCc	5.68	1	0	probably_damaging	1	neutral	0.49	neutral	0.64	neutral	-1.26	deleterious	-9.71	medium_impact	2.8	0.61	neutral	0.1	damaging	3.14	22.60	deleterious	0.05	0.35	0.71	disease	0.86	disease	0.71	disease	0.7	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.87	deleterious	-3.43	low_impact	0.18	medium_impact	1.46	medium_impact	0.15	0.8	3.48	7.4	0.51	N	0.51	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10174	10174	G	T	MI.15207	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	116	39	C	F	tGc/tTc	5.68	1	0	probably_damaging	1	neutral	0.71	neutral	0.33	deleterious	-6.25	deleterious	-10.69	high_impact	4.86	0.56	damaging	0.08	damaging	3.91	23.50	deleterious	0.04	0.35	0.87	disease	0.91	disease	0.76	disease	0.62	disease	2	1	deleterious	0.36	neutral	2	deleterious	0.91	deleterious	-3.43	low_impact	0.41	medium_impact	3.35	high_impact	0.17	0.8	3.48	7.4	0.64	P	0.94	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10174	10174	G	A	MI.15208	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	116	39	C	Y	tGc/tAc	5.68	1	0	probably_damaging	1	neutral	1	neutral	0.33	deleterious	-6.66	deleterious	-10.69	high_impact	4.51	0.6	neutral	0.06	damaging	3.56	23.10	deleterious	0.05	0.35	0.9	disease	0.9	disease	0.77	disease	0.61	disease	2	1	deleterious	0.5	deleterious	2	deleterious	0.91	deleterious	-3.43	low_impact	1.85	high_impact	3.03	high_impact	0.19	0.8	3.48	7.4	0.62	P	0.93	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10175	10175	C	A	MI.15209	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	117	39	C	W	tgC/tgA	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	0.31	deleterious	-8.29	deleterious	-10.68	high_impact	4.86	0.62	neutral	0.09	damaging	4.54	24.30	deleterious	0.04	0.35	0.95	disease	0.88	disease	0.8	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.43	low_impact	-0.16	medium_impact	3.35	high_impact	0.15	0.8	3.48	7.4	0.62	P	0.94	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8402	8402	A	C	MI.1521	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	37	13	I	L	Att/Ctt	-6.12	0	0	possibly_damaging	0.85	neutral	0.76	neutral	1.96	neutral	-2.5	neutral	-1.99	low_impact	1.82	0.98	neutral	0.1	damaging	3.48	23.10	deleterious	0.34020157	0.85	0.39	neutral	0.52	disease	0.66	disease	0.63	disease	3	0.83	neutral	0.46	neutral	-3	neutral	0.59	deleterious	-1.47	low_impact	0.57	medium_impact	0.46	medium_impact	0.66	0.85	11.76	7.19	0.3	N	0.68	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10175	10175	C	G	MI.15210	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	117	39	C	W	tgC/tgG	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	0.31	deleterious	-8.29	deleterious	-10.68	high_impact	4.86	0.62	neutral	0.09	damaging	4.26	23.90	deleterious	0.04	0.35	0.95	disease	0.88	disease	0.8	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.43	low_impact	-0.16	medium_impact	3.35	high_impact	0.15	0.8	3.48	7.4	0.62	P	0.94	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10176	10176	G	C	MI.15211	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	118	40	G	R	Ggc/Cgc	-7.28	0	0	probably_damaging	1	neutral	0.35	neutral	-0.4	deleterious	-8.42	deleterious	-7.94	high_impact	4.92	0.57	damaging	0.06	damaging	3.95	23.60	deleterious	0.02	0.35	0.98	disease	0.81	disease	0.84	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.43	low_impact	0.04	medium_impact	3.4	high_impact	0.54	0.8	5.22	7.71	0.54	P	1.00	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10176	10176	G	A	MI.15212	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	118	40	G	S	Ggc/Agc	-7.28	0	0	probably_damaging	1	neutral	0.41	neutral	-0.34	deleterious	-6.53	deleterious	-5.96	high_impact	4.92	0.58	damaging	0.06	damaging	4.14	23.80	deleterious	0.03	0.35	0.95	disease	0.79	disease	0.76	disease	0.69	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.88	deleterious	-3.43	low_impact	0.1	medium_impact	3.4	high_impact	0.37	0.8	5.22	7.71	0.63	P	0.99	polymorphism	1	0.84	.	.	.	.	.	pancreatic cancer cell line	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10176	10176	G	T	MI.15213	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	118	40	G	C	Ggc/Tgc	-7.28	0	0	probably_damaging	1	neutral	0.2	neutral	-0.4	deleterious	-8.96	deleterious	-8.94	high_impact	4.92	0.54	damaging	0.03	damaging	4.19	23.80	deleterious	0.03	0.35	0.98	disease	0.83	disease	0.77	disease	0.66	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.43	low_impact	-0.14	medium_impact	3.4	high_impact	0.17	0.8	5.22	7.71	0.46	N	0.99	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10177	10177	G	C	MI.15214	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	119	40	G	A	gGc/gCc	4.99	1	0	probably_damaging	1	neutral	0.51	neutral	-0.3	deleterious	-6.06	deleterious	-5.96	high_impact	4.92	0.62	neutral	0.09	damaging	3.10	22.50	deleterious	0.04	0.35	0.94	disease	0.64	disease	0.76	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	0.2	medium_impact	3.4	high_impact	0.29	0.8	5.22	7.71	0.72	P	0.81	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10177	10177	G	T	MI.15215	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	119	40	G	V	gGc/gTc	4.99	1	0	probably_damaging	1	neutral	0.5	neutral	-0.39	deleterious	-7.92	deleterious	-8.94	high_impact	4.92	0.51	damaging	0.04	damaging	3.76	23.30	deleterious	0.03	0.35	0.98	disease	0.84	disease	0.79	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.89	deleterious	-3.43	low_impact	0.19	medium_impact	3.4	high_impact	0.15	0.8	5.22	7.71	0.6	P	0.98	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10177	10177	G	A	MI.15216	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	119	40	G	D	gGc/gAc	4.99	1	0	probably_damaging	1	neutral	0.21	neutral	-0.39	deleterious	-7.75	deleterious	-6.95	high_impact	4.92	0.59	damaging	0.04	damaging	3.77	23.40	deleterious	0.03	0.35	0.97	disease	0.83	disease	0.83	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	-0.13	medium_impact	3.4	high_impact	0.09	0.8	5.22	7.71	0.7	P	0.96	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10179	10179	T	C	MI.15217	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	121	41	F	L	Ttc/Ctc	-3.57	0	0	probably_damaging	1	neutral	0.65	neutral	0.75	neutral	-1.76	deleterious	-5.96	high_impact	3.62	0.56	damaging	0.09	damaging	4.09	23.70	deleterious	0.14	0.4	0.5	disease	0.63	disease	0.73	disease	0.68	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.34	medium_impact	2.21	high_impact	0.43	0.8	2.61	7.05	0.34	N	0.91	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10179	10179	T	G	MI.15218	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	121	41	F	V	Ttc/Gtc	-3.57	0	0	probably_damaging	1	neutral	0.51	neutral	0.77	neutral	-1.54	deleterious	-6.95	medium_impact	3.06	0.57	damaging	0.09	damaging	4.10	23.70	deleterious	0.08	0.35	0.68	disease	0.8	disease	0.75	disease	0.69	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.43	low_impact	0.2	medium_impact	1.7	medium_impact	0.12	0.8	2.61	7.05	0.28	N	0.96	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10179	10179	T	A	MI.15219	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	121	41	F	I	Ttc/Atc	-3.57	0	0	probably_damaging	1	neutral	0.39	neutral	0.76	neutral	-1.71	deleterious	-5.96	medium_impact	2.81	0.61	neutral	0.12	damaging	4.43	24.20	deleterious	0.12	0.4	0.67	disease	0.68	disease	0.74	disease	0.69	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.08	medium_impact	1.47	medium_impact	0.25	0.8	2.61	7.05	0.32	N	0.95	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8402	8402	A	G	MI.1522	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	37	13	I	V	Att/Gtt	-6.12	0	0	possibly_damaging	0.85	deleterious	0.03	neutral	1.8	neutral	-1.29	neutral	-0.99	medium_impact	2.71	0.99	neutral	0.57	neutral	2.77	21.20	deleterious	0.45672233	0.85	0.31	neutral	0.24	neutral	0.69	disease	0.24	neutral	5	0.98	deleterious	0.09	neutral	4	deleterious	0.54	deleterious	-1.47	low_impact	-0.56	medium_impact	1.23	medium_impact	0.70	0.85	11.76	7.19	0.58	P	0.39	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10180	10180	T	A	MI.15220	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	122	41	F	Y	tTc/tAc	5.68	1	0	probably_damaging	1	neutral	1	neutral	0.67	deleterious	-3.2	deleterious	-2.98	high_impact	4.08	0.61	neutral	0.1	damaging	4.27	24.00	deleterious	0.14	0.4	0.46	neutral	0.66	disease	0.68	disease	0.65	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.43	low_impact	1.85	high_impact	2.63	high_impact	0.42	0.8	2.61	7.05	0.57	P	0.89	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10180	10180	T	G	MI.15221	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	122	41	F	C	tTc/tGc	5.68	1	0	probably_damaging	1	neutral	0.22	neutral	0.65	deleterious	-4.27	deleterious	-7.95	high_impact	4.22	0.6	damaging	0.09	damaging	4.11	23.70	deleterious	0.05	0.35	0.9	disease	0.76	disease	0.77	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	-0.12	medium_impact	2.76	high_impact	0.10	0.8	2.61	7.05	0.72	P	0.99	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10180	10180	T	C	MI.15222	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	122	41	F	S	tTc/tCc	5.68	1	0	probably_damaging	1	neutral	0.41	neutral	0.7	neutral	-2.64	deleterious	-7.95	medium_impact	3.17	0.61	neutral	0.14	damaging	4.25	23.90	deleterious	0.03	0.35	0.79	disease	0.81	disease	0.7	disease	0.66	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.87	deleterious	-3.43	low_impact	0.1	medium_impact	1.8	medium_impact	0.08	0.8	2.61	7.05	0.59	P	0.97	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10181	10181	C	A	MI.15223	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	123	41	F	L	ttC/ttA	7.53	1	0.04	probably_damaging	1	neutral	0.65	neutral	0.75	neutral	-1.76	deleterious	-5.96	high_impact	3.62	0.56	damaging	0.09	damaging	4.62	24.50	deleterious	0.14	0.4	0.5	disease	0.63	disease	0.73	disease	0.68	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.34	medium_impact	2.21	high_impact	0.43	0.8	2.61	7.05	0.6	P	0.91	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10181	10181	C	G	MI.15224	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	123	41	F	L	ttC/ttG	7.53	1	0.04	probably_damaging	1	neutral	0.65	neutral	0.75	neutral	-1.76	deleterious	-5.96	high_impact	3.62	0.56	damaging	0.09	damaging	4.34	24.10	deleterious	0.14	0.4	0.5	disease	0.63	disease	0.73	disease	0.68	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.34	medium_impact	2.21	high_impact	0.43	0.8	2.61	7.05	0.6	P	0.91	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10182	10182	G	C	MI.15225	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	124	42	D	H	Gac/Cac	-1.72	0	0	probably_damaging	0.97	neutral	0.54	neutral	0.82	neutral	-2.68	deleterious	-6.93	medium_impact	3.17	0.52	damaging	0.2	damaging	3.49	23.10	deleterious	0.08	0.35	0.74	disease	0.8	disease	0.78	disease	0.69	disease	4	0.97	neutral	0.29	neutral	1	deleterious	0.85	deleterious	-2.08	low_impact	0.23	medium_impact	1.8	medium_impact	0.19	0.8	4.35	7.15	0.35	N	0.99	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10182	10182	G	A	MI.15226	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	124	42	D	N	Gac/Aac	-1.72	0	0	probably_damaging	0.95	neutral	0.3	neutral	0.88	neutral	-1.17	deleterious	-4.96	medium_impact	2.14	0.44	damaging	0.36	neutral	4.03	23.60	deleterious	0.53	0.6	0.49	neutral	0.77	disease	0.67	disease	0.55	disease	1	0.96	neutral	0.18	neutral	1	deleterious	0.81	deleterious	-1.87	low_impact	-0.01	medium_impact	0.85	medium_impact	0.63	0.8	4.35	7.15	0.47	N	0.98	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10182	10182	G	T	MI.15227	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	124	42	D	Y	Gac/Tac	-1.72	0	0	benign	0.17	neutral	1	neutral	0.8	deleterious	-3.56	deleterious	-8.92	high_impact	4.01	0.52	damaging	0.23	damaging	1.93	15.77	deleterious	0.04	0.35	0.85	disease	0.9	disease	0.77	disease	0.66	disease	3	0.17	neutral	0.92	deleterious	-2	neutral	0.46	deleterious	-0.1	medium_impact	1.85	high_impact	2.57	high_impact	0.02	0.8	4.35	7.15	0.39	N	1.00	polymorphism	1	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10183	10183	A	T	MI.15228	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	125	42	D	V	gAc/gTc	6.14	1	0	probably_damaging	0.94	neutral	0.5	neutral	0.89	neutral	-1.13	deleterious	-8.92	medium_impact	3.27	0.47	damaging	0.27	damaging	4.08	23.70	deleterious	0.04	0.35	0.79	disease	0.89	disease	0.75	disease	0.67	disease	3	0.94	neutral	0.28	neutral	1	deleterious	0.86	deleterious	-1.8	low_impact	0.19	medium_impact	1.89	medium_impact	0.01	0.8	4.35	7.15	0.66	P	0.99	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10183	10183	A	C	MI.15229	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	125	42	D	A	gAc/gCc	6.14	1	0	probably_damaging	0.94	neutral	0.5	neutral	0.87	neutral	-1.31	deleterious	-7.93	high_impact	3.66	0.59	damaging	0.37	neutral	3.90	23.50	deleterious	0.07	0.35	0.59	disease	0.79	disease	0.75	disease	0.69	disease	4	0.93	neutral	0.28	neutral	2	deleterious	0.80	deleterious	-1.8	low_impact	0.19	medium_impact	2.25	high_impact	0.21	0.8	4.35	7.15	0.66	P	0.94	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8403	8403	T	G	MI.1523	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	38	13	I	S	aTt/aGt	-0.1	0	0	probably_damaging	0.97	neutral	0.12	neutral	1.73	deleterious	-4.61	deleterious	-5.98	medium_impact	3.26	0.97	neutral	0.09	damaging	4.04	23.70	deleterious	0.23295550	0.85	0.78	disease	0.68	disease	0.73	disease	0.63	disease	3	0.99	deleterious	0.08	neutral	1	deleterious	0.84	deleterious	-2.19	low_impact	-0.2	medium_impact	1.7	medium_impact	0.51	0.85	11.76	7.19	0.43	N	0.90	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10183	10183	A	G	MI.15230	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	125	42	D	G	gAc/gGc	6.14	1	0	probably_damaging	0.95	neutral	0.34	neutral	0.82	neutral	-2.49	deleterious	-6.94	high_impact	3.75	0.52	damaging	0.37	neutral	4.34	24.00	deleterious	0.06	0.35	0.6	disease	0.81	disease	0.76	disease	0.69	disease	4	0.96	neutral	0.2	neutral	2	deleterious	0.82	deleterious	-1.87	low_impact	0.03	medium_impact	2.33	high_impact	0.16	0.8	4.35	7.15	0.67	P	0.98	polymorphism	1	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10184	10184	C	A	MI.15231	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	126	42	D	E	gaC/gaA	8.69	1	0	probably_damaging	0.92	neutral	0.28	neutral	0.95	neutral	-0.37	deleterious	-3.95	low_impact	1.88	0.51	damaging	0.33	neutral	3.92	23.50	deleterious	0.3	0.45	0.34	neutral	0.67	disease	0.63	disease	0.54	disease	1	0.94	neutral	0.18	neutral	-2	neutral	0.74	deleterious	-1.68	low_impact	-0.04	medium_impact	0.62	medium_impact	0.38	0.8	4.35	7.15	0.65	P	0.93	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10184	10184	C	G	MI.15232	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	126	42	D	E	gaC/gaG	8.69	1	0	probably_damaging	0.92	neutral	0.28	neutral	0.95	neutral	-0.37	deleterious	-3.95	low_impact	1.88	0.51	damaging	0.33	neutral	3.60	23.20	deleterious	0.3	0.45	0.34	neutral	0.67	disease	0.63	disease	0.54	disease	1	0.94	neutral	0.18	neutral	-2	neutral	0.74	deleterious	-1.68	low_impact	-0.04	medium_impact	0.62	medium_impact	0.38	0.8	4.35	7.15	0.65	P	0.93	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10185	10185	C	A	MI.15233	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	127	43	P	T	Cct/Act	-1.03	0	0	probably_damaging	1	neutral	0.39	neutral	0.83	neutral	-1.6	deleterious	-7.94	medium_impact	3.23	0.59	damaging	0.07	damaging	3.82	23.40	deleterious	0.13	0.4	0.8	disease	0.77	disease	0.72	disease	0.66	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.84	deleterious	-3.43	low_impact	0.08	medium_impact	1.85	medium_impact	0.46	0.8	2.61	6.75	0.27	N	0.97	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10185	10185	C	G	MI.15234	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	127	43	P	A	Cct/Gct	-1.03	0	0	probably_damaging	1	neutral	0.5	neutral	0.92	neutral	-1.08	deleterious	-7.94	medium_impact	2.83	0.62	neutral	0.11	damaging	3.04	22.40	deleterious	0.12	0.4	0.72	disease	0.58	disease	0.71	disease	0.67	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.19	medium_impact	1.49	medium_impact	0.58	0.8	2.61	6.75	0.28	N	0.81	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10185	10185	C	T	MI.15235	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	127	43	P	S	Cct/Tct	-1.03	0	0	probably_damaging	1	neutral	0.4	neutral	0.92	neutral	-1.52	deleterious	-7.94	medium_impact	2.4	0.63	neutral	0.09	damaging	3.83	23.40	deleterious	0.11	0.4	0.75	disease	0.77	disease	0.7	disease	0.67	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.84	deleterious	-3.43	low_impact	0.09	medium_impact	1.09	medium_impact	0.12	0.8	2.61	6.75	0.25	N	0.95	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10186	10186	C	T	MI.15236	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	128	43	P	L	cCt/cTt	4.52	0.98	0	probably_damaging	1	neutral	0.66	neutral	0.83	neutral	-1.94	deleterious	-9.93	medium_impact	3.47	0.57	damaging	0.07	damaging	4.26	23.90	deleterious	0.07	0.35	0.84	disease	0.75	disease	0.7	disease	0.66	disease	3	1	deleterious	0.33	neutral	1	deleterious	0.84	deleterious	-3.43	low_impact	0.35	medium_impact	2.07	high_impact	0.52	0.8	2.61	6.75	0.5	N	0.97	polymorphism	1	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10186	10186	C	A	MI.15237	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	128	43	P	H	cCt/cAt	4.52	0.98	0	probably_damaging	1	neutral	0.54	neutral	0.78	deleterious	-3.36	deleterious	-8.93	high_impact	4.2	0.56	damaging	0.06	damaging	3.92	23.50	deleterious	0.07	0.35	0.92	disease	0.77	disease	0.76	disease	0.67	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	0.23	medium_impact	2.74	high_impact	0.28	0.8	2.61	6.75	0.59	P	0.74	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10186	10186	C	G	MI.15238	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	128	43	P	R	cCt/cGt	4.52	0.98	0	probably_damaging	1	neutral	0.34	neutral	0.81	neutral	-2.41	deleterious	-8.93	high_impact	4.2	0.63	neutral	0.06	damaging	3.58	23.20	deleterious	0.06	0.35	0.85	disease	0.8	disease	0.77	disease	0.68	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	0.03	medium_impact	2.74	high_impact	0.24	0.8	2.61	6.75	0.66	P	0.73	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10188	10188	A	C	MI.15239	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	130	44	M	L	Ata/Cta	-11.9	0	0	benign	0	neutral	0.68	neutral	1.13	neutral	1.03	neutral	-0.44	neutral_impact	-0.26	0.85	neutral	0.96	neutral	-1.27	0.01	neutral	0.21	0.45	0.1	neutral	0.12	neutral	0.29	neutral	0.24	neutral	5	0.32	neutral	0.84	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	0.37	medium_impact	-1.35	low_impact	0.12	0.8	21.74	12.32	0.38	N	0.04	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8403	8403	T	A	MI.1524	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	38	13	I	N	aTt/aAt	-0.1	0	0	probably_damaging	0.99	deleterious	0.03	neutral	1.71	deleterious	-5.72	deleterious	-6.97	high_impact	3.6	0.97	neutral	0.12	damaging	4.30	24.00	deleterious	0.20211531	0.85	0.87	disease	0.7	disease	0.75	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-2.65	low_impact	-0.56	medium_impact	1.99	medium_impact	0.48	0.85	11.76	7.19	0.44	N	0.97	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10188	10188	A	T	MI.15240	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	130	44	M	L	Ata/Tta	-11.9	0	0	benign	0	neutral	0.68	neutral	1.13	neutral	1.03	neutral	-0.44	neutral_impact	-0.26	0.85	neutral	0.96	neutral	-1.13	0.01	neutral	0.21	0.45	0.1	neutral	0.12	neutral	0.29	neutral	0.24	neutral	5	0.32	neutral	0.84	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	0.37	medium_impact	-1.35	low_impact	0.12	0.8	21.74	12.32	0.37	N	0.04	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10188	10188	A	G	MI.15241	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	130	44	M	V	Ata/Gta	-11.9	0	0	benign	0	neutral	0.51	neutral	1.07	neutral	1.55	neutral	-1.6	low_impact	1.26	0.87	neutral	0.92	neutral	0.87	9.87	deleterious	0.24	0.45	0.17	neutral	0.48	neutral	0.44	neutral	0.33	neutral	3	0.49	neutral	0.76	deleterious	-6	neutral	0.12	neutral	1.99	medium_impact	0.2	medium_impact	0.05	medium_impact	0.18	0.8	21.74	12.32	0.37	N	0.27	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10189	10189	T	C	MI.15242	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	131	44	M	T	aTa/aCa	-0.1	0	0	benign	0.02	neutral	0.43	neutral	1.02	neutral	1.02	deleterious	-2.8	neutral_impact	0.8	0.84	neutral	0.91	neutral	-0.31	0.63	neutral	0.16	0.45	0.16	neutral	0.48	neutral	0.45	neutral	0.34	neutral	3	0.55	neutral	0.71	deleterious	-6	neutral	0.13	neutral	0.81	medium_impact	0.12	medium_impact	-0.38	medium_impact	0.10	0.8	21.74	12.32	0.31	N	0.08	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10189	10189	T	A	MI.15243	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	131	44	M	K	aTa/aAa	-0.1	0	0	benign	0.04	neutral	0.34	neutral	1.05	neutral	-0.77	deleterious	-4.18	low_impact	0.85	0.69	neutral	0.35	neutral	2.00	16.21	deleterious	0.1	0.4	0.12	neutral	0.54	disease	0.47	neutral	0.21	neutral	6	0.64	neutral	0.65	deleterious	-6	neutral	0.15	neutral	0.53	medium_impact	0.03	medium_impact	-0.33	medium_impact	0.15	0.8	21.74	12.32	0.33	N	0.68	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10190	10190	A	T	MI.15244	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	132	44	M	I	atA/atT	2.21	0.18	0	benign	0	neutral	0.41	neutral	1.05	neutral	1.05	neutral	-1.34	neutral_impact	0.53	0.84	neutral	0.87	neutral	0.42	6.82	deleterious	0.19	0.45	0.2	neutral	0.45	neutral	0.4	neutral	0.42	neutral	2	0.59	neutral	0.71	deleterious	-6	neutral	0.14	neutral	1.99	medium_impact	0.1	medium_impact	-0.62	medium_impact	0.17	0.8	21.74	12.32	0.34	N	0.25	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10190	10190	A	C	MI.15245	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	132	44	M	I	atA/atC	2.21	0.18	0	benign	0	neutral	0.41	neutral	1.05	neutral	1.05	neutral	-1.34	neutral_impact	0.53	0.84	neutral	0.87	neutral	0.39	6.54	deleterious	0.19	0.45	0.2	neutral	0.45	neutral	0.4	neutral	0.42	neutral	2	0.59	neutral	0.71	deleterious	-6	neutral	0.14	neutral	1.99	medium_impact	0.1	medium_impact	-0.62	medium_impact	0.17	0.8	21.74	12.32	0.33	N	0.25	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10191	10191	T	G	MI.15246	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	133	45	S	A	Tcc/Gcc	-0.1	0.15	0	benign	0.09	neutral	0.79	neutral	0.91	neutral	-0.27	neutral	-0.84	medium_impact	2.38	0.76	neutral	0.81	neutral	1.74	14.63	neutral	0.3	0.45	0.21	neutral	0.31	neutral	0.56	disease	0.4	neutral	2	0.11	neutral	0.85	deleterious	-3	neutral	0.15	neutral	0.19	medium_impact	0.51	medium_impact	1.07	medium_impact	0.35	0.8	25.22	17.51	0.35	N	0.10	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10191	10191	T	A	MI.15247	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	133	45	S	T	Tcc/Acc	-0.1	0.15	0	benign	0.09	neutral	0.6	neutral	0.9	neutral	-0.75	neutral	-1.76	medium_impact	2.13	0.6	damaging	0.65	neutral	1.82	15.08	deleterious	0.33	0.5	0.25	neutral	0.35	neutral	0.6	disease	0.42	neutral	2	0.31	neutral	0.76	deleterious	-3	neutral	0.16	neutral	0.19	medium_impact	0.29	medium_impact	0.84	medium_impact	0.48	0.8	25.22	17.51	0.4	N	0.13	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10191	10191	T	C	MI.15248	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	133	45	S	P	Tcc/Ccc	-0.1	0.15	0	benign	0.43	neutral	0.3	neutral	0.85	neutral	-1.41	deleterious	-2.51	medium_impact	2.88	0.17	damaging	0.35	neutral	2.31	18.21	deleterious	0.12	0.4	0.44	neutral	0.76	disease	0.6	disease	0.69	disease	4	0.66	neutral	0.44	neutral	-3	neutral	0.57	deleterious	-0.61	medium_impact	-0.01	medium_impact	1.53	medium_impact	0.22	0.8	25.22	17.51	0.95	P	0.60	disease_causing_automatic	0	0.55	rs267606890	Pathogenic	Leigh_syndrome|Mitochondrial_complex_I_deficiency	24751	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838979,OMIM:252010	.	.	.	.	T10191C	Leigh Disease / Leigh-like Disease / ESOC	-	+	Cfrm	21	P	P	P	neutral
chrM	10192	10192	C	G	MI.15249	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	134	45	S	C	tCc/tGc	3.6	1	0	possibly_damaging	0.71	neutral	0.08	neutral	0.82	deleterious	-4.12	deleterious	-3.36	medium_impact	3.23	0.69	neutral	0.43	neutral	3.22	22.70	deleterious	0.11	0.4	0.63	disease	0.6	disease	0.54	disease	0.66	disease	3	0.93	neutral	0.19	neutral	0	NA	0.62	deleterious	-1.07	low_impact	-0.4	medium_impact	1.85	medium_impact	0.27	0.8	25.22	17.51	0.6	P	0.56	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8403	8403	T	C	MI.1525	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	38	13	I	T	aTt/aCt	-0.1	0	0	probably_damaging	0.97	neutral	0.05	neutral	1.73	deleterious	-4.09	deleterious	-4.98	medium_impact	2.56	0.99	neutral	0.33	neutral	3.23	22.80	deleterious	0.34199561	0.85	0.7	disease	0.58	disease	0.69	disease	0.64	disease	3	0.99	deleterious	0.04	neutral	1	deleterious	0.83	deleterious	-2.19	low_impact	-0.43	medium_impact	1.1	medium_impact	0.55	0.85	11.76	7.19	0.62	P	0.90	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	T8403C	Episodic weakness and progressive neuropathy	+	-	Reported	1	.	P	P	damaging
chrM	10192	10192	C	A	MI.15250	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	134	45	S	Y	tCc/tAc	3.6	1	0	benign	0	neutral	0.17	neutral	0.84	neutral	-2.73	deleterious	-3.39	medium_impact	2.54	0.7	neutral	0.58	neutral	2.20	17.48	deleterious	0.09	0.35	0.43	neutral	0.59	disease	0.64	disease	0.69	disease	4	0.83	neutral	0.59	deleterious	-3	neutral	0.19	neutral	1.99	medium_impact	-0.19	medium_impact	1.22	medium_impact	0.20	0.8	25.22	17.51	0.53	N	0.06	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10192	10192	C	T	MI.15251	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	134	45	S	F	tCc/tTc	3.6	1	0	benign	0	neutral	0.14	neutral	0.84	deleterious	-3.14	deleterious	-3.55	medium_impact	2.6	0.62	neutral	0.54	neutral	2.24	17.75	deleterious	0.11	0.4	0.44	neutral	0.65	disease	0.62	disease	0.7	disease	4	0.86	neutral	0.57	deleterious	-3	neutral	0.21	neutral	1.99	medium_impact	-0.25	medium_impact	1.28	medium_impact	0.09	0.8	25.22	17.51	0.55	P	0.54	polymorphism	1	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10194	10194	C	T	MI.15252	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	136	46	P	S	Ccc/Tcc	-5.19	0	0	benign	0.26	neutral	0.94	neutral	1.12	neutral	1	neutral	3.12	neutral_impact	-2.06	0.79	neutral	0.93	neutral	1.18	11.66	neutral	0.27	0.45	0.14	neutral	0.13	neutral	0.19	neutral	0.25	neutral	5	0.18	neutral	0.84	deleterious	-6	neutral	0.24	neutral	-0.31	medium_impact	0.85	medium_impact	-3	low_impact	0.17	0.8	18.26	12.11	0.25	N	0.09	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10194	10194	C	G	MI.15253	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	136	46	P	A	Ccc/Gcc	-5.19	0	0	possibly_damaging	0.73	neutral	0.9	neutral	1.05	neutral	0.44	neutral	0.75	low_impact	1.02	0.75	neutral	0.71	neutral	3.09	22.50	deleterious	0.23	0.45	0.16	neutral	0.25	neutral	0.52	disease	0.38	neutral	2	0.69	neutral	0.59	deleterious	-3	neutral	0.56	deleterious	-1.11	low_impact	0.72	medium_impact	-0.17	medium_impact	0.56	0.8	18.26	12.11	0.3	N	0.48	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10194	10194	C	A	MI.15254	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	136	46	P	T	Ccc/Acc	-5.19	0	0	possibly_damaging	0.88	neutral	0.67	neutral	1.04	neutral	0.37	neutral	0.85	neutral_impact	0.38	0.8	neutral	0.8	neutral	2.63	20.40	deleterious	0.27	0.45	0.13	neutral	0.23	neutral	0.29	neutral	0.37	neutral	3	0.86	neutral	0.4	neutral	-3	neutral	0.60	deleterious	-1.5	low_impact	0.36	medium_impact	-0.76	medium_impact	0.46	0.8	18.26	12.11	0.26	N	0.56	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10195	10195	C	G	MI.15255	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	137	46	P	R	cCc/cGc	2.21	0.97	0	probably_damaging	0.97	neutral	0.63	neutral	1.04	neutral	0.12	neutral	-1.06	low_impact	1.57	0.75	neutral	0.45	neutral	3.61	23.20	deleterious	0.14	0.4	0.36	neutral	0.67	disease	0.59	disease	0.66	disease	3	0.97	neutral	0.33	neutral	-2	neutral	0.74	deleterious	-2.08	low_impact	0.32	medium_impact	0.33	medium_impact	0.31	0.8	18.26	12.11	0.37	N	0.76	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10195	10195	C	T	MI.15256	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	137	46	P	L	cCc/cTc	2.21	0.97	0	probably_damaging	0.94	neutral	0.79	neutral	1.03	neutral	-0.87	neutral	-1.76	low_impact	0.84	0.75	neutral	0.53	neutral	4.40	24.10	deleterious	0.16	0.45	0.36	neutral	0.4	neutral	0.51	disease	0.42	neutral	2	0.92	neutral	0.43	neutral	-2	neutral	0.69	deleterious	-1.8	low_impact	0.51	medium_impact	-0.34	medium_impact	0.56	0.8	18.26	12.11	0.39	N	0.89	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10195	10195	C	A	MI.15257	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	137	46	P	H	cCc/cAc	2.21	0.97	0	probably_damaging	0.99	neutral	0.58	neutral	0.99	neutral	-0.88	neutral	-1.08	neutral_impact	0.47	0.73	neutral	0.45	neutral	4.00	23.60	deleterious	0.17	0.45	0.51	disease	0.35	neutral	0.52	disease	0.45	neutral	1	0.99	deleterious	0.3	neutral	-2	neutral	0.71	deleterious	-2.52	low_impact	0.27	medium_impact	-0.68	medium_impact	0.26	0.8	18.26	12.11	0.42	N	0.77	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10197	10197	G	T	MI.15258	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	139	47	A	S	Gcc/Tcc	-20	0	0	probably_damaging	1	neutral	1	neutral	0.98	neutral	-1.42	deleterious	-2.76	low_impact	1.77	0.46	damaging	0.37	neutral	3.72	23.30	deleterious	0.26	0.45	0.17	neutral	0.69	disease	0.71	disease	0.36	neutral	3	1	deleterious	0.5	deleterious	-2	neutral	0.75	deleterious	-3.43	low_impact	1.85	high_impact	0.51	medium_impact	0.21	0.8	2.61	7.01	0.39	N	0.98	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10197	10197	G	A	MI.15259	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	139	47	A	T	Gcc/Acc	-20	0	0	probably_damaging	1	neutral	0.52	neutral	0.89	neutral	-1.8	deleterious	-3.52	medium_impact	2.54	0.09	damaging	0.38	neutral	4.20	23.90	deleterious	0.17	0.45	0.31	neutral	0.74	disease	0.74	disease	0.58	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.21	medium_impact	1.22	medium_impact	0.76	0.85	2.61	7.01	0.88	P	0.93	disease_causing_automatic	0	0.53	rs267606891	Pathogenic	Leigh_syndrome|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency|Leber_hereditary_optic_neuropathy_with_dystonia|not_specified	24754	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838951|MedGen:C1839040,OMIM:500001|MedGen:CN169374	.	.	.	.	G10197A	Leigh Disease / Dystonia / Stroke / LDYT	+	+	Cfrm	10	P	P	P	damaging
chrM	8404	8404	T	G	MI.1526	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	39	13	I	M	atT/atG	7.53	0.96	0	probably_damaging	0.99	neutral	0.26	neutral	1.8	deleterious	-4.37	deleterious	-2.99	low_impact	1.74	0.98	neutral	0.1	damaging	3.22	22.70	deleterious	0.34561211	0.85	0.68	disease	0.46	neutral	0.7	disease	0.45	neutral	1	0.99	deleterious	0.14	neutral	-2	neutral	0.82	deleterious	-2.65	low_impact	0.04	medium_impact	0.39	medium_impact	0.68	0.85	11.76	7.19	0.59	P	0.73	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10197	10197	G	C	MI.15260	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	139	47	A	P	Gcc/Ccc	-20	0	0	probably_damaging	1	neutral	0.32	neutral	0.82	deleterious	-3.08	deleterious	-4.73	medium_impact	2.73	0.39	damaging	0.24	damaging	3.87	23.50	deleterious	0.04	0.35	0.58	disease	0.77	disease	0.74	disease	0.7	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.84	deleterious	-3.43	low_impact	0.01	medium_impact	1.39	medium_impact	0.31	0.8	2.61	7.01	0.46	N	0.96	polymorphism	1	0.54	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10198	10198	C	G	MI.15261	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	140	47	A	G	gCc/gGc	4.99	1	0	probably_damaging	1	neutral	0.45	neutral	0.85	neutral	-2.6	deleterious	-3.84	medium_impact	3.02	0.43	damaging	0.42	neutral	4.02	23.60	deleterious	0.24	0.45	0.44	neutral	0.68	disease	0.75	disease	0.69	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.77	deleterious	-3.43	low_impact	0.14	medium_impact	1.66	medium_impact	0.60	0.8	2.61	7.01	0.81	P	0.85	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10198	10198	C	A	MI.15262	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	140	47	A	D	gCc/gAc	4.99	1	0	probably_damaging	1	neutral	0.44	neutral	0.85	neutral	-2.63	deleterious	-5.67	high_impact	4.21	0.48	damaging	0.27	damaging	4.52	24.30	deleterious	0.04	0.35	0.54	disease	0.84	disease	0.8	disease	0.71	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.80	deleterious	-3.43	low_impact	0.13	medium_impact	2.75	high_impact	0.15	0.8	2.61	7.01	0.72	P	0.96	polymorphism	1	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10198	10198	C	T	MI.15263	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	140	47	A	V	gCc/gTc	4.99	1	0	probably_damaging	1	neutral	0.42	neutral	0.91	neutral	-2.51	deleterious	-3.75	medium_impact	3.46	0.38	damaging	0.31	neutral	4.50	24.30	deleterious	0.11	0.4	0.39	neutral	0.79	disease	0.77	disease	0.69	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.78	deleterious	-3.43	low_impact	0.11	medium_impact	2.06	high_impact	0.72	0.85	2.61	7.01	0.8	P	0.79	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10200	10200	C	T	MI.15264	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	142	48	R	C	Cgc/Tgc	-12.6	0	0	probably_damaging	1	neutral	0.18	neutral	0.72	deleterious	-5.07	deleterious	-7.66	high_impact	4.82	0.57	damaging	0.04	damaging	5.02	25.20	deleterious	0.08	0.35	0.92	disease	0.8	disease	0.82	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.18	medium_impact	3.31	high_impact	0.87	0.9	3.48	7.82	0.58	P	1.00	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10200	10200	C	G	MI.15265	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	142	48	R	G	Cgc/Ggc	-12.6	0	0	probably_damaging	1	neutral	0.33	neutral	0.77	neutral	-2.15	deleterious	-6.71	medium_impact	3.46	0.58	damaging	0.07	damaging	4.23	23.90	deleterious	0.07	0.35	0.76	disease	0.68	disease	0.78	disease	0.69	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-3.43	low_impact	0.02	medium_impact	2.06	high_impact	0.16	0.8	3.48	7.82	0.31	N	0.97	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10200	10200	C	A	MI.15266	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	142	48	R	S	Cgc/Agc	-12.6	0	0	probably_damaging	1	neutral	0.48	neutral	0.83	neutral	-1.68	deleterious	-5.72	medium_impact	3.46	0.62	neutral	0.06	damaging	4.60	24.40	deleterious	0.07	0.35	0.72	disease	0.75	disease	0.77	disease	0.69	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.81	deleterious	-3.43	low_impact	0.17	medium_impact	2.06	high_impact	0.22	0.8	3.48	7.82	0.3	N	0.81	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10201	10201	G	C	MI.15267	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	143	48	R	P	cGc/cCc	1.75	0.9	0	probably_damaging	1	neutral	0.28	neutral	0.74	deleterious	-3.4	deleterious	-6.71	high_impact	4.12	0.55	damaging	0.05	damaging	4.27	24.00	deleterious	0.04	0.35	0.83	disease	0.77	disease	0.79	disease	0.67	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.04	medium_impact	2.67	high_impact	0.10	0.8	3.48	7.82	0.47	N	0.99	polymorphism	1	0.65	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10201	10201	G	T	MI.15268	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	143	48	R	L	cGc/cTc	1.75	0.9	0	probably_damaging	1	neutral	0.67	neutral	0.76	neutral	-2.43	deleterious	-6.74	high_impact	4.12	0.59	damaging	0.04	damaging	4.34	24.00	deleterious	0.06	0.35	0.76	disease	0.81	disease	0.79	disease	0.68	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	0.36	medium_impact	2.67	high_impact	0.06	0.8	3.48	7.82	0.45	N	1.00	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10201	10201	G	A	MI.15269	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	143	48	R	H	cGc/cAc	1.75	0.9	0	probably_damaging	1	neutral	0.54	neutral	0.75	neutral	-2.85	deleterious	-4.51	medium_impact	3.32	0.62	neutral	0.04	damaging	4.36	24.10	deleterious	0.2	0.45	0.81	disease	0.71	disease	0.73	disease	0.59	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.23	medium_impact	1.94	medium_impact	0.94	0.95	3.48	7.82	0.35	N	1.00	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8404	8404	T	A	MI.1527	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	39	13	I	M	atT/atA	7.53	0.96	0	probably_damaging	0.99	neutral	0.26	neutral	1.8	deleterious	-4.37	deleterious	-2.99	low_impact	1.74	0.98	neutral	0.1	damaging	3.52	23.10	deleterious	0.34561211	0.85	0.68	disease	0.46	neutral	0.7	disease	0.45	neutral	1	0.99	deleterious	0.14	neutral	-2	neutral	0.82	deleterious	-2.65	low_impact	0.04	medium_impact	0.39	medium_impact	0.68	0.85	11.76	7.19	0.59	P	0.73	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10203	10203	G	A	MI.15270	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	145	49	V	I	Gtc/Atc	-8.43	0	0	benign	0.01	neutral	0.4	neutral	1	neutral	-0.16	neutral	0.94	neutral_impact	-0.95	0.79	neutral	0.73	neutral	0.54	7.72	deleterious	0.43	0.55	0.12	neutral	0.19	neutral	0.26	neutral	0.34	neutral	3	0.59	neutral	0.7	deleterious	-6	neutral	0.12	neutral	1.09	medium_impact	0.09	medium_impact	-1.98	low_impact	0.78	0.85	18.26	13.84	0.32	N	0.08	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10203	10203	G	C	MI.15271	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	145	49	V	L	Gtc/Ctc	-8.43	0	0	benign	0.05	neutral	0.68	neutral	1.02	neutral	0.01	neutral	2.44	neutral_impact	-2.12	0.73	neutral	0.95	neutral	-1.06	0.01	neutral	0.24	0.45	0.11	neutral	0.1	neutral	0.16	neutral	0.25	neutral	5	0.25	neutral	0.82	deleterious	-6	neutral	0.10	neutral	0.44	medium_impact	0.37	medium_impact	-3.05	low_impact	0.68	0.85	18.26	13.84	0.35	N	0.03	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10203	10203	G	T	MI.15272	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	145	49	V	F	Gtc/Ttc	-8.43	0	0	possibly_damaging	0.5	neutral	0.73	neutral	0.92	neutral	-1.44	neutral	-1.23	low_impact	0.86	0.71	neutral	0.62	neutral	2.12	16.95	deleterious	0.06	0.35	0.4	neutral	0.61	disease	0.62	disease	0.65	disease	3	0.4	neutral	0.62	deleterious	-3	neutral	0.37	neutral	-0.72	medium_impact	0.43	medium_impact	-0.32	medium_impact	0.36	0.8	18.26	13.84	0.27	N	0.41	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10204	10204	T	G	MI.15273	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	146	49	V	G	gTc/gGc	-0.1	0	0	possibly_damaging	0.72	neutral	0.34	neutral	1	neutral	-0.78	deleterious	-5.08	neutral_impact	0.4	0.62	neutral	0.46	neutral	2.25	17.81	deleterious	0.05	0.35	0.71	disease	0.47	neutral	0.62	disease	0.66	disease	3	0.77	neutral	0.31	neutral	-3	neutral	0.53	deleterious	-1.09	low_impact	0.03	medium_impact	-0.74	medium_impact	0.13	0.8	18.26	13.84	0.3	N	0.66	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10204	10204	T	A	MI.15274	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	146	49	V	D	gTc/gAc	-0.1	0	0	possibly_damaging	0.81	neutral	0.21	neutral	0.92	neutral	-2.1	deleterious	-4.99	low_impact	1.41	0.57	damaging	0.45	neutral	4.14	23.80	deleterious	0.03	0.35	0.79	disease	0.66	disease	0.67	disease	0.67	disease	3	0.88	neutral	0.2	neutral	-3	neutral	0.67	deleterious	-1.29	low_impact	-0.13	medium_impact	0.18	medium_impact	0.04	0.8	18.26	13.84	0.3	N	0.69	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10204	10204	T	C	MI.15275	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	146	49	V	A	gTc/gCc	-0.1	0	0	benign	0.26	neutral	0.53	neutral	0.98	neutral	-0.51	neutral	-2.16	neutral_impact	0.56	0.6	damaging	0.68	neutral	1.72	14.51	neutral	0.17	0.45	0.4	neutral	0.27	neutral	0.58	disease	0.45	neutral	1	0.37	neutral	0.64	deleterious	-6	neutral	0.27	neutral	-0.31	medium_impact	0.22	medium_impact	-0.6	medium_impact	0.16	0.8	18.26	13.84	0.34	N	0.32	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10206	10206	C	G	MI.15276	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	148	50	P	A	Cct/Gct	-12.37	0	0	probably_damaging	1	neutral	0.54	neutral	0.94	neutral	0.39	deleterious	-7.76	medium_impact	3.14	0.56	damaging	0.06	damaging	3.08	22.50	deleterious	0.2	0.45	0.72	disease	0.65	disease	0.72	disease	0.66	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.23	medium_impact	1.77	medium_impact	0.58	0.8	3.48	6.69	0.26	N	0.81	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10206	10206	C	A	MI.15277	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	148	50	P	T	Cct/Act	-12.37	0	0	probably_damaging	1	neutral	0.42	neutral	0.91	neutral	0.21	deleterious	-7.76	medium_impact	3.35	0.55	damaging	0.03	damaging	3.71	23.30	deleterious	0.17	0.45	0.8	disease	0.78	disease	0.7	disease	0.66	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.85	deleterious	-3.43	low_impact	0.11	medium_impact	1.96	medium_impact	0.53	0.8	3.48	6.69	0.29	N	0.97	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10206	10206	C	T	MI.15278	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	148	50	P	S	Cct/Tct	-12.37	0	0	probably_damaging	1	neutral	0.46	neutral	0.94	neutral	0.47	deleterious	-7.76	medium_impact	3.02	0.57	damaging	0.04	damaging	3.92	23.50	deleterious	0.24	0.45	0.75	disease	0.81	disease	0.7	disease	0.68	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.83	deleterious	-3.43	low_impact	0.15	medium_impact	1.66	medium_impact	0.11	0.8	3.48	6.69	0.27	N	0.95	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10207	10207	C	G	MI.15279	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	149	50	P	R	cCt/cGt	7.3	1	0	probably_damaging	1	neutral	0.4	neutral	0.95	neutral	1.75	deleterious	-8.74	medium_impact	2.43	0.67	neutral	0.03	damaging	3.65	23.20	deleterious	0.09	0.35	0.85	disease	0.89	disease	0.76	disease	0.63	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.87	deleterious	-3.43	low_impact	0.09	medium_impact	1.12	medium_impact	0.29	0.8	3.48	6.69	0.54	P	0.73	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8405	8405	A	C	MI.1528	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	40	14	T	P	Acc/Ccc	-2.65	0	0	benign	0.14	neutral	0.05	neutral	1.92	neutral	-2.97	deleterious	-2.6	medium_impact	2.2	0.99	neutral	0.4	neutral	1.34	12.48	neutral	0.22335685	0.85	0.61	disease	0.58	disease	0.67	disease	0.66	disease	3	0.94	neutral	0.46	neutral	-3	neutral	0.32	neutral	-0.01	medium_impact	-0.43	medium_impact	0.79	medium_impact	0.57	0.85	NA	NA	0.46	N	0.58	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10207	10207	C	T	MI.15280	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	149	50	P	L	cCt/cTt	7.3	1	0	probably_damaging	1	neutral	0.7	neutral	0.9	neutral	-0.54	deleterious	-9.72	high_impact	4.12	0.54	damaging	0.02	damaging	4.35	24.10	deleterious	0.12	0.4	0.84	disease	0.82	disease	0.7	disease	0.64	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	0.39	medium_impact	2.67	high_impact	0.75	0.85	3.48	6.69	0.58	P	0.97	polymorphism	1	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10207	10207	C	A	MI.15281	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	149	50	P	H	cCt/cAt	7.3	1	0	probably_damaging	1	neutral	0.55	neutral	0.88	neutral	-1.02	deleterious	-8.74	high_impact	4.32	0.59	damaging	0.02	damaging	4.02	23.60	deleterious	0.12	0.4	0.92	disease	0.84	disease	0.76	disease	0.62	disease	2	1	deleterious	0.28	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	0.24	medium_impact	2.85	high_impact	0.23	0.8	3.48	6.69	0.62	P	0.74	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10209	10209	T	A	MI.15282	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	151	51	F	I	Ttc/Atc	-10.98	0	0	probably_damaging	1	neutral	0.35	neutral	0.61	neutral	-2.88	deleterious	-5.82	medium_impact	3.29	0.75	neutral	0.12	damaging	4.42	24.20	deleterious	0.06	0.35	0.67	disease	0.83	disease	0.73	disease	0.4	neutral	2	1	deleterious	0.18	neutral	1	deleterious	0.84	deleterious	-3.43	low_impact	0.04	medium_impact	1.91	medium_impact	0.30	0.8	NA	NA	0.36	N	0.95	polymorphism	1	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10209	10209	T	G	MI.15283	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	151	51	F	V	Ttc/Gtc	-10.98	0	0	probably_damaging	1	neutral	0.48	neutral	0.65	neutral	-2.84	deleterious	-6.8	high_impact	3.61	0.7	neutral	0.08	damaging	4.17	23.80	deleterious	0.05	0.35	0.68	disease	0.88	disease	0.78	disease	0.71	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	0.17	medium_impact	2.2	high_impact	0.27	0.8	NA	NA	0.36	N	0.96	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10209	10209	T	C	MI.15284	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	151	51	F	L	Ttc/Ctc	-10.98	0	0	probably_damaging	1	neutral	0.59	neutral	0.64	neutral	-2.2	deleterious	-5.82	medium_impact	3.44	0.79	neutral	0.11	damaging	4.05	23.70	deleterious	0.05	0.35	0.5	disease	0.73	disease	0.72	disease	0.57	disease	1	1	deleterious	0.3	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.28	medium_impact	2.05	high_impact	0.61	0.8	NA	NA	0.3	N	0.91	polymorphism	1	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10210	10210	T	C	MI.15285	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	152	51	F	S	tTc/tCc	3.83	1	0	probably_damaging	1	neutral	0.84	neutral	0.49	deleterious	-4.08	deleterious	-7.76	high_impact	4.16	0.73	neutral	0.08	damaging	4.24	23.90	deleterious	0.02	0.35	0.79	disease	0.86	disease	0.76	disease	0.68	disease	4	1	deleterious	0.42	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	0.59	medium_impact	2.71	high_impact	0.08	0.8	NA	NA	0.57	P	0.97	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10210	10210	T	A	MI.15286	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	152	51	F	Y	tTc/tAc	3.83	1	0	probably_damaging	1	neutral	0.49	neutral	0.51	neutral	-2.71	deleterious	-2.92	medium_impact	2.95	0.74	neutral	0.36	neutral	4.21	23.90	deleterious	0.09	0.35	0.46	neutral	0.7	disease	0.61	disease	0.32	neutral	4	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.18	medium_impact	1.6	medium_impact	0.58	0.8	NA	NA	0.57	P	0.89	polymorphism	1	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10210	10210	T	G	MI.15287	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	152	51	F	C	tTc/tGc	3.83	1	0	probably_damaging	1	neutral	0.13	neutral	0.47	deleterious	-5.5	deleterious	-7.78	high_impact	4.5	0.7	neutral	0.08	damaging	4.11	23.80	deleterious	0.02	0.35	0.9	disease	0.85	disease	0.8	disease	0.67	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	-0.27	medium_impact	3.02	high_impact	0.11	0.8	NA	NA	0.64	P	0.99	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10211	10211	C	A	MI.15288	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	153	51	F	L	ttC/ttA	7.53	1	0.02	probably_damaging	1	neutral	0.59	neutral	0.64	neutral	-2.2	deleterious	-5.82	medium_impact	3.44	0.79	neutral	0.11	damaging	4.60	24.40	deleterious	0.05	0.35	0.5	disease	0.73	disease	0.72	disease	0.57	disease	1	1	deleterious	0.3	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.28	medium_impact	2.05	high_impact	0.61	0.8	NA	NA	0.54	P	0.91	polymorphism	1	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10211	10211	C	G	MI.15289	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	153	51	F	L	ttC/ttG	7.53	1	0.02	probably_damaging	1	neutral	0.59	neutral	0.64	neutral	-2.2	deleterious	-5.82	medium_impact	3.44	0.79	neutral	0.11	damaging	4.36	24.10	deleterious	0.05	0.35	0.5	disease	0.73	disease	0.72	disease	0.57	disease	1	1	deleterious	0.3	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.28	medium_impact	2.05	high_impact	0.61	0.8	NA	NA	0.54	P	0.91	polymorphism	1	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8405	8405	A	T	MI.1529	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	40	14	T	S	Acc/Tcc	-2.65	0	0	benign	0.03	neutral	0.17	neutral	1.99	neutral	-0.27	neutral	-1.33	low_impact	1.16	1	neutral	0.87	neutral	1.12	11.33	neutral	0.53760445	0.85	0.39	neutral	0.17	neutral	0.36	neutral	0.12	neutral	8	0.82	neutral	0.57	deleterious	-6	neutral	0.14	neutral	0.68	medium_impact	-0.1	medium_impact	-0.1	medium_impact	0.75	0.85	NA	NA	0.57	P	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10212	10212	T	G	MI.15290	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	154	52	S	A	Tcc/Gcc	-1.03	0.02	0	probably_damaging	1	neutral	0.79	neutral	0.76	neutral	-1.98	deleterious	-2.9	high_impact	4.21	0.55	damaging	0.12	damaging	3.64	23.20	deleterious	0.16	0.45	0.44	neutral	0.55	disease	0.7	disease	0.67	disease	3	1	deleterious	0.4	neutral	2	deleterious	0.75	deleterious	-3.43	low_impact	0.51	medium_impact	2.75	high_impact	0.33	0.8	2.61	6.64	0.33	N	0.50	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10212	10212	T	A	MI.15291	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	154	52	S	T	Tcc/Acc	-1.03	0.02	0	probably_damaging	1	neutral	0.6	neutral	0.79	neutral	-1.59	deleterious	-2.9	high_impact	3.6	0.51	damaging	0.13	damaging	3.73	23.30	deleterious	0.19	0.45	0.56	disease	0.64	disease	0.7	disease	0.65	disease	3	1	deleterious	0.3	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	0.29	medium_impact	2.19	high_impact	0.52	0.8	2.61	6.64	0.32	N	0.72	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10212	10212	T	C	MI.15292	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	154	52	S	P	Tcc/Ccc	-1.03	0.02	0	probably_damaging	1	neutral	0.34	neutral	0.72	neutral	-2.77	deleterious	-4.83	medium_impact	3.07	0.44	damaging	0.07	damaging	3.94	23.50	deleterious	0.05	0.35	0.74	disease	0.78	disease	0.68	disease	0.66	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.86	deleterious	-3.43	low_impact	0.03	medium_impact	1.71	medium_impact	0.17	0.8	2.61	6.64	0.41	N	0.98	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10213	10213	C	T	MI.15293	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	155	52	S	F	tCc/tTc	5.68	1	0	probably_damaging	1	neutral	0.23	neutral	0.69	deleterious	-4.6	deleterious	-5.83	high_impact	4.41	0.43	damaging	0.04	damaging	4.29	24.00	deleterious	0.05	0.35	0.83	disease	0.85	disease	0.72	disease	0.65	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	-0.1	medium_impact	2.94	high_impact	0.07	0.8	2.61	6.64	0.7	P	1.00	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10213	10213	C	A	MI.15294	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	155	52	S	Y	tCc/tAc	5.68	1	0	probably_damaging	1	neutral	0.16	neutral	0.69	deleterious	-4.22	deleterious	-5.83	high_impact	4.41	0.52	damaging	0.06	damaging	4.11	23.70	deleterious	0.05	0.35	0.85	disease	0.83	disease	0.72	disease	0.62	disease	2	1	deleterious	0.08	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	-0.21	medium_impact	2.94	high_impact	0.19	0.8	2.61	6.64	0.65	P	1.00	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10213	10213	C	G	MI.15295	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	155	52	S	C	tCc/tGc	5.68	1	0	probably_damaging	1	neutral	0.07	neutral	0.69	deleterious	-4.75	deleterious	-4.87	high_impact	3.95	0.5	damaging	0.06	damaging	3.58	23.20	deleterious	0.06	0.35	0.81	disease	0.75	disease	0.69	disease	0.64	disease	3	1	deleterious	0.04	neutral	2	deleterious	0.82	deleterious	-3.43	low_impact	-0.43	medium_impact	2.51	high_impact	0.26	0.8	2.61	6.64	0.62	P	1.00	polymorphism	1	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10215	10215	A	G	MI.15296	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	157	53	M	V	Ata/Gta	-8.66	0	0	probably_damaging	0.98	neutral	0.51	neutral	1.18	neutral	1.67	deleterious	-3.55	low_impact	0.86	0.91	neutral	0.66	neutral	2.76	21.20	deleterious	0.27	0.45	0.24	neutral	0.71	disease	0.65	disease	0.4	neutral	2	0.98	deleterious	0.27	neutral	-2	neutral	0.66	deleterious	-2.24	low_impact	0.2	medium_impact	-0.32	medium_impact	0.36	0.8	0.87	7.08	0.34	N	0.96	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10215	10215	A	C	MI.15297	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	157	53	M	L	Ata/Cta	-8.66	0	0	probably_damaging	0.96	neutral	0.66	neutral	1.19	neutral	1.73	neutral	-2.46	neutral_impact	0.68	0.83	neutral	0.85	neutral	1.65	14.15	neutral	0.27	0.45	0.09	neutral	0.32	neutral	0.52	disease	0.42	neutral	2	0.96	neutral	0.35	neutral	-2	neutral	0.61	deleterious	-1.96	low_impact	0.35	medium_impact	-0.49	medium_impact	0.30	0.8	0.87	7.08	0.31	N	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10215	10215	A	T	MI.15298	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	157	53	M	L	Ata/Tta	-8.66	0	0	probably_damaging	0.96	neutral	0.66	neutral	1.19	neutral	1.73	neutral	-2.46	neutral_impact	0.68	0.83	neutral	0.85	neutral	1.79	14.93	neutral	0.27	0.45	0.09	neutral	0.32	neutral	0.52	disease	0.42	neutral	2	0.96	neutral	0.35	neutral	-2	neutral	0.61	deleterious	-1.96	low_impact	0.35	medium_impact	-0.49	medium_impact	0.30	0.8	0.87	7.08	0.34	N	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10216	10216	T	A	MI.15299	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	158	53	M	K	aTa/aAa	2.21	0.96	0	probably_damaging	0.99	neutral	0.31	neutral	0.94	neutral	-1.68	deleterious	-5.59	high_impact	3.79	0.74	neutral	0.3	neutral	3.98	23.60	deleterious	0.02	0.35	0.7	disease	0.87	disease	0.8	disease	0.75	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-2.52	low_impact	0	medium_impact	2.37	high_impact	0.19	0.8	0.87	7.08	0.54	N	1.00	disease_causing	1	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8597	8597	T	C	MI.153	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	71	24	I	T	aTt/aCt	0.36	0.01	0.01	probably_damaging	0.99	neutral	0.53	neutral	3.91	deleterious	-3.91	deleterious	-3.73	low_impact	1.31	0.91	neutral	0.97	neutral	3.07	22.40	deleterious	0.49	0.65	0.45	neutral	0.22	neutral	0.36	neutral	0.37	neutral	3	0.99	deleterious	0.27	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	0.32	medium_impact	0.03	medium_impact	0.61	0.9	18.14	17.22	0.39	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8405	8405	A	G	MI.1530	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	40	14	T	A	Acc/Gcc	-2.65	0	0	benign	0	neutral	0.2	neutral	1.99	neutral	-0.13	neutral	-1.03	low_impact	1.5	0.99	neutral	0.78	neutral	0.00	2.61	deleterious	0.71418440	0.85	0.29	neutral	0.13	neutral	0.45	neutral	0.06	neutral	9	0.8	neutral	0.6	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	-0.05	medium_impact	0.19	medium_impact	0.54	0.85	NA	NA	0.53	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10216	10216	T	C	MI.15300	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	158	53	M	T	aTa/aCa	2.21	0.96	0	probably_damaging	0.99	neutral	0.4	neutral	0.99	neutral	-0.12	deleterious	-5.47	medium_impact	2.27	0.77	neutral	0.4	neutral	2.98	22.20	deleterious	0.12	0.4	0.52	disease	0.69	disease	0.75	disease	0.72	disease	4	0.99	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-2.52	low_impact	0.09	medium_impact	0.97	medium_impact	0.14	0.8	0.87	7.08	0.4	N	0.99	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10217	10217	A	T	MI.15301	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	159	53	M	I	atA/atT	5.68	1	0.01	probably_damaging	0.99	neutral	0.4	neutral	1.18	neutral	1.65	deleterious	-3.46	low_impact	1.17	0.78	neutral	0.61	neutral	2.21	17.56	deleterious	0.34	0.5	0.14	neutral	0.37	neutral	0.57	disease	0.43	neutral	1	0.99	deleterious	0.21	neutral	-2	neutral	0.65	deleterious	-2.52	low_impact	0.09	medium_impact	-0.04	medium_impact	0.51	0.8	0.87	7.08	0.55	P	0.96	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10217	10217	A	C	MI.15302	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	159	53	M	I	atA/atC	5.68	1	0.01	probably_damaging	0.99	neutral	0.4	neutral	1.18	neutral	1.65	deleterious	-3.46	low_impact	1.17	0.78	neutral	0.61	neutral	2.13	17.06	deleterious	0.34	0.5	0.14	neutral	0.37	neutral	0.57	disease	0.43	neutral	1	0.99	deleterious	0.21	neutral	-2	neutral	0.65	deleterious	-2.52	low_impact	0.09	medium_impact	-0.04	medium_impact	0.51	0.8	0.87	7.08	0.55	P	0.96	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10218	10218	A	C	MI.15303	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	160	54	K	Q	Aaa/Caa	-0.1	0.91	0	probably_damaging	1	neutral	0.32	neutral	0.99	neutral	-1.14	deleterious	-3.54	low_impact	1.64	0.68	neutral	0.16	damaging	3.43	23.00	deleterious	0.3	0.45	0.37	neutral	0.51	disease	0.4	neutral	0.21	neutral	6	1	deleterious	0.16	neutral	-2	neutral	0.75	deleterious	-3.43	low_impact	0.01	medium_impact	0.4	medium_impact	0.46	0.8	NA	NA	0.32	N	0.86	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10218	10218	A	G	MI.15304	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	160	54	K	E	Aaa/Gaa	-0.1	0.91	0	probably_damaging	1	neutral	0.27	neutral	0.95	neutral	-1.22	deleterious	-3.64	medium_impact	3.28	0.66	neutral	0.09	damaging	4.04	23.70	deleterious	0.13	0.4	0.43	neutral	0.8	disease	0.66	disease	0.73	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	-0.05	medium_impact	1.9	medium_impact	0.52	0.8	NA	NA	0.37	N	0.86	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10219	10219	A	T	MI.15305	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	161	54	K	M	aAa/aTa	4.99	1	0	probably_damaging	1	neutral	0.24	neutral	0.84	deleterious	-3.96	deleterious	-5.46	high_impact	3.97	0.7	neutral	0.09	damaging	3.85	23.40	deleterious	0.06	0.35	0.73	disease	0.64	disease	0.66	disease	0.7	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-3.43	low_impact	-0.09	medium_impact	2.53	high_impact	0.22	0.8	NA	NA	0.62	P	0.54	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10219	10219	A	C	MI.15306	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	161	54	K	T	aAa/aCa	4.99	1	0	probably_damaging	1	neutral	0.42	neutral	0.91	neutral	-2.07	deleterious	-5.44	high_impact	3.62	0.67	neutral	0.09	damaging	3.59	23.20	deleterious	0.06	0.35	0.52	disease	0.55	disease	0.64	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.43	low_impact	0.11	medium_impact	2.21	high_impact	0.26	0.8	NA	NA	0.58	P	0.81	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10220	10220	A	C	MI.15307	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	162	54	K	N	aaA/aaC	5.68	1	0	probably_damaging	1	neutral	0.32	neutral	0.91	neutral	-1.98	deleterious	-4.5	medium_impact	2.62	0.65	neutral	0.07	damaging	3.74	23.30	deleterious	0.4	0.5	0.5	disease	0.74	disease	0.66	disease	0.7	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.01	medium_impact	1.29	medium_impact	0.43	0.8	NA	NA	0.59	P	0.71	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10220	10220	A	T	MI.15308	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	162	54	K	N	aaA/aaT	5.68	1	0	probably_damaging	1	neutral	0.32	neutral	0.91	neutral	-1.98	deleterious	-4.5	medium_impact	2.62	0.65	neutral	0.07	damaging	3.81	23.40	deleterious	0.4	0.5	0.5	disease	0.74	disease	0.66	disease	0.7	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.01	medium_impact	1.29	medium_impact	0.43	0.8	NA	NA	0.6	P	0.71	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10221	10221	T	A	MI.15309	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	163	55	F	I	Ttc/Atc	0.59	0.99	0	probably_damaging	1	neutral	0.45	neutral	-0.05	deleterious	-6.44	deleterious	-5.77	high_impact	4.84	0.52	damaging	0.04	damaging	4.61	24.50	deleterious	0.05	0.35	0.67	disease	0.88	disease	0.73	disease	0.7	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	0.14	medium_impact	3.33	high_impact	0.26	0.8	1.74	6.59	0.66	P	0.95	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8406	8406	C	T	MI.1531	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	41	14	T	I	aCc/aTc	-13.98	0	0	benign	0.08	neutral	0.75	neutral	2.1	neutral	1.15	neutral	0.79	neutral_impact	0.36	1	neutral	0.94	neutral	-0.55	0.16	neutral	0.56663707	0.85	0.14	neutral	0.18	neutral	0.35	neutral	0.07	neutral	9	0.15	neutral	0.84	deleterious	-6	neutral	0.15	neutral	0.25	medium_impact	0.56	medium_impact	-0.79	medium_impact	0.71	0.85	NA	NA	0.31	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10221	10221	T	G	MI.15310	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	163	55	F	V	Ttc/Gtc	0.59	0.99	0	probably_damaging	1	neutral	0.47	neutral	-0.05	deleterious	-6.36	deleterious	-6.73	high_impact	4.84	0.51	damaging	0.04	damaging	4.17	23.80	deleterious	0.04	0.35	0.68	disease	0.9	disease	0.74	disease	0.71	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	0.16	medium_impact	3.33	high_impact	0.26	0.8	1.74	6.59	0.64	P	0.96	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10221	10221	T	C	MI.15311	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	163	55	F	L	Ttc/Ctc	0.59	0.99	0	probably_damaging	1	neutral	0.77	neutral	-0.01	deleterious	-4.91	deleterious	-5.77	high_impact	4.84	0.5	damaging	0.03	damaging	4.16	23.80	deleterious	0.04	0.35	0.5	disease	0.83	disease	0.71	disease	0.68	disease	4	1	deleterious	0.39	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.48	medium_impact	3.33	high_impact	0.39	0.8	1.74	6.59	0.66	P	0.91	polymorphism	1	0.83	.	.	.	.	.	MNGIE tissues	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10222	10222	T	A	MI.15312	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	164	55	F	Y	tTc/tAc	7.53	1	0	probably_damaging	1	neutral	0.88	neutral	0.43	neutral	-1.46	deleterious	-2.88	medium_impact	2.45	0.51	damaging	0.04	damaging	4.44	24.20	deleterious	0.09	0.35	0.46	neutral	0.83	disease	0.69	disease	0.67	disease	3	1	deleterious	0.44	neutral	1	deleterious	0.80	deleterious	-3.43	low_impact	0.67	medium_impact	1.14	medium_impact	0.47	0.8	1.74	6.59	0.57	P	0.89	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10222	10222	T	C	MI.15313	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	164	55	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	neutral	0.44	neutral	-0.05	deleterious	-6.87	deleterious	-7.67	high_impact	4.84	0.52	damaging	0.04	damaging	4.30	24.00	deleterious	0.01	0.35	0.79	disease	0.88	disease	0.72	disease	0.67	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	0.13	medium_impact	3.33	high_impact	0.25	0.8	1.74	6.59	0.63	P	0.97	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10222	10222	T	G	MI.15314	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	164	55	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	neutral	0.15	neutral	-0.06	deleterious	-8.39	deleterious	-7.71	high_impact	4.84	0.51	damaging	0.03	damaging	4.11	23.70	deleterious	0.02	0.35	0.9	disease	0.88	disease	0.76	disease	0.61	disease	2	1	deleterious	0.08	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.23	medium_impact	3.33	high_impact	0.22	0.8	1.74	6.59	0.6	P	0.99	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10223	10223	C	A	MI.15315	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	165	55	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	neutral	0.77	neutral	-0.01	deleterious	-4.91	deleterious	-5.77	high_impact	4.84	0.5	damaging	0.03	damaging	4.63	24.50	deleterious	0.04	0.35	0.5	disease	0.83	disease	0.71	disease	0.68	disease	4	1	deleterious	0.39	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.48	medium_impact	3.33	high_impact	0.39	0.8	1.74	6.59	0.7	P	0.91	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10223	10223	C	G	MI.15316	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	165	55	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	neutral	0.77	neutral	-0.01	deleterious	-4.91	deleterious	-5.77	high_impact	4.84	0.5	damaging	0.03	damaging	4.35	24.10	deleterious	0.04	0.35	0.5	disease	0.83	disease	0.71	disease	0.68	disease	4	1	deleterious	0.39	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.48	medium_impact	3.33	high_impact	0.39	0.8	1.74	6.59	0.7	P	0.91	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10224	10224	T	A	MI.15317	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	166	56	F	I	Ttc/Atc	-4.96	0	0	probably_damaging	1	neutral	0.18	neutral	0.38	neutral	-2.8	deleterious	-5.76	medium_impact	3.35	0.6	damaging	0.12	damaging	4.31	24.00	deleterious	0.07	0.35	0.67	disease	0.89	disease	0.73	disease	0.7	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	-0.18	medium_impact	1.96	medium_impact	0.44	0.8	NA	NA	0.37	N	0.95	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10224	10224	T	C	MI.15318	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	166	56	F	L	Ttc/Ctc	-4.96	0	0	probably_damaging	1	neutral	0.32	neutral	0.42	neutral	-1.96	deleterious	-5.76	high_impact	4.12	0.57	damaging	0.11	damaging	3.99	23.60	deleterious	0.05	0.35	0.5	disease	0.85	disease	0.7	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.43	low_impact	0.01	medium_impact	2.67	high_impact	0.54	0.8	NA	NA	0.42	N	0.91	polymorphism	1	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10224	10224	T	G	MI.15319	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	166	56	F	V	Ttc/Gtc	-4.96	0	0	probably_damaging	1	neutral	0.15	neutral	0.37	neutral	-2.83	deleterious	-6.72	high_impact	4.32	0.52	damaging	0.09	damaging	4.01	23.60	deleterious	0.05	0.35	0.68	disease	0.91	disease	0.73	disease	0.71	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-3.43	low_impact	-0.23	medium_impact	2.85	high_impact	0.29	0.8	NA	NA	0.42	N	0.96	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8406	8406	C	A	MI.1532	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	41	14	T	N	aCc/aAc	-13.98	0	0	benign	0.14	neutral	0.08	neutral	1.93	neutral	-2.68	neutral	-2.41	medium_impact	2.2	0.99	neutral	0.61	neutral	1.57	13.68	neutral	0.48904297	0.85	0.55	disease	0.3	neutral	0.57	disease	0.22	neutral	6	0.91	neutral	0.47	deleterious	-3	neutral	0.25	neutral	-0.01	medium_impact	-0.31	medium_impact	0.79	medium_impact	0.80	0.85	NA	NA	0.49	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10225	10225	T	C	MI.15320	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	167	56	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	neutral	0.13	neutral	0.38	deleterious	-3.66	deleterious	-7.66	high_impact	3.97	0.6	neutral	0.12	damaging	4.22	23.90	deleterious	0.02	0.35	0.79	disease	0.89	disease	0.71	disease	0.67	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	-0.27	medium_impact	2.53	high_impact	0.15	0.8	NA	NA	0.66	P	0.97	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10225	10225	T	G	MI.15321	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	167	56	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	neutral	0.05	neutral	0.35	deleterious	-4.9	deleterious	-7.71	high_impact	3.77	0.58	damaging	0.09	damaging	4.10	23.70	deleterious	0.03	0.35	0.9	disease	0.9	disease	0.75	disease	0.61	disease	2	1	deleterious	0.03	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.52	medium_impact	2.35	high_impact	0.15	0.8	NA	NA	0.62	P	0.99	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10225	10225	T	A	MI.15322	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	167	56	F	Y	tTc/tAc	7.53	1	0	probably_damaging	1	neutral	0.14	neutral	1.05	neutral	2.91	deleterious	-2.88	low_impact	1.9	0.6	damaging	0.09	damaging	4.23	23.90	deleterious	0.09	0.4	0.46	neutral	0.84	disease	0.68	disease	0.69	disease	4	1	deleterious	0.07	neutral	-2	neutral	0.79	deleterious	-3.43	low_impact	-0.25	medium_impact	0.63	medium_impact	0.51	0.8	NA	NA	0.57	P	0.89	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10226	10226	C	A	MI.15323	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	168	56	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	neutral	0.32	neutral	0.42	neutral	-1.96	deleterious	-5.76	high_impact	4.12	0.57	damaging	0.11	damaging	4.67	24.50	deleterious	0.05	0.35	0.5	disease	0.85	disease	0.7	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.43	low_impact	0.01	medium_impact	2.67	high_impact	0.54	0.8	NA	NA	0.65	P	0.91	polymorphism	1	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10226	10226	C	G	MI.15324	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	168	56	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	neutral	0.32	neutral	0.42	neutral	-1.96	deleterious	-5.76	high_impact	4.12	0.57	damaging	0.11	damaging	4.37	24.10	deleterious	0.05	0.35	0.5	disease	0.85	disease	0.7	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.43	low_impact	0.01	medium_impact	2.67	high_impact	0.54	0.8	NA	NA	0.65	P	0.91	polymorphism	1	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10227	10227	T	A	MI.15325	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	169	57	L	M	Tta/Ata	-1.95	0	0	probably_damaging	1	neutral	0.09	neutral	0.67	neutral	-2.34	neutral	-1.92	medium_impact	2.89	0.61	neutral	0.17	damaging	3.48	23.10	deleterious	0.16	0.45	0.59	disease	0.56	disease	0.58	disease	0.49	neutral	0	1	deleterious	0.05	neutral	1	deleterious	0.75	deleterious	-3.43	low_impact	-0.37	medium_impact	1.54	medium_impact	0.47	0.8	NA	NA	0.34	N	0.91	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10227	10227	T	G	MI.15326	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	169	57	L	V	Tta/Gta	-1.95	0	0	probably_damaging	1	neutral	0.24	neutral	0.76	neutral	-1.5	deleterious	-2.88	medium_impact	3.17	0.43	damaging	0.06	damaging	3.37	22.90	deleterious	0.14	0.4	0.51	disease	0.68	disease	0.61	disease	0.63	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-3.43	low_impact	-0.09	medium_impact	1.8	medium_impact	0.46	0.8	NA	NA	0.43	N	0.89	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10228	10228	T	G	MI.15327	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	170	57	L	W	tTa/tGa	-0.57	0	0	probably_damaging	1	deleterious	0.04	neutral	0.6	deleterious	-5.97	deleterious	-5.79	high_impact	4.82	0.53	damaging	0.05	damaging	3.75	23.30	deleterious	0.04	0.35	0.91	disease	0.76	disease	0.68	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.43	low_impact	-0.58	medium_impact	3.31	high_impact	0.22	0.8	NA	NA	0.54	P	0.98	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10228	10228	T	C	MI.15328	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	170	57	L	S	tTa/tCa	-0.57	0	0	probably_damaging	1	neutral	0.28	neutral	0.66	deleterious	-3.74	deleterious	-5.74	high_impact	4.26	0.51	damaging	0.06	damaging	3.75	23.30	deleterious	0.04	0.35	0.8	disease	0.78	disease	0.64	disease	0.65	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.04	medium_impact	2.8	high_impact	0.31	0.8	NA	NA	0.36	N	0.97	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10229	10229	A	C	MI.15329	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	171	57	L	F	ttA/ttC	7.53	0.96	0	probably_damaging	1	neutral	1	neutral	0.66	deleterious	-3.54	deleterious	-3.84	medium_impact	3.5	0.46	damaging	0.05	damaging	3.45	23.00	deleterious	0.12	0.4	0.62	disease	0.74	disease	0.66	disease	0.66	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.81	deleterious	-3.43	low_impact	1.85	high_impact	2.1	high_impact	0.48	0.8	NA	NA	0.52	N	0.99	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8406	8406	C	G	MI.1533	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	41	14	T	S	aCc/aGc	-13.98	0	0	benign	0.03	neutral	0.17	neutral	1.99	neutral	-0.27	neutral	-1.33	low_impact	1.16	1	neutral	0.87	neutral	1.36	12.57	neutral	0.53760445	0.85	0.39	neutral	0.17	neutral	0.36	neutral	0.12	neutral	8	0.82	neutral	0.57	deleterious	-6	neutral	0.14	neutral	0.68	medium_impact	-0.1	medium_impact	-0.1	medium_impact	0.75	0.85	NA	NA	0.54	P	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10229	10229	A	T	MI.15330	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	171	57	L	F	ttA/ttT	7.53	0.96	0	probably_damaging	1	neutral	1	neutral	0.66	deleterious	-3.54	deleterious	-3.84	medium_impact	3.5	0.46	damaging	0.05	damaging	3.58	23.20	deleterious	0.12	0.4	0.62	disease	0.74	disease	0.66	disease	0.66	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.81	deleterious	-3.43	low_impact	1.85	high_impact	2.1	high_impact	0.48	0.8	NA	NA	0.53	N	0.99	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10230	10230	G	A	MI.15331	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	172	58	V	M	Gta/Ata	-0.33	0	0	probably_damaging	0.95	neutral	0.05	neutral	0.74	neutral	-2.37	deleterious	-2.68	medium_impact	3.37	0.68	neutral	0.5	neutral	3.62	23.20	deleterious	0.09	0.35	0.59	disease	0.74	disease	0.65	disease	0.65	disease	3	0.99	deleterious	0.05	neutral	1	deleterious	0.72	deleterious	-1.87	low_impact	-0.52	medium_impact	1.98	medium_impact	0.93	0.95	0.87	6.79	0.39	N	0.70	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10230	10230	G	C	MI.15332	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	172	58	V	L	Gta/Cta	-0.33	0	0	possibly_damaging	0.49	neutral	0.9	neutral	0.94	neutral	-0.28	neutral	-2.46	low_impact	1.9	0.69	neutral	0.49	neutral	1.93	15.75	deleterious	0.17	0.45	0.31	neutral	0.76	disease	0.55	disease	0.26	neutral	5	0.42	neutral	0.71	deleterious	-3	neutral	0.55	deleterious	-0.7	medium_impact	0.72	medium_impact	0.63	medium_impact	0.35	0.8	0.87	6.79	0.26	N	0.66	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10230	10230	G	T	MI.15333	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	172	58	V	L	Gta/Tta	-0.33	0	0	possibly_damaging	0.49	neutral	0.9	neutral	0.94	neutral	-0.28	neutral	-2.46	low_impact	1.9	0.69	neutral	0.49	neutral	2.09	16.78	deleterious	0.17	0.45	0.31	neutral	0.76	disease	0.55	disease	0.26	neutral	5	0.42	neutral	0.71	deleterious	-3	neutral	0.55	deleterious	-0.7	medium_impact	0.72	medium_impact	0.63	medium_impact	0.35	0.8	0.87	6.79	0.27	N	0.66	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10231	10231	T	G	MI.15334	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	173	58	V	G	gTa/gGa	1.52	0.95	0	possibly_damaging	0.82	neutral	0.11	neutral	0.69	deleterious	-4.12	deleterious	-6.75	high_impact	4.41	0.66	neutral	0.51	neutral	2.24	17.76	deleterious	0.03	0.35	0.81	disease	0.85	disease	0.64	disease	0.66	disease	3	0.94	neutral	0.15	neutral	1	deleterious	0.72	deleterious	-1.31	low_impact	-0.31	medium_impact	2.94	high_impact	0.24	0.8	0.87	6.79	0.59	P	0.95	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10231	10231	T	A	MI.15335	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	173	58	V	E	gTa/gAa	1.52	0.95	0	probably_damaging	0.94	neutral	0.06	neutral	0.69	deleterious	-4.28	deleterious	-5.79	high_impact	4.41	0.69	neutral	0.38	neutral	4.74	24.70	deleterious	0.03	0.35	0.82	disease	0.88	disease	0.75	disease	0.69	disease	4	0.99	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-1.8	low_impact	-0.47	medium_impact	2.94	high_impact	0.20	0.8	0.87	6.79	0.6	P	0.98	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10231	10231	T	C	MI.15336	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	173	58	V	A	gTa/gCa	1.52	0.95	0	benign	0.08	neutral	0.28	neutral	0.74	neutral	-2.31	deleterious	-3.83	high_impact	4.05	0.71	neutral	0.55	neutral	1.64	14.07	neutral	0.07	0.35	0.52	disease	0.63	disease	0.62	disease	0.63	disease	3	0.69	neutral	0.6	deleterious	-2	neutral	0.24	neutral	0.24	medium_impact	-0.04	medium_impact	2.61	high_impact	0.17	0.8	0.87	6.79	0.54	P	0.75	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10233	10233	G	T	MI.15337	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	175	59	A	S	Gct/Tct	-4.04	0	0	probably_damaging	1	neutral	0.23	neutral	0.8	deleterious	-3.64	deleterious	-2.75	medium_impact	2.62	0.55	damaging	0.06	damaging	3.68	23.30	deleterious	0.11	0.4	0.39	neutral	0.8	disease	0.65	disease	0.66	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	-0.1	medium_impact	1.29	medium_impact	0.55	0.8	2.61	7.03	0.29	N	0.98	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10233	10233	G	C	MI.15338	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	175	59	A	P	Gct/Cct	-4.04	0	0	probably_damaging	1	deleterious	0.04	neutral	0.67	deleterious	-6.1	deleterious	-4.71	high_impact	4.2	0.48	damaging	0.04	damaging	3.79	23.40	deleterious	0.02	0.35	0.67	disease	0.86	disease	0.77	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-3.43	low_impact	-0.58	medium_impact	2.74	high_impact	0.48	0.8	2.61	7.03	0.41	N	0.96	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10233	10233	G	A	MI.15339	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	175	59	A	T	Gct/Act	-4.04	0	0	probably_damaging	1	neutral	0.15	neutral	0.74	deleterious	-4.39	deleterious	-3.75	medium_impact	2.95	0.47	damaging	0.06	damaging	4.20	23.90	deleterious	0.07	0.35	0.29	neutral	0.75	disease	0.63	disease	0.55	disease	1	1	deleterious	0.08	neutral	1	deleterious	0.77	deleterious	-3.43	low_impact	-0.23	medium_impact	1.6	medium_impact	0.72	0.85	2.61	7.03	0.37	N	0.93	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8408	8408	C	A	MI.1534	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	43	15	P	T	Ccc/Acc	-5.66	0	0	probably_damaging	1	neutral	0.21	neutral	2.06	neutral	1.47	neutral	0.62	neutral_impact	-0.34	0.97	neutral	0.9	neutral	0.79	9.41	deleterious	0.48647755	0.85	0.36	neutral	0.07	neutral	0.35	neutral	0.04	neutral	9	1	deleterious	0.11	neutral	-2	neutral	0.66	deleterious	-3.6	low_impact	-0.03	medium_impact	-1.39	low_impact	0.77	0.85	8.82	7.31	0.56	P	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10234	10234	C	T	MI.15340	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	176	59	A	V	gCt/gTt	9.15	1	0	probably_damaging	1	neutral	0.9	neutral	0.83	deleterious	-5.38	deleterious	-3.81	medium_impact	3.3	0.42	damaging	0.05	damaging	4.36	24.10	deleterious	0.05	0.35	0.53	disease	0.84	disease	0.66	disease	0.69	disease	4	1	deleterious	0.45	neutral	1	deleterious	0.80	deleterious	-3.43	low_impact	0.72	medium_impact	1.92	medium_impact	0.66	0.8	2.61	7.03	0.65	P	0.79	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10234	10234	C	A	MI.15341	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	176	59	A	D	gCt/gAt	9.15	1	0	probably_damaging	1	deleterious	0.04	neutral	0.68	deleterious	-6.18	deleterious	-5.57	high_impact	4.75	0.57	damaging	0.04	damaging	4.55	24.40	deleterious	0.02	0.35	0.7	disease	0.9	disease	0.77	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.43	low_impact	-0.58	medium_impact	3.25	high_impact	0.35	0.8	2.61	7.03	0.69	P	0.96	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10234	10234	C	G	MI.15342	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	176	59	A	G	gCt/gGt	9.15	1	0	probably_damaging	1	neutral	0.11	neutral	0.71	deleterious	-4.12	deleterious	-3.46	medium_impact	2.18	0.54	damaging	0.62	neutral	2.84	21.60	deleterious	0.09	0.35	0.5	disease	0.76	disease	0.62	disease	0.34	neutral	3	1	deleterious	0.06	neutral	1	deleterious	0.77	deleterious	-3.43	low_impact	-0.31	medium_impact	0.89	medium_impact	0.66	0.8	2.61	7.03	0.58	P	0.85	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10236	10236	A	G	MI.15343	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	178	60	I	V	Att/Gtt	-8.89	0	0	possibly_damaging	0.64	neutral	0.22	neutral	0.96	neutral	-1.31	neutral	-0.95	low_impact	1.92	0.58	damaging	0.43	neutral	3.01	22.30	deleterious	0.35	0.5	0.19	neutral	0.37	neutral	0.43	neutral	0.39	neutral	2	0.8	neutral	0.29	neutral	-3	neutral	0.50	deleterious	-0.94	medium_impact	-0.12	medium_impact	0.65	medium_impact	0.61	0.8	1.74	7.14	0.47	N	0.79	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10236	10236	A	T	MI.15344	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	178	60	I	F	Att/Ttt	-8.89	0	0	probably_damaging	0.92	neutral	0.58	neutral	0.72	neutral	-2.82	deleterious	-3.74	high_impact	4.31	0.53	damaging	0.33	neutral	4.00	23.60	deleterious	0.08	0.35	0.62	disease	0.83	disease	0.65	disease	0.67	disease	3	0.91	neutral	0.33	neutral	2	deleterious	0.79	deleterious	-1.68	low_impact	0.27	medium_impact	2.84	high_impact	0.62	0.8	1.74	7.14	0.4	N	0.97	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10236	10236	A	C	MI.15345	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	178	60	I	L	Att/Ctt	-8.89	0	0	benign	0.12	neutral	0.54	neutral	1.08	neutral	0.78	neutral	-1.77	medium_impact	2.32	0.5	damaging	0.37	neutral	3.74	23.30	deleterious	0.22	0.45	0.29	neutral	0.72	disease	0.51	disease	0.53	disease	1	0.37	neutral	0.71	deleterious	-3	neutral	0.23	neutral	0.06	medium_impact	0.23	medium_impact	1.02	medium_impact	0.62	0.8	1.74	7.14	0.38	N	0.85	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10237	10237	T	A	MI.15346	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	179	60	I	N	aTt/aAt	4.76	1	0	probably_damaging	0.99	deleterious	0.03	neutral	0.68	deleterious	-5.01	deleterious	-6.62	high_impact	3.96	0.5	damaging	0.31	neutral	4.37	24.10	deleterious	0.06	0.35	0.82	disease	0.86	disease	0.64	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-2.52	low_impact	-0.65	medium_impact	2.52	high_impact	0.34	0.8	1.74	7.14	0.57	P	0.99	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10237	10237	T	G	MI.15347	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	179	60	I	S	aTt/aGt	4.76	1	0	probably_damaging	0.97	deleterious	0.04	neutral	0.7	deleterious	-3.86	deleterious	-5.64	high_impact	4.66	0.55	damaging	0.38	neutral	4.25	23.90	deleterious	0.03	0.35	0.71	disease	0.84	disease	0.61	disease	0.67	disease	3	0.99	deleterious	0.04	neutral	6	deleterious	0.81	deleterious	-2.08	low_impact	-0.58	medium_impact	3.16	high_impact	0.28	0.8	1.74	7.14	0.64	P	0.96	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10237	10237	T	C	MI.15348	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	179	60	I	T	aTt/aCt	4.76	1	0	probably_damaging	0.96	neutral	0.09	neutral	0.71	deleterious	-3.14	deleterious	-4.68	high_impact	3.86	0.43	damaging	0.37	neutral	3.33	22.90	deleterious	0.06	0.35	0.53	disease	0.7	disease	0.59	disease	0.64	disease	3	0.98	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-1.96	low_impact	-0.37	medium_impact	2.43	high_impact	0.28	0.8	1.74	7.14	0.79	P	0.99	disease_causing_automatic	0	0.74	rs193302927	Pathogenic	Leber's_optic_atrophy	76416	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	CPD	0.15	T10237C	LHON	+	-	Reported	1	P	P	P	damaging
chrM	10238	10238	T	A	MI.15349	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	180	60	I	M	atT/atA	7.53	1	0.08	probably_damaging	0.97	neutral	0.17	neutral	0.77	neutral	-0.35	deleterious	-2.76	medium_impact	2.66	0.57	damaging	0.38	neutral	3.68	23.30	deleterious	0.19	0.45	0.54	disease	0.66	disease	0.56	disease	0.5	neutral	0	0.98	deleterious	0.1	neutral	1	deleterious	0.72	deleterious	-2.08	low_impact	-0.19	medium_impact	1.33	medium_impact	0.54	0.8	1.74	7.14	0.66	P	0.78	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8408	8408	C	T	MI.1535	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	43	15	P	S	Ccc/Tcc	-5.66	0	0	probably_damaging	1	neutral	0.62	neutral	2.2	neutral	2.94	neutral	2.01	neutral_impact	-2.1	1	neutral	0.97	neutral	1.03	10.83	neutral	0.60673599	0.85	0.11	neutral	0.04	neutral	0.4	neutral	0.04	neutral	9	0.99	deleterious	0.31	neutral	-2	neutral	0.62	deleterious	-3.6	low_impact	0.41	medium_impact	-2.9	low_impact	0.46	0.85	8.82	7.31	0.4	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10238	10238	T	G	MI.15350	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	180	60	I	M	atT/atG	7.53	1	0.08	probably_damaging	0.97	neutral	0.17	neutral	0.77	neutral	-0.35	deleterious	-2.76	medium_impact	2.66	0.57	damaging	0.38	neutral	3.39	23.00	deleterious	0.19	0.45	0.54	disease	0.66	disease	0.56	disease	0.5	neutral	0	0.98	deleterious	0.1	neutral	1	deleterious	0.72	deleterious	-2.08	low_impact	-0.19	medium_impact	1.33	medium_impact	0.54	0.8	1.74	7.14	0.66	P	0.78	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10239	10239	A	C	MI.15351	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	181	61	T	P	Acc/Ccc	-2.19	0	0	benign	0.19	deleterious	0.02	neutral	0.94	neutral	-2.19	deleterious	-4.92	medium_impact	2.81	0.57	damaging	0.05	damaging	2.30	18.16	deleterious	0.05	0.35	0.6	disease	0.92	disease	0.65	disease	0.75	disease	5	0.98	neutral	0.42	neutral	1	deleterious	0.43	neutral	-0.15	medium_impact	-0.75	medium_impact	1.47	medium_impact	0.27	0.8	2.61	6.75	0.25	N	0.98	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10239	10239	A	T	MI.15352	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	181	61	T	S	Acc/Tcc	-2.19	0	0	probably_damaging	0.94	neutral	0.07	neutral	0.99	neutral	-0.25	deleterious	-3.39	medium_impact	2.46	0.78	neutral	0.11	damaging	1.44	13.00	neutral	0.3	0.45	0.38	neutral	0.63	disease	0.52	disease	0.57	disease	1	0.98	deleterious	0.07	neutral	1	deleterious	0.70	deleterious	-1.8	low_impact	-0.43	medium_impact	1.15	medium_impact	0.36	0.8	2.61	6.75	0.34	N	0.89	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10239	10239	A	G	MI.15353	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	181	61	T	A	Acc/Gcc	-2.19	0	0	possibly_damaging	0.87	neutral	0.37	neutral	1.01	neutral	0.18	deleterious	-4.12	medium_impact	2.56	0.71	neutral	0.11	damaging	2.15	17.18	deleterious	0.22	0.45	0.28	neutral	0.56	disease	0.52	disease	0.56	disease	1	0.87	neutral	0.25	neutral	0	NA	0.66	deleterious	-1.46	low_impact	0.06	medium_impact	1.24	medium_impact	0.26	0.8	2.61	6.75	0.31	N	0.72	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10240	10240	C	T	MI.15354	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	182	61	T	I	aCc/aTc	1.29	0.45	0	probably_damaging	0.99	neutral	1	neutral	1.16	neutral	1.78	deleterious	-4.73	neutral_impact	0.42	0.69	neutral	0.1	damaging	2.67	20.60	deleterious	0.13	0.4	0.12	neutral	0.71	disease	0.34	neutral	0.21	neutral	6	0.99	deleterious	0.51	deleterious	-2	neutral	0.68	deleterious	-2.52	low_impact	1.85	high_impact	-0.72	medium_impact	0.46	0.8	2.61	6.75	0.23	N	0.96	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10240	10240	C	G	MI.15355	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	182	61	T	S	aCc/aGc	1.29	0.45	0	probably_damaging	0.94	neutral	0.07	neutral	0.99	neutral	-0.25	deleterious	-3.39	medium_impact	2.46	0.78	neutral	0.11	damaging	1.66	14.16	neutral	0.3	0.45	0.38	neutral	0.63	disease	0.52	disease	0.57	disease	1	0.98	deleterious	0.07	neutral	1	deleterious	0.70	deleterious	-1.8	low_impact	-0.43	medium_impact	1.15	medium_impact	0.36	0.8	2.61	6.75	0.31	N	0.89	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10240	10240	C	A	MI.15356	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	182	61	T	N	aCc/aAc	1.29	0.45	0	probably_damaging	0.98	deleterious	0.02	neutral	0.95	neutral	-1.88	deleterious	-4.37	medium_impact	3.36	0.66	neutral	0.08	damaging	2.48	19.36	deleterious	0.3	0.45	0.53	disease	0.83	disease	0.55	disease	0.72	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-2.24	low_impact	-0.75	medium_impact	1.97	medium_impact	0.40	0.8	2.61	6.75	0.31	N	0.94	polymorphism	1	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10242	10242	T	G	MI.15357	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	184	62	F	V	Ttc/Gtc	-3.34	0	0	probably_damaging	1	neutral	0.29	neutral	-0.47	deleterious	-6.43	deleterious	-6.54	high_impact	4.93	0.51	damaging	0.04	damaging	4.11	23.80	deleterious	0.07	0.35	0.67	disease	0.91	disease	0.7	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	-0.03	medium_impact	3.41	high_impact	0.24	0.8	1.74	6.65	0.54	P	0.96	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10242	10242	T	A	MI.15358	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	184	62	F	I	Ttc/Atc	-3.34	0	0	probably_damaging	1	neutral	0.46	neutral	-0.47	deleterious	-6.38	deleterious	-5.6	high_impact	4.12	0.52	damaging	0.04	damaging	4.42	24.20	deleterious	0.06	0.35	0.66	disease	0.9	disease	0.71	disease	0.71	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.82	deleterious	-3.43	low_impact	0.15	medium_impact	2.67	high_impact	0.31	0.8	1.74	6.65	0.38	N	0.95	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10242	10242	T	C	MI.15359	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	184	62	F	L	Ttc/Ctc	-3.34	0	0	probably_damaging	1	neutral	1	neutral	-0.4	deleterious	-4.59	deleterious	-5.6	high_impact	4.24	0.5	damaging	0.03	damaging	4.08	23.70	deleterious	0.06	0.35	0.5	neutral	0.88	disease	0.68	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.79	deleterious	-3.43	low_impact	1.85	high_impact	2.78	high_impact	0.35	0.8	1.74	6.65	0.39	N	0.91	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8408	8408	C	G	MI.1536	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	43	15	P	A	Ccc/Gcc	-5.66	0	0	probably_damaging	0.99	neutral	0.26	neutral	2.06	neutral	1.62	neutral	0.31	neutral_impact	-0.06	0.99	neutral	0.91	neutral	1.03	10.80	neutral	0.41328743	0.85	0.26	neutral	0.05	neutral	0.36	neutral	0.04	neutral	9	0.99	deleterious	0.14	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	0.04	medium_impact	-1.15	low_impact	0.76	0.85	8.82	7.31	0.6	P	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10243	10243	T	C	MI.15360	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	185	62	F	S	tTc/tCc	5.68	1	0	probably_damaging	1	deleterious	0.04	neutral	-0.49	deleterious	-7.45	deleterious	-7.46	high_impact	4.58	0.52	damaging	0.04	damaging	4.23	23.90	deleterious	0.03	0.35	0.78	disease	0.89	disease	0.69	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.43	low_impact	-0.58	medium_impact	3.09	high_impact	0.13	0.8	1.74	6.65	0.56	P	0.97	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10243	10243	T	A	MI.15361	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	185	62	F	Y	tTc/tAc	5.68	1	0	probably_damaging	1	neutral	0.06	neutral	-0.34	deleterious	-3.9	deleterious	-2.8	high_impact	3.77	0.51	damaging	0.04	damaging	4.22	23.90	deleterious	0.09	0.4	0.45	neutral	0.85	disease	0.7	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	-0.47	medium_impact	2.35	high_impact	0.50	0.8	1.74	6.65	0.62	P	0.89	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10243	10243	T	G	MI.15362	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	185	62	F	C	tTc/tGc	5.68	1	0	probably_damaging	1	deleterious	0.01	neutral	-0.5	deleterious	-8.88	deleterious	-7.48	high_impact	4.93	0.51	damaging	0.03	damaging	4.12	23.80	deleterious	0.04	0.35	0.9	disease	0.9	disease	0.74	disease	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.43	low_impact	-0.92	medium_impact	3.41	high_impact	0.12	0.8	1.74	6.65	0.58	P	0.99	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10244	10244	C	A	MI.15363	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	186	62	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	neutral	1	neutral	-0.4	deleterious	-4.59	deleterious	-5.6	high_impact	4.24	0.5	damaging	0.03	damaging	4.69	24.60	deleterious	0.06	0.35	0.5	neutral	0.88	disease	0.68	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.79	deleterious	-3.43	low_impact	1.85	high_impact	2.78	high_impact	0.35	0.8	1.74	6.65	0.58	P	0.91	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10244	10244	C	G	MI.15364	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	186	62	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	neutral	1	neutral	-0.4	deleterious	-4.59	deleterious	-5.6	high_impact	4.24	0.5	damaging	0.03	damaging	4.39	24.10	deleterious	0.06	0.35	0.5	neutral	0.88	disease	0.68	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.79	deleterious	-3.43	low_impact	1.85	high_impact	2.78	high_impact	0.35	0.8	1.74	6.65	0.58	P	0.91	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10245	10245	T	G	MI.15365	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	187	63	L	V	Tta/Gta	-3.34	0	0	probably_damaging	0.92	neutral	0.38	neutral	1	neutral	0.03	deleterious	-2.88	medium_impact	2.52	0.43	damaging	0.28	neutral	3.12	22.60	deleterious	0.17	0.45	0.44	neutral	0.66	disease	0.63	disease	0.65	disease	3	0.92	neutral	0.23	neutral	1	deleterious	0.74	deleterious	-1.68	low_impact	0.07	medium_impact	1.2	medium_impact	0.40	0.8	2.61	6.7	0.45	N	0.89	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10245	10245	T	A	MI.15366	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	187	63	L	M	Tta/Ata	-3.34	0	0	probably_damaging	0.98	neutral	0.16	neutral	0.68	deleterious	-3.06	neutral	-1.93	medium_impact	3.34	0.57	damaging	0.43	neutral	3.45	23.00	deleterious	0.12	0.4	0.56	disease	0.63	disease	0.58	disease	0.62	disease	2	0.99	deleterious	0.09	neutral	1	deleterious	0.74	deleterious	-2.24	low_impact	-0.21	medium_impact	1.95	medium_impact	0.34	0.8	2.61	6.7	0.4	N	0.91	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10246	10246	T	G	MI.15367	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	188	63	L	W	tTa/tGa	-0.33	0	0	probably_damaging	1	deleterious	0.01	neutral	0.61	deleterious	-6.61	deleterious	-5.74	high_impact	4.72	0.51	damaging	0.26	damaging	3.77	23.40	deleterious	0.04	0.35	0.88	disease	0.81	disease	0.68	disease	0.64	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.43	low_impact	-0.92	medium_impact	3.22	high_impact	0.20	0.8	2.61	6.7	0.55	P	0.98	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10246	10246	T	C	MI.15368	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	188	63	L	S	tTa/tCa	-0.33	0	0	probably_damaging	0.91	neutral	0.12	neutral	0.64	deleterious	-4.55	deleterious	-5.71	high_impact	4.38	0.49	damaging	0.33	neutral	3.55	23.10	deleterious	0.04	0.35	0.63	disease	0.78	disease	0.66	disease	0.66	disease	3	0.96	neutral	0.11	neutral	2	deleterious	0.79	deleterious	-1.62	low_impact	-0.29	medium_impact	2.91	high_impact	0.22	0.8	2.61	6.7	0.48	N	0.97	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10247	10247	A	C	MI.15369	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	189	63	L	F	ttA/ttC	4.52	0.69	0	probably_damaging	0.98	neutral	1	neutral	0.65	deleterious	-3.65	deleterious	-3.85	high_impact	4.17	0.54	damaging	0.34	neutral	3.44	23.00	deleterious	0.12	0.4	0.58	disease	0.76	disease	0.66	disease	0.65	disease	3	0.98	deleterious	0.51	deleterious	2	deleterious	0.80	deleterious	-2.24	low_impact	1.85	high_impact	2.72	high_impact	0.33	0.8	2.61	6.7	0.46	N	0.99	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8409	8409	C	T	MI.1537	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	44	15	P	L	cCc/cTc	-1.26	0	0	probably_damaging	1	neutral	0.86	neutral	2.2	neutral	2.95	neutral	-2.07	neutral_impact	-0.52	1	neutral	0.67	neutral	3.08	22.50	deleterious	0.60355318	0.85	0.56	disease	0.2	neutral	0.36	neutral	0.12	neutral	8	1	deleterious	0.43	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.74	medium_impact	-1.54	low_impact	0.74	0.85	8.82	7.31	0.33	N	0.17	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10247	10247	A	T	MI.15370	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	189	63	L	F	ttA/ttT	4.52	0.69	0	probably_damaging	0.98	neutral	1	neutral	0.65	deleterious	-3.65	deleterious	-3.85	high_impact	4.17	0.54	damaging	0.34	neutral	3.51	23.10	deleterious	0.12	0.4	0.58	disease	0.76	disease	0.66	disease	0.65	disease	3	0.98	deleterious	0.51	deleterious	2	deleterious	0.80	deleterious	-2.24	low_impact	1.85	high_impact	2.72	high_impact	0.33	0.8	2.61	6.7	0.47	N	0.99	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10248	10248	T	G	MI.15371	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	190	64	L	V	Tta/Gta	-20	0	0	probably_damaging	1	neutral	0.28	neutral	1.02	neutral	0.07	deleterious	-2.87	low_impact	1.52	0.67	neutral	0.06	damaging	3.39	23.00	deleterious	0.23	0.45	0.31	neutral	0.59	disease	0.5	neutral	0.39	neutral	2	1	deleterious	0.14	neutral	-2	neutral	0.72	deleterious	-3.43	low_impact	-0.04	medium_impact	0.29	medium_impact	0.40	0.8	NA	NA	0.26	N	0.89	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10248	10248	T	A	MI.15372	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	190	64	L	M	Tta/Ata	-20	0	0	probably_damaging	1	neutral	0.07	neutral	0.69	neutral	-2.82	neutral	-1.93	medium_impact	2.88	0.66	neutral	0.06	damaging	3.53	23.10	deleterious	0.15	0.4	0.46	neutral	0.57	disease	0.58	disease	0.61	disease	2	1	deleterious	0.04	neutral	1	deleterious	0.72	deleterious	-3.43	low_impact	-0.43	medium_impact	1.53	medium_impact	0.42	0.8	NA	NA	0.3	N	0.91	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10249	10249	T	G	MI.15373	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	191	64	L	W	tTa/tGa	-1.72	0	0	probably_damaging	1	deleterious	0.03	neutral	0.64	deleterious	-6.04	deleterious	-5.74	high_impact	4.26	0.61	neutral	0.04	damaging	3.74	23.30	deleterious	0.05	0.35	0.88	disease	0.8	disease	0.62	disease	0.64	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.43	low_impact	-0.65	medium_impact	2.8	high_impact	0.20	0.8	NA	NA	0.32	N	0.98	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10249	10249	T	C	MI.15374	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	191	64	L	S	tTa/tCa	-1.72	0	0	probably_damaging	1	neutral	0.06	neutral	0.66	deleterious	-3.88	deleterious	-5.71	high_impact	3.92	0.62	neutral	0.04	damaging	3.84	23.40	deleterious	0.05	0.35	0.76	disease	0.73	disease	0.61	disease	0.63	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	-0.47	medium_impact	2.49	high_impact	0.23	0.8	NA	NA	0.3	N	0.97	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10250	10250	A	C	MI.15375	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	192	64	L	F	ttA/ttC	7.53	0.96	0	probably_damaging	1	neutral	0.67	neutral	0.68	deleterious	-3.23	deleterious	-3.86	high_impact	3.92	0.6	neutral	0.04	damaging	3.52	23.10	deleterious	0.14	0.4	0.51	disease	0.73	disease	0.6	disease	0.62	disease	2	1	deleterious	0.34	neutral	2	deleterious	0.77	deleterious	-3.43	low_impact	0.36	medium_impact	2.49	high_impact	0.33	0.8	NA	NA	0.5	N	0.99	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10250	10250	A	T	MI.15376	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	192	64	L	F	ttA/ttT	7.53	0.96	0	probably_damaging	1	neutral	0.67	neutral	0.68	deleterious	-3.23	deleterious	-3.86	high_impact	3.92	0.6	neutral	0.04	damaging	3.56	23.10	deleterious	0.14	0.4	0.51	disease	0.73	disease	0.6	disease	0.62	disease	2	1	deleterious	0.34	neutral	2	deleterious	0.77	deleterious	-3.43	low_impact	0.36	medium_impact	2.49	high_impact	0.33	0.8	NA	NA	0.5	N	0.99	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10251	10251	T	C	MI.15377	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	193	65	F	L	Ttt/Ctt	-3.11	0	0	probably_damaging	1	neutral	1	neutral	-0.64	deleterious	-6.03	deleterious	-5.69	high_impact	3.88	0.58	damaging	0.09	damaging	3.91	23.50	deleterious	0.06	0.35	0.5	neutral	0.87	disease	0.7	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.43	low_impact	1.85	high_impact	2.45	high_impact	0.16	0.8	1.74	6.53	0.34	N	0.91	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10251	10251	T	A	MI.15378	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	193	65	F	I	Ttt/Att	-3.11	0	0	probably_damaging	1	neutral	0.46	neutral	-0.67	deleterious	-7.29	deleterious	-5.68	high_impact	4.24	0.6	damaging	0.09	damaging	4.28	24.00	deleterious	0.09	0.35	0.66	disease	0.87	disease	0.75	disease	0.69	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.80	deleterious	-3.43	low_impact	0.15	medium_impact	2.78	high_impact	0.24	0.8	1.74	6.53	0.42	N	0.95	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10251	10251	T	G	MI.15379	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	193	65	F	V	Ttt/Gtt	-3.11	0	0	probably_damaging	1	neutral	0.12	neutral	-0.67	deleterious	-7.25	deleterious	-6.62	high_impact	4.58	0.61	neutral	0.12	damaging	3.90	23.50	deleterious	0.09	0.35	0.67	disease	0.88	disease	0.76	disease	0.7	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	-0.29	medium_impact	3.09	high_impact	0.18	0.8	1.74	6.53	0.48	N	0.96	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8409	8409	C	A	MI.1538	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	44	15	P	H	cCc/cAc	-1.26	0	0	probably_damaging	1	neutral	0.17	neutral	1.98	neutral	-1.41	neutral	-1.54	low_impact	1.36	0.95	neutral	0.44	neutral	3.79	23.40	deleterious	0.47634976	0.85	0.7	disease	0.21	neutral	0.66	disease	0.16	neutral	7	1	deleterious	0.09	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	-0.1	medium_impact	0.07	medium_impact	0.62	0.85	8.82	7.31	0.48	N	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10252	10252	T	A	MI.15380	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	194	65	F	Y	tTt/tAt	7.53	1	0	probably_damaging	1	neutral	0.09	neutral	-0.51	deleterious	-4.02	deleterious	-2.85	high_impact	4.92	0.64	neutral	0.1	damaging	4.27	24.00	deleterious	0.12	0.4	0.45	neutral	0.81	disease	0.73	disease	0.69	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.78	deleterious	-3.43	low_impact	-0.37	medium_impact	3.4	high_impact	0.38	0.8	1.74	6.53	0.77	P	0.89	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10252	10252	T	C	MI.15381	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	194	65	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	deleterious	0.04	neutral	-0.68	deleterious	-7.87	deleterious	-7.59	high_impact	4.38	0.6	neutral	0.09	damaging	4.26	23.90	deleterious	0.05	0.35	0.78	disease	0.87	disease	0.73	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.43	low_impact	-0.58	medium_impact	2.91	high_impact	0.13	0.8	1.74	6.53	0.57	P	0.97	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10252	10252	T	G	MI.15382	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	194	65	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0.02	neutral	-0.69	deleterious	-9.36	deleterious	-7.5	high_impact	4.92	0.62	neutral	0.09	damaging	4.09	23.70	deleterious	0.05	0.35	0.9	disease	0.87	disease	0.74	disease	0.61	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.43	low_impact	-0.75	medium_impact	3.4	high_impact	0.12	0.8	1.74	6.53	0.63	P	0.99	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10253	10253	T	G	MI.15383	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	195	65	F	L	ttT/ttG	5.68	1	0	probably_damaging	1	neutral	1	neutral	-0.64	deleterious	-6.03	deleterious	-5.69	high_impact	3.88	0.58	damaging	0.09	damaging	4.32	24.00	deleterious	0.06	0.35	0.5	neutral	0.87	disease	0.7	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.43	low_impact	1.85	high_impact	2.45	high_impact	0.16	0.8	1.74	6.53	0.56	P	0.91	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10253	10253	T	A	MI.15384	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	195	65	F	L	ttT/ttA	5.68	1	0	probably_damaging	1	neutral	1	neutral	-0.64	deleterious	-6.03	deleterious	-5.69	high_impact	3.88	0.58	damaging	0.09	damaging	4.41	24.10	deleterious	0.06	0.35	0.5	neutral	0.87	disease	0.7	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.43	low_impact	1.85	high_impact	2.45	high_impact	0.16	0.8	1.74	6.53	0.57	P	0.91	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10254	10254	G	A	MI.15385	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	196	66	D	N	Gat/Aat	-3.34	0	0	probably_damaging	1	neutral	0.11	neutral	-0.36	deleterious	-5.25	deleterious	-4.77	high_impact	4.58	0.39	damaging	0.05	damaging	4.18	23.80	deleterious	0.29	0.45	0.63	disease	0.82	disease	0.77	disease	0.69	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	-0.31	medium_impact	3.09	high_impact	0.65	0.8	0.87	6.92	0.56	P	0.98	disease_causing_automatic	0	0.84	rs587776438	Pathogenic	Leigh_syndrome	165636	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	.	.	G10254A	Leigh Disease	-	+	Reported	1	P	P	P	damaging
chrM	10254	10254	G	C	MI.15386	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	196	66	D	H	Gat/Cat	-3.34	0	0	probably_damaging	1	neutral	0.18	neutral	-0.4	deleterious	-7.07	deleterious	-6.7	high_impact	4.58	0.48	damaging	0.04	damaging	3.62	23.20	deleterious	0.07	0.35	0.83	disease	0.88	disease	0.8	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	-0.18	medium_impact	3.09	high_impact	0.37	0.8	0.87	6.92	0.48	N	0.99	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10254	10254	G	T	MI.15387	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	196	66	D	Y	Gat/Tat	-3.34	0	0	probably_damaging	1	neutral	0.34	neutral	-0.41	deleterious	-8.27	deleterious	-8.62	high_impact	4.93	0.5	damaging	0.04	damaging	3.90	23.50	deleterious	0.04	0.35	0.89	disease	0.92	disease	0.8	disease	0.63	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	0.03	medium_impact	3.41	high_impact	0.15	0.8	0.87	6.92	0.54	P	1.00	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10255	10255	A	C	MI.15388	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	197	66	D	A	gAt/gCt	7.3	1	0	probably_damaging	1	neutral	0.22	neutral	-0.37	deleterious	-5.54	deleterious	-7.62	high_impact	4.24	0.57	damaging	0.07	damaging	3.71	23.30	deleterious	0.06	0.35	0.69	disease	0.81	disease	0.76	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	-0.12	medium_impact	2.78	high_impact	0.33	0.8	0.87	6.92	0.64	P	0.94	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10255	10255	A	G	MI.15389	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	197	66	D	G	gAt/gGt	7.3	1	0	probably_damaging	1	neutral	0.14	neutral	-0.38	deleterious	-6.03	deleterious	-6.69	high_impact	4.93	0.47	damaging	0.08	damaging	4.07	23.70	deleterious	0.07	0.35	0.69	disease	0.87	disease	0.76	disease	0.69	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	-0.25	medium_impact	3.41	high_impact	0.33	0.8	0.87	6.92	0.69	P	0.98	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8409	8409	C	G	MI.1539	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	44	15	P	R	cCc/cGc	-1.26	0	0	probably_damaging	1	neutral	0.11	neutral	1.99	neutral	-0.88	neutral	-1.51	low_impact	1.36	0.99	neutral	0.44	neutral	2.30	18.20	deleterious	0.37202141	0.85	0.55	disease	0.28	neutral	0.64	disease	0.14	neutral	7	1	deleterious	0.06	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	-0.22	medium_impact	0.07	medium_impact	0.72	0.85	8.82	7.31	0.55	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10255	10255	A	T	MI.15390	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	197	66	D	V	gAt/gTt	7.3	1	0	probably_damaging	1	neutral	0.69	neutral	-0.41	deleterious	-7.53	deleterious	-8.62	high_impact	4.93	0.43	damaging	0.05	damaging	3.78	23.40	deleterious	0.03	0.35	0.84	disease	0.91	disease	0.77	disease	0.65	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	0.38	medium_impact	3.41	high_impact	0.16	0.8	0.87	6.92	0.71	P	0.99	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10256	10256	T	A	MI.15391	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	198	66	D	E	gaT/gaA	8.69	1	0	probably_damaging	1	neutral	0.22	neutral	-0.29	deleterious	-4.14	deleterious	-3.81	high_impact	3.78	0.54	damaging	0.09	damaging	4.10	23.70	deleterious	0.15	0.4	0.51	disease	0.81	disease	0.73	disease	0.68	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	-0.12	medium_impact	2.36	high_impact	0.48	0.8	0.87	6.92	0.64	P	0.93	polymorphism	0.97	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10256	10256	T	G	MI.15392	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	198	66	D	E	gaT/gaG	8.69	1	0	probably_damaging	1	neutral	0.22	neutral	-0.29	deleterious	-4.14	deleterious	-3.81	high_impact	3.78	0.54	damaging	0.09	damaging	3.92	23.50	deleterious	0.15	0.4	0.51	disease	0.81	disease	0.73	disease	0.68	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	-0.12	medium_impact	2.36	high_impact	0.48	0.8	0.87	6.92	0.64	P	0.93	polymorphism	0.97	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10257	10257	C	A	MI.15393	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	199	67	L	M	Cta/Ata	-0.1	0	0	probably_damaging	1	neutral	0.23	neutral	0.64	neutral	-2.71	neutral	-1.94	medium_impact	3.26	0.49	damaging	0.02	damaging	3.89	23.50	deleterious	0.2	0.45	0.46	neutral	0.52	disease	0.6	disease	0.61	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.72	deleterious	-3.43	low_impact	-0.1	medium_impact	1.88	medium_impact	0.77	0.85	NA	NA	0.39	N	0.91	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10257	10257	C	G	MI.15394	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	199	67	L	V	Cta/Gta	-0.1	0	0	probably_damaging	1	neutral	0.89	neutral	1.01	neutral	1.11	deleterious	-2.9	low_impact	1.34	0.44	damaging	0.02	damaging	3.38	23.00	deleterious	0.26	0.45	0.21	neutral	0.33	neutral	0.36	neutral	0.4	neutral	2	1	deleterious	0.45	neutral	-2	neutral	0.70	deleterious	-3.43	low_impact	0.69	medium_impact	0.12	medium_impact	0.63	0.8	NA	NA	0.36	N	0.89	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10258	10258	T	A	MI.15395	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	200	67	L	Q	cTa/cAa	-0.33	0	0	probably_damaging	1	neutral	0.14	neutral	0.58	deleterious	-4.94	deleterious	-5.81	high_impact	4.46	0.46	damaging	0.02	damaging	4.02	23.60	deleterious	0.04	0.35	0.8	disease	0.76	disease	0.62	disease	0.63	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	-0.25	medium_impact	2.98	high_impact	0.30	0.8	NA	NA	0.41	N	0.97	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10258	10258	T	C	MI.15396	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	200	67	L	P	cTa/cCa	-0.33	0	0	probably_damaging	1	neutral	0.1	neutral	0.58	deleterious	-4.8	deleterious	-6.79	high_impact	3.77	0.44	damaging	0.01	damaging	3.91	23.50	deleterious	0.03	0.35	0.84	disease	0.8	disease	0.72	disease	0.65	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	-0.34	medium_impact	2.35	high_impact	0.24	0.8	NA	NA	0.42	N	0.99	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10258	10258	T	G	MI.15397	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	200	67	L	R	cTa/cGa	-0.33	0	0	probably_damaging	1	neutral	0.16	neutral	0.58	deleterious	-4.84	deleterious	-5.81	high_impact	4.46	0.52	damaging	0.02	damaging	4.21	23.90	deleterious	0.02	0.35	0.8	disease	0.88	disease	0.72	disease	0.67	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	-0.21	medium_impact	2.98	high_impact	0.20	0.8	NA	NA	0.42	N	1.00	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10260	10260	G	A	MI.15398	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	202	68	E	K	Gaa/Aaa	-0.1	0.75	0	benign	0.18	neutral	0.29	neutral	-0.07	deleterious	-5.14	deleterious	-3.86	high_impact	4.93	0.37	damaging	0.03	damaging	4.47	24.20	deleterious	0.06	0.35	0.63	disease	0.87	disease	0.84	disease	0.73	disease	5	0.66	neutral	0.56	deleterious	-2	neutral	0.54	deleterious	-0.12	medium_impact	-0.03	medium_impact	3.41	high_impact	0.70	0.85	3.48	7.62	0.7	P	0.99	polymorphism	1	0.84	rs28655588	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10260	10260	G	C	MI.15399	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	202	68	E	Q	Gaa/Caa	-0.1	0.75	0	probably_damaging	0.91	neutral	0.29	neutral	-0.08	deleterious	-5.22	deleterious	-2.9	high_impact	4.93	0.39	damaging	0.03	damaging	3.30	22.90	deleterious	0.11	0.4	0.68	disease	0.74	disease	0.75	disease	0.69	disease	4	0.93	neutral	0.19	neutral	2	deleterious	0.78	deleterious	-1.62	low_impact	-0.03	medium_impact	3.41	high_impact	0.55	0.8	3.48	7.62	0.69	P	0.90	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8598	8598	T	G	MI.154	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	72	24	I	M	atT/atG	3.83	0.43	0	probably_damaging	1	neutral	0.35	neutral	3.96	neutral	-2.76	neutral	-1.44	neutral_impact	-0.32	0.87	neutral	0.96	neutral	1.69	14.33	neutral	0.5	0.65	0.56	disease	0.13	neutral	0.27	neutral	0.29	neutral	4	1	deleterious	0.18	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.14	medium_impact	-1.37	low_impact	0.70	0.9	18.14	17.22	0.45	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8411	8411	A	G	MI.1540	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	46	16	M	V	Ata/Gta	-6.12	0	0	possibly_damaging	0.75	neutral	0.52	neutral	1.94	neutral	1.33	deleterious	-3.28	medium_impact	2	1	neutral	0.68	neutral	2.35	18.52	deleterious	0.57262910	0.85	0.4	neutral	0.4	neutral	0.64	disease	0.18	neutral	6	0.73	neutral	0.39	neutral	0	NA	0.48	deleterious	-1.21	low_impact	0.31	medium_impact	0.62	medium_impact	0.53	0.85	NA	NA	0.39	N	0.61	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	A8411G	Severe mitochondrial disorder	+	-	Reported	1	.	P	P	neutral
chrM	10261	10261	A	G	MI.15400	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	203	68	E	G	gAa/gGa	6.14	1	0	probably_damaging	0.94	neutral	0.32	neutral	-0.08	deleterious	-5.26	deleterious	-6.76	high_impact	4.59	0.38	damaging	0.05	damaging	4.03	23.70	deleterious	0.06	0.35	0.68	disease	0.75	disease	0.77	disease	0.69	disease	4	0.94	neutral	0.19	neutral	2	deleterious	0.80	deleterious	-1.8	low_impact	0.01	medium_impact	3.1	high_impact	0.10	0.8	3.48	7.62	0.74	P	0.61	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10261	10261	A	C	MI.15401	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	203	68	E	A	gAa/gCa	6.14	1	0	possibly_damaging	0.81	neutral	0.52	neutral	-0.08	deleterious	-5.32	deleterious	-5.79	high_impact	4.93	0.45	damaging	0.07	damaging	3.51	23.10	deleterious	0.06	0.35	0.66	disease	0.7	disease	0.75	disease	0.69	disease	4	0.79	neutral	0.36	neutral	1	deleterious	0.78	deleterious	-1.29	low_impact	0.21	medium_impact	3.41	high_impact	0.27	0.8	3.48	7.62	0.69	P	0.76	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10261	10261	A	T	MI.15402	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	203	68	E	V	gAa/gTa	6.14	1	0	probably_damaging	0.95	neutral	0.58	neutral	-0.11	deleterious	-6.94	deleterious	-6.77	high_impact	4.93	0.38	damaging	0.04	damaging	4.00	23.60	deleterious	0.05	0.35	0.8	disease	0.85	disease	0.81	disease	0.68	disease	4	0.95	neutral	0.32	neutral	2	deleterious	0.86	deleterious	-1.87	low_impact	0.27	medium_impact	3.41	high_impact	0.21	0.8	3.48	7.62	0.76	P	0.84	polymorphism	1	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10262	10262	A	T	MI.15403	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	204	68	E	D	gaA/gaT	6.84	1	0	possibly_damaging	0.84	neutral	0.33	neutral	0.12	neutral	-2.71	deleterious	-2.9	high_impact	4.04	0.41	damaging	0.03	damaging	3.87	23.50	deleterious	0.15	0.4	0.5	neutral	0.73	disease	0.76	disease	0.68	disease	4	0.86	neutral	0.25	neutral	1	deleterious	0.75	deleterious	-1.37	low_impact	0.02	medium_impact	2.6	high_impact	0.50	0.8	3.48	7.62	0.8	P	0.86	polymorphism	0.98	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10262	10262	A	C	MI.15404	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	204	68	E	D	gaA/gaC	6.84	1	0	possibly_damaging	0.84	neutral	0.33	neutral	0.12	neutral	-2.71	deleterious	-2.9	high_impact	4.04	0.41	damaging	0.03	damaging	3.72	23.30	deleterious	0.15	0.4	0.5	neutral	0.73	disease	0.76	disease	0.68	disease	4	0.86	neutral	0.25	neutral	1	deleterious	0.75	deleterious	-1.37	low_impact	0.02	medium_impact	2.6	high_impact	0.50	0.8	3.48	7.62	0.79	P	0.86	polymorphism	0.98	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10263	10263	A	C	MI.15405	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	205	69	I	L	Att/Ctt	3.37	1	0	probably_damaging	0.99	neutral	0.67	neutral	0.92	neutral	-0.54	neutral	-1.85	medium_impact	2.86	0.5	damaging	0.06	damaging	3.55	23.10	deleterious	0.2	0.45	0.34	neutral	0.71	disease	0.56	disease	0.63	disease	3	0.99	deleterious	0.34	neutral	1	deleterious	0.72	deleterious	-2.52	low_impact	0.36	medium_impact	1.51	medium_impact	0.45	0.8	NA	NA	0.5	N	0.85	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10263	10263	A	T	MI.15406	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	205	69	I	F	Att/Ttt	3.37	1	0	probably_damaging	1	neutral	0.71	neutral	0.8	neutral	-2	deleterious	-3.79	high_impact	4.66	0.49	damaging	0.06	damaging	3.54	23.10	deleterious	0.1	0.4	0.66	disease	0.77	disease	0.64	disease	0.65	disease	3	1	deleterious	0.36	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.41	medium_impact	3.16	high_impact	0.47	0.8	NA	NA	0.59	P	0.97	polymorphism	1	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10263	10263	A	G	MI.15407	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	205	69	I	V	Att/Gtt	3.37	1	0	probably_damaging	0.99	neutral	0.56	neutral	0.98	neutral	-0.1	neutral	-0.94	low_impact	1.75	0.56	damaging	0.1	damaging	2.81	21.40	deleterious	0.28	0.45	0.28	neutral	0.41	neutral	0.53	disease	0.42	neutral	2	0.99	deleterious	0.29	neutral	-2	neutral	0.65	deleterious	-2.52	low_impact	0.25	medium_impact	0.5	medium_impact	0.32	0.8	NA	NA	0.44	N	0.79	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10264	10264	T	C	MI.15408	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	206	69	I	T	aTt/aCt	8.69	1	0	probably_damaging	1	neutral	0.41	neutral	0.83	neutral	-1.48	deleterious	-4.74	medium_impact	2.7	0.51	damaging	0.07	damaging	3.41	23.00	deleterious	0.07	0.35	0.66	disease	0.67	disease	0.61	disease	0.64	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.43	low_impact	0.1	medium_impact	1.37	medium_impact	0.32	0.8	NA	NA	0.57	P	0.99	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10264	10264	T	G	MI.15409	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	206	69	I	S	aTt/aGt	8.69	1	0	probably_damaging	1	neutral	0.41	neutral	0.8	neutral	-2.07	deleterious	-5.68	high_impact	3.69	0.54	damaging	0.08	damaging	4.29	24.00	deleterious	0.04	0.35	0.74	disease	0.81	disease	0.62	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.43	low_impact	0.1	medium_impact	2.28	high_impact	0.27	0.8	NA	NA	0.57	P	0.96	polymorphism	1	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8411	8411	A	T	MI.1541	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	46	16	M	L	Ata/Tta	-6.12	0	0	possibly_damaging	0.66	neutral	0.64	neutral	2.05	neutral	1.38	deleterious	-2.55	medium_impact	2.63	0.97	neutral	0.4	neutral	3.00	22.20	deleterious	0.54043948	0.85	0.37	neutral	0.49	neutral	0.7	disease	0.45	neutral	1	0.59	neutral	0.49	deleterious	0	NA	0.43	deleterious	-1.03	low_impact	0.43	medium_impact	1.16	medium_impact	0.50	0.85	NA	NA	0.36	N	0.58	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10264	10264	T	A	MI.15410	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	206	69	I	N	aTt/aAt	8.69	1	0	probably_damaging	1	neutral	0.31	neutral	0.75	deleterious	-3.7	deleterious	-6.66	high_impact	4.66	0.48	damaging	0.06	damaging	4.52	24.30	deleterious	0.07	0.35	0.84	disease	0.85	disease	0.64	disease	0.63	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	0	medium_impact	3.16	high_impact	0.33	0.8	NA	NA	0.65	P	0.99	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10265	10265	T	A	MI.15411	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	207	69	I	M	atT/atA	5.68	1	0	probably_damaging	1	neutral	0.23	neutral	0.84	neutral	-1.3	deleterious	-2.71	medium_impact	3.38	0.61	neutral	0.08	damaging	3.71	23.30	deleterious	0.13	0.4	0.64	disease	0.67	disease	0.54	disease	0.61	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.73	deleterious	-3.43	low_impact	-0.1	medium_impact	1.99	medium_impact	0.43	0.8	NA	NA	0.64	P	0.78	polymorphism	0.99	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10265	10265	T	G	MI.15412	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	207	69	I	M	atT/atG	5.68	1	0	probably_damaging	1	neutral	0.23	neutral	0.84	neutral	-1.3	deleterious	-2.71	medium_impact	3.38	0.61	neutral	0.08	damaging	3.42	23.00	deleterious	0.13	0.4	0.64	disease	0.67	disease	0.54	disease	0.61	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.73	deleterious	-3.43	low_impact	-0.1	medium_impact	1.99	medium_impact	0.43	0.8	NA	NA	0.63	P	0.78	polymorphism	0.99	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10266	10266	G	C	MI.15413	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	208	70	A	P	Gcc/Ccc	-4.73	0	0	probably_damaging	1	neutral	0.19	neutral	0.86	deleterious	-3.71	deleterious	-4.75	high_impact	4.12	0.52	damaging	0.05	damaging	3.79	23.40	deleterious	0.04	0.35	0.67	disease	0.85	disease	0.71	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	-0.16	medium_impact	2.67	high_impact	0.51	0.8	NA	NA	0.34	N	0.96	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10266	10266	G	T	MI.15414	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	208	70	A	S	Gcc/Tcc	-4.73	0	0	probably_damaging	1	neutral	0.29	neutral	0.95	neutral	-2.09	deleterious	-2.83	medium_impact	2.38	0.58	damaging	0.05	damaging	3.70	23.30	deleterious	0.25	0.45	0.25	neutral	0.7	disease	0.57	disease	0.53	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.72	deleterious	-3.43	low_impact	-0.03	medium_impact	1.07	medium_impact	0.35	0.8	NA	NA	0.25	N	0.98	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10266	10266	G	A	MI.15415	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	208	70	A	T	Gcc/Acc	-4.73	0	0	probably_damaging	1	neutral	0.34	neutral	0.94	neutral	-1.65	deleterious	-3.67	medium_impact	2.44	0.52	damaging	0.32	neutral	4.21	23.90	deleterious	0.16	0.45	0.45	neutral	0.6	disease	0.38	neutral	0.17	neutral	7	1	deleterious	0.17	neutral	1	deleterious	0.73	deleterious	-3.43	low_impact	0.03	medium_impact	1.13	medium_impact	0.72	0.85	NA	NA	0.41	N	0.93	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10267	10267	C	A	MI.15416	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	209	70	A	D	gCc/gAc	2.9	0.99	0	probably_damaging	1	neutral	0.29	neutral	0.85	deleterious	-4.07	deleterious	-5.69	high_impact	4.46	0.59	damaging	0.03	damaging	4.50	24.30	deleterious	0.03	0.35	0.69	disease	0.88	disease	0.69	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.80	deleterious	-3.43	low_impact	-0.03	medium_impact	2.98	high_impact	0.26	0.8	NA	NA	0.57	P	0.96	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10267	10267	C	T	MI.15417	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	209	70	A	V	gCc/gTc	2.9	0.99	0	probably_damaging	1	neutral	0.73	neutral	1.11	neutral	1.1	deleterious	-3.69	low_impact	1.6	0.5	damaging	0.06	damaging	4.48	24.20	deleterious	0.17	0.45	0.57	disease	0.67	disease	0.5	neutral	0.21	neutral	6	1	deleterious	0.37	neutral	-2	neutral	0.74	deleterious	-3.43	low_impact	0.43	medium_impact	0.36	medium_impact	0.68	0.85	NA	NA	0.44	N	0.79	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10267	10267	C	G	MI.15418	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	209	70	A	G	gCc/gGc	2.9	0.99	0	probably_damaging	1	neutral	0.2	neutral	0.86	deleterious	-3.29	deleterious	-3.83	high_impact	4.46	0.54	damaging	0.08	damaging	4.01	23.60	deleterious	0.21	0.45	0.49	neutral	0.69	disease	0.58	disease	0.62	disease	2	1	deleterious	0.1	neutral	2	deleterious	0.73	deleterious	-3.43	low_impact	-0.14	medium_impact	2.98	high_impact	0.63	0.8	NA	NA	0.56	P	0.85	polymorphism	1	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10269	10269	C	G	MI.15419	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	211	71	L	V	Ctc/Gtc	-4.96	0	0	probably_damaging	1	neutral	0.37	neutral	0.56	neutral	-1.44	deleterious	-2.73	high_impact	3.9	0.41	damaging	0.05	damaging	3.45	23.00	deleterious	0.24	0.45	0.35	neutral	0.46	neutral	0.63	disease	0.47	neutral	1	1	deleterious	0.19	neutral	2	deleterious	0.70	deleterious	-3.43	low_impact	0.06	medium_impact	2.47	high_impact	0.46	0.8	NA	NA	0.49	N	0.89	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8411	8411	A	C	MI.1542	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	46	16	M	L	Ata/Cta	-6.12	0	0	possibly_damaging	0.66	neutral	0.64	neutral	2.05	neutral	1.38	deleterious	-2.55	medium_impact	2.63	0.97	neutral	0.4	neutral	2.86	21.70	deleterious	0.54043948	0.85	0.37	neutral	0.49	neutral	0.7	disease	0.45	neutral	1	0.59	neutral	0.49	deleterious	0	NA	0.43	deleterious	-1.03	low_impact	0.43	medium_impact	1.16	medium_impact	0.50	0.85	NA	NA	0.29	N	0.58	polymorphism	1	0.31	rs878942289	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10269	10269	C	A	MI.15420	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	211	71	L	I	Ctc/Atc	-4.96	0	0	probably_damaging	1	neutral	0.72	neutral	0.6	neutral	-1.52	neutral	-1.77	medium_impact	2.54	0.61	neutral	0.48	neutral	4.06	23.70	deleterious	0.2	0.45	0.24	neutral	0.5	neutral	0.41	neutral	0.17	neutral	7	1	deleterious	0.36	neutral	1	deleterious	0.69	deleterious	-3.43	low_impact	0.42	medium_impact	1.22	medium_impact	0.57	0.8	NA	NA	0.31	N	0.86	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10269	10269	C	T	MI.15421	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	211	71	L	F	Ctc/Ttc	-4.96	0	0	probably_damaging	1	neutral	0.27	neutral	0.69	neutral	1.88	deleterious	-3.79	low_impact	1.89	0.44	damaging	0.05	damaging	3.98	23.60	deleterious	0.21	0.45	0.53	disease	0.58	disease	0.6	disease	0.62	disease	2	1	deleterious	0.14	neutral	-2	neutral	0.74	deleterious	-3.43	low_impact	-0.05	medium_impact	0.62	medium_impact	0.44	0.8	NA	NA	0.38	N	0.99	polymorphism	1	0.51	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10270	10270	T	C	MI.15422	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	212	71	L	P	cTc/cCc	1.05	0.43	0	probably_damaging	1	neutral	0.16	neutral	0.46	deleterious	-4.27	deleterious	-6.7	high_impact	4.6	0.4	damaging	0.04	damaging	3.91	23.50	deleterious	0.02	0.35	0.86	disease	0.75	disease	0.74	disease	0.66	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	-0.21	medium_impact	3.11	high_impact	0.23	0.8	NA	NA	0.6	P	0.99	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10270	10270	T	A	MI.15423	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	212	71	L	H	cTc/cAc	1.05	0.43	0	probably_damaging	1	neutral	0.16	neutral	0.46	deleterious	-3.51	deleterious	-6.69	high_impact	4.6	0.45	damaging	0.04	damaging	4.13	23.80	deleterious	0.04	0.35	0.89	disease	0.76	disease	0.71	disease	0.65	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.80	deleterious	-3.43	low_impact	-0.21	medium_impact	3.11	high_impact	0.28	0.8	NA	NA	0.48	P	0.97	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10270	10270	T	G	MI.15424	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	212	71	L	R	cTc/cGc	1.05	0.43	0	probably_damaging	1	neutral	0.19	neutral	0.47	deleterious	-3.6	deleterious	-5.76	high_impact	4.6	0.46	damaging	0.03	damaging	4.20	23.90	deleterious	0.02	0.35	0.82	disease	0.84	disease	0.75	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	-0.16	medium_impact	3.11	high_impact	0.17	0.8	NA	NA	0.53	P	1.00	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10272	10272	C	T	MI.15425	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	214	72	L	F	Ctt/Ttt	-20	0	0	probably_damaging	1	neutral	0.19	neutral	0.22	deleterious	-3.17	deleterious	-3.87	medium_impact	3.03	0.45	damaging	0.01	damaging	3.94	23.50	deleterious	0.14	0.4	0.53	disease	0.52	disease	0.69	disease	0.65	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.75	deleterious	-3.43	low_impact	-0.16	medium_impact	1.67	medium_impact	0.40	0.8	1.74	6.76	0.34	N	0.99	polymorphism	1	0.56	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10272	10272	C	G	MI.15426	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	214	72	L	V	Ctt/Gtt	-20	0	0	probably_damaging	1	neutral	0.13	neutral	0.18	deleterious	-3.71	deleterious	-2.9	medium_impact	3.38	0.45	damaging	0.03	damaging	3.43	23.00	deleterious	0.22	0.45	0.36	neutral	0.4	neutral	0.7	disease	0.46	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.71	deleterious	-3.43	low_impact	-0.27	medium_impact	1.99	medium_impact	0.53	0.8	1.74	6.76	0.37	N	0.89	polymorphism	1	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10272	10272	C	A	MI.15427	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	214	72	L	I	Ctt/Att	-20	0	0	probably_damaging	1	neutral	0.32	neutral	0.4	neutral	-1.89	neutral	-1.94	medium_impact	2.32	0.45	damaging	0.04	damaging	4.15	23.80	deleterious	0.23	0.45	0.25	neutral	0.34	neutral	0.46	neutral	0.39	neutral	2	1	deleterious	0.16	neutral	1	deleterious	0.70	deleterious	-3.43	low_impact	0.01	medium_impact	1.02	medium_impact	0.48	0.8	1.74	6.76	0.38	N	0.86	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10273	10273	T	A	MI.15428	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	215	72	L	H	cTt/cAt	1.29	0.72	0	probably_damaging	1	deleterious	0.04	neutral	0.09	deleterious	-7.8	deleterious	-6.78	high_impact	4.73	0.47	damaging	0.01	damaging	4.06	23.70	deleterious	0.05	0.35	0.89	disease	0.72	disease	0.76	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-3.43	low_impact	-0.58	medium_impact	3.23	high_impact	0.32	0.8	1.74	6.76	0.56	P	0.97	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10273	10273	T	C	MI.15429	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	215	72	L	P	cTt/cCt	1.29	0.72	0	probably_damaging	1	neutral	0.19	neutral	0.1	deleterious	-7.49	deleterious	-6.79	high_impact	4.73	0.41	damaging	0.02	damaging	3.76	23.40	deleterious	0.03	0.35	0.86	disease	0.72	disease	0.79	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.16	medium_impact	3.23	high_impact	0.31	0.8	1.74	6.76	0.67	P	0.99	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8412	8412	T	A	MI.1543	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	47	16	M	K	aTa/aAa	0.59	0	0	possibly_damaging	0.88	neutral	0.29	neutral	1.8	neutral	-0.46	deleterious	-5.2	medium_impact	3.33	0.99	neutral	0.31	neutral	3.72	23.30	deleterious	0.32107757	0.85	0.53	disease	0.66	disease	0.79	disease	0.64	disease	3	0.9	neutral	0.21	neutral	0	NA	0.73	deleterious	-1.58	low_impact	0.07	medium_impact	1.76	medium_impact	0.42	0.85	NA	NA	0.52	N	0.79	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10273	10273	T	G	MI.15430	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	215	72	L	R	cTt/cGt	1.29	0.72	0	probably_damaging	1	deleterious	0.03	neutral	0.1	deleterious	-7.09	deleterious	-5.81	high_impact	4.73	0.5	damaging	0.02	damaging	4.11	23.70	deleterious	0.03	0.35	0.82	disease	0.8	disease	0.8	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-3.43	low_impact	-0.65	medium_impact	3.23	high_impact	0.28	0.8	1.74	6.76	0.58	P	1.00	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10275	10275	T	G	MI.15431	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	217	73	L	V	Tta/Gta	-14.22	0	0	possibly_damaging	0.87	neutral	0.11	neutral	0.69	neutral	-0.87	deleterious	-2.8	medium_impact	2.89	0.57	damaging	0.03	damaging	3.41	23.00	deleterious	0.26	0.45	0.5	disease	0.4	neutral	0.63	disease	0.39	neutral	2	0.95	neutral	0.12	neutral	0	NA	0.71	deleterious	-1.46	low_impact	-0.31	medium_impact	1.54	medium_impact	0.57	0.8	NA	NA	0.31	N	0.89	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10275	10275	T	A	MI.15432	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	217	73	L	M	Tta/Ata	-14.22	0	0	probably_damaging	0.99	neutral	0.05	neutral	0.64	neutral	-1.9	neutral	-1.87	medium_impact	2.33	0.65	neutral	0.04	damaging	3.59	23.20	deleterious	0.22	0.45	0.59	disease	0.39	neutral	0.41	neutral	0.54	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.72	deleterious	-2.52	low_impact	-0.52	medium_impact	1.03	medium_impact	0.42	0.8	NA	NA	0.32	N	0.91	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10276	10276	T	G	MI.15433	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	218	73	L	W	tTa/tGa	-0.1	0	0	probably_damaging	1	deleterious	0.03	neutral	0.58	neutral	-2.42	deleterious	-5.65	high_impact	3.87	0.56	damaging	0.02	damaging	3.64	23.20	deleterious	0.05	0.35	0.91	disease	0.64	disease	0.65	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-3.43	low_impact	-0.65	medium_impact	2.44	high_impact	0.26	0.8	NA	NA	0.32	N	0.98	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10276	10276	T	C	MI.15434	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	218	73	L	S	tTa/tCa	-0.1	0	0	probably_damaging	0.96	neutral	0.11	neutral	0.61	neutral	-2.11	deleterious	-5.59	high_impact	3.72	0.53	damaging	0.04	damaging	3.67	23.30	deleterious	0.04	0.35	0.8	disease	0.6	disease	0.65	disease	0.67	disease	3	0.98	deleterious	0.08	neutral	2	deleterious	0.80	deleterious	-1.96	low_impact	-0.31	medium_impact	2.3	high_impact	0.28	0.8	NA	NA	0.34	N	0.97	polymorphism	1	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10277	10277	A	C	MI.15435	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	219	73	L	F	ttA/ttC	7.53	0.96	0	probably_damaging	0.99	neutral	0.33	neutral	0.78	neutral	1.56	deleterious	-3.77	low_impact	1.07	0.56	damaging	0.02	damaging	3.44	23.00	deleterious	0.22	0.45	0.61	disease	0.43	neutral	0.42	neutral	0.52	disease	0	0.99	deleterious	0.17	neutral	-2	neutral	0.76	deleterious	-2.52	low_impact	0.02	medium_impact	-0.13	medium_impact	0.38	0.8	NA	NA	0.48	N	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10277	10277	A	T	MI.15436	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	219	73	L	F	ttA/ttT	7.53	0.96	0	probably_damaging	0.99	neutral	0.33	neutral	0.78	neutral	1.56	deleterious	-3.77	low_impact	1.07	0.56	damaging	0.02	damaging	3.54	23.10	deleterious	0.22	0.45	0.61	disease	0.43	neutral	0.42	neutral	0.52	disease	0	0.99	deleterious	0.17	neutral	-2	neutral	0.76	deleterious	-2.52	low_impact	0.02	medium_impact	-0.13	medium_impact	0.38	0.8	NA	NA	0.49	N	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10278	10278	C	A	MI.15437	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	220	74	P	T	Ccc/Acc	-20	0	0	possibly_damaging	0.81	neutral	0.19	neutral	0.45	deleterious	-3.49	deleterious	-7.66	high_impact	3.92	0.54	damaging	0.31	neutral	3.67	23.30	deleterious	0.05	0.35	0.97	disease	0.76	disease	0.71	disease	0.69	disease	4	0.89	neutral	0.19	neutral	1	deleterious	0.78	deleterious	-1.29	low_impact	-0.16	medium_impact	2.49	high_impact	0.55	0.8	8.7	10.6	0.35	N	0.71	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10278	10278	C	G	MI.15438	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	220	74	P	A	Ccc/Gcc	-20	0	0	possibly_damaging	0.73	neutral	0.27	neutral	0.51	neutral	-2.62	deleterious	-7.66	medium_impact	3.44	0.59	damaging	0.39	neutral	3.06	22.40	deleterious	0.07	0.35	0.95	disease	0.62	disease	0.7	disease	0.74	disease	5	0.81	neutral	0.27	neutral	0	NA	0.74	deleterious	-1.11	low_impact	-0.05	medium_impact	2.05	high_impact	0.65	0.8	8.7	10.6	0.37	N	0.60	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10278	10278	C	T	MI.15439	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	220	74	P	S	Ccc/Tcc	-20	0	0	benign	0.18	neutral	0.29	neutral	0.49	neutral	-2.87	deleterious	-7.65	high_impact	3.51	0.54	damaging	0.4	neutral	3.86	23.50	deleterious	0.06	0.35	0.96	disease	0.77	disease	0.65	disease	0.69	disease	4	0.66	neutral	0.56	deleterious	-2	neutral	0.41	neutral	-0.12	medium_impact	-0.03	medium_impact	2.11	high_impact	0.15	0.8	8.7	10.6	0.36	N	0.32	polymorphism	1	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8412	8412	T	C	MI.1544	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	47	16	M	T	aTa/aCa	0.59	0	0	possibly_damaging	0.88	neutral	0.44	neutral	1.89	neutral	1.84	deleterious	-4.63	low_impact	1.05	1	neutral	0.94	neutral	1.48	13.23	neutral	0.62949060	0.85	0.45	neutral	0.28	neutral	0.62	disease	0.09	neutral	8	0.87	neutral	0.28	neutral	-3	neutral	0.66	deleterious	-1.58	low_impact	0.23	medium_impact	-0.2	medium_impact	0.42	0.85	NA	NA	0.49	N	0.71	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10279	10279	C	A	MI.15440	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	221	74	P	H	cCc/cAc	5.45	1	0	probably_damaging	0.99	neutral	0.23	neutral	0.41	deleterious	-5.03	deleterious	-8.61	high_impact	4.89	0.51	damaging	0.23	damaging	4.11	23.70	deleterious	0.03	0.35	0.99	disease	0.85	disease	0.79	disease	0.78	disease	6	0.99	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-2.52	low_impact	-0.1	medium_impact	3.38	high_impact	0.29	0.8	8.7	10.6	0.67	P	0.87	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10279	10279	C	G	MI.15441	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	221	74	P	R	cCc/cGc	5.45	1	0	probably_damaging	0.97	neutral	0.14	neutral	0.43	deleterious	-4	deleterious	-8.61	high_impact	4.89	0.56	damaging	0.28	damaging	3.58	23.20	deleterious	0.03	0.35	0.98	disease	0.88	disease	0.79	disease	0.74	disease	5	0.98	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-2.08	low_impact	-0.25	medium_impact	3.38	high_impact	0.33	0.8	8.7	10.6	0.7	P	0.90	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10279	10279	C	T	MI.15442	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	221	74	P	L	cCc/cTc	5.45	1	0	probably_damaging	0.94	neutral	1	neutral	0.44	deleterious	-3.78	deleterious	-9.54	high_impact	4.2	0.52	damaging	0.38	neutral	4.32	24.00	deleterious	0.04	0.35	0.98	disease	0.86	disease	0.68	disease	0.69	disease	4	0.93	neutral	0.53	deleterious	2	deleterious	0.85	deleterious	-1.8	low_impact	1.85	high_impact	2.74	high_impact	0.43	0.8	8.7	10.6	0.59	P	0.91	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10281	10281	C	A	MI.15443	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	223	75	L	M	Cta/Ata	-8.89	0	0	probably_damaging	0.98	neutral	0.24	neutral	0.89	neutral	-1.2	neutral	-1.74	medium_impact	2.06	0.79	neutral	0.52	neutral	3.67	23.30	deleterious	0.3	0.45	0.31	neutral	0.3	neutral	0.31	neutral	0.44	neutral	1	0.98	deleterious	0.13	neutral	1	deleterious	0.67	deleterious	-2.24	low_impact	-0.09	medium_impact	0.78	medium_impact	0.48	0.8	4.35	6.92	0.39	N	0.91	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10281	10281	C	G	MI.15444	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	223	75	L	V	Cta/Gta	-8.89	0	0	benign	0.18	neutral	0.54	neutral	0.95	neutral	-0.4	neutral	-2.31	medium_impact	2.56	0.76	neutral	0.44	neutral	1.48	13.22	neutral	0.27	0.45	0.41	neutral	0.34	neutral	0.6	disease	0.48	neutral	0	0.35	neutral	0.68	deleterious	-3	neutral	0.22	neutral	-0.12	medium_impact	0.23	medium_impact	1.24	medium_impact	0.52	0.8	4.35	6.92	0.3	N	0.89	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10282	10282	T	G	MI.15445	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	224	75	L	R	cTa/cGa	0.13	0	0	probably_damaging	0.98	neutral	0.35	neutral	0.82	neutral	-2.94	deleterious	-5.51	high_impact	4.01	0.67	neutral	0.25	damaging	4.12	23.80	deleterious	0.04	0.35	0.83	disease	0.79	disease	0.71	disease	0.67	disease	3	0.98	neutral	0.19	neutral	2	deleterious	0.86	deleterious	-2.24	low_impact	0.04	medium_impact	2.57	high_impact	0.19	0.8	4.35	6.92	0.34	N	1.00	polymorphism	1	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10282	10282	T	A	MI.15446	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	224	75	L	Q	cTa/cAa	0.13	0	0	probably_damaging	0.98	neutral	0.29	neutral	0.82	deleterious	-3.11	deleterious	-5.48	high_impact	3.66	0.72	neutral	0.29	neutral	4.00	23.60	deleterious	0.06	0.35	0.81	disease	0.69	disease	0.59	disease	0.65	disease	3	0.99	deleterious	0.16	neutral	2	deleterious	0.80	deleterious	-2.24	low_impact	-0.03	medium_impact	2.25	high_impact	0.21	0.8	4.35	6.92	0.34	N	0.97	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10282	10282	T	C	MI.15447	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	224	75	L	P	cTa/cCa	0.13	0	0	probably_damaging	0.98	neutral	0.38	neutral	0.81	deleterious	-3.53	deleterious	-6.37	medium_impact	2.77	0.62	neutral	0.25	damaging	3.84	23.40	deleterious	0.04	0.35	0.86	disease	0.78	disease	0.69	disease	0.66	disease	3	0.99	deleterious	0.2	neutral	1	deleterious	0.85	deleterious	-2.24	low_impact	0.07	medium_impact	1.43	medium_impact	0.20	0.8	4.35	6.92	0.25	N	0.99	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10284	10284	C	G	MI.15448	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	226	76	P	A	Cca/Gca	-12.37	0	0	probably_damaging	1	neutral	0.54	neutral	1.18	neutral	1.53	deleterious	-7.41	medium_impact	2.83	0.65	neutral	0.12	damaging	3.05	22.40	deleterious	0.19	0.45	0.29	neutral	0.44	neutral	0.55	disease	0.41	neutral	2	1	deleterious	0.27	neutral	1	deleterious	0.70	deleterious	-3.43	low_impact	0.23	medium_impact	1.49	medium_impact	0.60	0.8	NA	NA	0.34	N	0.81	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10284	10284	C	T	MI.15449	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	226	76	P	S	Cca/Tca	-12.37	0	0	probably_damaging	1	neutral	0.45	neutral	0.97	neutral	-0.57	deleterious	-7.41	medium_impact	3.42	0.65	neutral	0.11	damaging	3.84	23.40	deleterious	0.23	0.45	0.32	neutral	0.63	disease	0.64	disease	0.56	disease	1	1	deleterious	0.23	neutral	1	deleterious	0.72	deleterious	-3.43	low_impact	0.14	medium_impact	2.03	high_impact	0.14	0.8	NA	NA	0.32	N	0.95	polymorphism	1	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8413	8413	A	T	MI.1545	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	48	16	M	I	atA/atT	1.75	0	0	possibly_damaging	0.82	neutral	0.4	neutral	1.91	neutral	4.18	deleterious	-3.33	medium_impact	2.29	0.95	neutral	0.52	neutral	3.08	22.50	deleterious	0.55484047	0.85	0.45	neutral	0.31	neutral	0.73	disease	0.17	neutral	7	0.82	neutral	0.29	neutral	0	NA	0.57	deleterious	-1.38	low_impact	0.19	medium_impact	0.87	medium_impact	0.63	0.85	NA	NA	0.5	N	0.64	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10284	10284	C	A	MI.15450	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	226	76	P	T	Cca/Aca	-12.37	0	0	probably_damaging	1	neutral	0.41	neutral	0.98	neutral	-0.39	deleterious	-7.41	medium_impact	3.06	0.61	neutral	0.07	damaging	3.65	23.20	deleterious	0.14	0.4	0.37	neutral	0.59	disease	0.54	disease	0.34	neutral	3	1	deleterious	0.21	neutral	1	deleterious	0.72	deleterious	-3.43	low_impact	0.1	medium_impact	1.7	medium_impact	0.58	0.8	NA	NA	0.29	N	0.97	polymorphism	1	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10285	10285	C	T	MI.15451	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	227	76	P	L	cCa/cTa	4.52	0.99	0	probably_damaging	1	neutral	0.96	neutral	1.07	neutral	0.79	deleterious	-9.19	medium_impact	2.42	0.61	neutral	0.06	damaging	4.32	24.00	deleterious	0.13	0.4	0.4	neutral	0.76	disease	0.62	disease	0.58	disease	2	1	deleterious	0.48	deleterious	1	deleterious	0.74	deleterious	-3.43	low_impact	0.96	medium_impact	1.11	medium_impact	0.51	0.8	NA	NA	0.36	N	0.97	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10285	10285	C	A	MI.15452	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	227	76	P	Q	cCa/cAa	4.52	0.99	0	probably_damaging	1	neutral	0.28	neutral	0.93	neutral	-1.8	deleterious	-7.39	high_impact	3.87	0.62	neutral	0.06	damaging	4.18	23.80	deleterious	0.11	0.4	0.49	neutral	0.76	disease	0.68	disease	0.65	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.74	deleterious	-3.43	low_impact	-0.04	medium_impact	2.44	high_impact	0.42	0.8	NA	NA	0.57	P	0.90	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10285	10285	C	G	MI.15453	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	227	76	P	R	cCa/cGa	4.52	0.99	0	probably_damaging	1	neutral	0.36	neutral	0.93	neutral	-1.7	deleterious	-8.36	high_impact	4.22	0.61	neutral	0.06	damaging	3.51	23.10	deleterious	0.07	0.35	0.49	neutral	0.79	disease	0.77	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.05	medium_impact	2.76	high_impact	0.33	0.8	NA	NA	0.65	P	0.73	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10287	10287	T	C	MI.15454	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	229	77	W	R	Tga/Cga	-6.12	0	0	probably_damaging	0.98	neutral	0.35	neutral	1.01	deleterious	-3.5	deleterious	-13.07	high_impact	4.15	0.58	damaging	0.03	damaging	3.54	23.10	deleterious	0.07	0.35	0.62	disease	0.86	disease	0.77	disease	0.75	disease	5	0.98	deleterious	0.19	neutral	2	deleterious	0.81	deleterious	-2.24	low_impact	0.04	medium_impact	2.7	high_impact	0.13	0.8	2.61	6.92	0.47	N	0.97	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10287	10287	T	G	MI.15455	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	229	77	W	G	Tga/Gga	-6.12	0	0	probably_damaging	0.96	neutral	0.34	neutral	1.03	deleterious	-3.61	deleterious	-11.87	high_impact	4.15	0.58	damaging	0.06	damaging	3.91	23.50	deleterious	0.09	0.35	0.66	disease	0.74	disease	0.73	disease	0.71	disease	4	0.96	neutral	0.19	neutral	2	deleterious	0.74	deleterious	-1.96	low_impact	0.03	medium_impact	2.7	high_impact	0.11	0.8	2.61	6.92	0.41	N	0.97	polymorphism	1	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10288	10288	G	T	MI.15456	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	230	77	W	L	tGa/tTa	7.53	1	0	possibly_damaging	0.63	neutral	0.82	neutral	1.21	neutral	-1.47	deleterious	-12.04	medium_impact	2.52	0.52	damaging	0.04	damaging	4.22	23.90	deleterious	0.12	0.4	0.23	neutral	0.76	disease	0.69	disease	0.52	disease	0	0.56	neutral	0.6	deleterious	0	NA	0.59	deleterious	-0.93	medium_impact	0.56	medium_impact	1.2	medium_impact	0.10	0.8	2.61	6.92	0.49	N	0.97	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10288	10288	G	C	MI.15457	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	230	77	W	S	tGa/tCa	7.53	1	0	probably_damaging	0.96	neutral	0.46	neutral	1.06	neutral	-2.61	deleterious	-12.99	medium_impact	2.76	0.55	damaging	0.06	damaging	4.01	23.60	deleterious	0.1	0.4	0.54	disease	0.8	disease	0.71	disease	0.56	disease	1	0.95	neutral	0.25	neutral	1	deleterious	0.77	deleterious	-1.96	low_impact	0.15	medium_impact	1.42	medium_impact	0.13	0.8	2.61	6.92	0.45	N	0.95	disease_causing	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10289	10289	A	C	MI.15458	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	231	77	W	C	tgA/tgC	9.15	1	0	probably_damaging	0.99	neutral	0.18	neutral	1	deleterious	-4.27	deleterious	-12.15	high_impact	4.15	0.6	damaging	0.03	damaging	4.02	23.60	deleterious	0.08	0.35	0.74	disease	0.81	disease	0.76	disease	0.73	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-2.52	low_impact	-0.18	medium_impact	2.7	high_impact	0.15	0.8	2.61	6.92	0.6	P	0.98	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10289	10289	A	T	MI.15459	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	231	77	W	C	tgA/tgT	9.15	1	0	probably_damaging	0.99	neutral	0.18	neutral	1	deleterious	-4.27	deleterious	-12.15	high_impact	4.15	0.6	damaging	0.03	damaging	4.10	23.70	deleterious	0.08	0.35	0.74	disease	0.81	disease	0.76	disease	0.73	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-2.52	low_impact	-0.18	medium_impact	2.7	high_impact	0.15	0.8	2.61	6.92	0.61	P	0.98	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8413	8413	A	C	MI.1546	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	48	16	M	I	atA/atC	1.75	0	0	possibly_damaging	0.82	neutral	0.4	neutral	1.91	neutral	4.18	deleterious	-3.33	medium_impact	2.29	0.95	neutral	0.52	neutral	3.01	22.30	deleterious	0.55484047	0.85	0.45	neutral	0.31	neutral	0.73	disease	0.17	neutral	7	0.82	neutral	0.29	neutral	0	NA	0.57	deleterious	-1.38	low_impact	0.19	medium_impact	0.87	medium_impact	0.63	0.85	NA	NA	0.49	N	0.64	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10290	10290	G	T	MI.15460	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	232	78	A	S	Gcc/Tcc	0.13	0.98	0	possibly_damaging	0.86	neutral	0.43	neutral	1	neutral	-2.26	neutral	-2.35	low_impact	1.9	0.7	neutral	0.56	neutral	3.43	23.00	deleterious	0.28	0.45	0.32	neutral	0.44	neutral	0.21	neutral	0.46	neutral	1	0.85	neutral	0.29	neutral	-3	neutral	0.67	deleterious	-1.43	low_impact	0.12	medium_impact	0.63	medium_impact	0.43	0.8	6.96	7.87	0.55	N	0.98	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10290	10290	G	A	MI.15461	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	232	78	A	T	Gcc/Acc	0.13	0.98	0	probably_damaging	0.95	neutral	0.4	neutral	0.97	neutral	-2.85	deleterious	-3.35	medium_impact	2.41	0.73	neutral	0.54	neutral	4.09	23.70	deleterious	0.19	0.45	0.35	neutral	0.51	disease	0.25	neutral	0.34	neutral	3	0.95	neutral	0.23	neutral	1	deleterious	0.69	deleterious	-1.87	low_impact	0.09	medium_impact	1.1	medium_impact	0.71	0.85	6.96	7.87	0.51	N	0.93	polymorphism	1	0.52	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10290	10290	G	C	MI.15462	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	232	78	A	P	Gcc/Ccc	0.13	0.98	0	probably_damaging	0.98	neutral	0.23	neutral	0.89	deleterious	-4.67	deleterious	-4.38	medium_impact	2.75	0.59	damaging	0.22	damaging	3.82	23.40	deleterious	0.06	0.35	0.59	disease	0.84	disease	0.67	disease	0.71	disease	4	0.99	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-2.24	low_impact	-0.1	medium_impact	1.41	medium_impact	0.33	0.8	6.96	7.87	0.47	N	0.96	polymorphism	1	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10291	10291	C	T	MI.15463	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	233	78	A	V	gCc/gTc	3.6	1	0	probably_damaging	0.95	neutral	0.53	neutral	1.02	neutral	-2.26	deleterious	-3.53	medium_impact	2.65	0.8	neutral	0.46	neutral	4.33	24.00	deleterious	0.17	0.45	0.3	neutral	0.59	disease	0.54	disease	0.5	neutral	0	0.95	neutral	0.29	neutral	1	deleterious	0.68	deleterious	-1.87	low_impact	0.22	medium_impact	1.32	medium_impact	0.66	0.8	6.96	7.87	0.45	N	0.79	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10291	10291	C	A	MI.15464	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	233	78	A	D	gCc/gAc	3.6	1	0	probably_damaging	0.96	neutral	0.21	neutral	0.95	deleterious	-4.05	deleterious	-5.11	high_impact	3.59	0.65	neutral	0.3	neutral	4.58	24.40	deleterious	0.04	0.35	0.56	disease	0.81	disease	0.68	disease	0.68	disease	4	0.97	neutral	0.13	neutral	2	deleterious	0.77	deleterious	-1.96	low_impact	-0.13	medium_impact	2.18	high_impact	0.23	0.8	6.96	7.87	0.57	P	0.96	polymorphism	1	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10291	10291	C	G	MI.15465	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	233	78	A	G	gCc/gGc	3.6	1	0	benign	0.06	neutral	0.33	neutral	0.91	deleterious	-3.84	deleterious	-2.7	medium_impact	2.79	0.74	neutral	0.58	neutral	0.34	6.08	deleterious	0.26	0.45	0.28	neutral	0.17	neutral	0.23	neutral	0.28	neutral	4	0.64	neutral	0.64	deleterious	-3	neutral	0.16	neutral	0.36	medium_impact	0.02	medium_impact	1.45	medium_impact	0.51	0.8	6.96	7.87	0.67	P	0.85	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10293	10293	C	G	MI.15466	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	235	79	L	V	Cta/Gta	-10.98	0	0	possibly_damaging	0.61	neutral	0.5	neutral	0.96	neutral	1.22	neutral	-0.08	neutral_impact	0.8	0.78	neutral	0.97	neutral	1.52	13.40	neutral	0.3	0.45	0.15	neutral	0.16	neutral	0.17	neutral	0.3	neutral	4	0.59	neutral	0.45	neutral	-3	neutral	0.49	deleterious	-0.89	medium_impact	0.19	medium_impact	-0.38	medium_impact	0.31	0.8	26.96	12.02	0.47	N	0.22	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10293	10293	C	A	MI.15467	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	235	79	L	M	Cta/Ata	-10.98	0	0	probably_damaging	0.97	neutral	0.29	neutral	0.87	neutral	-1.56	neutral	0.14	neutral_impact	0.66	0.78	neutral	0.98	neutral	2.18	17.37	deleterious	0.24	0.45	0.18	neutral	0.11	neutral	0.15	neutral	0.29	neutral	4	0.97	neutral	0.16	neutral	-2	neutral	0.61	deleterious	-2.08	low_impact	-0.03	medium_impact	-0.5	medium_impact	0.40	0.8	26.96	12.02	0.56	P	0.43	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10294	10294	T	C	MI.15468	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	236	79	L	P	cTa/cCa	-0.57	0	0	probably_damaging	0.98	neutral	0.25	neutral	0.81	deleterious	-3.2	neutral	-2.09	medium_impact	3.1	0.67	neutral	0.4	neutral	2.59	20.10	deleterious	0.03	0.35	0.4	neutral	0.73	disease	0.56	disease	0.68	disease	4	0.98	deleterious	0.14	neutral	1	deleterious	0.74	deleterious	-2.24	low_impact	-0.08	medium_impact	1.73	medium_impact	0.19	0.8	26.96	12.02	0.39	N	0.81	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10294	10294	T	G	MI.15469	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	236	79	L	R	cTa/cGa	-0.57	0	0	probably_damaging	0.97	neutral	0.34	neutral	0.82	neutral	-2.62	neutral	-2.17	medium_impact	3.44	0.72	neutral	0.51	neutral	2.65	20.50	deleterious	0.02	0.35	0.27	neutral	0.69	disease	0.53	disease	0.6	disease	2	0.97	neutral	0.19	neutral	1	deleterious	0.71	deleterious	-2.08	low_impact	0.03	medium_impact	2.05	high_impact	0.12	0.8	26.96	12.02	0.41	N	0.65	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8414	8414	C	T	MI.1547	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	49	17	L	F	Ctc/Ttc	-2.42	0	0.46	probably_damaging	0.99	neutral	0.31	neutral	1.71	neutral	-2.75	neutral	-1.98	low_impact	1.05	1	neutral	0.79	neutral	2.42	18.98	deleterious	0.51005936	0.85	0.27	neutral	0.15	neutral	0.37	neutral	0.06	neutral	9	0.99	deleterious	0.16	neutral	-2	neutral	0.71	deleterious	-2.65	low_impact	0.1	medium_impact	-0.2	medium_impact	0.65	0.85	NA	NA	0.58	P	0.12	polymorphism	1	0.03	rs28358884	.	.	.	.	.	.	.	23.41	C8414T	Longevity	+	-	Reported	1	N	P	N,P	neutral
chrM	10294	10294	T	A	MI.15470	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	236	79	L	Q	cTa/cAa	-0.57	0	0	probably_damaging	0.98	neutral	0.31	neutral	0.82	neutral	-2.7	neutral	-1.61	medium_impact	2.63	0.77	neutral	0.58	neutral	2.59	20.10	deleterious	0.05	0.35	0.26	neutral	0.45	neutral	0.38	neutral	0.47	neutral	1	0.98	deleterious	0.17	neutral	1	deleterious	0.65	deleterious	-2.24	low_impact	0	medium_impact	1.3	medium_impact	0.10	0.8	26.96	12.02	0.4	N	0.63	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10296	10296	C	A	MI.15471	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	238	80	Q	K	Caa/Aaa	-5.66	0	0	possibly_damaging	0.85	neutral	0.29	neutral	2.01	neutral	0.24	deleterious	-3.53	low_impact	1.86	0.74	neutral	0.08	damaging	3.98	23.60	deleterious	0.25	0.45	0.16	neutral	0.61	disease	0.36	neutral	0.35	neutral	3	0.88	neutral	0.22	neutral	-3	neutral	0.64	deleterious	-1.4	low_impact	-0.03	medium_impact	0.6	medium_impact	0.31	0.8	5.22	11.64	0.26	N	0.96	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10296	10296	C	G	MI.15472	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	238	80	Q	E	Caa/Gaa	-5.66	0	0	possibly_damaging	0.89	neutral	0.27	neutral	1.98	neutral	0.12	deleterious	-2.62	medium_impact	2.38	0.73	neutral	0.11	damaging	3.14	22.60	deleterious	0.36	0.5	0.25	neutral	0.55	disease	0.38	neutral	0.44	neutral	1	0.91	neutral	0.19	neutral	0	NA	0.65	deleterious	-1.54	low_impact	-0.05	medium_impact	1.07	medium_impact	0.58	0.8	5.22	11.64	0.3	N	0.93	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10297	10297	A	C	MI.15473	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	239	80	Q	P	cAa/cCa	1.98	0.95	0	benign	0.12	neutral	0.22	neutral	1.88	neutral	-1.96	deleterious	-4.86	medium_impact	2.85	0.65	neutral	0.09	damaging	3.13	22.60	deleterious	0.08	0.35	0.55	disease	0.78	disease	0.7	disease	0.68	disease	4	0.75	neutral	0.55	deleterious	-3	neutral	0.30	neutral	0.06	medium_impact	-0.12	medium_impact	1.5	medium_impact	0.31	0.8	5.22	11.64	0.38	N	0.96	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10297	10297	A	T	MI.15474	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	239	80	Q	L	cAa/cTa	1.98	0.95	0	probably_damaging	0.93	neutral	0.67	neutral	1.92	neutral	-1.27	deleterious	-6.31	medium_impact	2.19	0.83	neutral	0.21	damaging	3.60	23.20	deleterious	0.13	0.4	0.39	neutral	0.72	disease	0.43	neutral	0.47	neutral	1	0.91	neutral	0.37	neutral	1	deleterious	0.71	deleterious	-1.73	low_impact	0.36	medium_impact	0.9	medium_impact	0.17	0.8	5.22	11.64	0.3	N	0.97	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10297	10297	A	G	MI.15475	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	239	80	Q	R	cAa/cGa	1.98	0.95	0	probably_damaging	0.95	neutral	0.34	neutral	1.93	neutral	-0.48	deleterious	-3.54	medium_impact	3.48	0.67	neutral	0.09	damaging	3.24	22.80	deleterious	0.28	0.45	0.25	neutral	0.73	disease	0.6	disease	0.64	disease	3	0.95	neutral	0.2	neutral	1	deleterious	0.73	deleterious	-1.87	low_impact	0.03	medium_impact	2.08	high_impact	0.18	0.8	5.22	11.64	0.42	N	0.85	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10298	10298	A	C	MI.15476	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	240	80	Q	H	caA/caC	6.84	0.99	0	probably_damaging	0.99	neutral	0.54	neutral	1.89	neutral	-1.52	deleterious	-4.18	low_impact	1.68	0.83	neutral	0.81	neutral	3.34	22.90	deleterious	0.24	0.45	0.48	neutral	0.58	disease	0.34	neutral	0.38	neutral	2	0.98	deleterious	0.28	neutral	-2	neutral	0.73	deleterious	-2.52	low_impact	0.23	medium_impact	0.43	medium_impact	0.39	0.8	5.22	11.64	0.51	N	0.93	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10298	10298	A	T	MI.15477	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	240	80	Q	H	caA/caT	6.84	0.99	0	probably_damaging	0.99	neutral	0.54	neutral	1.89	neutral	-1.52	deleterious	-4.18	low_impact	1.68	0.83	neutral	0.81	neutral	3.49	23.10	deleterious	0.24	0.45	0.48	neutral	0.58	disease	0.34	neutral	0.38	neutral	2	0.98	deleterious	0.28	neutral	-2	neutral	0.73	deleterious	-2.52	low_impact	0.23	medium_impact	0.43	medium_impact	0.39	0.8	5.22	11.64	0.51	N	0.93	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10299	10299	A	C	MI.15478	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	241	81	T	P	Aca/Cca	1.52	0.72	0	probably_damaging	0.99	neutral	0.21	neutral	0.93	neutral	-1.9	deleterious	-2.89	medium_impact	2.19	0.63	neutral	0.09	damaging	3.44	23.00	deleterious	0.09	0.35	0.53	disease	0.68	disease	0.62	disease	0.69	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.72	deleterious	-2.52	low_impact	-0.13	medium_impact	0.9	medium_impact	0.25	0.8	8.7	9.15	0.31	N	0.99	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10299	10299	A	G	MI.15479	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	241	81	T	A	Aca/Gca	1.52	0.72	0	possibly_damaging	0.9	neutral	0.52	neutral	1.03	neutral	0.37	neutral	-1.54	low_impact	1.43	0.78	neutral	0.82	neutral	2.26	17.88	deleterious	0.36	0.5	0.24	neutral	0.22	neutral	0.44	neutral	0.42	neutral	2	0.89	neutral	0.31	neutral	-3	neutral	0.60	deleterious	-1.58	low_impact	0.21	medium_impact	0.2	medium_impact	0.24	0.8	8.7	9.15	0.35	N	0.86	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8414	8414	C	G	MI.1548	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	49	17	L	V	Ctc/Gtc	-2.42	0	0.46	probably_damaging	0.97	neutral	0.15	neutral	1.75	neutral	-1.92	neutral	-0.69	low_impact	1	1	neutral	0.93	neutral	2.05	16.51	deleterious	0.67403744	0.85	0.33	neutral	0.22	neutral	0.32	neutral	0.19	neutral	6	0.99	deleterious	0.09	neutral	-2	neutral	0.71	deleterious	-2.19	low_impact	-0.13	medium_impact	-0.24	medium_impact	0.62	0.85	NA	NA	0.59	P	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10299	10299	A	T	MI.15480	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	241	81	T	S	Aca/Tca	1.52	0.72	0	possibly_damaging	0.82	neutral	0.42	neutral	1.02	neutral	0.28	neutral	-0.83	neutral_impact	0.78	0.76	neutral	0.96	neutral	1.62	13.95	neutral	0.44	0.55	0.3	neutral	0.19	neutral	0.27	neutral	0.36	neutral	3	0.82	neutral	0.3	neutral	-3	neutral	0.58	deleterious	-1.31	low_impact	0.11	medium_impact	-0.39	medium_impact	0.38	0.8	8.7	9.15	0.36	N	0.47	polymorphism	1	0.17	rs878918474	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10300	10300	C	A	MI.15481	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	242	81	T	K	aCa/aAa	-1.03	0	0	probably_damaging	0.95	neutral	0.31	neutral	1.05	neutral	0.58	neutral	-2.4	low_impact	1.92	0.69	neutral	0.12	damaging	4.48	24.20	deleterious	0.16	0.45	0.33	neutral	0.54	disease	0.5	neutral	0.5	neutral	0	0.96	neutral	0.18	neutral	-2	neutral	0.66	deleterious	-1.87	low_impact	0	medium_impact	0.65	medium_impact	0.42	0.8	8.7	9.15	0.29	N	0.97	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10300	10300	C	T	MI.15482	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	242	81	T	M	aCa/aTa	-1.03	0	0	probably_damaging	0.99	neutral	0.23	neutral	0.94	neutral	-1.68	neutral	-1.22	neutral_impact	0.7	0.78	neutral	0.93	neutral	2.75	21.10	deleterious	0.23	0.45	0.36	neutral	0.26	neutral	0.34	neutral	0.45	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.64	deleterious	-2.52	low_impact	-0.1	medium_impact	-0.47	medium_impact	0.40	0.8	8.7	9.15	0.38	N	0.80	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10302	10302	A	T	MI.15483	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	244	82	T	S	Act/Tct	-11.47	0	0	benign	0.17	neutral	0.48	neutral	1.05	neutral	0.5	neutral	0.02	neutral_impact	-0.41	0.74	neutral	0.98	neutral	-0.78	0.05	neutral	0.4	0.5	0.1	neutral	0.09	neutral	0.2	neutral	0.26	neutral	5	0.43	neutral	0.66	deleterious	-6	neutral	0.11	neutral	-0.1	medium_impact	0.17	medium_impact	-1.48	low_impact	0.50	0.8	20.87	10.61	0.45	N	0.09	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10302	10302	A	G	MI.15484	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	244	82	T	A	Act/Gct	-11.47	0	0	benign	0	neutral	0.51	neutral	1.02	neutral	0.32	neutral	-1.43	low_impact	0.88	0.86	neutral	0.96	neutral	-0.52	0.20	neutral	0.33	0.5	0.13	neutral	0.16	neutral	0.35	neutral	0.26	neutral	5	0.48	neutral	0.76	deleterious	-6	neutral	0.07	neutral	1.99	medium_impact	0.2	medium_impact	-0.3	medium_impact	0.19	0.8	20.87	10.61	0.39	N	0.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10302	10302	A	C	MI.15485	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	244	82	T	P	Act/Cct	-11.47	0	0	possibly_damaging	0.53	neutral	0.23	neutral	0.94	neutral	-1.35	neutral	-1.36	neutral_impact	0.08	0.77	neutral	0.98	neutral	-0.27	0.76	neutral	0.1	0.4	0.27	neutral	0.38	neutral	0.37	neutral	0.44	neutral	1	0.76	neutral	0.35	neutral	-3	neutral	0.38	neutral	-0.76	medium_impact	-0.1	medium_impact	-1.04	low_impact	0.29	0.8	20.87	10.61	0.43	N	0.10	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10303	10303	C	A	MI.15486	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	245	82	T	N	aCt/aAt	-2.94	0	0	benign	0.03	neutral	0.36	neutral	1.01	neutral	-0.02	neutral	0.62	neutral_impact	-0.58	0.78	neutral	0.99	neutral	-0.34	0.53	neutral	0.34	0.5	0.12	neutral	0.22	neutral	0.22	neutral	0.39	neutral	2	0.62	neutral	0.67	deleterious	-6	neutral	0.08	neutral	0.65	medium_impact	0.05	medium_impact	-1.64	low_impact	0.42	0.8	20.87	10.61	0.35	N	0.14	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10303	10303	C	T	MI.15487	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	245	82	T	I	aCt/aTt	-2.94	0	0	benign	0.37	neutral	0.41	neutral	0.95	neutral	-1.53	neutral	-2.33	neutral_impact	0.78	0.8	neutral	0.9	neutral	0.39	6.49	deleterious	0.17	0.45	0.27	neutral	0.32	neutral	0.37	neutral	0.44	neutral	1	0.52	neutral	0.52	deleterious	-6	neutral	0.33	neutral	-0.51	medium_impact	0.1	medium_impact	-0.39	medium_impact	0.48	0.8	20.87	10.61	0.31	N	0.24	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10303	10303	C	G	MI.15488	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	245	82	T	S	aCt/aGt	-2.94	0	0	benign	0.17	neutral	0.48	neutral	1.05	neutral	0.5	neutral	0.02	neutral_impact	-0.41	0.74	neutral	0.98	neutral	-0.64	0.10	neutral	0.4	0.5	0.1	neutral	0.09	neutral	0.2	neutral	0.26	neutral	5	0.43	neutral	0.66	deleterious	-6	neutral	0.11	neutral	-0.1	medium_impact	0.17	medium_impact	-1.48	low_impact	0.50	0.8	20.87	10.61	0.44	N	0.09	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10305	10305	A	G	MI.15489	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	247	83	N	D	Aac/Gac	-11.47	0	0	possibly_damaging	0.86	neutral	0.21	neutral	0.94	neutral	-0.28	deleterious	-2.61	medium_impact	1.96	0.77	neutral	0.87	neutral	2.17	17.31	deleterious	0.66	0.7	0.25	neutral	0.33	neutral	0.44	neutral	0.44	neutral	1	0.91	neutral	0.18	neutral	0	NA	0.55	deleterious	-1.43	low_impact	-0.13	medium_impact	0.69	medium_impact	0.21	0.8	4.35	9.01	0.46	N	0.80	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8414	8414	C	A	MI.1549	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	49	17	L	I	Ctc/Atc	-2.42	0	0.46	probably_damaging	0.97	neutral	0.35	neutral	1.82	neutral	-1.14	neutral	0.13	neutral_impact	-0.56	0.99	neutral	0.93	neutral	2.33	18.39	deleterious	0.67403744	0.85	0.16	neutral	0.17	neutral	0.22	neutral	0.09	neutral	8	0.97	neutral	0.19	neutral	-2	neutral	0.68	deleterious	-2.19	low_impact	0.14	medium_impact	-1.58	low_impact	0.57	0.85	NA	NA	0.51	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10305	10305	A	C	MI.15490	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	247	83	N	H	Aac/Cac	-11.47	0	0	probably_damaging	0.98	neutral	0.54	neutral	0.92	neutral	-1.67	deleterious	-3.35	medium_impact	2.31	0.77	neutral	0.56	neutral	1.95	15.92	deleterious	0.44	0.55	0.31	neutral	0.37	neutral	0.45	neutral	0.45	neutral	1	0.98	deleterious	0.28	neutral	1	deleterious	0.64	deleterious	-2.24	low_impact	0.23	medium_impact	1.01	medium_impact	0.05	0.8	4.35	9.01	0.3	N	0.55	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10305	10305	A	T	MI.15491	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	247	83	N	Y	Aac/Tac	-11.47	0	0	probably_damaging	0.98	neutral	1	neutral	0.92	neutral	-2.39	deleterious	-5.42	medium_impact	2.4	0.86	neutral	0.66	neutral	3.65	23.20	deleterious	0.14	0.4	0.52	disease	0.44	neutral	0.47	neutral	0.38	neutral	2	0.98	deleterious	0.51	deleterious	1	deleterious	0.68	deleterious	-2.24	low_impact	1.85	high_impact	1.09	medium_impact	0.11	0.8	4.35	9.01	0.24	N	0.94	polymorphism	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10306	10306	A	C	MI.15492	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	248	83	N	T	aAc/aCc	-0.17	0	0	possibly_damaging	0.81	neutral	0.4	neutral	0.98	neutral	-0.69	deleterious	-3.14	low_impact	1.69	0.76	neutral	0.94	neutral	0.46	7.13	deleterious	0.39	0.5	0.23	neutral	0.21	neutral	0.36	neutral	0.37	neutral	3	0.82	neutral	0.3	neutral	-3	neutral	0.50	deleterious	-1.29	low_impact	0.09	medium_impact	0.44	medium_impact	0.13	0.8	4.35	9.01	0.42	N	0.70	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10306	10306	A	T	MI.15493	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	248	83	N	I	aAc/aTc	-0.17	0	0	probably_damaging	0.98	neutral	0.4	neutral	0.97	neutral	-2.32	deleterious	-5.96	medium_impact	2.63	0.8	neutral	0.13	damaging	3.88	23.50	deleterious	0.14	0.4	0.45	neutral	0.6	disease	0.52	disease	0.57	disease	1	0.98	neutral	0.21	neutral	1	deleterious	0.68	deleterious	-2.24	low_impact	0.09	medium_impact	1.3	medium_impact	0.10	0.8	4.35	9.01	0.24	N	0.96	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10306	10306	A	G	MI.15494	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	248	83	N	S	aAc/aGc	-0.17	0	0	benign	0.18	neutral	0.42	neutral	1.01	neutral	0.05	neutral	-2.29	low_impact	1.2	0.75	neutral	0.95	neutral	-0.27	0.78	neutral	0.58	0.65	0.19	neutral	0.1	neutral	0.35	neutral	0.29	neutral	4	0.5	neutral	0.62	deleterious	-6	neutral	0.13	neutral	-0.12	medium_impact	0.11	medium_impact	-0.01	medium_impact	0.13	0.8	4.35	9.01	0.46	N	0.72	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10307	10307	C	A	MI.15495	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	249	83	N	K	aaC/aaA	-0.17	0	0	possibly_damaging	0.86	neutral	0.3	neutral	0.98	neutral	0.3	deleterious	-3.33	medium_impact	1.98	0.82	neutral	0.67	neutral	3.01	22.30	deleterious	0.52	0.6	0.16	neutral	0.44	neutral	0.46	neutral	0.45	neutral	1	0.88	neutral	0.22	neutral	0	NA	0.57	deleterious	-1.43	low_impact	-0.01	medium_impact	0.71	medium_impact	0.29	0.8	4.35	9.01	0.35	N	0.33	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10307	10307	C	G	MI.15496	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	249	83	N	K	aaC/aaG	-0.17	0	0	possibly_damaging	0.86	neutral	0.3	neutral	0.98	neutral	0.3	deleterious	-3.33	medium_impact	1.98	0.82	neutral	0.67	neutral	2.54	19.73	deleterious	0.52	0.6	0.16	neutral	0.44	neutral	0.46	neutral	0.45	neutral	1	0.88	neutral	0.22	neutral	0	NA	0.57	deleterious	-1.43	low_impact	-0.01	medium_impact	0.71	medium_impact	0.29	0.8	4.35	9.01	0.35	N	0.33	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10308	10308	C	A	MI.15497	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	250	84	L	M	Ctg/Atg	-9.85	0	0	probably_damaging	0.97	neutral	0.26	neutral	0.91	neutral	-2.53	neutral	-0.68	low_impact	1.4	0.83	neutral	0.76	neutral	2.61	20.30	deleterious	0.27	0.45	0.35	neutral	0.29	neutral	0.41	neutral	0.45	neutral	1	0.98	neutral	0.15	neutral	-2	neutral	0.65	deleterious	-2.08	low_impact	-0.06	medium_impact	0.18	medium_impact	0.54	0.8	6.96	8.79	0.42	N	0.47	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10308	10308	C	G	MI.15498	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	250	84	L	V	Ctg/Gtg	-9.85	0	0	possibly_damaging	0.61	neutral	0.51	neutral	0.95	neutral	-1.44	neutral	-1.02	medium_impact	2.3	0.84	neutral	0.67	neutral	0.45	7.00	deleterious	0.28	0.45	0.19	neutral	0.32	neutral	0.35	neutral	0.43	neutral	1	0.59	neutral	0.45	neutral	0	NA	0.47	deleterious	-0.89	medium_impact	0.2	medium_impact	1	medium_impact	0.34	0.8	6.96	8.79	0.35	N	0.34	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10309	10309	T	G	MI.15499	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	251	84	L	R	cTg/cGg	-0.17	0	0	probably_damaging	0.98	neutral	0.34	neutral	0.9	deleterious	-3.74	deleterious	-3.29	medium_impact	3.36	0.67	neutral	0.09	damaging	4.08	23.70	deleterious	0.04	0.35	0.43	neutral	0.82	disease	0.71	disease	0.79	disease	6	0.98	neutral	0.18	neutral	1	deleterious	0.78	deleterious	-2.24	low_impact	0.03	medium_impact	1.97	medium_impact	0.15	0.8	6.96	8.79	0.29	N	0.86	polymorphism	1	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8598	8598	T	A	MI.155	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	72	24	I	M	atT/atA	3.83	0.43	0	probably_damaging	1	neutral	0.35	neutral	3.96	neutral	-2.76	neutral	-1.44	neutral_impact	-0.32	0.87	neutral	0.96	neutral	2.04	16.44	deleterious	0.5	0.65	0.56	disease	0.13	neutral	0.27	neutral	0.29	neutral	4	1	deleterious	0.18	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.14	medium_impact	-1.37	low_impact	0.70	0.9	18.14	17.22	0.46	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8415	8415	T	C	MI.1550	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	50	17	L	P	cTc/cCc	-0.1	0	0	probably_damaging	1	deleterious	0.03	neutral	1.66	deleterious	-5.12	deleterious	-5.4	medium_impact	2.44	0.99	neutral	0.38	neutral	3.79	23.40	deleterious	0.22335685	0.85	0.81	disease	0.62	disease	0.68	disease	0.62	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-0.56	medium_impact	0.99	medium_impact	0.63	0.85	NA	NA	0.5	N	0.75	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10309	10309	T	C	MI.15500	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	251	84	L	P	cTg/cCg	-0.17	0	0	benign	0.17	neutral	0.24	neutral	0.89	deleterious	-3.85	neutral	-2.29	neutral_impact	0.78	0.74	neutral	0.87	neutral	0.68	8.67	deleterious	0.04	0.35	0.16	neutral	0.09	neutral	0.5	neutral	0.22	neutral	6	0.72	neutral	0.54	deleterious	-6	neutral	0.17	neutral	-0.1	medium_impact	-0.09	medium_impact	-0.39	medium_impact	0.26	0.8	6.96	8.79	0.47	N	0.54	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10309	10309	T	A	MI.15501	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	251	84	L	Q	cTg/cAg	-0.17	0	0	probably_damaging	0.98	neutral	0.29	neutral	0.9	deleterious	-3.9	deleterious	-3.06	medium_impact	2.87	0.74	neutral	0.16	damaging	3.08	22.50	deleterious	0.06	0.35	0.44	neutral	0.61	disease	0.48	neutral	0.49	neutral	0	0.99	deleterious	0.16	neutral	1	deleterious	0.72	deleterious	-2.24	low_impact	-0.03	medium_impact	1.52	medium_impact	0.23	0.8	6.96	8.79	0.34	N	0.81	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10311	10311	C	A	MI.15502	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	253	85	P	T	Cca/Aca	-11.01	0	0	benign	0.19	neutral	0.41	neutral	1.07	neutral	1.67	neutral	1.46	neutral_impact	-0.64	0.79	neutral	0.98	neutral	-0.96	0.02	neutral	0.23	0.45	0.09	neutral	0.06	neutral	0.28	neutral	0.23	neutral	5	0.51	neutral	0.61	deleterious	-6	neutral	0.12	neutral	-0.15	medium_impact	0.1	medium_impact	-1.7	low_impact	0.59	0.8	20	12.34	0.39	N	0.13	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10311	10311	C	T	MI.15503	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	253	85	P	S	Cca/Tca	-11.01	0	0	benign	0.01	neutral	0.41	neutral	1.05	neutral	1.66	neutral	1.38	neutral_impact	-0.44	0.86	neutral	0.99	neutral	-0.13	1.50	neutral	0.31	0.45	0.1	neutral	0.14	neutral	0.31	neutral	0.26	neutral	5	0.58	neutral	0.7	deleterious	-6	neutral	0.07	neutral	1.09	medium_impact	0.1	medium_impact	-1.51	low_impact	0.19	0.8	20	12.34	0.35	N	0.25	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10311	10311	C	G	MI.15504	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	253	85	P	A	Cca/Gca	-11.01	0	0	benign	0.08	neutral	0.5	neutral	1.09	neutral	1.98	neutral	0.2	low_impact	0.92	0.79	neutral	0.83	neutral	-0.77	0.05	neutral	0.23	0.45	0.12	neutral	0.11	neutral	0.41	neutral	0.3	neutral	4	0.43	neutral	0.71	deleterious	-6	neutral	0.10	neutral	0.24	medium_impact	0.19	medium_impact	-0.27	medium_impact	0.59	0.8	20	12.34	0.39	N	0.45	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10312	10312	C	A	MI.15505	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	254	85	P	Q	cCa/cAa	-0.17	0	0	benign	0.04	neutral	0.3	neutral	1.01	neutral	0.53	neutral	0.64	low_impact	1.2	0.81	neutral	0.85	neutral	0.66	8.53	deleterious	0.16	0.45	0.15	neutral	0.22	neutral	0.39	neutral	0.4	neutral	2	0.68	neutral	0.63	deleterious	-6	neutral	0.08	neutral	0.53	medium_impact	-0.01	medium_impact	-0.01	medium_impact	0.39	0.8	20	12.34	0.39	N	0.49	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10312	10312	C	T	MI.15506	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	254	85	P	L	cCa/cTa	-0.17	0	0	benign	0.01	neutral	0.66	neutral	1.23	neutral	3.21	neutral	-0.14	neutral_impact	-0.27	0.83	neutral	0.89	neutral	0.00	2.57	deleterious	0.16	0.45	0.1	neutral	0.2	neutral	0.34	neutral	0.33	neutral	3	0.32	neutral	0.83	deleterious	-6	neutral	0.07	neutral	1.09	medium_impact	0.35	medium_impact	-1.36	low_impact	0.59	0.8	20	12.34	0.34	N	0.62	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10312	10312	C	G	MI.15507	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	254	85	P	R	cCa/cGa	-0.17	0	0	benign	0.29	neutral	0.35	neutral	1	neutral	0.12	neutral	0.39	low_impact	1.9	0.8	neutral	0.46	neutral	0.21	4.82	deleterious	0.13	0.4	0.16	neutral	0.41	neutral	0.52	disease	0.45	neutral	1	0.58	neutral	0.53	deleterious	-6	neutral	0.25	neutral	-0.37	medium_impact	0.04	medium_impact	0.63	medium_impact	0.41	0.8	20	12.34	0.34	N	0.67	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10314	10314	C	A	MI.15508	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	256	86	L	M	Cta/Ata	-9.85	0	0	benign	0.08	neutral	0.33	neutral	0.82	neutral	-1.79	neutral	-0.16	neutral_impact	0.58	0.85	neutral	0.97	neutral	2.27	17.96	deleterious	0.27	0.45	0.23	neutral	0.18	neutral	0.31	neutral	0.3	neutral	4	0.63	neutral	0.63	deleterious	-6	neutral	0.15	neutral	0.24	medium_impact	0.02	medium_impact	-0.58	medium_impact	0.52	0.8	6.09	10.69	0.47	N	0.03	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10314	10314	C	G	MI.15509	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	256	86	L	V	Cta/Gta	-9.85	0	0	benign	0.04	neutral	0.53	neutral	0.88	neutral	-0.71	neutral	-0.62	low_impact	0.86	0.88	neutral	0.94	neutral	1.55	13.56	neutral	0.28	0.45	0.12	neutral	0.29	neutral	0.41	neutral	0.42	neutral	2	0.42	neutral	0.75	deleterious	-6	neutral	0.10	neutral	0.53	medium_impact	0.22	medium_impact	-0.32	medium_impact	0.39	0.8	6.09	10.69	0.33	N	0.20	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8415	8415	T	A	MI.1551	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	50	17	L	H	cTc/cAc	-0.1	0	0	probably_damaging	1	neutral	0.09	neutral	1.66	deleterious	-5.08	deleterious	-5.23	medium_impact	2.44	0.99	neutral	0.53	neutral	4.14	23.80	deleterious	0.24042424	0.85	0.84	disease	0.56	disease	0.64	disease	0.62	disease	2	1	deleterious	0.05	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.28	medium_impact	0.99	medium_impact	0.53	0.85	NA	NA	0.52	N	0.56	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10315	10315	T	A	MI.15510	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	257	86	L	Q	cTa/cAa	-2.94	0	0	possibly_damaging	0.87	neutral	0.31	neutral	0.81	neutral	-2.86	neutral	-1.63	medium_impact	2.07	0.8	neutral	0.81	neutral	2.58	19.99	deleterious	0.07	0.35	0.41	neutral	0.53	disease	0.46	neutral	0.48	neutral	0	0.89	neutral	0.22	neutral	0	NA	0.65	deleterious	-1.46	low_impact	0	medium_impact	0.79	medium_impact	0.17	0.8	6.09	10.69	0.34	N	0.57	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10315	10315	T	G	MI.15511	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	257	86	L	R	cTa/cGa	-2.94	0	0	possibly_damaging	0.74	neutral	0.24	neutral	0.8	neutral	-2.82	neutral	-2.05	medium_impact	2.92	0.71	neutral	0.44	neutral	2.55	19.78	deleterious	0.06	0.35	0.4	neutral	0.78	disease	0.52	disease	0.67	disease	3	0.83	neutral	0.25	neutral	0	NA	0.70	deleterious	-1.13	low_impact	-0.09	medium_impact	1.57	medium_impact	0.15	0.8	6.09	10.69	0.39	N	0.49	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10315	10315	T	C	MI.15512	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	257	86	L	P	cTa/cCa	-2.94	0	0	possibly_damaging	0.8	neutral	0.16	neutral	0.79	deleterious	-3.8	neutral	-2.41	low_impact	1.43	0.76	neutral	0.49	neutral	2.58	19.97	deleterious	0.05	0.35	0.51	disease	0.79	disease	0.61	disease	0.7	disease	4	0.9	neutral	0.18	neutral	-3	neutral	0.74	deleterious	-1.26	low_impact	-0.21	medium_impact	0.2	medium_impact	0.18	0.8	6.09	10.69	0.32	N	0.81	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10317	10317	A	C	MI.15513	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	259	87	M	L	Ata/Cta	-12.62	0	0	benign	0.04	neutral	0.77	neutral	1.08	neutral	1.57	neutral	-1.09	neutral_impact	0.5	0.81	neutral	0.91	neutral	1.39	12.72	neutral	0.29	0.45	0.15	neutral	0.51	disease	0.44	neutral	0.44	neutral	1	0.16	neutral	0.87	deleterious	-6	neutral	0.15	neutral	0.53	medium_impact	0.48	medium_impact	-0.65	medium_impact	0.36	0.8	9.57	8.6	0.29	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10317	10317	A	T	MI.15514	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	259	87	M	L	Ata/Tta	-12.62	0	0	benign	0.04	neutral	0.77	neutral	1.08	neutral	1.57	neutral	-1.09	neutral_impact	0.5	0.81	neutral	0.91	neutral	1.49	13.26	neutral	0.29	0.45	0.15	neutral	0.51	disease	0.44	neutral	0.44	neutral	1	0.16	neutral	0.87	deleterious	-6	neutral	0.15	neutral	0.53	medium_impact	0.48	medium_impact	-0.65	medium_impact	0.36	0.8	9.57	8.6	0.3	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10317	10317	A	G	MI.15515	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	259	87	M	V	Ata/Gta	-12.62	0	0	benign	0.04	neutral	0.39	neutral	1.09	neutral	1.34	neutral	-0.89	neutral_impact	0.44	0.82	neutral	0.9	neutral	-0.24	0.89	neutral	0.25	0.45	0.15	neutral	0.5	neutral	0.45	neutral	0.43	neutral	1	0.58	neutral	0.68	deleterious	-6	neutral	0.15	neutral	0.53	medium_impact	0.08	medium_impact	-0.71	medium_impact	0.44	0.8	9.57	8.6	0.32	N	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10318	10318	T	C	MI.15516	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	260	87	M	T	aTa/aCa	1.68	0	0	benign	0.01	neutral	0.57	neutral	1.04	neutral	0.26	neutral	0.08	neutral_impact	0.31	0.82	neutral	0.97	neutral	-1.63	0.00	neutral	0.15	0.45	0.16	neutral	0.12	neutral	0.4	neutral	0.25	neutral	5	0.42	neutral	0.78	deleterious	-6	neutral	0.10	neutral	1.09	medium_impact	0.26	medium_impact	-0.82	medium_impact	0.21	0.8	9.57	8.6	0.36	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10318	10318	T	A	MI.15517	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	260	87	M	K	aTa/aAa	1.68	0	0	benign	0.21	neutral	0.24	neutral	0.99	neutral	-0.93	deleterious	-2.51	medium_impact	2.31	0.72	neutral	0.4	neutral	2.38	18.69	deleterious	0.05	0.35	0.36	neutral	0.75	disease	0.6	disease	0.69	disease	4	0.71	neutral	0.52	deleterious	-3	neutral	0.29	neutral	-0.2	medium_impact	-0.09	medium_impact	1.01	medium_impact	0.20	0.8	9.57	8.6	0.39	N	1.00	disease_causing	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10319	10319	A	C	MI.15518	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	261	87	M	I	atA/atC	1.21	0	0	benign	0.01	neutral	0.62	neutral	1.05	neutral	1.15	neutral	-1.32	low_impact	1.34	0.83	neutral	0.77	neutral	1.41	12.85	neutral	0.26	0.45	0.19	neutral	0.57	disease	0.53	disease	0.55	disease	1	0.36	neutral	0.81	deleterious	-6	neutral	0.16	neutral	1.09	medium_impact	0.31	medium_impact	0.12	medium_impact	0.52	0.8	9.57	8.6	0.29	N	0.96	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10319	10319	A	T	MI.15519	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	261	87	M	I	atA/atT	1.21	0	0	benign	0.01	neutral	0.62	neutral	1.05	neutral	1.15	neutral	-1.32	low_impact	1.34	0.83	neutral	0.77	neutral	1.65	14.11	neutral	0.26	0.45	0.19	neutral	0.57	disease	0.53	disease	0.55	disease	1	0.36	neutral	0.81	deleterious	-6	neutral	0.16	neutral	1.09	medium_impact	0.31	medium_impact	0.12	medium_impact	0.52	0.8	9.57	8.6	0.29	N	0.96	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8415	8415	T	G	MI.1552	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	50	17	L	R	cTc/cGc	-0.1	0	0	probably_damaging	1	neutral	0.06	neutral	1.67	deleterious	-4.55	deleterious	-5	medium_impact	2.44	1	neutral	0.49	neutral	4.02	23.60	deleterious	0.22218516	0.85	0.77	disease	0.67	disease	0.67	disease	0.61	disease	2	1	deleterious	0.03	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	-0.38	medium_impact	0.99	medium_impact	0.50	0.85	NA	NA	0.53	N	0.65	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10320	10320	G	T	MI.15520	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	262	88	V	F	Gtt/Ttt	-1.78	0	0	benign	0	neutral	0.74	neutral	1.09	neutral	0.68	neutral	-1.19	neutral_impact	-0.38	0.76	neutral	0.75	neutral	0.09	3.53	deleterious	0.07	0.35	0.27	neutral	0.26	neutral	0.37	neutral	0.42	neutral	2	0.25	neutral	0.87	deleterious	-6	neutral	0.10	neutral	1.99	medium_impact	0.44	medium_impact	-1.46	low_impact	0.40	0.8	16.52	14.07	0.27	N	0.33	polymorphism	1	0.19	rs28358276	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10320	10320	G	A	MI.15521	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	262	88	V	I	Gtt/Att	-1.78	0	0	benign	0	neutral	0.43	neutral	0.98	neutral	-0.14	neutral	0.5	neutral_impact	-0.78	0.82	neutral	0.97	neutral	0.10	3.56	deleterious	0.42	0.55	0.13	neutral	0.12	neutral	0.33	neutral	0.26	neutral	5	0.57	neutral	0.72	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	0.12	medium_impact	-1.82	low_impact	0.71	0.85	16.52	14.07	0.34	N	0.04	polymorphism	1	0.15	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10320	10320	G	C	MI.15522	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	262	88	V	L	Gtt/Ctt	-1.78	0	0	benign	0	neutral	0.68	neutral	1.09	neutral	0.68	neutral	0.88	neutral_impact	-1.38	0.81	neutral	0.97	neutral	-1.13	0.01	neutral	0.26	0.45	0.09	neutral	0.13	neutral	0.29	neutral	0.22	neutral	6	0.32	neutral	0.84	deleterious	-6	neutral	0.06	neutral	1.99	medium_impact	0.37	medium_impact	-2.37	low_impact	0.54	0.8	16.52	14.07	0.3	N	0.07	polymorphism	1	0.15	rs28358276	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10321	10321	T	G	MI.15523	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	263	88	V	G	gTt/gGt	-1.09	0	0	benign	0.04	neutral	0.34	neutral	0.88	neutral	-2.07	deleterious	-4.47	neutral_impact	-0.38	0.72	neutral	0.49	neutral	1.94	15.86	deleterious	0.05	0.35	0.38	neutral	0.35	neutral	0.65	disease	0.49	neutral	0	0.64	neutral	0.65	deleterious	-6	neutral	0.14	neutral	0.53	medium_impact	0.03	medium_impact	-1.46	low_impact	0.24	0.8	16.52	14.07	0.32	N	0.61	polymorphism	1	0.49	rs193302928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10321	10321	T	C	MI.15524	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	263	88	V	A	gTt/gCt	-1.09	0	0	benign	0	neutral	0.52	neutral	0.93	neutral	-0.77	neutral	-2.05	neutral_impact	0.42	0.79	neutral	0.86	neutral	0.56	7.89	deleterious	0.15	0.4	0.17	neutral	0.17	neutral	0.43	neutral	0.3	neutral	4	0.48	neutral	0.76	deleterious	-6	neutral	0.09	neutral	1.99	medium_impact	0.21	medium_impact	-0.72	medium_impact	0.23	0.8	16.52	14.07	0.33	N	0.21	polymorphism	1	0.35	rs193302928	Likely_benign	not_provided	237461	MedGen:CN517202	bladder tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10321	10321	T	A	MI.15525	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	263	88	V	D	gTt/gAt	-1.09	0	0	benign	0.08	neutral	0.2	neutral	0.86	deleterious	-3.07	deleterious	-4.33	low_impact	1.83	0.7	neutral	0.46	neutral	2.69	20.80	deleterious	0.04	0.35	0.49	neutral	0.58	disease	0.75	disease	0.76	disease	5	0.78	neutral	0.56	deleterious	-6	neutral	0.23	neutral	0.24	medium_impact	-0.14	medium_impact	0.57	medium_impact	0.17	0.8	16.52	14.07	0.37	N	0.62	polymorphism	1	0.69	rs193302928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10323	10323	A	C	MI.15526	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	265	89	M	L	Atg/Ctg	-11.7	0	0	benign	0.04	neutral	0.95	neutral	1.15	neutral	1.63	neutral	0.14	neutral_impact	-0.88	0.74	neutral	0.97	neutral	-1.18	0.01	neutral	0.25	0.45	0.1	neutral	0.21	neutral	0.32	neutral	0.35	neutral	3	0.01	neutral	0.96	deleterious	-6	neutral	0.08	neutral	0.53	medium_impact	0.9	medium_impact	-1.92	low_impact	0.28	0.8	27.83	15.56	0.38	N	0.04	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10323	10323	A	T	MI.15527	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	265	89	M	L	Atg/Ttg	-11.7	0	0	benign	0.04	neutral	0.95	neutral	1.15	neutral	1.63	neutral	0.14	neutral_impact	-0.88	0.74	neutral	0.97	neutral	-1.18	0.01	neutral	0.25	0.45	0.1	neutral	0.21	neutral	0.32	neutral	0.35	neutral	3	0.01	neutral	0.96	deleterious	-6	neutral	0.08	neutral	0.53	medium_impact	0.9	medium_impact	-1.92	low_impact	0.28	0.8	27.83	15.56	0.38	N	0.04	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10323	10323	A	G	MI.15528	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	265	89	M	V	Atg/Gtg	-11.7	0	0	benign	0.04	neutral	0.45	neutral	1.15	neutral	1.59	neutral	-0.19	neutral_impact	0.31	0.82	neutral	0.95	neutral	-0.50	0.22	neutral	0.24	0.45	0.08	neutral	0.3	neutral	0.49	neutral	0.41	neutral	2	0.52	neutral	0.71	deleterious	-6	neutral	0.10	neutral	0.53	medium_impact	0.14	medium_impact	-0.82	medium_impact	0.38	0.8	27.83	15.56	0.33	N	0.02	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10324	10324	T	A	MI.15529	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	266	89	M	K	aTg/aAg	-1.09	0	0	benign	0	neutral	0.11	neutral	0.96	neutral	-0.99	neutral	-1.61	low_impact	0.98	0.89	neutral	0.71	neutral	0.69	8.76	deleterious	0.05	0.35	0.33	neutral	0.56	disease	0.62	disease	0.48	neutral	0	0.89	neutral	0.56	deleterious	-6	neutral	0.16	neutral	1.99	medium_impact	-0.31	medium_impact	-0.21	medium_impact	0.25	0.8	27.83	15.56	0.39	N	0.23	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8417	8417	C	T	MI.1553	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	52	18	L	F	Ctt/Ttt	-1.26	0	0	probably_damaging	0.99	neutral	0.45	neutral	1.75	neutral	-1.06	deleterious	-2.86	medium_impact	2	0.99	neutral	0.72	neutral	2.52	19.59	deleterious	0.62949060	0.85	0.48	neutral	0.13	neutral	0.39	neutral	0.1	neutral	8	0.99	deleterious	0.23	neutral	1	deleterious	0.71	deleterious	-2.65	low_impact	0.24	medium_impact	0.62	medium_impact	0.50	0.85	2.94	7.61	0.45	N	0.35	polymorphism	1	0.08	rs199616772	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10324	10324	T	C	MI.15530	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	266	89	M	T	aTg/aCg	-1.09	0	0	benign	0	neutral	0.53	neutral	1.02	neutral	0.4	neutral	0.21	neutral_impact	-0.5	0.88	neutral	0.98	neutral	-1.26	0.01	neutral	0.13	0.4	0.11	neutral	0.14	neutral	0.36	neutral	0.24	neutral	5	0.47	neutral	0.77	deleterious	-6	neutral	0.08	neutral	1.99	medium_impact	0.22	medium_impact	-1.57	low_impact	0.12	0.8	27.83	15.56	0.33	N	0.02	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10325	10325	G	C	MI.15531	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	267	89	M	I	atG/atC	-5.24	0	0.01	benign	0.09	neutral	0.49	neutral	1.16	neutral	1.67	neutral	-0.2	neutral_impact	-0.14	0.73	neutral	0.98	neutral	-0.25	0.86	neutral	0.27	0.45	0.09	neutral	0.21	neutral	0.34	neutral	0.33	neutral	3	0.44	neutral	0.7	deleterious	-6	neutral	0.11	neutral	0.19	medium_impact	0.18	medium_impact	-1.24	low_impact	0.34	0.8	27.83	15.56	0.4	N	0.04	disease_causing	1	0.15	rs386829097	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10325	10325	G	T	MI.15532	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	267	89	M	I	atG/atT	-5.24	0	0.01	benign	0.09	neutral	0.49	neutral	1.16	neutral	1.67	neutral	-0.2	neutral_impact	-0.14	0.73	neutral	0.98	neutral	-0.15	1.38	neutral	0.27	0.45	0.09	neutral	0.21	neutral	0.34	neutral	0.33	neutral	3	0.44	neutral	0.7	deleterious	-6	neutral	0.11	neutral	0.19	medium_impact	0.18	medium_impact	-1.24	low_impact	0.34	0.8	27.83	15.56	0.4	N	0.04	disease_causing	1	0.15	rs386829097	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10326	10326	T	G	MI.15533	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	268	90	S	A	Tca/Gca	-14.47	0	0	possibly_damaging	0.62	neutral	0.4	neutral	0.97	neutral	-0.33	neutral	-0.05	neutral_impact	0.68	0.79	neutral	0.9	neutral	2.38	18.70	deleterious	0.24	0.45	0.14	neutral	0.27	neutral	0.32	neutral	0.43	neutral	2	0.66	neutral	0.39	neutral	-3	neutral	0.48	deleterious	-0.91	medium_impact	0.09	medium_impact	-0.49	medium_impact	0.42	0.8	23.48	11.99	0.32	N	0.14	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10326	10326	T	C	MI.15534	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	268	90	S	P	Tca/Cca	-14.47	0	0	probably_damaging	0.95	neutral	0.11	neutral	0.91	neutral	-1.86	neutral	-1.56	medium_impact	2	0.59	damaging	0.38	neutral	2.91	21.90	deleterious	0.08	0.35	0.38	neutral	0.83	disease	0.51	disease	0.73	disease	5	0.98	deleterious	0.08	neutral	1	deleterious	0.75	deleterious	-1.87	low_impact	-0.31	medium_impact	0.73	medium_impact	0.34	0.8	23.48	11.99	0.31	N	0.63	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10326	10326	T	A	MI.15535	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	268	90	S	T	Tca/Aca	-14.47	0	0	benign	0.12	neutral	0.56	neutral	0.97	neutral	-0.34	neutral	0.92	neutral_impact	0.06	0.9	neutral	1	neutral	1.95	15.91	deleterious	0.23	0.45	0.11	neutral	0.14	neutral	0.19	neutral	0.27	neutral	5	0.34	neutral	0.72	deleterious	-6	neutral	0.18	neutral	0.06	medium_impact	0.25	medium_impact	-1.05	low_impact	0.43	0.8	23.48	11.99	0.39	N	0.14	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10327	10327	C	G	MI.15536	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	269	90	S	W	tCa/tGa	0.52	0	0	probably_damaging	0.98	neutral	0.37	neutral	0.89	neutral	-2.85	neutral	-0.22	neutral_impact	0.37	0.78	neutral	0.83	neutral	1.64	14.05	neutral	0.08	0.35	0.15	neutral	0.32	neutral	0.23	neutral	0.44	neutral	1	0.98	deleterious	0.2	neutral	-2	neutral	0.64	deleterious	-2.24	low_impact	0.06	medium_impact	-0.77	medium_impact	0.22	0.8	23.48	11.99	0.34	N	0.60	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10327	10327	C	T	MI.15537	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	269	90	S	L	tCa/tTa	0.52	0	0	benign	0.08	neutral	0.95	neutral	1	neutral	0.03	neutral	1.21	neutral_impact	-0.29	0.83	neutral	0.96	neutral	2.78	21.30	deleterious	0.1	0.4	0.12	neutral	0.53	disease	0.22	neutral	0.39	neutral	2	0.02	neutral	0.94	deleterious	-6	neutral	0.14	neutral	0.24	medium_impact	0.9	medium_impact	-1.37	low_impact	0.43	0.8	23.48	11.99	0.25	N	0.20	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10329	10329	T	C	MI.15538	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	271	91	S	P	Tcc/Ccc	-1.09	0	0	probably_damaging	0.97	neutral	0.24	neutral	0.94	neutral	-2.06	deleterious	-2.77	medium_impact	2.53	0.49	damaging	0.31	neutral	4.03	23.70	deleterious	0.07	0.35	0.51	disease	0.87	disease	0.74	disease	0.8	disease	6	0.98	neutral	0.14	neutral	1	deleterious	0.81	deleterious	-2.08	low_impact	-0.09	medium_impact	1.21	medium_impact	0.34	0.8	19.13	12.1	0.36	N	0.69	polymorphism	1	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10329	10329	T	A	MI.15539	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	271	91	S	T	Tcc/Acc	-1.09	0	0	benign	0.18	neutral	0.46	neutral	1.06	neutral	0.87	neutral	-0.85	neutral_impact	0.24	0.86	neutral	0.97	neutral	2.54	19.75	deleterious	0.25	0.45	0.23	neutral	0.14	neutral	0.36	neutral	0.28	neutral	4	0.45	neutral	0.64	deleterious	-6	neutral	0.28	neutral	-0.12	medium_impact	0.15	medium_impact	-0.89	medium_impact	0.35	0.8	19.13	12.1	0.37	N	0.06	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8417	8417	C	A	MI.1554	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	52	18	L	I	Ctt/Att	-1.26	0	0	probably_damaging	0.97	neutral	0.65	neutral	1.67	neutral	0.47	neutral	-0.71	low_impact	1.39	0.99	neutral	0.85	neutral	2.42	18.96	deleterious	0.56962521	0.85	0.26	neutral	0.1	neutral	0.24	neutral	0.05	neutral	9	0.97	neutral	0.34	neutral	-2	neutral	0.67	deleterious	-2.19	low_impact	0.44	medium_impact	0.09	medium_impact	0.67	0.85	2.94	7.61	0.42	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10329	10329	T	G	MI.15540	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	271	91	S	A	Tcc/Gcc	-1.09	0	0	possibly_damaging	0.73	neutral	0.6	neutral	1.05	neutral	0.74	neutral	0.43	neutral_impact	-0.08	0.78	neutral	0.99	neutral	1.02	10.77	neutral	0.28	0.45	0.09	neutral	0.09	neutral	0.31	neutral	0.21	neutral	6	0.68	neutral	0.44	neutral	-3	neutral	0.53	deleterious	-1.11	low_impact	0.29	medium_impact	-1.18	low_impact	0.31	0.8	19.13	12.1	0.34	N	0.02	polymorphism	1	0.15	rs878943163	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10330	10330	C	G	MI.15541	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	272	91	S	C	tCc/tGc	-2.01	0	0	probably_damaging	0.99	neutral	0.17	neutral	0.95	neutral	-1.66	neutral	-2.16	medium_impact	2.31	0.62	neutral	0.33	neutral	3.61	23.20	deleterious	0.1	0.4	0.61	disease	0.65	disease	0.6	disease	0.71	disease	4	0.99	deleterious	0.09	neutral	1	deleterious	0.73	deleterious	-2.52	low_impact	-0.19	medium_impact	1.01	medium_impact	0.25	0.8	19.13	12.1	0.32	N	0.53	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10330	10330	C	A	MI.15542	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	272	91	S	Y	tCc/tAc	-2.01	0	0	probably_damaging	0.98	neutral	1	neutral	0.99	neutral	-0.2	deleterious	-3.29	medium_impact	2.46	0.65	neutral	0.48	neutral	4.22	23.90	deleterious	0.08	0.35	0.7	disease	0.68	disease	0.64	disease	0.71	disease	4	0.98	deleterious	0.51	deleterious	1	deleterious	0.78	deleterious	-2.24	low_impact	1.85	high_impact	1.15	medium_impact	0.33	0.8	19.13	12.1	0.21	N	0.82	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10330	10330	C	T	MI.15543	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	272	91	S	F	tCc/tTc	-2.01	0	0	probably_damaging	0.98	neutral	0.81	neutral	1.01	neutral	0.24	deleterious	-3.25	low_impact	1.71	0.56	damaging	0.47	neutral	4.24	23.90	deleterious	0.08	0.35	0.67	disease	0.75	disease	0.5	neutral	0.52	disease	0	0.98	deleterious	0.42	neutral	-2	neutral	0.80	deleterious	-2.24	low_impact	0.54	medium_impact	0.46	medium_impact	0.32	0.8	19.13	12.1	0.25	N	0.86	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10332	10332	C	T	MI.15544	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	274	92	L	F	Ctc/Ttc	-8.7	0	0	possibly_damaging	0.77	neutral	0.84	neutral	0.91	neutral	-1.56	neutral	-0.75	neutral_impact	0.7	0.76	neutral	0.98	neutral	1.91	15.66	deleterious	0.27	0.45	0.22	neutral	0.19	neutral	0.27	neutral	0.36	neutral	3	0.73	neutral	0.54	deleterious	-3	neutral	0.59	deleterious	-1.19	low_impact	0.59	medium_impact	-0.47	medium_impact	0.48	0.8	18.26	12.33	0.31	N	0.14	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10332	10332	C	G	MI.15545	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	274	92	L	V	Ctc/Gtc	-8.7	0	0	benign	0.23	neutral	0.42	neutral	0.9	neutral	-0.84	neutral	-1.35	low_impact	1.38	0.8	neutral	0.77	neutral	2.18	17.41	deleterious	0.28	0.45	0.17	neutral	0.26	neutral	0.3	neutral	0.44	neutral	1	0.49	neutral	0.6	deleterious	-6	neutral	0.29	neutral	-0.24	medium_impact	0.11	medium_impact	0.16	medium_impact	0.57	0.8	18.26	12.33	0.33	N	0.34	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10332	10332	C	A	MI.15546	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	274	92	L	I	Ctc/Atc	-8.7	0	0	benign	0.07	neutral	0.72	neutral	0.97	neutral	-0.83	neutral	-0.74	low_impact	0.86	0.85	neutral	0.86	neutral	2.69	20.70	deleterious	0.28	0.45	0.15	neutral	0.26	neutral	0.26	neutral	0.43	neutral	2	0.19	neutral	0.83	deleterious	-6	neutral	0.14	neutral	0.3	medium_impact	0.42	medium_impact	-0.32	medium_impact	0.50	0.8	18.26	12.33	0.3	N	0.10	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10333	10333	T	C	MI.15547	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	275	92	L	P	cTc/cCc	-2.94	0	0	probably_damaging	0.93	neutral	0.12	neutral	0.76	deleterious	-4	deleterious	-4.6	high_impact	3.73	0.57	damaging	0.3	neutral	3.84	23.40	deleterious	0.04	0.35	0.51	disease	0.76	disease	0.61	disease	0.73	disease	5	0.97	neutral	0.1	neutral	2	deleterious	0.74	deleterious	-1.73	low_impact	-0.29	medium_impact	2.31	high_impact	0.33	0.8	18.26	12.33	0.38	N	0.88	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10333	10333	T	A	MI.15548	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	275	92	L	H	cTc/cAc	-2.94	0	0	probably_damaging	0.97	neutral	0.31	neutral	0.77	deleterious	-3.95	deleterious	-3.91	high_impact	3.73	0.74	neutral	0.48	neutral	2.96	22.10	deleterious	0.06	0.35	0.49	neutral	0.53	disease	0.52	disease	0.59	disease	2	0.97	neutral	0.17	neutral	2	deleterious	0.70	deleterious	-2.08	low_impact	0	medium_impact	2.31	high_impact	0.17	0.8	18.26	12.33	0.45	N	0.70	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10333	10333	T	G	MI.15549	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	275	92	L	R	cTc/cGc	-2.94	0	0	possibly_damaging	0.88	neutral	0.2	neutral	0.78	deleterious	-3.38	deleterious	-3.87	high_impact	3.73	0.69	neutral	0.39	neutral	3.12	22.60	deleterious	0.04	0.35	0.4	neutral	0.74	disease	0.59	disease	0.71	disease	4	0.92	neutral	0.16	neutral	1	deleterious	0.71	deleterious	-1.5	low_impact	-0.14	medium_impact	2.31	high_impact	0.20	0.8	18.26	12.33	0.46	N	0.79	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8417	8417	C	G	MI.1555	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	52	18	L	V	Ctt/Gtt	-1.26	0	0	probably_damaging	0.97	neutral	0.2	neutral	1.59	neutral	-2.87	neutral	-1.18	low_impact	1.34	1	neutral	0.92	neutral	1.98	16.08	deleterious	0.62949060	0.85	0.31	neutral	0.13	neutral	0.36	neutral	0.1	neutral	8	0.98	deleterious	0.12	neutral	-2	neutral	0.69	deleterious	-2.19	low_impact	-0.05	medium_impact	0.05	medium_impact	0.46	0.85	2.94	7.61	0.61	P	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10335	10335	T	G	MI.15550	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	277	93	L	V	Tta/Gta	-20	0	0	benign	0.01	neutral	0.25	neutral	0.95	neutral	-0.07	neutral	0.08	low_impact	0.87	0.81	neutral	0.97	neutral	-0.83	0.04	neutral	0.22	0.45	0.14	neutral	0.18	neutral	0.24	neutral	0.28	neutral	4	0.74	neutral	0.62	deleterious	-6	neutral	0.10	neutral	1.09	medium_impact	-0.08	medium_impact	-0.31	medium_impact	0.39	0.8	15.65	9.34	0.44	N	0.16	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10335	10335	T	A	MI.15551	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	277	93	L	M	Tta/Ata	-20	0	0	benign	0.03	neutral	0.32	neutral	0.81	neutral	-1.96	neutral	-0.07	neutral_impact	0.37	0.86	neutral	0.96	neutral	0.27	5.40	deleterious	0.22	0.45	0.31	neutral	0.13	neutral	0.27	neutral	0.3	neutral	4	0.66	neutral	0.65	deleterious	-6	neutral	0.12	neutral	0.65	medium_impact	0.01	medium_impact	-0.77	medium_impact	0.32	0.8	15.65	9.34	0.47	N	0.04	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10336	10336	T	G	MI.15552	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	278	93	L	W	tTa/tGa	-8.7	0	0.02	possibly_damaging	0.89	neutral	0.24	neutral	0.73	deleterious	-4.84	deleterious	-2.53	medium_impact	2.88	0.75	neutral	0.37	neutral	2.61	20.20	deleterious	0.07	0.35	0.66	disease	0.49	neutral	0.46	neutral	0.54	disease	1	0.92	neutral	0.18	neutral	0	NA	0.68	deleterious	-1.54	low_impact	-0.09	medium_impact	1.53	medium_impact	0.15	0.8	15.65	9.34	0.36	N	0.40	polymorphism	1	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10336	10336	T	C	MI.15553	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	278	93	L	S	tTa/tCa	-8.7	0	0.02	benign	0.18	neutral	0.49	neutral	0.79	neutral	-2.54	neutral	-0.75	low_impact	1.29	0.86	neutral	0.98	neutral	0.58	7.99	deleterious	0.08	0.35	0.32	neutral	0.24	neutral	0.34	neutral	0.43	neutral	1	0.41	neutral	0.66	deleterious	-6	neutral	0.21	neutral	-0.12	medium_impact	0.18	medium_impact	0.07	medium_impact	0.22	0.8	15.65	9.34	0.39	N	0.17	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10337	10337	A	C	MI.15554	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	279	93	L	F	ttA/ttC	-2.24	0	0	benign	0.26	neutral	0.77	neutral	0.85	neutral	-1.39	neutral	-1.2	neutral_impact	0.71	0.81	neutral	0.96	neutral	0.27	5.36	deleterious	0.27	0.45	0.22	neutral	0.21	neutral	0.26	neutral	0.36	neutral	3	0.17	neutral	0.76	deleterious	-6	neutral	0.33	neutral	-0.31	medium_impact	0.48	medium_impact	-0.46	medium_impact	0.33	0.8	15.65	9.34	0.31	N	0.06	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10337	10337	A	T	MI.15555	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	279	93	L	F	ttA/ttT	-2.24	0	0	benign	0.26	neutral	0.77	neutral	0.85	neutral	-1.39	neutral	-1.2	neutral_impact	0.71	0.81	neutral	0.96	neutral	0.35	6.12	deleterious	0.27	0.45	0.22	neutral	0.21	neutral	0.26	neutral	0.36	neutral	3	0.17	neutral	0.76	deleterious	-6	neutral	0.33	neutral	-0.31	medium_impact	0.48	medium_impact	-0.46	medium_impact	0.33	0.8	15.65	9.34	0.3	N	0.06	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10338	10338	T	A	MI.15556	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	280	94	L	M	Tta/Ata	-8.24	0	0	probably_damaging	0.98	neutral	0.25	neutral	0.78	neutral	-2.35	neutral	-1.75	medium_impact	2.54	0.81	neutral	0.66	neutral	3.53	23.10	deleterious	0.13	0.4	0.41	neutral	0.32	neutral	0.41	neutral	0.47	neutral	1	0.98	deleterious	0.14	neutral	1	deleterious	0.68	deleterious	-2.24	low_impact	-0.08	medium_impact	1.22	medium_impact	0.32	0.8	NA	NA	0.4	N	0.60	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10338	10338	T	G	MI.15557	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	280	94	L	V	Tta/Gta	-8.24	0	0	possibly_damaging	0.86	neutral	0.23	neutral	0.81	neutral	-1.66	neutral	-2.35	low_impact	1.71	0.81	neutral	0.73	neutral	1.91	15.67	deleterious	0.15	0.4	0.25	neutral	0.2	neutral	0.27	neutral	0.38	neutral	2	0.9	neutral	0.19	neutral	-3	neutral	0.61	deleterious	-1.43	low_impact	-0.1	medium_impact	0.46	medium_impact	0.30	0.8	NA	NA	0.41	N	0.50	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10339	10339	T	G	MI.15558	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	281	94	L	W	tTa/tGa	-2.48	0	0	probably_damaging	0.99	neutral	0.06	neutral	0.72	deleterious	-5.25	deleterious	-5.36	high_impact	3.83	0.74	neutral	0.27	damaging	3.78	23.40	deleterious	0.04	0.35	0.84	disease	0.66	disease	0.54	disease	0.66	disease	3	1	deleterious	0.04	neutral	2	deleterious	0.78	deleterious	-2.52	low_impact	-0.47	medium_impact	2.4	high_impact	0.12	0.8	NA	NA	0.37	N	0.83	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10339	10339	T	C	MI.15559	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	281	94	L	S	tTa/tCa	-2.48	0	0	probably_damaging	0.97	neutral	0.25	neutral	0.73	deleterious	-4.22	deleterious	-5.34	medium_impact	2.79	0.69	neutral	0.36	neutral	3.83	23.40	deleterious	0.05	0.35	0.67	disease	0.53	disease	0.54	disease	0.63	disease	3	0.98	neutral	0.14	neutral	1	deleterious	0.74	deleterious	-2.08	low_impact	-0.08	medium_impact	1.45	medium_impact	0.17	0.8	NA	NA	0.32	N	0.90	polymorphism	1	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8418	8418	T	C	MI.1556	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	53	18	L	P	cTt/cCt	-14.68	0	0	probably_damaging	1	deleterious	0.02	neutral	1.51	deleterious	-6.55	deleterious	-3.76	medium_impact	2.19	0.98	neutral	0.7	neutral	2.55	19.82	deleterious	0.32447288	0.85	0.78	disease	0.12	neutral	0.56	disease	0.06	neutral	9	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-3.6	low_impact	-0.66	medium_impact	0.78	medium_impact	0.54	0.85	2.94	7.61	0.52	N	0.33	polymorphism	1	0.10	rs1057516062	Likely_pathogenic	Optic_neuropathy	354303	Human_Phenotype_Ontology:HP:0001138,MedGen:C3887709	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	10340	10340	A	T	MI.15560	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	282	94	L	F	ttA/ttT	5.83	0.89	0	benign	0.17	neutral	0.49	neutral	1.66	neutral	2.06	deleterious	-3.55	neutral_impact	-0.1	0.82	neutral	0.68	neutral	3.53	23.10	deleterious	0.12	0.4	0.21	neutral	0.25	neutral	0.35	neutral	0.42	neutral	2	0.41	neutral	0.66	deleterious	-6	neutral	0.24	neutral	-0.1	medium_impact	0.18	medium_impact	-1.2	low_impact	0.22	0.8	NA	NA	0.5	N	0.27	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10340	10340	A	C	MI.15561	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	282	94	L	F	ttA/ttC	5.83	0.89	0	benign	0.17	neutral	0.49	neutral	1.66	neutral	2.06	deleterious	-3.55	neutral_impact	-0.1	0.82	neutral	0.68	neutral	3.41	23.00	deleterious	0.12	0.4	0.21	neutral	0.25	neutral	0.35	neutral	0.42	neutral	2	0.41	neutral	0.66	deleterious	-6	neutral	0.24	neutral	-0.1	medium_impact	0.18	medium_impact	-1.2	low_impact	0.22	0.8	NA	NA	0.49	N	0.27	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10341	10341	A	C	MI.15562	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	283	95	I	L	Atc/Ctc	-5.7	0	0	possibly_damaging	0.62	neutral	0.78	neutral	1.2	neutral	-0.02	neutral	-1.06	neutral_impact	0.66	0.73	neutral	0.91	neutral	1.64	14.07	neutral	0.15	0.4	0.11	neutral	0.21	neutral	0.28	neutral	0.36	neutral	3	0.54	neutral	0.58	deleterious	-3	neutral	0.40	neutral	-0.91	medium_impact	0.5	medium_impact	-0.5	medium_impact	0.31	0.8	NA	NA	0.33	N	0.64	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10341	10341	A	T	MI.15563	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	283	95	I	F	Atc/Ttc	-5.7	0	0	probably_damaging	0.96	neutral	0.71	neutral	0.86	neutral	-1.43	deleterious	-3.41	low_impact	0.96	0.73	neutral	0.23	damaging	3.79	23.40	deleterious	0.16	0.45	0.5	neutral	0.71	disease	0.5	neutral	0.5	disease	0	0.95	neutral	0.38	neutral	-2	neutral	0.71	deleterious	-1.96	low_impact	0.41	medium_impact	-0.23	medium_impact	0.29	0.8	NA	NA	0.18	N	0.89	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10341	10341	A	G	MI.15564	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	283	95	I	V	Atc/Gtc	-5.7	0	0	benign	0.18	neutral	0.59	neutral	1	neutral	-0.33	neutral	-0.67	low_impact	1.17	0.75	neutral	0.96	neutral	1.71	14.47	neutral	0.27	0.45	0.15	neutral	0.34	neutral	0.45	neutral	0.44	neutral	1	0.3	neutral	0.71	deleterious	-6	neutral	0.15	neutral	-0.12	medium_impact	0.28	medium_impact	-0.04	medium_impact	0.17	0.8	NA	NA	0.33	N	0.13	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10342	10342	T	G	MI.15565	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	284	95	I	S	aTc/aGc	0.06	0	0	probably_damaging	0.95	neutral	0.12	neutral	0.84	neutral	-2.91	deleterious	-5.04	medium_impact	3.11	0.61	neutral	0.11	damaging	4.32	24.00	deleterious	0.05	0.35	0.67	disease	0.75	disease	0.64	disease	0.71	disease	4	0.98	neutral	0.09	neutral	1	deleterious	0.74	deleterious	-1.87	low_impact	-0.29	medium_impact	1.74	medium_impact	0.23	0.8	NA	NA	0.29	N	0.94	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10342	10342	T	A	MI.15566	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	284	95	I	N	aTc/aAc	0.06	0	0	probably_damaging	0.98	deleterious	0.01	neutral	0.8	deleterious	-4.12	deleterious	-6.01	medium_impact	3.21	0.6	neutral	0.11	damaging	4.62	24.50	deleterious	0.1	0.4	0.8	disease	0.74	disease	0.67	disease	0.75	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-2.24	low_impact	-0.92	medium_impact	1.83	medium_impact	0.31	0.8	NA	NA	0.26	N	0.99	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10342	10342	T	C	MI.15567	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	284	95	I	T	aTc/aCc	0.06	0	0	possibly_damaging	0.86	neutral	0.1	neutral	0.86	neutral	-2.33	deleterious	-4.01	medium_impact	2.69	0.76	neutral	0.22	damaging	3.51	23.10	deleterious	0.12	0.4	0.53	disease	0.47	neutral	0.63	disease	0.6	disease	2	0.95	neutral	0.12	neutral	0	NA	0.63	deleterious	-1.43	low_impact	-0.34	medium_impact	1.36	medium_impact	0.28	0.8	NA	NA	0.33	N	0.90	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10343	10343	C	A	MI.15568	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	285	95	I	M	atC/atA	5.83	0.89	0	probably_damaging	0.98	neutral	0.31	neutral	0.85	neutral	-1.73	neutral	-2.1	medium_impact	2.21	0.72	neutral	0.2	damaging	3.93	23.50	deleterious	0.23	0.45	0.44	neutral	0.54	disease	0.43	neutral	0.49	neutral	0	0.98	deleterious	0.17	neutral	1	deleterious	0.67	deleterious	-2.24	low_impact	0	medium_impact	0.92	medium_impact	0.37	0.8	NA	NA	0.47	N	0.58	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10343	10343	C	G	MI.15569	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	285	95	I	M	atC/atG	5.83	0.89	0	probably_damaging	0.98	neutral	0.31	neutral	0.85	neutral	-1.73	neutral	-2.1	medium_impact	2.21	0.72	neutral	0.2	damaging	3.43	23.00	deleterious	0.23	0.45	0.44	neutral	0.54	disease	0.43	neutral	0.49	neutral	0	0.98	deleterious	0.17	neutral	1	deleterious	0.67	deleterious	-2.24	low_impact	0	medium_impact	0.92	medium_impact	0.37	0.8	NA	NA	0.47	N	0.58	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8418	8418	T	G	MI.1557	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	53	18	L	R	cTt/cGt	-14.68	0	0	probably_damaging	1	deleterious	0.04	neutral	1.51	deleterious	-6.18	deleterious	-4.42	medium_impact	3.4	1	neutral	0.41	neutral	3.95	23.60	deleterious	0.23173347	0.85	0.71	disease	0.55	disease	0.69	disease	0.6	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-3.6	low_impact	-0.49	medium_impact	1.82	medium_impact	0.66	0.85	2.94	7.61	0.53	N	0.68	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10344	10344	A	C	MI.15570	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	286	96	I	L	Atc/Ctc	-13.77	0	0.01	benign	0.08	neutral	1	neutral	1.12	neutral	0.77	neutral	-0.23	neutral_impact	-0.56	0.83	neutral	0.97	neutral	0.34	6.11	deleterious	0.2	0.45	0.11	neutral	0.24	neutral	0.26	neutral	0.41	neutral	2	0.08	neutral	0.96	deleterious	-6	neutral	0.11	neutral	0.24	medium_impact	1.85	high_impact	-1.62	low_impact	0.47	0.8	18.26	11.99	0.29	N	0.14	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10344	10344	A	T	MI.15571	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	286	96	I	F	Atc/Ttc	-13.77	0	0.01	possibly_damaging	0.56	neutral	0.66	neutral	0.91	neutral	-0.99	neutral	-1.32	neutral_impact	0.78	0.85	neutral	0.97	neutral	0.89	10.03	neutral	0.17	0.45	0.32	neutral	0.47	neutral	0.32	neutral	0.46	neutral	1	0.48	neutral	0.55	deleterious	-3	neutral	0.45	deleterious	-0.81	medium_impact	0.35	medium_impact	-0.39	medium_impact	0.33	0.8	18.26	11.99	0.3	N	0.44	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10344	10344	A	G	MI.15572	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	286	96	I	V	Atc/Gtc	-13.77	0	0.01	benign	0.01	neutral	0.23	neutral	1.06	neutral	0.41	neutral	-0.16	neutral_impact	0.58	0.83	neutral	0.81	neutral	-0.79	0.05	neutral	0.37	0.5	0.15	neutral	0.17	neutral	0.3	neutral	0.3	neutral	4	0.76	neutral	0.61	deleterious	-6	neutral	0.09	neutral	1.09	medium_impact	-0.1	medium_impact	-0.58	medium_impact	0.41	0.8	18.26	11.99	0.43	N	0.43	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10345	10345	T	A	MI.15573	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	287	96	I	N	aTc/aAc	-4.32	0	0.06	benign	0.4	neutral	0.09	neutral	0.84	neutral	-2.95	neutral	-1.43	medium_impact	3.25	0.72	neutral	0.36	neutral	2.60	20.20	deleterious	0.11	0.4	0.42	neutral	0.58	disease	0.56	disease	0.67	disease	3	0.9	neutral	0.35	neutral	-3	neutral	0.37	neutral	-0.56	medium_impact	-0.37	medium_impact	1.87	medium_impact	0.25	0.8	18.26	11.99	0.39	N	0.50	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10345	10345	T	G	MI.15574	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	287	96	I	S	aTc/aGc	-4.32	0	0.06	benign	0.19	neutral	0.16	neutral	0.91	neutral	-1.03	neutral	0.24	neutral_impact	0.29	0.8	neutral	1	neutral	0.40	6.62	deleterious	0.06	0.35	0.2	neutral	0.42	neutral	0.35	neutral	0.43	neutral	1	0.81	neutral	0.49	deleterious	-6	neutral	0.18	neutral	-0.15	medium_impact	-0.21	medium_impact	-0.84	medium_impact	0.31	0.8	18.26	11.99	0.38	N	0.13	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10345	10345	T	C	MI.15575	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	287	96	I	T	aTc/aCc	-4.32	0	0.06	benign	0.01	neutral	0.15	neutral	0.92	neutral	-1.03	neutral	0.16	neutral_impact	0.76	0.9	neutral	0.99	neutral	-0.13	1.50	neutral	0.15	0.4	0.14	neutral	0.19	neutral	0.32	neutral	0.35	neutral	3	0.85	neutral	0.57	deleterious	-6	neutral	0.09	neutral	1.09	medium_impact	-0.23	medium_impact	-0.41	medium_impact	0.34	0.8	18.26	11.99	0.4	N	0.06	polymorphism	1	0.20	rs201397417	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10346	10346	C	G	MI.15576	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	288	96	I	M	atC/atG	-2.01	0	0	possibly_damaging	0.71	neutral	0.1	neutral	0.9	neutral	-1.25	neutral	-0.18	low_impact	1.3	0.8	neutral	0.87	neutral	0.52	7.56	deleterious	0.26	0.45	0.32	neutral	0.27	neutral	0.3	neutral	0.45	neutral	1	0.92	neutral	0.2	neutral	-3	neutral	0.47	deleterious	-1.07	low_impact	-0.34	medium_impact	0.08	medium_impact	0.38	0.8	18.26	11.99	0.46	N	0.48	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10346	10346	C	A	MI.15577	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	288	96	I	M	atC/atA	-2.01	0	0	possibly_damaging	0.71	neutral	0.1	neutral	0.9	neutral	-1.25	neutral	-0.18	low_impact	1.3	0.8	neutral	0.87	neutral	1.04	10.90	neutral	0.26	0.45	0.32	neutral	0.27	neutral	0.3	neutral	0.45	neutral	1	0.92	neutral	0.2	neutral	-3	neutral	0.47	deleterious	-1.07	low_impact	-0.34	medium_impact	0.08	medium_impact	0.38	0.8	18.26	11.99	0.46	N	0.48	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10347	10347	A	C	MI.15578	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	289	97	I	L	Atc/Ctc	-20	0	0	probably_damaging	0.99	neutral	1	neutral	0.96	neutral	-0.21	neutral	-0.52	neutral_impact	0.74	0.75	neutral	0.96	neutral	1.10	11.22	neutral	0.17	0.45	0.09	neutral	0.18	neutral	0.25	neutral	0.27	neutral	5	0.99	deleterious	0.51	deleterious	-2	neutral	0.62	deleterious	-2.52	low_impact	1.85	high_impact	-0.43	medium_impact	0.23	0.8	13.91	12.04	0.31	N	0.05	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10347	10347	A	T	MI.15579	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	289	97	I	F	Atc/Ttc	-20	0	0	probably_damaging	1	neutral	0.38	neutral	0.85	neutral	-1.18	deleterious	-3.04	medium_impact	2.41	0.75	neutral	0.76	neutral	3.79	23.40	deleterious	0.13	0.4	0.47	neutral	0.73	disease	0.55	disease	0.61	disease	2	1	deleterious	0.19	neutral	1	deleterious	0.75	deleterious	-3.43	low_impact	0.07	medium_impact	1.1	medium_impact	0.25	0.8	13.91	12.04	0.36	N	0.61	polymorphism	1	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8418	8418	T	A	MI.1558	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	53	18	L	H	cTt/cAt	-14.68	0	0	probably_damaging	1	neutral	0.06	neutral	1.5	deleterious	-6.87	deleterious	-5.03	medium_impact	3.4	0.99	neutral	0.45	neutral	3.92	23.50	deleterious	0.25207871	0.85	0.79	disease	0.4	neutral	0.65	disease	0.25	neutral	5	1	deleterious	0.03	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	-0.38	medium_impact	1.82	medium_impact	0.57	0.85	2.94	7.61	0.53	N	0.62	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10347	10347	A	G	MI.15580	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	289	97	I	V	Atc/Gtc	-20	0	0	probably_damaging	0.99	neutral	0.2	neutral	0.93	neutral	-0.39	neutral	-0.76	low_impact	1.16	0.81	neutral	0.9	neutral	1.94	15.82	deleterious	0.33	0.5	0.13	neutral	0.34	neutral	0.4	neutral	0.44	neutral	1	0.99	deleterious	0.11	neutral	-2	neutral	0.61	deleterious	-2.52	low_impact	-0.14	medium_impact	-0.05	medium_impact	0.23	0.8	13.91	12.04	0.36	N	0.10	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10348	10348	T	C	MI.15581	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	290	97	I	T	aTc/aCc	-0.4	0	0	probably_damaging	1	neutral	0.17	neutral	0.81	neutral	-1.68	deleterious	-3.63	medium_impact	2.8	0.78	neutral	0.6	neutral	3.47	23.00	deleterious	0.12	0.4	0.51	disease	0.47	neutral	0.54	disease	0.52	disease	0	1	deleterious	0.09	neutral	1	deleterious	0.70	deleterious	-3.43	low_impact	-0.19	medium_impact	1.46	medium_impact	0.23	0.8	13.91	12.04	0.39	N	0.78	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10348	10348	T	G	MI.15582	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	290	97	I	S	aTc/aGc	-0.4	0	0	probably_damaging	1	deleterious	0.04	neutral	0.77	neutral	-2.44	deleterious	-4.58	medium_impact	3.29	0.69	neutral	0.41	neutral	4.35	24.10	deleterious	0.06	0.35	0.65	disease	0.75	disease	0.59	disease	0.7	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-3.43	low_impact	-0.58	medium_impact	1.91	medium_impact	0.15	0.8	13.91	12.04	0.38	N	0.86	polymorphism	1	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10348	10348	T	A	MI.15583	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	290	97	I	N	aTc/aAc	-0.4	0	0	probably_damaging	1	deleterious	0.02	neutral	0.74	deleterious	-3.68	deleterious	-5.61	high_impact	3.72	0.65	neutral	0.41	neutral	4.52	24.30	deleterious	0.11	0.4	0.78	disease	0.8	disease	0.6	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-3.43	low_impact	-0.75	medium_impact	2.3	high_impact	0.19	0.8	13.91	12.04	0.33	N	0.89	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10349	10349	C	G	MI.15584	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	291	97	I	M	atC/atG	5.83	0.89	0	probably_damaging	1	neutral	0.13	neutral	0.83	neutral	-1.35	neutral	-1.71	medium_impact	2.83	0.75	neutral	0.67	neutral	3.39	23.00	deleterious	0.25	0.45	0.42	neutral	0.52	disease	0.52	disease	0.51	disease	0	1	deleterious	0.07	neutral	1	deleterious	0.69	deleterious	-3.43	low_impact	-0.27	medium_impact	1.49	medium_impact	0.28	0.8	13.91	12.04	0.53	P	0.62	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10349	10349	C	A	MI.15585	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	291	97	I	M	atC/atA	5.83	0.89	0	probably_damaging	1	neutral	0.13	neutral	0.83	neutral	-1.35	neutral	-1.71	medium_impact	2.83	0.75	neutral	0.67	neutral	3.87	23.50	deleterious	0.25	0.45	0.42	neutral	0.52	disease	0.52	disease	0.51	disease	0	1	deleterious	0.07	neutral	1	deleterious	0.69	deleterious	-3.43	low_impact	-0.27	medium_impact	1.49	medium_impact	0.28	0.8	13.91	12.04	0.54	P	0.62	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10350	10350	C	G	MI.15586	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	292	98	L	V	Cta/Gta	-8.24	0	0	probably_damaging	1	neutral	0.21	neutral	0.39	neutral	-2.57	deleterious	-2.89	medium_impact	3.38	0.57	damaging	0.1	damaging	3.45	23.00	deleterious	0.15	0.4	0.25	neutral	0.49	neutral	0.63	disease	0.54	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.69	deleterious	-3.43	low_impact	-0.13	medium_impact	1.99	medium_impact	0.41	0.8	1.74	6.79	0.33	N	0.89	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10350	10350	C	A	MI.15587	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	292	98	L	M	Cta/Ata	-8.24	0	0	probably_damaging	1	neutral	0.09	neutral	0.32	deleterious	-3.5	neutral	-1.92	high_impact	3.87	0.63	neutral	0.1	damaging	3.74	23.30	deleterious	0.15	0.4	0.48	neutral	0.47	neutral	0.62	disease	0.45	neutral	1	1	deleterious	0.05	neutral	2	deleterious	0.71	deleterious	-3.43	low_impact	-0.37	medium_impact	2.44	high_impact	0.39	0.8	1.74	6.79	0.37	N	0.91	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10351	10351	T	G	MI.15588	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	293	98	L	R	cTa/cGa	-0.63	0	0	probably_damaging	1	deleterious	0.02	neutral	0.25	deleterious	-5.7	deleterious	-5.74	high_impact	4.91	0.55	damaging	0.03	damaging	4.22	23.90	deleterious	0.02	0.35	0.8	disease	0.81	disease	0.76	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.43	low_impact	-0.75	medium_impact	3.39	high_impact	0.09	0.8	1.74	6.79	0.6	P	1.00	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10351	10351	T	C	MI.15589	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	293	98	L	P	cTa/cCa	-0.63	0	0	probably_damaging	1	deleterious	0.01	neutral	0.3	deleterious	-3.7	deleterious	-6.67	high_impact	4.55	0.47	damaging	0.04	damaging	3.96	23.60	deleterious	0.02	0.35	0.85	disease	0.75	disease	0.77	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.43	low_impact	-0.92	medium_impact	3.06	high_impact	0.20	0.8	1.74	6.79	0.5	P	0.99	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8420	8420	A	T	MI.1559	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	55	19	T	S	Aca/Tca	-10.05	0	0	probably_damaging	0.97	neutral	0.18	neutral	2.02	neutral	0.12	deleterious	-3.02	medium_impact	2.04	1	neutral	0.77	neutral	3.05	22.40	deleterious	0.59098804	0.85	0.57	disease	0.15	neutral	0.48	neutral	0.1	neutral	8	0.98	deleterious	0.11	neutral	1	deleterious	0.70	deleterious	-2.19	low_impact	-0.08	medium_impact	0.65	medium_impact	0.63	0.85	NA	NA	0.55	P	0.08	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10351	10351	T	A	MI.15590	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	293	98	L	Q	cTa/cAa	-0.63	0	0	probably_damaging	1	deleterious	0.02	neutral	0.25	deleterious	-5.77	deleterious	-5.73	high_impact	4.55	0.55	damaging	0.05	damaging	4.12	23.80	deleterious	0.03	0.35	0.8	disease	0.69	disease	0.69	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.43	low_impact	-0.75	medium_impact	3.06	high_impact	0.23	0.8	1.74	6.79	0.37	N	0.97	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10353	10353	G	C	MI.15591	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	295	99	A	P	Gcc/Ccc	-0.63	0	0	possibly_damaging	0.58	deleterious	0.02	neutral	0.88	neutral	-2.83	deleterious	-3.11	medium_impact	3.46	0.64	neutral	0.32	neutral	2.27	17.96	deleterious	0.07	0.35	0.51	disease	0.9	disease	0.66	disease	0.81	disease	6	0.98	neutral	0.22	neutral	4	deleterious	0.64	deleterious	-0.84	medium_impact	-0.75	medium_impact	2.06	high_impact	0.48	0.8	12.17	9.19	0.36	N	0.75	polymorphism	1	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10353	10353	G	A	MI.15592	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	295	99	A	T	Gcc/Acc	-0.63	0	0	benign	0.01	neutral	0.14	neutral	0.97	neutral	-0.39	neutral	-0.51	neutral_impact	0.26	0.84	neutral	0.9	neutral	-0.37	0.45	neutral	0.22	0.45	0.12	neutral	0.06	neutral	0.25	neutral	0.22	neutral	6	0.86	neutral	0.57	deleterious	-6	neutral	0.09	neutral	1.09	medium_impact	-0.25	medium_impact	-0.87	medium_impact	0.63	0.8	12.17	9.19	0.49	N	0.16	polymorphism	1	0.16	rs28435660	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10353	10353	G	T	MI.15593	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	295	99	A	S	Gcc/Tcc	-0.63	0	0	benign	0.2	neutral	0.1	neutral	0.95	neutral	-0.59	neutral	-0.83	low_impact	1.26	0.79	neutral	0.88	neutral	0.70	8.81	deleterious	0.3	0.45	0.21	neutral	0.54	disease	0.33	neutral	0.45	neutral	1	0.88	neutral	0.45	neutral	-6	neutral	0.21	neutral	-0.17	medium_impact	-0.34	medium_impact	0.05	medium_impact	0.36	0.8	12.17	9.19	0.4	N	0.25	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10354	10354	C	G	MI.15594	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	296	99	A	G	gCc/gGc	0.29	0	0	benign	0.29	neutral	0.18	neutral	0.89	neutral	-2.3	deleterious	-2.8	low_impact	1.86	0.78	neutral	0.65	neutral	2.16	17.22	deleterious	0.25	0.45	0.38	neutral	0.6	disease	0.42	neutral	0.47	neutral	1	0.79	neutral	0.45	neutral	-6	neutral	0.27	neutral	-0.37	medium_impact	-0.18	medium_impact	0.6	medium_impact	0.54	0.8	12.17	9.19	0.37	N	0.39	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10354	10354	C	A	MI.15595	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	296	99	A	D	gCc/gAc	0.29	0	0	possibly_damaging	0.5	deleterious	0.02	neutral	0.88	deleterious	-3.34	deleterious	-3.48	medium_impact	3.46	0.62	neutral	0.31	neutral	3.03	22.30	deleterious	0.05	0.35	0.46	neutral	0.87	disease	0.64	disease	0.8	disease	6	0.98	neutral	0.26	neutral	4	deleterious	0.43	neutral	-0.72	medium_impact	-0.75	medium_impact	2.06	high_impact	0.24	0.8	12.17	9.19	0.38	N	0.80	polymorphism	1	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10354	10354	C	T	MI.15596	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	296	99	A	V	gCc/gTc	0.29	0	0	benign	0.02	neutral	0.11	neutral	1.07	neutral	0.67	neutral	-2.17	low_impact	0.93	0.78	neutral	0.62	neutral	2.51	19.56	deleterious	0.2	0.45	0.29	neutral	0.64	disease	0.36	neutral	0.48	neutral	0	0.89	neutral	0.55	deleterious	-6	neutral	0.17	neutral	0.81	medium_impact	-0.31	medium_impact	-0.26	medium_impact	0.62	0.8	12.17	9.19	0.36	N	0.43	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10356	10356	C	A	MI.15597	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	298	100	L	M	Cta/Ata	-7.55	0	0	probably_damaging	1	neutral	0.15	neutral	0.81	neutral	-2.37	neutral	-1.44	low_impact	1.92	0.81	neutral	0.87	neutral	3.80	23.40	deleterious	0.32	0.5	0.33	neutral	0.4	neutral	0.37	neutral	0.45	neutral	1	1	deleterious	0.08	neutral	-2	neutral	0.67	deleterious	-3.43	low_impact	-0.23	medium_impact	0.65	medium_impact	0.54	0.8	5.22	9.73	0.41	N	0.54	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10356	10356	C	G	MI.15598	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	298	100	L	V	Cta/Gta	-7.55	0	0	probably_damaging	1	neutral	0.27	neutral	0.98	neutral	0.53	neutral	-1.83	low_impact	1.38	0.85	neutral	0.93	neutral	2.39	18.75	deleterious	0.3	0.45	0.18	neutral	0.38	neutral	0.34	neutral	0.43	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.66	deleterious	-3.43	low_impact	-0.05	medium_impact	0.16	medium_impact	0.45	0.8	5.22	9.73	0.33	N	0.22	polymorphism	1	0.26	rs28457866	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10357	10357	T	A	MI.15599	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	299	100	L	Q	cTa/cAa	-1.32	0	0	probably_damaging	1	neutral	0.1	neutral	0.75	deleterious	-3.46	deleterious	-4.58	high_impact	4.21	0.71	neutral	0.46	neutral	4.14	23.80	deleterious	0.06	0.35	0.51	disease	0.71	disease	0.62	disease	0.67	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.73	deleterious	-3.43	low_impact	-0.34	medium_impact	2.75	high_impact	0.18	0.8	5.22	9.73	0.47	N	0.82	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8599	8599	C	G	MI.156	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	73	25	L	V	Cta/Gta	-4.27	0	0	probably_damaging	0.99	neutral	0.26	neutral	4.35	neutral	-0.27	neutral	-1.05	low_impact	0.92	0.88	neutral	0.86	neutral	1.84	15.24	deleterious	0.47	0.65	0.48	neutral	0.21	neutral	0.35	neutral	0.35	neutral	3	0.99	deleterious	0.14	neutral	-2	neutral	0.70	deleterious	-2.65	low_impact	0.04	medium_impact	-0.31	medium_impact	0.70	0.9	10.18	13.06	0.43	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8420	8420	A	G	MI.1560	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	55	19	T	A	Aca/Gca	-10.05	0	0	probably_damaging	0.97	neutral	0.42	neutral	1.86	neutral	-1.17	deleterious	-3.31	low_impact	1.22	1	neutral	0.97	neutral	1.84	15.25	deleterious	0.64287435	0.85	0.52	disease	0.05	neutral	0.5	neutral	0.03	neutral	9	0.97	neutral	0.23	neutral	-2	neutral	0.70	deleterious	-2.19	low_impact	0.21	medium_impact	-0.05	medium_impact	0.38	0.85	NA	NA	0.46	N	0.25	polymorphism	1	0.13	rs375408733	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10357	10357	T	C	MI.15600	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	299	100	L	P	cTa/cCa	-1.32	0	0	probably_damaging	1	neutral	0.07	neutral	0.74	deleterious	-3.94	deleterious	-5.32	high_impact	4.21	0.6	damaging	0.33	neutral	3.97	23.60	deleterious	0.05	0.35	0.58	disease	0.85	disease	0.73	disease	0.78	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.82	deleterious	-3.43	low_impact	-0.43	medium_impact	2.75	high_impact	0.27	0.8	5.22	9.73	0.4	N	0.93	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10357	10357	T	G	MI.15601	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	299	100	L	R	cTa/cGa	-1.32	0	0	probably_damaging	1	neutral	0.11	neutral	0.75	deleterious	-3.32	deleterious	-4.63	high_impact	4.21	0.64	neutral	0.38	neutral	4.22	23.90	deleterious	0.04	0.35	0.49	neutral	0.84	disease	0.74	disease	0.77	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	-0.31	medium_impact	2.75	high_impact	0.17	0.8	5.22	9.73	0.46	N	0.85	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10359	10359	A	G	MI.15602	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	301	101	S	G	Agt/Ggt	-9.62	0	0	benign	0.02	neutral	0.3	neutral	1.52	neutral	2.21	neutral	2.8	neutral_impact	-1.92	0.86	neutral	0.95	neutral	-1.03	0.01	neutral	0.12	0.4	0.09	neutral	0.09	neutral	0.35	neutral	0.22	neutral	6	0.69	neutral	0.64	deleterious	-6	neutral	0.10	neutral	0.81	medium_impact	-0.01	medium_impact	-2.87	low_impact	0.49	0.8	NA	NA	0.37	N	0.02	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10359	10359	A	T	MI.15603	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	301	101	S	C	Agt/Tgt	-9.62	0	0	probably_damaging	0.96	neutral	0.05	neutral	0.84	deleterious	-3.71	deleterious	-3.51	medium_impact	2.42	0.62	neutral	0.37	neutral	3.39	23.00	deleterious	0.05	0.35	0.66	disease	0.77	disease	0.54	disease	0.72	disease	4	0.99	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-1.96	low_impact	-0.52	medium_impact	1.11	medium_impact	0.27	0.8	NA	NA	0.29	N	0.70	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10359	10359	A	C	MI.15604	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	301	101	S	R	Agt/Cgt	-9.62	0	0	possibly_damaging	0.89	neutral	0.09	neutral	0.85	neutral	-2.78	deleterious	-2.84	medium_impact	2.76	0.63	neutral	0.44	neutral	3.63	23.20	deleterious	0.03	0.35	0.59	disease	0.93	disease	0.69	disease	0.82	disease	6	0.97	neutral	0.1	neutral	0	NA	0.85	deleterious	-1.54	low_impact	-0.37	medium_impact	1.42	medium_impact	0.29	0.8	NA	NA	0.34	N	0.69	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10360	10360	G	A	MI.15605	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	302	101	S	N	aGt/aAt	2.37	0.99	0	possibly_damaging	0.61	neutral	0.13	neutral	0.86	neutral	-2.52	neutral	-0.9	medium_impact	2.76	0.66	neutral	0.54	neutral	1.94	15.84	deleterious	0.27	0.45	0.49	neutral	0.83	disease	0.55	disease	0.77	disease	5	0.87	neutral	0.26	neutral	0	NA	0.68	deleterious	-0.89	medium_impact	-0.27	medium_impact	1.42	medium_impact	0.35	0.8	NA	NA	0.56	P	0.41	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10360	10360	G	T	MI.15606	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	302	101	S	I	aGt/aTt	2.37	0.99	0	probably_damaging	0.92	neutral	0.39	neutral	0.85	neutral	-2.99	deleterious	-4.43	medium_impact	2.06	0.7	neutral	0.45	neutral	3.92	23.50	deleterious	0.04	0.35	0.66	disease	0.87	disease	0.57	disease	0.79	disease	6	0.92	neutral	0.24	neutral	1	deleterious	0.84	deleterious	-1.68	low_impact	0.08	medium_impact	0.78	medium_impact	0.25	0.8	NA	NA	0.44	N	0.85	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10360	10360	G	C	MI.15607	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	302	101	S	T	aGt/aCt	2.37	0.99	0	possibly_damaging	0.68	neutral	0.15	neutral	0.92	neutral	-0.87	neutral	-2.23	low_impact	1.72	0.68	neutral	0.53	neutral	1.78	14.87	neutral	0.17	0.45	0.36	neutral	0.5	neutral	0.55	disease	0.67	disease	3	0.87	neutral	0.24	neutral	-3	neutral	0.63	deleterious	-1.01	low_impact	-0.23	medium_impact	0.47	medium_impact	0.50	0.8	NA	NA	0.55	P	0.52	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10362	10362	C	G	MI.15608	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	304	102	L	V	Ctg/Gtg	-10.78	0	0	probably_damaging	1	neutral	0.51	neutral	0.72	neutral	-1.32	deleterious	-2.9	medium_impact	3.17	0.67	neutral	0.08	damaging	3.51	23.10	deleterious	0.24	0.45	0.5	disease	0.55	disease	0.65	disease	0.55	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.76	deleterious	-3.43	low_impact	0.2	medium_impact	1.8	medium_impact	0.49	0.8	NA	NA	0.25	N	0.89	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10362	10362	C	A	MI.15609	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	304	102	L	M	Ctg/Atg	-10.78	0	0	probably_damaging	1	neutral	0.22	neutral	0.58	deleterious	-3.19	neutral	-1.93	high_impact	3.69	0.75	neutral	0.12	damaging	3.79	23.40	deleterious	0.23	0.45	0.59	disease	0.55	disease	0.69	disease	0.57	disease	1	1	deleterious	0.11	neutral	2	deleterious	0.75	deleterious	-3.43	low_impact	-0.12	medium_impact	2.28	high_impact	0.41	0.8	NA	NA	0.35	N	0.91	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8420	8420	A	C	MI.1561	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	55	19	T	P	Aca/Cca	-10.05	0	0	probably_damaging	0.99	neutral	0.07	neutral	1.75	deleterious	-4.64	deleterious	-4.98	high_impact	3.56	0.99	neutral	0.29	neutral	3.30	22.90	deleterious	0.25879581	0.85	0.79	disease	0.44	neutral	0.76	disease	0.34	neutral	3	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-2.65	low_impact	-0.34	medium_impact	1.95	medium_impact	0.49	0.85	NA	NA	0.53	N	0.78	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10363	10363	T	G	MI.15610	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	305	102	L	R	cTg/cGg	-0.17	0	0	probably_damaging	1	neutral	0.34	neutral	0.54	deleterious	-4.53	deleterious	-5.79	high_impact	4.66	0.64	neutral	0.04	damaging	4.22	23.90	deleterious	0.01	0.35	0.83	disease	0.87	disease	0.8	disease	0.79	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.43	low_impact	0.03	medium_impact	3.16	high_impact	0.12	0.8	NA	NA	0.58	P	1.00	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10363	10363	T	A	MI.15611	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	305	102	L	Q	cTg/cAg	-0.17	0	0	probably_damaging	1	neutral	0.29	neutral	0.54	deleterious	-4.66	deleterious	-5.79	high_impact	4.66	0.66	neutral	0.05	damaging	4.10	23.70	deleterious	0.03	0.35	0.85	disease	0.77	disease	0.71	disease	0.76	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.43	low_impact	-0.03	medium_impact	3.16	high_impact	0.31	0.8	NA	NA	0.48	N	0.97	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10363	10363	T	C	MI.15612	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	305	102	L	P	cTg/cCg	-0.17	0	0	probably_damaging	1	neutral	0.2	neutral	0.53	deleterious	-5.11	deleterious	-6.75	high_impact	4.66	0.57	damaging	0.05	damaging	4.01	23.60	deleterious	0.02	0.35	0.87	disease	0.83	disease	0.8	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	-0.14	medium_impact	3.16	high_impact	0.37	0.8	NA	NA	0.52	P	0.99	polymorphism	1	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10365	10365	G	C	MI.15613	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	307	103	A	P	Gcc/Ccc	-3.17	0	0	possibly_damaging	0.86	neutral	0.19	neutral	0.9	neutral	-2.67	deleterious	-4.02	high_impact	3.71	0.6	damaging	0.29	neutral	3.63	23.20	deleterious	0.05	0.35	0.52	disease	0.91	disease	0.7	disease	0.8	disease	6	0.92	neutral	0.17	neutral	1	deleterious	0.79	deleterious	-1.43	low_impact	-0.16	medium_impact	2.29	high_impact	0.60	0.8	NA	NA	0.39	N	0.80	polymorphism	1	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10365	10365	G	A	MI.15614	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	307	103	A	T	Gcc/Acc	-3.17	0	0	benign	0.03	neutral	0.41	neutral	0.95	neutral	-0.76	deleterious	-2.54	medium_impact	2.4	0.88	neutral	0.85	neutral	1.18	11.66	neutral	0.17	0.45	0.28	neutral	0.48	neutral	0.38	neutral	0.47	neutral	1	0.56	neutral	0.69	deleterious	-3	neutral	0.16	neutral	0.65	medium_impact	0.1	medium_impact	1.09	medium_impact	0.75	0.85	NA	NA	0.4	N	0.03	polymorphism	1	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10365	10365	G	T	MI.15615	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	307	103	A	S	Gcc/Tcc	-3.17	0	0	benign	0.4	neutral	0.39	neutral	0.95	neutral	-0.81	neutral	-2.23	medium_impact	3.37	0.78	neutral	0.69	neutral	1.99	16.16	deleterious	0.22	0.45	0.25	neutral	0.59	disease	0.46	neutral	0.48	neutral	0	0.55	neutral	0.5	deleterious	-3	neutral	0.36	neutral	-0.56	medium_impact	0.08	medium_impact	1.98	medium_impact	0.52	0.8	NA	NA	0.39	N	0.23	polymorphism	1	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10366	10366	C	G	MI.15616	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	308	103	A	G	gCc/gGc	0.06	0	0	benign	0.03	neutral	0.41	neutral	0.92	neutral	-1.77	deleterious	-3.49	medium_impact	2.82	0.78	neutral	0.56	neutral	2.36	18.59	deleterious	0.2	0.45	0.43	neutral	0.62	disease	0.54	disease	0.68	disease	4	0.56	neutral	0.69	deleterious	-3	neutral	0.20	neutral	0.65	medium_impact	0.1	medium_impact	1.48	medium_impact	0.71	0.85	NA	NA	0.32	N	0.44	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10366	10366	C	A	MI.15617	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	308	103	A	D	gCc/gAc	0.06	0	0	possibly_damaging	0.73	neutral	0.19	neutral	0.9	deleterious	-3.2	deleterious	-4.81	high_impact	3.71	0.67	neutral	0.33	neutral	4.31	24.00	deleterious	0.04	0.35	0.46	neutral	0.87	disease	0.68	disease	0.79	disease	6	0.86	neutral	0.23	neutral	1	deleterious	0.73	deleterious	-1.11	low_impact	-0.16	medium_impact	2.29	high_impact	0.42	0.8	NA	NA	0.42	N	0.96	polymorphism	1	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10366	10366	C	T	MI.15618	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	308	103	A	V	gCc/gTc	0.06	0	0	benign	0.08	neutral	0.5	neutral	1.1	neutral	0.92	neutral	-2.45	low_impact	1.34	0.75	neutral	0.64	neutral	1.06	11.00	neutral	0.17	0.45	0.22	neutral	0.41	neutral	0.34	neutral	0.43	neutral	1	0.43	neutral	0.71	deleterious	-6	neutral	0.17	neutral	0.24	medium_impact	0.19	medium_impact	0.12	medium_impact	0.70	0.85	NA	NA	0.37	N	0.51	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10368	10368	T	C	MI.15619	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	310	104	Y	H	Tat/Cat	-10.32	0	0	probably_damaging	1	neutral	0.42	neutral	0.49	deleterious	-5.75	deleterious	-4.82	medium_impact	2.32	0.57	damaging	0.07	damaging	3.68	23.30	deleterious	0.09	0.35	0.35	neutral	0.69	disease	0.59	disease	0.47	neutral	1	1	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.11	medium_impact	1.02	medium_impact	0.12	0.8	NA	NA	0.21	N	0.98	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8421	8421	C	T	MI.1562	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	56	19	T	M	aCa/aTa	-0.8	0	0	probably_damaging	1	neutral	0.11	neutral	1.83	neutral	-1.52	deleterious	-4.83	medium_impact	2.87	1	neutral	0.36	neutral	3.78	23.40	deleterious	0.47136521	0.85	0.87	disease	0.24	neutral	0.63	disease	0.15	neutral	7	1	deleterious	0.06	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.22	medium_impact	1.36	medium_impact	0.72	0.85	NA	NA	0.55	P	0.76	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10368	10368	T	A	MI.15620	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	310	104	Y	N	Tat/Aat	-10.32	0	0	probably_damaging	1	neutral	0.23	neutral	0.43	deleterious	-7.34	deleterious	-8.69	high_impact	4	0.6	damaging	0.04	damaging	4.15	23.80	deleterious	0.08	0.35	0.73	disease	0.9	disease	0.65	disease	0.71	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	-0.1	medium_impact	2.56	high_impact	0.05	0.8	NA	NA	0.33	N	0.99	polymorphism	1	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10368	10368	T	G	MI.15621	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	310	104	Y	D	Tat/Gat	-10.32	0	0	probably_damaging	1	neutral	0.15	neutral	0.42	deleterious	-8.41	deleterious	-9.65	high_impact	4.7	0.58	damaging	0.04	damaging	4.10	23.70	deleterious	0.05	0.35	0.79	disease	0.91	disease	0.68	disease	0.75	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.88	deleterious	-3.43	low_impact	-0.23	medium_impact	3.2	high_impact	0.08	0.8	NA	NA	0.43	N	0.97	disease_causing	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10369	10369	A	G	MI.15622	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	311	104	Y	C	tAt/tGt	4.67	1	0	probably_damaging	1	neutral	0.13	neutral	0.42	deleterious	-8.59	deleterious	-8.7	high_impact	4.34	0.59	damaging	0.02	damaging	3.69	23.30	deleterious	0.08	0.35	0.88	disease	0.88	disease	0.71	disease	0.78	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.87	deleterious	-3.43	low_impact	-0.27	medium_impact	2.87	high_impact	0.06	0.8	NA	NA	0.56	P	1.00	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10369	10369	A	C	MI.15623	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	311	104	Y	S	tAt/tCt	4.67	1	0	probably_damaging	1	neutral	0.33	neutral	0.46	deleterious	-7.04	deleterious	-8.68	high_impact	4.34	0.59	damaging	0.06	damaging	3.95	23.60	deleterious	0.08	0.35	0.7	disease	0.86	disease	0.65	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	0.02	medium_impact	2.87	high_impact	0.08	0.8	NA	NA	0.55	P	0.98	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10369	10369	A	T	MI.15624	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	311	104	Y	F	tAt/tTt	4.67	1	0	probably_damaging	1	neutral	0.57	neutral	0.59	deleterious	-3.6	deleterious	-3.86	medium_impact	2.33	0.6	damaging	0.06	damaging	3.60	23.20	deleterious	0.14	0.4	0.31	neutral	0.83	disease	0.56	disease	0.61	disease	2	1	deleterious	0.29	neutral	1	deleterious	0.81	deleterious	-3.43	low_impact	0.26	medium_impact	1.03	medium_impact	0.28	0.8	NA	NA	0.45	N	0.81	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10371	10371	G	A	MI.15625	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	313	105	E	K	Gag/Aag	-5.47	0	0	probably_damaging	1	neutral	0.24	neutral	0.69	neutral	-2.12	deleterious	-3.86	high_impact	4.26	0.39	damaging	0.28	damaging	4.59	24.40	deleterious	0.05	0.35	0.63	disease	0.86	disease	0.71	disease	0.73	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.43	low_impact	-0.09	medium_impact	2.8	high_impact	0.80	0.85	NA	NA	0.64	P	0.99	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10371	10371	G	C	MI.15626	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	313	105	E	Q	Gag/Cag	-5.47	0	0	probably_damaging	1	neutral	0.23	neutral	0.66	neutral	-2.66	deleterious	-2.9	high_impact	4.82	0.41	damaging	0.51	neutral	3.47	23.00	deleterious	0.13	0.4	0.68	disease	0.75	disease	0.63	disease	0.66	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.84	deleterious	-3.43	low_impact	-0.1	medium_impact	3.31	high_impact	0.71	0.85	NA	NA	0.73	P	0.90	polymorphism	1	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10372	10372	A	C	MI.15627	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	314	105	E	A	gAg/gCg	7.44	1	0	probably_damaging	1	neutral	0.37	neutral	0.76	neutral	-1.36	deleterious	-5.79	medium_impact	2.66	0.46	damaging	0.5	neutral	3.80	23.40	deleterious	0.05	0.35	0.66	disease	0.74	disease	0.64	disease	0.66	disease	3	1	deleterious	0.19	neutral	1	deleterious	0.85	deleterious	-3.43	low_impact	0.06	medium_impact	1.33	medium_impact	0.39	0.8	NA	NA	0.67	P	0.76	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10372	10372	A	G	MI.15628	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	314	105	E	G	gAg/gGg	7.44	1	0	probably_damaging	1	neutral	0.34	neutral	0.62	deleterious	-3.63	deleterious	-6.76	high_impact	4.82	0.37	damaging	0.53	neutral	4.43	24.20	deleterious	0.03	0.35	0.68	disease	0.76	disease	0.66	disease	0.67	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	0.03	medium_impact	3.31	high_impact	0.28	0.8	NA	NA	0.79	P	0.61	polymorphism	1	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10372	10372	A	T	MI.15629	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	314	105	E	V	gAg/gTg	7.44	1	0	probably_damaging	1	neutral	0.39	neutral	0.66	neutral	-2.54	deleterious	-6.76	medium_impact	3.1	0.36	damaging	0.36	neutral	4.31	24.00	deleterious	0.03	0.35	0.8	disease	0.86	disease	0.68	disease	0.74	disease	5	1	deleterious	0.2	neutral	1	deleterious	0.89	deleterious	-3.43	low_impact	0.08	medium_impact	1.73	medium_impact	0.26	0.8	NA	NA	0.78	P	0.84	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8421	8421	C	A	MI.1563	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	56	19	T	K	aCa/aAa	-0.8	0	0	probably_damaging	0.99	neutral	0.05	neutral	1.75	deleterious	-4.03	deleterious	-4.96	high_impact	3.56	1	neutral	0.37	neutral	4.16	23.80	deleterious	0.23790843	0.85	0.76	disease	0.42	neutral	0.75	disease	0.3	neutral	4	1	deleterious	0.03	neutral	2	deleterious	0.83	deleterious	-2.65	low_impact	-0.43	medium_impact	1.95	medium_impact	0.71	0.85	NA	NA	0.56	N	0.68	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10373	10373	G	T	MI.15630	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	315	105	E	D	gaG/gaT	8.59	1	0.03	probably_damaging	1	neutral	0.15	neutral	0.66	neutral	-2.68	deleterious	-2.9	high_impact	4.26	0.53	damaging	0.42	neutral	3.96	23.60	deleterious	0.19	0.45	0.5	neutral	0.75	disease	0.57	disease	0.65	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	-0.23	medium_impact	2.8	high_impact	0.71	0.85	NA	NA	0.7	P	0.86	polymorphism	0.99	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10373	10373	G	C	MI.15631	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	315	105	E	D	gaG/gaC	8.59	1	0.03	probably_damaging	1	neutral	0.15	neutral	0.66	neutral	-2.68	deleterious	-2.9	high_impact	4.26	0.53	damaging	0.42	neutral	3.78	23.40	deleterious	0.19	0.45	0.5	neutral	0.75	disease	0.57	disease	0.65	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.43	low_impact	-0.23	medium_impact	2.8	high_impact	0.71	0.85	NA	NA	0.69	P	0.86	polymorphism	0.99	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10374	10374	T	C	MI.15632	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	316	106	W	R	Tga/Cga	0.52	0.99	0	probably_damaging	1	neutral	0.34	neutral	0.72	deleterious	-4.41	deleterious	-13.48	high_impact	4.48	0.62	neutral	0.03	damaging	3.70	23.30	deleterious	0.03	0.35	0.86	disease	0.89	disease	0.79	disease	0.83	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.43	low_impact	0.03	medium_impact	3	high_impact	0.06	0.8	NA	NA	0.59	P	0.97	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10374	10374	T	G	MI.15633	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	316	106	W	G	Tga/Gga	0.52	0.99	0	probably_damaging	1	neutral	0.34	neutral	0.72	deleterious	-4.82	deleterious	-12.54	high_impact	4.83	0.54	damaging	0.04	damaging	3.99	23.60	deleterious	0.04	0.35	0.82	disease	0.83	disease	0.76	disease	0.79	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	0.03	medium_impact	3.32	high_impact	0.09	0.8	NA	NA	0.54	P	0.97	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10375	10375	G	T	MI.15634	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	317	106	W	L	tGa/tTa	5.83	1	0	probably_damaging	1	neutral	0.66	neutral	0.88	neutral	-2.33	deleterious	-12.54	medium_impact	3.08	0.55	damaging	0.02	damaging	4.38	24.10	deleterious	0.06	0.35	0.74	disease	0.86	disease	0.73	disease	0.74	disease	5	1	deleterious	0.33	neutral	1	deleterious	0.87	deleterious	-3.43	low_impact	0.35	medium_impact	1.72	medium_impact	0.07	0.8	NA	NA	0.49	N	0.97	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10375	10375	G	C	MI.15635	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	317	106	W	S	tGa/tCa	5.83	1	0	probably_damaging	1	neutral	0.4	neutral	0.75	deleterious	-3.74	deleterious	-13.47	high_impact	4.48	0.55	damaging	0.04	damaging	4.10	23.70	deleterious	0.04	0.35	0.86	disease	0.88	disease	0.74	disease	0.81	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.89	deleterious	-3.43	low_impact	0.09	medium_impact	3	high_impact	0.07	0.8	NA	NA	0.6	P	0.95	disease_causing	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10376	10376	A	T	MI.15636	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	318	106	W	C	tgA/tgT	9.29	1	0	probably_damaging	1	neutral	0.17	neutral	0.71	deleterious	-5.39	deleterious	-12.55	high_impact	4.48	0.54	damaging	0.02	damaging	4.21	23.90	deleterious	0.03	0.35	0.93	disease	0.87	disease	0.77	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.43	low_impact	-0.19	medium_impact	3	high_impact	0.12	0.8	NA	NA	0.6	P	0.98	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10376	10376	A	C	MI.15637	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	318	106	W	C	tgA/tgC	9.29	1	0	probably_damaging	1	neutral	0.17	neutral	0.71	deleterious	-5.39	deleterious	-12.55	high_impact	4.48	0.54	damaging	0.02	damaging	4.09	23.70	deleterious	0.03	0.35	0.93	disease	0.87	disease	0.77	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.43	low_impact	-0.19	medium_impact	3	high_impact	0.12	0.8	NA	NA	0.59	P	0.98	polymorphism	1	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10377	10377	C	G	MI.15638	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	319	107	L	V	Cta/Gta	3.29	0.99	0	benign	0.12	neutral	0.52	neutral	0.99	neutral	-0.11	neutral	-0.41	low_impact	1.08	0.81	neutral	0.98	neutral	0.26	5.30	deleterious	0.27	0.45	0.22	neutral	0.12	neutral	0.13	neutral	0.3	neutral	4	0.39	neutral	0.7	deleterious	-6	neutral	0.10	neutral	0.06	medium_impact	0.21	medium_impact	-0.12	medium_impact	0.26	0.8	NA	NA	0.53	P	0.29	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10377	10377	C	A	MI.15639	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	319	107	L	M	Cta/Ata	3.29	0.99	0	possibly_damaging	0.7	neutral	0.25	neutral	0.95	neutral	-1.38	neutral	0.07	neutral_impact	0.56	0.8	neutral	0.96	neutral	1.85	15.30	deleterious	0.22	0.45	0.39	neutral	0.1	neutral	0.14	neutral	0.33	neutral	3	0.8	neutral	0.28	neutral	-3	neutral	0.46	deleterious	-1.05	low_impact	-0.08	medium_impact	-0.6	medium_impact	0.51	0.8	NA	NA	0.59	P	0.46	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8423	8423	C	G	MI.1564	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	58	20	L	V	Cta/Gta	-12.6	0	0	probably_damaging	0.97	neutral	0.09	neutral	1.22	deleterious	-8.3	deleterious	-2.99	high_impact	3.8	0.98	neutral	0.1	damaging	3.25	22.80	deleterious	0.41111942	0.85	0.55	disease	0.15	neutral	0.71	disease	0.22	neutral	6	0.99	deleterious	0.06	neutral	2	deleterious	0.74	deleterious	-2.19	low_impact	-0.28	medium_impact	2.16	high_impact	0.70	0.85	NA	NA	0.46	N	0.46	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10378	10378	T	C	MI.15640	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	320	107	L	P	cTa/cCa	-7.55	0	0	benign	0.29	neutral	0.22	neutral	0.92	neutral	-1.24	neutral	-2.44	medium_impact	2.71	0.62	neutral	0.37	neutral	2.27	17.96	deleterious	0.04	0.35	0.49	neutral	0.69	disease	0.48	neutral	0.49	neutral	0	0.74	neutral	0.47	neutral	-3	neutral	0.33	neutral	-0.37	medium_impact	-0.12	medium_impact	1.38	medium_impact	0.08	0.8	NA	NA	0.33	N	0.60	polymorphism	1	0.62	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10378	10378	T	G	MI.15641	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	320	107	L	R	cTa/cGa	-7.55	0	0	benign	0.23	neutral	0.38	neutral	1	neutral	1.87	neutral	-2.05	neutral_impact	0.5	0.74	neutral	0.44	neutral	1.42	12.91	neutral	0.08	0.35	0.34	neutral	0.55	disease	0.39	neutral	0.5	neutral	0	0.54	neutral	0.58	deleterious	-6	neutral	0.26	neutral	-0.24	medium_impact	0.07	medium_impact	-0.65	medium_impact	0.15	0.8	NA	NA	0.34	N	0.46	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10378	10378	T	A	MI.15642	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	320	107	L	Q	cTa/cAa	-7.55	0	0	benign	0.29	neutral	0.36	neutral	0.98	neutral	0.38	neutral	-1.68	low_impact	1.52	0.76	neutral	0.51	neutral	1.53	13.49	neutral	0.1	0.4	0.34	neutral	0.35	neutral	0.32	neutral	0.46	neutral	1	0.57	neutral	0.54	deleterious	-6	neutral	0.22	neutral	-0.37	medium_impact	0.05	medium_impact	0.29	medium_impact	0.16	0.8	NA	NA	0.38	N	0.46	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10380	10380	C	G	MI.15643	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	322	108	Q	E	Caa/Gaa	-15.39	0	0	probably_damaging	1	neutral	0.35	neutral	1.08	neutral	0.43	neutral	-2.06	low_impact	0.9	0.76	neutral	0.75	neutral	3.16	22.60	deleterious	0.5	0.6	0.2	neutral	0.5	neutral	0.35	neutral	0.42	neutral	2	1	deleterious	0.18	neutral	-2	neutral	0.73	deleterious	-3.43	low_impact	0.04	medium_impact	-0.28	medium_impact	0.62	0.8	NA	NA	0.36	N	0.37	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10380	10380	C	A	MI.15644	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	322	108	Q	K	Caa/Aaa	-15.39	0	0	probably_damaging	1	neutral	0.28	neutral	1.12	neutral	2.12	deleterious	-2.85	low_impact	1.29	0.73	neutral	0.44	neutral	4.04	23.70	deleterious	0.45	0.55	0.32	neutral	0.64	disease	0.46	neutral	0.45	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.77	deleterious	-3.43	low_impact	-0.04	medium_impact	0.07	medium_impact	0.46	0.8	NA	NA	0.39	N	0.88	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10381	10381	A	C	MI.15645	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	323	108	Q	P	cAa/cCa	3.52	0.99	0	probably_damaging	1	neutral	0.19	neutral	0.93	neutral	-1.88	deleterious	-4.85	high_impact	3.96	0.62	neutral	0.34	neutral	3.24	22.80	deleterious	0.08	0.35	0.63	disease	0.79	disease	0.66	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.43	low_impact	-0.16	medium_impact	2.52	high_impact	0.40	0.8	NA	NA	0.6	P	0.89	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10381	10381	A	T	MI.15646	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	323	108	Q	L	cAa/cTa	3.52	0.99	0	probably_damaging	1	neutral	0.68	neutral	0.97	neutral	-1.13	deleterious	-5.86	medium_impact	2.54	0.67	neutral	0.41	neutral	3.69	23.30	deleterious	0.16	0.45	0.58	disease	0.78	disease	0.51	disease	0.62	disease	2	1	deleterious	0.34	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.37	medium_impact	1.22	medium_impact	0.32	0.8	NA	NA	0.41	N	0.90	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10381	10381	A	G	MI.15647	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	323	108	Q	R	cAa/cGa	3.52	0.99	0	probably_damaging	1	neutral	0.33	neutral	0.98	neutral	0.73	deleterious	-3	medium_impact	2.12	0.73	neutral	0.35	neutral	3.33	22.90	deleterious	0.56	0.6	0.39	neutral	0.69	disease	0.5	neutral	0.47	neutral	1	1	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-3.43	low_impact	0.02	medium_impact	0.84	medium_impact	0.28	0.8	NA	NA	0.48	N	0.74	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10382	10382	A	T	MI.15648	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	324	108	Q	H	caA/caT	8.59	1	0	probably_damaging	1	neutral	0.51	neutral	0.94	neutral	-1.27	deleterious	-3.71	medium_impact	3.26	0.73	neutral	0.55	neutral	3.61	23.20	deleterious	0.33	0.5	0.59	disease	0.59	disease	0.5	neutral	0.46	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.2	medium_impact	1.88	medium_impact	0.40	0.8	NA	NA	0.62	P	0.85	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10382	10382	A	C	MI.15649	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	324	108	Q	H	caA/caC	8.59	1	0	probably_damaging	1	neutral	0.51	neutral	0.94	neutral	-1.27	deleterious	-3.71	medium_impact	3.26	0.73	neutral	0.55	neutral	3.48	23.10	deleterious	0.33	0.5	0.59	disease	0.59	disease	0.5	neutral	0.46	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.43	low_impact	0.2	medium_impact	1.88	medium_impact	0.40	0.8	NA	NA	0.62	P	0.85	polymorphism	1	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8423	8423	C	A	MI.1565	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	58	20	L	M	Cta/Ata	-12.6	0	0	probably_damaging	1	neutral	0.06	neutral	1.19	deleterious	-8.54	neutral	-2	medium_impact	3.25	0.98	neutral	0.09	damaging	3.60	23.20	deleterious	0.34020157	0.85	0.63	disease	0.18	neutral	0.68	disease	0.24	neutral	5	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.38	medium_impact	1.69	medium_impact	0.61	0.85	NA	NA	0.44	N	0.61	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10383	10383	A	G	MI.15650	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	325	109	K	E	Aaa/Gaa	3.98	1	0	probably_damaging	1	neutral	0.33	neutral	0.97	neutral	-0.87	deleterious	-2.81	medium_impact	2.68	0.86	neutral	0.72	neutral	2.47	19.25	deleterious	0.23	0.45	0.34	neutral	0.66	disease	0.61	disease	0.64	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.77	deleterious	-3.43	low_impact	0.02	medium_impact	1.35	medium_impact	0.53	0.8	NA	NA	0.54	P	0.86	polymorphism	1	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10383	10383	A	C	MI.15651	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	325	109	K	Q	Aaa/Caa	3.98	1	0	probably_damaging	1	neutral	0.37	neutral	0.92	neutral	-1.62	deleterious	-2.98	medium_impact	2.52	0.79	neutral	0.13	damaging	2.19	17.42	deleterious	0.34	0.5	0.4	neutral	0.39	neutral	0.58	disease	0.46	neutral	1	1	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-3.43	low_impact	0.06	medium_impact	1.2	medium_impact	0.42	0.8	NA	NA	0.49	N	0.86	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10384	10384	A	C	MI.15652	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	326	109	K	T	aAa/aCa	3.29	1	0	probably_damaging	1	neutral	0.39	neutral	0.91	neutral	-1.99	deleterious	-4.67	medium_impact	3.15	0.76	neutral	0.14	damaging	2.40	18.82	deleterious	0.16	0.45	0.43	neutral	0.4	neutral	0.6	disease	0.46	neutral	1	1	deleterious	0.2	neutral	1	deleterious	0.73	deleterious	-3.43	low_impact	0.08	medium_impact	1.78	medium_impact	0.33	0.8	NA	NA	0.48	N	0.81	polymorphism	1	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10384	10384	A	T	MI.15653	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	326	109	K	M	aAa/aTa	3.29	1	0	probably_damaging	1	neutral	0.22	neutral	0.87	deleterious	-3.75	deleterious	-4.87	medium_impact	3.49	0.78	neutral	0.13	damaging	3.83	23.40	deleterious	0.09	0.35	0.71	disease	0.48	neutral	0.6	disease	0.65	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-3.43	low_impact	-0.12	medium_impact	2.09	high_impact	0.35	0.8	NA	NA	0.54	P	0.54	polymorphism	1	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10385	10385	A	T	MI.15654	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	327	109	K	N	aaA/aaT	5.83	1	0	probably_damaging	1	neutral	0.36	neutral	0.94	neutral	-1.69	deleterious	-3.61	low_impact	1.31	0.75	neutral	0.13	damaging	2.35	18.47	deleterious	0.38	0.5	0.43	neutral	0.6	disease	0.49	neutral	0.48	neutral	0	1	deleterious	0.18	neutral	-2	neutral	0.77	deleterious	-3.43	low_impact	0.05	medium_impact	0.09	medium_impact	0.37	0.8	NA	NA	0.53	N	0.71	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10385	10385	A	C	MI.15655	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	327	109	K	N	aaA/aaC	5.83	1	0	probably_damaging	1	neutral	0.36	neutral	0.94	neutral	-1.69	deleterious	-3.61	low_impact	1.31	0.75	neutral	0.13	damaging	2.17	17.31	deleterious	0.38	0.5	0.43	neutral	0.6	disease	0.49	neutral	0.48	neutral	0	1	deleterious	0.18	neutral	-2	neutral	0.77	deleterious	-3.43	low_impact	0.05	medium_impact	0.09	medium_impact	0.37	0.8	NA	NA	0.53	N	0.71	polymorphism	1	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10386	10386	G	C	MI.15656	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	328	110	G	R	Gga/Cga	-0.4	0.32	0	probably_damaging	1	neutral	0.39	neutral	0.98	neutral	-0.6	deleterious	-7.28	medium_impact	3.42	0.66	neutral	0.04	damaging	4.29	24.00	deleterious	0.12	0.4	0.49	neutral	0.67	disease	0.63	disease	0.66	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.43	low_impact	0.08	medium_impact	2.03	high_impact	0.50	0.8	NA	NA	0.28	N	1.00	polymorphism	1	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10386	10386	G	T	MI.15657	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	328	110	G	W	Gga/Tga	-0.4	0.32	0	probably_damaging	1	neutral	0.29	neutral	0.94	neutral	-2.88	deleterious	-7.36	high_impact	3.76	0.67	neutral	0.04	damaging	4.77	24.70	deleterious	0.13	0.4	0.85	disease	0.76	disease	0.66	disease	0.76	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	-0.03	medium_impact	2.34	high_impact	0.07	0.8	NA	NA	0.33	N	1.00	polymorphism	1	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10387	10387	G	T	MI.15658	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	329	110	G	V	gGa/gTa	6.06	1	0	probably_damaging	1	neutral	0.56	neutral	1.1	neutral	1.34	deleterious	-8.22	medium_impact	2.19	0.61	neutral	0.04	damaging	4.12	23.80	deleterious	0.13	0.4	0.38	neutral	0.62	disease	0.57	disease	0.64	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.77	deleterious	-3.43	low_impact	0.25	medium_impact	0.9	medium_impact	0.04	0.8	NA	NA	0.41	N	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10387	10387	G	A	MI.15659	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	329	110	G	E	gGa/gAa	6.06	1	0	probably_damaging	1	neutral	0.42	neutral	0.99	neutral	-0.2	deleterious	-7.25	high_impact	3.76	0.67	neutral	0.06	damaging	4.29	24.00	deleterious	0.14	0.4	0.43	neutral	0.66	disease	0.62	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.79	deleterious	-3.43	low_impact	0.11	medium_impact	2.34	high_impact	0.15	0.8	NA	NA	0.55	P	1.00	polymorphism	1	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8424	8424	T	A	MI.1566	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	59	20	L	Q	cTa/cAa	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	1.17	deleterious	-11.19	deleterious	-5.99	high_impact	3.8	0.97	neutral	0.06	damaging	4.08	23.70	deleterious	0.20000037	0.85	0.87	disease	0.42	neutral	0.7	disease	0.31	neutral	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	2.16	high_impact	0.62	0.85	NA	NA	0.48	N	0.91	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10387	10387	G	C	MI.15660	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	329	110	G	A	gGa/gCa	6.06	1	0	probably_damaging	1	neutral	0.59	neutral	1.17	neutral	1.89	deleterious	-5.39	low_impact	1.27	0.69	neutral	0.16	damaging	3.42	23.00	deleterious	0.27	0.45	0.28	neutral	0.3	neutral	0.31	neutral	0.39	neutral	2	1	deleterious	0.3	neutral	-2	neutral	0.72	deleterious	-3.43	low_impact	0.28	medium_impact	0.06	medium_impact	0.33	0.8	NA	NA	0.48	N	0.81	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10389	10389	T	G	MI.15661	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	331	111	L	V	Tta/Gta	-8.7	0	0	probably_damaging	1	neutral	0.58	neutral	0.1	deleterious	-3.97	deleterious	-2.78	high_impact	3.78	0.42	damaging	0.02	damaging	3.78	23.40	deleterious	0.13	0.4	0.4	neutral	0.21	neutral	0.71	disease	0.43	neutral	1	1	deleterious	0.29	neutral	2	deleterious	0.72	deleterious	-3.43	low_impact	0.27	medium_impact	2.36	high_impact	0.42	0.8	NA	NA	0.46	N	0.89	polymorphism	1	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10389	10389	T	A	MI.15662	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	331	111	L	M	Tta/Ata	-8.7	0	0	probably_damaging	1	neutral	0.25	neutral	0.11	deleterious	-4.81	neutral	-1.86	high_impact	4.01	0.49	damaging	0.03	damaging	3.96	23.60	deleterious	0.13	0.4	0.53	disease	0.21	neutral	0.62	disease	0.4	neutral	2	1	deleterious	0.13	neutral	2	deleterious	0.72	deleterious	-3.43	low_impact	-0.08	medium_impact	2.57	high_impact	0.43	0.8	NA	NA	0.39	N	0.91	polymorphism	1	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10390	10390	T	C	MI.15663	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	332	111	L	S	tTa/tCa	-0.4	0	0	probably_damaging	1	neutral	0.58	neutral	-0.01	deleterious	-7.17	deleterious	-5.56	high_impact	4.27	0.43	damaging	0.03	damaging	4.10	23.70	deleterious	0.03	0.35	0.69	disease	0.39	neutral	0.7	disease	0.59	disease	2	1	deleterious	0.29	neutral	2	deleterious	0.80	deleterious	-3.43	low_impact	0.27	medium_impact	2.81	high_impact	0.20	0.8	NA	NA	0.48	N	0.97	polymorphism	1	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10390	10390	T	G	MI.15664	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	332	111	L	W	tTa/tGa	-0.4	0	0	probably_damaging	1	neutral	0.22	neutral	-0.03	deleterious	-8.47	deleterious	-5.58	high_impact	4.82	0.47	damaging	0.01	damaging	4.12	23.80	deleterious	0.05	0.35	0.89	disease	0.41	neutral	0.73	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	-0.12	medium_impact	3.31	high_impact	0.23	0.8	NA	NA	0.56	P	0.98	polymorphism	1	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10391	10391	A	C	MI.15665	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	333	111	L	F	ttA/ttC	7.44	0.99	0	probably_damaging	1	neutral	0.72	neutral	0.05	deleterious	-4.49	deleterious	-3.71	medium_impact	3.29	0.45	damaging	0.01	damaging	3.82	23.40	deleterious	0.12	0.4	0.56	disease	0.29	neutral	0.7	disease	0.55	disease	1	1	deleterious	0.36	neutral	1	deleterious	0.76	deleterious	-3.43	low_impact	0.42	medium_impact	1.91	medium_impact	0.49	0.8	NA	NA	0.6	P	0.99	polymorphism	1	0.62	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10391	10391	A	T	MI.15666	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	333	111	L	F	ttA/ttT	7.44	0.99	0	probably_damaging	1	neutral	0.72	neutral	0.05	deleterious	-4.49	deleterious	-3.71	medium_impact	3.29	0.45	damaging	0.01	damaging	3.90	23.50	deleterious	0.12	0.4	0.56	disease	0.29	neutral	0.7	disease	0.55	disease	1	1	deleterious	0.36	neutral	1	deleterious	0.76	deleterious	-3.43	low_impact	0.42	medium_impact	1.91	medium_impact	0.49	0.8	NA	NA	0.6	P	0.99	polymorphism	1	0.62	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10392	10392	G	C	MI.15667	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	334	112	D	H	Gac/Cac	-0.17	0.89	0	probably_damaging	0.96	neutral	0.55	neutral	0.87	neutral	-2.27	neutral	-2.49	medium_impact	2.56	0.71	neutral	0.5	neutral	3.82	23.40	deleterious	0.27	0.45	0.53	disease	0.16	neutral	0.51	disease	0.3	neutral	4	0.96	neutral	0.3	neutral	1	deleterious	0.71	deleterious	-1.96	low_impact	0.24	medium_impact	1.24	medium_impact	0.61	0.8	NA	NA	0.32	N	0.63	polymorphism	1	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10392	10392	G	A	MI.15668	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	334	112	D	N	Gac/Aac	-0.17	0.89	0	benign	0.08	neutral	0.38	neutral	0.92	neutral	-0.59	neutral	-2.23	low_impact	1.02	0.72	neutral	0.56	neutral	4.10	23.70	deleterious	0.84	0.85	0.19	neutral	0.27	neutral	0.32	neutral	0.39	neutral	2	0.57	neutral	0.65	deleterious	-6	neutral	0.18	neutral	0.24	medium_impact	0.07	medium_impact	-0.17	medium_impact	0.70	0.85	NA	NA	0.42	N	0.47	polymorphism	0.99	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10392	10392	G	T	MI.15669	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	334	112	D	Y	Gac/Tac	-0.17	0.89	0	probably_damaging	0.98	neutral	1	neutral	0.85	deleterious	-3.14	deleterious	-4.35	medium_impact	2.15	0.71	neutral	0.56	neutral	4.14	23.80	deleterious	0.11	0.4	0.7	disease	0.38	neutral	0.51	disease	0.62	disease	2	0.97	neutral	0.51	deleterious	1	deleterious	0.79	deleterious	-2.24	low_impact	1.85	high_impact	0.86	medium_impact	0.09	0.8	NA	NA	0.27	N	0.93	polymorphism	1	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8424	8424	T	G	MI.1567	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	59	20	L	R	cTa/cGa	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	1.17	deleterious	-11.06	deleterious	-5.99	high_impact	3.8	0.97	neutral	0.04	damaging	3.99	23.60	deleterious	0.18482793	0.85	0.86	disease	0.55	disease	0.78	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.16	high_impact	0.43	0.85	NA	NA	0.5	N	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10393	10393	A	C	MI.15670	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	335	112	D	A	gAc/gCc	7.44	1	0	possibly_damaging	0.64	neutral	0.63	neutral	0.94	neutral	-0.81	deleterious	-3.41	medium_impact	2.7	0.71	neutral	0.67	neutral	3.45	23.00	deleterious	0.31	0.45	0.37	neutral	0.24	neutral	0.47	neutral	0.41	neutral	2	0.57	neutral	0.5	deleterious	0	NA	0.54	deleterious	-0.94	medium_impact	0.32	medium_impact	1.37	medium_impact	0.38	0.8	NA	NA	0.6	P	0.71	polymorphism	0.89	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10393	10393	A	T	MI.15671	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	335	112	D	V	gAc/gTc	7.44	1	0	probably_damaging	0.9	neutral	0.55	neutral	0.87	neutral	-2.14	deleterious	-4.35	medium_impact	2.7	0.72	neutral	0.62	neutral	3.80	23.40	deleterious	0.13	0.4	0.6	disease	0.3	neutral	0.47	neutral	0.57	disease	1	0.89	neutral	0.33	neutral	1	deleterious	0.70	deleterious	-1.58	low_impact	0.24	medium_impact	1.37	medium_impact	0.12	0.8	NA	NA	0.6	P	0.86	polymorphism	0.78	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10393	10393	A	G	MI.15672	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	335	112	D	G	gAc/gGc	7.44	1	0	possibly_damaging	0.64	neutral	0.4	neutral	0.87	neutral	-1.93	deleterious	-4.08	medium_impact	2.9	0.78	neutral	0.53	neutral	3.87	23.50	deleterious	0.28	0.45	0.4	neutral	0.26	neutral	0.47	neutral	0.41	neutral	2	0.67	neutral	0.38	neutral	0	NA	0.57	deleterious	-0.94	medium_impact	0.09	medium_impact	1.55	medium_impact	0.33	0.8	NA	NA	0.66	P	0.81	polymorphism	0.96	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10394	10394	C	G	MI.15673	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	336	112	D	E	gaC/gaG	8.59	1	0	benign	0.05	neutral	0.45	neutral	1.06	neutral	0.71	neutral	1.88	neutral_impact	-0.94	0.83	neutral	0.93	neutral	-0.48	0.25	neutral	0.55	0.6	0.09	neutral	0.02	neutral	0.13	neutral	0.23	neutral	5	0.51	neutral	0.7	deleterious	-6	neutral	0.11	neutral	0.44	medium_impact	0.14	medium_impact	-1.97	low_impact	0.57	0.8	NA	NA	0.59	P	0.06	disease_causing	0.68	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10394	10394	C	A	MI.15674	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	336	112	D	E	gaC/gaA	8.59	1	0	benign	0.05	neutral	0.45	neutral	1.06	neutral	0.71	neutral	1.88	neutral_impact	-0.94	0.83	neutral	0.93	neutral	-0.27	0.79	neutral	0.55	0.6	0.09	neutral	0.02	neutral	0.13	neutral	0.23	neutral	5	0.51	neutral	0.7	deleterious	-6	neutral	0.11	neutral	0.44	medium_impact	0.14	medium_impact	-1.97	low_impact	0.57	0.8	NA	NA	0.59	P	0.06	disease_causing	0.68	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10395	10395	T	G	MI.15675	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	337	113	W	G	Tga/Gga	0.06	0.92	0	probably_damaging	1	neutral	0.57	neutral	0.12	deleterious	-7.74	deleterious	-12.13	high_impact	4.72	0.54	damaging	0.04	damaging	4.16	23.80	deleterious	0.05	0.35	0.82	disease	0.46	neutral	0.72	disease	0.65	disease	3	1	deleterious	0.29	neutral	2	deleterious	0.82	deleterious	-3.43	low_impact	0.26	medium_impact	3.22	high_impact	0.11	0.8	NA	NA	0.49	P	0.98	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10395	10395	T	C	MI.15676	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	337	113	W	R	Tga/Cga	0.06	0.92	0	probably_damaging	1	neutral	0.69	neutral	0.14	deleterious	-7.7	deleterious	-13.06	high_impact	4.17	0.62	neutral	0.03	damaging	3.87	23.50	deleterious	0.04	0.35	0.86	disease	0.58	disease	0.74	disease	0.76	disease	5	1	deleterious	0.35	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	0.38	medium_impact	2.72	high_impact	0.12	0.8	NA	NA	0.47	N	0.97	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10396	10396	G	C	MI.15677	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	338	113	W	S	tGa/tCa	5.83	1	0	probably_damaging	1	neutral	0.89	neutral	0.14	deleterious	-7.3	deleterious	-13.06	high_impact	4.72	0.55	damaging	0.04	damaging	4.24	23.90	deleterious	0.05	0.35	0.86	disease	0.6	disease	0.72	disease	0.75	disease	5	1	deleterious	0.45	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	0.69	medium_impact	3.22	high_impact	0.13	0.8	NA	NA	0.55	P	0.96	disease_causing	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10396	10396	G	T	MI.15678	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	338	113	W	L	tGa/tTa	5.83	1	0	probably_damaging	1	neutral	0.81	neutral	0.22	deleterious	-5.64	deleterious	-12.13	high_impact	3.92	0.55	damaging	0.02	damaging	4.42	24.20	deleterious	0.06	0.35	0.74	disease	0.46	neutral	0.71	disease	0.6	disease	2	1	deleterious	0.41	neutral	2	deleterious	0.81	deleterious	-3.43	low_impact	0.54	medium_impact	2.49	high_impact	0.09	0.8	NA	NA	0.54	P	0.97	polymorphism	1	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10397	10397	A	C	MI.15679	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	339	113	W	C	tgA/tgC	7.21	1	0.08	probably_damaging	1	neutral	0.19	neutral	0.12	deleterious	-8.89	deleterious	-12.13	high_impact	4.72	0.54	damaging	0.02	damaging	4.25	23.90	deleterious	0.05	0.35	0.93	disease	0.57	disease	0.73	disease	0.79	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	-0.16	medium_impact	3.22	high_impact	0.11	0.8	NA	NA	0.54	P	0.98	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8424	8424	T	C	MI.1568	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	59	20	L	P	cTa/cCa	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	1.16	deleterious	-11.31	deleterious	-6.99	high_impact	3.8	0.97	neutral	0.04	damaging	3.83	23.40	deleterious	0.25207871	0.85	0.89	disease	0.46	neutral	0.78	disease	0.42	neutral	2	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.16	high_impact	0.58	0.85	NA	NA	0.49	N	0.97	polymorphism	0.85	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10397	10397	A	T	MI.15680	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	339	113	W	C	tgA/tgT	7.21	1	0.08	probably_damaging	1	neutral	0.19	neutral	0.12	deleterious	-8.89	deleterious	-12.13	high_impact	4.72	0.54	damaging	0.02	damaging	4.37	24.10	deleterious	0.05	0.35	0.93	disease	0.57	disease	0.73	disease	0.79	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.43	low_impact	-0.16	medium_impact	3.22	high_impact	0.11	0.8	NA	NA	0.53	P	0.98	polymorphism	1	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10398	10398	A	G	MI.15681	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	340	114	T	A	Acc/Gcc	-0.17	0	0.83	benign	0	neutral	0.83	neutral	2.08	neutral	0.42	neutral	-1.39	neutral_impact	-0.24	0.95	neutral	0.89	neutral	-0.99	0.02	neutral	0.36	0.5	0.09	neutral	0.01	neutral	0.28	neutral	0.17	neutral	7	0.17	neutral	0.92	deleterious	-6	neutral	0.04	neutral	1.99	medium_impact	0.57	medium_impact	-1.33	low_impact	0.37	0.8	NA	NA	0.44	N	0.00	polymorphism	1	0.18	rs2853826	protective	Parkinson_disease,_resistance_to	24752	MedGen:C4016597	thyroid tumor	.	.	.	A10398G	PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / ADHD / cognitive decline	+	-	Reported, haplogroup IJK marker	29	N	P	N,P	neutral
chrM	10398	10398	A	T	MI.15682	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	340	114	T	S	Acc/Tcc	-0.17	0	0.83	benign	0.02	neutral	0.77	neutral	2	neutral	0.06	neutral	-1.4	low_impact	0.97	0.84	neutral	0.81	neutral	0.51	7.47	deleterious	0.5	0.6	0.13	neutral	0.07	neutral	0.31	neutral	0.29	neutral	4	0.19	neutral	0.88	deleterious	-6	neutral	0.09	neutral	0.81	medium_impact	0.48	medium_impact	-0.22	medium_impact	0.52	0.8	NA	NA	0.33	N	0.36	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10398	10398	A	C	MI.15683	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	340	114	T	P	Acc/Ccc	-0.17	0	0.83	benign	0.08	neutral	0.3	neutral	1.91	neutral	-1.94	deleterious	-3.18	medium_impact	2.13	0.62	neutral	0.31	neutral	1.82	15.11	deleterious	0.2	0.45	0.44	neutral	0.38	neutral	0.5	neutral	0.44	neutral	1	0.66	neutral	0.61	deleterious	-3	neutral	0.20	neutral	0.24	medium_impact	-0.01	medium_impact	0.84	medium_impact	0.37	0.8	NA	NA	0.41	N	0.68	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10399	10399	C	G	MI.15684	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	341	114	T	S	aCc/aGc	-0.17	0	0	benign	0.02	neutral	0.77	neutral	2	neutral	0.06	neutral	-1.4	low_impact	0.97	0.84	neutral	0.81	neutral	0.57	7.97	deleterious	0.5	0.6	0.13	neutral	0.07	neutral	0.31	neutral	0.29	neutral	4	0.19	neutral	0.88	deleterious	-6	neutral	0.09	neutral	0.81	medium_impact	0.48	medium_impact	-0.22	medium_impact	0.52	0.8	NA	NA	0.34	N	0.36	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10399	10399	C	A	MI.15685	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	341	114	T	N	aCc/aAc	-0.17	0	0	benign	0	neutral	0.55	neutral	1.94	neutral	-0.77	neutral	-2.47	low_impact	0.98	0.8	neutral	0.78	neutral	0.89	10.05	neutral	0.49	0.55	0.38	neutral	0.28	neutral	0.45	neutral	0.42	neutral	2	0.45	neutral	0.78	deleterious	-6	neutral	0.12	neutral	1.99	medium_impact	0.24	medium_impact	-0.21	medium_impact	0.43	0.8	NA	NA	0.3	N	0.59	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10399	10399	C	T	MI.15686	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	341	114	T	I	aCc/aTc	-0.17	0	0	benign	0	neutral	0.29	neutral	1.98	neutral	0.05	deleterious	-3.08	low_impact	1.17	0.82	neutral	0.8	neutral	2.01	16.29	deleterious	0.28	0.45	0.43	neutral	0.16	neutral	0.46	neutral	0.34	neutral	3	0.71	neutral	0.65	deleterious	-6	neutral	0.14	neutral	1.99	medium_impact	-0.03	medium_impact	-0.04	medium_impact	0.36	0.8	NA	NA	0.38	N	0.54	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10401	10401	G	C	MI.15687	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	343	115	E	Q	Gaa/Caa	-7.09	0	0	probably_damaging	1	neutral	0.58	neutral	1.66	neutral	-1.29	deleterious	-2.54	medium_impact	2.44	0.57	damaging	0.17	damaging	3.47	23.00	deleterious	0.29	0.45	0.55	disease	0.19	neutral	0.45	neutral	0.38	neutral	2	1	deleterious	0.29	neutral	1	deleterious	0.91	deleterious	-3.43	low_impact	0.27	medium_impact	1.13	medium_impact	0.60	0.8	NA	NA	0.28	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10401	10401	G	A	MI.15688	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	343	115	E	K	Gaa/Aaa	-7.09	0	0	probably_damaging	1	neutral	0.92	neutral	1.69	neutral	-0.72	deleterious	-3.31	low_impact	1.61	0.55	damaging	0.66	neutral	4.52	24.30	deleterious	0.24	0.45	0.49	neutral	0.26	neutral	0.35	neutral	0.36	neutral	3	0.99	deleterious	0.46	neutral	-2	neutral	0.92	deleterious	-3.43	low_impact	0.78	medium_impact	0.37	medium_impact	0.46	0.8	NA	NA	0.31	N	0.99	polymorphism	1	0.07	rs28719882	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10402	10402	A	T	MI.15689	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	344	115	E	V	gAa/gTa	1.44	0.98	0	probably_damaging	1	neutral	0.29	neutral	1.62	neutral	-1.58	deleterious	-6.2	medium_impact	2.87	0.5	damaging	0.09	damaging	4.37	24.10	deleterious	0.12	0.4	0.69	disease	0.31	neutral	0.51	disease	0.57	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.92	deleterious	-3.43	low_impact	-0.03	medium_impact	1.52	medium_impact	0.41	0.8	NA	NA	0.54	P	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8426	8426	T	A	MI.1569	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	61	21	F	I	Ttc/Atc	-2.19	0	0	probably_damaging	0.97	neutral	0.5	neutral	1.86	deleterious	-5.37	deleterious	-5.5	medium_impact	2.62	1	neutral	0.47	neutral	4.23	23.90	deleterious	0.25340804	0.85	0.72	disease	0.42	neutral	0.65	disease	0.28	neutral	5	0.97	neutral	0.27	neutral	1	deleterious	0.78	deleterious	-2.19	low_impact	0.29	medium_impact	1.15	medium_impact	0.51	0.85	NA	NA	0.48	N	0.80	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10402	10402	A	G	MI.15690	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	344	115	E	G	gAa/gGa	1.44	0.98	0	probably_damaging	1	neutral	0.38	neutral	1.64	neutral	-1.72	deleterious	-6.19	medium_impact	3.07	0.5	damaging	0.15	damaging	4.39	24.10	deleterious	0.2	0.45	0.56	disease	0.2	neutral	0.51	disease	0.41	neutral	2	1	deleterious	0.19	neutral	1	deleterious	0.91	deleterious	-3.43	low_impact	0.07	medium_impact	1.71	medium_impact	0.35	0.8	NA	NA	0.58	P	0.60	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10402	10402	A	C	MI.15691	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	344	115	E	A	gAa/gCa	1.44	0.98	0	probably_damaging	1	neutral	0.76	neutral	1.67	neutral	-1.02	deleterious	-5.29	medium_impact	3.42	0.57	damaging	0.13	damaging	3.79	23.40	deleterious	0.23	0.45	0.53	disease	0.23	neutral	0.48	neutral	0.33	neutral	3	0.99	deleterious	0.38	neutral	1	deleterious	0.91	deleterious	-3.43	low_impact	0.47	medium_impact	2.03	high_impact	0.35	0.8	NA	NA	0.48	N	0.74	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10403	10403	A	C	MI.15692	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	345	115	E	D	gaA/gaC	5.6	1	0	probably_damaging	0.99	neutral	0.62	neutral	1.72	neutral	-0.78	deleterious	-2.65	medium_impact	2.52	0.62	neutral	0.13	damaging	3.76	23.30	deleterious	0.36	0.5	0.38	neutral	0.16	neutral	0.3	neutral	0.26	neutral	5	0.99	deleterious	0.32	neutral	1	deleterious	0.90	deleterious	-2.52	low_impact	0.31	medium_impact	1.2	medium_impact	0.51	0.8	NA	NA	0.56	P	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10403	10403	A	T	MI.15693	MT-ND3	I	ENSG00000198840	ENSP00000355206	ENST00000361227	NU3M_HUMAN	P03897	4537	YP_003024033.1	345	115	E	D	gaA/gaT	5.6	1	0	probably_damaging	0.99	neutral	0.62	neutral	1.72	neutral	-0.78	deleterious	-2.65	medium_impact	2.52	0.62	neutral	0.13	damaging	3.89	23.50	deleterious	0.36	0.5	0.38	neutral	0.16	neutral	0.3	neutral	0.26	neutral	5	0.99	deleterious	0.32	neutral	1	deleterious	0.90	deleterious	-2.52	low_impact	0.31	medium_impact	1.2	medium_impact	0.51	0.8	NA	NA	0.57	P	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10470	10470	A	C	MI.15694	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	1	1	M	L	Atg/Ctg	0.29	0.02	0	probably_damaging	0.97	deleterious	0	neutral	2.06	neutral	0.92	deleterious	-2.89	NA	NA	0.55	damaging	0.13	damaging	2.91	21.90	deleterious	0.52	0.6	0.44	neutral	0.42	neutral	0.56	disease	0.43	neutral	1	1	deleterious	0.02	neutral	4	deleterious	0.73	deleterious	NA	NA	NA	NA	NA	NA	0.55	0.8	53.06	11.94	0.36	N	0.88	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10471	10471	T	A	MI.15695	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	2	1	M	K	aTg/aAg	4.67	1	0	probably_damaging	0.99	deleterious	0	neutral	1.85	neutral	-1.35	deleterious	-5.57	NA	NA	0.57	damaging	0.13	damaging	3.86	23.50	deleterious	0.31	0.45	0.62	disease	0.63	disease	0.67	disease	0.68	disease	4	1	deleterious	0.01	neutral	4	deleterious	0.84	deleterious	NA	NA	NA	NA	NA	NA	0.38	0.8	53.06	11.94	0.52	P	0.93	NA	NA	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10473	10473	C	A	MI.15696	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	4	2	P	T	Ccc/Acc	3.52	1	0	benign	0.03	neutral	0.69	neutral	2.02	neutral	0.36	neutral	-1.61	neutral_impact	0.04	0.9	neutral	0.99	neutral	-1.27	0.01	neutral	0.55	0.6	0.12	neutral	0.05	neutral	0.12	neutral	0.23	neutral	5	0.26	neutral	0.83	deleterious	-6	neutral	0.07	neutral	0.58	medium_impact	0.4	medium_impact	-1.1	low_impact	0.61	0.8	29.59	16.37	0.51	N	0.03	polymorphism	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10473	10473	C	T	MI.15697	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	4	2	P	S	Ccc/Tcc	3.52	1	0	benign	0.04	neutral	0.75	neutral	2.05	neutral	0.54	neutral	-1.52	neutral_impact	0.16	0.93	neutral	1	neutral	-0.76	0.05	neutral	0.6	0.65	0.11	neutral	0.05	neutral	0.12	neutral	0.24	neutral	5	0.18	neutral	0.86	deleterious	-6	neutral	0.07	neutral	0.46	medium_impact	0.48	medium_impact	-1	low_impact	0.37	0.8	29.59	16.37	0.5	N	0.06	polymorphism	0.9	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10473	10473	C	G	MI.15698	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	4	2	P	A	Ccc/Gcc	3.52	1	0	benign	0.21	neutral	0.52	neutral	2.04	neutral	0.64	deleterious	-2.57	neutral_impact	0.26	0.9	neutral	0.87	neutral	-0.24	0.90	neutral	0.58	0.65	0.16	neutral	0.09	neutral	0.29	neutral	0.25	neutral	5	0.37	neutral	0.66	deleterious	-6	neutral	0.14	neutral	-0.28	medium_impact	0.23	medium_impact	-0.92	medium_impact	0.62	0.8	29.59	16.37	0.5	N	0.28	polymorphism	0.94	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10474	10474	C	G	MI.15699	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	5	2	P	R	cCc/cGc	-2.48	0	0	possibly_damaging	0.71	neutral	0.28	neutral	2	neutral	-0.7	deleterious	-3.73	low_impact	1.9	0.8	neutral	0.51	neutral	1.63	13.99	neutral	0.44	0.55	0.2	neutral	0.39	neutral	0.41	neutral	0.44	neutral	1	0.79	neutral	0.29	neutral	-3	neutral	0.45	deleterious	-1.16	low_impact	-0.02	medium_impact	0.46	medium_impact	0.42	0.8	29.59	16.37	0.37	N	0.59	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8599	8599	C	A	MI.157	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	73	25	L	M	Cta/Ata	-4.27	0	0	probably_damaging	1	neutral	0.26	neutral	4.16	neutral	-2.65	neutral	-0.02	neutral_impact	0.4	0.87	neutral	0.84	neutral	1.37	12.65	neutral	0.36	0.65	0.63	disease	0.08	neutral	0.32	neutral	0.37	neutral	3	1	deleterious	0.13	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.04	medium_impact	-0.76	medium_impact	0.50	0.9	10.18	13.06	0.52	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8426	8426	T	C	MI.1570	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	61	21	F	L	Ttc/Ctc	-2.19	0	0	probably_damaging	0.96	neutral	1	neutral	2.28	deleterious	-4.27	deleterious	-5.44	low_impact	1.92	0.99	neutral	0.62	neutral	3.82	23.40	deleterious	0.39211194	0.85	0.55	disease	0.4	neutral	0.58	disease	0.24	neutral	5	0.96	neutral	0.52	deleterious	-2	neutral	0.74	deleterious	-2.07	low_impact	1.98	high_impact	0.55	medium_impact	0.43	0.85	NA	NA	0.36	N	0.75	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10474	10474	C	A	MI.15700	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	5	2	P	H	cCc/cAc	-2.48	0	0	possibly_damaging	0.87	neutral	0.43	neutral	1.95	neutral	-1.9	deleterious	-3.94	low_impact	1.36	0.89	neutral	0.67	neutral	3.45	23.00	deleterious	0.59	0.65	0.33	neutral	0.2	neutral	0.22	neutral	0.38	neutral	3	0.87	neutral	0.28	neutral	-3	neutral	0.57	deleterious	-1.56	low_impact	0.14	medium_impact	0	medium_impact	0.41	0.8	29.59	16.37	0.41	N	0.57	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10474	10474	C	T	MI.15701	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	5	2	P	L	cCc/cTc	-2.48	0	0	benign	0.03	neutral	1	neutral	2	neutral	-0.61	deleterious	-4.44	neutral_impact	0.58	0.81	neutral	0.51	neutral	1.14	11.45	neutral	0.54	0.6	0.21	neutral	0.25	neutral	0.3	neutral	0.43	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.11	neutral	0.58	medium_impact	1.88	high_impact	-0.65	medium_impact	0.74	0.85	29.59	16.37	0.23	N	0.63	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10476	10476	C	T	MI.15702	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	7	3	L	F	Ctc/Ttc	-11.7	0	0	benign	0.01	neutral	0.76	neutral	1.81	neutral	-2.02	neutral	-1	neutral_impact	0	0.9	neutral	0.94	neutral	-0.45	0.29	neutral	0.55	0.6	0.24	neutral	0.19	neutral	0.28	neutral	0.34	neutral	3	0.21	neutral	0.88	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.49	medium_impact	-1.14	low_impact	0.71	0.85	31.63	22.49	0.43	N	0.29	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10476	10476	C	G	MI.15703	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	7	3	L	V	Ctc/Gtc	-11.7	0	0	benign	0.01	neutral	0.52	neutral	1.9	neutral	-0.68	neutral	-0.24	neutral_impact	0	0.91	neutral	0.88	neutral	-0.59	0.13	neutral	0.61	0.65	0.25	neutral	0.21	neutral	0.38	neutral	0.36	neutral	3	0.46	neutral	0.76	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.23	medium_impact	-1.14	low_impact	0.60	0.8	31.63	22.49	0.38	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10476	10476	C	A	MI.15704	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	7	3	L	I	Ctc/Atc	-11.7	0	0	benign	0.01	neutral	0.56	neutral	1.88	neutral	-1.02	neutral	-0.1	neutral_impact	0	0.97	neutral	0.97	neutral	0.19	4.55	deleterious	0.54	0.6	0.28	neutral	0.19	neutral	0.28	neutral	0.35	neutral	3	0.43	neutral	0.78	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.27	medium_impact	-1.14	low_impact	0.70	0.85	31.63	22.49	0.37	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10477	10477	T	C	MI.15705	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	8	3	L	P	cTc/cCc	-5.47	0	0	benign	0.01	neutral	0.4	neutral	1.77	neutral	-2.61	neutral	-0.66	neutral_impact	0	0.9	neutral	0.96	neutral	0.20	4.65	deleterious	0.52	0.6	0.31	neutral	0.11	neutral	0.44	neutral	0.3	neutral	4	0.59	neutral	0.7	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.11	medium_impact	-1.14	low_impact	0.55	0.8	31.63	22.49	0.45	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10477	10477	T	A	MI.15706	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	8	3	L	H	cTc/cAc	-5.47	0	0	possibly_damaging	0.66	neutral	0.48	neutral	1.77	neutral	-2.46	neutral	-2.06	neutral_impact	0	0.81	neutral	0.75	neutral	1.88	15.46	deleterious	0.38	0.5	0.61	disease	0.37	neutral	0.35	neutral	0.61	disease	2	0.64	neutral	0.41	neutral	-3	neutral	0.68	deleterious	-1.07	low_impact	0.19	medium_impact	-1.14	low_impact	0.63	0.8	31.63	22.49	0.27	N	0.47	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10477	10477	T	G	MI.15707	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	8	3	L	R	cTc/cGc	-5.47	0	0	possibly_damaging	0.55	neutral	0.33	neutral	1.79	neutral	-1.26	neutral	-2.03	neutral_impact	0	0.71	neutral	0.47	neutral	2.07	16.69	deleterious	0.4	0.5	0.52	disease	0.67	disease	0.49	neutral	0.55	disease	1	0.66	neutral	0.39	neutral	-3	neutral	0.59	deleterious	-0.88	medium_impact	0.04	medium_impact	-1.14	low_impact	0.63	0.8	31.63	22.49	0.27	N	0.39	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10479	10479	A	C	MI.15708	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	10	4	I	L	Att/Ctt	-7.78	0	0	benign	0.26	neutral	1	neutral	2.14	neutral	0.78	neutral	-1.44	low_impact	1.01	0.88	neutral	0.81	neutral	0.24	5.14	deleterious	0.48	0.55	0.12	neutral	0.2	neutral	0.37	neutral	0.34	neutral	3	0.26	neutral	0.87	deleterious	-6	neutral	0.13	neutral	-0.39	medium_impact	1.88	high_impact	-0.29	medium_impact	0.52	0.8	27.55	22.37	0.29	N	0.31	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10479	10479	A	G	MI.15709	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	10	4	I	V	Att/Gtt	-7.78	0	0	benign	0.05	neutral	0.58	neutral	1.93	neutral	-0.56	neutral	-0.29	neutral_impact	0.36	0.96	neutral	1	neutral	-0.98	0.02	neutral	0.75	0.8	0.12	neutral	0.06	neutral	0.39	neutral	0.24	neutral	5	0.36	neutral	0.77	deleterious	-6	neutral	0.09	neutral	0.37	medium_impact	0.29	medium_impact	-0.84	medium_impact	0.22	0.8	27.55	22.37	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8426	8426	T	G	MI.1571	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	61	21	F	V	Ttc/Gtc	-2.19	0	0	probably_damaging	0.97	neutral	0.13	neutral	1.81	deleterious	-5.39	deleterious	-6.36	medium_impact	3.32	1	neutral	0.5	neutral	3.88	23.50	deleterious	0.25207871	0.85	0.72	disease	0.47	neutral	0.69	disease	0.34	neutral	3	0.99	deleterious	0.08	neutral	1	deleterious	0.80	deleterious	-2.19	low_impact	-0.18	medium_impact	1.75	medium_impact	0.50	0.85	NA	NA	0.54	N	0.83	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10479	10479	A	T	MI.15710	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	10	4	I	F	Att/Ttt	-7.78	0	0	probably_damaging	0.91	neutral	1	neutral	1.88	neutral	-1.22	deleterious	-3.19	low_impact	1.19	0.78	neutral	0.42	neutral	3.52	23.10	deleterious	0.54	0.6	0.35	neutral	0.41	neutral	0.54	disease	0.46	neutral	1	0.91	neutral	0.55	deleterious	-2	neutral	0.57	deleterious	-1.72	low_impact	1.88	high_impact	-0.14	medium_impact	0.53	0.8	27.55	22.37	0.2	N	0.45	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10480	10480	T	C	MI.15711	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	11	4	I	T	aTt/aCt	-0.63	0	0	benign	0.11	neutral	0.6	neutral	1.88	neutral	-1.26	deleterious	-2.63	neutral_impact	-0.26	0.91	neutral	0.98	neutral	-0.39	0.41	neutral	0.71	0.75	0.18	neutral	0.19	neutral	0.4	neutral	0.34	neutral	3	0.3	neutral	0.75	deleterious	-6	neutral	0.12	neutral	0.03	medium_impact	0.31	medium_impact	-1.36	low_impact	0.37	0.8	27.55	22.37	0.36	N	0.05	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10480	10480	T	G	MI.15712	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	11	4	I	S	aTt/aGt	-0.63	0	0	possibly_damaging	0.76	neutral	0.61	neutral	1.86	neutral	-1.59	deleterious	-4.12	medium_impact	2.16	0.83	neutral	0.68	neutral	2.62	20.30	deleterious	0.55	0.6	0.35	neutral	0.46	neutral	0.51	disease	0.47	neutral	1	0.72	neutral	0.43	neutral	0	NA	0.41	neutral	-1.26	low_impact	0.32	medium_impact	0.67	medium_impact	0.44	0.8	27.55	22.37	0.28	N	0.40	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10480	10480	T	A	MI.15713	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	11	4	I	N	aTt/aAt	-0.63	0	0	probably_damaging	0.91	neutral	0.27	neutral	1.8	deleterious	-3.79	deleterious	-5.05	medium_impact	2.16	0.84	neutral	0.46	neutral	4.15	23.80	deleterious	0.52	0.6	0.52	disease	0.53	disease	0.47	neutral	0.52	disease	0	0.93	neutral	0.18	neutral	1	deleterious	0.63	deleterious	-1.72	low_impact	-0.03	medium_impact	0.67	medium_impact	0.57	0.8	27.55	22.37	0.36	N	0.60	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10481	10481	T	A	MI.15714	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	12	4	I	M	atT/atA	0.52	0	0	benign	0.4	neutral	0.52	neutral	1.87	neutral	-1.4	neutral	-1.88	low_impact	1.01	0.91	neutral	0.94	neutral	2.01	16.31	deleterious	0.65	0.7	0.35	neutral	0.18	neutral	0.37	neutral	0.29	neutral	4	0.42	neutral	0.56	deleterious	-6	neutral	0.24	neutral	-0.64	medium_impact	0.23	medium_impact	-0.29	medium_impact	0.56	0.8	27.55	22.37	0.43	N	0.50	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10481	10481	T	G	MI.15715	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	12	4	I	M	atT/atG	0.52	0	0	benign	0.4	neutral	0.52	neutral	1.87	neutral	-1.4	neutral	-1.88	low_impact	1.01	0.91	neutral	0.94	neutral	1.78	14.85	neutral	0.65	0.7	0.35	neutral	0.18	neutral	0.37	neutral	0.29	neutral	4	0.42	neutral	0.56	deleterious	-6	neutral	0.24	neutral	-0.64	medium_impact	0.23	medium_impact	-0.29	medium_impact	0.56	0.8	27.55	22.37	0.44	N	0.50	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10482	10482	T	G	MI.15716	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	13	5	Y	D	Tac/Gac	-9.16	0	0	probably_damaging	0.96	neutral	0.2	neutral	1.93	neutral	-2.8	deleterious	-5.27	low_impact	1.87	0.66	neutral	0.4	neutral	3.73	23.30	deleterious	0.47	0.55	0.81	disease	0.7	disease	0.64	disease	0.75	disease	5	0.97	neutral	0.12	neutral	-2	neutral	0.78	deleterious	-2.07	low_impact	-0.12	medium_impact	0.43	medium_impact	0.49	0.8	34.69	11.85	0.27	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10482	10482	T	A	MI.15717	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	13	5	Y	N	Tac/Aac	-9.16	0	0	probably_damaging	0.92	neutral	0.31	neutral	1.93	neutral	-2.04	deleterious	-4.27	neutral_impact	0.12	0.84	neutral	0.87	neutral	2.46	19.20	deleterious	0.54	0.6	0.72	disease	0.49	neutral	0.53	disease	0.58	disease	2	0.93	neutral	0.2	neutral	-2	neutral	0.72	deleterious	-1.78	low_impact	0.02	medium_impact	-1.04	low_impact	0.37	0.8	34.69	11.85	0.32	N	0.55	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10482	10482	T	C	MI.15718	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	13	5	Y	H	Tac/Cac	-9.16	0	0	benign	0.25	neutral	0.54	neutral	1.96	neutral	-1.56	deleterious	-2.6	neutral_impact	0.17	0.84	neutral	0.97	neutral	-1.18	0.01	neutral	0.63	0.7	0.17	neutral	0.1	neutral	0.45	neutral	0.25	neutral	5	0.35	neutral	0.65	deleterious	-6	neutral	0.15	neutral	-0.37	medium_impact	0.25	medium_impact	-1	medium_impact	0.43	0.8	34.69	11.85	0.31	N	0.35	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10483	10483	A	T	MI.15719	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	14	5	Y	F	tAc/tTc	-0.4	0	0	benign	0.17	neutral	0.7	neutral	1.96	neutral	0.12	neutral	-1.39	low_impact	0.83	0.92	neutral	0.97	neutral	0.11	3.74	deleterious	0.53	0.6	0.19	neutral	0.37	neutral	0.46	neutral	0.44	neutral	1	0.18	neutral	0.77	deleterious	-6	neutral	0.17	neutral	-0.17	medium_impact	0.41	medium_impact	-0.44	medium_impact	0.47	0.8	34.69	11.85	0.33	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8427	8427	T	C	MI.1572	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	62	21	F	S	tTc/tCc	0.82	0	0	probably_damaging	0.98	neutral	0.3	neutral	1.77	deleterious	-6.46	deleterious	-7.42	low_impact	1.82	1	neutral	0.41	neutral	4.16	23.80	deleterious	0.27134083	0.85	0.82	disease	0.45	neutral	0.67	disease	0.31	neutral	4	0.99	deleterious	0.16	neutral	-2	neutral	0.77	deleterious	-2.36	low_impact	0.08	medium_impact	0.46	medium_impact	0.39	0.85	NA	NA	0.51	N	0.86	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10483	10483	A	G	MI.15720	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	14	5	Y	C	tAc/tGc	-0.4	0	0	probably_damaging	0.98	neutral	0.18	neutral	1.91	deleterious	-3.68	deleterious	-4.54	low_impact	1.87	0.64	neutral	0.51	neutral	3.38	22.90	deleterious	0.53	0.6	0.85	disease	0.61	disease	0.64	disease	0.73	disease	5	0.99	deleterious	0.1	neutral	-2	neutral	0.76	deleterious	-2.35	low_impact	-0.16	medium_impact	0.43	medium_impact	0.20	0.8	34.69	11.85	0.32	N	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10483	10483	A	C	MI.15721	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	14	5	Y	S	tAc/tCc	-0.4	0	0	probably_damaging	0.94	neutral	0.4	neutral	2.02	neutral	-1.68	deleterious	-3.88	neutral_impact	0.63	0.86	neutral	0.85	neutral	2.32	18.28	deleterious	0.47	0.55	0.67	disease	0.43	neutral	0.57	disease	0.64	disease	3	0.94	neutral	0.23	neutral	-2	neutral	0.70	deleterious	-1.9	low_impact	0.11	medium_impact	-0.61	medium_impact	0.37	0.8	34.69	11.85	0.32	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10485	10485	A	T	MI.15722	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	16	6	M	L	Ata/Tta	-7.32	0	0	benign	0.01	neutral	1	neutral	2.3	neutral	2.74	neutral	-0.17	neutral_impact	-0.9	0.85	neutral	0.99	neutral	-1.45	0.00	neutral	0.75	0.8	0.15	neutral	0.22	neutral	0.49	neutral	0.39	neutral	2	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	1.88	high_impact	-1.89	low_impact	0.71	0.85	23.47	19.01	0.33	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10485	10485	A	G	MI.15723	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	16	6	M	V	Ata/Gta	-7.32	0	0	benign	0.01	neutral	0.33	neutral	2.1	neutral	1.51	neutral	-0.66	neutral_impact	0.38	0.92	neutral	0.97	neutral	-0.46	0.27	neutral	0.66	0.7	0.15	neutral	0.4	neutral	0.55	disease	0.47	neutral	1	0.66	neutral	0.66	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.04	medium_impact	-0.82	medium_impact	0.69	0.85	23.47	19.01	0.31	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10485	10485	A	C	MI.15724	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	16	6	M	L	Ata/Cta	-7.32	0	0	benign	0.01	neutral	1	neutral	2.3	neutral	2.74	neutral	-0.17	neutral_impact	-0.9	0.85	neutral	0.99	neutral	-1.49	0.00	neutral	0.75	0.8	0.15	neutral	0.22	neutral	0.49	neutral	0.39	neutral	2	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	1.88	high_impact	-1.89	low_impact	0.71	0.85	23.47	19.01	0.33	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10486	10486	T	C	MI.15725	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	17	6	M	T	aTa/aCa	-2.24	0	0	benign	0.01	neutral	0.15	neutral	2.04	neutral	0.8	neutral	-2.49	neutral_impact	-0.4	0.88	neutral	0.96	neutral	-0.28	0.75	neutral	0.58	0.65	0.24	neutral	0.32	neutral	0.55	disease	0.47	neutral	1	0.85	neutral	0.57	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	-0.21	medium_impact	-1.47	low_impact	0.49	0.8	23.47	19.01	0.37	N	0.57	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10486	10486	T	A	MI.15726	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	17	6	M	K	aTa/aAa	-2.24	0	0	benign	0.26	deleterious	0.04	neutral	1.97	neutral	-1.23	deleterious	-3.96	low_impact	1.39	0.71	neutral	0.53	neutral	2.21	17.59	deleterious	0.37	0.5	0.4	neutral	0.65	disease	0.74	disease	0.76	disease	5	0.95	neutral	0.39	neutral	-2	neutral	0.34	neutral	-0.39	medium_impact	-0.56	medium_impact	0.03	medium_impact	0.73	0.85	23.47	19.01	0.37	N	0.84	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10487	10487	A	T	MI.15727	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	18	6	M	I	atA/atT	0.98	0	0	benign	0.01	neutral	0.67	neutral	2.12	neutral	1.67	neutral	-0.21	neutral_impact	-0.32	0.91	neutral	0.98	neutral	-0.47	0.26	neutral	0.65	0.7	0.12	neutral	0.31	neutral	0.51	disease	0.44	neutral	1	0.32	neutral	0.83	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.38	medium_impact	-1.41	low_impact	0.71	0.85	23.47	19.01	0.36	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10487	10487	A	C	MI.15728	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	18	6	M	I	atA/atC	0.98	0	0	benign	0.01	neutral	0.67	neutral	2.12	neutral	1.67	neutral	-0.21	neutral_impact	-0.32	0.91	neutral	0.98	neutral	-0.55	0.17	neutral	0.65	0.7	0.12	neutral	0.31	neutral	0.51	disease	0.44	neutral	1	0.32	neutral	0.83	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.38	medium_impact	-1.41	low_impact	0.71	0.85	23.47	19.01	0.36	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10488	10488	A	G	MI.15729	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	19	7	N	D	Aat/Gat	-3.17	0	0	possibly_damaging	0.83	neutral	0.2	neutral	1.93	neutral	-2.97	deleterious	-4.77	medium_impact	3.23	0.76	neutral	0.52	neutral	3.66	23.20	deleterious	0.73	0.75	0.36	neutral	0.69	disease	0.58	disease	0.71	disease	4	0.9	neutral	0.19	neutral	0	NA	0.63	deleterious	-1.43	low_impact	-0.12	medium_impact	1.57	medium_impact	0.70	0.85	54.08	12.33	0.47	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8427	8427	T	A	MI.1573	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	62	21	F	Y	tTc/tAc	0.82	0	0	probably_damaging	0.96	neutral	0.16	neutral	1.77	deleterious	-4.27	neutral	-2	medium_impact	2.31	0.99	neutral	0.65	neutral	2.56	19.86	deleterious	0.22453471	0.85	0.5	neutral	0.11	neutral	0.58	disease	0.05	neutral	9	0.98	neutral	0.1	neutral	1	deleterious	0.70	deleterious	-2.07	low_impact	-0.12	medium_impact	0.88	medium_impact	0.64	0.85	NA	NA	0.59	P	0.35	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10488	10488	A	C	MI.15730	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	19	7	N	H	Aat/Cat	-3.17	0	0	probably_damaging	0.98	neutral	0.54	neutral	1.94	neutral	-2.47	deleterious	-4.62	medium_impact	2.89	0.83	neutral	0.5	neutral	3.03	22.30	deleterious	0.57	0.65	0.53	disease	0.68	disease	0.53	disease	0.63	disease	3	0.97	neutral	0.28	neutral	1	deleterious	0.71	deleterious	-2.35	low_impact	0.25	medium_impact	1.28	medium_impact	0.75	0.85	54.08	12.33	0.22	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10488	10488	A	T	MI.15731	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	19	7	N	Y	Aat/Tat	-3.17	0	0	probably_damaging	0.98	neutral	1	neutral	1.95	neutral	-1.29	deleterious	-7.29	medium_impact	2.68	0.84	neutral	0.51	neutral	3.65	23.20	deleterious	0.54	0.6	0.56	disease	0.76	disease	0.54	disease	0.7	disease	4	0.98	deleterious	0.51	deleterious	1	deleterious	0.74	deleterious	-2.35	low_impact	1.88	high_impact	1.11	medium_impact	0.62	0.8	54.08	12.33	0.19	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10489	10489	A	T	MI.15732	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	20	7	N	I	aAt/aTt	3.06	0.34	0	probably_damaging	0.92	neutral	0.4	neutral	2.08	neutral	1.06	deleterious	-8.45	medium_impact	2.08	0.8	neutral	0.65	neutral	3.63	23.20	deleterious	0.49	0.55	0.43	neutral	0.82	disease	0.46	neutral	0.6	disease	2	0.92	neutral	0.24	neutral	1	deleterious	0.72	deleterious	-1.78	low_impact	0.11	medium_impact	0.61	medium_impact	0.55	0.8	54.08	12.33	0.32	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10489	10489	A	G	MI.15733	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	20	7	N	S	aAt/aGt	3.06	0.34	0	benign	0.26	neutral	0.42	neutral	2.02	neutral	0.36	deleterious	-4.71	low_impact	1.44	0.83	neutral	0.73	neutral	-0.92	0.02	neutral	0.85	0.85	0.12	neutral	0.2	neutral	0.46	neutral	0.34	neutral	3	0.49	neutral	0.58	deleterious	-6	neutral	0.22	neutral	-0.39	medium_impact	0.13	medium_impact	0.07	medium_impact	0.56	0.8	54.08	12.33	0.37	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10489	10489	A	C	MI.15734	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	20	7	N	T	aAt/aCt	3.06	0.34	0	benign	0.26	neutral	0.4	neutral	2.19	neutral	1.9	deleterious	-5.58	low_impact	1.62	0.77	neutral	0.69	neutral	0.22	4.89	deleterious	0.66	0.7	0.32	neutral	0.39	neutral	0.45	neutral	0.45	neutral	1	0.52	neutral	0.57	deleterious	-6	neutral	0.59	deleterious	-0.39	medium_impact	0.11	medium_impact	0.22	medium_impact	0.80	0.85	54.08	12.33	0.37	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10490	10490	T	G	MI.15735	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	21	7	N	K	aaT/aaG	1.44	0.31	0	possibly_damaging	0.83	neutral	0.29	neutral	1.94	neutral	-1.81	deleterious	-5.69	medium_impact	3.23	0.79	neutral	0.48	neutral	3.67	23.20	deleterious	0.79	0.8	0.29	neutral	0.78	disease	0.59	disease	0.74	disease	5	0.87	neutral	0.23	neutral	0	NA	0.66	deleterious	-1.43	low_impact	-0.01	medium_impact	1.57	medium_impact	0.81	0.85	54.08	12.33	0.39	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10490	10490	T	A	MI.15736	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	21	7	N	K	aaT/aaA	1.44	0.31	0	possibly_damaging	0.83	neutral	0.29	neutral	1.94	neutral	-1.81	deleterious	-5.69	medium_impact	3.23	0.79	neutral	0.48	neutral	3.99	23.60	deleterious	0.79	0.8	0.29	neutral	0.78	disease	0.59	disease	0.74	disease	5	0.87	neutral	0.23	neutral	0	NA	0.66	deleterious	-1.43	low_impact	-0.01	medium_impact	1.57	medium_impact	0.81	0.85	54.08	12.33	0.41	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10491	10491	A	T	MI.15737	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	22	8	I	F	Att/Ttt	-8.93	0	0	possibly_damaging	0.87	neutral	0.94	neutral	1.79	neutral	-1.61	deleterious	-3.01	low_impact	1.74	0.72	neutral	0.83	neutral	0.56	7.84	deleterious	0.63	0.7	0.15	neutral	0.18	neutral	0.35	neutral	0.22	neutral	6	0.86	neutral	0.54	deleterious	-3	neutral	0.60	deleterious	-1.56	low_impact	0.87	medium_impact	0.32	medium_impact	0.81	0.85	27.55	11.42	0.34	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10491	10491	A	G	MI.15738	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	22	8	I	V	Att/Gtt	-8.93	0	0	benign	0.05	neutral	0.4	neutral	1.86	neutral	-0.94	neutral	-0.6	low_impact	1.45	0.84	neutral	0.94	neutral	-0.63	0.11	neutral	0.69	0.75	0.21	neutral	0.27	neutral	0.48	neutral	0.44	neutral	1	0.56	neutral	0.68	deleterious	-6	neutral	0.13	neutral	0.37	medium_impact	0.11	medium_impact	0.08	medium_impact	0.77	0.85	27.55	11.42	0.37	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10491	10491	A	C	MI.15739	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	22	8	I	L	Att/Ctt	-8.93	0	0	benign	0.05	neutral	1	neutral	1.85	neutral	-1	neutral	-0.8	neutral_impact	0.22	0.77	neutral	0.95	neutral	-0.08	1.87	neutral	0.37	0.5	0.11	neutral	0.33	neutral	0.33	neutral	0.44	neutral	1	0.05	neutral	0.98	deleterious	-6	neutral	0.35	neutral	0.37	medium_impact	1.88	high_impact	-0.95	medium_impact	0.75	0.85	27.55	11.42	0.28	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8427	8427	T	G	MI.1574	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	62	21	F	C	tTc/tGc	0.82	0	0	probably_damaging	1	deleterious	0.04	neutral	1.73	deleterious	-7.99	deleterious	-7.39	medium_impact	3.12	0.99	neutral	0.38	neutral	3.96	23.60	deleterious	0.21080113	0.85	0.92	disease	0.46	neutral	0.71	disease	0.37	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-0.49	medium_impact	1.58	medium_impact	0.32	0.85	NA	NA	0.53	N	0.92	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10492	10492	T	A	MI.15740	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	23	8	I	N	aTt/aAt	-0.86	0	0	possibly_damaging	0.87	neutral	0.15	neutral	1.71	deleterious	-3.97	deleterious	-5.75	medium_impact	2.25	0.71	neutral	0.53	neutral	3.94	23.50	deleterious	0.44	0.55	0.58	disease	0.68	disease	0.59	disease	0.72	disease	4	0.94	neutral	0.14	neutral	0	NA	0.72	deleterious	-1.56	low_impact	-0.21	medium_impact	0.75	medium_impact	0.77	0.85	27.55	11.42	0.34	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10492	10492	T	C	MI.15741	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	23	8	I	T	aTt/aCt	-0.86	0	0	benign	0.13	neutral	0.29	neutral	1.76	neutral	-2.24	deleterious	-3.78	low_impact	1.71	0.84	neutral	0.9	neutral	1.17	11.59	neutral	0.58	0.65	0.36	neutral	0.43	neutral	0.58	disease	0.48	neutral	0	0.66	neutral	0.58	deleterious	-6	neutral	0.24	neutral	-0.05	medium_impact	-0.01	medium_impact	0.3	medium_impact	0.76	0.85	27.55	11.42	0.43	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10492	10492	T	G	MI.15742	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	23	8	I	S	aTt/aGt	-0.86	0	0	benign	0.18	neutral	0.32	neutral	1.85	neutral	-1.02	deleterious	-4.72	medium_impact	2.6	0.68	neutral	0.67	neutral	2.16	17.25	deleterious	0.45	0.55	0.41	neutral	0.65	disease	0.5	neutral	0.55	disease	1	0.62	neutral	0.57	deleterious	-3	neutral	0.61	deleterious	-0.2	medium_impact	0.03	medium_impact	1.04	medium_impact	0.75	0.85	27.55	11.42	0.42	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10493	10493	T	G	MI.15743	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	24	8	I	M	atT/atG	3.52	0.28	0	probably_damaging	0.91	neutral	0.34	neutral	1.73	neutral	-2.79	neutral	-1.38	low_impact	1.71	0.82	neutral	0.97	neutral	1.94	15.84	deleterious	0.58	0.65	0.35	neutral	0.37	neutral	0.45	neutral	0.47	neutral	1	0.92	neutral	0.22	neutral	-2	neutral	0.65	deleterious	-1.72	low_impact	0.05	medium_impact	0.3	medium_impact	0.86	0.9	27.55	11.42	0.46	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10493	10493	T	A	MI.15744	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	24	8	I	M	atT/atA	3.52	0.28	0	probably_damaging	0.91	neutral	0.34	neutral	1.73	neutral	-2.79	neutral	-1.38	low_impact	1.71	0.82	neutral	0.97	neutral	2.26	17.93	deleterious	0.58	0.65	0.35	neutral	0.37	neutral	0.45	neutral	0.47	neutral	1	0.92	neutral	0.22	neutral	-2	neutral	0.65	deleterious	-1.72	low_impact	0.05	medium_impact	0.3	medium_impact	0.86	0.9	27.55	11.42	0.46	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10494	10494	A	G	MI.15745	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	25	9	M	V	Ata/Gta	-7.09	0	0	benign	0	neutral	0.52	neutral	2.04	neutral	0.53	neutral	-0.82	low_impact	1.08	0.81	neutral	0.84	neutral	-1.08	0.01	neutral	0.65	0.7	0.14	neutral	0.51	disease	0.57	disease	0.66	disease	3	0.48	neutral	0.76	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.23	medium_impact	-0.23	medium_impact	0.38	0.8	29.59	17.1	0.26	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10494	10494	A	C	MI.15746	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	25	9	M	L	Ata/Cta	-7.09	0	0	benign	0	neutral	1	neutral	2.09	neutral	1.04	neutral	-0.61	neutral_impact	0.16	0.77	neutral	0.98	neutral	-0.87	0.03	neutral	0.58	0.65	0.13	neutral	0.47	neutral	0.41	neutral	0.43	neutral	1	0	neutral	1	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	1.88	high_impact	-1	low_impact	0.46	0.8	29.59	17.1	0.28	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10494	10494	A	T	MI.15747	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	25	9	M	L	Ata/Tta	-7.09	0	0	benign	0	neutral	1	neutral	2.09	neutral	1.04	neutral	-0.61	neutral_impact	0.16	0.77	neutral	0.98	neutral	-0.80	0.04	neutral	0.58	0.65	0.13	neutral	0.47	neutral	0.41	neutral	0.43	neutral	1	0	neutral	1	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	1.88	high_impact	-1	low_impact	0.46	0.8	29.59	17.1	0.28	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10495	10495	T	C	MI.15748	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	26	9	M	T	aTa/aCa	-1.09	0	0	benign	0	neutral	0.41	neutral	2	neutral	0.01	neutral	-1.78	low_impact	0.8	0.84	neutral	0.99	neutral	-1.09	0.01	neutral	0.65	0.7	0.12	neutral	0.26	neutral	0.47	neutral	0.42	neutral	2	0.59	neutral	0.71	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	0.12	medium_impact	-0.47	medium_impact	0.31	0.8	29.59	17.1	0.34	N	0.04	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10495	10495	T	A	MI.15749	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	26	9	M	K	aTa/aAa	-1.09	0	0	benign	0.11	neutral	0.16	neutral	1.93	neutral	-2.17	deleterious	-3.67	medium_impact	2.44	0.81	neutral	0.53	neutral	0.35	6.12	deleterious	0.33	0.5	0.35	neutral	0.75	disease	0.68	disease	0.75	disease	5	0.82	neutral	0.53	deleterious	-3	neutral	0.27	neutral	0.03	medium_impact	-0.19	medium_impact	0.91	medium_impact	0.48	0.8	29.59	17.1	0.34	N	0.60	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8428	8428	C	A	MI.1575	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	63	21	F	L	ttC/ttA	1.29	0	0	probably_damaging	0.96	neutral	1	neutral	2.28	deleterious	-4.27	deleterious	-5.44	low_impact	1.92	0.99	neutral	0.62	neutral	4.52	24.30	deleterious	0.39211194	0.85	0.55	disease	0.4	neutral	0.58	disease	0.24	neutral	5	0.96	neutral	0.52	deleterious	-2	neutral	0.74	deleterious	-2.07	low_impact	1.98	high_impact	0.55	medium_impact	0.43	0.85	NA	NA	0.35	N	0.75	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10496	10496	A	T	MI.15750	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	27	9	M	I	atA/atT	-1.09	0	0	benign	0	neutral	0.56	neutral	2.1	neutral	1.07	neutral	-0.61	neutral_impact	0.08	0.78	neutral	0.99	neutral	-0.41	0.37	neutral	0.49	0.55	0.11	neutral	0.4	neutral	0.39	neutral	0.43	neutral	1	0.44	neutral	0.78	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.27	medium_impact	-1.07	low_impact	0.54	0.8	29.59	17.1	0.33	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10496	10496	A	C	MI.15751	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	27	9	M	I	atA/atC	-1.09	0	0	benign	0	neutral	0.56	neutral	2.1	neutral	1.07	neutral	-0.61	neutral_impact	0.08	0.78	neutral	0.99	neutral	-0.45	0.29	neutral	0.49	0.55	0.11	neutral	0.4	neutral	0.39	neutral	0.43	neutral	1	0.44	neutral	0.78	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.27	medium_impact	-1.07	low_impact	0.54	0.8	29.59	17.1	0.33	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10497	10497	C	G	MI.15752	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	28	10	L	V	Cta/Gta	-7.78	0	0	possibly_damaging	0.9	neutral	0.46	neutral	1.78	neutral	-1.21	neutral	-1.66	low_impact	1.46	0.78	neutral	0.93	neutral	1.61	13.93	neutral	0.5	0.6	0.16	neutral	0.49	neutral	0.41	neutral	0.45	neutral	1	0.89	neutral	0.28	neutral	-3	neutral	0.65	deleterious	-1.68	low_impact	0.17	medium_impact	0.09	medium_impact	0.58	0.8	8.16	13.61	0.28	N	0.24	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10497	10497	C	A	MI.15753	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	28	10	L	M	Cta/Ata	-7.78	0	0	possibly_damaging	0.76	neutral	0.36	neutral	1.67	neutral	-2.66	neutral	-0.75	neutral_impact	0.77	0.8	neutral	0.97	neutral	1.96	15.94	deleterious	0.32	0.5	0.16	neutral	0.2	neutral	0.37	neutral	0.36	neutral	3	0.78	neutral	0.3	neutral	-3	neutral	0.64	deleterious	-1.26	low_impact	0.07	medium_impact	-0.49	medium_impact	0.70	0.85	8.16	13.61	0.35	N	0.05	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10498	10498	T	A	MI.15754	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	29	10	L	Q	cTa/cAa	-3.63	0	0	possibly_damaging	0.63	neutral	0.15	neutral	1.61	deleterious	-4.7	deleterious	-4.24	high_impact	3.51	0.76	neutral	0.29	neutral	3.85	23.40	deleterious	0.22	0.45	0.46	neutral	0.65	disease	0.64	disease	0.73	disease	5	0.86	neutral	0.26	neutral	1	deleterious	0.72	deleterious	-1.02	low_impact	-0.21	medium_impact	1.8	medium_impact	0.76	0.85	8.16	13.61	0.39	N	0.76	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10498	10498	T	G	MI.15755	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	29	10	L	R	cTa/cGa	-3.63	0	0	probably_damaging	0.97	neutral	0.18	neutral	1.62	deleterious	-4.52	deleterious	-4.54	high_impact	3.51	0.72	neutral	0.21	damaging	3.93	23.50	deleterious	0.22	0.45	0.44	neutral	0.88	disease	0.74	disease	0.82	disease	6	0.98	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-2.19	low_impact	-0.16	medium_impact	1.8	medium_impact	0.74	0.85	8.16	13.61	0.35	N	0.81	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10498	10498	T	C	MI.15756	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	29	10	L	P	cTa/cCa	-3.63	0	0	probably_damaging	0.99	neutral	0.16	neutral	1.61	deleterious	-5.1	deleterious	-5.27	high_impact	3.51	0.67	neutral	0.19	damaging	3.66	23.20	deleterious	0.17	0.45	0.54	disease	0.86	disease	0.73	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.80	deleterious	-2.63	low_impact	-0.19	medium_impact	1.8	medium_impact	0.66	0.8	8.16	13.61	0.3	N	0.95	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10500	10500	G	C	MI.15757	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	31	11	A	P	Gca/Cca	-1.09	0	0	probably_damaging	0.96	neutral	0.21	neutral	1.83	deleterious	-3.87	deleterious	-4.91	medium_impact	2.62	0.6	damaging	0.33	neutral	3.57	23.10	deleterious	0.19	0.45	0.73	disease	0.93	disease	0.74	disease	0.85	disease	7	0.98	neutral	0.13	neutral	1	deleterious	0.83	deleterious	-2.07	low_impact	-0.11	medium_impact	1.06	medium_impact	0.82	0.85	56.12	11.69	0.31	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10500	10500	G	T	MI.15758	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	31	11	A	S	Gca/Tca	-1.09	0	0	benign	0.3	neutral	0.42	neutral	1.87	neutral	-1.69	deleterious	-2.92	medium_impact	2	0.82	neutral	0.63	neutral	1.73	14.56	neutral	0.58	0.65	0.51	disease	0.75	disease	0.43	neutral	0.58	disease	2	0.5	neutral	0.56	deleterious	-3	neutral	0.26	neutral	-0.47	medium_impact	0.13	medium_impact	0.54	medium_impact	0.73	0.85	56.12	11.69	0.29	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10500	10500	G	A	MI.15759	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	31	11	A	T	Gca/Aca	-1.09	0	0	benign	0.2	neutral	0.4	neutral	1.92	neutral	-0.9	deleterious	-3.83	low_impact	1.57	0.83	neutral	0.79	neutral	1.06	11.01	neutral	0.59	0.65	0.48	neutral	0.66	disease	0.44	neutral	0.47	neutral	1	0.52	neutral	0.6	deleterious	-6	neutral	0.25	neutral	-0.25	medium_impact	0.11	medium_impact	0.18	medium_impact	0.63	0.8	56.12	11.69	0.31	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8428	8428	C	G	MI.1576	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	63	21	F	L	ttC/ttG	1.29	0	0	probably_damaging	0.96	neutral	1	neutral	2.28	deleterious	-4.27	deleterious	-5.44	low_impact	1.92	0.99	neutral	0.62	neutral	4.20	23.90	deleterious	0.39211194	0.85	0.55	disease	0.4	neutral	0.58	disease	0.24	neutral	5	0.96	neutral	0.52	deleterious	-2	neutral	0.74	deleterious	-2.07	low_impact	1.98	high_impact	0.55	medium_impact	0.43	0.85	NA	NA	0.34	N	0.75	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10501	10501	C	G	MI.15760	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	32	11	A	G	gCa/gGa	1.21	0.17	0	possibly_damaging	0.78	neutral	0.35	neutral	1.83	deleterious	-3.22	deleterious	-3.95	medium_impact	2.33	0.66	neutral	0.55	neutral	3.52	23.10	deleterious	0.39	0.5	0.65	disease	0.82	disease	0.6	disease	0.7	disease	4	0.81	neutral	0.29	neutral	0	NA	0.63	deleterious	-1.31	low_impact	0.06	medium_impact	0.82	medium_impact	0.80	0.85	56.12	11.69	0.34	N	0.81	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10501	10501	C	A	MI.15761	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	32	11	A	E	gCa/gAa	1.21	0.17	0	probably_damaging	0.91	neutral	0.27	neutral	1.83	deleterious	-3.52	deleterious	-4.91	high_impact	3.83	0.64	neutral	0.39	neutral	4.30	24.00	deleterious	0.26	0.45	0.63	disease	0.93	disease	0.72	disease	0.81	disease	6	0.93	neutral	0.18	neutral	2	deleterious	0.76	deleterious	-1.72	low_impact	-0.03	medium_impact	2.07	high_impact	0.64	0.8	56.12	11.69	0.43	N	0.97	polymorphism	0.92	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10501	10501	C	T	MI.15762	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	32	11	A	V	gCa/gTa	1.21	0.17	0	possibly_damaging	0.86	neutral	0.51	neutral	1.94	neutral	-0.64	deleterious	-3.92	low_impact	1.83	0.7	neutral	0.5	neutral	4.09	23.70	deleterious	0.69	0.75	0.27	neutral	0.87	disease	0.49	neutral	0.73	disease	5	0.85	neutral	0.33	neutral	-3	neutral	0.62	deleterious	-1.53	low_impact	0.22	medium_impact	0.4	medium_impact	0.68	0.85	56.12	11.69	0.36	N	0.88	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10503	10503	T	C	MI.15763	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	34	12	F	L	Ttt/Ctt	-6.63	0	0	benign	0.12	neutral	0.65	neutral	1.53	deleterious	-3.06	deleterious	-5.61	medium_impact	2.27	0.64	neutral	0.2	damaging	1.97	16.02	deleterious	0.49	0.55	0.63	disease	0.93	disease	0.67	disease	0.72	disease	4	0.24	neutral	0.77	deleterious	-3	neutral	0.31	neutral	-0.01	medium_impact	0.36	medium_impact	0.77	medium_impact	0.49	0.8	48.98	10.11	0.24	N	0.89	disease_causing	0.63	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10503	10503	T	A	MI.15764	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	34	12	F	I	Ttt/Att	-6.63	0	0	possibly_damaging	0.75	neutral	0.26	neutral	1.53	deleterious	-4.26	deleterious	-5.62	medium_impact	2.8	0.64	neutral	0.19	damaging	4.04	23.70	deleterious	0.27	0.45	0.78	disease	0.95	disease	0.71	disease	0.84	disease	7	0.82	neutral	0.26	neutral	0	NA	0.68	deleterious	-1.24	low_impact	-0.04	medium_impact	1.21	medium_impact	0.54	0.8	48.98	10.11	0.35	N	0.66	disease_causing	0.61	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10503	10503	T	G	MI.15765	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	34	12	F	V	Ttt/Gtt	-6.63	0	0	possibly_damaging	0.83	neutral	0.17	neutral	1.56	deleterious	-4.36	deleterious	-6.44	medium_impact	2.24	0.62	neutral	0.11	damaging	3.78	23.40	deleterious	0.31	0.45	0.79	disease	0.95	disease	0.64	disease	0.79	disease	6	0.91	neutral	0.17	neutral	0	NA	0.72	deleterious	-1.43	low_impact	-0.17	medium_impact	0.74	medium_impact	0.44	0.8	48.98	10.11	0.27	N	0.90	disease_causing	0.77	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10504	10504	T	C	MI.15766	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	35	12	F	S	tTt/tCt	5.83	1	0	probably_damaging	0.94	neutral	0.17	neutral	1.43	deleterious	-5.8	deleterious	-7.44	high_impact	3.6	0.64	neutral	0.14	damaging	4.03	23.70	deleterious	0.27	0.45	0.86	disease	0.94	disease	0.71	disease	0.83	disease	7	0.97	neutral	0.12	neutral	2	deleterious	0.83	deleterious	-1.9	low_impact	-0.17	medium_impact	1.88	medium_impact	0.34	0.8	48.98	10.11	0.61	P	0.97	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10504	10504	T	A	MI.15767	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	35	12	F	Y	tTt/tAt	5.83	1	0	benign	0.08	neutral	0.23	neutral	1.46	deleterious	-3.51	neutral	-1.8	medium_impact	2.08	0.77	neutral	0.83	neutral	2.99	22.20	deleterious	0.24	0.45	0.56	disease	0.88	disease	0.65	disease	0.57	disease	1	0.74	neutral	0.58	deleterious	-3	neutral	0.29	neutral	0.17	medium_impact	-0.08	medium_impact	0.61	medium_impact	0.55	0.8	48.98	10.11	0.59	P	0.85	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10504	10504	T	G	MI.15768	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	35	12	F	C	tTt/tGt	5.83	1	0	probably_damaging	0.98	neutral	0.06	neutral	1.41	deleterious	-7.21	deleterious	-7.44	high_impact	3.86	0.63	neutral	0.12	damaging	3.85	23.40	deleterious	0.28	0.45	0.94	disease	0.94	disease	0.75	disease	0.84	disease	7	1	deleterious	0.04	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	-0.45	medium_impact	2.1	high_impact	0.27	0.8	48.98	10.11	0.58	P	0.96	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10505	10505	T	G	MI.15769	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	36	12	F	L	ttT/ttG	3.75	1	0	benign	0.12	neutral	0.65	neutral	1.53	deleterious	-3.06	deleterious	-5.61	medium_impact	2.27	0.64	neutral	0.2	damaging	2.28	18.04	deleterious	0.49	0.55	0.63	disease	0.93	disease	0.67	disease	0.72	disease	4	0.24	neutral	0.77	deleterious	-3	neutral	0.31	neutral	-0.01	medium_impact	0.36	medium_impact	0.77	medium_impact	0.49	0.8	48.98	10.11	0.49	N	0.89	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8429	8429	C	T	MI.1577	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	64	22	L	F	Ctc/Ttc	-7.04	0	0.01	probably_damaging	0.99	neutral	0.3	neutral	0.62	deleterious	-4.33	neutral	-1.66	low_impact	1.29	0.99	neutral	0.89	neutral	3.78	23.40	deleterious	0.45432647	0.85	0.49	neutral	0.14	neutral	0.3	neutral	0.12	neutral	8	0.99	deleterious	0.16	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	0.08	medium_impact	0.01	medium_impact	0.49	0.85	14.71	8.52	0.53	N	0.36	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10505	10505	T	A	MI.15770	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	36	12	F	L	ttT/ttA	3.75	1	0	benign	0.12	neutral	0.65	neutral	1.53	deleterious	-3.06	deleterious	-5.61	medium_impact	2.27	0.64	neutral	0.2	damaging	2.40	18.80	deleterious	0.49	0.55	0.63	disease	0.93	disease	0.67	disease	0.72	disease	4	0.24	neutral	0.77	deleterious	-3	neutral	0.31	neutral	-0.01	medium_impact	0.36	medium_impact	0.77	medium_impact	0.49	0.8	48.98	10.11	0.49	N	0.89	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10506	10506	A	C	MI.15771	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	37	13	T	P	Acc/Ccc	-5.47	0	0	possibly_damaging	0.55	neutral	0.1	neutral	1.89	deleterious	-3.28	deleterious	-2.94	medium_impact	2.96	0.7	neutral	0.32	neutral	2.97	22.10	deleterious	0.19	0.45	0.49	neutral	0.9	disease	0.7	disease	0.81	disease	6	0.89	neutral	0.28	neutral	0	NA	0.60	deleterious	-0.88	medium_impact	-0.32	medium_impact	1.34	medium_impact	0.53	0.8	14.29	11.87	0.32	N	0.89	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10506	10506	A	G	MI.15772	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	37	13	T	A	Acc/Gcc	-5.47	0	0	benign	0.01	neutral	0.29	neutral	2	neutral	0.03	neutral	-1.12	low_impact	1.02	0.86	neutral	1	neutral	-0.26	0.81	neutral	0.55	0.6	0.16	neutral	0.49	neutral	0.47	neutral	0.46	neutral	1	0.7	neutral	0.64	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	-0.01	medium_impact	-0.28	medium_impact	0.50	0.8	14.29	11.87	0.3	N	0.12	polymorphism	1	0.03	rs199688733	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10506	10506	A	T	MI.15773	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	37	13	T	S	Acc/Tcc	-5.47	0	0	benign	0.02	neutral	0.5	neutral	1.97	neutral	-0.41	neutral	-0.99	neutral_impact	0.3	0.85	neutral	0.98	neutral	-0.09	1.80	neutral	0.4	0.5	0.19	neutral	0.42	neutral	0.34	neutral	0.45	neutral	1	0.48	neutral	0.74	deleterious	-6	neutral	0.10	neutral	0.75	medium_impact	0.21	medium_impact	-0.89	medium_impact	0.49	0.8	14.29	11.87	0.34	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10507	10507	C	T	MI.15774	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	38	13	T	I	aCc/aTc	-5.24	0	0	benign	0.01	neutral	0.81	neutral	2.03	neutral	0.35	neutral	-0.56	neutral_impact	-0.24	0.84	neutral	0.99	neutral	-0.49	0.24	neutral	0.58	0.65	0.11	neutral	0.54	disease	0.32	neutral	0.43	neutral	1	0.16	neutral	0.9	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	0.56	medium_impact	-1.34	low_impact	0.56	0.8	14.29	11.87	0.26	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10507	10507	C	G	MI.15775	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	38	13	T	S	aCc/aGc	-5.24	0	0	benign	0.02	neutral	0.5	neutral	1.97	neutral	-0.41	neutral	-0.99	neutral_impact	0.3	0.85	neutral	0.98	neutral	0.13	3.95	deleterious	0.4	0.5	0.19	neutral	0.42	neutral	0.34	neutral	0.45	neutral	1	0.48	neutral	0.74	deleterious	-6	neutral	0.10	neutral	0.75	medium_impact	0.21	medium_impact	-0.89	medium_impact	0.49	0.8	14.29	11.87	0.36	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10507	10507	C	A	MI.15776	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	38	13	T	N	aCc/aAc	-5.24	0	0	benign	0.38	neutral	0.15	neutral	1.89	neutral	-2.98	neutral	-2.38	medium_impact	2.96	0.85	neutral	0.53	neutral	3.15	22.60	deleterious	0.57	0.65	0.42	neutral	0.72	disease	0.59	disease	0.73	disease	5	0.82	neutral	0.39	neutral	-3	neutral	0.32	neutral	-0.61	medium_impact	-0.21	medium_impact	1.34	medium_impact	0.72	0.85	14.29	11.87	0.35	N	0.59	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10509	10509	A	C	MI.15777	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	40	14	I	L	Atc/Ctc	-10.78	0	0	benign	0.12	neutral	1	neutral	1.82	neutral	-0.77	neutral	-0.13	neutral_impact	-0.35	0.77	neutral	0.97	neutral	-0.95	0.02	neutral	0.36	0.5	0.17	neutral	0.33	neutral	0.29	neutral	0.45	neutral	1	0.11	neutral	0.94	deleterious	-6	neutral	0.11	neutral	-0.01	medium_impact	1.88	high_impact	-1.43	low_impact	0.68	0.85	31.63	17.67	0.27	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10509	10509	A	T	MI.15778	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	40	14	I	F	Atc/Ttc	-10.78	0	0	possibly_damaging	0.72	neutral	0.66	neutral	1.59	deleterious	-3.07	neutral	-1.64	neutral_impact	0.5	0.76	neutral	0.93	neutral	2.19	17.43	deleterious	0.42	0.55	0.23	neutral	0.71	disease	0.43	neutral	0.58	disease	2	0.66	neutral	0.47	deleterious	-3	neutral	0.43	neutral	-1.18	low_impact	0.37	medium_impact	-0.72	medium_impact	0.69	0.85	31.63	17.67	0.29	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10509	10509	A	G	MI.15779	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	40	14	I	V	Atc/Gtc	-10.78	0	0	benign	0.29	neutral	0.41	neutral	1.67	neutral	-1.83	neutral	-0.25	neutral_impact	0.22	0.84	neutral	0.99	neutral	-0.19	1.15	neutral	0.6	0.65	0.11	neutral	0.47	neutral	0.41	neutral	0.44	neutral	1	0.51	neutral	0.56	deleterious	-6	neutral	0.14	neutral	-0.45	medium_impact	0.12	medium_impact	-0.95	medium_impact	0.48	0.8	31.63	17.67	0.3	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8429	8429	C	G	MI.1578	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	64	22	L	V	Ctc/Gtc	-7.04	0	0.01	probably_damaging	0.97	neutral	0.55	neutral	0.69	deleterious	-3.33	neutral	-0.25	medium_impact	1.99	1	neutral	0.75	neutral	3.23	22.80	deleterious	0.47385093	0.85	0.24	neutral	0.14	neutral	0.29	neutral	0.12	neutral	8	0.97	neutral	0.29	neutral	1	deleterious	0.69	deleterious	-2.19	low_impact	0.34	medium_impact	0.61	medium_impact	0.67	0.85	14.71	8.52	0.39	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10510	10510	T	C	MI.15780	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	41	14	I	T	aTc/aCc	-3.17	0	0	benign	0.04	neutral	0.17	neutral	1.59	deleterious	-3.12	neutral	-1.92	low_impact	1.93	0.86	neutral	0.97	neutral	0.14	4.02	deleterious	0.67	0.7	0.44	neutral	0.57	disease	0.46	neutral	0.49	neutral	0	0.82	neutral	0.57	deleterious	-6	neutral	0.16	neutral	0.46	medium_impact	-0.17	medium_impact	0.48	medium_impact	0.65	0.8	31.63	17.67	0.44	N	0.53	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10510	10510	T	A	MI.15781	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	41	14	I	N	aTc/aAc	-3.17	0	0	possibly_damaging	0.72	neutral	0.1	neutral	1.54	deleterious	-5.09	deleterious	-3.99	medium_impact	3.18	0.73	neutral	0.4	neutral	3.95	23.60	deleterious	0.4	0.5	0.71	disease	0.84	disease	0.62	disease	0.81	disease	6	0.92	neutral	0.19	neutral	0	NA	0.56	deleterious	-1.18	low_impact	-0.32	medium_impact	1.53	medium_impact	0.65	0.8	31.63	17.67	0.35	N	0.84	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10510	10510	T	G	MI.15782	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	41	14	I	S	aTc/aGc	-3.17	0	0	benign	0.4	neutral	0.28	neutral	1.63	neutral	-2.4	deleterious	-2.84	low_impact	1.28	0.69	neutral	0.57	neutral	3.75	23.30	deleterious	0.41	0.5	0.55	disease	0.8	disease	0.45	neutral	0.71	disease	4	0.67	neutral	0.44	neutral	-6	neutral	0.34	neutral	-0.64	medium_impact	-0.02	medium_impact	-0.07	medium_impact	0.57	0.8	31.63	17.67	0.3	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10511	10511	C	G	MI.15783	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	42	14	I	M	atC/atG	1.44	0	0	benign	0.08	neutral	0.34	neutral	1.59	deleterious	-3.09	neutral	-0.02	neutral_impact	0.65	0.82	neutral	0.98	neutral	0.10	3.60	deleterious	0.45	0.55	0.27	neutral	0.51	disease	0.35	neutral	0.46	neutral	1	0.62	neutral	0.63	deleterious	-6	neutral	0.14	neutral	0.17	medium_impact	0.05	medium_impact	-0.59	medium_impact	0.77	0.85	31.63	17.67	0.43	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10511	10511	C	A	MI.15784	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	42	14	I	M	atC/atA	1.44	0	0	benign	0.08	neutral	0.34	neutral	1.59	deleterious	-3.09	neutral	-0.02	neutral_impact	0.65	0.82	neutral	0.98	neutral	0.51	7.54	deleterious	0.45	0.55	0.27	neutral	0.51	disease	0.35	neutral	0.46	neutral	1	0.62	neutral	0.63	deleterious	-6	neutral	0.14	neutral	0.17	medium_impact	0.05	medium_impact	-0.59	medium_impact	0.77	0.85	31.63	17.67	0.42	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10512	10512	T	G	MI.15785	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	43	15	S	A	Tca/Gca	-7.78	0	0	benign	0.3	neutral	0.51	neutral	1.98	neutral	-0.19	neutral	-1.25	neutral_impact	0.6	0.77	neutral	0.96	neutral	1.95	15.92	deleterious	0.57	0.65	0.23	neutral	0.55	disease	0.4	neutral	0.45	neutral	1	0.39	neutral	0.61	deleterious	-6	neutral	0.72	deleterious	-0.47	medium_impact	0.22	medium_impact	-0.64	medium_impact	0.72	0.85	48.98	8.72	0.31	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10512	10512	T	C	MI.15786	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	43	15	S	P	Tca/Cca	-7.78	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.81	deleterious	-3.7	deleterious	-4.04	medium_impact	3.32	0.7	neutral	0.13	damaging	3.73	23.30	deleterious	0.25	0.45	0.64	disease	0.95	disease	0.69	disease	0.85	disease	7	0.99	deleterious	0.11	neutral	1	deleterious	0.88	deleterious	-2.63	low_impact	-0.12	medium_impact	1.65	medium_impact	0.65	0.8	48.98	8.72	0.31	N	0.87	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10512	10512	T	A	MI.15787	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	43	15	S	T	Tca/Aca	-7.78	0	0	probably_damaging	0.92	neutral	0.39	neutral	1.83	neutral	-2.38	neutral	-2.19	medium_impact	2.23	0.74	neutral	0.39	neutral	3.48	23.10	deleterious	0.49	0.55	0.42	neutral	0.68	disease	0.45	neutral	0.52	disease	0	0.93	neutral	0.24	neutral	1	deleterious	0.76	deleterious	-1.78	low_impact	0.1	medium_impact	0.73	medium_impact	0.72	0.85	48.98	8.72	0.33	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10513	10513	C	G	MI.15788	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	44	15	S	W	tCa/tGa	0.29	0.06	0	probably_damaging	1	neutral	0.19	neutral	1.79	deleterious	-6.47	deleterious	-6	high_impact	3.66	0.68	neutral	0.1	damaging	4.14	23.80	deleterious	0.2	0.45	0.93	disease	0.95	disease	0.67	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.14	medium_impact	1.93	medium_impact	0.48	0.8	48.98	8.72	0.31	N	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10513	10513	C	T	MI.15789	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	44	15	S	L	tCa/tTa	0.29	0.06	0	probably_damaging	0.94	neutral	0.65	neutral	1.82	deleterious	-3.14	deleterious	-4.73	medium_impact	2.28	0.69	neutral	0.15	damaging	4.47	24.20	deleterious	0.34	0.5	0.67	disease	0.92	disease	0.54	disease	0.77	disease	5	0.93	neutral	0.36	neutral	1	deleterious	0.84	deleterious	-1.9	low_impact	0.36	medium_impact	0.77	medium_impact	0.81	0.85	48.98	8.72	0.25	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8429	8429	C	A	MI.1579	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	64	22	L	I	Ctc/Atc	-7.04	0	0.01	probably_damaging	0.97	neutral	1	neutral	0.76	neutral	-2.75	neutral	0.56	neutral_impact	0.4	0.97	neutral	0.92	neutral	1.57	13.67	neutral	0.45672233	0.85	0.1	neutral	0.05	neutral	0.19	neutral	0.04	neutral	9	0.97	neutral	0.52	deleterious	-2	neutral	0.66	deleterious	-2.19	low_impact	1.98	high_impact	-0.76	medium_impact	0.60	0.85	14.71	8.52	0.39	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10515	10515	C	A	MI.15790	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	46	16	L	I	Ctt/Att	-8.01	0	0	possibly_damaging	0.9	neutral	0.46	neutral	1.82	neutral	-0.93	neutral	-1.66	low_impact	1.68	0.74	neutral	0.49	neutral	2.82	21.50	deleterious	0.51	0.6	0.4	neutral	0.58	disease	0.39	neutral	0.49	neutral	0	0.89	neutral	0.28	neutral	-3	neutral	0.73	deleterious	-1.68	low_impact	0.17	medium_impact	0.27	medium_impact	0.64	0.8	48.98	9.49	0.36	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10515	10515	C	G	MI.15791	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	46	16	L	V	Ctt/Gtt	-8.01	0	0	possibly_damaging	0.9	neutral	0.49	neutral	1.81	neutral	-1.06	deleterious	-2.62	medium_impact	2.08	0.77	neutral	0.29	neutral	3.19	22.70	deleterious	0.51	0.6	0.4	neutral	0.71	disease	0.46	neutral	0.54	disease	1	0.89	neutral	0.3	neutral	0	NA	0.75	deleterious	-1.68	low_impact	0.2	medium_impact	0.61	medium_impact	0.61	0.8	48.98	9.49	0.22	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10515	10515	C	T	MI.15792	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	46	16	L	F	Ctt/Ttt	-8.01	0	0	possibly_damaging	0.5	neutral	0.61	neutral	1.7	neutral	-2.08	neutral	-2.45	low_impact	1.06	0.78	neutral	0.95	neutral	0.94	10.29	neutral	0.53	0.6	0.3	neutral	0.66	disease	0.47	neutral	0.49	neutral	0	0.43	neutral	0.56	deleterious	-3	neutral	0.73	deleterious	-0.8	medium_impact	0.32	medium_impact	-0.25	medium_impact	0.64	0.8	48.98	9.49	0.24	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10516	10516	T	C	MI.15793	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	47	16	L	P	cTt/cCt	-1.78	0	0	probably_damaging	1	neutral	0.09	neutral	1.61	deleterious	-5.11	deleterious	-6.41	high_impact	3.96	0.64	neutral	0.09	damaging	3.72	23.30	deleterious	0.21	0.45	0.8	disease	0.93	disease	0.75	disease	0.88	disease	8	1	deleterious	0.05	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.35	medium_impact	2.18	high_impact	0.56	0.8	48.98	9.49	0.33	N	0.95	polymorphism	0.83	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10516	10516	T	G	MI.15794	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	47	16	L	R	cTt/cGt	-1.78	0	0	probably_damaging	0.99	neutral	0.16	neutral	1.62	deleterious	-4.55	deleterious	-5.43	high_impact	3.96	0.7	neutral	0.09	damaging	4.02	23.60	deleterious	0.21	0.45	0.73	disease	0.93	disease	0.75	disease	0.88	disease	8	0.99	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-2.63	low_impact	-0.19	medium_impact	2.18	high_impact	0.62	0.8	48.98	9.49	0.34	N	0.98	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10516	10516	T	A	MI.15795	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	47	16	L	H	cTt/cAt	-1.78	0	0	probably_damaging	1	neutral	0.26	neutral	1.61	deleterious	-5.08	deleterious	-5.98	high_impact	3.96	0.74	neutral	0.12	damaging	4.04	23.70	deleterious	0.24	0.45	0.77	disease	0.89	disease	0.72	disease	0.8	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.04	medium_impact	2.18	high_impact	0.51	0.8	48.98	9.49	0.31	N	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10518	10518	C	A	MI.15796	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	49	17	L	M	Cta/Ata	-14	0	0	probably_damaging	0.95	neutral	0.31	neutral	1.82	neutral	-1.58	neutral	-0.92	low_impact	0.93	0.79	neutral	0.97	neutral	1.97	16.04	deleterious	0.42	0.55	0.27	neutral	0.14	neutral	0.31	neutral	0.28	neutral	4	0.96	neutral	0.18	neutral	-2	neutral	0.64	deleterious	-1.97	low_impact	0.02	medium_impact	-0.36	medium_impact	0.65	0.8	20.41	17.97	0.42	N	0.05	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10518	10518	C	G	MI.15797	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	49	17	L	V	Cta/Gta	-14	0	0	benign	0.12	neutral	0.57	neutral	1.85	neutral	-1.15	neutral	-1.52	low_impact	0.94	0.8	neutral	0.96	neutral	2.00	16.18	deleterious	0.48	0.55	0.17	neutral	0.46	neutral	0.37	neutral	0.45	neutral	1	0.33	neutral	0.73	deleterious	-6	neutral	0.65	deleterious	-0.01	medium_impact	0.28	medium_impact	-0.35	medium_impact	0.57	0.8	20.41	17.97	0.32	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10519	10519	T	C	MI.15798	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	50	17	L	P	cTa/cCa	-1.55	0	0	probably_damaging	0.96	neutral	0.19	neutral	1.73	deleterious	-4.52	deleterious	-5.4	high_impact	3.64	0.66	neutral	0.21	damaging	3.69	23.30	deleterious	0.3	0.45	0.57	disease	0.9	disease	0.73	disease	0.83	disease	7	0.98	neutral	0.12	neutral	2	deleterious	0.83	deleterious	-2.07	low_impact	-0.14	medium_impact	1.91	medium_impact	0.56	0.8	20.41	17.97	0.33	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10519	10519	T	A	MI.15799	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	50	17	L	Q	cTa/cAa	-1.55	0	0	probably_damaging	0.96	neutral	0.28	neutral	1.74	deleterious	-4.13	deleterious	-4.55	high_impact	3.64	0.8	neutral	0.19	damaging	3.82	23.40	deleterious	0.3	0.45	0.5	neutral	0.72	disease	0.61	disease	0.73	disease	5	0.97	neutral	0.16	neutral	2	deleterious	0.73	deleterious	-2.07	low_impact	-0.02	medium_impact	1.91	medium_impact	0.56	0.8	20.41	17.97	0.32	N	0.84	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8600	8600	T	C	MI.158	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	74	25	L	P	cTa/cCa	-2.19	0	0	probably_damaging	1	deleterious	0.04	neutral	4.25	neutral	-1.12	deleterious	-3.88	medium_impact	2.65	0.77	neutral	0.51	neutral	3.63	23.20	deleterious	0.19	0.65	0.88	disease	0.69	disease	0.69	disease	0.75	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.49	medium_impact	1.17	medium_impact	0.61	0.9	10.18	13.06	0.28	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8430	8430	T	A	MI.1580	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	65	22	L	H	cTc/cAc	-3.11	0	0	probably_damaging	1	deleterious	0.03	neutral	0.56	deleterious	-7.74	deleterious	-4.42	medium_impact	2.44	0.99	neutral	0.74	neutral	3.99	23.60	deleterious	0.26709301	0.85	0.87	disease	0.42	neutral	0.4	neutral	0.26	neutral	5	1	deleterious	0.02	neutral	5	deleterious	0.81	deleterious	-3.6	low_impact	-0.56	medium_impact	0.99	medium_impact	0.59	0.85	14.71	8.52	0.54	P	0.62	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10519	10519	T	G	MI.15800	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	50	17	L	R	cTa/cGa	-1.55	0	0	probably_damaging	0.95	neutral	0.39	neutral	1.74	deleterious	-3.95	deleterious	-4.76	high_impact	3.64	0.72	neutral	0.12	damaging	3.98	23.60	deleterious	0.28	0.45	0.48	neutral	0.88	disease	0.72	disease	0.81	disease	6	0.95	neutral	0.22	neutral	2	deleterious	0.80	deleterious	-1.97	low_impact	0.1	medium_impact	1.91	medium_impact	0.61	0.8	20.41	17.97	0.31	N	0.94	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10521	10521	G	T	MI.15801	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	52	18	G	W	Gga/Tga	-2.94	0	0	probably_damaging	1	neutral	0.19	neutral	1.54	deleterious	-7.27	deleterious	-7.9	high_impact	4.41	0.57	damaging	0.04	damaging	4.22	23.90	deleterious	0.18	0.45	0.92	disease	0.95	disease	0.73	disease	0.83	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.14	medium_impact	2.56	high_impact	0.38	0.8	53.06	11.91	0.41	N	0.99	disease_causing	0.79	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10521	10521	G	C	MI.15802	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	52	18	G	R	Gga/Cga	-2.94	0	0	probably_damaging	1	neutral	0.35	neutral	1.56	deleterious	-4.69	deleterious	-7.86	high_impact	4.41	0.54	damaging	0.04	damaging	3.71	23.30	deleterious	0.21	0.45	0.73	disease	0.95	disease	0.79	disease	0.89	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.06	medium_impact	2.56	high_impact	0.78	0.85	53.06	11.91	0.51	N	0.99	disease_causing	0.69	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10522	10522	G	C	MI.15803	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	53	18	G	A	gGa/gCa	7.21	1	0	probably_damaging	1	neutral	0.51	neutral	1.63	neutral	-2.92	deleterious	-5.9	medium_impact	3.02	0.67	neutral	0.14	damaging	2.94	22.00	deleterious	0.31	0.5	0.38	neutral	0.83	disease	0.55	disease	0.7	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	0.22	medium_impact	1.39	medium_impact	0.75	0.85	53.06	11.91	0.47	N	0.98	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10522	10522	G	A	MI.15804	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	53	18	G	E	gGa/gAa	7.21	1	0	probably_damaging	1	neutral	0.27	neutral	1.56	deleterious	-4.44	deleterious	-7.81	high_impact	4.41	0.62	neutral	0.06	damaging	3.70	23.30	deleterious	0.17	0.45	0.73	disease	0.94	disease	0.78	disease	0.85	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.03	medium_impact	2.56	high_impact	0.62	0.8	53.06	11.91	0.7	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10522	10522	G	T	MI.15805	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	53	18	G	V	gGa/gTa	7.21	1	0	probably_damaging	1	neutral	0.5	neutral	1.67	deleterious	-3.23	deleterious	-8.87	medium_impact	2.45	0.61	neutral	0.04	damaging	3.57	23.10	deleterious	0.2	0.45	0.26	neutral	0.94	disease	0.59	disease	0.78	disease	6	1	deleterious	0.25	neutral	1	deleterious	0.80	deleterious	-3.55	low_impact	0.21	medium_impact	0.92	medium_impact	0.57	0.8	53.06	11.91	0.42	N	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10524	10524	A	G	MI.15806	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	55	19	M	V	Ata/Gta	-15.39	0	0	benign	0.01	neutral	0.45	neutral	2.25	neutral	2.14	neutral	-0.71	neutral_impact	-0.02	0.81	neutral	0.97	neutral	-0.53	0.19	neutral	0.74	0.8	0.13	neutral	0.58	disease	0.41	neutral	0.45	neutral	1	0.54	neutral	0.72	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	0.16	medium_impact	-1.16	low_impact	0.50	0.8	34.69	22.61	0.3	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10524	10524	A	T	MI.15807	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	55	19	M	L	Ata/Tta	-15.39	0	0	benign	0.01	neutral	1	neutral	2.35	neutral	2.58	neutral	-0.23	neutral_impact	-1.21	0.79	neutral	0.99	neutral	-1.35	0.00	neutral	0.65	0.7	0.22	neutral	0.33	neutral	0.34	neutral	0.43	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	1.88	high_impact	-2.15	low_impact	0.54	0.8	34.69	22.61	0.34	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10524	10524	A	C	MI.15808	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	55	19	M	L	Ata/Cta	-15.39	0	0	benign	0.01	neutral	1	neutral	2.35	neutral	2.58	neutral	-0.23	neutral_impact	-1.21	0.79	neutral	0.99	neutral	-1.46	0.00	neutral	0.65	0.7	0.22	neutral	0.33	neutral	0.34	neutral	0.43	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	1.88	high_impact	-2.15	low_impact	0.54	0.8	34.69	22.61	0.33	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10525	10525	T	A	MI.15809	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	56	19	M	K	aTa/aAa	-1.55	0	0	benign	0.34	neutral	0.26	neutral	1.93	neutral	-2.45	deleterious	-3.42	medium_impact	2.6	0.68	neutral	0.45	neutral	3.70	23.30	deleterious	0.35	0.5	0.34	neutral	0.81	disease	0.68	disease	0.8	disease	6	0.69	neutral	0.46	neutral	-3	neutral	0.53	deleterious	-0.54	medium_impact	-0.04	medium_impact	1.04	medium_impact	0.58	0.8	34.69	22.61	0.35	N	0.72	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8430	8430	T	C	MI.1581	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	65	22	L	P	cTc/cCc	-3.11	0	0	probably_damaging	1	deleterious	0.01	neutral	0.56	deleterious	-7.36	deleterious	-5	medium_impact	2.79	0.99	neutral	0.39	neutral	3.76	23.30	deleterious	0.17080650	0.85	0.83	disease	0.54	disease	0.64	disease	0.61	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	1.29	medium_impact	0.54	0.85	14.71	8.52	0.51	N	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10525	10525	T	C	MI.15810	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	56	19	M	T	aTa/aCa	-1.55	0	0	benign	0.02	neutral	0.31	neutral	1.99	neutral	-0.25	neutral	-1.55	neutral_impact	0.31	0.83	neutral	0.99	neutral	-0.15	1.41	neutral	0.66	0.7	0.12	neutral	0.43	neutral	0.44	neutral	0.45	neutral	1	0.68	neutral	0.65	deleterious	-6	neutral	0.29	neutral	0.75	medium_impact	0.02	medium_impact	-0.88	medium_impact	0.41	0.8	34.69	22.61	0.35	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10526	10526	A	T	MI.15811	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	57	19	M	I	atA/atT	2.83	0.12	0	benign	0.01	neutral	0.44	neutral	2.23	neutral	2.04	neutral	-0.64	neutral_impact	0.66	0.78	neutral	0.93	neutral	0.20	4.69	deleterious	0.56	0.6	0.14	neutral	0.65	disease	0.39	neutral	0.53	disease	1	0.55	neutral	0.72	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.15	medium_impact	-0.59	medium_impact	0.59	0.8	34.69	22.61	0.36	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10526	10526	A	C	MI.15812	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	57	19	M	I	atA/atC	2.83	0.12	0	benign	0.01	neutral	0.44	neutral	2.23	neutral	2.04	neutral	-0.64	neutral_impact	0.66	0.78	neutral	0.93	neutral	0.15	4.16	deleterious	0.56	0.6	0.14	neutral	0.65	disease	0.39	neutral	0.53	disease	1	0.55	neutral	0.72	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.15	medium_impact	-0.59	medium_impact	0.59	0.8	34.69	22.61	0.36	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10527	10527	C	G	MI.15813	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	58	20	L	V	Cta/Gta	-5.93	0	0.01	possibly_damaging	0.9	neutral	0.61	neutral	1.62	neutral	-2.18	neutral	-2.35	low_impact	1.54	0.78	neutral	0.32	neutral	2.05	16.51	deleterious	0.69	0.75	0.12	neutral	0.49	neutral	0.29	neutral	0.43	neutral	1	0.88	neutral	0.36	neutral	-3	neutral	0.60	deleterious	-1.68	low_impact	0.32	medium_impact	0.15	medium_impact	0.72	0.85	51.02	8.89	0.2	N	0.48	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10527	10527	C	A	MI.15814	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	58	20	L	M	Cta/Ata	-5.93	0	0.01	probably_damaging	0.99	neutral	0.25	neutral	1.58	neutral	-2.71	neutral	-0.84	medium_impact	2.25	0.8	neutral	0.87	neutral	2.05	16.51	deleterious	0.44	0.55	0.4	neutral	0.34	neutral	0.32	neutral	0.46	neutral	1	0.99	deleterious	0.13	neutral	1	deleterious	0.68	deleterious	-2.63	low_impact	-0.06	medium_impact	0.75	medium_impact	0.70	0.85	51.02	8.89	0.42	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10528	10528	T	A	MI.15815	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	59	20	L	Q	cTa/cAa	-1.78	0	0	probably_damaging	0.99	neutral	0.3	neutral	1.52	deleterious	-4.47	deleterious	-4.82	high_impact	3.88	0.69	neutral	0.12	damaging	4.14	23.80	deleterious	0.29	0.45	0.55	disease	0.73	disease	0.48	neutral	0.52	disease	0	0.99	deleterious	0.16	neutral	2	deleterious	0.77	deleterious	-2.63	low_impact	0.01	medium_impact	2.11	high_impact	0.69	0.85	51.02	8.89	0.36	N	0.95	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10528	10528	T	C	MI.15816	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	59	20	L	P	cTa/cCa	-1.78	0	0	probably_damaging	0.99	neutral	0.19	neutral	1.5	deleterious	-5.5	deleterious	-6	high_impact	3.88	0.57	damaging	0.07	damaging	3.74	23.30	deleterious	0.24	0.45	0.63	disease	0.89	disease	0.63	disease	0.79	disease	6	0.99	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-2.63	low_impact	-0.14	medium_impact	2.11	high_impact	0.46	0.8	51.02	8.89	0.3	N	0.95	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10528	10528	T	G	MI.15817	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	59	20	L	R	cTa/cGa	-1.78	0	0	probably_damaging	0.98	neutral	0.43	neutral	1.51	deleterious	-4.93	deleterious	-5	high_impact	3.88	0.65	neutral	0.07	damaging	3.98	23.60	deleterious	0.3	0.45	0.54	disease	0.87	disease	0.62	disease	0.79	disease	6	0.98	deleterious	0.23	neutral	2	deleterious	0.81	deleterious	-2.35	low_impact	0.14	medium_impact	2.11	high_impact	0.69	0.85	51.02	8.89	0.27	N	0.98	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10530	10530	G	T	MI.15818	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	61	21	V	L	Gta/Tta	-5.24	0	0	benign	0.03	neutral	0.67	neutral	2.12	neutral	0.26	neutral	0.15	neutral_impact	-0.08	0.71	neutral	0.97	neutral	0.08	3.41	deleterious	0.75	0.8	0.11	neutral	0.27	neutral	0.2	neutral	0.42	neutral	2	0.29	neutral	0.82	deleterious	-6	neutral	0.12	neutral	0.58	medium_impact	0.38	medium_impact	-1.21	low_impact	0.75	0.85	26.53	16.25	0.36	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10530	10530	G	C	MI.15819	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	61	21	V	L	Gta/Cta	-5.24	0	0	benign	0.03	neutral	0.67	neutral	2.12	neutral	0.26	neutral	0.15	neutral_impact	-0.08	0.71	neutral	0.97	neutral	-0.08	1.89	neutral	0.75	0.8	0.11	neutral	0.27	neutral	0.2	neutral	0.42	neutral	2	0.29	neutral	0.82	deleterious	-6	neutral	0.12	neutral	0.58	medium_impact	0.38	medium_impact	-1.21	low_impact	0.75	0.85	26.53	16.25	0.36	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8430	8430	T	G	MI.1582	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	65	22	L	R	cTc/cGc	-3.11	0	0	probably_damaging	1	deleterious	0.02	neutral	0.56	deleterious	-7.07	deleterious	-4.58	medium_impact	2.79	1	neutral	0.49	neutral	4.05	23.70	deleterious	0.16376862	0.85	0.79	disease	0.57	disease	0.63	disease	0.61	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-3.6	low_impact	-0.66	medium_impact	1.29	medium_impact	0.62	0.85	14.71	8.52	0.53	N	0.68	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10530	10530	G	A	MI.15820	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	61	21	V	M	Gta/Ata	-5.24	0	0	benign	0.02	neutral	0.26	neutral	1.95	neutral	-1.41	neutral	0.68	neutral_impact	-0.8	0.8	neutral	0.98	neutral	-0.25	0.88	neutral	0.65	0.7	0.11	neutral	0.2	neutral	0.22	neutral	0.35	neutral	3	0.73	neutral	0.62	deleterious	-6	neutral	0.12	neutral	0.75	medium_impact	-0.04	medium_impact	-1.81	low_impact	0.81	0.85	26.53	16.25	0.36	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10531	10531	T	G	MI.15821	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	62	21	V	G	gTa/gGa	-0.86	0	0	benign	0.34	neutral	0.22	neutral	1.88	deleterious	-3.13	deleterious	-5.18	low_impact	1.71	0.75	neutral	0.47	neutral	1.85	15.26	deleterious	0.42	0.55	0.42	neutral	0.6	disease	0.47	neutral	0.54	disease	1	0.74	neutral	0.44	neutral	-6	neutral	0.41	neutral	-0.54	medium_impact	-0.1	medium_impact	0.3	medium_impact	0.63	0.8	26.53	16.25	0.37	N	0.68	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10531	10531	T	C	MI.15822	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	62	21	V	A	gTa/gCa	-0.86	0	0	benign	0.12	neutral	0.35	neutral	1.95	neutral	-1.39	deleterious	-2.65	low_impact	1.12	0.75	neutral	0.76	neutral	1.52	13.39	neutral	0.74	0.75	0.21	neutral	0.32	neutral	0.37	neutral	0.46	neutral	1	0.6	neutral	0.62	deleterious	-6	neutral	0.22	neutral	-0.01	medium_impact	0.06	medium_impact	-0.2	medium_impact	0.48	0.8	26.53	16.25	0.44	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10531	10531	T	A	MI.15823	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	62	21	V	E	gTa/gAa	-0.86	0	0	benign	0.34	neutral	0.15	neutral	1.88	deleterious	-3.15	deleterious	-4.2	medium_impact	2.52	0.72	neutral	0.45	neutral	2.99	22.20	deleterious	0.32	0.5	0.42	neutral	0.74	disease	0.52	disease	0.64	disease	3	0.82	neutral	0.41	neutral	-3	neutral	0.58	deleterious	-0.54	medium_impact	-0.21	medium_impact	0.97	medium_impact	0.53	0.8	26.53	16.25	0.39	N	0.62	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10533	10533	T	A	MI.15824	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	64	22	Y	N	Tat/Aat	-5.93	0	0	probably_damaging	1	neutral	0.36	neutral	2.07	neutral	1.59	deleterious	-7.94	neutral_impact	0.62	0.76	neutral	0.8	neutral	2.75	21.10	deleterious	0.58	0.65	0.14	neutral	0.66	disease	0.37	neutral	0.44	neutral	1	1	deleterious	0.18	neutral	-2	neutral	0.70	deleterious	-3.55	low_impact	0.07	medium_impact	-0.62	medium_impact	0.40	0.8	25.51	12.02	0.3	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10533	10533	T	C	MI.15825	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	64	22	Y	H	Tat/Cat	-5.93	0	0	probably_damaging	1	neutral	0.73	neutral	2.03	neutral	0.39	deleterious	-4.61	low_impact	1.2	0.71	neutral	0.88	neutral	0.68	8.68	deleterious	0.76	0.8	0.21	neutral	0.22	neutral	0.26	neutral	0.39	neutral	2	1	deleterious	0.37	neutral	-2	neutral	0.68	deleterious	-3.55	low_impact	0.45	medium_impact	-0.13	medium_impact	0.44	0.8	25.51	12.02	0.31	N	0.79	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10533	10533	T	G	MI.15826	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	64	22	Y	D	Tat/Gat	-5.93	0	0	probably_damaging	1	neutral	0.19	neutral	1.98	neutral	0.28	deleterious	-8.62	medium_impact	3.29	0.8	neutral	0.39	neutral	3.81	23.40	deleterious	0.54	0.6	0.32	neutral	0.88	disease	0.62	disease	0.8	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	-0.14	medium_impact	1.62	medium_impact	0.44	0.8	25.51	12.02	0.39	N	0.90	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10534	10534	A	G	MI.15827	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	65	22	Y	C	tAt/tGt	2.14	0.96	0	probably_damaging	1	neutral	0.17	neutral	1.93	neutral	-2.57	deleterious	-7.66	medium_impact	2.94	0.66	neutral	0.37	neutral	3.37	22.90	deleterious	0.56	0.6	0.66	disease	0.79	disease	0.63	disease	0.76	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	-0.17	medium_impact	1.33	medium_impact	0.15	0.8	25.51	12.02	0.46	N	0.81	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10534	10534	A	T	MI.15828	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	65	22	Y	F	tAt/tTt	2.14	0.96	0	probably_damaging	1	neutral	0.72	neutral	2.01	neutral	-0.25	neutral	-1.87	neutral_impact	0.07	0.84	neutral	0.96	neutral	1.60	13.85	neutral	0.45	0.55	0.2	neutral	0.52	disease	0.35	neutral	0.47	neutral	1	1	deleterious	0.36	neutral	-2	neutral	0.71	deleterious	-3.55	low_impact	0.44	medium_impact	-1.08	low_impact	0.43	0.8	25.51	12.02	0.33	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10534	10534	A	C	MI.15829	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	65	22	Y	S	tAt/tCt	2.14	0.96	0	probably_damaging	1	neutral	0.45	neutral	2.04	neutral	1.17	deleterious	-7.63	low_impact	1.84	0.8	neutral	0.57	neutral	3.52	23.10	deleterious	0.45	0.55	0.25	neutral	0.72	disease	0.44	neutral	0.52	disease	0	1	deleterious	0.23	neutral	-2	neutral	0.73	deleterious	-3.55	low_impact	0.16	medium_impact	0.4	medium_impact	0.49	0.8	25.51	12.02	0.39	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8432	8432	A	G	MI.1583	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	67	23	I	V	Atc/Gtc	-5.89	0	0	benign	0	neutral	0.37	neutral	2.01	neutral	-1.4	neutral	-0.37	low_impact	1.42	1	neutral	0.96	neutral	-0.30	0.65	neutral	0.66698427	0.85	0.13	neutral	0.1	neutral	0.42	neutral	0.05	neutral	9	0.63	neutral	0.69	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	0.16	medium_impact	0.12	medium_impact	0.66	0.85	1.47	7.72	0.45	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10536	10536	C	A	MI.15830	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	67	23	R	S	Cgc/Agc	-2.24	0	0	probably_damaging	0.96	neutral	0.43	neutral	1.63	deleterious	-4.91	deleterious	-5.87	high_impact	3.55	0.53	damaging	0.02	damaging	4.54	24.30	deleterious	0.41	0.5	0.82	disease	0.88	disease	0.73	disease	0.81	disease	6	0.96	neutral	0.24	neutral	2	deleterious	0.88	deleterious	-2.07	low_impact	0.14	medium_impact	1.84	medium_impact	0.40	0.8	54.08	11.58	0.28	N	0.87	disease_causing	0.64	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10536	10536	C	T	MI.15831	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	67	23	R	C	Cgc/Tgc	-2.24	0	0	probably_damaging	0.99	neutral	0.18	neutral	1.49	deleterious	-7.88	deleterious	-7.86	high_impact	4.59	0.51	damaging	0.01	damaging	4.84	24.80	deleterious	0.34	0.5	0.95	disease	0.89	disease	0.78	disease	0.88	disease	8	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-2.63	low_impact	-0.16	medium_impact	2.71	high_impact	0.69	0.85	54.08	11.58	0.47	N	1.00	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10536	10536	C	G	MI.15832	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	67	23	R	G	Cgc/Ggc	-2.24	0	0	probably_damaging	0.97	neutral	0.33	neutral	1.51	deleterious	-5.71	deleterious	-6.87	high_impact	4.04	0.56	damaging	0.05	damaging	4.03	23.60	deleterious	0.37	0.5	0.84	disease	0.86	disease	0.74	disease	0.81	disease	6	0.97	neutral	0.18	neutral	2	deleterious	0.87	deleterious	-2.19	low_impact	0.04	medium_impact	2.25	high_impact	0.36	0.8	54.08	11.58	0.32	N	0.93	disease_causing	0.63	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10537	10537	G	T	MI.15833	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	68	23	R	L	cGc/cTc	4.44	0.99	0	probably_damaging	0.97	neutral	0.69	neutral	1.51	deleterious	-5.31	deleterious	-6.87	high_impact	3.9	0.51	damaging	0.02	damaging	4.16	23.80	deleterious	0.34	0.5	0.84	disease	0.95	disease	0.74	disease	0.84	disease	7	0.97	neutral	0.36	neutral	2	deleterious	0.90	deleterious	-2.19	low_impact	0.4	medium_impact	2.13	high_impact	0.35	0.8	54.08	11.58	0.57	P	0.98	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10537	10537	G	C	MI.15834	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	68	23	R	P	cGc/cCc	4.44	0.99	0	probably_damaging	0.99	neutral	0.2	neutral	1.5	deleterious	-6.24	deleterious	-6.88	high_impact	4.59	0.48	damaging	0.01	damaging	4.04	23.70	deleterious	0.29	0.45	0.89	disease	0.93	disease	0.83	disease	0.88	disease	8	0.99	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-2.63	low_impact	-0.12	medium_impact	2.71	high_impact	0.32	0.8	54.08	11.58	0.67	P	0.97	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10537	10537	G	A	MI.15835	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	68	23	R	H	cGc/cAc	4.44	0.99	0	possibly_damaging	0.46	neutral	0.57	neutral	1.52	deleterious	-5.51	deleterious	-4.9	medium_impact	3.12	0.49	damaging	0.06	damaging	3.80	23.40	deleterious	0.49	0.55	0.88	disease	0.87	disease	0.61	disease	0.7	disease	4	0.43	neutral	0.56	deleterious	0	NA	0.89	deleterious	-0.74	medium_impact	0.28	medium_impact	1.48	medium_impact	0.73	0.85	54.08	11.58	0.54	P	0.83	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10539	10539	T	C	MI.15836	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	70	24	S	P	Tca/Cca	-0.86	0	0	probably_damaging	0.96	neutral	0.22	neutral	1.9	neutral	-1.58	deleterious	-4.76	medium_impact	3.27	0.55	damaging	0.26	damaging	3.83	23.40	deleterious	0.35	0.5	0.55	disease	0.86	disease	0.58	disease	0.78	disease	6	0.97	neutral	0.13	neutral	1	deleterious	0.76	deleterious	-2.07	low_impact	-0.1	medium_impact	1.6	medium_impact	0.62	0.8	55.1	10.39	0.34	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10539	10539	T	G	MI.15837	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	70	24	S	A	Tca/Gca	-0.86	0	0	possibly_damaging	0.69	neutral	0.56	neutral	1.93	neutral	-0.85	deleterious	-2.84	medium_impact	2.02	0.8	neutral	0.76	neutral	2.21	17.57	deleterious	0.64	0.7	0.29	neutral	0.43	neutral	0.4	neutral	0.46	neutral	1	0.64	neutral	0.44	neutral	0	NA	0.42	neutral	-1.12	low_impact	0.27	medium_impact	0.56	medium_impact	0.64	0.8	55.1	10.39	0.3	N	0.42	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10539	10539	T	A	MI.15838	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	70	24	S	T	Tca/Aca	-0.86	0	0	benign	0.15	neutral	0.46	neutral	1.95	neutral	-0.61	deleterious	-2.82	low_impact	1.26	0.73	neutral	0.81	neutral	-0.51	0.21	neutral	0.56	0.6	0.26	neutral	0.08	neutral	0.17	neutral	0.29	neutral	4	0.46	neutral	0.66	deleterious	-6	neutral	0.12	neutral	-0.11	medium_impact	0.17	medium_impact	-0.08	medium_impact	0.81	0.85	55.1	10.39	0.48	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10540	10540	C	T	MI.15839	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	71	24	S	L	tCa/tTa	0.98	0	0	possibly_damaging	0.86	neutral	0.71	neutral	1.89	neutral	-2.08	deleterious	-5.71	medium_impact	2.29	0.79	neutral	0.46	neutral	4.46	24.20	deleterious	0.58	0.65	0.39	neutral	0.74	disease	0.43	neutral	0.55	disease	1	0.84	neutral	0.43	neutral	0	NA	0.55	deleterious	-1.53	low_impact	0.43	medium_impact	0.78	medium_impact	0.79	0.85	55.1	10.39	0.27	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8432	8432	A	T	MI.1584	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	67	23	I	F	Atc/Ttc	-5.89	0	0	benign	0.04	neutral	0.41	neutral	1.71	neutral	-2.91	deleterious	-2.85	medium_impact	2.54	0.99	neutral	0.72	neutral	1.72	14.50	neutral	0.32790408	0.85	0.51	disease	0.28	neutral	0.48	neutral	0.14	neutral	7	0.56	neutral	0.69	deleterious	-3	neutral	0.22	neutral	0.55	medium_impact	0.2	medium_impact	1.08	medium_impact	0.70	0.85	1.47	7.72	0.44	N	0.52	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10540	10540	C	G	MI.15840	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	71	24	S	W	tCa/tGa	0.98	0	0	probably_damaging	1	neutral	0.18	neutral	1.85	deleterious	-5.49	deleterious	-6.64	high_impact	3.61	0.72	neutral	0.36	neutral	4.20	23.90	deleterious	0.33	0.5	0.83	disease	0.84	disease	0.6	disease	0.78	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.79	deleterious	-3.55	low_impact	-0.16	medium_impact	1.89	medium_impact	0.55	0.8	55.1	10.39	0.34	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10542	10542	C	G	MI.15841	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	73	25	H	D	Cac/Gac	-9.85	0	0	probably_damaging	1	neutral	0.2	neutral	1.88	neutral	-0.92	deleterious	-8.81	high_impact	4.66	0.75	neutral	0.04	damaging	3.78	23.40	deleterious	0.37	0.5	0.64	disease	0.86	disease	0.74	disease	0.78	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	-0.12	medium_impact	2.77	high_impact	0.52	0.8	56.12	12.15	0.53	N	0.99	disease_causing	0.78	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10542	10542	C	T	MI.15842	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	73	25	H	Y	Cac/Tac	-9.85	0	0	probably_damaging	1	neutral	1	neutral	1.75	deleterious	-3.58	deleterious	-5.88	medium_impact	3.46	0.71	neutral	0.1	damaging	3.65	23.20	deleterious	0.52	0.6	0.77	disease	0.81	disease	0.69	disease	0.69	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.85	deleterious	-3.55	low_impact	1.88	high_impact	1.76	medium_impact	0.45	0.8	56.12	12.15	0.21	N	0.97	disease_causing	0.57	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10542	10542	C	A	MI.15843	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	73	25	H	N	Cac/Aac	-9.85	0	0	probably_damaging	1	neutral	0.33	neutral	2.02	neutral	0.1	deleterious	-6.86	medium_impact	3.08	0.68	neutral	0.03	damaging	3.85	23.40	deleterious	0.58	0.65	0.69	disease	0.78	disease	0.7	disease	0.74	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	0.04	medium_impact	1.44	medium_impact	0.62	0.8	56.12	12.15	0.28	N	0.98	disease_causing	0.52	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10543	10543	A	C	MI.15844	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	74	25	H	P	cAc/cCc	5.6	1	0	probably_damaging	1	neutral	0.2	neutral	1.76	deleterious	-3.42	deleterious	-9.8	high_impact	3.62	0.63	neutral	0.09	damaging	3.00	22.20	deleterious	0.38	0.5	0.4	neutral	0.89	disease	0.78	disease	0.79	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.55	low_impact	-0.12	medium_impact	1.9	medium_impact	0.35	0.8	56.12	12.15	0.61	P	0.99	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10543	10543	A	T	MI.15845	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	74	25	H	L	cAc/cTc	5.6	1	0	probably_damaging	1	neutral	0.74	neutral	1.76	deleterious	-3.28	deleterious	-10.78	high_impact	4.66	0.68	neutral	0.03	damaging	3.59	23.20	deleterious	0.39	0.5	0.74	disease	0.9	disease	0.72	disease	0.77	disease	5	1	deleterious	0.37	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	0.46	medium_impact	2.77	high_impact	0.37	0.8	56.12	12.15	0.62	P	0.89	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10543	10543	A	G	MI.15846	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	74	25	H	R	cAc/cGc	5.6	1	0	probably_damaging	1	neutral	0.38	neutral	1.81	neutral	-1.93	deleterious	-7.84	high_impact	4.12	0.72	neutral	0.04	damaging	2.77	21.20	deleterious	0.53	0.6	0.66	disease	0.83	disease	0.68	disease	0.72	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.09	medium_impact	2.32	high_impact	0.39	0.8	56.12	12.15	0.65	P	0.98	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	A10543G	LHON	-	+	Reported	1	.	P	P	damaging
chrM	10544	10544	C	G	MI.15847	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	75	25	H	Q	caC/caG	5.6	1	0	probably_damaging	1	neutral	0.3	neutral	1.8	neutral	-2.04	deleterious	-7.83	high_impact	3.98	0.68	neutral	0.05	damaging	3.47	23.00	deleterious	0.55	0.6	0.7	disease	0.81	disease	0.71	disease	0.75	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	0.01	medium_impact	2.2	high_impact	0.70	0.85	56.12	12.15	0.65	P	0.99	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10544	10544	C	A	MI.15848	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	75	25	H	Q	caC/caA	5.6	1	0	probably_damaging	1	neutral	0.3	neutral	1.8	neutral	-2.04	deleterious	-7.83	high_impact	3.98	0.68	neutral	0.05	damaging	3.81	23.40	deleterious	0.55	0.6	0.7	disease	0.81	disease	0.71	disease	0.75	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	0.01	medium_impact	2.2	high_impact	0.70	0.85	56.12	12.15	0.65	P	0.99	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10545	10545	C	G	MI.15849	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	76	26	L	V	Ctc/Gtc	-0.86	0	0	possibly_damaging	0.9	neutral	0.34	neutral	1.58	neutral	-1.42	neutral	-2.28	medium_impact	3.02	0.65	neutral	0.07	damaging	3.26	22.80	deleterious	0.52	0.6	0.46	neutral	0.61	disease	0.68	disease	0.68	disease	4	0.91	neutral	0.22	neutral	0	NA	0.76	deleterious	-1.68	low_impact	0.05	medium_impact	1.39	medium_impact	0.70	0.85	50	10.34	0.32	N	0.74	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8432	8432	A	C	MI.1585	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	67	23	I	L	Atc/Ctc	-5.89	0	0	benign	0	neutral	1	neutral	1.92	neutral	0.93	neutral	-0.79	neutral_impact	0.7	1	neutral	0.95	neutral	0.23	4.94	deleterious	0.44253433	0.85	0.11	neutral	0.12	neutral	0.33	neutral	0.06	neutral	9	0	neutral	1	deleterious	-6	neutral	0.15	neutral	2.09	high_impact	1.98	high_impact	-0.5	medium_impact	0.64	0.85	1.47	7.72	0.39	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10545	10545	C	A	MI.15850	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	76	26	L	I	Ctc/Atc	-0.86	0	0	possibly_damaging	0.9	neutral	0.32	neutral	1.65	neutral	-1.09	neutral	-1.48	medium_impact	2.27	0.8	neutral	0.36	neutral	4.08	23.70	deleterious	0.38	0.5	0.31	neutral	0.63	disease	0.55	disease	0.58	disease	1	0.91	neutral	0.21	neutral	0	NA	0.73	deleterious	-1.68	low_impact	0.03	medium_impact	0.77	medium_impact	0.69	0.85	50	10.34	0.35	N	0.54	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10545	10545	C	T	MI.15851	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	76	26	L	F	Ctc/Ttc	-0.86	0	0	possibly_damaging	0.5	neutral	0.52	neutral	1.52	deleterious	-3.48	deleterious	-2.95	medium_impact	2.08	0.82	neutral	0.43	neutral	3.70	23.30	deleterious	0.46	0.55	0.62	disease	0.44	neutral	0.44	neutral	0.56	disease	1	0.49	neutral	0.51	deleterious	0	NA	0.77	deleterious	-0.8	medium_impact	0.23	medium_impact	0.61	medium_impact	0.61	0.8	50	10.34	0.28	N	0.85	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10546	10546	T	C	MI.15852	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	77	26	L	P	cTc/cCc	-0.86	0	0	probably_damaging	1	neutral	0.13	neutral	1.47	deleterious	-5.87	deleterious	-6.08	high_impact	4.54	0.51	damaging	0.06	damaging	3.76	23.30	deleterious	0.16	0.45	0.91	disease	0.86	disease	0.78	disease	0.87	disease	7	1	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.25	medium_impact	2.67	high_impact	0.54	0.8	50	10.34	0.5	N	0.96	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10546	10546	T	G	MI.15853	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	77	26	L	R	cTc/cGc	-0.86	0	0	probably_damaging	0.99	neutral	0.29	neutral	1.48	deleterious	-5.36	deleterious	-5.14	high_impact	4.54	0.57	damaging	0.04	damaging	4.05	23.70	deleterious	0.08	0.35	0.89	disease	0.87	disease	0.77	disease	0.86	disease	7	0.99	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-2.63	low_impact	-0.01	medium_impact	2.67	high_impact	0.42	0.8	50	10.34	0.52	N	0.97	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10546	10546	T	A	MI.15854	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	77	26	L	H	cTc/cAc	-0.86	0	0	probably_damaging	1	neutral	0.43	neutral	1.47	deleterious	-6.03	deleterious	-5.91	high_impact	4.54	0.65	neutral	0.05	damaging	3.99	23.60	deleterious	0.12	0.4	0.93	disease	0.84	disease	0.75	disease	0.85	disease	7	0.99	deleterious	0.22	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.14	medium_impact	2.67	high_impact	0.52	0.8	50	10.34	0.45	N	0.98	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10548	10548	A	G	MI.15855	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	79	27	M	V	Ata/Gta	-4.09	0	0	benign	0.02	neutral	0.32	neutral	1.94	neutral	1.72	deleterious	-3.67	medium_impact	2.17	0.82	neutral	0.64	neutral	-0.36	0.47	neutral	0.49	0.55	0.35	neutral	0.55	disease	0.4	neutral	0.49	neutral	0	0.67	neutral	0.65	deleterious	-3	neutral	0.17	neutral	0.75	medium_impact	0.03	medium_impact	0.68	medium_impact	0.59	0.8	54.08	11.45	0.37	N	0.06	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10548	10548	A	C	MI.15856	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	79	27	M	L	Ata/Cta	-4.09	0	0	benign	0.06	neutral	1	neutral	2.27	neutral	1.87	deleterious	-2.83	neutral_impact	0.36	0.72	neutral	0.7	neutral	-0.87	0.03	neutral	0.41	0.5	0.11	neutral	0.28	neutral	0.32	neutral	0.43	neutral	1	0.06	neutral	0.97	deleterious	-6	neutral	0.12	neutral	0.29	medium_impact	1.88	high_impact	-0.84	medium_impact	0.59	0.8	54.08	11.45	0.33	N	0.15	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10548	10548	A	T	MI.15857	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	79	27	M	L	Ata/Tta	-4.09	0	0	benign	0.06	neutral	1	neutral	2.27	neutral	1.87	deleterious	-2.83	neutral_impact	0.36	0.72	neutral	0.7	neutral	-0.77	0.05	neutral	0.41	0.5	0.11	neutral	0.28	neutral	0.32	neutral	0.43	neutral	1	0.06	neutral	0.97	deleterious	-6	neutral	0.12	neutral	0.29	medium_impact	1.88	high_impact	-0.84	medium_impact	0.59	0.8	54.08	11.45	0.33	N	0.15	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10549	10549	T	A	MI.15858	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	80	27	M	K	aTa/aAa	1.21	0.55	0	possibly_damaging	0.78	neutral	0.24	neutral	1.76	deleterious	-3.17	deleterious	-5.78	high_impact	3.77	0.73	neutral	0.32	neutral	3.59	23.20	deleterious	0.14	0.4	0.81	disease	0.8	disease	0.69	disease	0.79	disease	6	0.85	neutral	0.23	neutral	1	deleterious	0.67	deleterious	-1.31	low_impact	-0.07	medium_impact	2.02	high_impact	0.31	0.8	54.08	11.45	0.39	N	0.84	polymorphism	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10549	10549	T	C	MI.15859	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	80	27	M	T	aTa/aCa	1.21	0.55	0	possibly_damaging	0.44	neutral	0.19	neutral	1.81	neutral	-1.7	deleterious	-5.69	high_impact	3.77	0.76	neutral	0.45	neutral	1.18	11.65	neutral	0.35	0.5	0.65	disease	0.6	disease	0.63	disease	0.73	disease	5	0.78	neutral	0.38	neutral	1	deleterious	0.46	deleterious	-0.71	medium_impact	-0.14	medium_impact	2.02	high_impact	0.28	0.8	54.08	11.45	0.32	N	0.57	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8433	8433	T	G	MI.1586	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	68	23	I	S	aTc/aGc	-2.42	0	0.01	benign	0.05	neutral	0.08	neutral	1.64	deleterious	-4.31	deleterious	-4.33	medium_impact	3.35	0.99	neutral	0.43	neutral	2.25	17.82	deleterious	0.25608775	0.85	0.64	disease	0.45	neutral	0.61	disease	0.29	neutral	4	0.91	neutral	0.52	deleterious	-3	neutral	0.27	neutral	0.46	medium_impact	-0.31	medium_impact	1.77	medium_impact	0.62	0.85	1.47	7.72	0.51	N	0.72	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10550	10550	A	T	MI.15860	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	81	27	M	I	atA/atT	7.44	0.98	0.06	benign	0.02	neutral	0.34	neutral	2.02	neutral	1.74	deleterious	-3.7	low_impact	1.48	0.8	neutral	0.8	neutral	-0.09	1.81	neutral	0.47	0.55	0.23	neutral	0.46	neutral	0.34	neutral	0.46	neutral	1	0.64	neutral	0.66	deleterious	-6	neutral	0.15	neutral	0.75	medium_impact	0.05	medium_impact	0.1	medium_impact	0.65	0.8	54.08	11.45	0.6	P	0.19	polymorphism	0.99	0.09	rs28358280	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10550	10550	A	C	MI.15861	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	81	27	M	I	atA/atC	7.44	0.98	0.06	benign	0.02	neutral	0.34	neutral	2.02	neutral	1.74	deleterious	-3.7	low_impact	1.48	0.8	neutral	0.8	neutral	-0.19	1.16	neutral	0.47	0.55	0.23	neutral	0.46	neutral	0.34	neutral	0.46	neutral	1	0.64	neutral	0.66	deleterious	-6	neutral	0.15	neutral	0.75	medium_impact	0.05	medium_impact	0.1	medium_impact	0.65	0.8	54.08	11.45	0.59	P	0.19	polymorphism	0.99	0.09	rs28358280	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10551	10551	T	A	MI.15862	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	82	28	S	T	Tcc/Acc	-1.09	0.02	0	possibly_damaging	0.74	neutral	0.15	neutral	1.85	neutral	-1.78	deleterious	-2.87	medium_impact	2.9	0.72	neutral	0.52	neutral	1.71	14.47	neutral	0.48	0.55	0.56	disease	0.72	disease	0.51	disease	0.53	disease	1	0.89	neutral	0.21	neutral	0	NA	0.70	deleterious	-1.22	low_impact	-0.21	medium_impact	1.29	medium_impact	0.76	0.85	48.98	10.12	0.4	N	0.48	disease_causing	0.94	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10551	10551	T	C	MI.15863	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	82	28	S	P	Tcc/Ccc	-1.09	0.02	0	probably_damaging	0.96	neutral	0.07	neutral	1.8	deleterious	-3.58	deleterious	-4.82	high_impact	3.79	0.63	neutral	0.46	neutral	3.75	23.30	deleterious	0.16	0.45	0.74	disease	0.87	disease	0.73	disease	0.79	disease	6	0.99	deleterious	0.06	neutral	2	deleterious	0.83	deleterious	-2.07	low_impact	-0.41	medium_impact	2.04	high_impact	0.73	0.85	48.98	10.12	0.42	N	0.83	disease_causing	0.99	0.18	.	.	.	.	.	endometrium tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10551	10551	T	G	MI.15864	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	82	28	S	A	Tcc/Gcc	-1.09	0.02	0	benign	0.08	neutral	0.18	neutral	1.85	neutral	-1.69	deleterious	-2.72	medium_impact	2.55	0.83	neutral	0.68	neutral	1.58	13.75	neutral	0.4	0.5	0.46	neutral	0.68	disease	0.38	neutral	0.5	disease	0	0.8	neutral	0.55	deleterious	-3	neutral	0.26	neutral	0.17	medium_impact	-0.16	medium_impact	1	medium_impact	0.75	0.85	48.98	10.12	0.43	N	0.01	disease_causing	0.84	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10552	10552	C	T	MI.15865	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	83	28	S	F	tCc/tTc	5.83	1	0	probably_damaging	0.98	neutral	0.22	neutral	1.8	deleterious	-3.6	deleterious	-5.79	high_impact	3.99	0.64	neutral	0.35	neutral	4.00	23.60	deleterious	0.21	0.45	0.85	disease	0.85	disease	0.64	disease	0.78	disease	6	0.98	deleterious	0.12	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	-0.1	medium_impact	2.21	high_impact	0.52	0.8	48.98	10.12	0.66	P	0.96	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10552	10552	C	G	MI.15866	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	83	28	S	C	tCc/tGc	5.83	1	0	probably_damaging	0.98	neutral	0.09	neutral	1.79	deleterious	-4.25	deleterious	-4.79	high_impact	3.54	0.73	neutral	0.35	neutral	3.38	22.90	deleterious	0.23	0.45	0.84	disease	0.8	disease	0.6	disease	0.74	disease	5	0.99	deleterious	0.06	neutral	2	deleterious	0.80	deleterious	-2.35	low_impact	-0.35	medium_impact	1.83	medium_impact	0.77	0.85	48.98	10.12	0.64	P	0.56	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10552	10552	C	A	MI.15867	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	83	28	S	Y	tCc/tAc	5.83	1	0	probably_damaging	0.98	neutral	0.31	neutral	1.79	deleterious	-3.9	deleterious	-5.79	high_impact	3.64	0.71	neutral	0.53	neutral	4.02	23.60	deleterious	0.18	0.45	0.85	disease	0.87	disease	0.56	disease	0.76	disease	5	0.99	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	0.02	medium_impact	1.91	medium_impact	0.68	0.85	48.98	10.12	0.65	P	0.97	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10554	10554	T	A	MI.15868	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	85	29	S	T	Tcc/Acc	-20	0	0	probably_damaging	1	neutral	0.23	neutral	2.04	neutral	0.6	neutral	-1.4	neutral_impact	-0.24	0.83	neutral	0.99	neutral	2.13	17.04	deleterious	0.38	0.5	0.16	neutral	0.23	neutral	0.28	neutral	0.42	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.67	deleterious	-3.55	low_impact	-0.08	medium_impact	-1.34	low_impact	0.73	0.85	26.53	15.35	0.37	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10554	10554	T	C	MI.15869	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	85	29	S	P	Tcc/Ccc	-20	0	0	probably_damaging	1	neutral	0.06	neutral	1.94	neutral	-2.5	deleterious	-4.13	medium_impact	3.29	0.56	damaging	0.37	neutral	3.85	23.40	deleterious	0.17	0.45	0.48	neutral	0.86	disease	0.65	disease	0.8	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.55	low_impact	-0.45	medium_impact	1.62	medium_impact	0.73	0.85	26.53	15.35	0.37	N	0.81	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8433	8433	T	A	MI.1587	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	68	23	I	N	aTc/aAc	-2.42	0	0.01	benign	0.23	deleterious	0.04	neutral	1.63	deleterious	-5.36	deleterious	-5.33	medium_impact	3.35	1	neutral	0.46	neutral	2.50	19.48	deleterious	0.23666041	0.85	0.78	disease	0.48	neutral	0.65	disease	0.41	neutral	2	0.95	neutral	0.41	neutral	1	deleterious	0.43	neutral	-0.26	medium_impact	-0.49	medium_impact	1.77	medium_impact	0.66	0.85	1.47	7.72	0.49	N	0.82	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10554	10554	T	G	MI.15870	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	85	29	S	A	Tcc/Gcc	-20	0	0	probably_damaging	1	neutral	0.59	neutral	2.07	neutral	0.91	neutral	-2.14	neutral_impact	0.53	0.75	neutral	0.95	neutral	0.88	9.96	deleterious	0.46	0.55	0.12	neutral	0.15	neutral	0.25	neutral	0.24	neutral	5	1	deleterious	0.3	neutral	-2	neutral	0.65	deleterious	-3.55	low_impact	0.3	medium_impact	-0.69	medium_impact	0.71	0.85	26.53	15.35	0.32	N	0.30	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10555	10555	C	T	MI.15871	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	86	29	S	F	tCc/tTc	0.52	0.3	0	probably_damaging	1	neutral	0.22	neutral	1.97	neutral	-0.78	deleterious	-5.1	medium_impact	2.59	0.57	damaging	0.46	neutral	4.14	23.80	deleterious	0.29	0.45	0.34	neutral	0.7	disease	0.56	disease	0.71	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-3.55	low_impact	-0.1	medium_impact	1.03	medium_impact	0.50	0.8	26.53	15.35	0.38	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10555	10555	C	G	MI.15872	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	86	29	S	C	tCc/tGc	0.52	0.3	0	probably_damaging	1	neutral	0.16	neutral	1.94	neutral	-2.4	deleterious	-4.07	medium_impact	2.04	0.62	neutral	0.38	neutral	3.49	23.10	deleterious	0.21	0.45	0.52	disease	0.63	disease	0.52	disease	0.61	disease	2	1	deleterious	0.08	neutral	1	deleterious	0.72	deleterious	-3.55	low_impact	-0.19	medium_impact	0.57	medium_impact	0.71	0.85	26.53	15.35	0.33	N	0.52	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10555	10555	C	A	MI.15873	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	86	29	S	Y	tCc/tAc	0.52	0.3	0	probably_damaging	1	neutral	0.24	neutral	1.95	neutral	-1.57	deleterious	-5.1	medium_impact	2.94	0.68	neutral	0.46	neutral	3.94	23.50	deleterious	0.25	0.45	0.4	neutral	0.69	disease	0.55	disease	0.7	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	-0.07	medium_impact	1.33	medium_impact	0.69	0.85	26.53	15.35	0.38	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10557	10557	C	G	MI.15874	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	88	30	L	V	Cta/Gta	-9.85	0	0	probably_damaging	1	neutral	0.19	neutral	1.05	deleterious	-3.41	deleterious	-2.94	high_impact	4.76	0.52	damaging	0.1	damaging	3.31	22.90	deleterious	0.25	0.45	0.62	disease	0.63	disease	0.73	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-3.55	low_impact	-0.14	medium_impact	2.85	high_impact	0.75	0.85	55.1	12.02	0.65	P	0.75	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10557	10557	C	A	MI.15875	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	88	30	L	M	Cta/Ata	-9.85	0	0	probably_damaging	1	neutral	0.29	neutral	0.95	deleterious	-5.28	neutral	-1.96	high_impact	3.87	0.59	damaging	0.1	damaging	3.65	23.20	deleterious	0.22	0.45	0.69	disease	0.63	disease	0.71	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.78	deleterious	-3.55	low_impact	-0.01	medium_impact	2.11	high_impact	0.57	0.8	55.1	12.02	0.32	N	0.77	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10558	10558	T	A	MI.15876	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	89	30	L	Q	cTa/cAa	0.06	0	0	probably_damaging	1	deleterious	0.02	neutral	0.91	deleterious	-8.42	deleterious	-5.88	high_impact	4.76	0.44	damaging	0.07	damaging	3.92	23.50	deleterious	0.13	0.4	0.9	disease	0.84	disease	0.73	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.55	low_impact	-0.73	medium_impact	2.85	high_impact	0.54	0.8	55.1	12.02	0.55	P	0.99	polymorphism	0.98	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10558	10558	T	G	MI.15877	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	89	30	L	R	cTa/cGa	0.06	0	0	probably_damaging	1	neutral	0.06	neutral	0.91	deleterious	-8.57	deleterious	-5.89	high_impact	4.76	0.46	damaging	0.06	damaging	4.07	23.70	deleterious	0.12	0.4	0.89	disease	0.87	disease	0.8	disease	0.88	disease	8	1	deleterious	0.03	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.45	medium_impact	2.85	high_impact	0.39	0.8	55.1	12.02	0.57	P	0.99	polymorphism	0.98	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10558	10558	T	C	MI.15878	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	89	30	L	P	cTa/cCa	0.06	0	0	probably_damaging	1	deleterious	0.01	neutral	0.91	deleterious	-8.84	deleterious	-6.88	high_impact	4.76	0.38	damaging	0.07	damaging	3.76	23.40	deleterious	0.15	0.4	0.92	disease	0.84	disease	0.8	disease	0.89	disease	8	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.55	low_impact	-0.9	medium_impact	2.85	high_impact	0.42	0.8	55.1	12.02	0.62	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10560	10560	C	A	MI.15879	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	91	31	L	M	Cta/Ata	-5.93	0	0	probably_damaging	1	neutral	0.21	neutral	1.5	neutral	-2.2	neutral	-1.88	medium_impact	3	0.76	neutral	0.2	damaging	3.60	23.20	deleterious	0.27	0.45	0.56	disease	0.5	disease	0.47	neutral	0.51	disease	0	1	deleterious	0.11	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	-0.11	medium_impact	1.38	medium_impact	0.55	0.8	52.04	11.96	0.35	N	0.77	polymorphism	0.8	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8433	8433	T	C	MI.1588	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	68	23	I	T	aTc/aCc	-2.42	0	0.01	benign	0.02	deleterious	0.03	neutral	1.68	deleterious	-3.6	deleterious	-3.16	medium_impact	2.19	1	neutral	0.86	neutral	0.23	5.04	deleterious	0.46889253	0.85	0.45	neutral	0.32	neutral	0.5	neutral	0.18	neutral	6	0.97	neutral	0.51	deleterious	1	deleterious	0.22	neutral	0.85	medium_impact	-0.56	medium_impact	0.78	medium_impact	0.68	0.85	1.47	7.72	0.54	P	0.61	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10560	10560	C	G	MI.15880	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	91	31	L	V	Cta/Gta	-5.93	0	0	probably_damaging	1	neutral	0.18	neutral	1.43	neutral	-2.88	deleterious	-2.91	medium_impact	3.41	0.66	neutral	0.06	damaging	3.30	22.80	deleterious	0.25	0.45	0.44	neutral	0.52	disease	0.66	disease	0.67	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.73	deleterious	-3.55	low_impact	-0.16	medium_impact	1.72	medium_impact	0.54	0.8	52.04	11.96	0.34	N	0.75	polymorphism	0.76	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10561	10561	T	A	MI.15881	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	92	31	L	Q	cTa/cAa	-0.17	0	0	probably_damaging	1	neutral	0.06	neutral	1.33	deleterious	-6.93	deleterious	-5.82	high_impact	4.65	0.64	neutral	0.05	damaging	4.12	23.80	deleterious	0.17	0.45	0.88	disease	0.79	disease	0.66	disease	0.78	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	-0.45	medium_impact	2.76	high_impact	0.51	0.8	52.04	11.96	0.45	N	0.99	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10561	10561	T	G	MI.15882	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	92	31	L	R	cTa/cGa	-0.17	0	0	probably_damaging	1	neutral	0.07	neutral	1.33	deleterious	-6.93	deleterious	-5.84	high_impact	4.65	0.61	neutral	0.04	damaging	4.02	23.60	deleterious	0.15	0.4	0.88	disease	0.82	disease	0.75	disease	0.83	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.41	medium_impact	2.76	high_impact	0.37	0.8	52.04	11.96	0.5	N	0.99	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10561	10561	T	C	MI.15883	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	92	31	L	P	cTa/cCa	-0.17	0	0	probably_damaging	1	deleterious	0.04	neutral	1.32	deleterious	-7.34	deleterious	-6.83	high_impact	4.65	0.54	damaging	0.05	damaging	3.86	23.50	deleterious	0.18	0.45	0.91	disease	0.8	disease	0.75	disease	0.83	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-3.55	low_impact	-0.56	medium_impact	2.76	high_impact	0.48	0.8	52.04	11.96	0.43	N	1.00	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10563	10563	T	C	MI.15884	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	94	32	C	R	Tgc/Cgc	-1.09	0.01	0	probably_damaging	1	neutral	0.14	neutral	1.74	deleterious	-4.77	deleterious	-11.74	high_impact	3.96	0.65	neutral	0.07	damaging	3.34	22.90	deleterious	0.25	0.45	0.78	disease	0.91	disease	0.74	disease	0.8	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.23	medium_impact	2.18	high_impact	0.36	0.8	54.08	12.3	0.42	N	1.00	disease_causing_automatic	1	0.20	rs267606892	Pathogenic	Familial_colorectal_cancer	24745	MedGen:CN029768	colorectal tumor	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	10563	10563	T	A	MI.15885	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	94	32	C	S	Tgc/Agc	-1.09	0.01	0	probably_damaging	1	neutral	0.3	neutral	2.05	neutral	-0.3	deleterious	-9.77	low_impact	1.12	0.69	neutral	0.17	damaging	3.37	22.90	deleterious	0.38	0.5	0.19	neutral	0.82	disease	0.49	neutral	0.7	disease	4	1	deleterious	0.15	neutral	-2	neutral	0.75	deleterious	-3.55	low_impact	0.01	medium_impact	-0.2	medium_impact	0.70	0.85	54.08	12.3	0.32	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10563	10563	T	G	MI.15886	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	94	32	C	G	Tgc/Ggc	-1.09	0.01	0	probably_damaging	1	neutral	0.19	neutral	2.1	deleterious	-3.37	deleterious	-11.74	medium_impact	3.15	0.64	neutral	0.1	damaging	3.16	22.60	deleterious	0.31	0.5	0.55	disease	0.86	disease	0.64	disease	0.69	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	-0.14	medium_impact	1.5	medium_impact	0.62	0.8	54.08	12.3	0.36	N	1.00	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10564	10564	G	T	MI.15887	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	95	32	C	F	tGc/tTc	4.44	1	0	probably_damaging	1	neutral	0.44	neutral	1.73	deleterious	-5.29	deleterious	-10.76	high_impact	3.75	0.63	neutral	0.06	damaging	3.76	23.30	deleterious	0.28	0.45	0.82	disease	0.89	disease	0.66	disease	0.76	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0.15	medium_impact	2.01	high_impact	0.54	0.8	54.08	12.3	0.52	N	0.99	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10564	10564	G	C	MI.15888	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	95	32	C	S	tGc/tCc	4.44	1	0	probably_damaging	1	neutral	0.3	neutral	2.05	neutral	-0.3	deleterious	-9.77	low_impact	1.12	0.69	neutral	0.17	damaging	3.05	22.40	deleterious	0.38	0.5	0.19	neutral	0.82	disease	0.49	neutral	0.7	disease	4	1	deleterious	0.15	neutral	-2	neutral	0.75	deleterious	-3.55	low_impact	0.01	medium_impact	-0.2	medium_impact	0.70	0.85	54.08	12.3	0.41	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10564	10564	G	A	MI.15889	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	95	32	C	Y	tGc/tAc	4.44	1	0	probably_damaging	1	neutral	0.48	neutral	1.73	deleterious	-5.68	deleterious	-10.76	high_impact	3.96	0.71	neutral	0.08	damaging	3.59	23.20	deleterious	0.28	0.45	0.86	disease	0.89	disease	0.68	disease	0.79	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.19	medium_impact	2.18	high_impact	0.51	0.8	54.08	12.3	0.55	N	0.99	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8434	8434	C	A	MI.1589	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	69	23	I	M	atC/atA	5.68	0.87	0.01	benign	0.08	neutral	0.17	neutral	1.68	neutral	-1.72	neutral	-1.05	low_impact	1.73	0.98	neutral	0.88	neutral	0.59	8.09	deleterious	0.43104827	0.85	0.47	neutral	0.17	neutral	0.43	neutral	0.06	neutral	9	0.81	neutral	0.55	deleterious	-6	neutral	0.24	neutral	0.25	medium_impact	-0.1	medium_impact	0.39	medium_impact	0.76	0.85	1.47	7.72	0.57	P	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10565	10565	C	A	MI.15890	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	96	32	C	W	tgC/tgA	6.06	1	0	probably_damaging	1	neutral	0.08	neutral	1.72	deleterious	-7.35	deleterious	-10.77	high_impact	4.3	0.71	neutral	0.07	damaging	4.53	24.30	deleterious	0.22	0.45	0.94	disease	0.91	disease	0.73	disease	0.82	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.38	medium_impact	2.47	high_impact	0.42	0.8	54.08	12.3	0.58	P	0.99	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10565	10565	C	G	MI.15891	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	96	32	C	W	tgC/tgG	6.06	1	0	probably_damaging	1	neutral	0.08	neutral	1.72	deleterious	-7.35	deleterious	-10.77	high_impact	4.3	0.71	neutral	0.07	damaging	4.21	23.90	deleterious	0.22	0.45	0.94	disease	0.91	disease	0.73	disease	0.82	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.38	medium_impact	2.47	high_impact	0.42	0.8	54.08	12.3	0.58	P	0.99	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10566	10566	C	G	MI.15892	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	97	33	L	V	Cta/Gta	-2.71	0	0	probably_damaging	1	neutral	0.13	neutral	1.52	neutral	-1.1	deleterious	-2.92	high_impact	3.62	0.78	neutral	0.19	damaging	3.33	22.90	deleterious	0.34	0.5	0.62	disease	0.46	neutral	0.62	disease	0.58	disease	2	1	deleterious	0.07	neutral	2	deleterious	0.75	deleterious	-3.55	low_impact	-0.25	medium_impact	1.9	medium_impact	0.62	0.8	54.08	11.68	0.36	N	0.75	disease_causing	0.9	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10566	10566	C	A	MI.15893	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	97	33	L	M	Cta/Ata	-2.71	0	0	probably_damaging	1	neutral	0.21	neutral	1.49	deleterious	-3.81	neutral	-1.93	medium_impact	3.22	0.75	neutral	0.2	damaging	3.60	23.20	deleterious	0.29	0.45	0.69	disease	0.45	neutral	0.6	disease	0.6	disease	2	1	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	-0.11	medium_impact	1.56	medium_impact	0.60	0.8	54.08	11.68	0.37	N	0.77	disease_causing	0.88	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10567	10567	T	C	MI.15894	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	98	33	L	P	cTa/cCa	-1.32	0	0	probably_damaging	1	deleterious	0.01	neutral	1.41	deleterious	-6.48	deleterious	-6.86	high_impact	4.66	0.57	damaging	0.04	damaging	3.80	23.40	deleterious	0.21	0.45	0.92	disease	0.79	disease	0.76	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.55	low_impact	-0.9	medium_impact	2.77	high_impact	0.48	0.8	54.08	11.68	0.44	N	1.00	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10567	10567	T	G	MI.15895	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	98	33	L	R	cTa/cGa	-1.32	0	0	probably_damaging	1	deleterious	0.02	neutral	1.42	deleterious	-6.08	deleterious	-5.87	high_impact	4.66	0.62	neutral	0.04	damaging	4.07	23.70	deleterious	0.17	0.45	0.89	disease	0.82	disease	0.76	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.55	low_impact	-0.73	medium_impact	2.77	high_impact	0.43	0.8	54.08	11.68	0.49	N	0.99	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10567	10567	T	A	MI.15896	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	98	33	L	Q	cTa/cAa	-1.32	0	0	probably_damaging	1	neutral	0.05	neutral	1.41	deleterious	-6.1	deleterious	-5.86	high_impact	4.66	0.64	neutral	0.05	damaging	3.96	23.60	deleterious	0.18	0.45	0.9	disease	0.75	disease	0.67	disease	0.78	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	-0.5	medium_impact	2.77	high_impact	0.57	0.8	54.08	11.68	0.45	N	0.99	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10569	10569	G	A	MI.15897	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	100	34	E	K	Gaa/Aaa	0.06	0.92	0	benign	0.29	neutral	0.29	neutral	1.54	deleterious	-5.94	deleterious	-3.92	high_impact	4.78	0.42	damaging	0.26	damaging	2.62	20.30	deleterious	0.33	0.5	0.75	disease	0.86	disease	0.84	disease	0.82	disease	6	0.65	neutral	0.5	deleterious	-2	neutral	0.43	neutral	-0.45	medium_impact	-0.01	medium_impact	2.87	high_impact	0.54	0.8	55.1	12.25	0.74	P	1.00	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10569	10569	G	C	MI.15898	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	100	34	E	Q	Gaa/Caa	0.06	0.92	0	probably_damaging	0.91	neutral	0.29	neutral	1.51	deleterious	-6.32	deleterious	-2.94	high_impact	4.78	0.41	damaging	0.39	neutral	3.15	22.60	deleterious	0.39	0.5	0.79	disease	0.74	disease	0.78	disease	0.8	disease	6	0.93	neutral	0.19	neutral	2	deleterious	0.79	deleterious	-1.72	low_impact	-0.01	medium_impact	2.87	high_impact	0.68	0.85	55.1	12.25	0.79	P	0.84	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10570	10570	A	G	MI.15899	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	101	34	E	G	gAa/gGa	9.05	1	0	probably_damaging	0.96	neutral	0.33	neutral	1.57	deleterious	-6.43	deleterious	-6.85	high_impact	4.42	0.46	damaging	0.51	neutral	4.04	23.70	deleterious	0.3	0.45	0.78	disease	0.73	disease	0.76	disease	0.75	disease	5	0.96	neutral	0.19	neutral	2	deleterious	0.83	deleterious	-2.07	low_impact	0.04	medium_impact	2.57	high_impact	0.31	0.8	55.1	12.25	0.67	P	0.73	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8600	8600	T	G	MI.159	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	74	25	L	R	cTa/cGa	-2.19	0	0	probably_damaging	1	deleterious	0.03	neutral	4.13	deleterious	-3.51	deleterious	-3.3	medium_impact	3	0.8	neutral	0.45	neutral	3.90	23.50	deleterious	0.18	0.65	0.58	disease	0.69	disease	0.69	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.6	low_impact	-0.56	medium_impact	1.47	medium_impact	0.52	0.9	10.18	13.06	0.32	N	0.85	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8434	8434	C	G	MI.1590	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	69	23	I	M	atC/atG	5.68	0.87	0.01	benign	0.08	neutral	0.17	neutral	1.68	neutral	-1.72	neutral	-1.05	low_impact	1.73	0.98	neutral	0.88	neutral	0.15	4.10	deleterious	0.43104827	0.85	0.47	neutral	0.17	neutral	0.43	neutral	0.06	neutral	9	0.81	neutral	0.55	deleterious	-6	neutral	0.24	neutral	0.25	medium_impact	-0.1	medium_impact	0.39	medium_impact	0.76	0.85	1.47	7.72	0.57	P	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10570	10570	A	C	MI.15900	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	101	34	E	A	gAa/gCa	9.05	1	0	probably_damaging	0.91	neutral	0.51	neutral	1.54	deleterious	-6.2	deleterious	-5.86	high_impact	4.78	0.51	damaging	0.4	neutral	3.43	23.00	deleterious	0.23	0.45	0.78	disease	0.68	disease	0.75	disease	0.77	disease	5	0.9	neutral	0.3	neutral	2	deleterious	0.78	deleterious	-1.72	low_impact	0.22	medium_impact	2.87	high_impact	0.43	0.8	55.1	12.25	0.68	P	0.84	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10570	10570	A	T	MI.15901	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	101	34	E	V	gAa/gTa	9.05	1	0	probably_damaging	0.98	neutral	0.5	neutral	1.49	deleterious	-7.36	deleterious	-6.86	high_impact	4.78	0.43	damaging	0.29	neutral	3.94	23.60	deleterious	0.24	0.45	0.88	disease	0.83	disease	0.78	disease	0.85	disease	7	0.98	neutral	0.26	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	0.21	medium_impact	2.87	high_impact	0.46	0.8	55.1	12.25	0.78	P	0.89	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10571	10571	A	T	MI.15902	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	102	34	E	D	gaA/gaT	6.75	1	0	possibly_damaging	0.89	neutral	0.2	neutral	1.53	deleterious	-5.15	deleterious	-2.94	high_impact	4.78	0.48	damaging	0.38	neutral	3.69	23.30	deleterious	0.41	0.5	0.63	disease	0.73	disease	0.79	disease	0.77	disease	5	0.93	neutral	0.16	neutral	1	deleterious	0.76	deleterious	-1.64	low_impact	-0.12	medium_impact	2.87	high_impact	0.70	0.85	55.1	12.25	0.79	P	0.83	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10571	10571	A	C	MI.15903	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	102	34	E	D	gaA/gaC	6.75	1	0	possibly_damaging	0.89	neutral	0.2	neutral	1.53	deleterious	-5.15	deleterious	-2.94	high_impact	4.78	0.48	damaging	0.38	neutral	3.56	23.10	deleterious	0.41	0.5	0.63	disease	0.73	disease	0.79	disease	0.77	disease	5	0.93	neutral	0.16	neutral	1	deleterious	0.76	deleterious	-1.64	low_impact	-0.12	medium_impact	2.87	high_impact	0.70	0.85	55.1	12.25	0.79	P	0.83	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10572	10572	G	C	MI.15904	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	103	35	G	R	Gga/Cga	0.06	0.81	0	probably_damaging	1	neutral	0.34	neutral	1.86	deleterious	-3.04	deleterious	-7.61	high_impact	4.04	0.67	neutral	0.16	damaging	3.86	23.40	deleterious	0.21	0.45	0.47	neutral	0.86	disease	0.67	disease	0.75	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.55	low_impact	0.05	medium_impact	2.25	high_impact	0.64	0.8	54.08	11.89	0.41	N	0.99	disease_causing	0.93	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10572	10572	G	T	MI.15905	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	103	35	G	W	Gga/Tga	0.06	0.81	0	probably_damaging	1	neutral	0.18	neutral	1.85	deleterious	-4.3	deleterious	-7.69	high_impact	4.04	0.71	neutral	0.17	damaging	4.31	24.00	deleterious	0.27	0.45	0.72	disease	0.85	disease	0.64	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.78	deleterious	-3.55	low_impact	-0.16	medium_impact	2.25	high_impact	0.40	0.8	54.08	11.89	0.42	N	0.99	disease_causing	0.96	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10573	10573	G	A	MI.15906	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	104	35	G	E	gGa/gAa	2.83	1	0	probably_damaging	1	neutral	0.34	neutral	1.86	deleterious	-3.33	deleterious	-7.57	high_impact	4.04	0.72	neutral	0.24	damaging	3.80	23.40	deleterious	0.33	0.5	0.41	neutral	0.81	disease	0.65	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-3.55	low_impact	0.05	medium_impact	2.25	high_impact	0.55	0.8	54.08	11.89	0.52	N	0.99	disease_causing	0.94	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10573	10573	G	C	MI.15907	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	104	35	G	A	gGa/gCa	2.83	1	0	probably_damaging	1	neutral	0.54	neutral	1.93	neutral	-0.95	deleterious	-5.63	low_impact	1.67	0.75	neutral	0.57	neutral	2.92	21.90	deleterious	0.52	0.6	0.32	neutral	0.47	neutral	0.37	neutral	0.42	neutral	2	1	deleterious	0.27	neutral	-2	neutral	0.70	deleterious	-3.55	low_impact	0.25	medium_impact	0.26	medium_impact	0.69	0.85	54.08	11.89	0.42	N	0.98	disease_causing	0.86	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10573	10573	G	T	MI.15908	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	104	35	G	V	gGa/gTa	2.83	1	0	probably_damaging	1	neutral	0.55	neutral	2	neutral	-0.02	deleterious	-8.59	medium_impact	3.06	0.73	neutral	0.25	damaging	3.65	23.20	deleterious	0.35	0.5	0.33	neutral	0.8	disease	0.59	disease	0.7	disease	4	1	deleterious	0.28	neutral	1	deleterious	0.73	deleterious	-3.55	low_impact	0.26	medium_impact	1.43	medium_impact	0.49	0.8	54.08	11.89	0.39	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10575	10575	A	T	MI.15909	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	106	36	M	L	Ata/Tta	-9.85	0	0	benign	0.12	neutral	1	neutral	1.88	neutral	-0.85	deleterious	-2.73	medium_impact	2.31	0.84	neutral	0.71	neutral	1.43	12.94	neutral	0.49	0.55	0.23	neutral	0.75	disease	0.56	disease	0.55	disease	1	0.12	neutral	0.94	deleterious	-3	neutral	0.21	neutral	-0.01	medium_impact	1.88	high_impact	0.8	medium_impact	0.52	0.8	56.12	11.55	0.26	N	0.52	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8435	8435	A	C	MI.1591	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	70	24	T	P	Acc/Ccc	-4.5	0	0.01	possibly_damaging	0.66	neutral	0.2	neutral	1.93	deleterious	-5.61	deleterious	-2.74	medium_impact	2.51	0.99	neutral	0.41	neutral	2.95	22.10	deleterious	0.27857120	0.85	0.57	disease	0.55	disease	0.68	disease	0.63	disease	3	0.82	neutral	0.27	neutral	0	NA	0.62	deleterious	-1.03	low_impact	-0.05	medium_impact	1.05	medium_impact	0.68	0.85	NA	NA	0.51	N	0.61	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10575	10575	A	C	MI.15910	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	106	36	M	L	Ata/Cta	-9.85	0	0	benign	0.12	neutral	1	neutral	1.88	neutral	-0.85	deleterious	-2.73	medium_impact	2.31	0.84	neutral	0.71	neutral	1.32	12.39	neutral	0.49	0.55	0.23	neutral	0.75	disease	0.56	disease	0.55	disease	1	0.12	neutral	0.94	deleterious	-3	neutral	0.21	neutral	-0.01	medium_impact	1.88	high_impact	0.8	medium_impact	0.52	0.8	56.12	11.55	0.26	N	0.52	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10575	10575	A	G	MI.15911	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	106	36	M	V	Ata/Gta	-9.85	0	0	benign	0.18	neutral	0.37	neutral	1.72	neutral	-1.48	deleterious	-3.63	medium_impact	2.98	0.75	neutral	0.59	neutral	0.84	9.69	deleterious	0.62	0.65	0.18	neutral	0.74	disease	0.59	disease	0.63	disease	3	0.56	neutral	0.6	deleterious	-3	neutral	0.20	neutral	-0.2	medium_impact	0.08	medium_impact	1.36	medium_impact	0.42	0.8	56.12	11.55	0.38	N	0.48	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10576	10576	T	A	MI.15912	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	107	36	M	K	aTa/aAa	3.98	0.99	0	possibly_damaging	0.84	neutral	0.12	neutral	1.63	deleterious	-5.19	deleterious	-5.7	high_impact	4.39	0.67	neutral	0.35	neutral	3.81	23.40	deleterious	0.22	0.45	0.77	disease	0.89	disease	0.75	disease	0.8	disease	6	0.94	neutral	0.14	neutral	1	deleterious	0.71	deleterious	-1.46	low_impact	-0.27	medium_impact	2.54	high_impact	0.33	0.8	56.12	11.55	0.62	P	0.87	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10576	10576	T	C	MI.15913	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	107	36	M	T	aTa/aCa	3.98	0.99	0	possibly_damaging	0.73	neutral	0.19	neutral	1.67	deleterious	-3.96	deleterious	-5.58	medium_impact	3.5	0.82	neutral	0.55	neutral	2.52	19.62	deleterious	0.51	0.6	0.59	disease	0.77	disease	0.68	disease	0.66	disease	3	0.86	neutral	0.23	neutral	0	NA	0.54	deleterious	-1.2	low_impact	-0.14	medium_impact	1.8	medium_impact	0.32	0.8	56.12	11.55	0.57	P	0.42	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10577	10577	A	T	MI.15914	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	108	36	M	I	atA/atT	7.44	1	0	benign	0.03	neutral	0.31	neutral	1.94	neutral	-0.87	deleterious	-3.59	low_impact	1.8	0.92	neutral	0.64	neutral	0.37	6.33	deleterious	0.5	0.6	0.2	neutral	0.79	disease	0.54	disease	0.55	disease	1	0.67	neutral	0.64	deleterious	-6	neutral	0.18	neutral	0.58	medium_impact	0.02	medium_impact	0.37	medium_impact	0.56	0.8	56.12	11.55	0.61	P	0.05	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10577	10577	A	C	MI.15915	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	108	36	M	I	atA/atC	7.44	1	0	benign	0.03	neutral	0.31	neutral	1.94	neutral	-0.87	deleterious	-3.59	low_impact	1.8	0.92	neutral	0.64	neutral	0.31	5.78	deleterious	0.5	0.6	0.2	neutral	0.79	disease	0.54	disease	0.55	disease	1	0.67	neutral	0.64	deleterious	-6	neutral	0.18	neutral	0.58	medium_impact	0.02	medium_impact	0.37	medium_impact	0.56	0.8	56.12	11.55	0.61	P	0.05	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10578	10578	A	C	MI.15916	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	109	37	M	L	Ata/Cta	0.29	0.98	0	benign	0.02	neutral	0.86	neutral	2.01	neutral	1.65	deleterious	-2.67	medium_impact	2.06	0.83	neutral	0.56	neutral	1.30	12.29	neutral	0.62	0.65	0.14	neutral	0.78	disease	0.52	disease	0.62	disease	2	0.1	neutral	0.92	deleterious	-3	neutral	0.20	neutral	0.75	medium_impact	0.65	medium_impact	0.59	medium_impact	0.48	0.8	56.12	10.37	0.36	N	0.47	polymorphism	0.65	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10578	10578	A	T	MI.15917	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	109	37	M	L	Ata/Tta	0.29	0.98	0	benign	0.02	neutral	0.86	neutral	2.01	neutral	1.65	deleterious	-2.67	medium_impact	2.06	0.83	neutral	0.56	neutral	1.37	12.65	neutral	0.62	0.65	0.14	neutral	0.78	disease	0.52	disease	0.62	disease	2	0.1	neutral	0.92	deleterious	-3	neutral	0.20	neutral	0.75	medium_impact	0.65	medium_impact	0.59	medium_impact	0.48	0.8	56.12	10.37	0.36	N	0.47	polymorphism	0.65	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10578	10578	A	G	MI.15918	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	109	37	M	V	Ata/Gta	0.29	0.98	0	benign	0.1	neutral	0.31	neutral	1.88	neutral	-0.05	deleterious	-3.52	low_impact	1.52	0.85	neutral	0.71	neutral	0.81	9.50	deleterious	0.7	0.75	0.12	neutral	0.72	disease	0.51	disease	0.53	disease	1	0.65	neutral	0.61	deleterious	-6	neutral	0.18	neutral	0.07	medium_impact	0.02	medium_impact	0.14	medium_impact	0.28	0.8	56.12	10.37	0.41	N	0.15	polymorphism	0.6	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10579	10579	T	C	MI.15919	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	110	37	M	T	aTa/aCa	3.98	1	0	benign	0.04	neutral	0.13	neutral	1.86	neutral	-2.85	deleterious	-5.48	medium_impact	2.69	0.83	neutral	0.63	neutral	0.99	10.63	neutral	0.64	0.7	0.54	disease	0.76	disease	0.57	disease	0.64	disease	3	0.86	neutral	0.55	deleterious	-3	neutral	0.27	neutral	0.46	medium_impact	-0.25	medium_impact	1.12	medium_impact	0.28	0.8	56.12	10.37	0.52	N	0.63	disease_causing	0.73	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8435	8435	A	G	MI.1592	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	70	24	T	A	Acc/Gcc	-4.5	0	0.01	benign	0.1	neutral	0.31	neutral	1.98	deleterious	-3.44	neutral	-1.14	low_impact	1.71	0.99	neutral	0.74	neutral	0.37	6.33	deleterious	0.57262910	0.85	0.24	neutral	0.16	neutral	0.53	disease	0.2	neutral	6	0.65	neutral	0.61	deleterious	-6	neutral	0.20	neutral	0.15	medium_impact	0.1	medium_impact	0.37	medium_impact	0.59	0.85	NA	NA	0.52	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10579	10579	T	A	MI.15920	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	110	37	M	K	aTa/aAa	3.98	1	0	possibly_damaging	0.57	deleterious	0.04	neutral	1.83	deleterious	-4.12	deleterious	-5.63	high_impact	4.3	0.64	neutral	0.36	neutral	2.34	18.44	deleterious	0.3	0.45	0.72	disease	0.89	disease	0.74	disease	0.8	disease	6	0.96	neutral	0.24	neutral	5	deleterious	0.51	deleterious	-0.92	medium_impact	-0.56	medium_impact	2.47	high_impact	0.39	0.8	56.12	10.37	0.6	P	0.90	disease_causing	0.95	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10580	10580	A	C	MI.15921	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	111	37	M	I	atA/atC	5.83	1	0	benign	0.02	neutral	0.36	neutral	1.86	neutral	-0.69	deleterious	-3.5	medium_impact	2.54	0.89	neutral	0.74	neutral	1.32	12.39	neutral	0.52	0.6	0.24	neutral	0.79	disease	0.62	disease	0.66	disease	3	0.63	neutral	0.67	deleterious	-3	neutral	0.21	neutral	0.75	medium_impact	0.07	medium_impact	0.99	medium_impact	0.49	0.8	56.12	10.37	0.63	P	0.08	disease_causing	0.75	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10580	10580	A	T	MI.15922	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	111	37	M	I	atA/atT	5.83	1	0	benign	0.02	neutral	0.36	neutral	1.86	neutral	-0.69	deleterious	-3.5	medium_impact	2.54	0.89	neutral	0.74	neutral	1.37	12.65	neutral	0.52	0.6	0.24	neutral	0.79	disease	0.62	disease	0.66	disease	3	0.63	neutral	0.67	deleterious	-3	neutral	0.21	neutral	0.75	medium_impact	0.07	medium_impact	0.99	medium_impact	0.49	0.8	56.12	10.37	0.63	P	0.08	disease_causing	0.75	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10581	10581	C	G	MI.15923	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	112	38	L	V	Cta/Gta	1.21	0.57	0	possibly_damaging	0.68	neutral	0.22	neutral	1.68	neutral	-1.99	deleterious	-2.75	medium_impact	3.26	0.58	damaging	0.45	neutral	1.61	13.93	neutral	0.53	0.6	0.62	disease	0.5	neutral	0.6	disease	0.6	disease	2	0.82	neutral	0.27	neutral	0	NA	0.68	deleterious	-1.1	low_impact	-0.1	medium_impact	1.59	medium_impact	0.68	0.85	48.98	10.58	0.43	N	0.43	disease_causing	0.97	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10581	10581	C	A	MI.15924	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	112	38	L	M	Cta/Ata	1.21	0.57	0	possibly_damaging	0.68	neutral	0.14	neutral	1.64	deleterious	-3.74	neutral	-1.88	medium_impact	2.94	0.67	neutral	0.62	neutral	1.71	14.46	neutral	0.4	0.5	0.69	disease	0.53	disease	0.59	disease	0.58	disease	2	0.88	neutral	0.23	neutral	0	NA	0.47	deleterious	-1.1	low_impact	-0.23	medium_impact	1.33	medium_impact	0.62	0.8	48.98	10.58	0.39	N	0.08	disease_causing	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10582	10582	T	A	MI.15925	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	113	38	L	Q	cTa/cAa	-4.78	0	0	probably_damaging	0.98	deleterious	0.02	neutral	1.65	deleterious	-4.15	deleterious	-5.74	high_impact	4.68	0.55	damaging	0.33	neutral	4.09	23.70	deleterious	0.31	0.45	0.9	disease	0.76	disease	0.67	disease	0.79	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.35	low_impact	-0.73	medium_impact	2.78	high_impact	0.66	0.8	48.98	10.58	0.47	N	0.92	disease_causing	0.64	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10582	10582	T	C	MI.15926	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	113	38	L	P	cTa/cCa	-4.78	0	0	probably_damaging	0.99	deleterious	0.01	neutral	1.62	deleterious	-5.09	deleterious	-6.7	high_impact	4.68	0.43	damaging	0.32	neutral	3.83	23.40	deleterious	0.28	0.45	0.92	disease	0.79	disease	0.76	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.63	low_impact	-0.9	medium_impact	2.78	high_impact	0.61	0.8	48.98	10.58	0.61	P	0.96	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10582	10582	T	G	MI.15927	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	113	38	L	R	cTa/cGa	-4.78	0	0	probably_damaging	0.98	deleterious	0.02	neutral	1.64	deleterious	-4.09	deleterious	-5.74	high_impact	4.68	0.5	damaging	0.25	damaging	3.96	23.60	deleterious	0.24	0.45	0.89	disease	0.85	disease	0.77	disease	0.85	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-2.35	low_impact	-0.73	medium_impact	2.78	high_impact	0.58	0.8	48.98	10.58	0.57	P	0.94	disease_causing	0.69	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10584	10584	T	G	MI.15928	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	115	39	S	A	Tcg/Gcg	-2.24	0	0	possibly_damaging	0.64	neutral	0.51	neutral	2.12	neutral	0.44	neutral	-2.44	medium_impact	2.04	0.78	neutral	0.92	neutral	0.54	7.71	deleterious	0.59	0.65	0.29	neutral	0.34	neutral	0.36	neutral	0.43	neutral	1	0.62	neutral	0.44	neutral	0	NA	0.45	deleterious	-1.03	low_impact	0.22	medium_impact	0.57	medium_impact	0.72	0.85	53.06	11.18	0.36	N	0.42	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10584	10584	T	C	MI.15929	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	115	39	S	P	Tcg/Ccg	-2.24	0	0	benign	0.08	neutral	0.2	neutral	1.62	deleterious	-4.97	deleterious	-4.2	high_impact	4.25	0.77	neutral	0.46	neutral	1.90	15.60	deleterious	0.24	0.45	0.68	disease	0.87	disease	0.68	disease	0.76	disease	5	0.78	neutral	0.56	deleterious	-2	neutral	0.31	neutral	0.17	medium_impact	-0.12	medium_impact	2.42	high_impact	0.59	0.8	53.06	11.18	0.44	N	0.95	polymorphism	1	0.27	.	.	.	.	.	.	COSM1155497	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8435	8435	A	T	MI.1593	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	70	24	T	S	Acc/Tcc	-4.5	0	0.01	benign	0.22	neutral	0.36	neutral	2.11	deleterious	-3.88	neutral	-1.07	low_impact	1.71	0.99	neutral	0.62	neutral	1.36	12.56	neutral	0.48138703	0.85	0.32	neutral	0.16	neutral	0.51	disease	0.2	neutral	6	0.57	neutral	0.57	deleterious	-6	neutral	0.25	neutral	-0.23	medium_impact	0.15	medium_impact	0.37	medium_impact	0.76	0.85	NA	NA	0.51	N	0.40	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10584	10584	T	A	MI.15930	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	115	39	S	T	Tcg/Acg	-2.24	0	0	benign	0.12	neutral	0.39	neutral	1.7	neutral	-2.22	neutral	-2.43	medium_impact	2.34	0.81	neutral	0.87	neutral	1.66	14.19	neutral	0.53	0.6	0.45	neutral	0.39	neutral	0.38	neutral	0.43	neutral	1	0.55	neutral	0.64	deleterious	-3	neutral	0.21	neutral	-0.01	medium_impact	0.1	medium_impact	0.82	medium_impact	0.83	0.9	53.06	11.18	0.41	N	0.69	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10585	10585	C	T	MI.15931	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	116	39	S	L	tCg/tTg	0.52	0.3	0	possibly_damaging	0.83	neutral	0.65	neutral	1.63	deleterious	-4.14	deleterious	-5.35	medium_impact	3.15	0.75	neutral	0.6	neutral	4.17	23.80	deleterious	0.38	0.5	0.49	neutral	0.85	disease	0.52	disease	0.71	disease	4	0.8	neutral	0.41	neutral	0	NA	0.63	deleterious	-1.43	low_impact	0.36	medium_impact	1.5	medium_impact	0.84	0.9	53.06	11.18	0.35	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10585	10585	C	G	MI.15932	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	116	39	S	W	tCg/tGg	0.52	0.3	0	probably_damaging	0.98	neutral	0.18	neutral	1.61	deleterious	-7.44	deleterious	-6.39	high_impact	4.25	0.65	neutral	0.32	neutral	4.18	23.80	deleterious	0.23	0.45	0.89	disease	0.88	disease	0.61	disease	0.79	disease	6	0.99	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-2.35	low_impact	-0.16	medium_impact	2.42	high_impact	0.41	0.8	53.06	11.18	0.4	N	0.99	disease_causing	0.62	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10587	10587	C	G	MI.15933	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	118	40	L	V	Ctg/Gtg	-20	0	0	probably_damaging	1	neutral	0.19	neutral	2.01	neutral	0.04	neutral	-2.03	medium_impact	1.99	0.76	neutral	0.28	damaging	3.21	22.70	deleterious	0.49	0.55	0.39	neutral	0.47	neutral	0.44	neutral	0.47	neutral	1	1	deleterious	0.1	neutral	1	deleterious	0.71	deleterious	-3.55	low_impact	-0.14	medium_impact	0.53	medium_impact	0.62	0.8	50	8.6	0.33	N	0.67	polymorphism	1	0.03	rs879216682	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10587	10587	C	A	MI.15934	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	118	40	L	M	Ctg/Atg	-20	0	0	probably_damaging	1	neutral	0.19	neutral	1.71	neutral	-2.88	neutral	-0.75	medium_impact	2.1	0.79	neutral	0.88	neutral	2.30	18.15	deleterious	0.39	0.5	0.39	neutral	0.24	neutral	0.42	neutral	0.43	neutral	1	1	deleterious	0.1	neutral	1	deleterious	0.68	deleterious	-3.55	low_impact	-0.14	medium_impact	0.62	medium_impact	0.66	0.8	50	8.6	0.4	N	0.62	polymorphism	1	0.02	rs879216682	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10588	10588	T	A	MI.15935	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	119	40	L	Q	cTg/cAg	-2.24	0	0	probably_damaging	1	deleterious	0.02	neutral	1.68	deleterious	-4.44	deleterious	-4.68	high_impact	3.92	0.71	neutral	0.07	damaging	4.01	23.60	deleterious	0.13	0.4	0.71	disease	0.74	disease	0.62	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.55	low_impact	-0.73	medium_impact	2.15	high_impact	0.73	0.85	50	8.6	0.31	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10588	10588	T	G	MI.15936	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	119	40	L	R	cTg/cGg	-2.24	0	0	probably_damaging	1	deleterious	0.02	neutral	1.68	deleterious	-4.26	deleterious	-4.92	high_impact	4.26	0.63	neutral	0.04	damaging	4.05	23.70	deleterious	0.1	0.4	0.7	disease	0.86	disease	0.73	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.55	low_impact	-0.73	medium_impact	2.43	high_impact	0.56	0.8	50	8.6	0.37	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10588	10588	T	C	MI.15937	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	119	40	L	P	cTg/cCg	-2.24	0	0	probably_damaging	1	deleterious	0.01	neutral	1.68	deleterious	-4.84	deleterious	-5.78	high_impact	4.26	0.68	neutral	0.08	damaging	3.78	23.40	deleterious	0.12	0.4	0.79	disease	0.82	disease	0.72	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.55	low_impact	-0.9	medium_impact	2.43	high_impact	0.66	0.8	50	8.6	0.33	N	0.95	polymorphism	0.69	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10590	10590	T	A	MI.15938	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	121	41	F	I	Ttc/Atc	-3.17	0	0	possibly_damaging	0.75	neutral	0.45	neutral	1.87	neutral	-1.18	deleterious	-5.71	high_impact	3.51	0.77	neutral	0.54	neutral	4.19	23.80	deleterious	0.39	0.5	0.48	neutral	0.9	disease	0.7	disease	0.8	disease	6	0.74	neutral	0.35	neutral	1	deleterious	0.64	deleterious	-1.24	low_impact	0.16	medium_impact	1.8	medium_impact	0.62	0.8	55.1	11.99	0.41	N	0.66	polymorphism	0.95	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10590	10590	T	C	MI.15939	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	121	41	F	L	Ttc/Ctc	-3.17	0	0	benign	0.12	neutral	0.84	neutral	1.9	neutral	-0.81	deleterious	-5.71	medium_impact	2.98	0.78	neutral	0.56	neutral	2.16	17.22	deleterious	0.58	0.65	0.3	neutral	0.86	disease	0.65	disease	0.7	disease	4	0.07	neutral	0.86	deleterious	-3	neutral	0.23	neutral	-0.01	medium_impact	0.61	medium_impact	1.36	medium_impact	0.59	0.8	55.1	11.99	0.27	N	0.89	polymorphism	0.95	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8436	8436	C	A	MI.1594	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	71	24	T	N	aCc/aAc	-2.88	0	0	possibly_damaging	0.54	neutral	0.39	neutral	1.95	deleterious	-5.08	neutral	-2.07	medium_impact	2.51	0.99	neutral	0.62	neutral	3.18	22.70	deleterious	0.48647755	0.85	0.49	neutral	0.31	neutral	0.57	disease	0.18	neutral	7	0.61	neutral	0.43	neutral	0	NA	0.58	deleterious	-0.82	medium_impact	0.18	medium_impact	1.05	medium_impact	0.68	0.85	NA	NA	0.49	N	0.51	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10590	10590	T	G	MI.15940	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	121	41	F	V	Ttc/Gtc	-3.17	0	0	possibly_damaging	0.83	neutral	0.34	neutral	1.88	neutral	-1.05	deleterious	-6.64	high_impact	3.51	0.7	neutral	0.45	neutral	3.90	23.50	deleterious	0.39	0.5	0.52	disease	0.9	disease	0.71	disease	0.8	disease	6	0.85	neutral	0.26	neutral	1	deleterious	0.67	deleterious	-1.43	low_impact	0.05	medium_impact	1.8	medium_impact	0.62	0.8	55.1	11.99	0.39	N	0.90	polymorphism	0.9	0.11	rs28532736	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10591	10591	T	G	MI.15941	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	122	41	F	C	tTc/tGc	5.83	1	0	probably_damaging	0.98	neutral	0.05	neutral	1.78	deleterious	-4.15	deleterious	-7.64	high_impact	4.55	0.65	neutral	0.42	neutral	4.03	23.70	deleterious	0.37	0.5	0.87	disease	0.91	disease	0.7	disease	0.81	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-2.35	low_impact	-0.5	medium_impact	2.68	high_impact	0.28	0.8	55.1	11.99	0.67	P	0.96	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	T10591G	LHON	-	+	Reported	1	.	P	P	damaging
chrM	10591	10591	T	C	MI.15942	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	122	41	F	S	tTc/tCc	5.83	1	0	probably_damaging	0.96	neutral	0.4	neutral	1.82	neutral	-2.14	deleterious	-7.57	high_impact	3.75	0.72	neutral	0.54	neutral	4.17	23.80	deleterious	0.38	0.5	0.77	disease	0.89	disease	0.68	disease	0.76	disease	5	0.96	neutral	0.22	neutral	2	deleterious	0.81	deleterious	-2.07	low_impact	0.11	medium_impact	2.01	high_impact	0.40	0.8	55.1	11.99	0.68	P	0.97	disease_causing	0.99	0.11	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10591	10591	T	A	MI.15943	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	122	41	F	Y	tTc/tAc	5.83	1	0	benign	0.17	neutral	0.59	neutral	1.83	neutral	-1.97	deleterious	-2.66	medium_impact	2.17	0.79	neutral	0.7	neutral	2.63	20.40	deleterious	0.41	0.5	0.52	disease	0.61	disease	0.58	disease	0.47	neutral	1	0.3	neutral	0.71	deleterious	-3	neutral	0.70	deleterious	-0.17	medium_impact	0.3	medium_impact	0.68	medium_impact	0.61	0.8	55.1	11.99	0.57	P	0.85	disease_causing	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10592	10592	C	A	MI.15944	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	123	41	F	L	ttC/ttA	2.83	0.99	0	benign	0.12	neutral	0.84	neutral	1.9	neutral	-0.81	deleterious	-5.71	medium_impact	2.98	0.78	neutral	0.56	neutral	2.83	21.50	deleterious	0.58	0.65	0.3	neutral	0.86	disease	0.65	disease	0.7	disease	4	0.07	neutral	0.86	deleterious	-3	neutral	0.23	neutral	-0.01	medium_impact	0.61	medium_impact	1.36	medium_impact	0.59	0.8	55.1	11.99	0.42	N	0.89	disease_causing	0.93	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10592	10592	C	G	MI.15945	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	123	41	F	L	ttC/ttG	2.83	0.99	0	benign	0.12	neutral	0.84	neutral	1.9	neutral	-0.81	deleterious	-5.71	medium_impact	2.98	0.78	neutral	0.56	neutral	2.49	19.41	deleterious	0.58	0.65	0.3	neutral	0.86	disease	0.65	disease	0.7	disease	4	0.07	neutral	0.86	deleterious	-3	neutral	0.23	neutral	-0.01	medium_impact	0.61	medium_impact	1.36	medium_impact	0.59	0.8	55.1	11.99	0.42	N	0.89	disease_causing	0.93	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10593	10593	A	C	MI.15946	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	124	42	I	L	Att/Ctt	-4.78	0	0	benign	0.26	neutral	1	neutral	2.39	neutral	1.61	neutral	-1.35	low_impact	1.29	0.78	neutral	0.76	neutral	0.82	9.60	deleterious	0.38	0.5	0.19	neutral	0.53	disease	0.3	neutral	0.44	neutral	1	0.26	neutral	0.87	deleterious	-6	neutral	0.21	neutral	-0.39	medium_impact	1.88	high_impact	-0.06	medium_impact	0.41	0.8	15.31	9.67	0.29	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10593	10593	A	T	MI.15947	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	124	42	I	F	Att/Ttt	-4.78	0	0	possibly_damaging	0.87	neutral	0.64	neutral	1.85	neutral	-1.51	deleterious	-3.18	low_impact	1.5	0.69	neutral	0.42	neutral	3.44	23.00	deleterious	0.41	0.5	0.18	neutral	0.69	disease	0.38	neutral	0.53	disease	1	0.85	neutral	0.39	neutral	-3	neutral	0.62	deleterious	-1.56	low_impact	0.35	medium_impact	0.12	medium_impact	0.56	0.8	15.31	9.67	0.3	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10593	10593	A	G	MI.15948	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	124	42	I	V	Att/Gtt	-4.78	0	0	possibly_damaging	0.53	neutral	0.48	neutral	1.9	neutral	-0.87	neutral	-0.33	low_impact	0.82	0.85	neutral	0.99	neutral	-0.12	1.58	neutral	0.59	0.65	0.16	neutral	0.27	neutral	0.38	neutral	0.43	neutral	1	0.53	neutral	0.48	deleterious	-3	neutral	0.35	neutral	-0.85	medium_impact	0.19	medium_impact	-0.45	medium_impact	0.38	0.8	15.31	9.67	0.32	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10594	10594	T	C	MI.15949	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	125	42	I	T	aTt/aCt	-1.55	0	0	benign	0.13	neutral	0.18	neutral	1.83	neutral	-2	deleterious	-2.92	medium_impact	2.1	0.84	neutral	0.97	neutral	2.85	21.60	deleterious	0.53	0.6	0.38	neutral	0.61	disease	0.41	neutral	0.48	neutral	0	0.79	neutral	0.53	deleterious	-3	neutral	0.57	deleterious	-0.05	medium_impact	-0.16	medium_impact	0.62	medium_impact	0.64	0.8	15.31	9.67	0.45	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	COSM1138224	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8436	8436	C	T	MI.1595	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	71	24	T	I	aCc/aTc	-2.88	0	0	benign	0	neutral	0.67	neutral	2.19	deleterious	-3.48	neutral	0.58	neutral_impact	0.18	1	neutral	0.87	neutral	0.26	5.29	deleterious	0.56070775	0.85	0.28	neutral	0.3	neutral	0.37	neutral	0.14	neutral	7	0.32	neutral	0.84	deleterious	-6	neutral	0.17	neutral	2.09	high_impact	0.47	medium_impact	-0.94	medium_impact	0.64	0.85	NA	NA	0.31	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10594	10594	T	G	MI.15950	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	125	42	I	S	aTt/aGt	-1.55	0	0	possibly_damaging	0.76	neutral	0.61	neutral	1.82	neutral	-2.12	deleterious	-4.26	medium_impact	2.52	0.77	neutral	0.48	neutral	3.83	23.40	deleterious	0.38	0.5	0.44	neutral	0.8	disease	0.52	disease	0.67	disease	3	0.72	neutral	0.43	neutral	0	NA	0.57	deleterious	-1.26	low_impact	0.32	medium_impact	0.97	medium_impact	0.52	0.8	15.31	9.67	0.22	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10594	10594	T	A	MI.15951	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	125	42	I	N	aTt/aAt	-1.55	0	0	benign	0.11	neutral	0.11	neutral	1.78	deleterious	-3.93	deleterious	-5.26	high_impact	3.85	0.74	neutral	0.36	neutral	2.44	19.06	deleterious	0.3	0.45	0.6	disease	0.79	disease	0.62	disease	0.71	disease	4	0.88	neutral	0.5	deleterious	-2	neutral	0.26	neutral	0.03	medium_impact	-0.29	medium_impact	2.09	high_impact	0.62	0.8	15.31	9.67	0.41	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10595	10595	T	G	MI.15952	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	126	42	I	M	atT/atG	1.21	0	0	benign	0.4	neutral	0.34	neutral	1.83	neutral	-1.85	neutral	-1.65	medium_impact	1.96	0.85	neutral	0.82	neutral	0.38	6.43	deleterious	0.44	0.55	0.42	neutral	0.51	disease	0.32	neutral	0.46	neutral	1	0.6	neutral	0.47	deleterious	-3	neutral	0.26	neutral	-0.64	medium_impact	0.05	medium_impact	0.51	medium_impact	0.58	0.8	15.31	9.67	0.37	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10595	10595	T	A	MI.15953	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	126	42	I	M	atT/atA	1.21	0	0	benign	0.4	neutral	0.34	neutral	1.83	neutral	-1.85	neutral	-1.65	medium_impact	1.96	0.85	neutral	0.82	neutral	0.70	8.83	deleterious	0.44	0.55	0.42	neutral	0.51	disease	0.32	neutral	0.46	neutral	1	0.6	neutral	0.47	deleterious	-3	neutral	0.26	neutral	-0.64	medium_impact	0.05	medium_impact	0.51	medium_impact	0.58	0.8	15.31	9.67	0.36	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10596	10596	A	T	MI.15954	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	127	43	M	L	Ata/Tta	-9.62	0	0	benign	0.01	neutral	0.94	neutral	2.16	neutral	1.51	neutral	0.23	neutral_impact	0.2	0.79	neutral	0.97	neutral	-1.12	0.01	neutral	0.5	0.6	0.4	neutral	0.46	neutral	0.31	neutral	0.48	neutral	1	0.04	neutral	0.97	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.87	medium_impact	-0.97	medium_impact	0.58	0.8	22.45	8.75	0.33	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10596	10596	A	C	MI.15955	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	127	43	M	L	Ata/Cta	-9.62	0	0	benign	0.01	neutral	0.94	neutral	2.16	neutral	1.51	neutral	0.23	neutral_impact	0.2	0.79	neutral	0.97	neutral	-1.19	0.01	neutral	0.5	0.6	0.4	neutral	0.46	neutral	0.31	neutral	0.48	neutral	1	0.04	neutral	0.97	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.87	medium_impact	-0.97	medium_impact	0.58	0.8	22.45	8.75	0.33	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10596	10596	A	G	MI.15956	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	127	43	M	V	Ata/Gta	-9.62	0	0	benign	0.02	neutral	0.53	neutral	2.03	neutral	0.36	neutral	-1.5	medium_impact	2.53	0.74	neutral	0.72	neutral	-0.74	0.06	neutral	0.58	0.65	0.39	neutral	0.57	disease	0.48	neutral	0.54	disease	1	0.45	neutral	0.76	deleterious	-3	neutral	0.20	neutral	0.75	medium_impact	0.24	medium_impact	0.98	medium_impact	0.52	0.8	22.45	8.75	0.36	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10597	10597	T	C	MI.15957	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	128	43	M	T	aTa/aCa	-3.4	0	0	benign	0.01	neutral	0.38	neutral	1.97	neutral	-0.46	deleterious	-3.49	medium_impact	2.53	0.83	neutral	0.86	neutral	-0.54	0.18	neutral	0.56	0.6	0.39	neutral	0.51	disease	0.4	neutral	0.46	neutral	1	0.61	neutral	0.69	deleterious	-3	neutral	0.18	neutral	1.03	medium_impact	0.09	medium_impact	0.98	medium_impact	0.46	0.8	22.45	8.75	0.4	N	0.66	polymorphism	1	0.07	.	.	.	.	.	.	COSM1155498	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10597	10597	T	A	MI.15958	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	128	43	M	K	aTa/aAa	-3.4	0	0	benign	0.34	neutral	0.27	neutral	1.93	neutral	-2.22	deleterious	-4.33	high_impact	3.68	0.73	neutral	0.38	neutral	0.95	10.37	neutral	0.29	0.45	0.45	neutral	0.8	disease	0.6	disease	0.77	disease	5	0.68	neutral	0.47	neutral	-2	neutral	0.44	deleterious	-0.54	medium_impact	-0.03	medium_impact	1.95	medium_impact	0.53	0.8	22.45	8.75	0.41	N	0.87	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10598	10598	A	T	MI.15959	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	129	43	M	I	atA/atT	2.37	0.02	0	benign	0.01	neutral	0.63	neutral	2.02	neutral	0.31	neutral	-0.83	low_impact	1.5	0.8	neutral	0.94	neutral	-0.07	1.95	neutral	0.48	0.55	0.46	neutral	0.58	disease	0.35	neutral	0.48	neutral	1	0.36	neutral	0.81	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	0.34	medium_impact	0.12	medium_impact	0.66	0.8	22.45	8.75	0.28	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8436	8436	C	G	MI.1596	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	71	24	T	S	aCc/aGc	-2.88	0	0	benign	0.22	neutral	0.36	neutral	2.11	deleterious	-3.88	neutral	-1.07	low_impact	1.71	0.99	neutral	0.62	neutral	1.60	13.83	neutral	0.48138703	0.85	0.32	neutral	0.16	neutral	0.51	disease	0.2	neutral	6	0.57	neutral	0.57	deleterious	-6	neutral	0.25	neutral	-0.23	medium_impact	0.15	medium_impact	0.37	medium_impact	0.76	0.85	NA	NA	0.51	N	0.40	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10598	10598	A	C	MI.15960	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	129	43	M	I	atA/atC	2.37	0.02	0	benign	0.01	neutral	0.63	neutral	2.02	neutral	0.31	neutral	-0.83	low_impact	1.5	0.8	neutral	0.94	neutral	-0.17	1.29	neutral	0.48	0.55	0.46	neutral	0.58	disease	0.35	neutral	0.48	neutral	1	0.36	neutral	0.81	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	0.34	medium_impact	0.12	medium_impact	0.66	0.8	22.45	8.75	0.28	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10599	10599	G	T	MI.15961	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	130	44	A	S	Gct/Tct	-2.71	0	0	benign	0	neutral	0.2	neutral	1.97	neutral	-0.7	neutral	0.22	neutral_impact	0.07	0.86	neutral	0.93	neutral	0.13	3.88	deleterious	0.4	0.5	0.17	neutral	0.24	neutral	0.24	neutral	0.44	neutral	1	0.8	neutral	0.6	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	-0.12	medium_impact	-1.08	low_impact	0.74	0.85	25.51	23.13	0.45	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10599	10599	G	A	MI.15962	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	130	44	A	T	Gct/Act	-2.71	0	0	benign	0.01	neutral	0.08	neutral	2	neutral	0.02	neutral	-0.16	neutral_impact	-0.58	0.85	neutral	0.98	neutral	0.74	9.08	deleterious	0.4	0.5	0.13	neutral	0.21	neutral	0.25	neutral	0.37	neutral	3	0.92	neutral	0.54	deleterious	-6	neutral	0.09	neutral	1.03	medium_impact	-0.38	medium_impact	-1.62	low_impact	0.62	0.8	25.51	23.13	0.43	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10599	10599	G	C	MI.15963	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	130	44	A	P	Gct/Cct	-2.71	0	0	benign	0.42	deleterious	0.02	neutral	1.94	neutral	-2.52	neutral	-2.23	low_impact	1.9	0.73	neutral	0.42	neutral	1.88	15.45	deleterious	0.19	0.45	0.35	neutral	0.73	disease	0.62	disease	0.76	disease	5	0.98	neutral	0.3	neutral	-2	neutral	0.29	neutral	-0.68	medium_impact	-0.73	medium_impact	0.46	medium_impact	0.77	0.85	25.51	23.13	0.32	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10600	10600	C	A	MI.15964	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	131	44	A	D	gCt/gAt	-4.55	0	0	benign	0.18	deleterious	0.02	neutral	1.93	deleterious	-3.16	neutral	-1.95	low_impact	1.9	0.71	neutral	0.37	neutral	2.56	19.85	deleterious	0.22	0.45	0.46	neutral	0.69	disease	0.62	disease	0.75	disease	5	0.98	neutral	0.42	neutral	-2	neutral	0.23	neutral	-0.2	medium_impact	-0.73	medium_impact	0.46	medium_impact	0.66	0.8	25.51	23.13	0.34	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10600	10600	C	G	MI.15965	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	131	44	A	G	gCt/gGt	-4.55	0	0	benign	0.01	neutral	0.08	neutral	1.95	neutral	-1.75	neutral	-1.4	neutral_impact	0.66	0.86	neutral	0.9	neutral	0.78	9.34	deleterious	0.25	0.45	0.36	neutral	0.37	neutral	0.46	neutral	0.47	neutral	1	0.92	neutral	0.54	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	-0.38	medium_impact	-0.59	medium_impact	0.73	0.85	25.51	23.13	0.47	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10600	10600	C	T	MI.15966	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	131	44	A	V	gCt/gTt	-4.55	0	0	benign	0.04	neutral	0.24	neutral	2.07	neutral	0.94	neutral	-1.06	neutral_impact	-0.32	0.82	neutral	0.9	neutral	1.16	11.51	neutral	0.48	0.55	0.14	neutral	0.37	neutral	0.29	neutral	0.46	neutral	1	0.74	neutral	0.6	deleterious	-6	neutral	0.11	neutral	0.46	medium_impact	-0.07	medium_impact	-1.41	low_impact	0.66	0.8	25.51	23.13	0.37	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10602	10602	A	G	MI.15967	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	133	45	T	A	Act/Gct	-13.08	0	0	benign	0.03	neutral	0.54	neutral	2.04	neutral	0.48	neutral	-1.71	neutral_impact	0.7	0.85	neutral	0.99	neutral	-0.32	0.60	neutral	0.61	0.65	0.13	neutral	0.29	neutral	0.33	neutral	0.42	neutral	2	0.42	neutral	0.76	deleterious	-6	neutral	0.12	neutral	0.58	medium_impact	0.25	medium_impact	-0.55	medium_impact	0.45	0.8	17.35	7.83	0.34	N	0.05	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10602	10602	A	T	MI.15968	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	133	45	T	S	Act/Tct	-13.08	0	0	benign	0.08	neutral	0.74	neutral	2.01	neutral	0.21	neutral	-0.67	neutral_impact	0.28	0.81	neutral	0.99	neutral	-1.07	0.01	neutral	0.59	0.65	0.1	neutral	0.11	neutral	0.28	neutral	0.23	neutral	5	0.16	neutral	0.83	deleterious	-6	neutral	0.34	neutral	0.17	medium_impact	0.46	medium_impact	-0.9	medium_impact	0.59	0.8	17.35	7.83	0.37	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10602	10602	A	C	MI.15969	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	133	45	T	P	Act/Cct	-13.08	0	0	possibly_damaging	0.89	neutral	0.21	neutral	1.92	neutral	-2.57	deleterious	-3.54	medium_impact	3.04	0.64	neutral	0.39	neutral	3.30	22.90	deleterious	0.22	0.45	0.44	neutral	0.86	disease	0.64	disease	0.79	disease	6	0.93	neutral	0.16	neutral	0	NA	0.70	deleterious	-1.64	low_impact	-0.11	medium_impact	1.41	medium_impact	0.58	0.8	17.35	7.83	0.41	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8438	8438	C	A	MI.1597	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	73	25	Q	K	Caa/Aaa	-8.2	0	0	probably_damaging	0.94	neutral	0.29	neutral	1.58	deleterious	-4.21	deleterious	-3.99	medium_impact	2.96	0.99	neutral	0.3	neutral	3.85	23.40	deleterious	0.37595543	0.85	0.59	disease	0.58	disease	0.78	disease	0.68	disease	4	0.95	neutral	0.18	neutral	1	deleterious	0.73	deleterious	-1.89	low_impact	0.07	medium_impact	1.44	medium_impact	0.57	0.85	5.88	7.45	0.48	N	0.85	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10603	10603	C	T	MI.15970	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	134	45	T	I	aCt/aTt	-7.55	0	0	possibly_damaging	0.75	neutral	0.45	neutral	2.11	neutral	1.14	deleterious	-3.27	low_impact	1.75	0.84	neutral	0.68	neutral	2.53	19.63	deleterious	0.49	0.55	0.18	neutral	0.76	disease	0.39	neutral	0.62	disease	2	0.74	neutral	0.35	neutral	-3	neutral	0.58	deleterious	-1.24	low_impact	0.16	medium_impact	0.33	medium_impact	0.74	0.85	17.35	7.83	0.29	N	0.64	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10603	10603	C	G	MI.15971	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	134	45	T	S	aCt/aGt	-7.55	0	0	benign	0.08	neutral	0.74	neutral	2.01	neutral	0.21	neutral	-0.67	neutral_impact	0.28	0.81	neutral	0.99	neutral	-0.89	0.03	neutral	0.59	0.65	0.1	neutral	0.11	neutral	0.28	neutral	0.23	neutral	5	0.16	neutral	0.83	deleterious	-6	neutral	0.34	neutral	0.17	medium_impact	0.46	medium_impact	-0.9	medium_impact	0.59	0.8	17.35	7.83	0.37	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10603	10603	C	A	MI.15972	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	134	45	T	N	aCt/aAt	-7.55	0	0	possibly_damaging	0.75	neutral	0.25	neutral	1.92	neutral	-2.39	deleterious	-2.5	medium_impact	2.24	0.74	neutral	0.49	neutral	3.43	23.00	deleterious	0.55	0.6	0.35	neutral	0.66	disease	0.5	neutral	0.53	disease	1	0.83	neutral	0.25	neutral	0	NA	0.64	deleterious	-1.24	low_impact	-0.06	medium_impact	0.74	medium_impact	0.76	0.85	17.35	7.83	0.38	N	0.52	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10605	10605	C	T	MI.15973	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	136	46	L	F	Ctc/Ttc	-14.24	0	0	benign	0.17	neutral	0.61	neutral	1.78	neutral	-2.25	deleterious	-2.61	low_impact	1.74	0.81	neutral	0.71	neutral	2.00	16.21	deleterious	0.52	0.6	0.52	disease	0.41	neutral	0.42	neutral	0.37	neutral	3	0.28	neutral	0.72	deleterious	-6	neutral	0.18	neutral	-0.17	medium_impact	0.32	medium_impact	0.32	medium_impact	0.74	0.85	19.39	13.62	0.28	N	0.52	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10605	10605	C	G	MI.15974	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	136	46	L	V	Ctc/Gtc	-14.24	0	0	benign	0.08	neutral	0.18	neutral	1.87	neutral	-0.9	neutral	-0.9	low_impact	1.26	0.85	neutral	0.98	neutral	0.38	6.47	deleterious	0.55	0.6	0.18	neutral	0.29	neutral	0.39	neutral	0.44	neutral	1	0.8	neutral	0.55	deleterious	-6	neutral	0.11	neutral	0.17	medium_impact	-0.16	medium_impact	-0.08	medium_impact	0.72	0.85	19.39	13.62	0.43	N	0.07	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10605	10605	C	A	MI.15975	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	136	46	L	I	Ctc/Atc	-14.24	0	0	benign	0.08	neutral	0.42	neutral	1.87	neutral	-0.97	neutral	-0.4	neutral_impact	0.5	0.81	neutral	1	neutral	0.59	8.10	deleterious	0.54	0.6	0.17	neutral	0.26	neutral	0.32	neutral	0.44	neutral	1	0.53	neutral	0.67	deleterious	-6	neutral	0.12	neutral	0.17	medium_impact	0.13	medium_impact	-0.72	medium_impact	0.76	0.85	19.39	13.62	0.36	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10606	10606	T	A	MI.15976	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	137	46	L	H	cTc/cAc	-3.63	0	0	probably_damaging	0.98	neutral	0.1	neutral	1.74	deleterious	-3.89	deleterious	-4.9	high_impact	3.65	0.82	neutral	0.54	neutral	3.96	23.60	deleterious	0.3	0.45	0.79	disease	0.73	disease	0.71	disease	0.76	disease	5	0.99	deleterious	0.06	neutral	2	deleterious	0.77	deleterious	-2.35	low_impact	-0.32	medium_impact	1.92	medium_impact	0.64	0.8	19.39	13.62	0.38	N	0.87	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10606	10606	T	G	MI.15977	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	137	46	L	R	cTc/cGc	-3.63	0	0	probably_damaging	0.93	neutral	0.06	neutral	1.74	deleterious	-3.89	deleterious	-4.3	high_impact	3.65	0.71	neutral	0.29	neutral	4.07	23.70	deleterious	0.27	0.45	0.72	disease	0.83	disease	0.74	disease	0.8	disease	6	0.98	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-1.83	low_impact	-0.45	medium_impact	1.92	medium_impact	0.71	0.85	19.39	13.62	0.37	N	0.95	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10606	10606	T	C	MI.15978	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	137	46	L	P	cTc/cCc	-3.63	0	0	probably_damaging	0.95	neutral	0.07	neutral	1.73	deleterious	-3.99	deleterious	-4.8	medium_impact	3.31	0.62	neutral	0.28	damaging	3.77	23.40	deleterious	0.25	0.45	0.78	disease	0.83	disease	0.75	disease	0.8	disease	6	0.99	deleterious	0.06	neutral	1	deleterious	0.79	deleterious	-1.97	low_impact	-0.41	medium_impact	1.64	medium_impact	0.73	0.85	19.39	13.62	0.34	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10608	10608	A	C	MI.15979	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	139	47	M	L	Ata/Cta	-7.09	0	0.01	benign	0.01	neutral	0.72	neutral	2.1	neutral	1.16	neutral	0.53	neutral_impact	-1.01	0.77	neutral	0.97	neutral	-0.04	2.21	deleterious	0.56	0.6	0.11	neutral	0.4	neutral	0.34	neutral	0.43	neutral	1	0.26	neutral	0.86	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.44	medium_impact	-1.98	low_impact	0.52	0.8	24.49	10.84	0.28	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8438	8438	C	G	MI.1598	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	73	25	Q	E	Caa/Gaa	-8.2	0	0	possibly_damaging	0.87	neutral	0.27	neutral	1.59	deleterious	-4.52	deleterious	-2.99	high_impact	3.86	0.98	neutral	0.38	neutral	2.92	21.90	deleterious	0.42653776	0.85	0.64	disease	0.44	neutral	0.76	disease	0.45	neutral	1	0.9	neutral	0.2	neutral	1	deleterious	0.72	deleterious	-1.54	low_impact	0.05	medium_impact	2.21	high_impact	0.57	0.85	5.88	7.45	0.51	N	0.73	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10608	10608	A	G	MI.15980	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	139	47	M	V	Ata/Gta	-7.09	0	0.01	benign	0.04	neutral	0.44	neutral	2.07	neutral	0.82	neutral	0.35	neutral_impact	0.26	0.82	neutral	0.88	neutral	-0.33	0.55	neutral	0.62	0.65	0.14	neutral	0.45	neutral	0.47	neutral	0.47	neutral	1	0.52	neutral	0.7	deleterious	-6	neutral	0.13	neutral	0.46	medium_impact	0.15	medium_impact	-0.92	medium_impact	0.48	0.8	24.49	10.84	0.29	N	0.00	polymorphism	1	0.01	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10608	10608	A	T	MI.15981	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	139	47	M	L	Ata/Tta	-7.09	0	0.01	benign	0.01	neutral	0.72	neutral	2.1	neutral	1.16	neutral	0.53	neutral_impact	-1.01	0.77	neutral	0.97	neutral	0.06	3.21	deleterious	0.56	0.6	0.11	neutral	0.4	neutral	0.34	neutral	0.43	neutral	1	0.26	neutral	0.86	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.44	medium_impact	-1.98	low_impact	0.52	0.8	24.49	10.84	0.27	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10609	10609	T	A	MI.15982	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	140	47	M	K	aTa/aAa	-0.63	0	0.12	benign	0.26	neutral	0.23	neutral	1.94	neutral	-1.63	deleterious	-2.78	low_impact	1.65	0.68	neutral	0.48	neutral	2.17	17.34	deleterious	0.29	0.45	0.27	neutral	0.73	disease	0.58	disease	0.74	disease	5	0.72	neutral	0.49	deleterious	-6	neutral	0.33	neutral	-0.39	medium_impact	-0.08	medium_impact	0.25	medium_impact	0.55	0.8	24.49	10.84	0.35	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10609	10609	T	C	MI.15983	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	140	47	M	T	aTa/aCa	-0.63	0	0.12	benign	0.01	neutral	0.43	neutral	2	neutral	-0.05	neutral	-0.76	neutral_impact	-1.09	0.85	neutral	0.98	neutral	-0.67	0.08	neutral	0.55	0.6	0.14	neutral	0.27	neutral	0.4	neutral	0.42	neutral	2	0.56	neutral	0.71	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.14	medium_impact	-2.05	low_impact	0.34	0.8	24.49	10.84	0.25	N	0.03	polymorphism	1	0.01	rs200487531	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10610	10610	A	T	MI.15984	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	141	47	M	I	atA/atT	-0.17	0	0	benign	0.01	neutral	0.51	neutral	2.05	neutral	0.7	neutral	0.65	neutral_impact	-0.55	0.8	neutral	0.98	neutral	0.13	3.93	deleterious	0.52	0.6	0.11	neutral	0.46	neutral	0.37	neutral	0.44	neutral	1	0.48	neutral	0.75	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.22	medium_impact	-1.6	low_impact	0.54	0.8	24.49	10.84	0.3	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10610	10610	A	C	MI.15985	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	141	47	M	I	atA/atC	-0.17	0	0	benign	0.01	neutral	0.51	neutral	2.05	neutral	0.7	neutral	0.65	neutral_impact	-0.55	0.8	neutral	0.98	neutral	0.10	3.60	deleterious	0.52	0.6	0.11	neutral	0.46	neutral	0.37	neutral	0.44	neutral	1	0.48	neutral	0.75	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.22	medium_impact	-1.6	low_impact	0.54	0.8	24.49	10.84	0.29	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10611	10611	A	T	MI.15986	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	142	48	T	S	Acc/Tcc	-10.32	0	0	benign	0	neutral	0.7	neutral	2.14	neutral	1.54	neutral	-0.08	neutral_impact	-0.51	0.83	neutral	1	neutral	-1.18	0.01	neutral	0.72	0.75	0.15	neutral	0.18	neutral	0.34	neutral	0.32	neutral	4	0.29	neutral	0.85	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.41	medium_impact	-1.57	low_impact	0.78	0.85	33.67	21.31	0.37	N	0.01	polymorphism	1	0.01	rs386829106	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10611	10611	A	C	MI.15987	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	142	48	T	P	Acc/Ccc	-10.32	0	0	benign	0.2	neutral	0.27	neutral	1.97	neutral	-0.78	neutral	-2.14	low_impact	0.8	0.82	neutral	0.96	neutral	-0.17	1.24	neutral	0.24	0.45	0.18	neutral	0.68	disease	0.51	disease	0.47	neutral	1	0.68	neutral	0.54	deleterious	-6	neutral	0.32	neutral	-0.25	medium_impact	-0.03	medium_impact	-0.47	medium_impact	0.70	0.85	33.67	21.31	0.33	N	0.54	polymorphism	1	0.07	rs386829106	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10611	10611	A	G	MI.15988	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	142	48	T	A	Acc/Gcc	-10.32	0	0	benign	0	neutral	0.58	neutral	2.08	neutral	1.06	neutral	0.1	neutral_impact	0.4	0.9	neutral	0.97	neutral	-0.97	0.02	neutral	0.72	0.75	0.21	neutral	0.17	neutral	0.33	neutral	0.27	neutral	5	0.42	neutral	0.79	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	0.29	medium_impact	-0.8	medium_impact	0.50	0.8	33.67	21.31	0.37	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10612	10612	C	G	MI.15989	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	143	48	T	S	aCc/aGc	-1.09	0	0	benign	0	neutral	0.7	neutral	2.14	neutral	1.54	neutral	-0.08	neutral_impact	-0.51	0.83	neutral	1	neutral	-1.00	0.02	neutral	0.72	0.75	0.15	neutral	0.18	neutral	0.34	neutral	0.32	neutral	4	0.29	neutral	0.85	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.41	medium_impact	-1.57	low_impact	0.78	0.85	33.67	21.31	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8439	8439	A	T	MI.1599	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	74	25	Q	L	cAa/cTa	3.37	0.56	0	probably_damaging	0.94	neutral	0.65	neutral	1.64	deleterious	-5.42	deleterious	-6.99	medium_impact	2.54	0.99	neutral	0.35	neutral	3.69	23.30	deleterious	0.22571878	0.85	0.76	disease	0.63	disease	0.7	disease	0.65	disease	3	0.93	neutral	0.36	neutral	1	deleterious	0.80	deleterious	-1.89	low_impact	0.44	medium_impact	1.08	medium_impact	0.31	0.85	5.88	7.45	0.41	N	0.94	disease_causing	0.52	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10612	10612	C	T	MI.15990	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	143	48	T	I	aCc/aTc	-1.09	0	0	benign	0.01	neutral	0.56	neutral	1.99	neutral	-0.2	neutral	-0.21	neutral_impact	-0.52	0.81	neutral	0.97	neutral	0.24	5.15	deleterious	0.49	0.55	0.17	neutral	0.48	neutral	0.39	neutral	0.45	neutral	1	0.43	neutral	0.78	deleterious	-6	neutral	0.25	neutral	1.03	medium_impact	0.27	medium_impact	-1.57	low_impact	0.72	0.85	33.67	21.31	0.28	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10612	10612	C	A	MI.15991	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	143	48	T	N	aCc/aAc	-1.09	0	0	benign	0.11	neutral	0.41	neutral	1.96	neutral	-0.99	neutral	-1.92	low_impact	1.5	0.85	neutral	0.63	neutral	0.79	9.43	deleterious	0.49	0.55	0.35	neutral	0.58	disease	0.5	neutral	0.5	disease	0	0.53	neutral	0.65	deleterious	-6	neutral	0.25	neutral	0.03	medium_impact	0.12	medium_impact	0.12	medium_impact	0.82	0.85	33.67	21.31	0.32	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10614	10614	C	A	MI.15992	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	145	49	L	I	Ctc/Atc	-5.01	0	0	possibly_damaging	0.75	neutral	0.43	neutral	1.87	neutral	-1.2	neutral	-1.67	low_impact	1.29	0.76	neutral	0.74	neutral	1.14	11.44	neutral	0.71	0.75	0.41	neutral	0.42	neutral	0.37	neutral	0.46	neutral	1	0.75	neutral	0.34	neutral	-3	neutral	0.45	deleterious	-1.24	low_impact	0.14	medium_impact	-0.06	medium_impact	0.59	0.8	26.53	11.6	0.34	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10614	10614	C	T	MI.15993	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	145	49	L	F	Ctc/Ttc	-5.01	0	0	benign	0.17	neutral	0.69	neutral	1.83	neutral	-2.16	deleterious	-3.33	medium_impact	2.12	0.79	neutral	0.66	neutral	1.98	16.11	deleterious	0.54	0.6	0.33	neutral	0.57	disease	0.49	neutral	0.51	disease	0	0.19	neutral	0.76	deleterious	-3	neutral	0.19	neutral	-0.17	medium_impact	0.4	medium_impact	0.64	medium_impact	0.68	0.85	26.53	11.6	0.23	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10614	10614	C	G	MI.15994	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	145	49	L	V	Ctc/Gtc	-5.01	0	0	possibly_damaging	0.64	neutral	0.55	neutral	2.03	neutral	0.18	neutral	-2.5	low_impact	1.46	0.78	neutral	0.73	neutral	0.71	8.91	deleterious	0.56	0.6	0.36	neutral	0.41	neutral	0.49	neutral	0.46	neutral	1	0.6	neutral	0.46	neutral	-3	neutral	0.44	deleterious	-1.03	low_impact	0.26	medium_impact	0.09	medium_impact	0.72	0.85	26.53	11.6	0.26	N	0.30	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10615	10615	T	G	MI.15995	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	146	49	L	R	cTc/cGc	-0.4	0	0	probably_damaging	0.9	neutral	0.29	neutral	1.86	neutral	-1.46	deleterious	-5.11	medium_impact	3.16	0.71	neutral	0.25	damaging	4.04	23.70	deleterious	0.27	0.45	0.86	disease	0.88	disease	0.59	disease	0.79	disease	6	0.92	neutral	0.2	neutral	1	deleterious	0.80	deleterious	-1.68	low_impact	-0.01	medium_impact	1.51	medium_impact	0.65	0.8	26.53	11.6	0.34	N	0.73	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10615	10615	T	C	MI.15996	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	146	49	L	P	cTc/cCc	-0.4	0	0	probably_damaging	0.93	neutral	0.17	neutral	1.79	deleterious	-4.03	deleterious	-6	medium_impact	2.82	0.63	neutral	0.27	damaging	3.80	23.40	deleterious	0.33	0.5	0.89	disease	0.87	disease	0.67	disease	0.79	disease	6	0.96	neutral	0.12	neutral	1	deleterious	0.81	deleterious	-1.83	low_impact	-0.17	medium_impact	1.23	medium_impact	0.59	0.8	26.53	11.6	0.27	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10615	10615	T	A	MI.15997	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	146	49	L	H	cTc/cAc	-0.4	0	0	probably_damaging	0.96	neutral	0.43	neutral	1.79	deleterious	-3.5	deleterious	-5.94	medium_impact	1.99	0.81	neutral	0.36	neutral	4.06	23.70	deleterious	0.3	0.45	0.9	disease	0.8	disease	0.48	neutral	0.75	disease	5	0.96	neutral	0.24	neutral	1	deleterious	0.81	deleterious	-2.07	low_impact	0.14	medium_impact	0.53	medium_impact	0.49	0.8	26.53	11.6	0.24	N	0.84	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10617	10617	A	C	MI.15998	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	148	50	N	H	Aac/Cac	-6.16	0	0	probably_damaging	1	neutral	0.53	neutral	1.94	neutral	-1.49	deleterious	-3.93	neutral_impact	0.54	0.77	neutral	0.92	neutral	1.70	14.40	neutral	0.71	0.75	0.28	neutral	0.73	disease	0.35	neutral	0.57	disease	1	0.99	deleterious	0.27	neutral	-2	neutral	0.69	deleterious	-3.55	low_impact	0.24	medium_impact	-0.69	medium_impact	0.52	0.8	23.47	11.07	0.25	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10617	10617	A	G	MI.15999	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	148	50	N	D	Aac/Gac	-6.16	0	0	probably_damaging	0.96	neutral	0.21	neutral	1.95	neutral	-0.92	deleterious	-3.81	medium_impact	2.8	0.81	neutral	0.6	neutral	0.90	10.06	neutral	0.8	0.85	0.29	neutral	0.78	disease	0.52	disease	0.59	disease	2	0.97	neutral	0.13	neutral	1	deleterious	0.72	deleterious	-2.07	low_impact	-0.11	medium_impact	1.21	medium_impact	0.48	0.8	23.47	11.07	0.36	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8533	8533	G	A	MI.16	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	7	3	E	K	Gaa/Aaa	-0.1	0.06	0	probably_damaging	0.95	neutral	0.35	neutral	4.69	neutral	-0.16	neutral	-1.47	low_impact	0.92	0.89	neutral	0.57	neutral	2.08	16.72	deleterious	0.65	0.7	0.39	neutral	0.26	neutral	0.25	neutral	0.46	neutral	1	0.96	neutral	0.2	neutral	-2	neutral	0.64	deleterious	-1.97	low_impact	0.14	medium_impact	-0.31	medium_impact	0.75	0.9	15.93	14.48	0.44	N	1.00	polymorphism	0.99	0.02	rs386829039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8600	8600	T	A	MI.160	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	74	25	L	Q	cTa/cAa	-2.19	0	0	probably_damaging	1	deleterious	0.03	neutral	4.13	deleterious	-3.66	deleterious	-3.02	medium_impact	3	0.82	neutral	0.5	neutral	3.81	23.40	deleterious	0.21	0.65	0.85	disease	0.46	neutral	0.57	disease	0.63	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-3.6	low_impact	-0.56	medium_impact	1.47	medium_impact	0.59	0.9	10.18	13.06	0.37	N	0.71	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8439	8439	A	G	MI.1600	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	74	25	Q	R	cAa/cGa	3.37	0.56	0	probably_damaging	0.94	neutral	0.35	neutral	1.58	deleterious	-4.61	deleterious	-3.99	high_impact	3.86	0.98	neutral	0.34	neutral	3.33	22.90	deleterious	0.41328743	0.85	0.64	disease	0.54	disease	0.79	disease	0.69	disease	4	0.94	neutral	0.21	neutral	2	deleterious	0.79	deleterious	-1.89	low_impact	0.14	medium_impact	2.21	high_impact	0.54	0.85	5.88	7.45	0.58	P	0.77	polymorphism	0.93	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10617	10617	A	T	MI.16000	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	148	50	N	Y	Aac/Tac	-6.16	0	0	probably_damaging	1	neutral	1	neutral	1.97	neutral	-1.55	deleterious	-6.56	low_impact	1.52	0.81	neutral	0.2	damaging	3.71	23.30	deleterious	0.58	0.65	0.6	disease	0.85	disease	0.45	neutral	0.76	disease	5	0.99	deleterious	0.5	deleterious	-2	neutral	0.78	deleterious	-3.55	low_impact	1.88	high_impact	0.14	medium_impact	0.37	0.8	23.47	11.07	0.18	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10618	10618	A	C	MI.16001	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	149	50	N	T	aAc/aCc	0.75	0	0	probably_damaging	0.94	neutral	0.39	neutral	1.97	neutral	-0.91	deleterious	-4.56	low_impact	1.52	0.78	neutral	0.95	neutral	2.06	16.63	deleterious	0.67	0.7	0.32	neutral	0.64	disease	0.3	neutral	0.47	neutral	1	0.94	neutral	0.23	neutral	-2	neutral	0.69	deleterious	-1.9	low_impact	0.1	medium_impact	0.14	medium_impact	0.43	0.8	23.47	11.07	0.32	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10618	10618	A	T	MI.16002	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	149	50	N	I	aAc/aTc	0.75	0	0	probably_damaging	0.99	neutral	0.43	neutral	1.96	neutral	-2.34	deleterious	-7.47	medium_impact	2.02	0.78	neutral	0.43	neutral	3.93	23.50	deleterious	0.57	0.65	0.55	disease	0.88	disease	0.47	neutral	0.73	disease	5	0.99	deleterious	0.22	neutral	1	deleterious	0.79	deleterious	-2.63	low_impact	0.14	medium_impact	0.56	medium_impact	0.30	0.8	23.47	11.07	0.26	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10618	10618	A	G	MI.16003	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	149	50	N	S	aAc/aGc	0.75	0	0	possibly_damaging	0.52	neutral	0.44	neutral	2.01	neutral	-0.54	deleterious	-3.71	low_impact	0.88	0.75	neutral	0.95	neutral	0.14	4.03	deleterious	0.84	0.85	0.18	neutral	0.63	disease	0.34	neutral	0.44	neutral	1	0.56	neutral	0.46	neutral	-3	neutral	0.67	deleterious	-0.84	medium_impact	0.15	medium_impact	-0.4	medium_impact	0.20	0.8	23.47	11.07	0.35	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10619	10619	C	A	MI.16004	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	150	50	N	K	aaC/aaA	-0.4	0	0	probably_damaging	0.94	neutral	0.29	neutral	2	neutral	-0.28	deleterious	-4.87	medium_impact	2.25	0.79	neutral	0.28	neutral	3.10	22.50	deleterious	0.85	0.85	0.19	neutral	0.85	disease	0.49	neutral	0.6	disease	2	0.95	neutral	0.18	neutral	1	deleterious	0.74	deleterious	-1.9	low_impact	-0.01	medium_impact	0.75	medium_impact	0.55	0.8	23.47	11.07	0.29	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10619	10619	C	G	MI.16005	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	150	50	N	K	aaC/aaG	-0.4	0	0	probably_damaging	0.94	neutral	0.29	neutral	2	neutral	-0.28	deleterious	-4.87	medium_impact	2.25	0.79	neutral	0.28	neutral	2.66	20.60	deleterious	0.85	0.85	0.19	neutral	0.85	disease	0.49	neutral	0.6	disease	2	0.95	neutral	0.18	neutral	1	deleterious	0.74	deleterious	-1.9	low_impact	-0.01	medium_impact	0.75	medium_impact	0.55	0.8	23.47	11.07	0.29	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10620	10620	A	T	MI.16006	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	151	51	T	S	Acc/Tcc	-5.01	0	0	benign	0.18	neutral	0.51	neutral	1.84	neutral	-1.41	neutral	0.24	neutral_impact	-0.35	0.82	neutral	1	neutral	-0.52	0.20	neutral	0.65	0.7	0.11	neutral	0.21	neutral	0.31	neutral	0.35	neutral	3	0.39	neutral	0.67	deleterious	-6	neutral	0.14	neutral	-0.2	medium_impact	0.22	medium_impact	-1.43	low_impact	0.58	0.8	28.57	17.13	0.31	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10620	10620	A	C	MI.16007	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	151	51	T	P	Acc/Ccc	-5.01	0	0	possibly_damaging	0.55	neutral	0.22	neutral	1.77	deleterious	-3.21	neutral	-2.03	medium_impact	2.02	0.79	neutral	0.67	neutral	1.81	15.05	deleterious	0.3	0.45	0.37	neutral	0.77	disease	0.63	disease	0.77	disease	5	0.77	neutral	0.34	neutral	0	NA	0.44	deleterious	-0.88	medium_impact	-0.1	medium_impact	0.56	medium_impact	0.57	0.8	28.57	17.13	0.3	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10620	10620	A	G	MI.16008	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	151	51	T	A	Acc/Gcc	-5.01	0	0	benign	0.01	neutral	0.53	neutral	1.83	neutral	-1.54	neutral	-0.6	low_impact	1.26	0.83	neutral	0.93	neutral	-0.44	0.32	neutral	0.77	0.8	0.15	neutral	0.27	neutral	0.46	neutral	0.43	neutral	1	0.45	neutral	0.76	deleterious	-6	neutral	0.09	neutral	1.03	medium_impact	0.24	medium_impact	-0.08	medium_impact	0.38	0.8	28.57	17.13	0.29	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10621	10621	C	T	MI.16009	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	152	51	T	I	aCc/aTc	-1.78	0	0	benign	0.01	neutral	0.41	neutral	1.8	neutral	-2.26	neutral	-0.23	low_impact	1.32	0.81	neutral	0.92	neutral	0.31	5.74	deleterious	0.62	0.65	0.21	neutral	0.51	disease	0.38	neutral	0.45	neutral	1	0.58	neutral	0.7	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.12	medium_impact	-0.03	medium_impact	0.60	0.8	28.57	17.13	0.37	N	0.85	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8439	8439	A	C	MI.1601	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	74	25	Q	P	cAa/cCa	3.37	0.56	0	probably_damaging	0.96	neutral	0.21	neutral	1.58	deleterious	-6.33	deleterious	-5.99	medium_impact	2.44	0.97	neutral	0.24	damaging	3.13	22.60	deleterious	0.22453471	0.85	0.83	disease	0.65	disease	0.78	disease	0.66	disease	3	0.97	neutral	0.13	neutral	1	deleterious	0.85	deleterious	-2.07	low_impact	-0.03	medium_impact	0.99	medium_impact	0.49	0.85	5.88	7.45	0.51	N	0.90	disease_causing	0.58	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10621	10621	C	A	MI.16010	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	152	51	T	N	aCc/aAc	-1.78	0	0	possibly_damaging	0.62	neutral	0.38	neutral	1.8	neutral	-2.17	neutral	-0.89	low_impact	0.89	0.81	neutral	0.98	neutral	1.71	14.44	neutral	0.68	0.7	0.13	neutral	0.34	neutral	0.35	neutral	0.43	neutral	1	0.67	neutral	0.38	neutral	-3	neutral	0.36	neutral	-1	medium_impact	0.09	medium_impact	-0.39	medium_impact	0.75	0.85	28.57	17.13	0.37	N	0.07	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10621	10621	C	G	MI.16011	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	152	51	T	S	aCc/aGc	-1.78	0	0	benign	0.18	neutral	0.51	neutral	1.84	neutral	-1.41	neutral	0.24	neutral_impact	-0.35	0.82	neutral	1	neutral	-0.12	1.55	neutral	0.65	0.7	0.11	neutral	0.21	neutral	0.31	neutral	0.35	neutral	3	0.39	neutral	0.67	deleterious	-6	neutral	0.14	neutral	-0.2	medium_impact	0.22	medium_impact	-1.43	low_impact	0.58	0.8	28.57	17.13	0.32	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10623	10623	C	G	MI.16012	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	154	52	H	D	Cac/Gac	-6.16	0	0	possibly_damaging	0.83	neutral	0.23	neutral	2.06	neutral	-0.36	deleterious	-5.56	low_impact	1.13	0.82	neutral	0.62	neutral	2.47	19.30	deleterious	0.5	0.6	0.18	neutral	0.55	disease	0.55	disease	0.44	neutral	1	0.89	neutral	0.2	neutral	-3	neutral	0.66	deleterious	-1.43	low_impact	-0.08	medium_impact	-0.19	medium_impact	0.56	0.8	36.73	8.63	0.32	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10623	10623	C	A	MI.16013	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	154	52	H	N	Cac/Aac	-6.16	0	0	benign	0.12	neutral	0.34	neutral	2.03	neutral	-0.23	deleterious	-3.48	neutral_impact	-0.23	0.79	neutral	0.94	neutral	2.42	18.95	deleterious	0.79	0.8	0.12	neutral	0.35	neutral	0.37	neutral	0.44	neutral	1	0.61	neutral	0.61	deleterious	-6	neutral	0.57	deleterious	-0.01	medium_impact	0.05	medium_impact	-1.33	low_impact	0.63	0.8	36.73	8.63	0.31	N	0.29	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10623	10623	C	T	MI.16014	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	154	52	H	Y	Cac/Tac	-6.16	0	0	probably_damaging	0.95	neutral	1	neutral	1.95	neutral	-2.56	deleterious	-4.06	low_impact	1.62	0.83	neutral	0.46	neutral	1.85	15.28	deleterious	0.75	0.8	0.38	neutral	0.58	disease	0.49	neutral	0.54	disease	1	0.95	neutral	0.53	deleterious	-2	neutral	0.70	deleterious	-1.97	low_impact	1.88	high_impact	0.22	medium_impact	0.42	0.8	36.73	8.63	0.19	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10624	10624	A	C	MI.16015	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	155	52	H	P	cAc/cCc	1.21	0.21	0	probably_damaging	0.98	neutral	0.22	neutral	1.96	neutral	-2.1	deleterious	-6.78	low_impact	1.32	0.74	neutral	0.64	neutral	3.19	22.70	deleterious	0.4	0.5	0.33	neutral	0.85	disease	0.65	disease	0.63	disease	3	0.98	deleterious	0.12	neutral	-2	neutral	0.77	deleterious	-2.35	low_impact	-0.1	medium_impact	-0.03	medium_impact	0.43	0.8	36.73	8.63	0.32	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10624	10624	A	G	MI.16016	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	155	52	H	R	cAc/cGc	1.21	0.21	0	benign	0.17	neutral	0.36	neutral	1.99	neutral	-0.41	deleterious	-5.02	medium_impact	2.12	0.84	neutral	0.38	neutral	1.10	11.21	neutral	0.79	0.8	0.17	neutral	0.66	disease	0.47	neutral	0.55	disease	1	0.57	neutral	0.6	deleterious	-3	neutral	0.21	neutral	-0.17	medium_impact	0.07	medium_impact	0.64	medium_impact	0.46	0.8	36.73	8.63	0.32	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10624	10624	A	T	MI.16017	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	155	52	H	L	cAc/cTc	1.21	0.21	0	possibly_damaging	0.83	neutral	0.67	neutral	2	neutral	-1.13	deleterious	-7.26	low_impact	1.46	0.73	neutral	0.72	neutral	3.61	23.20	deleterious	0.53	0.6	0.23	neutral	0.67	disease	0.46	neutral	0.48	neutral	0	0.8	neutral	0.42	neutral	-3	neutral	0.65	deleterious	-1.43	low_impact	0.38	medium_impact	0.09	medium_impact	0.35	0.8	36.73	8.63	0.33	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10625	10625	C	G	MI.16018	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	156	52	H	Q	caC/caG	3.52	0.26	0	possibly_damaging	0.89	neutral	0.32	neutral	2.02	neutral	-0.06	deleterious	-4.66	neutral_impact	0.69	0.79	neutral	0.78	neutral	-0.10	1.73	neutral	0.92	0.95	0.12	neutral	0.33	neutral	0.35	neutral	0.44	neutral	1	0.9	neutral	0.22	neutral	-3	neutral	0.60	deleterious	-1.64	low_impact	0.03	medium_impact	-0.56	medium_impact	0.64	0.8	36.73	8.63	0.35	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10625	10625	C	A	MI.16019	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	156	52	H	Q	caC/caA	3.52	0.26	0	possibly_damaging	0.89	neutral	0.32	neutral	2.02	neutral	-0.06	deleterious	-4.66	neutral_impact	0.69	0.79	neutral	0.78	neutral	0.12	3.84	deleterious	0.92	0.95	0.12	neutral	0.33	neutral	0.35	neutral	0.44	neutral	1	0.9	neutral	0.22	neutral	-3	neutral	0.60	deleterious	-1.64	low_impact	0.03	medium_impact	-0.56	medium_impact	0.64	0.8	36.73	8.63	0.35	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8440	8440	A	T	MI.1602	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	75	25	Q	H	caA/caT	2.21	0.54	0.01	probably_damaging	0.99	neutral	0.54	neutral	1.57	deleterious	-6.23	deleterious	-4.99	high_impact	3.86	0.98	neutral	0.32	neutral	3.45	23.00	deleterious	0.41328743	0.85	0.83	disease	0.5	neutral	0.76	disease	0.67	disease	3	0.99	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-2.65	low_impact	0.33	medium_impact	2.21	high_impact	0.63	0.85	5.88	7.45	0.48	N	0.82	polymorphism	0.89	0.35	rs386829036	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10626	10626	T	A	MI.16020	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	157	53	S	T	Tcc/Acc	-2.01	0	0	benign	0.02	neutral	0.41	neutral	1.93	neutral	-0.91	neutral	-0.57	low_impact	1.55	0.82	neutral	0.86	neutral	0.36	6.29	deleterious	0.51	0.6	0.19	neutral	0.23	neutral	0.26	neutral	0.44	neutral	1	0.57	neutral	0.7	deleterious	-6	neutral	0.11	neutral	0.75	medium_impact	0.12	medium_impact	0.16	medium_impact	0.56	0.8	33.67	16.38	0.42	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10626	10626	T	G	MI.16021	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	157	53	S	A	Tcc/Gcc	-2.01	0	0	benign	0.18	neutral	0.54	neutral	1.93	neutral	-0.97	neutral	-0.62	low_impact	1.82	0.75	neutral	0.85	neutral	-0.21	1.03	neutral	0.67	0.7	0.22	neutral	0.28	neutral	0.43	neutral	0.44	neutral	1	0.35	neutral	0.68	deleterious	-6	neutral	0.16	neutral	-0.2	medium_impact	0.25	medium_impact	0.39	medium_impact	0.55	0.8	33.67	16.38	0.35	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10626	10626	T	C	MI.16022	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	157	53	S	P	Tcc/Ccc	-2.01	0	0	possibly_damaging	0.62	neutral	0.21	neutral	1.88	neutral	-2.49	neutral	-2.31	medium_impact	2.35	0.74	neutral	0.55	neutral	2.45	19.15	deleterious	0.47	0.55	0.49	neutral	0.87	disease	0.62	disease	0.76	disease	5	0.8	neutral	0.3	neutral	0	NA	0.64	deleterious	-1	medium_impact	-0.11	medium_impact	0.83	medium_impact	0.53	0.8	33.67	16.38	0.31	N	0.64	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10627	10627	C	T	MI.16023	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	158	53	S	F	tCc/tTc	-0.63	0	0	benign	0.01	neutral	0.71	neutral	1.9	neutral	-1.72	neutral	3.19	neutral_impact	0.66	0.9	neutral	0.98	neutral	-0.21	1.05	neutral	0.42	0.55	0.2	neutral	0.6	disease	0.35	neutral	0.45	neutral	1	0.28	neutral	0.85	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.43	medium_impact	-0.59	medium_impact	0.31	0.8	33.67	16.38	0.25	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10627	10627	C	A	MI.16024	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	158	53	S	Y	tCc/tAc	-0.63	0	0	benign	0.26	neutral	1	neutral	1.91	neutral	-1.44	neutral	2.27	low_impact	1.38	0.84	neutral	0.9	neutral	-0.34	0.54	neutral	0.39	0.5	0.4	neutral	0.73	disease	0.31	neutral	0.56	disease	1	0.26	neutral	0.87	deleterious	-6	neutral	0.29	neutral	-0.39	medium_impact	1.88	high_impact	0.02	medium_impact	0.62	0.8	33.67	16.38	0.2	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10627	10627	C	G	MI.16025	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	158	53	S	C	tCc/tGc	-0.63	0	0	possibly_damaging	0.89	neutral	0.18	neutral	1.87	deleterious	-3.13	neutral	-1.13	medium_impact	2.52	0.72	neutral	0.41	neutral	0.42	6.79	deleterious	0.47	0.55	0.54	disease	0.68	disease	0.36	neutral	0.52	disease	0	0.94	neutral	0.15	neutral	0	NA	0.65	deleterious	-1.64	low_impact	-0.16	medium_impact	0.97	medium_impact	0.54	0.8	33.67	16.38	0.42	N	0.43	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10629	10629	C	A	MI.16026	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	160	54	L	I	Ctc/Atc	-6.63	0	0	benign	0.07	neutral	0.4	neutral	1.96	neutral	-0.57	neutral	0.04	neutral_impact	0.31	0.82	neutral	0.97	neutral	1.17	11.59	neutral	0.64	0.7	0.19	neutral	0.3	neutral	0.2	neutral	0.44	neutral	1	0.55	neutral	0.67	deleterious	-6	neutral	0.16	neutral	0.23	medium_impact	0.11	medium_impact	-0.88	medium_impact	0.61	0.8	33.67	23.2	0.43	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10629	10629	C	G	MI.16027	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	160	54	L	V	Ctc/Gtc	-6.63	0	0	benign	0.01	neutral	0.51	neutral	1.96	neutral	-0.6	neutral	0.34	low_impact	1.34	0.82	neutral	0.9	neutral	0.44	6.93	deleterious	0.65	0.7	0.16	neutral	0.31	neutral	0.23	neutral	0.45	neutral	1	0.48	neutral	0.75	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	0.22	medium_impact	-0.02	medium_impact	0.46	0.8	33.67	23.2	0.35	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10629	10629	C	T	MI.16028	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	160	54	L	F	Ctc/Ttc	-6.63	0	0	benign	0.34	neutral	0.71	neutral	1.91	neutral	-1.51	neutral	-1.1	neutral_impact	0.22	0.8	neutral	0.97	neutral	2.33	18.35	deleterious	0.61	0.65	0.3	neutral	0.36	neutral	0.4	neutral	0.44	neutral	1	0.25	neutral	0.69	deleterious	-6	neutral	0.43	deleterious	-0.54	medium_impact	0.43	medium_impact	-0.95	medium_impact	0.48	0.8	33.67	23.2	0.28	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10630	10630	T	C	MI.16029	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	161	54	L	P	cTc/cCc	-2.24	0	0	benign	0	neutral	0.22	neutral	2.23	neutral	1.55	neutral	-0.86	neutral_impact	0.01	0.87	neutral	0.87	neutral	0.31	5.79	deleterious	0.37	0.5	0.23	neutral	0.71	disease	0.44	neutral	0.56	disease	1	0.78	neutral	0.61	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	-0.1	medium_impact	-1.13	low_impact	0.41	0.8	33.67	23.2	0.33	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8440	8440	A	C	MI.1603	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	75	25	Q	H	caA/caC	2.21	0.54	0.01	probably_damaging	0.99	neutral	0.54	neutral	1.57	deleterious	-6.23	deleterious	-4.99	high_impact	3.86	0.98	neutral	0.32	neutral	3.32	22.90	deleterious	0.41328743	0.85	0.83	disease	0.5	neutral	0.76	disease	0.67	disease	3	0.99	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-2.65	low_impact	0.33	medium_impact	2.21	high_impact	0.63	0.85	5.88	7.45	0.48	N	0.82	polymorphism	0.89	0.35	rs386829036	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10630	10630	T	A	MI.16030	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	161	54	L	H	cTc/cAc	-2.24	0	0	possibly_damaging	0.68	neutral	0.53	neutral	1.89	neutral	-2.42	neutral	-1.98	low_impact	1.8	0.83	neutral	0.6	neutral	2.79	21.30	deleterious	0.44	0.55	0.36	neutral	0.6	disease	0.45	neutral	0.55	disease	1	0.65	neutral	0.43	neutral	-3	neutral	0.58	deleterious	-1.1	low_impact	0.24	medium_impact	0.37	medium_impact	0.46	0.8	33.67	23.2	0.25	N	0.41	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10630	10630	T	G	MI.16031	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	161	54	L	R	cTc/cGc	-2.24	0	0	benign	0.23	neutral	0.34	neutral	1.91	neutral	-1.64	neutral	-1.41	medium_impact	2.15	0.79	neutral	0.51	neutral	1.47	13.14	neutral	0.41	0.5	0.24	neutral	0.81	disease	0.5	neutral	0.76	disease	5	0.59	neutral	0.56	deleterious	-3	neutral	0.38	neutral	-0.32	medium_impact	0.05	medium_impact	0.66	medium_impact	0.49	0.8	33.67	23.2	0.3	N	0.34	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10632	10632	T	A	MI.16032	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	163	55	L	M	Tta/Ata	-10.08	0	0	possibly_damaging	0.76	neutral	0.22	neutral	1.62	deleterious	-3.4	neutral	-1.05	low_impact	0.96	0.77	neutral	0.94	neutral	2.19	17.47	deleterious	0.44	0.55	0.45	neutral	0.22	neutral	0.23	neutral	0.41	neutral	2	0.85	neutral	0.23	neutral	-3	neutral	0.66	deleterious	-1.26	low_impact	-0.1	medium_impact	-0.33	medium_impact	0.63	0.8	31.63	14.43	0.46	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10632	10632	T	G	MI.16033	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	163	55	L	V	Tta/Gta	-10.08	0	0	possibly_damaging	0.9	neutral	0.5	neutral	1.72	neutral	-1.7	neutral	-1.6	low_impact	1.34	0.77	neutral	0.88	neutral	1.62	13.94	neutral	0.58	0.65	0.28	neutral	0.31	neutral	0.39	neutral	0.45	neutral	1	0.89	neutral	0.3	neutral	-3	neutral	0.65	deleterious	-1.68	low_impact	0.21	medium_impact	-0.02	medium_impact	0.30	0.8	31.63	14.43	0.34	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10633	10633	T	C	MI.16034	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	164	55	L	S	tTa/tCa	-2.71	0	0	probably_damaging	0.98	neutral	0.42	neutral	1.72	neutral	-1.71	deleterious	-3.86	neutral_impact	-0.05	0.76	neutral	0.97	neutral	1.49	13.27	neutral	0.38	0.5	0.19	neutral	0.14	neutral	0.3	neutral	0.28	neutral	4	0.98	deleterious	0.22	neutral	-2	neutral	0.64	deleterious	-2.35	low_impact	0.13	medium_impact	-1.18	low_impact	0.41	0.8	31.63	14.43	0.35	N	0.18	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10633	10633	T	G	MI.16035	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	164	55	L	W	tTa/tGa	-2.71	0	0	probably_damaging	1	neutral	0.18	neutral	1.58	deleterious	-6.1	deleterious	-4.78	medium_impact	2.34	0.79	neutral	0.08	damaging	2.52	19.58	deleterious	0.27	0.45	0.75	disease	0.6	disease	0.48	neutral	0.5	neutral	0	1	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	-0.16	medium_impact	0.82	medium_impact	0.49	0.8	31.63	14.43	0.25	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10634	10634	A	T	MI.16036	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	165	55	L	F	ttA/ttT	-0.17	0	0	probably_damaging	0.98	neutral	0.7	neutral	1.64	neutral	-2.96	deleterious	-2.95	low_impact	1.72	0.78	neutral	0.24	damaging	1.55	13.56	neutral	0.5	0.6	0.43	neutral	0.4	neutral	0.39	neutral	0.45	neutral	1	0.98	neutral	0.36	neutral	-2	neutral	0.68	deleterious	-2.35	low_impact	0.41	medium_impact	0.3	medium_impact	0.35	0.8	31.63	14.43	0.24	N	0.46	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10634	10634	A	C	MI.16037	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	165	55	L	F	ttA/ttC	-0.17	0	0	probably_damaging	0.98	neutral	0.7	neutral	1.64	neutral	-2.96	deleterious	-2.95	low_impact	1.72	0.78	neutral	0.24	damaging	1.44	13.01	neutral	0.5	0.6	0.43	neutral	0.4	neutral	0.39	neutral	0.45	neutral	1	0.98	neutral	0.36	neutral	-2	neutral	0.68	deleterious	-2.35	low_impact	0.41	medium_impact	0.3	medium_impact	0.35	0.8	31.63	14.43	0.21	N	0.46	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10635	10635	G	A	MI.16038	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	166	56	A	T	Gcc/Acc	-2.71	0	0	benign	0.01	neutral	0.38	neutral	1.98	neutral	-0.28	neutral	-0.21	neutral_impact	0.04	0.85	neutral	0.98	neutral	0.67	8.61	deleterious	0.63	0.7	0.25	neutral	0.29	neutral	0.18	neutral	0.44	neutral	1	0.61	neutral	0.69	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.09	medium_impact	-1.1	low_impact	0.47	0.8	31.63	17.2	0.52	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10635	10635	G	T	MI.16039	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	166	56	A	S	Gcc/Tcc	-2.71	0	0	benign	0.01	neutral	0.49	neutral	1.99	neutral	-0.12	neutral	0.66	neutral_impact	-0.26	0.8	neutral	0.93	neutral	-0.25	0.84	neutral	0.65	0.7	0.13	neutral	0.22	neutral	0.18	neutral	0.39	neutral	2	0.5	neutral	0.74	deleterious	-6	neutral	0.23	neutral	1.03	medium_impact	0.2	medium_impact	-1.36	low_impact	0.77	0.85	31.63	17.2	0.41	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8441	8441	C	A	MI.1604	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	76	26	L	M	Cta/Ata	-0.8	0	0	probably_damaging	1	neutral	0.35	neutral	1.1	deleterious	-5.36	neutral	-1.99	medium_impact	2.64	0.99	neutral	0.5	neutral	3.79	23.40	deleterious	0.48904297	0.85	0.63	disease	0.35	neutral	0.53	disease	0.26	neutral	5	1	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.14	medium_impact	1.17	medium_impact	0.86	0.90	1.47	7.57	0.51	N	0.61	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10635	10635	G	C	MI.16040	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	166	56	A	P	Gcc/Ccc	-2.71	0	0	benign	0.42	neutral	0.19	neutral	2.15	neutral	1.42	neutral	-2.31	low_impact	1.79	0.76	neutral	0.65	neutral	2.23	17.73	deleterious	0.35	0.5	0.45	neutral	0.76	disease	0.51	disease	0.59	disease	2	0.78	neutral	0.39	neutral	-6	neutral	0.62	deleterious	-0.68	medium_impact	-0.14	medium_impact	0.36	medium_impact	0.79	0.85	31.63	17.2	0.35	N	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10636	10636	C	T	MI.16041	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	167	56	A	V	gCc/gTc	-0.63	0	0	benign	0.01	neutral	0.5	neutral	2.06	neutral	0.74	neutral	-1.46	low_impact	1.25	0.82	neutral	0.67	neutral	0.96	10.43	neutral	0.55	0.6	0.26	neutral	0.44	neutral	0.35	neutral	0.47	neutral	1	0.49	neutral	0.75	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.21	medium_impact	-0.09	medium_impact	0.57	0.8	31.63	17.2	0.33	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10636	10636	C	A	MI.16042	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	167	56	A	D	gCc/gAc	-0.63	0	0	benign	0.34	neutral	0.2	neutral	1.95	neutral	-1.11	neutral	-2.23	low_impact	1.28	0.8	neutral	0.36	neutral	3.02	22.30	deleterious	0.42	0.5	0.3	neutral	0.74	disease	0.44	neutral	0.53	disease	1	0.76	neutral	0.43	neutral	-6	neutral	0.52	deleterious	-0.54	medium_impact	-0.12	medium_impact	-0.07	medium_impact	0.63	0.8	31.63	17.2	0.29	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10636	10636	C	G	MI.16043	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	167	56	A	G	gCc/gGc	-0.63	0	0	benign	0.12	neutral	0.4	neutral	2.05	neutral	0.67	neutral	-2	low_impact	0.86	0.84	neutral	0.68	neutral	0.93	10.25	neutral	0.61	0.65	0.36	neutral	0.46	neutral	0.35	neutral	0.49	neutral	0	0.54	neutral	0.64	deleterious	-6	neutral	0.35	neutral	-0.01	medium_impact	0.11	medium_impact	-0.42	medium_impact	0.78	0.85	31.63	17.2	0.32	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10638	10638	A	C	MI.16044	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	169	57	N	H	Aat/Cat	-12.16	0	0	possibly_damaging	0.69	neutral	0.54	neutral	1.99	neutral	-0.23	neutral	0.35	medium_impact	2.16	0.85	neutral	0.64	neutral	1.80	14.97	neutral	0.75	0.8	0.36	neutral	0.52	disease	0.6	disease	0.73	disease	5	0.66	neutral	0.43	neutral	0	NA	0.61	deleterious	-1.12	low_impact	0.25	medium_impact	0.67	medium_impact	0.57	0.8	33.67	21.76	0.27	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10638	10638	A	G	MI.16045	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	169	57	N	D	Aat/Gat	-12.16	0	0	possibly_damaging	0.54	neutral	0.21	neutral	1.99	neutral	-0.24	neutral	-1.09	medium_impact	2.16	0.83	neutral	0.47	neutral	2.69	20.80	deleterious	0.75	0.8	0.24	neutral	0.55	disease	0.59	disease	0.73	disease	5	0.78	neutral	0.34	neutral	0	NA	0.62	deleterious	-0.87	medium_impact	-0.11	medium_impact	0.67	medium_impact	0.55	0.8	33.67	21.76	0.37	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10638	10638	A	T	MI.16046	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	169	57	N	Y	Aat/Tat	-12.16	0	0	benign	0.02	neutral	1	neutral	2.01	neutral	0.34	neutral	2.25	neutral_impact	-0.06	0.85	neutral	0.95	neutral	0.25	5.25	deleterious	0.58	0.65	0.41	neutral	0.55	disease	0.46	neutral	0.46	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	1.88	high_impact	-1.19	low_impact	0.42	0.8	33.67	21.76	0.2	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10639	10639	A	C	MI.16047	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	170	57	N	T	aAt/aCt	-0.63	0	0	benign	0.05	neutral	0.4	neutral	2.02	neutral	0.59	neutral	0.14	neutral_impact	0.55	0.86	neutral	0.98	neutral	1.70	14.39	neutral	0.7	0.75	0.11	neutral	0.23	neutral	0.45	neutral	0.42	neutral	2	0.57	neutral	0.68	deleterious	-6	neutral	0.54	deleterious	0.37	medium_impact	0.11	medium_impact	-0.68	medium_impact	0.58	0.8	33.67	21.76	0.34	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10639	10639	A	G	MI.16048	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	170	57	N	S	aAt/aGt	-0.63	0	0	benign	0.27	neutral	0.41	neutral	2.08	neutral	1.45	neutral	0.33	neutral_impact	-0.98	0.92	neutral	0.99	neutral	0.41	6.74	deleterious	0.74	0.8	0.16	neutral	0.11	neutral	0.48	neutral	0.32	neutral	4	0.5	neutral	0.57	deleterious	-6	neutral	0.48	deleterious	-0.41	medium_impact	0.12	medium_impact	-1.96	low_impact	0.34	0.8	33.67	21.76	0.38	N	0.02	polymorphism	1	0.01	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10639	10639	A	T	MI.16049	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	170	57	N	I	aAt/aTt	-0.63	0	0	benign	0.37	neutral	0.4	neutral	2.01	neutral	0.17	neutral	0.02	neutral_impact	0.26	0.87	neutral	0.94	neutral	2.79	21.30	deleterious	0.58	0.65	0.29	neutral	0.66	disease	0.47	neutral	0.54	disease	1	0.53	neutral	0.52	deleterious	-6	neutral	0.60	deleterious	-0.59	medium_impact	0.11	medium_impact	-0.92	medium_impact	0.36	0.8	33.67	21.76	0.31	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8441	8441	C	G	MI.1605	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	76	26	L	V	Cta/Gta	-0.8	0	0	probably_damaging	0.97	neutral	0.47	neutral	1.25	deleterious	-4.54	deleterious	-3	medium_impact	3.34	0.99	neutral	0.14	damaging	3.25	22.80	deleterious	0.57564883	0.85	0.55	disease	0.27	neutral	0.65	disease	0.17	neutral	7	0.97	neutral	0.25	neutral	1	deleterious	0.77	deleterious	-2.19	low_impact	0.26	medium_impact	1.77	medium_impact	0.70	0.85	1.47	7.57	0.45	N	0.46	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10640	10640	T	G	MI.16050	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	171	57	N	K	aaT/aaG	-0.63	0	0	possibly_damaging	0.46	neutral	0.3	neutral	2.02	neutral	0.63	neutral	-0.87	low_impact	1.81	0.83	neutral	0.48	neutral	2.84	21.60	deleterious	0.75	0.8	0.16	neutral	0.63	disease	0.6	disease	0.75	disease	5	0.66	neutral	0.42	neutral	-3	neutral	0.60	deleterious	-0.74	medium_impact	0.01	medium_impact	0.38	medium_impact	0.61	0.8	33.67	21.76	0.31	N	0.63	polymorphism	1	0.01	rs386419955	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10640	10640	T	A	MI.16051	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	171	57	N	K	aaT/aaA	-0.63	0	0	possibly_damaging	0.46	neutral	0.3	neutral	2.02	neutral	0.63	neutral	-0.87	low_impact	1.81	0.83	neutral	0.48	neutral	3.16	22.60	deleterious	0.75	0.8	0.16	neutral	0.63	disease	0.6	disease	0.75	disease	5	0.66	neutral	0.42	neutral	-3	neutral	0.60	deleterious	-0.74	medium_impact	0.01	medium_impact	0.38	medium_impact	0.61	0.8	33.67	21.76	0.31	N	0.63	polymorphism	1	0.01	rs386419955	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10641	10641	A	T	MI.16052	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	172	58	I	F	Att/Ttt	-7.55	0	0	possibly_damaging	0.69	neutral	0.81	neutral	1.91	neutral	-1.39	neutral	-1.74	low_impact	0.82	0.81	neutral	0.54	neutral	2.16	17.22	deleterious	0.56	0.6	0.25	neutral	0.55	disease	0.5	neutral	0.53	disease	1	0.63	neutral	0.56	deleterious	-3	neutral	0.60	deleterious	-1.12	low_impact	0.56	medium_impact	-0.45	medium_impact	0.71	0.85	31.63	19.86	0.23	N	0.43	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10641	10641	A	G	MI.16053	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	172	58	I	V	Att/Gtt	-7.55	0	0	possibly_damaging	0.44	neutral	0.58	neutral	2.03	neutral	0.27	neutral	-0.02	low_impact	1.32	0.85	neutral	0.94	neutral	-0.92	0.02	neutral	0.71	0.75	0.13	neutral	0.2	neutral	0.39	neutral	0.36	neutral	3	0.4	neutral	0.57	deleterious	-3	neutral	0.28	neutral	-0.71	medium_impact	0.29	medium_impact	-0.03	medium_impact	0.71	0.85	31.63	19.86	0.3	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10641	10641	A	C	MI.16054	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	172	58	I	L	Att/Ctt	-7.55	0	0	benign	0.14	neutral	0.86	neutral	2.04	neutral	0.4	neutral	-0.12	low_impact	0.94	0.75	neutral	0.8	neutral	-0.93	0.02	neutral	0.34	0.5	0.11	neutral	0.25	neutral	0.31	neutral	0.41	neutral	2	0.06	neutral	0.86	deleterious	-6	neutral	0.17	neutral	-0.08	medium_impact	0.65	medium_impact	-0.35	medium_impact	0.68	0.85	31.63	19.86	0.31	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10642	10642	T	G	MI.16055	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	173	58	I	S	aTt/aGt	-0.63	0	0	possibly_damaging	0.56	neutral	0.49	neutral	1.93	neutral	-1.03	neutral	-1.66	neutral_impact	0.08	0.81	neutral	0.9	neutral	1.63	14.00	neutral	0.45	0.55	0.23	neutral	0.43	neutral	0.42	neutral	0.44	neutral	1	0.55	neutral	0.47	neutral	-3	neutral	0.61	deleterious	-0.9	medium_impact	0.2	medium_impact	-1.07	low_impact	0.64	0.8	31.63	19.86	0.31	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10642	10642	T	A	MI.16056	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	173	58	I	N	aTt/aAt	-0.63	0	0	possibly_damaging	0.83	neutral	0.3	neutral	1.88	neutral	-2.57	deleterious	-2.8	medium_impact	1.98	0.86	neutral	0.56	neutral	3.11	22.50	deleterious	0.44	0.55	0.37	neutral	0.61	disease	0.55	disease	0.72	disease	4	0.86	neutral	0.24	neutral	0	NA	0.68	deleterious	-1.43	low_impact	0.01	medium_impact	0.52	medium_impact	0.66	0.8	31.63	19.86	0.32	N	0.52	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10642	10642	T	C	MI.16057	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	173	58	I	T	aTt/aCt	-0.63	0	0	benign	0.06	neutral	0.37	neutral	1.95	neutral	-0.6	neutral	-0.97	neutral_impact	0.64	0.85	neutral	0.98	neutral	0.46	7.15	deleterious	0.53	0.6	0.14	neutral	0.24	neutral	0.43	neutral	0.41	neutral	2	0.59	neutral	0.66	deleterious	-6	neutral	0.52	deleterious	0.29	medium_impact	0.08	medium_impact	-0.6	medium_impact	0.63	0.8	31.63	19.86	0.41	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10643	10643	T	A	MI.16058	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	174	58	I	M	atT/atA	0.52	0	0	benign	0.11	neutral	0.38	neutral	1.95	neutral	-0.66	neutral	1.04	neutral_impact	-0.67	0.86	neutral	0.98	neutral	-0.79	0.04	neutral	0.65	0.7	0.11	neutral	0.12	neutral	0.35	neutral	0.33	neutral	3	0.56	neutral	0.64	deleterious	-6	neutral	0.15	neutral	0.03	medium_impact	0.09	medium_impact	-1.7	low_impact	0.79	0.85	31.63	19.86	0.39	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10643	10643	T	G	MI.16059	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	174	58	I	M	atT/atG	0.52	0	0	benign	0.11	neutral	0.38	neutral	1.95	neutral	-0.66	neutral	1.04	neutral_impact	-0.67	0.86	neutral	0.98	neutral	-1.14	0.01	neutral	0.65	0.7	0.11	neutral	0.12	neutral	0.35	neutral	0.33	neutral	3	0.56	neutral	0.64	deleterious	-6	neutral	0.15	neutral	0.03	medium_impact	0.09	medium_impact	-1.7	low_impact	0.79	0.85	31.63	19.86	0.39	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8442	8442	T	C	MI.1606	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	77	26	L	P	cTa/cCa	-1.03	0	0	probably_damaging	1	neutral	0.4	neutral	1.04	deleterious	-7.72	deleterious	-6.99	low_impact	1.54	0.97	neutral	0.08	damaging	3.85	23.40	deleterious	0.17170724	0.85	0.89	disease	0.7	disease	0.65	disease	0.74	disease	5	1	deleterious	0.2	neutral	-2	neutral	0.88	deleterious	-3.6	low_impact	0.19	medium_impact	0.22	medium_impact	0.57	0.85	1.47	7.57	0.36	N	0.97	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10644	10644	G	A	MI.16060	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	175	59	V	M	Gtg/Atg	-5.24	0	0	benign	0.03	neutral	0.52	neutral	1.95	neutral	-0.59	neutral	0.21	neutral_impact	-1.77	0.87	neutral	0.94	neutral	-0.14	1.47	neutral	0.58	0.65	0.13	neutral	0.16	neutral	0.23	neutral	0.26	neutral	5	0.45	neutral	0.75	deleterious	-6	neutral	0.08	neutral	0.58	medium_impact	0.23	medium_impact	-2.62	low_impact	0.92	0.95	28.57	15.27	0.3	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10644	10644	G	T	MI.16061	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	175	59	V	L	Gtg/Ttg	-5.24	0	0	benign	0.01	neutral	1	neutral	2.3	neutral	1.78	neutral	0.02	neutral_impact	-1.74	0.8	neutral	0.95	neutral	-0.76	0.05	neutral	0.49	0.55	0.17	neutral	0.27	neutral	0.22	neutral	0.42	neutral	2	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.03	medium_impact	1.88	high_impact	-2.6	low_impact	0.71	0.85	28.57	15.27	0.3	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10644	10644	G	C	MI.16062	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	175	59	V	L	Gtg/Ctg	-5.24	0	0	benign	0.01	neutral	1	neutral	2.3	neutral	1.78	neutral	0.02	neutral_impact	-1.74	0.8	neutral	0.95	neutral	-0.91	0.03	neutral	0.49	0.55	0.17	neutral	0.27	neutral	0.22	neutral	0.42	neutral	2	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.03	medium_impact	1.88	high_impact	-2.6	low_impact	0.71	0.85	28.57	15.27	0.3	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10645	10645	T	A	MI.16063	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	176	59	V	E	gTg/gAg	-0.63	0	0	possibly_damaging	0.45	neutral	0.3	neutral	1.87	deleterious	-3.17	deleterious	-3.97	low_impact	1.32	0.82	neutral	0.44	neutral	2.70	20.80	deleterious	0.25	0.45	0.49	neutral	0.74	disease	0.58	disease	0.75	disease	5	0.66	neutral	0.43	neutral	-3	neutral	0.50	deleterious	-0.72	medium_impact	0.01	medium_impact	-0.03	medium_impact	0.61	0.8	28.57	15.27	0.29	N	0.43	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10645	10645	T	G	MI.16064	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	176	59	V	G	gTg/gGg	-0.63	0	0	benign	0.36	neutral	0.48	neutral	1.89	neutral	-1.91	deleterious	-4.8	neutral_impact	0.77	0.81	neutral	0.72	neutral	0.49	7.37	deleterious	0.32	0.5	0.48	neutral	0.58	disease	0.46	neutral	0.51	disease	0	0.44	neutral	0.56	deleterious	-6	neutral	0.32	neutral	-0.57	medium_impact	0.19	medium_impact	-0.49	medium_impact	0.59	0.8	28.57	15.27	0.26	N	0.37	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10645	10645	T	C	MI.16065	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	176	59	V	A	gTg/gCg	-0.63	0	0	benign	0.02	neutral	0.63	neutral	1.95	neutral	-0.61	neutral	-2.25	neutral_impact	-1.25	0.77	neutral	1	neutral	-0.83	0.04	neutral	0.54	0.6	0.12	neutral	0.13	neutral	0.28	neutral	0.26	neutral	5	0.34	neutral	0.81	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.34	medium_impact	-2.19	low_impact	0.72	0.85	28.57	15.27	0.34	N	0.21	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10647	10647	C	T	MI.16066	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	178	60	P	S	Cct/Tct	-11.93	0	0	possibly_damaging	0.54	neutral	0.41	neutral	1.93	neutral	-0.79	deleterious	-7.8	low_impact	1.48	0.79	neutral	0.44	neutral	2.14	17.10	deleterious	0.3	0.45	0.16	neutral	0.95	disease	0.69	disease	0.8	disease	6	0.59	neutral	0.44	neutral	-3	neutral	0.37	neutral	-0.87	medium_impact	0.12	medium_impact	0.1	medium_impact	0.44	0.8	52.04	12.37	0.27	N	0.99	polymorphism	0.58	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10647	10647	C	G	MI.16067	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	178	60	P	A	Cct/Gct	-11.93	0	0	possibly_damaging	0.78	neutral	0.51	neutral	2.01	neutral	0.07	deleterious	-7.8	medium_impact	2.52	0.69	neutral	0.42	neutral	2.80	21.40	deleterious	0.46	0.55	0.33	neutral	0.88	disease	0.75	disease	0.78	disease	6	0.75	neutral	0.37	neutral	0	NA	0.63	deleterious	-1.31	low_impact	0.22	medium_impact	0.97	medium_impact	0.77	0.85	52.04	12.37	0.35	N	0.98	polymorphism	0.69	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10647	10647	C	A	MI.16068	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	178	60	P	T	Cct/Act	-11.93	0	0	benign	0.29	neutral	0.4	neutral	1.91	neutral	-1.34	deleterious	-7.8	medium_impact	2.77	0.71	neutral	0.33	neutral	1.88	15.49	deleterious	0.44	0.55	0.42	neutral	0.94	disease	0.75	disease	0.82	disease	6	0.52	neutral	0.56	deleterious	-3	neutral	0.35	neutral	-0.45	medium_impact	0.11	medium_impact	1.18	medium_impact	0.80	0.85	52.04	12.37	0.39	N	0.98	polymorphism	0.59	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10648	10648	C	T	MI.16069	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	179	60	P	L	cCt/cTt	4.44	0.99	0	probably_damaging	0.94	neutral	0.67	neutral	1.94	neutral	-0.65	deleterious	-9.74	medium_impact	2.09	0.65	neutral	0.35	neutral	4.28	24.00	deleterious	0.23	0.45	0.27	neutral	0.97	disease	0.7	disease	0.83	disease	7	0.93	neutral	0.37	neutral	1	deleterious	0.77	deleterious	-1.9	low_impact	0.38	medium_impact	0.61	medium_impact	0.73	0.85	52.04	12.37	0.42	N	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8442	8442	T	G	MI.1607	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	77	26	L	R	cTa/cGa	-1.03	0	0	probably_damaging	1	neutral	0.29	neutral	1.04	deleterious	-7	deleterious	-5.99	high_impact	3.68	0.97	neutral	0.05	damaging	4.07	23.70	deleterious	0.16813254	0.85	0.86	disease	0.74	disease	0.7	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.07	medium_impact	2.06	high_impact	0.42	0.85	1.47	7.57	0.42	N	0.96	polymorphism	0.93	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10648	10648	C	G	MI.16070	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	179	60	P	R	cCt/cGt	4.44	0.99	0	probably_damaging	0.97	neutral	0.35	neutral	1.86	neutral	-2.93	deleterious	-8.79	high_impact	4.16	0.62	neutral	0.27	damaging	3.55	23.10	deleterious	0.13	0.4	0.53	disease	0.97	disease	0.85	disease	0.92	disease	8	0.97	neutral	0.19	neutral	2	deleterious	0.86	deleterious	-2.19	low_impact	0.06	medium_impact	2.35	high_impact	0.72	0.85	52.04	12.37	0.67	P	0.98	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10648	10648	C	A	MI.16071	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	179	60	P	H	cCt/cAt	4.44	0.99	0	probably_damaging	0.99	neutral	0.54	neutral	1.85	deleterious	-3.53	deleterious	-8.8	high_impact	4.16	0.66	neutral	0.27	damaging	3.88	23.50	deleterious	0.16	0.45	0.68	disease	0.96	disease	0.84	disease	0.92	disease	8	0.99	deleterious	0.28	neutral	2	deleterious	0.86	deleterious	-2.63	low_impact	0.25	medium_impact	2.35	high_impact	0.75	0.85	52.04	12.37	0.62	P	0.91	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10650	10650	A	T	MI.16072	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	181	61	I	F	Att/Ttt	-20	0	0	possibly_damaging	0.68	neutral	0.8	neutral	1.79	neutral	-2.05	deleterious	-3.27	medium_impact	2.15	0.74	neutral	0.44	neutral	3.74	23.30	deleterious	0.25	0.45	0.43	neutral	0.83	disease	0.53	disease	0.76	disease	5	0.62	neutral	0.56	deleterious	0	NA	0.58	deleterious	-1.1	low_impact	0.54	medium_impact	0.66	medium_impact	0.71	0.85	29.59	10.13	0.26	N	0.88	disease_causing	0.5	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10650	10650	A	G	MI.16073	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	181	61	I	V	Att/Gtt	-20	0	0	benign	0.02	neutral	0.66	neutral	1.83	neutral	-1.43	neutral	-0.78	medium_impact	2.1	0.87	neutral	0.91	neutral	-0.15	1.38	neutral	0.35	0.5	0.27	neutral	0.4	neutral	0.35	neutral	0.45	neutral	1	0.3	neutral	0.82	deleterious	-3	neutral	0.11	neutral	0.75	medium_impact	0.37	medium_impact	0.62	medium_impact	0.52	0.8	29.59	10.13	0.37	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10650	10650	A	C	MI.16074	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	181	61	I	L	Att/Ctt	-20	0	0	benign	0.02	neutral	0.9	neutral	2.6	neutral	1.96	neutral	-0.93	neutral_impact	0.12	0.81	neutral	0.95	neutral	0.31	5.75	deleterious	0.27	0.45	0.13	neutral	0.47	neutral	0.24	neutral	0.45	neutral	1	0.05	neutral	0.94	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.74	medium_impact	-1.04	low_impact	0.55	0.8	29.59	10.13	0.35	N	0.45	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10651	10651	T	A	MI.16075	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	182	61	I	N	aTt/aAt	0.29	0.01	0	possibly_damaging	0.81	deleterious	0.04	neutral	1.73	deleterious	-4.39	deleterious	-6.03	high_impact	3.82	0.78	neutral	0.35	neutral	4.17	23.80	deleterious	0.28	0.45	0.71	disease	0.86	disease	0.54	disease	0.78	disease	6	0.97	neutral	0.12	neutral	5	deleterious	0.67	deleterious	-1.38	low_impact	-0.56	medium_impact	2.06	high_impact	0.56	0.8	29.59	10.13	0.39	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10651	10651	T	G	MI.16076	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	182	61	I	S	aTt/aGt	0.29	0.01	0	possibly_damaging	0.57	neutral	0.15	neutral	1.74	deleterious	-3.65	deleterious	-5.03	high_impact	3.82	0.71	neutral	0.31	neutral	3.85	23.40	deleterious	0.26	0.45	0.54	disease	0.86	disease	0.61	disease	0.78	disease	6	0.85	neutral	0.29	neutral	1	deleterious	0.44	deleterious	-0.92	medium_impact	-0.21	medium_impact	2.06	high_impact	0.50	0.8	29.59	10.13	0.43	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10651	10651	T	C	MI.16077	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	182	61	I	T	aTt/aCt	0.29	0.01	0	benign	0.09	neutral	0.47	neutral	1.76	deleterious	-3.09	deleterious	-4.04	medium_impact	3.02	0.92	neutral	0.72	neutral	1.41	12.85	neutral	0.38	0.5	0.47	neutral	0.72	disease	0.52	disease	0.61	disease	2	0.46	neutral	0.69	deleterious	-3	neutral	0.19	neutral	0.12	medium_impact	0.18	medium_impact	1.39	medium_impact	0.52	0.8	29.59	10.13	0.37	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10652	10652	T	G	MI.16078	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	183	61	I	M	atT/atG	4.67	0.7	0	benign	0.15	neutral	1	neutral	1.83	neutral	-1.41	neutral	-1.74	low_impact	1.5	0.81	neutral	0.83	neutral	-0.38	0.44	neutral	0.32	0.5	0.22	neutral	0.18	neutral	0.2	neutral	0.29	neutral	4	0.15	neutral	0.93	deleterious	-6	neutral	0.14	neutral	-0.11	medium_impact	1.88	high_impact	0.12	medium_impact	0.66	0.8	29.59	10.13	0.35	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10652	10652	T	A	MI.16079	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	183	61	I	M	atT/atA	4.67	0.7	0	benign	0.15	neutral	1	neutral	1.83	neutral	-1.41	neutral	-1.74	low_impact	1.5	0.81	neutral	0.83	neutral	-0.09	1.79	neutral	0.32	0.5	0.22	neutral	0.18	neutral	0.2	neutral	0.29	neutral	4	0.15	neutral	0.93	deleterious	-6	neutral	0.14	neutral	-0.11	medium_impact	1.88	high_impact	0.12	medium_impact	0.66	0.8	29.59	10.13	0.36	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8442	8442	T	A	MI.1608	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	77	26	L	Q	cTa/cAa	-1.03	0	0	probably_damaging	1	neutral	0.26	neutral	1.04	deleterious	-7.24	deleterious	-5.99	medium_impact	3.34	0.97	neutral	0.07	damaging	4.09	23.70	deleterious	0.21870687	0.85	0.87	disease	0.68	disease	0.65	disease	0.66	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.04	medium_impact	1.77	medium_impact	0.66	0.85	1.47	7.57	0.41	N	0.91	polymorphism	0.94	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10653	10653	G	A	MI.16080	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	184	62	A	T	Gcc/Acc	-6.16	0	0	benign	0	neutral	0.27	neutral	2.37	neutral	2.88	neutral	0.74	neutral_impact	-0.77	0.88	neutral	0.98	neutral	0.87	9.89	deleterious	0.24	0.45	0.11	neutral	0.31	neutral	0.24	neutral	0.44	neutral	1	0.73	neutral	0.64	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	-0.03	medium_impact	-1.78	low_impact	0.57	0.8	27.55	13.3	0.34	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10653	10653	G	C	MI.16081	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	184	62	A	P	Gcc/Ccc	-6.16	0	0	possibly_damaging	0.64	neutral	0.05	neutral	1.94	neutral	-2.37	neutral	-2.06	low_impact	0.9	0.67	neutral	0.52	neutral	3.45	23.00	deleterious	0.19	0.45	0.45	neutral	0.85	disease	0.62	disease	0.83	disease	7	0.95	neutral	0.21	neutral	-3	neutral	0.59	deleterious	-1.03	low_impact	-0.5	medium_impact	-0.38	medium_impact	0.77	0.85	27.55	13.3	0.33	N	0.27	polymorphism	1	0.03	rs386829108	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10653	10653	G	T	MI.16082	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	184	62	A	S	Gcc/Tcc	-6.16	0	0	benign	0.17	neutral	0.44	neutral	1.98	neutral	-0.52	neutral	-0.86	low_impact	0.9	0.78	neutral	0.72	neutral	1.88	15.49	deleterious	0.27	0.45	0.25	neutral	0.46	neutral	0.46	neutral	0.48	neutral	0	0.47	neutral	0.64	deleterious	-6	neutral	0.22	neutral	-0.17	medium_impact	0.15	medium_impact	-0.38	medium_impact	0.75	0.85	27.55	13.3	0.31	N	0.12	polymorphism	1	0.02	rs386829108	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10654	10654	C	G	MI.16083	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	185	62	A	G	gCc/gGc	-0.86	0	0.01	benign	0.25	neutral	0.2	neutral	1.97	neutral	-0.74	deleterious	-2.85	low_impact	1.24	0.76	neutral	0.61	neutral	2.22	17.65	deleterious	0.18	0.45	0.38	neutral	0.56	disease	0.48	neutral	0.54	disease	1	0.76	neutral	0.48	deleterious	-6	neutral	0.28	neutral	-0.37	medium_impact	-0.12	medium_impact	-0.1	medium_impact	0.72	0.85	27.55	13.3	0.37	N	0.33	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10654	10654	C	T	MI.16084	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	185	62	A	V	gCc/gTc	-0.86	0	0.01	benign	0.01	neutral	0.62	neutral	2.09	neutral	1.21	neutral	2.11	neutral_impact	-1.94	0.88	neutral	0.98	neutral	1.09	11.18	neutral	0.28	0.45	0.11	neutral	0.42	neutral	0.28	neutral	0.45	neutral	1	0.36	neutral	0.81	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.33	medium_impact	-2.76	low_impact	0.75	0.85	27.55	13.3	0.22	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10654	10654	C	A	MI.16085	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	185	62	A	D	gCc/gAc	-0.86	0	0.01	possibly_damaging	0.45	neutral	0.05	neutral	1.94	neutral	-2.98	neutral	-2.37	low_impact	1.24	0.72	neutral	0.43	neutral	4.08	23.70	deleterious	0.21	0.45	0.5	disease	0.8	disease	0.63	disease	0.79	disease	6	0.94	neutral	0.3	neutral	-3	neutral	0.52	deleterious	-0.72	medium_impact	-0.5	medium_impact	-0.1	medium_impact	0.71	0.85	27.55	13.3	0.32	N	0.30	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10656	10656	A	T	MI.16086	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	187	63	M	L	Ata/Tta	-8.7	0	0	benign	0	neutral	1	neutral	2.16	neutral	1.63	neutral	1.52	neutral_impact	-1.59	0.85	neutral	0.98	neutral	-1.11	0.01	neutral	0.38	0.5	0.14	neutral	0.41	neutral	0.39	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	1.88	high_impact	-2.47	low_impact	0.52	0.8	22.45	12.13	0.26	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10656	10656	A	C	MI.16087	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	187	63	M	L	Ata/Cta	-8.7	0	0	benign	0	neutral	1	neutral	2.16	neutral	1.63	neutral	1.52	neutral_impact	-1.59	0.85	neutral	0.98	neutral	-1.26	0.01	neutral	0.38	0.5	0.14	neutral	0.41	neutral	0.39	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	1.88	high_impact	-2.47	low_impact	0.52	0.8	22.45	12.13	0.26	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10656	10656	A	G	MI.16088	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	187	63	M	V	Ata/Gta	-8.7	0	0	benign	0.01	neutral	0.29	neutral	2.09	neutral	1.08	neutral	-0.65	low_impact	0.86	0.78	neutral	0.77	neutral	0.88	9.96	deleterious	0.37	0.5	0.2	neutral	0.78	disease	0.47	neutral	0.6	disease	2	0.71	neutral	0.64	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	-0.01	medium_impact	-0.42	medium_impact	0.56	0.8	22.45	12.13	0.31	N	0.16	polymorphism	1	0.02	rs28645634	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10657	10657	T	C	MI.16089	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	188	63	M	T	aTa/aCa	-1.55	0	0.01	benign	0.03	neutral	0.1	neutral	1.99	neutral	-0.22	deleterious	-2.86	medium_impact	2.52	0.82	neutral	0.73	neutral	1.07	11.04	neutral	0.34	0.5	0.33	neutral	0.79	disease	0.64	disease	0.73	disease	5	0.9	neutral	0.54	deleterious	-3	neutral	0.22	neutral	0.58	medium_impact	-0.32	medium_impact	0.97	medium_impact	0.37	0.8	22.45	12.13	0.37	N	0.47	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8444	8444	A	C	MI.1609	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	79	27	K	Q	Aaa/Caa	-2.88	0	0	probably_damaging	0.95	neutral	0.29	neutral	1.58	neutral	-0.21	deleterious	-3.98	medium_impact	3.23	0.97	neutral	0.13	damaging	3.33	22.90	deleterious	0.56366462	0.85	0.66	disease	0.6	disease	0.69	disease	0.66	disease	3	0.96	neutral	0.17	neutral	1	deleterious	0.80	deleterious	-1.97	low_impact	0.07	medium_impact	1.67	medium_impact	0.76	0.85	NA	NA	0.39	N	0.80	polymorphism	0.97	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10657	10657	T	A	MI.16090	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	188	63	M	K	aTa/aAa	-1.55	0	0.01	benign	0.04	deleterious	0.03	neutral	1.94	neutral	-2.03	deleterious	-3.98	medium_impact	2.52	0.75	neutral	0.41	neutral	2.10	16.83	deleterious	0.24	0.45	0.52	disease	0.94	disease	0.71	disease	0.87	disease	7	0.97	neutral	0.5	deleterious	1	deleterious	0.32	neutral	0.46	medium_impact	-0.63	medium_impact	0.97	medium_impact	0.54	0.8	22.45	12.13	0.32	N	0.67	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10658	10658	A	C	MI.16091	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	189	63	M	I	atA/atC	7.44	0.95	0.01	benign	0	neutral	0.27	neutral	2.11	neutral	1.31	neutral	0.27	neutral_impact	-0.24	0.77	neutral	0.99	neutral	0.31	5.80	deleterious	0.33	0.5	0.16	neutral	0.77	disease	0.44	neutral	0.6	disease	2	0.73	neutral	0.64	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	-0.03	medium_impact	-1.34	low_impact	0.59	0.8	22.45	12.13	0.45	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10658	10658	A	T	MI.16092	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	189	63	M	I	atA/atT	7.44	0.95	0.01	benign	0	neutral	0.27	neutral	2.11	neutral	1.31	neutral	0.27	neutral_impact	-0.24	0.77	neutral	0.99	neutral	0.37	6.38	deleterious	0.33	0.5	0.16	neutral	0.77	disease	0.44	neutral	0.6	disease	2	0.73	neutral	0.64	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	-0.03	medium_impact	-1.34	low_impact	0.59	0.8	22.45	12.13	0.45	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10659	10659	C	G	MI.16093	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	190	64	L	V	Cta/Gta	-5.24	0	0	possibly_damaging	0.9	neutral	0.38	neutral	1.39	neutral	-2.75	deleterious	-2.89	high_impact	4.01	0.63	neutral	0.08	damaging	3.38	23.00	deleterious	0.2	0.45	0.5	disease	0.82	disease	0.74	disease	0.76	disease	5	0.9	neutral	0.24	neutral	1	deleterious	0.76	deleterious	-1.68	low_impact	0.09	medium_impact	2.22	high_impact	0.72	0.85	53.06	11.99	0.35	N	0.75	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10659	10659	C	A	MI.16094	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	190	64	L	M	Cta/Ata	-5.24	0	0	possibly_damaging	0.76	neutral	0.13	neutral	1.32	deleterious	-3.88	neutral	-1.77	medium_impact	3.42	0.69	neutral	0.25	damaging	3.53	23.10	deleterious	0.2	0.45	0.62	disease	0.78	disease	0.56	disease	0.65	disease	3	0.91	neutral	0.19	neutral	0	NA	0.71	deleterious	-1.26	low_impact	-0.25	medium_impact	1.73	medium_impact	0.68	0.85	53.06	11.99	0.35	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10660	10660	T	A	MI.16095	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	191	64	L	Q	cTa/cAa	-0.63	0	0	probably_damaging	0.99	neutral	0.06	neutral	1.26	deleterious	-7.61	deleterious	-5.79	high_impact	4.7	0.57	damaging	0.07	damaging	4.36	24.10	deleterious	0.13	0.4	0.85	disease	0.93	disease	0.75	disease	0.86	disease	7	1	deleterious	0.04	neutral	2	deleterious	0.87	deleterious	-2.63	low_impact	-0.45	medium_impact	2.8	high_impact	0.61	0.8	53.06	11.99	0.51	P	0.99	disease_causing	0.99	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10660	10660	T	C	MI.16096	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	191	64	L	P	cTa/cCa	-0.63	0	0	probably_damaging	1	deleterious	0.03	neutral	1.26	deleterious	-7.93	deleterious	-6.82	high_impact	4.7	0.45	damaging	0.05	damaging	3.95	23.60	deleterious	0.12	0.4	0.88	disease	0.94	disease	0.82	disease	0.92	disease	8	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-3.55	low_impact	-0.63	medium_impact	2.8	high_impact	0.47	0.8	53.06	11.99	0.51	P	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10660	10660	T	G	MI.16097	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	191	64	L	R	cTa/cGa	-0.63	0	0	probably_damaging	0.99	deleterious	0.04	neutral	1.26	deleterious	-7.65	deleterious	-5.83	high_impact	4.7	0.53	damaging	0.05	damaging	4.20	23.90	deleterious	0.12	0.4	0.84	disease	0.96	disease	0.83	disease	0.92	disease	8	1	deleterious	0.03	neutral	6	deleterious	0.91	deleterious	-2.63	low_impact	-0.56	medium_impact	2.8	high_impact	0.43	0.8	53.06	11.99	0.51	P	0.99	disease_causing	0.99	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10662	10662	G	C	MI.16098	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	193	65	V	L	Gtc/Ctc	-0.4	0.17	0	benign	0.12	neutral	0.74	neutral	1.47	deleterious	-3.07	deleterious	-2.85	medium_impact	3.42	0.77	neutral	0.39	neutral	1.69	14.36	neutral	0.38	0.5	0.38	neutral	0.8	disease	0.54	disease	0.76	disease	5	0.15	neutral	0.81	deleterious	-3	neutral	0.26	neutral	-0.01	medium_impact	0.46	medium_impact	1.73	medium_impact	0.64	0.8	54.08	12.24	0.25	N	0.87	polymorphism	0.86	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10662	10662	G	T	MI.16099	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	193	65	V	F	Gtc/Ttc	-0.4	0.17	0	probably_damaging	0.92	neutral	0.77	neutral	1.41	deleterious	-4.43	deleterious	-4.84	medium_impact	3.27	0.66	neutral	0.41	neutral	3.79	23.40	deleterious	0.25	0.45	0.59	disease	0.94	disease	0.6	disease	0.82	disease	6	0.9	neutral	0.43	neutral	1	deleterious	0.80	deleterious	-1.78	low_impact	0.5	medium_impact	1.6	medium_impact	0.49	0.8	54.08	12.24	0.3	N	0.96	disease_causing	0.64	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8602	8602	T	C	MI.161	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	76	26	F	L	Ttt/Ctt	-2.65	0	0.01	benign	0	neutral	1	neutral	4.49	neutral	0.67	neutral	-1.96	neutral_impact	-0.38	0.96	neutral	0.92	neutral	-0.82	0.04	neutral	0.42	0.65	0.29	neutral	0.15	neutral	0.27	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.98	high_impact	-1.42	low_impact	0.39	0.9	15.49	8.03	0.32	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8444	8444	A	G	MI.1610	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	79	27	K	E	Aaa/Gaa	-2.88	0	0	possibly_damaging	0.87	neutral	0.27	neutral	1.58	neutral	-0.34	deleterious	-3.98	high_impact	3.92	0.83	neutral	0.13	damaging	3.88	23.50	deleterious	0.28300158	0.85	0.66	disease	0.62	disease	0.75	disease	0.68	disease	4	0.9	neutral	0.2	neutral	1	deleterious	0.81	deleterious	-1.54	low_impact	0.05	medium_impact	2.26	high_impact	0.66	0.85	NA	NA	0.4	N	0.86	polymorphism	0.96	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10662	10662	G	A	MI.16100	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	193	65	V	I	Gtc/Atc	-0.4	0.17	0	benign	0.2	neutral	0.42	neutral	1.47	deleterious	-3.04	neutral	-0.86	medium_impact	2.62	0.76	neutral	0.54	neutral	0.71	8.87	deleterious	0.38	0.5	0.38	neutral	0.7	disease	0.48	neutral	0.53	disease	1	0.49	neutral	0.61	deleterious	-3	neutral	0.29	neutral	-0.25	medium_impact	0.13	medium_impact	1.06	medium_impact	0.79	0.85	54.08	12.24	0.33	N	0.80	polymorphism	0.95	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10663	10663	T	C	MI.16101	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	194	65	V	A	gTc/gCc	0.98	0.75	0	possibly_damaging	0.8	neutral	0.62	neutral	1.53	neutral	-2.23	deleterious	-3.98	medium_impact	2.15	0.28	damaging	0.25	damaging	1.28	12.18	neutral	0.43	0.55	0.19	neutral	0.28	neutral	0.36	neutral	0.43	neutral	1	0.77	neutral	0.41	neutral	0	NA	0.58	deleterious	-1.35	low_impact	0.33	medium_impact	0.66	medium_impact	0.33	0.8	54.08	12.24	0.9	P	0.89	disease_causing_automatic	0.12	0.10	rs193302933	Pathogenic	Leber's_optic_atrophy	24746	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	T10663C	LHON	+	-	Cfrm	9	P	P	P	neutral
chrM	10663	10663	T	A	MI.16102	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	194	65	V	D	gTc/gAc	0.98	0.75	0	probably_damaging	0.98	neutral	0.2	neutral	1.39	deleterious	-6.18	deleterious	-6.89	high_impact	3.97	0.7	neutral	0.37	neutral	4.68	24.60	deleterious	0.11	0.4	0.65	disease	0.94	disease	0.7	disease	0.86	disease	7	0.99	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	-0.12	medium_impact	2.19	high_impact	0.53	0.8	54.08	12.24	0.42	N	0.98	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10663	10663	T	G	MI.16103	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	194	65	V	G	gTc/gGc	0.98	0.75	0	probably_damaging	0.97	neutral	0.36	neutral	1.4	deleterious	-4.9	deleterious	-6.96	medium_impact	2.82	0.74	neutral	0.45	neutral	3.80	23.40	deleterious	0.27	0.45	0.52	disease	0.91	disease	0.57	disease	0.79	disease	6	0.97	neutral	0.2	neutral	1	deleterious	0.79	deleterious	-2.19	low_impact	0.07	medium_impact	1.23	medium_impact	0.50	0.8	54.08	12.24	0.35	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10665	10665	T	G	MI.16104	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	196	66	F	V	Ttt/Gtt	-2.71	0	0	benign	0.36	neutral	0.45	neutral	1.99	neutral	0.59	deleterious	-6.8	medium_impact	2.68	0.74	neutral	0.45	neutral	2.33	18.35	deleterious	0.21	0.45	0.52	disease	0.95	disease	0.67	disease	0.82	disease	6	0.47	neutral	0.55	deleterious	-3	neutral	0.41	neutral	-0.57	medium_impact	0.16	medium_impact	1.11	medium_impact	0.43	0.8	55.1	11.43	0.28	N	0.90	disease_causing	0.81	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10665	10665	T	A	MI.16105	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	196	66	F	I	Ttt/Att	-2.71	0	0	benign	0.11	neutral	0.38	neutral	2.25	neutral	-0.7	deleterious	-5.81	medium_impact	2.94	0.77	neutral	0.65	neutral	2.46	19.19	deleterious	0.34	0.5	0.55	disease	0.93	disease	0.53	disease	0.6	disease	2	0.56	neutral	0.64	deleterious	-3	neutral	0.31	neutral	0.03	medium_impact	0.09	medium_impact	1.33	medium_impact	0.49	0.8	55.1	11.43	0.31	N	0.66	disease_causing	0.66	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10665	10665	T	C	MI.16106	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	196	66	F	L	Ttt/Ctt	-2.71	0	0	benign	0.08	neutral	0.75	neutral	1.97	neutral	-0.18	deleterious	-5.77	low_impact	1.84	0.81	neutral	0.71	neutral	2.05	16.50	deleterious	0.53	0.6	0.45	neutral	0.81	disease	0.47	neutral	0.57	disease	1	0.15	neutral	0.84	deleterious	-6	neutral	0.25	neutral	0.17	medium_impact	0.48	medium_impact	0.4	medium_impact	0.47	0.8	55.1	11.43	0.21	N	0.89	disease_causing	0.69	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10666	10666	T	A	MI.16107	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	197	66	F	Y	tTt/tAt	5.6	1	0	possibly_damaging	0.89	neutral	0.71	neutral	1.79	deleterious	-3.61	deleterious	-2.94	high_impact	4.11	0.75	neutral	0.43	neutral	4.17	23.80	deleterious	0.25	0.45	0.54	disease	0.93	disease	0.65	disease	0.76	disease	5	0.87	neutral	0.41	neutral	1	deleterious	0.74	deleterious	-1.64	low_impact	0.43	medium_impact	2.31	high_impact	0.51	0.8	55.1	11.43	0.63	P	0.85	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10666	10666	T	G	MI.16108	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	197	66	F	C	tTt/tGt	5.6	1	0	probably_damaging	0.98	neutral	0.17	neutral	1.78	deleterious	-4.48	deleterious	-7.82	high_impact	4.46	0.68	neutral	0.41	neutral	4.09	23.70	deleterious	0.2	0.45	0.83	disease	0.95	disease	0.71	disease	0.85	disease	7	0.99	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	-0.17	medium_impact	2.6	high_impact	0.31	0.8	55.1	11.43	0.7	P	0.96	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10666	10666	T	C	MI.16109	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	197	66	F	S	tTt/tCt	5.6	1	0	probably_damaging	0.93	neutral	0.46	neutral	1.81	deleterious	-3.48	deleterious	-7.83	high_impact	4.11	0.75	neutral	0.46	neutral	4.17	23.80	deleterious	0.18	0.45	0.6	disease	0.96	disease	0.66	disease	0.82	disease	6	0.92	neutral	0.27	neutral	2	deleterious	0.80	deleterious	-1.83	low_impact	0.17	medium_impact	2.31	high_impact	0.37	0.8	55.1	11.43	0.66	P	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8445	8445	A	C	MI.1611	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	80	27	K	T	aAa/aCa	8.46	1	0	probably_damaging	0.92	neutral	0.4	neutral	1.59	neutral	1.25	deleterious	-5.98	high_impact	3.58	0.95	neutral	0.13	damaging	3.30	22.90	deleterious	0.18580261	0.85	0.75	disease	0.51	disease	0.73	disease	0.65	disease	3	0.92	neutral	0.24	neutral	2	deleterious	0.81	deleterious	-1.76	low_impact	0.19	medium_impact	1.97	medium_impact	0.63	0.85	NA	NA	0.64	P	0.81	disease_causing	0.96	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10667	10667	T	A	MI.16110	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	198	66	F	L	ttT/ttA	7.44	1	0	benign	0.08	neutral	0.75	neutral	1.97	neutral	-0.18	deleterious	-5.77	low_impact	1.84	0.81	neutral	0.71	neutral	2.52	19.56	deleterious	0.53	0.6	0.45	neutral	0.81	disease	0.47	neutral	0.57	disease	1	0.15	neutral	0.84	deleterious	-6	neutral	0.25	neutral	0.17	medium_impact	0.48	medium_impact	0.4	medium_impact	0.47	0.8	55.1	11.43	0.52	N	0.89	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10667	10667	T	G	MI.16111	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	198	66	F	L	ttT/ttG	7.44	1	0	benign	0.08	neutral	0.75	neutral	1.97	neutral	-0.18	deleterious	-5.77	low_impact	1.84	0.81	neutral	0.71	neutral	2.38	18.72	deleterious	0.53	0.6	0.45	neutral	0.81	disease	0.47	neutral	0.57	disease	1	0.15	neutral	0.84	deleterious	-6	neutral	0.25	neutral	0.17	medium_impact	0.48	medium_impact	0.4	medium_impact	0.47	0.8	55.1	11.43	0.52	N	0.89	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10668	10668	G	A	MI.16112	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	199	67	A	T	Gcc/Acc	-4.32	0	0	benign	0.28	neutral	0.48	neutral	1.74	neutral	-2.84	deleterious	-3.48	medium_impact	2.98	0.81	neutral	0.64	neutral	4.16	23.80	deleterious	0.49	0.55	0.47	neutral	0.82	disease	0.59	disease	0.75	disease	5	0.42	neutral	0.6	deleterious	-3	neutral	0.78	deleterious	-0.43	medium_impact	0.19	medium_impact	1.36	medium_impact	0.75	0.85	53.06	9.88	0.29	N	0.70	polymorphism	0.75	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10668	10668	G	T	MI.16113	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	199	67	A	S	Gcc/Tcc	-4.32	0	0	possibly_damaging	0.64	neutral	0.68	neutral	1.88	neutral	-1.4	neutral	-2.38	neutral_impact	0.46	0.75	neutral	0.87	neutral	0.75	9.15	deleterious	0.49	0.55	0.12	neutral	0.22	neutral	0.33	neutral	0.38	neutral	2	0.57	neutral	0.52	deleterious	-3	neutral	0.52	deleterious	-1.03	low_impact	0.39	medium_impact	-0.75	medium_impact	0.65	0.8	53.06	9.88	0.32	N	0.45	polymorphism	0.87	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10668	10668	G	C	MI.16114	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	199	67	A	P	Gcc/Ccc	-4.32	0	0	benign	0.17	neutral	0.21	neutral	1.68	deleterious	-4.86	deleterious	-4.26	high_impact	4.08	0.57	damaging	0.36	neutral	1.89	15.55	deleterious	0.17	0.45	0.68	disease	0.97	disease	0.7	disease	0.88	disease	8	0.75	neutral	0.52	deleterious	-2	neutral	0.39	neutral	-0.17	medium_impact	-0.11	medium_impact	2.28	high_impact	0.61	0.8	53.06	9.88	0.37	N	0.88	disease_causing	0.54	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10669	10669	C	A	MI.16115	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	200	67	A	D	gCc/gAc	3.52	1	0	probably_damaging	0.93	neutral	0.21	neutral	1.71	deleterious	-5.06	deleterious	-5.31	high_impact	4.08	0.64	neutral	0.29	neutral	4.45	24.20	deleterious	0.21	0.45	0.71	disease	0.96	disease	0.68	disease	0.85	disease	7	0.95	neutral	0.14	neutral	2	deleterious	0.85	deleterious	-1.83	low_impact	-0.11	medium_impact	2.28	high_impact	0.52	0.8	53.06	9.88	0.58	P	0.98	disease_causing	0.99	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10669	10669	C	T	MI.16116	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	200	67	A	V	gCc/gTc	3.52	1	0	possibly_damaging	0.75	neutral	0.68	neutral	1.71	deleterious	-3.38	deleterious	-3.77	medium_impact	2.66	0.72	neutral	0.55	neutral	4.45	24.20	deleterious	0.59	0.65	0.6	disease	0.9	disease	0.59	disease	0.78	disease	6	0.7	neutral	0.47	neutral	0	NA	0.80	deleterious	-1.24	low_impact	0.39	medium_impact	1.09	medium_impact	0.73	0.85	53.06	9.88	0.52	N	0.89	disease_causing	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10669	10669	C	G	MI.16117	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	200	67	A	G	gCc/gGc	3.52	1	0	benign	0.08	neutral	0.41	neutral	1.95	deleterious	-3.78	deleterious	-3.52	medium_impact	2.12	0.83	neutral	0.68	neutral	2.04	16.44	deleterious	0.36	0.5	0.51	disease	0.89	disease	0.43	neutral	0.61	disease	2	0.54	neutral	0.67	deleterious	-3	neutral	0.30	neutral	0.17	medium_impact	0.12	medium_impact	0.64	medium_impact	0.72	0.85	53.06	9.88	0.52	N	0.62	disease_causing	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10671	10671	G	T	MI.16118	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	202	68	A	S	Gcc/Tcc	-11.01	0	0	probably_damaging	0.92	neutral	0.22	neutral	1.55	deleterious	-3.49	deleterious	-2.79	high_impact	4.57	0.63	neutral	0.39	neutral	3.64	23.20	deleterious	0.4	0.5	0.49	neutral	0.94	disease	0.65	disease	0.81	disease	6	0.95	neutral	0.15	neutral	2	deleterious	0.83	deleterious	-1.78	low_impact	-0.1	medium_impact	2.69	high_impact	0.65	0.8	53.06	12.04	0.54	N	0.82	polymorphism	0.83	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10671	10671	G	A	MI.16119	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	202	68	A	T	Gcc/Acc	-11.01	0	0	probably_damaging	0.97	neutral	0.18	neutral	1.56	deleterious	-3.87	deleterious	-3.78	high_impact	4.22	0.65	neutral	0.31	neutral	4.23	23.90	deleterious	0.42	0.5	0.52	disease	0.93	disease	0.66	disease	0.77	disease	5	0.98	neutral	0.11	neutral	2	deleterious	0.84	deleterious	-2.19	low_impact	-0.16	medium_impact	2.4	high_impact	0.65	0.8	53.06	12.04	0.46	N	0.94	polymorphism	0.69	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8445	8445	A	T	MI.1612	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	80	27	K	M	aAa/aTa	8.46	1	0	probably_damaging	0.98	neutral	0.26	neutral	1.79	neutral	5.13	deleterious	-5.98	high_impact	3.92	0.95	neutral	0.12	damaging	3.62	23.20	deleterious	0.17628270	0.85	0.89	disease	0.52	disease	0.74	disease	0.66	disease	3	0.99	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-2.36	low_impact	0.04	medium_impact	2.26	high_impact	0.67	0.85	NA	NA	0.62	P	0.69	disease_causing	0.98	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10671	10671	G	C	MI.16120	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	202	68	A	P	Gcc/Ccc	-11.01	0	0	possibly_damaging	0.5	neutral	0.05	neutral	1.52	deleterious	-5.42	deleterious	-4.44	high_impact	4.22	0.59	damaging	0.36	neutral	2.12	17.00	deleterious	0.21	0.45	0.75	disease	0.96	disease	0.73	disease	0.86	disease	7	0.95	neutral	0.28	neutral	1	deleterious	0.54	deleterious	-0.8	medium_impact	-0.5	medium_impact	2.4	high_impact	0.65	0.8	53.06	12.04	0.4	N	0.88	disease_causing	0.62	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10672	10672	C	A	MI.16121	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	203	68	A	D	gCc/gAc	7.44	1	0	probably_damaging	0.98	neutral	0.07	neutral	1.52	deleterious	-5.48	deleterious	-5.61	high_impact	4.57	0.62	neutral	0.33	neutral	4.56	24.40	deleterious	0.16	0.45	0.79	disease	0.97	disease	0.74	disease	0.88	disease	8	1	deleterious	0.05	neutral	2	deleterious	0.89	deleterious	-2.35	low_impact	-0.41	medium_impact	2.69	high_impact	0.59	0.8	53.06	12.04	0.66	P	0.96	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10672	10672	C	T	MI.16122	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	203	68	A	V	gCc/gTc	7.44	1	0	probably_damaging	0.98	neutral	0.38	neutral	1.75	neutral	-2.6	deleterious	-3.85	medium_impact	2.12	0.67	neutral	0.64	neutral	4.52	24.30	deleterious	0.5	0.6	0.19	neutral	0.92	disease	0.49	neutral	0.56	disease	1	0.98	neutral	0.2	neutral	1	deleterious	0.76	deleterious	-2.35	low_impact	0.09	medium_impact	0.64	medium_impact	0.61	0.8	53.06	12.04	0.56	P	0.88	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10672	10672	C	G	MI.16123	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	203	68	A	G	gCc/gGc	7.44	1	0	benign	0.3	neutral	0.14	neutral	1.55	deleterious	-3.69	deleterious	-3.54	high_impact	4.57	0.72	neutral	0.56	neutral	2.24	17.75	deleterious	0.32	0.5	0.61	disease	0.93	disease	0.65	disease	0.76	disease	5	0.83	neutral	0.42	neutral	-2	neutral	0.83	deleterious	-0.47	medium_impact	-0.23	medium_impact	2.69	high_impact	0.78	0.85	53.06	12.04	0.69	P	0.81	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10674	10674	T	G	MI.16124	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	205	69	C	G	Tgc/Ggc	-10.08	0	0	probably_damaging	0.94	neutral	0.32	neutral	1.75	deleterious	-3.37	deleterious	-11.42	high_impact	4.12	0.64	neutral	0.4	neutral	3.28	22.80	deleterious	0.31	0.45	0.68	disease	0.97	disease	0.7	disease	0.85	disease	7	0.95	neutral	0.19	neutral	2	deleterious	0.79	deleterious	-1.9	low_impact	0.03	medium_impact	2.32	high_impact	0.35	0.8	54.08	12.17	0.46	N	0.90	disease_causing	0.98	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10674	10674	T	A	MI.16125	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	205	69	C	S	Tgc/Agc	-10.08	0	0	probably_damaging	0.96	neutral	0.35	neutral	1.82	neutral	-2.58	deleterious	-9.54	medium_impact	3.15	0.66	neutral	0.37	neutral	3.66	23.20	deleterious	0.38	0.5	0.6	disease	0.97	disease	0.69	disease	0.81	disease	6	0.96	neutral	0.2	neutral	1	deleterious	0.83	deleterious	-2.07	low_impact	0.06	medium_impact	1.5	medium_impact	0.41	0.8	54.08	12.17	0.37	N	0.78	disease_causing	0.97	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10674	10674	T	C	MI.16126	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	205	69	C	R	Tgc/Cgc	-10.08	0	0	probably_damaging	0.98	neutral	0.08	neutral	1.71	deleterious	-4.81	deleterious	-11.45	high_impact	4.32	0.56	damaging	0.24	damaging	3.51	23.10	deleterious	0.3	0.45	0.84	disease	0.98	disease	0.78	disease	0.86	disease	7	0.99	deleterious	0.05	neutral	2	deleterious	0.90	deleterious	-2.35	low_impact	-0.38	medium_impact	2.48	high_impact	0.26	0.8	54.08	12.17	0.51	N	0.92	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10675	10675	G	C	MI.16127	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	206	69	C	S	tGc/tCc	7.44	1	0	probably_damaging	0.96	neutral	0.35	neutral	1.82	neutral	-2.58	deleterious	-9.54	medium_impact	3.15	0.66	neutral	0.37	neutral	3.20	22.70	deleterious	0.38	0.5	0.6	disease	0.97	disease	0.69	disease	0.81	disease	6	0.96	neutral	0.2	neutral	1	deleterious	0.83	deleterious	-2.07	low_impact	0.06	medium_impact	1.5	medium_impact	0.41	0.8	54.08	12.17	0.57	P	0.78	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10675	10675	G	A	MI.16128	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	206	69	C	Y	tGc/tAc	7.44	1	0	probably_damaging	0.92	neutral	0.29	neutral	1.7	deleterious	-5.55	deleterious	-10.29	high_impact	4.67	0.64	neutral	0.25	damaging	3.50	23.10	deleterious	0.31	0.45	0.9	disease	0.98	disease	0.73	disease	0.85	disease	7	0.93	neutral	0.19	neutral	2	deleterious	0.83	deleterious	-1.78	low_impact	-0.01	medium_impact	2.78	high_impact	0.36	0.8	54.08	12.17	0.64	P	0.89	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10675	10675	G	T	MI.16129	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	206	69	C	F	tGc/tTc	7.44	1	0	probably_damaging	0.92	neutral	0.33	neutral	1.72	deleterious	-5.07	deleterious	-10.34	high_impact	4.67	0.64	neutral	0.26	damaging	3.81	23.40	deleterious	0.27	0.45	0.87	disease	0.98	disease	0.73	disease	0.85	disease	7	0.93	neutral	0.21	neutral	2	deleterious	0.83	deleterious	-1.78	low_impact	0.04	medium_impact	2.78	high_impact	0.36	0.8	54.08	12.17	0.64	P	0.93	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8446	8446	A	C	MI.1613	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	81	27	K	N	aaA/aaC	4.29	1	0	probably_damaging	0.95	neutral	0.36	neutral	1.58	neutral	-0.54	deleterious	-4.98	medium_impact	2.82	0.98	neutral	0.39	neutral	3.66	23.20	deleterious	0.56663707	0.85	0.73	disease	0.54	disease	0.62	disease	0.61	disease	2	0.95	neutral	0.21	neutral	1	deleterious	0.82	deleterious	-1.97	low_impact	0.15	medium_impact	1.32	medium_impact	0.60	0.85	NA	NA	0.62	P	0.71	disease_causing	0.9	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10676	10676	C	A	MI.16130	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	207	69	C	W	tgC/tgA	7.44	1	0.01	benign	0.12	neutral	0.06	neutral	1.68	deleterious	-7.2	deleterious	-10.01	high_impact	3.77	0.62	neutral	0.32	neutral	2.63	20.40	deleterious	0.22	0.45	0.96	disease	0.98	disease	0.76	disease	0.83	disease	7	0.93	neutral	0.47	deleterious	-2	neutral	0.39	neutral	-0.01	medium_impact	-0.45	medium_impact	2.02	high_impact	0.20	0.8	54.08	12.17	0.5	P	0.91	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10676	10676	C	G	MI.16131	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	207	69	C	W	tgC/tgG	7.44	1	0.01	benign	0.12	neutral	0.06	neutral	1.68	deleterious	-7.2	deleterious	-10.01	high_impact	3.77	0.62	neutral	0.32	neutral	2.36	18.55	deleterious	0.22	0.45	0.96	disease	0.98	disease	0.76	disease	0.83	disease	7	0.93	neutral	0.47	deleterious	-2	neutral	0.39	neutral	-0.01	medium_impact	-0.45	medium_impact	2.02	high_impact	0.20	0.8	54.08	12.17	0.49	N	0.91	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10677	10677	G	C	MI.16132	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	208	70	E	Q	Gaa/Caa	-5.47	0	0	probably_damaging	0.91	neutral	0.3	neutral	1.54	deleterious	-6.32	deleterious	-2.96	high_impact	4.73	0.54	damaging	0.48	neutral	3.38	23.00	deleterious	0.42	0.55	0.79	disease	0.94	disease	0.71	disease	0.85	disease	7	0.92	neutral	0.2	neutral	2	deleterious	0.84	deleterious	-1.72	low_impact	0.01	medium_impact	2.83	high_impact	0.65	0.8	52.04	12.46	0.67	P	0.84	disease_causing	0.94	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10677	10677	G	A	MI.16133	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	208	70	E	K	Gaa/Aaa	-5.47	0	0	benign	0.29	neutral	0.29	neutral	1.56	deleterious	-5.94	deleterious	-3.94	high_impact	4.73	0.48	damaging	0.3	neutral	2.78	21.30	deleterious	0.35	0.5	0.75	disease	0.98	disease	0.75	disease	0.86	disease	7	0.65	neutral	0.5	deleterious	-2	neutral	0.46	deleterious	-0.45	medium_impact	-0.01	medium_impact	2.83	high_impact	0.71	0.85	52.04	12.46	0.64	P	1.00	disease_causing	0.99	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10678	10678	A	G	MI.16134	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	209	70	E	G	gAa/gGa	4.44	1	0	probably_damaging	0.96	neutral	0.35	neutral	1.52	deleterious	-6.43	deleterious	-6.9	medium_impact	3.19	0.57	damaging	0.66	neutral	4.27	23.90	deleterious	0.32	0.5	0.78	disease	0.94	disease	0.61	disease	0.61	disease	2	0.96	neutral	0.2	neutral	1	deleterious	0.87	deleterious	-2.07	low_impact	0.06	medium_impact	1.54	medium_impact	0.28	0.8	52.04	12.46	0.53	P	0.73	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10678	10678	A	C	MI.16135	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	209	70	E	A	gAa/gCa	4.44	1	0	probably_damaging	0.91	neutral	0.53	neutral	1.58	deleterious	-6.2	deleterious	-5.9	high_impact	4.73	0.61	neutral	0.49	neutral	3.72	23.30	deleterious	0.23	0.45	0.78	disease	0.93	disease	0.67	disease	0.76	disease	5	0.9	neutral	0.31	neutral	2	deleterious	0.83	deleterious	-1.72	low_impact	0.24	medium_impact	2.83	high_impact	0.46	0.8	52.04	12.46	0.67	P	0.84	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10678	10678	A	T	MI.16136	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	209	70	E	V	gAa/gTa	4.44	1	0	probably_damaging	0.98	neutral	0.52	neutral	1.62	deleterious	-7.36	deleterious	-6.87	high_impact	4.73	0.61	neutral	0.44	neutral	4.28	24.00	deleterious	0.22	0.45	0.88	disease	0.97	disease	0.71	disease	0.85	disease	7	0.98	neutral	0.27	neutral	2	deleterious	0.90	deleterious	-2.35	low_impact	0.23	medium_impact	2.83	high_impact	0.42	0.8	52.04	12.46	0.67	P	0.89	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10679	10679	A	T	MI.16137	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	210	70	E	D	gaA/gaT	8.59	1	0	possibly_damaging	0.89	neutral	0.21	neutral	1.53	deleterious	-5.15	deleterious	-2.96	high_impact	4.04	0.63	neutral	0.47	neutral	3.85	23.40	deleterious	0.53	0.6	0.63	disease	0.94	disease	0.61	disease	0.73	disease	5	0.93	neutral	0.16	neutral	1	deleterious	0.83	deleterious	-1.64	low_impact	-0.11	medium_impact	2.25	high_impact	0.66	0.8	52.04	12.46	0.68	P	0.83	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10679	10679	A	C	MI.16138	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	210	70	E	D	gaA/gaC	8.59	1	0	possibly_damaging	0.89	neutral	0.21	neutral	1.53	deleterious	-5.15	deleterious	-2.96	high_impact	4.04	0.63	neutral	0.47	neutral	3.73	23.30	deleterious	0.53	0.6	0.63	disease	0.94	disease	0.61	disease	0.73	disease	5	0.93	neutral	0.16	neutral	1	deleterious	0.83	deleterious	-1.64	low_impact	-0.11	medium_impact	2.25	high_impact	0.66	0.8	52.04	12.46	0.68	P	0.83	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10680	10680	G	A	MI.16139	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	211	71	A	T	Gca/Aca	0.06	0.94	0.01	benign	0.05	neutral	0.09	neutral	1.94	neutral	-2.9	deleterious	-2.98	high_impact	3.99	0.72	neutral	0.6	neutral	2.35	18.51	deleterious	0.38	0.5	0.5	disease	0.89	disease	0.59	disease	0.57	disease	1	0.9	neutral	0.52	deleterious	-2	neutral	0.31	neutral	0.37	medium_impact	-0.35	medium_impact	2.21	high_impact	0.70	0.85	51.02	11.05	0.42	N	0.02	disease_causing	0.97	0.18	.	.	.	.	.	.	.	.	.	G10680A	LHON / synergistic combo 10680A + 12033G + 14258A	+	-	Reported / possibly synergistic	3	.	N	N	damaging
chrM	8446	8446	A	T	MI.1614	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	81	27	K	N	aaA/aaT	4.29	1	0	probably_damaging	0.95	neutral	0.36	neutral	1.58	neutral	-0.54	deleterious	-4.98	medium_impact	2.82	0.98	neutral	0.39	neutral	3.71	23.30	deleterious	0.56663707	0.85	0.73	disease	0.54	disease	0.62	disease	0.61	disease	2	0.95	neutral	0.21	neutral	1	deleterious	0.82	deleterious	-1.97	low_impact	0.15	medium_impact	1.32	medium_impact	0.60	0.85	NA	NA	0.63	P	0.71	disease_causing	0.9	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10680	10680	G	T	MI.16140	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	211	71	A	S	Gca/Tca	0.06	0.94	0.01	possibly_damaging	0.64	neutral	0.25	neutral	1.76	neutral	-2.15	neutral	-2.47	medium_impact	2.92	0.65	neutral	0.39	neutral	2.17	17.33	deleterious	0.48	0.55	0.43	neutral	0.94	disease	0.58	disease	0.77	disease	5	0.77	neutral	0.31	neutral	0	NA	0.68	deleterious	-1.03	low_impact	-0.06	medium_impact	1.31	medium_impact	0.64	0.8	51.02	11.05	0.42	N	0.63	disease_causing	0.94	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10680	10680	G	C	MI.16141	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	211	71	A	P	Gca/Cca	0.06	0.94	0.01	probably_damaging	0.95	neutral	0.07	neutral	1.67	deleterious	-4.58	deleterious	-4.46	high_impact	4.54	0.56	damaging	0.29	neutral	3.83	23.40	deleterious	0.23	0.45	0.71	disease	0.96	disease	0.75	disease	0.89	disease	8	0.99	deleterious	0.06	neutral	2	deleterious	0.86	deleterious	-1.97	low_impact	-0.41	medium_impact	2.67	high_impact	0.58	0.8	51.02	11.05	0.56	P	0.86	disease_causing	0.99	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10681	10681	C	T	MI.16142	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	212	71	A	V	gCa/gTa	5.13	1	0	possibly_damaging	0.75	neutral	0.27	neutral	1.77	neutral	-1.64	deleterious	-3.53	high_impact	4.2	0.65	neutral	0.29	neutral	4.12	23.80	deleterious	0.44	0.55	0.61	disease	0.92	disease	0.63	disease	0.75	disease	5	0.82	neutral	0.26	neutral	1	deleterious	0.70	deleterious	-1.24	low_impact	-0.03	medium_impact	2.38	high_impact	0.69	0.85	51.02	11.05	0.69	P	0.58	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10681	10681	C	G	MI.16143	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	212	71	A	G	gCa/gGa	5.13	1	0	benign	0.08	neutral	0.51	neutral	1.72	neutral	-2.09	deleterious	-3.44	low_impact	1.84	0.67	neutral	0.46	neutral	2.04	16.46	deleterious	0.4	0.5	0.21	neutral	0.92	disease	0.44	neutral	0.73	disease	5	0.42	neutral	0.72	deleterious	-6	neutral	0.23	neutral	0.17	medium_impact	0.22	medium_impact	0.4	medium_impact	0.73	0.85	51.02	11.05	0.55	P	0.63	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10681	10681	C	A	MI.16144	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	212	71	A	E	gCa/gAa	5.13	1	0	possibly_damaging	0.87	neutral	0.26	neutral	1.7	deleterious	-3.8	deleterious	-4.46	high_impact	4.54	0.61	neutral	0.36	neutral	4.40	24.10	deleterious	0.17	0.45	0.6	disease	0.95	disease	0.71	disease	0.86	disease	7	0.9	neutral	0.2	neutral	1	deleterious	0.82	deleterious	-1.56	low_impact	-0.04	medium_impact	2.67	high_impact	0.51	0.8	51.02	11.05	0.7	P	0.84	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10683	10683	G	C	MI.16145	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	214	72	A	P	Gcg/Ccg	-4.32	0	0	probably_damaging	0.97	neutral	0.23	neutral	1.36	deleterious	-5.83	deleterious	-4.75	high_impact	4.27	0.61	neutral	0.29	neutral	3.90	23.50	deleterious	0.24	0.45	0.7	disease	0.94	disease	0.71	disease	0.88	disease	8	0.98	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-2.19	low_impact	-0.08	medium_impact	2.44	high_impact	0.62	0.8	51.02	9.95	0.4	N	0.86	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10683	10683	G	A	MI.16146	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	214	72	A	T	Gcg/Acg	-4.32	0	0	probably_damaging	0.95	neutral	0.45	neutral	1.41	deleterious	-3.76	deleterious	-3.82	medium_impact	3.3	0.73	neutral	0.48	neutral	4.22	23.90	deleterious	0.45	0.55	0.5	neutral	0.67	disease	0.59	disease	0.72	disease	4	0.95	neutral	0.25	neutral	1	deleterious	0.75	deleterious	-1.97	low_impact	0.16	medium_impact	1.63	medium_impact	0.69	0.85	51.02	9.95	0.38	N	0.76	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10683	10683	G	T	MI.16147	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	214	72	A	S	Gcg/Tcg	-4.32	0	0	possibly_damaging	0.78	neutral	1	neutral	1.61	neutral	-1.52	deleterious	-2.76	low_impact	1.83	0.65	neutral	0.59	neutral	1.66	14.20	neutral	0.49	0.55	0.21	neutral	0.25	neutral	0.25	neutral	0.44	neutral	1	0.78	neutral	0.61	deleterious	-3	neutral	0.60	deleterious	-1.31	low_impact	1.88	high_impact	0.4	medium_impact	0.69	0.85	51.02	9.95	0.34	N	0.53	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10684	10684	C	T	MI.16148	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	215	72	A	V	gCg/gTg	1.91	0.98	0	probably_damaging	0.94	neutral	0.48	neutral	1.47	neutral	-2.65	deleterious	-3.9	medium_impact	2.7	0.74	neutral	0.5	neutral	4.45	24.20	deleterious	0.48	0.55	0.63	disease	0.8	disease	0.52	disease	0.71	disease	4	0.94	neutral	0.27	neutral	1	deleterious	0.79	deleterious	-1.9	low_impact	0.19	medium_impact	1.13	medium_impact	0.58	0.8	51.02	9.95	0.5	N	0.87	disease_causing	0.88	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10684	10684	C	G	MI.16149	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	215	72	A	G	gCg/gGg	1.91	0.98	0	benign	0.1	neutral	0.61	neutral	1.44	deleterious	-3.04	deleterious	-3.26	low_impact	1.31	0.8	neutral	0.9	neutral	0.10	3.58	deleterious	0.4	0.5	0.28	neutral	0.48	neutral	0.35	neutral	0.46	neutral	1	0.3	neutral	0.76	deleterious	-6	neutral	0.20	neutral	0.07	medium_impact	0.32	medium_impact	-0.04	medium_impact	0.76	0.85	51.02	9.95	0.44	N	0.44	disease_causing	0.86	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8447	8447	A	G	MI.1615	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	82	28	M	V	Ata/Gta	1.29	0.55	0	benign	0	neutral	1	neutral	1.29	neutral	-2.13	neutral	0.09	low_impact	1.27	1	neutral	0.97	neutral	-1.04	0.01	neutral	0.75275300	0.85	0.12	neutral	0.08	neutral	0.57	disease	0.04	neutral	9	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.98	high_impact	-0.01	medium_impact	0.46	0.85	4.41	9.71	0.35	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10684	10684	C	A	MI.16150	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	215	72	A	E	gCg/gAg	1.91	0.98	0	probably_damaging	0.97	neutral	0.71	neutral	1.37	deleterious	-4.86	deleterious	-4.75	high_impact	3.92	0.73	neutral	0.39	neutral	4.58	24.40	deleterious	0.17	0.45	0.69	disease	0.9	disease	0.69	disease	0.8	disease	6	0.97	neutral	0.37	neutral	2	deleterious	0.85	deleterious	-2.19	low_impact	0.43	medium_impact	2.15	high_impact	0.61	0.8	51.02	9.95	0.54	N	0.93	disease_causing	0.93	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10686	10686	G	A	MI.16151	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	217	73	V	M	Gtg/Atg	-8.7	0	0	possibly_damaging	0.68	neutral	0.21	neutral	1.79	neutral	-2.49	neutral	-2.01	low_impact	1.92	0.8	neutral	0.71	neutral	2.37	18.63	deleterious	0.59	0.65	0.43	neutral	0.51	disease	0.32	neutral	0.49	neutral	0	0.82	neutral	0.27	neutral	-3	neutral	0.47	deleterious	-1.1	low_impact	-0.11	medium_impact	0.47	medium_impact	0.97	1	28.57	22.97	0.34	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	COSM488727	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10686	10686	G	T	MI.16152	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	217	73	V	L	Gtg/Ttg	-8.7	0	0	possibly_damaging	0.54	neutral	1	neutral	2.08	neutral	0.43	neutral	-1.6	neutral_impact	-0.5	0.82	neutral	0.95	neutral	1.89	15.53	deleterious	0.46	0.55	0.11	neutral	0.54	disease	0.3	neutral	0.43	neutral	1	0.54	neutral	0.73	deleterious	-3	neutral	0.40	neutral	-0.87	medium_impact	1.88	high_impact	-1.56	low_impact	0.66	0.8	28.57	22.97	0.24	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10686	10686	G	C	MI.16153	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	217	73	V	L	Gtg/Ctg	-8.7	0	0	possibly_damaging	0.54	neutral	1	neutral	2.08	neutral	0.43	neutral	-1.6	neutral_impact	-0.5	0.82	neutral	0.95	neutral	1.79	14.96	neutral	0.46	0.55	0.11	neutral	0.54	disease	0.3	neutral	0.43	neutral	1	0.54	neutral	0.73	deleterious	-3	neutral	0.40	neutral	-0.87	medium_impact	1.88	high_impact	-1.56	low_impact	0.66	0.8	28.57	22.97	0.23	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10687	10687	T	C	MI.16154	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	218	73	V	A	gTg/gCg	-1.09	0	0	possibly_damaging	0.86	neutral	0.64	neutral	1.82	neutral	-1.72	deleterious	-3.68	low_impact	1.71	0.74	neutral	0.72	neutral	1.59	13.79	neutral	0.46	0.55	0.25	neutral	0.25	neutral	0.33	neutral	0.43	neutral	1	0.83	neutral	0.39	neutral	-3	neutral	0.56	deleterious	-1.53	low_impact	0.35	medium_impact	0.3	medium_impact	0.50	0.8	28.57	22.97	0.36	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10687	10687	T	G	MI.16155	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	218	73	V	G	gTg/gGg	-1.09	0	0	probably_damaging	0.98	neutral	0.44	neutral	1.76	deleterious	-4.01	deleterious	-6.64	medium_impact	3.36	0.77	neutral	0.48	neutral	3.86	23.50	deleterious	0.27	0.45	0.57	disease	0.82	disease	0.6	disease	0.78	disease	6	0.98	neutral	0.23	neutral	1	deleterious	0.75	deleterious	-2.35	low_impact	0.15	medium_impact	1.68	medium_impact	0.43	0.8	28.57	22.97	0.29	N	0.94	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10687	10687	T	A	MI.16156	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	218	73	V	E	gTg/gAg	-1.09	0	0	probably_damaging	0.98	neutral	0.25	neutral	1.75	deleterious	-4.26	deleterious	-5.64	medium_impact	3.36	0.79	neutral	0.35	neutral	4.74	24.70	deleterious	0.2	0.45	0.57	disease	0.86	disease	0.65	disease	0.81	disease	6	0.98	deleterious	0.14	neutral	1	deleterious	0.80	deleterious	-2.35	low_impact	-0.06	medium_impact	1.68	medium_impact	0.41	0.8	28.57	22.97	0.31	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10689	10689	G	C	MI.16157	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	220	74	G	R	Ggc/Cgc	-8.7	0	0	probably_damaging	1	neutral	0.35	neutral	1.54	deleterious	-8.93	deleterious	-7.96	high_impact	4.75	0.58	damaging	0.06	damaging	3.94	23.50	deleterious	0.14	0.4	0.92	disease	0.96	disease	0.83	disease	0.92	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.06	medium_impact	2.84	high_impact	0.69	0.85	54.08	12.29	0.54	P	0.99	disease_causing	0.96	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10689	10689	G	A	MI.16158	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	220	74	G	S	Ggc/Agc	-8.7	0	0	probably_damaging	1	neutral	0.43	neutral	1.57	deleterious	-7.5	deleterious	-5.97	high_impact	4.41	0.56	damaging	0.06	damaging	4.22	23.90	deleterious	0.2	0.45	0.82	disease	0.95	disease	0.72	disease	0.85	disease	7	1	deleterious	0.22	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.14	medium_impact	2.56	high_impact	0.81	0.85	54.08	12.29	0.41	N	0.97	disease_causing	0.92	0.32	rs879102108	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10689	10689	G	T	MI.16159	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	220	74	G	C	Ggc/Tgc	-8.7	0	0	probably_damaging	1	neutral	0.18	neutral	1.55	deleterious	-9.67	deleterious	-8.96	high_impact	4.21	0.55	damaging	0.03	damaging	4.13	23.80	deleterious	0.14	0.4	0.94	disease	0.96	disease	0.76	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	-0.16	medium_impact	2.39	high_impact	0.49	0.8	54.08	12.29	0.37	N	1.00	disease_causing	0.98	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8447	8447	A	C	MI.1616	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	82	28	M	L	Ata/Cta	1.29	0.55	0	benign	0	neutral	0.76	neutral	1.64	neutral	0.2	neutral	0.32	neutral_impact	-0.12	1	neutral	0.95	neutral	-1.57	0.00	neutral	0.68116519	0.85	0.15	neutral	0.06	neutral	0.48	neutral	0.03	neutral	9	0.24	neutral	0.88	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	0.57	medium_impact	-1.2	low_impact	0.62	0.85	4.41	9.71	0.34	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10690	10690	G	T	MI.16160	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	221	74	G	V	gGc/gTc	6.06	1	0	probably_damaging	1	neutral	0.52	neutral	1.73	deleterious	-8.73	deleterious	-8.96	high_impact	4.75	0.53	damaging	0.03	damaging	3.87	23.50	deleterious	0.12	0.4	0.91	disease	0.96	disease	0.75	disease	0.85	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.23	medium_impact	2.84	high_impact	0.51	0.8	54.08	12.29	0.58	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10690	10690	G	C	MI.16161	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	221	74	G	A	gGc/gCc	6.06	1	0	probably_damaging	1	neutral	0.52	neutral	1.65	deleterious	-7.22	deleterious	-5.97	high_impact	3.86	0.63	neutral	0.06	damaging	3.17	22.70	deleterious	0.24	0.45	0.79	disease	0.9	disease	0.72	disease	0.8	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0.23	medium_impact	2.1	high_impact	0.50	0.8	54.08	12.29	0.58	P	0.98	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10690	10690	G	A	MI.16162	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	221	74	G	D	gGc/gAc	6.06	1	0	probably_damaging	1	neutral	0.21	neutral	1.53	deleterious	-8.38	deleterious	-6.97	high_impact	4.75	0.58	damaging	0.03	damaging	3.84	23.40	deleterious	0.08	0.35	0.89	disease	0.97	disease	0.83	disease	0.92	disease	8	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.11	medium_impact	2.84	high_impact	0.40	0.8	54.08	12.29	0.69	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10692	10692	C	G	MI.16163	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	223	75	L	V	Cta/Gta	-13.54	0	0.01	probably_damaging	1	neutral	0.4	neutral	0.36	deleterious	-5.01	deleterious	-2.99	high_impact	4.07	0.46	damaging	0.05	damaging	3.49	23.10	deleterious	0.3	0.45	0.27	neutral	0.75	disease	0.69	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.73	deleterious	-3.55	low_impact	0.11	medium_impact	2.27	high_impact	0.66	0.8	54.08	12.39	0.32	N	0.75	disease_causing	0.62	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10692	10692	C	A	MI.16164	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	223	75	L	M	Cta/Ata	-13.54	0	0.01	probably_damaging	1	neutral	0.09	neutral	0.29	deleterious	-6.61	neutral	-1.99	high_impact	4.42	0.5	damaging	0.04	damaging	3.80	23.40	deleterious	0.25	0.45	0.57	disease	0.76	disease	0.72	disease	0.74	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.77	deleterious	-3.55	low_impact	-0.35	medium_impact	2.57	high_impact	0.63	0.8	54.08	12.39	0.38	N	0.77	disease_causing	0.57	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10693	10693	T	C	MI.16165	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	224	75	L	P	cTa/cCa	-0.63	0	0	probably_damaging	1	neutral	0.06	neutral	0.26	deleterious	-9.32	deleterious	-6.97	high_impact	4.42	0.4	damaging	0.02	damaging	3.95	23.60	deleterious	0.17	0.45	0.89	disease	0.93	disease	0.81	disease	0.9	disease	8	1	deleterious	0.03	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.45	medium_impact	2.57	high_impact	0.40	0.8	54.08	12.39	0.55	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10693	10693	T	G	MI.16166	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	224	75	L	R	cTa/cGa	-0.63	0	0	probably_damaging	1	neutral	0.16	neutral	0.27	deleterious	-8.91	deleterious	-5.97	high_impact	4.76	0.45	damaging	0.02	damaging	4.24	23.90	deleterious	0.15	0.4	0.86	disease	0.93	disease	0.81	disease	0.91	disease	8	1	deleterious	0.08	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	-0.19	medium_impact	2.85	high_impact	0.55	0.8	54.08	12.39	0.55	P	0.99	polymorphism	0.99	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10693	10693	T	A	MI.16167	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	224	75	L	Q	cTa/cAa	-0.63	0	0	probably_damaging	1	neutral	0.09	neutral	0.27	deleterious	-8.91	deleterious	-5.97	high_impact	4.76	0.45	damaging	0.02	damaging	4.13	23.80	deleterious	0.16	0.45	0.86	disease	0.93	disease	0.74	disease	0.84	disease	7	1	deleterious	0.05	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	-0.35	medium_impact	2.85	high_impact	0.65	0.8	54.08	12.39	0.53	P	0.99	polymorphism	0.99	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10695	10695	G	C	MI.16168	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	226	76	A	P	Gcc/Ccc	-2.94	0	0	probably_damaging	0.96	neutral	0.19	neutral	1.59	deleterious	-5.23	deleterious	-4.53	high_impact	4.02	0.57	damaging	0.29	neutral	3.83	23.40	deleterious	0.18	0.45	0.64	disease	0.96	disease	0.74	disease	0.89	disease	8	0.98	neutral	0.12	neutral	2	deleterious	0.87	deleterious	-2.07	low_impact	-0.14	medium_impact	2.23	high_impact	0.65	0.8	25.51	16.97	0.4	N	0.91	polymorphism	0.8	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10695	10695	G	T	MI.16169	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	226	76	A	S	Gcc/Tcc	-2.94	0	0	benign	0.3	neutral	0.73	neutral	1.78	neutral	-1.6	neutral	-2.08	neutral_impact	0.02	0.8	neutral	0.92	neutral	0.89	10.01	neutral	0.53	0.6	0.12	neutral	0.75	disease	0.29	neutral	0.52	disease	0	0.22	neutral	0.72	deleterious	-6	neutral	0.28	neutral	-0.47	medium_impact	0.45	medium_impact	-1.12	low_impact	0.85	0.9	25.51	16.97	0.21	N	0.04	polymorphism	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8447	8447	A	T	MI.1617	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	82	28	M	L	Ata/Tta	1.29	0.55	0	benign	0	neutral	0.76	neutral	1.64	neutral	0.2	neutral	0.32	neutral_impact	-0.12	1	neutral	0.95	neutral	-1.50	0.00	neutral	0.68116519	0.85	0.15	neutral	0.06	neutral	0.48	neutral	0.03	neutral	9	0.24	neutral	0.88	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	0.57	medium_impact	-1.2	low_impact	0.62	0.85	4.41	9.71	0.34	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10695	10695	G	A	MI.16170	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	226	76	A	T	Gcc/Acc	-2.94	0	0	possibly_damaging	0.86	neutral	0.39	neutral	1.75	deleterious	-3.75	deleterious	-3.38	medium_impact	2.6	0.72	neutral	0.66	neutral	4.25	23.90	deleterious	0.4	0.5	0.43	neutral	0.89	disease	0.58	disease	0.71	disease	4	0.86	neutral	0.27	neutral	0	NA	0.74	deleterious	-1.53	low_impact	0.1	medium_impact	1.04	medium_impact	0.77	0.85	25.51	16.97	0.41	N	0.72	polymorphism	0.93	0.10	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10696	10696	C	A	MI.16171	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	227	76	A	D	gCc/gAc	1.21	0.76	0	probably_damaging	0.93	neutral	0.19	neutral	1.6	deleterious	-5.19	deleterious	-5.22	high_impact	4.02	0.64	neutral	0.31	neutral	4.62	24.50	deleterious	0.14	0.4	0.66	disease	0.97	disease	0.72	disease	0.88	disease	8	0.96	neutral	0.13	neutral	2	deleterious	0.86	deleterious	-1.83	low_impact	-0.14	medium_impact	2.23	high_impact	0.67	0.85	25.51	16.97	0.42	N	0.93	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10696	10696	C	T	MI.16172	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	227	76	A	V	gCc/gTc	1.21	0.76	0	possibly_damaging	0.9	neutral	0.58	neutral	1.75	deleterious	-4.59	deleterious	-3.83	medium_impact	3.47	0.72	neutral	0.54	neutral	4.44	24.20	deleterious	0.49	0.55	0.57	disease	0.9	disease	0.64	disease	0.74	disease	5	0.88	neutral	0.34	neutral	0	NA	0.78	deleterious	-1.68	low_impact	0.29	medium_impact	1.77	medium_impact	0.79	0.85	25.51	16.97	0.41	N	0.83	disease_causing	0.99	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10696	10696	C	G	MI.16173	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	227	76	A	G	gCc/gGc	1.21	0.76	0	possibly_damaging	0.78	neutral	0.48	neutral	1.66	deleterious	-3.3	deleterious	-3.53	medium_impact	2.41	0.69	neutral	0.62	neutral	3.87	23.50	deleterious	0.38	0.5	0.22	neutral	0.9	disease	0.56	disease	0.59	disease	2	0.77	neutral	0.35	neutral	0	NA	0.66	deleterious	-1.31	low_impact	0.19	medium_impact	0.88	medium_impact	0.81	0.85	25.51	16.97	0.34	N	0.50	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10698	10698	C	A	MI.16174	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	229	77	L	M	Cta/Ata	-10.78	0	0	probably_damaging	1	neutral	0.18	neutral	1.32	neutral	-2.9	neutral	-1.92	medium_impact	3.17	0.77	neutral	0.24	damaging	2.66	20.60	deleterious	0.28	0.45	0.38	neutral	0.59	disease	0.53	disease	0.46	neutral	1	1	deleterious	0.09	neutral	1	deleterious	0.72	deleterious	-3.55	low_impact	-0.16	medium_impact	1.52	medium_impact	0.61	0.8	54.08	12.38	0.34	N	0.77	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10698	10698	C	G	MI.16175	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	229	77	L	V	Cta/Gta	-10.78	0	0	probably_damaging	1	neutral	0.22	neutral	1.4	neutral	-1.65	deleterious	-2.92	medium_impact	2.82	0.69	neutral	0.06	damaging	3.49	23.10	deleterious	0.26	0.45	0.41	neutral	0.72	disease	0.56	disease	0.65	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	-0.1	medium_impact	1.23	medium_impact	0.69	0.85	54.08	12.38	0.26	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10699	10699	T	C	MI.16176	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	230	77	L	P	cTa/cCa	-1.78	0	0	probably_damaging	1	deleterious	0.03	neutral	1.26	deleterious	-6.17	deleterious	-6.87	high_impact	4.45	0.56	damaging	0.05	damaging	3.95	23.60	deleterious	0.15	0.45	0.89	disease	0.93	disease	0.72	disease	0.83	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.91	deleterious	-3.55	low_impact	-0.63	medium_impact	2.59	high_impact	0.55	0.8	54.08	12.38	0.38	N	1.00	disease_causing	0.52	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10699	10699	T	G	MI.16177	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	230	77	L	R	cTa/cGa	-1.78	0	0	probably_damaging	1	neutral	0.05	neutral	1.27	deleterious	-5.74	deleterious	-5.87	high_impact	4.45	0.57	damaging	0.05	damaging	4.25	23.90	deleterious	0.1	0.4	0.87	disease	0.92	disease	0.72	disease	0.83	disease	7	1	deleterious	0.03	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	-0.5	medium_impact	2.59	high_impact	0.38	0.8	54.08	12.38	0.4	N	0.99	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10699	10699	T	A	MI.16178	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	230	77	L	Q	cTa/cAa	-1.78	0	0	probably_damaging	1	deleterious	0.04	neutral	1.27	deleterious	-5.72	deleterious	-5.87	high_impact	4.45	0.68	neutral	0.06	damaging	4.11	23.70	deleterious	0.14	0.4	0.86	disease	0.9	disease	0.62	disease	0.8	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-3.55	low_impact	-0.56	medium_impact	2.59	high_impact	0.55	0.8	54.08	12.38	0.37	N	0.99	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10701	10701	C	A	MI.16179	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	232	78	L	M	Cta/Ata	-5.7	0	0	probably_damaging	1	neutral	0.19	neutral	1.62	deleterious	-3.61	neutral	-1.99	medium_impact	2.65	0.75	neutral	0.32	neutral	2.75	21.10	deleterious	0.26	0.45	0.37	neutral	0.39	neutral	0.42	neutral	0.43	neutral	1	1	deleterious	0.1	neutral	1	deleterious	0.71	deleterious	-3.55	low_impact	-0.14	medium_impact	1.08	medium_impact	0.62	0.8	53.06	12.16	0.39	N	0.77	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8448	8448	T	C	MI.1618	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	83	28	M	T	aTa/aCa	-1.26	0	0.01	benign	0	neutral	0.31	neutral	1.22	deleterious	-3.78	neutral	-2.27	neutral_impact	0.7	1	neutral	0.87	neutral	-0.32	0.59	neutral	0.69564761	0.85	0.44	neutral	0.06	neutral	0.64	disease	0.04	neutral	9	0.69	neutral	0.66	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	0.1	medium_impact	-0.5	medium_impact	0.38	0.85	4.41	9.71	0.45	N	0.28	polymorphism	1	0.04	rs879056797	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10701	10701	C	G	MI.16180	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	232	78	L	V	Cta/Gta	-5.7	0	0	probably_damaging	1	neutral	0.33	neutral	1.69	deleterious	-3.03	deleterious	-2.98	medium_impact	3.46	0.74	neutral	0.19	damaging	3.50	23.10	deleterious	0.26	0.45	0.21	neutral	0.7	disease	0.52	disease	0.56	disease	1	1	deleterious	0.17	neutral	1	deleterious	0.72	deleterious	-3.55	low_impact	0.04	medium_impact	1.76	medium_impact	0.64	0.8	53.06	12.16	0.34	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10702	10702	T	C	MI.16181	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	233	78	L	P	cTa/cCa	-1.09	0	0	probably_damaging	1	deleterious	0.04	neutral	1.55	deleterious	-7.29	deleterious	-6.96	high_impact	4.66	0.59	damaging	0.06	damaging	4.02	23.60	deleterious	0.13	0.4	0.72	disease	0.93	disease	0.76	disease	0.87	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-3.55	low_impact	-0.56	medium_impact	2.77	high_impact	0.47	0.8	53.06	12.16	0.47	N	1.00	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10702	10702	T	A	MI.16182	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	233	78	L	Q	cTa/cAa	-1.09	0	0	probably_damaging	1	neutral	0.12	neutral	1.55	deleterious	-6.77	deleterious	-5.97	high_impact	4.66	0.62	neutral	0.06	damaging	4.42	24.20	deleterious	0.15	0.4	0.63	disease	0.9	disease	0.67	disease	0.77	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	-0.27	medium_impact	2.77	high_impact	0.46	0.8	53.06	12.16	0.44	N	0.99	disease_causing	0.5	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10702	10702	T	G	MI.16183	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	233	78	L	R	cTa/cGa	-1.09	0	0	probably_damaging	1	neutral	0.17	neutral	1.55	deleterious	-6.85	deleterious	-5.97	high_impact	4.66	0.58	damaging	0.05	damaging	4.27	23.90	deleterious	0.13	0.4	0.62	disease	0.92	disease	0.77	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.17	medium_impact	2.77	high_impact	0.38	0.8	53.06	12.16	0.5	N	0.99	disease_causing	0.56	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10704	10704	G	A	MI.16184	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	235	79	V	I	Gtc/Atc	-0.17	0.77	0	benign	0.03	neutral	0.23	neutral	1.66	neutral	-1.88	neutral	-0.79	medium_impact	2.69	0.85	neutral	0.83	neutral	0.66	8.56	deleterious	0.54	0.6	0.44	neutral	0.74	disease	0.44	neutral	0.54	disease	1	0.76	neutral	0.6	deleterious	-3	neutral	0.23	neutral	0.58	medium_impact	-0.08	medium_impact	1.12	medium_impact	0.87	0.9	20.41	12.27	0.33	N	0.03	disease_causing	0.93	0.06	rs28437034	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10704	10704	G	C	MI.16185	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	235	79	V	L	Gtc/Ctc	-0.17	0.77	0	benign	0.28	neutral	0.5	neutral	1.64	neutral	-2.31	deleterious	-2.7	high_impact	4.23	0.67	neutral	0.42	neutral	1.74	14.64	neutral	0.32	0.5	0.52	disease	0.92	disease	0.64	disease	0.75	disease	5	0.4	neutral	0.61	deleterious	-2	neutral	0.35	neutral	-0.43	medium_impact	0.21	medium_impact	2.41	high_impact	0.53	0.8	20.41	12.27	0.36	N	0.57	disease_causing	0.98	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10704	10704	G	T	MI.16186	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	235	79	V	F	Gtc/Ttc	-0.17	0.77	0	benign	0.11	neutral	0.2	neutral	1.53	deleterious	-4.24	deleterious	-4.65	high_impact	4.58	0.69	neutral	0.44	neutral	3.52	23.10	deleterious	0.13	0.4	0.75	disease	0.97	disease	0.71	disease	0.85	disease	7	0.77	neutral	0.55	deleterious	-2	neutral	0.34	neutral	0.03	medium_impact	-0.12	medium_impact	2.7	high_impact	0.48	0.8	20.41	12.27	0.49	N	0.83	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10705	10705	T	C	MI.16187	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	236	79	V	A	gTc/gCc	5.13	1	0	benign	0.05	neutral	0.23	neutral	1.56	deleterious	-3.42	deleterious	-3.67	medium_impact	2.56	0.8	neutral	0.83	neutral	0.67	8.60	deleterious	0.28	0.45	0.48	neutral	0.83	disease	0.62	disease	0.57	disease	1	0.75	neutral	0.59	deleterious	-3	neutral	0.27	neutral	0.37	medium_impact	-0.08	medium_impact	1.01	medium_impact	0.33	0.8	20.41	12.27	0.54	N	0.23	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10705	10705	T	G	MI.16188	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	236	79	V	G	gTc/gGc	5.13	1	0	possibly_damaging	0.74	neutral	0.23	neutral	1.5	deleterious	-5.24	deleterious	-6.69	high_impact	4.58	0.68	neutral	0.47	neutral	2.24	17.78	deleterious	0.09	0.35	0.66	disease	0.94	disease	0.7	disease	0.84	disease	7	0.84	neutral	0.25	neutral	1	deleterious	0.60	deleterious	-1.22	low_impact	-0.08	medium_impact	2.7	high_impact	0.36	0.8	20.41	12.27	0.67	P	0.92	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10705	10705	T	A	MI.16189	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	236	79	V	D	gTc/gAc	5.13	1	0	possibly_damaging	0.89	neutral	0.05	neutral	1.49	deleterious	-5.88	deleterious	-6.66	high_impact	4.58	0.71	neutral	0.33	neutral	4.57	24.40	deleterious	0.06	0.35	0.81	disease	0.97	disease	0.79	disease	0.9	disease	8	0.98	neutral	0.08	neutral	1	deleterious	0.75	deleterious	-1.64	low_impact	-0.5	medium_impact	2.7	high_impact	0.37	0.8	20.41	12.27	0.68	P	0.96	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8448	8448	T	A	MI.1619	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	83	28	M	K	aTa/aAa	-1.26	0	0.01	benign	0.01	neutral	0.21	neutral	1.22	deleterious	-3.83	deleterious	-3.86	medium_impact	2.63	0.99	neutral	0.45	neutral	2.18	17.40	deleterious	0.29985770	0.85	0.66	disease	0.29	neutral	0.78	disease	0.23	neutral	5	0.79	neutral	0.6	deleterious	-3	neutral	0.26	neutral	1.14	medium_impact	-0.03	medium_impact	1.16	medium_impact	0.32	0.85	4.41	9.71	0.51	N	0.71	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10707	10707	T	G	MI.16190	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	238	80	S	A	Tca/Gca	-8.01	0	0	benign	0.36	neutral	0.71	neutral	2.07	neutral	0.61	neutral	-0.49	neutral_impact	0.54	0.61	neutral	0.81	neutral	0.96	10.41	neutral	0.45	0.55	0.12	neutral	0.14	neutral	0.16	neutral	0.27	neutral	5	0.27	neutral	0.68	deleterious	-6	neutral	0.48	deleterious	-0.57	medium_impact	0.43	medium_impact	-0.69	medium_impact	0.75	0.85	29.59	21.89	0.45	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10707	10707	T	A	MI.16191	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	238	80	S	T	Tca/Aca	-8.01	0	0	benign	0.36	neutral	0.43	neutral	1.93	neutral	-1.09	neutral	-0.36	low_impact	0.86	0.75	neutral	0.96	neutral	0.97	10.51	neutral	0.41	0.5	0.22	neutral	0.42	neutral	0.28	neutral	0.45	neutral	1	0.5	neutral	0.54	deleterious	-6	neutral	0.60	deleterious	-0.57	medium_impact	0.14	medium_impact	-0.42	medium_impact	0.84	0.9	29.59	21.89	0.44	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10707	10707	T	C	MI.16192	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	238	80	S	P	Tca/Cca	-8.01	0	0	probably_damaging	0.91	neutral	0.2	neutral	1.88	neutral	-2.93	neutral	-1.51	medium_impact	3.22	0.44	damaging	0.36	neutral	4.02	23.60	deleterious	0.17	0.45	0.4	neutral	0.93	disease	0.68	disease	0.84	disease	7	0.94	neutral	0.15	neutral	1	deleterious	0.81	deleterious	-1.72	low_impact	-0.12	medium_impact	1.56	medium_impact	0.74	0.85	29.59	21.89	0.45	N	0.66	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10708	10708	C	G	MI.16193	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	239	80	S	W	tCa/tGa	3.29	0.21	0	probably_damaging	0.95	neutral	0.17	neutral	1.86	deleterious	-5.08	neutral	-1.39	medium_impact	3.22	0.58	damaging	0.41	neutral	4.42	24.20	deleterious	0.16	0.45	0.74	disease	0.89	disease	0.62	disease	0.82	disease	6	0.97	neutral	0.11	neutral	1	deleterious	0.83	deleterious	-1.97	low_impact	-0.17	medium_impact	1.56	medium_impact	0.51	0.8	29.59	21.89	0.44	N	0.61	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10708	10708	C	T	MI.16194	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	239	80	S	L	tCa/tTa	3.29	0.21	0	benign	0.01	neutral	0.75	neutral	1.93	neutral	-1.01	neutral	1.14	low_impact	1.61	0.75	neutral	0.87	neutral	3.57	23.20	deleterious	0.37	0.5	0.29	neutral	0.81	disease	0.46	neutral	0.69	disease	4	0.22	neutral	0.87	deleterious	-6	neutral	0.21	neutral	1.03	medium_impact	0.48	medium_impact	0.21	medium_impact	0.84	0.9	29.59	21.89	0.31	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10710	10710	A	C	MI.16195	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	241	81	I	L	Atc/Ctc	-0.86	0	0	possibly_damaging	0.61	neutral	0.74	neutral	2.04	neutral	0.23	neutral	-1.75	neutral_impact	0.64	0.73	neutral	0.18	damaging	2.68	20.70	deleterious	0.47	0.55	0.14	neutral	0.76	disease	0.22	neutral	0.61	disease	2	0.53	neutral	0.57	deleterious	-3	neutral	0.52	deleterious	-0.98	medium_impact	0.46	medium_impact	-0.6	medium_impact	0.65	0.8	24.49	13.82	0.28	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10710	10710	A	G	MI.16196	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	241	81	I	V	Atc/Gtc	-0.86	0	0	benign	0.18	neutral	0.6	neutral	2.05	neutral	0.3	neutral	0.08	neutral_impact	-0.04	0.81	neutral	0.95	neutral	0.75	9.17	deleterious	0.75	0.8	0.13	neutral	0.42	neutral	0.24	neutral	0.44	neutral	1	0.28	neutral	0.71	deleterious	-6	neutral	0.52	deleterious	-0.2	medium_impact	0.31	medium_impact	-1.17	low_impact	0.47	0.8	24.49	13.82	0.27	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10710	10710	A	T	MI.16197	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	241	81	I	F	Atc/Ttc	-0.86	0	0	benign	0.33	neutral	0.71	neutral	1.83	neutral	-2.2	deleterious	-3.47	low_impact	1.64	0.73	neutral	0.22	damaging	1.15	11.46	neutral	0.52	0.6	0.27	neutral	0.87	disease	0.42	neutral	0.77	disease	5	0.24	neutral	0.69	deleterious	-6	neutral	0.26	neutral	-0.52	medium_impact	0.43	medium_impact	0.24	medium_impact	0.70	0.85	24.49	13.82	0.22	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10711	10711	T	A	MI.16198	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	242	81	I	N	aTc/aAc	0.06	0	0	probably_damaging	0.99	neutral	0.42	neutral	1.8	deleterious	-3.4	deleterious	-6.05	medium_impact	2.86	0.73	neutral	0.18	damaging	4.72	24.60	deleterious	0.45	0.55	0.37	neutral	0.91	disease	0.53	disease	0.8	disease	6	0.99	deleterious	0.22	neutral	1	deleterious	0.79	deleterious	-2.63	low_impact	0.13	medium_impact	1.26	medium_impact	0.53	0.8	24.49	13.82	0.27	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10711	10711	T	C	MI.16199	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	242	81	I	T	aTc/aCc	0.06	0	0	probably_damaging	0.91	neutral	0.59	neutral	1.91	neutral	-0.77	deleterious	-3.6	neutral_impact	0.32	0.75	neutral	0.93	neutral	0.83	9.65	deleterious	0.6	0.65	0.14	neutral	0.24	neutral	0.19	neutral	0.42	neutral	2	0.9	neutral	0.34	neutral	-2	neutral	0.64	deleterious	-1.72	low_impact	0.3	medium_impact	-0.87	medium_impact	0.56	0.8	24.49	13.82	0.35	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8602	8602	T	A	MI.162	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	76	26	F	I	Ttt/Att	-2.65	0	0.01	benign	0.06	neutral	0.38	neutral	4.35	neutral	-0.36	neutral	-2.41	neutral_impact	0.15	0.83	neutral	0.72	neutral	1.08	11.09	neutral	0.29	0.65	0.42	neutral	0.32	neutral	0.3	neutral	0.47	neutral	1	0.58	neutral	0.66	deleterious	-6	neutral	0.18	neutral	0.38	medium_impact	0.17	medium_impact	-0.97	medium_impact	0.44	0.9	15.49	8.03	0.32	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8449	8449	A	T	MI.1620	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	84	28	M	I	atA/atT	2.9	0.49	0	benign	0	neutral	0.77	neutral	1.36	neutral	-1.3	neutral	0.52	neutral_impact	-0.09	0.98	neutral	0.97	neutral	-0.71	0.07	neutral	0.69199839	0.85	0.11	neutral	0.06	neutral	0.47	neutral	0.03	neutral	9	0.23	neutral	0.89	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	0.59	medium_impact	-1.18	low_impact	0.57	0.85	4.41	9.71	0.4	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10711	10711	T	G	MI.16200	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	242	81	I	S	aTc/aGc	0.06	0	0	probably_damaging	0.96	neutral	0.64	neutral	1.86	neutral	-1.41	deleterious	-5.05	low_impact	1.68	0.73	neutral	0.52	neutral	2.69	20.70	deleterious	0.43	0.55	0.17	neutral	0.78	disease	0.31	neutral	0.56	disease	1	0.95	neutral	0.34	neutral	-2	neutral	0.70	deleterious	-2.07	low_impact	0.35	medium_impact	0.27	medium_impact	0.58	0.8	24.49	13.82	0.24	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10712	10712	C	G	MI.16201	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	243	81	I	M	atC/atG	4.21	0.27	0	probably_damaging	0.98	neutral	0.28	neutral	1.87	neutral	-1.3	neutral	-2.01	low_impact	0.94	0.79	neutral	0.77	neutral	2.34	18.46	deleterious	0.62	0.65	0.11	neutral	0.67	disease	0.18	neutral	0.46	neutral	1	0.98	deleterious	0.15	neutral	-2	neutral	0.66	deleterious	-2.35	low_impact	-0.02	medium_impact	-0.35	medium_impact	0.74	0.85	24.49	13.82	0.4	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10712	10712	C	A	MI.16202	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	243	81	I	M	atC/atA	4.21	0.27	0	probably_damaging	0.98	neutral	0.28	neutral	1.87	neutral	-1.3	neutral	-2.01	low_impact	0.94	0.79	neutral	0.77	neutral	2.75	21.10	deleterious	0.62	0.65	0.11	neutral	0.67	disease	0.18	neutral	0.46	neutral	1	0.98	deleterious	0.15	neutral	-2	neutral	0.66	deleterious	-2.35	low_impact	-0.02	medium_impact	-0.35	medium_impact	0.74	0.85	24.49	13.82	0.41	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10713	10713	T	A	MI.16203	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	244	82	S	T	Tcc/Acc	-13.08	0	0	probably_damaging	0.92	neutral	0.41	neutral	1.88	neutral	-1.52	deleterious	-2.88	medium_impact	2.05	0.73	neutral	0.27	damaging	2.23	17.73	deleterious	0.5	0.6	0.28	neutral	0.35	neutral	0.23	neutral	0.46	neutral	1	0.92	neutral	0.25	neutral	1	deleterious	0.64	deleterious	-1.78	low_impact	0.12	medium_impact	0.58	medium_impact	0.87	0.9	55.1	11.36	0.34	N	0.61	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10713	10713	T	C	MI.16204	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	244	82	S	P	Tcc/Ccc	-13.08	0	0	benign	0.29	neutral	0.2	neutral	1.83	deleterious	-3.68	deleterious	-4.85	high_impact	4.04	0.64	neutral	0.1	damaging	2.28	18.03	deleterious	0.24	0.45	0.53	disease	0.95	disease	0.64	disease	0.84	disease	7	0.76	neutral	0.46	neutral	-2	neutral	0.36	neutral	-0.45	medium_impact	-0.12	medium_impact	2.25	high_impact	0.75	0.85	55.1	11.36	0.33	N	0.85	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10713	10713	T	G	MI.16205	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	244	82	S	A	Tcc/Gcc	-13.08	0	0	possibly_damaging	0.78	neutral	0.52	neutral	1.94	neutral	-0.61	deleterious	-2.88	medium_impact	1.94	0.74	neutral	0.43	neutral	2.10	16.87	deleterious	0.63	0.65	0.14	neutral	0.36	neutral	0.3	neutral	0.45	neutral	1	0.76	neutral	0.37	neutral	0	NA	0.58	deleterious	-1.31	low_impact	0.23	medium_impact	0.49	medium_impact	0.81	0.85	55.1	11.36	0.35	N	0.37	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10714	10714	C	G	MI.16206	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	245	82	S	C	tCc/tGc	1.21	0.8	0	probably_damaging	0.99	neutral	0.17	neutral	1.82	deleterious	-3.95	deleterious	-4.81	high_impact	4.04	0.7	neutral	0.07	damaging	3.68	23.30	deleterious	0.31	0.45	0.55	disease	0.87	disease	0.51	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.78	deleterious	-2.63	low_impact	-0.17	medium_impact	2.25	high_impact	0.70	0.85	55.1	11.36	0.38	N	0.81	polymorphism	0.6	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10714	10714	C	A	MI.16207	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	245	82	S	Y	tCc/tAc	1.21	0.8	0	probably_damaging	0.99	neutral	1	neutral	2.07	neutral	0.5	deleterious	-5.53	medium_impact	2.22	0.77	neutral	0.13	damaging	4.19	23.80	deleterious	0.36	0.5	0.24	neutral	0.9	disease	0.42	neutral	0.73	disease	5	0.99	deleterious	0.51	deleterious	1	deleterious	0.75	deleterious	-2.63	low_impact	1.88	high_impact	0.72	medium_impact	0.76	0.85	55.1	11.36	0.2	N	0.59	disease_causing	0.54	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10714	10714	C	T	MI.16208	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	245	82	S	F	tCc/tTc	1.21	0.8	0	probably_damaging	0.99	neutral	0.7	neutral	1.9	neutral	-1.1	deleterious	-5.55	medium_impact	2.94	0.75	neutral	0.08	damaging	4.35	24.10	deleterious	0.44	0.55	0.36	neutral	0.91	disease	0.53	disease	0.78	disease	6	0.99	deleterious	0.36	neutral	1	deleterious	0.78	deleterious	-2.63	low_impact	0.41	medium_impact	1.33	medium_impact	0.54	0.8	55.1	11.36	0.25	N	0.89	disease_causing	0.67	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10716	10716	A	T	MI.16209	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	247	83	N	Y	Aac/Tac	-11.7	0	0	probably_damaging	0.92	neutral	1	neutral	1.92	neutral	-2.94	deleterious	-7.01	medium_impact	2.72	0.75	neutral	0.35	neutral	3.75	23.30	deleterious	0.54	0.6	0.62	disease	0.87	disease	0.63	disease	0.79	disease	6	0.92	neutral	0.54	deleterious	1	deleterious	0.81	deleterious	-1.78	low_impact	1.88	high_impact	1.14	medium_impact	0.50	0.8	52.04	9.32	0.21	N	0.92	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8449	8449	A	C	MI.1621	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	84	28	M	I	atA/atC	2.9	0.49	0	benign	0	neutral	0.77	neutral	1.36	neutral	-1.3	neutral	0.52	neutral_impact	-0.09	0.98	neutral	0.97	neutral	-0.77	0.05	neutral	0.69199839	0.85	0.11	neutral	0.06	neutral	0.47	neutral	0.03	neutral	9	0.23	neutral	0.89	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	0.59	medium_impact	-1.18	low_impact	0.57	0.85	4.41	9.71	0.4	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10716	10716	A	C	MI.16210	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	247	83	N	H	Aac/Cac	-11.7	0	0	probably_damaging	0.94	neutral	0.55	neutral	1.94	neutral	-1.81	deleterious	-4.38	medium_impact	2.44	0.85	neutral	0.44	neutral	3.05	22.40	deleterious	0.66	0.7	0.5	neutral	0.78	disease	0.55	disease	0.7	disease	4	0.93	neutral	0.31	neutral	1	deleterious	0.77	deleterious	-1.9	low_impact	0.26	medium_impact	0.91	medium_impact	0.48	0.8	52.04	9.32	0.22	N	0.58	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10716	10716	A	G	MI.16211	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	247	83	N	D	Aac/Gac	-11.7	0	0	benign	0.05	neutral	0.24	neutral	1.96	neutral	-1.45	deleterious	-4.07	medium_impact	3.42	0.84	neutral	0.49	neutral	1.96	15.99	deleterious	0.8	0.85	0.37	neutral	0.84	disease	0.62	disease	0.78	disease	6	0.74	neutral	0.6	deleterious	-3	neutral	0.62	deleterious	0.37	medium_impact	-0.07	medium_impact	1.73	medium_impact	0.71	0.85	52.04	9.32	0.38	N	0.87	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10717	10717	A	G	MI.16212	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	248	83	N	S	aAc/aGc	3.06	0.91	0	benign	0.08	neutral	0.53	neutral	2.01	neutral	-1.04	deleterious	-3.9	medium_impact	2.26	0.88	neutral	0.81	neutral	0.18	4.47	deleterious	0.74	0.75	0.31	neutral	0.72	disease	0.5	neutral	0.58	disease	2	0.4	neutral	0.73	deleterious	-3	neutral	0.24	neutral	0.17	medium_impact	0.24	medium_impact	0.76	medium_impact	0.37	0.8	52.04	9.32	0.33	N	0.80	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10717	10717	A	C	MI.16213	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	248	83	N	T	aAc/aCc	3.06	0.91	0	possibly_damaging	0.52	neutral	0.41	neutral	1.97	neutral	-1.21	deleterious	-4.94	low_impact	1.64	0.87	neutral	0.83	neutral	1.79	14.92	neutral	0.7	0.75	0.21	neutral	0.73	disease	0.49	neutral	0.59	disease	2	0.59	neutral	0.45	neutral	-3	neutral	0.52	deleterious	-0.84	medium_impact	0.12	medium_impact	0.24	medium_impact	0.51	0.8	52.04	9.32	0.39	N	0.75	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10717	10717	A	T	MI.16214	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	248	83	N	I	aAc/aTc	3.06	0.91	0	benign	0.11	neutral	0.45	neutral	1.92	neutral	-2.55	deleterious	-7.88	medium_impact	3.42	0.78	neutral	0.57	neutral	2.25	17.83	deleterious	0.53	0.6	0.55	disease	0.88	disease	0.57	disease	0.79	disease	6	0.48	neutral	0.67	deleterious	-3	neutral	0.32	neutral	0.03	medium_impact	0.16	medium_impact	1.73	medium_impact	0.41	0.8	52.04	9.32	0.41	N	0.94	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10718	10718	C	G	MI.16215	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	249	83	N	K	aaC/aaG	2.6	0.91	0	benign	0.12	neutral	0.29	neutral	2.05	neutral	0.46	deleterious	-4.92	medium_impact	2.02	0.78	neutral	0.45	neutral	1.05	10.94	neutral	0.85	0.85	0.21	neutral	0.85	disease	0.54	disease	0.75	disease	5	0.67	neutral	0.59	deleterious	-3	neutral	0.25	neutral	-0.01	medium_impact	-0.01	medium_impact	0.56	medium_impact	0.57	0.8	52.04	9.32	0.34	N	0.84	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10718	10718	C	A	MI.16216	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	249	83	N	K	aaC/aaA	2.6	0.91	0	benign	0.12	neutral	0.29	neutral	2.05	neutral	0.46	deleterious	-4.92	medium_impact	2.02	0.78	neutral	0.45	neutral	1.49	13.28	neutral	0.85	0.85	0.21	neutral	0.85	disease	0.54	disease	0.75	disease	5	0.67	neutral	0.59	deleterious	-3	neutral	0.25	neutral	-0.01	medium_impact	-0.01	medium_impact	0.56	medium_impact	0.57	0.8	52.04	9.32	0.34	N	0.84	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10719	10719	A	C	MI.16217	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	250	84	T	P	Aca/Cca	-6.16	0	0	probably_damaging	0.94	neutral	0.2	neutral	1.81	deleterious	-3.5	deleterious	-4.66	high_impact	4.17	0.61	neutral	0.3	neutral	3.44	23.00	deleterious	0.27	0.45	0.74	disease	0.95	disease	0.79	disease	0.91	disease	8	0.96	neutral	0.13	neutral	2	deleterious	0.84	deleterious	-1.9	low_impact	-0.12	medium_impact	2.36	high_impact	0.59	0.8	24.49	9.28	0.46	N	0.96	polymorphism	0.92	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10719	10719	A	T	MI.16218	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	250	84	T	S	Aca/Tca	-6.16	0	0	possibly_damaging	0.68	neutral	0.43	neutral	1.92	neutral	-0.77	neutral	-2.43	low_impact	0.93	0.81	neutral	0.92	neutral	0.58	7.99	deleterious	0.67	0.7	0.27	neutral	0.83	disease	0.46	neutral	0.58	disease	2	0.69	neutral	0.38	neutral	-3	neutral	0.57	deleterious	-1.1	low_impact	0.14	medium_impact	-0.36	medium_impact	0.68	0.85	24.49	9.28	0.27	N	0.85	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10719	10719	A	G	MI.16219	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	250	84	T	A	Aca/Gca	-6.16	0	0	benign	0.4	neutral	0.49	neutral	1.86	neutral	-1.6	deleterious	-3.56	medium_impact	2.33	0.77	neutral	0.62	neutral	1.79	14.90	neutral	0.79	0.8	0.42	neutral	0.83	disease	0.65	disease	0.6	disease	2	0.45	neutral	0.55	deleterious	-3	neutral	0.43	neutral	-0.64	medium_impact	0.2	medium_impact	0.82	medium_impact	0.68	0.85	24.49	9.28	0.27	N	0.91	polymorphism	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8450	8450	T	A	MI.1622	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	85	29	L	M	Tta/Ata	-13.06	0	0.01	probably_damaging	0.98	neutral	0.22	neutral	-0.16	deleterious	-6.09	neutral	-0.58	medium_impact	2.4	1	neutral	0.57	neutral	2.21	17.57	deleterious	0.46643282	0.85	0.51	disease	0.26	neutral	0.27	neutral	0.24	neutral	5	0.98	deleterious	0.12	neutral	1	deleterious	0.73	deleterious	-2.36	low_impact	-0.02	medium_impact	0.96	medium_impact	0.73	0.85	5.88	10.73	0.53	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10720	10720	C	A	MI.16220	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	251	84	T	K	aCa/aAa	4.44	0.97	0	possibly_damaging	0.81	neutral	0.3	neutral	1.92	neutral	-0.71	deleterious	-4.36	medium_impact	2.98	0.72	neutral	0.51	neutral	2.72	20.90	deleterious	0.42	0.55	0.71	disease	0.95	disease	0.72	disease	0.84	disease	7	0.85	neutral	0.25	neutral	0	NA	0.78	deleterious	-1.38	low_impact	0.01	medium_impact	1.36	medium_impact	0.75	0.85	24.49	9.28	0.55	P	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10720	10720	C	T	MI.16221	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	251	84	T	M	aCa/aTa	4.44	0.97	0	benign	0.2	neutral	0.24	neutral	1.81	deleterious	-3.36	deleterious	-3.96	medium_impact	2.65	0.8	neutral	0.65	neutral	2.29	18.10	deleterious	0.53	0.6	0.84	disease	0.91	disease	0.67	disease	0.77	disease	5	0.72	neutral	0.52	deleterious	-3	neutral	0.34	neutral	-0.25	medium_impact	-0.07	medium_impact	1.08	medium_impact	0.73	0.85	24.49	9.28	0.44	N	0.99	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10722	10722	T	C	MI.16222	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	253	85	Y	H	Tat/Cat	-13.54	0	0	benign	0.4	neutral	0.93	neutral	1.93	neutral	-0.45	deleterious	-4.22	neutral_impact	0.46	0.72	neutral	0.78	neutral	-0.79	0.05	neutral	0.68	0.7	0.11	neutral	0.26	neutral	0.37	neutral	0.39	neutral	2	0.33	neutral	0.77	deleterious	-6	neutral	0.21	neutral	-0.64	medium_impact	0.83	medium_impact	-0.75	medium_impact	0.30	0.8	58.16	10.58	0.3	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10722	10722	T	A	MI.16223	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	253	85	Y	N	Tat/Aat	-13.54	0	0	probably_damaging	0.96	neutral	0.44	neutral	1.81	neutral	-1.92	deleterious	-8.37	medium_impact	2.62	0.7	neutral	0.63	neutral	4.17	23.80	deleterious	0.49	0.55	0.59	disease	0.92	disease	0.6	disease	0.76	disease	5	0.96	neutral	0.24	neutral	1	deleterious	0.82	deleterious	-2.07	low_impact	0.15	medium_impact	1.06	medium_impact	0.23	0.8	58.16	10.58	0.36	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10722	10722	T	G	MI.16224	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	253	85	Y	D	Tat/Gat	-13.54	0	0	probably_damaging	0.98	neutral	0.23	neutral	1.78	neutral	-2.82	deleterious	-9.41	high_impact	3.82	0.6	neutral	0.37	neutral	4.12	23.80	deleterious	0.5	0.6	0.67	disease	0.94	disease	0.67	disease	0.85	disease	7	0.98	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-2.35	low_impact	-0.08	medium_impact	2.06	high_impact	0.31	0.8	58.16	10.58	0.42	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10723	10723	A	C	MI.16225	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	254	85	Y	S	tAt/tCt	2.14	0.98	0	probably_damaging	0.97	neutral	0.41	neutral	1.8	neutral	-2.19	deleterious	-8.48	medium_impact	2.29	0.68	neutral	0.49	neutral	3.75	23.30	deleterious	0.41	0.5	0.49	neutral	0.9	disease	0.62	disease	0.78	disease	6	0.97	neutral	0.22	neutral	1	deleterious	0.80	deleterious	-2.19	low_impact	0.12	medium_impact	0.78	medium_impact	0.30	0.8	58.16	10.58	0.5	N	0.98	disease_causing	0.92	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10723	10723	A	T	MI.16226	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	254	85	Y	F	tAt/tTt	2.14	0.98	0	probably_damaging	0.95	neutral	0.67	neutral	1.79	neutral	-2.48	deleterious	-3.79	medium_impact	2.05	0.7	neutral	0.47	neutral	3.34	22.90	deleterious	0.49	0.55	0.29	neutral	0.88	disease	0.62	disease	0.78	disease	6	0.94	neutral	0.36	neutral	1	deleterious	0.75	deleterious	-1.97	low_impact	0.38	medium_impact	0.58	medium_impact	0.35	0.8	58.16	10.58	0.44	N	0.92	polymorphism	0.53	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10723	10723	A	G	MI.16227	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	254	85	Y	C	tAt/tGt	2.14	0.98	0	probably_damaging	0.99	neutral	0.17	neutral	1.75	deleterious	-4.15	deleterious	-8.62	medium_impact	2.92	0.61	neutral	0.35	neutral	3.50	23.10	deleterious	0.54	0.6	0.25	neutral	0.93	disease	0.68	disease	0.8	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.78	deleterious	-2.63	low_impact	-0.17	medium_impact	1.31	medium_impact	0.11	0.8	58.16	10.58	0.5	N	0.99	disease_causing	0.95	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10725	10725	G	C	MI.16228	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	256	86	G	R	Ggc/Cgc	-5.24	0	0	probably_damaging	0.99	neutral	0.41	neutral	1.49	deleterious	-3.12	deleterious	-7.74	high_impact	4.14	0.68	neutral	0.15	damaging	4.11	23.70	deleterious	0.32	0.5	0.92	disease	0.96	disease	0.73	disease	0.85	disease	7	0.99	deleterious	0.21	neutral	2	deleterious	0.91	deleterious	-2.63	low_impact	0.12	medium_impact	2.33	high_impact	0.76	0.85	55.1	12.5	0.37	N	0.99	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10725	10725	G	T	MI.16229	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	256	86	G	C	Ggc/Tgc	-5.24	0	0	probably_damaging	1	neutral	0.17	neutral	1.42	deleterious	-6.4	deleterious	-8.56	high_impact	4.7	0.7	neutral	0.18	damaging	4.26	23.90	deleterious	0.26	0.45	0.94	disease	0.96	disease	0.67	disease	0.83	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	-0.17	medium_impact	2.8	high_impact	0.58	0.8	55.1	12.5	0.52	N	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8450	8450	T	G	MI.1623	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	85	29	L	V	Tta/Gta	-13.06	0	0.01	possibly_damaging	0.87	neutral	0.5	neutral	-0.12	deleterious	-5.16	neutral	-1.51	medium_impact	2.96	0.98	neutral	0.23	damaging	1.98	16.09	deleterious	0.54903459	0.85	0.32	neutral	0.23	neutral	0.39	neutral	0.15	neutral	7	0.86	neutral	0.32	neutral	0	NA	0.68	deleterious	-1.54	low_impact	0.29	medium_impact	1.44	medium_impact	0.44	0.85	5.88	10.73	0.41	N	0.37	polymorphism	1	0.04	rs28461343	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10725	10725	G	A	MI.16230	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	256	86	G	S	Ggc/Agc	-5.24	0	0	probably_damaging	0.97	neutral	0.47	neutral	1.52	neutral	-2.62	deleterious	-5.79	medium_impact	3.31	0.74	neutral	0.38	neutral	4.37	24.10	deleterious	0.35	0.5	0.82	disease	0.91	disease	0.56	disease	0.61	disease	2	0.97	neutral	0.25	neutral	1	deleterious	0.88	deleterious	-2.19	low_impact	0.18	medium_impact	1.64	medium_impact	0.72	0.85	55.1	12.5	0.35	N	0.97	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10726	10726	G	A	MI.16231	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	257	86	G	D	gGc/gAc	2.37	0.99	0	probably_damaging	0.98	neutral	0.31	neutral	1.48	deleterious	-3.42	deleterious	-6.79	high_impact	4.34	0.7	neutral	0.19	damaging	3.93	23.50	deleterious	0.28	0.45	0.89	disease	0.96	disease	0.7	disease	0.84	disease	7	0.98	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-2.35	low_impact	0.02	medium_impact	2.5	high_impact	0.37	0.8	55.1	12.5	0.56	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10726	10726	G	T	MI.16232	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	257	86	G	V	gGc/gTc	2.37	0.99	0	probably_damaging	0.99	neutral	0.52	neutral	1.44	deleterious	-4.7	deleterious	-8.68	high_impact	4.7	0.67	neutral	0.23	damaging	3.90	23.50	deleterious	0.27	0.45	0.91	disease	0.95	disease	0.66	disease	0.83	disease	6	0.99	deleterious	0.27	neutral	2	deleterious	0.91	deleterious	-2.63	low_impact	0.23	medium_impact	2.8	high_impact	0.44	0.8	55.1	12.5	0.65	P	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10726	10726	G	C	MI.16233	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	257	86	G	A	gGc/gCc	2.37	0.99	0	probably_damaging	0.97	neutral	0.53	neutral	1.48	deleterious	-3.28	deleterious	-5.78	high_impact	3.72	0.77	neutral	0.48	neutral	3.16	22.60	deleterious	0.48	0.55	0.79	disease	0.87	disease	0.46	neutral	0.61	disease	2	0.96	neutral	0.28	neutral	2	deleterious	0.87	deleterious	-2.19	low_impact	0.24	medium_impact	1.98	medium_impact	0.81	0.85	55.1	12.5	0.46	N	0.98	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10728	10728	C	G	MI.16234	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	259	87	L	V	Cta/Gta	-20	0	0.01	probably_damaging	0.98	neutral	0.52	neutral	1.98	neutral	-0.69	neutral	-1.18	neutral_impact	0.41	0.83	neutral	0.79	neutral	2.15	17.19	deleterious	0.71	0.75	0.17	neutral	0.39	neutral	0.5	neutral	0.45	neutral	1	0.97	neutral	0.27	neutral	-2	neutral	0.64	deleterious	-2.35	low_impact	0.23	medium_impact	-0.79	medium_impact	0.74	0.85	32.65	17.69	0.29	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10728	10728	C	A	MI.16235	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	259	87	L	M	Cta/Ata	-20	0	0.01	probably_damaging	1	neutral	0.27	neutral	1.96	neutral	-1.74	neutral	-0.69	low_impact	1.45	0.81	neutral	0.85	neutral	3.44	23.00	deleterious	0.49	0.55	0.32	neutral	0.32	neutral	0.32	neutral	0.47	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.66	deleterious	-3.55	low_impact	-0.03	medium_impact	0.08	medium_impact	0.71	0.85	32.65	17.69	0.4	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10729	10729	T	C	MI.16236	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	260	87	L	P	cTa/cCa	-0.4	0	0	probably_damaging	1	neutral	0.19	neutral	1.97	neutral	-1.24	deleterious	-3.74	low_impact	1.64	0.64	neutral	0.32	neutral	3.99	23.60	deleterious	0.43	0.55	0.3	neutral	0.88	disease	0.52	disease	0.79	disease	6	1	deleterious	0.1	neutral	-2	neutral	0.77	deleterious	-3.55	low_impact	-0.14	medium_impact	0.24	medium_impact	0.52	0.8	32.65	17.69	0.34	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10729	10729	T	G	MI.16237	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	260	87	L	R	cTa/cGa	-0.4	0	0	benign	0.38	neutral	0.35	neutral	2	neutral	-0.02	deleterious	-2.84	medium_impact	2	0.82	neutral	0.24	damaging	1.42	12.90	neutral	0.45	0.55	0.16	neutral	0.84	disease	0.59	disease	0.81	disease	6	0.59	neutral	0.49	deleterious	-3	neutral	0.38	neutral	-0.61	medium_impact	0.06	medium_impact	0.54	medium_impact	0.68	0.85	32.65	17.69	0.26	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10729	10729	T	A	MI.16238	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	260	87	L	Q	cTa/cAa	-0.4	0	0	probably_damaging	0.98	neutral	0.28	neutral	2.01	neutral	0.29	deleterious	-2.85	low_impact	1.64	0.69	neutral	0.19	damaging	4.14	23.80	deleterious	0.46	0.55	0.14	neutral	0.66	disease	0.51	disease	0.6	disease	2	0.98	deleterious	0.15	neutral	-2	neutral	0.67	deleterious	-2.35	low_impact	-0.02	medium_impact	0.24	medium_impact	0.74	0.85	32.65	17.69	0.29	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10731	10731	G	A	MI.16239	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	262	88	D	N	Gac/Aac	-7.55	0	0	benign	0.29	neutral	0.52	neutral	1.66	deleterious	-3.48	deleterious	-4.8	high_impact	3.88	0.73	neutral	0.5	neutral	2.41	18.90	deleterious	0.77	0.8	0.59	disease	0.93	disease	0.71	disease	0.79	disease	6	0.38	neutral	0.62	deleterious	-2	neutral	0.37	neutral	-0.45	medium_impact	0.23	medium_impact	2.11	high_impact	0.77	0.85	53.06	12.24	0.33	N	0.96	disease_causing	0.67	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8451	8451	T	C	MI.1624	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	86	29	L	S	tTa/tCa	0.13	0	0	probably_damaging	0.95	neutral	0.41	neutral	-0.21	deleterious	-9.55	neutral	-0.36	low_impact	1.11	0.96	neutral	0.88	neutral	2.09	16.81	deleterious	0.24813243	0.85	0.09	neutral	0.21	neutral	0.34	neutral	0.11	neutral	8	0.95	neutral	0.23	neutral	-2	neutral	0.68	deleterious	-1.97	low_impact	0.2	medium_impact	-0.15	medium_impact	0.57	0.85	5.88	10.73	0.45	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10731	10731	G	C	MI.16240	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	262	88	D	H	Gac/Cac	-7.55	0	0	probably_damaging	0.95	neutral	0.55	neutral	1.64	deleterious	-4.48	deleterious	-6.72	high_impact	4.13	0.71	neutral	0.21	damaging	3.69	23.30	deleterious	0.45	0.55	0.81	disease	0.95	disease	0.78	disease	0.9	disease	8	0.95	neutral	0.3	neutral	2	deleterious	0.87	deleterious	-1.97	low_impact	0.26	medium_impact	2.32	high_impact	0.54	0.8	53.06	12.24	0.37	N	0.97	disease_causing	0.91	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10731	10731	G	T	MI.16241	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	262	88	D	Y	Gac/Tac	-7.55	0	0	benign	0.29	neutral	0.91	neutral	1.65	deleterious	-4.28	deleterious	-8.64	high_impact	4.68	0.73	neutral	0.25	damaging	2.17	17.34	deleterious	0.27	0.45	0.89	disease	0.98	disease	0.78	disease	0.89	disease	8	0.19	neutral	0.81	deleterious	-2	neutral	0.43	neutral	-0.45	medium_impact	0.77	medium_impact	2.78	high_impact	0.22	0.8	53.06	12.24	0.51	N	0.98	disease_causing	0.96	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10732	10732	A	C	MI.16242	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	263	88	D	A	gAc/gCc	4.21	1	0	possibly_damaging	0.86	neutral	0.67	neutral	1.71	neutral	-2.3	deleterious	-7.65	high_impact	4.13	0.73	neutral	0.49	neutral	3.52	23.10	deleterious	0.38	0.5	0.54	disease	0.94	disease	0.73	disease	0.84	disease	7	0.84	neutral	0.41	neutral	1	deleterious	0.78	deleterious	-1.53	low_impact	0.38	medium_impact	2.32	high_impact	0.51	0.8	53.06	12.24	0.58	P	0.97	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10732	10732	A	G	MI.16243	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	263	88	D	G	gAc/gGc	4.21	1	0	possibly_damaging	0.86	neutral	0.49	neutral	1.65	deleterious	-3.84	deleterious	-6.72	high_impact	4.13	0.7	neutral	0.38	neutral	3.76	23.30	deleterious	0.44	0.55	0.68	disease	0.95	disease	0.74	disease	0.88	disease	8	0.85	neutral	0.32	neutral	1	deleterious	0.73	deleterious	-1.53	low_impact	0.2	medium_impact	2.32	high_impact	0.32	0.8	53.06	12.24	0.63	P	0.94	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10732	10732	A	T	MI.16244	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	263	88	D	V	gAc/gTc	4.21	1	0	probably_damaging	0.93	neutral	0.5	neutral	1.83	neutral	-0.93	deleterious	-8.64	high_impact	3.99	0.68	neutral	0.29	neutral	3.66	23.20	deleterious	0.24	0.45	0.82	disease	0.97	disease	0.76	disease	0.89	disease	8	0.93	neutral	0.29	neutral	2	deleterious	0.85	deleterious	-1.83	low_impact	0.21	medium_impact	2.21	high_impact	0.27	0.8	53.06	12.24	0.6	P	0.98	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10733	10733	C	G	MI.16245	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	264	88	D	E	gaC/gaG	5.6	1	0	possibly_damaging	0.78	neutral	0.49	neutral	1.7	neutral	-2.42	deleterious	-3.84	high_impact	3.58	0.77	neutral	0.37	neutral	3.79	23.40	deleterious	0.68	0.7	0.47	neutral	0.94	disease	0.68	disease	0.82	disease	6	0.76	neutral	0.36	neutral	1	deleterious	0.75	deleterious	-1.31	low_impact	0.2	medium_impact	1.86	medium_impact	0.54	0.8	53.06	12.24	0.61	P	0.93	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10733	10733	C	A	MI.16246	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	264	88	D	E	gaC/gaA	5.6	1	0	possibly_damaging	0.78	neutral	0.49	neutral	1.7	neutral	-2.42	deleterious	-3.84	high_impact	3.58	0.77	neutral	0.37	neutral	3.99	23.60	deleterious	0.68	0.7	0.47	neutral	0.94	disease	0.68	disease	0.82	disease	6	0.76	neutral	0.36	neutral	1	deleterious	0.75	deleterious	-1.31	low_impact	0.2	medium_impact	1.86	medium_impact	0.54	0.8	53.06	12.24	0.59	P	0.93	disease_causing	1	0.20	rs28709356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10734	10734	T	C	MI.16247	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	265	89	Y	H	Tac/Cac	-3.4	0	0	benign	0.01	neutral	0.56	neutral	2	neutral	-0.01	deleterious	-2.88	low_impact	1.11	0.83	neutral	0.91	neutral	-0.78	0.05	neutral	0.68	0.7	0.23	neutral	0.22	neutral	0.31	neutral	0.35	neutral	3	0.42	neutral	0.78	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.27	medium_impact	-0.21	medium_impact	0.30	0.8	37.76	8.67	0.37	N	1.00	polymorphism	0.66	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10734	10734	T	A	MI.16248	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	265	89	Y	N	Tac/Aac	-3.4	0	0	possibly_damaging	0.53	neutral	0.34	neutral	2.04	neutral	0.52	deleterious	-7.18	medium_impact	2.3	0.77	neutral	0.78	neutral	1.65	14.12	neutral	0.48	0.55	0.57	disease	0.73	disease	0.46	neutral	0.61	disease	2	0.65	neutral	0.41	neutral	0	NA	0.52	deleterious	-0.85	medium_impact	0.05	medium_impact	0.79	medium_impact	0.29	0.8	37.76	8.67	0.32	N	0.99	disease_causing	0.85	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10734	10734	T	G	MI.16249	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	265	89	Y	D	Tac/Gac	-3.4	0	0	possibly_damaging	0.72	neutral	0.23	neutral	2.2	neutral	1.79	deleterious	-8.3	medium_impact	3.42	0.78	neutral	0.3	neutral	3.82	23.40	deleterious	0.47	0.55	0.59	disease	0.85	disease	0.67	disease	0.8	disease	6	0.83	neutral	0.26	neutral	0	NA	0.72	deleterious	-1.18	low_impact	-0.08	medium_impact	1.73	medium_impact	0.32	0.8	37.76	8.67	0.35	N	1.00	disease_causing	0.81	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8451	8451	T	G	MI.1625	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	86	29	L	W	tTa/tGa	0.13	0	0	probably_damaging	0.98	neutral	0.18	neutral	-0.21	deleterious	-9.47	deleterious	-3.39	high_impact	3.5	0.98	neutral	0.15	damaging	3.61	23.20	deleterious	0.20000037	0.85	0.8	disease	0.4	neutral	0.49	neutral	0.23	neutral	5	0.99	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-2.36	low_impact	-0.08	medium_impact	1.9	medium_impact	0.63	0.85	5.88	10.73	0.51	N	0.67	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10735	10735	A	T	MI.16250	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	266	89	Y	F	tAc/tTc	0.75	0.09	0	possibly_damaging	0.56	neutral	0.7	neutral	1.95	neutral	-1.41	deleterious	-3.58	medium_impact	2.02	0.8	neutral	0.89	neutral	2.09	16.76	deleterious	0.43	0.55	0.42	neutral	0.68	disease	0.39	neutral	0.5	disease	0	0.47	neutral	0.57	deleterious	0	NA	0.56	deleterious	-0.9	medium_impact	0.41	medium_impact	0.56	medium_impact	0.31	0.8	37.76	8.67	0.26	N	0.92	polymorphism	0.93	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10735	10735	A	G	MI.16251	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	266	89	Y	C	tAc/tGc	0.75	0.09	0	probably_damaging	0.94	neutral	0.18	neutral	1.92	deleterious	-4.04	deleterious	-7.88	high_impact	3.56	0.75	neutral	0.41	neutral	3.60	23.20	deleterious	0.5	0.6	0.84	disease	0.84	disease	0.68	disease	0.81	disease	6	0.96	neutral	0.12	neutral	2	deleterious	0.82	deleterious	-1.9	low_impact	-0.16	medium_impact	1.85	medium_impact	0.09	0.8	37.76	8.67	0.42	N	0.99	disease_causing	0.61	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10735	10735	A	C	MI.16252	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	266	89	Y	S	tAc/tCc	0.75	0.09	0	possibly_damaging	0.53	neutral	0.43	neutral	2.02	neutral	0.36	deleterious	-7.47	medium_impact	2.66	0.78	neutral	0.55	neutral	2.19	17.43	deleterious	0.41	0.5	0.52	disease	0.73	disease	0.56	disease	0.68	disease	4	0.57	neutral	0.45	neutral	0	NA	0.58	deleterious	-0.85	medium_impact	0.14	medium_impact	1.09	medium_impact	0.30	0.8	37.76	8.67	0.34	N	0.98	polymorphism	0.5	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10737	10737	G	C	MI.16253	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	268	90	V	L	Gta/Cta	-5.01	0	0	benign	0.17	neutral	1	neutral	1.74	neutral	-0.57	deleterious	-2.69	low_impact	1.02	0.69	neutral	0.56	neutral	-0.89	0.03	neutral	0.57	0.65	0.13	neutral	0.2	neutral	0.21	neutral	0.38	neutral	2	0.17	neutral	0.92	deleterious	-6	neutral	0.14	neutral	-0.17	medium_impact	1.88	high_impact	-0.28	medium_impact	0.73	0.85	22.45	16.15	0.28	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10737	10737	G	T	MI.16254	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	268	90	V	L	Gta/Tta	-5.01	0	0	benign	0.17	neutral	1	neutral	1.74	neutral	-0.57	deleterious	-2.69	low_impact	1.02	0.69	neutral	0.56	neutral	-0.79	0.05	neutral	0.57	0.65	0.13	neutral	0.2	neutral	0.21	neutral	0.38	neutral	2	0.17	neutral	0.92	deleterious	-6	neutral	0.14	neutral	-0.17	medium_impact	1.88	high_impact	-0.28	medium_impact	0.73	0.85	22.45	16.15	0.28	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10737	10737	G	A	MI.16255	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	268	90	V	M	Gta/Ata	-5.01	0	0	possibly_damaging	0.85	neutral	0.23	neutral	1.6	neutral	-2.97	deleterious	-2.84	medium_impact	2.12	0.71	neutral	0.51	neutral	2.59	20.10	deleterious	0.47	0.55	0.35	neutral	0.4	neutral	0.28	neutral	0.47	neutral	1	0.9	neutral	0.19	neutral	0	NA	0.60	deleterious	-1.49	low_impact	-0.08	medium_impact	0.64	medium_impact	0.64	0.8	22.45	16.15	0.43	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10738	10738	T	C	MI.16256	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	269	90	V	A	gTa/gCa	0.06	0.01	0	possibly_damaging	0.52	neutral	0.45	neutral	1.61	deleterious	-3.08	deleterious	-3.97	high_impact	3.89	0.72	neutral	0.57	neutral	1.95	15.87	deleterious	0.48	0.55	0.5	disease	0.51	disease	0.61	disease	0.71	disease	4	0.55	neutral	0.47	neutral	1	deleterious	0.44	deleterious	-0.84	medium_impact	0.16	medium_impact	2.12	high_impact	0.42	0.8	22.45	16.15	0.45	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10738	10738	T	A	MI.16257	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	269	90	V	E	gTa/gAa	0.06	0.01	0	probably_damaging	0.92	neutral	0.22	neutral	1.56	deleterious	-4.96	deleterious	-5.96	high_impact	3.89	0.68	neutral	0.37	neutral	4.71	24.60	deleterious	0.11	0.4	0.77	disease	0.85	disease	0.73	disease	0.81	disease	6	0.94	neutral	0.15	neutral	2	deleterious	0.83	deleterious	-1.78	low_impact	-0.1	medium_impact	2.12	high_impact	0.44	0.8	22.45	16.15	0.36	N	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10738	10738	T	G	MI.16258	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	269	90	V	G	gTa/gGa	0.06	0.01	0	probably_damaging	0.92	neutral	0.3	neutral	1.55	deleterious	-5	deleterious	-6.96	high_impact	3.89	0.68	neutral	0.49	neutral	3.85	23.40	deleterious	0.17	0.45	0.76	disease	0.73	disease	0.64	disease	0.74	disease	5	0.93	neutral	0.19	neutral	2	deleterious	0.76	deleterious	-1.78	low_impact	0.01	medium_impact	2.12	high_impact	0.40	0.8	22.45	16.15	0.38	N	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10740	10740	C	G	MI.16259	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	271	91	H	D	Cat/Gat	-4.78	0	0	benign	0.12	neutral	0.22	neutral	2.12	neutral	2.05	neutral	-1.7	neutral_impact	0.55	0.83	neutral	0.46	neutral	2.26	17.90	deleterious	0.5	0.6	0.18	neutral	0.67	disease	0.53	disease	0.64	disease	3	0.75	neutral	0.55	deleterious	-6	neutral	0.22	neutral	-0.01	medium_impact	-0.1	medium_impact	-0.68	medium_impact	0.63	0.8	22.45	17.54	0.31	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8452	8452	A	C	MI.1626	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	87	29	L	F	ttA/ttC	-0.8	0	0	probably_damaging	0.95	neutral	0.71	neutral	-0.14	deleterious	-5.58	neutral	-1.96	high_impact	3.5	0.98	neutral	0.23	damaging	2.10	16.85	deleterious	0.56070775	0.85	0.5	neutral	0.27	neutral	0.4	neutral	0.14	neutral	7	0.94	neutral	0.38	neutral	2	deleterious	0.73	deleterious	-1.97	low_impact	0.51	medium_impact	1.9	medium_impact	0.44	0.85	5.88	10.73	0.36	N	0.45	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10740	10740	C	T	MI.16260	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	271	91	H	Y	Cat/Tat	-4.78	0	0	benign	0.37	neutral	1	neutral	1.98	neutral	-1.02	neutral	-1.95	low_impact	1.04	0.83	neutral	0.54	neutral	3.50	23.10	deleterious	0.85	0.9	0.36	neutral	0.58	disease	0.57	disease	0.71	disease	4	0.37	neutral	0.82	deleterious	-6	neutral	0.36	neutral	-0.59	medium_impact	1.88	high_impact	-0.27	medium_impact	0.48	0.8	22.45	17.54	0.21	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10740	10740	C	A	MI.16261	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	271	91	H	N	Cat/Aat	-4.78	0	0	benign	0	neutral	0.35	neutral	2.07	neutral	1.51	neutral	-1.29	neutral_impact	-0.94	0.86	neutral	0.85	neutral	2.10	16.85	deleterious	0.84	0.85	0.18	neutral	0.56	disease	0.37	neutral	0.44	neutral	1	0.65	neutral	0.68	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.06	medium_impact	-1.93	low_impact	0.67	0.85	22.45	17.54	0.32	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10741	10741	A	C	MI.16262	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	272	91	H	P	cAt/cCt	0.52	0.09	0	possibly_damaging	0.5	neutral	0.2	neutral	1.98	neutral	-0.9	deleterious	-2.5	low_impact	1.25	0.75	neutral	0.4	neutral	2.93	22.00	deleterious	0.32	0.5	0.32	neutral	0.87	disease	0.68	disease	0.82	disease	6	0.78	neutral	0.35	neutral	-3	neutral	0.42	neutral	-0.8	medium_impact	-0.12	medium_impact	-0.09	medium_impact	0.54	0.8	22.45	17.54	0.39	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10741	10741	A	G	MI.16263	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	272	91	H	R	cAt/cGt	0.52	0.09	0	benign	0.12	neutral	0.37	neutral	2.06	neutral	1.44	neutral	-0.66	neutral_impact	0.78	0.77	neutral	0.63	neutral	1.20	11.74	neutral	0.88	0.9	0.16	neutral	0.63	disease	0.47	neutral	0.51	disease	0	0.57	neutral	0.63	deleterious	-6	neutral	0.21	neutral	-0.01	medium_impact	0.08	medium_impact	-0.48	medium_impact	0.39	0.8	22.45	17.54	0.35	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10741	10741	A	T	MI.16264	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	272	91	H	L	cAt/cTt	0.52	0.09	0	benign	0.18	neutral	0.68	neutral	2	neutral	-0.17	deleterious	-3.65	neutral_impact	0.24	0.8	neutral	0.54	neutral	2.04	16.47	deleterious	0.52	0.6	0.21	neutral	0.69	disease	0.55	disease	0.71	disease	4	0.2	neutral	0.75	deleterious	-6	neutral	0.25	neutral	-0.2	medium_impact	0.39	medium_impact	-0.94	medium_impact	0.48	0.8	22.45	17.54	0.25	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10742	10742	T	G	MI.16265	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	273	91	H	Q	caT/caG	5.6	0.85	0	benign	0.01	neutral	0.39	neutral	2.21	neutral	2.8	neutral	2.31	neutral_impact	-2.24	0.87	neutral	0.98	neutral	-0.98	0.02	neutral	0.9	0.95	0.18	neutral	0.11	neutral	0.31	neutral	0.23	neutral	5	0.6	neutral	0.69	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	0.1	medium_impact	-3.02	low_impact	0.59	0.8	22.45	17.54	0.46	N	0.06	polymorphism	0.62	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10742	10742	T	A	MI.16266	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	273	91	H	Q	caT/caA	5.6	0.85	0	benign	0.01	neutral	0.39	neutral	2.21	neutral	2.8	neutral	2.31	neutral_impact	-2.24	0.87	neutral	0.98	neutral	-0.81	0.04	neutral	0.9	0.95	0.18	neutral	0.11	neutral	0.31	neutral	0.23	neutral	5	0.6	neutral	0.69	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	0.1	medium_impact	-3.02	low_impact	0.59	0.8	22.45	17.54	0.46	N	0.06	polymorphism	0.62	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10743	10743	A	T	MI.16267	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	274	92	N	Y	Aac/Tac	-0.17	0.57	0	probably_damaging	1	neutral	1	neutral	1.84	deleterious	-3.41	deleterious	-7.58	high_impact	4.06	0.74	neutral	0.08	damaging	3.69	23.30	deleterious	0.62	0.65	0.8	disease	0.87	disease	0.68	disease	0.78	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.86	deleterious	-3.55	low_impact	1.88	high_impact	2.27	high_impact	0.27	0.8	53.06	11.8	0.33	N	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10743	10743	A	G	MI.16268	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	274	92	N	D	Aac/Gac	-0.17	0.57	0	probably_damaging	1	neutral	0.27	neutral	1.9	neutral	0.01	deleterious	-4.72	medium_impact	3.09	0.72	neutral	0.09	damaging	3.88	23.50	deleterious	0.92	0.95	0.45	neutral	0.76	disease	0.64	disease	0.68	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	-0.03	medium_impact	1.45	medium_impact	0.58	0.8	53.06	11.8	0.33	N	0.96	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10743	10743	A	C	MI.16269	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	274	92	N	H	Aac/Cac	-0.17	0.57	0	probably_damaging	1	neutral	0.53	neutral	1.86	neutral	-2.57	deleterious	-4.74	high_impact	4.06	0.75	neutral	0.08	damaging	3.14	22.60	deleterious	0.83	0.85	0.73	disease	0.81	disease	0.68	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	0.24	medium_impact	2.27	high_impact	0.32	0.8	53.06	11.8	0.3	N	0.99	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8452	8452	A	T	MI.1627	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	87	29	L	F	ttA/ttT	-0.8	0	0	probably_damaging	0.95	neutral	0.71	neutral	-0.14	deleterious	-5.58	neutral	-1.96	high_impact	3.5	0.98	neutral	0.23	damaging	2.23	17.72	deleterious	0.56070775	0.85	0.5	neutral	0.27	neutral	0.4	neutral	0.14	neutral	7	0.94	neutral	0.38	neutral	2	deleterious	0.73	deleterious	-1.97	low_impact	0.51	medium_impact	1.9	medium_impact	0.44	0.85	5.88	10.73	0.36	N	0.45	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10744	10744	A	G	MI.16270	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	275	92	N	S	aAc/aGc	4.67	0.98	0	probably_damaging	1	neutral	0.78	neutral	2.04	neutral	0.02	deleterious	-4.6	low_impact	1.14	0.78	neutral	0.83	neutral	2.13	17.04	deleterious	0.89	0.9	0.14	neutral	0.5	neutral	0.36	neutral	0.4	neutral	2	1	deleterious	0.39	neutral	-2	neutral	0.72	deleterious	-3.55	low_impact	0.52	medium_impact	-0.18	medium_impact	0.19	0.8	53.06	11.8	0.41	N	0.89	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10744	10744	A	C	MI.16271	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	275	92	N	T	aAc/aCc	4.67	0.98	0	probably_damaging	1	neutral	0.47	neutral	1.89	neutral	-1.53	deleterious	-5.6	medium_impact	2.35	0.76	neutral	0.22	damaging	3.45	23.00	deleterious	0.81	0.85	0.5	neutral	0.73	disease	0.42	neutral	0.56	disease	1	1	deleterious	0.24	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	0.18	medium_impact	0.83	medium_impact	0.31	0.8	53.06	11.8	0.48	N	0.95	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10744	10744	A	T	MI.16272	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	275	92	N	I	aAc/aTc	4.67	0.98	0	probably_damaging	1	neutral	0.43	neutral	1.87	deleterious	-3.04	deleterious	-8.52	medium_impact	2.75	0.73	neutral	0.09	damaging	4.06	23.70	deleterious	0.64	0.7	0.75	disease	0.85	disease	0.63	disease	0.73	disease	5	1	deleterious	0.22	neutral	1	deleterious	0.84	deleterious	-3.55	low_impact	0.14	medium_impact	1.17	medium_impact	0.20	0.8	53.06	11.8	0.48	N	0.98	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10745	10745	C	G	MI.16273	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	276	92	N	K	aaC/aaG	2.37	0.94	0	probably_damaging	1	neutral	0.46	neutral	1.96	neutral	-0.67	deleterious	-5.66	high_impact	3.51	0.67	neutral	0.08	damaging	4.13	23.80	deleterious	0.94	0.95	0.51	disease	0.86	disease	0.66	disease	0.75	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	0.17	medium_impact	1.8	medium_impact	0.48	0.8	53.06	11.8	0.38	N	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10745	10745	C	A	MI.16274	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	276	92	N	K	aaC/aaA	2.37	0.94	0	probably_damaging	1	neutral	0.46	neutral	1.96	neutral	-0.67	deleterious	-5.66	high_impact	3.51	0.67	neutral	0.08	damaging	4.60	24.40	deleterious	0.94	0.95	0.51	disease	0.86	disease	0.66	disease	0.75	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	0.17	medium_impact	1.8	medium_impact	0.48	0.8	53.06	11.8	0.38	N	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10746	10746	C	G	MI.16275	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	277	93	L	V	Cta/Gta	-0.4	0	0	probably_damaging	1	neutral	0.35	neutral	1.53	neutral	-2.42	deleterious	-2.97	medium_impact	3.24	0.75	neutral	0.43	neutral	3.49	23.10	deleterious	0.59	0.65	0.5	neutral	0.52	disease	0.7	disease	0.72	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	0.06	medium_impact	1.58	medium_impact	0.59	0.8	55.1	12.14	0.37	N	0.75	disease_causing	0.92	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10746	10746	C	A	MI.16276	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	277	93	L	M	Cta/Ata	-0.4	0	0	probably_damaging	1	neutral	0.17	neutral	1.51	neutral	-2.65	neutral	-1.98	medium_impact	2.46	0.76	neutral	0.62	neutral	4.01	23.60	deleterious	0.35	0.5	0.31	neutral	0.44	neutral	0.43	neutral	0.42	neutral	2	1	deleterious	0.09	neutral	1	deleterious	0.73	deleterious	-3.55	low_impact	-0.17	medium_impact	0.92	medium_impact	0.75	0.85	55.1	12.14	0.44	N	0.77	disease_causing	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10747	10747	T	C	MI.16277	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	278	93	L	P	cTa/cCa	-0.17	0	0	probably_damaging	1	neutral	0.15	neutral	1.41	deleterious	-5.73	deleterious	-6.94	medium_impact	3.44	0.57	damaging	0.28	damaging	2.51	19.53	deleterious	0.27	0.45	0.9	disease	0.83	disease	0.79	disease	0.87	disease	7	1	deleterious	0.08	neutral	1	deleterious	0.91	deleterious	-3.55	low_impact	-0.21	medium_impact	1.75	medium_impact	0.50	0.8	55.1	12.14	0.36	N	1.00	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10747	10747	T	A	MI.16278	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	278	93	L	Q	cTa/cAa	-0.17	0	0	probably_damaging	1	neutral	0.21	neutral	1.42	deleterious	-5.32	deleterious	-5.95	high_impact	4.34	0.69	neutral	0.3	neutral	4.46	24.20	deleterious	0.24	0.45	0.86	disease	0.82	disease	0.7	disease	0.78	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.11	medium_impact	2.5	high_impact	0.64	0.8	55.1	12.14	0.39	N	0.99	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10747	10747	T	G	MI.16279	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	278	93	L	R	cTa/cGa	-0.17	0	0	probably_damaging	1	neutral	0.26	neutral	1.43	deleterious	-4.39	deleterious	-5.95	high_impact	4.34	0.57	damaging	0.23	damaging	4.52	24.30	deleterious	0.21	0.45	0.87	disease	0.85	disease	0.79	disease	0.87	disease	7	1	deleterious	0.13	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	-0.04	medium_impact	2.5	high_impact	0.51	0.8	55.1	12.14	0.48	N	0.99	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8453	8453	A	G	MI.1628	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	88	30	N	D	Aac/Gac	-2.42	0	0	possibly_damaging	0.87	neutral	0.23	neutral	1.11	neutral	-2.83	neutral	-2.31	medium_impact	2.75	0.97	neutral	0.72	neutral	2.35	18.50	deleterious	0.84509432	0.90	0.32	neutral	0.39	neutral	0.45	neutral	0.18	neutral	6	0.91	neutral	0.18	neutral	0	NA	0.68	deleterious	-1.54	low_impact	-0.01	medium_impact	1.26	medium_impact	0.74	0.85	NA	NA	0.54	N	0.55	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10749	10749	A	T	MI.16280	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	280	94	N	Y	Aac/Tac	-6.86	0	0	probably_damaging	0.96	neutral	1	neutral	1.65	deleterious	-4.87	deleterious	-7.52	high_impact	4.38	0.67	neutral	0.28	neutral	4.01	23.60	deleterious	0.61	0.65	0.79	disease	0.86	disease	0.71	disease	0.79	disease	6	0.96	neutral	0.52	deleterious	2	deleterious	0.84	deleterious	-2.07	low_impact	1.88	high_impact	2.53	high_impact	0.46	0.8	50	10.05	0.36	N	0.99	disease_causing	0.84	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10749	10749	A	G	MI.16281	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	280	94	N	D	Aac/Gac	-6.86	0	0	possibly_damaging	0.64	neutral	0.21	neutral	1.71	neutral	-2.21	deleterious	-4.63	high_impact	3.69	0.7	neutral	0.37	neutral	3.83	23.40	deleterious	0.84	0.85	0.49	neutral	0.75	disease	0.69	disease	0.7	disease	4	0.81	neutral	0.29	neutral	1	deleterious	0.63	deleterious	-1.03	low_impact	-0.11	medium_impact	1.96	medium_impact	0.66	0.8	50	10.05	0.38	N	0.96	polymorphism	0.62	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10749	10749	A	C	MI.16282	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	280	94	N	H	Aac/Cac	-6.86	0	0	probably_damaging	0.96	neutral	0.54	neutral	1.66	deleterious	-4.01	deleterious	-4.71	high_impact	4.38	0.75	neutral	0.28	damaging	3.38	22.90	deleterious	0.76	0.8	0.71	disease	0.79	disease	0.71	disease	0.74	disease	5	0.96	neutral	0.29	neutral	2	deleterious	0.82	deleterious	-2.07	low_impact	0.25	medium_impact	2.53	high_impact	0.48	0.8	50	10.05	0.38	N	0.99	disease_causing	0.56	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10750	10750	A	C	MI.16283	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	281	94	N	T	aAc/aCc	6.75	1	0.01	possibly_damaging	0.64	neutral	0.4	neutral	1.76	deleterious	-3.01	deleterious	-5.45	medium_impact	2.94	0.73	neutral	0.57	neutral	3.32	22.90	deleterious	0.8	0.85	0.26	neutral	0.8	disease	0.49	neutral	0.63	disease	3	0.67	neutral	0.38	neutral	0	NA	0.55	deleterious	-1.03	low_impact	0.11	medium_impact	1.33	medium_impact	0.46	0.8	50	10.05	0.6	P	0.95	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10750	10750	A	T	MI.16284	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	281	94	N	I	aAc/aTc	6.75	1	0.01	probably_damaging	0.93	neutral	0.44	neutral	1.66	deleterious	-4.41	deleterious	-8.43	high_impact	3.84	0.74	neutral	0.45	neutral	4.10	23.70	deleterious	0.53	0.6	0.71	disease	0.85	disease	0.66	disease	0.75	disease	5	0.93	neutral	0.26	neutral	2	deleterious	0.80	deleterious	-1.83	low_impact	0.15	medium_impact	2.08	high_impact	0.35	0.8	50	10.05	0.67	P	0.98	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10750	10750	A	G	MI.16285	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	281	94	N	S	aAc/aGc	6.75	1	0.01	benign	0.08	neutral	0.51	neutral	1.82	neutral	-1.34	deleterious	-4.29	low_impact	1.41	0.82	neutral	0.54	neutral	0.32	5.85	deleterious	0.87	0.9	0.25	neutral	0.61	disease	0.45	neutral	0.43	neutral	1	0.42	neutral	0.72	deleterious	-6	neutral	0.24	neutral	0.17	medium_impact	0.22	medium_impact	0.04	medium_impact	0.28	0.8	50	10.05	0.48	N	0.89	disease_causing	1	0.09	rs372297272	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10751	10751	C	A	MI.16286	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	282	94	N	K	aaC/aaA	5.36	1	0	possibly_damaging	0.75	neutral	0.3	neutral	1.75	neutral	-2.52	deleterious	-5.54	medium_impact	2.76	0.74	neutral	0.42	neutral	4.48	24.20	deleterious	0.88	0.9	0.48	neutral	0.83	disease	0.65	disease	0.68	disease	4	0.81	neutral	0.28	neutral	0	NA	0.63	deleterious	-1.24	low_impact	0.01	medium_impact	1.18	medium_impact	0.51	0.8	50	10.05	0.58	P	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10751	10751	C	G	MI.16287	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	282	94	N	K	aaC/aaG	5.36	1	0	possibly_damaging	0.75	neutral	0.3	neutral	1.75	neutral	-2.52	deleterious	-5.54	medium_impact	2.76	0.74	neutral	0.42	neutral	4.01	23.60	deleterious	0.88	0.9	0.48	neutral	0.83	disease	0.65	disease	0.68	disease	4	0.81	neutral	0.28	neutral	0	NA	0.63	deleterious	-1.24	low_impact	0.01	medium_impact	1.18	medium_impact	0.51	0.8	50	10.05	0.57	P	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10752	10752	C	G	MI.16288	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	283	95	L	V	Cta/Gta	-0.86	0	0	benign	0.29	neutral	0.17	neutral	1.65	neutral	-1.58	deleterious	-2.59	medium_impact	2.81	0.82	neutral	0.42	neutral	1.90	15.57	deleterious	0.75	0.8	0.23	neutral	0.38	neutral	0.35	neutral	0.41	neutral	2	0.8	neutral	0.44	neutral	-3	neutral	0.21	neutral	-0.45	medium_impact	-0.17	medium_impact	1.22	medium_impact	0.49	0.8	56.12	12.6	0.42	N	0.75	disease_causing	0.94	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10752	10752	C	A	MI.16289	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	283	95	L	M	Cta/Ata	-0.86	0	0	possibly_damaging	0.68	neutral	0.1	neutral	1.57	deleterious	-3.01	neutral	-1.83	medium_impact	2.37	0.83	neutral	0.57	neutral	3.94	23.50	deleterious	0.53	0.6	0.55	disease	0.37	neutral	0.32	neutral	0.54	disease	1	0.91	neutral	0.21	neutral	0	NA	0.53	deleterious	-1.1	low_impact	-0.32	medium_impact	0.85	medium_impact	0.55	0.8	56.12	12.6	0.44	N	0.77	disease_causing	0.93	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8453	8453	A	T	MI.1629	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	88	30	N	Y	Aac/Tac	-2.42	0	0	probably_damaging	0.98	neutral	1	neutral	1.03	deleterious	-5.17	deleterious	-4.24	medium_impact	3.1	0.99	neutral	0.64	neutral	3.58	23.20	deleterious	0.46398601	0.85	0.66	disease	0.5	disease	0.58	disease	0.58	disease	2	0.98	neutral	0.51	deleterious	1	deleterious	0.78	deleterious	-2.36	low_impact	1.98	high_impact	1.56	medium_impact	0.59	0.85	NA	NA	0.32	N	0.68	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10753	10753	T	G	MI.16290	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	284	95	L	R	cTa/cGa	0.29	0.02	0	probably_damaging	0.98	neutral	0.1	neutral	1.57	deleterious	-5.19	deleterious	-5.73	high_impact	3.71	0.59	damaging	0.21	damaging	4.48	24.20	deleterious	0.49	0.55	0.86	disease	0.77	disease	0.68	disease	0.77	disease	5	0.99	deleterious	0.06	neutral	2	deleterious	0.86	deleterious	-2.35	low_impact	-0.32	medium_impact	1.97	medium_impact	0.41	0.8	56.12	12.6	0.34	N	0.99	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10753	10753	T	C	MI.16291	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	284	95	L	P	cTa/cCa	0.29	0.02	0	probably_damaging	0.99	deleterious	0.04	neutral	1.54	deleterious	-5.79	deleterious	-6.6	medium_impact	3.5	0.56	damaging	0.23	damaging	4.19	23.80	deleterious	0.63	0.7	0.88	disease	0.76	disease	0.73	disease	0.79	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.87	deleterious	-2.63	low_impact	-0.56	medium_impact	1.8	medium_impact	0.44	0.8	56.12	12.6	0.3	N	1.00	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10753	10753	T	A	MI.16292	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	284	95	L	Q	cTa/cAa	0.29	0.02	0	probably_damaging	0.98	neutral	0.08	neutral	1.57	deleterious	-5.23	deleterious	-5.68	high_impact	4.4	0.68	neutral	0.3	neutral	4.37	24.10	deleterious	0.51	0.6	0.86	disease	0.75	disease	0.63	disease	0.76	disease	5	0.99	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-2.35	low_impact	-0.38	medium_impact	2.55	high_impact	0.41	0.8	56.12	12.6	0.42	N	0.99	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10755	10755	C	T	MI.16293	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	286	96	L	F	Ctc/Ttc	-12.39	0	0	possibly_damaging	0.5	neutral	0.13	neutral	1.36	deleterious	-4.29	deleterious	-3.53	high_impact	3.6	0.65	neutral	0.08	damaging	3.85	23.40	deleterious	0.6	0.65	0.61	disease	0.45	neutral	0.62	disease	0.57	disease	1	0.86	neutral	0.32	neutral	1	deleterious	0.45	deleterious	-0.8	medium_impact	-0.25	medium_impact	1.88	medium_impact	0.51	0.8	54.08	12.35	0.29	N	0.97	polymorphism	0.82	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10755	10755	C	G	MI.16294	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	286	96	L	V	Ctc/Gtc	-12.39	0	0	probably_damaging	0.92	neutral	0.1	neutral	1.42	deleterious	-3.31	deleterious	-2.89	medium_impact	3.43	0.58	damaging	0.05	damaging	3.67	23.20	deleterious	0.59	0.65	0.52	disease	0.34	neutral	0.66	disease	0.44	neutral	1	0.97	neutral	0.09	neutral	1	deleterious	0.74	deleterious	-1.78	low_impact	-0.32	medium_impact	1.74	medium_impact	0.49	0.8	54.08	12.35	0.33	N	0.75	polymorphism	0.96	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10755	10755	C	A	MI.16295	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	286	96	L	I	Ctc/Atc	-12.39	0	0	possibly_damaging	0.9	neutral	0.12	neutral	1.44	deleterious	-3.02	neutral	-1.9	medium_impact	3.43	0.6	neutral	0.06	damaging	4.36	24.10	deleterious	0.48	0.55	0.45	neutral	0.37	neutral	0.65	disease	0.44	neutral	1	0.96	neutral	0.11	neutral	0	NA	0.72	deleterious	-1.68	low_impact	-0.27	medium_impact	1.74	medium_impact	0.76	0.85	54.08	12.35	0.37	N	0.80	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10756	10756	T	C	MI.16296	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	287	96	L	P	cTc/cCc	0.29	0.02	0	probably_damaging	1	deleterious	0.02	neutral	1.32	deleterious	-6.88	deleterious	-6.82	high_impact	3.86	0.41	damaging	0.05	damaging	4.23	23.90	deleterious	0.38	0.5	0.91	disease	0.69	disease	0.74	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.55	low_impact	-0.73	medium_impact	2.1	high_impact	0.45	0.8	54.08	12.35	0.49	P	1.00	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10756	10756	T	A	MI.16297	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	287	96	L	H	cTc/cAc	0.29	0.02	0	probably_damaging	1	neutral	0.06	neutral	1.33	deleterious	-7.06	deleterious	-6.69	medium_impact	3.16	0.59	damaging	0.05	damaging	4.57	24.40	deleterious	0.31	0.5	0.93	disease	0.68	disease	0.64	disease	0.78	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.86	deleterious	-3.55	low_impact	-0.45	medium_impact	1.51	medium_impact	0.64	0.8	54.08	12.35	0.27	N	1.00	disease_causing	0.84	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10756	10756	T	G	MI.16298	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	287	96	L	R	cTc/cGc	0.29	0.02	0	probably_damaging	1	neutral	0.06	neutral	1.33	deleterious	-6.15	deleterious	-5.83	high_impact	4.41	0.47	damaging	0.04	damaging	4.46	24.20	deleterious	0.32	0.5	0.89	disease	0.72	disease	0.69	disease	0.76	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.45	medium_impact	2.56	high_impact	0.57	0.8	54.08	12.35	0.43	N	0.99	disease_causing	0.9	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10758	10758	C	G	MI.16299	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	289	97	Q	E	Caa/Gaa	-1.32	0	0	probably_damaging	1	neutral	0.27	neutral	1.97	neutral	-0.24	deleterious	-2.65	medium_impact	3.08	0.67	neutral	0.32	neutral	3.13	22.60	deleterious	0.76	0.8	0.2	neutral	0.49	neutral	0.46	neutral	0.45	neutral	1	1	deleterious	0.14	neutral	1	deleterious	0.73	deleterious	-3.55	low_impact	-0.03	medium_impact	1.44	medium_impact	0.81	0.85	58.16	11.18	0.43	N	0.91	disease_causing	0.93	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8602	8602	T	G	MI.163	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	76	26	F	V	Ttt/Gtt	-2.65	0	0.01	benign	0.09	neutral	0.07	neutral	4.36	neutral	-0.26	deleterious	-3.14	low_impact	1.38	0.87	neutral	0.59	neutral	0.75	9.18	deleterious	0.32	0.65	0.51	disease	0.56	disease	0.38	neutral	0.5	neutral	0	0.92	neutral	0.49	deleterious	-6	neutral	0.22	neutral	0.2	medium_impact	-0.34	medium_impact	0.09	medium_impact	0.34	0.9	15.49	8.03	0.39	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8453	8453	A	C	MI.1630	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	88	30	N	H	Aac/Cac	-2.42	0	0	probably_damaging	0.98	neutral	0.54	neutral	1.14	neutral	-2.47	deleterious	-2.62	medium_impact	3.1	0.99	neutral	0.52	neutral	2.91	21.90	deleterious	0.66000491	0.85	0.54	disease	0.48	neutral	0.58	disease	0.43	neutral	1	0.97	neutral	0.28	neutral	1	deleterious	0.75	deleterious	-2.36	low_impact	0.33	medium_impact	1.56	medium_impact	0.70	0.85	NA	NA	0.38	N	0.41	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10758	10758	C	A	MI.16300	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	289	97	Q	K	Caa/Aaa	-1.32	0	0	probably_damaging	1	neutral	0.34	neutral	2.05	neutral	0.32	deleterious	-3.17	low_impact	1.6	0.82	neutral	0.84	neutral	2.94	22.00	deleterious	0.8	0.85	0.17	neutral	0.48	neutral	0.41	neutral	0.41	neutral	2	1	deleterious	0.17	neutral	-2	neutral	0.73	deleterious	-3.55	low_impact	0.05	medium_impact	0.2	medium_impact	0.79	0.85	58.16	11.18	0.34	N	0.92	disease_causing	0.96	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10759	10759	A	G	MI.16301	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	290	97	Q	R	cAa/cGa	4.21	1	0	probably_damaging	1	neutral	0.36	neutral	2.08	neutral	0.48	deleterious	-3.28	medium_impact	2.76	0.83	neutral	0.67	neutral	3.50	23.10	deleterious	0.8	0.85	0.3	neutral	0.51	disease	0.54	disease	0.44	neutral	1	1	deleterious	0.18	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	0.07	medium_impact	1.18	medium_impact	0.65	0.8	58.16	11.18	0.55	P	0.72	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10759	10759	A	C	MI.16302	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	290	97	Q	P	cAa/cCa	4.21	1	0	probably_damaging	1	neutral	0.2	neutral	1.81	deleterious	-3.41	deleterious	-5.34	high_impact	4.12	0.66	neutral	0.28	neutral	3.58	23.20	deleterious	0.66	0.7	0.61	disease	0.71	disease	0.53	disease	0.6	disease	2	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.55	low_impact	-0.12	medium_impact	2.32	high_impact	0.53	0.8	58.16	11.18	0.6	P	0.93	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10759	10759	A	T	MI.16303	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	290	97	Q	L	cAa/cTa	4.21	1	0	probably_damaging	1	neutral	0.76	neutral	1.82	neutral	-2.72	deleterious	-6.45	medium_impact	2.73	0.65	neutral	0.33	neutral	4.01	23.60	deleterious	0.47	0.55	0.53	disease	0.65	disease	0.52	disease	0.57	disease	1	1	deleterious	0.38	neutral	1	deleterious	0.77	deleterious	-3.55	low_impact	0.49	medium_impact	1.15	medium_impact	0.51	0.8	58.16	11.18	0.43	N	0.95	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10760	10760	A	C	MI.16304	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	291	97	Q	H	caA/caC	5.6	1	0	probably_damaging	1	neutral	0.53	neutral	1.82	deleterious	-3.11	deleterious	-4.54	high_impact	3.77	0.7	neutral	0.26	damaging	3.08	22.50	deleterious	0.76	0.8	0.55	disease	0.55	disease	0.58	disease	0.64	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.78	deleterious	-3.55	low_impact	0.24	medium_impact	2.02	high_impact	0.70	0.85	58.16	11.18	0.61	P	0.80	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10760	10760	A	T	MI.16305	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	291	97	Q	H	caA/caT	5.6	1	0	probably_damaging	1	neutral	0.53	neutral	1.82	deleterious	-3.11	deleterious	-4.54	high_impact	3.77	0.7	neutral	0.26	damaging	3.12	22.60	deleterious	0.76	0.8	0.55	disease	0.55	disease	0.58	disease	0.64	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.78	deleterious	-3.55	low_impact	0.24	medium_impact	2.02	high_impact	0.70	0.85	58.16	11.18	0.61	P	0.80	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10761	10761	T	A	MI.16306	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	292	98	C	S	Tgc/Agc	5.6	1	0	probably_damaging	1	neutral	0.36	neutral	1.89	deleterious	-3.58	deleterious	-9.79	high_impact	3.83	0.56	damaging	0.03	damaging	3.89	23.50	deleterious	0.31	0.45	NA	NA	0.72	disease	0.67	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.93	deleterious	-3.55	low_impact	0.07	medium_impact	2.07	high_impact	0.30	0.8	NA	NA	0.59	P	0.97	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10761	10761	T	C	MI.16307	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	292	98	C	R	Tgc/Cgc	5.6	1	0	probably_damaging	1	neutral	0.43	neutral	1.97	deleterious	-4.99	deleterious	-11.75	high_impact	4.04	0.63	neutral	0.05	damaging	3.76	23.30	deleterious	0.26	0.45	NA	NA	0.8	disease	0.73	disease	0.74	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.94	deleterious	-3.55	low_impact	0.14	medium_impact	2.25	high_impact	0.17	0.8	NA	NA	0.54	N	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10761	10761	T	G	MI.16308	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	292	98	C	G	Tgc/Ggc	5.6	1	0	probably_damaging	1	neutral	0.31	neutral	2	deleterious	-4.1	deleterious	-11.76	high_impact	4.04	0.57	damaging	0.04	damaging	3.53	23.10	deleterious	0.25	0.45	NA	NA	0.72	disease	0.68	disease	0.69	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.93	deleterious	-3.55	low_impact	0.02	medium_impact	2.25	high_impact	0.24	0.8	NA	NA	0.57	P	1.00	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10762	10762	G	T	MI.16309	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	293	98	C	F	tGc/tTc	7.44	1	0	probably_damaging	1	neutral	0.63	neutral	1.83	deleterious	-5.05	deleterious	-10.71	medium_impact	3.28	0.55	damaging	0.03	damaging	4.07	23.70	deleterious	0.25	0.45	NA	NA	0.82	disease	0.7	disease	0.74	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.94	deleterious	-3.55	low_impact	0.34	medium_impact	1.61	medium_impact	0.30	0.8	NA	NA	0.46	N	0.99	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8454	8454	A	C	MI.1631	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	89	30	N	T	aAc/aCc	-0.33	0	0	probably_damaging	0.92	neutral	0.43	neutral	1.08	deleterious	-3.41	deleterious	-2.84	low_impact	1.48	1	neutral	0.76	neutral	2.16	17.24	deleterious	0.72936886	0.85	0.39	neutral	0.44	neutral	0.28	neutral	0.24	neutral	5	0.92	neutral	0.26	neutral	-2	neutral	0.71	deleterious	-1.76	low_impact	0.22	medium_impact	0.17	medium_impact	0.69	0.85	NA	NA	0.49	N	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10762	10762	G	C	MI.16310	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	293	98	C	S	tGc/tCc	7.44	1	0	probably_damaging	1	neutral	0.36	neutral	1.89	deleterious	-3.58	deleterious	-9.79	high_impact	3.83	0.56	damaging	0.03	damaging	3.32	22.90	deleterious	0.31	0.45	NA	NA	0.72	disease	0.67	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.93	deleterious	-3.55	low_impact	0.07	medium_impact	2.07	high_impact	0.30	0.8	NA	NA	0.58	P	0.97	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10762	10762	G	A	MI.16311	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	293	98	C	Y	tGc/tAc	7.44	1	0	probably_damaging	1	neutral	0.86	neutral	1.83	deleterious	-5.47	deleterious	-10.66	medium_impact	3.48	0.57	damaging	0.03	damaging	3.86	23.50	deleterious	0.25	0.45	NA	NA	0.83	disease	0.73	disease	0.76	disease	5	1	deleterious	0.43	neutral	1	deleterious	0.93	deleterious	-3.55	low_impact	0.65	medium_impact	1.78	medium_impact	0.26	0.8	NA	NA	0.44	N	0.99	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10763	10763	C	A	MI.16312	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	294	98	C	W	tgC/tgA	9.05	1	0	probably_damaging	1	neutral	0.16	neutral	1.84	deleterious	-7.11	deleterious	-10.7	medium_impact	2.81	0.62	neutral	0.03	damaging	4.69	24.60	deleterious	0.22	0.45	NA	NA	0.82	disease	0.76	disease	0.76	disease	5	1	deleterious	0.08	neutral	1	deleterious	0.93	deleterious	-3.55	low_impact	-0.19	medium_impact	1.22	medium_impact	0.26	0.8	NA	NA	0.45	N	0.99	disease_causing	1	0.20	rs28532881	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10763	10763	C	G	MI.16313	MT-ND4L	I	ENSG00000212907	ENSP00000354728	ENST00000361335	NU4LM_HUMAN	P03901	4539	YP_003024034.1	294	98	C	W	tgC/tgG	9.05	1	0	probably_damaging	1	neutral	0.16	neutral	1.84	deleterious	-7.11	deleterious	-10.7	medium_impact	2.81	0.62	neutral	0.03	damaging	4.46	24.20	deleterious	0.22	0.45	NA	NA	0.82	disease	0.76	disease	0.76	disease	5	1	deleterious	0.08	neutral	1	deleterious	0.93	deleterious	-3.55	low_impact	-0.19	medium_impact	1.22	medium_impact	0.26	0.8	NA	NA	0.45	N	0.99	disease_causing	1	0.20	rs28532881	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10760	10760	A	C	MI.16314	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1	1	M	L	Atg/Ctg	5.6	1	0	probably_damaging	0.98	deleterious	0	neutral	0.26	deleterious	-3.7	neutral	-2.2	NA	NA	0.61	neutral	0.11	damaging	3.08	22.50	deleterious	0.04	0.35	NA	NA	0.27	neutral	0.65	disease	0.39	neutral	2	1	deleterious	0.01	neutral	4	deleterious	0.62	deleterious	NA	NA	NA	NA	NA	NA	0.41	0.8	47.06	9.42	0.63	P	0.98	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10760	10760	A	T	MI.16315	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1	1	M	L	Atg/Ttg	5.6	1	0	probably_damaging	0.98	deleterious	0	neutral	0.26	deleterious	-3.7	neutral	-2.2	NA	NA	0.61	neutral	0.11	damaging	3.12	22.60	deleterious	0.04	0.35	NA	NA	0.27	neutral	0.65	disease	0.39	neutral	2	1	deleterious	0.01	neutral	4	deleterious	0.62	deleterious	NA	NA	NA	NA	NA	NA	0.41	0.8	47.06	9.42	0.63	P	0.98	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10761	10761	T	C	MI.16316	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	2	1	M	T	aTg/aCg	5.6	1	0	probably_damaging	1	deleterious	0	neutral	0.08	deleterious	-7.2	deleterious	-4.41	NA	NA	0.67	neutral	0.13	damaging	3.76	23.30	deleterious	0.07	0.35	NA	NA	0.39	neutral	0.67	disease	0.4	neutral	2	1	deleterious	0	neutral	4	deleterious	0.80	deleterious	NA	NA	NA	NA	NA	NA	0.06	0.8	47.06	9.42	0.54	P	0.99	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10761	10761	T	A	MI.16317	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	2	1	M	K	aTg/aAg	5.6	1	0	probably_damaging	1	deleterious	0	neutral	0.08	deleterious	-7.83	deleterious	-4.41	NA	NA	0.64	neutral	0.11	damaging	3.89	23.50	deleterious	0.05	0.35	NA	NA	0.49	neutral	0.69	disease	0.61	disease	2	1	deleterious	0	neutral	4	deleterious	0.82	deleterious	NA	NA	NA	NA	NA	NA	0.15	0.8	47.06	9.42	0.55	P	1.00	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10762	10762	G	T	MI.16318	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	3	1	M	I	atG/atT	7.44	1	0	probably_damaging	0.99	deleterious	0	neutral	0.14	deleterious	-5.15	deleterious	-2.94	NA	NA	0.65	neutral	0.13	damaging	4.07	23.70	deleterious	0.06	0.35	NA	NA	0.34	neutral	0.67	disease	0.39	neutral	2	1	deleterious	0.01	neutral	4	deleterious	0.74	deleterious	NA	NA	NA	NA	NA	NA	0.42	0.8	47.06	9.42	0.56	P	0.95	NA	NA	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10762	10762	G	C	MI.16319	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	3	1	M	I	atG/atC	7.44	1	0	probably_damaging	0.99	deleterious	0	neutral	0.14	deleterious	-5.15	deleterious	-2.94	NA	NA	0.65	neutral	0.13	damaging	3.32	22.90	deleterious	0.06	0.35	NA	NA	0.34	neutral	0.67	disease	0.39	neutral	2	1	deleterious	0.01	neutral	4	deleterious	0.74	deleterious	NA	NA	NA	NA	NA	NA	0.42	0.8	47.06	9.42	0.56	P	0.95	NA	NA	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8454	8454	A	T	MI.1632	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	89	30	N	I	aAc/aTc	-0.33	0	0	probably_damaging	0.98	neutral	0.43	neutral	1.03	deleterious	-6.07	deleterious	-4.71	medium_impact	2.56	0.99	neutral	0.54	neutral	3.72	23.30	deleterious	0.47385093	0.85	0.61	disease	0.51	disease	0.53	disease	0.51	disease	0	0.98	neutral	0.23	neutral	1	deleterious	0.77	deleterious	-2.36	low_impact	0.22	medium_impact	1.1	medium_impact	0.45	0.85	NA	NA	0.48	N	0.68	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10763	10763	C	G	MI.16320	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	4	2	L	V	Cta/Gta	9.05	1	0	possibly_damaging	0.86	deleterious	0.01	neutral	0.86	deleterious	-3.36	neutral	-2.19	medium_impact	3.31	0.67	neutral	0.48	neutral	4.46	24.20	deleterious	0.22	0.45	NA	NA	0.21	neutral	0.38	neutral	0.23	neutral	5	0.99	deleterious	0.08	neutral	4	deleterious	0.77	deleterious	-1.46	low_impact	-0.92	medium_impact	2.15	high_impact	0.46	0.8	46.84	9.11	0.65	P	0.89	polymorphism	1	0.12	rs28532881	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10763	10763	C	A	MI.16321	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	4	2	L	M	Cta/Ata	9.05	1	0	probably_damaging	0.98	neutral	0.11	neutral	0.88	deleterious	-3.11	neutral	-1.46	medium_impact	2.96	0.65	neutral	0.58	neutral	4.69	24.60	deleterious	0.16	0.45	NA	NA	0.15	neutral	0.19	neutral	0.23	neutral	5	0.99	deleterious	0.07	neutral	1	deleterious	0.74	deleterious	-2.31	low_impact	-0.31	medium_impact	1.8	medium_impact	0.41	0.8	46.84	9.11	0.67	P	0.90	polymorphism	1	0.02	rs28532881	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10764	10764	T	G	MI.16322	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	5	2	L	R	cTa/cGa	-0.86	0.02	0	probably_damaging	0.98	deleterious	0	neutral	0.78	deleterious	-5.66	deleterious	-4.4	medium_impact	3.31	0.55	damaging	0.35	neutral	3.94	23.50	deleterious	0.11	0.4	NA	NA	0.53	disease	0.69	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.86	deleterious	-2.31	low_impact	-1.48	low_impact	2.15	high_impact	0.17	0.8	46.84	9.11	0.37	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10764	10764	T	A	MI.16323	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	5	2	L	Q	cTa/cAa	-0.86	0.02	0	probably_damaging	0.99	deleterious	0	neutral	0.77	deleterious	-5.77	deleterious	-4.4	medium_impact	3.31	0.57	damaging	0.4	neutral	3.83	23.40	deleterious	0.18	0.45	NA	NA	0.39	neutral	0.44	neutral	0.19	neutral	6	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-2.59	low_impact	-1.48	low_impact	2.15	high_impact	0.24	0.8	46.84	9.11	0.43	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10764	10764	T	C	MI.16324	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	5	2	L	P	cTa/cCa	-0.86	0.02	0	probably_damaging	0.99	deleterious	0	neutral	0.77	deleterious	-6.28	deleterious	-5.13	medium_impact	3.31	0.53	damaging	0.39	neutral	3.67	23.20	deleterious	0.15	0.45	NA	NA	0.37	neutral	0.68	disease	0.41	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-2.59	low_impact	-1.48	low_impact	2.15	high_impact	0.28	0.8	46.84	9.11	0.38	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10766	10766	A	G	MI.16325	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	7	3	K	E	Aaa/Gaa	8.59	1	0	probably_damaging	1	deleterious	0	neutral	1.22	neutral	-2.3	deleterious	-2.93	medium_impact	3.31	0.56	damaging	0.09	damaging	3.80	23.40	deleterious	0.21	0.45	NA	NA	0.48	neutral	0.5	neutral	0.35	neutral	3	1	deleterious	0	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	2.15	high_impact	0.55	0.8	47.93	9.67	0.58	P	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10766	10766	A	C	MI.16326	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	7	3	K	Q	Aaa/Caa	8.59	1	0	probably_damaging	1	deleterious	0	neutral	1.18	neutral	-2.93	deleterious	-2.93	medium_impact	3.31	0.55	damaging	0.1	damaging	3.25	22.80	deleterious	0.35	0.5	NA	NA	0.37	neutral	0.48	neutral	0.19	neutral	6	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	2.15	high_impact	0.41	0.8	47.93	9.67	0.59	P	0.86	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10767	10767	A	T	MI.16327	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	8	3	K	M	aAa/aTa	8.59	1	0	probably_damaging	1	neutral	0.05	neutral	1.15	deleterious	-3.62	deleterious	-4.39	medium_impact	2.34	0.54	damaging	0.14	damaging	3.60	23.20	deleterious	0.17	0.45	NA	NA	0.4	neutral	0.39	neutral	0.18	neutral	6	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.52	medium_impact	1.19	medium_impact	0.18	0.8	47.93	9.67	0.62	P	0.42	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10767	10767	A	C	MI.16328	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	8	3	K	T	aAa/aCa	8.59	1	0	probably_damaging	1	deleterious	0.04	neutral	1.21	neutral	-2.35	deleterious	-4.39	medium_impact	2.5	0.56	damaging	0.13	damaging	3.39	23.00	deleterious	0.24	0.45	NA	NA	0.34	neutral	0.42	neutral	0.18	neutral	6	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.57	medium_impact	1.35	medium_impact	0.17	0.8	47.93	9.67	0.62	P	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10768	10768	A	T	MI.16329	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	9	3	K	N	aaA/aaT	5.6	1	0	probably_damaging	1	deleterious	0.02	neutral	1.18	neutral	-2.97	deleterious	-3.66	medium_impact	3.31	0.63	neutral	0.09	damaging	3.66	23.20	deleterious	0.5	0.6	NA	NA	0.34	neutral	0.49	neutral	0.19	neutral	6	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.75	medium_impact	2.15	high_impact	0.37	0.8	47.93	9.67	0.64	P	0.72	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8454	8454	A	G	MI.1633	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	89	30	N	S	aAc/aGc	-0.33	0	0	possibly_damaging	0.87	neutral	0.47	neutral	1.14	neutral	-2.4	neutral	-1.77	low_impact	0.96	1	neutral	0.94	neutral	1.57	13.68	neutral	0.91929012	0.95	0.2	neutral	0.23	neutral	0.28	neutral	0.15	neutral	7	0.86	neutral	0.3	neutral	-3	neutral	0.65	deleterious	-1.54	low_impact	0.26	medium_impact	-0.28	medium_impact	0.43	0.85	NA	NA	0.48	N	0.03	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10768	10768	A	C	MI.16330	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	9	3	K	N	aaA/aaC	5.6	1	0	probably_damaging	1	deleterious	0.02	neutral	1.18	neutral	-2.97	deleterious	-3.66	medium_impact	3.31	0.63	neutral	0.09	damaging	3.61	23.20	deleterious	0.5	0.6	NA	NA	0.34	neutral	0.49	neutral	0.19	neutral	6	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.75	medium_impact	2.15	high_impact	0.37	0.8	47.93	9.67	0.64	P	0.72	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10769	10769	C	G	MI.16331	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	10	4	L	V	Cta/Gta	5.6	1	0	benign	0.32	neutral	0.3	neutral	1.45	neutral	-1.05	neutral	0.5	neutral_impact	-0.04	0.74	neutral	0.88	neutral	1.96	15.95	deleterious	0.26	0.45	NA	NA	0.1	neutral	0.16	neutral	0.26	neutral	5	0.64	neutral	0.49	deleterious	-6	neutral	0.71	deleterious	-0.41	medium_impact	0	medium_impact	-1.17	low_impact	0.47	0.8	27.67	29.01	0.66	P	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10769	10769	C	A	MI.16332	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	10	4	L	M	Cta/Ata	5.6	1	0	benign	0.11	neutral	0.07	neutral	1.38	neutral	-2.11	neutral	-0.55	neutral_impact	-0.39	0.75	neutral	0.86	neutral	2.63	20.40	deleterious	0.19	0.45	NA	NA	0.12	neutral	0.26	neutral	0.25	neutral	5	0.92	neutral	0.48	deleterious	-6	neutral	0.72	deleterious	0.14	medium_impact	-0.43	medium_impact	-1.51	low_impact	0.35	0.8	27.67	29.01	0.62	P	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10770	10770	T	A	MI.16333	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	11	4	L	Q	cTa/cAa	0.29	0.94	0	probably_damaging	0.9	deleterious	0	neutral	1.33	deleterious	-3.73	deleterious	-3.21	low_impact	1.2	0.67	neutral	0.6	neutral	4.08	23.70	deleterious	0.2	0.45	NA	NA	0.28	neutral	0.49	neutral	0.16	neutral	7	1	deleterious	0.05	neutral	2	deleterious	0.76	deleterious	-1.61	low_impact	-1.48	low_impact	0.06	medium_impact	0.22	0.8	27.67	29.01	0.45	N	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10770	10770	T	G	MI.16334	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	11	4	L	R	cTa/cGa	0.29	0.94	0	probably_damaging	0.9	deleterious	0	neutral	1.34	deleterious	-3.56	deleterious	-3.38	low_impact	1.2	0.63	neutral	0.55	neutral	4.06	23.70	deleterious	0.16	0.45	NA	NA	0.63	disease	0.62	disease	0.74	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.84	deleterious	-1.61	low_impact	-1.48	low_impact	0.06	medium_impact	0.23	0.8	27.67	29.01	0.37	N	0.78	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10770	10770	T	C	MI.16335	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	11	4	L	P	cTa/cCa	0.29	0.94	0	probably_damaging	0.95	deleterious	0	neutral	1.33	deleterious	-4.14	deleterious	-3.44	low_impact	1.2	0.58	damaging	0.44	neutral	3.84	23.40	deleterious	0.15	0.4	NA	NA	0.56	disease	0.64	disease	0.72	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.83	deleterious	-1.92	low_impact	-1.48	low_impact	0.06	medium_impact	0.21	0.8	27.67	29.01	0.4	N	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10772	10772	A	G	MI.16336	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	13	5	I	V	Atc/Gtc	-3.17	0	0	benign	0.05	neutral	0.08	neutral	1.37	neutral	-1.47	neutral	-0.67	low_impact	1.77	0.8	neutral	0.71	neutral	0.00	2.58	deleterious	0.32	0.5	NA	NA	0.12	neutral	0.33	neutral	0.27	neutral	5	0.91	neutral	0.52	deleterious	-6	neutral	0.12	neutral	0.48	medium_impact	-0.39	medium_impact	0.63	medium_impact	0.55	0.8	20.04	18.16	0.46	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10772	10772	A	T	MI.16337	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	13	5	I	F	Atc/Ttc	-3.17	0	0	probably_damaging	0.93	neutral	0.1	neutral	1.32	neutral	-2.15	neutral	-2.21	medium_impact	3.02	0.65	neutral	0.51	neutral	3.29	22.80	deleterious	0.14	0.4	NA	NA	0.28	neutral	0.48	neutral	0.2	neutral	6	0.97	neutral	0.09	neutral	1	deleterious	0.56	deleterious	-1.77	low_impact	-0.33	medium_impact	1.86	medium_impact	0.49	0.8	20.04	18.16	0.47	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10772	10772	A	C	MI.16338	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	13	5	I	L	Atc/Ctc	-3.17	0	0	benign	0.39	neutral	1	neutral	1.67	neutral	0.36	neutral	-0.26	low_impact	1.17	0.67	neutral	0.86	neutral	-0.91	0.03	neutral	0.19	0.45	NA	NA	0.04	neutral	0.17	neutral	0.22	neutral	6	0.39	neutral	0.81	deleterious	-6	neutral	0.13	neutral	-0.54	medium_impact	1.88	high_impact	0.03	medium_impact	0.54	0.8	20.04	18.16	0.4	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10773	10773	T	C	MI.16339	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	14	5	I	T	aTc/aCc	-0.17	0	0	possibly_damaging	0.75	deleterious	0.03	neutral	1.31	neutral	-2.39	deleterious	-2.98	medium_impact	2.21	0.63	neutral	0.64	neutral	1.62	13.96	neutral	0.19	0.45	NA	NA	0.23	neutral	0.58	disease	0.36	neutral	3	0.98	neutral	0.14	neutral	4	deleterious	0.40	neutral	-1.17	low_impact	-0.64	medium_impact	1.06	medium_impact	0.19	0.8	20.04	18.16	0.42	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8455	8455	C	G	MI.1634	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	90	30	N	K	aaC/aaG	0.36	0	0	probably_damaging	0.92	neutral	0.36	neutral	1.09	deleterious	-3.2	neutral	-0.39	neutral_impact	0.54	0.98	neutral	0.94	neutral	2.04	16.46	deleterious	0.91446772	0.95	0.17	neutral	0.29	neutral	0.24	neutral	0.22	neutral	6	0.92	neutral	0.22	neutral	-2	neutral	0.69	deleterious	-1.76	low_impact	0.15	medium_impact	-0.64	medium_impact	0.85	0.90	NA	NA	0.51	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10773	10773	T	A	MI.16340	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	14	5	I	N	aTc/aAc	-0.17	0	0	probably_damaging	0.96	deleterious	0	neutral	1.26	deleterious	-3.98	deleterious	-4.46	medium_impact	3.02	0.63	neutral	0.38	neutral	4.31	24.00	deleterious	0.19	0.45	NA	NA	0.43	neutral	0.62	disease	0.43	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.69	deleterious	-2.01	low_impact	-1.48	low_impact	1.86	medium_impact	0.21	0.8	20.04	18.16	0.38	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10773	10773	T	G	MI.16341	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	14	5	I	S	aTc/aGc	-0.17	0	0	probably_damaging	0.9	deleterious	0	neutral	1.29	neutral	-2.87	deleterious	-3.71	medium_impact	2.48	0.62	neutral	0.4	neutral	2.61	20.20	deleterious	0.16	0.45	NA	NA	0.42	neutral	0.59	disease	0.4	neutral	2	1	deleterious	0.05	neutral	5	deleterious	0.47	deleterious	-1.61	low_impact	-1.48	low_impact	1.33	medium_impact	0.28	0.8	20.04	18.16	0.39	N	0.93	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10774	10774	C	G	MI.16342	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	15	5	I	M	atC/atG	7.44	0.96	0	probably_damaging	0.93	neutral	0.06	neutral	1.32	neutral	-2.16	neutral	-1.16	medium_impact	3.02	0.74	neutral	0.56	neutral	2.95	22.10	deleterious	0.21	0.45	NA	NA	0.19	neutral	0.28	neutral	0.23	neutral	5	0.98	deleterious	0.07	neutral	1	deleterious	0.57	deleterious	-1.77	low_impact	-0.47	medium_impact	1.86	medium_impact	0.52	0.8	20.04	18.16	0.64	P	0.80	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10774	10774	C	A	MI.16343	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	15	5	I	M	atC/atA	7.44	0.96	0	probably_damaging	0.93	neutral	0.06	neutral	1.32	neutral	-2.16	neutral	-1.16	medium_impact	3.02	0.74	neutral	0.56	neutral	3.46	23.00	deleterious	0.21	0.45	NA	NA	0.19	neutral	0.28	neutral	0.23	neutral	5	0.98	deleterious	0.07	neutral	1	deleterious	0.57	deleterious	-1.77	low_impact	-0.47	medium_impact	1.86	medium_impact	0.52	0.8	20.04	18.16	0.64	P	0.80	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10775	10775	G	A	MI.16344	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	16	6	V	I	Gtc/Atc	-3.63	0	0	benign	0	neutral	1	neutral	1.62	neutral	0.25	neutral	0.57	neutral_impact	-1.85	0.72	neutral	1	neutral	-1.10	0.01	neutral	0.44	0.55	NA	NA	0.01	neutral	0.14	neutral	0.19	neutral	6	0	neutral	1	deleterious	-6	neutral	0.08	neutral	2.1	high_impact	1.88	high_impact	-2.96	low_impact	0.59	0.8	19.17	13.21	0.41	N	0.00	polymorphism	1	0.01	rs879015842	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10775	10775	G	T	MI.16345	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	16	6	V	F	Gtc/Ttc	-3.63	0	0	benign	0	neutral	0.57	neutral	1.55	neutral	-0.31	neutral	-1.36	neutral_impact	-0.84	0.83	neutral	0.94	neutral	0.74	9.11	deleterious	0.18	0.45	NA	NA	0.22	neutral	0.23	neutral	0.17	neutral	7	0.42	neutral	0.79	deleterious	-6	neutral	0.18	neutral	2.1	high_impact	0.27	medium_impact	-1.96	low_impact	0.30	0.8	19.17	13.21	0.3	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10775	10775	G	C	MI.16346	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	16	6	V	L	Gtc/Ctc	-3.63	0	0	benign	0	neutral	0.55	neutral	1.81	neutral	1.23	neutral	-0.1	neutral_impact	-0.74	0.77	neutral	0.97	neutral	0.17	4.37	deleterious	0.32	0.5	NA	NA	0.08	neutral	0.18	neutral	0.23	neutral	5	0.45	neutral	0.78	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.25	medium_impact	-1.86	low_impact	0.55	0.8	19.17	13.21	0.5	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10776	10776	T	C	MI.16347	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	17	6	V	A	gTc/gCc	-4.09	0	0	benign	0	deleterious	0	neutral	1.47	neutral	-1.36	neutral	-2.36	neutral_impact	0.4	0.76	neutral	0.96	neutral	1.57	13.71	neutral	0.25	0.45	NA	NA	0.11	neutral	0.49	neutral	0.21	neutral	6	1	deleterious	0.5	deleterious	-2	neutral	0.11	neutral	2.1	high_impact	-1.48	low_impact	-0.73	medium_impact	0.26	0.8	19.17	13.21	0.45	N	0.03	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10776	10776	T	A	MI.16348	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	17	6	V	D	gTc/gAc	-4.09	0	0	benign	0.27	deleterious	0	neutral	1.4	deleterious	-4.37	deleterious	-3.95	low_impact	1.1	0.68	neutral	0.47	neutral	2.66	20.60	deleterious	0.13	0.4	NA	NA	0.44	neutral	0.64	disease	0.41	neutral	2	1	deleterious	0.37	neutral	-2	neutral	0.34	neutral	-0.31	medium_impact	-1.48	low_impact	-0.04	medium_impact	0.12	0.8	19.17	13.21	0.36	N	0.39	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10776	10776	T	G	MI.16349	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	17	6	V	G	gTc/gGc	-4.09	0	0	benign	0.1	deleterious	0.03	neutral	1.41	deleterious	-3.25	deleterious	-4.4	low_impact	1.1	0.73	neutral	0.55	neutral	1.88	15.50	deleterious	0.18	0.45	NA	NA	0.24	neutral	0.52	disease	0.31	neutral	4	0.97	neutral	0.47	neutral	-2	neutral	0.17	neutral	0.18	medium_impact	-0.64	medium_impact	-0.04	medium_impact	0.17	0.8	19.17	13.21	0.43	N	0.37	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8455	8455	C	A	MI.1635	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	90	30	N	K	aaC/aaA	0.36	0	0	probably_damaging	0.92	neutral	0.36	neutral	1.09	deleterious	-3.2	neutral	-0.39	neutral_impact	0.54	0.98	neutral	0.94	neutral	2.46	19.21	deleterious	0.91446772	0.95	0.17	neutral	0.29	neutral	0.24	neutral	0.22	neutral	6	0.92	neutral	0.22	neutral	-2	neutral	0.69	deleterious	-1.76	low_impact	0.15	medium_impact	-0.64	medium_impact	0.85	0.90	NA	NA	0.53	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10778	10778	C	A	MI.16350	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	19	7	P	T	Cca/Aca	-7.78	0	0	probably_damaging	0.91	neutral	0.25	neutral	1.41	neutral	-1.9	deleterious	-5.45	medium_impact	2.58	0.76	neutral	0.54	neutral	3.64	23.20	deleterious	0.23	0.45	NA	NA	0.43	neutral	0.63	disease	0.39	neutral	2	0.93	neutral	0.17	neutral	1	deleterious	0.77	deleterious	-1.66	low_impact	-0.07	medium_impact	1.43	medium_impact	0.54	0.8	45.1	8.54	0.38	N	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10778	10778	C	T	MI.16351	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	19	7	P	S	Cca/Tca	-7.78	0	0	benign	0.42	neutral	0.29	neutral	1.42	neutral	-1.58	deleterious	-5.33	medium_impact	3.04	0.77	neutral	0.76	neutral	3.85	23.40	deleterious	0.25	0.45	NA	NA	0.43	neutral	0.45	neutral	0.19	neutral	6	0.66	neutral	0.44	neutral	-3	neutral	0.78	deleterious	-0.59	medium_impact	-0.02	medium_impact	1.88	medium_impact	0.33	0.8	45.1	8.54	0.42	N	0.71	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10778	10778	C	G	MI.16352	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	19	7	P	A	Cca/Gca	-7.78	0	0	possibly_damaging	0.86	neutral	0.38	neutral	1.48	neutral	-0.81	deleterious	-5.45	medium_impact	2.42	0.82	neutral	0.64	neutral	3.04	22.30	deleterious	0.25	0.45	NA	NA	0.32	neutral	0.48	neutral	0.17	neutral	7	0.86	neutral	0.26	neutral	0	NA	0.76	deleterious	-1.46	low_impact	0.08	medium_impact	1.27	medium_impact	0.63	0.8	45.1	8.54	0.37	N	0.77	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10779	10779	C	G	MI.16353	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	20	7	P	R	cCa/cGa	1.44	0.57	0	probably_damaging	0.97	neutral	0.2	neutral	1.37	deleterious	-3.1	deleterious	-6.25	medium_impact	3.38	0.67	neutral	0.42	neutral	3.58	23.20	deleterious	0.15	0.4	NA	NA	0.73	disease	0.76	disease	0.75	disease	5	0.98	neutral	0.12	neutral	1	deleterious	0.84	deleterious	-2.14	low_impact	-0.14	medium_impact	2.22	high_impact	0.36	0.8	45.1	8.54	0.39	N	0.58	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10779	10779	C	A	MI.16354	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	20	7	P	Q	cCa/cAa	1.44	0.57	0	probably_damaging	0.98	neutral	0.17	neutral	1.36	deleterious	-3.16	deleterious	-5.51	medium_impact	3.38	0.72	neutral	0.4	neutral	4.10	23.70	deleterious	0.18	0.45	NA	NA	0.6	disease	0.68	disease	0.68	disease	4	0.99	deleterious	0.1	neutral	1	deleterious	0.79	deleterious	-2.31	low_impact	-0.18	medium_impact	2.22	high_impact	0.41	0.8	45.1	8.54	0.39	N	0.84	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10779	10779	C	T	MI.16355	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	20	7	P	L	cCa/cTa	1.44	0.57	0	probably_damaging	0.97	neutral	0.42	neutral	1.5	neutral	-0.64	deleterious	-6.99	medium_impact	3.38	0.71	neutral	0.43	neutral	4.38	24.10	deleterious	0.15	0.4	NA	NA	0.64	disease	0.63	disease	0.67	disease	3	0.97	neutral	0.23	neutral	1	deleterious	0.80	deleterious	-2.14	low_impact	0.12	medium_impact	2.22	high_impact	0.56	0.8	45.1	8.54	0.37	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10781	10781	A	T	MI.16356	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	22	8	T	S	Aca/Tca	-13.77	0	0	possibly_damaging	0.85	neutral	0.19	neutral	1.41	neutral	-1.48	deleterious	-2.69	low_impact	1.29	0.79	neutral	0.87	neutral	2.06	16.62	deleterious	0.21	0.45	NA	NA	0.3	neutral	0.39	neutral	0.16	neutral	7	0.91	neutral	0.17	neutral	-3	neutral	0.75	deleterious	-1.43	low_impact	-0.15	medium_impact	0.15	medium_impact	0.60	0.8	18.3	18.48	0.47	N	0.25	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10781	10781	A	C	MI.16357	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	22	8	T	P	Aca/Cca	-13.77	0	0	probably_damaging	0.98	deleterious	0.01	neutral	1.32	deleterious	-4.12	deleterious	-4.29	medium_impact	2.77	0.63	neutral	0.35	neutral	3.31	22.90	deleterious	0.1	0.4	NA	NA	0.65	disease	0.75	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.81	deleterious	-2.31	low_impact	-0.92	medium_impact	1.61	medium_impact	0.44	0.8	18.3	18.48	0.35	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10781	10781	A	G	MI.16358	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	22	8	T	A	Aca/Gca	-13.77	0	0	possibly_damaging	0.74	deleterious	0.04	neutral	1.39	neutral	-1.76	deleterious	-3.51	medium_impact	3.12	0.8	neutral	0.55	neutral	3.29	22.80	deleterious	0.24	0.45	NA	NA	0.37	neutral	0.63	disease	0.39	neutral	2	0.97	neutral	0.15	neutral	4	deleterious	0.75	deleterious	-1.14	low_impact	-0.57	medium_impact	1.96	medium_impact	0.20	0.8	18.3	18.48	0.44	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10782	10782	C	A	MI.16359	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	23	8	T	K	aCa/aAa	3.75	0.99	0	probably_damaging	0.94	deleterious	0.02	neutral	1.33	deleterious	-3.36	deleterious	-4.25	medium_impact	3.12	0.71	neutral	0.38	neutral	4.27	24.00	deleterious	0.12	0.4	NA	NA	0.7	disease	0.74	disease	0.74	disease	5	0.99	deleterious	0.04	neutral	5	deleterious	0.81	deleterious	-1.84	low_impact	-0.75	medium_impact	1.96	medium_impact	0.37	0.8	18.3	18.48	0.54	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8456	8456	A	C	MI.1636	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	91	31	T	P	Aca/Cca	-9.36	0	0	benign	0.07	neutral	0.21	neutral	0.53	deleterious	-6.41	neutral	-1.96	low_impact	1.73	0.99	neutral	0.41	neutral	0.12	3.82	deleterious	0.13551864	0.85	0.43	neutral	0.44	neutral	0.32	neutral	0.21	neutral	6	0.77	neutral	0.57	deleterious	-6	neutral	0.22	neutral	0.31	medium_impact	-0.03	medium_impact	0.39	medium_impact	0.53	0.85	4.41	7.27	0.52	N	0.30	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10782	10782	C	T	MI.16360	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	23	8	T	M	aCa/aTa	3.75	0.99	0	possibly_damaging	0.52	neutral	0.3	neutral	1.4	neutral	-1.58	deleterious	-4.26	medium_impact	2.43	0.83	neutral	0.6	neutral	3.69	23.30	deleterious	0.15	0.45	NA	NA	0.49	neutral	0.55	disease	0.41	neutral	2	0.68	neutral	0.39	neutral	0	NA	0.75	deleterious	-0.75	medium_impact	0	medium_impact	1.28	medium_impact	0.39	0.8	18.3	18.48	0.6	P	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10784	10784	A	C	MI.16361	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	25	9	I	L	Att/Ctt	-5.7	0	0	benign	0.03	neutral	1	neutral	1.64	neutral	-0.01	neutral	-0.53	neutral_impact	0.56	0.76	neutral	0.97	neutral	-0.27	0.77	neutral	0.18	0.45	NA	NA	0.13	neutral	0.19	neutral	0.24	neutral	5	0.03	neutral	0.99	deleterious	-6	neutral	0.10	neutral	0.7	medium_impact	1.88	high_impact	-0.57	medium_impact	0.51	0.8	21.35	11.49	0.38	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10784	10784	A	G	MI.16362	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	25	9	I	V	Att/Gtt	-5.7	0	0	benign	0.01	neutral	0.17	neutral	1.52	neutral	0.03	neutral	-0.49	medium_impact	2.1	0.83	neutral	0.93	neutral	-0.23	0.96	neutral	0.2	0.45	NA	NA	0.11	neutral	0.29	neutral	0.26	neutral	5	0.83	neutral	0.58	deleterious	-3	neutral	0.07	neutral	1.16	medium_impact	-0.18	medium_impact	0.95	medium_impact	0.34	0.8	21.35	11.49	0.49	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10784	10784	A	T	MI.16363	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	25	9	I	F	Att/Ttt	-5.7	0	0	benign	0.38	neutral	0.17	neutral	1.43	neutral	-2.23	neutral	-1.89	low_impact	1.84	0.79	neutral	0.9	neutral	1.01	10.73	neutral	0.14	0.4	NA	NA	0.29	neutral	0.3	neutral	0.21	neutral	6	0.8	neutral	0.4	neutral	-6	neutral	0.43	neutral	-0.52	medium_impact	-0.18	medium_impact	0.69	medium_impact	0.48	0.8	21.35	11.49	0.46	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10785	10785	T	C	MI.16364	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	26	9	I	T	aTt/aCt	-2.24	0	0	benign	0.01	neutral	0.13	neutral	1.4	neutral	-2.38	neutral	-2.49	low_impact	1.13	0.79	neutral	0.98	neutral	0.10	3.62	deleterious	0.13	0.4	NA	NA	0.19	neutral	0.35	neutral	0.21	neutral	6	0.87	neutral	0.56	deleterious	-6	neutral	0.11	neutral	1.16	medium_impact	-0.26	medium_impact	-0.01	medium_impact	0.21	0.8	21.35	11.49	0.48	N	0.37	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10785	10785	T	A	MI.16365	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	26	9	I	N	aTt/aAt	-2.24	0	0	benign	0.38	deleterious	0.01	neutral	1.34	deleterious	-3.82	deleterious	-4.01	medium_impact	2.65	0.77	neutral	0.52	neutral	2.56	19.88	deleterious	0.12	0.4	NA	NA	0.49	neutral	0.6	disease	0.68	disease	4	0.99	deleterious	0.32	neutral	1	deleterious	0.43	neutral	-0.52	medium_impact	-0.92	medium_impact	1.5	medium_impact	0.12	0.8	21.35	11.49	0.39	N	0.89	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10785	10785	T	G	MI.16366	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	26	9	I	S	aTt/aGt	-2.24	0	0	benign	0.18	deleterious	0.02	neutral	1.38	neutral	-2.87	deleterious	-3.25	medium_impact	2.1	0.76	neutral	0.66	neutral	2.13	17.05	deleterious	0.06	0.35	NA	NA	0.47	neutral	0.5	neutral	0.33	neutral	3	0.98	neutral	0.42	neutral	1	deleterious	0.24	neutral	-0.1	medium_impact	-0.75	medium_impact	0.95	medium_impact	0.19	0.8	21.35	11.49	0.42	N	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10786	10786	T	A	MI.16367	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	27	9	I	M	atT/atA	0.75	0	0	benign	0.03	neutral	0.16	neutral	1.44	neutral	-2.32	neutral	-1.04	neutral_impact	0.68	0.83	neutral	0.99	neutral	1.71	14.44	neutral	0.21	0.45	NA	NA	0.16	neutral	0.23	neutral	0.24	neutral	5	0.83	neutral	0.57	deleterious	-6	neutral	0.44	deleterious	0.7	medium_impact	-0.2	medium_impact	-0.45	medium_impact	0.52	0.8	21.35	11.49	0.53	P	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10786	10786	T	G	MI.16368	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	27	9	I	M	atT/atG	0.75	0	0	benign	0.03	neutral	0.16	neutral	1.44	neutral	-2.32	neutral	-1.04	neutral_impact	0.68	0.83	neutral	0.99	neutral	1.38	12.67	neutral	0.21	0.45	NA	NA	0.16	neutral	0.23	neutral	0.24	neutral	5	0.83	neutral	0.57	deleterious	-6	neutral	0.44	deleterious	0.7	medium_impact	-0.2	medium_impact	-0.45	medium_impact	0.52	0.8	21.35	11.49	0.53	P	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10787	10787	A	G	MI.16369	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	28	10	M	V	Ata/Gta	-14.24	0	0	benign	0.22	neutral	0.05	neutral	1.49	neutral	-0.85	deleterious	-2.88	medium_impact	3.37	0.63	neutral	0.55	neutral	2.49	19.42	deleterious	0.17	0.45	NA	NA	0.65	disease	0.67	disease	0.68	disease	4	0.94	neutral	0.42	neutral	-3	neutral	0.71	deleterious	-0.2	medium_impact	-0.52	medium_impact	2.21	high_impact	0.38	0.8	45.53	8.91	0.47	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8456	8456	A	G	MI.1637	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	91	31	T	A	Aca/Gca	-9.36	0	0	benign	0.01	neutral	0.5	neutral	0.56	deleterious	-5.07	neutral	-0.88	low_impact	1.73	1	neutral	0.74	neutral	-0.50	0.22	neutral	0.81027320	0.90	0.2	neutral	0.13	neutral	0.33	neutral	0.1	neutral	8	0.49	neutral	0.75	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.29	medium_impact	0.39	medium_impact	0.38	0.85	4.41	7.27	0.43	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10787	10787	A	C	MI.16370	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	28	10	M	L	Ata/Cta	-14.24	0	0	benign	0.16	neutral	0.17	neutral	1.55	neutral	-0.27	neutral	-2.09	medium_impact	2.47	0.8	neutral	0.75	neutral	2.94	22.00	deleterious	0.17	0.45	NA	NA	0.56	disease	0.41	neutral	0.45	neutral	1	0.8	neutral	0.51	deleterious	-3	neutral	0.62	deleterious	-0.04	medium_impact	-0.18	medium_impact	1.32	medium_impact	0.36	0.8	45.53	8.91	0.4	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10787	10787	A	T	MI.16371	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	28	10	M	L	Ata/Tta	-14.24	0	0	benign	0.16	neutral	0.17	neutral	1.55	neutral	-0.27	neutral	-2.09	medium_impact	2.47	0.8	neutral	0.75	neutral	3.01	22.30	deleterious	0.17	0.45	NA	NA	0.56	disease	0.41	neutral	0.45	neutral	1	0.8	neutral	0.51	deleterious	-3	neutral	0.62	deleterious	-0.04	medium_impact	-0.18	medium_impact	1.32	medium_impact	0.36	0.8	45.53	8.91	0.41	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10788	10788	T	C	MI.16372	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	29	10	M	T	aTa/aCa	1.91	0.77	0	possibly_damaging	0.71	deleterious	0.04	neutral	1.45	neutral	-1.43	deleterious	-4.36	medium_impact	2.47	0.8	neutral	0.64	neutral	2.63	20.40	deleterious	0.14	0.4	NA	NA	0.62	disease	0.51	disease	0.46	neutral	1	0.97	neutral	0.17	neutral	4	deleterious	0.79	deleterious	-1.08	low_impact	-0.57	medium_impact	1.32	medium_impact	0.10	0.8	45.53	8.91	0.37	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10788	10788	T	A	MI.16373	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	29	10	M	K	aTa/aAa	1.91	0.77	0	possibly_damaging	0.86	deleterious	0.01	neutral	1.39	neutral	-2.85	deleterious	-4.39	medium_impact	3.37	0.64	neutral	0.42	neutral	3.66	23.20	deleterious	0.05	0.35	NA	NA	0.81	disease	0.73	disease	0.75	disease	5	0.99	deleterious	0.08	neutral	4	deleterious	0.84	deleterious	-1.46	low_impact	-0.92	medium_impact	2.21	high_impact	0.19	0.8	45.53	8.91	0.39	N	1.00	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10789	10789	A	T	MI.16374	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	30	10	M	I	atA/atT	3.75	0.86	0	benign	0.04	deleterious	0.03	neutral	1.45	neutral	-1.29	deleterious	-2.86	medium_impact	2.82	0.67	neutral	0.59	neutral	3.16	22.60	deleterious	0.2	0.45	NA	NA	0.65	disease	0.58	disease	0.59	disease	2	0.97	neutral	0.5	deleterious	1	deleterious	0.75	deleterious	0.58	medium_impact	-0.64	medium_impact	1.66	medium_impact	0.44	0.8	45.53	8.91	0.46	N	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10789	10789	A	C	MI.16375	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	30	10	M	I	atA/atC	3.75	0.86	0	benign	0.04	deleterious	0.03	neutral	1.45	neutral	-1.29	deleterious	-2.86	medium_impact	2.82	0.67	neutral	0.59	neutral	3.14	22.60	deleterious	0.2	0.45	NA	NA	0.65	disease	0.58	disease	0.59	disease	2	0.97	neutral	0.5	deleterious	1	deleterious	0.75	deleterious	0.58	medium_impact	-0.64	medium_impact	1.66	medium_impact	0.44	0.8	45.53	8.91	0.45	N	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10790	10790	T	A	MI.16376	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	31	11	L	M	Tta/Ata	0.06	0.02	0.02	possibly_damaging	0.76	neutral	0.29	neutral	1.03	neutral	-2.55	neutral	-1.37	medium_impact	1.97	0.75	neutral	0.33	neutral	2.28	18.01	deleterious	0.17	0.45	NA	NA	0.26	neutral	0.27	neutral	0.19	neutral	6	0.82	neutral	0.27	neutral	0	NA	0.75	deleterious	-1.19	low_impact	-0.02	medium_impact	0.82	medium_impact	0.37	0.8	13.73	9.93	0.43	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10790	10790	T	G	MI.16377	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	31	11	L	V	Tta/Gta	0.06	0.02	0.02	possibly_damaging	0.9	neutral	0.05	neutral	1.02	neutral	-2.64	neutral	-2.16	medium_impact	3.35	0.67	neutral	0.14	damaging	3.20	22.70	deleterious	0.19	0.45	NA	NA	0.41	neutral	0.63	disease	0.38	neutral	2	0.98	deleterious	0.08	neutral	0	NA	0.80	deleterious	-1.61	low_impact	-0.52	medium_impact	2.19	high_impact	0.53	0.8	13.73	9.93	0.41	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10791	10791	T	G	MI.16378	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	32	11	L	W	tTa/tGa	-0.17	0.02	0	probably_damaging	1	deleterious	0	neutral	0.89	deleterious	-6.65	deleterious	-4.38	medium_impact	3.35	0.59	damaging	0.14	damaging	3.52	23.10	deleterious	0.07	0.35	NA	NA	0.62	disease	0.66	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.19	high_impact	0.16	0.8	13.73	9.93	0.33	N	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10791	10791	T	C	MI.16379	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	32	11	L	S	tTa/tCa	-0.17	0.02	0	probably_damaging	0.98	deleterious	0.03	neutral	0.94	deleterious	-4.04	deleterious	-4.36	medium_impact	2.8	0.63	neutral	0.14	damaging	3.57	23.10	deleterious	0.09	0.35	NA	NA	0.6	disease	0.63	disease	0.67	disease	3	1	deleterious	0.03	neutral	5	deleterious	0.83	deleterious	-2.31	low_impact	-0.64	medium_impact	1.64	medium_impact	0.24	0.8	13.73	9.93	0.31	N	0.95	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8456	8456	A	T	MI.1638	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	91	31	T	S	Aca/Tca	-9.36	0	0	benign	0	neutral	0.41	neutral	0.7	neutral	-2.93	neutral	0.01	neutral_impact	0.42	1	neutral	0.93	neutral	-0.54	0.17	neutral	0.66698427	0.85	0.19	neutral	0.1	neutral	0.32	neutral	0.04	neutral	9	0.59	neutral	0.71	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	0.2	medium_impact	-0.74	medium_impact	0.59	0.85	4.41	7.27	0.48	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10792	10792	A	C	MI.16380	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	33	11	L	F	ttA/ttC	7.44	0.96	0	probably_damaging	0.98	deleterious	0	neutral	0.96	deleterious	-3.6	deleterious	-2.91	medium_impact	3	0.63	neutral	0.14	damaging	3.23	22.80	deleterious	0.16	0.45	NA	NA	0.47	neutral	0.53	disease	0.4	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-2.31	low_impact	-1.48	low_impact	1.84	medium_impact	0.52	0.8	13.73	9.93	0.56	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10792	10792	A	T	MI.16381	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	33	11	L	F	ttA/ttT	7.44	0.96	0	probably_damaging	0.98	deleterious	0	neutral	0.96	deleterious	-3.6	deleterious	-2.91	medium_impact	3	0.63	neutral	0.14	damaging	3.37	22.90	deleterious	0.16	0.45	NA	NA	0.47	neutral	0.53	disease	0.4	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-2.31	low_impact	-1.48	low_impact	1.84	medium_impact	0.52	0.8	13.73	9.93	0.57	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10793	10793	C	A	MI.16382	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	34	12	L	M	Cta/Ata	-9.39	0	0	benign	0.4	neutral	0.25	neutral	1.48	neutral	-1	neutral	-0.61	low_impact	0.88	0.83	neutral	0.99	neutral	2.16	17.25	deleterious	0.17	0.45	NA	NA	0.2	neutral	0.18	neutral	0.22	neutral	6	0.71	neutral	0.43	neutral	-6	neutral	0.71	deleterious	-0.55	medium_impact	-0.07	medium_impact	-0.26	medium_impact	0.47	0.8	23.97	36.9	0.55	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10793	10793	C	G	MI.16383	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	34	12	L	V	Cta/Gta	-9.39	0	0	benign	0.4	neutral	0.29	neutral	1.51	neutral	-0.61	neutral	-0.58	low_impact	1.82	0.8	neutral	0.96	neutral	1.95	15.87	deleterious	0.16	0.45	NA	NA	0.25	neutral	0.21	neutral	0.2	neutral	6	0.66	neutral	0.45	neutral	-6	neutral	0.71	deleterious	-0.55	medium_impact	-0.02	medium_impact	0.68	medium_impact	0.49	0.8	23.97	36.9	0.47	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10794	10794	T	C	MI.16384	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	35	12	L	P	cTa/cCa	-2.48	0	0	probably_damaging	0.96	deleterious	0	neutral	1.38	deleterious	-3.77	deleterious	-3.87	medium_impact	2.62	0.56	damaging	0.39	neutral	3.72	23.30	deleterious	0.06	0.35	NA	NA	0.78	disease	0.65	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-2.01	low_impact	-1.48	low_impact	1.47	medium_impact	0.23	0.8	23.97	36.9	0.33	N	0.93	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10794	10794	T	G	MI.16385	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	35	12	L	R	cTa/cGa	-2.48	0	0	probably_damaging	0.93	deleterious	0	neutral	1.39	deleterious	-3.18	deleterious	-3.45	medium_impact	2.27	0.65	neutral	0.47	neutral	3.93	23.50	deleterious	0.05	0.35	NA	NA	0.77	disease	0.65	disease	0.76	disease	5	1	deleterious	0.04	neutral	5	deleterious	0.83	deleterious	-1.77	low_impact	-1.48	low_impact	1.12	medium_impact	0.17	0.8	23.97	36.9	0.32	N	0.93	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10794	10794	T	A	MI.16386	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	35	12	L	Q	cTa/cAa	-2.48	0	0	probably_damaging	0.93	deleterious	0	neutral	1.39	deleterious	-3.34	deleterious	-3.38	medium_impact	2.62	0.7	neutral	0.54	neutral	4.00	23.60	deleterious	0.07	0.35	NA	NA	0.57	disease	0.51	disease	0.57	disease	1	1	deleterious	0.04	neutral	5	deleterious	0.75	deleterious	-1.77	low_impact	-1.48	low_impact	1.47	medium_impact	0.21	0.8	23.97	36.9	0.41	N	0.89	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10796	10796	C	T	MI.16387	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	37	13	P	S	Cca/Tca	-7.32	0	0	probably_damaging	1	deleterious	0.01	neutral	1.33	neutral	-2.19	deleterious	-5.8	medium_impact	3.46	0.62	neutral	0.17	damaging	3.66	23.20	deleterious	0.18	0.45	NA	NA	0.68	disease	0.62	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-3.54	low_impact	-0.92	medium_impact	2.3	high_impact	0.27	0.8	45.97	8.92	0.31	N	0.71	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10796	10796	C	G	MI.16388	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	37	13	P	A	Cca/Gca	-7.32	0	0	probably_damaging	1	deleterious	0.03	neutral	1.33	neutral	-2.14	deleterious	-5.78	medium_impact	3.12	0.64	neutral	0.2	damaging	2.83	21.50	deleterious	0.19	0.45	NA	NA	0.53	disease	0.64	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.64	medium_impact	1.96	medium_impact	0.64	0.8	45.97	8.92	0.31	N	0.77	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10796	10796	C	A	MI.16389	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	37	13	P	T	Cca/Aca	-7.32	0	0	probably_damaging	1	neutral	0.06	neutral	1.32	neutral	-2.27	deleterious	-5.78	medium_impact	3.46	0.65	neutral	0.14	damaging	3.45	23.00	deleterious	0.17	0.45	NA	NA	0.66	disease	0.57	disease	0.66	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.47	medium_impact	2.3	high_impact	0.58	0.8	45.97	8.92	0.33	N	0.89	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8457	8457	C	A	MI.1639	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	92	31	T	K	aCa/aAa	-0.8	0	0	benign	0.02	neutral	0.3	neutral	0.54	deleterious	-5.78	neutral	-1.09	low_impact	1.73	0.99	neutral	0.57	neutral	0.98	10.53	neutral	0.35296026	0.85	0.18	neutral	0.34	neutral	0.39	neutral	0.16	neutral	7	0.69	neutral	0.64	deleterious	-6	neutral	0.17	neutral	0.85	medium_impact	0.08	medium_impact	0.39	medium_impact	0.58	0.85	4.41	7.27	0.53	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10797	10797	C	G	MI.16390	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	38	13	P	R	cCa/cGa	4.21	0.98	0	probably_damaging	1	deleterious	0.01	neutral	1.28	deleterious	-3.64	deleterious	-6.53	medium_impact	3.46	0.64	neutral	0.15	damaging	3.29	22.80	deleterious	0.1	0.4	NA	NA	0.83	disease	0.75	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.87	deleterious	-3.54	low_impact	-0.92	medium_impact	2.3	high_impact	0.43	0.8	45.97	8.92	0.52	N	0.58	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10797	10797	C	T	MI.16391	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	38	13	P	L	cCa/cTa	4.21	0.98	0	probably_damaging	1	neutral	0.47	neutral	1.46	neutral	-0.71	deleterious	-7.16	medium_impact	2.91	0.69	neutral	0.2	damaging	4.06	23.70	deleterious	0.12	0.4	NA	NA	0.75	disease	0.44	neutral	0.51	disease	0	1	deleterious	0.24	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.17	medium_impact	1.75	medium_impact	0.68	0.85	45.97	8.92	0.51	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10797	10797	C	A	MI.16392	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	38	13	P	Q	cCa/cAa	4.21	0.98	0	probably_damaging	1	deleterious	0.02	neutral	1.28	deleterious	-3.51	deleterious	-5.8	medium_impact	3.46	0.64	neutral	0.14	damaging	3.88	23.50	deleterious	0.12	0.4	NA	NA	0.78	disease	0.69	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.75	medium_impact	2.3	high_impact	0.46	0.8	45.97	8.92	0.53	P	0.84	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10799	10799	C	A	MI.16393	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	40	14	L	M	Ctg/Atg	-13.08	0	0	benign	0.08	neutral	0.33	neutral	1.42	neutral	-1.27	neutral	-0.49	low_impact	1.12	0.82	neutral	0.96	neutral	2.23	17.69	deleterious	0.19	0.45	NA	NA	0.18	neutral	0.22	neutral	0.23	neutral	5	0.63	neutral	0.63	deleterious	-6	neutral	0.72	deleterious	0.28	medium_impact	0.03	medium_impact	-0.02	medium_impact	0.51	0.8	25.05	19.07	0.43	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10799	10799	C	G	MI.16394	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	40	14	L	V	Ctg/Gtg	-13.08	0	0	benign	0.04	neutral	0.57	neutral	1.44	neutral	-1.05	neutral	-0.82	medium_impact	2.36	0.74	neutral	0.86	neutral	1.25	12.02	neutral	0.18	0.45	NA	NA	0.36	neutral	0.26	neutral	0.2	neutral	6	0.38	neutral	0.77	deleterious	-3	neutral	0.74	deleterious	0.58	medium_impact	0.27	medium_impact	1.21	medium_impact	0.49	0.8	25.05	19.07	0.42	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10800	10800	T	G	MI.16395	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	41	14	L	R	cTg/cGg	-1.09	0	0	possibly_damaging	0.75	neutral	0.15	neutral	1.31	deleterious	-3.58	deleterious	-2.73	medium_impact	2.71	0.61	neutral	0.41	neutral	3.88	23.50	deleterious	0.06	0.35	NA	NA	0.83	disease	0.71	disease	0.79	disease	6	0.89	neutral	0.2	neutral	0	NA	0.85	deleterious	-1.17	low_impact	-0.22	medium_impact	1.56	medium_impact	0.20	0.8	25.05	19.07	0.35	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10800	10800	T	C	MI.16396	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	41	14	L	P	cTg/cCg	-1.09	0	0	possibly_damaging	0.87	neutral	0.11	neutral	1.31	deleterious	-4.21	deleterious	-3.15	medium_impact	2.71	0.56	damaging	0.33	neutral	2.63	20.40	deleterious	0.07	0.35	NA	NA	0.81	disease	0.65	disease	0.77	disease	5	0.95	neutral	0.12	neutral	0	NA	0.84	deleterious	-1.49	low_impact	-0.31	medium_impact	1.56	medium_impact	0.18	0.8	25.05	19.07	0.33	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10800	10800	T	A	MI.16397	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	41	14	L	Q	cTg/cAg	-1.09	0	0	possibly_damaging	0.83	neutral	0.15	neutral	1.31	deleterious	-3.73	deleterious	-2.61	medium_impact	2.71	0.67	neutral	0.47	neutral	3.95	23.60	deleterious	0.08	0.35	NA	NA	0.6	disease	0.5	neutral	0.51	disease	0	0.92	neutral	0.16	neutral	0	NA	0.76	deleterious	-1.37	low_impact	-0.22	medium_impact	1.56	medium_impact	0.22	0.8	25.05	19.07	0.44	N	0.85	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10802	10802	A	G	MI.16398	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	43	15	T	A	Aca/Gca	-7.78	0	0	possibly_damaging	0.64	neutral	0.82	neutral	1.55	neutral	-0.37	neutral	-2.1	low_impact	1.46	0.78	neutral	0.88	neutral	2.02	16.33	deleterious	0.19	0.45	NA	NA	0.19	neutral	0.29	neutral	0.21	neutral	6	0.57	neutral	0.59	deleterious	-3	neutral	0.70	deleterious	-0.95	medium_impact	0.57	medium_impact	0.32	medium_impact	0.48	0.8	17.65	14.93	0.27	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10802	10802	A	C	MI.16399	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	43	15	T	P	Aca/Cca	-7.78	0	0	benign	0.12	neutral	0.13	neutral	1.44	neutral	-2.38	deleterious	-3.25	medium_impact	2.69	0.73	neutral	0.4	neutral	3.26	22.80	deleterious	0.07	0.35	NA	NA	0.77	disease	0.7	disease	0.76	disease	5	0.85	neutral	0.51	deleterious	-3	neutral	0.80	deleterious	0.1	medium_impact	-0.26	medium_impact	1.54	medium_impact	0.38	0.8	17.65	14.93	0.36	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8603	8603	T	G	MI.164	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	77	26	F	C	tTt/tGt	-0.33	0	0	possibly_damaging	0.78	deleterious	0	neutral	4.23	deleterious	-3.24	deleterious	-4.5	medium_impact	2.19	0.76	neutral	0.48	neutral	3.77	23.40	deleterious	0.27	0.65	0.85	disease	0.63	disease	0.53	disease	0.65	disease	3	1	deleterious	0.11	neutral	4	deleterious	0.69	deleterious	-1.28	low_impact	-1.4	low_impact	0.78	medium_impact	0.28	0.9	15.49	8.03	0.31	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8457	8457	C	T	MI.1640	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	92	31	T	M	aCa/aTa	-0.8	0	0	benign	0.36	neutral	0.22	neutral	0.53	deleterious	-6.26	neutral	-0.28	neutral_impact	0.42	1	neutral	0.67	neutral	0.82	9.61	deleterious	0.44957237	0.85	0.42	neutral	0.12	neutral	0.21	neutral	0.08	neutral	9	0.74	neutral	0.43	neutral	-6	neutral	0.30	neutral	-0.52	medium_impact	-0.02	medium_impact	-0.74	medium_impact	0.61	0.85	4.41	7.27	0.55	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10802	10802	A	T	MI.16400	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	43	15	T	S	Aca/Tca	-7.78	0	0	possibly_damaging	0.8	neutral	0.43	neutral	1.55	neutral	-0.3	neutral	-2.02	medium_impact	2.35	0.72	neutral	0.76	neutral	1.94	15.85	deleterious	0.23	0.45	NA	NA	0.36	neutral	0.28	neutral	0.2	neutral	6	0.8	neutral	0.32	neutral	0	NA	0.72	deleterious	-1.28	low_impact	0.13	medium_impact	1.2	medium_impact	0.68	0.85	17.65	14.93	0.47	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10803	10803	C	A	MI.16401	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	44	15	T	K	aCa/aAa	0.29	0	0	possibly_damaging	0.88	neutral	0.07	neutral	1.45	neutral	-1.91	deleterious	-3.21	medium_impact	3.04	0.72	neutral	0.38	neutral	4.20	23.90	deleterious	0.08	0.35	NA	NA	0.71	disease	0.69	disease	0.74	disease	5	0.97	neutral	0.1	neutral	0	NA	0.78	deleterious	-1.53	low_impact	-0.43	medium_impact	1.88	medium_impact	0.44	0.8	17.65	14.93	0.42	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10803	10803	C	T	MI.16402	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	44	15	T	M	aCa/aTa	0.29	0	0	possibly_damaging	0.52	neutral	0.12	neutral	1.46	neutral	-1.68	neutral	-2.27	medium_impact	2.15	0.78	neutral	0.81	neutral	3.78	23.40	deleterious	0.08	0.35	NA	NA	0.5	neutral	0.49	neutral	0.48	neutral	0	0.87	neutral	0.3	neutral	0	NA	0.72	deleterious	-0.75	medium_impact	-0.28	medium_impact	1	medium_impact	0.59	0.8	17.65	14.93	0.41	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10805	10805	T	G	MI.16403	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	46	16	W	G	Tga/Gga	-4.78	0	0	probably_damaging	1	deleterious	0.02	neutral	1.5	neutral	-1.97	deleterious	-9.15	medium_impact	3	0.7	neutral	0.18	damaging	3.72	23.30	deleterious	0.09	0.35	NA	NA	0.68	disease	0.73	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.75	medium_impact	1.84	medium_impact	0.24	0.8	39.87	8.23	0.33	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10805	10805	T	C	MI.16404	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	46	16	W	R	Tga/Cga	-4.78	0	0	probably_damaging	1	deleterious	0.02	neutral	1.5	neutral	-2.1	deleterious	-9.86	medium_impact	3.35	0.72	neutral	0.13	damaging	3.34	22.90	deleterious	0.07	0.35	NA	NA	0.82	disease	0.76	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-0.75	medium_impact	2.19	high_impact	0.18	0.8	39.87	8.23	0.4	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10806	10806	G	C	MI.16405	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	47	16	W	S	tGa/tCa	1.68	0.78	0	probably_damaging	1	deleterious	0.04	neutral	1.55	neutral	-0.56	deleterious	-9.71	medium_impact	3.35	0.72	neutral	0.2	damaging	3.76	23.30	deleterious	0.09	0.35	NA	NA	0.71	disease	0.7	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-0.57	medium_impact	2.19	high_impact	0.28	0.8	39.87	8.23	0.41	N	0.93	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10806	10806	G	T	MI.16406	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	47	16	W	L	tGa/tTa	1.68	0.78	0	probably_damaging	1	neutral	0.55	neutral	1.74	neutral	1.29	deleterious	-9.2	medium_impact	2.15	0.73	neutral	0.32	neutral	4.01	23.60	deleterious	0.1	0.4	NA	NA	0.45	neutral	0.48	neutral	0.22	neutral	6	1	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.25	medium_impact	1	medium_impact	0.23	0.8	39.87	8.23	0.34	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10807	10807	A	T	MI.16407	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	48	16	W	C	tgA/tgT	2.37	0.8	0	probably_damaging	1	deleterious	0.01	neutral	1.51	neutral	-1.59	deleterious	-9.17	medium_impact	2.65	0.76	neutral	0.17	damaging	3.92	23.50	deleterious	0.09	0.35	NA	NA	0.73	disease	0.7	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.92	medium_impact	1.5	medium_impact	0.30	0.8	39.87	8.23	0.36	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10807	10807	A	C	MI.16408	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	48	16	W	C	tgA/tgC	2.37	0.8	0	probably_damaging	1	deleterious	0.01	neutral	1.51	neutral	-1.59	deleterious	-9.17	medium_impact	2.65	0.76	neutral	0.17	damaging	3.78	23.40	deleterious	0.09	0.35	NA	NA	0.73	disease	0.7	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.92	medium_impact	1.5	medium_impact	0.30	0.8	39.87	8.23	0.35	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10808	10808	C	T	MI.16409	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	49	17	L	F	Ctt/Ttt	0.29	0.01	0	benign	0.04	neutral	0.17	neutral	1.38	neutral	-1.64	neutral	-1.17	low_impact	1.59	0.77	neutral	0.98	neutral	2.43	19.04	deleterious	0.19	0.45	NA	NA	0.37	neutral	0.3	neutral	0.2	neutral	6	0.82	neutral	0.57	deleterious	-6	neutral	0.73	deleterious	0.58	medium_impact	-0.18	medium_impact	0.45	medium_impact	0.52	0.8	20.7	14.56	0.45	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8459	8459	A	C	MI.1641	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	94	32	N	H	Aac/Cac	-2.65	0	0	probably_damaging	1	neutral	0.54	neutral	1.5	neutral	-2.24	neutral	-1.63	neutral_impact	0.7	1	neutral	0.94	neutral	0.97	10.47	neutral	0.73321515	0.85	0.4	neutral	0.13	neutral	0.61	disease	0.07	neutral	9	0.99	deleterious	0.27	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.33	medium_impact	-0.5	medium_impact	0.49	0.85	13.24	7.92	0.36	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10808	10808	C	G	MI.16410	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	49	17	L	V	Ctt/Gtt	0.29	0.01	0	benign	0.32	neutral	0.1	neutral	1.43	neutral	-1.08	neutral	-1.59	medium_impact	2.61	0.69	neutral	0.66	neutral	3.23	22.80	deleterious	0.3	0.45	NA	NA	0.44	neutral	0.31	neutral	0.25	neutral	5	0.88	neutral	0.39	neutral	-3	neutral	0.73	deleterious	-0.41	medium_impact	-0.33	medium_impact	1.46	medium_impact	0.50	0.8	20.7	14.56	0.48	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10808	10808	C	A	MI.16411	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	49	17	L	I	Ctt/Att	0.29	0.01	0	benign	0.06	neutral	0.14	neutral	1.45	neutral	-0.89	neutral	-1	medium_impact	2.12	0.7	neutral	0.73	neutral	3.87	23.50	deleterious	0.27	0.45	NA	NA	0.46	neutral	0.26	neutral	0.27	neutral	5	0.85	neutral	0.54	deleterious	-3	neutral	0.74	deleterious	0.41	medium_impact	-0.24	medium_impact	0.97	medium_impact	0.49	0.8	20.7	14.56	0.5	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10809	10809	T	A	MI.16412	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	50	17	L	H	cTt/cAt	-3.86	0	0	benign	0.13	deleterious	0.01	neutral	1.28	deleterious	-4.2	deleterious	-3.58	medium_impact	3.15	0.64	neutral	0.51	neutral	4.15	23.80	deleterious	0.08	0.35	NA	NA	0.7	disease	0.7	disease	0.69	disease	4	0.99	deleterious	0.44	neutral	1	deleterious	0.78	deleterious	0.06	medium_impact	-0.92	medium_impact	1.99	medium_impact	0.15	0.8	20.7	14.56	0.38	N	0.76	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10809	10809	T	G	MI.16413	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	50	17	L	R	cTt/cGt	-3.86	0	0	possibly_damaging	0.87	deleterious	0.01	neutral	1.29	deleterious	-3.59	deleterious	-3.52	medium_impact	3.15	0.59	damaging	0.37	neutral	4.04	23.70	deleterious	0.05	0.35	NA	NA	0.84	disease	0.72	disease	0.78	disease	6	1	deleterious	0.07	neutral	4	deleterious	0.85	deleterious	-1.49	low_impact	-0.92	medium_impact	1.99	medium_impact	0.17	0.8	20.7	14.56	0.35	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10809	10809	T	C	MI.16414	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	50	17	L	P	cTt/cCt	-3.86	0	0	probably_damaging	0.95	deleterious	0	neutral	1.28	deleterious	-4.27	deleterious	-4.21	medium_impact	3.15	0.57	damaging	0.32	neutral	3.80	23.40	deleterious	0.06	0.35	NA	NA	0.81	disease	0.73	disease	0.75	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.84	deleterious	-1.92	low_impact	-1.48	low_impact	1.99	medium_impact	0.15	0.8	20.7	14.56	0.33	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10811	10811	T	G	MI.16415	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	52	18	S	A	Tcc/Gcc	-4.09	0	0	probably_damaging	1	neutral	0.89	neutral	1.53	neutral	-0.63	neutral	-1.73	low_impact	1.77	0.78	neutral	0.7	neutral	2.16	17.22	deleterious	0.21	0.45	NA	NA	0.31	neutral	0.25	neutral	0.2	neutral	6	1	deleterious	0.45	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.71	medium_impact	0.63	medium_impact	0.52	0.8	45.53	8.16	0.27	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10811	10811	T	C	MI.16416	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	52	18	S	P	Tcc/Ccc	-4.09	0	0	probably_damaging	1	neutral	0.32	neutral	1.45	neutral	-2.51	deleterious	-3.15	medium_impact	3.12	0.53	damaging	0.32	neutral	3.74	23.30	deleterious	0.1	0.4	NA	NA	0.86	disease	0.4	neutral	0.75	disease	5	1	deleterious	0.16	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	0.02	medium_impact	1.96	medium_impact	0.43	0.8	45.53	8.16	0.4	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10811	10811	T	A	MI.16417	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	52	18	S	T	Tcc/Acc	-4.09	0	0	probably_damaging	1	neutral	0.76	neutral	1.54	neutral	-0.44	neutral	-1.19	low_impact	1.46	0.77	neutral	0.9	neutral	1.99	16.15	deleterious	0.13	0.4	NA	NA	0.22	neutral	0.2	neutral	0.2	neutral	6	1	deleterious	0.38	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.48	medium_impact	0.32	medium_impact	0.48	0.8	45.53	8.16	0.32	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10812	10812	C	T	MI.16418	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	53	18	S	F	tCc/tTc	0.29	0	0	probably_damaging	1	neutral	0.34	neutral	1.48	neutral	-1.48	deleterious	-3.81	medium_impact	3.12	0.7	neutral	0.41	neutral	4.02	23.60	deleterious	0.07	0.35	NA	NA	0.73	disease	0.37	neutral	0.54	disease	1	1	deleterious	0.17	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.04	medium_impact	1.96	medium_impact	0.20	0.8	45.53	8.16	0.39	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10812	10812	C	G	MI.16419	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	53	18	S	C	tCc/tGc	0.29	0	0	probably_damaging	1	neutral	0.14	neutral	1.47	neutral	-1.69	deleterious	-3.09	medium_impact	2.58	0.76	neutral	0.56	neutral	3.31	22.90	deleterious	0.09	0.35	NA	NA	0.65	disease	0.3	neutral	0.47	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.24	medium_impact	1.43	medium_impact	0.44	0.8	45.53	8.16	0.43	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8459	8459	A	T	MI.1642	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	94	32	N	Y	Aac/Tac	-2.65	0	0	probably_damaging	1	neutral	1	neutral	1.49	deleterious	-3.07	deleterious	-2.81	low_impact	1.07	1	neutral	0.74	neutral	0.95	10.37	neutral	0.58788784	0.85	0.31	neutral	0.15	neutral	0.56	disease	0.07	neutral	9	0.99	deleterious	0.5	deleterious	-2	neutral	0.67	deleterious	-3.6	low_impact	1.98	high_impact	-0.18	medium_impact	0.47	0.85	13.24	7.92	0.3	N	0.11	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10812	10812	C	A	MI.16420	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	53	18	S	Y	tCc/tAc	0.29	0	0	probably_damaging	1	neutral	0.46	neutral	1.45	neutral	-2.48	deleterious	-3.83	medium_impact	3.12	0.71	neutral	0.37	neutral	3.81	23.40	deleterious	0.06	0.35	NA	NA	0.78	disease	0.58	disease	0.75	disease	5	1	deleterious	0.23	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.16	medium_impact	1.96	medium_impact	0.33	0.8	45.53	8.16	0.31	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10814	10814	A	G	MI.16421	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	55	19	K	E	Aaa/Gaa	-8.01	0	0	possibly_damaging	0.72	neutral	0.21	neutral	1.45	neutral	-1.05	neutral	-1.55	medium_impact	2.76	0.78	neutral	0.42	neutral	2.46	19.18	deleterious	0.18	0.45	NA	NA	0.77	disease	0.57	disease	0.71	disease	4	0.84	neutral	0.25	neutral	0	NA	0.79	deleterious	-1.1	low_impact	-0.12	medium_impact	1.61	medium_impact	0.46	0.8	21.35	16.46	0.37	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10814	10814	A	C	MI.16422	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	55	19	K	Q	Aaa/Caa	-8.01	0	0	possibly_damaging	0.86	neutral	0.13	neutral	1.41	neutral	-1.73	neutral	-1.52	medium_impact	2.42	0.79	neutral	0.57	neutral	2.03	16.38	deleterious	0.26	0.45	NA	NA	0.57	disease	0.41	neutral	0.5	neutral	0	0.94	neutral	0.14	neutral	0	NA	0.74	deleterious	-1.46	low_impact	-0.26	medium_impact	1.27	medium_impact	0.43	0.8	21.35	16.46	0.43	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10815	10815	A	T	MI.16423	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	56	19	K	M	aAa/aTa	-0.17	0	0	probably_damaging	0.96	deleterious	0.04	neutral	1.34	deleterious	-3.68	deleterious	-2.77	medium_impact	2.76	0.8	neutral	0.54	neutral	3.72	23.30	deleterious	0.09	0.35	NA	NA	0.57	disease	0.62	disease	0.71	disease	4	0.99	deleterious	0.04	neutral	5	deleterious	0.75	deleterious	-2.01	low_impact	-0.57	medium_impact	1.61	medium_impact	0.16	0.8	21.35	16.46	0.36	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10815	10815	A	C	MI.16424	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	56	19	K	T	aAa/aCa	-0.17	0	0	benign	0.09	neutral	0.21	neutral	1.41	neutral	-1.75	neutral	-2.16	medium_impact	2.21	0.72	neutral	0.83	neutral	2.08	16.74	deleterious	0.11	0.4	NA	NA	0.53	disease	0.53	disease	0.5	neutral	0	0.77	neutral	0.56	deleterious	-3	neutral	0.74	deleterious	0.23	medium_impact	-0.12	medium_impact	1.06	medium_impact	0.21	0.8	21.35	16.46	0.42	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10816	10816	A	T	MI.16425	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	57	19	K	N	aaA/aaT	0.06	0	0	benign	0.08	neutral	0.47	neutral	1.49	neutral	-0.72	neutral	-1.44	low_impact	1.15	0.74	neutral	0.97	neutral	1.93	15.75	deleterious	0.35	0.5	NA	NA	0.45	neutral	0.35	neutral	0.21	neutral	6	0.47	neutral	0.7	deleterious	-6	neutral	0.75	deleterious	0.28	medium_impact	0.17	medium_impact	0.01	medium_impact	0.35	0.8	21.35	16.46	0.42	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10816	10816	A	C	MI.16426	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	57	19	K	N	aaA/aaC	0.06	0	0	benign	0.08	neutral	0.47	neutral	1.49	neutral	-0.72	neutral	-1.44	low_impact	1.15	0.74	neutral	0.97	neutral	1.85	15.29	deleterious	0.35	0.5	NA	NA	0.45	neutral	0.35	neutral	0.21	neutral	6	0.47	neutral	0.7	deleterious	-6	neutral	0.75	deleterious	0.28	medium_impact	0.17	medium_impact	0.01	medium_impact	0.35	0.8	21.35	16.46	0.42	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10817	10817	A	C	MI.16427	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	58	20	K	Q	Aaa/Caa	-3.4	0	0	benign	0.41	neutral	0.54	neutral	1.5	neutral	-0.91	neutral	-0.56	neutral_impact	0.57	0.77	neutral	0.81	neutral	0.96	10.44	neutral	0.2	0.45	NA	NA	0.33	neutral	0.3	neutral	0.18	neutral	6	0.41	neutral	0.57	deleterious	-6	neutral	0.47	deleterious	-0.57	medium_impact	0.24	medium_impact	-0.56	medium_impact	0.31	0.8	12.42	14.19	0.28	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10817	10817	A	G	MI.16428	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	58	20	K	E	Aaa/Gaa	-3.4	0	0	benign	0.18	neutral	0.44	neutral	1.51	neutral	-0.45	neutral	-0.62	low_impact	1.54	0.78	neutral	0.65	neutral	0.00	2.55	deleterious	0.17	0.45	NA	NA	0.63	disease	0.53	disease	0.58	disease	2	0.47	neutral	0.63	deleterious	-6	neutral	0.34	neutral	-0.1	medium_impact	0.14	medium_impact	0.4	medium_impact	0.42	0.8	12.42	14.19	0.26	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10818	10818	A	T	MI.16429	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	59	20	K	M	aAa/aTa	-3.86	0	0	possibly_damaging	0.79	neutral	0.18	neutral	1.42	neutral	-2.89	neutral	-1.72	low_impact	0.85	0.81	neutral	0.77	neutral	2.29	18.11	deleterious	0.11	0.4	NA	NA	0.34	neutral	0.36	neutral	0.16	neutral	7	0.89	neutral	0.2	neutral	-3	neutral	0.62	deleterious	-1.26	low_impact	-0.17	medium_impact	-0.29	medium_impact	0.17	0.8	12.42	14.19	0.36	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8459	8459	A	G	MI.1643	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	94	32	N	D	Aac/Gac	-2.65	0	0	probably_damaging	0.97	neutral	0.21	neutral	2.18	neutral	2.95	deleterious	-2.58	low_impact	1.42	1	neutral	0.68	neutral	2.54	19.70	deleterious	0.84955088	0.90	0.28	neutral	0.2	neutral	0.66	disease	0.11	neutral	8	0.98	deleterious	0.12	neutral	-2	neutral	0.66	deleterious	-2.19	low_impact	-0.03	medium_impact	0.12	medium_impact	0.43	0.85	13.24	7.92	0.52	N	0.42	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10818	10818	A	C	MI.16430	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	59	20	K	T	aAa/aCa	-3.86	0	0	benign	0.01	neutral	0.5	neutral	1.48	neutral	-1.1	neutral	-0.76	low_impact	0.85	0.73	neutral	0.86	neutral	-0.25	0.86	neutral	0.11	0.4	NA	NA	0.3	neutral	0.34	neutral	0.15	neutral	7	0.49	neutral	0.75	deleterious	-6	neutral	0.12	neutral	1.16	medium_impact	0.2	medium_impact	-0.29	medium_impact	0.22	0.8	12.42	14.19	0.35	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10819	10819	A	C	MI.16431	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	60	20	K	N	aaA/aaC	-3.4	0	0.01	benign	0.01	neutral	0.6	neutral	1.53	neutral	-0.97	neutral	0.44	neutral_impact	-1.03	0.83	neutral	0.98	neutral	-0.25	0.87	neutral	0.3	0.45	NA	NA	0.31	neutral	0.32	neutral	0.15	neutral	7	0.39	neutral	0.8	deleterious	-6	neutral	0.38	neutral	1.16	medium_impact	0.3	medium_impact	-2.15	low_impact	0.46	0.8	12.42	14.19	0.26	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10819	10819	A	T	MI.16432	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	60	20	K	N	aaA/aaT	-3.4	0	0.01	benign	0.01	neutral	0.6	neutral	1.53	neutral	-0.97	neutral	0.44	neutral_impact	-1.03	0.83	neutral	0.98	neutral	-0.22	1.00	neutral	0.3	0.45	NA	NA	0.31	neutral	0.32	neutral	0.15	neutral	7	0.39	neutral	0.8	deleterious	-6	neutral	0.38	neutral	1.16	medium_impact	0.3	medium_impact	-2.15	low_impact	0.46	0.8	12.42	14.19	0.26	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10820	10820	C	A	MI.16433	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	61	21	H	N	Cac/Aac	-7.32	0	0	benign	0	neutral	0.5	neutral	1.68	neutral	1.74	neutral	1.01	neutral_impact	-1.35	0.83	neutral	0.98	neutral	0.49	7.35	deleterious	0.19	0.45	NA	NA	0.33	neutral	0.35	neutral	0.13	neutral	7	0.5	neutral	0.75	deleterious	-6	neutral	0.31	neutral	2.1	high_impact	0.2	medium_impact	-2.46	low_impact	0.63	0.8	31.15	15.96	0.31	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10820	10820	C	T	MI.16434	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	61	21	H	Y	Cac/Tac	-7.32	0	0	benign	0.36	neutral	0.23	neutral	1.56	neutral	-0.96	neutral	-1.37	low_impact	1.04	0.75	neutral	0.63	neutral	1.78	14.87	neutral	0.16	0.45	NA	NA	0.51	disease	0.48	neutral	0.46	neutral	1	0.73	neutral	0.44	neutral	-6	neutral	0.57	deleterious	-0.48	medium_impact	-0.09	medium_impact	-0.1	medium_impact	0.41	0.8	31.15	15.96	0.37	N	0.24	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10820	10820	C	G	MI.16435	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	61	21	H	D	Cac/Gac	-7.32	0	0	benign	0	neutral	0.06	neutral	1.62	neutral	0.85	neutral	-0.16	neutral_impact	0.34	0.74	neutral	0.63	neutral	1.85	15.31	deleterious	0.05	0.35	NA	NA	0.6	disease	0.62	disease	0.71	disease	4	0.94	neutral	0.53	deleterious	-6	neutral	0.45	deleterious	2.1	high_impact	-0.47	medium_impact	-0.79	medium_impact	0.56	0.8	31.15	15.96	0.38	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10821	10821	A	T	MI.16436	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	62	21	H	L	cAc/cTc	0.06	0	0	benign	0.11	neutral	0.17	neutral	1.59	neutral	0.16	neutral	-1.83	neutral_impact	0.49	0.73	neutral	0.79	neutral	1.59	13.79	neutral	0.06	0.35	NA	NA	0.57	disease	0.56	disease	0.62	disease	2	0.81	neutral	0.53	deleterious	-6	neutral	0.42	neutral	0.14	medium_impact	-0.18	medium_impact	-0.64	medium_impact	0.22	0.8	31.15	15.96	0.39	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10821	10821	A	G	MI.16437	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	62	21	H	R	cAc/cGc	0.06	0	0	benign	0.01	neutral	0.12	neutral	1.64	neutral	1.24	neutral	0.48	neutral_impact	0.14	0.83	neutral	0.93	neutral	0.65	8.48	deleterious	0.13	0.4	NA	NA	0.59	disease	0.32	neutral	0.47	neutral	1	0.88	neutral	0.56	deleterious	-6	neutral	0.20	neutral	1.16	medium_impact	-0.28	medium_impact	-0.99	medium_impact	0.33	0.8	31.15	15.96	0.35	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10821	10821	A	C	MI.16438	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	62	21	H	P	cAc/cCc	0.06	0	0	benign	0.2	neutral	0.06	neutral	1.58	neutral	-0.21	neutral	-0.85	low_impact	1.04	0.76	neutral	0.81	neutral	1.39	12.76	neutral	0.06	0.35	NA	NA	0.77	disease	0.56	disease	0.55	disease	1	0.93	neutral	0.43	neutral	-6	neutral	0.66	deleterious	-0.15	medium_impact	-0.47	medium_impact	-0.1	medium_impact	0.44	0.8	31.15	15.96	0.35	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10822	10822	C	G	MI.16439	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	63	21	H	Q	caC/caG	-0.4	0	0	benign	0.01	neutral	0.12	neutral	1.66	neutral	1.47	neutral	0.43	neutral_impact	0.69	0.8	neutral	0.85	neutral	1.45	13.07	neutral	0.13	0.4	NA	NA	0.38	neutral	0.48	neutral	0.15	neutral	7	0.88	neutral	0.56	deleterious	-6	neutral	0.38	neutral	1.16	medium_impact	-0.28	medium_impact	-0.44	medium_impact	0.65	0.8	31.15	15.96	0.39	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8460	8460	A	G	MI.1644	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	95	32	N	S	aAc/aGc	-4.04	0	0	probably_damaging	0.97	neutral	0.5	neutral	1.6	neutral	0.17	neutral	-1.61	neutral_impact	0.64	1	neutral	0.93	neutral	1.25	12.00	neutral	0.84509432	0.90	0.14	neutral	0.15	neutral	0.55	disease	0.11	neutral	8	0.97	neutral	0.27	neutral	-2	neutral	0.63	deleterious	-2.19	low_impact	0.29	medium_impact	-0.55	medium_impact	0.22	0.85	13.24	7.92	0.36	N	0.08	polymorphism	1	0.02	rs1116906	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10822	10822	C	A	MI.16440	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	63	21	H	Q	caC/caA	-0.4	0	0	benign	0.01	neutral	0.12	neutral	1.66	neutral	1.47	neutral	0.43	neutral_impact	0.69	0.8	neutral	0.85	neutral	1.87	15.41	deleterious	0.13	0.4	NA	NA	0.38	neutral	0.48	neutral	0.15	neutral	7	0.88	neutral	0.56	deleterious	-6	neutral	0.38	neutral	1.16	medium_impact	-0.28	medium_impact	-0.44	medium_impact	0.65	0.8	31.15	15.96	0.39	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10823	10823	A	C	MI.16441	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	64	22	M	L	Ata/Cta	-4.09	0	0	benign	0.01	neutral	0.63	neutral	1.69	neutral	1.25	neutral	-1.12	low_impact	0.93	0.75	neutral	0.98	neutral	1.67	14.24	neutral	0.19	0.45	NA	NA	0.31	neutral	0.4	neutral	0.15	neutral	7	0.35	neutral	0.81	deleterious	-6	neutral	0.55	deleterious	1.16	medium_impact	0.33	medium_impact	-0.21	medium_impact	0.40	0.8	30.72	22.15	0.39	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10823	10823	A	T	MI.16442	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	64	22	M	L	Ata/Tta	-4.09	0	0	benign	0.01	neutral	0.63	neutral	1.69	neutral	1.25	neutral	-1.12	low_impact	0.93	0.75	neutral	0.98	neutral	1.77	14.81	neutral	0.19	0.45	NA	NA	0.31	neutral	0.4	neutral	0.15	neutral	7	0.35	neutral	0.81	deleterious	-6	neutral	0.55	deleterious	1.16	medium_impact	0.33	medium_impact	-0.21	medium_impact	0.40	0.8	30.72	22.15	0.38	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10823	10823	A	G	MI.16443	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	64	22	M	V	Ata/Gta	-4.09	0	0	benign	0.18	neutral	0.21	neutral	1.61	neutral	0.32	neutral	-1.84	medium_impact	2.25	0.77	neutral	0.69	neutral	2.26	17.90	deleterious	0.19	0.45	NA	NA	0.38	neutral	0.53	disease	0.34	neutral	3	0.75	neutral	0.52	deleterious	-3	neutral	0.61	deleterious	-0.1	medium_impact	-0.12	medium_impact	1.1	medium_impact	0.48	0.8	30.72	22.15	0.41	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10824	10824	T	C	MI.16444	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	65	22	M	T	aTa/aCa	0.06	0	0	benign	0.02	neutral	0.19	neutral	1.59	neutral	0.15	neutral	-2.05	neutral_impact	0.55	0.71	neutral	0.97	neutral	1.59	13.82	neutral	0.11	0.4	NA	NA	0.38	neutral	0.45	neutral	0.15	neutral	7	0.8	neutral	0.59	deleterious	-6	neutral	0.71	deleterious	0.87	medium_impact	-0.15	medium_impact	-0.58	medium_impact	0.26	0.8	30.72	22.15	0.43	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10824	10824	T	A	MI.16445	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	65	22	M	K	aTa/aAa	0.06	0	0	possibly_damaging	0.46	neutral	0.24	neutral	1.59	neutral	0.12	neutral	-2.42	low_impact	1.15	0.78	neutral	0.88	neutral	2.65	20.50	deleterious	0.05	0.35	NA	NA	0.54	disease	0.63	disease	0.48	neutral	0	0.73	neutral	0.39	neutral	-3	neutral	0.75	deleterious	-0.65	medium_impact	-0.08	medium_impact	0.01	medium_impact	0.31	0.8	30.72	22.15	0.33	N	0.36	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10825	10825	A	T	MI.16446	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	66	22	M	I	atA/atT	-1.09	0	0	benign	0.18	neutral	0.34	neutral	1.61	neutral	0.38	neutral	-1.79	low_impact	1.36	0.75	neutral	0.79	neutral	3.24	22.80	deleterious	0.18	0.45	NA	NA	0.4	neutral	0.43	neutral	0.16	neutral	7	0.6	neutral	0.58	deleterious	-6	neutral	0.70	deleterious	-0.1	medium_impact	0.04	medium_impact	0.22	medium_impact	0.46	0.8	30.72	22.15	0.42	N	0.27	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10825	10825	A	C	MI.16447	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	66	22	M	I	atA/atC	-1.09	0	0	benign	0.18	neutral	0.34	neutral	1.61	neutral	0.38	neutral	-1.79	low_impact	1.36	0.75	neutral	0.79	neutral	3.19	22.70	deleterious	0.18	0.45	NA	NA	0.4	neutral	0.43	neutral	0.16	neutral	7	0.6	neutral	0.58	deleterious	-6	neutral	0.70	deleterious	-0.1	medium_impact	0.04	medium_impact	0.22	medium_impact	0.46	0.8	30.72	22.15	0.42	N	0.27	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10826	10826	A	C	MI.16448	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	67	23	I	L	Att/Ctt	-0.17	0	0	benign	0.01	neutral	1	neutral	1.79	neutral	1.48	neutral	0.07	neutral_impact	0.19	0.73	neutral	0.94	neutral	0.81	9.52	deleterious	0.19	0.45	NA	NA	0.08	neutral	0.29	neutral	0.17	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.59	deleterious	1.16	medium_impact	1.88	high_impact	-0.94	medium_impact	0.55	0.8	32.24	23.78	0.4	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10826	10826	A	T	MI.16449	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	67	23	I	F	Att/Ttt	-0.17	0	0	possibly_damaging	0.61	neutral	0.31	neutral	1.56	neutral	-0.27	neutral	-2.1	low_impact	1.7	0.76	neutral	0.67	neutral	3.46	23.00	deleterious	0.1	0.4	NA	NA	0.45	neutral	0.54	disease	0.36	neutral	3	0.71	neutral	0.35	neutral	-3	neutral	0.71	deleterious	-0.9	medium_impact	0.01	medium_impact	0.56	medium_impact	0.56	0.8	32.24	23.78	0.37	N	0.58	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8460	8460	A	C	MI.1645	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	95	32	N	T	aAc/aCc	-4.04	0	0	probably_damaging	0.98	neutral	0.53	neutral	1.52	neutral	-1.22	neutral	-1.55	neutral_impact	-0.62	0.99	neutral	0.95	neutral	1.43	12.96	neutral	0.76472473	0.85	0.15	neutral	0.13	neutral	0.53	disease	0.06	neutral	9	0.98	deleterious	0.28	neutral	-2	neutral	0.63	deleterious	-2.36	low_impact	0.32	medium_impact	-1.63	low_impact	0.54	0.85	13.24	7.92	0.39	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10826	10826	A	G	MI.16450	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	67	23	I	V	Att/Gtt	-0.17	0	0	benign	0.01	neutral	0.07	neutral	1.59	neutral	0.09	neutral	-0.56	low_impact	1.29	0.81	neutral	0.98	neutral	1.59	13.78	neutral	0.2	0.45	NA	NA	0.13	neutral	0.4	neutral	0.24	neutral	5	0.93	neutral	0.53	deleterious	-6	neutral	0.61	deleterious	1.16	medium_impact	-0.43	medium_impact	0.15	medium_impact	0.38	0.8	32.24	23.78	0.48	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	COSM1155500	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10827	10827	T	G	MI.16451	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	68	23	I	S	aTt/aGt	-3.4	0	0	possibly_damaging	0.75	neutral	0.06	neutral	1.54	neutral	-0.69	deleterious	-3.43	medium_impact	2.4	0.71	neutral	0.51	neutral	4.06	23.70	deleterious	0.06	0.35	NA	NA	0.55	disease	0.61	disease	0.72	disease	4	0.95	neutral	0.16	neutral	0	NA	0.75	deleterious	-1.17	low_impact	-0.47	medium_impact	1.25	medium_impact	0.37	0.8	32.24	23.78	0.39	N	0.79	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10827	10827	T	C	MI.16452	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	68	23	I	T	aTt/aCt	-3.4	0	0	possibly_damaging	0.48	neutral	0.07	neutral	1.57	neutral	-0.25	deleterious	-2.68	low_impact	1.7	0.77	neutral	0.97	neutral	3.20	22.70	deleterious	0.09	0.35	NA	NA	0.33	neutral	0.55	disease	0.34	neutral	3	0.92	neutral	0.3	neutral	-3	neutral	0.71	deleterious	-0.69	medium_impact	-0.43	medium_impact	0.56	medium_impact	0.27	0.8	32.24	23.78	0.43	N	0.56	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10827	10827	T	A	MI.16453	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	68	23	I	N	aTt/aAt	-3.4	0	0	probably_damaging	0.93	neutral	0.06	neutral	1.51	neutral	-1.27	deleterious	-4.16	medium_impact	2.4	0.67	neutral	0.5	neutral	4.40	24.10	deleterious	0.09	0.35	NA	NA	0.65	disease	0.64	disease	0.74	disease	5	0.98	deleterious	0.07	neutral	1	deleterious	0.77	deleterious	-1.77	low_impact	-0.47	medium_impact	1.25	medium_impact	0.30	0.8	32.24	23.78	0.38	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10828	10828	T	G	MI.16454	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	69	23	I	M	atT/atG	4.67	0.69	0	benign	0.17	neutral	0.12	neutral	1.54	neutral	-0.58	neutral	-0.65	low_impact	0.85	0.72	neutral	0.97	neutral	1.95	15.88	deleterious	0.16	0.45	NA	NA	0.2	neutral	0.39	neutral	0.19	neutral	6	0.86	neutral	0.48	deleterious	-6	neutral	0.68	deleterious	-0.07	medium_impact	-0.28	medium_impact	-0.29	medium_impact	0.52	0.8	32.24	23.78	0.51	P	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10828	10828	T	A	MI.16455	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	69	23	I	M	atT/atA	4.67	0.69	0	benign	0.17	neutral	0.12	neutral	1.54	neutral	-0.58	neutral	-0.65	low_impact	0.85	0.72	neutral	0.97	neutral	2.15	17.19	deleterious	0.16	0.45	NA	NA	0.2	neutral	0.39	neutral	0.19	neutral	6	0.86	neutral	0.48	deleterious	-6	neutral	0.68	deleterious	-0.07	medium_impact	-0.28	medium_impact	-0.29	medium_impact	0.52	0.8	32.24	23.78	0.5	P	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10829	10829	T	G	MI.16456	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	70	24	W	G	Tga/Gga	-5.7	0	0	probably_damaging	1	deleterious	0	neutral	1.26	deleterious	-3.71	deleterious	-9.83	medium_impact	3.44	0.56	damaging	0.1	damaging	3.63	23.20	deleterious	0.09	0.35	NA	NA	0.8	disease	0.78	disease	0.76	disease	5	1	deleterious	0	deleterious	5	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.33	0.8	47.28	9.14	0.41	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10829	10829	T	C	MI.16457	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	70	24	W	R	Tga/Cga	-5.7	0	0	probably_damaging	1	deleterious	0.02	neutral	1.27	deleterious	-3.21	deleterious	-10.58	medium_impact	3.1	0.57	damaging	0.07	damaging	3.32	22.90	deleterious	0.05	0.35	NA	NA	0.85	disease	0.82	disease	0.82	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.88	deleterious	-3.54	low_impact	-0.75	medium_impact	1.94	medium_impact	0.29	0.8	47.28	9.14	0.4	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10830	10830	G	C	MI.16458	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	71	24	W	S	tGa/tCa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	1.3	neutral	-2.48	deleterious	-10.57	medium_impact	3.1	0.53	damaging	0.09	damaging	3.71	23.30	deleterious	0.09	0.35	NA	NA	0.84	disease	0.75	disease	0.79	disease	6	1	deleterious	0	neutral	5	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	1.94	medium_impact	0.29	0.8	47.28	9.14	0.51	P	0.93	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10830	10830	G	T	MI.16459	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	71	24	W	L	tGa/tTa	7.44	1	0	probably_damaging	1	deleterious	0.01	neutral	1.36	neutral	-1.55	deleterious	-9.83	medium_impact	3.44	0.54	damaging	0.07	damaging	3.97	23.60	deleterious	0.11	0.4	NA	NA	0.76	disease	0.73	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.92	medium_impact	2.28	high_impact	0.20	0.8	47.28	9.14	0.56	P	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8460	8460	A	T	MI.1646	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	95	32	N	I	aAc/aTc	-4.04	0	0	probably_damaging	1	neutral	0.45	neutral	1.48	deleterious	-4.02	deleterious	-3.44	neutral_impact	-0.18	0.99	neutral	0.91	neutral	2.08	16.71	deleterious	0.56070775	0.85	0.32	neutral	0.24	neutral	0.56	disease	0.1	neutral	8	0.99	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.24	medium_impact	-1.25	low_impact	0.34	0.85	13.24	7.92	0.44	N	0.37	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10831	10831	A	C	MI.16460	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	72	24	W	C	tgA/tgC	6.06	1	0	probably_damaging	1	deleterious	0	neutral	1.25	deleterious	-4.32	deleterious	-9.83	medium_impact	3.44	0.53	damaging	0.05	damaging	3.74	23.30	deleterious	0.09	0.4	NA	NA	0.83	disease	0.77	disease	0.78	disease	6	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.35	0.8	47.28	9.14	0.54	P	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10831	10831	A	T	MI.16461	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	72	24	W	C	tgA/tgT	6.06	1	0	probably_damaging	1	deleterious	0	neutral	1.25	deleterious	-4.32	deleterious	-9.83	medium_impact	3.44	0.53	damaging	0.05	damaging	3.88	23.50	deleterious	0.09	0.4	NA	NA	0.83	disease	0.77	disease	0.78	disease	6	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.35	0.8	47.28	9.14	0.55	P	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10832	10832	A	T	MI.16462	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	73	25	I	F	Atc/Ttc	2.37	0.98	0	probably_damaging	0.98	neutral	0.72	neutral	1.52	neutral	-1.29	neutral	-2.17	medium_impact	2.93	0.74	neutral	0.53	neutral	2.38	18.71	deleterious	0.1	0.4	NA	NA	0.45	neutral	0.4	neutral	0.19	neutral	6	0.97	neutral	0.37	neutral	1	deleterious	0.72	deleterious	-2.31	low_impact	0.43	medium_impact	1.77	medium_impact	0.70	0.85	16.56	18.19	0.49	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10832	10832	A	G	MI.16463	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	73	25	I	V	Atc/Gtc	2.37	0.98	0	possibly_damaging	0.73	neutral	0.53	neutral	1.57	neutral	0.03	neutral	-0.23	medium_impact	2.58	0.81	neutral	0.88	neutral	1.63	13.99	neutral	0.26	0.45	NA	NA	0.16	neutral	0.37	neutral	0.23	neutral	5	0.69	neutral	0.4	neutral	0	NA	0.63	deleterious	-1.12	low_impact	0.23	medium_impact	1.43	medium_impact	0.51	0.8	16.56	18.19	0.48	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10832	10832	A	C	MI.16464	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	73	25	I	L	Atc/Ctc	2.37	0.98	0	possibly_damaging	0.73	neutral	0.7	neutral	1.6	neutral	0.3	neutral	-0.91	medium_impact	2.12	0.75	neutral	0.7	neutral	2.36	18.55	deleterious	0.16	0.45	NA	NA	0.27	neutral	0.24	neutral	0.17	neutral	7	0.67	neutral	0.49	deleterious	0	NA	0.64	deleterious	-1.12	low_impact	0.41	medium_impact	0.97	medium_impact	0.61	0.8	16.56	18.19	0.52	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10833	10833	T	A	MI.16465	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	74	25	I	N	aTc/aAc	0.06	0.4	0	probably_damaging	0.97	neutral	0.34	neutral	1.56	neutral	-2.26	deleterious	-3.19	low_impact	1.89	0.75	neutral	0.61	neutral	4.26	23.90	deleterious	0.13	0.4	NA	NA	0.56	disease	0.42	neutral	0.51	disease	0	0.97	neutral	0.19	neutral	-2	neutral	0.74	deleterious	-2.14	low_impact	0.04	medium_impact	0.74	medium_impact	0.36	0.8	16.56	18.19	0.34	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10833	10833	T	G	MI.16466	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	74	25	I	S	aTc/aGc	0.06	0.4	0	possibly_damaging	0.88	neutral	0.49	neutral	1.64	neutral	-1.16	neutral	-2.37	low_impact	1.58	0.73	neutral	0.68	neutral	2.74	21.10	deleterious	0.07	0.35	NA	NA	0.35	neutral	0.31	neutral	0.16	neutral	7	0.87	neutral	0.31	neutral	-3	neutral	0.71	deleterious	-1.53	low_impact	0.19	medium_impact	0.44	medium_impact	0.31	0.8	16.56	18.19	0.35	N	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10833	10833	T	C	MI.16467	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	74	25	I	T	aTc/aCc	0.06	0.4	0	benign	0.26	neutral	0.6	neutral	1.64	neutral	-0.92	neutral	-1.36	low_impact	1.22	0.74	neutral	0.97	neutral	1.10	11.22	neutral	0.09	0.35	NA	NA	0.11	neutral	0.26	neutral	0.21	neutral	6	0.29	neutral	0.67	deleterious	-6	neutral	0.69	deleterious	-0.29	medium_impact	0.3	medium_impact	0.08	medium_impact	0.44	0.8	16.56	18.19	0.36	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10834	10834	C	A	MI.16468	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	75	25	I	M	atC/atA	2.14	0.4	0	probably_damaging	0.98	neutral	0.25	neutral	1.54	neutral	-1.51	neutral	-1.19	medium_impact	2.24	0.77	neutral	0.74	neutral	2.47	19.26	deleterious	0.18	0.45	NA	NA	0.2	neutral	0.31	neutral	0.2	neutral	6	0.99	deleterious	0.14	neutral	1	deleterious	0.70	deleterious	-2.31	low_impact	-0.07	medium_impact	1.09	medium_impact	0.73	0.85	16.56	18.19	0.42	N	0.64	polymorphism	1	0.03	rs386829113	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	10834	10834	C	G	MI.16469	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	75	25	I	M	atC/atG	2.14	0.4	0	probably_damaging	0.98	neutral	0.25	neutral	1.54	neutral	-1.51	neutral	-1.19	medium_impact	2.24	0.77	neutral	0.74	neutral	2.01	16.28	deleterious	0.18	0.45	NA	NA	0.2	neutral	0.31	neutral	0.2	neutral	6	0.99	deleterious	0.14	neutral	1	deleterious	0.70	deleterious	-2.31	low_impact	-0.07	medium_impact	1.09	medium_impact	0.73	0.85	16.56	18.19	0.42	N	0.64	polymorphism	1	0.03	rs386829113	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8461	8461	C	G	MI.1647	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	96	32	N	K	aaC/aaG	-3.8	0	0	probably_damaging	0.98	neutral	0.37	neutral	1.55	neutral	-0.62	neutral	-2.33	low_impact	0.87	1	neutral	0.77	neutral	2.44	19.10	deleterious	0.86761339	0.90	0.19	neutral	0.25	neutral	0.65	disease	0.09	neutral	8	0.98	deleterious	0.2	neutral	-2	neutral	0.68	deleterious	-2.36	low_impact	0.16	medium_impact	-0.35	medium_impact	0.62	0.85	13.24	7.92	0.45	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10835	10835	A	G	MI.16470	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	76	26	N	D	Aac/Gac	-9.39	0	0	probably_damaging	1	neutral	0.21	neutral	1.53	neutral	-1.31	deleterious	-2.84	medium_impact	2.62	0.77	neutral	0.11	damaging	3.58	23.20	deleterious	0.28	0.45	NA	NA	0.57	disease	0.58	disease	0.7	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.12	medium_impact	1.47	medium_impact	0.61	0.8	45.1	8.46	0.23	N	0.96	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10835	10835	A	C	MI.16471	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	76	26	N	H	Aac/Cac	-9.39	0	0	probably_damaging	1	neutral	0.55	neutral	1.53	neutral	-1.2	deleterious	-2.96	low_impact	1.93	0.8	neutral	0.23	damaging	1.73	14.56	neutral	0.21	0.45	NA	NA	0.5	disease	0.53	disease	0.48	neutral	0	1	deleterious	0.28	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	0.25	medium_impact	0.78	medium_impact	0.52	0.8	45.1	8.46	0.21	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10835	10835	A	T	MI.16472	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	76	26	N	Y	Aac/Tac	-9.39	0	0	probably_damaging	1	neutral	1	neutral	1.54	neutral	-1.04	deleterious	-4.5	medium_impact	2.97	0.78	neutral	0.11	damaging	2.33	18.33	deleterious	0.1	0.4	NA	NA	0.69	disease	0.54	disease	0.62	disease	2	1	deleterious	0.5	deleterious	1	deleterious	0.79	deleterious	-3.54	low_impact	1.88	high_impact	1.81	medium_impact	0.43	0.8	45.1	8.46	0.16	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10836	10836	A	T	MI.16473	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	77	26	N	I	aAc/aTc	0.75	0	0	probably_damaging	1	neutral	0.41	neutral	1.63	neutral	0.56	deleterious	-4.79	medium_impact	2.27	0.76	neutral	0.27	damaging	2.67	20.60	deleterious	0.1	0.4	NA	NA	0.69	disease	0.4	neutral	0.53	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.11	medium_impact	1.12	medium_impact	0.32	0.8	45.1	8.46	0.28	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10836	10836	A	G	MI.16474	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	77	26	N	S	aAc/aGc	0.75	0	0	probably_damaging	1	neutral	0.47	neutral	1.62	neutral	0.51	neutral	-2.32	low_impact	1.77	0.77	neutral	0.35	neutral	1.39	12.74	neutral	0.32	0.5	NA	NA	0.31	neutral	0.39	neutral	0.17	neutral	7	1	deleterious	0.24	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	0.17	medium_impact	0.63	medium_impact	0.39	0.8	45.1	8.46	0.3	N	0.85	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10836	10836	A	C	MI.16475	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	77	26	N	T	aAc/aCc	0.75	0	0	probably_damaging	1	neutral	0.51	neutral	1.65	neutral	0.81	neutral	-2.36	low_impact	0.92	0.76	neutral	0.41	neutral	1.09	11.15	neutral	0.17	0.45	NA	NA	0.17	neutral	0.29	neutral	0.18	neutral	6	1	deleterious	0.26	neutral	-2	neutral	0.70	deleterious	-3.54	low_impact	0.21	medium_impact	-0.22	medium_impact	0.55	0.8	45.1	8.46	0.3	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10837	10837	C	A	MI.16476	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	78	26	N	K	aaC/aaA	3.06	0.02	0	probably_damaging	1	neutral	0.3	neutral	1.56	neutral	-0.42	deleterious	-3.29	medium_impact	2.97	0.76	neutral	0.1	damaging	4.07	23.70	deleterious	0.25	0.45	NA	NA	0.61	disease	0.59	disease	0.72	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0	medium_impact	1.81	medium_impact	0.65	0.8	45.1	8.46	0.36	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10837	10837	C	G	MI.16477	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	78	26	N	K	aaC/aaG	3.06	0.02	0	probably_damaging	1	neutral	0.3	neutral	1.56	neutral	-0.42	deleterious	-3.29	medium_impact	2.97	0.76	neutral	0.1	damaging	3.62	23.20	deleterious	0.25	0.45	NA	NA	0.61	disease	0.59	disease	0.72	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0	medium_impact	1.81	medium_impact	0.65	0.8	45.1	8.46	0.36	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10838	10838	A	G	MI.16478	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	79	27	T	A	Aca/Gca	-6.16	0	0	benign	0.36	neutral	0.47	neutral	1.53	neutral	-0.59	neutral	-1.33	low_impact	1.68	0.76	neutral	0.99	neutral	1.78	14.90	neutral	0.16	0.45	NA	NA	0.25	neutral	0.47	neutral	0.18	neutral	6	0.45	neutral	0.56	deleterious	-6	neutral	0.68	deleterious	-0.48	medium_impact	0.17	medium_impact	0.54	medium_impact	0.47	0.8	30.72	21.73	0.38	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10838	10838	A	T	MI.16479	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	79	27	T	S	Aca/Tca	-6.16	0	0	possibly_damaging	0.52	neutral	0.67	neutral	1.59	neutral	0.01	neutral	-0.68	low_impact	1.17	0.77	neutral	0.99	neutral	1.06	11.02	neutral	0.19	0.45	NA	NA	0.21	neutral	0.31	neutral	0.18	neutral	6	0.43	neutral	0.58	deleterious	-3	neutral	0.70	deleterious	-0.75	medium_impact	0.37	medium_impact	0.03	medium_impact	0.66	0.8	30.72	21.73	0.32	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8461	8461	C	A	MI.1648	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	96	32	N	K	aaC/aaA	-3.8	0	0	probably_damaging	0.98	neutral	0.37	neutral	1.55	neutral	-0.62	neutral	-2.33	low_impact	0.87	1	neutral	0.77	neutral	2.87	21.70	deleterious	0.86761339	0.90	0.19	neutral	0.25	neutral	0.65	disease	0.09	neutral	8	0.98	deleterious	0.2	neutral	-2	neutral	0.68	deleterious	-2.36	low_impact	0.16	medium_impact	-0.35	medium_impact	0.62	0.85	13.24	7.92	0.45	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10838	10838	A	C	MI.16480	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	79	27	T	P	Aca/Cca	-6.16	0	0	possibly_damaging	0.86	neutral	0.19	neutral	1.45	neutral	-2.42	neutral	-1.55	medium_impact	2.28	0.77	neutral	0.96	neutral	1.96	15.97	deleterious	0.08	0.35	NA	NA	0.68	disease	0.54	disease	0.52	disease	0	0.92	neutral	0.17	neutral	0	NA	0.78	deleterious	-1.46	low_impact	-0.15	medium_impact	1.13	medium_impact	0.44	0.8	30.72	21.73	0.4	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10839	10839	C	A	MI.16481	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	80	27	T	K	aCa/aAa	-3.4	0	0	possibly_damaging	0.64	neutral	0.33	neutral	1.48	neutral	-1.35	neutral	-2.07	medium_impact	2.83	0.73	neutral	0.41	neutral	4.21	23.90	deleterious	0.08	0.35	NA	NA	0.69	disease	0.6	disease	0.72	disease	4	0.71	neutral	0.35	neutral	0	NA	0.78	deleterious	-0.95	medium_impact	0.03	medium_impact	1.67	medium_impact	0.44	0.8	30.72	21.73	0.35	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10839	10839	C	T	MI.16482	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	80	27	T	M	aCa/aTa	-3.4	0	0	benign	0.12	neutral	0.33	neutral	1.47	neutral	-1.55	neutral	-1.67	medium_impact	2.13	0.72	neutral	0.78	neutral	2.68	20.70	deleterious	0.1	0.4	NA	NA	0.4	neutral	0.41	neutral	0.18	neutral	6	0.62	neutral	0.61	deleterious	-3	neutral	0.70	deleterious	0.1	medium_impact	0.03	medium_impact	0.98	medium_impact	0.55	0.8	30.72	21.73	0.44	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10841	10841	A	T	MI.16483	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	82	28	T	S	Acc/Tcc	-11.93	0	0	possibly_damaging	0.8	neutral	0.41	neutral	1.42	neutral	-1.71	neutral	-1.6	medium_impact	2.63	0.78	neutral	0.83	neutral	2.45	19.12	deleterious	0.21	0.45	NA	NA	0.46	neutral	0.42	neutral	0.25	neutral	5	0.81	neutral	0.31	neutral	0	NA	0.76	deleterious	-1.28	low_impact	0.11	medium_impact	1.48	medium_impact	0.58	0.8	17.43	15.51	0.42	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10841	10841	A	C	MI.16484	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	82	28	T	P	Acc/Ccc	-11.93	0	0	benign	0.12	neutral	0.21	neutral	1.36	deleterious	-3.67	deleterious	-3.43	medium_impact	3.18	0.66	neutral	0.31	neutral	3.71	23.30	deleterious	0.1	0.4	NA	NA	0.79	disease	0.68	disease	0.72	disease	4	0.76	neutral	0.55	deleterious	-3	neutral	0.83	deleterious	0.1	medium_impact	-0.12	medium_impact	2.02	high_impact	0.39	0.8	17.43	15.51	0.36	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10841	10841	A	G	MI.16485	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	82	28	T	A	Acc/Gcc	-11.93	0	0	possibly_damaging	0.64	neutral	0.51	neutral	1.45	neutral	-1.29	neutral	-2.42	medium_impact	2.38	0.77	neutral	0.6	neutral	3.69	23.30	deleterious	0.2	0.45	NA	NA	0.41	neutral	0.56	disease	0.38	neutral	2	0.62	neutral	0.44	neutral	0	NA	0.73	deleterious	-0.95	medium_impact	0.21	medium_impact	1.23	medium_impact	0.46	0.8	17.43	15.51	0.33	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10842	10842	C	T	MI.16486	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	83	28	T	I	aCc/aTc	1.21	0	0	possibly_damaging	0.83	neutral	0.46	neutral	1.53	neutral	-0.42	deleterious	-2.98	medium_impact	2.38	0.71	neutral	0.62	neutral	2.54	19.74	deleterious	0.12	0.4	NA	NA	0.68	disease	0.45	neutral	0.52	disease	0	0.82	neutral	0.32	neutral	0	NA	0.77	deleterious	-1.37	low_impact	0.16	medium_impact	1.23	medium_impact	0.68	0.85	17.43	15.51	0.35	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10842	10842	C	G	MI.16487	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	83	28	T	S	aCc/aGc	1.21	0	0	possibly_damaging	0.8	neutral	0.41	neutral	1.42	neutral	-1.71	neutral	-1.6	medium_impact	2.63	0.78	neutral	0.83	neutral	2.12	16.97	deleterious	0.21	0.45	NA	NA	0.46	neutral	0.42	neutral	0.25	neutral	5	0.81	neutral	0.31	neutral	0	NA	0.76	deleterious	-1.28	low_impact	0.11	medium_impact	1.48	medium_impact	0.58	0.8	17.43	15.51	0.37	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10842	10842	C	A	MI.16488	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	83	28	T	N	aCc/aAc	1.21	0	0	probably_damaging	0.96	neutral	0.31	neutral	1.37	deleterious	-3.2	deleterious	-2.65	medium_impact	2.84	0.71	neutral	0.41	neutral	3.53	23.10	deleterious	0.2	0.45	NA	NA	0.62	disease	0.56	disease	0.66	disease	3	0.96	neutral	0.18	neutral	1	deleterious	0.76	deleterious	-2.01	low_impact	0.01	medium_impact	1.68	medium_impact	0.46	0.8	17.43	15.51	0.37	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10844	10844	A	G	MI.16489	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	85	29	T	A	Acc/Gcc	-5.24	0	0	benign	0.36	neutral	0.73	neutral	1.6	neutral	0.17	neutral	-0.24	neutral_impact	0.29	0.71	neutral	1	neutral	1.47	13.17	neutral	0.18	0.45	NA	NA	0.09	neutral	0.32	neutral	0.21	neutral	6	0.26	neutral	0.69	deleterious	-6	neutral	0.64	deleterious	-0.48	medium_impact	0.44	medium_impact	-0.84	medium_impact	0.39	0.8	11.76	11.57	0.34	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8462	8462	T	C	MI.1649	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	97	33	Y	H	Tac/Cac	-8.2	0	0	probably_damaging	0.99	neutral	0.54	neutral	1.56	deleterious	-3.82	deleterious	-3.59	low_impact	1.42	1	neutral	0.92	neutral	2.49	19.39	deleterious	0.57564883	0.85	0.65	disease	0.35	neutral	0.63	disease	0.24	neutral	5	0.99	deleterious	0.28	neutral	-2	neutral	0.81	deleterious	-2.65	low_impact	0.33	medium_impact	0.12	medium_impact	0.24	0.85	NA	NA	0.41	N	0.23	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10844	10844	A	T	MI.16490	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	85	29	T	S	Acc/Tcc	-5.24	0	0	benign	0.04	neutral	0.54	neutral	1.57	neutral	-0.21	neutral	-0.35	neutral_impact	0.64	0.75	neutral	0.98	neutral	1.46	13.08	neutral	0.25	0.45	NA	NA	0.13	neutral	0.33	neutral	0.21	neutral	6	0.41	neutral	0.75	deleterious	-6	neutral	0.66	deleterious	0.58	medium_impact	0.24	medium_impact	-0.49	medium_impact	0.52	0.8	11.76	11.57	0.36	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10844	10844	A	C	MI.16491	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	85	29	T	P	Acc/Ccc	-5.24	0	0	possibly_damaging	0.75	neutral	0.19	neutral	1.49	neutral	-2.35	neutral	-1.85	medium_impact	2.43	0.65	neutral	0.38	neutral	3.65	23.20	deleterious	0.07	0.35	NA	NA	0.64	disease	0.6	disease	0.68	disease	4	0.87	neutral	0.22	neutral	0	NA	0.76	deleterious	-1.17	low_impact	-0.15	medium_impact	1.28	medium_impact	0.36	0.8	11.76	11.57	0.35	N	0.68	polymorphism	1	0.02	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10845	10845	C	T	MI.16492	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	86	29	T	I	aCc/aTc	-7.32	0	0	benign	0.04	neutral	0.55	neutral	1.64	neutral	0.6	neutral	-0.13	low_impact	1.1	0.74	neutral	0.99	neutral	2.16	17.24	deleterious	0.13	0.4	NA	NA	0.37	neutral	0.37	neutral	0.14	neutral	7	0.4	neutral	0.76	deleterious	-6	neutral	0.69	deleterious	0.58	medium_impact	0.25	medium_impact	-0.04	medium_impact	0.55	0.8	11.76	11.57	0.36	N	0.45	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10845	10845	C	A	MI.16493	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	86	29	T	N	aCc/aAc	-7.32	0	0	possibly_damaging	0.61	neutral	0.3	neutral	1.5	neutral	-1.98	neutral	-1.59	medium_impact	2.43	0.8	neutral	0.58	neutral	2.33	18.38	deleterious	0.25	0.45	NA	NA	0.36	neutral	0.45	neutral	0.16	neutral	7	0.72	neutral	0.35	neutral	0	NA	0.68	deleterious	-0.9	medium_impact	0	medium_impact	1.28	medium_impact	0.53	0.8	11.76	11.57	0.39	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10845	10845	C	G	MI.16494	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	86	29	T	S	aCc/aGc	-7.32	0	0	benign	0.04	neutral	0.54	neutral	1.57	neutral	-0.21	neutral	-0.35	neutral_impact	0.64	0.75	neutral	0.98	neutral	1.19	11.70	neutral	0.25	0.45	NA	NA	0.13	neutral	0.33	neutral	0.21	neutral	6	0.41	neutral	0.75	deleterious	-6	neutral	0.66	deleterious	0.58	medium_impact	0.24	medium_impact	-0.49	medium_impact	0.52	0.8	11.76	11.57	0.35	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10847	10847	C	G	MI.16495	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	88	30	H	D	Cac/Gac	-20	0	0	possibly_damaging	0.76	neutral	0.16	neutral	1.54	neutral	-1.91	deleterious	-4.45	medium_impact	2.68	0.72	neutral	0.4	neutral	3.62	23.20	deleterious	0.07	0.35	NA	NA	0.69	disease	0.7	disease	0.76	disease	5	0.89	neutral	0.2	neutral	0	NA	0.78	deleterious	-1.19	low_impact	-0.2	medium_impact	1.53	medium_impact	0.51	0.8	15.69	16.24	0.37	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10847	10847	C	T	MI.16496	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	88	30	H	Y	Cac/Tac	-20	0	0	benign	0.04	neutral	1	neutral	1.65	neutral	1.02	neutral	-0.76	neutral_impact	0.06	0.83	neutral	0.98	neutral	1.68	14.31	neutral	0.16	0.45	NA	NA	0.3	neutral	0.45	neutral	0.17	neutral	7	0.04	neutral	0.98	deleterious	-6	neutral	0.72	deleterious	0.58	medium_impact	1.88	high_impact	-1.07	low_impact	0.39	0.8	15.69	16.24	0.28	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10847	10847	C	A	MI.16497	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	88	30	H	N	Cac/Aac	-20	0	0	possibly_damaging	0.56	neutral	0.38	neutral	1.58	neutral	-0.16	deleterious	-3.25	low_impact	1.88	0.76	neutral	0.7	neutral	2.51	19.52	deleterious	0.33	0.5	NA	NA	0.4	neutral	0.52	disease	0.33	neutral	3	0.63	neutral	0.41	neutral	-3	neutral	0.72	deleterious	-0.82	medium_impact	0.08	medium_impact	0.73	medium_impact	0.42	0.8	15.69	16.24	0.39	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10848	10848	A	T	MI.16498	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	89	30	H	L	cAc/cTc	-4.78	0	0	possibly_damaging	0.56	neutral	0.62	neutral	1.7	neutral	1.57	deleterious	-4.84	low_impact	1.79	0.73	neutral	0.64	neutral	3.70	23.30	deleterious	0.1	0.4	NA	NA	0.73	disease	0.53	disease	0.54	disease	1	0.49	neutral	0.53	deleterious	-3	neutral	0.77	deleterious	-0.82	medium_impact	0.32	medium_impact	0.65	medium_impact	0.27	0.8	15.69	16.24	0.31	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10848	10848	A	C	MI.16499	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	89	30	H	P	cAc/cCc	-4.78	0	0	probably_damaging	0.93	neutral	0.16	neutral	1.54	neutral	-1.82	deleterious	-5	medium_impact	2.68	0.64	neutral	0.33	neutral	3.03	22.30	deleterious	0.08	0.35	NA	NA	0.85	disease	0.72	disease	0.79	disease	6	0.96	neutral	0.12	neutral	1	deleterious	0.83	deleterious	-1.77	low_impact	-0.2	medium_impact	1.53	medium_impact	0.31	0.8	15.69	16.24	0.3	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8603	8603	T	C	MI.165	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	77	26	F	S	tTt/tCt	-0.33	0	0	benign	0.43	deleterious	0.03	neutral	4.33	neutral	-0.63	deleterious	-4.76	low_impact	1.58	0.93	neutral	0.64	neutral	2.42	18.98	deleterious	0.39	0.65	0.56	disease	0.54	disease	0.57	disease	0.65	disease	3	0.97	neutral	0.3	neutral	-2	neutral	0.36	neutral	-0.64	medium_impact	-0.56	medium_impact	0.26	medium_impact	0.37	0.9	15.49	8.03	0.43	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8462	8462	T	G	MI.1650	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	97	33	Y	D	Tac/Gac	-8.2	0	0	probably_damaging	1	neutral	0.23	neutral	1.55	deleterious	-4.75	deleterious	-7.78	medium_impact	2.69	0.99	neutral	0.33	neutral	3.93	23.50	deleterious	0.38394872	0.85	0.89	disease	0.43	neutral	0.75	disease	0.34	neutral	3	1	deleterious	0.12	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.01	medium_impact	1.21	medium_impact	0.30	0.85	NA	NA	0.49	N	0.74	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10848	10848	A	G	MI.16500	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	89	30	H	R	cAc/cGc	-4.78	0	0	possibly_damaging	0.81	neutral	0.28	neutral	1.55	neutral	-1.07	deleterious	-3.81	medium_impact	2.68	0.78	neutral	0.41	neutral	2.79	21.30	deleterious	0.15	0.45	NA	NA	0.72	disease	0.64	disease	0.73	disease	5	0.85	neutral	0.24	neutral	0	NA	0.79	deleterious	-1.31	low_impact	-0.03	medium_impact	1.53	medium_impact	0.31	0.8	15.69	16.24	0.3	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10849	10849	C	G	MI.16501	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	90	30	H	Q	caC/caG	5.36	0.53	0	possibly_damaging	0.87	neutral	0.41	neutral	1.6	neutral	0.27	deleterious	-3.25	low_impact	1.4	0.76	neutral	0.78	neutral	1.61	13.90	neutral	0.21	0.45	NA	NA	0.33	neutral	0.49	neutral	0.17	neutral	7	0.87	neutral	0.27	neutral	-3	neutral	0.71	deleterious	-1.49	low_impact	0.11	medium_impact	0.26	medium_impact	0.39	0.8	15.69	16.24	0.44	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10849	10849	C	A	MI.16502	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	90	30	H	Q	caC/caA	5.36	0.53	0	possibly_damaging	0.87	neutral	0.41	neutral	1.6	neutral	0.27	deleterious	-3.25	low_impact	1.4	0.76	neutral	0.78	neutral	1.97	16.05	deleterious	0.21	0.45	NA	NA	0.33	neutral	0.49	neutral	0.17	neutral	7	0.87	neutral	0.27	neutral	-3	neutral	0.71	deleterious	-1.49	low_impact	0.11	medium_impact	0.26	medium_impact	0.39	0.8	15.69	16.24	0.44	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10850	10850	A	G	MI.16503	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	91	31	S	G	Agc/Ggc	-8.01	0	0	benign	0.08	neutral	0.33	neutral	1.32	neutral	-2.8	deleterious	-2.92	low_impact	1.75	0.81	neutral	0.91	neutral	2.02	16.35	deleterious	0.19	0.45	NA	NA	0.54	disease	0.51	disease	0.44	neutral	1	0.63	neutral	0.63	deleterious	-6	neutral	0.74	deleterious	0.28	medium_impact	0.03	medium_impact	0.61	medium_impact	0.40	0.8	47.71	9.69	0.35	N	0.27	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10850	10850	A	C	MI.16504	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	91	31	S	R	Agc/Cgc	-8.01	0	0	probably_damaging	0.97	neutral	0.29	neutral	1.32	neutral	-2.61	deleterious	-3.74	medium_impact	3.35	0.64	neutral	0.4	neutral	3.44	23.00	deleterious	0.11	0.4	NA	NA	0.84	disease	0.76	disease	0.79	disease	6	0.97	neutral	0.16	neutral	1	deleterious	0.85	deleterious	-2.14	low_impact	-0.02	medium_impact	2.19	high_impact	0.41	0.8	47.71	9.69	0.42	N	0.93	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10850	10850	A	T	MI.16505	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	91	31	S	C	Agc/Tgc	-8.01	0	0	probably_damaging	0.98	neutral	0.15	neutral	1.28	deleterious	-4.65	deleterious	-3.73	medium_impact	3.35	0.77	neutral	0.39	neutral	3.02	22.30	deleterious	0.12	0.4	NA	NA	0.71	disease	0.6	disease	0.66	disease	3	0.99	deleterious	0.09	neutral	1	deleterious	0.78	deleterious	-2.31	low_impact	-0.22	medium_impact	2.19	high_impact	0.28	0.8	47.71	9.69	0.37	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10851	10851	G	T	MI.16506	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	92	31	S	I	aGc/aTc	4.67	1	0	probably_damaging	0.98	neutral	0.38	neutral	1.31	neutral	-2.88	deleterious	-4.49	medium_impact	2.8	0.67	neutral	0.52	neutral	3.87	23.50	deleterious	0.11	0.4	NA	NA	0.86	disease	0.66	disease	0.7	disease	4	0.98	neutral	0.2	neutral	1	deleterious	0.83	deleterious	-2.31	low_impact	0.08	medium_impact	1.64	medium_impact	0.25	0.8	47.71	9.69	0.53	P	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10851	10851	G	C	MI.16507	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	92	31	S	T	aGc/aCc	4.67	1	0	possibly_damaging	0.85	neutral	0.39	neutral	1.37	neutral	-1.72	neutral	-2.25	medium_impact	2.8	0.74	neutral	0.62	neutral	3.14	22.60	deleterious	0.21	0.45	NA	NA	0.51	disease	0.47	neutral	0.43	neutral	1	0.85	neutral	0.27	neutral	0	NA	0.75	deleterious	-1.43	low_impact	0.09	medium_impact	1.64	medium_impact	0.49	0.8	47.71	9.69	0.63	P	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10851	10851	G	A	MI.16508	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	92	31	S	N	aGc/aAc	4.67	1	0	probably_damaging	0.91	neutral	0.34	neutral	1.33	neutral	-2.47	neutral	-2.25	medium_impact	3.35	0.68	neutral	0.45	neutral	3.34	22.90	deleterious	0.42	0.55	NA	NA	0.61	disease	0.66	disease	0.6	disease	2	0.92	neutral	0.22	neutral	1	deleterious	0.77	deleterious	-1.66	low_impact	0.04	medium_impact	2.19	high_impact	0.44	0.8	47.71	9.69	0.62	P	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10853	10853	C	G	MI.16509	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	94	32	L	V	Cta/Gta	-0.4	0	0	possibly_damaging	0.9	neutral	0.07	neutral	1.46	neutral	-0.91	neutral	-1.78	medium_impact	3.23	0.63	neutral	0.17	damaging	3.19	22.70	deleterious	0.44	0.55	NA	NA	0.44	neutral	0.6	disease	0.42	neutral	2	0.97	neutral	0.09	neutral	0	NA	0.74	deleterious	-1.61	low_impact	-0.43	medium_impact	2.07	high_impact	0.24	0.8	18.95	18.03	0.43	N	0.40	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8462	8462	T	A	MI.1651	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	97	33	Y	N	Tac/Aac	-8.2	0	0	probably_damaging	1	neutral	0.34	neutral	1.56	deleterious	-4.01	deleterious	-7	low_impact	1.6	0.99	neutral	0.52	neutral	4.18	23.80	deleterious	0.48392560	0.85	0.8	disease	0.37	neutral	0.71	disease	0.28	neutral	4	1	deleterious	0.17	neutral	-2	neutral	0.83	deleterious	-3.6	low_impact	0.13	medium_impact	0.27	medium_impact	0.25	0.85	NA	NA	0.46	N	0.71	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10853	10853	C	A	MI.16510	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	94	32	L	M	Cta/Ata	-0.4	0	0	probably_damaging	0.99	neutral	0.25	neutral	1.44	neutral	-1.17	neutral	-0.98	medium_impact	1.99	0.77	neutral	0.95	neutral	2.37	18.59	deleterious	0.29	0.45	NA	NA	0.21	neutral	0.38	neutral	0.2	neutral	6	0.99	deleterious	0.13	neutral	1	deleterious	0.70	deleterious	-2.59	low_impact	-0.07	medium_impact	0.84	medium_impact	0.40	0.8	18.95	18.03	0.47	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10854	10854	T	G	MI.16511	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	95	32	L	R	cTa/cGa	-4.09	0	0	probably_damaging	0.99	deleterious	0.01	neutral	1.34	deleterious	-3.44	deleterious	-3.89	medium_impact	3.23	0.59	damaging	0.12	damaging	3.93	23.50	deleterious	0.1	0.4	NA	NA	0.8	disease	0.73	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-2.59	low_impact	-0.92	medium_impact	2.07	high_impact	0.17	0.8	18.95	18.03	0.27	N	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10854	10854	T	C	MI.16512	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	95	32	L	P	cTa/cCa	-4.09	0	0	probably_damaging	1	deleterious	0	neutral	1.34	deleterious	-3.68	deleterious	-4.63	medium_impact	3.23	0.57	damaging	0.12	damaging	3.68	23.30	deleterious	0.1	0.4	NA	NA	0.78	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.07	high_impact	0.10	0.8	18.95	18.03	0.29	N	0.90	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10854	10854	T	A	MI.16513	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	95	32	L	Q	cTa/cAa	-4.09	0	0	probably_damaging	1	deleterious	0.02	neutral	1.34	deleterious	-3.58	deleterious	-3.86	medium_impact	3.23	0.65	neutral	0.17	damaging	3.85	23.40	deleterious	0.15	0.4	NA	NA	0.64	disease	0.61	disease	0.69	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.54	low_impact	-0.75	medium_impact	2.07	high_impact	0.14	0.8	18.95	18.03	0.31	N	0.93	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10856	10856	A	T	MI.16514	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	97	33	I	F	Att/Ttt	-9.62	0	0	possibly_damaging	0.51	neutral	0.64	neutral	1.49	neutral	-1	neutral	-1.67	low_impact	1.44	0.74	neutral	0.73	neutral	2.44	19.06	deleterious	0.12	0.4	NA	NA	0.48	neutral	0.4	neutral	0.31	neutral	4	0.43	neutral	0.57	deleterious	-3	neutral	0.70	deleterious	-0.73	medium_impact	0.34	medium_impact	0.3	medium_impact	0.34	0.8	22.88	20.34	0.32	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10856	10856	A	C	MI.16515	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	97	33	I	L	Att/Ctt	-9.62	0	0	benign	0.01	neutral	1	neutral	1.76	neutral	0.98	neutral	0.57	neutral_impact	-0.28	0.76	neutral	0.99	neutral	0.81	9.53	deleterious	0.22	0.45	NA	NA	0.1	neutral	0.29	neutral	0.18	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.58	deleterious	1.16	medium_impact	1.88	high_impact	-1.4	low_impact	0.28	0.8	22.88	20.34	0.33	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10856	10856	A	G	MI.16516	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	97	33	I	V	Att/Gtt	-9.62	0	0	benign	0.02	neutral	0.28	neutral	1.55	neutral	-0.3	neutral	-0.45	low_impact	1.44	0.78	neutral	0.84	neutral	1.65	14.14	neutral	0.31	0.45	NA	NA	0.17	neutral	0.4	neutral	0.23	neutral	5	0.71	neutral	0.63	deleterious	-6	neutral	0.60	deleterious	0.87	medium_impact	-0.03	medium_impact	0.3	medium_impact	0.42	0.8	22.88	20.34	0.45	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10857	10857	T	C	MI.16517	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	98	33	I	T	aTt/aCt	-9.62	0	0	benign	0.03	neutral	0.07	neutral	1.47	neutral	-1.31	neutral	-2.16	low_impact	1.09	0.79	neutral	0.85	neutral	1.97	16.02	deleterious	0.16	0.45	NA	NA	0.26	neutral	0.45	neutral	0.16	neutral	7	0.93	neutral	0.52	deleterious	-6	neutral	0.68	deleterious	0.7	medium_impact	-0.43	medium_impact	-0.05	medium_impact	0.24	0.8	22.88	20.34	0.43	N	0.14	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10857	10857	T	G	MI.16518	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	98	33	I	S	aTt/aGt	-9.62	0	0	benign	0.27	deleterious	0.02	neutral	1.48	neutral	-1.18	deleterious	-2.85	low_impact	1.17	0.73	neutral	0.8	neutral	3.98	23.60	deleterious	0.12	0.4	NA	NA	0.55	disease	0.53	disease	0.56	disease	1	0.98	neutral	0.38	neutral	-2	neutral	0.73	deleterious	-0.31	medium_impact	-0.75	medium_impact	0.03	medium_impact	0.26	0.8	22.88	20.34	0.38	N	0.64	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10857	10857	T	A	MI.16519	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	98	33	I	N	aTt/aAt	-9.62	0	0	possibly_damaging	0.59	deleterious	0	neutral	1.41	deleterious	-3.28	deleterious	-3.64	medium_impact	2.4	0.71	neutral	0.45	neutral	4.28	24.00	deleterious	0.17	0.45	NA	NA	0.62	disease	0.62	disease	0.73	disease	5	1	deleterious	0.21	neutral	4	deleterious	0.74	deleterious	-0.87	medium_impact	-1.48	low_impact	1.25	medium_impact	0.20	0.8	22.88	20.34	0.36	N	0.84	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8463	8463	A	G	MI.1652	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	98	33	Y	C	tAc/tGc	0.36	0	0	probably_damaging	1	neutral	0.18	neutral	1.55	deleterious	-4.48	deleterious	-6.96	medium_impact	2.69	1	neutral	0.4	neutral	3.99	23.60	deleterious	0.55776640	0.85	0.9	disease	0.34	neutral	0.77	disease	0.27	neutral	5	1	deleterious	0.09	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	-0.08	medium_impact	1.21	medium_impact	0.11	0.85	NA	NA	0.53	N	0.65	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10858	10858	T	G	MI.16520	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	99	33	I	M	atT/atG	1.91	0.02	0	benign	0.05	neutral	0.43	neutral	1.49	neutral	-0.96	neutral	0.02	low_impact	1.21	0.78	neutral	0.98	neutral	1.79	14.91	neutral	0.31	0.45	NA	NA	0.16	neutral	0.36	neutral	0.23	neutral	5	0.53	neutral	0.69	deleterious	-6	neutral	0.67	deleterious	0.48	medium_impact	0.13	medium_impact	0.07	medium_impact	0.40	0.8	22.88	20.34	0.43	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10858	10858	T	A	MI.16521	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	99	33	I	M	atT/atA	1.91	0.02	0	benign	0.05	neutral	0.43	neutral	1.49	neutral	-0.96	neutral	0.02	low_impact	1.21	0.78	neutral	0.98	neutral	2.11	16.95	deleterious	0.31	0.45	NA	NA	0.16	neutral	0.36	neutral	0.23	neutral	5	0.53	neutral	0.69	deleterious	-6	neutral	0.67	deleterious	0.48	medium_impact	0.13	medium_impact	0.07	medium_impact	0.40	0.8	22.88	20.34	0.43	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10859	10859	A	T	MI.16522	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	100	34	I	F	Att/Ttt	-1.55	0	0	probably_damaging	1	neutral	0.06	neutral	1.36	neutral	-1.79	deleterious	-2.96	medium_impact	2.87	0.69	neutral	0.15	damaging	3.51	23.10	deleterious	0.12	0.4	NA	NA	0.74	disease	0.61	disease	0.56	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.47	medium_impact	1.71	medium_impact	0.41	0.8	40.31	9.47	0.34	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10859	10859	A	G	MI.16523	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	100	34	I	V	Att/Gtt	-1.55	0	0	probably_damaging	1	neutral	0.08	neutral	1.42	neutral	-1.08	neutral	-0.71	medium_impact	3.07	0.79	neutral	0.72	neutral	1.76	14.75	neutral	0.42	0.55	NA	NA	0.3	neutral	0.47	neutral	0.16	neutral	7	1	deleterious	0.04	neutral	1	deleterious	0.66	deleterious	-3.54	low_impact	-0.39	medium_impact	1.91	medium_impact	0.49	0.8	40.31	9.47	0.48	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10859	10859	A	C	MI.16524	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	100	34	I	L	Att/Ctt	-1.55	0	0	probably_damaging	1	neutral	0.51	neutral	1.63	neutral	0.21	neutral	-1.37	low_impact	1.75	0.76	neutral	0.32	neutral	3.53	23.10	deleterious	0.26	0.45	NA	NA	0.45	neutral	0.38	neutral	0.2	neutral	6	1	deleterious	0.26	neutral	-2	neutral	0.68	deleterious	-3.54	low_impact	0.21	medium_impact	0.61	medium_impact	0.45	0.8	40.31	9.47	0.34	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10860	10860	T	C	MI.16525	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	101	34	I	T	aTt/aCt	3.75	0.99	0	probably_damaging	1	deleterious	0.04	neutral	1.34	neutral	-2.17	deleterious	-3.66	medium_impact	2.87	0.76	neutral	0.17	damaging	3.08	22.50	deleterious	0.18	0.45	NA	NA	0.66	disease	0.64	disease	0.67	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.57	medium_impact	1.71	medium_impact	0.28	0.8	40.31	9.47	0.52	P	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10860	10860	T	A	MI.16526	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	101	34	I	N	aTt/aAt	3.75	0.99	0	probably_damaging	1	deleterious	0	neutral	1.29	deleterious	-3.57	deleterious	-5.2	medium_impact	3.07	0.63	neutral	0.14	damaging	4.07	23.70	deleterious	0.18	0.45	NA	NA	0.77	disease	0.67	disease	0.7	disease	4	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	1.91	medium_impact	0.15	0.8	40.31	9.47	0.5	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10860	10860	T	G	MI.16527	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	101	34	I	S	aTt/aGt	3.75	0.99	0	probably_damaging	1	neutral	0.07	neutral	1.31	neutral	-2.84	deleterious	-4.44	medium_impact	3.42	0.71	neutral	0.16	damaging	3.99	23.60	deleterious	0.12	0.4	NA	NA	0.78	disease	0.64	disease	0.66	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.43	medium_impact	2.26	high_impact	0.21	0.8	40.31	9.47	0.55	P	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10861	10861	T	G	MI.16528	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	102	34	I	M	atT/atG	7.44	1	0	probably_damaging	1	neutral	0.14	neutral	1.35	neutral	-1.91	neutral	-2.14	medium_impact	3.07	0.78	neutral	0.17	damaging	3.20	22.70	deleterious	0.32	0.5	NA	NA	0.51	disease	0.46	neutral	0.44	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.24	medium_impact	1.91	medium_impact	0.38	0.8	40.31	9.47	0.6	P	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10861	10861	T	A	MI.16529	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	102	34	I	M	atT/atA	7.44	1	0	probably_damaging	1	neutral	0.14	neutral	1.35	neutral	-1.91	neutral	-2.14	medium_impact	3.07	0.78	neutral	0.17	damaging	3.58	23.20	deleterious	0.32	0.5	NA	NA	0.51	disease	0.46	neutral	0.44	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.24	medium_impact	1.91	medium_impact	0.38	0.8	40.31	9.47	0.6	P	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8463	8463	A	C	MI.1653	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	98	33	Y	S	tAc/tCc	0.36	0	0	probably_damaging	0.99	neutral	0.44	neutral	1.61	deleterious	-3.07	deleterious	-6.8	neutral_impact	0.68	0.99	neutral	0.85	neutral	4.10	23.70	deleterious	0.42207444	0.85	0.78	disease	0.33	neutral	0.65	disease	0.22	neutral	6	0.99	deleterious	0.23	neutral	-2	neutral	0.82	deleterious	-2.65	low_impact	0.23	medium_impact	-0.52	medium_impact	0.29	0.85	NA	NA	0.49	N	0.64	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10862	10862	A	C	MI.16530	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	103	35	S	R	Agc/Cgc	-6.16	0	0	probably_damaging	1	neutral	0.24	neutral	1.47	neutral	-2.37	deleterious	-2.65	medium_impact	3.02	0.63	neutral	0.44	neutral	3.59	23.20	deleterious	0.21	0.45	NA	NA	0.83	disease	0.7	disease	0.78	disease	6	1	deleterious	0.12	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.08	medium_impact	1.86	medium_impact	0.28	0.8	15.9	10.58	0.36	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10862	10862	A	T	MI.16531	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	103	35	S	C	Agc/Tgc	-6.16	0	0	probably_damaging	1	neutral	0.12	neutral	1.46	deleterious	-3.01	neutral	-2.27	medium_impact	3.02	0.76	neutral	0.6	neutral	3.12	22.60	deleterious	0.17	0.45	NA	NA	0.7	disease	0.5	neutral	0.54	disease	1	1	deleterious	0.06	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.28	medium_impact	1.86	medium_impact	0.20	0.8	15.9	10.58	0.4	N	0.53	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10862	10862	A	G	MI.16532	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	103	35	S	G	Agc/Ggc	-6.16	0	0	probably_damaging	1	neutral	0.27	neutral	1.49	neutral	-1.61	neutral	-1.98	medium_impact	2.68	0.78	neutral	0.7	neutral	3.30	22.90	deleterious	0.3	0.45	NA	NA	0.48	neutral	0.54	disease	0.45	neutral	1	1	deleterious	0.14	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.04	medium_impact	1.53	medium_impact	0.43	0.8	15.9	10.58	0.4	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10863	10863	G	T	MI.16533	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	104	35	S	I	aGc/aTc	0.75	0	0	probably_damaging	1	neutral	0.41	neutral	1.59	neutral	0.09	deleterious	-3.07	low_impact	1.88	0.64	neutral	0.63	neutral	3.90	23.50	deleterious	0.19	0.45	NA	NA	0.77	disease	0.58	disease	0.71	disease	4	1	deleterious	0.21	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	0.11	medium_impact	0.73	medium_impact	0.28	0.8	15.9	10.58	0.33	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10863	10863	G	C	MI.16534	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	104	35	S	T	aGc/aCc	0.75	0	0	probably_damaging	1	neutral	0.34	neutral	1.53	neutral	-0.64	neutral	-1.32	medium_impact	2.48	0.74	neutral	0.93	neutral	3.09	22.50	deleterious	0.32	0.5	NA	NA	0.37	neutral	0.38	neutral	0.17	neutral	7	1	deleterious	0.17	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.04	medium_impact	1.33	medium_impact	0.49	0.8	15.9	10.58	0.47	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10863	10863	G	A	MI.16535	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	104	35	S	N	aGc/aAc	0.75	0	0	probably_damaging	1	neutral	0.22	neutral	1.46	neutral	-2.6	neutral	-2	low_impact	1.48	0.73	neutral	0.86	neutral	2.28	18.05	deleterious	0.52	0.6	NA	NA	0.59	disease	0.58	disease	0.65	disease	3	1	deleterious	0.11	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	-0.11	medium_impact	0.34	medium_impact	0.41	0.8	15.9	10.58	0.39	N	0.52	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10865	10865	A	G	MI.16536	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	106	36	I	V	Atc/Gtc	-1.55	0	0	benign	0.05	neutral	0.16	neutral	1.63	neutral	0.33	neutral	-0.45	neutral_impact	0.34	0.77	neutral	0.82	neutral	-0.17	1.25	neutral	0.33	0.5	NA	NA	0.11	neutral	0.32	neutral	0.25	neutral	5	0.83	neutral	0.56	deleterious	-6	neutral	0.10	neutral	0.48	medium_impact	-0.2	medium_impact	-0.79	medium_impact	0.32	0.8	27.02	18.08	0.43	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10865	10865	A	T	MI.16537	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	106	36	I	F	Atc/Ttc	-1.55	0	0	benign	0.01	neutral	0.54	neutral	1.57	neutral	-0.18	neutral	-0.93	neutral_impact	-0.14	0.74	neutral	0.98	neutral	0.33	5.97	deleterious	0.13	0.4	NA	NA	0.28	neutral	0.27	neutral	0.16	neutral	7	0.45	neutral	0.77	deleterious	-6	neutral	0.12	neutral	1.16	medium_impact	0.24	medium_impact	-1.26	low_impact	0.40	0.8	27.02	18.08	0.37	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10865	10865	A	C	MI.16538	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	106	36	I	L	Atc/Ctc	-1.55	0	0	benign	0	neutral	1	neutral	1.72	neutral	0.86	neutral	0.79	neutral_impact	-1.88	0.78	neutral	0.98	neutral	-1.06	0.01	neutral	0.24	0.45	NA	NA	0.07	neutral	0.23	neutral	0.18	neutral	6	0	neutral	1	deleterious	-6	neutral	0.07	neutral	2.1	high_impact	1.88	high_impact	-2.99	low_impact	0.37	0.8	27.02	18.08	0.3	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10866	10866	T	C	MI.16539	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	107	36	I	T	aTc/aCc	-10.08	0	0	benign	0.11	neutral	0.36	neutral	1.5	neutral	-0.93	neutral	-1.29	neutral_impact	0.09	0.76	neutral	0.93	neutral	-0.02	2.38	deleterious	0.21	0.45	NA	NA	0.12	neutral	0.3	neutral	0.24	neutral	5	0.58	neutral	0.63	deleterious	-6	neutral	0.11	neutral	0.14	medium_impact	0.06	medium_impact	-1.04	low_impact	0.17	0.8	27.02	18.08	0.45	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8463	8463	A	T	MI.1654	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	98	33	Y	F	tAc/tTc	0.36	0	0	probably_damaging	0.97	neutral	0.73	neutral	1.6	neutral	-0.8	neutral	-1.42	neutral_impact	-0.37	0.99	neutral	0.96	neutral	2.16	17.23	deleterious	0.51274914	0.85	0.19	neutral	0.09	neutral	0.41	neutral	0.04	neutral	9	0.97	neutral	0.38	neutral	-2	neutral	0.70	deleterious	-2.19	low_impact	0.54	medium_impact	-1.42	low_impact	0.29	0.85	NA	NA	0.43	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10866	10866	T	G	MI.16540	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	107	36	I	S	aTc/aGc	-10.08	0	0	benign	0.01	neutral	0.32	neutral	1.48	neutral	-1.3	neutral	-1.67	neutral_impact	-0.2	0.68	neutral	0.85	neutral	0.99	10.59	neutral	0.08	0.35	NA	NA	0.34	neutral	0.33	neutral	0.13	neutral	7	0.67	neutral	0.66	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.02	medium_impact	-1.32	low_impact	0.24	0.8	27.02	18.08	0.43	N	0.03	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10866	10866	T	A	MI.16541	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	107	36	I	N	aTc/aAc	-10.08	0	0	benign	0.17	neutral	0.09	neutral	1.43	neutral	-2.86	deleterious	-2.64	low_impact	1.24	0.74	neutral	0.49	neutral	2.29	18.08	deleterious	0.14	0.4	NA	NA	0.46	neutral	0.54	disease	0.41	neutral	2	0.9	neutral	0.46	neutral	-6	neutral	0.17	neutral	-0.07	medium_impact	-0.36	medium_impact	0.1	medium_impact	0.20	0.8	27.02	18.08	0.43	N	0.21	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10867	10867	C	G	MI.16542	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	108	36	I	M	atC/atG	-0.17	0	0	benign	0.26	neutral	0.25	neutral	1.48	neutral	-1.34	neutral	0.06	neutral_impact	0.34	0.77	neutral	0.96	neutral	0.20	4.66	deleterious	0.3	0.45	NA	NA	0.12	neutral	0.28	neutral	0.24	neutral	5	0.7	neutral	0.5	deleterious	-6	neutral	0.34	neutral	-0.29	medium_impact	-0.07	medium_impact	-0.79	medium_impact	0.40	0.8	27.02	18.08	0.46	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10867	10867	C	A	MI.16543	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	108	36	I	M	atC/atA	-0.17	0	0	benign	0.26	neutral	0.25	neutral	1.48	neutral	-1.34	neutral	0.06	neutral_impact	0.34	0.77	neutral	0.96	neutral	0.72	8.98	deleterious	0.3	0.45	NA	NA	0.12	neutral	0.28	neutral	0.24	neutral	5	0.7	neutral	0.5	deleterious	-6	neutral	0.34	neutral	-0.29	medium_impact	-0.07	medium_impact	-0.79	medium_impact	0.40	0.8	27.02	18.08	0.46	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10868	10868	A	T	MI.16544	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	109	37	I	F	Atc/Ttc	-9.16	0	0	benign	0.17	neutral	1	neutral	1.49	neutral	-0.93	neutral	-1.72	low_impact	1.81	0.73	neutral	0.42	neutral	2.22	17.62	deleterious	0.14	0.4	NA	NA	0.39	neutral	0.32	neutral	0.16	neutral	7	0.17	neutral	0.92	deleterious	-6	neutral	0.70	deleterious	-0.07	medium_impact	1.88	high_impact	0.67	medium_impact	0.51	0.8	22.88	19.35	0.23	N	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10868	10868	A	G	MI.16545	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	109	37	I	V	Atc/Gtc	-9.16	0	0	possibly_damaging	0.73	neutral	0.21	neutral	1.55	neutral	-0.27	neutral	-0.25	low_impact	1.71	0.74	neutral	0.93	neutral	1.49	13.26	neutral	0.28	0.45	NA	NA	0.12	neutral	0.33	neutral	0.25	neutral	5	0.84	neutral	0.24	neutral	-3	neutral	0.61	deleterious	-1.12	low_impact	-0.12	medium_impact	0.57	medium_impact	0.55	0.8	22.88	19.35	0.48	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10868	10868	A	C	MI.16546	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	109	37	I	L	Atc/Ctc	-9.16	0	0	possibly_damaging	0.73	neutral	0.83	neutral	1.76	neutral	1.01	neutral	-0.6	neutral_impact	0.73	0.72	neutral	0.94	neutral	1.70	14.39	neutral	0.19	0.45	NA	NA	0.13	neutral	0.21	neutral	0.22	neutral	6	0.68	neutral	0.55	deleterious	-3	neutral	0.59	deleterious	-1.12	low_impact	0.59	medium_impact	-0.4	medium_impact	0.48	0.8	22.88	19.35	0.38	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10869	10869	T	A	MI.16547	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	110	37	I	N	aTc/aAc	-2.24	0	0	probably_damaging	0.98	neutral	0.15	neutral	1.41	deleterious	-3.25	deleterious	-3.18	medium_impact	2.91	0.69	neutral	0.21	damaging	4.24	23.90	deleterious	0.16	0.45	NA	NA	0.53	disease	0.57	disease	0.7	disease	4	0.99	deleterious	0.09	neutral	1	deleterious	0.73	deleterious	-2.31	low_impact	-0.22	medium_impact	1.75	medium_impact	0.18	0.8	22.88	19.35	0.33	N	0.74	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10869	10869	T	C	MI.16548	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	110	37	I	T	aTc/aCc	-2.24	0	0	probably_damaging	0.95	neutral	0.28	neutral	1.47	neutral	-1.23	neutral	-1.22	low_impact	1.32	0.73	neutral	0.97	neutral	1.65	14.11	neutral	0.18	0.45	NA	NA	0.24	neutral	0.36	neutral	0.17	neutral	7	0.96	neutral	0.17	neutral	-2	neutral	0.68	deleterious	-1.92	low_impact	-0.03	medium_impact	0.18	medium_impact	0.24	0.8	22.88	19.35	0.45	N	0.08	polymorphism	1	0.04	.	.	.	.	.	.	COSM1132244	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10869	10869	T	G	MI.16549	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	110	37	I	S	aTc/aGc	-2.24	0	0	probably_damaging	0.97	neutral	0.35	neutral	1.45	neutral	-1.74	neutral	-2.29	medium_impact	2.36	0.8	neutral	0.84	neutral	2.98	22.20	deleterious	0.09	0.35	NA	NA	0.49	neutral	0.46	neutral	0.46	neutral	1	0.97	neutral	0.19	neutral	1	deleterious	0.73	deleterious	-2.14	low_impact	0.05	medium_impact	1.21	medium_impact	0.26	0.8	22.88	19.35	0.36	N	0.31	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8465	8465	C	A	MI.1655	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	100	34	H	N	Cac/Aac	-2.19	0	0	probably_damaging	0.96	neutral	0.39	neutral	0.72	deleterious	-6.39	deleterious	-3.33	medium_impact	1.96	0.99	neutral	0.66	neutral	2.66	20.50	deleterious	0.74096869	0.85	0.35	neutral	0.18	neutral	0.48	neutral	0.12	neutral	8	0.96	neutral	0.22	neutral	1	deleterious	0.64	deleterious	-2.07	low_impact	0.18	medium_impact	0.58	medium_impact	0.58	0.85	10.29	8.62	0.51	N	0.48	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10870	10870	C	A	MI.16550	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	111	37	I	M	atC/atA	-0.17	0	0	probably_damaging	0.98	neutral	0.44	neutral	1.49	neutral	-1.03	neutral	-1.09	low_impact	1.71	0.72	neutral	0.88	neutral	2.37	18.66	deleterious	0.3	0.45	NA	NA	0.15	neutral	0.3	neutral	0.24	neutral	5	0.98	neutral	0.23	neutral	-2	neutral	0.67	deleterious	-2.31	low_impact	0.14	medium_impact	0.57	medium_impact	0.55	0.8	22.88	19.35	0.45	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10870	10870	C	G	MI.16551	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	111	37	I	M	atC/atG	-0.17	0	0	probably_damaging	0.98	neutral	0.44	neutral	1.49	neutral	-1.03	neutral	-1.09	low_impact	1.71	0.72	neutral	0.88	neutral	1.93	15.79	deleterious	0.3	0.45	NA	NA	0.15	neutral	0.3	neutral	0.24	neutral	5	0.98	neutral	0.23	neutral	-2	neutral	0.67	deleterious	-2.31	low_impact	0.14	medium_impact	0.57	medium_impact	0.55	0.8	22.88	19.35	0.45	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10871	10871	C	G	MI.16552	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	112	38	P	A	Cct/Gct	-8.93	0	0	possibly_damaging	0.62	neutral	0.44	neutral	1.67	neutral	2.16	neutral	1.16	neutral_impact	0.6	0.78	neutral	0.86	neutral	2.79	21.30	deleterious	0.23	0.45	NA	NA	0.11	neutral	0.25	neutral	0.26	neutral	5	0.63	neutral	0.41	neutral	-3	neutral	0.70	deleterious	-0.92	medium_impact	0.14	medium_impact	-0.53	medium_impact	0.66	0.8	28.76	30.68	0.36	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10871	10871	C	T	MI.16553	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	112	38	P	S	Cct/Tct	-8.93	0	0	benign	0.18	neutral	1	neutral	1.98	neutral	4.21	neutral	2.72	neutral_impact	-1.49	0.7	neutral	0.95	neutral	0.95	10.38	neutral	0.23	0.45	NA	NA	0.06	neutral	0.16	neutral	0.22	neutral	6	0.18	neutral	0.91	deleterious	-6	neutral	0.67	deleterious	-0.1	medium_impact	1.88	high_impact	-2.6	low_impact	0.15	0.8	28.76	30.68	0.37	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10871	10871	C	A	MI.16554	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	112	38	P	T	Cct/Act	-8.93	0	0	benign	0.18	neutral	0.35	neutral	1.67	neutral	2.17	neutral	1.41	neutral_impact	-0.34	0.76	neutral	0.9	neutral	2.36	18.57	deleterious	0.21	0.45	NA	NA	0.16	neutral	0.24	neutral	0.23	neutral	5	0.58	neutral	0.59	deleterious	-6	neutral	0.70	deleterious	-0.1	medium_impact	0.05	medium_impact	-1.46	low_impact	0.66	0.8	28.76	30.68	0.41	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10872	10872	C	G	MI.16555	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	113	38	P	R	cCt/cGt	0.75	0	0	probably_damaging	0.95	neutral	0.29	neutral	1.59	neutral	0.35	neutral	-0.37	low_impact	1.5	0.73	neutral	0.23	damaging	3.39	23.00	deleterious	0.09	0.35	NA	NA	0.55	disease	0.63	disease	0.71	disease	4	0.96	neutral	0.17	neutral	-2	neutral	0.79	deleterious	-1.92	low_impact	-0.02	medium_impact	0.36	medium_impact	0.48	0.8	28.76	30.68	0.36	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10872	10872	C	T	MI.16556	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	113	38	P	L	cCt/cTt	0.75	0	0	possibly_damaging	0.82	neutral	0.63	neutral	1.67	neutral	2.17	neutral	-0.76	low_impact	1.5	0.68	neutral	0.29	neutral	4.11	23.70	deleterious	0.15	0.4	NA	NA	0.32	neutral	0.35	neutral	0.15	neutral	7	0.79	neutral	0.41	neutral	-3	neutral	0.73	deleterious	-1.34	low_impact	0.33	medium_impact	0.36	medium_impact	0.58	0.8	28.76	30.68	0.36	N	0.82	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10872	10872	C	A	MI.16557	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	113	38	P	H	cCt/cAt	0.75	0	0	probably_damaging	0.98	neutral	0.43	neutral	1.58	neutral	-0.37	neutral	-0.46	low_impact	1.5	0.75	neutral	0.27	damaging	3.71	23.30	deleterious	0.13	0.4	NA	NA	0.29	neutral	0.6	disease	0.37	neutral	3	0.98	deleterious	0.23	neutral	-2	neutral	0.74	deleterious	-2.31	low_impact	0.13	medium_impact	0.36	medium_impact	0.40	0.8	28.76	30.68	0.36	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10874	10874	C	A	MI.16558	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	115	39	L	M	Cta/Ata	-0.63	0	0	probably_damaging	0.96	neutral	0.27	neutral	1.23	neutral	-2.9	neutral	-1.21	medium_impact	2.3	0.79	neutral	0.74	neutral	3.51	23.10	deleterious	0.31	0.45	NA	NA	0.33	neutral	0.46	neutral	0.17	neutral	7	0.96	neutral	0.16	neutral	1	deleterious	0.73	deleterious	-2.01	low_impact	-0.04	medium_impact	1.15	medium_impact	0.56	0.8	8.71	10.96	0.4	N	0.90	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10874	10874	C	G	MI.16559	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	115	39	L	V	Cta/Gta	-0.63	0	0	possibly_damaging	0.52	neutral	0.08	neutral	1.3	neutral	-1.75	neutral	-1.94	medium_impact	2.79	0.79	neutral	0.57	neutral	3.18	22.70	deleterious	0.32	0.5	NA	NA	0.45	neutral	0.6	disease	0.41	neutral	2	0.91	neutral	0.28	neutral	0	NA	0.76	deleterious	-0.75	medium_impact	-0.39	medium_impact	1.63	medium_impact	0.42	0.8	8.71	10.96	0.43	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8465	8465	C	T	MI.1656	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	100	34	H	Y	Cac/Tac	-2.19	0	0	probably_damaging	0.96	neutral	1	neutral	0.97	neutral	-2.06	neutral	-0.77	neutral_impact	0.22	1	neutral	0.96	neutral	0.87	9.91	deleterious	0.66348541	0.85	0.25	neutral	0.07	neutral	0.32	neutral	0.04	neutral	9	0.96	neutral	0.52	deleterious	-2	neutral	0.63	deleterious	-2.07	low_impact	1.98	high_impact	-0.91	medium_impact	0.26	0.85	10.29	8.62	0.36	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10875	10875	T	G	MI.16560	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	116	39	L	R	cTa/cGa	-1.78	0	0	probably_damaging	0.98	deleterious	0.01	neutral	1.19	deleterious	-4.23	deleterious	-4.26	medium_impact	3.34	0.56	damaging	0.34	neutral	3.87	23.50	deleterious	0.06	0.35	NA	NA	0.8	disease	0.79	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.88	deleterious	-2.31	low_impact	-0.92	medium_impact	2.18	high_impact	0.18	0.8	8.71	10.96	0.4	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10875	10875	T	C	MI.16561	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	116	39	L	P	cTa/cCa	-1.78	0	0	probably_damaging	0.98	deleterious	0.04	neutral	1.18	deleterious	-4.81	deleterious	-4.89	medium_impact	3.34	0.53	damaging	0.31	neutral	3.62	23.20	deleterious	0.05	0.35	NA	NA	0.76	disease	0.78	disease	0.76	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.88	deleterious	-2.31	low_impact	-0.57	medium_impact	2.18	high_impact	0.15	0.8	8.71	10.96	0.42	N	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10875	10875	T	A	MI.16562	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	116	39	L	Q	cTa/cAa	-1.78	0	0	probably_damaging	0.98	deleterious	0.01	neutral	1.19	deleterious	-4.39	deleterious	-4.21	medium_impact	3.34	0.65	neutral	0.41	neutral	3.78	23.40	deleterious	0.1	0.4	NA	NA	0.71	disease	0.68	disease	0.69	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-2.31	low_impact	-0.92	medium_impact	2.18	high_impact	0.13	0.8	8.71	10.96	0.36	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10877	10877	C	A	MI.16563	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	118	40	L	M	Cta/Ata	-4.78	0	0	benign	0.12	neutral	0.38	neutral	1.43	neutral	-1.32	neutral	-0.12	neutral_impact	0.68	0.76	neutral	0.94	neutral	1.93	15.76	deleterious	0.28	0.45	NA	NA	0.09	neutral	0.36	neutral	0.26	neutral	5	0.56	neutral	0.63	deleterious	-6	neutral	0.68	deleterious	0.1	medium_impact	0.08	medium_impact	-0.45	medium_impact	0.57	0.8	23.75	22.06	0.41	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10877	10877	C	G	MI.16564	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	118	40	L	V	Cta/Gta	-4.78	0	0	benign	0.03	neutral	0.54	neutral	1.48	neutral	-0.8	neutral	-0.58	low_impact	1.15	0.79	neutral	0.83	neutral	1.32	12.36	neutral	0.3	0.45	NA	NA	0.18	neutral	0.45	neutral	0.22	neutral	6	0.43	neutral	0.76	deleterious	-6	neutral	0.70	deleterious	0.7	medium_impact	0.24	medium_impact	0.01	medium_impact	0.64	0.8	23.75	22.06	0.29	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10878	10878	T	G	MI.16565	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	119	40	L	R	cTa/cGa	-7.09	0	0	possibly_damaging	0.78	neutral	0.35	neutral	1.35	deleterious	-3.26	neutral	-1.59	medium_impact	2.12	0.71	neutral	0.49	neutral	2.38	18.71	deleterious	0.04	0.35	NA	NA	0.61	disease	0.64	disease	0.73	disease	5	0.8	neutral	0.29	neutral	0	NA	0.79	deleterious	-1.23	low_impact	0.05	medium_impact	0.97	medium_impact	0.21	0.8	23.75	22.06	0.33	N	0.58	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10878	10878	T	A	MI.16566	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	119	40	L	Q	cTa/cAa	-7.09	0	0	possibly_damaging	0.83	neutral	0.39	neutral	1.37	neutral	-2.51	neutral	-1.33	low_impact	1.02	0.75	neutral	0.8	neutral	2.54	19.69	deleterious	0.06	0.35	NA	NA	0.25	neutral	0.38	neutral	0.15	neutral	7	0.83	neutral	0.28	neutral	-3	neutral	0.70	deleterious	-1.37	low_impact	0.09	medium_impact	-0.12	medium_impact	0.23	0.8	23.75	22.06	0.39	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10878	10878	T	C	MI.16567	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	119	40	L	P	cTa/cCa	-7.09	0	0	probably_damaging	0.93	neutral	0.25	neutral	1.35	deleterious	-3.18	neutral	-1.22	low_impact	1.23	0.76	neutral	0.97	neutral	2.21	17.55	deleterious	0.04	0.35	NA	NA	0.6	disease	0.59	disease	0.48	neutral	0	0.95	neutral	0.16	neutral	-2	neutral	0.79	deleterious	-1.77	low_impact	-0.07	medium_impact	0.09	medium_impact	0.23	0.8	23.75	22.06	0.36	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10880	10880	T	C	MI.16568	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	121	41	F	L	Ttt/Ctt	-10.78	0	0	benign	0.05	neutral	0.83	neutral	1.8	neutral	1.7	neutral	-0.16	neutral_impact	-0.1	0.74	neutral	0.98	neutral	1.67	14.23	neutral	0.21	0.45	NA	NA	0.21	neutral	0.3	neutral	0.18	neutral	6	0.08	neutral	0.89	deleterious	-6	neutral	0.69	deleterious	0.48	medium_impact	0.59	medium_impact	-1.23	low_impact	0.47	0.8	27.23	22.95	0.36	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10880	10880	T	G	MI.16569	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	121	41	F	V	Ttt/Gtt	-10.78	0	0	possibly_damaging	0.54	neutral	0.31	neutral	1.64	neutral	0.61	neutral	-1.04	low_impact	1.38	0.72	neutral	0.76	neutral	3.68	23.30	deleterious	0.15	0.45	NA	NA	0.46	neutral	0.46	neutral	0.25	neutral	5	0.68	neutral	0.39	neutral	-3	neutral	0.73	deleterious	-0.78	medium_impact	0.01	medium_impact	0.24	medium_impact	0.38	0.8	27.23	22.95	0.45	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8465	8465	C	G	MI.1657	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	100	34	H	D	Cac/Gac	-2.19	0	0	probably_damaging	0.97	neutral	0.2	neutral	0.71	deleterious	-7.1	deleterious	-3.97	medium_impact	2.5	1	neutral	0.47	neutral	2.57	19.92	deleterious	0.41328743	0.85	0.34	neutral	0.22	neutral	0.54	disease	0.14	neutral	7	0.98	deleterious	0.12	neutral	1	deleterious	0.68	deleterious	-2.19	low_impact	-0.05	medium_impact	1.05	medium_impact	0.63	0.85	10.29	8.62	0.57	P	0.62	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10880	10880	T	A	MI.16570	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	121	41	F	I	Ttt/Att	-10.78	0	0	possibly_damaging	0.66	neutral	0.46	neutral	1.66	neutral	0.79	neutral	-0.85	low_impact	1.16	0.8	neutral	0.9	neutral	4.07	23.70	deleterious	0.18	0.45	NA	NA	0.44	neutral	0.45	neutral	0.21	neutral	6	0.65	neutral	0.4	neutral	-3	neutral	0.75	deleterious	-0.99	medium_impact	0.16	medium_impact	0.02	medium_impact	0.41	0.8	27.23	22.95	0.39	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10881	10881	T	C	MI.16571	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	122	41	F	S	tTt/tCt	-0.86	0	0	benign	0.09	neutral	0.44	neutral	1.56	neutral	-0.33	neutral	-1.79	low_impact	1.5	0.77	neutral	0.73	neutral	4.07	23.70	deleterious	0.06	0.35	NA	NA	0.39	neutral	0.41	neutral	0.15	neutral	7	0.5	neutral	0.68	deleterious	-6	neutral	0.75	deleterious	0.23	medium_impact	0.14	medium_impact	0.36	medium_impact	0.24	0.8	27.23	22.95	0.35	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10881	10881	T	G	MI.16572	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	122	41	F	C	tTt/tGt	-0.86	0	0	probably_damaging	0.98	neutral	0.1	neutral	1.51	neutral	-1.98	neutral	-1.71	medium_impact	2.19	0.75	neutral	0.48	neutral	3.87	23.50	deleterious	0.09	0.35	NA	NA	0.56	disease	0.51	disease	0.53	disease	1	0.99	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-2.31	low_impact	-0.33	medium_impact	1.04	medium_impact	0.23	0.8	27.23	22.95	0.42	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10881	10881	T	A	MI.16573	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	122	41	F	Y	tTt/tAt	-0.86	0	0	possibly_damaging	0.84	neutral	0.72	neutral	1.53	neutral	-1.24	neutral	0.03	low_impact	1.5	0.78	neutral	0.99	neutral	3.02	22.30	deleterious	0.18	0.45	NA	NA	0.29	neutral	0.36	neutral	0.15	neutral	7	0.8	neutral	0.44	neutral	-3	neutral	0.73	deleterious	-1.39	low_impact	0.43	medium_impact	0.36	medium_impact	0.49	0.8	27.23	22.95	0.37	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10882	10882	T	A	MI.16574	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	123	41	F	L	ttT/ttA	-0.63	0	0	benign	0.05	neutral	0.83	neutral	1.8	neutral	1.7	neutral	-0.16	neutral_impact	-0.1	0.74	neutral	0.98	neutral	2.13	17.05	deleterious	0.21	0.45	NA	NA	0.21	neutral	0.3	neutral	0.18	neutral	6	0.08	neutral	0.89	deleterious	-6	neutral	0.69	deleterious	0.48	medium_impact	0.59	medium_impact	-1.23	low_impact	0.47	0.8	27.23	22.95	0.37	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10882	10882	T	G	MI.16575	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	123	41	F	L	ttT/ttG	-0.63	0	0	benign	0.05	neutral	0.83	neutral	1.8	neutral	1.7	neutral	-0.16	neutral_impact	-0.1	0.74	neutral	0.98	neutral	1.94	15.81	deleterious	0.21	0.45	NA	NA	0.21	neutral	0.3	neutral	0.18	neutral	6	0.08	neutral	0.89	deleterious	-6	neutral	0.69	deleterious	0.48	medium_impact	0.59	medium_impact	-1.23	low_impact	0.47	0.8	27.23	22.95	0.37	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10883	10883	T	G	MI.16576	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	124	42	F	V	Ttt/Gtt	-5.7	0	0	benign	0.25	neutral	0.08	neutral	1.56	neutral	-0.23	neutral	-0.18	low_impact	1.92	0.72	neutral	0.74	neutral	1.76	14.76	neutral	0.19	0.45	NA	NA	0.53	disease	0.55	disease	0.6	disease	2	0.91	neutral	0.42	neutral	-6	neutral	0.18	neutral	-0.27	medium_impact	-0.39	medium_impact	0.77	medium_impact	0.43	0.8	23.09	29.17	0.43	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10883	10883	T	C	MI.16577	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	124	42	F	L	Ttt/Ctt	-5.7	0	0	benign	0.01	neutral	1	neutral	1.81	neutral	1.31	neutral	1.36	neutral_impact	-0.88	0.74	neutral	0.98	neutral	-0.95	0.02	neutral	0.25	0.45	NA	NA	0.1	neutral	0.31	neutral	0.19	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.16	medium_impact	1.88	high_impact	-2	low_impact	0.57	0.8	23.09	29.17	0.31	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10883	10883	T	A	MI.16578	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	124	42	F	I	Ttt/Att	-5.7	0	0	benign	0.17	neutral	0.11	neutral	1.58	neutral	-0.05	neutral	0.48	low_impact	1.72	0.75	neutral	0.94	neutral	1.03	10.83	neutral	0.14	0.4	NA	NA	0.49	neutral	0.43	neutral	0.44	neutral	1	0.87	neutral	0.47	deleterious	-6	neutral	0.19	neutral	-0.07	medium_impact	-0.31	medium_impact	0.58	medium_impact	0.52	0.8	23.09	29.17	0.51	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10884	10884	T	A	MI.16579	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	125	42	F	Y	tTt/tAt	-1.55	0	0	possibly_damaging	0.6	neutral	0.07	neutral	1.45	neutral	-2.11	neutral	-0.88	medium_impact	2.27	0.73	neutral	0.78	neutral	2.14	17.09	deleterious	0.21	0.45	NA	NA	0.4	neutral	0.51	disease	0.22	neutral	6	0.93	neutral	0.24	neutral	0	NA	0.30	neutral	-0.88	medium_impact	-0.43	medium_impact	1.12	medium_impact	0.59	0.8	23.09	29.17	0.51	P	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8466	8466	A	T	MI.1658	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	101	34	H	L	cAc/cTc	-0.57	0	0	probably_damaging	0.97	neutral	0.68	neutral	0.74	deleterious	-5.06	deleterious	-4.4	low_impact	1	1	neutral	0.71	neutral	2.73	21.00	deleterious	0.59410459	0.85	0.32	neutral	0.22	neutral	0.46	neutral	0.13	neutral	7	0.97	neutral	0.36	neutral	-2	neutral	0.68	deleterious	-2.19	low_impact	0.48	medium_impact	-0.24	medium_impact	0.33	0.85	10.29	8.62	0.38	N	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10884	10884	T	C	MI.16580	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	125	42	F	S	tTt/tCt	-1.55	0	0	benign	0.03	neutral	0.05	neutral	1.48	neutral	-1.48	neutral	-2.14	low_impact	1.57	0.74	neutral	0.7	neutral	2.15	17.16	deleterious	0.06	0.35	NA	NA	0.51	disease	0.56	disease	0.6	disease	2	0.95	neutral	0.51	deleterious	-6	neutral	0.37	neutral	0.7	medium_impact	-0.52	medium_impact	0.43	medium_impact	0.19	0.8	23.09	29.17	0.44	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10884	10884	T	G	MI.16581	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	125	42	F	C	tTt/tGt	-1.55	0	0	probably_damaging	0.92	deleterious	0.03	neutral	1.43	deleterious	-3.16	neutral	-1.67	medium_impact	2.27	0.67	neutral	0.45	neutral	3.60	23.20	deleterious	0.09	0.35	NA	NA	0.65	disease	0.58	disease	0.72	disease	4	0.99	deleterious	0.06	neutral	5	deleterious	0.65	deleterious	-1.71	low_impact	-0.64	medium_impact	1.12	medium_impact	0.19	0.8	23.09	29.17	0.37	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10885	10885	T	G	MI.16582	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	126	42	F	L	ttT/ttG	7.44	0.96	0	benign	0.01	neutral	1	neutral	1.81	neutral	1.31	neutral	1.36	neutral_impact	-0.88	0.74	neutral	0.98	neutral	-0.60	0.13	neutral	0.25	0.45	NA	NA	0.1	neutral	0.31	neutral	0.19	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.16	medium_impact	1.88	high_impact	-2	low_impact	0.57	0.8	23.09	29.17	0.51	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10885	10885	T	A	MI.16583	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	126	42	F	L	ttT/ttA	7.44	0.96	0	benign	0.01	neutral	1	neutral	1.81	neutral	1.31	neutral	1.36	neutral_impact	-0.88	0.74	neutral	0.98	neutral	-0.49	0.24	neutral	0.25	0.45	NA	NA	0.1	neutral	0.31	neutral	0.19	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.16	medium_impact	1.88	high_impact	-2	low_impact	0.57	0.8	23.09	29.17	0.52	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10886	10886	A	G	MI.16584	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	127	43	N	D	Aac/Gac	-7.55	0	0	benign	0.36	neutral	0.2	neutral	1.46	neutral	-1.86	neutral	-2.06	low_impact	1.62	0.79	neutral	0.44	neutral	0.68	8.69	deleterious	0.54	0.6	NA	NA	0.51	disease	0.6	disease	0.68	disease	4	0.76	neutral	0.42	neutral	-6	neutral	0.42	neutral	-0.48	medium_impact	-0.14	medium_impact	0.48	medium_impact	0.31	0.8	32.68	25.6	0.32	N	0.70	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10886	10886	A	T	MI.16585	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	127	43	N	Y	Aac/Tac	-7.55	0	0	benign	0.03	neutral	1	neutral	1.49	neutral	-1.23	neutral	-1.81	medium_impact	2.17	0.75	neutral	0.94	neutral	1.38	12.70	neutral	0.13	0.4	NA	NA	0.64	disease	0.34	neutral	0.49	neutral	0	0.03	neutral	0.99	deleterious	-3	neutral	0.71	deleterious	0.7	medium_impact	1.88	high_impact	1.02	medium_impact	0.24	0.8	32.68	25.6	0.28	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10886	10886	A	C	MI.16586	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	127	43	N	H	Aac/Cac	-7.55	0	0	benign	0.02	neutral	0.52	neutral	1.46	neutral	-1.96	neutral	-1.24	low_impact	1	0.76	neutral	0.92	neutral	1.19	11.68	neutral	0.4	0.5	NA	NA	0.56	disease	0.36	neutral	0.47	neutral	1	0.46	neutral	0.75	deleterious	-6	neutral	0.69	deleterious	0.87	medium_impact	0.22	medium_impact	-0.14	medium_impact	0.17	0.8	32.68	25.6	0.31	N	0.31	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10887	10887	A	T	MI.16587	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	128	43	N	I	aAc/aTc	-0.4	0	0	possibly_damaging	0.75	neutral	0.43	neutral	1.47	neutral	-1.76	deleterious	-3.47	low_impact	1.72	0.79	neutral	0.68	neutral	2.13	17.03	deleterious	0.13	0.4	NA	NA	0.73	disease	0.32	neutral	0.54	disease	1	0.75	neutral	0.34	neutral	-3	neutral	0.66	deleterious	-1.17	low_impact	0.13	medium_impact	0.58	medium_impact	0.16	0.8	32.68	25.6	0.28	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10887	10887	A	G	MI.16588	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	128	43	N	S	aAc/aGc	-0.4	0	0	benign	0.03	neutral	0.44	neutral	1.57	neutral	-0.11	neutral	-1.52	low_impact	1.05	0.73	neutral	0.95	neutral	-0.38	0.43	neutral	0.55	0.6	NA	NA	0.42	neutral	0.56	disease	0.36	neutral	3	0.53	neutral	0.71	deleterious	-6	neutral	0.17	neutral	0.7	medium_impact	0.14	medium_impact	-0.09	medium_impact	0.15	0.8	32.68	25.6	0.38	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10887	10887	A	C	MI.16589	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	128	43	N	T	aAc/aCc	-0.4	0	0	benign	0.36	neutral	0.4	neutral	1.51	neutral	-0.92	neutral	-1.89	low_impact	1.72	0.75	neutral	0.74	neutral	0.07	3.32	deleterious	0.38	0.5	NA	NA	0.46	neutral	0.46	neutral	0.24	neutral	5	0.53	neutral	0.52	deleterious	-6	neutral	0.34	neutral	-0.48	medium_impact	0.1	medium_impact	0.58	medium_impact	0.23	0.8	32.68	25.6	0.39	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8466	8466	A	C	MI.1659	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	101	34	H	P	cAc/cCc	-0.57	0	0	probably_damaging	0.98	neutral	0.39	neutral	0.71	deleterious	-7.32	neutral	-1.59	neutral_impact	0.24	0.99	neutral	0.97	neutral	2.02	16.31	deleterious	0.49682067	0.85	0.09	neutral	0.22	neutral	0.43	neutral	0.09	neutral	8	0.98	deleterious	0.21	neutral	-2	neutral	0.68	deleterious	-2.36	low_impact	0.18	medium_impact	-0.89	medium_impact	0.41	0.85	10.29	8.62	0.44	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10888	10888	C	G	MI.16590	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	129	43	N	K	aaC/aaG	0.06	0	0	benign	0.36	neutral	0.37	neutral	1.56	neutral	-0.26	neutral	-1.51	low_impact	1.48	0.73	neutral	0.7	neutral	-0.33	0.56	neutral	0.46	0.55	NA	NA	0.37	neutral	0.62	disease	0.36	neutral	3	0.56	neutral	0.51	deleterious	-6	neutral	0.40	neutral	-0.48	medium_impact	0.07	medium_impact	0.34	medium_impact	0.47	0.8	32.68	25.6	0.37	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10888	10888	C	A	MI.16591	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	129	43	N	K	aaC/aaA	0.06	0	0	benign	0.36	neutral	0.37	neutral	1.56	neutral	-0.26	neutral	-1.51	low_impact	1.48	0.73	neutral	0.7	neutral	0.11	3.71	deleterious	0.46	0.55	NA	NA	0.37	neutral	0.62	disease	0.36	neutral	3	0.56	neutral	0.51	deleterious	-6	neutral	0.40	neutral	-0.48	medium_impact	0.07	medium_impact	0.34	medium_impact	0.47	0.8	32.68	25.6	0.36	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10889	10889	C	G	MI.16592	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	130	44	Q	E	Caa/Gaa	-5.01	0	0	possibly_damaging	0.88	neutral	0.27	neutral	1.55	neutral	0.2	neutral	-1.22	medium_impact	2.8	0.79	neutral	0.53	neutral	1.39	12.71	neutral	0.33	0.5	NA	NA	0.33	neutral	0.47	neutral	0.16	neutral	7	0.9	neutral	0.2	neutral	0	NA	0.71	deleterious	-1.53	low_impact	-0.04	medium_impact	1.64	medium_impact	0.32	0.8	28.76	21.01	0.39	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10889	10889	C	A	MI.16593	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	130	44	Q	K	Caa/Aaa	-5.01	0	0	possibly_damaging	0.89	neutral	0.29	neutral	1.57	neutral	0.16	neutral	-1.4	medium_impact	2.8	0.79	neutral	0.56	neutral	2.29	18.12	deleterious	0.21	0.45	NA	NA	0.42	neutral	0.49	neutral	0.16	neutral	7	0.91	neutral	0.2	neutral	0	NA	0.72	deleterious	-1.57	low_impact	-0.02	medium_impact	1.64	medium_impact	0.44	0.8	28.76	21.01	0.43	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10890	10890	A	T	MI.16594	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	131	44	Q	L	cAa/cTa	-0.17	0	0	possibly_damaging	0.61	neutral	0.66	neutral	1.63	neutral	-1.04	deleterious	-2.57	low_impact	1.75	0.72	neutral	0.66	neutral	1.48	13.21	neutral	0.11	0.4	NA	NA	0.33	neutral	0.41	neutral	0.14	neutral	7	0.54	neutral	0.53	deleterious	-3	neutral	0.72	deleterious	-0.9	medium_impact	0.36	medium_impact	0.61	medium_impact	0.12	0.8	28.76	21.01	0.32	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10890	10890	A	C	MI.16595	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	131	44	Q	P	cAa/cCa	-0.17	0	0	probably_damaging	0.98	neutral	0.22	neutral	1.54	neutral	-1.57	deleterious	-2.57	low_impact	1.51	0.74	neutral	0.64	neutral	1.72	14.51	neutral	0.06	0.35	NA	NA	0.41	neutral	0.55	disease	0.33	neutral	3	0.99	deleterious	0.12	neutral	-2	neutral	0.77	deleterious	-2.31	low_impact	-0.11	medium_impact	0.37	medium_impact	0.32	0.8	28.76	21.01	0.38	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10890	10890	A	G	MI.16596	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	131	44	Q	R	cAa/cGa	-0.17	0	0	probably_damaging	0.94	neutral	0.35	neutral	1.54	neutral	-0.54	neutral	-1.51	medium_impact	2.44	0.83	neutral	0.64	neutral	1.73	14.57	neutral	0.23	0.45	NA	NA	0.39	neutral	0.53	disease	0.34	neutral	3	0.94	neutral	0.21	neutral	1	deleterious	0.75	deleterious	-1.84	low_impact	0.05	medium_impact	1.29	medium_impact	0.11	0.8	28.76	21.01	0.37	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10891	10891	A	C	MI.16597	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	132	44	Q	H	caA/caC	1.68	0	0	probably_damaging	0.99	neutral	0.54	neutral	1.54	neutral	-1.37	neutral	-1.53	medium_impact	2.1	0.75	neutral	0.88	neutral	1.00	10.68	neutral	0.29	0.45	NA	NA	0.23	neutral	0.27	neutral	0.16	neutral	7	0.99	deleterious	0.28	neutral	1	deleterious	0.73	deleterious	-2.59	low_impact	0.24	medium_impact	0.95	medium_impact	0.56	0.8	28.76	21.01	0.39	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10891	10891	A	T	MI.16598	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	132	44	Q	H	caA/caT	1.68	0	0	probably_damaging	0.99	neutral	0.54	neutral	1.54	neutral	-1.37	neutral	-1.53	medium_impact	2.1	0.75	neutral	0.88	neutral	1.17	11.60	neutral	0.29	0.45	NA	NA	0.23	neutral	0.27	neutral	0.16	neutral	7	0.99	deleterious	0.28	neutral	1	deleterious	0.73	deleterious	-2.59	low_impact	0.24	medium_impact	0.95	medium_impact	0.56	0.8	28.76	21.01	0.39	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10892	10892	A	T	MI.16599	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	133	45	I	F	Atc/Ttc	-2.48	0	0.01	possibly_damaging	0.49	neutral	0.72	neutral	1.57	neutral	-1.41	neutral	-0.11	neutral_impact	-1.01	0.78	neutral	0.97	neutral	-0.58	0.14	neutral	0.16	0.45	NA	NA	0.21	neutral	0.2	neutral	0.18	neutral	6	0.39	neutral	0.62	deleterious	-3	neutral	0.27	neutral	-0.7	medium_impact	0.43	medium_impact	-2.13	low_impact	0.61	0.8	35.08	27.64	0.31	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8603	8603	T	A	MI.166	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	77	26	F	Y	tTt/tAt	-0.33	0	0	benign	0.21	neutral	0.07	neutral	4.3	neutral	-1.05	neutral	-1.92	medium_impact	2.04	0.85	neutral	0.62	neutral	2.39	18.78	deleterious	0.35	0.65	0.78	disease	0.42	neutral	0.39	neutral	0.66	disease	3	0.92	neutral	0.43	neutral	-3	neutral	0.36	neutral	-0.21	medium_impact	-0.34	medium_impact	0.65	medium_impact	0.49	0.9	15.49	8.03	0.44	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8466	8466	A	G	MI.1660	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	101	34	H	R	cAc/cGc	-0.57	0	0	probably_damaging	0.97	neutral	0.38	neutral	0.72	deleterious	-6.46	deleterious	-3.64	medium_impact	2.5	0.99	neutral	0.5	neutral	2.15	17.16	deleterious	0.73708172	0.85	0.31	neutral	0.2	neutral	0.46	neutral	0.13	neutral	7	0.97	neutral	0.21	neutral	1	deleterious	0.69	deleterious	-2.19	low_impact	0.17	medium_impact	1.05	medium_impact	0.29	0.85	10.29	8.62	0.52	N	0.48	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10892	10892	A	C	MI.16600	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	133	45	I	L	Atc/Ctc	-2.48	0	0.01	benign	0.05	neutral	0.67	neutral	1.61	neutral	-0.23	neutral	0.18	neutral_impact	-0.12	0.72	neutral	0.97	neutral	-0.69	0.08	neutral	0.26	0.45	NA	NA	0.08	neutral	0.28	neutral	0.22	neutral	6	0.26	neutral	0.81	deleterious	-6	neutral	0.08	neutral	0.48	medium_impact	0.37	medium_impact	-1.25	low_impact	0.48	0.8	35.08	27.64	0.39	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10892	10892	A	G	MI.16601	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	133	45	I	V	Atc/Gtc	-2.48	0	0.01	benign	0.05	neutral	0.51	neutral	1.6	neutral	-0.14	neutral	0.13	neutral_impact	0.34	0.81	neutral	0.8	neutral	-1.05	0.01	neutral	0.55	0.6	NA	NA	0.06	neutral	0.35	neutral	0.19	neutral	6	0.44	neutral	0.73	deleterious	-6	neutral	0.07	neutral	0.48	medium_impact	0.21	medium_impact	-0.79	medium_impact	0.42	0.8	35.08	27.64	0.37	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10893	10893	T	C	MI.16602	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	134	45	I	T	aTc/aCc	-2.94	0	0	benign	0	neutral	0.41	neutral	1.61	neutral	-1.19	neutral	1.08	neutral_impact	-1.07	0.73	neutral	0.96	neutral	-0.60	0.13	neutral	0.23	0.45	NA	NA	0.08	neutral	0.26	neutral	0.22	neutral	6	0.59	neutral	0.71	deleterious	-6	neutral	0.08	neutral	2.1	high_impact	0.11	medium_impact	-2.18	low_impact	0.31	0.8	35.08	27.64	0.4	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10893	10893	T	G	MI.16603	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	134	45	I	S	aTc/aGc	-2.94	0	0	benign	0.01	neutral	0.43	neutral	1.69	neutral	-1.12	neutral	0.9	neutral_impact	-1.18	0.73	neutral	0.97	neutral	0.39	6.51	deleterious	0.1	0.4	NA	NA	0.16	neutral	0.27	neutral	0.22	neutral	6	0.56	neutral	0.71	deleterious	-6	neutral	0.12	neutral	1.16	medium_impact	0.13	medium_impact	-2.29	low_impact	0.22	0.8	35.08	27.64	0.4	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10893	10893	T	A	MI.16604	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	134	45	I	N	aTc/aAc	-2.94	0	0	benign	0.11	neutral	0.32	neutral	1.67	neutral	-2.47	neutral	0.57	neutral_impact	-1.32	0.72	neutral	0.97	neutral	0.87	9.88	deleterious	0.2	0.45	NA	NA	0.29	neutral	0.26	neutral	0.16	neutral	7	0.63	neutral	0.61	deleterious	-6	neutral	0.21	neutral	0.14	medium_impact	0.02	medium_impact	-2.43	low_impact	0.15	0.8	35.08	27.64	0.42	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10894	10894	C	G	MI.16605	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	135	45	I	M	atC/atG	-1.32	0	0	possibly_damaging	0.68	neutral	0.24	neutral	1.58	neutral	-1.8	neutral	0.45	neutral_impact	-0.46	0.73	neutral	0.95	neutral	0.11	3.74	deleterious	0.41	0.5	NA	NA	0.06	neutral	0.2	neutral	0.21	neutral	6	0.8	neutral	0.28	neutral	-3	neutral	0.39	neutral	-1.03	low_impact	-0.08	medium_impact	-1.58	low_impact	0.61	0.8	35.08	27.64	0.52	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10894	10894	C	A	MI.16606	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	135	45	I	M	atC/atA	-1.32	0	0	possibly_damaging	0.68	neutral	0.24	neutral	1.58	neutral	-1.8	neutral	0.45	neutral_impact	-0.46	0.73	neutral	0.95	neutral	0.57	7.95	deleterious	0.41	0.5	NA	NA	0.06	neutral	0.2	neutral	0.21	neutral	6	0.8	neutral	0.28	neutral	-3	neutral	0.39	neutral	-1.03	low_impact	-0.08	medium_impact	-1.58	low_impact	0.61	0.8	35.08	27.64	0.52	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10895	10895	A	T	MI.16607	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	136	46	N	Y	Aac/Tac	-20	0	0	probably_damaging	0.96	neutral	1	neutral	1.54	neutral	-2.22	neutral	-1.59	medium_impact	2.03	0.78	neutral	0.71	neutral	2.21	17.57	deleterious	0.15	0.4	NA	NA	0.33	neutral	0.29	neutral	0.16	neutral	7	0.96	neutral	0.52	deleterious	1	deleterious	0.66	deleterious	-2.01	low_impact	1.88	high_impact	0.88	medium_impact	0.22	0.8	19.61	16.67	0.24	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10895	10895	A	G	MI.16608	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	136	46	N	D	Aac/Gac	-20	0	0	benign	0.05	neutral	0.29	neutral	1.57	neutral	-0.64	neutral	-0.15	low_impact	1.48	0.78	neutral	0.95	neutral	0.27	5.45	deleterious	0.51	0.6	NA	NA	0.21	neutral	0.49	neutral	0.18	neutral	6	0.69	neutral	0.62	deleterious	-6	neutral	0.11	neutral	0.48	medium_impact	-0.02	medium_impact	0.34	medium_impact	0.28	0.8	19.61	16.67	0.44	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10895	10895	A	C	MI.16609	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	136	46	N	H	Aac/Cac	-20	0	0	probably_damaging	0.96	neutral	0.51	neutral	1.55	neutral	-1.55	neutral	-0.97	medium_impact	2.38	0.83	neutral	0.84	neutral	1.66	14.20	neutral	0.34	0.5	NA	NA	0.33	neutral	0.34	neutral	0.15	neutral	7	0.96	neutral	0.28	neutral	1	deleterious	0.65	deleterious	-2.01	low_impact	0.21	medium_impact	1.23	medium_impact	0.20	0.8	19.61	16.67	0.36	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8467	8467	C	G	MI.1661	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	102	34	H	Q	caC/caG	-4.04	0	0	probably_damaging	0.98	neutral	0.31	neutral	0.71	deleterious	-7.1	deleterious	-3.07	low_impact	1.81	1	neutral	0.63	neutral	2.31	18.21	deleterious	0.78924240	0.85	0.32	neutral	0.21	neutral	0.47	neutral	0.13	neutral	7	0.99	deleterious	0.17	neutral	-2	neutral	0.67	deleterious	-2.36	low_impact	0.1	medium_impact	0.45	medium_impact	0.51	0.85	10.29	8.62	0.51	N	0.18	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10896	10896	A	G	MI.16610	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	137	46	N	S	aAc/aGc	-4.78	0	0	benign	0.09	neutral	0.65	neutral	1.63	neutral	0.19	neutral	0.54	low_impact	1.18	0.76	neutral	0.99	neutral	-1.54	0.00	neutral	0.45	0.55	NA	NA	0.07	neutral	0.28	neutral	0.21	neutral	6	0.26	neutral	0.78	deleterious	-6	neutral	0.26	neutral	0.23	medium_impact	0.35	medium_impact	0.04	medium_impact	0.27	0.8	19.61	16.67	0.4	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10896	10896	A	C	MI.16611	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	137	46	N	T	aAc/aCc	-4.78	0	0	possibly_damaging	0.64	neutral	0.45	neutral	1.6	neutral	-0.33	neutral	-0.4	medium_impact	2.17	0.74	neutral	0.98	neutral	1.43	12.92	neutral	0.32	0.5	NA	NA	0.22	neutral	0.27	neutral	0.15	neutral	7	0.64	neutral	0.41	neutral	0	NA	0.40	neutral	-0.95	medium_impact	0.15	medium_impact	1.02	medium_impact	0.24	0.8	19.61	16.67	0.47	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10896	10896	A	T	MI.16612	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	137	46	N	I	aAc/aTc	-4.78	0	0	probably_damaging	0.93	neutral	0.39	neutral	1.55	neutral	-1.59	neutral	-1.79	medium_impact	2.17	0.83	neutral	0.81	neutral	2.62	20.30	deleterious	0.17	0.45	NA	NA	0.46	neutral	0.41	neutral	0.25	neutral	5	0.93	neutral	0.23	neutral	1	deleterious	0.63	deleterious	-1.77	low_impact	0.09	medium_impact	1.02	medium_impact	0.15	0.8	19.61	16.67	0.35	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10897	10897	C	A	MI.16613	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	138	46	N	K	aaC/aaA	-2.24	0	0	possibly_damaging	0.64	neutral	0.33	neutral	1.58	neutral	0.11	neutral	-0.94	medium_impact	2.38	0.79	neutral	0.56	neutral	2.49	19.42	deleterious	0.35	0.5	NA	NA	0.44	neutral	0.49	neutral	0.21	neutral	6	0.72	neutral	0.35	neutral	0	NA	0.40	neutral	-0.95	medium_impact	0.03	medium_impact	1.23	medium_impact	0.33	0.8	19.61	16.67	0.38	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10897	10897	C	G	MI.16614	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	138	46	N	K	aaC/aaG	-2.24	0	0	possibly_damaging	0.64	neutral	0.33	neutral	1.58	neutral	0.11	neutral	-0.94	medium_impact	2.38	0.79	neutral	0.56	neutral	2.01	16.29	deleterious	0.35	0.5	NA	NA	0.44	neutral	0.49	neutral	0.21	neutral	6	0.72	neutral	0.35	neutral	0	NA	0.40	neutral	-0.95	medium_impact	0.03	medium_impact	1.23	medium_impact	0.33	0.8	19.61	16.67	0.37	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10898	10898	A	G	MI.16615	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	139	47	N	D	Aac/Gac	-5.93	0	0	benign	0.25	neutral	0.21	neutral	1.58	neutral	-0.57	neutral	0.74	low_impact	1.14	0.76	neutral	0.98	neutral	-0.42	0.34	neutral	0.45	0.55	NA	NA	0.12	neutral	0.33	neutral	0.22	neutral	6	0.75	neutral	0.48	deleterious	-6	neutral	0.26	neutral	-0.27	medium_impact	-0.12	medium_impact	0	medium_impact	0.35	0.8	32.03	28.79	0.46	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10898	10898	A	C	MI.16616	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	139	47	N	H	Aac/Cac	-5.93	0	0	possibly_damaging	0.8	neutral	0.53	neutral	1.49	neutral	-1.7	neutral	-0.84	medium_impact	2.17	0.81	neutral	0.84	neutral	2.57	19.89	deleterious	0.32	0.5	NA	NA	0.28	neutral	0.52	disease	0.31	neutral	4	0.78	neutral	0.37	neutral	0	NA	0.61	deleterious	-1.28	low_impact	0.23	medium_impact	1.02	medium_impact	0.29	0.8	32.03	28.79	0.29	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10898	10898	A	T	MI.16617	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	139	47	N	Y	Aac/Tac	-5.93	0	0	possibly_damaging	0.85	neutral	1	neutral	1.49	neutral	-1.85	neutral	-1.2	low_impact	1.49	0.78	neutral	0.81	neutral	3.11	22.50	deleterious	0.12	0.4	NA	NA	0.3	neutral	0.32	neutral	0.14	neutral	7	0.85	neutral	0.58	deleterious	-3	neutral	0.62	deleterious	-1.43	low_impact	1.88	high_impact	0.35	medium_impact	0.35	0.8	32.03	28.79	0.22	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10899	10899	A	G	MI.16618	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	140	47	N	S	aAc/aGc	0.06	0	0	benign	0.03	neutral	0.41	neutral	1.59	neutral	0.33	neutral	-0.45	low_impact	1.21	0.73	neutral	0.86	neutral	-0.18	1.18	neutral	0.51	0.6	NA	NA	0.16	neutral	0.32	neutral	0.21	neutral	6	0.57	neutral	0.69	deleterious	-6	neutral	0.11	neutral	0.7	medium_impact	0.11	medium_impact	0.07	medium_impact	0.23	0.8	32.03	28.79	0.44	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10899	10899	A	T	MI.16619	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	140	47	N	I	aAc/aTc	0.06	0	0	benign	0.04	neutral	0.39	neutral	1.52	neutral	-0.96	neutral	-1.36	low_impact	1.83	0.81	neutral	0.89	neutral	2.41	18.91	deleterious	0.15	0.4	NA	NA	0.41	neutral	0.34	neutral	0.16	neutral	7	0.58	neutral	0.68	deleterious	-6	neutral	0.56	deleterious	0.58	medium_impact	0.09	medium_impact	0.68	medium_impact	0.19	0.8	32.03	28.79	0.37	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8467	8467	C	A	MI.1662	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	102	34	H	Q	caC/caA	-4.04	0	0	probably_damaging	0.98	neutral	0.31	neutral	0.71	deleterious	-7.1	deleterious	-3.07	low_impact	1.81	1	neutral	0.63	neutral	2.64	20.40	deleterious	0.78924240	0.85	0.32	neutral	0.21	neutral	0.47	neutral	0.13	neutral	7	0.99	deleterious	0.17	neutral	-2	neutral	0.67	deleterious	-2.36	low_impact	0.1	medium_impact	0.45	medium_impact	0.51	0.85	10.29	8.62	0.51	N	0.18	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10899	10899	A	C	MI.16620	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	140	47	N	T	aAc/aCc	0.06	0	0	benign	0.03	neutral	0.39	neutral	1.55	neutral	-0.21	neutral	-0.52	neutral_impact	-0.15	0.72	neutral	0.96	neutral	-0.05	2.13	deleterious	0.28	0.45	NA	NA	0.17	neutral	0.3	neutral	0.2	neutral	6	0.59	neutral	0.68	deleterious	-6	neutral	0.21	neutral	0.7	medium_impact	0.09	medium_impact	-1.27	low_impact	0.48	0.8	32.03	28.79	0.4	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10900	10900	C	A	MI.16621	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	141	47	N	K	aaC/aaA	1.21	0	0	benign	0.25	neutral	0.28	neutral	1.55	neutral	0.15	neutral	-0.83	low_impact	1.83	0.78	neutral	0.69	neutral	1.34	12.48	neutral	0.4	0.5	NA	NA	0.39	neutral	0.57	disease	0.36	neutral	3	0.66	neutral	0.52	deleterious	-6	neutral	0.32	neutral	-0.27	medium_impact	-0.03	medium_impact	0.68	medium_impact	0.44	0.8	32.03	28.79	0.37	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10900	10900	C	G	MI.16622	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	141	47	N	K	aaC/aaG	1.21	0	0	benign	0.25	neutral	0.28	neutral	1.55	neutral	0.15	neutral	-0.83	low_impact	1.83	0.78	neutral	0.69	neutral	0.86	9.82	deleterious	0.4	0.5	NA	NA	0.39	neutral	0.57	disease	0.36	neutral	3	0.66	neutral	0.52	deleterious	-6	neutral	0.32	neutral	-0.27	medium_impact	-0.03	medium_impact	0.68	medium_impact	0.44	0.8	32.03	28.79	0.37	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10901	10901	A	G	MI.16623	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	142	48	N	D	Aac/Gac	-5.24	0	0	possibly_damaging	0.52	neutral	0.2	neutral	1.56	neutral	-0.54	neutral	-1.28	medium_impact	2.13	0.83	neutral	0.55	neutral	0.57	7.94	deleterious	0.73	0.75	NA	NA	0.26	neutral	0.45	neutral	0.17	neutral	7	0.79	neutral	0.34	neutral	0	NA	0.35	neutral	-0.75	medium_impact	-0.14	medium_impact	0.98	medium_impact	0.33	0.8	29.85	20.94	0.42	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10901	10901	A	C	MI.16624	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	142	48	N	H	Aac/Cac	-5.24	0	0	probably_damaging	0.92	neutral	0.53	neutral	1.54	neutral	-1.34	neutral	-1.36	medium_impact	2.13	0.8	neutral	0.91	neutral	1.13	11.36	neutral	0.47	0.55	NA	NA	0.31	neutral	0.29	neutral	0.17	neutral	7	0.91	neutral	0.31	neutral	1	deleterious	0.63	deleterious	-1.71	low_impact	0.23	medium_impact	0.98	medium_impact	0.15	0.8	29.85	20.94	0.3	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10901	10901	A	T	MI.16625	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	142	48	N	Y	Aac/Tac	-5.24	0	0	probably_damaging	0.94	neutral	1	neutral	1.58	neutral	-2.19	neutral	-1.56	low_impact	1.79	0.78	neutral	0.66	neutral	1.40	12.77	neutral	0.13	0.4	NA	NA	0.39	neutral	0.24	neutral	0.17	neutral	7	0.94	neutral	0.53	deleterious	-2	neutral	0.67	deleterious	-1.84	low_impact	1.88	high_impact	0.65	medium_impact	0.16	0.8	29.85	20.94	0.22	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10902	10902	A	C	MI.16626	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	143	48	N	T	aAc/aCc	-0.4	0	0	possibly_damaging	0.52	neutral	0.43	neutral	1.58	neutral	-0.21	neutral	0.24	low_impact	1.88	0.69	neutral	0.98	neutral	-0.85	0.03	neutral	0.39	0.5	NA	NA	0.11	neutral	0.19	neutral	0.24	neutral	5	0.57	neutral	0.46	neutral	-3	neutral	0.27	neutral	-0.75	medium_impact	0.13	medium_impact	0.73	medium_impact	0.25	0.8	29.85	20.94	0.59	P	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10902	10902	A	T	MI.16627	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	143	48	N	I	aAc/aTc	-0.4	0	0	possibly_damaging	0.89	neutral	0.4	neutral	1.54	neutral	-2.03	neutral	-1.59	medium_impact	2	0.77	neutral	0.83	neutral	2.51	19.52	deleterious	0.15	0.4	NA	NA	0.45	neutral	0.4	neutral	0.19	neutral	6	0.89	neutral	0.26	neutral	0	NA	0.60	deleterious	-1.57	low_impact	0.1	medium_impact	0.85	medium_impact	0.11	0.8	29.85	20.94	0.38	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10902	10902	A	G	MI.16628	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	143	48	N	S	aAc/aGc	-0.4	0	0	benign	0.05	neutral	0.43	neutral	1.65	neutral	0.08	neutral	-0.41	low_impact	1.19	0.76	neutral	0.97	neutral	0.08	3.36	deleterious	0.61	0.65	NA	NA	0.21	neutral	0.24	neutral	0.18	neutral	6	0.53	neutral	0.69	deleterious	-6	neutral	0.12	neutral	0.48	medium_impact	0.13	medium_impact	0.05	medium_impact	0.20	0.8	29.85	20.94	0.45	N	0.55	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10903	10903	C	A	MI.16629	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	144	48	N	K	aaC/aaA	-1.78	0	0	possibly_damaging	0.52	neutral	0.28	neutral	1.61	neutral	0.18	neutral	-1.32	medium_impact	2.68	0.8	neutral	0.54	neutral	1.30	12.25	neutral	0.56	0.6	NA	NA	0.43	neutral	0.46	neutral	0.18	neutral	6	0.7	neutral	0.38	neutral	0	NA	0.40	neutral	-0.75	medium_impact	-0.03	medium_impact	1.53	medium_impact	0.42	0.8	29.85	20.94	0.39	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8468	8468	C	A	MI.1663	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	103	35	L	M	Cta/Ata	-3.8	0	0	probably_damaging	1	neutral	0.27	neutral	1.54	neutral	-1.13	neutral	-0.12	low_impact	1.14	1	neutral	0.75	neutral	2.50	19.50	deleterious	0.52090386	0.85	0.39	neutral	0.07	neutral	0.22	neutral	0.06	neutral	9	1	deleterious	0.14	neutral	-2	neutral	0.65	deleterious	-3.6	low_impact	0.05	medium_impact	-0.12	medium_impact	0.61	0.85	19.12	9.43	0.57	P	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10903	10903	C	G	MI.16630	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	144	48	N	K	aaC/aaG	-1.78	0	0	possibly_damaging	0.52	neutral	0.28	neutral	1.61	neutral	0.18	neutral	-1.32	medium_impact	2.68	0.8	neutral	0.54	neutral	0.82	9.59	deleterious	0.56	0.6	NA	NA	0.43	neutral	0.46	neutral	0.18	neutral	6	0.7	neutral	0.38	neutral	0	NA	0.40	neutral	-0.75	medium_impact	-0.03	medium_impact	1.53	medium_impact	0.42	0.8	29.85	20.94	0.39	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10904	10904	C	A	MI.16631	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	145	49	L	M	Cta/Ata	-8.24	0	0	probably_damaging	0.98	neutral	0.23	neutral	1.48	neutral	-1.12	neutral	0.52	neutral_impact	0.7	0.76	neutral	0.84	neutral	2.54	19.73	deleterious	0.26	0.45	NA	NA	0.05	neutral	0.18	neutral	0.2	neutral	6	0.99	deleterious	0.13	neutral	-2	neutral	0.66	deleterious	-2.31	low_impact	-0.09	medium_impact	-0.43	medium_impact	0.39	0.8	32.9	33.04	0.56	P	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10904	10904	C	G	MI.16632	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	145	49	L	V	Cta/Gta	-8.24	0	0	possibly_damaging	0.86	neutral	0.5	neutral	1.51	neutral	-0.73	neutral	-0.09	low_impact	1.67	0.8	neutral	0.8	neutral	1.96	15.95	deleterious	0.3	0.45	NA	NA	0.12	neutral	0.3	neutral	0.23	neutral	6	0.84	neutral	0.32	neutral	-3	neutral	0.67	deleterious	-1.46	low_impact	0.2	medium_impact	0.53	medium_impact	0.31	0.8	32.9	33.04	0.35	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10905	10905	T	C	MI.16633	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	146	49	L	P	cTa/cCa	-0.86	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.42	neutral	-2.5	neutral	0.32	low_impact	1.67	0.74	neutral	0.85	neutral	2.45	19.14	deleterious	0.09	0.35	NA	NA	0.55	disease	0.37	neutral	0.47	neutral	1	0.99	deleterious	0.11	neutral	-2	neutral	0.78	deleterious	-2.59	low_impact	-0.14	medium_impact	0.53	medium_impact	0.16	0.8	32.9	33.04	0.46	N	0.71	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10905	10905	T	A	MI.16634	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	146	49	L	Q	cTa/cAa	-0.86	0	0	probably_damaging	0.99	neutral	0.29	neutral	1.42	neutral	-2.63	neutral	0.7	low_impact	1.67	0.79	neutral	0.75	neutral	2.79	21.30	deleterious	0.12	0.4	NA	NA	0.34	neutral	0.35	neutral	0.15	neutral	7	0.99	deleterious	0.15	neutral	-2	neutral	0.72	deleterious	-2.59	low_impact	-0.02	medium_impact	0.53	medium_impact	0.14	0.8	32.9	33.04	0.41	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10905	10905	T	G	MI.16635	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	146	49	L	R	cTa/cGa	-0.86	0	0	probably_damaging	0.98	neutral	0.34	neutral	1.42	neutral	-2.78	neutral	0.28	low_impact	1.67	0.7	neutral	0.52	neutral	2.88	21.80	deleterious	0.09	0.35	NA	NA	0.51	disease	0.49	neutral	0.52	disease	0	0.99	deleterious	0.18	neutral	-2	neutral	0.76	deleterious	-2.31	low_impact	0.04	medium_impact	0.53	medium_impact	0.14	0.8	32.9	33.04	0.44	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10907	10907	T	A	MI.16636	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	148	50	F	I	Ttt/Att	-8.01	0	0.01	benign	0	neutral	0.41	neutral	1.58	neutral	-1.04	neutral	-0.14	neutral_impact	-0.34	0.79	neutral	0.88	neutral	0.98	10.54	neutral	0.24	0.45	NA	NA	0.15	neutral	0.48	neutral	0.22	neutral	6	0.59	neutral	0.71	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	0.11	medium_impact	-1.46	low_impact	0.50	0.8	33.33	26.24	0.36	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10907	10907	T	G	MI.16637	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	148	50	F	V	Ttt/Gtt	-8.01	0	0.01	benign	0.03	neutral	0.51	neutral	1.61	neutral	-0.98	neutral	-0.39	neutral_impact	0	0.82	neutral	0.77	neutral	0.61	8.24	deleterious	0.11	0.4	NA	NA	0.17	neutral	0.49	neutral	0.21	neutral	6	0.46	neutral	0.74	deleterious	-6	neutral	0.09	neutral	0.7	medium_impact	0.21	medium_impact	-1.13	low_impact	0.29	0.8	33.33	26.24	0.32	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10907	10907	T	C	MI.16638	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	148	50	F	L	Ttt/Ctt	-8.01	0	0.01	benign	0	neutral	0.7	neutral	1.64	neutral	-0.54	neutral	0.57	neutral_impact	-2.1	0.78	neutral	0.98	neutral	-0.45	0.30	neutral	0.27	0.45	NA	NA	0.09	neutral	0.26	neutral	0.2	neutral	6	0.29	neutral	0.85	deleterious	-6	neutral	0.07	neutral	2.1	high_impact	0.41	medium_impact	-3.2	low_impact	0.52	0.8	33.33	26.24	0.35	N	0.01	polymorphism	1	0.00	rs879094052	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10908	10908	T	C	MI.16639	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	149	50	F	S	tTt/tCt	-0.63	0	0	benign	0.01	neutral	0.47	neutral	1.71	neutral	-2.13	neutral	-0.79	neutral_impact	-1.79	0.71	neutral	0.92	neutral	0.93	10.25	neutral	0.05	0.35	NA	NA	0.19	neutral	0.53	disease	0.28	neutral	4	0.52	neutral	0.73	deleterious	-6	neutral	0.11	neutral	1.16	medium_impact	0.17	medium_impact	-2.9	low_impact	0.17	0.8	33.33	26.24	0.33	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8468	8468	C	G	MI.1664	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	103	35	L	V	Cta/Gta	-3.8	0	0	probably_damaging	0.97	neutral	0.6	neutral	1.56	neutral	-0.51	neutral	-0.75	low_impact	1.68	1	neutral	0.74	neutral	1.48	13.22	neutral	0.49944063	0.85	0.24	neutral	0.08	neutral	0.31	neutral	0.05	neutral	9	0.97	neutral	0.32	neutral	-2	neutral	0.62	deleterious	-2.19	low_impact	0.39	medium_impact	0.34	medium_impact	0.52	0.85	19.12	9.43	0.38	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10908	10908	T	G	MI.16640	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	149	50	F	C	tTt/tGt	-0.63	0	0	benign	0.01	neutral	0.19	neutral	1.57	deleterious	-3.72	neutral	-1.08	neutral_impact	0.34	0.77	neutral	0.63	neutral	1.14	11.45	neutral	0.07	0.35	NA	NA	0.41	neutral	0.36	neutral	0.15	neutral	7	0.81	neutral	0.59	deleterious	-6	neutral	0.43	deleterious	1.16	medium_impact	-0.15	medium_impact	-0.79	medium_impact	0.21	0.8	33.33	26.24	0.39	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10908	10908	T	A	MI.16641	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	149	50	F	Y	tTt/tAt	-0.63	0	0	benign	0.01	neutral	1	neutral	1.59	neutral	-2.01	neutral	0.33	neutral_impact	0	0.73	neutral	0.96	neutral	0.51	7.53	deleterious	0.2	0.45	NA	NA	0.11	neutral	0.28	neutral	0.21	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.16	medium_impact	1.88	high_impact	-1.13	low_impact	0.54	0.8	33.33	26.24	0.32	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10909	10909	T	A	MI.16642	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	150	50	F	L	ttT/ttA	-0.17	0	0	benign	0	neutral	0.7	neutral	1.64	neutral	-0.54	neutral	0.57	neutral_impact	-2.1	0.78	neutral	0.98	neutral	0.06	3.18	deleterious	0.27	0.45	NA	NA	0.09	neutral	0.26	neutral	0.2	neutral	6	0.29	neutral	0.85	deleterious	-6	neutral	0.07	neutral	2.1	high_impact	0.41	medium_impact	-3.2	low_impact	0.52	0.8	33.33	26.24	0.36	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10909	10909	T	G	MI.16643	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	150	50	F	L	ttT/ttG	-0.17	0	0	benign	0	neutral	0.7	neutral	1.64	neutral	-0.54	neutral	0.57	neutral_impact	-2.1	0.78	neutral	0.98	neutral	0.02	2.77	deleterious	0.27	0.45	NA	NA	0.09	neutral	0.26	neutral	0.2	neutral	6	0.29	neutral	0.85	deleterious	-6	neutral	0.07	neutral	2.1	high_impact	0.41	medium_impact	-3.2	low_impact	0.52	0.8	33.33	26.24	0.35	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10910	10910	A	T	MI.16644	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	151	51	S	C	Agc/Tgc	-2.94	0	0	possibly_damaging	0.84	neutral	0.17	neutral	1.49	deleterious	-4.49	neutral	-2.25	low_impact	0.98	0.8	neutral	0.46	neutral	1.76	14.73	neutral	0.14	0.4	NA	NA	0.45	neutral	0.49	neutral	0.26	neutral	5	0.92	neutral	0.17	neutral	-3	neutral	0.57	deleterious	-1.39	low_impact	-0.18	medium_impact	-0.16	medium_impact	0.17	0.8	18.95	19.87	0.35	N	0.72	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10910	10910	A	C	MI.16645	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	151	51	S	R	Agc/Cgc	-2.94	0	0	benign	0.34	neutral	0.34	neutral	1.5	neutral	-1.15	neutral	-1.24	low_impact	1.52	0.73	neutral	0.46	neutral	0.71	8.92	deleterious	0.13	0.4	NA	NA	0.45	neutral	0.64	disease	0.44	neutral	1	0.59	neutral	0.5	deleterious	-6	neutral	0.34	neutral	-0.45	medium_impact	0.04	medium_impact	0.38	medium_impact	0.31	0.8	18.95	19.87	0.34	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10910	10910	A	G	MI.16646	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	151	51	S	G	Agc/Ggc	-2.94	0	0	benign	0.01	neutral	0.34	neutral	1.51	neutral	-1.03	neutral	-0.97	low_impact	0.83	0.81	neutral	0.81	neutral	0.35	6.15	deleterious	0.3	0.45	NA	NA	0.17	neutral	0.44	neutral	0.24	neutral	5	0.65	neutral	0.67	deleterious	-6	neutral	0.21	neutral	1.16	medium_impact	0.04	medium_impact	-0.31	medium_impact	0.44	0.8	18.95	19.87	0.4	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10911	10911	G	C	MI.16647	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	152	51	S	T	aGc/aCc	1.44	0	0	benign	0.01	neutral	0.44	neutral	1.55	neutral	-0.88	neutral	-0.5	neutral_impact	0.2	0.82	neutral	0.95	neutral	-0.51	0.21	neutral	0.42	0.55	NA	NA	0.12	neutral	0.23	neutral	0.23	neutral	5	0.55	neutral	0.72	deleterious	-6	neutral	0.11	neutral	1.16	medium_impact	0.14	medium_impact	-0.93	medium_impact	0.42	0.8	18.95	19.87	0.41	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10911	10911	G	A	MI.16648	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	152	51	S	N	aGc/aAc	1.44	0	0	benign	0.01	neutral	0.44	neutral	1.59	neutral	-0.81	neutral	1.58	neutral_impact	-1.04	0.8	neutral	0.97	neutral	-1.21	0.01	neutral	0.7	0.75	NA	NA	0.09	neutral	0.26	neutral	0.22	neutral	6	0.55	neutral	0.72	deleterious	-6	neutral	0.19	neutral	1.16	medium_impact	0.14	medium_impact	-2.16	low_impact	0.47	0.8	18.95	19.87	0.36	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	COSM488728	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10911	10911	G	T	MI.16649	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	152	51	S	I	aGc/aTc	1.44	0	0	benign	0.01	neutral	0.42	neutral	1.5	neutral	-2.42	neutral	-2.11	low_impact	1.52	0.81	neutral	0.89	neutral	0.83	9.65	deleterious	0.13	0.4	NA	NA	0.43	neutral	0.48	neutral	0.2	neutral	6	0.57	neutral	0.71	deleterious	-6	neutral	0.15	neutral	1.16	medium_impact	0.12	medium_impact	0.38	medium_impact	0.26	0.8	18.95	19.87	0.37	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8469	8469	T	C	MI.1665	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	104	35	L	P	cTa/cCa	-4.27	0	0	probably_damaging	1	neutral	0.33	neutral	1.54	neutral	-1.12	neutral	-0.94	neutral_impact	-0.16	1	neutral	0.9	neutral	2.51	19.51	deleterious	0.46155204	0.85	0.48	neutral	0.15	neutral	0.26	neutral	0.07	neutral	9	1	deleterious	0.17	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.12	medium_impact	-1.24	low_impact	0.56	0.85	19.12	9.43	0.51	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10913	10913	T	G	MI.16650	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	154	52	C	G	Tgt/Ggt	-3.17	0	0	benign	0.05	neutral	0.25	neutral	1.58	neutral	-0.03	neutral	-1.09	neutral_impact	0	0.81	neutral	0.62	neutral	0.07	3.33	deleterious	0.1	0.4	NA	NA	0.14	neutral	0.44	neutral	0.23	neutral	5	0.73	neutral	0.6	deleterious	-6	neutral	0.12	neutral	0.48	medium_impact	-0.07	medium_impact	-1.13	low_impact	0.23	0.8	23.09	23.28	0.38	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10913	10913	T	C	MI.16651	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	154	52	C	R	Tgt/Cgt	-3.17	0	0	benign	0.06	neutral	0.08	neutral	1.59	neutral	0.06	neutral	-0.74	neutral_impact	0	0.77	neutral	0.55	neutral	0.24	5.08	deleterious	0.06	0.35	NA	NA	0.26	neutral	0.57	disease	0.37	neutral	3	0.91	neutral	0.51	deleterious	-6	neutral	0.14	neutral	0.41	medium_impact	-0.39	medium_impact	-1.13	low_impact	0.06	0.8	23.09	23.28	0.37	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10913	10913	T	A	MI.16652	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	154	52	C	S	Tgt/Agt	-3.17	0	0	benign	0.04	neutral	0.26	neutral	1.7	neutral	2.51	neutral	0.19	neutral_impact	-1.84	0.76	neutral	0.96	neutral	-0.31	0.64	neutral	0.12	0.4	NA	NA	0.08	neutral	0.26	neutral	0.21	neutral	6	0.72	neutral	0.61	deleterious	-6	neutral	0.11	neutral	0.58	medium_impact	-0.05	medium_impact	-2.95	low_impact	0.39	0.8	23.09	23.28	0.45	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10914	10914	G	C	MI.16653	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	155	52	C	S	tGt/tCt	-1.09	0	0	benign	0.04	neutral	0.26	neutral	1.7	neutral	2.51	neutral	0.19	neutral_impact	-1.84	0.76	neutral	0.96	neutral	-0.63	0.11	neutral	0.12	0.4	NA	NA	0.08	neutral	0.26	neutral	0.21	neutral	6	0.72	neutral	0.61	deleterious	-6	neutral	0.11	neutral	0.58	medium_impact	-0.05	medium_impact	-2.95	low_impact	0.39	0.8	23.09	23.28	0.46	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10914	10914	G	A	MI.16654	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	155	52	C	Y	tGt/tAt	-1.09	0	0	benign	0	neutral	0.27	neutral	1.6	neutral	0.54	neutral	1.44	neutral_impact	-0.55	0.84	neutral	0.98	neutral	-0.70	0.07	neutral	0.1	0.4	NA	NA	0.16	neutral	0.23	neutral	0.22	neutral	6	0.73	neutral	0.64	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	-0.04	medium_impact	-1.67	low_impact	0.22	0.8	23.09	23.28	0.39	N	0.00	polymorphism	1	0.01	rs878931758	.	.	.	.	.	COSM6716742	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10914	10914	G	T	MI.16655	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	155	52	C	F	tGt/tTt	-1.09	0	0	benign	0	neutral	0.38	neutral	1.64	neutral	1.69	neutral	2.22	neutral_impact	-2.46	0.74	neutral	0.97	neutral	-0.92	0.02	neutral	0.11	0.4	NA	NA	0.15	neutral	0.19	neutral	0.22	neutral	6	0.62	neutral	0.69	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	0.08	medium_impact	-3.56	low_impact	0.23	0.8	23.09	23.28	0.46	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10915	10915	T	G	MI.16656	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	156	52	C	W	tgT/tgG	-0.17	0	0.04	benign	0.32	deleterious	0.04	neutral	1.57	neutral	-1.29	neutral	0.37	neutral_impact	0	0.83	neutral	0.63	neutral	2.10	16.83	deleterious	0.08	0.35	NA	NA	0.22	neutral	0.47	neutral	0.16	neutral	7	0.95	neutral	0.36	neutral	-2	neutral	0.21	neutral	-0.41	medium_impact	-0.57	medium_impact	-1.13	low_impact	0.33	0.8	23.09	23.28	0.44	N	0.30	polymorphism	1	0.01	rs2857285	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10915	10915	T	A	MI.16657	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	156	52	C	W	tgT/tgA	-0.17	0	0.04	benign	0.32	deleterious	0.04	neutral	1.57	neutral	-1.29	neutral	0.37	neutral_impact	0	0.83	neutral	0.63	neutral	2.25	17.81	deleterious	0.08	0.35	NA	NA	0.22	neutral	0.47	neutral	0.16	neutral	7	0.95	neutral	0.36	neutral	-2	neutral	0.21	neutral	-0.41	medium_impact	-0.57	medium_impact	-1.13	low_impact	0.33	0.8	23.09	23.28	0.44	N	0.30	polymorphism	1	0.01	rs2857285	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10916	10916	T	C	MI.16658	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	157	53	S	P	Tcc/Ccc	-8.01	0	0	probably_damaging	1	neutral	0.06	neutral	1.32	deleterious	-3.52	deleterious	-3.13	medium_impact	2.98	0.71	neutral	0.15	damaging	3.76	23.40	deleterious	0.07	0.35	NA	NA	0.69	disease	0.45	neutral	0.52	disease	0	1	deleterious	0.03	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.47	medium_impact	1.82	medium_impact	0.19	0.8	16.34	17.29	0.35	N	0.96	polymorphism	1	0.08	rs879188757	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10916	10916	T	A	MI.16659	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	157	53	S	T	Tcc/Acc	-8.01	0	0	probably_damaging	1	neutral	0.31	neutral	1.4	neutral	-1.56	neutral	-1.77	low_impact	1.66	0.76	neutral	0.24	damaging	2.49	19.43	deleterious	0.22	0.45	NA	NA	0.22	neutral	0.23	neutral	0.2	neutral	6	1	deleterious	0.16	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.01	medium_impact	0.52	medium_impact	0.52	0.8	16.34	17.29	0.39	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8469	8469	T	G	MI.1666	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	104	35	L	R	cTa/cGa	-4.27	0	0	probably_damaging	1	neutral	0.52	neutral	1.56	neutral	-0.65	neutral	-1.64	low_impact	1.34	0.99	neutral	0.5	neutral	2.57	19.92	deleterious	0.36236553	0.85	0.31	neutral	0.36	neutral	0.44	neutral	0.16	neutral	7	0.99	deleterious	0.26	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.31	medium_impact	0.05	medium_impact	0.45	0.85	19.12	9.43	0.39	N	0.29	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10916	10916	T	G	MI.16660	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	157	53	S	A	Tcc/Gcc	-8.01	0	0	probably_damaging	1	deleterious	0.04	neutral	1.38	neutral	-1.83	neutral	-2.01	medium_impact	2.63	0.73	neutral	0.19	damaging	3.46	23.00	deleterious	0.24	0.45	NA	NA	0.23	neutral	0.42	neutral	0.19	neutral	6	1	deleterious	0.02	neutral	5	deleterious	0.71	deleterious	-3.54	low_impact	-0.57	medium_impact	1.48	medium_impact	0.37	0.8	16.34	17.29	0.39	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10917	10917	C	G	MI.16661	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	158	53	S	C	tCc/tGc	0.29	0	0	probably_damaging	1	neutral	0.07	neutral	1.3	deleterious	-4.77	deleterious	-3.21	medium_impact	2.98	0.74	neutral	0.09	damaging	3.43	23.00	deleterious	0.08	0.35	NA	NA	0.61	disease	0.47	neutral	0.51	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.43	medium_impact	1.82	medium_impact	0.28	0.8	16.34	17.29	0.32	N	0.63	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10917	10917	C	A	MI.16662	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	158	53	S	Y	tCc/tAc	0.29	0	0	probably_damaging	1	neutral	0.15	neutral	1.31	deleterious	-3.82	deleterious	-3.51	medium_impact	2.98	0.75	neutral	0.09	damaging	3.87	23.50	deleterious	0.08	0.35	NA	NA	0.58	disease	0.45	neutral	0.54	disease	1	1	deleterious	0.08	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.22	medium_impact	1.82	medium_impact	0.28	0.8	16.34	17.29	0.33	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10917	10917	C	T	MI.16663	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	158	53	S	F	tCc/tTc	0.29	0	0	probably_damaging	1	neutral	0.17	neutral	1.31	deleterious	-3.88	deleterious	-3.61	medium_impact	2.98	0.73	neutral	0.1	damaging	4.10	23.70	deleterious	0.09	0.35	NA	NA	0.62	disease	0.49	neutral	0.5	neutral	0	1	deleterious	0.09	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.18	medium_impact	1.82	medium_impact	0.07	0.8	16.34	17.29	0.32	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10919	10919	C	T	MI.16664	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	160	54	P	S	Cca/Tca	-5.47	0	0	benign	0.02	neutral	0.42	neutral	1.65	neutral	1.21	neutral	0.64	low_impact	0.9	0.74	neutral	0.92	neutral	-0.01	2.47	deleterious	0.18	0.45	NA	NA	0.11	neutral	0.14	neutral	0.25	neutral	5	0.56	neutral	0.7	deleterious	-6	neutral	0.15	neutral	0.87	medium_impact	0.12	medium_impact	-0.24	medium_impact	0.12	0.8	33.33	23.33	0.54	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10919	10919	C	A	MI.16665	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	160	54	P	T	Cca/Aca	-5.47	0	0	benign	0	neutral	0.37	neutral	1.64	neutral	1	neutral	0.9	neutral_impact	0.02	0.81	neutral	0.98	neutral	-0.20	1.12	neutral	0.16	0.45	NA	NA	0.09	neutral	0.15	neutral	0.23	neutral	5	0.63	neutral	0.69	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	0.07	medium_impact	-1.11	low_impact	0.53	0.8	33.33	23.33	0.49	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10919	10919	C	G	MI.16666	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	160	54	P	A	Cca/Gca	-5.47	0	0	benign	0	neutral	0.47	neutral	1.63	neutral	0.9	neutral	0.14	low_impact	1.15	0.8	neutral	0.81	neutral	-1.04	0.01	neutral	0.17	0.45	NA	NA	0.06	neutral	0.45	neutral	0.19	neutral	6	0.53	neutral	0.74	deleterious	-6	neutral	0.08	neutral	2.1	high_impact	0.17	medium_impact	0.01	medium_impact	0.53	0.8	33.33	23.33	0.41	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10920	10920	C	G	MI.16667	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	161	54	P	R	cCa/cGa	-7.32	0	0	benign	0.05	neutral	0.32	neutral	1.59	neutral	0.05	neutral	-0.04	low_impact	1.7	0.8	neutral	0.46	neutral	-0.07	1.99	neutral	0.1	0.4	NA	NA	0.23	neutral	0.64	disease	0.38	neutral	3	0.65	neutral	0.64	deleterious	-6	neutral	0.26	neutral	0.48	medium_impact	0.02	medium_impact	0.56	medium_impact	0.28	0.8	33.33	23.33	0.37	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10920	10920	C	A	MI.16668	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	161	54	P	Q	cCa/cAa	-7.32	0	0	benign	0.11	neutral	0.28	neutral	1.61	neutral	0.66	neutral	0.19	low_impact	1.24	0.76	neutral	0.77	neutral	0.62	8.29	deleterious	0.12	0.4	NA	NA	0.15	neutral	0.5	neutral	0.22	neutral	6	0.68	neutral	0.59	deleterious	-6	neutral	0.36	neutral	0.14	medium_impact	-0.03	medium_impact	0.1	medium_impact	0.36	0.8	33.33	23.33	0.44	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10920	10920	C	T	MI.16669	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	161	54	P	L	cCa/cTa	-7.32	0	0	benign	0	neutral	0.64	neutral	1.66	neutral	1.35	neutral	0.92	neutral_impact	-0.5	0.81	neutral	0.96	neutral	-0.07	1.96	neutral	0.13	0.4	NA	NA	0.11	neutral	0.38	neutral	0.24	neutral	5	0.36	neutral	0.82	deleterious	-6	neutral	0.08	neutral	2.1	high_impact	0.34	medium_impact	-1.62	low_impact	0.72	0.85	33.33	23.33	0.35	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8469	8469	T	A	MI.1667	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	104	35	L	Q	cTa/cAa	-4.27	0	0	probably_damaging	1	neutral	0.5	neutral	1.55	neutral	-0.96	neutral	-1.1	neutral_impact	0.61	1	neutral	0.89	neutral	2.54	19.75	deleterious	0.31439318	0.85	0.3	neutral	0.15	neutral	0.25	neutral	0.07	neutral	9	0.99	deleterious	0.25	neutral	-2	neutral	0.66	deleterious	-3.6	low_impact	0.29	medium_impact	-0.58	medium_impact	0.54	0.85	19.12	9.43	0.44	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10922	10922	A	C	MI.16670	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	163	55	T	P	Acc/Ccc	-6.4	0	0	benign	0.11	neutral	0.06	neutral	1.52	neutral	-2.3	neutral	-1.99	low_impact	1.32	0.74	neutral	0.37	neutral	0.78	9.36	deleterious	0.05	0.35	NA	NA	0.33	neutral	0.26	neutral	0.16	neutral	7	0.93	neutral	0.48	deleterious	-6	neutral	0.18	neutral	0.14	medium_impact	-0.47	medium_impact	0.18	medium_impact	0.32	0.8	25.05	18.84	0.42	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10922	10922	A	T	MI.16671	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	163	55	T	S	Acc/Tcc	-6.4	0	0	benign	0	neutral	0.24	neutral	1.59	neutral	0.05	neutral	-0.76	neutral_impact	0.34	0.78	neutral	0.97	neutral	-0.09	1.80	neutral	0.31	0.45	NA	NA	0.06	neutral	0.25	neutral	0.19	neutral	6	0.76	neutral	0.62	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	-0.08	medium_impact	-0.79	medium_impact	0.55	0.8	25.05	18.84	0.48	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10922	10922	A	G	MI.16672	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	163	55	T	A	Acc/Gcc	-6.4	0	0	benign	0.01	neutral	0.25	neutral	1.61	neutral	0.32	neutral	-1.04	low_impact	1.32	0.79	neutral	0.86	neutral	0.38	6.45	deleterious	0.24	0.45	NA	NA	0.06	neutral	0.4	neutral	0.19	neutral	6	0.74	neutral	0.62	deleterious	-6	neutral	0.08	neutral	1.16	medium_impact	-0.07	medium_impact	0.18	medium_impact	0.40	0.8	25.05	18.84	0.49	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10923	10923	C	G	MI.16673	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	164	55	T	S	aCc/aGc	-2.71	0	0	benign	0	neutral	0.24	neutral	1.59	neutral	0.05	neutral	-0.76	neutral_impact	0.34	0.78	neutral	0.97	neutral	-0.48	0.25	neutral	0.31	0.45	NA	NA	0.06	neutral	0.25	neutral	0.19	neutral	6	0.76	neutral	0.62	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	-0.08	medium_impact	-0.79	medium_impact	0.55	0.8	25.05	18.84	0.5	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10923	10923	C	A	MI.16674	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	164	55	T	N	aCc/aAc	-2.71	0	0	benign	0	neutral	0.19	neutral	1.56	neutral	-0.42	neutral	-1.28	neutral_impact	0.77	0.72	neutral	0.93	neutral	0.31	5.76	deleterious	0.26	0.45	NA	NA	0.14	neutral	0.28	neutral	0.25	neutral	5	0.81	neutral	0.6	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	-0.15	medium_impact	-0.36	medium_impact	0.60	0.8	25.05	18.84	0.52	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10923	10923	C	T	MI.16675	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	164	55	T	I	aCc/aTc	-2.71	0	0	benign	0.02	neutral	0.43	neutral	1.61	neutral	0.4	neutral	-0.55	neutral_impact	0.42	0.79	neutral	0.96	neutral	0.37	6.31	deleterious	0.12	0.4	NA	NA	0.11	neutral	0.45	neutral	0.25	neutral	5	0.55	neutral	0.71	deleterious	-6	neutral	0.10	neutral	0.87	medium_impact	0.13	medium_impact	-0.71	medium_impact	0.66	0.8	25.05	18.84	0.36	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10925	10925	T	C	MI.16676	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	166	56	F	L	Ttt/Ctt	-2.71	0	0	benign	0.01	neutral	0.64	neutral	1.72	neutral	-0.79	neutral	-2.48	neutral_impact	0.64	0.75	neutral	0.82	neutral	1.97	16.04	deleterious	0.17	0.45	NA	NA	0.14	neutral	0.31	neutral	0.23	neutral	5	0.33	neutral	0.82	deleterious	-6	neutral	0.68	deleterious	1.16	medium_impact	0.34	medium_impact	-0.49	medium_impact	0.71	0.85	21.57	25.24	0.33	N	0.43	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10925	10925	T	A	MI.16677	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	166	56	F	I	Ttt/Att	-2.71	0	0	benign	0.25	deleterious	0.04	neutral	1.47	neutral	-1.76	deleterious	-2.86	medium_impact	2.58	0.77	neutral	0.56	neutral	4.20	23.90	deleterious	0.1	0.4	NA	NA	0.29	neutral	0.41	neutral	0.19	neutral	6	0.95	neutral	0.4	neutral	1	deleterious	0.71	deleterious	-0.27	medium_impact	-0.57	medium_impact	1.43	medium_impact	0.58	0.8	21.57	25.24	0.46	N	0.84	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10925	10925	T	G	MI.16678	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	166	56	F	V	Ttt/Gtt	-2.71	0	0	benign	0.36	neutral	0.07	neutral	1.48	neutral	-1.8	deleterious	-3.47	medium_impact	2.93	0.76	neutral	0.55	neutral	3.87	23.50	deleterious	0.06	0.35	NA	NA	0.36	neutral	0.59	disease	0.37	neutral	3	0.92	neutral	0.36	neutral	-3	neutral	0.71	deleterious	-0.48	medium_impact	-0.43	medium_impact	1.77	medium_impact	0.43	0.8	21.57	25.24	0.44	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10926	10926	T	C	MI.16679	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	167	56	F	S	tTt/tCt	1.21	0	0	possibly_damaging	0.81	deleterious	0.02	neutral	1.43	deleterious	-3.09	deleterious	-4.49	medium_impact	2.23	0.8	neutral	0.69	neutral	2.87	21.70	deleterious	0.02	0.35	NA	NA	0.45	neutral	0.61	disease	0.43	neutral	1	0.99	deleterious	0.11	neutral	4	deleterious	0.74	deleterious	-1.31	low_impact	-0.75	medium_impact	1.08	medium_impact	0.28	0.8	21.57	25.24	0.43	N	0.95	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8471	8471	C	T	MI.1668	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	106	36	P	S	Cct/Tct	-2.42	0	0	benign	0.02	neutral	0.72	neutral	2.03	neutral	0.4	neutral	-0.12	low_impact	0.98	1	neutral	0.96	neutral	-0.07	1.93	neutral	0.45913084	0.85	0.14	neutral	0.06	neutral	0.31	neutral	0.04	neutral	9	0.24	neutral	0.85	deleterious	-6	neutral	0.12	neutral	0.85	medium_impact	0.52	medium_impact	-0.26	medium_impact	0.23	0.85	19.12	8.87	0.43	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10926	10926	T	A	MI.16680	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	167	56	F	Y	tTt/tAt	1.21	0	0	benign	0.03	neutral	0.08	neutral	1.42	neutral	-2.75	neutral	-1.09	medium_impact	2.58	0.74	neutral	0.76	neutral	2.20	17.52	deleterious	0.12	0.4	NA	NA	0.15	neutral	0.28	neutral	0.17	neutral	7	0.92	neutral	0.53	deleterious	-3	neutral	0.70	deleterious	0.7	medium_impact	-0.39	medium_impact	1.43	medium_impact	0.56	0.8	21.57	25.24	0.56	P	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10926	10926	T	G	MI.16681	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	167	56	F	C	tTt/tGt	1.21	0	0	probably_damaging	0.95	deleterious	0.01	neutral	1.38	deleterious	-4.63	deleterious	-4.43	medium_impact	2.93	0.8	neutral	0.41	neutral	3.89	23.50	deleterious	0.03	0.35	NA	NA	0.6	disease	0.44	neutral	0.5	disease	0	1	deleterious	0.03	neutral	5	deleterious	0.74	deleterious	-1.92	low_impact	-0.92	medium_impact	1.77	medium_impact	0.24	0.8	21.57	25.24	0.4	N	0.94	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10927	10927	T	G	MI.16682	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	168	56	F	L	ttT/ttG	-0.17	0	0.01	benign	0.01	neutral	0.64	neutral	1.72	neutral	-0.79	neutral	-2.48	neutral_impact	0.64	0.75	neutral	0.82	neutral	2.27	17.94	deleterious	0.17	0.45	NA	NA	0.14	neutral	0.31	neutral	0.23	neutral	5	0.33	neutral	0.82	deleterious	-6	neutral	0.68	deleterious	1.16	medium_impact	0.34	medium_impact	-0.49	medium_impact	0.71	0.85	21.57	25.24	0.34	N	0.43	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10927	10927	T	A	MI.16683	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	168	56	F	L	ttT/ttA	-0.17	0	0.01	benign	0.01	neutral	0.64	neutral	1.72	neutral	-0.79	neutral	-2.48	neutral_impact	0.64	0.75	neutral	0.82	neutral	2.42	18.92	deleterious	0.17	0.45	NA	NA	0.14	neutral	0.31	neutral	0.23	neutral	5	0.33	neutral	0.82	deleterious	-6	neutral	0.68	deleterious	1.16	medium_impact	0.34	medium_impact	-0.49	medium_impact	0.71	0.85	21.57	25.24	0.34	N	0.43	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10928	10928	T	G	MI.16684	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	169	57	S	A	Tcc/Gcc	-2.48	0	0	possibly_damaging	0.84	neutral	0.81	neutral	1.56	neutral	-0.2	neutral	-0.16	neutral_impact	0.44	0.73	neutral	0.61	neutral	1.00	10.67	neutral	0.21	0.45	NA	NA	0.03	neutral	0.51	disease	0.16	neutral	7	0.81	neutral	0.49	deleterious	-3	neutral	0.67	deleterious	-1.39	low_impact	0.56	medium_impact	-0.69	medium_impact	0.34	0.8	25.49	24.04	0.35	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10928	10928	T	C	MI.16685	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	169	57	S	P	Tcc/Ccc	-2.48	0	0	probably_damaging	0.98	neutral	0.06	neutral	1.44	neutral	-2.97	neutral	-2.1	medium_impact	2.35	0.59	damaging	0.16	damaging	2.48	19.31	deleterious	0.06	0.35	NA	NA	0.56	disease	0.5	neutral	0.52	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-2.31	low_impact	-0.47	medium_impact	1.2	medium_impact	0.23	0.8	25.49	24.04	0.34	N	0.94	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10928	10928	T	A	MI.16686	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	169	57	S	T	Tcc/Acc	-2.48	0	0	probably_damaging	0.92	neutral	0.22	neutral	1.52	neutral	-0.76	neutral	-0.76	low_impact	1.65	0.75	neutral	0.49	neutral	1.91	15.66	deleterious	0.22	0.45	NA	NA	0.1	neutral	0.2	neutral	0.26	neutral	5	0.95	neutral	0.15	neutral	-2	neutral	0.67	deleterious	-1.71	low_impact	-0.11	medium_impact	0.51	medium_impact	0.41	0.8	25.49	24.04	0.48	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10929	10929	C	A	MI.16687	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	170	57	S	Y	tCc/tAc	2.6	0.44	0	probably_damaging	0.94	neutral	0.41	neutral	1.45	neutral	-2.63	neutral	0.1	medium_impact	2.35	0.8	neutral	0.51	neutral	1.35	12.51	neutral	0.09	0.35	NA	NA	0.29	neutral	0.33	neutral	0.16	neutral	7	0.94	neutral	0.24	neutral	1	deleterious	0.72	deleterious	-1.84	low_impact	0.11	medium_impact	1.2	medium_impact	0.20	0.8	25.49	24.04	0.4	N	0.77	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10929	10929	C	G	MI.16688	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	170	57	S	C	tCc/tGc	2.6	0.44	0	probably_damaging	0.99	neutral	0.06	neutral	1.43	deleterious	-3.78	neutral	-1.27	medium_impact	2.35	0.77	neutral	0.19	damaging	2.17	17.31	deleterious	0.12	0.4	NA	NA	0.39	neutral	0.53	disease	0.33	neutral	3	1	deleterious	0.04	neutral	1	deleterious	0.71	deleterious	-2.59	low_impact	-0.47	medium_impact	1.2	medium_impact	0.21	0.8	25.49	24.04	0.38	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10929	10929	C	T	MI.16689	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	170	57	S	F	tCc/tTc	2.6	0.44	0	benign	0.23	neutral	0.52	neutral	1.48	neutral	-1.58	neutral	1.16	neutral_impact	-0.24	0.77	neutral	0.95	neutral	1.39	12.72	neutral	0.1	0.4	NA	NA	0.22	neutral	0.23	neutral	0.16	neutral	7	0.37	neutral	0.65	deleterious	-6	neutral	0.70	deleterious	-0.23	medium_impact	0.22	medium_impact	-1.36	low_impact	0.13	0.8	25.49	24.04	0.32	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8471	8471	C	A	MI.1669	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	106	36	P	T	Cct/Act	-2.42	0	0	benign	0.04	neutral	0.55	neutral	2.01	neutral	0.08	neutral	-0.65	neutral_impact	0.28	0.97	neutral	0.95	neutral	0.05	3.11	deleterious	0.40256048	0.85	0.25	neutral	0.14	neutral	0.32	neutral	0.11	neutral	8	0.4	neutral	0.76	deleterious	-6	neutral	0.15	neutral	0.55	medium_impact	0.34	medium_impact	-0.86	medium_impact	0.48	0.85	19.12	8.87	0.34	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10931	10931	T	G	MI.16690	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	172	58	S	A	Tcc/Gcc	-5.93	0	0	possibly_damaging	0.53	neutral	0.43	neutral	1.57	neutral	1.31	neutral	-1.16	low_impact	1.48	0.76	neutral	0.96	neutral	2.34	18.43	deleterious	0.24	0.45	NA	NA	0.08	neutral	0.19	neutral	0.22	neutral	6	0.57	neutral	0.45	neutral	-3	neutral	0.66	deleterious	-0.77	medium_impact	0.13	medium_impact	0.34	medium_impact	0.38	0.8	21.13	19.5	0.5	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10931	10931	T	C	MI.16691	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	172	58	S	P	Tcc/Ccc	-5.93	0	0	benign	0.08	neutral	0.15	neutral	1.48	neutral	-2.04	deleterious	-2.6	medium_impact	2.63	0.64	neutral	0.39	neutral	3.83	23.40	deleterious	0.07	0.35	NA	NA	0.49	neutral	0.55	disease	0.65	disease	3	0.83	neutral	0.54	deleterious	-3	neutral	0.75	deleterious	0.28	medium_impact	-0.22	medium_impact	1.48	medium_impact	0.28	0.8	21.13	19.5	0.43	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10931	10931	T	A	MI.16692	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	172	58	S	T	Tcc/Acc	-5.93	0	0	possibly_damaging	0.78	neutral	0.8	neutral	1.6	neutral	-0.15	neutral	-0.04	neutral_impact	0.06	0.72	neutral	1	neutral	0.95	10.37	neutral	0.24	0.45	NA	NA	0.03	neutral	0.24	neutral	0.19	neutral	6	0.74	neutral	0.51	deleterious	-3	neutral	0.66	deleterious	-1.23	low_impact	0.54	medium_impact	-1.07	low_impact	0.43	0.8	21.13	19.5	0.43	N	0.61	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10932	10932	C	A	MI.16693	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	173	58	S	Y	tCc/tAc	-0.17	0	0	possibly_damaging	0.87	neutral	0.84	neutral	1.53	neutral	-0.85	deleterious	-3.11	medium_impact	2.63	0.79	neutral	0.56	neutral	3.86	23.50	deleterious	0.08	0.35	NA	NA	0.25	neutral	0.51	disease	0.25	neutral	5	0.85	neutral	0.49	deleterious	0	NA	0.70	deleterious	-1.49	low_impact	0.61	medium_impact	1.48	medium_impact	0.22	0.8	21.13	19.5	0.26	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10932	10932	C	T	MI.16694	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	173	58	S	F	tCc/tTc	-0.17	0	0	benign	0.11	neutral	0.73	neutral	1.52	neutral	0	deleterious	-3.03	low_impact	1.94	0.77	neutral	0.51	neutral	4.04	23.70	deleterious	0.09	0.35	NA	NA	0.28	neutral	0.37	neutral	0.16	neutral	7	0.16	neutral	0.81	deleterious	-6	neutral	0.70	deleterious	0.14	medium_impact	0.44	medium_impact	0.79	medium_impact	0.14	0.8	21.13	19.5	0.24	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10932	10932	C	G	MI.16695	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	173	58	S	C	tCc/tGc	-0.17	0	0	probably_damaging	0.98	neutral	0.3	neutral	1.52	neutral	-1.9	neutral	-2.4	medium_impact	2.28	0.78	neutral	0.41	neutral	3.43	23.00	deleterious	0.08	0.35	NA	NA	0.28	neutral	0.56	disease	0.34	neutral	3	0.98	neutral	0.16	neutral	1	deleterious	0.69	deleterious	-2.31	low_impact	0	medium_impact	1.13	medium_impact	0.23	0.8	21.13	19.5	0.35	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10934	10934	G	T	MI.16696	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	175	59	D	Y	Gac/Tac	-15.85	0	0	probably_damaging	1	deleterious	0	neutral	-0.16	deleterious	-9.14	deleterious	-6.83	high_impact	3.57	0.58	damaging	0.14	damaging	3.75	23.30	deleterious	0.02	0.35	NA	NA	0.73	disease	0.86	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.41	high_impact	0.10	0.8	47.28	9.34	0.34	N	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10934	10934	G	C	MI.16697	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	175	59	D	H	Gac/Cac	-15.85	0	0	probably_damaging	0.99	deleterious	0	neutral	-0.16	deleterious	-7.93	deleterious	-5.35	high_impact	3.57	0.59	damaging	0.14	damaging	3.51	23.10	deleterious	0.03	0.35	NA	NA	0.66	disease	0.89	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.59	low_impact	-1.48	low_impact	2.41	high_impact	0.31	0.8	47.28	9.34	0.35	N	0.99	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10934	10934	G	A	MI.16698	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	175	59	D	N	Gac/Aac	-15.85	0	0	probably_damaging	0.97	neutral	0.07	neutral	-0.11	deleterious	-5.72	deleterious	-3.83	high_impact	3.57	0.54	damaging	0.17	damaging	4.05	23.70	deleterious	0.16	0.45	NA	NA	0.52	disease	0.8	disease	0.72	disease	4	0.99	deleterious	0.05	neutral	2	deleterious	0.79	deleterious	-2.14	low_impact	-0.43	medium_impact	2.41	high_impact	0.55	0.8	47.28	9.34	0.41	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10935	10935	A	T	MI.16699	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	176	59	D	V	gAc/gTc	5.13	1	0	probably_damaging	0.98	deleterious	0	neutral	-0.16	deleterious	-8.48	deleterious	-6.75	high_impact	3.57	0.57	damaging	0.15	damaging	4.24	23.90	deleterious	0.02	0.35	NA	NA	0.7	disease	0.84	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.31	low_impact	-1.48	low_impact	2.41	high_impact	0.11	0.8	47.28	9.34	0.56	P	0.99	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8604	8604	T	A	MI.167	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	78	26	F	L	ttT/ttA	3.83	0.39	0	benign	0	neutral	1	neutral	4.49	neutral	0.67	neutral	-1.96	neutral_impact	-0.38	0.96	neutral	0.92	neutral	-0.30	0.66	neutral	0.42	0.65	0.29	neutral	0.15	neutral	0.27	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.98	high_impact	-1.42	low_impact	0.39	0.9	15.49	8.03	0.36	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8471	8471	C	G	MI.1670	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	106	36	P	A	Cct/Gct	-2.42	0	0	benign	0.02	neutral	0.62	neutral	1.98	neutral	-0.31	neutral	-1.55	low_impact	1.77	0.99	neutral	0.88	neutral	-0.82	0.04	neutral	0.38800886	0.85	0.18	neutral	0.06	neutral	0.41	neutral	0.04	neutral	9	0.35	neutral	0.8	deleterious	-6	neutral	0.14	neutral	0.85	medium_impact	0.41	medium_impact	0.42	medium_impact	0.40	0.85	19.12	8.87	0.43	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10935	10935	A	G	MI.16700	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	176	59	D	G	gAc/gGc	5.13	1	0	probably_damaging	0.97	deleterious	0	neutral	-0.13	deleterious	-6.31	deleterious	-5.36	medium_impact	3.22	0.58	damaging	0.17	damaging	4.44	24.20	deleterious	0.04	0.35	NA	NA	0.63	disease	0.84	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-2.14	low_impact	-1.48	low_impact	2.06	high_impact	0.28	0.8	47.28	9.34	0.57	P	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10935	10935	A	C	MI.16701	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	176	59	D	A	gAc/gCc	5.13	1	0	probably_damaging	0.94	deleterious	0	neutral	-0.14	deleterious	-6.73	deleterious	-6.09	high_impact	3.57	0.66	neutral	0.17	damaging	4.06	23.70	deleterious	0.03	0.35	NA	NA	0.52	disease	0.84	disease	0.77	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.79	deleterious	-1.84	low_impact	-1.48	low_impact	2.41	high_impact	0.28	0.8	47.28	9.34	0.59	P	0.93	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10936	10936	C	G	MI.16702	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	177	59	D	E	gaC/gaG	6.75	1	0	benign	0.3	deleterious	0	neutral	-0.08	deleterious	-5.17	deleterious	-3.06	high_impact	3.57	0.61	neutral	0.17	damaging	3.74	23.30	deleterious	0.06	0.35	NA	NA	0.48	neutral	0.85	disease	0.71	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.78	deleterious	-0.37	medium_impact	-1.48	low_impact	2.41	high_impact	0.31	0.8	47.28	9.34	0.64	P	0.95	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10936	10936	C	A	MI.16703	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	177	59	D	E	gaC/gaA	6.75	1	0	benign	0.3	deleterious	0	neutral	-0.08	deleterious	-5.17	deleterious	-3.06	high_impact	3.57	0.61	neutral	0.17	damaging	4.06	23.70	deleterious	0.06	0.35	NA	NA	0.48	neutral	0.85	disease	0.71	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.78	deleterious	-0.37	medium_impact	-1.48	low_impact	2.41	high_impact	0.31	0.8	47.28	9.34	0.64	P	0.95	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10937	10937	C	A	MI.16704	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	178	60	P	T	Ccc/Acc	-0.17	0	0	possibly_damaging	0.52	neutral	0.61	neutral	1.61	neutral	-0.56	deleterious	-2.69	medium_impact	2.15	0.8	neutral	0.4	neutral	3.64	23.20	deleterious	0.18	0.45	NA	NA	0.12	neutral	0.35	neutral	0.25	neutral	5	0.45	neutral	0.55	deleterious	0	NA	0.68	deleterious	-0.75	medium_impact	0.31	medium_impact	1	medium_impact	0.52	0.8	18.52	15.16	0.26	N	0.35	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10937	10937	C	T	MI.16705	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	178	60	P	S	Ccc/Tcc	-0.17	0	0	probably_damaging	0.94	neutral	0.78	neutral	1.68	neutral	-0.31	neutral	-1.96	low_impact	0.82	0.76	neutral	0.97	neutral	2.08	16.70	deleterious	0.19	0.45	NA	NA	0.1	neutral	0.29	neutral	0.22	neutral	6	0.93	neutral	0.42	neutral	-2	neutral	0.68	deleterious	-1.84	low_impact	0.51	medium_impact	-0.32	medium_impact	0.18	0.8	18.52	15.16	0.34	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10937	10937	C	G	MI.16706	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	178	60	P	A	Ccc/Gcc	-0.17	0	0	possibly_damaging	0.9	neutral	0.8	neutral	1.6	neutral	-0.47	deleterious	-2.5	medium_impact	3.04	0.78	neutral	0.88	neutral	2.84	21.60	deleterious	0.17	0.45	NA	NA	0.08	neutral	0.47	neutral	0.21	neutral	6	0.88	neutral	0.45	neutral	0	NA	0.68	deleterious	-1.61	low_impact	0.54	medium_impact	1.88	medium_impact	0.64	0.8	18.52	15.16	0.35	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10938	10938	C	T	MI.16707	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	179	60	P	L	cCc/cTc	-0.86	0	0	probably_damaging	0.96	neutral	0.79	neutral	1.62	neutral	-1.58	deleterious	-4.26	medium_impact	2.49	0.76	neutral	0.32	neutral	4.21	23.90	deleterious	0.15	0.4	NA	NA	0.22	neutral	0.47	neutral	0.19	neutral	6	0.95	neutral	0.42	neutral	1	deleterious	0.70	deleterious	-2.01	low_impact	0.52	medium_impact	1.34	medium_impact	0.64	0.8	18.52	15.16	0.24	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10938	10938	C	G	MI.16708	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	179	60	P	R	cCc/cGc	-0.86	0	0	probably_damaging	0.98	neutral	0.54	neutral	1.58	neutral	-0.94	deleterious	-3.37	medium_impact	3.04	0.7	neutral	0.2	damaging	3.49	23.10	deleterious	0.09	0.35	NA	NA	0.33	neutral	0.64	disease	0.39	neutral	2	0.98	deleterious	0.28	neutral	1	deleterious	0.72	deleterious	-2.31	low_impact	0.24	medium_impact	1.88	medium_impact	0.40	0.8	18.52	15.16	0.26	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10938	10938	C	A	MI.16709	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	179	60	P	H	cCc/cAc	-0.86	0	0	probably_damaging	1	neutral	0.57	neutral	1.56	neutral	-1.92	deleterious	-3.03	medium_impact	2.23	0.81	neutral	0.47	neutral	3.85	23.40	deleterious	0.1	0.4	NA	NA	0.25	neutral	0.5	neutral	0.19	neutral	6	0.99	deleterious	0.29	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	0.27	medium_impact	1.08	medium_impact	0.29	0.8	18.52	15.16	0.26	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8472	8472	C	T	MI.1671	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	107	36	P	L	cCt/cTt	-4.27	0	0.01	benign	0.02	neutral	0.33	neutral	1.92	neutral	-2.03	deleterious	-2.98	medium_impact	2.12	0.99	neutral	0.53	neutral	0.16	4.20	deleterious	0.52090386	0.85	0.29	neutral	0.14	neutral	0.41	neutral	0.1	neutral	8	0.66	neutral	0.66	deleterious	-3	neutral	0.16	neutral	0.85	medium_impact	0.12	medium_impact	0.72	medium_impact	0.73	0.85	19.12	8.87	0.55	N	0.75	polymorphism	1	0.06	rs879209186	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	10940	10940	C	G	MI.16710	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	181	61	L	V	Cta/Gta	-6.16	0	0	probably_damaging	1	neutral	0.28	neutral	1.28	neutral	-2.99	neutral	-2.18	medium_impact	2.56	0.7	neutral	0.2	damaging	3.26	22.80	deleterious	0.25	0.45	NA	NA	0.15	neutral	0.45	neutral	0.21	neutral	6	1	deleterious	0.14	neutral	1	deleterious	0.69	deleterious	-3.54	low_impact	-0.03	medium_impact	1.41	medium_impact	0.50	0.8	45.53	8.4	0.36	N	0.89	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10940	10940	C	A	MI.16711	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	181	61	L	M	Cta/Ata	-6.16	0	0	probably_damaging	1	neutral	0.25	neutral	1.23	deleterious	-3.88	neutral	-1.5	medium_impact	3.02	0.69	neutral	0.16	damaging	3.60	23.20	deleterious	0.25	0.45	NA	NA	0.13	neutral	0.46	neutral	0.21	neutral	6	1	deleterious	0.13	neutral	1	deleterious	0.69	deleterious	-3.54	low_impact	-0.07	medium_impact	1.86	medium_impact	0.70	0.85	45.53	8.4	0.4	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10941	10941	T	C	MI.16712	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	182	61	L	P	cTa/cCa	-2.24	0	0	probably_damaging	1	deleterious	0	neutral	1.14	deleterious	-6.55	deleterious	-5.3	medium_impact	3.37	0.61	neutral	0.11	damaging	3.76	23.30	deleterious	0.02	0.35	NA	NA	0.55	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	2.21	high_impact	0.30	0.8	45.53	8.4	0.34	N	0.98	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10941	10941	T	A	MI.16713	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	182	61	L	Q	cTa/cAa	-2.24	0	0	probably_damaging	1	deleterious	0.01	neutral	1.14	deleterious	-6.15	deleterious	-4.56	medium_impact	3.37	0.69	neutral	0.12	damaging	3.93	23.50	deleterious	0.02	0.35	NA	NA	0.48	neutral	0.66	disease	0.53	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.74	deleterious	-3.54	low_impact	-0.92	medium_impact	2.21	high_impact	0.32	0.8	45.53	8.4	0.34	N	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10941	10941	T	G	MI.16714	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	182	61	L	R	cTa/cGa	-2.24	0	0	probably_damaging	1	deleterious	0.01	neutral	1.14	deleterious	-6	deleterious	-4.57	medium_impact	3.37	0.63	neutral	0.11	damaging	4.01	23.60	deleterious	0.02	0.35	NA	NA	0.58	disease	0.77	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	2.21	high_impact	0.14	0.8	45.53	8.4	0.36	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10943	10943	A	T	MI.16715	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	184	62	T	S	Aca/Tca	-0.86	0.05	0	benign	0.02	neutral	1	neutral	2.94	neutral	5.4	neutral	1.88	neutral_impact	-1.59	0.76	neutral	0.89	neutral	-1.54	0.00	neutral	0.32	0.5	NA	NA	0.03	neutral	0.28	neutral	0.14	neutral	7	0.02	neutral	0.99	deleterious	-6	neutral	0.09	neutral	0.87	medium_impact	1.88	high_impact	-2.7	low_impact	0.42	0.8	24.18	26.75	0.32	N	0.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10943	10943	A	G	MI.16716	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	184	62	T	A	Aca/Gca	-0.86	0.05	0	benign	0.02	deleterious	0.03	neutral	1.63	neutral	0.91	neutral	-0.24	low_impact	1.15	0.75	neutral	0.8	neutral	1.43	12.96	neutral	0.24	0.45	NA	NA	0.16	neutral	0.47	neutral	0.21	neutral	6	0.97	neutral	0.51	deleterious	-2	neutral	0.23	neutral	0.87	medium_impact	-0.64	medium_impact	0.01	medium_impact	0.24	0.8	24.18	26.75	0.47	N	0.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10943	10943	A	C	MI.16717	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	184	62	T	P	Aca/Cca	-0.86	0.05	0	possibly_damaging	0.72	deleterious	0	neutral	1.55	neutral	-1.61	neutral	-1.75	low_impact	1.7	0.62	neutral	0.47	neutral	3.04	22.40	deleterious	0.06	0.35	NA	NA	0.59	disease	0.7	disease	0.69	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.68	deleterious	-1.1	low_impact	-1.48	low_impact	0.56	medium_impact	0.32	0.8	24.18	26.75	0.37	N	0.39	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10944	10944	C	T	MI.16718	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	185	62	T	M	aCa/aTa	3.06	0.99	0	probably_damaging	0.94	deleterious	0	neutral	1.54	neutral	-2.75	neutral	-1.75	low_impact	1.7	0.73	neutral	0.55	neutral	3.76	23.30	deleterious	0.06	0.35	NA	NA	0.33	neutral	0.58	disease	0.35	neutral	3	1	deleterious	0.03	neutral	2	deleterious	0.70	deleterious	-1.84	low_impact	-1.48	low_impact	0.56	medium_impact	0.56	0.8	24.18	26.75	0.58	P	0.48	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10944	10944	C	A	MI.16719	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	185	62	T	K	aCa/aAa	3.06	0.99	0	possibly_damaging	0.44	deleterious	0	neutral	1.56	neutral	-0.97	neutral	-1.05	low_impact	1.7	0.68	neutral	0.56	neutral	2.63	20.40	deleterious	0.07	0.35	NA	NA	0.39	neutral	0.67	disease	0.35	neutral	3	1	deleterious	0.28	neutral	1	deleterious	0.39	neutral	-0.62	medium_impact	-1.48	low_impact	0.56	medium_impact	0.37	0.8	24.18	26.75	0.58	P	0.44	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8472	8472	C	A	MI.1672	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	107	36	P	H	cCt/cAt	-4.27	0	0.01	benign	0	neutral	0.16	neutral	1.92	neutral	-1.89	neutral	-0.41	low_impact	1.77	1	neutral	0.9	neutral	0.09	3.52	deleterious	0.40896277	0.85	0.31	neutral	0.16	neutral	0.44	neutral	0.13	neutral	7	0.84	neutral	0.58	deleterious	-6	neutral	0.16	neutral	2.09	high_impact	-0.12	medium_impact	0.42	medium_impact	0.40	0.85	19.12	8.87	0.5	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10946	10946	A	T	MI.16720	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	187	63	T	S	Acc/Tcc	-9.39	0	0	benign	0.18	neutral	0.44	neutral	1.6	neutral	0.15	neutral	-0.97	low_impact	0.84	0.7	neutral	0.92	neutral	1.73	14.57	neutral	0.35	0.5	NA	NA	0.07	neutral	0.34	neutral	0.17	neutral	7	0.47	neutral	0.63	deleterious	-6	neutral	0.67	deleterious	-0.1	medium_impact	0.14	medium_impact	-0.3	medium_impact	0.69	0.85	20.7	16.72	0.44	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10946	10946	A	C	MI.16721	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	187	63	T	P	Acc/Ccc	-9.39	0	0	probably_damaging	0.97	neutral	0.19	neutral	1.46	deleterious	-3.02	deleterious	-3.22	medium_impact	2.92	0.67	neutral	0.36	neutral	3.81	23.40	deleterious	0.07	0.35	NA	NA	0.63	disease	0.73	disease	0.75	disease	5	0.98	deleterious	0.11	neutral	1	deleterious	0.76	deleterious	-2.14	low_impact	-0.15	medium_impact	1.76	medium_impact	0.45	0.8	20.7	16.72	0.33	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10946	10946	A	G	MI.16722	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	187	63	T	A	Acc/Gcc	-9.39	0	0	benign	0.12	neutral	0.51	neutral	1.63	neutral	0.42	neutral	-1.95	neutral_impact	0.64	0.76	neutral	0.99	neutral	2.46	19.20	deleterious	0.38	0.5	NA	NA	0.08	neutral	0.37	neutral	0.2	neutral	6	0.41	neutral	0.7	deleterious	-6	neutral	0.67	deleterious	0.1	medium_impact	0.21	medium_impact	-0.49	medium_impact	0.36	0.8	20.7	16.72	0.39	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10947	10947	C	T	MI.16723	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	188	63	T	I	aCc/aTc	-0.86	0	0	probably_damaging	0.94	neutral	0.4	neutral	1.55	neutral	-0.43	deleterious	-3.46	medium_impact	2.03	0.72	neutral	0.6	neutral	3.77	23.40	deleterious	0.18	0.45	NA	NA	0.38	neutral	0.47	neutral	0.19	neutral	6	0.94	neutral	0.23	neutral	1	deleterious	0.71	deleterious	-1.84	low_impact	0.1	medium_impact	0.88	medium_impact	0.60	0.8	20.7	16.72	0.34	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10947	10947	C	G	MI.16724	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	188	63	T	S	aCc/aGc	-0.86	0	0	benign	0.18	neutral	0.44	neutral	1.6	neutral	0.15	neutral	-0.97	low_impact	0.84	0.7	neutral	0.92	neutral	1.42	12.87	neutral	0.35	0.5	NA	NA	0.07	neutral	0.34	neutral	0.17	neutral	7	0.47	neutral	0.63	deleterious	-6	neutral	0.67	deleterious	-0.1	medium_impact	0.14	medium_impact	-0.3	medium_impact	0.69	0.85	20.7	16.72	0.47	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10947	10947	C	A	MI.16725	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	188	63	T	N	aCc/aAc	-0.86	0	0	possibly_damaging	0.88	neutral	0.3	neutral	1.48	neutral	-2.27	neutral	-2.34	medium_impact	2.58	0.71	neutral	0.51	neutral	3.64	23.20	deleterious	0.3	0.45	NA	NA	0.44	neutral	0.63	disease	0.43	neutral	1	0.9	neutral	0.21	neutral	0	NA	0.71	deleterious	-1.53	low_impact	0	medium_impact	1.43	medium_impact	0.52	0.8	20.7	16.72	0.39	N	0.39	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10949	10949	C	A	MI.16726	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	190	64	P	T	Ccc/Acc	-5.01	0	0	possibly_damaging	0.76	neutral	0.38	neutral	1.34	neutral	-0.48	deleterious	-6.12	high_impact	3.55	0.66	neutral	0.43	neutral	3.57	23.20	deleterious	0.18	0.45	NA	NA	0.42	neutral	0.65	disease	0.4	neutral	2	0.77	neutral	0.31	neutral	1	deleterious	0.72	deleterious	-1.19	low_impact	0.08	medium_impact	2.39	high_impact	0.60	0.8	46.41	8.92	0.4	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10949	10949	C	T	MI.16727	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	190	64	P	S	Ccc/Tcc	-5.01	0	0	possibly_damaging	0.76	neutral	0.41	neutral	1.36	neutral	-1.05	deleterious	-6.12	high_impact	3.55	0.73	neutral	0.52	neutral	3.76	23.30	deleterious	0.21	0.45	NA	NA	0.47	neutral	0.64	disease	0.41	neutral	2	0.76	neutral	0.33	neutral	1	deleterious	0.74	deleterious	-1.19	low_impact	0.11	medium_impact	2.39	high_impact	0.25	0.8	46.41	8.92	0.39	N	0.71	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10949	10949	C	G	MI.16728	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	190	64	P	A	Ccc/Gcc	-5.01	0	0	benign	0.08	neutral	0.5	neutral	1.36	neutral	-0.21	deleterious	-6.12	high_impact	3.55	0.69	neutral	0.5	neutral	2.97	22.10	deleterious	0.19	0.45	NA	NA	0.32	neutral	0.61	disease	0.37	neutral	3	0.43	neutral	0.71	deleterious	-2	neutral	0.72	deleterious	0.28	medium_impact	0.2	medium_impact	2.39	high_impact	0.62	0.8	46.41	8.92	0.42	N	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10950	10950	C	G	MI.16729	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	191	64	P	R	cCc/cGc	5.6	1	0	probably_damaging	0.93	neutral	0.34	neutral	1.3	neutral	-2.67	deleterious	-6.89	high_impact	3.55	0.73	neutral	0.44	neutral	3.51	23.10	deleterious	0.06	0.35	NA	NA	0.71	disease	0.78	disease	0.74	disease	5	0.94	neutral	0.21	neutral	2	deleterious	0.78	deleterious	-1.77	low_impact	0.04	medium_impact	2.39	high_impact	0.54	0.8	46.41	8.92	0.66	P	0.58	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8472	8472	C	G	MI.1673	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	107	36	P	R	cCt/cGt	-4.27	0	0.01	benign	0	neutral	0.44	neutral	2.11	neutral	1.08	neutral	-1.51	medium_impact	2.81	0.99	neutral	0.43	neutral	-0.05	2.14	deleterious	0.42878708	0.85	0.26	neutral	0.19	neutral	0.51	disease	0.12	neutral	8	0.56	neutral	0.72	deleterious	-3	neutral	0.16	neutral	2.09	high_impact	0.23	medium_impact	1.31	medium_impact	0.39	0.85	19.12	8.87	0.41	N	0.52	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10950	10950	C	A	MI.16730	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	191	64	P	H	cCc/cAc	5.6	1	0	probably_damaging	0.98	neutral	0.53	neutral	1.28	deleterious	-3.22	deleterious	-6.89	high_impact	3.55	0.68	neutral	0.36	neutral	3.88	23.50	deleterious	0.09	0.35	NA	NA	0.66	disease	0.72	disease	0.71	disease	4	0.97	neutral	0.28	neutral	2	deleterious	0.77	deleterious	-2.31	low_impact	0.23	medium_impact	2.39	high_impact	0.41	0.8	46.41	8.92	0.56	P	0.70	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10950	10950	C	T	MI.16731	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	191	64	P	L	cCc/cTc	5.6	1	0	benign	0.08	neutral	0.69	neutral	1.36	neutral	0.82	deleterious	-7.65	medium_impact	3.2	0.62	neutral	0.44	neutral	4.28	24.00	deleterious	0.14	0.4	NA	NA	0.64	disease	0.64	disease	0.59	disease	2	0.21	neutral	0.81	deleterious	-3	neutral	0.75	deleterious	0.28	medium_impact	0.4	medium_impact	2.04	high_impact	0.57	0.8	46.41	8.92	0.59	P	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10952	10952	C	G	MI.16732	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	193	65	L	V	Ctc/Gtc	-11.24	0	0	possibly_damaging	0.86	deleterious	0	neutral	0.03	deleterious	-5.5	neutral	-2.29	high_impact	3.57	0.56	damaging	0.51	neutral	3.30	22.90	deleterious	0.26	0.45	NA	NA	0.24	neutral	0.66	disease	0.39	neutral	2	1	deleterious	0.07	neutral	5	deleterious	0.73	deleterious	-1.46	low_impact	-1.48	low_impact	2.41	high_impact	0.44	0.8	46.41	9.4	0.48	P	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10952	10952	C	A	MI.16733	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	193	65	L	I	Ctc/Atc	-11.24	0	0	possibly_damaging	0.86	deleterious	0.04	neutral	0.06	deleterious	-5.03	neutral	-1.52	high_impact	3.57	0.58	damaging	0.55	neutral	3.94	23.50	deleterious	0.21	0.45	NA	NA	0.28	neutral	0.65	disease	0.39	neutral	2	0.98	neutral	0.09	neutral	5	deleterious	0.73	deleterious	-1.46	low_impact	-0.57	medium_impact	2.41	high_impact	0.55	0.8	46.41	9.4	0.51	P	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10952	10952	C	T	MI.16734	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	193	65	L	F	Ctc/Ttc	-11.24	0	0	benign	0.29	neutral	0.1	neutral	0.04	deleterious	-5.38	deleterious	-3	high_impact	3.57	0.61	neutral	0.59	neutral	3.79	23.40	deleterious	0.22	0.45	NA	NA	0.3	neutral	0.58	disease	0.37	neutral	3	0.88	neutral	0.41	neutral	-2	neutral	0.74	deleterious	-0.35	medium_impact	-0.33	medium_impact	2.41	high_impact	0.33	0.8	46.41	9.4	0.49	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10953	10953	T	G	MI.16735	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	194	65	L	R	cTc/cGc	-0.17	0	0	probably_damaging	0.98	deleterious	0	neutral	-0.02	deleterious	-8.58	deleterious	-4.57	high_impact	3.57	0.58	damaging	0.37	neutral	4.06	23.70	deleterious	0.02	0.35	NA	NA	0.64	disease	0.76	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.31	low_impact	-1.48	low_impact	2.41	high_impact	0.12	0.8	46.41	9.4	0.45	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10953	10953	T	C	MI.16736	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	194	65	L	P	cTc/cCc	-0.17	0	0	probably_damaging	0.99	deleterious	0	neutral	-0.02	deleterious	-7.93	deleterious	-5.34	high_impact	3.57	0.55	damaging	0.44	neutral	3.77	23.40	deleterious	0.02	0.35	NA	NA	0.5	neutral	0.74	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.59	low_impact	-1.48	low_impact	2.41	high_impact	0.27	0.8	46.41	9.4	0.39	N	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10953	10953	T	A	MI.16737	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	194	65	L	H	cTc/cAc	-0.17	0	0	probably_damaging	0.99	deleterious	0	neutral	-0.03	deleterious	-9.3	deleterious	-5.32	high_impact	3.57	0.56	damaging	0.39	neutral	3.99	23.60	deleterious	0.04	0.35	NA	NA	0.56	disease	0.74	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.59	low_impact	-1.48	low_impact	2.41	high_impact	0.23	0.8	46.41	9.4	0.4	N	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10955	10955	C	A	MI.16738	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	196	66	L	M	Cta/Ata	-11.01	0	0	probably_damaging	0.97	neutral	0.12	neutral	1.39	neutral	-1.83	neutral	-1.25	medium_impact	2.61	0.79	neutral	0.35	neutral	3.52	23.10	deleterious	0.27	0.45	NA	NA	0.15	neutral	0.34	neutral	0.22	neutral	6	0.99	deleterious	0.08	neutral	1	deleterious	0.70	deleterious	-2.14	low_impact	-0.28	medium_impact	1.46	medium_impact	0.46	0.8	20.7	19.59	0.42	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10955	10955	C	G	MI.16739	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	196	66	L	V	Cta/Gta	-11.01	0	0	benign	0.17	neutral	0.22	neutral	1.55	neutral	-0.2	neutral	-1.84	medium_impact	3.07	0.83	neutral	0.61	neutral	3.22	22.70	deleterious	0.25	0.45	NA	NA	0.12	neutral	0.35	neutral	0.24	neutral	5	0.74	neutral	0.53	deleterious	-3	neutral	0.69	deleterious	-0.07	medium_impact	-0.11	medium_impact	1.91	medium_impact	0.35	0.8	20.7	19.59	0.49	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8474	8474	C	G	MI.1674	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	109	37	P	A	Ccc/Gcc	-0.1	0	0	probably_damaging	0.99	neutral	0.25	neutral	1.83	deleterious	-3.26	deleterious	-5.57	medium_impact	2.88	1	neutral	0.73	neutral	1.88	15.48	deleterious	0.60038707	0.85	0.76	disease	0.05	neutral	0.58	disease	0.08	neutral	8	0.99	deleterious	0.13	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	0.02	medium_impact	1.37	medium_impact	0.64	0.85	NA	NA	0.55	P	0.64	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10956	10956	T	C	MI.16740	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	197	66	L	P	cTa/cCa	-1.55	0	0	probably_damaging	0.99	deleterious	0	neutral	1.32	deleterious	-4.4	deleterious	-5.04	medium_impact	3.42	0.65	neutral	0.13	damaging	3.78	23.40	deleterious	0.05	0.35	NA	NA	0.53	disease	0.71	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-2.59	low_impact	-1.48	low_impact	2.26	high_impact	0.26	0.8	20.7	19.59	0.31	N	0.86	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10956	10956	T	A	MI.16741	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	197	66	L	Q	cTa/cAa	-1.55	0	0	probably_damaging	0.99	deleterious	0	neutral	1.32	deleterious	-4	deleterious	-4.32	medium_impact	3.42	0.73	neutral	0.14	damaging	3.95	23.60	deleterious	0.06	0.35	NA	NA	0.44	neutral	0.58	disease	0.42	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-2.59	low_impact	-1.48	low_impact	2.26	high_impact	0.20	0.8	20.7	19.59	0.36	N	0.91	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10956	10956	T	G	MI.16742	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	197	66	L	R	cTa/cGa	-1.55	0	0	probably_damaging	0.98	deleterious	0	neutral	1.32	deleterious	-3.84	deleterious	-4.38	medium_impact	3.42	0.65	neutral	0.12	damaging	4.02	23.60	deleterious	0.04	0.35	NA	NA	0.58	disease	0.7	disease	0.69	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-2.31	low_impact	-1.48	low_impact	2.26	high_impact	0.16	0.8	20.7	19.59	0.33	N	0.98	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10958	10958	A	T	MI.16743	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	199	67	M	L	Ata/Tta	-3.63	0	0	benign	0.08	neutral	0.93	neutral	1.77	neutral	2.55	neutral	0.15	neutral_impact	0.41	0.79	neutral	0.8	neutral	3.15	22.60	deleterious	0.16	0.45	NA	NA	0.14	neutral	0.37	neutral	0.23	neutral	5	0.02	neutral	0.93	deleterious	-6	neutral	0.47	deleterious	0.28	medium_impact	0.83	medium_impact	-0.72	medium_impact	0.23	0.8	19.61	20.92	0.3	N	0.30	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10958	10958	A	G	MI.16744	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	199	67	M	V	Ata/Gta	-3.63	0	0	benign	0.08	neutral	1	neutral	1.71	neutral	1.73	neutral	1.14	neutral_impact	-1.02	0.67	neutral	0.98	neutral	-0.14	1.47	neutral	0.16	0.45	NA	NA	0.03	neutral	0.31	neutral	0.16	neutral	7	0.08	neutral	0.96	deleterious	-6	neutral	0.51	deleterious	0.28	medium_impact	1.88	high_impact	-2.14	low_impact	0.24	0.8	19.61	20.92	0.36	N	0.31	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10958	10958	A	C	MI.16745	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	199	67	M	L	Ata/Cta	-3.63	0	0	benign	0.08	neutral	0.93	neutral	1.77	neutral	2.55	neutral	0.15	neutral_impact	0.41	0.79	neutral	0.8	neutral	3.05	22.40	deleterious	0.16	0.45	NA	NA	0.14	neutral	0.37	neutral	0.23	neutral	5	0.02	neutral	0.93	deleterious	-6	neutral	0.47	deleterious	0.28	medium_impact	0.83	medium_impact	-0.72	medium_impact	0.23	0.8	19.61	20.92	0.3	N	0.30	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10959	10959	T	C	MI.16746	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	200	67	M	T	aTa/aCa	0.29	0	0	benign	0.01	neutral	0.15	neutral	1.57	neutral	-0.22	neutral	-1.2	neutral_impact	-0.41	0.73	neutral	0.99	neutral	1.59	13.77	neutral	0.1	0.4	NA	NA	0.11	neutral	0.38	neutral	0.23	neutral	5	0.85	neutral	0.57	deleterious	-6	neutral	0.62	deleterious	1.16	medium_impact	-0.22	medium_impact	-1.53	low_impact	0.18	0.8	19.61	20.92	0.51	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10959	10959	T	A	MI.16747	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	200	67	M	K	aTa/aAa	0.29	0	0	benign	0.27	deleterious	0.02	neutral	1.5	neutral	-1.79	deleterious	-2.71	low_impact	1.38	0.65	neutral	0.49	neutral	3.96	23.60	deleterious	0.04	0.35	NA	NA	0.33	neutral	0.62	disease	0.37	neutral	3	0.98	neutral	0.38	neutral	-2	neutral	0.69	deleterious	-0.31	medium_impact	-0.75	medium_impact	0.24	medium_impact	0.21	0.8	19.61	20.92	0.37	N	0.79	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10960	10960	A	T	MI.16748	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	201	67	M	I	atA/atT	0.06	0	0	benign	0.03	neutral	0.88	neutral	1.73	neutral	1.13	neutral	1.28	neutral_impact	-0.9	0.7	neutral	0.98	neutral	0.67	8.66	deleterious	0.19	0.45	NA	NA	0.05	neutral	0.28	neutral	0.12	neutral	8	0.06	neutral	0.93	deleterious	-6	neutral	0.58	deleterious	0.7	medium_impact	0.69	medium_impact	-2.02	low_impact	0.22	0.8	19.61	20.92	0.36	N	0.09	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10960	10960	A	C	MI.16749	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	201	67	M	I	atA/atC	0.06	0	0	benign	0.03	neutral	0.88	neutral	1.73	neutral	1.13	neutral	1.28	neutral_impact	-0.9	0.7	neutral	0.98	neutral	0.63	8.33	deleterious	0.19	0.45	NA	NA	0.05	neutral	0.28	neutral	0.12	neutral	8	0.06	neutral	0.93	deleterious	-6	neutral	0.58	deleterious	0.7	medium_impact	0.69	medium_impact	-2.02	low_impact	0.22	0.8	19.61	20.92	0.35	N	0.09	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8474	8474	C	T	MI.1675	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	109	37	P	S	Ccc/Tcc	-0.1	0	0	probably_damaging	1	neutral	0.37	neutral	2.05	deleterious	-3.41	deleterious	-5.23	medium_impact	2.88	1	neutral	0.6	neutral	3.87	23.50	deleterious	0.60673599	0.85	0.79	disease	0.17	neutral	0.57	disease	0.2	neutral	6	1	deleterious	0.19	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.16	medium_impact	1.37	medium_impact	0.38	0.85	NA	NA	0.53	N	0.65	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10961	10961	C	G	MI.16750	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	202	68	L	V	Cta/Gta	-10.32	0	0	possibly_damaging	0.86	deleterious	0.04	neutral	-0.39	deleterious	-6.15	neutral	-2.3	high_impact	3.56	0.51	damaging	0.51	neutral	3.27	22.80	deleterious	0.22	0.45	NA	NA	0.21	neutral	0.67	disease	0.38	neutral	2	0.98	neutral	0.09	neutral	5	deleterious	0.75	deleterious	-1.46	low_impact	-0.57	medium_impact	2.4	high_impact	0.33	0.8	45.75	8.94	0.51	P	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10961	10961	C	A	MI.16751	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	202	68	L	M	Cta/Ata	-10.32	0	0	possibly_damaging	0.68	neutral	0.09	neutral	-0.39	deleterious	-6.03	neutral	-1.53	medium_impact	2.87	0.51	damaging	0.61	neutral	3.59	23.20	deleterious	0.18	0.45	NA	NA	0.24	neutral	0.6	disease	0.37	neutral	3	0.92	neutral	0.21	neutral	0	NA	0.73	deleterious	-1.03	low_impact	-0.36	medium_impact	1.71	medium_impact	0.33	0.8	45.75	8.94	0.48	P	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10962	10962	T	G	MI.16752	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	203	68	L	R	cTa/cGa	-1.78	0	0	probably_damaging	0.98	deleterious	0	neutral	-0.45	deleterious	-9.42	deleterious	-4.59	high_impact	3.56	0.53	damaging	0.38	neutral	4.02	23.60	deleterious	0.03	0.35	NA	NA	0.61	disease	0.78	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.31	low_impact	-1.48	low_impact	2.4	high_impact	0.09	0.8	45.75	8.94	0.48	N	1.00	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10962	10962	T	C	MI.16753	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	203	68	L	P	cTa/cCa	-1.78	0	0	probably_damaging	0.99	deleterious	0	neutral	-0.45	deleterious	-9.9	deleterious	-5.36	high_impact	3.56	0.48	damaging	0.45	neutral	3.81	23.40	deleterious	0.03	0.35	NA	NA	0.46	neutral	0.79	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.59	low_impact	-1.48	low_impact	2.4	high_impact	0.28	0.8	45.75	8.94	0.48	N	0.98	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10962	10962	T	A	MI.16754	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	203	68	L	Q	cTa/cAa	-1.78	0	0	probably_damaging	0.98	deleterious	0	neutral	-0.45	deleterious	-9.34	deleterious	-4.59	high_impact	3.56	0.52	damaging	0.44	neutral	4.04	23.70	deleterious	0.04	0.35	NA	NA	0.49	neutral	0.68	disease	0.58	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.31	low_impact	-1.48	low_impact	2.4	high_impact	0.19	0.8	45.75	8.94	0.46	N	0.99	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10964	10964	A	C	MI.16755	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	205	69	T	P	Act/Cct	-3.63	0	0	probably_damaging	0.94	deleterious	0.04	neutral	1.23	deleterious	-4.56	deleterious	-4.2	medium_impact	3.41	0.67	neutral	0.37	neutral	3.35	22.90	deleterious	0.06	0.35	NA	NA	0.68	disease	0.75	disease	0.75	disease	5	0.99	deleterious	0.05	neutral	5	deleterious	0.79	deleterious	-1.84	low_impact	-0.57	medium_impact	2.25	high_impact	0.29	0.8	16.99	20.84	0.4	N	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10964	10964	A	T	MI.16756	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	205	69	T	S	Act/Tct	-3.63	0	0	benign	0.2	neutral	1	neutral	2.31	neutral	1.96	neutral	-2.39	low_impact	1.65	0.73	neutral	0.75	neutral	1.81	15.03	deleterious	0.37	0.5	NA	NA	0.03	neutral	0.32	neutral	0.14	neutral	7	0.2	neutral	0.9	deleterious	-6	neutral	0.67	deleterious	-0.15	medium_impact	1.88	high_impact	0.51	medium_impact	0.34	0.8	16.99	20.84	0.34	N	0.39	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10964	10964	A	G	MI.16757	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	205	69	T	A	Act/Gct	-3.63	0	0	possibly_damaging	0.64	deleterious	0	neutral	1.3	neutral	-2.27	deleterious	-3.33	medium_impact	3.06	0.76	neutral	0.72	neutral	3.35	22.90	deleterious	0.26	0.45	NA	NA	0.29	neutral	0.6	disease	0.39	neutral	2	1	deleterious	0.18	neutral	4	deleterious	0.71	deleterious	-0.95	medium_impact	-1.48	low_impact	1.9	medium_impact	0.23	0.8	16.99	20.84	0.45	N	0.86	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10965	10965	C	T	MI.16758	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	206	69	T	I	aCt/aTt	0.52	0.05	0	probably_damaging	0.96	deleterious	0	neutral	1.22	deleterious	-5.08	deleterious	-4.29	medium_impact	3.41	0.75	neutral	0.53	neutral	3.71	23.30	deleterious	0.15	0.4	NA	NA	0.53	disease	0.58	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.75	deleterious	-2.01	low_impact	-1.48	low_impact	2.25	high_impact	0.52	0.8	16.99	20.84	0.46	N	0.91	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10965	10965	C	G	MI.16759	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	206	69	T	S	aCt/aGt	0.52	0.05	0	benign	0.2	neutral	1	neutral	2.31	neutral	1.96	neutral	-2.39	low_impact	1.65	0.73	neutral	0.75	neutral	1.94	15.84	deleterious	0.37	0.5	NA	NA	0.03	neutral	0.32	neutral	0.14	neutral	7	0.2	neutral	0.9	deleterious	-6	neutral	0.67	deleterious	-0.15	medium_impact	1.88	high_impact	0.51	medium_impact	0.34	0.8	16.99	20.84	0.37	N	0.39	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8474	8474	C	A	MI.1676	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	109	37	P	T	Ccc/Acc	-0.1	0	0	probably_damaging	1	neutral	0.28	neutral	1.86	deleterious	-3.9	deleterious	-5.42	medium_impact	2.19	0.99	neutral	0.66	neutral	2.62	20.30	deleterious	0.66698427	0.85	0.83	disease	0.17	neutral	0.43	neutral	0.07	neutral	9	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.06	medium_impact	0.78	medium_impact	0.57	0.85	NA	NA	0.52	P	0.55	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10965	10965	C	A	MI.16760	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	206	69	T	N	aCt/aAt	0.52	0.05	0	possibly_damaging	0.83	deleterious	0.01	neutral	1.23	deleterious	-4.27	deleterious	-3.35	medium_impact	3.41	0.72	neutral	0.48	neutral	3.57	23.10	deleterious	0.3	0.45	NA	NA	0.52	disease	0.64	disease	0.67	disease	3	0.99	deleterious	0.09	neutral	4	deleterious	0.74	deleterious	-1.37	low_impact	-0.92	medium_impact	2.25	high_impact	0.39	0.8	16.99	20.84	0.44	N	0.83	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10967	10967	A	T	MI.16761	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	208	70	T	S	Acc/Tcc	-11.93	0	0	benign	0.27	neutral	0.07	neutral	1.55	neutral	-0.71	neutral	-1.05	medium_impact	2.29	0.82	neutral	0.83	neutral	3.65	23.20	deleterious	0.47	0.55	NA	NA	0.27	neutral	0.52	disease	0.32	neutral	4	0.92	neutral	0.4	neutral	-3	neutral	0.70	deleterious	-0.31	medium_impact	-0.43	medium_impact	1.14	medium_impact	0.40	0.8	33.33	28.4	0.45	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10967	10967	A	G	MI.16762	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	208	70	T	A	Acc/Gcc	-11.93	0	0	benign	0.01	neutral	0.39	neutral	1.62	neutral	0.47	neutral	-0.97	low_impact	1.32	0.75	neutral	0.97	neutral	2.68	20.70	deleterious	0.3	0.45	NA	NA	0.21	neutral	0.37	neutral	0.18	neutral	6	0.6	neutral	0.69	deleterious	-6	neutral	0.70	deleterious	1.16	medium_impact	0.09	medium_impact	0.18	medium_impact	0.26	0.8	33.33	28.4	0.43	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10967	10967	A	C	MI.16763	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	208	70	T	P	Acc/Ccc	-11.93	0	0	possibly_damaging	0.66	deleterious	0.03	neutral	1.51	neutral	-2.41	deleterious	-2.6	medium_impact	2.64	0.65	neutral	0.41	neutral	3.83	23.40	deleterious	0.06	0.35	NA	NA	0.74	disease	0.7	disease	0.77	disease	5	0.97	neutral	0.19	neutral	4	deleterious	0.79	deleterious	-0.99	medium_impact	-0.64	medium_impact	1.49	medium_impact	0.31	0.8	33.33	28.4	0.37	N	0.55	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10968	10968	C	G	MI.16764	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	209	70	T	S	aCc/aGc	0.29	0	0	benign	0.27	neutral	0.07	neutral	1.55	neutral	-0.71	neutral	-1.05	medium_impact	2.29	0.82	neutral	0.83	neutral	3.34	22.90	deleterious	0.47	0.55	NA	NA	0.27	neutral	0.52	disease	0.32	neutral	4	0.92	neutral	0.4	neutral	-3	neutral	0.70	deleterious	-0.31	medium_impact	-0.43	medium_impact	1.14	medium_impact	0.40	0.8	33.33	28.4	0.45	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10968	10968	C	T	MI.16765	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	209	70	T	I	aCc/aTc	0.29	0	0	benign	0.02	neutral	0.55	neutral	1.67	neutral	0.99	neutral	-1.74	medium_impact	1.95	0.76	neutral	0.79	neutral	3.76	23.30	deleterious	0.16	0.45	NA	NA	0.4	neutral	0.4	neutral	0.14	neutral	7	0.42	neutral	0.77	deleterious	-3	neutral	0.73	deleterious	0.87	medium_impact	0.25	medium_impact	0.8	medium_impact	0.44	0.8	33.33	28.4	0.32	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10968	10968	C	A	MI.16766	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	209	70	T	N	aCc/aAc	0.29	0	0	possibly_damaging	0.73	deleterious	0.03	neutral	1.52	neutral	-2.1	neutral	-2.3	medium_impact	2.64	0.68	neutral	0.58	neutral	3.54	23.10	deleterious	0.31	0.45	NA	NA	0.54	disease	0.58	disease	0.71	disease	4	0.98	neutral	0.15	neutral	4	deleterious	0.74	deleterious	-1.12	low_impact	-0.64	medium_impact	1.49	medium_impact	0.44	0.8	33.33	28.4	0.41	N	0.40	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10970	10970	T	C	MI.16767	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	211	71	W	R	Tga/Cga	-2.48	0	0	probably_damaging	0.97	deleterious	0	neutral	0.14	deleterious	-7.47	deleterious	-10.74	high_impact	3.54	0.57	damaging	0.06	damaging	3.42	23.00	deleterious	0.08	0.35	NA	NA	0.75	disease	0.82	disease	0.77	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.14	low_impact	-1.48	low_impact	2.38	high_impact	0.17	0.8	47.28	9.24	0.4	N	0.97	polymorphism	1	0.23	.	.	.	.	.	pancreatic cancer cell line	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10970	10970	T	G	MI.16768	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	211	71	W	G	Tga/Gga	-2.48	0	0	possibly_damaging	0.81	deleterious	0	neutral	0.13	deleterious	-8.07	deleterious	-9.97	high_impact	3.54	0.53	damaging	0.09	damaging	3.81	23.40	deleterious	0.1	0.4	NA	NA	0.61	disease	0.78	disease	0.74	disease	5	1	deleterious	0.1	neutral	5	deleterious	0.77	deleterious	-1.31	low_impact	-1.48	low_impact	2.38	high_impact	0.20	0.8	47.28	9.24	0.38	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10971	10971	G	T	MI.16769	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	212	71	W	L	tGa/tTa	5.6	1	0	probably_damaging	0.91	neutral	0.09	neutral	0.23	deleterious	-4.45	deleterious	-9.97	high_impact	3.54	0.52	damaging	0.06	damaging	4.12	23.80	deleterious	0.11	0.4	NA	NA	0.64	disease	0.74	disease	0.72	disease	4	0.97	neutral	0.09	neutral	2	deleterious	0.78	deleterious	-1.66	low_impact	-0.36	medium_impact	2.38	high_impact	0.13	0.8	47.28	9.24	0.58	P	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8475	8475	C	T	MI.1677	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	110	37	P	L	cCc/cTc	0.82	0	0	probably_damaging	1	neutral	0.17	neutral	1.85	deleterious	-4.7	deleterious	-6.83	medium_impact	2.58	0.99	neutral	0.67	neutral	4.38	24.10	deleterious	0.63281019	0.85	0.87	disease	0.21	neutral	0.45	neutral	0.16	neutral	7	1	deleterious	0.09	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.1	medium_impact	1.11	medium_impact	0.64	0.85	NA	NA	0.56	P	0.86	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10971	10971	G	C	MI.16770	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	212	71	W	S	tGa/tCa	5.6	1	0	benign	0.34	deleterious	0	neutral	0.14	deleterious	-7.27	deleterious	-10.74	high_impact	3.54	0.5	damaging	0.1	damaging	3.89	23.50	deleterious	0.08	0.35	NA	NA	0.69	disease	0.76	disease	0.75	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-0.45	medium_impact	-1.48	low_impact	2.38	high_impact	0.15	0.8	47.28	9.24	0.49	P	0.93	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10972	10972	A	T	MI.16771	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	213	71	W	C	tgA/tgT	9.05	1	0	probably_damaging	0.99	deleterious	0	neutral	0.13	deleterious	-8.81	deleterious	-9.97	high_impact	3.54	0.49	damaging	0.05	damaging	4.00	23.60	deleterious	0.1	0.4	NA	NA	0.68	disease	0.8	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.59	low_impact	-1.48	low_impact	2.38	high_impact	0.14	0.8	47.28	9.24	0.53	P	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10972	10972	A	C	MI.16772	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	213	71	W	C	tgA/tgC	9.05	1	0	probably_damaging	0.99	deleterious	0	neutral	0.13	deleterious	-8.81	deleterious	-9.97	high_impact	3.54	0.49	damaging	0.05	damaging	3.87	23.50	deleterious	0.1	0.4	NA	NA	0.68	disease	0.8	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.59	low_impact	-1.48	low_impact	2.38	high_impact	0.14	0.8	47.28	9.24	0.53	P	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10973	10973	C	T	MI.16773	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	214	72	L	F	Ctc/Ttc	1.44	1	0	benign	0.17	deleterious	0.01	neutral	0.91	deleterious	-4.78	deleterious	-3.06	medium_impact	3.5	0.66	neutral	0.62	neutral	3.90	23.50	deleterious	0.21	0.45	NA	NA	0.37	neutral	0.62	disease	0.39	neutral	2	0.99	deleterious	0.42	neutral	1	deleterious	0.76	deleterious	-0.07	medium_impact	-0.92	medium_impact	2.34	high_impact	0.33	0.8	47.28	9.32	0.52	P	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10973	10973	C	A	MI.16774	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	214	72	L	I	Ctc/Atc	1.44	1	0	benign	0.12	neutral	0.53	neutral	1.38	neutral	-0.62	neutral	-1.53	medium_impact	2.4	0.71	neutral	0.6	neutral	3.96	23.60	deleterious	0.21	0.45	NA	NA	0.13	neutral	0.42	neutral	0.22	neutral	6	0.38	neutral	0.71	deleterious	-3	neutral	0.72	deleterious	0.1	medium_impact	0.23	medium_impact	1.25	medium_impact	0.33	0.8	47.28	9.32	0.52	P	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10973	10973	C	G	MI.16775	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	214	72	L	V	Ctc/Gtc	1.44	1	0	possibly_damaging	0.52	neutral	0.12	neutral	1.09	neutral	-2.05	neutral	-2.3	medium_impact	3.15	0.72	neutral	0.52	neutral	3.32	22.90	deleterious	0.2	0.45	NA	NA	0.27	neutral	0.65	disease	0.38	neutral	2	0.87	neutral	0.3	neutral	0	NA	0.74	deleterious	-0.75	medium_impact	-0.28	medium_impact	1.99	medium_impact	0.41	0.8	47.28	9.32	0.61	P	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10974	10974	T	G	MI.16776	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	215	72	L	R	cTc/cGc	0.98	1	0	probably_damaging	0.97	deleterious	0	neutral	0.89	deleterious	-6.65	deleterious	-4.6	medium_impact	3.5	0.65	neutral	0.38	neutral	4.11	23.70	deleterious	0.04	0.35	NA	NA	0.72	disease	0.77	disease	0.75	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-2.14	low_impact	-1.48	low_impact	2.34	high_impact	0.13	0.8	47.28	9.32	0.49	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10974	10974	T	A	MI.16777	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	215	72	L	H	cTc/cAc	0.98	1	0	probably_damaging	0.98	deleterious	0	neutral	0.89	deleterious	-7.37	deleterious	-5.37	medium_impact	3.5	0.69	neutral	0.4	neutral	4.22	23.90	deleterious	0.07	0.35	NA	NA	0.59	disease	0.75	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.31	low_impact	-1.48	low_impact	2.34	high_impact	0.23	0.8	47.28	9.32	0.47	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10974	10974	T	C	MI.16778	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	215	72	L	P	cTc/cCc	0.98	1	0	probably_damaging	0.98	deleterious	0	neutral	0.89	deleterious	-7.02	deleterious	-5.37	medium_impact	3.5	0.64	neutral	0.44	neutral	3.84	23.40	deleterious	0.04	0.35	NA	NA	0.63	disease	0.77	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-2.31	low_impact	-1.48	low_impact	2.34	high_impact	0.28	0.8	47.28	9.32	0.48	N	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10976	10976	C	G	MI.16779	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	217	73	L	V	Cta/Gta	-20	0	0.05	possibly_damaging	0.76	neutral	0.21	neutral	1.36	neutral	-1.39	neutral	-2.22	medium_impact	3.5	0.68	neutral	0.12	damaging	3.29	22.80	deleterious	0.33	0.5	NA	NA	0.29	neutral	0.5	neutral	0.19	neutral	6	0.86	neutral	0.23	neutral	0	NA	0.73	deleterious	-1.19	low_impact	-0.12	medium_impact	2.34	high_impact	0.31	0.8	45.97	8.88	0.37	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8475	8475	C	A	MI.1678	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	110	37	P	H	cCc/cAc	0.82	0	0	probably_damaging	1	neutral	0.05	neutral	1.78	deleterious	-5.42	deleterious	-6.25	high_impact	3.77	0.98	neutral	0.37	neutral	4.01	23.60	deleterious	0.44957237	0.85	0.93	disease	0.23	neutral	0.61	disease	0.16	neutral	7	1	deleterious	0.03	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.43	medium_impact	2.13	high_impact	0.63	0.85	NA	NA	0.53	P	0.82	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10976	10976	C	A	MI.16780	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	217	73	L	M	Cta/Ata	-20	0	0.05	probably_damaging	0.98	neutral	0.11	neutral	1.27	neutral	-2.55	neutral	-1.49	medium_impact	3.5	0.72	neutral	0.16	damaging	3.62	23.20	deleterious	0.24	0.45	NA	NA	0.29	neutral	0.49	neutral	0.19	neutral	6	0.99	deleterious	0.07	neutral	1	deleterious	0.71	deleterious	-2.31	low_impact	-0.31	medium_impact	2.34	high_impact	0.36	0.8	45.97	8.88	0.42	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10977	10977	T	A	MI.16781	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	218	73	L	Q	cTa/cAa	0.29	0.02	0	probably_damaging	1	deleterious	0.03	neutral	1.22	deleterious	-4.19	deleterious	-4.49	medium_impact	3.5	0.68	neutral	0.12	damaging	3.94	23.50	deleterious	0.08	0.35	NA	NA	0.59	disease	0.59	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-3.54	low_impact	-0.64	medium_impact	2.34	high_impact	0.18	0.8	45.97	8.88	0.35	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10977	10977	T	C	MI.16782	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	218	73	L	P	cTa/cCa	0.29	0.02	0	probably_damaging	1	deleterious	0.02	neutral	1.22	deleterious	-4.64	deleterious	-5.24	medium_impact	3.5	0.58	damaging	0.12	damaging	3.78	23.40	deleterious	0.04	0.35	NA	NA	0.68	disease	0.71	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.75	medium_impact	2.34	high_impact	0.28	0.8	45.97	8.88	0.3	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10977	10977	T	G	MI.16783	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	218	73	L	R	cTa/cGa	0.29	0.02	0	probably_damaging	1	deleterious	0.03	neutral	1.23	deleterious	-4.03	deleterious	-4.49	medium_impact	3.5	0.57	damaging	0.11	damaging	4.07	23.70	deleterious	0.05	0.35	NA	NA	0.74	disease	0.71	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-3.54	low_impact	-0.64	medium_impact	2.34	high_impact	0.18	0.8	45.97	8.88	0.31	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10979	10979	C	G	MI.16784	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	220	74	P	A	Ccc/Gcc	-15.85	0	0	benign	0.12	neutral	0.24	neutral	1.37	neutral	-1.48	deleterious	-6.18	medium_impact	2.42	0.7	neutral	0.52	neutral	2.95	22.10	deleterious	0.22	0.45	NA	NA	0.42	neutral	0.59	disease	0.35	neutral	3	0.72	neutral	0.56	deleterious	-3	neutral	0.75	deleterious	0.1	medium_impact	-0.08	medium_impact	1.27	medium_impact	0.68	0.85	47.28	9.38	0.45	N	0.77	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10979	10979	C	A	MI.16785	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	220	74	P	T	Ccc/Acc	-15.85	0	0	possibly_damaging	0.83	neutral	0.15	neutral	1.31	neutral	-2.47	deleterious	-6.18	medium_impact	3.47	0.66	neutral	0.42	neutral	3.56	23.10	deleterious	0.22	0.45	NA	NA	0.57	disease	0.64	disease	0.65	disease	3	0.92	neutral	0.16	neutral	0	NA	0.75	deleterious	-1.37	low_impact	-0.22	medium_impact	2.31	high_impact	0.48	0.8	47.28	9.38	0.43	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10979	10979	C	T	MI.16786	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	220	74	P	S	Ccc/Tcc	-15.85	0	0	possibly_damaging	0.83	neutral	0.25	neutral	1.37	neutral	-1.52	deleterious	-6.18	medium_impact	2.57	0.68	neutral	0.48	neutral	3.76	23.40	deleterious	0.23	0.45	NA	NA	0.52	disease	0.62	disease	0.47	neutral	1	0.88	neutral	0.21	neutral	0	NA	0.77	deleterious	-1.37	low_impact	-0.07	medium_impact	1.42	medium_impact	0.13	0.8	47.28	9.38	0.42	N	0.71	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10980	10980	C	A	MI.16787	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	221	74	P	H	cCc/cAc	5.6	1	0	probably_damaging	0.98	neutral	0.15	neutral	1.26	deleterious	-4.17	deleterious	-6.95	medium_impact	3.47	0.65	neutral	0.35	neutral	4.00	23.60	deleterious	0.11	0.4	NA	NA	0.75	disease	0.74	disease	0.74	disease	5	0.99	deleterious	0.09	neutral	1	deleterious	0.80	deleterious	-2.31	low_impact	-0.22	medium_impact	2.31	high_impact	0.30	0.8	47.28	9.38	0.6	P	0.70	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10980	10980	C	T	MI.16788	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	221	74	P	L	cCc/cTc	5.6	1	0	possibly_damaging	0.48	neutral	0.26	neutral	1.36	neutral	-1.68	deleterious	-7.72	medium_impact	3.12	0.66	neutral	0.43	neutral	4.22	23.90	deleterious	0.11	0.4	NA	NA	0.73	disease	0.61	disease	0.57	disease	1	0.71	neutral	0.39	neutral	0	NA	0.79	deleterious	-0.69	medium_impact	-0.05	medium_impact	1.96	medium_impact	0.52	0.8	47.28	9.38	0.67	P	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10980	10980	C	G	MI.16789	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	221	74	P	R	cCc/cGc	5.6	1	0	probably_damaging	0.96	neutral	0.09	neutral	1.28	deleterious	-3.36	deleterious	-6.95	medium_impact	3.47	0.64	neutral	0.42	neutral	3.47	23.10	deleterious	0.07	0.35	NA	NA	0.79	disease	0.74	disease	0.75	disease	5	0.98	deleterious	0.07	neutral	1	deleterious	0.84	deleterious	-2.01	low_impact	-0.36	medium_impact	2.31	high_impact	0.37	0.8	47.28	9.38	0.61	P	0.58	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8475	8475	C	G	MI.1679	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	110	37	P	R	cCc/cGc	0.82	0	0	probably_damaging	1	neutral	0.19	neutral	1.79	deleterious	-4.32	deleterious	-6.43	high_impact	3.77	1	neutral	0.33	neutral	3.59	23.20	deleterious	0.50472207	0.85	0.88	disease	0.25	neutral	0.63	disease	0.15	neutral	7	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.06	medium_impact	2.13	high_impact	0.55	0.85	NA	NA	0.52	N	0.87	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10982	10982	C	T	MI.16790	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	223	75	L	F	Ctc/Ttc	-7.55	0	0	benign	0.17	deleterious	0	neutral	0.11	deleterious	-5.98	deleterious	-3	high_impact	3.52	0.63	neutral	0.45	neutral	3.84	23.40	deleterious	0.17	0.45	NA	NA	0.46	neutral	0.67	disease	0.45	neutral	1	1	deleterious	0.42	neutral	2	deleterious	0.77	deleterious	-0.07	medium_impact	-1.48	low_impact	2.36	high_impact	0.54	0.8	47.06	9.34	0.43	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10982	10982	C	G	MI.16791	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	223	75	L	V	Ctc/Gtc	-7.55	0	0	possibly_damaging	0.74	neutral	0.07	neutral	0.16	deleterious	-4.81	neutral	-2.23	medium_impact	3.18	0.66	neutral	0.59	neutral	3.32	22.90	deleterious	0.25	0.45	NA	NA	0.38	neutral	0.61	disease	0.37	neutral	3	0.95	neutral	0.17	neutral	0	NA	0.76	deleterious	-1.14	low_impact	-0.43	medium_impact	2.02	high_impact	0.49	0.8	47.06	9.34	0.45	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10982	10982	C	A	MI.16792	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	223	75	L	I	Ctc/Atc	-7.55	0	0	possibly_damaging	0.74	neutral	0.12	neutral	0.19	deleterious	-4.42	neutral	-1.5	medium_impact	3.18	0.65	neutral	0.57	neutral	3.96	23.60	deleterious	0.33	0.5	NA	NA	0.43	neutral	0.57	disease	0.38	neutral	2	0.91	neutral	0.19	neutral	0	NA	0.76	deleterious	-1.14	low_impact	-0.28	medium_impact	2.02	high_impact	0.49	0.8	47.06	9.34	0.49	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10983	10983	T	A	MI.16793	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	224	75	L	H	cTc/cAc	-2.01	0	0	probably_damaging	0.98	deleterious	0	neutral	0.07	deleterious	-9.14	deleterious	-5.28	high_impact	3.52	0.62	neutral	0.38	neutral	3.99	23.60	deleterious	0.06	0.35	NA	NA	0.68	disease	0.74	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.31	low_impact	-1.48	low_impact	2.36	high_impact	0.23	0.8	47.06	9.34	0.36	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10983	10983	T	C	MI.16794	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	224	75	L	P	cTc/cCc	-2.01	0	0	probably_damaging	0.97	deleterious	0	neutral	0.08	deleterious	-7.74	deleterious	-5.29	medium_impact	2.98	0.6	damaging	0.5	neutral	3.79	23.40	deleterious	0.04	0.35	NA	NA	0.68	disease	0.77	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-2.14	low_impact	-1.48	low_impact	1.82	medium_impact	0.26	0.8	47.06	9.34	0.38	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10983	10983	T	G	MI.16795	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	224	75	L	R	cTc/cGc	-2.01	0	0	probably_damaging	0.96	deleterious	0	neutral	0.08	deleterious	-8.37	deleterious	-4.51	high_impact	3.52	0.65	neutral	0.36	neutral	4.07	23.70	deleterious	0.03	0.35	NA	NA	0.77	disease	0.77	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-2.01	low_impact	-1.48	low_impact	2.36	high_impact	0.12	0.8	47.06	9.34	0.43	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10985	10985	A	G	MI.16796	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	226	76	T	A	Aca/Gca	-5.01	0	0	benign	0.07	neutral	0.05	neutral	1.56	neutral	-0.35	neutral	-0.46	low_impact	0.8	0.71	neutral	0.85	neutral	1.46	13.12	neutral	0.29	0.45	NA	NA	0.37	neutral	0.5	neutral	0.15	neutral	7	0.95	neutral	0.49	deleterious	-6	neutral	0.19	neutral	0.34	medium_impact	-0.52	medium_impact	-0.33	medium_impact	0.29	0.8	41.83	8.12	0.46	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10985	10985	A	C	MI.16797	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	226	76	T	P	Aca/Cca	-5.01	0	0	possibly_damaging	0.45	deleterious	0	neutral	1.48	neutral	-2.84	neutral	-1.24	low_impact	1.15	0.66	neutral	0.47	neutral	1.74	14.65	neutral	0.04	0.35	NA	NA	0.82	disease	0.7	disease	0.79	disease	6	1	deleterious	0.28	neutral	1	deleterious	0.58	deleterious	-0.64	medium_impact	-1.48	low_impact	0.01	medium_impact	0.28	0.8	41.83	8.12	0.33	N	0.29	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10985	10985	A	T	MI.16798	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	226	76	T	S	Aca/Tca	-5.01	0	0	benign	0.2	neutral	0.1	neutral	1.55	neutral	-0.45	neutral	-0.37	neutral_impact	0.6	0.68	neutral	0.64	neutral	1.34	12.47	neutral	0.4	0.5	NA	NA	0.38	neutral	0.36	neutral	0.15	neutral	7	0.88	neutral	0.45	neutral	-6	neutral	0.24	neutral	-0.15	medium_impact	-0.33	medium_impact	-0.53	medium_impact	0.52	0.8	41.83	8.12	0.47	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10986	10986	C	A	MI.16799	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	227	76	T	K	aCa/aAa	8.59	1	0	benign	0.15	deleterious	0.01	neutral	1.5	neutral	-1.93	neutral	-0.56	low_impact	1.15	0.73	neutral	0.56	neutral	2.51	19.50	deleterious	0.07	0.35	NA	NA	0.7	disease	0.68	disease	0.74	disease	5	0.99	deleterious	0.43	neutral	-2	neutral	0.30	neutral	-0.01	medium_impact	-0.92	medium_impact	0.01	medium_impact	0.38	0.8	41.83	8.12	0.56	P	0.35	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8604	8604	T	G	MI.168	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	78	26	F	L	ttT/ttG	3.83	0.39	0	benign	0	neutral	1	neutral	4.49	neutral	0.67	neutral	-1.96	neutral_impact	-0.38	0.96	neutral	0.92	neutral	-0.42	0.34	neutral	0.42	0.65	0.29	neutral	0.15	neutral	0.27	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.98	high_impact	-1.42	low_impact	0.39	0.9	15.49	8.03	0.36	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8477	8477	T	A	MI.1680	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	112	38	S	T	Tca/Aca	-4.5	0	0	benign	0	neutral	0.85	neutral	1.6	neutral	0.28	neutral	-0.88	low_impact	0.82	1	neutral	0.94	neutral	-0.06	2.07	deleterious	0.74487615	0.85	0.31	neutral	0.21	neutral	0.22	neutral	0.24	neutral	5	0.15	neutral	0.93	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.72	medium_impact	-0.4	medium_impact	0.75	0.85	20.59	7.81	0.35	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10986	10986	C	T	MI.16800	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	227	76	T	M	aCa/aTa	8.59	1	0	benign	0.01	neutral	1	neutral	2.05	neutral	2.53	neutral	3.51	neutral_impact	-2.36	0.71	neutral	0.94	neutral	-0.77	0.05	neutral	0.12	0.4	NA	NA	0.08	neutral	0.27	neutral	0.18	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.16	medium_impact	1.88	high_impact	-3.46	low_impact	0.51	0.8	41.83	8.12	0.51	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10988	10988	A	G	MI.16801	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	229	77	I	V	Atc/Gtc	1.68	0.91	0	benign	0.05	neutral	0.17	neutral	1.45	neutral	-0.77	neutral	-0.71	medium_impact	2.06	0.74	neutral	0.75	neutral	2.86	21.70	deleterious	0.52	0.6	NA	NA	0.13	neutral	0.42	neutral	0.23	neutral	5	0.82	neutral	0.56	deleterious	-3	neutral	0.60	deleterious	0.48	medium_impact	-0.18	medium_impact	0.91	medium_impact	0.38	0.8	27.02	20.05	0.52	P	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10988	10988	A	T	MI.16802	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	229	77	I	F	Atc/Ttc	1.68	0.91	0	possibly_damaging	0.88	neutral	0.19	neutral	1.34	neutral	-2.04	deleterious	-2.55	medium_impact	2.4	0.74	neutral	0.69	neutral	3.80	23.40	deleterious	0.17	0.45	NA	NA	0.46	neutral	0.58	disease	0.42	neutral	2	0.93	neutral	0.16	neutral	0	NA	0.71	deleterious	-1.53	low_impact	-0.15	medium_impact	1.25	medium_impact	0.43	0.8	27.02	20.05	0.47	N	0.57	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10988	10988	A	C	MI.16803	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	229	77	I	L	Atc/Ctc	1.68	0.91	0	benign	0.18	neutral	0.44	neutral	1.58	neutral	-0.03	neutral	-0.56	neutral_impact	0.22	0.74	neutral	0.96	neutral	2.14	17.08	deleterious	0.22	0.45	NA	NA	0.17	neutral	0.33	neutral	0.2	neutral	6	0.47	neutral	0.63	deleterious	-6	neutral	0.62	deleterious	-0.1	medium_impact	0.14	medium_impact	-0.91	medium_impact	0.46	0.8	27.02	20.05	0.42	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10989	10989	T	A	MI.16804	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	230	77	I	N	aTc/aAc	-0.17	0.61	0	probably_damaging	0.91	deleterious	0	neutral	1.27	deleterious	-4.21	deleterious	-4.78	medium_impact	2.95	0.66	neutral	0.49	neutral	4.45	24.20	deleterious	0.09	0.4	NA	NA	0.62	disease	0.65	disease	0.69	disease	4	1	deleterious	0.05	neutral	5	deleterious	0.74	deleterious	-1.66	low_impact	-1.48	low_impact	1.79	medium_impact	0.14	0.8	27.02	20.05	0.38	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10989	10989	T	C	MI.16805	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	230	77	I	T	aTc/aCc	-0.17	0.61	0	benign	0.13	deleterious	0.01	neutral	1.32	neutral	-2.37	deleterious	-3.21	medium_impact	2.15	0.72	neutral	0.72	neutral	2.27	17.99	deleterious	0.12	0.4	NA	NA	0.34	neutral	0.56	disease	0.36	neutral	3	0.99	deleterious	0.44	neutral	1	deleterious	0.70	deleterious	0.06	medium_impact	-0.92	medium_impact	1	medium_impact	0.29	0.8	27.02	20.05	0.38	N	0.84	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10989	10989	T	G	MI.16806	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	230	77	I	S	aTc/aGc	-0.17	0.61	0	possibly_damaging	0.76	deleterious	0.01	neutral	1.3	neutral	-2.88	deleterious	-4.01	medium_impact	2.95	0.71	neutral	0.55	neutral	4.15	23.80	deleterious	0.04	0.35	NA	NA	0.61	disease	0.62	disease	0.68	disease	4	0.99	deleterious	0.13	neutral	4	deleterious	0.73	deleterious	-1.19	low_impact	-0.92	medium_impact	1.79	medium_impact	0.16	0.8	27.02	20.05	0.35	N	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10990	10990	C	A	MI.16807	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	231	77	I	M	atC/atA	7.44	0.98	0	benign	0.4	neutral	0.21	neutral	1.35	neutral	-1.84	neutral	-1.48	medium_impact	2.6	0.77	neutral	0.94	neutral	2.64	20.40	deleterious	0.3	0.45	NA	NA	0.23	neutral	0.4	neutral	0.17	neutral	7	0.75	neutral	0.41	neutral	-3	neutral	0.69	deleterious	-0.55	medium_impact	-0.12	medium_impact	1.45	medium_impact	0.49	0.8	27.02	20.05	0.63	P	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10990	10990	C	G	MI.16808	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	231	77	I	M	atC/atG	7.44	0.98	0	benign	0.4	neutral	0.21	neutral	1.35	neutral	-1.84	neutral	-1.48	medium_impact	2.6	0.77	neutral	0.94	neutral	2.14	17.09	deleterious	0.3	0.45	NA	NA	0.23	neutral	0.4	neutral	0.17	neutral	7	0.75	neutral	0.41	neutral	-3	neutral	0.69	deleterious	-0.55	medium_impact	-0.12	medium_impact	1.45	medium_impact	0.49	0.8	27.02	20.05	0.63	P	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10991	10991	A	C	MI.16809	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	232	78	M	L	Atg/Ctg	-10.78	0	0	benign	0.02	neutral	1	neutral	1.76	neutral	2.59	neutral	0.15	neutral_impact	0.27	0.66	neutral	0.98	neutral	-1.30	0.01	neutral	0.23	0.45	NA	NA	0.11	neutral	0.4	neutral	0.18	neutral	6	0.02	neutral	0.99	deleterious	-6	neutral	0.11	neutral	0.87	medium_impact	1.88	high_impact	-0.86	medium_impact	0.31	0.8	25.71	18.27	0.4	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8477	8477	T	G	MI.1681	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	112	38	S	A	Tca/Gca	-4.5	0	0	benign	0.01	neutral	0.7	neutral	1.66	neutral	1.36	neutral	-1.18	medium_impact	2.27	1	neutral	0.85	neutral	-0.37	0.45	neutral	0.72936886	0.85	0.24	neutral	0.09	neutral	0.35	neutral	0.04	neutral	9	0.28	neutral	0.85	deleterious	-3	neutral	0.14	neutral	1.14	medium_impact	0.5	medium_impact	0.85	medium_impact	0.69	0.85	20.59	7.81	0.42	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10991	10991	A	G	MI.16810	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	232	78	M	V	Atg/Gtg	-10.78	0	0	benign	0.25	neutral	0.08	neutral	1.48	neutral	1.67	neutral	-0.84	medium_impact	2.47	0.78	neutral	0.82	neutral	0.80	9.48	deleterious	0.2	0.45	NA	NA	0.39	neutral	0.6	disease	0.38	neutral	2	0.91	neutral	0.42	neutral	-3	neutral	0.15	neutral	-0.27	medium_impact	-0.39	medium_impact	1.32	medium_impact	0.23	0.8	25.71	18.27	0.42	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10991	10991	A	T	MI.16811	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	232	78	M	L	Atg/Ttg	-10.78	0	0	benign	0.02	neutral	1	neutral	1.76	neutral	2.59	neutral	0.15	neutral_impact	0.27	0.66	neutral	0.98	neutral	-1.32	0.00	neutral	0.23	0.45	NA	NA	0.11	neutral	0.4	neutral	0.18	neutral	6	0.02	neutral	0.99	deleterious	-6	neutral	0.11	neutral	0.87	medium_impact	1.88	high_impact	-0.86	medium_impact	0.31	0.8	25.71	18.27	0.39	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10992	10992	T	A	MI.16812	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	233	78	M	K	aTg/aAg	-0.86	0	0	benign	0.36	deleterious	0	neutral	1.38	neutral	-1.92	deleterious	-3.55	medium_impact	2.82	0.68	neutral	0.47	neutral	2.10	16.87	deleterious	0.03	0.35	NA	NA	0.61	disease	0.71	disease	0.75	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.30	neutral	-0.48	medium_impact	-1.48	low_impact	1.66	medium_impact	0.12	0.8	25.71	18.27	0.38	N	0.90	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10992	10992	T	C	MI.16813	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	233	78	M	T	aTg/aCg	-0.86	0	0	benign	0.02	neutral	0.07	neutral	1.44	neutral	-0.1	deleterious	-2.79	medium_impact	2.82	0.78	neutral	0.81	neutral	-0.15	1.40	neutral	0.11	0.4	NA	NA	0.41	neutral	0.64	disease	0.37	neutral	3	0.93	neutral	0.53	deleterious	-3	neutral	0.14	neutral	0.87	medium_impact	-0.43	medium_impact	1.66	medium_impact	0.11	0.8	25.71	18.27	0.44	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10993	10993	G	C	MI.16814	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	234	78	M	I	atG/atC	5.83	0.88	0	benign	0.25	neutral	0.22	neutral	1.53	neutral	2	neutral	-0.32	low_impact	1.5	0.71	neutral	0.99	neutral	-0.10	1.72	neutral	0.25	0.45	NA	NA	0.26	neutral	0.45	neutral	0.18	neutral	6	0.74	neutral	0.49	deleterious	-6	neutral	0.19	neutral	-0.27	medium_impact	-0.11	medium_impact	0.36	medium_impact	0.31	0.8	25.71	18.27	0.57	P	0.30	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10993	10993	G	T	MI.16815	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	234	78	M	I	atG/atT	5.83	0.88	0	benign	0.25	neutral	0.22	neutral	1.53	neutral	2	neutral	-0.32	low_impact	1.5	0.71	neutral	0.99	neutral	0.00	2.58	deleterious	0.25	0.45	NA	NA	0.26	neutral	0.45	neutral	0.18	neutral	6	0.74	neutral	0.49	deleterious	-6	neutral	0.19	neutral	-0.27	medium_impact	-0.11	medium_impact	0.36	medium_impact	0.31	0.8	25.71	18.27	0.57	P	0.30	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10994	10994	G	C	MI.16816	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	235	79	A	P	Gca/Cca	-3.86	0	0	probably_damaging	1	deleterious	0	neutral	0.18	deleterious	-7.05	deleterious	-3.86	high_impact	3.55	0.76	neutral	0.43	neutral	3.70	23.30	deleterious	0.04	0.35	NA	NA	0.68	disease	0.81	disease	0.75	disease	5	1	deleterious	0	deleterious	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	2.39	high_impact	0.38	0.8	46.84	9.23	0.45	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10994	10994	G	A	MI.16817	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	235	79	A	T	Gca/Aca	-3.86	0	0	probably_damaging	1	deleterious	0	neutral	0.21	deleterious	-5.59	deleterious	-3.09	high_impact	3.55	0.66	neutral	0.45	neutral	4.11	23.70	deleterious	0.12	0.4	NA	NA	0.58	disease	0.71	disease	0.71	disease	4	1	deleterious	0	deleterious	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	2.39	high_impact	0.48	0.8	46.84	9.23	0.46	N	0.82	polymorphism	1	0.09	.	.	.	.	.	.	COSM6716761	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10994	10994	G	T	MI.16818	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	235	79	A	S	Gca/Tca	-3.86	0	0	probably_damaging	1	neutral	0.26	neutral	0.42	deleterious	-3.12	neutral	-2.32	high_impact	3.55	0.66	neutral	0.54	neutral	3.59	23.20	deleterious	0.2	0.45	NA	NA	0.49	neutral	0.65	disease	0.41	neutral	2	1	deleterious	0.13	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	-0.05	medium_impact	2.39	high_impact	0.27	0.8	46.84	9.23	0.5	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10995	10995	C	G	MI.16819	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	236	79	A	G	gCa/gGa	7.21	1	0	probably_damaging	1	deleterious	0.04	neutral	0.22	deleterious	-5.37	deleterious	-3.09	medium_impact	2.86	0.59	damaging	0.53	neutral	3.82	23.40	deleterious	0.2	0.45	NA	NA	0.49	neutral	0.65	disease	0.63	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-0.57	medium_impact	1.7	medium_impact	0.46	0.8	46.84	9.23	0.59	P	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8477	8477	T	C	MI.1682	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	112	38	S	P	Tca/Cca	-4.5	0	0	benign	0.06	neutral	0.25	neutral	1.57	neutral	-0.71	neutral	-1.84	low_impact	1.28	1	neutral	0.69	neutral	0.60	8.13	deleterious	0.56663707	0.85	0.5	disease	0.34	neutral	0.2	neutral	0.21	neutral	6	0.73	neutral	0.6	deleterious	-6	neutral	0.21	neutral	0.38	medium_impact	0.02	medium_impact	0	medium_impact	0.42	0.85	20.59	7.81	0.52	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	10995	10995	C	A	MI.16820	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	236	79	A	E	gCa/gAa	7.21	1	0	probably_damaging	1	deleterious	0	neutral	0.17	deleterious	-7.3	deleterious	-3.86	high_impact	3.55	0.73	neutral	0.43	neutral	4.29	24.00	deleterious	0.04	0.35	NA	NA	0.7	disease	0.78	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.39	high_impact	0.15	0.8	46.84	9.23	0.56	P	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10995	10995	C	T	MI.16821	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	236	79	A	V	gCa/gTa	7.21	1	0	probably_damaging	1	neutral	0.07	neutral	0.18	deleterious	-6.58	deleterious	-3.09	high_impact	3.55	0.59	damaging	0.51	neutral	4.37	24.10	deleterious	0.14	0.4	NA	NA	0.59	disease	0.67	disease	0.68	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.78	deleterious	-3.54	low_impact	-0.43	medium_impact	2.39	high_impact	0.49	0.8	46.84	9.23	0.62	P	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10997	10997	A	T	MI.16822	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	238	80	S	C	Agc/Tgc	-12.85	0	0	probably_damaging	0.99	deleterious	0	neutral	0.05	deleterious	-7.93	deleterious	-3.78	medium_impact	3.49	0.62	neutral	0.13	damaging	3.38	23.00	deleterious	0.06	0.35	NA	NA	0.58	disease	0.72	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-2.59	low_impact	-1.48	low_impact	2.33	high_impact	0.39	0.8	16.56	16.09	0.33	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10997	10997	A	C	MI.16823	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	238	80	S	R	Agc/Cgc	-12.85	0	0	probably_damaging	0.97	deleterious	0	neutral	0.06	deleterious	-6.93	deleterious	-3.78	medium_impact	3.49	0.66	neutral	0.13	damaging	3.75	23.30	deleterious	0.04	0.35	NA	NA	0.71	disease	0.81	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-2.14	low_impact	-1.48	low_impact	2.33	high_impact	0.40	0.8	16.56	16.09	0.39	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10997	10997	A	G	MI.16824	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	238	80	S	G	Agc/Ggc	-12.85	0	0	possibly_damaging	0.89	neutral	0.06	neutral	0.08	deleterious	-6.11	deleterious	-3.06	medium_impact	3.49	0.66	neutral	0.24	damaging	3.49	23.10	deleterious	0.17	0.45	NA	NA	0.44	neutral	0.74	disease	0.59	disease	2	0.98	neutral	0.09	neutral	0	NA	0.74	deleterious	-1.57	low_impact	-0.47	medium_impact	2.33	high_impact	0.64	0.8	16.56	16.09	0.38	N	0.87	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10998	10998	G	C	MI.16825	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	239	80	S	T	aGc/aCc	6.75	1	0	benign	0.26	neutral	0.09	neutral	0.1	deleterious	-5.47	neutral	-2.13	medium_impact	2.59	0.56	damaging	0.2	damaging	3.23	22.80	deleterious	0.19	0.45	NA	NA	0.45	neutral	0.68	disease	0.43	neutral	2	0.89	neutral	0.42	neutral	-3	neutral	0.75	deleterious	-0.29	medium_impact	-0.36	medium_impact	1.44	medium_impact	0.64	0.8	16.56	16.09	0.65	P	0.73	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10998	10998	G	A	MI.16826	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	239	80	S	N	aGc/aAc	6.75	1	0	probably_damaging	0.91	deleterious	0	neutral	0.08	deleterious	-6	neutral	-2.26	medium_impact	3.15	0.62	neutral	0.16	damaging	3.56	23.10	deleterious	0.27	0.45	NA	NA	0.55	disease	0.7	disease	0.66	disease	3	1	deleterious	0.05	neutral	5	deleterious	0.77	deleterious	-1.66	low_impact	-1.48	low_impact	1.99	medium_impact	0.45	0.8	16.56	16.09	0.59	P	0.91	polymorphism	1	0.05	.	.	.	.	.	.	COSM1155501	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	10998	10998	G	T	MI.16827	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	239	80	S	I	aGc/aTc	6.75	1	0	probably_damaging	0.94	deleterious	0.02	neutral	0.06	deleterious	-7.42	deleterious	-4.53	medium_impact	3.49	0.62	neutral	0.18	damaging	3.99	23.60	deleterious	0.04	0.35	NA	NA	0.79	disease	0.75	disease	0.76	disease	5	1	deleterious	0.04	neutral	5	deleterious	0.80	deleterious	-1.84	low_impact	-0.75	medium_impact	2.33	high_impact	0.29	0.8	16.56	16.09	0.53	P	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11000	11000	C	A	MI.16828	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	241	81	Q	K	Caa/Aaa	-1.09	0.01	0	probably_damaging	1	neutral	0.23	neutral	1.34	neutral	-1.9	deleterious	-3.08	medium_impact	3.11	0.63	neutral	0.16	damaging	3.78	23.40	deleterious	0.27	0.45	NA	NA	0.55	disease	0.71	disease	0.67	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.09	medium_impact	1.95	medium_impact	0.25	0.8	46.84	9.35	0.36	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11000	11000	C	G	MI.16829	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	241	81	Q	E	Caa/Gaa	-1.09	0.01	0	probably_damaging	1	neutral	0.34	neutral	1.37	neutral	-1.48	neutral	-2.31	medium_impact	2.56	0.64	neutral	0.17	damaging	2.93	22.00	deleterious	0.36	0.5	NA	NA	0.36	neutral	0.72	disease	0.41	neutral	2	1	deleterious	0.17	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.04	medium_impact	1.41	medium_impact	0.30	0.8	46.84	9.35	0.32	N	0.93	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8478	8478	C	G	MI.1683	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	113	38	S	W	tCa/tGa	-1.72	0	0	benign	0.43	neutral	0.21	neutral	1.55	neutral	-1.44	deleterious	-3.96	medium_impact	3.08	1	neutral	0.44	neutral	2.63	20.40	deleterious	0.43790363	0.85	0.81	disease	0.32	neutral	0.55	disease	0.23	neutral	6	0.76	neutral	0.39	neutral	-3	neutral	0.43	neutral	-0.64	medium_impact	-0.03	medium_impact	1.54	medium_impact	0.48	0.85	20.59	7.81	0.5	N	0.60	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11001	11001	A	G	MI.16830	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	242	81	Q	R	cAa/cGa	7.21	1	0	probably_damaging	1	neutral	0.18	neutral	1.3	neutral	-2.55	deleterious	-3.08	medium_impact	3.11	0.6	damaging	0.17	damaging	3.36	22.90	deleterious	0.25	0.45	NA	NA	0.58	disease	0.74	disease	0.72	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.17	medium_impact	1.95	medium_impact	0.09	0.8	46.84	9.35	0.64	P	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11001	11001	A	T	MI.16831	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	242	81	Q	L	cAa/cTa	7.21	1	0	probably_damaging	1	neutral	0.33	neutral	1.3	neutral	-2.46	deleterious	-5.4	medium_impact	3.46	0.68	neutral	0.16	damaging	3.73	23.30	deleterious	0.1	0.4	NA	NA	0.64	disease	0.68	disease	0.68	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.03	medium_impact	2.3	high_impact	0.06	0.8	46.84	9.35	0.64	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11001	11001	A	C	MI.16832	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	242	81	Q	P	cAa/cCa	7.21	1	0	probably_damaging	1	neutral	0.14	neutral	1.26	deleterious	-4.06	deleterious	-4.63	medium_impact	3.46	0.6	damaging	0.15	damaging	3.20	22.70	deleterious	0.06	0.35	NA	NA	0.69	disease	0.8	disease	0.76	disease	5	1	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.24	medium_impact	2.3	high_impact	0.26	0.8	46.84	9.35	0.65	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11002	11002	A	T	MI.16833	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	243	81	Q	H	caA/caT	8.59	1	0.02	probably_damaging	1	neutral	0.27	neutral	1.27	deleterious	-3.34	deleterious	-3.86	medium_impact	3.11	0.73	neutral	0.15	damaging	3.47	23.00	deleterious	0.3	0.45	NA	NA	0.55	disease	0.73	disease	0.71	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.04	medium_impact	1.95	medium_impact	0.54	0.8	46.84	9.35	0.66	P	0.97	polymorphism	1	0.08	rs386829114	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11002	11002	A	C	MI.16834	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	243	81	Q	H	caA/caC	8.59	1	0.02	probably_damaging	1	neutral	0.27	neutral	1.27	deleterious	-3.34	deleterious	-3.86	medium_impact	3.11	0.73	neutral	0.15	damaging	3.35	22.90	deleterious	0.3	0.45	NA	NA	0.55	disease	0.73	disease	0.71	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.04	medium_impact	1.95	medium_impact	0.54	0.8	46.84	9.35	0.66	P	0.97	polymorphism	1	0.08	rs386829114	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11003	11003	C	G	MI.16835	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	244	82	R	G	Cgc/Ggc	0.75	0.02	0	benign	0.15	neutral	0.26	neutral	1.58	neutral	-0.02	neutral	-0.61	neutral_impact	0	0.74	neutral	0.64	neutral	2.16	17.24	deleterious	0.13	0.4	NA	NA	0.23	neutral	0.52	disease	0.28	neutral	4	0.7	neutral	0.56	deleterious	-6	neutral	0.18	neutral	-0.01	medium_impact	-0.05	medium_impact	-1.13	low_impact	0.24	0.8	28.98	18.21	0.44	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11003	11003	C	A	MI.16836	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	244	82	R	S	Cgc/Agc	0.75	0.02	0	benign	0.11	neutral	0.42	neutral	1.7	neutral	1.42	neutral	0.41	neutral_impact	-0.9	0.74	neutral	0.95	neutral	1.55	13.57	neutral	0.12	0.4	NA	NA	0.15	neutral	0.35	neutral	0.23	neutral	5	0.51	neutral	0.66	deleterious	-6	neutral	0.17	neutral	0.14	medium_impact	0.12	medium_impact	-2.02	low_impact	0.17	0.8	28.98	18.21	0.4	N	0.30	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11003	11003	C	T	MI.16837	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	244	82	R	C	Cgc/Tgc	0.75	0.02	0	possibly_damaging	0.76	deleterious	0.01	neutral	1.52	deleterious	-3.51	neutral	-1.82	neutral_impact	0.34	0.68	neutral	0.31	neutral	4.62	24.50	deleterious	0.13	0.4	NA	NA	0.37	neutral	0.5	neutral	0.15	neutral	7	0.99	deleterious	0.13	neutral	1	deleterious	0.62	deleterious	-1.19	low_impact	-0.92	medium_impact	-0.79	medium_impact	0.80	0.85	28.98	18.21	0.36	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11004	11004	G	A	MI.16838	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	245	82	R	H	cGc/cAc	-0.4	0	0	benign	0	neutral	0.09	neutral	1.57	neutral	-0.29	neutral	1.78	neutral_impact	-2.14	0.74	neutral	0.94	neutral	1.05	10.94	neutral	0.36	0.5	NA	NA	0.12	neutral	0.2	neutral	0.27	neutral	5	0.91	neutral	0.55	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	-0.36	medium_impact	-3.24	low_impact	0.84	0.9	28.98	18.21	0.5	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11004	11004	G	C	MI.16839	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	245	82	R	P	cGc/cCc	-0.4	0	0	benign	0.36	neutral	0.09	neutral	1.53	neutral	-1.59	neutral	-1.22	neutral_impact	0	0.68	neutral	0.29	neutral	2.32	18.32	deleterious	0.03	0.35	NA	NA	0.61	disease	0.7	disease	0.72	disease	4	0.89	neutral	0.37	neutral	-6	neutral	0.38	neutral	-0.48	medium_impact	-0.36	medium_impact	-1.13	low_impact	0.13	0.8	28.98	18.21	0.3	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8478	8478	C	T	MI.1684	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	113	38	S	L	tCa/tTa	-1.72	0	0	benign	0	neutral	0.61	neutral	1.71	neutral	1.83	deleterious	-2.71	low_impact	1.28	1	neutral	0.82	neutral	1.15	11.49	neutral	0.71043795	0.85	0.37	neutral	0.19	neutral	0.29	neutral	0.08	neutral	8	0.39	neutral	0.81	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.4	medium_impact	0	medium_impact	0.87	0.90	20.59	7.81	0.29	N	0.20	polymorphism	1	0.06	rs201902227	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11004	11004	G	T	MI.16840	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	245	82	R	L	cGc/cTc	-0.4	0	0	benign	0.07	deleterious	0.04	neutral	1.55	neutral	-0.92	neutral	-1.65	neutral_impact	0.34	0.82	neutral	0.48	neutral	2.29	18.13	deleterious	0.13	0.4	NA	NA	0.35	neutral	0.53	disease	0.32	neutral	4	0.96	neutral	0.49	deleterious	-2	neutral	0.20	neutral	0.34	medium_impact	-0.57	medium_impact	-0.79	medium_impact	0.01	0.8	28.98	18.21	0.4	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11006	11006	C	T	MI.16841	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	247	83	H	Y	Cac/Tac	-3.17	0	0	probably_damaging	1	neutral	1	neutral	1.39	neutral	2.31	deleterious	-4.64	medium_impact	3.07	0.67	neutral	0.12	damaging	3.62	23.20	deleterious	0.34	0.5	NA	NA	0.58	disease	0.74	disease	0.7	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.78	deleterious	-3.54	low_impact	1.88	high_impact	1.91	medium_impact	0.14	0.8	47.49	9.4	0.3	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11006	11006	C	A	MI.16842	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	247	83	H	N	Cac/Aac	-3.17	0	0	probably_damaging	1	neutral	0.31	neutral	1.38	neutral	-0.7	deleterious	-5.41	medium_impact	3.42	0.69	neutral	0.16	damaging	3.75	23.30	deleterious	0.35	0.5	NA	NA	0.55	disease	0.73	disease	0.7	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.01	medium_impact	2.26	high_impact	0.23	0.8	47.49	9.4	0.34	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11006	11006	C	G	MI.16843	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	247	83	H	D	Cac/Gac	-3.17	0	0	probably_damaging	1	neutral	0.2	neutral	1.37	neutral	-0.51	deleterious	-6.96	medium_impact	3.42	0.64	neutral	0.13	damaging	3.71	23.30	deleterious	0.06	0.35	NA	NA	0.68	disease	0.77	disease	0.74	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.14	medium_impact	2.26	high_impact	0.26	0.8	47.49	9.4	0.38	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11007	11007	A	T	MI.16844	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	248	83	H	L	cAc/cTc	5.6	1	0	probably_damaging	1	neutral	0.67	neutral	1.51	neutral	-0.86	deleterious	-8.51	medium_impact	3.42	0.7	neutral	0.12	damaging	3.72	23.30	deleterious	0.08	0.35	NA	NA	0.65	disease	0.72	disease	0.68	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.37	medium_impact	2.26	high_impact	0.12	0.8	47.49	9.4	0.55	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11007	11007	A	G	MI.16845	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	248	83	H	R	cAc/cGc	5.6	1	0	probably_damaging	1	neutral	0.37	neutral	1.39	neutral	-0.9	deleterious	-6.19	medium_impact	2.87	0.63	neutral	0.14	damaging	2.87	21.70	deleterious	0.19	0.45	NA	NA	0.58	disease	0.67	disease	0.67	disease	3	1	deleterious	0.19	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.07	medium_impact	1.71	medium_impact	0.22	0.8	47.49	9.4	0.6	P	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11007	11007	A	C	MI.16846	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	248	83	H	P	cAc/cCc	5.6	1	0	probably_damaging	1	neutral	0.2	neutral	1.37	neutral	-1.79	deleterious	-7.73	medium_impact	3.42	0.72	neutral	0.13	damaging	3.09	22.50	deleterious	0.05	0.35	NA	NA	0.75	disease	0.82	disease	0.8	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.14	medium_impact	2.26	high_impact	0.12	0.8	47.49	9.4	0.64	P	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11008	11008	C	G	MI.16847	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	249	83	H	Q	caC/caG	6.75	1	0	probably_damaging	1	neutral	0.29	neutral	1.39	neutral	-0.66	deleterious	-6.19	medium_impact	3.42	0.68	neutral	0.13	damaging	3.48	23.10	deleterious	0.24	0.45	NA	NA	0.58	disease	0.73	disease	0.72	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.02	medium_impact	2.26	high_impact	0.26	0.8	47.49	9.4	0.65	P	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11008	11008	C	A	MI.16848	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	249	83	H	Q	caC/caA	6.75	1	0	probably_damaging	1	neutral	0.29	neutral	1.39	neutral	-0.66	deleterious	-6.19	medium_impact	3.42	0.68	neutral	0.13	damaging	3.76	23.30	deleterious	0.24	0.45	NA	NA	0.58	disease	0.73	disease	0.72	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.02	medium_impact	2.26	high_impact	0.26	0.8	47.49	9.4	0.65	P	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11009	11009	T	A	MI.16849	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	250	84	L	M	Tta/Ata	-0.63	0	0	possibly_damaging	0.68	neutral	0.25	neutral	1.39	neutral	0.15	neutral	-0.73	low_impact	1.09	0.76	neutral	0.95	neutral	2.07	16.68	deleterious	0.29	0.45	NA	NA	0.09	neutral	0.19	neutral	0.25	neutral	5	0.79	neutral	0.29	neutral	-3	neutral	0.70	deleterious	-1.03	low_impact	-0.07	medium_impact	-0.05	medium_impact	0.50	0.8	14.81	15.64	0.52	P	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8480	8480	C	T	MI.1685	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	115	39	P	S	Cca/Tca	-1.95	0	0	probably_damaging	1	neutral	0.49	neutral	1.68	neutral	1.55	deleterious	-2.54	low_impact	0.89	1	neutral	0.93	neutral	2.50	19.49	deleterious	0.48647755	0.85	0.18	neutral	0.14	neutral	0.19	neutral	0.13	neutral	7	0.99	deleterious	0.25	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.28	medium_impact	-0.34	medium_impact	0.33	0.85	7.35	7.21	0.5	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11009	11009	T	G	MI.16850	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	250	84	L	V	Tta/Gta	-0.63	0	0	possibly_damaging	0.86	neutral	0.44	neutral	1.38	neutral	-0.93	neutral	-1.47	medium_impact	2.35	0.75	neutral	0.69	neutral	2.20	17.50	deleterious	0.28	0.45	NA	NA	0.26	neutral	0.48	neutral	0.2	neutral	6	0.85	neutral	0.29	neutral	0	NA	0.72	deleterious	-1.46	low_impact	0.14	medium_impact	1.2	medium_impact	0.31	0.8	14.81	15.64	0.45	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11010	11010	T	C	MI.16851	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	251	84	L	S	tTa/tCa	-1.32	0	0	probably_damaging	0.98	neutral	0.05	neutral	1.3	neutral	-2.83	deleterious	-3.68	medium_impact	2.55	0.74	neutral	0.52	neutral	3.65	23.20	deleterious	0.09	0.35	NA	NA	0.52	disease	0.61	disease	0.69	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-2.31	low_impact	-0.52	medium_impact	1.4	medium_impact	0.23	0.8	14.81	15.64	0.4	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11010	11010	T	G	MI.16852	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	251	84	L	W	tTa/tGa	-1.32	0	0	probably_damaging	0.99	deleterious	0.02	neutral	1.25	deleterious	-4.39	deleterious	-3.93	medium_impact	2.9	0.78	neutral	0.42	neutral	3.68	23.30	deleterious	0.11	0.4	NA	NA	0.54	disease	0.65	disease	0.7	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-2.59	low_impact	-0.75	medium_impact	1.74	medium_impact	0.22	0.8	14.81	15.64	0.37	N	0.89	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11011	11011	A	T	MI.16853	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	252	84	L	F	ttA/ttT	4.21	0.48	0	probably_damaging	0.96	neutral	0.23	neutral	1.33	neutral	-2.42	deleterious	-2.5	medium_impact	2.9	0.73	neutral	0.47	neutral	3.49	23.10	deleterious	0.27	0.45	NA	NA	0.33	neutral	0.61	disease	0.38	neutral	3	0.97	neutral	0.14	neutral	1	deleterious	0.73	deleterious	-2.01	low_impact	-0.09	medium_impact	1.74	medium_impact	0.31	0.8	14.81	15.64	0.48	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11011	11011	A	C	MI.16854	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	252	84	L	F	ttA/ttC	4.21	0.48	0	probably_damaging	0.96	neutral	0.23	neutral	1.33	neutral	-2.42	deleterious	-2.5	medium_impact	2.9	0.73	neutral	0.47	neutral	3.40	23.00	deleterious	0.27	0.45	NA	NA	0.33	neutral	0.61	disease	0.38	neutral	3	0.97	neutral	0.14	neutral	1	deleterious	0.73	deleterious	-2.01	low_impact	-0.09	medium_impact	1.74	medium_impact	0.31	0.8	14.81	15.64	0.47	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11012	11012	T	G	MI.16855	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	253	85	S	A	Tcc/Gcc	-3.63	0	0	benign	0.12	neutral	0.61	neutral	1.52	neutral	-0.45	neutral	-0.99	low_impact	1.24	0.72	neutral	0.98	neutral	-0.26	0.83	neutral	0.56	0.6	NA	NA	0.09	neutral	0.29	neutral	0.21	neutral	6	0.29	neutral	0.75	deleterious	-6	neutral	0.18	neutral	0.1	medium_impact	0.31	medium_impact	0.1	medium_impact	0.35	0.8	35.08	30.78	0.4	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11012	11012	T	C	MI.16856	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	253	85	S	P	Tcc/Ccc	-3.63	0	0	possibly_damaging	0.71	neutral	0.2	neutral	1.44	neutral	-2.44	neutral	-1.86	medium_impact	2.17	0.7	neutral	0.42	neutral	2.44	19.09	deleterious	0.22	0.45	NA	NA	0.65	disease	0.49	neutral	0.5	neutral	0	0.84	neutral	0.25	neutral	0	NA	0.67	deleterious	-1.08	low_impact	-0.14	medium_impact	1.02	medium_impact	0.17	0.8	35.08	30.78	0.38	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11012	11012	T	A	MI.16857	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	253	85	S	T	Tcc/Acc	-3.63	0	0	benign	0.3	neutral	0.45	neutral	1.51	neutral	-1.53	neutral	-0.84	low_impact	1.83	0.72	neutral	0.98	neutral	0.08	3.39	deleterious	0.59	0.65	NA	NA	0.12	neutral	0.19	neutral	0.25	neutral	5	0.46	neutral	0.58	deleterious	-6	neutral	0.31	neutral	-0.37	medium_impact	0.15	medium_impact	0.68	medium_impact	0.38	0.8	35.08	30.78	0.56	P	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11013	11013	C	A	MI.16858	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	254	85	S	Y	tCc/tAc	-5.24	0	0.01	benign	0.01	neutral	0.44	neutral	1.44	deleterious	-3.17	neutral	-2.03	low_impact	1.83	0.8	neutral	0.76	neutral	0.26	5.26	deleterious	0.24	0.45	NA	NA	0.4	neutral	0.41	neutral	0.15	neutral	7	0.55	neutral	0.72	deleterious	-6	neutral	0.11	neutral	1.16	medium_impact	0.14	medium_impact	0.68	medium_impact	0.15	0.8	35.08	30.78	0.33	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11013	11013	C	T	MI.16859	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	254	85	S	F	tCc/tTc	-5.24	0	0.01	benign	0.18	neutral	0.34	neutral	1.44	deleterious	-3.1	neutral	-2.39	medium_impact	2.52	0.75	neutral	0.56	neutral	0.74	9.08	deleterious	0.27	0.45	NA	NA	0.37	neutral	0.41	neutral	0.15	neutral	7	0.6	neutral	0.58	deleterious	-3	neutral	0.29	neutral	-0.1	medium_impact	0.04	medium_impact	1.37	medium_impact	0.07	0.8	35.08	30.78	0.43	N	0.73	polymorphism	1	0.07	rs879244441	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8480	8480	C	A	MI.1686	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	115	39	P	T	Cca/Aca	-1.95	0	0	probably_damaging	1	neutral	0.46	neutral	1.61	neutral	0.53	deleterious	-2.62	low_impact	1.46	0.97	neutral	0.94	neutral	1.67	14.25	neutral	0.57564883	0.85	0.26	neutral	0.1	neutral	0.2	neutral	0.05	neutral	9	0.99	deleterious	0.23	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.25	medium_impact	0.15	medium_impact	0.66	0.85	7.35	7.21	0.41	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11013	11013	C	G	MI.16860	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	254	85	S	C	tCc/tGc	-5.24	0	0.01	benign	0.02	neutral	0.1	neutral	1.42	deleterious	-4.99	neutral	-2.29	low_impact	1.43	0.78	neutral	0.72	neutral	2.19	17.46	deleterious	0.26	0.45	NA	NA	0.38	neutral	0.47	neutral	0.16	neutral	7	0.9	neutral	0.54	deleterious	-6	neutral	0.64	deleterious	0.87	medium_impact	-0.33	medium_impact	0.29	medium_impact	0.16	0.8	35.08	30.78	0.43	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11015	11015	A	C	MI.16861	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	256	86	S	R	Agt/Cgt	-8.24	0	0	benign	0.06	neutral	0.38	neutral	1.48	neutral	-0.77	neutral	-0.01	low_impact	1.7	0.76	neutral	0.54	neutral	0.53	7.64	deleterious	0.31	0.45	NA	NA	0.45	neutral	0.35	neutral	0.21	neutral	6	0.58	neutral	0.66	deleterious	-6	neutral	0.15	neutral	0.41	medium_impact	0.08	medium_impact	0.56	medium_impact	0.33	0.8	26.14	26.33	0.39	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11015	11015	A	T	MI.16862	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	256	86	S	C	Agt/Tgt	-8.24	0	0	possibly_damaging	0.71	neutral	0.18	neutral	1.42	deleterious	-4.1	neutral	-2.31	low_impact	1.7	0.79	neutral	0.42	neutral	2.87	21.70	deleterious	0.33	0.5	NA	NA	0.38	neutral	0.29	neutral	0.16	neutral	7	0.86	neutral	0.24	neutral	-3	neutral	0.51	deleterious	-1.08	low_impact	-0.17	medium_impact	0.56	medium_impact	0.20	0.8	26.14	26.33	0.36	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11015	11015	A	G	MI.16863	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	256	86	S	G	Agt/Ggt	-8.24	0	0	benign	0.04	neutral	0.36	neutral	1.45	neutral	-0.53	neutral	-1.5	low_impact	1.35	0.79	neutral	0.66	neutral	0.29	5.58	deleterious	0.44	0.55	NA	NA	0.22	neutral	0.26	neutral	0.16	neutral	7	0.61	neutral	0.66	deleterious	-6	neutral	0.09	neutral	0.58	medium_impact	0.06	medium_impact	0.21	medium_impact	0.38	0.8	26.14	26.33	0.43	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11016	11016	G	T	MI.16864	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	257	86	S	I	aGt/aTt	-0.4	0	0.06	benign	0.34	neutral	0.41	neutral	1.44	neutral	-2.38	neutral	-2.27	low_impact	1.35	0.8	neutral	0.67	neutral	1.06	11.00	neutral	0.26	0.45	NA	NA	0.44	neutral	0.3	neutral	0.22	neutral	6	0.51	neutral	0.54	deleterious	-6	neutral	0.20	neutral	-0.45	medium_impact	0.11	medium_impact	0.21	medium_impact	0.32	0.8	26.14	26.33	0.31	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11016	11016	G	A	MI.16865	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	257	86	S	N	aGt/aAt	-0.4	0	0.06	benign	0	neutral	0.35	neutral	1.57	neutral	-1.06	neutral	0.21	neutral_impact	-0.14	0.76	neutral	0.99	neutral	-0.63	0.11	neutral	0.65	0.7	NA	NA	0.16	neutral	0.16	neutral	0.21	neutral	6	0.65	neutral	0.68	deleterious	-6	neutral	0.08	neutral	2.1	high_impact	0.05	medium_impact	-1.26	low_impact	0.39	0.8	26.14	26.33	0.53	N	0.01	polymorphism	1	0.00	rs28594904	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11016	11016	G	C	MI.16866	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	257	86	S	T	aGt/aCt	-0.4	0	0.06	benign	0.06	neutral	0.43	neutral	1.52	neutral	-0.99	neutral	-0.71	neutral_impact	0.46	0.76	neutral	0.81	neutral	-0.21	1.02	neutral	0.58	0.65	NA	NA	0.1	neutral	0.13	neutral	0.22	neutral	6	0.52	neutral	0.69	deleterious	-6	neutral	0.08	neutral	0.41	medium_impact	0.13	medium_impact	-0.67	medium_impact	0.49	0.8	26.14	26.33	0.49	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11018	11018	G	C	MI.16867	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	259	87	E	Q	Gaa/Caa	-2.94	0	0	benign	0.34	neutral	0.16	neutral	1.34	neutral	-1.95	neutral	-2	medium_impact	2.72	0.69	neutral	0.19	damaging	3.25	22.80	deleterious	0.74	0.8	NA	NA	0.6	disease	0.44	neutral	0.46	neutral	1	0.81	neutral	0.41	neutral	-3	neutral	0.79	deleterious	-0.45	medium_impact	-0.2	medium_impact	1.57	medium_impact	0.49	0.8	19.61	16.52	0.33	N	0.81	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11018	11018	G	A	MI.16868	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	259	87	E	K	Gaa/Aaa	-2.94	0	0	possibly_damaging	0.81	neutral	0.3	neutral	1.37	neutral	-1.13	deleterious	-2.69	medium_impact	2.37	0.71	neutral	0.15	damaging	4.36	24.10	deleterious	0.27	0.45	NA	NA	0.7	disease	0.55	disease	0.52	disease	0	0.85	neutral	0.25	neutral	0	NA	0.82	deleterious	-1.31	low_impact	0	medium_impact	1.22	medium_impact	0.42	0.8	19.61	16.52	0.39	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11019	11019	A	G	MI.16869	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	260	87	E	G	gAa/gGa	6.06	1	0	possibly_damaging	0.88	neutral	0.11	neutral	1.28	neutral	-2.62	deleterious	-4.59	medium_impact	2.92	0.77	neutral	0.57	neutral	4.17	23.80	deleterious	0.5	0.6	NA	NA	0.65	disease	0.67	disease	0.68	disease	4	0.96	neutral	0.12	neutral	0	NA	0.80	deleterious	-1.53	low_impact	-0.31	medium_impact	1.76	medium_impact	0.15	0.8	19.61	16.52	0.65	P	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8480	8480	C	G	MI.1687	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	115	39	P	A	Cca/Gca	-1.95	0	0	probably_damaging	0.99	neutral	0.59	neutral	1.62	neutral	0.71	deleterious	-3	medium_impact	2.15	0.99	neutral	0.83	neutral	1.61	13.91	neutral	0.46889253	0.85	0.26	neutral	0.08	neutral	0.34	neutral	0.05	neutral	9	0.99	deleterious	0.3	neutral	1	deleterious	0.69	deleterious	-2.65	low_impact	0.38	medium_impact	0.75	medium_impact	0.74	0.85	7.35	7.21	0.43	N	0.40	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11019	11019	A	C	MI.16870	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	260	87	E	A	gAa/gCa	6.06	1	0	possibly_damaging	0.81	neutral	0.19	neutral	1.33	neutral	-1.86	deleterious	-4.12	medium_impact	3.27	0.71	neutral	0.19	damaging	3.59	23.20	deleterious	0.53	0.6	NA	NA	0.53	disease	0.66	disease	0.59	disease	2	0.89	neutral	0.19	neutral	0	NA	0.79	deleterious	-1.31	low_impact	-0.15	medium_impact	2.11	high_impact	0.27	0.8	19.61	16.52	0.68	P	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11019	11019	A	T	MI.16871	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	260	87	E	V	gAa/gTa	6.06	1	0	probably_damaging	0.96	neutral	0.09	neutral	1.28	deleterious	-3.39	deleterious	-4.87	medium_impact	3.27	0.65	neutral	0.15	damaging	4.12	23.80	deleterious	0.27	0.45	NA	NA	0.74	disease	0.67	disease	0.65	disease	3	0.99	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-2.01	low_impact	-0.36	medium_impact	2.11	high_impact	0.35	0.8	19.61	16.52	0.62	P	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11020	11020	A	C	MI.16872	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	261	87	E	D	gaA/gaC	5.6	1	0	possibly_damaging	0.73	neutral	0.21	neutral	1.33	neutral	-0.36	neutral	-1.72	medium_impact	2.58	0.76	neutral	0.59	neutral	3.51	23.10	deleterious	0.62	0.65	NA	NA	0.58	disease	0.38	neutral	0.44	neutral	1	0.84	neutral	0.24	neutral	0	NA	0.78	deleterious	-1.12	low_impact	-0.12	medium_impact	1.43	medium_impact	0.52	0.8	19.61	16.52	0.67	P	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11020	11020	A	T	MI.16873	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	261	87	E	D	gaA/gaT	5.6	1	0	possibly_damaging	0.73	neutral	0.21	neutral	1.33	neutral	-0.36	neutral	-1.72	medium_impact	2.58	0.76	neutral	0.59	neutral	3.62	23.20	deleterious	0.62	0.65	NA	NA	0.58	disease	0.38	neutral	0.44	neutral	1	0.84	neutral	0.24	neutral	0	NA	0.78	deleterious	-1.12	low_impact	-0.12	medium_impact	1.43	medium_impact	0.52	0.8	19.61	16.52	0.68	P	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11021	11021	C	T	MI.16874	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	262	88	P	S	Cca/Tca	-0.17	0	0	benign	0.02	neutral	0.35	neutral	1.41	neutral	-0.88	neutral	-1.61	low_impact	1.29	0.81	neutral	0.96	neutral	0.36	6.25	deleterious	0.42	0.55	NA	NA	0.37	neutral	0.36	neutral	0.16	neutral	7	0.64	neutral	0.67	deleterious	-6	neutral	0.15	neutral	0.87	medium_impact	0.05	medium_impact	0.15	medium_impact	0.20	0.8	8.93	15.25	0.38	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11021	11021	C	G	MI.16875	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	262	88	P	A	Cca/Gca	-0.17	0	0	benign	0.17	neutral	0.3	neutral	1.29	neutral	-1.96	deleterious	-2.61	medium_impact	2.69	0.69	neutral	0.58	neutral	1.10	11.22	neutral	0.65	0.7	NA	NA	0.31	neutral	0.58	disease	0.38	neutral	2	0.65	neutral	0.57	deleterious	-3	neutral	0.30	neutral	-0.07	medium_impact	0	medium_impact	1.54	medium_impact	0.38	0.8	8.93	15.25	0.43	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11021	11021	C	A	MI.16876	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	262	88	P	T	Cca/Aca	-0.17	0	0	benign	0.25	neutral	0.32	neutral	1.29	neutral	-1.9	neutral	-2.1	low_impact	1.47	0.8	neutral	0.96	neutral	0.75	9.15	deleterious	0.46	0.55	NA	NA	0.33	neutral	0.36	neutral	0.16	neutral	7	0.61	neutral	0.54	deleterious	-6	neutral	0.39	neutral	-0.27	medium_impact	0.02	medium_impact	0.33	medium_impact	0.38	0.8	8.93	15.25	0.38	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11022	11022	C	T	MI.16877	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	263	88	P	L	cCa/cTa	-0.86	0	0	possibly_damaging	0.57	neutral	0.51	neutral	1.21	deleterious	-3.47	deleterious	-4.19	medium_impact	2.49	0.7	neutral	0.46	neutral	3.76	23.30	deleterious	0.49	0.55	NA	NA	0.57	disease	0.56	disease	0.63	disease	3	0.55	neutral	0.47	deleterious	0	NA	0.52	deleterious	-0.83	medium_impact	0.21	medium_impact	1.34	medium_impact	0.70	0.85	8.93	15.25	0.31	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11022	11022	C	A	MI.16878	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	263	88	P	Q	cCa/cAa	-0.86	0	0	possibly_damaging	0.75	neutral	0.17	neutral	1.22	deleterious	-3.22	deleterious	-2.61	medium_impact	3.04	0.77	neutral	0.56	neutral	3.70	23.30	deleterious	0.38	0.5	NA	NA	0.61	disease	0.54	disease	0.61	disease	2	0.88	neutral	0.21	neutral	0	NA	0.62	deleterious	-1.17	low_impact	-0.18	medium_impact	1.88	medium_impact	0.24	0.8	8.93	15.25	0.39	N	0.58	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11022	11022	C	G	MI.16879	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	263	88	P	R	cCa/cGa	-0.86	0	0	possibly_damaging	0.57	neutral	0.2	neutral	1.22	deleterious	-3.34	deleterious	-3.26	medium_impact	3.04	0.63	neutral	0.39	neutral	3.10	22.50	deleterious	0.33	0.5	NA	NA	0.56	disease	0.65	disease	0.65	disease	3	0.8	neutral	0.32	neutral	0	NA	0.61	deleterious	-0.83	medium_impact	-0.14	medium_impact	1.88	medium_impact	0.36	0.8	8.93	15.25	0.37	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8481	8481	C	T	MI.1688	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	116	39	P	L	cCa/cTa	-2.65	0	0	probably_damaging	1	neutral	0.7	neutral	1.56	neutral	-0.73	deleterious	-3.92	low_impact	1.46	0.98	neutral	0.92	neutral	2.92	22.00	deleterious	0.43790363	0.85	0.28	neutral	0.18	neutral	0.33	neutral	0.13	neutral	8	1	deleterious	0.35	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.5	medium_impact	0.15	medium_impact	0.84	0.85	7.35	7.21	0.37	N	0.29	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	C8481T	Tetralogy of Fallot patient	+	-	Reported	1	.	P	P	neutral
chrM	11024	11024	C	A	MI.16880	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	265	89	L	M	Cta/Ata	-9.85	0	0	probably_damaging	0.94	neutral	0.26	neutral	1.5	neutral	-1.43	neutral	-0.4	medium_impact	2.44	0.77	neutral	0.91	neutral	1.97	16.02	deleterious	0.25	0.45	NA	NA	0.09	neutral	0.17	neutral	0.24	neutral	5	0.96	neutral	0.16	neutral	1	deleterious	0.53	deleterious	-1.84	low_impact	-0.05	medium_impact	1.29	medium_impact	0.36	0.8	29.63	19.55	0.55	P	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11024	11024	C	G	MI.16881	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	265	89	L	V	Cta/Gta	-9.85	0	0	possibly_damaging	0.68	neutral	0.53	neutral	1.51	neutral	-1.25	neutral	-0.53	low_impact	1.28	0.76	neutral	0.92	neutral	-0.13	1.55	neutral	0.25	0.45	NA	NA	0.13	neutral	0.29	neutral	0.25	neutral	5	0.65	neutral	0.43	neutral	-3	neutral	0.18	neutral	-1.03	low_impact	0.23	medium_impact	0.14	medium_impact	0.41	0.8	29.63	19.55	0.34	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11025	11025	T	A	MI.16882	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	266	89	L	Q	cTa/cAa	-5.47	0	0.01	probably_damaging	0.92	neutral	0.3	neutral	1.54	neutral	-0.71	neutral	-1.83	medium_impact	2.08	0.78	neutral	0.78	neutral	2.43	19.05	deleterious	0.21	0.45	NA	NA	0.32	neutral	0.23	neutral	0.19	neutral	6	0.93	neutral	0.19	neutral	1	deleterious	0.49	deleterious	-1.71	low_impact	0	medium_impact	0.93	medium_impact	0.20	0.8	29.63	19.55	0.42	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11025	11025	T	C	MI.16883	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	266	89	L	P	cTa/cCa	-5.47	0	0.01	benign	0.02	neutral	0.24	neutral	1.5	neutral	-1.56	neutral	-2.17	neutral_impact	0.48	0.8	neutral	0.99	neutral	0.31	5.77	deleterious	0.15	0.45	NA	NA	0.41	neutral	0.24	neutral	0.18	neutral	6	0.75	neutral	0.61	deleterious	-6	neutral	0.15	neutral	0.87	medium_impact	-0.08	medium_impact	-0.65	medium_impact	0.22	0.8	29.63	19.55	0.39	N	0.03	polymorphism	1	0.02	rs201300253	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11025	11025	T	G	MI.16884	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	266	89	L	R	cTa/cGa	-5.47	0	0.01	probably_damaging	0.92	neutral	0.34	neutral	1.53	neutral	-0.84	neutral	-2.18	medium_impact	2.44	0.7	neutral	0.58	neutral	2.32	18.29	deleterious	0.17	0.45	NA	NA	0.43	neutral	0.4	neutral	0.22	neutral	6	0.93	neutral	0.21	neutral	1	deleterious	0.52	deleterious	-1.71	low_impact	0.04	medium_impact	1.29	medium_impact	0.16	0.8	29.63	19.55	0.39	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11027	11027	T	C	MI.16885	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	268	90	S	P	Tca/Cca	-9.39	0	0	benign	0.02	neutral	0.23	neutral	1.53	neutral	-1.98	neutral	-1.61	neutral_impact	0.45	0.77	neutral	0.93	neutral	0.85	9.75	deleterious	0.28	0.45	NA	NA	0.57	disease	0.2	neutral	0.43	neutral	1	0.76	neutral	0.61	deleterious	-6	neutral	0.46	deleterious	0.87	medium_impact	-0.09	medium_impact	-0.68	medium_impact	0.23	0.8	29.41	24.09	0.42	N	0.68	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11027	11027	T	G	MI.16886	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	268	90	S	A	Tca/Gca	-9.39	0	0	benign	0.25	neutral	0.36	neutral	1.56	neutral	-0.52	neutral	-0.82	low_impact	0.96	0.76	neutral	0.98	neutral	0.05	3.07	deleterious	0.49	0.55	NA	NA	0.15	neutral	0.28	neutral	0.18	neutral	7	0.56	neutral	0.56	deleterious	-6	neutral	0.10	neutral	-0.27	medium_impact	0.06	medium_impact	-0.18	medium_impact	0.31	0.8	29.41	24.09	0.45	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11027	11027	T	A	MI.16887	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	268	90	S	T	Tca/Aca	-9.39	0	0	benign	0.03	neutral	0.45	neutral	1.57	neutral	-1.05	neutral	0.38	neutral_impact	-0.06	0.76	neutral	0.99	neutral	-0.47	0.26	neutral	0.52	0.6	NA	NA	0.08	neutral	0.17	neutral	0.19	neutral	6	0.52	neutral	0.71	deleterious	-6	neutral	0.10	neutral	0.7	medium_impact	0.15	medium_impact	-1.19	low_impact	0.46	0.8	29.41	24.09	0.48	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11028	11028	C	G	MI.16888	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	269	90	S	W	tCa/tGa	-5.7	0	0	probably_damaging	0.92	deleterious	0.03	neutral	1.48	deleterious	-4.25	neutral	-2.37	medium_impact	2	0.78	neutral	0.43	neutral	2.86	21.70	deleterious	0.17	0.45	NA	NA	0.61	disease	0.46	neutral	0.48	neutral	0	0.99	deleterious	0.06	neutral	5	deleterious	0.65	deleterious	-1.71	low_impact	-0.64	medium_impact	0.85	medium_impact	0.17	0.8	29.41	24.09	0.35	N	0.58	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11028	11028	C	T	MI.16889	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	269	90	S	L	tCa/tTa	-5.7	0	0	benign	0.02	neutral	0.19	neutral	1.56	neutral	-2.04	neutral	-1.24	neutral_impact	0.41	0.81	neutral	0.95	neutral	0.87	9.90	deleterious	0.34	0.5	NA	NA	0.35	neutral	0.3	neutral	0.18	neutral	6	0.8	neutral	0.59	deleterious	-6	neutral	0.10	neutral	0.87	medium_impact	-0.15	medium_impact	-0.72	medium_impact	0.59	0.8	29.41	24.09	0.42	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8481	8481	C	A	MI.1689	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	116	39	P	Q	cCa/cAa	-2.65	0	0	probably_damaging	1	neutral	0.36	neutral	1.59	neutral	0.24	deleterious	-2.64	low_impact	1.52	0.99	neutral	0.81	neutral	2.11	16.91	deleterious	0.42878708	0.85	0.42	neutral	0.13	neutral	0.25	neutral	0.07	neutral	9	1	deleterious	0.18	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.15	medium_impact	0.21	medium_impact	0.59	0.85	7.35	7.21	0.5	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11030	11030	C	T	MI.16890	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	271	91	R	W	Cga/Tga	-3.86	0	0	benign	0.11	neutral	0.13	neutral	1.39	deleterious	-6.89	deleterious	-5.05	medium_impact	2.74	0.7	neutral	0.3	neutral	5.09	25.30	deleterious	0.2	0.45	NA	NA	0.85	disease	0.67	disease	0.75	disease	5	0.85	neutral	0.51	deleterious	-3	neutral	0.85	deleterious	0.14	medium_impact	-0.26	medium_impact	1.59	medium_impact	0.87	0.9	24.84	23.34	0.32	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11030	11030	C	G	MI.16891	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	271	91	R	G	Cga/Gga	-3.86	0	0	possibly_damaging	0.78	neutral	0.24	neutral	1.42	deleterious	-3.33	deleterious	-4.42	medium_impact	3.08	0.72	neutral	0.41	neutral	4.12	23.80	deleterious	0.24	0.45	NA	NA	0.72	disease	0.71	disease	0.7	disease	4	0.85	neutral	0.23	neutral	0	NA	0.82	deleterious	-1.23	low_impact	-0.08	medium_impact	1.92	medium_impact	0.23	0.8	24.84	23.34	0.34	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11031	11031	G	T	MI.16892	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	272	91	R	L	cGa/cTa	1.21	0.02	0	possibly_damaging	0.64	neutral	0.54	neutral	1.43	deleterious	-3.1	deleterious	-4.53	medium_impact	2.19	0.78	neutral	0.55	neutral	4.16	23.80	deleterious	0.24	0.45	NA	NA	0.86	disease	0.68	disease	0.7	disease	4	0.61	neutral	0.45	neutral	0	NA	0.85	deleterious	-0.95	medium_impact	0.24	medium_impact	1.04	medium_impact	0.06	0.8	24.84	23.34	0.24	N	0.61	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11031	11031	G	A	MI.16893	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	272	91	R	Q	cGa/cAa	1.21	0.02	0	benign	0.09	neutral	0.22	neutral	1.48	neutral	-1.98	neutral	-2.15	low_impact	1.56	0.75	neutral	0.63	neutral	4.34	24.00	deleterious	0.26	0.45	NA	NA	0.69	disease	0.54	disease	0.49	neutral	0	0.75	neutral	0.57	deleterious	-6	neutral	0.80	deleterious	0.23	medium_impact	-0.11	medium_impact	0.42	medium_impact	0.77	0.85	24.84	23.34	0.41	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11031	11031	G	C	MI.16894	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	272	91	R	P	cGa/cCa	1.21	0.02	0	probably_damaging	0.95	neutral	0.12	neutral	1.4	deleterious	-4.07	deleterious	-4.44	medium_impact	3.08	0.65	neutral	0.28	damaging	4.13	23.80	deleterious	0.13	0.4	NA	NA	0.86	disease	0.71	disease	0.78	disease	6	0.98	neutral	0.09	neutral	1	deleterious	0.88	deleterious	-1.92	low_impact	-0.28	medium_impact	1.92	medium_impact	0.19	0.8	24.84	23.34	0.36	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11033	11033	A	C	MI.16895	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	274	92	K	Q	Aaa/Caa	-0.4	0	0	probably_damaging	1	neutral	1	neutral	1.61	neutral	0.16	neutral	-1.08	low_impact	1.12	0.68	neutral	0.82	neutral	0.64	8.45	deleterious	0.35	0.5	NA	NA	0.13	neutral	0.24	neutral	0.21	neutral	6	1	deleterious	0.5	deleterious	-2	neutral	0.71	deleterious	-3.54	low_impact	1.88	high_impact	-0.02	medium_impact	0.34	0.8	14.6	18.78	0.32	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11033	11033	A	G	MI.16896	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	274	92	K	E	Aaa/Gaa	-0.4	0	0	probably_damaging	1	neutral	0.3	neutral	1.5	neutral	-0.71	neutral	-1.82	medium_impact	3.17	0.67	neutral	0.18	damaging	3.92	23.50	deleterious	0.25	0.45	NA	NA	0.7	disease	0.67	disease	0.58	disease	2	1	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0	medium_impact	2.01	high_impact	0.41	0.8	14.6	18.78	0.41	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11034	11034	A	T	MI.16897	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	275	92	K	M	aAa/aTa	2.14	0.93	0	probably_damaging	1	neutral	0.1	neutral	1.38	deleterious	-3.54	deleterious	-3.24	medium_impact	2.83	0.73	neutral	0.2	damaging	3.57	23.10	deleterious	0.19	0.45	NA	NA	0.57	disease	0.63	disease	0.64	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.33	medium_impact	1.67	medium_impact	0.19	0.8	14.6	18.78	0.4	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11034	11034	A	C	MI.16898	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	275	92	K	T	aAa/aCa	2.14	0.93	0	probably_damaging	1	neutral	0.23	neutral	1.44	neutral	-1.62	deleterious	-3.48	medium_impact	2.83	0.7	neutral	0.24	damaging	3.27	22.80	deleterious	0.25	0.45	NA	NA	0.5	neutral	0.56	disease	0.59	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.09	medium_impact	1.67	medium_impact	0.39	0.8	14.6	18.78	0.46	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11035	11035	A	T	MI.16899	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	276	92	K	N	aaA/aaT	8.59	1	0	probably_damaging	1	neutral	0.33	neutral	1.44	neutral	-1.51	deleterious	-2.79	medium_impact	3.17	0.68	neutral	0.19	damaging	3.61	23.20	deleterious	0.53	0.6	NA	NA	0.57	disease	0.64	disease	0.54	disease	1	1	deleterious	0.17	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.03	medium_impact	2.01	high_impact	0.38	0.8	14.6	18.78	0.66	P	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8605	8605	C	T	MI.169	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	79	27	P	S	Ccc/Tcc	-6.58	0	0	probably_damaging	1	neutral	0.45	neutral	4.42	neutral	0.41	deleterious	-7.11	medium_impact	2.41	0.67	neutral	0.62	neutral	3.67	23.20	deleterious	0.46	0.65	0.35	neutral	0.75	disease	0.45	neutral	0.54	disease	1	1	deleterious	0.23	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.24	medium_impact	0.97	medium_impact	0.26	0.9	48.23	8.81	0.32	N	0.84	polymorphism	0.75	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8481	8481	C	G	MI.1690	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	116	39	P	R	cCa/cGa	-2.65	0	0	probably_damaging	1	neutral	0.4	neutral	1.65	neutral	1.18	deleterious	-3.75	medium_impact	3.13	1	neutral	0.37	neutral	2.13	17.07	deleterious	0.40896277	0.85	0.43	neutral	0.22	neutral	0.43	neutral	0.13	neutral	7	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.19	medium_impact	1.59	medium_impact	0.68	0.85	7.35	7.21	0.48	N	0.58	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11035	11035	A	C	MI.16900	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	276	92	K	N	aaA/aaC	8.59	1	0	probably_damaging	1	neutral	0.33	neutral	1.44	neutral	-1.51	deleterious	-2.79	medium_impact	3.17	0.68	neutral	0.19	damaging	3.53	23.10	deleterious	0.53	0.6	NA	NA	0.57	disease	0.64	disease	0.54	disease	1	1	deleterious	0.17	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.03	medium_impact	2.01	high_impact	0.38	0.8	14.6	18.78	0.66	P	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11036	11036	A	C	MI.16901	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	277	93	K	Q	Aaa/Caa	2.6	1	0	probably_damaging	1	neutral	0.08	neutral	1.5	neutral	-0.84	neutral	-2.29	medium_impact	2.52	0.61	neutral	0.38	neutral	3.00	22.20	deleterious	0.27	0.45	NA	NA	0.4	neutral	0.35	neutral	0.15	neutral	7	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.39	medium_impact	1.37	medium_impact	0.34	0.8	46.84	8.88	0.62	P	0.86	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11036	11036	A	G	MI.16902	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	277	93	K	E	Aaa/Gaa	2.6	1	0	probably_damaging	1	neutral	0.05	neutral	1.52	neutral	-0.66	deleterious	-2.56	medium_impact	2.73	0.48	damaging	0.14	damaging	3.58	23.20	deleterious	0.18	0.45	NA	NA	0.68	disease	0.64	disease	0.72	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.52	medium_impact	1.58	medium_impact	0.36	0.8	46.84	8.88	0.62	P	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11037	11037	A	C	MI.16903	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	278	93	K	T	aAa/aCa	3.75	1	0	probably_damaging	1	neutral	0.14	neutral	1.48	neutral	-1.2	deleterious	-3.85	medium_impact	3.08	0.49	damaging	0.14	damaging	3.41	23.00	deleterious	0.15	0.45	NA	NA	0.37	neutral	0.62	disease	0.37	neutral	3	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.24	medium_impact	1.92	medium_impact	0.20	0.8	46.84	8.88	0.67	P	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11037	11037	A	T	MI.16904	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	278	93	K	M	aAa/aTa	3.75	1	0	probably_damaging	1	neutral	0.07	neutral	1.42	deleterious	-3.12	deleterious	-3.85	medium_impact	3.08	0.48	damaging	0.13	damaging	3.63	23.20	deleterious	0.13	0.4	NA	NA	0.52	disease	0.61	disease	0.7	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.43	medium_impact	1.92	medium_impact	0.21	0.8	46.84	8.88	0.62	P	0.42	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11038	11038	A	T	MI.16905	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	279	93	K	N	aaA/aaT	3.29	1	0	probably_damaging	1	neutral	0.31	neutral	1.51	neutral	-0.79	deleterious	-3.08	medium_impact	2.27	0.52	damaging	0.13	damaging	3.72	23.30	deleterious	0.5	0.6	NA	NA	0.45	neutral	0.53	disease	0.34	neutral	3	1	deleterious	0.16	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.01	medium_impact	1.12	medium_impact	0.30	0.8	46.84	8.88	0.58	P	0.72	polymorphism	1	0.07	rs386829117	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11038	11038	A	C	MI.16906	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	279	93	K	N	aaA/aaC	3.29	1	0	probably_damaging	1	neutral	0.31	neutral	1.51	neutral	-0.79	deleterious	-3.08	medium_impact	2.27	0.52	damaging	0.13	damaging	3.67	23.30	deleterious	0.5	0.6	NA	NA	0.45	neutral	0.53	disease	0.34	neutral	3	1	deleterious	0.16	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.01	medium_impact	1.12	medium_impact	0.30	0.8	46.84	8.88	0.58	P	0.72	polymorphism	1	0.07	rs386829117	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11039	11039	C	G	MI.16907	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	280	94	L	V	Ctc/Gtc	0.06	0	0	possibly_damaging	0.52	neutral	0.39	neutral	1.48	neutral	-0.87	neutral	-0.79	medium_impact	2.12	0.74	neutral	0.82	neutral	2.06	16.63	deleterious	0.45	0.55	NA	NA	0.17	neutral	0.24	neutral	0.22	neutral	6	0.6	neutral	0.44	neutral	0	NA	0.70	deleterious	-0.75	medium_impact	0.09	medium_impact	0.97	medium_impact	0.37	0.8	26.36	16.11	0.5	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11039	11039	C	A	MI.16908	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	280	94	L	I	Ctc/Atc	0.06	0	0	benign	0.12	neutral	0.48	neutral	1.48	neutral	-0.79	neutral	-0.56	low_impact	1.48	0.68	neutral	0.85	neutral	2.77	21.20	deleterious	0.39	0.5	NA	NA	0.11	neutral	0.2	neutral	0.23	neutral	5	0.44	neutral	0.68	deleterious	-6	neutral	0.69	deleterious	0.1	medium_impact	0.18	medium_impact	0.34	medium_impact	0.48	0.8	26.36	16.11	0.49	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11039	11039	C	T	MI.16909	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	280	94	L	F	Ctc/Ttc	0.06	0	0	benign	0.17	neutral	0.77	neutral	1.42	neutral	-1.57	neutral	-1.52	medium_impact	2.37	0.79	neutral	0.69	neutral	2.70	20.80	deleterious	0.28	0.45	NA	NA	0.2	neutral	0.24	neutral	0.19	neutral	6	0.12	neutral	0.8	deleterious	-3	neutral	0.70	deleterious	-0.07	medium_impact	0.5	medium_impact	1.22	medium_impact	0.48	0.8	26.36	16.11	0.3	N	0.99	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8483	8483	A	C	MI.1691	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	118	40	K	Q	Aag/Cag	-2.65	0	0	benign	0.37	neutral	0.66	neutral	1.81	neutral	-2.26	deleterious	-3.02	medium_impact	2.6	0.98	neutral	0.52	neutral	1.68	14.28	neutral	0.81027320	0.90	0.39	neutral	0.48	neutral	0.4	neutral	0.35	neutral	3	0.3	neutral	0.65	deleterious	-3	neutral	0.32	neutral	-0.54	medium_impact	0.45	medium_impact	1.13	medium_impact	0.51	0.85	NA	NA	0.32	N	0.59	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11040	11040	T	A	MI.16910	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	281	94	L	H	cTc/cAc	-0.4	0	0	probably_damaging	0.98	neutral	0.35	neutral	1.36	deleterious	-3.56	deleterious	-2.97	medium_impact	2.92	0.77	neutral	0.74	neutral	3.13	22.60	deleterious	0.08	0.35	NA	NA	0.42	neutral	0.52	disease	0.35	neutral	3	0.99	deleterious	0.19	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	0.05	medium_impact	1.76	medium_impact	0.15	0.8	26.36	16.11	0.39	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11040	11040	T	G	MI.16911	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	281	94	L	R	cTc/cGc	-0.4	0	0	probably_damaging	0.96	neutral	0.24	neutral	1.37	deleterious	-3.12	deleterious	-2.62	medium_impact	2.92	0.7	neutral	0.43	neutral	4.05	23.70	deleterious	0.07	0.35	NA	NA	0.58	disease	0.59	disease	0.7	disease	4	0.97	neutral	0.14	neutral	1	deleterious	0.79	deleterious	-2.01	low_impact	-0.08	medium_impact	1.76	medium_impact	0.11	0.8	26.36	16.11	0.38	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11040	11040	T	C	MI.16912	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	281	94	L	P	cTc/cCc	-0.4	0	0	probably_damaging	0.97	neutral	0.12	neutral	1.36	deleterious	-3.62	deleterious	-3.1	medium_impact	2.92	0.62	neutral	0.37	neutral	3.83	23.40	deleterious	0.02	0.35	NA	NA	0.69	disease	0.63	disease	0.72	disease	4	0.99	deleterious	0.08	neutral	1	deleterious	0.82	deleterious	-2.14	low_impact	-0.28	medium_impact	1.76	medium_impact	0.06	0.8	26.36	16.11	0.35	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	COSM6716724	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11042	11042	T	G	MI.16913	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	283	95	Y	D	Tac/Gac	-11.24	0	0	probably_damaging	0.98	deleterious	0	neutral	1.24	deleterious	-6.49	deleterious	-7.21	medium_impact	3.34	0.71	neutral	0.38	neutral	3.79	23.40	deleterious	0.02	0.35	NA	NA	0.86	disease	0.76	disease	0.8	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.86	deleterious	-2.31	low_impact	-1.48	low_impact	2.18	high_impact	0.12	0.8	45.75	11.64	0.39	N	0.93	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11042	11042	T	A	MI.16914	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	283	95	Y	N	Tac/Aac	-11.24	0	0	probably_damaging	0.98	deleterious	0.04	neutral	1.24	deleterious	-5.33	deleterious	-6.57	medium_impact	3.34	0.72	neutral	0.54	neutral	3.87	23.50	deleterious	0.03	0.35	NA	NA	0.78	disease	0.67	disease	0.71	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.82	deleterious	-2.31	low_impact	-0.57	medium_impact	2.18	high_impact	0.22	0.8	45.75	11.64	0.42	N	0.89	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11042	11042	T	C	MI.16915	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	283	95	Y	H	Tac/Cac	-11.24	0	0	probably_damaging	0.98	deleterious	0	neutral	1.26	deleterious	-4.1	deleterious	-3.73	medium_impact	3.34	0.73	neutral	0.41	neutral	3.42	23.00	deleterious	0.08	0.35	NA	NA	0.72	disease	0.75	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-2.31	low_impact	-1.48	low_impact	2.18	high_impact	0.22	0.8	45.75	11.64	0.38	N	0.84	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11043	11043	A	T	MI.16916	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	284	95	Y	F	tAc/tTc	2.83	0.23	0	benign	0.17	neutral	1	neutral	2.58	neutral	2.49	neutral	-2.23	low_impact	1.49	0.79	neutral	0.98	neutral	2.60	20.20	deleterious	0.16	0.45	NA	NA	0.14	neutral	0.32	neutral	0.18	neutral	6	0.17	neutral	0.92	deleterious	-6	neutral	0.74	deleterious	-0.07	medium_impact	1.88	high_impact	0.35	medium_impact	0.51	0.8	45.75	11.64	0.36	N	0.18	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11043	11043	A	G	MI.16917	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	284	95	Y	C	tAc/tGc	2.83	0.23	0	probably_damaging	0.99	neutral	0.05	neutral	1.24	deleterious	-6.5	deleterious	-6.41	medium_impact	3	0.75	neutral	0.39	neutral	3.93	23.50	deleterious	0.03	0.35	NA	NA	0.79	disease	0.7	disease	0.72	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.82	deleterious	-2.59	low_impact	-0.52	medium_impact	1.84	medium_impact	0.15	0.8	45.75	11.64	0.41	N	0.94	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11043	11043	A	C	MI.16918	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	284	95	Y	S	tAc/tCc	2.83	0.23	0	probably_damaging	0.98	neutral	0.05	neutral	1.25	deleterious	-5.05	deleterious	-6.44	medium_impact	3.34	0.72	neutral	0.54	neutral	4.06	23.70	deleterious	0.03	0.35	NA	NA	0.77	disease	0.67	disease	0.7	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.83	deleterious	-2.31	low_impact	-0.52	medium_impact	2.18	high_impact	0.23	0.8	45.75	11.64	0.43	N	0.90	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11045	11045	C	A	MI.16919	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	286	96	L	I	Ctc/Atc	-4.55	0	0	benign	0.08	neutral	1	neutral	1.57	neutral	-1.26	neutral	1.02	neutral_impact	-0.6	0.71	neutral	0.97	neutral	1.37	12.62	neutral	0.29	0.45	NA	NA	0.04	neutral	0.14	neutral	0.2	neutral	6	0.08	neutral	0.96	deleterious	-6	neutral	0.69	deleterious	0.28	medium_impact	1.88	high_impact	-1.72	low_impact	0.50	0.8	25.27	24.78	0.41	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8483	8483	A	G	MI.1692	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	118	40	K	E	Aag/Gag	-2.65	0	0	benign	0.17	neutral	0.47	neutral	1.84	neutral	-1.53	deleterious	-2.81	medium_impact	2.65	1	neutral	0.85	neutral	2.17	17.28	deleterious	0.53197893	0.85	0.35	neutral	0.42	neutral	0.47	neutral	0.21	neutral	6	0.44	neutral	0.65	deleterious	-3	neutral	0.34	neutral	-0.1	medium_impact	0.26	medium_impact	1.17	medium_impact	0.50	0.85	NA	NA	0.45	N	0.35	polymorphism	1	0.14	rs377093295	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11045	11045	C	G	MI.16920	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	286	96	L	V	Ctc/Gtc	-4.55	0	0	benign	0.05	neutral	0.15	neutral	1.39	neutral	-1.14	neutral	0.28	low_impact	1.32	0.76	neutral	0.89	neutral	3.24	22.80	deleterious	0.27	0.45	NA	NA	0.41	neutral	0.43	neutral	0.19	neutral	6	0.84	neutral	0.55	deleterious	-6	neutral	0.74	deleterious	0.48	medium_impact	-0.22	medium_impact	0.18	medium_impact	0.67	0.85	25.27	24.78	0.45	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11045	11045	C	T	MI.16921	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	286	96	L	F	Ctc/Ttc	-4.55	0	0	possibly_damaging	0.88	deleterious	0.03	neutral	1.3	neutral	-0.16	neutral	-1.78	medium_impact	2.48	0.65	neutral	0.72	neutral	3.80	23.40	deleterious	0.26	0.45	NA	NA	0.51	disease	0.44	neutral	0.48	neutral	0	0.99	deleterious	0.08	neutral	4	deleterious	0.76	deleterious	-1.53	low_impact	-0.64	medium_impact	1.33	medium_impact	0.51	0.8	25.27	24.78	0.46	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11046	11046	T	A	MI.16922	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	287	96	L	H	cTc/cAc	0.75	0.37	0	probably_damaging	0.98	deleterious	0.01	neutral	1.26	neutral	-2.92	deleterious	-4.07	medium_impact	2.48	0.66	neutral	0.59	neutral	4.00	23.60	deleterious	0.05	0.35	NA	NA	0.65	disease	0.66	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-2.31	low_impact	-0.92	medium_impact	1.33	medium_impact	0.20	0.8	25.27	24.78	0.33	N	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11046	11046	T	C	MI.16923	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	287	96	L	P	cTc/cCc	0.75	0.37	0	probably_damaging	0.96	deleterious	0.01	neutral	1.26	deleterious	-3.39	deleterious	-4.07	medium_impact	2.48	0.58	damaging	0.45	neutral	3.77	23.40	deleterious	0.02	0.35	NA	NA	0.85	disease	0.71	disease	0.8	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.87	deleterious	-2.01	low_impact	-0.92	medium_impact	1.33	medium_impact	0.38	0.8	25.27	24.78	0.31	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11046	11046	T	G	MI.16924	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	287	96	L	R	cTc/cGc	0.75	0.37	0	probably_damaging	0.93	deleterious	0.01	neutral	1.27	deleterious	-4.11	deleterious	-3.94	medium_impact	2.48	0.65	neutral	0.52	neutral	4.10	23.70	deleterious	0.02	0.35	NA	NA	0.82	disease	0.7	disease	0.79	disease	6	1	deleterious	0.04	neutral	5	deleterious	0.86	deleterious	-1.77	low_impact	-0.92	medium_impact	1.33	medium_impact	0.11	0.8	25.27	24.78	0.32	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11048	11048	T	A	MI.16925	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	289	97	S	T	Tct/Act	-8.7	0	0	benign	0.03	neutral	0.68	neutral	1.62	neutral	0.41	neutral	0.18	neutral_impact	0	0.74	neutral	0.99	neutral	-0.96	0.02	neutral	0.25	0.45	NA	NA	0.06	neutral	0.17	neutral	0.19	neutral	6	0.27	neutral	0.83	deleterious	-6	neutral	0.11	neutral	0.7	medium_impact	0.39	medium_impact	-1.13	low_impact	0.67	0.85	18.74	14.9	0.48	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11048	11048	T	G	MI.16926	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	289	97	S	A	Tct/Gct	-8.7	0	0	benign	0.4	neutral	0.44	neutral	1.58	neutral	-0.12	neutral	-1.4	low_impact	1.66	0.77	neutral	0.86	neutral	0.69	8.75	deleterious	0.26	0.45	NA	NA	0.19	neutral	0.23	neutral	0.21	neutral	6	0.5	neutral	0.52	deleterious	-6	neutral	0.18	neutral	-0.55	medium_impact	0.14	medium_impact	0.52	medium_impact	0.60	0.8	18.74	14.9	0.4	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11048	11048	T	C	MI.16927	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	289	97	S	P	Tct/Cct	-8.7	0	0	possibly_damaging	0.89	neutral	0.13	neutral	1.48	neutral	-2.86	deleterious	-2.61	medium_impact	2.7	0.55	damaging	0.35	neutral	3.44	23.00	deleterious	0.05	0.35	NA	NA	0.78	disease	0.54	disease	0.75	disease	5	0.95	neutral	0.12	neutral	0	NA	0.54	deleterious	-1.57	low_impact	-0.26	medium_impact	1.55	medium_impact	0.33	0.8	18.74	14.9	0.39	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11049	11049	C	A	MI.16928	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	290	97	S	Y	tCt/tAt	-2.71	0	0	possibly_damaging	0.81	neutral	0.64	neutral	1.52	neutral	-1.15	deleterious	-3.15	medium_impact	2.7	0.8	neutral	0.51	neutral	3.72	23.30	deleterious	0.04	0.35	NA	NA	0.56	disease	0.45	neutral	0.51	disease	0	0.77	neutral	0.42	neutral	0	NA	0.63	deleterious	-1.31	low_impact	0.34	medium_impact	1.55	medium_impact	0.30	0.8	18.74	14.9	0.23	N	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11049	11049	C	T	MI.16929	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	290	97	S	F	tCt/tTt	-2.71	0	0	benign	0.07	neutral	1	neutral	1.65	neutral	0.63	deleterious	-3.07	low_impact	1.46	0.78	neutral	0.78	neutral	3.85	23.40	deleterious	0.06	0.35	NA	NA	0.46	neutral	0.32	neutral	0.23	neutral	5	0.07	neutral	0.97	deleterious	-6	neutral	0.62	deleterious	0.34	medium_impact	1.88	high_impact	0.32	medium_impact	0.29	0.8	18.74	14.9	0.21	N	0.11	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8484	8484	A	T	MI.1693	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	119	40	K	M	aAg/aTg	1.52	0	0	benign	0.04	neutral	0.28	neutral	1.78	deleterious	-3.59	deleterious	-4.28	medium_impact	2.86	0.99	neutral	0.78	neutral	1.91	15.63	deleterious	0.32447288	0.85	0.64	disease	0.36	neutral	0.43	neutral	0.27	neutral	5	0.7	neutral	0.62	deleterious	-3	neutral	0.24	neutral	0.55	medium_impact	0.06	medium_impact	1.35	medium_impact	0.38	0.85	NA	NA	0.53	N	0.33	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11049	11049	C	G	MI.16930	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	290	97	S	C	tCt/tGt	-2.71	0	0	probably_damaging	0.94	neutral	0.13	neutral	1.48	neutral	-2.69	neutral	-2.47	medium_impact	2.7	0.72	neutral	0.54	neutral	3.33	22.90	deleterious	0.06	0.35	NA	NA	0.49	neutral	0.31	neutral	0.47	neutral	1	0.97	neutral	0.1	neutral	1	deleterious	0.66	deleterious	-1.84	low_impact	-0.26	medium_impact	1.55	medium_impact	0.37	0.8	18.74	14.9	0.45	N	0.64	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11051	11051	A	C	MI.16931	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	292	98	M	L	Ata/Cta	-10.55	0	0	benign	0.33	neutral	1	neutral	1.74	neutral	2.5	neutral	-0.57	low_impact	1.16	0.68	neutral	0.95	neutral	0.43	6.88	deleterious	0.17	0.45	NA	NA	0.22	neutral	0.29	neutral	0.16	neutral	7	0.33	neutral	0.84	deleterious	-6	neutral	0.52	deleterious	-0.43	medium_impact	1.88	high_impact	0.02	medium_impact	0.34	0.8	15.9	13.46	0.38	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11051	11051	A	T	MI.16932	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	292	98	M	L	Ata/Tta	-10.55	0	0	benign	0.33	neutral	1	neutral	1.74	neutral	2.5	neutral	-0.57	low_impact	1.16	0.68	neutral	0.95	neutral	0.57	7.94	deleterious	0.17	0.45	NA	NA	0.22	neutral	0.29	neutral	0.16	neutral	7	0.33	neutral	0.84	deleterious	-6	neutral	0.52	deleterious	-0.43	medium_impact	1.88	high_impact	0.02	medium_impact	0.34	0.8	15.9	13.46	0.39	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11051	11051	A	G	MI.16933	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	292	98	M	V	Ata/Gta	-10.55	0	0	possibly_damaging	0.44	neutral	0.16	neutral	1.67	neutral	-0.06	neutral	-1.87	medium_impact	2.52	0.79	neutral	0.76	neutral	2.64	20.40	deleterious	0.14	0.4	NA	NA	0.42	neutral	0.48	neutral	0.18	neutral	6	0.82	neutral	0.36	neutral	0	NA	0.62	deleterious	-0.62	medium_impact	-0.2	medium_impact	1.37	medium_impact	0.39	0.8	15.9	13.46	0.44	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11052	11052	T	A	MI.16934	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	293	98	M	K	aTa/aAa	0.98	0	0	possibly_damaging	0.64	deleterious	0.03	neutral	1.49	neutral	-2.81	deleterious	-3.7	medium_impact	3.08	0.68	neutral	0.45	neutral	3.77	23.40	deleterious	0.02	0.35	NA	NA	0.69	disease	0.68	disease	0.73	disease	5	0.97	neutral	0.2	neutral	4	deleterious	0.78	deleterious	-0.95	medium_impact	-0.64	medium_impact	1.92	medium_impact	0.23	0.8	15.9	13.46	0.39	N	0.90	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11052	11052	T	C	MI.16935	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	293	98	M	T	aTa/aCa	0.98	0	0	benign	0.06	neutral	0.27	neutral	1.64	neutral	-1.14	deleterious	-3.1	low_impact	1.88	0.69	neutral	0.95	neutral	1.49	13.24	neutral	0.09	0.35	NA	NA	0.2	neutral	0.33	neutral	0.17	neutral	7	0.7	neutral	0.61	deleterious	-6	neutral	0.67	deleterious	0.41	medium_impact	-0.04	medium_impact	0.73	medium_impact	0.10	0.8	15.9	13.46	0.5	P	0.38	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11053	11053	A	T	MI.16936	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	294	98	M	I	atA/atT	1.91	0.02	0	possibly_damaging	0.44	neutral	0.22	neutral	1.59	neutral	-0.09	neutral	-1.6	medium_impact	2.27	0.75	neutral	0.75	neutral	3.30	22.90	deleterious	0.18	0.45	NA	NA	0.42	neutral	0.31	neutral	0.16	neutral	7	0.75	neutral	0.39	neutral	0	NA	0.67	deleterious	-0.62	medium_impact	-0.11	medium_impact	1.12	medium_impact	0.34	0.8	15.9	13.46	0.48	N	0.52	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11053	11053	A	C	MI.16937	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	294	98	M	I	atA/atC	1.91	0.02	0	possibly_damaging	0.44	neutral	0.22	neutral	1.59	neutral	-0.09	neutral	-1.6	medium_impact	2.27	0.75	neutral	0.75	neutral	3.26	22.80	deleterious	0.18	0.45	NA	NA	0.42	neutral	0.31	neutral	0.16	neutral	7	0.75	neutral	0.39	neutral	0	NA	0.67	deleterious	-0.62	medium_impact	-0.11	medium_impact	1.12	medium_impact	0.34	0.8	15.9	13.46	0.48	N	0.52	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11054	11054	C	A	MI.16938	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	295	99	L	M	Cta/Ata	-3.63	0	0	benign	0.22	neutral	0.13	neutral	1.3	neutral	-2.8	neutral	-1.22	low_impact	1.28	0.77	neutral	0.81	neutral	2.37	18.60	deleterious	0.21	0.45	NA	NA	0.38	neutral	0.25	neutral	0.2	neutral	6	0.85	neutral	0.46	neutral	-6	neutral	0.75	deleterious	-0.2	medium_impact	-0.26	medium_impact	0.14	medium_impact	0.36	0.8	20.7	24.68	0.41	N	0.08	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11054	11054	C	G	MI.16939	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	295	99	L	V	Cta/Gta	-3.63	0	0	possibly_damaging	0.64	neutral	0.33	neutral	1.46	neutral	-2.23	neutral	-2.12	medium_impact	2.67	0.69	neutral	0.57	neutral	3.28	22.80	deleterious	0.17	0.45	NA	NA	0.45	neutral	0.31	neutral	0.23	neutral	5	0.72	neutral	0.35	neutral	0	NA	0.77	deleterious	-0.95	medium_impact	0.03	medium_impact	1.52	medium_impact	0.44	0.8	20.7	24.68	0.42	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8484	8484	A	C	MI.1694	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	119	40	K	T	aAg/aCg	1.52	0	0	benign	0.2	neutral	0.59	neutral	1.92	neutral	-0.57	deleterious	-4.25	medium_impact	2.19	0.99	neutral	0.87	neutral	0.52	7.61	deleterious	0.45672233	0.85	0.26	neutral	0.49	neutral	0.39	neutral	0.38	neutral	2	0.3	neutral	0.7	deleterious	-3	neutral	0.29	neutral	-0.18	medium_impact	0.38	medium_impact	0.78	medium_impact	0.40	0.85	NA	NA	0.4	N	0.34	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11055	11055	T	A	MI.16940	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	296	99	L	Q	cTa/cAa	-1.09	0	0	probably_damaging	0.96	deleterious	0.04	neutral	1.28	deleterious	-5.33	deleterious	-4.33	medium_impact	3.23	0.67	neutral	0.4	neutral	4.07	23.70	deleterious	0.04	0.35	NA	NA	0.72	disease	0.39	neutral	0.52	disease	0	0.99	deleterious	0.04	neutral	5	deleterious	0.81	deleterious	-2.01	low_impact	-0.57	medium_impact	2.07	high_impact	0.27	0.8	20.7	24.68	0.44	N	0.86	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11055	11055	T	G	MI.16941	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	296	99	L	R	cTa/cGa	-1.09	0	0	probably_damaging	0.96	deleterious	0.01	neutral	1.26	deleterious	-5.23	deleterious	-4.38	medium_impact	3.23	0.57	damaging	0.36	neutral	4.05	23.70	deleterious	0.02	0.35	NA	NA	0.85	disease	0.71	disease	0.78	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.89	deleterious	-2.01	low_impact	-0.92	medium_impact	2.07	high_impact	0.12	0.8	20.7	24.68	0.33	N	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11055	11055	T	C	MI.16942	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	296	99	L	P	cTa/cCa	-1.09	0	0	probably_damaging	0.98	deleterious	0.01	neutral	1.25	deleterious	-5.77	deleterious	-5.15	medium_impact	3.23	0.55	damaging	0.39	neutral	3.84	23.40	deleterious	0.02	0.35	NA	NA	0.84	disease	0.72	disease	0.78	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.89	deleterious	-2.31	low_impact	-0.92	medium_impact	2.07	high_impact	0.33	0.8	20.7	24.68	0.33	N	0.96	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11057	11057	A	G	MI.16943	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	298	100	I	V	Atc/Gtc	-4.09	0	0	benign	0.08	neutral	0.41	neutral	1.54	neutral	0.25	neutral	-0.3	neutral_impact	0.5	0.8	neutral	0.99	neutral	1.47	13.13	neutral	0.34	0.5	NA	NA	0.21	neutral	0.2	neutral	0.21	neutral	6	0.54	neutral	0.67	deleterious	-6	neutral	0.63	deleterious	0.28	medium_impact	0.11	medium_impact	-0.63	medium_impact	0.31	0.8	47.49	9.25	0.45	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11057	11057	A	T	MI.16944	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	298	100	I	F	Atc/Ttc	-4.09	0	0	probably_damaging	0.96	neutral	0.31	neutral	1.39	neutral	-0.21	deleterious	-2.71	medium_impact	2.25	0.75	neutral	0.48	neutral	3.64	23.20	deleterious	0.16	0.45	NA	NA	0.63	disease	0.26	neutral	0.48	neutral	0	0.96	neutral	0.18	neutral	1	deleterious	0.76	deleterious	-2.01	low_impact	0.01	medium_impact	1.1	medium_impact	0.38	0.8	47.49	9.25	0.42	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11057	11057	A	C	MI.16945	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	298	100	I	L	Atc/Ctc	-4.09	0	0	possibly_damaging	0.52	neutral	1	neutral	1.57	neutral	2.11	neutral	-1.29	medium_impact	2.8	0.8	neutral	0.68	neutral	3.62	23.20	deleterious	0.21	0.45	NA	NA	0.49	neutral	0.27	neutral	0.4	neutral	2	0.51	neutral	0.74	deleterious	0	NA	0.68	deleterious	-0.75	medium_impact	1.88	high_impact	1.64	medium_impact	0.41	0.8	47.49	9.25	0.33	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11058	11058	T	G	MI.16946	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	299	100	I	S	aTc/aGc	-0.4	0	0	probably_damaging	0.94	neutral	0.28	neutral	1.39	neutral	-0.4	deleterious	-3.52	medium_impact	2.25	0.8	neutral	0.76	neutral	4.11	23.70	deleterious	0.05	0.35	NA	NA	0.71	disease	0.31	neutral	0.53	disease	1	0.95	neutral	0.17	neutral	1	deleterious	0.77	deleterious	-1.84	low_impact	-0.03	medium_impact	1.1	medium_impact	0.16	0.8	47.49	9.25	0.36	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11058	11058	T	A	MI.16947	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	299	100	I	N	aTc/aAc	-0.4	0	0	probably_damaging	0.98	neutral	0.12	neutral	1.35	neutral	-1.75	deleterious	-4.39	medium_impact	2.8	0.73	neutral	0.45	neutral	4.49	24.30	deleterious	0.09	0.35	NA	NA	0.74	disease	0.5	neutral	0.56	disease	1	0.99	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-2.31	low_impact	-0.28	medium_impact	1.64	medium_impact	0.15	0.8	47.49	9.25	0.39	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11058	11058	T	C	MI.16948	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	299	100	I	T	aTc/aCc	-0.4	0	0	possibly_damaging	0.83	neutral	0.34	neutral	1.45	neutral	-0.66	deleterious	-2.51	low_impact	1.06	0.73	neutral	0.98	neutral	1.83	15.17	deleterious	0.12	0.4	NA	NA	0.21	neutral	0.23	neutral	0.2	neutral	6	0.85	neutral	0.26	neutral	-3	neutral	0.69	deleterious	-1.37	low_impact	0.04	medium_impact	-0.08	medium_impact	0.25	0.8	47.49	9.25	0.42	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11059	11059	C	A	MI.16949	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	300	100	I	M	atC/atA	0.52	0	0.01	probably_damaging	0.96	neutral	0.17	neutral	1.4	neutral	-0.76	neutral	-1.83	medium_impact	2.8	0.79	neutral	0.6	neutral	3.68	23.30	deleterious	0.26	0.45	NA	NA	0.49	neutral	0.23	neutral	0.35	neutral	3	0.97	neutral	0.11	neutral	1	deleterious	0.73	deleterious	-2.01	low_impact	-0.18	medium_impact	1.64	medium_impact	0.53	0.8	47.49	9.25	0.42	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8485	8485	G	C	MI.1695	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	120	40	K	N	aaG/aaC	-3.8	0	0.01	possibly_damaging	0.44	neutral	0.58	neutral	1.92	neutral	-0.6	deleterious	-3.81	medium_impact	2.51	0.98	neutral	0.8	neutral	2.28	18.05	deleterious	0.78924240	0.85	0.45	neutral	0.43	neutral	0.42	neutral	0.23	neutral	5	0.41	neutral	0.57	deleterious	0	NA	0.39	neutral	-0.66	medium_impact	0.37	medium_impact	1.05	medium_impact	0.64	0.85	NA	NA	0.36	N	0.56	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11059	11059	C	G	MI.16950	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	300	100	I	M	atC/atG	0.52	0	0.01	probably_damaging	0.96	neutral	0.17	neutral	1.4	neutral	-0.76	neutral	-1.83	medium_impact	2.8	0.79	neutral	0.6	neutral	3.28	22.80	deleterious	0.26	0.45	NA	NA	0.49	neutral	0.23	neutral	0.35	neutral	3	0.97	neutral	0.11	neutral	1	deleterious	0.73	deleterious	-2.01	low_impact	-0.18	medium_impact	1.64	medium_impact	0.53	0.8	47.49	9.25	0.42	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11060	11060	T	G	MI.16951	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	301	101	S	A	Tcc/Gcc	-8.47	0	0	benign	0.05	neutral	0.38	neutral	1.59	neutral	0.08	neutral	-0.61	low_impact	1.92	0.77	neutral	0.81	neutral	-0.33	0.56	neutral	0.25	0.45	NA	NA	0.3	neutral	0.24	neutral	0.19	neutral	6	0.59	neutral	0.67	deleterious	-6	neutral	0.14	neutral	0.48	medium_impact	0.08	medium_impact	0.77	medium_impact	0.26	0.8	30.28	19.2	0.43	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11060	11060	T	C	MI.16952	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	301	101	S	P	Tcc/Ccc	-8.47	0	0	benign	0.41	neutral	0.11	neutral	1.49	neutral	-2.69	neutral	-2.15	medium_impact	2.48	0.61	neutral	0.4	neutral	0.64	8.42	deleterious	0.05	0.35	NA	NA	0.85	disease	0.63	disease	0.78	disease	6	0.87	neutral	0.35	neutral	-3	neutral	0.48	deleterious	-0.57	medium_impact	-0.31	medium_impact	1.33	medium_impact	0.26	0.8	30.28	19.2	0.34	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11060	11060	T	A	MI.16953	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	301	101	S	T	Tcc/Acc	-8.47	0	0	benign	0.01	neutral	0.4	neutral	1.58	neutral	-0.14	neutral	-0.44	low_impact	1.32	0.81	neutral	0.99	neutral	-0.38	0.42	neutral	0.26	0.45	NA	NA	0.2	neutral	0.19	neutral	0.21	neutral	6	0.59	neutral	0.7	deleterious	-6	neutral	0.10	neutral	1.16	medium_impact	0.1	medium_impact	0.18	medium_impact	0.42	0.8	30.28	19.2	0.5	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11061	11061	C	T	MI.16954	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	302	101	S	F	tCc/tTc	-5.93	0	0.01	benign	0	neutral	1	neutral	1.61	neutral	0.29	neutral	-1.23	neutral_impact	0.63	0.78	neutral	0.81	neutral	-0.05	2.14	deleterious	0.08	0.35	NA	NA	0.51	disease	0.29	neutral	0.42	neutral	2	0	neutral	1	deleterious	-6	neutral	0.31	neutral	2.1	high_impact	1.88	high_impact	-0.5	medium_impact	0.13	0.8	30.28	19.2	0.23	N	0.62	polymorphism	1	0.03	rs879204439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11061	11061	C	G	MI.16955	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	302	101	S	C	tCc/tGc	-5.93	0	0.01	benign	0.01	neutral	0.11	neutral	1.5	neutral	-1.97	neutral	-1.41	medium_impact	2.13	0.77	neutral	0.47	neutral	1.77	14.79	neutral	0.07	0.35	NA	NA	0.65	disease	0.49	neutral	0.49	neutral	0	0.89	neutral	0.55	deleterious	-3	neutral	0.57	deleterious	1.16	medium_impact	-0.31	medium_impact	0.98	medium_impact	0.22	0.8	30.28	19.2	0.35	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11061	11061	C	A	MI.16956	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	302	101	S	Y	tCc/tAc	-5.93	0	0.01	benign	0.17	neutral	0.56	neutral	1.52	neutral	-1.44	neutral	-1.64	medium_impact	2.13	0.81	neutral	0.62	neutral	-0.40	0.38	neutral	0.06	0.35	NA	NA	0.69	disease	0.45	neutral	0.5	neutral	0	0.33	neutral	0.7	deleterious	-3	neutral	0.54	deleterious	-0.07	medium_impact	0.26	medium_impact	0.98	medium_impact	0.20	0.8	30.28	19.2	0.21	N	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11063	11063	C	A	MI.16957	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	304	102	L	M	Cta/Ata	-11.01	0	0	probably_damaging	1	neutral	0.14	neutral	0.34	deleterious	-4.43	neutral	-1.55	medium_impact	3.19	0.49	damaging	0.1	damaging	3.64	23.20	deleterious	0.28	0.45	NA	NA	0.53	disease	0.57	disease	0.56	disease	1	1	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.24	medium_impact	2.03	high_impact	0.49	0.8	46.62	9.41	0.36	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11063	11063	C	G	MI.16958	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	304	102	L	V	Cta/Gta	-11.01	0	0	probably_damaging	1	neutral	0.06	neutral	0.34	deleterious	-4.36	neutral	-2.32	medium_impact	3.19	0.59	damaging	0.17	damaging	3.30	22.90	deleterious	0.25	0.45	NA	NA	0.51	disease	0.59	disease	0.46	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.47	medium_impact	2.03	high_impact	0.52	0.8	46.62	9.41	0.34	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11064	11064	T	A	MI.16959	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	305	102	L	Q	cTa/cAa	-0.86	0	0	probably_damaging	1	deleterious	0	neutral	0.25	deleterious	-7.85	deleterious	-4.64	high_impact	3.54	0.46	damaging	0.07	damaging	3.92	23.50	deleterious	0.05	0.35	NA	NA	0.76	disease	0.65	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.38	high_impact	0.24	0.8	46.62	9.41	0.36	N	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8485	8485	G	T	MI.1696	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	120	40	K	N	aaG/aaT	-3.8	0	0.01	possibly_damaging	0.44	neutral	0.58	neutral	1.92	neutral	-0.6	deleterious	-3.81	medium_impact	2.51	0.98	neutral	0.8	neutral	2.41	18.90	deleterious	0.78924240	0.85	0.45	neutral	0.43	neutral	0.42	neutral	0.23	neutral	5	0.41	neutral	0.57	deleterious	0	NA	0.39	neutral	-0.66	medium_impact	0.37	medium_impact	1.05	medium_impact	0.64	0.85	NA	NA	0.36	N	0.56	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11064	11064	T	C	MI.16960	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	305	102	L	P	cTa/cCa	-0.86	0	0	probably_damaging	1	deleterious	0	neutral	0.25	deleterious	-8.34	deleterious	-5.41	high_impact	3.54	0.41	damaging	0.07	damaging	3.76	23.30	deleterious	0.04	0.35	NA	NA	0.8	disease	0.75	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	2.38	high_impact	0.33	0.8	46.62	9.41	0.48	N	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11064	11064	T	G	MI.16961	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	305	102	L	R	cTa/cGa	-0.86	0	0	probably_damaging	1	deleterious	0	neutral	0.25	deleterious	-7.89	deleterious	-4.64	high_impact	3.54	0.44	damaging	0.06	damaging	4.06	23.70	deleterious	0.03	0.35	NA	NA	0.87	disease	0.76	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	2.38	high_impact	0.13	0.8	46.62	9.41	0.45	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11066	11066	C	A	MI.16962	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	307	103	Q	K	Caa/Aaa	-20	0	0	probably_damaging	1	neutral	0.29	neutral	1.4	neutral	-2.03	deleterious	-2.99	high_impact	3.51	0.71	neutral	0.15	damaging	3.81	23.40	deleterious	0.22	0.45	NA	NA	0.86	disease	0.74	disease	0.78	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.02	medium_impact	2.35	high_impact	0.35	0.8	46.84	9.32	0.37	N	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11066	11066	C	G	MI.16963	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	307	103	Q	E	Caa/Gaa	-20	0	0	probably_damaging	1	neutral	0.28	neutral	1.4	neutral	-1.99	neutral	-2.22	high_impact	3.51	0.69	neutral	0.17	damaging	2.96	22.10	deleterious	0.33	0.5	NA	NA	0.79	disease	0.72	disease	0.73	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	-0.03	medium_impact	2.35	high_impact	0.40	0.8	46.84	9.32	0.34	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11067	11067	A	G	MI.16964	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	308	103	Q	R	cAa/cGa	5.6	1	0	probably_damaging	1	neutral	0.35	neutral	1.38	neutral	-2.57	deleterious	-2.96	high_impact	3.51	0.68	neutral	0.15	damaging	3.07	22.40	deleterious	0.2	0.45	NA	NA	0.88	disease	0.75	disease	0.81	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.54	low_impact	0.05	medium_impact	2.35	high_impact	0.14	0.8	46.84	9.32	0.64	P	0.88	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11067	11067	A	C	MI.16965	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	308	103	Q	P	cAa/cCa	5.6	1	0	probably_damaging	1	neutral	0.2	neutral	1.36	deleterious	-3.68	deleterious	-4.51	high_impact	3.51	0.64	neutral	0.14	damaging	3.00	22.20	deleterious	0.06	0.35	NA	NA	0.9	disease	0.77	disease	0.82	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	-0.14	medium_impact	2.35	high_impact	0.35	0.8	46.84	9.32	0.63	P	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11067	11067	A	T	MI.16966	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	308	103	Q	L	cAa/cTa	5.6	1	0	probably_damaging	1	neutral	0.7	neutral	1.59	neutral	0.02	deleterious	-5.28	medium_impact	2.62	0.68	neutral	0.14	damaging	3.43	23.00	deleterious	0.11	0.4	NA	NA	0.8	disease	0.54	disease	0.51	disease	0	1	deleterious	0.35	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.41	medium_impact	1.47	medium_impact	0.12	0.8	46.84	9.32	0.47	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11068	11068	A	C	MI.16967	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	309	103	Q	H	caA/caC	8.59	1	0	probably_damaging	1	neutral	0.54	neutral	1.37	neutral	-2.93	deleterious	-3.43	high_impact	3.51	0.77	neutral	0.17	damaging	3.25	22.80	deleterious	0.24	0.45	NA	NA	0.79	disease	0.7	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.24	medium_impact	2.35	high_impact	0.39	0.8	46.84	9.32	0.53	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11068	11068	A	T	MI.16968	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	309	103	Q	H	caA/caT	8.59	1	0	probably_damaging	1	neutral	0.54	neutral	1.37	neutral	-2.93	deleterious	-3.43	high_impact	3.51	0.77	neutral	0.17	damaging	3.34	22.90	deleterious	0.24	0.45	NA	NA	0.79	disease	0.7	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.54	low_impact	0.24	medium_impact	2.35	high_impact	0.39	0.8	46.84	9.32	0.54	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11069	11069	A	T	MI.16969	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	310	104	I	F	Atc/Ttc	2.14	0.94	0.01	possibly_damaging	0.49	neutral	0.57	neutral	1.45	neutral	0.6	neutral	-1.39	medium_impact	2.02	0.71	neutral	0.79	neutral	0.71	8.90	deleterious	0.18	0.45	NA	NA	0.43	neutral	0.31	neutral	0.19	neutral	6	0.45	neutral	0.54	deleterious	0	NA	0.51	deleterious	-0.7	medium_impact	0.27	medium_impact	0.87	medium_impact	0.40	0.8	24.62	22.4	0.38	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8486	8486	C	G	MI.1697	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	121	41	P	A	Ccc/Gcc	-0.8	0	0	benign	0.07	neutral	0.74	neutral	1.55	neutral	-0.86	neutral	-0.73	low_impact	1.08	0.99	neutral	0.86	neutral	-1.16	0.01	neutral	0.58788784	0.85	0.22	neutral	0.02	neutral	0.39	neutral	0.05	neutral	9	0.17	neutral	0.84	deleterious	-6	neutral	0.10	neutral	0.31	medium_impact	0.55	medium_impact	-0.17	medium_impact	0.66	0.85	13.24	9.24	0.44	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11069	11069	A	G	MI.16970	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	310	104	I	V	Atc/Gtc	2.14	0.94	0.01	benign	0.01	neutral	0.24	neutral	1.56	neutral	0.13	neutral	-0.1	low_impact	1.78	0.79	neutral	0.98	neutral	-0.93	0.02	neutral	0.43	0.55	NA	NA	0.15	neutral	0.31	neutral	0.23	neutral	5	0.76	neutral	0.62	deleterious	-6	neutral	0.09	neutral	1.16	medium_impact	-0.08	medium_impact	0.64	medium_impact	0.43	0.8	24.62	22.4	0.45	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11069	11069	A	C	MI.16971	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	310	104	I	L	Atc/Ctc	2.14	0.94	0.01	benign	0.02	neutral	0.81	neutral	1.7	neutral	1.22	neutral	-0.13	neutral_impact	0.72	0.71	neutral	0.97	neutral	-0.91	0.02	neutral	0.3	0.45	NA	NA	0.22	neutral	0.23	neutral	0.16	neutral	7	0.15	neutral	0.9	deleterious	-6	neutral	0.13	neutral	0.87	medium_impact	0.56	medium_impact	-0.41	medium_impact	0.50	0.8	24.62	22.4	0.39	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11070	11070	T	G	MI.16972	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	311	104	I	S	aTc/aGc	-4.78	0	0	benign	0.36	deleterious	0.01	neutral	1.44	neutral	-0.56	neutral	-1.59	medium_impact	2.48	0.77	neutral	0.81	neutral	2.25	17.82	deleterious	0.09	0.35	NA	NA	0.54	disease	0.44	neutral	0.48	neutral	0	0.99	deleterious	0.33	neutral	1	deleterious	0.31	neutral	-0.48	medium_impact	-0.92	medium_impact	1.33	medium_impact	0.20	0.8	24.62	22.4	0.39	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11070	11070	T	C	MI.16973	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	311	104	I	T	aTc/aCc	-4.78	0	0	benign	0.02	neutral	0.29	neutral	1.52	neutral	-0.04	neutral	-0.55	neutral_impact	0.68	0.72	neutral	0.99	neutral	-0.69	0.08	neutral	0.19	0.45	NA	NA	0.17	neutral	0.29	neutral	0.22	neutral	6	0.7	neutral	0.64	deleterious	-6	neutral	0.09	neutral	0.87	medium_impact	-0.02	medium_impact	-0.45	medium_impact	0.23	0.8	24.62	22.4	0.48	N	0.97	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11070	11070	T	A	MI.16974	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	311	104	I	N	aTc/aAc	-4.78	0	0	possibly_damaging	0.68	deleterious	0.01	neutral	1.38	deleterious	-3.1	deleterious	-2.58	medium_impact	2.83	0.75	neutral	0.49	neutral	2.86	21.70	deleterious	0.2	0.45	NA	NA	0.58	disease	0.45	neutral	0.49	neutral	0	0.99	deleterious	0.17	neutral	4	deleterious	0.51	deleterious	-1.03	low_impact	-0.92	medium_impact	1.67	medium_impact	0.21	0.8	24.62	22.4	0.41	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11071	11071	C	A	MI.16975	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	312	104	I	M	atC/atA	-0.17	0	0	possibly_damaging	0.75	neutral	0.3	neutral	1.41	neutral	-1.03	neutral	-0.57	medium_impact	2.27	0.71	neutral	0.75	neutral	1.77	14.82	neutral	0.39	0.5	NA	NA	0.22	neutral	0.29	neutral	0.16	neutral	7	0.8	neutral	0.28	neutral	0	NA	0.50	deleterious	-1.17	low_impact	0	medium_impact	1.12	medium_impact	0.62	0.8	24.62	22.4	0.5	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11071	11071	C	G	MI.16976	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	312	104	I	M	atC/atG	-0.17	0	0	possibly_damaging	0.75	neutral	0.3	neutral	1.41	neutral	-1.03	neutral	-0.57	medium_impact	2.27	0.71	neutral	0.75	neutral	1.37	12.63	neutral	0.39	0.5	NA	NA	0.22	neutral	0.29	neutral	0.16	neutral	7	0.8	neutral	0.28	neutral	0	NA	0.50	deleterious	-1.17	low_impact	0	medium_impact	1.12	medium_impact	0.62	0.8	24.62	22.4	0.5	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11072	11072	T	A	MI.16977	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	313	105	S	T	Tcc/Acc	-13.08	0	0	benign	0.04	neutral	0.15	neutral	1.54	neutral	-0.98	neutral	-0.27	neutral_impact	0.56	0.7	neutral	0.84	neutral	2.53	19.68	deleterious	0.32	0.5	NA	NA	0.26	neutral	0.35	neutral	0.16	neutral	7	0.84	neutral	0.56	deleterious	-6	neutral	0.69	deleterious	0.58	medium_impact	-0.22	medium_impact	-0.57	medium_impact	0.56	0.8	27.67	26.85	0.49	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11072	11072	T	C	MI.16978	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	313	105	S	P	Tcc/Ccc	-13.08	0	0	possibly_damaging	0.81	deleterious	0.03	neutral	1.43	deleterious	-3.85	neutral	-1.85	medium_impact	2.11	0.52	damaging	0.44	neutral	3.80	23.40	deleterious	0.04	0.35	NA	NA	0.86	disease	0.66	disease	0.81	disease	6	0.98	deleterious	0.11	neutral	4	deleterious	0.84	deleterious	-1.31	low_impact	-0.64	medium_impact	0.96	medium_impact	0.23	0.8	27.67	26.85	0.4	N	0.76	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11072	11072	T	G	MI.16979	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	313	105	S	A	Tcc/Gcc	-13.08	0	0	benign	0.36	neutral	0.35	neutral	1.59	neutral	0.55	neutral	-0.24	low_impact	1.07	0.77	neutral	0.84	neutral	2.41	18.91	deleterious	0.3	0.45	NA	NA	0.26	neutral	0.35	neutral	0.16	neutral	7	0.58	neutral	0.5	deleterious	-6	neutral	0.69	deleterious	-0.48	medium_impact	0.05	medium_impact	-0.07	medium_impact	0.41	0.8	27.67	26.85	0.41	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8486	8486	C	T	MI.1698	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	121	41	P	S	Ccc/Tcc	-0.8	0	0	benign	0.07	neutral	0.68	neutral	1.55	neutral	-0.66	neutral	-0.44	neutral_impact	-0.02	0.99	neutral	0.97	neutral	-0.43	0.33	neutral	0.68116519	0.85	0.14	neutral	0.03	neutral	0.36	neutral	0.03	neutral	9	0.23	neutral	0.81	deleterious	-6	neutral	0.09	neutral	0.31	medium_impact	0.48	medium_impact	-1.12	low_impact	0.27	0.85	13.24	9.24	0.44	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11073	11073	C	G	MI.16980	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	314	105	S	C	tCc/tGc	-0.63	0	0	probably_damaging	0.95	neutral	0.09	neutral	1.44	deleterious	-3.62	neutral	-0.73	low_impact	1.76	0.74	neutral	0.53	neutral	3.45	23.00	deleterious	0.07	0.35	NA	NA	0.67	disease	0.59	disease	0.73	disease	5	0.98	deleterious	0.07	neutral	-2	neutral	0.75	deleterious	-1.92	low_impact	-0.36	medium_impact	0.62	medium_impact	0.28	0.8	27.67	26.85	0.4	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11073	11073	C	T	MI.16981	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	314	105	S	F	tCc/tTc	-0.63	0	0	benign	0.04	neutral	1	neutral	1.59	neutral	-2.21	neutral	2.39	neutral_impact	-0.5	0.7	neutral	0.98	neutral	1.43	12.97	neutral	0.06	0.35	NA	NA	0.24	neutral	0.39	neutral	0.16	neutral	7	0.04	neutral	0.98	deleterious	-6	neutral	0.70	deleterious	0.58	medium_impact	1.88	high_impact	-1.62	low_impact	0.11	0.8	27.67	26.85	0.3	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11073	11073	C	A	MI.16982	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	314	105	S	Y	tCc/tAc	-0.63	0	0	possibly_damaging	0.61	deleterious	0.01	neutral	1.45	deleterious	-3.18	neutral	1.03	medium_impact	2.11	0.72	neutral	0.59	neutral	3.99	23.60	deleterious	0.05	0.35	NA	NA	0.68	disease	0.57	disease	0.72	disease	4	0.99	deleterious	0.2	neutral	4	deleterious	0.77	deleterious	-0.9	medium_impact	-0.92	medium_impact	0.96	medium_impact	0.30	0.8	27.67	26.85	0.43	N	0.42	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11075	11075	T	A	MI.16983	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	316	106	L	M	Tta/Ata	-5.47	0	0	probably_damaging	1	deleterious	0.04	neutral	0.03	deleterious	-5.89	neutral	-1.55	medium_impact	3.1	0.49	damaging	0.09	damaging	3.52	23.10	deleterious	0.27	0.45	NA	NA	0.52	disease	0.57	disease	0.63	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-3.54	low_impact	-0.57	medium_impact	1.94	medium_impact	0.38	0.8	47.28	9.38	0.35	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11075	11075	T	G	MI.16984	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	316	106	L	V	Tta/Gta	-5.47	0	0	probably_damaging	1	deleterious	0.04	neutral	0.07	deleterious	-5.04	neutral	-2.32	medium_impact	3.44	0.52	damaging	0.09	damaging	3.29	22.80	deleterious	0.28	0.45	NA	NA	0.53	disease	0.59	disease	0.64	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-0.57	medium_impact	2.28	high_impact	0.46	0.8	47.28	9.38	0.33	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11076	11076	T	C	MI.16985	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	317	106	L	S	tTa/tCa	-0.17	0	0	probably_damaging	1	neutral	0.08	neutral	-0.01	deleterious	-7.8	deleterious	-4.64	medium_impact	3.44	0.47	damaging	0.1	damaging	3.63	23.20	deleterious	0.07	0.35	NA	NA	0.7	disease	0.63	disease	0.67	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.39	medium_impact	2.28	high_impact	0.19	0.8	47.28	9.38	0.32	N	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11076	11076	T	G	MI.16986	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	317	106	L	W	tTa/tGa	-0.17	0	0	probably_damaging	1	deleterious	0	neutral	-0.02	deleterious	-9.45	deleterious	-4.64	medium_impact	3.44	0.48	damaging	0.06	damaging	3.62	23.20	deleterious	0.06	0.35	NA	NA	0.71	disease	0.69	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.19	0.8	47.28	9.38	0.36	N	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11077	11077	A	T	MI.16987	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	318	106	L	F	ttA/ttT	5.83	0.88	0	probably_damaging	1	neutral	0.06	neutral	0.02	deleterious	-6.25	deleterious	-3.09	medium_impact	3.44	0.49	damaging	0.07	damaging	3.48	23.10	deleterious	0.18	0.45	NA	NA	0.63	disease	0.66	disease	0.68	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.47	medium_impact	2.28	high_impact	0.44	0.8	47.28	9.38	0.5	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11077	11077	A	C	MI.16988	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	318	106	L	F	ttA/ttC	5.83	0.88	0	probably_damaging	1	neutral	0.06	neutral	0.02	deleterious	-6.25	deleterious	-3.09	medium_impact	3.44	0.49	damaging	0.07	damaging	3.34	22.90	deleterious	0.18	0.45	NA	NA	0.63	disease	0.66	disease	0.68	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.47	medium_impact	2.28	high_impact	0.44	0.8	47.28	9.38	0.49	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11078	11078	A	G	MI.16989	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	319	107	I	V	Att/Gtt	-3.17	0	0	benign	0.08	neutral	0.46	neutral	1.49	neutral	-0.06	neutral	-0.7	medium_impact	2.08	0.79	neutral	0.92	neutral	1.83	15.18	deleterious	0.63	0.7	NA	NA	0.3	neutral	0.42	neutral	0.16	neutral	7	0.48	neutral	0.69	deleterious	-3	neutral	0.65	deleterious	0.28	medium_impact	0.16	medium_impact	0.93	medium_impact	0.40	0.8	22	8.45	0.36	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8486	8486	C	A	MI.1699	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	121	41	P	T	Ccc/Acc	-0.8	0	0	benign	0	neutral	0.59	neutral	1.56	neutral	-0.57	neutral	-0.14	neutral_impact	0.21	1	neutral	0.97	neutral	-0.12	1.60	neutral	0.61638548	0.85	0.16	neutral	0.05	neutral	0.23	neutral	0.04	neutral	9	0.41	neutral	0.8	deleterious	-6	neutral	0.07	neutral	2.09	high_impact	0.38	medium_impact	-0.92	medium_impact	0.62	0.85	13.24	9.24	0.44	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11078	11078	A	T	MI.16990	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	319	107	I	F	Att/Ttt	-3.17	0	0	probably_damaging	0.96	neutral	0.31	neutral	1.36	neutral	-1.93	deleterious	-2.67	medium_impact	3.31	0.7	neutral	0.5	neutral	3.60	23.20	deleterious	0.22	0.45	NA	NA	0.69	disease	0.46	neutral	0.51	disease	0	0.96	neutral	0.18	neutral	1	deleterious	0.79	deleterious	-2.01	low_impact	0.01	medium_impact	2.15	high_impact	0.48	0.8	22	8.45	0.43	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11078	11078	A	C	MI.16991	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	319	107	I	L	Att/Ctt	-3.17	0	0	possibly_damaging	0.52	neutral	0.46	neutral	1.49	neutral	0.8	neutral	-1.32	medium_impact	2.04	0.74	neutral	0.71	neutral	3.59	23.20	deleterious	0.28	0.45	NA	NA	0.5	neutral	0.38	neutral	0.44	neutral	1	0.54	neutral	0.47	deleterious	0	NA	0.68	deleterious	-0.75	medium_impact	0.16	medium_impact	0.89	medium_impact	0.51	0.8	22	8.45	0.4	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11079	11079	T	C	MI.16992	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	320	107	I	T	aTt/aCt	0.75	0.15	0	possibly_damaging	0.83	neutral	0.05	neutral	1.33	neutral	-1.84	deleterious	-3.58	medium_impact	2.42	0.74	neutral	0.72	neutral	3.29	22.80	deleterious	0.11	0.4	NA	NA	0.6	disease	0.48	neutral	0.46	neutral	1	0.97	neutral	0.11	neutral	0	NA	0.76	deleterious	-1.37	low_impact	-0.52	medium_impact	1.27	medium_impact	0.20	0.8	22	8.45	0.46	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11079	11079	T	G	MI.16993	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	320	107	I	S	aTt/aGt	0.75	0.15	0	probably_damaging	0.94	neutral	0.08	neutral	1.3	neutral	-2.32	deleterious	-4.37	medium_impact	2.97	0.72	neutral	0.62	neutral	4.14	23.80	deleterious	0.03	0.35	NA	NA	0.76	disease	0.54	disease	0.52	disease	0	0.98	deleterious	0.07	neutral	1	deleterious	0.80	deleterious	-1.84	low_impact	-0.39	medium_impact	1.81	medium_impact	0.16	0.8	22	8.45	0.42	N	0.95	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11079	11079	T	A	MI.16994	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	320	107	I	N	aTt/aAt	0.75	0.15	0	probably_damaging	0.98	deleterious	0.01	neutral	1.27	neutral	-1.66	deleterious	-5.14	medium_impact	3.31	0.66	neutral	0.48	neutral	4.38	24.10	deleterious	0.09	0.35	NA	NA	0.78	disease	0.63	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.81	deleterious	-2.31	low_impact	-0.92	medium_impact	2.15	high_impact	0.19	0.8	22	8.45	0.4	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11080	11080	T	A	MI.16995	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	321	107	I	M	atT/atA	5.6	0.88	0.01	probably_damaging	0.96	neutral	0.13	neutral	1.32	neutral	-0.94	neutral	-2.05	medium_impact	2.62	0.73	neutral	0.63	neutral	3.62	23.20	deleterious	0.38	0.5	NA	NA	0.55	disease	0.53	disease	0.47	neutral	1	0.98	neutral	0.09	neutral	1	deleterious	0.75	deleterious	-2.01	low_impact	-0.26	medium_impact	1.47	medium_impact	0.49	0.8	22	8.45	0.53	P	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11080	11080	T	G	MI.16996	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	321	107	I	M	atT/atG	5.6	0.88	0.01	probably_damaging	0.96	neutral	0.13	neutral	1.32	neutral	-0.94	neutral	-2.05	medium_impact	2.62	0.73	neutral	0.63	neutral	3.30	22.80	deleterious	0.38	0.5	NA	NA	0.55	disease	0.53	disease	0.47	neutral	1	0.98	neutral	0.09	neutral	1	deleterious	0.75	deleterious	-2.01	low_impact	-0.26	medium_impact	1.47	medium_impact	0.49	0.8	22	8.45	0.53	P	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11081	11081	A	C	MI.16997	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	322	108	M	L	Ata/Cta	-5.24	0	0	benign	0.01	neutral	1	neutral	1.8	neutral	0.55	neutral	-1.53	neutral_impact	0.57	0.69	neutral	0.87	neutral	1.30	12.26	neutral	0.36	0.5	NA	NA	0.3	neutral	0.35	neutral	0.17	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.51	deleterious	1.16	medium_impact	1.88	high_impact	-0.56	medium_impact	0.23	0.8	15.9	15.73	0.27	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11081	11081	A	G	MI.16998	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	322	108	M	V	Ata/Gta	-5.24	0	0	benign	0.18	neutral	0.18	neutral	1.57	neutral	-0.44	deleterious	-2.59	medium_impact	2.56	0.81	neutral	0.61	neutral	2.55	19.78	deleterious	0.28	0.45	NA	NA	0.66	disease	0.46	neutral	0.48	neutral	1	0.79	neutral	0.5	deleterious	-3	neutral	0.65	deleterious	-0.1	medium_impact	-0.17	medium_impact	1.41	medium_impact	0.33	0.8	15.9	15.73	0.34	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11081	11081	A	T	MI.16999	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	322	108	M	L	Ata/Tta	-5.24	0	0	benign	0.01	neutral	1	neutral	1.8	neutral	0.55	neutral	-1.53	neutral_impact	0.57	0.69	neutral	0.87	neutral	1.37	12.63	neutral	0.36	0.5	NA	NA	0.3	neutral	0.35	neutral	0.17	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.51	deleterious	1.16	medium_impact	1.88	high_impact	-0.56	medium_impact	0.23	0.8	15.9	15.73	0.27	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8534	8534	A	C	MI.17	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	8	3	E	A	gAa/gCa	-0.1	0.06	0	probably_damaging	0.95	neutral	0.6	neutral	4.7	neutral	0.11	neutral	-2.42	neutral_impact	0.72	0.86	neutral	0.6	neutral	3.42	23.00	deleterious	0.61	0.7	0.54	disease	0.1	neutral	0.28	neutral	0.35	neutral	3	0.95	neutral	0.33	neutral	-2	neutral	0.63	deleterious	-1.97	low_impact	0.39	medium_impact	-0.48	medium_impact	0.80	0.9	15.93	14.48	0.25	N	0.74	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8605	8605	C	G	MI.170	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	79	27	P	A	Ccc/Gcc	-6.58	0	0	probably_damaging	1	neutral	0.51	neutral	4.46	neutral	0.91	deleterious	-7	medium_impact	2.82	0.73	neutral	0.55	neutral	2.92	21.90	deleterious	0.35	0.65	0.44	neutral	0.54	disease	0.57	disease	0.57	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.3	medium_impact	1.32	medium_impact	0.61	0.9	48.23	8.81	0.31	N	0.79	polymorphism	0.83	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8487	8487	C	T	MI.1700	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	122	41	P	L	cCc/cTc	-6.81	0	0	benign	0.07	neutral	0.75	neutral	1.53	neutral	-1.58	neutral	-0.62	neutral_impact	-0.46	1	neutral	0.91	neutral	0.88	9.98	deleterious	0.62290357	0.85	0.36	neutral	0.04	neutral	0.38	neutral	0.03	neutral	9	0.16	neutral	0.84	deleterious	-6	neutral	0.11	neutral	0.31	medium_impact	0.56	medium_impact	-1.49	low_impact	0.72	0.85	13.24	9.24	0.41	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11082	11082	T	C	MI.17000	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	323	108	M	T	aTa/aCa	0.52	0.04	0	benign	0.03	deleterious	0.02	neutral	1.46	neutral	-1.96	deleterious	-4.13	medium_impact	2.56	0.8	neutral	0.61	neutral	2.73	21.00	deleterious	0.13	0.4	NA	NA	0.64	disease	0.6	disease	0.55	disease	1	0.98	neutral	0.5	deleterious	1	deleterious	0.75	deleterious	0.7	medium_impact	-0.75	medium_impact	1.41	medium_impact	0.10	0.8	15.9	15.73	0.4	N	0.90	polymorphism	1	0.11	.	.	.	.	.	.	COSM5655027	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11082	11082	T	A	MI.17001	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	323	108	M	K	aTa/aAa	0.52	0.04	0	benign	0.34	deleterious	0.01	neutral	1.42	deleterious	-3.59	deleterious	-4.3	medium_impact	2.9	0.71	neutral	0.37	neutral	3.71	23.30	deleterious	0.03	0.35	NA	NA	0.86	disease	0.68	disease	0.79	disease	6	0.99	deleterious	0.34	neutral	1	deleterious	0.83	deleterious	-0.45	medium_impact	-0.92	medium_impact	1.74	medium_impact	0.17	0.8	15.9	15.73	0.35	N	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11083	11083	A	T	MI.17002	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	324	108	M	I	atA/atT	3.75	0.42	0	benign	0.27	neutral	0.21	neutral	1.56	neutral	-0.57	neutral	-2.44	low_impact	1.49	0.77	neutral	0.65	neutral	3.28	22.80	deleterious	0.34	0.5	NA	NA	0.69	disease	0.43	neutral	0.52	disease	0	0.75	neutral	0.47	deleterious	-6	neutral	0.71	deleterious	-0.31	medium_impact	-0.12	medium_impact	0.35	medium_impact	0.34	0.8	15.9	15.73	0.39	N	0.83	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11083	11083	A	C	MI.17003	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	324	108	M	I	atA/atC	3.75	0.42	0	benign	0.27	neutral	0.21	neutral	1.56	neutral	-0.57	neutral	-2.44	low_impact	1.49	0.77	neutral	0.65	neutral	3.24	22.80	deleterious	0.34	0.5	NA	NA	0.69	disease	0.43	neutral	0.52	disease	0	0.75	neutral	0.47	deleterious	-6	neutral	0.71	deleterious	-0.31	medium_impact	-0.12	medium_impact	0.35	medium_impact	0.34	0.8	15.9	15.73	0.38	N	0.83	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11084	11084	A	T	MI.17004	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	325	109	T	S	Aca/Tca	-0.86	0	0.08	possibly_damaging	0.89	neutral	0.27	neutral	1.17	neutral	-2.5	neutral	-1.67	medium_impact	2.79	0.72	neutral	0.61	neutral	3.12	22.60	deleterious	0.49	0.55	NA	NA	0.65	disease	0.44	neutral	0.48	neutral	1	0.92	neutral	0.19	neutral	0	NA	0.76	deleterious	-1.57	low_impact	-0.04	medium_impact	1.63	medium_impact	0.65	0.8	17.65	20.11	0.49	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11084	11084	A	G	MI.17005	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	325	109	T	A	Aca/Gca	-0.86	0	0.08	possibly_damaging	0.81	neutral	1	neutral	1.3	neutral	-1.26	neutral	-1.32	low_impact	1.1	0.27	damaging	0.76	neutral	0.62	8.31	deleterious	0.34	0.5	NA	NA	0.12	neutral	0.34	neutral	0.21	neutral	6	0.81	neutral	0.6	deleterious	-3	neutral	0.66	deleterious	-1.31	low_impact	1.88	high_impact	-0.04	medium_impact	0.28	0.8	17.65	20.11	0.94	P	0.59	disease_causing_automatic	0	0.03	rs199476113	Pathogenic	Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke	24748	MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003	.	.	.	.	A11084G	AD, PD, MELAS	+	+	Conflicting reports	6	P	N	P,N	neutral
chrM	11084	11084	A	C	MI.17006	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	325	109	T	P	Aca/Cca	-0.86	0	0.08	probably_damaging	0.98	deleterious	0.04	neutral	1.08	deleterious	-5.03	deleterious	-3.22	medium_impact	3.14	0.84	neutral	0.36	neutral	3.35	22.90	deleterious	0.04	0.35	NA	NA	0.92	disease	0.74	disease	0.83	disease	7	1	deleterious	0.03	neutral	5	deleterious	0.84	deleterious	-2.31	low_impact	-0.57	medium_impact	1.98	medium_impact	0.40	0.8	17.65	20.11	0.39	N	0.97	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11085	11085	C	T	MI.17007	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	326	109	T	M	aCa/aTa	3.52	1	0	possibly_damaging	0.61	neutral	0.06	neutral	1.11	deleterious	-3.82	deleterious	-3.22	medium_impact	3.14	0.78	neutral	0.55	neutral	3.84	23.40	deleterious	0.11	0.4	NA	NA	0.81	disease	0.58	disease	0.75	disease	5	0.94	neutral	0.23	neutral	0	NA	0.78	deleterious	-0.9	medium_impact	-0.47	medium_impact	1.98	medium_impact	0.56	0.8	17.65	20.11	0.56	P	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11085	11085	C	A	MI.17008	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	326	109	T	K	aCa/aAa	3.52	1	0	probably_damaging	0.96	neutral	0.05	neutral	1.1	deleterious	-3.88	deleterious	-3.22	medium_impact	3.14	0.79	neutral	0.41	neutral	4.44	24.20	deleterious	0.07	0.35	NA	NA	0.91	disease	0.73	disease	0.82	disease	6	0.99	deleterious	0.05	neutral	1	deleterious	0.85	deleterious	-2.01	low_impact	-0.52	medium_impact	1.98	medium_impact	0.46	0.8	17.65	20.11	0.51	N	0.93	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11087	11087	T	C	MI.17009	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	328	110	F	L	Ttc/Ctc	-6.16	0	0.01	probably_damaging	1	deleterious	0.01	neutral	2.07	neutral	-1.68	deleterious	-4.63	high_impact	3.68	0.55	damaging	0.67	neutral	3.88	23.50	deleterious	0.16	0.45	NA	NA	0.81	disease	0.63	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	2.52	high_impact	0.66	0.8	46.84	9.26	0.41	N	0.91	polymorphism	1	0.25	rs28433448	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8487	8487	C	A	MI.1701	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	122	41	P	H	cCc/cAc	-6.81	0	0	possibly_damaging	0.73	neutral	0.58	neutral	1.55	neutral	-0.77	neutral	-1.86	low_impact	1.32	0.98	neutral	0.67	neutral	2.46	19.18	deleterious	0.63950197	0.85	0.44	neutral	0.06	neutral	0.53	disease	0.14	neutral	7	0.69	neutral	0.43	neutral	-3	neutral	0.46	deleterious	-1.17	low_impact	0.37	medium_impact	0.03	medium_impact	0.50	0.85	13.24	9.24	0.41	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11087	11087	T	G	MI.17010	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	328	110	F	V	Ttc/Gtc	-6.16	0	0.01	probably_damaging	1	deleterious	0	neutral	2.36	neutral	-0.33	deleterious	-5.41	high_impact	4.24	0.61	neutral	0.65	neutral	3.96	23.60	deleterious	0.09	0.35	NA	NA	0.87	disease	0.63	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.07	high_impact	0.35	0.8	46.84	9.26	0.45	N	0.96	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11087	11087	T	A	MI.17011	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	328	110	F	I	Ttc/Atc	-6.16	0	0.01	probably_damaging	1	deleterious	0	neutral	2.06	neutral	-1.92	deleterious	-4.63	high_impact	4.93	0.63	neutral	0.73	neutral	4.25	23.90	deleterious	0.13	0.4	NA	NA	0.86	disease	0.69	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.75	high_impact	0.41	0.8	46.84	9.26	0.71	P	0.96	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11088	11088	T	A	MI.17012	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	329	110	F	Y	tTc/tAc	7.44	1	0	probably_damaging	1	neutral	0.05	neutral	1.96	deleterious	-4.17	neutral	-2.32	high_impact	4.58	0.66	neutral	0.58	neutral	4.20	23.90	deleterious	0.14	0.4	NA	NA	0.77	disease	0.72	disease	0.73	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.83	deleterious	-3.54	low_impact	-0.52	medium_impact	3.41	high_impact	0.62	0.8	46.84	9.26	0.68	P	0.88	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11088	11088	T	C	MI.17013	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	329	110	F	S	tTc/tCc	7.44	1	0	probably_damaging	1	deleterious	0	neutral	1.98	deleterious	-3.06	deleterious	-6.18	high_impact	4.93	0.59	damaging	0.78	neutral	4.16	23.80	deleterious	0.03	0.35	NA	NA	0.84	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.75	high_impact	0.20	0.8	46.84	9.26	0.66	P	0.95	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11088	11088	T	G	MI.17014	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	329	110	F	C	tTc/tGc	7.44	1	0	probably_damaging	1	deleterious	0	neutral	1.95	deleterious	-4.69	deleterious	-6.18	high_impact	4.93	0.66	neutral	0.59	neutral	3.96	23.60	deleterious	0.03	0.35	NA	NA	0.85	disease	0.73	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.75	high_impact	0.31	0.8	46.84	9.26	0.65	P	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11089	11089	C	A	MI.17015	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	330	110	F	L	ttC/ttA	5.83	1	0	probably_damaging	1	deleterious	0.01	neutral	2.07	neutral	-1.68	deleterious	-4.63	high_impact	3.68	0.55	damaging	0.67	neutral	4.43	24.20	deleterious	0.16	0.45	NA	NA	0.81	disease	0.63	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	2.52	high_impact	0.66	0.8	46.84	9.26	0.62	P	0.91	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11089	11089	C	G	MI.17016	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	330	110	F	L	ttC/ttG	5.83	1	0	probably_damaging	1	deleterious	0.01	neutral	2.07	neutral	-1.68	deleterious	-4.63	high_impact	3.68	0.55	damaging	0.67	neutral	4.14	23.80	deleterious	0.16	0.45	NA	NA	0.81	disease	0.63	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	2.52	high_impact	0.66	0.8	46.84	9.26	0.62	P	0.91	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11090	11090	A	T	MI.17017	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	331	111	T	S	Aca/Tca	-4.32	0	0	benign	0.01	neutral	1	neutral	2.25	neutral	0	neutral	0.04	neutral_impact	-1.35	0.76	neutral	1	neutral	0.38	6.40	deleterious	0.37	0.5	NA	NA	0.09	neutral	0.21	neutral	0.23	neutral	5	0.01	neutral	1	deleterious	-6	neutral	0.66	deleterious	1.16	medium_impact	1.88	high_impact	-2.46	low_impact	0.68	0.85	25.93	24.56	0.31	N	0.00	polymorphism	1	0.00	.	.	.	.	.	pituitary adenoma	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11090	11090	A	G	MI.17018	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	331	111	T	A	Aca/Gca	-4.32	0	0	benign	0.12	neutral	0.32	neutral	2.17	neutral	-0.27	neutral	-1.06	neutral_impact	0.41	0.72	neutral	0.96	neutral	2.08	16.75	deleterious	0.22	0.45	NA	NA	0.47	neutral	0.36	neutral	0.25	neutral	5	0.63	neutral	0.6	deleterious	-6	neutral	0.73	deleterious	0.1	medium_impact	0.02	medium_impact	-0.72	medium_impact	0.36	0.8	25.93	24.56	0.4	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11090	11090	A	C	MI.17019	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	331	111	T	P	Aca/Cca	-4.32	0	0	possibly_damaging	0.51	neutral	0.11	neutral	2.05	deleterious	-3.87	neutral	-2.4	medium_impact	2.25	0.71	neutral	0.39	neutral	3.33	22.90	deleterious	0.05	0.35	NA	NA	0.9	disease	0.71	disease	0.82	disease	6	0.88	neutral	0.3	neutral	0	NA	0.85	deleterious	-0.73	medium_impact	-0.31	medium_impact	1.1	medium_impact	0.44	0.8	25.93	24.56	0.34	N	0.68	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8487	8487	C	G	MI.1702	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	122	41	P	R	cCc/cGc	-6.81	0	0	benign	0.29	neutral	0.5	neutral	1.8	neutral	1.84	neutral	-1.69	low_impact	1.77	1	neutral	0.4	neutral	-0.10	1.72	neutral	0.54615447	0.85	0.29	neutral	0.08	neutral	0.48	neutral	0.05	neutral	9	0.4	neutral	0.61	deleterious	-6	neutral	0.22	neutral	-0.39	medium_impact	0.29	medium_impact	0.42	medium_impact	0.55	0.85	13.24	9.24	0.44	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11091	11091	C	T	MI.17020	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	332	111	T	M	aCa/aTa	-1.78	0	0	benign	0.01	neutral	0.29	neutral	2.11	neutral	-1.28	neutral	-2.45	neutral_impact	0.02	0.74	neutral	0.75	neutral	2.73	21.00	deleterious	0.13	0.4	NA	NA	0.62	disease	0.36	neutral	0.47	neutral	1	0.7	neutral	0.64	deleterious	-6	neutral	0.76	deleterious	1.16	medium_impact	-0.02	medium_impact	-1.11	low_impact	0.62	0.8	25.93	24.56	0.4	N	0.16	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11091	11091	C	A	MI.17021	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	332	111	T	K	aCa/aAa	-1.78	0	0	benign	0.19	neutral	0.16	neutral	2.06	deleterious	-3.52	neutral	-2.08	medium_impact	2.11	0.73	neutral	0.47	neutral	4.33	24.00	deleterious	0.06	0.35	NA	NA	0.85	disease	0.7	disease	0.81	disease	6	0.81	neutral	0.49	deleterious	-3	neutral	0.83	deleterious	-0.13	medium_impact	-0.2	medium_impact	0.96	medium_impact	0.51	0.8	25.93	24.56	0.34	N	0.53	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11093	11093	G	A	MI.17022	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	334	112	A	T	Gcc/Acc	-15.85	0	0	possibly_damaging	0.83	neutral	0.4	neutral	4.26	deleterious	-3.42	deleterious	-2.61	neutral_impact	0.49	0.75	neutral	0.83	neutral	3.88	23.50	deleterious	0.16	0.45	NA	NA	0.67	disease	0.42	neutral	0.48	neutral	0	0.84	neutral	0.29	neutral	-3	neutral	0.72	deleterious	-1.37	low_impact	0.1	medium_impact	-0.64	medium_impact	0.75	0.85	16.12	14.73	0.39	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	COSM1155502	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11093	11093	G	T	MI.17023	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	334	112	A	S	Gcc/Tcc	-15.85	0	0	benign	0.2	neutral	0.86	neutral	5.06	neutral	1.2	neutral	-1.88	neutral_impact	0.56	0.75	neutral	0.85	neutral	1.92	15.70	deleterious	0.23	0.45	NA	NA	0.44	neutral	0.37	neutral	0.2	neutral	6	0.09	neutral	0.83	deleterious	-6	neutral	0.60	deleterious	-0.15	medium_impact	0.64	medium_impact	-0.57	medium_impact	0.57	0.8	16.12	14.73	0.32	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11093	11093	G	C	MI.17024	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	334	112	A	P	Gcc/Ccc	-15.85	0	0	probably_damaging	0.96	neutral	0.09	neutral	4.26	deleterious	-3.46	deleterious	-3.58	medium_impact	3.44	0.69	neutral	0.37	neutral	3.69	23.30	deleterious	0.02	0.35	NA	NA	0.93	disease	0.75	disease	0.87	disease	7	0.98	deleterious	0.07	neutral	1	deleterious	0.88	deleterious	-2.01	low_impact	-0.36	medium_impact	2.28	high_impact	0.55	0.8	16.12	14.73	0.38	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11094	11094	C	G	MI.17025	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	335	112	A	G	gCc/gGc	0.75	0.67	0	benign	0.08	deleterious	0	neutral	4.25	deleterious	-3.84	deleterious	-2.87	medium_impact	2.89	0.77	neutral	0.65	neutral	1.90	15.61	deleterious	0.17	0.45	NA	NA	0.85	disease	0.63	disease	0.74	disease	5	1	deleterious	0.46	neutral	1	deleterious	0.27	neutral	0.28	medium_impact	-1.48	low_impact	1.73	medium_impact	0.68	0.85	16.12	14.73	0.33	N	0.65	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11094	11094	C	A	MI.17026	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	335	112	A	D	gCc/gAc	0.75	0.67	0	possibly_damaging	0.89	deleterious	0	neutral	4.23	deleterious	-5.35	deleterious	-4.21	medium_impact	3.44	0.71	neutral	0.4	neutral	4.39	24.10	deleterious	0.02	0.35	NA	NA	0.93	disease	0.74	disease	0.86	disease	7	1	deleterious	0.06	neutral	4	deleterious	0.84	deleterious	-1.57	low_impact	-1.48	low_impact	2.28	high_impact	0.34	0.8	16.12	14.73	0.42	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11094	11094	C	T	MI.17027	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	335	112	A	V	gCc/gTc	0.75	0.67	0	possibly_damaging	0.88	neutral	0.44	neutral	4.3	neutral	-2.53	deleterious	-2.87	low_impact	0.82	0.74	neutral	0.64	neutral	4.11	23.70	deleterious	0.07	0.35	NA	NA	0.85	disease	0.58	disease	0.55	disease	1	0.87	neutral	0.28	neutral	-3	neutral	0.78	deleterious	-1.53	low_impact	0.14	medium_impact	-0.32	medium_impact	0.67	0.85	16.12	14.73	0.32	N	0.82	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11096	11096	A	G	MI.17028	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	337	113	T	A	Aca/Gca	-12.16	0	0	benign	0.05	neutral	0.21	neutral	4.65	neutral	-0.21	deleterious	-2.67	medium_impact	2.42	0.78	neutral	0.86	neutral	1.38	12.66	neutral	0.24	0.45	NA	NA	0.63	disease	0.57	disease	0.62	disease	2	0.77	neutral	0.58	deleterious	-3	neutral	0.20	neutral	0.48	medium_impact	-0.12	medium_impact	1.27	medium_impact	0.37	0.8	17.21	15.02	0.39	N	0.60	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11096	11096	A	T	MI.17029	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	337	113	T	S	Aca/Tca	-12.16	0	0	benign	0.13	neutral	0.64	neutral	4.77	neutral	-0.13	neutral	-1.78	neutral_impact	0.7	0.74	neutral	0.95	neutral	0.21	4.76	deleterious	0.35	0.5	NA	NA	0.43	neutral	0.34	neutral	0.19	neutral	6	0.25	neutral	0.76	deleterious	-6	neutral	0.29	neutral	0.06	medium_impact	0.34	medium_impact	-0.43	medium_impact	0.58	0.8	17.21	15.02	0.34	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8489	8489	A	G	MI.1703	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	124	42	M	V	Ata/Gta	-6.35	0	0	possibly_damaging	0.75	neutral	0.6	neutral	1.23	neutral	-2.4	neutral	-0.36	neutral_impact	0.76	1	neutral	0.93	neutral	-0.13	1.54	neutral	0.70671114	0.85	0.22	neutral	0.22	neutral	0.35	neutral	0.11	neutral	8	0.71	neutral	0.43	neutral	-3	neutral	0.35	neutral	-1.21	low_impact	0.39	medium_impact	-0.45	medium_impact	0.44	0.85	17.65	9.06	0.36	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11096	11096	A	C	MI.17030	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	337	113	T	P	Aca/Cca	-12.16	0	0	probably_damaging	0.93	neutral	0.09	neutral	4.61	neutral	-1.7	deleterious	-3.67	medium_impact	2.17	0.68	neutral	0.4	neutral	3.06	22.40	deleterious	0.06	0.35	NA	NA	0.9	disease	0.72	disease	0.8	disease	6	0.98	neutral	0.08	neutral	1	deleterious	0.74	deleterious	-1.77	low_impact	-0.36	medium_impact	1.02	medium_impact	0.30	0.8	17.21	15.02	0.35	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11097	11097	C	A	MI.17031	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	338	113	T	K	aCa/aAa	0.06	0	0	possibly_damaging	0.75	neutral	0.14	neutral	4.67	neutral	-0.34	deleterious	-3.49	low_impact	1.84	0.73	neutral	0.45	neutral	2.61	20.20	deleterious	0.11	0.4	NA	NA	0.91	disease	0.71	disease	0.8	disease	6	0.9	neutral	0.2	neutral	-3	neutral	0.52	deleterious	-1.17	low_impact	-0.24	medium_impact	0.69	medium_impact	0.51	0.8	17.21	15.02	0.35	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11097	11097	C	T	MI.17032	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	338	113	T	M	aCa/aTa	0.06	0	0	probably_damaging	0.96	neutral	0.42	neutral	4.61	neutral	-2.65	deleterious	-3.38	low_impact	1	0.8	neutral	0.93	neutral	2.69	20.70	deleterious	0.11	0.4	NA	NA	0.65	disease	0.39	neutral	0.47	neutral	1	0.96	neutral	0.23	neutral	-2	neutral	0.70	deleterious	-2.01	low_impact	0.12	medium_impact	-0.14	medium_impact	0.55	0.8	17.21	15.02	0.29	N	0.42	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11099	11099	G	A	MI.17033	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	340	114	E	K	Gaa/Aaa	-5.7	0	0	probably_damaging	1	deleterious	0.01	neutral	4.57	neutral	-0.51	deleterious	-3.07	medium_impact	2.05	0.69	neutral	0.45	neutral	4.32	24.00	deleterious	0.09	0.35	NA	NA	0.9	disease	0.77	disease	0.82	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.89	deleterious	-3.54	low_impact	-0.92	medium_impact	0.9	medium_impact	0.82	0.85	46.41	8.56	0.39	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11099	11099	G	C	MI.17034	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	340	114	E	Q	Gaa/Caa	-5.7	0	0	probably_damaging	1	deleterious	0.01	neutral	4.56	neutral	-0.95	neutral	-2.29	medium_impact	3.09	0.71	neutral	0.56	neutral	3.23	22.80	deleterious	0.16	0.45	NA	NA	0.73	disease	0.66	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.54	low_impact	-0.92	medium_impact	1.93	medium_impact	0.58	0.8	46.41	8.56	0.38	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11100	11100	A	T	MI.17035	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	341	114	E	V	gAa/gTa	3.75	1	0	probably_damaging	1	deleterious	0	neutral	4.53	neutral	-2.24	deleterious	-5.36	medium_impact	3.09	0.68	neutral	0.57	neutral	3.96	23.60	deleterious	0.04	0.35	NA	NA	0.89	disease	0.68	disease	0.77	disease	5	1	deleterious	0	neutral	5	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	1.93	medium_impact	0.26	0.8	46.41	8.56	0.5	P	0.80	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11100	11100	A	C	MI.17036	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	341	114	E	A	gAa/gCa	3.75	1	0	probably_damaging	1	deleterious	0.01	neutral	4.56	neutral	-0.89	deleterious	-4.59	medium_impact	3.09	0.74	neutral	0.62	neutral	3.53	23.10	deleterious	0.08	0.35	NA	NA	0.72	disease	0.66	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-3.54	low_impact	-0.92	medium_impact	1.93	medium_impact	0.28	0.8	46.41	8.56	0.57	P	0.74	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11100	11100	A	G	MI.17037	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	341	114	E	G	gAa/gGa	3.75	1	0	probably_damaging	1	neutral	0.05	neutral	4.56	neutral	-1.65	deleterious	-5.31	medium_impact	2.4	0.7	neutral	0.66	neutral	4.07	23.70	deleterious	0.11	0.4	NA	NA	0.84	disease	0.68	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.52	medium_impact	1.25	medium_impact	0.23	0.8	46.41	8.56	0.55	P	0.53	polymorphism	1	0.09	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11101	11101	A	T	MI.17038	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	342	114	E	D	gaA/gaT	8.59	1	0	probably_damaging	1	neutral	0.42	neutral	4.9	neutral	3.07	neutral	-2.15	neutral_impact	0.18	0.71	neutral	0.8	neutral	3.62	23.20	deleterious	0.21	0.45	NA	NA	0.59	disease	0.51	disease	0.44	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.81	deleterious	-3.54	low_impact	0.12	medium_impact	-0.95	medium_impact	0.62	0.8	46.41	8.56	0.61	P	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11101	11101	A	C	MI.17039	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	342	114	E	D	gaA/gaC	8.59	1	0	probably_damaging	1	neutral	0.42	neutral	4.9	neutral	3.07	neutral	-2.15	neutral_impact	0.18	0.71	neutral	0.8	neutral	3.52	23.10	deleterious	0.21	0.45	NA	NA	0.59	disease	0.51	disease	0.44	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.81	deleterious	-3.54	low_impact	0.12	medium_impact	-0.95	medium_impact	0.62	0.8	46.41	8.56	0.6	P	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8489	8489	A	T	MI.1704	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	124	42	M	L	Ata/Tta	-6.35	0	0	possibly_damaging	0.66	neutral	0.79	neutral	1.26	neutral	-1.98	neutral	-0.46	neutral_impact	0.18	1	neutral	0.94	neutral	1.32	12.36	neutral	0.62618842	0.85	0.12	neutral	0.17	neutral	0.32	neutral	0.07	neutral	9	0.59	neutral	0.57	deleterious	-3	neutral	0.30	neutral	-1.03	low_impact	0.62	medium_impact	-0.94	medium_impact	0.53	0.85	17.65	9.06	0.36	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11102	11102	C	A	MI.17040	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	343	115	L	M	Cta/Ata	-0.63	0	0	possibly_damaging	0.68	neutral	0.18	neutral	4.03	deleterious	-4.21	neutral	-0.37	medium_impact	2.19	0.77	neutral	0.83	neutral	2.43	19.03	deleterious	0.26	0.45	NA	NA	0.3	neutral	0.43	neutral	0.18	neutral	6	0.85	neutral	0.25	neutral	0	NA	0.70	deleterious	-1.03	low_impact	-0.17	medium_impact	1.04	medium_impact	0.73	0.85	14.6	9.81	0.47	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11102	11102	C	G	MI.17041	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	343	115	L	V	Cta/Gta	-0.63	0	0	possibly_damaging	0.86	neutral	0.19	neutral	4.15	neutral	-2.31	neutral	-1.22	medium_impact	2.5	0.7	neutral	0.27	damaging	2.08	16.71	deleterious	0.24	0.45	NA	NA	0.47	neutral	0.58	disease	0.39	neutral	2	0.92	neutral	0.17	neutral	0	NA	0.76	deleterious	-1.46	low_impact	-0.15	medium_impact	1.35	medium_impact	0.59	0.8	14.6	9.81	0.39	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11103	11103	T	G	MI.17042	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	344	115	L	R	cTa/cGa	-0.63	0	0	probably_damaging	0.98	deleterious	0	neutral	4.01	deleterious	-5.3	deleterious	-3.83	high_impact	4.12	0.69	neutral	0.1	damaging	4.07	23.70	deleterious	0.03	0.35	NA	NA	0.9	disease	0.77	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.31	low_impact	-1.48	low_impact	2.95	high_impact	0.15	0.8	14.6	9.81	0.46	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11103	11103	T	A	MI.17043	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	344	115	L	Q	cTa/cAa	-0.63	0	0	probably_damaging	0.98	deleterious	0	neutral	4.01	deleterious	-5.47	deleterious	-3.62	high_impact	4.12	0.71	neutral	0.09	damaging	4.10	23.70	deleterious	0.05	0.35	NA	NA	0.74	disease	0.66	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.31	low_impact	-1.48	low_impact	2.95	high_impact	0.26	0.8	14.6	9.81	0.38	N	0.94	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11103	11103	T	C	MI.17044	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	344	115	L	P	cTa/cCa	-0.63	0	0	probably_damaging	0.99	deleterious	0	neutral	4	deleterious	-5.87	deleterious	-4.43	high_impact	3.77	0.64	neutral	0.09	damaging	3.86	23.50	deleterious	0.04	0.35	NA	NA	0.84	disease	0.76	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.59	low_impact	-1.48	low_impact	2.6	high_impact	0.28	0.8	14.6	9.81	0.41	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11105	11105	A	G	MI.17045	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	346	116	I	V	Atc/Gtc	-2.24	0	0	benign	0.4	neutral	0.16	neutral	4.4	neutral	0.16	neutral	-0.62	low_impact	1.16	0.78	neutral	0.61	neutral	1.04	10.90	neutral	0.4	0.5	NA	NA	0.4	neutral	0.37	neutral	0.19	neutral	6	0.81	neutral	0.38	neutral	-6	neutral	0.15	neutral	-0.55	medium_impact	-0.2	medium_impact	0.02	medium_impact	0.62	0.8	11.76	8.95	0.36	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11105	11105	A	C	MI.17046	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	346	116	I	L	Atc/Ctc	-2.24	0	0	benign	0.18	neutral	0.93	neutral	4.71	neutral	1.17	neutral	-1.04	neutral_impact	0.42	0.72	neutral	0.69	neutral	0.69	8.76	deleterious	0.23	0.45	NA	NA	0.48	neutral	0.31	neutral	0.33	neutral	3	0.08	neutral	0.88	deleterious	-6	neutral	0.13	neutral	-0.1	medium_impact	0.83	medium_impact	-0.71	medium_impact	0.65	0.8	11.76	8.95	0.26	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11105	11105	A	T	MI.17047	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	346	116	I	F	Atc/Ttc	-2.24	0	0	possibly_damaging	0.83	neutral	0.63	neutral	4.46	neutral	1.01	neutral	-2.49	low_impact	1	0.68	neutral	0.51	neutral	1.78	14.85	neutral	0.18	0.45	NA	NA	0.6	disease	0.39	neutral	0.47	neutral	1	0.8	neutral	0.4	neutral	-3	neutral	0.34	neutral	-1.37	low_impact	0.33	medium_impact	-0.14	medium_impact	0.60	0.8	11.76	8.95	0.32	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11106	11106	T	C	MI.17048	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	347	116	I	T	aTc/aCc	4.44	0.99	0	possibly_damaging	0.81	neutral	0.2	neutral	4.32	neutral	-2.14	deleterious	-3.1	medium_impact	2.02	0.75	neutral	0.64	neutral	1.51	13.37	neutral	0.08	0.35	NA	NA	0.44	neutral	0.4	neutral	0.21	neutral	6	0.89	neutral	0.2	neutral	0	NA	0.24	neutral	-1.31	low_impact	-0.14	medium_impact	0.87	medium_impact	0.28	0.8	11.76	8.95	0.61	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	COSM1155503	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11106	11106	T	G	MI.17049	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	347	116	I	S	aTc/aGc	4.44	0.99	0	possibly_damaging	0.86	deleterious	0.04	neutral	4.31	neutral	-2.47	deleterious	-3.88	medium_impact	2.68	0.71	neutral	0.5	neutral	2.33	18.40	deleterious	0.03	0.35	NA	NA	0.77	disease	0.44	neutral	0.59	disease	2	0.98	neutral	0.09	neutral	4	deleterious	0.31	neutral	-1.46	low_impact	-0.57	medium_impact	1.53	medium_impact	0.24	0.8	11.76	8.95	0.57	P	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8489	8489	A	C	MI.1705	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	124	42	M	L	Ata/Cta	-6.35	0	0	possibly_damaging	0.66	neutral	0.79	neutral	1.26	neutral	-1.98	neutral	-0.46	neutral_impact	0.18	1	neutral	0.94	neutral	1.18	11.64	neutral	0.62618842	0.85	0.12	neutral	0.17	neutral	0.32	neutral	0.07	neutral	9	0.59	neutral	0.57	deleterious	-3	neutral	0.30	neutral	-1.03	low_impact	0.62	medium_impact	-0.94	medium_impact	0.53	0.85	17.65	9.06	0.36	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11106	11106	T	A	MI.17050	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	347	116	I	N	aTc/aAc	4.44	0.99	0	probably_damaging	0.95	deleterious	0	neutral	4.29	deleterious	-3.93	deleterious	-4.66	medium_impact	3.38	0.68	neutral	0.44	neutral	2.81	21.40	deleterious	0.08	0.35	NA	NA	0.81	disease	0.6	disease	0.74	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.50	deleterious	-1.92	low_impact	-1.48	low_impact	2.22	high_impact	0.31	0.8	11.76	8.95	0.54	P	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11107	11107	C	A	MI.17051	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	348	116	I	M	atC/atA	3.75	0.99	0	benign	0.39	neutral	0.4	neutral	4.34	neutral	-1.49	neutral	-1.49	neutral_impact	0.67	0.75	neutral	0.88	neutral	0.69	8.79	deleterious	0.26	0.45	NA	NA	0.31	neutral	0.31	neutral	0.18	neutral	6	0.54	neutral	0.51	deleterious	-6	neutral	0.12	neutral	-0.54	medium_impact	0.1	medium_impact	-0.46	medium_impact	0.51	0.8	11.76	8.95	0.49	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11107	11107	C	G	MI.17052	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	348	116	I	M	atC/atG	3.75	0.99	0	benign	0.39	neutral	0.4	neutral	4.34	neutral	-1.49	neutral	-1.49	neutral_impact	0.67	0.75	neutral	0.88	neutral	0.19	4.60	deleterious	0.26	0.45	NA	NA	0.31	neutral	0.31	neutral	0.18	neutral	6	0.54	neutral	0.51	deleterious	-6	neutral	0.12	neutral	-0.54	medium_impact	0.1	medium_impact	-0.46	medium_impact	0.51	0.8	11.76	8.95	0.49	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11108	11108	A	C	MI.17053	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	349	117	M	L	Ata/Cta	-7.78	0	0	benign	0	neutral	1	neutral	4.88	neutral	2.16	neutral	-0.24	neutral_impact	-0.18	0.78	neutral	0.99	neutral	0.98	10.53	neutral	0.23	0.45	NA	NA	0.34	neutral	0.42	neutral	0.17	neutral	7	0	neutral	1	deleterious	-6	neutral	0.51	deleterious	2.1	high_impact	1.88	high_impact	-1.3	low_impact	0.21	0.8	38.56	9.77	0.3	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11108	11108	A	T	MI.17054	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	349	117	M	L	Ata/Tta	-7.78	0	0	benign	0	neutral	1	neutral	4.88	neutral	2.16	neutral	-0.24	neutral_impact	-0.18	0.78	neutral	0.99	neutral	1.05	10.92	neutral	0.23	0.45	NA	NA	0.34	neutral	0.42	neutral	0.17	neutral	7	0	neutral	1	deleterious	-6	neutral	0.51	deleterious	2.1	high_impact	1.88	high_impact	-1.3	low_impact	0.21	0.8	38.56	9.77	0.3	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11108	11108	A	G	MI.17055	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	349	117	M	V	Ata/Gta	-7.78	0	0	benign	0.13	neutral	0.08	neutral	4.7	neutral	0.67	neutral	-1.76	low_impact	1.84	0.69	neutral	0.59	neutral	2.57	19.94	deleterious	0.2	0.45	NA	NA	0.77	disease	0.66	disease	0.7	disease	4	0.91	neutral	0.48	deleterious	-6	neutral	0.68	deleterious	0.06	medium_impact	-0.39	medium_impact	0.69	medium_impact	0.30	0.8	38.56	9.77	0.37	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11109	11109	T	A	MI.17056	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	350	117	M	K	aTa/aAa	-5.47	0	0	possibly_damaging	0.49	deleterious	0.04	neutral	4.62	neutral	-1.74	deleterious	-3.65	medium_impact	2.52	0.7	neutral	0.45	neutral	3.84	23.40	deleterious	0.04	0.35	NA	NA	0.9	disease	0.72	disease	0.8	disease	6	0.96	neutral	0.28	neutral	4	deleterious	0.84	deleterious	-0.7	medium_impact	-0.57	medium_impact	1.37	medium_impact	0.18	0.8	38.56	9.77	0.36	N	0.91	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11109	11109	T	C	MI.17057	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	350	117	M	T	aTa/aCa	-5.47	0	0	benign	0.41	neutral	0.05	neutral	4.75	neutral	0.88	deleterious	-3.22	medium_impact	2.02	0.67	neutral	0.65	neutral	2.85	21.60	deleterious	0.1	0.4	NA	NA	0.76	disease	0.61	disease	0.69	disease	4	0.94	neutral	0.32	neutral	-3	neutral	0.77	deleterious	-0.57	medium_impact	-0.52	medium_impact	0.87	medium_impact	0.19	0.8	38.56	9.77	0.35	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11110	11110	A	T	MI.17058	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	351	117	M	I	atA/atT	4.67	0.69	0	benign	0.08	neutral	0.14	neutral	4.71	neutral	-0.19	neutral	-1.34	low_impact	1.84	0.69	neutral	0.51	neutral	3.27	22.80	deleterious	0.24	0.45	NA	NA	0.8	disease	0.64	disease	0.7	disease	4	0.85	neutral	0.53	deleterious	-6	neutral	0.74	deleterious	0.28	medium_impact	-0.24	medium_impact	0.69	medium_impact	0.21	0.8	38.56	9.77	0.42	N	0.55	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11110	11110	A	C	MI.17059	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	351	117	M	I	atA/atC	4.67	0.69	0	benign	0.08	neutral	0.14	neutral	4.71	neutral	-0.19	neutral	-1.34	low_impact	1.84	0.69	neutral	0.51	neutral	3.18	22.70	deleterious	0.24	0.45	NA	NA	0.8	disease	0.64	disease	0.7	disease	4	0.85	neutral	0.53	deleterious	-6	neutral	0.74	deleterious	0.28	medium_impact	-0.24	medium_impact	0.69	medium_impact	0.21	0.8	38.56	9.77	0.41	N	0.55	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8490	8490	T	C	MI.1706	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	125	42	M	T	aTa/aCa	-9.59	0	0	possibly_damaging	0.88	neutral	0.75	neutral	1.2	deleterious	-3.05	neutral	-0.17	neutral_impact	-0.86	1	neutral	0.98	neutral	1.11	11.28	neutral	0.78924240	0.85	0.24	neutral	0.21	neutral	0.24	neutral	0.15	neutral	7	0.86	neutral	0.44	neutral	-3	neutral	0.53	deleterious	-1.58	low_impact	0.56	medium_impact	-1.83	low_impact	0.15	0.85	17.65	9.06	0.35	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11111	11111	T	G	MI.17060	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	352	118	F	V	Ttt/Gtt	-1.55	0	0	possibly_damaging	0.74	deleterious	0	neutral	4.54	neutral	-2.03	deleterious	-5.09	high_impact	4.12	0.63	neutral	0.63	neutral	3.85	23.40	deleterious	0.06	0.35	NA	NA	0.86	disease	0.66	disease	0.75	disease	5	1	deleterious	0.13	neutral	5	deleterious	0.82	deleterious	-1.14	low_impact	-1.48	low_impact	2.95	high_impact	0.34	0.8	45.32	8.57	0.47	N	0.96	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11111	11111	T	C	MI.17061	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	352	118	F	L	Ttt/Ctt	-1.55	0	0	benign	0.08	neutral	0.05	neutral	4.62	neutral	0.38	deleterious	-4.31	medium_impact	3.08	0.62	neutral	0.72	neutral	3.88	23.50	deleterious	0.14	0.4	NA	NA	0.81	disease	0.56	disease	0.63	disease	3	0.95	neutral	0.49	deleterious	-3	neutral	0.79	deleterious	0.28	medium_impact	-0.52	medium_impact	1.92	medium_impact	0.51	0.8	45.32	8.57	0.48	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11111	11111	T	A	MI.17062	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	352	118	F	I	Ttt/Att	-1.55	0	0	possibly_damaging	0.74	deleterious	0	neutral	4.68	neutral	-1.81	deleterious	-4.36	high_impact	4.12	0.65	neutral	0.66	neutral	4.24	23.90	deleterious	0.1	0.4	NA	NA	0.83	disease	0.64	disease	0.72	disease	4	1	deleterious	0.13	neutral	5	deleterious	0.82	deleterious	-1.14	low_impact	-1.48	low_impact	2.95	high_impact	0.47	0.8	45.32	8.57	0.53	P	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11112	11112	T	G	MI.17063	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	353	118	F	C	tTt/tGt	4.44	1	0	probably_damaging	0.98	deleterious	0	neutral	4.43	deleterious	-4.99	deleterious	-5.9	high_impact	4.47	0.68	neutral	0.53	neutral	4.01	23.60	deleterious	0.03	0.35	NA	NA	0.86	disease	0.68	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.31	low_impact	-1.48	low_impact	3.3	high_impact	0.19	0.8	45.32	8.57	0.58	P	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11112	11112	T	A	MI.17064	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	353	118	F	Y	tTt/tAt	4.44	1	0	possibly_damaging	0.89	deleterious	0	neutral	4.45	deleterious	-3.87	neutral	-2.03	high_impact	3.57	0.66	neutral	0.57	neutral	4.32	24.00	deleterious	0.12	0.4	NA	NA	0.78	disease	0.63	disease	0.7	disease	4	1	deleterious	0.06	neutral	5	deleterious	0.82	deleterious	-1.57	low_impact	-1.48	low_impact	2.41	high_impact	0.54	0.8	45.32	8.57	0.63	P	0.88	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11112	11112	T	C	MI.17065	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	353	118	F	S	tTt/tCt	4.44	1	0	probably_damaging	0.96	deleterious	0	neutral	4.46	deleterious	-3.51	deleterious	-5.92	high_impact	4.12	0.7	neutral	0.7	neutral	4.21	23.90	deleterious	0.02	0.35	NA	NA	0.84	disease	0.65	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-2.01	low_impact	-1.48	low_impact	2.95	high_impact	0.34	0.8	45.32	8.57	0.55	P	0.93	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11113	11113	T	A	MI.17066	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	354	118	F	L	ttT/ttA	5.6	1	0	benign	0.08	neutral	0.05	neutral	4.62	neutral	0.38	deleterious	-4.31	medium_impact	3.08	0.62	neutral	0.72	neutral	4.32	24.00	deleterious	0.14	0.4	NA	NA	0.81	disease	0.56	disease	0.63	disease	3	0.95	neutral	0.49	deleterious	-3	neutral	0.79	deleterious	0.28	medium_impact	-0.52	medium_impact	1.92	medium_impact	0.51	0.8	45.32	8.57	0.69	P	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11113	11113	T	G	MI.17067	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	354	118	F	L	ttT/ttG	5.6	1	0	benign	0.08	neutral	0.05	neutral	4.62	neutral	0.38	deleterious	-4.31	medium_impact	3.08	0.62	neutral	0.72	neutral	4.25	23.90	deleterious	0.14	0.4	NA	NA	0.81	disease	0.56	disease	0.63	disease	3	0.95	neutral	0.49	deleterious	-3	neutral	0.79	deleterious	0.28	medium_impact	-0.52	medium_impact	1.92	medium_impact	0.51	0.8	45.32	8.57	0.69	P	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11114	11114	T	C	MI.17068	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	355	119	Y	H	Tat/Cat	-7.09	0	0	probably_damaging	1	deleterious	0	neutral	4.21	deleterious	-5.78	deleterious	-3.83	high_impact	4.32	0.66	neutral	0.13	damaging	3.40	23.00	deleterious	0.07	0.35	NA	NA	0.82	disease	0.77	disease	0.77	disease	5	1	deleterious	0	deleterious	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.15	high_impact	0.18	0.8	46.41	8.92	0.47	N	0.97	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11114	11114	T	G	MI.17069	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	355	119	Y	D	Tat/Gat	-7.09	0	0	probably_damaging	1	deleterious	0	neutral	4.2	deleterious	-7.06	deleterious	-7.6	high_impact	4.32	0.74	neutral	0.15	damaging	3.80	23.40	deleterious	0.03	0.35	NA	NA	0.87	disease	0.76	disease	0.79	disease	6	1	deleterious	0	deleterious	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.15	high_impact	0.14	0.8	46.41	8.92	0.45	N	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8490	8490	T	A	MI.1707	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	125	42	M	K	aTa/aAa	-9.59	0	0	possibly_damaging	0.88	neutral	0.68	neutral	1.18	deleterious	-3.6	neutral	-1.95	neutral_impact	0.54	1	neutral	0.72	neutral	2.65	20.50	deleterious	0.46643282	0.85	0.47	neutral	0.37	neutral	0.32	neutral	0.16	neutral	7	0.86	neutral	0.4	neutral	-3	neutral	0.59	deleterious	-1.58	low_impact	0.48	medium_impact	-0.64	medium_impact	0.46	0.85	17.65	9.06	0.38	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11114	11114	T	A	MI.17070	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	355	119	Y	N	Tat/Aat	-7.09	0	0	probably_damaging	1	deleterious	0	neutral	4.21	deleterious	-5.57	deleterious	-6.86	high_impact	3.98	0.69	neutral	0.16	damaging	3.88	23.50	deleterious	0.04	0.35	NA	NA	0.86	disease	0.68	disease	0.75	disease	5	1	deleterious	0	deleterious	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.81	high_impact	0.13	0.8	46.41	8.92	0.33	N	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11115	11115	A	C	MI.17071	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	356	119	Y	S	tAt/tCt	7.44	1	0	probably_damaging	1	deleterious	0	neutral	4.22	deleterious	-5.01	deleterious	-6.83	high_impact	4.32	0.69	neutral	0.17	damaging	3.61	23.20	deleterious	0.04	0.35	NA	NA	0.84	disease	0.68	disease	0.75	disease	5	1	deleterious	0	deleterious	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.15	high_impact	0.13	0.8	46.41	8.92	0.55	P	0.95	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11115	11115	A	G	MI.17072	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	356	119	Y	C	tAt/tGt	7.44	1	0	probably_damaging	1	deleterious	0	neutral	4.23	deleterious	-6.34	deleterious	-6.83	high_impact	4.32	0.7	neutral	0.12	damaging	3.45	23.00	deleterious	0.03	0.35	NA	NA	0.87	disease	0.73	disease	0.78	disease	6	1	deleterious	0	deleterious	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.15	high_impact	0.16	0.8	46.41	8.92	0.54	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11115	11115	A	T	MI.17073	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	356	119	Y	F	tAt/tTt	7.44	1	0	probably_damaging	1	neutral	0.09	neutral	4.55	neutral	0.54	deleterious	-2.86	low_impact	1.51	0.7	neutral	0.33	neutral	3.25	22.80	deleterious	0.15	0.4	NA	NA	0.71	disease	0.48	neutral	0.49	neutral	0	1	deleterious	0.05	neutral	-2	neutral	0.83	deleterious	-3.54	low_impact	-0.36	medium_impact	0.37	medium_impact	0.42	0.8	46.41	8.92	0.59	P	0.79	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11117	11117	A	C	MI.17074	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	358	120	I	L	Atc/Ctc	-2.24	0	0	benign	0.39	neutral	0.25	neutral	4.69	neutral	0.04	neutral	-1.54	low_impact	1.9	0.72	neutral	0.51	neutral	1.72	14.52	neutral	0.17	0.45	NA	NA	0.58	disease	0.37	neutral	0.46	neutral	1	0.71	neutral	0.43	neutral	-6	neutral	0.18	neutral	-0.54	medium_impact	-0.07	medium_impact	0.75	medium_impact	0.52	0.8	46.19	9.15	0.4	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11117	11117	A	T	MI.17075	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	358	120	I	F	Atc/Ttc	-2.24	0	0	probably_damaging	0.93	neutral	0.27	neutral	4.44	neutral	-0.86	deleterious	-3.09	medium_impact	1.96	0.67	neutral	0.44	neutral	3.17	22.70	deleterious	0.07	0.35	NA	NA	0.79	disease	0.62	disease	0.57	disease	1	0.94	neutral	0.17	neutral	1	deleterious	0.62	deleterious	-1.77	low_impact	-0.04	medium_impact	0.81	medium_impact	0.46	0.8	46.19	9.15	0.34	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11117	11117	A	G	MI.17076	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	358	120	I	V	Atc/Gtc	-2.24	0	0	benign	0.05	neutral	0.35	neutral	4.51	neutral	1.14	neutral	-0.58	low_impact	1.88	0.77	neutral	0.88	neutral	-0.49	0.23	neutral	0.22	0.45	NA	NA	0.18	neutral	0.37	neutral	0.22	neutral	6	0.62	neutral	0.65	deleterious	-6	neutral	0.11	neutral	0.48	medium_impact	0.05	medium_impact	0.73	medium_impact	0.49	0.8	46.19	9.15	0.41	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11118	11118	T	A	MI.17077	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	359	120	I	N	aTc/aAc	0.75	0.22	0	probably_damaging	0.96	deleterious	0	neutral	4.34	deleterious	-4.59	deleterious	-5.31	high_impact	4.12	0.68	neutral	0.44	neutral	4.18	23.80	deleterious	0.03	0.35	NA	NA	0.86	disease	0.61	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.01	low_impact	-1.48	low_impact	2.95	high_impact	0.31	0.8	46.19	9.15	0.43	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11118	11118	T	G	MI.17078	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	359	120	I	S	aTc/aGc	0.75	0.22	0	probably_damaging	0.9	deleterious	0	neutral	4.36	deleterious	-3.31	deleterious	-4.54	high_impact	3.77	0.72	neutral	0.46	neutral	2.57	19.93	deleterious	0.02	0.35	NA	NA	0.85	disease	0.6	disease	0.74	disease	5	1	deleterious	0.05	neutral	6	deleterious	0.53	deleterious	-1.61	low_impact	-1.48	low_impact	2.6	high_impact	0.25	0.8	46.19	9.15	0.41	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11118	11118	T	C	MI.17079	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	359	120	I	T	aTc/aCc	0.75	0.22	0	possibly_damaging	0.75	deleterious	0	neutral	4.37	neutral	-2.76	deleterious	-3.67	medium_impact	3.43	0.76	neutral	0.56	neutral	1.50	13.30	neutral	0.03	0.35	NA	NA	0.7	disease	0.54	disease	0.59	disease	2	1	deleterious	0.13	neutral	4	deleterious	0.43	deleterious	-1.17	low_impact	-1.48	low_impact	2.27	high_impact	0.22	0.8	46.19	9.15	0.38	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8491	8491	A	T	MI.1708	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	126	42	M	I	atA/atT	-7.28	0	0	possibly_damaging	0.82	neutral	0.46	neutral	1.25	neutral	-2.15	neutral	-0.51	neutral_impact	-0.18	0.99	neutral	0.95	neutral	1.29	12.21	neutral	0.64626452	0.85	0.23	neutral	0.12	neutral	0.34	neutral	0.06	neutral	9	0.81	neutral	0.32	neutral	-3	neutral	0.44	deleterious	-1.38	low_impact	0.25	medium_impact	-1.25	low_impact	0.52	0.85	17.65	9.06	0.48	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11119	11119	C	G	MI.17080	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	360	120	I	M	atC/atG	4.67	0.76	0	probably_damaging	0.93	neutral	0.1	neutral	4.46	neutral	-2.38	neutral	-2.22	medium_impact	3.15	0.74	neutral	0.54	neutral	2.99	22.20	deleterious	0.08	0.35	NA	NA	0.63	disease	0.53	disease	0.54	disease	1	0.97	neutral	0.09	neutral	1	deleterious	0.58	deleterious	-1.77	low_impact	-0.33	medium_impact	1.99	medium_impact	0.38	0.8	46.19	9.15	0.49	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11119	11119	C	A	MI.17081	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	360	120	I	M	atC/atA	4.67	0.76	0	probably_damaging	0.93	neutral	0.1	neutral	4.46	neutral	-2.38	neutral	-2.22	medium_impact	3.15	0.74	neutral	0.54	neutral	3.40	23.00	deleterious	0.08	0.35	NA	NA	0.63	disease	0.53	disease	0.54	disease	1	0.97	neutral	0.09	neutral	1	deleterious	0.58	deleterious	-1.77	low_impact	-0.33	medium_impact	1.99	medium_impact	0.38	0.8	46.19	9.15	0.5	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11120	11120	T	G	MI.17082	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	361	121	F	V	Ttc/Gtc	-6.16	0	0	benign	0.05	deleterious	0.03	neutral	4.55	neutral	-2.96	neutral	0.62	medium_impact	2.78	0.76	neutral	0.69	neutral	2.05	16.54	deleterious	0.1	0.4	NA	NA	0.66	disease	0.5	neutral	0.51	disease	0	0.97	neutral	0.49	deleterious	1	deleterious	0.17	neutral	0.48	medium_impact	-0.64	medium_impact	1.62	medium_impact	0.29	0.8	46.62	10.39	0.43	N	0.17	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11120	11120	T	A	MI.17083	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	361	121	F	I	Ttc/Atc	-6.16	0	0	benign	0.03	neutral	0.06	neutral	4.53	deleterious	-3.36	neutral	1.08	medium_impact	2.44	0.74	neutral	0.6	neutral	2.36	18.56	deleterious	0.12	0.4	NA	NA	0.56	disease	0.48	neutral	0.5	neutral	0	0.94	neutral	0.52	deleterious	-3	neutral	0.17	neutral	0.7	medium_impact	-0.47	medium_impact	1.29	medium_impact	0.38	0.8	46.62	10.39	0.45	N	0.08	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11120	11120	T	C	MI.17084	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	361	121	F	L	Ttc/Ctc	-6.16	0	0	benign	0	neutral	0.48	neutral	4.58	neutral	-2.53	neutral	2.26	neutral_impact	-0.45	0.79	neutral	0.95	neutral	-0.28	0.74	neutral	0.13	0.4	NA	NA	0.35	neutral	0.34	neutral	0.14	neutral	7	0.52	neutral	0.74	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	0.18	medium_impact	-1.57	low_impact	0.55	0.8	46.62	10.39	0.28	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11121	11121	T	C	MI.17085	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	362	121	F	S	tTc/tCc	-4.32	0	0	benign	0.01	neutral	0.19	neutral	4.61	deleterious	-3.33	neutral	-1.28	neutral_impact	0.42	0.7	neutral	0.85	neutral	2.29	18.13	deleterious	0.03	0.35	NA	NA	0.42	neutral	0.44	neutral	0.16	neutral	7	0.81	neutral	0.59	deleterious	-6	neutral	0.28	neutral	1.16	medium_impact	-0.15	medium_impact	-0.71	medium_impact	0.25	0.8	46.62	10.39	0.43	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11121	11121	T	A	MI.17086	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	362	121	F	Y	tTc/tAc	-4.32	0	0	benign	0.26	neutral	0.14	neutral	4.5	deleterious	-4.57	neutral	-0.79	low_impact	1.34	0.75	neutral	0.65	neutral	2.33	18.33	deleterious	0.16	0.45	NA	NA	0.5	neutral	0.55	disease	0.66	disease	3	0.83	neutral	0.44	neutral	-6	neutral	0.26	neutral	-0.29	medium_impact	-0.24	medium_impact	0.2	medium_impact	0.53	0.8	46.62	10.39	0.41	N	0.26	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11121	11121	T	G	MI.17087	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	362	121	F	C	tTc/tGc	-4.32	0	0	possibly_damaging	0.76	deleterious	0.04	neutral	4.47	deleterious	-4.55	neutral	-0.86	low_impact	1.63	0.71	neutral	0.46	neutral	3.70	23.30	deleterious	0.04	0.35	NA	NA	0.71	disease	0.53	disease	0.63	disease	3	0.97	neutral	0.14	neutral	1	deleterious	0.59	deleterious	-1.19	low_impact	-0.57	medium_impact	0.49	medium_impact	0.19	0.8	46.62	10.39	0.38	N	0.47	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11122	11122	C	A	MI.17088	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	363	121	F	L	ttC/ttA	2.14	0.48	0	benign	0	neutral	0.48	neutral	4.58	neutral	-2.53	neutral	2.26	neutral_impact	-0.45	0.79	neutral	0.95	neutral	0.33	5.95	deleterious	0.13	0.4	NA	NA	0.35	neutral	0.34	neutral	0.14	neutral	7	0.52	neutral	0.74	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	0.18	medium_impact	-1.57	low_impact	0.55	0.8	46.62	10.39	0.31	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11122	11122	C	G	MI.17089	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	363	121	F	L	ttC/ttG	2.14	0.48	0	benign	0	neutral	0.48	neutral	4.58	neutral	-2.53	neutral	2.26	neutral_impact	-0.45	0.79	neutral	0.95	neutral	0.03	2.84	deleterious	0.13	0.4	NA	NA	0.35	neutral	0.34	neutral	0.14	neutral	7	0.52	neutral	0.74	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	0.18	medium_impact	-1.57	low_impact	0.55	0.8	46.62	10.39	0.31	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8491	8491	A	C	MI.1709	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	126	42	M	I	atA/atC	-7.28	0	0	possibly_damaging	0.82	neutral	0.46	neutral	1.25	neutral	-2.15	neutral	-0.51	neutral_impact	-0.18	0.99	neutral	0.95	neutral	1.21	11.82	neutral	0.64626452	0.85	0.23	neutral	0.12	neutral	0.34	neutral	0.06	neutral	9	0.81	neutral	0.32	neutral	-3	neutral	0.44	deleterious	-1.38	low_impact	0.25	medium_impact	-1.25	low_impact	0.52	0.85	17.65	9.06	0.49	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11123	11123	T	C	MI.17090	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	364	122	F	L	Ttc/Ctc	0.29	0.47	0	probably_damaging	1	deleterious	0	neutral	4.71	neutral	-0.1	deleterious	-4.64	high_impact	4.42	0.61	neutral	0.16	damaging	3.88	23.50	deleterious	0.1	0.4	NA	NA	0.82	disease	0.59	disease	0.7	disease	4	1	deleterious	0	deleterious	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.48	0.8	45.97	8.86	0.47	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11123	11123	T	A	MI.17091	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	364	122	F	I	Ttc/Atc	0.29	0.47	0	probably_damaging	1	deleterious	0	neutral	4.64	neutral	-1.34	deleterious	-4.64	high_impact	4.42	0.63	neutral	0.18	damaging	4.22	23.90	deleterious	0.09	0.35	NA	NA	0.83	disease	0.66	disease	0.73	disease	5	1	deleterious	0	deleterious	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.33	0.8	45.97	8.86	0.48	N	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11123	11123	T	G	MI.17092	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	364	122	F	V	Ttc/Gtc	0.29	0.47	0	probably_damaging	1	deleterious	0	neutral	4.51	neutral	-1.59	deleterious	-5.41	high_impact	4.42	0.62	neutral	0.17	damaging	3.92	23.50	deleterious	0.08	0.35	NA	NA	0.86	disease	0.69	disease	0.76	disease	5	1	deleterious	0	deleterious	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.23	0.8	45.97	8.86	0.46	N	0.96	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11124	11124	T	A	MI.17093	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	365	122	F	Y	tTc/tAc	5.83	1	0	probably_damaging	1	neutral	0.1	neutral	4.51	neutral	-1.66	neutral	-2.32	medium_impact	2.77	0.63	neutral	0.17	damaging	4.19	23.90	deleterious	0.11	0.4	NA	NA	0.77	disease	0.63	disease	0.69	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.33	medium_impact	1.61	medium_impact	0.54	0.8	45.97	8.86	0.63	P	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11124	11124	T	C	MI.17094	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	365	122	F	S	tTc/tCc	5.83	1	0	probably_damaging	1	deleterious	0	neutral	4.46	neutral	-2.81	deleterious	-6.18	high_impact	4.42	0.66	neutral	0.2	damaging	4.18	23.80	deleterious	0.04	0.35	NA	NA	0.84	disease	0.66	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.27	0.8	45.97	8.86	0.59	P	0.93	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11124	11124	T	G	MI.17095	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	365	122	F	C	tTc/tGc	5.83	1	0	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-4.46	deleterious	-6.18	high_impact	4.42	0.64	neutral	0.15	damaging	4.03	23.60	deleterious	0.04	0.35	NA	NA	0.84	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.20	0.8	45.97	8.86	0.57	P	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11125	11125	C	A	MI.17096	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	366	122	F	L	ttC/ttA	5.83	1	0	probably_damaging	1	deleterious	0	neutral	4.71	neutral	-0.1	deleterious	-4.64	high_impact	4.42	0.61	neutral	0.16	damaging	4.52	24.30	deleterious	0.1	0.4	NA	NA	0.82	disease	0.59	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.48	0.8	45.97	8.86	0.6	P	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11125	11125	C	G	MI.17097	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	366	122	F	L	ttC/ttG	5.83	1	0	probably_damaging	1	deleterious	0	neutral	4.71	neutral	-0.1	deleterious	-4.64	high_impact	4.42	0.61	neutral	0.16	damaging	4.24	23.90	deleterious	0.1	0.4	NA	NA	0.82	disease	0.59	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.48	0.8	45.97	8.86	0.6	P	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11126	11126	G	A	MI.17098	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	367	123	E	K	Gaa/Aaa	-2.24	0	0	probably_damaging	1	deleterious	0	neutral	3.14	deleterious	-6.47	deleterious	-3.1	high_impact	4.5	0.34	damaging	0.06	damaging	4.41	24.10	deleterious	0.03	0.35	NA	NA	0.88	disease	0.84	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.67	0.85	47.06	9.35	0.63	P	1.00	polymorphism	1	0.43	.	.	.	.	.	papillary thyroid carcinoma	COSM1138226	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11126	11126	G	C	MI.17099	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	367	123	E	Q	Gaa/Caa	-2.24	0	0	probably_damaging	1	deleterious	0	neutral	3.14	deleterious	-6.46	neutral	-2.32	high_impact	4.5	0.36	damaging	0.08	damaging	3.24	22.80	deleterious	0.06	0.35	NA	NA	0.73	disease	0.78	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.36	0.8	47.06	9.35	0.6	P	0.92	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8605	8605	C	A	MI.171	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	79	27	P	T	Ccc/Acc	-6.58	0	0	probably_damaging	1	neutral	0.43	neutral	4.41	neutral	0.3	deleterious	-7.04	medium_impact	2.54	0.72	neutral	0.52	neutral	3.48	23.10	deleterious	0.32	0.65	0.49	neutral	0.69	disease	0.45	neutral	0.51	disease	0	1	deleterious	0.22	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.22	medium_impact	1.08	medium_impact	0.51	0.9	48.23	8.81	0.28	N	0.94	polymorphism	0.76	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8492	8492	A	C	MI.1710	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	127	43	K	Q	Aaa/Caa	-3.57	0	0	probably_damaging	0.99	neutral	0.48	neutral	1.54	neutral	-0.88	neutral	-2.48	medium_impact	2.61	0.98	neutral	0.51	neutral	3.37	22.90	deleterious	0.68836831	0.85	0.4	neutral	0.24	neutral	0.45	neutral	0.1	neutral	8	0.99	deleterious	0.25	neutral	1	deleterious	0.69	deleterious	-2.65	low_impact	0.27	medium_impact	1.14	medium_impact	0.66	0.85	4.41	8.93	0.44	N	0.62	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11127	11127	A	T	MI.17100	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	368	123	E	V	gAa/gTa	6.06	1	0	probably_damaging	1	deleterious	0	neutral	3.12	deleterious	-8.28	deleterious	-5.42	high_impact	4.5	0.35	damaging	0.09	damaging	4.20	23.90	deleterious	0.02	0.35	NA	NA	0.88	disease	0.78	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.13	0.8	47.06	9.35	0.73	P	0.80	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11127	11127	A	C	MI.17101	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	368	123	E	A	gAa/gCa	6.06	1	0	probably_damaging	1	deleterious	0	neutral	3.14	deleterious	-6.58	deleterious	-4.64	high_impact	4.14	0.4	damaging	0.14	damaging	3.67	23.20	deleterious	0.03	0.35	NA	NA	0.69	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.97	high_impact	0.21	0.8	47.06	9.35	0.78	P	0.74	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11127	11127	A	G	MI.17102	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	368	123	E	G	gAa/gGa	6.06	1	0	probably_damaging	1	deleterious	0	neutral	3.18	deleterious	-5.24	deleterious	-5.42	high_impact	4.5	0.36	damaging	0.13	damaging	4.22	23.90	deleterious	0.03	0.35	NA	NA	0.81	disease	0.77	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.08	0.8	47.06	9.35	0.8	P	0.53	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11128	11128	A	C	MI.17103	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	369	123	E	D	gaA/gaC	8.59	1	0	probably_damaging	1	deleterious	0	neutral	3.28	deleterious	-3.93	neutral	-2.32	high_impact	3.94	0.34	damaging	0.08	damaging	3.62	23.20	deleterious	0.07	0.35	NA	NA	0.73	disease	0.78	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	2.77	high_impact	0.31	0.8	47.06	9.35	0.79	P	0.89	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11128	11128	A	T	MI.17104	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	369	123	E	D	gaA/gaT	8.59	1	0	probably_damaging	1	deleterious	0	neutral	3.28	deleterious	-3.93	neutral	-2.32	high_impact	3.94	0.34	damaging	0.08	damaging	3.71	23.30	deleterious	0.07	0.35	NA	NA	0.73	disease	0.78	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	2.77	high_impact	0.31	0.8	47.06	9.35	0.79	P	0.89	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11129	11129	A	G	MI.17105	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	370	124	T	A	Acc/Gcc	2.83	1	0	benign	0.02	neutral	1	neutral	4.7	neutral	1.22	neutral	1.01	neutral_impact	-0.92	0.72	neutral	0.99	neutral	-1.37	0.00	neutral	0.26	0.45	NA	NA	0.07	neutral	0.17	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.09	neutral	0.87	medium_impact	1.88	high_impact	-2.04	low_impact	0.28	0.8	25.71	24.71	0.47	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11129	11129	A	C	MI.17106	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	370	124	T	P	Acc/Ccc	2.83	1	0	possibly_damaging	0.8	deleterious	0.02	neutral	4.58	neutral	-2.7	neutral	-1.86	medium_impact	2.69	0.66	neutral	0.46	neutral	1.66	14.18	neutral	0.04	0.35	NA	NA	0.91	disease	0.65	disease	0.82	disease	6	0.99	deleterious	0.11	neutral	4	deleterious	0.56	deleterious	-1.28	low_impact	-0.75	medium_impact	1.54	medium_impact	0.39	0.8	25.71	24.71	0.51	P	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11129	11129	A	T	MI.17107	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	370	124	T	S	Acc/Tcc	2.83	1	0	benign	0.35	neutral	0.5	neutral	4.63	neutral	-0.58	neutral	-0.19	neutral_impact	0.42	0.66	neutral	0.98	neutral	1.18	11.67	neutral	0.34	0.5	NA	NA	0.42	neutral	0.21	neutral	0.18	neutral	7	0.42	neutral	0.58	deleterious	-6	neutral	0.21	neutral	-0.47	medium_impact	0.2	medium_impact	-0.71	medium_impact	0.63	0.8	25.71	24.71	0.56	P	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11130	11130	C	G	MI.17108	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	371	124	T	S	aCc/aGc	0.29	0.98	0	benign	0.35	neutral	0.5	neutral	4.63	neutral	-0.58	neutral	-0.19	neutral_impact	0.42	0.66	neutral	0.98	neutral	1.50	13.33	neutral	0.34	0.5	NA	NA	0.42	neutral	0.21	neutral	0.18	neutral	7	0.42	neutral	0.58	deleterious	-6	neutral	0.21	neutral	-0.47	medium_impact	0.2	medium_impact	-0.71	medium_impact	0.63	0.8	25.71	24.71	0.52	P	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11130	11130	C	A	MI.17109	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	371	124	T	N	aCc/aAc	0.29	0.98	0	possibly_damaging	0.74	deleterious	0.03	neutral	4.59	neutral	-2.59	neutral	-2.08	medium_impact	2.34	0.69	neutral	0.62	neutral	1.96	15.93	deleterious	0.26	0.45	NA	NA	0.82	disease	0.51	disease	0.73	disease	5	0.98	neutral	0.15	neutral	4	deleterious	0.43	deleterious	-1.14	low_impact	-0.64	medium_impact	1.19	medium_impact	0.52	0.8	25.71	24.71	0.5	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8492	8492	A	G	MI.1711	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	127	43	K	E	Aaa/Gaa	-3.57	0	0	probably_damaging	0.97	neutral	0.84	neutral	1.55	neutral	-0.63	neutral	-2.45	low_impact	1.75	0.99	neutral	0.69	neutral	2.92	21.90	deleterious	0.42878708	0.85	0.35	neutral	0.24	neutral	0.43	neutral	0.1	neutral	8	0.97	neutral	0.44	neutral	-2	neutral	0.71	deleterious	-2.19	low_impact	0.7	medium_impact	0.4	medium_impact	0.52	0.85	4.41	8.93	0.35	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11130	11130	C	T	MI.17110	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	371	124	T	I	aCc/aTc	0.29	0.98	0	possibly_damaging	0.6	neutral	0.18	neutral	4.68	neutral	1.41	neutral	-1.88	low_impact	0.96	0.73	neutral	0.73	neutral	1.97	16.01	deleterious	0.11	0.4	NA	NA	0.81	disease	0.52	disease	0.57	disease	1	0.82	neutral	0.29	neutral	-3	neutral	0.36	neutral	-0.88	medium_impact	-0.17	medium_impact	-0.18	medium_impact	0.57	0.8	25.71	24.71	0.49	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11132	11132	A	G	MI.17111	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	373	125	T	A	Aca/Gca	-10.55	0	0	probably_damaging	1	deleterious	0.01	neutral	4.63	neutral	-0.86	deleterious	-3.87	medium_impact	2.36	0.68	neutral	0.58	neutral	3.42	23.00	deleterious	0.26	0.45	NA	NA	0.62	disease	0.64	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	1.21	medium_impact	0.33	0.8	47.93	9.47	0.4	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11132	11132	A	C	MI.17112	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	373	125	T	P	Aca/Cca	-10.55	0	0	probably_damaging	1	deleterious	0	neutral	4.57	deleterious	-4.31	deleterious	-4.64	medium_impact	3.37	0.7	neutral	0.5	neutral	3.41	23.00	deleterious	0.04	0.35	NA	NA	0.87	disease	0.76	disease	0.8	disease	6	1	deleterious	0	neutral	5	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.21	high_impact	0.36	0.8	47.93	9.47	0.4	N	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11132	11132	A	T	MI.17113	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	373	125	T	S	Aca/Tca	-10.55	0	0	probably_damaging	1	neutral	1	neutral	4.66	neutral	-1.33	deleterious	-3.09	low_impact	0.96	0.65	neutral	0.72	neutral	3.29	22.80	deleterious	0.36	0.5	NA	NA	0.35	neutral	0.35	neutral	0.16	neutral	7	1	deleterious	0.5	deleterious	-2	neutral	0.76	deleterious	-3.54	low_impact	1.88	high_impact	-0.18	medium_impact	0.62	0.8	47.93	9.47	0.33	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11133	11133	C	A	MI.17114	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	374	125	T	K	aCa/aAa	6.75	1	0	probably_damaging	1	deleterious	0	neutral	4.6	deleterious	-3.53	deleterious	-4.64	medium_impact	3.37	0.67	neutral	0.41	neutral	4.35	24.10	deleterious	0.07	0.35	NA	NA	0.89	disease	0.76	disease	0.81	disease	6	1	deleterious	0	deleterious	5	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.21	high_impact	0.34	0.8	47.93	9.47	0.56	P	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11133	11133	C	T	MI.17115	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	374	125	T	M	aCa/aTa	6.75	1	0	probably_damaging	1	deleterious	0	neutral	4.61	neutral	0.51	deleterious	-4.64	medium_impact	2.1	0.68	neutral	0.56	neutral	3.97	23.60	deleterious	0.14	0.4	NA	NA	0.81	disease	0.66	disease	0.71	disease	4	1	deleterious	0	deleterious	5	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	0.95	medium_impact	0.46	0.8	47.93	9.47	0.54	P	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11135	11135	C	G	MI.17116	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	376	126	L	V	Ctt/Gtt	-10.32	0	0	probably_damaging	1	deleterious	0.01	neutral	4.46	neutral	-2.53	neutral	-2.32	medium_impact	3.1	0.55	damaging	0.15	damaging	3.41	23.00	deleterious	0.26	0.45	NA	NA	0.64	disease	0.65	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-3.54	low_impact	-0.92	medium_impact	1.94	medium_impact	0.45	0.8	46.62	9.31	0.3	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11135	11135	C	T	MI.17117	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	376	126	L	F	Ctt/Ttt	-10.32	0	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-4.1	deleterious	-3.09	high_impact	3.87	0.53	damaging	0.13	damaging	3.89	23.50	deleterious	0.12	0.4	NA	NA	0.72	disease	0.67	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.7	high_impact	0.38	0.8	46.62	9.31	0.33	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11135	11135	C	A	MI.17118	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	376	126	L	I	Ctt/Att	-10.32	0	0	probably_damaging	1	neutral	0.08	neutral	4.45	neutral	-2.86	neutral	-1.55	medium_impact	2.73	0.55	damaging	0.17	damaging	4.08	23.70	deleterious	0.26	0.45	NA	NA	0.65	disease	0.5	neutral	0.51	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.39	medium_impact	1.58	medium_impact	0.45	0.8	46.62	9.31	0.35	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11136	11136	T	A	MI.17119	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	377	126	L	H	cTt/cAt	-0.4	0	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-5.11	deleterious	-5.42	high_impact	4.42	0.53	damaging	0.12	damaging	4.14	23.80	deleterious	0.04	0.35	NA	NA	0.79	disease	0.74	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.13	0.8	46.62	9.31	0.45	N	0.96	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8493	8493	A	T	MI.1712	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	128	43	K	M	aAa/aTa	-0.8	0	0	probably_damaging	1	neutral	0.11	neutral	1.5	neutral	-2.39	deleterious	-3.86	low_impact	1.72	0.99	neutral	0.78	neutral	3.71	23.30	deleterious	0.42878708	0.85	0.68	disease	0.15	neutral	0.39	neutral	0.11	neutral	8	1	deleterious	0.06	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	-0.22	medium_impact	0.38	medium_impact	0.47	0.85	4.41	8.93	0.59	P	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11136	11136	T	G	MI.17120	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	377	126	L	R	cTt/cGt	-0.4	0	0	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-4.35	deleterious	-4.64	high_impact	4.42	0.56	damaging	0.12	damaging	4.09	23.70	deleterious	0.02	0.35	NA	NA	0.89	disease	0.77	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.09	0.8	46.62	9.31	0.54	N	1.00	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11136	11136	T	C	MI.17121	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	377	126	L	P	cTt/cCt	-0.4	0	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-4.69	deleterious	-5.42	high_impact	3.87	0.53	damaging	0.13	damaging	3.86	23.50	deleterious	0.02	0.35	NA	NA	0.78	disease	0.72	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	2.7	high_impact	0.08	0.8	46.62	9.31	0.37	N	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11138	11138	A	G	MI.17122	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	379	127	I	V	Atc/Gtc	-4.09	0	0	benign	0.08	neutral	0.1	neutral	4.61	neutral	-1.02	neutral	-0.62	low_impact	1.32	0.81	neutral	0.98	neutral	1.76	14.78	neutral	0.44	0.55	NA	NA	0.36	neutral	0.37	neutral	0.16	neutral	7	0.89	neutral	0.51	deleterious	-6	neutral	0.66	deleterious	0.28	medium_impact	-0.33	medium_impact	0.18	medium_impact	0.46	0.8	15.25	12.4	0.45	N	0.16	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11138	11138	A	C	MI.17123	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	379	127	I	L	Atc/Ctc	-4.09	0	0	possibly_damaging	0.52	neutral	0.25	neutral	4.84	neutral	0.58	neutral	-1.45	low_impact	1.51	0.77	neutral	0.89	neutral	3.68	23.30	deleterious	0.24	0.45	NA	NA	0.69	disease	0.31	neutral	0.48	neutral	1	0.73	neutral	0.37	neutral	-3	neutral	0.71	deleterious	-0.75	medium_impact	-0.07	medium_impact	0.37	medium_impact	0.59	0.8	15.25	12.4	0.39	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11138	11138	A	T	MI.17124	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	379	127	I	F	Atc/Ttc	-4.09	0	0	probably_damaging	0.96	neutral	0.14	neutral	4.54	neutral	-2.59	deleterious	-3.04	medium_impact	2.67	0.65	neutral	0.51	neutral	3.73	23.30	deleterious	0.09	0.4	NA	NA	0.86	disease	0.67	disease	0.75	disease	5	0.98	neutral	0.09	neutral	1	deleterious	0.82	deleterious	-2.01	low_impact	-0.24	medium_impact	1.52	medium_impact	0.42	0.8	15.25	12.4	0.37	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11139	11139	T	A	MI.17125	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	380	127	I	N	aTc/aAc	3.06	0.99	0	probably_damaging	0.98	deleterious	0	neutral	4.44	deleterious	-5.13	deleterious	-5.29	high_impact	4.08	0.64	neutral	0.49	neutral	4.31	24.00	deleterious	0.07	0.35	NA	NA	0.89	disease	0.67	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.31	low_impact	-1.48	low_impact	2.91	high_impact	0.17	0.8	15.25	12.4	0.53	P	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11139	11139	T	G	MI.17126	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	380	127	I	S	aTc/aGc	3.06	0.99	0	probably_damaging	0.94	deleterious	0.01	neutral	4.47	deleterious	-3.61	deleterious	-4.51	high_impact	4.08	0.64	neutral	0.55	neutral	4.15	23.80	deleterious	0.04	0.35	NA	NA	0.87	disease	0.66	disease	0.75	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.84	deleterious	-1.84	low_impact	-0.92	medium_impact	2.91	high_impact	0.11	0.8	15.25	12.4	0.56	P	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11139	11139	T	C	MI.17127	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	380	127	I	T	aTc/aCc	3.06	0.99	0	possibly_damaging	0.83	deleterious	0	neutral	4.52	deleterious	-3.33	deleterious	-3.67	high_impact	3.54	0.62	neutral	0.46	neutral	3.32	22.90	deleterious	0.08	0.35	NA	NA	0.76	disease	0.64	disease	0.67	disease	3	1	deleterious	0.09	neutral	5	deleterious	0.80	deleterious	-1.37	low_impact	-1.48	low_impact	2.38	high_impact	0.15	0.8	15.25	12.4	0.55	P	0.96	polymorphism	1	0.33	.	.	.	.	.	.	COSM1138227	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11140	11140	C	G	MI.17128	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	381	127	I	M	atC/atG	4.67	0.99	0	probably_damaging	0.96	deleterious	0.01	neutral	4.51	neutral	-2.89	neutral	-2.17	medium_impact	3.19	0.72	neutral	0.78	neutral	3.34	22.90	deleterious	0.13	0.4	NA	NA	0.7	disease	0.65	disease	0.67	disease	3	1	deleterious	0.03	neutral	5	deleterious	0.75	deleterious	-2.01	low_impact	-0.92	medium_impact	2.03	high_impact	0.46	0.8	15.25	12.4	0.57	P	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11140	11140	C	A	MI.17129	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	381	127	I	M	atC/atA	4.67	0.99	0	probably_damaging	0.96	deleterious	0.01	neutral	4.51	neutral	-2.89	neutral	-2.17	medium_impact	3.19	0.72	neutral	0.78	neutral	3.78	23.40	deleterious	0.13	0.4	NA	NA	0.7	disease	0.65	disease	0.67	disease	3	1	deleterious	0.03	neutral	5	deleterious	0.75	deleterious	-2.01	low_impact	-0.92	medium_impact	2.03	high_impact	0.46	0.8	15.25	12.4	0.57	P	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8493	8493	A	C	MI.1713	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	128	43	K	T	aAa/aCa	-0.8	0	0	probably_damaging	0.98	neutral	0.53	neutral	2.01	neutral	2.54	deleterious	-3.11	low_impact	1.27	1	neutral	0.93	neutral	2.22	17.61	deleterious	0.47385093	0.85	0.27	neutral	0.2	neutral	0.34	neutral	0.08	neutral	8	0.98	deleterious	0.28	neutral	-2	neutral	0.68	deleterious	-2.36	low_impact	0.32	medium_impact	-0.01	medium_impact	0.50	0.85	4.41	8.93	0.42	N	0.10	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11141	11141	C	A	MI.17130	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	382	128	P	T	Ccc/Acc	-2.24	0	0	probably_damaging	1	deleterious	0	neutral	4.57	neutral	-2.06	deleterious	-6.19	high_impact	4.47	0.54	damaging	0.08	damaging	3.62	23.20	deleterious	0.11	0.4	NA	NA	0.82	disease	0.71	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.3	high_impact	0.49	0.8	47.06	9.38	0.4	N	0.89	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11141	11141	C	G	MI.17131	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	382	128	P	A	Ccc/Gcc	-2.24	0	0	probably_damaging	1	deleterious	0	neutral	4.58	neutral	0.2	deleterious	-6.19	high_impact	4.47	0.51	damaging	0.11	damaging	3.04	22.40	deleterious	0.14	0.4	NA	NA	0.72	disease	0.69	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.3	high_impact	0.68	0.85	47.06	9.38	0.44	N	0.77	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11141	11141	C	T	MI.17132	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	382	128	P	S	Ccc/Tcc	-2.24	0	0	probably_damaging	1	deleterious	0	neutral	4.6	neutral	-0.27	deleterious	-6.19	high_impact	4.13	0.51	damaging	0.1	damaging	3.83	23.40	deleterious	0.17	0.45	NA	NA	0.84	disease	0.69	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.96	high_impact	0.13	0.8	47.06	9.38	0.39	N	0.71	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11142	11142	C	T	MI.17133	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	383	128	P	L	cCc/cTc	4.44	0.99	0	probably_damaging	1	deleterious	0.04	neutral	4.63	neutral	-1.82	deleterious	-7.74	medium_impact	3.27	0.51	damaging	0.07	damaging	4.36	24.10	deleterious	0.09	0.35	NA	NA	0.91	disease	0.69	disease	0.76	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.87	deleterious	-3.54	low_impact	-0.57	medium_impact	2.11	high_impact	0.62	0.8	47.06	9.38	0.53	P	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11142	11142	C	G	MI.17134	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	383	128	P	R	cCc/cGc	4.44	0.99	0	probably_damaging	1	deleterious	0	neutral	4.49	deleterious	-4.08	deleterious	-6.96	high_impact	4.47	0.59	damaging	0.08	damaging	3.53	23.10	deleterious	0.05	0.35	NA	NA	0.92	disease	0.81	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.3	high_impact	0.33	0.8	47.06	9.38	0.64	P	0.58	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11142	11142	C	A	MI.17135	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	383	128	P	H	cCc/cAc	4.44	0.99	0	probably_damaging	1	deleterious	0	neutral	4.48	deleterious	-4.72	deleterious	-6.96	high_impact	4.47	0.54	damaging	0.07	damaging	3.98	23.60	deleterious	0.08	0.35	NA	NA	0.87	disease	0.8	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.3	high_impact	0.27	0.8	47.06	9.38	0.63	P	0.70	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11144	11144	A	C	MI.17136	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	385	129	T	P	Acc/Ccc	-12.62	0	0	probably_damaging	1	deleterious	0	neutral	4.51	deleterious	-3.52	deleterious	-4.63	high_impact	4.1	0.65	neutral	0.48	neutral	3.97	23.60	deleterious	0.03	0.35	NA	NA	0.85	disease	0.74	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.93	high_impact	0.33	0.8	47.06	9.2	0.43	N	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11144	11144	A	T	MI.17137	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	385	129	T	S	Acc/Tcc	-12.62	0	0	probably_damaging	1	deleterious	0	neutral	4.84	neutral	2.24	deleterious	-3.08	high_impact	3.55	0.59	damaging	0.61	neutral	3.80	23.40	deleterious	0.36	0.5	NA	NA	0.75	disease	0.63	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.39	high_impact	0.68	0.85	47.06	9.2	0.46	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11144	11144	A	G	MI.17138	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	385	129	T	A	Acc/Gcc	-12.62	0	0	probably_damaging	1	deleterious	0.01	neutral	4.61	neutral	-0.47	deleterious	-3.86	medium_impact	2.86	0.59	damaging	0.75	neutral	3.97	23.60	deleterious	0.21	0.45	NA	NA	0.69	disease	0.54	disease	0.61	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	1.7	medium_impact	0.31	0.8	47.06	9.2	0.41	N	0.69	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11145	11145	C	A	MI.17139	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	386	129	T	N	aCc/aAc	6.75	1	0	probably_damaging	1	deleterious	0	neutral	4.52	deleterious	-3.3	deleterious	-3.86	high_impact	4.1	0.6	neutral	0.52	neutral	3.64	23.20	deleterious	0.19	0.45	NA	NA	0.85	disease	0.65	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.93	high_impact	0.59	0.8	47.06	9.2	0.6	P	0.93	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8494	8494	A	C	MI.1714	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	129	43	K	N	aaA/aaC	0.13	0	0	probably_damaging	0.99	neutral	0.44	neutral	1.53	neutral	-1.12	neutral	-2.44	low_impact	1.55	1	neutral	0.84	neutral	1.69	14.34	neutral	0.76472473	0.85	0.45	neutral	0.08	neutral	0.36	neutral	0.04	neutral	9	0.99	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-2.65	low_impact	0.23	medium_impact	0.23	medium_impact	0.66	0.85	4.41	8.93	0.47	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11145	11145	C	G	MI.17140	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	386	129	T	S	aCc/aGc	6.75	1	0	probably_damaging	1	deleterious	0	neutral	4.84	neutral	2.24	deleterious	-3.08	high_impact	3.55	0.59	damaging	0.61	neutral	3.46	23.00	deleterious	0.36	0.5	NA	NA	0.75	disease	0.63	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.39	high_impact	0.68	0.85	47.06	9.2	0.61	P	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11145	11145	C	T	MI.17141	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	386	129	T	I	aCc/aTc	6.75	1	0	probably_damaging	1	neutral	0.31	neutral	4.62	neutral	-1.02	deleterious	-4.64	low_impact	1.84	0.61	neutral	0.61	neutral	3.95	23.60	deleterious	0.1	0.4	NA	NA	0.87	disease	0.53	disease	0.67	disease	3	1	deleterious	0.16	neutral	-2	neutral	0.86	deleterious	-3.54	low_impact	0.01	medium_impact	0.69	medium_impact	0.54	0.8	47.06	9.2	0.56	P	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11147	11147	T	A	MI.17142	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	388	130	L	M	Ttg/Atg	-11.01	0	0	probably_damaging	1	neutral	0.06	neutral	4.37	neutral	-2.07	neutral	-1.5	low_impact	1.8	0.71	neutral	0.72	neutral	3.51	23.10	deleterious	0.26	0.45	NA	NA	0.45	neutral	0.21	neutral	0.24	neutral	5	1	deleterious	0.03	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	-0.47	medium_impact	0.66	medium_impact	0.64	0.8	45.53	8.78	0.47	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11147	11147	T	G	MI.17143	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	388	130	L	V	Ttg/Gtg	-11.01	0	0	probably_damaging	1	deleterious	0.04	neutral	4.47	neutral	-0.42	neutral	-2.3	medium_impact	2.53	0.61	neutral	0.13	damaging	3.36	22.90	deleterious	0.23	0.45	NA	NA	0.6	disease	0.57	disease	0.65	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-0.57	medium_impact	1.38	medium_impact	0.61	0.8	45.53	8.78	0.32	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11148	11148	T	G	MI.17144	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	389	130	L	W	tTg/tGg	-0.17	0	0	probably_damaging	1	deleterious	0	neutral	4.34	neutral	-2.29	deleterious	-4.62	medium_impact	3.31	0.63	neutral	0.13	damaging	3.71	23.30	deleterious	0.04	0.35	NA	NA	0.76	disease	0.6	disease	0.67	disease	3	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.15	high_impact	0.20	0.8	45.53	8.78	0.32	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11148	11148	T	C	MI.17145	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	389	130	L	S	tTg/tCg	-0.17	0	0	probably_damaging	1	deleterious	0.01	neutral	4.36	neutral	-2.05	deleterious	-4.62	medium_impact	3.45	0.63	neutral	0.14	damaging	3.70	23.30	deleterious	0.04	0.35	NA	NA	0.76	disease	0.59	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-0.92	medium_impact	2.29	high_impact	0.28	0.8	45.53	8.78	0.33	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11149	11149	G	T	MI.17146	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	390	130	L	F	ttG/ttT	7.44	0.95	0.02	probably_damaging	1	neutral	0.19	neutral	4.61	neutral	0.84	deleterious	-3.08	low_impact	1.47	0.61	neutral	0.14	damaging	3.55	23.10	deleterious	0.21	0.45	NA	NA	0.69	disease	0.44	neutral	0.51	disease	0	1	deleterious	0.1	neutral	-2	neutral	0.82	deleterious	-3.54	low_impact	-0.15	medium_impact	0.33	medium_impact	0.57	0.8	45.53	8.78	0.5	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11149	11149	G	C	MI.17147	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	390	130	L	F	ttG/ttC	7.44	0.95	0.02	probably_damaging	1	neutral	0.19	neutral	4.61	neutral	0.84	deleterious	-3.08	low_impact	1.47	0.61	neutral	0.14	damaging	3.36	22.90	deleterious	0.21	0.45	NA	NA	0.69	disease	0.44	neutral	0.51	disease	0	1	deleterious	0.1	neutral	-2	neutral	0.82	deleterious	-3.54	low_impact	-0.15	medium_impact	0.33	medium_impact	0.57	0.8	45.53	8.78	0.5	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11150	11150	G	T	MI.17148	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	391	131	A	S	Gct/Tct	-6.16	0	0	benign	0.12	deleterious	0.01	neutral	4.6	neutral	-2.14	neutral	-0.85	low_impact	0.85	0.76	neutral	0.67	neutral	1.74	14.65	neutral	0.23	0.45	NA	NA	0.37	neutral	0.41	neutral	0.15	neutral	7	0.99	deleterious	0.45	neutral	-2	neutral	0.22	neutral	0.1	medium_impact	-0.92	medium_impact	-0.29	medium_impact	0.41	0.8	27.45	8.14	0.41	N	0.37	polymorphism	1	0.03	rs386829118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11150	11150	G	C	MI.17149	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	391	131	A	P	Gct/Cct	-6.16	0	0	benign	0.34	deleterious	0	neutral	4.59	neutral	-1.75	neutral	-1.6	low_impact	1.54	0.68	neutral	0.46	neutral	2.00	16.18	deleterious	0.06	0.35	NA	NA	0.78	disease	0.57	disease	0.74	disease	5	1	deleterious	0.33	neutral	-2	neutral	0.52	deleterious	-0.45	medium_impact	-1.48	low_impact	0.4	medium_impact	0.51	0.8	27.45	8.14	0.34	N	0.60	polymorphism	1	0.03	rs386829118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8494	8494	A	T	MI.1715	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	129	43	K	N	aaA/aaT	0.13	0	0	probably_damaging	0.99	neutral	0.44	neutral	1.53	neutral	-1.12	neutral	-2.44	low_impact	1.55	1	neutral	0.84	neutral	1.75	14.67	neutral	0.76472473	0.85	0.45	neutral	0.08	neutral	0.36	neutral	0.04	neutral	9	0.99	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-2.65	low_impact	0.23	medium_impact	0.23	medium_impact	0.66	0.85	4.41	8.93	0.49	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11150	11150	G	A	MI.17150	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	391	131	A	T	Gct/Act	-6.16	0	0	benign	0.06	deleterious	0	neutral	4.61	neutral	-1.86	neutral	-0.09	low_impact	1.2	0.77	neutral	0.67	neutral	2.23	17.74	deleterious	0.17	0.45	NA	NA	0.32	neutral	0.45	neutral	0.15	neutral	7	1	deleterious	0.47	deleterious	-2	neutral	0.16	neutral	0.41	medium_impact	-1.48	low_impact	0.06	medium_impact	0.63	0.8	27.45	8.14	0.45	N	0.30	polymorphism	1	0.01	rs386829118	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11151	11151	C	A	MI.17151	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	392	131	A	D	gCt/gAt	0.06	0	0.03	benign	0.34	deleterious	0	neutral	4.56	deleterious	-4.67	neutral	-1.69	low_impact	1.54	0.73	neutral	0.53	neutral	2.52	19.60	deleterious	0.02	0.35	NA	NA	0.67	disease	0.56	disease	0.65	disease	3	1	deleterious	0.33	neutral	-2	neutral	0.36	neutral	-0.45	medium_impact	-1.48	low_impact	0.4	medium_impact	0.34	0.8	27.45	8.14	0.38	N	0.60	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11151	11151	C	T	MI.17152	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	392	131	A	V	gCt/gTt	0.06	0	0.03	benign	0	neutral	0.35	neutral	4.72	neutral	-0.33	neutral	2.84	neutral_impact	-0.72	0.76	neutral	0.99	neutral	1.24	11.96	neutral	0.16	0.45	NA	NA	0.28	neutral	0.19	neutral	0.16	neutral	7	0.65	neutral	0.68	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.05	medium_impact	-1.84	low_impact	0.73	0.85	27.45	8.14	0.44	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11151	11151	C	G	MI.17153	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	392	131	A	G	gCt/gGt	0.06	0	0.03	benign	0.12	deleterious	0	neutral	4.6	neutral	-0.94	neutral	-2.31	neutral_impact	0.74	0.76	neutral	0.66	neutral	2.03	16.38	deleterious	0.18	0.45	NA	NA	0.39	neutral	0.38	neutral	0.15	neutral	7	1	deleterious	0.44	neutral	-2	neutral	0.23	neutral	0.1	medium_impact	-1.48	low_impact	-0.39	medium_impact	0.60	0.8	27.45	8.14	0.39	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11153	11153	A	C	MI.17154	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	394	132	I	L	Atc/Ctc	-8.01	0	0	probably_damaging	1	neutral	1	neutral	5.28	neutral	3.59	neutral	-1.37	neutral_impact	-0.2	0.75	neutral	0.77	neutral	2.53	19.64	deleterious	0.18	0.45	NA	NA	0.11	neutral	0.58	disease	0.24	neutral	5	1	deleterious	0.5	deleterious	-2	neutral	0.60	deleterious	-3.54	low_impact	1.88	high_impact	-1.32	low_impact	0.37	0.8	10.46	9.27	0.36	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11153	11153	A	T	MI.17155	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	394	132	I	F	Atc/Ttc	-8.01	0	0	probably_damaging	1	deleterious	0.01	neutral	4.55	neutral	-1.75	deleterious	-3	medium_impact	2.58	0.74	neutral	0.14	damaging	3.83	23.40	deleterious	0.04	0.35	NA	NA	0.66	disease	0.79	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-3.54	low_impact	-0.92	medium_impact	1.43	medium_impact	0.37	0.8	10.46	9.27	0.34	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11153	11153	A	G	MI.17156	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	394	132	I	V	Atc/Gtc	-8.01	0	0	probably_damaging	1	deleterious	0.03	neutral	4.66	neutral	-0.54	neutral	-0.66	medium_impact	2.17	0.79	neutral	0.77	neutral	1.87	15.43	deleterious	0.25	0.45	NA	NA	0.25	neutral	0.6	disease	0.36	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.62	deleterious	-3.54	low_impact	-0.64	medium_impact	1.02	medium_impact	0.48	0.8	10.46	9.27	0.41	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11154	11154	T	A	MI.17157	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	395	132	I	N	aTc/aAc	0.52	0.07	0	probably_damaging	1	deleterious	0	neutral	4.53	deleterious	-3.7	deleterious	-5.27	high_impact	3.62	0.74	neutral	0.15	damaging	4.32	24.00	deleterious	0.02	0.35	NA	NA	0.79	disease	0.78	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	2.46	high_impact	0.10	0.8	10.46	9.27	0.46	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11154	11154	T	G	MI.17158	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	395	132	I	S	aTc/aGc	0.52	0.07	0	probably_damaging	1	deleterious	0	neutral	4.58	neutral	-2.4	deleterious	-4.49	medium_impact	3.27	0.75	neutral	0.15	damaging	4.21	23.90	deleterious	0.01	0.35	NA	NA	0.76	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	2.11	high_impact	0.11	0.8	10.46	9.27	0.4	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11154	11154	T	C	MI.17159	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	395	132	I	T	aTc/aCc	0.52	0.07	0	probably_damaging	1	deleterious	0	neutral	4.56	neutral	-2.03	deleterious	-3.66	medium_impact	3.27	0.84	neutral	0.12	damaging	3.35	22.90	deleterious	0.02	0.35	NA	NA	0.62	disease	0.76	disease	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.72	deleterious	-3.54	low_impact	-1.48	low_impact	2.11	high_impact	0.13	0.8	10.46	9.27	0.38	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8495	8495	A	G	MI.1716	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	130	44	M	V	Ata/Gta	-0.8	0	0	possibly_damaging	0.75	neutral	0.44	neutral	1.99	neutral	-0.32	neutral	-0.81	low_impact	1.78	1	neutral	0.88	neutral	0.47	7.19	deleterious	0.84955088	0.90	0.2	neutral	0.13	neutral	0.49	neutral	0.1	neutral	8	0.75	neutral	0.35	neutral	-3	neutral	0.34	neutral	-1.21	low_impact	0.23	medium_impact	0.43	medium_impact	0.37	0.85	7.35	9.56	0.5	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11155	11155	C	G	MI.17160	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	396	132	I	M	atC/atG	7.44	0.96	0	probably_damaging	1	neutral	0.27	neutral	4.6	neutral	-1.03	neutral	-2.12	low_impact	1.68	0.82	neutral	0.27	damaging	3.28	22.80	deleterious	0.12	0.4	NA	NA	0.44	neutral	0.7	disease	0.43	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.70	deleterious	-3.54	low_impact	-0.04	medium_impact	0.54	medium_impact	0.35	0.8	10.46	9.27	0.54	P	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11155	11155	C	A	MI.17161	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	396	132	I	M	atC/atA	7.44	0.96	0	probably_damaging	1	neutral	0.27	neutral	4.6	neutral	-1.03	neutral	-2.12	low_impact	1.68	0.82	neutral	0.27	damaging	3.80	23.40	deleterious	0.12	0.4	NA	NA	0.44	neutral	0.7	disease	0.43	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.70	deleterious	-3.54	low_impact	-0.04	medium_impact	0.54	medium_impact	0.35	0.8	10.46	9.27	0.54	P	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11156	11156	A	C	MI.17162	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	397	133	I	L	Atc/Ctc	-7.78	0	0	probably_damaging	1	deleterious	0.03	neutral	4.29	neutral	-2.19	neutral	-1.5	medium_impact	3.13	0.53	damaging	0.12	damaging	3.74	23.30	deleterious	0.13	0.4	NA	NA	0.6	disease	0.73	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-3.54	low_impact	-0.64	medium_impact	1.97	medium_impact	0.31	0.8	46.84	9.25	0.37	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11156	11156	A	G	MI.17163	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	397	133	I	V	Atc/Gtc	-7.78	0	0	probably_damaging	1	neutral	0.05	neutral	4.35	neutral	-1.15	neutral	-0.76	medium_impact	2.69	0.57	damaging	0.16	damaging	3.01	22.30	deleterious	0.28	0.45	NA	NA	0.42	neutral	0.66	disease	0.4	neutral	2	1	deleterious	0.03	neutral	1	deleterious	0.69	deleterious	-3.54	low_impact	-0.52	medium_impact	1.54	medium_impact	0.44	0.8	46.84	9.25	0.4	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11156	11156	A	T	MI.17164	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	397	133	I	F	Atc/Ttc	-7.78	0	0	probably_damaging	1	deleterious	0	neutral	4.17	deleterious	-5.1	deleterious	-3.04	high_impact	4.11	0.55	damaging	0.14	damaging	3.71	23.30	deleterious	0.03	0.35	NA	NA	0.74	disease	0.79	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.94	high_impact	0.33	0.8	46.84	9.25	0.43	N	0.96	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11157	11157	T	G	MI.17165	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	398	133	I	S	aTc/aGc	8.59	1	0	probably_damaging	1	deleterious	0	neutral	4.19	deleterious	-5.08	deleterious	-4.58	high_impact	4.46	0.57	damaging	0.16	damaging	4.24	23.90	deleterious	0.01	0.35	NA	NA	0.83	disease	0.76	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.29	high_impact	0.12	0.8	46.84	9.25	0.59	P	0.95	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11157	11157	T	C	MI.17166	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	398	133	I	T	aTc/aCc	8.59	1	0	probably_damaging	1	deleterious	0	neutral	4.24	deleterious	-4.52	deleterious	-3.82	high_impact	4.11	0.6	neutral	0.13	damaging	3.37	22.90	deleterious	0.02	0.35	NA	NA	0.73	disease	0.76	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	2.94	high_impact	0.14	0.8	46.84	9.25	0.61	P	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11157	11157	T	A	MI.17167	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	398	133	I	N	aTc/aAc	8.59	1	0	probably_damaging	1	deleterious	0	neutral	4.18	deleterious	-6.43	deleterious	-5.35	high_impact	4.46	0.54	damaging	0.14	damaging	4.40	24.10	deleterious	0.02	0.35	NA	NA	0.83	disease	0.78	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.29	high_impact	0.07	0.8	46.84	9.25	0.59	P	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11158	11158	C	A	MI.17168	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	399	133	I	M	atC/atA	7.44	1	0	probably_damaging	1	deleterious	0.01	neutral	4.19	deleterious	-4.18	neutral	-2.21	high_impact	3.65	0.6	damaging	0.14	damaging	3.69	23.30	deleterious	0.05	0.35	NA	NA	0.64	disease	0.77	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-3.54	low_impact	-0.92	medium_impact	2.49	high_impact	0.35	0.8	46.84	9.25	0.61	P	0.76	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11158	11158	C	G	MI.17169	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	399	133	I	M	atC/atG	7.44	1	0	probably_damaging	1	deleterious	0.01	neutral	4.19	deleterious	-4.18	neutral	-2.21	high_impact	3.65	0.6	damaging	0.14	damaging	3.25	22.80	deleterious	0.05	0.35	NA	NA	0.64	disease	0.77	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-3.54	low_impact	-0.92	medium_impact	2.49	high_impact	0.35	0.8	46.84	9.25	0.6	P	0.76	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8495	8495	A	T	MI.1717	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	130	44	M	L	Ata/Tta	-0.8	0	0	possibly_damaging	0.66	neutral	0.45	neutral	2.09	neutral	1.4	neutral	-0.78	neutral_impact	0.68	1	neutral	0.95	neutral	1.00	10.66	neutral	0.70300388	0.85	0.18	neutral	0.07	neutral	0.34	neutral	0.04	neutral	9	0.65	neutral	0.4	neutral	-3	neutral	0.30	neutral	-1.03	low_impact	0.24	medium_impact	-0.52	medium_impact	0.47	0.85	7.35	9.56	0.52	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11159	11159	A	T	MI.17170	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	400	134	T	S	Acc/Tcc	-5.47	0	0	probably_damaging	1	neutral	0.42	neutral	4.75	neutral	0.13	deleterious	-2.86	low_impact	1.83	0.69	neutral	0.66	neutral	3.22	22.70	deleterious	0.4	0.5	NA	NA	0.56	disease	0.4	neutral	0.45	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.80	deleterious	-3.54	low_impact	0.12	medium_impact	0.68	medium_impact	0.64	0.8	44.01	8.3	0.38	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11159	11159	A	C	MI.17171	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	400	134	T	P	Acc/Ccc	-5.47	0	0	probably_damaging	1	neutral	0.2	neutral	4.57	neutral	-2.9	deleterious	-4.44	medium_impact	3.5	0.67	neutral	0.46	neutral	3.41	23.00	deleterious	0.04	0.35	NA	NA	0.81	disease	0.78	disease	0.76	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	-0.14	medium_impact	2.34	high_impact	0.34	0.8	44.01	8.3	0.44	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11159	11159	A	G	MI.17172	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	400	134	T	A	Acc/Gcc	-5.47	0	0	probably_damaging	1	neutral	0.5	neutral	4.68	neutral	1.3	deleterious	-3.52	low_impact	1.83	0.67	neutral	0.7	neutral	3.43	23.00	deleterious	0.29	0.45	NA	NA	0.54	disease	0.58	disease	0.57	disease	1	1	deleterious	0.25	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	0.2	medium_impact	0.68	medium_impact	0.28	0.8	44.01	8.3	0.34	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11160	11160	C	A	MI.17173	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	401	134	T	N	aCc/aAc	4.67	1	0	probably_damaging	1	neutral	0.31	neutral	4.61	neutral	-1.76	deleterious	-3.72	medium_impact	3.15	0.71	neutral	0.5	neutral	3.62	23.20	deleterious	0.24	0.45	NA	NA	0.75	disease	0.67	disease	0.69	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.01	medium_impact	1.99	medium_impact	0.51	0.8	44.01	8.3	0.61	P	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11160	11160	C	T	MI.17174	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	401	134	T	I	aCc/aTc	4.67	1	0	probably_damaging	1	neutral	0.46	neutral	4.64	neutral	0.02	deleterious	-4.44	low_impact	1.62	0.72	neutral	0.58	neutral	3.92	23.50	deleterious	0.12	0.4	NA	NA	0.71	disease	0.63	disease	0.55	disease	1	1	deleterious	0.23	neutral	-2	neutral	0.83	deleterious	-3.54	low_impact	0.16	medium_impact	0.48	medium_impact	0.66	0.8	44.01	8.3	0.51	P	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11160	11160	C	G	MI.17175	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	401	134	T	S	aCc/aGc	4.67	1	0	probably_damaging	1	neutral	0.42	neutral	4.75	neutral	0.13	deleterious	-2.86	low_impact	1.83	0.69	neutral	0.66	neutral	3.46	23.00	deleterious	0.4	0.5	NA	NA	0.56	disease	0.4	neutral	0.45	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.80	deleterious	-3.54	low_impact	0.12	medium_impact	0.68	medium_impact	0.64	0.8	44.01	8.3	0.55	P	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11162	11162	C	G	MI.17176	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	403	135	R	G	Cga/Gga	-11.7	0	0	possibly_damaging	0.88	neutral	0.83	neutral	4.64	neutral	0.03	deleterious	-5.39	low_impact	0.82	0.64	neutral	0.4	neutral	4.16	23.80	deleterious	0.09	0.35	NA	NA	0.48	neutral	0.7	disease	0.39	neutral	2	0.86	neutral	0.48	deleterious	-3	neutral	0.79	deleterious	-1.53	low_impact	0.59	medium_impact	-0.32	medium_impact	0.19	0.8	14.38	16.18	0.26	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11162	11162	C	T	MI.17177	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	403	135	R	W	Cga/Tga	-11.7	0	0	probably_damaging	0.99	neutral	0.19	neutral	4.63	neutral	-2.47	deleterious	-6.17	medium_impact	2.65	0.63	neutral	0.22	damaging	5.15	25.40	deleterious	0.13	0.4	NA	NA	0.9	disease	0.78	disease	0.81	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.89	deleterious	-2.59	low_impact	-0.15	medium_impact	1.5	medium_impact	0.66	0.8	14.38	16.18	0.35	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11163	11163	G	C	MI.17178	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	404	135	R	P	cGa/cCa	3.52	0.97	0	probably_damaging	0.97	neutral	0.27	neutral	4.6	neutral	-2.61	deleterious	-5.4	high_impact	3.54	0.61	neutral	0.3	neutral	4.28	24.00	deleterious	0.02	0.35	NA	NA	0.91	disease	0.87	disease	0.87	disease	7	0.97	neutral	0.15	neutral	2	deleterious	0.91	deleterious	-2.14	low_impact	-0.04	medium_impact	2.38	high_impact	0.12	0.8	14.38	16.18	0.55	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11163	11163	G	T	MI.17179	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	404	135	R	L	cGa/cTa	3.52	0.97	0	possibly_damaging	0.88	neutral	0.72	neutral	4.77	neutral	1.37	deleterious	-5.41	low_impact	1.76	0.64	neutral	0.35	neutral	4.34	24.00	deleterious	0.09	0.35	NA	NA	0.91	disease	0.78	disease	0.81	disease	6	0.85	neutral	0.42	neutral	-3	neutral	0.88	deleterious	-1.53	low_impact	0.43	medium_impact	0.62	medium_impact	0.05	0.8	14.38	16.18	0.47	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8495	8495	A	C	MI.1718	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	130	44	M	L	Ata/Cta	-0.8	0	0	possibly_damaging	0.66	neutral	0.45	neutral	2.09	neutral	1.4	neutral	-0.78	neutral_impact	0.68	1	neutral	0.95	neutral	0.92	10.21	neutral	0.70300388	0.85	0.18	neutral	0.07	neutral	0.34	neutral	0.04	neutral	9	0.65	neutral	0.4	neutral	-3	neutral	0.30	neutral	-1.03	low_impact	0.24	medium_impact	-0.52	medium_impact	0.47	0.85	7.35	9.56	0.53	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11163	11163	G	A	MI.17180	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	404	135	R	Q	cGa/cAa	3.52	0.97	0	possibly_damaging	0.83	neutral	0.43	neutral	4.61	neutral	-1.52	deleterious	-3.08	medium_impact	2.65	0.64	neutral	0.28	damaging	4.45	24.20	deleterious	0.2	0.45	NA	NA	0.83	disease	0.79	disease	0.8	disease	6	0.83	neutral	0.3	neutral	0	NA	0.83	deleterious	-1.37	low_impact	0.13	medium_impact	1.5	medium_impact	0.81	0.85	14.38	16.18	0.55	P	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11165	11165	T	C	MI.17181	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	406	136	W	R	Tga/Cga	-4.09	0	0	probably_damaging	1	deleterious	0	neutral	4.46	neutral	-2.3	deleterious	-10.83	high_impact	4.45	0.64	neutral	0.12	damaging	3.52	23.10	deleterious	0.04	0.35	NA	NA	0.91	disease	0.88	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.28	high_impact	0.03	0.8	47.28	9.26	0.58	P	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11165	11165	T	G	MI.17182	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	406	136	W	G	Tga/Gga	-4.09	0	0	probably_damaging	1	neutral	0.05	neutral	4.48	neutral	-2.8	deleterious	-10.06	high_impact	3.9	0.63	neutral	0.17	damaging	3.83	23.40	deleterious	0.05	0.35	NA	NA	0.86	disease	0.85	disease	0.81	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	-0.52	medium_impact	2.73	high_impact	0.04	0.8	47.28	9.26	0.49	N	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11166	11166	G	T	MI.17183	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	407	136	W	L	tGa/tTa	7.44	1	0	probably_damaging	1	deleterious	0.01	neutral	4.51	neutral	-2.69	deleterious	-10.06	high_impact	3.55	0.62	neutral	0.13	damaging	4.20	23.90	deleterious	0.06	0.35	NA	NA	0.86	disease	0.84	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-0.92	medium_impact	2.39	high_impact	0.06	0.8	47.28	9.26	0.62	P	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11166	11166	G	C	MI.17184	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	407	136	W	S	tGa/tCa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	4.46	neutral	-2.58	deleterious	-10.83	high_impact	3.75	0.64	neutral	0.17	damaging	3.98	23.60	deleterious	0.05	0.35	NA	NA	0.92	disease	0.84	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	2.58	high_impact	0.04	0.8	47.28	9.26	0.63	P	0.93	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11167	11167	A	T	MI.17185	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	408	136	W	C	tgA/tgT	7.21	1	0.02	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-5.13	deleterious	-10.06	high_impact	4.1	0.63	neutral	0.11	damaging	4.06	23.70	deleterious	0.04	0.35	NA	NA	0.9	disease	0.87	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.93	high_impact	0.08	0.8	47.28	9.26	0.61	P	0.98	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11167	11167	A	C	MI.17186	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	408	136	W	C	tgA/tgC	7.21	1	0.02	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-5.13	deleterious	-10.06	high_impact	4.1	0.63	neutral	0.11	damaging	3.98	23.60	deleterious	0.04	0.35	NA	NA	0.9	disease	0.87	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.93	high_impact	0.08	0.8	47.28	9.26	0.61	P	0.98	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11168	11168	G	T	MI.17187	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	409	137	G	C	Ggc/Tgc	0.06	0.94	0	probably_damaging	1	deleterious	0	neutral	4.49	deleterious	-6.5	deleterious	-6.96	high_impact	4.5	0.32	damaging	0.03	damaging	4.17	23.80	deleterious	0.08	0.35	NA	NA	0.89	disease	0.69	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.09	0.8	47.49	9.15	0.63	P	0.98	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11168	11168	G	C	MI.17188	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	409	137	G	R	Ggc/Cgc	0.06	0.94	0	probably_damaging	1	deleterious	0	neutral	4.58	neutral	-1.7	deleterious	-6.19	high_impact	4.5	0.39	damaging	0.04	damaging	3.93	23.50	deleterious	0.08	0.35	NA	NA	0.87	disease	0.73	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.58	0.8	47.49	9.15	0.67	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11168	11168	G	A	MI.17189	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	409	137	G	S	Ggc/Agc	0.06	0.94	0	probably_damaging	1	neutral	0.06	neutral	4.59	neutral	-2.42	deleterious	-4.64	medium_impact	3.26	0.34	damaging	0.07	damaging	4.12	23.80	deleterious	0.13	0.4	NA	NA	0.85	disease	0.67	disease	0.74	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.88	deleterious	-3.54	low_impact	-0.47	medium_impact	2.1	high_impact	0.50	0.8	47.49	9.15	0.64	P	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8496	8496	T	A	MI.1719	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	131	44	M	K	aTa/aAa	-5.19	0	0	possibly_damaging	0.88	neutral	1	neutral	2.06	neutral	1.08	neutral	-1.44	neutral_impact	0.44	1	neutral	0.84	neutral	2.65	20.50	deleterious	0.44486802	0.85	0.45	neutral	0.26	neutral	0.33	neutral	0.13	neutral	8	0.88	neutral	0.56	deleterious	-3	neutral	0.58	deleterious	-1.58	low_impact	1.98	high_impact	-0.72	medium_impact	0.43	0.85	7.35	9.56	0.31	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11169	11169	G	A	MI.17190	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	410	137	G	D	gGc/gAc	5.13	1	0	probably_damaging	1	deleterious	0	neutral	4.54	neutral	-2.91	deleterious	-5.42	high_impact	4.5	0.3	damaging	0.05	damaging	3.80	23.40	deleterious	0.08	0.35	NA	NA	0.88	disease	0.75	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.13	0.8	47.49	9.15	0.78	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11169	11169	G	C	MI.17191	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	410	137	G	A	gGc/gCc	5.13	1	0	probably_damaging	1	deleterious	0	neutral	4.55	neutral	-2.45	deleterious	-4.64	high_impact	4.5	0.46	damaging	0.07	damaging	3.08	22.50	deleterious	0.17	0.45	NA	NA	0.76	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.36	0.8	47.49	9.15	0.64	P	0.76	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11169	11169	G	T	MI.17192	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	410	137	G	V	gGc/gTc	5.13	1	0	probably_damaging	1	deleterious	0	neutral	4.51	deleterious	-3.95	deleterious	-6.96	high_impact	4.5	0.38	damaging	0.05	damaging	3.73	23.30	deleterious	0.07	0.35	NA	NA	0.88	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.08	0.8	47.49	9.15	0.7	P	0.98	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11171	11171	A	C	MI.17193	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	412	138	N	H	Aac/Cac	-9.16	0	0	possibly_damaging	0.76	neutral	0.46	neutral	4.57	neutral	-0.4	deleterious	-3.58	low_impact	1.52	0.73	neutral	0.44	neutral	3.11	22.50	deleterious	0.67	0.7	NA	NA	0.67	disease	0.39	neutral	0.51	disease	0	0.75	neutral	0.35	neutral	-3	neutral	0.78	deleterious	-1.19	low_impact	0.16	medium_impact	0.38	medium_impact	0.11	0.8	18.52	17.16	0.27	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11171	11171	A	T	MI.17194	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	412	138	N	Y	Aac/Tac	-9.16	0	0	benign	0.03	neutral	1	neutral	4.63	neutral	-1.56	deleterious	-5.64	neutral_impact	0.03	0.67	neutral	0.61	neutral	3.68	23.30	deleterious	0.23	0.45	NA	NA	0.52	disease	0.38	neutral	0.45	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.76	deleterious	0.7	medium_impact	1.88	high_impact	-1.1	low_impact	0.16	0.8	18.52	17.16	0.25	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	COSM6716732	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11171	11171	A	G	MI.17195	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	412	138	N	D	Aac/Gac	-9.16	0	0	benign	0.37	neutral	0.18	neutral	4.62	neutral	0.44	deleterious	-3.68	medium_impact	2.4	0.75	neutral	0.48	neutral	3.83	23.40	deleterious	0.81	0.85	NA	NA	0.65	disease	0.6	disease	0.67	disease	3	0.79	neutral	0.41	neutral	-3	neutral	0.78	deleterious	-0.5	medium_impact	-0.17	medium_impact	1.25	medium_impact	0.28	0.8	18.52	17.16	0.37	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11172	11172	A	C	MI.17196	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	413	138	N	T	aAc/aCc	4.67	0.69	0	benign	0.03	neutral	0.33	neutral	4.65	neutral	0.52	deleterious	-4.36	medium_impact	2.29	0.77	neutral	0.56	neutral	3.82	23.40	deleterious	0.59	0.65	NA	NA	0.68	disease	0.33	neutral	0.5	disease	0	0.65	neutral	0.65	deleterious	-3	neutral	0.75	deleterious	0.7	medium_impact	0.03	medium_impact	1.14	medium_impact	0.27	0.8	18.52	17.16	0.38	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11172	11172	A	G	MI.17197	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	413	138	N	S	aAc/aGc	4.67	0.69	0	benign	0.03	neutral	0.41	neutral	4.64	neutral	0.45	deleterious	-3.59	neutral_impact	0.18	0.72	neutral	0.83	neutral	2.48	19.36	deleterious	0.77	0.8	NA	NA	0.55	disease	0.35	neutral	0.46	neutral	1	0.56	neutral	0.69	deleterious	-6	neutral	0.77	deleterious	0.7	medium_impact	0.11	medium_impact	-0.95	medium_impact	0.29	0.8	18.52	17.16	0.31	N	0.85	polymorphism	1	0.07	rs2853489	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11172	11172	A	T	MI.17198	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	413	138	N	I	aAc/aTc	4.67	0.69	0	benign	0.03	neutral	0.33	neutral	4.58	neutral	-2.41	deleterious	-6.57	medium_impact	2.2	0.72	neutral	0.53	neutral	4.41	24.10	deleterious	0.2	0.45	NA	NA	0.81	disease	0.59	disease	0.7	disease	4	0.65	neutral	0.65	deleterious	-3	neutral	0.82	deleterious	0.7	medium_impact	0.03	medium_impact	1.05	medium_impact	0.10	0.8	18.52	17.16	0.41	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11173	11173	C	A	MI.17199	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	414	138	N	K	aaC/aaA	1.68	0.54	0	benign	0.37	neutral	0.24	neutral	4.75	neutral	0.73	deleterious	-4.39	low_impact	1.74	0.77	neutral	0.38	neutral	4.41	24.10	deleterious	0.68	0.7	NA	NA	0.77	disease	0.62	disease	0.7	disease	4	0.72	neutral	0.44	neutral	-6	neutral	0.82	deleterious	-0.5	medium_impact	-0.08	medium_impact	0.6	medium_impact	0.38	0.8	18.52	17.16	0.28	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8606	8606	C	A	MI.172	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	80	27	P	H	cCc/cAc	5.45	1	0	probably_damaging	1	neutral	0.54	neutral	4.34	neutral	-2.05	deleterious	-8.12	high_impact	3.86	0.73	neutral	0.43	neutral	3.83	23.40	deleterious	0.28	0.65	0.39	neutral	0.82	disease	0.7	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.33	medium_impact	2.21	high_impact	0.46	0.9	48.23	8.81	0.49	N	0.67	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8496	8496	T	C	MI.1720	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	131	44	M	T	aTa/aCa	-5.19	0	0	possibly_damaging	0.88	neutral	0.67	neutral	2.1	neutral	1.46	neutral	0.24	neutral_impact	-0.7	1	neutral	0.98	neutral	0.29	5.57	deleterious	0.81027320	0.90	0.12	neutral	0.14	neutral	0.41	neutral	0.07	neutral	9	0.86	neutral	0.4	neutral	-3	neutral	0.51	deleterious	-1.58	low_impact	0.47	medium_impact	-1.7	low_impact	0.16	0.85	7.35	9.56	0.41	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11173	11173	C	G	MI.17200	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	414	138	N	K	aaC/aaG	1.68	0.54	0	benign	0.37	neutral	0.24	neutral	4.75	neutral	0.73	deleterious	-4.39	low_impact	1.74	0.77	neutral	0.38	neutral	3.97	23.60	deleterious	0.68	0.7	NA	NA	0.77	disease	0.62	disease	0.7	disease	4	0.72	neutral	0.44	neutral	-6	neutral	0.82	deleterious	-0.5	medium_impact	-0.08	medium_impact	0.6	medium_impact	0.38	0.8	18.52	17.16	0.28	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11174	11174	C	A	MI.17201	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	415	139	Q	K	Cag/Aag	-4.55	0	0	probably_damaging	1	deleterious	0	neutral	4.72	neutral	1.44	deleterious	-3.1	medium_impact	2.91	0.63	neutral	0.14	damaging	3.98	23.60	deleterious	0.49	0.55	NA	NA	0.86	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	5	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	1.75	medium_impact	0.24	0.8	46.62	9.3	0.34	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11174	11174	C	G	MI.17202	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	415	139	Q	E	Cag/Gag	-4.55	0	0	probably_damaging	1	deleterious	0	neutral	4.6	neutral	0.5	neutral	-2.32	medium_impact	2.71	0.68	neutral	0.13	damaging	3.04	22.40	deleterious	0.55	0.6	NA	NA	0.79	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	1.56	medium_impact	0.28	0.8	46.62	9.3	0.29	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11175	11175	A	T	MI.17203	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	416	139	Q	L	cAg/cTg	5.6	1	0	probably_damaging	1	deleterious	0	neutral	4.54	neutral	-1.31	deleterious	-5.42	high_impact	3.75	0.64	neutral	0.09	damaging	3.89	23.50	deleterious	0.12	0.4	NA	NA	0.88	disease	0.66	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.58	high_impact	0.11	0.8	46.62	9.3	0.61	P	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11175	11175	A	C	MI.17204	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	416	139	Q	P	cAg/cCg	5.6	1	0	probably_damaging	1	deleterious	0	neutral	4.52	neutral	-2.6	deleterious	-4.64	medium_impact	2.98	0.64	neutral	0.14	damaging	3.37	22.90	deleterious	0.09	0.35	NA	NA	0.88	disease	0.65	disease	0.73	disease	5	1	deleterious	0	neutral	5	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	1.82	medium_impact	0.17	0.8	46.62	9.3	0.52	P	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11175	11175	A	G	MI.17205	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	416	139	Q	R	cAg/cGg	5.6	1	0	probably_damaging	1	neutral	0.08	neutral	4.64	neutral	1.08	deleterious	-3.1	medium_impact	2.58	0.67	neutral	0.11	damaging	3.52	23.10	deleterious	0.5	0.6	NA	NA	0.84	disease	0.71	disease	0.76	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	-0.39	medium_impact	1.43	medium_impact	0.20	0.8	46.62	9.3	0.58	P	0.88	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11176	11176	G	T	MI.17206	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	417	139	Q	H	caG/caT	8.59	1	0.01	probably_damaging	1	deleterious	0.01	neutral	4.53	neutral	-1.82	deleterious	-3.87	high_impact	3.75	0.64	neutral	0.1	damaging	3.55	23.10	deleterious	0.33	0.5	NA	NA	0.79	disease	0.71	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-0.92	medium_impact	2.58	high_impact	0.31	0.8	46.62	9.3	0.6	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11176	11176	G	C	MI.17207	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	417	139	Q	H	caG/caC	8.59	1	0.01	probably_damaging	1	deleterious	0.01	neutral	4.53	neutral	-1.82	deleterious	-3.87	high_impact	3.75	0.64	neutral	0.1	damaging	3.42	23.00	deleterious	0.33	0.5	NA	NA	0.79	disease	0.71	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-0.92	medium_impact	2.58	high_impact	0.31	0.8	46.62	9.3	0.6	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11177	11177	C	A	MI.17208	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	418	140	P	T	Cca/Aca	0.75	0.21	0.01	benign	0.04	neutral	0.41	neutral	4.56	neutral	-1.82	neutral	2.73	neutral_impact	0.7	0.71	neutral	0.97	neutral	1.05	10.94	neutral	0.3	0.45	NA	NA	0.15	neutral	0.15	neutral	0.22	neutral	6	0.56	neutral	0.69	deleterious	-6	neutral	0.66	deleterious	0.58	medium_impact	0.11	medium_impact	-0.43	medium_impact	0.48	0.8	31.59	28.53	0.47	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11177	11177	C	T	MI.17209	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	418	140	P	S	Cca/Tca	0.75	0.21	0.01	benign	0.36	neutral	0.2	neutral	4.62	neutral	-1.35	neutral	0.85	medium_impact	2.13	0.76	neutral	0.84	neutral	3.73	23.30	deleterious	0.29	0.45	NA	NA	0.47	neutral	0.34	neutral	0.34	neutral	3	0.76	neutral	0.42	neutral	-3	neutral	0.73	deleterious	-0.48	medium_impact	-0.14	medium_impact	0.98	medium_impact	0.27	0.8	31.59	28.53	0.41	N	0.44	polymorphism	1	0.02	rs28358284	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8497	8497	A	T	MI.1721	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	132	44	M	I	atA/atT	-6.35	0	0	possibly_damaging	0.82	neutral	0.36	neutral	1.99	neutral	-0.42	neutral	-1.11	low_impact	1.01	1	neutral	0.95	neutral	1.49	13.26	neutral	0.75672260	0.85	0.18	neutral	0.04	neutral	0.35	neutral	0.04	neutral	9	0.83	neutral	0.27	neutral	-3	neutral	0.42	neutral	-1.38	low_impact	0.15	medium_impact	-0.23	medium_impact	0.38	0.85	7.35	9.56	0.53	P	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11177	11177	C	G	MI.17210	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	418	140	P	A	Cca/Gca	0.75	0.21	0.01	benign	0.01	neutral	0.22	neutral	4.59	neutral	-0.87	neutral	0.56	low_impact	1.25	0.74	neutral	0.96	neutral	1.07	11.06	neutral	0.32	0.5	NA	NA	0.17	neutral	0.19	neutral	0.23	neutral	5	0.77	neutral	0.61	deleterious	-6	neutral	0.69	deleterious	1.16	medium_impact	-0.11	medium_impact	0.11	medium_impact	0.39	0.8	31.59	28.53	0.49	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11178	11178	C	G	MI.17211	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	419	140	P	R	cCa/cGa	0.06	0	0	possibly_damaging	0.75	deleterious	0.03	neutral	4.54	neutral	-1.31	neutral	-0.57	medium_impact	2.98	0.8	neutral	0.46	neutral	3.51	23.10	deleterious	0.12	0.4	NA	NA	0.68	disease	0.46	neutral	0.51	disease	0	0.98	neutral	0.14	neutral	4	deleterious	0.77	deleterious	-1.17	low_impact	-0.64	medium_impact	1.82	medium_impact	0.16	0.8	31.59	28.53	0.39	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11178	11178	C	A	MI.17212	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	419	140	P	Q	cCa/cAa	0.06	0	0	possibly_damaging	0.81	deleterious	0.04	neutral	4.6	neutral	-1.88	neutral	-0.48	low_impact	1.75	0.77	neutral	0.78	neutral	3.97	23.60	deleterious	0.17	0.45	NA	NA	0.51	disease	0.29	neutral	0.5	neutral	0	0.97	neutral	0.12	neutral	1	deleterious	0.72	deleterious	-1.31	low_impact	-0.57	medium_impact	0.61	medium_impact	0.26	0.8	31.59	28.53	0.43	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11178	11178	C	T	MI.17213	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	419	140	P	L	cCa/cTa	0.06	0	0	benign	0.36	neutral	0.05	neutral	4.6	neutral	-2.64	neutral	-0.55	medium_impact	2.09	0.79	neutral	0.72	neutral	4.32	24.00	deleterious	0.17	0.45	NA	NA	0.58	disease	0.38	neutral	0.49	neutral	0	0.94	neutral	0.35	neutral	-3	neutral	0.74	deleterious	-0.48	medium_impact	-0.52	medium_impact	0.94	medium_impact	0.56	0.8	31.59	28.53	0.41	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11180	11180	G	A	MI.17214	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	421	141	E	K	Gaa/Aaa	-0.63	0	0	benign	0.3	deleterious	0.01	neutral	4.64	neutral	-0.57	deleterious	-3	medium_impact	2.94	0.57	damaging	0.46	neutral	4.45	24.20	deleterious	0.2	0.45	NA	NA	0.9	disease	0.58	disease	0.69	disease	4	0.99	deleterious	0.36	neutral	1	deleterious	0.91	deleterious	-0.37	medium_impact	-0.92	medium_impact	1.78	medium_impact	0.72	0.85	42.48	8.42	0.38	N	0.41	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11180	11180	G	C	MI.17215	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	421	141	E	Q	Gaa/Caa	-0.63	0	0	probably_damaging	0.94	deleterious	0.02	neutral	4.51	neutral	-1.06	neutral	-2.25	medium_impact	3.07	0.59	damaging	0.57	neutral	3.35	22.90	deleterious	0.47	0.55	NA	NA	0.78	disease	0.51	disease	0.6	disease	2	0.99	deleterious	0.04	neutral	5	deleterious	0.84	deleterious	-1.84	low_impact	-0.75	medium_impact	1.91	medium_impact	0.37	0.8	42.48	8.42	0.41	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11181	11181	A	C	MI.17216	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	422	141	E	A	gAa/gCa	7.44	1	0	possibly_damaging	0.9	deleterious	0.01	neutral	4.53	neutral	-0.51	deleterious	-4.39	medium_impact	3.07	0.61	neutral	0.66	neutral	3.62	23.20	deleterious	0.18	0.45	NA	NA	0.82	disease	0.55	disease	0.69	disease	4	1	deleterious	0.06	neutral	4	deleterious	0.87	deleterious	-1.61	low_impact	-0.92	medium_impact	1.91	medium_impact	0.43	0.8	42.48	8.42	0.6	P	0.77	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11181	11181	A	G	MI.17217	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	422	141	E	G	gAa/gGa	7.44	1	0	probably_damaging	0.96	deleterious	0.01	neutral	4.48	neutral	-2.17	deleterious	-5.23	medium_impact	3.25	0.57	damaging	0.58	neutral	4.17	23.80	deleterious	0.18	0.45	NA	NA	0.8	disease	0.62	disease	0.69	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.87	deleterious	-2.01	low_impact	-0.92	medium_impact	2.09	high_impact	0.19	0.8	42.48	8.42	0.56	P	0.87	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11181	11181	A	T	MI.17218	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	422	141	E	V	gAa/gTa	7.44	1	0	probably_damaging	0.98	deleterious	0	neutral	4.47	neutral	-2.68	deleterious	-5.23	high_impact	3.67	0.56	damaging	0.48	neutral	4.05	23.70	deleterious	0.09	0.35	NA	NA	0.9	disease	0.62	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.31	low_impact	-1.48	low_impact	2.51	high_impact	0.47	0.8	42.48	8.42	0.58	P	0.93	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11182	11182	A	C	MI.17219	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	423	141	E	D	gaA/gaC	8.59	1	0	probably_damaging	0.92	deleterious	0.03	neutral	4.54	neutral	-1.33	neutral	-2.27	low_impact	1.88	0.6	damaging	0.62	neutral	3.63	23.20	deleterious	0.55	0.6	NA	NA	0.74	disease	0.46	neutral	0.49	neutral	0	0.99	deleterious	0.06	neutral	2	deleterious	0.86	deleterious	-1.71	low_impact	-0.64	medium_impact	0.73	medium_impact	0.35	0.8	42.48	8.42	0.61	P	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8497	8497	A	C	MI.1722	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	132	44	M	I	atA/atC	-6.35	0	0	possibly_damaging	0.82	neutral	0.36	neutral	1.99	neutral	-0.42	neutral	-1.11	low_impact	1.01	1	neutral	0.95	neutral	1.41	12.85	neutral	0.75672260	0.85	0.18	neutral	0.04	neutral	0.35	neutral	0.04	neutral	9	0.83	neutral	0.27	neutral	-3	neutral	0.42	neutral	-1.38	low_impact	0.15	medium_impact	-0.23	medium_impact	0.38	0.85	7.35	9.56	0.53	P	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11182	11182	A	T	MI.17220	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	423	141	E	D	gaA/gaT	8.59	1	0	probably_damaging	0.92	deleterious	0.03	neutral	4.54	neutral	-1.33	neutral	-2.27	low_impact	1.88	0.6	damaging	0.62	neutral	3.73	23.30	deleterious	0.55	0.6	NA	NA	0.74	disease	0.46	neutral	0.49	neutral	0	0.99	deleterious	0.06	neutral	2	deleterious	0.86	deleterious	-1.71	low_impact	-0.64	medium_impact	0.73	medium_impact	0.35	0.8	42.48	8.42	0.62	P	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11183	11183	C	T	MI.17221	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	424	142	R	C	Cgc/Tgc	-0.17	0.57	0	probably_damaging	1	deleterious	0	neutral	4.48	deleterious	-6.01	deleterious	-6.18	high_impact	4.45	0.44	damaging	0.01	damaging	4.94	25.00	deleterious	0.06	0.35	NA	NA	0.92	disease	0.74	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.28	high_impact	0.75	0.85	46.19	9.45	0.56	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11183	11183	C	G	MI.17222	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	424	142	R	G	Cgc/Ggc	-0.17	0.57	0	probably_damaging	1	deleterious	0	neutral	4.52	neutral	-2.97	deleterious	-5.41	high_impact	3.9	0.46	damaging	0.05	damaging	4.14	23.80	deleterious	0.05	0.35	NA	NA	0.83	disease	0.74	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.73	high_impact	0.19	0.8	46.19	9.45	0.43	N	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11183	11183	C	A	MI.17223	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	424	142	R	S	Cgc/Agc	-0.17	0.57	0	probably_damaging	1	deleterious	0	neutral	4.77	neutral	-0.64	deleterious	-4.64	high_impact	3.56	0.44	damaging	0.04	damaging	4.65	24.50	deleterious	0.05	0.35	NA	NA	0.89	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.4	high_impact	0.19	0.8	46.19	9.45	0.51	N	0.81	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11184	11184	G	A	MI.17224	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	425	142	R	H	cGc/cAc	1.68	0.95	0	probably_damaging	1	deleterious	0	neutral	4.5	deleterious	-3.24	deleterious	-3.87	high_impact	4.45	0.49	damaging	0.02	damaging	4.49	24.30	deleterious	0.12	0.4	NA	NA	0.87	disease	0.69	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.28	high_impact	0.85	0.9	46.19	9.45	0.56	P	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11184	11184	G	T	MI.17225	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	425	142	R	L	cGc/cTc	1.68	0.95	0	probably_damaging	1	deleterious	0	neutral	4.5	neutral	-2.97	deleterious	-5.41	high_impact	4.45	0.47	damaging	0.02	damaging	4.28	24.00	deleterious	0.04	0.35	NA	NA	0.94	disease	0.71	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.28	high_impact	0.05	0.8	46.19	9.45	0.58	P	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11184	11184	G	C	MI.17226	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	425	142	R	P	cGc/cCc	1.68	0.95	0	probably_damaging	1	deleterious	0.01	neutral	4.49	deleterious	-3.64	deleterious	-5.41	high_impact	4.11	0.44	damaging	0.02	damaging	4.19	23.80	deleterious	0.02	0.35	NA	NA	0.91	disease	0.82	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.92	deleterious	-3.54	low_impact	-0.92	medium_impact	2.94	high_impact	0.09	0.8	46.19	9.45	0.61	P	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11186	11186	C	G	MI.17227	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	427	143	L	V	Ctg/Gtg	-6.63	0	0	probably_damaging	1	neutral	0.14	neutral	4.59	neutral	-0.47	neutral	-2.19	medium_impact	2.1	0.61	neutral	0.1	damaging	3.33	22.90	deleterious	0.27	0.45	NA	NA	0.56	disease	0.53	disease	0.47	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.24	medium_impact	0.95	medium_impact	0.34	0.8	40.09	8.36	0.3	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11186	11186	C	A	MI.17228	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	427	143	L	M	Ctg/Atg	-6.63	0	0	probably_damaging	1	deleterious	0.04	neutral	4.5	neutral	-1.6	neutral	-1.24	medium_impact	2.74	0.73	neutral	0.4	neutral	3.65	23.20	deleterious	0.25	0.45	NA	NA	0.51	disease	0.35	neutral	0.46	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.57	medium_impact	1.59	medium_impact	0.48	0.8	40.09	8.36	0.45	N	0.28	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11187	11187	T	A	MI.17229	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	428	143	L	Q	cTg/cAg	0.29	0.02	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-3.23	deleterious	-4.4	medium_impact	3.29	0.59	damaging	0.1	damaging	4.12	23.80	deleterious	0.03	0.35	NA	NA	0.81	disease	0.55	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.13	high_impact	0.08	0.8	40.09	8.36	0.32	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8498	8498	A	G	MI.1723	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	133	45	K	E	Aaa/Gaa	-5.89	0	0	possibly_damaging	0.87	neutral	0.39	neutral	1.76	neutral	1.22	neutral	-0.5	medium_impact	2.23	0.99	neutral	0.81	neutral	1.43	12.93	neutral	0.64287435	0.85	0.15	neutral	0.18	neutral	0.39	neutral	0.12	neutral	8	0.88	neutral	0.26	neutral	0	NA	0.65	deleterious	-1.54	low_impact	0.18	medium_impact	0.81	medium_impact	0.60	0.85	20.59	9.8	0.49	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11187	11187	T	G	MI.17230	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	428	143	L	R	cTg/cGg	0.29	0.02	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-3.12	deleterious	-4.46	medium_impact	2.94	0.55	damaging	0.09	damaging	4.11	23.70	deleterious	0.02	0.35	NA	NA	0.87	disease	0.66	disease	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	1.78	medium_impact	0.09	0.8	40.09	8.36	0.3	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11187	11187	T	C	MI.17231	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	428	143	L	P	cTg/cCg	0.29	0.02	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-3.82	deleterious	-5.24	high_impact	3.63	0.54	damaging	0.09	damaging	3.79	23.40	deleterious	0.01	0.35	NA	NA	0.83	disease	0.68	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	2.47	high_impact	0.05	0.8	40.09	8.36	0.31	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11189	11189	A	G	MI.17232	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	430	144	N	D	Aac/Gac	-2.94	0	0	benign	0.17	neutral	0.11	neutral	4.61	neutral	-0.59	deleterious	-3.6	medium_impact	2.32	0.77	neutral	0.17	damaging	3.72	23.30	deleterious	0.57	0.65	NA	NA	0.64	disease	0.45	neutral	0.49	neutral	0	0.87	neutral	0.47	deleterious	-3	neutral	0.79	deleterious	-0.07	medium_impact	-0.31	medium_impact	1.17	medium_impact	0.22	0.8	32.68	8.13	0.33	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11189	11189	A	C	MI.17233	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	430	144	N	H	Aac/Cac	-2.94	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.65	neutral	0.05	deleterious	-3.54	medium_impact	2.04	0.74	neutral	0.2	damaging	3.00	22.20	deleterious	0.36	0.5	NA	NA	0.67	disease	0.41	neutral	0.52	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-2.59	low_impact	-0.92	medium_impact	0.89	medium_impact	0.12	0.8	32.68	8.13	0.32	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11189	11189	A	T	MI.17234	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	430	144	N	Y	Aac/Tac	-2.94	0	0	probably_damaging	0.99	deleterious	0	neutral	4.61	neutral	-0.74	deleterious	-5.78	low_impact	1	0.73	neutral	0.1	damaging	3.65	23.20	deleterious	0.13	0.4	NA	NA	0.8	disease	0.5	neutral	0.67	disease	3	1	deleterious	0.01	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	-1.48	low_impact	-0.14	medium_impact	0.19	0.8	32.68	8.13	0.27	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11190	11190	A	C	MI.17235	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	431	144	N	T	aAc/aCc	6.75	0.99	0	probably_damaging	0.94	neutral	0.14	neutral	4.65	neutral	0.12	deleterious	-4.25	low_impact	1.43	0.75	neutral	0.29	neutral	3.38	23.00	deleterious	0.32	0.5	NA	NA	0.57	disease	0.19	neutral	0.45	neutral	1	0.97	neutral	0.1	neutral	-2	neutral	0.75	deleterious	-1.84	low_impact	-0.24	medium_impact	0.29	medium_impact	0.24	0.8	32.68	8.13	0.59	P	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11190	11190	A	T	MI.17236	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	431	144	N	I	aAc/aTc	6.75	0.99	0	probably_damaging	0.98	deleterious	0.02	neutral	4.57	neutral	-2.19	deleterious	-6.54	medium_impact	2.12	0.71	neutral	0.11	damaging	3.92	23.50	deleterious	0.14	0.4	NA	NA	0.8	disease	0.44	neutral	0.65	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-2.31	low_impact	-0.75	medium_impact	0.97	medium_impact	0.17	0.8	32.68	8.13	0.51	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11190	11190	A	G	MI.17237	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	431	144	N	S	aAc/aGc	6.75	0.99	0	possibly_damaging	0.81	neutral	0.36	neutral	4.7	neutral	0.72	deleterious	-3.44	neutral_impact	0.68	0.78	neutral	0.72	neutral	2.98	22.20	deleterious	0.49	0.55	NA	NA	0.38	neutral	0.23	neutral	0.2	neutral	6	0.83	neutral	0.28	neutral	-3	neutral	0.76	deleterious	-1.31	low_impact	0.06	medium_impact	-0.45	medium_impact	0.22	0.8	32.68	8.13	0.54	P	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11191	11191	C	G	MI.17238	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	432	144	N	K	aaC/aaG	2.37	0.97	0	probably_damaging	0.91	neutral	0.16	neutral	4.74	neutral	1.07	deleterious	-4.24	low_impact	0.96	0.78	neutral	0.19	damaging	3.88	23.50	deleterious	0.42	0.55	NA	NA	0.72	disease	0.28	neutral	0.51	disease	0	0.95	neutral	0.13	neutral	-2	neutral	0.82	deleterious	-1.66	low_impact	-0.2	medium_impact	-0.18	medium_impact	0.28	0.8	32.68	8.13	0.41	N	0.57	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11191	11191	C	A	MI.17239	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	432	144	N	K	aaC/aaA	2.37	0.97	0	probably_damaging	0.91	neutral	0.16	neutral	4.74	neutral	1.07	deleterious	-4.24	low_impact	0.96	0.78	neutral	0.19	damaging	4.36	24.10	deleterious	0.42	0.55	NA	NA	0.72	disease	0.28	neutral	0.51	disease	0	0.95	neutral	0.13	neutral	-2	neutral	0.82	deleterious	-1.66	low_impact	-0.2	medium_impact	-0.18	medium_impact	0.28	0.8	32.68	8.13	0.41	N	0.57	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8498	8498	A	C	MI.1724	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	133	45	K	Q	Aaa/Caa	-5.89	0	0	probably_damaging	0.95	neutral	0.38	neutral	1.56	neutral	-0.34	neutral	0.34	neutral_impact	0.08	0.99	neutral	0.97	neutral	1.13	11.40	neutral	0.50738370	0.85	0.16	neutral	0.05	neutral	0.27	neutral	0.04	neutral	9	0.95	neutral	0.22	neutral	-2	neutral	0.62	deleterious	-1.97	low_impact	0.17	medium_impact	-1.03	low_impact	0.70	0.85	20.59	9.8	0.53	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11192	11192	G	A	MI.17240	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	433	145	A	T	Gca/Aca	-4.09	0	0	possibly_damaging	0.48	deleterious	0	neutral	4.21	deleterious	-4.74	deleterious	-3.09	high_impact	3.92	0.52	damaging	0.39	neutral	2.37	18.60	deleterious	0.05	0.35	NA	NA	0.85	disease	0.7	disease	0.76	disease	5	1	deleterious	0.26	neutral	5	deleterious	0.37	neutral	-0.69	medium_impact	-1.48	low_impact	2.75	high_impact	0.72	0.85	46.19	9.28	0.47	N	0.82	polymorphism	1	0.35	.	.	.	.	.	.	COSM1138228	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11192	11192	G	T	MI.17241	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	433	145	A	S	Gca/Tca	-4.09	0	0	possibly_damaging	0.44	neutral	0.16	neutral	4.36	deleterious	-3.46	neutral	-2.31	medium_impact	2.55	0.52	damaging	0.51	neutral	1.86	15.36	deleterious	0.08	0.35	NA	NA	0.81	disease	0.65	disease	0.7	disease	4	0.82	neutral	0.36	neutral	0	NA	0.45	deleterious	-0.62	medium_impact	-0.2	medium_impact	1.4	medium_impact	0.48	0.8	46.19	9.28	0.4	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11192	11192	G	C	MI.17242	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	433	145	A	P	Gca/Cca	-4.09	0	0	benign	0.04	deleterious	0	neutral	4.2	deleterious	-6.18	deleterious	-3.86	high_impact	3.92	0.5	damaging	0.42	neutral	2.19	17.41	deleterious	0.03	0.35	NA	NA	0.87	disease	0.8	disease	0.82	disease	6	1	deleterious	0.48	deleterious	2	deleterious	0.68	deleterious	0.58	medium_impact	-1.48	low_impact	2.75	high_impact	0.44	0.8	46.19	9.28	0.5	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11193	11193	C	A	MI.17243	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	434	145	A	E	gCa/gAa	4.21	1	0	possibly_damaging	0.74	deleterious	0	neutral	4.23	deleterious	-3.91	deleterious	-3.86	high_impact	4.46	0.53	damaging	0.38	neutral	2.76	21.10	deleterious	0.02	0.35	NA	NA	0.88	disease	0.77	disease	0.8	disease	6	1	deleterious	0.13	neutral	5	deleterious	0.63	deleterious	-1.14	low_impact	-1.48	low_impact	3.29	high_impact	0.40	0.8	46.19	9.28	0.69	P	0.99	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11193	11193	C	T	MI.17244	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	434	145	A	V	gCa/gTa	4.21	1	0	benign	0.03	deleterious	0	neutral	4.21	deleterious	-5.31	deleterious	-3.09	high_impact	3.66	0.41	damaging	0.43	neutral	2.48	19.35	deleterious	0.05	0.35	NA	NA	0.82	disease	0.7	disease	0.75	disease	5	1	deleterious	0.49	deleterious	2	deleterious	0.29	neutral	0.7	medium_impact	-1.48	low_impact	2.5	high_impact	0.69	0.85	46.19	9.28	0.71	P	0.72	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11193	11193	C	G	MI.17245	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	434	145	A	G	gCa/gGa	4.21	1	0	possibly_damaging	0.51	deleterious	0	neutral	4.23	deleterious	-4.03	deleterious	-3.09	high_impact	3.92	0.47	damaging	0.5	neutral	2.07	16.66	deleterious	0.07	0.35	NA	NA	0.74	disease	0.67	disease	0.69	disease	4	1	deleterious	0.25	neutral	5	deleterious	0.44	deleterious	-0.73	medium_impact	-1.48	low_impact	2.75	high_impact	0.71	0.85	46.19	9.28	0.67	P	0.79	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11195	11195	G	A	MI.17246	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	436	146	G	S	Ggc/Agc	-8.24	0	0	benign	0.24	neutral	0.26	neutral	4.76	neutral	-1.14	deleterious	-4.47	low_impact	1.47	0.62	neutral	0.58	neutral	4.08	23.70	deleterious	0.06	0.35	NA	NA	0.85	disease	0.47	neutral	0.49	neutral	0	0.69	neutral	0.51	deleterious	-6	neutral	0.89	deleterious	-0.25	medium_impact	-0.05	medium_impact	0.33	medium_impact	0.65	0.8	17.86	20.57	0.38	N	0.39	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11195	11195	G	T	MI.17247	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	436	146	G	C	Ggc/Tgc	-8.24	0	0	probably_damaging	0.99	deleterious	0.03	neutral	4.44	deleterious	-4.06	deleterious	-6.82	medium_impact	3.36	0.57	damaging	0.27	damaging	4.09	23.70	deleterious	0.02	0.35	NA	NA	0.93	disease	0.67	disease	0.79	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.92	deleterious	-2.59	low_impact	-0.64	medium_impact	2.2	high_impact	0.25	0.8	17.86	20.57	0.3	N	0.87	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11195	11195	G	C	MI.17248	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	436	146	G	R	Ggc/Cgc	-8.24	0	0	probably_damaging	0.97	deleterious	0	neutral	4.43	neutral	-2.83	deleterious	-6.06	high_impact	4.16	0.58	damaging	0.29	neutral	3.91	23.50	deleterious	0.03	0.35	NA	NA	0.92	disease	0.76	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.94	deleterious	-2.14	low_impact	-1.48	low_impact	2.99	high_impact	0.50	0.8	17.86	20.57	0.43	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11196	11196	G	T	MI.17249	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	437	146	G	V	gGc/gTc	5.13	1	0	probably_damaging	0.97	deleterious	0.03	neutral	4.49	neutral	-1.85	deleterious	-6.83	medium_impact	3.19	0.57	damaging	0.35	neutral	3.71	23.30	deleterious	0.03	0.35	NA	NA	0.91	disease	0.67	disease	0.76	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.91	deleterious	-2.14	low_impact	-0.64	medium_impact	2.03	high_impact	0.26	0.8	17.86	20.57	0.55	P	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8499	8499	A	T	MI.1725	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	134	45	K	M	aAa/aTa	-7.28	0	0	probably_damaging	0.98	neutral	0.23	neutral	1.45	deleterious	-3.74	neutral	-1.24	low_impact	1.43	1	neutral	0.83	neutral	2.44	19.07	deleterious	0.44957237	0.85	0.38	neutral	0.08	neutral	0.27	neutral	0.04	neutral	9	0.99	deleterious	0.13	neutral	-2	neutral	0.67	deleterious	-2.36	low_impact	-0.01	medium_impact	0.13	medium_impact	0.63	0.85	20.59	9.8	0.58	P	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11196	11196	G	C	MI.17250	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	437	146	G	A	gGc/gCc	5.13	1	0	possibly_damaging	0.78	neutral	0.12	neutral	4.66	neutral	1.19	deleterious	-4.52	low_impact	1.88	0.63	neutral	0.44	neutral	3.07	22.40	deleterious	0.11	0.4	NA	NA	0.81	disease	0.6	disease	0.69	disease	4	0.92	neutral	0.17	neutral	-3	neutral	0.88	deleterious	-1.23	low_impact	-0.28	medium_impact	0.73	medium_impact	0.28	0.8	17.86	20.57	0.59	P	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11196	11196	G	A	MI.17251	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	437	146	G	D	gGc/gAc	5.13	1	0	probably_damaging	0.91	deleterious	0	neutral	4.42	deleterious	-3.91	deleterious	-5.29	high_impact	3.82	0.62	neutral	0.32	neutral	3.79	23.40	deleterious	0.02	0.35	NA	NA	0.91	disease	0.75	disease	0.8	disease	6	1	deleterious	0.05	neutral	6	deleterious	0.91	deleterious	-1.66	low_impact	-1.48	low_impact	2.65	high_impact	0.21	0.8	17.86	20.57	0.56	P	0.91	polymorphism	1	0.31	.	.	.	.	.	.	COSM488729	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11198	11198	A	C	MI.17252	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	439	147	T	P	Aca/Cca	-13.54	0	0	possibly_damaging	0.72	neutral	0.19	neutral	4.56	neutral	-2.73	deleterious	-2.67	medium_impact	2.74	0.67	neutral	0.4	neutral	0.64	8.43	deleterious	0.04	0.35	NA	NA	0.84	disease	0.69	disease	0.77	disease	5	0.85	neutral	0.24	neutral	0	NA	0.57	deleterious	-1.1	low_impact	-0.15	medium_impact	1.59	medium_impact	0.34	0.8	30.28	28.04	0.35	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11198	11198	A	T	MI.17253	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	439	147	T	S	Aca/Tca	-13.54	0	0	benign	0.04	neutral	0.4	neutral	4.59	neutral	-1.18	neutral	-1.46	neutral_impact	0.66	0.8	neutral	0.91	neutral	0.03	2.91	deleterious	0.25	0.45	NA	NA	0.49	neutral	0.34	neutral	0.44	neutral	1	0.57	neutral	0.68	deleterious	-6	neutral	0.17	neutral	0.58	medium_impact	0.1	medium_impact	-0.47	medium_impact	0.46	0.8	30.28	28.04	0.33	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11198	11198	A	G	MI.17254	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	439	147	T	A	Aca/Gca	-13.54	0	0	benign	0.22	neutral	0.48	neutral	4.62	neutral	-0.48	neutral	-1.43	medium_impact	2.19	0.72	neutral	0.7	neutral	0.23	5.00	deleterious	0.21	0.45	NA	NA	0.49	neutral	0.44	neutral	0.4	neutral	2	0.42	neutral	0.63	deleterious	-3	neutral	0.21	neutral	-0.2	medium_impact	0.18	medium_impact	1.04	medium_impact	0.46	0.8	30.28	28.04	0.37	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11199	11199	C	T	MI.17255	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	440	147	T	M	aCa/aTa	-1.32	0	0	benign	0.15	neutral	0.23	neutral	4.71	neutral	0.79	neutral	-0.68	neutral_impact	0.24	0.74	neutral	0.91	neutral	2.56	19.84	deleterious	0.12	0.4	NA	NA	0.42	neutral	0.35	neutral	0.18	neutral	6	0.73	neutral	0.54	deleterious	-6	neutral	0.63	deleterious	-0.01	medium_impact	-0.09	medium_impact	-0.89	medium_impact	0.65	0.8	30.28	28.04	0.44	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11199	11199	C	A	MI.17256	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	440	147	T	K	aCa/aAa	-1.32	0	0	possibly_damaging	0.44	neutral	0.28	neutral	4.57	neutral	-2.09	neutral	-2.27	low_impact	1.36	0.69	neutral	0.48	neutral	1.47	13.18	neutral	0.05	0.35	NA	NA	0.8	disease	0.59	disease	0.74	disease	5	0.68	neutral	0.42	neutral	-3	neutral	0.34	neutral	-0.62	medium_impact	-0.03	medium_impact	0.22	medium_impact	0.61	0.8	30.28	28.04	0.32	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11201	11201	T	A	MI.17257	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	442	148	Y	N	Tac/Aac	-11.93	0	0	probably_damaging	1	deleterious	0	neutral	4.55	neutral	-1.9	deleterious	-6.95	high_impact	3.56	0.57	damaging	0.11	damaging	4.00	23.60	deleterious	0.09	0.35	NA	NA	0.91	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.4	high_impact	0.20	0.8	47.06	9.27	0.33	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11201	11201	T	G	MI.17258	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	442	148	Y	D	Tac/Gac	-11.93	0	0	probably_damaging	1	deleterious	0	neutral	4.53	neutral	-2.08	deleterious	-7.72	high_impact	4.37	0.69	neutral	0.11	damaging	3.94	23.50	deleterious	0.03	0.35	NA	NA	0.9	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.2	high_impact	0.18	0.8	47.06	9.27	0.52	N	0.99	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11201	11201	T	C	MI.17259	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	442	148	Y	H	Tac/Cac	-11.93	0	0	probably_damaging	1	deleterious	0.01	neutral	4.51	neutral	-2.05	deleterious	-3.86	high_impact	4.37	0.57	damaging	0.09	damaging	3.51	23.10	deleterious	0.2	0.45	NA	NA	0.86	disease	0.75	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-0.92	medium_impact	3.2	high_impact	0.24	0.8	47.06	9.27	0.42	N	0.97	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8499	8499	A	C	MI.1726	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	134	45	K	T	aAa/aCa	-7.28	0	0	probably_damaging	0.92	neutral	0.47	neutral	1.52	neutral	-0.93	neutral	-1.28	neutral_impact	0.59	1	neutral	0.86	neutral	1.40	12.80	neutral	0.56962521	0.85	0.22	neutral	0.22	neutral	0.25	neutral	0.19	neutral	6	0.91	neutral	0.28	neutral	-2	neutral	0.65	deleterious	-1.76	low_impact	0.26	medium_impact	-0.59	medium_impact	0.67	0.85	20.59	9.8	0.47	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11202	11202	A	G	MI.17260	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	443	148	Y	C	tAc/tGc	5.83	1	0	probably_damaging	1	deleterious	0.01	neutral	4.5	deleterious	-4.8	deleterious	-6.95	high_impact	4.02	0.6	damaging	0.1	damaging	3.31	22.90	deleterious	0.05	0.35	NA	NA	0.91	disease	0.76	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-0.92	medium_impact	2.85	high_impact	0.10	0.8	47.06	9.27	0.57	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11202	11202	A	C	MI.17261	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	443	148	Y	S	tAc/tCc	5.83	1	0	probably_damaging	1	deleterious	0.01	neutral	4.57	neutral	-1.56	deleterious	-6.95	medium_impact	3.4	0.61	neutral	0.13	damaging	3.51	23.10	deleterious	0.07	0.35	NA	NA	0.89	disease	0.71	disease	0.77	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.88	deleterious	-3.54	low_impact	-0.92	medium_impact	2.24	high_impact	0.19	0.8	47.06	9.27	0.58	P	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11202	11202	A	T	MI.17262	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	443	148	Y	F	tAc/tTc	5.83	1	0	probably_damaging	1	deleterious	0.03	neutral	4.56	neutral	-2.78	deleterious	-3.09	medium_impact	2.92	0.57	damaging	0.13	damaging	3.18	22.70	deleterious	0.28	0.45	NA	NA	0.86	disease	0.66	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.87	deleterious	-3.54	low_impact	-0.64	medium_impact	1.76	medium_impact	0.41	0.8	47.06	9.27	0.54	P	0.79	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11204	11204	T	A	MI.17263	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	445	149	F	I	Ttc/Atc	-1.09	0	0.02	benign	0.38	deleterious	0.01	neutral	4.59	neutral	-2.46	deleterious	-4.62	medium_impact	2.67	0.72	neutral	0.65	neutral	2.60	20.20	deleterious	0.1	0.4	NA	NA	0.83	disease	0.61	disease	0.71	disease	4	0.99	deleterious	0.32	neutral	1	deleterious	0.26	neutral	-0.52	medium_impact	-0.92	medium_impact	1.52	medium_impact	0.51	0.8	46.19	9.05	0.37	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11204	11204	T	C	MI.17264	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	445	149	F	L	Ttc/Ctc	-1.09	0	0.02	benign	0.03	neutral	0.68	neutral	4.76	neutral	-1.75	deleterious	-4.62	low_impact	1.15	0.71	neutral	0.65	neutral	2.16	17.25	deleterious	0.19	0.45	NA	NA	0.57	disease	0.49	neutral	0.44	neutral	1	0.27	neutral	0.83	deleterious	-6	neutral	0.17	neutral	0.7	medium_impact	0.39	medium_impact	0.01	medium_impact	0.74	0.85	46.19	9.05	0.29	N	0.92	polymorphism	1	0.09	rs201803443	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11204	11204	T	G	MI.17265	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	445	149	F	V	Ttc/Gtc	-1.09	0	0.02	possibly_damaging	0.52	deleterious	0.01	neutral	4.6	neutral	-2.31	deleterious	-5.4	high_impact	3.51	0.7	neutral	0.56	neutral	2.24	17.76	deleterious	0.06	0.35	NA	NA	0.88	disease	0.67	disease	0.76	disease	5	0.99	deleterious	0.25	neutral	5	deleterious	0.28	neutral	-0.75	medium_impact	-0.92	medium_impact	2.35	high_impact	0.42	0.8	46.19	9.05	0.39	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11205	11205	T	A	MI.17266	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	446	149	F	Y	tTc/tAc	3.06	0.99	0	possibly_damaging	0.74	deleterious	0	neutral	4.87	neutral	-0.02	neutral	-2.31	medium_impact	3.37	0.72	neutral	0.53	neutral	2.43	18.98	deleterious	0.13	0.4	NA	NA	0.82	disease	0.65	disease	0.71	disease	4	1	deleterious	0.13	neutral	4	deleterious	0.38	neutral	-1.14	low_impact	-1.48	low_impact	2.21	high_impact	0.66	0.8	46.19	9.05	0.59	P	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11205	11205	T	G	MI.17267	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	446	149	F	C	tTc/tGc	3.06	0.99	0	probably_damaging	0.96	deleterious	0	neutral	4.52	deleterious	-5.03	deleterious	-6.17	high_impact	4.06	0.73	neutral	0.52	neutral	3.86	23.50	deleterious	0.03	0.35	NA	NA	0.91	disease	0.68	disease	0.77	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.75	deleterious	-2.01	low_impact	-1.48	low_impact	2.89	high_impact	0.34	0.8	46.19	9.05	0.53	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11205	11205	T	C	MI.17268	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	446	149	F	S	tTc/tCc	3.06	0.99	0	possibly_damaging	0.89	deleterious	0	neutral	4.55	neutral	-2.63	deleterious	-6.17	high_impact	3.71	0.73	neutral	0.6	neutral	2.54	19.73	deleterious	0.02	0.35	NA	NA	0.88	disease	0.66	disease	0.76	disease	5	1	deleterious	0.06	neutral	5	deleterious	0.44	deleterious	-1.57	low_impact	-1.48	low_impact	2.54	high_impact	0.43	0.8	46.19	9.05	0.56	P	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11206	11206	C	A	MI.17269	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	447	149	F	L	ttC/ttA	7.44	1	0	benign	0.03	neutral	0.68	neutral	4.76	neutral	-1.75	deleterious	-4.62	low_impact	1.15	0.71	neutral	0.65	neutral	2.69	20.70	deleterious	0.19	0.45	NA	NA	0.57	disease	0.49	neutral	0.44	neutral	1	0.27	neutral	0.83	deleterious	-6	neutral	0.17	neutral	0.7	medium_impact	0.39	medium_impact	0.01	medium_impact	0.74	0.85	46.19	9.05	0.51	N	0.92	polymorphism	1	0.09	rs28756874	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8500	8500	A	C	MI.1727	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	135	45	K	N	aaA/aaC	-6.35	0	0	probably_damaging	0.95	neutral	0.37	neutral	1.51	neutral	-1.11	neutral	-1.33	low_impact	1.78	0.99	neutral	0.8	neutral	1.80	14.97	neutral	0.78510221	0.85	0.27	neutral	0.19	neutral	0.36	neutral	0.11	neutral	8	0.95	neutral	0.21	neutral	-2	neutral	0.66	deleterious	-1.97	low_impact	0.16	medium_impact	0.43	medium_impact	0.79	0.85	20.59	9.8	0.49	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11206	11206	C	G	MI.17270	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	447	149	F	L	ttC/ttG	7.44	1	0	benign	0.03	neutral	0.68	neutral	4.76	neutral	-1.75	deleterious	-4.62	low_impact	1.15	0.71	neutral	0.65	neutral	2.36	18.54	deleterious	0.19	0.45	NA	NA	0.57	disease	0.49	neutral	0.44	neutral	1	0.27	neutral	0.83	deleterious	-6	neutral	0.17	neutral	0.7	medium_impact	0.39	medium_impact	0.01	medium_impact	0.74	0.85	46.19	9.05	0.53	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11207	11207	C	G	MI.17271	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	448	150	L	V	Cta/Gta	-4.78	0	0.01	probably_damaging	1	neutral	0.11	neutral	4.59	neutral	-1.15	neutral	-2.31	medium_impact	2.29	0.64	neutral	0.12	damaging	3.34	22.90	deleterious	0.17	0.45	NA	NA	0.61	disease	0.62	disease	0.59	disease	2	1	deleterious	0.06	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.31	medium_impact	1.14	medium_impact	0.52	0.8	46.84	9.18	0.29	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11207	11207	C	A	MI.17272	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	448	150	L	M	Cta/Ata	-4.78	0	0.01	probably_damaging	1	neutral	0.3	neutral	4.51	neutral	-2.43	neutral	-1.54	low_impact	1.52	0.75	neutral	0.28	neutral	3.64	23.20	deleterious	0.16	0.45	NA	NA	0.35	neutral	0.4	neutral	0.16	neutral	7	1	deleterious	0.15	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	0	medium_impact	0.38	medium_impact	0.40	0.8	46.84	9.18	0.35	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11208	11208	T	A	MI.17273	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	449	150	L	Q	cTa/cAa	-2.01	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-5.08	deleterious	-4.63	high_impact	4.04	0.61	neutral	0.11	damaging	4.01	23.60	deleterious	0.01	0.35	NA	NA	0.82	disease	0.63	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.33	0.8	46.84	9.18	0.35	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11208	11208	T	G	MI.17274	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	449	150	L	R	cTa/cGa	-2.01	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-4.89	deleterious	-4.63	high_impact	4.04	0.61	neutral	0.1	damaging	4.13	23.80	deleterious	0.01	0.35	NA	NA	0.89	disease	0.74	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.20	0.8	46.84	9.18	0.37	N	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11208	11208	T	C	MI.17275	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	449	150	L	P	cTa/cCa	-2.01	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-5.46	deleterious	-5.4	high_impact	4.04	0.57	damaging	0.1	damaging	3.85	23.40	deleterious	0.01	0.35	NA	NA	0.85	disease	0.74	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.45	0.8	46.84	9.18	0.35	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11210	11210	T	C	MI.17276	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	451	151	F	L	Ttc/Ctc	-0.86	0.01	0	benign	0.08	neutral	0.16	neutral	5.08	neutral	2.14	deleterious	-4.62	low_impact	1.64	0.66	neutral	0.3	neutral	3.93	23.50	deleterious	0.21	0.45	NA	NA	0.81	disease	0.53	disease	0.49	neutral	0	0.82	neutral	0.54	deleterious	-6	neutral	0.79	deleterious	0.28	medium_impact	-0.2	medium_impact	0.5	medium_impact	0.64	0.8	47.28	9.39	0.27	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11210	11210	T	G	MI.17277	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	451	151	F	V	Ttc/Gtc	-0.86	0.01	0	possibly_damaging	0.74	deleterious	0.02	neutral	4.68	neutral	0.31	deleterious	-5.39	medium_impact	2.68	0.72	neutral	0.15	damaging	3.97	23.60	deleterious	0.11	0.4	NA	NA	0.89	disease	0.67	disease	0.75	disease	5	0.98	deleterious	0.14	neutral	4	deleterious	0.83	deleterious	-1.14	low_impact	-0.75	medium_impact	1.53	medium_impact	0.42	0.8	47.28	9.39	0.33	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11210	11210	T	A	MI.17278	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	451	151	F	I	Ttc/Atc	-0.86	0.01	0	possibly_damaging	0.74	neutral	0.05	neutral	4.66	neutral	0.12	deleterious	-4.62	medium_impact	2.04	0.72	neutral	0.16	damaging	4.32	24.00	deleterious	0.14	0.4	NA	NA	0.81	disease	0.61	disease	0.53	disease	1	0.96	neutral	0.16	neutral	0	NA	0.82	deleterious	-1.14	low_impact	-0.52	medium_impact	0.89	medium_impact	0.46	0.8	47.28	9.39	0.37	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11211	11211	T	G	MI.17279	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	452	151	F	C	tTc/tGc	7.44	1	0	probably_damaging	0.98	deleterious	0.01	neutral	4.5	deleterious	-3.34	deleterious	-6.16	high_impact	4.16	0.73	neutral	0.12	damaging	4.01	23.60	deleterious	0.03	0.35	NA	NA	0.9	disease	0.66	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-2.31	low_impact	-0.92	medium_impact	2.99	high_impact	0.30	0.8	47.28	9.39	0.58	P	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8500	8500	A	T	MI.1728	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	135	45	K	N	aaA/aaT	-6.35	0	0	probably_damaging	0.95	neutral	0.37	neutral	1.51	neutral	-1.11	neutral	-1.33	low_impact	1.78	0.99	neutral	0.8	neutral	1.88	15.44	deleterious	0.78510221	0.85	0.27	neutral	0.19	neutral	0.36	neutral	0.11	neutral	8	0.95	neutral	0.21	neutral	-2	neutral	0.66	deleterious	-1.97	low_impact	0.16	medium_impact	0.43	medium_impact	0.79	0.85	20.59	9.8	0.49	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11211	11211	T	A	MI.17280	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	452	151	F	Y	tTc/tAc	7.44	1	0	possibly_damaging	0.89	deleterious	0	neutral	4.51	neutral	-2.55	neutral	-2.31	high_impact	3.81	0.73	neutral	0.13	damaging	4.37	24.10	deleterious	0.13	0.4	NA	NA	0.83	disease	0.6	disease	0.71	disease	4	1	deleterious	0.06	neutral	5	deleterious	0.83	deleterious	-1.57	low_impact	-1.48	low_impact	2.64	high_impact	0.50	0.8	47.28	9.39	0.63	P	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11211	11211	T	C	MI.17281	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	452	151	F	S	tTc/tCc	7.44	1	0	probably_damaging	0.96	deleterious	0	neutral	4.56	neutral	-1.22	deleterious	-6.16	high_impact	3.81	0.73	neutral	0.16	damaging	4.24	23.90	deleterious	0.04	0.35	NA	NA	0.88	disease	0.64	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.01	low_impact	-1.48	low_impact	2.64	high_impact	0.46	0.8	47.28	9.39	0.62	P	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11212	11212	C	A	MI.17282	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	453	151	F	L	ttC/ttA	7.44	1	0	benign	0.08	neutral	0.16	neutral	5.08	neutral	2.14	deleterious	-4.62	low_impact	1.64	0.66	neutral	0.3	neutral	4.48	24.20	deleterious	0.21	0.45	NA	NA	0.81	disease	0.53	disease	0.49	neutral	0	0.82	neutral	0.54	deleterious	-6	neutral	0.79	deleterious	0.28	medium_impact	-0.2	medium_impact	0.5	medium_impact	0.64	0.8	47.28	9.39	0.59	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11212	11212	C	G	MI.17283	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	453	151	F	L	ttC/ttG	7.44	1	0	benign	0.08	neutral	0.16	neutral	5.08	neutral	2.14	deleterious	-4.62	low_impact	1.64	0.66	neutral	0.3	neutral	4.26	23.90	deleterious	0.21	0.45	NA	NA	0.81	disease	0.53	disease	0.49	neutral	0	0.82	neutral	0.54	deleterious	-6	neutral	0.79	deleterious	0.28	medium_impact	-0.2	medium_impact	0.5	medium_impact	0.64	0.8	47.28	9.39	0.58	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11213	11213	T	G	MI.17284	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	454	152	Y	D	Tac/Gac	-4.09	0	0	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-4.97	deleterious	-7.72	high_impact	4.53	0.67	neutral	0.12	damaging	3.80	23.40	deleterious	0.02	0.35	NA	NA	0.9	disease	0.81	disease	0.81	disease	6	1	deleterious	0	deleterious	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.36	0.8	47.06	9.31	0.54	N	0.99	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11213	11213	T	A	MI.17285	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	454	152	Y	N	Tac/Aac	-4.09	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-4.42	deleterious	-6.95	high_impact	4.53	0.63	neutral	0.11	damaging	3.89	23.50	deleterious	0.03	0.35	NA	NA	0.9	disease	0.74	disease	0.79	disease	6	1	deleterious	0	deleterious	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.44	0.8	47.06	9.31	0.46	N	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11213	11213	T	C	MI.17286	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	454	152	Y	H	Tac/Cac	-4.09	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-4.7	deleterious	-3.86	high_impact	4.53	0.61	neutral	0.1	damaging	3.45	23.00	deleterious	0.09	0.35	NA	NA	0.87	disease	0.8	disease	0.8	disease	6	1	deleterious	0	deleterious	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.42	0.8	47.06	9.31	0.57	P	0.97	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11214	11214	A	G	MI.17287	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	455	152	Y	C	tAc/tGc	5.6	1	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-3.66	deleterious	-6.95	high_impact	4.53	0.65	neutral	0.08	damaging	3.46	23.00	deleterious	0.03	0.35	NA	NA	0.9	disease	0.77	disease	0.8	disease	6	1	deleterious	0	deleterious	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.26	0.8	47.06	9.31	0.66	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11214	11214	A	T	MI.17288	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	455	152	Y	F	tAc/tTc	5.6	1	0	probably_damaging	1	deleterious	0.04	neutral	4.48	neutral	-1.91	deleterious	-3.09	medium_impact	2.98	0.64	neutral	0.12	damaging	3.42	23.00	deleterious	0.18	0.45	NA	NA	0.86	disease	0.67	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-0.57	medium_impact	1.82	medium_impact	0.66	0.8	47.06	9.31	0.57	P	0.79	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11214	11214	A	C	MI.17289	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	455	152	Y	S	tAc/tCc	5.6	1	0	probably_damaging	1	deleterious	0	neutral	4.49	neutral	-2.84	deleterious	-6.95	high_impact	4.53	0.65	neutral	0.12	damaging	3.63	23.20	deleterious	0.03	0.35	NA	NA	0.88	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.47	0.8	47.06	9.31	0.62	P	0.95	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8501	8501	A	G	MI.1729	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	136	46	N	D	Aat/Gat	-6.35	0	0	possibly_damaging	0.87	neutral	0.27	neutral	1.79	neutral	-0.67	neutral	-1.31	low_impact	0.98	1	neutral	0.54	neutral	1.58	13.74	neutral	0.76071314	0.85	0.27	neutral	0.08	neutral	0.32	neutral	0.05	neutral	9	0.9	neutral	0.2	neutral	-3	neutral	0.60	deleterious	-1.54	low_impact	0.05	medium_impact	-0.26	medium_impact	0.68	0.85	NA	NA	0.53	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11216	11216	A	T	MI.17290	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	457	153	T	S	Acc/Tcc	-3.17	0	0	probably_damaging	1	deleterious	0	neutral	4.56	neutral	-1.76	deleterious	-3.09	high_impact	3.55	0.61	neutral	0.15	damaging	3.13	22.60	deleterious	0.29	0.45	NA	NA	0.76	disease	0.66	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.39	high_impact	0.73	0.85	47.49	9.33	0.37	N	0.87	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11216	11216	A	C	MI.17291	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	457	153	T	P	Acc/Ccc	-3.17	0	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-4.93	deleterious	-4.63	high_impact	4.53	0.59	damaging	0.12	damaging	3.36	22.90	deleterious	0.04	0.35	NA	NA	0.85	disease	0.79	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.45	0.8	47.49	9.33	0.53	N	0.97	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11216	11216	A	G	MI.17292	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	457	153	T	A	Acc/Gcc	-3.17	0	0	probably_damaging	1	deleterious	0.04	neutral	4.5	neutral	-1.43	deleterious	-3.86	high_impact	3.72	0.58	damaging	0.17	damaging	3.30	22.90	deleterious	0.12	0.4	NA	NA	0.7	disease	0.69	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.57	medium_impact	2.55	high_impact	0.33	0.8	47.49	9.33	0.31	N	0.69	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11217	11217	C	G	MI.17293	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	458	153	T	S	aCc/aGc	4.67	1	0	probably_damaging	1	deleterious	0	neutral	4.56	neutral	-1.76	deleterious	-3.09	high_impact	3.55	0.61	neutral	0.15	damaging	3.47	23.00	deleterious	0.29	0.45	NA	NA	0.76	disease	0.66	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.39	high_impact	0.73	0.85	47.49	9.33	0.55	P	0.87	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11217	11217	C	T	MI.17294	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	458	153	T	I	aCc/aTc	4.67	1	0	probably_damaging	1	deleterious	0.02	neutral	4.42	deleterious	-3.32	deleterious	-4.63	high_impact	3.98	0.58	damaging	0.13	damaging	3.92	23.50	deleterious	0.06	0.35	NA	NA	0.88	disease	0.67	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-0.75	medium_impact	2.81	high_impact	0.62	0.8	47.49	9.33	0.54	P	0.95	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11217	11217	C	A	MI.17295	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	458	153	T	N	aCc/aAc	4.67	1	0	probably_damaging	1	deleterious	0	neutral	4.6	neutral	-0.5	deleterious	-3.86	high_impact	3.98	0.55	damaging	0.14	damaging	3.60	23.20	deleterious	0.2	0.45	NA	NA	0.87	disease	0.68	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.81	high_impact	0.54	0.8	47.49	9.33	0.56	P	0.93	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11219	11219	C	A	MI.17296	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	460	154	L	M	Cta/Ata	-13.31	0	0	probably_damaging	1	neutral	0.07	neutral	4.56	neutral	-2.73	neutral	-1.53	medium_impact	2.09	0.59	damaging	0.21	damaging	3.68	23.30	deleterious	0.28	0.45	NA	NA	0.53	disease	0.41	neutral	0.45	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.43	medium_impact	0.94	medium_impact	0.68	0.85	46.84	9.05	0.34	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11219	11219	C	G	MI.17297	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	460	154	L	V	Cta/Gta	-13.31	0	0	probably_damaging	1	neutral	0.17	neutral	4.62	neutral	-1.36	neutral	-2.29	medium_impact	2.07	0.57	damaging	0.11	damaging	3.36	22.90	deleterious	0.26	0.45	NA	NA	0.59	disease	0.56	disease	0.48	neutral	0	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.18	medium_impact	0.92	medium_impact	0.61	0.8	46.84	9.05	0.28	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11220	11220	T	G	MI.17298	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	461	154	L	R	cTa/cGa	-1.55	0	0	probably_damaging	1	deleterious	0	neutral	4.71	neutral	-0.78	deleterious	-4.62	high_impact	3.9	0.57	damaging	0.09	damaging	4.10	23.70	deleterious	0.05	0.35	NA	NA	0.9	disease	0.74	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	2.73	high_impact	0.18	0.8	46.84	9.05	0.35	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11220	11220	T	C	MI.17299	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	461	154	L	P	cTa/cCa	-1.55	0	0	probably_damaging	1	deleterious	0.01	neutral	4.53	deleterious	-5.06	deleterious	-5.38	high_impact	4.25	0.53	damaging	0.11	damaging	3.83	23.40	deleterious	0.04	0.35	NA	NA	0.82	disease	0.75	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-0.92	medium_impact	3.08	high_impact	0.25	0.8	46.84	9.05	0.39	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8606	8606	C	T	MI.173	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	80	27	P	L	cCc/cTc	5.45	1	0	probably_damaging	1	neutral	0.67	neutral	4.57	neutral	1.84	deleterious	-8.3	medium_impact	2.47	0.65	neutral	0.49	neutral	4.22	23.90	deleterious	0.4	0.65	0.27	neutral	0.84	disease	0.54	disease	0.67	disease	3	1	deleterious	0.34	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.47	medium_impact	1.02	medium_impact	0.81	0.9	48.23	8.81	0.43	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8501	8501	A	T	MI.1730	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	136	46	N	Y	Aat/Tat	-6.35	0	0	probably_damaging	0.98	neutral	0.1	neutral	1.5	deleterious	-3.03	neutral	-2.36	low_impact	1.45	0.99	neutral	0.71	neutral	3.45	23.00	deleterious	0.61638548	0.85	0.61	disease	0.12	neutral	0.24	neutral	0.1	neutral	8	0.99	deleterious	0.06	neutral	-2	neutral	0.68	deleterious	-2.36	low_impact	-0.25	medium_impact	0.15	medium_impact	0.70	0.85	NA	NA	0.56	P	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11220	11220	T	A	MI.17300	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	461	154	L	Q	cTa/cAa	-1.55	0	0	probably_damaging	1	deleterious	0	neutral	4.58	deleterious	-3.2	deleterious	-4.62	medium_impact	3.21	0.54	damaging	0.1	damaging	3.99	23.60	deleterious	0.06	0.35	NA	NA	0.8	disease	0.64	disease	0.7	disease	4	1	deleterious	0	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.05	high_impact	0.25	0.8	46.84	9.05	0.29	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11222	11222	G	T	MI.17301	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	463	155	V	L	Gta/Tta	-0.63	0	0	benign	0.02	neutral	0.84	neutral	4.69	neutral	-0.67	neutral	-0.47	neutral_impact	0.7	0.76	neutral	0.86	neutral	2.35	18.49	deleterious	0.23	0.45	NA	NA	0.48	neutral	0.3	neutral	0.3	neutral	4	0.11	neutral	0.91	deleterious	-6	neutral	0.69	deleterious	0.87	medium_impact	0.61	medium_impact	-0.43	medium_impact	0.38	0.8	11.11	10.8	0.25	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11222	11222	G	C	MI.17302	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	463	155	V	L	Gta/Cta	-0.63	0	0	benign	0.02	neutral	0.84	neutral	4.69	neutral	-0.67	neutral	-0.47	neutral_impact	0.7	0.76	neutral	0.86	neutral	2.19	17.44	deleterious	0.23	0.45	NA	NA	0.48	neutral	0.3	neutral	0.3	neutral	4	0.11	neutral	0.91	deleterious	-6	neutral	0.69	deleterious	0.87	medium_impact	0.61	medium_impact	-0.43	medium_impact	0.38	0.8	11.11	10.8	0.25	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11222	11222	G	A	MI.17303	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	463	155	V	M	Gta/Ata	-0.63	0	0	possibly_damaging	0.76	neutral	0.26	neutral	4.47	deleterious	-3.44	neutral	-0.34	neutral_impact	0.8	0.72	neutral	0.94	neutral	2.27	17.95	deleterious	0.2	0.45	NA	NA	0.35	neutral	0.33	neutral	0.14	neutral	7	0.83	neutral	0.25	neutral	-3	neutral	0.67	deleterious	-1.19	low_impact	-0.05	medium_impact	-0.33	medium_impact	0.54	0.8	11.11	10.8	0.46	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11223	11223	T	G	MI.17304	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	464	155	V	G	gTa/gGa	-2.71	0	0	benign	0.27	neutral	0.34	neutral	4.46	neutral	-2.85	deleterious	-2.81	low_impact	1.24	0.72	neutral	0.48	neutral	3.77	23.40	deleterious	0.05	0.35	NA	NA	0.6	disease	0.59	disease	0.73	disease	5	0.59	neutral	0.54	deleterious	-6	neutral	0.73	deleterious	-0.31	medium_impact	0.04	medium_impact	0.1	medium_impact	0.22	0.8	11.11	10.8	0.31	N	0.74	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11223	11223	T	C	MI.17305	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	464	155	V	A	gTa/gCa	-2.71	0	0	benign	0.01	neutral	0.59	neutral	4.53	neutral	-1.11	neutral	-0.53	neutral_impact	-0.12	0.69	neutral	0.99	neutral	0.80	9.45	deleterious	0.16	0.45	NA	NA	0.08	neutral	0.32	neutral	0.2	neutral	6	0.39	neutral	0.79	deleterious	-6	neutral	0.65	deleterious	1.16	medium_impact	0.29	medium_impact	-1.25	low_impact	0.11	0.8	11.11	10.8	0.4	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11223	11223	T	A	MI.17306	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	464	155	V	E	gTa/gAa	-2.71	0	0	benign	0.37	neutral	0.27	neutral	4.43	deleterious	-5.12	neutral	-2.46	medium_impact	2.9	0.69	neutral	0.45	neutral	4.84	24.80	deleterious	0.02	0.35	NA	NA	0.81	disease	0.62	disease	0.8	disease	6	0.68	neutral	0.45	neutral	-3	neutral	0.79	deleterious	-0.5	medium_impact	-0.04	medium_impact	1.74	medium_impact	0.14	0.8	11.11	10.8	0.36	N	0.86	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11225	11225	G	C	MI.17307	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	466	156	G	R	Ggc/Cgc	-3.17	0	0	probably_damaging	1	deleterious	0.02	neutral	4.06	deleterious	-7.56	deleterious	-5.9	high_impact	3.85	0.68	neutral	0.07	damaging	3.83	23.40	deleterious	0.02	0.35	NA	NA	0.93	disease	0.8	disease	0.89	disease	8	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-0.75	medium_impact	2.68	high_impact	0.60	0.8	47.06	9.09	0.38	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11225	11225	G	A	MI.17308	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	466	156	G	S	Ggc/Agc	-3.17	0	0	probably_damaging	1	neutral	0.42	neutral	4.49	deleterious	-3.23	deleterious	-4.35	low_impact	0.82	0.7	neutral	0.31	neutral	4.10	23.70	deleterious	0.04	0.35	NA	NA	0.54	disease	0.46	neutral	0.46	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	0.12	medium_impact	-0.32	medium_impact	0.51	0.8	47.06	9.09	0.33	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	COSM1138230	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11225	11225	G	T	MI.17309	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	466	156	G	C	Ggc/Tgc	-3.17	0	0	probably_damaging	1	neutral	0.17	neutral	4.08	deleterious	-7.98	deleterious	-6.6	medium_impact	3.15	0.74	neutral	0.08	damaging	4.02	23.60	deleterious	0.02	0.35	NA	NA	0.91	disease	0.69	disease	0.77	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.18	medium_impact	1.99	medium_impact	0.23	0.8	47.06	9.09	0.28	N	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8501	8501	A	C	MI.1731	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	136	46	N	H	Aat/Cat	-6.35	0	0	probably_damaging	0.98	neutral	0.16	neutral	1.52	neutral	-2.08	neutral	-1.5	low_impact	0.82	1	neutral	0.59	neutral	1.75	14.72	neutral	0.75672260	0.85	0.47	neutral	0.07	neutral	0.24	neutral	0.05	neutral	9	0.99	deleterious	0.09	neutral	-2	neutral	0.64	deleterious	-2.36	low_impact	-0.12	medium_impact	-0.4	medium_impact	0.76	0.85	NA	NA	0.57	P	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11226	11226	G	T	MI.17310	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	467	156	G	V	gGc/gTc	5.83	1	0	probably_damaging	1	neutral	0.13	neutral	4.07	deleterious	-6.68	deleterious	-6.6	medium_impact	2.6	0.67	neutral	0.08	damaging	3.67	23.30	deleterious	0.02	0.35	NA	NA	0.87	disease	0.7	disease	0.6	disease	2	1	deleterious	0.07	neutral	1	deleterious	0.87	deleterious	-3.54	low_impact	-0.26	medium_impact	1.45	medium_impact	0.18	0.8	47.06	9.09	0.45	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11226	11226	G	A	MI.17311	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	467	156	G	D	gGc/gAc	5.83	1	0	probably_damaging	1	deleterious	0.02	neutral	4.05	deleterious	-7.62	deleterious	-5.2	high_impact	3.85	0.7	neutral	0.08	damaging	3.78	23.40	deleterious	0.01	0.35	NA	NA	0.91	disease	0.79	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-0.75	medium_impact	2.68	high_impact	0.10	0.8	47.06	9.09	0.55	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11226	11226	G	C	MI.17312	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	467	156	G	A	gGc/gCc	5.83	1	0	probably_damaging	1	neutral	0.63	neutral	4.26	deleterious	-3.17	deleterious	-4.25	low_impact	0.88	0.71	neutral	0.21	damaging	3.00	22.20	deleterious	0.06	0.35	NA	NA	0.43	neutral	0.46	neutral	0.19	neutral	6	1	deleterious	0.32	neutral	-2	neutral	0.77	deleterious	-3.54	low_impact	0.33	medium_impact	-0.26	medium_impact	0.47	0.8	47.06	9.09	0.49	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11228	11228	T	C	MI.17313	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	469	157	S	P	Tcc/Ccc	-2.94	0	0	probably_damaging	1	deleterious	0	neutral	3.77	deleterious	-6.27	deleterious	-3.86	high_impact	4.17	0.52	damaging	0.47	neutral	3.89	23.50	deleterious	0.03	0.35	NA	NA	0.85	disease	0.8	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3	high_impact	0.24	0.8	47.49	9.31	0.52	N	0.99	polymorphism	1	0.42	.	.	.	.	.	.	COSM1138231	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11228	11228	T	A	MI.17314	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	469	157	S	T	Tcc/Acc	-2.94	0	0	probably_damaging	1	deleterious	0.01	neutral	3.79	deleterious	-5.14	neutral	-2.32	high_impact	3.54	0.58	damaging	0.42	neutral	3.73	23.30	deleterious	0.19	0.45	NA	NA	0.69	disease	0.69	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-0.92	medium_impact	2.38	high_impact	0.59	0.8	47.49	9.31	0.39	N	0.73	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11228	11228	T	G	MI.17315	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	469	157	S	A	Tcc/Gcc	-2.94	0	0	probably_damaging	1	deleterious	0.01	neutral	3.86	deleterious	-3.42	neutral	-2.32	medium_impact	3.48	0.53	damaging	0.72	neutral	3.62	23.20	deleterious	0.19	0.45	NA	NA	0.59	disease	0.54	disease	0.44	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	2.32	high_impact	0.31	0.8	47.49	9.31	0.46	N	0.51	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11229	11229	C	T	MI.17316	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	470	157	S	F	tCc/tTc	7.44	1	0	probably_damaging	1	deleterious	0	neutral	3.76	deleterious	-7.72	deleterious	-4.63	high_impact	4.51	0.48	damaging	0.44	neutral	4.20	23.90	deleterious	0.05	0.35	NA	NA	0.91	disease	0.72	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.34	high_impact	0.10	0.8	47.49	9.31	0.57	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11229	11229	C	G	MI.17317	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	470	157	S	C	tCc/tGc	7.44	1	0	probably_damaging	1	deleterious	0	neutral	3.76	deleterious	-7.76	deleterious	-3.86	high_impact	4.51	0.56	damaging	0.4	neutral	3.55	23.10	deleterious	0.06	0.35	NA	NA	0.82	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.34	high_impact	0.21	0.8	47.49	9.31	0.53	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11229	11229	C	A	MI.17318	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	470	157	S	Y	tCc/tAc	7.44	1	0	probably_damaging	1	deleterious	0	neutral	3.76	deleterious	-7.44	deleterious	-4.63	high_impact	4.51	0.54	damaging	0.37	neutral	4.01	23.60	deleterious	0.04	0.35	NA	NA	0.88	disease	0.73	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.34	high_impact	0.16	0.8	47.49	9.31	0.54	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11231	11231	C	T	MI.17319	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	472	158	L	F	Ctt/Ttt	-13.77	0	0	probably_damaging	0.98	neutral	0.12	neutral	4.53	neutral	-1.26	deleterious	-3.01	medium_impact	2.7	0.66	neutral	0.15	damaging	3.91	23.50	deleterious	0.2	0.45	NA	NA	0.71	disease	0.57	disease	0.61	disease	2	0.99	deleterious	0.07	neutral	1	deleterious	0.82	deleterious	-2.31	low_impact	-0.28	medium_impact	1.55	medium_impact	0.63	0.8	18.3	22.31	0.23	N	0.73	polymorphism	1	0.08	rs28592011	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8502	8502	A	C	MI.1732	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	137	46	N	T	aAt/aCt	-0.1	0	0	probably_damaging	0.92	neutral	0.35	neutral	1.56	neutral	-1.24	neutral	-0.43	neutral_impact	-0.16	1	neutral	0.96	neutral	1.14	11.42	neutral	0.82750062	0.90	0.34	neutral	0.06	neutral	0.18	neutral	0.05	neutral	9	0.92	neutral	0.22	neutral	-2	neutral	0.61	deleterious	-1.76	low_impact	0.14	medium_impact	-1.24	low_impact	0.70	0.85	NA	NA	0.57	P	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11231	11231	C	G	MI.17320	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	472	158	L	V	Ctt/Gtt	-13.77	0	0	benign	0.3	neutral	0.08	neutral	4.6	neutral	-0.86	neutral	-2.16	medium_impact	2.57	0.64	neutral	0.26	damaging	3.39	23.00	deleterious	0.3	0.45	NA	NA	0.56	disease	0.42	neutral	0.45	neutral	1	0.91	neutral	0.39	neutral	-3	neutral	0.81	deleterious	-0.37	medium_impact	-0.39	medium_impact	1.42	medium_impact	0.45	0.8	18.3	22.31	0.37	N	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11231	11231	C	A	MI.17321	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	472	158	L	I	Ctt/Att	-13.77	0	0	possibly_damaging	0.76	neutral	0.07	neutral	4.61	neutral	-1.69	neutral	-1.39	medium_impact	2.67	0.72	neutral	0.83	neutral	3.00	22.20	deleterious	0.36	0.5	NA	NA	0.56	disease	0.39	neutral	0.45	neutral	1	0.95	neutral	0.16	neutral	0	NA	0.80	deleterious	-1.19	low_impact	-0.43	medium_impact	1.52	medium_impact	0.57	0.8	18.3	22.31	0.49	N	0.08	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11232	11232	T	C	MI.17322	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	473	158	L	P	cTt/cCt	-0.4	0	0	probably_damaging	1	deleterious	0	neutral	4.41	deleterious	-5.44	deleterious	-5.32	high_impact	4.39	0.59	damaging	0.1	damaging	3.76	23.30	deleterious	0.04	0.35	NA	NA	0.81	disease	0.76	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.22	high_impact	0.19	0.8	18.3	22.31	0.47	N	0.86	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	T11232C	CPEO	-	+	Reported	3	.	P	P	damaging
chrM	11232	11232	T	G	MI.17323	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	473	158	L	R	cTt/cGt	-0.4	0	0	probably_damaging	0.99	deleterious	0	neutral	4.42	deleterious	-4.87	deleterious	-4.59	high_impact	4.39	0.65	neutral	0.1	damaging	4.14	23.80	deleterious	0.04	0.35	NA	NA	0.89	disease	0.76	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.59	low_impact	-1.48	low_impact	3.22	high_impact	0.18	0.8	18.3	22.31	0.52	N	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11232	11232	T	A	MI.17324	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	473	158	L	H	cTt/cAt	-0.4	0	0	probably_damaging	1	deleterious	0	neutral	4.41	deleterious	-5.39	deleterious	-5.32	high_impact	4.39	0.62	neutral	0.11	damaging	4.01	23.60	deleterious	0.06	0.35	NA	NA	0.81	disease	0.72	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.22	high_impact	0.22	0.8	18.3	22.31	0.44	N	0.82	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11234	11234	C	A	MI.17325	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	475	159	P	T	Ccc/Acc	-20	0	0	probably_damaging	1	deleterious	0	neutral	4.59	neutral	0.57	deleterious	-6.18	high_impact	4.07	0.52	damaging	0.09	damaging	3.62	23.20	deleterious	0.14	0.4	NA	NA	0.81	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.9	high_impact	0.56	0.8	47.06	9.43	0.34	N	0.89	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11234	11234	C	G	MI.17326	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	475	159	P	A	Ccc/Gcc	-20	0	0	probably_damaging	1	deleterious	0	neutral	4.62	neutral	2.39	deleterious	-6.18	medium_impact	3.31	0.52	damaging	0.16	damaging	3.03	22.30	deleterious	0.14	0.4	NA	NA	0.71	disease	0.65	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.15	high_impact	0.63	0.8	47.06	9.43	0.36	N	0.77	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11234	11234	C	T	MI.17327	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	475	159	P	S	Ccc/Tcc	-20	0	0	probably_damaging	1	deleterious	0	neutral	4.57	neutral	0.93	deleterious	-6.18	high_impact	3.86	0.5	damaging	0.11	damaging	3.82	23.40	deleterious	0.15	0.45	NA	NA	0.84	disease	0.66	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.69	high_impact	0.17	0.8	47.06	9.43	0.37	N	0.71	polymorphism	1	0.20	.	.	.	.	.	.	COSM6716721	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11235	11235	C	T	MI.17328	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	476	159	P	L	cCc/cTc	5.6	1	0	probably_damaging	1	deleterious	0.01	neutral	4.82	neutral	3.18	deleterious	-7.72	medium_impact	2.36	0.49	damaging	0.07	damaging	4.34	24.00	deleterious	0.11	0.4	NA	NA	0.92	disease	0.63	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.86	deleterious	-3.54	low_impact	-0.92	medium_impact	1.21	medium_impact	0.52	0.8	47.06	9.43	0.53	P	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11235	11235	C	A	MI.17329	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	476	159	P	H	cCc/cAc	5.6	1	0	probably_damaging	1	deleterious	0	neutral	4.54	neutral	-1.64	deleterious	-6.94	high_impact	4.41	0.51	damaging	0.08	damaging	3.94	23.50	deleterious	0.09	0.35	NA	NA	0.89	disease	0.76	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.24	high_impact	0.30	0.8	47.06	9.43	0.66	P	0.70	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8502	8502	A	T	MI.1733	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	137	46	N	I	aAt/aTt	-0.1	0	0	probably_damaging	0.98	neutral	0.17	neutral	1.5	neutral	-2.69	neutral	-2.46	low_impact	1.24	0.99	neutral	0.7	neutral	2.35	18.47	deleterious	0.59098804	0.85	0.56	disease	0.09	neutral	0.33	neutral	0.05	neutral	9	0.99	deleterious	0.1	neutral	-2	neutral	0.67	deleterious	-2.36	low_impact	-0.1	medium_impact	-0.04	medium_impact	0.64	0.85	NA	NA	0.59	P	0.44	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11235	11235	C	G	MI.17330	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	476	159	P	R	cCc/cGc	5.6	1	0	probably_damaging	1	deleterious	0	neutral	4.55	neutral	-1.1	deleterious	-6.95	high_impact	4.41	0.59	damaging	0.08	damaging	3.57	23.10	deleterious	0.05	0.35	NA	NA	0.92	disease	0.78	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.24	high_impact	0.49	0.8	47.06	9.43	0.68	P	0.58	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11237	11237	C	A	MI.17331	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	478	160	L	M	Cta/Ata	-7.55	0	0	probably_damaging	1	neutral	0.26	neutral	3.78	deleterious	-3.07	neutral	-1.54	low_impact	1.38	0.5	damaging	0.1	damaging	3.70	23.30	deleterious	0.23	0.45	NA	NA	0.45	neutral	0.52	disease	0.32	neutral	4	1	deleterious	0.13	neutral	-2	neutral	0.77	deleterious	-3.54	low_impact	-0.05	medium_impact	0.24	medium_impact	0.44	0.8	47.71	9.19	0.31	N	0.90	polymorphism	1	0.03	rs28546714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11237	11237	C	G	MI.17332	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	478	160	L	V	Cta/Gta	-7.55	0	0	probably_damaging	1	deleterious	0.02	neutral	3.7	deleterious	-3.97	neutral	-2.32	medium_impact	3.23	0.41	damaging	0.07	damaging	3.36	22.90	deleterious	0.21	0.45	NA	NA	0.62	disease	0.64	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.75	medium_impact	2.07	high_impact	0.41	0.8	47.71	9.19	0.4	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11238	11238	T	C	MI.17333	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	479	160	L	P	cTa/cCa	-0.17	0	0	probably_damaging	1	deleterious	0.03	neutral	3.61	deleterious	-8.26	deleterious	-5.41	high_impact	4.28	0.39	damaging	0.05	damaging	3.82	23.40	deleterious	0.03	0.35	NA	NA	0.8	disease	0.75	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-0.64	medium_impact	3.11	high_impact	0.28	0.8	47.71	9.19	0.49	N	0.98	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11238	11238	T	G	MI.17334	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	479	160	L	R	cTa/cGa	-0.17	0	0	probably_damaging	1	deleterious	0	neutral	3.62	deleterious	-7.9	deleterious	-4.64	high_impact	4.28	0.43	damaging	0.05	damaging	4.12	23.80	deleterious	0.03	0.35	NA	NA	0.88	disease	0.74	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	3.11	high_impact	0.16	0.8	47.71	9.19	0.47	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11238	11238	T	A	MI.17335	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	479	160	L	Q	cTa/cAa	-0.17	0	0	probably_damaging	1	deleterious	0	neutral	3.62	deleterious	-7.77	deleterious	-4.64	high_impact	4.28	0.41	damaging	0.05	damaging	3.98	23.60	deleterious	0.04	0.35	NA	NA	0.8	disease	0.64	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.11	high_impact	0.26	0.8	47.71	9.19	0.49	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11240	11240	C	T	MI.17336	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	481	161	L	F	Ctc/Ttc	-13.54	0	0	probably_damaging	1	neutral	0.09	neutral	3.59	deleterious	-3.63	deleterious	-3.09	medium_impact	2.75	0.54	damaging	0.09	damaging	3.93	23.50	deleterious	0.09	0.35	NA	NA	0.67	disease	0.64	disease	0.61	disease	2	1	deleterious	0.05	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.36	medium_impact	1.6	medium_impact	0.37	0.8	47.28	9.47	0.26	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	C11240T	Leigh Syndrome	-	+	Reported	1	.	P	P	damaging
chrM	11240	11240	C	G	MI.17337	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	481	161	L	V	Ctc/Gtc	-13.54	0	0	probably_damaging	1	deleterious	0	neutral	3.54	deleterious	-4.28	neutral	-2.32	high_impact	4.15	0.59	damaging	0.13	damaging	3.37	22.90	deleterious	0.11	0.4	NA	NA	0.56	disease	0.59	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.98	high_impact	0.46	0.8	47.28	9.47	0.37	N	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11240	11240	C	A	MI.17338	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	481	161	L	I	Ctc/Atc	-13.54	0	0	probably_damaging	1	deleterious	0.01	neutral	3.59	deleterious	-3.69	neutral	-1.54	medium_impact	3.3	0.6	damaging	0.15	damaging	4.05	23.70	deleterious	0.15	0.4	NA	NA	0.55	disease	0.55	disease	0.63	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	2.14	high_impact	0.38	0.8	47.28	9.47	0.34	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11241	11241	T	G	MI.17339	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	482	161	L	R	cTc/cGc	-3.17	0	0	probably_damaging	1	deleterious	0	neutral	3.46	deleterious	-7.78	deleterious	-4.64	high_impact	4.5	0.55	damaging	0.09	damaging	4.11	23.70	deleterious	0.02	0.35	NA	NA	0.84	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.13	0.8	47.28	9.47	0.47	N	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8502	8502	A	G	MI.1734	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	137	46	N	S	aAt/aGt	-0.1	0	0	possibly_damaging	0.87	neutral	0.41	neutral	1.59	neutral	-0.81	neutral	-0.15	neutral_impact	0.55	1	neutral	0.95	neutral	0.64	8.42	deleterious	0.88141185	0.90	0.29	neutral	0.03	neutral	0.2	neutral	0.06	neutral	9	0.87	neutral	0.27	neutral	-3	neutral	0.59	deleterious	-1.54	low_impact	0.2	medium_impact	-0.63	medium_impact	0.51	0.85	NA	NA	0.54	N	0.12	polymorphism	1	0.01	rs879247004	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11241	11241	T	C	MI.17340	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	482	161	L	P	cTc/cCc	-3.17	0	0	probably_damaging	1	deleterious	0	neutral	3.46	deleterious	-8.21	deleterious	-5.41	high_impact	4.15	0.54	damaging	0.09	damaging	3.90	23.50	deleterious	0.02	0.35	NA	NA	0.76	disease	0.76	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	2.98	high_impact	0.23	0.8	47.28	9.47	0.37	N	0.98	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11241	11241	T	A	MI.17341	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	482	161	L	H	cTc/cAc	-3.17	0	0	probably_damaging	1	deleterious	0	neutral	3.46	deleterious	-8.45	deleterious	-5.41	high_impact	4.5	0.53	damaging	0.09	damaging	4.19	23.80	deleterious	0.03	0.35	NA	NA	0.77	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.18	0.8	47.28	9.47	0.4	N	0.96	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11243	11243	A	T	MI.17342	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	484	162	I	F	Atc/Ttc	-1.09	0	0	probably_damaging	0.97	neutral	0.33	neutral	4.76	neutral	0.88	deleterious	-3.09	low_impact	1.82	0.66	neutral	0.15	damaging	3.72	23.30	deleterious	0.16	0.45	NA	NA	0.79	disease	0.57	disease	0.71	disease	4	0.97	neutral	0.18	neutral	-2	neutral	0.77	deleterious	-2.14	low_impact	0.03	medium_impact	0.68	medium_impact	0.49	0.8	18.74	17.42	0.3	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11243	11243	A	C	MI.17343	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	484	162	I	L	Atc/Ctc	-1.09	0	0	possibly_damaging	0.61	neutral	0.57	neutral	4.8	neutral	1.13	neutral	-1.54	low_impact	0.98	0.7	neutral	0.28	damaging	3.69	23.30	deleterious	0.18	0.45	NA	NA	0.62	disease	0.31	neutral	0.48	neutral	0	0.56	neutral	0.48	deleterious	-3	neutral	0.67	deleterious	-0.9	medium_impact	0.27	medium_impact	-0.16	medium_impact	0.38	0.8	18.74	17.42	0.33	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11243	11243	A	G	MI.17344	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	484	162	I	V	Atc/Gtc	-1.09	0	0	benign	0.12	neutral	1	neutral	4.67	neutral	0.21	neutral	0.21	neutral_impact	-0.06	0.69	neutral	0.97	neutral	0.27	5.44	deleterious	0.35	0.5	NA	NA	0.06	neutral	0.26	neutral	0.17	neutral	7	0.11	neutral	0.94	deleterious	-6	neutral	0.59	deleterious	0.1	medium_impact	1.88	high_impact	-1.19	low_impact	0.26	0.8	18.74	17.42	0.36	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11244	11244	T	C	MI.17345	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	485	162	I	T	aTc/aCc	-0.4	0	0	probably_damaging	0.91	neutral	0.05	neutral	4.56	neutral	-1.37	deleterious	-2.87	medium_impact	2.56	0.77	neutral	0.41	neutral	3.35	22.90	deleterious	0.09	0.35	NA	NA	0.6	disease	0.38	neutral	0.49	neutral	0	0.98	deleterious	0.07	neutral	1	deleterious	0.72	deleterious	-1.66	low_impact	-0.52	medium_impact	1.41	medium_impact	0.27	0.8	18.74	17.42	0.39	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11244	11244	T	A	MI.17346	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	485	162	I	N	aTc/aAc	-0.4	0	0	probably_damaging	0.98	deleterious	0.03	neutral	4.56	neutral	-1.4	deleterious	-4.91	medium_impact	2.9	0.68	neutral	0.2	damaging	4.42	24.20	deleterious	0.13	0.4	NA	NA	0.85	disease	0.56	disease	0.76	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.80	deleterious	-2.31	low_impact	-0.64	medium_impact	1.74	medium_impact	0.27	0.8	18.74	17.42	0.33	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11244	11244	T	G	MI.17347	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	485	162	I	S	aTc/aGc	-0.4	0	0	probably_damaging	0.96	deleterious	0.02	neutral	4.54	neutral	-1.73	deleterious	-4.14	medium_impact	2.77	0.69	neutral	0.16	damaging	4.24	23.90	deleterious	0.06	0.35	NA	NA	0.82	disease	0.54	disease	0.76	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.78	deleterious	-2.01	low_impact	-0.75	medium_impact	1.61	medium_impact	0.29	0.8	18.74	17.42	0.32	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11245	11245	C	A	MI.17348	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	486	162	I	M	atC/atA	7.44	0.95	0	probably_damaging	0.97	neutral	0.17	neutral	4.56	neutral	-1.23	neutral	-1.82	low_impact	1.19	0.69	neutral	0.36	neutral	3.79	23.40	deleterious	0.21	0.45	NA	NA	0.54	disease	0.33	neutral	0.47	neutral	1	0.98	deleterious	0.1	neutral	-2	neutral	0.72	deleterious	-2.14	low_impact	-0.18	medium_impact	0.05	medium_impact	0.45	0.8	18.74	17.42	0.54	P	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11245	11245	C	G	MI.17349	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	486	162	I	M	atC/atG	7.44	0.95	0	probably_damaging	0.97	neutral	0.17	neutral	4.56	neutral	-1.23	neutral	-1.82	low_impact	1.19	0.69	neutral	0.36	neutral	3.30	22.90	deleterious	0.21	0.45	NA	NA	0.54	disease	0.33	neutral	0.47	neutral	1	0.98	deleterious	0.1	neutral	-2	neutral	0.72	deleterious	-2.14	low_impact	-0.18	medium_impact	0.05	medium_impact	0.45	0.8	18.74	17.42	0.53	P	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8503	8503	T	G	MI.1735	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	138	46	N	K	aaT/aaG	-0.33	0	0.01	probably_damaging	0.92	neutral	1	neutral	1.62	neutral	1.87	neutral	1.47	neutral_impact	-1.44	0.98	neutral	0.94	neutral	1.31	12.30	neutral	0.91929012	0.95	0.1	neutral	0.06	neutral	0.28	neutral	0.03	neutral	9	0.92	neutral	0.54	deleterious	-2	neutral	0.59	deleterious	-1.76	low_impact	1.98	high_impact	-2.33	low_impact	0.81	0.85	NA	NA	0.37	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11246	11246	G	C	MI.17350	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	487	163	A	P	Gca/Cca	-11.7	0	0	possibly_damaging	0.73	deleterious	0.02	neutral	4.4	deleterious	-5.12	deleterious	-3.45	high_impact	3.7	0.63	neutral	0.33	neutral	3.75	23.30	deleterious	0.02	0.35	NA	NA	0.9	disease	0.71	disease	0.8	disease	6	0.98	deleterious	0.15	neutral	5	deleterious	0.87	deleterious	-1.12	low_impact	-0.75	medium_impact	2.53	high_impact	0.50	0.8	27.02	31.13	0.38	N	0.94	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11246	11246	G	A	MI.17351	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	487	163	A	T	Gca/Aca	-11.7	0	0	benign	0.03	neutral	0.25	neutral	4.45	deleterious	-3.22	neutral	-2.36	low_impact	1.88	0.73	neutral	0.85	neutral	3.08	22.50	deleterious	0.11	0.4	NA	NA	0.63	disease	0.51	disease	0.46	neutral	1	0.74	neutral	0.61	deleterious	-6	neutral	0.75	deleterious	0.7	medium_impact	-0.07	medium_impact	0.73	medium_impact	0.82	0.85	27.02	31.13	0.41	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11246	11246	G	T	MI.17352	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	487	163	A	S	Gca/Tca	-11.7	0	0	benign	0.27	neutral	0.44	neutral	4.51	neutral	-2.4	neutral	-1.94	low_impact	1.12	0.74	neutral	0.77	neutral	3.60	23.20	deleterious	0.23	0.45	NA	NA	0.57	disease	0.36	neutral	0.46	neutral	1	0.47	neutral	0.59	deleterious	-6	neutral	0.77	deleterious	-0.31	medium_impact	0.14	medium_impact	-0.02	medium_impact	0.39	0.8	27.02	31.13	0.36	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11247	11247	C	A	MI.17353	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	488	163	A	E	gCa/gAa	1.91	0.42	0	possibly_damaging	0.54	deleterious	0.03	neutral	4.43	deleterious	-4.42	deleterious	-3.43	medium_impact	3.36	0.64	neutral	0.41	neutral	4.38	24.10	deleterious	0.02	0.35	NA	NA	0.91	disease	0.7	disease	0.8	disease	6	0.97	neutral	0.25	neutral	4	deleterious	0.85	deleterious	-0.78	medium_impact	-0.64	medium_impact	2.2	high_impact	0.27	0.8	27.02	31.13	0.39	N	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11247	11247	C	G	MI.17354	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	488	163	A	G	gCa/gGa	1.91	0.42	0	benign	0.41	neutral	0.43	neutral	4.66	neutral	0.65	deleterious	-2.88	low_impact	1.31	0.65	neutral	0.54	neutral	3.88	23.50	deleterious	0.23	0.45	NA	NA	0.61	disease	0.56	disease	0.48	neutral	1	0.51	neutral	0.51	deleterious	-6	neutral	0.75	deleterious	-0.57	medium_impact	0.13	medium_impact	0.17	medium_impact	0.58	0.8	27.02	31.13	0.29	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11247	11247	C	T	MI.17355	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	488	163	A	V	gCa/gTa	1.91	0.42	0	benign	0.02	neutral	0.4	neutral	4.5	neutral	-2.44	neutral	-2.5	medium_impact	1.94	0.77	neutral	0.56	neutral	4.35	24.10	deleterious	0.08	0.35	NA	NA	0.78	disease	0.54	disease	0.53	disease	1	0.58	neutral	0.69	deleterious	-3	neutral	0.80	deleterious	0.87	medium_impact	0.1	medium_impact	0.79	medium_impact	0.80	0.85	27.02	31.13	0.27	N	0.61	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11249	11249	C	G	MI.17356	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	490	164	L	V	Cta/Gta	-5.93	0	0	probably_damaging	1	neutral	0.09	neutral	4.63	neutral	-0.71	neutral	-2.26	medium_impact	2.22	0.45	damaging	0.09	damaging	3.36	22.90	deleterious	0.28	0.45	NA	NA	0.58	disease	0.59	disease	0.66	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.36	medium_impact	1.07	medium_impact	0.56	0.8	47.28	9.36	0.35	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11249	11249	C	A	MI.17357	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	490	164	L	M	Cta/Ata	-5.93	0	0	probably_damaging	1	neutral	0.11	neutral	4.59	neutral	-1.23	neutral	-1.5	medium_impact	2.34	0.48	damaging	0.11	damaging	3.69	23.30	deleterious	0.22	0.45	NA	NA	0.53	disease	0.49	neutral	0.51	disease	0	1	deleterious	0.06	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.31	medium_impact	1.19	medium_impact	0.53	0.8	47.28	9.36	0.38	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11250	11250	T	A	MI.17358	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	491	164	L	Q	cTa/cAa	-0.63	0	0	probably_damaging	1	deleterious	0	neutral	4.48	deleterious	-4.72	deleterious	-4.59	high_impact	3.97	0.41	damaging	0.06	damaging	4.10	23.70	deleterious	0.02	0.35	NA	NA	0.79	disease	0.6	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	2.8	high_impact	0.34	0.8	47.28	9.36	0.48	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11250	11250	T	G	MI.17359	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	491	164	L	R	cTa/cGa	-0.63	0	0	probably_damaging	1	deleterious	0	neutral	4.49	deleterious	-4.54	deleterious	-4.6	high_impact	3.97	0.38	damaging	0.05	damaging	4.08	23.70	deleterious	0.01	0.35	NA	NA	0.87	disease	0.72	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.8	high_impact	0.13	0.8	47.28	9.36	0.52	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8503	8503	T	A	MI.1736	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	138	46	N	K	aaT/aaA	-0.33	0	0.01	probably_damaging	0.92	neutral	1	neutral	1.62	neutral	1.87	neutral	1.47	neutral_impact	-1.44	0.98	neutral	0.94	neutral	1.58	13.73	neutral	0.91929012	0.95	0.1	neutral	0.06	neutral	0.28	neutral	0.03	neutral	9	0.92	neutral	0.54	deleterious	-2	neutral	0.59	deleterious	-1.76	low_impact	1.98	high_impact	-2.33	low_impact	0.81	0.85	NA	NA	0.37	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11250	11250	T	C	MI.17360	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	491	164	L	P	cTa/cCa	-0.63	0	0	probably_damaging	1	deleterious	0	neutral	4.48	deleterious	-5.11	deleterious	-5.37	high_impact	3.97	0.36	damaging	0.05	damaging	3.87	23.50	deleterious	0.02	0.35	NA	NA	0.85	disease	0.73	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.8	high_impact	0.39	0.8	47.28	9.36	0.52	N	0.98	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11252	11252	A	T	MI.17361	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	493	165	I	F	Att/Ttt	-5.93	0	0	benign	0.38	neutral	0.46	neutral	4.57	neutral	-0.76	neutral	-1.87	neutral_impact	0.64	0.72	neutral	0.57	neutral	2.09	16.82	deleterious	0.18	0.45	NA	NA	0.48	neutral	0.37	neutral	0.26	neutral	5	0.47	neutral	0.54	deleterious	-6	neutral	0.46	deleterious	-0.52	medium_impact	0.16	medium_impact	-0.49	medium_impact	0.57	0.8	8.5	11.75	0.32	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11252	11252	A	G	MI.17362	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	493	165	I	V	Att/Gtt	-5.93	0	0	benign	0.01	neutral	0.1	neutral	4.57	neutral	-0.36	neutral	-0.42	low_impact	1	0.82	neutral	0.98	neutral	0.01	2.72	deleterious	0.49	0.55	NA	NA	0.23	neutral	0.35	neutral	0.15	neutral	7	0.9	neutral	0.55	deleterious	-6	neutral	0.08	neutral	1.16	medium_impact	-0.33	medium_impact	-0.14	medium_impact	0.38	0.8	8.5	11.75	0.45	N	0.12	polymorphism	1	0.01	rs879229170	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11252	11252	A	C	MI.17363	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	493	165	I	L	Att/Ctt	-5.93	0	0	benign	0.01	neutral	1	neutral	4.76	neutral	0.5	neutral	0.24	neutral_impact	-1.19	0.74	neutral	0.97	neutral	-0.90	0.03	neutral	0.25	0.45	NA	NA	0.13	neutral	0.21	neutral	0.23	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.16	medium_impact	1.88	high_impact	-2.3	low_impact	0.51	0.8	8.5	11.75	0.31	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11253	11253	T	A	MI.17364	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	494	165	I	N	aTt/aAt	-0.86	0	0.01	benign	0.38	deleterious	0	neutral	4.46	deleterious	-4.28	deleterious	-3.41	medium_impact	2.29	0.68	neutral	0.53	neutral	2.85	21.60	deleterious	0.11	0.4	NA	NA	0.73	disease	0.58	disease	0.73	disease	5	1	deleterious	0.31	neutral	1	deleterious	0.46	deleterious	-0.52	medium_impact	-1.48	low_impact	1.14	medium_impact	0.30	0.8	8.5	11.75	0.34	N	0.78	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11253	11253	T	G	MI.17365	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	494	165	I	S	aTt/aGt	-0.86	0	0.01	benign	0.02	deleterious	0.02	neutral	4.68	neutral	-1.18	deleterious	-2.62	low_impact	1.64	0.69	neutral	0.79	neutral	2.34	18.43	deleterious	0.04	0.35	NA	NA	0.6	disease	0.55	disease	0.52	disease	0	0.98	neutral	0.5	deleterious	-2	neutral	0.24	neutral	0.87	medium_impact	-0.75	medium_impact	0.5	medium_impact	0.28	0.8	8.5	11.75	0.4	N	0.26	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11253	11253	T	C	MI.17366	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	494	165	I	T	aTt/aCt	-0.86	0	0.01	benign	0.01	deleterious	0.02	neutral	4.5	neutral	-2.45	neutral	-1.46	low_impact	1.74	0.8	neutral	0.95	neutral	0.33	6.02	deleterious	0.08	0.35	NA	NA	0.36	neutral	0.39	neutral	0.15	neutral	7	0.98	neutral	0.51	deleterious	-2	neutral	0.10	neutral	1.16	medium_impact	-0.75	medium_impact	0.6	medium_impact	0.31	0.8	8.5	11.75	0.53	P	0.43	disease_causing_automatic	0	0.03	rs200145866	Pathogenic	Leber's_optic_atrophy	76417	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	COSM6716767	.	.	T11253C	LHON, PD	+	-	Reported	4	P	P	P	neutral
chrM	11254	11254	T	A	MI.17367	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	495	165	I	M	atT/atA	1.68	0.01	0	benign	0.03	neutral	0.19	neutral	4.52	neutral	-2.05	neutral	-0.63	neutral_impact	0.76	0.76	neutral	0.92	neutral	2.13	17.02	deleterious	0.33	0.5	NA	NA	0.34	neutral	0.32	neutral	0.14	neutral	7	0.8	neutral	0.58	deleterious	-6	neutral	0.46	deleterious	0.7	medium_impact	-0.15	medium_impact	-0.37	medium_impact	0.55	0.8	8.5	11.75	0.44	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11254	11254	T	G	MI.17368	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	495	165	I	M	atT/atG	1.68	0.01	0	benign	0.03	neutral	0.19	neutral	4.52	neutral	-2.05	neutral	-0.63	neutral_impact	0.76	0.76	neutral	0.92	neutral	1.85	15.31	deleterious	0.33	0.5	NA	NA	0.34	neutral	0.32	neutral	0.14	neutral	7	0.8	neutral	0.58	deleterious	-6	neutral	0.46	deleterious	0.7	medium_impact	-0.15	medium_impact	-0.37	medium_impact	0.55	0.8	8.5	11.75	0.45	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11255	11255	T	A	MI.17369	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	496	166	Y	N	Tac/Aac	-10.78	0	0.02	benign	0.23	neutral	0.26	neutral	4.52	deleterious	-3.98	deleterious	-3.63	medium_impact	2.17	0.76	neutral	0.72	neutral	0.93	10.26	neutral	0.09	0.35	NA	NA	0.57	disease	0.45	neutral	0.47	neutral	1	0.69	neutral	0.52	deleterious	-3	neutral	0.17	neutral	-0.23	medium_impact	-0.05	medium_impact	1.02	medium_impact	0.10	0.8	15.47	15.4	0.4	N	0.37	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8504	8504	T	C	MI.1737	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	139	47	Y	H	Tat/Cat	-3.57	0	0	possibly_damaging	0.49	neutral	0.57	neutral	1.28	deleterious	-4.61	neutral	1.55	neutral_impact	-1.95	1	neutral	0.96	neutral	-0.38	0.44	neutral	0.75672260	0.85	0.15	neutral	0.04	neutral	0.28	neutral	0.04	neutral	9	0.45	neutral	0.54	deleterious	-3	neutral	0.37	neutral	-0.74	medium_impact	0.36	medium_impact	-2.77	low_impact	0.59	0.85	NA	NA	0.38	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11255	11255	T	C	MI.17370	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	496	166	Y	H	Tac/Cac	-10.78	0	0.02	benign	0	neutral	0.37	neutral	4.51	deleterious	-3.76	neutral	-1.97	low_impact	1.8	0.76	neutral	0.98	neutral	0.18	4.50	deleterious	0.21	0.45	NA	NA	0.45	neutral	0.35	neutral	0.2	neutral	6	0.63	neutral	0.69	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	0.07	medium_impact	0.66	medium_impact	0.14	0.8	15.47	15.4	0.42	N	0.01	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11255	11255	T	G	MI.17371	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	496	166	Y	D	Tac/Gac	-10.78	0	0.02	benign	0.29	neutral	0.12	neutral	4.51	deleterious	-4.93	deleterious	-4.39	medium_impact	2.64	0.75	neutral	0.52	neutral	1.93	15.78	deleterious	0.04	0.35	NA	NA	0.71	disease	0.57	disease	0.71	disease	4	0.86	neutral	0.42	neutral	-3	neutral	0.23	neutral	-0.35	medium_impact	-0.28	medium_impact	1.49	medium_impact	0.04	0.8	15.47	15.4	0.41	N	0.69	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11256	11256	A	G	MI.17372	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	497	166	Y	C	tAc/tGc	-2.24	0	0	possibly_damaging	0.79	neutral	0.1	neutral	4.51	deleterious	-3.46	deleterious	-3.64	medium_impact	2.3	0.75	neutral	0.48	neutral	3.05	22.40	deleterious	0.05	0.35	NA	NA	0.71	disease	0.48	neutral	0.5	neutral	0	0.93	neutral	0.16	neutral	0	NA	0.58	deleterious	-1.26	low_impact	-0.33	medium_impact	1.15	medium_impact	0.04	0.8	15.47	15.4	0.41	N	0.58	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11256	11256	A	C	MI.17373	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	497	166	Y	S	tAc/tCc	-2.24	0	0	benign	0.23	neutral	0.42	neutral	4.56	neutral	-2.25	deleterious	-3.3	low_impact	1.27	0.73	neutral	0.98	neutral	0.35	6.20	deleterious	0.07	0.35	NA	NA	0.46	neutral	0.34	neutral	0.23	neutral	5	0.49	neutral	0.6	deleterious	-6	neutral	0.16	neutral	-0.23	medium_impact	0.12	medium_impact	0.13	medium_impact	0.12	0.8	15.47	15.4	0.39	N	0.22	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11256	11256	A	T	MI.17374	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	497	166	Y	F	tAc/tTc	-2.24	0	0	benign	0	neutral	0.59	neutral	4.54	neutral	-0.67	neutral	-1.19	low_impact	0.9	0.78	neutral	0.97	neutral	-0.06	2.04	deleterious	0.33	0.5	NA	NA	0.33	neutral	0.23	neutral	0.18	neutral	6	0.4	neutral	0.8	deleterious	-6	neutral	0.17	neutral	2.1	high_impact	0.29	medium_impact	-0.24	medium_impact	0.28	0.8	15.47	15.4	0.35	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11258	11258	A	C	MI.17375	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	499	167	T	P	Act/Cct	-10.08	0	0	possibly_damaging	0.73	deleterious	0	neutral	4.58	deleterious	-3.51	neutral	-1.73	low_impact	1.66	0.67	neutral	0.48	neutral	3.37	22.90	deleterious	0.05	0.35	NA	NA	0.77	disease	0.59	disease	0.77	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.81	deleterious	-1.12	low_impact	-1.48	low_impact	0.52	medium_impact	0.42	0.8	23.97	18.24	0.35	N	0.86	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11258	11258	A	T	MI.17376	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	499	167	T	S	Act/Tct	-10.08	0	0	benign	0.27	deleterious	0.03	neutral	4.63	neutral	-1.27	neutral	-0.86	neutral_impact	0.46	0.8	neutral	0.84	neutral	3.08	22.50	deleterious	0.4	0.5	NA	NA	0.29	neutral	0.42	neutral	0.17	neutral	7	0.97	neutral	0.38	neutral	-2	neutral	0.71	deleterious	-0.31	medium_impact	-0.64	medium_impact	-0.67	medium_impact	0.64	0.8	23.97	18.24	0.43	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11258	11258	A	G	MI.17377	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	499	167	T	A	Act/Gct	-10.08	0	0	benign	0.02	deleterious	0.03	neutral	4.64	neutral	-0.12	neutral	-0.33	neutral_impact	0.62	0.78	neutral	0.89	neutral	3.26	22.80	deleterious	0.28	0.45	NA	NA	0.24	neutral	0.45	neutral	0.17	neutral	7	0.97	neutral	0.51	deleterious	-2	neutral	0.70	deleterious	0.87	medium_impact	-0.64	medium_impact	-0.51	medium_impact	0.36	0.8	23.97	18.24	0.44	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11259	11259	C	T	MI.17378	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	500	167	T	I	aCt/aTt	-1.32	0	0	benign	0.02	neutral	0.37	neutral	4.86	neutral	1.02	neutral	1.96	neutral_impact	-1.01	0.77	neutral	0.99	neutral	2.42	18.93	deleterious	0.11	0.4	NA	NA	0.24	neutral	0.2	neutral	0.18	neutral	6	0.62	neutral	0.68	deleterious	-6	neutral	0.70	deleterious	0.87	medium_impact	0.07	medium_impact	-2.13	low_impact	0.56	0.8	23.97	18.24	0.36	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11259	11259	C	G	MI.17379	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	500	167	T	S	aCt/aGt	-1.32	0	0	benign	0.27	deleterious	0.03	neutral	4.63	neutral	-1.27	neutral	-0.86	neutral_impact	0.46	0.8	neutral	0.84	neutral	3.43	23.00	deleterious	0.4	0.5	NA	NA	0.29	neutral	0.42	neutral	0.17	neutral	7	0.97	neutral	0.38	neutral	-2	neutral	0.71	deleterious	-0.31	medium_impact	-0.64	medium_impact	-0.67	medium_impact	0.64	0.8	23.97	18.24	0.43	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8504	8504	T	A	MI.1738	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	139	47	Y	N	Tat/Aat	-3.57	0	0	benign	0.37	neutral	0.52	neutral	1.27	deleterious	-6.24	neutral	-1.74	neutral_impact	-0.08	1	neutral	0.74	neutral	1.30	12.25	neutral	0.71795062	0.85	0.25	neutral	0.28	neutral	0.33	neutral	0.13	neutral	7	0.41	neutral	0.58	deleterious	-6	neutral	0.42	neutral	-0.54	medium_impact	0.31	medium_impact	-1.17	low_impact	0.47	0.85	NA	NA	0.41	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11259	11259	C	A	MI.17380	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	500	167	T	N	aCt/aAt	-1.32	0	0	possibly_damaging	0.51	deleterious	0.03	neutral	4.61	neutral	-2.77	neutral	-1.59	neutral_impact	0.77	0.69	neutral	0.66	neutral	3.52	23.10	deleterious	0.27	0.45	NA	NA	0.52	disease	0.44	neutral	0.52	disease	0	0.97	neutral	0.26	neutral	1	deleterious	0.74	deleterious	-0.73	medium_impact	-0.64	medium_impact	-0.36	medium_impact	0.64	0.8	23.97	18.24	0.4	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11261	11261	C	A	MI.17381	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	502	168	H	N	Cac/Aac	-14.93	0	0	benign	0.01	neutral	0.31	neutral	4.63	neutral	-0.72	neutral	-0.72	neutral_impact	-0.18	0.75	neutral	0.84	neutral	2.00	16.22	deleterious	0.23	0.45	NA	NA	0.47	neutral	0.38	neutral	0.26	neutral	5	0.69	neutral	0.65	deleterious	-6	neutral	0.22	neutral	1.16	medium_impact	0.01	medium_impact	-1.3	low_impact	0.24	0.8	30.72	29.62	0.43	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11261	11261	C	G	MI.17382	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	502	168	H	D	Cac/Gac	-14.93	0	0	benign	0.11	neutral	0.13	neutral	4.62	neutral	-1.59	neutral	-1.08	low_impact	1.21	0.75	neutral	0.56	neutral	1.98	16.08	deleterious	0.05	0.35	NA	NA	0.68	disease	0.65	disease	0.7	disease	4	0.85	neutral	0.51	deleterious	-6	neutral	0.32	neutral	0.14	medium_impact	-0.26	medium_impact	0.07	medium_impact	0.24	0.8	30.72	29.62	0.37	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11261	11261	C	T	MI.17383	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	502	168	H	Y	Cac/Tac	-14.93	0	0	benign	0	neutral	1	neutral	5	neutral	3.79	neutral	-0.59	neutral_impact	-0.71	0.79	neutral	0.85	neutral	0.57	7.92	deleterious	0.27	0.45	NA	NA	0.31	neutral	0.31	neutral	0.15	neutral	7	0	neutral	1	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	1.88	high_impact	-1.83	low_impact	0.19	0.8	30.72	29.62	0.24	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11262	11262	A	G	MI.17384	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	503	168	H	R	cAc/cGc	-0.4	0	0	benign	0.11	neutral	0.19	neutral	4.64	neutral	-0.46	neutral	-0.21	low_impact	1.9	0.8	neutral	0.58	neutral	1.07	11.06	neutral	0.12	0.4	NA	NA	0.72	disease	0.57	disease	0.72	disease	4	0.78	neutral	0.54	deleterious	-6	neutral	0.29	neutral	0.14	medium_impact	-0.15	medium_impact	0.75	medium_impact	0.25	0.8	30.72	29.62	0.33	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11262	11262	A	T	MI.17385	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	503	168	H	L	cAc/cTc	-0.4	0	0	benign	0	neutral	0.49	neutral	4.88	neutral	3.21	neutral	-2.03	neutral_impact	0.26	0.75	neutral	0.84	neutral	1.82	15.09	deleterious	0.06	0.35	NA	NA	0.75	disease	0.52	disease	0.63	disease	3	0.51	neutral	0.75	deleterious	-6	neutral	0.24	neutral	2.1	high_impact	0.19	medium_impact	-0.87	medium_impact	0.10	0.8	30.72	29.62	0.35	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11262	11262	A	C	MI.17386	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	503	168	H	P	cAc/cCc	-0.4	0	0	benign	0.36	neutral	0.11	neutral	4.63	neutral	-1.06	neutral	-1.71	medium_impact	2.25	0.69	neutral	0.41	neutral	1.55	13.57	neutral	0.05	0.35	NA	NA	0.88	disease	0.69	disease	0.82	disease	6	0.87	neutral	0.38	neutral	-3	neutral	0.48	deleterious	-0.48	medium_impact	-0.31	medium_impact	1.1	medium_impact	0.08	0.8	30.72	29.62	0.35	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11263	11263	C	A	MI.17387	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	504	168	H	Q	caC/caA	6.75	0.85	0	benign	0.01	neutral	0.5	neutral	4.63	neutral	-0.62	neutral	1.96	neutral_impact	-0.52	0.73	neutral	0.97	neutral	-0.79	0.05	neutral	0.18	0.45	NA	NA	0.11	neutral	0.29	neutral	0.19	neutral	6	0.49	neutral	0.75	deleterious	-6	neutral	0.11	neutral	1.16	medium_impact	0.2	medium_impact	-1.64	low_impact	0.34	0.8	30.72	29.62	0.5	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11263	11263	C	G	MI.17388	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	504	168	H	Q	caC/caG	6.75	0.85	0	benign	0.01	neutral	0.5	neutral	4.63	neutral	-0.62	neutral	1.96	neutral_impact	-0.52	0.73	neutral	0.97	neutral	-1.17	0.01	neutral	0.18	0.45	NA	NA	0.11	neutral	0.29	neutral	0.19	neutral	6	0.49	neutral	0.75	deleterious	-6	neutral	0.11	neutral	1.16	medium_impact	0.2	medium_impact	-1.64	low_impact	0.34	0.8	30.72	29.62	0.5	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11264	11264	A	G	MI.17389	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	505	169	N	D	Aac/Gac	-1.78	0	0	possibly_damaging	0.89	neutral	0.12	neutral	4.59	neutral	-1.76	deleterious	-2.74	medium_impact	2.25	0.76	neutral	0.31	neutral	3.65	23.20	deleterious	0.49	0.55	NA	NA	0.73	disease	0.67	disease	0.68	disease	4	0.96	neutral	0.12	neutral	0	NA	0.80	deleterious	-1.57	low_impact	-0.28	medium_impact	1.1	medium_impact	0.28	0.8	20.26	14.59	0.37	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8504	8504	T	G	MI.1739	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	139	47	Y	D	Tat/Gat	-3.57	0	0	benign	0.37	neutral	0.44	neutral	1.27	deleterious	-7.16	deleterious	-2.81	neutral_impact	0.34	0.99	neutral	0.4	neutral	1.16	11.51	neutral	0.68116519	0.85	0.27	neutral	0.31	neutral	0.44	neutral	0.15	neutral	7	0.49	neutral	0.54	deleterious	-6	neutral	0.42	neutral	-0.54	medium_impact	0.23	medium_impact	-0.81	medium_impact	0.53	0.85	NA	NA	0.42	N	0.35	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11264	11264	A	T	MI.17390	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	505	169	N	Y	Aac/Tac	-1.78	0	0	probably_damaging	0.99	neutral	0.24	neutral	4.68	neutral	0.63	deleterious	-4.69	low_impact	1.64	0.77	neutral	0.21	damaging	3.49	23.10	deleterious	0.11	0.4	NA	NA	0.81	disease	0.41	neutral	0.54	disease	1	0.99	deleterious	0.13	neutral	-2	neutral	0.82	deleterious	-2.59	low_impact	-0.08	medium_impact	0.5	medium_impact	0.30	0.8	20.26	14.59	0.27	N	0.62	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11264	11264	A	C	MI.17391	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	505	169	N	H	Aac/Cac	-1.78	0	0	probably_damaging	0.99	neutral	0.11	neutral	4.62	neutral	-0.59	deleterious	-2.83	low_impact	1.79	0.77	neutral	0.44	neutral	2.88	21.80	deleterious	0.33	0.5	NA	NA	0.75	disease	0.46	neutral	0.54	disease	1	1	deleterious	0.06	neutral	-2	neutral	0.80	deleterious	-2.59	low_impact	-0.31	medium_impact	0.65	medium_impact	0.20	0.8	20.26	14.59	0.32	N	0.69	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11265	11265	A	C	MI.17392	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	506	169	N	T	aAc/aCc	0.52	0	0	probably_damaging	0.95	neutral	0.22	neutral	4.65	neutral	0.07	deleterious	-3.26	low_impact	1.61	0.72	neutral	0.81	neutral	2.12	16.96	deleterious	0.25	0.45	NA	NA	0.48	neutral	0.3	neutral	0.3	neutral	4	0.97	neutral	0.14	neutral	-2	neutral	0.73	deleterious	-1.92	low_impact	-0.11	medium_impact	0.47	medium_impact	0.31	0.8	20.26	14.59	0.41	N	0.79	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11265	11265	A	T	MI.17393	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	506	169	N	I	aAc/aTc	0.52	0	0	probably_damaging	0.98	neutral	0.08	neutral	4.65	neutral	0.09	deleterious	-5.42	medium_impact	2.13	0.79	neutral	0.22	damaging	3.92	23.50	deleterious	0.13	0.4	NA	NA	0.85	disease	0.57	disease	0.71	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.82	deleterious	-2.31	low_impact	-0.39	medium_impact	0.98	medium_impact	0.21	0.8	20.26	14.59	0.28	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11265	11265	A	G	MI.17394	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	506	169	N	S	aAc/aGc	0.52	0	0	possibly_damaging	0.86	neutral	0.43	neutral	4.7	neutral	0.83	deleterious	-2.58	neutral_impact	0.72	0.71	neutral	0.9	neutral	1.92	15.73	deleterious	0.46	0.55	NA	NA	0.51	disease	0.33	neutral	0.45	neutral	1	0.85	neutral	0.29	neutral	-3	neutral	0.76	deleterious	-1.46	low_impact	0.13	medium_impact	-0.41	medium_impact	0.20	0.8	20.26	14.59	0.34	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11266	11266	C	G	MI.17395	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	507	169	N	K	aaC/aaG	0.06	0	0	probably_damaging	0.94	neutral	0.34	neutral	4.61	neutral	-0.78	deleterious	-2.88	low_impact	1.38	0.75	neutral	0.77	neutral	2.46	19.21	deleterious	0.4	0.5	NA	NA	0.72	disease	0.44	neutral	0.52	disease	0	0.94	neutral	0.2	neutral	-2	neutral	0.81	deleterious	-1.84	low_impact	0.04	medium_impact	0.24	medium_impact	0.37	0.8	20.26	14.59	0.36	N	0.95	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11266	11266	C	A	MI.17396	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	507	169	N	K	aaC/aaA	0.06	0	0	probably_damaging	0.94	neutral	0.34	neutral	4.61	neutral	-0.78	deleterious	-2.88	low_impact	1.38	0.75	neutral	0.77	neutral	2.90	21.90	deleterious	0.4	0.5	NA	NA	0.72	disease	0.44	neutral	0.52	disease	0	0.94	neutral	0.2	neutral	-2	neutral	0.81	deleterious	-1.84	low_impact	0.04	medium_impact	0.24	medium_impact	0.37	0.8	20.26	14.59	0.35	N	0.95	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11267	11267	A	T	MI.17397	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	508	170	T	S	Acc/Tcc	-6.63	0	0	benign	0.01	neutral	0.69	neutral	4.68	neutral	0.52	neutral	0.53	neutral_impact	0.24	0.75	neutral	1	neutral	0.38	6.43	deleterious	0.38	0.5	NA	NA	0.13	neutral	0.16	neutral	0.2	neutral	6	0.29	neutral	0.84	deleterious	-6	neutral	0.68	deleterious	1.16	medium_impact	0.4	medium_impact	-0.89	medium_impact	0.50	0.8	21.57	16.77	0.43	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11267	11267	A	C	MI.17398	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	508	170	T	P	Acc/Ccc	-6.63	0	0	benign	0.4	neutral	0.2	neutral	4.57	neutral	-2.44	neutral	-1.64	medium_impact	2.68	0.66	neutral	0.42	neutral	3.28	22.80	deleterious	0.04	0.35	NA	NA	0.8	disease	0.51	disease	0.69	disease	4	0.77	neutral	0.4	neutral	-3	neutral	0.80	deleterious	-0.55	medium_impact	-0.14	medium_impact	1.53	medium_impact	0.29	0.8	21.57	16.77	0.34	N	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11267	11267	A	G	MI.17399	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	508	170	T	A	Acc/Gcc	-6.63	0	0	benign	0.12	neutral	0.51	neutral	4.66	neutral	0.21	neutral	-0.91	low_impact	1.4	0.79	neutral	0.8	neutral	2.16	17.22	deleterious	0.29	0.45	NA	NA	0.3	neutral	0.35	neutral	0.16	neutral	7	0.41	neutral	0.7	deleterious	-6	neutral	0.70	deleterious	0.1	medium_impact	0.21	medium_impact	0.26	medium_impact	0.29	0.8	21.57	16.77	0.33	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8606	8606	C	G	MI.174	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	80	27	P	R	cCc/cGc	5.45	1	0	probably_damaging	1	neutral	0.35	neutral	4.34	neutral	-1.48	deleterious	-8.12	high_impact	3.86	0.66	neutral	0.43	neutral	3.45	23.00	deleterious	0.28	0.65	0.42	neutral	0.88	disease	0.73	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.14	medium_impact	2.21	high_impact	0.51	0.9	48.23	8.81	0.55	P	0.70	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8505	8505	A	G	MI.1740	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	140	47	Y	C	tAt/tGt	-0.57	0	0	possibly_damaging	0.66	neutral	0.18	neutral	1.27	deleterious	-5.97	deleterious	-3.94	low_impact	0.9	1	neutral	0.37	neutral	2.06	16.61	deleterious	0.74880421	0.85	0.56	disease	0.22	neutral	0.52	disease	0.16	neutral	7	0.84	neutral	0.26	neutral	-3	neutral	0.55	deleterious	-1.03	low_impact	-0.08	medium_impact	-0.33	medium_impact	0.15	0.85	NA	NA	0.55	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11268	11268	C	G	MI.17400	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	509	170	T	S	aCc/aGc	-3.86	0	0	benign	0.01	neutral	0.69	neutral	4.68	neutral	0.52	neutral	0.53	neutral_impact	0.24	0.75	neutral	1	neutral	0.77	9.28	deleterious	0.38	0.5	NA	NA	0.13	neutral	0.16	neutral	0.2	neutral	6	0.29	neutral	0.84	deleterious	-6	neutral	0.68	deleterious	1.16	medium_impact	0.4	medium_impact	-0.89	medium_impact	0.50	0.8	21.57	16.77	0.43	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11268	11268	C	T	MI.17401	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	509	170	T	I	aCc/aTc	-3.86	0	0	benign	0.26	neutral	0.43	neutral	4.74	neutral	1.1	neutral	-1.86	neutral_impact	0.68	0.79	neutral	0.87	neutral	2.83	21.50	deleterious	0.14	0.4	NA	NA	0.53	disease	0.38	neutral	0.51	disease	0	0.48	neutral	0.59	deleterious	-6	neutral	0.74	deleterious	-0.29	medium_impact	0.13	medium_impact	-0.45	medium_impact	0.44	0.8	21.57	16.77	0.28	N	0.45	polymorphism	1	0.02	rs879011423	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11268	11268	C	A	MI.17402	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	509	170	T	N	aCc/aAc	-3.86	0	0	benign	0	neutral	0.51	neutral	4.63	neutral	-0.18	neutral	0.35	neutral_impact	-0.15	0.77	neutral	0.99	neutral	1.54	13.51	neutral	0.31	0.45	NA	NA	0.3	neutral	0.19	neutral	0.16	neutral	7	0.48	neutral	0.76	deleterious	-6	neutral	0.70	deleterious	2.1	high_impact	0.21	medium_impact	-1.27	low_impact	0.63	0.8	21.57	16.77	0.41	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11270	11270	C	G	MI.17403	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	511	171	L	V	Cta/Gta	-11.01	0	0	benign	0.06	neutral	0.51	neutral	4.63	neutral	-0.53	neutral	-0.62	low_impact	1.07	0.81	neutral	0.97	neutral	2.16	17.28	deleterious	0.4	0.5	NA	NA	0.23	neutral	0.37	neutral	0.16	neutral	7	0.43	neutral	0.73	deleterious	-6	neutral	0.69	deleterious	0.41	medium_impact	0.21	medium_impact	-0.07	medium_impact	0.44	0.8	5.45	10.35	0.36	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11270	11270	C	A	MI.17404	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	511	171	L	M	Cta/Ata	-11.01	0	0	benign	0.32	neutral	0.27	neutral	4.6	neutral	-2.07	neutral	-0.09	neutral_impact	0.36	0.79	neutral	0.96	neutral	2.17	17.32	deleterious	0.32	0.5	NA	NA	0.12	neutral	0.21	neutral	0.26	neutral	5	0.68	neutral	0.48	deleterious	-6	neutral	0.67	deleterious	-0.41	medium_impact	-0.04	medium_impact	-0.77	medium_impact	0.44	0.8	5.45	10.35	0.45	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11271	11271	T	C	MI.17405	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	512	171	L	P	cTa/cCa	-3.86	0	0	probably_damaging	0.9	neutral	0.21	neutral	4.56	deleterious	-4.13	deleterious	-2.55	medium_impact	2.7	0.63	neutral	0.44	neutral	3.82	23.40	deleterious	0.02	0.35	NA	NA	0.76	disease	0.45	neutral	0.59	disease	2	0.94	neutral	0.16	neutral	1	deleterious	0.82	deleterious	-1.61	low_impact	-0.12	medium_impact	1.55	medium_impact	0.05	0.8	5.45	10.35	0.38	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11271	11271	T	G	MI.17406	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	512	171	L	R	cTa/cGa	-3.86	0	0	possibly_damaging	0.87	neutral	0.35	neutral	4.59	deleterious	-3.51	neutral	-2.06	medium_impact	2.15	0.72	neutral	0.51	neutral	4.05	23.70	deleterious	0.03	0.35	NA	NA	0.7	disease	0.59	disease	0.72	disease	4	0.88	neutral	0.24	neutral	0	NA	0.81	deleterious	-1.49	low_impact	0.05	medium_impact	1	medium_impact	0.09	0.8	5.45	10.35	0.32	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11271	11271	T	A	MI.17407	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	512	171	L	Q	cTa/cAa	-3.86	0	0	probably_damaging	0.9	neutral	0.32	neutral	4.59	deleterious	-3.25	neutral	-1.84	low_impact	1.66	0.77	neutral	0.69	neutral	3.93	23.50	deleterious	0.05	0.35	NA	NA	0.49	neutral	0.44	neutral	0.47	neutral	1	0.92	neutral	0.21	neutral	-2	neutral	0.73	deleterious	-1.61	low_impact	0.02	medium_impact	0.52	medium_impact	0.09	0.8	5.45	10.35	0.36	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11273	11273	G	A	MI.17408	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	514	172	G	S	Ggc/Agc	-2.01	0	0	probably_damaging	1	neutral	0.16	neutral	4.49	deleterious	-4.21	deleterious	-4.24	medium_impact	2.06	0.73	neutral	0.21	damaging	4.11	23.70	deleterious	0.07	0.35	NA	NA	0.7	disease	0.34	neutral	0.51	disease	0	1	deleterious	0.08	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	-0.2	medium_impact	0.91	medium_impact	0.52	0.8	47.71	9.06	0.38	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11273	11273	G	C	MI.17409	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	514	172	G	R	Ggc/Cgc	-2.01	0	0	probably_damaging	1	deleterious	0.01	neutral	4.31	deleterious	-4.48	deleterious	-5.68	high_impact	3.54	0.64	neutral	0.09	damaging	3.82	23.40	deleterious	0.03	0.35	NA	NA	0.9	disease	0.76	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-0.92	medium_impact	2.38	high_impact	0.49	0.8	47.71	9.06	0.33	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8505	8505	A	C	MI.1741	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	140	47	Y	S	tAt/tCt	-0.57	0	0	benign	0.19	neutral	0.77	neutral	1.27	deleterious	-5.65	neutral	-2.2	neutral_impact	-0.52	0.99	neutral	0.73	neutral	0.44	6.98	deleterious	0.67050158	0.85	0.2	neutral	0.18	neutral	0.32	neutral	0.12	neutral	8	0.13	neutral	0.79	deleterious	-6	neutral	0.19	neutral	-0.16	medium_impact	0.59	medium_impact	-1.54	low_impact	0.40	0.85	NA	NA	0.37	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11273	11273	G	T	MI.17410	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	514	172	G	C	Ggc/Tgc	-2.01	0	0	probably_damaging	1	deleterious	0.02	neutral	4.26	deleterious	-8.01	deleterious	-6.42	medium_impact	2.92	0.74	neutral	0.09	damaging	4.07	23.70	deleterious	0.03	0.35	NA	NA	0.88	disease	0.61	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.87	deleterious	-3.54	low_impact	-0.75	medium_impact	1.76	medium_impact	0.17	0.8	47.71	9.06	0.27	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11274	11274	G	C	MI.17411	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	515	172	G	A	gGc/gCc	4.44	1	0	probably_damaging	1	deleterious	0.04	neutral	4.33	deleterious	-3.86	deleterious	-4.26	medium_impact	2.54	0.74	neutral	0.2	damaging	3.05	22.40	deleterious	0.08	0.35	NA	NA	0.63	disease	0.58	disease	0.59	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.57	medium_impact	1.39	medium_impact	0.36	0.8	47.71	9.06	0.54	P	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11274	11274	G	T	MI.17412	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	515	172	G	V	gGc/gTc	4.44	1	0	probably_damaging	1	deleterious	0.01	neutral	4.29	deleterious	-5.33	deleterious	-6.37	medium_impact	2.99	0.67	neutral	0.11	damaging	3.69	23.30	deleterious	0.03	0.35	NA	NA	0.83	disease	0.62	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.88	deleterious	-3.54	low_impact	-0.92	medium_impact	1.83	medium_impact	0.15	0.8	47.71	9.06	0.43	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11274	11274	G	A	MI.17413	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	515	172	G	D	gGc/gAc	4.44	1	0	probably_damaging	1	neutral	0.08	neutral	4.31	deleterious	-4.18	deleterious	-5.01	medium_impact	1.95	0.7	neutral	0.13	damaging	3.80	23.40	deleterious	0.03	0.35	NA	NA	0.88	disease	0.67	disease	0.71	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.89	deleterious	-3.54	low_impact	-0.39	medium_impact	0.8	medium_impact	0.18	0.8	47.71	9.06	0.47	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11276	11276	T	C	MI.17414	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	517	173	S	P	Tca/Cca	-5.93	0	0	probably_damaging	1	deleterious	0.01	neutral	4.34	deleterious	-3.83	deleterious	-3.06	medium_impact	2.72	0.58	damaging	0.11	damaging	3.94	23.50	deleterious	0.04	0.35	NA	NA	0.88	disease	0.67	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.54	low_impact	-0.92	medium_impact	1.57	medium_impact	0.12	0.8	37.04	8.79	0.25	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11276	11276	T	G	MI.17415	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	517	173	S	A	Tca/Gca	-5.93	0	0	probably_damaging	1	deleterious	0.03	neutral	4.41	neutral	-1.88	neutral	-1.78	medium_impact	2.21	0.67	neutral	0.22	damaging	3.66	23.20	deleterious	0.27	0.45	NA	NA	0.46	neutral	0.67	disease	0.46	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-3.54	low_impact	-0.64	medium_impact	1.06	medium_impact	0.26	0.8	37.04	8.79	0.33	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11276	11276	T	A	MI.17416	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	517	173	S	T	Tca/Aca	-5.93	0	0	probably_damaging	1	neutral	1	neutral	4.49	neutral	0.28	neutral	-0.45	neutral_impact	0.34	0.69	neutral	0.98	neutral	1.10	11.23	neutral	0.32	0.5	NA	NA	0.08	neutral	0.27	neutral	0.22	neutral	6	1	deleterious	0.5	deleterious	-2	neutral	0.68	deleterious	-3.54	low_impact	1.88	high_impact	-0.79	medium_impact	0.48	0.8	37.04	8.79	0.37	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11277	11277	C	G	MI.17417	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	518	173	S	W	tCa/tGa	-1.32	0	0	probably_damaging	1	deleterious	0.01	neutral	4.32	deleterious	-7.03	deleterious	-4.34	medium_impact	2.98	0.64	neutral	0.12	damaging	4.28	24.00	deleterious	0.07	0.35	NA	NA	0.88	disease	0.74	disease	0.82	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.92	medium_impact	1.82	medium_impact	0.08	0.8	37.04	8.79	0.27	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11277	11277	C	T	MI.17418	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	518	173	S	L	tCa/tTa	-1.32	0	0	probably_damaging	1	neutral	0.07	neutral	4.39	deleterious	-3.53	deleterious	-3.57	medium_impact	2.48	0.72	neutral	0.19	damaging	4.59	24.40	deleterious	0.05	0.35	NA	NA	0.82	disease	0.65	disease	0.71	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.43	medium_impact	1.33	medium_impact	0.31	0.8	37.04	8.79	0.33	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11279	11279	C	G	MI.17419	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	520	174	L	V	Cta/Gta	-9.16	0	0	possibly_damaging	0.89	neutral	0.08	neutral	4.5	neutral	-0.87	neutral	-2.14	medium_impact	2.56	0.73	neutral	0.54	neutral	3.37	22.90	deleterious	0.35	0.5	NA	NA	0.44	neutral	0.5	neutral	0.22	neutral	6	0.97	neutral	0.1	neutral	0	NA	0.78	deleterious	-1.57	low_impact	-0.39	medium_impact	1.41	medium_impact	0.61	0.8	43.36	8.24	0.43	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8505	8505	A	T	MI.1742	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	140	47	Y	F	tAt/tTt	-0.57	0	0	benign	0	neutral	0.68	neutral	2.7	neutral	2.79	neutral	-1.96	neutral_impact	0	1	neutral	0.87	neutral	-0.72	0.06	neutral	0.45432647	0.85	0.35	neutral	0.05	neutral	0.28	neutral	0.04	neutral	9	0.32	neutral	0.84	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	0.48	medium_impact	-1.1	low_impact	0.34	0.85	NA	NA	0.45	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11279	11279	C	A	MI.17420	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	520	174	L	M	Cta/Ata	-9.16	0	0	probably_damaging	0.99	neutral	0.16	neutral	4.35	deleterious	-3.08	neutral	-1.36	medium_impact	2.17	0.8	neutral	0.59	neutral	3.70	23.30	deleterious	0.32	0.5	NA	NA	0.4	neutral	0.3	neutral	0.19	neutral	6	0.99	deleterious	0.09	neutral	1	deleterious	0.76	deleterious	-2.59	low_impact	-0.2	medium_impact	1.02	medium_impact	0.53	0.8	43.36	8.24	0.4	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11280	11280	T	A	MI.17421	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	521	174	L	Q	cTa/cAa	-0.63	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.33	deleterious	-4.22	deleterious	-4.4	high_impact	3.58	0.7	neutral	0.37	neutral	4.12	23.80	deleterious	0.03	0.35	NA	NA	0.77	disease	0.62	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.31	low_impact	-0.92	medium_impact	2.42	high_impact	0.19	0.8	43.36	8.24	0.36	N	0.88	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11280	11280	T	C	MI.17422	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	521	174	L	P	cTa/cCa	-0.63	0	0	probably_damaging	0.98	deleterious	0.03	neutral	4.32	deleterious	-4.62	deleterious	-5.17	medium_impact	2.95	0.63	neutral	0.53	neutral	3.89	23.50	deleterious	0.02	0.35	NA	NA	0.76	disease	0.56	disease	0.53	disease	1	1	deleterious	0.03	neutral	5	deleterious	0.89	deleterious	-2.31	low_impact	-0.64	medium_impact	1.79	medium_impact	0.11	0.8	43.36	8.24	0.35	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	COSM1472303	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11280	11280	T	G	MI.17423	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	521	174	L	R	cTa/cGa	-0.63	0	0	probably_damaging	0.98	deleterious	0.03	neutral	4.33	deleterious	-4.04	deleterious	-4.44	medium_impact	3.37	0.62	neutral	0.32	neutral	4.11	23.70	deleterious	0.02	0.35	NA	NA	0.83	disease	0.75	disease	0.79	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.89	deleterious	-2.31	low_impact	-0.64	medium_impact	2.21	high_impact	0.07	0.8	43.36	8.24	0.36	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11282	11282	A	G	MI.17424	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	523	175	N	D	Aac/Gac	-1.32	0	0	possibly_damaging	0.74	neutral	0.29	neutral	4.61	neutral	-0.36	deleterious	-2.66	low_impact	1.57	0.73	neutral	0.39	neutral	3.76	23.30	deleterious	0.47	0.55	0.4	neutral	0.48	neutral	0.56	disease	0.49	neutral	0	0.81	neutral	0.28	neutral	-3	neutral	0.70	deleterious	-1.14	low_impact	-0.02	medium_impact	0.43	medium_impact	0.21	0.8	17.43	20.8	0.38	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11282	11282	A	C	MI.17425	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	523	175	N	H	Aac/Cac	-1.32	0	0	probably_damaging	0.98	neutral	0.54	neutral	4.53	deleterious	-3.21	neutral	-2.08	medium_impact	2.66	0.72	neutral	0.77	neutral	1.81	15.04	deleterious	0.26	0.45	0.64	disease	0.34	neutral	0.39	neutral	0.62	disease	2	0.98	deleterious	0.28	neutral	1	deleterious	0.73	deleterious	-2.31	low_impact	0.24	medium_impact	1.51	medium_impact	0.18	0.8	17.43	20.8	0.34	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11282	11282	A	T	MI.17426	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	523	175	N	Y	Aac/Tac	-1.32	0	0	probably_damaging	0.98	neutral	1	neutral	4.52	deleterious	-4.04	deleterious	-4.13	medium_impact	2.32	0.8	neutral	0.61	neutral	3.67	23.30	deleterious	0.07	0.35	0.77	disease	0.56	disease	0.36	neutral	0.54	disease	1	0.98	deleterious	0.51	deleterious	1	deleterious	0.78	deleterious	-2.31	low_impact	1.88	high_impact	1.17	medium_impact	0.13	0.8	17.43	20.8	0.2	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11283	11283	A	G	MI.17427	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	524	175	N	S	aAc/aGc	1.91	0.91	0	benign	0.2	neutral	0.92	neutral	4.68	neutral	-0.68	neutral	-1.79	neutral_impact	0.52	0.6	neutral	0.71	neutral	0.23	4.98	deleterious	0.51	0.6	0.45	neutral	0.06	neutral	0.21	neutral	0.26	neutral	5	0.1	neutral	0.86	deleterious	-6	neutral	0.66	deleterious	-0.15	medium_impact	0.8	medium_impact	-0.61	medium_impact	0.14	0.8	17.43	20.8	0.36	N	0.92	polymorphism	1	0.02	.	.	.	.	.	.	COSM6716751	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11283	11283	A	T	MI.17428	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	524	175	N	I	aAc/aTc	1.91	0.91	0	probably_damaging	0.96	neutral	0.41	neutral	4.52	deleterious	-4.21	deleterious	-5.01	medium_impact	2.25	0.75	neutral	0.52	neutral	3.76	23.30	deleterious	0.07	0.35	0.73	disease	0.6	disease	0.54	disease	0.58	disease	2	0.96	neutral	0.23	neutral	1	deleterious	0.76	deleterious	-2.01	low_impact	0.11	medium_impact	1.1	medium_impact	0.09	0.8	17.43	20.8	0.38	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11283	11283	A	C	MI.17429	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	524	175	N	T	aAc/aCc	1.91	0.91	0	possibly_damaging	0.74	neutral	0.38	neutral	4.55	neutral	-1.4	deleterious	-2.97	low_impact	1.29	0.75	neutral	0.65	neutral	3.30	22.90	deleterious	0.21	0.45	0.52	disease	0.36	neutral	0.28	neutral	0.38	neutral	2	0.76	neutral	0.32	neutral	-3	neutral	0.69	deleterious	-1.14	low_impact	0.08	medium_impact	0.15	medium_impact	0.23	0.8	17.43	20.8	0.36	N	0.78	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8507	8507	A	C	MI.1743	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	142	48	N	H	Aac/Cac	-6.58	0	0	possibly_damaging	0.46	neutral	0.57	neutral	1.95	neutral	-1.2	neutral	-2.4	low_impact	1.36	1	neutral	0.78	neutral	1.35	12.53	neutral	0.67759194	0.85	0.32	neutral	0.11	neutral	0.3	neutral	0.06	neutral	9	0.42	neutral	0.56	deleterious	-3	neutral	0.37	neutral	-0.69	medium_impact	0.36	medium_impact	0.07	medium_impact	0.71	0.85	NA	NA	0.38	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11284	11284	C	G	MI.17430	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	525	175	N	K	aaC/aaG	4.9	0.94	0	possibly_damaging	0.83	neutral	0.25	neutral	4.58	neutral	-1.94	deleterious	-3.12	medium_impact	2.59	0.72	neutral	0.35	neutral	3.93	23.50	deleterious	0.27	0.45	0.18	neutral	0.58	disease	0.66	disease	0.72	disease	4	0.88	neutral	0.21	neutral	0	NA	0.69	deleterious	-1.37	low_impact	-0.07	medium_impact	1.44	medium_impact	0.32	0.8	17.43	20.8	0.53	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11284	11284	C	A	MI.17431	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	525	175	N	K	aaC/aaA	4.9	0.94	0	possibly_damaging	0.83	neutral	0.25	neutral	4.58	neutral	-1.94	deleterious	-3.12	medium_impact	2.59	0.72	neutral	0.35	neutral	4.43	24.20	deleterious	0.27	0.45	0.18	neutral	0.58	disease	0.66	disease	0.72	disease	4	0.88	neutral	0.21	neutral	0	NA	0.69	deleterious	-1.37	low_impact	-0.07	medium_impact	1.44	medium_impact	0.32	0.8	17.43	20.8	0.53	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11285	11285	A	G	MI.17432	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	526	176	I	V	Att/Gtt	-4.78	0	0	benign	0.18	neutral	0.17	neutral	4.56	neutral	-0.75	neutral	-0.57	low_impact	1.74	0.76	neutral	0.73	neutral	2.79	21.30	deleterious	0.38	0.5	0.24	neutral	0.13	neutral	0.56	disease	0.31	neutral	4	0.8	neutral	0.5	deleterious	-6	neutral	0.56	deleterious	-0.1	medium_impact	-0.18	medium_impact	0.6	medium_impact	0.39	0.8	26.8	28.07	0.47	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11285	11285	A	T	MI.17433	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	526	176	I	F	Att/Ttt	-4.78	0	0	benign	0.03	neutral	1	neutral	4.87	neutral	1.18	neutral	0.9	neutral_impact	-0.69	0.72	neutral	0.98	neutral	1.51	13.37	neutral	0.16	0.45	0.37	neutral	0.24	neutral	0.23	neutral	0.44	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.64	deleterious	0.7	medium_impact	1.88	high_impact	-1.81	low_impact	0.52	0.8	26.8	28.07	0.3	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11285	11285	A	C	MI.17434	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	526	176	I	L	Att/Ctt	-4.78	0	0	benign	0.01	neutral	0.81	neutral	4.69	neutral	0.34	neutral	0.19	neutral_impact	-0.14	0.71	neutral	0.97	neutral	1.22	11.87	neutral	0.27	0.45	0.32	neutral	0.12	neutral	0.14	neutral	0.26	neutral	5	0.16	neutral	0.9	deleterious	-6	neutral	0.58	deleterious	1.16	medium_impact	0.56	medium_impact	-1.26	low_impact	0.48	0.8	26.8	28.07	0.43	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11286	11286	T	G	MI.17435	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	527	176	I	S	aTt/aGt	-2.24	0	0	benign	0.37	neutral	0.14	neutral	4.48	neutral	-2.42	neutral	-2.3	low_impact	1.34	0.78	neutral	0.72	neutral	4.23	23.90	deleterious	0.02	0.35	0.48	neutral	0.5	disease	0.56	disease	0.63	disease	3	0.84	neutral	0.39	neutral	-6	neutral	0.70	deleterious	-0.5	medium_impact	-0.24	medium_impact	0.2	medium_impact	0.19	0.8	26.8	28.07	0.32	N	0.54	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11286	11286	T	C	MI.17436	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	527	176	I	T	aTt/aCt	-2.24	0	0	benign	0.03	neutral	0.09	neutral	4.51	neutral	-1.48	neutral	-2	low_impact	0.87	0.68	neutral	0.85	neutral	2.12	16.96	deleterious	0.06	0.35	0.45	neutral	0.27	neutral	0.32	neutral	0.45	neutral	1	0.91	neutral	0.53	deleterious	-6	neutral	0.67	deleterious	0.7	medium_impact	-0.36	medium_impact	-0.27	medium_impact	0.20	0.8	26.8	28.07	0.48	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11286	11286	T	A	MI.17437	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	527	176	I	N	aTt/aAt	-2.24	0	0	possibly_damaging	0.7	neutral	0.05	neutral	4.45	deleterious	-3.65	deleterious	-3.07	medium_impact	2.23	0.69	neutral	0.5	neutral	4.35	24.10	deleterious	0.07	0.35	0.45	neutral	0.59	disease	0.56	disease	0.69	disease	4	0.96	neutral	0.18	neutral	0	NA	0.72	deleterious	-1.06	low_impact	-0.52	medium_impact	1.08	medium_impact	0.17	0.8	26.8	28.07	0.4	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11287	11287	T	A	MI.17438	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	528	176	I	M	atT/atA	3.06	0.15	0.01	benign	0.12	neutral	0.85	neutral	4.48	neutral	-2.34	neutral	0.31	neutral_impact	-0.08	0.7	neutral	0.85	neutral	0.98	10.54	neutral	0.24	0.45	0.55	disease	0.1	neutral	0.17	neutral	0.3	neutral	4	0.06	neutral	0.87	deleterious	-6	neutral	0.65	deleterious	0.1	medium_impact	0.62	medium_impact	-1.21	low_impact	0.58	0.8	26.8	28.07	0.4	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11287	11287	T	G	MI.17439	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	528	176	I	M	atT/atG	3.06	0.15	0.01	benign	0.12	neutral	0.85	neutral	4.48	neutral	-2.34	neutral	0.31	neutral_impact	-0.08	0.7	neutral	0.85	neutral	0.63	8.35	deleterious	0.24	0.45	0.55	disease	0.1	neutral	0.17	neutral	0.3	neutral	4	0.06	neutral	0.87	deleterious	-6	neutral	0.65	deleterious	0.1	medium_impact	0.62	medium_impact	-1.21	low_impact	0.58	0.8	26.8	28.07	0.39	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8507	8507	A	G	MI.1744	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	142	48	N	D	Aac/Gac	-6.58	0	0	benign	0.12	neutral	0.38	neutral	1.96	neutral	-0.79	deleterious	-2.58	low_impact	1.57	1	neutral	0.9	neutral	0.86	9.80	deleterious	0.73708172	0.85	0.28	neutral	0.16	neutral	0.4	neutral	0.13	neutral	7	0.56	neutral	0.63	deleterious	-6	neutral	0.18	neutral	0.07	medium_impact	0.17	medium_impact	0.25	medium_impact	0.69	0.85	NA	NA	0.47	N	0.47	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11288	11288	C	G	MI.17440	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	529	177	L	V	Cta/Gta	-10.78	0	0	benign	0.01	neutral	0.42	neutral	4.59	neutral	-1.08	neutral	-1.49	low_impact	1.84	0.85	neutral	0.71	neutral	1.36	12.58	neutral	0.33	0.5	0.33	neutral	0.25	neutral	0.32	neutral	0.46	neutral	1	0.57	neutral	0.71	deleterious	-6	neutral	0.15	neutral	1.16	medium_impact	0.12	medium_impact	0.69	medium_impact	0.44	0.8	26.58	26.6	0.4	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11288	11288	C	A	MI.17441	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	529	177	L	M	Cta/Ata	-10.78	0	0	benign	0.03	neutral	0.23	neutral	4.57	neutral	-1.8	neutral	-0.88	low_impact	0.88	0.77	neutral	0.93	neutral	0.55	7.80	deleterious	0.28	0.45	0.52	disease	0.2	neutral	0.18	neutral	0.31	neutral	4	0.76	neutral	0.6	deleterious	-6	neutral	0.16	neutral	0.7	medium_impact	-0.09	medium_impact	-0.26	medium_impact	0.42	0.8	26.58	26.6	0.47	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11289	11289	T	C	MI.17442	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	530	177	L	P	cTa/cCa	-3.86	0	0	benign	0.02	neutral	0.35	neutral	4.61	neutral	-0.45	deleterious	-4.15	neutral_impact	0.78	0.78	neutral	0.8	neutral	1.11	11.28	neutral	0.04	0.35	0.72	disease	0.6	disease	0.36	neutral	0.5	neutral	0	0.64	neutral	0.67	deleterious	-6	neutral	0.56	deleterious	0.87	medium_impact	0.05	medium_impact	-0.35	medium_impact	0.11	0.8	26.58	26.6	0.27	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11289	11289	T	A	MI.17443	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	530	177	L	Q	cTa/cAa	-3.86	0	0	possibly_damaging	0.55	neutral	0.28	neutral	4.63	neutral	-0.19	deleterious	-3.66	low_impact	1.75	0.73	neutral	0.42	neutral	2.33	18.39	deleterious	0.05	0.35	0.65	disease	0.64	disease	0.36	neutral	0.49	neutral	0	0.71	neutral	0.37	neutral	-3	neutral	0.52	deleterious	-0.8	medium_impact	-0.03	medium_impact	0.61	medium_impact	0.12	0.8	26.58	26.6	0.35	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11289	11289	T	G	MI.17444	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	530	177	L	R	cTa/cGa	-3.86	0	0	possibly_damaging	0.47	neutral	0.3	neutral	4.63	neutral	-0.24	deleterious	-3.8	medium_impact	2.99	0.7	neutral	0.35	neutral	2.42	18.95	deleterious	0.03	0.35	0.49	neutral	0.73	disease	0.5	neutral	0.52	disease	0	0.67	neutral	0.42	neutral	0	NA	0.50	deleterious	-0.67	medium_impact	0	medium_impact	1.83	medium_impact	0.11	0.8	26.58	26.6	0.35	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11291	11291	C	G	MI.17445	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	532	178	L	V	Cta/Gta	-5.01	0	0	benign	0.4	neutral	0.23	neutral	4.59	neutral	-0.91	neutral	-0.52	low_impact	1.57	0.75	neutral	0.99	neutral	1.36	12.57	neutral	0.32	0.5	0.25	neutral	0.19	neutral	0.23	neutral	0.38	neutral	2	0.73	neutral	0.42	neutral	-6	neutral	0.62	deleterious	-0.55	medium_impact	-0.09	medium_impact	0.43	medium_impact	0.36	0.8	17.21	12.29	0.53	P	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11291	11291	C	A	MI.17446	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	532	178	L	M	Cta/Ata	-5.01	0	0	probably_damaging	0.93	neutral	0.39	neutral	4.56	neutral	-2.58	neutral	-0.54	neutral_impact	0.7	0.74	neutral	0.98	neutral	2.16	17.25	deleterious	0.27	0.45	0.3	neutral	0.12	neutral	0.19	neutral	0.31	neutral	4	0.93	neutral	0.23	neutral	-2	neutral	0.63	deleterious	-1.77	low_impact	0.09	medium_impact	-0.43	medium_impact	0.40	0.8	17.21	12.29	0.52	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11292	11292	T	C	MI.17447	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	533	178	L	P	cTa/cCa	-3.17	0	0	probably_damaging	0.95	deleterious	0.02	neutral	4.57	neutral	-1.55	deleterious	-3.33	medium_impact	3.1	0.66	neutral	0.43	neutral	2.65	20.50	deleterious	0.03	0.35	0.34	neutral	0.78	disease	0.66	disease	0.75	disease	5	1	deleterious	0.04	neutral	5	deleterious	0.74	deleterious	-1.92	low_impact	-0.75	medium_impact	1.94	medium_impact	0.13	0.8	17.21	12.29	0.36	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11292	11292	T	A	MI.17448	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	533	178	L	Q	cTa/cAa	-3.17	0	0	probably_damaging	0.95	deleterious	0.03	neutral	4.62	neutral	-0.41	deleterious	-2.92	medium_impact	3.1	0.74	neutral	0.56	neutral	2.84	21.60	deleterious	0.05	0.35	0.59	disease	0.57	disease	0.5	neutral	0.5	neutral	0	0.99	deleterious	0.04	neutral	5	deleterious	0.71	deleterious	-1.92	low_impact	-0.64	medium_impact	1.94	medium_impact	0.12	0.8	17.21	12.29	0.4	N	0.67	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11292	11292	T	G	MI.17449	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	533	178	L	R	cTa/cGa	-3.17	0	0	probably_damaging	0.93	deleterious	0.04	neutral	4.62	neutral	-0.39	deleterious	-3.06	medium_impact	3.44	0.71	neutral	0.49	neutral	2.72	20.90	deleterious	0.03	0.35	0.57	disease	0.7	disease	0.64	disease	0.72	disease	4	0.99	deleterious	0.06	neutral	5	deleterious	0.76	deleterious	-1.77	low_impact	-0.57	medium_impact	2.28	high_impact	0.15	0.8	17.21	12.29	0.41	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8507	8507	A	T	MI.1745	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	142	48	N	Y	Aac/Tac	-6.58	0	0	benign	0.38	neutral	1	neutral	1.92	neutral	-2.92	deleterious	-4.05	medium_impact	2.46	1	neutral	0.6	neutral	0.90	10.10	neutral	0.45194317	0.85	0.53	disease	0.26	neutral	0.33	neutral	0.14	neutral	7	0.38	neutral	0.81	deleterious	-3	neutral	0.40	neutral	-0.55	medium_impact	1.98	high_impact	1.01	medium_impact	0.61	0.85	NA	NA	0.28	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11294	11294	C	T	MI.17450	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	535	179	L	F	Ctc/Ttc	-12.39	0	0	probably_damaging	0.98	neutral	0.23	neutral	4.31	deleterious	-3.22	neutral	-1.32	neutral_impact	0.78	0.75	neutral	0.79	neutral	2.84	21.60	deleterious	0.16	0.45	0.35	neutral	0.36	neutral	0.23	neutral	0.47	neutral	1	0.98	deleterious	0.13	neutral	-2	neutral	0.67	deleterious	-2.31	low_impact	-0.09	medium_impact	-0.35	medium_impact	0.50	0.8	20.48	18.56	0.38	N	0.17	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11294	11294	C	G	MI.17451	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	535	179	L	V	Ctc/Gtc	-12.39	0	0	possibly_damaging	0.9	neutral	0.09	neutral	4.42	neutral	-1.38	neutral	-1.13	low_impact	1.64	0.8	neutral	0.57	neutral	3.35	22.90	deleterious	0.24	0.45	0.32	neutral	0.28	neutral	0.23	neutral	0.47	neutral	1	0.97	neutral	0.1	neutral	-3	neutral	0.65	deleterious	-1.61	low_impact	-0.36	medium_impact	0.5	medium_impact	0.52	0.8	20.48	18.56	0.46	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11294	11294	C	A	MI.17452	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	535	179	L	I	Ctc/Atc	-12.39	0	0	possibly_damaging	0.9	neutral	0.37	neutral	4.56	neutral	-0.42	neutral	-0.58	neutral_impact	0.74	0.76	neutral	0.98	neutral	2.52	19.58	deleterious	0.27	0.45	0.26	neutral	0.14	neutral	0.17	neutral	0.3	neutral	4	0.9	neutral	0.24	neutral	-3	neutral	0.64	deleterious	-1.61	low_impact	0.07	medium_impact	-0.39	medium_impact	0.55	0.8	20.48	18.56	0.51	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11295	11295	T	G	MI.17453	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	536	179	L	R	cTc/cGc	-7.09	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.29	deleterious	-4.11	deleterious	-3.33	medium_impact	3.34	0.63	neutral	0.13	damaging	4.14	23.80	deleterious	0.02	0.35	0.57	disease	0.76	disease	0.64	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-2.31	low_impact	-0.92	medium_impact	2.18	high_impact	0.22	0.8	20.48	18.56	0.26	N	0.87	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11295	11295	T	A	MI.17454	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	536	179	L	H	cTc/cAc	-7.09	0	0	probably_damaging	1	deleterious	0.01	neutral	4.28	deleterious	-4.68	deleterious	-3.33	medium_impact	2.98	0.74	neutral	0.3	neutral	4.22	23.90	deleterious	0.04	0.35	0.67	disease	0.68	disease	0.59	disease	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-3.54	low_impact	-0.92	medium_impact	1.82	medium_impact	0.18	0.8	20.48	18.56	0.3	N	0.82	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11295	11295	T	C	MI.17455	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	536	179	L	P	cTc/cCc	-7.09	0	0	probably_damaging	1	deleterious	0	neutral	4.32	neutral	-2.97	deleterious	-3.71	medium_impact	2.79	0.63	neutral	0.19	damaging	3.93	23.50	deleterious	0.02	0.35	0.68	disease	0.8	disease	0.65	disease	0.71	disease	4	1	deleterious	0	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	1.63	medium_impact	0.10	0.8	20.48	18.56	0.26	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11297	11297	A	T	MI.17456	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	538	180	T	S	Act/Tct	-11.24	0	0	benign	0.03	neutral	1	neutral	4.68	neutral	-0.17	neutral	0.18	neutral_impact	0	0.76	neutral	0.98	neutral	0.08	3.42	deleterious	0.39	0.5	0.24	neutral	0.21	neutral	0.14	neutral	0.36	neutral	3	0.03	neutral	0.99	deleterious	-6	neutral	0.27	neutral	0.7	medium_impact	1.88	high_impact	-1.13	low_impact	0.50	0.8	36.17	34.14	0.4	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11297	11297	A	C	MI.17457	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	538	180	T	P	Act/Cct	-11.24	0	0	possibly_damaging	0.72	neutral	0.29	neutral	4.59	neutral	-1.91	neutral	-0.52	neutral_impact	0.61	0.73	neutral	0.98	neutral	1.93	15.78	deleterious	0.09	0.35	0.74	disease	0.66	disease	0.3	neutral	0.53	disease	1	0.79	neutral	0.29	neutral	-3	neutral	0.70	deleterious	-1.1	low_impact	-0.02	medium_impact	-0.52	medium_impact	0.35	0.8	36.17	34.14	0.4	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11297	11297	A	G	MI.17458	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	538	180	T	A	Act/Gct	-11.24	0	0	benign	0.02	neutral	0.71	neutral	4.68	neutral	0.94	neutral	-0.59	low_impact	1.07	0.82	neutral	0.9	neutral	0.55	7.83	deleterious	0.3	0.45	0.48	neutral	0.25	neutral	0.29	neutral	0.42	neutral	2	0.26	neutral	0.85	deleterious	-6	neutral	0.37	neutral	0.87	medium_impact	0.42	medium_impact	-0.07	medium_impact	0.28	0.8	36.17	34.14	0.32	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11298	11298	C	A	MI.17459	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	539	180	T	N	aCt/aAt	-0.17	0	0	benign	0.03	neutral	0.59	neutral	4.67	neutral	-1.06	neutral	-0.01	neutral_impact	0.64	0.72	neutral	0.95	neutral	0.32	5.92	deleterious	0.28	0.45	0.55	disease	0.4	neutral	0.17	neutral	0.59	disease	2	0.37	neutral	0.78	deleterious	-6	neutral	0.18	neutral	0.7	medium_impact	0.29	medium_impact	-0.49	medium_impact	0.50	0.8	36.17	34.14	0.41	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8508	8508	A	G	MI.1746	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	143	48	N	S	aAc/aGc	-5.66	0	0	benign	0.05	neutral	0.66	neutral	2.03	neutral	0.35	neutral	-1.69	low_impact	0.96	1	neutral	0.86	neutral	-0.07	1.95	neutral	0.70300388	0.85	0.15	neutral	0.14	neutral	0.35	neutral	0.11	neutral	8	0.27	neutral	0.81	deleterious	-6	neutral	0.12	neutral	0.46	medium_impact	0.45	medium_impact	-0.28	medium_impact	0.45	0.85	NA	NA	0.36	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11298	11298	C	G	MI.17460	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	539	180	T	S	aCt/aGt	-0.17	0	0	benign	0.03	neutral	1	neutral	4.68	neutral	-0.17	neutral	0.18	neutral_impact	0	0.76	neutral	0.98	neutral	0.29	5.60	deleterious	0.39	0.5	0.24	neutral	0.21	neutral	0.14	neutral	0.36	neutral	3	0.03	neutral	0.99	deleterious	-6	neutral	0.27	neutral	0.7	medium_impact	1.88	high_impact	-1.13	low_impact	0.50	0.8	36.17	34.14	0.35	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11298	11298	C	T	MI.17461	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	539	180	T	I	aCt/aTt	-0.17	0	0	possibly_damaging	0.49	neutral	0.32	neutral	4.66	neutral	-1.6	neutral	-1.64	neutral_impact	0.78	0.79	neutral	0.7	neutral	3.57	23.20	deleterious	0.17	0.45	0.59	disease	0.43	neutral	0.31	neutral	0.62	disease	2	0.65	neutral	0.42	neutral	-3	neutral	0.63	deleterious	-0.7	medium_impact	0.02	medium_impact	-0.35	medium_impact	0.43	0.8	36.17	34.14	0.37	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11300	11300	C	G	MI.17462	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	541	181	L	V	Ctc/Gtc	-4.32	0	0	benign	0.12	neutral	0.13	neutral	4.54	neutral	-1.39	neutral	-0.71	neutral_impact	0.78	0.78	neutral	0.68	neutral	3.37	22.90	deleterious	0.41	0.5	0.29	neutral	0.28	neutral	0.35	neutral	0.44	neutral	1	0.85	neutral	0.51	deleterious	-6	neutral	0.65	deleterious	0.1	medium_impact	-0.26	medium_impact	-0.35	medium_impact	0.29	0.8	28.76	24.53	0.41	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11300	11300	C	A	MI.17463	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	541	181	L	I	Ctc/Atc	-4.32	0	0	benign	0.12	neutral	0.22	neutral	4.51	neutral	-2.7	neutral	-0.38	neutral_impact	0.52	0.79	neutral	0.98	neutral	2.77	21.20	deleterious	0.33	0.5	0.22	neutral	0.3	neutral	0.18	neutral	0.45	neutral	1	0.75	neutral	0.55	deleterious	-6	neutral	0.64	deleterious	0.1	medium_impact	-0.11	medium_impact	-0.61	medium_impact	0.49	0.8	28.76	24.53	0.54	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11300	11300	C	T	MI.17464	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	541	181	L	F	Ctc/Ttc	-4.32	0	0	probably_damaging	0.94	neutral	0.6	neutral	4.51	neutral	-2.48	neutral	1.27	neutral_impact	0.74	0.75	neutral	0.97	neutral	2.40	18.81	deleterious	0.36	0.5	0.49	neutral	0.27	neutral	0.18	neutral	0.41	neutral	2	0.93	neutral	0.33	neutral	-2	neutral	0.68	deleterious	-1.84	low_impact	0.3	medium_impact	-0.39	medium_impact	0.38	0.8	28.76	24.53	0.4	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11301	11301	T	A	MI.17465	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	542	181	L	H	cTc/cAc	-0.4	0	0	probably_damaging	0.98	neutral	0.2	neutral	4.51	neutral	-2.61	neutral	-0.16	medium_impact	2.04	0.77	neutral	0.96	neutral	2.77	21.20	deleterious	0.1	0.4	0.7	disease	0.58	disease	0.3	neutral	0.52	disease	0	0.99	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	-0.14	medium_impact	0.89	medium_impact	0.12	0.8	28.76	24.53	0.43	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11301	11301	T	C	MI.17466	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	542	181	L	P	cTc/cCc	-0.4	0	0	probably_damaging	0.98	neutral	0.07	neutral	4.5	neutral	-2.89	deleterious	-2.56	low_impact	0.88	0.57	damaging	0.44	neutral	3.84	23.40	deleterious	0.04	0.35	0.71	disease	0.81	disease	0.57	disease	0.74	disease	5	0.99	deleterious	0.05	neutral	-2	neutral	0.82	deleterious	-2.31	low_impact	-0.43	medium_impact	-0.26	medium_impact	0.16	0.8	28.76	24.53	0.31	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	COSM1155504	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11301	11301	T	G	MI.17467	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	542	181	L	R	cTc/cGc	-0.4	0	0	probably_damaging	0.96	neutral	0.08	neutral	4.57	neutral	-0.98	neutral	-1.91	medium_impact	2.04	0.64	neutral	0.48	neutral	4.12	23.80	deleterious	0.06	0.35	0.63	disease	0.76	disease	0.53	disease	0.67	disease	3	0.99	deleterious	0.06	neutral	1	deleterious	0.79	deleterious	-2.01	low_impact	-0.39	medium_impact	0.89	medium_impact	0.17	0.8	28.76	24.53	0.36	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11303	11303	A	T	MI.17468	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	544	182	T	S	Act/Tct	-5.01	0	0	benign	0.02	neutral	0.42	neutral	2.3	neutral	-0.17	neutral	-0.25	neutral_impact	-0.58	0.77	neutral	0.98	neutral	-0.47	0.26	neutral	0.46	0.55	0.38	neutral	0.12	neutral	0.18	neutral	0.31	neutral	4	0.56	neutral	0.7	deleterious	-6	neutral	0.11	neutral	0.87	medium_impact	0.12	medium_impact	-1.7	low_impact	0.57	0.8	33.12	36.91	0.51	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11303	11303	A	C	MI.17469	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	544	182	T	P	Act/Cct	-5.01	0	0	possibly_damaging	0.55	neutral	0.2	neutral	2.22	neutral	-1.81	neutral	-1.3	low_impact	0.95	0.7	neutral	0.67	neutral	1.76	14.77	neutral	0.09	0.35	0.61	disease	0.71	disease	0.51	disease	0.6	disease	2	0.79	neutral	0.33	neutral	-3	neutral	0.65	deleterious	-0.8	medium_impact	-0.14	medium_impact	-0.19	medium_impact	0.36	0.8	33.12	36.91	0.32	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8508	8508	A	C	MI.1747	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	143	48	N	T	aAc/aCc	-5.66	0	0	benign	0.05	neutral	0.58	neutral	2.08	neutral	0.92	neutral	-2.17	neutral_impact	0.44	1	neutral	0.95	neutral	0.34	6.09	deleterious	0.74487615	0.85	0.28	neutral	0.26	neutral	0.25	neutral	0.23	neutral	5	0.36	neutral	0.77	deleterious	-6	neutral	0.15	neutral	0.46	medium_impact	0.37	medium_impact	-0.72	medium_impact	0.59	0.85	NA	NA	0.36	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11303	11303	A	G	MI.17470	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	544	182	T	A	Act/Gct	-5.01	0	0	benign	0.12	neutral	0.5	neutral	2.34	neutral	0.48	neutral	-0.77	neutral_impact	0.6	0.76	neutral	0.86	neutral	-0.32	0.61	neutral	0.31	0.45	0.28	neutral	0.2	neutral	0.32	neutral	0.37	neutral	3	0.42	neutral	0.69	deleterious	-6	neutral	0.25	neutral	0.1	medium_impact	0.2	medium_impact	-0.53	medium_impact	0.33	0.8	33.12	36.91	0.36	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11304	11304	C	T	MI.17471	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	545	182	T	I	aCt/aTt	-1.09	0	0	benign	0.12	neutral	0.39	neutral	2.26	neutral	-1.32	neutral	-1.2	neutral_impact	-0.69	0.75	neutral	0.77	neutral	1.88	15.47	deleterious	0.22	0.45	0.18	neutral	0.4	neutral	0.21	neutral	0.44	neutral	1	0.55	neutral	0.64	deleterious	-6	neutral	0.53	deleterious	0.1	medium_impact	0.09	medium_impact	-1.81	low_impact	0.47	0.8	33.12	36.91	0.4	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11304	11304	C	A	MI.17472	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	545	182	T	N	aCt/aAt	-1.09	0	0	benign	0.38	neutral	0.32	neutral	2.27	neutral	-0.6	neutral	-0.68	neutral_impact	0.14	0.7	neutral	0.92	neutral	0.28	5.49	deleterious	0.39	0.5	0.56	disease	0.35	neutral	0.2	neutral	0.58	disease	2	0.62	neutral	0.47	deleterious	-6	neutral	0.40	neutral	-0.52	medium_impact	0.02	medium_impact	-0.99	medium_impact	0.48	0.8	33.12	36.91	0.46	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11304	11304	C	G	MI.17473	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	545	182	T	S	aCt/aGt	-1.09	0	0	benign	0.02	neutral	0.42	neutral	2.3	neutral	-0.17	neutral	-0.25	neutral_impact	-0.58	0.77	neutral	0.98	neutral	-0.26	0.83	neutral	0.46	0.55	0.38	neutral	0.12	neutral	0.18	neutral	0.31	neutral	4	0.56	neutral	0.7	deleterious	-6	neutral	0.11	neutral	0.87	medium_impact	0.12	medium_impact	-1.7	low_impact	0.57	0.8	33.12	36.91	0.53	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11306	11306	G	C	MI.17474	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	547	183	A	P	Gcc/Ccc	-5.7	0	0	possibly_damaging	0.55	neutral	0.28	neutral	2.02	deleterious	-3.6	neutral	-0.19	neutral_impact	0.52	0.73	neutral	0.75	neutral	1.74	14.64	neutral	0.07	0.35	0.74	disease	0.52	disease	0.24	neutral	0.47	neutral	1	0.71	neutral	0.37	neutral	-3	neutral	0.57	deleterious	-0.8	medium_impact	-0.03	medium_impact	-0.61	medium_impact	0.39	0.8	25.05	16.68	0.42	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11306	11306	G	T	MI.17475	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	547	183	A	S	Gcc/Tcc	-5.7	0	0	benign	0.02	neutral	0.49	neutral	2.1	neutral	-2.25	neutral	0.32	neutral_impact	-0.44	0.78	neutral	0.93	neutral	-0.74	0.06	neutral	0.37	0.5	0.27	neutral	0.19	neutral	0.13	neutral	0.35	neutral	3	0.49	neutral	0.74	deleterious	-6	neutral	0.11	neutral	0.87	medium_impact	0.19	medium_impact	-1.56	low_impact	0.40	0.8	25.05	16.68	0.44	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11306	11306	G	A	MI.17476	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	547	183	A	T	Gcc/Acc	-5.7	0	0	benign	0.01	neutral	0.45	neutral	2.06	neutral	-2.59	neutral	0.08	neutral_impact	-0.32	0.82	neutral	1	neutral	0.17	4.32	deleterious	0.29	0.45	0.41	neutral	0.18	neutral	0.13	neutral	0.36	neutral	3	0.54	neutral	0.72	deleterious	-6	neutral	0.23	neutral	1.16	medium_impact	0.15	medium_impact	-1.44	low_impact	0.60	0.8	25.05	16.68	0.48	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11307	11307	C	A	MI.17477	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	548	183	A	D	gCc/gAc	-5.93	0	0	benign	0.02	neutral	0.26	neutral	2.03	deleterious	-3.37	neutral	-0.67	neutral_impact	-0.06	0.75	neutral	0.69	neutral	0.59	8.06	deleterious	0.04	0.35	0.68	disease	0.53	disease	0.48	neutral	0.49	neutral	0	0.73	neutral	0.62	deleterious	-6	neutral	0.46	deleterious	0.87	medium_impact	-0.05	medium_impact	-1.19	low_impact	0.24	0.8	25.05	16.68	0.32	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11307	11307	C	G	MI.17478	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	548	183	A	G	gCc/gGc	-5.93	0	0	benign	0.01	neutral	0.38	neutral	2.08	neutral	-1.98	neutral	-1.03	neutral_impact	0.49	0.78	neutral	0.76	neutral	0.49	7.34	deleterious	0.36	0.5	0.67	disease	0.27	neutral	0.29	neutral	0.55	disease	1	0.61	neutral	0.69	deleterious	-6	neutral	0.27	neutral	1.16	medium_impact	0.08	medium_impact	-0.64	medium_impact	0.56	0.8	25.05	16.68	0.33	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11307	11307	C	T	MI.17479	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	548	183	A	V	gCc/gTc	-5.93	0	0	benign	0.26	neutral	0.51	neutral	2.08	neutral	-2.31	neutral	-0.55	neutral_impact	0.74	0.79	neutral	0.92	neutral	1.10	11.23	neutral	0.25	0.45	0.4	neutral	0.25	neutral	0.29	neutral	0.45	neutral	1	0.39	neutral	0.63	deleterious	-6	neutral	0.36	neutral	-0.29	medium_impact	0.21	medium_impact	-0.39	medium_impact	0.73	0.85	25.05	16.68	0.34	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8508	8508	A	T	MI.1748	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	143	48	N	I	aAc/aTc	-5.66	0	0	benign	0.05	neutral	0.45	neutral	1.92	neutral	-2.6	deleterious	-4.25	low_impact	1.57	1	neutral	0.87	neutral	1.96	15.94	deleterious	0.52090386	0.85	0.46	neutral	0.2	neutral	0.39	neutral	0.14	neutral	7	0.51	neutral	0.7	deleterious	-6	neutral	0.19	neutral	0.46	medium_impact	0.24	medium_impact	0.25	medium_impact	0.53	0.85	NA	NA	0.46	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11309	11309	C	G	MI.17480	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	550	184	Q	E	Caa/Gaa	-6.16	0	0	benign	0.18	neutral	0.28	neutral	2.29	neutral	-0.3	neutral	-0.62	neutral_impact	0.1	0.81	neutral	0.95	neutral	-0.16	1.30	neutral	0.29	0.45	0.23	neutral	0.46	neutral	0.35	neutral	0.44	neutral	1	0.67	neutral	0.55	deleterious	-6	neutral	0.17	neutral	-0.1	medium_impact	-0.03	medium_impact	-1.03	low_impact	0.33	0.8	31.59	22.1	0.38	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11309	11309	C	A	MI.17481	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	550	184	Q	K	Caa/Aaa	-6.16	0	0	benign	0.01	neutral	0.29	neutral	2.28	neutral	-0.48	neutral	-0.44	neutral_impact	-0.26	0.81	neutral	0.9	neutral	0.48	7.30	deleterious	0.26	0.45	0.23	neutral	0.48	neutral	0.36	neutral	0.44	neutral	1	0.7	neutral	0.64	deleterious	-6	neutral	0.15	neutral	1.16	medium_impact	-0.02	medium_impact	-1.38	low_impact	0.23	0.8	31.59	22.1	0.36	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11310	11310	A	C	MI.17482	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	551	184	Q	P	cAa/cCa	-0.86	0	0	benign	0.01	neutral	0.24	neutral	2.25	neutral	-0.74	neutral	-0.08	neutral_impact	0.03	0.74	neutral	0.93	neutral	-1.39	0.00	neutral	0.13	0.4	0.52	disease	0.25	neutral	0.43	neutral	0.36	neutral	3	0.75	neutral	0.62	deleterious	-6	neutral	0.19	neutral	1.16	medium_impact	-0.08	medium_impact	-1.1	low_impact	0.23	0.8	31.59	22.1	0.48	N	0.85	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11310	11310	A	T	MI.17483	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	551	184	Q	L	cAa/cTa	-0.86	0	0	benign	0.26	neutral	0.66	neutral	2.23	neutral	-1.28	neutral	-1.91	neutral_impact	-0.75	0.77	neutral	0.72	neutral	0.44	6.95	deleterious	0.11	0.4	0.4	neutral	0.5	disease	0.36	neutral	0.45	neutral	1	0.24	neutral	0.7	deleterious	-6	neutral	0.20	neutral	-0.29	medium_impact	0.36	medium_impact	-1.87	low_impact	0.12	0.8	31.59	22.1	0.22	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11310	11310	A	G	MI.17484	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	551	184	Q	R	cAa/cGa	-0.86	0	0	benign	0.01	neutral	0.35	neutral	2.24	neutral	-1.04	neutral	-1.02	neutral_impact	0.42	0.81	neutral	0.73	neutral	0.30	5.70	deleterious	0.36	0.5	0.32	neutral	0.52	disease	0.44	neutral	0.52	disease	0	0.64	neutral	0.67	deleterious	-6	neutral	0.18	neutral	1.16	medium_impact	0.05	medium_impact	-0.71	medium_impact	0.11	0.8	31.59	22.1	0.33	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11311	11311	A	C	MI.17485	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	552	184	Q	H	caA/caC	-0.4	0	0	benign	0.01	neutral	0.54	neutral	2.22	neutral	-1.52	neutral	-1.34	neutral_impact	0.58	0.79	neutral	0.92	neutral	0.48	7.26	deleterious	0.2	0.45	0.29	neutral	0.37	neutral	0.32	neutral	0.45	neutral	1	0.44	neutral	0.77	deleterious	-6	neutral	0.42	neutral	1.16	medium_impact	0.24	medium_impact	-0.55	medium_impact	0.29	0.8	31.59	22.1	0.3	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11311	11311	A	T	MI.17486	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	552	184	Q	H	caA/caT	-0.4	0	0	benign	0.01	neutral	0.54	neutral	2.22	neutral	-1.52	neutral	-1.34	neutral_impact	0.58	0.79	neutral	0.92	neutral	0.60	8.19	deleterious	0.2	0.45	0.29	neutral	0.37	neutral	0.32	neutral	0.45	neutral	1	0.44	neutral	0.77	deleterious	-6	neutral	0.42	neutral	1.16	medium_impact	0.24	medium_impact	-0.55	medium_impact	0.29	0.8	31.59	22.1	0.3	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11312	11312	G	A	MI.17487	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	553	185	E	K	Gaa/Aaa	-9.62	0	0	benign	0.01	neutral	0.91	neutral	4.62	neutral	-1.06	neutral	-0.04	neutral_impact	-0.37	0.81	neutral	0.66	neutral	0.42	6.79	deleterious	0.1	0.4	0.27	neutral	0.27	neutral	0.41	neutral	0.42	neutral	2	0.07	neutral	0.95	deleterious	-6	neutral	0.18	neutral	1.16	medium_impact	0.77	medium_impact	-1.49	low_impact	0.57	0.8	30.94	35.44	0.25	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11312	11312	G	C	MI.17488	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	553	185	E	Q	Gaa/Caa	-9.62	0	0	benign	0.26	neutral	0.69	neutral	4.65	neutral	-0.66	neutral	0.17	neutral_impact	-0.64	0.76	neutral	0.8	neutral	-0.38	0.42	neutral	0.55	0.6	0.33	neutral	0.13	neutral	0.2	neutral	0.28	neutral	4	0.22	neutral	0.72	deleterious	-6	neutral	0.26	neutral	-0.29	medium_impact	0.4	medium_impact	-1.76	low_impact	0.56	0.8	30.94	35.44	0.35	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11313	11313	A	T	MI.17489	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	554	185	E	V	gAa/gTa	-5.24	0	0	benign	0.34	neutral	0.67	neutral	4.63	neutral	-2.01	neutral	0.31	neutral_impact	-0.28	0.8	neutral	0.82	neutral	0.13	3.93	deleterious	0.22	0.45	0.44	neutral	0.18	neutral	0.4	neutral	0.34	neutral	3	0.27	neutral	0.67	deleterious	-6	neutral	0.29	neutral	-0.45	medium_impact	0.37	medium_impact	-1.4	low_impact	0.42	0.8	30.94	35.44	0.27	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8509	8509	C	G	MI.1749	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	144	48	N	K	aaC/aaG	-1.03	0	0	benign	0.09	neutral	0.64	neutral	2.04	neutral	0.57	neutral	-1.96	neutral_impact	-0.04	0.99	neutral	0.92	neutral	0.84	9.72	deleterious	0.78510221	0.85	0.17	neutral	0.22	neutral	0.28	neutral	0.17	neutral	7	0.27	neutral	0.78	deleterious	-6	neutral	0.17	neutral	0.2	medium_impact	0.43	medium_impact	-1.13	low_impact	0.69	0.85	NA	NA	0.42	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11313	11313	A	C	MI.17490	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	554	185	E	A	gAa/gCa	-5.24	0	0	benign	0.12	neutral	1	neutral	4.69	neutral	-0.6	neutral	0.19	neutral_impact	-0.42	0.78	neutral	0.94	neutral	-0.77	0.05	neutral	0.36	0.5	0.19	neutral	0.11	neutral	0.38	neutral	0.3	neutral	4	0.12	neutral	0.94	deleterious	-6	neutral	0.12	neutral	0.1	medium_impact	1.88	high_impact	-1.54	low_impact	0.28	0.8	30.94	35.44	0.29	N	0.28	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11313	11313	A	G	MI.17491	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	554	185	E	G	gAa/gGa	-5.24	0	0	benign	0.18	neutral	0.57	neutral	4.61	neutral	-1.35	neutral	-1.12	neutral_impact	-0.14	0.79	neutral	0.64	neutral	0.42	6.75	deleterious	0.32	0.5	0.45	neutral	0.16	neutral	0.47	neutral	0.31	neutral	4	0.32	neutral	0.7	deleterious	-6	neutral	0.15	neutral	-0.1	medium_impact	0.27	medium_impact	-1.26	low_impact	0.34	0.8	30.94	35.44	0.27	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11314	11314	A	T	MI.17492	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	555	185	E	D	gaA/gaT	-0.4	0	0.01	benign	0.01	neutral	0.64	neutral	4.59	neutral	-0.78	neutral	-0.5	neutral_impact	0.12	0.74	neutral	0.76	neutral	0.04	2.95	deleterious	0.6	0.65	0.36	neutral	0.16	neutral	0.31	neutral	0.29	neutral	4	0.34	neutral	0.82	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.34	medium_impact	-1.01	low_impact	0.63	0.8	30.94	35.44	0.36	N	0.41	polymorphism	1	0.01	rs386829128	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11314	11314	A	C	MI.17493	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	555	185	E	D	gaA/gaC	-0.4	0	0.01	benign	0.01	neutral	0.64	neutral	4.59	neutral	-0.78	neutral	-0.5	neutral_impact	0.12	0.74	neutral	0.76	neutral	-0.06	2.02	deleterious	0.6	0.65	0.36	neutral	0.16	neutral	0.31	neutral	0.29	neutral	4	0.34	neutral	0.82	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.34	medium_impact	-1.01	low_impact	0.63	0.8	30.94	35.44	0.36	N	0.41	polymorphism	1	0.01	rs386829128	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11315	11315	C	G	MI.17494	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	556	186	L	V	Cta/Gta	-8.24	0	0.01	possibly_damaging	0.53	neutral	0.44	neutral	4.62	neutral	-1.87	neutral	-1	neutral_impact	0.79	0.78	neutral	0.85	neutral	1.95	15.89	deleterious	0.43	0.55	0.36	neutral	0.21	neutral	0.37	neutral	0.36	neutral	3	0.56	neutral	0.46	neutral	-3	neutral	0.66	deleterious	-0.77	medium_impact	0.14	medium_impact	-0.34	medium_impact	0.21	0.8	13.73	12.89	0.35	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11315	11315	C	A	MI.17495	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	556	186	L	M	Cta/Ata	-8.24	0	0.01	benign	0.4	neutral	0.31	neutral	4.59	neutral	-2.75	neutral	-0.42	neutral_impact	0.69	0.77	neutral	0.98	neutral	2.41	18.87	deleterious	0.37	0.5	0.45	neutral	0.14	neutral	0.23	neutral	0.31	neutral	4	0.64	neutral	0.46	neutral	-6	neutral	0.67	deleterious	-0.55	medium_impact	0.01	medium_impact	-0.44	medium_impact	0.51	0.8	13.73	12.89	0.45	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11316	11316	T	A	MI.17496	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	557	186	L	Q	cTa/cAa	-11.47	0	0	probably_damaging	0.93	neutral	0.35	neutral	4.5	deleterious	-4.46	neutral	-1.93	neutral_impact	-0.27	0.76	neutral	0.86	neutral	2.90	21.90	deleterious	0.14	0.4	0.76	disease	0.52	disease	0.3	neutral	0.52	disease	0	0.94	neutral	0.21	neutral	-2	neutral	0.77	deleterious	-1.77	low_impact	0.05	medium_impact	-1.39	low_impact	0.15	0.8	13.73	12.89	0.32	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11316	11316	T	C	MI.17497	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	557	186	L	P	cTa/cCa	-11.47	0	0	probably_damaging	0.95	neutral	0.29	neutral	4.49	deleterious	-4.02	deleterious	-2.75	neutral_impact	-0.69	0.75	neutral	0.8	neutral	2.72	20.90	deleterious	0.08	0.35	0.8	disease	0.66	disease	0.33	neutral	0.57	disease	1	0.96	neutral	0.17	neutral	-2	neutral	0.82	deleterious	-1.92	low_impact	-0.02	medium_impact	-1.81	low_impact	0.08	0.8	13.73	12.89	0.32	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11316	11316	T	G	MI.17498	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	557	186	L	R	cTa/cGa	-11.47	0	0	probably_damaging	0.93	neutral	0.32	neutral	4.51	deleterious	-4.24	neutral	-2.29	low_impact	1.54	0.67	neutral	0.39	neutral	2.92	21.90	deleterious	0.09	0.4	0.74	disease	0.73	disease	0.53	disease	0.65	disease	3	0.94	neutral	0.2	neutral	-2	neutral	0.82	deleterious	-1.77	low_impact	0.02	medium_impact	0.4	medium_impact	0.10	0.8	13.73	12.89	0.29	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11318	11318	T	A	MI.17499	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	559	187	S	T	Tca/Aca	-5.24	0	0.01	benign	0	neutral	0.42	neutral	4.64	neutral	-1.24	neutral	0.11	neutral_impact	-0.06	0.77	neutral	1	neutral	-0.16	1.35	neutral	0.52	0.6	0.3	neutral	0.14	neutral	0.2	neutral	0.27	neutral	5	0.58	neutral	0.71	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	0.12	medium_impact	-1.19	low_impact	0.50	0.8	30.72	19.66	0.49	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8608	8608	C	G	MI.175	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	82	28	P	A	Cct/Gct	-10.98	0	0	benign	0.18	neutral	0.22	neutral	4.47	neutral	2.52	neutral	0.89	neutral_impact	-1.1	0.89	neutral	0.93	neutral	-0.75	0.06	neutral	0.38	0.65	0.29	neutral	0.09	neutral	0.27	neutral	0.29	neutral	4	0.74	neutral	0.52	deleterious	-6	neutral	0.23	neutral	-0.13	medium_impact	-0.02	medium_impact	-2.04	low_impact	0.78	0.9	31.86	20.94	0.47	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8509	8509	C	A	MI.1750	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	144	48	N	K	aaC/aaA	-1.03	0	0	benign	0.09	neutral	0.64	neutral	2.04	neutral	0.57	neutral	-1.96	neutral_impact	-0.04	0.99	neutral	0.92	neutral	1.33	12.40	neutral	0.78510221	0.85	0.17	neutral	0.22	neutral	0.28	neutral	0.17	neutral	7	0.27	neutral	0.78	deleterious	-6	neutral	0.17	neutral	0.2	medium_impact	0.43	medium_impact	-1.13	low_impact	0.69	0.85	NA	NA	0.42	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11318	11318	T	C	MI.17500	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	559	187	S	P	Tca/Cca	-5.24	0	0.01	benign	0	neutral	0.23	neutral	4.59	neutral	-1.4	neutral	0.02	neutral_impact	0.74	0.78	neutral	1	neutral	0.46	7.12	deleterious	0.23	0.45	0.42	neutral	0.63	disease	0.23	neutral	0.43	neutral	1	0.77	neutral	0.62	deleterious	-6	neutral	0.19	neutral	2.1	high_impact	-0.09	medium_impact	-0.39	medium_impact	0.16	0.8	30.72	19.66	0.46	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11318	11318	T	G	MI.17501	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	559	187	S	A	Tca/Gca	-5.24	0	0.01	benign	0	neutral	0.51	neutral	4.66	neutral	-0.3	neutral	-0.37	low_impact	0.84	0.8	neutral	0.88	neutral	-0.26	0.83	neutral	0.46	0.55	0.33	neutral	0.24	neutral	0.31	neutral	0.44	neutral	1	0.49	neutral	0.76	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.21	medium_impact	-0.3	medium_impact	0.25	0.8	30.72	19.66	0.35	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11319	11319	C	T	MI.17502	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	560	187	S	L	tCa/tTa	-10.32	0	0	benign	0	neutral	0.76	neutral	4.73	neutral	-2.16	neutral	0.3	neutral_impact	-1.01	0.71	neutral	0.97	neutral	0.06	3.16	deleterious	0.21	0.45	0.19	neutral	0.27	neutral	0.23	neutral	0.43	neutral	1	0.24	neutral	0.88	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.48	medium_impact	-2.13	low_impact	0.23	0.8	30.72	19.66	0.41	N	0.38	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11319	11319	C	G	MI.17503	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	560	187	S	W	tCa/tGa	-10.32	0	0	possibly_damaging	0.59	neutral	0.19	neutral	4.56	deleterious	-5.68	neutral	-1.66	low_impact	1.11	0.77	neutral	0.39	neutral	1.33	12.40	neutral	0.1	0.4	0.77	disease	0.7	disease	0.51	disease	0.58	disease	2	0.81	neutral	0.3	neutral	-3	neutral	0.56	deleterious	-0.87	medium_impact	-0.15	medium_impact	-0.03	medium_impact	0.11	0.8	30.72	19.66	0.28	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11321	11321	A	G	MI.17504	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	562	188	N	D	Aac/Gac	-12.62	0	0	benign	0.01	neutral	0.66	neutral	4.55	neutral	-0.91	neutral	-0.95	neutral_impact	0.56	0.79	neutral	0.98	neutral	0.31	5.76	deleterious	0.89	0.9	0.52	disease	0.34	neutral	0.45	neutral	0.34	neutral	3	0.33	neutral	0.83	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.36	medium_impact	-0.57	medium_impact	0.19	0.8	29.41	21.06	0.33	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11321	11321	A	C	MI.17505	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	562	188	N	H	Aac/Cac	-12.62	0	0	possibly_damaging	0.68	neutral	0.46	neutral	4.47	neutral	-2.81	neutral	-0.99	low_impact	1.14	0.74	neutral	0.84	neutral	0.65	8.47	deleterious	0.73	0.75	0.57	disease	0.39	neutral	0.31	neutral	0.62	disease	2	0.67	neutral	0.39	neutral	-3	neutral	0.54	deleterious	-1.03	low_impact	0.16	medium_impact	0	medium_impact	0.04	0.8	29.41	21.06	0.36	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11321	11321	A	T	MI.17506	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	562	188	N	Y	Aac/Tac	-12.62	0	0	possibly_damaging	0.49	neutral	0.7	neutral	4.45	deleterious	-3.52	neutral	-1.44	low_impact	0.91	0.81	neutral	0.75	neutral	0.76	9.20	deleterious	0.21	0.45	0.45	neutral	0.52	disease	0.28	neutral	0.47	neutral	1	0.39	neutral	0.61	deleterious	-3	neutral	0.58	deleterious	-0.7	medium_impact	0.41	medium_impact	-0.23	medium_impact	0.10	0.8	29.41	21.06	0.25	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11322	11322	A	C	MI.17507	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	563	188	N	T	aAc/aCc	-9.39	0	0	benign	0	neutral	0.78	neutral	4.5	neutral	-1.68	neutral	-0.45	neutral_impact	0.58	0.81	neutral	1	neutral	-1.11	0.01	neutral	0.7	0.75	0.33	neutral	0.2	neutral	0.25	neutral	0.36	neutral	3	0.21	neutral	0.89	deleterious	-6	neutral	0.19	neutral	2.1	high_impact	0.51	medium_impact	-0.55	medium_impact	0.11	0.8	29.41	21.06	0.36	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11322	11322	A	T	MI.17508	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	563	188	N	I	aAc/aTc	-9.39	0	0	benign	0	neutral	0.43	neutral	4.51	neutral	-1.54	neutral	-1.56	neutral_impact	0.76	0.77	neutral	0.8	neutral	1.57	13.68	neutral	0.22	0.45	0.33	neutral	0.59	disease	0.41	neutral	0.46	neutral	1	0.57	neutral	0.72	deleterious	-6	neutral	0.48	deleterious	2.1	high_impact	0.13	medium_impact	-0.37	medium_impact	0.07	0.8	29.41	21.06	0.33	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11322	11322	A	G	MI.17509	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	563	188	N	S	aAc/aGc	-9.39	0	0	benign	0.01	neutral	0.9	neutral	4.61	neutral	-0.25	neutral	-0.34	neutral_impact	0.1	0.76	neutral	0.99	neutral	-1.21	0.01	neutral	0.79	0.8	0.31	neutral	0.19	neutral	0.29	neutral	0.35	neutral	3	0.08	neutral	0.95	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.74	medium_impact	-1.03	low_impact	0.09	0.8	29.41	21.06	0.35	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8510	8510	A	G	MI.1751	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	145	49	K	E	Aaa/Gaa	-20	0	0	probably_damaging	0.97	neutral	0.3	neutral	1.47	neutral	-0.91	neutral	-0.48	low_impact	1.28	0.93	neutral	0.59	neutral	2.40	18.82	deleterious	0.62949060	0.85	0.21	neutral	0.26	neutral	0.46	neutral	0.1	neutral	8	0.98	neutral	0.17	neutral	-2	neutral	0.69	deleterious	-2.19	low_impact	0.08	medium_impact	0	medium_impact	0.68	0.85	NA	NA	0.42	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11323	11323	C	G	MI.17510	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	564	188	N	K	aaC/aaG	-3.4	0	0	benign	0.11	neutral	0.95	neutral	4.55	neutral	-0.94	neutral	-1.16	neutral_impact	0.76	0.78	neutral	0.52	neutral	0.63	8.36	deleterious	0.77	0.8	0.44	neutral	0.49	neutral	0.48	neutral	0.51	disease	0	0.04	neutral	0.92	deleterious	-6	neutral	0.24	neutral	0.14	medium_impact	0.92	medium_impact	-0.37	medium_impact	0.35	0.8	29.41	21.06	0.19	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11323	11323	C	A	MI.17511	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	564	188	N	K	aaC/aaA	-3.4	0	0	benign	0.11	neutral	0.95	neutral	4.55	neutral	-0.94	neutral	-1.16	neutral_impact	0.76	0.78	neutral	0.52	neutral	1.03	10.85	neutral	0.77	0.8	0.44	neutral	0.49	neutral	0.48	neutral	0.51	disease	0	0.04	neutral	0.92	deleterious	-6	neutral	0.24	neutral	0.14	medium_impact	0.92	medium_impact	-0.37	medium_impact	0.35	0.8	29.41	21.06	0.19	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11324	11324	T	A	MI.17512	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	565	189	S	T	Tcc/Acc	-3.17	0	0	benign	0.01	neutral	0.37	neutral	4.55	neutral	-0.92	neutral	-0.29	neutral_impact	0.55	0.81	neutral	1	neutral	2.11	16.90	deleterious	0.49	0.55	0.51	disease	0.26	neutral	0.23	neutral	0.38	neutral	2	0.62	neutral	0.68	deleterious	-6	neutral	0.68	deleterious	1.16	medium_impact	0.07	medium_impact	-0.58	medium_impact	0.39	0.8	22.88	16.69	0.4	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11324	11324	T	C	MI.17513	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	565	189	S	P	Tcc/Ccc	-3.17	0	0	benign	0.04	neutral	0.13	neutral	4.47	deleterious	-3.05	neutral	-2.42	low_impact	1.02	0.75	neutral	0.73	neutral	3.94	23.50	deleterious	0.17	0.45	0.83	disease	0.82	disease	0.29	neutral	0.62	disease	2	0.86	neutral	0.55	deleterious	-6	neutral	0.83	deleterious	0.58	medium_impact	-0.26	medium_impact	-0.12	medium_impact	0.12	0.8	22.88	16.69	0.34	N	0.75	polymorphism	1	0.05	.	.	.	.	.	MNGIE fibroblasts	COSM6716747	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11324	11324	T	G	MI.17514	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	565	189	S	A	Tcc/Gcc	-3.17	0	0	benign	0.36	neutral	0.26	neutral	4.53	neutral	-1.24	neutral	-1.5	low_impact	1.07	0.7	neutral	0.77	neutral	3.64	23.20	deleterious	0.51	0.6	0.39	neutral	0.47	neutral	0.47	neutral	0.49	neutral	0	0.69	neutral	0.45	neutral	-6	neutral	0.68	deleterious	-0.48	medium_impact	-0.05	medium_impact	-0.07	medium_impact	0.18	0.8	22.88	16.69	0.4	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11325	11325	C	T	MI.17515	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	566	189	S	F	tCc/tTc	-3.42	0	0	possibly_damaging	0.9	neutral	0.15	neutral	4.49	neutral	-2.13	deleterious	-3.02	low_impact	0.97	0.7	neutral	0.58	neutral	4.24	23.90	deleterious	0.2	0.45	0.64	disease	0.79	disease	0.54	disease	0.58	disease	2	0.95	neutral	0.13	neutral	-3	neutral	0.79	deleterious	-1.61	low_impact	-0.22	medium_impact	-0.17	medium_impact	0.09	0.8	22.88	16.69	0.29	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11325	11325	C	G	MI.17516	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	566	189	S	C	tCc/tGc	-3.42	0	0	probably_damaging	0.95	deleterious	0.04	neutral	4.46	deleterious	-4.56	deleterious	-2.59	medium_impact	2.31	0.67	neutral	0.47	neutral	3.56	23.10	deleterious	0.15	0.4	0.83	disease	0.78	disease	0.51	disease	0.72	disease	4	0.99	deleterious	0.05	neutral	5	deleterious	0.79	deleterious	-1.92	low_impact	-0.57	medium_impact	1.16	medium_impact	0.12	0.8	22.88	16.69	0.31	N	0.60	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11325	11325	C	A	MI.17517	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	566	189	S	Y	tCc/tAc	-3.42	0	0	probably_damaging	0.93	neutral	0.2	neutral	4.52	neutral	-1.45	deleterious	-2.98	low_impact	1.54	0.81	neutral	0.58	neutral	4.07	23.70	deleterious	0.16	0.45	0.74	disease	0.79	disease	0.54	disease	0.68	disease	4	0.96	neutral	0.14	neutral	-2	neutral	0.80	deleterious	-1.77	low_impact	-0.14	medium_impact	0.4	medium_impact	0.15	0.8	22.88	16.69	0.28	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11327	11327	T	G	MI.17518	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	568	190	W	G	Tga/Gga	-8.49	0	0	probably_damaging	1	neutral	0.08	neutral	4.64	neutral	-0.03	deleterious	-8.55	low_impact	0.85	0.74	neutral	0.48	neutral	3.89	23.50	deleterious	0.1	0.4	0.58	disease	0.77	disease	0.71	disease	0.74	disease	5	1	deleterious	0.04	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	-0.39	medium_impact	-0.29	medium_impact	0.23	0.8	17.86	20.91	0.35	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11327	11327	T	C	MI.17519	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	568	190	W	R	Tga/Cga	-8.49	0	0	probably_damaging	1	neutral	0.07	neutral	4.63	neutral	-0.31	deleterious	-9.01	low_impact	1.5	0.72	neutral	0.28	neutral	3.52	23.10	deleterious	0.11	0.4	0.57	disease	0.87	disease	0.73	disease	0.8	disease	6	1	deleterious	0.04	neutral	-2	neutral	0.81	deleterious	-3.54	low_impact	-0.43	medium_impact	0.36	medium_impact	0.13	0.8	17.86	20.91	0.31	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8510	8510	A	C	MI.1752	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	145	49	K	Q	Aaa/Caa	-20	0	0	probably_damaging	0.99	neutral	0.31	neutral	1.41	neutral	-1.81	neutral	-0.51	neutral_impact	0.73	1	neutral	0.76	neutral	1.96	15.99	deleterious	0.62949060	0.85	0.27	neutral	0.21	neutral	0.32	neutral	0.11	neutral	8	0.99	deleterious	0.16	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	0.1	medium_impact	-0.47	medium_impact	0.72	0.85	NA	NA	0.48	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11328	11328	G	T	MI.17520	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	569	190	W	L	tGa/tTa	1.87	0.02	0	probably_damaging	1	neutral	0.24	neutral	4.74	neutral	1.56	deleterious	-8.19	neutral_impact	0.28	0.79	neutral	0.68	neutral	4.23	23.90	deleterious	0.13	0.4	0.37	neutral	0.77	disease	0.63	disease	0.56	disease	1	1	deleterious	0.12	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	-0.08	medium_impact	-0.85	medium_impact	0.20	0.8	17.86	20.91	0.33	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11328	11328	G	C	MI.17521	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	569	190	W	S	tGa/tCa	1.87	0.02	0	probably_damaging	1	neutral	0.18	neutral	4.71	neutral	1.15	deleterious	-8.9	neutral_impact	-0.11	0.81	neutral	0.63	neutral	3.92	23.50	deleterious	0.11	0.4	0.24	neutral	0.8	disease	0.6	disease	0.55	disease	1	1	deleterious	0.09	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	-0.17	medium_impact	-1.24	low_impact	0.17	0.8	17.86	20.91	0.34	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11329	11329	A	C	MI.17522	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	570	190	W	C	tgA/tgC	0.26	0	0.01	probably_damaging	1	deleterious	0.04	neutral	4.6	neutral	-1.87	deleterious	-8.42	medium_impact	2.05	0.74	neutral	0.34	neutral	3.99	23.60	deleterious	0.12	0.4	0.63	disease	0.88	disease	0.59	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.57	medium_impact	0.9	medium_impact	0.18	0.8	17.86	20.91	0.35	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11329	11329	A	T	MI.17523	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	570	190	W	C	tgA/tgT	0.26	0	0.01	probably_damaging	1	deleterious	0.04	neutral	4.6	neutral	-1.87	deleterious	-8.42	medium_impact	2.05	0.74	neutral	0.34	neutral	4.09	23.70	deleterious	0.12	0.4	0.63	disease	0.88	disease	0.59	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.57	medium_impact	0.9	medium_impact	0.18	0.8	17.86	20.91	0.35	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11330	11330	G	T	MI.17524	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	571	191	A	S	Gcc/Tcc	0.49	0	0	benign	0.02	neutral	0.63	neutral	4.6	neutral	-2.17	neutral	1.35	neutral_impact	-1.08	0.77	neutral	0.91	neutral	-0.95	0.02	neutral	0.28	0.45	0.35	neutral	0.14	neutral	0.14	neutral	0.24	neutral	5	0.34	neutral	0.81	deleterious	-6	neutral	0.14	neutral	0.87	medium_impact	0.33	medium_impact	-2.19	low_impact	0.42	0.8	20.7	16.32	0.36	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11330	11330	G	C	MI.17525	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	571	191	A	P	Gcc/Ccc	0.49	0	0	possibly_damaging	0.65	neutral	0.25	neutral	4.55	deleterious	-3.05	neutral	-1.62	neutral_impact	0.35	0.76	neutral	0.67	neutral	2.12	16.97	deleterious	0.07	0.35	0.65	disease	0.8	disease	0.41	neutral	0.59	disease	2	0.78	neutral	0.3	neutral	-3	neutral	0.56	deleterious	-0.97	medium_impact	-0.07	medium_impact	-0.78	medium_impact	0.51	0.8	20.7	16.32	0.31	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11330	11330	G	A	MI.17526	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	571	191	A	T	Gcc/Acc	0.49	0	0	benign	0.03	neutral	0.58	neutral	4.61	neutral	-1.99	neutral	0.05	neutral_impact	-0.46	0.75	neutral	0.95	neutral	0.91	10.11	neutral	0.25	0.45	0.3	neutral	0.21	neutral	0.14	neutral	0.37	neutral	3	0.38	neutral	0.78	deleterious	-6	neutral	0.21	neutral	0.7	medium_impact	0.28	medium_impact	-1.58	low_impact	0.76	0.85	20.7	16.32	0.43	N	0.27	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11331	11331	C	T	MI.17527	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	572	191	A	V	gCc/gTc	-0.2	0	0	benign	0.25	neutral	0.59	neutral	4.58	neutral	-1.1	neutral	-2.06	neutral_impact	0.11	0.8	neutral	0.69	neutral	2.59	20.10	deleterious	0.21	0.45	0.22	neutral	0.43	neutral	0.39	neutral	0.47	neutral	1	0.3	neutral	0.67	deleterious	-6	neutral	0.30	neutral	-0.27	medium_impact	0.29	medium_impact	-1.02	low_impact	0.78	0.85	20.7	16.32	0.24	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11331	11331	C	A	MI.17528	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	572	191	A	D	gCc/gAc	-0.2	0	0	benign	0.36	neutral	0.32	neutral	4.56	deleterious	-3.13	neutral	-1.12	neutral_impact	0.47	0.76	neutral	0.44	neutral	2.80	21.40	deleterious	0.04	0.35	0.68	disease	0.76	disease	0.56	disease	0.75	disease	5	0.62	neutral	0.48	deleterious	-6	neutral	0.44	deleterious	-0.48	medium_impact	0.02	medium_impact	-0.66	medium_impact	0.23	0.8	20.7	16.32	0.29	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11331	11331	C	G	MI.17529	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	572	191	A	G	gCc/gGc	-0.2	0	0	benign	0.25	neutral	0.47	neutral	4.62	neutral	-2.72	neutral	-0.35	neutral_impact	0.16	0.78	neutral	0.72	neutral	0.44	6.92	deleterious	0.3	0.45	0.51	disease	0.29	neutral	0.36	neutral	0.27	neutral	5	0.43	neutral	0.61	deleterious	-6	neutral	0.24	neutral	-0.27	medium_impact	0.17	medium_impact	-0.97	medium_impact	0.56	0.8	20.7	16.32	0.33	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8511	8511	A	T	MI.1753	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	146	49	K	M	aAa/aTa	0.59	0	0	probably_damaging	1	neutral	0.23	neutral	1.34	deleterious	-4.91	neutral	-1.34	neutral_impact	0.48	0.98	neutral	0.89	neutral	2.93	22.00	deleterious	0.57262910	0.85	0.56	disease	0.11	neutral	0.47	neutral	0.05	neutral	9	1	deleterious	0.12	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	-0.01	medium_impact	-0.69	medium_impact	0.59	0.85	NA	NA	0.6	P	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11333	11333	A	G	MI.17530	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	574	192	N	D	Aac/Gac	-13.55	0	0	benign	0.03	neutral	0.71	neutral	4.6	neutral	-1.44	neutral	-1.68	low_impact	1.51	0.71	neutral	0.75	neutral	1.76	14.78	neutral	0.49	0.55	0.43	neutral	0.3	neutral	0.34	neutral	0.45	neutral	1	0.24	neutral	0.84	deleterious	-6	neutral	0.70	deleterious	0.7	medium_impact	0.42	medium_impact	0.37	medium_impact	0.30	0.8	22.88	24.94	0.36	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11333	11333	A	T	MI.17531	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	574	192	N	Y	Aac/Tac	-13.55	0	0	possibly_damaging	0.61	neutral	0.3	neutral	4.61	neutral	-1.17	deleterious	-4	low_impact	1.3	0.81	neutral	0.56	neutral	3.70	23.30	deleterious	0.14	0.4	0.7	disease	0.74	disease	0.37	neutral	0.59	disease	2	0.72	neutral	0.35	neutral	-3	neutral	0.79	deleterious	-0.9	medium_impact	0	medium_impact	0.16	medium_impact	0.26	0.8	22.88	24.94	0.31	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11333	11333	A	C	MI.17532	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	574	192	N	H	Aac/Cac	-13.55	0	0	benign	0.01	neutral	0.28	neutral	4.6	neutral	-1.69	neutral	-1.86	low_impact	1.08	0.69	neutral	0.8	neutral	1.49	13.25	neutral	0.35	0.5	0.56	disease	0.52	disease	0.39	neutral	0.51	disease	0	0.71	neutral	0.64	deleterious	-6	neutral	0.72	deleterious	1.16	medium_impact	-0.03	medium_impact	-0.06	medium_impact	0.18	0.8	22.88	24.94	0.42	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11334	11334	A	C	MI.17533	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	575	192	N	T	aAc/aCc	-0.66	0	0	possibly_damaging	0.64	neutral	0.27	neutral	4.67	neutral	0.4	deleterious	-2.82	low_impact	1.89	0.77	neutral	0.96	neutral	2.30	18.16	deleterious	0.26	0.45	0.35	neutral	0.6	disease	0.28	neutral	0.48	neutral	1	0.76	neutral	0.32	neutral	-3	neutral	0.70	deleterious	-0.95	medium_impact	-0.04	medium_impact	0.74	medium_impact	0.28	0.8	22.88	24.94	0.41	N	0.32	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11334	11334	A	T	MI.17534	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	575	192	N	I	aAc/aTc	-0.66	0	0	possibly_damaging	0.87	neutral	0.17	neutral	4.78	neutral	1.64	deleterious	-4.86	low_impact	1.89	0.82	neutral	0.52	neutral	4.02	23.60	deleterious	0.17	0.45	0.4	neutral	0.84	disease	0.43	neutral	0.71	disease	4	0.93	neutral	0.15	neutral	-3	neutral	0.76	deleterious	-1.49	low_impact	-0.18	medium_impact	0.74	medium_impact	0.18	0.8	22.88	24.94	0.35	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11334	11334	A	G	MI.17535	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	575	192	N	S	aAc/aGc	-0.66	0	0	benign	0.36	neutral	0.62	neutral	4.67	neutral	0.44	neutral	-1.95	neutral_impact	0.21	0.72	neutral	0.97	neutral	1.64	14.08	neutral	0.52	0.6	0.2	neutral	0.36	neutral	0.27	neutral	0.45	neutral	1	0.32	neutral	0.63	deleterious	-6	neutral	0.66	deleterious	-0.48	medium_impact	0.32	medium_impact	-0.92	medium_impact	0.18	0.8	22.88	24.94	0.37	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11335	11335	C	G	MI.17536	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	576	192	N	K	aaC/aaG	0.03	0	0	possibly_damaging	0.56	neutral	0.08	neutral	4.62	neutral	-0.47	deleterious	-2.96	low_impact	1.38	0.79	neutral	0.37	neutral	3.90	23.50	deleterious	0.43	0.55	0.35	neutral	0.73	disease	0.56	disease	0.71	disease	4	0.92	neutral	0.26	neutral	-3	neutral	0.73	deleterious	-0.82	medium_impact	-0.39	medium_impact	0.24	medium_impact	0.31	0.8	22.88	24.94	0.31	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11335	11335	C	A	MI.17537	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	576	192	N	K	aaC/aaA	0.03	0	0	possibly_damaging	0.56	neutral	0.08	neutral	4.62	neutral	-0.47	deleterious	-2.96	low_impact	1.38	0.79	neutral	0.37	neutral	4.38	24.10	deleterious	0.43	0.55	0.35	neutral	0.73	disease	0.56	disease	0.71	disease	4	0.92	neutral	0.26	neutral	-3	neutral	0.73	deleterious	-0.82	medium_impact	-0.39	medium_impact	0.24	medium_impact	0.31	0.8	22.88	24.94	0.31	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11336	11336	A	T	MI.17538	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	577	193	N	Y	Aac/Tac	-4.58	0	0	benign	0.03	neutral	1	neutral	4.57	neutral	-1.86	neutral	-2.28	low_impact	0.87	0.77	neutral	0.71	neutral	2.18	17.41	deleterious	0.14	0.4	0.48	neutral	0.56	disease	0.42	neutral	0.47	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.61	deleterious	0.7	medium_impact	1.88	high_impact	-0.27	medium_impact	0.27	0.8	21.35	22.84	0.19	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11336	11336	A	C	MI.17539	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	577	193	N	H	Aac/Cac	-4.58	0	0	possibly_damaging	0.75	neutral	0.54	neutral	4.56	neutral	-2.37	neutral	-1.17	low_impact	1.3	0.85	neutral	0.89	neutral	1.62	13.97	neutral	0.35	0.5	0.23	neutral	0.41	neutral	0.39	neutral	0.44	neutral	1	0.72	neutral	0.4	neutral	-3	neutral	0.55	deleterious	-1.17	low_impact	0.24	medium_impact	0.16	medium_impact	0.19	0.8	21.35	22.84	0.29	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8511	8511	A	C	MI.1754	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	146	49	K	T	aAa/aCa	0.59	0	0	probably_damaging	0.98	neutral	0.44	neutral	1.42	neutral	-1.62	neutral	1.28	neutral_impact	-1.47	0.99	neutral	0.97	neutral	0.95	10.39	neutral	0.49162191	0.85	0.15	neutral	0.23	neutral	0.33	neutral	0.14	neutral	7	0.98	deleterious	0.23	neutral	-2	neutral	0.66	deleterious	-2.36	low_impact	0.23	medium_impact	-2.36	low_impact	0.71	0.85	NA	NA	0.43	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11336	11336	A	G	MI.17540	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	577	193	N	D	Aac/Gac	-4.58	0	0	benign	0.02	neutral	0.21	neutral	4.56	neutral	-2.12	neutral	-0.93	low_impact	1.45	0.8	neutral	0.86	neutral	0.66	8.60	deleterious	0.52	0.6	0.42	neutral	0.45	neutral	0.51	disease	0.48	neutral	1	0.78	neutral	0.6	deleterious	-6	neutral	0.30	neutral	0.87	medium_impact	-0.12	medium_impact	0.31	medium_impact	0.32	0.8	21.35	22.84	0.4	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11337	11337	A	G	MI.17541	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	578	193	N	S	aAc/aGc	-2.5	0	0	benign	0.03	neutral	0.42	neutral	4.66	neutral	0.17	neutral	-0.57	neutral_impact	0.11	0.78	neutral	0.99	neutral	-0.47	0.27	neutral	0.47	0.55	0.24	neutral	0.26	neutral	0.26	neutral	0.43	neutral	1	0.56	neutral	0.7	deleterious	-6	neutral	0.10	neutral	0.7	medium_impact	0.12	medium_impact	-1.02	low_impact	0.27	0.8	21.35	22.84	0.39	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11337	11337	A	T	MI.17542	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	578	193	N	I	aAc/aTc	-2.5	0	0	possibly_damaging	0.68	neutral	0.42	neutral	4.64	neutral	-0.07	deleterious	-2.56	neutral_impact	-0.09	0.81	neutral	0.99	neutral	2.45	19.15	deleterious	0.16	0.45	0.32	neutral	0.64	disease	0.28	neutral	0.44	neutral	1	0.69	neutral	0.37	neutral	-3	neutral	0.54	deleterious	-1.03	low_impact	0.12	medium_impact	-1.22	low_impact	0.19	0.8	21.35	22.84	0.28	N	0.12	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11337	11337	A	C	MI.17543	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	578	193	N	T	aAc/aCc	-2.5	0	0	benign	0.25	neutral	0.4	neutral	4.69	neutral	0.59	neutral	-1.24	low_impact	0.96	0.76	neutral	0.99	neutral	0.27	5.37	deleterious	0.27	0.45	0.31	neutral	0.32	neutral	0.23	neutral	0.45	neutral	1	0.52	neutral	0.58	deleterious	-6	neutral	0.21	neutral	-0.27	medium_impact	0.1	medium_impact	-0.18	medium_impact	0.26	0.8	21.35	22.84	0.4	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11338	11338	C	A	MI.17544	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	579	193	N	K	aaC/aaA	-2.04	0	0	benign	0.36	neutral	0.36	neutral	4.59	neutral	-1.16	neutral	-0.4	neutral_impact	0.1	0.73	neutral	0.75	neutral	-0.13	1.49	neutral	0.37	0.5	0.27	neutral	0.16	neutral	0.33	neutral	0.23	neutral	5	0.57	neutral	0.5	deleterious	-6	neutral	0.27	neutral	-0.48	medium_impact	0.06	medium_impact	-1.03	low_impact	0.37	0.8	21.35	22.84	0.43	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11338	11338	C	G	MI.17545	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	579	193	N	K	aaC/aaG	-2.04	0	0	benign	0.36	neutral	0.36	neutral	4.59	neutral	-1.16	neutral	-0.4	neutral_impact	0.1	0.73	neutral	0.75	neutral	-0.57	0.15	neutral	0.37	0.5	0.27	neutral	0.16	neutral	0.33	neutral	0.23	neutral	5	0.57	neutral	0.5	deleterious	-6	neutral	0.27	neutral	-0.48	medium_impact	0.06	medium_impact	-1.03	low_impact	0.37	0.8	21.35	22.84	0.43	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11339	11339	T	G	MI.17546	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	580	194	L	V	Tta/Gta	-11.02	0	0.01	benign	0.26	neutral	0.16	neutral	4.45	neutral	-1.52	neutral	-0.85	low_impact	1.68	0.76	neutral	0.83	neutral	1.43	12.95	neutral	0.29	0.45	0.37	neutral	0.5	disease	0.47	neutral	0.48	neutral	0	0.81	neutral	0.45	neutral	-6	neutral	0.25	neutral	-0.29	medium_impact	-0.2	medium_impact	0.54	medium_impact	0.64	0.8	27.67	21.8	0.44	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11339	11339	T	A	MI.17547	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	580	194	L	M	Tta/Ata	-11.02	0	0.01	probably_damaging	0.9	neutral	0.22	neutral	4.4	deleterious	-3.16	neutral	-0.66	low_impact	1.62	0.75	neutral	0.97	neutral	2.29	18.10	deleterious	0.28	0.45	0.41	neutral	0.31	neutral	0.27	neutral	0.47	neutral	1	0.94	neutral	0.16	neutral	-2	neutral	0.59	deleterious	-1.61	low_impact	-0.11	medium_impact	0.48	medium_impact	0.51	0.8	27.67	21.8	0.49	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11340	11340	T	G	MI.17548	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	581	194	L	W	tTa/tGa	-6.65	0	0	probably_damaging	0.98	neutral	0.13	neutral	4.34	deleterious	-4.03	deleterious	-3.28	low_impact	1.53	0.73	neutral	0.43	neutral	3.62	23.20	deleterious	0.04	0.35	0.22	neutral	0.79	disease	0.62	disease	0.75	disease	5	0.99	deleterious	0.08	neutral	-2	neutral	0.67	deleterious	-2.31	low_impact	-0.26	medium_impact	0.39	medium_impact	0.29	0.8	27.67	21.8	0.3	N	0.47	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11340	11340	T	C	MI.17549	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	581	194	L	S	tTa/tCa	-6.65	0	0	probably_damaging	0.95	deleterious	0.04	neutral	4.36	deleterious	-3.91	deleterious	-3.37	medium_impact	2.07	0.73	neutral	0.72	neutral	3.56	23.10	deleterious	0.02	0.35	0.51	disease	0.74	disease	0.59	disease	0.72	disease	4	0.99	deleterious	0.05	neutral	5	deleterious	0.70	deleterious	-1.92	low_impact	-0.57	medium_impact	0.92	medium_impact	0.27	0.8	27.67	21.8	0.33	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8512	8512	A	C	MI.1755	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	147	49	K	N	aaA/aaC	-2.88	0	0.03	probably_damaging	0.99	neutral	0.34	neutral	1.47	neutral	-0.92	neutral	1.74	neutral_impact	-0.68	1	neutral	0.95	neutral	2.23	17.70	deleterious	0.82750062	0.90	0.15	neutral	0.07	neutral	0.32	neutral	0.04	neutral	9	0.99	deleterious	0.18	neutral	-2	neutral	0.64	deleterious	-2.65	low_impact	0.13	medium_impact	-1.68	low_impact	0.80	0.85	NA	NA	0.47	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11341	11341	A	T	MI.17550	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	582	194	L	F	ttA/ttT	5.55	0.85	0	benign	0.11	neutral	0.45	neutral	4.5	neutral	-2.79	neutral	-1.2	neutral_impact	0.62	0.79	neutral	0.99	neutral	1.62	13.96	neutral	0.2	0.45	0.43	neutral	0.48	neutral	0.31	neutral	0.47	neutral	1	0.48	neutral	0.67	deleterious	-6	neutral	0.59	deleterious	0.14	medium_impact	0.15	medium_impact	-0.51	medium_impact	0.55	0.8	27.67	21.8	0.48	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11341	11341	A	C	MI.17551	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	582	194	L	F	ttA/ttC	5.55	0.85	0	benign	0.11	neutral	0.45	neutral	4.5	neutral	-2.79	neutral	-1.2	neutral_impact	0.62	0.79	neutral	0.99	neutral	1.48	13.19	neutral	0.2	0.45	0.43	neutral	0.48	neutral	0.31	neutral	0.47	neutral	1	0.48	neutral	0.67	deleterious	-6	neutral	0.59	deleterious	0.14	medium_impact	0.15	medium_impact	-0.51	medium_impact	0.55	0.8	27.67	21.8	0.48	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11342	11342	A	T	MI.17552	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	583	195	M	L	Ata/Tta	-9.87	0	0	benign	0	neutral	1	neutral	4.84	neutral	2.07	neutral	0.12	neutral_impact	-1.24	0.77	neutral	0.97	neutral	1.05	10.96	neutral	0.25	0.45	0.21	neutral	0.46	neutral	0.29	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.50	deleterious	2.1	high_impact	1.88	high_impact	-2.35	low_impact	0.27	0.8	20.04	21.95	0.32	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11342	11342	A	C	MI.17553	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	583	195	M	L	Ata/Cta	-9.87	0	0	benign	0	neutral	1	neutral	4.84	neutral	2.07	neutral	0.12	neutral_impact	-1.24	0.77	neutral	0.97	neutral	0.99	10.59	neutral	0.25	0.45	0.21	neutral	0.46	neutral	0.29	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.50	deleterious	2.1	high_impact	1.88	high_impact	-2.35	low_impact	0.27	0.8	20.04	21.95	0.32	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11342	11342	A	G	MI.17554	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	583	195	M	V	Ata/Gta	-9.87	0	0	benign	0	neutral	0.23	neutral	4.69	neutral	1.36	neutral	-1.34	neutral_impact	0.62	0.76	neutral	0.73	neutral	2.60	20.20	deleterious	0.24	0.45	0.45	neutral	0.7	disease	0.64	disease	0.74	disease	5	0.77	neutral	0.62	deleterious	-6	neutral	0.62	deleterious	2.1	high_impact	-0.09	medium_impact	-0.51	medium_impact	0.31	0.8	20.04	21.95	0.33	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11343	11343	T	A	MI.17555	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	584	195	M	K	aTa/aAa	-2.96	0	0	benign	0.23	neutral	0.07	neutral	4.59	neutral	-2.31	deleterious	-2.82	low_impact	1.84	0.64	neutral	0.45	neutral	4.06	23.70	deleterious	0.03	0.35	0.77	disease	0.87	disease	0.71	disease	0.82	disease	6	0.92	neutral	0.42	neutral	-6	neutral	0.81	deleterious	-0.23	medium_impact	-0.43	medium_impact	0.69	medium_impact	0.26	0.8	20.04	21.95	0.3	N	0.88	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11343	11343	T	C	MI.17556	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	584	195	M	T	aTa/aCa	-2.96	0	0	benign	0	neutral	0.07	neutral	4.62	neutral	-0.18	neutral	-2.11	low_impact	1.22	0.78	neutral	0.95	neutral	1.78	14.90	neutral	0.09	0.35	0.6	disease	0.74	disease	0.64	disease	0.63	disease	3	0.93	neutral	0.54	deleterious	-6	neutral	0.76	deleterious	2.1	high_impact	-0.43	medium_impact	0.08	medium_impact	0.15	0.8	20.04	21.95	0.31	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11344	11344	A	T	MI.17557	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	585	195	M	I	atA/atT	2.56	0.91	0	benign	0	neutral	0.27	neutral	4.73	neutral	1.34	neutral	-0.96	neutral_impact	0.62	0.74	neutral	0.68	neutral	3.34	22.90	deleterious	0.25	0.45	0.34	neutral	0.81	disease	0.42	neutral	0.56	disease	1	0.73	neutral	0.64	deleterious	-6	neutral	0.70	deleterious	2.1	high_impact	-0.04	medium_impact	-0.51	medium_impact	0.37	0.8	20.04	21.95	0.34	N	0.42	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11344	11344	A	C	MI.17558	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	585	195	M	I	atA/atC	2.56	0.91	0	benign	0	neutral	0.27	neutral	4.73	neutral	1.34	neutral	-0.96	neutral_impact	0.62	0.74	neutral	0.68	neutral	3.33	22.90	deleterious	0.25	0.45	0.34	neutral	0.81	disease	0.42	neutral	0.56	disease	1	0.73	neutral	0.64	deleterious	-6	neutral	0.70	deleterious	2.1	high_impact	-0.04	medium_impact	-0.51	medium_impact	0.37	0.8	20.04	21.95	0.34	N	0.42	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11345	11345	T	G	MI.17559	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	586	196	W	G	Tga/Gga	0.26	0.9	0	benign	0.08	neutral	0.16	neutral	4.65	neutral	0.06	deleterious	-10.01	medium_impact	2.48	0.74	neutral	0.58	neutral	3.82	23.40	deleterious	0.07	0.35	0.34	neutral	0.9	disease	0.77	disease	0.65	disease	3	0.82	neutral	0.54	deleterious	-3	neutral	0.77	deleterious	0.28	medium_impact	-0.2	medium_impact	1.33	medium_impact	0.21	0.8	46.19	9.46	0.43	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8512	8512	A	T	MI.1756	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	147	49	K	N	aaA/aaT	-2.88	0	0.03	probably_damaging	0.99	neutral	0.34	neutral	1.47	neutral	-0.92	neutral	1.74	neutral_impact	-0.68	1	neutral	0.95	neutral	2.32	18.28	deleterious	0.82750062	0.90	0.15	neutral	0.07	neutral	0.32	neutral	0.04	neutral	9	0.99	deleterious	0.18	neutral	-2	neutral	0.64	deleterious	-2.65	low_impact	0.13	medium_impact	-1.68	low_impact	0.80	0.85	NA	NA	0.47	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11345	11345	T	C	MI.17560	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	586	196	W	R	Tga/Cga	0.26	0.9	0	probably_damaging	0.97	deleterious	0.02	neutral	4.6	neutral	-2.63	deleterious	-10.79	high_impact	3.92	0.69	neutral	0.36	neutral	3.51	23.10	deleterious	0.04	0.35	0.57	disease	0.95	disease	0.82	disease	0.92	disease	8	1	deleterious	0.03	neutral	6	deleterious	0.86	deleterious	-2.14	low_impact	-0.75	medium_impact	2.75	high_impact	0.24	0.8	46.19	9.46	0.49	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11346	11346	G	C	MI.17561	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	587	196	W	S	tGa/tCa	3.02	1	0	possibly_damaging	0.89	neutral	0.07	neutral	4.75	neutral	-1.12	deleterious	-10.79	medium_impact	2.6	0.75	neutral	0.57	neutral	3.94	23.50	deleterious	0.07	0.35	0.38	neutral	0.92	disease	0.75	disease	0.62	disease	2	0.97	neutral	0.09	neutral	0	NA	0.80	deleterious	-1.57	low_impact	-0.43	medium_impact	1.45	medium_impact	0.20	0.8	46.19	9.46	0.52	N	0.93	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11346	11346	G	T	MI.17562	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	587	196	W	L	tGa/tTa	3.02	1	0	probably_damaging	0.93	neutral	0.24	neutral	4.74	neutral	1.04	deleterious	-10.02	medium_impact	2.04	0.78	neutral	0.47	neutral	4.18	23.80	deleterious	0.09	0.4	0.27	neutral	0.91	disease	0.75	disease	0.77	disease	5	0.95	neutral	0.16	neutral	1	deleterious	0.74	deleterious	-1.77	low_impact	-0.08	medium_impact	0.89	medium_impact	0.13	0.8	46.19	9.46	0.45	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11347	11347	A	T	MI.17563	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	588	196	W	C	tgA/tgT	4.17	1	0	probably_damaging	0.98	deleterious	0.02	neutral	4.59	neutral	-0.8	deleterious	-10.02	medium_impact	2.88	0.74	neutral	0.39	neutral	4.07	23.70	deleterious	0.07	0.35	0.63	disease	0.95	disease	0.76	disease	0.9	disease	8	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-2.31	low_impact	-0.75	medium_impact	1.72	medium_impact	0.17	0.8	46.19	9.46	0.51	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11347	11347	A	C	MI.17564	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	588	196	W	C	tgA/tgC	4.17	1	0	probably_damaging	0.98	deleterious	0.02	neutral	4.59	neutral	-0.8	deleterious	-10.02	medium_impact	2.88	0.74	neutral	0.39	neutral	3.93	23.50	deleterious	0.07	0.35	0.63	disease	0.95	disease	0.76	disease	0.9	disease	8	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-2.31	low_impact	-0.75	medium_impact	1.72	medium_impact	0.17	0.8	46.19	9.46	0.5	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11348	11348	C	G	MI.17565	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	589	197	L	V	Cta/Gta	0.03	0	0	possibly_damaging	0.9	neutral	0.3	neutral	4.39	neutral	-1.92	neutral	-1.35	medium_impact	2.19	0.73	neutral	0.4	neutral	2.01	16.24	deleterious	0.3	0.45	0.34	neutral	0.55	disease	0.34	neutral	0.47	neutral	1	0.91	neutral	0.2	neutral	0	NA	0.70	deleterious	-1.61	low_impact	0	medium_impact	1.04	medium_impact	0.62	0.8	20.26	19.44	0.39	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11348	11348	C	A	MI.17566	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	589	197	L	M	Cta/Ata	0.03	0	0	possibly_damaging	0.76	neutral	0.1	neutral	4.3	deleterious	-3.69	neutral	-0.99	medium_impact	2.29	0.75	neutral	0.33	neutral	2.47	19.26	deleterious	0.24	0.45	0.19	neutral	0.54	disease	0.37	neutral	0.45	neutral	1	0.93	neutral	0.17	neutral	0	NA	0.68	deleterious	-1.19	low_impact	-0.33	medium_impact	1.14	medium_impact	0.48	0.8	20.26	19.44	0.44	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11349	11349	T	G	MI.17567	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	590	197	L	R	cTa/cGa	-2.73	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.27	deleterious	-4.93	deleterious	-3.29	high_impact	4.05	0.68	neutral	0.09	damaging	4.17	23.80	deleterious	0.02	0.35	0.71	disease	0.94	disease	0.71	disease	0.85	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-2.31	low_impact	-0.92	medium_impact	2.88	high_impact	0.23	0.8	20.26	19.44	0.29	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11349	11349	T	A	MI.17568	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	590	197	L	Q	cTa/cAa	-2.73	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.27	deleterious	-5.62	deleterious	-3.24	high_impact	4.05	0.69	neutral	0.1	damaging	4.31	24.00	deleterious	0.03	0.35	0.73	disease	0.85	disease	0.58	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.59	low_impact	-0.92	medium_impact	2.88	high_impact	0.42	0.8	20.26	19.44	0.33	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11349	11349	T	C	MI.17569	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	590	197	L	P	cTa/cCa	-2.73	0	0	probably_damaging	1	deleterious	0.01	neutral	4.26	deleterious	-5.77	deleterious	-3.84	medium_impact	3.36	0.63	neutral	0.08	damaging	3.87	23.50	deleterious	0.02	0.35	0.78	disease	0.93	disease	0.7	disease	0.81	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.89	deleterious	-3.54	low_impact	-0.92	medium_impact	2.2	high_impact	0.37	0.8	20.26	19.44	0.25	N	0.94	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8513	8513	C	A	MI.1757	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	148	50	P	T	Ccc/Acc	-4.27	0	0	probably_damaging	1	neutral	0.41	neutral	1.68	deleterious	-7.01	deleterious	-5.77	neutral_impact	0.54	0.95	neutral	0.59	neutral	3.85	23.40	deleterious	0.50472207	0.85	0.62	disease	0.34	neutral	0.53	disease	0.23	neutral	5	1	deleterious	0.21	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.2	medium_impact	-0.64	medium_impact	0.65	0.85	1.47	8.21	0.39	N	0.73	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11351	11351	G	T	MI.17570	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	592	198	A	S	Gct/Tct	-2.27	0	0	possibly_damaging	0.74	neutral	0.56	neutral	4.61	neutral	-2.51	neutral	-1.62	low_impact	1.64	0.72	neutral	0.63	neutral	2.56	19.86	deleterious	0.21	0.45	0.37	neutral	0.75	disease	0.33	neutral	0.53	disease	1	0.71	neutral	0.41	neutral	-3	neutral	0.76	deleterious	-1.14	low_impact	0.26	medium_impact	0.5	medium_impact	0.42	0.8	18.95	16.41	0.32	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11351	11351	G	A	MI.17571	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	592	198	A	T	Gct/Act	-2.27	0	0	benign	0.26	neutral	0.39	neutral	4.59	neutral	-2.3	deleterious	-2.51	medium_impact	2.58	0.78	neutral	0.73	neutral	4.08	23.70	deleterious	0.14	0.4	0.42	neutral	0.86	disease	0.46	neutral	0.67	disease	3	0.53	neutral	0.57	deleterious	-3	neutral	0.80	deleterious	-0.29	medium_impact	0.09	medium_impact	1.43	medium_impact	0.59	0.8	18.95	16.41	0.32	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11351	11351	G	C	MI.17572	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	592	198	A	P	Gct/Cct	-2.27	0	0	probably_damaging	0.97	neutral	0.2	neutral	4.55	deleterious	-4.38	deleterious	-3.27	medium_impact	2.92	0.66	neutral	0.32	neutral	3.74	23.30	deleterious	0.03	0.35	0.65	disease	0.95	disease	0.67	disease	0.82	disease	6	0.98	neutral	0.12	neutral	1	deleterious	0.88	deleterious	-2.14	low_impact	-0.14	medium_impact	1.76	medium_impact	0.49	0.8	18.95	16.41	0.29	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11352	11352	C	T	MI.17573	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	593	198	A	V	gCt/gTt	3.02	0.99	0	possibly_damaging	0.83	neutral	0.57	neutral	4.68	neutral	-1.04	deleterious	-2.84	medium_impact	2.18	0.76	neutral	0.49	neutral	4.35	24.10	deleterious	0.14	0.4	0.41	neutral	0.87	disease	0.54	disease	0.68	disease	4	0.81	neutral	0.37	neutral	0	NA	0.78	deleterious	-1.37	low_impact	0.27	medium_impact	1.03	medium_impact	0.64	0.8	18.95	16.41	0.44	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11352	11352	C	A	MI.17574	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	593	198	A	D	gCt/gAt	3.02	0.99	0	probably_damaging	0.94	neutral	0.2	neutral	4.54	deleterious	-5.38	deleterious	-3.69	high_impact	3.73	0.69	neutral	0.36	neutral	4.52	24.30	deleterious	0.03	0.35	0.44	neutral	0.95	disease	0.66	disease	0.83	disease	7	0.96	neutral	0.13	neutral	2	deleterious	0.82	deleterious	-1.84	low_impact	-0.14	medium_impact	2.56	high_impact	0.28	0.8	18.95	16.41	0.55	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11352	11352	C	G	MI.17575	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	593	198	A	G	gCt/gGt	3.02	0.99	0	benign	0.12	neutral	0.6	neutral	4.63	neutral	-1.15	neutral	-1.61	low_impact	1.23	0.7	neutral	0.62	neutral	2.24	17.77	deleterious	0.22	0.45	0.48	neutral	0.51	disease	0.3	neutral	0.45	neutral	1	0.3	neutral	0.74	deleterious	-6	neutral	0.75	deleterious	0.1	medium_impact	0.3	medium_impact	0.09	medium_impact	0.56	0.8	18.95	16.41	0.41	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11354	11354	T	A	MI.17576	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	595	199	Y	N	Tac/Aac	-5.96	0	0	possibly_damaging	0.8	deleterious	0.03	neutral	4.63	neutral	-0.82	neutral	-1.04	neutral_impact	0.14	0.71	neutral	0.64	neutral	3.78	23.40	deleterious	0.09	0.35	0.38	neutral	0.85	disease	0.48	neutral	0.76	disease	5	0.98	deleterious	0.12	neutral	1	deleterious	0.70	deleterious	-1.28	low_impact	-0.64	medium_impact	-0.99	medium_impact	0.18	0.8	14.81	11.39	0.35	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11354	11354	T	C	MI.17577	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	595	199	Y	H	Tac/Cac	-5.96	0	0	possibly_damaging	0.84	neutral	0.05	neutral	4.63	neutral	-1.06	neutral	-0.92	neutral_impact	0.7	0.75	neutral	0.53	neutral	3.39	23.00	deleterious	0.18	0.45	0.4	neutral	0.69	disease	0.58	disease	0.68	disease	4	0.97	neutral	0.11	neutral	-3	neutral	0.67	deleterious	-1.39	low_impact	-0.52	medium_impact	-0.43	medium_impact	0.21	0.8	14.81	11.39	0.38	N	0.67	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11354	11354	T	G	MI.17578	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	595	199	Y	D	Tac/Gac	-5.96	0	0	possibly_damaging	0.71	deleterious	0.02	neutral	4.63	neutral	-1.67	neutral	-1.07	neutral_impact	0.7	0.68	neutral	0.47	neutral	3.74	23.30	deleterious	0.06	0.35	0.63	disease	0.88	disease	0.59	disease	0.8	disease	6	0.98	deleterious	0.16	neutral	1	deleterious	0.74	deleterious	-1.08	low_impact	-0.75	medium_impact	-0.43	medium_impact	0.16	0.8	14.81	11.39	0.32	N	0.85	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11355	11355	A	T	MI.17579	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	596	199	Y	F	tAc/tTc	1.87	0.95	0	possibly_damaging	0.49	neutral	0.27	neutral	4.77	neutral	2.82	neutral	-0.04	neutral_impact	-1.66	0.79	neutral	0.86	neutral	1.61	13.91	neutral	0.24	0.45	0.33	neutral	0.74	disease	0.42	neutral	0.55	disease	1	0.7	neutral	0.39	neutral	-3	neutral	0.53	deleterious	-0.7	medium_impact	-0.04	medium_impact	-2.77	low_impact	0.32	0.8	14.81	11.39	0.36	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8513	8513	C	T	MI.1758	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	148	50	P	S	Ccc/Tcc	-4.27	0	0	probably_damaging	1	neutral	0.42	neutral	1.72	deleterious	-6.57	deleterious	-6.04	low_impact	1.7	0.99	neutral	0.62	neutral	2.77	21.20	deleterious	0.51005936	0.85	0.55	disease	0.18	neutral	0.6	disease	0.13	neutral	7	0.99	deleterious	0.21	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.21	medium_impact	0.36	medium_impact	0.21	0.85	1.47	8.21	0.47	N	0.70	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11355	11355	A	C	MI.17580	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	596	199	Y	S	tAc/tCc	1.87	0.95	0	benign	0.34	neutral	0.1	neutral	4.67	neutral	1.12	neutral	0.43	neutral_impact	-0.85	0.77	neutral	0.78	neutral	1.92	15.73	deleterious	0.08	0.35	0.21	neutral	0.73	disease	0.36	neutral	0.54	disease	1	0.88	neutral	0.38	neutral	-6	neutral	0.43	neutral	-0.45	medium_impact	-0.33	medium_impact	-1.97	low_impact	0.23	0.8	14.81	11.39	0.37	N	0.78	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11355	11355	A	G	MI.17581	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	596	199	Y	C	tAc/tGc	1.87	0.95	0	benign	0.01	neutral	0.9	neutral	4.63	neutral	-0.76	neutral	7.71	neutral_impact	-2.82	0.73	neutral	0.93	neutral	-1.18	0.01	neutral	0.08	0.35	0.2	neutral	0.34	neutral	0.22	neutral	0.42	neutral	2	0.08	neutral	0.95	deleterious	-6	neutral	0.14	neutral	1.16	medium_impact	0.74	medium_impact	-3.92	low_impact	0.09	0.8	14.81	11.39	0.32	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11357	11357	A	T	MI.17582	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	598	200	T	S	Aca/Tca	-2.73	0	0	benign	0.3	neutral	0.23	neutral	4.59	neutral	-1.08	neutral	-0.64	neutral_impact	0.76	0.75	neutral	0.7	neutral	1.32	12.36	neutral	0.31	0.45	0.27	neutral	0.47	neutral	0.49	neutral	0.5	neutral	0	0.72	neutral	0.47	neutral	-6	neutral	0.21	neutral	-0.37	medium_impact	-0.09	medium_impact	-0.37	medium_impact	0.30	0.8	14.6	12.64	0.41	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11357	11357	A	G	MI.17583	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	598	200	T	A	Aca/Gca	-2.73	0	0	benign	0.12	deleterious	0.01	neutral	4.6	neutral	0.37	neutral	-0.33	low_impact	1.07	0.75	neutral	0.8	neutral	1.41	12.86	neutral	0.18	0.45	0.26	neutral	0.46	neutral	0.49	neutral	0.48	neutral	0	0.99	deleterious	0.45	neutral	-2	neutral	0.14	neutral	0.1	medium_impact	-0.92	medium_impact	-0.07	medium_impact	0.28	0.8	14.6	12.64	0.42	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11357	11357	A	C	MI.17584	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	598	200	T	P	Aca/Cca	-2.73	0	0	possibly_damaging	0.71	deleterious	0	neutral	4.53	deleterious	-3.01	neutral	-1.47	medium_impact	2.11	0.67	neutral	0.49	neutral	1.73	14.60	neutral	0.05	0.35	0.51	disease	0.85	disease	0.65	disease	0.82	disease	6	1	deleterious	0.15	neutral	4	deleterious	0.55	deleterious	-1.08	low_impact	-1.48	low_impact	0.96	medium_impact	0.20	0.8	14.6	12.64	0.32	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11358	11358	C	T	MI.17585	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	599	200	T	M	aCa/aTa	0.26	0	0	benign	0.02	neutral	0.44	neutral	4.58	neutral	-0.55	neutral	2.57	neutral_impact	-1.07	0.73	neutral	0.96	neutral	-0.20	1.08	neutral	0.1	0.4	0.32	neutral	0.3	neutral	0.28	neutral	0.46	neutral	1	0.54	neutral	0.71	deleterious	-6	neutral	0.12	neutral	0.87	medium_impact	0.14	medium_impact	-2.18	low_impact	0.38	0.8	14.6	12.64	0.36	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11358	11358	C	A	MI.17586	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	599	200	T	K	aCa/aAa	0.26	0	0	benign	0.34	deleterious	0	neutral	4.54	neutral	-2.59	neutral	-0.92	medium_impact	2.11	0.71	neutral	0.58	neutral	2.55	19.76	deleterious	0.07	0.35	0.23	neutral	0.8	disease	0.64	disease	0.77	disease	5	1	deleterious	0.33	neutral	1	deleterious	0.30	neutral	-0.45	medium_impact	-1.48	low_impact	0.96	medium_impact	0.34	0.8	14.6	12.64	0.38	N	0.65	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11360	11360	A	C	MI.17587	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	601	201	M	L	Ata/Cta	-2.96	0	0	benign	0.03	neutral	1	neutral	4.82	neutral	1.81	neutral	-1.08	neutral_impact	0.56	0.68	neutral	0.91	neutral	1.17	11.61	neutral	0.23	0.45	0.28	neutral	0.52	disease	0.38	neutral	0.46	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.51	deleterious	0.7	medium_impact	1.88	high_impact	-0.57	medium_impact	0.17	0.8	18.74	16.33	0.37	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11360	11360	A	T	MI.17588	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	601	201	M	L	Ata/Tta	-2.96	0	0	benign	0.03	neutral	1	neutral	4.82	neutral	1.81	neutral	-1.08	neutral_impact	0.56	0.68	neutral	0.91	neutral	1.36	12.57	neutral	0.23	0.45	0.28	neutral	0.52	disease	0.38	neutral	0.46	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.51	deleterious	0.7	medium_impact	1.88	high_impact	-0.57	medium_impact	0.17	0.8	18.74	16.33	0.38	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11360	11360	A	G	MI.17589	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	601	201	M	V	Ata/Gta	-2.96	0	0	possibly_damaging	0.54	neutral	0.17	neutral	4.84	neutral	1.35	neutral	-1.82	low_impact	1.65	0.76	neutral	0.68	neutral	1.46	13.13	neutral	0.23	0.45	0.31	neutral	0.74	disease	0.46	neutral	0.55	disease	1	0.82	neutral	0.32	neutral	-3	neutral	0.60	deleterious	-0.78	medium_impact	-0.18	medium_impact	0.51	medium_impact	0.15	0.8	18.74	16.33	0.38	N	0.86	polymorphism	1	0.02	rs878928689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8513	8513	C	G	MI.1759	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	148	50	P	A	Ccc/Gcc	-4.27	0	0	probably_damaging	0.99	neutral	0.53	neutral	1.79	deleterious	-6.3	deleterious	-6.24	medium_impact	2.45	0.98	neutral	0.63	neutral	2.06	16.58	deleterious	0.44721401	0.85	0.45	neutral	0.17	neutral	0.63	disease	0.18	neutral	6	0.99	deleterious	0.27	neutral	1	deleterious	0.75	deleterious	-2.65	low_impact	0.32	medium_impact	1	medium_impact	0.66	0.85	1.47	8.21	0.38	N	0.68	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11361	11361	T	A	MI.17590	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	602	201	M	K	aTa/aAa	0.26	0	0	possibly_damaging	0.9	deleterious	0	neutral	4.54	neutral	-2.69	deleterious	-4.01	high_impact	3.52	0.73	neutral	0.43	neutral	4.19	23.80	deleterious	0.03	0.35	0.46	neutral	0.91	disease	0.68	disease	0.8	disease	6	1	deleterious	0.05	neutral	5	deleterious	0.79	deleterious	-1.61	low_impact	-1.48	low_impact	2.36	high_impact	0.14	0.8	18.74	16.33	0.44	N	0.95	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11361	11361	T	C	MI.17591	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	602	201	M	T	aTa/aCa	0.26	0	0	possibly_damaging	0.79	neutral	0.08	neutral	4.61	neutral	-0.94	deleterious	-3.55	low_impact	1.55	0.71	neutral	0.88	neutral	1.77	14.83	neutral	0.1	0.4	0.32	neutral	0.7	disease	0.45	neutral	0.53	disease	1	0.95	neutral	0.15	neutral	-3	neutral	0.71	deleterious	-1.26	low_impact	-0.39	medium_impact	0.41	medium_impact	0.13	0.8	18.74	16.33	0.4	N	0.53	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11362	11362	A	T	MI.17592	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	603	201	M	I	atA/atT	2.33	0.05	0.01	possibly_damaging	0.54	neutral	0.39	neutral	4.74	neutral	1.86	neutral	-1.59	low_impact	1.36	0.71	neutral	0.69	neutral	1.57	13.70	neutral	0.24	0.45	0.33	neutral	0.73	disease	0.42	neutral	0.53	disease	1	0.61	neutral	0.43	neutral	-3	neutral	0.67	deleterious	-0.78	medium_impact	0.09	medium_impact	0.22	medium_impact	0.21	0.8	18.74	16.33	0.42	N	0.89	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11362	11362	A	C	MI.17593	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	603	201	M	I	atA/atC	2.33	0.05	0.01	possibly_damaging	0.54	neutral	0.39	neutral	4.74	neutral	1.86	neutral	-1.59	low_impact	1.36	0.71	neutral	0.69	neutral	1.41	12.83	neutral	0.24	0.45	0.33	neutral	0.73	disease	0.42	neutral	0.53	disease	1	0.61	neutral	0.43	neutral	-3	neutral	0.67	deleterious	-0.78	medium_impact	0.09	medium_impact	0.22	medium_impact	0.21	0.8	18.74	16.33	0.42	N	0.89	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11363	11363	G	T	MI.17594	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	604	202	A	S	Gct/Tct	-0.89	0	0	possibly_damaging	0.86	neutral	0.22	neutral	4.33	neutral	-2.65	neutral	-2.31	medium_impact	2.29	0.64	neutral	0.53	neutral	3.65	23.20	deleterious	0.14	0.4	0.59	disease	0.81	disease	0.55	disease	0.68	disease	4	0.9	neutral	0.18	neutral	0	NA	0.81	deleterious	-1.46	low_impact	-0.11	medium_impact	1.14	medium_impact	0.42	0.8	47.06	9.36	0.38	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11363	11363	G	A	MI.17595	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	604	202	A	T	Gct/Act	-0.89	0	0	probably_damaging	0.95	deleterious	0.01	neutral	4.24	deleterious	-3.39	deleterious	-3.09	high_impact	3.53	0.63	neutral	0.53	neutral	4.16	23.80	deleterious	0.1	0.4	0.67	disease	0.83	disease	0.65	disease	0.67	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.84	deleterious	-1.92	low_impact	-0.92	medium_impact	2.37	high_impact	0.59	0.8	47.06	9.36	0.37	N	0.82	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11363	11363	G	C	MI.17596	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	604	202	A	P	Gct/Cct	-0.89	0	0	probably_damaging	0.99	deleterious	0	neutral	4.18	deleterious	-5.28	deleterious	-3.86	medium_impact	3.37	0.64	neutral	0.47	neutral	3.75	23.30	deleterious	0.04	0.35	0.79	disease	0.87	disease	0.77	disease	0.82	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.86	deleterious	-2.59	low_impact	-1.48	low_impact	2.21	high_impact	0.33	0.8	47.06	9.36	0.37	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11364	11364	C	T	MI.17597	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	605	202	A	V	gCt/gTt	9.01	1	0	probably_damaging	0.96	neutral	0.1	neutral	4.21	neutral	-1.72	deleterious	-3.09	medium_impact	2.73	0.58	damaging	0.48	neutral	4.36	24.10	deleterious	0.07	0.35	0.78	disease	0.84	disease	0.59	disease	0.61	disease	2	0.99	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-2.01	low_impact	-0.33	medium_impact	1.58	medium_impact	0.55	0.8	47.06	9.36	0.65	P	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11364	11364	C	G	MI.17598	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	605	202	A	G	gCt/gGt	9.01	1	0	benign	0.15	neutral	0.09	neutral	4.53	neutral	0.76	deleterious	-3.08	medium_impact	2.19	0.6	damaging	0.61	neutral	3.88	23.50	deleterious	0.18	0.45	0.66	disease	0.76	disease	0.61	disease	0.64	disease	3	0.9	neutral	0.47	deleterious	-3	neutral	0.79	deleterious	-0.01	medium_impact	-0.36	medium_impact	1.04	medium_impact	0.62	0.8	47.06	9.36	0.61	P	0.79	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11364	11364	C	A	MI.17599	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	605	202	A	D	gCt/gAt	9.01	1	0	probably_damaging	0.98	deleterious	0	neutral	4.18	deleterious	-5.57	deleterious	-4.63	high_impact	4.34	0.69	neutral	0.43	neutral	4.53	24.30	deleterious	0.03	0.35	0.49	neutral	0.91	disease	0.75	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.31	low_impact	-1.48	low_impact	3.17	high_impact	0.27	0.8	47.06	9.36	0.59	P	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8608	8608	C	T	MI.176	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	82	28	P	S	Cct/Tct	-10.98	0	0	benign	0.02	neutral	0.26	neutral	4.46	neutral	2.22	neutral	1.46	neutral_impact	-0.78	0.92	neutral	0.96	neutral	-0.02	2.37	deleterious	0.58	0.7	0.24	neutral	0.16	neutral	0.25	neutral	0.3	neutral	4	0.73	neutral	0.62	deleterious	-6	neutral	0.14	neutral	0.85	medium_impact	0.04	medium_impact	-1.77	low_impact	0.39	0.9	31.86	20.94	0.41	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8514	8514	C	G	MI.1760	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	149	50	P	R	cCc/cGc	0.59	0.09	0	probably_damaging	1	neutral	0.34	neutral	1.63	deleterious	-7.55	deleterious	-6.78	medium_impact	2.59	0.98	neutral	0.52	neutral	2.52	19.57	deleterious	0.42653776	0.85	0.76	disease	0.36	neutral	0.66	disease	0.25	neutral	5	1	deleterious	0.17	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.13	medium_impact	1.12	medium_impact	0.56	0.85	1.47	8.21	0.5	N	0.66	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11366	11366	T	G	MI.17600	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	607	203	F	V	Ttt/Gtt	-8.95	0	0	probably_damaging	1	deleterious	0	neutral	4.51	deleterious	-3.34	deleterious	-5.4	high_impact	4.53	0.5	damaging	0.1	damaging	4.03	23.70	deleterious	0.09	0.35	0.21	neutral	0.87	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.72	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.19	0.8	47.49	9.13	0.45	N	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11366	11366	T	C	MI.17601	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	607	203	F	L	Ttt/Ctt	-8.95	0	0	probably_damaging	1	neutral	0.06	neutral	4.76	neutral	-2.17	deleterious	-4.63	medium_impact	3.08	0.49	damaging	0.1	damaging	3.97	23.60	deleterious	0.16	0.45	0.28	neutral	0.82	disease	0.62	disease	0.7	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.47	medium_impact	1.92	medium_impact	0.38	0.8	47.49	9.13	0.37	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11366	11366	T	A	MI.17602	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	607	203	F	I	Ttt/Att	-8.95	0	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-3.31	deleterious	-4.63	medium_impact	3.49	0.52	damaging	0.11	damaging	4.35	24.10	deleterious	0.11	0.4	0.22	neutral	0.86	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.73	deleterious	-3.54	low_impact	-1.48	low_impact	2.33	high_impact	0.30	0.8	47.49	9.13	0.37	N	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11367	11367	T	G	MI.17603	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	608	203	F	C	tTt/tGt	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.39	deleterious	-5.25	deleterious	-6.17	high_impact	4.53	0.51	damaging	0.07	damaging	4.04	23.70	deleterious	0.04	0.35	0.68	disease	0.84	disease	0.72	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.16	0.8	47.49	9.13	0.57	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11367	11367	T	C	MI.17604	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	608	203	F	S	tTt/tCt	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-4.84	deleterious	-6.17	high_impact	4.53	0.5	damaging	0.12	damaging	4.13	23.80	deleterious	0.03	0.35	0.32	neutral	0.83	disease	0.69	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.23	0.8	47.49	9.13	0.53	P	0.93	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11367	11367	T	A	MI.17605	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	608	203	F	Y	tTt/tAt	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-4.14	neutral	-2.31	high_impact	3.98	0.5	damaging	0.09	damaging	4.14	23.80	deleterious	0.12	0.4	0.42	neutral	0.77	disease	0.66	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.54	low_impact	-1.48	low_impact	2.81	high_impact	0.49	0.8	47.49	9.13	0.57	P	0.88	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11368	11368	T	A	MI.17606	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	609	203	F	L	ttT/ttA	7.4	1	0	probably_damaging	1	neutral	0.06	neutral	4.76	neutral	-2.17	deleterious	-4.63	medium_impact	3.08	0.49	damaging	0.1	damaging	4.40	24.10	deleterious	0.16	0.45	0.28	neutral	0.82	disease	0.62	disease	0.7	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.47	medium_impact	1.92	medium_impact	0.38	0.8	47.49	9.13	0.59	P	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11368	11368	T	G	MI.17607	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	609	203	F	L	ttT/ttG	7.4	1	0	probably_damaging	1	neutral	0.06	neutral	4.76	neutral	-2.17	deleterious	-4.63	medium_impact	3.08	0.49	damaging	0.1	damaging	4.27	24.00	deleterious	0.16	0.45	0.28	neutral	0.82	disease	0.62	disease	0.7	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.47	medium_impact	1.92	medium_impact	0.38	0.8	47.49	9.13	0.59	P	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11369	11369	A	T	MI.17608	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	610	204	M	L	Ata/Tta	-3.42	0	0	benign	0.04	neutral	1	neutral	4.78	neutral	0.52	neutral	-0.96	neutral_impact	-0.4	0.71	neutral	0.95	neutral	0.56	7.89	deleterious	0.31	0.45	0.29	neutral	0.4	neutral	0.34	neutral	0.44	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.52	deleterious	0.58	medium_impact	1.88	high_impact	-1.52	low_impact	0.29	0.8	44.23	9.11	0.29	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11369	11369	A	C	MI.17609	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	610	204	M	L	Ata/Cta	-3.42	0	0	benign	0.04	neutral	1	neutral	4.78	neutral	0.52	neutral	-0.96	neutral_impact	-0.4	0.71	neutral	0.95	neutral	0.50	7.40	deleterious	0.31	0.45	0.29	neutral	0.4	neutral	0.34	neutral	0.44	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.52	deleterious	0.58	medium_impact	1.88	high_impact	-1.52	low_impact	0.29	0.8	44.23	9.11	0.29	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8514	8514	C	A	MI.1761	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	149	50	P	H	cCc/cAc	0.59	0.09	0	probably_damaging	1	neutral	0.54	neutral	1.61	deleterious	-8.63	deleterious	-7.06	medium_impact	2.17	0.97	neutral	0.54	neutral	4.22	23.90	deleterious	0.47136521	0.85	0.86	disease	0.3	neutral	0.65	disease	0.19	neutral	6	1	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.33	medium_impact	0.76	medium_impact	0.58	0.85	1.47	8.21	0.43	N	0.80	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11369	11369	A	G	MI.17610	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	610	204	M	V	Ata/Gta	-3.42	0	0	possibly_damaging	0.62	deleterious	0.03	neutral	4.62	neutral	-0.37	neutral	-2.27	medium_impact	2.55	0.78	neutral	0.19	damaging	2.65	20.50	deleterious	0.28	0.45	0.33	neutral	0.87	disease	0.57	disease	0.73	disease	5	0.97	neutral	0.21	neutral	4	deleterious	0.66	deleterious	-0.92	medium_impact	-0.64	medium_impact	1.4	medium_impact	0.29	0.8	44.23	9.11	0.29	N	0.87	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11370	11370	T	A	MI.17611	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	611	204	M	K	aTa/aAa	0.26	0.02	0	probably_damaging	0.92	deleterious	0	neutral	4.5	neutral	-2.33	deleterious	-4.09	medium_impact	3.36	0.64	neutral	0.13	damaging	3.85	23.40	deleterious	0.03	0.35	0.6	disease	0.93	disease	0.71	disease	0.84	disease	7	1	deleterious	0.04	neutral	5	deleterious	0.83	deleterious	-1.71	low_impact	-1.48	low_impact	2.2	high_impact	0.17	0.8	44.23	9.11	0.33	N	0.94	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11370	11370	T	C	MI.17612	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	611	204	M	T	aTa/aCa	0.26	0.02	0	possibly_damaging	0.84	deleterious	0	neutral	4.55	neutral	-1.19	deleterious	-3.82	medium_impact	2.55	0.67	neutral	0.18	damaging	2.89	21.80	deleterious	0.13	0.4	0.47	neutral	0.87	disease	0.63	disease	0.77	disease	5	1	deleterious	0.08	neutral	4	deleterious	0.79	deleterious	-1.39	low_impact	-1.48	low_impact	1.4	medium_impact	0.19	0.8	44.23	9.11	0.32	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11371	11371	A	T	MI.17613	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	612	204	M	I	atA/atT	5.78	0.99	0	possibly_damaging	0.62	neutral	0.12	neutral	4.6	neutral	-0.4	neutral	-2	medium_impact	2.38	0.69	neutral	0.15	damaging	3.48	23.10	deleterious	0.22	0.45	0.26	neutral	0.89	disease	0.45	neutral	0.68	disease	4	0.88	neutral	0.25	neutral	0	NA	0.69	deleterious	-0.92	medium_impact	-0.28	medium_impact	1.23	medium_impact	0.31	0.8	44.23	9.11	0.57	P	0.89	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11371	11371	A	C	MI.17614	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	612	204	M	I	atA/atC	5.78	0.99	0	possibly_damaging	0.62	neutral	0.12	neutral	4.6	neutral	-0.4	neutral	-2	medium_impact	2.38	0.69	neutral	0.15	damaging	3.32	22.90	deleterious	0.22	0.45	0.26	neutral	0.89	disease	0.45	neutral	0.68	disease	4	0.88	neutral	0.25	neutral	0	NA	0.69	deleterious	-0.92	medium_impact	-0.28	medium_impact	1.23	medium_impact	0.31	0.8	44.23	9.11	0.57	P	0.89	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11372	11372	G	C	MI.17615	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	613	205	V	L	Gta/Cta	0.49	0.98	0	benign	0.18	deleterious	0	neutral	4.6	neutral	-1.47	neutral	-2.15	high_impact	3.66	0.68	neutral	0.58	neutral	1.57	13.68	neutral	0.24	0.45	0.23	neutral	0.82	disease	0.57	disease	0.7	disease	4	1	deleterious	0.41	neutral	2	deleterious	0.23	neutral	-0.1	medium_impact	-1.48	low_impact	2.5	high_impact	0.42	0.8	23.31	17.27	0.55	P	0.58	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11372	11372	G	T	MI.17616	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	613	205	V	L	Gta/Tta	0.49	0.98	0	benign	0.18	deleterious	0	neutral	4.6	neutral	-1.47	neutral	-2.15	high_impact	3.66	0.68	neutral	0.58	neutral	1.72	14.54	neutral	0.24	0.45	0.23	neutral	0.82	disease	0.57	disease	0.7	disease	4	1	deleterious	0.41	neutral	2	deleterious	0.23	neutral	-0.1	medium_impact	-1.48	low_impact	2.5	high_impact	0.42	0.8	23.31	17.27	0.55	P	0.58	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11372	11372	G	A	MI.17617	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	613	205	V	M	Gta/Ata	0.49	0.98	0	benign	0.29	neutral	0.07	neutral	4.44	deleterious	-3.04	neutral	-2.23	medium_impact	3.31	0.71	neutral	0.67	neutral	1.77	14.82	neutral	0.19	0.45	0.27	neutral	0.81	disease	0.61	disease	0.7	disease	4	0.92	neutral	0.39	neutral	-3	neutral	0.20	neutral	-0.35	medium_impact	-0.43	medium_impact	2.15	high_impact	0.58	0.8	23.31	17.27	0.52	N	0.57	polymorphism	1	0.08	.	.	.	.	.	.	COSM1155505	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11373	11373	T	G	MI.17618	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	614	205	V	G	gTa/gGa	2.79	1	0	possibly_damaging	0.73	deleterious	0	neutral	4.47	neutral	-1.08	deleterious	-5.37	high_impact	4.36	0.68	neutral	0.63	neutral	3.36	22.90	deleterious	0.02	0.35	0.76	disease	0.84	disease	0.62	disease	0.73	disease	5	1	deleterious	0.14	neutral	5	deleterious	0.61	deleterious	-1.12	low_impact	-1.48	low_impact	3.19	high_impact	0.23	0.8	23.31	17.27	0.55	P	0.93	polymorphism	1	0.17	.	.	.	.	.	.	COSM1169172	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11373	11373	T	C	MI.17619	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	614	205	V	A	gTa/gCa	2.79	1	0	benign	0.4	deleterious	0.02	neutral	4.49	neutral	-1.17	deleterious	-3.06	medium_impact	2.56	0.73	neutral	0.66	neutral	1.75	14.69	neutral	0.1	0.4	0.4	neutral	0.64	disease	0.44	neutral	0.45	neutral	1	0.98	neutral	0.31	neutral	1	deleterious	0.31	neutral	-0.55	medium_impact	-0.75	medium_impact	1.41	medium_impact	0.15	0.8	23.31	17.27	0.55	P	0.69	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8514	8514	C	T	MI.1762	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	149	50	P	L	cCc/cTc	0.59	0.09	0	probably_damaging	1	neutral	0.66	neutral	1.64	deleterious	-7.4	deleterious	-7.97	medium_impact	3.14	1	neutral	0.35	neutral	4.36	24.10	deleterious	0.59098804	0.85	0.75	disease	0.34	neutral	0.62	disease	0.24	neutral	5	1	deleterious	0.33	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.45	medium_impact	1.59	medium_impact	0.66	0.85	1.47	8.21	0.42	N	0.86	polymorphism	0.79	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11373	11373	T	A	MI.17620	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	614	205	V	E	gTa/gAa	2.79	1	0	possibly_damaging	0.86	deleterious	0	neutral	4.4	deleterious	-4.87	deleterious	-4.61	high_impact	4.36	0.71	neutral	0.52	neutral	4.41	24.10	deleterious	0.02	0.35	0.78	disease	0.89	disease	0.71	disease	0.78	disease	6	1	deleterious	0.07	neutral	5	deleterious	0.73	deleterious	-1.46	low_impact	-1.48	low_impact	3.19	high_impact	0.17	0.8	23.31	17.27	0.59	P	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11375	11375	A	G	MI.17621	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	616	206	K	E	Aag/Gag	-6.88	0	0	probably_damaging	1	deleterious	0	neutral	3.17	deleterious	-6.03	deleterious	-3.04	high_impact	4.54	0.65	neutral	0.2	damaging	4.00	23.60	deleterious	0.04	0.35	0.41	neutral	0.85	disease	0.78	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.26	0.8	47.71	9.43	0.54	N	0.87	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11375	11375	A	C	MI.17622	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	616	206	K	Q	Aag/Cag	-6.88	0	0	probably_damaging	1	deleterious	0	neutral	3.17	deleterious	-6.01	deleterious	-3.06	high_impact	4.54	0.65	neutral	0.2	damaging	3.44	23.00	deleterious	0.07	0.35	0.48	neutral	0.8	disease	0.77	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.32	0.8	47.71	9.43	0.52	N	0.86	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	A11375C	found in 1 sCJD patient	+	-	Reported	1	.	P	P	damaging
chrM	11376	11376	A	T	MI.17623	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	617	206	K	M	aAg/aTg	8.55	1	0	probably_damaging	1	deleterious	0	neutral	3.13	deleterious	-8.49	deleterious	-4.61	high_impact	4.54	0.69	neutral	0.17	damaging	3.79	23.40	deleterious	0.03	0.35	0.53	disease	0.85	disease	0.77	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.19	0.8	47.71	9.43	0.57	P	0.42	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11376	11376	A	C	MI.17624	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	617	206	K	T	aAg/aCg	8.55	1	0	probably_damaging	1	deleterious	0	neutral	3.15	deleterious	-6.82	deleterious	-4.6	high_impact	4.54	0.69	neutral	0.16	damaging	3.54	23.10	deleterious	0.04	0.35	0.26	neutral	0.83	disease	0.76	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.21	0.8	47.71	9.43	0.58	P	0.77	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11377	11377	G	C	MI.17625	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	618	206	K	N	aaG/aaC	8.55	1	0.03	probably_damaging	1	deleterious	0	neutral	3.18	deleterious	-6.71	deleterious	-3.83	high_impact	4.2	0.64	neutral	0.16	damaging	3.91	23.50	deleterious	0.07	0.35	0.51	disease	0.82	disease	0.77	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.21	0.8	47.71	9.43	0.6	P	0.72	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11377	11377	G	T	MI.17626	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	618	206	K	N	aaG/aaT	8.55	1	0.03	probably_damaging	1	deleterious	0	neutral	3.18	deleterious	-6.71	deleterious	-3.83	high_impact	4.2	0.64	neutral	0.16	damaging	4.06	23.70	deleterious	0.07	0.35	0.51	disease	0.82	disease	0.77	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.21	0.8	47.71	9.43	0.6	P	0.72	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11378	11378	A	C	MI.17627	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	619	207	M	L	Ata/Cta	2.1	1	0	benign	0.04	neutral	0.51	neutral	4.84	neutral	1.01	neutral	-2	neutral_impact	0.44	0.7	neutral	0.76	neutral	2.95	22.00	deleterious	0.32	0.5	0.34	neutral	0.75	disease	0.53	disease	0.52	disease	0	0.45	neutral	0.74	deleterious	-6	neutral	0.61	deleterious	0.58	medium_impact	0.21	medium_impact	-0.69	medium_impact	0.34	0.8	28.76	8.32	0.4	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11378	11378	A	G	MI.17628	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	619	207	M	V	Ata/Gta	2.1	1	0	possibly_damaging	0.62	neutral	0.06	neutral	4.68	neutral	0.8	deleterious	-2.88	low_impact	1.88	0.7	neutral	0.56	neutral	2.51	19.52	deleterious	0.23	0.45	0.35	neutral	0.86	disease	0.72	disease	0.77	disease	5	0.94	neutral	0.22	neutral	-3	neutral	0.68	deleterious	-0.92	medium_impact	-0.47	medium_impact	0.73	medium_impact	0.41	0.8	28.76	8.32	0.42	N	0.96	polymorphism	1	0.06	rs879106171	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11378	11378	A	T	MI.17629	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	619	207	M	L	Ata/Tta	2.1	1	0	benign	0.04	neutral	0.51	neutral	4.84	neutral	1.01	neutral	-2	neutral_impact	0.44	0.7	neutral	0.76	neutral	3.02	22.30	deleterious	0.32	0.5	0.34	neutral	0.75	disease	0.53	disease	0.52	disease	0	0.45	neutral	0.74	deleterious	-6	neutral	0.61	deleterious	0.58	medium_impact	0.21	medium_impact	-0.69	medium_impact	0.34	0.8	28.76	8.32	0.42	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8516	8516	T	G	MI.1763	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	151	51	W	G	Tga/Gga	-4.5	0	0	probably_damaging	0.98	neutral	0.57	neutral	1.49	deleterious	-7.42	deleterious	-12.04	high_impact	3.79	0.95	neutral	0.44	neutral	3.97	23.60	deleterious	0.21986021	0.85	0.85	disease	0.6	disease	0.75	disease	0.68	disease	4	0.98	deleterious	0.3	neutral	2	deleterious	0.86	deleterious	-2.36	low_impact	0.36	medium_impact	2.15	high_impact	0.18	0.85	17.65	8.71	0.45	N	0.93	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11379	11379	T	C	MI.17630	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	620	207	M	T	aTa/aCa	3.02	1	0	possibly_damaging	0.84	deleterious	0.04	neutral	4.62	neutral	-0.54	deleterious	-4.41	medium_impact	2.17	0.72	neutral	0.63	neutral	2.90	21.90	deleterious	0.13	0.4	0.33	neutral	0.86	disease	0.68	disease	0.7	disease	4	0.98	neutral	0.1	neutral	4	deleterious	0.78	deleterious	-1.39	low_impact	-0.57	medium_impact	1.02	medium_impact	0.13	0.8	28.76	8.32	0.49	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11379	11379	T	A	MI.17631	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	620	207	M	K	aTa/aAa	3.02	1	0	probably_damaging	0.92	deleterious	0	neutral	4.57	neutral	-2.67	deleterious	-4.48	high_impact	3.84	0.69	neutral	0.46	neutral	3.92	23.50	deleterious	0.03	0.35	0.36	neutral	0.92	disease	0.79	disease	0.81	disease	6	1	deleterious	0.04	neutral	6	deleterious	0.81	deleterious	-1.71	low_impact	-1.48	low_impact	2.67	high_impact	0.13	0.8	28.76	8.32	0.58	P	1.00	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11380	11380	A	C	MI.17632	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	621	207	M	I	atA/atC	4.63	1	0.01	possibly_damaging	0.62	neutral	0.51	neutral	4.79	neutral	0.34	deleterious	-2.82	low_impact	1.75	0.74	neutral	0.62	neutral	3.37	22.90	deleterious	0.25	0.45	0.4	neutral	0.87	disease	0.56	disease	0.54	disease	1	0.6	neutral	0.45	neutral	-3	neutral	0.75	deleterious	-0.92	medium_impact	0.21	medium_impact	0.61	medium_impact	0.41	0.8	28.76	8.32	0.51	N	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11380	11380	A	T	MI.17633	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	621	207	M	I	atA/atT	4.63	1	0.01	possibly_damaging	0.62	neutral	0.51	neutral	4.79	neutral	0.34	deleterious	-2.82	low_impact	1.75	0.74	neutral	0.62	neutral	3.45	23.00	deleterious	0.25	0.45	0.4	neutral	0.87	disease	0.56	disease	0.54	disease	1	0.6	neutral	0.45	neutral	-3	neutral	0.75	deleterious	-0.92	medium_impact	0.21	medium_impact	0.61	medium_impact	0.41	0.8	28.76	8.32	0.53	P	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11381	11381	C	T	MI.17634	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	622	208	P	S	Cct/Tct	-0.89	0.02	0	probably_damaging	1	deleterious	0	neutral	4.51	neutral	-1.51	deleterious	-6.16	high_impact	4.2	0.47	damaging	0.1	damaging	3.88	23.50	deleterious	0.07	0.35	0.3	neutral	0.81	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.10	0.8	46.84	9.48	0.46	N	0.71	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11381	11381	C	G	MI.17635	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	622	208	P	A	Cct/Gct	-0.89	0.02	0	probably_damaging	1	deleterious	0.01	neutral	4.73	neutral	1.42	deleterious	-6.16	high_impact	3.58	0.47	damaging	0.11	damaging	3.06	22.40	deleterious	0.14	0.4	0.35	neutral	0.72	disease	0.68	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.54	low_impact	-0.92	medium_impact	2.42	high_impact	0.55	0.8	46.84	9.48	0.4	N	0.77	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11381	11381	C	A	MI.17636	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	622	208	P	T	Cct/Act	-0.89	0.02	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-3.62	deleterious	-6.16	high_impact	4.55	0.52	damaging	0.08	damaging	3.69	23.30	deleterious	0.05	0.35	0.4	neutral	0.83	disease	0.69	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.39	0.8	46.84	9.48	0.43	N	0.89	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11382	11382	C	G	MI.17637	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	623	208	P	R	cCt/cGt	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.34	deleterious	-4.98	deleterious	-6.93	high_impact	4.55	0.56	damaging	0.07	damaging	3.53	23.10	deleterious	0.03	0.35	0.59	disease	0.91	disease	0.79	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.20	0.8	46.84	9.48	0.61	P	0.58	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11382	11382	C	T	MI.17638	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	623	208	P	L	cCt/cTt	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.34	deleterious	-3.91	deleterious	-7.7	high_impact	4.2	0.47	damaging	0.06	damaging	4.24	23.90	deleterious	0.03	0.35	0.25	neutral	0.89	disease	0.68	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.57	0.8	46.84	9.48	0.6	P	0.97	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11382	11382	C	A	MI.17639	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	623	208	P	H	cCt/cAt	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.33	deleterious	-5.98	deleterious	-6.92	high_impact	4.55	0.49	damaging	0.06	damaging	4.02	23.60	deleterious	0.04	0.35	0.67	disease	0.86	disease	0.79	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.24	0.8	46.84	9.48	0.59	P	0.70	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8516	8516	T	C	MI.1764	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	151	51	W	R	Tga/Cga	-4.5	0	0	probably_damaging	1	neutral	0.69	neutral	1.47	deleterious	-7.63	deleterious	-12.77	high_impact	3.79	0.91	neutral	0.27	damaging	3.61	23.20	deleterious	0.25608775	0.85	0.89	disease	0.65	disease	0.78	disease	0.67	disease	3	0.99	deleterious	0.35	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.49	medium_impact	2.15	high_impact	0.17	0.85	17.65	8.71	0.45	N	0.97	polymorphism	1	0.41	rs878928585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11384	11384	C	T	MI.17640	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	625	209	L	F	Ctt/Ttt	-9.41	0	0	probably_damaging	1	deleterious	0.02	neutral	4.46	deleterious	-3.21	deleterious	-3	medium_impact	3.12	0.67	neutral	0.15	damaging	3.95	23.60	deleterious	0.12	0.4	0.57	disease	0.66	disease	0.65	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.75	medium_impact	1.96	medium_impact	0.52	0.8	46.19	8.18	0.29	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11384	11384	C	A	MI.17641	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	625	209	L	I	Ctt/Att	-9.41	0	0	probably_damaging	1	neutral	0.27	neutral	4.6	neutral	-1.17	neutral	-1.5	low_impact	1.69	0.74	neutral	0.26	damaging	4.14	23.80	deleterious	0.3	0.45	0.22	neutral	0.58	disease	0.35	neutral	0.45	neutral	1	1	deleterious	0.14	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	-0.04	medium_impact	0.55	medium_impact	0.61	0.8	46.19	8.18	0.34	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11384	11384	C	G	MI.17642	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	625	209	L	V	Ctt/Gtt	-9.41	0	0	probably_damaging	1	neutral	0.34	neutral	4.56	neutral	-1.44	neutral	-2.23	low_impact	1.77	0.77	neutral	0.19	damaging	3.45	23.00	deleterious	0.28	0.45	0.36	neutral	0.6	disease	0.53	disease	0.47	neutral	1	1	deleterious	0.17	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	0.04	medium_impact	0.63	medium_impact	0.50	0.8	46.19	8.18	0.26	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11385	11385	T	A	MI.17643	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	626	209	L	H	cTt/cAt	-0.66	0	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-5.24	deleterious	-5.27	high_impact	3.82	0.71	neutral	0.13	damaging	4.00	23.60	deleterious	0.05	0.35	0.2	neutral	0.8	disease	0.67	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	2.65	high_impact	0.24	0.8	46.19	8.18	0.37	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11385	11385	T	C	MI.17644	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	626	209	L	P	cTt/cCt	-0.66	0	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-4.97	deleterious	-5.27	high_impact	3.82	0.61	neutral	0.14	damaging	3.68	23.30	deleterious	0.02	0.35	0.73	disease	0.84	disease	0.65	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	2.65	high_impact	0.13	0.8	46.19	8.18	0.32	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11385	11385	T	G	MI.17645	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	626	209	L	R	cTt/cGt	-0.66	0	0	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-4.69	deleterious	-4.5	high_impact	3.82	0.61	neutral	0.13	damaging	3.97	23.60	deleterious	0.03	0.35	0.6	disease	0.91	disease	0.76	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.65	high_impact	0.16	0.8	46.19	8.18	0.39	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11387	11387	T	C	MI.17646	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	628	210	Y	H	Tac/Cac	-3.19	0	0	probably_damaging	1	deleterious	0	neutral	4.53	neutral	-1.82	deleterious	-3.85	high_impact	4.16	0.49	damaging	0.06	damaging	3.51	23.10	deleterious	0.15	0.45	0.74	disease	0.79	disease	0.8	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.99	high_impact	0.18	0.8	47.28	9.26	0.45	N	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11387	11387	T	G	MI.17647	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	628	210	Y	D	Tac/Gac	-3.19	0	0	probably_damaging	1	deleterious	0	neutral	4.52	neutral	-2.51	deleterious	-7.7	high_impact	4.16	0.47	damaging	0.07	damaging	3.88	23.50	deleterious	0.04	0.35	0.83	disease	0.88	disease	0.8	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.99	high_impact	0.14	0.8	47.28	9.26	0.49	N	0.99	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11387	11387	T	A	MI.17648	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	628	210	Y	N	Tac/Aac	-3.19	0	0	probably_damaging	1	deleterious	0	neutral	4.53	neutral	-1.58	deleterious	-6.93	high_impact	4.16	0.5	damaging	0.07	damaging	3.96	23.60	deleterious	0.08	0.35	0.44	neutral	0.83	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	2.99	high_impact	0.13	0.8	47.28	9.26	0.4	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11388	11388	A	G	MI.17649	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	629	210	Y	C	tAc/tGc	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.53	neutral	-1.63	deleterious	-6.93	high_impact	4.16	0.49	damaging	0.05	damaging	3.52	23.10	deleterious	0.05	0.35	0.9	disease	0.84	disease	0.76	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.99	high_impact	0.09	0.8	47.28	9.26	0.62	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8517	8517	G	C	MI.1765	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	152	51	W	S	tGa/tCa	7.53	1	0	probably_damaging	0.99	neutral	0.9	neutral	1.64	deleterious	-7.53	deleterious	-12.81	high_impact	3.79	0.9	neutral	0.38	neutral	4.08	23.70	deleterious	0.18580261	0.85	0.88	disease	0.71	disease	0.75	disease	0.76	disease	5	0.99	deleterious	0.46	neutral	2	deleterious	0.89	deleterious	-2.65	low_impact	0.83	medium_impact	2.15	high_impact	0.19	0.85	17.65	8.71	0.58	P	0.95	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11388	11388	A	T	MI.17650	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	629	210	Y	F	tAc/tTc	5.78	1	0	probably_damaging	1	neutral	0.35	neutral	4.73	neutral	3.73	deleterious	-3.08	low_impact	1.58	0.52	damaging	0.11	damaging	3.35	22.90	deleterious	0.24	0.45	0.46	neutral	0.57	disease	0.55	disease	0.44	neutral	1	1	deleterious	0.18	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	0.05	medium_impact	0.44	medium_impact	0.44	0.8	47.28	9.26	0.58	P	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11388	11388	A	C	MI.17651	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	629	210	Y	S	tAc/tCc	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.57	neutral	-0.2	deleterious	-6.93	high_impact	4.16	0.49	damaging	0.08	damaging	3.71	23.30	deleterious	0.06	0.35	0.73	disease	0.81	disease	0.71	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.99	high_impact	0.18	0.8	47.28	9.26	0.62	P	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11390	11390	G	C	MI.17652	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	631	211	G	R	Gga/Cga	-6.19	0	0	probably_damaging	1	neutral	0.34	neutral	4.55	neutral	-2.52	deleterious	-6.15	high_impact	3.76	0.63	neutral	0.3	neutral	3.96	23.60	deleterious	0.02	0.35	0.6	disease	0.92	disease	0.8	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	0.04	medium_impact	2.59	high_impact	0.41	0.8	47.49	9.47	0.4	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11390	11390	G	T	MI.17653	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	631	211	G	W	Gga/Tga	-6.19	0	0	probably_damaging	1	neutral	0.18	neutral	4.53	deleterious	-4.79	deleterious	-6.15	medium_impact	3.21	0.68	neutral	0.28	damaging	4.42	24.20	deleterious	0.04	0.35	0.77	disease	0.92	disease	0.75	disease	0.82	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.17	medium_impact	2.05	high_impact	0.11	0.8	47.49	9.47	0.28	N	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11391	11391	G	T	MI.17654	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	632	211	G	V	gGa/gTa	2.56	0.99	0	probably_damaging	1	neutral	0.5	neutral	4.59	neutral	-1.32	deleterious	-6.92	medium_impact	2.87	0.67	neutral	0.33	neutral	3.70	23.30	deleterious	0.03	0.35	0.23	neutral	0.89	disease	0.69	disease	0.76	disease	5	1	deleterious	0.25	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.2	medium_impact	1.71	medium_impact	0.16	0.8	47.49	9.47	0.44	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11391	11391	G	C	MI.17655	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	632	211	G	A	gGa/gCa	2.56	0.99	0	probably_damaging	1	neutral	0.51	neutral	4.62	neutral	-1.15	deleterious	-4.61	medium_impact	3.07	0.7	neutral	0.43	neutral	3.07	22.40	deleterious	0.08	0.35	0.22	neutral	0.74	disease	0.68	disease	0.68	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.21	medium_impact	1.91	medium_impact	0.40	0.8	47.49	9.47	0.49	N	0.76	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11391	11391	G	A	MI.17656	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	632	211	G	E	gGa/gAa	2.56	0.99	0	probably_damaging	1	neutral	0.27	neutral	4.56	neutral	-2.71	deleterious	-6.15	high_impact	3.76	0.67	neutral	0.35	neutral	3.81	23.40	deleterious	0.02	0.35	0.63	disease	0.88	disease	0.79	disease	0.84	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	-0.04	medium_impact	2.59	high_impact	0.23	0.8	47.49	9.47	0.59	P	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11393	11393	C	A	MI.17657	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	634	212	L	I	Ctc/Atc	-9.64	0	0	possibly_damaging	0.51	neutral	0.17	neutral	4.19	neutral	-2.91	neutral	-0.4	medium_impact	2.19	0.75	neutral	0.75	neutral	1.04	10.88	neutral	0.23	0.45	0.43	neutral	0.54	disease	0.33	neutral	0.49	neutral	0	0.81	neutral	0.33	neutral	0	NA	0.26	neutral	-0.73	medium_impact	-0.18	medium_impact	1.04	medium_impact	0.57	0.8	20.7	24.37	0.45	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11393	11393	C	G	MI.17658	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	634	212	L	V	Ctc/Gtc	-9.64	0	0	benign	0.08	neutral	1	neutral	4.23	neutral	-2.31	neutral	-0.7	neutral_impact	0.46	0.73	neutral	0.93	neutral	-0.99	0.02	neutral	0.24	0.45	0.41	neutral	0.14	neutral	0.29	neutral	0.26	neutral	5	0.08	neutral	0.96	deleterious	-6	neutral	0.16	neutral	0.28	medium_impact	1.88	high_impact	-0.67	medium_impact	0.63	0.8	20.7	24.37	0.32	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11393	11393	C	T	MI.17659	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	634	212	L	F	Ctc/Ttc	-9.64	0	0	probably_damaging	0.93	neutral	0.79	neutral	4.55	neutral	-0.33	neutral	-2.11	low_impact	1.21	0.76	neutral	0.76	neutral	3.68	23.30	deleterious	0.2	0.45	0.56	disease	0.47	neutral	0.37	neutral	0.61	disease	2	0.92	neutral	0.43	neutral	-2	neutral	0.62	deleterious	-1.77	low_impact	0.52	medium_impact	0.07	medium_impact	0.62	0.8	20.7	24.37	0.22	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8517	8517	G	T	MI.1766	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	152	51	W	L	tGa/tTa	7.53	1	0	probably_damaging	0.98	neutral	0.79	neutral	1.58	deleterious	-6.33	deleterious	-12.07	high_impact	3.79	0.89	neutral	0.34	neutral	4.34	24.00	deleterious	0.25608775	0.85	0.79	disease	0.57	disease	0.75	disease	0.68	disease	4	0.98	deleterious	0.41	neutral	2	deleterious	0.85	deleterious	-2.36	low_impact	0.62	medium_impact	2.15	high_impact	0.12	0.85	17.65	8.71	0.59	P	0.96	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11394	11394	T	G	MI.17660	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	635	212	L	R	cTc/cGc	-1.81	0	0	probably_damaging	0.93	deleterious	0.02	neutral	4.11	deleterious	-5.63	deleterious	-3.86	high_impact	3.7	0.73	neutral	0.44	neutral	4.08	23.70	deleterious	0.01	0.35	0.72	disease	0.9	disease	0.73	disease	0.83	disease	7	0.99	deleterious	0.05	neutral	6	deleterious	0.82	deleterious	-1.77	low_impact	-0.75	medium_impact	2.53	high_impact	0.21	0.8	20.7	24.37	0.36	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11394	11394	T	A	MI.17661	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	635	212	L	H	cTc/cAc	-1.81	0	0	probably_damaging	0.98	deleterious	0.03	neutral	4.11	deleterious	-6.2	deleterious	-4.27	high_impact	3.7	0.74	neutral	0.48	neutral	4.26	23.90	deleterious	0.02	0.35	0.8	disease	0.76	disease	0.69	disease	0.78	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-2.31	low_impact	-0.64	medium_impact	2.53	high_impact	0.38	0.8	20.7	24.37	0.39	N	0.82	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11394	11394	T	C	MI.17662	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	635	212	L	P	cTc/cCc	-1.81	0	0	probably_damaging	0.95	deleterious	0.01	neutral	4.11	deleterious	-6.14	deleterious	-4.16	high_impact	3.7	0.64	neutral	0.4	neutral	3.86	23.50	deleterious	0.02	0.35	0.81	disease	0.87	disease	0.72	disease	0.82	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.85	deleterious	-1.92	low_impact	-0.92	medium_impact	2.53	high_impact	0.29	0.8	20.7	24.37	0.34	N	0.88	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11396	11396	C	G	MI.17663	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	637	213	H	D	Cac/Gac	-12.86	0	0	possibly_damaging	0.83	deleterious	0	neutral	3.98	deleterious	-5.38	deleterious	-6.93	high_impact	4.51	0.62	neutral	0.38	neutral	3.83	23.40	deleterious	0.04	0.35	0.65	disease	0.84	disease	0.87	disease	0.82	disease	6	1	deleterious	0.09	neutral	5	deleterious	0.84	deleterious	-1.37	low_impact	-1.48	low_impact	3.34	high_impact	0.15	0.8	47.71	9.33	0.51	N	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11396	11396	C	A	MI.17664	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	637	213	H	N	Cac/Aac	-12.86	0	0	possibly_damaging	0.8	deleterious	0	neutral	4	deleterious	-4.75	deleterious	-5.39	high_impact	3.62	0.52	damaging	0.42	neutral	3.86	23.50	deleterious	0.11	0.4	0.57	disease	0.81	disease	0.82	disease	0.78	disease	6	1	deleterious	0.1	neutral	5	deleterious	0.83	deleterious	-1.28	low_impact	-1.48	low_impact	2.46	high_impact	0.20	0.8	47.71	9.33	0.44	N	0.97	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11396	11396	C	T	MI.17665	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	637	213	H	Y	Cac/Tac	-12.86	0	0	probably_damaging	0.93	deleterious	0	neutral	4.01	deleterious	-4.86	deleterious	-4.62	high_impact	4.51	0.56	damaging	0.34	neutral	3.67	23.20	deleterious	0.05	0.35	0.53	disease	0.85	disease	0.83	disease	0.81	disease	6	1	deleterious	0.04	neutral	6	deleterious	0.84	deleterious	-1.77	low_impact	-1.48	low_impact	3.34	high_impact	0.27	0.8	47.71	9.33	0.55	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11397	11397	A	G	MI.17666	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	638	213	H	R	cAc/cGc	7.17	1	0	possibly_damaging	0.83	deleterious	0	neutral	3.99	deleterious	-5.27	deleterious	-6.15	high_impact	3.82	0.57	damaging	0.37	neutral	2.96	22.10	deleterious	0.04	0.35	0.54	disease	0.85	disease	0.85	disease	0.82	disease	6	1	deleterious	0.09	neutral	5	deleterious	0.87	deleterious	-1.37	low_impact	-1.48	low_impact	2.65	high_impact	0.30	0.8	47.71	9.33	0.61	P	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11397	11397	A	T	MI.17667	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	638	213	H	L	cAc/cTc	7.17	1	0	possibly_damaging	0.88	deleterious	0	neutral	3.97	deleterious	-5.26	deleterious	-8.47	high_impact	4.51	0.56	damaging	0.45	neutral	3.81	23.40	deleterious	0.03	0.35	0.24	neutral	0.87	disease	0.83	disease	0.82	disease	6	1	deleterious	0.06	neutral	5	deleterious	0.79	deleterious	-1.53	low_impact	-1.48	low_impact	3.34	high_impact	0.17	0.8	47.71	9.33	0.62	P	0.96	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11397	11397	A	C	MI.17668	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	638	213	H	P	cAc/cCc	7.17	1	0	probably_damaging	0.97	deleterious	0	neutral	3.95	deleterious	-6.64	deleterious	-7.7	high_impact	4.51	0.56	damaging	0.37	neutral	3.19	22.70	deleterious	0.02	0.35	0.66	disease	0.86	disease	0.88	disease	0.82	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-2.14	low_impact	-1.48	low_impact	3.34	high_impact	0.12	0.8	47.71	9.33	0.65	P	0.95	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11398	11398	C	G	MI.17669	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	639	213	H	Q	caC/caG	8.55	1	0	benign	0.2	deleterious	0	neutral	4.04	deleterious	-4.06	deleterious	-6.16	high_impact	4.51	0.53	damaging	0.38	neutral	3.57	23.20	deleterious	0.05	0.35	0.55	disease	0.8	disease	0.83	disease	0.78	disease	6	1	deleterious	0.4	neutral	2	deleterious	0.84	deleterious	-0.15	medium_impact	-1.48	low_impact	3.34	high_impact	0.31	0.8	47.71	9.33	0.6	P	0.93	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8518	8518	A	T	MI.1767	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	153	51	W	C	tgA/tgT	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	1.46	deleterious	-9	deleterious	-12.14	high_impact	3.79	0.92	neutral	0.24	damaging	4.23	23.90	deleterious	0.24424793	0.85	0.94	disease	0.65	disease	0.76	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.06	medium_impact	2.15	high_impact	0.18	0.85	17.65	8.71	0.61	P	0.92	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11398	11398	C	A	MI.17670	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	639	213	H	Q	caC/caA	8.55	1	0	benign	0.2	deleterious	0	neutral	4.04	deleterious	-4.06	deleterious	-6.16	high_impact	4.51	0.53	damaging	0.38	neutral	3.85	23.40	deleterious	0.05	0.35	0.55	disease	0.8	disease	0.83	disease	0.78	disease	6	1	deleterious	0.4	neutral	2	deleterious	0.84	deleterious	-0.15	medium_impact	-1.48	low_impact	3.34	high_impact	0.31	0.8	47.71	9.33	0.61	P	0.93	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11399	11399	T	G	MI.17671	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	640	214	L	V	Tta/Gta	-1.35	0	0	probably_damaging	1	neutral	0.05	neutral	4.57	neutral	0.63	neutral	-2.31	medium_impact	2.94	0.42	damaging	0.08	damaging	3.39	23.00	deleterious	0.3	0.45	0.55	disease	0.63	disease	0.73	disease	0.72	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.52	medium_impact	1.78	medium_impact	0.33	0.8	47.49	9.46	0.46	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11399	11399	T	A	MI.17672	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	640	214	L	M	Tta/Ata	-1.35	0	0	probably_damaging	1	deleterious	0.03	neutral	4.53	neutral	-0.36	neutral	-1.53	medium_impact	2.9	0.37	damaging	0.1	damaging	3.72	23.30	deleterious	0.29	0.45	0.69	disease	0.58	disease	0.73	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.64	medium_impact	1.74	medium_impact	0.33	0.8	47.49	9.46	0.56	P	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11400	11400	T	G	MI.17673	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	641	214	L	W	tTa/tGa	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-3.75	deleterious	-4.62	high_impact	4.29	0.43	damaging	0.06	damaging	3.79	23.40	deleterious	0.06	0.35	0.88	disease	0.75	disease	0.78	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.12	high_impact	0.18	0.8	47.49	9.46	0.58	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11400	11400	T	C	MI.17674	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	641	214	L	S	tTa/tCa	-0.2	0	0	probably_damaging	1	neutral	0.06	neutral	4.5	neutral	-0.22	deleterious	-4.61	medium_impact	2.94	0.37	damaging	0.1	damaging	3.76	23.30	deleterious	0.05	0.35	0.35	neutral	0.76	disease	0.73	disease	0.74	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.47	medium_impact	1.78	medium_impact	0.15	0.8	47.49	9.46	0.54	P	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11401	11401	A	C	MI.17675	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	642	214	L	F	ttA/ttC	5.78	0.88	0	probably_damaging	1	deleterious	0.04	neutral	4.61	neutral	0.25	deleterious	-3.08	medium_impact	2.88	0.43	damaging	0.06	damaging	3.58	23.20	deleterious	0.25	0.45	0.74	disease	0.64	disease	0.74	disease	0.68	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.57	medium_impact	1.72	medium_impact	0.37	0.8	47.49	9.46	0.61	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11401	11401	A	T	MI.17676	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	642	214	L	F	ttA/ttT	5.78	0.88	0	probably_damaging	1	deleterious	0.04	neutral	4.61	neutral	0.25	deleterious	-3.08	medium_impact	2.88	0.43	damaging	0.06	damaging	3.59	23.20	deleterious	0.25	0.45	0.74	disease	0.64	disease	0.74	disease	0.68	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.57	medium_impact	1.72	medium_impact	0.37	0.8	47.49	9.46	0.61	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11402	11402	T	G	MI.17677	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	643	215	W	G	Tga/Gga	-6.88	0	0	probably_damaging	1	deleterious	0	neutral	0.43	deleterious	-11.95	deleterious	-10.01	high_impact	4.2	0.48	damaging	0.09	damaging	3.90	23.50	deleterious	0.03	0.35	0.54	disease	0.81	disease	0.83	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.06	0.8	47.28	9.32	0.43	N	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11402	11402	T	C	MI.17678	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	643	215	W	R	Tga/Cga	-6.88	0	0	probably_damaging	1	deleterious	0	neutral	0.43	deleterious	-12.85	deleterious	-10.78	high_impact	4.2	0.49	damaging	0.06	damaging	3.59	23.20	deleterious	0.02	0.35	0.34	neutral	0.89	disease	0.86	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.06	0.8	47.28	9.32	0.43	N	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11403	11403	G	C	MI.17679	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	644	215	W	S	tGa/tCa	5.78	1	0	probably_damaging	1	deleterious	0	neutral	0.43	deleterious	-12.98	deleterious	-10.78	high_impact	4.55	0.45	damaging	0.09	damaging	4.00	23.60	deleterious	0.03	0.35	0.31	neutral	0.88	disease	0.82	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.06	0.8	47.28	9.32	0.54	P	0.93	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8518	8518	A	C	MI.1768	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	153	51	W	C	tgA/tgC	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	1.46	deleterious	-9	deleterious	-12.14	high_impact	3.79	0.92	neutral	0.24	damaging	4.13	23.80	deleterious	0.24424793	0.85	0.94	disease	0.65	disease	0.76	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.06	medium_impact	2.15	high_impact	0.18	0.85	17.65	8.71	0.61	P	0.92	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11403	11403	G	T	MI.17680	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	644	215	W	L	tGa/tTa	5.78	1	0	probably_damaging	1	deleterious	0	neutral	0.43	deleterious	-11.93	deleterious	-10.01	high_impact	4.55	0.47	damaging	0.05	damaging	4.24	23.90	deleterious	0.03	0.35	0.53	disease	0.82	disease	0.82	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.05	0.8	47.28	9.32	0.58	P	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11404	11404	A	T	MI.17681	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	645	215	W	C	tgA/tgT	9.01	1	0	probably_damaging	1	deleterious	0	neutral	0.43	deleterious	-13.81	deleterious	-10.01	high_impact	4.55	0.44	damaging	0.04	damaging	4.13	23.80	deleterious	0.03	0.35	0.84	disease	0.85	disease	0.84	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.06	0.8	47.28	9.32	0.57	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11404	11404	A	C	MI.17682	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	645	215	W	C	tgA/tgC	9.01	1	0	probably_damaging	1	deleterious	0	neutral	0.43	deleterious	-13.81	deleterious	-10.01	high_impact	4.55	0.44	damaging	0.04	damaging	3.99	23.60	deleterious	0.03	0.35	0.84	disease	0.85	disease	0.84	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.06	0.8	47.28	9.32	0.57	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11405	11405	C	A	MI.17683	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	646	216	L	I	Ctc/Atc	5.55	1	0	probably_damaging	1	deleterious	0	neutral	4.1	deleterious	-4.54	neutral	-1.54	high_impact	4.54	0.43	damaging	0.09	damaging	4.08	23.70	deleterious	0.19	0.45	0.47	neutral	0.6	disease	0.72	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.51	0.8	46.62	9.3	0.73	P	0.87	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11405	11405	C	G	MI.17684	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	646	216	L	V	Ctc/Gtc	5.55	1	0	probably_damaging	1	deleterious	0	neutral	4.04	deleterious	-4.1	neutral	-2.31	high_impact	4.54	0.38	damaging	0.08	damaging	3.44	23.00	deleterious	0.15	0.45	0.47	neutral	0.57	disease	0.73	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.52	0.8	46.62	9.3	0.77	P	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11405	11405	C	T	MI.17685	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	646	216	L	F	Ctc/Ttc	5.55	1	0	probably_damaging	1	deleterious	0	neutral	4	deleterious	-5.92	deleterious	-3.08	high_impact	4.54	0.4	damaging	0.07	damaging	4.02	23.60	deleterious	0.1	0.4	0.38	neutral	0.63	disease	0.73	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.41	0.8	46.62	9.3	0.72	P	0.99	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11406	11406	T	C	MI.17686	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	647	216	L	P	cTc/cCc	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	3.93	deleterious	-7.44	deleterious	-5.38	high_impact	4.19	0.33	damaging	0.07	damaging	3.97	23.60	deleterious	0.02	0.35	0.81	disease	0.73	disease	0.72	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.02	high_impact	0.16	0.8	46.62	9.3	0.54	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11406	11406	T	G	MI.17687	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	647	216	L	R	cTc/cGc	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	3.93	deleterious	-6.83	deleterious	-4.61	high_impact	4.54	0.41	damaging	0.06	damaging	4.23	23.90	deleterious	0.01	0.35	0.73	disease	0.83	disease	0.82	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.15	0.8	46.62	9.3	0.61	P	1.00	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11406	11406	T	A	MI.17688	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	647	216	L	H	cTc/cAc	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	3.93	deleterious	-7.39	deleterious	-5.38	high_impact	4.54	0.4	damaging	0.06	damaging	4.34	24.00	deleterious	0.02	0.35	0.54	disease	0.75	disease	0.8	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.28	0.8	46.62	9.3	0.58	P	0.96	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11408	11408	C	T	MI.17689	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	649	217	P	S	Cct/Tct	-12.63	0	0	probably_damaging	0.98	deleterious	0	neutral	4.1	deleterious	-5.35	deleterious	-6.12	high_impact	4.17	0.63	neutral	0.57	neutral	3.93	23.50	deleterious	0.05	0.35	0.37	neutral	0.8	disease	0.71	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.31	low_impact	-1.48	low_impact	3	high_impact	0.06	0.8	46.62	9.41	0.44	N	0.71	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8519	8519	G	A	MI.1769	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	154	52	E	K	Gaa/Aaa	8.69	1	0	probably_damaging	0.97	neutral	0.92	neutral	1.84	neutral	-2.3	deleterious	-3.08	medium_impact	2.19	1	neutral	0.68	neutral	4.52	24.30	deleterious	0.61315205	0.85	0.6	disease	0.54	disease	0.45	neutral	0.45	neutral	1	0.97	neutral	0.48	deleterious	1	deleterious	0.80	deleterious	-2.19	low_impact	0.89	medium_impact	0.78	medium_impact	0.75	0.85	NA	NA	0.53	N	0.71	disease_causing	0.94	0.12	rs878853091	Likely_benign	not_provided	237351	MedGen:CN517202	.	.	.	1.93	G8519A	Susceptibility to bullous pemphigoid	+	-	Reported	1	N	P	N,P	neutral
chrM	11408	11408	C	A	MI.17690	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	649	217	P	T	Cct/Act	-12.63	0	0	probably_damaging	0.97	deleterious	0.02	neutral	4.14	deleterious	-5.45	deleterious	-6.13	high_impact	3.62	0.63	neutral	0.46	neutral	3.75	23.30	deleterious	0.05	0.35	0.57	disease	0.81	disease	0.73	disease	0.76	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.82	deleterious	-2.14	low_impact	-0.75	medium_impact	2.46	high_impact	0.35	0.8	46.62	9.41	0.35	N	0.89	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11408	11408	C	G	MI.17691	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	649	217	P	A	Cct/Gct	-12.63	0	0	possibly_damaging	0.89	deleterious	0	neutral	4.16	deleterious	-4.58	deleterious	-6.13	high_impact	4.17	0.59	damaging	0.53	neutral	3.11	22.50	deleterious	0.08	0.35	0.51	disease	0.67	disease	0.72	disease	0.71	disease	4	1	deleterious	0.06	neutral	5	deleterious	0.79	deleterious	-1.57	low_impact	-1.48	low_impact	3	high_impact	0.53	0.8	46.62	9.41	0.45	N	0.77	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11409	11409	C	A	MI.17692	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	650	217	P	H	cCt/cAt	4.4	0.99	0	probably_damaging	0.99	deleterious	0	neutral	4.08	deleterious	-6.78	deleterious	-6.9	high_impact	4.17	0.57	damaging	0.39	neutral	3.98	23.60	deleterious	0.04	0.35	0.37	neutral	0.84	disease	0.81	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.59	low_impact	-1.48	low_impact	3	high_impact	0.17	0.8	46.62	9.41	0.54	P	0.70	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11409	11409	C	G	MI.17693	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	650	217	P	R	cCt/cGt	4.4	0.99	0	probably_damaging	0.98	deleterious	0	neutral	4.09	deleterious	-5.91	deleterious	-6.9	high_impact	4.17	0.63	neutral	0.45	neutral	3.64	23.20	deleterious	0.03	0.35	0.59	disease	0.87	disease	0.82	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.31	low_impact	-1.48	low_impact	3	high_impact	0.16	0.8	46.62	9.41	0.6	P	0.58	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11409	11409	C	T	MI.17694	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	650	217	P	L	cCt/cTt	4.4	0.99	0	benign	0.29	deleterious	0.02	neutral	4.22	deleterious	-4.7	deleterious	-7.67	medium_impact	3.21	0.5	damaging	0.48	neutral	4.35	24.10	deleterious	0.03	0.35	0.7	disease	0.86	disease	0.71	disease	0.77	disease	5	0.98	neutral	0.37	neutral	1	deleterious	0.85	deleterious	-0.35	medium_impact	-0.75	medium_impact	2.05	high_impact	0.61	0.8	46.62	9.41	0.57	P	0.97	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11411	11411	A	G	MI.17695	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	652	218	K	E	Aaa/Gaa	-20	0	0	probably_damaging	1	deleterious	0	neutral	4.56	neutral	0	deleterious	-3.04	medium_impact	2.78	0.61	neutral	0.18	damaging	4.04	23.70	deleterious	0.18	0.45	0.46	neutral	0.86	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	1.62	medium_impact	0.43	0.8	47.28	9.23	0.33	N	0.87	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11411	11411	A	C	MI.17696	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	652	218	K	Q	Aaa/Caa	-20	0	0	probably_damaging	1	neutral	0.05	neutral	4.48	neutral	-0.85	deleterious	-3.04	medium_impact	3.5	0.62	neutral	0.17	damaging	3.42	23.00	deleterious	0.38	0.5	0.51	disease	0.82	disease	0.64	disease	0.7	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.52	medium_impact	2.34	high_impact	0.30	0.8	47.28	9.23	0.33	N	0.86	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11412	11412	A	T	MI.17697	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	653	218	K	M	aAa/aTa	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.41	neutral	-2.96	deleterious	-4.56	high_impact	3.84	0.66	neutral	0.17	damaging	4.01	23.60	deleterious	0.08	0.35	0.41	neutral	0.83	disease	0.57	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	2.67	high_impact	0.22	0.8	47.28	9.23	0.56	P	0.42	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11412	11412	A	C	MI.17698	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	653	218	K	T	aAa/aCa	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.5	neutral	-0.78	deleterious	-4.56	high_impact	3.58	0.62	neutral	0.17	damaging	3.71	23.30	deleterious	0.07	0.35	0.42	neutral	0.84	disease	0.64	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.42	high_impact	0.20	0.8	47.28	9.23	0.58	P	0.77	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11413	11413	A	T	MI.17699	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	654	218	K	N	aaA/aaT	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.45	neutral	-0.54	deleterious	-3.8	high_impact	4.04	0.61	neutral	0.15	damaging	3.96	23.60	deleterious	0.46	0.55	0.54	disease	0.83	disease	0.66	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.32	0.8	47.28	9.23	0.61	P	0.72	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8608	8608	C	A	MI.177	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	82	28	P	T	Cct/Act	-10.98	0	0	benign	0.38	neutral	0.17	neutral	4.47	neutral	2.5	neutral	1.35	neutral_impact	-0.5	0.91	neutral	0.95	neutral	0.04	3.01	deleterious	0.38	0.65	0.43	neutral	0.1	neutral	0.12	neutral	0.32	neutral	4	0.8	neutral	0.4	neutral	-6	neutral	0.33	neutral	-0.55	medium_impact	-0.1	medium_impact	-1.53	low_impact	0.77	0.9	31.86	20.94	0.53	P	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8519	8519	G	C	MI.1770	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	154	52	E	Q	Gaa/Caa	8.69	1	0	probably_damaging	0.98	neutral	0.57	neutral	1.81	neutral	-2.23	neutral	-1.93	medium_impact	2.09	0.99	neutral	0.7	neutral	1.77	14.80	neutral	0.62290357	0.85	0.64	disease	0.12	neutral	0.4	neutral	0.06	neutral	9	0.98	deleterious	0.3	neutral	1	deleterious	0.71	deleterious	-2.36	low_impact	0.36	medium_impact	0.69	medium_impact	0.75	0.85	NA	NA	0.61	P	0.11	disease_causing	0.77	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11413	11413	A	C	MI.17700	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	654	218	K	N	aaA/aaC	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.45	neutral	-0.54	deleterious	-3.8	high_impact	4.04	0.61	neutral	0.15	damaging	3.87	23.50	deleterious	0.46	0.55	0.54	disease	0.83	disease	0.66	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.32	0.8	47.28	9.23	0.6	P	0.72	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11414	11414	G	C	MI.17701	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	655	219	A	P	Gcc/Ccc	1.64	1	0	probably_damaging	1	deleterious	0	neutral	4.02	deleterious	-6.84	deleterious	-3.8	high_impact	4.52	0.44	damaging	0.06	damaging	3.88	23.50	deleterious	0.02	0.35	0.69	disease	0.83	disease	0.81	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.35	high_impact	0.31	0.8	46.84	9.32	0.66	P	0.96	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11414	11414	G	T	MI.17702	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	655	219	A	S	Gcc/Tcc	1.64	1	0	probably_damaging	1	deleterious	0	neutral	4.23	deleterious	-4.1	neutral	-2.27	high_impact	4.52	0.46	damaging	0.08	damaging	3.73	23.30	deleterious	0.06	0.35	0.46	neutral	0.78	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.35	high_impact	0.34	0.8	46.84	9.32	0.61	P	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11414	11414	G	A	MI.17703	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	655	219	A	T	Gcc/Acc	1.64	1	0	probably_damaging	1	deleterious	0	neutral	4.12	deleterious	-4.01	deleterious	-3.03	medium_impact	3.37	0.5	damaging	0.06	damaging	4.37	24.10	deleterious	0.05	0.35	0.44	neutral	0.8	disease	0.69	disease	0.71	disease	4	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.21	high_impact	0.59	0.8	46.84	9.32	0.49	P	0.82	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11415	11415	C	G	MI.17704	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	656	219	A	G	gCc/gGc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.03	deleterious	-5.5	deleterious	-3.04	high_impact	3.62	0.47	damaging	0.08	damaging	4.05	23.70	deleterious	0.06	0.35	0.62	disease	0.7	disease	0.69	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	2.46	high_impact	0.52	0.8	46.84	9.32	0.61	P	0.79	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11415	11415	C	T	MI.17705	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	656	219	A	V	gCc/gTc	7.4	1	0	probably_damaging	1	neutral	0.08	neutral	4.37	neutral	-2.78	deleterious	-3.04	medium_impact	3.1	0.45	damaging	0.06	damaging	4.48	24.20	deleterious	0.04	0.35	0.36	neutral	0.82	disease	0.68	disease	0.72	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.39	medium_impact	1.94	medium_impact	0.70	0.85	46.84	9.32	0.63	P	0.72	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11415	11415	C	A	MI.17706	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	656	219	A	D	gCc/gAc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.01	deleterious	-7.1	deleterious	-4.55	high_impact	4.52	0.45	damaging	0.05	damaging	4.70	24.60	deleterious	0.01	0.35	0.64	disease	0.9	disease	0.79	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.35	high_impact	0.27	0.8	46.84	9.32	0.62	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11417	11417	C	A	MI.17707	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	658	220	H	N	Cat/Aat	-3.89	0	0	possibly_damaging	0.64	deleterious	0	neutral	4.45	deleterious	-4.68	deleterious	-5.3	high_impact	4.53	0.56	damaging	0.43	neutral	4.06	23.70	deleterious	0.19	0.45	0.62	disease	0.8	disease	0.77	disease	0.77	disease	5	1	deleterious	0.18	neutral	5	deleterious	0.82	deleterious	-0.95	medium_impact	-1.48	low_impact	3.36	high_impact	0.16	0.8	46.84	9.26	0.53	N	0.97	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11417	11417	C	G	MI.17708	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	658	220	H	D	Cat/Gat	-3.89	0	0	benign	0.05	deleterious	0	neutral	4.44	deleterious	-5	deleterious	-6.82	high_impact	4.53	0.6	neutral	0.4	neutral	3.93	23.50	deleterious	0.06	0.35	0.64	disease	0.83	disease	0.8	disease	0.79	disease	6	1	deleterious	0.48	deleterious	2	deleterious	0.84	deleterious	0.48	medium_impact	-1.48	low_impact	3.36	high_impact	0.18	0.8	46.84	9.26	0.5	N	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11417	11417	C	T	MI.17709	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	658	220	H	Y	Cat/Tat	-3.89	0	0	possibly_damaging	0.89	deleterious	0	neutral	4.68	neutral	-0.32	deleterious	-4.55	medium_impact	3	0.61	neutral	0.33	neutral	3.80	23.40	deleterious	0.15	0.4	0.82	disease	0.85	disease	0.77	disease	0.82	disease	6	1	deleterious	0.06	neutral	4	deleterious	0.86	deleterious	-1.57	low_impact	-1.48	low_impact	1.84	medium_impact	0.15	0.8	46.84	9.26	0.35	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8520	8520	A	T	MI.1771	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	155	52	E	V	gAa/gTa	-0.1	0	0	probably_damaging	0.99	neutral	0.3	neutral	1.76	deleterious	-4.15	deleterious	-6.19	medium_impact	2.98	0.99	neutral	0.52	neutral	4.12	23.80	deleterious	0.34743468	0.85	0.79	disease	0.47	neutral	0.6	disease	0.32	neutral	4	0.99	deleterious	0.16	neutral	1	deleterious	0.83	deleterious	-2.65	low_impact	0.08	medium_impact	1.46	medium_impact	0.72	0.85	NA	NA	0.5	N	0.72	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11418	11418	A	T	MI.17710	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	659	220	H	L	cAt/cTt	7.17	1	0	possibly_damaging	0.82	deleterious	0	neutral	4.58	neutral	-2.84	deleterious	-8.34	high_impact	4.53	0.57	damaging	0.45	neutral	3.95	23.60	deleterious	0.05	0.35	0.67	disease	0.86	disease	0.77	disease	0.78	disease	6	1	deleterious	0.09	neutral	5	deleterious	0.85	deleterious	-1.34	low_impact	-1.48	low_impact	3.36	high_impact	0.06	0.8	46.84	9.26	0.69	P	0.96	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11418	11418	A	G	MI.17711	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	659	220	H	R	cAt/cGt	7.17	1	0	possibly_damaging	0.76	deleterious	0	neutral	4.46	deleterious	-4.43	deleterious	-6.06	high_impact	4.53	0.62	neutral	0.32	neutral	3.10	22.50	deleterious	0.13	0.4	0.65	disease	0.83	disease	0.76	disease	0.79	disease	6	1	deleterious	0.12	neutral	5	deleterious	0.87	deleterious	-1.19	low_impact	-1.48	low_impact	3.36	high_impact	0.38	0.8	46.84	9.26	0.62	P	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11418	11418	A	C	MI.17712	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	659	220	H	P	cAt/cCt	7.17	1	0	probably_damaging	0.93	deleterious	0	neutral	4.45	deleterious	-5.24	deleterious	-7.58	high_impact	4.53	0.6	neutral	0.38	neutral	3.43	23.00	deleterious	0.06	0.35	0.72	disease	0.85	disease	0.78	disease	0.79	disease	6	1	deleterious	0.04	neutral	6	deleterious	0.88	deleterious	-1.77	low_impact	-1.48	low_impact	3.36	high_impact	0.07	0.8	46.84	9.26	0.63	P	0.95	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11419	11419	T	G	MI.17713	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	660	220	H	Q	caT/caG	8.55	1	0	benign	0.13	deleterious	0	neutral	4.45	deleterious	-4.41	deleterious	-6.06	high_impact	4.53	0.55	damaging	0.41	neutral	3.62	23.20	deleterious	0.12	0.4	0.64	disease	0.8	disease	0.77	disease	0.77	disease	5	1	deleterious	0.44	neutral	2	deleterious	0.83	deleterious	0.06	medium_impact	-1.48	low_impact	3.36	high_impact	0.23	0.8	46.84	9.26	0.63	P	0.93	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11419	11419	T	A	MI.17714	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	660	220	H	Q	caT/caA	8.55	1	0	benign	0.13	deleterious	0	neutral	4.45	deleterious	-4.41	deleterious	-6.06	high_impact	4.53	0.55	damaging	0.41	neutral	3.84	23.40	deleterious	0.12	0.4	0.64	disease	0.8	disease	0.77	disease	0.77	disease	5	1	deleterious	0.44	neutral	2	deleterious	0.83	deleterious	0.06	medium_impact	-1.48	low_impact	3.36	high_impact	0.23	0.8	46.84	9.26	0.64	P	0.93	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11420	11420	G	T	MI.17715	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	661	221	V	F	Gtc/Ttc	-4.35	0	0	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-3.72	deleterious	-3.79	high_impact	4.49	0.52	damaging	0.08	damaging	3.83	23.40	deleterious	0.1	0.4	0.65	disease	0.88	disease	0.63	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.32	high_impact	0.20	0.8	47.06	9.31	0.41	N	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11420	11420	G	A	MI.17716	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	661	221	V	I	Gtc/Atc	-4.35	0	0	probably_damaging	1	deleterious	0	neutral	4.5	neutral	-1.6	neutral	-0.76	high_impact	4.13	0.53	damaging	0.09	damaging	3.70	23.30	deleterious	0.33	0.5	0.28	neutral	0.62	disease	0.48	neutral	0.5	disease	0	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.54	low_impact	-1.48	low_impact	2.96	high_impact	0.68	0.85	47.06	9.31	0.43	N	0.44	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11420	11420	G	C	MI.17717	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	661	221	V	L	Gtc/Ctc	-4.35	0	0	probably_damaging	1	deleterious	0.01	neutral	4.47	neutral	-2.28	neutral	-2.27	high_impact	3.68	0.49	damaging	0.07	damaging	3.57	23.10	deleterious	0.21	0.45	0.42	neutral	0.7	disease	0.58	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-0.92	medium_impact	2.52	high_impact	0.42	0.8	47.06	9.31	0.35	N	0.74	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11421	11421	T	C	MI.17718	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	662	221	V	A	gTc/gCc	6.01	1	0	probably_damaging	1	neutral	0.05	neutral	4.54	neutral	-0.96	deleterious	-3.03	medium_impact	3.06	0.49	damaging	0.12	damaging	3.56	23.10	deleterious	0.3	0.45	0.54	disease	0.62	disease	0.59	disease	0.66	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.52	medium_impact	1.9	medium_impact	0.20	0.8	47.06	9.31	0.66	P	0.54	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11421	11421	T	A	MI.17719	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	662	221	V	D	gTc/gAc	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.47	neutral	-2.22	deleterious	-5.3	high_impact	4.13	0.51	damaging	0.08	damaging	4.42	24.20	deleterious	0.05	0.35	0.86	disease	0.88	disease	0.68	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	2.96	high_impact	0.02	0.8	47.06	9.31	0.62	P	0.95	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8520	8520	A	G	MI.1772	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	155	52	E	G	gAa/gGa	-0.1	0	0	probably_damaging	0.98	neutral	0.38	neutral	1.77	deleterious	-3.69	deleterious	-5.97	medium_impact	3.33	0.99	neutral	0.67	neutral	4.25	23.90	deleterious	0.49682067	0.85	0.56	disease	0.4	neutral	0.57	disease	0.25	neutral	5	0.98	deleterious	0.2	neutral	1	deleterious	0.77	deleterious	-2.36	low_impact	0.17	medium_impact	1.76	medium_impact	0.46	0.85	NA	NA	0.51	N	0.42	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11421	11421	T	G	MI.17720	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	662	221	V	G	gTc/gGc	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.48	neutral	-2.14	deleterious	-5.3	high_impact	3.51	0.5	damaging	0.1	damaging	3.82	23.40	deleterious	0.07	0.35	0.77	disease	0.77	disease	0.62	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.35	high_impact	0.18	0.8	47.06	9.31	0.56	P	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11423	11423	G	C	MI.17721	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	664	222	E	Q	Gaa/Caa	-2.73	0	0	probably_damaging	0.95	deleterious	0	neutral	4.48	neutral	-2.47	neutral	-2.27	medium_impact	2.83	0.44	damaging	0.61	neutral	3.33	22.90	deleterious	0.51	0.6	0.71	disease	0.77	disease	0.69	disease	0.71	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.84	deleterious	-1.92	low_impact	-1.48	low_impact	1.67	medium_impact	0.33	0.8	47.49	9.45	0.48	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11423	11423	G	A	MI.17722	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	664	222	E	K	Gaa/Aaa	-2.73	0	0	possibly_damaging	0.85	deleterious	0	neutral	4.51	neutral	-2.63	deleterious	-3.02	high_impact	3.91	0.46	damaging	0.43	neutral	4.51	24.30	deleterious	0.15	0.4	0.65	disease	0.87	disease	0.75	disease	0.79	disease	6	1	deleterious	0.08	neutral	5	deleterious	0.87	deleterious	-1.43	low_impact	-1.48	low_impact	2.74	high_impact	0.69	0.85	47.49	9.45	0.57	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11424	11424	A	T	MI.17723	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	665	222	E	V	gAa/gTa	6.01	1	0	probably_damaging	0.96	deleterious	0	neutral	4.42	deleterious	-3.59	deleterious	-5.29	high_impact	4.46	0.41	damaging	0.57	neutral	4.28	24.00	deleterious	0.12	0.4	0.53	disease	0.88	disease	0.71	disease	0.77	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-2.01	low_impact	-1.48	low_impact	3.29	high_impact	0.44	0.8	47.49	9.45	0.79	P	0.80	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11424	11424	A	G	MI.17724	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	665	222	E	G	gAa/gGa	6.01	1	0	benign	0.08	deleterious	0	neutral	4.71	neutral	-1.58	deleterious	-5.29	high_impact	3.56	0.4	damaging	0.68	neutral	4.27	23.90	deleterious	0.21	0.45	0.78	disease	0.76	disease	0.7	disease	0.73	disease	5	1	deleterious	0.46	neutral	2	deleterious	0.84	deleterious	0.28	medium_impact	-1.48	low_impact	2.4	high_impact	0.28	0.8	47.49	9.45	0.75	P	0.53	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11424	11424	A	C	MI.17725	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	665	222	E	A	gAa/gCa	6.01	1	0	possibly_damaging	0.74	deleterious	0	neutral	4.53	neutral	-1.28	deleterious	-4.53	high_impact	3.77	0.48	damaging	0.63	neutral	3.78	23.40	deleterious	0.16	0.45	0.59	disease	0.74	disease	0.68	disease	0.69	disease	4	1	deleterious	0.13	neutral	5	deleterious	0.82	deleterious	-1.14	low_impact	-1.48	low_impact	2.6	high_impact	0.38	0.8	47.49	9.45	0.7	P	0.74	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11425	11425	A	T	MI.17726	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	666	222	E	D	gaA/gaT	8.55	1	0	possibly_damaging	0.85	deleterious	0.01	neutral	4.45	deleterious	-3.45	neutral	-2.27	medium_impact	3.04	0.53	damaging	0.58	neutral	3.88	23.50	deleterious	0.39	0.5	0.76	disease	0.76	disease	0.66	disease	0.71	disease	4	0.99	deleterious	0.08	neutral	4	deleterious	0.83	deleterious	-1.43	low_impact	-0.92	medium_impact	1.88	medium_impact	0.25	0.8	47.49	9.45	0.65	P	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11425	11425	A	C	MI.17727	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	666	222	E	D	gaA/gaC	8.55	1	0	possibly_damaging	0.85	deleterious	0.01	neutral	4.45	deleterious	-3.45	neutral	-2.27	medium_impact	3.04	0.53	damaging	0.58	neutral	3.75	23.30	deleterious	0.39	0.5	0.76	disease	0.76	disease	0.66	disease	0.71	disease	4	0.99	deleterious	0.08	neutral	4	deleterious	0.83	deleterious	-1.43	low_impact	-0.92	medium_impact	1.88	medium_impact	0.25	0.8	47.49	9.45	0.64	P	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11426	11426	G	T	MI.17728	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	667	223	A	S	Gcc/Tcc	-0.2	0.62	0	possibly_damaging	0.86	deleterious	0.03	neutral	4.52	deleterious	-3.54	neutral	-2.27	medium_impact	2.83	0.64	neutral	0.58	neutral	3.71	23.30	deleterious	0.08	0.35	0.78	disease	0.79	disease	0.67	disease	0.72	disease	4	0.98	deleterious	0.09	neutral	4	deleterious	0.87	deleterious	-1.46	low_impact	-0.64	medium_impact	1.67	medium_impact	0.37	0.8	47.06	9.1	0.39	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11426	11426	G	A	MI.17729	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	667	223	A	T	Gcc/Acc	-0.2	0.62	0	probably_damaging	0.95	deleterious	0	neutral	4.43	deleterious	-4.45	deleterious	-3.03	high_impact	4.51	0.54	damaging	0.49	neutral	4.33	24.00	deleterious	0.05	0.35	0.81	disease	0.78	disease	0.68	disease	0.74	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.88	deleterious	-1.92	low_impact	-1.48	low_impact	3.34	high_impact	0.60	0.8	47.06	9.1	0.5	N	0.82	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8520	8520	A	C	MI.1773	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	155	52	E	A	gAa/gCa	-0.1	0	0	probably_damaging	0.97	neutral	0.73	neutral	1.8	neutral	-2.9	deleterious	-5.17	medium_impact	2.36	0.98	neutral	0.54	neutral	3.64	23.20	deleterious	0.56962521	0.85	0.62	disease	0.36	neutral	0.57	disease	0.25	neutral	5	0.97	neutral	0.38	neutral	1	deleterious	0.77	deleterious	-2.19	low_impact	0.54	medium_impact	0.93	medium_impact	0.70	0.85	NA	NA	0.35	N	0.58	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11426	11426	G	C	MI.17730	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	667	223	A	P	Gcc/Ccc	-0.2	0.62	0	probably_damaging	0.99	deleterious	0	neutral	4.61	deleterious	-3.36	deleterious	-3.79	high_impact	4.51	0.62	neutral	0.43	neutral	3.87	23.50	deleterious	0.03	0.35	0.91	disease	0.83	disease	0.66	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.59	low_impact	-1.48	low_impact	3.34	high_impact	0.51	0.8	47.06	9.1	0.45	N	0.96	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11427	11427	C	A	MI.17731	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	668	223	A	D	gCc/gAc	9.01	1	0	probably_damaging	0.98	deleterious	0	neutral	4.39	deleterious	-6.65	deleterious	-4.54	high_impact	4.51	0.68	neutral	0.44	neutral	4.67	24.50	deleterious	0.02	0.35	0.93	disease	0.9	disease	0.79	disease	0.89	disease	8	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.31	low_impact	-1.48	low_impact	3.34	high_impact	0.28	0.8	47.06	9.1	0.66	P	0.98	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11427	11427	C	G	MI.17732	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	668	223	A	G	gCc/gGc	9.01	1	0	benign	0.15	deleterious	0	neutral	4.39	neutral	-2.28	deleterious	-3.02	high_impact	3.82	0.52	damaging	0.6	neutral	4.01	23.60	deleterious	0.09	0.35	0.85	disease	0.72	disease	0.58	disease	0.72	disease	4	1	deleterious	0.43	neutral	2	deleterious	0.84	deleterious	-0.01	medium_impact	-1.48	low_impact	2.65	high_impact	0.66	0.8	47.06	9.1	0.6	P	0.79	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11427	11427	C	T	MI.17733	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	668	223	A	V	gCc/gTc	9.01	1	0	probably_damaging	0.96	deleterious	0	neutral	4.46	deleterious	-6.03	deleterious	-3.03	high_impact	4.17	0.53	damaging	0.48	neutral	4.46	24.20	deleterious	0.04	0.35	0.79	disease	0.81	disease	0.71	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.01	low_impact	-1.48	low_impact	3	high_impact	0.65	0.8	47.06	9.1	0.61	P	0.72	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11429	11429	C	G	MI.17734	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	670	224	P	A	Ccc/Gcc	-7.34	0	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-4.5	deleterious	-6.47	high_impact	4.51	0.47	damaging	0.11	damaging	3.12	22.60	deleterious	0.1	0.4	0.24	neutral	0.68	disease	0.72	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	3.34	high_impact	0.39	0.8	46.84	9.25	0.45	N	0.77	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11429	11429	C	T	MI.17735	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	670	224	P	S	Ccc/Tcc	-7.34	0	0	probably_damaging	1	neutral	0.06	neutral	4.51	deleterious	-3.87	deleterious	-6.47	medium_impact	2.82	0.48	damaging	0.09	damaging	3.93	23.50	deleterious	0.1	0.4	0.25	neutral	0.83	disease	0.68	disease	0.73	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.47	medium_impact	1.66	medium_impact	0.14	0.8	46.84	9.25	0.32	N	0.71	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11429	11429	C	A	MI.17736	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	670	224	P	T	Ccc/Acc	-7.34	0	0	probably_damaging	1	deleterious	0.01	neutral	4.6	deleterious	-3.08	deleterious	-6.47	high_impact	3.62	0.52	damaging	0.08	damaging	3.73	23.30	deleterious	0.09	0.35	0.23	neutral	0.79	disease	0.67	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	2.46	high_impact	0.37	0.8	46.84	9.25	0.29	N	0.89	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11430	11430	C	T	MI.17737	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	671	224	P	L	cCc/cTc	4.4	0.99	0	probably_damaging	1	deleterious	0	neutral	4.4	deleterious	-5.16	deleterious	-8.09	high_impact	4.51	0.45	damaging	0.06	damaging	4.43	24.20	deleterious	0.05	0.35	0.27	neutral	0.85	disease	0.69	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.34	high_impact	0.46	0.8	46.84	9.25	0.56	P	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11430	11430	C	G	MI.17738	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	671	224	P	R	cCc/cGc	4.4	0.99	0	probably_damaging	1	deleterious	0	neutral	4.4	deleterious	-5	deleterious	-7.28	high_impact	4.51	0.56	damaging	0.07	damaging	3.62	23.20	deleterious	0.04	0.35	0.51	disease	0.88	disease	0.8	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.34	high_impact	0.22	0.8	46.84	9.25	0.62	P	0.58	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11430	11430	C	A	MI.17739	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	671	224	P	H	cCc/cAc	4.4	0.99	0	probably_damaging	1	deleterious	0	neutral	4.4	deleterious	-5.68	deleterious	-7.28	high_impact	3.62	0.49	damaging	0.06	damaging	4.05	23.70	deleterious	0.06	0.35	0.63	disease	0.83	disease	0.81	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.46	high_impact	0.23	0.8	46.84	9.25	0.55	P	0.70	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8521	8521	A	T	MI.1774	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	156	52	E	D	gaA/gaT	0.82	0	0.01	probably_damaging	0.97	neutral	0.61	neutral	1.81	neutral	-2.41	deleterious	-2.61	medium_impact	2.23	1	neutral	0.57	neutral	3.78	23.40	deleterious	0.63950197	0.85	0.45	neutral	0.35	neutral	0.37	neutral	0.18	neutral	6	0.97	neutral	0.32	neutral	1	deleterious	0.73	deleterious	-2.19	low_impact	0.4	medium_impact	0.81	medium_impact	0.81	0.85	NA	NA	0.4	N	0.62	polymorphism	1	0.12	rs386829038	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11432	11432	A	G	MI.17740	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	673	225	I	V	Atc/Gtc	-13.55	0	0	probably_damaging	1	neutral	0.99	neutral	4.68	neutral	0.7	neutral	-0.61	low_impact	1.26	0.62	neutral	0.66	neutral	1.58	13.73	neutral	0.34	0.5	0.45	neutral	0.14	neutral	0.47	neutral	0.28	neutral	4	1	deleterious	0.5	deleterious	-2	neutral	0.64	deleterious	-3.54	low_impact	1.32	medium_impact	0.12	medium_impact	0.20	0.8	48.58	9.21	0.31	N	0.75	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11432	11432	A	T	MI.17741	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	673	225	I	F	Atc/Ttc	-13.55	0	0	probably_damaging	1	deleterious	0.04	neutral	4.62	neutral	-1.54	deleterious	-3.2	medium_impact	3.26	0.7	neutral	0.43	neutral	3.90	23.50	deleterious	0.13	0.4	0.68	disease	0.81	disease	0.73	disease	0.75	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-3.54	low_impact	-0.57	medium_impact	2.1	high_impact	0.23	0.8	48.58	9.21	0.38	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11432	11432	A	C	MI.17742	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	673	225	I	L	Atc/Ctc	-13.55	0	0	probably_damaging	1	neutral	0.13	neutral	4.71	neutral	0.24	neutral	-1.6	medium_impact	1.99	0.73	neutral	0.46	neutral	3.83	23.40	deleterious	0.2	0.45	0.41	neutral	0.63	disease	0.68	disease	0.67	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.69	deleterious	-3.54	low_impact	-0.26	medium_impact	0.84	medium_impact	0.30	0.8	48.58	9.21	0.43	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11433	11433	T	G	MI.17743	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	674	225	I	S	aTc/aGc	3.94	0.99	0	probably_damaging	1	neutral	0.07	neutral	4.59	neutral	1.62	deleterious	-4.67	medium_impact	2.71	0.76	neutral	0.52	neutral	4.32	24.00	deleterious	0.05	0.35	0.48	neutral	0.87	disease	0.71	disease	0.77	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.43	medium_impact	1.56	medium_impact	0.15	0.8	48.58	9.21	0.52	P	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11433	11433	T	A	MI.17744	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	674	225	I	N	aTc/aAc	3.94	0.99	0	probably_damaging	1	deleterious	0	neutral	4.56	neutral	-0.86	deleterious	-5.48	high_impact	3.6	0.7	neutral	0.44	neutral	4.46	24.20	deleterious	0.09	0.35	0.77	disease	0.84	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.44	high_impact	0.08	0.8	48.58	9.21	0.54	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11433	11433	T	C	MI.17745	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	674	225	I	T	aTc/aCc	3.94	0.99	0	probably_damaging	1	neutral	0.23	neutral	4.75	neutral	3.36	deleterious	-3.79	low_impact	1.62	0.71	neutral	0.46	neutral	3.45	23.00	deleterious	0.12	0.4	0.33	neutral	0.72	disease	0.7	disease	0.71	disease	4	1	deleterious	0.12	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	-0.09	medium_impact	0.48	medium_impact	0.12	0.8	48.58	9.21	0.51	P	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11434	11434	C	G	MI.17746	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	675	225	I	M	atC/atG	5.78	1	0	probably_damaging	1	deleterious	0.03	neutral	4.59	neutral	-1.37	neutral	-2.3	high_impact	3.6	0.72	neutral	0.52	neutral	3.38	23.00	deleterious	0.25	0.45	0.67	disease	0.66	disease	0.71	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-0.64	medium_impact	2.44	high_impact	0.21	0.8	48.58	9.21	0.65	P	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11434	11434	C	A	MI.17747	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	675	225	I	M	atC/atA	5.78	1	0	probably_damaging	1	deleterious	0.03	neutral	4.59	neutral	-1.37	neutral	-2.3	high_impact	3.6	0.72	neutral	0.52	neutral	3.88	23.50	deleterious	0.25	0.45	0.67	disease	0.66	disease	0.71	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-0.64	medium_impact	2.44	high_impact	0.21	0.8	48.58	9.21	0.65	P	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11435	11435	G	A	MI.17748	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	676	226	A	T	Gct/Act	-2.96	0	0	probably_damaging	1	neutral	0.12	neutral	4.61	neutral	-1.79	deleterious	-3.23	medium_impact	3.02	0.44	damaging	0.06	damaging	4.21	23.90	deleterious	0.21	0.45	0.48	neutral	0.81	disease	0.72	disease	0.74	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	-0.28	medium_impact	1.86	medium_impact	0.64	0.8	47.06	9.45	0.43	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11435	11435	G	C	MI.17749	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	676	226	A	P	Gct/Cct	-2.96	0	0	probably_damaging	1	deleterious	0.01	neutral	4.59	neutral	1.17	deleterious	-4.04	medium_impact	2.5	0.47	damaging	0.06	damaging	3.80	23.40	deleterious	0.1	0.4	0.74	disease	0.88	disease	0.81	disease	0.82	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.89	deleterious	-3.54	low_impact	-0.92	medium_impact	1.35	medium_impact	0.49	0.8	47.06	9.45	0.39	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8521	8521	A	C	MI.1775	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	156	52	E	D	gaA/gaC	0.82	0	0.01	probably_damaging	0.97	neutral	0.61	neutral	1.81	neutral	-2.41	deleterious	-2.61	medium_impact	2.23	1	neutral	0.57	neutral	3.68	23.30	deleterious	0.63950197	0.85	0.45	neutral	0.35	neutral	0.37	neutral	0.18	neutral	6	0.97	neutral	0.32	neutral	1	deleterious	0.73	deleterious	-2.19	low_impact	0.4	medium_impact	0.81	medium_impact	0.81	0.85	NA	NA	0.39	N	0.62	polymorphism	1	0.12	rs386829038	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11435	11435	G	T	MI.17750	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	676	226	A	S	Gct/Tct	-2.96	0	0	probably_damaging	1	neutral	0.38	neutral	4.65	neutral	-1.02	neutral	-2.42	low_impact	1.74	0.5	damaging	0.09	damaging	3.70	23.30	deleterious	0.29	0.45	0.52	disease	0.71	disease	0.65	disease	0.52	disease	0	1	deleterious	0.19	neutral	-2	neutral	0.81	deleterious	-3.54	low_impact	0.08	medium_impact	0.6	medium_impact	0.40	0.8	47.06	9.45	0.27	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11436	11436	C	G	MI.17751	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	677	226	A	G	gCt/gGt	7.17	1	0	probably_damaging	1	neutral	0.07	neutral	4.58	neutral	-2.02	deleterious	-3.23	medium_impact	2.35	0.5	damaging	0.09	damaging	4.02	23.60	deleterious	0.28	0.45	0.67	disease	0.79	disease	0.71	disease	0.73	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.43	medium_impact	1.2	medium_impact	0.50	0.8	47.06	9.45	0.59	P	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11436	11436	C	T	MI.17752	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	677	226	A	V	gCt/gTt	7.17	1	0	probably_damaging	1	deleterious	0.01	neutral	4.8	neutral	-0.3	deleterious	-3.23	medium_impact	2.9	0.45	damaging	0.07	damaging	4.44	24.20	deleterious	0.16	0.45	0.27	neutral	0.86	disease	0.7	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-0.92	medium_impact	1.74	medium_impact	0.62	0.8	47.06	9.45	0.6	P	0.72	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11436	11436	C	A	MI.17753	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	677	226	A	D	gCt/gAt	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.54	deleterious	-3.05	deleterious	-4.84	high_impact	4.21	0.49	damaging	0.05	damaging	4.49	24.30	deleterious	0.03	0.35	0.73	disease	0.92	disease	0.82	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.04	high_impact	0.21	0.8	47.06	9.45	0.66	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11438	11438	G	C	MI.17754	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	679	227	G	R	Ggg/Cgg	-15.4	0	0	probably_damaging	1	deleterious	0	neutral	4.55	deleterious	-3.3	deleterious	-6.5	high_impact	4.2	0.55	damaging	0.12	damaging	4.02	23.60	deleterious	0.02	0.35	0.57	disease	0.91	disease	0.83	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.53	0.8	46.84	9.36	0.42	N	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11438	11438	G	T	MI.17755	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	679	227	G	W	Ggg/Tgg	-15.4	0	0	probably_damaging	1	deleterious	0	neutral	4.51	deleterious	-4.73	deleterious	-6.5	high_impact	4.54	0.57	damaging	0.11	damaging	4.46	24.20	deleterious	0.04	0.35	0.9	disease	0.91	disease	0.78	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.19	0.8	46.84	9.36	0.48	N	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11439	11439	G	T	MI.17756	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	680	227	G	V	gGg/gTg	4.17	1	0	probably_damaging	1	deleterious	0.02	neutral	4.64	neutral	1.58	deleterious	-7.32	medium_impact	3.02	0.54	damaging	0.11	damaging	3.81	23.40	deleterious	0.04	0.35	0.53	disease	0.91	disease	0.75	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.87	deleterious	-3.54	low_impact	-0.75	medium_impact	1.86	medium_impact	0.12	0.8	46.84	9.36	0.48	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11439	11439	G	A	MI.17757	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	680	227	G	E	gGg/gAg	4.17	1	0	probably_damaging	1	deleterious	0	neutral	4.58	deleterious	-3.34	deleterious	-6.5	high_impact	4.2	0.56	damaging	0.12	damaging	3.89	23.50	deleterious	0.02	0.35	0.48	neutral	0.9	disease	0.82	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.17	0.8	46.84	9.36	0.62	P	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11439	11439	G	C	MI.17758	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	680	227	G	A	gGg/gCg	4.17	1	0	probably_damaging	1	neutral	0.07	neutral	4.6	neutral	-0.33	deleterious	-4.88	medium_impact	3.34	0.61	neutral	0.15	damaging	3.09	22.50	deleterious	0.16	0.45	0.29	neutral	0.75	disease	0.7	disease	0.7	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.43	medium_impact	2.18	high_impact	0.37	0.8	46.84	9.36	0.57	P	0.76	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11441	11441	T	G	MI.17759	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	682	228	S	A	Tca/Gca	-20	0	0	probably_damaging	1	deleterious	0	neutral	4.58	neutral	-0.59	neutral	-2.44	high_impact	3.56	0.48	damaging	0.15	damaging	3.73	23.30	deleterious	0.07	0.35	0.61	disease	0.63	disease	0.64	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	2.4	high_impact	0.40	0.8	47.93	9.62	0.39	N	0.51	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8522	8522	C	A	MI.1776	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	157	53	P	T	Cca/Aca	-0.33	0	0	benign	0.07	neutral	0.41	neutral	2.02	neutral	0.51	neutral	1.08	neutral_impact	-0.96	0.94	neutral	0.97	neutral	-0.15	1.38	neutral	0.37793802	0.85	0.17	neutral	0.16	neutral	0.19	neutral	0.14	neutral	7	0.54	neutral	0.67	deleterious	-6	neutral	0.12	neutral	0.31	medium_impact	0.2	medium_impact	-1.92	low_impact	0.67	0.85	NA	NA	0.39	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11441	11441	T	C	MI.17760	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	682	228	S	P	Tca/Cca	-20	0	0	probably_damaging	1	deleterious	0	neutral	4.28	deleterious	-5.65	deleterious	-4.07	high_impact	4.2	0.38	damaging	0.1	damaging	4.00	23.60	deleterious	0.02	0.35	0.85	disease	0.85	disease	0.8	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.38	0.8	47.93	9.62	0.52	P	0.99	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11441	11441	T	A	MI.17761	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	682	228	S	T	Tca/Aca	-20	0	0	probably_damaging	1	deleterious	0.01	neutral	4.39	neutral	-1.91	neutral	-2.44	medium_impact	3.5	0.46	damaging	0.1	damaging	3.82	23.40	deleterious	0.08	0.35	0.66	disease	0.71	disease	0.7	disease	0.69	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.92	medium_impact	2.34	high_impact	0.55	0.8	47.93	9.62	0.34	N	0.73	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11442	11442	C	G	MI.17762	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	683	228	S	W	tCa/tGa	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.27	deleterious	-6.88	deleterious	-5.7	high_impact	4.2	0.45	damaging	0.07	damaging	4.34	24.00	deleterious	0.02	0.35	0.84	disease	0.9	disease	0.74	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.19	0.8	47.93	9.62	0.62	P	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11442	11442	C	T	MI.17763	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	683	228	S	L	tCa/tTa	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.33	deleterious	-3.13	deleterious	-4.88	high_impact	3.85	0.44	damaging	0.05	damaging	4.69	24.60	deleterious	0.02	0.35	0.32	neutral	0.86	disease	0.67	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.54	low_impact	-1.48	low_impact	2.68	high_impact	0.41	0.8	47.93	9.62	0.64	P	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11444	11444	A	G	MI.17764	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	685	229	M	V	Ata/Gta	-14.01	0	0	probably_damaging	0.99	neutral	0.07	neutral	4.6	neutral	1.07	deleterious	-3.26	medium_impact	2.28	0.6	damaging	0.09	damaging	2.76	21.10	deleterious	0.13	0.4	0.32	neutral	0.85	disease	0.72	disease	0.76	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.68	deleterious	-2.59	low_impact	-0.43	medium_impact	1.13	medium_impact	0.36	0.8	47.06	9.46	0.25	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11444	11444	A	C	MI.17765	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	685	229	M	L	Ata/Cta	-14.01	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.92	neutral	1.86	neutral	-2.44	high_impact	3.58	0.63	neutral	0.06	damaging	3.28	22.80	deleterious	0.14	0.4	0.33	neutral	0.82	disease	0.68	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.60	deleterious	-2.31	low_impact	-0.92	medium_impact	2.42	high_impact	0.30	0.8	47.06	9.46	0.3	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11444	11444	A	T	MI.17766	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	685	229	M	L	Ata/Tta	-14.01	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.92	neutral	1.86	neutral	-2.44	high_impact	3.58	0.63	neutral	0.06	damaging	3.42	23.00	deleterious	0.14	0.4	0.33	neutral	0.82	disease	0.68	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.60	deleterious	-2.31	low_impact	-0.92	medium_impact	2.42	high_impact	0.30	0.8	47.06	9.46	0.31	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11445	11445	T	A	MI.17767	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	686	229	M	K	aTa/aAa	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.5	neutral	-2.77	deleterious	-4.89	high_impact	4.48	0.64	neutral	0.08	damaging	4.24	23.90	deleterious	0.02	0.35	0.58	disease	0.92	disease	0.78	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.31	high_impact	0.15	0.8	47.06	9.46	0.65	P	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11445	11445	T	C	MI.17768	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	686	229	M	T	aTa/aCa	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.55	neutral	-0.8	deleterious	-4.89	high_impact	4.48	0.74	neutral	0.1	damaging	3.01	22.30	deleterious	0.04	0.35	0.49	neutral	0.86	disease	0.71	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.31	high_impact	0.24	0.8	47.06	9.46	0.58	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11446	11446	A	T	MI.17769	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	687	229	M	I	atA/atT	7.4	1	0	probably_damaging	0.99	neutral	0.06	neutral	4.7	neutral	-0.06	deleterious	-3.26	medium_impact	2.75	0.67	neutral	0.16	damaging	3.53	23.10	deleterious	0.16	0.45	0.38	neutral	0.86	disease	0.71	disease	0.76	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-2.59	low_impact	-0.47	medium_impact	1.6	medium_impact	0.46	0.8	47.06	9.46	0.58	P	0.95	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8522	8522	C	G	MI.1777	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	157	53	P	A	Cca/Gca	-0.33	0	0	benign	0.03	neutral	0.5	neutral	2.01	neutral	0.33	neutral	0.22	neutral_impact	0.26	0.99	neutral	0.77	neutral	-1.26	0.01	neutral	0.43104827	0.85	0.16	neutral	0.1	neutral	0.29	neutral	0.06	neutral	9	0.47	neutral	0.74	deleterious	-6	neutral	0.13	neutral	0.68	medium_impact	0.29	medium_impact	-0.88	medium_impact	0.69	0.85	NA	NA	0.46	N	0.32	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11446	11446	A	C	MI.17770	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	687	229	M	I	atA/atC	7.4	1	0	probably_damaging	0.99	neutral	0.06	neutral	4.7	neutral	-0.06	deleterious	-3.26	medium_impact	2.75	0.67	neutral	0.16	damaging	3.30	22.90	deleterious	0.16	0.45	0.38	neutral	0.86	disease	0.71	disease	0.76	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-2.59	low_impact	-0.47	medium_impact	1.6	medium_impact	0.46	0.8	47.06	9.46	0.58	P	0.95	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11447	11447	G	C	MI.17771	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	688	230	V	L	Gta/Cta	0.72	0.94	0	benign	0.1	neutral	0.32	neutral	4.92	neutral	1.54	neutral	-2.05	low_impact	1.31	0.73	neutral	0.53	neutral	1.61	13.89	neutral	0.17	0.45	0.65	disease	0.7	disease	0.41	neutral	0.55	disease	1	0.64	neutral	0.61	deleterious	-6	neutral	0.28	neutral	0.18	medium_impact	0.02	medium_impact	0.17	medium_impact	0.24	0.8	18.52	20.7	0.35	N	0.50	polymorphism	1	0.03	rs2853492	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11447	11447	G	T	MI.17772	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	688	230	V	L	Gta/Tta	0.72	0.94	0	benign	0.1	neutral	0.32	neutral	4.92	neutral	1.54	neutral	-2.05	low_impact	1.31	0.73	neutral	0.53	neutral	1.76	14.75	neutral	0.17	0.45	0.65	disease	0.7	disease	0.41	neutral	0.55	disease	1	0.64	neutral	0.61	deleterious	-6	neutral	0.28	neutral	0.18	medium_impact	0.02	medium_impact	0.17	medium_impact	0.24	0.8	18.52	20.7	0.33	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11447	11447	G	A	MI.17773	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	688	230	V	M	Gta/Ata	0.72	0.94	0	benign	0.1	deleterious	0.01	neutral	4.55	neutral	-1.16	neutral	-2.25	medium_impact	2.52	0.73	neutral	0.76	neutral	1.79	14.92	neutral	0.15	0.45	0.87	disease	0.78	disease	0.61	disease	0.77	disease	5	0.99	deleterious	0.46	neutral	1	deleterious	0.30	neutral	0.18	medium_impact	-0.92	medium_impact	1.37	medium_impact	0.57	0.8	18.52	20.7	0.3	N	0.28	polymorphism	1	0.03	rs2853492	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11448	11448	T	G	MI.17774	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	689	230	V	G	gTa/gGa	0.03	0.94	0	possibly_damaging	0.74	deleterious	0	neutral	4.48	deleterious	-3.76	deleterious	-5.72	medium_impact	3.5	0.7	neutral	0.68	neutral	2.05	16.50	deleterious	0.02	0.35	0.95	disease	0.85	disease	0.6	disease	0.84	disease	7	1	deleterious	0.13	neutral	4	deleterious	0.47	deleterious	-1.14	low_impact	-1.48	low_impact	2.34	high_impact	0.31	0.8	18.52	20.7	0.4	N	0.95	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11448	11448	T	C	MI.17775	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	689	230	V	A	gTa/gCa	0.03	0.94	0	benign	0.35	deleterious	0.04	neutral	4.52	neutral	-1.97	deleterious	-3.27	medium_impact	3.04	0.74	neutral	0.71	neutral	1.71	14.45	neutral	0.08	0.35	0.82	disease	0.69	disease	0.58	disease	0.7	disease	4	0.95	neutral	0.35	neutral	1	deleterious	0.33	neutral	-0.47	medium_impact	-0.57	medium_impact	1.88	medium_impact	0.12	0.8	18.52	20.7	0.38	N	0.82	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11448	11448	T	A	MI.17776	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	689	230	V	E	gTa/gAa	0.03	0.94	0	possibly_damaging	0.8	deleterious	0	neutral	4.48	deleterious	-3.98	deleterious	-4.91	high_impact	3.85	0.71	neutral	0.55	neutral	3.12	22.60	deleterious	0.02	0.35	0.95	disease	0.92	disease	0.72	disease	0.85	disease	7	1	deleterious	0.1	neutral	5	deleterious	0.67	deleterious	-1.28	low_impact	-1.48	low_impact	2.68	high_impact	0.13	0.8	18.52	20.7	0.45	N	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11450	11450	C	T	MI.17777	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	691	231	L	F	Ctt/Ttt	-7.8	0	0	probably_damaging	0.98	deleterious	0	neutral	4.29	neutral	-2.86	deleterious	-3.27	high_impact	4.05	0.48	damaging	0.45	neutral	3.96	23.60	deleterious	0.05	0.35	0.77	disease	0.75	disease	0.65	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.31	low_impact	-1.48	low_impact	2.88	high_impact	0.42	0.8	46.84	9.41	0.43	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11450	11450	C	A	MI.17778	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	691	231	L	I	Ctt/Att	-7.8	0	0	possibly_damaging	0.68	deleterious	0	neutral	4.3	neutral	-2.63	neutral	-1.63	high_impact	4.25	0.43	damaging	0.52	neutral	4.15	23.80	deleterious	0.11	0.4	0.64	disease	0.7	disease	0.63	disease	0.66	disease	3	1	deleterious	0.16	neutral	5	deleterious	0.81	deleterious	-1.03	low_impact	-1.48	low_impact	3.08	high_impact	0.48	0.8	46.84	9.41	0.59	P	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11450	11450	C	G	MI.17779	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	691	231	L	V	Ctt/Gtt	-7.8	0	0	benign	0.22	deleterious	0	neutral	4.32	deleterious	-3.01	neutral	-2.45	high_impact	3.8	0.31	damaging	0.42	neutral	3.43	23.00	deleterious	0.07	0.35	0.62	disease	0.69	disease	0.64	disease	0.66	disease	3	1	deleterious	0.39	neutral	2	deleterious	0.81	deleterious	-0.2	medium_impact	-1.48	low_impact	2.63	high_impact	0.56	0.8	46.84	9.41	0.6	P	0.89	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8522	8522	C	T	MI.1778	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	157	53	P	S	Cca/Tca	-0.33	0	0	benign	0.01	neutral	0.44	neutral	2.07	neutral	1.3	neutral	0.77	neutral_impact	-0.82	1	neutral	0.94	neutral	-0.41	0.36	neutral	0.41986033	0.85	0.11	neutral	0.13	neutral	0.18	neutral	0.11	neutral	8	0.55	neutral	0.72	deleterious	-6	neutral	0.10	neutral	1.14	medium_impact	0.23	medium_impact	-1.8	low_impact	0.40	0.85	NA	NA	0.39	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11451	11451	T	G	MI.17780	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	692	231	L	R	cTt/cGt	0.03	0	0	probably_damaging	0.99	deleterious	0	neutral	4.22	deleterious	-4.92	deleterious	-4.91	high_impact	4.6	0.41	damaging	0.32	neutral	4.22	23.90	deleterious	0.02	0.35	0.68	disease	0.89	disease	0.75	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.59	low_impact	-1.48	low_impact	3.43	high_impact	0.12	0.8	46.84	9.41	0.67	P	1.00	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11451	11451	T	C	MI.17781	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	692	231	L	P	cTt/cCt	0.03	0	0	probably_damaging	0.99	deleterious	0	neutral	4.21	deleterious	-5.97	deleterious	-5.73	high_impact	4.25	0.38	damaging	0.4	neutral	3.93	23.50	deleterious	0.02	0.35	0.84	disease	0.84	disease	0.74	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.59	low_impact	-1.48	low_impact	3.08	high_impact	0.24	0.8	46.84	9.41	0.64	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11451	11451	T	A	MI.17782	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	692	231	L	H	cTt/cAt	0.03	0	0	probably_damaging	0.99	deleterious	0	neutral	4.43	neutral	-1.12	deleterious	-5.73	high_impact	3.8	0.39	damaging	0.38	neutral	4.18	23.80	deleterious	0.02	0.35	0.83	disease	0.82	disease	0.72	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.59	low_impact	-1.48	low_impact	2.63	high_impact	0.18	0.8	46.84	9.41	0.61	P	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11453	11453	G	C	MI.17783	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	694	232	A	P	Gcc/Ccc	-5.5	0	0	probably_damaging	1	deleterious	0	neutral	4.16	deleterious	-5.96	deleterious	-4.11	high_impact	4.59	0.49	damaging	0.31	neutral	3.83	23.40	deleterious	0.03	0.35	0.85	disease	0.91	disease	0.78	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.39	0.8	45.97	9.16	0.55	P	0.96	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11453	11453	G	A	MI.17784	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	694	232	A	T	Gcc/Acc	-5.5	0	0	probably_damaging	1	deleterious	0	neutral	4.2	deleterious	-3.96	deleterious	-3.28	high_impact	4.59	0.42	damaging	0.28	damaging	4.26	23.90	deleterious	0.07	0.35	0.65	disease	0.85	disease	0.68	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.66	0.8	45.97	9.16	0.58	P	0.82	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11453	11453	G	T	MI.17785	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	694	232	A	S	Gcc/Tcc	-5.5	0	0	probably_damaging	1	neutral	0.05	neutral	4.41	neutral	-0.88	neutral	-2.46	medium_impact	3.15	0.51	damaging	0.43	neutral	3.72	23.30	deleterious	0.21	0.45	0.5	neutral	0.88	disease	0.63	disease	0.72	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	-0.52	medium_impact	1.99	medium_impact	0.42	0.8	45.97	9.16	0.41	N	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11454	11454	C	A	MI.17786	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	695	232	A	D	gCc/gAc	9.01	1	0	probably_damaging	1	deleterious	0	neutral	4.18	deleterious	-5.44	deleterious	-4.92	high_impact	4.59	0.54	damaging	0.33	neutral	4.50	24.30	deleterious	0.02	0.35	0.87	disease	0.94	disease	0.77	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.31	0.8	45.97	9.16	0.64	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11454	11454	C	G	MI.17787	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	695	232	A	G	gCc/gGc	9.01	1	0	probably_damaging	1	deleterious	0	neutral	4.2	deleterious	-4.23	deleterious	-3.28	high_impact	3.69	0.47	damaging	0.44	neutral	4.00	23.60	deleterious	0.1	0.4	0.8	disease	0.82	disease	0.62	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.53	high_impact	0.59	0.8	45.97	9.16	0.62	P	0.79	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11454	11454	C	T	MI.17788	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	695	232	A	V	gCc/gTc	9.01	1	0	probably_damaging	1	deleterious	0.01	neutral	4.22	deleterious	-3.59	deleterious	-3.28	high_impact	4.59	0.4	damaging	0.3	neutral	4.52	24.30	deleterious	0.07	0.35	0.54	disease	0.9	disease	0.69	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-0.92	medium_impact	3.42	high_impact	0.60	0.8	45.97	9.16	0.78	P	0.72	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11456	11456	G	C	MI.17789	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	697	233	A	P	Gca/Cca	-7.57	0	0	probably_damaging	0.99	deleterious	0	neutral	4.4	deleterious	-5.2	deleterious	-4.13	high_impact	3.64	0.65	neutral	0.11	damaging	3.91	23.50	deleterious	0.03	0.35	0.84	disease	0.92	disease	0.7	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.59	low_impact	-1.48	low_impact	2.48	high_impact	0.54	0.8	46.41	9.37	0.28	N	0.96	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8523	8523	C	G	MI.1779	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	158	53	P	R	cCa/cGa	-0.1	0	0	benign	0.23	neutral	0.34	neutral	1.99	neutral	-0.21	neutral	0.05	low_impact	0.8	1	neutral	0.44	neutral	-0.20	1.12	neutral	0.38800886	0.85	0.21	neutral	0.22	neutral	0.36	neutral	0.11	neutral	8	0.59	neutral	0.56	deleterious	-6	neutral	0.23	neutral	-0.26	medium_impact	0.13	medium_impact	-0.41	medium_impact	0.62	0.85	NA	NA	0.48	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11456	11456	G	T	MI.17790	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	697	233	A	S	Gca/Tca	-7.57	0	0	possibly_damaging	0.9	neutral	0.1	neutral	4.52	neutral	-2.82	neutral	-2.47	medium_impact	2.19	0.72	neutral	0.16	damaging	3.75	23.30	deleterious	0.13	0.4	0.27	neutral	0.86	disease	0.55	disease	0.7	disease	4	0.96	neutral	0.1	neutral	0	NA	0.77	deleterious	-1.61	low_impact	-0.33	medium_impact	1.04	medium_impact	0.46	0.8	46.41	9.37	0.35	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11456	11456	G	A	MI.17791	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	697	233	A	T	Gca/Aca	-7.57	0	0	benign	0.42	deleterious	0	neutral	4.6	deleterious	-3.89	deleterious	-3.3	medium_impact	3.29	0.7	neutral	0.14	damaging	4.20	23.90	deleterious	0.06	0.35	0.22	neutral	0.83	disease	0.49	neutral	0.7	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.76	deleterious	-0.59	medium_impact	-1.48	low_impact	2.13	high_impact	0.70	0.85	46.41	9.37	0.37	N	0.82	polymorphism	1	0.16	.	.	.	.	.	.	COSM1155507	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11457	11457	C	A	MI.17792	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	698	233	A	E	gCa/gAa	4.17	1	0	probably_damaging	0.98	deleterious	0	neutral	4.42	deleterious	-5.37	deleterious	-4.13	high_impact	3.98	0.68	neutral	0.13	damaging	4.51	24.30	deleterious	0.02	0.35	0.8	disease	0.92	disease	0.7	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.31	low_impact	-1.48	low_impact	2.81	high_impact	0.33	0.8	46.41	9.37	0.54	P	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11457	11457	C	G	MI.17793	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	698	233	A	G	gCa/gGa	4.17	1	0	probably_damaging	0.92	neutral	1	neutral	4.56	neutral	-0.55	deleterious	-3.3	low_impact	1.01	0.66	neutral	0.17	damaging	3.99	23.60	deleterious	0.17	0.45	0.61	disease	0.5	disease	0.32	neutral	0.47	neutral	1	0.92	neutral	0.54	deleterious	-2	neutral	0.77	deleterious	-1.71	low_impact	1.88	high_impact	-0.13	medium_impact	0.64	0.8	46.41	9.37	0.4	N	0.79	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11457	11457	C	T	MI.17794	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	698	233	A	V	gCa/gTa	4.17	1	0	possibly_damaging	0.9	deleterious	0	neutral	4.48	deleterious	-3.5	deleterious	-3.3	high_impact	3.98	0.64	neutral	0.11	damaging	4.51	24.30	deleterious	0.05	0.35	0.72	disease	0.89	disease	0.58	disease	0.7	disease	4	1	deleterious	0.05	neutral	5	deleterious	0.86	deleterious	-1.61	low_impact	-1.48	low_impact	2.81	high_impact	0.53	0.8	46.41	9.37	0.61	P	0.72	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11459	11459	G	T	MI.17795	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	700	234	V	L	Gta/Tta	-11.71	0	0	benign	0.05	neutral	0.28	neutral	4.77	neutral	-1.1	neutral	-1.47	low_impact	1.58	0.71	neutral	0.59	neutral	3.71	23.30	deleterious	0.18	0.45	0.31	neutral	0.79	disease	0.37	neutral	0.52	disease	0	0.7	neutral	0.62	deleterious	-6	neutral	0.75	deleterious	0.48	medium_impact	-0.03	medium_impact	0.44	medium_impact	0.28	0.8	29.41	8.22	0.42	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11459	11459	G	C	MI.17796	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	700	234	V	L	Gta/Cta	-11.71	0	0	benign	0.05	neutral	0.28	neutral	4.77	neutral	-1.1	neutral	-1.47	low_impact	1.58	0.71	neutral	0.59	neutral	3.60	23.20	deleterious	0.18	0.45	0.31	neutral	0.79	disease	0.37	neutral	0.52	disease	0	0.7	neutral	0.62	deleterious	-6	neutral	0.75	deleterious	0.48	medium_impact	-0.03	medium_impact	0.44	medium_impact	0.28	0.8	29.41	8.22	0.41	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11459	11459	G	A	MI.17797	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	700	234	V	M	Gta/Ata	-11.71	0	0	benign	0.4	deleterious	0	neutral	4.56	deleterious	-3.56	neutral	-1.97	medium_impact	3.27	0.69	neutral	0.55	neutral	3.74	23.30	deleterious	0.12	0.4	0.56	disease	0.85	disease	0.6	disease	0.71	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.78	deleterious	-0.55	medium_impact	-1.48	low_impact	2.11	high_impact	0.56	0.8	29.41	8.22	0.36	N	0.56	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11460	11460	T	C	MI.17798	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	701	234	V	A	gTa/gCa	0.03	0	0	possibly_damaging	0.53	deleterious	0	neutral	4.63	neutral	-1.27	deleterious	-3.27	medium_impact	2.58	0.73	neutral	0.62	neutral	3.55	23.10	deleterious	0.09	0.35	0.17	neutral	0.77	disease	0.55	disease	0.67	disease	3	1	deleterious	0.24	neutral	4	deleterious	0.71	deleterious	-0.77	medium_impact	-1.48	low_impact	1.43	medium_impact	0.11	0.8	29.41	8.22	0.39	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11460	11460	T	G	MI.17799	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	701	234	V	G	gTa/gGa	0.03	0	0	probably_damaging	0.91	deleterious	0.04	neutral	4.52	deleterious	-3.28	deleterious	-5.73	medium_impact	2.85	0.71	neutral	0.54	neutral	3.82	23.40	deleterious	0.03	0.35	0.69	disease	0.88	disease	0.6	disease	0.72	disease	4	0.99	deleterious	0.07	neutral	5	deleterious	0.82	deleterious	-1.66	low_impact	-0.57	medium_impact	1.69	medium_impact	0.19	0.8	29.41	8.22	0.35	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8609	8609	C	G	MI.178	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	83	28	P	R	cCt/cGt	-0.57	0	0	possibly_damaging	0.77	neutral	0.06	neutral	4.4	neutral	0.62	neutral	-0.42	low_impact	1.15	0.87	neutral	0.41	neutral	1.74	14.64	neutral	0.29	0.65	0.31	neutral	0.53	disease	0.54	disease	0.66	disease	3	0.96	neutral	0.15	neutral	-3	neutral	0.57	deleterious	-1.25	low_impact	-0.38	medium_impact	-0.11	medium_impact	0.70	0.9	31.86	20.94	0.37	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8523	8523	C	T	MI.1780	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	158	53	P	L	cCa/cTa	-0.1	0	0	benign	0.11	neutral	0.68	neutral	2.02	neutral	0.49	neutral	0.38	neutral_impact	-1.52	0.99	neutral	0.88	neutral	0.69	8.75	deleterious	0.51005936	0.85	0.18	neutral	0.11	neutral	0.24	neutral	0.05	neutral	9	0.21	neutral	0.79	deleterious	-6	neutral	0.15	neutral	0.11	medium_impact	0.48	medium_impact	-2.4	low_impact	0.70	0.85	NA	NA	0.43	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11460	11460	T	A	MI.17800	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	701	234	V	E	gTa/gAa	0.03	0	0	probably_damaging	0.95	deleterious	0	neutral	4.51	deleterious	-5.01	deleterious	-4.92	high_impact	3.83	0.7	neutral	0.45	neutral	4.81	24.80	deleterious	0.02	0.35	0.7	disease	0.94	disease	0.73	disease	0.87	disease	7	1	deleterious	0.03	neutral	6	deleterious	0.88	deleterious	-1.92	low_impact	-1.48	low_impact	2.66	high_impact	0.14	0.8	29.41	8.22	0.41	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11462	11462	C	G	MI.17801	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	703	235	L	V	Ctc/Gtc	-8.03	0	0	possibly_damaging	0.86	deleterious	0	neutral	4.25	neutral	-0.99	neutral	-2.49	medium_impact	3.13	0.64	neutral	0.49	neutral	3.45	23.00	deleterious	0.33	0.5	0.33	neutral	0.75	disease	0.59	disease	0.66	disease	3	1	deleterious	0.07	neutral	4	deleterious	0.77	deleterious	-1.46	low_impact	-1.48	low_impact	1.97	medium_impact	0.50	0.8	46.84	9.48	0.4	N	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11462	11462	C	T	MI.17802	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	703	235	L	F	Ctc/Ttc	-8.03	0	0	benign	0.29	deleterious	0	neutral	4.18	deleterious	-3.54	deleterious	-3.31	high_impact	3.72	0.6	damaging	0.5	neutral	4.01	23.60	deleterious	0.15	0.4	0.71	disease	0.78	disease	0.6	disease	0.67	disease	3	1	deleterious	0.36	neutral	2	deleterious	0.84	deleterious	-0.35	medium_impact	-1.48	low_impact	2.55	high_impact	0.36	0.8	46.84	9.48	0.37	N	0.99	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11462	11462	C	A	MI.17803	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	703	235	L	I	Ctc/Atc	-8.03	0	0	possibly_damaging	0.86	neutral	0.05	neutral	4.24	neutral	-2.18	neutral	-1.66	medium_impact	3.37	0.67	neutral	0.58	neutral	4.12	23.80	deleterious	0.3	0.45	0.34	neutral	0.77	disease	0.58	disease	0.66	disease	3	0.97	neutral	0.1	neutral	0	NA	0.76	deleterious	-1.46	low_impact	-0.52	medium_impact	2.21	high_impact	0.52	0.8	46.84	9.48	0.48	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11463	11463	T	C	MI.17804	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	704	235	L	P	cTc/cCc	0.26	0.01	0	probably_damaging	0.99	deleterious	0	neutral	4.21	deleterious	-4.85	deleterious	-5.8	high_impact	3.83	0.59	damaging	0.48	neutral	3.98	23.60	deleterious	0.01	0.35	0.86	disease	0.87	disease	0.7	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.59	low_impact	-1.48	low_impact	2.66	high_impact	0.24	0.8	46.84	9.48	0.35	N	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11463	11463	T	G	MI.17805	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	704	235	L	R	cTc/cGc	0.26	0.01	0	probably_damaging	0.99	deleterious	0	neutral	4.16	deleterious	-4.75	deleterious	-4.97	high_impact	4.52	0.59	damaging	0.39	neutral	4.19	23.80	deleterious	0.01	0.35	0.82	disease	0.92	disease	0.71	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.59	low_impact	-1.48	low_impact	3.35	high_impact	0.17	0.8	46.84	9.48	0.47	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11463	11463	T	A	MI.17806	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	704	235	L	H	cTc/cAc	0.26	0.01	0	probably_damaging	0.99	deleterious	0	neutral	4.15	deleterious	-4.79	deleterious	-5.8	high_impact	4.52	0.63	neutral	0.41	neutral	4.35	24.10	deleterious	0.03	0.35	0.87	disease	0.84	disease	0.67	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.59	low_impact	-1.48	low_impact	3.35	high_impact	0.26	0.8	46.84	9.48	0.43	N	0.96	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11465	11465	T	G	MI.17807	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	706	236	L	V	Tta/Gta	-3.42	0	0	probably_damaging	1	deleterious	0	neutral	4.79	neutral	0.63	deleterious	-2.51	high_impact	4.05	0.36	damaging	0.53	neutral	3.42	23.00	deleterious	0.34	0.5	0.62	disease	0.75	disease	0.58	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.88	high_impact	0.56	0.8	47.06	9.26	0.65	P	0.89	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11465	11465	T	A	MI.17808	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	706	236	L	M	Tta/Ata	-3.42	0	0	probably_damaging	1	deleterious	0.04	neutral	4.36	deleterious	-3.43	neutral	-1.68	high_impact	3.7	0.4	damaging	0.63	neutral	3.59	23.20	deleterious	0.32	0.5	0.28	neutral	0.73	disease	0.57	disease	0.65	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.72	deleterious	-3.54	low_impact	-0.57	medium_impact	2.53	high_impact	0.52	0.8	47.06	9.26	0.58	P	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11466	11466	T	G	MI.17809	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	707	236	L	W	tTa/tGa	0.49	0.06	0	probably_damaging	1	deleterious	0	neutral	4.34	deleterious	-6.05	deleterious	-5.03	high_impact	4.25	0.41	damaging	0.47	neutral	3.76	23.30	deleterious	0.04	0.35	0.93	disease	0.81	disease	0.61	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.21	0.8	47.06	9.26	0.59	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8523	8523	C	A	MI.1781	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	158	53	P	Q	cCa/cAa	-0.1	0	0	benign	0.29	neutral	0.29	neutral	2.01	neutral	0.27	neutral	0.29	neutral_impact	0.26	1	neutral	0.61	neutral	0.37	6.37	deleterious	0.34926686	0.85	0.2	neutral	0.23	neutral	0.31	neutral	0.14	neutral	7	0.65	neutral	0.5	deleterious	-6	neutral	0.19	neutral	-0.39	medium_impact	0.07	medium_impact	-0.88	medium_impact	0.55	0.85	NA	NA	0.49	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11466	11466	T	C	MI.17810	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	707	236	L	S	tTa/tCa	0.49	0.06	0	probably_damaging	1	deleterious	0	neutral	4.36	deleterious	-3.63	deleterious	-5.03	high_impact	3.7	0.38	damaging	0.6	neutral	3.78	23.40	deleterious	0.03	0.35	0.74	disease	0.83	disease	0.6	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.53	high_impact	0.19	0.8	47.06	9.26	0.63	P	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11467	11467	A	C	MI.17811	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	708	236	L	F	ttA/ttC	7.4	0.96	0.26	probably_damaging	1	deleterious	0	neutral	4.36	deleterious	-3.58	deleterious	-3.35	high_impact	4.6	0.39	damaging	0.49	neutral	3.49	23.10	deleterious	0.15	0.4	0.78	disease	0.76	disease	0.59	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.43	high_impact	0.43	0.8	47.06	9.26	0.77	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11467	11467	A	T	MI.17812	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	708	236	L	F	ttA/ttT	7.4	0.96	0.26	probably_damaging	1	deleterious	0	neutral	4.36	deleterious	-3.58	deleterious	-3.35	high_impact	4.6	0.39	damaging	0.49	neutral	3.65	23.20	deleterious	0.15	0.4	0.78	disease	0.76	disease	0.59	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.43	high_impact	0.43	0.8	47.06	9.26	0.77	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11468	11468	A	C	MI.17813	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	709	237	K	Q	Aaa/Caa	-2.5	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-4.28	deleterious	-3.28	high_impact	4.24	0.6	neutral	0.14	damaging	3.46	23.00	deleterious	0.11	0.4	0.52	disease	0.8	disease	0.68	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.07	high_impact	0.33	0.8	46.62	9.35	0.4	N	0.86	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11468	11468	A	G	MI.17814	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	709	237	K	E	Aaa/Gaa	-2.5	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-3.83	deleterious	-3.28	high_impact	4.59	0.6	damaging	0.16	damaging	4.01	23.60	deleterious	0.08	0.35	0.34	neutral	0.86	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.36	0.8	46.62	9.35	0.49	N	0.87	polymorphism	1	0.32	rs878972941	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11469	11469	A	C	MI.17815	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	710	237	K	T	aAa/aCa	6.7	1	0	probably_damaging	1	deleterious	0	neutral	4.59	neutral	-2.55	deleterious	-4.92	high_impact	4.24	0.66	neutral	0.12	damaging	3.60	23.20	deleterious	0.07	0.35	0.55	disease	0.81	disease	0.67	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.07	high_impact	0.23	0.8	46.62	9.35	0.61	P	0.77	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11469	11469	A	T	MI.17816	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	710	237	K	M	aAa/aTa	6.7	1	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-6.1	deleterious	-4.99	high_impact	4.59	0.63	neutral	0.13	damaging	3.83	23.40	deleterious	0.07	0.35	0.47	neutral	0.86	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.28	0.8	46.62	9.35	0.56	P	0.42	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11470	11470	A	T	MI.17817	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	711	237	K	N	aaA/aaT	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.47	deleterious	-3.5	deleterious	-3.9	medium_impact	3.44	0.59	damaging	0.16	damaging	3.80	23.40	deleterious	0.17	0.45	0.68	disease	0.8	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.24	0.8	46.62	9.35	0.57	P	0.72	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11470	11470	A	C	MI.17818	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	711	237	K	N	aaA/aaC	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.47	deleterious	-3.5	deleterious	-3.9	medium_impact	3.44	0.59	damaging	0.16	damaging	3.75	23.30	deleterious	0.17	0.45	0.68	disease	0.8	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.24	0.8	46.62	9.35	0.56	P	0.72	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	A11470C	MELAS	-	+	Reported	1	.	.	.	damaging
chrM	11471	11471	C	G	MI.17819	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	712	238	L	V	Cta/Gta	0.95	0.97	0	possibly_damaging	0.9	deleterious	0	neutral	4.48	neutral	0.66	deleterious	-2.56	medium_impact	3.41	0.54	damaging	0.1	damaging	3.43	23.00	deleterious	0.36	0.5	0.56	disease	0.73	disease	0.62	disease	0.65	disease	3	1	deleterious	0.05	neutral	4	deleterious	0.80	deleterious	-1.61	low_impact	-1.48	low_impact	2.25	high_impact	0.57	0.8	46.62	9.3	0.43	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8525	8525	A	C	MI.1782	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	160	54	K	Q	Aaa/Caa	0.13	0	0	probably_damaging	0.99	neutral	0.45	neutral	1.73	deleterious	-5.01	deleterious	-3.82	high_impact	3.52	0.98	neutral	0.44	neutral	3.42	23.00	deleterious	0.44021289	0.85	0.66	disease	0.66	disease	0.69	disease	0.64	disease	3	0.99	deleterious	0.23	neutral	2	deleterious	0.82	deleterious	-2.65	low_impact	0.24	medium_impact	1.92	medium_impact	0.54	0.85	16.18	8.12	0.43	N	0.80	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11471	11471	C	A	MI.17820	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	712	238	L	M	Cta/Ata	0.95	0.97	0	possibly_damaging	0.76	deleterious	0.04	neutral	4.44	neutral	-0.36	neutral	-1.7	medium_impact	2.44	0.57	damaging	0.24	damaging	3.95	23.60	deleterious	0.38	0.5	0.68	disease	0.68	disease	0.5	neutral	0.49	neutral	0	0.97	neutral	0.14	neutral	4	deleterious	0.78	deleterious	-1.19	low_impact	-0.57	medium_impact	1.29	medium_impact	0.50	0.8	46.62	9.3	0.48	N	0.90	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11472	11472	T	G	MI.17821	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	713	238	L	R	cTa/cGa	0.26	0.95	0	probably_damaging	0.98	deleterious	0	neutral	4.37	deleterious	-3.75	deleterious	-5.12	high_impact	4.5	0.56	damaging	0.08	damaging	4.26	23.90	deleterious	0.02	0.35	0.83	disease	0.91	disease	0.75	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-2.31	low_impact	-1.48	low_impact	3.33	high_impact	0.13	0.8	46.62	9.3	0.54	P	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11472	11472	T	A	MI.17822	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	713	238	L	Q	cTa/cAa	0.26	0.95	0	probably_damaging	0.99	deleterious	0	neutral	4.37	deleterious	-3.93	deleterious	-5.12	high_impact	4.16	0.53	damaging	0.1	damaging	4.42	24.20	deleterious	0.03	0.35	0.84	disease	0.84	disease	0.63	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.59	low_impact	-1.48	low_impact	2.99	high_impact	0.22	0.8	46.62	9.3	0.42	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11472	11472	T	C	MI.17823	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	713	238	L	P	cTa/cCa	0.26	0.95	0	probably_damaging	1	deleterious	0	neutral	4.36	deleterious	-4.23	deleterious	-5.98	high_impact	4.5	0.51	damaging	0.08	damaging	4.00	23.60	deleterious	0.02	0.35	0.87	disease	0.85	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.16	0.8	46.62	9.3	0.51	P	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11474	11474	G	C	MI.17824	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	715	239	G	R	Ggc/Cgc	-1.35	0.01	0	probably_damaging	1	deleterious	0	neutral	4.16	deleterious	-6.2	deleterious	-6.86	high_impact	3.92	0.48	damaging	0.25	damaging	3.89	23.50	deleterious	0.02	0.35	0.64	disease	0.92	disease	0.82	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	2.75	high_impact	0.48	0.8	46.84	9.18	0.49	N	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11474	11474	G	T	MI.17825	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	715	239	G	C	Ggc/Tgc	-1.35	0.01	0	probably_damaging	1	deleterious	0	neutral	4.14	deleterious	-7.84	deleterious	-7.72	high_impact	4.62	0.48	damaging	0.24	damaging	4.14	23.80	deleterious	0.02	0.35	0.91	disease	0.91	disease	0.75	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.25	0.8	46.84	9.18	0.48	N	0.98	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11474	11474	G	A	MI.17826	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	715	239	G	S	Ggc/Agc	-1.35	0.01	0	probably_damaging	1	deleterious	0	neutral	4.21	deleterious	-4.52	deleterious	-5.14	high_impact	3.58	0.5	damaging	0.4	neutral	4.18	23.80	deleterious	0.03	0.35	0.57	disease	0.86	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	2.42	high_impact	0.66	0.8	46.84	9.18	0.41	N	0.97	polymorphism	1	0.20	rs28371977	.	.	.	.	.	COSM1155508	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11475	11475	G	T	MI.17827	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	716	239	G	V	gGc/gTc	9.01	1	0.01	probably_damaging	1	deleterious	0	neutral	4.17	deleterious	-5.67	deleterious	-7.72	high_impact	4.07	0.47	damaging	0.33	neutral	3.76	23.30	deleterious	0.02	0.35	0.73	disease	0.92	disease	0.74	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.9	high_impact	0.20	0.8	46.84	9.18	0.61	P	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11475	11475	G	A	MI.17828	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	716	239	G	D	gGc/gAc	9.01	1	0.01	probably_damaging	1	deleterious	0	neutral	4.16	deleterious	-6.72	deleterious	-6	high_impact	4.62	0.47	damaging	0.3	neutral	3.86	23.50	deleterious	0.02	0.35	0.59	disease	0.92	disease	0.81	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.15	0.8	46.84	9.18	0.67	P	0.99	polymorphism	1	0.44	.	.	.	.	.	pituitary oncocytoma	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11475	11475	G	C	MI.17829	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	716	239	G	A	gGc/gCc	9.01	1	0.01	probably_damaging	1	deleterious	0	neutral	4.27	neutral	-2.32	deleterious	-5.14	medium_impact	3.23	0.54	damaging	0.43	neutral	3.14	22.60	deleterious	0.07	0.35	0.3	neutral	0.79	disease	0.7	disease	0.69	disease	4	1	deleterious	0	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	2.07	high_impact	0.32	0.8	46.84	9.18	0.54	P	0.76	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8525	8525	A	G	MI.1783	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	160	54	K	E	Aaa/Gaa	0.13	0	0	probably_damaging	0.97	neutral	0.53	neutral	1.72	deleterious	-4.91	deleterious	-3.8	high_impact	3.52	0.99	neutral	0.59	neutral	2.96	22.10	deleterious	0.20859529	0.85	0.66	disease	0.53	disease	0.68	disease	0.37	neutral	3	0.97	neutral	0.28	neutral	2	deleterious	0.83	deleterious	-2.19	low_impact	0.32	medium_impact	1.92	medium_impact	0.48	0.85	16.18	8.12	0.41	N	0.86	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11477	11477	G	A	MI.17830	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	718	240	G	S	Ggc/Agc	-13.55	0	0	probably_damaging	1	neutral	0.1	neutral	4.53	neutral	-1.76	deleterious	-4.96	low_impact	1.9	0.61	neutral	0.45	neutral	4.16	23.80	deleterious	0.07	0.35	0.33	neutral	0.85	disease	0.57	disease	0.65	disease	3	1	deleterious	0.05	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	-0.33	medium_impact	0.75	medium_impact	0.71	0.85	22.22	8.72	0.28	N	0.51	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11477	11477	G	C	MI.17831	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	718	240	G	R	Ggc/Cgc	-13.55	0	0	probably_damaging	1	deleterious	0	neutral	4.51	neutral	-2.89	deleterious	-6.74	high_impact	4.38	0.68	neutral	0.11	damaging	4.00	23.60	deleterious	0.03	0.35	0.56	disease	0.93	disease	0.77	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.21	high_impact	0.28	0.8	22.22	8.72	0.47	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11477	11477	G	T	MI.17832	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	718	240	G	C	Ggc/Tgc	-13.55	0	0	probably_damaging	1	deleterious	0.02	neutral	4.51	deleterious	-3.34	deleterious	-7.58	medium_impact	3.23	0.66	neutral	0.11	damaging	4.19	23.90	deleterious	0.04	0.35	0.72	disease	0.91	disease	0.59	disease	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-0.75	medium_impact	2.07	high_impact	0.23	0.8	22.22	8.72	0.29	N	0.89	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11478	11478	G	A	MI.17833	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	719	240	G	D	gGc/gAc	5.09	1	0	probably_damaging	1	deleterious	0	neutral	4.5	deleterious	-4.21	deleterious	-5.88	high_impact	3.68	0.71	neutral	0.12	damaging	3.82	23.40	deleterious	0.02	0.35	0.49	neutral	0.93	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.52	high_impact	0.20	0.8	22.22	8.72	0.55	P	0.93	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11478	11478	G	T	MI.17834	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	719	240	G	V	gGc/gTc	5.09	1	0	probably_damaging	1	deleterious	0.02	neutral	4.69	neutral	1.79	deleterious	-7.6	medium_impact	3.02	0.65	neutral	0.12	damaging	3.81	23.40	deleterious	0.04	0.35	0.29	neutral	0.92	disease	0.67	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-0.75	medium_impact	1.86	medium_impact	0.24	0.8	22.22	8.72	0.49	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11478	11478	G	C	MI.17835	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	719	240	G	A	gGc/gCc	5.09	1	0	probably_damaging	1	deleterious	0.03	neutral	4.58	neutral	0.82	deleterious	-5.02	medium_impact	2.55	0.69	neutral	0.17	damaging	3.15	22.60	deleterious	0.12	0.4	0.4	neutral	0.79	disease	0.63	disease	0.67	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-0.64	medium_impact	1.4	medium_impact	0.30	0.8	22.22	8.72	0.52	P	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11480	11480	T	A	MI.17836	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	721	241	Y	N	Tat/Aat	-10.79	0	0	probably_damaging	1	deleterious	0	neutral	4.31	deleterious	-6.38	deleterious	-7.75	high_impact	4.59	0.56	damaging	0.41	neutral	4.11	23.70	deleterious	0.05	0.35	0.47	neutral	0.88	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.32	0.8	46.62	9.38	0.51	N	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11480	11480	T	C	MI.17837	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	721	241	Y	H	Tat/Cat	-10.79	0	0	probably_damaging	1	deleterious	0	neutral	4.3	deleterious	-6.48	deleterious	-4.31	high_impact	4.04	0.56	damaging	0.35	neutral	3.64	23.20	deleterious	0.11	0.4	0.7	disease	0.86	disease	0.83	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.32	0.8	46.62	9.38	0.42	N	0.97	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11480	11480	T	G	MI.17838	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	721	241	Y	D	Tat/Gat	-10.79	0	0	probably_damaging	1	deleterious	0	neutral	4.3	deleterious	-7.3	deleterious	-8.62	high_impact	4.59	0.69	neutral	0.37	neutral	4.04	23.70	deleterious	0.03	0.35	0.35	neutral	0.92	disease	0.83	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.23	0.8	46.62	9.38	0.53	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11481	11481	A	G	MI.17839	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	722	241	Y	C	tAt/tGt	7.4	1	0	probably_damaging	1	deleterious	0.01	neutral	4.31	deleterious	-6.34	deleterious	-7.76	high_impact	4.59	0.54	damaging	0.29	neutral	3.60	23.20	deleterious	0.05	0.35	0.9	disease	0.89	disease	0.8	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-0.92	medium_impact	3.42	high_impact	0.21	0.8	46.62	9.38	0.63	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8526	8526	A	T	MI.1784	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	161	54	K	M	aAa/aTa	3.83	0.99	0	probably_damaging	1	neutral	0.24	neutral	1.68	deleterious	-7.2	deleterious	-5.75	medium_impact	2.98	1	neutral	0.5	neutral	3.88	23.50	deleterious	0.18776742	0.85	0.89	disease	0.52	disease	0.69	disease	0.66	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.01	medium_impact	1.46	medium_impact	0.40	0.85	16.18	8.12	0.64	P	0.69	disease_causing	0.83	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11481	11481	A	T	MI.17840	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	722	241	Y	F	tAt/tTt	7.4	1	0	probably_damaging	1	neutral	0.08	neutral	4.44	neutral	-1.17	deleterious	-3.45	medium_impact	2.82	0.59	damaging	0.42	neutral	3.54	23.10	deleterious	0.16	0.45	0.82	disease	0.84	disease	0.68	disease	0.72	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	-0.39	medium_impact	1.66	medium_impact	0.57	0.8	46.62	9.38	0.63	P	0.79	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11481	11481	A	C	MI.17841	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	722	241	Y	S	tAt/tCt	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.37	deleterious	-5.05	deleterious	-7.75	high_impact	4.59	0.6	neutral	0.49	neutral	3.87	23.50	deleterious	0.05	0.35	0.38	neutral	0.88	disease	0.76	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.33	0.8	46.62	9.38	0.58	P	0.95	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11483	11483	G	T	MI.17842	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	724	242	G	C	Ggt/Tgt	-6.19	0	0	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-4.35	deleterious	-7.78	high_impact	4.63	0.49	damaging	0.22	damaging	4.17	23.80	deleterious	0.04	0.35	0.81	disease	0.93	disease	0.71	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.20	0.8	45.97	9.19	0.47	N	0.98	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11483	11483	G	C	MI.17843	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	724	242	G	R	Ggt/Cgt	-6.19	0	0	possibly_damaging	0.58	deleterious	0	neutral	4.45	deleterious	-4.87	deleterious	-6.92	high_impact	4.29	0.43	damaging	0.23	damaging	4.00	23.60	deleterious	0.04	0.35	0.73	disease	0.94	disease	0.8	disease	0.83	disease	7	1	deleterious	0.21	neutral	5	deleterious	0.90	deleterious	-0.85	medium_impact	-1.48	low_impact	3.12	high_impact	0.42	0.8	45.97	9.19	0.56	P	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11483	11483	G	A	MI.17844	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	724	242	G	S	Ggt/Agt	-6.19	0	0	probably_damaging	0.98	deleterious	0	neutral	4.47	deleterious	-3.2	deleterious	-5.19	high_impact	4.29	0.52	damaging	0.33	neutral	4.28	24.00	deleterious	0.06	0.35	0.47	neutral	0.88	disease	0.7	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.31	low_impact	-1.48	low_impact	3.12	high_impact	0.57	0.8	45.97	9.19	0.44	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11484	11484	G	C	MI.17845	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	725	242	G	A	gGt/gCt	6.01	1	0	probably_damaging	0.94	deleterious	0	neutral	4.5	neutral	-0.56	deleterious	-5.19	medium_impact	3.43	0.55	damaging	0.39	neutral	3.09	22.50	deleterious	0.09	0.35	0.53	disease	0.83	disease	0.67	disease	0.68	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.83	deleterious	-1.84	low_impact	-1.48	low_impact	2.27	high_impact	0.36	0.8	45.97	9.19	0.59	P	0.76	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11484	11484	G	T	MI.17846	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	725	242	G	V	gGt/gTt	6.01	1	0	probably_damaging	0.99	deleterious	0	neutral	4.57	neutral	-1.9	deleterious	-7.78	high_impact	4.29	0.49	damaging	0.29	neutral	3.78	23.40	deleterious	0.04	0.35	0.47	neutral	0.93	disease	0.71	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.59	low_impact	-1.48	low_impact	3.12	high_impact	0.25	0.8	45.97	9.19	0.65	P	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11484	11484	G	A	MI.17847	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	725	242	G	D	gGt/gAt	6.01	1	0	probably_damaging	0.99	deleterious	0	neutral	4.44	deleterious	-6.02	deleterious	-6.05	high_impact	4.63	0.54	damaging	0.28	damaging	3.80	23.40	deleterious	0.03	0.35	0.81	disease	0.93	disease	0.79	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.59	low_impact	-1.48	low_impact	3.45	high_impact	0.28	0.8	45.97	9.19	0.59	P	0.99	polymorphism	1	0.44	.	.	.	.	.	.	COSM1155509	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11486	11486	A	G	MI.17848	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	727	243	M	V	Ata/Gta	-14.94	0	0	possibly_damaging	0.53	neutral	0.22	neutral	4.64	neutral	-0.01	neutral	-2.5	low_impact	1.4	0.72	neutral	0.59	neutral	2.72	20.90	deleterious	0.12	0.4	0.75	disease	0.77	disease	0.62	disease	0.66	disease	3	0.77	neutral	0.35	neutral	-3	neutral	0.71	deleterious	-0.77	medium_impact	-0.11	medium_impact	0.26	medium_impact	0.50	0.8	16.99	22.09	0.32	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11486	11486	A	T	MI.17849	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	727	243	M	L	Ata/Tta	-14.94	0	0	benign	0.03	neutral	1	neutral	5.27	neutral	2.7	neutral	-1.92	neutral_impact	0.34	0.73	neutral	0.59	neutral	3.31	22.90	deleterious	0.16	0.45	0.57	disease	0.62	disease	0.49	neutral	0.47	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.61	deleterious	0.7	medium_impact	1.88	high_impact	-0.79	medium_impact	0.48	0.8	16.99	22.09	0.28	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8526	8526	A	C	MI.1785	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	161	54	K	T	aAa/aCa	3.83	0.99	0	probably_damaging	0.98	neutral	0.55	neutral	1.71	deleterious	-5.6	deleterious	-5.74	medium_impact	2.42	1	neutral	0.73	neutral	3.63	23.20	deleterious	0.30462661	0.85	0.75	disease	0.66	disease	0.65	disease	0.63	disease	3	0.98	deleterious	0.29	neutral	1	deleterious	0.85	deleterious	-2.36	low_impact	0.34	medium_impact	0.98	medium_impact	0.33	0.85	16.18	8.12	0.56	P	0.81	disease_causing	0.68	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11486	11486	A	C	MI.17850	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	727	243	M	L	Ata/Cta	-14.94	0	0	benign	0.03	neutral	1	neutral	5.27	neutral	2.7	neutral	-1.92	neutral_impact	0.34	0.73	neutral	0.59	neutral	3.21	22.70	deleterious	0.16	0.45	0.57	disease	0.62	disease	0.49	neutral	0.47	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.61	deleterious	0.7	medium_impact	1.88	high_impact	-0.79	medium_impact	0.48	0.8	16.99	22.09	0.28	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11487	11487	T	A	MI.17851	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	728	243	M	K	aTa/aAa	5.55	1	0	possibly_damaging	0.89	deleterious	0	neutral	4.5	deleterious	-3.86	deleterious	-4.86	medium_impact	3.48	0.7	neutral	0.43	neutral	3.88	23.50	deleterious	0.02	0.35	0.82	disease	0.91	disease	0.74	disease	0.79	disease	6	1	deleterious	0.06	neutral	4	deleterious	0.85	deleterious	-1.57	low_impact	-1.48	low_impact	2.32	high_impact	0.35	0.8	16.99	22.09	0.61	P	0.95	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11487	11487	T	C	MI.17852	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	728	243	M	T	aTa/aCa	5.55	1	0	possibly_damaging	0.78	deleterious	0	neutral	4.52	neutral	-2.45	deleterious	-4.54	medium_impact	3.14	0.7	neutral	0.53	neutral	2.94	22.00	deleterious	0.06	0.35	0.76	disease	0.78	disease	0.67	disease	0.73	disease	5	1	deleterious	0.11	neutral	4	deleterious	0.82	deleterious	-1.23	low_impact	-1.48	low_impact	1.98	medium_impact	0.28	0.8	16.99	22.09	0.61	P	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11488	11488	A	C	MI.17853	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	729	243	M	I	atA/atC	7.4	1	0	benign	0.4	neutral	0.75	neutral	4.73	neutral	0.66	neutral	-2.33	neutral_impact	0.08	0.7	neutral	0.68	neutral	2.03	16.43	deleterious	0.14	0.4	0.62	disease	0.26	neutral	0.4	neutral	0.56	disease	1	0.29	neutral	0.68	deleterious	-6	neutral	0.67	deleterious	-0.55	medium_impact	0.47	medium_impact	-1.05	low_impact	0.56	0.8	16.99	22.09	0.56	P	0.51	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11488	11488	A	T	MI.17854	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	729	243	M	I	atA/atT	7.4	1	0	benign	0.4	neutral	0.75	neutral	4.73	neutral	0.66	neutral	-2.33	neutral_impact	0.08	0.7	neutral	0.68	neutral	2.10	16.86	deleterious	0.14	0.4	0.62	disease	0.26	neutral	0.4	neutral	0.56	disease	1	0.29	neutral	0.68	deleterious	-6	neutral	0.67	deleterious	-0.55	medium_impact	0.47	medium_impact	-1.05	low_impact	0.56	0.8	16.99	22.09	0.56	P	0.51	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11489	11489	A	G	MI.17855	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	730	244	M	V	Ata/Gta	-1.81	0	0	benign	0.17	deleterious	0.04	neutral	4.71	neutral	1.17	neutral	-2.47	low_impact	1.3	0.78	neutral	0.65	neutral	2.76	21.20	deleterious	0.15	0.4	0.69	disease	0.72	disease	0.46	neutral	0.41	neutral	2	0.95	neutral	0.44	neutral	-2	neutral	0.66	deleterious	-0.07	medium_impact	-0.57	medium_impact	0.16	medium_impact	0.37	0.8	8.93	21.34	0.3	N	0.64	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11489	11489	A	C	MI.17856	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	730	244	M	L	Ata/Cta	-1.81	0	0	benign	0.01	neutral	0.96	neutral	4.74	neutral	2.43	neutral	-1.53	neutral_impact	-0.12	0.8	neutral	0.98	neutral	1.94	15.86	deleterious	0.16	0.45	0.51	disease	0.58	disease	0.38	neutral	0.37	neutral	3	0.01	neutral	0.98	deleterious	-6	neutral	0.56	deleterious	1.16	medium_impact	0.98	medium_impact	-1.25	low_impact	0.33	0.8	8.93	21.34	0.28	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11489	11489	A	T	MI.17857	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	730	244	M	L	Ata/Tta	-1.81	0	0	benign	0.01	neutral	0.96	neutral	4.74	neutral	2.43	neutral	-1.53	neutral_impact	-0.12	0.8	neutral	0.98	neutral	2.01	16.30	deleterious	0.16	0.45	0.51	disease	0.58	disease	0.38	neutral	0.37	neutral	3	0.01	neutral	0.98	deleterious	-6	neutral	0.56	deleterious	1.16	medium_impact	0.98	medium_impact	-1.25	low_impact	0.33	0.8	8.93	21.34	0.28	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11490	11490	T	C	MI.17858	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	731	244	M	T	aTa/aCa	0.72	0.08	0	possibly_damaging	0.56	deleterious	0.02	neutral	4.61	neutral	-0.78	deleterious	-4.36	medium_impact	2.54	0.67	neutral	0.52	neutral	3.04	22.40	deleterious	0.06	0.35	0.55	disease	0.73	disease	0.62	disease	0.67	disease	3	0.98	neutral	0.23	neutral	4	deleterious	0.74	deleterious	-0.82	medium_impact	-0.75	medium_impact	1.39	medium_impact	0.23	0.8	8.93	21.34	0.37	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11490	11490	T	A	MI.17859	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	731	244	M	K	aTa/aAa	0.72	0.08	0	possibly_damaging	0.81	deleterious	0	neutral	4.52	neutral	-2.46	deleterious	-4.68	medium_impact	3	0.68	neutral	0.43	neutral	4.15	23.80	deleterious	0.02	0.35	0.32	neutral	0.89	disease	0.7	disease	0.74	disease	5	1	deleterious	0.1	neutral	4	deleterious	0.75	deleterious	-1.31	low_impact	-1.48	low_impact	1.84	medium_impact	0.28	0.8	8.93	21.34	0.43	N	0.90	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8527	8527	A	T	MI.1786	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	162	54	K	N	aaA/aaT	2.21	1	0	probably_damaging	0.99	neutral	0.44	neutral	1.69	deleterious	-5.5	deleterious	-4.62	high_impact	3.52	0.98	neutral	0.45	neutral	3.94	23.60	deleterious	0.37793802	0.85	0.73	disease	0.66	disease	0.68	disease	0.63	disease	3	0.99	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-2.65	low_impact	0.23	medium_impact	1.92	medium_impact	0.38	0.85	16.18	8.12	0.56	P	0.71	disease_causing	0.94	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11491	11491	A	T	MI.17860	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	732	244	M	I	atA/atT	5.78	0.89	0	benign	0.03	neutral	0.7	neutral	4.65	neutral	1.76	neutral	-2.28	neutral_impact	-0.1	0.65	neutral	0.95	neutral	2.30	18.17	deleterious	0.17	0.45	0.66	disease	0.25	neutral	0.34	neutral	0.57	disease	1	0.25	neutral	0.84	deleterious	-6	neutral	0.65	deleterious	0.7	medium_impact	0.41	medium_impact	-1.23	low_impact	0.43	0.8	8.93	21.34	0.5	N	0.34	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11491	11491	A	C	MI.17861	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	732	244	M	I	atA/atC	5.78	0.89	0	benign	0.03	neutral	0.7	neutral	4.65	neutral	1.76	neutral	-2.28	neutral_impact	-0.1	0.65	neutral	0.95	neutral	2.24	17.75	deleterious	0.17	0.45	0.66	disease	0.25	neutral	0.34	neutral	0.57	disease	1	0.25	neutral	0.84	deleterious	-6	neutral	0.65	deleterious	0.7	medium_impact	0.41	medium_impact	-1.23	low_impact	0.43	0.8	8.93	21.34	0.49	N	0.34	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11492	11492	C	G	MI.17862	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	733	245	R	G	Cgc/Ggc	-0.66	0.04	0	possibly_damaging	0.72	deleterious	0	neutral	4.19	deleterious	-5.95	deleterious	-6.06	high_impact	4.25	0.46	damaging	0.4	neutral	4.24	23.90	deleterious	0.02	0.35	0.41	neutral	0.73	disease	0.8	disease	0.7	disease	4	1	deleterious	0.14	neutral	5	deleterious	0.74	deleterious	-1.1	low_impact	-1.48	low_impact	3.08	high_impact	0.14	0.8	47.06	9.4	0.53	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11492	11492	C	T	MI.17863	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	733	245	R	C	Cgc/Tgc	-0.66	0.04	0	probably_damaging	0.98	deleterious	0	neutral	4.16	deleterious	-8.01	deleterious	-6.92	high_impact	4.05	0.46	damaging	0.21	damaging	5.04	25.20	deleterious	0.04	0.35	0.67	disease	0.84	disease	0.83	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.31	low_impact	-1.48	low_impact	2.88	high_impact	0.49	0.8	47.06	9.4	0.51	N	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11492	11492	C	A	MI.17864	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	733	245	R	S	Cgc/Agc	-0.66	0.04	0	possibly_damaging	0.76	deleterious	0	neutral	4.28	deleterious	-4.91	deleterious	-5.2	high_impact	4.25	0.49	damaging	0.43	neutral	4.60	24.40	deleterious	0.03	0.35	0.42	neutral	0.81	disease	0.79	disease	0.71	disease	4	1	deleterious	0.12	neutral	5	deleterious	0.76	deleterious	-1.19	low_impact	-1.48	low_impact	3.08	high_impact	0.20	0.8	47.06	9.4	0.56	P	0.81	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11493	11493	G	C	MI.17865	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	734	245	R	P	cGc/cCc	1.41	0.68	0	probably_damaging	0.95	deleterious	0	neutral	4.18	deleterious	-6.59	deleterious	-6.06	high_impact	4.25	0.45	damaging	0.29	neutral	4.30	24.00	deleterious	0.02	0.35	0.73	disease	0.87	disease	0.87	disease	0.76	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.84	deleterious	-1.92	low_impact	-1.48	low_impact	3.08	high_impact	0.11	0.8	47.06	9.4	0.6	P	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11493	11493	G	T	MI.17866	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	734	245	R	L	cGc/cTc	1.41	0.68	0	possibly_damaging	0.64	deleterious	0.01	neutral	4.2	deleterious	-4.72	deleterious	-6.06	high_impact	3.63	0.47	damaging	0.34	neutral	4.36	24.10	deleterious	0.02	0.35	0.73	disease	0.91	disease	0.79	disease	0.75	disease	5	0.99	deleterious	0.19	neutral	5	deleterious	0.83	deleterious	-0.95	medium_impact	-0.92	medium_impact	2.47	high_impact	0.07	0.8	47.06	9.4	0.53	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11493	11493	G	A	MI.17867	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	734	245	R	H	cGc/cAc	1.41	0.68	0	probably_damaging	0.95	deleterious	0.01	neutral	4.21	deleterious	-6.36	deleterious	-4.33	high_impact	4.25	0.44	damaging	0.21	damaging	4.57	24.40	deleterious	0.06	0.35	0.42	neutral	0.81	disease	0.82	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-1.92	low_impact	-0.92	medium_impact	3.08	high_impact	0.67	0.85	47.06	9.4	0.64	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	COSM1155511	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11495	11495	C	G	MI.17868	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	736	246	L	V	Ctc/Gtc	-2.5	0	0	benign	0.4	neutral	0.84	neutral	4.46	neutral	-0.25	neutral	0.4	neutral_impact	0.45	0.75	neutral	0.97	neutral	2.27	17.97	deleterious	0.28	0.45	0.38	neutral	0.24	neutral	0.19	neutral	0.45	neutral	1	0.29	neutral	0.72	deleterious	-6	neutral	0.69	deleterious	-0.55	medium_impact	0.61	medium_impact	-0.68	medium_impact	0.56	0.8	20.48	25.11	0.37	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11495	11495	C	T	MI.17869	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	736	246	L	F	Ctc/Ttc	-2.5	0	0	benign	0.11	neutral	0.43	neutral	4.41	neutral	-0.17	neutral	-1.88	neutral_impact	0.55	0.75	neutral	0.77	neutral	4.06	23.70	deleterious	0.23	0.45	0.75	disease	0.49	neutral	0.37	neutral	0.45	neutral	1	0.5	neutral	0.66	deleterious	-6	neutral	0.78	deleterious	0.14	medium_impact	0.13	medium_impact	-0.58	medium_impact	0.50	0.8	20.48	25.11	0.33	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8527	8527	A	C	MI.1787	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	162	54	K	N	aaA/aaC	2.21	1	0	probably_damaging	0.99	neutral	0.44	neutral	1.69	deleterious	-5.5	deleterious	-4.62	high_impact	3.52	0.98	neutral	0.45	neutral	3.93	23.50	deleterious	0.37793802	0.85	0.73	disease	0.66	disease	0.68	disease	0.63	disease	3	0.99	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-2.65	low_impact	0.23	medium_impact	1.92	medium_impact	0.38	0.85	16.18	8.12	0.54	P	0.71	disease_causing	0.94	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11495	11495	C	A	MI.17870	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	736	246	L	I	Ctc/Atc	-2.5	0	0	benign	0.09	neutral	1	neutral	4.4	neutral	-0.53	neutral	1.04	neutral_impact	-0.74	0.72	neutral	0.97	neutral	1.43	12.94	neutral	0.3	0.45	0.35	neutral	0.05	neutral	0.12	neutral	0.21	neutral	6	0.09	neutral	0.96	deleterious	-6	neutral	0.66	deleterious	0.23	medium_impact	1.88	high_impact	-1.86	low_impact	0.54	0.8	20.48	25.11	0.41	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11496	11496	T	A	MI.17871	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	737	246	L	H	cTc/cAc	-0.2	0	0	probably_damaging	0.98	deleterious	0	neutral	4.26	deleterious	-4.8	deleterious	-4.31	medium_impact	2.98	0.72	neutral	0.57	neutral	4.20	23.90	deleterious	0.04	0.35	0.4	neutral	0.65	disease	0.61	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.74	deleterious	-2.31	low_impact	-1.48	low_impact	1.82	medium_impact	0.23	0.8	20.48	25.11	0.39	N	0.82	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11496	11496	T	C	MI.17872	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	737	246	L	P	cTc/cCc	-0.2	0	0	probably_damaging	0.96	deleterious	0	neutral	4.26	deleterious	-4.74	deleterious	-4.26	medium_impact	2.63	0.63	neutral	0.44	neutral	3.97	23.60	deleterious	0.02	0.35	0.62	disease	0.87	disease	0.66	disease	0.79	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.86	deleterious	-2.01	low_impact	-1.48	low_impact	1.48	medium_impact	0.22	0.8	20.48	25.11	0.31	N	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11496	11496	T	G	MI.17873	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	737	246	L	R	cTc/cGc	-0.2	0	0	probably_damaging	0.93	deleterious	0.04	neutral	4.26	deleterious	-3.19	deleterious	-4.11	medium_impact	2.98	0.69	neutral	0.51	neutral	4.26	23.90	deleterious	0.04	0.35	0.38	neutral	0.88	disease	0.66	disease	0.79	disease	6	0.99	deleterious	0.06	neutral	5	deleterious	0.81	deleterious	-1.77	low_impact	-0.57	medium_impact	1.82	medium_impact	0.15	0.8	20.48	25.11	0.39	N	0.91	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11498	11498	A	C	MI.17874	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	739	247	T	P	Aca/Cca	-8.72	0	0	possibly_damaging	0.72	neutral	0.16	neutral	4.53	neutral	-2.99	deleterious	-3.02	medium_impact	2.6	0.65	neutral	0.34	neutral	1.83	15.15	deleterious	0.03	0.35	0.39	neutral	0.85	disease	0.71	disease	0.74	disease	5	0.87	neutral	0.22	neutral	0	NA	0.54	deleterious	-1.1	low_impact	-0.2	medium_impact	1.45	medium_impact	0.39	0.8	25.05	20.69	0.33	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11498	11498	A	G	MI.17875	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	739	247	T	A	Aca/Gca	-8.72	0	0	benign	0.01	neutral	0.47	neutral	4.59	neutral	-0.8	neutral	-1.81	low_impact	1.28	0.77	neutral	0.74	neutral	0.52	7.55	deleterious	0.2	0.45	0.61	disease	0.5	neutral	0.45	neutral	0.49	neutral	0	0.52	neutral	0.73	deleterious	-6	neutral	0.22	neutral	1.16	medium_impact	0.17	medium_impact	0.14	medium_impact	0.45	0.8	25.05	20.69	0.28	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11498	11498	A	T	MI.17876	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	739	247	T	S	Aca/Tca	-8.72	0	0	benign	0.25	neutral	0.84	neutral	4.69	neutral	0.43	neutral	-0.97	neutral_impact	-0.18	0.7	neutral	0.97	neutral	-0.18	1.24	neutral	0.38	0.5	0.51	disease	0.28	neutral	0.25	neutral	0.38	neutral	2	0.14	neutral	0.8	deleterious	-6	neutral	0.19	neutral	-0.27	medium_impact	0.61	medium_impact	-1.3	low_impact	0.73	0.85	25.05	20.69	0.3	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11499	11499	C	T	MI.17877	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	740	247	T	M	aCa/aTa	0.26	0	0	benign	0.06	neutral	0.99	neutral	4.57	neutral	-1.15	neutral	-1.52	low_impact	0.86	0.68	neutral	0.88	neutral	0.32	5.91	deleterious	0.1	0.4	0.8	disease	0.3	neutral	0.3	neutral	0.64	disease	3	0.03	neutral	0.97	deleterious	-6	neutral	0.20	neutral	0.41	medium_impact	1.32	medium_impact	-0.28	medium_impact	0.64	0.8	25.05	20.69	0.26	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11499	11499	C	A	MI.17878	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	740	247	T	K	aCa/aAa	0.26	0	0	possibly_damaging	0.45	neutral	0.34	neutral	4.55	neutral	-1.98	deleterious	-2.61	medium_impact	2.26	0.75	neutral	0.41	neutral	2.56	19.88	deleterious	0.05	0.35	0.57	disease	0.82	disease	0.62	disease	0.71	disease	4	0.62	neutral	0.45	neutral	0	NA	0.32	neutral	-0.64	medium_impact	0.04	medium_impact	1.11	medium_impact	0.52	0.8	25.05	20.69	0.31	N	0.78	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11501	11501	C	G	MI.17879	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	742	248	L	V	Ctc/Gtc	-4.35	0	0	benign	0.07	neutral	0.59	neutral	4.57	neutral	-1.44	neutral	0.31	low_impact	1.26	0.72	neutral	0.98	neutral	-0.45	0.30	neutral	0.35	0.5	0.44	neutral	0.28	neutral	0.2	neutral	0.44	neutral	1	0.34	neutral	0.76	deleterious	-6	neutral	0.15	neutral	0.34	medium_impact	0.29	medium_impact	0.12	medium_impact	0.61	0.8	21.79	16.34	0.4	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8528	8528	T	G	MI.1788	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	163	55	W	G	Tga/Gga	5.68	1	0	probably_damaging	0.98	neutral	0.34	neutral	-0.53	deleterious	-11.1	deleterious	-12.02	high_impact	3.7	0.84	neutral	0.1	damaging	3.96	23.60	deleterious	0.13200123	0.85	0.85	disease	0.71	disease	0.81	disease	0.76	disease	5	0.98	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-2.36	low_impact	0.13	medium_impact	2.07	high_impact	0.06	0.85	19.12	8.82	0.64	P	0.93	disease_causing	0.98	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11501	11501	C	T	MI.17880	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	742	248	L	F	Ctc/Ttc	-4.35	0	0	benign	0.38	neutral	0.7	neutral	4.56	neutral	-1.43	neutral	-1.68	low_impact	1.38	0.78	neutral	0.88	neutral	2.26	17.90	deleterious	0.23	0.45	0.4	neutral	0.4	neutral	0.19	neutral	0.45	neutral	1	0.29	neutral	0.66	deleterious	-6	neutral	0.43	neutral	-0.52	medium_impact	0.41	medium_impact	0.24	medium_impact	0.54	0.8	21.79	16.34	0.35	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11501	11501	C	A	MI.17881	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	742	248	L	I	Ctc/Atc	-4.35	0	0	benign	0.01	neutral	0.65	neutral	4.62	neutral	-1.62	neutral	0.42	low_impact	0.86	0.75	neutral	1	neutral	-0.54	0.18	neutral	0.31	0.45	0.43	neutral	0.17	neutral	0.17	neutral	0.31	neutral	4	0.33	neutral	0.82	deleterious	-6	neutral	0.11	neutral	1.16	medium_impact	0.35	medium_impact	-0.28	medium_impact	0.48	0.8	21.79	16.34	0.45	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11502	11502	T	G	MI.17882	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	743	248	L	R	cTc/cGc	-3.42	0	0	possibly_damaging	0.47	neutral	0.33	neutral	4.56	deleterious	-4.55	deleterious	-2.66	medium_impact	2.52	0.72	neutral	0.51	neutral	3.95	23.60	deleterious	0.02	0.35	0.35	neutral	0.82	disease	0.52	disease	0.73	disease	5	0.63	neutral	0.43	neutral	0	NA	0.63	deleterious	-0.67	medium_impact	0.03	medium_impact	1.37	medium_impact	0.15	0.8	21.79	16.34	0.35	N	0.26	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11502	11502	T	A	MI.17883	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	743	248	L	H	cTc/cAc	-3.42	0	0	possibly_damaging	0.79	neutral	0.53	neutral	4.53	deleterious	-4.79	deleterious	-3	medium_impact	2.87	0.78	neutral	0.58	neutral	4.11	23.80	deleterious	0.04	0.35	0.41	neutral	0.61	disease	0.29	neutral	0.46	neutral	1	0.76	neutral	0.37	neutral	0	NA	0.64	deleterious	-1.26	low_impact	0.23	medium_impact	1.71	medium_impact	0.12	0.8	21.79	16.34	0.28	N	0.31	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11502	11502	T	C	MI.17884	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	743	248	L	P	cTc/cCc	-3.42	0	0	benign	0.01	neutral	0.27	neutral	4.63	neutral	-0.82	neutral	-2.08	neutral_impact	-0.4	0.77	neutral	0.92	neutral	0.73	9.05	deleterious	0.02	0.35	0.7	disease	0.61	disease	0.38	neutral	0.49	neutral	0	0.73	neutral	0.63	deleterious	-6	neutral	0.25	neutral	1.16	medium_impact	-0.04	medium_impact	-1.52	low_impact	0.11	0.8	21.79	16.34	0.31	N	0.01	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11504	11504	A	G	MI.17885	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	745	249	I	V	Att/Gtt	-10.33	0	0	benign	0.05	neutral	0.43	neutral	4.56	neutral	-0.73	neutral	-0.5	low_impact	1.49	0.74	neutral	0.93	neutral	-0.36	0.49	neutral	0.58	0.65	0.76	disease	0.28	neutral	0.35	neutral	0.58	disease	2	0.53	neutral	0.69	deleterious	-6	neutral	0.16	neutral	0.48	medium_impact	0.13	medium_impact	0.35	medium_impact	0.28	0.8	9.8	13.79	0.4	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11504	11504	A	T	MI.17886	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	745	249	I	F	Att/Ttt	-10.33	0	0	possibly_damaging	0.83	neutral	0.6	neutral	4.48	neutral	-1.97	neutral	-1.33	neutral_impact	0.56	0.77	neutral	0.97	neutral	1.98	16.12	deleterious	0.2	0.45	0.63	disease	0.5	neutral	0.34	neutral	0.49	neutral	0	0.8	neutral	0.39	neutral	-3	neutral	0.56	deleterious	-1.37	low_impact	0.3	medium_impact	-0.57	medium_impact	0.49	0.8	9.8	13.79	0.32	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11504	11504	A	C	MI.17887	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	745	249	I	L	Att/Ctt	-10.33	0	0	benign	0.05	neutral	1	neutral	4.84	neutral	1.01	neutral	0.07	neutral_impact	0.2	0.74	neutral	0.97	neutral	-0.02	2.39	deleterious	0.24	0.45	0.52	disease	0.32	neutral	0.23	neutral	0.37	neutral	3	0.05	neutral	0.98	deleterious	-6	neutral	0.17	neutral	0.48	medium_impact	1.88	high_impact	-0.93	medium_impact	0.49	0.8	9.8	13.79	0.3	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11505	11505	T	C	MI.17888	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	746	249	I	T	aTt/aCt	-1.12	0	0	possibly_damaging	0.75	neutral	0.38	neutral	4.48	neutral	-2.01	deleterious	-2.62	low_impact	0.82	0.7	neutral	0.8	neutral	0.32	5.86	deleterious	0.17	0.45	0.48	neutral	0.48	neutral	0.38	neutral	0.44	neutral	1	0.77	neutral	0.32	neutral	-3	neutral	0.39	neutral	-1.17	low_impact	0.08	medium_impact	-0.32	medium_impact	0.12	0.8	9.8	13.79	0.32	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11505	11505	T	G	MI.17889	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	746	249	I	S	aTt/aGt	-1.12	0	0	probably_damaging	0.9	neutral	0.38	neutral	4.49	neutral	-1.83	deleterious	-3.24	low_impact	1.62	0.79	neutral	0.77	neutral	2.73	21.00	deleterious	0.04	0.35	0.7	disease	0.71	disease	0.65	disease	0.66	disease	3	0.91	neutral	0.24	neutral	-2	neutral	0.51	deleterious	-1.61	low_impact	0.08	medium_impact	0.48	medium_impact	0.09	0.8	9.8	13.79	0.27	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8528	8528	T	C	MI.1789	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	163	55	W	R	Tga/Cga	5.68	1	0	probably_damaging	1	neutral	0.31	neutral	-0.53	deleterious	-11.02	deleterious	-12.74	high_impact	3.7	0.85	neutral	0.06	damaging	3.65	23.20	deleterious	0.15055088	0.85	0.89	disease	0.74	disease	0.84	disease	0.77	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.1	medium_impact	2.07	high_impact	0.08	0.85	19.12	8.82	0.58	P	0.97	disease_causing_automatic	0.95	0.25	rs387906422	Pathogenic	Cardiomyopathy,_infantile_hypertrophic	24679	MedGen:C2748884,OMIM:500006	.	.	.	.	T8528C	Infantile cardiomyopathy	+	+	Cfrm	3	P	P	P	damaging
chrM	11505	11505	T	A	MI.17890	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	746	249	I	N	aTt/aAt	-1.12	0	0	probably_damaging	0.96	neutral	0.08	neutral	4.44	deleterious	-3.5	deleterious	-4.11	medium_impact	2.06	0.77	neutral	0.47	neutral	4.32	24.00	deleterious	0.1	0.4	0.64	disease	0.75	disease	0.66	disease	0.71	disease	4	0.99	deleterious	0.06	neutral	1	deleterious	0.71	deleterious	-2.01	low_impact	-0.39	medium_impact	0.91	medium_impact	0.08	0.8	9.8	13.79	0.3	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11506	11506	T	G	MI.17891	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	747	249	I	M	atT/atG	3.02	0.71	0	probably_damaging	0.9	neutral	0.72	neutral	4.48	neutral	-1.93	neutral	0.11	neutral_impact	0.46	0.71	neutral	0.98	neutral	0.60	8.13	deleterious	0.35	0.5	0.73	disease	0.2	neutral	0.28	neutral	0.51	disease	0	0.89	neutral	0.41	neutral	-2	neutral	0.56	deleterious	-1.61	low_impact	0.43	medium_impact	-0.67	medium_impact	0.56	0.8	9.8	13.79	0.41	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11506	11506	T	A	MI.17892	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	747	249	I	M	atT/atA	3.02	0.71	0	probably_damaging	0.9	neutral	0.72	neutral	4.48	neutral	-1.93	neutral	0.11	neutral_impact	0.46	0.71	neutral	0.98	neutral	0.95	10.35	neutral	0.35	0.5	0.73	disease	0.2	neutral	0.28	neutral	0.51	disease	0	0.89	neutral	0.41	neutral	-2	neutral	0.56	deleterious	-1.61	low_impact	0.43	medium_impact	-0.67	medium_impact	0.56	0.8	9.8	13.79	0.41	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11507	11507	C	T	MI.17893	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	748	250	L	F	Ctc/Ttc	-7.57	0	0	probably_damaging	1	neutral	0.44	neutral	4.63	neutral	-0.76	deleterious	-3.14	low_impact	1.34	0.71	neutral	0.23	damaging	4.03	23.60	deleterious	0.21	0.45	0.87	disease	0.43	neutral	0.31	neutral	0.65	disease	3	1	deleterious	0.22	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	0.14	medium_impact	0.2	medium_impact	0.42	0.8	15.69	22.83	0.26	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11507	11507	C	A	MI.17894	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	748	250	L	I	Ctc/Atc	-7.57	0	0	probably_damaging	1	neutral	0.17	neutral	4.61	neutral	-1.59	neutral	-1.46	low_impact	1.57	0.78	neutral	0.31	neutral	4.10	23.70	deleterious	0.35	0.5	0.58	disease	0.64	disease	0.27	neutral	0.47	neutral	1	1	deleterious	0.09	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	-0.18	medium_impact	0.43	medium_impact	0.37	0.8	15.69	22.83	0.32	N	0.17	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11507	11507	C	G	MI.17895	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	748	250	L	V	Ctc/Gtc	-7.57	0	0	probably_damaging	1	neutral	0.07	neutral	4.53	neutral	-1.62	neutral	-2.2	medium_impact	2.4	0.72	neutral	0.23	damaging	3.48	23.10	deleterious	0.36	0.5	0.69	disease	0.66	disease	0.32	neutral	0.47	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.43	medium_impact	1.25	medium_impact	0.43	0.8	15.69	22.83	0.34	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11508	11508	T	G	MI.17896	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	749	250	L	R	cTc/cGc	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-4.93	deleterious	-4.77	high_impact	4.07	0.59	damaging	0.11	damaging	4.19	23.90	deleterious	0.02	0.35	0.43	neutral	0.91	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.9	high_impact	0.06	0.8	15.69	22.83	0.37	N	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11508	11508	T	A	MI.17897	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	749	250	L	H	cTc/cAc	-0.2	0	0	probably_damaging	1	deleterious	0.01	neutral	4.44	deleterious	-5.3	deleterious	-5.58	high_impact	4.07	0.64	neutral	0.1	damaging	4.07	23.70	deleterious	0.05	0.35	0.65	disease	0.82	disease	0.69	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	2.9	high_impact	0.12	0.8	15.69	22.83	0.31	N	0.86	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11508	11508	T	C	MI.17898	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	749	250	L	P	cTc/cCc	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-4.96	deleterious	-5.54	high_impact	3.73	0.56	damaging	0.13	damaging	3.94	23.50	deleterious	0.02	0.35	0.53	disease	0.87	disease	0.73	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.56	high_impact	0.12	0.8	15.69	22.83	0.32	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11510	11510	A	C	MI.17899	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	751	251	N	H	Aac/Cac	-11.71	0	0	possibly_damaging	0.89	neutral	0.54	neutral	4.58	neutral	-1.19	neutral	-1.94	medium_impact	1.95	0.79	neutral	0.86	neutral	2.79	21.30	deleterious	0.33	0.5	0.63	disease	0.51	disease	0.33	neutral	0.5	neutral	0	0.87	neutral	0.33	neutral	0	NA	0.51	deleterious	-1.57	low_impact	0.24	medium_impact	0.8	medium_impact	0.23	0.8	28.32	21.7	0.28	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8609	8609	C	A	MI.179	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	83	28	P	H	cCt/cAt	-0.57	0	0	possibly_damaging	0.9	neutral	0.09	neutral	4.39	neutral	0.05	neutral	-0.22	neutral_impact	0.46	0.87	neutral	0.43	neutral	2.05	16.56	deleterious	0.3	0.65	0.7	disease	0.29	neutral	0.49	neutral	0.61	disease	2	0.97	neutral	0.1	neutral	-3	neutral	0.69	deleterious	-1.66	low_impact	-0.28	medium_impact	-0.7	medium_impact	0.59	0.9	31.86	20.94	0.45	N	0.53	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8529	8529	G	T	MI.1790	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	164	55	W	L	tGa/tTa	7.53	1	0	probably_damaging	0.98	neutral	0.69	neutral	-0.52	deleterious	-8.9	deleterious	-12.02	high_impact	3.7	0.84	neutral	0.06	damaging	4.28	24.00	deleterious	0.09988831	0.85	0.79	disease	0.71	disease	0.8	disease	0.73	disease	5	0.98	deleterious	0.36	neutral	2	deleterious	0.86	deleterious	-2.36	low_impact	0.49	medium_impact	2.07	high_impact	0.06	0.85	19.12	8.82	0.58	P	0.96	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11510	11510	A	G	MI.17900	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	751	251	N	D	Aac/Gac	-11.71	0	0	benign	0.01	neutral	0.3	neutral	4.6	neutral	-0.64	neutral	0.39	low_impact	1.72	0.74	neutral	0.98	neutral	-0.81	0.04	neutral	0.46	0.55	0.59	disease	0.32	neutral	0.34	neutral	0.6	disease	2	0.69	neutral	0.65	deleterious	-6	neutral	0.14	neutral	1.16	medium_impact	0	medium_impact	0.58	medium_impact	0.29	0.8	28.32	21.7	0.47	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11510	11510	A	T	MI.17901	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	751	251	N	Y	Aac/Tac	-11.71	0	0	possibly_damaging	0.89	neutral	1	neutral	4.54	neutral	-2.84	deleterious	-3.74	low_impact	1.42	0.8	neutral	0.69	neutral	3.35	22.90	deleterious	0.13	0.4	0.4	neutral	0.61	disease	0.38	neutral	0.47	neutral	1	0.89	neutral	0.56	deleterious	-3	neutral	0.53	deleterious	-1.57	low_impact	1.88	high_impact	0.28	medium_impact	0.17	0.8	28.32	21.7	0.22	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11511	11511	A	G	MI.17902	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	752	251	N	S	aAc/aGc	0.03	0	0	benign	0.04	neutral	0.49	neutral	4.7	neutral	0.6	neutral	-1.38	low_impact	0.83	0.73	neutral	0.97	neutral	0.39	6.57	deleterious	0.42	0.5	0.6	disease	0.35	neutral	0.26	neutral	0.61	disease	2	0.47	neutral	0.73	deleterious	-6	neutral	0.15	neutral	0.58	medium_impact	0.19	medium_impact	-0.31	medium_impact	0.27	0.8	28.32	21.7	0.39	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11511	11511	A	C	MI.17903	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	752	251	N	T	aAc/aCc	0.03	0	0	benign	0.32	neutral	0.46	neutral	4.59	neutral	-0.99	neutral	-1.92	low_impact	1.3	0.68	neutral	0.84	neutral	0.49	7.37	deleterious	0.27	0.45	0.71	disease	0.32	neutral	0.38	neutral	0.64	disease	3	0.45	neutral	0.57	deleterious	-6	neutral	0.19	neutral	-0.41	medium_impact	0.16	medium_impact	0.16	medium_impact	0.37	0.8	28.32	21.7	0.39	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11511	11511	A	T	MI.17904	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	752	251	N	I	aAc/aTc	0.03	0	0	possibly_damaging	0.85	neutral	0.42	neutral	4.58	neutral	-1.12	deleterious	-4.2	low_impact	1.46	0.79	neutral	0.63	neutral	2.79	21.30	deleterious	0.16	0.45	0.67	disease	0.7	disease	0.39	neutral	0.54	disease	1	0.85	neutral	0.29	neutral	-3	neutral	0.34	neutral	-1.43	low_impact	0.12	medium_impact	0.32	medium_impact	0.12	0.8	28.32	21.7	0.27	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11512	11512	C	A	MI.17905	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	753	251	N	K	aaC/aaA	0.03	0	0	possibly_damaging	0.44	neutral	0.36	neutral	4.64	neutral	-0.02	neutral	-2.02	low_impact	1.46	0.77	neutral	0.5	neutral	2.60	20.20	deleterious	0.4	0.5	0.53	disease	0.65	disease	0.5	neutral	0.49	neutral	0	0.59	neutral	0.46	neutral	-3	neutral	0.23	neutral	-0.62	medium_impact	0.06	medium_impact	0.32	medium_impact	0.31	0.8	28.32	21.7	0.3	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11512	11512	C	G	MI.17906	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	753	251	N	K	aaC/aaG	0.03	0	0	possibly_damaging	0.44	neutral	0.36	neutral	4.64	neutral	-0.02	neutral	-2.02	low_impact	1.46	0.77	neutral	0.5	neutral	2.16	17.25	deleterious	0.4	0.5	0.53	disease	0.65	disease	0.5	neutral	0.49	neutral	0	0.59	neutral	0.46	neutral	-3	neutral	0.23	neutral	-0.62	medium_impact	0.06	medium_impact	0.32	medium_impact	0.31	0.8	28.32	21.7	0.3	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11513	11513	C	G	MI.17907	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	754	252	P	A	Ccc/Gcc	-5.5	0	0	probably_damaging	0.92	neutral	0.51	neutral	1.98	neutral	-2.14	deleterious	-6.79	medium_impact	2.94	0.69	neutral	0.21	damaging	3.13	22.60	deleterious	0.38	0.5	0.37	neutral	0.61	disease	0.33	neutral	0.48	neutral	0	0.92	neutral	0.3	neutral	1	deleterious	0.72	deleterious	-1.71	low_impact	0.21	medium_impact	1.78	medium_impact	0.53	0.8	39.43	8.08	0.29	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11513	11513	C	T	MI.17908	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	754	252	P	S	Ccc/Tcc	-5.5	0	0	probably_damaging	0.98	neutral	0.45	neutral	1.96	neutral	-2.7	deleterious	-6.78	medium_impact	1.96	0.76	neutral	0.21	damaging	3.87	23.50	deleterious	0.38	0.5	0.49	neutral	0.72	disease	0.19	neutral	0.45	neutral	1	0.98	deleterious	0.24	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	0.15	medium_impact	0.81	medium_impact	0.11	0.8	39.43	8.08	0.32	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11513	11513	C	A	MI.17909	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	754	252	P	T	Ccc/Acc	-5.5	0	0	probably_damaging	0.98	neutral	0.43	neutral	1.94	deleterious	-3.25	deleterious	-6.81	low_impact	1.68	0.71	neutral	0.25	damaging	3.89	23.50	deleterious	0.32	0.5	0.62	disease	0.74	disease	0.17	neutral	0.48	neutral	0	0.98	neutral	0.23	neutral	-2	neutral	0.77	deleterious	-2.31	low_impact	0.13	medium_impact	0.54	medium_impact	0.34	0.8	39.43	8.08	0.34	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8529	8529	G	C	MI.1791	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	164	55	W	S	tGa/tCa	7.53	1	0	probably_damaging	0.99	neutral	0.4	neutral	-0.53	deleterious	-10.54	deleterious	-12.78	high_impact	3.7	0.83	neutral	0.07	damaging	4.06	23.70	deleterious	0.11512998	0.85	0.88	disease	0.8	disease	0.8	disease	0.79	disease	6	0.99	deleterious	0.21	neutral	2	deleterious	0.90	deleterious	-2.65	low_impact	0.19	medium_impact	2.07	high_impact	0.03	0.85	19.12	8.82	0.59	P	0.95	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11514	11514	C	G	MI.17910	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	755	252	P	R	cCc/cGc	3.48	0.71	0	probably_damaging	0.99	neutral	0.34	neutral	1.92	deleterious	-3.47	deleterious	-7.71	medium_impact	3.29	0.62	neutral	0.14	damaging	3.70	23.30	deleterious	0.09	0.35	0.66	disease	0.9	disease	0.49	neutral	0.7	disease	4	0.99	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-2.59	low_impact	0.04	medium_impact	2.13	high_impact	0.24	0.8	39.43	8.08	0.42	N	0.58	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11514	11514	C	T	MI.17911	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	755	252	P	L	cCc/cTc	3.48	0.71	0	benign	0.38	neutral	0.67	neutral	1.92	deleterious	-3.51	deleterious	-8.52	low_impact	1.88	0.67	neutral	0.15	damaging	4.45	24.20	deleterious	0.21	0.45	0.53	disease	0.85	disease	0.36	neutral	0.53	disease	1	0.3	neutral	0.65	deleterious	-6	neutral	0.77	deleterious	-0.52	medium_impact	0.37	medium_impact	0.73	medium_impact	0.54	0.8	39.43	8.08	0.33	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11514	11514	C	A	MI.17912	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	755	252	P	H	cCc/cAc	3.48	0.71	0	probably_damaging	1	neutral	0.51	neutral	1.89	deleterious	-4.1	deleterious	-7.73	medium_impact	3.09	0.7	neutral	0.14	damaging	4.07	23.70	deleterious	0.14	0.4	0.83	disease	0.84	disease	0.32	neutral	0.71	disease	4	0.99	deleterious	0.26	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.21	medium_impact	1.93	medium_impact	0.12	0.8	39.43	8.08	0.36	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11516	11516	C	A	MI.17913	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	757	253	L	M	Ctg/Atg	-14.01	0	0	probably_damaging	0.96	neutral	0.21	neutral	4.62	neutral	-0.63	neutral	-0.8	low_impact	1.31	0.76	neutral	0.97	neutral	2.66	20.60	deleterious	0.31	0.45	0.74	disease	0.29	neutral	0.22	neutral	0.61	disease	2	0.97	neutral	0.13	neutral	-2	neutral	0.72	deleterious	-2.01	low_impact	-0.12	medium_impact	0.17	medium_impact	0.49	0.8	16.56	14.33	0.47	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11516	11516	C	G	MI.17914	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	757	253	L	V	Ctg/Gtg	-14.01	0	0	possibly_damaging	0.52	neutral	0.41	neutral	4.67	neutral	0.54	neutral	-1.13	low_impact	1.08	0.8	neutral	0.95	neutral	2.40	18.81	deleterious	0.27	0.45	0.65	disease	0.43	neutral	0.36	neutral	0.61	disease	2	0.58	neutral	0.45	neutral	-3	neutral	0.72	deleterious	-0.75	medium_impact	0.11	medium_impact	-0.06	medium_impact	0.28	0.8	16.56	14.33	0.35	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11517	11517	T	A	MI.17915	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	758	253	L	Q	cTg/cAg	-13.32	0	0	probably_damaging	0.97	neutral	0.23	neutral	4.64	neutral	-0.03	deleterious	-3.81	low_impact	1.08	0.82	neutral	0.87	neutral	4.20	23.90	deleterious	0.14	0.4	0.9	disease	0.71	disease	0.26	neutral	0.61	disease	2	0.98	neutral	0.13	neutral	-2	neutral	0.81	deleterious	-2.14	low_impact	-0.09	medium_impact	-0.06	medium_impact	0.20	0.8	16.56	14.33	0.34	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11517	11517	T	C	MI.17916	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	758	253	L	P	cTg/cCg	-13.32	0	0	probably_damaging	0.97	neutral	0.15	neutral	4.6	neutral	-1.47	deleterious	-4.52	medium_impact	1.94	0.72	neutral	0.69	neutral	3.89	23.50	deleterious	0.1	0.4	0.93	disease	0.81	disease	0.17	neutral	0.69	disease	4	0.98	deleterious	0.09	neutral	1	deleterious	0.87	deleterious	-2.14	low_impact	-0.22	medium_impact	0.79	medium_impact	0.23	0.8	16.56	14.33	0.42	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11517	11517	T	G	MI.17917	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	758	253	L	R	cTg/cGg	-13.32	0	0	probably_damaging	0.96	neutral	0.22	neutral	4.64	neutral	-0.18	deleterious	-3.98	medium_impact	3.29	0.69	neutral	0.45	neutral	4.23	23.90	deleterious	0.1	0.4	0.91	disease	0.86	disease	0.58	disease	0.76	disease	5	0.97	neutral	0.13	neutral	1	deleterious	0.87	deleterious	-2.01	low_impact	-0.11	medium_impact	2.13	high_impact	0.16	0.8	16.56	14.33	0.37	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11519	11519	A	C	MI.17918	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	760	254	T	P	Aca/Cca	-5.73	0	0	probably_damaging	0.98	neutral	0.18	neutral	4.6	neutral	-0.88	deleterious	-4.38	low_impact	1.7	0.7	neutral	0.53	neutral	3.52	23.10	deleterious	0.09	0.35	0.56	disease	0.83	disease	0.41	neutral	0.55	disease	1	0.99	deleterious	0.1	neutral	-2	neutral	0.82	deleterious	-2.31	low_impact	-0.17	medium_impact	0.56	medium_impact	0.17	0.8	19.61	9.78	0.32	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11519	11519	A	T	MI.17919	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	760	254	T	S	Aca/Tca	-5.73	0	0	possibly_damaging	0.86	neutral	1	neutral	4.75	neutral	-0.14	neutral	-2.06	neutral_impact	0.74	0.65	neutral	0.64	neutral	1.98	16.09	deleterious	0.4	0.5	0.25	neutral	0.29	neutral	0.21	neutral	0.44	neutral	1	0.85	neutral	0.57	deleterious	-3	neutral	0.68	deleterious	-1.46	low_impact	1.88	high_impact	-0.39	medium_impact	0.38	0.8	19.61	9.78	0.34	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8530	8530	A	C	MI.1792	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	165	55	W	C	tgA/tgC	7.3	1	0	probably_damaging	1	neutral	0.21	neutral	-0.53	deleterious	-12.01	deleterious	-12.04	high_impact	3.7	0.92	neutral	0.05	damaging	4.07	23.70	deleterious	0.12589835	0.85	0.94	disease	0.77	disease	0.83	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.03	medium_impact	2.07	high_impact	0.06	0.85	19.12	8.82	0.6	P	0.92	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11519	11519	A	G	MI.17920	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	760	254	T	A	Aca/Gca	-5.73	0	0	benign	0.22	neutral	0.52	neutral	4.69	neutral	0.77	deleterious	-3.36	low_impact	1.12	0.77	neutral	0.65	neutral	3.51	23.10	deleterious	0.29	0.45	0.22	neutral	0.48	neutral	0.41	neutral	0.46	neutral	1	0.37	neutral	0.65	deleterious	-6	neutral	0.70	deleterious	-0.2	medium_impact	0.22	medium_impact	-0.02	medium_impact	0.24	0.8	19.61	9.78	0.29	N	0.69	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11520	11520	C	A	MI.17921	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	761	254	T	K	aCa/aAa	0.03	0	0	probably_damaging	0.96	neutral	0.25	neutral	4.64	neutral	-1.36	deleterious	-4.11	low_impact	1.17	0.75	neutral	0.51	neutral	4.44	24.20	deleterious	0.1	0.4	0.6	disease	0.8	disease	0.57	disease	0.55	disease	1	0.97	neutral	0.15	neutral	-2	neutral	0.80	deleterious	-2.01	low_impact	-0.07	medium_impact	0.03	medium_impact	0.42	0.8	19.61	9.78	0.31	N	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11520	11520	C	T	MI.17922	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	761	254	T	M	aCa/aTa	0.03	0	0	probably_damaging	0.99	neutral	0.23	neutral	4.59	neutral	-2.66	deleterious	-4.24	low_impact	1.7	0.77	neutral	0.61	neutral	4.07	23.70	deleterious	0.16	0.45	0.52	disease	0.6	disease	0.25	neutral	0.46	neutral	1	0.99	deleterious	0.12	neutral	-2	neutral	0.74	deleterious	-2.59	low_impact	-0.09	medium_impact	0.56	medium_impact	0.48	0.8	19.61	9.78	0.35	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11522	11522	A	G	MI.17923	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	763	255	K	E	Aaa/Gaa	-2.96	0	0	benign	0.01	neutral	0.96	neutral	4.66	neutral	0.15	neutral	-0.73	neutral_impact	-0.26	0.83	neutral	0.95	neutral	2.67	20.60	deleterious	0.21	0.45	0.5	disease	0.6	disease	0.28	neutral	0.45	neutral	1	0.01	neutral	0.98	deleterious	-6	neutral	0.73	deleterious	1.16	medium_impact	0.98	medium_impact	-1.38	low_impact	0.33	0.8	24.4	15.88	0.19	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11522	11522	A	C	MI.17924	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	763	255	K	Q	Aaa/Caa	-2.96	0	0	benign	0.37	neutral	0.57	neutral	4.58	neutral	-0.95	neutral	-1.31	neutral_impact	0.5	0.8	neutral	0.79	neutral	3.45	23.00	deleterious	0.34	0.5	0.53	disease	0.52	disease	0.36	neutral	0.49	neutral	0	0.37	neutral	0.6	deleterious	-6	neutral	0.70	deleterious	-0.5	medium_impact	0.27	medium_impact	-0.63	medium_impact	0.23	0.8	24.4	15.88	0.23	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11523	11523	A	C	MI.17925	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	764	255	K	T	aAa/aCa	1.87	0	0	benign	0.34	neutral	0.6	neutral	4.6	neutral	-0.61	neutral	-2.33	neutral_impact	-0.78	0.75	neutral	0.96	neutral	2.49	19.38	deleterious	0.17	0.45	0.33	neutral	0.4	neutral	0.16	neutral	0.47	neutral	1	0.32	neutral	0.63	deleterious	-6	neutral	0.69	deleterious	-0.45	medium_impact	0.3	medium_impact	-1.9	low_impact	0.17	0.8	24.4	15.88	0.37	N	0.35	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11523	11523	A	T	MI.17926	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	764	255	K	M	aAa/aTa	1.87	0	0	probably_damaging	0.93	neutral	0.15	neutral	4.54	neutral	-2.46	deleterious	-2.97	neutral_impact	0.15	0.82	neutral	0.77	neutral	3.80	23.40	deleterious	0.14	0.4	0.31	neutral	0.48	neutral	0.22	neutral	0.44	neutral	1	0.96	neutral	0.11	neutral	-2	neutral	0.68	deleterious	-1.77	low_impact	-0.22	medium_impact	-0.98	medium_impact	0.15	0.8	24.4	15.88	0.37	N	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11524	11524	A	T	MI.17927	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	765	255	K	N	aaA/aaT	0.03	0	0	benign	0.02	neutral	0.59	neutral	4.69	neutral	0.5	neutral	-1.51	neutral_impact	-0.28	0.75	neutral	0.98	neutral	2.71	20.90	deleterious	0.51	0.6	0.31	neutral	0.44	neutral	0.25	neutral	0.46	neutral	1	0.38	neutral	0.79	deleterious	-6	neutral	0.69	deleterious	0.87	medium_impact	0.29	medium_impact	-1.4	low_impact	0.31	0.8	24.4	15.88	0.37	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11524	11524	A	C	MI.17928	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	765	255	K	N	aaA/aaC	0.03	0	0	benign	0.02	neutral	0.59	neutral	4.69	neutral	0.5	neutral	-1.51	neutral_impact	-0.28	0.75	neutral	0.98	neutral	2.69	20.70	deleterious	0.51	0.6	0.31	neutral	0.44	neutral	0.25	neutral	0.46	neutral	1	0.38	neutral	0.79	deleterious	-6	neutral	0.69	deleterious	0.87	medium_impact	0.29	medium_impact	-1.4	low_impact	0.31	0.8	24.4	15.88	0.37	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11525	11525	C	A	MI.17929	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	766	256	H	N	Cac/Aac	-2.5	0	0	benign	0.18	neutral	0.56	neutral	4.73	neutral	-0.17	neutral	0.25	neutral_impact	-0.56	0.75	neutral	0.94	neutral	2.56	19.88	deleterious	0.37	0.5	0.38	neutral	0.3	neutral	0.31	neutral	0.46	neutral	1	0.33	neutral	0.69	deleterious	-6	neutral	0.66	deleterious	-0.1	medium_impact	0.26	medium_impact	-1.68	low_impact	0.41	0.8	31.59	21.45	0.3	N	0.38	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8530	8530	A	T	MI.1793	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	165	55	W	C	tgA/tgT	7.3	1	0	probably_damaging	1	neutral	0.21	neutral	-0.53	deleterious	-12.01	deleterious	-12.04	high_impact	3.7	0.92	neutral	0.05	damaging	4.16	23.80	deleterious	0.12589835	0.85	0.94	disease	0.77	disease	0.83	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.03	medium_impact	2.07	high_impact	0.06	0.85	19.12	8.82	0.6	P	0.92	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11525	11525	C	G	MI.17930	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	766	256	H	D	Cac/Gac	-2.5	0	0	benign	0	neutral	0.3	neutral	4.73	neutral	0.35	neutral	-0.08	neutral_impact	0.08	0.72	neutral	0.8	neutral	2.37	18.65	deleterious	0.08	0.35	0.78	disease	0.45	neutral	0.4	neutral	0.64	disease	3	0.7	neutral	0.65	deleterious	-6	neutral	0.76	deleterious	2.1	high_impact	0	medium_impact	-1.05	low_impact	0.43	0.8	31.59	21.45	0.42	N	0.54	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11525	11525	C	T	MI.17931	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	766	256	H	Y	Cac/Tac	-2.5	0	0	benign	0	neutral	1	neutral	4.64	neutral	-0.49	neutral	-0.55	neutral_impact	-0.1	0.83	neutral	0.97	neutral	1.92	15.73	deleterious	0.23	0.45	0.39	neutral	0.34	neutral	0.26	neutral	0.46	neutral	1	0	neutral	1	deleterious	-6	neutral	0.69	deleterious	2.1	high_impact	1.88	high_impact	-1.23	low_impact	0.13	0.8	31.59	21.45	0.3	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11526	11526	A	G	MI.17932	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	767	256	H	R	cAc/cGc	-2.04	0	0	benign	0.18	neutral	0.39	neutral	4.67	neutral	-0.38	neutral	-0.5	low_impact	0.9	0.8	neutral	0.52	neutral	1.69	14.35	neutral	0.19	0.45	0.63	disease	0.54	disease	0.42	neutral	0.51	disease	0	0.53	neutral	0.61	deleterious	-6	neutral	0.76	deleterious	-0.1	medium_impact	0.09	medium_impact	-0.24	medium_impact	0.13	0.8	31.59	21.45	0.31	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11526	11526	A	T	MI.17933	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	767	256	H	L	cAc/cTc	-2.04	0	0	benign	0.07	neutral	0.75	neutral	4.77	neutral	-0.24	neutral	-1.43	neutral_impact	-0.14	0.78	neutral	0.85	neutral	2.33	18.37	deleterious	0.1	0.4	0.83	disease	0.52	disease	0.43	neutral	0.59	disease	2	0.15	neutral	0.84	deleterious	-6	neutral	0.71	deleterious	0.34	medium_impact	0.47	medium_impact	-1.26	low_impact	0.16	0.8	31.59	21.45	0.23	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11526	11526	A	C	MI.17934	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	767	256	H	P	cAc/cCc	-2.04	0	0	possibly_damaging	0.48	neutral	0.25	neutral	4.64	neutral	-1.32	neutral	-1.39	neutral_impact	0.08	0.72	neutral	0.73	neutral	2.07	16.66	deleterious	0.07	0.35	0.71	disease	0.77	disease	0.56	disease	0.74	disease	5	0.72	neutral	0.39	neutral	-3	neutral	0.83	deleterious	-0.69	medium_impact	-0.07	medium_impact	-1.05	low_impact	0.27	0.8	31.59	21.45	0.31	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11527	11527	C	G	MI.17935	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	768	256	H	Q	caC/caG	-4.12	0	0	benign	0.26	neutral	0.38	neutral	4.68	neutral	0.17	neutral	0.18	neutral_impact	0.34	0.79	neutral	0.9	neutral	2.13	17.04	deleterious	0.24	0.45	0.57	disease	0.27	neutral	0.32	neutral	0.56	disease	1	0.54	neutral	0.56	deleterious	-6	neutral	0.69	deleterious	-0.29	medium_impact	0.08	medium_impact	-0.79	medium_impact	0.42	0.8	31.59	21.45	0.37	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11527	11527	C	A	MI.17936	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	768	256	H	Q	caC/caA	-4.12	0	0	benign	0.26	neutral	0.38	neutral	4.68	neutral	0.17	neutral	0.18	neutral_impact	0.34	0.79	neutral	0.9	neutral	2.54	19.75	deleterious	0.24	0.45	0.57	disease	0.27	neutral	0.32	neutral	0.56	disease	1	0.54	neutral	0.56	deleterious	-6	neutral	0.69	deleterious	-0.29	medium_impact	0.08	medium_impact	-0.79	medium_impact	0.42	0.8	31.59	21.45	0.37	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11528	11528	A	C	MI.17937	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	769	257	M	L	Ata/Cta	-4.58	0	0	probably_damaging	0.98	neutral	1	neutral	4.75	neutral	1.94	neutral	-1.28	neutral_impact	-0.29	0.65	neutral	0.87	neutral	0.70	8.84	deleterious	0.24	0.45	0.51	disease	0.23	neutral	0.4	neutral	0.34	neutral	3	0.98	deleterious	0.51	deleterious	-2	neutral	0.50	deleterious	-2.31	low_impact	1.88	high_impact	-1.41	low_impact	0.37	0.8	18.3	19.19	0.31	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11528	11528	A	G	MI.17938	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	769	257	M	V	Ata/Gta	-4.58	0	0	probably_damaging	0.99	neutral	0.24	neutral	4.7	neutral	0.88	deleterious	-2.6	low_impact	1	0.7	neutral	0.19	damaging	2.51	19.53	deleterious	0.2	0.45	0.67	disease	0.6	disease	0.54	disease	0.53	disease	1	0.99	deleterious	0.13	neutral	-2	neutral	0.64	deleterious	-2.59	low_impact	-0.08	medium_impact	-0.14	medium_impact	0.40	0.8	18.3	19.19	0.27	N	0.81	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11528	11528	A	T	MI.17939	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	769	257	M	L	Ata/Tta	-4.58	0	0	probably_damaging	0.98	neutral	1	neutral	4.75	neutral	1.94	neutral	-1.28	neutral_impact	-0.29	0.65	neutral	0.87	neutral	0.80	9.47	deleterious	0.24	0.45	0.51	disease	0.23	neutral	0.4	neutral	0.34	neutral	3	0.98	deleterious	0.51	deleterious	-2	neutral	0.50	deleterious	-2.31	low_impact	1.88	high_impact	-1.41	low_impact	0.37	0.8	18.3	19.19	0.34	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8531	8531	A	G	MI.1794	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	166	56	T	A	Acg/Gcg	6.84	1	0	possibly_damaging	0.9	neutral	0.51	neutral	0.9	deleterious	-4.04	deleterious	-4.64	high_impact	3.52	0.99	neutral	0.53	neutral	3.55	23.10	deleterious	0.51274914	0.85	0.38	neutral	0.38	neutral	0.72	disease	0.27	neutral	5	0.89	neutral	0.31	neutral	1	deleterious	0.72	deleterious	-1.66	low_impact	0.3	medium_impact	1.92	medium_impact	0.63	0.85	19.12	8.91	0.67	P	0.79	disease_causing	0.99	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11529	11529	T	A	MI.17940	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	770	257	M	K	aTa/aAa	-0.66	0	0	probably_damaging	1	deleterious	0.01	neutral	4.56	neutral	-1.84	deleterious	-4.62	medium_impact	2.19	0.61	neutral	0.12	damaging	4.03	23.60	deleterious	0.04	0.35	0.78	disease	0.82	disease	0.75	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	1.04	medium_impact	0.19	0.8	18.3	19.19	0.25	N	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11529	11529	T	C	MI.17941	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	770	257	M	T	aTa/aCa	-0.66	0	0	probably_damaging	1	neutral	0.09	neutral	4.6	neutral	-0.17	deleterious	-4.3	low_impact	1.66	0.77	neutral	0.24	damaging	2.99	22.20	deleterious	0.16	0.45	0.52	disease	0.61	disease	0.53	disease	0.56	disease	1	1	deleterious	0.05	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	-0.36	medium_impact	0.52	medium_impact	0.21	0.8	18.3	19.19	0.3	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11530	11530	A	T	MI.17942	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	771	257	M	I	atA/atT	5.78	0.87	0	probably_damaging	0.99	neutral	0.29	neutral	4.74	neutral	0.59	neutral	-2.36	low_impact	1.12	0.74	neutral	0.21	damaging	3.53	23.10	deleterious	0.27	0.45	0.59	disease	0.6	disease	0.51	disease	0.49	neutral	0	0.99	deleterious	0.15	neutral	-2	neutral	0.69	deleterious	-2.59	low_impact	-0.02	medium_impact	-0.02	medium_impact	0.43	0.8	18.3	19.19	0.47	N	0.78	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11530	11530	A	C	MI.17943	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	771	257	M	I	atA/atC	5.78	0.87	0	probably_damaging	0.99	neutral	0.29	neutral	4.74	neutral	0.59	neutral	-2.36	low_impact	1.12	0.74	neutral	0.21	damaging	3.42	23.00	deleterious	0.27	0.45	0.59	disease	0.6	disease	0.51	disease	0.49	neutral	0	0.99	deleterious	0.15	neutral	-2	neutral	0.69	deleterious	-2.59	low_impact	-0.02	medium_impact	-0.02	medium_impact	0.43	0.8	18.3	19.19	0.46	N	0.78	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11531	11531	G	T	MI.17944	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	772	258	A	S	Gcc/Tcc	-1.58	0	0	possibly_damaging	0.62	neutral	0.81	neutral	4.72	neutral	0.94	neutral	-0.89	neutral_impact	0.08	0.68	neutral	0.91	neutral	2.04	16.50	deleterious	0.23	0.45	0.68	disease	0.14	neutral	0.26	neutral	0.34	neutral	3	0.55	neutral	0.6	deleterious	-3	neutral	0.72	deleterious	-0.92	medium_impact	0.56	medium_impact	-1.05	low_impact	0.50	0.8	25.49	20.12	0.34	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11531	11531	G	C	MI.17945	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	772	258	A	P	Gcc/Ccc	-1.58	0	0	benign	0.12	neutral	0.21	neutral	4.57	neutral	-2.14	deleterious	-3.02	medium_impact	1.98	0.72	neutral	0.49	neutral	3.81	23.40	deleterious	0.04	0.35	0.89	disease	0.83	disease	0.6	disease	0.77	disease	5	0.76	neutral	0.55	deleterious	-3	neutral	0.88	deleterious	0.1	medium_impact	-0.12	medium_impact	0.83	medium_impact	0.42	0.8	25.49	20.12	0.3	N	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11531	11531	G	A	MI.17946	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	772	258	A	T	Gcc/Acc	-1.58	0	0	benign	0.18	neutral	0.44	neutral	4.65	neutral	0.14	neutral	-1.74	low_impact	1.27	0.77	neutral	0.61	neutral	3.12	22.60	deleterious	0.17	0.45	0.55	disease	0.41	neutral	0.31	neutral	0.6	disease	2	0.47	neutral	0.63	deleterious	-6	neutral	0.72	deleterious	-0.1	medium_impact	0.14	medium_impact	0.13	medium_impact	0.68	0.85	25.49	20.12	0.34	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11532	11532	C	G	MI.17947	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	773	258	A	G	gCc/gGc	-0.2	0	0	benign	0.08	neutral	0.42	neutral	4.58	neutral	-1.58	neutral	-2.45	neutral_impact	0.78	0.79	neutral	0.68	neutral	2.87	21.70	deleterious	0.23	0.45	0.76	disease	0.45	neutral	0.4	neutral	0.64	disease	3	0.53	neutral	0.67	deleterious	-6	neutral	0.75	deleterious	0.28	medium_impact	0.12	medium_impact	-0.35	medium_impact	0.54	0.8	25.49	20.12	0.31	N	0.65	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11532	11532	C	T	MI.17948	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	773	258	A	V	gCc/gTc	-0.2	0	0	possibly_damaging	0.73	neutral	0.52	neutral	4.61	neutral	-0.62	neutral	-2.07	low_impact	1.4	0.76	neutral	0.58	neutral	3.33	22.90	deleterious	0.13	0.4	0.5	neutral	0.55	disease	0.45	neutral	0.47	neutral	1	0.7	neutral	0.4	neutral	-3	neutral	0.73	deleterious	-1.12	low_impact	0.22	medium_impact	0.26	medium_impact	0.65	0.8	25.49	20.12	0.33	N	0.82	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11532	11532	C	A	MI.17949	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	773	258	A	D	gCc/gAc	-0.2	0	0	possibly_damaging	0.9	neutral	0.2	neutral	4.59	neutral	-1.12	deleterious	-3.36	medium_impact	2.19	0.79	neutral	0.4	neutral	4.66	24.50	deleterious	0.05	0.35	0.93	disease	0.8	disease	0.61	disease	0.8	disease	6	0.94	neutral	0.15	neutral	0	NA	0.85	deleterious	-1.61	low_impact	-0.14	medium_impact	1.04	medium_impact	0.15	0.8	25.49	20.12	0.32	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8531	8531	A	T	MI.1795	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	166	56	T	S	Acg/Tcg	6.84	1	0	possibly_damaging	0.9	neutral	0.4	neutral	0.88	deleterious	-4.36	deleterious	-3.68	high_impact	3.52	0.99	neutral	0.46	neutral	3.71	23.30	deleterious	0.44721401	0.85	0.46	neutral	0.36	neutral	0.71	disease	0.26	neutral	5	0.9	neutral	0.25	neutral	1	deleterious	0.72	deleterious	-1.66	low_impact	0.19	medium_impact	1.92	medium_impact	0.66	0.85	19.12	8.91	0.71	P	0.75	disease_causing	0.98	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11534	11534	T	G	MI.17950	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	775	259	Y	D	Tac/Gac	-9.41	0	0	probably_damaging	1	neutral	0.05	neutral	4.52	neutral	-2.07	deleterious	-9.2	medium_impact	2.9	0.68	neutral	0.11	damaging	4.03	23.60	deleterious	0.06	0.35	0.9	disease	0.88	disease	0.77	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.52	medium_impact	1.74	medium_impact	0.18	0.8	47.71	9.23	0.37	N	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11534	11534	T	A	MI.17951	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	775	259	Y	N	Tac/Aac	-9.41	0	0	probably_damaging	1	neutral	0.12	neutral	4.63	neutral	-0.15	deleterious	-8.3	medium_impact	2.33	0.73	neutral	0.14	damaging	4.06	23.70	deleterious	0.12	0.4	0.83	disease	0.84	disease	0.67	disease	0.68	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.28	medium_impact	1.18	medium_impact	0.16	0.8	47.71	9.23	0.3	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11534	11534	T	C	MI.17952	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	775	259	Y	H	Tac/Cac	-9.41	0	0	probably_damaging	1	neutral	0.11	neutral	4.51	neutral	-2.22	deleterious	-4.62	medium_impact	2.83	0.72	neutral	0.12	damaging	3.61	23.20	deleterious	0.18	0.45	0.85	disease	0.82	disease	0.72	disease	0.74	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.31	medium_impact	1.67	medium_impact	0.24	0.8	47.71	9.23	0.27	N	0.97	polymorphism	1	0.06	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11535	11535	A	G	MI.17953	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	776	259	Y	C	tAc/tGc	4.4	0.99	0	probably_damaging	1	neutral	0.07	neutral	4.48	deleterious	-4.08	deleterious	-8.27	medium_impact	3	0.75	neutral	0.1	damaging	4.11	23.70	deleterious	0.06	0.35	0.73	disease	0.87	disease	0.72	disease	0.73	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.43	medium_impact	1.84	medium_impact	0.09	0.8	47.71	9.23	0.5	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11535	11535	A	T	MI.17954	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	776	259	Y	F	tAc/tTc	4.4	0.99	0	probably_damaging	1	neutral	0.26	neutral	4.5	neutral	-2.88	deleterious	-3.56	low_impact	1.4	0.77	neutral	0.27	damaging	3.94	23.50	deleterious	0.3	0.45	0.64	disease	0.66	disease	0.49	neutral	0.42	neutral	2	1	deleterious	0.13	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	-0.05	medium_impact	0.26	medium_impact	0.32	0.8	47.71	9.23	0.52	N	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11535	11535	A	C	MI.17955	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	776	259	Y	S	tAc/tCc	4.4	0.99	0	probably_damaging	1	neutral	0.18	neutral	4.59	neutral	-0.53	deleterious	-8.27	low_impact	1.7	0.7	neutral	0.15	damaging	4.26	23.90	deleterious	0.09	0.35	0.63	disease	0.8	disease	0.67	disease	0.56	disease	1	1	deleterious	0.09	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	-0.17	medium_impact	0.56	medium_impact	0.18	0.8	47.71	9.23	0.48	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11537	11537	C	A	MI.17956	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	778	260	P	T	Ccc/Acc	-2.5	0	0	probably_damaging	1	neutral	0.39	neutral	4.66	neutral	0.36	deleterious	-7.46	medium_impact	3.03	0.48	damaging	0.08	damaging	3.83	23.40	deleterious	0.13	0.4	0.5	neutral	0.82	disease	0.66	disease	0.67	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.09	medium_impact	1.87	medium_impact	0.59	0.8	47.06	9.39	0.3	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11537	11537	C	G	MI.17957	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	778	260	P	A	Ccc/Gcc	-2.5	0	0	probably_damaging	1	neutral	0.51	neutral	4.67	neutral	0.71	deleterious	-7.46	medium_impact	3.29	0.52	damaging	0.11	damaging	3.08	22.50	deleterious	0.13	0.4	0.47	neutral	0.69	disease	0.67	disease	0.56	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.21	medium_impact	2.13	high_impact	0.64	0.8	47.06	9.39	0.29	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11537	11537	C	T	MI.17958	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	778	260	P	S	Ccc/Tcc	-2.5	0	0	probably_damaging	1	neutral	0.4	neutral	4.64	neutral	-0.01	deleterious	-7.46	medium_impact	2.77	0.52	damaging	0.09	damaging	3.86	23.50	deleterious	0.14	0.4	0.44	neutral	0.8	disease	0.66	disease	0.58	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.1	medium_impact	1.61	medium_impact	0.32	0.8	47.06	9.39	0.23	N	0.71	polymorphism	1	0.07	rs879001835	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11538	11538	C	T	MI.17959	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	779	260	P	L	cCc/cTc	4.4	0.99	0	probably_damaging	1	neutral	0.68	neutral	4.84	neutral	2.5	deleterious	-9.32	medium_impact	2.17	0.47	damaging	0.1	damaging	4.46	24.20	deleterious	0.1	0.4	0.64	disease	0.85	disease	0.51	disease	0.38	neutral	3	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	0.39	medium_impact	1.02	medium_impact	0.55	0.8	47.06	9.39	0.45	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8531	8531	A	C	MI.1796	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	166	56	T	P	Acg/Ccg	6.84	1	0	probably_damaging	0.96	neutral	0.31	neutral	0.83	deleterious	-6.14	deleterious	-5.57	medium_impact	2.98	0.98	neutral	0.56	neutral	3.61	23.20	deleterious	0.20425263	0.85	0.73	disease	0.6	disease	0.69	disease	0.63	disease	3	0.97	neutral	0.18	neutral	1	deleterious	0.82	deleterious	-2.07	low_impact	0.1	medium_impact	1.46	medium_impact	0.53	0.85	19.12	8.91	0.67	P	0.89	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11538	11538	C	A	MI.17960	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	779	260	P	H	cCc/cAc	4.4	0.99	0	probably_damaging	1	neutral	0.53	neutral	4.61	neutral	-1.51	deleterious	-8.39	high_impact	4.18	0.53	damaging	0.05	damaging	4.09	23.70	deleterious	0.06	0.35	0.81	disease	0.87	disease	0.78	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.54	low_impact	0.23	medium_impact	3.01	high_impact	0.44	0.8	47.06	9.39	0.61	P	0.70	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11538	11538	C	G	MI.17961	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	779	260	P	R	cCc/cGc	4.4	0.99	0	probably_damaging	1	neutral	0.34	neutral	4.62	neutral	-0.97	deleterious	-8.39	high_impact	4.18	0.47	damaging	0.05	damaging	3.66	23.20	deleterious	0.05	0.35	0.75	disease	0.91	disease	0.78	disease	0.75	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.04	medium_impact	3.01	high_impact	0.55	0.8	47.06	9.39	0.66	P	0.58	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11540	11540	T	A	MI.17962	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	781	261	F	I	Ttc/Atc	-6.88	0	0	probably_damaging	0.91	neutral	0.42	neutral	4.82	neutral	1.31	deleterious	-5.44	low_impact	1.4	0.78	neutral	0.66	neutral	4.40	24.10	deleterious	0.12	0.4	0.38	neutral	0.82	disease	0.46	neutral	0.36	neutral	3	0.91	neutral	0.26	neutral	-2	neutral	0.73	deleterious	-1.66	low_impact	0.12	medium_impact	0.26	medium_impact	0.55	0.8	47.93	9.59	0.33	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11540	11540	T	C	MI.17963	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	781	261	F	L	Ttc/Ctc	-6.88	0	0	possibly_damaging	0.8	neutral	0.57	neutral	4.93	neutral	1.83	deleterious	-5.47	neutral_impact	0.44	0.74	neutral	0.63	neutral	4.05	23.70	deleterious	0.17	0.45	0.44	neutral	0.76	disease	0.47	neutral	0.37	neutral	3	0.78	neutral	0.39	neutral	-3	neutral	0.73	deleterious	-1.28	low_impact	0.27	medium_impact	-0.69	medium_impact	0.69	0.85	47.93	9.59	0.34	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11540	11540	T	G	MI.17964	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	781	261	F	V	Ttc/Gtc	-6.88	0	0	possibly_damaging	0.88	neutral	0.1	neutral	4.69	neutral	0.5	deleterious	-6.37	medium_impact	1.99	0.73	neutral	0.57	neutral	4.18	23.80	deleterious	0.1	0.4	0.59	disease	0.88	disease	0.5	neutral	0.54	disease	1	0.96	neutral	0.11	neutral	0	NA	0.78	deleterious	-1.53	low_impact	-0.33	medium_impact	0.84	medium_impact	0.40	0.8	47.93	9.59	0.36	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11541	11541	T	G	MI.17965	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	782	261	F	C	tTc/tGc	5.78	1	0	probably_damaging	0.98	deleterious	0	neutral	4.53	deleterious	-3.06	deleterious	-7.35	medium_impact	3.08	0.75	neutral	0.47	neutral	4.14	23.80	deleterious	0.04	0.35	0.67	disease	0.88	disease	0.67	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.31	low_impact	-1.48	low_impact	1.92	medium_impact	0.27	0.8	47.93	9.59	0.57	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11541	11541	T	A	MI.17966	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	782	261	F	Y	tTc/tAc	5.78	1	0	probably_damaging	0.92	deleterious	0.02	neutral	4.54	neutral	-2.25	deleterious	-2.77	medium_impact	2.54	0.73	neutral	0.53	neutral	4.27	24.00	deleterious	0.13	0.4	0.83	disease	0.81	disease	0.66	disease	0.7	disease	4	0.99	deleterious	0.05	neutral	5	deleterious	0.80	deleterious	-1.71	low_impact	-0.75	medium_impact	1.39	medium_impact	0.58	0.8	47.93	9.59	0.61	P	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11541	11541	T	C	MI.17967	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	782	261	F	S	tTc/tCc	5.78	1	0	benign	0.2	deleterious	0	neutral	4.55	neutral	-1.78	deleterious	-7.37	medium_impact	3.34	0.71	neutral	0.54	neutral	4.29	24.00	deleterious	0.04	0.35	0.57	disease	0.85	disease	0.66	disease	0.71	disease	4	1	deleterious	0.4	neutral	1	deleterious	0.79	deleterious	-0.15	medium_impact	-1.48	low_impact	2.18	high_impact	0.35	0.8	47.93	9.59	0.6	P	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11542	11542	C	G	MI.17968	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	783	261	F	L	ttC/ttG	7.4	1	0	possibly_damaging	0.8	neutral	0.57	neutral	4.93	neutral	1.83	deleterious	-5.47	neutral_impact	0.44	0.74	neutral	0.63	neutral	4.36	24.10	deleterious	0.17	0.45	0.44	neutral	0.76	disease	0.47	neutral	0.37	neutral	3	0.78	neutral	0.39	neutral	-3	neutral	0.73	deleterious	-1.28	low_impact	0.27	medium_impact	-0.69	medium_impact	0.69	0.85	47.93	9.59	0.5	P	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11542	11542	C	A	MI.17969	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	783	261	F	L	ttC/ttA	7.4	1	0	possibly_damaging	0.8	neutral	0.57	neutral	4.93	neutral	1.83	deleterious	-5.47	neutral_impact	0.44	0.74	neutral	0.63	neutral	4.69	24.60	deleterious	0.17	0.45	0.44	neutral	0.76	disease	0.47	neutral	0.37	neutral	3	0.78	neutral	0.39	neutral	-3	neutral	0.73	deleterious	-1.28	low_impact	0.27	medium_impact	-0.69	medium_impact	0.69	0.85	47.93	9.59	0.5	P	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8532	8532	C	T	MI.1797	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	167	56	T	M	aCg/aTg	1.75	0.87	0	probably_damaging	0.99	neutral	0.22	neutral	0.81	deleterious	-6.69	deleterious	-5.57	high_impact	3.52	1	neutral	0.42	neutral	4.08	23.70	deleterious	0.38597345	0.85	0.82	disease	0.42	neutral	0.74	disease	0.34	neutral	3	0.99	deleterious	0.12	neutral	2	deleterious	0.82	deleterious	-2.65	low_impact	-0.02	medium_impact	1.92	medium_impact	0.73	0.85	19.12	8.91	0.56	P	0.90	disease_causing	0.5	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11543	11543	C	G	MI.17970	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	784	262	L	V	Ctt/Gtt	-2.96	0	0	benign	0.41	neutral	0.28	neutral	4.55	neutral	-1.17	neutral	-0.21	low_impact	1.01	0.76	neutral	0.89	neutral	1.53	13.50	neutral	0.24	0.45	0.63	disease	0.57	disease	0.37	neutral	0.27	neutral	5	0.67	neutral	0.44	neutral	-6	neutral	0.27	neutral	-0.57	medium_impact	-0.03	medium_impact	-0.13	medium_impact	0.51	0.8	11.76	23.44	0.39	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11543	11543	C	T	MI.17971	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	784	262	L	F	Ctt/Ttt	-2.96	0	0	probably_damaging	0.93	neutral	0.11	neutral	4.44	neutral	-2.98	neutral	-2.35	low_impact	1.51	0.72	neutral	0.7	neutral	3.63	23.20	deleterious	0.18	0.45	0.67	disease	0.66	disease	0.58	disease	0.55	disease	1	0.97	neutral	0.09	neutral	-2	neutral	0.64	deleterious	-1.77	low_impact	-0.31	medium_impact	0.37	medium_impact	0.52	0.8	11.76	23.44	0.32	N	0.26	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11543	11543	C	A	MI.17972	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	784	262	L	I	Ctt/Att	-2.96	0	0	benign	0.2	neutral	1	neutral	4.55	neutral	-0.85	neutral	0.64	neutral_impact	-0.29	0.69	neutral	0.99	neutral	-0.50	0.22	neutral	0.3	0.45	0.55	disease	0.1	neutral	0.24	neutral	0.31	neutral	4	0.2	neutral	0.9	deleterious	-6	neutral	0.15	neutral	-0.15	medium_impact	1.88	high_impact	-1.41	low_impact	0.38	0.8	11.76	23.44	0.32	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11544	11544	T	C	MI.17973	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	785	262	L	P	cTt/cCt	-0.2	0	0	probably_damaging	0.99	deleterious	0	neutral	4.37	deleterious	-4.96	deleterious	-5.07	medium_impact	3.31	0.6	neutral	0.39	neutral	3.86	23.50	deleterious	0.02	0.35	0.91	disease	0.91	disease	0.72	disease	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.87	deleterious	-2.59	low_impact	-1.48	low_impact	2.15	high_impact	0.31	0.8	11.76	23.44	0.29	N	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11544	11544	T	G	MI.17974	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	785	262	L	R	cTt/cGt	-0.2	0	0	probably_damaging	0.98	deleterious	0	neutral	4.37	deleterious	-4.6	deleterious	-4.74	medium_impact	3.31	0.67	neutral	0.45	neutral	4.11	23.70	deleterious	0.02	0.35	0.88	disease	0.93	disease	0.71	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.86	deleterious	-2.31	low_impact	-1.48	low_impact	2.15	high_impact	0.24	0.8	11.76	23.44	0.32	N	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11544	11544	T	A	MI.17975	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	785	262	L	H	cTt/cAt	-0.2	0	0	probably_damaging	0.99	deleterious	0	neutral	4.37	deleterious	-5.18	deleterious	-5.07	medium_impact	3.31	0.73	neutral	0.51	neutral	4.03	23.70	deleterious	0.04	0.35	0.91	disease	0.77	disease	0.67	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-2.59	low_impact	-1.48	low_impact	2.15	high_impact	0.20	0.8	11.76	23.44	0.31	N	0.77	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11546	11546	G	T	MI.17976	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	787	263	V	L	Gta/Tta	-5.73	0	0	benign	0.01	neutral	0.39	neutral	4.69	neutral	-1	neutral	-0.04	neutral_impact	-0.26	0.77	neutral	0.92	neutral	0.41	6.68	deleterious	0.13	0.4	0.43	neutral	0.6	disease	0.32	neutral	0.25	neutral	5	0.6	neutral	0.69	deleterious	-6	neutral	0.17	neutral	1.16	medium_impact	0.09	medium_impact	-1.38	low_impact	0.42	0.8	24.4	18.58	0.32	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11546	11546	G	C	MI.17977	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	787	263	V	L	Gta/Cta	-5.73	0	0	benign	0.01	neutral	0.39	neutral	4.69	neutral	-1	neutral	-0.04	neutral_impact	-0.26	0.77	neutral	0.92	neutral	0.25	5.17	deleterious	0.13	0.4	0.43	neutral	0.6	disease	0.32	neutral	0.25	neutral	5	0.6	neutral	0.69	deleterious	-6	neutral	0.17	neutral	1.16	medium_impact	0.09	medium_impact	-1.38	low_impact	0.42	0.8	24.4	18.58	0.31	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11546	11546	G	A	MI.17978	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	787	263	V	M	Gta/Ata	-5.73	0	0	benign	0	neutral	0.26	neutral	4.55	deleterious	-3.11	neutral	0.06	neutral_impact	-0.34	0.73	neutral	0.97	neutral	0.08	3.36	deleterious	0.16	0.45	0.61	disease	0.39	neutral	0.33	neutral	0.61	disease	2	0.74	neutral	0.63	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	-0.05	medium_impact	-1.46	low_impact	0.58	0.8	24.4	18.58	0.41	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11547	11547	T	A	MI.17979	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	788	263	V	E	gTa/gAa	-0.2	0	0	benign	0.1	neutral	0.07	neutral	4.48	deleterious	-4.9	deleterious	-4.35	medium_impact	2.26	0.73	neutral	0.5	neutral	2.65	20.50	deleterious	0.02	0.35	0.87	disease	0.86	disease	0.67	disease	0.74	disease	5	0.92	neutral	0.49	deleterious	-3	neutral	0.33	neutral	0.18	medium_impact	-0.43	medium_impact	1.11	medium_impact	0.20	0.8	24.4	18.58	0.31	N	0.33	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8532	8532	C	A	MI.1798	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	167	56	T	K	aCg/aAg	1.75	0.87	0	probably_damaging	0.96	neutral	0.38	neutral	0.84	deleterious	-5.43	deleterious	-5.3	high_impact	3.52	0.99	neutral	0.36	neutral	4.56	24.40	deleterious	0.22335685	0.85	0.69	disease	0.56	disease	0.7	disease	0.65	disease	3	0.96	neutral	0.21	neutral	2	deleterious	0.82	deleterious	-2.07	low_impact	0.17	medium_impact	1.92	medium_impact	0.62	0.85	19.12	8.91	0.53	N	0.91	disease_causing	0.65	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11547	11547	T	G	MI.17980	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	788	263	V	G	gTa/gGa	-0.2	0	0	benign	0.06	neutral	0.17	neutral	4.51	neutral	-2.84	deleterious	-5.25	neutral_impact	0.72	0.73	neutral	0.55	neutral	1.80	15.00	deleterious	0.04	0.35	0.79	disease	0.66	disease	0.54	disease	0.39	neutral	2	0.82	neutral	0.56	deleterious	-6	neutral	0.24	neutral	0.41	medium_impact	-0.18	medium_impact	-0.41	medium_impact	0.31	0.8	24.4	18.58	0.26	N	0.36	polymorphism	1	0.08	rs28588421	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11547	11547	T	C	MI.17981	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	788	263	V	A	gTa/gCa	-0.2	0	0	benign	0	neutral	0.34	neutral	4.58	neutral	-1.12	deleterious	-2.71	neutral_impact	-0.4	0.74	neutral	0.92	neutral	0.44	6.97	deleterious	0.1	0.4	0.38	neutral	0.44	neutral	0.36	neutral	0.44	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.04	medium_impact	-1.52	low_impact	0.16	0.8	24.4	18.58	0.4	N	0.04	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11549	11549	C	A	MI.17982	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	790	264	L	M	Cta/Ata	-3.89	0	0	probably_damaging	1	deleterious	0.03	neutral	4.35	deleterious	-3.07	neutral	-1.73	medium_impact	2.58	0.74	neutral	0.28	neutral	3.67	23.30	deleterious	0.2	0.45	0.54	disease	0.55	disease	0.44	neutral	0.21	neutral	6	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-3.54	low_impact	-0.64	medium_impact	1.43	medium_impact	0.45	0.8	46.19	9.24	0.34	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11549	11549	C	G	MI.17983	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	790	264	L	V	Cta/Gta	-3.89	0	0	probably_damaging	1	neutral	0.2	neutral	4.51	neutral	-1.51	deleterious	-2.72	medium_impact	2.18	0.73	neutral	0.25	damaging	3.42	23.00	deleterious	0.19	0.45	0.68	disease	0.66	disease	0.64	disease	0.49	neutral	0	1	deleterious	0.1	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.14	medium_impact	1.03	medium_impact	0.51	0.8	46.19	9.24	0.28	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11550	11550	T	G	MI.17984	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	791	264	L	R	cTa/cGa	-2.73	0	0	probably_damaging	1	deleterious	0	neutral	4.31	deleterious	-5.49	deleterious	-5.51	high_impact	4.25	0.61	neutral	0.13	damaging	4.17	23.80	deleterious	0.03	0.35	0.94	disease	0.92	disease	0.76	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.19	0.8	46.19	9.24	0.37	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11550	11550	T	A	MI.17985	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	791	264	L	Q	cTa/cAa	-2.73	0	0	probably_damaging	1	deleterious	0	neutral	4.31	deleterious	-5.56	deleterious	-5.48	high_impact	4.25	0.69	neutral	0.16	damaging	4.27	24.00	deleterious	0.03	0.35	0.94	disease	0.82	disease	0.65	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.31	0.8	46.19	9.24	0.33	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11550	11550	T	C	MI.17986	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	791	264	L	P	cTa/cCa	-2.73	0	0	probably_damaging	1	deleterious	0	neutral	4.3	deleterious	-5.67	deleterious	-6.43	high_impact	3.9	0.59	damaging	0.14	damaging	4.01	23.60	deleterious	0.03	0.35	0.95	disease	0.86	disease	0.76	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	2.73	high_impact	0.38	0.8	46.19	9.24	0.33	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11552	11552	T	C	MI.17987	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	793	265	S	P	Tcc/Ccc	-5.96	0	0	probably_damaging	0.97	deleterious	0.03	neutral	4.44	deleterious	-3.36	deleterious	-3.71	high_impact	3.99	0.64	neutral	0.11	damaging	3.94	23.50	deleterious	0.03	0.35	0.84	disease	0.92	disease	0.76	disease	0.73	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.89	deleterious	-2.14	low_impact	-0.64	medium_impact	2.82	high_impact	0.31	0.8	40.31	8.51	0.37	N	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11552	11552	T	A	MI.17988	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	793	265	S	T	Tcc/Acc	-5.96	0	0	possibly_damaging	0.74	neutral	0.09	neutral	4.48	neutral	-0.83	neutral	-2.14	medium_impact	2.54	0.67	neutral	0.14	damaging	3.78	23.40	deleterious	0.11	0.4	0.54	disease	0.68	disease	0.63	disease	0.69	disease	4	0.93	neutral	0.18	neutral	0	NA	0.75	deleterious	-1.14	low_impact	-0.36	medium_impact	1.39	medium_impact	0.51	0.8	40.31	8.51	0.32	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11552	11552	T	G	MI.17989	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	793	265	S	A	Tcc/Gcc	-5.96	0	0	benign	0.08	neutral	0.85	neutral	4.65	neutral	1.46	neutral	-0.89	neutral_impact	0.42	0.62	neutral	0.47	neutral	0.94	10.29	neutral	0.12	0.4	0.4	neutral	0.14	neutral	0.32	neutral	0.23	neutral	5	0.06	neutral	0.89	deleterious	-6	neutral	0.66	deleterious	0.28	medium_impact	0.62	medium_impact	-0.71	medium_impact	0.33	0.8	40.31	8.51	0.34	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8534	8534	A	C	MI.1799	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	169	57	K	Q	Aaa/Caa	-0.1	0.06	0	probably_damaging	0.96	neutral	0.45	neutral	0.7	deleterious	-5.01	deleterious	-3.72	high_impact	3.52	0.8	neutral	0.09	damaging	3.42	23.00	deleterious	0.42430023	0.85	0.66	disease	0.54	disease	0.75	disease	0.66	disease	3	0.96	neutral	0.25	neutral	2	deleterious	0.79	deleterious	-2.07	low_impact	0.24	medium_impact	1.92	medium_impact	0.74	0.85	20.59	8.73	0.3	N	0.80	polymorphism	0.99	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11553	11553	C	T	MI.17990	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	794	265	S	F	tCc/tTc	2.79	0.99	0	probably_damaging	0.97	neutral	0.06	neutral	4.46	neutral	-2.33	deleterious	-4.61	medium_impact	3.02	0.6	damaging	0.11	damaging	4.22	23.90	deleterious	0.03	0.35	0.44	neutral	0.9	disease	0.66	disease	0.76	disease	5	0.99	deleterious	0.05	neutral	1	deleterious	0.79	deleterious	-2.14	low_impact	-0.47	medium_impact	1.86	medium_impact	0.09	0.8	40.31	8.51	0.46	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11553	11553	C	A	MI.17991	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	794	265	S	Y	tCc/tAc	2.79	0.99	0	probably_damaging	0.98	neutral	0.05	neutral	4.45	neutral	-2.88	deleterious	-4.61	high_impact	3.64	0.66	neutral	0.1	damaging	4.19	23.90	deleterious	0.03	0.35	0.69	disease	0.88	disease	0.66	disease	0.76	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.83	deleterious	-2.31	low_impact	-0.52	medium_impact	2.48	high_impact	0.22	0.8	40.31	8.51	0.52	P	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11553	11553	C	G	MI.17992	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	794	265	S	C	tCc/tGc	2.79	0.99	0	probably_damaging	0.98	neutral	0.21	neutral	4.45	neutral	-2.9	deleterious	-3.21	medium_impact	2.19	0.62	neutral	0.26	damaging	2.48	19.34	deleterious	0.03	0.35	0.76	disease	0.82	disease	0.44	neutral	0.28	neutral	4	0.98	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-2.31	low_impact	-0.12	medium_impact	1.04	medium_impact	0.26	0.8	40.31	8.51	0.45	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11555	11555	C	G	MI.17993	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	796	266	L	V	Cta/Gta	-8.26	0	0	probably_damaging	1	neutral	0.11	neutral	4.66	neutral	-0.18	neutral	-2.36	medium_impact	2.25	0.68	neutral	0.18	damaging	3.45	23.00	deleterious	0.34	0.5	0.67	disease	0.67	disease	0.61	disease	0.63	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.31	medium_impact	1.1	medium_impact	0.38	0.8	18.74	11.36	0.28	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11555	11555	C	A	MI.17994	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	796	266	L	M	Cta/Ata	-8.26	0	0	probably_damaging	1	neutral	0.08	neutral	4.49	neutral	-2.89	neutral	-1.42	medium_impact	2.46	0.78	neutral	0.82	neutral	2.68	20.70	deleterious	0.26	0.45	0.77	disease	0.48	neutral	0.41	neutral	0.47	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.39	medium_impact	1.31	medium_impact	0.48	0.8	18.74	11.36	0.4	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11556	11556	T	C	MI.17995	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	797	266	L	P	cTa/cCa	-1.81	0	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-5.01	deleterious	-6.03	high_impact	4.42	0.57	damaging	0.1	damaging	3.93	23.50	deleterious	0.03	0.35	0.97	disease	0.82	disease	0.74	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.28	0.8	18.74	11.36	0.39	N	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11556	11556	T	G	MI.17996	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	797	266	L	R	cTa/cGa	-1.81	0	0	probably_damaging	1	deleterious	0.02	neutral	4.47	deleterious	-4.62	deleterious	-5.17	high_impact	4.42	0.61	neutral	0.1	damaging	4.22	23.90	deleterious	0.03	0.35	0.95	disease	0.9	disease	0.73	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-0.75	medium_impact	3.25	high_impact	0.12	0.8	18.74	11.36	0.42	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11556	11556	T	A	MI.17997	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	797	266	L	Q	cTa/cAa	-1.81	0	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-4.8	deleterious	-5.11	high_impact	4.42	0.6	damaging	0.11	damaging	4.09	23.70	deleterious	0.05	0.35	0.96	disease	0.78	disease	0.62	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.25	high_impact	0.20	0.8	18.74	11.36	0.36	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11558	11558	T	C	MI.17998	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	799	267	W	R	Tga/Cga	0.03	0.97	0	probably_damaging	1	deleterious	0.02	neutral	4.61	neutral	-1.71	deleterious	-13.07	high_impact	3.83	0.45	damaging	0.05	damaging	3.59	23.20	deleterious	0.06	0.35	0.79	disease	0.92	disease	0.81	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-0.75	medium_impact	2.66	high_impact	0.11	0.8	46.19	9.33	0.56	P	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11558	11558	T	G	MI.17999	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	799	267	W	G	Tga/Gga	0.03	0.97	0	probably_damaging	1	deleterious	0.02	neutral	4.61	neutral	0.06	deleterious	-12.13	medium_impact	3.08	0.48	damaging	0.08	damaging	3.91	23.50	deleterious	0.08	0.35	0.42	neutral	0.87	disease	0.77	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.54	low_impact	-0.75	medium_impact	1.92	medium_impact	0.09	0.8	46.19	9.33	0.49	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8534	8534	A	G	MI.18	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	8	3	E	G	gAa/gGa	-0.1	0.06	0	probably_damaging	0.97	neutral	0.37	neutral	4.62	neutral	-1.22	deleterious	-3.74	low_impact	1.61	0.83	neutral	0.59	neutral	4.02	23.60	deleterious	0.68	0.75	0.26	neutral	0.14	neutral	0.3	neutral	0.35	neutral	3	0.97	neutral	0.2	neutral	-2	neutral	0.61	deleterious	-2.19	low_impact	0.16	medium_impact	0.28	medium_impact	0.64	0.9	15.93	14.48	0.38	N	0.64	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8609	8609	C	T	MI.180	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	83	28	P	L	cCt/cTt	-0.57	0	0	possibly_damaging	0.52	neutral	1	neutral	4.61	neutral	3.81	neutral	-0.12	neutral_impact	-0.76	0.9	neutral	0.77	neutral	0.72	8.94	deleterious	0.45	0.65	0.29	neutral	0.26	neutral	0.11	neutral	0.43	neutral	1	0.52	neutral	0.74	deleterious	-3	neutral	0.39	neutral	-0.79	medium_impact	1.98	high_impact	-1.75	low_impact	0.78	0.9	31.86	20.94	0.35	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8534	8534	A	G	MI.1800	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	169	57	K	E	Aaa/Gaa	-0.1	0.06	0	possibly_damaging	0.9	neutral	0.82	neutral	0.71	deleterious	-4.91	deleterious	-3.72	high_impact	3.52	0.56	damaging	0.09	damaging	4.02	23.60	deleterious	0.44721401	0.85	0.66	disease	0.51	disease	0.75	disease	0.67	disease	3	0.88	neutral	0.46	neutral	1	deleterious	0.79	deleterious	-1.66	low_impact	0.66	medium_impact	1.92	medium_impact	0.63	0.85	20.59	8.73	0.32	N	0.86	polymorphism	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11559	11559	G	T	MI.18000	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	800	267	W	L	tGa/tTa	7.4	1	0	probably_damaging	1	neutral	0.32	neutral	4.93	neutral	2.46	deleterious	-12.13	medium_impact	2.02	0.46	damaging	0.07	damaging	4.26	23.90	deleterious	0.11	0.4	0.43	neutral	0.85	disease	0.72	disease	0.43	neutral	1	1	deleterious	0.16	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.02	medium_impact	0.87	medium_impact	0.08	0.8	46.19	9.33	0.52	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11559	11559	G	C	MI.18001	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	800	267	W	S	tGa/tCa	7.4	1	0	probably_damaging	1	deleterious	0.04	neutral	4.63	neutral	-0.37	deleterious	-13.06	high_impact	3.83	0.44	damaging	0.08	damaging	4.05	23.70	deleterious	0.09	0.35	0.54	disease	0.91	disease	0.75	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-0.57	medium_impact	2.66	high_impact	0.07	0.8	46.19	9.33	0.62	P	0.93	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11560	11560	A	T	MI.18002	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	801	267	W	C	tgA/tgT	7.4	1	0.01	probably_damaging	1	deleterious	0.02	neutral	4.61	neutral	-1.38	deleterious	-12.14	medium_impact	3.28	0.46	damaging	0.04	damaging	4.12	23.80	deleterious	0.09	0.35	0.52	disease	0.91	disease	0.77	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.75	medium_impact	2.12	high_impact	0.10	0.8	46.19	9.33	0.61	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11560	11560	A	C	MI.18003	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	801	267	W	C	tgA/tgC	7.4	1	0.01	probably_damaging	1	deleterious	0.02	neutral	4.61	neutral	-1.38	deleterious	-12.14	medium_impact	3.28	0.46	damaging	0.04	damaging	4.04	23.70	deleterious	0.09	0.35	0.52	disease	0.91	disease	0.77	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.75	medium_impact	2.12	high_impact	0.10	0.8	46.19	9.33	0.61	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11561	11561	G	A	MI.18004	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	802	268	G	S	Ggc/Agc	0.95	1	0	possibly_damaging	0.7	deleterious	0.04	neutral	4.87	neutral	0.03	deleterious	-5.63	medium_impact	2.64	0.49	damaging	0.32	neutral	4.18	23.80	deleterious	0.13	0.4	0.39	neutral	0.8	disease	0.61	disease	0.66	disease	3	0.97	neutral	0.17	neutral	4	deleterious	0.77	deleterious	-1.06	low_impact	-0.57	medium_impact	1.49	medium_impact	0.58	0.8	46.41	9.38	0.48	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11561	11561	G	T	MI.18005	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	802	268	G	C	Ggc/Tgc	0.95	1	0	probably_damaging	1	deleterious	0	neutral	4.5	deleterious	-4.78	deleterious	-8.45	high_impact	4.01	0.52	damaging	0.19	damaging	4.23	23.90	deleterious	0.05	0.35	0.68	disease	0.88	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.84	high_impact	0.09	0.8	46.41	9.38	0.5	P	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11561	11561	G	C	MI.18006	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	802	268	G	R	Ggc/Cgc	0.95	1	0	probably_damaging	0.99	deleterious	0	neutral	4.54	neutral	-2.98	deleterious	-7.51	high_impact	4.56	0.53	damaging	0.2	damaging	4.00	23.60	deleterious	0.04	0.35	0.82	disease	0.89	disease	0.78	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.59	low_impact	-1.48	low_impact	3.39	high_impact	0.28	0.8	46.41	9.38	0.59	P	1.00	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11562	11562	G	C	MI.18007	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	803	268	G	A	gGc/gCc	6.01	1	0	probably_damaging	0.92	neutral	0.07	neutral	4.59	neutral	-0.91	deleterious	-5.63	medium_impact	2.78	0.56	damaging	0.36	neutral	3.15	22.60	deleterious	0.13	0.4	0.39	neutral	0.7	disease	0.65	disease	0.66	disease	3	0.98	deleterious	0.08	neutral	1	deleterious	0.76	deleterious	-1.71	low_impact	-0.43	medium_impact	1.62	medium_impact	0.30	0.8	46.41	9.38	0.61	P	0.76	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11562	11562	G	A	MI.18008	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	803	268	G	D	gGc/gAc	6.01	1	0	probably_damaging	0.98	deleterious	0	neutral	4.54	deleterious	-3.18	deleterious	-6.57	high_impact	4.56	0.57	damaging	0.24	damaging	3.87	23.50	deleterious	0.04	0.35	0.9	disease	0.87	disease	0.77	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.31	low_impact	-1.48	low_impact	3.39	high_impact	0.09	0.8	46.41	9.38	0.69	P	0.99	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11562	11562	G	T	MI.18009	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	803	268	G	V	gGc/gTc	6.01	1	0	probably_damaging	0.98	deleterious	0	neutral	4.53	neutral	-2.74	deleterious	-8.45	high_impact	4.01	0.49	damaging	0.26	damaging	3.80	23.40	deleterious	0.04	0.35	0.39	neutral	0.88	disease	0.68	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.31	low_impact	-1.48	low_impact	2.84	high_impact	0.08	0.8	46.41	9.38	0.61	P	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8535	8535	A	C	MI.1801	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	170	57	K	T	aAa/aCa	4.06	1	0	probably_damaging	0.94	neutral	0.44	neutral	0.68	deleterious	-5.6	deleterious	-5.58	high_impact	3.52	0.78	neutral	0.09	damaging	3.66	23.20	deleterious	0.30143898	0.85	0.75	disease	0.54	disease	0.75	disease	0.66	disease	3	0.93	neutral	0.25	neutral	2	deleterious	0.83	deleterious	-1.89	low_impact	0.23	medium_impact	1.92	medium_impact	0.54	0.85	20.59	8.73	0.53	N	0.81	disease_causing	0.62	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11564	11564	A	T	MI.18010	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	805	269	M	L	Ata/Tta	-20	0	0	probably_damaging	0.98	neutral	0.53	neutral	4.67	neutral	0.14	neutral	-1.65	low_impact	1.84	0.54	damaging	0.14	damaging	3.31	22.90	deleterious	0.18	0.45	0.56	disease	0.6	disease	0.41	neutral	0.27	neutral	5	0.98	deleterious	0.28	neutral	-2	neutral	0.56	deleterious	-2.31	low_impact	0.23	medium_impact	0.69	medium_impact	0.12	0.8	46.84	9.04	0.28	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11564	11564	A	C	MI.18011	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	805	269	M	L	Ata/Cta	-20	0	0	probably_damaging	0.98	neutral	0.53	neutral	4.67	neutral	0.14	neutral	-1.65	low_impact	1.84	0.54	damaging	0.14	damaging	3.20	22.70	deleterious	0.18	0.45	0.56	disease	0.6	disease	0.41	neutral	0.27	neutral	5	0.98	deleterious	0.28	neutral	-2	neutral	0.56	deleterious	-2.31	low_impact	0.23	medium_impact	0.69	medium_impact	0.12	0.8	46.84	9.04	0.27	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11564	11564	A	G	MI.18012	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	805	269	M	V	Ata/Gta	-20	0	0	probably_damaging	0.99	neutral	0.97	neutral	4.64	neutral	-0.53	neutral	-1.77	low_impact	1.22	0.65	neutral	0.3	neutral	0.92	10.21	neutral	0.21	0.45	0.4	neutral	0.31	neutral	0.36	neutral	0.45	neutral	1	0.99	deleterious	0.49	deleterious	-2	neutral	0.56	deleterious	-2.59	low_impact	1.05	medium_impact	0.08	medium_impact	0.12	0.8	46.84	9.04	0.23	N	0.96	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11565	11565	T	C	MI.18013	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	806	269	M	T	aTa/aCa	3.25	0.98	0	probably_damaging	1	neutral	0.15	neutral	4.52	neutral	-1.73	deleterious	-4.27	medium_impact	2.01	0.45	damaging	0.17	damaging	2.96	22.10	deleterious	0.09	0.35	0.37	neutral	0.55	disease	0.53	disease	0.45	neutral	1	1	deleterious	0.08	neutral	1	deleterious	0.67	deleterious	-3.54	low_impact	-0.22	medium_impact	0.86	medium_impact	0.04	0.8	46.84	9.04	0.59	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11565	11565	T	A	MI.18014	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	806	269	M	K	aTa/aAa	3.25	0.98	0	probably_damaging	1	neutral	0.09	neutral	4.46	deleterious	-3.93	deleterious	-4.9	medium_impact	3.33	0.45	damaging	0.06	damaging	3.98	23.60	deleterious	0.04	0.35	0.78	disease	0.8	disease	0.68	disease	0.72	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.36	medium_impact	2.17	high_impact	0.10	0.8	46.84	9.04	0.56	P	1.00	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11566	11566	A	T	MI.18015	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	807	269	M	I	atA/atT	2.79	0.98	0	probably_damaging	0.99	neutral	1	neutral	4.68	neutral	0.64	neutral	-1.65	neutral_impact	0.34	0.64	neutral	0.34	neutral	1.36	12.56	neutral	0.2	0.45	0.58	disease	0.32	neutral	0.32	neutral	0.6	disease	2	0.99	deleterious	0.51	deleterious	-2	neutral	0.64	deleterious	-2.59	low_impact	1.88	high_impact	-0.79	medium_impact	0.17	0.8	46.84	9.04	0.42	N	0.95	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11566	11566	A	C	MI.18016	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	807	269	M	I	atA/atC	2.79	0.98	0	probably_damaging	0.99	neutral	1	neutral	4.68	neutral	0.64	neutral	-1.65	neutral_impact	0.34	0.64	neutral	0.34	neutral	1.30	12.27	neutral	0.2	0.45	0.58	disease	0.32	neutral	0.32	neutral	0.6	disease	2	0.99	deleterious	0.51	deleterious	-2	neutral	0.64	deleterious	-2.59	low_impact	1.88	high_impact	-0.79	medium_impact	0.17	0.8	46.84	9.04	0.4	N	0.95	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11567	11567	A	G	MI.18017	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	808	270	I	V	Att/Gtt	-1.81	0	0	benign	0.08	neutral	0.85	neutral	4.37	neutral	-1.65	neutral	-0.42	neutral_impact	0.62	0.78	neutral	0.94	neutral	-0.23	0.95	neutral	0.37	0.5	0.61	disease	0.12	neutral	0.33	neutral	0.31	neutral	4	0.06	neutral	0.89	deleterious	-6	neutral	0.12	neutral	0.28	medium_impact	0.62	medium_impact	-0.51	medium_impact	0.39	0.8	15.69	12.56	0.27	N	0.75	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11567	11567	A	T	MI.18018	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	808	270	I	F	Att/Ttt	-1.81	0	0	probably_damaging	0.96	neutral	0.25	neutral	4.41	neutral	-1.22	deleterious	-3.53	low_impact	1.84	0.69	neutral	0.47	neutral	3.51	23.10	deleterious	0.12	0.4	0.76	disease	0.61	disease	0.53	disease	0.3	neutral	4	0.97	neutral	0.15	neutral	-2	neutral	0.62	deleterious	-2.01	low_impact	-0.07	medium_impact	0.69	medium_impact	0.34	0.8	15.69	12.56	0.32	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11567	11567	A	C	MI.18019	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	808	270	I	L	Att/Ctt	-1.81	0	0	possibly_damaging	0.52	neutral	0.63	neutral	4.89	neutral	0.79	neutral	-1.5	low_impact	0.86	0.73	neutral	0.81	neutral	1.89	15.51	deleterious	0.22	0.45	0.51	disease	0.31	neutral	0.33	neutral	0.34	neutral	3	0.44	neutral	0.56	deleterious	-3	neutral	0.17	neutral	-0.75	medium_impact	0.33	medium_impact	-0.28	medium_impact	0.30	0.8	15.69	12.56	0.32	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8535	8535	A	T	MI.1802	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	170	57	K	M	aAa/aTa	4.06	1	0	probably_damaging	0.99	neutral	0.08	neutral	0.66	deleterious	-7.2	deleterious	-5.58	high_impact	3.52	0.8	neutral	0.09	damaging	4.02	23.60	deleterious	0.24042424	0.85	0.89	disease	0.39	neutral	0.76	disease	0.36	neutral	3	1	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-2.65	low_impact	-0.31	medium_impact	1.92	medium_impact	0.59	0.85	20.59	8.73	0.55	P	0.69	disease_causing	0.79	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11568	11568	T	A	MI.18020	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	809	270	I	N	aTt/aAt	0.26	0.01	0	probably_damaging	0.98	deleterious	0	neutral	4.22	deleterious	-6.55	deleterious	-6.03	high_impact	3.55	0.68	neutral	0.45	neutral	4.44	24.20	deleterious	0.07	0.35	0.59	disease	0.75	disease	0.62	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.67	deleterious	-2.31	low_impact	-1.48	low_impact	2.39	high_impact	0.28	0.8	15.69	12.56	0.34	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11568	11568	T	G	MI.18021	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	809	270	I	S	aTt/aGt	0.26	0.01	0	probably_damaging	0.94	deleterious	0	neutral	4.23	deleterious	-5.38	deleterious	-5.08	medium_impact	2.54	0.71	neutral	0.46	neutral	3.93	23.50	deleterious	0.04	0.35	0.36	neutral	0.76	disease	0.61	disease	0.67	disease	3	1	deleterious	0.03	neutral	5	deleterious	0.49	deleterious	-1.84	low_impact	-1.48	low_impact	1.39	medium_impact	0.17	0.8	15.69	12.56	0.36	N	0.95	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11568	11568	T	C	MI.18022	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	809	270	I	T	aTt/aCt	0.26	0.01	0	possibly_damaging	0.83	deleterious	0.03	neutral	4.23	deleterious	-4.63	deleterious	-3.9	medium_impact	2.52	0.79	neutral	0.61	neutral	1.75	14.72	neutral	0.08	0.35	0.45	neutral	0.54	disease	0.59	disease	0.58	disease	2	0.98	deleterious	0.1	neutral	4	deleterious	0.42	neutral	-1.37	low_impact	-0.64	medium_impact	1.37	medium_impact	0.20	0.8	15.69	12.56	0.4	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11569	11569	T	G	MI.18023	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	810	270	I	M	atT/atG	7.4	0.96	0	probably_damaging	0.96	deleterious	0.04	neutral	4.29	neutral	-2.79	neutral	-2.23	medium_impact	2.52	0.74	neutral	0.53	neutral	3.24	22.80	deleterious	0.21	0.45	0.8	disease	0.48	neutral	0.51	disease	0.6	disease	2	0.99	deleterious	0.04	neutral	5	deleterious	0.61	deleterious	-2.01	low_impact	-0.57	medium_impact	1.37	medium_impact	0.30	0.8	15.69	12.56	0.59	P	0.76	polymorphism	1	0.03	rs386829133	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11569	11569	T	A	MI.18024	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	810	270	I	M	atT/atA	7.4	0.96	0	probably_damaging	0.96	deleterious	0.04	neutral	4.29	neutral	-2.79	neutral	-2.23	medium_impact	2.52	0.74	neutral	0.53	neutral	3.57	23.10	deleterious	0.21	0.45	0.8	disease	0.48	neutral	0.51	disease	0.6	disease	2	0.99	deleterious	0.04	neutral	5	deleterious	0.61	deleterious	-2.01	low_impact	-0.57	medium_impact	1.37	medium_impact	0.30	0.8	15.69	12.56	0.6	P	0.76	polymorphism	1	0.03	rs386829133	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11570	11570	A	T	MI.18025	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	811	271	M	L	Ata/Tta	-2.96	0	0	benign	0.16	neutral	0.61	neutral	4.86	neutral	1.31	deleterious	-2.82	low_impact	1.53	0.7	neutral	0.56	neutral	3.32	22.90	deleterious	0.2	0.45	0.62	disease	0.65	disease	0.51	disease	0.24	neutral	5	0.28	neutral	0.73	deleterious	-6	neutral	0.60	deleterious	-0.04	medium_impact	0.31	medium_impact	0.39	medium_impact	0.17	0.8	47.71	9.47	0.26	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11570	11570	A	C	MI.18026	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	811	271	M	L	Ata/Cta	-2.96	0	0	benign	0.16	neutral	0.61	neutral	4.86	neutral	1.31	deleterious	-2.82	low_impact	1.53	0.7	neutral	0.56	neutral	3.25	22.80	deleterious	0.2	0.45	0.62	disease	0.65	disease	0.51	disease	0.24	neutral	5	0.28	neutral	0.73	deleterious	-6	neutral	0.60	deleterious	-0.04	medium_impact	0.31	medium_impact	0.39	medium_impact	0.17	0.8	47.71	9.47	0.27	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11570	11570	A	G	MI.18027	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	811	271	M	V	Ata/Gta	-2.96	0	0	benign	0.22	neutral	0.14	neutral	4.76	neutral	1.18	deleterious	-3.75	medium_impact	2.25	0.77	neutral	0.55	neutral	2.73	21.00	deleterious	0.19	0.45	0.68	disease	0.72	disease	0.53	disease	0.29	neutral	4	0.84	neutral	0.46	neutral	-3	neutral	0.66	deleterious	-0.2	medium_impact	-0.24	medium_impact	1.1	medium_impact	0.12	0.8	47.71	9.47	0.28	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11571	11571	T	A	MI.18028	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	812	271	M	K	aTa/aAa	6.93	1	0	possibly_damaging	0.86	deleterious	0.01	neutral	4.58	neutral	-2.55	deleterious	-5.63	high_impact	4.01	0.68	neutral	0.39	neutral	3.86	23.50	deleterious	0.04	0.35	0.52	disease	0.87	disease	0.74	disease	0.74	disease	5	0.99	deleterious	0.08	neutral	5	deleterious	0.79	deleterious	-1.46	low_impact	-0.92	medium_impact	2.84	high_impact	0.16	0.8	47.71	9.47	0.63	P	1.00	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11571	11571	T	C	MI.18029	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	812	271	M	T	aTa/aCa	6.93	1	0	possibly_damaging	0.71	deleterious	0.01	neutral	4.61	neutral	-0.8	deleterious	-5.63	medium_impact	3.46	0.68	neutral	0.46	neutral	2.91	21.90	deleterious	0.08	0.35	0.53	disease	0.78	disease	0.67	disease	0.67	disease	3	0.99	deleterious	0.15	neutral	4	deleterious	0.76	deleterious	-1.08	low_impact	-0.92	medium_impact	2.3	high_impact	0.08	0.8	47.71	9.47	0.62	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8536	8536	A	T	MI.1803	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	171	57	K	N	aaA/aaT	6.84	1	0	probably_damaging	0.96	neutral	0.43	neutral	0.68	deleterious	-5.5	deleterious	-4.65	high_impact	3.52	0.74	neutral	0.07	damaging	3.87	23.50	deleterious	0.52641227	0.85	0.73	disease	0.51	disease	0.75	disease	0.65	disease	3	0.96	neutral	0.24	neutral	2	deleterious	0.81	deleterious	-2.07	low_impact	0.22	medium_impact	1.92	medium_impact	0.69	0.85	20.59	8.73	0.63	P	0.70	disease_causing	0.97	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11572	11572	A	C	MI.18030	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	813	271	M	I	atA/atC	7.4	1	0	benign	0.04	neutral	0.39	neutral	4.82	neutral	0.8	deleterious	-3.75	low_impact	1.85	0.7	neutral	0.49	neutral	3.43	23.00	deleterious	0.21	0.45	0.75	disease	0.73	disease	0.51	disease	0.27	neutral	5	0.58	neutral	0.68	deleterious	-6	neutral	0.73	deleterious	0.58	medium_impact	0.09	medium_impact	0.7	medium_impact	0.16	0.8	47.71	9.47	0.57	P	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11572	11572	A	T	MI.18031	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	813	271	M	I	atA/atT	7.4	1	0	benign	0.04	neutral	0.39	neutral	4.82	neutral	0.8	deleterious	-3.75	low_impact	1.85	0.7	neutral	0.49	neutral	3.48	23.10	deleterious	0.21	0.45	0.75	disease	0.73	disease	0.51	disease	0.27	neutral	5	0.58	neutral	0.68	deleterious	-6	neutral	0.73	deleterious	0.58	medium_impact	0.09	medium_impact	0.7	medium_impact	0.16	0.8	47.71	9.47	0.58	P	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11573	11573	A	G	MI.18032	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	814	272	T	A	Aca/Gca	0.72	0.99	0	probably_damaging	1	neutral	0.37	neutral	4.75	neutral	1.92	deleterious	-4.62	low_impact	0.92	0.7	neutral	0.38	neutral	3.45	23.00	deleterious	0.27	0.45	0.55	disease	0.54	disease	0.44	neutral	0.35	neutral	3	1	deleterious	0.19	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.07	medium_impact	-0.22	medium_impact	0.28	0.8	46.19	9.02	0.42	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11573	11573	A	T	MI.18033	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	814	272	T	S	Aca/Tca	0.72	0.99	0	probably_damaging	1	neutral	0.3	neutral	4.64	neutral	-0.84	deleterious	-3.69	low_impact	1.9	0.78	neutral	0.32	neutral	3.29	22.80	deleterious	0.32	0.5	0.71	disease	0.67	disease	0.52	disease	0.48	neutral	0	1	deleterious	0.15	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	0	medium_impact	0.75	medium_impact	0.58	0.8	46.19	9.02	0.44	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11573	11573	A	C	MI.18034	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	814	272	T	P	Aca/Cca	0.72	0.99	0	probably_damaging	1	deleterious	0.02	neutral	4.54	neutral	-2.96	deleterious	-5.59	medium_impact	3.46	0.65	neutral	0.14	damaging	3.50	23.10	deleterious	0.04	0.35	0.8	disease	0.84	disease	0.74	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.75	medium_impact	2.3	high_impact	0.25	0.8	46.19	9.02	0.42	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11574	11574	C	A	MI.18035	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	815	272	T	K	aCa/aAa	6.93	1	0	probably_damaging	1	deleterious	0.03	neutral	4.57	neutral	-2.36	deleterious	-5.58	high_impact	4	0.71	neutral	0.12	damaging	4.53	24.30	deleterious	0.06	0.35	0.81	disease	0.85	disease	0.73	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-0.64	medium_impact	2.83	high_impact	0.31	0.8	46.19	9.02	0.61	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11574	11574	C	T	MI.18036	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	815	272	T	M	aCa/aTa	6.93	1	0	probably_damaging	1	neutral	0.05	neutral	4.57	neutral	-1.41	deleterious	-5.58	medium_impact	2.65	0.71	neutral	0.14	damaging	4.00	23.60	deleterious	0.08	0.35	0.45	neutral	0.76	disease	0.56	disease	0.54	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.52	medium_impact	1.5	medium_impact	0.51	0.8	46.19	9.02	0.55	P	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11576	11576	A	T	MI.18037	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	817	273	S	C	Agc/Tgc	-10.56	0	0	probably_damaging	0.99	deleterious	0.03	neutral	4.09	deleterious	-6.19	deleterious	-4.34	medium_impact	3.28	0.67	neutral	0.35	neutral	3.51	23.10	deleterious	0.06	0.35	0.81	disease	0.8	disease	0.52	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-2.59	low_impact	-0.64	medium_impact	2.12	high_impact	0.28	0.8	46.41	9.21	0.33	N	0.58	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11576	11576	A	G	MI.18038	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	817	273	S	G	Agc/Ggc	-10.56	0	0	benign	0.12	neutral	0.38	neutral	4.31	neutral	-1.44	neutral	-1.97	low_impact	1.53	0.62	neutral	0.62	neutral	1.45	13.05	neutral	0.13	0.4	0.69	disease	0.18	neutral	0.34	neutral	0.37	neutral	3	0.56	neutral	0.63	deleterious	-6	neutral	0.71	deleterious	0.1	medium_impact	0.08	medium_impact	0.39	medium_impact	0.46	0.8	46.41	9.21	0.43	N	0.29	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11576	11576	A	C	MI.18039	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	817	273	S	R	Agc/Cgc	-10.56	0	0	probably_damaging	0.98	deleterious	0	neutral	4.1	deleterious	-4.8	deleterious	-4.16	high_impact	4.32	0.68	neutral	0.33	neutral	3.86	23.50	deleterious	0.04	0.35	0.61	disease	0.87	disease	0.71	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.31	low_impact	-1.48	low_impact	3.15	high_impact	0.41	0.8	46.41	9.21	0.42	N	0.94	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8536	8536	A	C	MI.1804	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	171	57	K	N	aaA/aaC	6.84	1	0	probably_damaging	0.96	neutral	0.43	neutral	0.68	deleterious	-5.5	deleterious	-4.65	high_impact	3.52	0.74	neutral	0.07	damaging	3.80	23.40	deleterious	0.52641227	0.85	0.73	disease	0.51	disease	0.75	disease	0.65	disease	3	0.96	neutral	0.24	neutral	2	deleterious	0.81	deleterious	-2.07	low_impact	0.22	medium_impact	1.92	medium_impact	0.69	0.85	20.59	8.73	0.63	P	0.70	disease_causing	0.97	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11577	11577	G	C	MI.18040	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	818	273	S	T	aGc/aCc	3.71	1	0	probably_damaging	0.92	neutral	0.06	neutral	4.23	neutral	-2.11	deleterious	-2.64	medium_impact	3.08	0.73	neutral	0.42	neutral	3.35	22.90	deleterious	0.23	0.45	0.58	disease	0.59	disease	0.51	disease	0.51	disease	0	0.98	deleterious	0.07	neutral	1	deleterious	0.74	deleterious	-1.71	low_impact	-0.47	medium_impact	1.92	medium_impact	0.48	0.8	46.41	9.21	0.62	P	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11577	11577	G	A	MI.18041	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	818	273	S	N	aGc/aAc	3.71	1	0	probably_damaging	0.94	neutral	0.06	neutral	4.16	neutral	-2.97	neutral	-2.28	medium_impact	2.33	0.67	neutral	0.56	neutral	3.63	23.20	deleterious	0.37	0.5	0.81	disease	0.66	disease	0.44	neutral	0.35	neutral	3	0.99	deleterious	0.06	neutral	1	deleterious	0.79	deleterious	-1.84	low_impact	-0.47	medium_impact	1.18	medium_impact	0.39	0.8	46.41	9.21	0.6	P	0.57	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11577	11577	G	T	MI.18042	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	818	273	S	I	aGc/aTc	3.71	1	0	probably_damaging	0.98	deleterious	0	neutral	4.09	deleterious	-5.66	deleterious	-5.28	high_impact	4.32	0.71	neutral	0.43	neutral	4.12	23.80	deleterious	0.06	0.35	0.51	disease	0.88	disease	0.6	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.31	low_impact	-1.48	low_impact	3.15	high_impact	0.29	0.8	46.41	9.21	0.56	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11579	11579	T	G	MI.18043	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	820	274	S	A	Tcc/Gcc	-1.12	0	0	possibly_damaging	0.72	neutral	0.09	neutral	4.62	neutral	0.43	neutral	-2.15	low_impact	1.92	0.79	neutral	0.6	neutral	3.67	23.30	deleterious	0.25	0.45	0.52	disease	0.45	neutral	0.35	neutral	0.35	neutral	3	0.93	neutral	0.19	neutral	-3	neutral	0.71	deleterious	-1.1	low_impact	-0.36	medium_impact	0.77	medium_impact	0.38	0.8	13.51	9.43	0.37	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11579	11579	T	C	MI.18044	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	820	274	S	P	Tcc/Ccc	-1.12	0	0	probably_damaging	0.98	deleterious	0.02	neutral	4.56	neutral	-2.64	deleterious	-4.13	medium_impact	2.89	0.64	neutral	0.38	neutral	3.99	23.60	deleterious	0.05	0.35	0.87	disease	0.85	disease	0.59	disease	0.67	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.87	deleterious	-2.31	low_impact	-0.75	medium_impact	1.73	medium_impact	0.27	0.8	13.51	9.43	0.31	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	COSM1155512	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11579	11579	T	A	MI.18045	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	820	274	S	T	Tcc/Acc	-1.12	0	0	possibly_damaging	0.85	neutral	0.06	neutral	4.65	neutral	1.06	neutral	-2.26	medium_impact	2.04	0.74	neutral	0.59	neutral	2.77	21.20	deleterious	0.28	0.45	0.37	neutral	0.46	neutral	0.33	neutral	0.42	neutral	2	0.97	neutral	0.11	neutral	0	NA	0.69	deleterious	-1.43	low_impact	-0.47	medium_impact	0.89	medium_impact	0.43	0.8	13.51	9.43	0.48	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11580	11580	C	T	MI.18046	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	821	274	S	F	tCc/tTc	1.41	0.01	0	probably_damaging	0.92	neutral	0.39	neutral	4.67	neutral	0.96	deleterious	-4.69	low_impact	1.08	0.67	neutral	0.51	neutral	4.28	24.00	deleterious	0.1	0.4	0.62	disease	0.71	disease	0.4	neutral	0.28	neutral	4	0.92	neutral	0.24	neutral	-2	neutral	0.77	deleterious	-1.71	low_impact	0.09	medium_impact	-0.06	medium_impact	0.19	0.8	13.51	9.43	0.3	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11580	11580	C	A	MI.18047	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	821	274	S	Y	tCc/tAc	1.41	0.01	0	probably_damaging	0.97	neutral	0.1	neutral	4.57	neutral	-1.26	deleterious	-4.77	medium_impact	2.35	0.76	neutral	0.41	neutral	4.11	23.80	deleterious	0.07	0.35	0.79	disease	0.78	disease	0.44	neutral	0.61	disease	2	0.99	deleterious	0.07	neutral	1	deleterious	0.81	deleterious	-2.14	low_impact	-0.33	medium_impact	1.2	medium_impact	0.22	0.8	13.51	9.43	0.38	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11580	11580	C	G	MI.18048	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	821	274	S	C	tCc/tGc	1.41	0.01	0	probably_damaging	0.98	deleterious	0.03	neutral	4.56	neutral	-2.15	deleterious	-3.56	medium_impact	2.69	0.72	neutral	0.39	neutral	3.58	23.20	deleterious	0.08	0.35	0.87	disease	0.75	disease	0.37	neutral	0.59	disease	2	1	deleterious	0.03	neutral	5	deleterious	0.78	deleterious	-2.31	low_impact	-0.64	medium_impact	1.54	medium_impact	0.26	0.8	13.51	9.43	0.37	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11582	11582	A	C	MI.18049	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	823	275	I	L	Atc/Ctc	-20	0	0	benign	0.33	neutral	0.17	neutral	4.59	neutral	-0.04	neutral	-1.84	medium_impact	2.04	0.76	neutral	0.64	neutral	3.82	23.40	deleterious	0.23	0.45	0.49	neutral	0.57	disease	0.45	neutral	0.2	neutral	6	0.8	neutral	0.42	neutral	-3	neutral	0.65	deleterious	-0.43	medium_impact	-0.18	medium_impact	0.89	medium_impact	0.44	0.8	17.65	17.37	0.39	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8537	8537	A	C	MI.1805	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	172	58	I	L	Atc/Ctc	5.91	1	0.01	possibly_damaging	0.6	neutral	0.48	neutral	1.29	deleterious	-3.11	neutral	-1.78	medium_impact	3.44	1	neutral	0.35	neutral	3.28	22.80	deleterious	0.41111942	0.85	0.36	neutral	0.29	neutral	0.68	disease	0.22	neutral	6	0.59	neutral	0.44	neutral	0	NA	0.39	neutral	-0.92	medium_impact	0.27	medium_impact	1.85	medium_impact	0.80	0.85	NA	NA	0.67	P	0.61	polymorphism	0.98	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11582	11582	A	T	MI.18050	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	823	275	I	F	Atc/Ttc	-20	0	0	probably_damaging	0.9	neutral	0.05	neutral	4.49	neutral	-1.68	deleterious	-3.7	medium_impact	3.04	0.7	neutral	0.39	neutral	3.90	23.50	deleterious	0.16	0.45	0.35	neutral	0.73	disease	0.67	disease	0.66	disease	3	0.98	deleterious	0.08	neutral	1	deleterious	0.72	deleterious	-1.61	low_impact	-0.52	medium_impact	1.88	medium_impact	0.39	0.8	17.65	17.37	0.4	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11582	11582	A	G	MI.18051	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	823	275	I	V	Atc/Gtc	-20	0	0	benign	0.33	neutral	0.17	neutral	4.62	neutral	0.2	neutral	-0.88	low_impact	1.82	0.79	neutral	0.59	neutral	3.01	22.30	deleterious	0.42	0.55	0.45	neutral	0.34	neutral	0.57	disease	0.43	neutral	1	0.8	neutral	0.42	neutral	-6	neutral	0.63	deleterious	-0.43	medium_impact	-0.18	medium_impact	0.68	medium_impact	0.36	0.8	17.65	17.37	0.36	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11583	11583	T	A	MI.18052	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	824	275	I	N	aTc/aAc	4.63	1	0	possibly_damaging	0.83	neutral	0.15	neutral	4.47	deleterious	-3.13	deleterious	-6.43	medium_impact	2.73	0.68	neutral	0.4	neutral	4.43	24.20	deleterious	0.1	0.4	0.92	disease	0.81	disease	0.66	disease	0.69	disease	4	0.92	neutral	0.16	neutral	0	NA	0.82	deleterious	-1.37	low_impact	-0.22	medium_impact	1.58	medium_impact	0.20	0.8	17.65	17.37	0.55	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11583	11583	T	C	MI.18053	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	824	275	I	T	aTc/aCc	4.63	1	0	benign	0.02	neutral	0.12	neutral	4.51	neutral	-1.66	deleterious	-4.49	low_impact	1.46	0.75	neutral	0.68	neutral	2.31	18.20	deleterious	0.11	0.4	0.81	disease	0.57	disease	0.48	neutral	0.37	neutral	3	0.88	neutral	0.55	deleterious	-6	neutral	0.77	deleterious	0.87	medium_impact	-0.28	medium_impact	0.32	medium_impact	0.23	0.8	17.65	17.37	0.51	P	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11583	11583	T	G	MI.18054	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	824	275	I	S	aTc/aGc	4.63	1	0	possibly_damaging	0.56	neutral	0.12	neutral	4.51	neutral	-1.82	deleterious	-5.49	medium_impact	2.6	0.69	neutral	0.43	neutral	4.32	24.00	deleterious	0.04	0.35	0.68	disease	0.82	disease	0.62	disease	0.66	disease	3	0.88	neutral	0.28	neutral	0	NA	0.80	deleterious	-0.82	medium_impact	-0.28	medium_impact	1.45	medium_impact	0.16	0.8	17.65	17.37	0.58	P	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11584	11584	C	G	MI.18055	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	825	275	I	M	atC/atG	4.63	1	0	probably_damaging	0.93	neutral	0.16	neutral	4.51	neutral	-0.93	deleterious	-2.73	medium_impact	2.02	0.77	neutral	0.55	neutral	3.33	22.90	deleterious	0.26	0.45	0.44	neutral	0.6	disease	0.56	disease	0.38	neutral	2	0.96	neutral	0.12	neutral	1	deleterious	0.71	deleterious	-1.77	low_impact	-0.2	medium_impact	0.87	medium_impact	0.44	0.8	17.65	17.37	0.57	P	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11584	11584	C	A	MI.18056	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	825	275	I	M	atC/atA	4.63	1	0	probably_damaging	0.93	neutral	0.16	neutral	4.51	neutral	-0.93	deleterious	-2.73	medium_impact	2.02	0.77	neutral	0.55	neutral	3.70	23.30	deleterious	0.26	0.45	0.44	neutral	0.6	disease	0.56	disease	0.38	neutral	2	0.96	neutral	0.12	neutral	1	deleterious	0.71	deleterious	-1.77	low_impact	-0.2	medium_impact	0.87	medium_impact	0.44	0.8	17.65	17.37	0.58	P	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11585	11585	T	A	MI.18057	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	826	276	C	S	Tgc/Agc	-2.73	0	0	benign	0.03	neutral	0.07	neutral	4.63	neutral	0.36	deleterious	-9.37	high_impact	3.56	0.53	damaging	0.74	neutral	1.57	13.66	neutral	0.08	0.35	0.66	disease	0.87	disease	0.68	disease	0.71	disease	4	0.93	neutral	0.52	deleterious	-2	neutral	0.31	neutral	0.7	medium_impact	-0.43	medium_impact	2.4	high_impact	0.22	0.8	46.41	9.11	0.46	N	0.24	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11585	11585	T	G	MI.18058	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	826	276	C	G	Tgc/Ggc	-2.73	0	0	possibly_damaging	0.48	deleterious	0	neutral	4.83	neutral	1.44	deleterious	-11.25	medium_impact	3.44	0.55	damaging	0.64	neutral	1.37	12.61	neutral	0.07	0.35	0.78	disease	0.89	disease	0.71	disease	0.7	disease	4	1	deleterious	0.26	neutral	4	deleterious	0.33	neutral	-0.69	medium_impact	-1.48	low_impact	2.28	high_impact	0.23	0.8	46.41	9.11	0.4	N	0.75	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11585	11585	T	C	MI.18059	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	826	276	C	R	Tgc/Cgc	-2.73	0	0	possibly_damaging	0.75	deleterious	0	neutral	4.53	neutral	-1.62	deleterious	-11.25	high_impact	4.54	0.57	damaging	0.48	neutral	1.64	14.10	neutral	0.05	0.35	0.78	disease	0.93	disease	0.8	disease	0.73	disease	5	1	deleterious	0.13	neutral	5	deleterious	0.51	deleterious	-1.17	low_impact	-1.48	low_impact	3.37	high_impact	0.09	0.8	46.41	9.11	0.58	P	0.87	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8537	8537	A	G	MI.1806	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	172	58	I	V	Atc/Gtc	5.91	1	0.01	possibly_damaging	0.6	neutral	0.56	neutral	1.35	neutral	-2.67	neutral	-0.83	medium_impact	3.44	1	neutral	0.64	neutral	2.56	19.88	deleterious	0.72936886	0.85	0.25	neutral	0.15	neutral	0.58	disease	0.2	neutral	6	0.55	neutral	0.48	deleterious	0	NA	0.34	neutral	-0.92	medium_impact	0.35	medium_impact	1.85	medium_impact	0.61	0.85	NA	NA	0.63	P	0.15	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11586	11586	G	C	MI.18060	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	827	276	C	S	tGc/tCc	5.78	1	0	benign	0.03	neutral	0.07	neutral	4.63	neutral	0.36	deleterious	-9.37	high_impact	3.56	0.53	damaging	0.74	neutral	1.27	12.12	neutral	0.08	0.35	0.66	disease	0.87	disease	0.68	disease	0.71	disease	4	0.93	neutral	0.52	deleterious	-2	neutral	0.31	neutral	0.7	medium_impact	-0.43	medium_impact	2.4	high_impact	0.22	0.8	46.41	9.11	0.6	P	0.24	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11586	11586	G	A	MI.18061	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	827	276	C	Y	tGc/tAc	5.78	1	0	possibly_damaging	0.85	deleterious	0	neutral	4.53	neutral	-1.08	deleterious	-10.3	high_impact	4.54	0.59	damaging	0.45	neutral	1.96	15.99	deleterious	0.06	0.35	0.57	disease	0.92	disease	0.74	disease	0.74	disease	5	1	deleterious	0.08	neutral	5	deleterious	0.54	deleterious	-1.43	low_impact	-1.48	low_impact	3.37	high_impact	0.27	0.8	46.41	9.11	0.66	P	0.92	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11586	11586	G	T	MI.18062	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	827	276	C	F	tGc/tTc	5.78	1	0	possibly_damaging	0.85	deleterious	0	neutral	4.53	neutral	-0.79	deleterious	-10.3	high_impact	4.54	0.56	damaging	0.51	neutral	2.18	17.37	deleterious	0.05	0.35	0.68	disease	0.93	disease	0.73	disease	0.75	disease	5	1	deleterious	0.08	neutral	5	deleterious	0.51	deleterious	-1.43	low_impact	-1.48	low_impact	3.37	high_impact	0.16	0.8	46.41	9.11	0.65	P	0.94	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11587	11587	C	G	MI.18063	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	828	276	C	W	tgC/tgG	7.4	1	0	probably_damaging	0.92	deleterious	0	neutral	4.52	deleterious	-3.08	deleterious	-10.3	high_impact	4.54	0.59	damaging	0.49	neutral	3.93	23.50	deleterious	0.04	0.35	0.69	disease	0.93	disease	0.79	disease	0.8	disease	6	1	deleterious	0.04	neutral	6	deleterious	0.72	deleterious	-1.71	low_impact	-1.48	low_impact	3.37	high_impact	0.21	0.8	46.41	9.11	0.63	P	0.94	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11587	11587	C	A	MI.18064	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	828	276	C	W	tgC/tgA	7.4	1	0	probably_damaging	0.92	deleterious	0	neutral	4.52	deleterious	-3.08	deleterious	-10.3	high_impact	4.54	0.59	damaging	0.49	neutral	4.26	23.90	deleterious	0.04	0.35	0.69	disease	0.93	disease	0.79	disease	0.8	disease	6	1	deleterious	0.04	neutral	6	deleterious	0.72	deleterious	-1.71	low_impact	-1.48	low_impact	3.37	high_impact	0.21	0.8	46.41	9.11	0.64	P	0.94	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11588	11588	C	A	MI.18065	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	829	277	L	M	Cta/Ata	-1.58	0	0	probably_damaging	1	neutral	0.18	neutral	4.12	deleterious	-3.3	neutral	-1.56	medium_impact	2.4	0.79	neutral	0.7	neutral	2.66	20.60	deleterious	0.19	0.45	0.69	disease	0.36	neutral	0.44	neutral	0.6	disease	2	1	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.17	medium_impact	1.25	medium_impact	0.54	0.8	42.05	7.89	0.39	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11588	11588	C	G	MI.18066	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	829	277	L	V	Cta/Gta	-1.58	0	0	probably_damaging	1	neutral	0.08	neutral	4.11	neutral	-2	deleterious	-2.65	medium_impact	2.82	0.68	neutral	0.16	damaging	3.45	23.00	deleterious	0.19	0.45	0.37	neutral	0.61	disease	0.61	disease	0.54	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.39	medium_impact	1.66	medium_impact	0.51	0.8	42.05	7.89	0.32	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11589	11589	T	A	MI.18067	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	830	277	L	Q	cTa/cAa	-4.81	0	0	probably_damaging	1	deleterious	0	neutral	4.02	deleterious	-5.82	deleterious	-5.34	high_impact	4.37	0.65	neutral	0.14	damaging	4.10	23.70	deleterious	0.03	0.35	0.91	disease	0.8	disease	0.68	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.2	high_impact	0.31	0.8	42.05	7.89	0.35	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11589	11589	T	G	MI.18068	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	830	277	L	R	cTa/cGa	-4.81	0	0	probably_damaging	1	deleterious	0	neutral	4.03	deleterious	-5.49	deleterious	-5.4	high_impact	4.37	0.59	damaging	0.13	damaging	4.23	23.90	deleterious	0.02	0.35	0.9	disease	0.88	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.2	high_impact	0.20	0.8	42.05	7.89	0.43	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11589	11589	T	C	MI.18069	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	830	277	L	P	cTa/cCa	-4.81	0	0	probably_damaging	1	deleterious	0	neutral	4.02	deleterious	-5.9	deleterious	-6.33	high_impact	4.37	0.52	damaging	0.14	damaging	3.93	23.50	deleterious	0.03	0.35	0.93	disease	0.85	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.2	high_impact	0.34	0.8	42.05	7.89	0.42	N	0.98	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8537	8537	A	T	MI.1807	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	172	58	I	F	Atc/Ttc	5.91	1	0.01	possibly_damaging	0.9	neutral	0.45	neutral	1.22	deleterious	-5.38	deleterious	-3.53	medium_impact	3.44	1	neutral	0.37	neutral	3.59	23.20	deleterious	0.31771780	0.85	0.68	disease	0.35	neutral	0.72	disease	0.32	neutral	4	0.9	neutral	0.28	neutral	0	NA	0.69	deleterious	-1.66	low_impact	0.24	medium_impact	1.85	medium_impact	0.70	0.85	NA	NA	0.71	P	0.57	disease_causing	0.66	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11591	11591	C	T	MI.18070	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	832	278	R	W	Cga/Tga	-3.19	0	0	probably_damaging	1	deleterious	0.04	neutral	4.54	deleterious	-3.64	deleterious	-7.5	high_impact	3.81	0.62	neutral	0.19	damaging	5.21	25.50	deleterious	0.05	0.35	0.88	disease	0.88	disease	0.7	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-0.57	medium_impact	2.64	high_impact	0.76	0.85	47.06	9.55	0.34	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11591	11591	C	G	MI.18071	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	832	278	R	G	Cga/Gga	-3.19	0	0	probably_damaging	1	neutral	0.08	neutral	4.6	neutral	-0.5	deleterious	-6.56	medium_impact	3	0.62	neutral	0.36	neutral	4.27	24.00	deleterious	0.05	0.35	0.61	disease	0.81	disease	0.73	disease	0.62	disease	2	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.39	medium_impact	1.84	medium_impact	0.28	0.8	47.06	9.55	0.31	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11592	11592	G	C	MI.18072	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	833	278	R	P	cGa/cCa	7.17	1	0	probably_damaging	1	deleterious	0.03	neutral	4.55	neutral	-2.93	deleterious	-6.56	high_impact	4.35	0.59	damaging	0.25	damaging	4.28	24.00	deleterious	0.03	0.35	0.83	disease	0.89	disease	0.81	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-0.64	medium_impact	3.18	high_impact	0.17	0.8	47.06	9.55	0.66	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11592	11592	G	A	MI.18073	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	833	278	R	Q	cGa/cAa	7.17	1	0	probably_damaging	1	neutral	0.08	neutral	4.61	neutral	-1.94	deleterious	-3.73	medium_impact	2.6	0.68	neutral	0.31	neutral	4.61	24.40	deleterious	0.17	0.45	0.79	disease	0.77	disease	0.48	neutral	0.29	neutral	4	1	deleterious	0.04	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	-0.39	medium_impact	1.45	medium_impact	0.65	0.8	47.06	9.55	0.63	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11592	11592	G	T	MI.18074	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	833	278	R	L	cGa/cTa	7.17	1	0	probably_damaging	1	neutral	0.14	neutral	4.58	neutral	-0.69	deleterious	-6.56	medium_impact	2.86	0.66	neutral	0.31	neutral	4.38	24.10	deleterious	0.06	0.35	0.37	neutral	0.9	disease	0.67	disease	0.72	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.24	medium_impact	1.7	medium_impact	0.13	0.8	47.06	9.55	0.57	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11594	11594	C	A	MI.18075	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	835	279	Q	K	Caa/Aaa	-12.63	0	0	benign	0.08	deleterious	0	neutral	4.11	deleterious	-3.51	deleterious	-3.8	medium_impact	3.46	0.57	damaging	0.31	neutral	3.96	23.60	deleterious	0.09	0.35	0.77	disease	0.86	disease	0.76	disease	0.71	disease	4	1	deleterious	0.46	neutral	1	deleterious	0.84	deleterious	0.28	medium_impact	-1.48	low_impact	2.3	high_impact	0.24	0.8	47.06	9.25	0.32	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11594	11594	C	G	MI.18076	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	835	279	Q	E	Caa/Gaa	-12.63	0	0	possibly_damaging	0.64	neutral	0.05	neutral	4.15	deleterious	-3.45	deleterious	-2.85	high_impact	3.63	0.66	neutral	0.38	neutral	3.10	22.50	deleterious	0.15	0.4	0.8	disease	0.78	disease	0.74	disease	0.71	disease	4	0.95	neutral	0.21	neutral	1	deleterious	0.83	deleterious	-0.95	medium_impact	-0.52	medium_impact	2.47	high_impact	0.24	0.8	47.06	9.25	0.37	N	0.93	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11595	11595	A	G	MI.18077	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	836	279	Q	R	cAa/cGa	4.4	1	0	possibly_damaging	0.74	deleterious	0	neutral	4.07	deleterious	-4.29	deleterious	-3.8	high_impact	4.61	0.55	damaging	0.32	neutral	3.25	22.80	deleterious	0.11	0.4	0.77	disease	0.86	disease	0.81	disease	0.73	disease	5	1	deleterious	0.13	neutral	5	deleterious	0.85	deleterious	-1.14	low_impact	-1.48	low_impact	3.44	high_impact	0.19	0.8	47.06	9.25	0.67	P	0.88	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11595	11595	A	C	MI.18078	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	836	279	Q	P	cAa/cCa	4.4	1	0	probably_damaging	0.96	deleterious	0	neutral	4.03	deleterious	-6.27	deleterious	-5.7	high_impact	4.61	0.63	neutral	0.42	neutral	3.16	22.60	deleterious	0.03	0.35	0.71	disease	0.88	disease	0.83	disease	0.77	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-2.01	low_impact	-1.48	low_impact	3.44	high_impact	0.11	0.8	47.06	9.25	0.63	P	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11595	11595	A	T	MI.18079	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	836	279	Q	L	cAa/cTa	4.4	1	0	possibly_damaging	0.88	deleterious	0.01	neutral	4.08	deleterious	-5.68	deleterious	-6.66	medium_impact	3.08	0.6	damaging	0.4	neutral	3.60	23.20	deleterious	0.03	0.35	0.5	neutral	0.89	disease	0.72	disease	0.72	disease	4	1	deleterious	0.07	neutral	4	deleterious	0.80	deleterious	-1.53	low_impact	-0.92	medium_impact	1.92	medium_impact	0.12	0.8	47.06	9.25	0.51	P	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8538	8538	T	G	MI.1808	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	173	58	I	S	aTc/aGc	1.75	0.93	0	possibly_damaging	0.9	neutral	0.39	neutral	1.24	deleterious	-5.9	deleterious	-5.04	medium_impact	3.1	1	neutral	0.35	neutral	4.26	23.90	deleterious	0.30623305	0.85	0.69	disease	0.54	disease	0.7	disease	0.65	disease	3	0.9	neutral	0.25	neutral	0	NA	0.73	deleterious	-1.66	low_impact	0.18	medium_impact	1.56	medium_impact	0.44	0.85	NA	NA	0.55	P	0.47	polymorphism	0.97	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11596	11596	A	C	MI.18080	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	837	279	Q	H	caA/caC	6.7	1	0	probably_damaging	0.98	deleterious	0	neutral	4.04	deleterious	-5.85	deleterious	-4.75	high_impact	3.91	0.59	damaging	0.32	neutral	3.44	23.00	deleterious	0.07	0.35	0.82	disease	0.8	disease	0.82	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.31	low_impact	-1.48	low_impact	2.74	high_impact	0.40	0.8	47.06	9.25	0.63	P	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11596	11596	A	T	MI.18081	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	837	279	Q	H	caA/caT	6.7	1	0	probably_damaging	0.98	deleterious	0	neutral	4.04	deleterious	-5.85	deleterious	-4.75	high_impact	3.91	0.59	damaging	0.32	neutral	3.59	23.20	deleterious	0.07	0.35	0.82	disease	0.8	disease	0.82	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.31	low_impact	-1.48	low_impact	2.74	high_impact	0.40	0.8	47.06	9.25	0.63	P	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11597	11597	A	G	MI.18082	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	838	280	T	A	Aca/Gca	4.63	1	0	benign	0.12	neutral	0.05	neutral	4.46	neutral	-1.82	deleterious	-3.99	medium_impact	2.23	0.7	neutral	0.69	neutral	3.36	22.90	deleterious	0.24	0.45	0.63	disease	0.5	neutral	0.5	neutral	0.31	neutral	4	0.94	neutral	0.47	neutral	-3	neutral	0.75	deleterious	0.1	medium_impact	-0.52	medium_impact	1.08	medium_impact	0.28	0.8	13.94	14.75	0.58	P	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11597	11597	A	C	MI.18083	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	838	280	T	P	Aca/Cca	4.63	1	0	probably_damaging	0.96	deleterious	0.02	neutral	4.4	deleterious	-3.37	deleterious	-5.25	low_impact	1.75	0.64	neutral	0.52	neutral	3.52	23.10	deleterious	0.03	0.35	0.82	disease	0.78	disease	0.61	disease	0.51	disease	0	1	deleterious	0.03	neutral	2	deleterious	0.84	deleterious	-2.01	low_impact	-0.75	medium_impact	0.61	medium_impact	0.19	0.8	13.94	14.75	0.48	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11597	11597	A	T	MI.18084	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	838	280	T	S	Aca/Tca	4.63	1	0	possibly_damaging	0.74	neutral	0.32	neutral	4.54	neutral	-1.05	deleterious	-3.39	low_impact	1.81	0.73	neutral	0.57	neutral	3.24	22.80	deleterious	0.43	0.55	0.62	disease	0.62	disease	0.33	neutral	0.24	neutral	5	0.79	neutral	0.29	neutral	-3	neutral	0.77	deleterious	-1.14	low_impact	0.02	medium_impact	0.67	medium_impact	0.57	0.8	13.94	14.75	0.58	P	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11598	11598	C	T	MI.18085	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	839	280	T	M	aCa/aTa	4.63	1	0	probably_damaging	0.98	neutral	0.06	neutral	4.42	deleterious	-4.23	deleterious	-5.2	medium_impact	2.66	0.71	neutral	0.56	neutral	4.05	23.70	deleterious	0.1	0.4	0.88	disease	0.75	disease	0.52	disease	0.6	disease	2	1	deleterious	0.04	neutral	1	deleterious	0.79	deleterious	-2.31	low_impact	-0.47	medium_impact	1.51	medium_impact	0.38	0.8	13.94	14.75	0.57	P	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11598	11598	C	A	MI.18086	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	839	280	T	K	aCa/aAa	4.63	1	0	benign	0.12	deleterious	0.01	neutral	4.44	neutral	-0.61	deleterious	-5.25	medium_impact	2.47	0.69	neutral	0.4	neutral	4.56	24.40	deleterious	0.08	0.35	0.57	disease	0.83	disease	0.62	disease	0.66	disease	3	0.99	deleterious	0.45	neutral	1	deleterious	0.81	deleterious	0.1	medium_impact	-0.92	medium_impact	1.32	medium_impact	0.33	0.8	13.94	14.75	0.48	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11600	11600	G	A	MI.18087	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	841	281	D	N	Gac/Aac	-2.96	0	0	probably_damaging	0.94	deleterious	0	neutral	4.27	neutral	-2.49	deleterious	-4.72	medium_impact	3.33	0.41	damaging	0.39	neutral	4.23	23.90	deleterious	0.25	0.45	0.77	disease	0.76	disease	0.72	disease	0.7	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.81	deleterious	-1.84	low_impact	-1.48	low_impact	2.17	high_impact	0.86	0.9	47.71	9.41	0.56	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	COSM6716737	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11600	11600	G	T	MI.18088	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	841	281	D	Y	Gac/Tac	-2.96	0	0	probably_damaging	0.99	deleterious	0	neutral	4.16	deleterious	-6.78	deleterious	-8.51	high_impact	4.64	0.43	damaging	0.28	neutral	3.92	23.50	deleterious	0.02	0.35	0.71	disease	0.89	disease	0.77	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.59	low_impact	-1.48	low_impact	3.46	high_impact	0.11	0.8	47.71	9.41	0.62	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11600	11600	G	C	MI.18089	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	841	281	D	H	Gac/Cac	-2.96	0	0	probably_damaging	0.99	deleterious	0	neutral	4.18	deleterious	-4.9	deleterious	-6.61	high_impact	3.96	0.41	damaging	0.28	neutral	3.68	23.30	deleterious	0.04	0.35	0.81	disease	0.8	disease	0.77	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.59	low_impact	-1.48	low_impact	2.79	high_impact	0.42	0.8	47.71	9.41	0.61	P	0.99	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8538	8538	T	A	MI.1809	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	173	58	I	N	aTc/aAc	1.75	0.93	0	probably_damaging	0.97	neutral	0.17	neutral	1.21	deleterious	-6.9	deleterious	-6.05	medium_impact	3.44	1	neutral	0.37	neutral	4.65	24.50	deleterious	0.29671997	0.85	0.82	disease	0.62	disease	0.71	disease	0.65	disease	3	0.98	deleterious	0.1	neutral	1	deleterious	0.79	deleterious	-2.19	low_impact	-0.1	medium_impact	1.85	medium_impact	0.51	0.85	NA	NA	0.58	P	0.72	polymorphism	0.98	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11601	11601	A	C	MI.18090	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	842	281	D	A	gAc/gCc	6.01	1	0	probably_damaging	0.91	deleterious	0	neutral	4.22	deleterious	-4.51	deleterious	-7.56	high_impact	4.3	0.49	damaging	0.4	neutral	3.65	23.20	deleterious	0.04	0.35	0.39	neutral	0.73	disease	0.73	disease	0.68	disease	4	1	deleterious	0.05	neutral	6	deleterious	0.77	deleterious	-1.66	low_impact	-1.48	low_impact	3.13	high_impact	0.18	0.8	47.71	9.41	0.58	P	0.93	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11601	11601	A	G	MI.18091	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	842	281	D	G	gAc/gGc	6.01	1	0	probably_damaging	0.95	deleterious	0	neutral	4.18	deleterious	-5.23	deleterious	-6.62	high_impact	4.64	0.41	damaging	0.38	neutral	3.99	23.60	deleterious	0.04	0.35	0.68	disease	0.84	disease	0.73	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-1.92	low_impact	-1.48	low_impact	3.46	high_impact	0.25	0.8	47.71	9.41	0.78	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11601	11601	A	T	MI.18092	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	842	281	D	V	gAc/gTc	6.01	1	0	probably_damaging	0.98	deleterious	0	neutral	4.18	deleterious	-5.77	deleterious	-8.51	high_impact	4.64	0.39	damaging	0.33	neutral	3.76	23.30	deleterious	0.02	0.35	0.35	neutral	0.86	disease	0.73	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.31	low_impact	-1.48	low_impact	3.46	high_impact	0.13	0.8	47.71	9.41	0.72	P	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11602	11602	C	A	MI.18093	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	843	281	D	E	gaC/gaA	8.55	1	0	benign	0.22	deleterious	0	neutral	4.25	deleterious	-3.48	deleterious	-3.78	high_impact	4.09	0.41	damaging	0.35	neutral	4.29	24.00	deleterious	0.11	0.4	0.78	disease	0.73	disease	0.67	disease	0.67	disease	3	1	deleterious	0.39	neutral	2	deleterious	0.83	deleterious	-0.2	medium_impact	-1.48	low_impact	2.92	high_impact	0.44	0.8	47.71	9.41	0.74	P	0.95	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11602	11602	C	G	MI.18094	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	843	281	D	E	gaC/gaG	8.55	1	0	benign	0.22	deleterious	0	neutral	4.25	deleterious	-3.48	deleterious	-3.78	high_impact	4.09	0.41	damaging	0.35	neutral	3.96	23.60	deleterious	0.11	0.4	0.78	disease	0.73	disease	0.67	disease	0.67	disease	3	1	deleterious	0.39	neutral	2	deleterious	0.83	deleterious	-0.2	medium_impact	-1.48	low_impact	2.92	high_impact	0.44	0.8	47.71	9.41	0.73	P	0.95	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11603	11603	C	A	MI.18095	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	844	282	L	M	Cta/Ata	-0.89	0	0	probably_damaging	1	neutral	0.25	neutral	4.45	neutral	-2.06	neutral	-1.83	low_impact	1.85	0.73	neutral	0.48	neutral	3.93	23.50	deleterious	0.31	0.45	0.53	disease	0.38	neutral	0.44	neutral	0.32	neutral	4	1	deleterious	0.13	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	-0.07	medium_impact	0.7	medium_impact	0.66	0.8	44.88	8.38	0.4	N	0.90	polymorphism	1	0.02	rs28669780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11603	11603	C	G	MI.18096	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	844	282	L	V	Cta/Gta	-0.89	0	0	probably_damaging	1	neutral	0.16	neutral	4.5	neutral	-1.23	deleterious	-2.81	medium_impact	2.52	0.65	neutral	0.13	damaging	3.46	23.00	deleterious	0.27	0.45	0.43	neutral	0.5	disease	0.59	disease	0.56	disease	1	1	deleterious	0.08	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.2	medium_impact	1.37	medium_impact	0.56	0.8	44.88	8.38	0.32	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11604	11604	T	A	MI.18097	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	845	282	L	Q	cTa/cAa	-0.66	0	0	probably_damaging	1	deleterious	0.02	neutral	4.34	deleterious	-5.19	deleterious	-5.63	high_impact	3.67	0.59	damaging	0.1	damaging	4.18	23.80	deleterious	0.04	0.35	0.75	disease	0.74	disease	0.61	disease	0.64	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.75	medium_impact	2.51	high_impact	0.19	0.8	44.88	8.38	0.27	N	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11604	11604	T	C	MI.18098	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	845	282	L	P	cTa/cCa	-0.66	0	0	probably_damaging	1	deleterious	0	neutral	4.34	deleterious	-4.76	deleterious	-6.59	high_impact	4.36	0.54	damaging	0.1	damaging	3.97	23.60	deleterious	0.03	0.35	0.92	disease	0.77	disease	0.73	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.19	high_impact	0.30	0.8	44.88	8.38	0.37	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11604	11604	T	G	MI.18099	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	845	282	L	R	cTa/cGa	-0.66	0	0	probably_damaging	1	deleterious	0	neutral	4.35	deleterious	-5.02	deleterious	-5.64	high_impact	4.36	0.56	damaging	0.09	damaging	4.23	23.90	deleterious	0.03	0.35	0.89	disease	0.79	disease	0.73	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.19	high_impact	0.09	0.8	44.88	8.38	0.38	N	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8611	8611	C	G	MI.181	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	85	29	L	V	Cta/Gta	-6.12	0	0	probably_damaging	0.99	neutral	0.19	neutral	4.36	neutral	-0.63	neutral	-0.68	low_impact	0.9	0.89	neutral	0.88	neutral	1.75	14.67	neutral	0.46	0.65	0.3	neutral	0.26	neutral	0.39	neutral	0.44	neutral	1	0.99	deleterious	0.1	neutral	-2	neutral	0.70	deleterious	-2.65	low_impact	-0.06	medium_impact	-0.33	medium_impact	0.70	0.9	17.26	17.02	0.48	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8538	8538	T	C	MI.1810	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	173	58	I	T	aTc/aCc	1.75	0.93	0	possibly_damaging	0.9	neutral	0.48	neutral	1.28	deleterious	-5.35	deleterious	-4.13	medium_impact	2	1	neutral	0.82	neutral	2.28	18.03	deleterious	0.46155204	0.85	0.5	neutral	0.39	neutral	0.43	neutral	0.12	neutral	8	0.89	neutral	0.29	neutral	0	NA	0.67	deleterious	-1.66	low_impact	0.27	medium_impact	0.62	medium_impact	0.58	0.85	NA	NA	0.52	N	0.18	polymorphism	0.99	0.14	rs878853010	Uncertain_significance	not_provided	237013	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11606	11606	A	G	MI.18100	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	847	283	K	E	Aaa/Gaa	0.72	0.99	0	probably_damaging	1	deleterious	0	neutral	3.18	deleterious	-6.61	deleterious	-3.78	high_impact	4.63	0.52	damaging	0.07	damaging	4.08	23.70	deleterious	0.03	0.35	0.54	disease	0.85	disease	0.76	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.28	0.8	47.06	9.38	0.55	P	0.87	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11606	11606	A	C	MI.18101	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	847	283	K	Q	Aaa/Caa	0.72	0.99	0	probably_damaging	1	deleterious	0	neutral	3.2	deleterious	-5.9	deleterious	-3.78	high_impact	4.63	0.52	damaging	0.07	damaging	3.53	23.10	deleterious	0.09	0.35	0.62	disease	0.8	disease	0.73	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.31	0.8	47.06	9.38	0.54	P	0.86	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11607	11607	A	C	MI.18102	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	848	283	K	T	aAa/aCa	8.55	1	0	probably_damaging	1	deleterious	0	neutral	3.17	deleterious	-7.12	deleterious	-5.67	high_impact	4.08	0.52	damaging	0.07	damaging	3.65	23.20	deleterious	0.04	0.35	0.39	neutral	0.8	disease	0.73	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	2.91	high_impact	0.11	0.8	47.06	9.38	0.54	P	0.77	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11607	11607	A	T	MI.18103	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	848	283	K	M	aAa/aTa	8.55	1	0	probably_damaging	1	deleterious	0	neutral	3.16	deleterious	-8.56	deleterious	-5.68	high_impact	4.63	0.55	damaging	0.06	damaging	3.90	23.50	deleterious	0.03	0.35	0.84	disease	0.83	disease	0.72	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.12	0.8	47.06	9.38	0.57	P	0.42	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11608	11608	A	T	MI.18104	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	849	283	K	N	aaA/aaT	8.55	1	0	probably_damaging	1	deleterious	0	neutral	3.17	deleterious	-6.97	deleterious	-4.73	high_impact	4.63	0.51	damaging	0.07	damaging	3.96	23.60	deleterious	0.07	0.35	0.56	disease	0.79	disease	0.74	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.20	0.8	47.06	9.38	0.56	P	0.72	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11608	11608	A	C	MI.18105	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	849	283	K	N	aaA/aaC	8.55	1	0	probably_damaging	1	deleterious	0	neutral	3.17	deleterious	-6.97	deleterious	-4.73	high_impact	4.63	0.51	damaging	0.07	damaging	3.89	23.50	deleterious	0.07	0.35	0.56	disease	0.79	disease	0.74	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.20	0.8	47.06	9.38	0.56	P	0.72	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11609	11609	T	A	MI.18106	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	850	284	S	T	Tcg/Acg	0.95	1	0	benign	0.2	neutral	0.07	neutral	4.6	neutral	-0.35	deleterious	-2.82	medium_impact	3.08	0.67	neutral	0.44	neutral	3.95	23.60	deleterious	0.33	0.5	0.64	disease	0.63	disease	0.61	disease	0.64	disease	3	0.92	neutral	0.44	neutral	-3	neutral	0.76	deleterious	-0.15	medium_impact	-0.43	medium_impact	1.92	medium_impact	0.61	0.8	44.23	8.56	0.52	P	0.73	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11609	11609	T	C	MI.18107	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	850	284	S	P	Tcg/Ccg	0.95	1	0	probably_damaging	0.94	deleterious	0.01	neutral	4.56	neutral	-2.09	deleterious	-4.71	high_impact	4.12	0.67	neutral	0.44	neutral	4.08	23.70	deleterious	0.04	0.35	0.8	disease	0.83	disease	0.75	disease	0.73	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.85	deleterious	-1.84	low_impact	-0.92	medium_impact	2.95	high_impact	0.20	0.8	44.23	8.56	0.5	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11609	11609	T	G	MI.18108	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	850	284	S	A	Tcg/Gcg	0.95	1	0	benign	0.08	neutral	0.33	neutral	4.67	neutral	0.32	deleterious	-2.79	low_impact	0.96	0.8	neutral	0.68	neutral	3.72	23.30	deleterious	0.35	0.5	0.6	disease	0.31	neutral	0.4	neutral	0.53	disease	1	0.63	neutral	0.63	deleterious	-6	neutral	0.73	deleterious	0.28	medium_impact	0.03	medium_impact	-0.18	medium_impact	0.42	0.8	44.23	8.56	0.39	N	0.51	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11610	11610	C	T	MI.18109	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	851	284	S	L	tCg/tTg	3.71	1	0	possibly_damaging	0.74	neutral	0.06	neutral	4.57	neutral	-0.53	deleterious	-5.65	medium_impact	2.69	0.7	neutral	0.48	neutral	4.65	24.50	deleterious	0.08	0.35	0.64	disease	0.83	disease	0.59	disease	0.6	disease	2	0.95	neutral	0.16	neutral	0	NA	0.75	deleterious	-1.14	low_impact	-0.47	medium_impact	1.54	medium_impact	0.33	0.8	44.23	8.56	0.6	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8539	8539	C	A	MI.1811	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	174	58	I	M	atC/atA	-0.33	0	0	probably_damaging	0.96	neutral	0.28	neutral	1.22	deleterious	-5.22	deleterious	-2.66	medium_impact	3.44	0.99	neutral	0.32	neutral	3.74	23.30	deleterious	0.46889253	0.85	0.64	disease	0.27	neutral	0.71	disease	0.22	neutral	6	0.97	neutral	0.16	neutral	1	deleterious	0.72	deleterious	-2.07	low_impact	0.06	medium_impact	1.85	medium_impact	0.77	0.85	NA	NA	0.5	N	0.57	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11610	11610	C	G	MI.18110	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	851	284	S	W	tCg/tGg	3.71	1	0	probably_damaging	0.99	deleterious	0	neutral	4.54	deleterious	-3.8	deleterious	-6.6	high_impact	4.12	0.69	neutral	0.44	neutral	4.37	24.10	deleterious	0.05	0.35	0.65	disease	0.88	disease	0.67	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.59	low_impact	-1.48	low_impact	2.95	high_impact	0.13	0.8	44.23	8.56	0.55	P	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11612	11612	C	A	MI.18111	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	853	285	L	I	Ctc/Atc	-6.42	0	0	probably_damaging	1	neutral	0.09	neutral	4.52	neutral	-1.43	neutral	-1.86	low_impact	1.88	0.67	neutral	0.53	neutral	4.12	23.80	deleterious	0.29	0.45	0.52	disease	0.59	disease	0.57	disease	0.53	disease	1	1	deleterious	0.05	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	-0.36	medium_impact	0.73	medium_impact	0.53	0.8	47.49	9.22	0.37	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11612	11612	C	G	MI.18112	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	853	285	L	V	Ctc/Gtc	-6.42	0	0	probably_damaging	1	deleterious	0	neutral	4.55	neutral	-0.98	deleterious	-2.78	medium_impact	3.12	0.64	neutral	0.45	neutral	3.48	23.10	deleterious	0.23	0.45	0.51	disease	0.58	disease	0.67	disease	0.65	disease	3	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.54	low_impact	-1.48	low_impact	1.96	medium_impact	0.48	0.8	47.49	9.22	0.38	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11612	11612	C	T	MI.18113	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	853	285	L	F	Ctc/Ttc	-6.42	0	0	probably_damaging	1	deleterious	0.03	neutral	4.33	deleterious	-3.7	deleterious	-3.73	medium_impact	3.08	0.65	neutral	0.38	neutral	4.01	23.60	deleterious	0.13	0.4	0.69	disease	0.68	disease	0.67	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.54	low_impact	-0.64	medium_impact	1.92	medium_impact	0.52	0.8	47.49	9.22	0.3	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11613	11613	T	C	MI.18114	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	854	285	L	P	cTc/cCc	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.28	deleterious	-5.88	deleterious	-6.54	high_impact	4.36	0.54	damaging	0.33	neutral	3.94	23.50	deleterious	0.02	0.35	0.36	neutral	0.79	disease	0.77	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.19	high_impact	0.27	0.8	47.49	9.22	0.47	N	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11613	11613	T	G	MI.18115	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	854	285	L	R	cTc/cGc	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.32	deleterious	-3.43	deleterious	-5.59	high_impact	3.55	0.66	neutral	0.29	neutral	4.24	23.90	deleterious	0.01	0.35	0.83	disease	0.83	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.39	high_impact	0.10	0.8	47.49	9.22	0.34	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11613	11613	T	A	MI.18116	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	854	285	L	H	cTc/cAc	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.28	deleterious	-5.83	deleterious	-6.54	high_impact	4.36	0.63	neutral	0.31	neutral	4.17	23.80	deleterious	0.04	0.35	0.71	disease	0.77	disease	0.74	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.19	high_impact	0.23	0.8	47.49	9.22	0.4	N	0.96	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11615	11615	A	C	MI.18117	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	856	286	I	L	Att/Ctt	-5.5	0	0	possibly_damaging	0.61	neutral	0.06	neutral	4.68	neutral	0.11	neutral	-1.89	medium_impact	3.5	0.52	damaging	0.45	neutral	3.82	23.40	deleterious	0.27	0.45	0.36	neutral	0.65	disease	0.64	disease	0.66	disease	3	0.94	neutral	0.23	neutral	0	NA	0.66	deleterious	-0.9	medium_impact	-0.47	medium_impact	2.34	high_impact	0.55	0.8	47.28	9.54	0.5	P	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11615	11615	A	G	MI.18118	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	856	286	I	V	Att/Gtt	-5.5	0	0	benign	0.12	neutral	0.15	neutral	4.39	neutral	-1.17	neutral	-0.94	medium_impact	2.01	0.58	damaging	0.49	neutral	3.09	22.50	deleterious	0.34	0.5	0.47	neutral	0.44	neutral	0.61	disease	0.43	neutral	1	0.83	neutral	0.52	deleterious	-3	neutral	0.64	deleterious	0.1	medium_impact	-0.22	medium_impact	0.86	medium_impact	0.49	0.8	47.28	9.54	0.44	N	0.75	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11615	11615	A	T	MI.18119	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	856	286	I	F	Att/Ttt	-5.5	0	0	probably_damaging	0.97	deleterious	0	neutral	4.17	deleterious	-4.33	deleterious	-3.78	high_impact	4.13	0.57	damaging	0.4	neutral	3.81	23.40	deleterious	0.04	0.35	0.56	disease	0.79	disease	0.7	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.14	low_impact	-1.48	low_impact	2.96	high_impact	0.56	0.8	47.28	9.54	0.42	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8539	8539	C	G	MI.1812	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	174	58	I	M	atC/atG	-0.33	0	0	probably_damaging	0.96	neutral	0.28	neutral	1.22	deleterious	-5.22	deleterious	-2.66	medium_impact	3.44	0.99	neutral	0.32	neutral	3.38	22.90	deleterious	0.46889253	0.85	0.64	disease	0.27	neutral	0.71	disease	0.22	neutral	6	0.97	neutral	0.16	neutral	1	deleterious	0.72	deleterious	-2.07	low_impact	0.06	medium_impact	1.85	medium_impact	0.77	0.85	NA	NA	0.5	N	0.57	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11616	11616	T	G	MI.18120	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	857	286	I	S	aTt/aGt	8.55	1	0	probably_damaging	0.96	deleterious	0	neutral	4.16	deleterious	-5.21	deleterious	-5.67	high_impact	4.47	0.58	damaging	0.51	neutral	4.30	24.00	deleterious	0.02	0.35	0.65	disease	0.84	disease	0.66	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.76	deleterious	-2.01	low_impact	-1.48	low_impact	3.3	high_impact	0.23	0.8	47.28	9.54	0.56	P	0.95	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11616	11616	T	A	MI.18121	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	857	286	I	N	aTt/aAt	8.55	1	0	probably_damaging	0.98	deleterious	0	neutral	4.15	deleterious	-6.38	deleterious	-6.62	high_impact	3.78	0.54	damaging	0.41	neutral	4.43	24.20	deleterious	0.03	0.35	0.66	disease	0.83	disease	0.7	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.31	low_impact	-1.48	low_impact	2.61	high_impact	0.28	0.8	47.28	9.54	0.55	P	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11616	11616	T	C	MI.18122	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	857	286	I	T	aTt/aCt	8.55	1	0	probably_damaging	0.91	deleterious	0	neutral	4.17	deleterious	-4.48	deleterious	-4.73	high_impact	3.58	0.59	damaging	0.41	neutral	3.40	23.00	deleterious	0.03	0.35	0.42	neutral	0.72	disease	0.63	disease	0.66	disease	3	1	deleterious	0.05	neutral	6	deleterious	0.74	deleterious	-1.66	low_impact	-1.48	low_impact	2.42	high_impact	0.17	0.8	47.28	9.54	0.56	P	0.96	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11617	11617	T	G	MI.18123	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	858	286	I	M	atT/atG	7.4	1	0	probably_damaging	0.97	deleterious	0.01	neutral	4.28	neutral	-2.04	deleterious	-2.83	high_impact	3.67	0.56	damaging	0.54	neutral	3.45	23.00	deleterious	0.08	0.35	0.45	neutral	0.68	disease	0.64	disease	0.65	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.72	deleterious	-2.14	low_impact	-0.92	medium_impact	2.51	high_impact	0.48	0.8	47.28	9.54	0.63	P	0.76	polymorphism	1	0.16	rs386829135	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11617	11617	T	A	MI.18124	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	858	286	I	M	atT/atA	7.4	1	0	probably_damaging	0.97	deleterious	0.01	neutral	4.28	neutral	-2.04	deleterious	-2.83	high_impact	3.67	0.56	damaging	0.54	neutral	3.73	23.30	deleterious	0.08	0.35	0.45	neutral	0.68	disease	0.64	disease	0.65	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.72	deleterious	-2.14	low_impact	-0.92	medium_impact	2.51	high_impact	0.48	0.8	47.28	9.54	0.63	P	0.76	polymorphism	1	0.16	rs386829135	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11618	11618	G	C	MI.18125	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	859	287	A	P	Gca/Cca	-4.35	0	0	probably_damaging	1	deleterious	0	neutral	2.89	deleterious	-9.47	deleterious	-4.73	high_impact	4.63	0.55	damaging	0.1	damaging	3.87	23.50	deleterious	0.01	0.35	0.9	disease	0.87	disease	0.78	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.41	0.8	47.49	9.27	0.49	N	0.96	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11618	11618	G	A	MI.18126	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	859	287	A	T	Gca/Aca	-4.35	0	0	probably_damaging	1	deleterious	0	neutral	2.92	deleterious	-7.72	deleterious	-3.78	high_impact	4.08	0.6	damaging	0.09	damaging	4.28	24.00	deleterious	0.02	0.35	0.68	disease	0.82	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.91	high_impact	0.72	0.85	47.49	9.27	0.34	N	0.82	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11618	11618	G	T	MI.18127	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	859	287	A	S	Gca/Tca	-4.35	0	0	probably_damaging	1	deleterious	0	neutral	2.93	deleterious	-5.78	deleterious	-2.84	high_impact	4.29	0.59	damaging	0.1	damaging	3.76	23.30	deleterious	0.04	0.35	0.77	disease	0.83	disease	0.67	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.12	high_impact	0.43	0.8	47.49	9.27	0.38	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11619	11619	C	G	MI.18128	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	860	287	A	G	gCa/gGa	9.24	1	0	probably_damaging	1	deleterious	0	neutral	2.99	deleterious	-6.06	deleterious	-3.78	high_impact	3.94	0.51	damaging	0.14	damaging	4.01	23.60	deleterious	0.03	0.35	0.44	neutral	0.81	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.54	low_impact	-1.48	low_impact	2.77	high_impact	0.54	0.8	47.49	9.27	0.57	P	0.79	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11619	11619	C	A	MI.18129	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	860	287	A	E	gCa/gAa	9.24	1	0	probably_damaging	1	deleterious	0	neutral	2.89	deleterious	-10.46	deleterious	-4.73	high_impact	4.63	0.57	damaging	0.09	damaging	4.49	24.30	deleterious	0.02	0.35	0.87	disease	0.88	disease	0.76	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.33	0.8	47.49	9.27	0.57	P	0.99	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8540	8540	T	A	MI.1813	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	175	59	C	S	Tgt/Agt	-1.95	0	0	benign	0	neutral	0.77	neutral	1.95	neutral	-0.98	neutral	-1.28	low_impact	1.38	1	neutral	0.61	neutral	3.94	23.50	deleterious	0.60038707	0.85	0.44	neutral	0.27	neutral	0.59	disease	0.16	neutral	7	0.22	neutral	0.89	deleterious	-6	neutral	0.20	neutral	2.09	high_impact	0.59	medium_impact	0.09	medium_impact	0.54	0.85	19.12	7.68	0.28	N	0.29	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11619	11619	C	T	MI.18130	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	860	287	A	V	gCa/gTa	9.24	1	0	probably_damaging	1	deleterious	0	neutral	2.95	deleterious	-8.92	deleterious	-3.78	high_impact	4.63	0.49	damaging	0.08	damaging	4.49	24.30	deleterious	0.02	0.35	0.48	neutral	0.85	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.70	0.85	47.49	9.27	0.53	P	0.72	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11621	11621	T	A	MI.18131	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	862	288	Y	N	Tac/Aac	-2.5	0	0	probably_damaging	1	deleterious	0	neutral	4.14	deleterious	-8.25	deleterious	-8.49	high_impact	4.21	0.44	damaging	0.05	damaging	4.11	23.70	deleterious	0.03	0.35	0.81	disease	0.84	disease	0.79	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.04	high_impact	0.13	0.8	47.49	9.34	0.45	N	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11621	11621	T	G	MI.18132	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	862	288	Y	D	Tac/Gac	-2.5	0	0	probably_damaging	1	deleterious	0	neutral	4.14	deleterious	-10.67	deleterious	-9.42	high_impact	3.87	0.44	damaging	0.06	damaging	4.07	23.70	deleterious	0.02	0.35	0.88	disease	0.9	disease	0.85	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.7	high_impact	0.13	0.8	47.49	9.34	0.46	N	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11621	11621	T	C	MI.18133	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	862	288	Y	H	Tac/Cac	-2.5	0	0	probably_damaging	1	deleterious	0	neutral	4.14	deleterious	-7.77	deleterious	-4.72	high_impact	4.56	0.46	damaging	0.05	damaging	3.65	23.20	deleterious	0.06	0.35	0.83	disease	0.81	disease	0.85	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.39	high_impact	0.19	0.8	47.49	9.34	0.52	P	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11622	11622	A	C	MI.18134	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	863	288	Y	S	tAc/tCc	7.4	1	0	probably_damaging	1	deleterious	0.01	neutral	4.17	deleterious	-8.59	deleterious	-8.49	high_impact	3.87	0.44	damaging	0.08	damaging	3.65	23.20	deleterious	0.03	0.35	0.67	disease	0.86	disease	0.77	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-0.92	medium_impact	2.7	high_impact	0.12	0.8	47.49	9.34	0.66	P	0.95	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11622	11622	A	G	MI.18135	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	863	288	Y	C	tAc/tGc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.17	deleterious	-8.85	deleterious	-8.5	high_impact	3.75	0.43	damaging	0.05	damaging	3.45	23.00	deleterious	0.04	0.35	0.62	disease	0.86	disease	0.82	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.58	high_impact	0.16	0.8	47.49	9.34	0.63	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11622	11622	A	T	MI.18136	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	863	288	Y	F	tAc/tTc	7.4	1	0	probably_damaging	1	neutral	0.09	neutral	4.27	deleterious	-4.22	deleterious	-3.78	medium_impact	2.85	0.47	damaging	0.07	damaging	3.31	22.90	deleterious	0.14	0.4	0.35	neutral	0.82	disease	0.73	disease	0.7	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.36	medium_impact	1.69	medium_impact	0.39	0.8	47.49	9.34	0.6	P	0.79	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11624	11624	T	G	MI.18137	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	865	289	S	A	Tct/Gct	-0.43	0.08	0	possibly_damaging	0.64	deleterious	0	neutral	2.51	deleterious	-6.22	deleterious	-2.84	medium_impact	3.46	0.48	damaging	0.63	neutral	3.72	23.30	deleterious	0.09	0.4	0.55	disease	0.56	disease	0.75	disease	0.72	disease	4	1	deleterious	0.18	neutral	4	deleterious	0.75	deleterious	-0.95	medium_impact	-1.48	low_impact	2.3	high_impact	0.39	0.8	47.28	9.28	0.52	P	0.36	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11624	11624	T	A	MI.18138	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	865	289	S	T	Tct/Act	-0.43	0.08	0	possibly_damaging	0.85	deleterious	0	neutral	2.47	deleterious	-7.09	deleterious	-2.84	medium_impact	3.23	0.51	damaging	0.57	neutral	4.05	23.70	deleterious	0.08	0.35	0.67	disease	0.66	disease	0.76	disease	0.71	disease	4	1	deleterious	0.08	neutral	4	deleterious	0.81	deleterious	-1.43	low_impact	-1.48	low_impact	2.07	high_impact	0.49	0.8	47.28	9.28	0.5	N	0.57	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11624	11624	T	C	MI.18139	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	865	289	S	P	Tct/Cct	-0.43	0.08	0	benign	0.12	deleterious	0	neutral	2.45	deleterious	-8.54	deleterious	-4.73	high_impact	4.26	0.45	damaging	0.74	neutral	4.09	23.70	deleterious	0.03	0.35	0.88	disease	0.81	disease	0.85	disease	0.75	disease	5	1	deleterious	0.44	neutral	2	deleterious	0.87	deleterious	0.1	medium_impact	-1.48	low_impact	3.09	high_impact	0.31	0.8	47.28	9.28	0.53	P	0.05	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8540	8540	T	G	MI.1814	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	175	59	C	G	Tgt/Ggt	-1.95	0	0	benign	0	neutral	0.59	neutral	1.93	neutral	-1.88	neutral	-2.28	low_impact	1.38	1	neutral	0.54	neutral	4.03	23.60	deleterious	0.50207441	0.85	0.56	disease	0.43	neutral	0.61	disease	0.28	neutral	4	0.4	neutral	0.8	deleterious	-6	neutral	0.24	neutral	2.09	high_impact	0.38	medium_impact	0.09	medium_impact	0.35	0.85	19.12	7.68	0.3	N	0.36	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11625	11625	C	A	MI.18140	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	866	289	S	Y	tCt/tAt	4.63	1	0	probably_damaging	0.98	deleterious	0	neutral	2.44	deleterious	-10.34	deleterious	-5.68	high_impact	4.62	0.47	damaging	0.5	neutral	4.11	23.70	deleterious	0.03	0.35	0.83	disease	0.85	disease	0.77	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.31	low_impact	-1.48	low_impact	3.45	high_impact	0.23	0.8	47.28	9.28	0.61	P	0.95	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11625	11625	C	G	MI.18141	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	866	289	S	C	tCt/tGt	4.63	1	0	probably_damaging	0.98	deleterious	0	neutral	2.49	deleterious	-6.66	deleterious	-4.74	high_impact	4.62	0.48	damaging	0.51	neutral	3.67	23.20	deleterious	0.04	0.35	0.76	disease	0.77	disease	0.74	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.31	low_impact	-1.48	low_impact	3.45	high_impact	0.27	0.8	47.28	9.28	0.61	P	0.57	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11625	11625	C	T	MI.18142	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	866	289	S	F	tCt/tTt	4.63	1	0	probably_damaging	0.98	deleterious	0	neutral	2.44	deleterious	-9.94	deleterious	-5.68	high_impact	4.26	0.48	damaging	0.57	neutral	4.22	23.90	deleterious	0.03	0.35	0.77	disease	0.88	disease	0.76	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.31	low_impact	-1.48	low_impact	3.09	high_impact	0.17	0.8	47.28	9.28	0.57	P	0.94	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11627	11627	T	G	MI.18143	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	868	290	S	A	Tca/Gca	-8.72	0	0	possibly_damaging	0.64	deleterious	0	neutral	3.97	deleterious	-3.71	deleterious	-2.84	high_impact	4.29	0.48	damaging	0.52	neutral	3.75	23.30	deleterious	0.07	0.35	0.51	disease	0.56	disease	0.74	disease	0.69	disease	4	1	deleterious	0.18	neutral	5	deleterious	0.74	deleterious	-0.95	medium_impact	-1.48	low_impact	3.12	high_impact	0.38	0.8	47.49	9.35	0.55	P	0.51	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11627	11627	T	A	MI.18144	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	868	290	S	T	Tca/Aca	-8.72	0	0	possibly_damaging	0.85	deleterious	0	neutral	4.51	neutral	-0.37	deleterious	-2.84	high_impact	4.29	0.55	damaging	0.45	neutral	3.87	23.50	deleterious	0.11	0.4	0.71	disease	0.66	disease	0.73	disease	0.69	disease	4	1	deleterious	0.08	neutral	5	deleterious	0.81	deleterious	-1.43	low_impact	-1.48	low_impact	3.12	high_impact	0.46	0.8	47.49	9.35	0.48	N	0.73	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11627	11627	T	C	MI.18145	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	868	290	S	P	Tca/Cca	-8.72	0	0	benign	0.12	deleterious	0	neutral	3.91	deleterious	-6	deleterious	-4.72	high_impact	4.29	0.45	damaging	0.48	neutral	4.05	23.70	deleterious	0.03	0.35	0.82	disease	0.81	disease	0.8	disease	0.71	disease	4	1	deleterious	0.44	neutral	2	deleterious	0.87	deleterious	0.1	medium_impact	-1.48	low_impact	3.12	high_impact	0.29	0.8	47.49	9.35	0.48	N	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11628	11628	C	G	MI.18146	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	869	290	S	W	tCa/tGa	5.78	1	0	probably_damaging	0.99	deleterious	0	neutral	3.9	deleterious	-9.39	deleterious	-6.62	high_impact	4.63	0.55	damaging	0.51	neutral	4.42	24.20	deleterious	0.03	0.35	0.95	disease	0.88	disease	0.77	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.59	low_impact	-1.48	low_impact	3.45	high_impact	0.13	0.8	47.49	9.35	0.58	P	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11628	11628	C	T	MI.18147	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	869	290	S	L	tCa/tTa	5.78	1	0	probably_damaging	0.91	deleterious	0	neutral	3.91	deleterious	-6.25	deleterious	-5.67	high_impact	4.63	0.47	damaging	0.44	neutral	4.67	24.50	deleterious	0.02	0.35	0.43	neutral	0.86	disease	0.72	disease	0.71	disease	4	1	deleterious	0.05	neutral	6	deleterious	0.77	deleterious	-1.66	low_impact	-1.48	low_impact	3.45	high_impact	0.39	0.8	47.49	9.35	0.62	P	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11630	11630	A	G	MI.18148	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	871	291	I	V	Atc/Gtc	-11.94	0	0	benign	0	neutral	1	neutral	4.34	neutral	-0.26	neutral	0.84	neutral_impact	-1.59	0.79	neutral	0.94	neutral	-1.51	0.00	neutral	0.45	0.55	0.37	neutral	0.09	neutral	0.35	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	1.88	high_impact	-2.7	low_impact	0.38	0.8	44.88	8.84	0.28	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11630	11630	A	C	MI.18149	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	871	291	I	L	Atc/Ctc	-11.94	0	0	benign	0.05	neutral	0.07	neutral	4.27	neutral	-2.32	neutral	-1.89	medium_impact	1.98	0.71	neutral	0.54	neutral	1.97	16.02	deleterious	0.17	0.45	0.35	neutral	0.59	disease	0.64	disease	0.69	disease	4	0.93	neutral	0.51	deleterious	-3	neutral	0.21	neutral	0.48	medium_impact	-0.43	medium_impact	0.83	medium_impact	0.49	0.8	44.88	8.84	0.46	N	0.14	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8540	8540	T	C	MI.1815	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	175	59	C	R	Tgt/Cgt	-1.95	0	0	benign	0	neutral	0.39	neutral	1.94	neutral	-1.78	neutral	-1.56	low_impact	1.38	0.99	neutral	0.54	neutral	3.72	23.30	deleterious	0.55776640	0.85	0.58	disease	0.51	disease	0.67	disease	0.63	disease	3	0.6	neutral	0.7	deleterious	-6	neutral	0.26	neutral	2.09	high_impact	0.18	medium_impact	0.09	medium_impact	0.26	0.85	19.12	7.68	0.39	N	0.33	disease_causing	1	0.08	rs878852987	Uncertain_significance	not_provided	236915	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11630	11630	A	T	MI.18150	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	871	291	I	F	Atc/Ttc	-11.94	0	0	possibly_damaging	0.55	deleterious	0	neutral	4.07	deleterious	-4.74	deleterious	-3.79	medium_impact	2.33	0.7	neutral	0.54	neutral	2.19	17.42	deleterious	0.05	0.35	0.39	neutral	0.81	disease	0.7	disease	0.75	disease	5	1	deleterious	0.23	neutral	4	deleterious	0.41	neutral	-0.8	medium_impact	-1.48	low_impact	1.18	medium_impact	0.56	0.8	44.88	8.84	0.4	N	0.31	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11631	11631	T	A	MI.18151	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	872	291	I	N	aTc/aAc	1.87	0.99	0	possibly_damaging	0.8	deleterious	0	neutral	4.05	deleterious	-6.05	deleterious	-5.73	medium_impact	2.88	0.68	neutral	0.54	neutral	4.31	24.00	deleterious	0.04	0.35	0.78	disease	0.85	disease	0.69	disease	0.75	disease	5	1	deleterious	0.1	neutral	4	deleterious	0.74	deleterious	-1.28	low_impact	-1.48	low_impact	1.72	medium_impact	0.24	0.8	44.88	8.84	0.47	N	0.47	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11631	11631	T	C	MI.18152	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	872	291	I	T	aTc/aCc	1.87	0.99	0	benign	0.18	deleterious	0	neutral	4.08	deleterious	-3.79	deleterious	-2.94	medium_impact	2.88	0.72	neutral	0.5	neutral	1.66	14.20	neutral	0.04	0.35	0.4	neutral	0.53	disease	0.66	disease	0.7	disease	4	1	deleterious	0.41	neutral	1	deleterious	0.28	neutral	-0.1	medium_impact	-1.48	low_impact	1.72	medium_impact	0.19	0.8	44.88	8.84	0.47	N	0.18	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11631	11631	T	G	MI.18153	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	872	291	I	S	aTc/aGc	1.87	0.99	0	benign	0.41	deleterious	0	neutral	4.08	deleterious	-4.34	deleterious	-4.79	medium_impact	2.88	0.7	neutral	0.55	neutral	2.59	20.10	deleterious	0.03	0.35	0.65	disease	0.8	disease	0.66	disease	0.75	disease	5	1	deleterious	0.3	neutral	1	deleterious	0.46	deleterious	-0.57	medium_impact	-1.48	low_impact	1.72	medium_impact	0.15	0.8	44.88	8.84	0.46	N	0.32	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11632	11632	C	G	MI.18154	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	873	291	I	M	atC/atG	7.4	1	0	possibly_damaging	0.55	deleterious	0	neutral	4.14	deleterious	-3.19	neutral	-1.94	medium_impact	2.52	0.74	neutral	0.48	neutral	1.84	15.23	deleterious	0.11	0.4	0.56	disease	0.63	disease	0.68	disease	0.71	disease	4	1	deleterious	0.23	neutral	4	deleterious	0.54	deleterious	-0.8	medium_impact	-1.48	low_impact	1.37	medium_impact	0.61	0.8	44.88	8.84	0.61	P	0.11	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11632	11632	C	A	MI.18155	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	873	291	I	M	atC/atA	7.4	1	0	possibly_damaging	0.55	deleterious	0	neutral	4.14	deleterious	-3.19	neutral	-1.94	medium_impact	2.52	0.74	neutral	0.48	neutral	2.24	17.78	deleterious	0.11	0.4	0.56	disease	0.63	disease	0.68	disease	0.71	disease	4	1	deleterious	0.23	neutral	4	deleterious	0.54	deleterious	-0.8	medium_impact	-1.48	low_impact	1.37	medium_impact	0.61	0.8	44.88	8.84	0.61	P	0.11	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11633	11633	A	C	MI.18156	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	874	292	S	R	Agc/Cgc	-20	0	0	probably_damaging	1	deleterious	0.01	neutral	4.34	deleterious	-4.3	deleterious	-4.58	high_impact	4.17	0.72	neutral	0.13	damaging	3.86	23.50	deleterious	0.03	0.35	0.51	disease	0.89	disease	0.77	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-0.92	medium_impact	3	high_impact	0.38	0.8	46.62	9.31	0.39	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11633	11633	A	T	MI.18157	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	874	292	S	C	Agc/Tgc	-20	0	0	probably_damaging	1	neutral	0.11	neutral	4.33	deleterious	-6.39	deleterious	-4.65	medium_impact	2.79	0.7	neutral	0.1	damaging	3.43	23.00	deleterious	0.05	0.35	0.91	disease	0.82	disease	0.66	disease	0.71	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.31	medium_impact	1.63	medium_impact	0.32	0.8	46.62	9.31	0.28	N	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11633	11633	A	G	MI.18158	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	874	292	S	G	Agc/Ggc	-20	0	0	probably_damaging	1	neutral	0.36	neutral	4.42	deleterious	-3.15	deleterious	-3.37	low_impact	1.72	0.73	neutral	0.31	neutral	2.55	19.77	deleterious	0.12	0.4	0.5	neutral	0.58	disease	0.51	disease	0.33	neutral	3	1	deleterious	0.18	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.06	medium_impact	0.58	medium_impact	0.52	0.8	46.62	9.31	0.3	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11634	11634	G	A	MI.18159	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	875	292	S	N	aGc/aAc	4.63	1	0	probably_damaging	1	deleterious	0.03	neutral	4.36	deleterious	-3.92	deleterious	-2.71	medium_impact	3.07	0.73	neutral	0.14	damaging	3.65	23.20	deleterious	0.21	0.45	0.5	neutral	0.76	disease	0.68	disease	0.67	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.64	medium_impact	1.91	medium_impact	0.29	0.8	46.62	9.31	0.52	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8541	8541	G	C	MI.1816	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	176	59	C	S	tGt/tCt	7.53	1	0	benign	0	neutral	0.77	neutral	1.95	neutral	-0.98	neutral	-1.28	low_impact	1.38	1	neutral	0.61	neutral	0.49	7.39	deleterious	0.60038707	0.85	0.44	neutral	0.27	neutral	0.59	disease	0.16	neutral	7	0.22	neutral	0.89	deleterious	-6	neutral	0.20	neutral	2.09	high_impact	0.59	medium_impact	0.09	medium_impact	0.54	0.85	19.12	7.68	0.51	N	0.29	polymorphism	0.72	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11634	11634	G	C	MI.18160	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	875	292	S	T	aGc/aCc	4.63	1	0	probably_damaging	1	neutral	0.19	neutral	4.4	deleterious	-3.99	deleterious	-2.79	medium_impact	3.07	0.7	neutral	0.13	damaging	3.48	23.10	deleterious	0.14	0.4	0.48	neutral	0.68	disease	0.67	disease	0.65	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.15	medium_impact	1.91	medium_impact	0.57	0.8	46.62	9.31	0.55	P	0.73	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11634	11634	G	T	MI.18161	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	875	292	S	I	aGc/aTc	4.63	1	0	probably_damaging	1	deleterious	0.03	neutral	4.35	deleterious	-4.81	deleterious	-5.59	medium_impact	2.82	0.71	neutral	0.14	damaging	4.18	23.80	deleterious	0.03	0.35	0.76	disease	0.92	disease	0.69	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.86	deleterious	-3.54	low_impact	-0.64	medium_impact	1.66	medium_impact	0.28	0.8	46.62	9.31	0.44	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11636	11636	C	A	MI.18162	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	877	293	H	N	Cac/Aac	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	4.35	neutral	-1.59	deleterious	-6.61	high_impact	4.64	0.51	damaging	0.1	damaging	3.93	23.50	deleterious	0.16	0.45	0.59	disease	0.84	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.23	0.8	47.28	9.28	0.56	P	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11636	11636	C	T	MI.18163	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	877	293	H	Y	Cac/Tac	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	4.19	deleterious	-5.66	deleterious	-5.66	high_impact	4.64	0.57	damaging	0.09	damaging	3.79	23.40	deleterious	0.06	0.35	0.41	neutral	0.89	disease	0.79	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.24	0.8	47.28	9.28	0.53	P	0.99	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11636	11636	C	G	MI.18164	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	877	293	H	D	Cac/Gac	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	4.25	neutral	-2.99	deleterious	-8.5	high_impact	4.64	0.61	neutral	0.1	damaging	3.89	23.50	deleterious	0.05	0.35	0.68	disease	0.9	disease	0.84	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.21	0.8	47.28	9.28	0.61	P	0.97	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11637	11637	A	C	MI.18165	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	878	293	H	P	cAc/cCc	5.55	1	0	probably_damaging	1	deleterious	0	neutral	4.2	deleterious	-4.99	deleterious	-9.44	high_impact	4.64	0.56	damaging	0.1	damaging	3.28	22.80	deleterious	0.03	0.35	0.73	disease	0.9	disease	0.86	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.16	0.8	47.28	9.28	0.68	P	0.95	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11637	11637	A	G	MI.18166	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	878	293	H	R	cAc/cGc	5.55	1	0	probably_damaging	1	deleterious	0	neutral	4.23	deleterious	-3.49	deleterious	-7.55	high_impact	4.64	0.55	damaging	0.09	damaging	3.04	22.40	deleterious	0.06	0.35	0.46	neutral	0.89	disease	0.82	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.28	0.8	47.28	9.28	0.71	P	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11637	11637	A	T	MI.18167	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	878	293	H	L	cAc/cTc	5.55	1	0	probably_damaging	1	deleterious	0	neutral	4.2	deleterious	-4.65	deleterious	-10.38	high_impact	4.64	0.53	damaging	0.09	damaging	3.96	23.60	deleterious	0.03	0.35	0.76	disease	0.93	disease	0.78	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.23	0.8	47.28	9.28	0.67	P	0.96	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11638	11638	C	G	MI.18168	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	879	293	H	Q	caC/caG	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.54	neutral	-0.44	deleterious	-7.55	high_impact	4.29	0.57	damaging	0.09	damaging	3.61	23.20	deleterious	0.11	0.4	0.44	neutral	0.85	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.12	high_impact	0.25	0.8	47.28	9.28	0.66	P	0.93	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11638	11638	C	A	MI.18169	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	879	293	H	Q	caC/caA	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.54	neutral	-0.44	deleterious	-7.55	high_impact	4.29	0.57	damaging	0.09	damaging	4.02	23.60	deleterious	0.11	0.4	0.44	neutral	0.85	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.12	high_impact	0.25	0.8	47.28	9.28	0.66	P	0.93	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8541	8541	G	A	MI.1817	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	176	59	C	Y	tGt/tAt	7.53	1	0	benign	0	neutral	1	neutral	2.81	neutral	2.59	neutral	5.76	neutral_impact	-2.05	0.99	neutral	0.86	neutral	0.49	7.38	deleterious	0.56663707	0.85	0.12	neutral	0.1	neutral	0.4	neutral	0.04	neutral	9	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	1.98	high_impact	-2.85	low_impact	0.49	0.85	19.12	7.68	0.53	N	0.16	polymorphism	0.55	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11639	11639	A	C	MI.18170	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	880	294	M	L	Ata/Cta	-3.19	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.63	neutral	-0.06	deleterious	-2.83	high_impact	3.65	0.69	neutral	0.1	damaging	3.09	22.50	deleterious	0.18	0.45	0.63	disease	0.87	disease	0.72	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.67	deleterious	-2.31	low_impact	-0.92	medium_impact	2.49	high_impact	0.38	0.8	47.28	9.16	0.32	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11639	11639	A	T	MI.18171	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	880	294	M	L	Ata/Tta	-3.19	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.63	neutral	-0.06	deleterious	-2.83	high_impact	3.65	0.69	neutral	0.1	damaging	3.19	22.70	deleterious	0.18	0.45	0.63	disease	0.87	disease	0.72	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.67	deleterious	-2.31	low_impact	-0.92	medium_impact	2.49	high_impact	0.38	0.8	47.28	9.16	0.32	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11639	11639	A	G	MI.18172	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	880	294	M	V	Ata/Gta	-3.19	0	0	probably_damaging	0.99	deleterious	0	neutral	4.43	neutral	-1.33	deleterious	-3.77	high_impact	3.65	0.65	neutral	0.13	damaging	2.56	19.83	deleterious	0.11	0.4	0.69	disease	0.88	disease	0.72	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.72	deleterious	-2.59	low_impact	-1.48	low_impact	2.49	high_impact	0.38	0.8	47.28	9.16	0.32	N	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11640	11640	T	A	MI.18173	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	881	294	M	K	aTa/aAa	6.7	1	0	probably_damaging	1	deleterious	0	neutral	4.29	deleterious	-4.36	deleterious	-5.65	high_impact	4.28	0.68	neutral	0.12	damaging	4.04	23.70	deleterious	0.03	0.35	0.59	disease	0.92	disease	0.8	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.11	high_impact	0.20	0.8	47.28	9.16	0.65	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11640	11640	T	C	MI.18174	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	881	294	M	T	aTa/aCa	6.7	1	0	probably_damaging	1	deleterious	0	neutral	4.32	deleterious	-3.09	deleterious	-5.65	high_impact	4.62	0.79	neutral	0.14	damaging	3.02	22.30	deleterious	0.04	0.35	0.41	neutral	0.87	disease	0.74	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.19	0.8	47.28	9.16	0.59	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11641	11641	A	C	MI.18175	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	882	294	M	I	atA/atC	7.4	1	0	probably_damaging	0.99	neutral	0.05	neutral	4.5	neutral	-0.79	deleterious	-3.78	high_impact	3.82	0.69	neutral	0.14	damaging	3.45	23.00	deleterious	0.11	0.4	0.77	disease	0.9	disease	0.74	disease	0.73	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	-0.52	medium_impact	2.65	high_impact	0.34	0.8	47.28	9.16	0.66	P	0.95	disease_causing	1	0.18	rs2853494	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11641	11641	A	T	MI.18176	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	882	294	M	I	atA/atT	7.4	1	0	probably_damaging	0.99	neutral	0.05	neutral	4.5	neutral	-0.79	deleterious	-3.78	high_impact	3.82	0.69	neutral	0.14	damaging	3.56	23.10	deleterious	0.11	0.4	0.77	disease	0.9	disease	0.74	disease	0.73	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	-0.52	medium_impact	2.65	high_impact	0.34	0.8	47.28	9.16	0.66	P	0.95	disease_causing	1	0.18	rs2853494	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11642	11642	G	A	MI.18177	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	883	295	A	T	Gcc/Acc	0.03	0.78	0	probably_damaging	0.91	deleterious	0.03	neutral	4.58	neutral	-1.59	deleterious	-3.02	medium_impact	2.25	0.65	neutral	0.1	damaging	4.31	24.00	deleterious	0.07	0.35	0.51	disease	0.73	disease	0.64	disease	0.7	disease	4	0.99	deleterious	0.06	neutral	5	deleterious	0.82	deleterious	-1.66	low_impact	-0.64	medium_impact	1.1	medium_impact	0.73	0.85	14.81	17.1	0.32	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11642	11642	G	T	MI.18178	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	883	295	A	S	Gcc/Tcc	0.03	0.78	0	benign	0.33	neutral	0.47	neutral	4.81	neutral	0.29	neutral	-1.69	low_impact	0.92	0.73	neutral	0.22	damaging	3.74	23.30	deleterious	0.15	0.4	0.39	neutral	0.72	disease	0.41	neutral	0.37	neutral	3	0.44	neutral	0.57	deleterious	-6	neutral	0.80	deleterious	-0.43	medium_impact	0.17	medium_impact	-0.22	medium_impact	0.43	0.8	14.81	17.1	0.26	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11642	11642	G	C	MI.18179	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	883	295	A	P	Gcc/Ccc	0.03	0.78	0	probably_damaging	0.98	deleterious	0.01	neutral	4.56	neutral	-2.9	deleterious	-3.6	medium_impact	3.35	0.52	damaging	0.06	damaging	3.87	23.50	deleterious	0.03	0.35	0.58	disease	0.94	disease	0.76	disease	0.83	disease	7	1	deleterious	0.02	neutral	5	deleterious	0.90	deleterious	-2.31	low_impact	-0.92	medium_impact	2.19	high_impact	0.29	0.8	14.81	17.1	0.37	N	0.95	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8541	8541	G	T	MI.1818	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	176	59	C	F	tGt/tTt	7.53	1	0	benign	0	neutral	0.68	neutral	2.03	neutral	-0.13	neutral	2.56	low_impact	1.38	1	neutral	0.7	neutral	0.37	6.35	deleterious	0.51545309	0.85	0.27	neutral	0.41	neutral	0.51	disease	0.17	neutral	7	0.32	neutral	0.84	deleterious	-6	neutral	0.18	neutral	2.09	high_impact	0.48	medium_impact	0.09	medium_impact	0.42	0.85	19.12	7.68	0.51	N	0.16	disease_causing	0.68	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11643	11643	C	A	MI.18180	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	884	295	A	D	gCc/gAc	6.01	1	0	probably_damaging	0.96	deleterious	0	neutral	4.57	deleterious	-4.37	deleterious	-3.79	medium_impact	3.35	0.57	damaging	0.07	damaging	4.70	24.60	deleterious	0.02	0.35	0.37	neutral	0.94	disease	0.75	disease	0.82	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.86	deleterious	-2.01	low_impact	-1.48	low_impact	2.19	high_impact	0.20	0.8	14.81	17.1	0.52	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11643	11643	C	G	MI.18181	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	884	295	A	G	gCc/gGc	6.01	1	0	possibly_damaging	0.86	neutral	1	neutral	5.81	neutral	5.97	neutral	-0.03	neutral_impact	-0.56	0.64	neutral	0.53	neutral	1.32	12.39	neutral	0.13	0.4	0.52	disease	0.18	neutral	0.41	neutral	0.2	neutral	6	0.85	neutral	0.57	deleterious	-3	neutral	0.71	deleterious	-1.46	low_impact	1.88	high_impact	-1.68	low_impact	0.52	0.8	14.81	17.1	0.57	P	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11643	11643	C	T	MI.18182	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	884	295	A	V	gCc/gTc	6.01	1	0	probably_damaging	0.94	deleterious	0	neutral	4.56	neutral	-2.98	deleterious	-3.41	medium_impact	3.35	0.63	neutral	0.09	damaging	4.52	24.30	deleterious	0.04	0.35	0.68	disease	0.87	disease	0.65	disease	0.77	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.87	deleterious	-1.84	low_impact	-1.48	low_impact	2.19	high_impact	0.71	0.85	14.81	17.1	0.58	P	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11645	11645	C	A	MI.18183	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	886	296	L	I	Ctc/Atc	-11.71	0	0	probably_damaging	1	neutral	0.34	neutral	4.54	neutral	-0.98	neutral	-1.89	medium_impact	2.17	0.7	neutral	0.13	damaging	4.17	23.80	deleterious	0.25	0.45	0.62	disease	0.64	disease	0.53	disease	0.37	neutral	3	1	deleterious	0.17	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.04	medium_impact	1.02	medium_impact	0.40	0.8	47.28	9.18	0.29	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11645	11645	C	T	MI.18184	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	886	296	L	F	Ctc/Ttc	-11.71	0	0	probably_damaging	1	neutral	0.19	neutral	4.72	neutral	0.46	deleterious	-3.76	medium_impact	2.12	0.71	neutral	0.13	damaging	4.03	23.70	deleterious	0.23	0.45	0.89	disease	0.78	disease	0.63	disease	0.69	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.15	medium_impact	0.97	medium_impact	0.41	0.8	47.28	9.18	0.26	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11645	11645	C	G	MI.18185	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	886	296	L	V	Ctc/Gtc	-11.71	0	0	probably_damaging	1	neutral	0.06	neutral	4.53	neutral	-1.04	deleterious	-2.84	medium_impact	2.52	0.65	neutral	0.11	damaging	3.52	23.10	deleterious	0.24	0.45	0.7	disease	0.68	disease	0.63	disease	0.65	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.47	medium_impact	1.37	medium_impact	0.50	0.8	47.28	9.18	0.28	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11646	11646	T	A	MI.18186	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	887	296	L	H	cTc/cAc	0.72	0.17	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-3.92	deleterious	-6.62	high_impact	3.94	0.65	neutral	0.1	damaging	4.22	23.90	deleterious	0.04	0.35	0.7	disease	0.82	disease	0.72	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.77	high_impact	0.24	0.8	47.28	9.18	0.36	N	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11646	11646	T	C	MI.18187	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	887	296	L	P	cTc/cCc	0.72	0.17	0	probably_damaging	1	deleterious	0.01	neutral	4.43	deleterious	-4.51	deleterious	-6.62	high_impact	3.94	0.6	neutral	0.1	damaging	4.00	23.60	deleterious	0.03	0.35	0.36	neutral	0.84	disease	0.74	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-0.92	medium_impact	2.77	high_impact	0.45	0.8	47.28	9.18	0.39	N	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11646	11646	T	G	MI.18188	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	887	296	L	R	cTc/cGc	0.72	0.17	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-3.95	deleterious	-5.67	high_impact	4.29	0.6	damaging	0.09	damaging	4.29	24.00	deleterious	0.02	0.35	0.47	neutral	0.89	disease	0.74	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.12	high_impact	0.12	0.8	47.28	9.18	0.45	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11648	11648	G	C	MI.18189	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	889	297	V	L	Gta/Cta	-10.79	0	0	probably_damaging	1	neutral	0.07	neutral	4.58	neutral	-0.71	deleterious	-2.83	medium_impact	2.59	0.65	neutral	0.09	damaging	3.60	23.20	deleterious	0.15	0.4	0.53	disease	0.75	disease	0.62	disease	0.57	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.43	medium_impact	1.44	medium_impact	0.32	0.8	47.06	9.36	0.28	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8542	8542	T	A	MI.1819	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	177	59	C	W	tgT/tgA	0.13	0.97	0	benign	0.01	neutral	0.18	neutral	1.94	neutral	-2.56	neutral	1.76	low_impact	1.38	0.99	neutral	0.51	neutral	4.30	24.00	deleterious	0.46155204	0.85	0.62	disease	0.49	neutral	0.69	disease	0.62	disease	2	0.82	neutral	0.59	deleterious	-6	neutral	0.27	neutral	1.14	medium_impact	-0.08	medium_impact	0.09	medium_impact	0.32	0.85	19.12	7.68	0.54	N	0.12	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11648	11648	G	T	MI.18190	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	889	297	V	L	Gta/Tta	-10.79	0	0	probably_damaging	1	neutral	0.07	neutral	4.58	neutral	-0.71	deleterious	-2.83	medium_impact	2.59	0.65	neutral	0.09	damaging	3.76	23.40	deleterious	0.15	0.4	0.53	disease	0.75	disease	0.62	disease	0.57	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.43	medium_impact	1.44	medium_impact	0.32	0.8	47.06	9.36	0.28	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11648	11648	G	A	MI.18191	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	889	297	V	M	Gta/Ata	-10.79	0	0	probably_damaging	1	neutral	0.09	neutral	4.45	neutral	0.08	deleterious	-2.84	medium_impact	2.29	0.73	neutral	0.14	damaging	3.80	23.40	deleterious	0.14	0.4	0.79	disease	0.73	disease	0.59	disease	0.52	disease	0	1	deleterious	0.05	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.36	medium_impact	1.14	medium_impact	0.54	0.8	47.06	9.36	0.26	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11649	11649	T	G	MI.18192	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	890	297	V	G	gTa/gGa	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.38	deleterious	-4.19	deleterious	-6.62	medium_impact	3.35	0.63	neutral	0.11	damaging	3.89	23.50	deleterious	0.02	0.35	0.61	disease	0.83	disease	0.66	disease	0.69	disease	4	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	2.19	high_impact	0.33	0.8	47.06	9.36	0.54	P	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11649	11649	T	A	MI.18193	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	890	297	V	E	gTa/gAa	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.38	deleterious	-4.32	deleterious	-5.68	high_impact	4.38	0.68	neutral	0.11	damaging	4.73	24.60	deleterious	0.01	0.35	0.37	neutral	0.89	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.21	high_impact	0.15	0.8	47.06	9.36	0.62	P	0.97	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11649	11649	T	C	MI.18194	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	890	297	V	A	gTa/gCa	7.4	1	0	probably_damaging	1	neutral	0.05	neutral	4.46	neutral	-1.94	deleterious	-3.78	medium_impact	2.7	0.65	neutral	0.13	damaging	3.64	23.20	deleterious	0.05	0.35	0.39	neutral	0.58	disease	0.63	disease	0.55	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.52	medium_impact	1.55	medium_impact	0.10	0.8	47.06	9.36	0.64	P	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11651	11651	G	A	MI.18195	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	892	298	V	M	Gta/Ata	-3.42	0	0	possibly_damaging	0.66	neutral	0.16	neutral	4.81	neutral	-0.89	neutral	-1.79	low_impact	0.84	0.77	neutral	0.57	neutral	2.20	17.50	deleterious	0.25	0.45	0.56	disease	0.47	neutral	0.56	disease	0.65	disease	3	0.86	neutral	0.25	neutral	-3	neutral	0.54	deleterious	-0.99	medium_impact	-0.2	medium_impact	-0.3	medium_impact	0.83	0.85	28.54	8.66	0.33	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11651	11651	G	C	MI.18196	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	892	298	V	L	Gta/Cta	-3.42	0	0	benign	0.05	neutral	0.78	neutral	4.86	neutral	0.81	neutral	-1.14	neutral_impact	0.06	0.73	neutral	0.57	neutral	1.68	14.29	neutral	0.2	0.45	0.4	neutral	0.41	neutral	0.34	neutral	0.46	neutral	1	0.14	neutral	0.87	deleterious	-6	neutral	0.18	neutral	0.48	medium_impact	0.51	medium_impact	-1.07	low_impact	0.50	0.8	28.54	8.66	0.28	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11651	11651	G	T	MI.18197	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	892	298	V	L	Gta/Tta	-3.42	0	0	benign	0.05	neutral	0.78	neutral	4.86	neutral	0.81	neutral	-1.14	neutral_impact	0.06	0.73	neutral	0.57	neutral	1.84	15.21	deleterious	0.2	0.45	0.4	neutral	0.41	neutral	0.34	neutral	0.46	neutral	1	0.14	neutral	0.87	deleterious	-6	neutral	0.18	neutral	0.48	medium_impact	0.51	medium_impact	-1.07	low_impact	0.50	0.8	28.54	8.66	0.27	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11652	11652	T	G	MI.18198	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	893	298	V	G	gTa/gGa	3.02	0.35	0	benign	0.34	deleterious	0.03	neutral	4.59	deleterious	-3.53	deleterious	-5.33	medium_impact	2.29	0.71	neutral	0.51	neutral	3.47	23.00	deleterious	0.03	0.35	0.82	disease	0.67	disease	0.58	disease	0.69	disease	4	0.97	neutral	0.35	neutral	1	deleterious	0.60	deleterious	-0.45	medium_impact	-0.64	medium_impact	1.14	medium_impact	0.24	0.8	28.54	8.66	0.36	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11652	11652	T	C	MI.18199	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	893	298	V	A	gTa/gCa	3.02	0.35	0	benign	0.18	neutral	0.57	neutral	4.65	neutral	-0.99	neutral	-2.37	neutral_impact	0.74	0.68	neutral	0.67	neutral	-0.18	1.23	neutral	0.13	0.4	0.57	disease	0.19	neutral	0.35	neutral	0.47	neutral	1	0.32	neutral	0.7	deleterious	-6	neutral	0.31	neutral	-0.1	medium_impact	0.27	medium_impact	-0.39	medium_impact	0.21	0.8	28.54	8.66	0.34	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8611	8611	C	A	MI.182	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	85	29	L	M	Cta/Ata	-6.12	0	0	probably_damaging	1	neutral	0.44	neutral	4.29	neutral	-1.85	neutral	-0.6	low_impact	1.49	0.87	neutral	0.83	neutral	2.22	17.67	deleterious	0.38	0.65	0.64	disease	0.14	neutral	0.18	neutral	0.4	neutral	2	1	deleterious	0.22	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.23	medium_impact	0.18	medium_impact	0.65	0.9	17.26	17.02	0.45	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8542	8542	T	G	MI.1820	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	177	59	C	W	tgT/tgG	0.13	0.97	0	benign	0.01	neutral	0.18	neutral	1.94	neutral	-2.56	neutral	1.76	low_impact	1.38	0.99	neutral	0.51	neutral	3.95	23.60	deleterious	0.46155204	0.85	0.62	disease	0.49	neutral	0.69	disease	0.62	disease	2	0.82	neutral	0.59	deleterious	-6	neutral	0.27	neutral	1.14	medium_impact	-0.08	medium_impact	0.09	medium_impact	0.32	0.85	19.12	7.68	0.51	N	0.12	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11652	11652	T	A	MI.18200	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	893	298	V	E	gTa/gAa	3.02	0.35	0	possibly_damaging	0.47	deleterious	0.02	neutral	4.56	deleterious	-4.3	deleterious	-4.7	medium_impact	2.63	0.72	neutral	0.5	neutral	4.52	24.30	deleterious	0.03	0.35	0.7	disease	0.84	disease	0.69	disease	0.78	disease	6	0.98	neutral	0.28	neutral	4	deleterious	0.75	deleterious	-0.67	medium_impact	-0.75	medium_impact	1.48	medium_impact	0.16	0.8	28.54	8.66	0.38	N	0.94	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11654	11654	A	C	MI.18201	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	895	299	T	P	Aca/Cca	-6.88	0	0	benign	0.11	deleterious	0.03	neutral	4.58	neutral	-2.36	neutral	-1.61	low_impact	1.58	0.68	neutral	0.47	neutral	1.68	14.30	neutral	0.04	0.35	0.79	disease	0.81	disease	0.66	disease	0.77	disease	5	0.97	neutral	0.46	neutral	-2	neutral	0.34	neutral	0.14	medium_impact	-0.64	medium_impact	0.44	medium_impact	0.33	0.8	31.15	23.21	0.29	N	0.70	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11654	11654	A	G	MI.18202	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	895	299	T	A	Aca/Gca	-6.88	0	0	benign	0	neutral	1	neutral	4.69	neutral	0.69	neutral	1.05	neutral_impact	-1.48	0.76	neutral	0.99	neutral	-1.11	0.01	neutral	0.19	0.45	0.37	neutral	0.08	neutral	0.23	neutral	0.25	neutral	5	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	1.88	high_impact	-2.59	low_impact	0.27	0.8	31.15	23.21	0.32	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11654	11654	A	T	MI.18203	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	895	299	T	S	Aca/Tca	-6.88	0	0	benign	0.04	neutral	0.27	neutral	4.63	neutral	-0.4	neutral	-0.45	neutral_impact	-0.61	0.75	neutral	0.83	neutral	0.06	3.22	deleterious	0.29	0.45	0.43	neutral	0.31	neutral	0.27	neutral	0.47	neutral	1	0.71	neutral	0.62	deleterious	-6	neutral	0.14	neutral	0.58	medium_impact	-0.04	medium_impact	-1.73	low_impact	0.55	0.8	31.15	23.21	0.42	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11655	11655	C	A	MI.18204	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	896	299	T	K	aCa/aAa	0.72	0	0	benign	0.06	deleterious	0.03	neutral	4.59	neutral	-1.76	neutral	-1.51	low_impact	1.94	0.71	neutral	0.56	neutral	2.62	20.30	deleterious	0.05	0.35	0.37	neutral	0.67	disease	0.65	disease	0.72	disease	4	0.97	neutral	0.49	deleterious	-2	neutral	0.21	neutral	0.41	medium_impact	-0.64	medium_impact	0.79	medium_impact	0.46	0.8	31.15	23.21	0.4	N	0.64	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11655	11655	C	T	MI.18205	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	896	299	T	M	aCa/aTa	0.72	0	0	benign	0.01	neutral	0.23	neutral	4.82	neutral	1.78	neutral	-0.11	neutral_impact	-0.34	0.78	neutral	0.96	neutral	1.07	11.07	neutral	0.09	0.4	0.65	disease	0.42	neutral	0.32	neutral	0.61	disease	2	0.77	neutral	0.61	deleterious	-6	neutral	0.35	neutral	1.16	medium_impact	-0.09	medium_impact	-1.46	low_impact	0.48	0.8	31.15	23.21	0.37	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11657	11657	G	A	MI.18206	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	898	300	A	T	Gcc/Acc	-2.5	0	0	probably_damaging	0.95	neutral	0.05	neutral	4.54	deleterious	-3.23	deleterious	-3.42	medium_impact	2.22	0.75	neutral	0.52	neutral	4.31	24.00	deleterious	0.09	0.35	0.32	neutral	0.76	disease	0.54	disease	0.55	disease	1	0.99	deleterious	0.05	neutral	1	deleterious	0.75	deleterious	-1.92	low_impact	-0.52	medium_impact	1.07	medium_impact	0.75	0.85	34.86	8.76	0.42	N	0.84	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11657	11657	G	C	MI.18207	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	898	300	A	P	Gcc/Ccc	-2.5	0	0	probably_damaging	0.99	deleterious	0	neutral	4.48	deleterious	-4.47	deleterious	-4.25	high_impact	3.92	0.69	neutral	0.25	damaging	3.93	23.50	deleterious	0.02	0.35	0.76	disease	0.92	disease	0.74	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.59	low_impact	-1.48	low_impact	2.75	high_impact	0.61	0.8	34.86	8.76	0.37	N	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11657	11657	G	T	MI.18208	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	898	300	A	S	Gcc/Tcc	-2.5	0	0	possibly_damaging	0.86	neutral	0.13	neutral	4.57	deleterious	-3.12	neutral	-2.33	low_impact	1.94	0.79	neutral	0.72	neutral	3.73	23.30	deleterious	0.16	0.45	0.46	neutral	0.78	disease	0.4	neutral	0.39	neutral	2	0.94	neutral	0.14	neutral	-3	neutral	0.78	deleterious	-1.46	low_impact	-0.26	medium_impact	0.79	medium_impact	0.58	0.8	34.86	8.76	0.41	N	0.31	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11658	11658	C	A	MI.18209	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	899	300	A	D	gCc/gAc	5.09	1	0	probably_damaging	0.98	deleterious	0	neutral	4.48	deleterious	-5.18	deleterious	-4.87	high_impact	3.92	0.72	neutral	0.32	neutral	4.70	24.60	deleterious	0.02	0.35	0.52	disease	0.92	disease	0.72	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.31	low_impact	-1.48	low_impact	2.75	high_impact	0.36	0.8	34.86	8.76	0.58	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8543	8543	T	A	MI.1821	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	178	60	S	T	Tcg/Acg	4.76	1	0	possibly_damaging	0.85	neutral	0.58	neutral	1.79	neutral	-1.59	neutral	-1.26	medium_impact	2.29	1	neutral	0.5	neutral	4.13	23.80	deleterious	0.42653776	0.85	0.38	neutral	0.22	neutral	0.53	disease	0.2	neutral	6	0.82	neutral	0.37	neutral	0	NA	0.59	deleterious	-1.47	low_impact	0.37	medium_impact	0.87	medium_impact	0.62	0.85	NA	NA	0.58	P	0.26	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11658	11658	C	G	MI.18210	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	899	300	A	G	gCc/gGc	5.09	1	0	benign	0.15	neutral	1	neutral	4.66	neutral	0.52	neutral	-2.24	low_impact	0.91	0.63	neutral	0.62	neutral	2.03	16.40	deleterious	0.17	0.45	0.63	disease	0.2	neutral	0.34	neutral	0.48	neutral	0	0.15	neutral	0.93	deleterious	-6	neutral	0.72	deleterious	-0.01	medium_impact	1.88	high_impact	-0.23	medium_impact	0.62	0.8	34.86	8.76	0.5	P	0.60	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11658	11658	C	T	MI.18211	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	899	300	A	V	gCc/gTc	5.09	1	0	probably_damaging	0.96	deleterious	0	neutral	4.63	neutral	-2.66	deleterious	-3.61	medium_impact	3.23	0.76	neutral	0.44	neutral	4.51	24.30	deleterious	0.05	0.35	0.72	disease	0.85	disease	0.6	disease	0.7	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-2.01	low_impact	-1.48	low_impact	2.07	high_impact	0.65	0.8	34.86	8.76	0.58	P	0.85	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11660	11660	A	G	MI.18212	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	901	301	I	V	Att/Gtt	-12.86	0	0	benign	0.01	neutral	0.13	neutral	4.45	neutral	-0.51	neutral	-0.48	low_impact	1.16	0.81	neutral	0.99	neutral	0.03	2.92	deleterious	0.54	0.6	0.51	disease	0.24	neutral	0.39	neutral	0.34	neutral	3	0.87	neutral	0.56	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	-0.26	medium_impact	0.02	medium_impact	0.51	0.8	26.58	22.22	0.39	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11660	11660	A	T	MI.18213	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	901	301	I	F	Att/Ttt	-12.86	0	0	possibly_damaging	0.55	neutral	0.06	neutral	4.39	neutral	-1.48	deleterious	-3.09	medium_impact	2.14	0.69	neutral	0.43	neutral	3.73	23.30	deleterious	0.14	0.4	0.75	disease	0.7	disease	0.61	disease	0.69	disease	4	0.94	neutral	0.26	neutral	0	NA	0.61	deleterious	-0.8	medium_impact	-0.47	medium_impact	0.99	medium_impact	0.66	0.8	26.58	22.22	0.34	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11660	11660	A	C	MI.18214	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	901	301	I	L	Att/Ctt	-12.86	0	0	benign	0.12	neutral	0.56	neutral	4.49	neutral	0.69	neutral	-1.41	neutral_impact	0.32	0.73	neutral	0.64	neutral	1.95	15.93	deleterious	0.28	0.45	0.56	disease	0.42	neutral	0.38	neutral	0.6	disease	2	0.35	neutral	0.72	deleterious	-6	neutral	0.18	neutral	0.1	medium_impact	0.26	medium_impact	-0.81	medium_impact	0.59	0.8	26.58	22.22	0.29	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11661	11661	T	A	MI.18215	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	902	301	I	N	aTt/aAt	0.26	0	0	benign	0.38	deleterious	0.01	neutral	4.32	deleterious	-4.65	deleterious	-5.03	high_impact	3.62	0.66	neutral	0.45	neutral	4.31	24.00	deleterious	0.05	0.35	0.77	disease	0.74	disease	0.62	disease	0.69	disease	4	0.99	deleterious	0.32	neutral	2	deleterious	0.71	deleterious	-0.52	medium_impact	-0.92	medium_impact	2.46	high_impact	0.35	0.8	26.58	22.22	0.33	N	0.87	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11661	11661	T	G	MI.18216	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	902	301	I	S	aTt/aGt	0.26	0	0	benign	0.01	neutral	0.07	neutral	4.39	deleterious	-3.32	deleterious	-3.79	low_impact	1.42	0.74	neutral	0.76	neutral	1.64	14.05	neutral	0.02	0.35	0.48	neutral	0.64	disease	0.44	neutral	0.35	neutral	3	0.93	neutral	0.53	deleterious	-6	neutral	0.45	deleterious	1.16	medium_impact	-0.43	medium_impact	0.28	medium_impact	0.33	0.8	26.58	22.22	0.44	N	0.36	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11661	11661	T	C	MI.18217	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	902	301	I	T	aTt/aCt	0.26	0	0	benign	0.18	neutral	0.12	neutral	4.39	neutral	-2.81	deleterious	-3	low_impact	1.28	0.7	neutral	0.74	neutral	0.51	7.48	deleterious	0.05	0.35	0.71	disease	0.34	neutral	0.4	neutral	0.64	disease	3	0.86	neutral	0.47	deleterious	-6	neutral	0.41	neutral	-0.1	medium_impact	-0.28	medium_impact	0.14	medium_impact	0.29	0.8	26.58	22.22	0.44	N	0.53	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11662	11662	T	A	MI.18218	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	903	301	I	M	atT/atA	0.95	0	0	possibly_damaging	0.73	neutral	0.17	neutral	4.39	neutral	-2.4	neutral	-2.07	low_impact	1.66	0.7	neutral	0.48	neutral	3.55	23.10	deleterious	0.22	0.45	0.79	disease	0.42	neutral	0.61	disease	0.67	disease	3	0.87	neutral	0.22	neutral	-3	neutral	0.59	deleterious	-1.12	low_impact	-0.18	medium_impact	0.52	medium_impact	0.61	0.8	26.58	22.22	0.37	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11662	11662	T	G	MI.18219	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	903	301	I	M	atT/atG	0.95	0	0	possibly_damaging	0.73	neutral	0.17	neutral	4.39	neutral	-2.4	neutral	-2.07	low_impact	1.66	0.7	neutral	0.48	neutral	3.20	22.70	deleterious	0.22	0.45	0.79	disease	0.42	neutral	0.61	disease	0.67	disease	3	0.87	neutral	0.22	neutral	-3	neutral	0.59	deleterious	-1.12	low_impact	-0.18	medium_impact	0.52	medium_impact	0.61	0.8	26.58	22.22	0.37	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8543	8543	T	C	MI.1822	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	178	60	S	P	Tcg/Ccg	4.76	1	0	probably_damaging	0.94	neutral	0.28	neutral	1.74	deleterious	-3.17	neutral	-2.12	medium_impact	2.64	1	neutral	0.28	damaging	4.15	23.80	deleterious	0.30302861	0.85	0.61	disease	0.48	neutral	0.55	disease	0.4	neutral	2	0.95	neutral	0.17	neutral	1	deleterious	0.70	deleterious	-1.89	low_impact	0.06	medium_impact	1.17	medium_impact	0.36	0.85	NA	NA	0.63	P	0.54	polymorphism	0.95	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11663	11663	C	G	MI.18220	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	904	302	L	V	Ctc/Gtc	-9.18	0	0	possibly_damaging	0.86	neutral	0.11	neutral	4.37	neutral	-0.31	neutral	-2.38	medium_impact	2.02	0.73	neutral	0.57	neutral	3.51	23.10	deleterious	0.32	0.5	0.66	disease	0.6	disease	0.55	disease	0.51	disease	0	0.95	neutral	0.13	neutral	0	NA	0.76	deleterious	-1.46	low_impact	-0.31	medium_impact	0.87	medium_impact	0.55	0.8	18.3	20.92	0.35	N	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11663	11663	C	T	MI.18221	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	904	302	L	F	Ctc/Ttc	-9.18	0	0	benign	0.29	neutral	0.41	neutral	4.31	neutral	-0.22	deleterious	-3.29	low_impact	1.27	0.74	neutral	0.64	neutral	4.06	23.70	deleterious	0.27	0.45	0.81	disease	0.62	disease	0.43	neutral	0.48	neutral	0	0.51	neutral	0.56	deleterious	-6	neutral	0.80	deleterious	-0.35	medium_impact	0.11	medium_impact	0.13	medium_impact	0.48	0.8	18.3	20.92	0.23	N	0.56	polymorphism	1	0.07	rs28588274	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11663	11663	C	A	MI.18222	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	904	302	L	I	Ctc/Atc	-9.18	0	0	possibly_damaging	0.86	neutral	0.16	neutral	4.4	neutral	-0.55	neutral	-1.66	low_impact	1.8	0.73	neutral	0.71	neutral	4.15	23.80	deleterious	0.36	0.5	0.7	disease	0.63	disease	0.41	neutral	0.39	neutral	2	0.93	neutral	0.15	neutral	-3	neutral	0.77	deleterious	-1.46	low_impact	-0.2	medium_impact	0.66	medium_impact	0.53	0.8	18.3	20.92	0.38	N	0.46	polymorphism	1	0.03	rs28588274	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11664	11664	T	A	MI.18223	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	905	302	L	H	cTc/cAc	-1.35	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.22	deleterious	-3.74	deleterious	-5.93	high_impact	3.79	0.69	neutral	0.44	neutral	4.11	23.70	deleterious	0.03	0.35	0.9	disease	0.81	disease	0.71	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.59	low_impact	-0.92	medium_impact	2.62	high_impact	0.17	0.8	18.3	20.92	0.34	N	0.89	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11664	11664	T	G	MI.18224	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	905	302	L	R	cTc/cGc	-1.35	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.23	deleterious	-3.28	deleterious	-5	high_impact	3.79	0.68	neutral	0.39	neutral	4.23	23.90	deleterious	0.02	0.35	0.85	disease	0.89	disease	0.74	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.59	low_impact	-0.92	medium_impact	2.62	high_impact	0.14	0.8	18.3	20.92	0.34	N	0.95	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11664	11664	T	C	MI.18225	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	905	302	L	P	cTc/cCc	-1.35	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.22	deleterious	-3.71	deleterious	-5.95	high_impact	3.79	0.65	neutral	0.38	neutral	3.98	23.60	deleterious	0.01	0.35	0.9	disease	0.86	disease	0.74	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.59	low_impact	-0.92	medium_impact	2.62	high_impact	0.18	0.8	18.3	20.92	0.35	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11666	11666	A	C	MI.18226	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	907	303	I	L	Atc/Ctc	-5.96	0	0	probably_damaging	1	neutral	0.29	neutral	4.65	neutral	0.46	neutral	-1.6	low_impact	1.25	0.79	neutral	0.72	neutral	3.86	23.50	deleterious	0.23	0.45	0.35	neutral	0.62	disease	0.45	neutral	0.34	neutral	3	1	deleterious	0.15	neutral	-2	neutral	0.63	deleterious	-3.54	low_impact	-0.02	medium_impact	0.11	medium_impact	0.35	0.8	18.3	19.83	0.37	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11666	11666	A	G	MI.18227	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	907	303	I	V	Atc/Gtc	-5.96	0	0	probably_damaging	1	neutral	0.29	neutral	4.68	neutral	0.37	neutral	-0.79	low_impact	1.92	0.74	neutral	0.42	neutral	3.10	22.50	deleterious	0.44	0.55	0.59	disease	0.41	neutral	0.48	neutral	0.59	disease	2	1	deleterious	0.15	neutral	-2	neutral	0.65	deleterious	-3.54	low_impact	-0.02	medium_impact	0.77	medium_impact	0.29	0.8	18.3	19.83	0.39	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11666	11666	A	T	MI.18228	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	907	303	I	F	Atc/Ttc	-5.96	0	0	probably_damaging	1	neutral	0.15	neutral	4.63	neutral	-1.92	deleterious	-3.49	medium_impact	3.27	0.66	neutral	0.13	damaging	3.87	23.50	deleterious	0.2	0.45	0.58	disease	0.82	disease	0.69	disease	0.69	disease	4	1	deleterious	0.08	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.22	medium_impact	2.11	high_impact	0.44	0.8	18.3	19.83	0.32	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11667	11667	T	G	MI.18229	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	908	303	I	S	aTc/aGc	5.55	0.99	0	probably_damaging	1	neutral	0.63	neutral	4.85	neutral	-0.92	deleterious	-5.13	neutral_impact	0.61	0.74	neutral	0.24	damaging	4.36	24.10	deleterious	0.05	0.35	0.69	disease	0.78	disease	0.5	neutral	0.41	neutral	2	1	deleterious	0.32	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	0.33	medium_impact	-0.52	medium_impact	0.13	0.8	18.3	19.83	0.45	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8543	8543	T	G	MI.1823	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	178	60	S	A	Tcg/Gcg	4.76	1	0	possibly_damaging	0.78	neutral	0.76	neutral	1.81	neutral	-1.08	neutral	-1.26	medium_impact	2.64	1	neutral	0.59	neutral	4.06	23.70	deleterious	0.55192990	0.85	0.27	neutral	0.18	neutral	0.56	disease	0.2	neutral	6	0.73	neutral	0.49	deleterious	0	NA	0.52	deleterious	-1.28	low_impact	0.57	medium_impact	1.17	medium_impact	0.46	0.85	NA	NA	0.55	P	0.26	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11667	11667	T	A	MI.18230	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	908	303	I	N	aTc/aAc	5.55	0.99	0	probably_damaging	1	neutral	0.1	neutral	4.66	deleterious	-4.02	deleterious	-6.08	medium_impact	2.37	0.65	neutral	0.13	damaging	4.54	24.30	deleterious	0.09	0.35	0.79	disease	0.84	disease	0.69	disease	0.71	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.33	medium_impact	1.22	medium_impact	0.15	0.8	18.3	19.83	0.53	P	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11667	11667	T	C	MI.18231	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	908	303	I	T	aTc/aCc	5.55	0.99	0	probably_damaging	1	neutral	0.73	neutral	4.68	neutral	-1.27	deleterious	-4.13	neutral_impact	0.32	0.73	neutral	0.35	neutral	2.35	18.48	deleterious	0.12	0.4	0.56	disease	0.38	neutral	0.47	neutral	0.58	disease	2	1	deleterious	0.37	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.44	medium_impact	-0.81	medium_impact	0.24	0.8	18.3	19.83	0.51	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11668	11668	C	A	MI.18232	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	909	303	I	M	atC/atA	2.33	0.98	0	probably_damaging	1	neutral	0.09	neutral	4.63	neutral	-1.45	neutral	-2.26	medium_impact	2.06	0.81	neutral	0.42	neutral	2.82	21.50	deleterious	0.28	0.45	0.47	neutral	0.56	disease	0.57	disease	0.46	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.69	deleterious	-3.54	low_impact	-0.36	medium_impact	0.91	medium_impact	0.42	0.8	18.3	19.83	0.52	P	0.43	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11668	11668	C	G	MI.18233	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	909	303	I	M	atC/atG	2.33	0.98	0	probably_damaging	1	neutral	0.09	neutral	4.63	neutral	-1.45	neutral	-2.26	medium_impact	2.06	0.81	neutral	0.42	neutral	2.37	18.63	deleterious	0.28	0.45	0.47	neutral	0.56	disease	0.57	disease	0.46	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.69	deleterious	-3.54	low_impact	-0.36	medium_impact	0.91	medium_impact	0.42	0.8	18.3	19.83	0.51	N	0.43	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11669	11669	C	G	MI.18234	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	910	304	Q	E	Caa/Gaa	-5.04	0	0	possibly_damaging	0.64	neutral	0.4	neutral	4.61	neutral	-1.18	deleterious	-2.75	medium_impact	3	0.7	neutral	0.42	neutral	3.21	22.70	deleterious	0.37	0.5	0.72	disease	0.82	disease	0.74	disease	0.71	disease	4	0.67	neutral	0.38	neutral	0	NA	0.82	deleterious	-0.95	medium_impact	0.1	medium_impact	1.84	medium_impact	0.41	0.8	45.75	9.12	0.31	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11669	11669	C	A	MI.18235	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	910	304	Q	K	Caa/Aaa	-5.04	0	0	benign	0.08	neutral	0.41	neutral	4.62	neutral	-0.94	deleterious	-3.7	medium_impact	2.46	0.74	neutral	0.44	neutral	4.04	23.70	deleterious	0.24	0.45	0.34	neutral	0.86	disease	0.55	disease	0.55	disease	1	0.54	neutral	0.67	deleterious	-3	neutral	0.75	deleterious	0.28	medium_impact	0.11	medium_impact	1.31	medium_impact	0.33	0.8	45.75	9.12	0.33	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11670	11670	A	C	MI.18236	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	911	304	Q	P	cAa/cCa	5.32	1	0	probably_damaging	0.96	neutral	0.24	neutral	4.61	neutral	-1.75	deleterious	-5.57	medium_impact	3.26	0.73	neutral	0.44	neutral	3.46	23.00	deleterious	0.03	0.35	0.92	disease	0.91	disease	0.78	disease	0.74	disease	5	0.97	neutral	0.14	neutral	1	deleterious	0.91	deleterious	-2.01	low_impact	-0.08	medium_impact	2.1	high_impact	0.18	0.8	45.75	9.12	0.65	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11670	11670	A	G	MI.18237	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	911	304	Q	R	cAa/cGa	5.32	1	0	possibly_damaging	0.74	neutral	0.42	neutral	4.62	neutral	-1.08	deleterious	-3.67	medium_impact	2.66	0.69	neutral	0.48	neutral	3.52	23.10	deleterious	0.22	0.45	0.79	disease	0.86	disease	0.59	disease	0.63	disease	3	0.75	neutral	0.34	neutral	0	NA	0.85	deleterious	-1.14	low_impact	0.12	medium_impact	1.51	medium_impact	0.11	0.8	45.75	9.12	0.6	P	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11670	11670	A	T	MI.18238	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	911	304	Q	L	cAa/cTa	5.32	1	0	possibly_damaging	0.88	neutral	0.74	neutral	4.89	neutral	2.62	deleterious	-6.52	low_impact	1.44	0.73	neutral	0.44	neutral	3.94	23.50	deleterious	0.07	0.35	0.68	disease	0.84	disease	0.57	disease	0.48	neutral	0	0.85	neutral	0.43	neutral	-3	neutral	0.82	deleterious	-1.53	low_impact	0.46	medium_impact	0.3	medium_impact	0.12	0.8	45.75	9.12	0.44	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11671	11671	A	C	MI.18239	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	912	304	Q	H	caA/caC	5.55	1	0	probably_damaging	0.98	neutral	0.57	neutral	4.61	neutral	-1.68	deleterious	-4.32	medium_impact	2.91	0.78	neutral	0.47	neutral	3.42	23.00	deleterious	0.24	0.45	0.9	disease	0.8	disease	0.66	disease	0.69	disease	4	0.97	neutral	0.3	neutral	1	deleterious	0.86	deleterious	-2.31	low_impact	0.27	medium_impact	1.75	medium_impact	0.40	0.8	45.75	9.12	0.53	P	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8544	8544	C	G	MI.1824	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	179	60	S	W	tCg/tGg	5.91	1	0	probably_damaging	0.98	deleterious	0.02	neutral	1.73	deleterious	-4.7	deleterious	-3.34	medium_impact	2.64	1	neutral	0.37	neutral	4.30	24.00	deleterious	0.21080113	0.85	0.83	disease	0.43	neutral	0.63	disease	0.29	neutral	4	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-2.36	low_impact	-0.66	medium_impact	1.17	medium_impact	0.17	0.85	NA	NA	0.64	P	0.53	disease_causing	0.99	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11671	11671	A	T	MI.18240	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	912	304	Q	H	caA/caT	5.55	1	0	probably_damaging	0.98	neutral	0.57	neutral	4.61	neutral	-1.68	deleterious	-4.32	medium_impact	2.91	0.78	neutral	0.47	neutral	3.65	23.20	deleterious	0.24	0.45	0.9	disease	0.8	disease	0.66	disease	0.69	disease	4	0.97	neutral	0.3	neutral	1	deleterious	0.86	deleterious	-2.31	low_impact	0.27	medium_impact	1.75	medium_impact	0.40	0.8	45.75	9.12	0.53	P	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11672	11672	A	T	MI.18241	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	913	305	T	S	Acc/Tcc	3.25	1	0	probably_damaging	1	neutral	0.48	neutral	4.6	neutral	-1.19	deleterious	-3.37	low_impact	1.72	0.79	neutral	0.85	neutral	2.17	17.33	deleterious	0.35	0.5	0.65	disease	0.58	disease	0.37	neutral	0.36	neutral	3	1	deleterious	0.24	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	0.18	medium_impact	0.58	medium_impact	0.57	0.8	15.69	16.36	0.46	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11672	11672	A	G	MI.18242	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	913	305	T	A	Acc/Gcc	3.25	1	0	probably_damaging	1	deleterious	0.03	neutral	4.55	neutral	-1.92	deleterious	-4.44	medium_impact	3.38	0.69	neutral	0.15	damaging	3.48	23.10	deleterious	0.2	0.45	0.55	disease	0.7	disease	0.67	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.71	deleterious	-3.54	low_impact	-0.64	medium_impact	2.22	high_impact	0.26	0.8	15.69	16.36	0.52	P	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11672	11672	A	C	MI.18243	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	913	305	T	P	Acc/Ccc	3.25	1	0	probably_damaging	1	deleterious	0.01	neutral	4.49	deleterious	-4.23	deleterious	-5.42	high_impact	3.84	0.68	neutral	0.14	damaging	3.51	23.10	deleterious	0.04	0.35	0.88	disease	0.88	disease	0.55	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-0.92	medium_impact	2.67	high_impact	0.32	0.8	15.69	16.36	0.5	P	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11673	11673	C	A	MI.18244	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	914	305	T	N	aCc/aAc	3.71	1	0	probably_damaging	1	neutral	0.27	neutral	4.66	neutral	-1.67	deleterious	-4.44	low_impact	1.73	0.69	neutral	0.17	damaging	3.91	23.50	deleterious	0.29	0.45	0.85	disease	0.75	disease	0.57	disease	0.59	disease	2	1	deleterious	0.14	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	-0.04	medium_impact	0.59	medium_impact	0.47	0.8	15.69	16.36	0.51	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11673	11673	C	G	MI.18245	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	914	305	T	S	aCc/aGc	3.71	1	0	probably_damaging	1	neutral	0.48	neutral	4.6	neutral	-1.19	deleterious	-3.37	low_impact	1.72	0.79	neutral	0.85	neutral	2.52	19.57	deleterious	0.35	0.5	0.65	disease	0.58	disease	0.37	neutral	0.36	neutral	3	1	deleterious	0.24	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	0.18	medium_impact	0.58	medium_impact	0.57	0.8	15.69	16.36	0.49	P	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11673	11673	C	T	MI.18246	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	914	305	T	I	aCc/aTc	3.71	1	0	probably_damaging	1	neutral	0.12	neutral	4.51	deleterious	-4.04	deleterious	-5.51	medium_impact	3.29	0.73	neutral	0.11	damaging	4.03	23.60	deleterious	0.09	0.35	0.35	neutral	0.88	disease	0.7	disease	0.72	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.28	medium_impact	2.13	high_impact	0.36	0.8	15.69	16.36	0.5	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11675	11675	C	A	MI.18247	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	916	306	P	T	Ccc/Acc	-7.57	0	0	probably_damaging	1	neutral	0.39	neutral	4.67	neutral	-1.53	deleterious	-6.75	medium_impact	2.06	0.79	neutral	0.59	neutral	3.76	23.30	deleterious	0.23	0.45	0.53	disease	0.59	disease	0.37	neutral	0.36	neutral	3	1	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.09	medium_impact	0.91	medium_impact	0.46	0.8	11.98	17.11	0.28	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11675	11675	C	G	MI.18248	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	916	306	P	A	Ccc/Gcc	-7.57	0	0	probably_damaging	1	neutral	0.49	neutral	4.76	neutral	-0.52	deleterious	-7.03	medium_impact	2.44	0.75	neutral	0.52	neutral	3.21	22.70	deleterious	0.21	0.45	0.35	neutral	0.58	disease	0.56	disease	0.51	disease	0	1	deleterious	0.25	neutral	1	deleterious	0.71	deleterious	-3.54	low_impact	0.19	medium_impact	1.29	medium_impact	0.64	0.8	11.98	17.11	0.3	N	0.59	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11675	11675	C	T	MI.18249	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	916	306	P	S	Ccc/Tcc	-7.57	0	0	probably_damaging	1	neutral	0.41	neutral	4.77	neutral	-0.98	deleterious	-6.95	low_impact	1.31	0.76	neutral	0.55	neutral	4.00	23.60	deleterious	0.28	0.45	0.42	neutral	0.68	disease	0.37	neutral	0.36	neutral	3	1	deleterious	0.21	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	0.11	medium_impact	0.17	medium_impact	0.14	0.8	11.98	17.11	0.28	N	0.54	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8544	8544	C	T	MI.1825	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	179	60	S	L	tCg/tTg	5.91	1	0	possibly_damaging	0.9	neutral	0.34	neutral	2.09	neutral	1.02	neutral	-0.88	neutral_impact	-0.36	0.99	neutral	0.96	neutral	1.92	15.69	deleterious	0.39005501	0.85	0.13	neutral	0.12	neutral	0.23	neutral	0.07	neutral	9	0.91	neutral	0.22	neutral	-3	neutral	0.60	deleterious	-1.66	low_impact	0.13	medium_impact	-1.41	low_impact	0.61	0.85	NA	NA	0.61	P	0.13	polymorphism	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11676	11676	C	A	MI.18250	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	917	306	P	H	cCc/cAc	2.1	0.84	0	probably_damaging	1	neutral	0.54	neutral	4.63	neutral	-2.76	deleterious	-8.02	medium_impact	2.42	0.72	neutral	0.54	neutral	4.17	23.80	deleterious	0.09	0.35	0.8	disease	0.76	disease	0.68	disease	0.6	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.24	medium_impact	1.27	medium_impact	0.24	0.8	11.98	17.11	0.33	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11676	11676	C	G	MI.18251	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	917	306	P	R	cCc/cGc	2.1	0.84	0	probably_damaging	1	neutral	0.34	neutral	4.66	neutral	-1.85	deleterious	-7.97	medium_impact	3	0.74	neutral	0.37	neutral	3.75	23.30	deleterious	0.08	0.35	0.75	disease	0.87	disease	0.78	disease	0.73	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.82	deleterious	-3.54	low_impact	0.04	medium_impact	1.84	medium_impact	0.26	0.8	11.98	17.11	0.43	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11676	11676	C	T	MI.18252	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	917	306	P	L	cCc/cTc	2.1	0.84	0	probably_damaging	1	neutral	0.64	neutral	4.72	neutral	-2.22	deleterious	-8.87	medium_impact	2.05	0.71	neutral	0.4	neutral	4.55	24.40	deleterious	0.16	0.45	0.57	disease	0.8	disease	0.64	disease	0.57	disease	1	1	deleterious	0.32	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.34	medium_impact	0.9	medium_impact	0.56	0.8	11.98	17.11	0.32	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11678	11678	T	C	MI.18253	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	919	307	W	R	Tga/Cga	-3.89	0	0	benign	0.17	deleterious	0.02	neutral	4.6	neutral	-1.13	deleterious	-10.97	high_impact	3.61	0.69	neutral	0.3	neutral	3.67	23.20	deleterious	0.04	0.35	0.77	disease	0.93	disease	0.82	disease	0.8	disease	6	0.98	neutral	0.43	neutral	2	deleterious	0.87	deleterious	-0.07	medium_impact	-0.75	medium_impact	2.45	high_impact	0.06	0.8	15.03	20.18	0.41	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11678	11678	T	G	MI.18254	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	919	307	W	G	Tga/Gga	-3.89	0	0	probably_damaging	0.91	deleterious	0.03	neutral	4.59	neutral	-1.59	deleterious	-10.52	high_impact	3.61	0.68	neutral	0.45	neutral	4.03	23.70	deleterious	0.05	0.35	0.67	disease	0.89	disease	0.79	disease	0.74	disease	5	0.99	deleterious	0.06	neutral	6	deleterious	0.79	deleterious	-1.66	low_impact	-0.64	medium_impact	2.45	high_impact	0.04	0.8	15.03	20.18	0.46	N	0.91	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11679	11679	G	C	MI.18255	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	920	307	W	S	tGa/tCa	3.71	1	0	probably_damaging	0.94	neutral	0.11	neutral	4.68	neutral	0.59	deleterious	-10.97	medium_impact	2.13	0.73	neutral	0.49	neutral	4.14	23.80	deleterious	0.08	0.35	0.48	neutral	0.91	disease	0.67	disease	0.46	neutral	1	0.98	neutral	0.09	neutral	1	deleterious	0.81	deleterious	-1.84	low_impact	-0.31	medium_impact	0.98	medium_impact	0.09	0.8	15.03	20.18	0.51	P	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11679	11679	G	T	MI.18256	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	920	307	W	L	tGa/tTa	3.71	1	0	possibly_damaging	0.88	neutral	0.17	neutral	4.67	neutral	0.49	deleterious	-9.27	low_impact	1.42	0.76	neutral	0.71	neutral	3.22	22.70	deleterious	0.09	0.35	0.69	disease	0.82	disease	0.63	disease	0.45	neutral	1	0.93	neutral	0.15	neutral	-3	neutral	0.75	deleterious	-1.53	low_impact	-0.18	medium_impact	0.28	medium_impact	0.04	0.8	15.03	20.18	0.53	P	0.54	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11680	11680	A	C	MI.18257	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	921	307	W	C	tgA/tgC	3.48	1	0	probably_damaging	0.98	deleterious	0.02	neutral	4.58	neutral	-2.5	deleterious	-10.05	medium_impact	3.47	0.69	neutral	0.32	neutral	4.14	23.80	deleterious	0.05	0.35	0.81	disease	0.92	disease	0.8	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-2.31	low_impact	-0.75	medium_impact	2.31	high_impact	0.08	0.8	15.03	20.18	0.56	P	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11680	11680	A	T	MI.18258	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	921	307	W	C	tgA/tgT	3.48	1	0	probably_damaging	0.98	deleterious	0.02	neutral	4.58	neutral	-2.5	deleterious	-10.05	medium_impact	3.47	0.69	neutral	0.32	neutral	4.25	23.90	deleterious	0.05	0.35	0.81	disease	0.92	disease	0.8	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-2.31	low_impact	-0.75	medium_impact	2.31	high_impact	0.08	0.8	15.03	20.18	0.57	P	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11681	11681	A	T	MI.18259	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	922	308	S	C	Agc/Tgc	2.1	1	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-4.46	deleterious	-4.29	high_impact	3.86	0.65	neutral	0.05	damaging	3.62	23.20	deleterious	0.05	0.35	0.9	disease	0.86	disease	0.54	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.69	high_impact	0.41	0.8	44.66	8.21	0.46	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8546	8546	C	T	MI.1826	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	181	61	L	F	Ctt/Ttt	-0.33	0	0	probably_damaging	0.96	neutral	0.14	neutral	1.82	neutral	-2.67	neutral	-1.16	low_impact	1.36	1	neutral	0.64	neutral	2.72	20.90	deleterious	0.45432647	0.85	0.5	neutral	0.09	neutral	0.44	neutral	0.17	neutral	7	0.98	deleterious	0.09	neutral	-2	neutral	0.66	deleterious	-2.07	low_impact	-0.15	medium_impact	0.07	medium_impact	0.49	0.85	NA	NA	0.61	P	0.51	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11681	11681	A	C	MI.18260	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	922	308	S	R	Agc/Cgc	2.1	1	0	probably_damaging	1	deleterious	0.02	neutral	4.47	neutral	-2.05	deleterious	-4.05	high_impact	3.86	0.63	neutral	0.06	damaging	4.00	23.60	deleterious	0.04	0.35	0.88	disease	0.93	disease	0.74	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-0.75	medium_impact	2.69	high_impact	0.49	0.8	44.66	8.21	0.51	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11681	11681	A	G	MI.18261	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	922	308	S	G	Agc/Ggc	2.1	1	0	probably_damaging	1	neutral	1	neutral	4.71	neutral	1.5	neutral	-1.39	neutral_impact	0.14	0.74	neutral	0.51	neutral	1.49	13.24	neutral	0.17	0.45	0.82	disease	0.15	neutral	0.31	neutral	0.36	neutral	3	1	deleterious	0.5	deleterious	-2	neutral	0.71	deleterious	-3.54	low_impact	1.88	high_impact	-0.99	medium_impact	0.50	0.8	44.66	8.21	0.41	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11682	11682	G	A	MI.18262	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	923	308	S	N	aGc/aAc	1.64	1	0	probably_damaging	1	deleterious	0	neutral	4.58	neutral	-1.94	neutral	-2.14	high_impact	3.86	0.67	neutral	0.08	damaging	3.69	23.30	deleterious	0.44	0.55	0.8	disease	0.8	disease	0.6	disease	0.71	disease	4	1	deleterious	0	deleterious	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.69	high_impact	0.41	0.8	44.66	8.21	0.47	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11682	11682	G	C	MI.18263	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	923	308	S	T	aGc/aCc	1.64	1	0	probably_damaging	1	deleterious	0.02	neutral	4.47	neutral	-1.58	deleterious	-2.62	medium_impact	2.89	0.71	neutral	0.1	damaging	3.44	23.00	deleterious	0.23	0.45	0.44	neutral	0.67	disease	0.4	neutral	0.46	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.74	deleterious	-3.54	low_impact	-0.75	medium_impact	1.73	medium_impact	0.66	0.8	44.66	8.21	0.46	N	0.73	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11682	11682	G	T	MI.18264	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	923	308	S	I	aGc/aTc	1.64	1	0	probably_damaging	1	deleterious	0	neutral	4.43	neutral	-2.48	deleterious	-5.24	high_impact	3.52	0.69	neutral	0.08	damaging	4.18	23.80	deleterious	0.04	0.35	0.45	neutral	0.92	disease	0.62	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	2.36	high_impact	0.31	0.8	44.66	8.21	0.44	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11684	11684	T	A	MI.18265	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	925	309	F	I	Ttc/Atc	-6.88	0	0	possibly_damaging	0.63	neutral	0.26	neutral	4.83	neutral	0.6	deleterious	-4.14	neutral_impact	0.45	0.74	neutral	0.77	neutral	4.51	24.30	deleterious	0.15	0.4	0.43	neutral	0.73	disease	0.31	neutral	0.38	neutral	2	0.76	neutral	0.32	neutral	-3	neutral	0.71	deleterious	-0.94	medium_impact	-0.05	medium_impact	-0.68	medium_impact	0.62	0.8	22	22.88	0.39	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11684	11684	T	C	MI.18266	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	925	309	F	L	Ttc/Ctc	-6.88	0	0	benign	0.08	neutral	0.81	neutral	4.8	neutral	1.09	deleterious	-3.96	neutral_impact	-0.38	0.7	neutral	0.79	neutral	2.93	22.00	deleterious	0.22	0.45	0.44	neutral	0.47	neutral	0.33	neutral	0.46	neutral	1	0.09	neutral	0.87	deleterious	-6	neutral	0.67	deleterious	0.28	medium_impact	0.56	medium_impact	-1.5	low_impact	0.75	0.85	22	22.88	0.25	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	COSM6716718	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11684	11684	T	G	MI.18267	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	925	309	F	V	Ttc/Gtc	-6.88	0	0	possibly_damaging	0.74	neutral	0.22	neutral	4.75	neutral	0.48	deleterious	-4.83	neutral_impact	0.71	0.76	neutral	0.62	neutral	4.21	23.90	deleterious	0.12	0.4	0.53	disease	0.82	disease	0.48	neutral	0.4	neutral	2	0.84	neutral	0.24	neutral	-3	neutral	0.73	deleterious	-1.14	low_impact	-0.11	medium_impact	-0.42	medium_impact	0.39	0.8	22	22.88	0.31	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11685	11685	T	C	MI.18268	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	926	309	F	S	tTc/tCc	1.64	0.01	0	probably_damaging	0.96	neutral	0.13	neutral	4.69	neutral	-1.61	deleterious	-6.05	low_impact	1.67	0.74	neutral	0.59	neutral	4.29	24.00	deleterious	0.05	0.35	0.41	neutral	0.81	disease	0.52	disease	0.64	disease	3	0.98	neutral	0.09	neutral	-2	neutral	0.74	deleterious	-2.01	low_impact	-0.26	medium_impact	0.53	medium_impact	0.25	0.8	22	22.88	0.39	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11685	11685	T	G	MI.18269	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	926	309	F	C	tTc/tGc	1.64	0.01	0	probably_damaging	0.98	neutral	0.11	neutral	4.59	deleterious	-3.43	deleterious	-5.97	medium_impact	2.27	0.74	neutral	0.69	neutral	4.20	23.90	deleterious	0.05	0.35	0.75	disease	0.85	disease	0.53	disease	0.6	disease	2	0.99	deleterious	0.07	neutral	1	deleterious	0.77	deleterious	-2.31	low_impact	-0.31	medium_impact	1.12	medium_impact	0.26	0.8	22	22.88	0.36	N	0.95	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8546	8546	C	A	MI.1827	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	181	61	L	I	Ctt/Att	-0.33	0	0	possibly_damaging	0.9	neutral	0.19	neutral	1.86	neutral	-1.63	neutral	-0.33	low_impact	1.36	1	neutral	0.53	neutral	2.46	19.23	deleterious	0.45432647	0.85	0.33	neutral	0.07	neutral	0.41	neutral	0.16	neutral	7	0.94	neutral	0.15	neutral	-3	neutral	0.62	deleterious	-1.66	low_impact	-0.06	medium_impact	0.07	medium_impact	0.60	0.85	NA	NA	0.61	P	0.48	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11685	11685	T	A	MI.18270	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	926	309	F	Y	tTc/tAc	1.64	0.01	0	possibly_damaging	0.89	neutral	0.53	neutral	4.63	neutral	0.56	neutral	-1.18	neutral_impact	0.63	0.75	neutral	0.99	neutral	3.10	22.50	deleterious	0.18	0.45	0.58	disease	0.6	disease	0.34	neutral	0.38	neutral	2	0.87	neutral	0.32	neutral	-3	neutral	0.72	deleterious	-1.57	low_impact	0.23	medium_impact	-0.5	medium_impact	0.69	0.85	22	22.88	0.41	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11686	11686	C	A	MI.18271	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	927	309	F	L	ttC/ttA	0.49	0	0	benign	0.08	neutral	0.81	neutral	4.8	neutral	1.09	deleterious	-3.96	neutral_impact	-0.38	0.7	neutral	0.79	neutral	3.45	23.00	deleterious	0.22	0.45	0.44	neutral	0.47	neutral	0.33	neutral	0.46	neutral	1	0.09	neutral	0.87	deleterious	-6	neutral	0.67	deleterious	0.28	medium_impact	0.56	medium_impact	-1.5	low_impact	0.75	0.85	22	22.88	0.26	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11686	11686	C	G	MI.18272	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	927	309	F	L	ttC/ttG	0.49	0	0	benign	0.08	neutral	0.81	neutral	4.8	neutral	1.09	deleterious	-3.96	neutral_impact	-0.38	0.7	neutral	0.79	neutral	3.14	22.60	deleterious	0.22	0.45	0.44	neutral	0.47	neutral	0.33	neutral	0.46	neutral	1	0.09	neutral	0.87	deleterious	-6	neutral	0.67	deleterious	0.28	medium_impact	0.56	medium_impact	-1.5	low_impact	0.75	0.85	22	22.88	0.26	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11687	11687	A	C	MI.18273	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	928	310	T	P	Acc/Ccc	-4.12	0	0	possibly_damaging	0.72	neutral	0.1	neutral	4.56	neutral	-2.23	neutral	-2.48	medium_impact	2.8	0.66	neutral	0.52	neutral	3.25	22.80	deleterious	0.05	0.35	0.72	disease	0.9	disease	0.72	disease	0.73	disease	5	0.92	neutral	0.19	neutral	0	NA	0.73	deleterious	-1.1	low_impact	-0.33	medium_impact	1.64	medium_impact	0.34	0.8	24.18	34.28	0.33	N	0.75	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11687	11687	A	G	MI.18274	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	928	310	T	A	Acc/Gcc	-4.12	0	0	benign	0.02	neutral	0.34	neutral	4.64	neutral	-0.08	neutral	-1.1	low_impact	1.24	0.75	neutral	0.88	neutral	0.40	6.59	deleterious	0.15	0.4	0.41	neutral	0.5	neutral	0.37	neutral	0.37	neutral	3	0.64	neutral	0.66	deleterious	-6	neutral	0.16	neutral	0.87	medium_impact	0.04	medium_impact	0.1	medium_impact	0.39	0.8	24.18	34.28	0.43	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11687	11687	A	T	MI.18275	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	928	310	T	S	Acc/Tcc	-4.12	0	0	benign	0.04	neutral	0.87	neutral	4.67	neutral	0.37	neutral	-0.84	neutral_impact	0.46	0.68	neutral	0.77	neutral	0.09	3.54	deleterious	0.23	0.45	0.52	disease	0.29	neutral	0.31	neutral	0.38	neutral	2	0.06	neutral	0.92	deleterious	-6	neutral	0.32	neutral	0.58	medium_impact	0.67	medium_impact	-0.67	medium_impact	0.67	0.85	24.18	34.28	0.27	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11688	11688	C	G	MI.18276	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	929	310	T	S	aCc/aGc	3.02	0.96	0	benign	0.04	neutral	0.87	neutral	4.67	neutral	0.37	neutral	-0.84	neutral_impact	0.46	0.68	neutral	0.77	neutral	0.31	5.83	deleterious	0.23	0.45	0.52	disease	0.29	neutral	0.31	neutral	0.38	neutral	2	0.06	neutral	0.92	deleterious	-6	neutral	0.32	neutral	0.58	medium_impact	0.67	medium_impact	-0.67	medium_impact	0.67	0.85	24.18	34.28	0.36	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11688	11688	C	A	MI.18277	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	929	310	T	N	aCc/aAc	3.02	0.96	0	possibly_damaging	0.57	neutral	0.64	neutral	4.63	neutral	-0.21	neutral	-2.12	low_impact	1.25	0.68	neutral	0.61	neutral	3.40	23.00	deleterious	0.23	0.45	0.51	disease	0.73	disease	0.37	neutral	0.4	neutral	2	0.5	neutral	0.54	deleterious	-3	neutral	0.59	deleterious	-0.83	medium_impact	0.34	medium_impact	0.11	medium_impact	0.59	0.8	24.18	34.28	0.37	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11688	11688	C	T	MI.18278	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	929	310	T	I	aCc/aTc	3.02	0.96	0	possibly_damaging	0.57	neutral	0.29	neutral	4.65	neutral	0.11	neutral	-1.04	low_impact	1.77	0.73	neutral	0.53	neutral	2.37	18.62	deleterious	0.1	0.4	0.79	disease	0.84	disease	0.56	disease	0.66	disease	3	0.71	neutral	0.36	neutral	-3	neutral	0.58	deleterious	-0.83	medium_impact	-0.02	medium_impact	0.63	medium_impact	0.63	0.8	24.18	34.28	0.44	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11690	11690	G	A	MI.18279	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	931	311	G	S	Ggc/Agc	-0.2	0.54	0	probably_damaging	1	neutral	0.13	neutral	4.59	neutral	-2.95	deleterious	-5.71	medium_impact	1.95	0.55	damaging	0.35	neutral	4.24	23.90	deleterious	0.05	0.35	0.39	neutral	0.85	disease	0.63	disease	0.61	disease	2	1	deleterious	0.07	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.26	medium_impact	0.8	medium_impact	0.71	0.85	46.41	9.01	0.32	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8546	8546	C	G	MI.1828	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	181	61	L	V	Ctt/Gtt	-0.33	0	0	possibly_damaging	0.9	neutral	0.32	neutral	1.87	neutral	-1.37	neutral	0.25	low_impact	1.36	1	neutral	0.67	neutral	1.63	14.00	neutral	0.51274914	0.85	0.31	neutral	0.08	neutral	0.43	neutral	0.17	neutral	7	0.91	neutral	0.21	neutral	-3	neutral	0.61	deleterious	-1.66	low_impact	0.11	medium_impact	0.07	medium_impact	0.49	0.85	NA	NA	0.6	P	0.40	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11690	11690	G	T	MI.18280	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	931	311	G	C	Ggc/Tgc	-0.2	0.54	0	probably_damaging	1	deleterious	0.01	neutral	4.51	deleterious	-6.12	deleterious	-8.58	high_impact	3.78	0.59	damaging	0.22	damaging	4.22	23.90	deleterious	0.02	0.35	0.91	disease	0.92	disease	0.7	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-0.92	medium_impact	2.61	high_impact	0.20	0.8	46.41	9.01	0.4	N	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11690	11690	G	C	MI.18281	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	931	311	G	R	Ggc/Cgc	-0.2	0.54	0	probably_damaging	1	deleterious	0	neutral	4.5	deleterious	-4.41	deleterious	-7.62	high_impact	4.47	0.6	neutral	0.22	damaging	4.03	23.70	deleterious	0.02	0.35	0.68	disease	0.93	disease	0.81	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.3	high_impact	0.40	0.8	46.41	9.01	0.56	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11691	11691	G	C	MI.18282	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	932	311	G	A	gGc/gCc	6.01	1	0	probably_damaging	1	neutral	0.09	neutral	4.71	neutral	-0.42	deleterious	-5.71	medium_impact	2.64	0.58	damaging	0.43	neutral	3.22	22.70	deleterious	0.1	0.4	0.57	disease	0.76	disease	0.6	disease	0.57	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.36	medium_impact	1.49	medium_impact	0.40	0.8	46.41	9.01	0.59	P	0.76	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11691	11691	G	A	MI.18283	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	932	311	G	D	gGc/gAc	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.49	deleterious	-4.89	deleterious	-6.66	high_impact	4.47	0.65	neutral	0.25	damaging	3.89	23.50	deleterious	0.02	0.35	0.5	disease	0.91	disease	0.8	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.3	high_impact	0.17	0.8	46.41	9.01	0.64	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11691	11691	G	T	MI.18284	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	932	311	G	V	gGc/gTc	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.61	neutral	-2.87	deleterious	-8.57	high_impact	3.78	0.58	damaging	0.28	damaging	3.89	23.50	deleterious	0.02	0.35	0.66	disease	0.92	disease	0.71	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	2.61	high_impact	0.24	0.8	46.41	9.01	0.61	P	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11693	11693	G	A	MI.18285	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	934	312	A	T	Gca/Aca	-9.87	0	0	probably_damaging	1	deleterious	0.02	neutral	4.26	deleterious	-4.01	deleterious	-3.78	medium_impact	2.38	0.68	neutral	0.14	damaging	4.30	24.00	deleterious	0.05	0.35	0.65	disease	0.82	disease	0.58	disease	0.58	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.54	low_impact	-0.75	medium_impact	1.23	medium_impact	0.69	0.85	47.28	9.46	0.3	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	COSM6188328	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11693	11693	G	C	MI.18286	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	934	312	A	P	Gca/Cca	-9.87	0	0	probably_damaging	1	deleterious	0	neutral	4.18	deleterious	-6.41	deleterious	-4.75	high_impact	4.32	0.65	neutral	0.12	damaging	3.95	23.60	deleterious	0.02	0.35	0.84	disease	0.91	disease	0.76	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.15	high_impact	0.49	0.8	47.28	9.46	0.41	N	0.96	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11693	11693	G	T	MI.18287	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	934	312	A	S	Gca/Tca	-9.87	0	0	probably_damaging	1	neutral	0.5	neutral	4.33	deleterious	-3.08	deleterious	-2.84	low_impact	1.74	0.68	neutral	0.22	damaging	3.82	23.40	deleterious	0.11	0.4	0.57	disease	0.65	disease	0.46	neutral	0.36	neutral	3	1	deleterious	0.25	neutral	-2	neutral	0.79	deleterious	-3.54	low_impact	0.2	medium_impact	0.6	medium_impact	0.52	0.8	47.28	9.46	0.24	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11694	11694	C	G	MI.18288	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	935	312	A	G	gCa/gGa	5.09	1	0	probably_damaging	1	neutral	0.17	neutral	4.3	neutral	-2.34	deleterious	-3.8	medium_impact	2.35	0.73	neutral	0.18	damaging	4.04	23.70	deleterious	0.08	0.35	0.62	disease	0.78	disease	0.64	disease	0.59	disease	2	1	deleterious	0.09	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.18	medium_impact	1.2	medium_impact	0.57	0.8	47.28	9.46	0.57	P	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11694	11694	C	T	MI.18289	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	935	312	A	V	gCa/gTa	5.09	1	0	probably_damaging	1	deleterious	0.01	neutral	4.25	deleterious	-3.1	deleterious	-3.79	medium_impact	3	0.7	neutral	0.13	damaging	4.56	24.40	deleterious	0.04	0.35	0.36	neutral	0.88	disease	0.65	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	1.84	medium_impact	0.68	0.85	47.28	9.46	0.53	P	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8547	8547	T	G	MI.1829	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	182	61	L	R	cTt/cGt	6.38	0.95	0	probably_damaging	0.98	neutral	0.49	neutral	1.83	neutral	-2.15	neutral	-0.18	low_impact	1.36	1	neutral	0.48	neutral	3.07	22.40	deleterious	0.36427644	0.85	0.51	disease	0.31	neutral	0.54	disease	0.18	neutral	6	0.98	deleterious	0.26	neutral	-2	neutral	0.70	deleterious	-2.36	low_impact	0.28	medium_impact	0.07	medium_impact	0.50	0.85	NA	NA	0.63	P	0.54	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11694	11694	C	A	MI.18290	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	935	312	A	E	gCa/gAa	5.09	1	0	probably_damaging	1	deleterious	0	neutral	4.21	deleterious	-5.64	deleterious	-4.74	high_impact	4.32	0.67	neutral	0.13	damaging	4.57	24.40	deleterious	0.02	0.35	0.87	disease	0.92	disease	0.75	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.15	high_impact	0.27	0.8	47.28	9.46	0.6	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11696	11696	G	A	MI.18291	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	937	313	V	I	Gtc/Atc	-11.25	0	0.03	benign	0.01	neutral	0.7	neutral	4.76	neutral	0.15	neutral	-0.32	neutral_impact	-0.58	0.28	damaging	0.34	neutral	-0.96	0.02	neutral	0.28	0.45	0.33	neutral	0.09	neutral	0.3	neutral	0.26	neutral	5	0.29	neutral	0.85	deleterious	-6	neutral	0.12	neutral	1.16	medium_impact	0.41	medium_impact	-1.7	low_impact	0.83	0.9	25.05	23.74	0.82	P	0.78	disease_causing_automatic	0	0.01	rs200873900	Pathogenic	Leber's_optic_atrophy|Leber_hereditary_optic_neuropathy_with_dystonia	24749	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:C1839040,OMIM:500001	.	.	.	.	G11696A	LHON / LDYT / DEAF / hypertension helper mut.	+	+	Reported - possibly synergistic	12	P	N	P,N	neutral
chrM	11696	11696	G	C	MI.18292	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	937	313	V	L	Gtc/Ctc	-11.25	0	0.03	benign	0.05	neutral	1	neutral	4.75	neutral	0.69	neutral	-0.54	neutral_impact	-0.44	0.7	neutral	0.91	neutral	-0.81	0.04	neutral	0.15	0.4	0.4	neutral	0.17	neutral	0.26	neutral	0.26	neutral	5	0.05	neutral	0.98	deleterious	-6	neutral	0.15	neutral	0.48	medium_impact	1.88	high_impact	-1.56	low_impact	0.53	0.8	25.05	23.74	0.33	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11696	11696	G	T	MI.18293	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	937	313	V	F	Gtc/Ttc	-11.25	0	0.03	benign	0.38	neutral	0.11	neutral	4.66	neutral	-1.98	neutral	-1.91	neutral_impact	0.13	0.73	neutral	0.59	neutral	0.96	10.43	neutral	0.04	0.35	0.4	neutral	0.64	disease	0.37	neutral	0.4	neutral	2	0.87	neutral	0.37	neutral	-6	neutral	0.29	neutral	-0.52	medium_impact	-0.31	medium_impact	-1	medium_impact	0.28	0.8	25.05	23.74	0.44	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11697	11697	T	A	MI.18294	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	938	313	V	D	gTc/gAc	0.95	0.01	0	possibly_damaging	0.47	deleterious	0.01	neutral	4.53	deleterious	-5.37	neutral	-2.32	medium_impact	2.18	0.75	neutral	0.51	neutral	2.88	21.70	deleterious	0.02	0.35	0.88	disease	0.69	disease	0.66	disease	0.73	disease	5	0.99	deleterious	0.27	neutral	4	deleterious	0.40	neutral	-0.67	medium_impact	-0.92	medium_impact	1.03	medium_impact	0.22	0.8	25.05	23.74	0.34	N	0.30	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11697	11697	T	C	MI.18295	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	938	313	V	A	gTc/gCc	0.95	0.01	0	benign	0.18	deleterious	0.02	neutral	4.61	neutral	-1.69	neutral	-0.95	low_impact	1.63	0.77	neutral	0.75	neutral	0.57	7.96	deleterious	0.07	0.35	0.34	neutral	0.28	neutral	0.52	disease	0.47	neutral	1	0.98	neutral	0.42	neutral	-2	neutral	0.17	neutral	-0.1	medium_impact	-0.75	medium_impact	0.49	medium_impact	0.17	0.8	25.05	23.74	0.47	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11697	11697	T	G	MI.18296	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	938	313	V	G	gTc/gGc	0.95	0.01	0	benign	0.26	deleterious	0.04	neutral	4.56	deleterious	-3.34	deleterious	-3.04	low_impact	1.83	0.75	neutral	0.55	neutral	2.06	16.58	deleterious	0.03	0.35	0.5	neutral	0.47	neutral	0.55	disease	0.51	disease	0	0.95	neutral	0.39	neutral	-2	neutral	0.27	neutral	-0.29	medium_impact	-0.57	medium_impact	0.68	medium_impact	0.30	0.8	25.05	23.74	0.42	N	0.42	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11699	11699	A	C	MI.18297	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	940	314	I	L	Att/Ctt	-6.42	0	0	benign	0.04	neutral	0.49	neutral	4.6	neutral	1.8	neutral	-0.54	neutral_impact	0.24	0.72	neutral	0.73	neutral	0.85	9.79	deleterious	0.16	0.45	0.57	disease	0.48	neutral	0.39	neutral	0.54	disease	1	0.47	neutral	0.73	deleterious	-6	neutral	0.13	neutral	0.58	medium_impact	0.19	medium_impact	-0.89	medium_impact	0.56	0.8	30.72	30.75	0.36	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11699	11699	A	G	MI.18298	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	940	314	I	V	Att/Gtt	-6.42	0	0	benign	0	neutral	0.35	neutral	4.44	neutral	0.54	neutral	0.39	neutral_impact	0.65	0.78	neutral	0.96	neutral	-0.61	0.12	neutral	0.24	0.45	0.57	disease	0.19	neutral	0.38	neutral	0.46	neutral	1	0.65	neutral	0.68	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.05	medium_impact	-0.48	medium_impact	0.50	0.8	30.72	30.75	0.38	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11699	11699	A	T	MI.18299	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	940	314	I	F	Att/Ttt	-6.42	0	0	benign	0.29	neutral	0.22	neutral	4.51	neutral	2.39	neutral	-1.84	low_impact	1.38	0.69	neutral	0.52	neutral	1.92	15.69	deleterious	0.12	0.4	0.42	neutral	0.7	disease	0.62	disease	0.63	disease	3	0.74	neutral	0.47	neutral	-6	neutral	0.18	neutral	-0.35	medium_impact	-0.11	medium_impact	0.24	medium_impact	0.56	0.8	30.72	30.75	0.35	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8612	8612	T	G	MI.183	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	86	29	L	R	cTa/cGa	-2.42	0	0	probably_damaging	1	deleterious	0.01	neutral	4.3	neutral	-2.99	deleterious	-4.47	medium_impact	3.19	0.78	neutral	0.14	damaging	3.98	23.60	deleterious	0.24	0.65	0.75	disease	0.79	disease	0.68	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	1.64	medium_impact	0.55	0.9	17.26	17.02	0.27	N	0.88	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8547	8547	T	C	MI.1830	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	182	61	L	P	cTt/cCt	6.38	0.95	0	probably_damaging	0.98	neutral	0.53	neutral	2.28	neutral	0.65	neutral	6.22	neutral_impact	-2.04	0.99	neutral	0.92	neutral	2.51	19.51	deleterious	0.34743468	0.85	0.12	neutral	0.03	neutral	0.2	neutral	0.06	neutral	9	0.98	deleterious	0.28	neutral	-2	neutral	0.61	deleterious	-2.36	low_impact	0.32	medium_impact	-2.85	low_impact	0.50	0.85	NA	NA	0.5	N	0.07	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11700	11700	T	G	MI.18300	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	941	314	I	S	aTt/aGt	-0.43	0	0	benign	0.1	neutral	0.08	neutral	4.36	neutral	-1.47	neutral	-0.53	low_impact	1.76	0.74	neutral	0.65	neutral	2.38	18.68	deleterious	0.03	0.35	0.73	disease	0.74	disease	0.58	disease	0.63	disease	3	0.91	neutral	0.49	deleterious	-6	neutral	0.23	neutral	0.18	medium_impact	-0.39	medium_impact	0.62	medium_impact	0.28	0.8	30.72	30.75	0.38	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11700	11700	T	A	MI.18301	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	941	314	I	N	aTt/aAt	-0.43	0	0	benign	0.32	deleterious	0.01	neutral	4.33	deleterious	-3.03	neutral	-2.23	medium_impact	2.89	0.67	neutral	0.49	neutral	2.57	19.90	deleterious	0.07	0.35	0.88	disease	0.77	disease	0.59	disease	0.73	disease	5	0.99	deleterious	0.35	neutral	1	deleterious	0.27	neutral	-0.41	medium_impact	-0.92	medium_impact	1.73	medium_impact	0.33	0.8	30.72	30.75	0.32	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11700	11700	T	C	MI.18302	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	941	314	I	T	aTt/aCt	-0.43	0	0	benign	0	neutral	0.24	neutral	4.37	neutral	-0.91	neutral	0.39	low_impact	0.92	0.74	neutral	0.95	neutral	-0.10	1.71	neutral	0.07	0.35	0.63	disease	0.33	neutral	0.4	neutral	0.6	disease	2	0.76	neutral	0.62	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	-0.08	medium_impact	-0.22	medium_impact	0.28	0.8	30.72	30.75	0.5	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11701	11701	T	A	MI.18303	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	942	314	I	M	atT/atA	0.72	0	0.01	possibly_damaging	0.56	neutral	0.18	neutral	4.41	neutral	-0.5	neutral	-0.69	neutral_impact	0.44	0.76	neutral	0.96	neutral	0.92	10.20	neutral	0.15	0.4	0.4	neutral	0.35	neutral	0.4	neutral	0.46	neutral	1	0.81	neutral	0.31	neutral	-3	neutral	0.20	neutral	-0.82	medium_impact	-0.17	medium_impact	-0.69	medium_impact	0.52	0.8	30.72	30.75	0.44	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11701	11701	T	G	MI.18304	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	942	314	I	M	atT/atG	0.72	0	0.01	possibly_damaging	0.56	neutral	0.18	neutral	4.41	neutral	-0.5	neutral	-0.69	neutral_impact	0.44	0.76	neutral	0.96	neutral	0.57	7.96	deleterious	0.15	0.4	0.4	neutral	0.35	neutral	0.4	neutral	0.46	neutral	1	0.81	neutral	0.31	neutral	-3	neutral	0.20	neutral	-0.82	medium_impact	-0.17	medium_impact	-0.69	medium_impact	0.52	0.8	30.72	30.75	0.45	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11702	11702	C	T	MI.18305	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	943	315	L	F	Ctc/Ttc	-2.96	0	0	probably_damaging	1	deleterious	0.02	neutral	4.52	neutral	-1.57	deleterious	-3.75	medium_impact	3.22	0.49	damaging	0.07	damaging	4.08	23.70	deleterious	0.2	0.45	0.8	disease	0.71	disease	0.69	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-0.75	medium_impact	2.06	high_impact	0.44	0.8	45.1	8.68	0.31	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11702	11702	C	G	MI.18306	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	943	315	L	V	Ctc/Gtc	-2.96	0	0	probably_damaging	1	neutral	0.08	neutral	4.53	neutral	-1.07	deleterious	-2.8	medium_impact	2.74	0.49	damaging	0.08	damaging	3.52	23.10	deleterious	0.22	0.45	0.73	disease	0.56	disease	0.64	disease	0.53	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.39	medium_impact	1.59	medium_impact	0.55	0.8	45.1	8.68	0.33	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11702	11702	C	A	MI.18307	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	943	315	L	I	Ctc/Atc	-2.96	0	0	probably_damaging	1	deleterious	0.03	neutral	4.59	neutral	-1.34	neutral	-1.88	medium_impact	2.52	0.56	damaging	0.09	damaging	4.16	23.80	deleterious	0.22	0.45	0.59	disease	0.65	disease	0.62	disease	0.58	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-3.54	low_impact	-0.64	medium_impact	1.37	medium_impact	0.47	0.8	45.1	8.68	0.29	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11703	11703	T	G	MI.18308	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	944	315	L	R	cTc/cGc	-1.58	0	0	probably_damaging	1	deleterious	0	neutral	4.46	neutral	-2.88	deleterious	-5.63	high_impact	4.26	0.54	damaging	0.06	damaging	4.25	23.90	deleterious	0.02	0.35	0.95	disease	0.86	disease	0.79	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.09	high_impact	0.22	0.8	45.1	8.68	0.43	N	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11703	11703	T	A	MI.18309	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	944	315	L	H	cTc/cAc	-1.58	0	0	probably_damaging	1	deleterious	0	neutral	4.64	neutral	1.9	deleterious	-6.58	high_impact	4.26	0.5	damaging	0.06	damaging	4.13	23.80	deleterious	0.05	0.35	0.96	disease	0.79	disease	0.75	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.09	high_impact	0.24	0.8	45.1	8.68	0.4	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8547	8547	T	A	MI.1831	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	182	61	L	H	cTt/cAt	6.38	0.95	0	probably_damaging	0.99	neutral	0.14	neutral	1.81	deleterious	-3.32	neutral	-0.32	low_impact	1.36	0.99	neutral	0.52	neutral	4.08	23.70	deleterious	0.29361508	0.85	0.66	disease	0.24	neutral	0.49	neutral	0.18	neutral	6	0.99	deleterious	0.08	neutral	-2	neutral	0.70	deleterious	-2.65	low_impact	-0.15	medium_impact	0.07	medium_impact	0.50	0.85	NA	NA	0.69	P	0.45	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11703	11703	T	C	MI.18310	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	944	315	L	P	cTc/cCc	-1.58	0	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-3.69	deleterious	-6.58	high_impact	3.71	0.51	damaging	0.07	damaging	4.00	23.60	deleterious	0.02	0.35	0.93	disease	0.79	disease	0.78	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.54	high_impact	0.32	0.8	45.1	8.68	0.38	N	0.98	polymorphism	1	0.18	.	.	.	.	.	pancreatic cancer cell line	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11705	11705	A	G	MI.18311	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	946	316	M	V	Ata/Gta	-3.42	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.56	neutral	-0.93	deleterious	-3.82	high_impact	3.6	0.51	damaging	0.07	damaging	2.83	21.50	deleterious	0.12	0.4	0.47	neutral	0.84	disease	0.72	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.67	deleterious	-2.59	low_impact	-0.92	medium_impact	2.44	high_impact	0.43	0.8	46.19	9.29	0.32	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11705	11705	A	C	MI.18312	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	946	316	M	L	Ata/Cta	-3.42	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.86	neutral	0.91	deleterious	-2.87	medium_impact	3.05	0.52	damaging	0.05	damaging	3.34	22.90	deleterious	0.13	0.4	0.56	disease	0.83	disease	0.67	disease	0.69	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.60	deleterious	-2.31	low_impact	-0.92	medium_impact	1.89	medium_impact	0.40	0.8	46.19	9.29	0.3	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11705	11705	A	T	MI.18313	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	946	316	M	L	Ata/Tta	-3.42	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.86	neutral	0.91	deleterious	-2.87	medium_impact	3.05	0.52	damaging	0.05	damaging	3.44	23.00	deleterious	0.13	0.4	0.56	disease	0.83	disease	0.67	disease	0.69	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.60	deleterious	-2.31	low_impact	-0.92	medium_impact	1.89	medium_impact	0.40	0.8	46.19	9.29	0.3	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11706	11706	T	A	MI.18314	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	947	316	M	K	aTa/aAa	6.93	1	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-4.27	deleterious	-5.73	high_impact	4.57	0.52	damaging	0.06	damaging	4.06	23.70	deleterious	0.02	0.35	0.85	disease	0.9	disease	0.78	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.4	high_impact	0.23	0.8	46.19	9.29	0.66	P	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11706	11706	T	C	MI.18315	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	947	316	M	T	aTa/aCa	6.93	1	0	probably_damaging	1	deleterious	0	neutral	4.51	neutral	-2.11	deleterious	-5.73	high_impact	4.22	0.56	damaging	0.09	damaging	3.06	22.40	deleterious	0.04	0.35	0.53	disease	0.85	disease	0.72	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	3.05	high_impact	0.24	0.8	46.19	9.29	0.59	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11707	11707	A	C	MI.18316	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	948	316	M	I	atA/atC	7.4	1	0	probably_damaging	0.99	deleterious	0.02	neutral	4.58	neutral	-0.54	deleterious	-3.82	high_impact	3.67	0.55	damaging	0.07	damaging	3.52	23.10	deleterious	0.13	0.4	0.37	neutral	0.87	disease	0.7	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.59	low_impact	-0.75	medium_impact	2.51	high_impact	0.52	0.8	46.19	9.29	0.59	P	0.95	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11707	11707	A	T	MI.18317	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	948	316	M	I	atA/atT	7.4	1	0	probably_damaging	0.99	deleterious	0.02	neutral	4.58	neutral	-0.54	deleterious	-3.82	high_impact	3.67	0.55	damaging	0.07	damaging	3.58	23.20	deleterious	0.13	0.4	0.37	neutral	0.87	disease	0.7	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.59	low_impact	-0.75	medium_impact	2.51	high_impact	0.52	0.8	46.19	9.29	0.6	P	0.95	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11708	11708	A	C	MI.18318	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	949	317	I	L	Atc/Ctc	2.79	1	0	benign	0.12	neutral	0.38	neutral	4.57	neutral	0.28	neutral	-1.74	low_impact	1.76	0.68	neutral	0.53	neutral	2.00	16.19	deleterious	0.2	0.45	0.49	neutral	0.64	disease	0.55	disease	0.41	neutral	2	0.56	neutral	0.63	deleterious	-6	neutral	0.22	neutral	0.1	medium_impact	0.08	medium_impact	0.62	medium_impact	0.56	0.8	40.09	8.05	0.55	P	0.86	polymorphism	1	0.03	rs386829138	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11708	11708	A	G	MI.18319	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	949	317	I	V	Atc/Gtc	2.79	1	0	benign	0.03	neutral	0.18	neutral	4.4	neutral	-0.06	neutral	-0.86	low_impact	1.02	0.81	neutral	0.88	neutral	0.13	3.95	deleterious	0.27	0.45	0.54	disease	0.26	neutral	0.49	neutral	0.36	neutral	3	0.81	neutral	0.58	deleterious	-6	neutral	0.15	neutral	0.7	medium_impact	-0.17	medium_impact	-0.12	medium_impact	0.40	0.8	40.09	8.05	0.5	P	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8549	8549	C	A	MI.1832	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	184	62	H	N	Cat/Aat	2.9	1	0	possibly_damaging	0.85	neutral	0.24	neutral	1.86	neutral	-2.44	neutral	-2.06	medium_impact	2.21	0.97	neutral	0.3	neutral	4.77	24.70	deleterious	0.86306208	0.90	0.52	disease	0.17	neutral	0.62	disease	0.13	neutral	8	0.89	neutral	0.2	neutral	0	NA	0.56	deleterious	-1.47	low_impact	0.01	medium_impact	0.8	medium_impact	0.67	0.85	NA	NA	0.6	P	0.62	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11708	11708	A	T	MI.18320	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	949	317	I	F	Atc/Ttc	2.79	1	0	possibly_damaging	0.75	neutral	0.06	neutral	4.35	neutral	-0.87	deleterious	-3.72	medium_impact	2.54	0.67	neutral	0.48	neutral	2.09	16.80	deleterious	0.11	0.4	0.71	disease	0.82	disease	0.63	disease	0.66	disease	3	0.95	neutral	0.16	neutral	0	NA	0.64	deleterious	-1.17	low_impact	-0.47	medium_impact	1.39	medium_impact	0.58	0.8	40.09	8.05	0.58	P	0.96	polymorphism	1	0.08	rs386829138	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11709	11709	T	C	MI.18321	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	950	317	I	T	aTc/aCc	3.25	1	0	possibly_damaging	0.66	deleterious	0.01	neutral	4.34	neutral	-2.4	deleterious	-4.59	medium_impact	3.28	0.65	neutral	0.51	neutral	1.71	14.45	neutral	0.04	0.35	0.4	neutral	0.71	disease	0.59	disease	0.63	disease	3	0.99	deleterious	0.18	neutral	4	deleterious	0.43	neutral	-0.99	medium_impact	-0.92	medium_impact	2.12	high_impact	0.23	0.8	40.09	8.05	0.48	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11709	11709	T	G	MI.18322	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	950	317	I	S	aTc/aGc	3.25	1	0	possibly_damaging	0.79	deleterious	0	neutral	4.31	deleterious	-3.21	deleterious	-5.57	high_impact	4.17	0.68	neutral	0.53	neutral	2.61	20.30	deleterious	0.02	0.35	0.45	neutral	0.85	disease	0.65	disease	0.71	disease	4	1	deleterious	0.11	neutral	5	deleterious	0.51	deleterious	-1.26	low_impact	-1.48	low_impact	3	high_impact	0.30	0.8	40.09	8.05	0.56	P	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11709	11709	T	A	MI.18323	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	950	317	I	N	aTc/aAc	3.25	1	0	probably_damaging	0.92	deleterious	0	neutral	4.29	deleterious	-4.59	deleterious	-6.53	high_impact	4.17	0.67	neutral	0.49	neutral	3.05	22.40	deleterious	0.04	0.35	0.86	disease	0.83	disease	0.68	disease	0.71	disease	4	1	deleterious	0.04	neutral	6	deleterious	0.74	deleterious	-1.71	low_impact	-1.48	low_impact	3	high_impact	0.41	0.8	40.09	8.05	0.55	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11710	11710	C	A	MI.18324	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	951	317	I	M	atC/atA	5.78	1	0	benign	0.29	deleterious	0.03	neutral	4.36	neutral	-1.52	deleterious	-2.64	medium_impact	2.51	0.74	neutral	0.63	neutral	2.28	18.06	deleterious	0.18	0.45	0.7	disease	0.67	disease	0.61	disease	0.56	disease	1	0.97	neutral	0.37	neutral	1	deleterious	0.60	deleterious	-0.35	medium_impact	-0.64	medium_impact	1.36	medium_impact	0.45	0.8	40.09	8.05	0.51	P	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11710	11710	C	G	MI.18325	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	951	317	I	M	atC/atG	5.78	1	0	benign	0.29	deleterious	0.03	neutral	4.36	neutral	-1.52	deleterious	-2.64	medium_impact	2.51	0.74	neutral	0.63	neutral	1.81	15.02	deleterious	0.18	0.45	0.7	disease	0.67	disease	0.61	disease	0.56	disease	1	0.97	neutral	0.37	neutral	1	deleterious	0.60	deleterious	-0.35	medium_impact	-0.64	medium_impact	1.36	medium_impact	0.45	0.8	40.09	8.05	0.51	P	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11711	11711	G	C	MI.18326	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	952	318	A	P	Gcc/Ccc	-2.73	0	0	probably_damaging	1	deleterious	0	neutral	4.5	deleterious	-4.17	deleterious	-4.6	high_impact	4.33	0.61	neutral	0.33	neutral	3.90	23.50	deleterious	0.02	0.35	0.88	disease	0.92	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.16	high_impact	0.60	0.8	46.19	8.93	0.44	N	0.96	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11711	11711	G	A	MI.18327	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	952	318	A	T	Gcc/Acc	-2.73	0	0	probably_damaging	1	deleterious	0.02	neutral	4.74	neutral	-0.15	deleterious	-3.58	medium_impact	3.17	0.69	neutral	0.51	neutral	4.31	24.00	deleterious	0.11	0.4	0.56	disease	0.8	disease	0.54	disease	0.57	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.75	medium_impact	2.01	high_impact	0.72	0.85	46.19	8.93	0.43	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	COSM1138235	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11711	11711	G	T	MI.18328	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	952	318	A	S	Gcc/Tcc	-2.73	0	0	probably_damaging	1	neutral	0.3	neutral	4.68	neutral	-0.4	deleterious	-2.52	low_impact	1.44	0.67	neutral	0.6	neutral	2.70	20.80	deleterious	0.2	0.45	0.57	disease	0.55	disease	0.4	neutral	0.38	neutral	3	1	deleterious	0.15	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	0	medium_impact	0.3	medium_impact	0.58	0.8	46.19	8.93	0.37	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11712	11712	C	T	MI.18329	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	953	318	A	V	gCc/gTc	4.86	1	0	probably_damaging	1	deleterious	0.02	neutral	4.61	neutral	-1.53	deleterious	-3.74	high_impact	3.77	0.64	neutral	0.44	neutral	4.62	24.50	deleterious	0.06	0.35	0.41	neutral	0.88	disease	0.62	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-0.75	medium_impact	2.6	high_impact	0.76	0.85	46.19	8.93	0.62	P	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8549	8549	C	G	MI.1833	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	184	62	H	D	Cat/Gat	2.9	1	0	possibly_damaging	0.9	neutral	0.16	neutral	1.85	neutral	-2.55	deleterious	-3.11	medium_impact	2.56	0.97	neutral	0.19	damaging	3.89	23.50	deleterious	0.55192990	0.85	0.54	disease	0.2	neutral	0.66	disease	0.15	neutral	7	0.95	neutral	0.13	neutral	0	NA	0.64	deleterious	-1.66	low_impact	-0.12	medium_impact	1.1	medium_impact	0.63	0.85	NA	NA	0.59	P	0.81	polymorphism	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11712	11712	C	A	MI.18330	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	953	318	A	D	gCc/gAc	4.86	1	0	probably_damaging	1	deleterious	0	neutral	4.5	deleterious	-3.64	deleterious	-5.44	high_impact	4.33	0.66	neutral	0.38	neutral	4.64	24.50	deleterious	0.02	0.35	0.92	disease	0.94	disease	0.73	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.16	high_impact	0.34	0.8	46.19	8.93	0.61	P	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11712	11712	C	G	MI.18331	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	953	318	A	G	gCc/gGc	4.86	1	0	probably_damaging	1	neutral	0.37	neutral	4.55	neutral	-2.75	deleterious	-3.65	medium_impact	2.05	0.66	neutral	0.53	neutral	4.12	23.80	deleterious	0.16	0.45	0.85	disease	0.76	disease	0.59	disease	0.62	disease	2	1	deleterious	0.19	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.07	medium_impact	0.9	medium_impact	0.62	0.8	46.19	8.93	0.56	P	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11714	11714	C	A	MI.18332	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	955	319	H	N	Cac/Aac	-3.19	0	0	probably_damaging	1	deleterious	0	neutral	3.89	deleterious	-6.23	deleterious	-6.66	high_impact	4.25	0.59	damaging	0.1	damaging	4.03	23.60	deleterious	0.09	0.35	0.78	disease	0.84	disease	0.78	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.24	0.8	47.71	9.36	0.41	N	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11714	11714	C	G	MI.18333	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	955	319	H	D	Cac/Gac	-3.19	0	0	probably_damaging	1	deleterious	0	neutral	3.89	deleterious	-6.85	deleterious	-8.57	high_impact	4.6	0.67	neutral	0.1	damaging	3.97	23.60	deleterious	0.04	0.35	0.77	disease	0.88	disease	0.83	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.43	high_impact	0.16	0.8	47.71	9.36	0.52	N	0.97	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11714	11714	C	T	MI.18334	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	955	319	H	Y	Cac/Tac	-3.19	0	0	probably_damaging	1	deleterious	0	neutral	4.25	neutral	-1.26	deleterious	-5.72	high_impact	4.25	0.63	neutral	0.09	damaging	3.85	23.40	deleterious	0.05	0.35	0.7	disease	0.89	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.26	0.8	47.71	9.36	0.4	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11715	11715	A	T	MI.18335	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	956	319	H	L	cAc/cTc	7.17	1	0	probably_damaging	1	deleterious	0	neutral	3.95	deleterious	-3.82	deleterious	-10.48	high_impact	4.6	0.59	damaging	0.09	damaging	3.99	23.60	deleterious	0.03	0.35	0.55	disease	0.92	disease	0.78	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.43	high_impact	0.20	0.8	47.71	9.36	0.66	P	0.96	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11715	11715	A	C	MI.18336	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	956	319	H	P	cAc/cCc	7.17	1	0	probably_damaging	1	deleterious	0	neutral	3.88	deleterious	-7.23	deleterious	-9.53	high_impact	4.6	0.62	neutral	0.09	damaging	3.39	23.00	deleterious	0.03	0.35	0.82	disease	0.9	disease	0.86	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.43	high_impact	0.14	0.8	47.71	9.36	0.64	P	0.95	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11715	11715	A	G	MI.18337	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	956	319	H	R	cAc/cGc	7.17	1	0	probably_damaging	1	deleterious	0	neutral	3.89	deleterious	-6.28	deleterious	-7.61	high_impact	4.6	0.6	damaging	0.11	damaging	3.14	22.60	deleterious	0.03	0.35	0.75	disease	0.9	disease	0.82	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.43	high_impact	0.31	0.8	47.71	9.36	0.65	P	0.97	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11716	11716	C	A	MI.18338	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	957	319	H	Q	caC/caA	8.55	1	0	probably_damaging	1	deleterious	0	neutral	3.97	deleterious	-3.46	deleterious	-7.6	high_impact	3.7	0.62	neutral	0.1	damaging	4.02	23.60	deleterious	0.04	0.35	0.77	disease	0.85	disease	0.79	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.53	high_impact	0.24	0.8	47.71	9.36	0.64	P	0.93	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11716	11716	C	G	MI.18339	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	957	319	H	Q	caC/caG	8.55	1	0	probably_damaging	1	deleterious	0	neutral	3.97	deleterious	-3.46	deleterious	-7.6	high_impact	3.7	0.62	neutral	0.1	damaging	3.64	23.20	deleterious	0.04	0.35	0.77	disease	0.85	disease	0.79	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.53	high_impact	0.24	0.8	47.71	9.36	0.64	P	0.93	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8549	8549	C	T	MI.1834	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	184	62	H	Y	Cat/Tat	2.9	1	0	possibly_damaging	0.85	neutral	1	neutral	1.84	neutral	-2.06	neutral	-0.57	medium_impact	2	0.97	neutral	0.4	neutral	3.59	23.20	deleterious	0.82750062	0.90	0.37	neutral	0.17	neutral	0.54	disease	0.13	neutral	8	0.85	neutral	0.58	deleterious	0	NA	0.56	deleterious	-1.47	low_impact	1.98	high_impact	0.62	medium_impact	0.33	0.85	NA	NA	0.44	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11717	11717	G	C	MI.18340	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	958	320	G	R	Ggg/Cgg	-4.81	0	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-4.07	deleterious	-7.6	high_impact	4.55	0.42	damaging	0.02	damaging	4.05	23.70	deleterious	0.02	0.35	0.87	disease	0.91	disease	0.78	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.21	0.8	46.62	8.84	0.56	P	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11717	11717	G	T	MI.18341	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	958	320	G	W	Ggg/Tgg	-4.81	0	0	probably_damaging	1	deleterious	0	neutral	4.4	deleterious	-5.99	deleterious	-7.61	high_impact	4.55	0.39	damaging	0.02	damaging	4.51	24.30	deleterious	0.03	0.35	0.4	neutral	0.92	disease	0.73	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.14	0.8	46.62	8.84	0.49	N	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11718	11718	G	A	MI.18342	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	959	320	G	E	gGg/gAg	9.01	1	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-3.8	deleterious	-7.6	high_impact	4.55	0.36	damaging	0.03	damaging	3.99	23.60	deleterious	0.02	0.35	0.89	disease	0.9	disease	0.77	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.26	0.8	46.62	8.84	0.76	P	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11718	11718	G	T	MI.18343	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	959	320	G	V	gGg/gTg	9.01	1	0	probably_damaging	1	deleterious	0	neutral	4.53	neutral	-1.98	deleterious	-8.55	high_impact	4.55	0.4	damaging	0.03	damaging	3.90	23.50	deleterious	0.02	0.35	0.49	neutral	0.9	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.38	high_impact	0.15	0.8	46.62	8.84	0.7	P	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11718	11718	G	C	MI.18344	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	959	320	G	A	gGg/gCg	9.01	1	0	probably_damaging	1	deleterious	0.02	neutral	4.68	neutral	0.7	deleterious	-5.68	medium_impact	2.92	0.48	damaging	0.07	damaging	3.22	22.70	deleterious	0.12	0.4	0.59	disease	0.73	disease	0.6	disease	0.65	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-0.75	medium_impact	1.76	medium_impact	0.44	0.8	46.62	8.84	0.58	P	0.76	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11720	11720	C	T	MI.18345	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	961	321	L	F	Ctt/Ttt	-11.71	0	0	probably_damaging	1	neutral	0.12	neutral	4.69	neutral	-0.4	deleterious	-3.64	low_impact	1.7	0.52	damaging	0.17	damaging	4.07	23.70	deleterious	0.22	0.45	0.57	disease	0.64	disease	0.43	neutral	0.37	neutral	3	1	deleterious	0.06	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	-0.28	medium_impact	0.56	medium_impact	0.56	0.8	44.01	8.04	0.36	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11720	11720	C	G	MI.18346	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	961	321	L	V	Ctt/Gtt	-11.71	0	0	probably_damaging	1	deleterious	0.02	neutral	4.51	neutral	-1.64	deleterious	-2.82	medium_impact	2.58	0.54	damaging	0.07	damaging	3.57	23.10	deleterious	0.25	0.45	0.67	disease	0.63	disease	0.56	disease	0.51	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-0.75	medium_impact	1.43	medium_impact	0.55	0.8	44.01	8.04	0.26	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11720	11720	C	A	MI.18347	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	961	321	L	I	Ctt/Att	-11.71	0	0	probably_damaging	1	neutral	0.12	neutral	4.45	neutral	-1.21	neutral	-1.87	medium_impact	2	0.56	damaging	0.11	damaging	4.25	23.90	deleterious	0.3	0.45	0.62	disease	0.65	disease	0.53	disease	0.39	neutral	2	1	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.28	medium_impact	0.85	medium_impact	0.59	0.8	44.01	8.04	0.31	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11721	11721	T	A	MI.18348	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	962	321	L	H	cTt/cAt	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.35	deleterious	-5.61	deleterious	-6.57	high_impact	4.38	0.5	damaging	0.04	damaging	4.21	23.90	deleterious	0.03	0.35	0.96	disease	0.83	disease	0.72	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.21	high_impact	0.33	0.8	44.01	8.04	0.38	N	0.96	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11721	11721	T	G	MI.18349	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	962	321	L	R	cTt/cGt	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.36	deleterious	-5.09	deleterious	-5.66	high_impact	4.38	0.55	damaging	0.04	damaging	4.31	24.00	deleterious	0.02	0.35	0.94	disease	0.9	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.21	high_impact	0.15	0.8	44.01	8.04	0.4	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8550	8550	A	G	MI.1835	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	185	62	H	R	cAt/cGt	5.22	1	0	possibly_damaging	0.9	neutral	0.35	neutral	1.87	neutral	-1.9	neutral	-1.88	medium_impact	2.56	0.97	neutral	0.18	damaging	1.90	15.60	deleterious	0.85853464	0.90	0.42	neutral	0.15	neutral	0.61	disease	0.11	neutral	8	0.91	neutral	0.23	neutral	0	NA	0.62	deleterious	-1.66	low_impact	0.14	medium_impact	1.1	medium_impact	0.26	0.85	NA	NA	0.64	P	0.58	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11721	11721	T	C	MI.18350	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	962	321	L	P	cTt/cCt	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.35	deleterious	-5.61	deleterious	-6.62	high_impact	4.03	0.5	damaging	0.04	damaging	3.99	23.60	deleterious	0.02	0.35	0.96	disease	0.85	disease	0.74	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	2.86	high_impact	0.39	0.8	44.01	8.04	0.33	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11723	11723	A	G	MI.18351	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	964	322	T	A	Aca/Gca	-16.09	0	0	probably_damaging	1	neutral	0.18	neutral	4.59	neutral	0.29	deleterious	-3.78	medium_impact	2.78	0.74	neutral	0.25	damaging	2.34	18.44	deleterious	0.25	0.45	0.43	neutral	0.54	disease	0.41	neutral	0.39	neutral	2	1	deleterious	0.09	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	-0.17	medium_impact	1.62	medium_impact	0.46	0.8	46.84	9.51	0.37	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11723	11723	A	C	MI.18352	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	964	322	T	P	Aca/Cca	-16.09	0	0	probably_damaging	1	deleterious	0.01	neutral	4.53	deleterious	-3.71	deleterious	-5	high_impact	3.98	0.65	neutral	0.13	damaging	3.58	23.20	deleterious	0.05	0.35	0.85	disease	0.9	disease	0.72	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-0.92	medium_impact	2.81	high_impact	0.35	0.8	46.84	9.51	0.31	N	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11723	11723	A	T	MI.18353	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	964	322	T	S	Aca/Tca	-16.09	0	0	probably_damaging	1	neutral	0.42	neutral	4.67	neutral	-0.07	deleterious	-3.32	low_impact	1.84	0.75	neutral	0.22	damaging	3.34	22.90	deleterious	0.34	0.5	0.43	neutral	0.71	disease	0.38	neutral	0.48	neutral	0	1	deleterious	0.21	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.12	medium_impact	0.69	medium_impact	0.65	0.8	46.84	9.51	0.32	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11724	11724	C	A	MI.18354	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	965	322	T	K	aCa/aAa	3.94	0.91	0	probably_damaging	1	deleterious	0.01	neutral	4.54	deleterious	-3.06	deleterious	-5	high_impact	3.98	0.7	neutral	0.13	damaging	4.51	24.30	deleterious	0.06	0.35	0.72	disease	0.91	disease	0.7	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-0.92	medium_impact	2.81	high_impact	0.50	0.8	46.84	9.51	0.46	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11724	11724	C	T	MI.18355	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	965	322	T	M	aCa/aTa	3.94	0.91	0	probably_damaging	1	deleterious	0	neutral	4.66	neutral	-0.17	deleterious	-4.51	medium_impact	3.43	0.74	neutral	0.16	damaging	4.09	23.70	deleterious	0.11	0.4	0.69	disease	0.8	disease	0.58	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.54	low_impact	-1.48	low_impact	2.27	high_impact	0.53	0.8	46.84	9.51	0.44	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11726	11726	T	A	MI.18356	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	967	323	S	T	Tcc/Acc	-7.57	0	0	probably_damaging	1	deleterious	0	neutral	4.47	neutral	0	deleterious	-2.87	medium_impact	2.98	0.45	damaging	0.07	damaging	3.91	23.50	deleterious	0.22	0.45	0.49	neutral	0.7	disease	0.65	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.54	low_impact	-1.48	low_impact	1.82	medium_impact	0.46	0.8	47.06	9.41	0.37	N	0.73	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11726	11726	T	C	MI.18357	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	967	323	S	P	Tcc/Ccc	-7.57	0	0	probably_damaging	1	deleterious	0	neutral	4.4	deleterious	-3.34	deleterious	-4.78	high_impact	4.24	0.36	damaging	0.05	damaging	4.09	23.70	deleterious	0.04	0.35	0.8	disease	0.86	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.07	high_impact	0.19	0.8	47.06	9.41	0.57	P	0.99	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11726	11726	T	G	MI.18358	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	967	323	S	A	Tcc/Gcc	-7.57	0	0	probably_damaging	1	neutral	0.06	neutral	4.46	neutral	-0.77	deleterious	-2.87	medium_impact	3	0.46	damaging	0.14	damaging	3.80	23.40	deleterious	0.2	0.45	0.5	disease	0.6	disease	0.6	disease	0.64	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.47	medium_impact	1.84	medium_impact	0.37	0.8	47.06	9.41	0.39	N	0.51	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11727	11727	C	G	MI.18359	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	968	323	S	C	tCc/tGc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.39	deleterious	-4.64	deleterious	-4.78	high_impact	4.58	0.39	damaging	0.03	damaging	3.66	23.20	deleterious	0.07	0.35	0.89	disease	0.82	disease	0.64	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.41	high_impact	0.28	0.8	47.06	9.41	0.7	P	1.00	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8550	8550	A	C	MI.1836	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	185	62	H	P	cAt/cCt	5.22	1	0	probably_damaging	0.94	neutral	0.2	neutral	1.85	deleterious	-3.5	neutral	-1.76	low_impact	0.85	0.98	neutral	0.61	neutral	2.18	17.40	deleterious	0.47136521	0.85	0.65	disease	0.34	neutral	0.51	disease	0.26	neutral	5	0.96	neutral	0.13	neutral	-2	neutral	0.72	deleterious	-1.89	low_impact	-0.05	medium_impact	-0.37	medium_impact	0.38	0.85	NA	NA	0.65	P	0.81	polymorphism	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11727	11727	C	T	MI.18360	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	968	323	S	F	tCc/tTc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.39	deleterious	-3.69	deleterious	-5.73	high_impact	4.58	0.41	damaging	0.03	damaging	4.30	24.00	deleterious	0.07	0.35	0.64	disease	0.9	disease	0.64	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.41	high_impact	0.12	0.8	47.06	9.41	0.68	P	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11727	11727	C	A	MI.18361	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	968	323	S	Y	tCc/tAc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	4.4	deleterious	-3.67	deleterious	-5.73	high_impact	4.58	0.39	damaging	0.04	damaging	4.30	24.00	deleterious	0.06	0.35	0.7	disease	0.88	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.41	high_impact	0.20	0.8	47.06	9.41	0.73	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11729	11729	T	A	MI.18362	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	970	324	S	T	Tca/Aca	-12.86	0	0	probably_damaging	1	neutral	0.07	neutral	4.58	neutral	-1.19	deleterious	-2.81	high_impact	3.54	0.45	damaging	0.08	damaging	3.91	23.50	deleterious	0.23	0.45	0.56	disease	0.71	disease	0.64	disease	0.66	disease	3	1	deleterious	0.04	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	-0.43	medium_impact	2.38	high_impact	0.44	0.8	45.97	8.92	0.36	N	0.73	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11729	11729	T	C	MI.18363	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	970	324	S	P	Tca/Cca	-12.86	0	0	probably_damaging	1	neutral	0.05	neutral	4.47	deleterious	-3.22	deleterious	-4.75	medium_impact	2.6	0.35	damaging	0.08	damaging	4.09	23.70	deleterious	0.04	0.35	0.86	disease	0.85	disease	0.76	disease	0.74	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.52	medium_impact	1.45	medium_impact	0.33	0.8	45.97	8.92	0.5	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11729	11729	T	G	MI.18364	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	970	324	S	A	Tca/Gca	-12.86	0	0	probably_damaging	1	neutral	0.07	neutral	4.77	neutral	1.5	deleterious	-2.85	medium_impact	2.61	0.46	damaging	0.11	damaging	3.79	23.40	deleterious	0.24	0.45	0.54	disease	0.6	disease	0.65	disease	0.65	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.43	medium_impact	1.46	medium_impact	0.41	0.8	45.97	8.92	0.37	N	0.51	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11730	11730	C	T	MI.18365	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	971	324	S	L	tCa/tTa	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.66	neutral	-0.94	deleterious	-5.69	high_impact	4.17	0.42	damaging	0.03	damaging	4.76	24.70	deleterious	0.05	0.35	0.35	neutral	0.88	disease	0.63	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.54	low_impact	-1.48	low_impact	3	high_impact	0.35	0.8	45.97	8.92	0.68	P	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11730	11730	C	G	MI.18366	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	971	324	S	W	tCa/tGa	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.47	deleterious	-5.19	deleterious	-6.65	high_impact	4.51	0.43	damaging	0.04	damaging	4.46	24.20	deleterious	0.06	0.35	0.87	disease	0.88	disease	0.69	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.34	high_impact	0.14	0.8	45.97	8.92	0.67	P	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11732	11732	T	A	MI.18367	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	973	325	L	M	Tta/Ata	-11.94	0	0	benign	0.15	neutral	0.45	neutral	4.48	neutral	-2.68	neutral	0.72	neutral_impact	-0.92	0.78	neutral	0.96	neutral	1.75	14.67	neutral	0.26	0.45	0.57	disease	0.05	neutral	0.24	neutral	0.4	neutral	2	0.47	neutral	0.65	deleterious	-6	neutral	0.68	deleterious	-0.01	medium_impact	0.15	medium_impact	-2.04	low_impact	0.55	0.8	20.7	16.06	0.35	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11732	11732	T	G	MI.18368	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	973	325	L	V	Tta/Gta	-11.94	0	0	possibly_damaging	0.53	neutral	0.15	neutral	4.48	neutral	-2.38	neutral	-0.92	low_impact	1.01	0.82	neutral	0.95	neutral	1.13	11.40	neutral	0.26	0.45	0.52	disease	0.35	neutral	0.32	neutral	0.35	neutral	3	0.84	neutral	0.31	neutral	-3	neutral	0.71	deleterious	-0.77	medium_impact	-0.22	medium_impact	-0.13	medium_impact	0.57	0.8	20.7	16.06	0.43	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11733	11733	T	G	MI.18369	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	974	325	L	W	tTa/tGa	-0.2	0	0	probably_damaging	0.98	deleterious	0.01	neutral	4.39	deleterious	-6.39	deleterious	-3.52	medium_impact	2.5	0.73	neutral	0.47	neutral	3.82	23.40	deleterious	0.04	0.35	0.93	disease	0.63	disease	0.55	disease	0.78	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-2.31	low_impact	-0.92	medium_impact	1.35	medium_impact	0.26	0.8	20.7	16.06	0.34	N	0.82	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8550	8550	A	T	MI.1837	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	185	62	H	L	cAt/cTt	5.22	1	0	possibly_damaging	0.9	neutral	0.94	neutral	2.06	neutral	-0.05	neutral	0.72	neutral_impact	-0.26	0.98	neutral	0.9	neutral	1.03	10.83	neutral	0.63281019	0.85	0.1	neutral	0.09	neutral	0.36	neutral	0.04	neutral	9	0.89	neutral	0.52	deleterious	-3	neutral	0.58	deleterious	-1.66	low_impact	0.97	medium_impact	-1.32	low_impact	0.32	0.85	NA	NA	0.54	P	0.14	polymorphism	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11733	11733	T	C	MI.18370	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	974	325	L	S	tTa/tCa	-0.2	0	0	possibly_damaging	0.86	neutral	0.09	neutral	4.5	neutral	-2.71	deleterious	-2.64	low_impact	1.01	0.73	neutral	0.74	neutral	2.73	21.00	deleterious	0.05	0.35	0.35	neutral	0.48	neutral	0.34	neutral	0.46	neutral	1	0.96	neutral	0.12	neutral	-3	neutral	0.71	deleterious	-1.46	low_impact	-0.36	medium_impact	-0.13	medium_impact	0.28	0.8	20.7	16.06	0.41	N	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11734	11734	A	T	MI.18371	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	975	325	L	F	ttA/ttT	3.25	0.1	0	possibly_damaging	0.76	neutral	0.13	neutral	4.42	deleterious	-3.92	neutral	-2.23	low_impact	1.7	0.68	neutral	0.65	neutral	3.62	23.20	deleterious	0.17	0.45	0.59	disease	0.56	disease	0.52	disease	0.58	disease	2	0.91	neutral	0.19	neutral	-3	neutral	0.75	deleterious	-1.19	low_impact	-0.26	medium_impact	0.56	medium_impact	0.54	0.8	20.7	16.06	0.46	N	0.44	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11734	11734	A	C	MI.18372	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	975	325	L	F	ttA/ttC	3.25	0.1	0	possibly_damaging	0.76	neutral	0.13	neutral	4.42	deleterious	-3.92	neutral	-2.23	low_impact	1.7	0.68	neutral	0.65	neutral	3.48	23.10	deleterious	0.17	0.45	0.59	disease	0.56	disease	0.52	disease	0.58	disease	2	0.91	neutral	0.19	neutral	-3	neutral	0.75	deleterious	-1.19	low_impact	-0.26	medium_impact	0.56	medium_impact	0.54	0.8	20.7	16.06	0.45	N	0.44	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11735	11735	C	A	MI.18373	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	976	326	L	M	Cta/Ata	-0.2	0	0	possibly_damaging	0.61	neutral	0.18	neutral	4.18	deleterious	-3.89	neutral	-1.72	low_impact	1.79	0.66	neutral	0.64	neutral	3.80	23.40	deleterious	0.14	0.4	0.85	disease	0.49	neutral	0.55	disease	0.59	disease	2	0.83	neutral	0.29	neutral	-3	neutral	0.75	deleterious	-0.9	medium_impact	-0.17	medium_impact	0.65	medium_impact	0.50	0.8	12.42	12.51	0.37	N	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11735	11735	C	G	MI.18374	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	976	326	L	V	Cta/Gta	-0.2	0	0	possibly_damaging	0.81	deleterious	0	neutral	4.2	deleterious	-3.91	deleterious	-2.78	high_impact	4.47	0.56	damaging	0.5	neutral	3.51	23.10	deleterious	0.09	0.35	0.75	disease	0.58	disease	0.65	disease	0.65	disease	3	1	deleterious	0.1	neutral	5	deleterious	0.76	deleterious	-1.31	low_impact	-1.48	low_impact	3.3	high_impact	0.54	0.8	12.42	12.51	0.53	P	0.53	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11736	11736	T	G	MI.18375	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	977	326	L	R	cTa/cGa	-1.35	0	0.01	probably_damaging	0.98	deleterious	0	neutral	4.07	deleterious	-6.6	deleterious	-5.6	high_impact	4.47	0.54	damaging	0.37	neutral	4.24	23.90	deleterious	0.02	0.35	0.55	disease	0.85	disease	0.74	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.31	low_impact	-1.48	low_impact	3.3	high_impact	0.19	0.8	12.42	12.51	0.48	N	0.97	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11736	11736	T	C	MI.18376	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	977	326	L	P	cTa/cCa	-1.35	0	0.01	probably_damaging	0.98	deleterious	0	neutral	4.06	deleterious	-7.17	deleterious	-6.55	high_impact	4.47	0.48	damaging	0.46	neutral	4.09	23.70	deleterious	0.02	0.35	0.82	disease	0.82	disease	0.74	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.31	low_impact	-1.48	low_impact	3.3	high_impact	0.31	0.8	12.42	12.51	0.49	N	0.93	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11736	11736	T	A	MI.18377	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	977	326	L	Q	cTa/cAa	-1.35	0	0.01	probably_damaging	0.98	deleterious	0	neutral	4.06	deleterious	-6.77	deleterious	-5.56	high_impact	4.47	0.54	damaging	0.45	neutral	4.35	24.10	deleterious	0.03	0.35	0.58	disease	0.84	disease	0.64	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.31	low_impact	-1.48	low_impact	3.3	high_impact	0.31	0.8	12.42	12.51	0.46	N	0.93	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11738	11738	T	G	MI.18378	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	979	327	F	V	Ttc/Gtc	-0.43	0.3	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-7.46	deleterious	-6.63	high_impact	4.25	0.47	damaging	0.65	neutral	4.15	23.80	deleterious	0.04	0.35	0.63	disease	0.84	disease	0.75	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.24	0.8	47.06	9.31	0.54	P	0.84	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11738	11738	T	A	MI.18379	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	979	327	F	I	Ttc/Atc	-0.43	0.3	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-7.21	deleterious	-5.68	high_impact	4.59	0.51	damaging	0.75	neutral	4.49	24.30	deleterious	0.05	0.35	0.69	disease	0.83	disease	0.76	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.37	0.8	47.06	9.31	0.56	P	0.74	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8551	8551	T	A	MI.1838	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	186	62	H	Q	caT/caA	0.59	0.99	0	probably_damaging	0.94	neutral	0.23	neutral	1.86	neutral	-2.2	neutral	-1.84	medium_impact	2.56	0.97	neutral	0.23	damaging	4.17	23.80	deleterious	0.90489867	0.95	0.48	neutral	0.2	neutral	0.64	disease	0.14	neutral	7	0.96	neutral	0.15	neutral	1	deleterious	0.62	deleterious	-1.89	low_impact	-0.01	medium_impact	1.1	medium_impact	0.57	0.85	NA	NA	0.53	N	0.64	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11738	11738	T	C	MI.18380	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	979	327	F	L	Ttc/Ctc	-0.43	0.3	0	probably_damaging	1	deleterious	0	neutral	2.74	deleterious	-5.12	deleterious	-5.68	medium_impact	3.44	0.46	damaging	0.67	neutral	4.12	23.80	deleterious	0.03	0.35	0.64	disease	0.82	disease	0.69	disease	0.7	disease	4	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.40	0.8	47.06	9.31	0.47	N	0.78	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11739	11739	T	C	MI.18381	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	980	327	F	S	tTc/tCc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-9	deleterious	-7.58	high_impact	4.59	0.46	damaging	0.79	neutral	4.41	24.10	deleterious	0.01	0.35	0.65	disease	0.87	disease	0.72	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.20	0.8	47.06	9.31	0.59	P	0.11	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11739	11739	T	G	MI.18382	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	980	327	F	C	tTc/tGc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-10.27	deleterious	-7.58	high_impact	4.25	0.54	damaging	0.58	neutral	4.18	23.80	deleterious	0.02	0.35	0.81	disease	0.87	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.12	0.8	47.06	9.31	0.52	P	0.85	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11739	11739	T	A	MI.18383	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	980	327	F	Y	tTc/tAc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-5.93	deleterious	-2.85	high_impact	4.59	0.52	damaging	0.58	neutral	4.54	24.30	deleterious	0.08	0.35	0.68	disease	0.8	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.46	0.8	47.06	9.31	0.61	P	0.65	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11740	11740	C	G	MI.18384	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	981	327	F	L	ttC/ttG	5.78	1	0	probably_damaging	1	deleterious	0	neutral	2.74	deleterious	-5.12	deleterious	-5.68	medium_impact	3.44	0.46	damaging	0.67	neutral	4.49	24.30	deleterious	0.03	0.35	0.64	disease	0.82	disease	0.69	disease	0.7	disease	4	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.40	0.8	47.06	9.31	0.63	P	0.78	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11740	11740	C	A	MI.18385	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	981	327	F	L	ttC/ttA	5.78	1	0	probably_damaging	1	deleterious	0	neutral	2.74	deleterious	-5.12	deleterious	-5.68	medium_impact	3.44	0.46	damaging	0.67	neutral	4.72	24.60	deleterious	0.03	0.35	0.64	disease	0.82	disease	0.69	disease	0.7	disease	4	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	2.28	high_impact	0.40	0.8	47.06	9.31	0.63	P	0.78	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11741	11741	T	A	MI.18386	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	982	328	C	S	Tgc/Agc	-0.66	0.13	0	probably_damaging	1	neutral	0.05	neutral	4.66	neutral	0.01	deleterious	-8.92	medium_impact	2.12	0.6	neutral	0.62	neutral	3.58	23.20	deleterious	0.09	0.35	0.47	neutral	0.88	disease	0.64	disease	0.63	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.52	medium_impact	0.97	medium_impact	0.53	0.8	46.19	8.87	0.44	N	0.24	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11741	11741	T	G	MI.18387	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	982	328	C	G	Tgc/Ggc	-0.66	0.13	0	probably_damaging	1	deleterious	0.01	neutral	4.64	neutral	-0.88	deleterious	-10.84	high_impact	3.57	0.6	neutral	0.57	neutral	3.36	22.90	deleterious	0.08	0.35	0.63	disease	0.9	disease	0.69	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.92	medium_impact	2.41	high_impact	0.36	0.8	46.19	8.87	0.42	N	0.75	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11741	11741	T	C	MI.18388	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	982	328	C	R	Tgc/Cgc	-0.66	0.13	0	probably_damaging	1	deleterious	0.01	neutral	4.62	neutral	-1.73	deleterious	-10.76	high_impact	4.26	0.6	damaging	0.45	neutral	3.58	23.20	deleterious	0.05	0.35	0.58	disease	0.92	disease	0.79	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-0.92	medium_impact	3.09	high_impact	0.14	0.8	46.19	8.87	0.55	P	0.87	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11742	11742	G	A	MI.18389	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	983	328	C	Y	tGc/tAc	5.55	1	0	probably_damaging	1	neutral	0.27	neutral	4.65	neutral	-0.23	deleterious	-9.94	medium_impact	2.36	0.61	neutral	0.42	neutral	3.73	23.30	deleterious	0.09	0.35	0.57	disease	0.93	disease	0.73	disease	0.76	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.04	medium_impact	1.21	medium_impact	0.34	0.8	46.19	8.87	0.53	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8551	8551	T	G	MI.1839	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	186	62	H	Q	caT/caG	0.59	0.99	0	probably_damaging	0.94	neutral	0.23	neutral	1.86	neutral	-2.2	neutral	-1.84	medium_impact	2.56	0.97	neutral	0.23	damaging	3.86	23.50	deleterious	0.90489867	0.95	0.48	neutral	0.2	neutral	0.64	disease	0.14	neutral	7	0.96	neutral	0.15	neutral	1	deleterious	0.62	deleterious	-1.89	low_impact	-0.01	medium_impact	1.1	medium_impact	0.57	0.85	NA	NA	0.53	N	0.64	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11742	11742	G	T	MI.18390	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	983	328	C	F	tGc/tTc	5.55	1	0	probably_damaging	1	neutral	0.12	neutral	4.71	neutral	1.53	deleterious	-9.95	medium_impact	2.04	0.62	neutral	0.48	neutral	4.01	23.60	deleterious	0.11	0.4	0.51	disease	0.93	disease	0.68	disease	0.67	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	-0.28	medium_impact	0.89	medium_impact	0.28	0.8	46.19	8.87	0.55	P	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11742	11742	G	C	MI.18391	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	983	328	C	S	tGc/tCc	5.55	1	0	probably_damaging	1	neutral	0.05	neutral	4.66	neutral	0.01	deleterious	-8.92	medium_impact	2.12	0.6	neutral	0.62	neutral	3.29	22.80	deleterious	0.09	0.35	0.47	neutral	0.88	disease	0.64	disease	0.63	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.52	medium_impact	0.97	medium_impact	0.53	0.8	46.19	8.87	0.56	P	0.24	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11743	11743	C	A	MI.18392	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	984	328	C	W	tgC/tgA	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.61	neutral	-1.96	deleterious	-9.95	high_impact	4.26	0.58	damaging	0.45	neutral	4.73	24.60	deleterious	0.05	0.35	0.46	neutral	0.93	disease	0.76	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.09	high_impact	0.29	0.8	46.19	8.87	0.62	P	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11743	11743	C	G	MI.18393	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	984	328	C	W	tgC/tgG	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.61	neutral	-1.96	deleterious	-9.95	high_impact	4.26	0.58	damaging	0.45	neutral	4.40	24.10	deleterious	0.05	0.35	0.46	neutral	0.93	disease	0.76	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.09	high_impact	0.29	0.8	46.19	8.87	0.62	P	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11744	11744	C	A	MI.18394	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	985	329	L	M	Cta/Ata	-1.58	0	0	probably_damaging	1	deleterious	0.04	neutral	4.34	neutral	-2.19	neutral	-1.89	medium_impact	2.69	0.51	damaging	0.13	damaging	3.81	23.40	deleterious	0.31	0.45	0.52	disease	0.54	disease	0.68	disease	0.55	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-3.54	low_impact	-0.57	medium_impact	1.54	medium_impact	0.71	0.85	46.62	9.16	0.35	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11744	11744	C	G	MI.18395	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	985	329	L	V	Cta/Gta	-1.58	0	0	probably_damaging	1	neutral	0.05	neutral	4.45	neutral	-0.29	deleterious	-2.83	medium_impact	2.98	0.48	damaging	0.13	damaging	3.54	23.10	deleterious	0.23	0.45	0.52	disease	0.54	disease	0.68	disease	0.65	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.52	medium_impact	1.82	medium_impact	0.63	0.8	46.62	9.16	0.39	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11745	11745	T	G	MI.18396	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	986	329	L	R	cTa/cGa	-1.81	0	0	probably_damaging	1	deleterious	0	neutral	4.32	deleterious	-4.15	deleterious	-5.68	high_impact	4.46	0.42	damaging	0.09	damaging	4.29	24.00	deleterious	0.02	0.35	0.42	neutral	0.82	disease	0.79	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.29	high_impact	0.31	0.8	46.62	9.16	0.59	P	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11745	11745	T	A	MI.18397	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	986	329	L	Q	cTa/cAa	-1.81	0	0	probably_damaging	1	deleterious	0	neutral	4.37	deleterious	-4.25	deleterious	-5.68	high_impact	3.9	0.43	damaging	0.11	damaging	4.18	23.80	deleterious	0.04	0.35	0.31	neutral	0.83	disease	0.69	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.54	low_impact	-1.48	low_impact	2.73	high_impact	0.35	0.8	46.62	9.16	0.45	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11745	11745	T	C	MI.18398	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	986	329	L	P	cTa/cCa	-1.81	0	0	probably_damaging	1	deleterious	0	neutral	4.31	deleterious	-4.75	deleterious	-6.63	high_impact	4.46	0.39	damaging	0.11	damaging	4.02	23.60	deleterious	0.03	0.35	0.62	disease	0.78	disease	0.78	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.29	high_impact	0.28	0.8	46.62	9.16	0.62	P	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11747	11747	G	C	MI.18399	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	988	330	A	P	Gca/Cca	-0.2	0.54	0	probably_damaging	1	deleterious	0	neutral	4.34	deleterious	-5.96	deleterious	-4.74	high_impact	4.36	0.69	neutral	0.08	damaging	3.93	23.50	deleterious	0.02	0.35	0.23	neutral	0.83	disease	0.81	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.54	low_impact	-1.48	low_impact	3.19	high_impact	0.64	0.8	47.28	9.3	0.54	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8612	8612	T	A	MI.184	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	86	29	L	Q	cTa/cAa	-2.42	0	0	probably_damaging	1	deleterious	0.01	neutral	4.28	neutral	-2.63	deleterious	-4.23	medium_impact	3.19	0.83	neutral	0.18	damaging	3.88	23.50	deleterious	0.27	0.65	0.76	disease	0.57	disease	0.55	disease	0.66	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.6	low_impact	-0.84	medium_impact	1.64	medium_impact	0.58	0.9	17.26	17.02	0.33	N	0.81	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8552	8552	T	C	MI.1840	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	187	63	S	P	Tca/Cca	7.53	1	0	probably_damaging	0.94	neutral	0.18	neutral	1.31	deleterious	-4.21	deleterious	-3.19	medium_impact	3.09	0.99	neutral	0.27	damaging	4.04	23.70	deleterious	0.36812856	0.85	0.57	disease	0.35	neutral	0.66	disease	0.31	neutral	4	0.96	neutral	0.12	neutral	1	deleterious	0.70	deleterious	-1.89	low_impact	-0.08	medium_impact	1.55	medium_impact	0.29	0.85	NA	NA	0.68	P	0.71	disease_causing	0.99	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11747	11747	G	A	MI.18400	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	988	330	A	T	Gca/Aca	-0.2	0.54	0	probably_damaging	1	deleterious	0.04	neutral	4.38	deleterious	-3.02	deleterious	-3.79	medium_impact	3.04	0.64	neutral	0.11	damaging	4.33	24.00	deleterious	0.1	0.4	0.45	neutral	0.77	disease	0.64	disease	0.56	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-0.57	medium_impact	1.88	medium_impact	0.73	0.85	47.28	9.3	0.27	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11747	11747	G	T	MI.18401	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	988	330	A	S	Gca/Tca	-0.2	0.54	0	probably_damaging	1	neutral	0.15	neutral	4.42	neutral	-2.1	deleterious	-2.83	medium_impact	2.58	0.62	neutral	0.16	damaging	3.80	23.40	deleterious	0.18	0.45	0.46	neutral	0.76	disease	0.61	disease	0.4	neutral	2	1	deleterious	0.08	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.22	medium_impact	1.43	medium_impact	0.65	0.8	47.28	9.3	0.33	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11748	11748	C	T	MI.18402	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	989	330	A	V	gCa/gTa	6.01	1	0	probably_damaging	1	neutral	0.24	neutral	4.59	neutral	-0.95	deleterious	-3.8	low_impact	1.82	0.63	neutral	0.11	damaging	4.52	24.30	deleterious	0.11	0.4	0.38	neutral	0.73	disease	0.69	disease	0.56	disease	1	1	deleterious	0.12	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	-0.08	medium_impact	0.68	medium_impact	0.68	0.85	47.28	9.3	0.58	P	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11748	11748	C	G	MI.18403	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	989	330	A	G	gCa/gGa	6.01	1	0	probably_damaging	1	deleterious	0.01	neutral	4.34	deleterious	-4	deleterious	-3.79	medium_impact	2.69	0.6	neutral	0.12	damaging	3.96	23.60	deleterious	0.09	0.35	0.23	neutral	0.74	disease	0.64	disease	0.65	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.71	deleterious	-3.54	low_impact	-0.92	medium_impact	1.54	medium_impact	0.73	0.85	47.28	9.3	0.53	P	0.79	polymorphism	1	0.09	.	.	.	.	.	.	COSM6716748	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11748	11748	C	A	MI.18404	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	989	330	A	E	gCa/gAa	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.34	deleterious	-5.51	deleterious	-4.74	high_impact	4.01	0.68	neutral	0.1	damaging	4.63	24.50	deleterious	0.02	0.35	0.35	neutral	0.85	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	2.84	high_impact	0.43	0.8	47.28	9.3	0.59	P	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11750	11750	A	T	MI.18405	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	991	331	N	Y	Aac/Tac	-8.26	0	0	probably_damaging	1	deleterious	0.04	neutral	4.53	neutral	-1.86	deleterious	-7.6	medium_impact	3.06	0.52	damaging	0.09	damaging	3.88	23.50	deleterious	0.05	0.35	0.78	disease	0.85	disease	0.73	disease	0.72	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-0.57	medium_impact	1.9	medium_impact	0.24	0.8	46.84	9.35	0.29	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11750	11750	A	G	MI.18406	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	991	331	N	D	Aac/Gac	-8.26	0	0	probably_damaging	1	deleterious	0.02	neutral	4.59	neutral	0.19	deleterious	-4.75	medium_impact	3.25	0.55	damaging	0.12	damaging	3.98	23.60	deleterious	0.28	0.45	0.64	disease	0.75	disease	0.76	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-0.75	medium_impact	2.09	high_impact	0.28	0.8	46.84	9.35	0.32	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11750	11750	A	C	MI.18407	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	991	331	N	H	Aac/Cac	-8.26	0	0	probably_damaging	1	deleterious	0	neutral	4.54	neutral	-1.1	deleterious	-4.75	high_impact	3.64	0.54	damaging	0.13	damaging	3.18	22.70	deleterious	0.2	0.45	0.79	disease	0.77	disease	0.78	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.48	high_impact	0.25	0.8	46.84	9.35	0.34	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11751	11751	A	C	MI.18408	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	992	331	N	T	aAc/aCc	8.55	1	0	probably_damaging	1	neutral	0.09	neutral	4.59	neutral	-0.16	deleterious	-5.7	medium_impact	3.21	0.56	damaging	0.11	damaging	3.40	23.00	deleterious	0.15	0.4	0.63	disease	0.79	disease	0.68	disease	0.67	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.36	medium_impact	2.05	high_impact	0.38	0.8	46.84	9.35	0.6	P	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11751	11751	A	T	MI.18409	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	992	331	N	I	aAc/aTc	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.58	neutral	-1.02	deleterious	-8.54	high_impact	4.11	0.51	damaging	0.12	damaging	3.89	23.50	deleterious	0.07	0.35	0.83	disease	0.86	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.94	high_impact	0.16	0.8	46.84	9.35	0.64	P	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8552	8552	T	G	MI.1841	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	187	63	S	A	Tca/Gca	7.53	1	0	possibly_damaging	0.78	neutral	0.48	neutral	1.39	neutral	-2.12	neutral	-1.99	medium_impact	3.44	1	neutral	0.5	neutral	3.85	23.40	deleterious	0.55776640	0.85	0.36	neutral	0.14	neutral	0.64	disease	0.22	neutral	6	0.76	neutral	0.35	neutral	0	NA	0.55	deleterious	-1.28	low_impact	0.27	medium_impact	1.85	medium_impact	0.37	0.85	NA	NA	0.69	P	0.37	disease_causing	0.89	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11751	11751	A	G	MI.18410	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	992	331	N	S	aAc/aGc	8.55	1	0	probably_damaging	1	neutral	0.05	neutral	4.63	neutral	0.58	deleterious	-4.74	medium_impact	3	0.51	damaging	0.12	damaging	3.08	22.50	deleterious	0.29	0.45	0.62	disease	0.78	disease	0.68	disease	0.67	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.52	medium_impact	1.84	medium_impact	0.33	0.8	46.84	9.35	0.62	P	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11752	11752	C	A	MI.18411	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	993	331	N	K	aaC/aaA	8.55	1	0	probably_damaging	1	deleterious	0.01	neutral	4.64	neutral	0.32	deleterious	-5.7	high_impact	4.11	0.49	damaging	0.09	damaging	4.55	24.30	deleterious	0.18	0.45	0.52	disease	0.79	disease	0.71	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-0.92	medium_impact	2.94	high_impact	0.39	0.8	46.84	9.35	0.62	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11752	11752	C	G	MI.18412	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	993	331	N	K	aaC/aaG	8.55	1	0	probably_damaging	1	deleterious	0.01	neutral	4.64	neutral	0.32	deleterious	-5.7	high_impact	4.11	0.49	damaging	0.09	damaging	4.15	23.80	deleterious	0.18	0.45	0.52	disease	0.79	disease	0.71	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-0.92	medium_impact	2.94	high_impact	0.39	0.8	46.84	9.35	0.62	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11753	11753	T	C	MI.18413	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	994	332	S	P	Tca/Cca	-3.42	0	0	benign	0.08	neutral	0.06	neutral	4.46	deleterious	-3.68	deleterious	-2.83	medium_impact	2.73	0.6	neutral	0.42	neutral	2.24	17.79	deleterious	0.04	0.35	0.61	disease	0.78	disease	0.66	disease	0.75	disease	5	0.93	neutral	0.49	deleterious	-3	neutral	0.30	neutral	0.28	medium_impact	-0.47	medium_impact	1.58	medium_impact	0.24	0.8	21.13	15.25	0.34	N	0.95	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11753	11753	T	G	MI.18414	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	994	332	S	A	Tca/Gca	-3.42	0	0	possibly_damaging	0.52	neutral	0.16	neutral	4.57	neutral	-0.64	neutral	-1.55	low_impact	1.3	0.7	neutral	0.67	neutral	2.01	16.28	deleterious	0.3	0.45	0.36	neutral	0.26	neutral	0.51	disease	0.45	neutral	1	0.83	neutral	0.32	neutral	-3	neutral	0.20	neutral	-0.75	medium_impact	-0.2	medium_impact	0.16	medium_impact	0.41	0.8	21.13	15.25	0.43	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11753	11753	T	A	MI.18415	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	994	332	S	T	Tca/Aca	-3.42	0	0	possibly_damaging	0.77	neutral	0.99	neutral	4.56	neutral	-0.8	neutral	1.44	neutral_impact	-0.7	0.72	neutral	0.96	neutral	-0.39	0.41	neutral	0.27	0.45	0.28	neutral	0.04	neutral	0.13	neutral	0.21	neutral	6	0.77	neutral	0.61	deleterious	-3	neutral	0.23	neutral	-1.21	low_impact	1.32	medium_impact	-1.82	low_impact	0.59	0.8	21.13	15.25	0.4	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11754	11754	C	T	MI.18416	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	995	332	S	L	tCa/tTa	0.49	0.01	0	possibly_damaging	0.81	neutral	0.81	neutral	4.71	neutral	0.47	deleterious	-3.03	neutral_impact	0.6	0.71	neutral	0.72	neutral	3.03	22.30	deleterious	0.08	0.35	0.38	neutral	0.5	neutral	0.28	neutral	0.36	neutral	3	0.78	neutral	0.5	deleterious	-3	neutral	0.35	neutral	-1.31	low_impact	0.56	medium_impact	-0.53	medium_impact	0.34	0.8	21.13	15.25	0.33	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11754	11754	C	G	MI.18417	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	995	332	S	W	tCa/tGa	0.49	0.01	0	probably_damaging	0.99	neutral	0.05	neutral	4.45	deleterious	-4.42	deleterious	-4.04	medium_impact	2.17	0.69	neutral	0.45	neutral	4.44	24.20	deleterious	0.05	0.35	0.88	disease	0.73	disease	0.61	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.80	deleterious	-2.59	low_impact	-0.52	medium_impact	1.02	medium_impact	0.09	0.8	21.13	15.25	0.32	N	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11756	11756	A	T	MI.18418	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	997	333	N	Y	Aac/Tac	-14.94	0	0	probably_damaging	1	neutral	1	neutral	4.64	neutral	-0.78	deleterious	-6.76	medium_impact	2.31	0.77	neutral	0.38	neutral	3.89	23.50	deleterious	0.09	0.35	0.58	disease	0.87	disease	0.59	disease	0.67	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.81	deleterious	-3.54	low_impact	1.88	high_impact	1.16	medium_impact	0.30	0.8	46.84	9.38	0.19	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11756	11756	A	G	MI.18419	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	997	333	N	D	Aac/Gac	-14.94	0	0	probably_damaging	1	neutral	0.2	neutral	4.62	neutral	-1.26	deleterious	-4.18	high_impact	3.67	0.73	neutral	0.43	neutral	3.98	23.60	deleterious	0.34	0.5	0.44	neutral	0.79	disease	0.72	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	-0.14	medium_impact	2.51	high_impact	0.45	0.8	46.84	9.38	0.46	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8552	8552	T	A	MI.1842	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	187	63	S	T	Tca/Aca	7.53	1	0	possibly_damaging	0.85	neutral	1	neutral	1.36	neutral	-2.74	neutral	-1.99	medium_impact	3.44	1	neutral	0.43	neutral	4.05	23.70	deleterious	0.54043948	0.85	0.45	neutral	0.19	neutral	0.59	disease	0.21	neutral	6	0.85	neutral	0.58	deleterious	0	NA	0.63	deleterious	-1.47	low_impact	1.98	high_impact	1.85	medium_impact	0.45	0.85	NA	NA	0.56	P	0.46	disease_causing	0.97	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11756	11756	A	C	MI.18420	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	997	333	N	H	Aac/Cac	-14.94	0	0	probably_damaging	1	neutral	0.54	neutral	4.62	neutral	-1.04	deleterious	-4.28	medium_impact	3.33	0.75	neutral	0.3	neutral	3.23	22.80	deleterious	0.23	0.45	0.62	disease	0.81	disease	0.65	disease	0.66	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	0.24	medium_impact	2.17	high_impact	0.37	0.8	46.84	9.38	0.25	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11757	11757	A	G	MI.18421	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	998	333	N	S	aAc/aGc	5.55	0.95	0	probably_damaging	1	neutral	0.41	neutral	4.69	neutral	0.49	deleterious	-3.83	low_impact	1.45	0.74	neutral	0.61	neutral	1.94	15.84	deleterious	0.39	0.5	0.32	neutral	0.62	disease	0.38	neutral	0.34	neutral	3	1	deleterious	0.21	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	0.11	medium_impact	0.31	medium_impact	0.33	0.8	46.84	9.38	0.48	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11757	11757	A	T	MI.18422	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	998	333	N	I	aAc/aTc	5.55	0.95	0	probably_damaging	1	neutral	0.4	neutral	4.88	neutral	3.27	deleterious	-7.46	low_impact	1.48	0.73	neutral	0.5	neutral	3.89	23.50	deleterious	0.09	0.4	0.27	neutral	0.89	disease	0.46	neutral	0.38	neutral	2	1	deleterious	0.2	neutral	-2	neutral	0.75	deleterious	-3.54	low_impact	0.1	medium_impact	0.34	medium_impact	0.27	0.8	46.84	9.38	0.45	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11757	11757	A	C	MI.18423	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	998	333	N	T	aAc/aCc	5.55	0.95	0	probably_damaging	1	neutral	0.4	neutral	4.67	neutral	0.63	deleterious	-4.48	low_impact	1.59	0.72	neutral	0.58	neutral	2.26	17.90	deleterious	0.19	0.45	0.3	neutral	0.69	disease	0.35	neutral	0.35	neutral	3	1	deleterious	0.2	neutral	-2	neutral	0.71	deleterious	-3.54	low_impact	0.1	medium_impact	0.45	medium_impact	0.43	0.8	46.84	9.38	0.48	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11758	11758	C	A	MI.18424	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	999	333	N	K	aaC/aaA	2.1	0.91	0	probably_damaging	1	neutral	0.29	neutral	4.63	neutral	-0.76	deleterious	-4.96	high_impact	3.67	0.78	neutral	0.36	neutral	4.56	24.40	deleterious	0.24	0.45	0.42	neutral	0.85	disease	0.73	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.02	medium_impact	2.51	high_impact	0.62	0.8	46.84	9.38	0.39	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11758	11758	C	G	MI.18425	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	999	333	N	K	aaC/aaG	2.1	0.91	0	probably_damaging	1	neutral	0.29	neutral	4.63	neutral	-0.76	deleterious	-4.96	high_impact	3.67	0.78	neutral	0.36	neutral	4.14	23.80	deleterious	0.24	0.45	0.42	neutral	0.85	disease	0.73	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.02	medium_impact	2.51	high_impact	0.62	0.8	46.84	9.38	0.42	N	0.99	polymorphism	1	0.06	rs28735834	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11759	11759	T	C	MI.18426	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1000	334	Y	H	Tac/Cac	-1.12	0.01	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-3.83	deleterious	-4.74	high_impact	4.04	0.55	damaging	0.08	damaging	3.81	23.40	deleterious	0.12	0.4	0.68	disease	0.87	disease	0.86	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.09	0.8	47.28	9.51	0.45	N	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11759	11759	T	A	MI.18427	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1000	334	Y	N	Tac/Aac	-1.12	0.01	0	probably_damaging	1	neutral	0.06	neutral	4.43	deleterious	-3.49	deleterious	-8.52	high_impact	4.04	0.52	damaging	0.1	damaging	4.39	24.10	deleterious	0.06	0.35	0.62	disease	0.89	disease	0.8	disease	0.75	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	-0.47	medium_impact	2.87	high_impact	0.03	0.8	47.28	9.51	0.49	N	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11759	11759	T	G	MI.18428	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1000	334	Y	D	Tac/Gac	-1.12	0.01	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-4.25	deleterious	-9.47	high_impact	4.04	0.61	neutral	0.11	damaging	4.14	23.80	deleterious	0.03	0.35	0.69	disease	0.91	disease	0.86	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.04	0.8	47.28	9.51	0.49	N	0.99	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11760	11760	A	T	MI.18429	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1001	334	Y	F	tAc/tTc	5.78	1	0	probably_damaging	1	deleterious	0.02	neutral	4.48	neutral	-1.89	deleterious	-3.79	medium_impact	3.48	0.53	damaging	0.1	damaging	3.58	23.20	deleterious	0.17	0.45	0.29	neutral	0.86	disease	0.73	disease	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-3.54	low_impact	-0.75	medium_impact	2.32	high_impact	0.34	0.8	47.28	9.51	0.58	P	0.79	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8553	8553	C	T	MI.1843	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	188	63	S	L	tCa/tTa	7.53	1	0	possibly_damaging	0.9	neutral	0.33	neutral	1.38	neutral	-2.09	deleterious	-3.02	medium_impact	2.08	1	neutral	0.82	neutral	3.77	23.40	deleterious	0.36619744	0.85	0.31	neutral	0.3	neutral	0.48	neutral	0.21	neutral	6	0.91	neutral	0.22	neutral	0	NA	0.66	deleterious	-1.66	low_impact	0.12	medium_impact	0.69	medium_impact	0.72	0.85	NA	NA	0.7	P	0.55	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11760	11760	A	G	MI.18430	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1001	334	Y	C	tAc/tGc	5.78	1	0	probably_damaging	1	deleterious	0	neutral	4.45	neutral	-2.54	deleterious	-8.49	high_impact	3.69	0.56	damaging	0.09	damaging	3.69	23.30	deleterious	0.04	0.35	0.7	disease	0.9	disease	0.83	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	2.53	high_impact	0.03	0.8	47.28	9.51	0.66	P	1.00	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11760	11760	A	C	MI.18431	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1001	334	Y	S	tAc/tCc	5.78	1	0	probably_damaging	1	deleterious	0.02	neutral	4.5	neutral	-1.41	deleterious	-8.52	medium_impact	3.3	0.58	damaging	0.12	damaging	3.84	23.40	deleterious	0.06	0.35	0.33	neutral	0.9	disease	0.8	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.54	low_impact	-0.75	medium_impact	2.14	high_impact	0.06	0.8	47.28	9.51	0.6	P	0.95	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11762	11762	G	A	MI.18432	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1003	335	E	K	Gaa/Aaa	-6.19	0	0	possibly_damaging	0.89	neutral	0.08	neutral	4.6	neutral	-1.07	deleterious	-3.8	medium_impact	2.54	0.36	damaging	0.35	neutral	4.65	24.50	deleterious	0.07	0.35	0.5	disease	0.92	disease	0.76	disease	0.74	disease	5	0.97	neutral	0.1	neutral	0	NA	0.87	deleterious	-1.57	low_impact	-0.39	medium_impact	1.39	medium_impact	0.73	0.85	47.49	9.37	0.63	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11762	11762	G	C	MI.18433	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1003	335	E	Q	Gaa/Caa	-6.19	0	0	probably_damaging	0.95	deleterious	0.01	neutral	4.59	neutral	-1.08	deleterious	-2.85	medium_impact	3.29	0.4	damaging	0.5	neutral	3.52	23.10	deleterious	0.33	0.5	0.58	disease	0.83	disease	0.73	disease	0.71	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.82	deleterious	-1.92	low_impact	-0.92	medium_impact	2.13	high_impact	0.55	0.8	47.49	9.37	0.58	P	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11763	11763	A	G	MI.18434	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1004	335	E	G	gAa/gGa	9.01	1	0	probably_damaging	0.91	neutral	0.06	neutral	4.56	neutral	-2.46	deleterious	-6.64	medium_impact	3.29	0.43	damaging	0.59	neutral	4.48	24.30	deleterious	0.09	0.35	0.65	disease	0.85	disease	0.75	disease	0.73	disease	5	0.98	deleterious	0.08	neutral	1	deleterious	0.83	deleterious	-1.66	low_impact	-0.47	medium_impact	2.13	high_impact	0.16	0.8	47.49	9.37	0.76	P	0.53	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11763	11763	A	C	MI.18435	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1004	335	E	A	gAa/gCa	9.01	1	0	possibly_damaging	0.89	deleterious	0.01	neutral	4.58	neutral	-1.13	deleterious	-5.7	medium_impact	3.25	0.44	damaging	0.53	neutral	3.85	23.40	deleterious	0.1	0.4	0.43	neutral	0.79	disease	0.73	disease	0.69	disease	4	1	deleterious	0.06	neutral	4	deleterious	0.80	deleterious	-1.57	low_impact	-0.92	medium_impact	2.09	high_impact	0.20	0.8	47.49	9.37	0.7	P	0.74	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11763	11763	A	T	MI.18436	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1004	335	E	V	gAa/gTa	9.01	1	0	probably_damaging	0.98	deleterious	0	neutral	4.53	neutral	-1.98	deleterious	-6.65	high_impact	4.09	0.37	damaging	0.44	neutral	4.40	24.10	deleterious	0.06	0.35	0.39	neutral	0.9	disease	0.74	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.31	low_impact	-1.48	low_impact	2.92	high_impact	0.18	0.8	47.49	9.37	0.79	P	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11764	11764	A	T	MI.18437	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1005	335	E	D	gaA/gaT	8.55	1	0.01	benign	0.22	deleterious	0.02	neutral	4.63	neutral	-0.76	deleterious	-2.85	medium_impact	2.32	0.42	damaging	0.49	neutral	3.93	23.50	deleterious	0.36	0.5	0.65	disease	0.81	disease	0.59	disease	0.66	disease	3	0.98	neutral	0.4	neutral	1	deleterious	0.82	deleterious	-0.2	medium_impact	-0.75	medium_impact	1.17	medium_impact	0.61	0.8	47.49	9.37	0.73	P	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11764	11764	A	C	MI.18438	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1005	335	E	D	gaA/gaC	8.55	1	0.01	benign	0.22	deleterious	0.02	neutral	4.63	neutral	-0.76	deleterious	-2.85	medium_impact	2.32	0.42	damaging	0.49	neutral	3.81	23.40	deleterious	0.36	0.5	0.65	disease	0.81	disease	0.59	disease	0.66	disease	3	0.98	neutral	0.4	neutral	1	deleterious	0.82	deleterious	-0.2	medium_impact	-0.75	medium_impact	1.17	medium_impact	0.61	0.8	47.49	9.37	0.72	P	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11765	11765	C	T	MI.18439	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1006	336	R	C	Cgc/Tgc	0.03	0.91	0	probably_damaging	1	deleterious	0	neutral	4.41	deleterious	-5.33	deleterious	-7.53	medium_impact	3.2	0.51	damaging	0.19	damaging	5.11	25.30	deleterious	0.1	0.4	0.85	disease	0.91	disease	0.78	disease	0.72	disease	4	1	deleterious	0	neutral	5	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	2.04	high_impact	0.66	0.8	47.28	9.56	0.43	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8553	8553	C	G	MI.1844	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	188	63	S	W	tCa/tGa	7.53	1	0	probably_damaging	0.98	deleterious	0.02	neutral	1.29	deleterious	-6.27	deleterious	-4.32	medium_impact	3.44	1	neutral	0.38	neutral	4.64	24.50	deleterious	0.20969531	0.85	0.89	disease	0.37	neutral	0.69	disease	0.36	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-2.36	low_impact	-0.66	medium_impact	1.85	medium_impact	0.24	0.85	NA	NA	0.66	P	0.82	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11765	11765	C	A	MI.18440	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1006	336	R	S	Cgc/Agc	0.03	0.91	0	probably_damaging	1	deleterious	0.03	neutral	4.51	neutral	-1.89	deleterious	-5.66	medium_impact	2.92	0.46	damaging	0.35	neutral	4.82	24.80	deleterious	0.08	0.35	0.57	disease	0.9	disease	0.74	disease	0.73	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.87	deleterious	-3.54	low_impact	-0.64	medium_impact	1.76	medium_impact	0.26	0.8	47.28	9.56	0.43	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11765	11765	C	G	MI.18441	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1006	336	R	G	Cgc/Ggc	0.03	0.91	0	probably_damaging	1	deleterious	0.01	neutral	4.45	neutral	-2.3	deleterious	-6.59	high_impact	3.9	0.48	damaging	0.34	neutral	4.31	24.00	deleterious	0.07	0.35	0.56	disease	0.87	disease	0.76	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-0.92	medium_impact	2.73	high_impact	0.26	0.8	47.28	9.56	0.48	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11766	11766	G	C	MI.18442	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1007	336	R	P	cGc/cCc	3.48	1	0	probably_damaging	1	deleterious	0	neutral	4.43	deleterious	-3.91	deleterious	-6.62	high_impact	4.45	0.48	damaging	0.23	damaging	4.37	24.10	deleterious	0.04	0.35	0.82	disease	0.91	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.54	low_impact	-1.48	low_impact	3.28	high_impact	0.18	0.8	47.28	9.56	0.65	P	0.99	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11766	11766	G	T	MI.18443	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1007	336	R	L	cGc/cTc	3.48	1	0	probably_damaging	1	deleterious	0.04	neutral	4.43	deleterious	-3.05	deleterious	-6.62	medium_impact	3.12	0.51	damaging	0.29	neutral	4.46	24.20	deleterious	0.09	0.35	0.27	neutral	0.94	disease	0.75	disease	0.79	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-3.54	low_impact	-0.57	medium_impact	1.96	medium_impact	0.03	0.8	47.28	9.56	0.53	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11766	11766	G	A	MI.18444	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1007	336	R	H	cGc/cAc	3.48	1	0	probably_damaging	1	deleterious	0.01	neutral	4.42	deleterious	-3.32	deleterious	-4.72	high_impact	3.9	0.46	damaging	0.17	damaging	4.61	24.40	deleterious	0.22	0.45	0.8	disease	0.87	disease	0.73	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-0.92	medium_impact	2.73	high_impact	0.73	0.85	47.28	9.56	0.61	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11768	11768	A	G	MI.18445	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1009	337	T	A	Act/Gct	-20	0	0	possibly_damaging	0.7	neutral	0.19	neutral	4.61	neutral	-1.46	deleterious	-2.59	medium_impact	2.36	0.77	neutral	0.35	neutral	3.57	23.10	deleterious	0.31	0.45	0.4	neutral	0.51	disease	0.6	disease	0.56	disease	1	0.85	neutral	0.25	neutral	0	NA	0.71	deleterious	-1.06	low_impact	-0.15	medium_impact	1.21	medium_impact	0.24	0.8	11.76	13.38	0.35	N	0.27	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11768	11768	A	C	MI.18446	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1009	337	T	P	Act/Cct	-20	0	0	probably_damaging	0.98	neutral	0.08	neutral	4.55	deleterious	-4.33	deleterious	-4.01	high_impact	4.06	0.61	neutral	0.15	damaging	3.65	23.20	deleterious	0.03	0.35	0.65	disease	0.82	disease	0.6	disease	0.67	disease	3	0.99	deleterious	0.05	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	-0.39	medium_impact	2.89	high_impact	0.13	0.8	11.76	13.38	0.34	N	0.91	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11768	11768	A	T	MI.18447	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1009	337	T	S	Act/Tct	-20	0	0	possibly_damaging	0.88	neutral	0.63	neutral	4.7	neutral	-2	deleterious	-2.56	low_impact	1.75	0.71	neutral	0.29	neutral	3.46	23.00	deleterious	0.38	0.5	0.37	neutral	0.55	disease	0.33	neutral	0.38	neutral	3	0.86	neutral	0.38	neutral	-3	neutral	0.73	deleterious	-1.53	low_impact	0.33	medium_impact	0.61	medium_impact	0.28	0.8	11.76	13.38	0.28	N	0.32	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11769	11769	C	T	MI.18448	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1010	337	T	I	aCt/aTt	1.64	0	0	benign	0.08	neutral	0.33	neutral	4.61	neutral	-2.55	neutral	-1.34	low_impact	1.7	0.78	neutral	0.95	neutral	2.30	18.14	deleterious	0.16	0.45	0.44	neutral	0.55	disease	0.36	neutral	0.39	neutral	2	0.63	neutral	0.63	deleterious	-6	neutral	0.73	deleterious	0.28	medium_impact	0.03	medium_impact	0.56	medium_impact	0.36	0.8	11.76	13.38	0.41	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11769	11769	C	G	MI.18449	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1010	337	T	S	aCt/aGt	1.64	0	0	possibly_damaging	0.88	neutral	0.63	neutral	4.7	neutral	-2	deleterious	-2.56	low_impact	1.75	0.71	neutral	0.29	neutral	3.63	23.20	deleterious	0.38	0.5	0.37	neutral	0.55	disease	0.33	neutral	0.38	neutral	3	0.86	neutral	0.38	neutral	-3	neutral	0.73	deleterious	-1.53	low_impact	0.33	medium_impact	0.61	medium_impact	0.28	0.8	11.76	13.38	0.25	N	0.32	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8555	8555	T	G	MI.1845	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	190	64	L	V	Ttg/Gtg	-3.11	0	0	possibly_damaging	0.9	neutral	0.37	neutral	1.66	neutral	-2.2	neutral	-2.08	medium_impact	2.82	1	neutral	0.51	neutral	2.52	19.60	deleterious	0.75275300	0.85	0.55	disease	0.06	neutral	0.54	disease	0.05	neutral	9	0.9	neutral	0.24	neutral	0	NA	0.62	deleterious	-1.66	low_impact	0.16	medium_impact	1.32	medium_impact	0.61	0.85	2.94	7.63	0.5	N	0.44	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11769	11769	C	A	MI.18450	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1010	337	T	N	aCt/aAt	1.64	0	0	probably_damaging	0.97	neutral	0.16	neutral	4.63	deleterious	-3.22	deleterious	-3.54	medium_impact	2.91	0.69	neutral	0.2	damaging	3.70	23.30	deleterious	0.31	0.45	0.22	neutral	0.7	disease	0.5	neutral	0.47	neutral	1	0.98	deleterious	0.1	neutral	1	deleterious	0.70	deleterious	-2.14	low_impact	-0.2	medium_impact	1.75	medium_impact	0.31	0.8	11.76	13.38	0.37	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11771	11771	C	G	MI.18451	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1012	338	H	D	Cac/Gac	-7.57	0	0	probably_damaging	1	deleterious	0.04	neutral	4.6	neutral	-1.89	deleterious	-8.5	high_impact	3.74	0.67	neutral	0.11	damaging	4.00	23.60	deleterious	0.12	0.4	0.61	disease	0.88	disease	0.75	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-0.57	medium_impact	2.57	high_impact	0.19	0.8	46.19	9.25	0.39	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11771	11771	C	T	MI.18452	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1012	338	H	Y	Cac/Tac	-7.57	0	0	probably_damaging	1	neutral	0.25	neutral	4.57	deleterious	-3.92	deleterious	-5.67	medium_impact	2.85	0.7	neutral	0.11	damaging	3.89	23.50	deleterious	0.26	0.45	0.62	disease	0.86	disease	0.68	disease	0.64	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.07	medium_impact	1.69	medium_impact	0.23	0.8	46.19	9.25	0.25	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	COSM6716766	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11771	11771	C	A	MI.18453	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1012	338	H	N	Cac/Aac	-7.57	0	0	probably_damaging	1	neutral	0.25	neutral	4.68	neutral	-1.94	deleterious	-6.6	low_impact	1.15	0.72	neutral	0.3	neutral	4.05	23.70	deleterious	0.54	0.6	0.38	neutral	0.73	disease	0.53	disease	0.44	neutral	1	1	deleterious	0.13	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	-0.07	medium_impact	0.01	medium_impact	0.26	0.8	46.19	9.25	0.28	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11772	11772	A	T	MI.18454	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1013	338	H	L	cAc/cTc	4.17	0.99	0	probably_damaging	1	neutral	0.16	neutral	4.6	deleterious	-3.53	deleterious	-10.4	medium_impact	2.81	0.71	neutral	0.1	damaging	3.89	23.50	deleterious	0.09	0.35	0.3	neutral	0.9	disease	0.72	disease	0.68	disease	4	1	deleterious	0.08	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.2	medium_impact	1.65	medium_impact	0.17	0.8	46.19	9.25	0.45	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11772	11772	A	C	MI.18455	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1013	338	H	P	cAc/cCc	4.17	0.99	0	probably_damaging	1	deleterious	0.04	neutral	4.58	deleterious	-4.24	deleterious	-9.45	high_impact	3.74	0.72	neutral	0.11	damaging	3.35	22.90	deleterious	0.05	0.35	0.5	disease	0.92	disease	0.72	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-0.57	medium_impact	2.57	high_impact	0.18	0.8	46.19	9.25	0.56	P	0.95	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11772	11772	A	G	MI.18456	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1013	338	H	R	cAc/cGc	4.17	0.99	0	probably_damaging	1	neutral	0.09	neutral	4.65	neutral	-2.32	deleterious	-7.56	medium_impact	3.28	0.66	neutral	0.1	damaging	3.11	22.50	deleterious	0.32	0.5	0.55	disease	0.85	disease	0.7	disease	0.72	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.83	deleterious	-3.54	low_impact	-0.36	medium_impact	2.12	high_impact	0.33	0.8	46.19	9.25	0.5	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11773	11773	C	A	MI.18457	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1014	338	H	Q	caC/caA	6.7	1	0	probably_damaging	1	neutral	0.09	neutral	4.62	neutral	-2.51	deleterious	-7.56	medium_impact	2.52	0.7	neutral	0.11	damaging	4.06	23.70	deleterious	0.37	0.5	0.54	disease	0.8	disease	0.65	disease	0.53	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.36	medium_impact	1.37	medium_impact	0.25	0.8	46.19	9.25	0.51	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11773	11773	C	G	MI.18458	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1014	338	H	Q	caC/caG	6.7	1	0	probably_damaging	1	neutral	0.09	neutral	4.62	neutral	-2.51	deleterious	-7.56	medium_impact	2.52	0.7	neutral	0.11	damaging	3.68	23.30	deleterious	0.37	0.5	0.54	disease	0.8	disease	0.65	disease	0.53	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.36	medium_impact	1.37	medium_impact	0.25	0.8	46.19	9.25	0.51	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11774	11774	A	T	MI.18459	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1015	339	S	C	Agt/Tgt	-1.12	0.02	0	probably_damaging	0.99	deleterious	0	neutral	4.44	deleterious	-4.54	deleterious	-4.68	medium_impact	3.42	0.63	neutral	0.1	damaging	3.37	22.90	deleterious	0.16	0.45	0.89	disease	0.81	disease	0.57	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-2.59	low_impact	-1.48	low_impact	2.26	high_impact	0.15	0.8	45.32	9.05	0.28	N	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8555	8555	T	A	MI.1846	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	190	64	L	M	Ttg/Atg	-3.11	0	0	probably_damaging	0.98	neutral	0.1	neutral	1.61	deleterious	-3.63	neutral	-1.2	low_impact	1.12	0.99	neutral	0.63	neutral	2.70	20.80	deleterious	0.54328946	0.85	0.63	disease	0.06	neutral	0.35	neutral	0.05	neutral	9	0.99	deleterious	0.06	neutral	-2	neutral	0.67	deleterious	-2.36	low_impact	-0.25	medium_impact	-0.14	medium_impact	0.52	0.85	2.94	7.63	0.59	P	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11774	11774	A	G	MI.18460	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1015	339	S	G	Agt/Ggt	-1.12	0.02	0	possibly_damaging	0.73	deleterious	0	neutral	4.47	neutral	-1.7	deleterious	-3.69	high_impact	4.12	0.69	neutral	0.14	damaging	3.46	23.00	deleterious	0.39	0.5	0.58	disease	0.7	disease	0.67	disease	0.66	disease	3	1	deleterious	0.14	neutral	5	deleterious	0.74	deleterious	-1.12	low_impact	-1.48	low_impact	2.95	high_impact	0.36	0.8	45.32	9.05	0.41	N	0.87	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11774	11774	A	C	MI.18461	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1015	339	S	R	Agt/Cgt	-1.12	0.02	0	probably_damaging	0.96	deleterious	0	neutral	4.49	neutral	-1.99	deleterious	-4.59	high_impact	3.77	0.63	neutral	0.08	damaging	3.75	23.30	deleterious	0.1	0.4	0.54	disease	0.85	disease	0.72	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-2.01	low_impact	-1.48	low_impact	2.6	high_impact	0.33	0.8	45.32	9.05	0.36	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11775	11775	G	A	MI.18462	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1016	339	S	N	aGt/aAt	8.55	1	0	benign	0.17	deleterious	0	neutral	4.5	neutral	-1.75	deleterious	-2.57	medium_impact	3.02	0.71	neutral	0.28	neutral	2.56	19.82	deleterious	0.64	0.7	0.28	neutral	0.73	disease	0.43	neutral	0.36	neutral	3	1	deleterious	0.42	neutral	1	deleterious	0.72	deleterious	-0.07	medium_impact	-1.48	low_impact	1.86	medium_impact	0.53	0.8	45.32	9.05	0.58	P	0.91	polymorphism	1	0.10	.	.	.	.	.	.	COSM6716754	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11775	11775	G	T	MI.18463	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1016	339	S	I	aGt/aTt	8.55	1	0	probably_damaging	0.98	deleterious	0	neutral	4.49	deleterious	-3.11	deleterious	-5.59	high_impact	4.12	0.62	neutral	0.11	damaging	4.25	23.90	deleterious	0.13	0.4	0.74	disease	0.9	disease	0.66	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.31	low_impact	-1.48	low_impact	2.95	high_impact	0.23	0.8	45.32	9.05	0.6	P	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11775	11775	G	C	MI.18464	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1016	339	S	T	aGt/aCt	8.55	1	0	possibly_damaging	0.86	neutral	0.39	neutral	4.63	neutral	0.91	deleterious	-2.7	neutral_impact	0.36	0.71	neutral	0.32	neutral	3.48	23.10	deleterious	0.41	0.5	0.53	disease	0.38	neutral	0.27	neutral	0.38	neutral	2	0.86	neutral	0.27	neutral	-3	neutral	0.72	deleterious	-1.46	low_impact	0.09	medium_impact	-0.77	medium_impact	0.39	0.8	45.32	9.05	0.56	P	0.73	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11777	11777	C	G	MI.18465	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1018	340	R	G	Cgc/Ggc	0.49	0.99	0	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-3.83	deleterious	-6.64	high_impact	3.92	0.41	damaging	0.31	neutral	4.32	24.00	deleterious	0.06	0.35	0.6	disease	0.83	disease	0.8	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.75	high_impact	0.27	0.8	46.62	9.41	0.84	P	0.98	disease_causing_automatic	0	0.23	rs28384199	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	11777	11777	C	T	MI.18466	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1018	340	R	C	Cgc/Tgc	0.49	0.99	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-6.6	deleterious	-7.59	high_impact	4.61	0.42	damaging	0.14	damaging	5.19	25.50	deleterious	0.07	0.35	0.59	disease	0.89	disease	0.83	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.44	high_impact	0.77	0.85	46.62	9.41	0.71	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11777	11777	C	A	MI.18467	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1018	340	R	S	Cgc/Agc	0.49	0.99	0	probably_damaging	1	deleterious	0	neutral	4.52	neutral	-2.45	deleterious	-5.69	high_impact	4.05	0.44	damaging	0.32	neutral	4.69	24.60	deleterious	0.06	0.35	0.43	neutral	0.89	disease	0.79	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.88	high_impact	0.27	0.8	46.62	9.41	0.83	P	0.81	disease_causing_automatic	0	0.21	rs28384199	Pathogenic	Leigh_syndrome|Mitochondrial_complex_I_deficiency	24750	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838979,OMIM:252010	.	.	.	.	C11777A	Leigh Disease	-	+	Cfrm	11	P	P	P	damaging
chrM	11778	11778	G	T	MI.18468	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1019	340	R	L	cGc/cTc	4.4	1	0.08	probably_damaging	1	deleterious	0	neutral	4.45	deleterious	-3.21	deleterious	-6.64	high_impact	3.56	0.39	damaging	0.26	damaging	4.46	24.20	deleterious	0.06	0.35	0.5	neutral	0.92	disease	0.8	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.4	high_impact	0.02	0.8	46.62	9.41	0.81	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11778	11778	G	C	MI.18469	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1019	340	R	P	cGc/cCc	4.4	1	0.08	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-4.4	deleterious	-6.64	high_impact	4.61	0.4	damaging	0.2	damaging	4.35	24.10	deleterious	0.03	0.35	0.28	neutral	0.91	disease	0.87	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.44	high_impact	0.13	0.8	46.62	9.41	0.76	P	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8556	8556	T	C	MI.1847	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	191	64	L	S	tTg/tCg	-0.33	0	0	probably_damaging	0.96	neutral	0.13	neutral	1.71	neutral	-2.01	deleterious	-3.73	low_impact	1.29	1	neutral	0.85	neutral	4.02	23.60	deleterious	0.80602268	0.90	0.83	disease	0.16	neutral	0.32	neutral	0.12	neutral	8	0.98	deleterious	0.09	neutral	-2	neutral	0.73	deleterious	-2.07	low_impact	-0.18	medium_impact	0.01	medium_impact	0.45	0.85	2.94	7.63	0.56	P	0.40	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11778	11778	G	A	MI.18470	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1019	340	R	H	cGc/cAc	4.4	1	0.08	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-3.75	deleterious	-4.74	high_impact	4.61	0.18	damaging	0.13	damaging	4.56	24.40	deleterious	0.21	0.45	0.63	disease	0.87	disease	0.8	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.44	high_impact	0.77	0.85	46.62	9.41	0.97	P	1.00	disease_causing_automatic	0	0.24	rs199476112	Pathogenic	Leber's_optic_atrophy|not_specified|not_provided	24747	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:CN169374|MedGen:CN517202	.	.	.	.	G11778A	LHON / Progressive Dystonia	+	+	Cfrm	274	P	P	P	damaging
chrM	11780	11780	A	T	MI.18471	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1021	341	I	F	Atc/Ttc	-4.12	0	0	possibly_damaging	0.85	deleterious	0.02	neutral	4.62	neutral	-1.29	neutral	-1.06	medium_impact	2.65	0.71	neutral	0.49	neutral	2.35	18.48	deleterious	0.15	0.4	0.56	disease	0.61	disease	0.52	disease	0.59	disease	2	0.99	deleterious	0.09	neutral	4	deleterious	0.56	deleterious	-1.43	low_impact	-0.75	medium_impact	1.5	medium_impact	0.42	0.8	19.39	24.04	0.42	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11780	11780	A	G	MI.18472	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1021	341	I	V	Atc/Gtc	-4.12	0	0	benign	0.23	neutral	0.06	neutral	4.64	neutral	0.2	neutral	0.87	low_impact	1.68	0.75	neutral	0.76	neutral	1.35	12.55	neutral	0.52	0.6	0.34	neutral	0.27	neutral	0.39	neutral	0.43	neutral	1	0.93	neutral	0.42	neutral	-6	neutral	0.17	neutral	-0.23	medium_impact	-0.47	medium_impact	0.54	medium_impact	0.53	0.8	19.39	24.04	0.5	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11780	11780	A	C	MI.18473	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1021	341	I	L	Atc/Ctc	-4.12	0	0	benign	0.23	neutral	0.29	neutral	4.72	neutral	0.97	neutral	-0.08	neutral_impact	0.66	0.76	neutral	0.57	neutral	2.07	16.68	deleterious	0.34	0.5	0.33	neutral	0.39	neutral	0.47	neutral	0.45	neutral	1	0.65	neutral	0.53	deleterious	-6	neutral	0.21	neutral	-0.23	medium_impact	-0.02	medium_impact	-0.47	medium_impact	0.40	0.8	19.39	24.04	0.37	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11781	11781	T	C	MI.18474	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1022	341	I	T	aTc/aCc	5.55	0.99	0	benign	0.01	neutral	1	neutral	4.74	neutral	0.4	neutral	5.17	neutral_impact	-1.11	0.71	neutral	0.86	neutral	-1.10	0.01	neutral	0.21	0.45	0.26	neutral	0.09	neutral	0.17	neutral	0.28	neutral	4	0.01	neutral	1	deleterious	-6	neutral	0.12	neutral	1.16	medium_impact	1.88	high_impact	-2.22	low_impact	0.18	0.8	19.39	24.04	0.54	P	0.08	polymorphism	1	0.01	.	.	.	.	.	pancreatic cancer cell line, MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11781	11781	T	G	MI.18475	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1022	341	I	S	aTc/aGc	5.55	0.99	0	benign	0.32	neutral	1	neutral	4.75	neutral	1.09	neutral	1.57	neutral_impact	-0.12	0.76	neutral	0.76	neutral	2.55	19.81	deleterious	0.09	0.4	0.47	neutral	0.45	neutral	0.29	neutral	0.46	neutral	1	0.32	neutral	0.84	deleterious	-6	neutral	0.28	neutral	-0.41	medium_impact	1.88	high_impact	-1.25	low_impact	0.16	0.8	19.39	24.04	0.44	N	0.56	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11781	11781	T	A	MI.18476	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1022	341	I	N	aTc/aAc	5.55	0.99	0	possibly_damaging	0.57	neutral	0.26	neutral	4.76	neutral	1.09	neutral	0.6	neutral_impact	0.72	0.76	neutral	0.51	neutral	2.78	21.30	deleterious	0.22	0.45	0.28	neutral	0.73	disease	0.27	neutral	0.44	neutral	1	0.74	neutral	0.35	neutral	-3	neutral	0.49	deleterious	-0.83	medium_impact	-0.05	medium_impact	-0.41	medium_impact	0.08	0.8	19.39	24.04	0.56	P	0.56	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11782	11782	C	A	MI.18477	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1023	341	I	M	atC/atA	2.79	0.98	0	possibly_damaging	0.89	neutral	0.11	neutral	4.64	neutral	-0.7	neutral	-0.11	low_impact	1.26	0.75	neutral	0.69	neutral	3.69	23.30	deleterious	0.47	0.55	0.53	disease	0.4	neutral	0.33	neutral	0.4	neutral	2	0.96	neutral	0.11	neutral	-3	neutral	0.61	deleterious	-1.57	low_impact	-0.31	medium_impact	0.12	medium_impact	0.48	0.8	19.39	24.04	0.62	P	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11782	11782	C	G	MI.18478	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1023	341	I	M	atC/atG	2.79	0.98	0	possibly_damaging	0.89	neutral	0.11	neutral	4.64	neutral	-0.7	neutral	-0.11	low_impact	1.26	0.75	neutral	0.69	neutral	3.16	22.60	deleterious	0.47	0.55	0.53	disease	0.4	neutral	0.33	neutral	0.4	neutral	2	0.96	neutral	0.11	neutral	-3	neutral	0.61	deleterious	-1.57	low_impact	-0.31	medium_impact	0.12	medium_impact	0.48	0.8	19.39	24.04	0.62	P	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11783	11783	A	T	MI.18479	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1024	342	M	L	Ata/Tta	-8.95	0	0	probably_damaging	0.98	neutral	1	neutral	4.89	neutral	0.53	neutral	-2.1	neutral_impact	-0.34	0.71	neutral	0.66	neutral	1.88	15.48	deleterious	0.2	0.45	0.25	neutral	0.23	neutral	0.28	neutral	0.44	neutral	1	0.98	deleterious	0.51	deleterious	-2	neutral	0.53	deleterious	-2.31	low_impact	1.88	high_impact	-1.46	low_impact	0.39	0.8	25.93	8.72	0.26	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8556	8556	T	G	MI.1848	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	191	64	L	W	tTg/tGg	-0.33	0	0	probably_damaging	0.99	neutral	0.13	neutral	1.57	deleterious	-5.93	deleterious	-4.12	medium_impact	2.82	1	neutral	0.37	neutral	4.01	23.60	deleterious	0.44486802	0.85	0.92	disease	0.14	neutral	0.67	disease	0.23	neutral	5	0.99	deleterious	0.07	neutral	1	deleterious	0.74	deleterious	-2.65	low_impact	-0.18	medium_impact	1.32	medium_impact	0.45	0.85	2.94	7.63	0.55	N	0.81	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11783	11783	A	C	MI.18480	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1024	342	M	L	Ata/Cta	-8.95	0	0	probably_damaging	0.98	neutral	1	neutral	4.89	neutral	0.53	neutral	-2.1	neutral_impact	-0.34	0.71	neutral	0.66	neutral	1.81	15.07	deleterious	0.2	0.45	0.25	neutral	0.23	neutral	0.28	neutral	0.44	neutral	1	0.98	deleterious	0.51	deleterious	-2	neutral	0.53	deleterious	-2.31	low_impact	1.88	high_impact	-1.46	low_impact	0.39	0.8	25.93	8.72	0.26	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11783	11783	A	G	MI.18481	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1024	342	M	V	Ata/Gta	-8.95	0	0	probably_damaging	0.99	neutral	0.12	neutral	4.64	neutral	-0.99	deleterious	-3.35	low_impact	1.88	0.71	neutral	0.12	damaging	2.85	21.60	deleterious	0.2	0.45	0.39	neutral	0.73	disease	0.65	disease	0.68	disease	4	1	deleterious	0.07	neutral	-2	neutral	0.66	deleterious	-2.59	low_impact	-0.28	medium_impact	0.73	medium_impact	0.42	0.8	25.93	8.72	0.27	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11784	11784	T	C	MI.18482	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1025	342	M	T	aTa/aCa	0.95	0.3	0	probably_damaging	1	deleterious	0.03	neutral	4.61	neutral	-2.03	deleterious	-5.25	medium_impact	2.83	0.68	neutral	0.11	damaging	3.09	22.50	deleterious	0.05	0.35	0.45	neutral	0.78	disease	0.65	disease	0.7	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-0.64	medium_impact	1.67	medium_impact	0.13	0.8	25.93	8.72	0.29	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11784	11784	T	A	MI.18483	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1025	342	M	K	aTa/aAa	0.95	0.3	0	probably_damaging	1	deleterious	0	neutral	4.53	deleterious	-3.15	deleterious	-5.4	high_impact	3.63	0.66	neutral	0.09	damaging	4.10	23.70	deleterious	0.02	0.35	0.46	neutral	0.86	disease	0.73	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.47	high_impact	0.18	0.8	25.93	8.72	0.35	N	1.00	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11785	11785	A	C	MI.18484	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1026	342	M	I	atA/atC	7.4	0.97	0	probably_damaging	0.99	neutral	0.33	neutral	4.85	neutral	0.83	deleterious	-3.2	low_impact	1.23	0.71	neutral	0.2	damaging	3.52	23.10	deleterious	0.21	0.45	0.44	neutral	0.7	disease	0.42	neutral	0.36	neutral	3	0.99	deleterious	0.17	neutral	-2	neutral	0.72	deleterious	-2.59	low_impact	0.03	medium_impact	0.09	medium_impact	0.50	0.8	25.93	8.72	0.51	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11785	11785	A	T	MI.18485	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1026	342	M	I	atA/atT	7.4	0.97	0	probably_damaging	0.99	neutral	0.33	neutral	4.85	neutral	0.83	deleterious	-3.2	low_impact	1.23	0.71	neutral	0.2	damaging	3.57	23.20	deleterious	0.21	0.45	0.44	neutral	0.7	disease	0.42	neutral	0.36	neutral	3	0.99	deleterious	0.17	neutral	-2	neutral	0.72	deleterious	-2.59	low_impact	0.03	medium_impact	0.09	medium_impact	0.50	0.8	25.93	8.72	0.53	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11786	11786	A	T	MI.18486	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1027	343	I	F	Atc/Ttc	0.26	0.01	0	benign	0.37	neutral	0.41	neutral	4.66	neutral	-1.79	deleterious	-2.62	low_impact	1.18	0.8	neutral	0.72	neutral	3.87	23.50	deleterious	0.13	0.4	0.71	disease	0.48	neutral	0.24	neutral	0.56	disease	1	0.52	neutral	0.52	deleterious	-6	neutral	0.76	deleterious	-0.5	medium_impact	0.11	medium_impact	0.04	medium_impact	0.40	0.8	27.45	26.1	0.31	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11786	11786	A	G	MI.18487	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1027	343	I	V	Atc/Gtc	0.26	0.01	0	benign	0.13	neutral	0.23	neutral	4.68	neutral	-0.73	neutral	-0.7	low_impact	1.05	0.75	neutral	0.84	neutral	1.80	15.00	deleterious	0.43	0.55	0.51	disease	0.17	neutral	0.22	neutral	0.27	neutral	5	0.73	neutral	0.55	deleterious	-6	neutral	0.62	deleterious	0.06	medium_impact	-0.09	medium_impact	-0.09	medium_impact	0.43	0.8	27.45	26.1	0.51	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11786	11786	A	C	MI.18488	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1027	343	I	L	Atc/Ctc	0.26	0.01	0	benign	0.01	neutral	1	neutral	4.7	neutral	-0.81	neutral	-0.25	neutral_impact	0.21	0.75	neutral	0.95	neutral	1.47	13.16	neutral	0.29	0.45	0.45	neutral	0.13	neutral	0.12	neutral	0.27	neutral	5	0.01	neutral	1	deleterious	-6	neutral	0.62	deleterious	1.16	medium_impact	1.88	high_impact	-0.92	medium_impact	0.27	0.8	27.45	26.1	0.36	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11787	11787	T	G	MI.18489	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1028	343	I	S	aTc/aGc	-2.73	0	0	benign	0.27	neutral	0.1	neutral	4.67	neutral	0.92	deleterious	-4.33	low_impact	1.8	0.74	neutral	0.42	neutral	4.43	24.20	deleterious	0.11	0.4	0.63	disease	0.65	disease	0.44	neutral	0.46	neutral	1	0.88	neutral	0.42	neutral	-6	neutral	0.78	deleterious	-0.31	medium_impact	-0.33	medium_impact	0.66	medium_impact	0.16	0.8	27.45	26.1	0.34	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8557	8557	G	C	MI.1849	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	192	64	L	F	ttG/ttC	-0.8	0	0.02	probably_damaging	0.96	neutral	0.24	neutral	1.61	deleterious	-3.53	deleterious	-2.82	medium_impact	2.82	0.98	neutral	0.47	neutral	3.20	22.70	deleterious	0.76071314	0.85	0.66	disease	0.08	neutral	0.65	disease	0.15	neutral	7	0.97	neutral	0.14	neutral	1	deleterious	0.67	deleterious	-2.07	low_impact	0.01	medium_impact	1.32	medium_impact	0.44	0.85	2.94	7.63	0.53	P	0.57	polymorphism	1	0.17	rs386829040	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11787	11787	T	C	MI.18490	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1028	343	I	T	aTc/aCc	-2.73	0	0	benign	0.27	deleterious	0.04	neutral	4.69	neutral	0.25	deleterious	-3.39	low_impact	1.02	0.8	neutral	0.7	neutral	3.57	23.10	deleterious	0.17	0.45	0.35	neutral	0.42	neutral	0.26	neutral	0.48	neutral	0	0.95	neutral	0.39	neutral	-2	neutral	0.68	deleterious	-0.31	medium_impact	-0.57	medium_impact	-0.12	medium_impact	0.20	0.8	27.45	26.1	0.38	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11787	11787	T	A	MI.18491	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1028	343	I	N	aTc/aAc	-2.73	0	0	possibly_damaging	0.73	deleterious	0.02	neutral	4.63	neutral	0.25	deleterious	-5.29	medium_impact	2	0.73	neutral	0.42	neutral	4.77	24.70	deleterious	0.19	0.45	0.82	disease	0.7	disease	0.51	disease	0.61	disease	2	0.98	deleterious	0.15	neutral	4	deleterious	0.82	deleterious	-1.12	low_impact	-0.75	medium_impact	0.85	medium_impact	0.13	0.8	27.45	26.1	0.29	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11788	11788	C	G	MI.18492	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1029	343	I	M	atC/atG	7.4	0.95	0	benign	0.03	neutral	0.24	neutral	4.63	neutral	-1.9	neutral	-1.04	neutral_impact	0.69	0.75	neutral	0.91	neutral	2.26	17.93	deleterious	0.42	0.55	0.56	disease	0.3	neutral	0.18	neutral	0.59	disease	2	0.75	neutral	0.61	deleterious	-6	neutral	0.71	deleterious	0.7	medium_impact	-0.08	medium_impact	-0.44	medium_impact	0.39	0.8	27.45	26.1	0.58	P	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11788	11788	C	A	MI.18493	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1029	343	I	M	atC/atA	7.4	0.95	0	benign	0.03	neutral	0.24	neutral	4.63	neutral	-1.9	neutral	-1.04	neutral_impact	0.69	0.75	neutral	0.91	neutral	2.73	21.00	deleterious	0.42	0.55	0.56	disease	0.3	neutral	0.18	neutral	0.59	disease	2	0.75	neutral	0.61	deleterious	-6	neutral	0.71	deleterious	0.7	medium_impact	-0.08	medium_impact	-0.44	medium_impact	0.39	0.8	27.45	26.1	0.58	P	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11789	11789	C	G	MI.18494	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1030	344	L	V	Ctc/Gtc	-20	0	0	possibly_damaging	0.74	neutral	0.19	neutral	4.61	neutral	-1.77	deleterious	-2.66	medium_impact	2.09	0.72	neutral	0.51	neutral	3.57	23.20	deleterious	0.43	0.55	0.38	neutral	0.48	neutral	0.41	neutral	0.45	neutral	1	0.86	neutral	0.23	neutral	0	NA	0.72	deleterious	-1.14	low_impact	-0.15	medium_impact	0.94	medium_impact	0.23	0.8	24.4	23.16	0.43	N	0.46	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11789	11789	C	T	MI.18495	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1030	344	L	F	Ctc/Ttc	-20	0	0	benign	0.12	neutral	0.13	neutral	4.57	neutral	-2.04	deleterious	-3.14	medium_impact	2.28	0.69	neutral	0.65	neutral	4.08	23.70	deleterious	0.41	0.5	0.62	disease	0.53	disease	0.44	neutral	0.44	neutral	1	0.85	neutral	0.51	deleterious	-3	neutral	0.77	deleterious	0.1	medium_impact	-0.26	medium_impact	1.13	medium_impact	0.29	0.8	24.4	23.16	0.42	N	0.73	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11789	11789	C	A	MI.18496	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1030	344	L	I	Ctc/Atc	-20	0	0	possibly_damaging	0.74	neutral	0.39	neutral	4.67	neutral	-2.2	neutral	-1.74	low_impact	1.68	0.79	neutral	0.62	neutral	4.21	23.90	deleterious	0.45	0.55	0.4	neutral	0.31	neutral	0.2	neutral	0.45	neutral	1	0.76	neutral	0.33	neutral	-3	neutral	0.71	deleterious	-1.14	low_impact	0.09	medium_impact	0.54	medium_impact	0.17	0.8	24.4	23.16	0.41	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11790	11790	T	G	MI.18497	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1031	344	L	R	cTc/cGc	-1.58	0	0	probably_damaging	0.97	deleterious	0.01	neutral	4.61	neutral	0.32	deleterious	-5.42	medium_impact	3.17	0.63	neutral	0.4	neutral	4.34	24.00	deleterious	0.1	0.4	0.63	disease	0.81	disease	0.67	disease	0.68	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-2.14	low_impact	-0.92	medium_impact	2.01	high_impact	0.15	0.8	24.4	23.16	0.33	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11790	11790	T	C	MI.18498	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1031	344	L	P	cTc/cCc	-1.58	0	0	probably_damaging	0.98	deleterious	0	neutral	4.56	neutral	-2.61	deleterious	-6.37	high_impact	3.73	0.62	neutral	0.44	neutral	4.02	23.60	deleterious	0.05	0.35	0.24	neutral	0.81	disease	0.7	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.31	low_impact	-1.48	low_impact	2.56	high_impact	0.13	0.8	24.4	23.16	0.38	N	0.87	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11790	11790	T	A	MI.18499	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1031	344	L	H	cTc/cAc	-1.58	0	0	probably_damaging	0.98	deleterious	0.03	neutral	4.58	neutral	-1.9	deleterious	-6.19	medium_impact	3.27	0.72	neutral	0.43	neutral	4.26	23.90	deleterious	0.12	0.4	0.74	disease	0.77	disease	0.65	disease	0.68	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.82	deleterious	-2.31	low_impact	-0.64	medium_impact	2.11	high_impact	0.07	0.8	24.4	23.16	0.34	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8612	8612	T	C	MI.185	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	86	29	L	P	cTa/cCa	-2.42	0	0	probably_damaging	1	neutral	0.05	neutral	4.26	deleterious	-3.7	deleterious	-4.91	medium_impact	3.19	0.75	neutral	0.15	damaging	3.62	23.20	deleterious	0.21	0.65	0.81	disease	0.78	disease	0.67	disease	0.74	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	-0.43	medium_impact	1.64	medium_impact	0.55	0.9	17.26	17.02	0.31	N	0.91	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8557	8557	G	T	MI.1850	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	192	64	L	F	ttG/ttT	-0.8	0	0.02	probably_damaging	0.96	neutral	0.24	neutral	1.61	deleterious	-3.53	deleterious	-2.82	medium_impact	2.82	0.98	neutral	0.47	neutral	2.73	21.00	deleterious	0.76071314	0.85	0.66	disease	0.08	neutral	0.65	disease	0.15	neutral	7	0.97	neutral	0.14	neutral	1	deleterious	0.67	deleterious	-2.07	low_impact	0.01	medium_impact	1.32	medium_impact	0.44	0.85	2.94	7.63	0.53	P	0.57	polymorphism	1	0.17	rs386829040	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11792	11792	T	A	MI.18500	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1033	345	S	T	Tct/Act	-2.04	0	0	benign	0.04	neutral	0.41	neutral	4.69	neutral	-0.21	neutral	-0.1	neutral_impact	-1	0.72	neutral	0.95	neutral	2.53	19.65	deleterious	0.3	0.45	0.39	neutral	0.09	neutral	0.13	neutral	0.26	neutral	5	0.56	neutral	0.69	deleterious	-6	neutral	0.67	deleterious	0.58	medium_impact	0.11	medium_impact	-2.12	low_impact	0.49	0.8	25.93	33.18	0.52	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11792	11792	T	G	MI.18501	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1033	345	S	A	Tct/Gct	-2.04	0	0	benign	0.01	neutral	0.55	neutral	4.67	neutral	0.44	neutral	1.77	neutral_impact	-0.59	0.66	neutral	0.92	neutral	1.09	11.14	neutral	0.31	0.45	0.27	neutral	0.05	neutral	0.14	neutral	0.22	neutral	6	0.43	neutral	0.77	deleterious	-6	neutral	0.65	deleterious	1.16	medium_impact	0.25	medium_impact	-1.71	low_impact	0.42	0.8	25.93	33.18	0.45	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11792	11792	T	C	MI.18502	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1033	345	S	P	Tct/Cct	-2.04	0	0	benign	0.03	neutral	0.2	neutral	4.61	neutral	-1.63	neutral	-1.95	medium_impact	2.19	0.71	neutral	0.46	neutral	4.09	23.70	deleterious	0.11	0.4	0.74	disease	0.79	disease	0.65	disease	0.75	disease	5	0.79	neutral	0.59	deleterious	-3	neutral	0.87	deleterious	0.7	medium_impact	-0.14	medium_impact	1.04	medium_impact	0.33	0.8	25.93	33.18	0.32	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11793	11793	C	T	MI.18503	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1034	345	S	F	tCt/tTt	0.49	0	0	possibly_damaging	0.9	neutral	0.69	neutral	4.67	neutral	1.15	deleterious	-2.7	neutral_impact	0.66	0.66	neutral	0.57	neutral	4.32	24.00	deleterious	0.08	0.35	0.41	neutral	0.56	disease	0.56	disease	0.68	disease	4	0.89	neutral	0.4	neutral	-3	neutral	0.74	deleterious	-1.61	low_impact	0.4	medium_impact	-0.47	medium_impact	0.06	0.8	25.93	33.18	0.28	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11793	11793	C	G	MI.18504	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1034	345	S	C	tCt/tGt	0.49	0	0	probably_damaging	0.93	neutral	0.18	neutral	4.61	neutral	-1.82	neutral	-1.19	low_impact	0.8	0.65	neutral	0.42	neutral	3.72	23.30	deleterious	0.1	0.4	0.76	disease	0.52	disease	0.49	neutral	0.51	disease	0	0.96	neutral	0.13	neutral	-2	neutral	0.76	deleterious	-1.77	low_impact	-0.17	medium_impact	-0.33	medium_impact	0.24	0.8	25.93	33.18	0.39	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11793	11793	C	A	MI.18505	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1034	345	S	Y	tCt/tAt	0.49	0	0	probably_damaging	0.93	neutral	1	neutral	4.87	neutral	1.61	deleterious	-2.74	neutral_impact	0.22	0.72	neutral	0.62	neutral	4.11	23.70	deleterious	0.09	0.35	0.65	disease	0.54	disease	0.56	disease	0.68	disease	4	0.93	neutral	0.54	deleterious	-2	neutral	0.78	deleterious	-1.77	low_impact	1.88	high_impact	-0.91	medium_impact	0.15	0.8	25.93	33.18	0.26	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11795	11795	C	G	MI.18506	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1036	346	Q	E	Caa/Gaa	-14.94	0	0	benign	0.05	deleterious	0.01	neutral	4.72	neutral	0.26	neutral	-1.02	medium_impact	2.42	0.68	neutral	0.51	neutral	1.33	12.43	neutral	0.47	0.55	0.53	disease	0.63	disease	0.61	disease	0.7	disease	4	0.99	deleterious	0.48	deleterious	1	deleterious	0.26	neutral	0.48	medium_impact	-0.92	medium_impact	1.27	medium_impact	0.28	0.8	41.83	8.78	0.37	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11795	11795	C	A	MI.18507	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1036	346	Q	K	Caa/Aaa	-14.94	0	0	benign	0.02	neutral	0.88	neutral	4.72	neutral	0.88	neutral	0.77	neutral_impact	-0.36	0.67	neutral	0.53	neutral	2.22	17.62	deleterious	0.45	0.55	0.5	neutral	0.43	neutral	0.36	neutral	0.35	neutral	3	0.07	neutral	0.93	deleterious	-6	neutral	0.22	neutral	0.87	medium_impact	0.69	medium_impact	-1.48	low_impact	0.33	0.8	41.83	8.78	0.28	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11796	11796	A	T	MI.18508	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1037	346	Q	L	cAa/cTa	4.4	0.99	0	benign	0.11	deleterious	0	neutral	4.61	neutral	-1.38	deleterious	-2.99	medium_impact	2.42	0.72	neutral	0.54	neutral	2.08	16.73	deleterious	0.16	0.45	0.51	disease	0.63	disease	0.55	disease	0.68	disease	4	1	deleterious	0.45	neutral	1	deleterious	0.30	neutral	0.14	medium_impact	-1.48	low_impact	1.27	medium_impact	0.28	0.8	41.83	8.78	0.56	P	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11796	11796	A	G	MI.18509	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1037	346	Q	R	cAa/cGa	4.4	0.99	0	benign	0	neutral	1	neutral	4.72	neutral	1.07	neutral	3.51	neutral_impact	-1.49	0.78	neutral	0.89	neutral	-1.05	0.01	neutral	0.55	0.6	0.23	neutral	0.13	neutral	0.25	neutral	0.25	neutral	5	0	neutral	1	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	1.88	high_impact	-2.6	low_impact	0.17	0.8	41.83	8.78	0.45	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8558	8558	C	A	MI.1851	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	193	65	P	T	Ccc/Acc	1.05	0.01	0	probably_damaging	0.98	neutral	0.4	neutral	1.44	deleterious	-4.86	deleterious	-5.15	medium_impact	2.54	0.98	neutral	0.43	neutral	3.94	23.50	deleterious	0.67403744	0.85	0.55	disease	0.11	neutral	0.56	disease	0.19	neutral	6	0.98	deleterious	0.21	neutral	1	deleterious	0.72	deleterious	-2.36	low_impact	0.19	medium_impact	1.08	medium_impact	0.56	0.85	NA	NA	0.51	N	0.69	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11796	11796	A	C	MI.18510	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1037	346	Q	P	cAa/cCa	4.4	0.99	0	benign	0.36	deleterious	0	neutral	4.6	neutral	-1.92	deleterious	-2.95	medium_impact	2.42	0.61	neutral	0.35	neutral	1.75	14.67	neutral	0.08	0.35	0.26	neutral	0.84	disease	0.73	disease	0.75	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.49	deleterious	-0.48	medium_impact	-1.48	low_impact	1.27	medium_impact	0.30	0.8	41.83	8.78	0.46	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11797	11797	A	C	MI.18511	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1038	346	Q	H	caA/caC	2.79	1	0	possibly_damaging	0.49	deleterious	0	neutral	4.6	neutral	-1.33	neutral	-1.09	low_impact	1.62	0.72	neutral	0.55	neutral	1.92	15.74	deleterious	0.37	0.5	0.63	disease	0.47	neutral	0.51	disease	0.59	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.59	deleterious	-0.7	medium_impact	-1.48	low_impact	0.48	medium_impact	0.43	0.8	41.83	8.78	0.58	P	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11797	11797	A	T	MI.18512	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1038	346	Q	H	caA/caT	2.79	1	0	possibly_damaging	0.49	deleterious	0	neutral	4.6	neutral	-1.33	neutral	-1.09	low_impact	1.62	0.72	neutral	0.55	neutral	2.05	16.54	deleterious	0.37	0.5	0.63	disease	0.47	neutral	0.51	disease	0.59	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.59	deleterious	-0.7	medium_impact	-1.48	low_impact	0.48	medium_impact	0.43	0.8	41.83	8.78	0.57	P	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11798	11798	G	C	MI.18513	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1039	347	G	R	Gga/Cga	0.26	0.97	0	probably_damaging	1	deleterious	0	neutral	4.39	deleterious	-6.06	deleterious	-7.58	high_impact	4.24	0.72	neutral	0.1	damaging	4.08	23.70	deleterious	0.04	0.35	0.95	disease	0.87	disease	0.84	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.07	high_impact	0.65	0.8	47.06	9.29	0.5	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11798	11798	G	T	MI.18514	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1039	347	G	W	Gga/Tga	0.26	0.97	0	probably_damaging	1	deleterious	0	neutral	4.3	deleterious	-9.61	deleterious	-7.58	high_impact	4.59	0.72	neutral	0.11	damaging	4.55	24.40	deleterious	0.05	0.35	0.99	disease	0.88	disease	0.81	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.10	0.8	47.06	9.29	0.53	N	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11799	11799	G	C	MI.18515	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1040	347	G	A	gGa/gCa	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.39	deleterious	-5.04	deleterious	-5.68	high_impact	4.04	0.72	neutral	0.16	damaging	3.18	22.70	deleterious	0.08	0.35	0.88	disease	0.65	disease	0.72	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.42	0.8	47.06	9.29	0.63	P	0.76	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11799	11799	G	A	MI.18516	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1040	347	G	E	gGa/gAa	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.39	deleterious	-5.5	deleterious	-7.58	high_impact	4.59	0.72	neutral	0.12	damaging	4.05	23.70	deleterious	0.04	0.35	0.71	disease	0.85	disease	0.82	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.24	0.8	47.06	9.29	0.66	P	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11799	11799	G	T	MI.18517	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1040	347	G	V	gGa/gTa	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.33	deleterious	-6.36	deleterious	-8.53	high_impact	4.59	0.69	neutral	0.12	damaging	3.90	23.50	deleterious	0.03	0.35	0.96	disease	0.86	disease	0.75	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.42	high_impact	0.10	0.8	47.06	9.29	0.61	P	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11801	11801	C	T	MI.18518	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1042	348	L	F	Ctt/Ttt	-9.41	0	0	probably_damaging	1	neutral	0.17	neutral	4.23	deleterious	-5.05	deleterious	-3.42	medium_impact	2.31	0.71	neutral	0.28	neutral	4.11	23.80	deleterious	0.16	0.45	0.75	disease	0.5	disease	0.33	neutral	0.5	disease	0	1	deleterious	0.09	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.18	medium_impact	1.16	medium_impact	0.28	0.8	45.32	8.56	0.3	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11801	11801	C	G	MI.18519	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1042	348	L	V	Ctt/Gtt	-9.41	0	0	probably_damaging	1	neutral	0.13	neutral	4.25	deleterious	-3.13	neutral	-2.39	medium_impact	2.41	0.71	neutral	0.19	damaging	3.58	23.20	deleterious	0.23	0.45	0.71	disease	0.55	disease	0.63	disease	0.57	disease	1	1	deleterious	0.07	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.26	medium_impact	1.26	medium_impact	0.28	0.8	45.32	8.56	0.27	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8558	8558	C	T	MI.1852	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	193	65	P	S	Ccc/Tcc	1.05	0.01	0	probably_damaging	0.98	neutral	0.4	neutral	1.48	deleterious	-4.44	deleterious	-5.12	low_impact	1.54	0.99	neutral	0.67	neutral	4.14	23.80	deleterious	0.58173615	0.85	0.36	neutral	0.1	neutral	0.35	neutral	0.07	neutral	9	0.98	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-2.36	low_impact	0.19	medium_impact	0.22	medium_impact	0.28	0.85	NA	NA	0.6	P	0.61	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	C8558T	Possibly LVNC cardiomyopathy-associated	+	-	Reported	1	.	P	P	neutral
chrM	11801	11801	C	A	MI.18520	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1042	348	L	I	Ctt/Att	-9.41	0	0	probably_damaging	1	neutral	0.05	neutral	4.23	deleterious	-3.13	neutral	-1.61	medium_impact	2.4	0.71	neutral	0.23	damaging	4.24	23.90	deleterious	0.31	0.45	0.49	neutral	0.59	disease	0.43	neutral	0.49	neutral	0	1	deleterious	0.03	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.52	medium_impact	1.25	medium_impact	0.51	0.8	45.32	8.56	0.33	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11802	11802	T	C	MI.18521	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1043	348	L	P	cTt/cCt	-1.12	0	0	probably_damaging	1	deleterious	0	neutral	4.13	deleterious	-6.56	deleterious	-6.01	high_impact	4.25	0.59	damaging	0.12	damaging	4.12	23.80	deleterious	0.03	0.35	0.96	disease	0.86	disease	0.77	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.20	0.8	45.32	8.56	0.41	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11802	11802	T	A	MI.18522	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1043	348	L	H	cTt/cAt	-1.12	0	0	probably_damaging	1	deleterious	0	neutral	4.13	deleterious	-6.97	deleterious	-6.05	high_impact	4.25	0.65	neutral	0.11	damaging	4.44	24.20	deleterious	0.05	0.35	0.96	disease	0.8	disease	0.73	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.22	0.8	45.32	8.56	0.36	N	0.96	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11802	11802	T	G	MI.18523	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1043	348	L	R	cTt/cGt	-1.12	0	0	probably_damaging	1	deleterious	0	neutral	4.14	deleterious	-6.17	deleterious	-5.14	high_impact	4.25	0.62	neutral	0.11	damaging	4.42	24.20	deleterious	0.02	0.35	0.94	disease	0.88	disease	0.77	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.54	low_impact	-1.48	low_impact	3.08	high_impact	0.15	0.8	45.32	8.56	0.42	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11804	11804	C	A	MI.18524	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1045	349	Q	K	Caa/Aaa	-5.5	0	0	probably_damaging	1	neutral	0.97	neutral	4.65	neutral	0.2	deleterious	-3.72	medium_impact	2.44	0.7	neutral	0.14	damaging	4.07	23.70	deleterious	0.28	0.45	0.32	neutral	0.83	disease	0.37	neutral	0.51	disease	0	1	deleterious	0.49	deleterious	1	deleterious	0.75	deleterious	-3.54	low_impact	1.05	medium_impact	1.29	medium_impact	0.30	0.8	47.93	9.07	0.21	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11804	11804	C	G	MI.18525	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1045	349	Q	E	Caa/Gaa	-5.5	0	0	probably_damaging	1	neutral	1	neutral	4.63	neutral	-0.63	deleterious	-2.81	medium_impact	2.78	0.71	neutral	0.15	damaging	3.22	22.70	deleterious	0.47	0.55	0.32	neutral	0.78	disease	0.6	disease	0.66	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.73	deleterious	-3.54	low_impact	1.88	high_impact	1.62	medium_impact	0.45	0.8	47.93	9.07	0.21	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11805	11805	A	T	MI.18526	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1046	349	Q	L	cAa/cTa	5.32	1	0	probably_damaging	1	neutral	0.74	neutral	4.8	neutral	2.36	deleterious	-6.41	low_impact	1.34	0.73	neutral	0.15	damaging	3.98	23.60	deleterious	0.11	0.4	0.26	neutral	0.8	disease	0.45	neutral	0.5	disease	0	1	deleterious	0.37	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	0.46	medium_impact	0.2	medium_impact	0.09	0.8	47.93	9.07	0.41	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11805	11805	A	G	MI.18527	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1046	349	Q	R	cAa/cGa	5.32	1	0	probably_damaging	1	neutral	0.65	neutral	4.7	neutral	1.26	deleterious	-3.72	medium_impact	3.08	0.65	neutral	0.15	damaging	3.58	23.20	deleterious	0.25	0.45	0.47	neutral	0.88	disease	0.62	disease	0.71	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	0.35	medium_impact	1.92	medium_impact	0.12	0.8	47.93	9.07	0.51	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11805	11805	A	C	MI.18528	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1046	349	Q	P	cAa/cCa	5.32	1	0	probably_damaging	1	neutral	0.36	neutral	4.62	neutral	-1.28	deleterious	-5.6	high_impact	3.53	0.63	neutral	0.14	damaging	3.47	23.00	deleterious	0.07	0.35	0.63	disease	0.91	disease	0.7	disease	0.77	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.54	low_impact	0.06	medium_impact	2.37	high_impact	0.31	0.8	47.93	9.07	0.6	P	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11806	11806	A	C	MI.18529	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1047	349	Q	H	caA/caC	6.7	1	0	probably_damaging	1	neutral	0.46	neutral	4.62	neutral	-1.2	deleterious	-4.64	medium_impact	1.99	0.76	neutral	0.26	damaging	3.54	23.10	deleterious	0.35	0.5	0.61	disease	0.75	disease	0.35	neutral	0.53	disease	1	1	deleterious	0.23	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.16	medium_impact	0.84	medium_impact	0.42	0.8	47.93	9.07	0.53	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8558	8558	C	G	MI.1853	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	193	65	P	A	Ccc/Gcc	1.05	0.01	0	probably_damaging	0.97	neutral	0.52	neutral	1.48	deleterious	-4.18	deleterious	-5.16	medium_impact	2.89	0.99	neutral	0.48	neutral	3.33	22.90	deleterious	0.54328946	0.85	0.43	neutral	0.05	neutral	0.55	disease	0.15	neutral	7	0.96	neutral	0.28	neutral	1	deleterious	0.70	deleterious	-2.19	low_impact	0.31	medium_impact	1.38	medium_impact	0.72	0.85	NA	NA	0.52	N	0.63	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11806	11806	A	T	MI.18530	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1047	349	Q	H	caA/caT	6.7	1	0	probably_damaging	1	neutral	0.46	neutral	4.62	neutral	-1.2	deleterious	-4.64	medium_impact	1.99	0.76	neutral	0.26	damaging	3.69	23.30	deleterious	0.35	0.5	0.61	disease	0.75	disease	0.35	neutral	0.53	disease	1	1	deleterious	0.23	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	0.16	medium_impact	0.84	medium_impact	0.42	0.8	47.93	9.07	0.53	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11807	11807	A	G	MI.18531	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1048	350	T	A	Act/Gct	1.64	0.86	0	benign	0	neutral	0.85	neutral	4.66	neutral	0.07	neutral	-1.87	low_impact	1.1	0.71	neutral	0.85	neutral	0.11	3.73	deleterious	0.44	0.55	0.3	neutral	0.35	neutral	0.33	neutral	0.44	neutral	1	0.14	neutral	0.93	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.62	medium_impact	-0.04	medium_impact	0.15	0.8	18.95	14.76	0.34	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11807	11807	A	T	MI.18532	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1048	350	T	S	Act/Tct	1.64	0.86	0	benign	0.01	neutral	0.77	neutral	4.63	neutral	0.52	neutral	-1.62	neutral_impact	0.58	0.76	neutral	0.94	neutral	0.14	4.00	deleterious	0.56	0.6	0.4	neutral	0.3	neutral	0.19	neutral	0.46	neutral	1	0.21	neutral	0.88	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.5	medium_impact	-0.55	medium_impact	0.61	0.8	18.95	14.76	0.32	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11807	11807	A	C	MI.18533	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1048	350	T	P	Act/Cct	1.64	0.86	0	benign	0.36	neutral	0.34	neutral	4.6	neutral	-1.64	deleterious	-3.31	low_impact	1.81	0.71	neutral	0.66	neutral	1.69	14.33	neutral	0.05	0.35	0.66	disease	0.74	disease	0.53	disease	0.56	disease	1	0.6	neutral	0.49	deleterious	-6	neutral	0.37	neutral	-0.48	medium_impact	0.04	medium_impact	0.67	medium_impact	0.20	0.8	18.95	14.76	0.32	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11808	11808	C	A	MI.18534	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1049	350	T	N	aCt/aAt	0.95	0.32	0	benign	0.23	neutral	0.69	neutral	4.71	neutral	-0.18	deleterious	-2.84	neutral_impact	0.66	0.76	neutral	0.74	neutral	2.06	16.62	deleterious	0.5	0.6	0.73	disease	0.43	neutral	0.2	neutral	0.62	disease	2	0.2	neutral	0.73	deleterious	-6	neutral	0.36	neutral	-0.23	medium_impact	0.4	medium_impact	-0.47	medium_impact	0.46	0.8	18.95	14.76	0.24	N	0.68	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11808	11808	C	G	MI.18535	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1049	350	T	S	aCt/aGt	0.95	0.32	0	benign	0.01	neutral	0.77	neutral	4.63	neutral	0.52	neutral	-1.62	neutral_impact	0.58	0.76	neutral	0.94	neutral	0.49	7.36	deleterious	0.56	0.6	0.4	neutral	0.3	neutral	0.19	neutral	0.46	neutral	1	0.21	neutral	0.88	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.5	medium_impact	-0.55	medium_impact	0.61	0.8	18.95	14.76	0.33	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11808	11808	C	T	MI.18536	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1049	350	T	I	aCt/aTt	0.95	0.32	0	benign	0	neutral	0.51	neutral	4.63	neutral	-1.81	neutral	-1.58	low_impact	1.17	0.72	neutral	0.99	neutral	0.45	7.03	deleterious	0.2	0.45	0.27	neutral	0.56	disease	0.2	neutral	0.42	neutral	2	0.48	neutral	0.76	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	0.21	medium_impact	0.03	medium_impact	0.35	0.8	18.95	14.76	0.42	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11810	11810	C	G	MI.18537	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1051	351	L	V	Cta/Gta	-9.64	0	0.01	possibly_damaging	0.76	neutral	0.55	neutral	4.67	neutral	0.19	neutral	-0.24	low_impact	1.12	0.74	neutral	0.94	neutral	2.12	16.99	deleterious	0.34	0.5	0.41	neutral	0.2	neutral	0.3	neutral	0.38	neutral	2	0.73	neutral	0.4	neutral	-3	neutral	0.65	deleterious	-1.19	low_impact	0.25	medium_impact	-0.02	medium_impact	0.31	0.8	20.92	18.28	0.34	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11810	11810	C	A	MI.18538	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1051	351	L	M	Cta/Ata	-9.64	0	0.01	probably_damaging	0.98	neutral	0.24	neutral	4.58	neutral	-2.18	neutral	-0.59	low_impact	1.9	0.76	neutral	0.64	neutral	2.70	20.80	deleterious	0.24	0.45	0.6	disease	0.25	neutral	0.34	neutral	0.55	disease	1	0.99	deleterious	0.13	neutral	-2	neutral	0.68	deleterious	-2.31	low_impact	-0.08	medium_impact	0.75	medium_impact	0.46	0.8	20.92	18.28	0.41	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11811	11811	T	G	MI.18539	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1052	351	L	R	cTa/cGa	-6.19	0	0	probably_damaging	1	neutral	0.05	neutral	4.59	neutral	1.6	deleterious	-4.38	medium_impact	2.68	0.69	neutral	0.13	damaging	4.19	23.80	deleterious	0.1	0.4	0.85	disease	0.83	disease	0.72	disease	0.79	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.52	medium_impact	1.53	medium_impact	0.20	0.8	20.92	18.28	0.28	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8559	8559	C	G	MI.1854	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	194	65	P	R	cCc/cGc	0.59	0.05	0	probably_damaging	0.99	neutral	0.35	neutral	1.43	deleterious	-5.34	deleterious	-5.73	medium_impact	2.54	0.99	neutral	0.28	neutral	3.82	23.40	deleterious	0.54328946	0.85	0.72	disease	0.12	neutral	0.61	disease	0.22	neutral	6	0.99	deleterious	0.18	neutral	1	deleterious	0.75	deleterious	-2.65	low_impact	0.14	medium_impact	1.08	medium_impact	0.56	0.85	NA	NA	0.5	N	0.73	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11811	11811	T	C	MI.18540	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1052	351	L	P	cTa/cCa	-6.19	0	0	probably_damaging	1	neutral	0.05	neutral	4.57	neutral	-1.76	deleterious	-4.7	medium_impact	3.03	0.64	neutral	0.12	damaging	3.94	23.50	deleterious	0.04	0.35	0.89	disease	0.83	disease	0.73	disease	0.78	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.52	medium_impact	1.87	medium_impact	0.17	0.8	20.92	18.28	0.23	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11811	11811	T	A	MI.18541	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1052	351	L	Q	cTa/cAa	-6.19	0	0	probably_damaging	1	neutral	0.08	neutral	4.57	neutral	-0.02	deleterious	-4.17	medium_impact	2.48	0.69	neutral	0.17	damaging	4.10	23.70	deleterious	0.12	0.4	0.86	disease	0.57	disease	0.59	disease	0.7	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.39	medium_impact	1.33	medium_impact	0.21	0.8	20.92	18.28	0.31	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11813	11813	C	A	MI.18542	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1054	352	L	I	Ctc/Atc	-10.79	0	0	possibly_damaging	0.64	neutral	0.13	neutral	4.61	neutral	-0.65	neutral	-1.54	medium_impact	2.17	0.81	neutral	0.65	neutral	2.44	19.07	deleterious	0.34	0.5	0.5	disease	0.51	disease	0.52	disease	0.49	neutral	0	0.88	neutral	0.25	neutral	0	NA	0.35	neutral	-0.95	medium_impact	-0.26	medium_impact	1.02	medium_impact	0.51	0.8	20.26	17.44	0.36	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11813	11813	C	G	MI.18543	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1054	352	L	V	Ctc/Gtc	-10.79	0	0	possibly_damaging	0.64	neutral	0.12	neutral	4.6	neutral	-1.21	neutral	-2.49	medium_impact	2.58	0.74	neutral	0.48	neutral	1.76	14.78	neutral	0.31	0.45	0.38	neutral	0.41	neutral	0.62	disease	0.48	neutral	0	0.89	neutral	0.24	neutral	0	NA	0.32	neutral	-0.95	medium_impact	-0.28	medium_impact	1.43	medium_impact	0.41	0.8	20.26	17.44	0.43	N	0.40	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11813	11813	C	T	MI.18544	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1054	352	L	F	Ctc/Ttc	-10.79	0	0	benign	0.08	neutral	0.63	neutral	4.57	neutral	-2.48	neutral	-2.06	low_impact	0.96	0.79	neutral	0.95	neutral	0.62	8.27	deleterious	0.26	0.45	0.51	disease	0.29	neutral	0.4	neutral	0.33	neutral	3	0.28	neutral	0.78	deleterious	-6	neutral	0.17	neutral	0.28	medium_impact	0.33	medium_impact	-0.18	medium_impact	0.54	0.8	20.26	17.44	0.33	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11814	11814	T	C	MI.18545	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1055	352	L	P	cTc/cCc	-0.43	0	0	probably_damaging	0.98	deleterious	0.04	neutral	4.53	deleterious	-3.58	deleterious	-6.12	medium_impact	3.02	0.6	damaging	0.33	neutral	3.98	23.60	deleterious	0.02	0.35	0.9	disease	0.81	disease	0.75	disease	0.8	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.80	deleterious	-2.31	low_impact	-0.57	medium_impact	1.86	medium_impact	0.22	0.8	20.26	17.44	0.31	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	COSM1155513	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11814	11814	T	G	MI.18546	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1055	352	L	R	cTc/cGc	-0.43	0	0	probably_damaging	0.95	neutral	0.06	neutral	4.56	neutral	-1.67	deleterious	-5.17	medium_impact	3.48	0.64	neutral	0.35	neutral	4.16	23.80	deleterious	0.02	0.35	0.87	disease	0.83	disease	0.75	disease	0.8	disease	6	0.99	deleterious	0.06	neutral	1	deleterious	0.79	deleterious	-1.92	low_impact	-0.47	medium_impact	2.32	high_impact	0.29	0.8	20.26	17.44	0.36	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11814	11814	T	A	MI.18547	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1055	352	L	H	cTc/cAc	-0.43	0	0	probably_damaging	0.98	neutral	0.1	neutral	4.52	neutral	-2.35	deleterious	-5.6	medium_impact	3.48	0.7	neutral	0.41	neutral	4.36	24.10	deleterious	0.04	0.35	0.9	disease	0.73	disease	0.71	disease	0.76	disease	5	0.99	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-2.31	low_impact	-0.33	medium_impact	2.32	high_impact	0.29	0.8	20.26	17.44	0.34	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11816	11816	C	G	MI.18548	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1057	353	P	A	Cca/Gca	-13.09	0	0	probably_damaging	1	deleterious	0	neutral	4.29	deleterious	-5.67	deleterious	-7.59	high_impact	3.99	0.61	neutral	0.17	damaging	3.17	22.70	deleterious	0.08	0.35	0.58	disease	0.54	disease	0.7	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	2.82	high_impact	0.59	0.8	47.06	9.5	0.36	N	0.77	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11816	11816	C	T	MI.18549	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1057	353	P	S	Cca/Tca	-13.09	0	0	probably_damaging	1	neutral	0.05	neutral	4.26	deleterious	-5.74	deleterious	-7.59	medium_impact	2.62	0.57	damaging	0.19	damaging	3.98	23.60	deleterious	0.08	0.35	0.66	disease	0.62	disease	0.69	disease	0.59	disease	2	1	deleterious	0.03	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.52	medium_impact	1.47	medium_impact	0.12	0.8	47.06	9.5	0.29	N	0.71	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8559	8559	C	A	MI.1855	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	194	65	P	H	cCc/cAc	0.59	0.05	0	probably_damaging	0.99	neutral	0.54	neutral	1.4	deleterious	-6.47	deleterious	-5.69	low_impact	1.8	0.98	neutral	0.41	neutral	4.23	23.90	deleterious	0.50738370	0.85	0.83	disease	0.15	neutral	0.41	neutral	0.13	neutral	7	0.99	deleterious	0.28	neutral	-2	neutral	0.78	deleterious	-2.65	low_impact	0.33	medium_impact	0.45	medium_impact	0.56	0.85	NA	NA	0.37	N	0.29	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11816	11816	C	A	MI.18550	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1057	353	P	T	Cca/Aca	-13.09	0	0	probably_damaging	1	deleterious	0	neutral	4.25	deleterious	-6.12	deleterious	-7.59	high_impact	3.85	0.64	neutral	0.14	damaging	3.77	23.40	deleterious	0.06	0.35	0.63	disease	0.62	disease	0.7	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	2.68	high_impact	0.50	0.8	47.06	9.5	0.33	N	0.89	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11817	11817	C	A	MI.18551	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1058	353	P	Q	cCa/cAa	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.25	deleterious	-5.9	deleterious	-7.59	high_impact	4.54	0.6	damaging	0.13	damaging	4.16	23.80	deleterious	0.06	0.35	0.8	disease	0.76	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.37	high_impact	0.23	0.8	47.06	9.5	0.6	P	0.84	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11817	11817	C	G	MI.18552	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1058	353	P	R	cCa/cGa	7.17	1	0	probably_damaging	1	deleterious	0.01	neutral	4.29	deleterious	-5.25	deleterious	-8.54	high_impact	3.99	0.59	damaging	0.15	damaging	3.67	23.30	deleterious	0.03	0.35	0.79	disease	0.82	disease	0.79	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-0.92	medium_impact	2.82	high_impact	0.20	0.8	47.06	9.5	0.61	P	0.58	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11817	11817	C	T	MI.18553	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1058	353	P	L	cCa/cTa	7.17	1	0	probably_damaging	1	neutral	0.05	neutral	4.24	deleterious	-6.41	deleterious	-9.48	medium_impact	3.15	0.54	damaging	0.13	damaging	4.46	24.20	deleterious	0.05	0.35	0.53	disease	0.79	disease	0.67	disease	0.68	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.52	medium_impact	1.99	medium_impact	0.64	0.8	47.06	9.5	0.5	N	0.97	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11819	11819	C	G	MI.18554	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1060	354	L	V	Cta/Gta	-14.71	0	0	probably_damaging	1	neutral	0.1	neutral	4.55	neutral	0.07	deleterious	-2.64	medium_impact	2.23	0.78	neutral	0.16	damaging	3.51	23.10	deleterious	0.41	0.5	0.68	disease	0.36	neutral	0.53	disease	0.63	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.71	deleterious	-3.54	low_impact	-0.33	medium_impact	1.08	medium_impact	0.51	0.8	46.84	8.63	0.26	N	0.89	polymorphism	1	0.05	rs28439211	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11819	11819	C	A	MI.18555	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1060	354	L	M	Cta/Ata	-14.71	0	0	probably_damaging	1	neutral	0.12	neutral	4.45	neutral	-2.58	neutral	-1.82	medium_impact	2.23	0.76	neutral	0.25	damaging	3.87	23.50	deleterious	0.29	0.45	0.79	disease	0.31	neutral	0.38	neutral	0.62	disease	2	1	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.28	medium_impact	1.08	medium_impact	0.52	0.8	46.84	8.63	0.37	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11820	11820	T	G	MI.18556	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1061	354	L	R	cTa/cGa	0.95	0.35	0	probably_damaging	1	neutral	0.06	neutral	4.43	neutral	-2.31	deleterious	-5.62	medium_impact	2.68	0.73	neutral	0.13	damaging	4.25	23.90	deleterious	0.03	0.35	0.94	disease	0.8	disease	0.74	disease	0.82	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.86	deleterious	-3.54	low_impact	-0.47	medium_impact	1.53	medium_impact	0.18	0.8	46.84	8.63	0.28	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11820	11820	T	A	MI.18557	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1061	354	L	Q	cTa/cAa	0.95	0.35	0	probably_damaging	1	neutral	0.05	neutral	4.43	deleterious	-3.74	deleterious	-5.58	medium_impact	3.38	0.72	neutral	0.13	damaging	4.27	23.90	deleterious	0.04	0.35	0.9	disease	0.67	disease	0.63	disease	0.73	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.52	medium_impact	2.22	high_impact	0.16	0.8	46.84	8.63	0.34	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11820	11820	T	C	MI.18558	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1061	354	L	P	cTa/cCa	0.95	0.35	0	probably_damaging	1	deleterious	0.04	neutral	4.42	deleterious	-4.24	deleterious	-6.5	medium_impact	3.27	0.63	neutral	0.12	damaging	4.04	23.70	deleterious	0.02	0.35	0.7	disease	0.76	disease	0.74	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-0.57	medium_impact	2.11	high_impact	0.19	0.8	46.84	8.63	0.32	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11822	11822	A	G	MI.18559	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1063	355	M	V	Ata/Gta	-5.5	0	0	possibly_damaging	0.45	deleterious	0.04	neutral	4.64	neutral	1.13	deleterious	-3.23	medium_impact	2.46	0.76	neutral	0.56	neutral	2.82	21.50	deleterious	0.25	0.45	0.37	neutral	0.61	disease	0.64	disease	0.57	disease	1	0.96	neutral	0.3	neutral	4	deleterious	0.58	deleterious	-0.64	medium_impact	-0.57	medium_impact	1.31	medium_impact	0.49	0.8	15.03	15.62	0.39	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8559	8559	C	T	MI.1856	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	194	65	P	L	cCc/cTc	0.59	0.05	0	probably_damaging	0.99	neutral	0.66	neutral	1.44	deleterious	-5.15	deleterious	-4.8	low_impact	1.8	0.99	neutral	0.64	neutral	4.67	24.50	deleterious	0.60355318	0.85	0.73	disease	0.12	neutral	0.36	neutral	0.11	neutral	8	0.99	deleterious	0.34	neutral	-2	neutral	0.75	deleterious	-2.65	low_impact	0.45	medium_impact	0.45	medium_impact	0.78	0.85	NA	NA	0.38	N	0.81	polymorphism	0.95	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11822	11822	A	T	MI.18560	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1063	355	M	L	Ata/Tta	-5.5	0	0	benign	0.02	neutral	0.48	neutral	4.79	neutral	2.33	neutral	-2.33	neutral_impact	0.6	0.67	neutral	0.63	neutral	3.35	22.90	deleterious	0.28	0.45	0.57	disease	0.56	disease	0.48	neutral	0.47	neutral	1	0.5	neutral	0.73	deleterious	-6	neutral	0.54	deleterious	0.87	medium_impact	0.18	medium_impact	-0.53	medium_impact	0.36	0.8	15.03	15.62	0.31	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11822	11822	A	C	MI.18561	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1063	355	M	L	Ata/Cta	-5.5	0	0	benign	0.02	neutral	0.48	neutral	4.79	neutral	2.33	neutral	-2.33	neutral_impact	0.6	0.67	neutral	0.63	neutral	3.25	22.80	deleterious	0.28	0.45	0.57	disease	0.56	disease	0.48	neutral	0.47	neutral	1	0.5	neutral	0.73	deleterious	-6	neutral	0.54	deleterious	0.87	medium_impact	0.18	medium_impact	-0.53	medium_impact	0.36	0.8	15.03	15.62	0.3	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11823	11823	T	C	MI.18562	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1064	355	M	T	aTa/aCa	3.71	0.99	0	benign	0.07	neutral	0.12	neutral	4.67	neutral	3.12	deleterious	-4.66	medium_impact	2.28	0.68	neutral	0.63	neutral	1.84	15.20	deleterious	0.12	0.4	0.61	disease	0.59	disease	0.53	disease	0.47	neutral	1	0.87	neutral	0.53	deleterious	-3	neutral	0.71	deleterious	0.34	medium_impact	-0.28	medium_impact	1.13	medium_impact	0.20	0.8	15.03	15.62	0.51	P	0.47	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11823	11823	T	A	MI.18563	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1064	355	M	K	aTa/aAa	3.71	0.99	0	possibly_damaging	0.66	deleterious	0	neutral	4.58	neutral	-1.88	deleterious	-5.11	high_impact	3.68	0.69	neutral	0.5	neutral	4.32	24.00	deleterious	0.03	0.35	0.81	disease	0.82	disease	0.73	disease	0.76	disease	5	1	deleterious	0.17	neutral	5	deleterious	0.78	deleterious	-0.99	medium_impact	-1.48	low_impact	2.52	high_impact	0.17	0.8	15.03	15.62	0.59	P	0.94	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11824	11824	A	C	MI.18564	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1065	355	M	I	atA/atC	2.79	0.99	0	possibly_damaging	0.45	neutral	0.05	neutral	4.68	neutral	0.69	deleterious	-3.25	medium_impact	2.35	0.74	neutral	0.6	neutral	3.42	23.00	deleterious	0.31	0.45	0.52	disease	0.73	disease	0.57	disease	0.59	disease	2	0.94	neutral	0.3	neutral	0	NA	0.67	deleterious	-0.64	medium_impact	-0.52	medium_impact	1.2	medium_impact	0.41	0.8	15.03	15.62	0.55	P	0.84	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11824	11824	A	T	MI.18565	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1065	355	M	I	atA/atT	2.79	0.99	0	possibly_damaging	0.45	neutral	0.05	neutral	4.68	neutral	0.69	deleterious	-3.25	medium_impact	2.35	0.74	neutral	0.6	neutral	3.58	23.20	deleterious	0.31	0.45	0.52	disease	0.73	disease	0.57	disease	0.59	disease	2	0.94	neutral	0.3	neutral	0	NA	0.67	deleterious	-0.64	medium_impact	-0.52	medium_impact	1.2	medium_impact	0.41	0.8	15.03	15.62	0.55	P	0.84	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11825	11825	G	T	MI.18566	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1066	356	A	S	Gct/Tct	2.1	0.94	0	possibly_damaging	0.64	neutral	0.92	neutral	4.51	neutral	-1.92	neutral	-1.56	low_impact	0.98	0.65	neutral	0.58	neutral	0.91	10.13	neutral	0.21	0.45	0.76	disease	0.28	neutral	0.3	neutral	0.6	disease	2	0.59	neutral	0.64	deleterious	-3	neutral	0.35	neutral	-0.95	medium_impact	0.8	medium_impact	-0.16	medium_impact	0.49	0.8	25.49	20.39	0.35	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11825	11825	G	A	MI.18567	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1066	356	A	T	Gct/Act	2.1	0.94	0	benign	0.05	neutral	0.68	neutral	4.49	neutral	-1.94	neutral	-1.82	neutral_impact	0	0.75	neutral	0.91	neutral	0.83	9.64	deleterious	0.13	0.4	0.86	disease	0.11	neutral	0.25	neutral	0.39	neutral	2	0.25	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.48	medium_impact	0.39	medium_impact	-1.13	low_impact	0.70	0.85	25.49	20.39	0.38	N	0.50	polymorphism	1	0.03	rs879083692	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11825	11825	G	C	MI.18568	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1066	356	A	P	Gct/Cct	2.1	0.94	0	probably_damaging	0.93	neutral	0.05	neutral	4.41	deleterious	-4.55	deleterious	-3.55	medium_impact	2.5	0.65	neutral	0.34	neutral	3.63	23.20	deleterious	0.03	0.35	0.97	disease	0.84	disease	0.69	disease	0.82	disease	6	0.99	deleterious	0.06	neutral	1	deleterious	0.75	deleterious	-1.77	low_impact	-0.52	medium_impact	1.35	medium_impact	0.50	0.8	25.49	20.39	0.42	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11826	11826	C	G	MI.18569	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1067	356	A	G	gCt/gGt	-0.66	0	0	benign	0.08	neutral	0.29	neutral	4.43	neutral	-1.66	deleterious	-2.6	low_impact	1.55	0.71	neutral	0.88	neutral	1.15	11.46	neutral	0.2	0.45	0.36	neutral	0.38	neutral	0.34	neutral	0.45	neutral	1	0.68	neutral	0.61	deleterious	-6	neutral	0.37	neutral	0.28	medium_impact	-0.02	medium_impact	0.41	medium_impact	0.64	0.8	25.49	20.39	0.48	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8561	8561	C	A	MI.1857	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	196	66	P	T	Cca/Aca	7.3	1	0	benign	0.03	neutral	0.53	neutral	1.95	neutral	-1.72	neutral	-1.19	low_impact	1.83	0.98	neutral	0.48	neutral	3.80	23.40	deleterious	0.31771780	0.85	0.34	neutral	0.02	neutral	0.41	neutral	0.05	neutral	9	0.44	neutral	0.75	deleterious	-6	neutral	0.11	neutral	0.68	medium_impact	0.32	medium_impact	0.47	medium_impact	0.46	0.85	NA	NA	0.6	P	0.51	disease_causing	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11826	11826	C	A	MI.18570	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1067	356	A	D	gCt/gAt	-0.66	0	0	possibly_damaging	0.87	deleterious	0.03	neutral	4.41	deleterious	-5.37	deleterious	-4.08	high_impact	3.6	0.73	neutral	0.36	neutral	4.34	24.00	deleterious	0.03	0.35	0.98	disease	0.81	disease	0.68	disease	0.84	disease	7	0.99	deleterious	0.08	neutral	5	deleterious	0.70	deleterious	-1.49	low_impact	-0.64	medium_impact	2.44	high_impact	0.35	0.8	25.49	20.39	0.4	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11826	11826	C	T	MI.18571	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1067	356	A	V	gCt/gTt	-0.66	0	0	possibly_damaging	0.64	neutral	0.11	neutral	4.47	neutral	-2.61	deleterious	-2.68	medium_impact	2.18	0.78	neutral	0.49	neutral	2.71	20.90	deleterious	0.11	0.4	0.83	disease	0.55	disease	0.55	disease	0.67	disease	3	0.9	neutral	0.24	neutral	0	NA	0.46	deleterious	-0.95	medium_impact	-0.31	medium_impact	1.03	medium_impact	0.58	0.8	25.49	20.39	0.38	N	0.45	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11828	11828	T	A	MI.18572	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1069	357	F	I	Ttt/Att	-9.87	0	0	benign	0	neutral	0.24	neutral	4.64	neutral	0.01	neutral	0.84	neutral_impact	0.64	0.74	neutral	0.86	neutral	1.39	12.74	neutral	0.17	0.45	0.64	disease	0.45	neutral	0.37	neutral	0.6	disease	2	0.76	neutral	0.62	deleterious	-6	neutral	0.17	neutral	2.1	high_impact	-0.08	medium_impact	-0.49	medium_impact	0.64	0.8	27.67	28.87	0.45	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11828	11828	T	G	MI.18573	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1069	357	F	V	Ttt/Gtt	-9.87	0	0	benign	0.06	neutral	0.26	neutral	4.66	neutral	0.16	neutral	1.17	neutral_impact	0.74	0.74	neutral	0.88	neutral	0.84	9.69	deleterious	0.15	0.4	0.55	disease	0.42	neutral	0.38	neutral	0.59	disease	2	0.72	neutral	0.6	deleterious	-6	neutral	0.14	neutral	0.41	medium_impact	-0.05	medium_impact	-0.39	medium_impact	0.49	0.8	27.67	28.87	0.44	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11828	11828	T	C	MI.18574	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1069	357	F	L	Ttt/Ctt	-9.87	0	0	benign	0	neutral	1	neutral	4.9	neutral	1.7	neutral	1.1	neutral_impact	-0.5	0.72	neutral	0.98	neutral	0.78	9.36	deleterious	0.22	0.45	0.51	disease	0.28	neutral	0.34	neutral	0.3	neutral	4	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	1.88	high_impact	-1.62	low_impact	0.62	0.8	27.67	28.87	0.26	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11829	11829	T	C	MI.18575	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1070	357	F	S	tTt/tCt	-4.58	0	0	benign	0.01	neutral	0.07	neutral	4.59	neutral	-0.77	neutral	1.29	low_impact	0.92	0.74	neutral	0.97	neutral	1.03	10.84	neutral	0.08	0.35	0.74	disease	0.36	neutral	0.4	neutral	0.64	disease	3	0.93	neutral	0.53	deleterious	-6	neutral	0.21	neutral	1.16	medium_impact	-0.43	medium_impact	-0.22	medium_impact	0.38	0.8	27.67	28.87	0.49	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11829	11829	T	G	MI.18576	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1070	357	F	C	tTt/tGt	-4.58	0	0	possibly_damaging	0.79	neutral	0.05	neutral	4.53	neutral	-2.88	neutral	0.07	medium_impact	2.17	0.76	neutral	0.46	neutral	2.38	18.71	deleterious	0.09	0.35	0.91	disease	0.64	disease	0.56	disease	0.75	disease	5	0.97	neutral	0.13	neutral	0	NA	0.49	deleterious	-1.26	low_impact	-0.52	medium_impact	1.02	medium_impact	0.35	0.8	27.67	28.87	0.4	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11829	11829	T	A	MI.18577	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1070	357	F	Y	tTt/tAt	-4.58	0	0	benign	0.31	deleterious	0.03	neutral	4.58	neutral	-1.13	neutral	-0.39	low_impact	1.47	0.78	neutral	0.62	neutral	2.38	18.67	deleterious	0.22	0.45	0.77	disease	0.39	neutral	0.46	neutral	0.65	disease	3	0.97	neutral	0.36	neutral	-2	neutral	0.21	neutral	-0.39	medium_impact	-0.64	medium_impact	0.33	medium_impact	0.63	0.8	27.67	28.87	0.41	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11830	11830	T	G	MI.18578	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1071	357	F	L	ttT/ttG	0.03	0	0	benign	0	neutral	1	neutral	4.9	neutral	1.7	neutral	1.1	neutral_impact	-0.5	0.72	neutral	0.98	neutral	1.09	11.17	neutral	0.22	0.45	0.51	disease	0.28	neutral	0.34	neutral	0.3	neutral	4	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	1.88	high_impact	-1.62	low_impact	0.62	0.8	27.67	28.87	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11830	11830	T	A	MI.18579	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1071	357	F	L	ttT/ttA	0.03	0	0	benign	0	neutral	1	neutral	4.9	neutral	1.7	neutral	1.1	neutral_impact	-0.5	0.72	neutral	0.98	neutral	1.11	11.29	neutral	0.22	0.45	0.51	disease	0.28	neutral	0.34	neutral	0.3	neutral	4	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	1.88	high_impact	-1.62	low_impact	0.62	0.8	27.67	28.87	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8561	8561	C	T	MI.1858	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	196	66	P	S	Cca/Tca	7.3	1	0	benign	0.06	neutral	0.72	neutral	1.96	neutral	-1.33	neutral	-1.01	low_impact	1.83	0.99	neutral	0.49	neutral	4.18	23.80	deleterious	0.37793802	0.85	0.31	neutral	0.02	neutral	0.41	neutral	0.05	neutral	9	0.2	neutral	0.83	deleterious	-6	neutral	0.12	neutral	0.38	medium_impact	0.52	medium_impact	0.47	medium_impact	0.31	0.85	NA	NA	0.62	P	0.44	disease_causing	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11831	11831	T	C	MI.18580	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1072	358	W	R	Tga/Cga	-8.26	0	0	probably_damaging	1	deleterious	0	neutral	4.62	neutral	-2.07	deleterious	-12.97	high_impact	3.9	0.71	neutral	0.12	damaging	3.70	23.30	deleterious	0.04	0.35	0.77	disease	0.89	disease	0.81	disease	0.79	disease	6	1	deleterious	0	deleterious	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.73	high_impact	0.29	0.8	44.66	7.99	0.46	N	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11831	11831	T	G	MI.18581	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1072	358	W	G	Tga/Gga	-8.26	0	0	probably_damaging	1	deleterious	0.02	neutral	4.61	neutral	-0.19	deleterious	-12.03	medium_impact	3.1	0.69	neutral	0.15	damaging	4.01	23.60	deleterious	0.07	0.35	0.42	neutral	0.79	disease	0.76	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.71	deleterious	-3.54	low_impact	-0.75	medium_impact	1.94	medium_impact	0.23	0.8	44.66	7.99	0.41	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11832	11832	G	T	MI.18582	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1073	358	W	L	tGa/tTa	5.55	1	0	probably_damaging	1	neutral	0.25	neutral	4.87	neutral	2.09	deleterious	-12.03	medium_impact	2.04	0.68	neutral	0.14	damaging	4.34	24.00	deleterious	0.09	0.35	0.41	neutral	0.83	disease	0.75	disease	0.7	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.07	medium_impact	0.89	medium_impact	0.19	0.8	44.66	7.99	0.47	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11832	11832	G	C	MI.18583	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1073	358	W	S	tGa/tCa	5.55	1	0	probably_damaging	1	deleterious	0.02	neutral	4.73	neutral	0.08	deleterious	-12.89	medium_impact	3.15	0.64	neutral	0.22	damaging	4.06	23.70	deleterious	0.07	0.35	0.54	disease	0.84	disease	0.73	disease	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.54	low_impact	-0.75	medium_impact	1.99	medium_impact	0.26	0.8	44.66	7.99	0.53	P	0.93	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11833	11833	A	C	MI.18584	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1074	358	W	C	tgA/tgC	7.17	1	0	probably_damaging	1	deleterious	0.01	neutral	4.69	neutral	-0.45	deleterious	-12.03	medium_impact	3.15	0.71	neutral	0.15	damaging	4.23	23.90	deleterious	0.09	0.35	0.62	disease	0.86	disease	0.76	disease	0.77	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.54	low_impact	-0.92	medium_impact	1.99	medium_impact	0.28	0.8	44.66	7.99	0.54	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11833	11833	A	T	MI.18585	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1074	358	W	C	tgA/tgT	7.17	1	0	probably_damaging	1	deleterious	0.01	neutral	4.69	neutral	-0.45	deleterious	-12.03	medium_impact	3.15	0.71	neutral	0.15	damaging	4.21	23.90	deleterious	0.09	0.35	0.62	disease	0.86	disease	0.76	disease	0.77	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.54	low_impact	-0.92	medium_impact	1.99	medium_impact	0.28	0.8	44.66	7.99	0.54	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11834	11834	T	C	MI.18586	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1075	359	W	R	Tga/Cga	3.25	1	0	probably_damaging	1	deleterious	0	neutral	4.57	neutral	-1.29	deleterious	-13.28	high_impact	3.92	0.54	damaging	0.07	damaging	3.68	23.30	deleterious	0.03	0.35	0.76	disease	0.9	disease	0.82	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.75	high_impact	0.22	0.8	46.41	9.31	0.58	P	0.97	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11834	11834	T	G	MI.18587	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1075	359	W	G	Tga/Gga	3.25	1	0	probably_damaging	1	deleterious	0	neutral	4.57	neutral	-0.41	deleterious	-12.33	high_impact	3.67	0.54	damaging	0.09	damaging	4.00	23.60	deleterious	0.05	0.35	0.63	disease	0.81	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.72	deleterious	-3.54	low_impact	-1.48	low_impact	2.51	high_impact	0.22	0.8	46.41	9.31	0.54	P	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11835	11835	G	C	MI.18588	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1076	359	W	S	tGa/tCa	5.55	1	0	probably_damaging	1	deleterious	0.03	neutral	4.58	neutral	0.6	deleterious	-13.28	medium_impact	3.23	0.5	damaging	0.09	damaging	4.10	23.70	deleterious	0.05	0.35	0.53	disease	0.86	disease	0.76	disease	0.76	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-3.54	low_impact	-0.64	medium_impact	2.07	high_impact	0.24	0.8	46.41	9.31	0.54	P	0.93	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11835	11835	G	T	MI.18589	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1076	359	W	L	tGa/tTa	5.55	1	0	probably_damaging	1	neutral	0.06	neutral	5.02	neutral	2.34	deleterious	-12.32	medium_impact	2.9	0.51	damaging	0.05	damaging	4.35	24.10	deleterious	0.08	0.35	0.41	neutral	0.85	disease	0.75	disease	0.74	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.47	medium_impact	1.74	medium_impact	0.14	0.8	46.41	9.31	0.52	P	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8561	8561	C	G	MI.1859	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	196	66	P	A	Cca/Gca	7.3	1	0	benign	0.01	neutral	0.7	neutral	1.97	neutral	-1.24	neutral	-1.21	low_impact	1.83	0.99	neutral	0.61	neutral	3.37	22.90	deleterious	0.38193460	0.85	0.29	neutral	0.01	neutral	0.4	neutral	0.07	neutral	9	0.27	neutral	0.85	deleterious	-6	neutral	0.11	neutral	1.14	medium_impact	0.5	medium_impact	0.47	medium_impact	0.54	0.85	NA	NA	0.6	P	0.47	disease_causing	0.87	0.03	.	.	.	.	.	.	.	.	.	C8561G	Ataxia w neuropathy, DM, SNHL, and hypogonadism	+	+	Reported	1	.	P	P	damaging
chrM	11836	11836	A	T	MI.18590	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1077	359	W	C	tgA/tgT	9.01	1	0	probably_damaging	1	deleterious	0.01	neutral	4.56	neutral	-1.15	deleterious	-12.33	medium_impact	3.32	0.48	damaging	0.05	damaging	4.23	23.90	deleterious	0.04	0.35	0.8	disease	0.86	disease	0.81	disease	0.79	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	2.16	high_impact	0.20	0.8	46.41	9.31	0.61	P	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11836	11836	A	C	MI.18591	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1077	359	W	C	tgA/tgC	9.01	1	0	probably_damaging	1	deleterious	0.01	neutral	4.56	neutral	-1.15	deleterious	-12.33	medium_impact	3.32	0.48	damaging	0.05	damaging	4.09	23.70	deleterious	0.04	0.35	0.8	disease	0.86	disease	0.81	disease	0.79	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	2.16	high_impact	0.20	0.8	46.41	9.31	0.61	P	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11837	11837	C	A	MI.18592	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1078	360	L	I	Ctt/Att	0.95	0.3	0	possibly_damaging	0.74	neutral	0.06	neutral	4.59	neutral	-1.98	neutral	-1	medium_impact	2.01	0.81	neutral	0.81	neutral	3.05	22.40	deleterious	0.3	0.45	0.73	disease	0.64	disease	0.32	neutral	0.53	disease	1	0.95	neutral	0.16	neutral	0	NA	0.74	deleterious	-1.14	low_impact	-0.47	medium_impact	0.86	medium_impact	0.51	0.8	24.18	21.35	0.37	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11837	11837	C	G	MI.18593	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1078	360	L	V	Ctt/Gtt	0.95	0.3	0	possibly_damaging	0.74	neutral	0.07	neutral	4.53	neutral	-1.66	neutral	-1.8	medium_impact	2.38	0.83	neutral	0.61	neutral	3.53	23.10	deleterious	0.28	0.45	0.68	disease	0.51	disease	0.55	disease	0.63	disease	3	0.95	neutral	0.17	neutral	0	NA	0.71	deleterious	-1.14	low_impact	-0.43	medium_impact	1.23	medium_impact	0.51	0.8	24.18	21.35	0.37	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11837	11837	C	T	MI.18594	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1078	360	L	F	Ctt/Ttt	0.95	0.3	0	benign	0.08	neutral	1	neutral	4.5	neutral	-2.13	neutral	-1.53	neutral_impact	0.76	0.75	neutral	0.78	neutral	1.56	13.66	neutral	0.28	0.45	0.74	disease	0.1	neutral	0.3	neutral	0.43	neutral	2	0.08	neutral	0.96	deleterious	-6	neutral	0.69	deleterious	0.28	medium_impact	1.88	high_impact	-0.37	medium_impact	0.44	0.8	24.18	21.35	0.25	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11838	11838	T	A	MI.18595	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1079	360	L	H	cTt/cAt	-1.12	0	0	probably_damaging	0.98	deleterious	0	neutral	4.38	deleterious	-5.55	deleterious	-4.94	high_impact	4.03	0.72	neutral	0.43	neutral	4.39	24.10	deleterious	0.04	0.35	0.77	disease	0.79	disease	0.65	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-2.31	low_impact	-1.48	low_impact	2.86	high_impact	0.31	0.8	24.18	21.35	0.39	N	0.96	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11838	11838	T	C	MI.18596	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1079	360	L	P	cTt/cCt	-1.12	0	0	probably_damaging	0.98	deleterious	0	neutral	4.38	deleterious	-5.59	deleterious	-5.45	high_impact	4.03	0.61	neutral	0.36	neutral	4.07	23.70	deleterious	0.03	0.35	0.64	disease	0.88	disease	0.67	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.31	low_impact	-1.48	low_impact	2.86	high_impact	0.30	0.8	24.18	21.35	0.35	N	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11838	11838	T	G	MI.18597	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1079	360	L	R	cTt/cGt	-1.12	0	0	probably_damaging	0.97	deleterious	0	neutral	4.39	deleterious	-5.02	deleterious	-4.64	high_impact	4.03	0.66	neutral	0.4	neutral	4.37	24.10	deleterious	0.02	0.35	0.63	disease	0.9	disease	0.68	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.14	low_impact	-1.48	low_impact	2.86	high_impact	0.24	0.8	24.18	21.35	0.37	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11840	11840	C	A	MI.18598	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1081	361	L	M	Cta/Ata	-11.02	0	0	benign	0.03	neutral	0.14	neutral	4.37	neutral	-2.56	neutral	-0.78	low_impact	1.73	0.8	neutral	0.92	neutral	0.54	7.73	deleterious	0.19	0.45	0.66	disease	0.28	neutral	0.31	neutral	0.57	disease	1	0.85	neutral	0.56	deleterious	-6	neutral	0.16	neutral	0.7	medium_impact	-0.24	medium_impact	0.59	medium_impact	0.52	0.8	23.97	24.32	0.44	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11840	11840	C	G	MI.18599	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1081	361	L	V	Cta/Gta	-11.02	0	0	benign	0.01	neutral	0.23	neutral	4.56	neutral	0.07	neutral	-1.58	medium_impact	2.04	0.77	neutral	0.74	neutral	0.48	7.27	deleterious	0.21	0.45	0.54	disease	0.36	neutral	0.3	neutral	0.54	disease	1	0.77	neutral	0.61	deleterious	-3	neutral	0.18	neutral	1.16	medium_impact	-0.09	medium_impact	0.89	medium_impact	0.38	0.8	23.97	24.32	0.42	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8614	8614	T	G	MI.186	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	88	30	L	V	Ttg/Gtg	-20	0	0.01	probably_damaging	0.99	neutral	0.2	neutral	4.37	neutral	-0.15	neutral	-2.39	medium_impact	2.52	0.85	neutral	0.55	neutral	3.24	22.80	deleterious	0.48	0.65	0.55	disease	0.5	neutral	0.33	neutral	0.51	disease	0	0.99	deleterious	0.11	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	-0.05	medium_impact	1.06	medium_impact	0.56	0.9	17.7	14.1	0.35	N	0.69	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8562	8562	C	G	MI.1860	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	197	66	P	R	cCa/cGa	4.52	1	0	benign	0.09	neutral	0.49	neutral	1.95	neutral	-1.56	neutral	-0.81	low_impact	1.14	0.99	neutral	0.37	neutral	0.81	9.51	deleterious	0.37202141	0.85	0.32	neutral	0.03	neutral	0.37	neutral	0.05	neutral	9	0.44	neutral	0.7	deleterious	-6	neutral	0.19	neutral	0.2	medium_impact	0.28	medium_impact	-0.12	medium_impact	0.34	0.85	NA	NA	0.61	P	0.55	disease_causing	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11841	11841	T	A	MI.18600	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1082	361	L	Q	cTa/cAa	-2.27	0	0	possibly_damaging	0.55	deleterious	0	neutral	4.33	deleterious	-4.52	deleterious	-4.56	high_impact	4.12	0.73	neutral	0.44	neutral	2.41	18.87	deleterious	0.03	0.35	0.9	disease	0.72	disease	0.54	disease	0.71	disease	4	1	deleterious	0.23	neutral	5	deleterious	0.48	deleterious	-0.8	medium_impact	-1.48	low_impact	2.95	high_impact	0.30	0.8	23.97	24.32	0.44	N	0.87	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11841	11841	T	C	MI.18601	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1082	361	L	P	cTa/cCa	-2.27	0	0	possibly_damaging	0.55	deleterious	0	neutral	4.33	deleterious	-4.9	deleterious	-5.45	medium_impact	3.42	0.66	neutral	0.37	neutral	2.19	17.45	deleterious	0.03	0.35	0.92	disease	0.84	disease	0.66	disease	0.8	disease	6	1	deleterious	0.23	neutral	4	deleterious	0.53	deleterious	-0.8	medium_impact	-1.48	low_impact	2.26	high_impact	0.26	0.8	23.97	24.32	0.29	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11841	11841	T	G	MI.18602	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1082	361	L	R	cTa/cGa	-2.27	0	0	possibly_damaging	0.55	deleterious	0	neutral	4.34	deleterious	-4.34	deleterious	-4.75	high_impact	4.12	0.71	neutral	0.38	neutral	2.57	19.91	deleterious	0.03	0.35	0.89	disease	0.85	disease	0.66	disease	0.77	disease	5	1	deleterious	0.23	neutral	5	deleterious	0.50	deleterious	-0.8	medium_impact	-1.48	low_impact	2.95	high_impact	0.18	0.8	23.97	24.32	0.4	N	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11843	11843	G	C	MI.18603	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1084	362	A	P	Gca/Cca	-1.12	0	0	probably_damaging	0.99	neutral	0.07	neutral	4.5	deleterious	-4.25	deleterious	-4.08	high_impact	3.52	0.69	neutral	0.37	neutral	3.92	23.50	deleterious	0.03	0.35	0.67	disease	0.85	disease	0.7	disease	0.73	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.80	deleterious	-2.59	low_impact	-0.43	medium_impact	2.36	high_impact	0.48	0.8	24.18	8.7	0.36	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11843	11843	G	T	MI.18604	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1084	362	A	S	Gca/Tca	-1.12	0	0	possibly_damaging	0.86	neutral	0.42	neutral	4.57	neutral	-2.52	neutral	-1.97	medium_impact	2.15	0.71	neutral	0.59	neutral	2.64	20.40	deleterious	0.21	0.45	0.74	disease	0.45	neutral	0.35	neutral	0.63	disease	3	0.85	neutral	0.28	neutral	0	NA	0.73	deleterious	-1.46	low_impact	0.12	medium_impact	1	medium_impact	0.44	0.8	24.18	8.7	0.42	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11843	11843	G	A	MI.18605	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1084	362	A	T	Gca/Aca	-1.12	0	0	probably_damaging	0.95	neutral	0.24	neutral	4.62	neutral	-2.97	deleterious	-2.84	medium_impact	2.12	0.71	neutral	0.59	neutral	3.23	22.80	deleterious	0.11	0.4	0.83	disease	0.46	neutral	0.36	neutral	0.65	disease	3	0.96	neutral	0.15	neutral	1	deleterious	0.75	deleterious	-1.92	low_impact	-0.08	medium_impact	0.97	medium_impact	0.66	0.8	24.18	8.7	0.41	N	0.84	polymorphism	1	0.07	rs28713729	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11844	11844	C	A	MI.18606	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1085	362	A	E	gCa/gAa	2.33	0.87	0	probably_damaging	0.98	neutral	0.09	neutral	4.51	deleterious	-4.8	deleterious	-3.98	high_impact	3.86	0.69	neutral	0.44	neutral	4.62	24.50	deleterious	0.03	0.35	0.91	disease	0.79	disease	0.69	disease	0.78	disease	6	0.99	deleterious	0.06	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	-0.36	medium_impact	2.69	high_impact	0.30	0.8	24.18	8.7	0.5	N	0.89	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11844	11844	C	G	MI.18607	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1085	362	A	G	gCa/gGa	2.33	0.87	0	benign	0.15	neutral	0.16	neutral	4.62	neutral	0.31	deleterious	-3.19	medium_impact	2.48	0.78	neutral	0.71	neutral	3.93	23.50	deleterious	0.22	0.45	0.63	disease	0.57	disease	0.55	disease	0.62	disease	2	0.82	neutral	0.51	deleterious	-3	neutral	0.72	deleterious	-0.01	medium_impact	-0.2	medium_impact	1.33	medium_impact	0.56	0.8	24.18	8.7	0.33	N	0.64	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11844	11844	C	T	MI.18608	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1085	362	A	V	gCa/gTa	2.33	0.87	0	probably_damaging	0.96	neutral	0.42	neutral	4.63	neutral	-1.97	deleterious	-3.08	medium_impact	2.29	0.77	neutral	0.56	neutral	4.51	24.30	deleterious	0.12	0.4	0.81	disease	0.59	disease	0.4	neutral	0.58	disease	2	0.96	neutral	0.23	neutral	1	deleterious	0.76	deleterious	-2.01	low_impact	0.12	medium_impact	1.14	medium_impact	0.54	0.8	24.18	8.7	0.33	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11846	11846	A	G	MI.18609	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1087	363	S	G	Agc/Ggc	-4.58	0	0	benign	0.02	neutral	0.33	neutral	4.55	neutral	-1.9	deleterious	-2.52	medium_impact	2.33	0.78	neutral	0.73	neutral	1.88	15.46	deleterious	0.17	0.45	0.77	disease	0.61	disease	0.5	neutral	0.48	neutral	0	0.65	neutral	0.66	deleterious	-3	neutral	0.31	neutral	0.87	medium_impact	0.03	medium_impact	1.18	medium_impact	0.57	0.8	23.75	22.74	0.31	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8562	8562	C	T	MI.1861	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	197	66	P	L	cCa/cTa	4.52	1	0	benign	0	neutral	0.35	neutral	2.04	neutral	-2.06	neutral	-0.6	neutral_impact	-0.05	1	neutral	0.94	neutral	1.30	12.28	neutral	0.36046463	0.85	0.17	neutral	0.01	neutral	0.3	neutral	0.08	neutral	8	0.65	neutral	0.68	deleterious	-6	neutral	0.08	neutral	2.09	high_impact	0.14	medium_impact	-1.14	low_impact	0.56	0.85	NA	NA	0.62	P	0.22	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11846	11846	A	T	MI.18610	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1087	363	S	C	Agc/Tgc	-4.58	0	0	probably_damaging	0.94	neutral	0.39	neutral	4.59	neutral	-0.83	deleterious	-4.26	low_impact	0.82	0.76	neutral	0.87	neutral	3.47	23.00	deleterious	0.08	0.35	0.82	disease	0.71	disease	0.38	neutral	0.62	disease	2	0.95	neutral	0.23	neutral	-2	neutral	0.71	deleterious	-1.84	low_impact	0.09	medium_impact	-0.32	medium_impact	0.30	0.8	23.75	22.74	0.29	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11846	11846	A	C	MI.18611	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1087	363	S	R	Agc/Cgc	-4.58	0	0	possibly_damaging	0.57	neutral	0.36	neutral	4.53	neutral	-2.56	deleterious	-3.27	high_impact	3.64	0.67	neutral	0.39	neutral	2.28	18.04	deleterious	0.04	0.35	0.74	disease	0.9	disease	0.72	disease	0.77	disease	5	0.65	neutral	0.4	neutral	1	deleterious	0.56	deleterious	-0.83	medium_impact	0.06	medium_impact	2.48	high_impact	0.46	0.8	23.75	22.74	0.37	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11847	11847	G	C	MI.18612	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1088	363	S	T	aGc/aCc	2.1	0.02	0	benign	0.32	neutral	0.4	neutral	4.64	neutral	-0.03	neutral	-2.02	low_impact	1.42	0.76	neutral	0.87	neutral	1.63	14.04	neutral	0.31	0.45	0.46	neutral	0.53	disease	0.39	neutral	0.47	neutral	1	0.52	neutral	0.54	deleterious	-6	neutral	0.32	neutral	-0.41	medium_impact	0.1	medium_impact	0.28	medium_impact	0.56	0.8	23.75	22.74	0.36	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11847	11847	G	T	MI.18613	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1088	363	S	I	aGc/aTc	2.1	0.02	0	possibly_damaging	0.89	neutral	0.47	neutral	4.72	neutral	0.65	deleterious	-4.88	low_impact	1.9	0.69	neutral	0.54	neutral	3.96	23.60	deleterious	0.06	0.35	0.42	neutral	0.89	disease	0.53	disease	0.65	disease	3	0.88	neutral	0.29	neutral	-3	neutral	0.64	deleterious	-1.57	low_impact	0.17	medium_impact	0.75	medium_impact	0.39	0.8	23.75	22.74	0.31	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11847	11847	G	A	MI.18614	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1088	363	S	N	aGc/aAc	2.1	0.02	0	benign	0.01	neutral	0.48	neutral	4.56	neutral	-1.52	neutral	-0.08	neutral_impact	0.53	0.72	neutral	0.65	neutral	-0.49	0.24	neutral	0.41	0.5	0.41	neutral	0.25	neutral	0.37	neutral	0.44	neutral	1	0.51	neutral	0.74	deleterious	-6	neutral	0.15	neutral	1.16	medium_impact	0.18	medium_impact	-0.6	medium_impact	0.34	0.8	23.75	22.74	0.43	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11849	11849	C	T	MI.18615	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1090	364	L	F	Ctc/Ttc	0.26	0	0	benign	0.29	deleterious	0.04	neutral	4.3	neutral	-2.19	deleterious	-3.4	medium_impact	2.42	0.72	neutral	0.56	neutral	4.08	23.70	deleterious	0.2	0.45	0.37	neutral	0.64	disease	0.59	disease	0.57	disease	1	0.95	neutral	0.38	neutral	1	deleterious	0.71	deleterious	-0.35	medium_impact	-0.57	medium_impact	1.27	medium_impact	0.57	0.8	48.15	9.19	0.41	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11849	11849	C	A	MI.18616	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1090	364	L	I	Ctc/Atc	0.26	0	0	possibly_damaging	0.86	neutral	0.19	neutral	4.21	neutral	-2.52	neutral	-1.82	medium_impact	2.2	0.71	neutral	0.54	neutral	4.15	23.80	deleterious	0.28	0.45	0.6	disease	0.58	disease	0.57	disease	0.51	disease	0	0.92	neutral	0.17	neutral	0	NA	0.74	deleterious	-1.46	low_impact	-0.15	medium_impact	1.05	medium_impact	0.67	0.85	48.15	9.19	0.4	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11849	11849	C	G	MI.18617	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1090	364	L	V	Ctc/Gtc	0.26	0	0	possibly_damaging	0.86	neutral	0.25	neutral	4.23	neutral	-2.53	deleterious	-2.77	medium_impact	2.08	0.65	neutral	0.53	neutral	3.52	23.10	deleterious	0.26	0.45	0.5	neutral	0.42	neutral	0.58	disease	0.43	neutral	1	0.89	neutral	0.2	neutral	0	NA	0.70	deleterious	-1.46	low_impact	-0.07	medium_impact	0.93	medium_impact	0.49	0.8	48.15	9.19	0.37	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11850	11850	T	C	MI.18618	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1091	364	L	P	cTc/cCc	-0.43	0	0	probably_damaging	0.99	deleterious	0	neutral	4.14	deleterious	-6.33	deleterious	-6.52	high_impact	3.77	0.58	damaging	0.4	neutral	4.02	23.60	deleterious	0.02	0.35	0.89	disease	0.82	disease	0.77	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.59	low_impact	-1.48	low_impact	2.6	high_impact	0.28	0.8	48.15	9.19	0.39	N	0.98	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11850	11850	T	A	MI.18619	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1091	364	L	H	cTc/cAc	-0.43	0	0	probably_damaging	0.99	deleterious	0	neutral	4.14	deleterious	-6.29	deleterious	-6.41	high_impact	4.12	0.65	neutral	0.36	neutral	4.27	23.90	deleterious	0.04	0.35	0.94	disease	0.76	disease	0.73	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.59	low_impact	-1.48	low_impact	2.95	high_impact	0.33	0.8	48.15	9.19	0.34	N	0.96	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8562	8562	C	A	MI.1862	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	197	66	P	Q	cCa/cAa	4.52	1	0	benign	0.19	neutral	0.71	neutral	2.01	neutral	-0.67	neutral	1.12	neutral_impact	-0.76	0.99	neutral	0.96	neutral	1.54	13.53	neutral	0.34743468	0.85	0.19	neutral	0.02	neutral	0.28	neutral	0.07	neutral	9	0.18	neutral	0.76	deleterious	-6	neutral	0.24	neutral	-0.16	medium_impact	0.51	medium_impact	-1.75	low_impact	0.33	0.85	NA	NA	0.5	N	0.12	disease_causing	0.93	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11850	11850	T	G	MI.18620	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1091	364	L	R	cTc/cGc	-0.43	0	0	probably_damaging	0.98	deleterious	0	neutral	4.15	deleterious	-5.76	deleterious	-5.57	high_impact	4.12	0.58	damaging	0.35	neutral	4.31	24.00	deleterious	0.02	0.35	0.92	disease	0.86	disease	0.76	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.31	low_impact	-1.48	low_impact	2.95	high_impact	0.19	0.8	48.15	9.19	0.4	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11852	11852	G	T	MI.18621	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1093	365	A	S	Gct/Tct	-4.81	0	0	benign	0.4	neutral	0.91	neutral	4.88	neutral	-0.91	neutral	-0.69	low_impact	1.07	0.68	neutral	0.79	neutral	0.88	9.96	deleterious	0.27	0.45	0.66	disease	0.47	neutral	0.32	neutral	0.6	disease	2	0.32	neutral	0.76	deleterious	-6	neutral	0.30	neutral	-0.55	medium_impact	0.77	medium_impact	-0.07	medium_impact	0.45	0.8	23.31	15.3	0.26	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11852	11852	G	A	MI.18622	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1093	365	A	T	Gct/Act	-4.81	0	0	benign	0.02	neutral	0.57	neutral	4.51	deleterious	-3.37	neutral	-0.26	neutral_impact	0.08	0.79	neutral	0.92	neutral	0.51	7.53	deleterious	0.13	0.4	0.4	neutral	0.26	neutral	0.32	neutral	0.45	neutral	1	0.4	neutral	0.78	deleterious	-6	neutral	0.13	neutral	0.87	medium_impact	0.27	medium_impact	-1.05	low_impact	0.75	0.85	23.31	15.3	0.28	N	0.01	polymorphism	1	0.02	rs373915038	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11852	11852	G	C	MI.18623	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1093	365	A	P	Gct/Cct	-4.81	0	0	possibly_damaging	0.79	deleterious	0.03	neutral	4.45	deleterious	-5.61	deleterious	-2.85	medium_impact	3.4	0.66	neutral	0.36	neutral	3.63	23.20	deleterious	0.04	0.35	0.71	disease	0.92	disease	0.73	disease	0.79	disease	6	0.98	neutral	0.12	neutral	4	deleterious	0.66	deleterious	-1.26	low_impact	-0.64	medium_impact	2.24	high_impact	0.52	0.8	23.31	15.3	0.35	N	0.78	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11853	11853	C	A	MI.18624	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1094	365	A	D	gCt/gAt	0.26	0	0	possibly_damaging	0.73	deleterious	0.03	neutral	4.46	deleterious	-4.93	deleterious	-3.14	medium_impact	3.4	0.7	neutral	0.4	neutral	4.21	23.90	deleterious	0.03	0.35	0.84	disease	0.88	disease	0.71	disease	0.78	disease	6	0.98	neutral	0.15	neutral	4	deleterious	0.67	deleterious	-1.12	low_impact	-0.64	medium_impact	2.24	high_impact	0.31	0.8	23.31	15.3	0.34	N	0.83	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11853	11853	C	G	MI.18625	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1094	365	A	G	gCt/gGt	0.26	0	0	benign	0.4	neutral	0.14	neutral	4.49	neutral	-2.92	deleterious	-2.57	low_impact	1.61	0.72	neutral	0.59	neutral	2.30	18.17	deleterious	0.21	0.45	0.51	disease	0.64	disease	0.5	neutral	0.51	disease	0	0.84	neutral	0.37	neutral	-6	neutral	0.32	neutral	-0.55	medium_impact	-0.24	medium_impact	0.47	medium_impact	0.65	0.8	23.31	15.3	0.34	N	0.55	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11853	11853	C	T	MI.18626	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1094	365	A	V	gCt/gTt	0.26	0	0	benign	0.4	neutral	0.19	neutral	4.5	deleterious	-3.96	neutral	-2.01	low_impact	1.8	0.74	neutral	0.57	neutral	2.71	20.90	deleterious	0.07	0.35	0.52	disease	0.69	disease	0.52	disease	0.58	disease	2	0.78	neutral	0.4	neutral	-6	neutral	0.36	neutral	-0.55	medium_impact	-0.15	medium_impact	0.66	medium_impact	0.73	0.85	23.31	15.3	0.36	N	0.52	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11855	11855	A	G	MI.18627	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1096	366	N	D	Aac/Gac	-11.02	0	0	probably_damaging	1	deleterious	0	neutral	4.5	deleterious	-3.37	deleterious	-4.74	high_impact	4.58	0.61	neutral	0.14	damaging	3.93	23.50	deleterious	0.31	0.5	0.89	disease	0.71	disease	0.76	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-1.48	low_impact	3.41	high_impact	0.26	0.8	46.62	9.19	0.49	N	0.96	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11855	11855	A	T	MI.18628	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1096	366	N	Y	Aac/Tac	-11.02	0	0	probably_damaging	1	deleterious	0	neutral	4.56	neutral	-1.4	deleterious	-7.59	high_impact	4.24	0.58	damaging	0.11	damaging	3.83	23.40	deleterious	0.07	0.35	0.7	disease	0.83	disease	0.74	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3.07	high_impact	0.20	0.8	46.62	9.19	0.38	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11855	11855	A	C	MI.18629	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1096	366	N	H	Aac/Cac	-11.02	0	0	probably_damaging	1	deleterious	0.01	neutral	4.5	neutral	-2.81	deleterious	-4.74	high_impact	4.58	0.58	damaging	0.12	damaging	3.13	22.60	deleterious	0.24	0.45	0.85	disease	0.78	disease	0.78	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	3.41	high_impact	0.24	0.8	46.62	9.19	0.5	N	0.97	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8564	8564	C	A	MI.1863	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	199	67	Q	K	Caa/Aaa	0.13	0	0	benign	0	neutral	0.3	neutral	1.79	neutral	-0.73	neutral	-2.31	medium_impact	2.96	0.98	neutral	0.3	neutral	4.16	23.80	deleterious	0.71418440	0.85	0.25	neutral	0.06	neutral	0.55	disease	0.15	neutral	7	0.7	neutral	0.65	deleterious	-3	neutral	0.17	neutral	2.09	high_impact	0.08	medium_impact	1.44	medium_impact	0.71	0.85	NA	NA	0.5	N	0.62	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11856	11856	A	T	MI.18630	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1097	366	N	I	aAc/aTc	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.6	neutral	1.85	deleterious	-8.54	high_impact	4.58	0.58	damaging	0.15	damaging	4.00	23.60	deleterious	0.12	0.4	0.41	neutral	0.89	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.54	low_impact	-1.48	low_impact	3.41	high_impact	0.20	0.8	46.62	9.19	0.61	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11856	11856	A	C	MI.18631	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1097	366	N	T	aAc/aCc	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.54	neutral	0	deleterious	-5.69	high_impact	3.68	0.64	neutral	0.14	damaging	3.45	23.00	deleterious	0.21	0.45	0.6	disease	0.74	disease	0.65	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.54	low_impact	-1.48	low_impact	2.52	high_impact	0.29	0.8	46.62	9.19	0.59	P	0.95	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11856	11856	A	G	MI.18632	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1097	366	N	S	aAc/aGc	8.55	1	0	probably_damaging	1	deleterious	0.03	neutral	4.58	neutral	1.02	deleterious	-4.74	medium_impact	2.48	0.58	damaging	0.17	damaging	3.21	22.70	deleterious	0.46	0.55	0.63	disease	0.72	disease	0.67	disease	0.67	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-3.54	low_impact	-0.64	medium_impact	1.33	medium_impact	0.19	0.8	46.62	9.19	0.59	P	0.85	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11857	11857	C	G	MI.18633	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1098	366	N	K	aaC/aaG	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.51	neutral	-2.15	deleterious	-5.69	high_impact	4.58	0.56	damaging	0.12	damaging	4.09	23.70	deleterious	0.21	0.45	0.8	disease	0.81	disease	0.77	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.41	high_impact	0.32	0.8	46.62	9.19	0.66	P	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11857	11857	C	A	MI.18634	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1098	366	N	K	aaC/aaA	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.51	neutral	-2.15	deleterious	-5.69	high_impact	4.58	0.56	damaging	0.12	damaging	4.56	24.40	deleterious	0.21	0.45	0.8	disease	0.81	disease	0.77	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.41	high_impact	0.32	0.8	46.62	9.19	0.66	P	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11858	11858	C	T	MI.18635	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1099	367	L	F	Ctc/Ttc	-1.12	0	0	probably_damaging	0.97	deleterious	0.04	neutral	4.5	neutral	-2.78	deleterious	-3.53	medium_impact	2.12	0.69	neutral	0.45	neutral	4.04	23.70	deleterious	0.26	0.45	0.76	disease	0.68	disease	0.61	disease	0.69	disease	4	0.99	deleterious	0.04	neutral	5	deleterious	0.76	deleterious	-2.14	low_impact	-0.57	medium_impact	0.97	medium_impact	0.52	0.8	45.32	9.01	0.32	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11858	11858	C	G	MI.18636	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1099	367	L	V	Ctc/Gtc	-1.12	0	0	possibly_damaging	0.86	deleterious	0.03	neutral	4.59	neutral	-0.37	deleterious	-2.58	medium_impact	2.35	0.81	neutral	0.5	neutral	3.51	23.10	deleterious	0.35	0.5	0.59	disease	0.49	neutral	0.5	neutral	0.57	disease	1	0.98	deleterious	0.09	neutral	4	deleterious	0.71	deleterious	-1.46	low_impact	-0.64	medium_impact	1.2	medium_impact	0.42	0.8	45.32	9.01	0.38	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11858	11858	C	A	MI.18637	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1099	367	L	I	Ctc/Atc	-1.12	0	0	possibly_damaging	0.86	neutral	0.1	neutral	4.61	neutral	-0.34	neutral	-1.76	low_impact	1.55	0.73	neutral	0.66	neutral	4.32	24.00	deleterious	0.32	0.5	0.64	disease	0.53	disease	0.3	neutral	0.48	neutral	0	0.95	neutral	0.12	neutral	-3	neutral	0.73	deleterious	-1.46	low_impact	-0.33	medium_impact	0.41	medium_impact	0.55	0.8	45.32	9.01	0.42	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11859	11859	T	A	MI.18638	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1100	367	L	H	cTc/cAc	-0.2	0	0	probably_damaging	0.99	deleterious	0	neutral	4.48	deleterious	-4.56	deleterious	-6.24	high_impact	3.67	0.71	neutral	0.34	neutral	4.26	23.90	deleterious	0.06	0.35	0.73	disease	0.78	disease	0.68	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.59	low_impact	-1.48	low_impact	2.51	high_impact	0.20	0.8	45.32	9.01	0.32	N	0.96	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11859	11859	T	C	MI.18639	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1100	367	L	P	cTc/cCc	-0.2	0	0	probably_damaging	0.99	deleterious	0	neutral	4.48	deleterious	-4.61	deleterious	-6.24	medium_impact	3.33	0.61	neutral	0.33	neutral	4.01	23.60	deleterious	0.03	0.35	0.82	disease	0.89	disease	0.6	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-2.59	low_impact	-1.48	low_impact	2.17	high_impact	0.24	0.8	45.32	9.01	0.29	N	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8564	8564	C	G	MI.1864	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	199	67	Q	E	Caa/Gaa	0.13	0	0	benign	0.01	neutral	0.28	neutral	1.72	neutral	-1.53	neutral	-1.75	medium_impact	2.96	0.97	neutral	0.38	neutral	4.08	23.70	deleterious	0.74880421	0.85	0.4	neutral	0.04	neutral	0.55	disease	0.14	neutral	7	0.71	neutral	0.64	deleterious	-3	neutral	0.17	neutral	1.14	medium_impact	0.06	medium_impact	1.44	medium_impact	0.74	0.85	NA	NA	0.49	N	0.59	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11859	11859	T	G	MI.18640	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1100	367	L	R	cTc/cGc	-0.2	0	0	probably_damaging	0.98	deleterious	0	neutral	4.49	deleterious	-4.03	deleterious	-5.29	high_impact	3.67	0.66	neutral	0.32	neutral	4.31	24.00	deleterious	0.04	0.35	0.69	disease	0.88	disease	0.72	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.31	low_impact	-1.48	low_impact	2.51	high_impact	0.15	0.8	45.32	9.01	0.33	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11861	11861	G	C	MI.18641	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1102	368	A	P	Gcc/Ccc	-2.73	0	0	probably_damaging	1	neutral	0.05	neutral	4.43	deleterious	-4.7	deleterious	-4.63	medium_impact	3.23	0.66	neutral	0.11	damaging	3.89	23.50	deleterious	0.04	0.35	0.37	neutral	0.87	disease	0.64	disease	0.71	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.52	medium_impact	2.07	high_impact	0.28	0.8	46.41	8.92	0.29	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11861	11861	G	A	MI.18642	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1102	368	A	T	Gcc/Acc	-2.73	0	0	probably_damaging	1	deleterious	0	neutral	4.5	neutral	-2.92	deleterious	-3.72	high_impact	4.03	0.65	neutral	0.11	damaging	4.33	24.00	deleterious	0.06	0.35	0.38	neutral	0.78	disease	0.63	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.54	low_impact	-1.48	low_impact	2.86	high_impact	0.61	0.8	46.41	8.92	0.37	N	0.82	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11861	11861	G	T	MI.18643	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1102	368	A	S	Gcc/Tcc	-2.73	0	0	probably_damaging	1	neutral	0.24	neutral	4.51	neutral	-1.6	deleterious	-2.74	medium_impact	2.09	0.61	neutral	0.2	damaging	3.79	23.40	deleterious	0.11	0.4	0.52	disease	0.77	disease	0.52	disease	0.58	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.08	medium_impact	0.94	medium_impact	0.34	0.8	46.41	8.92	0.31	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11862	11862	C	A	MI.18644	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1103	368	A	D	gCc/gAc	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.42	deleterious	-5.17	deleterious	-5.51	high_impact	4.38	0.7	neutral	0.09	damaging	4.66	24.50	deleterious	0.03	0.35	0.89	disease	0.9	disease	0.74	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.21	high_impact	0.18	0.8	46.41	8.92	0.6	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11862	11862	C	G	MI.18645	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1103	368	A	G	gCc/gGc	6.01	1	0	probably_damaging	1	neutral	0.39	neutral	5.47	neutral	3.61	deleterious	-3.45	low_impact	1.82	0.64	neutral	0.17	damaging	4.06	23.70	deleterious	0.14	0.4	0.62	disease	0.62	disease	0.46	neutral	0.46	neutral	1	1	deleterious	0.2	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	0.09	medium_impact	0.68	medium_impact	0.52	0.8	46.41	8.92	0.56	P	0.79	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11862	11862	C	T	MI.18646	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1103	368	A	V	gCc/gTc	6.01	1	0	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-3.42	deleterious	-3.75	high_impact	4.38	0.62	neutral	0.12	damaging	4.62	24.50	deleterious	0.05	0.35	0.41	neutral	0.77	disease	0.64	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.54	low_impact	-1.48	low_impact	3.21	high_impact	0.56	0.8	46.41	8.92	0.57	P	0.72	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11864	11864	T	G	MI.18647	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1105	369	L	V	Tta/Gta	-6.19	0	0	probably_damaging	1	neutral	0.34	neutral	4.41	neutral	-1.44	deleterious	-2.75	medium_impact	2.23	0.7	neutral	0.53	neutral	3.50	23.10	deleterious	0.38	0.5	0.77	disease	0.46	neutral	0.49	neutral	0.63	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	0.04	medium_impact	1.08	medium_impact	0.49	0.8	43.14	7.89	0.33	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11864	11864	T	A	MI.18648	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1105	369	L	M	Tta/Ata	-6.19	0	0	probably_damaging	1	neutral	0.09	neutral	4.35	neutral	-2.76	neutral	-1.82	low_impact	1.92	0.78	neutral	0.65	neutral	3.66	23.20	deleterious	0.36	0.5	0.78	disease	0.47	neutral	0.45	neutral	0.61	disease	2	1	deleterious	0.05	neutral	-2	neutral	0.74	deleterious	-3.54	low_impact	-0.36	medium_impact	0.77	medium_impact	0.46	0.8	43.14	7.89	0.36	N	0.90	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11865	11865	T	G	MI.18649	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1106	369	L	W	tTa/tGa	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	4.31	deleterious	-6.56	deleterious	-5.58	high_impact	3.68	0.68	neutral	0.39	neutral	3.88	23.50	deleterious	0.05	0.35	0.68	disease	0.69	disease	0.62	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	2.52	high_impact	0.28	0.8	43.14	7.89	0.35	N	0.98	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8565	8565	A	G	MI.1865	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	200	67	Q	R	cAa/cGa	0.59	0	0	benign	0	neutral	0.38	neutral	1.78	neutral	-0.7	neutral	-2.22	low_impact	1.81	1	neutral	0.58	neutral	0.53	7.66	deleterious	0.83186441	0.90	0.19	neutral	0.05	neutral	0.48	neutral	0.05	neutral	9	0.62	neutral	0.69	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.17	medium_impact	0.45	medium_impact	0.55	0.85	NA	NA	0.52	N	0.55	polymorphism	1	0.08	rs878853052	Uncertain_significance	not_provided	237174	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11865	11865	T	C	MI.18650	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1106	369	L	S	tTa/tCa	-0.2	0	0	probably_damaging	1	neutral	0.07	neutral	4.34	deleterious	-3.99	deleterious	-5.53	medium_impact	2.37	0.73	neutral	0.47	neutral	3.84	23.40	deleterious	0.03	0.35	0.94	disease	0.66	disease	0.62	disease	0.8	disease	6	1	deleterious	0.04	neutral	1	deleterious	0.80	deleterious	-3.54	low_impact	-0.43	medium_impact	1.22	medium_impact	0.35	0.8	43.14	7.89	0.31	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11866	11866	A	T	MI.18651	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1107	369	L	F	ttA/ttT	5.55	0.87	0	probably_damaging	1	neutral	0.22	neutral	4.36	neutral	-2.73	deleterious	-3.72	medium_impact	2.23	0.72	neutral	0.54	neutral	3.66	23.20	deleterious	0.29	0.45	0.79	disease	0.61	disease	0.5	neutral	0.53	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.11	medium_impact	1.08	medium_impact	0.37	0.8	43.14	7.89	0.5	P	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11866	11866	A	C	MI.18652	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1107	369	L	F	ttA/ttC	5.55	0.87	0	probably_damaging	1	neutral	0.22	neutral	4.36	neutral	-2.73	deleterious	-3.72	medium_impact	2.23	0.72	neutral	0.54	neutral	3.54	23.10	deleterious	0.29	0.45	0.79	disease	0.61	disease	0.5	neutral	0.53	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.11	medium_impact	1.08	medium_impact	0.37	0.8	43.14	7.89	0.5	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11867	11867	C	G	MI.18653	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1108	370	P	A	Ccc/Gcc	-9.64	0	0	probably_damaging	1	deleterious	0	neutral	3.56	deleterious	-5.9	deleterious	-7.47	high_impact	4.62	0.51	damaging	0.11	damaging	3.19	22.70	deleterious	0.05	0.35	0.43	neutral	0.62	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.42	0.8	47.06	9.43	0.45	N	0.77	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11867	11867	C	A	MI.18654	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1108	370	P	T	Ccc/Acc	-9.64	0	0	probably_damaging	1	deleterious	0	neutral	3.54	deleterious	-6.35	deleterious	-7.47	high_impact	3.92	0.56	damaging	0.08	damaging	3.75	23.30	deleterious	0.05	0.35	0.36	neutral	0.77	disease	0.73	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	2.75	high_impact	0.35	0.8	47.06	9.43	0.34	N	0.89	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11867	11867	C	T	MI.18655	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1108	370	P	S	Ccc/Tcc	-9.64	0	0	probably_damaging	1	deleterious	0	neutral	3.54	deleterious	-6.59	deleterious	-7.47	high_impact	4.62	0.53	damaging	0.09	damaging	3.99	23.60	deleterious	0.04	0.35	0.52	disease	0.8	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.19	0.8	47.06	9.43	0.43	N	0.71	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11868	11868	C	A	MI.18656	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1109	370	P	H	cCc/cAc	4.4	0.99	0	probably_damaging	1	deleterious	0	neutral	3.52	deleterious	-8.05	deleterious	-8.4	high_impact	4.62	0.56	damaging	0.06	damaging	4.22	23.90	deleterious	0.04	0.35	0.82	disease	0.85	disease	0.83	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.27	0.8	47.06	9.43	0.59	P	0.70	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11868	11868	C	T	MI.18657	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1109	370	P	L	cCc/cTc	4.4	0.99	0	probably_damaging	1	deleterious	0	neutral	3.62	deleterious	-5.06	deleterious	-9.34	high_impact	4.07	0.52	damaging	0.06	damaging	4.44	24.20	deleterious	0.04	0.35	0.78	disease	0.87	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	2.9	high_impact	0.57	0.8	47.06	9.43	0.56	P	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11868	11868	C	G	MI.18658	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1109	370	P	R	cCc/cGc	4.4	0.99	0	probably_damaging	1	deleterious	0	neutral	3.53	deleterious	-7.34	deleterious	-8.4	high_impact	4.62	0.61	neutral	0.08	damaging	3.69	23.30	deleterious	0.03	0.35	0.77	disease	0.87	disease	0.84	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.45	high_impact	0.26	0.8	47.06	9.43	0.62	P	0.58	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11870	11870	C	T	MI.18659	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1111	371	P	S	Ccc/Tcc	-8.26	0	0	probably_damaging	1	deleterious	0	neutral	4.34	deleterious	-4.42	deleterious	-7.47	high_impact	3.81	0.61	neutral	0.51	neutral	4.01	23.60	deleterious	0.13	0.4	0.89	disease	0.79	disease	0.73	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	2.64	high_impact	0.12	0.8	45.97	9.16	0.34	N	0.71	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8565	8565	A	T	MI.1866	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	200	67	Q	L	cAa/cTa	0.59	0	0	benign	0.01	neutral	0.65	neutral	1.66	neutral	-2.51	deleterious	-3.84	medium_impact	1.99	0.98	neutral	0.38	neutral	1.93	15.74	deleterious	0.67403744	0.85	0.56	disease	0.07	neutral	0.48	neutral	0.05	neutral	9	0.33	neutral	0.82	deleterious	-3	neutral	0.19	neutral	1.14	medium_impact	0.44	medium_impact	0.61	medium_impact	0.46	0.85	NA	NA	0.37	N	0.77	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11870	11870	C	G	MI.18660	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1111	371	P	A	Ccc/Gcc	-8.26	0	0	probably_damaging	1	deleterious	0	neutral	4.36	deleterious	-3.57	deleterious	-7.47	high_impact	3.96	0.52	damaging	0.48	neutral	3.21	22.70	deleterious	0.14	0.4	0.84	disease	0.6	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.79	high_impact	0.54	0.8	45.97	9.16	0.37	N	0.77	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11870	11870	C	A	MI.18661	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1111	371	P	T	Ccc/Acc	-8.26	0	0	probably_damaging	1	deleterious	0.01	neutral	4.35	deleterious	-4.15	deleterious	-7.47	high_impact	3.7	0.61	neutral	0.41	neutral	3.80	23.40	deleterious	0.12	0.4	0.68	disease	0.76	disease	0.73	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-0.92	medium_impact	2.53	high_impact	0.43	0.8	45.97	9.16	0.32	N	0.89	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11871	11871	C	A	MI.18662	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1112	371	P	H	cCc/cAc	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.31	deleterious	-5.8	deleterious	-8.4	high_impact	4.5	0.54	damaging	0.35	neutral	4.13	23.80	deleterious	0.07	0.35	0.95	disease	0.84	disease	0.8	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.24	0.8	45.97	9.16	0.61	P	0.70	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11871	11871	C	T	MI.18663	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1112	371	P	L	cCc/cTc	7.17	1	0	probably_damaging	1	neutral	0.09	neutral	4.46	neutral	-1.93	deleterious	-9.33	medium_impact	2.79	0.54	damaging	0.44	neutral	4.51	24.30	deleterious	0.11	0.4	0.88	disease	0.85	disease	0.69	disease	0.77	disease	5	1	deleterious	0.05	neutral	1	deleterious	0.85	deleterious	-3.54	low_impact	-0.36	medium_impact	1.63	medium_impact	0.72	0.85	45.97	9.16	0.63	P	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11871	11871	C	G	MI.18664	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1112	371	P	R	cCc/cGc	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.32	deleterious	-5.35	deleterious	-8.4	high_impact	4.5	0.58	damaging	0.41	neutral	3.70	23.30	deleterious	0.05	0.35	0.88	disease	0.85	disease	0.82	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.33	high_impact	0.27	0.8	45.97	9.16	0.64	P	0.58	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11873	11873	A	C	MI.18665	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1114	372	T	P	Act/Cct	-8.26	0	0	probably_damaging	0.96	deleterious	0.02	neutral	4.42	deleterious	-4.87	deleterious	-3.8	high_impact	3.92	0.72	neutral	0.33	neutral	3.58	23.20	deleterious	0.04	0.35	0.8	disease	0.82	disease	0.58	disease	0.75	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.80	deleterious	-2.01	low_impact	-0.75	medium_impact	2.75	high_impact	0.30	0.8	14.38	17.44	0.37	N	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11873	11873	A	G	MI.18666	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1114	372	T	A	Act/Gct	-8.26	0	0	possibly_damaging	0.64	neutral	0.08	neutral	4.47	neutral	-2.26	neutral	-2.38	medium_impact	2.94	0.77	neutral	0.65	neutral	2.50	19.44	deleterious	0.21	0.45	0.41	neutral	0.4	neutral	0.52	disease	0.49	neutral	0	0.92	neutral	0.22	neutral	0	NA	0.68	deleterious	-0.95	medium_impact	-0.39	medium_impact	1.78	medium_impact	0.33	0.8	14.38	17.44	0.45	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11873	11873	A	T	MI.18667	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1114	372	T	S	Act/Tct	-8.26	0	0	benign	0.13	neutral	1	neutral	4.5	neutral	-2.42	neutral	-1.2	neutral_impact	0.15	0.77	neutral	0.99	neutral	1.84	15.22	deleterious	0.34	0.5	0.48	neutral	0.12	neutral	0.22	neutral	0.3	neutral	4	0.13	neutral	0.94	deleterious	-6	neutral	0.67	deleterious	0.06	medium_impact	1.88	high_impact	-0.98	medium_impact	0.52	0.8	14.38	17.44	0.27	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11874	11874	C	G	MI.18668	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1115	372	T	S	aCt/aGt	-0.66	0	0	benign	0.13	neutral	1	neutral	4.5	neutral	-2.42	neutral	-1.2	neutral_impact	0.15	0.77	neutral	0.99	neutral	1.95	15.91	deleterious	0.34	0.5	0.48	neutral	0.12	neutral	0.22	neutral	0.3	neutral	4	0.13	neutral	0.94	deleterious	-6	neutral	0.67	deleterious	0.06	medium_impact	1.88	high_impact	-0.98	medium_impact	0.52	0.8	14.38	17.44	0.28	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11874	11874	C	T	MI.18669	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1115	372	T	I	aCt/aTt	-0.66	0	0	probably_damaging	0.96	deleterious	0.04	neutral	4.48	neutral	-2.23	deleterious	-3.37	high_impact	3.92	0.73	neutral	0.53	neutral	2.57	19.95	deleterious	0.11	0.4	0.83	disease	0.65	disease	0.41	neutral	0.54	disease	1	0.99	deleterious	0.04	neutral	6	deleterious	0.76	deleterious	-2.01	low_impact	-0.57	medium_impact	2.75	high_impact	0.60	0.8	14.38	17.44	0.48	N	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8565	8565	A	C	MI.1867	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	200	67	Q	P	cAa/cCa	0.59	0	0	benign	0.06	neutral	0.2	neutral	1.64	deleterious	-3.52	deleterious	-3.71	low_impact	1.86	0.97	neutral	0.24	damaging	1.54	13.54	neutral	0.57262910	0.85	0.68	disease	0.12	neutral	0.49	neutral	0.21	neutral	6	0.78	neutral	0.57	deleterious	-6	neutral	0.23	neutral	0.38	medium_impact	-0.05	medium_impact	0.5	medium_impact	0.67	0.85	NA	NA	0.49	N	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11874	11874	C	A	MI.18670	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1115	372	T	N	aCt/aAt	-0.66	0	0	possibly_damaging	0.83	deleterious	0.04	neutral	4.42	deleterious	-4.61	deleterious	-2.74	high_impact	3.92	0.71	neutral	0.48	neutral	3.62	23.20	deleterious	0.23	0.45	0.47	neutral	0.65	disease	0.63	disease	0.7	disease	4	0.98	neutral	0.11	neutral	5	deleterious	0.71	deleterious	-1.37	low_impact	-0.57	medium_impact	2.75	high_impact	0.48	0.8	14.38	17.44	0.54	P	0.66	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	C11874A	LHON	+	-	Reported	1	.	P	P	damaging
chrM	11876	11876	A	C	MI.18671	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1117	373	I	L	Att/Ctt	-10.1	0	0	probably_damaging	1	neutral	1	neutral	4.89	neutral	0.49	neutral	-1.25	low_impact	1.08	0.63	neutral	0.1	damaging	1.14	11.45	neutral	0.21	0.45	0.48	neutral	0.41	neutral	0.23	neutral	0.43	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.64	deleterious	-3.54	low_impact	1.88	high_impact	-0.06	medium_impact	0.68	0.85	45.75	8.67	0.21	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11876	11876	A	G	MI.18672	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1117	373	I	V	Att/Gtt	-10.1	0	0	probably_damaging	1	neutral	0.29	neutral	4.66	neutral	0.6	neutral	-0.43	medium_impact	2	0.51	damaging	0.21	damaging	1.66	14.17	neutral	0.41	0.5	0.38	neutral	0.31	neutral	0.28	neutral	0.47	neutral	1	1	deleterious	0.15	neutral	1	deleterious	0.62	deleterious	-3.54	low_impact	-0.02	medium_impact	0.85	medium_impact	0.34	0.8	45.75	8.67	0.47	N	0.75	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11876	11876	A	T	MI.18673	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1117	373	I	F	Att/Ttt	-10.1	0	0	probably_damaging	1	neutral	0.07	neutral	4.65	neutral	-0.79	deleterious	-2.92	medium_impact	2.73	0.46	damaging	0.05	damaging	2.85	21.60	deleterious	0.17	0.45	0.67	disease	0.69	disease	0.51	disease	0.53	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.43	medium_impact	1.58	medium_impact	0.61	0.8	45.75	8.67	0.33	N	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11877	11877	T	C	MI.18674	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1118	373	I	T	aTt/aCt	4.86	0.95	0	probably_damaging	1	neutral	0.19	neutral	4.7	neutral	-0.54	deleterious	-2.66	low_impact	1.58	0.6	neutral	0.18	damaging	2.24	17.79	deleterious	0.1	0.4	0.43	neutral	0.43	neutral	0.34	neutral	0.46	neutral	1	1	deleterious	0.1	neutral	-2	neutral	0.68	deleterious	-3.54	low_impact	-0.15	medium_impact	0.44	medium_impact	0.21	0.8	45.75	8.67	0.53	P	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11877	11877	T	G	MI.18675	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1118	373	I	S	aTt/aGt	4.86	0.95	0	probably_damaging	1	deleterious	0.04	neutral	4.74	neutral	1.72	deleterious	-3.52	low_impact	1.82	0.4	damaging	0.09	damaging	4.29	24.00	deleterious	0.04	0.35	0.44	neutral	0.77	disease	0.54	disease	0.7	disease	4	1	deleterious	0.02	neutral	2	deleterious	0.73	deleterious	-3.54	low_impact	-0.57	medium_impact	0.68	medium_impact	0.17	0.8	45.75	8.67	0.63	P	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11877	11877	T	A	MI.18676	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1118	373	I	N	aTt/aAt	4.86	0.95	0	probably_damaging	1	deleterious	0.01	neutral	4.58	neutral	0.84	deleterious	-4.45	medium_impact	2.41	0.38	damaging	0.06	damaging	4.43	24.20	deleterious	0.09	0.35	0.83	disease	0.79	disease	0.61	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.54	low_impact	-0.92	medium_impact	1.26	medium_impact	0.13	0.8	45.75	8.67	0.66	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11878	11878	T	A	MI.18677	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1119	373	I	M	atT/atA	2.1	0.93	0	probably_damaging	1	neutral	0.25	neutral	4.63	neutral	-1.52	neutral	-1.75	low_impact	1.64	0.58	damaging	0.19	damaging	2.33	18.40	deleterious	0.25	0.45	0.72	disease	0.42	neutral	0.26	neutral	0.64	disease	3	1	deleterious	0.13	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	-0.07	medium_impact	0.5	medium_impact	0.63	0.8	45.75	8.67	0.41	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11878	11878	T	G	MI.18678	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1119	373	I	M	atT/atG	2.1	0.93	0	probably_damaging	1	neutral	0.25	neutral	4.63	neutral	-1.52	neutral	-1.75	low_impact	1.64	0.58	damaging	0.19	damaging	2.09	16.82	deleterious	0.25	0.45	0.72	disease	0.42	neutral	0.26	neutral	0.64	disease	3	1	deleterious	0.13	neutral	-2	neutral	0.73	deleterious	-3.54	low_impact	-0.07	medium_impact	0.5	medium_impact	0.63	0.8	45.75	8.67	0.42	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11879	11879	A	G	MI.18679	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1120	374	N	D	Aac/Gac	-8.95	0	0	probably_damaging	1	deleterious	0	neutral	4.55	neutral	-1.7	deleterious	-4.66	high_impact	4.53	0.69	neutral	0.14	damaging	3.97	23.60	deleterious	0.32	0.5	0.85	disease	0.8	disease	0.79	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.39	0.8	47.93	9.12	0.51	N	0.96	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8566	8566	A	C	MI.1868	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	201	67	Q	H	caA/caC	-0.8	0	0.01	benign	0.12	neutral	0.55	neutral	1.65	deleterious	-3.09	neutral	-2.14	low_impact	1.49	1	neutral	0.87	neutral	0.32	5.85	deleterious	0.79340444	0.85	0.6	disease	0.03	neutral	0.42	neutral	0.04	neutral	9	0.36	neutral	0.72	deleterious	-6	neutral	0.23	neutral	0.07	medium_impact	0.34	medium_impact	0.18	medium_impact	0.72	0.85	NA	NA	0.4	N	0.39	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11879	11879	A	T	MI.18680	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1120	374	N	Y	Aac/Tac	-8.95	0	0	probably_damaging	1	deleterious	0	neutral	4.55	neutral	-2.04	deleterious	-7.46	high_impact	4.17	0.65	neutral	0.12	damaging	3.80	23.40	deleterious	0.05	0.35	0.5	disease	0.88	disease	0.76	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	3	high_impact	0.23	0.8	47.93	9.12	0.42	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11879	11879	A	C	MI.18681	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1120	374	N	H	Aac/Cac	-8.95	0	0	probably_damaging	1	deleterious	0	neutral	4.53	neutral	-2.31	deleterious	-4.66	high_impact	4.17	0.63	neutral	0.11	damaging	3.21	22.70	deleterious	0.21	0.45	0.5	disease	0.85	disease	0.8	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	3	high_impact	0.28	0.8	47.93	9.12	0.44	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11880	11880	A	T	MI.18682	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1121	374	N	I	aAc/aTc	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.54	neutral	-0.58	deleterious	-8.4	high_impact	4.17	0.63	neutral	0.15	damaging	4.03	23.60	deleterious	0.06	0.35	0.48	neutral	0.9	disease	0.72	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	3	high_impact	0.12	0.8	47.93	9.12	0.63	P	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11880	11880	A	C	MI.18683	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1121	374	N	T	aAc/aCc	8.55	1	0	probably_damaging	1	deleterious	0.02	neutral	4.56	neutral	-0.45	deleterious	-5.59	high_impact	3.55	0.68	neutral	0.14	damaging	3.50	23.10	deleterious	0.17	0.45	0.54	disease	0.83	disease	0.64	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.75	medium_impact	2.39	high_impact	0.38	0.8	47.93	9.12	0.58	P	0.95	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11880	11880	A	G	MI.18684	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1121	374	N	S	aAc/aGc	8.55	1	0	probably_damaging	1	neutral	0.16	neutral	4.64	neutral	-0.22	deleterious	-4.66	medium_impact	2.55	0.63	neutral	0.19	damaging	3.22	22.70	deleterious	0.39	0.5	0.65	disease	0.81	disease	0.63	disease	0.61	disease	2	1	deleterious	0.08	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.2	medium_impact	1.4	medium_impact	0.32	0.8	47.93	9.12	0.6	P	0.85	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11881	11881	C	A	MI.18685	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1122	374	N	K	aaC/aaA	6.7	1	0	probably_damaging	1	deleterious	0	neutral	4.61	neutral	-0.82	deleterious	-5.59	high_impact	4.53	0.58	damaging	0.15	damaging	4.60	24.40	deleterious	0.21	0.45	0.74	disease	0.88	disease	0.78	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.50	0.8	47.93	9.12	0.66	P	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11881	11881	C	G	MI.18686	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1122	374	N	K	aaC/aaG	6.7	1	0	probably_damaging	1	deleterious	0	neutral	4.61	neutral	-0.82	deleterious	-5.59	high_impact	4.53	0.58	damaging	0.15	damaging	4.13	23.80	deleterious	0.21	0.45	0.74	disease	0.88	disease	0.78	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.36	high_impact	0.50	0.8	47.93	9.12	0.66	P	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11882	11882	C	A	MI.18687	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1123	375	L	M	Cta/Ata	-4.81	0	0	probably_damaging	1	neutral	0.06	neutral	4.51	deleterious	-3.11	neutral	-1.74	medium_impact	2.42	0.69	neutral	0.19	damaging	4.06	23.70	deleterious	0.2	0.45	0.51	disease	0.52	disease	0.38	neutral	0.46	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.47	medium_impact	1.27	medium_impact	0.49	0.8	45.53	8.73	0.36	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11882	11882	C	G	MI.18688	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1123	375	L	V	Cta/Gta	-4.81	0	0	probably_damaging	1	deleterious	0.02	neutral	4.53	neutral	-2	deleterious	-2.71	high_impact	4.29	0.65	neutral	0.13	damaging	3.54	23.10	deleterious	0.2	0.45	0.38	neutral	0.54	disease	0.58	disease	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.54	low_impact	-0.75	medium_impact	3.12	high_impact	0.58	0.8	45.53	8.73	0.42	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11883	11883	T	G	MI.18689	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1124	375	L	R	cTa/cGa	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	4.51	deleterious	-3.72	deleterious	-5.47	high_impact	4.29	0.67	neutral	0.11	damaging	4.34	24.00	deleterious	0.02	0.35	0.69	disease	0.84	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.12	high_impact	0.11	0.8	45.53	8.73	0.38	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8566	8566	A	T	MI.1869	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	201	67	Q	H	caA/caT	-0.8	0	0.01	benign	0.12	neutral	0.55	neutral	1.65	deleterious	-3.09	neutral	-2.14	low_impact	1.49	1	neutral	0.87	neutral	1.93	15.79	deleterious	0.79340444	0.85	0.6	disease	0.03	neutral	0.42	neutral	0.04	neutral	9	0.36	neutral	0.72	deleterious	-6	neutral	0.23	neutral	0.07	medium_impact	0.34	medium_impact	0.18	medium_impact	0.72	0.85	NA	NA	0.41	N	0.39	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11883	11883	T	A	MI.18690	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1124	375	L	Q	cTa/cAa	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	4.51	deleterious	-3.72	deleterious	-5.46	high_impact	4.29	0.63	neutral	0.12	damaging	4.23	23.90	deleterious	0.03	0.35	0.69	disease	0.81	disease	0.6	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.12	high_impact	0.33	0.8	45.53	8.73	0.35	N	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11883	11883	T	C	MI.18691	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1124	375	L	P	cTa/cCa	-1.35	0	0	probably_damaging	1	deleterious	0	neutral	4.5	deleterious	-4.4	deleterious	-6.41	high_impact	3.94	0.61	neutral	0.12	damaging	4.03	23.70	deleterious	0.02	0.35	0.76	disease	0.81	disease	0.73	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.77	high_impact	0.17	0.8	45.53	8.73	0.32	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11885	11885	C	A	MI.18692	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1126	376	L	M	Ctg/Atg	-7.57	0	0	benign	0.12	neutral	1	neutral	4.46	neutral	-1.72	neutral	0.44	neutral_impact	0.45	0.7	neutral	0.94	neutral	1.20	11.75	neutral	0.31	0.45	0.19	neutral	0.03	neutral	0.15	neutral	0.22	neutral	6	0.12	neutral	0.94	deleterious	-6	neutral	0.64	deleterious	0.1	medium_impact	1.88	high_impact	-0.68	medium_impact	0.52	0.8	25.93	16.52	0.39	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11885	11885	C	G	MI.18693	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1126	376	L	V	Ctg/Gtg	-7.57	0	0	benign	0.03	neutral	0.42	neutral	4.62	neutral	0.71	neutral	-0.4	neutral_impact	0.79	0.8	neutral	0.97	neutral	2.34	18.43	deleterious	0.27	0.45	0.28	neutral	0.27	neutral	0.25	neutral	0.45	neutral	1	0.56	neutral	0.7	deleterious	-6	neutral	0.68	deleterious	0.7	medium_impact	0.12	medium_impact	-0.34	medium_impact	0.49	0.8	25.93	16.52	0.4	N	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11886	11886	T	A	MI.18694	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1127	376	L	Q	cTg/cAg	0.95	0.1	0	possibly_damaging	0.87	deleterious	0	neutral	4.4	deleterious	-3.13	deleterious	-3.44	medium_impact	3.44	0.68	neutral	0.59	neutral	4.31	24.00	deleterious	0.05	0.35	0.66	disease	0.59	disease	0.58	disease	0.68	disease	4	1	deleterious	0.07	neutral	4	deleterious	0.80	deleterious	-1.49	low_impact	-1.48	low_impact	2.28	high_impact	0.20	0.8	25.93	16.52	0.45	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11886	11886	T	C	MI.18695	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1127	376	L	P	cTg/cCg	0.95	0.1	0	probably_damaging	0.93	deleterious	0	neutral	4.4	deleterious	-3.14	deleterious	-4.37	medium_impact	2.64	0.57	damaging	0.44	neutral	4.07	23.70	deleterious	0.04	0.35	0.72	disease	0.81	disease	0.71	disease	0.77	disease	5	1	deleterious	0.04	neutral	5	deleterious	0.88	deleterious	-1.77	low_impact	-1.48	low_impact	1.49	medium_impact	0.17	0.8	25.93	16.52	0.35	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11886	11886	T	G	MI.18696	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1127	376	L	R	cTg/cGg	0.95	0.1	0	possibly_damaging	0.87	deleterious	0	neutral	4.4	deleterious	-3.47	deleterious	-3.86	medium_impact	3.44	0.65	neutral	0.51	neutral	4.29	24.00	deleterious	0.03	0.35	0.64	disease	0.77	disease	0.7	disease	0.76	disease	5	1	deleterious	0.07	neutral	4	deleterious	0.85	deleterious	-1.49	low_impact	-1.48	low_impact	2.28	high_impact	0.11	0.8	25.93	16.52	0.4	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11888	11888	G	C	MI.18697	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1129	377	G	R	Gga/Cga	-4.12	0	0	probably_damaging	1	deleterious	0	neutral	4.44	deleterious	-4.88	deleterious	-7.25	high_impact	4.34	0.68	neutral	0.29	neutral	4.03	23.60	deleterious	0.01	0.35	0.65	disease	0.89	disease	0.74	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	3.17	high_impact	0.36	0.8	45.75	8.66	0.41	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11888	11888	G	T	MI.18698	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1129	377	G	W	Gga/Tga	-4.12	0	0	probably_damaging	1	deleterious	0	neutral	4.41	deleterious	-7.41	deleterious	-7.31	high_impact	4.34	0.65	neutral	0.28	damaging	4.54	24.30	deleterious	0.02	0.35	0.82	disease	0.89	disease	0.69	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	3.17	high_impact	0.15	0.8	45.75	8.66	0.36	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11889	11889	G	C	MI.18699	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1130	377	G	A	gGa/gCa	7.17	1	0	probably_damaging	1	neutral	0.13	neutral	4.56	neutral	-1.33	deleterious	-5.34	low_impact	1.64	0.66	neutral	0.54	neutral	3.23	22.80	deleterious	0.1	0.4	0.34	neutral	0.49	neutral	0.36	neutral	0.43	neutral	2	1	deleterious	0.07	neutral	-2	neutral	0.76	deleterious	-3.54	low_impact	-0.26	medium_impact	0.5	medium_impact	0.42	0.8	45.75	8.66	0.59	P	0.76	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8614	8614	T	A	MI.187	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	88	30	L	M	Ttg/Atg	-20	0	0.01	probably_damaging	1	neutral	0.1	neutral	4.22	neutral	-2.21	neutral	-1.35	low_impact	1.92	0.91	neutral	0.9	neutral	2.26	17.92	deleterious	0.32	0.65	0.6	disease	0.26	neutral	0.19	neutral	0.54	disease	1	1	deleterious	0.05	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	-0.25	medium_impact	0.55	medium_impact	0.66	0.9	17.7	14.1	0.52	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8567	8567	T	A	MI.1870	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	202	68	S	T	Tcc/Acc	-4.27	0	0	possibly_damaging	0.85	neutral	0.4	neutral	1.7	neutral	-1.87	neutral	-0.6	low_impact	1.54	0.96	neutral	0.42	neutral	4.28	24.00	deleterious	0.39834806	0.85	NA	NA	0.05	neutral	0.71	disease	0.16	neutral	7	0.85	neutral	0.28	neutral	-3	neutral	0.76	deleterious	-1.47	low_impact	0.19	medium_impact	0.22	medium_impact	0.84	0.90	NA	NA	0.47	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11889	11889	G	A	MI.18700	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1130	377	G	E	gGa/gAa	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-4.34	deleterious	-7.23	high_impact	4.34	0.67	neutral	0.36	neutral	4.00	23.60	deleterious	0.02	0.35	0.66	disease	0.88	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.17	high_impact	0.17	0.8	45.75	8.66	0.62	P	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11889	11889	G	T	MI.18701	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1130	377	G	V	gGa/gTa	7.17	1	0	probably_damaging	1	deleterious	0.01	neutral	4.47	deleterious	-4.48	deleterious	-8.15	high_impact	4	0.67	neutral	0.41	neutral	3.98	23.60	deleterious	0.02	0.35	0.22	neutral	0.86	disease	0.65	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	2.83	high_impact	0.13	0.8	45.75	8.66	0.57	P	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11891	11891	G	A	MI.18702	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1132	378	E	K	Gaa/Aaa	-1.12	0	0	probably_damaging	1	deleterious	0.01	neutral	5.16	neutral	1.64	deleterious	-3.73	high_impact	4.64	0.33	damaging	0.07	damaging	4.61	24.40	deleterious	0.13	0.4	0.79	disease	0.83	disease	0.76	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-0.92	medium_impact	3.46	high_impact	0.73	0.85	47.06	9.14	0.67	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11891	11891	G	C	MI.18703	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1132	378	E	Q	Gaa/Caa	-1.12	0	0	probably_damaging	1	deleterious	0	neutral	4.36	neutral	-2.89	deleterious	-2.8	high_impact	4.64	0.36	damaging	0.07	damaging	3.53	23.10	deleterious	0.14	0.4	0.81	disease	0.73	disease	0.72	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.39	0.8	47.06	9.14	0.63	P	0.92	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11892	11892	A	G	MI.18704	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1133	378	E	G	gAa/gGa	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.34	deleterious	-3.84	deleterious	-6.54	high_impact	4.3	0.36	damaging	0.12	damaging	4.33	24.00	deleterious	0.07	0.35	0.87	disease	0.7	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	3.13	high_impact	0.14	0.8	47.06	9.14	0.78	P	0.53	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11892	11892	A	T	MI.18705	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1133	378	E	V	gAa/gTa	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.33	deleterious	-4.37	deleterious	-6.54	high_impact	4.64	0.35	damaging	0.08	damaging	4.20	23.90	deleterious	0.05	0.35	0.86	disease	0.83	disease	0.73	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.26	0.8	47.06	9.14	0.77	P	0.80	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11892	11892	A	C	MI.18706	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1133	378	E	A	gAa/gCa	7.17	1	0	probably_damaging	1	deleterious	0	neutral	4.36	deleterious	-3.07	deleterious	-5.6	high_impact	4.64	0.39	damaging	0.13	damaging	3.74	23.30	deleterious	0.07	0.35	0.68	disease	0.66	disease	0.71	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.32	0.8	47.06	9.14	0.8	P	0.74	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11893	11893	A	C	MI.18707	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1134	378	E	D	gaA/gaC	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.37	neutral	-2.73	deleterious	-2.8	high_impact	4.64	0.33	damaging	0.07	damaging	3.79	23.40	deleterious	0.15	0.4	0.87	disease	0.68	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.40	0.8	47.06	9.14	0.79	P	0.89	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11893	11893	A	T	MI.18708	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1134	378	E	D	gaA/gaT	8.55	1	0	probably_damaging	1	deleterious	0	neutral	4.37	neutral	-2.73	deleterious	-2.8	high_impact	4.64	0.33	damaging	0.07	damaging	3.89	23.50	deleterious	0.15	0.4	0.87	disease	0.68	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	3.46	high_impact	0.40	0.8	47.06	9.14	0.79	P	0.89	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11894	11894	C	A	MI.18709	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1135	379	L	I	Ctc/Atc	0.49	0.03	0	probably_damaging	1	neutral	0.82	neutral	4.58	neutral	-1.29	neutral	-1.65	low_impact	1	0.77	neutral	0.39	neutral	3.21	22.70	deleterious	0.3	0.45	0.7	disease	0.15	neutral	0.19	neutral	0.38	neutral	2	1	deleterious	0.41	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.57	medium_impact	-0.14	medium_impact	0.56	0.8	47.49	8.78	0.27	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8567	8567	T	G	MI.1871	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	202	68	S	A	Tcc/Gcc	-4.27	0	0	possibly_damaging	0.78	neutral	0.52	neutral	1.76	neutral	-1.14	neutral	-0.75	low_impact	1.54	1	neutral	0.21	damaging	3.68	23.30	deleterious	0.48392560	0.85	NA	NA	0.04	neutral	0.66	disease	0.16	neutral	7	0.75	neutral	0.37	neutral	-3	neutral	0.63	deleterious	-1.28	low_impact	0.31	medium_impact	0.22	medium_impact	0.75	0.85	NA	NA	0.43	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11894	11894	C	T	MI.18710	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1135	379	L	F	Ctc/Ttc	0.49	0.03	0	probably_damaging	1	neutral	0.29	neutral	4.67	neutral	0.59	deleterious	-3.42	low_impact	1.77	0.69	neutral	0.17	damaging	4.04	23.70	deleterious	0.24	0.45	0.82	disease	0.59	disease	0.4	neutral	0.53	disease	1	1	deleterious	0.15	neutral	-2	neutral	0.78	deleterious	-3.54	low_impact	-0.02	medium_impact	0.63	medium_impact	0.45	0.8	47.49	8.78	0.3	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11894	11894	C	G	MI.18711	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1135	379	L	V	Ctc/Gtc	0.49	0.03	0	probably_damaging	1	neutral	0.19	neutral	4.56	neutral	-1.31	deleterious	-2.54	medium_impact	2.12	0.72	neutral	0.2	damaging	3.52	23.10	deleterious	0.29	0.45	0.66	disease	0.45	neutral	0.41	neutral	0.6	disease	2	1	deleterious	0.1	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.15	medium_impact	0.97	medium_impact	0.61	0.8	47.49	8.78	0.39	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11895	11895	T	C	MI.18712	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1136	379	L	P	cTc/cCc	-2.04	0	0	probably_damaging	1	deleterious	0	neutral	4.46	deleterious	-4.53	deleterious	-6.3	high_impact	4.07	0.59	damaging	0.13	damaging	4.09	23.70	deleterious	0.02	0.35	0.88	disease	0.8	disease	0.69	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.9	high_impact	0.15	0.8	47.49	8.78	0.29	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11895	11895	T	A	MI.18713	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1136	379	L	H	cTc/cAc	-2.04	0	0	probably_damaging	1	deleterious	0	neutral	4.48	deleterious	-4.03	deleterious	-6.25	high_impact	4.07	0.68	neutral	0.11	damaging	4.47	24.20	deleterious	0.04	0.35	0.74	disease	0.77	disease	0.64	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.9	high_impact	0.17	0.8	47.49	8.78	0.29	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11895	11895	T	G	MI.18714	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1136	379	L	R	cTc/cGc	-2.04	0	0	probably_damaging	1	deleterious	0	neutral	4.47	deleterious	-3.61	deleterious	-5.4	high_impact	4.07	0.58	damaging	0.12	damaging	4.34	24.10	deleterious	0.02	0.35	0.75	disease	0.82	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	2.9	high_impact	0.08	0.8	47.49	8.78	0.29	N	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11897	11897	T	C	MI.18715	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1138	380	S	P	Tct/Cct	-0.43	0	0	possibly_damaging	0.45	deleterious	0.03	neutral	4.59	neutral	-1.53	neutral	-1.34	low_impact	1.92	0.61	neutral	0.45	neutral	3.66	23.20	deleterious	0.05	0.35	0.69	disease	0.7	disease	0.56	disease	0.7	disease	4	0.97	neutral	0.29	neutral	1	deleterious	0.56	deleterious	-0.64	medium_impact	-0.64	medium_impact	0.77	medium_impact	0.30	0.8	23.97	19.12	0.35	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11897	11897	T	A	MI.18716	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1138	380	S	T	Tct/Act	-0.43	0	0	benign	0.1	neutral	0.37	neutral	4.65	neutral	0.11	neutral	0.62	neutral_impact	0.04	0.7	neutral	0.77	neutral	0.46	7.15	deleterious	0.28	0.45	0.5	neutral	0.07	neutral	0.11	neutral	0.21	neutral	6	0.58	neutral	0.64	deleterious	-6	neutral	0.28	neutral	0.18	medium_impact	0.07	medium_impact	-1.09	low_impact	0.48	0.8	23.97	19.12	0.56	P	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11897	11897	T	G	MI.18717	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1138	380	S	A	Tct/Gct	-0.43	0	0	benign	0.05	neutral	0.13	neutral	4.66	neutral	0.34	neutral	0.16	low_impact	1.46	0.74	neutral	0.86	neutral	0.86	9.83	deleterious	0.35	0.5	0.53	disease	0.17	neutral	0.3	neutral	0.31	neutral	4	0.86	neutral	0.54	deleterious	-6	neutral	0.19	neutral	0.48	medium_impact	-0.26	medium_impact	0.32	medium_impact	0.44	0.8	23.97	19.12	0.52	P	0.26	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11898	11898	C	T	MI.18718	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1139	380	S	F	tCt/tTt	-0.2	0	0	benign	0	neutral	0.71	neutral	4.65	neutral	0.05	neutral	2.01	neutral_impact	-0.39	0.8	neutral	0.96	neutral	0.30	5.72	deleterious	0.06	0.35	0.64	disease	0.34	neutral	0.2	neutral	0.61	disease	2	0.28	neutral	0.86	deleterious	-6	neutral	0.17	neutral	2.1	high_impact	0.42	medium_impact	-1.51	low_impact	0.12	0.8	23.97	19.12	0.24	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11898	11898	C	G	MI.18719	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1139	380	S	C	tCt/tGt	-0.2	0	0	possibly_damaging	0.76	deleterious	0.03	neutral	4.58	neutral	-2.32	neutral	-0.09	low_impact	1.72	0.73	neutral	0.42	neutral	3.48	23.10	deleterious	0.07	0.35	0.92	disease	0.49	neutral	0.4	neutral	0.69	disease	4	0.98	neutral	0.14	neutral	1	deleterious	0.65	deleterious	-1.19	low_impact	-0.64	medium_impact	0.58	medium_impact	0.23	0.8	23.97	19.12	0.45	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8567	8567	T	C	MI.1872	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	202	68	S	P	Tcc/Ccc	-4.27	0	0	probably_damaging	0.94	neutral	0.21	neutral	1.64	deleterious	-3.23	neutral	-1.25	low_impact	1.54	0.99	neutral	0.11	damaging	4.14	23.80	deleterious	0.52918828	0.85	NA	NA	0.1	neutral	0.69	disease	0.19	neutral	6	0.96	neutral	0.14	neutral	-2	neutral	0.82	deleterious	-1.89	low_impact	-0.03	medium_impact	0.22	medium_impact	0.55	0.85	NA	NA	0.47	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11898	11898	C	A	MI.18720	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1139	380	S	Y	tCt/tAt	-0.2	0	0	benign	0.11	neutral	0.23	neutral	4.72	neutral	0.99	neutral	0.91	low_impact	1.2	0.77	neutral	0.67	neutral	2.20	17.50	deleterious	0.06	0.35	0.83	disease	0.44	neutral	0.24	neutral	0.66	disease	3	0.74	neutral	0.56	deleterious	-6	neutral	0.28	neutral	0.14	medium_impact	-0.09	medium_impact	0.06	medium_impact	0.21	0.8	23.97	19.12	0.38	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11900	11900	G	A	MI.18721	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1141	381	V	M	Gtg/Atg	-9.18	0	0	probably_damaging	0.95	neutral	0.09	neutral	4.37	neutral	-2.6	neutral	-2.01	low_impact	0.99	0.75	neutral	0.54	neutral	3.84	23.40	deleterious	0.13	0.4	0.75	disease	0.58	disease	0.33	neutral	0.5	disease	0	0.98	deleterious	0.07	neutral	-2	neutral	0.76	deleterious	-1.92	low_impact	-0.36	medium_impact	-0.15	medium_impact	0.89	0.9	27.02	19.58	0.34	N	0.49	polymorphism	1	0.02	.	.	.	.	.	breast tumor	COSM1138236	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11900	11900	G	C	MI.18722	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1141	381	V	L	Gtg/Ctg	-9.18	0	0	possibly_damaging	0.49	neutral	0.66	neutral	4.63	neutral	-0.53	neutral	-1.38	neutral_impact	0.27	0.72	neutral	0.68	neutral	3.79	23.40	deleterious	0.16	0.45	0.51	disease	0.44	neutral	0.19	neutral	0.35	neutral	3	0.41	neutral	0.59	deleterious	-3	neutral	0.71	deleterious	-0.7	medium_impact	0.36	medium_impact	-0.86	medium_impact	0.52	0.8	27.02	19.58	0.35	N	0.56	polymorphism	1	0.02	rs878983346	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11900	11900	G	T	MI.18723	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1141	381	V	L	Gtg/Ttg	-9.18	0	0	possibly_damaging	0.49	neutral	0.66	neutral	4.63	neutral	-0.53	neutral	-1.38	neutral_impact	0.27	0.72	neutral	0.68	neutral	3.89	23.50	deleterious	0.16	0.45	0.51	disease	0.44	neutral	0.19	neutral	0.35	neutral	3	0.41	neutral	0.59	deleterious	-3	neutral	0.71	deleterious	-0.7	medium_impact	0.36	medium_impact	-0.86	medium_impact	0.52	0.8	27.02	19.58	0.35	N	0.56	polymorphism	1	0.02	rs878983346	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11901	11901	T	C	MI.18724	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1142	381	V	A	gTg/gCg	1.18	0.75	0	possibly_damaging	0.62	neutral	0.08	neutral	4.41	neutral	-1.81	deleterious	-3.43	low_impact	1	0.67	neutral	0.75	neutral	3.63	23.20	deleterious	0.06	0.35	0.48	neutral	0.51	disease	0.29	neutral	0.46	neutral	1	0.92	neutral	0.23	neutral	-3	neutral	0.73	deleterious	-0.92	medium_impact	-0.39	medium_impact	-0.14	medium_impact	0.17	0.8	27.02	19.58	0.4	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11901	11901	T	G	MI.18725	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1142	381	V	G	gTg/gGg	1.18	0.75	0	possibly_damaging	0.9	deleterious	0	neutral	4.34	deleterious	-4.19	deleterious	-6.14	medium_impact	2.6	0.7	neutral	0.46	neutral	3.89	23.50	deleterious	0.02	0.35	0.73	disease	0.73	disease	0.51	disease	0.58	disease	2	1	deleterious	0.05	neutral	4	deleterious	0.79	deleterious	-1.61	low_impact	-1.48	low_impact	1.45	medium_impact	0.20	0.8	27.02	19.58	0.38	N	0.95	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11901	11901	T	A	MI.18726	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1142	381	V	E	gTg/gAg	1.18	0.75	0	probably_damaging	0.94	deleterious	0	neutral	4.34	deleterious	-4.69	deleterious	-5.21	medium_impact	2.94	0.68	neutral	0.44	neutral	4.72	24.60	deleterious	0.02	0.35	0.66	disease	0.89	disease	0.61	disease	0.8	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.86	deleterious	-1.84	low_impact	-1.48	low_impact	1.78	medium_impact	0.18	0.8	27.02	19.58	0.36	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11903	11903	C	A	MI.18727	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1144	382	L	M	Cta/Ata	-2.96	0	0	benign	0.12	neutral	0.42	neutral	3.64	deleterious	-4.5	neutral	-0.33	neutral_impact	-0.12	0.74	neutral	0.96	neutral	2.50	19.47	deleterious	0.23	0.45	0.59	disease	0.1	neutral	0.16	neutral	0.4	neutral	2	0.51	neutral	0.65	deleterious	-6	neutral	0.67	deleterious	0.1	medium_impact	0.12	medium_impact	-1.25	low_impact	0.55	0.8	23.53	17.78	0.42	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11903	11903	C	G	MI.18728	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1144	382	L	V	Cta/Gta	-2.96	0	0	benign	0.01	neutral	0.21	neutral	3.63	deleterious	-4.73	neutral	0.52	neutral_impact	0.4	0.83	neutral	0.97	neutral	2.25	17.82	deleterious	0.21	0.45	0.42	neutral	0.34	neutral	0.23	neutral	0.47	neutral	1	0.78	neutral	0.6	deleterious	-6	neutral	0.66	deleterious	1.16	medium_impact	-0.12	medium_impact	-0.73	medium_impact	0.54	0.8	23.53	17.78	0.43	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11904	11904	T	G	MI.18729	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1145	382	L	R	cTa/cGa	0.03	0	0	possibly_damaging	0.87	deleterious	0	neutral	3.58	deleterious	-8.2	deleterious	-4.09	medium_impact	2.87	0.67	neutral	0.5	neutral	4.32	24.00	deleterious	0.02	0.35	0.76	disease	0.84	disease	0.66	disease	0.8	disease	6	1	deleterious	0.07	neutral	4	deleterious	0.83	deleterious	-1.49	low_impact	-1.48	low_impact	1.71	medium_impact	0.15	0.8	23.53	17.78	0.34	N	0.75	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8568	8568	C	T	MI.1873	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	203	68	S	F	tCc/tTc	1.75	0.01	0	probably_damaging	0.97	neutral	0.7	neutral	1.63	deleterious	-3.57	neutral	-0.68	neutral_impact	-0.04	0.99	neutral	0.14	damaging	4.34	24.00	deleterious	0.56070775	0.85	NA	NA	0.07	neutral	0.7	disease	0.18	neutral	6	0.97	neutral	0.37	neutral	-2	neutral	0.87	deleterious	-2.19	low_impact	0.5	medium_impact	-1.13	low_impact	0.52	0.85	NA	NA	0.41	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11904	11904	T	A	MI.18730	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1145	382	L	Q	cTa/cAa	0.03	0	0	possibly_damaging	0.87	deleterious	0	neutral	3.58	deleterious	-8.01	deleterious	-3.85	medium_impact	2.52	0.69	neutral	0.59	neutral	4.28	24.00	deleterious	0.03	0.35	0.7	disease	0.64	disease	0.53	disease	0.63	disease	3	1	deleterious	0.07	neutral	4	deleterious	0.76	deleterious	-1.49	low_impact	-1.48	low_impact	1.37	medium_impact	0.27	0.8	23.53	17.78	0.4	N	0.68	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11904	11904	T	C	MI.18731	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1145	382	L	P	cTa/cCa	0.03	0	0	probably_damaging	0.93	deleterious	0	neutral	3.58	deleterious	-8.51	deleterious	-4.2	medium_impact	2.87	0.62	neutral	0.43	neutral	4.04	23.70	deleterious	0.02	0.35	0.7	disease	0.87	disease	0.68	disease	0.81	disease	6	1	deleterious	0.04	neutral	5	deleterious	0.79	deleterious	-1.77	low_impact	-1.48	low_impact	1.71	medium_impact	0.28	0.8	23.53	17.78	0.34	N	0.85	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11906	11906	G	A	MI.18732	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1147	383	V	M	Gta/Ata	-7.57	0	0	benign	0.03	neutral	0.61	neutral	4.61	neutral	-0.49	neutral	0.08	neutral_impact	-0.06	0.76	neutral	0.93	neutral	-0.05	2.15	deleterious	0.29	0.45	0.8	disease	0.28	neutral	0.19	neutral	0.59	disease	2	0.34	neutral	0.79	deleterious	-6	neutral	0.19	neutral	0.7	medium_impact	0.31	medium_impact	-1.19	low_impact	0.96	1	26.58	19.2	0.32	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11906	11906	G	C	MI.18733	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1147	383	V	L	Gta/Cta	-7.57	0	0	benign	0.01	neutral	0.83	neutral	4.68	neutral	-1.04	neutral	-0.26	neutral_impact	-0.01	0.78	neutral	0.91	neutral	0.48	7.31	deleterious	0.2	0.45	0.81	disease	0.46	neutral	0.23	neutral	0.65	disease	3	0.15	neutral	0.91	deleterious	-6	neutral	0.23	neutral	1.16	medium_impact	0.59	medium_impact	-1.14	low_impact	0.64	0.8	26.58	19.2	0.24	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11906	11906	G	T	MI.18734	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1147	383	V	L	Gta/Tta	-7.57	0	0	benign	0.01	neutral	0.83	neutral	4.68	neutral	-1.04	neutral	-0.26	neutral_impact	-0.01	0.78	neutral	0.91	neutral	0.64	8.46	deleterious	0.2	0.45	0.81	disease	0.46	neutral	0.23	neutral	0.65	disease	3	0.15	neutral	0.91	deleterious	-6	neutral	0.23	neutral	1.16	medium_impact	0.59	medium_impact	-1.14	low_impact	0.64	0.8	26.58	19.2	0.24	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11907	11907	T	A	MI.18735	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1148	383	V	E	gTa/gAa	0.03	0	0	benign	0.34	neutral	0.2	neutral	4.75	deleterious	-3.98	neutral	-2.47	medium_impact	2.71	0.74	neutral	0.51	neutral	3.01	22.30	deleterious	0.05	0.35	0.96	disease	0.83	disease	0.66	disease	0.83	disease	7	0.76	neutral	0.43	neutral	-3	neutral	0.41	neutral	-0.45	medium_impact	-0.14	medium_impact	1.56	medium_impact	0.18	0.8	26.58	19.2	0.3	N	0.57	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11907	11907	T	C	MI.18736	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1148	383	V	A	gTa/gCa	0.03	0	0	benign	0.01	neutral	0.48	neutral	4.69	neutral	-1.47	neutral	-1.15	low_impact	1.12	0.73	neutral	0.85	neutral	0.63	8.40	deleterious	0.15	0.45	0.77	disease	0.36	neutral	0.4	neutral	0.65	disease	3	0.51	neutral	0.74	deleterious	-6	neutral	0.23	neutral	1.16	medium_impact	0.18	medium_impact	-0.02	medium_impact	0.25	0.8	26.58	19.2	0.35	N	0.24	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11907	11907	T	G	MI.18737	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1148	383	V	G	gTa/gGa	0.03	0	0	benign	0.18	neutral	0.32	neutral	4.62	neutral	0.67	deleterious	-3.29	low_impact	1.06	0.71	neutral	0.51	neutral	2.05	16.55	deleterious	0.05	0.35	0.73	disease	0.6	disease	0.55	disease	0.7	disease	4	0.62	neutral	0.57	deleterious	-6	neutral	0.31	neutral	-0.1	medium_impact	0.02	medium_impact	-0.08	medium_impact	0.16	0.8	26.58	19.2	0.3	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11909	11909	A	T	MI.18738	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1150	384	T	S	Acc/Tcc	-3.89	0	0	benign	0.02	neutral	1	neutral	2.42	neutral	-0.56	neutral	1.1	neutral_impact	-1.12	0.76	neutral	0.99	neutral	-1.19	0.01	neutral	0.32	0.5	0.56	disease	0.08	neutral	0.17	neutral	0.35	neutral	3	0.02	neutral	0.99	deleterious	-6	neutral	0.14	neutral	0.87	medium_impact	1.88	high_impact	-2.23	low_impact	0.74	0.85	16.99	18.59	0.38	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11909	11909	A	C	MI.18739	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1150	384	T	P	Acc/Ccc	-3.89	0	0	possibly_damaging	0.55	deleterious	0	neutral	2.24	deleterious	-4.57	neutral	-2.35	medium_impact	2.14	0.77	neutral	0.5	neutral	1.83	15.14	deleterious	0.04	0.35	0.92	disease	0.88	disease	0.69	disease	0.86	disease	7	1	deleterious	0.23	neutral	4	deleterious	0.49	deleterious	-0.8	medium_impact	-1.48	low_impact	0.99	medium_impact	0.37	0.8	16.99	18.59	0.28	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8568	8568	C	G	MI.1874	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	203	68	S	C	tCc/tGc	1.75	0.01	0	probably_damaging	0.98	neutral	0.18	neutral	1.62	deleterious	-4.03	neutral	-1.25	low_impact	1.54	0.98	neutral	0.11	damaging	3.74	23.30	deleterious	0.57564883	0.85	NA	NA	0.05	neutral	0.68	disease	0.16	neutral	7	0.99	deleterious	0.1	neutral	-2	neutral	0.88	deleterious	-2.36	low_impact	-0.08	medium_impact	0.22	medium_impact	0.63	0.85	NA	NA	0.49	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11909	11909	A	G	MI.18740	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1150	384	T	A	Acc/Gcc	-3.89	0	0	benign	0.01	neutral	0.3	neutral	2.49	neutral	-2.16	neutral	-0.05	neutral_impact	-0.82	0.8	neutral	0.98	neutral	-0.06	2.08	deleterious	0.22	0.45	0.58	disease	0.25	neutral	0.25	neutral	0.55	disease	1	0.7	neutral	0.65	deleterious	-6	neutral	0.16	neutral	1.16	medium_impact	0	medium_impact	-1.94	low_impact	0.33	0.8	16.99	18.59	0.38	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	COSM1155515	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11910	11910	C	T	MI.18741	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1151	384	T	I	aCc/aTc	-2.04	0	0	benign	0.02	deleterious	0.01	neutral	2.24	neutral	-1.58	deleterious	-2.87	low_impact	1.51	0.76	neutral	0.51	neutral	2.18	17.38	deleterious	0.08	0.35	0.67	disease	0.71	disease	0.53	disease	0.64	disease	3	0.99	deleterious	0.5	deleterious	-2	neutral	0.33	neutral	0.87	medium_impact	-0.92	medium_impact	0.37	medium_impact	0.66	0.8	16.99	18.59	0.29	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11910	11910	C	A	MI.18742	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1151	384	T	N	aCc/aAc	-2.04	0	0	benign	0.26	neutral	0.06	neutral	2.28	deleterious	-3.43	neutral	-1.32	low_impact	1.25	0.71	neutral	0.53	neutral	2.14	17.11	deleterious	0.23	0.45	0.89	disease	0.75	disease	0.55	disease	0.76	disease	5	0.93	neutral	0.4	neutral	-6	neutral	0.43	neutral	-0.29	medium_impact	-0.47	medium_impact	0.11	medium_impact	0.56	0.8	16.99	18.59	0.32	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11910	11910	C	G	MI.18743	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1151	384	T	S	aCc/aGc	-2.04	0	0	benign	0.02	neutral	1	neutral	2.42	neutral	-0.56	neutral	1.1	neutral_impact	-1.12	0.76	neutral	0.99	neutral	-1.01	0.02	neutral	0.32	0.5	0.56	disease	0.08	neutral	0.17	neutral	0.35	neutral	3	0.02	neutral	0.99	deleterious	-6	neutral	0.14	neutral	0.87	medium_impact	1.88	high_impact	-2.23	low_impact	0.74	0.85	16.99	18.59	0.37	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11912	11912	A	T	MI.18744	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1153	385	T	S	Acg/Tcg	-1.12	0	0	benign	0.01	neutral	0.16	neutral	2.31	neutral	0.32	neutral	-0.01	neutral_impact	0.14	0.8	neutral	0.99	neutral	-0.45	0.29	neutral	0.42	0.55	0.51	disease	0.25	neutral	0.22	neutral	0.34	neutral	3	0.84	neutral	0.58	deleterious	-6	neutral	0.14	neutral	1.16	medium_impact	-0.2	medium_impact	-0.99	medium_impact	0.74	0.85	13.29	16.64	0.44	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11912	11912	A	C	MI.18745	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1153	385	T	P	Acg/Ccg	-1.12	0	0	possibly_damaging	0.55	deleterious	0	neutral	2.16	neutral	3.82	deleterious	-2.55	low_impact	1.28	0.66	neutral	0.42	neutral	1.81	15.05	deleterious	0.04	0.35	0.83	disease	0.8	disease	0.65	disease	0.81	disease	6	1	deleterious	0.23	neutral	1	deleterious	0.46	deleterious	-0.8	medium_impact	-1.48	low_impact	0.14	medium_impact	0.41	0.8	13.29	16.64	0.29	N	0.57	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11912	11912	A	G	MI.18746	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1153	385	T	A	Acg/Gcg	-1.12	0	0	benign	0.08	neutral	0.18	neutral	2.49	neutral	0.29	neutral	-0.91	neutral_impact	0.24	0.72	neutral	0.96	neutral	0.46	7.16	deleterious	0.27	0.45	0.63	disease	0.33	neutral	0.52	disease	0.62	disease	2	0.8	neutral	0.55	deleterious	-6	neutral	0.15	neutral	0.28	medium_impact	-0.17	medium_impact	-0.89	medium_impact	0.28	0.8	13.29	16.64	0.43	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11913	11913	C	A	MI.18747	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1154	385	T	K	aCg/aAg	-2.73	0	0	benign	0.18	deleterious	0	neutral	2.18	neutral	4.23	neutral	-1.87	low_impact	1.28	0.7	neutral	0.51	neutral	2.74	21.10	deleterious	0.04	0.35	0.85	disease	0.63	disease	0.63	disease	0.75	disease	5	1	deleterious	0.41	neutral	-2	neutral	0.30	neutral	-0.1	medium_impact	-1.48	low_impact	0.14	medium_impact	0.46	0.8	13.29	16.64	0.31	N	0.37	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11913	11913	C	T	MI.18748	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1154	385	T	M	aCg/aTg	-2.73	0	0	benign	0.05	neutral	0.34	neutral	2.2	neutral	-1.71	neutral	-0.66	neutral_impact	-0.14	0.65	neutral	0.97	neutral	0.63	8.34	deleterious	0.13	0.4	0.54	disease	0.25	neutral	0.2	neutral	0.52	disease	0	0.63	neutral	0.65	deleterious	-6	neutral	0.14	neutral	0.48	medium_impact	0.04	medium_impact	-1.26	low_impact	0.57	0.8	13.29	16.64	0.48	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11915	11915	T	C	MI.18749	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1156	386	F	L	Ttc/Ctc	-2.96	0	0	probably_damaging	1	neutral	0.47	neutral	2.16	neutral	2.77	deleterious	-5.45	medium_impact	2.28	0.77	neutral	0.21	damaging	4.14	23.80	deleterious	0.21	0.45	0.59	disease	0.72	disease	0.36	neutral	0.53	disease	1	0.99	deleterious	0.24	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	0.17	medium_impact	1.13	medium_impact	0.60	0.8	46.62	8.86	0.32	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8568	8568	C	A	MI.1875	MT-ATP8	V	ENSG00000228253	ENSP00000355265	ENST00000361851	ATP8_HUMAN	P03928	4509	YP_003024030.1	203	68	S	Y	tCc/tAc	1.75	0.01	0	probably_damaging	0.97	neutral	1	neutral	1.62	deleterious	-3.7	neutral	-0.77	low_impact	0.86	0.99	neutral	0.13	damaging	4.37	24.10	deleterious	0.55484047	0.85	NA	NA	0.09	neutral	0.7	disease	0.18	neutral	6	0.97	neutral	0.52	deleterious	-2	neutral	0.87	deleterious	-2.19	low_impact	1.98	high_impact	-0.36	medium_impact	0.61	0.85	NA	NA	0.35	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11915	11915	T	G	MI.18750	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1156	386	F	V	Ttc/Gtc	-2.96	0	0	probably_damaging	1	neutral	0.4	neutral	2.1	neutral	1.39	deleterious	-6.35	medium_impact	2.82	0.71	neutral	0.15	damaging	4.23	23.90	deleterious	0.09	0.35	0.53	disease	0.74	disease	0.54	disease	0.53	disease	1	1	deleterious	0.2	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.1	medium_impact	1.66	medium_impact	0.32	0.8	46.62	8.86	0.31	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11915	11915	T	A	MI.18751	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1156	386	F	I	Ttc/Atc	-2.96	0	0	probably_damaging	1	neutral	0.41	neutral	2.11	neutral	0.84	deleterious	-5.46	medium_impact	2.82	0.8	neutral	0.2	damaging	4.52	24.30	deleterious	0.19	0.45	0.5	neutral	0.71	disease	0.32	neutral	0.49	neutral	0	1	deleterious	0.21	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	0.11	medium_impact	1.66	medium_impact	0.54	0.8	46.62	8.86	0.31	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11916	11916	T	A	MI.18752	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1157	386	F	Y	tTc/tAc	4.63	1	0	probably_damaging	1	neutral	0.22	neutral	2.04	neutral	-2.29	deleterious	-2.51	medium_impact	2.45	0.75	neutral	0.21	damaging	4.34	24.00	deleterious	0.21	0.45	0.61	disease	0.7	disease	0.34	neutral	0.53	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.11	medium_impact	1.3	medium_impact	0.59	0.8	46.62	8.86	0.56	P	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11916	11916	T	G	MI.18753	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1157	386	F	C	tTc/tGc	4.63	1	0	probably_damaging	1	neutral	0.07	neutral	1.97	neutral	1.16	deleterious	-7.29	high_impact	4.1	0.76	neutral	0.15	damaging	4.23	23.90	deleterious	0.04	0.35	0.9	disease	0.87	disease	0.55	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.43	medium_impact	2.93	high_impact	0.15	0.8	46.62	8.86	0.53	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11916	11916	T	C	MI.18754	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1157	386	F	S	tTc/tCc	4.63	1	0	probably_damaging	1	neutral	0.07	neutral	2.02	neutral	-1.81	deleterious	-7.29	high_impact	4.1	0.75	neutral	0.19	damaging	4.34	24.10	deleterious	0.03	0.35	0.77	disease	0.85	disease	0.68	disease	0.73	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-3.54	low_impact	-0.43	medium_impact	2.93	high_impact	0.11	0.8	46.62	8.86	0.61	P	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11917	11917	C	G	MI.18755	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1158	386	F	L	ttC/ttG	5.55	1	0	probably_damaging	1	neutral	0.47	neutral	2.16	neutral	2.77	deleterious	-5.45	medium_impact	2.28	0.77	neutral	0.21	damaging	4.44	24.20	deleterious	0.21	0.45	0.59	disease	0.72	disease	0.36	neutral	0.53	disease	1	0.99	deleterious	0.24	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	0.17	medium_impact	1.13	medium_impact	0.60	0.8	46.62	8.86	0.51	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11917	11917	C	A	MI.18756	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1158	386	F	L	ttC/ttA	5.55	1	0	probably_damaging	1	neutral	0.47	neutral	2.16	neutral	2.77	deleterious	-5.45	medium_impact	2.28	0.77	neutral	0.21	damaging	4.69	24.60	deleterious	0.21	0.45	0.59	disease	0.72	disease	0.36	neutral	0.53	disease	1	0.99	deleterious	0.24	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	0.17	medium_impact	1.13	medium_impact	0.60	0.8	46.62	8.86	0.51	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11918	11918	T	G	MI.18757	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1159	387	S	A	Tcc/Gcc	-0.43	0.24	0	probably_damaging	0.99	neutral	0.11	neutral	2.25	neutral	-1.43	deleterious	-2.67	medium_impact	2.87	0.73	neutral	0.19	damaging	3.63	23.20	deleterious	0.31	0.45	0.66	disease	0.42	neutral	0.58	disease	0.66	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.67	deleterious	-2.59	low_impact	-0.31	medium_impact	1.71	medium_impact	0.17	0.8	43.14	8.74	0.35	N	0.51	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11918	11918	T	A	MI.18758	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1159	387	S	T	Tcc/Acc	-0.43	0.24	0	probably_damaging	1	neutral	0.11	neutral	2.19	neutral	0.15	neutral	-1.99	medium_impact	2.61	0.79	neutral	0.5	neutral	3.76	23.30	deleterious	0.34	0.5	0.59	disease	0.39	neutral	0.57	disease	0.65	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.68	deleterious	-3.54	low_impact	-0.31	medium_impact	1.46	medium_impact	0.36	0.8	43.14	8.74	0.33	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11918	11918	T	C	MI.18759	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1159	387	S	P	Tcc/Ccc	-0.43	0.24	0	probably_damaging	1	neutral	0.05	neutral	2.15	deleterious	-4.12	deleterious	-3.94	medium_impact	3.07	0.59	damaging	0.1	damaging	4.05	23.70	deleterious	0.1	0.4	0.88	disease	0.87	disease	0.72	disease	0.81	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.84	deleterious	-3.54	low_impact	-0.52	medium_impact	1.91	medium_impact	0.15	0.8	43.14	8.74	0.31	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5904	5904	A	T	MI.1876	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1	1	M	L	Atg/Ttg	-1.96	0	0	possibly_damaging	0.7	neutral	0.06	neutral	3.13	neutral	1.41	neutral	-0.1	NA	NA	0.62	neutral	0.12	damaging	1.94	15.84	deleterious	0.4	0.55	0.24	neutral	0.13	neutral	0.22	neutral	0.15	neutral	7	0.95	neutral	0.18	neutral	-1	neutral	0.49	deleterious	NA	NA	NA	NA	NA	NA	0.57	0.9	3.12	6.73	0.48	N	0.60	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11919	11919	C	A	MI.18760	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1160	387	S	Y	tCc/tAc	2.56	0.72	0	probably_damaging	1	neutral	0.06	neutral	2.13	deleterious	-3.37	deleterious	-4.55	medium_impact	2.61	0.74	neutral	0.14	damaging	4.19	23.80	deleterious	0.13	0.4	0.67	disease	0.73	disease	0.65	disease	0.67	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	-0.47	medium_impact	1.46	medium_impact	0.20	0.8	43.14	8.74	0.35	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11919	11919	C	T	MI.18761	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1160	387	S	F	tCc/tTc	2.56	0.72	0	probably_damaging	1	neutral	0.14	neutral	2.12	neutral	-2.9	deleterious	-4.84	medium_impact	3.42	0.65	neutral	0.1	damaging	4.42	24.20	deleterious	0.15	0.45	0.56	disease	0.78	disease	0.64	disease	0.69	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.24	medium_impact	2.26	high_impact	0.05	0.8	43.14	8.74	0.4	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	C11919T	Thyroid Cancer Cell Line	+	-	Reported	1	.	P	P	neutral
chrM	11919	11919	C	G	MI.18762	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1160	387	S	C	tCc/tGc	2.56	0.72	0	probably_damaging	1	deleterious	0.01	neutral	2.11	deleterious	-4.12	deleterious	-4.22	medium_impact	3.42	0.64	neutral	0.09	damaging	3.73	23.30	deleterious	0.12	0.4	0.87	disease	0.74	disease	0.48	neutral	0.66	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-3.54	low_impact	-0.92	medium_impact	2.26	high_impact	0.24	0.8	43.14	8.74	0.37	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11921	11921	T	G	MI.18763	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1162	388	W	G	Tga/Gga	-2.5	0	0	probably_damaging	1	deleterious	0.01	neutral	2.26	neutral	0.07	deleterious	-12.1	high_impact	4.21	0.54	damaging	0.08	damaging	3.99	23.60	deleterious	0.07	0.35	0.9	disease	0.83	disease	0.82	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-0.92	medium_impact	3.04	high_impact	0.17	0.8	46.84	9.32	0.45	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11921	11921	T	C	MI.18764	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1162	388	W	R	Tga/Cga	-2.5	0	0	probably_damaging	1	deleterious	0.01	neutral	2.26	neutral	-2.58	deleterious	-13.03	high_impact	4.21	0.55	damaging	0.07	damaging	3.65	23.20	deleterious	0.08	0.35	0.88	disease	0.89	disease	0.86	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-0.92	medium_impact	3.04	high_impact	0.11	0.8	46.84	9.32	0.48	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11922	11922	G	T	MI.18765	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1163	388	W	L	tGa/tTa	7.4	1	0	probably_damaging	1	neutral	0.09	neutral	2.28	neutral	0.39	deleterious	-12.1	high_impact	3.66	0.54	damaging	0.05	damaging	4.40	24.10	deleterious	0.11	0.4	0.31	neutral	0.83	disease	0.8	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.72	deleterious	-3.54	low_impact	-0.36	medium_impact	2.5	high_impact	0.20	0.8	46.84	9.32	0.6	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11922	11922	G	C	MI.18766	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1163	388	W	S	tGa/tCa	7.4	1	0	probably_damaging	1	neutral	0.07	neutral	2.31	neutral	-0.14	deleterious	-13.03	high_impact	3.66	0.53	damaging	0.08	damaging	4.20	23.90	deleterious	0.11	0.4	0.83	disease	0.89	disease	0.81	disease	0.77	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.43	medium_impact	2.5	high_impact	0.19	0.8	46.84	9.32	0.61	P	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11923	11923	A	T	MI.18767	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1164	388	W	C	tgA/tgT	6.01	1	0	probably_damaging	1	deleterious	0	neutral	2.2	deleterious	-5.12	deleterious	-12.1	high_impact	4.21	0.52	damaging	0.05	damaging	4.24	23.90	deleterious	0.08	0.35	0.92	disease	0.89	disease	0.83	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.04	high_impact	0.11	0.8	46.84	9.32	0.61	P	0.98	polymorphism	1	0.10	rs386829142	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11923	11923	A	C	MI.18768	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1164	388	W	C	tgA/tgC	6.01	1	0	probably_damaging	1	deleterious	0	neutral	2.2	deleterious	-5.12	deleterious	-12.1	high_impact	4.21	0.52	damaging	0.05	damaging	4.16	23.80	deleterious	0.08	0.35	0.92	disease	0.89	disease	0.83	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.04	high_impact	0.11	0.8	46.84	9.32	0.6	P	0.98	polymorphism	1	0.10	rs386829142	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11924	11924	T	A	MI.18769	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1165	389	S	T	Tca/Aca	2.1	1	0	benign	0.31	deleterious	0.03	neutral	2.14	neutral	-0.46	deleterious	-2.7	medium_impact	2.53	0.74	neutral	0.58	neutral	2.01	16.24	deleterious	0.3	0.45	0.85	disease	0.58	disease	0.47	neutral	0.56	disease	1	0.97	neutral	0.36	neutral	1	deleterious	0.35	neutral	-0.39	medium_impact	-0.64	medium_impact	1.38	medium_impact	0.55	0.8	37.04	8.06	0.52	P	0.72	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5904	5904	A	C	MI.1877	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1	1	M	L	Atg/Ctg	-1.96	0	0	possibly_damaging	0.7	neutral	0.06	neutral	3.13	neutral	1.41	neutral	-0.1	NA	NA	0.62	neutral	0.12	damaging	1.93	15.75	deleterious	0.4	0.55	0.24	neutral	0.13	neutral	0.22	neutral	0.15	neutral	7	0.95	neutral	0.18	neutral	-1	neutral	0.49	deleterious	NA	NA	NA	NA	NA	NA	0.57	0.9	3.12	6.73	0.48	N	0.60	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11924	11924	T	C	MI.18770	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1165	389	S	P	Tca/Cca	2.1	1	0	possibly_damaging	0.77	deleterious	0.01	neutral	2.07	deleterious	-4.11	deleterious	-4.53	high_impact	3.98	0.68	neutral	0.53	neutral	2.21	17.54	deleterious	0.06	0.35	0.97	disease	0.83	disease	0.76	disease	0.85	disease	7	0.99	deleterious	0.12	neutral	5	deleterious	0.54	deleterious	-1.21	low_impact	-0.92	medium_impact	2.81	high_impact	0.17	0.8	37.04	8.06	0.58	P	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11924	11924	T	G	MI.18771	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1165	389	S	A	Tca/Gca	2.1	1	0	benign	0.01	neutral	0.05	neutral	2.17	neutral	-1.42	deleterious	-2.59	low_impact	1.7	0.73	neutral	0.67	neutral	1.86	15.36	deleterious	0.3	0.45	0.44	neutral	0.53	disease	0.48	neutral	0.44	neutral	1	0.95	neutral	0.52	deleterious	-6	neutral	0.20	neutral	1.16	medium_impact	-0.52	medium_impact	0.56	medium_impact	0.31	0.8	37.04	8.06	0.55	P	0.51	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11925	11925	C	G	MI.18772	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1166	389	S	W	tCa/tGa	7.4	1	0	probably_damaging	0.91	deleterious	0.01	neutral	2.05	deleterious	-5.54	deleterious	-6.31	high_impact	3.63	0.7	neutral	0.49	neutral	2.81	21.40	deleterious	0.07	0.35	1	disease	0.88	disease	0.73	disease	0.86	disease	7	1	deleterious	0.05	neutral	6	deleterious	0.73	deleterious	-1.66	low_impact	-0.92	medium_impact	2.47	high_impact	0.11	0.8	37.04	8.06	0.55	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11925	11925	C	T	MI.18773	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1166	389	S	L	tCa/tTa	7.4	1	0	possibly_damaging	0.44	deleterious	0.04	neutral	2.12	neutral	0.79	deleterious	-5.39	high_impact	3.63	0.71	neutral	0.5	neutral	2.78	21.20	deleterious	0.09	0.4	0.94	disease	0.85	disease	0.65	disease	0.82	disease	6	0.95	neutral	0.3	neutral	5	deleterious	0.35	neutral	-0.62	medium_impact	-0.57	medium_impact	2.47	high_impact	0.35	0.8	37.04	8.06	0.64	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11927	11927	A	T	MI.18774	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1168	390	N	Y	Aat/Tat	-11.71	0	0	benign	0	neutral	1	neutral	2.17	neutral	-0.54	deleterious	-5.27	low_impact	1.84	0.75	neutral	0.63	neutral	1.97	16.00	deleterious	0.15	0.45	0.8	disease	0.54	disease	0.15	neutral	0.58	disease	1	0	neutral	1	deleterious	-6	neutral	0.74	deleterious	2.1	high_impact	1.88	high_impact	0.69	medium_impact	0.24	0.8	21.13	24.27	0.3	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11927	11927	A	C	MI.18775	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1168	390	N	H	Aat/Cat	-11.71	0	0	benign	0	neutral	0.54	neutral	2.2	neutral	3	deleterious	-3.12	low_impact	1.04	0.75	neutral	0.76	neutral	1.67	14.26	neutral	0.38	0.5	0.52	disease	0.51	disease	0.23	neutral	0.45	neutral	1	0.46	neutral	0.77	deleterious	-6	neutral	0.69	deleterious	2.1	high_impact	0.24	medium_impact	-0.1	medium_impact	0.26	0.8	21.13	24.27	0.35	N	0.37	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11927	11927	A	G	MI.18776	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1168	390	N	D	Aat/Gat	-11.71	0	0	benign	0.12	neutral	0.21	neutral	2.2	neutral	3.67	deleterious	-3.38	medium_impact	2.19	0.78	neutral	0.5	neutral	2.67	20.60	deleterious	0.54	0.6	0.62	disease	0.48	neutral	0.39	neutral	0.59	disease	2	0.76	neutral	0.55	deleterious	-3	neutral	0.70	deleterious	0.1	medium_impact	-0.12	medium_impact	1.04	medium_impact	0.32	0.8	21.13	24.27	0.38	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11928	11928	A	T	MI.18777	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1169	390	N	I	aAt/aTt	-0.66	0	0	benign	0.27	neutral	0.39	neutral	2.16	neutral	2.32	deleterious	-6.42	medium_impact	2.4	0.78	neutral	0.5	neutral	2.57	19.90	deleterious	0.17	0.45	0.45	neutral	0.63	disease	0.29	neutral	0.5	disease	0	0.53	neutral	0.56	deleterious	-3	neutral	0.69	deleterious	-0.31	medium_impact	0.09	medium_impact	1.25	medium_impact	0.18	0.8	21.13	24.27	0.36	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11928	11928	A	G	MI.18778	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1169	390	N	S	aAt/aGt	-0.66	0	0	benign	0.08	neutral	0.4	neutral	2.26	neutral	0.72	deleterious	-3.16	low_impact	1.5	0.69	neutral	0.89	neutral	1.61	13.93	neutral	0.43	0.55	0.56	disease	0.34	neutral	0.31	neutral	0.6	disease	2	0.55	neutral	0.66	deleterious	-6	neutral	0.66	deleterious	0.28	medium_impact	0.1	medium_impact	0.36	medium_impact	0.21	0.8	21.13	24.27	0.38	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	COSM1138240	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11928	11928	A	C	MI.18779	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1169	390	N	T	aAt/aCt	-0.66	0	0	benign	0.15	neutral	0.39	neutral	2.22	neutral	1.48	deleterious	-3.99	low_impact	1.17	0.76	neutral	0.69	neutral	2.03	16.41	deleterious	0.35	0.5	0.42	neutral	0.33	neutral	0.15	neutral	0.47	neutral	1	0.54	neutral	0.62	deleterious	-6	neutral	0.65	deleterious	-0.01	medium_impact	0.09	medium_impact	0.03	medium_impact	0.26	0.8	21.13	24.27	0.46	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5904	5904	A	G	MI.1878	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1	1	M	V	Atg/Gtg	-1.96	0	0	possibly_damaging	0.79	deleterious	0	neutral	3.07	neutral	1.02	neutral	-0.13	NA	NA	0.59	damaging	0.13	damaging	2.43	19.00	deleterious	0.62	0.65	0.25	neutral	0.18	neutral	0.2	neutral	0.23	neutral	5	1	deleterious	0.11	neutral	3	deleterious	0.54	deleterious	NA	NA	NA	NA	NA	NA	0.37	0.9	3.12	6.73	0.46	N	0.87	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11929	11929	T	A	MI.18780	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1170	390	N	K	aaT/aaA	0.49	0	0.01	benign	0	neutral	0.3	neutral	2.23	neutral	1.76	deleterious	-3.66	low_impact	1.36	0.8	neutral	0.57	neutral	3.17	22.60	deleterious	0.37	0.5	0.5	neutral	0.52	disease	0.42	neutral	0.47	neutral	1	0.7	neutral	0.65	deleterious	-6	neutral	0.72	deleterious	2.1	high_impact	0	medium_impact	0.22	medium_impact	0.29	0.8	21.13	24.27	0.35	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11929	11929	T	G	MI.18781	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1170	390	N	K	aaT/aaG	0.49	0	0.01	benign	0	neutral	0.3	neutral	2.23	neutral	1.76	deleterious	-3.66	low_impact	1.36	0.8	neutral	0.57	neutral	2.84	21.60	deleterious	0.37	0.5	0.5	neutral	0.52	disease	0.42	neutral	0.47	neutral	1	0.7	neutral	0.65	deleterious	-6	neutral	0.72	deleterious	2.1	high_impact	0	medium_impact	0.22	medium_impact	0.29	0.8	21.13	24.27	0.33	N	0.94	polymorphism	1	0.06	rs28722520	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11930	11930	A	C	MI.18782	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1171	391	I	L	Atc/Ctc	-5.04	0	0	benign	0	neutral	0.99	neutral	2.32	neutral	3.78	neutral	0.26	low_impact	0.86	0.71	neutral	0.94	neutral	0.30	5.73	deleterious	0.25	0.45	0.46	neutral	0.24	neutral	0.19	neutral	0.45	neutral	1	0	neutral	1	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	1.32	medium_impact	-0.28	medium_impact	0.49	0.8	24.4	18.82	0.42	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11930	11930	A	G	MI.18783	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1171	391	I	V	Atc/Gtc	-5.04	0	0	benign	0	neutral	0.61	neutral	2.27	neutral	1.42	neutral	-0.44	low_impact	1.26	0.78	neutral	0.77	neutral	0.01	2.65	deleterious	0.35	0.5	0.41	neutral	0.16	neutral	0.42	neutral	0.31	neutral	4	0.39	neutral	0.81	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.31	medium_impact	0.12	medium_impact	0.36	0.8	24.4	18.82	0.33	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11930	11930	A	T	MI.18784	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1171	391	I	F	Atc/Ttc	-5.04	0	0	benign	0	neutral	1	neutral	2.16	neutral	-0.28	neutral	1.28	neutral_impact	0.63	0.71	neutral	0.96	neutral	0.13	3.93	deleterious	0.18	0.45	0.66	disease	0.39	neutral	0.24	neutral	0.62	disease	2	0	neutral	1	deleterious	-6	neutral	0.21	neutral	2.1	high_impact	1.88	high_impact	-0.5	medium_impact	0.54	0.8	24.4	18.82	0.29	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11931	11931	T	C	MI.18785	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1172	391	I	T	aTc/aCc	-1.12	0	0	benign	0	neutral	0.49	neutral	2.15	neutral	1.75	neutral	-1.3	neutral_impact	0.25	0.76	neutral	0.98	neutral	0.36	6.21	deleterious	0.11	0.4	0.55	disease	0.26	neutral	0.29	neutral	0.52	disease	0	0.51	neutral	0.75	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.19	medium_impact	-0.88	medium_impact	0.23	0.8	24.4	18.82	0.41	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11931	11931	T	G	MI.18786	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1172	391	I	S	aTc/aGc	-1.12	0	0	benign	0.02	neutral	0.34	neutral	2.12	neutral	1.42	neutral	-1.93	low_impact	1.57	0.79	neutral	0.69	neutral	2.36	18.58	deleterious	0.04	0.35	0.62	disease	0.58	disease	0.45	neutral	0.5	neutral	0	0.65	neutral	0.66	deleterious	-6	neutral	0.20	neutral	0.87	medium_impact	0.04	medium_impact	0.43	medium_impact	0.20	0.8	24.4	18.82	0.3	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11931	11931	T	A	MI.18787	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1172	391	I	N	aTc/aAc	-1.12	0	0	benign	0.07	neutral	0.23	neutral	2.08	neutral	-2.16	deleterious	-2.87	medium_impact	2.54	0.7	neutral	0.5	neutral	2.48	19.36	deleterious	0.09	0.35	0.89	disease	0.65	disease	0.45	neutral	0.64	disease	3	0.75	neutral	0.58	deleterious	-3	neutral	0.27	neutral	0.34	medium_impact	-0.09	medium_impact	1.39	medium_impact	0.20	0.8	24.4	18.82	0.35	N	0.41	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11932	11932	C	G	MI.18788	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1173	391	I	M	atC/atG	0.49	0	0	benign	0.01	neutral	0.36	neutral	2.12	neutral	2.55	neutral	0.24	low_impact	1.14	0.77	neutral	0.93	neutral	0.30	5.68	deleterious	0.25	0.45	0.77	disease	0.27	neutral	0.27	neutral	0.59	disease	2	0.63	neutral	0.68	deleterious	-6	neutral	0.25	neutral	1.16	medium_impact	0.06	medium_impact	0	medium_impact	0.49	0.8	24.4	18.82	0.44	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11932	11932	C	A	MI.18789	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1173	391	I	M	atC/atA	0.49	0	0	benign	0.01	neutral	0.36	neutral	2.12	neutral	2.55	neutral	0.24	low_impact	1.14	0.77	neutral	0.93	neutral	0.75	9.12	deleterious	0.25	0.45	0.77	disease	0.27	neutral	0.27	neutral	0.59	disease	2	0.63	neutral	0.68	deleterious	-6	neutral	0.25	neutral	1.16	medium_impact	0.06	medium_impact	0	medium_impact	0.49	0.8	24.4	18.82	0.44	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5905	5905	T	A	MI.1879	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	2	1	M	K	aTg/aAg	3.83	1	0	possibly_damaging	0.9	deleterious	0	neutral	2.99	neutral	0.1	neutral	-0.2	NA	NA	0.62	neutral	0.11	damaging	3.76	23.30	deleterious	0.21	0.55	0.14	neutral	0.39	neutral	0.55	disease	0.37	neutral	3	1	deleterious	0.05	neutral	3	deleterious	0.68	deleterious	NA	NA	NA	NA	NA	NA	0.49	0.9	3.12	6.73	0.55	P	0.93	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11933	11933	A	T	MI.18790	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1174	392	T	S	Act/Tct	-8.03	0	0	benign	0.16	neutral	0.62	neutral	2.25	neutral	-0.13	deleterious	-2.5	medium_impact	2.27	0.75	neutral	0.89	neutral	2.04	16.48	deleterious	0.41	0.5	0.44	neutral	0.41	neutral	0.36	neutral	0.41	neutral	2	0.27	neutral	0.73	deleterious	-3	neutral	0.69	deleterious	-0.04	medium_impact	0.32	medium_impact	1.12	medium_impact	0.72	0.85	20.04	18.33	0.36	N	0.25	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11933	11933	A	G	MI.18791	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1174	392	T	A	Act/Gct	-8.03	0	0	possibly_damaging	0.58	neutral	0.2	neutral	2.38	neutral	2.03	deleterious	-3.77	medium_impact	3.04	0.68	neutral	0.28	damaging	3.52	23.10	deleterious	0.26	0.45	0.51	disease	0.63	disease	0.42	neutral	0.46	neutral	1	0.8	neutral	0.31	neutral	0	NA	0.71	deleterious	-0.85	medium_impact	-0.14	medium_impact	1.88	medium_impact	0.43	0.8	20.04	18.33	0.39	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11933	11933	A	C	MI.18792	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1174	392	T	P	Act/Cct	-8.03	0	0	probably_damaging	0.96	neutral	0.07	neutral	2.23	deleterious	-3.35	deleterious	-4.88	high_impact	4.14	0.66	neutral	0.14	damaging	3.56	23.10	deleterious	0.07	0.35	0.7	disease	0.86	disease	0.75	disease	0.79	disease	6	0.99	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-2.01	low_impact	-0.43	medium_impact	2.97	high_impact	0.35	0.8	20.04	18.33	0.4	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11934	11934	C	T	MI.18793	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1175	392	T	I	aCt/aTt	1.87	0.83	0	probably_damaging	0.96	neutral	0.26	neutral	2.29	neutral	1.82	deleterious	-5.05	high_impact	3.6	0.76	neutral	0.17	damaging	3.99	23.60	deleterious	0.15	0.45	0.55	disease	0.85	disease	0.61	disease	0.69	disease	4	0.97	neutral	0.15	neutral	2	deleterious	0.76	deleterious	-2.01	low_impact	-0.05	medium_impact	2.44	high_impact	0.77	0.85	20.04	18.33	0.37	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11934	11934	C	A	MI.18794	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1175	392	T	N	aCt/aAt	1.87	0.83	0	possibly_damaging	0.79	neutral	0.12	neutral	2.23	neutral	0.66	deleterious	-3.78	high_impact	3.6	0.73	neutral	0.16	damaging	3.66	23.20	deleterious	0.26	0.45	0.84	disease	0.8	disease	0.64	disease	0.71	disease	4	0.92	neutral	0.17	neutral	1	deleterious	0.78	deleterious	-1.26	low_impact	-0.28	medium_impact	2.44	high_impact	0.56	0.8	20.04	18.33	0.39	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11934	11934	C	G	MI.18795	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1175	392	T	S	aCt/aGt	1.87	0.83	0	benign	0.16	neutral	0.62	neutral	2.25	neutral	-0.13	deleterious	-2.5	medium_impact	2.27	0.75	neutral	0.89	neutral	2.24	17.80	deleterious	0.41	0.5	0.44	neutral	0.41	neutral	0.36	neutral	0.41	neutral	2	0.27	neutral	0.73	deleterious	-3	neutral	0.69	deleterious	-0.04	medium_impact	0.32	medium_impact	1.12	medium_impact	0.72	0.85	20.04	18.33	0.34	N	0.25	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11936	11936	C	T	MI.18796	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1177	393	L	F	Ctc/Ttc	-7.8	0	0	benign	0	neutral	0.47	neutral	2.04	neutral	-0.6	neutral	-2.23	neutral_impact	0.6	0.77	neutral	0.82	neutral	2.14	17.14	deleterious	0.25	0.45	0.8	disease	0.57	disease	0.29	neutral	0.6	disease	2	0.53	neutral	0.74	deleterious	-6	neutral	0.32	neutral	2.1	high_impact	0.17	medium_impact	-0.53	medium_impact	0.63	0.8	14.81	10.65	0.27	N	0.16	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11936	11936	C	G	MI.18797	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1177	393	L	V	Ctc/Gtc	-7.8	0	0	benign	0.01	neutral	0.2	neutral	2.07	neutral	0.04	neutral	-0.04	low_impact	0.82	0.82	neutral	0.88	neutral	1.50	13.29	neutral	0.27	0.45	0.54	disease	0.42	neutral	0.25	neutral	0.57	disease	1	0.8	neutral	0.6	deleterious	-6	neutral	0.15	neutral	1.16	medium_impact	-0.14	medium_impact	-0.32	medium_impact	0.63	0.8	14.81	10.65	0.43	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11936	11936	C	A	MI.18798	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1177	393	L	I	Ctc/Atc	-7.8	0	0	benign	0	neutral	1	neutral	2.1	neutral	-0.3	neutral	0.76	neutral_impact	-2.04	0.72	neutral	0.95	neutral	-0.51	0.21	neutral	0.3	0.45	0.49	neutral	0.05	neutral	0.15	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	1.88	high_impact	-3.14	low_impact	0.54	0.8	14.81	10.65	0.37	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11937	11937	T	G	MI.18799	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1178	393	L	R	cTc/cGc	0.26	0.02	0	benign	0.33	deleterious	0.03	neutral	1.96	deleterious	-5.09	deleterious	-4.6	medium_impact	2.02	0.65	neutral	0.48	neutral	2.58	19.99	deleterious	0.02	0.35	0.84	disease	0.89	disease	0.69	disease	0.79	disease	6	0.97	neutral	0.35	neutral	1	deleterious	0.62	deleterious	-0.43	medium_impact	-0.64	medium_impact	0.87	medium_impact	0.26	0.8	14.81	10.65	0.28	N	0.60	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8615	8615	T	G	MI.188	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	89	30	L	W	tTg/tGg	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	4.22	neutral	-2.44	deleterious	-4.67	medium_impact	3.42	0.79	neutral	0.42	neutral	3.58	23.20	deleterious	0.16	0.65	0.92	disease	0.67	disease	0.28	neutral	0.69	disease	4	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	1.83	medium_impact	0.52	0.9	17.7	14.1	0.36	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5905	5905	T	C	MI.1880	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	2	1	M	T	aTg/aCg	3.83	1	0	possibly_damaging	0.9	deleterious	0	neutral	2.98	neutral	0	neutral	-0.15	NA	NA	0.62	neutral	0.09	damaging	2.71	20.90	deleterious	0.47	0.55	0.16	neutral	0.29	neutral	0.52	disease	0.35	neutral	3	1	deleterious	0.05	neutral	3	deleterious	0.68	deleterious	NA	NA	NA	NA	NA	NA	0.25	0.9	3.12	6.73	0.49	P	0.80	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11937	11937	T	C	MI.18800	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1178	393	L	P	cTc/cCc	0.26	0.02	0	possibly_damaging	0.5	deleterious	0.02	neutral	1.98	deleterious	-5.66	deleterious	-4.89	medium_impact	2.02	0.6	damaging	0.42	neutral	3.52	23.10	deleterious	0.02	0.35	0.7	disease	0.88	disease	0.69	disease	0.79	disease	6	0.98	neutral	0.26	neutral	4	deleterious	0.69	deleterious	-0.72	medium_impact	-0.75	medium_impact	0.87	medium_impact	0.35	0.8	14.81	10.65	0.28	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11937	11937	T	A	MI.18801	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1178	393	L	H	cTc/cAc	0.26	0.02	0	possibly_damaging	0.67	neutral	0.05	neutral	1.96	deleterious	-5.62	deleterious	-4.9	medium_impact	2.02	0.73	neutral	0.56	neutral	3.81	23.40	deleterious	0.04	0.35	0.89	disease	0.74	disease	0.64	disease	0.77	disease	5	0.95	neutral	0.19	neutral	0	NA	0.68	deleterious	-1.01	low_impact	-0.52	medium_impact	0.87	medium_impact	0.26	0.8	14.81	10.65	0.34	N	0.57	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11939	11939	C	G	MI.18802	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1180	394	L	V	Cta/Gta	-9.41	0	0	benign	0	neutral	0.43	neutral	2.23	neutral	0.94	neutral	-0.22	low_impact	1.05	0.77	neutral	0.97	neutral	0.19	4.62	deleterious	0.25	0.45	0.57	disease	0.31	neutral	0.24	neutral	0.6	disease	2	0.57	neutral	0.72	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.13	medium_impact	-0.09	medium_impact	0.57	0.8	23.53	23.06	0.42	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11939	11939	C	A	MI.18803	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1180	394	L	M	Cta/Ata	-9.41	0	0	benign	0.01	neutral	0.15	neutral	2.08	neutral	-0.09	neutral	-0.65	neutral_impact	-0.1	0.77	neutral	0.84	neutral	0.61	8.25	deleterious	0.24	0.45	0.63	disease	0.32	neutral	0.25	neutral	0.6	disease	2	0.85	neutral	0.57	deleterious	-6	neutral	0.15	neutral	1.16	medium_impact	-0.22	medium_impact	-1.23	low_impact	0.35	0.8	23.53	23.06	0.4	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11940	11940	T	A	MI.18804	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1181	394	L	Q	cTa/cAa	-1.81	0	0	benign	0.23	deleterious	0.02	neutral	2.03	deleterious	-3.61	deleterious	-4.07	medium_impact	2.62	0.73	neutral	0.55	neutral	2.28	18.02	deleterious	0.04	0.35	0.7	disease	0.71	disease	0.52	disease	0.6	disease	2	0.98	neutral	0.4	neutral	1	deleterious	0.37	neutral	-0.23	medium_impact	-0.75	medium_impact	1.47	medium_impact	0.29	0.8	23.53	23.06	0.34	N	0.86	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11940	11940	T	C	MI.18805	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1181	394	L	P	cTa/cCa	-1.81	0	0	benign	0.23	neutral	0.17	neutral	2.03	neutral	-0.42	deleterious	-4.42	low_impact	1.52	0.72	neutral	0.47	neutral	2.11	16.94	deleterious	0.03	0.35	0.81	disease	0.84	disease	0.49	neutral	0.67	disease	3	0.8	neutral	0.47	deleterious	-6	neutral	0.46	deleterious	-0.23	medium_impact	-0.18	medium_impact	0.38	medium_impact	0.37	0.8	23.53	23.06	0.31	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11940	11940	T	G	MI.18806	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1181	394	L	R	cTa/cGa	-1.81	0	0	benign	0.23	deleterious	0.03	neutral	2.04	deleterious	-3.43	deleterious	-4.2	medium_impact	2.62	0.7	neutral	0.48	neutral	2.41	18.86	deleterious	0.02	0.35	0.7	disease	0.85	disease	0.65	disease	0.77	disease	5	0.97	neutral	0.4	neutral	1	deleterious	0.39	neutral	-0.23	medium_impact	-0.64	medium_impact	1.47	medium_impact	0.29	0.8	23.53	23.06	0.31	N	0.89	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11942	11942	C	G	MI.18807	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1183	395	L	V	Ctt/Gtt	-8.49	0	0	benign	0.42	neutral	0.15	neutral	2.1	neutral	0.37	neutral	-2.17	medium_impact	2.58	0.78	neutral	0.62	neutral	3.47	23.00	deleterious	0.21	0.45	0.54	disease	0.49	neutral	0.39	neutral	0.49	neutral	0	0.83	neutral	0.37	neutral	-3	neutral	0.67	deleterious	-0.59	medium_impact	-0.22	medium_impact	1.43	medium_impact	0.48	0.8	18.95	15.46	0.35	N	0.86	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11942	11942	C	T	MI.18808	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1183	395	L	F	Ctt/Ttt	-8.49	0	0	benign	0.03	neutral	0.33	neutral	1.99	neutral	1.06	neutral	-2.39	low_impact	1.16	0.8	neutral	0.7	neutral	2.91	21.90	deleterious	0.18	0.45	0.8	disease	0.53	disease	0.26	neutral	0.58	disease	2	0.65	neutral	0.65	deleterious	-6	neutral	0.74	deleterious	0.7	medium_impact	0.03	medium_impact	0.02	medium_impact	0.38	0.8	18.95	15.46	0.29	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11942	11942	C	A	MI.18809	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1183	395	L	I	Ctt/Att	-8.49	0	0	benign	0.42	neutral	0.29	neutral	2.17	neutral	2.21	neutral	-1.35	low_impact	1.54	0.73	neutral	0.7	neutral	3.03	22.30	deleterious	0.24	0.45	0.6	disease	0.34	neutral	0.18	neutral	0.6	disease	2	0.67	neutral	0.44	neutral	-6	neutral	0.67	deleterious	-0.59	medium_impact	-0.02	medium_impact	0.4	medium_impact	0.41	0.8	18.95	15.46	0.47	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5906	5906	G	T	MI.1881	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	3	1	M	I	atG/atT	5.68	1	0	possibly_damaging	0.84	deleterious	0	neutral	3.06	neutral	0.85	neutral	-0.14	NA	NA	0.55	damaging	0.13	damaging	3.36	22.90	deleterious	0.48	0.55	0.27	neutral	0.24	neutral	0.35	neutral	0.31	neutral	4	1	deleterious	0.08	neutral	3	deleterious	0.63	deleterious	NA	NA	NA	NA	NA	NA	0.51	0.9	3.12	6.73	0.65	P	0.85	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11943	11943	T	C	MI.18810	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1184	395	L	P	cTt/cCt	-1.81	0	0	possibly_damaging	0.84	neutral	0.18	neutral	1.92	deleterious	-3.9	deleterious	-5.65	medium_impact	2.29	0.76	neutral	0.61	neutral	4.00	23.60	deleterious	0.02	0.35	0.93	disease	0.85	disease	0.52	disease	0.75	disease	5	0.91	neutral	0.17	neutral	0	NA	0.87	deleterious	-1.39	low_impact	-0.17	medium_impact	1.14	medium_impact	0.26	0.8	18.95	15.46	0.32	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11943	11943	T	A	MI.18811	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1184	395	L	H	cTt/cAt	-1.81	0	0	probably_damaging	0.94	deleterious	0.04	neutral	1.91	deleterious	-3.86	deleterious	-5.44	high_impact	3.67	0.7	neutral	0.41	neutral	4.28	24.00	deleterious	0.05	0.35	0.93	disease	0.81	disease	0.53	disease	0.78	disease	6	0.99	deleterious	0.05	neutral	6	deleterious	0.81	deleterious	-1.84	low_impact	-0.57	medium_impact	2.51	high_impact	0.27	0.8	18.95	15.46	0.38	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11943	11943	T	G	MI.18812	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1184	395	L	R	cTt/cGt	-1.81	0	0	possibly_damaging	0.84	deleterious	0.03	neutral	1.91	deleterious	-3.33	deleterious	-4.88	high_impact	3.67	0.63	neutral	0.35	neutral	4.26	23.90	deleterious	0.02	0.35	0.9	disease	0.88	disease	0.67	disease	0.8	disease	6	0.98	deleterious	0.1	neutral	5	deleterious	0.87	deleterious	-1.39	low_impact	-0.64	medium_impact	2.51	high_impact	0.18	0.8	18.95	15.46	0.36	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11945	11945	A	T	MI.18813	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1186	396	T	S	Aca/Tca	-20	0	0	possibly_damaging	0.47	neutral	0.13	neutral	2.21	neutral	0.85	neutral	-2.28	medium_impact	3.29	0.77	neutral	0.62	neutral	1.57	13.68	neutral	0.42	0.55	0.63	disease	0.65	disease	0.45	neutral	0.47	neutral	1	0.85	neutral	0.33	neutral	0	NA	0.39	neutral	-0.67	medium_impact	-0.26	medium_impact	2.13	high_impact	0.45	0.8	33.33	24.26	0.4	N	0.27	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11945	11945	A	G	MI.18814	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1186	396	T	A	Aca/Gca	-20	0	0	benign	0.22	neutral	0.18	neutral	2.47	neutral	0.31	deleterious	-2.61	medium_impact	2.56	0.8	neutral	0.82	neutral	1.65	14.14	neutral	0.25	0.45	0.4	neutral	0.59	disease	0.47	neutral	0.46	neutral	1	0.79	neutral	0.48	deleterious	-3	neutral	0.28	neutral	-0.2	medium_impact	-0.17	medium_impact	1.41	medium_impact	0.28	0.8	33.33	24.26	0.39	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11945	11945	A	C	MI.18815	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1186	396	T	P	Aca/Cca	-20	0	0	possibly_damaging	0.87	deleterious	0.04	neutral	2.15	neutral	0.86	deleterious	-3.73	medium_impact	3.5	0.67	neutral	0.58	neutral	3.24	22.80	deleterious	0.05	0.35	0.45	neutral	0.88	disease	0.69	disease	0.74	disease	5	0.98	deleterious	0.09	neutral	4	deleterious	0.64	deleterious	-1.49	low_impact	-0.57	medium_impact	2.34	high_impact	0.31	0.8	33.33	24.26	0.44	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11946	11946	C	T	MI.18816	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1187	396	T	M	aCa/aTa	1.87	0	0	benign	0.07	neutral	0.42	neutral	2.19	neutral	-0.94	neutral	-1.3	low_impact	1.53	0.82	neutral	0.93	neutral	1.04	10.89	neutral	0.13	0.4	0.58	disease	0.59	disease	0.3	neutral	0.49	neutral	0	0.53	neutral	0.68	deleterious	-6	neutral	0.49	deleterious	0.34	medium_impact	0.12	medium_impact	0.39	medium_impact	0.40	0.8	33.33	24.26	0.33	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11946	11946	C	A	MI.18817	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1187	396	T	K	aCa/aAa	1.87	0	0	possibly_damaging	0.6	deleterious	0.02	neutral	2.15	neutral	-0.36	deleterious	-3.33	high_impact	3.84	0.78	neutral	0.51	neutral	2.79	21.30	deleterious	0.1	0.4	0.79	disease	0.86	disease	0.68	disease	0.75	disease	5	0.98	deleterious	0.21	neutral	5	deleterious	0.56	deleterious	-0.88	medium_impact	-0.75	medium_impact	2.67	high_impact	0.40	0.8	33.33	24.26	0.42	N	0.70	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11948	11948	G	C	MI.18818	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1189	397	G	R	Gga/Cga	-3.42	0	0	probably_damaging	1	neutral	0.34	neutral	2.08	deleterious	-4.52	deleterious	-7.12	high_impact	4.11	0.72	neutral	0.1	damaging	4.03	23.70	deleterious	0.04	0.35	0.85	disease	0.92	disease	0.73	disease	0.82	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.54	low_impact	0.04	medium_impact	2.94	high_impact	0.43	0.8	44.23	9.18	0.34	N	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11948	11948	G	T	MI.18819	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1189	397	G	W	Gga/Tga	-3.42	0	0	probably_damaging	1	neutral	0.18	neutral	2.1	deleterious	-5.76	deleterious	-7.21	high_impact	4.11	0.67	neutral	0.11	damaging	4.50	24.30	deleterious	0.08	0.35	0.62	disease	0.93	disease	0.66	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.54	low_impact	-0.17	medium_impact	2.94	high_impact	0.16	0.8	44.23	9.18	0.33	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5906	5906	G	C	MI.1882	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	3	1	M	I	atG/atC	5.68	1	0	possibly_damaging	0.84	deleterious	0	neutral	3.06	neutral	0.85	neutral	-0.14	NA	NA	0.55	damaging	0.13	damaging	3.23	22.80	deleterious	0.48	0.55	0.27	neutral	0.24	neutral	0.35	neutral	0.31	neutral	4	1	deleterious	0.08	neutral	3	deleterious	0.63	deleterious	NA	NA	NA	NA	NA	NA	0.51	0.9	3.12	6.73	0.62	P	0.85	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11949	11949	G	C	MI.18820	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1190	397	G	A	gGa/gCa	9.01	1	0	probably_damaging	1	neutral	0.52	neutral	2.25	neutral	-0.96	deleterious	-5.16	medium_impact	2.17	0.79	neutral	0.59	neutral	3.15	22.60	deleterious	0.19	0.45	0.45	neutral	0.67	disease	0.34	neutral	0.47	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.22	medium_impact	1.02	medium_impact	0.36	0.8	44.23	9.18	0.51	N	0.45	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11949	11949	G	A	MI.18821	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1190	397	G	E	gGa/gAa	9.01	1	0	probably_damaging	1	neutral	0.27	neutral	2.07	deleterious	-4.82	deleterious	-7.11	high_impact	3.76	0.67	neutral	0.12	damaging	3.99	23.60	deleterious	0.05	0.35	0.88	disease	0.92	disease	0.72	disease	0.82	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.88	deleterious	-3.54	low_impact	-0.04	medium_impact	2.59	high_impact	0.20	0.8	44.23	9.18	0.62	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	COSM6716757	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11949	11949	G	T	MI.18822	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1190	397	G	V	gGa/gTa	9.01	1	0	probably_damaging	1	neutral	0.52	neutral	2.2	neutral	0.88	deleterious	-7.98	medium_impact	3.13	0.67	neutral	0.11	damaging	3.83	23.40	deleterious	0.09	0.4	0.47	neutral	0.87	disease	0.52	disease	0.63	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	0.22	medium_impact	1.97	medium_impact	0.16	0.8	44.23	9.18	0.49	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11951	11951	C	T	MI.18823	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1192	398	L	F	Ctc/Ttc	-2.04	0	0	benign	0.01	neutral	0.21	neutral	2.03	neutral	-1.89	neutral	-2.19	low_impact	1.82	0.81	neutral	0.94	neutral	1.16	11.56	neutral	0.27	0.45	0.43	neutral	0.45	neutral	0.35	neutral	0.47	neutral	1	0.79	neutral	0.6	deleterious	-6	neutral	0.33	neutral	1.16	medium_impact	-0.12	medium_impact	0.68	medium_impact	0.36	0.8	10.68	15.54	0.44	N	0.01	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11951	11951	C	G	MI.18824	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1192	398	L	V	Ctc/Gtc	-2.04	0	0	benign	0.12	neutral	0.25	neutral	2.15	neutral	-2.14	neutral	-1.36	medium_impact	2.4	0.76	neutral	0.94	neutral	0.32	5.87	deleterious	0.27	0.45	0.59	disease	0.32	neutral	0.3	neutral	0.6	disease	2	0.71	neutral	0.57	deleterious	-3	neutral	0.17	neutral	0.1	medium_impact	-0.07	medium_impact	1.25	medium_impact	0.45	0.8	10.68	15.54	0.46	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11951	11951	C	A	MI.18825	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1192	398	L	I	Ctc/Atc	-2.04	0	0	benign	0.12	neutral	0.31	neutral	2.2	neutral	0.14	neutral	-0.9	medium_impact	1.95	0.76	neutral	0.99	neutral	0.83	9.63	deleterious	0.27	0.45	0.4	neutral	0.3	neutral	0.26	neutral	0.47	neutral	1	0.64	neutral	0.6	deleterious	-3	neutral	0.17	neutral	0.1	medium_impact	0.01	medium_impact	0.8	medium_impact	0.40	0.8	10.68	15.54	0.52	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11952	11952	T	C	MI.18826	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1193	398	L	P	cTc/cCc	-7.8	0	0	possibly_damaging	0.5	deleterious	0.03	neutral	1.94	neutral	-0.33	deleterious	-4.58	medium_impact	2.85	0.62	neutral	0.58	neutral	2.14	17.09	deleterious	0.05	0.35	0.91	disease	0.81	disease	0.71	disease	0.76	disease	5	0.97	neutral	0.27	neutral	4	deleterious	0.46	deleterious	-0.72	medium_impact	-0.64	medium_impact	1.69	medium_impact	0.30	0.8	10.68	15.54	0.33	N	0.74	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11952	11952	T	A	MI.18827	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1193	398	L	H	cTc/cAc	-7.8	0	0	possibly_damaging	0.67	deleterious	0.02	neutral	1.94	deleterious	-4.86	deleterious	-4.58	high_impact	3.82	0.72	neutral	0.51	neutral	2.60	20.20	deleterious	0.07	0.35	0.91	disease	0.71	disease	0.68	disease	0.75	disease	5	0.98	deleterious	0.18	neutral	5	deleterious	0.57	deleterious	-1.01	low_impact	-0.75	medium_impact	2.65	high_impact	0.26	0.8	10.68	15.54	0.4	N	0.51	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11952	11952	T	G	MI.18828	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1193	398	L	R	cTc/cGc	-7.8	0	0	benign	0.43	deleterious	0.01	neutral	1.94	deleterious	-4.32	deleterious	-3.98	high_impact	3.82	0.69	neutral	0.45	neutral	2.39	18.78	deleterious	0.04	0.35	0.88	disease	0.81	disease	0.71	disease	0.78	disease	6	0.99	deleterious	0.29	neutral	2	deleterious	0.44	deleterious	-0.6	medium_impact	-0.92	medium_impact	2.65	high_impact	0.11	0.8	10.68	15.54	0.35	N	0.57	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11954	11954	A	C	MI.18829	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1195	399	N	H	Aac/Cac	-12.86	0	0	probably_damaging	1	neutral	0.53	neutral	2.29	deleterious	-3.03	deleterious	-3.76	medium_impact	3.17	0.8	neutral	0.12	damaging	3.17	22.70	deleterious	0.37	0.5	0.84	disease	0.59	disease	0.67	disease	0.72	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.77	deleterious	-3.54	low_impact	0.23	medium_impact	2.01	high_impact	0.20	0.8	47.28	9.45	0.22	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5907	5907	T	A	MI.1883	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	4	2	F	I	Ttc/Atc	7.3	1	0	benign	0	neutral	0.39	neutral	2.55	deleterious	-3.32	neutral	-0.12	low_impact	1.04	0.72	neutral	0.63	neutral	0.72	8.98	deleterious	0.35	0.55	0.15	neutral	0.31	neutral	0.44	neutral	0.38	neutral	2	0.6	neutral	0.7	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.09	medium_impact	-0.14	medium_impact	0.44	0.9	10.14	44.98	0.59	P	0.41	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11954	11954	A	T	MI.18830	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1195	399	N	Y	Aac/Tac	-12.86	0	0	probably_damaging	1	neutral	1	neutral	2.31	neutral	-2.94	deleterious	-5.96	medium_impact	2.82	0.74	neutral	0.11	damaging	3.73	23.30	deleterious	0.13	0.4	0.74	disease	0.66	disease	0.61	disease	0.71	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.77	deleterious	-3.54	low_impact	1.88	high_impact	1.66	medium_impact	0.26	0.8	47.28	9.45	0.16	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11954	11954	A	G	MI.18831	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1195	399	N	D	Aac/Gac	-12.86	0	0	probably_damaging	1	neutral	0.2	neutral	2.29	neutral	-2.4	deleterious	-3.47	medium_impact	3.17	0.71	neutral	0.12	damaging	3.86	23.50	deleterious	0.46	0.55	0.88	disease	0.61	disease	0.65	disease	0.74	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.14	medium_impact	2.01	high_impact	0.25	0.8	47.28	9.45	0.31	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11955	11955	A	T	MI.18832	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1196	399	N	I	aAc/aTc	3.25	0.99	0	probably_damaging	1	neutral	0.4	neutral	2.39	neutral	1.66	deleterious	-6.88	low_impact	1.88	0.71	neutral	0.14	damaging	4.08	23.70	deleterious	0.15	0.45	0.48	neutral	0.68	disease	0.58	disease	0.53	disease	1	1	deleterious	0.2	neutral	-2	neutral	0.72	deleterious	-3.54	low_impact	0.1	medium_impact	0.73	medium_impact	0.20	0.8	47.28	9.45	0.4	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11955	11955	A	G	MI.18833	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1196	399	N	S	aAc/aGc	3.25	0.99	0	probably_damaging	1	neutral	0.4	neutral	2.38	neutral	0.35	deleterious	-3.17	low_impact	1.31	0.75	neutral	0.34	neutral	3.13	22.60	deleterious	0.46	0.55	0.49	neutral	0.42	neutral	0.38	neutral	0.42	neutral	2	1	deleterious	0.2	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.1	medium_impact	0.17	medium_impact	0.27	0.8	47.28	9.45	0.48	N	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11955	11955	A	C	MI.18834	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1196	399	N	T	aAc/aCc	3.25	0.99	0	probably_damaging	1	neutral	0.39	neutral	2.46	neutral	-0.19	deleterious	-4.39	low_impact	1.03	0.74	neutral	0.3	neutral	3.45	23.00	deleterious	0.3	0.45	0.41	neutral	0.43	neutral	0.36	neutral	0.47	neutral	1	1	deleterious	0.2	neutral	-2	neutral	0.67	deleterious	-3.54	low_impact	0.09	medium_impact	-0.11	medium_impact	0.25	0.8	47.28	9.45	0.44	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11956	11956	C	G	MI.18835	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1197	399	N	K	aaC/aaG	3.48	0.99	0	probably_damaging	1	neutral	0.29	neutral	2.3	neutral	-0.23	deleterious	-4.39	medium_impact	2.82	0.7	neutral	0.11	damaging	4.01	23.60	deleterious	0.38	0.5	0.78	disease	0.7	disease	0.66	disease	0.71	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.02	medium_impact	1.66	medium_impact	0.32	0.8	47.28	9.45	0.49	N	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11956	11956	C	A	MI.18836	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1197	399	N	K	aaC/aaA	3.48	0.99	0	probably_damaging	1	neutral	0.29	neutral	2.3	neutral	-0.23	deleterious	-4.39	medium_impact	2.82	0.7	neutral	0.11	damaging	4.53	24.30	deleterious	0.38	0.5	0.78	disease	0.7	disease	0.66	disease	0.71	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.54	low_impact	-0.02	medium_impact	1.66	medium_impact	0.32	0.8	47.28	9.45	0.49	N	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11957	11957	A	T	MI.18837	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1198	400	M	L	Ata/Tta	-4.81	0	0	benign	0.02	neutral	0.44	neutral	2.47	neutral	2.47	neutral	-1.15	medium_impact	2	0.69	neutral	0.73	neutral	1.36	12.56	neutral	0.26	0.45	0.58	disease	0.63	disease	0.41	neutral	0.51	disease	0	0.54	neutral	0.71	deleterious	-3	neutral	0.18	neutral	0.87	medium_impact	0.14	medium_impact	0.85	medium_impact	0.27	0.8	21.13	19.97	0.39	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11957	11957	A	G	MI.18838	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1198	400	M	V	Ata/Gta	-4.81	0	0	benign	0	neutral	0.37	neutral	2.38	neutral	2.12	neutral	-0.88	low_impact	1.46	0.79	neutral	0.98	neutral	-0.56	0.15	neutral	0.25	0.45	0.43	neutral	0.46	neutral	0.4	neutral	0.46	neutral	1	0.63	neutral	0.69	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	0.07	medium_impact	0.32	medium_impact	0.26	0.8	21.13	19.97	0.39	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11957	11957	A	C	MI.18839	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1198	400	M	L	Ata/Cta	-4.81	0	0	benign	0.02	neutral	0.44	neutral	2.47	neutral	2.47	neutral	-1.15	medium_impact	2	0.69	neutral	0.73	neutral	1.28	12.17	neutral	0.26	0.45	0.58	disease	0.63	disease	0.41	neutral	0.51	disease	0	0.54	neutral	0.71	deleterious	-3	neutral	0.18	neutral	0.87	medium_impact	0.14	medium_impact	0.85	medium_impact	0.27	0.8	21.13	19.97	0.38	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5907	5907	T	C	MI.1884	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	4	2	F	L	Ttc/Ctc	7.3	1	0	benign	0	neutral	0.64	neutral	2.62	neutral	-2.25	neutral	-0.08	neutral_impact	0.49	0.77	neutral	0.74	neutral	-0.28	0.76	neutral	0.46	0.55	0.2	neutral	0.17	neutral	0.17	neutral	0.17	neutral	7	0.36	neutral	0.82	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.33	medium_impact	-0.65	medium_impact	0.42	0.9	10.14	44.98	0.52	N	0.01	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11958	11958	T	C	MI.18840	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1199	400	M	T	aTa/aCa	3.25	0.19	0	benign	0.01	neutral	1	neutral	2.4	neutral	2.84	neutral	-0.9	neutral_impact	0.62	0.66	neutral	0.94	neutral	-1.58	0.00	neutral	0.11	0.4	0.57	disease	0.09	neutral	0.34	neutral	0.29	neutral	4	0.01	neutral	1	deleterious	-6	neutral	0.17	neutral	1.16	medium_impact	1.88	high_impact	-0.51	medium_impact	0.18	0.8	21.13	19.97	0.39	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11958	11958	T	A	MI.18841	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1199	400	M	K	aTa/aAa	3.25	0.19	0	benign	0.16	neutral	0.11	neutral	2.23	neutral	-0.93	deleterious	-3.18	medium_impact	3.32	0.67	neutral	0.41	neutral	2.18	17.39	deleterious	0.06	0.35	0.84	disease	0.76	disease	0.7	disease	0.8	disease	6	0.87	neutral	0.48	deleterious	-3	neutral	0.38	neutral	-0.04	medium_impact	-0.31	medium_impact	2.16	high_impact	0.23	0.8	21.13	19.97	0.38	N	0.89	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11959	11959	A	C	MI.18842	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1200	400	M	I	atA/atC	1.41	0.16	0.01	benign	0.05	neutral	0.54	neutral	2.36	neutral	1.1	neutral	-1.19	low_impact	1.7	0.77	neutral	0.99	neutral	0.11	3.69	deleterious	0.26	0.45	0.4	neutral	0.43	neutral	0.38	neutral	0.46	neutral	1	0.41	neutral	0.75	deleterious	-6	neutral	0.16	neutral	0.48	medium_impact	0.24	medium_impact	0.56	medium_impact	0.23	0.8	21.13	19.97	0.35	N	0.11	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11959	11959	A	T	MI.18843	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1200	400	M	I	atA/atT	1.41	0.16	0.01	benign	0.05	neutral	0.54	neutral	2.36	neutral	1.1	neutral	-1.19	low_impact	1.7	0.77	neutral	0.99	neutral	0.17	4.37	deleterious	0.26	0.45	0.4	neutral	0.43	neutral	0.38	neutral	0.46	neutral	1	0.41	neutral	0.75	deleterious	-6	neutral	0.16	neutral	0.48	medium_impact	0.24	medium_impact	0.56	medium_impact	0.23	0.8	21.13	19.97	0.35	N	0.11	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11960	11960	C	G	MI.18844	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1201	401	L	V	Cta/Gta	-9.18	0	0	probably_damaging	1	neutral	0.37	neutral	2.27	neutral	0.93	neutral	-1.26	medium_impact	2.15	0.84	neutral	0.96	neutral	2.19	17.45	deleterious	0.33	0.5	0.56	disease	0.31	neutral	0.28	neutral	0.59	disease	2	1	deleterious	0.19	neutral	1	deleterious	0.68	deleterious	-3.54	low_impact	0.07	medium_impact	1	medium_impact	0.48	0.8	20.7	22.92	0.39	N	0.07	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11960	11960	C	A	MI.18845	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1201	401	L	M	Cta/Ata	-9.18	0	0	probably_damaging	1	neutral	0.09	neutral	2.08	neutral	-2.64	neutral	-1.13	medium_impact	2.6	0.82	neutral	0.79	neutral	2.68	20.70	deleterious	0.24	0.45	0.72	disease	0.45	neutral	0.32	neutral	0.63	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.71	deleterious	-3.54	low_impact	-0.36	medium_impact	1.45	medium_impact	0.49	0.8	20.7	22.92	0.44	N	0.45	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11961	11961	T	A	MI.18846	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1202	401	L	Q	cTa/cAa	-0.66	0	0	probably_damaging	1	deleterious	0	neutral	2.04	deleterious	-5.67	deleterious	-4.47	high_impact	3.98	0.72	neutral	0.53	neutral	4.43	24.20	deleterious	0.06	0.35	0.93	disease	0.73	disease	0.59	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	2.81	high_impact	0.26	0.8	20.7	22.92	0.41	N	0.86	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11961	11961	T	G	MI.18847	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1202	401	L	R	cTa/cGa	-0.66	0	0	probably_damaging	1	deleterious	0	neutral	2.05	deleterious	-5.49	deleterious	-4.67	high_impact	3.98	0.65	neutral	0.45	neutral	4.27	24.00	deleterious	0.04	0.35	0.92	disease	0.86	disease	0.72	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.81	high_impact	0.19	0.8	20.7	22.92	0.37	N	0.88	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11961	11961	T	C	MI.18848	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1202	401	L	P	cTa/cCa	-0.66	0	0	probably_damaging	1	deleterious	0	neutral	2.04	deleterious	-6.05	deleterious	-5.17	high_impact	3.98	0.65	neutral	0.43	neutral	4.02	23.60	deleterious	0.04	0.35	0.94	disease	0.83	disease	0.73	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.81	high_impact	0.23	0.8	20.7	22.92	0.34	N	0.94	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11963	11963	G	C	MI.18849	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1204	402	V	L	Gtc/Ctc	-0.66	0	0.02	benign	0.01	neutral	0.84	neutral	2.54	neutral	1.21	neutral	-0.66	neutral_impact	-1.38	0.68	neutral	0.95	neutral	0.53	7.69	deleterious	0.19	0.45	0.51	disease	0.33	neutral	0.24	neutral	0.34	neutral	3	0.13	neutral	0.92	deleterious	-6	neutral	0.14	neutral	1.16	medium_impact	0.61	medium_impact	-2.49	low_impact	0.19	0.8	34.2	8.3	0.32	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5907	5907	T	G	MI.1885	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	4	2	F	V	Ttc/Gtc	7.3	1	0	benign	0.02	neutral	0.5	neutral	2.55	deleterious	-3.28	neutral	-0.14	low_impact	1.04	0.78	neutral	0.62	neutral	0.21	4.74	deleterious	0.35	0.55	0.14	neutral	0.31	neutral	0.45	neutral	0.38	neutral	2	0.48	neutral	0.74	deleterious	-6	neutral	0.06	neutral	0.83	medium_impact	0.19	medium_impact	-0.14	medium_impact	0.33	0.9	10.14	44.98	0.55	P	0.56	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11963	11963	G	A	MI.18850	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1204	402	V	I	Gtc/Atc	-0.66	0	0.02	benign	0	neutral	1	neutral	2.32	neutral	1.01	neutral	0.74	neutral_impact	-2.9	0.68	neutral	0.95	neutral	-0.95	0.02	neutral	0.24	0.45	0.42	neutral	0.05	neutral	0.15	neutral	0.24	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	1.88	high_impact	-4	low_impact	0.44	0.8	34.2	8.3	0.33	N	0.02	polymorphism	1	0.01	rs201803948	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	11963	11963	G	T	MI.18851	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1204	402	V	F	Gtc/Ttc	-0.66	0	0.02	benign	0.13	neutral	1	neutral	2.28	neutral	0.1	deleterious	-2.63	neutral_impact	-0.9	0.71	neutral	0.73	neutral	2.00	16.23	deleterious	0.06	0.35	0.76	disease	0.58	disease	0.23	neutral	0.52	disease	0	0.13	neutral	0.94	deleterious	-6	neutral	0.23	neutral	0.06	medium_impact	1.88	high_impact	-2.02	low_impact	0.20	0.8	34.2	8.3	0.18	N	0.52	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11964	11964	T	G	MI.18852	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1205	402	V	G	gTc/gGc	0.72	0.09	0	benign	0.28	neutral	0.13	neutral	2.14	deleterious	-5.7	deleterious	-6.14	low_impact	1.04	0.72	neutral	0.48	neutral	2.02	16.33	deleterious	0.05	0.35	0.75	disease	0.59	disease	0.51	disease	0.55	disease	1	0.85	neutral	0.43	neutral	-6	neutral	0.28	neutral	-0.33	medium_impact	-0.26	medium_impact	-0.1	medium_impact	0.25	0.8	34.2	8.3	0.38	N	0.44	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11964	11964	T	C	MI.18853	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1205	402	V	A	gTc/gCc	0.72	0.09	0	benign	0.05	deleterious	0.02	neutral	2.22	neutral	0.86	deleterious	-3.42	neutral_impact	0.7	0.74	neutral	0.72	neutral	1.78	14.87	neutral	0.12	0.4	0.54	disease	0.37	neutral	0.48	neutral	0.58	disease	2	0.98	neutral	0.49	deleterious	-2	neutral	0.17	neutral	0.48	medium_impact	-0.75	medium_impact	-0.43	medium_impact	0.06	0.8	34.2	8.3	0.4	N	0.31	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11964	11964	T	A	MI.18854	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1205	402	V	D	gTc/gAc	0.72	0.09	0	possibly_damaging	0.47	deleterious	0	neutral	2.12	deleterious	-6.76	deleterious	-5.4	low_impact	1.04	0.69	neutral	0.47	neutral	2.83	21.50	deleterious	0.03	0.35	0.72	disease	0.79	disease	0.62	disease	0.76	disease	5	1	deleterious	0.27	neutral	1	deleterious	0.39	neutral	-0.67	medium_impact	-1.48	low_impact	-0.1	medium_impact	0.16	0.8	34.2	8.3	0.35	N	0.47	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11966	11966	A	T	MI.18855	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1207	403	T	S	Aca/Tca	-6.88	0	0	probably_damaging	1	neutral	1	neutral	1.94	neutral	0.81	deleterious	-3.71	medium_impact	2.44	0.7	neutral	0.2	damaging	3.33	22.90	deleterious	0.35	0.5	0.64	disease	0.45	neutral	0.46	neutral	0.56	disease	1	0.99	deleterious	0.5	deleterious	1	deleterious	0.72	deleterious	-3.54	low_impact	1.88	high_impact	1.29	medium_impact	0.60	0.8	45.53	9.79	0.21	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11966	11966	A	C	MI.18856	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1207	403	T	P	Aca/Cca	-6.88	0	0	probably_damaging	1	deleterious	0	neutral	1.79	deleterious	-4.49	deleterious	-5.56	high_impact	3.82	0.68	neutral	0.19	damaging	3.55	23.10	deleterious	0.05	0.35	0.53	disease	0.86	disease	0.75	disease	0.78	disease	6	1	deleterious	0	deleterious	6	deleterious	0.79	deleterious	-3.54	low_impact	-1.48	low_impact	2.65	high_impact	0.38	0.8	45.53	9.79	0.34	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11966	11966	A	G	MI.18857	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1207	403	T	A	Aca/Gca	-6.88	0	0	probably_damaging	1	neutral	0.16	neutral	1.93	neutral	0.3	deleterious	-4.63	medium_impact	2.75	0.71	neutral	0.2	damaging	3.53	23.10	deleterious	0.19	0.45	0.69	disease	0.61	disease	0.62	disease	0.54	disease	1	1	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.2	medium_impact	1.6	medium_impact	0.42	0.8	45.53	9.79	0.3	N	0.68	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11967	11967	C	T	MI.18858	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1208	403	T	M	aCa/aTa	6.7	1	0	probably_damaging	1	deleterious	0.02	neutral	1.8	deleterious	-4.6	deleterious	-5.56	high_impact	4.17	0.72	neutral	0.15	damaging	4.14	23.80	deleterious	0.09	0.35	0.5	disease	0.83	disease	0.71	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.72	deleterious	-3.54	low_impact	-0.75	medium_impact	3	high_impact	0.57	0.8	45.53	9.79	0.59	P	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11967	11967	C	A	MI.18859	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1208	403	T	K	aCa/aAa	6.7	1	0	probably_damaging	1	deleterious	0	neutral	1.82	neutral	-0.84	deleterious	-5.56	high_impact	4.17	0.71	neutral	0.13	damaging	4.56	24.40	deleterious	0.08	0.35	0.74	disease	0.89	disease	0.79	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3	high_impact	0.41	0.8	45.53	9.79	0.65	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5908	5908	T	C	MI.1886	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	5	2	F	S	tTc/tCc	1.28	0.99	0	benign	0.12	neutral	0.4	neutral	2.52	deleterious	-4.24	neutral	-0.17	neutral_impact	0.69	0.71	neutral	0.73	neutral	0.52	7.56	deleterious	0.32	0.55	0.3	neutral	0.31	neutral	0.25	neutral	0.38	neutral	2	0.54	neutral	0.64	deleterious	-6	neutral	0.16	neutral	0.06	medium_impact	0.1	medium_impact	-0.46	medium_impact	0.25	0.9	10.14	44.98	0.52	N	0.75	disease_causing	0.82	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11969	11969	G	C	MI.18860	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1210	404	A	P	Gcc/Ccc	-3.65	0	0.02	possibly_damaging	0.87	deleterious	0.01	neutral	1.73	deleterious	-6.84	deleterious	-4.26	high_impact	4.11	0.7	neutral	0.4	neutral	2.26	17.90	deleterious	0.03	0.35	0.88	disease	0.87	disease	0.79	disease	0.85	disease	7	1	deleterious	0.07	neutral	5	deleterious	0.65	deleterious	-1.49	low_impact	-0.92	medium_impact	2.94	high_impact	0.47	0.8	18.95	21.95	0.46	N	0.93	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11969	11969	G	A	MI.18861	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1210	404	A	T	Gcc/Acc	-3.65	0	0.02	benign	0.04	neutral	0.05	neutral	1.76	deleterious	-4.02	deleterious	-3.24	medium_impact	1.99	0.54	damaging	0.64	neutral	2.35	18.49	deleterious	0.1	0.4	0.69	disease	0.75	disease	0.49	neutral	0.51	disease	0	0.95	neutral	0.51	deleterious	-3	neutral	0.26	neutral	0.58	medium_impact	-0.52	medium_impact	0.84	medium_impact	0.63	0.8	18.95	21.95	0.42	N	0.16	polymorphism	1	0.12	rs28359169	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11969	11969	G	T	MI.18862	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1210	404	A	S	Gcc/Tcc	-3.65	0	0.02	possibly_damaging	0.48	neutral	0.12	neutral	1.85	deleterious	-3.25	neutral	-2.37	medium_impact	2.79	0.62	neutral	0.67	neutral	1.86	15.36	deleterious	0.19	0.45	0.4	neutral	0.79	disease	0.6	disease	0.62	disease	2	0.87	neutral	0.32	neutral	0	NA	0.27	neutral	-0.69	medium_impact	-0.28	medium_impact	1.63	medium_impact	0.44	0.8	18.95	21.95	0.39	N	0.59	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11970	11970	C	A	MI.18863	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1211	404	A	D	gCc/gAc	2.79	0.78	0	possibly_damaging	0.83	deleterious	0	neutral	1.71	deleterious	-4.11	deleterious	-5.03	high_impact	4.11	0.75	neutral	0.37	neutral	2.99	22.20	deleterious	0.03	0.35	0.89	disease	0.91	disease	0.77	disease	0.85	disease	7	1	deleterious	0.09	neutral	5	deleterious	0.56	deleterious	-1.37	low_impact	-1.48	low_impact	2.94	high_impact	0.28	0.8	18.95	21.95	0.51	P	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11970	11970	C	T	MI.18864	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1211	404	A	V	gCc/gTc	2.79	0.78	0	possibly_damaging	0.48	deleterious	0.02	neutral	1.8	deleterious	-3.11	deleterious	-3.3	medium_impact	3.42	0.65	neutral	0.54	neutral	2.59	20.20	deleterious	0.09	0.35	0.47	neutral	0.81	disease	0.6	disease	0.62	disease	2	0.98	neutral	0.27	neutral	4	deleterious	0.31	neutral	-0.69	medium_impact	-0.75	medium_impact	2.26	high_impact	0.69	0.85	18.95	21.95	0.43	N	0.49	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11970	11970	C	G	MI.18865	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1211	404	A	G	gCc/gGc	2.79	0.78	0	possibly_damaging	0.48	neutral	0.15	neutral	1.75	deleterious	-4.67	deleterious	-3.18	medium_impact	3.07	0.64	neutral	0.76	neutral	2.16	17.25	deleterious	0.18	0.45	0.55	disease	0.75	disease	0.67	disease	0.53	disease	1	0.83	neutral	0.34	neutral	0	NA	0.30	neutral	-0.69	medium_impact	-0.22	medium_impact	1.91	medium_impact	0.54	0.8	18.95	21.95	0.45	N	0.17	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11972	11972	C	G	MI.18866	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1213	405	L	V	Cta/Gta	-8.72	0	0	possibly_damaging	0.44	neutral	0.58	neutral	2.27	neutral	-2.22	neutral	-1.18	low_impact	1.49	0.75	neutral	0.26	damaging	2.03	16.41	deleterious	0.33	0.5	0.67	disease	0.25	neutral	0.23	neutral	0.54	disease	1	0.41	neutral	0.57	deleterious	-3	neutral	0.69	deleterious	-0.62	medium_impact	0.28	medium_impact	0.35	medium_impact	0.45	0.8	21.35	18.83	0.26	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11972	11972	C	A	MI.18867	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1213	405	L	M	Cta/Ata	-8.72	0	0	probably_damaging	0.94	neutral	0.24	neutral	2.13	deleterious	-5.05	neutral	-0.61	low_impact	1.59	0.8	neutral	0.9	neutral	2.63	20.40	deleterious	0.25	0.45	0.69	disease	0.22	neutral	0.23	neutral	0.47	neutral	1	0.96	neutral	0.15	neutral	-2	neutral	0.68	deleterious	-1.84	low_impact	-0.08	medium_impact	0.45	medium_impact	0.38	0.8	21.35	18.83	0.42	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11973	11973	T	C	MI.18868	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1214	405	L	P	cTa/cCa	-1.35	0	0	probably_damaging	0.98	neutral	0.2	neutral	2.08	deleterious	-6.56	deleterious	-3.59	medium_impact	3.12	0.72	neutral	0.11	damaging	2.68	20.70	deleterious	0.02	0.35	0.45	neutral	0.78	disease	0.57	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	-0.14	medium_impact	1.96	medium_impact	0.26	0.8	21.35	18.83	0.31	N	0.87	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11973	11973	T	A	MI.18869	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1214	405	L	Q	cTa/cAa	-1.35	0	0	probably_damaging	0.98	neutral	0.18	neutral	2.08	deleterious	-6.18	deleterious	-2.88	medium_impact	3.12	0.7	neutral	0.12	damaging	2.94	22.00	deleterious	0.04	0.35	0.85	disease	0.54	disease	0.4	neutral	0.6	disease	2	0.99	deleterious	0.1	neutral	1	deleterious	0.79	deleterious	-2.31	low_impact	-0.17	medium_impact	1.96	medium_impact	0.29	0.8	21.35	18.83	0.33	N	0.90	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5908	5908	T	G	MI.1887	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	5	2	F	C	tTc/tGc	1.28	0.99	0	benign	0.38	neutral	0.17	neutral	2.49	deleterious	-5.89	neutral	-0.21	low_impact	1.04	0.63	neutral	0.58	neutral	1.00	10.68	neutral	0.28	0.55	0.49	neutral	0.43	neutral	0.45	neutral	0.4	neutral	2	0.8	neutral	0.4	neutral	-6	neutral	0.44	deleterious	-0.56	medium_impact	-0.19	medium_impact	-0.14	medium_impact	0.20	0.9	10.14	44.98	0.53	P	0.61	disease_causing	0.87	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11973	11973	T	G	MI.18870	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1214	405	L	R	cTa/cGa	-1.35	0	0	probably_damaging	0.98	neutral	0.21	neutral	2.09	deleterious	-6	deleterious	-3.11	medium_impact	3.12	0.7	neutral	0.09	damaging	3.07	22.40	deleterious	0.03	0.35	0.88	disease	0.77	disease	0.54	disease	0.73	disease	5	0.99	deleterious	0.12	neutral	1	deleterious	0.86	deleterious	-2.31	low_impact	-0.12	medium_impact	1.96	medium_impact	0.28	0.8	21.35	18.83	0.27	N	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11975	11975	T	A	MI.18871	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1216	406	Y	N	Tac/Aac	-13.78	0	0	probably_damaging	1	deleterious	0	neutral	1.59	deleterious	-7.21	deleterious	-8.33	high_impact	4.23	0.58	damaging	0.14	damaging	4.06	23.70	deleterious	0.06	0.35	0.87	disease	0.87	disease	0.78	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.06	high_impact	0.19	0.8	47.28	9.59	0.41	N	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11975	11975	T	G	MI.18872	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1216	406	Y	D	Tac/Gac	-13.78	0	0	probably_damaging	1	deleterious	0	neutral	1.57	deleterious	-8.09	deleterious	-9.26	high_impact	4.23	0.67	neutral	0.13	damaging	3.98	23.60	deleterious	0.04	0.35	0.92	disease	0.89	disease	0.84	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.06	high_impact	0.15	0.8	47.28	9.59	0.42	N	0.99	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11975	11975	T	C	MI.18873	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1216	406	Y	H	Tac/Cac	-13.78	0	0	probably_damaging	1	deleterious	0	neutral	1.58	deleterious	-7.48	deleterious	-4.62	high_impact	4.23	0.58	damaging	0.13	damaging	3.61	23.20	deleterious	0.11	0.4	0.76	disease	0.84	disease	0.85	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-1.48	low_impact	3.06	high_impact	0.20	0.8	47.28	9.59	0.38	N	0.97	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11976	11976	A	G	MI.18874	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1217	406	Y	C	tAc/tGc	7.4	1	0	probably_damaging	1	deleterious	0	neutral	1.58	deleterious	-5.13	deleterious	-8.34	high_impact	4.23	0.6	damaging	0.11	damaging	3.48	23.10	deleterious	0.06	0.35	0.87	disease	0.9	disease	0.82	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.54	low_impact	-1.48	low_impact	3.06	high_impact	0.13	0.8	47.28	9.59	0.64	P	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11976	11976	A	T	MI.18875	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1217	406	Y	F	tAc/tTc	7.4	1	0	probably_damaging	1	neutral	0.09	neutral	1.67	neutral	-2.57	deleterious	-3.71	high_impact	3.54	0.6	neutral	0.17	damaging	3.33	22.90	deleterious	0.16	0.45	0.57	disease	0.82	disease	0.74	disease	0.73	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.36	medium_impact	2.38	high_impact	0.28	0.8	47.28	9.59	0.63	P	0.79	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11976	11976	A	C	MI.18876	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1217	406	Y	S	tAc/tCc	7.4	1	0	probably_damaging	1	deleterious	0.01	neutral	1.62	neutral	-2.95	deleterious	-8.33	high_impact	4.23	0.61	neutral	0.16	damaging	3.70	23.30	deleterious	0.06	0.35	0.75	disease	0.87	disease	0.77	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-0.92	medium_impact	3.06	high_impact	0.20	0.8	47.28	9.59	0.67	P	0.96	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11978	11978	T	A	MI.18877	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1219	407	S	T	Tcc/Acc	-1.12	0	0	probably_damaging	1	neutral	0.32	neutral	2.1	neutral	-2.9	neutral	-1.23	low_impact	1.68	0.75	neutral	0.97	neutral	2.74	21.00	deleterious	0.32	0.5	0.66	disease	0.21	neutral	0.44	neutral	0.47	neutral	1	1	deleterious	0.16	neutral	-2	neutral	0.69	deleterious	-3.54	low_impact	0.02	medium_impact	0.54	medium_impact	0.61	0.8	38.34	8.54	0.45	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11978	11978	T	C	MI.18878	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1219	407	S	P	Tcc/Ccc	-1.12	0	0	probably_damaging	1	deleterious	0.01	neutral	1.98	deleterious	-6.17	deleterious	-3.96	high_impact	4.07	0.56	damaging	0.4	neutral	4.11	23.70	deleterious	0.04	0.35	0.67	disease	0.89	disease	0.75	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-0.92	medium_impact	2.9	high_impact	0.37	0.8	38.34	8.54	0.41	N	0.93	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11978	11978	T	G	MI.18879	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1219	407	S	A	Tcc/Gcc	-1.12	0	0	probably_damaging	0.99	deleterious	0	neutral	2.11	neutral	-2.69	neutral	-2.33	high_impact	4.07	0.69	neutral	0.56	neutral	3.72	23.30	deleterious	0.26	0.45	0.48	neutral	0.63	disease	0.68	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.67	deleterious	-2.59	low_impact	-1.48	low_impact	2.9	high_impact	0.44	0.8	38.34	8.54	0.48	N	0.42	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5908	5908	T	A	MI.1888	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	5	2	F	Y	tTc/tAc	1.28	0.99	0	benign	0.02	neutral	1	neutral	2.69	neutral	-1.89	neutral	-0.02	low_impact	1.04	0.72	neutral	0.74	neutral	-0.59	0.13	neutral	0.35	0.55	0.31	neutral	0.1	neutral	0.13	neutral	0.15	neutral	7	0.02	neutral	0.99	deleterious	-6	neutral	0.09	neutral	0.83	medium_impact	1.86	high_impact	-0.14	medium_impact	0.34	0.9	10.14	44.98	0.41	N	0.38	polymorphism	0.64	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11979	11979	C	G	MI.18880	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1220	407	S	C	tCc/tGc	-0.2	0	0	probably_damaging	1	neutral	0.05	neutral	1.98	deleterious	-5.96	deleterious	-3.96	medium_impact	3.26	0.63	neutral	0.39	neutral	3.72	23.30	deleterious	0.06	0.35	0.92	disease	0.85	disease	0.67	disease	0.81	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.52	medium_impact	2.1	high_impact	0.31	0.8	38.34	8.54	0.32	N	0.49	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11979	11979	C	A	MI.18881	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1220	407	S	Y	tCc/tAc	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	2.05	neutral	0.17	deleterious	-4.87	high_impact	3.72	0.69	neutral	0.43	neutral	4.17	23.80	deleterious	0.05	0.35	0.83	disease	0.87	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.55	high_impact	0.32	0.8	38.34	8.54	0.35	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11979	11979	C	T	MI.18882	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1220	407	S	F	tCc/tTc	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	2.04	deleterious	-4.64	deleterious	-4.88	high_impact	4.07	0.61	neutral	0.43	neutral	4.37	24.10	deleterious	0.04	0.35	0.39	neutral	0.89	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	2.9	high_impact	0.23	0.8	38.34	8.54	0.4	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11981	11981	C	G	MI.18883	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1222	408	L	V	Ctc/Gtc	-4.58	0	0	benign	0.21	neutral	0.05	neutral	1.94	deleterious	-3.03	deleterious	-2.61	high_impact	4.18	0.56	damaging	0.54	neutral	3.52	23.10	deleterious	0.25	0.45	0.81	disease	0.6	disease	0.64	disease	0.69	disease	4	0.94	neutral	0.42	neutral	-2	neutral	0.78	deleterious	-0.18	medium_impact	-0.52	medium_impact	3.01	high_impact	0.59	0.8	19.39	22.54	0.43	N	0.48	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11981	11981	C	A	MI.18884	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1222	408	L	I	Ctc/Atc	-4.58	0	0	benign	0.05	neutral	0.28	neutral	1.95	deleterious	-4.44	neutral	-1.7	medium_impact	3.04	0.58	damaging	0.66	neutral	4.13	23.80	deleterious	0.3	0.45	0.63	disease	0.6	disease	0.53	disease	0.48	neutral	0	0.7	neutral	0.62	deleterious	-3	neutral	0.76	deleterious	0.48	medium_impact	-0.03	medium_impact	1.88	medium_impact	0.62	0.8	19.39	22.54	0.38	N	0.48	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11981	11981	C	T	MI.18885	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1222	408	L	F	Ctc/Ttc	-4.58	0	0	possibly_damaging	0.8	deleterious	0.03	neutral	1.98	neutral	-2.84	deleterious	-3.34	high_impact	3.84	0.54	damaging	0.62	neutral	4.04	23.70	deleterious	0.19	0.45	0.56	disease	0.72	disease	0.56	disease	0.58	disease	2	0.98	deleterious	0.12	neutral	5	deleterious	0.78	deleterious	-1.28	low_impact	-0.64	medium_impact	2.67	high_impact	0.54	0.8	19.39	22.54	0.44	N	0.72	polymorphism	1	0.11	rs386829143	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	11982	11982	T	A	MI.18886	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1223	408	L	H	cTc/cAc	-0.2	0	0	probably_damaging	0.94	deleterious	0	neutral	1.81	deleterious	-7.49	deleterious	-6.22	high_impact	4.18	0.54	damaging	0.45	neutral	4.19	23.80	deleterious	0.03	0.35	0.66	disease	0.81	disease	0.73	disease	0.75	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-1.84	low_impact	-1.48	low_impact	3.01	high_impact	0.45	0.8	19.39	22.54	0.4	N	0.83	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11982	11982	T	G	MI.18887	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1223	408	L	R	cTc/cGc	-0.2	0	0	possibly_damaging	0.84	deleterious	0	neutral	1.82	deleterious	-3.11	deleterious	-5.41	high_impact	4.18	0.56	damaging	0.44	neutral	4.30	24.00	deleterious	0.01	0.35	0.75	disease	0.89	disease	0.76	disease	0.79	disease	6	1	deleterious	0.08	neutral	5	deleterious	0.88	deleterious	-1.39	low_impact	-1.48	low_impact	3.01	high_impact	0.16	0.8	19.39	22.54	0.43	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11982	11982	T	C	MI.18888	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1223	408	L	P	cTc/cCc	-0.2	0	0	probably_damaging	0.94	deleterious	0	neutral	1.81	deleterious	-3.09	deleterious	-6.31	high_impact	4.18	0.56	damaging	0.51	neutral	3.97	23.60	deleterious	0.01	0.35	0.52	disease	0.82	disease	0.76	disease	0.76	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.82	deleterious	-1.84	low_impact	-1.48	low_impact	3.01	high_impact	0.51	0.8	19.39	22.54	0.41	N	0.87	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11984	11984	T	G	MI.18889	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1225	409	Y	D	Tac/Gac	-20	0	0	possibly_damaging	0.6	deleterious	0	neutral	2.13	deleterious	-3.55	deleterious	-7.88	high_impact	3.56	0.7	neutral	0.41	neutral	4.00	23.60	deleterious	0.03	0.35	0.53	disease	0.9	disease	0.77	disease	0.81	disease	6	1	deleterious	0.2	neutral	5	deleterious	0.79	deleterious	-0.88	medium_impact	-1.48	low_impact	2.4	high_impact	0.14	0.8	25.05	18.83	0.46	N	1.00	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5909	5909	C	G	MI.1889	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	6	2	F	L	ttC/ttG	1.98	0.98	0	benign	0	neutral	0.64	neutral	2.62	neutral	-2.25	neutral	-0.08	neutral_impact	0.49	0.77	neutral	0.74	neutral	0.03	2.92	deleterious	0.46	0.55	0.2	neutral	0.17	neutral	0.17	neutral	0.17	neutral	7	0.36	neutral	0.82	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.33	medium_impact	-0.65	medium_impact	0.42	0.9	10.14	44.98	0.46	N	0.01	polymorphism	0.85	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11984	11984	T	C	MI.18890	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1225	409	Y	H	Tac/Cac	-20	0	0	benign	0.01	neutral	0.09	neutral	2.14	deleterious	-3.14	deleterious	-2.69	neutral_impact	0.1	0.75	neutral	0.83	neutral	2.31	18.23	deleterious	0.19	0.45	0.67	disease	0.47	neutral	0.56	disease	0.59	disease	2	0.91	neutral	0.54	deleterious	-6	neutral	0.76	deleterious	1.16	medium_impact	-0.36	medium_impact	-1.03	low_impact	0.17	0.8	25.05	18.83	0.43	N	0.42	disease_causing_automatic	0	0.12	rs200911567	Pathogenic	Leigh_syndrome	165637	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	11984	11984	T	A	MI.18891	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1225	409	Y	N	Tac/Aac	-20	0	0	possibly_damaging	0.44	deleterious	0.02	neutral	2.14	neutral	-1.08	deleterious	-6.79	medium_impact	2.87	0.7	neutral	0.65	neutral	4.06	23.70	deleterious	0.07	0.35	0.36	neutral	0.86	disease	0.65	disease	0.67	disease	3	0.98	neutral	0.29	neutral	4	deleterious	0.76	deleterious	-0.62	medium_impact	-0.75	medium_impact	1.71	medium_impact	0.20	0.8	25.05	18.83	0.42	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11985	11985	A	C	MI.18892	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1226	409	Y	S	tAc/tCc	0.26	0	0	possibly_damaging	0.53	deleterious	0.02	neutral	2.18	neutral	0.9	deleterious	-7.07	medium_impact	3.01	0.76	neutral	0.6	neutral	3.78	23.40	deleterious	0.07	0.35	0.47	neutral	0.84	disease	0.57	disease	0.65	disease	3	0.98	neutral	0.25	neutral	4	deleterious	0.77	deleterious	-0.77	medium_impact	-0.75	medium_impact	1.85	medium_impact	0.23	0.8	25.05	18.83	0.36	N	0.94	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11985	11985	A	T	MI.18893	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1226	409	Y	F	tAc/tTc	0.26	0	0	possibly_damaging	0.47	neutral	0.13	neutral	2.18	neutral	-0.03	deleterious	-3.45	medium_impact	2.04	0.74	neutral	0.67	neutral	3.57	23.10	deleterious	0.3	0.45	0.79	disease	0.72	disease	0.6	disease	0.61	disease	2	0.85	neutral	0.33	neutral	0	NA	0.80	deleterious	-0.67	medium_impact	-0.26	medium_impact	0.89	medium_impact	0.31	0.8	25.05	18.83	0.35	N	0.68	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11985	11985	A	G	MI.18894	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1226	409	Y	C	tAc/tGc	0.26	0	0	probably_damaging	0.91	deleterious	0	neutral	2.12	deleterious	-3.06	deleterious	-7.49	high_impact	3.56	0.66	neutral	0.35	neutral	3.64	23.20	deleterious	0.06	0.35	0.94	disease	0.91	disease	0.72	disease	0.84	disease	7	1	deleterious	0.05	neutral	6	deleterious	0.85	deleterious	-1.66	low_impact	-1.48	low_impact	2.4	high_impact	0.05	0.8	25.05	18.83	0.31	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11987	11987	A	C	MI.18895	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1228	410	M	L	Ata/Cta	-6.19	0	0	benign	0.05	neutral	1	neutral	2.45	neutral	1.81	neutral	-2.47	medium_impact	2	0.68	neutral	0.57	neutral	1.69	14.38	neutral	0.25	0.45	0.4	neutral	0.58	disease	0.48	neutral	0.44	neutral	1	0.05	neutral	0.98	deleterious	-3	neutral	0.44	deleterious	0.48	medium_impact	1.88	high_impact	0.85	medium_impact	0.26	0.8	47.71	9.29	0.3	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11987	11987	A	T	MI.18896	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1228	410	M	L	Ata/Tta	-6.19	0	0	benign	0.05	neutral	1	neutral	2.45	neutral	1.81	neutral	-2.47	medium_impact	2	0.68	neutral	0.57	neutral	1.73	14.56	neutral	0.25	0.45	0.4	neutral	0.58	disease	0.48	neutral	0.44	neutral	1	0.05	neutral	0.98	deleterious	-3	neutral	0.44	deleterious	0.48	medium_impact	1.88	high_impact	0.85	medium_impact	0.26	0.8	47.71	9.29	0.31	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11987	11987	A	G	MI.18897	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1228	410	M	V	Ata/Gta	-6.19	0	0	benign	0.07	deleterious	0.03	neutral	2.26	neutral	0.07	deleterious	-3.46	medium_impact	2.29	0.73	neutral	0.63	neutral	2.38	18.66	deleterious	0.28	0.45	0.52	disease	0.74	disease	0.48	neutral	0.52	disease	0	0.97	neutral	0.48	deleterious	1	deleterious	0.54	deleterious	0.34	medium_impact	-0.64	medium_impact	1.14	medium_impact	0.31	0.8	47.71	9.29	0.33	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11988	11988	T	C	MI.18898	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1229	410	M	T	aTa/aCa	5.32	1	0	benign	0.38	deleterious	0	neutral	2.18	neutral	-1.74	deleterious	-5.34	high_impact	3.68	0.69	neutral	0.58	neutral	2.97	22.10	deleterious	0.08	0.35	0.39	neutral	0.81	disease	0.67	disease	0.68	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.70	deleterious	-0.52	medium_impact	-1.48	low_impact	2.52	high_impact	0.12	0.8	47.71	9.29	0.51	P	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11988	11988	T	A	MI.18899	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1229	410	M	K	aTa/aAa	5.32	1	0	possibly_damaging	0.6	deleterious	0	neutral	2.13	neutral	-2.37	deleterious	-5.43	high_impact	4.03	0.68	neutral	0.45	neutral	3.99	23.60	deleterious	0.03	0.35	0.8	disease	0.87	disease	0.74	disease	0.79	disease	6	1	deleterious	0.2	neutral	5	deleterious	0.79	deleterious	-0.88	medium_impact	-1.48	low_impact	2.86	high_impact	0.18	0.8	47.71	9.29	0.61	P	1.00	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8615	8615	T	C	MI.189	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	89	30	L	S	tTg/tCg	-1.95	0	0	probably_damaging	1	neutral	0.08	neutral	4.25	neutral	-1.51	deleterious	-5.13	medium_impact	2.8	0.79	neutral	0.52	neutral	3.62	23.20	deleterious	0.28	0.65	0.48	neutral	0.65	disease	0.28	neutral	0.51	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.31	medium_impact	1.3	medium_impact	0.64	0.9	17.7	14.1	0.36	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5909	5909	C	A	MI.1890	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	6	2	F	L	ttC/ttA	1.98	0.98	0	benign	0	neutral	0.64	neutral	2.62	neutral	-2.25	neutral	-0.08	neutral_impact	0.49	0.77	neutral	0.74	neutral	0.37	6.32	deleterious	0.46	0.55	0.2	neutral	0.17	neutral	0.17	neutral	0.17	neutral	7	0.36	neutral	0.82	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.33	medium_impact	-0.65	medium_impact	0.42	0.9	10.14	44.98	0.46	N	0.01	polymorphism	0.85	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11989	11989	A	C	MI.18900	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1230	410	M	I	atA/atC	7.4	1	0	benign	0.01	neutral	0.15	neutral	2.3	neutral	0.32	deleterious	-3.39	medium_impact	2.01	0.69	neutral	0.63	neutral	3.15	22.60	deleterious	0.25	0.45	0.36	neutral	0.75	disease	0.45	neutral	0.5	disease	0	0.85	neutral	0.57	deleterious	-3	neutral	0.61	deleterious	1.16	medium_impact	-0.22	medium_impact	0.86	medium_impact	0.33	0.8	47.71	9.29	0.61	P	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11989	11989	A	T	MI.18901	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1230	410	M	I	atA/atT	7.4	1	0	benign	0.01	neutral	0.15	neutral	2.3	neutral	0.32	deleterious	-3.39	medium_impact	2.01	0.69	neutral	0.63	neutral	3.24	22.80	deleterious	0.25	0.45	0.36	neutral	0.75	disease	0.45	neutral	0.5	disease	0	0.85	neutral	0.57	deleterious	-3	neutral	0.61	deleterious	1.16	medium_impact	-0.22	medium_impact	0.86	medium_impact	0.33	0.8	47.71	9.29	0.61	P	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11990	11990	T	C	MI.18902	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1231	411	F	L	Ttt/Ctt	-1.12	0	0	benign	0.01	neutral	0.38	neutral	2.28	neutral	-0.06	neutral	-0.72	low_impact	1.51	0.77	neutral	0.95	neutral	0.26	5.26	deleterious	0.26	0.45	0.43	neutral	0.43	neutral	0.4	neutral	0.44	neutral	1	0.61	neutral	0.69	deleterious	-6	neutral	0.16	neutral	1.16	medium_impact	0.08	medium_impact	0.37	medium_impact	0.79	0.85	30.94	28.83	0.41	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11990	11990	T	A	MI.18903	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1231	411	F	I	Ttt/Att	-1.12	0	0	benign	0.14	neutral	0.09	neutral	2.25	neutral	-0.49	neutral	-1.5	medium_impact	3.17	0.79	neutral	0.84	neutral	1.47	13.15	neutral	0.18	0.45	0.44	neutral	0.73	disease	0.54	disease	0.61	disease	2	0.9	neutral	0.48	deleterious	-3	neutral	0.24	neutral	0.02	medium_impact	-0.36	medium_impact	2.01	high_impact	0.60	0.8	30.94	28.83	0.41	N	0.18	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11990	11990	T	G	MI.18904	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1231	411	F	V	Ttt/Gtt	-1.12	0	0	benign	0.22	deleterious	0.02	neutral	2.22	neutral	-0.63	neutral	-2.39	medium_impact	3.42	0.74	neutral	0.58	neutral	2.11	16.94	deleterious	0.12	0.4	0.55	disease	0.79	disease	0.63	disease	0.68	disease	4	0.98	neutral	0.4	neutral	1	deleterious	0.27	neutral	-0.2	medium_impact	-0.75	medium_impact	2.26	high_impact	0.50	0.8	30.94	28.83	0.37	N	0.52	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11991	11991	T	A	MI.18905	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1232	411	F	Y	tTt/tAt	-0.43	0	0	benign	0.01	neutral	1	neutral	2.3	neutral	-0.31	neutral	-1.61	low_impact	1.7	0.77	neutral	0.77	neutral	2.54	19.74	deleterious	0.16	0.45	0.59	disease	0.43	neutral	0.38	neutral	0.59	disease	2	0.01	neutral	1	deleterious	-6	neutral	0.41	neutral	1.16	medium_impact	1.88	high_impact	0.56	medium_impact	0.70	0.85	30.94	28.83	0.23	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11991	11991	T	G	MI.18906	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1232	411	F	C	tTt/tGt	-0.43	0	0	possibly_damaging	0.86	deleterious	0	neutral	2.09	deleterious	-3.59	deleterious	-3.89	high_impact	3.97	0.76	neutral	0.47	neutral	3.86	23.50	deleterious	0.04	0.35	0.91	disease	0.86	disease	0.67	disease	0.8	disease	6	1	deleterious	0.07	neutral	5	deleterious	0.69	deleterious	-1.46	low_impact	-1.48	low_impact	2.8	high_impact	0.37	0.8	30.94	28.83	0.41	N	0.71	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11991	11991	T	C	MI.18907	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1232	411	F	S	tTt/tCt	-0.43	0	0	possibly_damaging	0.48	neutral	0.05	neutral	2.11	neutral	-2.38	deleterious	-4.37	high_impact	3.97	0.74	neutral	0.56	neutral	2.63	20.40	deleterious	0.04	0.35	0.43	neutral	0.8	disease	0.65	disease	0.68	disease	4	0.94	neutral	0.29	neutral	1	deleterious	0.45	deleterious	-0.69	medium_impact	-0.52	medium_impact	2.8	high_impact	0.50	0.8	30.94	28.83	0.52	N	0.82	polymorphism	1	0.15	.	.	.	.	.	.	COSM1132242	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11992	11992	T	A	MI.18908	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1233	411	F	L	ttT/ttA	7.4	0.95	0	benign	0.01	neutral	0.38	neutral	2.28	neutral	-0.06	neutral	-0.72	low_impact	1.51	0.77	neutral	0.95	neutral	0.67	8.65	deleterious	0.26	0.45	0.43	neutral	0.43	neutral	0.4	neutral	0.44	neutral	1	0.61	neutral	0.69	deleterious	-6	neutral	0.16	neutral	1.16	medium_impact	0.08	medium_impact	0.37	medium_impact	0.79	0.85	30.94	28.83	0.52	P	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11992	11992	T	G	MI.18909	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1233	411	F	L	ttT/ttG	7.4	0.95	0	benign	0.01	neutral	0.38	neutral	2.28	neutral	-0.06	neutral	-0.72	low_impact	1.51	0.77	neutral	0.95	neutral	0.56	7.86	deleterious	0.26	0.45	0.43	neutral	0.43	neutral	0.4	neutral	0.44	neutral	1	0.61	neutral	0.69	deleterious	-6	neutral	0.16	neutral	1.16	medium_impact	0.08	medium_impact	0.37	medium_impact	0.79	0.85	30.94	28.83	0.52	P	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5910	5910	G	C	MI.1891	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	7	3	A	P	Gcc/Ccc	-0.57	0	0	benign	0.16	neutral	0.06	neutral	2.9	neutral	-2.17	neutral	-0.08	low_impact	0.9	0.65	neutral	0.8	neutral	0.60	8.17	deleterious	0.21	0.55	0.47	neutral	0.22	neutral	0.07	neutral	0.31	neutral	4	0.93	neutral	0.45	neutral	-6	neutral	0.26	neutral	-0.08	medium_impact	-0.47	medium_impact	-0.27	medium_impact	0.69	0.9	11.5	19.25	0.63	P	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11993	11993	A	T	MI.18910	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1234	412	T	S	Acc/Tcc	-5.5	0	0	benign	0.21	neutral	0.43	neutral	2.32	neutral	-0.42	neutral	-1.26	neutral_impact	0.8	0.69	neutral	0.99	neutral	1.51	13.34	neutral	0.24	0.45	0.72	disease	0.13	neutral	0.13	neutral	0.46	neutral	1	0.48	neutral	0.61	deleterious	-6	neutral	0.24	neutral	-0.18	medium_impact	0.13	medium_impact	-0.33	medium_impact	0.49	0.8	19.39	15.49	0.44	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11993	11993	A	G	MI.18911	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1234	412	T	A	Acc/Gcc	-5.5	0	0	benign	0.08	neutral	0.51	neutral	2.3	neutral	-0.76	neutral	-0.55	low_impact	1.29	0.71	neutral	0.84	neutral	1.65	14.13	neutral	0.16	0.45	0.61	disease	0.25	neutral	0.31	neutral	0.54	disease	1	0.42	neutral	0.72	deleterious	-6	neutral	0.18	neutral	0.28	medium_impact	0.21	medium_impact	0.15	medium_impact	0.26	0.8	19.39	15.49	0.38	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11993	11993	A	C	MI.18912	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1234	412	T	P	Acc/Ccc	-5.5	0	0	possibly_damaging	0.6	neutral	0.2	neutral	2.24	neutral	-2.71	neutral	-2.31	medium_impact	2.79	0.67	neutral	0.45	neutral	1.81	15.03	deleterious	0.06	0.35	0.87	disease	0.76	disease	0.56	disease	0.79	disease	6	0.81	neutral	0.3	neutral	0	NA	0.55	deleterious	-0.88	medium_impact	-0.14	medium_impact	1.63	medium_impact	0.32	0.8	19.39	15.49	0.33	N	0.82	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11994	11994	C	A	MI.18913	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1235	412	T	N	aCc/aAc	0.49	0	0	possibly_damaging	0.6	neutral	0.31	neutral	2.29	neutral	-0.5	neutral	-2.22	medium_impact	2.79	0.69	neutral	0.62	neutral	1.92	15.71	deleterious	0.24	0.45	0.9	disease	0.6	disease	0.41	neutral	0.65	disease	3	0.71	neutral	0.36	neutral	0	NA	0.48	deleterious	-0.88	medium_impact	0.01	medium_impact	1.63	medium_impact	0.41	0.8	19.39	15.49	0.39	N	0.67	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11994	11994	C	T	MI.18914	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1235	412	T	I	aCc/aTc	0.49	0	0	benign	0	neutral	0.4	neutral	2.29	neutral	-0.99	neutral	2.51	neutral_impact	0.02	0.75	neutral	0.98	neutral	-0.24	0.90	neutral	0.11	0.4	0.36	neutral	0.25	neutral	0.13	neutral	0.45	neutral	1	0.6	neutral	0.7	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.1	medium_impact	-1.11	low_impact	0.59	0.8	19.39	15.49	0.52	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	C11994T	Oligoasthenoteratozoospermia (OAT)	+	-	Conflicting reports	2	.	N	N	neutral
chrM	11994	11994	C	G	MI.18915	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1235	412	T	S	aCc/aGc	0.49	0	0	benign	0.21	neutral	0.43	neutral	2.32	neutral	-0.42	neutral	-1.26	neutral_impact	0.8	0.69	neutral	0.99	neutral	1.73	14.55	neutral	0.24	0.45	0.72	disease	0.13	neutral	0.13	neutral	0.46	neutral	1	0.48	neutral	0.61	deleterious	-6	neutral	0.24	neutral	-0.18	medium_impact	0.13	medium_impact	-0.33	medium_impact	0.49	0.8	19.39	15.49	0.45	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11996	11996	A	C	MI.18916	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1237	413	T	P	Aca/Cca	-9.41	0	0	benign	0.4	neutral	0.17	neutral	2.24	neutral	-1.31	deleterious	-2.97	medium_impact	3.38	0.68	neutral	0.34	neutral	1.98	16.09	deleterious	0.05	0.35	0.85	disease	0.82	disease	0.56	disease	0.76	disease	5	0.8	neutral	0.39	neutral	-3	neutral	0.71	deleterious	-0.55	medium_impact	-0.18	medium_impact	2.22	high_impact	0.35	0.8	15.03	13.44	0.32	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11996	11996	A	G	MI.18917	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1237	413	T	A	Aca/Gca	-9.41	0	0	benign	0.11	neutral	0.47	neutral	2.3	neutral	0.31	neutral	-1.78	low_impact	1.79	0.76	neutral	0.81	neutral	0.57	7.92	deleterious	0.22	0.45	0.55	disease	0.35	neutral	0.24	neutral	0.61	disease	2	0.46	neutral	0.68	deleterious	-6	neutral	0.26	neutral	0.14	medium_impact	0.17	medium_impact	0.65	medium_impact	0.37	0.8	15.03	13.44	0.38	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11996	11996	A	T	MI.18918	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1237	413	T	S	Aca/Tca	-9.41	0	0	benign	0.01	neutral	0.54	neutral	2.33	neutral	-0.01	neutral	-0.98	neutral_impact	0.24	0.72	neutral	0.98	neutral	0.30	5.71	deleterious	0.31	0.45	0.61	disease	0.26	neutral	0.18	neutral	0.56	disease	1	0.44	neutral	0.77	deleterious	-6	neutral	0.31	neutral	1.16	medium_impact	0.24	medium_impact	-0.89	medium_impact	0.63	0.8	15.03	13.44	0.43	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11997	11997	C	A	MI.18919	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1238	413	T	K	aCa/aAa	1.87	0	0	benign	0.16	neutral	0.27	neutral	2.32	neutral	0.09	neutral	-2.45	medium_impact	3.03	0.71	neutral	0.44	neutral	2.68	20.70	deleterious	0.09	0.4	0.81	disease	0.69	disease	0.54	disease	0.65	disease	3	0.68	neutral	0.56	deleterious	-3	neutral	0.49	deleterious	-0.04	medium_impact	-0.04	medium_impact	1.87	medium_impact	0.36	0.8	15.03	13.44	0.36	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5910	5910	G	T	MI.1892	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	7	3	A	S	Gcc/Tcc	-0.57	0	0	benign	0.04	neutral	0.14	neutral	2.96	neutral	-0.68	neutral	-0.03	neutral_impact	0.34	0.7	neutral	0.8	neutral	0.31	5.77	deleterious	0.45	0.55	0.26	neutral	0.03	neutral	0.06	neutral	0.1	neutral	8	0.85	neutral	0.55	deleterious	-6	neutral	0.10	neutral	0.54	medium_impact	-0.25	medium_impact	-0.79	medium_impact	0.67	0.9	11.5	19.25	0.66	P	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11997	11997	C	T	MI.18920	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1238	413	T	M	aCa/aTa	1.87	0	0	benign	0.03	neutral	0.39	neutral	2.28	neutral	0.18	neutral	-0.56	neutral_impact	0.74	0.75	neutral	0.98	neutral	-0.53	0.19	neutral	0.14	0.4	0.43	neutral	0.1	neutral	0.18	neutral	0.31	neutral	4	0.59	neutral	0.68	deleterious	-6	neutral	0.14	neutral	0.7	medium_impact	0.09	medium_impact	-0.39	medium_impact	0.61	0.8	15.03	13.44	0.56	P	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	11999	11999	A	G	MI.18921	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1240	414	T	A	Aca/Gca	-1.12	0	0	benign	0.22	deleterious	0.04	neutral	2.11	neutral	-1.79	deleterious	-3.77	medium_impact	3.12	0.73	neutral	0.66	neutral	3.58	23.20	deleterious	0.27	0.45	0.46	neutral	0.58	disease	0.54	disease	0.53	disease	1	0.95	neutral	0.41	neutral	1	deleterious	0.72	deleterious	-0.2	medium_impact	-0.57	medium_impact	1.96	medium_impact	0.44	0.8	23.75	20.1	0.45	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11999	11999	A	C	MI.18922	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1240	414	T	P	Aca/Cca	-1.12	0	0	possibly_damaging	0.87	deleterious	0.02	neutral	2.02	deleterious	-5.7	deleterious	-4.86	high_impact	4.01	0.68	neutral	0.39	neutral	3.59	23.20	deleterious	0.03	0.35	0.5	neutral	0.84	disease	0.76	disease	0.77	disease	5	0.99	deleterious	0.08	neutral	5	deleterious	0.79	deleterious	-1.49	low_impact	-0.75	medium_impact	2.84	high_impact	0.33	0.8	23.75	20.1	0.46	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	11999	11999	A	T	MI.18923	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1240	414	T	S	Aca/Tca	-1.12	0	0	possibly_damaging	0.47	neutral	0.5	neutral	2.08	neutral	-1.6	deleterious	-2.75	medium_impact	2.04	0.68	neutral	0.84	neutral	2.22	17.67	deleterious	0.32	0.5	0.7	disease	0.3	neutral	0.3	neutral	0.59	disease	2	0.48	neutral	0.52	deleterious	0	NA	0.73	deleterious	-0.67	medium_impact	0.2	medium_impact	0.89	medium_impact	0.62	0.8	23.75	20.1	0.37	N	0.39	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12000	12000	C	T	MI.18924	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1241	414	T	M	aCa/aTa	4.4	0.96	0	benign	0.07	neutral	0.07	neutral	2.09	neutral	-0.24	deleterious	-4.73	medium_impact	2.56	0.73	neutral	0.56	neutral	4.03	23.60	deleterious	0.09	0.35	0.77	disease	0.74	disease	0.65	disease	0.64	disease	3	0.92	neutral	0.5	deleterious	-3	neutral	0.78	deleterious	0.34	medium_impact	-0.43	medium_impact	1.41	medium_impact	0.52	0.8	23.75	20.1	0.48	P	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12000	12000	C	A	MI.18925	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1241	414	T	K	aCa/aAa	4.4	0.96	0	possibly_damaging	0.6	deleterious	0.01	neutral	2.03	deleterious	-4.65	deleterious	-4.74	high_impact	4.01	0.71	neutral	0.42	neutral	4.57	24.40	deleterious	0.05	0.35	0.85	disease	0.82	disease	0.75	disease	0.81	disease	6	0.99	deleterious	0.21	neutral	5	deleterious	0.84	deleterious	-0.88	medium_impact	-0.92	medium_impact	2.84	high_impact	0.28	0.8	23.75	20.1	0.58	P	0.93	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12002	12002	C	A	MI.18926	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1243	415	Q	K	Caa/Aaa	-5.96	0	0	probably_damaging	0.99	deleterious	0.02	neutral	2.22	neutral	-2.7	deleterious	-3.66	high_impact	4.21	0.71	neutral	0.12	damaging	4.05	23.70	deleterious	0.18	0.45	0.4	neutral	0.8	disease	0.69	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.59	low_impact	-0.75	medium_impact	3.04	high_impact	0.26	0.8	46.62	9.42	0.36	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12002	12002	C	G	MI.18927	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1243	415	Q	E	Caa/Gaa	-5.96	0	0	probably_damaging	0.98	deleterious	0.02	neutral	2.22	neutral	-2.75	deleterious	-2.75	high_impact	4.21	0.72	neutral	0.14	damaging	3.10	22.50	deleterious	0.3	0.45	0.81	disease	0.75	disease	0.76	disease	0.79	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.31	low_impact	-0.75	medium_impact	3.04	high_impact	0.33	0.8	46.62	9.42	0.39	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12003	12003	A	G	MI.18928	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1244	415	Q	R	cAa/cGa	7.17	1	0	probably_damaging	0.99	neutral	0.08	neutral	2.23	neutral	-1.07	deleterious	-3.66	high_impact	4.21	0.7	neutral	0.12	damaging	3.44	23.00	deleterious	0.18	0.45	0.78	disease	0.84	disease	0.78	disease	0.8	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	-0.39	medium_impact	3.04	high_impact	0.12	0.8	46.62	9.42	0.69	P	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12003	12003	A	T	MI.18929	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1244	415	Q	L	cAa/cTa	7.17	1	0	probably_damaging	0.99	neutral	0.07	neutral	2.33	neutral	-2.52	deleterious	-6.41	high_impact	3.86	0.63	neutral	0.13	damaging	3.77	23.40	deleterious	0.1	0.4	0.42	neutral	0.87	disease	0.68	disease	0.73	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.77	deleterious	-2.59	low_impact	-0.43	medium_impact	2.69	high_impact	0.05	0.8	46.62	9.42	0.61	P	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5910	5910	G	A	MI.1893	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	7	3	A	T	Gcc/Acc	-0.57	0	0	benign	0.02	neutral	0.09	neutral	2.97	neutral	-0.4	neutral	0.02	low_impact	1.25	0.8	neutral	0.94	neutral	1.08	11.09	neutral	0.4	0.55	0.22	neutral	0.05	neutral	0.06	neutral	0.1	neutral	8	0.91	neutral	0.54	deleterious	-6	neutral	0.07	neutral	0.83	medium_impact	-0.37	medium_impact	0.06	medium_impact	0.70	0.9	11.5	19.25	0.63	P	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12003	12003	A	C	MI.18930	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1244	415	Q	P	cAa/cCa	7.17	1	0	probably_damaging	1	deleterious	0.01	neutral	2.21	deleterious	-4.42	deleterious	-5.5	high_impact	4.21	0.68	neutral	0.14	damaging	3.35	22.90	deleterious	0.03	0.35	0.66	disease	0.83	disease	0.79	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-0.92	medium_impact	3.04	high_impact	0.22	0.8	46.62	9.42	0.62	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12004	12004	A	C	MI.18931	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1245	415	Q	H	caA/caC	8.55	1	0	probably_damaging	1	deleterious	0.04	neutral	2.21	deleterious	-4.21	deleterious	-4.58	medium_impact	3.11	0.67	neutral	0.12	damaging	3.66	23.20	deleterious	0.18	0.45	0.83	disease	0.78	disease	0.67	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-0.57	medium_impact	1.95	medium_impact	0.44	0.8	46.62	9.42	0.56	P	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12004	12004	A	T	MI.18932	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1245	415	Q	H	caA/caT	8.55	1	0	probably_damaging	1	deleterious	0.04	neutral	2.21	deleterious	-4.21	deleterious	-4.58	medium_impact	3.11	0.67	neutral	0.12	damaging	3.75	23.30	deleterious	0.18	0.45	0.83	disease	0.78	disease	0.67	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-3.54	low_impact	-0.57	medium_impact	1.95	medium_impact	0.44	0.8	46.62	9.42	0.56	P	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12005	12005	T	C	MI.18933	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1246	416	W	R	Tgg/Cgg	2.56	1	0	benign	0	neutral	0.77	neutral	2.33	neutral	-1.49	neutral	6.47	neutral_impact	-2.27	0.76	neutral	0.9	neutral	-0.93	0.02	neutral	0.06	0.35	0.59	disease	0.1	neutral	0.28	neutral	0.29	neutral	4	0.23	neutral	0.89	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	0.5	medium_impact	-3.37	low_impact	0.09	0.8	42.7	8.57	0.4	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	COSM1497298	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12005	12005	T	G	MI.18934	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1246	416	W	G	Tgg/Ggg	2.56	1	0	benign	0.04	deleterious	0.04	neutral	2.29	neutral	-1.49	neutral	0.49	low_impact	0.98	0.74	neutral	0.53	neutral	2.11	16.91	deleterious	0.08	0.35	0.86	disease	0.45	neutral	0.68	disease	0.69	disease	4	0.96	neutral	0.5	deleterious	-2	neutral	0.29	neutral	0.58	medium_impact	-0.57	medium_impact	-0.16	medium_impact	0.10	0.8	42.7	8.57	0.46	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12006	12006	G	C	MI.18935	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1247	416	W	S	tGg/tCg	2.33	1	0	benign	0.03	neutral	0.12	neutral	2.33	neutral	-0.7	neutral	1.37	low_impact	1.52	0.75	neutral	0.6	neutral	2.20	17.53	deleterious	0.09	0.35	0.72	disease	0.45	neutral	0.57	disease	0.67	disease	3	0.87	neutral	0.55	deleterious	-6	neutral	0.27	neutral	0.7	medium_impact	-0.28	medium_impact	0.38	medium_impact	0.09	0.8	42.7	8.57	0.51	P	0.38	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12006	12006	G	T	MI.18936	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1247	416	W	L	tGg/tTg	2.33	1	0	benign	0.02	neutral	0.1	neutral	2.35	neutral	0.49	neutral	0.49	low_impact	0.83	0.74	neutral	0.56	neutral	2.43	19.02	deleterious	0.1	0.4	0.59	disease	0.39	neutral	0.6	disease	0.64	disease	3	0.9	neutral	0.54	deleterious	-6	neutral	0.21	neutral	0.87	medium_impact	-0.33	medium_impact	-0.31	medium_impact	0.04	0.8	42.7	8.57	0.5	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12007	12007	G	C	MI.18937	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1248	416	W	C	tgG/tgC	1.64	0.97	0.03	possibly_damaging	0.54	deleterious	0.02	neutral	2.26	neutral	-2.69	neutral	-0.26	low_impact	1.52	0.81	neutral	0.43	neutral	2.49	19.39	deleterious	0.07	0.35	0.74	disease	0.63	disease	0.52	disease	0.59	disease	2	0.98	neutral	0.24	neutral	1	deleterious	0.57	deleterious	-0.78	medium_impact	-0.75	medium_impact	0.38	medium_impact	0.07	0.8	42.7	8.57	0.4	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12007	12007	G	T	MI.18938	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1248	416	W	C	tgG/tgT	1.64	0.97	0.03	possibly_damaging	0.54	deleterious	0.02	neutral	2.26	neutral	-2.69	neutral	-0.26	low_impact	1.52	0.81	neutral	0.43	neutral	2.60	20.20	deleterious	0.07	0.35	0.74	disease	0.63	disease	0.52	disease	0.59	disease	2	0.98	neutral	0.24	neutral	1	deleterious	0.57	deleterious	-0.78	medium_impact	-0.75	medium_impact	0.38	medium_impact	0.07	0.8	42.7	8.57	0.41	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12008	12008	G	A	MI.18939	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1249	417	G	S	Ggc/Agc	-2.04	0	0	possibly_damaging	0.84	neutral	0.06	neutral	1.84	neutral	-2.9	deleterious	-5.26	medium_impact	2.6	0.7	neutral	0.47	neutral	4.28	24.00	deleterious	0.11	0.4	0.72	disease	0.77	disease	0.26	neutral	0.47	neutral	1	0.97	neutral	0.11	neutral	0	NA	0.83	deleterious	-1.39	low_impact	-0.47	medium_impact	1.45	medium_impact	0.48	0.8	47.71	9.31	0.45	N	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5911	5911	C	A	MI.1894	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	8	3	A	D	gCc/gAc	-0.11	0	0	benign	0.16	deleterious	0	neutral	2.9	neutral	-2.3	neutral	-0.21	low_impact	1.25	0.6	damaging	0.58	neutral	2.59	20.10	deleterious	0.29	0.55	0.53	disease	0.22	neutral	0.22	neutral	0.24	neutral	5	1	deleterious	0.42	neutral	-2	neutral	0.20	neutral	-0.08	medium_impact	-1.48	low_impact	0.06	medium_impact	0.48	0.9	11.5	19.25	0.52	P	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12008	12008	G	T	MI.18940	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1249	417	G	C	Ggc/Tgc	-2.04	0	0	probably_damaging	1	deleterious	0	neutral	1.76	deleterious	-5.98	deleterious	-8.04	high_impact	4.05	0.7	neutral	0.3	neutral	4.35	24.10	deleterious	0.06	0.35	0.87	disease	0.91	disease	0.62	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-1.48	low_impact	2.88	high_impact	0.11	0.8	47.71	9.31	0.35	N	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12008	12008	G	C	MI.18941	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1249	417	G	R	Ggc/Cgc	-2.04	0	0	probably_damaging	0.92	deleterious	0.01	neutral	1.81	deleterious	-3.42	deleterious	-7.02	high_impact	3.7	0.72	neutral	0.31	neutral	4.11	23.70	deleterious	0.06	0.35	0.94	disease	0.9	disease	0.7	disease	0.83	disease	7	1	deleterious	0.05	neutral	6	deleterious	0.91	deleterious	-1.71	low_impact	-0.92	medium_impact	2.53	high_impact	0.44	0.8	47.71	9.31	0.33	N	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12009	12009	G	A	MI.18942	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1250	417	G	D	gGc/gAc	6.01	1	0	possibly_damaging	0.89	deleterious	0	neutral	1.8	deleterious	-3.58	deleterious	-6.15	high_impact	4.05	0.74	neutral	0.34	neutral	3.92	23.50	deleterious	0.05	0.35	0.97	disease	0.87	disease	0.68	disease	0.83	disease	7	1	deleterious	0.06	neutral	5	deleterious	0.87	deleterious	-1.57	low_impact	-1.48	low_impact	2.88	high_impact	0.11	0.8	47.71	9.31	0.64	P	0.99	polymorphism	1	0.34	.	.	.	.	.	.	COSM488730	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12009	12009	G	C	MI.18943	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1250	417	G	A	gGc/gCc	6.01	1	0	possibly_damaging	0.75	deleterious	0	neutral	1.85	neutral	-2.68	deleterious	-5.36	medium_impact	3.25	0.71	neutral	0.47	neutral	3.26	22.80	deleterious	0.13	0.4	0.54	disease	0.7	disease	0.58	disease	0.64	disease	3	1	deleterious	0.13	neutral	4	deleterious	0.79	deleterious	-1.17	low_impact	-1.48	low_impact	2.09	high_impact	0.19	0.8	47.71	9.31	0.61	P	0.76	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12009	12009	G	T	MI.18944	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1250	417	G	V	gGc/gTc	6.01	1	0	probably_damaging	0.96	deleterious	0	neutral	1.82	deleterious	-3.3	deleterious	-8.04	high_impact	4.05	0.71	neutral	0.38	neutral	3.95	23.60	deleterious	0.05	0.35	0.8	disease	0.86	disease	0.61	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.01	low_impact	-1.48	low_impact	2.88	high_impact	0.07	0.8	47.71	9.31	0.62	P	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12011	12011	T	C	MI.18945	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1252	418	S	P	Tca/Cca	-20	0	0	benign	0	neutral	0.52	neutral	2.27	neutral	1.09	neutral	0.85	neutral_impact	-1.29	0.76	neutral	0.89	neutral	-0.56	0.16	neutral	0.2	0.45	0.84	disease	0.32	neutral	0.07	neutral	0.66	disease	3	0.48	neutral	0.76	deleterious	-6	neutral	0.24	neutral	2.1	high_impact	0.22	medium_impact	-2.4	low_impact	0.15	0.8	26.58	34.23	0.4	N	0.12	polymorphism	1	0.00	rs386829144	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12011	12011	T	A	MI.18946	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1252	418	S	T	Tca/Aca	-20	0	0	benign	0	neutral	0.43	neutral	2.28	neutral	1.33	neutral	-0.35	neutral_impact	-1.27	0.78	neutral	0.87	neutral	0.80	9.49	deleterious	0.6	0.65	0.55	disease	0.26	neutral	0.08	neutral	0.55	disease	1	0.57	neutral	0.72	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	0.13	medium_impact	-2.38	low_impact	0.37	0.8	26.58	34.23	0.46	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12011	12011	T	G	MI.18947	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1252	418	S	A	Tca/Gca	-20	0	0	benign	0	neutral	0.47	neutral	2.29	neutral	0.84	neutral	-0.74	neutral_impact	-0.38	0.8	neutral	0.9	neutral	0.86	9.80	deleterious	0.64	0.7	0.53	disease	0.26	neutral	0.16	neutral	0.41	neutral	2	0.53	neutral	0.74	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	0.17	medium_impact	-1.5	low_impact	0.24	0.8	26.58	34.23	0.45	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12012	12012	C	G	MI.18948	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1253	418	S	W	tCa/tGa	0.26	0	0	benign	0.26	deleterious	0.03	neutral	2.19	deleterious	-4.96	deleterious	-2.73	low_impact	1.45	0.77	neutral	0.45	neutral	2.58	19.96	deleterious	0.11	0.4	0.92	disease	0.75	disease	0.43	neutral	0.79	disease	6	0.97	neutral	0.39	neutral	-2	neutral	0.53	deleterious	-0.29	medium_impact	-0.64	medium_impact	0.31	medium_impact	0.12	0.8	26.58	34.23	0.32	N	0.56	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12012	12012	C	T	MI.18949	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1253	418	S	L	tCa/tTa	0.26	0	0	benign	0	neutral	0.26	neutral	2.22	neutral	-1.86	neutral	-1.57	neutral_impact	0.47	0.8	neutral	0.78	neutral	1.75	14.71	neutral	0.25	0.45	0.35	neutral	0.54	disease	0.22	neutral	0.44	neutral	1	0.74	neutral	0.63	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	-0.05	medium_impact	-0.66	medium_impact	0.43	0.8	26.58	34.23	0.39	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5911	5911	C	T	MI.1895	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	8	3	A	V	gCc/gTc	-0.11	0	0	benign	0	neutral	0.11	neutral	3.05	neutral	0.55	neutral	0.15	neutral_impact	0.2	0.89	neutral	0.98	neutral	0.99	10.61	neutral	0.34	0.55	0.25	neutral	0.05	neutral	0.07	neutral	0.11	neutral	8	0.89	neutral	0.56	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	-0.31	medium_impact	-0.91	medium_impact	0.80	0.9	11.5	19.25	0.68	P	0.00	polymorphism	1	0.00	rs879227822	.	.	.	.	.	.	.	.	C5911T	Prostate Cancer	+	-	Reported	1	N	P	N,P	neutral
chrM	12014	12014	C	A	MI.18950	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1255	419	L	I	Ctc/Atc	-1.81	0	0	benign	0.31	neutral	0.54	neutral	2.13	neutral	-2.67	neutral	-0.59	medium_impact	2.08	0.77	neutral	0.82	neutral	1.02	10.79	neutral	0.48	0.55	0.44	neutral	0.3	neutral	0.17	neutral	0.47	neutral	1	0.37	neutral	0.62	deleterious	-3	neutral	0.31	neutral	-0.39	medium_impact	0.24	medium_impact	0.93	medium_impact	0.38	0.8	29.63	25.35	0.4	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12014	12014	C	G	MI.18951	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1255	419	L	V	Ctc/Gtc	-1.81	0	0	benign	0.31	neutral	0.53	neutral	2.17	deleterious	-3.17	neutral	-0.7	medium_impact	2.62	0.76	neutral	0.77	neutral	0.27	5.45	deleterious	0.46	0.55	0.45	neutral	0.3	neutral	0.2	neutral	0.47	neutral	1	0.38	neutral	0.61	deleterious	-3	neutral	0.20	neutral	-0.39	medium_impact	0.23	medium_impact	1.47	medium_impact	0.33	0.8	29.63	25.35	0.39	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12014	12014	C	T	MI.18952	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1255	419	L	F	Ctc/Ttc	-1.81	0	0	benign	0.03	neutral	0.78	neutral	2.1	neutral	-2.1	neutral	-1.15	medium_impact	2.31	0.83	neutral	0.92	neutral	0.98	10.54	neutral	0.45	0.55	0.53	disease	0.35	neutral	0.2	neutral	0.42	neutral	2	0.16	neutral	0.88	deleterious	-3	neutral	0.52	deleterious	0.7	medium_impact	0.51	medium_impact	1.16	medium_impact	0.40	0.8	29.63	25.35	0.34	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12015	12015	T	C	MI.18953	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1256	419	L	P	cTc/cCc	-6.19	0	0	benign	0.01	neutral	0.33	neutral	2.08	neutral	-0.73	neutral	-2.12	low_impact	1.21	0.81	neutral	0.94	neutral	0.79	9.43	deleterious	0.14	0.4	0.94	disease	0.65	disease	0.21	neutral	0.7	disease	4	0.66	neutral	0.66	deleterious	-6	neutral	0.30	neutral	1.16	medium_impact	0.03	medium_impact	0.07	medium_impact	0.19	0.8	29.63	25.35	0.31	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	COSM1138244	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12015	12015	T	G	MI.18954	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1256	419	L	R	cTc/cGc	-6.19	0	0	possibly_damaging	0.82	neutral	0.29	neutral	2.06	neutral	-0.92	deleterious	-2.67	high_impact	3.66	0.7	neutral	0.49	neutral	1.63	14.04	neutral	0.11	0.4	0.91	disease	0.78	disease	0.5	neutral	0.72	disease	4	0.86	neutral	0.24	neutral	1	deleterious	0.64	deleterious	-1.34	low_impact	-0.02	medium_impact	2.5	high_impact	0.16	0.8	29.63	25.35	0.39	N	0.57	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12015	12015	T	A	MI.18955	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1256	419	L	H	cTc/cAc	-6.19	0	0	probably_damaging	0.91	neutral	0.52	neutral	2.03	deleterious	-3.3	deleterious	-2.7	medium_impact	2.77	0.82	neutral	0.84	neutral	2.84	21.60	deleterious	0.17	0.45	0.94	disease	0.63	disease	0.27	neutral	0.69	disease	4	0.9	neutral	0.31	neutral	1	deleterious	0.69	deleterious	-1.66	low_impact	0.22	medium_impact	1.61	medium_impact	0.12	0.8	29.63	25.35	0.3	N	0.52	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12017	12017	A	C	MI.18956	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1258	420	T	P	Acc/Ccc	-7.34	0	0	possibly_damaging	0.6	neutral	0.38	neutral	2.23	neutral	1.42	neutral	-0.34	neutral_impact	0.74	0.64	neutral	0.9	neutral	-0.85	0.03	neutral	0.15	0.4	0.88	disease	0.07	neutral	0.13	neutral	0.4	neutral	2	0.65	neutral	0.39	neutral	-3	neutral	0.51	deleterious	-0.88	medium_impact	0.08	medium_impact	-0.39	medium_impact	0.33	0.8	15.9	10.5	0.49	N	0.56	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12017	12017	A	G	MI.18957	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1258	420	T	A	Acc/Gcc	-7.34	0	0	benign	0.01	neutral	0.46	neutral	2.28	neutral	0.52	neutral	-2.14	medium_impact	2.22	0.77	neutral	0.7	neutral	1.65	14.12	neutral	0.49	0.55	0.82	disease	0.27	neutral	0.55	disease	0.6	disease	2	0.53	neutral	0.73	deleterious	-3	neutral	0.28	neutral	1.16	medium_impact	0.16	medium_impact	1.07	medium_impact	0.28	0.8	15.9	10.5	0.3	N	0.84	polymorphism	1	0.03	rs879136236	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12017	12017	A	T	MI.18958	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1258	420	T	S	Acc/Tcc	-7.34	0	0	benign	0.02	neutral	0.47	neutral	2.3	neutral	0.38	neutral	-1.28	low_impact	1.4	0.73	neutral	0.96	neutral	0.22	4.85	deleterious	0.71	0.75	0.51	disease	0.23	neutral	0.21	neutral	0.35	neutral	3	0.51	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.87	medium_impact	0.17	medium_impact	0.26	medium_impact	0.55	0.8	15.9	10.5	0.44	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12018	12018	C	G	MI.18959	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1259	420	T	S	aCc/aGc	0.26	0	0	benign	0.02	neutral	0.47	neutral	2.3	neutral	0.38	neutral	-1.28	low_impact	1.4	0.73	neutral	0.96	neutral	0.46	7.11	deleterious	0.71	0.75	0.51	disease	0.23	neutral	0.21	neutral	0.35	neutral	3	0.51	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.87	medium_impact	0.17	medium_impact	0.26	medium_impact	0.55	0.8	15.9	10.5	0.44	N	0.36	polymorphism	1	0.02	rs1057516068	Uncertain_significance	Microcephaly|Macrocephaly|Hearing_impairment|Dementia|Muscular_hypotonia|Encephalopathy|Seizure_Disorders|Leigh_syndrome|Developmental_delay|Calcification_of_extrapyramidal_basal_ganglia|Congenital_cardiomyopathy	354287	Human_Phenotype_Ontology:HP:0000252,MedGen:C0424688|Human_Phenotype_Ontology:HP:0000256,MedGen:C2243051,OMIM:248000|Human_Phenotype_Ontology:HP:0000365,MedGen:C0018772|Human_Phenotype_Ontology:HP:0000726,MedGen:C0497327|Human_Phenotype_Ontology:HP:0001252,MedGen:C0026827|Human_Phenotype_Ontology:HP:0001298,MedGen:C1963101|MedGen:C0014544,Orphanet:ORPHA166463|MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C0424605|MedGen:CN239811|MedGen:CN239812	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5911	5911	C	G	MI.1896	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	8	3	A	G	gCc/gGc	-0.11	0	0	benign	0.05	deleterious	0	neutral	2.91	neutral	-1.75	neutral	-0.23	low_impact	1.25	0.67	neutral	0.64	neutral	1.98	16.10	deleterious	0.32	0.55	0.24	neutral	0.07	neutral	0.13	neutral	0.1	neutral	8	1	deleterious	0.48	deleterious	-2	neutral	0.09	neutral	0.45	medium_impact	-1.48	low_impact	0.06	medium_impact	0.73	0.9	11.5	19.25	0.64	P	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12018	12018	C	T	MI.18960	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1259	420	T	I	aCc/aTc	0.26	0	0	benign	0.32	neutral	0.37	neutral	2.22	deleterious	-3.17	deleterious	-3.59	medium_impact	2.68	0.72	neutral	0.53	neutral	2.40	18.84	deleterious	0.31	0.45	0.95	disease	0.5	neutral	0.45	neutral	0.81	disease	6	0.56	neutral	0.53	deleterious	-3	neutral	0.56	deleterious	-0.41	medium_impact	0.07	medium_impact	1.53	medium_impact	0.36	0.8	15.9	10.5	0.34	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12018	12018	C	A	MI.18961	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1259	420	T	N	aCc/aAc	0.26	0	0	benign	0.32	neutral	0.3	neutral	2.29	neutral	-0.2	neutral	-2.21	medium_impact	2.56	0.76	neutral	0.71	neutral	1.88	15.48	deleterious	0.64	0.7	0.84	disease	0.54	disease	0.26	neutral	0.59	disease	2	0.64	neutral	0.49	deleterious	-3	neutral	0.36	neutral	-0.41	medium_impact	0	medium_impact	1.41	medium_impact	0.55	0.8	15.9	10.5	0.37	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12020	12020	C	A	MI.18962	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1261	421	H	N	Cac/Aac	-14.47	0	0	benign	0.13	neutral	0.51	neutral	2.33	neutral	-0.01	neutral	-1.32	low_impact	1.09	0.7	neutral	0.95	neutral	1.98	16.10	deleterious	0.57	0.65	0.64	disease	0.21	neutral	0.3	neutral	0.49	neutral	0	0.4	neutral	0.69	deleterious	-6	neutral	0.64	deleterious	0.06	medium_impact	0.21	medium_impact	-0.05	medium_impact	0.31	0.8	22.44	19.28	0.41	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12020	12020	C	G	MI.18963	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1261	421	H	D	Cac/Gac	-14.47	0	0	benign	0.13	neutral	0.24	neutral	2.31	neutral	0.86	deleterious	-2.83	medium_impact	2.08	0.79	neutral	0.88	neutral	2.61	20.30	deleterious	0.32	0.5	0.78	disease	0.4	neutral	0.48	neutral	0.64	disease	3	0.72	neutral	0.56	deleterious	-3	neutral	0.71	deleterious	0.06	medium_impact	-0.08	medium_impact	0.93	medium_impact	0.38	0.8	22.44	19.28	0.37	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12020	12020	C	T	MI.18964	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1261	421	H	Y	Cac/Tac	-14.47	0	0	benign	0	neutral	1	neutral	2.28	neutral	-0.79	neutral	-0.69	low_impact	0.84	0.83	neutral	0.95	neutral	1.40	12.79	neutral	0.29	0.45	0.6	disease	0.32	neutral	0.33	neutral	0.59	disease	2	0	neutral	1	deleterious	-6	neutral	0.66	deleterious	2.1	high_impact	1.88	high_impact	-0.3	medium_impact	0.20	0.8	22.44	19.28	0.3	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12021	12021	A	G	MI.18965	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1262	421	H	R	cAc/cGc	-5.96	0	0	benign	0.18	neutral	0.37	neutral	2.31	neutral	-0.75	deleterious	-2.62	medium_impact	2.78	0.78	neutral	0.5	neutral	2.23	17.73	deleterious	0.36	0.5	0.67	disease	0.38	neutral	0.39	neutral	0.62	disease	2	0.56	neutral	0.6	deleterious	-3	neutral	0.70	deleterious	-0.1	medium_impact	0.07	medium_impact	1.62	medium_impact	0.18	0.8	22.44	19.28	0.33	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12021	12021	A	C	MI.18966	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1262	421	H	P	cAc/cCc	-5.96	0	0	benign	0	neutral	0.25	neutral	2.3	neutral	1.89	deleterious	-3.29	low_impact	0.95	0.77	neutral	0.79	neutral	2.32	18.31	deleterious	0.17	0.45	0.76	disease	0.57	disease	0.34	neutral	0.51	disease	0	0.75	neutral	0.63	deleterious	-6	neutral	0.77	deleterious	2.1	high_impact	-0.07	medium_impact	-0.19	medium_impact	0.27	0.8	22.44	19.28	0.33	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12021	12021	A	T	MI.18967	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1262	421	H	L	cAc/cTc	-5.96	0	0	benign	0.08	neutral	0.74	neutral	2.3	neutral	-0.22	deleterious	-3.75	low_impact	0.96	0.76	neutral	0.75	neutral	2.92	21.90	deleterious	0.29	0.45	0.52	disease	0.36	neutral	0.43	neutral	0.36	neutral	3	0.16	neutral	0.83	deleterious	-6	neutral	0.65	deleterious	0.28	medium_impact	0.46	medium_impact	-0.18	medium_impact	0.12	0.8	22.44	19.28	0.26	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12022	12022	C	A	MI.18968	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1263	421	H	Q	caC/caA	-0.66	0	0	benign	0.33	neutral	0.37	neutral	2.32	neutral	0.26	neutral	-2.1	low_impact	1.31	0.71	neutral	0.88	neutral	2.12	17.00	deleterious	0.45	0.55	0.69	disease	0.22	neutral	0.27	neutral	0.5	neutral	0	0.56	neutral	0.52	deleterious	-6	neutral	0.68	deleterious	-0.43	medium_impact	0.07	medium_impact	0.17	medium_impact	0.40	0.8	22.44	19.28	0.38	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12022	12022	C	G	MI.18969	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1263	421	H	Q	caC/caG	-0.66	0	0	benign	0.33	neutral	0.37	neutral	2.32	neutral	0.26	neutral	-2.1	low_impact	1.31	0.71	neutral	0.88	neutral	1.79	14.91	neutral	0.45	0.55	0.69	disease	0.22	neutral	0.27	neutral	0.5	neutral	0	0.56	neutral	0.52	deleterious	-6	neutral	0.68	deleterious	-0.43	medium_impact	0.07	medium_impact	0.17	medium_impact	0.40	0.8	22.44	19.28	0.38	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5913	5913	G	C	MI.1897	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	10	4	D	H	Gac/Cac	-5.89	0	0	benign	0.04	neutral	0.06	neutral	2.99	neutral	-1.17	neutral	0.02	neutral_impact	-1.15	0.72	neutral	0.64	neutral	1.78	14.89	neutral	0.46	0.55	0.36	neutral	0.11	neutral	0.28	neutral	0.28	neutral	4	0.94	neutral	0.51	deleterious	-6	neutral	0.14	neutral	0.54	medium_impact	-0.47	medium_impact	-2.16	low_impact	0.52	0.9	13.26	25.03	0.5	N	0.19	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12023	12023	C	A	MI.18970	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1264	422	H	N	Cac/Aac	-1.81	0	0	possibly_damaging	0.52	neutral	0.4	neutral	2.28	neutral	0.13	deleterious	-5.24	low_impact	1.27	0.75	neutral	0.27	damaging	4.06	23.70	deleterious	0.55	0.6	0.81	disease	0.62	disease	0.45	neutral	0.58	disease	1	0.59	neutral	0.44	neutral	-3	neutral	0.76	deleterious	-0.75	medium_impact	0.1	medium_impact	0.13	medium_impact	0.34	0.8	15.69	15.43	0.25	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12023	12023	C	G	MI.18971	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1264	422	H	D	Cac/Gac	-1.81	0	0	possibly_damaging	0.73	neutral	0.21	neutral	2.24	neutral	-0.36	deleterious	-7.13	low_impact	1.88	0.69	neutral	0.14	damaging	3.90	23.50	deleterious	0.27	0.45	0.88	disease	0.71	disease	0.67	disease	0.73	disease	5	0.84	neutral	0.24	neutral	-3	neutral	0.79	deleterious	-1.12	low_impact	-0.12	medium_impact	0.73	medium_impact	0.29	0.8	15.69	15.43	0.27	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12023	12023	C	T	MI.18972	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1264	422	H	Y	Cac/Tac	-1.81	0	0	possibly_damaging	0.88	neutral	0.93	neutral	2.21	neutral	-2.56	deleterious	-4.89	medium_impact	2.14	0.76	neutral	0.32	neutral	3.71	23.30	deleterious	0.31	0.45	0.73	disease	0.73	disease	0.47	neutral	0.57	disease	1	0.87	neutral	0.53	deleterious	0	NA	0.78	deleterious	-1.53	low_impact	0.83	medium_impact	0.99	medium_impact	0.35	0.8	15.69	15.43	0.2	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12024	12024	A	C	MI.18973	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1265	422	H	P	cAc/cCc	2.79	0.94	0	probably_damaging	0.92	neutral	0.15	neutral	2.22	deleterious	-3.27	deleterious	-8.11	medium_impact	2.78	0.65	neutral	0.15	damaging	3.29	22.80	deleterious	0.17	0.45	0.83	disease	0.85	disease	0.69	disease	0.73	disease	5	0.96	neutral	0.12	neutral	1	deleterious	0.86	deleterious	-1.71	low_impact	-0.22	medium_impact	1.62	medium_impact	0.29	0.8	15.69	15.43	0.43	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12024	12024	A	G	MI.18974	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1265	422	H	R	cAc/cGc	2.79	0.94	0	possibly_damaging	0.78	neutral	0.24	neutral	2.25	neutral	0.72	deleterious	-6.42	high_impact	3.58	0.66	neutral	0.12	damaging	3.07	22.50	deleterious	0.36	0.5	0.78	disease	0.76	disease	0.67	disease	0.68	disease	4	0.85	neutral	0.23	neutral	1	deleterious	0.80	deleterious	-1.23	low_impact	-0.08	medium_impact	2.42	high_impact	0.18	0.8	15.69	15.43	0.43	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12024	12024	A	T	MI.18975	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1265	422	H	L	cAc/cTc	2.79	0.94	0	possibly_damaging	0.78	neutral	0.5	neutral	2.21	neutral	-2.76	deleterious	-8.89	medium_impact	2.06	0.74	neutral	0.13	damaging	3.96	23.60	deleterious	0.28	0.45	0.7	disease	0.78	disease	0.7	disease	0.67	disease	3	0.76	neutral	0.36	neutral	0	NA	0.74	deleterious	-1.23	low_impact	0.2	medium_impact	0.91	medium_impact	0.15	0.8	15.69	15.43	0.39	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12025	12025	C	A	MI.18976	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1266	422	H	Q	caC/caA	4.4	0.96	0	possibly_damaging	0.85	neutral	0.2	neutral	2.26	neutral	-0.75	deleterious	-6.35	medium_impact	2.54	0.7	neutral	0.13	damaging	4.05	23.70	deleterious	0.45	0.55	0.8	disease	0.71	disease	0.61	disease	0.67	disease	3	0.91	neutral	0.18	neutral	0	NA	0.78	deleterious	-1.43	low_impact	-0.14	medium_impact	1.39	medium_impact	0.40	0.8	15.69	15.43	0.49	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12025	12025	C	G	MI.18977	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1266	422	H	Q	caC/caG	4.4	0.96	0	possibly_damaging	0.85	neutral	0.2	neutral	2.26	neutral	-0.75	deleterious	-6.35	medium_impact	2.54	0.7	neutral	0.13	damaging	3.65	23.20	deleterious	0.45	0.55	0.8	disease	0.71	disease	0.61	disease	0.67	disease	3	0.91	neutral	0.18	neutral	0	NA	0.78	deleterious	-1.43	low_impact	-0.14	medium_impact	1.39	medium_impact	0.40	0.8	15.69	15.43	0.49	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12026	12026	A	G	MI.18978	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1267	423	I	V	Att/Gtt	-1.81	0	0.04	benign	0	neutral	0.3	neutral	2.36	neutral	-1.59	neutral	-0.37	low_impact	1.75	0.77	neutral	0.96	neutral	-0.05	2.16	deleterious	0.62	0.65	0.45	neutral	0.18	neutral	0.4	neutral	0.34	neutral	3	0.7	neutral	0.65	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0	medium_impact	0.61	medium_impact	0.25	0.8	34.2	23.16	0.58	P	0.50	polymorphism	1	0.01	rs202136725	.	.	.	.	.	.	.	.	A12026G	DM	+	-	Reported	2	N	P	N,P	neutral
chrM	12026	12026	A	T	MI.18979	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1267	423	I	F	Att/Ttt	-1.81	0	0.04	benign	0.18	neutral	0.26	neutral	2.27	neutral	-2.42	neutral	-2.31	low_impact	1.62	0.7	neutral	0.51	neutral	1.83	15.14	deleterious	0.2	0.45	0.48	neutral	0.52	disease	0.23	neutral	0.47	neutral	1	0.69	neutral	0.54	deleterious	-6	neutral	0.28	neutral	-0.1	medium_impact	-0.05	medium_impact	0.48	medium_impact	0.26	0.8	34.2	23.16	0.41	N	0.43	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5913	5913	G	A	MI.1898	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	10	4	D	N	Gac/Aac	-5.89	0	0	benign	0	neutral	0.47	neutral	3.02	neutral	0.01	neutral	0.2	neutral_impact	-1.61	0.85	neutral	0.98	neutral	-0.59	0.14	neutral	0.73	0.75	0.15	neutral	0.04	neutral	0.13	neutral	0.22	neutral	6	0.53	neutral	0.74	deleterious	-6	neutral	0.05	neutral	2.07	high_impact	0.16	medium_impact	-2.59	low_impact	0.47	0.9	13.26	25.03	0.53	N	0.00	polymorphism	1	0.00	rs201617272	.	.	.	.	.	.	.	.	G5913A	Prostate Cancer / hypertension	+	-	Reported	3	N	P	N,P	neutral
chrM	12026	12026	A	C	MI.18980	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1267	423	I	L	Att/Ctt	-1.81	0	0.04	benign	0.01	neutral	0.87	neutral	2.35	neutral	-1.36	neutral	-0.49	neutral_impact	0.23	0.74	neutral	0.78	neutral	0.10	3.60	deleterious	0.43	0.55	0.38	neutral	0.13	neutral	0.14	neutral	0.26	neutral	5	0.1	neutral	0.93	deleterious	-6	neutral	0.10	neutral	1.16	medium_impact	0.67	medium_impact	-0.9	medium_impact	0.31	0.8	34.2	23.16	0.39	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12027	12027	T	C	MI.18981	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1268	423	I	T	aTt/aCt	0.95	0	0	benign	0	neutral	0.28	neutral	2.26	neutral	-1.31	neutral	-1.68	neutral_impact	0.04	0.83	neutral	0.97	neutral	0.14	3.99	deleterious	0.23	0.45	0.4	neutral	0.41	neutral	0.24	neutral	0.47	neutral	1	0.72	neutral	0.64	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	-0.03	medium_impact	-1.09	low_impact	0.12	0.8	34.2	23.16	0.47	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	T12027C	SZ-associated	.	.	Reported	2	.	P	P	neutral
chrM	12027	12027	T	G	MI.18982	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1268	423	I	S	aTt/aGt	0.95	0	0	benign	0.05	neutral	0.07	neutral	2.22	neutral	-0.7	deleterious	-2.84	low_impact	1.49	0.74	neutral	0.66	neutral	2.41	18.89	deleterious	0.14	0.4	0.72	disease	0.62	disease	0.3	neutral	0.53	disease	1	0.93	neutral	0.51	deleterious	-6	neutral	0.26	neutral	0.48	medium_impact	-0.43	medium_impact	0.35	medium_impact	0.12	0.8	34.2	23.16	0.41	N	0.46	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12027	12027	T	A	MI.18983	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1268	423	I	N	aTt/aAt	0.95	0	0	benign	0.14	neutral	0.21	neutral	2.18	neutral	-1.23	deleterious	-3.84	low_impact	1.14	0.8	neutral	0.59	neutral	2.61	20.30	deleterious	0.18	0.45	0.87	disease	0.67	disease	0.45	neutral	0.6	disease	2	0.76	neutral	0.54	deleterious	-6	neutral	0.43	neutral	0.02	medium_impact	-0.12	medium_impact	0	medium_impact	0.09	0.8	34.2	23.16	0.31	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12028	12028	T	A	MI.18984	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1269	423	I	M	atT/atA	0.95	0	0	benign	0.01	neutral	0.35	neutral	2.21	deleterious	-4.26	neutral	-0.87	neutral_impact	0.56	0.75	neutral	0.97	neutral	0.45	7.01	deleterious	0.47	0.55	0.46	neutral	0.17	neutral	0.17	neutral	0.3	neutral	4	0.64	neutral	0.67	deleterious	-6	neutral	0.39	neutral	1.16	medium_impact	0.05	medium_impact	-0.57	medium_impact	0.34	0.8	34.2	23.16	0.57	P	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12028	12028	T	G	MI.18985	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1269	423	I	M	atT/atG	0.95	0	0	benign	0.01	neutral	0.35	neutral	2.21	deleterious	-4.26	neutral	-0.87	neutral_impact	0.56	0.75	neutral	0.97	neutral	0.21	4.77	deleterious	0.47	0.55	0.46	neutral	0.17	neutral	0.17	neutral	0.3	neutral	4	0.64	neutral	0.67	deleterious	-6	neutral	0.39	neutral	1.16	medium_impact	0.05	medium_impact	-0.57	medium_impact	0.34	0.8	34.2	23.16	0.57	P	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12029	12029	A	G	MI.18986	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1270	424	N	D	Aac/Gac	-8.49	0	0	benign	0.01	neutral	0.18	neutral	2.25	neutral	-1.96	neutral	-1.81	medium_impact	2.26	0.78	neutral	0.48	neutral	0.70	8.82	deleterious	0.75	0.8	0.62	disease	0.29	neutral	0.35	neutral	0.55	disease	1	0.82	neutral	0.59	deleterious	-3	neutral	0.15	neutral	1.16	medium_impact	-0.17	medium_impact	1.11	medium_impact	0.34	0.8	32.9	28.3	0.4	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12029	12029	A	T	MI.18987	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1270	424	N	Y	Aac/Tac	-8.49	0	0	benign	0	neutral	1	neutral	2.19	neutral	-1.09	neutral	-1.29	low_impact	0.82	0.79	neutral	0.75	neutral	-0.83	0.04	neutral	0.21	0.45	0.83	disease	0.31	neutral	0.17	neutral	0.62	disease	2	0	neutral	1	deleterious	-6	neutral	0.24	neutral	2.1	high_impact	1.88	high_impact	-0.32	medium_impact	0.27	0.8	32.9	28.3	0.31	N	0.85	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12029	12029	A	C	MI.18988	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1270	424	N	H	Aac/Cac	-8.49	0	0	benign	0.04	neutral	0.49	neutral	2.21	deleterious	-3.45	neutral	-0.58	low_impact	1.06	0.78	neutral	0.91	neutral	-0.65	0.10	neutral	0.58	0.65	0.76	disease	0.24	neutral	0.2	neutral	0.57	disease	1	0.47	neutral	0.73	deleterious	-6	neutral	0.22	neutral	0.58	medium_impact	0.19	medium_impact	-0.08	medium_impact	0.20	0.8	32.9	28.3	0.37	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12030	12030	A	C	MI.18989	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1271	424	N	T	aAc/aCc	0.49	0	0	benign	0	neutral	0.43	neutral	2.26	neutral	-1.57	neutral	-1.12	neutral_impact	-0.5	0.7	neutral	0.92	neutral	-0.16	1.33	neutral	0.53	0.6	0.39	neutral	0.16	neutral	0.15	neutral	0.29	neutral	4	0.57	neutral	0.72	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	0.13	medium_impact	-1.62	low_impact	0.28	0.8	32.9	28.3	0.52	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5913	5913	G	T	MI.1899	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	10	4	D	Y	Gac/Tac	-5.89	0	0	benign	0	neutral	0.06	neutral	3.03	neutral	-1.83	neutral	-0.05	neutral_impact	-0.98	0.69	neutral	0.65	neutral	2.16	17.27	deleterious	0.37	0.55	0.45	neutral	0.25	neutral	0.54	disease	0.45	neutral	1	0.94	neutral	0.53	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	-0.47	medium_impact	-2	low_impact	0.27	0.9	13.26	25.03	0.46	N	0.66	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12030	12030	A	T	MI.18990	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1271	424	N	I	aAc/aTc	0.49	0	0	benign	0	neutral	0.42	neutral	2.2	neutral	-0.72	neutral	-1.54	neutral_impact	-0.38	0.71	neutral	0.97	neutral	0.27	5.37	deleterious	0.26	0.45	0.75	disease	0.25	neutral	0.18	neutral	0.58	disease	2	0.58	neutral	0.71	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	0.12	medium_impact	-1.5	low_impact	0.33	0.8	32.9	28.3	0.47	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12030	12030	A	G	MI.18991	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1271	424	N	S	aAc/aGc	0.49	0	0	benign	0	neutral	0.44	neutral	2.28	neutral	-0.13	neutral	-0.9	neutral_impact	0.16	0.73	neutral	0.87	neutral	-0.44	0.31	neutral	0.77	0.8	0.37	neutral	0.17	neutral	0.19	neutral	0.3	neutral	4	0.56	neutral	0.72	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.14	medium_impact	-0.97	medium_impact	0.29	0.8	32.9	28.3	0.51	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12031	12031	C	G	MI.18992	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1272	424	N	K	aaC/aaG	-1.58	0	0	benign	0	neutral	0.3	neutral	2.33	neutral	-0.96	neutral	-0.95	neutral_impact	-0.14	0.83	neutral	0.97	neutral	0.57	7.93	deleterious	0.65	0.7	0.45	neutral	0.17	neutral	0.21	neutral	0.3	neutral	4	0.7	neutral	0.65	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	0	medium_impact	-1.26	low_impact	0.47	0.8	32.9	28.3	0.47	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12031	12031	C	A	MI.18993	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1272	424	N	K	aaC/aaA	-1.58	0	0	benign	0	neutral	0.3	neutral	2.33	neutral	-0.96	neutral	-0.95	neutral_impact	-0.14	0.83	neutral	0.97	neutral	1.05	10.95	neutral	0.65	0.7	0.45	neutral	0.17	neutral	0.21	neutral	0.3	neutral	4	0.7	neutral	0.65	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	0	medium_impact	-1.26	low_impact	0.47	0.8	32.9	28.3	0.47	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12032	12032	A	T	MI.18994	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1273	425	N	Y	Aac/Tac	-6.19	0	0	probably_damaging	0.94	neutral	1	neutral	2.14	deleterious	-5.18	deleterious	-3.25	medium_impact	1.96	0.84	neutral	0.61	neutral	2.32	18.28	deleterious	0.19	0.45	0.9	disease	0.49	neutral	0.36	neutral	0.64	disease	3	0.94	neutral	0.53	deleterious	1	deleterious	0.75	deleterious	-1.84	low_impact	1.88	high_impact	0.81	medium_impact	0.27	0.8	21.57	18.65	0.2	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12032	12032	A	C	MI.18995	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1273	425	N	H	Aac/Cac	-6.19	0	0	probably_damaging	0.92	neutral	0.52	neutral	2.17	deleterious	-3.48	neutral	-2.22	low_impact	1.76	0.82	neutral	0.74	neutral	1.91	15.66	deleterious	0.58	0.65	0.87	disease	0.34	neutral	0.25	neutral	0.65	disease	3	0.91	neutral	0.3	neutral	-2	neutral	0.70	deleterious	-1.71	low_impact	0.22	medium_impact	0.62	medium_impact	0.18	0.8	21.57	18.65	0.31	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12032	12032	A	G	MI.18996	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1273	425	N	D	Aac/Gac	-6.19	0	0	benign	0.42	neutral	0.22	neutral	2.2	neutral	-1.35	neutral	-1.96	medium_impact	2.6	0.8	neutral	0.63	neutral	2.70	20.80	deleterious	0.75	0.8	0.8	disease	0.34	neutral	0.37	neutral	0.65	disease	3	0.75	neutral	0.4	neutral	-3	neutral	0.70	deleterious	-0.59	medium_impact	-0.11	medium_impact	1.45	medium_impact	0.42	0.8	21.57	18.65	0.39	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12033	12033	A	T	MI.18997	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1274	425	N	I	aAc/aTc	-0.66	0	0	possibly_damaging	0.84	neutral	0.47	neutral	2.15	deleterious	-4.88	deleterious	-3.49	low_impact	1.66	0.78	neutral	0.91	neutral	2.97	22.10	deleterious	0.24	0.45	0.67	disease	0.5	neutral	0.22	neutral	0.45	neutral	1	0.83	neutral	0.32	neutral	-3	neutral	0.71	deleterious	-1.39	low_impact	0.17	medium_impact	0.52	medium_impact	0.23	0.8	21.57	18.65	0.34	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12033	12033	A	G	MI.18998	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1274	425	N	S	aAc/aGc	-0.66	0	0	benign	0.06	neutral	0.8	neutral	2.26	neutral	-1.92	neutral	-0.61	low_impact	0.88	0.74	neutral	1	neutral	1.21	11.80	neutral	0.73	0.75	0.44	neutral	0.1	neutral	0.18	neutral	0.28	neutral	4	0.11	neutral	0.87	deleterious	-6	neutral	0.61	deleterious	0.41	medium_impact	0.54	medium_impact	-0.26	medium_impact	0.33	0.8	21.57	18.65	0.44	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	A12033G	LHON synergistic combo 10680A + 12033G + 14258A	+	-	Reported: individually neutral variants causing LHON in combination	1	.	.	.	neutral
chrM	12033	12033	A	C	MI.18999	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1274	425	N	T	aAc/aCc	-0.66	0	0	benign	0.42	neutral	0.5	neutral	2.22	neutral	-1.58	neutral	-1.54	low_impact	1.12	0.71	neutral	0.93	neutral	2.09	16.80	deleterious	0.53	0.6	0.56	disease	0.25	neutral	0.17	neutral	0.55	disease	1	0.45	neutral	0.54	deleterious	-6	neutral	0.64	deleterious	-0.59	medium_impact	0.2	medium_impact	-0.02	medium_impact	0.28	0.8	21.57	18.65	0.42	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8534	8534	A	T	MI.19	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	8	3	E	V	gAa/gTa	-0.1	0.06	0	probably_damaging	0.98	neutral	0.59	neutral	4.68	neutral	-0.07	neutral	-2.36	neutral_impact	0.64	0.8	neutral	0.66	neutral	8.43	35.00	deleterious	0.43	0.65	0.59	disease	0.17	neutral	0.15	neutral	0.39	neutral	2	0.98	neutral	0.31	neutral	-2	neutral	0.66	deleterious	-2.36	low_impact	0.38	medium_impact	-0.55	medium_impact	0.81	0.9	15.93	14.48	0.29	N	0.85	polymorphism	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8616	8616	G	T	MI.190	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	90	30	L	F	ttG/ttT	7.53	0.96	0.02	probably_damaging	1	neutral	0.39	neutral	4.31	neutral	-0.71	deleterious	-3.18	low_impact	1.63	0.91	neutral	0.87	neutral	2.33	18.35	deleterious	0.41	0.65	0.66	disease	0.4	neutral	0.15	neutral	0.62	disease	2	1	deleterious	0.2	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.18	medium_impact	0.3	medium_impact	0.59	0.9	17.7	14.1	0.5	N	0.87	polymorphism	1	0.05	rs41427749	Likely_benign	not_provided	237307	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5914	5914	A	C	MI.1900	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	11	4	D	A	gAc/gCc	2.9	0.03	0	benign	0	neutral	0.15	neutral	3.05	neutral	0.42	neutral	0.04	neutral_impact	-1.36	0.71	neutral	0.72	neutral	2.10	16.88	deleterious	0.42	0.55	0.19	neutral	0.11	neutral	0.37	neutral	0.26	neutral	5	0.85	neutral	0.58	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	-0.23	medium_impact	-2.36	low_impact	0.38	0.9	13.26	25.03	0.53	N	0.41	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12034	12034	C	A	MI.19000	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1275	425	N	K	aaC/aaA	0.03	0	0	possibly_damaging	0.56	neutral	0.38	neutral	2.26	neutral	-0.78	neutral	-2.19	medium_impact	1.96	0.79	neutral	0.67	neutral	3.40	23.00	deleterious	0.65	0.7	0.71	disease	0.4	neutral	0.39	neutral	0.64	disease	3	0.63	neutral	0.41	neutral	0	NA	0.71	deleterious	-0.82	medium_impact	0.08	medium_impact	0.81	medium_impact	0.42	0.8	21.57	18.65	0.34	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12034	12034	C	G	MI.19001	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1275	425	N	K	aaC/aaG	0.03	0	0	possibly_damaging	0.56	neutral	0.38	neutral	2.26	neutral	-0.78	neutral	-2.19	medium_impact	1.96	0.79	neutral	0.67	neutral	2.88	21.80	deleterious	0.65	0.7	0.71	disease	0.4	neutral	0.39	neutral	0.64	disease	3	0.63	neutral	0.41	neutral	0	NA	0.71	deleterious	-0.82	medium_impact	0.08	medium_impact	0.81	medium_impact	0.42	0.8	21.57	18.65	0.34	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12035	12035	A	G	MI.19002	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1276	426	M	V	Ata/Gta	-9.87	0	0	benign	0	neutral	0.41	neutral	2.38	neutral	4.22	neutral	0.3	low_impact	1.46	0.78	neutral	0.96	neutral	1.28	12.17	neutral	0.44	0.55	0.55	disease	0.22	neutral	0.27	neutral	0.47	neutral	1	0.59	neutral	0.71	deleterious	-6	neutral	0.41	neutral	2.1	high_impact	0.11	medium_impact	0.32	medium_impact	0.28	0.8	28.98	29.5	0.43	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12035	12035	A	T	MI.19003	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1276	426	M	L	Ata/Tta	-9.87	0	0	benign	0	neutral	1	neutral	2.45	neutral	2.86	neutral	0.46	low_impact	0.8	0.68	neutral	0.97	neutral	0.25	5.15	deleterious	0.33	0.5	0.68	disease	0.09	neutral	0.19	neutral	0.36	neutral	3	0	neutral	1	deleterious	-6	neutral	0.35	neutral	2.1	high_impact	1.88	high_impact	-0.33	medium_impact	0.21	0.8	28.98	29.5	0.44	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12035	12035	A	C	MI.19004	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1276	426	M	L	Ata/Cta	-9.87	0	0	benign	0	neutral	1	neutral	2.45	neutral	2.86	neutral	0.46	low_impact	0.8	0.68	neutral	0.97	neutral	0.17	4.35	deleterious	0.33	0.5	0.68	disease	0.09	neutral	0.19	neutral	0.36	neutral	3	0	neutral	1	deleterious	-6	neutral	0.35	neutral	2.1	high_impact	1.88	high_impact	-0.33	medium_impact	0.21	0.8	28.98	29.5	0.45	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12036	12036	T	A	MI.19005	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1277	426	M	K	aTa/aAa	-0.43	0	0	benign	0.29	neutral	0.15	neutral	2.29	neutral	2.42	deleterious	-3.65	medium_impact	3.08	0.73	neutral	0.52	neutral	4.03	23.60	deleterious	0.15	0.4	0.75	disease	0.49	neutral	0.51	disease	0.58	disease	2	0.82	neutral	0.43	neutral	-3	neutral	0.68	deleterious	-0.35	medium_impact	-0.22	medium_impact	1.92	medium_impact	0.28	0.8	28.98	29.5	0.42	N	0.89	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12036	12036	T	C	MI.19006	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1277	426	M	T	aTa/aCa	-0.43	0	0	benign	0.12	neutral	0.3	neutral	2.33	neutral	2.76	neutral	-2.23	low_impact	0.92	0.67	neutral	0.84	neutral	1.90	15.60	deleterious	0.22	0.45	0.46	neutral	0.28	neutral	0.28	neutral	0.45	neutral	1	0.66	neutral	0.59	deleterious	-6	neutral	0.59	deleterious	0.1	medium_impact	0	medium_impact	-0.22	medium_impact	0.09	0.8	28.98	29.5	0.44	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12037	12037	A	C	MI.19007	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1278	426	M	I	atA/atC	3.71	0.33	0	benign	0	neutral	0.63	neutral	2.37	neutral	4.61	neutral	0.85	neutral_impact	0.43	0.77	neutral	0.98	neutral	0.98	10.57	neutral	0.35	0.5	0.51	disease	0.09	neutral	0.18	neutral	0.27	neutral	5	0.37	neutral	0.82	deleterious	-6	neutral	0.48	deleterious	2.1	high_impact	0.33	medium_impact	-0.7	medium_impact	0.26	0.8	28.98	29.5	0.48	N	0.13	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12037	12037	A	T	MI.19008	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1278	426	M	I	atA/atT	3.71	0.33	0	benign	0	neutral	0.63	neutral	2.37	neutral	4.61	neutral	0.85	neutral_impact	0.43	0.77	neutral	0.98	neutral	1.06	10.99	neutral	0.35	0.5	0.51	disease	0.09	neutral	0.18	neutral	0.27	neutral	5	0.37	neutral	0.82	deleterious	-6	neutral	0.48	deleterious	2.1	high_impact	0.33	medium_impact	-0.7	medium_impact	0.26	0.8	28.98	29.5	0.49	N	0.13	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12038	12038	A	C	MI.19009	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1279	427	K	Q	Aaa/Caa	-8.95	0	0	possibly_damaging	0.8	neutral	0.71	neutral	2.21	neutral	-1.02	neutral	-0.64	low_impact	0.87	0.72	neutral	0.96	neutral	1.82	15.09	deleterious	0.46	0.55	0.65	disease	0.17	neutral	0.14	neutral	0.4	neutral	2	0.76	neutral	0.46	neutral	-3	neutral	0.67	deleterious	-1.28	low_impact	0.42	medium_impact	-0.27	medium_impact	0.24	0.8	22.44	24.22	0.37	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5914	5914	A	T	MI.1901	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	11	4	D	V	gAc/gTc	2.9	0.03	0	benign	0.02	neutral	0.06	neutral	3.07	neutral	-0.63	neutral	0.04	neutral_impact	-2	0.71	neutral	0.68	neutral	1.33	12.41	neutral	0.38	0.55	0.24	neutral	0.16	neutral	0.42	neutral	0.29	neutral	4	0.94	neutral	0.52	deleterious	-6	neutral	0.10	neutral	0.83	medium_impact	-0.47	medium_impact	-2.95	low_impact	0.28	0.9	13.26	25.03	0.5	N	0.71	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12038	12038	A	G	MI.19010	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1279	427	K	E	Aaa/Gaa	-8.95	0	0	benign	0.42	neutral	0.97	neutral	2.25	neutral	-0.79	neutral	-0.75	low_impact	1.2	0.75	neutral	0.73	neutral	2.12	16.97	deleterious	0.23	0.45	0.71	disease	0.31	neutral	0.18	neutral	0.63	disease	3	0.39	neutral	0.78	deleterious	-6	neutral	0.72	deleterious	-0.59	medium_impact	1.05	medium_impact	0.06	medium_impact	0.42	0.8	22.44	24.22	0.34	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12039	12039	A	T	MI.19011	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1280	427	K	M	aAa/aTa	-0.89	0	0	probably_damaging	0.94	neutral	0.2	neutral	2.12	deleterious	-4.46	neutral	-1.98	medium_impact	1.97	0.82	neutral	0.67	neutral	3.90	23.50	deleterious	0.18	0.45	0.39	neutral	0.17	neutral	0.32	neutral	0.33	neutral	4	0.96	neutral	0.13	neutral	1	deleterious	0.65	deleterious	-1.84	low_impact	-0.14	medium_impact	0.82	medium_impact	0.17	0.8	22.44	24.22	0.45	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12039	12039	A	C	MI.19012	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1280	427	K	T	aAa/aCa	-0.89	0	0	possibly_damaging	0.56	neutral	0.68	neutral	2.19	neutral	-0.9	neutral	-0.96	low_impact	0.82	0.72	neutral	0.98	neutral	1.89	15.50	deleterious	0.27	0.45	0.38	neutral	0.18	neutral	0.15	neutral	0.3	neutral	4	0.48	neutral	0.56	deleterious	-3	neutral	0.64	deleterious	-0.82	medium_impact	0.39	medium_impact	-0.32	medium_impact	0.12	0.8	22.44	24.22	0.44	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12040	12040	A	C	MI.19013	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1281	427	K	N	aaA/aaC	-0.43	0	0	benign	0.03	neutral	0.7	neutral	2.2	neutral	-1.78	neutral	-0.52	low_impact	1.07	0.71	neutral	0.97	neutral	2.19	17.47	deleterious	0.61	0.65	0.69	disease	0.15	neutral	0.15	neutral	0.4	neutral	2	0.24	neutral	0.84	deleterious	-6	neutral	0.70	deleterious	0.7	medium_impact	0.41	medium_impact	-0.07	medium_impact	0.37	0.8	22.44	24.22	0.41	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12040	12040	A	T	MI.19014	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1281	427	K	N	aaA/aaT	-0.43	0	0	benign	0.03	neutral	0.7	neutral	2.2	neutral	-1.78	neutral	-0.52	low_impact	1.07	0.71	neutral	0.97	neutral	2.27	17.95	deleterious	0.61	0.65	0.69	disease	0.15	neutral	0.15	neutral	0.4	neutral	2	0.24	neutral	0.84	deleterious	-6	neutral	0.70	deleterious	0.7	medium_impact	0.41	medium_impact	-0.07	medium_impact	0.37	0.8	22.44	24.22	0.41	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12041	12041	C	G	MI.19015	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1282	428	P	A	Ccc/Gcc	-5.04	0	0	probably_damaging	1	neutral	0.41	neutral	2.23	neutral	-2.87	deleterious	-7.12	medium_impact	3.25	0.76	neutral	0.57	neutral	3.22	22.70	deleterious	0.49	0.55	0.74	disease	0.54	disease	0.63	disease	0.57	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.11	medium_impact	2.09	high_impact	0.40	0.8	47.71	9.38	0.32	N	0.74	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12041	12041	C	T	MI.19016	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1282	428	P	S	Ccc/Tcc	-5.04	0	0	probably_damaging	1	neutral	0.56	neutral	2.25	neutral	-0.29	deleterious	-7.09	medium_impact	2.84	0.76	neutral	0.57	neutral	3.97	23.60	deleterious	0.46	0.55	0.42	neutral	0.66	disease	0.61	disease	0.48	neutral	1	1	deleterious	0.28	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	0.26	medium_impact	1.68	medium_impact	0.11	0.8	47.71	9.38	0.26	N	0.68	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12041	12041	C	A	MI.19017	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1282	428	P	T	Ccc/Acc	-5.04	0	0	probably_damaging	1	neutral	0.38	neutral	2.22	neutral	-2.2	deleterious	-7.13	high_impact	3.6	0.69	neutral	0.52	neutral	3.99	23.60	deleterious	0.33	0.5	0.41	neutral	0.76	disease	0.51	disease	0.56	disease	1	1	deleterious	0.19	neutral	2	deleterious	0.73	deleterious	-3.54	low_impact	0.08	medium_impact	2.44	high_impact	0.33	0.8	47.71	9.38	0.37	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12042	12042	C	T	MI.19018	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1283	428	P	L	cCc/cTc	4.4	0.98	0	probably_damaging	1	neutral	0.61	neutral	2.19	neutral	-0.67	deleterious	-8.95	medium_impact	3.06	0.7	neutral	0.46	neutral	4.49	24.30	deleterious	0.24	0.45	0.42	neutral	0.76	disease	0.44	neutral	0.52	disease	0	1	deleterious	0.31	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	0.31	medium_impact	1.9	medium_impact	0.51	0.8	47.71	9.38	0.48	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12042	12042	C	A	MI.19019	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1283	428	P	H	cCc/cAc	4.4	0.98	0	probably_damaging	1	neutral	0.36	neutral	2.17	deleterious	-4.83	deleterious	-8.03	high_impact	4.16	0.71	neutral	0.39	neutral	4.33	24.00	deleterious	0.3	0.45	0.81	disease	0.8	disease	0.69	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.79	deleterious	-3.54	low_impact	0.06	medium_impact	2.99	high_impact	0.18	0.8	47.71	9.38	0.63	P	0.70	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5914	5914	A	G	MI.1902	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	11	4	D	G	gAc/gGc	2.9	0.03	0	benign	0.01	neutral	0.05	neutral	2.99	neutral	-0.89	neutral	-0.08	neutral_impact	-0.98	0.68	neutral	0.57	neutral	2.53	19.65	deleterious	0.43	0.55	0.32	neutral	0.15	neutral	0.4	neutral	0.28	neutral	4	0.95	neutral	0.52	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	-0.52	medium_impact	-2	low_impact	0.41	0.9	13.26	25.03	0.53	N	0.23	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12042	12042	C	G	MI.19020	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1283	428	P	R	cCc/cGc	4.4	0.98	0	probably_damaging	1	neutral	0.25	neutral	2.23	deleterious	-4.05	deleterious	-8.04	high_impact	4.16	0.63	neutral	0.45	neutral	3.77	23.40	deleterious	0.17	0.45	0.75	disease	0.83	disease	0.69	disease	0.73	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.07	medium_impact	2.99	high_impact	0.21	0.8	47.71	9.38	0.63	P	0.62	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12044	12044	T	A	MI.19021	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1285	429	S	T	Tca/Aca	-10.56	0	0	benign	0.28	neutral	0.42	neutral	2.26	neutral	-0.97	neutral	-0.72	neutral_impact	0.51	0.77	neutral	0.99	neutral	2.19	17.48	deleterious	0.57	0.65	0.5	neutral	0.17	neutral	0.19	neutral	0.24	neutral	5	0.49	neutral	0.57	deleterious	-6	neutral	0.63	deleterious	-0.33	medium_impact	0.12	medium_impact	-0.62	medium_impact	0.38	0.8	23.75	18.84	0.49	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12044	12044	T	G	MI.19022	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1285	429	S	A	Tca/Gca	-10.56	0	0	benign	0.17	neutral	0.5	neutral	2.28	neutral	-1.73	neutral	-1.84	low_impact	1.49	0.78	neutral	0.7	neutral	3.76	23.30	deleterious	0.56	0.6	0.44	neutral	0.33	neutral	0.46	neutral	0.48	neutral	1	0.4	neutral	0.67	deleterious	-6	neutral	0.62	deleterious	-0.07	medium_impact	0.2	medium_impact	0.35	medium_impact	0.20	0.8	23.75	18.84	0.35	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12044	12044	T	C	MI.19023	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1285	429	S	P	Tca/Cca	-10.56	0	0	benign	0	neutral	0.2	neutral	2.19	neutral	-0.26	deleterious	-3.33	neutral_impact	0.77	0.75	neutral	0.64	neutral	4.02	23.60	deleterious	0.19	0.45	0.67	disease	0.76	disease	0.27	neutral	0.53	disease	1	0.8	neutral	0.6	deleterious	-6	neutral	0.78	deleterious	2.1	high_impact	-0.14	medium_impact	-0.36	medium_impact	0.12	0.8	23.75	18.84	0.37	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12045	12045	C	G	MI.19024	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1286	429	S	W	tCa/tGa	-1.35	0	0	possibly_damaging	0.88	neutral	0.18	neutral	2.15	deleterious	-6.67	deleterious	-4.36	medium_impact	2.75	0.76	neutral	0.4	neutral	4.50	24.30	deleterious	0.08	0.35	0.79	disease	0.77	disease	0.67	disease	0.76	disease	5	0.93	neutral	0.15	neutral	0	NA	0.77	deleterious	-1.53	low_impact	-0.17	medium_impact	1.6	medium_impact	0.06	0.8	23.75	18.84	0.31	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12045	12045	C	T	MI.19025	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1286	429	S	L	tCa/tTa	-1.35	0	0	benign	0.01	neutral	0.7	neutral	2.25	deleterious	-3.57	deleterious	-3.38	low_impact	1.85	0.78	neutral	0.57	neutral	4.71	24.60	deleterious	0.24	0.45	0.7	disease	0.63	disease	0.46	neutral	0.53	disease	1	0.28	neutral	0.85	deleterious	-6	neutral	0.68	deleterious	1.16	medium_impact	0.41	medium_impact	0.7	medium_impact	0.32	0.8	23.75	18.84	0.23	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12047	12047	T	C	MI.19026	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1288	430	F	L	Ttc/Ctc	-12.4	0	0	benign	0.01	neutral	0.59	neutral	2.37	neutral	-1.27	deleterious	-3.88	low_impact	1.33	0.75	neutral	0.77	neutral	1.04	10.91	neutral	0.22	0.45	NA	NA	0.53	disease	0.46	neutral	0.46	neutral	1	0.4	neutral	0.79	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.29	medium_impact	0.19	medium_impact	0.64	0.8	23.31	21.92	0.33	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12047	12047	T	A	MI.19027	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1288	430	F	I	Ttc/Atc	-12.4	0	0	benign	0.1	neutral	0.38	neutral	2.33	deleterious	-3.01	deleterious	-3.93	medium_impact	2.65	0.74	neutral	0.54	neutral	2.58	20.00	deleterious	0.24	0.45	NA	NA	0.7	disease	0.47	neutral	0.49	neutral	0	0.56	neutral	0.64	deleterious	-3	neutral	0.17	neutral	0.18	medium_impact	0.08	medium_impact	1.5	medium_impact	0.46	0.8	23.31	21.92	0.41	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12047	12047	T	G	MI.19028	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1288	430	F	V	Ttc/Gtc	-12.4	0	0	benign	0.16	neutral	0.55	neutral	2.34	neutral	-2.6	deleterious	-4.44	medium_impact	2.3	0.75	neutral	0.54	neutral	2.26	17.91	deleterious	0.24	0.45	NA	NA	0.7	disease	0.49	neutral	0.51	disease	0	0.34	neutral	0.7	deleterious	-3	neutral	0.16	neutral	-0.04	medium_impact	0.25	medium_impact	1.15	medium_impact	0.50	0.8	23.31	21.92	0.29	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12048	12048	T	G	MI.19029	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1289	430	F	C	tTc/tGc	0.72	0	0	possibly_damaging	0.74	neutral	0.15	neutral	2.25	deleterious	-5.08	deleterious	-5.1	medium_impact	3	0.72	neutral	0.42	neutral	2.42	18.98	deleterious	0.1	0.4	NA	NA	0.77	disease	0.62	disease	0.75	disease	5	0.89	neutral	0.21	neutral	0	NA	0.38	neutral	-1.14	low_impact	-0.22	medium_impact	1.84	medium_impact	0.35	0.8	23.31	21.92	0.37	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5915	5915	C	G	MI.1903	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	12	4	D	E	gaC/gaG	1.05	0.02	0	benign	0.02	neutral	0.12	neutral	3.03	neutral	0.83	neutral	0.04	neutral_impact	-1.75	0.74	neutral	0.68	neutral	0.65	8.51	deleterious	0.54	0.6	0.15	neutral	0.09	neutral	0.12	neutral	0.27	neutral	5	0.88	neutral	0.55	deleterious	-6	neutral	0.07	neutral	0.83	medium_impact	-0.29	medium_impact	-2.72	low_impact	0.33	0.9	13.26	25.03	0.58	P	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12048	12048	T	C	MI.19030	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1289	430	F	S	tTc/tCc	0.72	0	0	benign	0.02	neutral	0.48	neutral	2.35	neutral	-0.54	deleterious	-4.54	low_impact	1.8	0.73	neutral	0.77	neutral	1.38	12.70	neutral	0.16	0.45	NA	NA	0.61	disease	0.41	neutral	0.46	neutral	1	0.5	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.87	medium_impact	0.18	medium_impact	0.66	medium_impact	0.33	0.8	23.31	21.92	0.37	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12048	12048	T	A	MI.19031	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1289	430	F	Y	tTc/tAc	0.72	0	0	benign	0.16	neutral	1	neutral	2.28	deleterious	-3.97	neutral	-0.3	low_impact	1.36	0.72	neutral	0.97	neutral	1.08	11.10	neutral	0.23	0.45	NA	NA	0.43	neutral	0.28	neutral	0.21	neutral	6	0.16	neutral	0.92	deleterious	-6	neutral	0.19	neutral	-0.04	medium_impact	1.88	high_impact	0.22	medium_impact	0.31	0.8	23.31	21.92	0.34	N	0.68	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12049	12049	C	G	MI.19032	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1290	430	F	L	ttC/ttG	0.26	0	0	benign	0.01	neutral	0.59	neutral	2.37	neutral	-1.27	deleterious	-3.88	low_impact	1.33	0.75	neutral	0.77	neutral	1.30	12.28	neutral	0.22	0.45	NA	NA	0.53	disease	0.46	neutral	0.46	neutral	1	0.4	neutral	0.79	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.29	medium_impact	0.19	medium_impact	0.64	0.8	23.31	21.92	0.3	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12049	12049	C	A	MI.19033	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1290	430	F	L	ttC/ttA	0.26	0	0	benign	0.01	neutral	0.59	neutral	2.37	neutral	-1.27	deleterious	-3.88	low_impact	1.33	0.75	neutral	0.77	neutral	1.59	13.79	neutral	0.22	0.45	NA	NA	0.53	disease	0.46	neutral	0.46	neutral	1	0.4	neutral	0.79	deleterious	-6	neutral	0.13	neutral	1.16	medium_impact	0.29	medium_impact	0.19	medium_impact	0.64	0.8	23.31	21.92	0.31	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12050	12050	A	T	MI.19034	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1291	431	T	S	Aca/Tca	-2.73	0	0	probably_damaging	1	neutral	0.82	neutral	2.29	neutral	0.7	deleterious	-3.5	medium_impact	2	0.58	damaging	0.27	damaging	2.24	17.78	deleterious	0.44	0.55	0.83	disease	0.26	neutral	0.31	neutral	0.57	disease	1	0.99	deleterious	0.41	neutral	1	deleterious	0.71	deleterious	-3.54	low_impact	0.57	medium_impact	0.85	medium_impact	0.54	0.8	46.84	9.2	0.26	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12050	12050	A	G	MI.19035	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1291	431	T	A	Aca/Gca	-2.73	0	0	probably_damaging	1	neutral	0.1	neutral	2.27	neutral	-1.67	deleterious	-4.44	high_impact	3.52	0.47	damaging	0.14	damaging	3.60	23.20	deleterious	0.25	0.45	0.5	neutral	0.47	neutral	0.65	disease	0.46	neutral	1	1	deleterious	0.05	neutral	2	deleterious	0.68	deleterious	-3.54	low_impact	-0.33	medium_impact	2.36	high_impact	0.33	0.8	46.84	9.2	0.42	N	0.68	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12050	12050	A	C	MI.19036	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1291	431	T	P	Aca/Cca	-2.73	0	0	probably_damaging	1	neutral	0.06	neutral	2.21	deleterious	-3.39	deleterious	-5.36	high_impact	3.52	0.36	damaging	0.08	damaging	3.65	23.20	deleterious	0.1	0.4	0.91	disease	0.75	disease	0.64	disease	0.76	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.47	medium_impact	2.36	high_impact	0.30	0.8	46.84	9.2	0.49	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12051	12051	C	T	MI.19037	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1292	431	T	M	aCa/aTa	5.32	1	0	probably_damaging	1	neutral	0.13	neutral	2.19	deleterious	-3.96	deleterious	-5.36	medium_impact	3.27	0.43	damaging	0.08	damaging	4.20	23.90	deleterious	0.17	0.45	0.75	disease	0.6	disease	0.69	disease	0.61	disease	2	1	deleterious	0.07	neutral	1	deleterious	0.73	deleterious	-3.54	low_impact	-0.26	medium_impact	2.11	high_impact	0.42	0.8	46.84	9.2	0.69	P	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12051	12051	C	A	MI.19038	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1292	431	T	K	aCa/aAa	5.32	1	0	probably_damaging	1	neutral	0.06	neutral	2.26	neutral	-1.22	deleterious	-5.35	high_impact	3.73	0.44	damaging	0.07	damaging	4.58	24.40	deleterious	0.12	0.4	0.73	disease	0.8	disease	0.7	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	-0.47	medium_impact	2.56	high_impact	0.37	0.8	46.84	9.2	0.72	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12053	12053	C	T	MI.19039	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1294	432	R	W	Cga/Tga	-1.58	0	0	probably_damaging	1	deleterious	0.02	neutral	2.06	deleterious	-6.01	deleterious	-7.24	high_impact	3.86	0.51	damaging	0.05	damaging	5.36	25.90	deleterious	0.07	0.35	0.95	disease	0.79	disease	0.8	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-0.75	medium_impact	2.69	high_impact	0.87	0.9	46.84	9.54	0.35	N	1.00	polymorphism	1	0.13	rs28639786	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	5915	5915	C	A	MI.1904	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	12	4	D	E	gaC/gaA	1.05	0.02	0	benign	0.02	neutral	0.12	neutral	3.03	neutral	0.83	neutral	0.04	neutral_impact	-1.75	0.74	neutral	0.68	neutral	0.96	10.42	neutral	0.54	0.6	0.15	neutral	0.09	neutral	0.12	neutral	0.27	neutral	5	0.88	neutral	0.55	deleterious	-6	neutral	0.07	neutral	0.83	medium_impact	-0.29	medium_impact	-2.72	low_impact	0.33	0.9	13.26	25.03	0.58	P	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12053	12053	C	G	MI.19040	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1294	432	R	G	Cga/Gga	-1.58	0	0	probably_damaging	1	deleterious	0.03	neutral	2.1	deleterious	-3.96	deleterious	-6.33	high_impact	3.86	0.48	damaging	0.1	damaging	4.32	24.00	deleterious	0.07	0.35	0.74	disease	0.7	disease	0.78	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-3.54	low_impact	-0.64	medium_impact	2.69	high_impact	0.26	0.8	46.84	9.54	0.4	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12054	12054	G	C	MI.19041	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1295	432	R	P	cGa/cCa	3.48	0.99	0	probably_damaging	1	deleterious	0.03	neutral	2.09	neutral	-2.21	deleterious	-6.33	high_impact	4.2	0.47	damaging	0.06	damaging	4.39	24.10	deleterious	0.03	0.35	0.45	neutral	0.81	disease	0.84	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.64	medium_impact	3.03	high_impact	0.08	0.8	46.84	9.54	0.63	P	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12054	12054	G	A	MI.19042	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1295	432	R	Q	cGa/cAa	3.48	0.99	0	probably_damaging	1	neutral	0.07	neutral	2.14	deleterious	-3.27	deleterious	-3.62	high_impact	3.86	0.48	damaging	0.05	damaging	4.64	24.50	deleterious	0.18	0.45	0.71	disease	0.78	disease	0.74	disease	0.73	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	-0.43	medium_impact	2.69	high_impact	0.72	0.85	46.84	9.54	0.59	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	COSM6716760	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12054	12054	G	T	MI.19043	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1295	432	R	L	cGa/cTa	3.48	0.99	0	probably_damaging	1	neutral	0.21	neutral	2.12	neutral	-0.13	deleterious	-6.33	high_impact	3.86	0.52	damaging	0.05	damaging	4.43	24.20	deleterious	0.08	0.35	0.59	disease	0.84	disease	0.77	disease	0.78	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.12	medium_impact	2.69	high_impact	0.05	0.8	46.84	9.54	0.55	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12056	12056	G	C	MI.19044	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1297	433	E	Q	Gaa/Caa	0.49	0.99	0	probably_damaging	1	deleterious	0.02	neutral	2.07	deleterious	-3.21	deleterious	-2.71	high_impact	4.21	0.41	damaging	0.53	neutral	3.52	23.10	deleterious	0.23	0.45	0.51	disease	0.77	disease	0.75	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-0.75	medium_impact	3.04	high_impact	0.61	0.8	47.06	9.14	0.76	P	0.91	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12056	12056	G	A	MI.19045	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1297	433	E	K	Gaa/Aaa	0.49	0.99	0	probably_damaging	1	deleterious	0.01	neutral	2.12	neutral	-2.69	deleterious	-3.62	high_impact	4.21	0.41	damaging	0.41	neutral	4.60	24.40	deleterious	0.08	0.35	0.48	neutral	0.87	disease	0.79	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-0.92	medium_impact	3.04	high_impact	0.68	0.85	47.06	9.14	0.79	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	COSM6716727	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12057	12057	A	G	MI.19046	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1298	433	E	G	gAa/gGa	9.01	1	0	probably_damaging	1	deleterious	0.02	neutral	2.03	neutral	-2.42	deleterious	-6.33	high_impact	3.86	0.36	damaging	0.6	neutral	4.17	23.80	deleterious	0.05	0.35	0.78	disease	0.73	disease	0.8	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-0.75	medium_impact	2.69	high_impact	0.17	0.8	47.06	9.14	0.81	P	0.54	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12057	12057	A	T	MI.19047	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1298	433	E	V	gAa/gTa	9.01	1	0	probably_damaging	1	deleterious	0.02	neutral	2.04	neutral	-1.31	deleterious	-6.33	high_impact	4.21	0.4	damaging	0.53	neutral	4.12	23.80	deleterious	0.05	0.35	0.66	disease	0.84	disease	0.79	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.75	medium_impact	3.04	high_impact	0.26	0.8	47.06	9.14	0.82	P	0.81	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12057	12057	A	C	MI.19048	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1298	433	E	A	gAa/gCa	9.01	1	0	probably_damaging	1	deleterious	0.02	neutral	2.09	neutral	-1.91	deleterious	-5.42	high_impact	4.21	0.46	damaging	0.54	neutral	3.60	23.20	deleterious	0.07	0.35	0.63	disease	0.68	disease	0.77	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-0.75	medium_impact	3.04	high_impact	0.23	0.8	47.06	9.14	0.71	P	0.73	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12058	12058	A	C	MI.19049	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1299	433	E	D	gaA/gaC	8.55	1	0	probably_damaging	1	neutral	0.05	neutral	2.07	neutral	-1.51	deleterious	-2.71	high_impact	3.65	0.49	damaging	0.53	neutral	3.78	23.40	deleterious	0.28	0.45	0.55	disease	0.69	disease	0.71	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.74	deleterious	-3.54	low_impact	-0.52	medium_impact	2.49	high_impact	0.49	0.8	47.06	9.14	0.72	P	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5916	5916	C	A	MI.1905	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	13	5	R	S	Cgt/Agt	-6.12	0	0	probably_damaging	1	neutral	0.09	neutral	-1.19	neutral	-0.64	neutral	-0.68	medium_impact	1.98	0.47	damaging	0.08	damaging	4.66	24.50	deleterious	0.28	0.55	0.25	neutral	0.54	disease	0.74	disease	0.7	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.73	deleterious	-3.58	low_impact	-0.37	medium_impact	0.73	medium_impact	0.36	0.9	2.34	6.73	0.36	N	0.79	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12058	12058	A	T	MI.19050	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1299	433	E	D	gaA/gaT	8.55	1	0	probably_damaging	1	neutral	0.05	neutral	2.07	neutral	-1.51	deleterious	-2.71	high_impact	3.65	0.49	damaging	0.53	neutral	3.91	23.50	deleterious	0.28	0.45	0.55	disease	0.69	disease	0.71	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.74	deleterious	-3.54	low_impact	-0.52	medium_impact	2.49	high_impact	0.49	0.8	47.06	9.14	0.72	P	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12059	12059	A	T	MI.19051	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1300	434	N	Y	Aac/Tac	0.49	0.98	0	probably_damaging	0.96	neutral	0.99	neutral	2.23	neutral	0.49	deleterious	-3.08	low_impact	1.08	0.74	neutral	0.69	neutral	3.68	23.30	deleterious	0.14	0.4	0.9	disease	0.39	neutral	0.27	neutral	0.67	disease	3	0.96	neutral	0.52	deleterious	-2	neutral	0.79	deleterious	-2.01	low_impact	1.32	medium_impact	-0.06	medium_impact	0.15	0.8	26.14	20.19	0.37	N	0.84	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12059	12059	A	G	MI.19052	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1300	434	N	D	Aac/Gac	0.49	0.98	0	benign	0.05	neutral	0.07	neutral	2.28	neutral	-0.69	deleterious	-3.03	medium_impact	2.48	0.7	neutral	0.44	neutral	3.84	23.40	deleterious	0.43	0.55	0.59	disease	0.49	neutral	0.63	disease	0.66	disease	3	0.93	neutral	0.51	deleterious	-3	neutral	0.70	deleterious	0.48	medium_impact	-0.43	medium_impact	1.33	medium_impact	0.26	0.8	26.14	20.19	0.51	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12059	12059	A	C	MI.19053	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1300	434	N	H	Aac/Cac	0.49	0.98	0	probably_damaging	0.96	neutral	1	neutral	2.28	neutral	4.61	neutral	0.76	neutral_impact	-0.06	0.68	neutral	0.97	neutral	0.39	6.50	deleterious	0.3	0.45	0.68	disease	0.07	neutral	0.2	neutral	0.38	neutral	3	0.96	neutral	0.52	deleterious	-2	neutral	0.70	deleterious	-2.01	low_impact	1.88	high_impact	-1.19	low_impact	0.20	0.8	26.14	20.19	0.47	N	0.24	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12060	12060	A	T	MI.19054	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1301	434	N	I	aAc/aTc	1.41	0.98	0	probably_damaging	0.92	neutral	0.22	neutral	2.25	neutral	3.81	deleterious	-5.59	medium_impact	2.48	0.74	neutral	0.49	neutral	3.93	23.50	deleterious	0.16	0.45	0.88	disease	0.67	disease	0.53	disease	0.68	disease	4	0.94	neutral	0.15	neutral	1	deleterious	0.82	deleterious	-1.71	low_impact	-0.11	medium_impact	1.33	medium_impact	0.17	0.8	26.14	20.19	0.51	P	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12060	12060	A	C	MI.19055	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1301	434	N	T	aAc/aCc	1.41	0.98	0	possibly_damaging	0.78	neutral	0.1	neutral	2.27	neutral	1.42	deleterious	-3.81	medium_impact	2.48	0.73	neutral	0.54	neutral	3.46	23.00	deleterious	0.24	0.45	0.73	disease	0.44	neutral	0.53	disease	0.66	disease	3	0.93	neutral	0.16	neutral	0	NA	0.76	deleterious	-1.23	low_impact	-0.33	medium_impact	1.33	medium_impact	0.35	0.8	26.14	20.19	0.56	P	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12060	12060	A	G	MI.19056	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1301	434	N	S	aAc/aGc	1.41	0.98	0	possibly_damaging	0.52	neutral	0.15	neutral	2.31	neutral	1.12	deleterious	-2.85	medium_impact	2.28	0.78	neutral	0.77	neutral	3.06	22.40	deleterious	0.44	0.55	0.5	neutral	0.39	neutral	0.42	neutral	0.36	neutral	3	0.84	neutral	0.32	neutral	0	NA	0.72	deleterious	-0.75	medium_impact	-0.22	medium_impact	1.13	medium_impact	0.29	0.8	26.14	20.19	0.54	P	0.41	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12061	12061	C	A	MI.19057	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1302	434	N	K	aaC/aaA	4.63	0.99	0	possibly_damaging	0.73	neutral	0.12	neutral	2.33	neutral	0.4	deleterious	-3.44	medium_impact	2.83	0.73	neutral	0.38	neutral	4.51	24.30	deleterious	0.31	0.45	0.54	disease	0.57	disease	0.64	disease	0.7	disease	4	0.91	neutral	0.2	neutral	0	NA	0.75	deleterious	-1.12	low_impact	-0.28	medium_impact	1.67	medium_impact	0.21	0.8	26.14	20.19	0.61	P	0.74	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12061	12061	C	G	MI.19058	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1302	434	N	K	aaC/aaG	4.63	0.99	0	possibly_damaging	0.73	neutral	0.12	neutral	2.33	neutral	0.4	deleterious	-3.44	medium_impact	2.83	0.73	neutral	0.38	neutral	4.09	23.70	deleterious	0.31	0.45	0.54	disease	0.57	disease	0.64	disease	0.7	disease	4	0.91	neutral	0.2	neutral	0	NA	0.75	deleterious	-1.12	low_impact	-0.28	medium_impact	1.67	medium_impact	0.21	0.8	26.14	20.19	0.61	P	0.74	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12062	12062	A	G	MI.19059	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1303	435	T	A	Acc/Gcc	-5.5	0	0	benign	0.02	neutral	0.06	neutral	2.34	neutral	1.13	neutral	-0.74	low_impact	1.58	0.8	neutral	0.99	neutral	0.18	4.43	deleterious	0.29	0.45	0.39	neutral	0.21	neutral	0.37	neutral	0.37	neutral	3	0.94	neutral	0.52	deleterious	-6	neutral	0.12	neutral	0.87	medium_impact	-0.47	medium_impact	0.44	medium_impact	0.35	0.8	29.63	19.19	0.45	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5916	5916	C	G	MI.1906	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	13	5	R	G	Cgt/Ggt	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	-1.19	neutral	-1.03	neutral	-0.84	medium_impact	2.38	0.5	damaging	0.08	damaging	4.13	23.80	deleterious	0.34	0.55	0.49	neutral	0.53	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	1.1	medium_impact	0.43	0.9	2.34	6.73	0.35	N	0.91	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12062	12062	A	T	MI.19060	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1303	435	T	S	Acc/Tcc	-5.5	0	0	benign	0.03	deleterious	0.04	neutral	2.3	neutral	0.41	neutral	-1.09	low_impact	1.93	0.81	neutral	0.98	neutral	0.27	5.39	deleterious	0.35	0.5	0.54	disease	0.29	neutral	0.31	neutral	0.46	neutral	1	0.96	neutral	0.51	deleterious	-2	neutral	0.15	neutral	0.7	medium_impact	-0.57	medium_impact	0.78	medium_impact	0.57	0.8	29.63	19.19	0.46	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12062	12062	A	C	MI.19061	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1303	435	T	P	Acc/Ccc	-5.5	0	0	benign	0.16	deleterious	0.01	neutral	2.24	neutral	-2.56	deleterious	-2.56	medium_impact	2.62	0.64	neutral	0.39	neutral	1.61	13.89	neutral	0.03	0.35	0.82	disease	0.7	disease	0.61	disease	0.76	disease	5	0.99	deleterious	0.43	neutral	1	deleterious	0.33	neutral	-0.04	medium_impact	-0.92	medium_impact	1.47	medium_impact	0.26	0.8	29.63	19.19	0.29	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12063	12063	C	G	MI.19062	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1304	435	T	S	aCc/aGc	0.03	0	0	benign	0.03	deleterious	0.04	neutral	2.3	neutral	0.41	neutral	-1.09	low_impact	1.93	0.81	neutral	0.98	neutral	0.66	8.57	deleterious	0.35	0.5	0.54	disease	0.29	neutral	0.31	neutral	0.46	neutral	1	0.96	neutral	0.51	deleterious	-2	neutral	0.15	neutral	0.7	medium_impact	-0.57	medium_impact	0.78	medium_impact	0.57	0.8	29.63	19.19	0.45	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12063	12063	C	T	MI.19063	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1304	435	T	I	aCc/aTc	0.03	0	0	benign	0	neutral	0.09	neutral	2.34	neutral	0.78	neutral	-0.33	low_impact	1.27	0.75	neutral	0.96	neutral	1.00	10.68	neutral	0.1	0.4	0.64	disease	0.47	neutral	0.2	neutral	0.61	disease	2	0.91	neutral	0.55	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	-0.36	medium_impact	0.13	medium_impact	0.55	0.8	29.63	19.19	0.5	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12063	12063	C	A	MI.19064	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1304	435	T	N	aCc/aAc	0.03	0	0	benign	0.11	neutral	0.06	neutral	2.25	neutral	-2.25	neutral	-2.35	medium_impact	2.27	0.7	neutral	0.58	neutral	1.88	15.46	deleterious	0.25	0.45	0.79	disease	0.49	neutral	0.47	neutral	0.59	disease	2	0.93	neutral	0.48	deleterious	-3	neutral	0.23	neutral	0.14	medium_impact	-0.47	medium_impact	1.12	medium_impact	0.56	0.8	29.63	19.19	0.4	N	0.36	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12065	12065	C	G	MI.19065	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1306	436	L	V	Ctc/Gtc	-11.02	0	0	probably_damaging	1	neutral	0.14	neutral	2.21	deleterious	-3.02	neutral	-2.48	medium_impact	2.96	0.67	neutral	0.56	neutral	3.57	23.10	deleterious	0.29	0.45	0.86	disease	0.46	neutral	0.47	neutral	0.63	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.24	medium_impact	1.8	medium_impact	0.54	0.8	44.23	8.24	0.4	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12065	12065	C	A	MI.19066	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1306	436	L	I	Ctc/Atc	-11.02	0	0	probably_damaging	1	neutral	0.12	neutral	2.21	neutral	-1.8	neutral	-1.59	medium_impact	2.17	0.76	neutral	0.75	neutral	4.16	23.80	deleterious	0.33	0.5	0.77	disease	0.46	neutral	0.27	neutral	0.61	disease	2	1	deleterious	0.06	neutral	1	deleterious	0.74	deleterious	-3.54	low_impact	-0.28	medium_impact	1.02	medium_impact	0.52	0.8	44.23	8.24	0.42	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12065	12065	C	T	MI.19067	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1306	436	L	F	Ctc/Ttc	-11.02	0	0	probably_damaging	1	neutral	0.07	neutral	2.09	neutral	-1.44	deleterious	-3.5	high_impact	3.76	0.66	neutral	0.45	neutral	4.10	23.70	deleterious	0.16	0.45	0.94	disease	0.59	disease	0.67	disease	0.8	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.80	deleterious	-3.54	low_impact	-0.43	medium_impact	2.59	high_impact	0.67	0.85	44.23	8.24	0.42	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12066	12066	T	G	MI.19068	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1307	436	L	R	cTc/cGc	-0.2	0	0	probably_damaging	1	deleterious	0.02	neutral	2.06	deleterious	-5.14	deleterious	-5.35	high_impact	4.11	0.65	neutral	0.34	neutral	4.35	24.10	deleterious	0.01	0.35	0.38	neutral	0.85	disease	0.79	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-0.75	medium_impact	2.94	high_impact	0.09	0.8	44.23	8.24	0.42	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12066	12066	T	C	MI.19069	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1307	436	L	P	cTc/cCc	-0.2	0	0	probably_damaging	1	deleterious	0.01	neutral	2.08	deleterious	-5.78	deleterious	-6.19	high_impact	3.76	0.58	damaging	0.34	neutral	4.06	23.70	deleterious	0.02	0.35	0.9	disease	0.77	disease	0.78	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.54	low_impact	-0.92	medium_impact	2.59	high_impact	0.08	0.8	44.23	8.24	0.39	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	COSM6716755	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5916	5916	C	T	MI.1907	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	13	5	R	C	Cgt/Tgt	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	-1.2	deleterious	-5.45	neutral	-0.98	high_impact	4.04	0.48	damaging	0.07	damaging	4.92	25.00	deleterious	0.34	0.55	0.8	disease	0.66	disease	0.79	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.63	high_impact	0.75	0.9	2.34	6.73	0.4	N	1.00	disease_causing	0.66	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12066	12066	T	A	MI.19070	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1307	436	L	H	cTc/cAc	-0.2	0	0	probably_damaging	1	deleterious	0.01	neutral	2.04	deleterious	-5.72	deleterious	-6.2	high_impact	4.11	0.67	neutral	0.33	neutral	4.27	23.90	deleterious	0.03	0.35	0.84	disease	0.78	disease	0.75	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.54	low_impact	-0.92	medium_impact	2.94	high_impact	0.12	0.8	44.23	8.24	0.36	N	0.96	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12068	12068	A	T	MI.19071	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1309	437	M	L	Atg/Ttg	-10.1	0	0	probably_damaging	0.94	neutral	0.95	neutral	2.44	neutral	1.41	neutral	-2.18	low_impact	1.47	0.69	neutral	0.27	damaging	2.05	16.56	deleterious	0.22	0.45	0.61	disease	0.38	neutral	0.3	neutral	0.62	disease	2	0.93	neutral	0.51	deleterious	-2	neutral	0.43	neutral	-1.84	low_impact	0.92	medium_impact	0.33	medium_impact	0.34	0.8	47.28	8.68	0.24	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12068	12068	A	C	MI.19072	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1309	437	M	L	Atg/Ctg	-10.1	0	0	probably_damaging	0.94	neutral	0.95	neutral	2.44	neutral	1.41	neutral	-2.18	low_impact	1.47	0.69	neutral	0.27	damaging	2.04	16.48	deleterious	0.22	0.45	0.61	disease	0.38	neutral	0.3	neutral	0.62	disease	2	0.93	neutral	0.51	deleterious	-2	neutral	0.43	neutral	-1.84	low_impact	0.92	medium_impact	0.33	medium_impact	0.34	0.8	47.28	8.68	0.24	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12068	12068	A	G	MI.19073	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1309	437	M	V	Atg/Gtg	-10.1	0	0	probably_damaging	0.97	neutral	0.08	neutral	2.34	neutral	-0.59	deleterious	-3.08	medium_impact	3.37	0.76	neutral	0.28	neutral	2.54	19.74	deleterious	0.21	0.45	0.7	disease	0.68	disease	0.43	neutral	0.51	disease	0	0.99	deleterious	0.06	neutral	1	deleterious	0.53	deleterious	-2.14	low_impact	-0.39	medium_impact	2.21	high_impact	0.38	0.8	47.28	8.68	0.38	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12069	12069	T	A	MI.19074	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1310	437	M	K	aTg/aAg	3.48	0.99	0	probably_damaging	0.98	deleterious	0	neutral	2.21	neutral	-1.23	deleterious	-5.18	high_impact	3.91	0.62	neutral	0.12	damaging	4.14	23.80	deleterious	0.02	0.35	0.6	disease	0.85	disease	0.75	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.71	deleterious	-2.31	low_impact	-1.48	low_impact	2.74	high_impact	0.22	0.8	47.28	8.68	0.54	P	1.00	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12069	12069	T	C	MI.19075	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1310	437	M	T	aTg/aCg	3.48	0.99	0	probably_damaging	0.98	deleterious	0.03	neutral	2.25	neutral	-1.05	deleterious	-5	high_impact	3.56	0.64	neutral	0.14	damaging	3.00	22.20	deleterious	0.06	0.35	0.55	disease	0.73	disease	0.69	disease	0.7	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.71	deleterious	-2.31	low_impact	-0.64	medium_impact	2.4	high_impact	0.12	0.8	47.28	8.68	0.5	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12070	12070	G	T	MI.19076	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1311	437	M	I	atG/atT	5.55	1	0.01	probably_damaging	0.97	neutral	0.41	neutral	2.34	neutral	0.2	deleterious	-2.97	medium_impact	2.08	0.75	neutral	0.79	neutral	2.26	17.91	deleterious	0.21	0.45	0.71	disease	0.55	disease	0.33	neutral	0.51	disease	0	0.97	neutral	0.22	neutral	1	deleterious	0.60	deleterious	-2.14	low_impact	0.11	medium_impact	0.93	medium_impact	0.41	0.8	47.28	8.68	0.61	P	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12070	12070	G	C	MI.19077	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1311	437	M	I	atG/atC	5.55	1	0.01	probably_damaging	0.97	neutral	0.41	neutral	2.34	neutral	0.2	deleterious	-2.97	medium_impact	2.08	0.75	neutral	0.79	neutral	2.12	17.01	deleterious	0.21	0.45	0.71	disease	0.55	disease	0.33	neutral	0.51	disease	0	0.97	neutral	0.22	neutral	1	deleterious	0.60	deleterious	-2.14	low_impact	0.11	medium_impact	0.93	medium_impact	0.41	0.8	47.28	8.68	0.6	P	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12071	12071	T	A	MI.19078	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1312	438	F	I	Ttc/Atc	-0.2	0	0	benign	0.01	neutral	0.34	neutral	2.34	neutral	-0.53	neutral	0.51	low_impact	0.91	0.75	neutral	0.96	neutral	1.21	11.81	neutral	0.14	0.4	0.68	disease	0.44	neutral	0.18	neutral	0.62	disease	2	0.65	neutral	0.67	deleterious	-6	neutral	0.14	neutral	1.16	medium_impact	0.04	medium_impact	-0.23	medium_impact	0.62	0.8	28.32	26.44	0.51	N	0.28	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12071	12071	T	G	MI.19079	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1312	438	F	V	Ttc/Gtc	-0.2	0	0	benign	0.05	neutral	0.23	neutral	2.33	neutral	-0.79	neutral	0.85	low_impact	1.09	0.74	neutral	0.93	neutral	0.67	8.65	deleterious	0.1	0.4	0.55	disease	0.49	neutral	0.2	neutral	0.5	disease	0	0.75	neutral	0.59	deleterious	-6	neutral	0.13	neutral	0.48	medium_impact	-0.09	medium_impact	-0.05	medium_impact	0.51	0.8	28.32	26.44	0.5	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5917	5917	G	C	MI.1908	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	14	5	R	P	cGt/cCt	2.9	0.98	0	probably_damaging	1	deleterious	0	neutral	-1.2	neutral	-2.47	neutral	-0.81	medium_impact	3.34	0.46	damaging	0.08	damaging	4.28	24.00	deleterious	0.18	0.55	0.57	disease	0.69	disease	0.78	disease	0.76	disease	5	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	1.99	medium_impact	0.28	0.9	2.34	6.73	0.55	P	0.99	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12071	12071	T	C	MI.19080	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1312	438	F	L	Ttc/Ctc	-0.2	0	0	benign	0	neutral	0.69	neutral	2.38	neutral	1.54	neutral	0.65	neutral_impact	-0.3	0.79	neutral	0.96	neutral	0.61	8.22	deleterious	0.16	0.45	0.62	disease	0.38	neutral	0.16	neutral	0.61	disease	2	0.3	neutral	0.85	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.4	medium_impact	-1.42	low_impact	0.66	0.8	28.32	26.44	0.41	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12072	12072	T	C	MI.19081	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1313	438	F	S	tTc/tCc	-3.65	0	0	benign	0.01	neutral	0.22	neutral	2.24	neutral	0.95	neutral	1.6	low_impact	0.86	0.79	neutral	0.98	neutral	0.57	7.93	deleterious	0.05	0.35	0.39	neutral	0.42	neutral	0.27	neutral	0.47	neutral	1	0.78	neutral	0.61	deleterious	-6	neutral	0.21	neutral	1.16	medium_impact	-0.11	medium_impact	-0.28	medium_impact	0.32	0.8	28.32	26.44	0.39	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12072	12072	T	A	MI.19082	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1313	438	F	Y	tTc/tAc	-3.65	0	0	benign	0.27	neutral	0.11	neutral	2.21	neutral	-2.27	neutral	-0.28	low_impact	1.92	0.8	neutral	0.85	neutral	0.96	10.44	neutral	0.16	0.45	0.69	disease	0.41	neutral	0.34	neutral	0.63	disease	3	0.87	neutral	0.42	neutral	-6	neutral	0.21	neutral	-0.31	medium_impact	-0.31	medium_impact	0.77	medium_impact	0.68	0.85	28.32	26.44	0.46	N	0.32	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12072	12072	T	G	MI.19083	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1313	438	F	C	tTc/tGc	-3.65	0	0	possibly_damaging	0.75	deleterious	0.02	neutral	2.19	deleterious	-3.29	neutral	0.2	medium_impact	2.27	0.79	neutral	0.48	neutral	2.54	19.73	deleterious	0.05	0.35	0.79	disease	0.67	disease	0.27	neutral	0.54	disease	1	0.98	deleterious	0.14	neutral	4	deleterious	0.49	deleterious	-1.17	low_impact	-0.75	medium_impact	1.12	medium_impact	0.19	0.8	28.32	26.44	0.41	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12073	12073	C	A	MI.19084	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1314	438	F	L	ttC/ttA	-0.43	0	0	benign	0	neutral	0.69	neutral	2.38	neutral	1.54	neutral	0.65	neutral_impact	-0.3	0.79	neutral	0.96	neutral	1.22	11.88	neutral	0.16	0.45	0.62	disease	0.38	neutral	0.16	neutral	0.61	disease	2	0.3	neutral	0.85	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.4	medium_impact	-1.42	low_impact	0.66	0.8	28.32	26.44	0.4	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12073	12073	C	G	MI.19085	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1314	438	F	L	ttC/ttG	-0.43	0	0	benign	0	neutral	0.69	neutral	2.38	neutral	1.54	neutral	0.65	neutral_impact	-0.3	0.79	neutral	0.96	neutral	0.89	10.01	neutral	0.16	0.45	0.62	disease	0.38	neutral	0.16	neutral	0.61	disease	2	0.3	neutral	0.85	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.4	medium_impact	-1.42	low_impact	0.66	0.8	28.32	26.44	0.4	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12074	12074	A	G	MI.19086	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1315	439	M	V	Ata/Gta	-13.78	0	0	benign	0.23	deleterious	0.01	neutral	2.43	neutral	0.99	neutral	-1.44	medium_impact	2.84	0.72	neutral	0.7	neutral	2.59	20.10	deleterious	0.21	0.45	0.42	neutral	0.59	disease	0.51	disease	0.55	disease	1	0.99	deleterious	0.39	neutral	1	deleterious	0.48	deleterious	-0.23	medium_impact	-0.92	medium_impact	1.68	medium_impact	0.34	0.8	21.79	25.23	0.43	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12074	12074	A	C	MI.19087	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1315	439	M	L	Ata/Cta	-13.78	0	0	benign	0.01	neutral	1	neutral	2.54	neutral	4.86	neutral	0.8	neutral_impact	-0.27	0.77	neutral	1	neutral	0.39	6.50	deleterious	0.19	0.45	0.57	disease	0.2	neutral	0.24	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.37	neutral	1.16	medium_impact	1.88	high_impact	-1.39	low_impact	0.28	0.8	21.79	25.23	0.34	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12074	12074	A	T	MI.19088	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1315	439	M	L	Ata/Tta	-13.78	0	0	benign	0.01	neutral	1	neutral	2.54	neutral	4.86	neutral	0.8	neutral_impact	-0.27	0.77	neutral	1	neutral	0.45	7.06	deleterious	0.19	0.45	0.57	disease	0.2	neutral	0.24	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.37	neutral	1.16	medium_impact	1.88	high_impact	-1.39	low_impact	0.28	0.8	21.79	25.23	0.34	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12075	12075	T	A	MI.19089	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1316	439	M	K	aTa/aAa	-1.12	0	0	possibly_damaging	0.69	deleterious	0	neutral	2.26	neutral	2.6	deleterious	-4	medium_impact	3.19	0.66	neutral	0.5	neutral	4.01	23.60	deleterious	0.03	0.35	0.88	disease	0.79	disease	0.71	disease	0.8	disease	6	1	deleterious	0.16	neutral	4	deleterious	0.78	deleterious	-1.04	low_impact	-1.48	low_impact	2.03	high_impact	0.23	0.8	21.79	25.23	0.35	N	0.85	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5917	5917	G	T	MI.1909	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	14	5	R	L	cGt/cTt	2.9	0.98	0	probably_damaging	0.99	deleterious	0	neutral	-1.19	deleterious	-3.4	neutral	-0.84	medium_impact	3.13	0.47	damaging	0.07	damaging	4.31	24.00	deleterious	0.4	0.55	0.47	neutral	0.68	disease	0.76	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	1.79	medium_impact	0.25	0.9	2.34	6.73	0.58	P	0.98	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12075	12075	T	C	MI.19090	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1316	439	M	T	aTa/aCa	-1.12	0	0	possibly_damaging	0.48	deleterious	0.01	neutral	2.31	neutral	1.83	deleterious	-3.27	medium_impact	2.84	0.69	neutral	0.58	neutral	3.01	22.30	deleterious	0.11	0.4	0.72	disease	0.56	disease	0.63	disease	0.69	disease	4	0.99	deleterious	0.27	neutral	4	deleterious	0.70	deleterious	-0.69	medium_impact	-0.92	medium_impact	1.68	medium_impact	0.14	0.8	21.79	25.23	0.36	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12076	12076	A	C	MI.19091	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1317	439	M	I	atA/atC	7.4	0.95	0	benign	0.23	deleterious	0.03	neutral	2.37	neutral	0.4	neutral	-0.74	medium_impact	2.84	0.71	neutral	0.68	neutral	3.36	22.90	deleterious	0.25	0.45	0.43	neutral	0.63	disease	0.47	neutral	0.53	disease	1	0.97	neutral	0.4	neutral	1	deleterious	0.58	deleterious	-0.23	medium_impact	-0.64	medium_impact	1.68	medium_impact	0.40	0.8	21.79	25.23	0.6	P	0.27	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12076	12076	A	T	MI.19092	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1317	439	M	I	atA/atT	7.4	0.95	0	benign	0.23	deleterious	0.03	neutral	2.37	neutral	0.4	neutral	-0.74	medium_impact	2.84	0.71	neutral	0.68	neutral	3.40	23.00	deleterious	0.25	0.45	0.43	neutral	0.63	disease	0.47	neutral	0.53	disease	1	0.97	neutral	0.4	neutral	1	deleterious	0.58	deleterious	-0.23	medium_impact	-0.64	medium_impact	1.68	medium_impact	0.40	0.8	21.79	25.23	0.6	P	0.27	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12077	12077	C	T	MI.19093	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1318	440	H	Y	Cac/Tac	-14.94	0	0	probably_damaging	1	deleterious	0.04	neutral	2.21	neutral	-2.31	deleterious	-5.43	high_impact	4.2	0.51	damaging	0.05	damaging	3.82	23.40	deleterious	0.16	0.45	0.88	disease	0.69	disease	0.77	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-3.54	low_impact	-0.57	medium_impact	3.03	high_impact	0.16	0.8	47.49	9.19	0.38	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12077	12077	C	G	MI.19094	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1318	440	H	D	Cac/Gac	-14.94	0	0	probably_damaging	1	deleterious	0	neutral	2.21	deleterious	-3.46	deleterious	-8.14	high_impact	4.2	0.51	damaging	0.06	damaging	3.98	23.60	deleterious	0.06	0.35	0.89	disease	0.72	disease	0.83	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.27	0.8	47.49	9.19	0.41	N	0.97	polymorphism	1	0.38	.	.	.	.	.	.	COSM6716735	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12077	12077	C	A	MI.19095	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1318	440	H	N	Cac/Aac	-14.94	0	0	probably_damaging	1	neutral	0.1	neutral	2.22	neutral	-2.07	deleterious	-6.33	high_impact	4.2	0.5	damaging	0.07	damaging	4.00	23.60	deleterious	0.21	0.45	0.83	disease	0.65	disease	0.76	disease	0.75	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	-0.33	medium_impact	3.03	high_impact	0.37	0.8	47.49	9.19	0.37	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12078	12078	A	T	MI.19096	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1319	440	H	L	cAc/cTc	5.32	1	0	probably_damaging	1	neutral	0.11	neutral	2.41	neutral	-1.8	deleterious	-9.95	high_impact	4.2	0.53	damaging	0.05	damaging	3.82	23.40	deleterious	0.05	0.35	0.72	disease	0.8	disease	0.75	disease	0.77	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.77	deleterious	-3.54	low_impact	-0.31	medium_impact	3.03	high_impact	0.14	0.8	47.49	9.19	0.64	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12078	12078	A	G	MI.19097	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1319	440	H	R	cAc/cGc	5.32	1	0	probably_damaging	1	deleterious	0	neutral	2.22	neutral	0.1	deleterious	-7.24	high_impact	4.2	0.59	damaging	0.06	damaging	2.99	22.20	deleterious	0.09	0.35	0.85	disease	0.75	disease	0.79	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.26	0.8	47.49	9.19	0.62	P	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12078	12078	A	C	MI.19098	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1319	440	H	P	cAc/cCc	5.32	1	0	probably_damaging	1	deleterious	0	neutral	2.22	neutral	-2.09	deleterious	-9.05	high_impact	3.65	0.52	damaging	0.08	damaging	3.26	22.80	deleterious	0.05	0.35	0.86	disease	0.77	disease	0.8	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.54	low_impact	-1.48	low_impact	2.49	high_impact	0.19	0.8	47.49	9.19	0.62	P	0.95	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12079	12079	C	G	MI.19099	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1320	440	H	Q	caC/caG	8.55	1	0	probably_damaging	1	deleterious	0	neutral	2.22	deleterious	-3.1	deleterious	-7.24	high_impact	4.2	0.54	damaging	0.06	damaging	3.72	23.30	deleterious	0.11	0.4	0.85	disease	0.69	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.31	0.8	47.49	9.19	0.62	P	0.93	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8616	8616	G	C	MI.191	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	90	30	L	F	ttG/ttC	7.53	0.96	0.02	probably_damaging	1	neutral	0.39	neutral	4.31	neutral	-0.71	deleterious	-3.18	low_impact	1.63	0.91	neutral	0.87	neutral	2.21	17.59	deleterious	0.41	0.65	0.66	disease	0.4	neutral	0.15	neutral	0.62	disease	2	1	deleterious	0.2	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.18	medium_impact	0.3	medium_impact	0.59	0.9	17.7	14.1	0.54	P	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5917	5917	G	A	MI.1910	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	14	5	R	H	cGt/cAt	2.9	0.98	0	probably_damaging	1	deleterious	0	neutral	-1.2	deleterious	-3.15	neutral	-0.6	medium_impact	3.23	0.47	damaging	0.07	damaging	4.30	24.00	deleterious	0.47	0.55	0.53	disease	0.51	disease	0.75	disease	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	1.88	medium_impact	0.84	0.9	2.34	6.73	0.58	P	0.98	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12079	12079	C	A	MI.19100	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1320	440	H	Q	caC/caA	8.55	1	0	probably_damaging	1	deleterious	0	neutral	2.22	deleterious	-3.1	deleterious	-7.24	high_impact	4.2	0.54	damaging	0.06	damaging	4.05	23.70	deleterious	0.11	0.4	0.85	disease	0.69	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.31	0.8	47.49	9.19	0.63	P	0.93	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12080	12080	C	G	MI.19101	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1321	441	L	V	Cta/Gta	-3.19	0	0	benign	0.14	neutral	0.23	neutral	2.17	neutral	-2.66	neutral	-1.18	medium_impact	2.47	0.84	neutral	0.86	neutral	3.47	23.00	deleterious	0.33	0.5	0.58	disease	0.37	neutral	0.14	neutral	0.61	disease	2	0.73	neutral	0.55	deleterious	-3	neutral	0.68	deleterious	0.02	medium_impact	-0.09	medium_impact	1.32	medium_impact	0.47	0.8	7.84	16.1	0.5	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12080	12080	C	A	MI.19102	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1321	441	L	M	Cta/Ata	-3.19	0	0	benign	0.07	neutral	0.21	neutral	2.07	neutral	-2.67	neutral	-0.69	low_impact	1.31	0.8	neutral	0.96	neutral	2.78	21.30	deleterious	0.28	0.45	0.55	disease	0.22	neutral	0.12	neutral	0.49	neutral	0	0.77	neutral	0.57	deleterious	-6	neutral	0.68	deleterious	0.34	medium_impact	-0.12	medium_impact	0.17	medium_impact	0.37	0.8	7.84	16.1	0.5	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12081	12081	T	A	MI.19103	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1322	441	L	Q	cTa/cAa	-0.66	0	0	possibly_damaging	0.77	deleterious	0.03	neutral	2.02	neutral	-1.89	deleterious	-4.21	high_impact	3.71	0.66	neutral	0.53	neutral	4.26	23.90	deleterious	0.03	0.35	0.86	disease	0.69	disease	0.44	neutral	0.62	disease	2	0.98	neutral	0.13	neutral	5	deleterious	0.78	deleterious	-1.21	low_impact	-0.64	medium_impact	2.54	high_impact	0.12	0.8	7.84	16.1	0.46	N	0.83	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12081	12081	T	C	MI.19104	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1322	441	L	P	cTa/cCa	-0.66	0	0	possibly_damaging	0.87	deleterious	0.02	neutral	2.01	deleterious	-5.33	deleterious	-4.96	high_impact	3.71	0.62	neutral	0.39	neutral	4.07	23.70	deleterious	0.02	0.35	0.88	disease	0.81	disease	0.6	disease	0.77	disease	5	0.99	deleterious	0.08	neutral	5	deleterious	0.85	deleterious	-1.49	low_impact	-0.75	medium_impact	2.54	high_impact	0.17	0.8	7.84	16.1	0.37	N	0.93	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12081	12081	T	G	MI.19105	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1322	441	L	R	cTa/cGa	-0.66	0	0	possibly_damaging	0.77	neutral	0.06	neutral	2.02	deleterious	-4.63	deleterious	-4.38	high_impact	3.71	0.62	neutral	0.45	neutral	4.37	24.10	deleterious	0.02	0.35	0.84	disease	0.81	disease	0.6	disease	0.77	disease	5	0.96	neutral	0.15	neutral	1	deleterious	0.83	deleterious	-1.21	low_impact	-0.47	medium_impact	2.54	high_impact	0.08	0.8	7.84	16.1	0.42	N	0.87	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12083	12083	T	A	MI.19106	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1324	442	S	T	Tcc/Acc	-9.87	0	0.03	benign	0	neutral	0.16	neutral	2.3	neutral	2.18	neutral	0.72	neutral_impact	-0.44	0.78	neutral	0.99	neutral	0.77	9.30	deleterious	0.26	0.45	0.83	disease	0.11	neutral	0.09	neutral	0.43	neutral	1	0.84	neutral	0.58	deleterious	-6	neutral	0.19	neutral	2.1	high_impact	-0.2	medium_impact	-1.56	low_impact	0.41	0.8	26.58	30.72	0.52	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12083	12083	T	C	MI.19107	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1324	442	S	P	Tcc/Ccc	-9.87	0	0.03	benign	0.3	deleterious	0.01	neutral	2.23	neutral	1.92	neutral	-1.11	low_impact	1.59	0.6	neutral	0.39	neutral	2.26	17.90	deleterious	0.09	0.35	0.97	disease	0.62	disease	0.44	neutral	0.83	disease	7	0.99	deleterious	0.36	neutral	-2	neutral	0.47	deleterious	-0.37	medium_impact	-0.92	medium_impact	0.45	medium_impact	0.28	0.8	26.58	30.72	0.35	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12083	12083	T	G	MI.19108	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1324	442	S	A	Tcc/Gcc	-9.87	0	0.03	benign	0	neutral	0.14	neutral	2.38	neutral	1.37	neutral	0.7	neutral_impact	-1	0.75	neutral	0.99	neutral	0.56	7.89	deleterious	0.31	0.45	0.84	disease	0.09	neutral	0.11	neutral	0.41	neutral	2	0.86	neutral	0.57	deleterious	-6	neutral	0.18	neutral	2.1	high_impact	-0.24	medium_impact	-2.12	low_impact	0.29	0.8	26.58	30.72	0.55	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12084	12084	C	G	MI.19109	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1325	442	S	C	tCc/tGc	-7.57	0	0.01	possibly_damaging	0.57	deleterious	0.03	neutral	2.22	neutral	-2.02	neutral	0.44	low_impact	1.04	0.69	neutral	0.42	neutral	2.00	16.21	deleterious	0.1	0.4	0.97	disease	0.34	neutral	0.36	neutral	0.66	disease	3	0.97	neutral	0.23	neutral	1	deleterious	0.49	deleterious	-0.83	medium_impact	-0.64	medium_impact	-0.1	medium_impact	0.23	0.8	26.58	30.72	0.43	N	0.37	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5919	5919	T	C	MI.1911	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	16	6	W	R	Tga/Cga	-4.96	0	0	probably_damaging	1	deleterious	0	deleterious	-1.86	deleterious	-6	neutral	-1.89	high_impact	3.68	0.63	neutral	0.09	damaging	3.57	23.10	deleterious	0.34	0.55	0.91	disease	0.82	disease	0.86	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.3	high_impact	0.22	0.9	3.12	6.72	0.35	N	0.94	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12084	12084	C	A	MI.19110	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1325	442	S	Y	tCc/tAc	-7.57	0	0.01	benign	0.14	neutral	0.08	neutral	2.24	neutral	-1.1	neutral	0.39	neutral_impact	0.78	0.77	neutral	0.61	neutral	2.40	18.79	deleterious	0.09	0.4	0.95	disease	0.32	neutral	0.43	neutral	0.64	disease	3	0.91	neutral	0.47	deleterious	-6	neutral	0.25	neutral	0.02	medium_impact	-0.39	medium_impact	-0.35	medium_impact	0.23	0.8	26.58	30.72	0.41	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12084	12084	C	T	MI.19111	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1325	442	S	F	tCc/tTc	-7.57	0	0.01	benign	0	neutral	0.78	neutral	2.29	neutral	1.42	neutral	1.21	neutral_impact	-0.2	0.83	neutral	0.9	neutral	1.28	12.15	neutral	0.09	0.35	0.93	disease	0.26	neutral	0.16	neutral	0.58	disease	2	0.21	neutral	0.89	deleterious	-6	neutral	0.22	neutral	2.1	high_impact	0.51	medium_impact	-1.32	low_impact	0.16	0.8	26.58	30.72	0.36	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12086	12086	C	T	MI.19112	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1327	443	P	S	Ccc/Tcc	-5.73	0	0	probably_damaging	1	deleterious	0.01	neutral	2.14	deleterious	-3.41	deleterious	-7.22	high_impact	4.2	0.57	damaging	0.53	neutral	4.07	23.70	deleterious	0.17	0.45	0.6	disease	0.67	disease	0.6	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-0.92	medium_impact	3.03	high_impact	0.11	0.8	47.06	9.61	0.4	N	0.68	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12086	12086	C	G	MI.19113	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1327	443	P	A	Ccc/Gcc	-5.73	0	0	probably_damaging	1	deleterious	0.04	neutral	2.18	neutral	-2.82	deleterious	-7.22	high_impact	3.86	0.62	neutral	0.51	neutral	3.25	22.80	deleterious	0.15	0.4	0.4	neutral	0.5	neutral	0.7	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.71	deleterious	-3.54	low_impact	-0.57	medium_impact	2.69	high_impact	0.50	0.8	47.06	9.61	0.45	N	0.74	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12086	12086	C	A	MI.19114	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1327	443	P	T	Ccc/Acc	-5.73	0	0	probably_damaging	1	deleterious	0	neutral	2.15	neutral	-1.85	deleterious	-7.22	high_impact	3.86	0.59	damaging	0.47	neutral	3.87	23.50	deleterious	0.14	0.4	0.73	disease	0.68	disease	0.7	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.54	low_impact	-1.48	low_impact	2.69	high_impact	0.43	0.8	47.06	9.61	0.38	N	0.88	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12087	12087	C	A	MI.19115	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1328	443	P	H	cCc/cAc	5.32	0.99	0	probably_damaging	1	deleterious	0.02	neutral	2.09	neutral	-1.63	deleterious	-8.13	high_impact	4.2	0.61	neutral	0.39	neutral	4.19	23.80	deleterious	0.08	0.35	0.87	disease	0.79	disease	0.8	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-0.75	medium_impact	3.03	high_impact	0.20	0.8	47.06	9.61	0.67	P	0.70	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12087	12087	C	T	MI.19116	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1328	443	P	L	cCc/cTc	5.32	0.99	0	probably_damaging	1	deleterious	0.04	neutral	2.24	neutral	-2.31	deleterious	-9.03	high_impact	3.86	0.57	damaging	0.45	neutral	4.57	24.40	deleterious	0.15	0.4	0.53	disease	0.77	disease	0.67	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.75	deleterious	-3.54	low_impact	-0.57	medium_impact	2.69	high_impact	0.55	0.8	47.06	9.61	0.62	P	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12087	12087	C	G	MI.19117	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1328	443	P	R	cCc/cGc	5.32	0.99	0	probably_damaging	1	deleterious	0	neutral	2.11	deleterious	-4.24	deleterious	-8.13	high_impact	4.2	0.66	neutral	0.44	neutral	3.76	23.30	deleterious	0.05	0.35	0.79	disease	0.82	disease	0.83	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.54	low_impact	-1.48	low_impact	3.03	high_impact	0.25	0.8	47.06	9.61	0.65	P	0.62	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12089	12089	A	T	MI.19118	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1330	444	I	F	Att/Ttt	-9.18	0	0	benign	0.25	neutral	0.06	neutral	2.14	neutral	-1.21	neutral	-2.24	medium_impact	2.84	0.75	neutral	0.46	neutral	2.27	17.94	deleterious	0.16	0.45	0.87	disease	0.35	neutral	0.49	neutral	0.66	disease	3	0.93	neutral	0.41	neutral	-3	neutral	0.26	neutral	-0.27	medium_impact	-0.47	medium_impact	1.68	medium_impact	0.45	0.8	25.49	30.07	0.39	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12089	12089	A	C	MI.19119	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1330	444	I	L	Att/Ctt	-9.18	0	0	benign	0	neutral	1	neutral	2.38	neutral	0.92	neutral	0.56	neutral_impact	-0.28	0.8	neutral	0.97	neutral	-0.67	0.09	neutral	0.24	0.45	0.39	neutral	0.08	neutral	0.1	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	1.88	high_impact	-1.4	low_impact	0.50	0.8	25.49	30.07	0.4	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5919	5919	T	G	MI.1912	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	16	6	W	G	Tga/Gga	-4.96	0	0	probably_damaging	1	deleterious	0	deleterious	-1.85	deleterious	-6.18	neutral	-1.76	high_impact	4.03	0.65	neutral	0.08	damaging	3.89	23.50	deleterious	0.25	0.55	0.92	disease	0.76	disease	0.83	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.62	high_impact	0.24	0.9	3.12	6.72	0.36	N	0.90	polymorphism	0.98	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12089	12089	A	G	MI.19120	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1330	444	I	V	Att/Gtt	-9.18	0	0	benign	0.07	neutral	0.14	neutral	2.29	neutral	-1.56	neutral	-0.61	low_impact	1.8	0.76	neutral	0.87	neutral	-0.08	1.91	neutral	0.43	0.55	0.43	neutral	0.11	neutral	0.19	neutral	0.34	neutral	3	0.85	neutral	0.54	deleterious	-6	neutral	0.11	neutral	0.34	medium_impact	-0.24	medium_impact	0.66	medium_impact	0.31	0.8	25.49	30.07	0.59	P	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12090	12090	T	A	MI.19121	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1331	444	I	N	aTt/aAt	-0.2	0	0	possibly_damaging	0.51	deleterious	0.03	neutral	2.11	deleterious	-3.48	deleterious	-4.66	medium_impact	2.84	0.75	neutral	0.47	neutral	2.82	21.50	deleterious	0.15	0.4	0.88	disease	0.46	neutral	0.52	disease	0.68	disease	4	0.97	neutral	0.26	neutral	4	deleterious	0.58	deleterious	-0.73	medium_impact	-0.64	medium_impact	1.68	medium_impact	0.13	0.8	25.49	30.07	0.4	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12090	12090	T	C	MI.19122	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1331	444	I	T	aTt/aCt	-0.2	0	0	benign	0.01	deleterious	0.02	neutral	2.19	neutral	-2.28	deleterious	-2.8	low_impact	1.13	0.76	neutral	0.85	neutral	0.48	7.27	deleterious	0.14	0.4	0.84	disease	0.2	neutral	0.22	neutral	0.5	disease	0	0.98	neutral	0.51	deleterious	-2	neutral	0.26	neutral	1.16	medium_impact	-0.75	medium_impact	-0.01	medium_impact	0.26	0.8	25.49	30.07	0.39	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12090	12090	T	G	MI.19123	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1331	444	I	S	aTt/aGt	-0.2	0	0	benign	0.16	deleterious	0.03	neutral	2.14	neutral	-2.49	deleterious	-3.75	low_impact	1.94	0.76	neutral	0.72	neutral	2.59	20.10	deleterious	0.06	0.35	0.46	neutral	0.38	neutral	0.24	neutral	0.48	neutral	0	0.97	neutral	0.44	neutral	-2	neutral	0.32	neutral	-0.04	medium_impact	-0.64	medium_impact	0.79	medium_impact	0.16	0.8	25.49	30.07	0.47	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12091	12091	T	A	MI.19124	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1332	444	I	M	atT/atA	3.71	0.35	0	benign	0.43	neutral	0.23	neutral	2.16	neutral	-2.84	neutral	-0.37	neutral_impact	0.61	0.73	neutral	0.75	neutral	0.67	8.62	deleterious	0.34	0.5	0.67	disease	0.08	neutral	0.14	neutral	0.41	neutral	2	0.73	neutral	0.4	neutral	-6	neutral	0.25	neutral	-0.6	medium_impact	-0.09	medium_impact	-0.52	medium_impact	0.53	0.8	25.49	30.07	0.55	P	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12091	12091	T	G	MI.19125	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1332	444	I	M	atT/atG	3.71	0.35	0	benign	0.43	neutral	0.23	neutral	2.16	neutral	-2.84	neutral	-0.37	neutral_impact	0.61	0.73	neutral	0.75	neutral	0.32	5.87	deleterious	0.34	0.5	0.67	disease	0.08	neutral	0.14	neutral	0.41	neutral	2	0.73	neutral	0.4	neutral	-6	neutral	0.25	neutral	-0.6	medium_impact	-0.09	medium_impact	-0.52	medium_impact	0.53	0.8	25.49	30.07	0.54	P	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12092	12092	C	A	MI.19126	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1333	445	L	I	Ctc/Atc	-5.73	0	0.02	benign	0.02	neutral	0.4	neutral	2.26	neutral	-0.35	neutral	-0.47	neutral_impact	-0.17	0.77	neutral	0.97	neutral	1.91	15.62	deleterious	0.29	0.45	0.76	disease	0.11	neutral	0.09	neutral	0.39	neutral	2	0.58	neutral	0.69	deleterious	-6	neutral	0.67	deleterious	0.87	medium_impact	0.1	medium_impact	-1.29	low_impact	0.38	0.8	27.89	22.42	0.43	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12092	12092	C	G	MI.19127	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1333	445	L	V	Ctc/Gtc	-5.73	0	0.02	benign	0.21	neutral	0.51	neutral	2.21	neutral	-0.5	neutral	-1.16	low_impact	1.67	0.8	neutral	0.94	neutral	2.35	18.48	deleterious	0.27	0.45	0.7	disease	0.28	neutral	0.16	neutral	0.59	disease	2	0.39	neutral	0.65	deleterious	-6	neutral	0.68	deleterious	-0.18	medium_impact	0.21	medium_impact	0.53	medium_impact	0.49	0.8	27.89	22.42	0.4	N	0.43	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12092	12092	C	T	MI.19128	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1333	445	L	F	Ctc/Ttc	-5.73	0	0.02	possibly_damaging	0.74	neutral	0.7	neutral	2.09	neutral	-2.38	neutral	-2.42	low_impact	1.75	0.78	neutral	0.84	neutral	4.09	23.70	deleterious	0.24	0.45	0.81	disease	0.34	neutral	0.18	neutral	0.65	disease	3	0.69	neutral	0.48	deleterious	-3	neutral	0.72	deleterious	-1.14	low_impact	0.41	medium_impact	0.61	medium_impact	0.47	0.8	27.89	22.42	0.32	N	0.36	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12093	12093	T	C	MI.19129	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1334	445	L	P	cTc/cCc	-6.19	0	0	probably_damaging	0.92	neutral	0.2	neutral	2.04	deleterious	-4.35	deleterious	-5.08	medium_impact	3.21	0.62	neutral	0.37	neutral	4.02	23.60	deleterious	0.03	0.35	0.87	disease	0.75	disease	0.65	disease	0.77	disease	5	0.95	neutral	0.14	neutral	1	deleterious	0.84	deleterious	-1.71	low_impact	-0.14	medium_impact	2.05	high_impact	0.21	0.8	27.89	22.42	0.29	N	0.94	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5920	5920	G	C	MI.1913	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	17	6	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	deleterious	-1.86	deleterious	-5.39	neutral	-1.89	high_impact	3.83	0.64	neutral	0.09	damaging	4.00	23.60	deleterious	0.23	0.55	0.87	disease	0.81	disease	0.81	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.44	high_impact	0.20	0.9	3.12	6.72	0.52	P	0.88	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12093	12093	T	G	MI.19130	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1334	445	L	R	cTc/cGc	-6.19	0	0	probably_damaging	0.92	neutral	0.35	neutral	2.05	deleterious	-3.72	deleterious	-4.55	medium_impact	3.21	0.67	neutral	0.45	neutral	4.27	24.00	deleterious	0.02	0.35	0.76	disease	0.78	disease	0.64	disease	0.76	disease	5	0.92	neutral	0.22	neutral	1	deleterious	0.82	deleterious	-1.71	low_impact	0.05	medium_impact	2.05	high_impact	0.09	0.8	27.89	22.42	0.31	N	0.92	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12093	12093	T	A	MI.19131	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1334	445	L	H	cTc/cAc	-6.19	0	0	probably_damaging	0.94	neutral	0.54	neutral	2.04	deleterious	-4.33	deleterious	-5.04	medium_impact	3.21	0.74	neutral	0.54	neutral	4.21	23.90	deleterious	0.05	0.35	0.86	disease	0.62	disease	0.59	disease	0.71	disease	4	0.94	neutral	0.3	neutral	1	deleterious	0.77	deleterious	-1.84	low_impact	0.24	medium_impact	2.05	high_impact	0.13	0.8	27.89	22.42	0.28	N	0.84	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12095	12095	C	A	MI.19132	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1336	446	L	I	Ctc/Atc	-10.33	0	0	benign	0.42	neutral	0.2	neutral	2.17	deleterious	-3.61	neutral	-1.58	medium_impact	2.62	0.78	neutral	0.77	neutral	3.14	22.60	deleterious	0.3	0.45	0.75	disease	0.42	neutral	0.37	neutral	0.62	disease	2	0.77	neutral	0.39	neutral	-3	neutral	0.71	deleterious	-0.59	medium_impact	-0.14	medium_impact	1.47	medium_impact	0.42	0.8	16.99	17.81	0.38	N	0.15	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12095	12095	C	T	MI.19133	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1336	446	L	F	Ctc/Ttc	-10.33	0	0	benign	0.03	neutral	0.16	neutral	2.09	neutral	-1.32	deleterious	-3.4	medium_impact	2.67	0.72	neutral	0.64	neutral	4.13	23.80	deleterious	0.29	0.45	0.83	disease	0.42	neutral	0.43	neutral	0.64	disease	3	0.83	neutral	0.57	deleterious	-3	neutral	0.75	deleterious	0.7	medium_impact	-0.2	medium_impact	1.52	medium_impact	0.52	0.8	16.99	17.81	0.42	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12095	12095	C	G	MI.19134	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1336	446	L	V	Ctc/Gtc	-10.33	0	0	benign	0.42	deleterious	0.03	neutral	2.17	neutral	-1.44	neutral	-2.43	medium_impact	3.26	0.69	neutral	0.53	neutral	3.56	23.10	deleterious	0.29	0.45	0.67	disease	0.46	neutral	0.57	disease	0.63	disease	3	0.97	neutral	0.31	neutral	1	deleterious	0.72	deleterious	-0.59	medium_impact	-0.64	medium_impact	2.1	high_impact	0.54	0.8	16.99	17.81	0.41	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12096	12096	T	G	MI.19135	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1337	446	L	R	cTc/cGc	0.49	0.1	0	possibly_damaging	0.84	deleterious	0	neutral	2.04	deleterious	-3.66	deleterious	-5.18	high_impact	4.07	0.56	damaging	0.4	neutral	4.36	24.10	deleterious	0.03	0.35	0.55	disease	0.83	disease	0.72	disease	0.77	disease	5	1	deleterious	0.08	neutral	5	deleterious	0.81	deleterious	-1.39	low_impact	-1.48	low_impact	2.9	high_impact	0.12	0.8	16.99	17.81	0.44	N	0.98	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12096	12096	T	C	MI.19136	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1337	446	L	P	cTc/cCc	0.49	0.1	0	possibly_damaging	0.88	deleterious	0.01	neutral	2.01	deleterious	-4.87	deleterious	-6.01	medium_impact	3.17	0.57	damaging	0.46	neutral	4.02	23.60	deleterious	0.03	0.35	0.74	disease	0.72	disease	0.66	disease	0.64	disease	3	1	deleterious	0.07	neutral	4	deleterious	0.82	deleterious	-1.53	low_impact	-0.92	medium_impact	2.01	high_impact	0.27	0.8	16.99	17.81	0.36	N	0.94	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12096	12096	T	A	MI.19137	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1337	446	L	H	cTc/cAc	0.49	0.1	0	probably_damaging	0.94	deleterious	0	neutral	2.01	neutral	-1.89	deleterious	-6.03	high_impact	4.07	0.63	neutral	0.4	neutral	4.31	24.00	deleterious	0.06	0.35	0.56	disease	0.73	disease	0.68	disease	0.7	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.75	deleterious	-1.84	low_impact	-1.48	low_impact	2.9	high_impact	0.12	0.8	16.99	17.81	0.45	N	0.86	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12098	12098	C	A	MI.19138	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1339	447	L	M	Cta/Ata	-20	0	0	probably_damaging	1	neutral	0.17	neutral	2	neutral	-1.06	neutral	-1.59	medium_impact	2.69	0.78	neutral	0.21	damaging	3.86	23.50	deleterious	0.23	0.45	0.59	disease	0.39	neutral	0.36	neutral	0.57	disease	1	1	deleterious	0.09	neutral	1	deleterious	0.71	deleterious	-3.54	low_impact	-0.18	medium_impact	1.54	medium_impact	0.48	0.8	17.21	14.68	0.34	N	0.65	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12098	12098	C	G	MI.19139	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1339	447	L	V	Cta/Gta	-20	0	0	probably_damaging	1	deleterious	0.03	neutral	2.07	neutral	0.21	neutral	-2.27	medium_impact	2.94	0.65	neutral	0.15	damaging	3.54	23.10	deleterious	0.27	0.45	0.74	disease	0.5	neutral	0.46	neutral	0.49	neutral	0	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-3.54	low_impact	-0.64	medium_impact	1.78	medium_impact	0.51	0.8	17.21	14.68	0.32	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5920	5920	G	T	MI.1914	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	17	6	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	deleterious	-1.85	deleterious	-3.75	neutral	-1.75	medium_impact	2.79	0.69	neutral	0.07	damaging	4.26	23.90	deleterious	0.19	0.55	0.71	disease	0.69	disease	0.82	disease	0.78	disease	6	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	1.48	medium_impact	0.19	0.9	3.12	6.72	0.5	N	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12099	12099	T	A	MI.19140	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1340	447	L	Q	cTa/cAa	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	1.94	neutral	-2.83	deleterious	-5.04	high_impact	4.04	0.61	neutral	0.12	damaging	4.23	23.90	deleterious	0.05	0.35	0.95	disease	0.73	disease	0.62	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.13	0.8	17.21	14.68	0.31	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12099	12099	T	C	MI.19141	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1340	447	L	P	cTa/cCa	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	1.94	deleterious	-3.66	deleterious	-5.85	high_impact	4.04	0.54	damaging	0.13	damaging	4.07	23.70	deleterious	0.04	0.35	0.96	disease	0.77	disease	0.75	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.16	0.8	17.21	14.68	0.33	N	0.94	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12099	12099	T	G	MI.19142	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1340	447	L	R	cTa/cGa	-0.2	0	0	probably_damaging	1	deleterious	0	neutral	1.95	neutral	-0.16	deleterious	-5.04	high_impact	4.04	0.68	neutral	0.13	damaging	4.35	24.10	deleterious	0.03	0.35	0.95	disease	0.84	disease	0.75	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.54	low_impact	-1.48	low_impact	2.87	high_impact	0.10	0.8	17.21	14.68	0.31	N	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12101	12101	T	A	MI.19143	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1342	448	S	T	Tcc/Acc	-4.81	0	0	benign	0.01	neutral	0.13	neutral	2.29	neutral	0.74	neutral	0.45	neutral_impact	0.51	0.88	neutral	0.98	neutral	0.21	4.75	deleterious	0.32	0.5	0.49	neutral	0.23	neutral	0.17	neutral	0.4	neutral	2	0.87	neutral	0.56	deleterious	-6	neutral	0.14	neutral	1.16	medium_impact	-0.26	medium_impact	-0.62	medium_impact	0.62	0.8	25.05	16.6	0.57	P	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12101	12101	T	C	MI.19144	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1342	448	S	P	Tcc/Ccc	-4.81	0	0	possibly_damaging	0.7	deleterious	0.01	neutral	2.22	deleterious	-3.04	neutral	-2.24	medium_impact	3.19	0.75	neutral	0.41	neutral	2.25	17.87	deleterious	0.09	0.35	0.47	neutral	0.82	disease	0.49	neutral	0.73	disease	5	0.99	deleterious	0.16	neutral	4	deleterious	0.43	neutral	-1.06	low_impact	-0.92	medium_impact	2.03	high_impact	0.22	0.8	25.05	16.6	0.4	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12101	12101	T	G	MI.19145	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1342	448	S	A	Tcc/Gcc	-4.81	0	0	benign	0.22	deleterious	0.02	neutral	2.31	neutral	-0.8	neutral	-0.74	medium_impact	2.08	0.76	neutral	0.76	neutral	0.70	8.85	deleterious	0.32	0.5	0.47	neutral	0.31	neutral	0.35	neutral	0.46	neutral	1	0.98	neutral	0.4	neutral	1	deleterious	0.19	neutral	-0.2	medium_impact	-0.75	medium_impact	0.93	medium_impact	0.34	0.8	25.05	16.6	0.46	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12102	12102	C	G	MI.19146	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1343	448	S	C	tCc/tGc	-0.2	0	0	possibly_damaging	0.87	deleterious	0.04	neutral	2.21	neutral	-2.82	neutral	-1.61	medium_impact	2.84	0.68	neutral	0.41	neutral	3.31	22.90	deleterious	0.11	0.4	0.86	disease	0.61	disease	0.49	neutral	0.59	disease	2	0.98	deleterious	0.09	neutral	4	deleterious	0.63	deleterious	-1.49	low_impact	-0.57	medium_impact	1.68	medium_impact	0.24	0.8	25.05	16.6	0.39	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12102	12102	C	A	MI.19147	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1343	448	S	Y	tCc/tAc	-0.2	0	0	possibly_damaging	0.87	deleterious	0.04	neutral	2.23	neutral	-2.01	neutral	-2.13	medium_impact	3.19	0.73	neutral	0.49	neutral	2.75	21.10	deleterious	0.09	0.35	0.78	disease	0.63	disease	0.54	disease	0.7	disease	4	0.98	deleterious	0.09	neutral	4	deleterious	0.60	deleterious	-1.49	low_impact	-0.57	medium_impact	2.03	high_impact	0.18	0.8	25.05	16.6	0.42	N	0.99	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12102	12102	C	T	MI.19148	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1343	448	S	F	tCc/tTc	-0.2	0	0	possibly_damaging	0.82	neutral	0.3	neutral	2.26	neutral	1.45	neutral	-1.81	medium_impact	2.04	0.71	neutral	0.48	neutral	2.76	21.10	deleterious	0.09	0.35	0.69	disease	0.64	disease	0.28	neutral	0.53	disease	1	0.85	neutral	0.24	neutral	0	NA	0.58	deleterious	-1.34	low_impact	0	medium_impact	0.89	medium_impact	0.09	0.8	25.05	16.6	0.38	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12104	12104	C	A	MI.19149	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1345	449	L	I	Ctc/Atc	-8.72	0	0	benign	0.06	neutral	0.27	neutral	2.19	neutral	-0.7	neutral	-0.62	medium_impact	1.98	0.83	neutral	0.98	neutral	0.83	9.65	deleterious	0.35	0.5	0.37	neutral	0.21	neutral	0.13	neutral	0.38	neutral	2	0.7	neutral	0.61	deleterious	-3	neutral	0.13	neutral	0.41	medium_impact	-0.04	medium_impact	0.83	medium_impact	0.61	0.8	25.27	18.67	0.57	P	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5921	5921	A	C	MI.1915	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	18	6	W	C	tgA/tgC	6.14	1	0	probably_damaging	1	deleterious	0	deleterious	-1.86	deleterious	-6.93	neutral	-1.76	high_impact	4.03	0.58	damaging	0.07	damaging	4.03	23.60	deleterious	0.28	0.55	0.95	disease	0.79	disease	0.85	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.62	high_impact	0.20	0.9	3.12	6.72	0.51	P	0.88	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12104	12104	C	T	MI.19150	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1345	449	L	F	Ctc/Ttc	-8.72	0	0	possibly_damaging	0.78	neutral	0.29	neutral	2.06	neutral	-2.35	neutral	-2.19	low_impact	1.94	0.74	neutral	0.84	neutral	1.28	12.15	neutral	0.22	0.45	0.62	disease	0.32	neutral	0.17	neutral	0.61	disease	2	0.83	neutral	0.26	neutral	-3	neutral	0.50	deleterious	-1.23	low_impact	-0.02	medium_impact	0.79	medium_impact	0.36	0.8	25.27	18.67	0.45	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12104	12104	C	G	MI.19151	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1345	449	L	V	Ctc/Gtc	-8.72	0	0	benign	0.15	neutral	0.14	neutral	2.18	neutral	-0.45	neutral	-1.15	medium_impact	2.86	0.78	neutral	0.88	neutral	0.57	7.92	deleterious	0.37	0.5	0.56	disease	0.3	neutral	0.34	neutral	0.6	disease	2	0.84	neutral	0.5	deleterious	-3	neutral	0.21	neutral	-0.01	medium_impact	-0.24	medium_impact	1.7	medium_impact	0.63	0.8	25.27	18.67	0.45	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12105	12105	T	G	MI.19152	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1346	449	L	R	cTc/cGc	-4.35	0	0	probably_damaging	0.93	deleterious	0	neutral	1.99	deleterious	-4.17	deleterious	-3.97	high_impact	3.75	0.68	neutral	0.44	neutral	4.04	23.70	deleterious	0.02	0.35	0.71	disease	0.75	disease	0.69	disease	0.73	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.72	deleterious	-1.77	low_impact	-1.48	low_impact	2.58	high_impact	0.10	0.8	25.27	18.67	0.39	N	0.96	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12105	12105	T	C	MI.19153	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1346	449	L	P	cTc/cCc	-4.35	0	0	probably_damaging	0.95	deleterious	0	neutral	1.98	deleterious	-4.71	deleterious	-4.55	high_impact	3.75	0.64	neutral	0.38	neutral	3.81	23.40	deleterious	0.02	0.35	0.9	disease	0.75	disease	0.55	disease	0.75	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-1.92	low_impact	-1.48	low_impact	2.58	high_impact	0.21	0.8	25.27	18.67	0.37	N	0.94	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12105	12105	T	A	MI.19154	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1346	449	L	H	cTc/cAc	-4.35	0	0	probably_damaging	0.95	deleterious	0	neutral	1.98	deleterious	-4.81	deleterious	-4.55	high_impact	3.75	0.74	neutral	0.52	neutral	4.09	23.70	deleterious	0.03	0.35	0.84	disease	0.65	disease	0.63	disease	0.71	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.74	deleterious	-1.92	low_impact	-1.48	low_impact	2.58	high_impact	0.26	0.8	25.27	18.67	0.41	N	0.84	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12107	12107	A	T	MI.19155	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1348	450	N	Y	Aac/Tac	-10.1	0	0	probably_damaging	0.96	neutral	0.07	neutral	2.35	neutral	0.07	deleterious	-5.35	medium_impact	2.34	0.75	neutral	0.17	damaging	3.86	23.50	deleterious	0.15	0.4	0.52	disease	0.64	disease	0.4	neutral	0.49	neutral	0	0.99	deleterious	0.06	neutral	1	deleterious	0.75	deleterious	-2.01	low_impact	-0.43	medium_impact	1.19	medium_impact	0.23	0.8	13.73	8.17	0.34	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12107	12107	A	C	MI.19156	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1348	450	N	H	Aac/Cac	-10.1	0	0	probably_damaging	0.96	deleterious	0.03	neutral	2.27	deleterious	-3.11	deleterious	-3.27	low_impact	1.83	0.8	neutral	0.18	damaging	3.22	22.70	deleterious	0.35	0.5	0.71	disease	0.56	disease	0.6	disease	0.68	disease	4	0.99	deleterious	0.04	neutral	2	deleterious	0.76	deleterious	-2.01	low_impact	-0.64	medium_impact	0.68	medium_impact	0.24	0.8	13.73	8.17	0.27	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12107	12107	A	G	MI.19157	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1348	450	N	D	Aac/Gac	-10.1	0	0	benign	0.05	deleterious	0.03	neutral	2.29	neutral	-2.89	deleterious	-3.21	medium_impact	2.75	0.8	neutral	0.36	neutral	3.88	23.50	deleterious	0.46	0.55	0.56	disease	0.56	disease	0.55	disease	0.59	disease	2	0.97	neutral	0.49	deleterious	1	deleterious	0.73	deleterious	0.48	medium_impact	-0.64	medium_impact	1.6	medium_impact	0.34	0.8	13.73	8.17	0.36	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12108	12108	A	C	MI.19158	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1349	450	N	T	aAc/aCc	8.55	1	0	possibly_damaging	0.78	deleterious	0.02	neutral	2.32	neutral	-0.48	deleterious	-3.8	medium_impact	2.89	0.71	neutral	0.18	damaging	3.96	23.60	deleterious	0.25	0.45	0.28	neutral	0.44	neutral	0.63	disease	0.48	neutral	0	0.99	deleterious	0.12	neutral	4	deleterious	0.68	deleterious	-1.23	low_impact	-0.75	medium_impact	1.73	medium_impact	0.28	0.8	13.73	8.17	0.65	P	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12108	12108	A	G	MI.19159	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1349	450	N	S	aAc/aGc	8.55	1	0	possibly_damaging	0.52	neutral	0.08	neutral	2.33	neutral	1.08	deleterious	-2.86	low_impact	1.57	0.81	neutral	0.86	neutral	2.56	19.83	deleterious	0.44	0.55	0.32	neutral	0.45	neutral	0.35	neutral	0.43	neutral	1	0.91	neutral	0.28	neutral	-3	neutral	0.69	deleterious	-0.75	medium_impact	-0.39	medium_impact	0.43	medium_impact	0.16	0.8	13.73	8.17	0.63	P	0.46	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5921	5921	A	T	MI.1916	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	18	6	W	C	tgA/tgT	6.14	1	0	probably_damaging	1	deleterious	0	deleterious	-1.86	deleterious	-6.93	neutral	-1.76	high_impact	4.03	0.58	damaging	0.07	damaging	4.14	23.80	deleterious	0.28	0.55	0.95	disease	0.79	disease	0.85	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.62	high_impact	0.20	0.9	3.12	6.72	0.52	P	0.88	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12108	12108	A	T	MI.19160	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1349	450	N	I	aAc/aTc	8.55	1	0	probably_damaging	0.92	neutral	0.06	neutral	2.31	neutral	-0.09	deleterious	-6.2	medium_impact	3.09	0.72	neutral	0.18	damaging	4.59	24.40	deleterious	0.16	0.45	0.68	disease	0.73	disease	0.62	disease	0.7	disease	4	0.98	deleterious	0.07	neutral	1	deleterious	0.77	deleterious	-1.71	low_impact	-0.47	medium_impact	1.93	medium_impact	0.20	0.8	13.73	8.17	0.63	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12109	12109	C	A	MI.19161	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1350	450	N	K	aaC/aaA	4.63	1	0	possibly_damaging	0.73	neutral	1	neutral	2.39	neutral	-1.93	neutral	-2.22	neutral_impact	0.72	0.67	neutral	0.8	neutral	1.87	15.40	deleterious	0.39	0.5	0.32	neutral	0.09	neutral	0.27	neutral	0.23	neutral	5	0.73	neutral	0.64	deleterious	-3	neutral	0.66	deleterious	-1.12	low_impact	1.88	high_impact	-0.41	medium_impact	0.32	0.8	13.73	8.17	0.53	P	0.90	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12109	12109	C	G	MI.19162	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1350	450	N	K	aaC/aaG	4.63	1	0	possibly_damaging	0.73	neutral	1	neutral	2.39	neutral	-1.93	neutral	-2.22	neutral_impact	0.72	0.67	neutral	0.8	neutral	1.43	12.93	neutral	0.39	0.5	0.32	neutral	0.09	neutral	0.27	neutral	0.23	neutral	5	0.73	neutral	0.64	deleterious	-3	neutral	0.66	deleterious	-1.12	low_impact	1.88	high_impact	-0.41	medium_impact	0.32	0.8	13.73	8.17	0.53	P	0.90	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12110	12110	C	A	MI.19163	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1351	451	P	T	Ccc/Acc	-4.35	0	0	probably_damaging	1	neutral	0.06	neutral	2.04	deleterious	-3.14	deleterious	-7.17	medium_impact	3.35	0.64	neutral	0.4	neutral	3.99	23.60	deleterious	0.08	0.35	0.63	disease	0.6	disease	0.6	disease	0.58	disease	2	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.47	medium_impact	2.19	high_impact	0.50	0.8	46.62	9.54	0.38	N	0.88	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12110	12110	C	G	MI.19164	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1351	451	P	A	Ccc/Gcc	-4.35	0	0	probably_damaging	1	neutral	0.05	neutral	2.07	neutral	-2.46	deleterious	-7.17	high_impact	4.15	0.65	neutral	0.48	neutral	3.24	22.80	deleterious	0.1	0.4	0.62	disease	0.46	neutral	0.73	disease	0.64	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.75	deleterious	-3.54	low_impact	-0.52	medium_impact	2.98	high_impact	0.65	0.8	46.62	9.54	0.45	N	0.74	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12110	12110	C	T	MI.19165	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1351	451	P	S	Ccc/Tcc	-4.35	0	0	probably_damaging	1	neutral	0.22	neutral	2.06	neutral	-2.64	deleterious	-7.17	medium_impact	3.17	0.65	neutral	0.45	neutral	3.99	23.60	deleterious	0.08	0.35	0.55	disease	0.59	disease	0.56	disease	0.45	neutral	1	1	deleterious	0.11	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.11	medium_impact	2.01	high_impact	0.13	0.8	46.62	9.54	0.35	N	0.68	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12111	12111	C	A	MI.19166	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1352	451	P	H	cCc/cAc	5.32	1	0	probably_damaging	1	deleterious	0.03	neutral	1.99	deleterious	-4.85	deleterious	-8.05	high_impact	3.81	0.65	neutral	0.34	neutral	4.16	23.80	deleterious	0.04	0.35	0.8	disease	0.76	disease	0.8	disease	0.83	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-3.54	low_impact	-0.64	medium_impact	2.64	high_impact	0.23	0.8	46.62	9.54	0.62	P	0.70	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12111	12111	C	G	MI.19167	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1352	451	P	R	cCc/cGc	5.32	1	0	probably_damaging	1	deleterious	0.02	neutral	2.02	deleterious	-3.58	deleterious	-8.06	high_impact	4.15	0.63	neutral	0.42	neutral	3.77	23.40	deleterious	0.03	0.35	0.64	disease	0.79	disease	0.83	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.54	low_impact	-0.75	medium_impact	2.98	high_impact	0.21	0.8	46.62	9.54	0.65	P	0.62	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12111	12111	C	T	MI.19168	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1352	451	P	L	cCc/cTc	5.32	1	0	probably_damaging	1	neutral	0.11	neutral	2.04	deleterious	-3.49	deleterious	-8.96	medium_impact	3.05	0.62	neutral	0.42	neutral	4.55	24.40	deleterious	0.04	0.35	0.78	disease	0.76	disease	0.69	disease	0.71	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.31	medium_impact	1.89	medium_impact	0.52	0.8	46.62	9.54	0.59	P	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12113	12113	G	T	MI.19169	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1354	452	D	Y	Gac/Tac	-10.33	0	0	benign	0.4	neutral	0.06	neutral	2.22	neutral	1.1	neutral	-1.58	low_impact	0.86	0.75	neutral	0.62	neutral	2.31	18.25	deleterious	0.08	0.35	0.47	neutral	0.5	disease	0.57	disease	0.7	disease	4	0.93	neutral	0.33	neutral	-6	neutral	0.42	neutral	-0.55	medium_impact	-0.47	medium_impact	-0.28	medium_impact	0.08	0.8	22	30.03	0.41	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5922	5922	C	G	MI.1917	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	19	7	L	V	Cta/Gta	3.83	0.99	0	possibly_damaging	0.89	deleterious	0.03	neutral	-0.95	neutral	-0.62	neutral	-0.31	medium_impact	2.1	0.65	neutral	0.15	damaging	1.51	13.39	neutral	0.39	0.55	0.3	neutral	0.39	neutral	0.28	neutral	0.46	neutral	1	0.99	deleterious	0.07	neutral	4	deleterious	0.65	deleterious	-1.61	low_impact	-0.65	medium_impact	0.84	medium_impact	0.69	0.9	7.99	10.87	0.53	P	0.64	disease_causing	0.93	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12113	12113	G	A	MI.19170	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1354	452	D	N	Gac/Aac	-10.33	0	0	benign	0	neutral	0.18	neutral	2.3	neutral	0.07	neutral	0.16	neutral_impact	-1.07	0.79	neutral	0.85	neutral	1.18	11.65	neutral	0.72	0.75	0.34	neutral	0.26	neutral	0.17	neutral	0.45	neutral	1	0.82	neutral	0.59	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	-0.17	medium_impact	-2.18	low_impact	0.62	0.8	22	30.03	0.49	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12113	12113	G	C	MI.19171	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1354	452	D	H	Gac/Cac	-10.33	0	0	benign	0.4	deleterious	0.02	neutral	2.24	neutral	-2.09	neutral	-0.42	neutral_impact	0.72	0.74	neutral	0.62	neutral	2.03	16.38	deleterious	0.16	0.45	0.6	disease	0.36	neutral	0.42	neutral	0.61	disease	2	0.98	neutral	0.31	neutral	-2	neutral	0.35	neutral	-0.55	medium_impact	-0.75	medium_impact	-0.41	medium_impact	0.51	0.8	22	30.03	0.43	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12114	12114	A	T	MI.19172	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1355	452	D	V	gAc/gTc	0.95	0	0	benign	0.05	neutral	0.07	neutral	2.24	neutral	-0.09	neutral	-1.75	low_impact	1.42	0.79	neutral	0.7	neutral	2.16	17.27	deleterious	0.05	0.35	0.57	disease	0.47	neutral	0.54	disease	0.65	disease	3	0.93	neutral	0.51	deleterious	-6	neutral	0.23	neutral	0.48	medium_impact	-0.43	medium_impact	0.28	medium_impact	0.12	0.8	22	30.03	0.38	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12114	12114	A	G	MI.19173	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1355	452	D	G	gAc/gGc	0.95	0	0	benign	0.05	neutral	0.16	neutral	2.25	neutral	2.38	neutral	-1.62	neutral_impact	0.06	0.73	neutral	0.75	neutral	2.26	17.90	deleterious	0.14	0.4	0.55	disease	0.34	neutral	0.42	neutral	0.6	disease	2	0.83	neutral	0.56	deleterious	-6	neutral	0.14	neutral	0.48	medium_impact	-0.2	medium_impact	-1.07	low_impact	0.38	0.8	22	30.03	0.43	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12114	12114	A	C	MI.19174	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1355	452	D	A	gAc/gCc	0.95	0	0	benign	0.03	neutral	0.19	neutral	2.32	neutral	0.84	neutral	-0.79	neutral_impact	0	0.67	neutral	0.86	neutral	0.80	9.48	deleterious	0.13	0.4	0.35	neutral	0.23	neutral	0.44	neutral	0.44	neutral	1	0.8	neutral	0.58	deleterious	-6	neutral	0.12	neutral	0.7	medium_impact	-0.15	medium_impact	-1.13	low_impact	0.30	0.8	22	30.03	0.48	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12115	12115	C	A	MI.19175	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1356	452	D	E	gaC/gaA	0.72	0	0	benign	0.05	neutral	1	neutral	2.38	neutral	-0.85	neutral	1.64	neutral_impact	-1.12	0.67	neutral	0.78	neutral	-0.29	0.68	neutral	0.39	0.5	0.28	neutral	0.08	neutral	0.1	neutral	0.26	neutral	5	0.05	neutral	0.98	deleterious	-6	neutral	0.10	neutral	0.48	medium_impact	1.88	high_impact	-2.23	low_impact	0.57	0.8	22	30.03	0.38	N	0.23	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12115	12115	C	G	MI.19176	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1356	452	D	E	gaC/gaG	0.72	0	0	benign	0.05	neutral	1	neutral	2.38	neutral	-0.85	neutral	1.64	neutral_impact	-1.12	0.67	neutral	0.78	neutral	-0.64	0.10	neutral	0.39	0.5	0.28	neutral	0.08	neutral	0.1	neutral	0.26	neutral	5	0.05	neutral	0.98	deleterious	-6	neutral	0.10	neutral	0.48	medium_impact	1.88	high_impact	-2.23	low_impact	0.57	0.8	22	30.03	0.37	N	0.23	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12116	12116	A	T	MI.19177	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1357	453	I	F	Atc/Ttc	-0.89	0	0	possibly_damaging	0.47	neutral	0.27	neutral	2.21	neutral	-0.76	neutral	-2.06	low_impact	1.7	0.75	neutral	0.92	neutral	2.50	19.44	deleterious	0.15	0.4	0.6	disease	0.4	neutral	0.24	neutral	0.62	disease	2	0.7	neutral	0.4	neutral	-3	neutral	0.70	deleterious	-0.67	medium_impact	-0.04	medium_impact	0.56	medium_impact	0.65	0.8	30.94	17.28	0.43	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12116	12116	A	C	MI.19178	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1357	453	I	L	Atc/Ctc	-0.89	0	0	benign	0.01	neutral	1	neutral	2.42	neutral	2.09	neutral	0.17	neutral_impact	0.08	0.67	neutral	0.94	neutral	0.90	10.05	neutral	0.21	0.45	0.29	neutral	0.07	neutral	0.14	neutral	0.23	neutral	5	0.01	neutral	1	deleterious	-6	neutral	0.49	deleterious	1.16	medium_impact	1.88	high_impact	-1.05	low_impact	0.52	0.8	30.94	17.28	0.49	N	0.16	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12116	12116	A	G	MI.19179	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1357	453	I	V	Atc/Gtc	-0.89	0	0	benign	0.01	neutral	0.08	neutral	2.3	neutral	3.09	neutral	-0.78	low_impact	1.02	0.84	neutral	0.96	neutral	1.77	14.79	neutral	0.54	0.6	0.28	neutral	0.14	neutral	0.39	neutral	0.3	neutral	4	0.92	neutral	0.54	deleterious	-6	neutral	0.50	deleterious	1.16	medium_impact	-0.39	medium_impact	-0.12	medium_impact	0.50	0.8	30.94	17.28	0.47	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5922	5922	C	A	MI.1918	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	19	7	L	M	Cta/Ata	3.83	0.99	0	probably_damaging	0.99	neutral	0.05	neutral	-0.97	neutral	-2.63	neutral	-0.19	medium_impact	2.34	0.64	neutral	0.27	damaging	0.91	10.13	neutral	0.3	0.55	0.39	neutral	0.31	neutral	0.26	neutral	0.47	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.69	deleterious	-2.64	low_impact	-0.52	medium_impact	1.06	medium_impact	0.72	0.9	7.99	10.87	0.58	P	0.55	disease_causing	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12117	12117	T	A	MI.19180	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1358	453	I	N	aTc/aAc	-0.2	0	0	possibly_damaging	0.64	deleterious	0.01	neutral	2.15	neutral	1.55	deleterious	-4.91	medium_impact	2.9	0.66	neutral	0.54	neutral	4.59	24.40	deleterious	0.17	0.45	0.38	neutral	0.57	disease	0.59	disease	0.71	disease	4	0.99	deleterious	0.19	neutral	4	deleterious	0.73	deleterious	-0.95	medium_impact	-0.92	medium_impact	1.74	medium_impact	0.13	0.8	30.94	17.28	0.4	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12117	12117	T	C	MI.19181	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1358	453	I	T	aTc/aCc	-0.2	0	0	benign	0.02	deleterious	0.04	neutral	2.21	neutral	1.57	deleterious	-3.12	low_impact	1.86	0.79	neutral	0.85	neutral	3.45	23.00	deleterious	0.17	0.45	0.5	neutral	0.25	neutral	0.46	neutral	0.42	neutral	2	0.96	neutral	0.51	deleterious	-2	neutral	0.69	deleterious	0.87	medium_impact	-0.57	medium_impact	0.71	medium_impact	0.31	0.8	30.94	17.28	0.42	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12117	12117	T	G	MI.19182	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1358	453	I	S	aTc/aGc	-0.2	0	0	benign	0.24	deleterious	0.03	neutral	2.19	neutral	3.34	deleterious	-4.02	low_impact	1.7	0.7	neutral	0.59	neutral	4.40	24.10	deleterious	0.06	0.35	0.45	neutral	0.5	neutral	0.59	disease	0.65	disease	3	0.97	neutral	0.4	neutral	-2	neutral	0.71	deleterious	-0.25	medium_impact	-0.64	medium_impact	0.56	medium_impact	0.21	0.8	30.94	17.28	0.37	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12118	12118	C	G	MI.19183	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1359	453	I	M	atC/atG	3.71	0.52	0	possibly_damaging	0.55	neutral	0.09	neutral	2.19	neutral	-0.33	neutral	-0.97	low_impact	1.23	0.81	neutral	0.97	neutral	3.70	23.30	deleterious	0.33	0.5	0.24	neutral	0.22	neutral	0.23	neutral	0.41	neutral	2	0.91	neutral	0.27	neutral	-3	neutral	0.66	deleterious	-0.8	medium_impact	-0.36	medium_impact	0.09	medium_impact	0.62	0.8	30.94	17.28	0.46	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12118	12118	C	A	MI.19184	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1359	453	I	M	atC/atA	3.71	0.52	0	possibly_damaging	0.55	neutral	0.09	neutral	2.19	neutral	-0.33	neutral	-0.97	low_impact	1.23	0.81	neutral	0.97	neutral	4.23	23.90	deleterious	0.33	0.5	0.24	neutral	0.22	neutral	0.23	neutral	0.41	neutral	2	0.91	neutral	0.27	neutral	-3	neutral	0.66	deleterious	-0.8	medium_impact	-0.36	medium_impact	0.09	medium_impact	0.62	0.8	30.94	17.28	0.46	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12119	12119	A	G	MI.19185	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1360	454	I	V	Att/Gtt	-7.11	0	0	probably_damaging	0.99	neutral	0.18	neutral	2.27	neutral	-0.27	neutral	-0.75	low_impact	1.61	0.73	neutral	0.87	neutral	2.11	16.94	deleterious	0.61	0.65	0.41	neutral	0.11	neutral	0.33	neutral	0.31	neutral	4	0.99	deleterious	0.1	neutral	-2	neutral	0.51	deleterious	-2.59	low_impact	-0.17	medium_impact	0.47	medium_impact	0.44	0.8	45.32	10.07	0.48	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12119	12119	A	C	MI.19186	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1360	454	I	L	Att/Ctt	-7.11	0	0	probably_damaging	0.99	neutral	0.28	neutral	2.24	neutral	-1.54	neutral	-1.42	low_impact	1.78	0.64	neutral	0.31	neutral	3.92	23.50	deleterious	0.28	0.45	0.25	neutral	0.31	neutral	0.31	neutral	0.43	neutral	1	0.99	deleterious	0.15	neutral	-2	neutral	0.52	deleterious	-2.59	low_impact	-0.03	medium_impact	0.64	medium_impact	0.67	0.85	45.32	10.07	0.38	N	0.85	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12119	12119	A	T	MI.19187	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1360	454	I	F	Att/Ttt	-7.11	0	0	probably_damaging	1	neutral	0.33	neutral	2.07	neutral	-2.89	deleterious	-3.23	medium_impact	2.69	0.68	neutral	0.18	damaging	4.08	23.70	deleterious	0.17	0.45	0.59	disease	0.47	neutral	0.51	disease	0.58	disease	2	1	deleterious	0.17	neutral	1	deleterious	0.70	deleterious	-3.54	low_impact	0.03	medium_impact	1.54	medium_impact	0.66	0.8	45.32	10.07	0.29	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12120	12120	T	A	MI.19188	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1361	454	I	N	aTt/aAt	1.87	0.88	0	probably_damaging	1	deleterious	0.02	neutral	2	neutral	0.03	deleterious	-5.78	medium_impact	3.38	0.56	damaging	0.17	damaging	4.78	24.70	deleterious	0.08	0.35	0.75	disease	0.63	disease	0.7	disease	0.69	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.54	low_impact	-0.75	medium_impact	2.22	high_impact	0.08	0.8	45.32	10.07	0.38	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12120	12120	T	C	MI.19189	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1361	454	I	T	aTt/aCt	1.87	0.88	0	probably_damaging	1	deleterious	0.02	neutral	2.05	neutral	-0.56	deleterious	-4.06	medium_impact	2.75	0.76	neutral	0.28	damaging	3.68	23.30	deleterious	0.07	0.35	0.25	neutral	0.4	neutral	0.6	disease	0.45	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.67	deleterious	-3.54	low_impact	-0.75	medium_impact	1.6	medium_impact	0.19	0.8	45.32	10.07	0.4	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5923	5923	T	A	MI.1919	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	20	7	L	Q	cTa/cAa	-1.49	0	0	probably_damaging	0.99	deleterious	0	neutral	-1.01	deleterious	-3.8	neutral	-0.72	high_impact	3.75	0.64	neutral	0.13	damaging	3.98	23.60	deleterious	0.18	0.55	0.7	disease	0.72	disease	0.6	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	2.36	high_impact	0.60	0.9	7.99	10.87	0.37	N	0.84	disease_causing	0.83	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12120	12120	T	G	MI.19190	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1361	454	I	S	aTt/aGt	1.87	0.88	0	probably_damaging	1	neutral	0.06	neutral	2.02	neutral	-2.06	deleterious	-4.88	medium_impact	3.04	0.6	damaging	0.16	damaging	4.58	24.40	deleterious	0.02	0.35	0.62	disease	0.64	disease	0.7	disease	0.71	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.47	medium_impact	1.88	medium_impact	0.10	0.8	45.32	10.07	0.37	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12121	12121	T	G	MI.19191	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1362	454	I	M	atT/atG	5.55	0.98	0	probably_damaging	1	neutral	0.27	neutral	2.06	neutral	-2.91	neutral	-1.91	low_impact	1.5	0.72	neutral	0.43	neutral	2.27	17.98	deleterious	0.27	0.45	0.46	neutral	0.21	neutral	0.33	neutral	0.37	neutral	3	1	deleterious	0.14	neutral	-2	neutral	0.67	deleterious	-3.54	low_impact	-0.04	medium_impact	0.36	medium_impact	0.51	0.8	45.32	10.07	0.67	P	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12121	12121	T	A	MI.19192	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1362	454	I	M	atT/atA	5.55	0.98	0	probably_damaging	1	neutral	0.27	neutral	2.06	neutral	-2.91	neutral	-1.91	low_impact	1.5	0.72	neutral	0.43	neutral	2.56	19.87	deleterious	0.27	0.45	0.46	neutral	0.21	neutral	0.33	neutral	0.37	neutral	3	1	deleterious	0.14	neutral	-2	neutral	0.67	deleterious	-3.54	low_impact	-0.04	medium_impact	0.36	medium_impact	0.51	0.8	45.32	10.07	0.67	P	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12122	12122	A	C	MI.19193	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1363	455	T	P	Acc/Ccc	-5.5	0	0	benign	0.23	neutral	0.2	neutral	2.22	neutral	-2.31	neutral	-1.7	low_impact	1.79	0.62	neutral	0.54	neutral	2.09	16.77	deleterious	0.06	0.35	0.88	disease	0.41	neutral	0.36	neutral	0.66	disease	3	0.76	neutral	0.49	deleterious	-6	neutral	0.58	deleterious	-0.23	medium_impact	-0.14	medium_impact	0.65	medium_impact	0.36	0.8	26.36	24.05	0.37	N	0.72	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12122	12122	A	T	MI.19194	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1363	455	T	S	Acc/Tcc	-5.5	0	0	benign	0.05	neutral	0.83	neutral	2.3	neutral	-0.59	neutral	-0.57	neutral_impact	-0.24	0.67	neutral	0.89	neutral	0.50	7.40	deleterious	0.4	0.5	0.63	disease	0.03	neutral	0.15	neutral	0.33	neutral	3	0.09	neutral	0.89	deleterious	-6	neutral	0.20	neutral	0.48	medium_impact	0.59	medium_impact	-1.36	low_impact	0.50	0.8	26.36	24.05	0.4	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12122	12122	A	G	MI.19195	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1363	455	T	A	Acc/Gcc	-5.5	0	0	benign	0	neutral	0.5	neutral	2.32	neutral	-0.17	neutral	-0.36	low_impact	0.98	0.75	neutral	0.82	neutral	1.87	15.41	deleterious	0.36	0.5	0.67	disease	0.08	neutral	0.36	neutral	0.38	neutral	2	0.5	neutral	0.75	deleterious	-6	neutral	0.17	neutral	2.1	high_impact	0.2	medium_impact	-0.16	medium_impact	0.52	0.8	26.36	24.05	0.43	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12123	12123	C	T	MI.19196	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1364	455	T	I	aCc/aTc	-0.43	0	0	benign	0.03	neutral	0.44	neutral	2.32	neutral	-0.35	neutral	1.09	neutral_impact	0.2	0.76	neutral	0.61	neutral	2.38	18.66	deleterious	0.16	0.45	0.71	disease	0.18	neutral	0.38	neutral	0.47	neutral	1	0.53	neutral	0.71	deleterious	-6	neutral	0.33	neutral	0.7	medium_impact	0.14	medium_impact	-0.93	medium_impact	0.62	0.8	26.36	24.05	0.37	N	0.23	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12123	12123	C	A	MI.19197	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1364	455	T	N	aCc/aAc	-0.43	0	0	benign	0.23	neutral	0.3	neutral	2.25	neutral	-1.34	neutral	-1.58	low_impact	1.79	0.71	neutral	0.61	neutral	2.16	17.27	deleterious	0.35	0.5	0.8	disease	0.22	neutral	0.38	neutral	0.51	disease	0	0.64	neutral	0.54	deleterious	-6	neutral	0.43	neutral	-0.23	medium_impact	0	medium_impact	0.65	medium_impact	0.49	0.8	26.36	24.05	0.4	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12123	12123	C	G	MI.19198	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1364	455	T	S	aCc/aGc	-0.43	0	0	benign	0.05	neutral	0.83	neutral	2.3	neutral	-0.59	neutral	-0.57	neutral_impact	-0.24	0.67	neutral	0.89	neutral	0.68	8.69	deleterious	0.4	0.5	0.63	disease	0.03	neutral	0.15	neutral	0.33	neutral	3	0.09	neutral	0.89	deleterious	-6	neutral	0.20	neutral	0.48	medium_impact	0.59	medium_impact	-1.36	low_impact	0.50	0.8	26.36	24.05	0.4	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12125	12125	G	C	MI.19199	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1366	456	G	R	Ggg/Cgg	-1.58	0	0	probably_damaging	1	neutral	0.11	neutral	2.26	neutral	-0.24	deleterious	-6.39	medium_impact	3.08	0.68	neutral	0.38	neutral	4.30	24.00	deleterious	0.17	0.45	0.38	neutral	0.58	disease	0.7	disease	0.69	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-3.54	low_impact	-0.31	medium_impact	1.92	medium_impact	0.80	0.85	NA	NA	0.38	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8617	8617	A	C	MI.192	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	91	31	I	L	Atc/Ctc	-2.65	0	0	benign	0.01	neutral	0.81	neutral	4.47	neutral	0.37	neutral	-0.18	neutral_impact	-0.26	0.87	neutral	0.93	neutral	0.17	4.32	deleterious	0.44	0.65	0.35	neutral	0.28	neutral	0.13	neutral	0.46	neutral	1	0.16	neutral	0.9	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.65	medium_impact	-1.32	low_impact	0.40	0.9	28.32	22.32	0.36	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5923	5923	T	C	MI.1920	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	20	7	L	P	cTa/cCa	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	-1.01	deleterious	-4.29	neutral	-0.86	medium_impact	3.4	0.53	damaging	0.11	damaging	3.85	23.40	deleterious	0.15	0.55	0.75	disease	0.79	disease	0.6	disease	0.71	disease	4	1	deleterious	0	neutral	5	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.04	high_impact	0.41	0.9	7.99	10.87	0.3	N	0.86	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12125	12125	G	T	MI.19200	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1366	456	G	W	Ggg/Tgg	-1.58	0	0	probably_damaging	1	neutral	0.06	neutral	2.19	deleterious	-3.39	deleterious	-5.97	medium_impact	3.43	0.67	neutral	0.35	neutral	4.75	24.70	deleterious	0.12	0.4	0.87	disease	0.58	disease	0.69	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.81	deleterious	-3.54	low_impact	-0.47	medium_impact	2.27	high_impact	0.11	0.8	NA	NA	0.34	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12126	12126	G	C	MI.19201	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1367	456	G	A	gGg/gCg	5.32	1	0	probably_damaging	1	neutral	0.16	neutral	2.31	neutral	0.35	deleterious	-4.81	medium_impact	3.43	0.72	neutral	0.51	neutral	3.48	23.10	deleterious	0.33	0.5	0.42	neutral	0.29	neutral	0.52	disease	0.42	neutral	2	1	deleterious	0.08	neutral	1	deleterious	0.72	deleterious	-3.54	low_impact	-0.2	medium_impact	2.27	high_impact	0.46	0.8	NA	NA	0.68	P	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12126	12126	G	A	MI.19202	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1367	456	G	E	gGg/gAg	5.32	1	0	probably_damaging	1	neutral	0.11	neutral	2.31	neutral	0.51	deleterious	-6.45	medium_impact	3.08	0.71	neutral	0.41	neutral	4.20	23.90	deleterious	0.2	0.45	0.52	disease	0.56	disease	0.68	disease	0.68	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.78	deleterious	-3.54	low_impact	-0.31	medium_impact	1.92	medium_impact	0.39	0.8	NA	NA	0.62	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12126	12126	G	T	MI.19203	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1367	456	G	V	gGg/gTg	5.32	1	0	probably_damaging	1	neutral	0.19	neutral	2.26	neutral	-0.46	deleterious	-6.29	medium_impact	3.43	0.69	neutral	0.45	neutral	4.11	23.70	deleterious	0.07	0.35	0.41	neutral	0.55	disease	0.65	disease	0.67	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.75	deleterious	-3.54	low_impact	-0.15	medium_impact	2.27	high_impact	0.09	0.8	NA	NA	0.63	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12128	12128	T	C	MI.19204	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1369	457	F	L	Ttt/Ctt	-20	0	0	benign	0	neutral	0.07	neutral	2.43	neutral	0.82	neutral	-0.02	neutral_impact	0.31	0.86	neutral	0.96	neutral	0.87	9.92	deleterious	0.32	0.5	NA	NA	0.07	neutral	0.26	neutral	0.21	neutral	6	0.93	neutral	0.54	deleterious	-6	neutral	0.08	neutral	2.1	high_impact	-0.43	medium_impact	-0.82	medium_impact	0.52	0.8	29.41	29.87	0.54	P	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12128	12128	T	A	MI.19205	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1369	457	F	I	Ttt/Att	-20	0	0	benign	0.09	neutral	0.06	neutral	2.33	neutral	-0.17	neutral	-0.38	low_impact	1.14	0.78	neutral	0.98	neutral	1.68	14.31	neutral	0.32	0.5	NA	NA	0.1	neutral	0.31	neutral	0.23	neutral	6	0.93	neutral	0.49	deleterious	-6	neutral	0.12	neutral	0.23	medium_impact	-0.47	medium_impact	0	medium_impact	0.45	0.8	29.41	29.87	0.46	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12128	12128	T	G	MI.19206	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1369	457	F	V	Ttt/Gtt	-20	0	0	benign	0.15	deleterious	0	neutral	2.33	neutral	-0.11	neutral	-0.31	low_impact	1.63	0.81	neutral	0.91	neutral	2.43	19.04	deleterious	0.25	0.45	NA	NA	0.19	neutral	0.6	disease	0.3	neutral	4	1	deleterious	0.43	neutral	-2	neutral	0.12	neutral	-0.01	medium_impact	-1.48	low_impact	0.49	medium_impact	0.44	0.8	29.41	29.87	0.43	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12129	12129	T	G	MI.19207	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1370	457	F	C	tTt/tGt	-3.65	0	0	possibly_damaging	0.86	deleterious	0	neutral	2.21	neutral	-2.98	neutral	-0.93	medium_impact	2.17	0.67	neutral	0.67	neutral	3.99	23.60	deleterious	0.12	0.4	NA	NA	0.26	neutral	0.61	disease	0.29	neutral	4	1	deleterious	0.07	neutral	4	deleterious	0.55	deleterious	-1.46	low_impact	-1.48	low_impact	1.02	medium_impact	0.23	0.8	29.41	29.87	0.46	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12129	12129	T	A	MI.19208	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1370	457	F	Y	tTt/tAt	-3.65	0	0	benign	0.43	deleterious	0	neutral	2.28	neutral	-0.55	neutral	0.24	low_impact	1.38	0.82	neutral	0.92	neutral	2.56	19.83	deleterious	0.24	0.45	NA	NA	0.1	neutral	0.28	neutral	0.22	neutral	6	1	deleterious	0.29	neutral	-2	neutral	0.25	neutral	-0.6	medium_impact	-1.48	low_impact	0.24	medium_impact	0.43	0.8	29.41	29.87	0.5	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12129	12129	T	C	MI.19209	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1370	457	F	S	tTt/tCt	-3.65	0	0	possibly_damaging	0.56	deleterious	0	neutral	2.27	neutral	-1.12	neutral	-0.66	low_impact	1.49	0.7	neutral	0.72	neutral	2.68	20.70	deleterious	0.13	0.4	NA	NA	0.19	neutral	0.57	disease	0.32	neutral	4	1	deleterious	0.22	neutral	1	deleterious	0.30	neutral	-0.82	medium_impact	-1.48	low_impact	0.35	medium_impact	0.20	0.8	29.41	29.87	0.45	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	COSM6188324	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5923	5923	T	G	MI.1921	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	20	7	L	R	cTa/cGa	-1.49	0	0	probably_damaging	0.99	deleterious	0	neutral	-1.01	deleterious	-3.61	neutral	-0.73	medium_impact	2.94	0.57	damaging	0.11	damaging	3.81	23.40	deleterious	0.17	0.55	0.68	disease	0.84	disease	0.71	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.86	deleterious	-2.64	low_impact	-1.48	low_impact	1.62	medium_impact	0.66	0.9	7.99	10.87	0.28	N	0.88	disease_causing	0.85	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12130	12130	T	A	MI.19210	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1371	457	F	L	ttT/ttA	-1.35	0	0	benign	0	neutral	0.07	neutral	2.43	neutral	0.82	neutral	-0.02	neutral_impact	0.31	0.86	neutral	0.96	neutral	1.11	11.25	neutral	0.32	0.5	NA	NA	0.07	neutral	0.26	neutral	0.21	neutral	6	0.93	neutral	0.54	deleterious	-6	neutral	0.08	neutral	2.1	high_impact	-0.43	medium_impact	-0.82	medium_impact	0.52	0.8	29.41	29.87	0.54	P	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12130	12130	T	G	MI.19211	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1371	457	F	L	ttT/ttG	-1.35	0	0	benign	0	neutral	0.07	neutral	2.43	neutral	0.82	neutral	-0.02	neutral_impact	0.31	0.86	neutral	0.96	neutral	0.99	10.62	neutral	0.32	0.5	NA	NA	0.07	neutral	0.26	neutral	0.21	neutral	6	0.93	neutral	0.54	deleterious	-6	neutral	0.08	neutral	2.1	high_impact	-0.43	medium_impact	-0.82	medium_impact	0.52	0.8	29.41	29.87	0.54	P	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12131	12131	T	A	MI.19212	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1372	458	S	T	Tcc/Acc	-10.33	0	0	benign	0	neutral	0.74	neutral	2.28	neutral	-0.6	neutral	1.59	neutral_impact	-1.34	0.9	neutral	0.99	neutral	-0.75	0.05	neutral	0.45	0.55	NA	NA	0.01	neutral	0.15	neutral	0.11	neutral	8	0.26	neutral	0.87	deleterious	-6	neutral	0.03	neutral	2.1	high_impact	0.46	medium_impact	-2.45	low_impact	0.41	0.8	26.14	26.85	0.38	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12131	12131	T	G	MI.19213	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1372	458	S	A	Tcc/Gcc	-10.33	0	0	benign	0	neutral	0.4	neutral	2.33	neutral	0	neutral	-0.26	low_impact	1.15	0.86	neutral	0.88	neutral	0.68	8.66	deleterious	0.46	0.55	NA	NA	0.02	neutral	0.24	neutral	0.11	neutral	8	0.6	neutral	0.7	deleterious	-6	neutral	0.04	neutral	2.1	high_impact	0.1	medium_impact	0.01	medium_impact	0.20	0.8	26.14	26.85	0.47	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12131	12131	T	C	MI.19214	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1372	458	S	P	Tcc/Ccc	-10.33	0	0	benign	0.05	neutral	0.29	neutral	2.2	neutral	-2.14	neutral	-0.72	low_impact	1.15	0.77	neutral	0.7	neutral	2.18	17.36	deleterious	0.22	0.45	NA	NA	0.25	neutral	0.28	neutral	0.17	neutral	7	0.69	neutral	0.62	deleterious	-6	neutral	0.12	neutral	0.48	medium_impact	-0.02	medium_impact	0.01	medium_impact	0.18	0.8	26.14	26.85	0.49	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12132	12132	C	T	MI.19215	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1373	458	S	F	tCc/tTc	-2.04	0	0	benign	0.11	neutral	0.13	neutral	2.2	neutral	-2.23	neutral	-0.7	neutral_impact	-0.84	0.82	neutral	0.72	neutral	2.46	19.22	deleterious	0.22	0.45	NA	NA	0.13	neutral	0.35	neutral	0.15	neutral	7	0.85	neutral	0.51	deleterious	-6	neutral	0.14	neutral	0.14	medium_impact	-0.26	medium_impact	-1.96	low_impact	0.13	0.8	26.14	26.85	0.41	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12132	12132	C	A	MI.19216	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1373	458	S	Y	tCc/tAc	-2.04	0	0	benign	0.17	neutral	0.11	neutral	2.19	neutral	-2.41	neutral	-0.26	neutral_impact	0.46	0.77	neutral	0.74	neutral	2.32	18.28	deleterious	0.23	0.45	NA	NA	0.15	neutral	0.34	neutral	0.18	neutral	6	0.87	neutral	0.47	deleterious	-6	neutral	0.14	neutral	-0.07	medium_impact	-0.31	medium_impact	-0.67	medium_impact	0.15	0.8	26.14	26.85	0.46	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12132	12132	C	G	MI.19217	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1373	458	S	C	tCc/tGc	-2.04	0	0	benign	0.22	neutral	1	neutral	2.18	neutral	-2.76	neutral	-0.02	neutral_impact	0.26	0.8	neutral	0.89	neutral	0.78	9.33	deleterious	0.23	0.45	NA	NA	0.04	neutral	0.25	neutral	0.13	neutral	8	0.22	neutral	0.89	deleterious	-6	neutral	0.13	neutral	-0.2	medium_impact	1.88	high_impact	-0.87	medium_impact	0.18	0.8	26.14	26.85	0.28	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12134	12134	T	C	MI.19218	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1375	459	S	P	Tct/Cct	-4.58	0	0	benign	0.34	deleterious	0.04	neutral	2.23	neutral	-1.38	neutral	-0.15	neutral_impact	0.24	0.63	neutral	0.69	neutral	2.42	18.92	deleterious	0.25	0.45	NA	NA	0.31	neutral	0.55	disease	0.26	neutral	5	0.95	neutral	0.35	neutral	-2	neutral	0.50	deleterious	-0.45	medium_impact	-0.57	medium_impact	-0.89	medium_impact	0.29	0.8	NA	NA	0.38	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12134	12134	T	G	MI.19219	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1375	459	S	A	Tct/Gct	-4.58	0	0	benign	0	neutral	1	neutral	2.33	neutral	0.17	neutral	0.01	low_impact	1.29	0.87	neutral	0.96	neutral	-0.01	2.53	deleterious	0.49	0.55	NA	NA	0.01	neutral	0.23	neutral	0.12	neutral	8	0	neutral	1	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	1.88	high_impact	0.15	medium_impact	0.34	0.8	NA	NA	0.36	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5925	5925	T	A	MI.1922	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	22	8	F	I	Ttc/Atc	-2.42	0	0	benign	0.3	deleterious	0.01	neutral	-1.04	neutral	-1.23	neutral	-0.64	medium_impact	2.96	0.66	neutral	0.54	neutral	4.22	23.90	deleterious	0.23	0.55	0.27	neutral	0.77	disease	0.61	disease	0.7	disease	4	0.99	deleterious	0.36	neutral	1	deleterious	0.45	deleterious	-0.41	medium_impact	-0.92	medium_impact	1.63	medium_impact	0.43	0.9	5.85	21.28	0.39	N	0.87	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12134	12134	T	A	MI.19220	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1375	459	S	T	Tct/Act	-4.58	0	0	benign	0.01	neutral	0.5	neutral	2.28	neutral	-0.49	neutral	0.1	neutral_impact	0.56	0.9	neutral	0.81	neutral	0.70	8.82	deleterious	0.49	0.55	NA	NA	0.06	neutral	0.26	neutral	0.12	neutral	8	0.49	neutral	0.75	deleterious	-6	neutral	0.19	neutral	1.16	medium_impact	0.2	medium_impact	-0.57	medium_impact	0.66	0.8	NA	NA	0.47	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12135	12135	C	G	MI.19221	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1376	459	S	C	tCt/tGt	-0.43	0	0.01	possibly_damaging	0.63	neutral	0.07	neutral	2.21	neutral	-2.25	neutral	0.13	low_impact	1.84	0.71	neutral	0.74	neutral	3.54	23.10	deleterious	0.24	0.45	NA	NA	0.18	neutral	0.36	neutral	0.23	neutral	5	0.93	neutral	0.22	neutral	-3	neutral	0.73	deleterious	-0.94	medium_impact	-0.43	medium_impact	0.69	medium_impact	0.26	0.8	NA	NA	0.53	P	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12135	12135	C	A	MI.19222	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1376	459	S	Y	tCt/tAt	-0.43	0	0.01	possibly_damaging	0.63	deleterious	0.01	neutral	2.24	neutral	-1.34	neutral	3.76	neutral_impact	0.6	0.74	neutral	0.78	neutral	3.91	23.50	deleterious	0.25	0.45	NA	NA	0.23	neutral	0.57	disease	0.27	neutral	5	0.99	deleterious	0.19	neutral	1	deleterious	0.70	deleterious	-0.94	medium_impact	-0.92	medium_impact	-0.53	medium_impact	0.25	0.8	NA	NA	0.44	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12135	12135	C	T	MI.19223	MT-ND4	I	ENSG00000198886	ENSP00000354961	ENST00000361381	NU4M_HUMAN	P03905	4538	YP_003024035.1	1376	459	S	F	tCt/tTt	-0.43	0	0.01	possibly_damaging	0.54	deleterious	0.01	neutral	2.24	neutral	-1.1	neutral	2.62	low_impact	0.87	0.7	neutral	0.74	neutral	3.93	23.50	deleterious	0.23	0.45	NA	NA	0.26	neutral	0.57	disease	0.26	neutral	5	0.99	deleterious	0.24	neutral	1	deleterious	0.57	deleterious	-0.78	medium_impact	-0.92	medium_impact	-0.27	medium_impact	0.17	0.8	NA	NA	0.44	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12337	12337	A	T	MI.19224	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1	1	M	L	Ata/Tta	0.95	0.99	0	unknown	NA	deleterious	0	neutral	3.94	neutral	1.02	neutral	-1.98	NA	NA	0.83	neutral	0.52	neutral	0.25	5.24	deleterious	0.29	0.45	NA	NA	0.09	neutral	0.3	neutral	0.11	neutral	8	1	deleterious	0.5	deleterious	2	deleterious	0.44	deleterious	NA	NA	NA	NA	NA	NA	0.49	0.8	17.08	13.19	0.51	P	0.57	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12337	12337	A	C	MI.19225	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1	1	M	L	Ata/Cta	0.95	0.99	0	unknown	NA	deleterious	0	neutral	3.94	neutral	1.02	neutral	-1.98	NA	NA	0.83	neutral	0.52	neutral	0.17	4.32	deleterious	0.29	0.45	NA	NA	0.09	neutral	0.3	neutral	0.11	neutral	8	1	deleterious	0.5	deleterious	2	deleterious	0.44	deleterious	NA	NA	NA	NA	NA	NA	0.49	0.8	17.08	13.19	0.51	P	0.57	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12337	12337	A	G	MI.19226	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1	1	M	V	Ata/Gta	0.95	0.99	0	unknown	NA	deleterious	0	neutral	3.87	neutral	0.46	deleterious	-2.57	NA	NA	0.82	neutral	0.35	neutral	0.86	9.83	deleterious	0.42	0.5	NA	NA	0.1	neutral	0.48	neutral	0.13	neutral	7	1	deleterious	0.5	deleterious	2	deleterious	0.43	neutral	NA	NA	NA	NA	NA	NA	0.39	0.8	17.08	13.19	0.47	N	0.55	NA	NA	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12338	12338	T	C	MI.19227	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	2	1	M	T	aTa/aCa	2.33	0.99	0.02	unknown	NA	deleterious	0	neutral	3.78	neutral	-0.75	deleterious	-3.8	NA	NA	0.75	neutral	0.27	damaging	1.10	11.23	neutral	0.38	0.5	NA	NA	0.19	neutral	0.32	neutral	0.27	neutral	5	1	deleterious	0.5	deleterious	2	deleterious	0.49	deleterious	NA	NA	NA	NA	NA	NA	0.28	0.8	17.08	13.19	0.61	P	0.78	NA	NA	0.07	rs201863060	Pathogenic	Leber's_optic_atrophy	38954	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	T12338C	DEAF1555 increased penetrance / LHON	+	-	Conflicting reports	8	P	N	P,N	damaging
chrM	12338	12338	T	A	MI.19228	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	2	1	M	K	aTa/aAa	2.33	0.99	0.02	unknown	NA	deleterious	0	neutral	3.79	neutral	-0.7	deleterious	-3.91	NA	NA	0.74	neutral	0.29	neutral	2.17	17.30	deleterious	0.21	0.45	NA	NA	0.24	neutral	0.54	disease	0.26	neutral	5	1	deleterious	0.5	deleterious	2	deleterious	0.52	deleterious	NA	NA	NA	NA	NA	NA	0.42	0.8	17.08	13.19	0.49	N	0.90	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12339	12339	A	T	MI.19229	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	3	1	M	I	atA/atT	1.64	0.96	0	unknown	NA	deleterious	0	neutral	3.86	neutral	0.35	deleterious	-2.56	NA	NA	0.91	neutral	0.51	neutral	0.45	7.04	deleterious	0.35	0.5	NA	NA	0.11	neutral	0.28	neutral	0.15	neutral	7	1	deleterious	0.5	deleterious	2	deleterious	0.44	deleterious	NA	NA	NA	NA	NA	NA	0.52	0.8	17.08	13.19	0.5	P	0.18	NA	NA	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5925	5925	T	C	MI.1923	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	22	8	F	L	Ttc/Ctc	-2.42	0	0	benign	0.21	deleterious	0.03	neutral	-1.01	neutral	-0.57	neutral	-0.61	medium_impact	2.06	0.64	neutral	0.51	neutral	3.79	23.40	deleterious	0.29	0.55	0.24	neutral	0.64	disease	0.38	neutral	0.48	neutral	0	0.97	neutral	0.41	neutral	1	deleterious	0.29	neutral	-0.22	medium_impact	-0.65	medium_impact	0.8	medium_impact	0.48	0.9	5.85	21.28	0.45	N	0.81	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12339	12339	A	C	MI.19230	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	3	1	M	I	atA/atC	1.64	0.96	0	unknown	NA	deleterious	0	neutral	3.86	neutral	0.35	deleterious	-2.56	NA	NA	0.91	neutral	0.51	neutral	0.42	6.76	deleterious	0.35	0.5	NA	NA	0.11	neutral	0.28	neutral	0.15	neutral	7	1	deleterious	0.5	deleterious	2	deleterious	0.44	deleterious	NA	NA	NA	NA	NA	NA	0.52	0.8	17.08	13.19	0.5	P	0.18	NA	NA	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12340	12340	A	C	MI.19231	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	4	2	T	P	Acc/Ccc	-0.2	0	0	unknown	NA	neutral	0.21	neutral	3.71	neutral	-1.87	neutral	-1.42	low_impact	0.9	0.66	neutral	0.72	neutral	0.50	7.45	deleterious	0.29	0.45	NA	NA	0.25	neutral	0.23	neutral	0.25	neutral	5	0.79	neutral	0.61	deleterious	-4	neutral	0.23	neutral	2.1	high_impact	-0.09	medium_impact	-0.38	medium_impact	0.55	0.8	28.03	39.33	0.46	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12340	12340	A	T	MI.19232	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	4	2	T	S	Acc/Tcc	-0.2	0	0	unknown	NA	neutral	0.41	neutral	3.8	neutral	-0.01	neutral	0.64	low_impact	0.9	0.81	neutral	0.84	neutral	0.17	4.39	deleterious	0.4	0.5	NA	NA	0.05	neutral	0.08	neutral	0.08	neutral	8	0.59	neutral	0.71	deleterious	-4	neutral	0.12	neutral	2.1	high_impact	0.15	medium_impact	-0.38	medium_impact	0.66	0.8	28.03	39.33	0.5	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12340	12340	A	G	MI.19233	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	4	2	T	A	Acc/Gcc	-0.2	0	0	unknown	NA	neutral	0.51	neutral	3.83	neutral	0.2	neutral	-1.46	low_impact	0.9	0.85	neutral	0.85	neutral	0.36	6.25	deleterious	0.51	0.6	NA	NA	0.04	neutral	0.11	neutral	0.08	neutral	8	0.49	neutral	0.76	deleterious	-4	neutral	0.11	neutral	2.1	high_impact	0.24	medium_impact	-0.38	medium_impact	0.34	0.8	28.03	39.33	0.4	N	0.40	polymorphism	1	0.03	rs28490236	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12341	12341	C	G	MI.19234	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	5	2	T	S	aCc/aGc	-0.2	0	0	unknown	NA	neutral	0.41	neutral	3.8	neutral	-0.01	neutral	0.64	low_impact	0.9	0.81	neutral	0.84	neutral	0.37	6.35	deleterious	0.4	0.5	NA	NA	0.05	neutral	0.08	neutral	0.08	neutral	8	0.59	neutral	0.71	deleterious	-4	neutral	0.12	neutral	2.1	high_impact	0.15	medium_impact	-0.38	medium_impact	0.66	0.8	28.03	39.33	0.51	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12341	12341	C	A	MI.19235	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	5	2	T	N	aCc/aAc	-0.2	0	0	unknown	NA	neutral	0.35	neutral	3.75	neutral	-0.74	neutral	4.29	neutral_impact	0.2	0.8	neutral	0.97	neutral	-0.84	0.04	neutral	0.5	0.6	NA	NA	0.02	neutral	0.07	neutral	0.13	neutral	7	0.65	neutral	0.68	deleterious	-4	neutral	0.10	neutral	2.1	high_impact	0.08	medium_impact	-1.02	low_impact	0.56	0.8	28.03	39.33	0.5	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12341	12341	C	T	MI.19236	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	5	2	T	I	aCc/aTc	-0.2	0	0	unknown	NA	neutral	0.4	neutral	3.76	neutral	-1.04	neutral	-2.12	neutral_impact	-0.2	0.86	neutral	0.87	neutral	0.80	9.48	deleterious	0.32	0.5	NA	NA	0.12	neutral	0.28	neutral	0.14	neutral	7	0.6	neutral	0.7	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.14	medium_impact	-1.39	low_impact	0.30	0.8	28.03	39.33	0.37	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12343	12343	A	T	MI.19237	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	7	3	M	L	Atg/Ttg	-5.5	0	0	unknown	NA	neutral	1	neutral	3.93	neutral	1.03	neutral	0.17	low_impact	0.88	0.86	neutral	0.93	neutral	-0.25	0.85	neutral	0.35	0.5	NA	NA	0.05	neutral	0.23	neutral	0.12	neutral	8	0	neutral	1	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	1.89	high_impact	-0.4	medium_impact	0.43	0.8	17.91	17.43	0.34	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12343	12343	A	G	MI.19238	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	7	3	M	V	Atg/Gtg	-5.5	0	0	unknown	NA	neutral	0.49	neutral	3.83	neutral	0.92	neutral	-1.1	low_impact	1.73	0.77	neutral	0.57	neutral	-0.03	2.34	deleterious	0.38	0.5	NA	NA	0.15	neutral	0.36	neutral	0.18	neutral	6	0.51	neutral	0.75	deleterious	-4	neutral	0.23	neutral	2.1	high_impact	0.22	medium_impact	0.38	medium_impact	0.37	0.8	17.91	17.43	0.31	N	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12343	12343	A	C	MI.19239	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	7	3	M	L	Atg/Ctg	-5.5	0	0	unknown	NA	neutral	1	neutral	3.93	neutral	1.03	neutral	0.17	low_impact	0.88	0.86	neutral	0.93	neutral	-0.34	0.53	neutral	0.35	0.5	NA	NA	0.05	neutral	0.23	neutral	0.12	neutral	8	0	neutral	1	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	1.89	high_impact	-0.4	medium_impact	0.43	0.8	17.91	17.43	0.34	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5925	5925	T	G	MI.1924	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	22	8	F	V	Ttc/Gtc	-2.42	0	0	possibly_damaging	0.49	deleterious	0.01	neutral	-1.04	neutral	-0.88	neutral	-0.75	medium_impact	2.53	0.63	neutral	0.48	neutral	3.87	23.50	deleterious	0.26	0.55	0.26	neutral	0.79	disease	0.62	disease	0.71	disease	4	0.99	deleterious	0.26	neutral	4	deleterious	0.45	deleterious	-0.74	medium_impact	-0.92	medium_impact	1.24	medium_impact	0.41	0.9	5.85	21.28	0.37	N	0.84	polymorphism	0.97	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12344	12344	T	C	MI.19240	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	8	3	M	T	aTg/aCg	-8.95	0	0	unknown	NA	neutral	0.49	neutral	3.74	neutral	0.02	neutral	-2.39	medium_impact	2.07	0.59	damaging	0.4	neutral	0.11	3.66	deleterious	0.42	0.55	NA	NA	0.22	neutral	0.38	neutral	0.21	neutral	6	0.51	neutral	0.75	deleterious	-1	neutral	0.27	neutral	2.1	high_impact	0.22	medium_impact	0.69	medium_impact	0.28	0.8	17.91	17.43	0.34	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	COSM488731	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12344	12344	T	A	MI.19241	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	8	3	M	K	aTg/aAg	-8.95	0	0	unknown	NA	neutral	0.35	neutral	3.74	neutral	0.19	deleterious	-3.34	medium_impact	2.07	0.62	neutral	0.4	neutral	2.29	18.13	deleterious	0.26	0.45	NA	NA	0.32	neutral	0.63	disease	0.29	neutral	4	0.65	neutral	0.68	deleterious	-1	neutral	0.34	neutral	2.1	high_impact	0.08	medium_impact	0.69	medium_impact	0.46	0.8	17.91	17.43	0.34	N	0.91	polymorphism	1	0.10	.	.	.	.	.	breast tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12345	12345	G	C	MI.19242	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	9	3	M	I	atG/atC	-0.66	0	0	unknown	NA	neutral	0.58	neutral	3.82	neutral	0.73	neutral	-0.74	medium_impact	2.07	0.76	neutral	0.83	neutral	0.72	8.94	deleterious	0.36	0.5	NA	NA	0.16	neutral	0.33	neutral	0.19	neutral	6	0.42	neutral	0.79	deleterious	-1	neutral	0.23	neutral	2.1	high_impact	0.31	medium_impact	0.69	medium_impact	0.49	0.8	17.91	17.43	0.33	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12345	12345	G	T	MI.19243	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	9	3	M	I	atG/atT	-0.66	0	0	unknown	NA	neutral	0.58	neutral	3.82	neutral	0.73	neutral	-0.74	medium_impact	2.07	0.76	neutral	0.83	neutral	0.83	9.63	deleterious	0.36	0.5	NA	NA	0.16	neutral	0.33	neutral	0.19	neutral	6	0.42	neutral	0.79	deleterious	-1	neutral	0.23	neutral	2.1	high_impact	0.31	medium_impact	0.69	medium_impact	0.49	0.8	17.91	17.43	0.34	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12346	12346	C	A	MI.19244	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	10	4	H	N	Cac/Aac	0.03	0	0	unknown	NA	neutral	0.4	neutral	3.83	neutral	0.23	neutral	-0.3	low_impact	0.8	0.82	neutral	0.89	neutral	0.71	8.87	deleterious	0.65	0.7	NA	NA	0.1	neutral	0.46	neutral	0.13	neutral	7	0.6	neutral	0.7	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.14	medium_impact	-0.47	medium_impact	0.55	0.8	27.03	26.34	0.41	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12346	12346	C	T	MI.19245	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	10	4	H	Y	Cac/Tac	0.03	0	0	unknown	NA	neutral	1	neutral	3.81	neutral	0.8	neutral	1.4	neutral_impact	-0.94	0.94	neutral	0.86	neutral	0.25	5.21	deleterious	0.52	0.6	NA	NA	0.11	neutral	0.25	neutral	0.13	neutral	7	0	neutral	1	deleterious	-4	neutral	0.18	neutral	2.1	high_impact	1.89	high_impact	-2.06	low_impact	0.39	0.8	27.03	26.34	0.21	N	0.03	polymorphism	1	0.00	rs200279497	Likely_benign	not_provided	438635	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12346	12346	C	G	MI.19246	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	10	4	H	D	Cac/Gac	0.03	0	0	unknown	NA	neutral	0.2	neutral	3.81	neutral	0.04	neutral	-1.49	low_impact	0.8	0.76	neutral	0.76	neutral	1.01	10.70	neutral	0.32	0.5	NA	NA	0.21	neutral	0.55	disease	0.25	neutral	5	0.8	neutral	0.6	deleterious	-4	neutral	0.17	neutral	2.1	high_impact	-0.1	medium_impact	-0.47	medium_impact	0.58	0.8	27.03	26.34	0.38	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12347	12347	A	T	MI.19247	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	11	4	H	L	cAc/cTc	-3.65	0	0	unknown	NA	neutral	0.88	neutral	3.87	neutral	1.25	neutral	1	neutral_impact	-0.44	0.9	neutral	0.92	neutral	0.44	6.96	deleterious	0.28	0.45	NA	NA	0.17	neutral	0.27	neutral	0.15	neutral	7	0.12	neutral	0.94	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	0.71	medium_impact	-1.61	low_impact	0.42	0.8	27.03	26.34	0.31	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12347	12347	A	G	MI.19248	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	11	4	H	R	cAc/cGc	-3.65	0	0	unknown	NA	neutral	0.34	neutral	3.83	neutral	0.57	neutral	-1.18	low_impact	0.8	0.78	neutral	0.78	neutral	0.09	3.49	deleterious	0.52	0.6	NA	NA	0.21	neutral	0.46	neutral	0.22	neutral	6	0.66	neutral	0.67	deleterious	-4	neutral	0.22	neutral	2.1	high_impact	0.07	medium_impact	-0.47	medium_impact	0.28	0.8	27.03	26.34	0.34	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12347	12347	A	C	MI.19249	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	11	4	H	P	cAc/cCc	-3.65	0	0	unknown	NA	neutral	0.28	neutral	3.78	neutral	-0.83	neutral	-1.86	neutral_impact	0.11	0.7	neutral	0.71	neutral	0.43	6.87	deleterious	0.31	0.45	NA	NA	0.35	neutral	0.63	disease	0.29	neutral	4	0.72	neutral	0.64	deleterious	-4	neutral	0.29	neutral	2.1	high_impact	0.01	medium_impact	-1.1	low_impact	0.41	0.8	27.03	26.34	0.37	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5926	5926	T	G	MI.1925	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	23	8	F	C	tTc/tGc	7.53	1	0	probably_damaging	0.96	neutral	0.06	neutral	-1.06	deleterious	-3.5	neutral	-0.84	medium_impact	2.88	0.64	neutral	0.49	neutral	3.88	23.50	deleterious	0.21	0.55	0.63	disease	0.81	disease	0.38	neutral	0.61	disease	2	0.99	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-2.06	low_impact	-0.47	medium_impact	1.56	medium_impact	0.22	0.9	5.85	21.28	0.54	P	0.91	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12348	12348	C	A	MI.19250	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	12	4	H	Q	caC/caA	0.03	0	0	unknown	NA	neutral	0.28	neutral	3.83	neutral	0.57	neutral	-1.03	low_impact	0.8	0.78	neutral	0.82	neutral	0.95	10.39	neutral	0.6	0.65	NA	NA	0.12	neutral	0.46	neutral	0.17	neutral	7	0.72	neutral	0.64	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	0.01	medium_impact	-0.47	medium_impact	0.55	0.8	27.03	26.34	0.41	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12348	12348	C	G	MI.19251	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	12	4	H	Q	caC/caG	0.03	0	0	unknown	NA	neutral	0.28	neutral	3.83	neutral	0.57	neutral	-1.03	low_impact	0.8	0.78	neutral	0.82	neutral	0.61	8.23	deleterious	0.6	0.65	NA	NA	0.12	neutral	0.46	neutral	0.17	neutral	7	0.72	neutral	0.64	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	0.01	medium_impact	-0.47	medium_impact	0.55	0.8	27.03	26.34	0.42	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12349	12349	A	C	MI.19252	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	13	5	T	P	Act/Cct	-5.78	0	0	unknown	NA	neutral	0.31	neutral	3.69	neutral	-1.53	neutral	-1.39	medium_impact	2.02	0.82	neutral	0.83	neutral	0.55	7.77	deleterious	0.29	0.45	NA	NA	0.21	neutral	0.4	neutral	0.19	neutral	6	0.69	neutral	0.66	deleterious	-1	neutral	0.22	neutral	2.1	high_impact	0.04	medium_impact	0.64	medium_impact	0.68	0.85	27.03	13.76	0.4	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12349	12349	A	T	MI.19253	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	13	5	T	S	Act/Tct	-5.78	0	0	unknown	NA	neutral	0.55	neutral	3.8	neutral	-0.08	neutral	-0.1	neutral_impact	0.68	0.88	neutral	0.97	neutral	-0.90	0.03	neutral	0.5	0.6	NA	NA	0.03	neutral	0.2	neutral	0.13	neutral	7	0.45	neutral	0.78	deleterious	-4	neutral	0.09	neutral	2.1	high_impact	0.28	medium_impact	-0.58	medium_impact	0.53	0.8	27.03	13.76	0.45	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	COSM1155519	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12349	12349	A	G	MI.19254	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	13	5	T	A	Act/Gct	-5.78	0	0	unknown	NA	neutral	0.48	neutral	3.79	neutral	0.08	neutral	-0.92	low_impact	1.48	0.89	neutral	0.91	neutral	0.30	5.68	deleterious	0.52	0.6	NA	NA	0.07	neutral	0.45	neutral	0.12	neutral	8	0.52	neutral	0.74	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	0.21	medium_impact	0.15	medium_impact	0.43	0.8	27.03	13.76	0.47	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12350	12350	C	G	MI.19255	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	14	5	T	S	aCt/aGt	-5.55	0	0	unknown	NA	neutral	0.55	neutral	3.8	neutral	-0.08	neutral	-0.1	neutral_impact	0.68	0.88	neutral	0.97	neutral	-0.53	0.19	neutral	0.5	0.6	NA	NA	0.03	neutral	0.2	neutral	0.13	neutral	7	0.45	neutral	0.78	deleterious	-4	neutral	0.09	neutral	2.1	high_impact	0.28	medium_impact	-0.58	medium_impact	0.53	0.8	27.03	13.76	0.43	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12350	12350	C	A	MI.19256	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	14	5	T	N	aCt/aAt	-5.55	0	0	unknown	NA	neutral	0.26	neutral	3.74	neutral	-0.75	neutral	-0.56	low_impact	1.08	0.88	neutral	0.89	neutral	0.49	7.37	deleterious	0.53	0.6	NA	NA	0.12	neutral	0.25	neutral	0.15	neutral	7	0.74	neutral	0.63	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	-0.02	medium_impact	-0.22	medium_impact	0.54	0.8	27.03	13.76	0.48	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12350	12350	C	T	MI.19257	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	14	5	T	I	aCt/aTt	-5.55	0	0	unknown	NA	neutral	0.67	neutral	3.73	neutral	-0.49	neutral	-1.44	medium_impact	2.37	0.86	neutral	0.87	neutral	1.04	10.90	neutral	0.39	0.5	NA	NA	0.17	neutral	0.32	neutral	0.17	neutral	7	0.33	neutral	0.84	deleterious	-1	neutral	0.21	neutral	2.1	high_impact	0.4	medium_impact	0.96	medium_impact	0.60	0.8	27.03	13.76	0.28	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12352	12352	A	T	MI.19258	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	16	6	T	S	Act/Tct	-10.83	0	0	unknown	NA	neutral	0.49	neutral	3.79	neutral	-0.17	neutral	0.12	neutral_impact	0.32	0.9	neutral	0.97	neutral	-1.10	0.01	neutral	0.51	0.6	NA	NA	0.02	neutral	0.3	neutral	0.13	neutral	7	0.51	neutral	0.75	deleterious	-4	neutral	0.08	neutral	2.1	high_impact	0.22	medium_impact	-0.91	medium_impact	0.46	0.8	5.31	9.93	0.51	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12352	12352	A	G	MI.19259	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	16	6	T	A	Act/Gct	-10.83	0	0	unknown	NA	neutral	0.31	neutral	3.77	neutral	-0.02	neutral	-1.28	low_impact	1.59	0.85	neutral	0.88	neutral	1.79	14.92	neutral	0.54	0.6	NA	NA	0.11	neutral	0.7	disease	0.25	neutral	5	0.69	neutral	0.66	deleterious	-4	neutral	0.14	neutral	2.1	high_impact	0.04	medium_impact	0.25	medium_impact	0.34	0.8	5.31	9.93	0.43	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5926	5926	T	A	MI.1926	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	23	8	F	Y	tTc/tAc	7.53	1	0	benign	0.01	neutral	0.11	neutral	-0.99	neutral	-2.18	neutral	-0.18	low_impact	1.64	0.65	neutral	0.8	neutral	2.86	21.70	deleterious	0.31	0.55	0.25	neutral	0.39	neutral	0.31	neutral	0.44	neutral	1	0.89	neutral	0.55	deleterious	-6	neutral	0.17	neutral	1.12	medium_impact	-0.31	medium_impact	0.42	medium_impact	0.54	0.9	5.85	21.28	0.68	P	0.58	disease_causing	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12352	12352	A	C	MI.19260	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	16	6	T	P	Act/Cct	-10.83	0	0	unknown	NA	neutral	0.18	neutral	3.68	neutral	-2.06	neutral	-2.24	low_impact	1	0.81	neutral	0.79	neutral	0.68	8.72	deleterious	0.3	0.45	NA	NA	0.42	neutral	0.8	disease	0.51	disease	0	0.82	neutral	0.59	deleterious	-4	neutral	0.27	neutral	2.1	high_impact	-0.13	medium_impact	-0.29	medium_impact	0.51	0.8	5.31	9.93	0.39	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12353	12353	C	A	MI.19261	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	17	6	T	N	aCt/aAt	-0.5	0	0	unknown	NA	neutral	0.24	neutral	3.71	neutral	-1.09	neutral	-1.55	medium_impact	2.29	0.78	neutral	0.74	neutral	1.87	15.41	deleterious	0.55	0.6	NA	NA	0.28	neutral	0.73	disease	0.34	neutral	3	0.76	neutral	0.62	deleterious	-1	neutral	0.18	neutral	2.1	high_impact	-0.04	medium_impact	0.89	medium_impact	0.57	0.8	5.31	9.93	0.36	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12353	12353	C	T	MI.19262	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	17	6	T	I	aCt/aTt	-0.5	0	0	unknown	NA	neutral	0.49	neutral	3.74	neutral	-0.18	neutral	-2.19	medium_impact	2.29	0.75	neutral	0.76	neutral	2.20	17.49	deleterious	0.33	0.5	NA	NA	0.26	neutral	0.69	disease	0.29	neutral	4	0.51	neutral	0.75	deleterious	-1	neutral	0.19	neutral	2.1	high_impact	0.22	medium_impact	0.89	medium_impact	0.50	0.8	5.31	9.93	0.37	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12353	12353	C	G	MI.19263	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	17	6	T	S	aCt/aGt	-0.5	0	0	unknown	NA	neutral	0.49	neutral	3.79	neutral	-0.17	neutral	0.12	neutral_impact	0.32	0.9	neutral	0.97	neutral	-0.92	0.02	neutral	0.51	0.6	NA	NA	0.02	neutral	0.3	neutral	0.13	neutral	7	0.51	neutral	0.75	deleterious	-4	neutral	0.08	neutral	2.1	high_impact	0.22	medium_impact	-0.91	medium_impact	0.46	0.8	5.31	9.93	0.48	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12355	12355	A	G	MI.19264	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	19	7	M	V	Ata/Gta	-10.6	0	0	unknown	NA	neutral	0.38	neutral	3.86	neutral	1.04	neutral	-0.88	low_impact	1.83	0.81	neutral	0.88	neutral	-1.47	0.00	neutral	0.48	0.55	NA	NA	0.16	neutral	0.58	disease	0.21	neutral	6	0.62	neutral	0.69	deleterious	-4	neutral	0.17	neutral	2.1	high_impact	0.12	medium_impact	0.47	medium_impact	0.28	0.8	25.04	21.26	0.33	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12355	12355	A	C	MI.19265	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	19	7	M	L	Ata/Cta	-10.6	0	0	unknown	NA	neutral	1	neutral	3.9	neutral	1.6	neutral	-0.07	neutral_impact	0.36	0.9	neutral	0.99	neutral	-0.41	0.37	neutral	0.43	0.55	NA	NA	0.07	neutral	0.33	neutral	0.12	neutral	8	0	neutral	1	deleterious	-4	neutral	0.12	neutral	2.1	high_impact	1.89	high_impact	-0.87	medium_impact	0.45	0.8	25.04	21.26	0.44	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12355	12355	A	T	MI.19266	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	19	7	M	L	Ata/Tta	-10.6	0	0	unknown	NA	neutral	1	neutral	3.9	neutral	1.6	neutral	-0.07	neutral_impact	0.36	0.9	neutral	0.99	neutral	-0.22	0.99	neutral	0.43	0.55	NA	NA	0.07	neutral	0.33	neutral	0.12	neutral	8	0	neutral	1	deleterious	-4	neutral	0.12	neutral	2.1	high_impact	1.89	high_impact	-0.87	medium_impact	0.45	0.8	25.04	21.26	0.44	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12356	12356	T	A	MI.19267	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	20	7	M	K	aTa/aAa	-6.47	0	0	unknown	NA	neutral	0.16	neutral	3.81	neutral	0.37	neutral	-1.93	low_impact	1.83	0.78	neutral	0.81	neutral	1.12	11.34	neutral	0.25	0.45	NA	NA	0.33	neutral	0.7	disease	0.32	neutral	4	0.84	neutral	0.58	deleterious	-4	neutral	0.26	neutral	2.1	high_impact	-0.17	medium_impact	0.47	medium_impact	0.42	0.8	25.04	21.26	0.39	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12356	12356	T	C	MI.19268	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	20	7	M	T	aTa/aCa	-6.47	0	0	unknown	NA	neutral	0.56	neutral	3.83	neutral	0.5	neutral	-0.76	neutral_impact	0.8	0.89	neutral	0.93	neutral	-0.28	0.72	neutral	0.46	0.55	NA	NA	0.15	neutral	0.4	neutral	0.16	neutral	7	0.44	neutral	0.78	deleterious	-4	neutral	0.17	neutral	2.1	high_impact	0.29	medium_impact	-0.47	medium_impact	0.15	0.8	25.04	21.26	0.35	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12357	12357	A	T	MI.19269	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	21	7	M	I	atA/atT	-2.8	0	0	unknown	NA	neutral	0.61	neutral	3.84	neutral	0.75	neutral	-0.48	neutral_impact	0.28	0.91	neutral	0.97	neutral	-0.29	0.72	neutral	0.44	0.55	NA	NA	0.11	neutral	0.36	neutral	0.13	neutral	8	0.39	neutral	0.81	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.34	medium_impact	-0.95	medium_impact	0.37	0.8	25.04	21.26	0.36	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5926	5926	T	C	MI.1927	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	23	8	F	S	tTc/tCc	7.53	1	0	probably_damaging	0.96	deleterious	0.04	neutral	-1.06	neutral	-1.94	neutral	-0.9	medium_impact	2	0.64	neutral	0.47	neutral	4.08	23.70	deleterious	0.23	0.55	0.32	neutral	0.77	disease	0.59	disease	0.66	disease	3	0.99	deleterious	0.04	neutral	5	deleterious	0.75	deleterious	-2.06	low_impact	-0.58	medium_impact	0.75	medium_impact	0.36	0.9	5.85	21.28	0.52	P	0.85	disease_causing	1	0.03	.	.	.	.	.	.	COSM1331634	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12357	12357	A	C	MI.19270	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	21	7	M	I	atA/atC	-2.8	0	0	unknown	NA	neutral	0.61	neutral	3.84	neutral	0.75	neutral	-0.48	neutral_impact	0.28	0.91	neutral	0.97	neutral	-0.33	0.57	neutral	0.44	0.55	NA	NA	0.11	neutral	0.36	neutral	0.13	neutral	8	0.39	neutral	0.81	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.34	medium_impact	-0.95	medium_impact	0.37	0.8	25.04	21.26	0.37	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12358	12358	A	C	MI.19271	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	22	8	T	P	Acc/Ccc	-9.22	0	0.16	unknown	NA	neutral	0.17	neutral	3.71	neutral	-1.88	neutral	-1.97	low_impact	1.94	0.72	neutral	0.86	neutral	0.47	7.16	deleterious	0.27	0.45	NA	NA	0.34	neutral	0.55	disease	0.27	neutral	5	0.83	neutral	0.59	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	-0.15	medium_impact	0.57	medium_impact	0.52	0.8	19.9	15.82	0.42	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12358	12358	A	T	MI.19272	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	22	8	T	S	Acc/Tcc	-9.22	0	0.16	unknown	NA	neutral	0.69	neutral	3.78	neutral	-0.15	neutral	-0.89	low_impact	1.38	0.9	neutral	0.97	neutral	0.01	2.71	deleterious	0.57	0.65	NA	NA	0.08	neutral	0.17	neutral	0.11	neutral	8	0.31	neutral	0.85	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	0.42	medium_impact	0.06	medium_impact	0.51	0.8	19.9	15.82	0.48	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12358	12358	A	G	MI.19273	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	22	8	T	A	Acc/Gcc	-9.22	0	0.16	unknown	NA	neutral	0.47	neutral	3.79	neutral	-0.19	neutral	-1.34	low_impact	1.04	0.88	neutral	0.92	neutral	0.34	6.06	deleterious	0.52	0.6	NA	NA	0.08	neutral	0.43	neutral	0.13	neutral	7	0.53	neutral	0.74	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	0.2	medium_impact	-0.25	medium_impact	0.39	0.8	19.9	15.82	0.33	N	0.17	polymorphism	1	0.02	rs201027657	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12359	12359	C	G	MI.19274	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	23	8	T	S	aCc/aGc	-1.19	0	0	unknown	NA	neutral	0.69	neutral	3.78	neutral	-0.15	neutral	-0.89	low_impact	1.38	0.9	neutral	0.97	neutral	0.19	4.61	deleterious	0.57	0.65	NA	NA	0.08	neutral	0.17	neutral	0.11	neutral	8	0.31	neutral	0.85	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	0.42	medium_impact	0.06	medium_impact	0.51	0.8	19.9	15.82	0.43	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12359	12359	C	A	MI.19275	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	23	8	T	N	aCc/aAc	-1.19	0	0	unknown	NA	neutral	0.58	neutral	3.73	neutral	-1.14	neutral	-1.52	low_impact	1.94	0.72	neutral	0.72	neutral	0.78	9.34	deleterious	0.6	0.65	NA	NA	0.18	neutral	0.41	neutral	0.21	neutral	6	0.42	neutral	0.79	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.31	medium_impact	0.57	medium_impact	0.46	0.8	19.9	15.82	0.34	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12359	12359	C	T	MI.19276	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	23	8	T	I	aCc/aTc	-1.19	0	0	unknown	NA	neutral	1	neutral	3.78	neutral	-0.37	neutral	-0.32	neutral_impact	0.55	0.89	neutral	0.97	neutral	-0.38	0.42	neutral	0.36	0.5	NA	NA	0.1	neutral	0.24	neutral	0.12	neutral	8	0	neutral	1	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	1.89	high_impact	-0.7	medium_impact	0.50	0.8	19.9	15.82	0.34	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12361	12361	A	C	MI.19277	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	25	9	T	P	Acc/Ccc	-3.71	0	0.06	unknown	NA	neutral	0.21	neutral	3.7	neutral	-2.49	neutral	-2	low_impact	1.2	0.82	neutral	0.69	neutral	2.07	16.66	deleterious	0.22	0.45	NA	NA	0.38	neutral	0.52	disease	0.29	neutral	4	0.79	neutral	0.61	deleterious	-4	neutral	0.27	neutral	2.1	high_impact	-0.09	medium_impact	-0.11	medium_impact	0.51	0.8	20.9	14.56	0.37	N	0.39	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12361	12361	A	T	MI.19278	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	25	9	T	S	Acc/Tcc	-3.71	0	0.06	unknown	NA	neutral	0.42	neutral	3.77	neutral	-0.75	neutral	-0.86	low_impact	0.85	0.91	neutral	0.94	neutral	1.89	15.50	deleterious	0.54	0.6	NA	NA	0.09	neutral	0.19	neutral	0.12	neutral	8	0.58	neutral	0.71	deleterious	-4	neutral	0.14	neutral	2.1	high_impact	0.16	medium_impact	-0.43	medium_impact	0.53	0.8	20.9	14.56	0.52	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12361	12361	A	G	MI.19279	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	25	9	T	A	Acc/Gcc	-3.71	0	0.06	unknown	NA	neutral	0.51	neutral	3.79	neutral	-0.37	neutral	-0.39	neutral_impact	0.65	0.88	neutral	0.91	neutral	2.06	16.59	deleterious	0.45	0.55	NA	NA	0.08	neutral	0.4	neutral	0.12	neutral	8	0.49	neutral	0.76	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	0.24	medium_impact	-0.61	medium_impact	0.47	0.8	20.9	14.56	0.41	N	0.05	polymorphism	1	0.01	rs3134561	.	.	.	.	.	.	.	.	A12361G	Non-alcoholic fatty liver disease	+	-	Reported	1	N	P	N,P	neutral
chrM	5927	5927	C	G	MI.1928	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	24	8	F	L	ttC/ttG	2.44	0.99	0	benign	0.21	deleterious	0.03	neutral	-1.01	neutral	-0.57	neutral	-0.61	medium_impact	2.06	0.64	neutral	0.51	neutral	4.15	23.80	deleterious	0.29	0.55	0.24	neutral	0.64	disease	0.38	neutral	0.48	neutral	0	0.97	neutral	0.41	neutral	1	deleterious	0.29	neutral	-0.22	medium_impact	-0.65	medium_impact	0.8	medium_impact	0.48	0.9	5.85	21.28	0.5	P	0.81	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12362	12362	C	G	MI.19280	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	26	9	T	S	aCc/aGc	-9.45	0	0	unknown	NA	neutral	0.42	neutral	3.77	neutral	-0.75	neutral	-0.86	low_impact	0.85	0.91	neutral	0.94	neutral	1.62	13.96	neutral	0.54	0.6	NA	NA	0.09	neutral	0.19	neutral	0.12	neutral	8	0.58	neutral	0.71	deleterious	-4	neutral	0.14	neutral	2.1	high_impact	0.16	medium_impact	-0.43	medium_impact	0.53	0.8	20.9	14.56	0.51	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12362	12362	C	T	MI.19281	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	26	9	T	I	aCc/aTc	-9.45	0	0	unknown	NA	neutral	0.4	neutral	3.79	neutral	-0.58	neutral	1.95	neutral_impact	-0.85	0.93	neutral	0.98	neutral	0.37	6.39	deleterious	0.32	0.5	NA	NA	0.11	neutral	0.18	neutral	0.13	neutral	7	0.6	neutral	0.7	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.14	medium_impact	-1.98	low_impact	0.51	0.8	20.9	14.56	0.43	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12362	12362	C	A	MI.19282	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	26	9	T	N	aCc/aAc	-9.45	0	0	unknown	NA	neutral	0.31	neutral	3.72	neutral	-1.42	neutral	-2.01	low_impact	1.2	0.76	neutral	0.7	neutral	1.78	14.89	neutral	0.5	0.6	NA	NA	0.19	neutral	0.37	neutral	0.21	neutral	6	0.69	neutral	0.66	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.04	medium_impact	-0.11	medium_impact	0.52	0.8	20.9	14.56	0.38	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12364	12364	C	A	MI.19283	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	28	10	L	M	Cta/Ata	-4.63	0	0	unknown	NA	neutral	0.22	neutral	3.54	neutral	-2.24	neutral	0.38	low_impact	1	0.85	neutral	0.96	neutral	0.19	4.52	deleterious	0.27	0.45	NA	NA	0.08	neutral	0.21	neutral	0.18	neutral	6	0.78	neutral	0.61	deleterious	-4	neutral	0.20	neutral	2.1	high_impact	-0.07	medium_impact	-0.29	medium_impact	0.59	0.8	7.96	10.12	0.49	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12364	12364	C	G	MI.19284	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	28	10	L	V	Cta/Gta	-4.63	0	0	unknown	NA	neutral	0.5	neutral	3.69	neutral	-0.55	neutral	-0.69	low_impact	1.27	0.85	neutral	0.97	neutral	0.41	6.73	deleterious	0.3	0.45	NA	NA	0.17	neutral	0.26	neutral	0.2	neutral	6	0.5	neutral	0.75	deleterious	-4	neutral	0.21	neutral	2.1	high_impact	0.23	medium_impact	-0.04	medium_impact	0.38	0.8	7.96	10.12	0.38	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12365	12365	T	G	MI.19285	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	29	10	L	R	cTa/cGa	-11.74	0	0	unknown	NA	neutral	0.35	neutral	3.5	deleterious	-3.07	deleterious	-3.46	medium_impact	2.42	0.57	damaging	0.57	neutral	2.29	18.13	deleterious	0.22	0.45	NA	NA	0.66	disease	0.67	disease	0.7	disease	4	0.65	neutral	0.68	deleterious	-1	neutral	0.45	deleterious	2.1	high_impact	0.08	medium_impact	1.01	medium_impact	0.43	0.8	7.96	10.12	0.34	N	0.76	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12365	12365	T	A	MI.19286	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	29	10	L	Q	cTa/cAa	-11.74	0	0	unknown	NA	neutral	0.29	neutral	3.49	deleterious	-3.12	deleterious	-3.01	medium_impact	2.42	0.63	neutral	0.65	neutral	2.21	17.59	deleterious	0.22	0.45	NA	NA	0.48	neutral	0.54	disease	0.44	neutral	1	0.71	neutral	0.65	deleterious	-1	neutral	0.28	neutral	2.1	high_impact	0.02	medium_impact	1.01	medium_impact	0.47	0.8	7.96	10.12	0.38	N	0.66	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12365	12365	T	C	MI.19287	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	29	10	L	P	cTa/cCa	-11.74	0	0	unknown	NA	neutral	0.2	neutral	3.48	deleterious	-3.92	deleterious	-3.91	medium_impact	2.42	0.53	damaging	0.58	neutral	2.03	16.38	deleterious	0.23	0.45	NA	NA	0.55	disease	0.74	disease	0.73	disease	5	0.8	neutral	0.6	deleterious	-1	neutral	0.45	deleterious	2.1	high_impact	-0.1	medium_impact	1.01	medium_impact	0.39	0.8	7.96	10.12	0.41	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12367	12367	A	G	MI.19288	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	31	11	T	A	Acc/Gcc	-11.51	0	0	unknown	NA	neutral	0.32	neutral	3.78	deleterious	-3.48	neutral	-2.31	low_impact	1.23	0.91	neutral	0.99	neutral	0.19	4.57	deleterious	0.56	0.6	NA	NA	0.11	neutral	0.23	neutral	0.18	neutral	6	0.68	neutral	0.66	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	0.05	medium_impact	-0.08	medium_impact	0.40	0.8	18.57	13.16	0.45	N	0.03	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12367	12367	A	C	MI.19289	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	31	11	T	P	Acc/Ccc	-11.51	0	0	unknown	NA	neutral	0.11	neutral	3.67	deleterious	-6.34	deleterious	-3.89	medium_impact	2.58	0.63	neutral	0.52	neutral	1.54	13.53	neutral	0.27	0.45	NA	NA	0.55	disease	0.53	disease	0.6	disease	2	0.89	neutral	0.56	deleterious	-1	neutral	0.35	neutral	2.1	high_impact	-0.27	medium_impact	1.15	medium_impact	0.50	0.8	18.57	13.16	0.39	N	0.67	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5927	5927	C	A	MI.1929	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	24	8	F	L	ttC/ttA	2.44	0.99	0	benign	0.21	deleterious	0.03	neutral	-1.01	neutral	-0.57	neutral	-0.61	medium_impact	2.06	0.64	neutral	0.51	neutral	4.39	24.10	deleterious	0.29	0.55	0.24	neutral	0.64	disease	0.38	neutral	0.48	neutral	0	0.97	neutral	0.41	neutral	1	deleterious	0.29	neutral	-0.22	medium_impact	-0.65	medium_impact	0.8	medium_impact	0.48	0.9	5.85	21.28	0.51	P	0.81	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12367	12367	A	T	MI.19290	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	31	11	T	S	Acc/Tcc	-11.51	0	0	unknown	NA	neutral	0.79	neutral	3.74	deleterious	-4.44	neutral	-1.66	low_impact	1.14	0.89	neutral	0.98	neutral	-0.31	0.62	neutral	0.63	0.65	NA	NA	0.09	neutral	0.18	neutral	0.19	neutral	6	0.21	neutral	0.9	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.55	medium_impact	-0.16	medium_impact	0.51	0.8	18.57	13.16	0.41	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12368	12368	C	T	MI.19291	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	32	11	T	I	aCc/aTc	-0.5	0	0	unknown	NA	neutral	0.58	neutral	3.8	deleterious	-5.23	deleterious	-2.52	low_impact	1.34	0.89	neutral	0.96	neutral	-0.08	1.92	neutral	0.41	0.5	NA	NA	0.22	neutral	0.22	neutral	0.19	neutral	6	0.42	neutral	0.79	deleterious	-4	neutral	0.19	neutral	2.1	high_impact	0.31	medium_impact	0.02	medium_impact	0.52	0.8	18.57	13.16	0.33	N	0.22	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12368	12368	C	A	MI.19292	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	32	11	T	N	aCc/aAc	-0.5	0	0	unknown	NA	neutral	0.15	neutral	3.69	deleterious	-5.88	deleterious	-3.13	medium_impact	2.58	0.74	neutral	0.64	neutral	1.86	15.35	deleterious	0.56	0.6	NA	NA	0.34	neutral	0.24	neutral	0.21	neutral	6	0.85	neutral	0.58	deleterious	-1	neutral	0.21	neutral	2.1	high_impact	-0.18	medium_impact	1.15	medium_impact	0.53	0.8	18.57	13.16	0.43	N	0.45	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12368	12368	C	G	MI.19293	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	32	11	T	S	aCc/aGc	-0.5	0	0	unknown	NA	neutral	0.79	neutral	3.74	deleterious	-4.44	neutral	-1.66	low_impact	1.14	0.89	neutral	0.98	neutral	-0.11	1.66	neutral	0.63	0.65	NA	NA	0.09	neutral	0.18	neutral	0.19	neutral	6	0.21	neutral	0.9	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	0.55	medium_impact	-0.16	medium_impact	0.51	0.8	18.57	13.16	0.37	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12370	12370	C	A	MI.19294	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	34	12	L	M	Ctg/Atg	-5.55	0	0	unknown	NA	neutral	0.23	neutral	3.41	deleterious	-5.57	neutral	-1.25	low_impact	1.38	0.82	neutral	0.9	neutral	0.79	9.40	deleterious	0.31	0.45	NA	NA	0.12	neutral	0.2	neutral	0.21	neutral	6	0.77	neutral	0.62	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	-0.06	medium_impact	0.06	medium_impact	0.66	0.8	20.56	12.96	0.46	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12370	12370	C	G	MI.19295	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	34	12	L	V	Ctg/Gtg	-5.55	0	0	unknown	NA	neutral	0.17	neutral	3.49	deleterious	-5.41	neutral	-2.27	medium_impact	2.4	0.81	neutral	0.7	neutral	1.54	13.55	neutral	0.33	0.5	NA	NA	0.18	neutral	0.2	neutral	0.21	neutral	6	0.83	neutral	0.59	deleterious	-1	neutral	0.24	neutral	2.1	high_impact	-0.15	medium_impact	0.99	medium_impact	0.37	0.8	20.56	12.96	0.4	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12371	12371	T	C	MI.19296	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	35	12	L	P	cTg/cCg	-3.71	0	0	unknown	NA	neutral	0.11	neutral	3.35	deleterious	-9.49	deleterious	-5.83	medium_impact	2.74	0.64	neutral	0.13	damaging	2.01	16.30	deleterious	0.23	0.45	NA	NA	0.54	disease	0.71	disease	0.72	disease	4	0.89	neutral	0.56	deleterious	-1	neutral	0.50	deleterious	2.1	high_impact	-0.27	medium_impact	1.3	medium_impact	0.37	0.8	20.56	12.96	0.25	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12371	12371	T	G	MI.19297	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	35	12	L	R	cTg/cGg	-3.71	0	0	unknown	NA	neutral	0.09	neutral	3.36	deleterious	-9.06	deleterious	-4.99	medium_impact	2.74	0.68	neutral	0.13	damaging	2.32	18.29	deleterious	0.23	0.45	NA	NA	0.63	disease	0.7	disease	0.72	disease	4	0.91	neutral	0.55	deleterious	-1	neutral	0.48	deleterious	2.1	high_impact	-0.32	medium_impact	1.3	medium_impact	0.45	0.8	20.56	12.96	0.27	N	0.99	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12371	12371	T	A	MI.19298	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	35	12	L	Q	cTg/cAg	-3.71	0	0	unknown	NA	neutral	0.06	neutral	3.36	deleterious	-8.93	deleterious	-4.92	medium_impact	2.74	0.74	neutral	0.19	damaging	2.33	18.34	deleterious	0.23	0.45	NA	NA	0.47	neutral	0.59	disease	0.46	neutral	1	0.94	neutral	0.53	deleterious	-1	neutral	0.33	neutral	2.1	high_impact	-0.43	medium_impact	1.3	medium_impact	0.49	0.8	20.56	12.96	0.36	N	0.96	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12373	12373	A	T	MI.19299	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	37	13	T	S	Act/Tct	-4.86	0	0	unknown	NA	neutral	0.38	neutral	3.75	neutral	-1.17	neutral	-1.14	low_impact	1.38	0.88	neutral	0.98	neutral	-0.37	0.47	neutral	0.44	0.55	NA	NA	0.11	neutral	0.19	neutral	0.22	neutral	6	0.62	neutral	0.69	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	0.12	medium_impact	0.06	medium_impact	0.40	0.8	20.07	13.72	0.53	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8617	8617	A	T	MI.193	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	91	31	I	F	Atc/Ttc	-2.65	0	0	benign	0.17	neutral	1	neutral	4.36	neutral	-1.22	neutral	1.85	neutral_impact	-0.65	0.85	neutral	0.95	neutral	-0.91	0.03	neutral	0.44	0.65	0.25	neutral	0.21	neutral	0.18	neutral	0.37	neutral	3	0.17	neutral	0.92	deleterious	-6	neutral	0.30	neutral	-0.1	medium_impact	1.98	high_impact	-1.66	low_impact	0.48	0.9	28.32	22.32	0.3	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5928	5928	T	A	MI.1930	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	25	9	S	T	Tct/Act	-3.11	0	0	probably_damaging	0.9	neutral	0.11	neutral	-0.78	neutral	-1.64	neutral	-0.47	low_impact	1.5	0.54	damaging	0.15	damaging	3.54	23.10	deleterious	0.22	0.55	0.16	neutral	0.66	disease	0.62	disease	0.59	disease	2	0.96	neutral	0.11	neutral	-2	neutral	0.66	deleterious	-1.65	low_impact	-0.31	medium_impact	0.29	medium_impact	0.70	0.9	1.17	6.83	0.33	N	0.42	polymorphism	0.58	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12373	12373	A	C	MI.19300	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	37	13	T	P	Act/Cct	-4.86	0	0	unknown	NA	deleterious	0.04	neutral	3.69	deleterious	-3.32	deleterious	-2.73	medium_impact	2.29	0.65	neutral	0.54	neutral	0.27	5.38	deleterious	0.25	0.45	NA	NA	0.48	neutral	0.61	disease	0.51	disease	0	0.96	neutral	0.52	deleterious	3	deleterious	0.32	neutral	2.1	high_impact	-0.53	medium_impact	0.89	medium_impact	0.45	0.8	20.07	13.72	0.37	N	0.75	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12373	12373	A	G	MI.19301	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	37	13	T	A	Act/Gct	-4.86	0	0	unknown	NA	neutral	0.25	neutral	3.8	neutral	-0.98	neutral	-1.13	low_impact	1.25	0.88	neutral	0.94	neutral	-0.33	0.57	neutral	0.49	0.55	NA	NA	0.06	neutral	0.38	neutral	0.17	neutral	7	0.75	neutral	0.63	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	-0.03	medium_impact	-0.06	medium_impact	0.43	0.8	20.07	13.72	0.52	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12374	12374	C	G	MI.19302	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	38	13	T	S	aCt/aGt	-8.53	0	0	unknown	NA	neutral	0.38	neutral	3.75	neutral	-1.17	neutral	-1.14	low_impact	1.38	0.88	neutral	0.98	neutral	-0.13	1.51	neutral	0.44	0.55	NA	NA	0.11	neutral	0.19	neutral	0.22	neutral	6	0.62	neutral	0.69	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	0.12	medium_impact	0.06	medium_impact	0.40	0.8	20.07	13.72	0.52	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12374	12374	C	A	MI.19303	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	38	13	T	N	aCt/aAt	-8.53	0	0	unknown	NA	neutral	0.15	neutral	3.7	neutral	-2.98	neutral	-2.33	medium_impact	2.29	0.77	neutral	0.67	neutral	0.21	4.78	deleterious	0.47	0.55	NA	NA	0.28	neutral	0.48	neutral	0.21	neutral	6	0.85	neutral	0.58	deleterious	-1	neutral	0.19	neutral	2.1	high_impact	-0.18	medium_impact	0.89	medium_impact	0.70	0.85	20.07	13.72	0.39	N	0.59	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12374	12374	C	T	MI.19304	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	38	13	T	I	aCt/aTt	-8.53	0	0	unknown	NA	neutral	0.35	neutral	3.81	neutral	-0.07	neutral	0.53	low_impact	0.86	0.88	neutral	0.95	neutral	-0.02	2.43	deleterious	0.3	0.45	NA	NA	0.12	neutral	0.15	neutral	0.19	neutral	6	0.65	neutral	0.68	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	0.08	medium_impact	-0.42	medium_impact	0.55	0.8	20.07	13.72	0.55	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12376	12376	T	G	MI.19305	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	40	14	S	A	Tcc/Gcc	-7.84	0	0	unknown	NA	neutral	0.11	neutral	3.84	neutral	0.24	neutral	0.1	low_impact	1.23	0.86	neutral	0.85	neutral	0.73	9.04	deleterious	0.34	0.5	NA	NA	0.06	neutral	0.13	neutral	0.18	neutral	6	0.89	neutral	0.56	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	-0.27	medium_impact	-0.08	medium_impact	0.48	0.8	27.36	21.95	0.6	P	0.15	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12376	12376	T	C	MI.19306	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	40	14	S	P	Tcc/Ccc	-7.84	0	0	unknown	NA	neutral	0.11	neutral	3.77	neutral	-2.03	neutral	-1.39	low_impact	1.57	0.77	neutral	0.81	neutral	0.91	10.16	neutral	0.35	0.5	NA	NA	0.35	neutral	0.29	neutral	0.15	neutral	7	0.89	neutral	0.56	deleterious	-4	neutral	0.28	neutral	2.1	high_impact	-0.27	medium_impact	0.23	medium_impact	0.53	0.8	27.36	21.95	0.43	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12376	12376	T	A	MI.19307	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	40	14	S	T	Tcc/Acc	-7.84	0	0	unknown	NA	neutral	0.55	neutral	3.82	neutral	0.33	neutral	0.79	neutral_impact	0.68	0.9	neutral	0.97	neutral	0.56	7.87	deleterious	0.39	0.5	NA	NA	0.04	neutral	0.08	neutral	0.17	neutral	7	0.45	neutral	0.78	deleterious	-4	neutral	0.10	neutral	2.1	high_impact	0.28	medium_impact	-0.58	medium_impact	0.70	0.85	27.36	21.95	0.48	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12377	12377	C	A	MI.19308	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	41	14	S	Y	tCc/tAc	-1.42	0	0	unknown	NA	neutral	0.18	neutral	3.74	neutral	-1.07	neutral	-0.37	medium_impact	2.12	0.82	neutral	0.69	neutral	1.05	10.96	neutral	0.32	0.5	NA	NA	0.2	neutral	0.35	neutral	0.21	neutral	6	0.82	neutral	0.59	deleterious	-1	neutral	0.19	neutral	2.1	high_impact	-0.13	medium_impact	0.73	medium_impact	0.55	0.8	27.36	21.95	0.43	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12377	12377	C	T	MI.19309	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	41	14	S	F	tCc/tTc	-1.42	0	0	unknown	NA	neutral	0.62	neutral	3.76	neutral	-0.24	neutral	0.42	low_impact	1.57	0.78	neutral	0.67	neutral	1.25	11.98	neutral	0.28	0.45	NA	NA	0.22	neutral	0.37	neutral	0.18	neutral	6	0.38	neutral	0.81	deleterious	-4	neutral	0.19	neutral	2.1	high_impact	0.35	medium_impact	0.23	medium_impact	0.43	0.8	27.36	21.95	0.27	N	0.47	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5928	5928	T	C	MI.1931	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	25	9	S	P	Tct/Cct	-3.11	0	0	probably_damaging	0.99	deleterious	0	neutral	-0.81	deleterious	-3.19	neutral	-0.78	medium_impact	3.34	0.43	damaging	0.21	damaging	3.77	23.40	deleterious	0.2	0.55	0.72	disease	0.81	disease	0.75	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-2.64	low_impact	-1.48	low_impact	1.99	medium_impact	0.55	0.9	1.17	6.83	0.51	N	0.91	disease_causing	0.82	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12377	12377	C	G	MI.19310	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	41	14	S	C	tCc/tGc	-1.42	0	0	unknown	NA	neutral	0.08	neutral	3.72	neutral	-1.76	neutral	-0.31	medium_impact	2.12	0.71	neutral	0.64	neutral	1.71	14.49	neutral	0.33	0.5	NA	NA	0.23	neutral	0.41	neutral	0.16	neutral	7	0.92	neutral	0.54	deleterious	-1	neutral	0.17	neutral	2.1	high_impact	-0.35	medium_impact	0.73	medium_impact	0.56	0.8	27.36	21.95	0.5	N	0.45	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12379	12379	C	A	MI.19311	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	43	15	L	M	Cta/Ata	-8.53	0	0	unknown	NA	neutral	0.19	neutral	3.26	deleterious	-7.85	neutral	-1.89	medium_impact	2.49	0.64	neutral	0.26	damaging	1.85	15.30	deleterious	0.29	0.45	NA	NA	0.23	neutral	0.25	neutral	0.2	neutral	6	0.81	neutral	0.6	deleterious	-1	neutral	0.30	neutral	2.1	high_impact	-0.12	medium_impact	1.07	medium_impact	0.75	0.85	8.29	7.07	0.37	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12379	12379	C	G	MI.19312	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	43	15	L	V	Cta/Gta	-8.53	0	0	unknown	NA	neutral	0.26	neutral	3.35	deleterious	-7.52	deleterious	-2.75	medium_impact	3.04	0.65	neutral	0.27	damaging	1.57	13.70	neutral	0.29	0.45	NA	NA	0.21	neutral	0.25	neutral	0.21	neutral	6	0.74	neutral	0.63	deleterious	-1	neutral	0.31	neutral	2.1	high_impact	-0.02	medium_impact	1.57	medium_impact	0.50	0.8	8.29	7.07	0.37	N	0.78	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12380	12380	T	G	MI.19313	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	44	15	L	R	cTa/cGa	-0.5	0	0	unknown	NA	neutral	0.05	neutral	3.21	deleterious	-10.26	deleterious	-5.57	medium_impact	3.04	0.55	damaging	0.13	damaging	2.30	18.17	deleterious	0.21	0.45	NA	NA	0.64	disease	0.74	disease	0.72	disease	4	0.95	neutral	0.53	deleterious	-1	neutral	0.52	deleterious	2.1	high_impact	-0.47	medium_impact	1.57	medium_impact	0.40	0.8	8.29	7.07	0.28	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12380	12380	T	A	MI.19314	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	44	15	L	Q	cTa/cAa	-0.5	0	0	unknown	NA	deleterious	0.04	neutral	3.21	deleterious	-10.41	deleterious	-5.57	medium_impact	3.04	0.56	damaging	0.14	damaging	2.22	17.64	deleterious	0.22	0.45	NA	NA	0.52	disease	0.62	disease	0.64	disease	3	0.96	neutral	0.52	deleterious	3	deleterious	0.39	neutral	2.1	high_impact	-0.53	medium_impact	1.57	medium_impact	0.50	0.8	8.29	7.07	0.29	N	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12380	12380	T	C	MI.19315	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	44	15	L	P	cTa/cCa	-0.5	0	0	unknown	NA	neutral	0.06	neutral	3.2	deleterious	-10.6	deleterious	-5.74	medium_impact	3.04	0.49	damaging	0.13	damaging	2.05	16.53	deleterious	0.26	0.45	NA	NA	0.52	disease	0.74	disease	0.72	disease	4	0.94	neutral	0.53	deleterious	-1	neutral	0.55	deleterious	2.1	high_impact	-0.43	medium_impact	1.57	medium_impact	0.44	0.8	8.29	7.07	0.3	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12382	12382	A	C	MI.19316	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	46	16	I	L	Att/Ctt	-5.78	0	0	unknown	NA	neutral	1	neutral	3.85	neutral	-0.9	neutral	-0.04	neutral_impact	0.53	0.86	neutral	0.97	neutral	-0.48	0.24	neutral	0.36	0.5	NA	NA	0.11	neutral	0.08	neutral	0.2	neutral	6	0	neutral	1	deleterious	-4	neutral	0.17	neutral	2.1	high_impact	1.89	high_impact	-0.72	medium_impact	0.31	0.8	11.94	9.03	0.34	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12382	12382	A	G	MI.19317	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	46	16	I	V	Att/Gtt	-5.78	0	0	unknown	NA	neutral	0.35	neutral	3.77	neutral	-0.53	neutral	-0.11	low_impact	1.26	0.89	neutral	0.95	neutral	-0.74	0.06	neutral	0.47	0.55	NA	NA	0.06	neutral	0.15	neutral	0.2	neutral	6	0.65	neutral	0.68	deleterious	-4	neutral	0.15	neutral	2.1	high_impact	0.08	medium_impact	-0.05	medium_impact	0.17	0.8	11.94	9.03	0.57	P	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12382	12382	A	T	MI.19318	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	46	16	I	F	Att/Ttt	-5.78	0	0	unknown	NA	neutral	0.98	neutral	3.68	neutral	-2.88	neutral	-1.99	low_impact	1.36	0.88	neutral	0.88	neutral	-0.22	0.99	neutral	0.38	0.5	NA	NA	0.27	neutral	0.15	neutral	0.18	neutral	6	0.02	neutral	0.99	deleterious	-4	neutral	0.22	neutral	2.1	high_impact	1.17	medium_impact	0.04	medium_impact	0.29	0.8	11.94	9.03	0.3	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12383	12383	T	G	MI.19319	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	47	16	I	S	aTt/aGt	-2.8	0	0	unknown	NA	neutral	0.36	neutral	3.66	neutral	-2.64	neutral	-2.01	low_impact	1.36	0.89	neutral	0.89	neutral	0.85	9.77	deleterious	0.27	0.45	NA	NA	0.42	neutral	0.22	neutral	0.21	neutral	6	0.64	neutral	0.68	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	0.1	medium_impact	0.04	medium_impact	0.31	0.8	11.94	9.03	0.37	N	0.35	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5928	5928	T	G	MI.1932	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	25	9	S	A	Tct/Gct	-3.11	0	0	probably_damaging	0.95	neutral	0.05	neutral	-0.75	neutral	-0.86	neutral	-0.47	medium_impact	2.67	0.64	neutral	0.2	damaging	3.46	23.00	deleterious	0.28	0.55	0.18	neutral	0.59	disease	0.68	disease	0.58	disease	2	0.99	deleterious	0.05	neutral	1	deleterious	0.62	deleterious	-1.96	low_impact	-0.52	medium_impact	1.37	medium_impact	0.64	0.9	1.17	6.83	0.38	N	0.33	polymorphism	0.82	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12383	12383	T	A	MI.19320	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	47	16	I	N	aTt/aAt	-2.8	0	0	unknown	NA	neutral	0.15	neutral	3.62	deleterious	-3.82	deleterious	-3.03	low_impact	1.82	0.75	neutral	0.56	neutral	1.22	11.83	neutral	0.26	0.45	NA	NA	0.44	neutral	0.48	neutral	0.24	neutral	5	0.85	neutral	0.58	deleterious	-4	neutral	0.31	neutral	2.1	high_impact	-0.18	medium_impact	0.46	medium_impact	0.42	0.8	11.94	9.03	0.4	N	0.53	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12383	12383	T	C	MI.19321	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	47	16	I	T	aTt/aCt	-2.8	0	0	unknown	NA	neutral	0.44	neutral	3.7	neutral	2.01	neutral	-0.12	neutral_impact	0.01	0.92	neutral	0.97	neutral	-0.85	0.03	neutral	0.27	0.45	NA	NA	0.11	neutral	0.16	neutral	0.23	neutral	5	0.56	neutral	0.72	deleterious	-4	neutral	0.20	neutral	2.1	high_impact	0.18	medium_impact	-1.19	low_impact	0.22	0.8	11.94	9.03	0.47	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12384	12384	T	A	MI.19322	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	48	16	I	M	atT/atA	-4.17	0	0.01	unknown	NA	neutral	0.36	neutral	3.66	neutral	-2.28	neutral	-0.3	low_impact	1.36	0.87	neutral	0.94	neutral	0.32	5.89	deleterious	0.44	0.55	NA	NA	0.13	neutral	0.13	neutral	0.23	neutral	5	0.64	neutral	0.68	deleterious	-4	neutral	0.24	neutral	2.1	high_impact	0.1	medium_impact	0.04	medium_impact	0.30	0.8	11.94	9.03	0.54	P	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12384	12384	T	G	MI.19323	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	48	16	I	M	atT/atG	-4.17	0	0.01	unknown	NA	neutral	0.36	neutral	3.66	neutral	-2.28	neutral	-0.3	low_impact	1.36	0.87	neutral	0.94	neutral	0.05	3.03	deleterious	0.44	0.55	NA	NA	0.13	neutral	0.13	neutral	0.23	neutral	5	0.64	neutral	0.68	deleterious	-4	neutral	0.24	neutral	2.1	high_impact	0.1	medium_impact	0.04	medium_impact	0.30	0.8	11.94	9.03	0.53	P	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12385	12385	C	T	MI.19324	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	49	17	P	S	Ccc/Tcc	-15.41	0	0	unknown	NA	neutral	0.39	neutral	3.82	neutral	1.46	neutral	0.99	low_impact	0.9	0.95	neutral	0.95	neutral	0.47	7.17	deleterious	0.33	0.5	NA	NA	0.07	neutral	0.24	neutral	0.2	neutral	6	0.61	neutral	0.7	deleterious	-4	neutral	0.09	neutral	2.1	high_impact	0.13	medium_impact	-0.38	medium_impact	0.24	0.8	21.39	11.59	0.45	N	0.15	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12385	12385	C	A	MI.19325	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	49	17	P	T	Ccc/Acc	-15.41	0	0	unknown	NA	neutral	0.5	neutral	3.83	neutral	2.53	neutral	1.92	neutral_impact	0.5	0.9	neutral	0.93	neutral	0.25	5.25	deleterious	0.3	0.45	NA	NA	0.04	neutral	0.22	neutral	0.18	neutral	6	0.5	neutral	0.75	deleterious	-4	neutral	0.10	neutral	2.1	high_impact	0.23	medium_impact	-0.75	medium_impact	0.48	0.8	21.39	11.59	0.39	N	0.06	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12385	12385	C	G	MI.19326	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	49	17	P	A	Ccc/Gcc	-15.41	0	0	unknown	NA	neutral	0.29	neutral	3.87	neutral	2.72	neutral	1.47	low_impact	1.01	0.9	neutral	0.93	neutral	-0.41	0.36	neutral	0.26	0.45	NA	NA	0.03	neutral	0.26	neutral	0.18	neutral	6	0.71	neutral	0.65	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	0.02	medium_impact	-0.28	medium_impact	0.51	0.8	21.39	11.59	0.46	N	0.34	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12386	12386	C	A	MI.19327	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	50	17	P	H	cCc/cAc	-4.63	0	0	unknown	NA	neutral	0.17	neutral	3.77	neutral	-0.03	neutral	0.03	low_impact	1.7	0.78	neutral	0.75	neutral	0.51	7.48	deleterious	0.28	0.45	NA	NA	0.13	neutral	0.56	disease	0.23	neutral	5	0.83	neutral	0.59	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	-0.15	medium_impact	0.35	medium_impact	0.36	0.8	21.39	11.59	0.43	N	0.63	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12386	12386	C	G	MI.19328	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	50	17	P	R	cCc/cGc	-4.63	0	0	unknown	NA	neutral	0.11	neutral	3.78	neutral	0.54	neutral	0.17	low_impact	1.36	0.79	neutral	0.71	neutral	0.39	6.56	deleterious	0.25	0.45	NA	NA	0.2	neutral	0.61	disease	0.3	neutral	4	0.89	neutral	0.56	deleterious	-4	neutral	0.21	neutral	2.1	high_impact	-0.27	medium_impact	0.04	medium_impact	0.42	0.8	21.39	11.59	0.41	N	0.64	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12386	12386	C	T	MI.19329	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	50	17	P	L	cCc/cTc	-4.63	0	0	unknown	NA	neutral	1	neutral	3.91	neutral	5.4	neutral	3.64	neutral_impact	-0.6	0.88	neutral	0.97	neutral	0.29	5.63	deleterious	0.28	0.45	NA	NA	0.07	neutral	0.22	neutral	0.21	neutral	6	0	neutral	1	deleterious	-4	neutral	0.13	neutral	2.1	high_impact	1.89	high_impact	-1.75	low_impact	0.82	0.85	21.39	11.59	0.28	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5929	5929	C	T	MI.1933	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	26	9	S	F	tCt/tTt	4.75	1	0	probably_damaging	1	deleterious	0	neutral	-0.82	deleterious	-3.53	neutral	-0.93	high_impact	3.69	0.39	damaging	0.12	damaging	3.98	23.60	deleterious	0.14	0.55	0.8	disease	0.86	disease	0.76	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.31	high_impact	0.37	0.9	1.17	6.83	0.69	P	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12388	12388	C	G	MI.19330	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	52	18	P	A	Ccc/Gcc	-9.91	0	0	unknown	NA	neutral	0.09	neutral	3.72	deleterious	-10.67	deleterious	-6.54	medium_impact	3.16	0.66	neutral	0.56	neutral	1.27	12.10	neutral	0.37	0.5	NA	NA	0.36	neutral	0.42	neutral	0.17	neutral	7	0.91	neutral	0.55	deleterious	-1	neutral	0.34	neutral	2.1	high_impact	-0.32	medium_impact	1.68	medium_impact	0.70	0.85	27.36	7.17	0.43	N	0.71	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12388	12388	C	T	MI.19331	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	52	18	P	S	Ccc/Tcc	-9.91	0	0	unknown	NA	neutral	0.15	neutral	3.68	deleterious	-10.99	deleterious	-6.66	medium_impact	2.61	0.66	neutral	0.57	neutral	2.09	16.78	deleterious	0.4	0.5	NA	NA	0.6	disease	0.24	neutral	0.48	neutral	1	0.85	neutral	0.58	deleterious	-1	neutral	0.43	neutral	2.1	high_impact	-0.18	medium_impact	1.18	medium_impact	0.29	0.8	27.36	7.17	0.38	N	0.75	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12388	12388	C	A	MI.19332	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	52	18	P	T	Ccc/Acc	-9.91	0	0	unknown	NA	neutral	0.18	neutral	3.68	deleterious	-11.42	deleterious	-6.31	medium_impact	2.82	0.71	neutral	0.51	neutral	1.86	15.33	deleterious	0.37	0.5	NA	NA	0.57	disease	0.24	neutral	0.51	disease	0	0.82	neutral	0.59	deleterious	-1	neutral	0.37	neutral	2.1	high_impact	-0.13	medium_impact	1.37	medium_impact	0.56	0.8	27.36	7.17	0.38	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12389	12389	C	A	MI.19333	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	53	18	P	H	cCc/cAc	1.56	0.23	0	unknown	NA	neutral	0.07	neutral	3.62	deleterious	-12.94	deleterious	-7.59	medium_impact	3.16	0.65	neutral	0.45	neutral	2.20	17.52	deleterious	0.34	0.5	NA	NA	0.71	disease	0.39	neutral	0.53	disease	1	0.93	neutral	0.54	deleterious	-1	neutral	0.49	deleterious	2.1	high_impact	-0.39	medium_impact	1.68	medium_impact	0.45	0.8	27.36	7.17	0.4	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12389	12389	C	G	MI.19334	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	53	18	P	R	cCc/cGc	1.56	0.23	0	unknown	NA	neutral	0.05	neutral	3.65	deleterious	-11.98	deleterious	-7.58	medium_impact	3.16	0.63	neutral	0.51	neutral	1.78	14.84	neutral	0.28	0.45	NA	NA	0.73	disease	0.64	disease	0.67	disease	3	0.95	neutral	0.53	deleterious	-1	neutral	0.48	deleterious	2.1	high_impact	-0.47	medium_impact	1.68	medium_impact	0.55	0.8	27.36	7.17	0.38	N	0.69	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12389	12389	C	T	MI.19335	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	53	18	P	L	cCc/cTc	1.56	0.23	0	unknown	NA	neutral	1	neutral	3.73	deleterious	-11.93	deleterious	-6.12	medium_impact	2.27	0.7	neutral	0.61	neutral	1.49	13.28	neutral	0.27	0.45	NA	NA	0.62	disease	0.26	neutral	0.4	neutral	2	0	neutral	1	deleterious	-1	neutral	0.39	neutral	2.1	high_impact	1.89	high_impact	0.87	medium_impact	0.77	0.85	27.36	7.17	0.26	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12391	12391	A	T	MI.19336	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	55	19	I	F	Atc/Ttc	-13.12	0	0	unknown	NA	neutral	0.69	neutral	3.56	deleterious	-6.88	deleterious	-3.35	medium_impact	2.42	0.75	neutral	0.69	neutral	2.02	16.35	deleterious	0.41	0.5	NA	NA	0.52	disease	0.43	neutral	0.49	neutral	0	0.31	neutral	0.85	deleterious	-1	neutral	0.32	neutral	2.1	high_impact	0.42	medium_impact	1.01	medium_impact	0.41	0.8	17.91	12.47	0.32	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12391	12391	A	G	MI.19337	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	55	19	I	V	Atc/Gtc	-13.12	0	0	unknown	NA	neutral	0.25	neutral	3.72	deleterious	-3.24	neutral	-0.69	low_impact	1.77	0.92	neutral	0.95	neutral	-0.20	1.12	neutral	0.48	0.55	NA	NA	0.09	neutral	0.16	neutral	0.22	neutral	6	0.75	neutral	0.63	deleterious	-4	neutral	0.16	neutral	2.1	high_impact	-0.03	medium_impact	0.41	medium_impact	0.24	0.8	17.91	12.47	0.57	P	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12391	12391	A	C	MI.19338	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	55	19	I	L	Atc/Ctc	-13.12	0	0	unknown	NA	neutral	1	neutral	3.9	deleterious	-4.29	neutral	-1.35	low_impact	1.18	0.85	neutral	0.91	neutral	-0.09	1.77	neutral	0.34	0.5	NA	NA	0.14	neutral	0.16	neutral	0.26	neutral	5	0	neutral	1	deleterious	-4	neutral	0.19	neutral	2.1	high_impact	1.89	high_impact	-0.13	medium_impact	0.34	0.8	17.91	12.47	0.32	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12392	12392	T	A	MI.19339	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	56	19	I	N	aTc/aAc	0.18	0	0	unknown	NA	neutral	0.12	neutral	3.5	deleterious	-8.6	deleterious	-5.86	medium_impact	2.96	0.73	neutral	0.53	neutral	2.61	20.30	deleterious	0.29	0.45	NA	NA	0.68	disease	0.57	disease	0.72	disease	4	0.88	neutral	0.56	deleterious	-1	neutral	0.46	deleterious	2.1	high_impact	-0.25	medium_impact	1.5	medium_impact	0.40	0.8	17.91	12.47	0.38	N	0.97	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5929	5929	C	G	MI.1934	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	26	9	S	C	tCt/tGt	4.75	1	0	probably_damaging	1	deleterious	0	neutral	-0.82	neutral	0.51	neutral	-0.78	medium_impact	3.27	0.52	damaging	0.15	damaging	3.39	23.00	deleterious	0.2	0.55	0.61	disease	0.79	disease	0.72	disease	0.74	disease	5	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	1.92	medium_impact	0.67	0.9	1.17	6.83	0.49	P	0.84	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12392	12392	T	G	MI.19340	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	56	19	I	S	aTc/aGc	0.18	0	0	unknown	NA	neutral	0.44	neutral	3.52	deleterious	-7.5	deleterious	-4.94	medium_impact	2.96	0.77	neutral	0.56	neutral	2.48	19.36	deleterious	0.34	0.5	NA	NA	0.68	disease	0.48	neutral	0.53	disease	1	0.56	neutral	0.72	deleterious	-1	neutral	0.41	neutral	2.1	high_impact	0.18	medium_impact	1.5	medium_impact	0.34	0.8	17.91	12.47	0.36	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12392	12392	T	C	MI.19341	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	56	19	I	T	aTc/aCc	0.18	0	0	unknown	NA	neutral	0.33	neutral	3.55	deleterious	-5.33	deleterious	-3.64	medium_impact	2.27	0.87	neutral	0.72	neutral	1.53	13.46	neutral	0.34	0.5	NA	NA	0.41	neutral	0.26	neutral	0.21	neutral	6	0.67	neutral	0.67	deleterious	-1	neutral	0.35	neutral	2.1	high_impact	0.06	medium_impact	0.87	medium_impact	0.31	0.8	17.91	12.47	0.43	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12393	12393	C	G	MI.19342	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	57	19	I	M	atC/atG	3.63	0.35	0	unknown	NA	neutral	0.25	neutral	3.54	deleterious	-6.51	neutral	-2	medium_impact	2.16	0.85	neutral	0.87	neutral	0.48	7.27	deleterious	0.57	0.65	NA	NA	0.31	neutral	0.2	neutral	0.21	neutral	6	0.75	neutral	0.63	deleterious	-1	neutral	0.31	neutral	2.1	high_impact	-0.03	medium_impact	0.77	medium_impact	0.56	0.8	17.91	12.47	0.41	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12393	12393	C	A	MI.19343	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	57	19	I	M	atC/atA	3.63	0.35	0	unknown	NA	neutral	0.25	neutral	3.54	deleterious	-6.51	neutral	-2	medium_impact	2.16	0.85	neutral	0.87	neutral	0.95	10.40	neutral	0.57	0.65	NA	NA	0.31	neutral	0.2	neutral	0.21	neutral	6	0.75	neutral	0.63	deleterious	-1	neutral	0.31	neutral	2.1	high_impact	-0.03	medium_impact	0.77	medium_impact	0.56	0.8	17.91	12.47	0.41	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12394	12394	C	A	MI.19344	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	58	20	L	I	Ctt/Att	-7.61	0	0	unknown	NA	neutral	0.58	neutral	3.66	neutral	1.23	neutral	-0.24	neutral_impact	0.3	0.89	neutral	0.98	neutral	0.11	3.71	deleterious	0.47	0.55	NA	NA	0.06	neutral	0.12	neutral	0.23	neutral	5	0.42	neutral	0.79	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	0.31	medium_impact	-0.93	medium_impact	0.63	0.8	13.1	10.78	0.48	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12394	12394	C	T	MI.19345	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	58	20	L	F	Ctt/Ttt	-7.61	0	0	unknown	NA	neutral	0.73	neutral	3.56	neutral	-1.84	neutral	-1.94	low_impact	0.85	0.89	neutral	0.86	neutral	0.86	9.81	deleterious	0.63	0.7	NA	NA	0.24	neutral	0.22	neutral	0.21	neutral	6	0.27	neutral	0.87	deleterious	-4	neutral	0.33	neutral	2.1	high_impact	0.47	medium_impact	-0.43	medium_impact	0.56	0.8	13.1	10.78	0.23	N	0.04	polymorphism	1	0.03	rs28709525	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12394	12394	C	G	MI.19346	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	58	20	L	V	Ctt/Gtt	-7.61	0	0	unknown	NA	neutral	0.41	neutral	3.64	neutral	-0.18	neutral	-0.65	low_impact	1.26	0.87	neutral	0.95	neutral	0.12	3.83	deleterious	0.54	0.6	NA	NA	0.2	neutral	0.17	neutral	0.22	neutral	6	0.59	neutral	0.71	deleterious	-4	neutral	0.32	neutral	2.1	high_impact	0.15	medium_impact	-0.05	medium_impact	0.54	0.8	13.1	10.78	0.47	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12395	12395	T	A	MI.19347	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	59	20	L	H	cTt/cAt	-5.09	0	0	unknown	NA	neutral	0.28	neutral	3.49	deleterious	-4.7	deleterious	-4.19	medium_impact	2.23	0.68	neutral	0.55	neutral	2.28	18.03	deleterious	0.27	0.45	NA	NA	0.56	disease	0.5	neutral	0.54	disease	1	0.72	neutral	0.64	deleterious	-1	neutral	0.44	deleterious	2.1	high_impact	0.01	medium_impact	0.83	medium_impact	0.48	0.8	13.1	10.78	0.37	N	0.61	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12395	12395	T	G	MI.19348	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	59	20	L	R	cTt/cGt	-5.09	0	0	unknown	NA	neutral	0.21	neutral	3.5	deleterious	-4.04	deleterious	-3.72	medium_impact	2.23	0.65	neutral	0.52	neutral	2.33	18.38	deleterious	0.3	0.45	NA	NA	0.7	disease	0.68	disease	0.74	disease	5	0.79	neutral	0.61	deleterious	-1	neutral	0.55	deleterious	2.1	high_impact	-0.09	medium_impact	0.83	medium_impact	0.49	0.8	13.1	10.78	0.32	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12395	12395	T	C	MI.19349	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	59	20	L	P	cTt/cCt	-5.09	0	0	unknown	NA	neutral	0.2	neutral	3.49	deleterious	-4.51	deleterious	-3.65	medium_impact	2.23	0.59	damaging	0.43	neutral	1.96	15.93	deleterious	0.44	0.55	NA	NA	0.72	disease	0.63	disease	0.73	disease	5	0.8	neutral	0.6	deleterious	-1	neutral	0.62	deleterious	2.1	high_impact	-0.1	medium_impact	0.83	medium_impact	0.41	0.8	13.1	10.78	0.31	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5929	5929	C	A	MI.1935	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	26	9	S	Y	tCt/tAt	4.75	1	0	probably_damaging	1	deleterious	0	neutral	-0.82	deleterious	-3.89	neutral	-0.93	high_impact	3.69	0.55	damaging	0.15	damaging	3.82	23.40	deleterious	0.15	0.55	0.82	disease	0.86	disease	0.76	disease	0.83	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.31	high_impact	0.61	0.9	1.17	6.83	0.49	P	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12397	12397	A	C	MI.19350	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	61	21	T	P	Acc/Ccc	-20	0	0.01	unknown	NA	neutral	0.36	neutral	3.69	deleterious	-3.09	neutral	-1.52	low_impact	1.15	0.74	neutral	0.71	neutral	0.43	6.85	deleterious	0.42	0.55	NA	NA	0.59	disease	0.25	neutral	0.47	neutral	1	0.64	neutral	0.68	deleterious	-4	neutral	0.43	neutral	2.1	high_impact	0.1	medium_impact	-0.15	medium_impact	0.70	0.85	27.69	13.06	0.38	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12397	12397	A	G	MI.19351	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	61	21	T	A	Acc/Gcc	-20	0	0.01	unknown	NA	neutral	0.46	neutral	3.81	neutral	-0.2	neutral	-0.74	neutral_impact	-0.74	0.88	neutral	0.94	neutral	0.01	2.70	deleterious	0.66	0.7	NA	NA	0.16	neutral	0.17	neutral	0.26	neutral	5	0.54	neutral	0.73	deleterious	-4	neutral	0.26	neutral	2.1	high_impact	0.19	medium_impact	-1.88	low_impact	0.32	0.8	27.69	13.06	0.5	N	0.02	polymorphism	1	0.01	rs200890363	risk_factor	Parkinson_disease_6,_autosomal_recessive_early-onset	24744	MedGen:C1853833,OMIM:605909	.	.	.	.	A12397G	PD, early onset	+	-	Reported	2	N	P	N,P	neutral
chrM	12397	12397	A	T	MI.19352	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	61	21	T	S	Acc/Tcc	-20	0	0.01	unknown	NA	neutral	0.43	neutral	3.77	neutral	-1.18	neutral	-1.08	low_impact	1.15	0.86	neutral	0.95	neutral	-0.09	1.80	neutral	0.68	0.7	NA	NA	0.18	neutral	0.29	neutral	0.24	neutral	5	0.57	neutral	0.72	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	0.17	medium_impact	-0.15	medium_impact	0.61	0.8	27.69	13.06	0.41	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12398	12398	C	G	MI.19353	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	62	21	T	S	aCc/aGc	-7.16	0	0	unknown	NA	neutral	0.43	neutral	3.77	neutral	-1.18	neutral	-1.08	low_impact	1.15	0.86	neutral	0.95	neutral	0.12	3.84	deleterious	0.68	0.7	NA	NA	0.18	neutral	0.29	neutral	0.24	neutral	5	0.57	neutral	0.72	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	0.17	medium_impact	-0.15	medium_impact	0.61	0.8	27.69	13.06	0.4	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12398	12398	C	A	MI.19354	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	62	21	T	N	aCc/aAc	-7.16	0	0	unknown	NA	neutral	0.33	neutral	3.7	neutral	-2.71	neutral	-2	neutral_impact	0.7	0.79	neutral	0.74	neutral	0.47	7.16	deleterious	0.73	0.75	NA	NA	0.39	neutral	0.42	neutral	0.2	neutral	6	0.67	neutral	0.67	deleterious	-4	neutral	0.30	neutral	2.1	high_impact	0.06	medium_impact	-0.56	medium_impact	0.72	0.85	27.69	13.06	0.33	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12398	12398	C	T	MI.19355	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	62	21	T	I	aCc/aTc	-7.16	0	0	unknown	NA	neutral	0.46	neutral	3.78	neutral	-0.25	neutral	0.38	neutral_impact	0.26	0.86	neutral	0.9	neutral	0.47	7.18	deleterious	0.62	0.65	NA	NA	0.29	neutral	0.16	neutral	0.21	neutral	6	0.54	neutral	0.73	deleterious	-4	neutral	0.29	neutral	2.1	high_impact	0.19	medium_impact	-0.97	medium_impact	0.53	0.8	27.69	13.06	0.43	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12400	12400	A	T	MI.19356	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	64	22	T	S	Acc/Tcc	-1.65	0	0	unknown	NA	neutral	0.52	neutral	3.78	neutral	-0.67	neutral	0.23	low_impact	0.96	0.84	neutral	0.96	neutral	0.05	3.11	deleterious	0.72	0.75	NA	NA	0.13	neutral	0.16	neutral	0.24	neutral	5	0.48	neutral	0.76	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	0.25	medium_impact	-0.33	medium_impact	0.65	0.8	21.23	15.61	0.43	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12400	12400	A	C	MI.19357	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	64	22	T	P	Acc/Ccc	-1.65	0	0	unknown	NA	neutral	0.35	neutral	3.69	deleterious	-4.49	neutral	-2.06	low_impact	1.62	0.82	neutral	0.91	neutral	1.02	10.78	neutral	0.39	0.5	NA	NA	0.42	neutral	0.3	neutral	0.21	neutral	6	0.65	neutral	0.68	deleterious	-4	neutral	0.35	neutral	2.1	high_impact	0.08	medium_impact	0.28	medium_impact	0.63	0.8	21.23	15.61	0.4	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12400	12400	A	G	MI.19358	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	64	22	T	A	Acc/Gcc	-1.65	0	0	unknown	NA	neutral	0.51	neutral	3.78	neutral	-2.23	neutral	-1.5	low_impact	1	0.84	neutral	0.88	neutral	1.03	10.81	neutral	0.71	0.75	NA	NA	0.18	neutral	0.38	neutral	0.21	neutral	6	0.49	neutral	0.76	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	0.24	medium_impact	-0.29	medium_impact	0.25	0.8	21.23	15.61	0.31	N	0.00	polymorphism	1	0.03	rs201405598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12401	12401	C	G	MI.19359	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	65	22	T	S	aCc/aGc	-4.17	0	0	unknown	NA	neutral	0.52	neutral	3.78	neutral	-0.67	neutral	0.23	low_impact	0.96	0.84	neutral	0.96	neutral	-0.21	1.03	neutral	0.72	0.75	NA	NA	0.13	neutral	0.16	neutral	0.24	neutral	5	0.48	neutral	0.76	deleterious	-4	neutral	0.25	neutral	2.1	high_impact	0.25	medium_impact	-0.33	medium_impact	0.65	0.8	21.23	15.61	0.43	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5931	5931	A	C	MI.1936	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	28	10	T	P	Aca/Cca	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	-0.84	neutral	-2.85	neutral	-0.94	high_impact	4.33	0.57	damaging	0.17	damaging	3.31	22.90	deleterious	0.11	0.55	0.71	disease	0.84	disease	0.75	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.9	high_impact	0.50	0.9	2.34	6.72	0.43	N	0.91	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12401	12401	C	T	MI.19360	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	65	22	T	I	aCc/aTc	-4.17	0	0	unknown	NA	neutral	0.55	neutral	3.74	neutral	-2.75	deleterious	-3.1	medium_impact	2.24	0.81	neutral	0.88	neutral	2.08	16.74	deleterious	0.53	0.6	NA	NA	0.37	neutral	0.24	neutral	0.21	neutral	6	0.45	neutral	0.78	deleterious	-1	neutral	0.28	neutral	2.1	high_impact	0.28	medium_impact	0.84	medium_impact	0.55	0.8	21.23	15.61	0.29	N	0.40	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12401	12401	C	A	MI.19361	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	65	22	T	N	aCc/aAc	-4.17	0	0	unknown	NA	neutral	0.35	neutral	3.71	deleterious	-3.1	neutral	-1.43	low_impact	1.9	0.81	neutral	0.86	neutral	0.45	7.07	deleterious	0.64	0.7	NA	NA	0.36	neutral	0.2	neutral	0.2	neutral	6	0.65	neutral	0.68	deleterious	-4	neutral	0.29	neutral	2.1	high_impact	0.08	medium_impact	0.53	medium_impact	0.64	0.8	21.23	15.61	0.4	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12403	12403	C	A	MI.19362	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	67	23	L	I	Ctc/Atc	-11.97	0	0.01	unknown	NA	neutral	0.6	neutral	3.62	neutral	-1.31	neutral	-0.41	medium_impact	2.44	0.86	neutral	0.97	neutral	0.88	9.92	deleterious	0.44	0.55	NA	NA	0.23	neutral	0.16	neutral	0.21	neutral	6	0.4	neutral	0.8	deleterious	-1	neutral	0.32	neutral	2.1	high_impact	0.33	medium_impact	1.03	medium_impact	0.68	0.85	22.06	19.72	0.44	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12403	12403	C	T	MI.19363	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	67	23	L	F	Ctc/Ttc	-11.97	0	0.01	unknown	NA	neutral	0.9	neutral	3.56	neutral	-1.67	neutral	-0.92	low_impact	1.63	0.86	neutral	0.94	neutral	0.63	8.39	deleterious	0.61	0.65	NA	NA	0.34	neutral	0.17	neutral	0.2	neutral	6	0.1	neutral	0.95	deleterious	-4	neutral	0.35	neutral	2.1	high_impact	0.76	medium_impact	0.29	medium_impact	0.52	0.8	22.06	19.72	0.37	N	0.29	polymorphism	1	0.02	rs879096684	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12403	12403	C	G	MI.19364	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	67	23	L	V	Ctc/Gtc	-11.97	0	0.01	unknown	NA	neutral	0.5	neutral	3.61	neutral	-0.63	neutral	-0.74	medium_impact	2.78	0.69	neutral	0.69	neutral	0.52	7.55	deleterious	0.52	0.6	NA	NA	0.36	neutral	0.34	neutral	0.19	neutral	6	0.5	neutral	0.75	deleterious	-1	neutral	0.34	neutral	2.1	high_impact	0.23	medium_impact	1.34	medium_impact	0.62	0.8	22.06	19.72	0.42	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12404	12404	T	C	MI.19365	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	68	23	L	P	cTc/cCc	-4.86	0	0	unknown	NA	neutral	0.25	neutral	3.48	neutral	-1.64	neutral	-1.84	medium_impact	2.23	0.8	neutral	0.74	neutral	1.01	10.70	neutral	0.3	0.45	NA	NA	0.74	disease	0.43	neutral	0.56	disease	1	0.75	neutral	0.63	deleterious	-1	neutral	0.60	deleterious	2.1	high_impact	-0.03	medium_impact	0.83	medium_impact	0.41	0.8	22.06	19.72	0.3	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12404	12404	T	A	MI.19366	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	68	23	L	H	cTc/cAc	-4.86	0	0	unknown	NA	neutral	0.42	neutral	3.48	neutral	-1.99	neutral	-1.99	medium_impact	2.78	0.74	neutral	0.59	neutral	1.20	11.74	neutral	0.36	0.5	NA	NA	0.65	disease	0.47	neutral	0.54	disease	1	0.58	neutral	0.71	deleterious	-1	neutral	0.49	deleterious	2.1	high_impact	0.16	medium_impact	1.34	medium_impact	0.54	0.8	22.06	19.72	0.31	N	0.75	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12404	12404	T	G	MI.19367	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	68	23	L	R	cTc/cGc	-4.86	0	0	unknown	NA	neutral	0.3	neutral	3.49	neutral	-0.94	neutral	-2.03	medium_impact	2.78	0.6	damaging	0.54	neutral	2.30	18.18	deleterious	0.25	0.45	NA	NA	0.75	disease	0.58	disease	0.69	disease	4	0.7	neutral	0.65	deleterious	-1	neutral	0.58	deleterious	2.1	high_impact	0.03	medium_impact	1.34	medium_impact	0.43	0.8	22.06	19.72	0.33	N	0.58	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12406	12406	G	A	MI.19368	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	70	24	V	I	Gtt/Att	-11.51	0	0.14	benign	0	neutral	0.43	neutral	3.82	neutral	-0.09	neutral	-0.39	neutral_impact	-0.34	0.86	neutral	0.96	neutral	-0.37	0.45	neutral	0.75	0.8	NA	NA	0.04	neutral	0.13	neutral	0.2	neutral	6	0.57	neutral	0.72	deleterious	-6	neutral	0.06	neutral	2.1	high_impact	0.17	medium_impact	-1.51	low_impact	0.84	0.9	24.71	20.09	0.51	N	0.00	polymorphism	1	0.00	rs28617389	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12406	12406	G	T	MI.19369	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	70	24	V	F	Gtt/Ttt	-11.51	0	0.14	benign	0.32	neutral	0.57	neutral	3.7	neutral	-0.53	neutral	-1.48	neutral_impact	0.78	0.83	neutral	0.95	neutral	0.07	3.32	deleterious	0.51	0.6	NA	NA	0.27	neutral	0.16	neutral	0.16	neutral	7	0.34	neutral	0.63	deleterious	-6	neutral	0.28	neutral	-0.44	medium_impact	0.3	medium_impact	-0.49	medium_impact	0.51	0.8	24.71	20.09	0.42	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5931	5931	A	G	MI.1937	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	28	10	T	A	Aca/Gca	-3.34	0	0	probably_damaging	0.97	deleterious	0	neutral	-0.79	neutral	-0.64	neutral	-0.8	medium_impact	3.43	0.9	neutral	0.17	damaging	3.28	22.80	deleterious	0.44	0.55	0.4	neutral	0.7	disease	0.74	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.69	deleterious	-2.18	low_impact	-1.48	low_impact	2.07	high_impact	0.43	0.9	2.34	6.72	0.42	N	0.65	disease_causing	0.95	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12406	12406	G	C	MI.19370	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	70	24	V	L	Gtt/Ctt	-11.51	0	0.14	benign	0.06	neutral	1	neutral	3.82	neutral	0.49	neutral	-0.43	low_impact	0.9	0.82	neutral	0.96	neutral	-0.54	0.18	neutral	0.66	0.7	NA	NA	0.1	neutral	0.1	neutral	0.22	neutral	6	0.06	neutral	0.97	deleterious	-6	neutral	0.08	neutral	0.39	medium_impact	1.89	high_impact	-0.38	medium_impact	0.58	0.8	24.71	20.09	0.38	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12407	12407	T	A	MI.19371	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	71	24	V	D	gTt/gAt	-2.34	0	0	possibly_damaging	0.74	neutral	0.12	neutral	3.64	neutral	-1.93	neutral	-1.58	low_impact	1.59	0.78	neutral	0.67	neutral	1.41	12.82	neutral	0.45	0.55	NA	NA	0.4	neutral	0.61	disease	0.31	neutral	4	0.91	neutral	0.19	neutral	-3	neutral	0.54	deleterious	-1.18	low_impact	-0.25	medium_impact	0.25	medium_impact	0.64	0.8	24.71	20.09	0.35	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12407	12407	T	C	MI.19372	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	71	24	V	A	gTt/gCt	-2.34	0	0	benign	0.15	neutral	0.27	neutral	3.74	neutral	-0.11	neutral	-0.15	low_impact	1.25	0.85	neutral	0.96	neutral	-0.15	1.41	neutral	0.67	0.7	NA	NA	0.09	neutral	0.37	neutral	0.24	neutral	5	0.69	neutral	0.56	deleterious	-6	neutral	0.18	neutral	-0.03	medium_impact	-0.01	medium_impact	-0.06	medium_impact	0.42	0.8	24.71	20.09	0.48	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12407	12407	T	G	MI.19373	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	71	24	V	G	gTt/gGt	-2.34	0	0	possibly_damaging	0.56	neutral	0.31	neutral	3.65	neutral	-1.78	neutral	-2.14	low_impact	1.25	0.74	neutral	0.65	neutral	0.58	8.02	deleterious	0.51	0.6	NA	NA	0.22	neutral	0.51	disease	0.21	neutral	6	0.69	neutral	0.38	neutral	-3	neutral	0.38	neutral	-0.85	medium_impact	0.04	medium_impact	-0.06	medium_impact	0.68	0.85	24.71	20.09	0.38	N	0.31	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12409	12409	A	G	MI.19374	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	73	25	N	D	Aac/Gac	-11.74	0	0	benign	0.08	neutral	0.21	neutral	3.75	neutral	-2.03	neutral	-2.16	medium_impact	2.16	0.84	neutral	0.94	neutral	0.45	7.02	deleterious	0.84	0.85	NA	NA	0.26	neutral	0.35	neutral	0.18	neutral	6	0.77	neutral	0.57	deleterious	-3	neutral	0.23	neutral	0.26	medium_impact	-0.09	medium_impact	0.77	medium_impact	0.44	0.8	25.21	13.1	0.47	N	0.70	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12409	12409	A	T	MI.19375	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	73	25	N	Y	Aac/Tac	-11.74	0	0	possibly_damaging	0.59	neutral	1	neutral	3.71	deleterious	-3.8	deleterious	-3.06	medium_impact	1.96	0.84	neutral	0.72	neutral	0.80	9.44	deleterious	0.57	0.65	NA	NA	0.41	neutral	0.33	neutral	0.18	neutral	6	0.59	neutral	0.71	deleterious	0	NA	0.56	deleterious	-0.9	medium_impact	1.89	high_impact	0.59	medium_impact	0.57	0.8	25.21	13.1	0.25	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12409	12409	A	C	MI.19376	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	73	25	N	H	Aac/Cac	-11.74	0	0	possibly_damaging	0.59	neutral	0.54	neutral	3.72	deleterious	-3.34	neutral	-2.2	medium_impact	2.5	0.79	neutral	0.79	neutral	0.16	4.24	deleterious	0.74	0.8	NA	NA	0.3	neutral	0.23	neutral	0.2	neutral	6	0.55	neutral	0.48	deleterious	0	NA	0.51	deleterious	-0.9	medium_impact	0.27	medium_impact	1.08	medium_impact	0.49	0.8	25.21	13.1	0.32	N	0.52	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12410	12410	A	G	MI.19377	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	74	25	N	S	aAc/aGc	-4.4	0	0	benign	0.01	neutral	0.45	neutral	3.82	neutral	-0.88	neutral	-1.7	low_impact	0.96	0.9	neutral	0.99	neutral	-0.63	0.11	neutral	0.81	0.85	NA	NA	0.12	neutral	0.16	neutral	0.23	neutral	5	0.54	neutral	0.72	deleterious	-6	neutral	0.10	neutral	1.15	medium_impact	0.18	medium_impact	-0.33	medium_impact	0.20	0.8	25.21	13.1	0.5	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12410	12410	A	T	MI.19378	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	74	25	N	I	aAc/aTc	-4.4	0	0	benign	0.28	neutral	0.42	neutral	3.73	deleterious	-3.86	deleterious	-4.29	medium_impact	2.16	0.81	neutral	0.65	neutral	0.89	10.01	neutral	0.55	0.6	NA	NA	0.39	neutral	0.18	neutral	0.21	neutral	6	0.49	neutral	0.57	deleterious	-3	neutral	0.45	deleterious	-0.36	medium_impact	0.16	medium_impact	0.77	medium_impact	0.51	0.8	25.21	13.1	0.43	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12410	12410	A	C	MI.19379	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	74	25	N	T	aAc/aCc	-4.4	0	0	benign	0.01	neutral	0.46	neutral	3.78	neutral	-1.52	neutral	-2.15	low_impact	1.47	0.89	neutral	0.96	neutral	-0.18	1.18	neutral	0.64	0.7	NA	NA	0.25	neutral	0.15	neutral	0.2	neutral	6	0.53	neutral	0.73	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.19	medium_impact	0.14	medium_impact	0.43	0.8	25.21	13.1	0.44	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5931	5931	A	T	MI.1938	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	28	10	T	S	Aca/Tca	-3.34	0	0	probably_damaging	0.97	neutral	0.11	neutral	-0.81	neutral	1.19	neutral	-0.64	medium_impact	2.69	0.67	neutral	0.17	damaging	3.20	22.70	deleterious	0.36	0.55	0.44	neutral	0.68	disease	0.62	disease	0.48	neutral	0	0.99	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-2.18	low_impact	-0.31	medium_impact	1.39	medium_impact	0.59	0.9	2.34	6.72	0.36	N	0.77	disease_causing	0.87	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12411	12411	C	A	MI.19380	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	75	25	N	K	aaC/aaA	-0.5	0	0	benign	0	neutral	0.33	neutral	3.83	neutral	-0.66	neutral	-2.04	low_impact	1.53	0.89	neutral	0.91	neutral	0.62	8.32	deleterious	0.84	0.85	NA	NA	0.25	neutral	0.38	neutral	0.17	neutral	7	0.67	neutral	0.67	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.06	medium_impact	0.2	medium_impact	0.56	0.8	25.21	13.1	0.42	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12411	12411	C	G	MI.19381	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	75	25	N	K	aaC/aaG	-0.5	0	0	benign	0	neutral	0.33	neutral	3.83	neutral	-0.66	neutral	-2.04	low_impact	1.53	0.89	neutral	0.91	neutral	0.19	4.54	deleterious	0.84	0.85	NA	NA	0.25	neutral	0.38	neutral	0.17	neutral	7	0.67	neutral	0.67	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.06	medium_impact	0.2	medium_impact	0.56	0.8	25.21	13.1	0.4	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12412	12412	C	G	MI.19382	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	76	26	P	A	Cct/Gct	-3.94	0	0	benign	0.31	neutral	0.51	neutral	3.78	neutral	1.06	neutral	0.75	medium_impact	2.5	0.81	neutral	0.86	neutral	-0.09	1.80	neutral	0.58	0.65	NA	NA	0.33	neutral	0.4	neutral	0.18	neutral	6	0.4	neutral	0.6	deleterious	-3	neutral	0.32	neutral	-0.42	medium_impact	0.24	medium_impact	1.08	medium_impact	0.76	0.85	23.71	19.47	0.32	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12412	12412	C	T	MI.19383	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	76	26	P	S	Cct/Tct	-3.94	0	0	benign	0.04	neutral	0.46	neutral	3.77	neutral	0.59	neutral	0.72	low_impact	1.61	0.85	neutral	0.91	neutral	0.69	8.79	deleterious	0.64	0.7	NA	NA	0.5	neutral	0.21	neutral	0.41	neutral	2	0.51	neutral	0.71	deleterious	-6	neutral	0.43	neutral	0.57	medium_impact	0.19	medium_impact	0.27	medium_impact	0.19	0.8	23.71	19.47	0.36	N	0.57	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12412	12412	C	A	MI.19384	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	76	26	P	T	Cct/Act	-3.94	0	0	benign	0.06	neutral	0.46	neutral	3.76	neutral	2.05	neutral	1.61	low_impact	1.12	0.87	neutral	0.96	neutral	0.31	5.81	deleterious	0.55	0.6	NA	NA	0.5	disease	0.2	neutral	0.41	neutral	2	0.49	neutral	0.7	deleterious	-6	neutral	0.12	neutral	0.39	medium_impact	0.19	medium_impact	-0.18	medium_impact	0.68	0.85	23.71	19.47	0.34	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12413	12413	C	A	MI.19385	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	77	26	P	H	cCt/cAt	-4.63	0	0	probably_damaging	0.94	neutral	0.54	neutral	3.7	neutral	-1.28	neutral	-0.29	medium_impact	2.16	0.77	neutral	0.63	neutral	2.48	19.33	deleterious	0.65	0.7	NA	NA	0.61	disease	0.33	neutral	0.52	disease	0	0.94	neutral	0.3	neutral	1	deleterious	0.71	deleterious	-1.88	low_impact	0.27	medium_impact	0.77	medium_impact	0.56	0.8	23.71	19.47	0.24	N	0.86	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12413	12413	C	G	MI.19386	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	77	26	P	R	cCt/cGt	-4.63	0	0	possibly_damaging	0.84	neutral	0.35	neutral	3.75	neutral	-0.57	neutral	-0.02	medium_impact	2.5	0.72	neutral	0.61	neutral	2.01	16.27	deleterious	0.49	0.55	NA	NA	0.66	disease	0.57	disease	0.62	disease	2	0.86	neutral	0.26	neutral	0	NA	0.63	deleterious	-1.43	low_impact	0.08	medium_impact	1.08	medium_impact	0.59	0.8	23.71	19.47	0.38	N	0.80	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12413	12413	C	T	MI.19387	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	77	26	P	L	cCt/cTt	-4.63	0	0	possibly_damaging	0.56	neutral	0.73	neutral	3.76	neutral	2.41	neutral	2.08	low_impact	1.09	0.8	neutral	0.9	neutral	0.87	9.89	deleterious	0.5	0.6	NA	NA	0.56	disease	0.24	neutral	0.44	neutral	1	0.47	neutral	0.59	deleterious	-3	neutral	0.42	neutral	-0.85	medium_impact	0.47	medium_impact	-0.21	medium_impact	0.72	0.85	23.71	19.47	0.26	N	0.24	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12415	12415	A	G	MI.19388	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	79	27	N	D	Aac/Gac	-10.6	0	0	benign	0.01	neutral	0.22	neutral	3.78	neutral	-0.56	neutral	-1.31	medium_impact	2.33	0.79	neutral	0.72	neutral	2.34	18.41	deleterious	0.83	0.85	NA	NA	0.29	neutral	0.37	neutral	0.17	neutral	7	0.78	neutral	0.61	deleterious	-3	neutral	0.68	deleterious	1.15	medium_impact	-0.07	medium_impact	0.93	medium_impact	0.73	0.85	28.52	20	0.44	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12415	12415	A	C	MI.19389	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	79	27	N	H	Aac/Cac	-10.6	0	0	benign	0.02	neutral	0.54	neutral	3.74	neutral	3	neutral	3.07	low_impact	1.64	0.82	neutral	0.99	neutral	0.84	9.69	deleterious	0.79	0.8	NA	NA	0.21	neutral	0.24	neutral	0.17	neutral	7	0.43	neutral	0.76	deleterious	-6	neutral	0.68	deleterious	0.86	medium_impact	0.27	medium_impact	0.3	medium_impact	0.72	0.85	28.52	20	0.35	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5932	5932	C	A	MI.1939	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	29	10	T	K	aCa/aAa	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	-0.84	neutral	-1.94	neutral	-0.96	high_impact	3.77	0.73	neutral	0.14	damaging	4.24	23.90	deleterious	0.18	0.55	0.59	disease	0.89	disease	0.77	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	2.38	high_impact	0.54	0.9	2.34	6.72	0.54	P	0.87	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12415	12415	A	T	MI.19390	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	79	27	N	Y	Aac/Tac	-10.6	0	0	benign	0.02	neutral	1	neutral	3.73	neutral	8	neutral	3.91	neutral_impact	0.55	0.88	neutral	0.96	neutral	0.82	9.62	deleterious	0.66	0.7	NA	NA	0.28	neutral	0.24	neutral	0.17	neutral	7	0.02	neutral	0.99	deleterious	-6	neutral	0.69	deleterious	0.86	medium_impact	1.89	high_impact	-0.7	medium_impact	0.75	0.85	28.52	20	0.29	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12416	12416	A	G	MI.19391	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	80	27	N	S	aAc/aGc	-2.8	0	0	benign	0.03	neutral	0.43	neutral	3.82	neutral	0.21	neutral	-0.7	medium_impact	1.98	0.86	neutral	0.85	neutral	1.25	11.99	neutral	0.86	0.9	NA	NA	0.22	neutral	0.19	neutral	0.18	neutral	6	0.54	neutral	0.7	deleterious	-3	neutral	0.68	deleterious	0.69	medium_impact	0.17	medium_impact	0.61	medium_impact	0.62	0.8	28.52	20	0.46	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12416	12416	A	C	MI.19392	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	80	27	N	T	aAc/aCc	-2.8	0	0	benign	0.25	neutral	0.4	neutral	3.8	neutral	-0.17	neutral	-0.75	low_impact	1.52	0.84	neutral	0.88	neutral	1.54	13.50	neutral	0.72	0.75	NA	NA	0.25	neutral	0.17	neutral	0.17	neutral	7	0.52	neutral	0.58	deleterious	-6	neutral	0.67	deleterious	-0.29	medium_impact	0.14	medium_impact	0.19	medium_impact	0.76	0.85	28.52	20	0.48	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12416	12416	A	T	MI.19393	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	80	27	N	I	aAc/aTc	-2.8	0	0	possibly_damaging	0.65	neutral	0.41	neutral	3.75	neutral	0.2	neutral	-0.89	medium_impact	2.33	0.85	neutral	0.91	neutral	2.10	16.88	deleterious	0.59	0.65	NA	NA	0.39	neutral	0.38	neutral	0.16	neutral	7	0.67	neutral	0.38	neutral	0	NA	0.70	deleterious	-1	low_impact	0.15	medium_impact	0.93	medium_impact	0.62	0.8	28.52	20	0.36	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12417	12417	C	G	MI.19394	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	81	27	N	K	aaC/aaG	-0.96	0	0	benign	0.25	neutral	0.3	neutral	3.83	neutral	0.43	neutral	-0.7	low_impact	1.64	0.78	neutral	0.76	neutral	2.24	17.76	deleterious	0.81	0.85	NA	NA	0.25	neutral	0.2	neutral	0.17	neutral	7	0.64	neutral	0.53	deleterious	-6	neutral	0.70	deleterious	-0.29	medium_impact	0.03	medium_impact	0.3	medium_impact	0.76	0.85	28.52	20	0.46	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12417	12417	C	A	MI.19395	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	81	27	N	K	aaC/aaA	-0.96	0	0	benign	0.25	neutral	0.3	neutral	3.83	neutral	0.43	neutral	-0.7	low_impact	1.64	0.78	neutral	0.76	neutral	2.72	20.90	deleterious	0.81	0.85	NA	NA	0.25	neutral	0.2	neutral	0.17	neutral	7	0.64	neutral	0.53	deleterious	-6	neutral	0.70	deleterious	-0.29	medium_impact	0.03	medium_impact	0.3	medium_impact	0.76	0.85	28.52	20	0.46	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12418	12418	A	G	MI.19396	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	82	28	K	E	Aaa/Gaa	-6.01	0	0	benign	0.03	neutral	0.34	neutral	3.74	deleterious	-3.32	neutral	-1.83	low_impact	1.23	0.84	neutral	0.77	neutral	0.44	6.95	deleterious	0.48	0.55	NA	NA	0.63	disease	0.51	disease	0.49	neutral	0	0.64	neutral	0.66	deleterious	-6	neutral	0.21	neutral	0.69	medium_impact	0.07	medium_impact	-0.08	medium_impact	0.68	0.85	6.47	9.42	0.34	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12418	12418	A	C	MI.19397	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	82	28	K	Q	Aaa/Caa	-6.01	0	0	possibly_damaging	0.56	neutral	0.34	neutral	3.71	deleterious	-3.51	neutral	-1.72	low_impact	1.48	0.81	neutral	0.84	neutral	0.09	3.52	deleterious	0.55	0.6	NA	NA	0.41	neutral	0.26	neutral	0.2	neutral	6	0.66	neutral	0.39	neutral	-3	neutral	0.44	deleterious	-0.85	medium_impact	0.07	medium_impact	0.15	medium_impact	0.79	0.85	6.47	9.42	0.37	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12419	12419	A	T	MI.19398	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	83	28	K	M	aAa/aTa	0.18	0	0	probably_damaging	0.94	neutral	0.23	neutral	3.65	deleterious	-5.96	deleterious	-3.03	medium_impact	2.23	0.8	neutral	0.73	neutral	3.63	23.20	deleterious	0.29	0.45	NA	NA	0.4	neutral	0.29	neutral	0.22	neutral	6	0.96	neutral	0.15	neutral	1	deleterious	0.69	deleterious	-1.88	low_impact	-0.06	medium_impact	0.83	medium_impact	0.48	0.8	6.47	9.42	0.41	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12419	12419	A	C	MI.19399	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	83	28	K	T	aAa/aCa	0.18	0	0	possibly_damaging	0.64	neutral	0.43	neutral	3.71	neutral	-2.89	neutral	-2.13	low_impact	1.43	0.84	neutral	0.95	neutral	0.69	8.76	deleterious	0.35	0.5	NA	NA	0.46	neutral	0.28	neutral	0.27	neutral	5	0.65	neutral	0.4	neutral	-3	neutral	0.52	deleterious	-0.98	medium_impact	0.17	medium_impact	0.1	medium_impact	0.54	0.8	6.47	9.42	0.35	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8617	8617	A	G	MI.194	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	91	31	I	V	Atc/Gtc	-2.65	0	0	benign	0	neutral	0.35	neutral	4.42	neutral	0.31	neutral	-0.71	low_impact	1.18	0.88	neutral	0.89	neutral	-0.12	1.58	neutral	0.57	0.65	0.43	neutral	0.23	neutral	0.33	neutral	0.43	neutral	1	0.65	neutral	0.68	deleterious	-6	neutral	0.15	neutral	2.09	high_impact	0.14	medium_impact	-0.09	medium_impact	0.19	0.9	28.32	22.32	0.4	N	0.00	polymorphism	1	0.01	.	.	.	.	.	acute leukemia platelets, leukocytes & bone marrow	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5932	5932	C	T	MI.1940	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	29	10	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	-0.85	deleterious	-3.54	neutral	-0.96	high_impact	3.63	0.83	neutral	0.14	damaging	3.82	23.40	deleterious	0.27	0.55	0.53	disease	0.83	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.25	high_impact	0.68	0.9	2.34	6.72	0.47	N	0.95	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12420	12420	A	C	MI.19400	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	84	28	K	N	aaA/aaC	0.18	0	0	benign	0.03	neutral	0.36	neutral	3.7	deleterious	-4.13	neutral	-0.97	low_impact	1.88	0.81	neutral	0.92	neutral	0.49	7.37	deleterious	0.61	0.65	NA	NA	0.4	neutral	0.27	neutral	0.2	neutral	6	0.62	neutral	0.67	deleterious	-6	neutral	0.52	deleterious	0.69	medium_impact	0.1	medium_impact	0.51	medium_impact	0.68	0.85	6.47	9.42	0.44	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12420	12420	A	T	MI.19401	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	84	28	K	N	aaA/aaT	0.18	0	0	benign	0.03	neutral	0.36	neutral	3.7	deleterious	-4.13	neutral	-0.97	low_impact	1.88	0.81	neutral	0.92	neutral	0.57	7.93	deleterious	0.61	0.65	NA	NA	0.4	neutral	0.27	neutral	0.2	neutral	6	0.62	neutral	0.67	deleterious	-6	neutral	0.52	deleterious	0.69	medium_impact	0.1	medium_impact	0.51	medium_impact	0.68	0.85	6.47	9.42	0.44	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12421	12421	A	G	MI.19402	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	85	29	K	E	Aaa/Gaa	-8.53	0	0	benign	0.12	neutral	0.31	neutral	3.74	neutral	-0.08	neutral	-0.42	medium_impact	1.99	0.77	neutral	0.71	neutral	1.43	12.95	neutral	0.46	0.55	NA	NA	0.48	neutral	0.45	neutral	0.34	neutral	3	0.64	neutral	0.6	deleterious	-3	neutral	0.73	deleterious	0.08	medium_impact	0.04	medium_impact	0.62	medium_impact	0.71	0.85	25.87	13.49	0.39	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12421	12421	A	C	MI.19403	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	85	29	K	Q	Aaa/Caa	-8.53	0	0	benign	0.3	neutral	0.32	neutral	3.7	neutral	-0.89	neutral	-0.36	medium_impact	2.19	0.78	neutral	0.89	neutral	1.17	11.58	neutral	0.51	0.6	NA	NA	0.22	neutral	0.23	neutral	0.16	neutral	7	0.61	neutral	0.51	deleterious	-3	neutral	0.69	deleterious	-0.4	medium_impact	0.05	medium_impact	0.8	medium_impact	0.73	0.85	25.87	13.49	0.44	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12422	12422	A	T	MI.19404	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	86	29	K	M	aAa/aTa	-1.65	0	0	possibly_damaging	0.83	neutral	0.23	neutral	3.62	deleterious	-3.06	neutral	-1.36	low_impact	1.84	0.78	neutral	0.7	neutral	2.30	18.14	deleterious	0.36	0.5	NA	NA	0.25	neutral	0.31	neutral	0.17	neutral	7	0.89	neutral	0.2	neutral	-3	neutral	0.70	deleterious	-1.4	low_impact	-0.06	medium_impact	0.48	medium_impact	0.62	0.8	25.87	13.49	0.4	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12422	12422	A	C	MI.19405	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	86	29	K	T	aAa/aCa	-1.65	0	0	benign	0.01	neutral	0.42	neutral	3.69	neutral	1.28	neutral	0.5	low_impact	1.06	0.83	neutral	0.99	neutral	0.79	9.41	deleterious	0.35	0.5	NA	NA	0.25	neutral	0.26	neutral	0.18	neutral	6	0.57	neutral	0.71	deleterious	-6	neutral	0.70	deleterious	1.15	medium_impact	0.16	medium_impact	-0.23	medium_impact	0.66	0.8	25.87	13.49	0.43	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12423	12423	A	C	MI.19406	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	87	29	K	N	aaA/aaC	-6.24	0	0	benign	0	neutral	0.34	neutral	3.69	neutral	1.46	neutral	1.83	low_impact	0.97	0.84	neutral	0.99	neutral	1.25	11.99	neutral	0.54	0.6	NA	NA	0.24	neutral	0.28	neutral	0.17	neutral	7	0.66	neutral	0.67	deleterious	-6	neutral	0.71	deleterious	2.1	high_impact	0.07	medium_impact	-0.32	medium_impact	0.76	0.85	25.87	13.49	0.39	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12423	12423	A	T	MI.19407	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	87	29	K	N	aaA/aaT	-6.24	0	0	benign	0	neutral	0.34	neutral	3.69	neutral	1.46	neutral	1.83	low_impact	0.97	0.84	neutral	0.99	neutral	1.32	12.39	neutral	0.54	0.6	NA	NA	0.24	neutral	0.28	neutral	0.17	neutral	7	0.66	neutral	0.67	deleterious	-6	neutral	0.71	deleterious	2.1	high_impact	0.07	medium_impact	-0.32	medium_impact	0.76	0.85	25.87	13.49	0.4	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12424	12424	A	C	MI.19408	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	88	30	N	H	Aac/Cac	-7.61	0	0	benign	0	neutral	0.54	neutral	3.7	neutral	-2.27	neutral	-1.26	low_impact	1.16	0.86	neutral	0.85	neutral	1.18	11.65	neutral	0.83	0.85	NA	NA	0.35	neutral	0.31	neutral	0.2	neutral	6	0.45	neutral	0.77	deleterious	-6	neutral	0.61	deleterious	2.1	high_impact	0.27	medium_impact	-0.14	medium_impact	0.60	0.8	29.52	15.35	0.33	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12424	12424	A	G	MI.19409	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	88	30	N	D	Aac/Gac	-7.61	0	0	benign	0.05	neutral	0.25	neutral	3.75	neutral	-1.16	neutral	-1.65	low_impact	1.64	0.85	neutral	0.86	neutral	-0.19	1.16	neutral	0.9	0.9	NA	NA	0.22	neutral	0.28	neutral	0.19	neutral	6	0.73	neutral	0.6	deleterious	-6	neutral	0.30	neutral	0.47	medium_impact	-0.03	medium_impact	0.3	medium_impact	0.61	0.8	29.52	15.35	0.47	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5934	5934	A	C	MI.1941	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	31	11	N	H	Aac/Cac	-8.9	0	0	probably_damaging	1	deleterious	0	neutral	-0.99	deleterious	-3	neutral	-0.84	medium_impact	3.25	0.54	damaging	0.35	neutral	2.88	21.80	deleterious	0.39	0.55	0.76	disease	0.81	disease	0.72	disease	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	1.9	medium_impact	0.38	0.9	2.92	7.08	0.35	N	0.52	polymorphism	0.97	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12424	12424	A	T	MI.19410	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	88	30	N	Y	Aac/Tac	-7.61	0	0	benign	0	neutral	1	neutral	3.67	neutral	-0.99	neutral	-2.09	low_impact	1.84	0.9	neutral	0.82	neutral	1.87	15.43	deleterious	0.62	0.65	NA	NA	0.55	disease	0.36	neutral	0.51	disease	0	0	neutral	1	deleterious	-6	neutral	0.66	deleterious	2.1	high_impact	1.89	high_impact	0.48	medium_impact	0.74	0.85	29.52	15.35	0.23	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12425	12425	A	G	MI.19411	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	89	30	N	S	aAc/aGc	-0.27	0	0	benign	0	neutral	0.46	neutral	3.76	neutral	-0.02	neutral	-0.74	low_impact	0.95	0.89	neutral	1	neutral	-1.09	0.01	neutral	0.81	0.85	NA	NA	0.32	neutral	0.42	neutral	0.17	neutral	7	0.54	neutral	0.73	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.19	medium_impact	-0.34	medium_impact	0.47	0.8	29.52	15.35	0.36	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12425	12425	A	C	MI.19412	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	89	30	N	T	aAc/aCc	-0.27	0	0	benign	0	neutral	0.44	neutral	3.74	neutral	-0.71	neutral	-0.57	neutral_impact	0.74	0.86	neutral	0.98	neutral	-0.72	0.07	neutral	0.75	0.8	NA	NA	0.33	neutral	0.23	neutral	0.2	neutral	6	0.55	neutral	0.72	deleterious	-6	neutral	0.25	neutral	2.1	high_impact	0.18	medium_impact	-0.53	medium_impact	0.67	0.85	29.52	15.35	0.41	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12425	12425	A	T	MI.19413	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	89	30	N	I	aAc/aTc	-0.27	0	0	benign	0	neutral	0.43	neutral	3.68	neutral	-2.63	neutral	-2.46	low_impact	1.84	0.86	neutral	0.91	neutral	1.83	15.16	deleterious	0.59	0.65	NA	NA	0.49	neutral	0.45	neutral	0.41	neutral	2	0.56	neutral	0.72	deleterious	-6	neutral	0.59	deleterious	2.1	high_impact	0.17	medium_impact	0.48	medium_impact	0.52	0.8	29.52	15.35	0.37	N	0.14	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12426	12426	C	A	MI.19414	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	90	30	N	K	aaC/aaA	-2.34	0	0	benign	0.05	neutral	0.37	neutral	3.81	neutral	1.54	neutral	-0.24	neutral_impact	0.46	0.88	neutral	0.95	neutral	0.22	4.92	deleterious	0.84	0.85	NA	NA	0.32	neutral	0.22	neutral	0.2	neutral	6	0.6	neutral	0.66	deleterious	-6	neutral	0.34	neutral	0.47	medium_impact	0.11	medium_impact	-0.78	medium_impact	0.64	0.8	29.52	15.35	0.43	N	0.19	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12426	12426	C	G	MI.19415	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	90	30	N	K	aaC/aaG	-2.34	0	0	benign	0.05	neutral	0.37	neutral	3.81	neutral	1.54	neutral	-0.24	neutral_impact	0.46	0.88	neutral	0.95	neutral	-0.18	1.21	neutral	0.84	0.85	NA	NA	0.32	neutral	0.22	neutral	0.2	neutral	6	0.6	neutral	0.66	deleterious	-6	neutral	0.34	neutral	0.47	medium_impact	0.11	medium_impact	-0.78	medium_impact	0.64	0.8	29.52	15.35	0.42	N	0.19	polymorphism	1	0.00	rs386829158	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12427	12427	T	G	MI.19416	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	91	31	S	A	Tca/Gca	-12.66	0	0	benign	0.05	neutral	0.53	neutral	3.8	neutral	-0.83	neutral	-0.99	low_impact	1.58	0.83	neutral	0.88	neutral	-0.17	1.26	neutral	0.45	0.55	NA	NA	0.1	neutral	0.29	neutral	0.23	neutral	5	0.41	neutral	0.74	deleterious	-6	neutral	0.21	neutral	0.47	medium_impact	0.26	medium_impact	0.24	medium_impact	0.56	0.8	29.19	16.74	0.36	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12427	12427	T	C	MI.19417	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	91	31	S	P	Tca/Cca	-12.66	0	0	benign	0	neutral	0.24	neutral	3.71	neutral	-2.06	neutral	-1.44	low_impact	1.3	0.84	neutral	0.81	neutral	2.25	17.81	deleterious	0.31	0.45	NA	NA	0.45	neutral	0.17	neutral	0.2	neutral	6	0.76	neutral	0.62	deleterious	-6	neutral	0.65	deleterious	2.1	high_impact	-0.04	medium_impact	-0.02	medium_impact	0.41	0.8	29.19	16.74	0.48	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12427	12427	T	A	MI.19418	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	91	31	S	T	Tca/Aca	-12.66	0	0	benign	0.01	neutral	0.41	neutral	3.77	neutral	-0.77	neutral	-0.35	low_impact	1.38	0.85	neutral	0.97	neutral	0.30	5.66	deleterious	0.41	0.5	NA	NA	0.11	neutral	0.15	neutral	0.23	neutral	5	0.58	neutral	0.7	deleterious	-6	neutral	0.29	neutral	1.15	medium_impact	0.15	medium_impact	0.06	medium_impact	0.61	0.8	29.19	16.74	0.53	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12428	12428	C	G	MI.19419	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	92	31	S	W	tCa/tGa	-6.24	0	0	possibly_damaging	0.77	neutral	0.19	neutral	3.7	deleterious	-4.69	deleterious	-2.68	low_impact	1.58	0.77	neutral	0.84	neutral	2.67	20.60	deleterious	0.25	0.45	NA	NA	0.16	neutral	0.49	neutral	0.23	neutral	6	0.87	neutral	0.21	neutral	-3	neutral	0.64	deleterious	-1.24	low_impact	-0.12	medium_impact	0.24	medium_impact	0.50	0.8	29.19	16.74	0.42	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5934	5934	A	G	MI.1942	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	31	11	N	D	Aac/Gac	-8.9	0	0	probably_damaging	0.98	neutral	0.06	neutral	-0.95	neutral	1.31	neutral	-0.84	low_impact	0.89	0.52	damaging	0.44	neutral	3.69	23.30	deleterious	0.6	0.65	0.16	neutral	0.78	disease	0.57	disease	0.69	disease	4	0.99	deleterious	0.04	neutral	-2	neutral	0.71	deleterious	-2.35	low_impact	-0.47	medium_impact	-0.28	medium_impact	0.55	0.9	2.92	7.08	0.4	N	0.78	polymorphism	0.98	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12428	12428	C	T	MI.19420	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	92	31	S	L	tCa/tTa	-6.24	0	0	benign	0	neutral	0.69	neutral	3.75	neutral	1.45	neutral	-0.94	neutral_impact	0.61	0.86	neutral	0.98	neutral	0.40	6.62	deleterious	0.37	0.5	NA	NA	0.21	neutral	0.35	neutral	0.16	neutral	7	0.3	neutral	0.85	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	0.42	medium_impact	-0.65	medium_impact	0.70	0.85	29.19	16.74	0.42	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12430	12430	T	G	MI.19421	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	94	32	Y	D	Tac/Gac	-3.71	0	0	probably_damaging	1	neutral	0.24	neutral	3.75	deleterious	-10.19	deleterious	-8.57	medium_impact	2.89	0.71	neutral	0.25	damaging	3.74	23.30	deleterious	0.43	0.55	NA	NA	0.53	disease	0.44	neutral	0.5	disease	0	1	deleterious	0.12	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.04	medium_impact	1.44	medium_impact	0.42	0.8	14.1	12.81	0.32	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12430	12430	T	A	MI.19422	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	94	32	Y	N	Tac/Aac	-3.71	0	0	probably_damaging	1	neutral	0.38	neutral	3.77	deleterious	-9.1	deleterious	-7.84	medium_impact	2.54	0.73	neutral	0.43	neutral	2.78	21.30	deleterious	0.48	0.55	NA	NA	0.42	neutral	0.29	neutral	0.2	neutral	6	1	deleterious	0.19	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.12	medium_impact	1.12	medium_impact	0.25	0.8	14.1	12.81	0.35	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12430	12430	T	C	MI.19423	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	94	32	Y	H	Tac/Cac	-3.71	0	0	probably_damaging	1	neutral	0.54	neutral	3.76	deleterious	-7.81	deleterious	-4.57	medium_impact	2.54	0.73	neutral	0.43	neutral	2.22	17.63	deleterious	0.55	0.6	NA	NA	0.27	neutral	0.28	neutral	0.2	neutral	6	1	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.27	medium_impact	1.12	medium_impact	0.36	0.8	14.1	12.81	0.31	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12431	12431	A	G	MI.19424	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	95	32	Y	C	tAc/tGc	1.1	0	0	probably_damaging	1	neutral	0.17	neutral	3.74	deleterious	-10.48	deleterious	-7.73	medium_impact	2.89	0.65	neutral	0.2	damaging	3.19	22.70	deleterious	0.36	0.5	NA	NA	0.53	disease	0.48	neutral	0.51	disease	0	1	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.15	medium_impact	1.44	medium_impact	0.13	0.8	14.1	12.81	0.33	N	0.92	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12431	12431	A	C	MI.19425	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	95	32	Y	S	tAc/tCc	1.1	0	0	probably_damaging	1	neutral	0.48	neutral	3.8	deleterious	-8.94	deleterious	-7.64	medium_impact	2.54	0.75	neutral	0.51	neutral	2.29	18.07	deleterious	0.27	0.45	NA	NA	0.38	neutral	0.45	neutral	0.15	neutral	7	1	deleterious	0.24	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.21	medium_impact	1.12	medium_impact	0.31	0.8	14.1	12.81	0.37	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12431	12431	A	T	MI.19426	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	95	32	Y	F	tAc/tTc	1.1	0	0	probably_damaging	1	neutral	0.74	neutral	3.8	deleterious	-5.07	neutral	-2.11	medium_impact	2.08	0.81	neutral	0.93	neutral	1.05	10.93	neutral	0.49	0.55	NA	NA	0.17	neutral	0.21	neutral	0.22	neutral	6	0.99	deleterious	0.37	neutral	1	deleterious	0.70	deleterious	-3.6	low_impact	0.48	medium_impact	0.7	medium_impact	0.24	0.8	14.1	12.81	0.3	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12433	12433	C	G	MI.19427	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	97	33	P	A	Ccc/Gcc	-5.55	0	0	probably_damaging	1	neutral	0.56	neutral	3.83	deleterious	-4.89	deleterious	-6.24	low_impact	1.61	0.8	neutral	0.51	neutral	1.52	13.41	neutral	0.33	0.5	0.67	disease	0.19	neutral	0.3	neutral	0.45	neutral	1	1	deleterious	0.28	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.29	medium_impact	0.27	medium_impact	0.77	0.85	11.11	14.64	0.25	N	0.71	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12433	12433	C	A	MI.19428	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	97	33	P	T	Ccc/Acc	-5.55	0	0	probably_damaging	1	neutral	0.44	neutral	3.8	deleterious	-6.05	deleterious	-6.2	medium_impact	2.53	0.75	neutral	0.34	neutral	2.36	18.55	deleterious	0.39	0.5	0.73	disease	0.41	neutral	0.17	neutral	0.66	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.18	medium_impact	1.11	medium_impact	0.66	0.8	11.11	14.64	0.36	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12433	12433	C	T	MI.19429	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	97	33	P	S	Ccc/Tcc	-5.55	0	0	probably_damaging	1	neutral	0.46	neutral	3.82	deleterious	-5.36	deleterious	-6.05	medium_impact	2.38	0.8	neutral	0.8	neutral	2.49	19.43	deleterious	0.42	0.55	0.67	disease	0.45	neutral	0.3	neutral	0.63	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.19	medium_impact	0.97	medium_impact	0.35	0.8	11.11	14.64	0.34	N	0.75	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5934	5934	A	T	MI.1943	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	31	11	N	Y	Aac/Tac	-8.9	0	0	probably_damaging	1	deleterious	0	neutral	-0.99	deleterious	-5.03	neutral	-1.35	high_impact	4.15	0.55	damaging	0.37	neutral	3.54	23.10	deleterious	0.3	0.55	0.86	disease	0.88	disease	0.72	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.73	high_impact	0.37	0.9	2.92	7.08	0.34	N	0.83	polymorphism	0.88	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12434	12434	C	G	MI.19430	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	98	33	P	R	cCc/cGc	-0.5	0	0	probably_damaging	1	neutral	0.38	neutral	3.79	deleterious	-6.82	deleterious	-7.27	medium_impact	2.73	0.7	neutral	0.21	damaging	3.39	23.00	deleterious	0.38	0.5	0.64	disease	0.57	disease	0.46	neutral	0.53	disease	1	1	deleterious	0.19	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.12	medium_impact	1.29	medium_impact	0.65	0.8	11.11	14.64	0.28	N	0.69	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12434	12434	C	A	MI.19431	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	98	33	P	H	cCc/cAc	-0.5	0	0	probably_damaging	1	neutral	0.55	neutral	3.74	deleterious	-8.01	deleterious	-7.36	medium_impact	2.73	0.76	neutral	0.31	neutral	3.82	23.40	deleterious	0.37	0.5	0.82	disease	0.46	neutral	0.29	neutral	0.66	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.28	medium_impact	1.29	medium_impact	0.55	0.8	11.11	14.64	0.29	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12434	12434	C	T	MI.19432	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	98	33	P	L	cCc/cTc	-0.5	0	0	probably_damaging	1	neutral	0.68	neutral	3.78	deleterious	-7.24	deleterious	-8.05	medium_impact	2.19	0.83	neutral	0.91	neutral	2.88	21.80	deleterious	0.36	0.5	0.81	disease	0.36	neutral	0.37	neutral	0.67	disease	3	1	deleterious	0.34	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.41	medium_impact	0.8	medium_impact	0.80	0.85	11.11	14.64	0.34	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12436	12436	C	G	MI.19433	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	100	34	H	D	Cat/Gat	-9.22	0	0	benign	0.01	neutral	0.23	neutral	3.79	neutral	0.78	neutral	-2.04	low_impact	1.09	0.82	neutral	0.83	neutral	1.63	14.04	neutral	0.32	0.5	0.37	neutral	0.36	neutral	0.53	disease	0.48	neutral	0	0.77	neutral	0.61	deleterious	-6	neutral	0.68	deleterious	1.15	medium_impact	-0.06	medium_impact	-0.21	medium_impact	0.46	0.8	29.52	18.37	0.34	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12436	12436	C	A	MI.19434	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	100	34	H	N	Cat/Aat	-9.22	0	0	benign	0	neutral	0.33	neutral	3.81	neutral	1.63	neutral	-0.4	neutral_impact	0.78	0.9	neutral	0.93	neutral	1.71	14.48	neutral	0.62	0.65	0.4	neutral	0.22	neutral	0.28	neutral	0.4	neutral	2	0.67	neutral	0.67	deleterious	-6	neutral	0.65	deleterious	2.1	high_impact	0.06	medium_impact	-0.49	medium_impact	0.55	0.8	29.52	18.37	0.44	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12436	12436	C	T	MI.19435	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	100	34	H	Y	Cat/Tat	-9.22	0	0	benign	0	neutral	1	neutral	3.76	neutral	2.11	neutral	-1.3	neutral_impact	0.6	0.87	neutral	0.93	neutral	1.93	15.80	deleterious	0.64	0.7	0.5	disease	0.28	neutral	0.19	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.69	deleterious	2.1	high_impact	1.89	high_impact	-0.66	medium_impact	0.38	0.8	29.52	18.37	0.38	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12437	12437	A	C	MI.19436	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	101	34	H	P	cAt/cCt	-8.99	0	0	possibly_damaging	0.5	neutral	0.22	neutral	3.75	neutral	-0.22	deleterious	-2.94	medium_impact	2.19	0.84	neutral	0.8	neutral	1.56	13.65	neutral	0.25	0.45	0.66	disease	0.6	disease	0.48	neutral	0.5	neutral	0	0.76	neutral	0.36	neutral	0	NA	0.81	deleterious	-0.75	medium_impact	-0.07	medium_impact	0.8	medium_impact	0.35	0.8	29.52	18.37	0.33	N	0.64	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12437	12437	A	T	MI.19437	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	101	34	H	L	cAt/cTt	-8.99	0	0	benign	0.18	neutral	0.66	neutral	3.81	neutral	2.15	deleterious	-3.06	low_impact	1.15	0.82	neutral	0.98	neutral	1.93	15.79	deleterious	0.38	0.5	0.28	neutral	0.27	neutral	0.41	neutral	0.42	neutral	2	0.22	neutral	0.74	deleterious	-6	neutral	0.64	deleterious	-0.12	medium_impact	0.39	medium_impact	-0.15	medium_impact	0.28	0.8	29.52	18.37	0.38	N	0.09	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12437	12437	A	G	MI.19438	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	101	34	H	R	cAt/cGt	-8.99	0	0	benign	0.24	neutral	0.37	neutral	3.83	neutral	0.71	neutral	-1.72	medium_impact	2.19	0.85	neutral	0.65	neutral	0.84	9.71	deleterious	0.73	0.75	0.54	disease	0.27	neutral	0.4	neutral	0.42	neutral	2	0.55	neutral	0.57	deleterious	-3	neutral	0.71	deleterious	-0.27	medium_impact	0.11	medium_impact	0.8	medium_impact	0.46	0.8	29.52	18.37	0.34	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12438	12438	T	G	MI.19439	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	102	34	H	Q	caT/caG	-7.16	0	0	benign	0.3	neutral	0.32	neutral	3.81	neutral	2.37	neutral	-0.91	low_impact	0.84	0.82	neutral	0.98	neutral	1.25	12.02	neutral	0.67	0.7	0.54	disease	0.2	neutral	0.44	neutral	0.38	neutral	2	0.61	neutral	0.51	deleterious	-6	neutral	0.69	deleterious	-0.4	medium_impact	0.05	medium_impact	-0.44	medium_impact	0.59	0.8	29.52	18.37	0.38	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5935	5935	A	T	MI.1944	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	32	11	N	I	aAc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	-0.99	deleterious	-4.94	neutral	-1.52	high_impact	3.6	0.54	damaging	0.5	neutral	3.63	23.20	deleterious	0.27	0.55	0.85	disease	0.9	disease	0.68	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.29	0.9	2.92	7.08	0.53	P	0.86	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12438	12438	T	A	MI.19440	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	102	34	H	Q	caT/caA	-7.16	0	0	benign	0.3	neutral	0.32	neutral	3.81	neutral	2.37	neutral	-0.91	low_impact	0.84	0.82	neutral	0.98	neutral	1.34	12.46	neutral	0.67	0.7	0.54	disease	0.2	neutral	0.44	neutral	0.38	neutral	2	0.61	neutral	0.51	deleterious	-6	neutral	0.69	deleterious	-0.4	medium_impact	0.05	medium_impact	-0.44	medium_impact	0.59	0.8	29.52	18.37	0.39	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12439	12439	T	C	MI.19441	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	103	35	Y	H	Tat/Cat	-8.99	0	0	benign	0.07	neutral	0.57	neutral	3.76	deleterious	-4.01	deleterious	-2.57	low_impact	1.7	0.79	neutral	0.92	neutral	1.32	12.37	neutral	0.52	0.6	0.59	disease	0.12	neutral	0.27	neutral	0.28	neutral	4	0.36	neutral	0.75	deleterious	-6	neutral	0.72	deleterious	0.32	medium_impact	0.3	medium_impact	0.35	medium_impact	0.54	0.8	6.97	9.53	0.34	N	0.98	polymorphism	1	0.06	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12439	12439	T	A	MI.19442	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	103	35	Y	N	Tat/Aat	-8.99	0	0	possibly_damaging	0.81	neutral	0.48	neutral	3.77	deleterious	-8.02	deleterious	-6.79	medium_impact	2.25	0.78	neutral	0.84	neutral	3.94	23.50	deleterious	0.4	0.5	0.66	disease	0.46	neutral	0.38	neutral	0.63	disease	3	0.79	neutral	0.34	neutral	0	NA	0.76	deleterious	-1.34	low_impact	0.21	medium_impact	0.85	medium_impact	0.36	0.8	6.97	9.53	0.35	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12439	12439	T	G	MI.19443	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	103	35	Y	D	Tat/Gat	-8.99	0	0	possibly_damaging	0.89	neutral	0.43	neutral	3.76	deleterious	-8.88	deleterious	-7.92	medium_impact	2.4	0.77	neutral	0.65	neutral	3.72	23.30	deleterious	0.32	0.5	0.76	disease	0.59	disease	0.68	disease	0.68	disease	4	0.89	neutral	0.27	neutral	0	NA	0.80	deleterious	-1.61	low_impact	0.17	medium_impact	0.99	medium_impact	0.51	0.8	6.97	9.53	0.3	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12440	12440	A	C	MI.19444	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	104	35	Y	S	tAt/tCt	-0.5	0	0	possibly_damaging	0.85	neutral	0.66	neutral	3.81	deleterious	-7.82	deleterious	-7.09	medium_impact	2.13	0.8	neutral	0.84	neutral	3.53	23.10	deleterious	0.34	0.5	0.49	neutral	0.43	neutral	0.55	disease	0.46	neutral	1	0.83	neutral	0.41	neutral	0	NA	0.75	deleterious	-1.46	low_impact	0.39	medium_impact	0.74	medium_impact	0.46	0.8	6.97	9.53	0.32	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12440	12440	A	G	MI.19445	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	104	35	Y	C	tAt/tGt	-0.5	0	0	probably_damaging	0.96	neutral	0.2	neutral	3.73	deleterious	-9.53	deleterious	-7.39	medium_impact	2.94	0.7	neutral	0.53	neutral	3.34	22.90	deleterious	0.41	0.5	0.69	disease	0.61	disease	0.4	neutral	0.51	disease	0	0.97	neutral	0.12	neutral	1	deleterious	0.77	deleterious	-2.06	low_impact	-0.1	medium_impact	1.48	medium_impact	0.20	0.8	6.97	9.53	0.38	N	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12440	12440	A	T	MI.19446	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	104	35	Y	F	tAt/tTt	-0.5	0	0	possibly_damaging	0.74	neutral	0.71	neutral	3.79	deleterious	-4.59	deleterious	-3.35	medium_impact	2.4	0.77	neutral	0.81	neutral	3.12	22.60	deleterious	0.5	0.6	0.49	neutral	0.35	neutral	0.27	neutral	0.43	neutral	2	0.69	neutral	0.49	deleterious	0	NA	0.71	deleterious	-1.18	low_impact	0.45	medium_impact	0.99	medium_impact	0.40	0.8	6.97	9.53	0.29	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12442	12442	G	C	MI.19447	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	106	36	V	L	Gta/Cta	-11.05	0	0	benign	0.31	neutral	0.86	neutral	3.74	deleterious	-5.18	neutral	-2.45	medium_impact	2.53	0.7	neutral	0.62	neutral	1.54	13.54	neutral	0.5	0.6	0.25	neutral	0.67	disease	0.54	disease	0.58	disease	2	0.2	neutral	0.78	deleterious	-3	neutral	0.40	neutral	-0.42	medium_impact	0.67	medium_impact	1.11	medium_impact	0.75	0.85	23.71	17.6	0.3	N	0.55	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12442	12442	G	A	MI.19448	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	106	36	V	M	Gta/Ata	-11.05	0	0	probably_damaging	0.94	neutral	0.31	neutral	3.61	deleterious	-7.17	neutral	-2.46	medium_impact	2.73	0.78	neutral	0.7	neutral	3.39	23.00	deleterious	0.44	0.55	0.41	neutral	0.58	disease	0.25	neutral	0.48	neutral	0	0.95	neutral	0.19	neutral	1	deleterious	0.66	deleterious	-1.88	low_impact	0.04	medium_impact	1.29	medium_impact	0.79	0.85	23.71	17.6	0.37	N	0.60	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12442	12442	G	T	MI.19449	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	106	36	V	L	Gta/Tta	-11.05	0	0	benign	0.31	neutral	0.86	neutral	3.74	deleterious	-5.18	neutral	-2.45	medium_impact	2.53	0.7	neutral	0.62	neutral	1.65	14.12	neutral	0.5	0.6	0.25	neutral	0.67	disease	0.54	disease	0.58	disease	2	0.2	neutral	0.78	deleterious	-3	neutral	0.40	neutral	-0.42	medium_impact	0.67	medium_impact	1.11	medium_impact	0.75	0.85	23.71	17.6	0.3	N	0.55	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5935	5935	A	G	MI.1945	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	32	11	N	S	aAc/aGc	8.69	1	0	probably_damaging	0.94	neutral	0.05	neutral	-0.96	neutral	-2.18	neutral	-0.84	medium_impact	2.56	0.47	damaging	0.49	neutral	2.78	21.30	deleterious	0.51	0.6	0.49	neutral	0.74	disease	0.6	disease	0.56	disease	1	0.99	deleterious	0.06	neutral	1	deleterious	0.79	deleterious	-1.88	low_impact	-0.52	medium_impact	1.27	medium_impact	0.28	0.9	2.92	7.08	0.7	P	0.17	disease_causing	1	0.03	.	.	.	.	.	.	.	.	0.15	A5935G	Prostate Cancer	+	-	Reported	1	.	P	P	damaging
chrM	12443	12443	T	A	MI.19450	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	107	36	V	E	gTa/gAa	0.41	0	0	possibly_damaging	0.74	neutral	0.29	neutral	3.58	deleterious	-9.06	deleterious	-5.2	medium_impact	3.08	0.71	neutral	0.46	neutral	2.71	20.90	deleterious	0.13	0.4	0.71	disease	0.86	disease	0.71	disease	0.78	disease	6	0.8	neutral	0.28	neutral	0	NA	0.69	deleterious	-1.18	low_impact	0.02	medium_impact	1.61	medium_impact	0.62	0.8	23.71	17.6	0.32	N	0.95	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12443	12443	T	G	MI.19451	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	107	36	V	G	gTa/gGa	0.41	0	0	possibly_damaging	0.56	neutral	0.32	neutral	3.59	deleterious	-8.82	deleterious	-6.17	medium_impact	3.08	0.67	neutral	0.6	neutral	1.74	14.65	neutral	0.17	0.45	0.69	disease	0.79	disease	0.62	disease	0.7	disease	4	0.68	neutral	0.38	neutral	0	NA	0.56	deleterious	-0.85	medium_impact	0.05	medium_impact	1.61	medium_impact	0.62	0.8	23.71	17.6	0.32	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12443	12443	T	C	MI.19452	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	107	36	V	A	gTa/gCa	0.41	0	0	benign	0.02	neutral	0.55	neutral	3.69	deleterious	-6.63	deleterious	-3.36	medium_impact	3.08	0.79	neutral	0.8	neutral	0.31	5.80	deleterious	0.38	0.5	0.43	neutral	0.39	neutral	0.29	neutral	0.46	neutral	1	0.42	neutral	0.77	deleterious	-3	neutral	0.20	neutral	0.86	medium_impact	0.28	medium_impact	1.61	medium_impact	0.56	0.8	23.71	17.6	0.39	N	0.37	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12445	12445	A	G	MI.19453	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	109	37	K	E	Aaa/Gaa	-5.78	0	0	probably_damaging	1	neutral	0.34	neutral	3.69	deleterious	-6.4	deleterious	-3.51	medium_impact	2.52	0.72	neutral	0.3	neutral	3.79	23.40	deleterious	0.35	0.5	0.58	disease	0.86	disease	0.75	disease	0.79	disease	6	1	deleterious	0.17	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.07	medium_impact	1.1	medium_impact	0.65	0.8	11.28	13.79	0.28	N	0.75	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12445	12445	A	C	MI.19454	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	109	37	K	Q	Aaa/Caa	-5.78	0	0	probably_damaging	1	neutral	0.31	neutral	3.66	deleterious	-6.26	deleterious	-3.51	medium_impact	2.87	0.73	neutral	0.21	damaging	3.21	22.70	deleterious	0.41	0.5	0.61	disease	0.79	disease	0.52	disease	0.66	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.04	medium_impact	1.42	medium_impact	0.66	0.8	11.28	13.79	0.28	N	0.71	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12446	12446	A	C	MI.19455	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	110	37	K	T	aAa/aCa	1.79	0	0	probably_damaging	1	neutral	0.58	neutral	3.7	deleterious	-6	deleterious	-4.75	medium_impact	2.06	0.8	neutral	0.85	neutral	2.24	17.80	deleterious	0.32	0.5	0.37	neutral	0.62	disease	0.35	neutral	0.44	neutral	1	1	deleterious	0.29	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.31	medium_impact	0.68	medium_impact	0.44	0.8	11.28	13.79	0.29	N	0.46	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12446	12446	A	T	MI.19456	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	110	37	K	M	aAa/aTa	1.79	0	0	probably_damaging	1	neutral	0.27	neutral	3.63	deleterious	-8.64	deleterious	-5.17	medium_impact	2.66	0.71	neutral	0.19	damaging	3.61	23.20	deleterious	0.27	0.45	0.48	neutral	0.77	disease	0.36	neutral	0.58	disease	2	1	deleterious	0.14	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.01	medium_impact	1.23	medium_impact	0.41	0.8	11.28	13.79	0.33	N	0.82	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12447	12447	A	T	MI.19457	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	111	37	K	N	aaA/aaT	1.1	0	0	probably_damaging	1	neutral	0.4	neutral	3.65	deleterious	-6.89	deleterious	-4.23	medium_impact	3.21	0.69	neutral	0.22	damaging	3.67	23.30	deleterious	0.52	0.6	0.63	disease	0.81	disease	0.66	disease	0.71	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.14	medium_impact	1.73	medium_impact	0.65	0.8	11.28	13.79	0.28	N	0.64	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12447	12447	A	C	MI.19458	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	111	37	K	N	aaA/aaC	1.1	0	0	probably_damaging	1	neutral	0.4	neutral	3.65	deleterious	-6.89	deleterious	-4.23	medium_impact	3.21	0.69	neutral	0.22	damaging	3.60	23.20	deleterious	0.52	0.6	0.63	disease	0.81	disease	0.66	disease	0.71	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.14	medium_impact	1.73	medium_impact	0.65	0.8	11.28	13.79	0.28	N	0.64	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12448	12448	T	A	MI.19459	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	112	38	S	T	Tcc/Acc	-0.27	0	0	benign	0	neutral	0.5	neutral	3.81	neutral	3.11	neutral	1.39	neutral_impact	-1.3	0.87	neutral	0.99	neutral	-0.88	0.03	neutral	0.39	0.5	0.24	neutral	0.04	neutral	0.17	neutral	0.22	neutral	6	0.5	neutral	0.75	deleterious	-6	neutral	0.09	neutral	2.1	high_impact	0.23	medium_impact	-2.39	low_impact	0.86	0.9	21.56	14.65	0.48	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5935	5935	A	C	MI.1946	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	32	11	N	T	aAc/aCc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	-0.97	deleterious	-3.19	neutral	-1.01	high_impact	3.6	0.45	damaging	0.45	neutral	3.12	22.50	deleterious	0.34	0.55	0.66	disease	0.8	disease	0.68	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	2.23	high_impact	0.53	0.9	2.92	7.08	0.62	P	0.49	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12448	12448	T	C	MI.19460	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	112	38	S	P	Tcc/Ccc	-0.27	0	0	benign	0.19	neutral	0.24	neutral	3.68	neutral	-2.76	neutral	-2.46	low_impact	1.32	0.59	damaging	0.55	neutral	2.05	16.53	deleterious	0.22	0.45	0.65	disease	0.71	disease	0.67	disease	0.74	disease	5	0.72	neutral	0.53	deleterious	-6	neutral	0.54	deleterious	-0.15	medium_impact	-0.04	medium_impact	0	medium_impact	0.81	0.85	21.56	14.65	0.29	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12448	12448	T	G	MI.19461	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	112	38	S	A	Tcc/Gcc	-0.27	0	0	benign	0.02	neutral	0.56	neutral	3.77	neutral	-0.71	neutral	-1.31	low_impact	1.66	0.78	neutral	0.84	neutral	1.60	13.85	neutral	0.53	0.6	0.37	neutral	0.18	neutral	0.49	neutral	0.29	neutral	4	0.41	neutral	0.77	deleterious	-6	neutral	0.16	neutral	0.86	medium_impact	0.29	medium_impact	0.31	medium_impact	0.75	0.85	21.56	14.65	0.34	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12449	12449	C	G	MI.19462	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	113	38	S	C	tCc/tGc	-0.73	0	0	possibly_damaging	0.57	neutral	0.19	neutral	3.66	deleterious	-3.57	neutral	-2.35	low_impact	1.66	0.68	neutral	0.5	neutral	3.04	22.40	deleterious	0.33	0.5	0.77	disease	0.51	disease	0.53	disease	0.64	disease	3	0.81	neutral	0.31	neutral	-3	neutral	0.65	deleterious	-0.86	medium_impact	-0.12	medium_impact	0.31	medium_impact	0.78	0.85	21.56	14.65	0.34	N	0.64	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12449	12449	C	T	MI.19463	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	113	38	S	F	tCc/tTc	-0.73	0	0	benign	0.08	neutral	0.74	neutral	3.68	neutral	-2.92	deleterious	-2.88	low_impact	1.32	0.69	neutral	0.55	neutral	2.09	16.79	deleterious	0.29	0.45	0.41	neutral	0.63	disease	0.57	disease	0.73	disease	5	0.16	neutral	0.83	deleterious	-6	neutral	0.37	neutral	0.26	medium_impact	0.48	medium_impact	0	medium_impact	0.45	0.8	21.56	14.65	0.24	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12449	12449	C	A	MI.19464	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	113	38	S	Y	tCc/tAc	-0.73	0	0	benign	0.29	neutral	1	neutral	3.67	deleterious	-3.08	deleterious	-2.9	low_impact	1.66	0.74	neutral	0.74	neutral	2.32	18.29	deleterious	0.26	0.45	0.63	disease	0.54	disease	0.5	neutral	0.5	neutral	0	0.29	neutral	0.86	deleterious	-6	neutral	0.58	deleterious	-0.38	medium_impact	1.89	high_impact	0.31	medium_impact	0.75	0.85	21.56	14.65	0.22	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12451	12451	A	G	MI.19465	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	115	39	I	V	Att/Gtt	-7.84	0	0	benign	0	neutral	0.53	neutral	3.76	neutral	0.52	neutral	0.12	low_impact	1.7	0.81	neutral	0.85	neutral	0.86	9.84	deleterious	0.6	0.65	0.38	neutral	0.21	neutral	0.49	neutral	0.39	neutral	2	0.47	neutral	0.77	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.26	medium_impact	0.35	medium_impact	0.64	0.8	19.9	12.29	0.33	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12451	12451	A	C	MI.19466	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	115	39	I	L	Att/Ctt	-7.84	0	0	benign	0.02	neutral	0.7	neutral	3.76	neutral	0.06	neutral	-0.09	low_impact	1.7	0.79	neutral	0.78	neutral	1.63	14.02	neutral	0.33	0.5	0.22	neutral	0.31	neutral	0.35	neutral	0.45	neutral	1	0.26	neutral	0.84	deleterious	-6	neutral	0.14	neutral	0.86	medium_impact	0.44	medium_impact	0.35	medium_impact	0.74	0.85	19.9	12.29	0.32	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12451	12451	A	T	MI.19467	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	115	39	I	F	Att/Ttt	-7.84	0	0	benign	0.33	neutral	0.73	neutral	3.65	neutral	-1.34	neutral	-1.25	low_impact	1.7	0.67	neutral	0.67	neutral	2.07	16.68	deleterious	0.36	0.5	0.59	disease	0.56	disease	0.39	neutral	0.51	disease	0	0.24	neutral	0.7	deleterious	-6	neutral	0.44	deleterious	-0.45	medium_impact	0.47	medium_impact	0.35	medium_impact	0.75	0.85	19.9	12.29	0.22	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12452	12452	T	G	MI.19468	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	116	39	I	S	aTt/aGt	-0.96	0	0	benign	0.08	neutral	0.47	neutral	3.64	neutral	0.25	neutral	1.09	neutral_impact	0.66	0.82	neutral	0.95	neutral	0.57	7.96	deleterious	0.22	0.45	0.52	disease	0.38	neutral	0.27	neutral	0.39	neutral	2	0.47	neutral	0.7	deleterious	-6	neutral	0.26	neutral	0.26	medium_impact	0.2	medium_impact	-0.6	medium_impact	0.61	0.8	19.9	12.29	0.33	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12452	12452	T	C	MI.19469	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	116	39	I	T	aTt/aCt	-0.96	0	0	benign	0	neutral	0.47	neutral	3.67	neutral	3.03	neutral	1.16	neutral_impact	-0.88	0.89	neutral	0.99	neutral	-0.44	0.31	neutral	0.34	0.5	0.38	neutral	0.15	neutral	0.25	neutral	0.3	neutral	4	0.53	neutral	0.74	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.2	medium_impact	-2.01	low_impact	0.71	0.85	19.9	12.29	0.36	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5936	5936	C	A	MI.1947	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	33	11	N	K	aaC/aaA	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-0.97	neutral	-2.52	neutral	-1.01	high_impact	3.6	0.47	damaging	0.43	neutral	4.30	24.00	deleterious	0.51	0.6	0.57	disease	0.84	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.55	0.9	2.92	7.08	0.6	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12452	12452	T	A	MI.19470	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	116	39	I	N	aTt/aAt	-0.96	0	0	benign	0.18	neutral	0.34	neutral	3.59	neutral	-1.45	neutral	-0.8	low_impact	1.7	0.69	neutral	0.76	neutral	2.44	19.09	deleterious	0.17	0.45	0.75	disease	0.61	disease	0.53	disease	0.61	disease	2	0.6	neutral	0.58	deleterious	-6	neutral	0.56	deleterious	-0.12	medium_impact	0.07	medium_impact	0.35	medium_impact	0.62	0.8	19.9	12.29	0.37	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12453	12453	T	G	MI.19471	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	117	39	I	M	atT/atG	-0.27	0	0	possibly_damaging	0.52	neutral	0.24	neutral	3.64	neutral	-0.4	neutral	0.06	low_impact	1.15	0.81	neutral	0.95	neutral	1.46	13.12	neutral	0.41	0.5	0.59	disease	0.2	neutral	0.22	neutral	0.46	neutral	1	0.74	neutral	0.36	neutral	-3	neutral	0.54	deleterious	-0.78	medium_impact	-0.04	medium_impact	-0.15	medium_impact	0.82	0.85	19.9	12.29	0.47	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12453	12453	T	A	MI.19472	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	117	39	I	M	atT/atA	-0.27	0	0	possibly_damaging	0.52	neutral	0.24	neutral	3.64	neutral	-0.4	neutral	0.06	low_impact	1.15	0.81	neutral	0.95	neutral	1.81	15.02	deleterious	0.41	0.5	0.59	disease	0.2	neutral	0.22	neutral	0.46	neutral	1	0.74	neutral	0.36	neutral	-3	neutral	0.54	deleterious	-0.78	medium_impact	-0.04	medium_impact	-0.15	medium_impact	0.82	0.85	19.9	12.29	0.47	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12454	12454	G	T	MI.19473	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	118	40	V	F	Gtc/Ttc	-7.38	0	0	benign	0.14	neutral	0.71	neutral	3.57	deleterious	-4.83	deleterious	-3.35	medium_impact	2.12	0.63	neutral	0.57	neutral	1.80	14.97	neutral	0.21	0.45	0.22	neutral	0.91	disease	0.66	disease	0.77	disease	5	0.17	neutral	0.79	deleterious	-3	neutral	0.42	neutral	0	medium_impact	0.45	medium_impact	0.73	medium_impact	0.74	0.85	12.77	12.59	0.3	N	0.41	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12454	12454	G	C	MI.19474	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	118	40	V	L	Gtc/Ctc	-7.38	0	0	benign	0.01	neutral	0.68	neutral	3.7	neutral	-2.73	neutral	-1.56	low_impact	1.57	0.71	neutral	0.66	neutral	1.42	12.90	neutral	0.44	0.55	0.31	neutral	0.71	disease	0.48	neutral	0.53	disease	1	0.29	neutral	0.84	deleterious	-6	neutral	0.21	neutral	1.15	medium_impact	0.41	medium_impact	0.23	medium_impact	0.76	0.85	12.77	12.59	0.29	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12454	12454	G	A	MI.19475	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	118	40	V	I	Gtc/Atc	-7.38	0	0	benign	0	neutral	0.42	neutral	3.71	neutral	0.57	neutral	0.05	neutral_impact	-0.57	0.83	neutral	0.97	neutral	-0.56	0.16	neutral	0.46	0.55	0.25	neutral	0.25	neutral	0.31	neutral	0.4	neutral	2	0.58	neutral	0.71	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.16	medium_impact	-1.72	low_impact	0.87	0.9	12.77	12.59	0.35	N	0.02	polymorphism	1	0.01	rs200656196	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12455	12455	T	C	MI.19476	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	119	40	V	A	gTc/gCc	-1.19	0	0	benign	0.05	neutral	0.56	neutral	3.63	deleterious	-3.94	deleterious	-3.17	medium_impact	2.12	0.64	neutral	0.73	neutral	1.46	13.12	neutral	0.34	0.5	0.42	neutral	0.58	disease	0.61	disease	0.65	disease	3	0.38	neutral	0.76	deleterious	-3	neutral	0.33	neutral	0.47	medium_impact	0.29	medium_impact	0.73	medium_impact	0.80	0.85	12.77	12.59	0.32	N	0.34	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12455	12455	T	A	MI.19477	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	119	40	V	D	gTc/gAc	-1.19	0	0	benign	0.23	neutral	0.25	neutral	3.52	deleterious	-6.89	deleterious	-5.19	medium_impact	2.12	0.61	neutral	0.51	neutral	2.60	20.20	deleterious	0.08	0.35	0.81	disease	0.9	disease	0.75	disease	0.85	disease	7	0.7	neutral	0.51	deleterious	-3	neutral	0.73	deleterious	-0.25	medium_impact	-0.03	medium_impact	0.73	medium_impact	0.80	0.85	12.77	12.59	0.29	N	0.68	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12455	12455	T	G	MI.19478	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	119	40	V	G	gTc/gGc	-1.19	0	0	benign	0.15	neutral	0.36	neutral	3.54	deleterious	-6.11	deleterious	-5.88	medium_impact	2.12	0.61	neutral	0.61	neutral	1.90	15.58	deleterious	0.15	0.4	0.59	disease	0.83	disease	0.68	disease	0.74	disease	5	0.58	neutral	0.61	deleterious	-3	neutral	0.56	deleterious	-0.03	medium_impact	0.1	medium_impact	0.73	medium_impact	0.62	0.8	12.77	12.59	0.28	N	0.61	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12457	12457	G	T	MI.19479	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	121	41	A	S	Gca/Tca	-8.3	0	0	benign	0.29	neutral	0.58	neutral	3.74	neutral	2.74	neutral	0.95	neutral_impact	-0.36	0.82	neutral	0.98	neutral	1.00	10.64	neutral	0.41	0.5	0.27	neutral	0.28	neutral	0.17	neutral	0.44	neutral	1	0.32	neutral	0.65	deleterious	-6	neutral	0.70	deleterious	-0.38	medium_impact	0.31	medium_impact	-1.53	low_impact	0.80	0.85	34.33	23.28	0.41	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5936	5936	C	G	MI.1948	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	33	11	N	K	aaC/aaG	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-0.97	neutral	-2.52	neutral	-1.01	high_impact	3.6	0.47	damaging	0.43	neutral	3.86	23.50	deleterious	0.51	0.6	0.57	disease	0.84	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.55	0.9	2.92	7.08	0.59	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12457	12457	G	C	MI.19480	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	121	41	A	P	Gca/Cca	-8.3	0	0	possibly_damaging	0.7	neutral	0.26	neutral	3.65	neutral	-2.6	neutral	-1.79	low_impact	1.84	0.72	neutral	0.48	neutral	3.53	23.10	deleterious	0.15	0.45	0.74	disease	0.82	disease	0.59	disease	0.78	disease	6	0.8	neutral	0.28	neutral	-3	neutral	0.88	deleterious	-1.1	low_impact	-0.02	medium_impact	0.48	medium_impact	0.79	0.85	34.33	23.28	0.27	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12457	12457	G	A	MI.19481	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	121	41	A	T	Gca/Aca	-8.3	0	0	benign	0.4	neutral	0.52	neutral	3.72	neutral	-0.95	neutral	-0.3	low_impact	1.29	0.83	neutral	0.91	neutral	2.76	21.10	deleterious	0.48	0.55	0.41	neutral	0.38	neutral	0.34	neutral	0.46	neutral	1	0.42	neutral	0.56	deleterious	-6	neutral	0.72	deleterious	-0.58	medium_impact	0.25	medium_impact	-0.02	medium_impact	0.68	0.85	34.33	23.28	0.32	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	COSM1155520	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12458	12458	C	G	MI.19482	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	122	41	A	G	gCa/gGa	-0.04	0	0	possibly_damaging	0.48	neutral	0.41	neutral	3.68	neutral	-2.01	neutral	-1.7	low_impact	1.84	0.76	neutral	0.72	neutral	2.63	20.40	deleterious	0.27	0.45	0.67	disease	0.55	disease	0.41	neutral	0.53	disease	1	0.56	neutral	0.47	neutral	-3	neutral	0.77	deleterious	-0.71	medium_impact	0.15	medium_impact	0.48	medium_impact	0.71	0.85	34.33	23.28	0.3	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12458	12458	C	A	MI.19483	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	122	41	A	E	gCa/gAa	-0.04	0	0	possibly_damaging	0.61	neutral	0.49	neutral	3.7	neutral	-1.09	neutral	-0.85	low_impact	1.84	0.74	neutral	0.63	neutral	3.10	22.50	deleterious	0.21	0.45	0.56	disease	0.77	disease	0.6	disease	0.76	disease	5	0.59	neutral	0.44	neutral	-3	neutral	0.82	deleterious	-0.93	medium_impact	0.22	medium_impact	0.48	medium_impact	0.68	0.85	34.33	23.28	0.27	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12458	12458	C	T	MI.19484	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	122	41	A	V	gCa/gTa	-0.04	0	0	benign	0.07	neutral	0.58	neutral	3.73	neutral	-0.61	neutral	-1.34	low_impact	1.84	0.85	neutral	0.83	neutral	3.16	22.60	deleterious	0.36	0.5	0.4	neutral	0.61	disease	0.46	neutral	0.53	disease	1	0.35	neutral	0.76	deleterious	-6	neutral	0.73	deleterious	0.32	medium_impact	0.31	medium_impact	0.48	medium_impact	0.81	0.85	34.33	23.28	0.28	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12460	12460	T	G	MI.19485	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	124	42	S	A	Tcc/Gcc	-0.96	0	0	benign	0.02	neutral	0.57	neutral	3.83	neutral	-0.35	neutral	0.28	low_impact	1.04	0.8	neutral	0.84	neutral	1.93	15.78	deleterious	0.48	0.55	0.38	neutral	0.11	neutral	0.35	neutral	0.34	neutral	3	0.4	neutral	0.78	deleterious	-6	neutral	0.22	neutral	0.86	medium_impact	0.3	medium_impact	-0.25	medium_impact	0.75	0.85	27.36	14.7	0.35	N	0.19	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12460	12460	T	C	MI.19486	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	124	42	S	P	Tcc/Ccc	-0.96	0	0	benign	0.19	neutral	0.21	neutral	3.71	neutral	-2.41	neutral	-1.33	low_impact	1.74	0.64	neutral	0.45	neutral	2.58	20.00	deleterious	0.2	0.45	0.64	disease	0.63	disease	0.65	disease	0.74	disease	5	0.75	neutral	0.51	deleterious	-6	neutral	0.71	deleterious	-0.15	medium_impact	-0.09	medium_impact	0.39	medium_impact	0.75	0.85	27.36	14.7	0.32	N	0.60	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12460	12460	T	A	MI.19487	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	124	42	S	T	Tcc/Acc	-0.96	0	0	benign	0	neutral	0.45	neutral	3.83	neutral	-0.72	neutral	0.18	neutral_impact	-0.22	0.82	neutral	0.88	neutral	1.71	14.46	neutral	0.39	0.5	0.39	neutral	0.05	neutral	0.2	neutral	0.25	neutral	5	0.54	neutral	0.73	deleterious	-6	neutral	0.36	neutral	2.1	high_impact	0.18	medium_impact	-1.4	low_impact	0.77	0.85	27.36	14.7	0.53	N	0.22	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12461	12461	C	G	MI.19488	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	125	42	S	C	tCc/tGc	-2.57	0	0	benign	0	neutral	0.2	neutral	3.71	neutral	1.42	neutral	1.3	low_impact	0.93	0.87	neutral	0.98	neutral	1.91	15.67	deleterious	0.25	0.45	0.83	disease	0.38	neutral	0.28	neutral	0.64	disease	3	0.8	neutral	0.6	deleterious	-6	neutral	0.68	deleterious	2.1	high_impact	-0.1	medium_impact	-0.35	medium_impact	0.74	0.85	27.36	14.7	0.4	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12461	12461	C	A	MI.19489	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	125	42	S	Y	tCc/tAc	-2.57	0	0	benign	0	neutral	1	neutral	3.73	neutral	3.63	neutral	3.77	neutral_impact	-0.53	0.91	neutral	1	neutral	1.24	11.95	neutral	0.21	0.45	0.33	neutral	0.28	neutral	0.29	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.32	neutral	2.1	high_impact	1.89	high_impact	-1.69	low_impact	0.75	0.85	27.36	14.7	0.26	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5937	5937	C	T	MI.1949	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	34	12	H	Y	Cac/Tac	-1.72	0	0	probably_damaging	0.99	deleterious	0	neutral	-1.33	deleterious	-4.99	neutral	-1.06	high_impact	4.76	0.59	damaging	0.14	damaging	3.52	23.10	deleterious	0.38	0.55	0.88	disease	0.87	disease	0.64	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.64	low_impact	-1.48	low_impact	3.3	high_impact	0.38	0.9	2.34	6.67	0.69	P	0.72	disease_causing	0.98	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12461	12461	C	T	MI.19490	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	125	42	S	F	tCc/tTc	-2.57	0	0	benign	0	neutral	0.78	neutral	3.78	neutral	-0.11	neutral	2.31	low_impact	1.19	0.89	neutral	0.95	neutral	2.16	17.24	deleterious	0.25	0.45	0.72	disease	0.46	neutral	0.33	neutral	0.63	disease	3	0.22	neutral	0.89	deleterious	-6	neutral	0.21	neutral	2.1	high_impact	0.54	medium_impact	-0.12	medium_impact	0.61	0.8	27.36	14.7	0.27	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12463	12463	A	G	MI.19491	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	127	43	T	A	Acc/Gcc	-9.68	0	0	benign	0	neutral	0.98	neutral	3.83	neutral	5.92	neutral	2.4	neutral_impact	-0.88	0.83	neutral	0.98	neutral	-0.90	0.03	neutral	0.68	0.7	0.31	neutral	0.05	neutral	0.22	neutral	0.24	neutral	5	0	neutral	0.99	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	1.17	medium_impact	-2.01	low_impact	0.44	0.8	14.93	11.68	0.35	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12463	12463	A	C	MI.19492	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	127	43	T	P	Acc/Ccc	-9.68	0	0	possibly_damaging	0.52	neutral	0.36	neutral	3.65	neutral	-2.01	neutral	-1.56	low_impact	1.54	0.59	damaging	0.46	neutral	3.44	23.00	deleterious	0.18	0.45	0.43	neutral	0.82	disease	0.71	disease	0.78	disease	6	0.63	neutral	0.42	neutral	-3	neutral	0.69	deleterious	-0.78	medium_impact	0.1	medium_impact	0.2	medium_impact	0.72	0.85	14.93	11.68	0.29	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12463	12463	A	T	MI.19493	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	127	43	T	S	Acc/Tcc	-9.68	0	0	benign	0.17	neutral	1	neutral	3.76	neutral	0.28	neutral	1.06	neutral_impact	0.32	0.83	neutral	0.97	neutral	0.40	6.57	deleterious	0.56	0.6	0.4	neutral	0.22	neutral	0.25	neutral	0.38	neutral	2	0.17	neutral	0.92	deleterious	-6	neutral	0.34	neutral	-0.09	medium_impact	1.89	high_impact	-0.91	medium_impact	0.79	0.85	14.93	11.68	0.29	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12464	12464	C	G	MI.19494	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	128	43	T	S	aCc/aGc	-0.27	0	0	benign	0.17	neutral	1	neutral	3.76	neutral	0.28	neutral	1.06	neutral_impact	0.32	0.83	neutral	0.97	neutral	0.10	3.61	deleterious	0.56	0.6	0.4	neutral	0.22	neutral	0.25	neutral	0.38	neutral	2	0.17	neutral	0.92	deleterious	-6	neutral	0.34	neutral	-0.09	medium_impact	1.89	high_impact	-0.91	medium_impact	0.79	0.85	14.93	11.68	0.27	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12464	12464	C	A	MI.19495	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	128	43	T	N	aCc/aAc	-0.27	0	0	possibly_damaging	0.6	neutral	0.61	neutral	3.65	neutral	-1.9	neutral	-1.74	low_impact	1.9	0.65	neutral	0.6	neutral	3.14	22.60	deleterious	0.53	0.6	0.59	disease	0.7	disease	0.59	disease	0.69	disease	4	0.53	neutral	0.51	deleterious	-3	neutral	0.64	deleterious	-0.91	medium_impact	0.34	medium_impact	0.53	medium_impact	0.87	0.9	14.93	11.68	0.24	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12464	12464	C	T	MI.19496	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	128	43	T	I	aCc/aTc	-0.27	0	0	benign	0.31	neutral	0.57	neutral	3.73	neutral	-2.52	neutral	-1.77	low_impact	1.9	0.71	neutral	0.66	neutral	2.17	17.28	deleterious	0.49	0.55	0.74	disease	0.64	disease	0.56	disease	0.68	disease	4	0.34	neutral	0.63	deleterious	-6	neutral	0.59	deleterious	-0.42	medium_impact	0.3	medium_impact	0.53	medium_impact	0.75	0.85	14.93	11.68	0.25	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12466	12466	T	G	MI.19497	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	130	44	F	V	Ttt/Gtt	-10.37	0	0	possibly_damaging	0.52	neutral	0.51	neutral	3.55	deleterious	-7.59	deleterious	-6.1	medium_impact	3.25	0.67	neutral	0.16	damaging	3.84	23.40	deleterious	0.31	0.45	0.34	neutral	0.87	disease	0.7	disease	0.76	disease	5	0.51	neutral	0.5	deleterious	0	NA	0.76	deleterious	-0.78	medium_impact	0.24	medium_impact	1.77	medium_impact	0.71	0.85	6.97	11.34	0.26	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12466	12466	T	C	MI.19498	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	130	44	F	L	Ttt/Ctt	-10.37	0	0	benign	0.03	neutral	0.65	neutral	3.59	deleterious	-5.87	deleterious	-4.96	medium_impact	2.45	0.74	neutral	0.38	neutral	3.72	23.30	deleterious	0.43	0.55	0.19	neutral	0.75	disease	0.61	disease	0.52	disease	0	0.3	neutral	0.81	deleterious	-3	neutral	0.70	deleterious	0.69	medium_impact	0.38	medium_impact	1.04	medium_impact	0.77	0.85	6.97	11.34	0.32	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12466	12466	T	A	MI.19499	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	130	44	F	I	Ttt/Att	-10.37	0	0	possibly_damaging	0.52	neutral	0.41	neutral	3.52	deleterious	-7.44	deleterious	-5.13	medium_impact	3.25	0.69	neutral	0.17	damaging	4.16	23.80	deleterious	0.19	0.45	0.38	neutral	0.82	disease	0.7	disease	0.73	disease	5	0.58	neutral	0.45	neutral	0	NA	0.77	deleterious	-0.78	medium_impact	0.15	medium_impact	1.77	medium_impact	0.68	0.85	6.97	11.34	0.28	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8618	8618	T	C	MI.195	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	92	31	I	T	aTc/aCc	-0.33	0	0.01	benign	0.08	neutral	0.06	neutral	4.38	neutral	-0.72	neutral	-2.08	low_impact	1.62	0.91	neutral	0.77	neutral	0.29	5.55	deleterious	0.42	0.65	0.31	neutral	0.41	neutral	0.23	neutral	0.46	neutral	1	0.93	neutral	0.49	deleterious	-6	neutral	0.18	neutral	0.25	medium_impact	-0.38	medium_impact	0.29	medium_impact	0.33	0.9	28.32	22.32	0.48	N	0.39	polymorphism	1	0.02	rs28358885	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5937	5937	C	A	MI.1950	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	34	12	H	N	Cac/Aac	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	-1.34	deleterious	-3.82	neutral	-1.23	high_impact	4.42	0.61	neutral	0.11	damaging	3.83	23.40	deleterious	0.36	0.55	0.57	disease	0.88	disease	0.65	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.34	0.9	2.34	6.67	0.43	N	0.86	disease_causing	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12467	12467	T	C	MI.19500	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	131	44	F	S	tTt/tCt	4.31	1	0	possibly_damaging	0.89	neutral	0.42	neutral	3.48	deleterious	-8.75	deleterious	-7.22	medium_impact	3.25	0.69	neutral	0.14	damaging	4.00	23.60	deleterious	0.37	0.5	0.5	disease	0.85	disease	0.68	disease	0.75	disease	5	0.89	neutral	0.27	neutral	0	NA	0.81	deleterious	-1.61	low_impact	0.16	medium_impact	1.77	medium_impact	0.69	0.85	6.97	11.34	0.42	N	0.99	polymorphism	0.98	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12467	12467	T	A	MI.19501	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	131	44	F	Y	tTt/tAt	4.31	1	0	possibly_damaging	0.81	neutral	1	neutral	3.46	deleterious	-5.75	deleterious	-2.75	medium_impact	3.25	0.71	neutral	0.17	damaging	3.98	23.60	deleterious	0.35	0.5	0.67	disease	0.76	disease	0.7	disease	0.72	disease	4	0.81	neutral	0.6	deleterious	0	NA	0.80	deleterious	-1.34	low_impact	1.89	high_impact	1.77	medium_impact	0.76	0.85	6.97	11.34	0.46	N	0.88	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12467	12467	T	G	MI.19502	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	131	44	F	C	tTt/tGt	4.31	1	0	probably_damaging	0.96	neutral	0.18	neutral	3.44	deleterious	-10.18	deleterious	-7.14	medium_impact	2.7	0.66	neutral	0.21	damaging	3.90	23.50	deleterious	0.24	0.45	0.77	disease	0.83	disease	0.64	disease	0.67	disease	3	0.98	neutral	0.11	neutral	1	deleterious	0.82	deleterious	-2.06	low_impact	-0.13	medium_impact	1.26	medium_impact	0.43	0.8	6.97	11.34	0.34	N	0.99	polymorphism	0.97	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12468	12468	T	G	MI.19503	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	132	44	F	L	ttT/ttG	5.69	1	0	benign	0.03	neutral	0.65	neutral	3.59	deleterious	-5.87	deleterious	-4.96	medium_impact	2.45	0.74	neutral	0.38	neutral	4.05	23.70	deleterious	0.43	0.55	0.19	neutral	0.75	disease	0.61	disease	0.52	disease	0	0.3	neutral	0.81	deleterious	-3	neutral	0.70	deleterious	0.69	medium_impact	0.38	medium_impact	1.04	medium_impact	0.77	0.85	6.97	11.34	0.5	N	0.91	polymorphism	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12468	12468	T	A	MI.19504	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	132	44	F	L	ttT/ttA	5.69	1	0	benign	0.03	neutral	0.65	neutral	3.59	deleterious	-5.87	deleterious	-4.96	medium_impact	2.45	0.74	neutral	0.38	neutral	4.17	23.80	deleterious	0.43	0.55	0.19	neutral	0.75	disease	0.61	disease	0.52	disease	0	0.3	neutral	0.81	deleterious	-3	neutral	0.70	deleterious	0.69	medium_impact	0.38	medium_impact	1.04	medium_impact	0.77	0.85	6.97	11.34	0.5	N	0.91	polymorphism	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12469	12469	A	G	MI.19505	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	133	45	I	V	Att/Gtt	-3.49	0	0.01	benign	0.01	neutral	0.95	neutral	3.79	neutral	-1.5	neutral	-0.29	low_impact	1.73	0.86	neutral	0.9	neutral	-0.18	1.19	neutral	0.64	0.7	0.49	neutral	0.21	neutral	0.3	neutral	0.36	neutral	3	0.02	neutral	0.97	deleterious	-6	neutral	0.15	neutral	1.15	medium_impact	0.94	medium_impact	0.38	medium_impact	0.68	0.85	16.75	12.35	0.3	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12469	12469	A	C	MI.19506	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	133	45	I	L	Att/Ctt	-3.49	0	0.01	benign	0.03	neutral	1	neutral	3.88	neutral	-0.83	neutral	0.19	neutral_impact	0.58	0.81	neutral	0.94	neutral	-0.08	1.87	neutral	0.36	0.5	0.33	neutral	0.15	neutral	0.22	neutral	0.28	neutral	4	0.03	neutral	0.99	deleterious	-6	neutral	0.12	neutral	0.69	medium_impact	1.89	high_impact	-0.67	medium_impact	0.79	0.85	16.75	12.35	0.3	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12469	12469	A	T	MI.19507	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	133	45	I	F	Att/Ttt	-3.49	0	0.01	benign	0.28	neutral	0.84	neutral	3.72	neutral	-2.81	neutral	-1.22	neutral_impact	0.33	0.81	neutral	0.94	neutral	-1.07	0.01	neutral	0.46	0.55	0.67	disease	0.16	neutral	0.19	neutral	0.36	neutral	3	0.17	neutral	0.78	deleterious	-6	neutral	0.33	neutral	-0.36	medium_impact	0.63	medium_impact	-0.9	medium_impact	0.84	0.9	16.75	12.35	0.32	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12470	12470	T	G	MI.19508	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	134	45	I	S	aTt/aGt	-0.5	0	0	benign	0.12	neutral	0.73	neutral	3.65	deleterious	-3.44	neutral	-2.03	medium_impact	2.08	0.82	neutral	0.66	neutral	2.08	16.69	deleterious	0.34	0.5	0.34	neutral	0.59	disease	0.53	disease	0.62	disease	2	0.16	neutral	0.81	deleterious	-3	neutral	0.24	neutral	0.08	medium_impact	0.47	medium_impact	0.7	medium_impact	0.78	0.85	16.75	12.35	0.24	N	0.35	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12470	12470	T	C	MI.19509	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	134	45	I	T	aTt/aCt	-0.5	0	0	benign	0	neutral	0.46	neutral	3.66	neutral	-1.61	neutral	-1.19	neutral_impact	0.14	0.9	neutral	0.98	neutral	-0.17	1.28	neutral	0.51	0.6	0.5	neutral	0.24	neutral	0.33	neutral	0.3	neutral	4	0.53	neutral	0.73	deleterious	-6	neutral	0.17	neutral	2.1	high_impact	0.19	medium_impact	-1.08	low_impact	0.78	0.85	16.75	12.35	0.36	N	0.06	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5937	5937	C	G	MI.1951	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	34	12	H	D	Cac/Gac	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	-1.33	deleterious	-3.87	neutral	-1.58	high_impact	4.76	0.67	neutral	0.13	damaging	3.68	23.30	deleterious	0.18	0.55	0.68	disease	0.87	disease	0.72	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.34	0.9	2.34	6.67	0.71	P	0.97	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12470	12470	T	A	MI.19510	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	134	45	I	N	aTt/aAt	-0.5	0	0	benign	0.36	neutral	0.37	neutral	3.6	deleterious	-4.64	deleterious	-3.24	medium_impact	2.08	0.69	neutral	0.53	neutral	2.25	17.82	deleterious	0.32	0.5	0.75	disease	0.61	disease	0.56	disease	0.72	disease	4	0.56	neutral	0.51	deleterious	-3	neutral	0.43	neutral	-0.51	medium_impact	0.11	medium_impact	0.7	medium_impact	0.81	0.85	16.75	12.35	0.29	N	0.51	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12471	12471	T	A	MI.19511	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	135	45	I	M	atT/atA	0.87	0	0	benign	0.05	neutral	0.25	neutral	3.66	neutral	-0.08	neutral	0.12	neutral_impact	0.14	0.86	neutral	0.99	neutral	0.08	3.35	deleterious	0.55	0.6	0.63	disease	0.16	neutral	0.23	neutral	0.43	neutral	1	0.73	neutral	0.6	deleterious	-6	neutral	0.16	neutral	0.47	medium_impact	-0.03	medium_impact	-1.08	low_impact	0.86	0.9	16.75	12.35	0.49	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12471	12471	T	G	MI.19512	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	135	45	I	M	atT/atG	0.87	0	0	benign	0.05	neutral	0.25	neutral	3.66	neutral	-0.08	neutral	0.12	neutral_impact	0.14	0.86	neutral	0.99	neutral	-0.25	0.87	neutral	0.55	0.6	0.63	disease	0.16	neutral	0.23	neutral	0.43	neutral	1	0.73	neutral	0.6	deleterious	-6	neutral	0.16	neutral	0.47	medium_impact	-0.03	medium_impact	-1.08	low_impact	0.86	0.9	16.75	12.35	0.47	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12472	12472	A	T	MI.19513	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	136	46	I	F	Atc/Ttc	-13.81	0	0	benign	0.01	neutral	0.86	neutral	3.63	deleterious	-4.46	neutral	-1.71	medium_impact	2.68	0.84	neutral	0.82	neutral	3.11	22.50	deleterious	0.47	0.55	0.48	neutral	0.65	disease	0.36	neutral	0.52	disease	0	0.12	neutral	0.93	deleterious	-3	neutral	0.59	deleterious	1.15	medium_impact	0.67	medium_impact	1.25	medium_impact	0.84	0.9	7.79	10.5	0.25	N	0.56	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12472	12472	A	C	MI.19514	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	136	46	I	L	Atc/Ctc	-13.81	0	0	benign	0	neutral	0.76	neutral	3.83	neutral	-1.77	neutral	-0.47	medium_impact	2.34	0.89	neutral	0.95	neutral	0.36	6.23	deleterious	0.39	0.5	0.28	neutral	0.41	neutral	0.3	neutral	0.46	neutral	1	0.23	neutral	0.88	deleterious	-3	neutral	0.17	neutral	2.1	high_impact	0.51	medium_impact	0.94	medium_impact	0.81	0.85	7.79	10.5	0.39	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12472	12472	A	G	MI.19515	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	136	46	I	V	Atc/Gtc	-13.81	0	0	benign	0	neutral	0.53	neutral	3.77	neutral	-1.39	neutral	-0.23	medium_impact	2.06	0.87	neutral	0.96	neutral	-0.89	0.03	neutral	0.64	0.7	0.28	neutral	0.12	neutral	0.29	neutral	0.26	neutral	5	0.47	neutral	0.77	deleterious	-3	neutral	0.10	neutral	2.1	high_impact	0.26	medium_impact	0.68	medium_impact	0.80	0.85	7.79	10.5	0.44	N	0.67	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12473	12473	T	A	MI.19516	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	137	46	I	N	aTc/aAc	-0.04	0	0	benign	0.27	neutral	0.37	neutral	3.57	deleterious	-5.9	deleterious	-3.66	medium_impact	3.02	0.7	neutral	0.44	neutral	3.97	23.60	deleterious	0.3	0.45	0.33	neutral	0.71	disease	0.6	disease	0.72	disease	4	0.55	neutral	0.55	deleterious	-3	neutral	0.65	deleterious	-0.34	medium_impact	0.11	medium_impact	1.56	medium_impact	0.80	0.85	7.79	10.5	0.37	N	0.86	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12473	12473	T	C	MI.19517	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	137	46	I	T	aTc/aCc	-0.04	0	0	benign	0.01	neutral	0.43	neutral	3.64	neutral	-0.52	neutral	-0.86	low_impact	1.28	0.91	neutral	0.99	neutral	-0.49	0.23	neutral	0.44	0.55	0.18	neutral	0.22	neutral	0.34	neutral	0.37	neutral	3	0.56	neutral	0.71	deleterious	-6	neutral	0.40	neutral	1.15	medium_impact	0.17	medium_impact	-0.03	medium_impact	0.80	0.85	7.79	10.5	0.41	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12473	12473	T	G	MI.19518	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	137	46	I	S	aTc/aGc	-0.04	0	0	benign	0.08	neutral	0.52	neutral	3.63	deleterious	-4.78	deleterious	-2.67	medium_impact	2.68	0.81	neutral	0.61	neutral	2.39	18.78	deleterious	0.32	0.5	0.49	neutral	0.71	disease	0.58	disease	0.69	disease	4	0.41	neutral	0.72	deleterious	-3	neutral	0.57	deleterious	0.26	medium_impact	0.25	medium_impact	1.25	medium_impact	0.77	0.85	7.79	10.5	0.27	N	0.67	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12474	12474	C	A	MI.19519	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	138	46	I	M	atC/atA	-1.19	0	0	possibly_damaging	0.45	neutral	0.3	neutral	3.61	deleterious	-3.93	neutral	-1.02	medium_impact	2.34	0.83	neutral	0.88	neutral	2.15	17.16	deleterious	0.46	0.55	0.57	disease	0.35	neutral	0.32	neutral	0.61	disease	2	0.66	neutral	0.43	neutral	0	NA	0.58	deleterious	-0.66	medium_impact	0.03	medium_impact	0.94	medium_impact	0.86	0.9	7.79	10.5	0.45	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5938	5938	A	C	MI.1952	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	35	12	H	P	cAc/cCc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	-1.34	deleterious	-4.89	neutral	-1.76	high_impact	3.8	0.59	damaging	0.13	damaging	3.03	22.30	deleterious	0.17	0.55	0.85	disease	0.9	disease	0.68	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	2.41	high_impact	0.29	0.9	2.34	6.67	0.45	N	0.90	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12474	12474	C	G	MI.19520	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	138	46	I	M	atC/atG	-1.19	0	0	possibly_damaging	0.45	neutral	0.3	neutral	3.61	deleterious	-3.93	neutral	-1.02	medium_impact	2.34	0.83	neutral	0.88	neutral	1.72	14.52	neutral	0.46	0.55	0.57	disease	0.35	neutral	0.32	neutral	0.61	disease	2	0.66	neutral	0.43	neutral	0	NA	0.58	deleterious	-0.66	medium_impact	0.03	medium_impact	0.94	medium_impact	0.86	0.9	7.79	10.5	0.45	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12475	12475	A	G	MI.19521	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	139	47	S	G	Agt/Ggt	-10.6	0	0	benign	0.4	neutral	0.33	neutral	3.53	deleterious	-6.69	deleterious	-3.81	medium_impact	3.25	0.67	neutral	0.54	neutral	3.35	22.90	deleterious	0.36	0.5	0.78	disease	0.67	disease	0.65	disease	0.69	disease	4	0.62	neutral	0.47	neutral	-3	neutral	0.76	deleterious	-0.58	medium_impact	0.06	medium_impact	1.77	medium_impact	0.74	0.85	21.89	7.46	0.33	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12475	12475	A	T	MI.19522	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	139	47	S	C	Agt/Tgt	-10.6	0	0	probably_damaging	0.96	neutral	0.18	neutral	3.52	deleterious	-8.45	deleterious	-4.36	medium_impact	3.25	0.7	neutral	0.47	neutral	3.16	22.60	deleterious	0.24	0.45	0.83	disease	0.76	disease	0.59	disease	0.71	disease	4	0.98	neutral	0.11	neutral	1	deleterious	0.79	deleterious	-2.06	low_impact	-0.13	medium_impact	1.77	medium_impact	0.74	0.85	21.89	7.46	0.31	N	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12475	12475	A	C	MI.19523	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	139	47	S	R	Agt/Cgt	-10.6	0	0	possibly_damaging	0.85	neutral	0.35	neutral	3.53	deleterious	-7.88	deleterious	-4.71	medium_impact	3.25	0.64	neutral	0.47	neutral	3.58	23.20	deleterious	0.14	0.4	0.75	disease	0.86	disease	0.77	disease	0.79	disease	6	0.87	neutral	0.25	neutral	0	NA	0.85	deleterious	-1.46	low_impact	0.08	medium_impact	1.77	medium_impact	0.81	0.85	21.89	7.46	0.39	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12476	12476	G	C	MI.19524	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	140	47	S	T	aGt/aCt	5.23	1	0	possibly_damaging	0.61	neutral	0.4	neutral	3.6	deleterious	-6.45	deleterious	-2.81	medium_impact	2.44	0.67	neutral	0.57	neutral	3.21	22.70	deleterious	0.36	0.5	0.51	disease	0.56	disease	0.57	disease	0.49	neutral	0	0.64	neutral	0.4	neutral	0	NA	0.76	deleterious	-0.93	medium_impact	0.14	medium_impact	1.03	medium_impact	0.84	0.9	21.89	7.46	0.51	P	0.70	disease_causing	0.91	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12476	12476	G	T	MI.19525	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	140	47	S	I	aGt/aTt	5.23	1	0	probably_damaging	0.92	neutral	0.4	neutral	3.58	deleterious	-6.64	deleterious	-5.62	medium_impact	2.9	0.7	neutral	0.56	neutral	3.95	23.60	deleterious	0.29	0.45	0.45	neutral	0.88	disease	0.67	disease	0.76	disease	5	0.92	neutral	0.24	neutral	1	deleterious	0.77	deleterious	-1.75	low_impact	0.14	medium_impact	1.45	medium_impact	0.84	0.9	21.89	7.46	0.41	N	0.99	disease_causing	0.99	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12476	12476	G	A	MI.19526	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	140	47	S	N	aGt/aAt	5.23	1	0	benign	0.05	neutral	0.32	neutral	3.54	deleterious	-7.53	deleterious	-2.83	medium_impact	2.9	0.69	neutral	0.55	neutral	3.29	22.80	deleterious	0.61	0.65	0.78	disease	0.63	disease	0.61	disease	0.55	disease	1	0.65	neutral	0.64	deleterious	-3	neutral	0.78	deleterious	0.47	medium_impact	0.05	medium_impact	1.45	medium_impact	0.66	0.8	21.89	7.46	0.53	P	0.83	disease_causing	0.93	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12478	12478	C	A	MI.19527	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	142	48	L	I	Ctc/Atc	-0.04	0	0	benign	0.05	neutral	0.4	neutral	3.48	deleterious	-3.06	neutral	-1.35	medium_impact	3.06	0.8	neutral	0.55	neutral	3.79	23.40	deleterious	0.44	0.55	0.38	neutral	0.61	disease	0.38	neutral	0.45	neutral	1	0.56	neutral	0.68	deleterious	-3	neutral	0.73	deleterious	0.47	medium_impact	0.14	medium_impact	1.59	medium_impact	0.76	0.85	15.09	13.17	0.33	N	0.51	polymorphism	0.76	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12478	12478	C	T	MI.19528	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	142	48	L	F	Ctc/Ttc	-0.04	0	0	possibly_damaging	0.72	neutral	0.71	neutral	3.4	deleterious	-4.26	deleterious	-3	medium_impact	2.17	0.65	neutral	0.31	neutral	3.81	23.40	deleterious	0.46	0.55	0.66	disease	0.69	disease	0.55	disease	0.59	disease	2	0.67	neutral	0.5	deleterious	0	NA	0.79	deleterious	-1.14	low_impact	0.45	medium_impact	0.78	medium_impact	0.72	0.85	15.09	13.17	0.2	N	0.69	disease_causing	0.75	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12478	12478	C	G	MI.19529	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	142	48	L	V	Ctc/Gtc	-0.04	0	0	benign	0.2	neutral	0.5	neutral	3.47	deleterious	-3.27	neutral	-1.83	medium_impact	2.71	0.69	neutral	0.28	damaging	3.21	22.70	deleterious	0.48	0.55	0.47	neutral	0.6	disease	0.53	disease	0.53	disease	1	0.4	neutral	0.65	deleterious	-3	neutral	0.74	deleterious	-0.17	medium_impact	0.23	medium_impact	1.27	medium_impact	0.71	0.85	15.09	13.17	0.32	N	0.46	polymorphism	0.63	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5938	5938	A	G	MI.1953	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	35	12	H	R	cAc/cGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	-1.33	deleterious	-3.9	neutral	-1.41	high_impact	4.76	0.65	neutral	0.13	damaging	2.81	21.40	deleterious	0.33	0.55	0.74	disease	0.88	disease	0.64	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.38	0.9	2.34	6.67	0.72	P	0.85	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12479	12479	T	C	MI.19530	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	143	48	L	P	cTc/cCc	-0.04	0	0	possibly_damaging	0.87	neutral	0.2	neutral	3.33	deleterious	-6.63	deleterious	-5.16	medium_impact	3.06	0.57	damaging	0.15	damaging	3.69	23.30	deleterious	0.13	0.4	0.83	disease	0.81	disease	0.74	disease	0.79	disease	6	0.92	neutral	0.17	neutral	0	NA	0.87	deleterious	-1.53	low_impact	-0.1	medium_impact	1.59	medium_impact	0.63	0.8	15.09	13.17	0.27	N	0.96	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12479	12479	T	A	MI.19531	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	143	48	L	H	cTc/cAc	-0.04	0	0	probably_damaging	0.94	neutral	0.54	neutral	3.33	deleterious	-6.83	deleterious	-5.29	medium_impact	3.06	0.63	neutral	0.22	damaging	3.93	23.50	deleterious	0.2	0.45	0.83	disease	0.79	disease	0.71	disease	0.77	disease	5	0.93	neutral	0.3	neutral	1	deleterious	0.84	deleterious	-1.88	low_impact	0.27	medium_impact	1.59	medium_impact	0.69	0.85	15.09	13.17	0.25	N	0.86	disease_causing	0.68	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12479	12479	T	G	MI.19532	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	143	48	L	R	cTc/cGc	-0.04	0	0	possibly_damaging	0.83	neutral	0.35	neutral	3.34	deleterious	-6.05	deleterious	-4.34	medium_impact	3.06	0.55	damaging	0.19	damaging	3.99	23.60	deleterious	0.15	0.4	0.77	disease	0.89	disease	0.74	disease	0.81	disease	6	0.85	neutral	0.26	neutral	0	NA	0.89	deleterious	-1.4	low_impact	0.08	medium_impact	1.59	medium_impact	0.72	0.85	15.09	13.17	0.28	N	0.97	disease_causing	0.79	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12481	12481	T	C	MI.19533	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	145	49	F	L	Ttc/Ctc	-3.26	0	0	benign	0	neutral	1	neutral	3.77	neutral	-0.18	neutral	1.78	neutral_impact	-0.36	0.85	neutral	0.93	neutral	-0.40	0.39	neutral	0.46	0.55	0.23	neutral	0.15	neutral	0.24	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	1.89	high_impact	-1.53	low_impact	0.74	0.85	25.21	16.14	0.29	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12481	12481	T	A	MI.19534	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	145	49	F	I	Ttc/Atc	-3.26	0	0	benign	0	neutral	0.67	neutral	3.74	neutral	-0.49	neutral	3.17	neutral_impact	-0.9	0.85	neutral	0.99	neutral	-0.48	0.25	neutral	0.28	0.45	0.21	neutral	0.14	neutral	0.2	neutral	0.24	neutral	5	0.33	neutral	0.84	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.4	medium_impact	-2.03	low_impact	0.61	0.8	25.21	16.14	0.33	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12481	12481	T	G	MI.19535	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	145	49	F	V	Ttc/Gtc	-3.26	0	0	benign	0.01	neutral	0.54	neutral	3.68	neutral	-0.64	neutral	2.59	neutral_impact	0.45	0.85	neutral	0.99	neutral	0.50	7.46	deleterious	0.35	0.5	0.25	neutral	0.41	neutral	0.31	neutral	0.45	neutral	1	0.44	neutral	0.77	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.27	medium_impact	-0.79	medium_impact	0.57	0.8	25.21	16.14	0.29	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12482	12482	T	A	MI.19536	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	146	49	F	Y	tTc/tAc	-2.57	0	0	benign	0.19	neutral	0.72	neutral	3.6	neutral	-2.06	neutral	-0.85	low_impact	1.65	0.77	neutral	0.68	neutral	2.35	18.47	deleterious	0.37	0.5	0.55	disease	0.37	neutral	0.55	disease	0.63	disease	3	0.17	neutral	0.77	deleterious	-6	neutral	0.50	deleterious	-0.15	medium_impact	0.46	medium_impact	0.3	medium_impact	0.64	0.8	25.21	16.14	0.25	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12482	12482	T	C	MI.19537	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	146	49	F	S	tTc/tCc	-2.57	0	0	benign	0	neutral	0.63	neutral	3.6	neutral	-1.91	neutral	-1.82	low_impact	0.96	0.73	neutral	0.71	neutral	2.35	18.51	deleterious	0.36	0.5	0.31	neutral	0.49	neutral	0.56	disease	0.61	disease	2	0.36	neutral	0.82	deleterious	-6	neutral	0.46	deleterious	2.1	high_impact	0.36	medium_impact	-0.33	medium_impact	0.52	0.8	25.21	16.14	0.33	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12482	12482	T	G	MI.19538	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	146	49	F	C	tTc/tGc	-2.57	0	0	possibly_damaging	0.57	neutral	0.12	neutral	3.56	deleterious	-3.38	neutral	-1.01	low_impact	1.65	0.71	neutral	0.56	neutral	3.72	23.30	deleterious	0.27	0.45	0.67	disease	0.66	disease	0.57	disease	0.73	disease	5	0.88	neutral	0.28	neutral	-3	neutral	0.66	deleterious	-0.86	medium_impact	-0.25	medium_impact	0.3	medium_impact	0.40	0.8	25.21	16.14	0.35	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12483	12483	C	G	MI.19539	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	147	49	F	L	ttC/ttG	1.1	0.01	0	benign	0	neutral	1	neutral	3.77	neutral	-0.18	neutral	1.78	neutral_impact	-0.36	0.85	neutral	0.93	neutral	-0.01	2.51	deleterious	0.46	0.55	0.23	neutral	0.15	neutral	0.24	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	1.89	high_impact	-1.53	low_impact	0.74	0.85	25.21	16.14	0.3	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5938	5938	A	T	MI.1954	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	35	12	H	L	cAc/cTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	-1.34	deleterious	-4.26	neutral	-1.94	high_impact	4.42	0.65	neutral	0.13	damaging	3.71	23.30	deleterious	0.22	0.55	0.81	disease	0.92	disease	0.69	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.31	0.9	2.34	6.67	0.56	P	0.92	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12483	12483	C	A	MI.19540	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	147	49	F	L	ttC/ttA	1.1	0.01	0	benign	0	neutral	1	neutral	3.77	neutral	-0.18	neutral	1.78	neutral_impact	-0.36	0.85	neutral	0.93	neutral	0.27	5.42	deleterious	0.46	0.55	0.23	neutral	0.15	neutral	0.24	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	1.89	high_impact	-1.53	low_impact	0.74	0.85	25.21	16.14	0.3	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12484	12484	C	G	MI.19541	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	148	50	P	A	Ccc/Gcc	-11.28	0	0	benign	0.3	neutral	0.45	neutral	3.79	neutral	0.8	deleterious	-7.39	medium_impact	2.31	0.71	neutral	0.53	neutral	2.85	21.60	deleterious	0.35	0.5	0.46	neutral	0.53	disease	0.58	disease	0.48	neutral	0	0.46	neutral	0.58	deleterious	-3	neutral	0.72	deleterious	-0.4	medium_impact	0.18	medium_impact	0.91	medium_impact	0.80	0.85	10.95	14.85	0.37	N	0.51	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12484	12484	C	T	MI.19542	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	148	50	P	S	Ccc/Tcc	-11.28	0	0	benign	0.03	neutral	0.61	neutral	3.76	neutral	0.23	deleterious	-7.27	medium_impact	2	0.74	neutral	0.55	neutral	2.62	20.30	deleterious	0.44	0.55	0.22	neutral	0.71	disease	0.56	disease	0.5	disease	0	0.34	neutral	0.79	deleterious	-3	neutral	0.72	deleterious	0.69	medium_impact	0.34	medium_impact	0.62	medium_impact	0.42	0.8	10.95	14.85	0.34	N	0.38	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12484	12484	C	A	MI.19543	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	148	50	P	T	Ccc/Acc	-11.28	0	0	benign	0.03	neutral	0.47	neutral	3.72	neutral	-0.42	deleterious	-7.39	medium_impact	2.86	0.66	neutral	0.38	neutral	3.47	23.00	deleterious	0.29	0.45	0.42	neutral	0.73	disease	0.58	disease	0.62	disease	2	0.5	neutral	0.72	deleterious	-3	neutral	0.76	deleterious	0.69	medium_impact	0.2	medium_impact	1.41	medium_impact	0.77	0.85	10.95	14.85	0.34	N	0.70	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12485	12485	C	A	MI.19544	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	149	50	P	H	cCc/cAc	4.31	0.99	0	probably_damaging	0.94	neutral	0.46	neutral	3.66	neutral	-2.22	deleterious	-8.43	medium_impact	3.21	0.64	neutral	0.36	neutral	3.84	23.40	deleterious	0.31	0.45	0.63	disease	0.83	disease	0.75	disease	0.79	disease	6	0.93	neutral	0.26	neutral	1	deleterious	0.80	deleterious	-1.88	low_impact	0.19	medium_impact	1.73	medium_impact	0.66	0.8	10.95	14.85	0.47	N	0.85	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12485	12485	C	G	MI.19545	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	149	50	P	R	cCc/cGc	4.31	0.99	0	possibly_damaging	0.78	neutral	0.28	neutral	3.68	neutral	-1.21	deleterious	-8.43	medium_impact	3.21	0.65	neutral	0.37	neutral	3.39	23.00	deleterious	0.24	0.45	0.52	disease	0.89	disease	0.78	disease	0.8	disease	6	0.84	neutral	0.25	neutral	0	NA	0.82	deleterious	-1.27	low_impact	0.01	medium_impact	1.73	medium_impact	0.66	0.8	10.95	14.85	0.55	P	0.92	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12485	12485	C	T	MI.19546	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	149	50	P	L	cCc/cTc	4.31	0.99	0	benign	0.4	neutral	0.99	neutral	3.82	neutral	0.95	deleterious	-9.36	medium_impact	3.21	0.64	neutral	0.35	neutral	4.21	23.90	deleterious	0.41	0.5	0.59	disease	0.82	disease	0.62	disease	0.66	disease	3	0.39	neutral	0.8	deleterious	-3	neutral	0.78	deleterious	-0.58	medium_impact	1.33	medium_impact	1.73	medium_impact	0.80	0.85	10.95	14.85	0.38	N	0.89	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12487	12487	A	T	MI.19547	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	151	51	T	S	Aca/Tca	-6.01	0	0	possibly_damaging	0.57	neutral	0.57	neutral	3.74	neutral	-0.71	neutral	-1.63	medium_impact	2.37	0.85	neutral	0.76	neutral	3.22	22.80	deleterious	0.52	0.6	0.38	neutral	0.32	neutral	0.51	disease	0.47	neutral	1	0.52	neutral	0.5	deleterious	0	NA	0.67	deleterious	-0.86	medium_impact	0.3	medium_impact	0.96	medium_impact	0.84	0.9	16.58	14.93	0.28	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12487	12487	A	C	MI.19548	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	151	51	T	P	Aca/Cca	-6.01	0	0	possibly_damaging	0.88	neutral	0.3	neutral	3.67	neutral	-2.36	deleterious	-3.34	medium_impact	2.17	0.63	neutral	0.66	neutral	3.34	22.90	deleterious	0.17	0.45	0.73	disease	0.74	disease	0.65	disease	0.72	disease	4	0.9	neutral	0.21	neutral	0	NA	0.81	deleterious	-1.57	low_impact	0.03	medium_impact	0.78	medium_impact	0.69	0.85	16.58	14.93	0.28	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12487	12487	A	G	MI.19549	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	151	51	T	A	Aca/Gca	-6.01	0	0	benign	0.3	neutral	0.6	neutral	3.77	neutral	-0.1	neutral	-1.48	low_impact	1.68	0.85	neutral	0.93	neutral	2.10	16.84	deleterious	0.61	0.65	0.46	neutral	0.23	neutral	0.32	neutral	0.44	neutral	1	0.3	neutral	0.65	deleterious	-6	neutral	0.66	deleterious	-0.4	medium_impact	0.33	medium_impact	0.33	medium_impact	0.33	0.8	16.58	14.93	0.32	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5939	5939	C	G	MI.1955	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	36	12	H	Q	caC/caG	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-1.34	deleterious	-3.97	neutral	-1.41	high_impact	4.76	0.67	neutral	0.14	damaging	3.36	22.90	deleterious	0.3	0.55	0.75	disease	0.83	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.42	0.9	2.34	6.67	0.72	P	0.83	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12488	12488	C	A	MI.19550	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	152	51	T	K	aCa/aAa	-0.27	0	0	possibly_damaging	0.69	neutral	0.34	neutral	3.68	neutral	-1.84	deleterious	-3.01	medium_impact	2.71	0.71	neutral	0.53	neutral	4.24	23.90	deleterious	0.21	0.45	0.42	neutral	0.65	disease	0.67	disease	0.74	disease	5	0.74	neutral	0.33	neutral	0	NA	0.73	deleterious	-1.08	low_impact	0.07	medium_impact	1.27	medium_impact	0.75	0.85	16.58	14.93	0.34	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12488	12488	C	T	MI.19551	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	152	51	T	M	aCa/aTa	-0.27	0	0	benign	0.06	neutral	0.37	neutral	3.72	neutral	-1.21	neutral	-1.26	low_impact	1.15	0.88	neutral	0.98	neutral	2.46	19.19	deleterious	0.4	0.5	0.68	disease	0.21	neutral	0.28	neutral	0.48	neutral	1	0.59	neutral	0.66	deleterious	-6	neutral	0.69	deleterious	0.39	medium_impact	0.11	medium_impact	-0.15	medium_impact	0.72	0.85	16.58	14.93	0.4	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12490	12490	A	G	MI.19552	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	154	52	T	A	Aca/Gca	-5.78	0	0.01	benign	0.01	neutral	0.42	neutral	3.78	neutral	-0.15	neutral	-0.7	low_impact	1.64	0.82	neutral	0.87	neutral	0.14	4.00	deleterious	0.62	0.65	0.3	neutral	0.18	neutral	0.42	neutral	0.36	neutral	3	0.57	neutral	0.71	deleterious	-6	neutral	0.33	neutral	1.15	medium_impact	0.16	medium_impact	0.3	medium_impact	0.61	0.8	25.37	15.62	0.39	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12490	12490	A	C	MI.19553	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	154	52	T	P	Aca/Cca	-5.78	0	0.01	possibly_damaging	0.63	neutral	0.26	neutral	3.69	neutral	-2.2	neutral	-2.28	medium_impact	2.33	0.67	neutral	0.42	neutral	3.04	22.40	deleterious	0.16	0.45	0.73	disease	0.68	disease	0.56	disease	0.71	disease	4	0.76	neutral	0.32	neutral	0	NA	0.72	deleterious	-0.97	medium_impact	-0.02	medium_impact	0.93	medium_impact	0.74	0.85	25.37	15.62	0.29	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12490	12490	A	T	MI.19554	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	154	52	T	S	Aca/Tca	-5.78	0	0.01	benign	0.12	neutral	0.67	neutral	3.77	neutral	-0.29	neutral	-1.08	low_impact	1.36	0.85	neutral	0.88	neutral	0.17	4.39	deleterious	0.54	0.6	0.46	neutral	0.2	neutral	0.29	neutral	0.37	neutral	3	0.22	neutral	0.78	deleterious	-6	neutral	0.39	neutral	0.08	medium_impact	0.4	medium_impact	0.04	medium_impact	0.83	0.9	25.37	15.62	0.33	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12491	12491	C	A	MI.19555	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	155	52	T	K	aCa/aAa	-1.65	0	0	benign	0.36	neutral	0.3	neutral	3.7	neutral	-1.77	neutral	-1.58	medium_impact	2.33	0.76	neutral	0.56	neutral	2.64	20.50	deleterious	0.23	0.45	0.65	disease	0.58	disease	0.56	disease	0.69	disease	4	0.64	neutral	0.47	deleterious	-3	neutral	0.54	deleterious	-0.51	medium_impact	0.03	medium_impact	0.93	medium_impact	0.79	0.85	25.37	15.62	0.31	N	0.73	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12491	12491	C	T	MI.19556	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	155	52	T	M	aCa/aTa	-1.65	0	0	benign	0.03	neutral	0.42	neutral	3.75	neutral	-1.11	neutral	2.13	neutral_impact	-0.18	0.89	neutral	0.99	neutral	-0.89	0.03	neutral	0.37	0.5	0.36	neutral	0.13	neutral	0.25	neutral	0.26	neutral	5	0.55	neutral	0.7	deleterious	-6	neutral	0.20	neutral	0.69	medium_impact	0.16	medium_impact	-1.37	low_impact	0.77	0.85	25.37	15.62	0.39	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12493	12493	A	T	MI.19557	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	157	53	M	L	Ata/Tta	-3.03	0	0	benign	0	neutral	1	neutral	4	neutral	1.35	neutral	-1.32	low_impact	0.88	0.86	neutral	0.94	neutral	-1.29	0.01	neutral	0.59	0.65	0.21	neutral	0.21	neutral	0.34	neutral	0.35	neutral	3	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	1.89	high_impact	-0.4	medium_impact	0.58	0.8	17.25	12.16	0.36	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12493	12493	A	C	MI.19558	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	157	53	M	L	Ata/Cta	-3.03	0	0	benign	0	neutral	1	neutral	4	neutral	1.35	neutral	-1.32	low_impact	0.88	0.86	neutral	0.94	neutral	-1.47	0.00	neutral	0.59	0.65	0.21	neutral	0.21	neutral	0.34	neutral	0.35	neutral	3	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	1.89	high_impact	-0.4	medium_impact	0.58	0.8	17.25	12.16	0.35	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12493	12493	A	G	MI.19559	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	157	53	M	V	Ata/Gta	-3.03	0	0	benign	0.05	neutral	0.52	neutral	3.86	neutral	0.45	neutral	-1.86	medium_impact	2.06	0.84	neutral	0.86	neutral	-0.53	0.18	neutral	0.54	0.6	0.45	neutral	0.52	disease	0.44	neutral	0.48	neutral	0	0.43	neutral	0.74	deleterious	-3	neutral	0.21	neutral	0.47	medium_impact	0.25	medium_impact	0.68	medium_impact	0.55	0.8	17.25	12.16	0.31	N	0.42	polymorphism	1	0.03	.	Uncertain_significance	not_provided	439306	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5939	5939	C	A	MI.1956	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	36	12	H	Q	caC/caA	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-1.34	deleterious	-3.97	neutral	-1.41	high_impact	4.76	0.67	neutral	0.14	damaging	3.73	23.30	deleterious	0.3	0.55	0.75	disease	0.83	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.42	0.9	2.34	6.67	0.72	P	0.83	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12494	12494	T	A	MI.19560	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	158	53	M	K	aTa/aAa	-2.11	0	0	benign	0.29	neutral	0.29	neutral	3.73	neutral	-0.85	deleterious	-4.12	medium_impact	2.61	0.74	neutral	0.55	neutral	2.14	17.11	deleterious	0.31	0.45	0.77	disease	0.77	disease	0.71	disease	0.79	disease	6	0.65	neutral	0.5	deleterious	-3	neutral	0.48	deleterious	-0.38	medium_impact	0.02	medium_impact	1.18	medium_impact	0.55	0.8	17.25	12.16	0.3	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12494	12494	T	C	MI.19561	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	158	53	M	T	aTa/aCa	-2.11	0	0	benign	0.15	neutral	0.49	neutral	3.78	neutral	-0.47	deleterious	-2.93	low_impact	1.17	0.85	neutral	0.94	neutral	-0.31	0.63	neutral	0.53	0.6	0.6	disease	0.45	neutral	0.44	neutral	0.61	disease	2	0.42	neutral	0.67	deleterious	-6	neutral	0.33	neutral	-0.03	medium_impact	0.22	medium_impact	-0.13	medium_impact	0.35	0.8	17.25	12.16	0.31	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12495	12495	A	T	MI.19562	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	159	53	M	I	atA/atT	0.64	0	0	benign	0.08	neutral	0.56	neutral	3.89	neutral	0.31	neutral	-1.78	low_impact	0.88	0.82	neutral	0.95	neutral	-1.37	0.00	neutral	0.58	0.65	0.34	neutral	0.24	neutral	0.31	neutral	0.45	neutral	1	0.36	neutral	0.74	deleterious	-6	neutral	0.16	neutral	0.26	medium_impact	0.29	medium_impact	-0.4	medium_impact	0.64	0.8	17.25	12.16	0.34	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12495	12495	A	C	MI.19563	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	159	53	M	I	atA/atC	0.64	0	0	benign	0.08	neutral	0.56	neutral	3.89	neutral	0.31	neutral	-1.78	low_impact	0.88	0.82	neutral	0.95	neutral	-1.44	0.00	neutral	0.58	0.65	0.34	neutral	0.24	neutral	0.31	neutral	0.45	neutral	1	0.36	neutral	0.74	deleterious	-6	neutral	0.16	neutral	0.26	medium_impact	0.29	medium_impact	-0.4	medium_impact	0.64	0.8	17.25	12.16	0.34	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12496	12496	T	A	MI.19564	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	160	54	F	I	Ttc/Atc	-3.26	0	0	possibly_damaging	0.62	neutral	0.5	neutral	3.6	neutral	-1.43	deleterious	-4.64	medium_impact	3.19	0.7	neutral	0.55	neutral	4.19	23.80	deleterious	0.28	0.45	0.48	neutral	0.85	disease	0.68	disease	0.75	disease	5	0.6	neutral	0.44	neutral	0	NA	0.75	deleterious	-0.95	medium_impact	0.23	medium_impact	1.71	medium_impact	0.51	0.8	11.44	12.6	0.31	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12496	12496	T	C	MI.19565	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	160	54	F	L	Ttc/Ctc	-3.26	0	0	benign	0.3	neutral	1	neutral	3.64	neutral	-0.77	deleterious	-4.38	medium_impact	2.64	0.77	neutral	0.85	neutral	3.77	23.40	deleterious	0.33	0.5	0.26	neutral	0.68	disease	0.48	neutral	0.49	neutral	0	0.29	neutral	0.85	deleterious	-3	neutral	0.69	deleterious	-0.4	medium_impact	1.89	high_impact	1.21	medium_impact	0.57	0.8	11.44	12.6	0.27	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12496	12496	T	G	MI.19566	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	160	54	F	V	Ttc/Gtc	-3.26	0	0	possibly_damaging	0.49	neutral	0.53	neutral	3.61	neutral	-1.13	deleterious	-5.55	medium_impact	3.19	0.71	neutral	0.5	neutral	3.87	23.50	deleterious	0.36	0.5	0.46	neutral	0.87	disease	0.69	disease	0.72	disease	4	0.47	neutral	0.52	deleterious	0	NA	0.76	deleterious	-0.73	medium_impact	0.26	medium_impact	1.71	medium_impact	0.54	0.8	11.44	12.6	0.29	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12497	12497	T	A	MI.19567	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	161	54	F	Y	tTc/tAc	2.25	0.06	0	benign	0.02	neutral	0.84	neutral	3.58	neutral	-1.7	neutral	-2.33	low_impact	1.91	0.85	neutral	0.92	neutral	3.04	22.40	deleterious	0.46	0.55	0.7	disease	0.64	disease	0.44	neutral	0.52	disease	0	0.11	neutral	0.91	deleterious	-6	neutral	0.77	deleterious	0.86	medium_impact	0.63	medium_impact	0.54	medium_impact	0.57	0.8	11.44	12.6	0.28	N	0.42	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12497	12497	T	C	MI.19568	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	161	54	F	S	tTc/tCc	2.25	0.06	0	possibly_damaging	0.69	neutral	0.65	neutral	3.54	neutral	-2.18	deleterious	-6.77	medium_impact	2.39	0.72	neutral	0.67	neutral	4.12	23.80	deleterious	0.36	0.5	0.59	disease	0.83	disease	0.68	disease	0.69	disease	4	0.63	neutral	0.48	deleterious	0	NA	0.80	deleterious	-1.08	low_impact	0.38	medium_impact	0.98	medium_impact	0.50	0.8	11.44	12.6	0.28	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12497	12497	T	G	MI.19569	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	161	54	F	C	tTc/tGc	2.25	0.06	0	probably_damaging	0.94	neutral	0.15	neutral	3.49	deleterious	-4.07	deleterious	-6.68	medium_impact	2.85	0.64	neutral	0.53	neutral	3.90	23.50	deleterious	0.26	0.45	0.8	disease	0.86	disease	0.64	disease	0.75	disease	5	0.97	neutral	0.11	neutral	1	deleterious	0.79	deleterious	-1.88	low_impact	-0.18	medium_impact	1.4	medium_impact	0.30	0.8	11.44	12.6	0.33	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5940	5940	A	C	MI.1957	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	37	13	K	Q	Aaa/Caa	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	-0.88	deleterious	-4.36	neutral	-0.75	high_impact	4.25	0.69	neutral	0.12	damaging	3.07	22.40	deleterious	0.38	0.55	0.65	disease	0.84	disease	0.64	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.71	0.9	3.31	6.65	0.39	N	0.64	polymorphism	0.96	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12498	12498	C	A	MI.19570	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	162	54	F	L	ttC/ttA	0.64	0.02	0.01	benign	0.3	neutral	1	neutral	3.64	neutral	-0.77	deleterious	-4.38	medium_impact	2.64	0.77	neutral	0.85	neutral	4.40	24.10	deleterious	0.33	0.5	0.26	neutral	0.68	disease	0.48	neutral	0.49	neutral	0	0.29	neutral	0.85	deleterious	-3	neutral	0.69	deleterious	-0.4	medium_impact	1.89	high_impact	1.21	medium_impact	0.57	0.8	11.44	12.6	0.28	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12498	12498	C	G	MI.19571	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	162	54	F	L	ttC/ttG	0.64	0.02	0.01	benign	0.3	neutral	1	neutral	3.64	neutral	-0.77	deleterious	-4.38	medium_impact	2.64	0.77	neutral	0.85	neutral	4.06	23.70	deleterious	0.33	0.5	0.26	neutral	0.68	disease	0.48	neutral	0.49	neutral	0	0.29	neutral	0.85	deleterious	-3	neutral	0.69	deleterious	-0.4	medium_impact	1.89	high_impact	1.21	medium_impact	0.57	0.8	11.44	12.6	0.28	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12499	12499	A	G	MI.19572	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	163	55	M	V	Atg/Gtg	-4.86	0	0	benign	0	neutral	0.59	neutral	3.85	neutral	1.08	neutral	0.42	low_impact	1.63	0.87	neutral	0.93	neutral	-0.38	0.43	neutral	0.62	0.65	0.33	neutral	0.51	disease	0.51	disease	0.5	neutral	0	0.41	neutral	0.8	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	0.32	medium_impact	0.29	medium_impact	0.52	0.8	17.25	12.35	0.29	N	0.28	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12499	12499	A	T	MI.19573	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	163	55	M	L	Atg/Ttg	-4.86	0	0	benign	0	neutral	1	neutral	3.97	neutral	1.79	neutral	0.89	neutral_impact	0.08	0.81	neutral	0.98	neutral	-1.43	0.00	neutral	0.56	0.6	0.19	neutral	0.19	neutral	0.25	neutral	0.35	neutral	3	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	1.89	high_impact	-1.13	low_impact	0.46	0.8	17.25	12.35	0.36	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12499	12499	A	C	MI.19574	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	163	55	M	L	Atg/Ctg	-4.86	0	0	benign	0	neutral	1	neutral	3.97	neutral	1.79	neutral	0.89	neutral_impact	0.08	0.81	neutral	0.98	neutral	-1.41	0.00	neutral	0.56	0.6	0.19	neutral	0.19	neutral	0.25	neutral	0.35	neutral	3	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	1.89	high_impact	-1.13	low_impact	0.46	0.8	17.25	12.35	0.36	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12500	12500	T	A	MI.19575	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	164	55	M	K	aTg/aAg	0.18	0	0	benign	0.07	neutral	0.35	neutral	3.76	neutral	0.02	deleterious	-3.84	medium_impact	1.98	0.76	neutral	0.62	neutral	2.10	16.86	deleterious	0.31	0.45	0.7	disease	0.74	disease	0.7	disease	0.77	disease	5	0.61	neutral	0.64	deleterious	-3	neutral	0.49	deleterious	0.32	medium_impact	0.08	medium_impact	0.61	medium_impact	0.53	0.8	17.25	12.35	0.28	N	0.84	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12500	12500	T	C	MI.19576	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	164	55	M	T	aTg/aCg	0.18	0	0	benign	0	neutral	0.47	neutral	3.79	neutral	0.34	neutral	-2.27	low_impact	1.28	0.86	neutral	0.9	neutral	0.82	9.59	deleterious	0.58	0.65	0.3	neutral	0.45	neutral	0.39	neutral	0.46	neutral	1	0.53	neutral	0.74	deleterious	-6	neutral	0.25	neutral	2.1	high_impact	0.2	medium_impact	-0.03	medium_impact	0.31	0.8	17.25	12.35	0.34	N	0.42	polymorphism	1	0.04	.	.	.	.	.	.	COSM1155521	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12501	12501	G	C	MI.19577	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	165	55	M	I	atG/atC	2.25	0.04	0.07	benign	0	neutral	0.53	neutral	3.89	neutral	0.94	neutral	1.2	neutral_impact	-0.61	0.84	neutral	0.98	neutral	-0.77	0.05	neutral	0.64	0.7	0.24	neutral	0.21	neutral	0.27	neutral	0.35	neutral	3	0.47	neutral	0.77	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.26	medium_impact	-1.76	low_impact	0.62	0.8	17.25	12.35	0.34	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12501	12501	G	T	MI.19578	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	165	55	M	I	atG/atT	2.25	0.04	0.07	benign	0	neutral	0.53	neutral	3.89	neutral	0.94	neutral	1.2	neutral_impact	-0.61	0.84	neutral	0.98	neutral	-0.64	0.10	neutral	0.64	0.7	0.24	neutral	0.21	neutral	0.27	neutral	0.35	neutral	3	0.47	neutral	0.77	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.26	medium_impact	-1.76	low_impact	0.62	0.8	17.25	12.35	0.34	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12502	12502	T	C	MI.19579	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	166	56	C	R	Tgc/Cgc	-11.74	0	0	benign	0.2	neutral	0.17	neutral	3.8	neutral	0.69	neutral	0.78	low_impact	1.61	0.72	neutral	0.67	neutral	1.82	15.07	deleterious	0.33	0.5	0.27	neutral	0.7	disease	0.52	disease	0.59	disease	2	0.8	neutral	0.49	deleterious	-6	neutral	0.74	deleterious	-0.17	medium_impact	-0.15	medium_impact	0.27	medium_impact	0.33	0.8	26.53	19.85	0.39	N	0.44	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5940	5940	A	G	MI.1958	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	37	13	K	E	Aaa/Gaa	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	-0.88	deleterious	-4.57	neutral	-0.75	high_impact	4.45	0.63	neutral	0.14	damaging	3.58	23.20	deleterious	0.36	0.55	0.64	disease	0.88	disease	0.63	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.71	0.9	3.31	6.65	0.45	N	0.75	polymorphism	0.94	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12502	12502	T	G	MI.19580	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	166	56	C	G	Tgc/Ggc	-11.74	0	0	benign	0.07	neutral	0.19	neutral	3.8	neutral	1.07	neutral	-0.1	low_impact	1.26	0.78	neutral	0.76	neutral	1.63	14.00	neutral	0.31	0.45	0.41	neutral	0.45	neutral	0.42	neutral	0.49	neutral	0	0.79	neutral	0.56	deleterious	-6	neutral	0.70	deleterious	0.32	medium_impact	-0.12	medium_impact	-0.05	medium_impact	0.40	0.8	26.53	19.85	0.38	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12502	12502	T	A	MI.19581	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	166	56	C	S	Tgc/Agc	-11.74	0	0	benign	0	neutral	0.38	neutral	3.87	neutral	1.79	neutral	1.23	neutral_impact	-0.09	0.88	neutral	0.98	neutral	1.63	13.99	neutral	0.46	0.55	0.31	neutral	0.25	neutral	0.24	neutral	0.43	neutral	1	0.62	neutral	0.69	deleterious	-6	neutral	0.67	deleterious	2.1	high_impact	0.12	medium_impact	-1.29	low_impact	0.50	0.8	26.53	19.85	0.37	N	0.39	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12503	12503	G	A	MI.19582	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	167	56	C	Y	tGc/tAc	-5.55	0	0	benign	0	neutral	0.44	neutral	3.81	neutral	1.12	neutral	3.24	neutral_impact	0.11	0.87	neutral	0.98	neutral	0.67	8.65	deleterious	0.38	0.5	0.5	neutral	0.35	neutral	0.24	neutral	0.39	neutral	2	0.56	neutral	0.72	deleterious	-6	neutral	0.72	deleterious	2.1	high_impact	0.18	medium_impact	-1.1	low_impact	0.71	0.85	26.53	19.85	0.3	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12503	12503	G	C	MI.19583	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	167	56	C	S	tGc/tCc	-5.55	0	0	benign	0	neutral	0.38	neutral	3.87	neutral	1.79	neutral	1.23	neutral_impact	-0.09	0.88	neutral	0.98	neutral	1.31	12.30	neutral	0.46	0.55	0.31	neutral	0.25	neutral	0.24	neutral	0.43	neutral	1	0.62	neutral	0.69	deleterious	-6	neutral	0.67	deleterious	2.1	high_impact	0.12	medium_impact	-1.29	low_impact	0.50	0.8	26.53	19.85	0.35	N	0.39	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12503	12503	G	T	MI.19584	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	167	56	C	F	tGc/tTc	-5.55	0	0	benign	0	neutral	0.58	neutral	3.82	neutral	1.26	neutral	1.71	neutral_impact	0.2	0.88	neutral	0.89	neutral	1.70	14.39	neutral	0.36	0.5	0.54	disease	0.5	neutral	0.23	neutral	0.45	neutral	1	0.42	neutral	0.79	deleterious	-6	neutral	0.74	deleterious	2.1	high_impact	0.31	medium_impact	-1.02	low_impact	0.59	0.8	26.53	19.85	0.26	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12504	12504	C	A	MI.19585	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	168	56	C	W	tgC/tgA	-0.27	0	0	possibly_damaging	0.57	neutral	0.1	neutral	3.77	neutral	-1.21	neutral	0.9	low_impact	1.61	0.81	neutral	0.62	neutral	3.19	22.70	deleterious	0.29	0.45	0.27	neutral	0.64	disease	0.29	neutral	0.47	neutral	1	0.9	neutral	0.27	neutral	-3	neutral	0.70	deleterious	-0.86	medium_impact	-0.29	medium_impact	0.27	medium_impact	0.36	0.8	26.53	19.85	0.37	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12504	12504	C	G	MI.19586	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	168	56	C	W	tgC/tgG	-0.27	0	0	possibly_damaging	0.57	neutral	0.1	neutral	3.77	neutral	-1.21	neutral	0.9	low_impact	1.61	0.81	neutral	0.62	neutral	2.87	21.70	deleterious	0.29	0.45	0.27	neutral	0.64	disease	0.29	neutral	0.47	neutral	1	0.9	neutral	0.27	neutral	-3	neutral	0.70	deleterious	-0.86	medium_impact	-0.29	medium_impact	0.27	medium_impact	0.36	0.8	26.53	19.85	0.37	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12505	12505	C	G	MI.19587	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	169	57	L	V	Cta/Gta	-2.11	0	0	benign	0.08	neutral	0.58	neutral	3.69	neutral	-0.85	neutral	-0.38	low_impact	1.79	0.81	neutral	0.71	neutral	1.31	12.33	neutral	0.49	0.55	0.23	neutral	0.33	neutral	0.35	neutral	0.45	neutral	1	0.34	neutral	0.75	deleterious	-6	neutral	0.25	neutral	0.26	medium_impact	0.31	medium_impact	0.43	medium_impact	0.56	0.8	25.37	14.1	0.3	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12505	12505	C	A	MI.19588	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	169	57	L	M	Cta/Ata	-2.11	0	0	benign	0.05	neutral	0.3	neutral	3.64	neutral	-1.74	neutral	0.39	low_impact	1.59	0.87	neutral	0.84	neutral	2.21	17.59	deleterious	0.31	0.45	0.37	neutral	0.24	neutral	0.22	neutral	0.46	neutral	1	0.67	neutral	0.63	deleterious	-6	neutral	0.57	deleterious	0.47	medium_impact	0.03	medium_impact	0.25	medium_impact	0.62	0.8	25.37	14.1	0.44	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12506	12506	T	A	MI.19589	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	170	57	L	Q	cTa/cAa	-3.26	0	0	benign	0.02	neutral	0.32	neutral	3.65	neutral	-1.89	neutral	0.38	neutral_impact	0.64	0.77	neutral	0.86	neutral	1.24	11.96	neutral	0.25	0.45	0.6	disease	0.23	neutral	0.16	neutral	0.55	disease	1	0.67	neutral	0.65	deleterious	-6	neutral	0.61	deleterious	0.86	medium_impact	0.05	medium_impact	-0.62	medium_impact	0.55	0.8	25.37	14.1	0.46	N	0.29	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5941	5941	A	C	MI.1959	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	38	13	K	T	aAa/aCa	6.83	1	0	probably_damaging	1	deleterious	0	neutral	-0.89	deleterious	-4.8	neutral	-1.12	high_impact	4.45	0.67	neutral	0.12	damaging	3.50	23.10	deleterious	0.24	0.55	0.74	disease	0.84	disease	0.62	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.47	0.9	3.31	6.65	0.53	P	0.76	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12506	12506	T	C	MI.19590	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	170	57	L	P	cTa/cCa	-3.26	0	0	benign	0.41	neutral	0.21	neutral	3.59	deleterious	-3.22	neutral	-0.56	medium_impact	2.14	0.65	neutral	0.4	neutral	3.34	22.90	deleterious	0.21	0.45	0.76	disease	0.79	disease	0.54	disease	0.79	disease	6	0.76	neutral	0.4	neutral	-3	neutral	0.72	deleterious	-0.6	medium_impact	-0.09	medium_impact	0.75	medium_impact	0.35	0.8	25.37	14.1	0.32	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12506	12506	T	G	MI.19591	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	170	57	L	R	cTa/cGa	-3.26	0	0	benign	0.2	neutral	0.34	neutral	3.62	neutral	-2.18	neutral	-0.3	low_impact	1.79	0.69	neutral	0.53	neutral	2.48	19.34	deleterious	0.26	0.45	0.68	disease	0.79	disease	0.52	disease	0.74	disease	5	0.59	neutral	0.57	deleterious	-6	neutral	0.67	deleterious	-0.17	medium_impact	0.07	medium_impact	0.43	medium_impact	0.57	0.8	25.37	14.1	0.32	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12508	12508	G	A	MI.19592	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	172	58	D	N	Gac/Aac	-6.47	0	0	benign	0.01	neutral	0.34	neutral	3.77	neutral	-0.48	neutral	2.22	neutral_impact	0.28	0.9	neutral	0.98	neutral	0.65	8.49	deleterious	0.74	0.75	0.33	neutral	0.36	neutral	0.32	neutral	0.45	neutral	1	0.65	neutral	0.67	deleterious	-6	neutral	0.18	neutral	1.15	medium_impact	0.07	medium_impact	-0.95	medium_impact	0.49	0.8	17.74	12.53	0.39	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	COSM1169173	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12508	12508	G	C	MI.19593	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	172	58	D	H	Gac/Cac	-6.47	0	0	possibly_damaging	0.63	neutral	0.52	neutral	3.68	neutral	-2.29	neutral	-0.93	low_impact	1.84	0.78	neutral	0.72	neutral	3.13	22.60	deleterious	0.39	0.5	0.56	disease	0.55	disease	0.66	disease	0.72	disease	4	0.6	neutral	0.45	neutral	-3	neutral	0.64	deleterious	-0.97	medium_impact	0.25	medium_impact	0.48	medium_impact	0.46	0.8	17.74	12.53	0.26	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12508	12508	G	T	MI.19594	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	172	58	D	Y	Gac/Tac	-6.47	0	0	possibly_damaging	0.78	neutral	1	neutral	3.66	neutral	-2.93	deleterious	-2.84	low_impact	1.5	0.84	neutral	0.66	neutral	3.54	23.10	deleterious	0.27	0.45	0.65	disease	0.75	disease	0.66	disease	0.74	disease	5	0.78	neutral	0.61	deleterious	-3	neutral	0.75	deleterious	-1.27	low_impact	1.89	high_impact	0.17	medium_impact	0.27	0.8	17.74	12.53	0.17	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12509	12509	A	G	MI.19595	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	173	58	D	G	gAc/gGc	-0.04	0	0	benign	0	neutral	0.35	neutral	3.77	neutral	-0.71	neutral	2.29	neutral_impact	-0.88	0.84	neutral	0.99	neutral	-0.91	0.03	neutral	0.32	0.5	0.3	neutral	0.14	neutral	0.35	neutral	0.23	neutral	5	0.65	neutral	0.68	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.08	medium_impact	-2.01	low_impact	0.35	0.8	17.74	12.53	0.39	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12509	12509	A	T	MI.19596	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	173	58	D	V	gAc/gTc	-0.04	0	0	benign	0.43	neutral	0.53	neutral	3.68	neutral	-2.36	deleterious	-3.26	low_impact	1.84	0.77	neutral	0.67	neutral	3.22	22.70	deleterious	0.29	0.45	0.48	neutral	0.71	disease	0.61	disease	0.72	disease	4	0.43	neutral	0.55	deleterious	-6	neutral	0.64	deleterious	-0.63	medium_impact	0.26	medium_impact	0.48	medium_impact	0.25	0.8	17.74	12.53	0.23	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12509	12509	A	C	MI.19597	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	173	58	D	A	gAc/gCc	-0.04	0	0	benign	0.12	neutral	0.47	neutral	3.74	neutral	-0.61	neutral	-1.34	low_impact	1.84	0.77	neutral	0.79	neutral	1.61	13.90	neutral	0.34	0.5	0.34	neutral	0.56	disease	0.63	disease	0.72	disease	4	0.45	neutral	0.68	deleterious	-6	neutral	0.31	neutral	0.08	medium_impact	0.2	medium_impact	0.48	medium_impact	0.32	0.8	17.74	12.53	0.31	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12510	12510	C	A	MI.19598	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	174	58	D	E	gaC/gaA	-0.27	0	0	benign	0.01	neutral	0.27	neutral	3.79	neutral	-0.26	neutral	-1	low_impact	1.5	0.83	neutral	0.78	neutral	2.15	17.19	deleterious	0.49	0.55	0.3	neutral	0.54	disease	0.45	neutral	0.46	neutral	1	0.73	neutral	0.63	deleterious	-6	neutral	0.36	neutral	1.15	medium_impact	-0.01	medium_impact	0.17	medium_impact	0.40	0.8	17.74	12.53	0.39	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12510	12510	C	G	MI.19599	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	174	58	D	E	gaC/gaG	-0.27	0	0	benign	0.01	neutral	0.27	neutral	3.79	neutral	-0.26	neutral	-1	low_impact	1.5	0.83	neutral	0.78	neutral	1.85	15.27	deleterious	0.49	0.55	0.3	neutral	0.54	disease	0.45	neutral	0.46	neutral	1	0.73	neutral	0.63	deleterious	-6	neutral	0.36	neutral	1.15	medium_impact	-0.01	medium_impact	0.17	medium_impact	0.40	0.8	17.74	12.53	0.39	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8618	8618	T	A	MI.196	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	92	31	I	N	aTc/aAc	-0.33	0	0.01	possibly_damaging	0.56	deleterious	0.02	neutral	4.29	neutral	-2.52	deleterious	-3.4	medium_impact	2.17	0.83	neutral	0.44	neutral	3.92	23.50	deleterious	0.38	0.65	0.54	disease	0.69	disease	0.26	neutral	0.53	disease	1	0.98	neutral	0.23	neutral	4	deleterious	0.58	deleterious	-0.86	medium_impact	-0.66	medium_impact	0.76	medium_impact	0.42	0.9	28.32	22.32	0.35	N	0.62	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5941	5941	A	T	MI.1960	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	38	13	K	M	aAa/aTa	6.83	1	0	probably_damaging	1	deleterious	0	neutral	-0.9	deleterious	-6.86	neutral	-1.12	high_impact	4.8	0.68	neutral	0.13	damaging	3.79	23.40	deleterious	0.25	0.55	0.89	disease	0.85	disease	0.64	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.33	high_impact	0.58	0.9	3.31	6.65	0.7	P	0.89	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12511	12511	C	A	MI.19600	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	175	59	Q	K	Caa/Aaa	-7.38	0	0	probably_damaging	0.99	neutral	0.29	neutral	3.78	neutral	-0.24	deleterious	-2.74	medium_impact	2.35	0.86	neutral	0.73	neutral	2.53	19.64	deleterious	0.43	0.55	0.53	disease	0.59	disease	0.36	neutral	0.51	disease	0	0.99	deleterious	0.15	neutral	1	deleterious	0.72	deleterious	-2.64	low_impact	0.02	medium_impact	0.94	medium_impact	0.47	0.8	19.24	14.87	0.32	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12511	12511	C	G	MI.19601	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	175	59	Q	E	Caa/Gaa	-7.38	0	0	probably_damaging	0.98	neutral	0.27	neutral	3.78	neutral	-0.24	neutral	-2.01	medium_impact	2.35	0.86	neutral	0.52	neutral	1.56	13.65	neutral	0.4	0.5	0.38	neutral	0.54	disease	0.34	neutral	0.51	disease	0	0.99	deleterious	0.15	neutral	1	deleterious	0.67	deleterious	-2.35	low_impact	-0.01	medium_impact	0.94	medium_impact	0.50	0.8	19.24	14.87	0.33	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12512	12512	A	G	MI.19602	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	176	59	Q	R	cAa/cGa	-1.42	0	0	probably_damaging	0.99	neutral	0.35	neutral	3.73	neutral	-0.86	deleterious	-2.74	medium_impact	2.9	0.76	neutral	0.52	neutral	1.96	15.97	deleterious	0.51	0.6	0.59	disease	0.61	disease	0.42	neutral	0.51	disease	0	0.99	deleterious	0.18	neutral	1	deleterious	0.76	deleterious	-2.64	low_impact	0.08	medium_impact	1.45	medium_impact	0.28	0.8	19.24	14.87	0.33	N	0.42	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12512	12512	A	C	MI.19603	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	176	59	Q	P	cAa/cCa	-1.42	0	0	probably_damaging	1	neutral	0.2	neutral	3.69	neutral	-1.99	deleterious	-4.5	medium_impact	2.1	0.81	neutral	0.62	neutral	1.99	16.13	deleterious	0.16	0.45	0.72	disease	0.78	disease	0.44	neutral	0.63	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.1	medium_impact	0.72	medium_impact	0.31	0.8	19.24	14.87	0.29	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12512	12512	A	T	MI.19604	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	176	59	Q	L	cAa/cTa	-1.42	0	0	probably_damaging	0.99	neutral	0.65	neutral	3.72	neutral	-1.87	deleterious	-5.3	low_impact	1.86	0.84	neutral	0.7	neutral	1.85	15.29	deleterious	0.27	0.45	0.23	neutral	0.5	disease	0.22	neutral	0.43	neutral	1	0.99	deleterious	0.33	neutral	-2	neutral	0.65	deleterious	-2.64	low_impact	0.38	medium_impact	0.5	medium_impact	0.17	0.8	19.24	14.87	0.26	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12513	12513	A	T	MI.19605	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	177	59	Q	H	caA/caT	-0.27	0	0	probably_damaging	1	neutral	0.54	neutral	3.69	neutral	-1.61	deleterious	-2.58	medium_impact	2	0.85	neutral	0.86	neutral	1.82	15.13	deleterious	0.42	0.55	0.7	disease	0.46	neutral	0.25	neutral	0.63	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.27	medium_impact	0.62	medium_impact	0.42	0.8	19.24	14.87	0.26	N	0.40	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12513	12513	A	C	MI.19606	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	177	59	Q	H	caA/caC	-0.27	0	0	probably_damaging	1	neutral	0.54	neutral	3.69	neutral	-1.61	deleterious	-2.58	medium_impact	2	0.85	neutral	0.86	neutral	1.70	14.40	neutral	0.42	0.55	0.7	disease	0.46	neutral	0.25	neutral	0.63	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.27	medium_impact	0.62	medium_impact	0.42	0.8	19.24	14.87	0.26	N	0.40	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12514	12514	G	A	MI.19607	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	178	60	E	K	Gaa/Aaa	-0.73	0	0	possibly_damaging	0.61	neutral	0.35	neutral	3.7	neutral	-0.9	deleterious	-3.74	medium_impact	3.21	0.61	neutral	0.45	neutral	4.33	24.00	deleterious	0.29	0.45	0.84	disease	0.88	disease	0.75	disease	0.84	disease	7	0.68	neutral	0.37	neutral	0	NA	0.88	deleterious	-0.93	medium_impact	0.08	medium_impact	1.73	medium_impact	0.44	0.8	5.31	10.22	0.35	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12514	12514	G	C	MI.19608	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	178	60	E	Q	Gaa/Caa	-0.73	0	0	possibly_damaging	0.83	neutral	0.33	neutral	3.67	neutral	-1.16	deleterious	-2.76	medium_impact	2.52	0.62	neutral	0.58	neutral	3.21	22.70	deleterious	0.46	0.55	0.86	disease	0.69	disease	0.36	neutral	0.63	disease	3	0.85	neutral	0.25	neutral	0	NA	0.84	deleterious	-1.4	low_impact	0.06	medium_impact	1.1	medium_impact	0.69	0.85	5.31	10.22	0.31	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12515	12515	A	G	MI.19609	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	179	60	E	G	gAa/gGa	6.84	1	0	possibly_damaging	0.61	neutral	0.38	neutral	3.63	neutral	-1.89	deleterious	-6.13	medium_impact	3.21	0.65	neutral	0.55	neutral	3.98	23.60	deleterious	0.35	0.5	0.86	disease	0.8	disease	0.75	disease	0.82	disease	6	0.66	neutral	0.39	neutral	0	NA	0.86	deleterious	-0.93	medium_impact	0.12	medium_impact	1.73	medium_impact	0.50	0.8	5.31	10.22	0.59	P	0.52	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5942	5942	A	C	MI.1961	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	39	13	K	N	aaA/aaC	8.69	1	0	probably_damaging	1	deleterious	0	neutral	-0.89	deleterious	-5.08	neutral	-0.94	high_impact	4.45	0.61	neutral	0.12	damaging	3.64	23.20	deleterious	0.49	0.55	0.72	disease	0.87	disease	0.64	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.63	0.9	3.31	6.65	0.53	P	0.76	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12515	12515	A	T	MI.19610	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	179	60	E	V	gAa/gTa	6.84	1	0	possibly_damaging	0.89	neutral	0.53	neutral	3.62	neutral	-2.58	deleterious	-6.5	medium_impact	3.21	0.67	neutral	0.49	neutral	3.85	23.40	deleterious	0.27	0.45	0.92	disease	0.86	disease	0.71	disease	0.81	disease	6	0.88	neutral	0.32	neutral	0	NA	0.87	deleterious	-1.61	low_impact	0.26	medium_impact	1.73	medium_impact	0.63	0.8	5.31	10.22	0.56	P	0.82	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12515	12515	A	C	MI.19611	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	179	60	E	A	gAa/gCa	6.84	1	0	possibly_damaging	0.68	neutral	0.54	neutral	3.67	neutral	-1.23	deleterious	-5.51	medium_impact	3.21	0.69	neutral	0.51	neutral	3.36	22.90	deleterious	0.32	0.5	0.42	neutral	0.76	disease	0.7	disease	0.68	disease	4	0.64	neutral	0.43	neutral	0	NA	0.77	deleterious	-1.06	low_impact	0.27	medium_impact	1.73	medium_impact	0.63	0.8	5.31	10.22	0.52	P	0.74	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12516	12516	A	T	MI.19612	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	180	60	E	D	gaA/gaT	6.61	1	0	benign	0.02	neutral	0.25	neutral	3.66	neutral	-1.42	neutral	-1.64	medium_impact	2.02	0.78	neutral	0.89	neutral	2.57	19.94	deleterious	0.36	0.5	0.75	disease	0.62	disease	0.35	neutral	0.5	neutral	0	0.74	neutral	0.62	deleterious	-3	neutral	0.80	deleterious	0.86	medium_impact	-0.03	medium_impact	0.64	medium_impact	0.77	0.85	5.31	10.22	0.58	P	0.86	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12516	12516	A	C	MI.19613	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	180	60	E	D	gaA/gaC	6.61	1	0	benign	0.02	neutral	0.25	neutral	3.66	neutral	-1.42	neutral	-1.64	medium_impact	2.02	0.78	neutral	0.89	neutral	2.43	19.02	deleterious	0.36	0.5	0.75	disease	0.62	disease	0.35	neutral	0.5	neutral	0	0.74	neutral	0.62	deleterious	-3	neutral	0.80	deleterious	0.86	medium_impact	-0.03	medium_impact	0.64	medium_impact	0.77	0.85	5.31	10.22	0.57	P	0.86	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12517	12517	G	C	MI.19614	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	181	61	V	L	Gtt/Ctt	-0.27	0	0	benign	0.01	neutral	0.66	neutral	3.75	neutral	-0.71	neutral	-0.34	neutral_impact	0.34	0.83	neutral	0.89	neutral	0.21	4.79	deleterious	0.31	0.5	0.3	neutral	0.43	neutral	0.33	neutral	0.46	neutral	1	0.32	neutral	0.83	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.39	medium_impact	-0.89	medium_impact	0.73	0.85	27.36	15.3	0.3	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12517	12517	G	A	MI.19615	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	181	61	V	I	Gtt/Att	-0.27	0	0	benign	0	neutral	0.4	neutral	3.74	neutral	-0.66	neutral	-0.41	low_impact	1.04	0.83	neutral	0.87	neutral	0.28	5.49	deleterious	0.4	0.5	0.24	neutral	0.31	neutral	0.19	neutral	0.45	neutral	1	0.6	neutral	0.7	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.14	medium_impact	-0.25	medium_impact	0.77	0.85	27.36	15.3	0.5	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12517	12517	G	T	MI.19616	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	181	61	V	F	Gtt/Ttt	-0.27	0	0	benign	0.07	neutral	0.7	neutral	3.65	neutral	-1.75	neutral	-1.58	neutral_impact	0.49	0.8	neutral	0.74	neutral	0.61	8.20	deleterious	0.2	0.45	0.21	neutral	0.7	disease	0.39	neutral	0.55	disease	1	0.21	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.32	medium_impact	0.44	medium_impact	-0.76	medium_impact	0.56	0.8	27.36	15.3	0.22	N	0.21	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12518	12518	T	C	MI.19617	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	182	61	V	A	gTt/gCt	-4.86	0	0	benign	0	neutral	0.51	neutral	3.69	neutral	-1	neutral	0.24	neutral_impact	-0.55	0.86	neutral	0.98	neutral	-0.43	0.33	neutral	0.31	0.45	0.39	neutral	0.27	neutral	0.23	neutral	0.45	neutral	1	0.49	neutral	0.76	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.24	medium_impact	-1.71	low_impact	0.43	0.8	27.36	15.3	0.32	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	COSM1155522	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12518	12518	T	G	MI.19618	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	182	61	V	G	gTt/gGt	-4.86	0	0	benign	0.03	neutral	0.33	neutral	3.62	neutral	-2.52	neutral	-1.98	neutral_impact	0.24	0.8	neutral	0.74	neutral	0.52	7.60	deleterious	0.18	0.45	0.67	disease	0.57	disease	0.45	neutral	0.5	neutral	0	0.65	neutral	0.65	deleterious	-6	neutral	0.23	neutral	0.69	medium_impact	0.06	medium_impact	-0.98	medium_impact	0.55	0.8	27.36	15.3	0.29	N	0.17	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12518	12518	T	A	MI.19619	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	182	61	V	D	gTt/gAt	-4.86	0	0	benign	0.04	neutral	0.21	neutral	3.6	deleterious	-3.03	neutral	-2.36	low_impact	1.04	0.75	neutral	0.59	neutral	2.47	19.29	deleterious	0.12	0.4	0.8	disease	0.74	disease	0.66	disease	0.78	disease	6	0.78	neutral	0.59	deleterious	-6	neutral	0.27	neutral	0.57	medium_impact	-0.09	medium_impact	-0.25	medium_impact	0.50	0.8	27.36	15.3	0.29	N	0.19	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5942	5942	A	T	MI.1962	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	39	13	K	N	aaA/aaT	8.69	1	0	probably_damaging	1	deleterious	0	neutral	-0.89	deleterious	-5.08	neutral	-0.94	high_impact	4.45	0.61	neutral	0.12	damaging	3.72	23.30	deleterious	0.49	0.55	0.72	disease	0.87	disease	0.64	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.63	0.9	3.31	6.65	0.54	P	0.76	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12520	12520	A	G	MI.19620	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	184	62	I	V	Att/Gtt	-5.78	0	0	benign	0.04	neutral	0.5	neutral	1.51	neutral	-0.89	neutral	-0.16	low_impact	1.9	0.89	neutral	0.97	neutral	1.38	12.69	neutral	0.53	0.6	0.43	neutral	0.17	neutral	0.29	neutral	0.29	neutral	4	0.46	neutral	0.73	deleterious	-6	neutral	0.62	deleterious	0.57	medium_impact	0.23	medium_impact	0.53	medium_impact	0.51	0.8	20.23	12.58	0.42	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12520	12520	A	T	MI.19621	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	184	62	I	F	Att/Ttt	-5.78	0	0	possibly_damaging	0.77	neutral	0.7	neutral	1.53	neutral	-0.56	deleterious	-2.63	medium_impact	2.87	0.7	neutral	0.51	neutral	3.60	23.20	deleterious	0.42	0.5	0.65	disease	0.69	disease	0.51	disease	0.54	disease	1	0.72	neutral	0.47	neutral	0	NA	0.77	deleterious	-1.24	low_impact	0.44	medium_impact	1.42	medium_impact	0.81	0.85	20.23	12.58	0.21	N	0.47	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12520	12520	A	C	MI.19622	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	184	62	I	L	Att/Ctt	-5.78	0	0	benign	0.17	neutral	0.65	neutral	1.53	neutral	-0.62	neutral	-0.84	medium_impact	2.12	0.82	neutral	0.94	neutral	2.46	19.23	deleterious	0.37	0.5	0.38	neutral	0.48	neutral	0.32	neutral	0.48	neutral	1	0.23	neutral	0.74	deleterious	-3	neutral	0.65	deleterious	-0.09	medium_impact	0.38	medium_impact	0.73	medium_impact	0.75	0.85	20.23	12.58	0.3	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12521	12521	T	C	MI.19623	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	185	62	I	T	aTt/aCt	-1.88	0	0	benign	0.07	neutral	0.39	neutral	1.55	neutral	-0.39	deleterious	-2.77	low_impact	0.82	0.88	neutral	0.96	neutral	1.79	14.94	neutral	0.39	0.5	0.58	disease	0.38	neutral	0.33	neutral	0.62	disease	2	0.57	neutral	0.66	deleterious	-6	neutral	0.72	deleterious	0.32	medium_impact	0.13	medium_impact	-0.45	medium_impact	0.63	0.8	20.23	12.58	0.32	N	0.14	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12521	12521	T	G	MI.19624	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	185	62	I	S	aTt/aGt	-1.88	0	0	possibly_damaging	0.57	neutral	0.41	neutral	1.52	neutral	-0.69	deleterious	-3.9	medium_impact	2.17	0.79	neutral	0.72	neutral	4.04	23.70	deleterious	0.27	0.45	0.48	neutral	0.7	disease	0.42	neutral	0.53	disease	1	0.62	neutral	0.42	neutral	0	NA	0.75	deleterious	-0.86	medium_impact	0.15	medium_impact	0.78	medium_impact	0.52	0.8	20.23	12.58	0.27	N	0.56	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12521	12521	T	A	MI.19625	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	185	62	I	N	aTt/aAt	-1.88	0	0	possibly_damaging	0.77	neutral	0.31	neutral	1.47	neutral	-1.5	deleterious	-4.86	medium_impact	2.87	0.66	neutral	0.44	neutral	4.15	23.80	deleterious	0.25	0.45	0.25	neutral	0.78	disease	0.63	disease	0.74	disease	5	0.81	neutral	0.27	neutral	0	NA	0.70	deleterious	-1.24	low_impact	0.04	medium_impact	1.42	medium_impact	0.54	0.8	20.23	12.58	0.33	N	0.79	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12522	12522	T	G	MI.19626	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	186	62	I	M	atT/atG	0.41	0	0	benign	0.12	neutral	0.22	neutral	1.48	neutral	-1.37	neutral	-0.68	low_impact	1.25	0.84	neutral	0.96	neutral	1.90	15.60	deleterious	0.48	0.55	0.26	neutral	0.37	neutral	0.3	neutral	0.46	neutral	1	0.75	neutral	0.55	deleterious	-6	neutral	0.65	deleterious	0.08	medium_impact	-0.07	medium_impact	-0.06	medium_impact	0.80	0.85	20.23	12.58	0.44	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12522	12522	T	A	MI.19627	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	186	62	I	M	atT/atA	0.41	0	0	benign	0.12	neutral	0.22	neutral	1.48	neutral	-1.37	neutral	-0.68	low_impact	1.25	0.84	neutral	0.96	neutral	2.22	17.67	deleterious	0.48	0.55	0.26	neutral	0.37	neutral	0.3	neutral	0.46	neutral	1	0.75	neutral	0.55	deleterious	-6	neutral	0.65	deleterious	0.08	medium_impact	-0.07	medium_impact	-0.06	medium_impact	0.80	0.85	20.23	12.58	0.45	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12523	12523	A	C	MI.19628	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	187	63	I	L	Atc/Ctc	-6.7	0	0	benign	0.22	neutral	0.75	neutral	1.22	neutral	-1.77	neutral	-1.72	low_impact	1.83	0.82	neutral	0.9	neutral	0.77	9.27	deleterious	0.39	0.5	0.32	neutral	0.36	neutral	0.3	neutral	0.46	neutral	1	0.16	neutral	0.77	deleterious	-6	neutral	0.23	neutral	-0.22	medium_impact	0.5	medium_impact	0.47	medium_impact	0.68	0.85	3.32	8.29	0.3	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12523	12523	A	T	MI.19629	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	187	63	I	F	Atc/Ttc	-6.7	0	0	possibly_damaging	0.83	neutral	0.85	neutral	1.15	neutral	-2.54	deleterious	-3.66	medium_impact	2.58	0.79	neutral	0.36	neutral	3.47	23.00	deleterious	0.39	0.5	0.66	disease	0.61	disease	0.64	disease	0.56	disease	1	0.81	neutral	0.51	deleterious	0	NA	0.70	deleterious	-1.4	low_impact	0.65	medium_impact	1.15	medium_impact	0.64	0.8	3.32	8.29	0.17	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5943	5943	G	C	MI.1963	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	40	14	D	H	Gac/Cac	2.67	1	0	probably_damaging	1	deleterious	0.03	neutral	-1.24	neutral	-1.99	neutral	-1.34	high_impact	3.99	0.59	damaging	0.06	damaging	3.43	23.00	deleterious	0.33	0.55	0.48	neutral	0.9	disease	0.61	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-0.65	medium_impact	2.59	high_impact	0.63	0.9	1.56	6.7	0.37	N	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12523	12523	A	G	MI.19630	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	187	63	I	V	Atc/Gtc	-6.7	0	0	benign	0.04	neutral	0.6	neutral	1.18	neutral	-2.17	neutral	-0.6	low_impact	1.25	0.87	neutral	0.93	neutral	-0.43	0.32	neutral	0.54	0.6	0.26	neutral	0.12	neutral	0.31	neutral	0.3	neutral	4	0.35	neutral	0.78	deleterious	-6	neutral	0.10	neutral	0.57	medium_impact	0.33	medium_impact	-0.06	medium_impact	0.57	0.8	3.32	8.29	0.38	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12524	12524	T	C	MI.19631	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	188	63	I	T	aTc/aCc	-0.27	0	0	benign	0.1	neutral	0.44	neutral	1.13	neutral	-2.8	deleterious	-3.94	low_impact	1.2	0.85	neutral	0.92	neutral	1.39	12.73	neutral	0.32	0.5	0.45	neutral	0.24	neutral	0.31	neutral	0.45	neutral	1	0.5	neutral	0.67	deleterious	-6	neutral	0.53	deleterious	0.16	medium_impact	0.18	medium_impact	-0.11	medium_impact	0.63	0.8	3.32	8.29	0.4	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12524	12524	T	A	MI.19632	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	188	63	I	N	aTc/aAc	-0.27	0	0	probably_damaging	0.9	neutral	0.35	neutral	1.06	deleterious	-4.97	deleterious	-6.18	medium_impact	2.45	0.74	neutral	0.52	neutral	4.19	23.90	deleterious	0.25	0.45	0.85	disease	0.73	disease	0.66	disease	0.76	disease	5	0.91	neutral	0.23	neutral	1	deleterious	0.79	deleterious	-1.65	low_impact	0.08	medium_impact	1.04	medium_impact	0.45	0.8	3.32	8.29	0.27	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12524	12524	T	G	MI.19633	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	188	63	I	S	aTc/aGc	-0.27	0	0	possibly_damaging	0.56	neutral	0.51	neutral	1.08	deleterious	-3.81	deleterious	-5.19	low_impact	1.75	0.75	neutral	0.73	neutral	2.80	21.40	deleterious	0.26	0.45	0.73	disease	0.63	disease	0.42	neutral	0.54	disease	1	0.54	neutral	0.48	deleterious	-3	neutral	0.71	deleterious	-0.85	medium_impact	0.24	medium_impact	0.4	medium_impact	0.52	0.8	3.32	8.29	0.29	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12525	12525	C	G	MI.19634	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	189	63	I	M	atC/atG	1.1	0	0	benign	0.16	neutral	0.28	neutral	1.08	deleterious	-3.91	neutral	-2.44	medium_impact	1.94	0.84	neutral	0.79	neutral	2.03	16.39	deleterious	0.4	0.5	0.37	neutral	0.3	neutral	0.3	neutral	0.47	neutral	1	0.67	neutral	0.56	deleterious	-3	neutral	0.62	deleterious	-0.06	medium_impact	0.01	medium_impact	0.57	medium_impact	0.70	0.85	3.32	8.29	0.45	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12525	12525	C	A	MI.19635	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	189	63	I	M	atC/atA	1.1	0	0	benign	0.16	neutral	0.28	neutral	1.08	deleterious	-3.91	neutral	-2.44	medium_impact	1.94	0.84	neutral	0.79	neutral	2.42	18.98	deleterious	0.4	0.5	0.37	neutral	0.3	neutral	0.3	neutral	0.47	neutral	1	0.67	neutral	0.56	deleterious	-3	neutral	0.62	deleterious	-0.06	medium_impact	0.01	medium_impact	0.57	medium_impact	0.70	0.85	3.32	8.29	0.45	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12526	12526	T	G	MI.19636	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	190	64	S	A	Tcg/Gcg	-9.22	0	0	possibly_damaging	0.44	neutral	0.61	neutral	1.53	neutral	-0.8	neutral	-2.49	low_impact	1.4	0.79	neutral	0.65	neutral	1.87	15.41	deleterious	0.42	0.5	0.47	neutral	0.37	neutral	0.59	disease	0.49	neutral	0	0.38	neutral	0.59	deleterious	-3	neutral	0.35	neutral	-0.65	medium_impact	0.34	medium_impact	0.08	medium_impact	0.73	0.85	25.54	16.09	0.26	N	0.28	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12526	12526	T	C	MI.19637	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	190	64	S	P	Tcg/Ccg	-9.22	0	0	probably_damaging	0.9	neutral	0.23	neutral	1.56	neutral	-0.35	deleterious	-4.34	medium_impact	3.1	0.5	damaging	0.37	neutral	3.71	23.30	deleterious	0.18	0.45	0.74	disease	0.82	disease	0.57	disease	0.77	disease	5	0.93	neutral	0.17	neutral	1	deleterious	0.79	deleterious	-1.65	low_impact	-0.06	medium_impact	1.63	medium_impact	0.63	0.8	25.54	16.09	0.35	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12526	12526	T	A	MI.19638	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	190	64	S	T	Tcg/Acg	-9.22	0	0	benign	0.06	neutral	0.75	neutral	1.64	neutral	0.57	neutral	-1.96	neutral_impact	-0.44	0.8	neutral	0.93	neutral	-1.04	0.01	neutral	0.37	0.5	0.33	neutral	0.07	neutral	0.18	neutral	0.25	neutral	5	0.16	neutral	0.85	deleterious	-6	neutral	0.14	neutral	0.39	medium_impact	0.5	medium_impact	-1.61	low_impact	0.81	0.85	25.54	16.09	0.44	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12527	12527	C	T	MI.19639	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	191	64	S	L	tCg/tTg	-0.04	0	0	possibly_damaging	0.56	neutral	1	neutral	1.54	neutral	-0.64	deleterious	-4.86	low_impact	1.44	0.82	neutral	0.63	neutral	2.89	21.80	deleterious	0.3	0.45	0.2	neutral	0.6	disease	0.37	neutral	0.45	neutral	1	0.56	neutral	0.72	deleterious	-3	neutral	0.46	deleterious	-0.85	medium_impact	1.89	high_impact	0.11	medium_impact	0.87	0.9	25.54	16.09	0.22	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5943	5943	G	A	MI.1964	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	40	14	D	N	Gac/Aac	2.67	1	0	probably_damaging	1	neutral	0.05	neutral	-1.21	neutral	-1.33	neutral	-0.91	medium_impact	2.8	0.52	damaging	0.08	damaging	4.07	23.70	deleterious	0.67	0.7	0.3	neutral	0.85	disease	0.51	disease	0.55	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.78	deleterious	-3.58	low_impact	-0.52	medium_impact	1.49	medium_impact	0.82	0.9	1.56	6.7	0.5	N	0.89	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12527	12527	C	G	MI.19640	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	191	64	S	W	tCg/tGg	-0.04	0	0	benign	0.04	neutral	0.37	neutral	1.46	deleterious	-4.54	deleterious	-5.76	medium_impact	2.42	0.76	neutral	0.48	neutral	4.15	23.80	deleterious	0.19	0.45	0.89	disease	0.82	disease	0.59	disease	0.8	disease	6	0.6	neutral	0.67	deleterious	-3	neutral	0.83	deleterious	0.57	medium_impact	0.11	medium_impact	1.01	medium_impact	0.51	0.8	25.54	16.09	0.26	N	0.21	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12529	12529	A	T	MI.19641	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	193	65	N	Y	Aac/Tac	-9.91	0	0	probably_damaging	0.95	neutral	1	neutral	1.5	neutral	-1.92	deleterious	-7.56	medium_impact	2.98	0.82	neutral	0.58	neutral	3.53	23.10	deleterious	0.44	0.55	0.69	disease	0.55	disease	0.49	neutral	0.51	disease	0	0.95	neutral	0.53	deleterious	1	deleterious	0.76	deleterious	-1.96	low_impact	1.89	high_impact	1.52	medium_impact	0.36	0.8	13.76	11.33	0.22	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12529	12529	A	C	MI.19642	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	193	65	N	H	Aac/Cac	-9.91	0	0	probably_damaging	0.93	neutral	0.54	neutral	1.51	neutral	-1.61	deleterious	-4.69	medium_impact	2.54	0.76	neutral	0.57	neutral	2.87	21.70	deleterious	0.58	0.65	0.52	disease	0.38	neutral	0.55	disease	0.5	neutral	0	0.92	neutral	0.31	neutral	1	deleterious	0.69	deleterious	-1.81	low_impact	0.27	medium_impact	1.12	medium_impact	0.55	0.8	13.76	11.33	0.28	N	0.48	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12529	12529	A	G	MI.19643	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	193	65	N	D	Aac/Gac	-9.91	0	0	possibly_damaging	0.56	neutral	0.21	neutral	1.49	neutral	-2.66	deleterious	-4.74	medium_impact	2.63	0.74	neutral	0.48	neutral	2.10	16.86	deleterious	0.67	0.7	0.6	disease	0.39	neutral	0.74	disease	0.68	disease	4	0.78	neutral	0.33	neutral	0	NA	0.52	deleterious	-0.85	medium_impact	-0.09	medium_impact	1.2	medium_impact	0.54	0.8	13.76	11.33	0.37	N	0.63	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12530	12530	A	T	MI.19644	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	194	65	N	I	aAc/aTc	1.56	0	0	possibly_damaging	0.78	neutral	0.41	neutral	1.61	neutral	0.28	deleterious	-8.52	medium_impact	2.75	0.8	neutral	0.58	neutral	3.70	23.30	deleterious	0.4	0.5	0.52	disease	0.6	disease	0.64	disease	0.65	disease	3	0.78	neutral	0.32	neutral	0	NA	0.70	deleterious	-1.27	low_impact	0.15	medium_impact	1.31	medium_impact	0.30	0.8	13.76	11.33	0.33	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12530	12530	A	C	MI.19645	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	194	65	N	T	aAc/aCc	1.56	0	0	benign	0.06	neutral	0.42	neutral	1.57	neutral	-0.18	deleterious	-5.48	low_impact	1.85	0.84	neutral	0.78	neutral	0.56	7.90	deleterious	0.51	0.6	0.44	neutral	0.3	neutral	0.38	neutral	0.46	neutral	1	0.53	neutral	0.68	deleterious	-6	neutral	0.42	neutral	0.39	medium_impact	0.16	medium_impact	0.49	medium_impact	0.44	0.8	13.76	11.33	0.4	N	0.22	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12530	12530	A	G	MI.19646	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	194	65	N	S	aAc/aGc	1.56	0	0	benign	0.06	neutral	0.44	neutral	1.53	neutral	-1.13	deleterious	-4.66	low_impact	1.51	0.82	neutral	0.56	neutral	-0.09	1.78	neutral	0.62	0.65	0.39	neutral	0.18	neutral	0.41	neutral	0.3	neutral	4	0.51	neutral	0.69	deleterious	-6	neutral	0.18	neutral	0.39	medium_impact	0.18	medium_impact	0.18	medium_impact	0.28	0.8	13.76	11.33	0.42	N	0.06	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12531	12531	C	A	MI.19647	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	195	65	N	K	aaC/aaA	-0.04	0	0	possibly_damaging	0.56	neutral	0.3	neutral	1.51	neutral	-1.63	deleterious	-5.68	medium_impact	2.89	0.73	neutral	0.41	neutral	2.60	20.20	deleterious	0.67	0.7	0.47	neutral	0.48	neutral	0.73	disease	0.61	disease	2	0.7	neutral	0.37	neutral	0	NA	0.55	deleterious	-0.85	medium_impact	0.03	medium_impact	1.44	medium_impact	0.54	0.8	13.76	11.33	0.36	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12531	12531	C	G	MI.19648	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	195	65	N	K	aaC/aaG	-0.04	0	0	possibly_damaging	0.56	neutral	0.3	neutral	1.51	neutral	-1.63	deleterious	-5.68	medium_impact	2.89	0.73	neutral	0.41	neutral	2.24	17.77	deleterious	0.67	0.7	0.47	neutral	0.48	neutral	0.73	disease	0.61	disease	2	0.7	neutral	0.37	neutral	0	NA	0.55	deleterious	-0.85	medium_impact	0.03	medium_impact	1.44	medium_impact	0.54	0.8	13.76	11.33	0.36	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12532	12532	T	C	MI.19649	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	196	66	W	R	Tga/Cga	-0.04	0	0	probably_damaging	0.98	neutral	0.35	neutral	1.35	deleterious	-3.43	deleterious	-13.78	medium_impact	3.5	0.66	neutral	0.36	neutral	3.43	23.00	deleterious	0.34	0.5	0.7	disease	0.8	disease	0.81	disease	0.8	disease	6	0.98	neutral	0.19	neutral	1	deleterious	0.84	deleterious	-2.35	low_impact	0.08	medium_impact	1.99	medium_impact	0.26	0.8	21.89	6.97	0.45	N	0.97	polymorphism	0.93	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5943	5943	G	T	MI.1965	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	40	14	D	Y	Gac/Tac	2.67	1	0	probably_damaging	1	deleterious	0	neutral	-1.24	deleterious	-3.06	neutral	-1.75	high_impact	3.85	0.56	damaging	0.06	damaging	3.73	23.30	deleterious	0.25	0.55	0.61	disease	0.95	disease	0.61	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.46	high_impact	0.35	0.9	1.56	6.7	0.37	N	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12532	12532	T	G	MI.19650	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	196	66	W	G	Tga/Gga	-0.04	0	0	probably_damaging	0.97	neutral	0.33	neutral	1.4	neutral	-1.95	deleterious	-12.8	medium_impact	2.81	0.66	neutral	0.51	neutral	3.75	23.30	deleterious	0.3	0.45	0.71	disease	0.73	disease	0.78	disease	0.76	disease	5	0.97	neutral	0.18	neutral	1	deleterious	0.80	deleterious	-2.18	low_impact	0.06	medium_impact	1.36	medium_impact	0.24	0.8	21.89	6.97	0.41	N	0.97	polymorphism	0.82	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12533	12533	G	T	MI.19651	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	197	66	W	L	tGa/tTa	4.31	1	0	benign	0.17	neutral	0.65	neutral	1.57	neutral	-0.08	deleterious	-12.8	low_impact	1.67	0.7	neutral	0.62	neutral	4.02	23.60	deleterious	0.29	0.45	0.35	neutral	0.58	disease	0.61	disease	0.46	neutral	1	0.23	neutral	0.74	deleterious	-6	neutral	0.73	deleterious	-0.09	medium_impact	0.38	medium_impact	0.32	medium_impact	0.30	0.8	21.89	6.97	0.4	N	0.97	polymorphism	0.63	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12533	12533	G	C	MI.19652	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	197	66	W	S	tGa/tCa	4.31	1	0	probably_damaging	0.98	neutral	0.41	neutral	1.45	neutral	-1.16	deleterious	-13.78	medium_impact	2.69	0.72	neutral	0.62	neutral	3.81	23.40	deleterious	0.27	0.45	0.4	neutral	0.77	disease	0.75	disease	0.64	disease	3	0.98	neutral	0.22	neutral	1	deleterious	0.80	deleterious	-2.35	low_impact	0.15	medium_impact	1.25	medium_impact	0.18	0.8	21.89	6.97	0.42	N	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12534	12534	A	C	MI.19653	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	198	66	W	C	tgA/tgC	2.94	0.99	0	probably_damaging	0.99	neutral	0.18	neutral	1.35	deleterious	-3.95	deleterious	-12.8	medium_impact	3.5	0.64	neutral	0.4	neutral	3.84	23.40	deleterious	0.26	0.45	0.75	disease	0.82	disease	0.74	disease	0.77	disease	5	0.99	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	-0.13	medium_impact	1.99	medium_impact	0.26	0.8	21.89	6.97	0.42	N	0.98	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12534	12534	A	T	MI.19654	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	198	66	W	C	tgA/tgT	2.94	0.99	0	probably_damaging	0.99	neutral	0.18	neutral	1.35	deleterious	-3.95	deleterious	-12.8	medium_impact	3.5	0.64	neutral	0.4	neutral	3.92	23.50	deleterious	0.26	0.45	0.75	disease	0.82	disease	0.74	disease	0.77	disease	5	0.99	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	-0.13	medium_impact	1.99	medium_impact	0.26	0.8	21.89	6.97	0.43	N	0.98	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12535	12535	C	T	MI.19655	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	199	67	H	Y	Cac/Tac	0.41	0.04	0	probably_damaging	0.95	neutral	1	neutral	1.49	neutral	-2.74	deleterious	-5.47	medium_impact	2.08	0.82	neutral	0.52	neutral	3.36	22.90	deleterious	0.63	0.7	0.65	disease	0.47	neutral	0.44	neutral	0.63	disease	3	0.95	neutral	0.53	deleterious	1	deleterious	0.72	deleterious	-1.96	low_impact	1.89	high_impact	0.7	medium_impact	0.43	0.8	15.59	14.68	0.21	N	0.77	polymorphism	1	0.05	rs876661356	Uncertain_significance	not_specified	236824	MedGen:CN169374	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12535	12535	C	A	MI.19656	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	199	67	H	N	Cac/Aac	0.41	0.04	0	probably_damaging	0.95	neutral	0.31	neutral	1.65	neutral	0.71	deleterious	-5.28	low_impact	1.54	0.83	neutral	0.81	neutral	2.27	17.99	deleterious	0.63	0.7	0.58	disease	0.29	neutral	0.4	neutral	0.58	disease	2	0.96	neutral	0.18	neutral	-2	neutral	0.66	deleterious	-1.96	low_impact	0.04	medium_impact	0.2	medium_impact	0.67	0.85	15.59	14.68	0.38	N	0.61	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12535	12535	C	G	MI.19657	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	199	67	H	D	Cac/Gac	0.41	0.04	0	probably_damaging	0.95	neutral	0.2	neutral	1.62	neutral	0.45	deleterious	-7.62	medium_impact	1.96	0.75	neutral	0.41	neutral	3.46	23.00	deleterious	0.29	0.45	0.7	disease	0.47	neutral	0.63	disease	0.66	disease	3	0.97	neutral	0.13	neutral	1	deleterious	0.71	deleterious	-1.96	low_impact	-0.1	medium_impact	0.59	medium_impact	0.55	0.8	15.59	14.68	0.37	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12536	12536	A	G	MI.19658	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	200	67	H	R	cAc/cGc	-0.04	0	0	probably_damaging	0.97	neutral	0.35	neutral	1.6	neutral	0.23	deleterious	-6.9	medium_impact	2.93	0.81	neutral	0.6	neutral	2.44	19.09	deleterious	0.61	0.65	0.62	disease	0.38	neutral	0.56	disease	0.63	disease	3	0.97	neutral	0.19	neutral	1	deleterious	0.70	deleterious	-2.18	low_impact	0.08	medium_impact	1.47	medium_impact	0.43	0.8	15.59	14.68	0.35	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12536	12536	A	T	MI.19659	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	200	67	H	L	cAc/cTc	-0.04	0	0	possibly_damaging	0.83	neutral	0.65	neutral	1.54	neutral	-0.7	deleterious	-9.84	medium_impact	2.73	0.82	neutral	0.48	neutral	1.76	14.77	neutral	0.31	0.45	0.2	neutral	0.52	disease	0.58	disease	0.69	disease	4	0.8	neutral	0.41	neutral	0	NA	0.38	neutral	-1.4	low_impact	0.38	medium_impact	1.29	medium_impact	0.34	0.8	15.59	14.68	0.29	N	0.95	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5944	5944	A	C	MI.1966	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	41	14	D	A	gAc/gCc	9.38	1	0	probably_damaging	1	deleterious	0	neutral	-1.22	neutral	-0.99	neutral	-1.56	high_impact	4.2	0.65	neutral	0.06	damaging	3.45	23.00	deleterious	0.3	0.55	0.28	neutral	0.88	disease	0.62	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.78	high_impact	0.57	0.9	1.56	6.7	0.49	N	0.85	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12536	12536	A	C	MI.19660	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	200	67	H	P	cAc/cCc	-0.04	0	0	probably_damaging	0.98	neutral	0.2	neutral	1.54	neutral	-0.88	deleterious	-8.86	low_impact	1.05	0.72	neutral	0.6	neutral	2.85	21.60	deleterious	0.27	0.45	0.74	disease	0.71	disease	0.59	disease	0.6	disease	2	0.99	deleterious	0.11	neutral	-2	neutral	0.82	deleterious	-2.35	low_impact	-0.1	medium_impact	-0.24	medium_impact	0.41	0.8	15.59	14.68	0.33	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12537	12537	C	A	MI.19661	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	201	67	H	Q	caC/caA	0.18	0	0	probably_damaging	0.98	neutral	0.29	neutral	1.56	neutral	-0.37	deleterious	-6.88	low_impact	1.46	0.84	neutral	0.75	neutral	2.03	16.41	deleterious	0.6	0.65	0.62	disease	0.23	neutral	0.37	neutral	0.57	disease	1	0.98	deleterious	0.16	neutral	-2	neutral	0.70	deleterious	-2.35	low_impact	0.02	medium_impact	0.13	medium_impact	0.57	0.8	15.59	14.68	0.41	N	0.77	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12537	12537	C	G	MI.19662	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	201	67	H	Q	caC/caG	0.18	0	0	probably_damaging	0.98	neutral	0.29	neutral	1.56	neutral	-0.37	deleterious	-6.88	low_impact	1.46	0.84	neutral	0.75	neutral	1.77	14.83	neutral	0.6	0.65	0.62	disease	0.23	neutral	0.37	neutral	0.57	disease	1	0.98	deleterious	0.16	neutral	-2	neutral	0.70	deleterious	-2.35	low_impact	0.02	medium_impact	0.13	medium_impact	0.57	0.8	15.59	14.68	0.4	N	0.77	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12538	12538	T	G	MI.19663	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	202	68	W	G	Tga/Gga	-3.94	0	0	probably_damaging	1	neutral	0.32	neutral	0.44	deleterious	-7.81	deleterious	-12.8	high_impact	4.21	0.55	damaging	0.06	damaging	3.72	23.30	deleterious	0.24	0.45	0.88	disease	0.76	disease	0.81	disease	0.83	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.05	medium_impact	2.64	high_impact	0.31	0.8	25.54	7.33	0.37	N	0.97	polymorphism	0.96	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12538	12538	T	C	MI.19664	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	202	68	W	R	Tga/Cga	-3.94	0	0	probably_damaging	1	neutral	0.34	neutral	0.44	deleterious	-7.43	deleterious	-13.78	high_impact	4.21	0.58	damaging	0.07	damaging	3.43	23.00	deleterious	0.26	0.45	0.84	disease	0.82	disease	0.85	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.07	medium_impact	2.64	high_impact	0.33	0.8	25.54	7.33	0.4	N	0.97	polymorphism	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12539	12539	G	C	MI.19665	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	203	68	W	S	tGa/tCa	2.71	0.99	0	probably_damaging	1	neutral	0.48	neutral	0.44	deleterious	-6.92	deleterious	-13.78	high_impact	3.87	0.57	damaging	0.07	damaging	3.82	23.40	deleterious	0.25	0.45	0.8	disease	0.84	disease	0.79	disease	0.84	disease	7	1	deleterious	0.24	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.21	medium_impact	2.33	high_impact	0.24	0.8	25.54	7.33	0.46	N	0.95	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12539	12539	G	T	MI.19666	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	203	68	W	L	tGa/tTa	2.71	0.99	0	probably_damaging	1	neutral	0.71	neutral	0.61	deleterious	-3.23	deleterious	-12.8	medium_impact	2.24	0.5	damaging	0.09	damaging	4.08	23.70	deleterious	0.27	0.45	0.67	disease	0.62	disease	0.63	disease	0.46	neutral	1	1	deleterious	0.36	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.45	medium_impact	0.84	medium_impact	0.28	0.8	25.54	7.33	0.36	N	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12540	12540	A	T	MI.19667	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	204	68	W	C	tgA/tgT	5.46	1	0	probably_damaging	1	neutral	0.19	neutral	0.44	deleterious	-8.05	deleterious	-12.8	high_impact	4.21	0.55	damaging	0.05	damaging	3.98	23.60	deleterious	0.25	0.45	0.93	disease	0.84	disease	0.77	disease	0.87	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.12	medium_impact	2.64	high_impact	0.30	0.8	25.54	7.33	0.48	N	0.98	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12540	12540	A	C	MI.19668	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	204	68	W	C	tgA/tgC	5.46	1	0	probably_damaging	1	neutral	0.19	neutral	0.44	deleterious	-8.05	deleterious	-12.8	high_impact	4.21	0.55	damaging	0.05	damaging	3.88	23.50	deleterious	0.25	0.45	0.93	disease	0.84	disease	0.77	disease	0.87	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.12	medium_impact	2.64	high_impact	0.30	0.8	25.54	7.33	0.48	N	0.98	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12541	12541	G	T	MI.19669	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	205	69	A	S	Gcc/Tcc	2.25	0.95	0	benign	0.27	neutral	0.53	neutral	1.53	neutral	-1.12	neutral	-0.61	neutral_impact	0.18	0.79	neutral	0.76	neutral	1.74	14.63	neutral	0.47	0.55	0.5	disease	0.2	neutral	0.19	neutral	0.19	neutral	6	0.37	neutral	0.63	deleterious	-6	neutral	0.30	neutral	-0.34	medium_impact	0.26	medium_impact	-1.04	low_impact	0.89	0.9	28.03	15.07	0.4	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5944	5944	A	T	MI.1967	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	41	14	D	V	gAc/gTc	9.38	1	0	probably_damaging	1	deleterious	0.04	neutral	-1.24	neutral	-1.41	neutral	-1.76	medium_impact	2.8	0.58	damaging	0.06	damaging	3.50	23.10	deleterious	0.27	0.55	0.3	neutral	0.93	disease	0.64	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-0.58	medium_impact	1.49	medium_impact	0.38	0.9	1.56	6.7	0.43	N	0.93	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12541	12541	G	A	MI.19670	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	205	69	A	T	Gcc/Acc	2.25	0.95	0	benign	0.01	neutral	0.65	neutral	1.55	neutral	-0.74	neutral	0.1	neutral_impact	-0.9	0.89	neutral	0.94	neutral	0.82	9.59	deleterious	0.49	0.55	0.45	neutral	0.14	neutral	0.18	neutral	0.31	neutral	4	0.33	neutral	0.82	deleterious	-6	neutral	0.13	neutral	1.15	medium_impact	0.38	medium_impact	-2.03	low_impact	0.68	0.85	28.03	15.07	0.41	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12541	12541	G	C	MI.19671	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	205	69	A	P	Gcc/Ccc	2.25	0.95	0	possibly_damaging	0.73	neutral	0.17	neutral	1.5	neutral	-2.66	neutral	-1.59	low_impact	0.8	0.7	neutral	0.47	neutral	3.45	23.00	deleterious	0.18	0.45	0.72	disease	0.65	disease	0.47	neutral	0.49	neutral	0	0.87	neutral	0.22	neutral	-3	neutral	0.72	deleterious	-1.16	low_impact	-0.15	medium_impact	-0.47	medium_impact	0.83	0.9	28.03	15.07	0.42	N	0.38	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12542	12542	C	A	MI.19672	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	206	69	A	D	gCc/gAc	-0.73	0	0	possibly_damaging	0.66	neutral	0.16	neutral	1.5	deleterious	-3.27	neutral	-2.28	low_impact	1.15	0.69	neutral	0.47	neutral	4.08	23.70	deleterious	0.25	0.45	0.78	disease	0.51	disease	0.65	disease	0.69	disease	4	0.86	neutral	0.25	neutral	-3	neutral	0.63	deleterious	-1.02	low_impact	-0.17	medium_impact	-0.15	medium_impact	0.74	0.85	28.03	15.07	0.32	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12542	12542	C	T	MI.19673	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	206	69	A	V	gCc/gTc	-0.73	0	0	benign	0.02	neutral	0.46	neutral	1.75	neutral	1.51	neutral	2.34	neutral_impact	-0.67	0.88	neutral	0.95	neutral	1.42	12.88	neutral	0.42	0.55	0.2	neutral	0.18	neutral	0.22	neutral	0.32	neutral	4	0.52	neutral	0.72	deleterious	-6	neutral	0.30	neutral	0.86	medium_impact	0.19	medium_impact	-1.82	low_impact	0.86	0.9	28.03	15.07	0.32	N	0.04	polymorphism	1	0.00	rs201922401	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12542	12542	C	G	MI.19674	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	206	69	A	G	gCc/gGc	-0.73	0	0	benign	0.34	neutral	0.3	neutral	1.51	neutral	-2.13	deleterious	-2.51	low_impact	1.15	0.74	neutral	0.62	neutral	2.14	17.12	deleterious	0.31	0.45	0.22	neutral	0.24	neutral	0.45	neutral	0.42	neutral	2	0.64	neutral	0.48	deleterious	-6	neutral	0.38	neutral	-0.47	medium_impact	0.03	medium_impact	-0.15	medium_impact	0.77	0.85	28.03	15.07	0.41	N	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12544	12544	A	T	MI.19675	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	208	70	T	S	Aca/Tca	-0.27	0	0	possibly_damaging	0.44	neutral	0.47	neutral	1.62	neutral	0.35	deleterious	-2.96	neutral_impact	0.38	0.84	neutral	0.98	neutral	0.09	3.49	deleterious	0.48	0.55	0.52	disease	0.2	neutral	0.27	neutral	0.28	neutral	4	0.49	neutral	0.52	deleterious	-3	neutral	0.45	deleterious	-0.65	medium_impact	0.2	medium_impact	-0.86	medium_impact	0.62	0.8	19.57	13.89	0.35	N	0.32	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12544	12544	A	G	MI.19676	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	208	70	T	A	Aca/Gca	-0.27	0	0	benign	0.02	neutral	0.49	neutral	1.54	neutral	-0.6	deleterious	-4.14	medium_impact	2.44	0.85	neutral	0.71	neutral	1.34	12.46	neutral	0.62	0.65	0.47	neutral	0.28	neutral	0.47	neutral	0.46	neutral	1	0.49	neutral	0.74	deleterious	-3	neutral	0.16	neutral	0.86	medium_impact	0.22	medium_impact	1.03	medium_impact	0.44	0.8	19.57	13.89	0.39	N	0.86	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12544	12544	A	C	MI.19677	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	208	70	T	P	Aca/Cca	-0.27	0	0	possibly_damaging	0.81	neutral	0.2	neutral	1.52	neutral	-0.94	deleterious	-5.15	medium_impact	2.36	0.8	neutral	0.67	neutral	3.17	22.70	deleterious	0.2	0.45	0.77	disease	0.74	disease	0.57	disease	0.7	disease	4	0.89	neutral	0.2	neutral	0	NA	0.78	deleterious	-1.34	low_impact	-0.1	medium_impact	0.95	medium_impact	0.50	0.8	19.57	13.89	0.3	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12545	12545	C	T	MI.19678	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	209	70	T	M	aCa/aTa	0.18	0	0	benign	0.16	neutral	0.27	neutral	1.46	neutral	-2.96	deleterious	-5.14	medium_impact	2.13	0.85	neutral	0.67	neutral	3.77	23.40	deleterious	0.37	0.5	0.42	neutral	0.35	neutral	0.36	neutral	0.47	neutral	1	0.68	neutral	0.56	deleterious	-3	neutral	0.67	deleterious	-0.06	medium_impact	-0.01	medium_impact	0.74	medium_impact	0.70	0.85	19.57	13.89	0.42	N	0.45	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12545	12545	C	A	MI.19679	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	209	70	T	K	aCa/aAa	0.18	0	0	possibly_damaging	0.64	neutral	0.28	neutral	1.55	neutral	-0.38	deleterious	-5.02	medium_impact	2.13	0.76	neutral	0.57	neutral	4.00	23.60	deleterious	0.29	0.45	0.64	disease	0.51	disease	0.53	disease	0.53	disease	1	0.75	neutral	0.32	neutral	0	NA	0.65	deleterious	-0.98	medium_impact	0.01	medium_impact	0.74	medium_impact	0.65	0.8	19.57	13.89	0.35	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5944	5944	A	G	MI.1968	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	41	14	D	G	gAc/gGc	9.38	1	0	probably_damaging	1	deleterious	0.01	neutral	-1.22	neutral	-1.86	neutral	-1.35	high_impact	3.99	0.64	neutral	0.06	damaging	3.76	23.30	deleterious	0.29	0.55	0.44	neutral	0.9	disease	0.64	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-0.92	medium_impact	2.59	high_impact	0.56	0.9	1.56	6.7	0.49	P	0.85	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12547	12547	A	T	MI.19680	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	211	71	T	S	Acc/Tcc	-7.61	0	0	benign	0.36	neutral	0.4	neutral	1.57	neutral	-0.11	neutral	-1.05	low_impact	1.12	0.78	neutral	0.81	neutral	2.07	16.69	deleterious	0.53	0.6	0.44	neutral	0.26	neutral	0.55	disease	0.48	neutral	0	0.53	neutral	0.52	deleterious	-6	neutral	0.44	deleterious	-0.51	medium_impact	0.14	medium_impact	-0.18	medium_impact	0.63	0.8	13.76	13.42	0.35	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12547	12547	A	C	MI.19681	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	211	71	T	P	Acc/Ccc	-7.61	0	0	possibly_damaging	0.83	neutral	0.2	neutral	1.41	deleterious	-3.62	neutral	-2.03	medium_impact	2	0.67	neutral	0.43	neutral	3.71	23.30	deleterious	0.21	0.45	0.79	disease	0.8	disease	0.67	disease	0.77	disease	5	0.9	neutral	0.19	neutral	0	NA	0.78	deleterious	-1.4	low_impact	-0.1	medium_impact	0.62	medium_impact	0.53	0.8	13.76	13.42	0.27	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12547	12547	A	G	MI.19682	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	211	71	T	A	Acc/Gcc	-7.61	0	0	benign	0.01	neutral	0.5	neutral	1.49	neutral	-1.02	neutral	-0.19	low_impact	1.73	0.86	neutral	0.78	neutral	1.87	15.41	deleterious	0.69	0.75	0.41	neutral	0.34	neutral	0.56	disease	0.49	neutral	0	0.48	neutral	0.75	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.23	medium_impact	0.38	medium_impact	0.30	0.8	13.76	13.42	0.35	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12548	12548	C	G	MI.19683	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	212	71	T	S	aCc/aGc	2.94	0.02	0	benign	0.36	neutral	0.4	neutral	1.57	neutral	-0.11	neutral	-1.05	low_impact	1.12	0.78	neutral	0.81	neutral	1.76	14.77	neutral	0.53	0.6	0.44	neutral	0.26	neutral	0.55	disease	0.48	neutral	0	0.53	neutral	0.52	deleterious	-6	neutral	0.44	deleterious	-0.51	medium_impact	0.14	medium_impact	-0.18	medium_impact	0.63	0.8	13.76	13.42	0.37	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12548	12548	C	T	MI.19684	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	212	71	T	I	aCc/aTc	2.94	0.02	0	benign	0.01	neutral	0.39	neutral	1.58	neutral	-0.03	neutral	4	neutral_impact	-0.4	0.88	neutral	0.98	neutral	0.84	9.70	deleterious	0.43	0.55	0.3	neutral	0.19	neutral	0.28	neutral	0.36	neutral	3	0.6	neutral	0.69	deleterious	-6	neutral	0.55	deleterious	1.15	medium_impact	0.13	medium_impact	-1.57	low_impact	0.56	0.8	13.76	13.42	0.36	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12548	12548	C	A	MI.19685	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	212	71	T	N	aCc/aAc	2.94	0.02	0	possibly_damaging	0.81	neutral	0.31	neutral	1.49	neutral	-1.01	neutral	-2.05	low_impact	1.87	0.75	neutral	0.73	neutral	3.50	23.10	deleterious	0.57	0.65	0.73	disease	0.62	disease	0.68	disease	0.58	disease	2	0.84	neutral	0.25	neutral	-3	neutral	0.68	deleterious	-1.34	low_impact	0.04	medium_impact	0.51	medium_impact	0.66	0.8	13.76	13.42	0.36	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12550	12550	C	A	MI.19686	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	214	72	Q	K	Caa/Aaa	-6.01	0	0	probably_damaging	1	neutral	0.3	neutral	1.56	neutral	-0.3	deleterious	-3.01	medium_impact	2.31	0.78	neutral	0.43	neutral	2.75	21.10	deleterious	0.56	0.6	0.22	neutral	0.29	neutral	0.49	neutral	0.43	neutral	1	1	deleterious	0.15	neutral	1	deleterious	0.66	deleterious	-3.6	low_impact	0.03	medium_impact	0.91	medium_impact	0.53	0.8	22.89	16.75	0.35	N	0.62	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12550	12550	C	G	MI.19687	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	214	72	Q	E	Caa/Gaa	-6.01	0	0	probably_damaging	1	neutral	0.29	neutral	1.62	neutral	0.29	neutral	-2.13	low_impact	1.72	0.81	neutral	0.73	neutral	1.76	14.74	neutral	0.62	0.65	0.4	neutral	0.22	neutral	0.5	neutral	0.41	neutral	2	1	deleterious	0.15	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.02	medium_impact	0.37	medium_impact	0.62	0.8	22.89	16.75	0.36	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12551	12551	A	T	MI.19688	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	215	72	Q	L	cAa/cTa	-1.42	0	0	probably_damaging	1	neutral	0.67	neutral	1.47	neutral	-2.2	deleterious	-5.76	low_impact	1.82	0.75	neutral	0.76	neutral	2.13	17.07	deleterious	0.35	0.5	0.27	neutral	0.21	neutral	0.3	neutral	0.37	neutral	3	1	deleterious	0.34	neutral	-2	neutral	0.66	deleterious	-3.6	low_impact	0.4	medium_impact	0.46	medium_impact	0.24	0.8	22.89	16.75	0.31	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12551	12551	A	C	MI.19689	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	215	72	Q	P	cAa/cCa	-1.42	0	0	probably_damaging	1	neutral	0.21	neutral	1.47	neutral	-1.97	deleterious	-4.78	medium_impact	2.19	0.72	neutral	0.7	neutral	3.07	22.40	deleterious	0.24	0.45	0.55	disease	0.59	disease	0.52	disease	0.48	neutral	0	1	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	-0.09	medium_impact	0.8	medium_impact	0.36	0.8	22.89	16.75	0.34	N	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5945	5945	C	A	MI.1969	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	42	14	D	E	gaC/gaA	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	-1.19	neutral	-0.53	neutral	-0.77	high_impact	3.64	0.55	damaging	0.07	damaging	4.04	23.70	deleterious	0.54	0.6	0.2	neutral	0.84	disease	0.47	neutral	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.26	high_impact	0.69	0.9	1.56	6.7	0.51	P	0.65	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12551	12551	A	G	MI.19690	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	215	72	Q	R	cAa/cGa	-1.42	0	0	probably_damaging	1	neutral	0.35	neutral	1.5	neutral	-1.28	deleterious	-2.84	medium_impact	3	0.76	neutral	0.44	neutral	2.20	17.51	deleterious	0.57	0.65	0.5	disease	0.31	neutral	0.53	disease	0.34	neutral	3	1	deleterious	0.18	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.08	medium_impact	1.54	medium_impact	0.43	0.8	22.89	16.75	0.36	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12552	12552	A	T	MI.19691	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	216	72	Q	H	caA/caT	-0.73	0	0	probably_damaging	1	neutral	0.55	neutral	1.47	neutral	-1.98	neutral	-2.11	low_impact	1.75	0.78	neutral	0.96	neutral	1.85	15.28	deleterious	0.62	0.65	0.67	disease	0.17	neutral	0.3	neutral	0.43	neutral	1	1	deleterious	0.28	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.28	medium_impact	0.4	medium_impact	0.59	0.8	22.89	16.75	0.29	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12552	12552	A	C	MI.19692	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	216	72	Q	H	caA/caC	-0.73	0	0	probably_damaging	1	neutral	0.55	neutral	1.47	neutral	-1.98	neutral	-2.11	low_impact	1.75	0.78	neutral	0.96	neutral	1.62	13.99	neutral	0.62	0.65	0.67	disease	0.17	neutral	0.3	neutral	0.43	neutral	1	1	deleterious	0.28	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.28	medium_impact	0.4	medium_impact	0.59	0.8	22.89	16.75	0.29	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12553	12553	A	T	MI.19693	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	217	73	T	S	Aca/Tca	-3.26	0	0	benign	0.18	neutral	0.43	neutral	1.71	neutral	1.27	deleterious	-2.6	low_impact	0.87	0.9	neutral	0.96	neutral	1.68	14.32	neutral	0.55	0.6	NA	NA	0.22	neutral	0.3	neutral	0.19	neutral	6	0.48	neutral	0.63	deleterious	-6	neutral	0.70	deleterious	-0.12	medium_impact	0.17	medium_impact	-0.41	medium_impact	0.64	0.8	12.77	11.07	0.45	N	0.15	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12553	12553	A	C	MI.19694	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	217	73	T	P	Aca/Cca	-3.26	0	0	probably_damaging	0.97	neutral	0.2	neutral	1.55	neutral	-0.73	deleterious	-5.06	medium_impact	2.04	0.8	neutral	0.62	neutral	3.24	22.80	deleterious	0.22	0.45	NA	NA	0.71	disease	0.5	neutral	0.53	disease	1	0.98	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-2.18	low_impact	-0.1	medium_impact	0.66	medium_impact	0.44	0.8	12.77	11.07	0.32	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12553	12553	A	G	MI.19695	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	217	73	T	A	Aca/Gca	-3.26	0	0	possibly_damaging	0.73	neutral	0.48	neutral	1.66	neutral	0.87	deleterious	-3.98	medium_impact	2.54	0.77	neutral	0.62	neutral	3.17	22.70	deleterious	0.61	0.65	NA	NA	0.27	neutral	0.53	disease	0.35	neutral	3	0.71	neutral	0.38	neutral	0	NA	0.72	deleterious	-1.16	low_impact	0.21	medium_impact	1.12	medium_impact	0.51	0.8	12.77	11.07	0.33	N	0.70	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12554	12554	C	T	MI.19696	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	218	73	T	M	aCa/aTa	0.18	0	0	probably_damaging	0.99	neutral	0.24	neutral	1.53	neutral	-1.19	deleterious	-5.09	medium_impact	2.7	0.77	neutral	0.65	neutral	2.74	21.00	deleterious	0.38	0.5	NA	NA	0.35	neutral	0.38	neutral	0.18	neutral	6	0.99	deleterious	0.13	neutral	1	deleterious	0.71	deleterious	-2.64	low_impact	-0.04	medium_impact	1.26	medium_impact	0.70	0.85	12.77	11.07	0.4	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12554	12554	C	A	MI.19697	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	218	73	T	K	aCa/aAa	0.18	0	0	possibly_damaging	0.88	neutral	0.31	neutral	1.59	neutral	0.06	deleterious	-4.86	medium_impact	3.4	0.76	neutral	0.38	neutral	4.37	24.10	deleterious	0.35	0.5	NA	NA	0.6	disease	0.74	disease	0.75	disease	5	0.9	neutral	0.22	neutral	0	NA	0.76	deleterious	-1.57	low_impact	0.04	medium_impact	1.9	medium_impact	0.64	0.8	12.77	11.07	0.38	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12556	12556	A	G	MI.19698	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	220	74	T	A	Acc/Gcc	-10.14	0	0	benign	0.08	neutral	0.53	neutral	1.59	neutral	0.15	neutral	-0.39	low_impact	1.43	0.78	neutral	0.77	neutral	1.97	16.03	deleterious	0.63	0.7	NA	NA	0.23	neutral	0.53	disease	0.31	neutral	4	0.4	neutral	0.73	deleterious	-6	neutral	0.21	neutral	0.26	medium_impact	0.26	medium_impact	0.1	medium_impact	0.34	0.8	18.91	11.5	0.31	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12556	12556	A	T	MI.19699	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	220	74	T	S	Acc/Tcc	-10.14	0	0	benign	0.36	neutral	0.5	neutral	1.55	neutral	-0.91	neutral	-0.94	neutral_impact	0.76	0.74	neutral	0.83	neutral	2.06	16.57	deleterious	0.52	0.6	NA	NA	0.23	neutral	0.5	neutral	0.17	neutral	7	0.42	neutral	0.57	deleterious	-6	neutral	0.41	neutral	-0.51	medium_impact	0.23	medium_impact	-0.51	medium_impact	0.55	0.8	18.91	11.5	0.39	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8618	8618	T	G	MI.197	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	92	31	I	S	aTc/aGc	-0.33	0	0.01	benign	0.22	neutral	0.08	neutral	4.37	neutral	-1.3	neutral	-2.5	low_impact	1.75	0.83	neutral	0.52	neutral	2.33	18.39	deleterious	0.37	0.65	0.45	neutral	0.65	disease	0.24	neutral	0.52	disease	0	0.91	neutral	0.43	neutral	-6	neutral	0.29	neutral	-0.23	medium_impact	-0.31	medium_impact	0.4	medium_impact	0.35	0.9	28.32	22.32	0.36	N	0.42	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5945	5945	C	G	MI.1970	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	42	14	D	E	gaC/gaG	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	-1.19	neutral	-0.53	neutral	-0.77	high_impact	3.64	0.55	damaging	0.07	damaging	3.71	23.30	deleterious	0.54	0.6	0.2	neutral	0.84	disease	0.47	neutral	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.26	high_impact	0.69	0.9	1.56	6.7	0.51	P	0.65	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12556	12556	A	C	MI.19700	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	220	74	T	P	Acc/Ccc	-10.14	0	0	possibly_damaging	0.58	neutral	0.23	neutral	1.52	neutral	-2.45	neutral	-2.03	medium_impact	2.12	0.64	neutral	0.39	neutral	3.57	23.10	deleterious	0.24	0.45	NA	NA	0.72	disease	0.48	neutral	0.52	disease	0	0.77	neutral	0.33	neutral	0	NA	0.68	deleterious	-0.88	medium_impact	-0.06	medium_impact	0.73	medium_impact	0.51	0.8	18.91	11.5	0.34	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12557	12557	C	T	MI.19701	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	221	74	T	I	aCc/aTc	-1.19	0	0.01	benign	0	neutral	0.47	neutral	1.66	neutral	0.99	neutral	2.1	neutral_impact	0.27	0.87	neutral	0.96	neutral	0.48	7.28	deleterious	0.44	0.55	NA	NA	0.37	neutral	0.25	neutral	0.17	neutral	7	0.52	neutral	0.74	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	0.2	medium_impact	-0.96	medium_impact	0.52	0.8	18.91	11.5	0.3	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12557	12557	C	A	MI.19702	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	221	74	T	N	aCc/aAc	-1.19	0	0.01	possibly_damaging	0.58	neutral	0.37	neutral	1.52	neutral	-2.15	neutral	-1.93	medium_impact	2.12	0.66	neutral	0.62	neutral	3.33	22.90	deleterious	0.57	0.65	NA	NA	0.58	disease	0.53	disease	0.59	disease	2	0.65	neutral	0.4	neutral	0	NA	0.61	deleterious	-0.88	medium_impact	0.11	medium_impact	0.73	medium_impact	0.66	0.8	18.91	11.5	0.34	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12557	12557	C	G	MI.19703	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	221	74	T	S	aCc/aGc	-1.19	0	0.01	benign	0.36	neutral	0.5	neutral	1.55	neutral	-0.91	neutral	-0.94	neutral_impact	0.76	0.74	neutral	0.83	neutral	1.74	14.66	neutral	0.52	0.6	NA	NA	0.23	neutral	0.5	neutral	0.17	neutral	7	0.42	neutral	0.57	deleterious	-6	neutral	0.41	neutral	-0.51	medium_impact	0.23	medium_impact	-0.51	medium_impact	0.55	0.8	18.91	11.5	0.39	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12559	12559	C	G	MI.19704	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	223	75	Q	E	Cag/Gag	-3.94	0	0	benign	0	neutral	0.32	neutral	1.63	neutral	0.76	neutral	0.01	neutral_impact	-0.51	0.9	neutral	0.96	neutral	-0.35	0.50	neutral	0.59	0.65	NA	NA	0.34	neutral	0.25	neutral	0.17	neutral	7	0.68	neutral	0.66	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.05	medium_impact	-1.67	low_impact	0.57	0.8	26.87	19.98	0.39	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12559	12559	C	A	MI.19705	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	223	75	Q	K	Cag/Aag	-3.94	0	0	benign	0.01	neutral	0.33	neutral	1.72	neutral	1.61	neutral	2.41	neutral_impact	-1.31	0.8	neutral	0.93	neutral	-0.45	0.29	neutral	0.68	0.7	NA	NA	0.14	neutral	0.22	neutral	0.21	neutral	6	0.66	neutral	0.66	deleterious	-6	neutral	0.27	neutral	1.15	medium_impact	0.06	medium_impact	-2.4	low_impact	0.56	0.8	26.87	19.98	0.34	N	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12560	12560	A	G	MI.19706	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	224	75	Q	R	cAg/cGg	-0.27	0	0	benign	0.18	neutral	0.36	neutral	1.58	neutral	-0.2	neutral	0.43	low_impact	1.15	0.69	neutral	0.47	neutral	1.67	14.21	neutral	0.73	0.75	NA	NA	0.46	neutral	0.55	disease	0.4	neutral	2	0.57	neutral	0.59	deleterious	-6	neutral	0.45	deleterious	-0.12	medium_impact	0.1	medium_impact	-0.15	medium_impact	0.40	0.8	26.87	19.98	0.4	N	0.29	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12560	12560	A	T	MI.19707	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	224	75	Q	L	cAg/cTg	-0.27	0	0	benign	0.29	neutral	0.66	neutral	1.6	neutral	0.24	deleterious	-3.05	low_impact	0.8	0.78	neutral	0.56	neutral	3.40	23.00	deleterious	0.4	0.5	NA	NA	0.43	neutral	0.48	neutral	0.21	neutral	6	0.25	neutral	0.69	deleterious	-6	neutral	0.51	deleterious	-0.38	medium_impact	0.39	medium_impact	-0.47	medium_impact	0.23	0.8	26.87	19.98	0.22	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12560	12560	A	C	MI.19708	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	224	75	Q	P	cAg/cCg	-0.27	0	0	benign	0.36	neutral	0.21	neutral	1.54	neutral	-1.64	neutral	-2.05	neutral_impact	0.34	0.71	neutral	0.72	neutral	2.96	22.10	deleterious	0.23	0.45	NA	NA	0.71	disease	0.31	neutral	0.52	disease	0	0.75	neutral	0.43	neutral	-6	neutral	0.63	deleterious	-0.51	medium_impact	-0.09	medium_impact	-0.89	medium_impact	0.41	0.8	26.87	19.98	0.36	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12561	12561	G	T	MI.19709	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	225	75	Q	H	caG/caT	2.25	0	0.01	possibly_damaging	0.65	neutral	0.53	neutral	1.64	neutral	0.81	neutral	-1.13	neutral_impact	0.6	0.74	neutral	0.71	neutral	2.27	17.97	deleterious	0.64	0.7	NA	NA	0.26	neutral	0.4	neutral	0.15	neutral	7	0.61	neutral	0.44	neutral	-3	neutral	0.64	deleterious	-1	low_impact	0.26	medium_impact	-0.66	medium_impact	0.68	0.85	26.87	19.98	0.33	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5946	5946	A	C	MI.1971	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	43	15	I	L	Att/Ctt	-2.88	0	0	probably_damaging	0.97	deleterious	0	neutral	-0.43	neutral	-2.88	neutral	-0.42	medium_impact	3.3	0.58	damaging	0.16	damaging	3.42	23.00	deleterious	0.34	0.55	0.35	neutral	0.79	disease	0.65	disease	0.7	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.69	deleterious	-2.18	low_impact	-1.48	low_impact	1.95	medium_impact	0.78	0.9	1.17	6.73	0.35	N	0.61	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12561	12561	G	C	MI.19710	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	225	75	Q	H	caG/caC	2.25	0	0.01	possibly_damaging	0.65	neutral	0.53	neutral	1.64	neutral	0.81	neutral	-1.13	neutral_impact	0.6	0.74	neutral	0.71	neutral	2.15	17.20	deleterious	0.64	0.7	NA	NA	0.26	neutral	0.4	neutral	0.15	neutral	7	0.61	neutral	0.44	neutral	-3	neutral	0.64	deleterious	-1	low_impact	0.26	medium_impact	-0.66	medium_impact	0.68	0.85	26.87	19.98	0.33	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12562	12562	C	T	MI.19711	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	226	76	L	F	Ctc/Ttc	-2.8	0	0.02	probably_damaging	0.98	neutral	0.84	neutral	1.43	neutral	-1.01	deleterious	-3.4	medium_impact	2.25	0.83	neutral	0.56	neutral	3.75	23.30	deleterious	0.4	0.5	NA	NA	0.53	disease	0.44	neutral	0.46	neutral	1	0.98	neutral	0.43	neutral	1	deleterious	0.75	deleterious	-2.35	low_impact	0.63	medium_impact	0.85	medium_impact	0.70	0.85	9.12	10.32	0.19	N	0.86	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12562	12562	C	A	MI.19712	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	226	76	L	I	Ctc/Atc	-2.8	0	0.02	benign	0.38	neutral	0.48	neutral	1.63	neutral	0.28	neutral	-1.33	neutral_impact	0.5	0.78	neutral	0.9	neutral	1.93	15.76	deleterious	0.38	0.5	NA	NA	0.03	neutral	0.16	neutral	0.19	neutral	6	0.45	neutral	0.55	deleterious	-6	neutral	0.68	deleterious	-0.54	medium_impact	0.21	medium_impact	-0.75	medium_impact	0.80	0.85	9.12	10.32	0.45	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12562	12562	C	G	MI.19713	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	226	76	L	V	Ctc/Gtc	-2.8	0	0.02	possibly_damaging	0.76	neutral	0.5	neutral	1.59	neutral	-0.57	neutral	-2.29	low_impact	1.8	0.73	neutral	0.78	neutral	2.05	16.53	deleterious	0.34	0.5	NA	NA	0.19	neutral	0.27	neutral	0.2	neutral	6	0.74	neutral	0.37	neutral	-3	neutral	0.70	deleterious	-1.22	low_impact	0.23	medium_impact	0.44	medium_impact	0.68	0.85	9.12	10.32	0.35	N	0.62	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12563	12563	T	A	MI.19714	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	227	76	L	H	cTc/cAc	-1.88	0	0	probably_damaging	1	neutral	0.5	neutral	1.33	deleterious	-4.71	deleterious	-6.42	high_impact	3.61	0.73	neutral	0.43	neutral	4.04	23.70	deleterious	0.15	0.4	NA	NA	0.65	disease	0.68	disease	0.72	disease	4	0.99	deleterious	0.25	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.23	medium_impact	2.1	high_impact	0.56	0.8	9.12	10.32	0.29	N	0.85	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12563	12563	T	C	MI.19715	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	227	76	L	P	cTc/cCc	-1.88	0	0	probably_damaging	1	neutral	0.19	neutral	1.33	deleterious	-3.82	deleterious	-6.49	medium_impact	3.27	0.57	damaging	0.3	neutral	3.75	23.30	deleterious	0.11	0.4	NA	NA	0.85	disease	0.6	disease	0.78	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	-0.12	medium_impact	1.78	medium_impact	0.55	0.8	9.12	10.32	0.3	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12563	12563	T	G	MI.19716	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	227	76	L	R	cTc/cGc	-1.88	0	0	probably_damaging	1	neutral	0.33	neutral	1.34	deleterious	-4.02	deleterious	-5.65	high_impact	3.61	0.68	neutral	0.36	neutral	4.06	23.70	deleterious	0.11	0.4	NA	NA	0.84	disease	0.73	disease	0.8	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.06	medium_impact	2.1	high_impact	0.56	0.8	9.12	10.32	0.3	N	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12565	12565	T	G	MI.19717	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	229	77	S	A	Tcc/Gcc	-7.38	0	0	possibly_damaging	0.45	neutral	0.75	neutral	1.46	neutral	-1.32	neutral	-1.94	medium_impact	2.42	0.86	neutral	0.77	neutral	3.48	23.10	deleterious	0.43	0.55	NA	NA	0.28	neutral	0.49	neutral	0.18	neutral	6	0.35	neutral	0.65	deleterious	0	NA	0.72	deleterious	-0.66	medium_impact	0.5	medium_impact	1.01	medium_impact	0.74	0.85	11.94	12.21	0.28	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12565	12565	T	A	MI.19718	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	229	77	S	T	Tcc/Acc	-7.38	0	0	benign	0.04	neutral	0.58	neutral	1.45	neutral	-1.42	neutral	-0.66	neutral_impact	0.52	0.9	neutral	0.99	neutral	1.96	15.97	deleterious	0.29	0.45	NA	NA	0.23	neutral	0.31	neutral	0.17	neutral	7	0.37	neutral	0.77	deleterious	-6	neutral	0.71	deleterious	0.57	medium_impact	0.31	medium_impact	-0.73	medium_impact	0.79	0.85	11.94	12.21	0.38	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12565	12565	T	C	MI.19719	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	229	77	S	P	Tcc/Ccc	-7.38	0	0	possibly_damaging	0.86	neutral	0.29	neutral	1.43	neutral	-1.86	deleterious	-3.52	low_impact	1.49	0.76	neutral	0.8	neutral	3.79	23.40	deleterious	0.2	0.45	NA	NA	0.7	disease	0.35	neutral	0.52	disease	0	0.89	neutral	0.22	neutral	-3	neutral	0.81	deleterious	-1.5	low_impact	0.02	medium_impact	0.16	medium_impact	0.69	0.85	11.94	12.21	0.36	N	0.86	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5946	5946	A	G	MI.1972	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	43	15	I	V	Att/Gtt	-2.88	0	0	probably_damaging	0.92	deleterious	0.04	neutral	-0.37	neutral	-2.22	neutral	-0.21	high_impact	3.65	0.65	neutral	0.15	damaging	2.70	20.80	deleterious	0.51	0.6	0.3	neutral	0.56	disease	0.57	disease	0.65	disease	3	0.99	deleterious	0.06	neutral	6	deleterious	0.62	deleterious	-1.76	low_impact	-0.58	medium_impact	2.27	high_impact	0.64	0.9	1.17	6.73	0.44	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12566	12566	C	A	MI.19720	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	230	77	S	Y	tCc/tAc	-1.88	0	0	probably_damaging	0.93	neutral	1	neutral	1.39	deleterious	-3.78	deleterious	-4.13	low_impact	1.92	0.79	neutral	0.77	neutral	3.87	23.50	deleterious	0.28	0.45	NA	NA	0.61	disease	0.47	neutral	0.47	neutral	1	0.93	neutral	0.54	deleterious	-2	neutral	0.77	deleterious	-1.81	low_impact	1.89	high_impact	0.55	medium_impact	0.74	0.85	11.94	12.21	0.19	N	0.93	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12566	12566	C	G	MI.19721	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	230	77	S	C	tCc/tGc	-1.88	0	0	probably_damaging	0.97	neutral	0.19	neutral	1.38	deleterious	-5.2	deleterious	-2.88	medium_impact	2.96	0.87	neutral	0.56	neutral	3.42	23.00	deleterious	0.36	0.5	NA	NA	0.69	disease	0.4	neutral	0.51	disease	0	0.98	neutral	0.11	neutral	1	deleterious	0.76	deleterious	-2.18	low_impact	-0.12	medium_impact	1.5	medium_impact	0.68	0.85	11.94	12.21	0.42	N	0.50	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12566	12566	C	T	MI.19722	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	230	77	S	F	tCc/tTc	-1.88	0	0	possibly_damaging	0.84	neutral	0.71	neutral	1.38	deleterious	-4.24	deleterious	-4.16	medium_impact	2.27	0.82	neutral	0.68	neutral	3.04	22.40	deleterious	0.24	0.45	NA	NA	0.71	disease	0.48	neutral	0.51	disease	0	0.81	neutral	0.44	neutral	0	NA	0.77	deleterious	-1.43	low_impact	0.45	medium_impact	0.87	medium_impact	0.38	0.8	11.94	12.21	0.23	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12568	12568	C	G	MI.19723	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	232	78	L	V	Cta/Gta	-20	0	0	possibly_damaging	0.9	neutral	0.48	neutral	1.49	neutral	-0.9	neutral	-1.71	medium_impact	2.3	0.86	neutral	0.87	neutral	2.14	17.10	deleterious	0.34	0.5	NA	NA	0.28	neutral	0.32	neutral	0.18	neutral	6	0.89	neutral	0.29	neutral	0	NA	0.72	deleterious	-1.65	low_impact	0.21	medium_impact	0.9	medium_impact	0.78	0.85	15.42	13.26	0.35	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12568	12568	C	A	MI.19724	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	232	78	L	M	Cta/Ata	-20	0	0	possibly_damaging	0.66	neutral	0.3	neutral	1.53	neutral	-0.45	neutral	-0.22	neutral_impact	0.6	0.85	neutral	0.96	neutral	1.34	12.49	neutral	0.28	0.45	NA	NA	0.16	neutral	0.22	neutral	0.21	neutral	6	0.75	neutral	0.32	neutral	-3	neutral	0.70	deleterious	-1.02	low_impact	0.03	medium_impact	-0.66	medium_impact	0.75	0.85	15.42	13.26	0.44	N	0.11	polymorphism	1	0.01	rs28411793	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12569	12569	T	G	MI.19725	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	233	78	L	R	cTa/cGa	-2.34	0	0	probably_damaging	0.98	neutral	0.34	neutral	1.39	deleterious	-3.52	deleterious	-4.55	high_impact	3.54	0.69	neutral	0.42	neutral	4.01	23.60	deleterious	0.08	0.35	NA	NA	0.8	disease	0.72	disease	0.77	disease	5	0.99	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-2.35	low_impact	0.07	medium_impact	2.03	high_impact	0.56	0.8	15.42	13.26	0.34	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12569	12569	T	A	MI.19726	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	233	78	L	Q	cTa/cAa	-2.34	0	0	probably_damaging	0.99	neutral	0.28	neutral	1.39	deleterious	-3.67	deleterious	-4.22	high_impact	3.54	0.72	neutral	0.53	neutral	3.93	23.50	deleterious	0.11	0.4	NA	NA	0.62	disease	0.61	disease	0.7	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.79	deleterious	-2.64	low_impact	0.01	medium_impact	2.03	high_impact	0.79	0.85	15.42	13.26	0.39	N	0.79	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12569	12569	T	C	MI.19727	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	233	78	L	P	cTa/cCa	-2.34	0	0	probably_damaging	1	neutral	0.2	neutral	1.38	deleterious	-4.08	deleterious	-5.37	medium_impact	2.99	0.6	neutral	0.33	neutral	3.76	23.40	deleterious	0.09	0.35	NA	NA	0.81	disease	0.6	disease	0.75	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	-0.1	medium_impact	1.53	medium_impact	0.68	0.85	15.42	13.26	0.29	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	COSM1155523	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12571	12571	A	T	MI.19728	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	235	79	S	C	Agc/Tgc	-10.83	0	0	probably_damaging	0.99	neutral	0.18	neutral	1.37	deleterious	-5.27	deleterious	-4.78	high_impact	3.77	0.74	neutral	0.13	damaging	3.27	22.80	deleterious	0.26	0.45	NA	NA	0.77	disease	0.7	disease	0.72	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.80	deleterious	-2.64	low_impact	-0.13	medium_impact	2.24	high_impact	0.53	0.8	4.15	8.78	0.32	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12571	12571	A	C	MI.19729	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	235	79	S	R	Agc/Cgc	-10.83	0	0	probably_damaging	0.96	neutral	0.36	neutral	1.41	neutral	-1.86	deleterious	-4.33	high_impact	4.12	0.74	neutral	0.14	damaging	3.69	23.30	deleterious	0.18	0.45	NA	NA	0.85	disease	0.81	disease	0.8	disease	6	0.96	neutral	0.2	neutral	2	deleterious	0.87	deleterious	-2.06	low_impact	0.1	medium_impact	2.56	high_impact	0.75	0.85	4.15	8.78	0.44	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5946	5946	A	T	MI.1973	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	43	15	I	F	Att/Ttt	-2.88	0	0	probably_damaging	1	deleterious	0	neutral	-0.52	deleterious	-5.77	neutral	-0.83	high_impact	4.8	0.6	damaging	0.1	damaging	3.39	23.00	deleterious	0.22	0.55	0.77	disease	0.87	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.33	high_impact	0.76	0.9	1.17	6.73	0.68	P	0.85	polymorphism	0.67	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12571	12571	A	G	MI.19730	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	235	79	S	G	Agc/Ggc	-10.83	0	0	possibly_damaging	0.73	neutral	0.34	neutral	1.55	neutral	0.06	deleterious	-3.49	medium_impact	2.73	0.65	neutral	0.24	damaging	3.44	23.00	deleterious	0.34	0.5	NA	NA	0.5	neutral	0.64	disease	0.45	neutral	1	0.77	neutral	0.31	neutral	0	NA	0.76	deleterious	-1.16	low_impact	0.07	medium_impact	1.29	medium_impact	0.70	0.85	4.15	8.78	0.32	N	0.86	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12572	12572	G	A	MI.19731	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	236	79	S	N	aGc/aAc	2.94	0.12	0	benign	0.12	neutral	0.32	neutral	1.46	neutral	-1.43	neutral	-1.77	low_impact	1.77	0.76	neutral	0.83	neutral	2.37	18.62	deleterious	0.53	0.6	NA	NA	0.61	disease	0.64	disease	0.46	neutral	1	0.63	neutral	0.6	deleterious	-6	neutral	0.80	deleterious	0.08	medium_impact	0.05	medium_impact	0.41	medium_impact	0.55	0.8	4.15	8.78	0.37	N	0.87	disease_causing	0.59	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12572	12572	G	C	MI.19732	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	236	79	S	T	aGc/aCc	2.94	0.12	0	possibly_damaging	0.86	neutral	0.41	neutral	1.43	neutral	-0.61	deleterious	-2.66	medium_impact	2.31	0.7	neutral	0.25	damaging	3.25	22.80	deleterious	0.27	0.45	NA	NA	0.48	neutral	0.6	disease	0.37	neutral	3	0.86	neutral	0.28	neutral	0	NA	0.77	deleterious	-1.5	low_impact	0.15	medium_impact	0.91	medium_impact	0.80	0.85	4.15	8.78	0.34	N	0.71	disease_causing	0.54	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12572	12572	G	T	MI.19733	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	236	79	S	I	aGc/aTc	2.94	0.12	0	probably_damaging	0.98	neutral	0.4	neutral	1.39	neutral	-2.92	deleterious	-5.61	medium_impact	3.42	0.7	neutral	0.13	damaging	3.94	23.50	deleterious	0.24	0.45	NA	NA	0.83	disease	0.73	disease	0.76	disease	5	0.99	deleterious	0.21	neutral	1	deleterious	0.83	deleterious	-2.35	low_impact	0.14	medium_impact	1.92	medium_impact	0.87	0.9	4.15	8.78	0.33	N	0.99	disease_causing	0.92	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12574	12574	T	G	MI.19734	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	238	80	F	V	Ttc/Gtc	-1.19	0	0	possibly_damaging	0.81	neutral	0.51	neutral	0.96	deleterious	-3.84	deleterious	-5.45	high_impact	3.77	0.82	neutral	0.56	neutral	4.02	23.60	deleterious	0.25	0.45	NA	NA	0.79	disease	0.66	disease	0.66	disease	3	0.79	neutral	0.35	neutral	1	deleterious	0.81	deleterious	-1.34	low_impact	0.24	medium_impact	2.24	high_impact	0.72	0.85	4.15	10.6	0.31	N	0.95	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12574	12574	T	A	MI.19735	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	238	80	F	I	Ttc/Atc	-1.19	0	0	possibly_damaging	0.81	neutral	0.4	neutral	1.1	neutral	-1.99	deleterious	-4.46	medium_impact	2.19	0.8	neutral	0.76	neutral	4.26	23.90	deleterious	0.2	0.45	NA	NA	0.64	disease	0.49	neutral	0.47	neutral	1	0.82	neutral	0.3	neutral	0	NA	0.78	deleterious	-1.34	low_impact	0.14	medium_impact	0.8	medium_impact	0.76	0.85	4.15	10.6	0.31	N	0.95	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12574	12574	T	C	MI.19736	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	238	80	F	L	Ttc/Ctc	-1.19	0	0	benign	0.12	neutral	0.67	neutral	1.25	neutral	-1.16	deleterious	-4.23	medium_impact	2.02	0.82	neutral	0.9	neutral	2.63	20.40	deleterious	0.46	0.55	NA	NA	0.38	neutral	0.41	neutral	0.17	neutral	7	0.22	neutral	0.78	deleterious	-3	neutral	0.73	deleterious	0.08	medium_impact	0.4	medium_impact	0.64	medium_impact	0.81	0.85	4.15	10.6	0.31	N	0.92	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12575	12575	T	A	MI.19737	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	239	80	F	Y	tTc/tAc	0.87	0.69	0	probably_damaging	0.92	neutral	1	neutral	1.03	neutral	-2.65	deleterious	-2.61	high_impact	3.77	0.75	neutral	0.42	neutral	4.12	23.80	deleterious	0.23	0.45	NA	NA	0.68	disease	0.73	disease	0.7	disease	4	0.92	neutral	0.54	deleterious	2	deleterious	0.81	deleterious	-1.75	low_impact	1.89	high_impact	2.24	high_impact	0.77	0.85	4.15	10.6	0.32	N	0.88	polymorphism	0.92	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12575	12575	T	C	MI.19738	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	239	80	F	S	tTc/tCc	0.87	0.69	0	probably_damaging	0.97	neutral	0.43	neutral	0.92	deleterious	-5.55	deleterious	-6.84	high_impact	4.12	0.77	neutral	0.41	neutral	4.13	23.80	deleterious	0.14	0.4	NA	NA	0.8	disease	0.71	disease	0.73	disease	5	0.97	neutral	0.23	neutral	2	deleterious	0.84	deleterious	-2.18	low_impact	0.17	medium_impact	2.56	high_impact	0.54	0.8	4.15	10.6	0.36	N	0.97	polymorphism	0.57	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12575	12575	T	G	MI.19739	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	239	80	F	C	tTc/tGc	0.87	0.69	0	probably_damaging	0.99	neutral	0.18	neutral	0.91	deleterious	-6.71	deleterious	-6.66	high_impact	3.77	0.73	neutral	0.4	neutral	3.98	23.60	deleterious	0.19	0.45	NA	NA	0.87	disease	0.74	disease	0.78	disease	6	0.99	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-2.64	low_impact	-0.13	medium_impact	2.24	high_impact	0.53	0.8	4.15	10.6	0.4	N	0.99	disease_causing	0.54	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5947	5947	T	C	MI.1974	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	44	15	I	T	aTt/aCt	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-0.52	deleterious	-5.55	neutral	-1.05	high_impact	4.11	0.67	neutral	0.14	damaging	3.25	22.80	deleterious	0.33	0.55	0.77	disease	0.82	disease	0.68	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.7	high_impact	0.58	0.9	1.17	6.73	0.48	N	0.76	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12576	12576	C	G	MI.19740	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	240	80	F	L	ttC/ttG	7.3	0.98	0	benign	0.12	neutral	0.67	neutral	1.25	neutral	-1.16	deleterious	-4.23	medium_impact	2.02	0.82	neutral	0.9	neutral	2.90	21.90	deleterious	0.46	0.55	NA	NA	0.38	neutral	0.41	neutral	0.17	neutral	7	0.22	neutral	0.78	deleterious	-3	neutral	0.73	deleterious	0.08	medium_impact	0.4	medium_impact	0.64	medium_impact	0.81	0.85	4.15	10.6	0.55	P	0.92	disease_causing	0.8	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12576	12576	C	A	MI.19741	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	240	80	F	L	ttC/ttA	7.3	0.98	0	benign	0.12	neutral	0.67	neutral	1.25	neutral	-1.16	deleterious	-4.23	medium_impact	2.02	0.82	neutral	0.9	neutral	3.22	22.70	deleterious	0.46	0.55	NA	NA	0.38	neutral	0.41	neutral	0.17	neutral	7	0.22	neutral	0.78	deleterious	-3	neutral	0.73	deleterious	0.08	medium_impact	0.4	medium_impact	0.64	medium_impact	0.81	0.85	4.15	10.6	0.56	P	0.92	disease_causing	0.8	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12577	12577	A	C	MI.19742	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	241	81	K	Q	Aaa/Caa	-4.63	0	0	probably_damaging	1	neutral	0.3	neutral	1.46	neutral	-1.7	deleterious	-3.94	medium_impact	2.46	0.73	neutral	0.33	neutral	3.30	22.90	deleterious	0.49	0.55	0.58	disease	0.68	disease	0.58	disease	0.52	disease	0	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.03	medium_impact	1.04	medium_impact	0.61	0.8	28.86	7.16	0.28	N	0.82	polymorphism	0.87	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12577	12577	A	G	MI.19743	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	241	81	K	E	Aaa/Gaa	-4.63	0	0	probably_damaging	1	neutral	0.28	neutral	1.46	neutral	-1.6	deleterious	-3.94	medium_impact	3.42	0.69	neutral	0.26	damaging	3.85	23.40	deleterious	0.4	0.5	0.55	disease	0.82	disease	0.7	disease	0.73	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.01	medium_impact	1.92	medium_impact	0.61	0.8	28.86	7.16	0.3	N	0.84	polymorphism	0.8	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12578	12578	A	T	MI.19744	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	242	81	K	M	aAa/aTa	8.44	1	0	probably_damaging	1	neutral	0.26	neutral	1.43	neutral	-2.71	deleterious	-5.91	medium_impact	2.72	0.73	neutral	0.29	neutral	3.86	23.50	deleterious	0.28	0.45	0.87	disease	0.72	disease	0.59	disease	0.73	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	-0.02	medium_impact	1.28	medium_impact	0.41	0.8	28.86	7.16	0.52	P	0.40	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12578	12578	A	C	MI.19745	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	242	81	K	T	aAa/aCa	8.44	1	0	probably_damaging	1	neutral	0.41	neutral	1.5	neutral	-0.94	deleterious	-5.91	medium_impact	2.15	0.77	neutral	0.26	damaging	3.53	23.10	deleterious	0.24	0.45	0.69	disease	0.68	disease	0.59	disease	0.55	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.15	medium_impact	0.76	medium_impact	0.46	0.8	28.86	7.16	0.46	N	0.75	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12579	12579	A	C	MI.19746	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	243	81	K	N	aaA/aaC	3.85	0.99	0	probably_damaging	1	neutral	0.37	neutral	1.44	neutral	-2.27	deleterious	-4.92	medium_impact	2.58	0.73	neutral	0.3	neutral	3.65	23.20	deleterious	0.58	0.65	0.43	neutral	0.76	disease	0.58	disease	0.62	disease	2	1	deleterious	0.19	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.11	medium_impact	1.15	medium_impact	0.67	0.85	28.86	7.16	0.45	N	0.63	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12579	12579	A	T	MI.19747	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	243	81	K	N	aaA/aaT	3.85	0.99	0	probably_damaging	1	neutral	0.37	neutral	1.44	neutral	-2.27	deleterious	-4.92	medium_impact	2.58	0.73	neutral	0.3	neutral	3.71	23.30	deleterious	0.58	0.65	0.43	neutral	0.76	disease	0.58	disease	0.62	disease	2	1	deleterious	0.19	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.11	medium_impact	1.15	medium_impact	0.67	0.85	28.86	7.16	0.46	N	0.63	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12580	12580	C	A	MI.19748	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	244	82	L	M	Cta/Ata	0.87	0.25	0	possibly_damaging	0.66	neutral	0.33	neutral	1.32	deleterious	-3.07	neutral	-1	low_impact	1.54	0.81	neutral	0.96	neutral	2.35	18.49	deleterious	0.25	0.45	0.31	neutral	0.24	neutral	0.28	neutral	0.44	neutral	1	0.73	neutral	0.34	neutral	-3	neutral	0.68	deleterious	-1.02	low_impact	0.06	medium_impact	0.2	medium_impact	0.91	0.95	19.57	15.46	0.41	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12580	12580	C	G	MI.19749	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	244	82	L	V	Cta/Gta	0.87	0.25	0	possibly_damaging	0.9	neutral	0.49	neutral	1.36	neutral	-0.25	neutral	-2.47	low_impact	1.92	0.81	neutral	0.38	neutral	3.25	22.80	deleterious	0.3	0.45	0.47	neutral	0.44	neutral	0.46	neutral	0.47	neutral	1	0.89	neutral	0.3	neutral	-3	neutral	0.73	deleterious	-1.65	low_impact	0.22	medium_impact	0.55	medium_impact	0.81	0.85	19.57	15.46	0.25	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5947	5947	T	A	MI.1975	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	44	15	I	N	aTt/aAt	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-0.53	deleterious	-7.68	neutral	-1.47	high_impact	4.46	0.62	neutral	0.12	damaging	4.22	23.90	deleterious	0.22	0.55	0.93	disease	0.91	disease	0.7	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.35	0.9	1.17	6.73	0.5	P	0.94	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12581	12581	T	G	MI.19750	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	245	82	L	R	cTa/cGa	-0.96	0	0	probably_damaging	0.99	neutral	0.33	neutral	1.25	deleterious	-4.71	deleterious	-5.18	high_impact	3.67	0.62	neutral	0.14	damaging	4.10	23.70	deleterious	0.1	0.4	0.73	disease	0.88	disease	0.76	disease	0.82	disease	6	0.99	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-2.64	low_impact	0.06	medium_impact	2.15	high_impact	0.49	0.8	19.57	15.46	0.34	N	0.90	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12581	12581	T	A	MI.19751	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	245	82	L	Q	cTa/cAa	-0.96	0	0	probably_damaging	0.99	neutral	0.28	neutral	1.25	deleterious	-4.93	deleterious	-5.02	medium_impact	3.33	0.7	neutral	0.2	damaging	4.26	23.90	deleterious	0.13	0.4	0.74	disease	0.66	disease	0.64	disease	0.72	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.83	deleterious	-2.64	low_impact	0.01	medium_impact	1.84	medium_impact	0.71	0.85	19.57	15.46	0.3	N	0.87	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12581	12581	T	C	MI.19752	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	245	82	L	P	cTa/cCa	-0.96	0	0	probably_damaging	1	neutral	0.22	neutral	1.24	deleterious	-5.29	deleterious	-6.16	high_impact	3.67	0.54	damaging	0.12	damaging	3.85	23.40	deleterious	0.13	0.4	0.81	disease	0.85	disease	0.64	disease	0.79	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.07	medium_impact	2.15	high_impact	0.66	0.8	19.57	15.46	0.27	N	0.95	disease_causing	0.52	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12583	12583	G	T	MI.19753	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	247	83	D	Y	Gac/Tac	-0.73	0.02	0	probably_damaging	1	neutral	1	neutral	-0.38	deleterious	-9.68	deleterious	-8.86	high_impact	4.06	0.35	damaging	0.31	neutral	3.76	23.30	deleterious	0.17	0.45	0.89	disease	0.91	disease	0.88	disease	0.86	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.89	deleterious	-3.6	low_impact	1.89	high_impact	2.51	high_impact	0.40	0.8	27.69	7.06	0.59	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12583	12583	G	A	MI.19754	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	247	83	D	N	Gac/Aac	-0.73	0.02	0	probably_damaging	1	neutral	0.35	neutral	-0.31	deleterious	-5.74	deleterious	-4.92	medium_impact	3.12	0.45	damaging	0.55	neutral	4.05	23.70	deleterious	0.44	0.55	0.23	neutral	0.78	disease	0.86	disease	0.71	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.08	medium_impact	1.65	medium_impact	0.76	0.85	27.69	7.06	0.51	N	0.98	disease_causing	0.98	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12583	12583	G	C	MI.19755	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	247	83	D	H	Gac/Cac	-0.73	0.02	0	probably_damaging	1	neutral	0.54	neutral	-0.38	deleterious	-8.48	deleterious	-6.89	high_impact	4.41	0.4	damaging	0.3	neutral	3.47	23.00	deleterious	0.21	0.45	0.53	disease	0.85	disease	0.91	disease	0.8	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.27	medium_impact	2.83	high_impact	0.61	0.8	27.69	7.06	0.59	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12584	12584	A	G	MI.19756	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	248	83	D	G	gAc/gGc	9.13	1	0	probably_damaging	1	neutral	0.35	neutral	-0.36	deleterious	-7.35	deleterious	-6.89	high_impact	4.41	0.35	damaging	0.41	neutral	3.75	23.30	deleterious	0.21	0.45	0.74	disease	0.85	disease	0.86	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.08	medium_impact	2.83	high_impact	0.48	0.8	27.69	7.06	0.77	P	0.98	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12584	12584	A	T	MI.19757	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	248	83	D	V	gAc/gTc	9.13	1	0	probably_damaging	1	neutral	0.51	neutral	-0.38	deleterious	-9.14	deleterious	-8.86	high_impact	4.41	0.29	damaging	0.36	neutral	3.52	23.10	deleterious	0.17	0.45	0.83	disease	0.91	disease	0.87	disease	0.83	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.24	medium_impact	2.83	high_impact	0.35	0.8	27.69	7.06	0.86	P	0.99	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12584	12584	A	C	MI.19758	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	248	83	D	A	gAc/gCc	9.13	1	0	probably_damaging	1	neutral	0.55	neutral	-0.36	deleterious	-7.37	deleterious	-7.88	high_impact	4.41	0.38	damaging	0.44	neutral	3.45	23.00	deleterious	0.18	0.45	0.67	disease	0.78	disease	0.86	disease	0.8	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.28	medium_impact	2.83	high_impact	0.55	0.8	27.69	7.06	0.75	P	0.94	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12585	12585	C	G	MI.19759	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	249	83	D	E	gaC/gaG	6.61	1	0	probably_damaging	1	neutral	0.32	neutral	-0.31	deleterious	-5.71	deleterious	-3.94	high_impact	4.41	0.36	damaging	0.35	neutral	3.78	23.40	deleterious	0.29	0.45	0.51	disease	0.75	disease	0.84	disease	0.79	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.05	medium_impact	2.83	high_impact	0.41	0.8	27.69	7.06	0.8	P	0.91	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5947	5947	T	G	MI.1976	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	44	15	I	S	aTt/aGt	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-0.53	deleterious	-6.63	neutral	-1.26	high_impact	4.46	0.74	neutral	0.15	damaging	4.12	23.80	deleterious	0.24	0.55	0.87	disease	0.89	disease	0.7	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.43	0.9	1.17	6.73	0.52	P	0.62	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12585	12585	C	A	MI.19760	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	249	83	D	E	gaC/gaA	6.61	1	0	probably_damaging	1	neutral	0.32	neutral	-0.31	deleterious	-5.71	deleterious	-3.94	high_impact	4.41	0.36	damaging	0.35	neutral	3.98	23.60	deleterious	0.29	0.45	0.51	disease	0.75	disease	0.84	disease	0.79	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.05	medium_impact	2.83	high_impact	0.41	0.8	27.69	7.06	0.81	P	0.91	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12586	12586	T	G	MI.19761	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	250	84	Y	D	Tac/Gac	-2.8	0	0	probably_damaging	0.98	neutral	0.24	neutral	1.54	neutral	0.42	deleterious	-8.81	medium_impact	3.02	0.74	neutral	0.14	damaging	3.84	23.40	deleterious	0.38	0.5	0.63	disease	0.73	disease	0.63	disease	0.71	disease	4	0.99	deleterious	0.13	neutral	1	deleterious	0.79	deleterious	-2.35	low_impact	-0.04	medium_impact	1.56	medium_impact	0.34	0.8	8.46	11.1	0.32	N	0.95	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12586	12586	T	A	MI.19762	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	250	84	Y	N	Tac/Aac	-2.8	0	0	probably_damaging	0.98	neutral	0.33	neutral	1.54	neutral	1.03	deleterious	-7.92	medium_impact	2.33	0.8	neutral	0.26	damaging	4.07	23.70	deleterious	0.42	0.55	0.59	disease	0.59	disease	0.52	disease	0.54	disease	1	0.99	deleterious	0.18	neutral	1	deleterious	0.75	deleterious	-2.35	low_impact	0.06	medium_impact	0.93	medium_impact	0.29	0.8	8.46	11.1	0.27	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12586	12586	T	C	MI.19763	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	250	84	Y	H	Tac/Cac	-2.8	0	0	probably_damaging	0.98	neutral	0.54	neutral	1.55	neutral	-0.12	deleterious	-4.31	low_impact	0.92	0.81	neutral	0.85	neutral	1.71	14.49	neutral	0.61	0.65	0.69	disease	0.3	neutral	0.31	neutral	0.62	disease	2	0.98	deleterious	0.28	neutral	-2	neutral	0.74	deleterious	-2.35	low_impact	0.27	medium_impact	-0.36	medium_impact	0.41	0.8	8.46	11.1	0.27	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12587	12587	A	T	MI.19764	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	251	84	Y	F	tAc/tTc	-0.5	0	0	benign	0.12	neutral	0.7	neutral	1.53	neutral	-0.04	deleterious	-2.82	neutral_impact	0.5	0.79	neutral	0.93	neutral	1.76	14.75	neutral	0.49	0.55	0.51	disease	0.36	neutral	0.23	neutral	0.36	neutral	3	0.19	neutral	0.79	deleterious	-6	neutral	0.72	deleterious	0.08	medium_impact	0.44	medium_impact	-0.75	medium_impact	0.46	0.8	8.46	11.1	0.26	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12587	12587	A	C	MI.19765	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	251	84	Y	S	tAc/tCc	-0.5	0	0	probably_damaging	0.95	neutral	0.44	neutral	1.69	neutral	1.87	deleterious	-7.81	low_impact	1.7	0.78	neutral	0.47	neutral	2.47	19.31	deleterious	0.32	0.5	0.44	neutral	0.44	neutral	0.52	disease	0.48	neutral	0	0.95	neutral	0.25	neutral	-2	neutral	0.72	deleterious	-1.96	low_impact	0.18	medium_impact	0.35	medium_impact	0.23	0.8	8.46	11.1	0.33	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12587	12587	A	G	MI.19766	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	251	84	Y	C	tAc/tGc	-0.5	0	0	probably_damaging	0.99	neutral	0.18	neutral	1.5	neutral	-2.73	deleterious	-7.86	medium_impact	2.47	0.72	neutral	0.3	neutral	3.42	23.00	deleterious	0.32	0.5	0.76	disease	0.71	disease	0.38	neutral	0.56	disease	1	0.99	deleterious	0.1	neutral	1	deleterious	0.77	deleterious	-2.64	low_impact	-0.13	medium_impact	1.05	medium_impact	0.15	0.8	8.46	11.1	0.35	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12589	12589	T	G	MI.19767	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	253	85	F	V	Ttc/Gtc	-5.32	0	0	possibly_damaging	0.73	neutral	0.53	neutral	1.66	neutral	-0.93	deleterious	-6.82	medium_impact	2.44	0.74	neutral	0.57	neutral	4.02	23.60	deleterious	0.33	0.5	0.41	neutral	0.8	disease	0.69	disease	0.77	disease	5	0.7	neutral	0.4	neutral	0	NA	0.73	deleterious	-1.16	low_impact	0.26	medium_impact	1.03	medium_impact	0.66	0.8	4.15	8.81	0.28	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12589	12589	T	A	MI.19768	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	253	85	F	I	Ttc/Atc	-5.32	0	0	possibly_damaging	0.73	neutral	0.38	neutral	1.6	neutral	0.04	deleterious	-5.84	medium_impact	2.23	0.73	neutral	0.58	neutral	4.41	24.10	deleterious	0.27	0.45	0.45	neutral	0.75	disease	0.67	disease	0.7	disease	4	0.75	neutral	0.33	neutral	0	NA	0.75	deleterious	-1.16	low_impact	0.12	medium_impact	0.83	medium_impact	0.64	0.8	4.15	8.81	0.3	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12589	12589	T	C	MI.19769	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	253	85	F	L	Ttc/Ctc	-5.32	0	0	benign	0.08	neutral	0.71	neutral	1.96	neutral	2.47	deleterious	-5.82	low_impact	1.22	0.78	neutral	0.72	neutral	4.00	23.60	deleterious	0.42	0.55	0.39	neutral	0.55	disease	0.62	disease	0.5	neutral	0	0.2	neutral	0.82	deleterious	-6	neutral	0.70	deleterious	0.26	medium_impact	0.45	medium_impact	-0.09	medium_impact	0.80	0.85	4.15	8.81	0.27	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5948	5948	T	A	MI.1977	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	45	15	I	M	atT/atA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	-0.51	deleterious	-5.27	neutral	-0.62	high_impact	4.46	0.7	neutral	0.15	damaging	3.49	23.10	deleterious	0.26	0.55	0.73	disease	0.76	disease	0.55	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.82	0.9	1.17	6.73	0.52	P	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12590	12590	T	A	MI.19770	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	254	85	F	Y	tTc/tAc	4.54	0.99	0	benign	0.12	neutral	0.79	neutral	1.6	neutral	-1.51	deleterious	-2.94	neutral_impact	-0.46	0.71	neutral	0.77	neutral	1.71	14.45	neutral	0.3	0.45	0.37	neutral	0.13	neutral	0.27	neutral	0.21	neutral	6	0.1	neutral	0.84	deleterious	-6	neutral	0.68	deleterious	0.08	medium_impact	0.55	medium_impact	-1.62	low_impact	0.67	0.85	4.15	8.81	0.44	N	0.88	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12590	12590	T	G	MI.19771	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	254	85	F	C	tTc/tGc	4.54	0.99	0	probably_damaging	0.98	neutral	0.14	neutral	1.49	deleterious	-3.9	deleterious	-7.81	medium_impact	2.78	0.68	neutral	0.47	neutral	3.95	23.60	deleterious	0.23	0.45	0.76	disease	0.82	disease	0.7	disease	0.78	disease	6	0.99	deleterious	0.08	neutral	1	deleterious	0.80	deleterious	-2.35	low_impact	-0.2	medium_impact	1.34	medium_impact	0.49	0.8	4.15	8.81	0.42	N	0.99	polymorphism	0.89	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12590	12590	T	C	MI.19772	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	254	85	F	S	tTc/tCc	4.54	0.99	0	probably_damaging	0.94	neutral	0.5	neutral	1.51	neutral	-2.4	deleterious	-7.82	medium_impact	2.58	0.69	neutral	0.49	neutral	4.06	23.70	deleterious	0.25	0.45	0.51	disease	0.74	disease	0.67	disease	0.73	disease	5	0.93	neutral	0.28	neutral	1	deleterious	0.78	deleterious	-1.88	low_impact	0.23	medium_impact	1.15	medium_impact	0.55	0.8	4.15	8.81	0.45	N	0.97	polymorphism	0.93	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12591	12591	C	G	MI.19773	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	255	85	F	L	ttC/ttG	3.17	0.99	0	benign	0.08	neutral	0.71	neutral	1.96	neutral	2.47	deleterious	-5.82	low_impact	1.22	0.78	neutral	0.72	neutral	4.20	23.90	deleterious	0.42	0.55	0.39	neutral	0.55	disease	0.62	disease	0.5	neutral	0	0.2	neutral	0.82	deleterious	-6	neutral	0.70	deleterious	0.26	medium_impact	0.45	medium_impact	-0.09	medium_impact	0.80	0.85	4.15	8.81	0.34	N	0.92	polymorphism	0.97	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12591	12591	C	A	MI.19774	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	255	85	F	L	ttC/ttA	3.17	0.99	0	benign	0.08	neutral	0.71	neutral	1.96	neutral	2.47	deleterious	-5.82	low_impact	1.22	0.78	neutral	0.72	neutral	4.45	24.20	deleterious	0.42	0.55	0.39	neutral	0.55	disease	0.62	disease	0.5	neutral	0	0.2	neutral	0.82	deleterious	-6	neutral	0.70	deleterious	0.26	medium_impact	0.45	medium_impact	-0.09	medium_impact	0.80	0.85	4.15	8.81	0.34	N	0.92	polymorphism	0.97	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12592	12592	T	G	MI.19775	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	256	86	S	A	Tcc/Gcc	-0.73	0.18	0	probably_damaging	1	neutral	0.69	neutral	1.27	neutral	-1.63	deleterious	-2.78	medium_impact	2.7	0.73	neutral	0.31	neutral	3.43	23.00	deleterious	0.29	0.45	0.41	neutral	0.51	disease	0.52	disease	0.45	neutral	1	1	deleterious	0.35	neutral	1	deleterious	0.70	deleterious	-3.6	low_impact	0.42	medium_impact	1.26	medium_impact	0.86	0.9	4.31	7.84	0.22	N	0.49	polymorphism	0.94	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12592	12592	T	C	MI.19776	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	256	86	S	P	Tcc/Ccc	-0.73	0.18	0	probably_damaging	1	neutral	0.28	neutral	1.11	deleterious	-5.07	deleterious	-4.82	high_impact	3.7	0.72	neutral	0.14	damaging	3.78	23.40	deleterious	0.18	0.45	0.87	disease	0.86	disease	0.83	disease	0.85	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.01	medium_impact	2.18	high_impact	0.75	0.85	4.31	7.84	0.43	N	0.98	disease_causing	0.59	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12592	12592	T	A	MI.19777	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	256	86	S	T	Tcc/Acc	-0.73	0.18	0	probably_damaging	1	neutral	0.55	neutral	1.53	neutral	-0.22	deleterious	-2.86	medium_impact	2.13	0.65	neutral	0.22	damaging	3.55	23.10	deleterious	0.23	0.45	0.7	disease	0.43	neutral	0.63	disease	0.6	disease	2	1	deleterious	0.28	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.28	medium_impact	0.74	medium_impact	0.88	0.9	4.31	7.84	0.22	N	0.71	polymorphism	0.81	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12593	12593	C	A	MI.19778	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	257	86	S	Y	tCc/tAc	2.71	0.97	0	probably_damaging	1	neutral	1	neutral	1.11	deleterious	-5.37	deleterious	-5.76	high_impact	4.25	0.74	neutral	0.14	damaging	3.92	23.50	deleterious	0.16	0.45	0.93	disease	0.86	disease	0.76	disease	0.85	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.86	deleterious	-3.6	low_impact	1.89	high_impact	2.68	high_impact	0.81	0.85	4.31	7.84	0.43	N	0.99	disease_causing	0.99	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12593	12593	C	T	MI.19779	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	257	86	S	F	tCc/tTc	2.71	0.97	0	probably_damaging	1	neutral	0.79	neutral	1.19	neutral	-2.58	deleterious	-5.76	medium_impact	2.97	0.69	neutral	0.11	damaging	4.10	23.70	deleterious	0.15	0.4	0.93	disease	0.88	disease	0.75	disease	0.84	disease	7	1	deleterious	0.4	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.55	medium_impact	1.51	medium_impact	0.45	0.8	4.31	7.84	0.32	N	0.99	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5948	5948	T	G	MI.1978	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	45	15	I	M	atT/atG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	-0.51	deleterious	-5.27	neutral	-0.62	high_impact	4.46	0.7	neutral	0.15	damaging	3.25	22.80	deleterious	0.26	0.55	0.73	disease	0.76	disease	0.55	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.82	0.9	1.17	6.73	0.5	P	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12593	12593	C	G	MI.19780	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	257	86	S	C	tCc/tGc	2.71	0.97	0	probably_damaging	1	neutral	0.19	neutral	1.1	deleterious	-5.6	deleterious	-4.58	high_impact	3.9	0.71	neutral	0.16	damaging	3.38	23.00	deleterious	0.23	0.45	0.92	disease	0.82	disease	0.66	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.12	medium_impact	2.36	high_impact	0.65	0.8	4.31	7.84	0.44	N	0.99	disease_causing	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12595	12595	A	T	MI.19781	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	259	87	M	L	Ata/Tta	-6.47	0	0	benign	0.12	neutral	0.84	neutral	1.79	neutral	1.44	neutral	-0.34	neutral_impact	-0.24	0.84	neutral	0.97	neutral	-0.53	0.19	neutral	0.55	0.6	0.38	neutral	0.42	neutral	0.4	neutral	0.45	neutral	1	0.07	neutral	0.86	deleterious	-6	neutral	0.16	neutral	0.08	medium_impact	0.63	medium_impact	-1.42	low_impact	0.51	0.8	18.91	14.09	0.32	N	0.53	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12595	12595	A	C	MI.19782	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	259	87	M	L	Ata/Cta	-6.47	0	0	benign	0.12	neutral	0.84	neutral	1.79	neutral	1.44	neutral	-0.34	neutral_impact	-0.24	0.84	neutral	0.97	neutral	-0.66	0.09	neutral	0.55	0.6	0.38	neutral	0.42	neutral	0.4	neutral	0.45	neutral	1	0.07	neutral	0.86	deleterious	-6	neutral	0.16	neutral	0.08	medium_impact	0.63	medium_impact	-1.42	low_impact	0.51	0.8	18.91	14.09	0.31	N	0.53	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12595	12595	A	G	MI.19783	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	259	87	M	V	Ata/Gta	-6.47	0	0	benign	0.01	neutral	0.55	neutral	1.66	neutral	0.87	neutral	-1.05	low_impact	0.9	0.87	neutral	0.99	neutral	-0.50	0.22	neutral	0.61	0.65	0.21	neutral	0.47	neutral	0.44	neutral	0.44	neutral	1	0.43	neutral	0.77	deleterious	-6	neutral	0.12	neutral	1.15	medium_impact	0.28	medium_impact	-0.38	medium_impact	0.51	0.8	18.91	14.09	0.28	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12596	12596	T	A	MI.19784	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	260	87	M	K	aTa/aAa	-1.19	0	0	possibly_damaging	0.81	neutral	0.26	neutral	1.5	neutral	-1.87	deleterious	-4.38	medium_impact	2.83	0.75	neutral	0.48	neutral	2.21	17.57	deleterious	0.28	0.45	0.73	disease	0.82	disease	0.7	disease	0.79	disease	6	0.86	neutral	0.23	neutral	0	NA	0.59	deleterious	-1.34	low_impact	-0.02	medium_impact	1.38	medium_impact	0.60	0.8	18.91	14.09	0.3	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12596	12596	T	C	MI.19785	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	260	87	M	T	aTa/aCa	-1.19	0	0	possibly_damaging	0.48	neutral	0.43	neutral	1.56	neutral	-1.06	deleterious	-3.36	low_impact	1.19	0.86	neutral	0.98	neutral	-0.07	1.98	neutral	0.47	0.55	0.19	neutral	0.45	neutral	0.45	neutral	0.44	neutral	1	0.54	neutral	0.48	deleterious	-3	neutral	0.33	neutral	-0.71	medium_impact	0.17	medium_impact	-0.12	medium_impact	0.50	0.8	18.91	14.09	0.34	N	0.81	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12597	12597	A	T	MI.19786	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	261	87	M	I	atA/atT	2.94	0.12	0	benign	0.04	neutral	0.54	neutral	1.62	neutral	0.16	neutral	-0.69	neutral_impact	-0.64	0.83	neutral	0.97	neutral	-1.25	0.01	neutral	0.57	0.65	0.24	neutral	0.29	neutral	0.34	neutral	0.42	neutral	2	0.41	neutral	0.75	deleterious	-6	neutral	0.15	neutral	0.57	medium_impact	0.27	medium_impact	-1.79	low_impact	0.61	0.8	18.91	14.09	0.36	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12597	12597	A	C	MI.19787	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	261	87	M	I	atA/atC	2.94	0.12	0	benign	0.04	neutral	0.54	neutral	1.62	neutral	0.16	neutral	-0.69	neutral_impact	-0.64	0.83	neutral	0.97	neutral	-1.31	0.00	neutral	0.57	0.65	0.24	neutral	0.29	neutral	0.34	neutral	0.42	neutral	2	0.41	neutral	0.75	deleterious	-6	neutral	0.15	neutral	0.57	medium_impact	0.27	medium_impact	-1.79	low_impact	0.61	0.8	18.91	14.09	0.35	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12598	12598	A	C	MI.19788	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	262	88	M	L	Ata/Cta	-6.7	0	0	benign	0.01	neutral	0.73	neutral	1.64	neutral	1.81	neutral	0.03	neutral_impact	-0.13	0.86	neutral	0.97	neutral	-0.13	1.54	neutral	0.48	0.55	0.3	neutral	0.54	disease	0.47	neutral	0.46	neutral	1	0.25	neutral	0.86	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.47	medium_impact	-1.32	low_impact	0.48	0.8	16.75	14.26	0.28	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12598	12598	A	T	MI.19789	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	262	88	M	L	Ata/Tta	-6.7	0	0	benign	0.01	neutral	0.73	neutral	1.64	neutral	1.81	neutral	0.03	neutral_impact	-0.13	0.86	neutral	0.97	neutral	-0.06	2.07	deleterious	0.48	0.55	0.3	neutral	0.54	disease	0.47	neutral	0.46	neutral	1	0.25	neutral	0.86	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.47	medium_impact	-1.32	low_impact	0.48	0.8	16.75	14.26	0.29	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5949	5949	G	C	MI.1979	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	46	16	G	R	Gga/Cga	-4.27	0	0	probably_damaging	1	deleterious	0	neutral	2.7	deleterious	-6.46	neutral	-1.77	high_impact	4.84	0.7	neutral	0.09	damaging	3.75	23.30	deleterious	0.15	0.55	0.87	disease	0.92	disease	0.77	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.60	0.9	4.09	7.65	0.7	P	0.95	disease_causing	0.97	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12598	12598	A	G	MI.19790	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	262	88	M	V	Ata/Gta	-6.7	0	0	benign	0.12	neutral	0.56	neutral	1.59	neutral	0.82	neutral	-0.39	neutral_impact	0.62	0.85	neutral	0.96	neutral	-0.52	0.19	neutral	0.57	0.65	0.4	neutral	0.51	disease	0.49	neutral	0.46	neutral	1	0.34	neutral	0.72	deleterious	-6	neutral	0.19	neutral	0.08	medium_impact	0.29	medium_impact	-0.64	medium_impact	0.50	0.8	16.75	14.26	0.27	N	0.22	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12599	12599	T	C	MI.19791	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	263	88	M	T	aTa/aCa	0.41	0	0	benign	0.01	neutral	0.42	neutral	1.6	neutral	0	neutral	-2.35	neutral_impact	0.3	0.85	neutral	0.99	neutral	-0.25	0.87	neutral	0.48	0.55	0.43	neutral	0.46	neutral	0.49	neutral	0.47	neutral	1	0.57	neutral	0.71	deleterious	-6	neutral	0.18	neutral	1.15	medium_impact	0.16	medium_impact	-0.93	medium_impact	0.39	0.8	16.75	14.26	0.34	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12599	12599	T	A	MI.19792	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	263	88	M	K	aTa/aAa	0.41	0	0	benign	0.26	neutral	0.3	neutral	1.47	neutral	-2.94	deleterious	-3.95	medium_impact	2.78	0.72	neutral	0.46	neutral	2.16	17.27	deleterious	0.23	0.45	0.52	disease	0.85	disease	0.72	disease	0.8	disease	6	0.64	neutral	0.52	deleterious	-3	neutral	0.41	neutral	-0.32	medium_impact	0.03	medium_impact	1.34	medium_impact	0.45	0.8	16.75	14.26	0.31	N	0.55	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12600	12600	A	C	MI.19793	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	264	88	M	I	atA/atC	1.1	0	0	benign	0.18	neutral	0.47	neutral	1.76	neutral	0.73	neutral	-0.06	neutral_impact	-0.58	0.84	neutral	0.98	neutral	-1.35	0.00	neutral	0.52	0.6	0.31	neutral	0.29	neutral	0.41	neutral	0.44	neutral	1	0.44	neutral	0.65	deleterious	-6	neutral	0.21	neutral	-0.12	medium_impact	0.2	medium_impact	-1.73	low_impact	0.62	0.8	16.75	14.26	0.34	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12600	12600	A	T	MI.19794	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	264	88	M	I	atA/atT	1.1	0	0	benign	0.18	neutral	0.47	neutral	1.76	neutral	0.73	neutral	-0.06	neutral_impact	-0.58	0.84	neutral	0.98	neutral	-1.29	0.01	neutral	0.52	0.6	0.31	neutral	0.29	neutral	0.41	neutral	0.44	neutral	1	0.44	neutral	0.65	deleterious	-6	neutral	0.21	neutral	-0.12	medium_impact	0.2	medium_impact	-1.73	low_impact	0.62	0.8	16.75	14.26	0.34	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12601	12601	T	C	MI.19795	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	265	89	F	L	Ttc/Ctc	-2.34	0	0	probably_damaging	1	neutral	0.74	neutral	1.2	neutral	-1.66	deleterious	-5.91	high_impact	3.86	0.5	damaging	0.5	neutral	3.90	23.50	deleterious	0.39	0.5	0.71	disease	0.85	disease	0.67	disease	0.67	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.48	medium_impact	2.32	high_impact	0.78	0.85	27.53	7.08	0.38	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12601	12601	T	A	MI.19796	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	265	89	F	I	Ttc/Atc	-2.34	0	0	probably_damaging	1	neutral	0.56	neutral	1.05	deleterious	-3.22	deleterious	-5.91	high_impact	4.41	0.54	damaging	0.54	neutral	4.24	23.90	deleterious	0.23	0.45	0.78	disease	0.91	disease	0.72	disease	0.78	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.29	medium_impact	2.83	high_impact	0.65	0.8	27.53	7.08	0.44	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12601	12601	T	G	MI.19797	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	265	89	F	V	Ttc/Gtc	-2.34	0	0	probably_damaging	1	neutral	0.71	neutral	1.08	neutral	-2.84	deleterious	-6.89	high_impact	4.06	0.55	damaging	0.48	neutral	3.92	23.50	deleterious	0.23	0.45	0.74	disease	0.92	disease	0.73	disease	0.79	disease	6	1	deleterious	0.36	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.45	medium_impact	2.51	high_impact	0.59	0.8	27.53	7.08	0.33	N	0.95	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12602	12602	T	G	MI.19798	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	266	89	F	C	tTc/tGc	7.3	1	0	probably_damaging	1	neutral	0.17	neutral	0.98	deleterious	-6.79	deleterious	-7.88	high_impact	4.41	0.56	damaging	0.46	neutral	3.93	23.50	deleterious	0.19	0.45	0.91	disease	0.91	disease	0.75	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.15	medium_impact	2.83	high_impact	0.30	0.8	27.53	7.08	0.57	P	0.99	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12602	12602	T	A	MI.19799	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	266	89	F	Y	tTc/tAc	7.3	1	0	probably_damaging	1	neutral	1	neutral	0.99	deleterious	-5.34	deleterious	-2.95	high_impact	4.41	0.57	damaging	0.44	neutral	4.22	23.90	deleterious	0.22	0.45	0.76	disease	0.85	disease	0.69	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.81	deleterious	-3.6	low_impact	1.89	high_impact	2.83	high_impact	0.68	0.85	27.53	7.08	0.58	P	0.88	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8619	8619	C	A	MI.198	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	93	31	I	M	atC/atA	0.59	0	0	benign	0.38	neutral	0.08	neutral	4.31	neutral	-1.22	neutral	-0.51	low_impact	1.11	0.94	neutral	0.77	neutral	0.97	10.49	neutral	0.57	0.65	0.62	disease	0.29	neutral	0.2	neutral	0.56	disease	1	0.91	neutral	0.35	neutral	-6	neutral	0.36	neutral	-0.55	medium_impact	-0.31	medium_impact	-0.15	medium_impact	0.40	0.9	28.32	22.32	0.47	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5949	5949	G	T	MI.1980	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	46	16	G	W	Gga/Tga	-4.27	0	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-9.44	neutral	-1.76	high_impact	4.49	0.69	neutral	0.11	damaging	4.23	23.90	deleterious	0.13	0.55	0.97	disease	0.93	disease	0.73	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.05	high_impact	0.34	0.9	4.09	7.65	0.43	N	0.83	disease_causing	0.98	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12602	12602	T	C	MI.19800	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	266	89	F	S	tTc/tCc	7.3	1	0	probably_damaging	1	neutral	0.54	neutral	0.98	deleterious	-5.9	deleterious	-7.88	high_impact	4.41	0.56	damaging	0.48	neutral	4.16	23.80	deleterious	0.19	0.45	0.73	disease	0.89	disease	0.71	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.27	medium_impact	2.83	high_impact	0.51	0.8	27.53	7.08	0.57	P	0.97	disease_causing	1	0.15	.	.	.	.	.	.	COSM1497296	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12603	12603	C	A	MI.19801	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	267	89	F	L	ttC/ttA	7.3	1	0	probably_damaging	1	neutral	0.74	neutral	1.2	neutral	-1.66	deleterious	-5.91	high_impact	3.86	0.5	damaging	0.5	neutral	4.51	24.30	deleterious	0.39	0.5	0.71	disease	0.85	disease	0.67	disease	0.67	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.48	medium_impact	2.32	high_impact	0.78	0.85	27.53	7.08	0.6	P	0.92	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12603	12603	C	G	MI.19802	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	267	89	F	L	ttC/ttG	7.3	1	0	probably_damaging	1	neutral	0.74	neutral	1.2	neutral	-1.66	deleterious	-5.91	high_impact	3.86	0.5	damaging	0.5	neutral	4.17	23.80	deleterious	0.39	0.5	0.71	disease	0.85	disease	0.67	disease	0.67	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.48	medium_impact	2.32	high_impact	0.78	0.85	27.53	7.08	0.6	P	0.92	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12604	12604	A	G	MI.19803	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	268	90	I	V	Atc/Gtc	-3.49	0	0	benign	0.13	neutral	0.44	neutral	1.56	neutral	-0.27	neutral	-0.08	neutral_impact	0.73	0.85	neutral	0.97	neutral	-1.23	0.01	neutral	0.66	0.7	0.37	neutral	0.22	neutral	0.31	neutral	0.4	neutral	2	0.48	neutral	0.66	deleterious	-6	neutral	0.18	neutral	0.04	medium_impact	0.18	medium_impact	-0.54	medium_impact	0.48	0.8	23.38	17.09	0.39	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12604	12604	A	T	MI.19804	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	268	90	I	F	Atc/Ttc	-3.49	0	0	benign	0.37	neutral	0.86	neutral	1.5	neutral	-1.07	neutral	-2.35	low_impact	1.6	0.73	neutral	0.85	neutral	1.93	15.75	deleterious	0.39	0.5	0.47	neutral	0.51	disease	0.4	neutral	0.47	neutral	1	0.26	neutral	0.75	deleterious	-6	neutral	0.50	deleterious	-0.53	medium_impact	0.67	medium_impact	0.26	medium_impact	0.70	0.85	23.38	17.09	0.26	N	0.43	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12604	12604	A	C	MI.19805	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	268	90	I	L	Atc/Ctc	-3.49	0	0	benign	0.01	neutral	1	neutral	1.96	neutral	1.92	neutral	-0.41	neutral_impact	0.03	0.82	neutral	0.93	neutral	0.03	2.83	deleterious	0.36	0.5	0.36	neutral	0.24	neutral	0.3	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	1.89	high_impact	-1.18	low_impact	0.71	0.85	23.38	17.09	0.29	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12605	12605	T	G	MI.19806	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	269	90	I	S	aTc/aGc	-1.65	0	0	benign	0.27	neutral	0.35	neutral	1.51	neutral	-0.94	deleterious	-3.24	low_impact	1.7	0.8	neutral	0.67	neutral	2.37	18.63	deleterious	0.34	0.5	0.34	neutral	0.63	disease	0.5	neutral	0.48	neutral	0	0.58	neutral	0.54	deleterious	-6	neutral	0.41	neutral	-0.34	medium_impact	0.08	medium_impact	0.35	medium_impact	0.54	0.8	23.38	17.09	0.33	N	0.54	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12605	12605	T	A	MI.19807	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	269	90	I	N	aTc/aAc	-1.65	0	0	possibly_damaging	0.46	neutral	0.2	neutral	1.44	deleterious	-3.13	deleterious	-4.22	medium_impact	3.02	0.75	neutral	0.44	neutral	4.01	23.60	deleterious	0.3	0.45	0.64	disease	0.72	disease	0.6	disease	0.71	disease	4	0.77	neutral	0.37	neutral	0	NA	0.64	deleterious	-0.68	medium_impact	-0.1	medium_impact	1.56	medium_impact	0.51	0.8	23.38	17.09	0.33	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12605	12605	T	C	MI.19808	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	269	90	I	T	aTc/aCc	-1.65	0	0	benign	0.02	neutral	0.56	neutral	1.56	neutral	-0.24	neutral	-2.2	neutral_impact	0.16	0.88	neutral	0.96	neutral	-1.11	0.01	neutral	0.53	0.6	0.31	neutral	0.14	neutral	0.32	neutral	0.24	neutral	5	0.42	neutral	0.77	deleterious	-6	neutral	0.10	neutral	0.86	medium_impact	0.29	medium_impact	-1.06	low_impact	0.62	0.8	23.38	17.09	0.38	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12606	12606	C	A	MI.19809	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	270	90	I	M	atC/atA	0.87	0	0	benign	0.05	neutral	0.62	neutral	1.54	neutral	-0.55	neutral	0.43	neutral_impact	0.28	0.88	neutral	0.98	neutral	1.52	13.40	neutral	0.51	0.6	0.6	disease	0.19	neutral	0.3	neutral	0.47	neutral	1	0.31	neutral	0.79	deleterious	-6	neutral	0.55	deleterious	0.47	medium_impact	0.35	medium_impact	-0.95	medium_impact	0.76	0.85	23.38	17.09	0.33	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5950	5950	G	C	MI.1981	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	47	16	G	A	gGa/gCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.97	neutral	-2.1	neutral	-1.32	medium_impact	3.42	0.79	neutral	0.15	damaging	2.88	21.80	deleterious	0.25	0.55	0.28	neutral	0.71	disease	0.39	neutral	0.53	disease	1	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.06	high_impact	0.64	0.9	4.09	7.65	0.46	N	0.64	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12606	12606	C	G	MI.19810	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	270	90	I	M	atC/atG	0.87	0	0	benign	0.05	neutral	0.62	neutral	1.54	neutral	-0.55	neutral	0.43	neutral_impact	0.28	0.88	neutral	0.98	neutral	1.07	11.08	neutral	0.51	0.6	0.6	disease	0.19	neutral	0.3	neutral	0.47	neutral	1	0.31	neutral	0.79	deleterious	-6	neutral	0.55	deleterious	0.47	medium_impact	0.35	medium_impact	-0.95	medium_impact	0.76	0.85	23.38	17.09	0.33	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12607	12607	C	T	MI.19811	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	271	91	P	S	Cct/Tct	-5.55	0	0	probably_damaging	1	neutral	0.4	neutral	1.66	neutral	0.81	deleterious	-5.89	low_impact	1.5	0.72	neutral	0.81	neutral	2.62	20.30	deleterious	0.42	0.55	0.41	neutral	0.8	disease	0.44	neutral	0.52	disease	0	1	deleterious	0.2	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.14	medium_impact	0.17	medium_impact	0.30	0.8	7.13	11.76	0.31	N	0.31	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12607	12607	C	G	MI.19812	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	271	91	P	A	Cct/Gct	-5.55	0	0	probably_damaging	1	neutral	0.51	neutral	1.55	neutral	-0.62	deleterious	-6.35	medium_impact	3.35	0.66	neutral	0.16	damaging	2.90	21.90	deleterious	0.29	0.45	0.48	neutral	0.76	disease	0.6	disease	0.62	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.24	medium_impact	1.86	medium_impact	0.77	0.85	7.13	11.76	0.24	N	0.64	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12607	12607	C	A	MI.19813	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	271	91	P	T	Cct/Act	-5.55	0	0	probably_damaging	1	neutral	0.39	neutral	1.53	neutral	-0.97	deleterious	-6.35	medium_impact	2.87	0.69	neutral	0.21	damaging	3.52	23.10	deleterious	0.33	0.5	0.28	neutral	0.82	disease	0.55	disease	0.64	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.13	medium_impact	1.42	medium_impact	0.77	0.85	7.13	11.76	0.26	N	0.67	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12608	12608	C	A	MI.19814	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	272	91	P	H	cCt/cAt	0.41	0.01	0	probably_damaging	1	neutral	0.54	neutral	1.49	neutral	-2.83	deleterious	-7.49	high_impact	4.16	0.68	neutral	0.13	damaging	3.80	23.40	deleterious	0.25	0.45	0.77	disease	0.9	disease	0.71	disease	0.78	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.27	medium_impact	2.6	high_impact	0.71	0.85	7.13	11.76	0.31	N	0.90	disease_causing	0.63	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12608	12608	C	G	MI.19815	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	272	91	P	R	cCt/cGt	0.41	0.01	0	probably_damaging	1	neutral	0.35	neutral	1.5	neutral	-2.25	deleterious	-7.49	high_impact	4.16	0.69	neutral	0.14	damaging	3.44	23.00	deleterious	0.22	0.45	0.69	disease	0.95	disease	0.73	disease	0.87	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.08	medium_impact	2.6	high_impact	0.74	0.85	7.13	11.76	0.38	N	0.95	disease_causing	0.76	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12608	12608	C	T	MI.19816	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	272	91	P	L	cCt/cTt	0.41	0.01	0	probably_damaging	1	neutral	0.65	neutral	1.67	neutral	0.85	deleterious	-8.47	medium_impact	2.74	0.64	neutral	0.12	damaging	4.15	23.80	deleterious	0.35	0.5	0.35	neutral	0.91	disease	0.62	disease	0.69	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.38	medium_impact	1.3	medium_impact	0.83	0.85	7.13	11.76	0.26	N	0.97	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12610	12610	G	T	MI.19817	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	274	92	V	L	Gta/Tta	-16.1	0	0	benign	0.4	neutral	0.84	neutral	1.27	neutral	0.41	deleterious	-2.66	medium_impact	2.69	0.69	neutral	0.54	neutral	1.72	14.51	neutral	0.41	0.5	0.46	neutral	0.81	disease	0.55	disease	0.67	disease	3	0.29	neutral	0.72	deleterious	-3	neutral	0.28	neutral	-0.58	medium_impact	0.63	medium_impact	1.25	medium_impact	0.65	0.8	13.76	12.87	0.24	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12610	12610	G	A	MI.19818	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	274	92	V	M	Gta/Ata	-16.1	0	0	probably_damaging	0.93	neutral	0.29	neutral	1.05	neutral	-2.69	deleterious	-2.77	medium_impact	2.87	0.78	neutral	0.59	neutral	3.46	23.00	deleterious	0.37	0.5	0.67	disease	0.75	disease	0.61	disease	0.7	disease	4	0.94	neutral	0.18	neutral	1	deleterious	0.69	deleterious	-1.81	low_impact	0.02	medium_impact	1.42	medium_impact	0.76	0.85	13.76	12.87	0.26	N	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12610	12610	G	C	MI.19819	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	274	92	V	L	Gta/Cta	-16.1	0	0	benign	0.4	neutral	0.84	neutral	1.27	neutral	0.41	deleterious	-2.66	medium_impact	2.69	0.69	neutral	0.54	neutral	1.63	14.00	neutral	0.41	0.5	0.46	neutral	0.81	disease	0.55	disease	0.67	disease	3	0.29	neutral	0.72	deleterious	-3	neutral	0.28	neutral	-0.58	medium_impact	0.63	medium_impact	1.25	medium_impact	0.65	0.8	13.76	12.87	0.24	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5950	5950	G	A	MI.1982	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	47	16	G	E	gGa/gAa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.7	deleterious	-5.92	neutral	-1.76	high_impact	4.84	0.66	neutral	0.1	damaging	3.71	23.30	deleterious	0.17	0.55	0.83	disease	0.9	disease	0.76	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.52	0.9	4.09	7.65	0.73	P	0.93	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12611	12611	T	C	MI.19820	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	275	92	V	A	gTa/gCa	-0.04	0	0	possibly_damaging	0.53	neutral	0.2	neutral	1.07	neutral	-2.71	deleterious	-3.8	medium_impact	2.69	0.68	neutral	0.63	neutral	1.73	14.59	neutral	0.27	0.45	0.27	neutral	0.71	disease	0.6	disease	0.66	disease	3	0.79	neutral	0.34	neutral	0	NA	0.37	neutral	-0.8	medium_impact	-0.1	medium_impact	1.25	medium_impact	0.45	0.8	13.76	12.87	0.4	N	0.80	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12611	12611	T	A	MI.19821	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	275	92	V	E	gTa/gAa	-0.04	0	0	possibly_damaging	0.88	neutral	0.13	neutral	1.03	deleterious	-5.27	deleterious	-5.73	high_impact	3.85	0.63	neutral	0.46	neutral	4.24	23.90	deleterious	0.11	0.4	0.71	disease	0.92	disease	0.72	disease	0.8	disease	6	0.95	neutral	0.13	neutral	1	deleterious	0.76	deleterious	-1.57	low_impact	-0.22	medium_impact	2.31	high_impact	0.56	0.8	13.76	12.87	0.37	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12611	12611	T	G	MI.19822	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	275	92	V	G	gTa/gGa	-0.04	0	0	possibly_damaging	0.82	neutral	0.1	neutral	1.03	deleterious	-4.8	deleterious	-6.71	high_impact	3.85	0.64	neutral	0.56	neutral	3.39	23.00	deleterious	0.16	0.45	0.76	disease	0.87	disease	0.62	disease	0.73	disease	5	0.94	neutral	0.14	neutral	1	deleterious	0.65	deleterious	-1.37	low_impact	-0.29	medium_impact	2.31	high_impact	0.56	0.8	13.76	12.87	0.39	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12613	12613	G	T	MI.19823	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	277	93	A	S	Gca/Tca	-2.11	0	0	probably_damaging	1	neutral	0.44	neutral	1.4	neutral	-2.05	deleterious	-2.94	high_impact	3.64	0.7	neutral	0.68	neutral	3.51	23.10	deleterious	0.35	0.5	0.55	disease	0.79	disease	0.59	disease	0.64	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.18	medium_impact	2.12	high_impact	0.77	0.85	23.88	7.03	0.33	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12613	12613	G	C	MI.19824	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	277	93	A	P	Gca/Cca	-2.11	0	0	probably_damaging	1	neutral	0.23	neutral	1.35	deleterious	-4.13	deleterious	-4.92	high_impact	4.34	0.68	neutral	0.34	neutral	3.65	23.20	deleterious	0.15	0.45	0.8	disease	0.87	disease	0.76	disease	0.83	disease	7	1	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.06	medium_impact	2.76	high_impact	0.68	0.85	23.88	7.03	0.48	N	0.96	polymorphism	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12613	12613	G	A	MI.19825	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	277	93	A	T	Gca/Aca	-2.11	0	0	probably_damaging	1	neutral	0.27	neutral	1.44	neutral	-1.31	deleterious	-3.93	high_impact	3.79	0.65	neutral	0.47	neutral	4.05	23.70	deleterious	0.4	0.5	0.61	disease	0.79	disease	0.65	disease	0.64	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.01	medium_impact	2.26	high_impact	0.73	0.85	23.88	7.03	0.38	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12614	12614	C	G	MI.19826	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	278	93	A	G	gCa/gGa	5.92	1	0	probably_damaging	1	neutral	0.12	neutral	1.39	neutral	-2.36	deleterious	-3.93	medium_impact	3.24	0.67	neutral	0.52	neutral	3.73	23.30	deleterious	0.25	0.45	0.29	neutral	0.78	disease	0.59	disease	0.63	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.25	medium_impact	1.76	medium_impact	0.75	0.85	23.88	7.03	0.54	P	0.82	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12614	12614	C	A	MI.19827	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	278	93	A	E	gCa/gAa	5.92	1	0	probably_damaging	1	neutral	0.1	neutral	1.36	deleterious	-3.53	deleterious	-4.92	high_impact	4.34	0.66	neutral	0.41	neutral	4.41	24.10	deleterious	0.16	0.45	0.6	disease	0.89	disease	0.74	disease	0.8	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.29	medium_impact	2.76	high_impact	0.59	0.8	23.88	7.03	0.63	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12614	12614	C	T	MI.19828	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	278	93	A	V	gCa/gTa	5.92	1	0	probably_damaging	1	neutral	0.74	neutral	2	neutral	1.62	deleterious	-3.94	medium_impact	2.73	0.65	neutral	0.58	neutral	4.25	23.90	deleterious	0.35	0.5	0.65	disease	0.75	disease	0.66	disease	0.57	disease	1	1	deleterious	0.37	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.48	medium_impact	1.29	medium_impact	0.71	0.85	23.88	7.03	0.52	P	0.76	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12616	12616	T	G	MI.19829	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	280	94	L	V	Ttg/Gtg	-6.93	0	0.01	probably_damaging	1	neutral	0.36	neutral	1.06	deleterious	-3.58	deleterious	-2.95	high_impact	4.34	0.51	damaging	0.07	damaging	3.26	22.80	deleterious	0.44	0.55	0.66	disease	0.69	disease	0.67	disease	0.67	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.1	medium_impact	2.76	high_impact	0.57	0.8	19.9	7.45	0.35	N	0.81	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5950	5950	G	T	MI.1983	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	47	16	G	V	gGa/gTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.93	deleterious	-5.61	neutral	-1.99	high_impact	4.84	0.55	damaging	0.11	damaging	3.59	23.20	deleterious	0.14	0.55	0.78	disease	0.89	disease	0.68	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.34	0.9	4.09	7.65	0.7	P	0.93	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12616	12616	T	A	MI.19830	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	280	94	L	M	Ttg/Atg	-6.93	0	0.01	probably_damaging	1	neutral	0.23	neutral	1.02	deleterious	-4.95	neutral	-1.97	high_impact	3.54	0.55	damaging	0.14	damaging	3.41	23.00	deleterious	0.37	0.5	0.77	disease	0.54	disease	0.59	disease	0.57	disease	1	1	deleterious	0.12	neutral	2	deleterious	0.74	deleterious	-3.6	low_impact	-0.06	medium_impact	2.03	high_impact	0.66	0.8	19.9	7.45	0.32	N	0.89	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12617	12617	T	C	MI.19831	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	281	94	L	S	tTg/tCg	-0.04	0	0	probably_damaging	1	neutral	0.24	neutral	1.13	neutral	-2.38	deleterious	-5.91	medium_impact	3.31	0.49	damaging	0.08	damaging	3.58	23.20	deleterious	0.32	0.5	0.32	neutral	0.76	disease	0.65	disease	0.62	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.04	medium_impact	1.82	medium_impact	0.56	0.8	19.9	7.45	0.29	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12617	12617	T	G	MI.19832	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	281	94	L	W	tTg/tGg	-0.04	0	0	probably_damaging	1	neutral	0.06	neutral	1	deleterious	-7.11	deleterious	-5.91	high_impact	4	0.56	damaging	0.07	damaging	3.56	23.10	deleterious	0.15	0.4	0.91	disease	0.77	disease	0.69	disease	0.78	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.43	medium_impact	2.45	high_impact	0.55	0.8	19.9	7.45	0.31	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12618	12618	G	C	MI.19833	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	282	94	L	F	ttG/ttC	7.3	0.95	0.01	probably_damaging	1	neutral	0.75	neutral	1.02	deleterious	-4.97	deleterious	-3.94	medium_impact	3.1	0.51	damaging	0.08	damaging	3.27	22.80	deleterious	0.48	0.55	0.2	neutral	0.73	disease	0.61	disease	0.61	disease	2	1	deleterious	0.38	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.5	medium_impact	1.63	medium_impact	0.71	0.85	19.9	7.45	0.38	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12618	12618	G	T	MI.19834	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	282	94	L	F	ttG/ttT	7.3	0.95	0.01	probably_damaging	1	neutral	0.75	neutral	1.02	deleterious	-4.97	deleterious	-3.94	medium_impact	3.1	0.51	damaging	0.08	damaging	3.42	23.00	deleterious	0.48	0.55	0.2	neutral	0.73	disease	0.61	disease	0.61	disease	2	1	deleterious	0.38	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.5	medium_impact	1.63	medium_impact	0.71	0.85	19.9	7.45	0.38	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12619	12619	T	G	MI.19835	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	283	95	F	V	Ttc/Gtc	-1.65	0	0	possibly_damaging	0.74	neutral	0.74	neutral	1.52	neutral	-1.28	deleterious	-6.64	medium_impact	2.9	0.78	neutral	0.48	neutral	2.21	17.54	deleterious	0.32	0.5	0.43	neutral	0.87	disease	0.65	disease	0.7	disease	4	0.69	neutral	0.5	deleterious	0	NA	0.46	deleterious	-1.18	low_impact	0.48	medium_impact	1.45	medium_impact	0.41	0.8	15.42	13.52	0.22	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12619	12619	T	A	MI.19836	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	283	95	F	I	Ttc/Atc	-1.65	0	0	possibly_damaging	0.74	neutral	0.54	neutral	1.65	neutral	-1.03	deleterious	-5.68	medium_impact	2.75	0.79	neutral	0.52	neutral	2.51	19.53	deleterious	0.33	0.5	0.49	neutral	0.87	disease	0.64	disease	0.57	disease	1	0.71	neutral	0.4	neutral	0	NA	0.49	deleterious	-1.18	low_impact	0.27	medium_impact	1.31	medium_impact	0.49	0.8	15.42	13.52	0.21	N	0.77	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12619	12619	T	C	MI.19837	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	283	95	F	L	Ttc/Ctc	-1.65	0	0	benign	0.08	neutral	1	neutral	1.61	neutral	-0.31	deleterious	-5.64	low_impact	1.7	0.83	neutral	0.74	neutral	0.80	9.46	deleterious	0.44	0.55	0.23	neutral	0.75	disease	0.56	disease	0.52	disease	0	0.08	neutral	0.96	deleterious	-6	neutral	0.13	neutral	0.26	medium_impact	1.89	high_impact	0.35	medium_impact	0.54	0.8	15.42	13.52	0.24	N	0.31	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12620	12620	T	C	MI.19838	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	284	95	F	S	tTc/tCc	2.94	0.23	0	probably_damaging	0.96	neutral	0.63	neutral	1.51	neutral	-2.38	deleterious	-7.67	medium_impact	3.4	0.94	neutral	0.6	neutral	3.90	23.50	deleterious	0.3	0.45	0.66	disease	0.8	disease	0.64	disease	0.57	disease	1	0.95	neutral	0.34	neutral	1	deleterious	0.67	deleterious	-2.06	low_impact	0.36	medium_impact	1.9	medium_impact	0.29	0.8	15.42	13.52	0.33	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12620	12620	T	A	MI.19839	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	284	95	F	Y	tTc/tAc	2.94	0.23	0	possibly_damaging	0.89	neutral	0.65	neutral	1.47	deleterious	-3.07	deleterious	-2.74	low_impact	0.9	0.8	neutral	0.89	neutral	1.09	11.17	neutral	0.31	0.45	0.65	disease	0.29	neutral	0.41	neutral	0.58	disease	2	0.87	neutral	0.38	neutral	-3	neutral	0.60	deleterious	-1.61	low_impact	0.38	medium_impact	-0.38	medium_impact	0.53	0.8	15.42	13.52	0.31	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5952	5952	A	C	MI.1984	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	49	17	T	P	Aca/Cca	-3.58	0	0	probably_damaging	1	deleterious	0	neutral	2.74	deleterious	-4.93	neutral	-2.19	high_impact	4.47	0.54	damaging	0.09	damaging	3.36	22.90	deleterious	0.11	0.55	0.71	disease	0.89	disease	0.7	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.03	high_impact	0.62	0.9	3.51	6.79	0.4	N	0.92	disease_causing	0.85	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12620	12620	T	G	MI.19840	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	284	95	F	C	tTc/tGc	2.94	0.23	0	probably_damaging	0.98	neutral	0.11	neutral	1.43	deleterious	-4.23	deleterious	-7.65	medium_impact	3.4	0.71	neutral	0.44	neutral	3.89	23.50	deleterious	0.22	0.45	0.67	disease	0.89	disease	0.68	disease	0.76	disease	5	0.99	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-2.35	low_impact	-0.27	medium_impact	1.9	medium_impact	0.22	0.8	15.42	13.52	0.4	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12621	12621	C	A	MI.19841	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	285	95	F	L	ttC/ttA	0.64	0.13	0	benign	0.08	neutral	1	neutral	1.61	neutral	-0.31	deleterious	-5.64	low_impact	1.7	0.83	neutral	0.74	neutral	1.50	13.34	neutral	0.44	0.55	0.23	neutral	0.75	disease	0.56	disease	0.52	disease	0	0.08	neutral	0.96	deleterious	-6	neutral	0.13	neutral	0.26	medium_impact	1.89	high_impact	0.35	medium_impact	0.54	0.8	15.42	13.52	0.26	N	0.31	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12621	12621	C	G	MI.19842	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	285	95	F	L	ttC/ttG	0.64	0.13	0	benign	0.08	neutral	1	neutral	1.61	neutral	-0.31	deleterious	-5.64	low_impact	1.7	0.83	neutral	0.74	neutral	1.15	11.47	neutral	0.44	0.55	0.23	neutral	0.75	disease	0.56	disease	0.52	disease	0	0.08	neutral	0.96	deleterious	-6	neutral	0.13	neutral	0.26	medium_impact	1.89	high_impact	0.35	medium_impact	0.54	0.8	15.42	13.52	0.27	N	0.31	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12622	12622	G	T	MI.19843	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	286	96	V	F	Gtt/Ttt	-3.94	0	0	possibly_damaging	0.88	neutral	0.93	neutral	0.52	deleterious	-6.82	deleterious	-4.73	high_impact	4.22	0.52	damaging	0.45	neutral	3.56	23.10	deleterious	0.16	0.45	0.89	disease	0.9	disease	0.71	disease	0.82	disease	6	0.87	neutral	0.53	deleterious	1	deleterious	0.79	deleterious	-1.57	low_impact	0.85	medium_impact	2.65	high_impact	0.70	0.85	9.29	13.35	0.37	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12622	12622	G	C	MI.19844	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	286	96	V	L	Gtt/Ctt	-3.94	0	0	benign	0.4	neutral	1	neutral	0.58	deleterious	-4.38	deleterious	-2.76	high_impact	4.22	0.51	damaging	0.52	neutral	1.62	13.96	neutral	0.33	0.5	0.65	disease	0.76	disease	0.63	disease	0.65	disease	3	0.4	neutral	0.8	deleterious	-2	neutral	0.37	neutral	-0.58	medium_impact	1.89	high_impact	2.65	high_impact	0.66	0.8	9.29	13.35	0.35	N	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12622	12622	G	A	MI.19845	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	286	96	V	I	Gtt/Att	-3.94	0	0	benign	0.03	neutral	0.55	neutral	1.07	neutral	-1.21	neutral	-0.79	low_impact	1.4	0.75	neutral	0.91	neutral	0.30	5.66	deleterious	0.45	0.55	0.38	neutral	0.47	neutral	0.47	neutral	0.42	neutral	2	0.42	neutral	0.76	deleterious	-6	neutral	0.17	neutral	0.69	medium_impact	0.28	medium_impact	0.08	medium_impact	0.86	0.9	9.29	13.35	0.36	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	G12622A	Leigh Disease	+	+	Significance unclear	1	.	N	N	neutral
chrM	12623	12623	T	C	MI.19846	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	287	96	V	A	gTt/gCt	1.1	0.76	0	possibly_damaging	0.53	neutral	0.57	neutral	0.53	deleterious	-5.86	deleterious	-3.94	high_impact	4.22	0.52	damaging	0.58	neutral	3.02	22.30	deleterious	0.29	0.45	0.82	disease	0.65	disease	0.67	disease	0.7	disease	4	0.48	neutral	0.52	deleterious	1	deleterious	0.60	deleterious	-0.8	medium_impact	0.3	medium_impact	2.65	high_impact	0.45	0.8	9.29	13.35	0.4	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12623	12623	T	A	MI.19847	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	287	96	V	D	gTt/gAt	1.1	0.76	0	probably_damaging	0.93	neutral	0.18	neutral	0.51	deleterious	-9.01	deleterious	-6.8	high_impact	4.22	0.55	damaging	0.44	neutral	4.25	23.90	deleterious	0.1	0.4	0.97	disease	0.88	disease	0.79	disease	0.86	disease	7	0.96	neutral	0.13	neutral	2	deleterious	0.82	deleterious	-1.81	low_impact	-0.13	medium_impact	2.65	high_impact	0.54	0.8	9.29	13.35	0.46	N	0.65	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12623	12623	T	G	MI.19848	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	287	96	V	G	gTt/gGt	1.1	0.76	0	possibly_damaging	0.86	neutral	0.32	neutral	0.51	deleterious	-8.39	deleterious	-6.9	high_impact	4.22	0.52	damaging	0.57	neutral	3.59	23.20	deleterious	0.16	0.45	0.95	disease	0.82	disease	0.7	disease	0.83	disease	7	0.88	neutral	0.23	neutral	1	deleterious	0.78	deleterious	-1.5	low_impact	0.05	medium_impact	2.65	high_impact	0.54	0.8	9.29	13.35	0.38	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12625	12625	A	G	MI.19849	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	289	97	T	A	Aca/Gca	-11.28	0	0	probably_damaging	1	neutral	0.61	neutral	1.39	neutral	-1.38	deleterious	-4.93	medium_impact	3.23	0.58	damaging	0.15	damaging	3.32	22.90	deleterious	0.61	0.65	0.65	disease	0.68	disease	0.63	disease	0.6	disease	2	1	deleterious	0.31	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.34	medium_impact	1.75	medium_impact	0.43	0.8	21.89	7.34	0.22	N	0.70	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5952	5952	A	T	MI.1985	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	49	17	T	S	Aca/Tca	-3.58	0	0	probably_damaging	0.99	deleterious	0.03	neutral	2.78	neutral	-1.91	neutral	-1.44	medium_impact	2.4	0.69	neutral	0.12	damaging	3.14	22.60	deleterious	0.36	0.55	0.48	neutral	0.69	disease	0.32	neutral	0.51	disease	0	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-2.64	low_impact	-0.65	medium_impact	1.12	medium_impact	0.68	0.9	3.51	6.79	0.3	N	0.79	polymorphism	0.73	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12625	12625	A	T	MI.19850	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	289	97	T	S	Aca/Tca	-11.28	0	0	probably_damaging	1	neutral	0.65	neutral	1.8	neutral	0.83	deleterious	-3.94	low_impact	1.88	0.6	neutral	0.2	damaging	3.06	22.40	deleterious	0.52	0.6	0.69	disease	0.4	neutral	0.51	disease	0.59	disease	2	1	deleterious	0.33	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.38	medium_impact	0.51	medium_impact	0.75	0.85	21.89	7.34	0.25	N	0.69	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12625	12625	A	C	MI.19851	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	289	97	T	P	Aca/Cca	-11.28	0	0	probably_damaging	1	neutral	0.22	neutral	1.28	deleterious	-4.34	deleterious	-5.91	high_impact	4.28	0.63	neutral	0.07	damaging	3.33	22.90	deleterious	0.13	0.4	0.86	disease	0.85	disease	0.79	disease	0.85	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	-0.07	medium_impact	2.71	high_impact	0.58	0.8	21.89	7.34	0.41	N	0.99	polymorphism	0.98	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12626	12626	C	T	MI.19852	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	290	97	T	M	aCa/aTa	2.71	0.76	0	probably_damaging	1	neutral	0.4	neutral	1.27	deleterious	-4.52	deleterious	-5.91	high_impact	4.28	0.62	neutral	0.07	damaging	3.82	23.40	deleterious	0.36	0.5	0.78	disease	0.77	disease	0.71	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.74	deleterious	-3.6	low_impact	0.14	medium_impact	2.71	high_impact	0.75	0.85	21.89	7.34	0.36	N	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12626	12626	C	A	MI.19853	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	290	97	T	K	aCa/aAa	2.71	0.76	0	probably_damaging	1	neutral	0.27	neutral	1.3	deleterious	-3.21	deleterious	-5.91	high_impact	4.28	0.62	neutral	0.06	damaging	4.24	23.90	deleterious	0.19	0.45	0.66	disease	0.88	disease	0.78	disease	0.81	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	-0.01	medium_impact	2.71	high_impact	0.69	0.85	21.89	7.34	0.49	N	0.98	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12628	12628	T	C	MI.19854	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	292	98	W	R	Tgg/Cgg	-6.93	0	0	probably_damaging	1	neutral	0.31	neutral	1.42	deleterious	-3	deleterious	-13.79	high_impact	3.77	0.61	neutral	0.15	damaging	3.41	23.00	deleterious	0.35	0.5	0.73	disease	0.94	disease	0.79	disease	0.87	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.04	medium_impact	2.24	high_impact	0.36	0.8	29.19	7.32	0.45	N	0.97	polymorphism	0.86	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12628	12628	T	G	MI.19855	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	292	98	W	G	Tgg/Ggg	-6.93	0	0	probably_damaging	1	neutral	0.35	neutral	1.41	deleterious	-3.13	deleterious	-12.81	high_impact	3.52	0.62	neutral	0.18	damaging	3.76	23.30	deleterious	0.35	0.5	0.74	disease	0.88	disease	0.77	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.08	medium_impact	2.01	high_impact	0.33	0.8	29.19	7.32	0.4	N	0.97	polymorphism	0.7	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12629	12629	G	T	MI.19856	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	293	98	W	L	tGg/tTg	4.54	1	0	probably_damaging	1	neutral	1	neutral	1.55	neutral	-0.27	deleterious	-12.81	medium_impact	3.43	0.64	neutral	0.12	damaging	4.08	23.70	deleterious	0.24	0.45	0.36	neutral	0.88	disease	0.76	disease	0.74	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.76	deleterious	-3.6	low_impact	1.89	high_impact	1.93	medium_impact	0.32	0.8	29.19	7.32	0.39	N	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12629	12629	G	C	MI.19857	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	293	98	W	S	tGg/tCg	4.54	1	0	probably_damaging	1	neutral	0.64	neutral	1.62	neutral	0.29	deleterious	-13.79	medium_impact	2.98	0.59	damaging	0.15	damaging	3.86	23.40	deleterious	0.28	0.45	0.41	neutral	0.88	disease	0.75	disease	0.64	disease	3	1	deleterious	0.32	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.37	medium_impact	1.52	medium_impact	0.33	0.8	29.19	7.32	0.38	N	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12630	12630	G	C	MI.19858	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	294	98	W	C	tgG/tgC	7.3	1	0.03	probably_damaging	1	neutral	0.16	neutral	1.41	deleterious	-3.53	deleterious	-12.81	high_impact	4.33	0.64	neutral	0.11	damaging	3.85	23.40	deleterious	0.33	0.5	0.66	disease	0.92	disease	0.78	disease	0.82	disease	6	1	deleterious	0.08	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.17	medium_impact	2.75	high_impact	0.29	0.8	29.19	7.32	0.54	P	0.98	disease_causing	1	0.06	.	.	.	.	.	.	COSM488732	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12630	12630	G	T	MI.19859	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	294	98	W	C	tgG/tgT	7.3	1	0.03	probably_damaging	1	neutral	0.16	neutral	1.41	deleterious	-3.53	deleterious	-12.81	high_impact	4.33	0.64	neutral	0.11	damaging	3.97	23.60	deleterious	0.33	0.5	0.66	disease	0.92	disease	0.78	disease	0.82	disease	6	1	deleterious	0.08	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.17	medium_impact	2.75	high_impact	0.29	0.8	29.19	7.32	0.54	P	0.98	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5952	5952	A	G	MI.1986	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	49	17	T	A	Aca/Gca	-3.58	0	0	probably_damaging	0.99	deleterious	0	neutral	2.79	neutral	-2.7	neutral	-1.81	high_impact	4.12	0.72	neutral	0.08	damaging	3.34	22.90	deleterious	0.41	0.55	0.32	neutral	0.72	disease	0.57	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.72	deleterious	-2.64	low_impact	-1.48	low_impact	2.71	high_impact	0.56	0.9	3.51	6.79	0.33	N	0.69	disease_causing	0.52	0.04	rs879232447	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12631	12631	T	C	MI.19860	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	295	99	S	P	Tcc/Ccc	-0.27	0.55	0	possibly_damaging	0.81	neutral	0.2	neutral	1.37	deleterious	-3.96	deleterious	-4.92	high_impact	4.25	0.86	neutral	0.44	neutral	3.55	23.10	deleterious	0.13	0.4	0.87	disease	0.89	disease	0.77	disease	0.86	disease	7	0.89	neutral	0.2	neutral	1	deleterious	0.71	deleterious	-1.34	low_impact	-0.1	medium_impact	2.68	high_impact	0.59	0.8	8.29	12.83	0.48	N	0.98	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12631	12631	T	G	MI.19861	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	295	99	S	A	Tcc/Gcc	-0.27	0.55	0	benign	0.02	neutral	0.38	neutral	1.44	neutral	-1.47	deleterious	-2.95	medium_impact	2.34	0.77	neutral	0.71	neutral	1.57	13.67	neutral	0.38	0.5	0.27	neutral	0.59	disease	0.47	neutral	0.44	neutral	1	0.6	neutral	0.68	deleterious	-3	neutral	0.15	neutral	0.86	medium_impact	0.12	medium_impact	0.94	medium_impact	0.65	0.8	8.29	12.83	0.36	N	0.49	disease_causing	0.83	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12631	12631	T	A	MI.19862	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	295	99	S	T	Tcc/Acc	-0.27	0.55	0	benign	0.32	neutral	0.4	neutral	1.42	neutral	-2.07	deleterious	-2.95	high_impact	3.56	0.75	neutral	0.53	neutral	1.96	15.98	deleterious	0.31	0.5	0.26	neutral	0.69	disease	0.57	disease	0.59	disease	2	0.52	neutral	0.54	deleterious	-2	neutral	0.39	neutral	-0.44	medium_impact	0.14	medium_impact	2.05	high_impact	0.80	0.85	8.29	12.83	0.35	N	0.71	disease_causing	0.94	0.04	.	.	.	.	.	.	.	.	.	T12631A	found in 2 sCJD patients	+	-	Reported	2	.	P	P	damaging
chrM	12632	12632	C	G	MI.19863	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	296	99	S	C	tCc/tGc	2.94	0.99	0	benign	0.02	neutral	0.17	neutral	1.43	neutral	-1.71	deleterious	-4.89	medium_impact	3.01	0.75	neutral	0.5	neutral	3.28	22.80	deleterious	0.28	0.45	0.55	disease	0.84	disease	0.59	disease	0.66	disease	3	0.82	neutral	0.58	deleterious	-3	neutral	0.70	deleterious	0.86	medium_impact	-0.15	medium_impact	1.55	medium_impact	0.63	0.8	8.29	12.83	0.51	N	0.99	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12632	12632	C	T	MI.19864	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	296	99	S	F	tCc/tTc	2.94	0.99	0	possibly_damaging	0.89	neutral	0.81	neutral	1.45	neutral	-1.38	deleterious	-5.9	high_impact	4.25	0.76	neutral	0.42	neutral	4.01	23.60	deleterious	0.27	0.45	0.89	disease	0.9	disease	0.68	disease	0.8	disease	6	0.87	neutral	0.46	neutral	1	deleterious	0.80	deleterious	-1.61	low_impact	0.58	medium_impact	2.68	high_impact	0.49	0.8	8.29	12.83	0.43	N	0.99	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12632	12632	C	A	MI.19865	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	296	99	S	Y	tCc/tAc	2.94	0.99	0	probably_damaging	0.92	neutral	0.93	neutral	1.39	neutral	-2.97	deleterious	-5.9	high_impact	4.25	0.79	neutral	0.41	neutral	3.80	23.40	deleterious	0.22	0.45	0.91	disease	0.89	disease	0.69	disease	0.82	disease	6	0.91	neutral	0.51	deleterious	2	deleterious	0.81	deleterious	-1.75	low_impact	0.85	medium_impact	2.68	high_impact	0.56	0.8	8.29	12.83	0.4	N	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12634	12634	A	G	MI.19866	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	298	100	I	V	Atc/Gtc	-10.83	0	0.01	probably_damaging	1	neutral	0.5	neutral	1.94	neutral	0.84	neutral	-0.98	medium_impact	2.92	0.64	neutral	0.68	neutral	2.89	21.80	deleterious	0.5	0.6	0.45	neutral	0.27	neutral	0.63	disease	0.42	neutral	2	1	deleterious	0.25	neutral	1	deleterious	0.62	deleterious	-3.6	low_impact	0.23	medium_impact	1.46	medium_impact	0.49	0.8	26.87	7.07	0.43	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	A12634G	Thyroid Cancer Cell Line	+	-	Reported	2	.	P	P	neutral
chrM	12634	12634	A	T	MI.19867	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	298	100	I	F	Atc/Ttc	-10.83	0	0.01	probably_damaging	1	neutral	0.7	neutral	0.97	deleterious	-5.81	deleterious	-3.94	high_impact	4.4	0.55	damaging	0.33	neutral	3.71	23.30	deleterious	0.27	0.45	0.8	disease	0.81	disease	0.71	disease	0.75	disease	5	1	deleterious	0.35	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.44	medium_impact	2.82	high_impact	0.72	0.85	26.87	7.07	0.35	N	0.96	polymorphism	0.57	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12634	12634	A	C	MI.19868	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	298	100	I	L	Atc/Ctc	-10.83	0	0.01	probably_damaging	1	neutral	0.65	neutral	1.03	deleterious	-3.37	neutral	-1.97	high_impact	4.4	0.54	damaging	0.43	neutral	3.63	23.20	deleterious	0.32	0.5	0.34	neutral	0.69	disease	0.6	disease	0.65	disease	3	1	deleterious	0.33	neutral	2	deleterious	0.64	deleterious	-3.6	low_impact	0.38	medium_impact	2.82	high_impact	0.62	0.8	26.87	7.07	0.39	N	0.86	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12635	12635	T	G	MI.19869	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	299	100	I	S	aTc/aGc	5.46	1	0	probably_damaging	1	neutral	0.4	neutral	0.96	deleterious	-6.64	deleterious	-5.91	high_impact	4.4	0.55	damaging	0.46	neutral	4.13	23.80	deleterious	0.25	0.45	0.36	neutral	0.84	disease	0.68	disease	0.73	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.72	deleterious	-3.6	low_impact	0.14	medium_impact	2.82	high_impact	0.52	0.8	26.87	7.07	0.48	N	0.96	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5953	5953	C	A	MI.1987	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	50	17	T	K	aCa/aAa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.88	deleterious	-4.2	neutral	-2.19	high_impact	3.58	0.63	neutral	0.09	damaging	4.32	24.00	deleterious	0.17	0.55	0.6	disease	0.91	disease	0.69	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.21	high_impact	0.75	0.9	3.51	6.79	0.49	N	0.88	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12635	12635	T	A	MI.19870	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	299	100	I	N	aTc/aAc	5.46	1	0	probably_damaging	1	neutral	0.31	neutral	0.95	deleterious	-7.66	deleterious	-6.9	high_impact	4.4	0.53	damaging	0.4	neutral	4.26	23.90	deleterious	0.23	0.45	0.89	disease	0.85	disease	0.71	disease	0.81	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.04	medium_impact	2.82	high_impact	0.65	0.8	26.87	7.07	0.54	P	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12635	12635	T	C	MI.19871	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	299	100	I	T	aTc/aCc	5.46	1	0	probably_damaging	1	neutral	0.39	neutral	0.97	deleterious	-5.24	deleterious	-4.92	high_impact	4.4	0.52	damaging	0.42	neutral	3.26	22.80	deleterious	0.47	0.55	0.59	disease	0.75	disease	0.67	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.13	medium_impact	2.82	high_impact	0.64	0.8	26.87	7.07	0.55	P	0.96	disease_causing	1	0.05	.	.	.	.	.	.	COSM6716770	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12636	12636	C	G	MI.19872	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	300	100	I	M	atC/atG	4.54	1	0	probably_damaging	1	neutral	0.22	neutral	0.97	deleterious	-5.34	deleterious	-2.96	high_impact	4.4	0.55	damaging	0.51	neutral	3.18	22.70	deleterious	0.36	0.5	0.8	disease	0.62	disease	0.68	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.73	deleterious	-3.6	low_impact	-0.07	medium_impact	2.82	high_impact	0.80	0.85	26.87	7.07	0.53	P	0.76	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12636	12636	C	A	MI.19873	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	300	100	I	M	atC/atA	4.54	1	0	probably_damaging	1	neutral	0.22	neutral	0.97	deleterious	-5.34	deleterious	-2.96	high_impact	4.4	0.55	damaging	0.51	neutral	3.70	23.30	deleterious	0.36	0.5	0.8	disease	0.62	disease	0.68	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.73	deleterious	-3.6	low_impact	-0.07	medium_impact	2.82	high_impact	0.80	0.85	26.87	7.07	0.54	P	0.76	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12637	12637	A	C	MI.19874	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	301	101	M	L	Ata/Cta	-6.24	0	0	benign	0.26	neutral	0.65	neutral	1.66	neutral	0.54	deleterious	-2.72	neutral_impact	0.08	0.76	neutral	0.88	neutral	0.43	6.87	deleterious	0.45	0.55	0.28	neutral	0.38	neutral	0.41	neutral	0.44	neutral	1	0.25	neutral	0.7	deleterious	-6	neutral	0.54	deleterious	-0.32	medium_impact	0.38	medium_impact	-1.13	low_impact	0.48	0.8	21.39	16.37	0.3	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12637	12637	A	G	MI.19875	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	301	101	M	V	Ata/Gta	-6.24	0	0	benign	0.04	neutral	0.5	neutral	1.5	neutral	-0.91	deleterious	-3.48	low_impact	1.48	0.8	neutral	0.71	neutral	1.53	13.46	neutral	0.49	0.55	0.65	disease	0.8	disease	0.61	disease	0.61	disease	2	0.46	neutral	0.73	deleterious	-6	neutral	0.70	deleterious	0.57	medium_impact	0.23	medium_impact	0.15	medium_impact	0.44	0.8	21.39	16.37	0.21	N	0.82	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12637	12637	A	T	MI.19876	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	301	101	M	L	Ata/Tta	-6.24	0	0	benign	0.26	neutral	0.65	neutral	1.66	neutral	0.54	deleterious	-2.72	neutral_impact	0.08	0.76	neutral	0.88	neutral	0.50	7.43	deleterious	0.45	0.55	0.28	neutral	0.38	neutral	0.41	neutral	0.44	neutral	1	0.25	neutral	0.7	deleterious	-6	neutral	0.54	deleterious	-0.32	medium_impact	0.38	medium_impact	-1.13	low_impact	0.48	0.8	21.39	16.37	0.3	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12638	12638	T	C	MI.19877	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	302	101	M	T	aTa/aCa	-0.04	0	0	possibly_damaging	0.54	neutral	0.39	neutral	1.46	neutral	-1.75	deleterious	-5.3	medium_impact	2.06	0.81	neutral	0.64	neutral	2.79	21.30	deleterious	0.45	0.55	0.74	disease	0.79	disease	0.66	disease	0.63	disease	3	0.61	neutral	0.43	neutral	0	NA	0.80	deleterious	-0.81	medium_impact	0.13	medium_impact	0.68	medium_impact	0.33	0.8	21.39	16.37	0.24	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12638	12638	T	A	MI.19878	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	302	101	M	K	aTa/aAa	-0.04	0	0	possibly_damaging	0.78	neutral	0.29	neutral	1.43	neutral	-2.69	deleterious	-5.55	medium_impact	3.47	0.62	neutral	0.16	damaging	3.80	23.40	deleterious	0.23	0.45	0.8	disease	0.9	disease	0.74	disease	0.83	disease	7	0.83	neutral	0.26	neutral	0	NA	0.84	deleterious	-1.27	low_impact	0.02	medium_impact	1.97	medium_impact	0.44	0.8	21.39	16.37	0.32	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12639	12639	A	T	MI.19879	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	303	101	M	I	atA/atT	4.54	1	0	benign	0.23	neutral	0.4	neutral	1.55	neutral	-0.29	deleterious	-3.56	low_impact	1.57	0.8	neutral	0.25	damaging	3.28	22.80	deleterious	0.48	0.55	0.69	disease	0.86	disease	0.6	disease	0.6	disease	2	0.52	neutral	0.59	deleterious	-6	neutral	0.77	deleterious	-0.25	medium_impact	0.14	medium_impact	0.23	medium_impact	0.63	0.8	21.39	16.37	0.37	N	0.83	polymorphism	0.7	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5953	5953	C	T	MI.1988	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	50	17	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	neutral	0.09	neutral	2.78	deleterious	-5.65	neutral	-2.15	medium_impact	2.11	0.71	neutral	0.08	damaging	3.81	23.40	deleterious	0.31	0.55	0.49	neutral	0.82	disease	0.34	neutral	0.57	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.75	deleterious	-3.58	low_impact	-0.37	medium_impact	0.85	medium_impact	0.74	0.9	3.51	6.79	0.45	N	0.96	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12639	12639	A	C	MI.19880	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	303	101	M	I	atA/atC	4.54	1	0	benign	0.23	neutral	0.4	neutral	1.55	neutral	-0.29	deleterious	-3.56	low_impact	1.57	0.8	neutral	0.25	damaging	3.19	22.70	deleterious	0.48	0.55	0.69	disease	0.86	disease	0.6	disease	0.6	disease	2	0.52	neutral	0.59	deleterious	-6	neutral	0.77	deleterious	-0.25	medium_impact	0.14	medium_impact	0.23	medium_impact	0.63	0.8	21.39	16.37	0.36	N	0.83	polymorphism	0.7	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12640	12640	G	C	MI.19881	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	304	102	E	Q	Gaa/Caa	1.1	1	0	probably_damaging	1	neutral	0.3	neutral	1.45	neutral	-1.8	deleterious	-2.96	medium_impact	2.24	0.77	neutral	0.66	neutral	3.11	22.50	deleterious	0.43	0.55	0.62	disease	0.61	disease	0.48	neutral	0.47	neutral	1	1	deleterious	0.15	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.03	medium_impact	0.84	medium_impact	0.86	0.9	7.3	11.94	0.37	N	0.18	disease_causing	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12640	12640	G	A	MI.19882	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	304	102	E	K	Gaa/Aaa	1.1	1	0	probably_damaging	1	neutral	0.31	neutral	1.43	neutral	-2.69	deleterious	-3.94	high_impact	3.89	0.68	neutral	0.16	damaging	4.33	24.00	deleterious	0.26	0.45	0.34	neutral	0.9	disease	0.76	disease	0.78	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.04	medium_impact	2.35	high_impact	0.57	0.8	7.3	11.94	0.5	N	0.82	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12641	12641	A	C	MI.19883	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	305	102	E	A	gAa/gCa	2.71	1	0	probably_damaging	1	neutral	0.52	neutral	1.46	neutral	-1.54	deleterious	-5.91	high_impact	4.24	0.72	neutral	0.18	damaging	3.48	23.10	deleterious	0.26	0.45	0.59	disease	0.82	disease	0.65	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.25	medium_impact	2.67	high_impact	0.56	0.8	7.3	11.94	0.42	N	0.67	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12641	12641	A	G	MI.19884	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	305	102	E	G	gAa/gGa	2.71	1	0	probably_damaging	1	neutral	0.34	neutral	1.42	deleterious	-3.19	deleterious	-6.9	high_impact	3.89	0.68	neutral	0.2	damaging	3.99	23.60	deleterious	0.27	0.45	0.78	disease	0.84	disease	0.69	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.07	medium_impact	2.35	high_impact	0.49	0.8	7.3	11.94	0.43	N	0.67	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12641	12641	A	T	MI.19885	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	305	102	E	V	gAa/gTa	2.71	1	0	probably_damaging	1	neutral	0.51	neutral	1.49	neutral	-1.04	deleterious	-6.9	medium_impact	3.27	0.71	neutral	0.17	damaging	3.95	23.60	deleterious	0.25	0.45	0.48	neutral	0.89	disease	0.7	disease	0.59	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.24	medium_impact	1.78	medium_impact	0.64	0.8	7.3	11.94	0.4	N	0.89	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12642	12642	A	T	MI.19886	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	306	102	E	D	gaA/gaT	6.84	1	0	probably_damaging	1	neutral	0.22	neutral	1.41	deleterious	-3.73	deleterious	-2.96	medium_impact	3.04	0.72	neutral	0.2	damaging	3.61	23.20	deleterious	0.32	0.5	0.79	disease	0.77	disease	0.54	disease	0.64	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.07	medium_impact	1.57	medium_impact	0.76	0.85	7.3	11.94	0.56	P	0.77	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12642	12642	A	C	MI.19887	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	306	102	E	D	gaA/gaC	6.84	1	0	probably_damaging	1	neutral	0.22	neutral	1.41	deleterious	-3.73	deleterious	-2.96	medium_impact	3.04	0.72	neutral	0.2	damaging	3.49	23.10	deleterious	0.32	0.5	0.79	disease	0.77	disease	0.54	disease	0.64	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.07	medium_impact	1.57	medium_impact	0.76	0.85	7.3	11.94	0.56	P	0.77	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12643	12643	T	A	MI.19888	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	307	103	F	I	Ttc/Atc	0.41	0.99	0	probably_damaging	1	neutral	0.54	neutral	1.06	deleterious	-5.69	deleterious	-5.85	high_impact	4.34	0.59	damaging	0.17	damaging	4.47	24.20	deleterious	0.26	0.45	0.55	disease	0.88	disease	0.75	disease	0.8	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.27	medium_impact	2.76	high_impact	0.52	0.8	21.39	7.14	0.52	P	0.95	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12643	12643	T	G	MI.19889	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	307	103	F	V	Ttc/Gtc	0.41	0.99	0	probably_damaging	1	neutral	0.53	neutral	1.06	deleterious	-5.67	deleterious	-6.8	high_impact	4.34	0.56	damaging	0.16	damaging	4.06	23.70	deleterious	0.26	0.45	0.63	disease	0.87	disease	0.75	disease	0.81	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.26	medium_impact	2.76	high_impact	0.51	0.8	21.39	7.14	0.49	N	0.95	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5955	5955	C	G	MI.1989	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	52	18	L	V	Cta/Gta	-2.42	0	0	probably_damaging	0.99	deleterious	0	neutral	2.7	neutral	-0.82	neutral	-1.12	high_impact	4.33	0.55	damaging	0.12	damaging	2.86	21.70	deleterious	0.23	0.55	0.41	neutral	0.69	disease	0.59	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.9	high_impact	0.64	0.9	2.92	7.13	0.39	N	0.66	polymorphism	0.95	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12643	12643	T	C	MI.19890	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	307	103	F	L	Ttc/Ctc	0.41	0.99	0	probably_damaging	1	neutral	0.86	neutral	1.11	deleterious	-3.39	deleterious	-5.85	high_impact	4.34	0.53	damaging	0.16	damaging	4.07	23.70	deleterious	0.45	0.55	0.35	neutral	0.82	disease	0.73	disease	0.73	disease	5	1	deleterious	0.43	neutral	2	deleterious	0.71	deleterious	-3.6	low_impact	0.67	medium_impact	2.76	high_impact	0.68	0.85	21.39	7.14	0.4	N	0.92	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12644	12644	T	C	MI.19891	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	308	103	F	S	tTc/tCc	5.69	1	0	probably_damaging	1	neutral	0.51	neutral	1.06	deleterious	-6.2	deleterious	-7.79	high_impact	4.34	0.61	neutral	0.17	damaging	4.15	23.80	deleterious	0.25	0.45	0.68	disease	0.86	disease	0.73	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.24	medium_impact	2.76	high_impact	0.39	0.8	21.39	7.14	0.57	P	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12644	12644	T	G	MI.19892	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	308	103	F	C	tTc/tGc	5.69	1	0	probably_damaging	1	neutral	0.16	neutral	1.05	deleterious	-7.68	deleterious	-7.79	high_impact	4.34	0.57	damaging	0.16	damaging	3.96	23.60	deleterious	0.3	0.45	0.89	disease	0.89	disease	0.77	disease	0.85	disease	7	1	deleterious	0.08	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.17	medium_impact	2.76	high_impact	0.33	0.8	21.39	7.14	0.56	P	0.99	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12644	12644	T	A	MI.19893	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	308	103	F	Y	tTc/tAc	5.69	1	0	probably_damaging	1	neutral	1	neutral	2.21	neutral	1.46	deleterious	-2.73	medium_impact	2.22	0.62	neutral	0.2	damaging	4.26	23.90	deleterious	0.29	0.45	0.31	neutral	0.56	disease	0.72	disease	0.55	disease	1	1	deleterious	0.5	deleterious	1	deleterious	0.70	deleterious	-3.6	low_impact	1.89	high_impact	0.83	medium_impact	0.58	0.8	21.39	7.14	0.5	N	0.88	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12645	12645	C	G	MI.19894	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	309	103	F	L	ttC/ttG	3.63	1	0	probably_damaging	1	neutral	0.86	neutral	1.11	deleterious	-3.39	deleterious	-5.85	high_impact	4.34	0.53	damaging	0.16	damaging	4.22	23.90	deleterious	0.45	0.55	0.35	neutral	0.82	disease	0.73	disease	0.73	disease	5	1	deleterious	0.43	neutral	2	deleterious	0.71	deleterious	-3.6	low_impact	0.67	medium_impact	2.76	high_impact	0.68	0.85	21.39	7.14	0.45	N	0.92	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12645	12645	C	A	MI.19895	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	309	103	F	L	ttC/ttA	3.63	1	0	probably_damaging	1	neutral	0.86	neutral	1.11	deleterious	-3.39	deleterious	-5.85	high_impact	4.34	0.53	damaging	0.16	damaging	4.45	24.20	deleterious	0.45	0.55	0.35	neutral	0.82	disease	0.73	disease	0.73	disease	5	1	deleterious	0.43	neutral	2	deleterious	0.71	deleterious	-3.6	low_impact	0.67	medium_impact	2.76	high_impact	0.68	0.85	21.39	7.14	0.46	N	0.92	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12646	12646	T	G	MI.19896	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	310	104	S	A	Tca/Gca	-1.88	0	0	probably_damaging	1	neutral	0.54	neutral	0.75	neutral	-2.3	deleterious	-2.96	medium_impact	2	0.6	damaging	0.48	neutral	1.30	12.29	neutral	0.25	0.45	0.55	disease	0.16	neutral	0.42	neutral	0.23	neutral	5	1	deleterious	0.27	neutral	1	deleterious	0.69	deleterious	-3.6	low_impact	0.27	medium_impact	0.62	medium_impact	0.86	0.9	26.87	7.04	0.28	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12646	12646	T	C	MI.19897	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	310	104	S	P	Tca/Cca	-1.88	0	0	probably_damaging	1	neutral	0.22	neutral	0.45	deleterious	-6.78	deleterious	-4.93	high_impact	4.21	0.42	damaging	0.05	damaging	3.80	23.40	deleterious	0.18	0.45	0.92	disease	0.91	disease	0.81	disease	0.88	disease	8	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.07	medium_impact	2.64	high_impact	0.77	0.85	26.87	7.04	0.45	N	0.98	polymorphism	0.98	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12646	12646	T	A	MI.19898	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	310	104	S	T	Tca/Aca	-1.88	0	0	probably_damaging	1	neutral	0.42	neutral	0.59	deleterious	-3.4	deleterious	-2.96	medium_impact	2.68	0.58	damaging	0.3	neutral	3.48	23.10	deleterious	0.22	0.45	0.8	disease	0.64	disease	0.55	disease	0.58	disease	2	1	deleterious	0.21	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.16	medium_impact	1.25	medium_impact	0.87	0.9	26.87	7.04	0.26	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12647	12647	C	G	MI.19899	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	311	104	S	W	tCa/tGa	0.87	0.8	0	probably_damaging	1	neutral	0.19	neutral	0.44	deleterious	-10.14	deleterious	-6.9	high_impact	4.21	0.48	damaging	0.07	damaging	4.17	23.80	deleterious	0.11	0.4	0.98	disease	0.92	disease	0.75	disease	0.87	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.12	medium_impact	2.64	high_impact	0.51	0.8	26.87	7.04	0.37	N	0.99	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8619	8619	C	G	MI.199	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	93	31	I	M	atC/atG	0.59	0	0	benign	0.38	neutral	0.08	neutral	4.31	neutral	-1.22	neutral	-0.51	low_impact	1.11	0.94	neutral	0.77	neutral	0.54	7.71	deleterious	0.57	0.65	0.62	disease	0.29	neutral	0.2	neutral	0.56	disease	1	0.91	neutral	0.35	neutral	-6	neutral	0.36	neutral	-0.55	medium_impact	-0.31	medium_impact	-0.15	medium_impact	0.40	0.9	28.32	22.32	0.47	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5955	5955	C	A	MI.1990	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	52	18	L	M	Cta/Ata	-2.42	0	0	probably_damaging	1	neutral	0.15	neutral	2.71	neutral	-0.7	neutral	-0.53	low_impact	1.33	0.52	damaging	0.27	damaging	1.93	15.75	deleterious	0.2	0.55	0.31	neutral	0.37	neutral	0.2	neutral	0.4	neutral	2	1	deleterious	0.08	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.23	medium_impact	0.13	medium_impact	0.70	0.9	2.92	7.13	0.49	N	0.59	polymorphism	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12647	12647	C	T	MI.19900	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	311	104	S	L	tCa/tTa	0.87	0.8	0	probably_damaging	1	neutral	0.67	neutral	0.45	deleterious	-6.97	deleterious	-5.92	high_impact	4.21	0.47	damaging	0.04	damaging	4.50	24.30	deleterious	0.13	0.4	0.9	disease	0.87	disease	0.67	disease	0.8	disease	6	1	deleterious	0.34	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.4	medium_impact	2.64	high_impact	0.88	0.9	26.87	7.04	0.4	N	0.99	polymorphism	0.63	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12649	12649	C	A	MI.19901	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	313	105	L	M	Ctg/Atg	-6.7	0	0	benign	0.29	neutral	0.52	neutral	1.42	neutral	-2.23	neutral	0.28	neutral_impact	0.2	0.85	neutral	0.97	neutral	1.44	13.01	neutral	0.29	0.45	0.52	disease	0.13	neutral	0.41	neutral	0.24	neutral	5	0.38	neutral	0.62	deleterious	-6	neutral	0.67	deleterious	-0.38	medium_impact	0.25	medium_impact	-1.02	low_impact	0.79	0.85	24.21	14.85	0.39	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12649	12649	C	G	MI.19902	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	313	105	L	V	Ctg/Gtg	-6.7	0	0	benign	0.12	neutral	0.46	neutral	1.49	neutral	-0.17	neutral	-1.65	low_impact	1.69	0.89	neutral	0.91	neutral	1.90	15.58	deleterious	0.35	0.5	0.36	neutral	0.35	neutral	0.52	disease	0.47	neutral	1	0.46	neutral	0.67	deleterious	-6	neutral	0.66	deleterious	0.08	medium_impact	0.19	medium_impact	0.34	medium_impact	0.62	0.8	24.21	14.85	0.34	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12650	12650	T	G	MI.19903	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	314	105	L	R	cTg/cGg	-1.42	0	0	probably_damaging	0.95	neutral	0.33	neutral	1.39	neutral	-1.61	deleterious	-4.17	medium_impact	2.34	0.71	neutral	0.54	neutral	3.96	23.60	deleterious	0.24	0.45	0.65	disease	0.8	disease	0.67	disease	0.77	disease	5	0.96	neutral	0.19	neutral	1	deleterious	0.83	deleterious	-1.96	low_impact	0.06	medium_impact	0.94	medium_impact	0.51	0.8	24.21	14.85	0.27	N	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12650	12650	T	C	MI.19904	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	314	105	L	P	cTg/cCg	-1.42	0	0	probably_damaging	0.96	neutral	0.33	neutral	1.38	deleterious	-3.14	deleterious	-5.02	medium_impact	2.34	0.63	neutral	0.44	neutral	3.70	23.30	deleterious	0.18	0.45	0.83	disease	0.81	disease	0.7	disease	0.8	disease	6	0.97	neutral	0.19	neutral	1	deleterious	0.87	deleterious	-2.06	low_impact	0.06	medium_impact	0.94	medium_impact	0.49	0.8	24.21	14.85	0.25	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12650	12650	T	A	MI.19905	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	314	105	L	Q	cTg/cAg	-1.42	0	0	probably_damaging	0.96	neutral	0.27	neutral	1.39	neutral	-2.83	deleterious	-3.72	low_impact	1.23	0.83	neutral	0.77	neutral	4.04	23.70	deleterious	0.27	0.45	0.72	disease	0.53	disease	0.45	neutral	0.5	disease	0	0.97	neutral	0.16	neutral	-2	neutral	0.77	deleterious	-2.06	low_impact	-0.01	medium_impact	-0.08	medium_impact	0.56	0.8	24.21	14.85	0.34	N	0.73	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12652	12652	T	C	MI.19906	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	316	106	W	R	Tga/Cga	-0.96	0	0	probably_damaging	1	neutral	0.36	neutral	1.52	neutral	-0.92	deleterious	-13.81	high_impact	3.92	0.51	damaging	0.07	damaging	3.41	23.00	deleterious	0.48	0.55	0.55	disease	0.91	disease	0.85	disease	0.86	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.1	medium_impact	2.38	high_impact	0.32	0.8	28.36	7.17	0.47	N	0.97	polymorphism	0.97	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12652	12652	T	G	MI.19907	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	316	106	W	G	Tga/Gga	-0.96	0	0	probably_damaging	1	neutral	0.36	neutral	1.61	neutral	1.1	deleterious	-12.82	medium_impact	2.95	0.55	damaging	0.09	damaging	3.73	23.30	deleterious	0.39	0.5	0.41	neutral	0.74	disease	0.82	disease	0.65	disease	3	1	deleterious	0.18	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.1	medium_impact	1.49	medium_impact	0.34	0.8	28.36	7.17	0.37	N	0.97	polymorphism	0.91	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12653	12653	G	T	MI.19908	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	317	106	W	L	tGa/tTa	7.3	1	0	probably_damaging	1	neutral	0.75	neutral	1.5	neutral	-2.59	deleterious	-12.82	high_impact	3.72	0.56	damaging	0.05	damaging	4.15	23.80	deleterious	0.25	0.45	0.58	disease	0.86	disease	0.79	disease	0.8	disease	6	1	deleterious	0.38	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.5	medium_impact	2.2	high_impact	0.22	0.8	28.36	7.17	0.51	P	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12653	12653	G	C	MI.19909	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	317	106	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.45	neutral	1.68	neutral	-0.64	deleterious	-13.81	medium_impact	3.03	0.52	damaging	0.11	damaging	3.91	23.50	deleterious	0.37	0.5	0.51	disease	0.88	disease	0.79	disease	0.64	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.18	medium_impact	1.57	medium_impact	0.32	0.8	28.36	7.17	0.46	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5956	5956	T	G	MI.1991	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	53	18	L	R	cTa/cGa	-0.11	0	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.14	neutral	-2.31	high_impact	4.12	0.61	neutral	0.11	damaging	3.96	23.60	deleterious	0.09	0.55	0.65	disease	0.92	disease	0.7	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.61	0.9	2.92	7.13	0.33	N	0.90	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12654	12654	A	C	MI.19910	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	318	106	W	C	tgA/tgC	5	1	0.01	probably_damaging	1	neutral	0.18	neutral	1.46	deleterious	-4.68	deleterious	-12.82	high_impact	4.27	0.52	damaging	0.06	damaging	3.86	23.50	deleterious	0.27	0.45	0.94	disease	0.91	disease	0.82	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.13	medium_impact	2.7	high_impact	0.24	0.8	28.36	7.17	0.5	N	0.98	disease_causing	1	0.12	rs386829162	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12654	12654	A	T	MI.19911	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	318	106	W	C	tgA/tgT	5	1	0.01	probably_damaging	1	neutral	0.18	neutral	1.46	deleterious	-4.68	deleterious	-12.82	high_impact	4.27	0.52	damaging	0.06	damaging	3.95	23.60	deleterious	0.27	0.45	0.94	disease	0.91	disease	0.82	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.13	medium_impact	2.7	high_impact	0.24	0.8	28.36	7.17	0.51	N	0.98	disease_causing	1	0.12	rs386829162	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12655	12655	T	C	MI.19912	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	319	107	Y	H	Tat/Cat	1.1	1	0	probably_damaging	1	neutral	0.54	neutral	-1.44	deleterious	-9.8	deleterious	-4.93	high_impact	4.42	0.33	damaging	0.32	neutral	3.45	23.00	deleterious	0.4	0.5	0.9	disease	0.82	disease	0.84	disease	0.83	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.27	medium_impact	2.83	high_impact	0.33	0.8	28.03	7.1	0.77	P	0.98	disease_causing	0.96	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12655	12655	T	A	MI.19913	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	319	107	Y	N	Tat/Aat	1.1	1	0	probably_damaging	1	neutral	0.31	neutral	-1.45	deleterious	-10.76	deleterious	-8.88	high_impact	4.42	0.23	damaging	0.42	neutral	3.91	23.50	deleterious	0.29	0.45	0.92	disease	0.86	disease	0.8	disease	0.84	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.04	medium_impact	2.83	high_impact	0.19	0.8	28.03	7.1	0.87	P	0.99	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12655	12655	T	G	MI.19914	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	319	107	Y	D	Tat/Gat	1.1	1	0	probably_damaging	1	neutral	0.21	neutral	-1.45	deleterious	-11.23	deleterious	-9.86	high_impact	4.42	0.38	damaging	0.38	neutral	3.84	23.40	deleterious	0.17	0.45	0.94	disease	0.85	disease	0.86	disease	0.84	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.09	medium_impact	2.83	high_impact	0.34	0.8	28.03	7.1	0.68	P	0.96	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12656	12656	A	T	MI.19915	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	320	107	Y	F	tAt/tTt	4.54	1	0	probably_damaging	1	neutral	0.7	neutral	-1.4	deleterious	-7.53	deleterious	-3.94	high_impact	4.08	0.29	damaging	0.36	neutral	3.07	22.40	deleterious	0.3	0.45	0.8	disease	0.82	disease	0.77	disease	0.79	disease	6	1	deleterious	0.35	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.44	medium_impact	2.52	high_impact	0.43	0.8	28.03	7.1	0.87	P	0.80	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12656	12656	A	C	MI.19916	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	320	107	Y	S	tAt/tCt	4.54	1	0	probably_damaging	1	neutral	0.41	neutral	-1.45	deleterious	-10.51	deleterious	-8.88	high_impact	4.42	0.34	damaging	0.53	neutral	3.39	23.00	deleterious	0.25	0.45	0.76	disease	0.85	disease	0.8	disease	0.77	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.15	medium_impact	2.83	high_impact	0.29	0.8	28.03	7.1	0.7	P	0.97	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12656	12656	A	G	MI.19917	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	320	107	Y	C	tAt/tGt	4.54	1	0	probably_damaging	1	neutral	0.18	neutral	-1.45	deleterious	-11.98	deleterious	-8.88	high_impact	4.42	0.31	damaging	0.28	damaging	3.21	22.70	deleterious	0.36	0.5	0.94	disease	0.88	disease	0.84	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.13	medium_impact	2.83	high_impact	0.17	0.8	28.03	7.1	0.69	P	1.00	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12658	12658	A	G	MI.19918	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	322	108	M	V	Ata/Gta	-1.65	0	0	probably_damaging	0.99	neutral	0.5	neutral	0.15	deleterious	-5.69	deleterious	-3.94	high_impact	3.68	0.41	damaging	0.09	damaging	2.52	19.58	deleterious	0.52	0.6	0.75	disease	0.83	disease	0.74	disease	0.76	disease	5	0.99	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-2.64	low_impact	0.23	medium_impact	2.16	high_impact	0.55	0.8	28.86	7.23	0.38	N	0.95	disease_causing	0.85	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12658	12658	A	C	MI.19919	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	322	108	M	L	Ata/Cta	-1.65	0	0	probably_damaging	0.98	neutral	0.71	neutral	0.28	deleterious	-3.8	deleterious	-2.96	medium_impact	3.48	0.43	damaging	0.07	damaging	3.05	22.40	deleterious	0.42	0.55	0.57	disease	0.82	disease	0.66	disease	0.69	disease	4	0.98	deleterious	0.37	neutral	1	deleterious	0.71	deleterious	-2.35	low_impact	0.45	medium_impact	1.98	medium_impact	0.48	0.8	28.86	7.23	0.33	N	0.98	disease_causing	0.82	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5956	5956	T	C	MI.1992	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	53	18	L	P	cTa/cCa	-0.11	0	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.13	deleterious	-2.73	high_impact	4.33	0.46	damaging	0.14	damaging	3.83	23.40	deleterious	0.1	0.55	0.75	disease	0.88	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.9	high_impact	0.44	0.9	2.92	7.13	0.44	N	0.83	disease_causing	0.95	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12658	12658	A	T	MI.19920	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	322	108	M	L	Ata/Tta	-1.65	0	0	probably_damaging	0.98	neutral	0.71	neutral	0.28	deleterious	-3.8	deleterious	-2.96	medium_impact	3.48	0.43	damaging	0.07	damaging	3.08	22.50	deleterious	0.42	0.55	0.57	disease	0.82	disease	0.66	disease	0.69	disease	4	0.98	deleterious	0.37	neutral	1	deleterious	0.71	deleterious	-2.35	low_impact	0.45	medium_impact	1.98	medium_impact	0.48	0.8	28.86	7.23	0.33	N	0.98	disease_causing	0.82	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12659	12659	T	C	MI.19921	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	323	108	M	T	aTa/aCa	5.46	1	0	probably_damaging	1	neutral	0.38	neutral	0.12	deleterious	-7.49	deleterious	-5.92	high_impact	4.38	0.44	damaging	0.08	damaging	2.83	21.50	deleterious	0.41	0.5	0.76	disease	0.9	disease	0.74	disease	0.78	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.12	medium_impact	2.8	high_impact	0.41	0.8	28.86	7.23	0.55	P	0.99	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12659	12659	T	A	MI.19922	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	323	108	M	K	aTa/aAa	5.46	1	0	probably_damaging	1	neutral	0.29	neutral	0.11	deleterious	-8.61	deleterious	-5.92	high_impact	4.38	0.42	damaging	0.05	damaging	3.76	23.30	deleterious	0.18	0.45	0.82	disease	0.9	disease	0.8	disease	0.84	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.02	medium_impact	2.8	high_impact	0.33	0.8	28.86	7.23	0.62	P	1.00	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12660	12660	A	T	MI.19923	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	324	108	M	I	atA/atT	3.63	1	0	probably_damaging	0.99	neutral	0.46	neutral	0.17	deleterious	-5.31	deleterious	-3.94	medium_impact	3.13	0.43	damaging	0.12	damaging	3.26	22.80	deleterious	0.48	0.55	0.62	disease	0.88	disease	0.72	disease	0.77	disease	5	0.99	deleterious	0.24	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	0.19	medium_impact	1.66	medium_impact	0.69	0.85	28.86	7.23	0.63	P	0.94	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12660	12660	A	C	MI.19924	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	324	108	M	I	atA/atC	3.63	1	0	probably_damaging	0.99	neutral	0.46	neutral	0.17	deleterious	-5.31	deleterious	-3.94	medium_impact	3.13	0.43	damaging	0.12	damaging	3.17	22.70	deleterious	0.48	0.55	0.62	disease	0.88	disease	0.72	disease	0.77	disease	5	0.99	deleterious	0.24	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	0.19	medium_impact	1.66	medium_impact	0.69	0.85	28.86	7.23	0.62	P	0.94	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12661	12661	A	C	MI.19925	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	325	109	N	H	Aac/Cac	-0.5	0	0	benign	0.02	neutral	0.56	neutral	1.63	neutral	0.83	neutral	4.35	neutral_impact	-1.34	0.78	neutral	0.96	neutral	-1.72	0.00	neutral	0.66	0.7	0.45	neutral	0.07	neutral	0.11	neutral	0.26	neutral	5	0.41	neutral	0.77	deleterious	-6	neutral	0.11	neutral	0.86	medium_impact	0.29	medium_impact	-2.43	low_impact	0.49	0.8	17.74	16.94	0.36	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12661	12661	A	G	MI.19926	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	325	109	N	D	Aac/Gac	-0.5	0	0	benign	0.01	neutral	0.21	neutral	1.63	neutral	0.87	neutral	-1.91	low_impact	0.99	0.79	neutral	0.75	neutral	1.78	14.88	neutral	0.81	0.85	0.46	neutral	0.37	neutral	0.42	neutral	0.46	neutral	1	0.79	neutral	0.6	deleterious	-6	neutral	0.15	neutral	1.15	medium_impact	-0.09	medium_impact	-0.3	medium_impact	0.59	0.8	17.74	16.94	0.4	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12661	12661	A	T	MI.19927	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	325	109	N	Y	Aac/Tac	-0.5	0	0	possibly_damaging	0.5	neutral	1	neutral	1.54	neutral	-1.89	neutral	0.04	low_impact	1.34	0.87	neutral	0.94	neutral	1.67	14.26	neutral	0.46	0.55	0.75	disease	0.52	disease	0.23	neutral	0.5	disease	0	0.5	neutral	0.75	deleterious	-3	neutral	0.37	neutral	-0.75	medium_impact	1.89	high_impact	0.02	medium_impact	0.56	0.8	17.74	16.94	0.26	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12662	12662	A	G	MI.19928	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	326	109	N	S	aAc/aGc	-0.73	0	0	benign	0.01	neutral	0.42	neutral	1.73	neutral	1.82	neutral	-1.69	neutral_impact	-0.36	0.83	neutral	0.92	neutral	-0.15	1.37	neutral	0.71	0.75	0.37	neutral	0.21	neutral	0.19	neutral	0.37	neutral	3	0.57	neutral	0.71	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.16	medium_impact	-1.53	low_impact	0.42	0.8	17.74	16.94	0.43	N	0.09	polymorphism	1	0.02	rs879105366	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12662	12662	A	T	MI.19929	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	326	109	N	I	aAc/aTc	-0.73	0	0	possibly_damaging	0.47	neutral	0.4	neutral	1.54	neutral	-1.59	deleterious	-3.9	low_impact	1.59	0.74	neutral	0.68	neutral	1.90	15.58	deleterious	0.49	0.55	0.72	disease	0.68	disease	0.41	neutral	0.51	disease	0	0.56	neutral	0.47	neutral	-3	neutral	0.45	deleterious	-0.7	medium_impact	0.14	medium_impact	0.25	medium_impact	0.41	0.8	17.74	16.94	0.29	N	0.38	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5956	5956	T	A	MI.1993	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	53	18	L	Q	cTa/cAa	-0.11	0	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.21	neutral	-2.26	medium_impact	3.31	0.59	damaging	0.13	damaging	4.06	23.70	deleterious	0.1	0.55	0.5	disease	0.86	disease	0.57	disease	0.72	disease	4	1	deleterious	0	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	1.96	medium_impact	0.61	0.9	2.92	7.13	0.29	N	0.82	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12662	12662	A	C	MI.19930	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	326	109	N	T	aAc/aCc	-0.73	0	0	benign	0.18	neutral	0.39	neutral	1.6	neutral	0.31	deleterious	-2.68	low_impact	1.25	0.85	neutral	0.9	neutral	1.34	12.48	neutral	0.67	0.7	0.62	disease	0.39	neutral	0.41	neutral	0.61	disease	2	0.53	neutral	0.61	deleterious	-6	neutral	0.29	neutral	-0.12	medium_impact	0.13	medium_impact	-0.06	medium_impact	0.54	0.8	17.74	16.94	0.34	N	0.19	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12663	12663	C	A	MI.19931	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	327	109	N	K	aaC/aaA	0.18	0	0	benign	0.18	neutral	0.29	neutral	1.65	neutral	1.1	neutral	-1.72	neutral_impact	0.07	0.79	neutral	0.73	neutral	2.42	18.95	deleterious	0.77	0.8	0.37	neutral	0.49	neutral	0.23	neutral	0.44	neutral	1	0.66	neutral	0.56	deleterious	-6	neutral	0.28	neutral	-0.12	medium_impact	0.02	medium_impact	-1.14	low_impact	0.64	0.8	17.74	16.94	0.34	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12663	12663	C	G	MI.19932	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	327	109	N	K	aaC/aaG	0.18	0	0	benign	0.18	neutral	0.29	neutral	1.65	neutral	1.1	neutral	-1.72	neutral_impact	0.07	0.79	neutral	0.73	neutral	2.02	16.32	deleterious	0.77	0.8	0.37	neutral	0.49	neutral	0.23	neutral	0.44	neutral	1	0.66	neutral	0.56	deleterious	-6	neutral	0.28	neutral	-0.12	medium_impact	0.02	medium_impact	-1.14	low_impact	0.64	0.8	17.74	16.94	0.33	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12664	12664	T	C	MI.19933	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	328	110	S	P	Tca/Cca	-2.11	0	0	probably_damaging	1	neutral	0.2	neutral	1.39	deleterious	-3.33	deleterious	-4.45	medium_impact	3.08	0.72	neutral	0.19	damaging	3.92	23.50	deleterious	0.38	0.5	0.8	disease	0.87	disease	0.43	neutral	0.73	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	-0.1	medium_impact	1.61	medium_impact	0.57	0.8	2.49	9.04	0.34	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12664	12664	T	G	MI.19934	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	328	110	S	A	Tca/Gca	-2.11	0	0	probably_damaging	1	neutral	0.51	neutral	1.45	neutral	-1.38	deleterious	-2.68	low_impact	1.7	0.82	neutral	0.88	neutral	2.20	17.48	deleterious	0.59	0.65	0.67	disease	0.31	neutral	0.2	neutral	0.61	disease	2	1	deleterious	0.26	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.24	medium_impact	0.35	medium_impact	0.74	0.85	2.49	9.04	0.32	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12664	12664	T	A	MI.19935	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	328	110	S	T	Tca/Aca	-2.11	0	0	probably_damaging	1	neutral	0.39	neutral	1.43	neutral	-1.95	deleterious	-2.51	low_impact	1.41	0.83	neutral	0.95	neutral	2.73	21.00	deleterious	0.63	0.65	0.65	disease	0.49	neutral	0.19	neutral	0.55	disease	1	1	deleterious	0.2	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.13	medium_impact	0.09	medium_impact	0.80	0.85	2.49	9.04	0.38	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12665	12665	C	G	MI.19936	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	329	110	S	W	tCa/tGa	-0.5	0	0	probably_damaging	1	neutral	0.19	neutral	1.37	deleterious	-5.86	deleterious	-6.46	high_impact	3.77	0.75	neutral	0.13	damaging	4.25	23.90	deleterious	0.32	0.5	0.97	disease	0.86	disease	0.54	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.12	medium_impact	2.24	high_impact	0.55	0.8	2.49	9.04	0.3	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12665	12665	C	T	MI.19937	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	329	110	S	L	tCa/tTa	-0.5	0	0	probably_damaging	1	neutral	0.65	neutral	1.4	neutral	-2.73	deleterious	-5.42	medium_impact	3.08	0.83	neutral	0.3	neutral	4.56	24.40	deleterious	0.42	0.55	0.81	disease	0.8	disease	0.44	neutral	0.71	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.38	medium_impact	1.61	medium_impact	0.87	0.9	2.49	9.04	0.21	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12667	12667	G	A	MI.19938	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	331	111	D	N	Gac/Aac	-1.65	0	0	probably_damaging	1	neutral	0.32	neutral	0.23	deleterious	-5.64	deleterious	-4.92	high_impact	3.81	0.57	damaging	0.12	damaging	4.08	23.70	deleterious	0.63	0.7	0.73	disease	0.89	disease	0.75	disease	0.79	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.05	medium_impact	2.28	high_impact	0.72	0.85	25.87	7.14	0.35	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12667	12667	G	T	MI.19939	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	331	111	D	Y	Gac/Tac	-1.65	0	0	probably_damaging	1	neutral	1	neutral	0.19	deleterious	-8.83	deleterious	-8.86	high_impact	3.55	0.63	neutral	0.11	damaging	3.78	23.40	deleterious	0.23	0.45	0.88	disease	0.94	disease	0.76	disease	0.83	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.90	deleterious	-3.6	low_impact	1.89	high_impact	2.04	high_impact	0.33	0.8	25.87	7.14	0.32	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5958	5958	T	A	MI.1994	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	55	19	Y	N	Tac/Aac	-20	0	0	probably_damaging	1	deleterious	0	neutral	2	deleterious	-7.45	deleterious	-3.8	high_impact	5	0.64	neutral	0.12	damaging	3.83	23.40	deleterious	0.22	0.55	0.93	disease	0.92	disease	0.69	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.21	0.9	3.51	6.69	0.6	P	0.94	polymorphism	0.9	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12667	12667	G	C	MI.19940	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	331	111	D	H	Gac/Cac	-1.65	0	0	probably_damaging	1	neutral	0.53	neutral	0.2	deleterious	-7.51	deleterious	-6.88	high_impact	4.36	0.61	neutral	0.1	damaging	3.54	23.10	deleterious	0.47	0.55	0.77	disease	0.89	disease	0.8	disease	0.81	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.26	medium_impact	2.78	high_impact	0.57	0.8	25.87	7.14	0.42	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12668	12668	A	G	MI.19941	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	332	111	D	G	gAc/gGc	5.92	1	0	probably_damaging	1	neutral	0.35	neutral	0.21	deleterious	-6.46	deleterious	-6.89	high_impact	4.36	0.58	damaging	0.13	damaging	3.81	23.40	deleterious	0.37	0.5	0.86	disease	0.88	disease	0.76	disease	0.84	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.08	medium_impact	2.78	high_impact	0.36	0.8	25.87	7.14	0.59	P	0.98	disease_causing	0.96	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12668	12668	A	C	MI.19942	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	332	111	D	A	gAc/gCc	5.92	1	0	probably_damaging	1	neutral	0.52	neutral	0.21	deleterious	-6.52	deleterious	-7.87	high_impact	3.81	0.62	neutral	0.18	damaging	3.47	23.00	deleterious	0.31	0.5	0.74	disease	0.87	disease	0.76	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.25	medium_impact	2.28	high_impact	0.49	0.8	25.87	7.14	0.55	P	0.94	disease_causing	0.94	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12668	12668	A	T	MI.19943	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	332	111	D	V	gAc/gTc	5.92	1	0	probably_damaging	1	neutral	0.5	neutral	0.19	deleterious	-8.3	deleterious	-8.86	high_impact	4.36	0.55	damaging	0.1	damaging	3.58	23.20	deleterious	0.27	0.45	0.76	disease	0.93	disease	0.76	disease	0.81	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.23	medium_impact	2.78	high_impact	0.33	0.8	25.87	7.14	0.53	P	0.99	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12669	12669	C	A	MI.19944	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	333	111	D	E	gaC/gaA	8.44	1	0	probably_damaging	1	neutral	0.27	neutral	0.49	neutral	-2.82	deleterious	-3.92	medium_impact	2.79	0.66	neutral	0.25	damaging	4.09	23.70	deleterious	0.54	0.6	0.43	neutral	0.75	disease	0.51	disease	0.49	neutral	0	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	-0.01	medium_impact	1.35	medium_impact	0.57	0.8	25.87	7.14	0.51	P	0.91	disease_causing	0.83	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12669	12669	C	G	MI.19945	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	333	111	D	E	gaC/gaG	8.44	1	0	probably_damaging	1	neutral	0.27	neutral	0.49	neutral	-2.82	deleterious	-3.92	medium_impact	2.79	0.66	neutral	0.25	damaging	3.77	23.40	deleterious	0.54	0.6	0.43	neutral	0.75	disease	0.51	disease	0.49	neutral	0	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	-0.01	medium_impact	1.35	medium_impact	0.57	0.8	25.87	7.14	0.51	P	0.91	disease_causing	0.83	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12670	12670	C	T	MI.19946	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	334	112	P	S	Cca/Tca	-0.96	0	0	probably_damaging	1	neutral	0.42	neutral	1.21	neutral	-2.78	deleterious	-7.53	high_impact	3.58	0.67	neutral	0.11	damaging	3.72	23.30	deleterious	0.52	0.6	0.58	disease	0.83	disease	0.57	disease	0.64	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.16	medium_impact	2.07	high_impact	0.17	0.8	15.26	6.92	0.26	N	0.65	disease_causing	0.96	0.06	rs878876419	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12670	12670	C	A	MI.19947	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	334	112	P	T	Cca/Aca	-0.96	0	0	probably_damaging	1	neutral	0.4	neutral	1.19	deleterious	-3.17	deleterious	-7.5	high_impact	3.73	0.62	neutral	0.1	damaging	3.69	23.30	deleterious	0.4	0.5	0.39	neutral	0.87	disease	0.59	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.14	medium_impact	2.2	high_impact	0.75	0.85	15.26	6.92	0.3	N	0.77	disease_causing	0.96	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12670	12670	C	G	MI.19948	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	334	112	P	A	Cca/Gca	-0.96	0	0	probably_damaging	1	neutral	0.52	neutral	1.21	neutral	-2.82	deleterious	-7.5	high_impact	3.93	0.59	damaging	0.11	damaging	2.94	22.00	deleterious	0.43	0.55	0.67	disease	0.73	disease	0.61	disease	0.65	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.25	medium_impact	2.39	high_impact	0.77	0.85	15.26	6.92	0.27	N	0.64	disease_causing	0.94	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12671	12671	C	A	MI.19949	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	335	112	P	Q	cCa/cAa	2.71	0.13	0	probably_damaging	1	neutral	0.3	neutral	1.2	neutral	-2.95	deleterious	-7.53	high_impact	3.93	0.64	neutral	0.12	damaging	3.98	23.60	deleterious	0.38	0.5	0.67	disease	0.87	disease	0.57	disease	0.65	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.03	medium_impact	2.39	high_impact	0.54	0.8	15.26	6.92	0.4	N	0.86	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5958	5958	T	C	MI.1995	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	55	19	Y	H	Tac/Cac	-20	0	0	probably_damaging	1	deleterious	0	neutral	1.97	deleterious	-6.38	neutral	-2.11	high_impact	4.11	0.7	neutral	0.11	damaging	3.39	23.00	deleterious	0.3	0.55	0.87	disease	0.87	disease	0.71	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.7	high_impact	0.29	0.9	3.51	6.69	0.31	N	0.61	polymorphism	0.99	0.29	.	.	.	.	.	colonic crypt clone	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12671	12671	C	G	MI.19950	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	335	112	P	R	cCa/cGa	2.71	0.13	0	probably_damaging	1	neutral	0.36	neutral	1.19	deleterious	-3.17	deleterious	-8.48	medium_impact	3.48	0.62	neutral	0.09	damaging	3.46	23.00	deleterious	0.42	0.55	0.56	disease	0.92	disease	0.64	disease	0.73	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.1	medium_impact	1.98	medium_impact	0.70	0.85	15.26	6.92	0.37	N	0.88	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12671	12671	C	T	MI.19951	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	335	112	P	L	cCa/cTa	2.71	0.13	0	probably_damaging	1	neutral	0.65	neutral	1.21	neutral	-2.82	deleterious	-9.21	medium_impact	2.75	0.65	neutral	0.46	neutral	4.24	23.90	deleterious	0.42	0.5	0.74	disease	0.89	disease	0.51	disease	0.52	disease	0	1	deleterious	0.33	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.38	medium_impact	1.31	medium_impact	0.75	0.85	15.26	6.92	0.33	N	0.94	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12673	12673	A	G	MI.19952	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	337	113	N	D	Aac/Gac	-11.28	0	0	possibly_damaging	0.89	neutral	0.21	neutral	1.35	neutral	-2.57	deleterious	-3	low_impact	1.8	0.85	neutral	0.78	neutral	2.63	20.40	deleterious	0.82	0.85	0.6	disease	0.55	disease	0.34	neutral	0.5	neutral	0	0.93	neutral	0.16	neutral	-3	neutral	0.72	deleterious	-1.61	low_impact	-0.09	medium_impact	0.44	medium_impact	0.53	0.8	8.46	9.91	0.37	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12673	12673	A	T	MI.19953	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	337	113	N	Y	Aac/Tac	-11.28	0	0	probably_damaging	0.99	neutral	1	neutral	1.37	neutral	-2.05	neutral	-2.36	low_impact	0.94	0.87	neutral	0.98	neutral	1.99	16.14	deleterious	0.48	0.55	0.7	disease	0.47	neutral	0.27	neutral	0.6	disease	2	0.99	deleterious	0.51	deleterious	-2	neutral	0.73	deleterious	-2.64	low_impact	1.89	high_impact	-0.34	medium_impact	0.49	0.8	8.46	9.91	0.27	N	0.18	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12673	12673	A	C	MI.19954	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	337	113	N	H	Aac/Cac	-11.28	0	0	probably_damaging	0.99	neutral	0.54	neutral	1.5	neutral	-0.58	neutral	-1.12	low_impact	1.28	0.83	neutral	0.96	neutral	1.64	14.05	neutral	0.64	0.7	0.53	disease	0.33	neutral	0.31	neutral	0.44	neutral	1	0.99	deleterious	0.28	neutral	-2	neutral	0.69	deleterious	-2.64	low_impact	0.27	medium_impact	-0.03	medium_impact	0.45	0.8	8.46	9.91	0.33	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12674	12674	A	C	MI.19955	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	338	113	N	T	aAc/aCc	-10.6	0	0	probably_damaging	0.94	neutral	0.39	neutral	1.35	neutral	-2.37	deleterious	-3.68	medium_impact	3.01	0.8	neutral	0.62	neutral	3.20	22.70	deleterious	0.63	0.65	0.63	disease	0.62	disease	0.42	neutral	0.51	disease	0	0.94	neutral	0.23	neutral	1	deleterious	0.73	deleterious	-1.88	low_impact	0.13	medium_impact	1.55	medium_impact	0.58	0.8	8.46	9.91	0.3	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12674	12674	A	G	MI.19956	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	338	113	N	S	aAc/aGc	-10.6	0	0	possibly_damaging	0.86	neutral	0.41	neutral	1.37	neutral	-2.05	deleterious	-2.93	medium_impact	2.87	0.82	neutral	0.72	neutral	2.82	21.50	deleterious	0.77	0.8	0.51	disease	0.52	disease	0.43	neutral	0.5	neutral	0	0.86	neutral	0.28	neutral	0	NA	0.72	deleterious	-1.5	low_impact	0.15	medium_impact	1.42	medium_impact	0.24	0.8	8.46	9.91	0.33	N	0.45	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12674	12674	A	T	MI.19957	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	338	113	N	I	aAc/aTc	-10.6	0	0	probably_damaging	0.98	neutral	0.39	neutral	1.32	deleterious	-3.43	deleterious	-5.35	high_impact	3.56	0.8	neutral	0.54	neutral	3.66	23.20	deleterious	0.39	0.5	0.54	disease	0.8	disease	0.45	neutral	0.67	disease	3	0.98	neutral	0.21	neutral	2	deleterious	0.75	deleterious	-2.35	low_impact	0.13	medium_impact	2.05	high_impact	0.32	0.8	8.46	9.91	0.31	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12675	12675	C	G	MI.19958	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	339	113	N	K	aaC/aaG	1.33	0	0	benign	0.26	neutral	0.3	neutral	1.42	neutral	-1.23	deleterious	-3.37	low_impact	1.25	0.88	neutral	0.67	neutral	2.76	21.10	deleterious	0.83	0.85	0.5	neutral	0.63	disease	0.37	neutral	0.48	neutral	0	0.64	neutral	0.52	deleterious	-6	neutral	0.73	deleterious	-0.32	medium_impact	0.03	medium_impact	-0.06	medium_impact	0.67	0.85	8.46	9.91	0.34	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12675	12675	C	A	MI.19959	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	339	113	N	K	aaC/aaA	1.33	0	0	benign	0.26	neutral	0.3	neutral	1.42	neutral	-1.23	deleterious	-3.37	low_impact	1.25	0.88	neutral	0.67	neutral	3.26	22.80	deleterious	0.83	0.85	0.5	neutral	0.63	disease	0.37	neutral	0.48	neutral	0	0.64	neutral	0.52	deleterious	-6	neutral	0.73	deleterious	-0.32	medium_impact	0.03	medium_impact	-0.06	medium_impact	0.67	0.85	8.46	9.91	0.34	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5958	5958	T	G	MI.1996	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	55	19	Y	D	Tac/Gac	-20	0	0	probably_damaging	1	deleterious	0	neutral	1.96	deleterious	-8.49	deleterious	-4.22	high_impact	4.66	0.71	neutral	0.11	damaging	3.74	23.30	deleterious	0.16	0.55	0.96	disease	0.92	disease	0.76	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.22	0.9	3.51	6.69	0.47	N	0.98	polymorphism	0.93	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12676	12676	A	C	MI.19960	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	340	114	I	L	Att/Ctt	-4.4	0	0	possibly_damaging	0.49	neutral	0.7	neutral	1.39	neutral	-1.54	neutral	-1.25	low_impact	1.51	0.76	neutral	0.87	neutral	2.21	17.56	deleterious	0.45	0.55	0.52	disease	0.67	disease	0.33	neutral	0.49	neutral	0	0.4	neutral	0.61	deleterious	-3	neutral	0.69	deleterious	-0.73	medium_impact	0.44	medium_impact	0.18	medium_impact	0.55	0.8	4.98	10.41	0.23	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12676	12676	A	T	MI.19961	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	340	114	I	F	Att/Ttt	-4.4	0	0	probably_damaging	0.94	neutral	0.77	neutral	1.31	deleterious	-3.11	deleterious	-3.42	medium_impact	2.8	0.73	neutral	0.12	damaging	3.42	23.00	deleterious	0.35	0.5	0.63	disease	0.83	disease	0.64	disease	0.73	disease	5	0.94	neutral	0.42	neutral	1	deleterious	0.79	deleterious	-1.88	low_impact	0.52	medium_impact	1.36	medium_impact	0.61	0.8	4.98	10.41	0.16	N	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12676	12676	A	G	MI.19962	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	340	114	I	V	Att/Gtt	-4.4	0	0	possibly_damaging	0.62	neutral	0.5	neutral	1.38	neutral	-1.63	neutral	-0.87	medium_impact	2.52	0.77	neutral	0.31	neutral	1.66	14.18	neutral	0.53	0.6	0.76	disease	0.39	neutral	0.37	neutral	0.65	disease	3	0.6	neutral	0.44	neutral	0	NA	0.70	deleterious	-0.95	medium_impact	0.23	medium_impact	1.1	medium_impact	0.46	0.8	4.98	10.41	0.26	N	0.74	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12677	12677	T	G	MI.19963	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	341	114	I	S	aTt/aGt	3.17	0.99	0	probably_damaging	0.94	neutral	0.42	neutral	1.37	neutral	-1.83	deleterious	-5.27	medium_impact	2.92	0.75	neutral	0.15	damaging	4.15	23.80	deleterious	0.35	0.5	0.7	disease	0.83	disease	0.6	disease	0.69	disease	4	0.93	neutral	0.24	neutral	1	deleterious	0.81	deleterious	-1.88	low_impact	0.16	medium_impact	1.46	medium_impact	0.57	0.8	4.98	10.41	0.34	N	0.96	disease_causing	0.96	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12677	12677	T	A	MI.19964	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	341	114	I	N	aTt/aAt	3.17	0.99	0	probably_damaging	0.98	neutral	0.32	neutral	1.37	neutral	-1.84	deleterious	-6.26	medium_impact	2.75	0.75	neutral	0.17	damaging	4.29	24.00	deleterious	0.37	0.5	0.64	disease	0.88	disease	0.62	disease	0.7	disease	4	0.99	deleterious	0.17	neutral	1	deleterious	0.82	deleterious	-2.35	low_impact	0.05	medium_impact	1.31	medium_impact	0.58	0.8	4.98	10.41	0.36	N	0.99	disease_causing	0.96	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12677	12677	T	C	MI.19965	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	341	114	I	T	aTt/aCt	3.17	0.99	0	probably_damaging	0.94	neutral	0.39	neutral	1.34	neutral	-2.49	deleterious	-4.37	medium_impact	2.75	0.82	neutral	0.18	damaging	3.23	22.80	deleterious	0.35	0.5	0.48	neutral	0.75	disease	0.62	disease	0.56	disease	1	0.94	neutral	0.23	neutral	1	deleterious	0.74	deleterious	-1.88	low_impact	0.13	medium_impact	1.31	medium_impact	0.48	0.8	4.98	10.41	0.33	N	0.96	disease_causing	0.87	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12678	12678	T	A	MI.19966	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	342	114	I	M	atT/atA	2.94	0.99	0	possibly_damaging	0.61	neutral	0.25	neutral	1.35	neutral	-2.12	neutral	-1.92	low_impact	1.87	0.8	neutral	0.82	neutral	1.58	13.73	neutral	0.46	0.55	0.73	disease	0.21	neutral	0.28	neutral	0.52	disease	0	0.76	neutral	0.32	neutral	-3	neutral	0.72	deleterious	-0.93	medium_impact	-0.03	medium_impact	0.51	medium_impact	0.66	0.8	4.98	10.41	0.5	P	0.76	polymorphism	0.75	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12678	12678	T	G	MI.19967	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	342	114	I	M	atT/atG	2.94	0.99	0	possibly_damaging	0.61	neutral	0.25	neutral	1.35	neutral	-2.12	neutral	-1.92	low_impact	1.87	0.8	neutral	0.82	neutral	1.34	12.48	neutral	0.46	0.55	0.73	disease	0.21	neutral	0.28	neutral	0.52	disease	0	0.76	neutral	0.32	neutral	-3	neutral	0.72	deleterious	-0.93	medium_impact	-0.03	medium_impact	0.51	medium_impact	0.66	0.8	4.98	10.41	0.5	P	0.76	polymorphism	0.75	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12679	12679	A	G	MI.19968	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	343	115	N	D	Aat/Gat	-9.91	0	0	benign	0.08	neutral	0.24	neutral	1.52	neutral	-0.77	deleterious	-4	low_impact	1.82	0.84	neutral	0.84	neutral	2.59	20.20	deleterious	0.79	0.8	0.74	disease	0.65	disease	0.39	neutral	0.53	disease	1	0.73	neutral	0.58	deleterious	-6	neutral	0.76	deleterious	0.26	medium_impact	-0.04	medium_impact	0.46	medium_impact	0.63	0.8	17.91	16.66	0.36	N	0.39	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12679	12679	A	T	MI.19969	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	343	115	N	Y	Aat/Tat	-9.91	0	0	probably_damaging	0.98	neutral	1	neutral	1.43	deleterious	-3.41	deleterious	-7.46	high_impact	3.6	0.81	neutral	0.42	neutral	3.58	23.20	deleterious	0.45	0.55	0.75	disease	0.88	disease	0.6	disease	0.71	disease	4	0.98	deleterious	0.51	deleterious	2	deleterious	0.82	deleterious	-2.35	low_impact	1.89	high_impact	2.09	high_impact	0.43	0.8	17.91	16.66	0.24	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5959	5959	A	G	MI.1997	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	56	19	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	1.97	deleterious	-7.48	deleterious	-3.8	high_impact	4.66	0.65	neutral	0.11	damaging	3.29	22.80	deleterious	0.26	0.55	0.97	disease	0.92	disease	0.73	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.19	0.9	3.51	6.69	0.56	P	0.89	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12679	12679	A	C	MI.19970	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	343	115	N	H	Aat/Cat	-9.91	0	0	probably_damaging	0.98	neutral	0.54	neutral	1.44	neutral	-2.63	deleterious	-4.62	medium_impact	2.5	0.85	neutral	0.81	neutral	1.77	14.78	neutral	0.71	0.75	0.77	disease	0.75	disease	0.55	disease	0.58	disease	2	0.98	deleterious	0.28	neutral	1	deleterious	0.79	deleterious	-2.35	low_impact	0.27	medium_impact	1.08	medium_impact	0.46	0.8	17.91	16.66	0.24	N	0.36	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12680	12680	A	C	MI.19971	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	344	115	N	T	aAt/aCt	1.33	0	0	possibly_damaging	0.73	neutral	0.39	neutral	1.59	neutral	0.02	deleterious	-5.47	medium_impact	2.5	0.83	neutral	0.96	neutral	3.31	22.90	deleterious	0.65	0.7	0.6	disease	0.65	disease	0.36	neutral	0.49	neutral	0	0.74	neutral	0.33	neutral	0	NA	0.74	deleterious	-1.16	low_impact	0.13	medium_impact	1.08	medium_impact	0.46	0.8	17.91	16.66	0.32	N	0.65	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12680	12680	A	G	MI.19972	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	344	115	N	S	aAt/aGt	1.33	0	0	benign	0.18	neutral	0.45	neutral	1.6	neutral	0.13	deleterious	-4.48	medium_impact	2.48	0.87	neutral	0.93	neutral	2.98	22.20	deleterious	0.84	0.85	0.6	disease	0.67	disease	0.39	neutral	0.51	disease	0	0.46	neutral	0.64	deleterious	-3	neutral	0.76	deleterious	-0.12	medium_impact	0.18	medium_impact	1.06	medium_impact	0.20	0.8	17.91	16.66	0.34	N	0.65	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12680	12680	A	T	MI.19973	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	344	115	N	I	aAt/aTt	1.33	0	0	probably_damaging	0.96	neutral	0.43	neutral	1.48	neutral	-1.51	deleterious	-8.34	medium_impact	3.25	0.84	neutral	0.54	neutral	3.79	23.40	deleterious	0.42	0.55	0.72	disease	0.9	disease	0.56	disease	0.66	disease	3	0.96	neutral	0.24	neutral	1	deleterious	0.82	deleterious	-2.06	low_impact	0.17	medium_impact	1.77	medium_impact	0.31	0.8	17.91	16.66	0.35	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12681	12681	T	G	MI.19974	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	345	115	N	K	aaT/aaG	2.25	0.01	0.01	possibly_damaging	0.73	neutral	0.29	neutral	1.54	neutral	-0.47	deleterious	-5.49	medium_impact	2.1	0.74	neutral	0.52	neutral	3.89	23.50	deleterious	0.82	0.85	0.49	neutral	0.84	disease	0.61	disease	0.56	disease	1	0.79	neutral	0.28	neutral	0	NA	0.77	deleterious	-1.16	low_impact	0.02	medium_impact	0.72	medium_impact	0.54	0.8	17.91	16.66	0.35	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12681	12681	T	A	MI.19975	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	345	115	N	K	aaT/aaA	2.25	0.01	0.01	possibly_damaging	0.73	neutral	0.29	neutral	1.54	neutral	-0.47	deleterious	-5.49	medium_impact	2.1	0.74	neutral	0.52	neutral	4.17	23.80	deleterious	0.82	0.85	0.49	neutral	0.84	disease	0.61	disease	0.56	disease	1	0.79	neutral	0.28	neutral	0	NA	0.77	deleterious	-1.16	low_impact	0.02	medium_impact	0.72	medium_impact	0.54	0.8	17.91	16.66	0.34	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12682	12682	C	G	MI.19976	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	346	116	Q	E	Cag/Gag	-3.49	0	0	probably_damaging	1	neutral	0.28	neutral	1.57	neutral	-0.26	neutral	-1.12	medium_impact	2.77	0.69	neutral	0.19	damaging	3.00	22.20	deleterious	0.69	0.75	0.33	neutral	0.62	disease	0.63	disease	0.73	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.01	medium_impact	1.33	medium_impact	0.54	0.8	10.61	12.78	0.33	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12682	12682	C	A	MI.19977	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	346	116	Q	K	Cag/Aag	-3.49	0	0	probably_damaging	1	neutral	0.3	neutral	1.66	neutral	0.9	neutral	0.61	neutral_impact	0.19	0.81	neutral	0.92	neutral	2.59	20.10	deleterious	0.65	0.7	0.37	neutral	0.43	neutral	0.39	neutral	0.45	neutral	1	1	deleterious	0.15	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.03	medium_impact	-1.03	low_impact	0.50	0.8	10.61	12.78	0.35	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12683	12683	A	T	MI.19978	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	347	116	Q	L	cAg/cTg	0.87	0	0	probably_damaging	1	neutral	0.66	neutral	1.52	neutral	-1.63	deleterious	-3.36	low_impact	1.41	0.81	neutral	0.41	neutral	3.65	23.20	deleterious	0.53	0.6	0.47	neutral	0.7	disease	0.43	neutral	0.52	disease	0	1	deleterious	0.33	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.39	medium_impact	0.09	medium_impact	0.18	0.8	10.61	12.78	0.19	N	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12683	12683	A	G	MI.19979	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	347	116	Q	R	cAg/cGg	0.87	0	0	probably_damaging	1	neutral	0.35	neutral	2.25	neutral	3.4	neutral	1.6	neutral_impact	-0.86	0.8	neutral	0.94	neutral	0.68	8.69	deleterious	0.7	0.75	0.43	neutral	0.15	neutral	0.37	neutral	0.24	neutral	5	1	deleterious	0.18	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.08	medium_impact	-1.99	low_impact	0.47	0.8	10.61	12.78	0.33	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5959	5959	A	T	MI.1998	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	56	19	Y	F	tAc/tTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.18	deleterious	-3.06	neutral	-1.69	high_impact	4.11	0.52	damaging	0.15	damaging	3.19	22.70	deleterious	0.26	0.55	0.63	disease	0.87	disease	0.62	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.7	high_impact	0.38	0.9	3.51	6.69	0.56	P	0.50	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12683	12683	A	C	MI.19980	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	347	116	Q	P	cAg/cCg	0.87	0	0	probably_damaging	1	neutral	0.21	neutral	1.51	neutral	-2.32	deleterious	-3.2	medium_impact	2.77	0.59	damaging	0.13	damaging	3.24	22.80	deleterious	0.4	0.5	0.63	disease	0.86	disease	0.72	disease	0.81	disease	6	1	deleterious	0.11	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.09	medium_impact	1.33	medium_impact	0.42	0.8	10.61	12.78	0.26	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12684	12684	G	C	MI.19981	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	348	116	Q	H	caG/caC	-0.27	0	0.01	probably_damaging	1	neutral	0.54	neutral	1.55	neutral	-0.86	neutral	-1.75	medium_impact	2.07	0.77	neutral	0.78	neutral	3.42	23.00	deleterious	0.72	0.75	0.74	disease	0.51	disease	0.57	disease	0.69	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.27	medium_impact	0.69	medium_impact	0.70	0.85	10.61	12.78	0.25	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12684	12684	G	T	MI.19982	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	348	116	Q	H	caG/caT	-0.27	0	0.01	probably_damaging	1	neutral	0.54	neutral	1.55	neutral	-0.86	neutral	-1.75	medium_impact	2.07	0.77	neutral	0.78	neutral	3.48	23.10	deleterious	0.72	0.75	0.74	disease	0.51	disease	0.57	disease	0.69	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.27	medium_impact	0.69	medium_impact	0.70	0.85	10.61	12.78	0.25	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12685	12685	T	G	MI.19983	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	349	117	F	V	Ttc/Gtc	-0.96	0	0	probably_damaging	1	neutral	0.52	neutral	-0.13	deleterious	-7.35	deleterious	-6.9	high_impact	4.42	0.4	damaging	0.05	damaging	4.06	23.70	deleterious	0.24	0.45	0.78	disease	0.86	disease	0.77	disease	0.79	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.25	medium_impact	2.83	high_impact	0.56	0.8	27.53	7.12	0.51	P	0.95	polymorphism	0.98	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12685	12685	T	C	MI.19984	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	349	117	F	L	Ttc/Ctc	-0.96	0	0	probably_damaging	1	neutral	0.78	neutral	-0.03	deleterious	-4.73	deleterious	-5.92	high_impact	4.42	0.4	damaging	0.04	damaging	4.08	23.70	deleterious	0.4	0.5	0.73	disease	0.81	disease	0.74	disease	0.75	disease	5	1	deleterious	0.39	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.54	medium_impact	2.83	high_impact	0.80	0.85	27.53	7.12	0.5	N	0.92	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12685	12685	T	A	MI.19985	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	349	117	F	I	Ttc/Atc	-0.96	0	0	probably_damaging	1	neutral	0.41	neutral	-0.13	deleterious	-7.35	deleterious	-5.92	high_impact	4.42	0.42	damaging	0.07	damaging	4.47	24.20	deleterious	0.2	0.45	0.81	disease	0.85	disease	0.76	disease	0.8	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.15	medium_impact	2.83	high_impact	0.58	0.8	27.53	7.12	0.49	N	0.95	polymorphism	0.99	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12686	12686	T	A	MI.19986	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	350	117	F	Y	tTc/tAc	7.3	1	0	probably_damaging	1	neutral	1	neutral	-0.05	deleterious	-5	deleterious	-2.96	high_impact	3.73	0.4	damaging	0.05	damaging	4.20	23.90	deleterious	0.18	0.45	0.62	disease	0.78	disease	0.71	disease	0.72	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.81	deleterious	-3.6	low_impact	1.89	high_impact	2.2	high_impact	0.67	0.85	27.53	7.12	0.62	P	0.88	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12686	12686	T	C	MI.19987	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	350	117	F	S	tTc/tCc	7.3	1	0	probably_damaging	1	neutral	0.4	neutral	-0.14	deleterious	-8.18	deleterious	-7.89	high_impact	4.42	0.44	damaging	0.07	damaging	4.13	23.80	deleterious	0.17	0.45	0.8	disease	0.84	disease	0.75	disease	0.79	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.14	medium_impact	2.83	high_impact	0.41	0.8	27.53	7.12	0.6	P	0.97	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12686	12686	T	G	MI.19988	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	350	117	F	C	tTc/tGc	7.3	1	0	probably_damaging	1	neutral	0.17	neutral	-0.15	deleterious	-9.66	deleterious	-7.89	high_impact	4.42	0.45	damaging	0.04	damaging	4.01	23.60	deleterious	0.18	0.45	0.9	disease	0.86	disease	0.78	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.15	medium_impact	2.83	high_impact	0.35	0.8	27.53	7.12	0.55	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12687	12687	C	G	MI.19989	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	351	117	F	L	ttC/ttG	5.69	1	0	probably_damaging	1	neutral	0.78	neutral	-0.03	deleterious	-4.73	deleterious	-5.92	high_impact	4.42	0.4	damaging	0.04	damaging	4.26	23.90	deleterious	0.4	0.5	0.73	disease	0.81	disease	0.74	disease	0.75	disease	5	1	deleterious	0.39	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.54	medium_impact	2.83	high_impact	0.80	0.85	27.53	7.12	0.68	P	0.92	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5959	5959	A	C	MI.1999	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	56	19	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	1.98	deleterious	-7.01	deleterious	-3.8	high_impact	4.3	0.75	neutral	0.14	damaging	3.51	23.10	deleterious	0.21	0.55	0.92	disease	0.9	disease	0.68	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	2.87	high_impact	0.23	0.9	3.51	6.69	0.52	N	0.90	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12687	12687	C	A	MI.19990	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	351	117	F	L	ttC/ttA	5.69	1	0	probably_damaging	1	neutral	0.78	neutral	-0.03	deleterious	-4.73	deleterious	-5.92	high_impact	4.42	0.4	damaging	0.04	damaging	4.55	24.40	deleterious	0.4	0.5	0.73	disease	0.81	disease	0.74	disease	0.75	disease	5	1	deleterious	0.39	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.54	medium_impact	2.83	high_impact	0.80	0.85	27.53	7.12	0.68	P	0.92	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12688	12688	T	A	MI.19991	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	352	118	F	I	Ttc/Atc	-2.11	0	0	possibly_damaging	0.53	neutral	0.42	neutral	1.31	neutral	-2.88	deleterious	-4.07	low_impact	1.16	0.81	neutral	0.8	neutral	1.48	13.19	neutral	0.26	0.45	0.76	disease	0.73	disease	0.58	disease	0.58	disease	2	0.58	neutral	0.45	neutral	-3	neutral	0.53	deleterious	-0.8	medium_impact	0.16	medium_impact	-0.14	medium_impact	0.68	0.85	18.57	17.25	0.26	N	0.29	polymorphism	0.52	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12688	12688	T	G	MI.19992	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	352	118	F	V	Ttc/Gtc	-2.11	0	0	possibly_damaging	0.53	neutral	0.54	neutral	1.22	neutral	-2.83	deleterious	-5	medium_impact	3.38	0.76	neutral	0.5	neutral	2.28	18.04	deleterious	0.28	0.45	0.82	disease	0.85	disease	0.67	disease	0.74	disease	5	0.5	neutral	0.51	deleterious	0	NA	0.55	deleterious	-0.8	medium_impact	0.27	medium_impact	1.88	medium_impact	0.70	0.85	18.57	17.25	0.27	N	0.71	disease_causing	0.66	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12688	12688	T	C	MI.19993	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	352	118	F	L	Ttc/Ctc	-2.11	0	0	benign	0.03	neutral	0.77	neutral	1.27	neutral	-2.12	deleterious	-3.95	medium_impact	2.02	0.79	neutral	0.68	neutral	0.84	9.70	deleterious	0.46	0.55	0.72	disease	0.78	disease	0.57	disease	0.56	disease	1	0.17	neutral	0.87	deleterious	-3	neutral	0.25	neutral	0.69	medium_impact	0.52	medium_impact	0.64	medium_impact	0.78	0.85	18.57	17.25	0.19	N	0.15	disease_causing	0.5	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12689	12689	T	A	MI.19994	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	353	118	F	Y	tTc/tAc	2.94	0.99	0	possibly_damaging	0.83	neutral	1	neutral	1.19	neutral	-0.48	deleterious	-2.52	medium_impact	2.96	0.79	neutral	0.56	neutral	3.87	23.50	deleterious	0.37	0.5	0.52	disease	0.77	disease	0.58	disease	0.62	disease	2	0.83	neutral	0.59	deleterious	0	NA	0.67	deleterious	-1.4	low_impact	1.89	high_impact	1.5	medium_impact	0.73	0.85	18.57	17.25	0.38	N	0.71	polymorphism	0.95	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12689	12689	T	C	MI.19995	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	353	118	F	S	tTc/tCc	2.94	0.99	0	possibly_damaging	0.89	neutral	0.47	neutral	1.15	deleterious	-4.1	deleterious	-6.52	medium_impact	2.58	0.72	neutral	0.65	neutral	3.99	23.60	deleterious	0.28	0.45	0.71	disease	0.82	disease	0.62	disease	0.59	disease	2	0.89	neutral	0.29	neutral	0	NA	0.75	deleterious	-1.61	low_impact	0.2	medium_impact	1.15	medium_impact	0.58	0.8	18.57	17.25	0.46	N	0.89	polymorphism	0.69	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12689	12689	T	G	MI.19996	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	353	118	F	C	tTc/tGc	2.94	0.99	0	probably_damaging	0.98	neutral	0.17	neutral	1.13	deleterious	-5.34	deleterious	-6.35	medium_impact	3.04	0.76	neutral	0.48	neutral	3.95	23.60	deleterious	0.27	0.45	0.96	disease	0.87	disease	0.69	disease	0.81	disease	6	0.99	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-2.35	low_impact	-0.15	medium_impact	1.57	medium_impact	0.42	0.8	18.57	17.25	0.37	N	0.78	polymorphism	0.59	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12690	12690	C	A	MI.19997	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	354	118	F	L	ttC/ttA	4.31	0.99	0	benign	0.03	neutral	0.77	neutral	1.27	neutral	-2.12	deleterious	-3.95	medium_impact	2.02	0.79	neutral	0.68	neutral	1.53	13.47	neutral	0.46	0.55	0.72	disease	0.78	disease	0.57	disease	0.56	disease	1	0.17	neutral	0.87	deleterious	-3	neutral	0.25	neutral	0.69	medium_impact	0.52	medium_impact	0.64	medium_impact	0.78	0.85	18.57	17.25	0.43	N	0.15	polymorphism	0.56	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12690	12690	C	G	MI.19998	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	354	118	F	L	ttC/ttG	4.31	0.99	0	benign	0.03	neutral	0.77	neutral	1.27	neutral	-2.12	deleterious	-3.95	medium_impact	2.02	0.79	neutral	0.68	neutral	1.21	11.82	neutral	0.46	0.55	0.72	disease	0.78	disease	0.57	disease	0.56	disease	1	0.17	neutral	0.87	deleterious	-3	neutral	0.25	neutral	0.69	medium_impact	0.52	medium_impact	0.64	medium_impact	0.78	0.85	18.57	17.25	0.42	N	0.15	polymorphism	0.56	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12691	12691	A	G	MI.19999	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	355	119	K	E	Aaa/Gaa	-4.63	0	0	probably_damaging	1	neutral	0.26	neutral	1.48	neutral	-0.38	deleterious	-3.81	high_impact	4.24	0.69	neutral	0.15	damaging	3.89	23.50	deleterious	0.42	0.55	0.64	disease	0.85	disease	0.72	disease	0.76	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.02	medium_impact	2.67	high_impact	0.64	0.8	24.71	7.09	0.38	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8527	8527	A	T	MI.2	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	1	1	M	L	Atg/Ttg	2.21	1	0	possibly_damaging	0.52	deleterious	0.02	neutral	4.7	neutral	0.88	neutral	-2.48	NA	NA	0.63	neutral	0.08	damaging	3.94	23.60	deleterious	0.38	0.65	0.68	disease	0.34	neutral	0.63	disease	0.57	disease	1	0.98	neutral	0.25	neutral	3	deleterious	0.51	deleterious	NA	NA	NA	NA	NA	NA	0.50	0.9	50	8.74	0.5	P	0.93	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8535	8535	A	T	MI.20	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	9	3	E	D	gaA/gaT	4.06	1	0	probably_damaging	0.95	neutral	0.24	neutral	4.64	neutral	-0.82	neutral	-1.77	low_impact	1.61	0.84	neutral	0.46	neutral	4.02	23.60	deleterious	0.62	0.7	0.61	disease	0.13	neutral	0.18	neutral	0.41	neutral	2	0.96	neutral	0.15	neutral	-2	neutral	0.64	deleterious	-1.97	low_impact	0.01	medium_impact	0.28	medium_impact	0.92	0.95	15.93	14.48	0.56	P	0.87	polymorphism	0.9	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8620	8620	C	T	MI.200	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	94	32	P	S	Ccc/Tcc	-6.35	0	0	probably_damaging	1	neutral	0.23	neutral	4.45	neutral	1.75	deleterious	-5.83	medium_impact	2.06	0.93	neutral	0.76	neutral	3.66	23.20	deleterious	0.53	0.65	0.47	neutral	0.72	disease	0.36	neutral	0.52	disease	0	1	deleterious	0.12	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.01	medium_impact	0.67	medium_impact	0.12	0.9	29.2	19.38	0.39	N	0.27	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5961	5961	C	A	MI.2000	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	58	20	L	M	Cta/Ata	-2.42	0	0	probably_damaging	1	neutral	0.08	neutral	2.59	neutral	-2.07	neutral	-0.29	low_impact	1.7	0.72	neutral	0.84	neutral	0.93	10.25	neutral	0.19	0.55	0.65	disease	0.61	disease	0.28	neutral	0.5	neutral	0	1	deleterious	0.04	neutral	-2	neutral	0.78	deleterious	-3.58	low_impact	-0.4	medium_impact	0.47	medium_impact	0.57	0.9	10.14	14.27	0.44	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12691	12691	A	C	MI.20000	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	355	119	K	Q	Aaa/Caa	-4.63	0	0	probably_damaging	1	neutral	0.28	neutral	1.47	neutral	-0.78	deleterious	-3.73	high_impact	3.68	0.77	neutral	0.18	damaging	3.33	22.90	deleterious	0.5	0.6	0.49	neutral	0.75	disease	0.53	disease	0.61	disease	2	1	deleterious	0.14	neutral	2	deleterious	0.74	deleterious	-3.6	low_impact	0.01	medium_impact	2.16	high_impact	0.60	0.8	24.71	7.09	0.29	N	0.82	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12692	12692	A	T	MI.20001	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	356	119	K	M	aAa/aTa	4.54	0.99	0	probably_damaging	1	neutral	0.31	neutral	1.45	neutral	-0.35	deleterious	-5.39	medium_impact	3.19	0.8	neutral	0.16	damaging	3.85	23.40	deleterious	0.32	0.5	0.64	disease	0.74	disease	0.52	disease	0.55	disease	1	1	deleterious	0.16	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.04	medium_impact	1.71	medium_impact	0.54	0.8	24.71	7.09	0.43	N	0.40	polymorphism	0.54	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12692	12692	A	C	MI.20002	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	356	119	K	T	aAa/aCa	4.54	0.99	0	probably_damaging	1	neutral	0.38	neutral	1.5	neutral	0.8	deleterious	-5.63	high_impact	3.68	0.71	neutral	0.25	damaging	3.59	23.20	deleterious	0.31	0.45	0.64	disease	0.74	disease	0.54	disease	0.54	disease	1	1	deleterious	0.19	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.12	medium_impact	2.16	high_impact	0.43	0.8	24.71	7.09	0.46	N	0.75	polymorphism	0.73	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12693	12693	A	C	MI.20003	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	357	119	K	N	aaA/aaC	4.54	0.99	0	probably_damaging	1	neutral	0.31	neutral	1.46	neutral	-1.24	deleterious	-4.75	medium_impact	2.56	0.73	neutral	0.19	damaging	3.62	23.20	deleterious	0.55	0.6	0.69	disease	0.75	disease	0.54	disease	0.58	disease	1	1	deleterious	0.16	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.04	medium_impact	1.14	medium_impact	0.63	0.8	24.71	7.09	0.46	N	0.63	polymorphism	0.6	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12693	12693	A	T	MI.20004	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	357	119	K	N	aaA/aaT	4.54	0.99	0	probably_damaging	1	neutral	0.31	neutral	1.46	neutral	-1.24	deleterious	-4.75	medium_impact	2.56	0.73	neutral	0.19	damaging	3.73	23.30	deleterious	0.55	0.6	0.69	disease	0.75	disease	0.54	disease	0.58	disease	1	1	deleterious	0.16	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.04	medium_impact	1.14	medium_impact	0.63	0.8	24.71	7.09	0.47	N	0.63	polymorphism	0.6	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12694	12694	T	C	MI.20005	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	358	120	Y	H	Tat/Cat	-0.27	0.43	0	probably_damaging	0.98	neutral	0.48	neutral	0.91	deleterious	-5.93	deleterious	-4.93	medium_impact	2.94	0.62	neutral	0.68	neutral	3.53	23.10	deleterious	0.32	0.5	0.94	disease	0.84	disease	0.7	disease	0.79	disease	6	0.98	neutral	0.25	neutral	1	deleterious	0.83	deleterious	-2.35	low_impact	0.21	medium_impact	1.48	medium_impact	0.57	0.8	17.74	7.05	0.3	N	0.88	disease_causing	0.88	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12694	12694	T	A	MI.20006	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	358	120	Y	N	Tat/Aat	-0.27	0.43	0	probably_damaging	0.98	neutral	0.35	neutral	0.91	deleterious	-5.84	deleterious	-8.88	high_impact	4.29	0.67	neutral	0.44	neutral	4.09	23.70	deleterious	0.29	0.45	0.94	disease	0.89	disease	0.64	disease	0.81	disease	6	0.98	neutral	0.19	neutral	2	deleterious	0.83	deleterious	-2.35	low_impact	0.08	medium_impact	2.72	high_impact	0.43	0.8	17.74	7.05	0.42	N	0.92	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12694	12694	T	G	MI.20007	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	358	120	Y	D	Tat/Gat	-0.27	0.43	0	probably_damaging	0.98	neutral	0.2	neutral	0.91	deleterious	-6.57	deleterious	-9.86	high_impact	4.29	0.69	neutral	0.38	neutral	3.79	23.40	deleterious	0.19	0.45	0.96	disease	0.89	disease	0.76	disease	0.85	disease	7	0.99	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-2.35	low_impact	-0.1	medium_impact	2.72	high_impact	0.42	0.8	17.74	7.05	0.46	N	0.94	disease_causing	0.98	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12695	12695	A	T	MI.20008	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	359	120	Y	F	tAt/tTt	4.54	1	0	benign	0.12	neutral	0.73	neutral	0.95	deleterious	-4.06	deleterious	-3.94	medium_impact	3.01	0.72	neutral	0.66	neutral	1.18	11.64	neutral	0.32	0.5	0.62	disease	0.81	disease	0.59	disease	0.52	disease	0	0.16	neutral	0.81	deleterious	-3	neutral	0.29	neutral	0.08	medium_impact	0.47	medium_impact	1.55	medium_impact	0.65	0.8	17.74	7.05	0.45	N	0.26	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12695	12695	A	G	MI.20009	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	359	120	Y	C	tAt/tGt	4.54	1	0	probably_damaging	0.98	neutral	0.15	neutral	0.91	deleterious	-6.16	deleterious	-8.88	high_impact	4.29	0.67	neutral	0.31	neutral	3.31	22.90	deleterious	0.3	0.45	0.94	disease	0.89	disease	0.72	disease	0.83	disease	7	0.99	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-2.35	low_impact	-0.18	medium_impact	2.72	high_impact	0.34	0.8	17.74	7.05	0.48	N	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5961	5961	C	G	MI.2001	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	58	20	L	V	Cta/Gta	-2.42	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.73	neutral	-0.51	neutral	-0.71	medium_impact	2.77	0.62	neutral	0.45	neutral	1.52	13.43	neutral	0.17	0.55	0.51	disease	0.73	disease	0.51	disease	0.58	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-2.64	low_impact	-0.92	medium_impact	1.46	medium_impact	0.55	0.9	10.14	14.27	0.36	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12695	12695	A	C	MI.20010	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	359	120	Y	S	tAt/tCt	4.54	1	0	probably_damaging	0.97	neutral	0.38	neutral	0.93	deleterious	-4.78	deleterious	-8.88	high_impact	3.94	0.69	neutral	0.48	neutral	3.35	22.90	deleterious	0.28	0.45	0.85	disease	0.86	disease	0.68	disease	0.78	disease	6	0.97	neutral	0.21	neutral	2	deleterious	0.79	deleterious	-2.18	low_impact	0.12	medium_impact	2.4	high_impact	0.54	0.8	17.74	7.05	0.51	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12697	12697	C	A	MI.20011	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	361	121	L	M	Cta/Ata	-4.86	0	0	probably_damaging	1	neutral	0.24	neutral	0.86	deleterious	-3.29	neutral	-1.91	medium_impact	3.5	0.51	damaging	0.14	damaging	3.74	23.30	deleterious	0.3	0.45	0.73	disease	0.6	disease	0.51	disease	0.53	disease	1	1	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.04	medium_impact	1.99	medium_impact	0.70	0.85	28.03	7.23	0.37	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12697	12697	C	G	MI.20012	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	361	121	L	V	Cta/Gta	-4.86	0	0	probably_damaging	1	neutral	0.52	neutral	0.88	deleterious	-3.08	deleterious	-2.91	medium_impact	3.36	0.43	damaging	0.1	damaging	3.24	22.80	deleterious	0.23	0.45	0.73	disease	0.62	disease	0.65	disease	0.59	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.25	medium_impact	1.87	medium_impact	0.57	0.8	28.03	7.23	0.33	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12698	12698	T	A	MI.20013	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	362	121	L	Q	cTa/cAa	-0.73	0	0	probably_damaging	1	neutral	0.29	neutral	0.76	deleterious	-6.03	deleterious	-5.7	high_impact	4.39	0.45	damaging	0.1	damaging	3.86	23.50	deleterious	0.13	0.4	0.92	disease	0.79	disease	0.67	disease	0.8	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.02	medium_impact	2.81	high_impact	0.69	0.85	28.03	7.23	0.39	N	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12698	12698	T	G	MI.20014	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	362	121	L	R	cTa/cGa	-0.73	0	0	probably_damaging	1	neutral	0.43	neutral	0.76	deleterious	-5.9	deleterious	-5.77	high_impact	4.39	0.53	damaging	0.08	damaging	3.97	23.60	deleterious	0.11	0.4	0.94	disease	0.91	disease	0.77	disease	0.85	disease	7	1	deleterious	0.22	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.17	medium_impact	2.81	high_impact	0.48	0.8	28.03	7.23	0.43	N	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12698	12698	T	C	MI.20015	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	362	121	L	P	cTa/cCa	-0.73	0	0	probably_damaging	1	neutral	0.19	neutral	0.76	deleterious	-6.48	deleterious	-6.77	high_impact	4.39	0.46	damaging	0.09	damaging	3.73	23.30	deleterious	0.11	0.4	0.96	disease	0.81	disease	0.76	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.12	medium_impact	2.81	high_impact	0.66	0.8	28.03	7.23	0.42	N	0.99	polymorphism	0.78	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12700	12700	C	T	MI.20016	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	364	122	L	F	Ctc/Ttc	-9.91	0	0	probably_damaging	1	neutral	0.76	neutral	1.44	deleterious	-3.04	deleterious	-3.87	medium_impact	3	0.68	neutral	0.09	damaging	3.87	23.50	deleterious	0.35	0.5	0.9	disease	0.74	disease	0.62	disease	0.76	disease	5	1	deleterious	0.38	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.51	medium_impact	1.54	medium_impact	0.73	0.85	19.57	16.92	0.17	N	0.52	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12700	12700	C	A	MI.20017	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	364	122	L	I	Ctc/Atc	-9.91	0	0	probably_damaging	1	neutral	0.27	neutral	1.56	deleterious	-3.02	neutral	-1.83	low_impact	1.78	0.79	neutral	0.67	neutral	2.86	21.70	deleterious	0.34	0.5	0.74	disease	0.61	disease	0.53	disease	0.52	disease	0	1	deleterious	0.14	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	-0.01	medium_impact	0.42	medium_impact	0.81	0.85	19.57	16.92	0.31	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12700	12700	C	G	MI.20018	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	364	122	L	V	Ctc/Gtc	-9.91	0	0	probably_damaging	1	neutral	0.24	neutral	1.48	neutral	-2.54	deleterious	-2.81	medium_impact	2.9	0.7	neutral	0.09	damaging	3.28	22.80	deleterious	0.37	0.5	0.8	disease	0.61	disease	0.55	disease	0.61	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	-0.04	medium_impact	1.45	medium_impact	0.68	0.85	19.57	16.92	0.24	N	0.16	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12701	12701	T	C	MI.20019	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	365	122	L	P	cTc/cCc	-0.27	0	0	probably_damaging	1	neutral	0.09	neutral	1.43	deleterious	-4.7	deleterious	-6.82	high_impact	4.04	0.63	neutral	0.09	damaging	3.84	23.40	deleterious	0.06	0.35	0.9	disease	0.86	disease	0.73	disease	0.82	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.32	medium_impact	2.49	high_impact	0.66	0.8	19.57	16.92	0.32	N	0.93	disease_causing	0.6	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5962	5962	T	C	MI.2002	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	59	20	L	P	cTa/cCa	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.51	neutral	-2.2	high_impact	3.82	0.6	damaging	0.33	neutral	3.73	23.30	deleterious	0.11	0.55	0.89	disease	0.94	disease	0.64	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.58	low_impact	-1.48	low_impact	2.43	high_impact	0.49	0.9	10.14	14.27	0.3	N	0.83	polymorphism	0.9	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12701	12701	T	G	MI.20020	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	365	122	L	R	cTc/cGc	-0.27	0	0	probably_damaging	1	neutral	0.14	neutral	1.45	deleterious	-5.44	deleterious	-5.86	high_impact	4.04	0.64	neutral	0.09	damaging	4.05	23.70	deleterious	0.08	0.35	0.9	disease	0.92	disease	0.73	disease	0.83	disease	7	1	deleterious	0.07	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.2	medium_impact	2.49	high_impact	0.62	0.8	19.57	16.92	0.31	N	0.91	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12701	12701	T	A	MI.20021	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	365	122	L	H	cTc/cAc	-0.27	0	0	probably_damaging	1	neutral	0.21	neutral	1.43	deleterious	-4.72	deleterious	-6.82	high_impact	4.04	0.68	neutral	0.09	damaging	4.13	23.80	deleterious	0.09	0.35	0.9	disease	0.82	disease	0.7	disease	0.79	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.09	medium_impact	2.49	high_impact	0.71	0.85	19.57	16.92	0.31	N	0.82	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12703	12703	A	T	MI.20022	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	367	123	I	F	Atc/Ttc	-12.66	0	0	possibly_damaging	0.88	neutral	0.67	neutral	1.52	neutral	0.11	neutral	-1.69	low_impact	1.9	0.8	neutral	0.79	neutral	3.63	23.20	deleterious	0.38	0.5	0.51	disease	0.7	disease	0.59	disease	0.68	disease	4	0.86	neutral	0.4	neutral	-3	neutral	0.73	deleterious	-1.57	low_impact	0.4	medium_impact	0.53	medium_impact	0.72	0.85	22.22	17.52	0.2	N	0.37	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12703	12703	A	G	MI.20023	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	367	123	I	V	Atc/Gtc	-12.66	0	0	benign	0.09	neutral	0.53	neutral	1.52	neutral	-0.38	neutral	-0.56	low_impact	1.81	0.75	neutral	0.77	neutral	1.77	14.80	neutral	0.49	0.55	0.6	disease	0.28	neutral	0.37	neutral	0.55	disease	1	0.39	neutral	0.72	deleterious	-6	neutral	0.66	deleterious	0.21	medium_impact	0.26	medium_impact	0.45	medium_impact	0.52	0.8	22.22	17.52	0.31	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12703	12703	A	C	MI.20024	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	367	123	I	L	Atc/Ctc	-12.66	0	0	benign	0.3	neutral	1	neutral	1.7	neutral	2.12	neutral	0.9	neutral_impact	0.16	0.81	neutral	0.97	neutral	0.94	10.30	neutral	0.28	0.45	0.36	neutral	0.25	neutral	0.28	neutral	0.46	neutral	1	0.3	neutral	0.85	deleterious	-6	neutral	0.62	deleterious	-0.4	medium_impact	1.89	high_impact	-1.06	low_impact	0.65	0.8	22.22	17.52	0.31	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12704	12704	T	C	MI.20025	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	368	123	I	T	aTc/aCc	-2.8	0	0	benign	0.09	neutral	0.27	neutral	1.51	neutral	-1.69	neutral	-2.21	low_impact	0.9	0.86	neutral	0.98	neutral	1.69	14.35	neutral	0.39	0.5	0.64	disease	0.28	neutral	0.37	neutral	0.56	disease	1	0.7	neutral	0.59	deleterious	-6	neutral	0.70	deleterious	0.21	medium_impact	-0.01	medium_impact	-0.38	medium_impact	0.66	0.8	22.22	17.52	0.36	N	0.30	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12704	12704	T	G	MI.20026	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	368	123	I	S	aTc/aGc	-2.8	0	0	possibly_damaging	0.66	neutral	0.22	neutral	1.46	neutral	-2.41	deleterious	-3.19	medium_impact	2.88	0.85	neutral	0.6	neutral	4.15	23.80	deleterious	0.3	0.45	0.76	disease	0.71	disease	0.55	disease	0.68	disease	4	0.81	neutral	0.28	neutral	0	NA	0.75	deleterious	-1.02	low_impact	-0.07	medium_impact	1.43	medium_impact	0.55	0.8	22.22	17.52	0.31	N	0.39	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12704	12704	T	A	MI.20027	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	368	123	I	N	aTc/aAc	-2.8	0	0	probably_damaging	0.91	neutral	0.14	neutral	1.4	deleterious	-3.83	deleterious	-4.18	medium_impact	3.23	0.73	neutral	0.38	neutral	4.30	24.00	deleterious	0.26	0.45	0.91	disease	0.76	disease	0.59	disease	0.78	disease	6	0.96	neutral	0.12	neutral	1	deleterious	0.80	deleterious	-1.7	low_impact	-0.2	medium_impact	1.75	medium_impact	0.71	0.85	22.22	17.52	0.32	N	0.79	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12705	12705	C	A	MI.20028	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	369	123	I	M	atC/atA	-0.27	0	0.88	benign	0.41	neutral	0.13	neutral	1.48	neutral	-0.98	neutral	0.5	neutral_impact	0.58	0.84	neutral	0.98	neutral	1.64	14.09	neutral	0.39	0.5	0.5	disease	0.23	neutral	0.3	neutral	0.2	neutral	6	0.85	neutral	0.36	neutral	-6	neutral	0.67	deleterious	-0.6	medium_impact	-0.22	medium_impact	-0.67	medium_impact	0.82	0.85	22.22	17.52	0.44	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12705	12705	C	G	MI.20029	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	369	123	I	M	atC/atG	-0.27	0	0.88	benign	0.41	neutral	0.13	neutral	1.48	neutral	-0.98	neutral	0.5	neutral_impact	0.58	0.84	neutral	0.98	neutral	1.21	11.81	neutral	0.39	0.5	0.5	disease	0.23	neutral	0.3	neutral	0.2	neutral	6	0.85	neutral	0.36	neutral	-6	neutral	0.67	deleterious	-0.6	medium_impact	-0.22	medium_impact	-0.67	medium_impact	0.82	0.85	22.22	17.52	0.44	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5962	5962	T	A	MI.2003	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	59	20	L	Q	cTa/cAa	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-4.11	neutral	-1.77	high_impact	3.82	0.67	neutral	0.41	neutral	3.87	23.50	deleterious	0.14	0.55	0.85	disease	0.86	disease	0.52	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.43	high_impact	0.65	0.9	10.14	14.27	0.35	N	0.82	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12706	12706	T	C	MI.20030	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	370	124	F	L	Ttc/Ctc	-5.55	0	0	probably_damaging	1	neutral	1	neutral	3.25	neutral	-2.08	deleterious	-5.92	high_impact	5	0.07	damaging	0.5	neutral	3.92	23.50	deleterious	0.35	0.5	0.64	disease	0.86	disease	0.66	disease	0.72	disease	4	0.99	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.6	low_impact	1.89	high_impact	3.36	high_impact	0.56	0.8	27.86	7.15	0.9	P	0.91	disease_causing_automatic	0.02	0.27	rs267606893	Pathogenic	Leigh_syndrome|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency	24737	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838951	.	.	.	.	T12706C	Leigh Disease	-	+	Cfrm	10	P	P	P	damaging
chrM	12706	12706	T	G	MI.20031	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	370	124	F	V	Ttc/Gtc	-5.55	0	0	probably_damaging	1	neutral	0.61	neutral	3.14	deleterious	-3.6	deleterious	-6.9	high_impact	5	0.21	damaging	0.43	neutral	3.93	23.50	deleterious	0.28	0.45	0.68	disease	0.89	disease	0.72	disease	0.77	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.34	medium_impact	3.36	high_impact	0.63	0.8	27.86	7.15	0.87	P	0.94	polymorphism	0.95	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12706	12706	T	A	MI.20032	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	370	124	F	I	Ttc/Atc	-5.55	0	0	probably_damaging	1	neutral	0.56	neutral	3.13	deleterious	-3.75	deleterious	-5.92	high_impact	5	0.29	damaging	0.58	neutral	4.25	23.90	deleterious	0.19	0.45	0.78	disease	0.87	disease	0.71	disease	0.75	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.29	medium_impact	3.36	high_impact	0.56	0.8	27.86	7.15	0.87	P	0.95	polymorphism	0.98	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12707	12707	T	G	MI.20033	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	371	124	F	C	tTc/tGc	5.69	1	0	probably_damaging	1	neutral	0.18	neutral	3.08	deleterious	-5.35	deleterious	-7.89	high_impact	5	0.29	damaging	0.45	neutral	3.99	23.60	deleterious	0.25	0.45	0.9	disease	0.88	disease	0.73	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.13	medium_impact	3.36	high_impact	0.42	0.8	27.86	7.15	0.9	P	0.99	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12707	12707	T	C	MI.20034	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	371	124	F	S	tTc/tCc	5.69	1	0	probably_damaging	1	neutral	0.55	neutral	3.15	deleterious	-3.67	deleterious	-7.89	high_impact	4.3	0.31	damaging	0.57	neutral	4.13	23.80	deleterious	0.26	0.45	0.85	disease	0.86	disease	0.69	disease	0.78	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.28	medium_impact	2.73	high_impact	0.58	0.8	27.86	7.15	0.79	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12707	12707	T	A	MI.20035	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	371	124	F	Y	tTc/tAc	5.69	1	0	probably_damaging	1	neutral	0.83	neutral	3.09	deleterious	-5.25	deleterious	-2.96	high_impact	5	0.31	damaging	0.43	neutral	4.13	23.80	deleterious	0.21	0.45	0.64	disease	0.83	disease	0.68	disease	0.7	disease	4	0.99	deleterious	0.42	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.61	medium_impact	3.36	high_impact	0.59	0.8	27.86	7.15	0.84	P	0.88	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12708	12708	C	G	MI.20036	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	372	124	F	L	ttC/ttG	5.69	1	0	probably_damaging	1	neutral	1	neutral	3.25	neutral	-2.08	deleterious	-5.92	high_impact	5	0.07	damaging	0.5	neutral	4.24	23.90	deleterious	0.35	0.5	0.64	disease	0.86	disease	0.66	disease	0.72	disease	4	0.99	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.6	low_impact	1.89	high_impact	3.36	high_impact	0.56	0.8	27.86	7.15	0.95	P	0.91	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12708	12708	C	A	MI.20037	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	372	124	F	L	ttC/ttA	5.69	1	0	probably_damaging	1	neutral	1	neutral	3.25	neutral	-2.08	deleterious	-5.92	high_impact	5	0.07	damaging	0.5	neutral	4.57	24.40	deleterious	0.35	0.5	0.64	disease	0.86	disease	0.66	disease	0.72	disease	4	0.99	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.6	low_impact	1.89	high_impact	3.36	high_impact	0.56	0.8	27.86	7.15	0.95	P	0.91	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12709	12709	C	G	MI.20038	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	373	125	L	V	Cta/Gta	-1.65	0	0	probably_damaging	1	neutral	0.5	neutral	3.66	neutral	-0.71	deleterious	-2.96	low_impact	1.92	0.5	damaging	0.04	damaging	3.27	22.80	deleterious	0.6	0.65	0.61	disease	0.7	disease	0.66	disease	0.62	disease	2	1	deleterious	0.25	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.23	medium_impact	0.55	medium_impact	0.50	0.8	28.69	7.2	0.22	N	0.78	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12709	12709	C	A	MI.20039	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	373	125	L	M	Cta/Ata	-1.65	0	0	probably_damaging	1	neutral	0.32	neutral	3.56	neutral	-1.54	neutral	-1.97	low_impact	1.72	0.56	damaging	0.06	damaging	3.60	23.20	deleterious	0.38	0.5	0.59	disease	0.67	disease	0.65	disease	0.66	disease	3	1	deleterious	0.16	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.05	medium_impact	0.37	medium_impact	0.44	0.8	28.69	7.2	0.24	N	0.85	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5962	5962	T	G	MI.2004	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	59	20	L	R	cTa/cGa	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.94	neutral	-1.78	high_impact	3.82	0.61	neutral	0.29	neutral	3.97	23.60	deleterious	0.12	0.55	0.85	disease	0.95	disease	0.64	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.58	low_impact	-1.48	low_impact	2.43	high_impact	0.61	0.9	10.14	14.27	0.32	N	0.90	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12710	12710	T	G	MI.20040	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	374	125	L	R	cTa/cGa	-0.27	0	0	probably_damaging	1	neutral	0.13	neutral	3.47	deleterious	-4.74	deleterious	-5.92	high_impact	4.35	0.54	damaging	0.04	damaging	4.02	23.60	deleterious	0.21	0.45	0.91	disease	0.94	disease	0.77	disease	0.88	disease	8	1	deleterious	0.07	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.22	medium_impact	2.77	high_impact	0.51	0.8	28.69	7.2	0.43	N	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12710	12710	T	C	MI.20041	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	374	125	L	P	cTa/cCa	-0.27	0	0	probably_damaging	1	neutral	0.08	neutral	3.47	deleterious	-5.39	deleterious	-6.91	high_impact	4.35	0.5	damaging	0.04	damaging	3.78	23.40	deleterious	0.17	0.45	0.64	disease	0.88	disease	0.78	disease	0.81	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.35	medium_impact	2.77	high_impact	0.59	0.8	28.69	7.2	0.42	N	0.99	polymorphism	0.85	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12710	12710	T	A	MI.20042	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	374	125	L	Q	cTa/cAa	-0.27	0	0	probably_damaging	1	neutral	0.13	neutral	3.49	deleterious	-3.25	deleterious	-5.92	high_impact	4.35	0.48	damaging	0.03	damaging	3.95	23.60	deleterious	0.25	0.45	0.84	disease	0.84	disease	0.67	disease	0.76	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.22	medium_impact	2.77	high_impact	0.59	0.8	28.69	7.2	0.38	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12712	12712	A	T	MI.20043	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	376	126	I	F	Att/Ttt	-7.84	0	0	benign	0.36	neutral	0.38	neutral	3.85	neutral	0.78	deleterious	-3.81	neutral_impact	0.56	0.81	neutral	0.71	neutral	0.90	10.07	neutral	0.55	0.6	0.38	neutral	0.65	disease	0.5	neutral	0.47	neutral	1	0.55	neutral	0.51	deleterious	-6	neutral	0.50	deleterious	-0.51	medium_impact	0.12	medium_impact	-0.69	medium_impact	0.70	0.85	20.07	17.52	0.27	N	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12712	12712	A	G	MI.20044	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	376	126	I	V	Att/Gtt	-7.84	0	0	benign	0.01	neutral	0.36	neutral	3.79	neutral	0.14	neutral	-0.89	low_impact	1.19	0.81	neutral	0.83	neutral	-0.59	0.13	neutral	0.71	0.75	0.63	disease	0.29	neutral	0.33	neutral	0.56	disease	1	0.63	neutral	0.68	deleterious	-6	neutral	0.20	neutral	1.15	medium_impact	0.1	medium_impact	-0.12	medium_impact	0.52	0.8	20.07	17.52	0.34	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12712	12712	A	C	MI.20045	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	376	126	I	L	Att/Ctt	-7.84	0	0	benign	0.05	neutral	1	neutral	3.9	neutral	0.85	neutral	-1.85	low_impact	0.99	0.8	neutral	0.75	neutral	0.60	8.15	deleterious	0.39	0.5	0.48	neutral	0.59	disease	0.34	neutral	0.47	neutral	1	0.05	neutral	0.98	deleterious	-6	neutral	0.19	neutral	0.47	medium_impact	1.89	high_impact	-0.3	medium_impact	0.59	0.8	20.07	17.52	0.2	N	0.35	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12713	12713	T	A	MI.20046	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	377	126	I	N	aTt/aAt	0.18	0	0	possibly_damaging	0.47	neutral	0.1	neutral	3.67	deleterious	-3.31	deleterious	-6.66	high_impact	3.62	0.82	neutral	0.37	neutral	2.60	20.20	deleterious	0.44	0.55	0.86	disease	0.87	disease	0.6	disease	0.77	disease	5	0.89	neutral	0.32	neutral	1	deleterious	0.61	deleterious	-0.7	medium_impact	-0.29	medium_impact	2.1	high_impact	0.54	0.8	20.07	17.52	0.36	N	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12713	12713	T	G	MI.20047	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	377	126	I	S	aTt/aGt	0.18	0	0	benign	0.19	neutral	0.31	neutral	3.75	neutral	-0.21	deleterious	-5.67	medium_impact	2.04	0.71	neutral	0.37	neutral	2.25	17.87	deleterious	0.46	0.55	0.6	disease	0.84	disease	0.57	disease	0.72	disease	4	0.63	neutral	0.56	deleterious	-3	neutral	0.36	neutral	-0.15	medium_impact	0.04	medium_impact	0.66	medium_impact	0.50	0.8	20.07	17.52	0.27	N	0.86	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12713	12713	T	C	MI.20048	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	377	126	I	T	aTt/aCt	0.18	0	0	benign	0.01	neutral	0.13	neutral	3.78	neutral	-0.07	deleterious	-4.67	low_impact	1.41	0.84	neutral	0.56	neutral	1.30	12.28	neutral	0.58	0.65	0.59	disease	0.64	disease	0.39	neutral	0.52	disease	0	0.87	neutral	0.56	deleterious	-6	neutral	0.22	neutral	1.15	medium_impact	-0.22	medium_impact	0.09	medium_impact	0.54	0.8	20.07	17.52	0.35	N	0.59	polymorphism	1	0.11	.	.	.	.	.	.	COSM1155527	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12714	12714	T	G	MI.20049	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	378	126	I	M	atT/atG	3.63	0.36	0.01	benign	0.05	neutral	0.14	neutral	3.73	neutral	-0.95	deleterious	-2.67	neutral_impact	0.74	0.83	neutral	0.78	neutral	2.91	21.90	deleterious	0.58	0.65	0.66	disease	0.56	disease	0.32	neutral	0.49	neutral	0	0.85	neutral	0.55	deleterious	-6	neutral	0.59	deleterious	0.47	medium_impact	-0.2	medium_impact	-0.53	medium_impact	0.74	0.85	20.07	17.52	0.36	N	0.64	polymorphism	1	0.10	rs386829163	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5964	5964	T	G	MI.2005	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	61	21	L	V	Tta/Gta	-3.81	0	0.03	benign	0.09	neutral	0.54	neutral	2.8	neutral	1.18	neutral	-0.03	neutral_impact	0.24	0.71	neutral	0.53	neutral	1.95	15.89	deleterious	0.3	0.55	0.16	neutral	0.47	neutral	0.28	neutral	0.46	neutral	1	0.38	neutral	0.73	deleterious	-6	neutral	0.20	neutral	0.19	medium_impact	0.23	medium_impact	-0.88	medium_impact	0.73	0.9	11.31	24.94	0.31	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12714	12714	T	A	MI.20050	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	378	126	I	M	atT/atA	3.63	0.36	0.01	benign	0.05	neutral	0.14	neutral	3.73	neutral	-0.95	deleterious	-2.67	neutral_impact	0.74	0.83	neutral	0.78	neutral	3.20	22.70	deleterious	0.58	0.65	0.66	disease	0.56	disease	0.32	neutral	0.49	neutral	0	0.85	neutral	0.55	deleterious	-6	neutral	0.59	deleterious	0.47	medium_impact	-0.2	medium_impact	-0.53	medium_impact	0.74	0.85	20.07	17.52	0.35	N	0.64	polymorphism	1	0.10	rs386829163	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12715	12715	A	G	MI.20051	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	379	127	T	A	Acc/Gcc	-6.47	0	0	benign	0.1	neutral	0.46	neutral	3.93	neutral	1.4	deleterious	-4.72	neutral_impact	-1.06	0.69	neutral	0.64	neutral	1.17	11.60	neutral	0.73	0.75	0.39	neutral	0.09	neutral	0.3	neutral	0.23	neutral	5	0.47	neutral	0.68	deleterious	-6	neutral	0.65	deleterious	0.16	medium_impact	0.19	medium_impact	-2.17	low_impact	0.40	0.8	5.47	8.26	0.28	N	0.42	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12715	12715	A	T	MI.20052	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	379	127	T	S	Acc/Tcc	-6.47	0	0	possibly_damaging	0.69	neutral	0.44	neutral	4.03	neutral	1.58	deleterious	-3.78	neutral_impact	-0.36	0.71	neutral	0.67	neutral	3.09	22.50	deleterious	0.54	0.6	0.39	neutral	0.54	disease	0.39	neutral	0.47	neutral	1	0.69	neutral	0.38	neutral	-3	neutral	0.70	deleterious	-1.08	low_impact	0.18	medium_impact	-1.53	low_impact	0.62	0.8	5.47	8.26	0.31	N	0.57	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12715	12715	A	C	MI.20053	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	379	127	T	P	Acc/Ccc	-6.47	0	0	probably_damaging	0.96	neutral	0.15	neutral	3.7	deleterious	-3.56	deleterious	-5.72	medium_impact	3.08	0.62	neutral	0.32	neutral	3.33	22.90	deleterious	0.19	0.45	0.89	disease	0.92	disease	0.73	disease	0.84	disease	7	0.98	neutral	0.1	neutral	1	deleterious	0.88	deleterious	-2.06	low_impact	-0.18	medium_impact	1.61	medium_impact	0.54	0.8	5.47	8.26	0.25	N	0.94	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12716	12716	C	G	MI.20054	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	380	127	T	S	aCc/aGc	2.25	0.97	0	possibly_damaging	0.69	neutral	0.44	neutral	4.03	neutral	1.58	deleterious	-3.78	neutral_impact	-0.36	0.71	neutral	0.67	neutral	3.29	22.80	deleterious	0.54	0.6	0.39	neutral	0.54	disease	0.39	neutral	0.47	neutral	1	0.69	neutral	0.38	neutral	-3	neutral	0.70	deleterious	-1.08	low_impact	0.18	medium_impact	-1.53	low_impact	0.62	0.8	5.47	8.26	0.35	N	0.57	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12716	12716	C	A	MI.20055	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	380	127	T	N	aCc/aAc	2.25	0.97	0	probably_damaging	0.94	neutral	0.23	neutral	3.7	neutral	-2.26	deleterious	-4.78	low_impact	1.7	0.65	neutral	0.46	neutral	3.47	23.00	deleterious	0.52	0.6	0.83	disease	0.8	disease	0.63	disease	0.69	disease	4	0.96	neutral	0.15	neutral	-2	neutral	0.81	deleterious	-1.88	low_impact	-0.06	medium_impact	0.35	medium_impact	0.75	0.85	5.47	8.26	0.36	N	0.85	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12716	12716	C	T	MI.20056	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	380	127	T	I	aCc/aTc	2.25	0.97	0	possibly_damaging	0.9	neutral	0.49	neutral	3.73	neutral	-1.29	deleterious	-5.62	medium_impact	3.08	0.68	neutral	0.55	neutral	3.83	23.40	deleterious	0.52	0.6	0.5	neutral	0.83	disease	0.61	disease	0.75	disease	5	0.89	neutral	0.3	neutral	0	NA	0.75	deleterious	-1.65	low_impact	0.22	medium_impact	1.61	medium_impact	0.57	0.8	5.47	8.26	0.42	N	0.76	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12718	12718	A	T	MI.20057	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	382	128	M	L	Ata/Tta	-20	0	0	probably_damaging	0.94	neutral	1	neutral	3.15	neutral	-2.75	deleterious	-2.96	high_impact	4.65	0.43	damaging	0.04	damaging	3.20	22.70	deleterious	0.36	0.5	0.69	disease	0.88	disease	0.69	disease	0.73	disease	5	0.94	neutral	0.53	deleterious	2	deleterious	0.63	deleterious	-1.88	low_impact	1.89	high_impact	3.04	high_impact	0.35	0.8	27.36	7.25	0.45	N	0.97	polymorphism	0.99	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12718	12718	A	G	MI.20058	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	382	128	M	V	Ata/Gta	-20	0	0	probably_damaging	0.97	neutral	0.62	neutral	3.11	neutral	-2.97	deleterious	-3.95	high_impact	4.65	0.4	damaging	0.05	damaging	2.51	19.53	deleterious	0.46	0.55	0.61	disease	0.84	disease	0.76	disease	0.78	disease	6	0.97	neutral	0.33	neutral	2	deleterious	0.68	deleterious	-2.18	low_impact	0.35	medium_impact	3.04	high_impact	0.33	0.8	27.36	7.25	0.43	N	0.94	polymorphism	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12718	12718	A	C	MI.20059	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	382	128	M	L	Ata/Cta	-20	0	0	probably_damaging	0.94	neutral	1	neutral	3.15	neutral	-2.75	deleterious	-2.96	high_impact	4.65	0.43	damaging	0.04	damaging	3.02	22.30	deleterious	0.36	0.5	0.69	disease	0.88	disease	0.69	disease	0.73	disease	5	0.94	neutral	0.53	deleterious	2	deleterious	0.63	deleterious	-1.88	low_impact	1.89	high_impact	3.04	high_impact	0.35	0.8	27.36	7.25	0.44	N	0.97	polymorphism	0.99	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5964	5964	T	A	MI.2006	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	61	21	L	M	Tta/Ata	-3.81	0	0.03	benign	0.09	neutral	0.23	neutral	2.56	neutral	-1.79	neutral	-0.36	neutral_impact	0.49	0.75	neutral	0.89	neutral	2.20	17.48	deleterious	0.22	0.55	0.34	neutral	0.44	neutral	0.27	neutral	0.47	neutral	1	0.74	neutral	0.57	deleterious	-6	neutral	0.21	neutral	0.19	medium_impact	-0.1	medium_impact	-0.65	medium_impact	0.63	0.9	11.31	24.94	0.48	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12719	12719	T	A	MI.20060	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	383	128	M	K	aTa/aAa	5.46	1	0	probably_damaging	0.98	neutral	0.2	neutral	3	deleterious	-6.47	deleterious	-5.92	high_impact	5	0.46	damaging	0.04	damaging	3.79	23.40	deleterious	0.21	0.45	0.94	disease	0.93	disease	0.81	disease	0.86	disease	7	0.99	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	-0.1	medium_impact	3.36	high_impact	0.26	0.8	27.36	7.25	0.66	P	1.00	disease_causing	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12719	12719	T	C	MI.20061	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	383	128	M	T	aTa/aCa	5.46	1	0	probably_damaging	0.98	neutral	0.36	neutral	3.05	deleterious	-4.44	deleterious	-5.92	high_impact	4.11	0.43	damaging	0.06	damaging	2.80	21.40	deleterious	0.48	0.55	0.83	disease	0.86	disease	0.75	disease	0.79	disease	6	0.98	deleterious	0.19	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	0.1	medium_impact	2.55	high_impact	0.26	0.8	27.36	7.25	0.56	P	0.99	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12720	12720	A	T	MI.20062	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	384	128	M	I	atA/atT	5.69	1	0.01	probably_damaging	0.97	neutral	0.66	neutral	3.09	deleterious	-3.6	deleterious	-3.95	high_impact	4.11	0.44	damaging	0.05	damaging	3.23	22.80	deleterious	0.42	0.5	0.74	disease	0.86	disease	0.75	disease	0.77	disease	5	0.97	neutral	0.35	neutral	2	deleterious	0.78	deleterious	-2.18	low_impact	0.39	medium_impact	2.55	high_impact	0.43	0.8	27.36	7.25	0.67	P	0.96	disease_causing	1	0.27	rs2853500	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12720	12720	A	C	MI.20063	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	384	128	M	I	atA/atC	5.69	1	0.01	probably_damaging	0.97	neutral	0.66	neutral	3.09	deleterious	-3.6	deleterious	-3.95	high_impact	4.11	0.44	damaging	0.05	damaging	3.17	22.70	deleterious	0.42	0.5	0.74	disease	0.86	disease	0.75	disease	0.77	disease	5	0.97	neutral	0.35	neutral	2	deleterious	0.78	deleterious	-2.18	low_impact	0.39	medium_impact	2.55	high_impact	0.43	0.8	27.36	7.25	0.66	P	0.96	disease_causing	1	0.27	rs2853500	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12721	12721	C	G	MI.20064	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	385	129	L	V	Cta/Gta	0.64	0.05	0	benign	0.35	neutral	0.86	neutral	3.34	neutral	-2.43	neutral	-1.12	medium_impact	2.68	0.74	neutral	0.84	neutral	0.31	5.81	deleterious	0.56	0.6	0.68	disease	0.47	neutral	0.31	neutral	0.62	disease	2	0.24	neutral	0.76	deleterious	-3	neutral	0.35	neutral	-0.49	medium_impact	0.67	medium_impact	1.25	medium_impact	0.73	0.85	20.73	14.68	0.32	N	0.43	polymorphism	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12721	12721	C	A	MI.20065	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	385	129	L	M	Cta/Ata	0.64	0.05	0	probably_damaging	0.92	neutral	0.59	neutral	3.35	neutral	-2.18	neutral	0.74	low_impact	0.94	0.8	neutral	0.96	neutral	1.76	14.75	neutral	0.41	0.5	0.54	disease	0.16	neutral	0.21	neutral	0.32	neutral	4	0.9	neutral	0.34	neutral	-2	neutral	0.62	deleterious	-1.75	low_impact	0.32	medium_impact	-0.34	medium_impact	0.64	0.8	20.73	14.68	0.33	N	0.01	polymorphism	0.98	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12722	12722	T	G	MI.20066	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	386	129	L	R	cTa/cGa	-1.42	0	0	probably_damaging	0.97	neutral	0.3	neutral	3.22	deleterious	-5.92	deleterious	-4.15	high_impact	4.42	0.62	neutral	0.47	neutral	3.96	23.60	deleterious	0.16	0.45	0.94	disease	0.91	disease	0.72	disease	0.84	disease	7	0.97	neutral	0.17	neutral	2	deleterious	0.88	deleterious	-2.18	low_impact	0.03	medium_impact	2.83	high_impact	0.57	0.8	20.73	14.68	0.49	N	0.83	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12722	12722	T	C	MI.20067	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	386	129	L	P	cTa/cCa	-1.42	0	0	probably_damaging	0.97	neutral	0.14	neutral	3.23	deleterious	-6.24	deleterious	-4.92	medium_impact	3.32	0.68	neutral	0.39	neutral	3.75	23.30	deleterious	0.19	0.45	0.95	disease	0.89	disease	0.72	disease	0.85	disease	7	0.98	deleterious	0.09	neutral	1	deleterious	0.88	deleterious	-2.18	low_impact	-0.2	medium_impact	1.83	medium_impact	0.70	0.85	20.73	14.68	0.29	N	0.91	disease_causing	0.63	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12722	12722	T	A	MI.20068	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	386	129	L	Q	cTa/cAa	-1.42	0	0	probably_damaging	0.97	neutral	0.34	neutral	3.23	deleterious	-4.77	deleterious	-3.65	high_impact	4.07	0.68	neutral	0.56	neutral	3.98	23.60	deleterious	0.2	0.45	0.94	disease	0.73	disease	0.6	disease	0.83	disease	7	0.97	neutral	0.19	neutral	2	deleterious	0.81	deleterious	-2.18	low_impact	0.07	medium_impact	2.52	high_impact	0.75	0.85	20.73	14.68	0.4	N	0.83	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12724	12724	A	C	MI.20069	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	388	130	I	L	Atc/Ctc	-1.42	0	0	benign	0.4	neutral	0.92	neutral	3.85	neutral	0.96	neutral	-1.89	low_impact	0.94	0.74	neutral	0.26	damaging	3.55	23.10	deleterious	0.33	0.5	0.42	neutral	0.67	disease	0.31	neutral	0.48	neutral	0	0.32	neutral	0.76	deleterious	-6	neutral	0.61	deleterious	-0.58	medium_impact	0.82	medium_impact	-0.34	medium_impact	0.38	0.8	2.99	7.61	0.22	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5965	5965	T	C	MI.2007	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	62	21	L	S	tTa/tCa	-1.96	0	0	possibly_damaging	0.76	deleterious	0	neutral	2.58	neutral	-1.82	neutral	-1.86	medium_impact	2.55	0.56	damaging	0.15	damaging	3.66	23.20	deleterious	0.22	0.55	0.45	neutral	0.72	disease	0.51	disease	0.59	disease	2	1	deleterious	0.12	neutral	4	deleterious	0.72	deleterious	-1.23	low_impact	-1.48	low_impact	1.26	medium_impact	0.73	0.9	11.31	24.94	0.33	N	0.73	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12724	12724	A	T	MI.20070	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	388	130	I	F	Atc/Ttc	-1.42	0	0	probably_damaging	0.94	neutral	0.71	neutral	3.67	neutral	-1.32	deleterious	-3.79	medium_impact	2.02	0.8	neutral	0.12	damaging	3.65	23.20	deleterious	0.37	0.5	0.61	disease	0.81	disease	0.48	neutral	0.62	disease	2	0.93	neutral	0.39	neutral	1	deleterious	0.76	deleterious	-1.88	low_impact	0.45	medium_impact	0.64	medium_impact	0.51	0.8	2.99	7.61	0.16	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12724	12724	A	G	MI.20071	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	388	130	I	V	Atc/Gtc	-1.42	0	0	benign	0.4	neutral	0.53	neutral	3.73	neutral	0.11	neutral	-0.84	low_impact	1.9	0.79	neutral	0.95	neutral	1.72	14.50	neutral	0.56	0.6	0.51	disease	0.28	neutral	0.33	neutral	0.35	neutral	3	0.42	neutral	0.57	deleterious	-6	neutral	0.59	deleterious	-0.58	medium_impact	0.26	medium_impact	0.53	medium_impact	0.34	0.8	2.99	7.61	0.33	N	0.08	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12725	12725	T	G	MI.20072	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	389	130	I	S	aTc/aGc	3.17	0.07	0	possibly_damaging	0.65	neutral	0.57	neutral	3.62	neutral	-1.84	deleterious	-5.58	medium_impact	3.17	0.7	neutral	0.1	damaging	4.11	23.80	deleterious	0.34	0.5	0.51	disease	0.84	disease	0.56	disease	0.69	disease	4	0.6	neutral	0.46	neutral	0	NA	0.74	deleterious	-1	low_impact	0.3	medium_impact	1.69	medium_impact	0.42	0.8	2.99	7.61	0.26	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12725	12725	T	C	MI.20073	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	389	130	I	T	aTc/aCc	3.17	0.07	0	benign	0.08	neutral	0.47	neutral	3.64	neutral	-1.31	deleterious	-4.46	low_impact	0.99	0.78	neutral	0.35	neutral	2.22	17.64	deleterious	0.49	0.55	0.7	disease	0.41	neutral	0.35	neutral	0.63	disease	3	0.47	neutral	0.7	deleterious	-6	neutral	0.73	deleterious	0.26	medium_impact	0.2	medium_impact	-0.3	medium_impact	0.50	0.8	2.99	7.61	0.32	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12725	12725	T	A	MI.20074	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	389	130	I	N	aTc/aAc	3.17	0.07	0	possibly_damaging	0.89	neutral	0.44	neutral	3.59	neutral	-2.87	deleterious	-6.57	medium_impact	3.09	0.69	neutral	0.11	damaging	4.51	24.30	deleterious	0.29	0.45	0.82	disease	0.84	disease	0.58	disease	0.72	disease	4	0.88	neutral	0.28	neutral	0	NA	0.81	deleterious	-1.61	low_impact	0.18	medium_impact	1.62	medium_impact	0.51	0.8	2.99	7.61	0.33	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12726	12726	C	A	MI.20075	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	390	130	I	M	atC/atA	0.64	0.04	0	probably_damaging	0.94	neutral	0.47	neutral	3.69	neutral	-0.48	deleterious	-2.8	medium_impact	1.99	0.72	neutral	0.23	damaging	3.68	23.30	deleterious	0.39	0.5	0.68	disease	0.53	disease	0.44	neutral	0.51	disease	0	0.94	neutral	0.27	neutral	1	deleterious	0.72	deleterious	-1.88	low_impact	0.2	medium_impact	0.62	medium_impact	0.56	0.8	2.99	7.61	0.28	N	0.58	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12726	12726	C	G	MI.20076	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	390	130	I	M	atC/atG	0.64	0.04	0	probably_damaging	0.94	neutral	0.47	neutral	3.69	neutral	-0.48	deleterious	-2.8	medium_impact	1.99	0.72	neutral	0.23	damaging	3.27	22.80	deleterious	0.39	0.5	0.68	disease	0.53	disease	0.44	neutral	0.51	disease	0	0.94	neutral	0.27	neutral	1	deleterious	0.72	deleterious	-1.88	low_impact	0.2	medium_impact	0.62	medium_impact	0.56	0.8	2.99	7.61	0.28	N	0.58	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12727	12727	T	G	MI.20077	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	391	131	L	V	Tta/Gta	-8.3	0	0	probably_damaging	1	neutral	0.7	neutral	3.49	neutral	-0.54	deleterious	-2.96	medium_impact	3.04	0.41	damaging	0.04	damaging	3.30	22.90	deleterious	0.48	0.55	0.67	disease	0.65	disease	0.65	disease	0.66	disease	3	1	deleterious	0.35	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.44	medium_impact	1.57	medium_impact	0.68	0.85	30.35	7.18	0.38	N	0.78	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12727	12727	T	A	MI.20078	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	391	131	L	M	Tta/Ata	-8.3	0	0	probably_damaging	1	neutral	0.32	neutral	3.32	neutral	-2.21	neutral	-1.97	medium_impact	3.41	0.39	damaging	0.11	damaging	3.46	23.00	deleterious	0.4	0.5	0.77	disease	0.65	disease	0.64	disease	0.68	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.05	medium_impact	1.91	medium_impact	0.74	0.85	30.35	7.18	0.45	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12728	12728	T	G	MI.20079	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	392	131	L	W	tTa/tGa	-1.88	0	0	probably_damaging	1	neutral	0.15	neutral	3.2	deleterious	-6.88	deleterious	-5.92	high_impact	4.88	0.44	damaging	0.02	damaging	3.63	23.20	deleterious	0.13	0.4	0.98	disease	0.8	disease	0.69	disease	0.83	disease	7	1	deleterious	0.08	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.18	medium_impact	3.26	high_impact	0.53	0.8	30.35	7.18	0.5	P	0.98	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5965	5965	T	G	MI.2008	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	62	21	L	W	tTa/tGa	-1.96	0	0	probably_damaging	0.96	deleterious	0	neutral	2.53	deleterious	-4.62	neutral	-2.16	medium_impact	2.55	0.59	damaging	0.11	damaging	3.56	23.10	deleterious	0.1	0.55	0.55	disease	0.85	disease	0.52	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-2.06	low_impact	-1.48	low_impact	1.26	medium_impact	0.52	0.9	11.31	24.94	0.24	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12728	12728	T	C	MI.20080	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	392	131	L	S	tTa/tCa	-1.88	0	0	probably_damaging	1	neutral	0.91	neutral	3.24	deleterious	-3.65	deleterious	-5.92	high_impact	4.08	0.44	damaging	0.04	damaging	3.63	23.20	deleterious	0.23	0.45	0.81	disease	0.78	disease	0.67	disease	0.73	disease	5	1	deleterious	0.46	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.79	medium_impact	2.52	high_impact	0.74	0.85	30.35	7.18	0.31	N	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12729	12729	A	C	MI.20081	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	393	131	L	F	ttA/ttC	5.69	0.87	0	probably_damaging	1	neutral	0.67	neutral	3.26	deleterious	-3.1	deleterious	-3.95	medium_impact	3.25	0.4	damaging	0.05	damaging	3.33	22.90	deleterious	0.47	0.55	0.87	disease	0.74	disease	0.58	disease	0.7	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.4	medium_impact	1.77	medium_impact	0.77	0.85	30.35	7.18	0.57	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12729	12729	A	T	MI.20082	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	393	131	L	F	ttA/ttT	5.69	0.87	0	probably_damaging	1	neutral	0.67	neutral	3.26	deleterious	-3.1	deleterious	-3.95	medium_impact	3.25	0.4	damaging	0.05	damaging	3.46	23.00	deleterious	0.47	0.55	0.87	disease	0.74	disease	0.58	disease	0.7	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.4	medium_impact	1.77	medium_impact	0.77	0.85	30.35	7.18	0.58	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12730	12730	G	T	MI.20083	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	394	132	V	F	Gtt/Ttt	-2.57	0	0	possibly_damaging	0.64	neutral	0.69	neutral	3.41	neutral	-1.52	deleterious	-4.65	high_impact	4.53	0.63	neutral	0.43	neutral	3.37	22.90	deleterious	0.3	0.45	0.57	disease	0.94	disease	0.65	disease	0.78	disease	6	0.57	neutral	0.53	deleterious	1	deleterious	0.68	deleterious	-0.98	medium_impact	0.42	medium_impact	2.94	high_impact	0.71	0.85	14.1	14.48	0.39	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12730	12730	G	A	MI.20084	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	394	132	V	I	Gtt/Att	-2.57	0	0	benign	0.01	neutral	0.41	neutral	3.37	neutral	-2.58	neutral	-0.88	low_impact	1.27	0.76	neutral	0.66	neutral	0.39	6.53	deleterious	0.56	0.6	0.68	disease	0.54	disease	0.4	neutral	0.48	neutral	0	0.58	neutral	0.7	deleterious	-6	neutral	0.20	neutral	1.15	medium_impact	0.15	medium_impact	-0.04	medium_impact	0.95	0.95	14.1	14.48	0.27	N	0.38	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12730	12730	G	C	MI.20085	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	394	132	V	L	Gtt/Ctt	-2.57	0	0	benign	0.14	neutral	0.66	neutral	3.31	neutral	-2.49	deleterious	-2.73	medium_impact	2.46	0.68	neutral	0.51	neutral	1.52	13.41	neutral	0.46	0.55	0.71	disease	0.85	disease	0.55	disease	0.64	disease	3	0.22	neutral	0.76	deleterious	-3	neutral	0.31	neutral	0	medium_impact	0.39	medium_impact	1.04	medium_impact	0.70	0.85	14.1	14.48	0.23	N	0.54	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12731	12731	T	G	MI.20086	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	395	132	V	G	gTt/gGt	2.02	0.91	0	possibly_damaging	0.6	neutral	0.34	neutral	3.21	deleterious	-5.62	deleterious	-6.61	high_impact	4.53	0.66	neutral	0.6	neutral	3.48	23.10	deleterious	0.22	0.45	0.56	disease	0.88	disease	0.67	disease	0.74	disease	5	0.69	neutral	0.37	neutral	1	deleterious	0.68	deleterious	-0.91	medium_impact	0.07	medium_impact	2.94	high_impact	0.60	0.8	14.1	14.48	0.47	N	0.89	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12731	12731	T	C	MI.20087	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	395	132	V	A	gTt/gCt	2.02	0.91	0	benign	0.22	neutral	0.56	neutral	3.32	neutral	-2.32	deleterious	-3.71	medium_impact	2.87	0.69	neutral	0.63	neutral	1.75	14.67	neutral	0.47	0.55	0.68	disease	0.69	disease	0.63	disease	0.61	disease	2	0.33	neutral	0.67	deleterious	-3	neutral	0.49	deleterious	-0.22	medium_impact	0.29	medium_impact	1.42	medium_impact	0.55	0.8	14.1	14.48	0.29	N	0.67	polymorphism	1	0.19	.	.	.	.	.	.	COSM218996	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12731	12731	T	A	MI.20088	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	395	132	V	D	gTt/gAt	2.02	0.91	0	possibly_damaging	0.77	neutral	0.24	neutral	3.19	deleterious	-7.25	deleterious	-6.5	high_impact	4.53	0.63	neutral	0.42	neutral	4.33	24.00	deleterious	0.11	0.4	0.96	disease	0.92	disease	0.76	disease	0.86	disease	7	0.85	neutral	0.24	neutral	1	deleterious	0.81	deleterious	-1.24	low_impact	-0.04	medium_impact	2.94	high_impact	0.68	0.85	14.1	14.48	0.5	N	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12733	12733	A	C	MI.20089	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	397	133	T	P	Acc/Ccc	-11.51	0	0	probably_damaging	0.96	neutral	0.2	neutral	3.53	deleterious	-4.37	deleterious	-5.28	high_impact	3.66	0.64	neutral	0.13	damaging	3.35	22.90	deleterious	0.22	0.45	0.87	disease	0.9	disease	0.77	disease	0.86	disease	7	0.97	neutral	0.12	neutral	2	deleterious	0.84	deleterious	-2.06	low_impact	-0.1	medium_impact	2.14	high_impact	0.64	0.8	14.76	14.74	0.35	N	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5966	5966	A	T	MI.2009	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	63	21	L	F	ttA/ttT	7.53	0.98	0	benign	0.42	neutral	0.07	neutral	2.57	neutral	-2.02	neutral	-1.07	low_impact	1.66	0.6	neutral	0.12	damaging	3.36	22.90	deleterious	0.29	0.55	0.37	neutral	0.74	disease	0.41	neutral	0.56	disease	1	0.92	neutral	0.33	neutral	-6	neutral	0.62	deleterious	-0.62	medium_impact	-0.43	medium_impact	0.43	medium_impact	0.66	0.9	11.31	24.94	0.5	N	0.87	polymorphism	0.55	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12733	12733	A	G	MI.20090	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	397	133	T	A	Acc/Gcc	-11.51	0	0	possibly_damaging	0.58	neutral	0.5	neutral	3.62	neutral	-0.42	deleterious	-4.13	medium_impact	2.38	0.71	neutral	0.26	damaging	3.37	22.90	deleterious	0.74	0.8	0.52	disease	0.65	disease	0.63	disease	0.61	disease	2	0.56	neutral	0.46	neutral	0	NA	0.73	deleterious	-0.88	medium_impact	0.23	medium_impact	0.97	medium_impact	0.56	0.8	14.76	14.74	0.25	N	0.71	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12733	12733	A	T	MI.20091	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	397	133	T	S	Acc/Tcc	-11.51	0	0	benign	0.25	neutral	0.41	neutral	3.7	neutral	-0.11	deleterious	-2.82	neutral_impact	0.58	0.76	neutral	0.89	neutral	1.72	14.52	neutral	0.67	0.7	0.51	disease	0.43	neutral	0.39	neutral	0.32	neutral	4	0.5	neutral	0.58	deleterious	-6	neutral	0.71	deleterious	-0.29	medium_impact	0.15	medium_impact	-0.67	medium_impact	0.81	0.85	14.76	14.74	0.34	N	0.17	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12734	12734	C	A	MI.20092	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	398	133	T	N	aCc/aAc	1.33	0.05	0	possibly_damaging	0.84	neutral	0.32	neutral	3.53	deleterious	-4.2	deleterious	-4.13	medium_impact	3.31	0.72	neutral	0.11	damaging	3.49	23.10	deleterious	0.53	0.6	0.9	disease	0.84	disease	0.66	disease	0.78	disease	6	0.86	neutral	0.24	neutral	0	NA	0.80	deleterious	-1.43	low_impact	0.05	medium_impact	1.82	medium_impact	0.78	0.85	14.76	14.74	0.3	N	0.63	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12734	12734	C	G	MI.20093	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	398	133	T	S	aCc/aGc	1.33	0.05	0	benign	0.25	neutral	0.41	neutral	3.7	neutral	-0.11	deleterious	-2.82	neutral_impact	0.58	0.76	neutral	0.89	neutral	1.92	15.69	deleterious	0.67	0.7	0.51	disease	0.43	neutral	0.39	neutral	0.32	neutral	4	0.5	neutral	0.58	deleterious	-6	neutral	0.71	deleterious	-0.29	medium_impact	0.15	medium_impact	-0.67	medium_impact	0.81	0.85	14.76	14.74	0.35	N	0.17	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12734	12734	C	T	MI.20094	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	398	133	T	I	aCc/aTc	1.33	0.05	0	probably_damaging	0.96	neutral	0.4	neutral	3.64	neutral	-0.73	deleterious	-5.44	low_impact	1.5	0.76	neutral	0.28	damaging	3.84	23.40	deleterious	0.61	0.65	0.57	disease	0.83	disease	0.58	disease	0.56	disease	1	0.96	neutral	0.22	neutral	-2	neutral	0.76	deleterious	-2.06	low_impact	0.14	medium_impact	0.17	medium_impact	0.65	0.8	14.76	14.74	0.25	N	0.91	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12736	12736	G	A	MI.20095	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	400	134	A	T	Gct/Act	-11.28	0	0	probably_damaging	0.94	neutral	0.67	neutral	4.26	deleterious	-3.42	deleterious	-3.66	medium_impact	2.32	0.67	neutral	0.52	neutral	4.09	23.70	deleterious	0.61	0.65	0.73	disease	0.82	disease	0.67	disease	0.59	disease	2	0.93	neutral	0.37	neutral	1	deleterious	0.83	deleterious	-1.88	low_impact	0.4	medium_impact	0.92	medium_impact	0.75	0.85	8.13	7.47	0.23	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	COSM488733	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12736	12736	G	T	MI.20096	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	400	134	A	S	Gct/Tct	-11.28	0	0	possibly_damaging	0.57	neutral	0.65	neutral	5.06	neutral	1.2	deleterious	-2.53	neutral_impact	0.28	0.66	neutral	0.65	neutral	3.53	23.10	deleterious	0.55	0.6	0.48	neutral	0.67	disease	0.49	neutral	0.46	neutral	1	0.5	neutral	0.54	deleterious	-3	neutral	0.77	deleterious	-0.86	medium_impact	0.38	medium_impact	-0.95	medium_impact	0.91	0.95	8.13	7.47	0.29	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12736	12736	G	C	MI.20097	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	400	134	A	P	Gct/Cct	-11.28	0	0	probably_damaging	0.99	neutral	0.24	neutral	4.26	deleterious	-3.46	deleterious	-4.72	high_impact	4.46	0.67	neutral	0.33	neutral	3.74	23.30	deleterious	0.24	0.45	0.96	disease	0.93	disease	0.79	disease	0.85	disease	7	0.99	deleterious	0.13	neutral	2	deleterious	0.90	deleterious	-2.64	low_impact	-0.04	medium_impact	2.87	high_impact	0.73	0.85	8.13	7.47	0.54	N	0.96	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12737	12737	C	A	MI.20098	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	401	134	A	D	gCt/gAt	5.92	1	0	probably_damaging	0.98	neutral	0.33	neutral	4.23	deleterious	-5.35	deleterious	-5.56	high_impact	4.46	0.68	neutral	0.38	neutral	4.32	24.00	deleterious	0.19	0.45	0.97	disease	0.93	disease	0.77	disease	0.84	disease	7	0.98	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-2.35	low_impact	0.06	medium_impact	2.87	high_impact	0.70	0.85	8.13	7.47	0.63	P	0.95	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12737	12737	C	T	MI.20099	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	401	134	A	V	gCt/gTt	5.92	1	0	probably_damaging	0.97	neutral	0.55	neutral	4.3	neutral	-2.53	deleterious	-3.87	medium_impact	3.02	0.66	neutral	0.36	neutral	4.27	24.00	deleterious	0.49	0.55	0.75	disease	0.88	disease	0.62	disease	0.7	disease	4	0.96	neutral	0.29	neutral	1	deleterious	0.84	deleterious	-2.18	low_impact	0.28	medium_impact	1.56	medium_impact	0.71	0.85	8.13	7.47	0.5	P	0.76	disease_causing	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8620	8620	C	G	MI.201	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	94	32	P	A	Ccc/Gcc	-6.35	0	0	probably_damaging	1	neutral	0.08	neutral	4.5	neutral	2.37	deleterious	-6.2	medium_impact	2.42	0.86	neutral	0.19	damaging	2.93	22.00	deleterious	0.45	0.65	0.58	disease	0.56	disease	0.5	neutral	0.46	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	-0.31	medium_impact	0.98	medium_impact	0.65	0.9	29.2	19.38	0.32	N	0.73	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5966	5966	A	C	MI.2010	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	63	21	L	F	ttA/ttC	7.53	0.98	0	benign	0.42	neutral	0.07	neutral	2.57	neutral	-2.02	neutral	-1.07	low_impact	1.66	0.6	neutral	0.12	damaging	3.32	22.90	deleterious	0.29	0.55	0.37	neutral	0.74	disease	0.41	neutral	0.56	disease	1	0.92	neutral	0.33	neutral	-6	neutral	0.62	deleterious	-0.62	medium_impact	-0.43	medium_impact	0.43	medium_impact	0.66	0.9	11.31	24.94	0.5	N	0.87	polymorphism	0.55	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12737	12737	C	G	MI.20100	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	401	134	A	G	gCt/gGt	5.92	1	0	possibly_damaging	0.9	neutral	0.39	neutral	4.25	deleterious	-3.84	deleterious	-3.73	medium_impact	2.4	0.66	neutral	0.5	neutral	3.85	23.40	deleterious	0.38	0.5	0.88	disease	0.82	disease	0.68	disease	0.75	disease	5	0.9	neutral	0.25	neutral	0	NA	0.81	deleterious	-1.65	low_impact	0.13	medium_impact	0.99	medium_impact	0.86	0.9	8.13	7.47	0.57	P	0.82	disease_causing	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12739	12739	A	C	MI.20101	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	403	135	N	H	Aac/Cac	-7.38	0	0	probably_damaging	1	neutral	0.54	neutral	4.49	deleterious	-3.41	deleterious	-4.93	medium_impact	3.29	0.64	neutral	0.12	damaging	2.93	22.00	deleterious	0.64	0.7	0.78	disease	0.9	disease	0.71	disease	0.77	disease	5	1	deleterious	0.27	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.27	medium_impact	1.8	medium_impact	0.49	0.8	18.57	7.13	0.23	N	0.97	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12739	12739	A	T	MI.20102	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	403	135	N	Y	Aac/Tac	-7.38	0	0	probably_damaging	1	neutral	1	neutral	4.52	deleterious	-3.66	deleterious	-7.89	medium_impact	3.29	0.69	neutral	0.09	damaging	3.63	23.20	deleterious	0.47	0.55	0.84	disease	0.94	disease	0.7	disease	0.81	disease	6	1	deleterious	0.5	deleterious	1	deleterious	0.86	deleterious	-3.6	low_impact	1.89	high_impact	1.8	medium_impact	0.40	0.8	18.57	7.13	0.24	N	0.99	polymorphism	0.95	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12739	12739	A	G	MI.20103	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	403	135	N	D	Aac/Gac	-7.38	0	0	probably_damaging	1	neutral	0.21	neutral	4.57	neutral	0.34	deleterious	-4.93	low_impact	0.82	0.66	neutral	0.18	damaging	3.73	23.30	deleterious	0.76	0.8	0.46	neutral	0.72	disease	0.64	disease	0.54	disease	1	1	deleterious	0.11	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	-0.09	medium_impact	-0.45	medium_impact	0.57	0.8	18.57	7.13	0.27	N	0.94	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12740	12740	A	C	MI.20104	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	404	135	N	T	aAc/aCc	8.44	1	0	probably_damaging	1	neutral	0.4	neutral	4.52	neutral	-1.19	deleterious	-5.92	medium_impact	2.9	0.69	neutral	0.09	damaging	3.27	22.80	deleterious	0.64	0.7	0.69	disease	0.88	disease	0.66	disease	0.73	disease	5	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.14	medium_impact	1.45	medium_impact	0.49	0.8	18.57	7.13	0.45	N	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12740	12740	A	G	MI.20105	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	404	135	N	S	aAc/aGc	8.44	1	0	probably_damaging	1	neutral	0.41	neutral	4.64	neutral	-1.17	deleterious	-4.93	low_impact	1.85	0.7	neutral	0.16	damaging	2.97	22.10	deleterious	0.76	0.8	0.57	disease	0.85	disease	0.64	disease	0.67	disease	3	1	deleterious	0.21	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.15	medium_impact	0.49	medium_impact	0.26	0.8	18.57	7.13	0.44	N	0.82	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12740	12740	A	T	MI.20106	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	404	135	N	I	aAc/aTc	8.44	1	0	probably_damaging	1	neutral	0.4	neutral	4.47	deleterious	-3.35	deleterious	-8.88	medium_impact	2.94	0.66	neutral	0.1	damaging	3.76	23.30	deleterious	0.43	0.55	0.59	disease	0.96	disease	0.66	disease	0.8	disease	6	1	deleterious	0.2	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.14	medium_impact	1.48	medium_impact	0.23	0.8	18.57	7.13	0.42	N	0.99	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12741	12741	C	A	MI.20107	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	405	135	N	K	aaC/aaA	8.44	1	0	probably_damaging	1	neutral	0.31	neutral	4.55	neutral	-1.69	deleterious	-5.92	medium_impact	3.4	0.7	neutral	0.09	damaging	4.30	24.00	deleterious	0.68	0.7	0.66	disease	0.94	disease	0.69	disease	0.79	disease	6	1	deleterious	0.16	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.04	medium_impact	1.9	medium_impact	0.56	0.8	18.57	7.13	0.49	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12741	12741	C	G	MI.20108	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	405	135	N	K	aaC/aaG	8.44	1	0	probably_damaging	1	neutral	0.31	neutral	4.55	neutral	-1.69	deleterious	-5.92	medium_impact	3.4	0.7	neutral	0.09	damaging	3.81	23.40	deleterious	0.68	0.7	0.66	disease	0.94	disease	0.69	disease	0.79	disease	6	1	deleterious	0.16	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.04	medium_impact	1.9	medium_impact	0.56	0.8	18.57	7.13	0.49	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12742	12742	A	C	MI.20109	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	406	136	N	H	Aac/Cac	-1.65	0	0	probably_damaging	1	neutral	0.57	neutral	4.26	deleterious	-3.88	deleterious	-4.93	medium_impact	3.21	0.57	damaging	0.03	damaging	2.83	21.50	deleterious	0.42	0.55	0.85	disease	0.89	disease	0.72	disease	0.8	disease	6	1	deleterious	0.29	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.3	medium_impact	1.73	medium_impact	0.46	0.8	28.86	7.2	0.22	N	0.97	disease_causing	0.98	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5967	5967	T	A	MI.2011	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	64	22	F	I	Ttc/Atc	-0.34	0.55	0	probably_damaging	0.99	neutral	0.05	neutral	2.81	deleterious	-3.14	neutral	-2.07	medium_impact	2.98	0.7	neutral	0.16	damaging	4.13	23.80	deleterious	0.23	0.55	0.38	neutral	0.83	disease	0.57	disease	0.68	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.79	deleterious	-2.64	low_impact	-0.52	medium_impact	1.65	medium_impact	0.64	0.9	2.92	6.69	0.3	N	0.88	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12742	12742	A	T	MI.20110	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	406	136	N	Y	Aac/Tac	-1.65	0	0	probably_damaging	1	neutral	1	neutral	4.21	deleterious	-6.18	deleterious	-7.89	high_impact	4.01	0.57	damaging	0.03	damaging	3.37	22.90	deleterious	0.33	0.5	0.94	disease	0.93	disease	0.72	disease	0.82	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.6	low_impact	1.89	high_impact	2.46	high_impact	0.36	0.8	28.86	7.2	0.3	N	0.99	disease_causing	0.99	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12742	12742	A	G	MI.20111	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	406	136	N	D	Aac/Gac	-1.65	0	0	probably_damaging	1	neutral	0.44	neutral	4.59	neutral	-0.24	deleterious	-4.93	medium_impact	2.38	0.57	damaging	0.04	damaging	3.57	23.20	deleterious	0.64	0.7	0.46	neutral	0.84	disease	0.71	disease	0.75	disease	5	1	deleterious	0.22	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.18	medium_impact	0.97	medium_impact	0.75	0.85	28.86	7.2	0.21	N	0.94	disease_causing	0.95	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12743	12743	A	C	MI.20112	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	407	136	N	T	aAc/aCc	6.84	1	0	probably_damaging	1	neutral	0.62	neutral	4.23	deleterious	-4.26	deleterious	-5.92	high_impact	3.52	0.47	damaging	0.02	damaging	3.75	23.30	deleterious	0.4	0.5	0.8	disease	0.88	disease	0.69	disease	0.75	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.35	medium_impact	2.01	high_impact	0.48	0.8	28.86	7.2	0.48	N	0.94	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12743	12743	A	G	MI.20113	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	407	136	N	S	aAc/aGc	6.84	1	0	probably_damaging	1	neutral	0.71	neutral	4.34	neutral	-2.98	deleterious	-4.93	low_impact	1.49	0.48	damaging	0.07	damaging	3.51	23.10	deleterious	0.63	0.7	0.74	disease	0.82	disease	0.63	disease	0.56	disease	1	1	deleterious	0.36	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.45	medium_impact	0.16	medium_impact	0.41	0.8	28.86	7.2	0.43	N	0.82	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12743	12743	A	T	MI.20114	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	407	136	N	I	aAc/aTc	6.84	1	0	probably_damaging	1	neutral	0.47	neutral	4.21	deleterious	-6.38	deleterious	-8.88	high_impact	4.91	0.55	damaging	0.03	damaging	4.33	24.00	deleterious	0.28	0.45	0.91	disease	0.95	disease	0.68	disease	0.81	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.2	medium_impact	3.28	high_impact	0.33	0.8	28.86	7.2	0.6	P	0.99	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12744	12744	C	A	MI.20115	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	408	136	N	K	aaC/aaA	6.84	1	0	probably_damaging	1	neutral	0.66	neutral	4.26	deleterious	-3.99	deleterious	-5.92	high_impact	4.36	0.59	damaging	0.02	damaging	4.39	24.10	deleterious	0.44	0.55	0.8	disease	0.92	disease	0.75	disease	0.82	disease	6	1	deleterious	0.33	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.39	medium_impact	2.78	high_impact	0.56	0.8	28.86	7.2	0.54	P	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12744	12744	C	G	MI.20116	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	408	136	N	K	aaC/aaG	6.84	1	0	probably_damaging	1	neutral	0.66	neutral	4.26	deleterious	-3.99	deleterious	-5.92	high_impact	4.36	0.59	damaging	0.02	damaging	3.91	23.50	deleterious	0.44	0.55	0.8	disease	0.92	disease	0.75	disease	0.82	disease	6	1	deleterious	0.33	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.39	medium_impact	2.78	high_impact	0.56	0.8	28.86	7.2	0.54	P	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12745	12745	C	G	MI.20117	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	409	137	L	V	Cta/Gta	-2.57	0	0	possibly_damaging	0.9	neutral	0.59	neutral	4.15	deleterious	-3.06	neutral	-2.27	medium_impact	2.85	0.69	neutral	0.13	damaging	3.30	22.90	deleterious	0.52	0.6	0.79	disease	0.72	disease	0.59	disease	0.7	disease	4	0.88	neutral	0.35	neutral	0	NA	0.81	deleterious	-1.65	low_impact	0.32	medium_impact	1.4	medium_impact	0.80	0.85	3.98	8.46	0.17	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12745	12745	C	A	MI.20118	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	409	137	L	M	Cta/Ata	-2.57	0	0	possibly_damaging	0.76	neutral	0.25	neutral	4.03	deleterious	-3.51	neutral	-0.92	low_impact	1.35	0.76	neutral	0.92	neutral	1.62	13.97	neutral	0.39	0.5	0.77	disease	0.08	neutral	0.33	neutral	0.34	neutral	3	0.84	neutral	0.25	neutral	-3	neutral	0.71	deleterious	-1.22	low_impact	-0.03	medium_impact	0.03	medium_impact	0.80	0.85	3.98	8.46	0.45	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12746	12746	T	A	MI.20119	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	410	137	L	Q	cTa/cAa	-4.4	0	0	probably_damaging	0.99	neutral	0.31	neutral	4.01	deleterious	-6.61	deleterious	-4.9	high_impact	4.75	0.69	neutral	0.12	damaging	4.01	23.60	deleterious	0.21	0.45	0.95	disease	0.87	disease	0.67	disease	0.84	disease	7	0.99	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-2.64	low_impact	0.04	medium_impact	3.14	high_impact	0.77	0.85	3.98	8.46	0.64	P	0.84	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5967	5967	T	C	MI.2012	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	64	22	F	L	Ttc/Ctc	-0.34	0.55	0	probably_damaging	0.98	neutral	0.21	neutral	2.91	neutral	-2.6	neutral	-1.98	low_impact	1.35	0.51	damaging	0.18	damaging	2.54	19.70	deleterious	0.32	0.55	0.19	neutral	0.72	disease	0.41	neutral	0.56	disease	1	0.99	deleterious	0.12	neutral	-2	neutral	0.72	deleterious	-2.35	low_impact	-0.13	medium_impact	0.15	medium_impact	0.56	0.9	2.92	6.69	0.38	N	0.83	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12746	12746	T	C	MI.20120	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	410	137	L	P	cTa/cCa	-4.4	0	0	probably_damaging	1	neutral	0.22	neutral	4	deleterious	-6.42	deleterious	-6	high_impact	3.94	0.57	damaging	0.1	damaging	3.82	23.40	deleterious	0.25	0.45	0.94	disease	0.95	disease	0.77	disease	0.87	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	-0.07	medium_impact	2.4	high_impact	0.83	0.85	3.98	8.46	0.33	N	0.99	disease_causing	0.78	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12746	12746	T	G	MI.20121	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	410	137	L	R	cTa/cGa	-4.4	0	0	probably_damaging	0.99	neutral	0.38	neutral	4.01	deleterious	-6.42	deleterious	-5.08	high_impact	4.75	0.62	neutral	0.1	damaging	4.11	23.80	deleterious	0.19	0.45	0.95	disease	0.95	disease	0.77	disease	0.87	disease	7	0.99	deleterious	0.2	neutral	2	deleterious	0.93	deleterious	-2.64	low_impact	0.12	medium_impact	3.14	high_impact	0.62	0.8	3.98	8.46	0.66	P	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12748	12748	T	C	MI.20122	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	412	138	F	L	Ttc/Ctc	-4.63	0	0	benign	0.08	neutral	0.68	neutral	4.89	neutral	0.51	deleterious	-4.56	neutral_impact	0.23	0.8	neutral	0.88	neutral	0.92	10.18	neutral	0.45	0.55	0.49	neutral	0.79	disease	0.45	neutral	0.51	disease	0	0.22	neutral	0.8	deleterious	-6	neutral	0.20	neutral	0.26	medium_impact	0.41	medium_impact	-0.99	medium_impact	0.78	0.85	4.15	8.74	0.2	N	0.44	disease_causing	0.74	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12748	12748	T	G	MI.20123	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	412	138	F	V	Ttc/Gtc	-4.63	0	0	possibly_damaging	0.74	neutral	0.5	neutral	4.58	neutral	-0.74	deleterious	-5.74	low_impact	1.34	0.69	neutral	0.65	neutral	2.35	18.46	deleterious	0.35	0.5	0.56	disease	0.89	disease	0.63	disease	0.56	disease	1	0.72	neutral	0.38	neutral	-3	neutral	0.46	deleterious	-1.18	low_impact	0.23	medium_impact	0.02	medium_impact	0.65	0.8	4.15	8.74	0.24	N	0.91	disease_causing	0.85	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12748	12748	T	A	MI.20124	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	412	138	F	I	Ttc/Atc	-4.63	0	0	possibly_damaging	0.63	neutral	0.42	neutral	4.82	neutral	-0.46	deleterious	-4.8	neutral_impact	0.35	0.66	neutral	0.68	neutral	2.60	20.20	deleterious	0.36	0.5	0.5	neutral	0.87	disease	0.56	disease	0.53	disease	1	0.65	neutral	0.4	neutral	-3	neutral	0.43	neutral	-0.97	medium_impact	0.16	medium_impact	-0.88	medium_impact	0.57	0.8	4.15	8.74	0.23	N	0.83	disease_causing	0.72	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12749	12749	T	A	MI.20125	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	413	138	F	Y	tTc/tAc	1.33	0.94	0	possibly_damaging	0.89	neutral	1	neutral	4.48	deleterious	-3.63	deleterious	-2.66	low_impact	1.9	0.61	neutral	0.64	neutral	4.09	23.70	deleterious	0.3	0.45	0.86	disease	0.85	disease	0.59	disease	0.68	disease	4	0.89	neutral	0.56	deleterious	-3	neutral	0.70	deleterious	-1.61	low_impact	1.89	high_impact	0.53	medium_impact	0.68	0.85	4.15	8.74	0.35	N	0.69	polymorphism	0.56	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12749	12749	T	C	MI.20126	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	413	138	F	S	tTc/tCc	1.33	0.94	0	probably_damaging	0.96	neutral	0.42	neutral	4.49	deleterious	-3.56	deleterious	-6.96	high_impact	4	0.7	neutral	0.51	neutral	4.10	23.70	deleterious	0.28	0.45	0.66	disease	0.92	disease	0.63	disease	0.73	disease	5	0.96	neutral	0.23	neutral	2	deleterious	0.74	deleterious	-2.06	low_impact	0.16	medium_impact	2.45	high_impact	0.53	0.8	4.15	8.74	0.41	N	0.98	disease_causing	0.86	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12749	12749	T	G	MI.20127	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	413	138	F	C	tTc/tGc	1.33	0.94	0	probably_damaging	0.98	neutral	0.18	neutral	4.47	deleterious	-5.12	deleterious	-6.87	high_impact	3.65	0.68	neutral	0.46	neutral	4.00	23.60	deleterious	0.32	0.5	0.94	disease	0.94	disease	0.66	disease	0.83	disease	7	0.99	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	-0.13	medium_impact	2.13	high_impact	0.36	0.8	4.15	8.74	0.41	N	0.95	disease_causing	0.91	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12750	12750	C	A	MI.20128	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	414	138	F	L	ttC/ttA	5.46	0.98	0	benign	0.08	neutral	0.68	neutral	4.89	neutral	0.51	deleterious	-4.56	neutral_impact	0.23	0.8	neutral	0.88	neutral	1.56	13.65	neutral	0.45	0.55	0.49	neutral	0.79	disease	0.45	neutral	0.51	disease	0	0.22	neutral	0.8	deleterious	-6	neutral	0.20	neutral	0.26	medium_impact	0.41	medium_impact	-0.99	medium_impact	0.78	0.85	4.15	8.74	0.45	N	0.44	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12750	12750	C	G	MI.20129	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	414	138	F	L	ttC/ttG	5.46	0.98	0	benign	0.08	neutral	0.68	neutral	4.89	neutral	0.51	deleterious	-4.56	neutral_impact	0.23	0.8	neutral	0.88	neutral	1.29	12.21	neutral	0.45	0.55	0.49	neutral	0.79	disease	0.45	neutral	0.51	disease	0	0.22	neutral	0.8	deleterious	-6	neutral	0.20	neutral	0.26	medium_impact	0.41	medium_impact	-0.99	medium_impact	0.78	0.85	4.15	8.74	0.45	N	0.44	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5967	5967	T	G	MI.2013	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	64	22	F	V	Ttc/Gtc	-0.34	0.55	0	probably_damaging	1	neutral	0.06	neutral	2.9	neutral	-2.79	neutral	-2.5	medium_impact	3.35	0.63	neutral	0.14	damaging	3.83	23.40	deleterious	0.24	0.55	0.31	neutral	0.88	disease	0.62	disease	0.7	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.47	medium_impact	1.99	medium_impact	0.59	0.9	2.92	6.69	0.29	N	0.84	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12751	12751	C	A	MI.20130	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	415	139	Q	K	Caa/Aaa	-4.4	0	0	probably_damaging	1	neutral	0.29	neutral	4.59	neutral	-2.99	deleterious	-3.95	high_impact	3.8	0.64	neutral	0.35	neutral	3.88	23.50	deleterious	0.47	0.55	0.85	disease	0.95	disease	0.73	disease	0.84	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.02	medium_impact	2.27	high_impact	0.59	0.8	28.03	7.17	0.35	N	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12751	12751	C	G	MI.20131	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	415	139	Q	E	Caa/Gaa	-4.4	0	0	probably_damaging	1	neutral	0.28	neutral	4.59	neutral	-2.4	deleterious	-2.96	medium_impact	3.17	0.66	neutral	0.41	neutral	3.06	22.40	deleterious	0.48	0.55	0.87	disease	0.9	disease	0.72	disease	0.81	disease	6	1	deleterious	0.14	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.01	medium_impact	1.69	medium_impact	0.65	0.8	28.03	7.17	0.3	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12752	12752	A	G	MI.20132	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	416	139	Q	R	cAa/cGa	2.94	0.98	0	probably_damaging	1	neutral	0.35	neutral	4.58	neutral	-2.94	deleterious	-3.95	high_impact	4.14	0.64	neutral	0.36	neutral	3.43	23.00	deleterious	0.47	0.55	0.87	disease	0.94	disease	0.74	disease	0.85	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.08	medium_impact	2.58	high_impact	0.57	0.8	28.03	7.17	0.56	P	0.85	disease_causing	0.97	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12752	12752	A	T	MI.20133	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	416	139	Q	L	cAa/cTa	2.94	0.98	0	probably_damaging	1	neutral	0.68	neutral	4.86	neutral	1.71	deleterious	-6.91	neutral_impact	0.5	0.68	neutral	0.63	neutral	3.80	23.40	deleterious	0.39	0.5	0.36	neutral	0.9	disease	0.61	disease	0.54	disease	1	1	deleterious	0.34	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.41	medium_impact	-0.75	medium_impact	0.31	0.8	28.03	7.17	0.36	N	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12752	12752	A	C	MI.20134	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	416	139	Q	P	cAa/cCa	2.94	0.98	0	probably_damaging	1	neutral	0.21	neutral	4.57	deleterious	-3.77	deleterious	-5.92	medium_impact	2.79	0.61	neutral	0.37	neutral	3.30	22.90	deleterious	0.25	0.45	0.91	disease	0.95	disease	0.74	disease	0.84	disease	7	1	deleterious	0.11	neutral	1	deleterious	0.91	deleterious	-3.6	low_impact	-0.09	medium_impact	1.35	medium_impact	0.59	0.8	28.03	7.17	0.41	N	0.95	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12753	12753	A	T	MI.20135	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	417	139	Q	H	caA/caT	6.61	0.99	0	probably_damaging	1	neutral	0.53	neutral	4.57	deleterious	-3.26	deleterious	-4.93	high_impact	3.8	0.68	neutral	0.32	neutral	3.53	23.10	deleterious	0.54	0.6	0.91	disease	0.91	disease	0.74	disease	0.82	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.26	medium_impact	2.27	high_impact	0.79	0.85	28.03	7.17	0.59	P	0.94	disease_causing	0.99	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12753	12753	A	C	MI.20136	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	417	139	Q	H	caA/caC	6.61	0.99	0	probably_damaging	1	neutral	0.53	neutral	4.57	deleterious	-3.26	deleterious	-4.93	high_impact	3.8	0.68	neutral	0.32	neutral	3.39	23.00	deleterious	0.54	0.6	0.91	disease	0.91	disease	0.74	disease	0.82	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.26	medium_impact	2.27	high_impact	0.79	0.85	28.03	7.17	0.57	P	0.94	disease_causing	0.99	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12754	12754	C	G	MI.20137	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	418	140	L	V	Ctg/Gtg	-1.19	0	0	possibly_damaging	0.81	neutral	0.52	neutral	4.57	neutral	-2.87	deleterious	-2.96	medium_impact	3.01	0.66	neutral	0.62	neutral	3.32	22.90	deleterious	0.39	0.5	0.59	disease	0.8	disease	0.6	disease	0.66	disease	3	0.79	neutral	0.36	neutral	0	NA	0.79	deleterious	-1.34	low_impact	0.25	medium_impact	1.55	medium_impact	0.69	0.85	9.29	7.17	0.26	N	0.52	polymorphism	0.88	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12754	12754	C	A	MI.20138	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	418	140	L	M	Ctg/Atg	-1.19	0	0	probably_damaging	0.98	neutral	0.24	neutral	4.68	neutral	-1.61	neutral	-1.97	low_impact	1.53	0.6	neutral	0.48	neutral	3.78	23.40	deleterious	0.31	0.45	0.58	disease	0.63	disease	0.58	disease	0.5	neutral	0	0.98	deleterious	0.13	neutral	-2	neutral	0.73	deleterious	-2.35	low_impact	-0.04	medium_impact	0.2	medium_impact	0.77	0.85	9.29	7.17	0.33	N	0.56	polymorphism	0.91	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12755	12755	T	A	MI.20139	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	419	140	L	Q	cTg/cAg	0.18	0.02	0	probably_damaging	0.99	neutral	0.31	neutral	4.49	deleterious	-5.77	deleterious	-5.92	high_impact	4.72	0.58	damaging	0.35	neutral	4.25	23.90	deleterious	0.16	0.45	0.92	disease	0.9	disease	0.6	disease	0.79	disease	6	0.99	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-2.64	low_impact	0.04	medium_impact	3.11	high_impact	0.77	0.85	9.29	7.17	0.59	P	0.95	disease_causing	0.98	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5968	5968	T	C	MI.2014	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	65	22	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-2.89	deleterious	-3.11	medium_impact	3.13	0.74	neutral	0.17	damaging	4.15	23.80	deleterious	0.25	0.55	0.36	neutral	0.87	disease	0.57	disease	0.69	disease	4	1	deleterious	0	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	1.79	medium_impact	0.64	0.9	2.92	6.69	0.49	N	0.84	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12755	12755	T	C	MI.20140	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	419	140	L	P	cTg/cCg	0.18	0.02	0	probably_damaging	0.99	neutral	0.21	neutral	4.45	deleterious	-6.34	deleterious	-6.91	high_impact	4.72	0.54	damaging	0.29	neutral	3.84	23.40	deleterious	0.15	0.45	0.96	disease	0.93	disease	0.72	disease	0.83	disease	7	0.99	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-2.64	low_impact	-0.09	medium_impact	3.11	high_impact	0.63	0.8	9.29	7.17	0.54	P	0.94	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12755	12755	T	G	MI.20141	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	419	140	L	R	cTg/cGg	0.18	0.02	0	probably_damaging	0.98	neutral	0.35	neutral	4.46	deleterious	-5.78	deleterious	-5.92	high_impact	4.72	0.56	damaging	0.31	neutral	4.11	23.80	deleterious	0.14	0.4	0.94	disease	0.95	disease	0.71	disease	0.83	disease	7	0.99	deleterious	0.19	neutral	2	deleterious	0.92	deleterious	-2.35	low_impact	0.08	medium_impact	3.11	high_impact	0.50	0.8	9.29	7.17	0.58	P	0.97	disease_causing	0.98	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12757	12757	T	C	MI.20142	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	421	141	F	L	Ttc/Ctc	-6.24	0	0	benign	0.12	neutral	0.77	neutral	4.45	neutral	-2.07	deleterious	-5.66	low_impact	1	0.59	damaging	0.56	neutral	3.89	23.50	deleterious	0.34	0.5	0.63	disease	0.86	disease	0.6	disease	0.53	disease	1	0.12	neutral	0.83	deleterious	-6	neutral	0.79	deleterious	0.08	medium_impact	0.52	medium_impact	-0.29	medium_impact	0.63	0.8	22.55	7.17	0.24	N	0.48	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12757	12757	T	A	MI.20143	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	421	141	F	I	Ttc/Atc	-6.24	0	0	possibly_damaging	0.81	neutral	0.46	neutral	4.34	deleterious	-3.71	deleterious	-5.71	medium_impact	2.69	0.6	damaging	0.58	neutral	4.30	24.00	deleterious	0.22	0.45	0.74	disease	0.93	disease	0.63	disease	0.72	disease	4	0.8	neutral	0.33	neutral	0	NA	0.84	deleterious	-1.34	low_impact	0.19	medium_impact	1.25	medium_impact	0.57	0.8	22.55	7.17	0.29	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12757	12757	T	G	MI.20144	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	421	141	F	V	Ttc/Gtc	-6.24	0	0	possibly_damaging	0.81	neutral	0.58	neutral	4.39	deleterious	-3.43	deleterious	-6.7	high_impact	3.53	0.57	damaging	0.47	neutral	3.96	23.60	deleterious	0.27	0.45	0.76	disease	0.94	disease	0.68	disease	0.77	disease	5	0.78	neutral	0.39	neutral	1	deleterious	0.83	deleterious	-1.34	low_impact	0.31	medium_impact	2.02	high_impact	0.54	0.8	22.55	7.17	0.29	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12758	12758	T	C	MI.20145	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	422	141	F	S	tTc/tCc	4.54	1	0	probably_damaging	0.97	neutral	0.62	neutral	4.31	deleterious	-5.09	deleterious	-7.74	high_impact	4.68	0.63	neutral	0.55	neutral	4.17	23.80	deleterious	0.23	0.45	0.89	disease	0.93	disease	0.66	disease	0.79	disease	6	0.97	neutral	0.33	neutral	2	deleterious	0.86	deleterious	-2.18	low_impact	0.35	medium_impact	3.07	high_impact	0.47	0.8	22.55	7.17	0.61	P	0.98	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12758	12758	T	G	MI.20146	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	422	141	F	C	tTc/tGc	4.54	1	0	probably_damaging	0.99	neutral	0.19	neutral	4.32	deleterious	-6.43	deleterious	-7.71	high_impact	4.68	0.6	damaging	0.46	neutral	4.03	23.60	deleterious	0.25	0.45	0.68	disease	0.94	disease	0.7	disease	0.85	disease	7	0.99	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.64	low_impact	-0.12	medium_impact	3.07	high_impact	0.31	0.8	22.55	7.17	0.53	P	0.96	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12758	12758	T	A	MI.20147	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	422	141	F	Y	tTc/tAc	4.54	1	0	probably_damaging	0.92	neutral	1	neutral	4.74	neutral	-0.59	deleterious	-2.91	low_impact	1.93	0.61	neutral	0.47	neutral	4.18	23.80	deleterious	0.26	0.45	0.47	neutral	0.9	disease	0.62	disease	0.71	disease	4	0.92	neutral	0.54	deleterious	-2	neutral	0.79	deleterious	-1.75	low_impact	1.89	high_impact	0.56	medium_impact	0.58	0.8	22.55	7.17	0.43	N	0.71	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12759	12759	C	A	MI.20148	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	423	141	F	L	ttC/ttA	7.3	1	0	benign	0.12	neutral	0.77	neutral	4.45	neutral	-2.07	deleterious	-5.66	low_impact	1	0.59	damaging	0.56	neutral	4.56	24.40	deleterious	0.34	0.5	0.63	disease	0.86	disease	0.6	disease	0.53	disease	1	0.12	neutral	0.83	deleterious	-6	neutral	0.79	deleterious	0.08	medium_impact	0.52	medium_impact	-0.29	medium_impact	0.63	0.8	22.55	7.17	0.43	N	0.48	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12759	12759	C	G	MI.20149	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	423	141	F	L	ttC/ttG	7.3	1	0	benign	0.12	neutral	0.77	neutral	4.45	neutral	-2.07	deleterious	-5.66	low_impact	1	0.59	damaging	0.56	neutral	4.23	23.90	deleterious	0.34	0.5	0.63	disease	0.86	disease	0.6	disease	0.53	disease	1	0.12	neutral	0.83	deleterious	-6	neutral	0.79	deleterious	0.08	medium_impact	0.52	medium_impact	-0.29	medium_impact	0.63	0.8	22.55	7.17	0.43	N	0.48	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5968	5968	T	G	MI.2015	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	65	22	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-5.27	deleterious	-3.05	high_impact	4.63	0.57	damaging	0.15	damaging	3.94	23.60	deleterious	0.24	0.55	0.71	disease	0.9	disease	0.64	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.18	high_impact	0.38	0.9	2.92	6.69	0.52	P	0.91	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12760	12760	A	C	MI.20150	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	424	142	I	L	Atc/Ctc	-6.01	0	0	probably_damaging	1	neutral	1	neutral	4.69	neutral	0.01	neutral	-1.86	low_impact	1.08	0.64	neutral	0.15	damaging	3.68	23.30	deleterious	0.42	0.55	0.36	neutral	0.74	disease	0.51	disease	0.52	disease	0	1	deleterious	0.5	deleterious	-2	neutral	0.67	deleterious	-3.6	low_impact	1.89	high_impact	-0.22	medium_impact	0.66	0.8	4.31	11.73	0.21	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12760	12760	A	G	MI.20151	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	424	142	I	V	Atc/Gtc	-6.01	0	0	probably_damaging	1	neutral	0.66	neutral	4.51	neutral	0.83	neutral	-0.93	neutral_impact	0.77	0.78	neutral	0.66	neutral	2.93	22.00	deleterious	0.49	0.55	0.36	neutral	0.5	neutral	0.42	neutral	0.43	neutral	1	1	deleterious	0.33	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.39	medium_impact	-0.5	medium_impact	0.61	0.8	4.31	11.73	0.23	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12760	12760	A	T	MI.20152	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	424	142	I	F	Atc/Ttc	-6.01	0	0	probably_damaging	1	neutral	0.86	neutral	4.44	neutral	-1.26	deleterious	-3.83	medium_impact	2.04	0.62	neutral	0.09	damaging	3.66	23.20	deleterious	0.28	0.45	0.65	disease	0.82	disease	0.66	disease	0.57	disease	1	1	deleterious	0.43	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.67	medium_impact	0.66	medium_impact	0.79	0.85	4.31	11.73	0.15	N	0.96	polymorphism	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12761	12761	T	C	MI.20153	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	425	142	I	T	aTc/aCc	3.85	0.99	0	probably_damaging	1	neutral	0.72	neutral	4.37	deleterious	-3.02	deleterious	-4.8	medium_impact	3.39	0.6	damaging	0.11	damaging	3.35	22.90	deleterious	0.31	0.45	0.78	disease	0.86	disease	0.62	disease	0.72	disease	4	1	deleterious	0.36	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.46	medium_impact	1.89	medium_impact	0.63	0.8	4.31	11.73	0.37	N	0.96	disease_causing	0.97	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12761	12761	T	A	MI.20154	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	425	142	I	N	aTc/aAc	3.85	0.99	0	probably_damaging	1	neutral	0.71	neutral	4.34	deleterious	-5.07	deleterious	-6.75	high_impact	4.43	0.59	damaging	0.11	damaging	4.40	24.10	deleterious	0.19	0.45	0.82	disease	0.91	disease	0.66	disease	0.75	disease	5	1	deleterious	0.36	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.45	medium_impact	2.84	high_impact	0.60	0.8	4.31	11.73	0.48	N	0.99	disease_causing	0.99	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12761	12761	T	G	MI.20155	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	425	142	I	S	aTc/aGc	3.85	0.99	0	probably_damaging	1	neutral	0.85	neutral	4.36	deleterious	-3.61	deleterious	-5.76	high_impact	4.43	0.62	neutral	0.12	damaging	4.22	23.90	deleterious	0.21	0.45	0.84	disease	0.91	disease	0.62	disease	0.74	disease	5	1	deleterious	0.43	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.65	medium_impact	2.84	high_impact	0.58	0.8	4.31	11.73	0.46	N	0.96	disease_causing	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12762	12762	C	A	MI.20156	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	426	142	I	M	atC/atA	5.69	1	0	probably_damaging	1	neutral	0.56	neutral	4.46	neutral	-2.46	deleterious	-2.69	medium_impact	2.65	0.66	neutral	0.75	neutral	3.72	23.30	deleterious	0.29	0.45	0.71	disease	0.76	disease	0.56	disease	0.63	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.29	medium_impact	1.22	medium_impact	0.76	0.85	4.31	11.73	0.4	N	0.76	disease_causing	0.99	0.07	rs28379632	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12762	12762	C	G	MI.20157	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	426	142	I	M	atC/atG	5.69	1	0	probably_damaging	1	neutral	0.56	neutral	4.46	neutral	-2.46	deleterious	-2.69	medium_impact	2.65	0.66	neutral	0.75	neutral	3.22	22.70	deleterious	0.29	0.45	0.71	disease	0.76	disease	0.56	disease	0.63	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.29	medium_impact	1.22	medium_impact	0.76	0.85	4.31	11.73	0.43	N	0.76	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12763	12763	G	A	MI.20158	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	427	143	G	S	Ggc/Agc	-5.55	0	0	probably_damaging	1	neutral	0.46	neutral	4.47	neutral	-2.92	deleterious	-5.87	high_impact	3.98	0.39	damaging	0.08	damaging	4.05	23.70	deleterious	0.34	0.5	0.72	disease	0.92	disease	0.65	disease	0.73	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.19	medium_impact	2.43	high_impact	0.81	0.85	28.03	7.18	0.45	N	1.00	disease_causing	0.54	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12763	12763	G	T	MI.20159	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	427	143	G	C	Ggc/Tgc	-5.55	0	0	probably_damaging	1	neutral	0.18	neutral	4.33	deleterious	-4.4	deleterious	-8.84	high_impact	3.92	0.42	damaging	0.05	damaging	4.00	23.60	deleterious	0.17	0.45	0.81	disease	0.96	disease	0.68	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.13	medium_impact	2.38	high_impact	0.55	0.8	28.03	7.18	0.36	N	0.97	disease_causing	0.83	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5968	5968	T	A	MI.2016	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	65	22	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.74	deleterious	-3.19	neutral	-1.19	high_impact	3.54	0.66	neutral	0.14	damaging	4.18	23.80	deleterious	0.31	0.55	0.6	disease	0.83	disease	0.56	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.35	low_impact	-1.48	low_impact	2.17	high_impact	0.70	0.9	2.92	6.69	0.52	P	0.59	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12763	12763	G	C	MI.20160	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	427	143	G	R	Ggc/Cgc	-5.55	0	0	probably_damaging	1	neutral	0.43	neutral	4.35	deleterious	-5.2	deleterious	-7.86	high_impact	4.32	0.47	damaging	0.06	damaging	3.78	23.40	deleterious	0.16	0.45	0.61	disease	0.96	disease	0.77	disease	0.87	disease	7	1	deleterious	0.22	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.17	medium_impact	2.74	high_impact	0.70	0.85	28.03	7.18	0.46	N	1.00	disease_causing	0.71	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12764	12764	G	A	MI.20161	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	428	143	G	D	gGc/gAc	5.92	1	0	probably_damaging	1	neutral	0.24	neutral	4.33	deleterious	-6.4	deleterious	-6.87	high_impact	5.01	0.51	damaging	0.07	damaging	3.71	23.30	deleterious	0.17	0.45	0.95	disease	0.94	disease	0.76	disease	0.85	disease	7	1	deleterious	0.12	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.04	medium_impact	3.37	high_impact	0.54	0.8	28.03	7.18	0.62	P	0.95	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12764	12764	G	C	MI.20162	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	428	143	G	A	gGc/gCc	5.92	1	0	probably_damaging	1	neutral	0.55	neutral	4.44	neutral	-1.31	deleterious	-5.89	high_impact	3.54	0.44	damaging	0.1	damaging	3.06	22.40	deleterious	0.37	0.5	0.51	disease	0.88	disease	0.63	disease	0.71	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.28	medium_impact	2.03	high_impact	0.79	0.85	28.03	7.18	0.55	P	0.79	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12764	12764	G	T	MI.20163	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	428	143	G	V	gGc/gTc	5.92	1	0	probably_damaging	1	neutral	0.59	neutral	4.41	neutral	-2.7	deleterious	-8.85	high_impact	4.12	0.35	damaging	0.05	damaging	3.69	23.30	deleterious	0.18	0.45	0.47	neutral	0.95	disease	0.67	disease	0.79	disease	6	1	deleterious	0.3	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.32	medium_impact	2.56	high_impact	0.50	0.8	28.03	7.18	0.61	P	0.98	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12766	12766	T	C	MI.20164	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	430	144	W	R	Tga/Cga	-9.68	0	0	probably_damaging	1	neutral	0.36	neutral	4.36	deleterious	-6.21	deleterious	-13.81	high_impact	5.2	0.48	damaging	0.03	damaging	3.54	23.10	deleterious	0.26	0.45	0.93	disease	0.95	disease	0.79	disease	0.85	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.1	medium_impact	3.55	high_impact	0.33	0.8	28.03	7.21	0.53	P	0.97	polymorphism	0.54	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12766	12766	T	G	MI.20165	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	430	144	W	G	Tga/Gga	-9.68	0	0	probably_damaging	1	neutral	0.4	neutral	4.36	deleterious	-6.34	deleterious	-12.83	high_impact	5.2	0.44	damaging	0.04	damaging	3.86	23.40	deleterious	0.22	0.45	0.94	disease	0.89	disease	0.74	disease	0.82	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.14	medium_impact	3.55	high_impact	0.30	0.8	28.03	7.21	0.51	P	0.97	disease_causing	0.7	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12767	12767	G	T	MI.20166	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	431	144	W	L	tGa/tTa	7.3	1	0	probably_damaging	1	neutral	0.71	neutral	4.63	neutral	-1.91	deleterious	-12.83	medium_impact	3.29	0.45	damaging	0.03	damaging	4.18	23.80	deleterious	0.25	0.45	0.55	disease	0.91	disease	0.71	disease	0.76	disease	5	1	deleterious	0.36	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.45	medium_impact	1.8	medium_impact	0.32	0.8	28.03	7.21	0.48	N	0.97	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12767	12767	G	C	MI.20167	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	431	144	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.44	neutral	4.37	deleterious	-5.12	deleterious	-13.81	high_impact	5.2	0.46	damaging	0.05	damaging	3.92	23.50	deleterious	0.21	0.45	0.87	disease	0.94	disease	0.73	disease	0.84	disease	7	1	deleterious	0.22	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.18	medium_impact	3.55	high_impact	0.27	0.8	28.03	7.21	0.54	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12768	12768	A	C	MI.20168	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	432	144	W	C	tgA/tgC	9.13	1	0	probably_damaging	1	neutral	0.18	neutral	4.36	deleterious	-6.58	deleterious	-12.83	high_impact	5.2	0.42	damaging	0.03	damaging	3.98	23.60	deleterious	0.27	0.45	0.95	disease	0.95	disease	0.76	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.13	medium_impact	3.55	high_impact	0.34	0.8	28.03	7.21	0.56	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12768	12768	A	T	MI.20169	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	432	144	W	C	tgA/tgT	9.13	1	0	probably_damaging	1	neutral	0.18	neutral	4.36	deleterious	-6.58	deleterious	-12.83	high_impact	5.2	0.42	damaging	0.03	damaging	4.08	23.70	deleterious	0.27	0.45	0.95	disease	0.95	disease	0.76	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.13	medium_impact	3.55	high_impact	0.34	0.8	28.03	7.21	0.57	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5969	5969	C	A	MI.2017	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	66	22	F	L	ttC/ttA	5.68	1	0	probably_damaging	0.98	neutral	0.21	neutral	2.91	neutral	-2.6	neutral	-1.98	low_impact	1.35	0.51	damaging	0.18	damaging	3.18	22.70	deleterious	0.32	0.55	0.19	neutral	0.72	disease	0.41	neutral	0.56	disease	1	0.99	deleterious	0.12	neutral	-2	neutral	0.72	deleterious	-2.35	low_impact	-0.13	medium_impact	0.15	medium_impact	0.56	0.9	2.92	6.69	0.58	P	0.83	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12769	12769	G	C	MI.20170	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	433	145	E	Q	Gag/Cag	0.18	0.96	0	probably_damaging	1	neutral	0.29	neutral	3.14	deleterious	-6.46	deleterious	-2.95	high_impact	5.04	0.29	damaging	0.15	damaging	3.32	22.90	deleterious	0.24	0.45	0.7	disease	0.83	disease	0.76	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.02	medium_impact	3.4	high_impact	0.71	0.85	26.7	7.22	0.86	P	0.89	disease_causing	0.99	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12769	12769	G	A	MI.20171	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	433	145	E	K	Gag/Aag	0.18	0.96	0	probably_damaging	1	neutral	0.29	neutral	3.14	deleterious	-6.47	deleterious	-3.92	high_impact	4.14	0.3	damaging	0.13	damaging	4.38	24.10	deleterious	0.19	0.45	0.88	disease	0.94	disease	0.78	disease	0.86	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.02	medium_impact	2.58	high_impact	0.73	0.85	26.7	7.22	0.73	P	0.99	disease_causing	1	0.42	rs879058074	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12770	12770	A	C	MI.20172	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	434	145	E	A	gAg/gCg	8.9	1	0	probably_damaging	1	neutral	0.52	neutral	3.14	deleterious	-6.58	deleterious	-5.91	high_impact	4.69	0.31	damaging	0.13	damaging	3.60	23.20	deleterious	0.2	0.45	0.91	disease	0.86	disease	0.74	disease	0.81	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.25	medium_impact	3.08	high_impact	0.59	0.8	26.7	7.22	0.81	P	0.75	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12770	12770	A	G	MI.20173	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	434	145	E	G	gAg/gGg	8.9	1	0	probably_damaging	1	neutral	0.41	neutral	3.18	deleterious	-5.24	deleterious	-6.89	high_impact	3.8	0.18	damaging	0.16	damaging	4.15	23.80	deleterious	0.24	0.45	0.9	disease	0.83	disease	0.75	disease	0.81	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.15	medium_impact	2.27	high_impact	0.38	0.8	26.7	7.22	0.91	P	0.51	disease_causing_automatic	1	0.42	rs267606894	Pathogenic	Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke	24738	MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003	.	.	.	.	A12770G	MELAS	-	+	Reported	4	P	P	P	damaging
chrM	12770	12770	A	T	MI.20174	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	434	145	E	V	gAg/gTg	8.9	1	0	probably_damaging	1	neutral	0.53	neutral	3.12	deleterious	-8.28	deleterious	-6.89	high_impact	5.04	0.22	damaging	0.1	damaging	4.09	23.70	deleterious	0.19	0.45	0.96	disease	0.93	disease	0.76	disease	0.83	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.26	medium_impact	3.4	high_impact	0.63	0.8	26.7	7.22	0.8	P	0.81	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12771	12771	G	C	MI.20175	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	435	145	E	D	gaG/gaC	8.44	1	0.1	probably_damaging	1	neutral	0.2	neutral	3.28	deleterious	-3.93	deleterious	-2.96	medium_impact	2.42	0.4	damaging	0.13	damaging	3.62	23.20	deleterious	0.28	0.45	0.83	disease	0.81	disease	0.77	disease	0.76	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.1	medium_impact	1.01	medium_impact	0.76	0.85	26.7	7.22	0.71	P	0.86	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12771	12771	G	T	MI.20176	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	435	145	E	D	gaG/gaT	8.44	1	0.1	probably_damaging	1	neutral	0.2	neutral	3.28	deleterious	-3.93	deleterious	-2.96	medium_impact	2.42	0.4	damaging	0.13	damaging	3.78	23.40	deleterious	0.28	0.45	0.83	disease	0.81	disease	0.77	disease	0.76	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.1	medium_impact	1.01	medium_impact	0.76	0.85	26.7	7.22	0.71	P	0.86	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12772	12772	G	A	MI.20177	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	436	146	G	S	Ggc/Agc	-2.34	0	0	probably_damaging	1	neutral	0.89	neutral	4.58	neutral	-2.87	deleterious	-5.87	high_impact	4.56	0.5	damaging	0.11	damaging	4.16	23.80	deleterious	0.35	0.5	0.8	disease	0.88	disease	0.53	disease	0.72	disease	4	1	deleterious	0.45	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.73	medium_impact	2.96	high_impact	0.74	0.85	29.35	7.17	0.38	N	1.00	disease_causing	1	0.20	rs879130607	.	.	.	.	.	COSM1155529	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12772	12772	G	C	MI.20178	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	436	146	G	R	Ggc/Cgc	-2.34	0	0	probably_damaging	1	neutral	0.68	neutral	4.54	deleterious	-4.53	deleterious	-7.86	high_impact	4.91	0.67	neutral	0.06	damaging	3.89	23.50	deleterious	0.06	0.35	0.92	disease	0.95	disease	0.74	disease	0.83	disease	7	1	deleterious	0.34	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.41	medium_impact	3.28	high_impact	0.62	0.8	29.35	7.17	0.62	P	1.00	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12772	12772	G	T	MI.20179	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	436	146	G	C	Ggc/Tgc	-2.34	0	0	probably_damaging	1	neutral	0.2	neutral	4.55	deleterious	-4.39	deleterious	-8.84	high_impact	4.56	0.63	neutral	0.06	damaging	4.03	23.70	deleterious	0.11	0.4	0.83	disease	0.94	disease	0.64	disease	0.77	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.1	medium_impact	2.96	high_impact	0.68	0.85	29.35	7.17	0.44	N	0.97	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5969	5969	C	G	MI.2018	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	66	22	F	L	ttC/ttG	5.68	1	0	probably_damaging	0.98	neutral	0.21	neutral	2.91	neutral	-2.6	neutral	-1.98	low_impact	1.35	0.51	damaging	0.18	damaging	2.90	21.80	deleterious	0.32	0.55	0.19	neutral	0.72	disease	0.41	neutral	0.56	disease	1	0.99	deleterious	0.12	neutral	-2	neutral	0.72	deleterious	-2.35	low_impact	-0.13	medium_impact	0.15	medium_impact	0.56	0.9	2.92	6.69	0.58	P	0.83	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12773	12773	G	A	MI.20180	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	437	146	G	D	gGc/gAc	7.3	1	0	probably_damaging	1	neutral	0.67	neutral	4.52	deleterious	-5.45	deleterious	-6.87	high_impact	4.91	0.75	neutral	0.07	damaging	3.69	23.30	deleterious	0.08	0.35	0.68	disease	0.93	disease	0.71	disease	0.8	disease	6	1	deleterious	0.34	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.4	medium_impact	3.28	high_impact	0.50	0.8	29.35	7.17	0.67	P	0.95	disease_causing	1	0.39	.	.	.	.	.	.	COSM1132240	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12773	12773	G	C	MI.20181	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	437	146	G	A	gGc/gCc	7.3	1	0	probably_damaging	1	neutral	0.97	neutral	4.64	neutral	-0.72	deleterious	-5.89	medium_impact	2.56	0.52	damaging	0.25	damaging	3.03	22.30	deleterious	0.48	0.55	0.64	disease	0.83	disease	0.57	disease	0.53	disease	1	1	deleterious	0.49	deleterious	1	deleterious	0.81	deleterious	-3.6	low_impact	1.07	medium_impact	1.14	medium_impact	0.77	0.85	29.35	7.17	0.43	N	0.79	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12773	12773	G	T	MI.20182	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	437	146	G	V	gGc/gTc	7.3	1	0	probably_damaging	1	neutral	0.64	neutral	4.67	neutral	-0.44	deleterious	-8.85	medium_impact	3.46	0.56	damaging	0.06	damaging	3.72	23.30	deleterious	0.11	0.4	0.68	disease	0.94	disease	0.6	disease	0.77	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.37	medium_impact	1.96	medium_impact	0.67	0.85	29.35	7.17	0.38	N	0.98	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12775	12775	G	C	MI.20183	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	439	147	V	L	Gta/Cta	-8.53	0	0	possibly_damaging	0.61	neutral	0.69	neutral	4.69	neutral	-1.06	deleterious	-2.77	medium_impact	2.04	0.33	damaging	0.44	neutral	3.52	23.10	deleterious	0.53	0.6	0.43	neutral	0.82	disease	0.61	disease	0.64	disease	3	0.53	neutral	0.54	deleterious	0	NA	0.75	deleterious	-0.93	medium_impact	0.42	medium_impact	0.66	medium_impact	0.61	0.8	9.29	16.45	0.59	P	0.77	polymorphism	0.98	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12775	12775	G	A	MI.20184	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	439	147	V	M	Gta/Ata	-8.53	0	0	benign	0.4	neutral	0.26	neutral	4.48	neutral	-0.79	deleterious	-2.63	medium_impact	2.37	0.49	damaging	0.63	neutral	3.57	23.20	deleterious	0.52	0.6	0.61	disease	0.81	disease	0.58	disease	0.62	disease	2	0.7	neutral	0.43	neutral	-3	neutral	0.74	deleterious	-0.58	medium_impact	-0.02	medium_impact	0.96	medium_impact	0.75	0.85	9.29	16.45	0.4	N	0.95	polymorphism	0.98	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12775	12775	G	T	MI.20185	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	439	147	V	L	Gta/Tta	-8.53	0	0	possibly_damaging	0.61	neutral	0.69	neutral	4.69	neutral	-1.06	deleterious	-2.77	medium_impact	2.04	0.33	damaging	0.44	neutral	3.64	23.20	deleterious	0.53	0.6	0.43	neutral	0.82	disease	0.61	disease	0.64	disease	3	0.53	neutral	0.54	deleterious	0	NA	0.75	deleterious	-0.93	medium_impact	0.42	medium_impact	0.66	medium_impact	0.61	0.8	9.29	16.45	0.6	P	0.77	polymorphism	0.98	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12776	12776	T	G	MI.20186	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	440	147	V	G	gTa/gGa	7.3	1	0	probably_damaging	0.95	neutral	0.42	neutral	4.49	deleterious	-4.4	deleterious	-6.75	high_impact	4.75	0.41	damaging	0.51	neutral	3.74	23.30	deleterious	0.28	0.45	0.92	disease	0.84	disease	0.68	disease	0.81	disease	6	0.95	neutral	0.24	neutral	2	deleterious	0.81	deleterious	-1.96	low_impact	0.16	medium_impact	3.14	high_impact	0.41	0.8	9.29	16.45	0.79	P	0.89	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12776	12776	T	A	MI.20187	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	440	147	V	E	gTa/gAa	7.3	1	0	probably_damaging	0.97	neutral	0.3	neutral	4.49	deleterious	-4.14	deleterious	-5.77	high_impact	4.75	0.43	damaging	0.42	neutral	4.56	24.40	deleterious	0.18	0.45	0.79	disease	0.91	disease	0.76	disease	0.81	disease	6	0.97	neutral	0.17	neutral	2	deleterious	0.86	deleterious	-2.18	low_impact	0.03	medium_impact	3.14	high_impact	0.46	0.8	9.29	16.45	0.8	P	0.97	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12776	12776	T	C	MI.20188	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	440	147	V	A	gTa/gCa	7.3	1	0	possibly_damaging	0.73	neutral	0.51	neutral	4.5	neutral	-2.15	deleterious	-3.85	high_impact	4.4	0.36	damaging	0.51	neutral	3.48	23.10	deleterious	0.48	0.55	0.67	disease	0.76	disease	0.64	disease	0.66	disease	3	0.7	neutral	0.39	neutral	1	deleterious	0.78	deleterious	-1.16	low_impact	0.24	medium_impact	2.82	high_impact	0.31	0.8	9.29	16.45	0.8	P	0.52	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12778	12778	G	C	MI.20189	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	442	148	G	R	Gga/Cga	-11.97	0	0	probably_damaging	1	neutral	0.36	neutral	4.39	deleterious	-4.27	deleterious	-7.89	high_impact	4.76	0.33	damaging	0.22	damaging	3.83	23.40	deleterious	0.07	0.35	0.82	disease	0.94	disease	0.8	disease	0.89	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.1	medium_impact	3.15	high_impact	0.77	0.85	29.85	7.26	0.67	P	1.00	polymorphism	0.82	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5970	5970	G	C	MI.2019	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	67	23	G	R	Ggc/Cgc	-3.81	0	0	probably_damaging	0.98	deleterious	0	neutral	2.65	deleterious	-5.31	deleterious	-3.55	high_impact	4.04	0.57	damaging	0.19	damaging	3.75	23.30	deleterious	0.09	0.55	0.51	disease	0.93	disease	0.71	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.35	low_impact	-1.48	low_impact	2.63	high_impact	0.70	0.9	3.31	7.62	0.32	N	0.88	disease_causing	0.97	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12778	12778	G	T	MI.20190	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	442	148	G	W	Gga/Tga	-11.97	0	0	probably_damaging	1	neutral	0.2	neutral	4.36	deleterious	-6.68	deleterious	-7.89	high_impact	5.11	0.33	damaging	0.21	damaging	4.28	24.00	deleterious	0.12	0.4	0.98	disease	0.95	disease	0.74	disease	0.83	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.1	medium_impact	3.47	high_impact	0.48	0.8	29.85	7.26	0.58	P	1.00	polymorphism	0.73	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12779	12779	G	A	MI.20191	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	443	148	G	E	gGa/gAa	5.92	1	0	probably_damaging	1	neutral	0.29	neutral	4.41	deleterious	-3.65	deleterious	-7.89	high_impact	5.11	0.26	damaging	0.25	damaging	3.81	23.40	deleterious	0.1	0.4	0.74	disease	0.93	disease	0.78	disease	0.83	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.02	medium_impact	3.47	high_impact	0.75	0.85	29.85	7.26	0.9	P	1.00	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12779	12779	G	T	MI.20192	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	443	148	G	V	gGa/gTa	5.92	1	0	probably_damaging	1	neutral	0.53	neutral	4.42	neutral	-2.83	deleterious	-8.88	high_impact	5.11	0.23	damaging	0.27	damaging	3.67	23.20	deleterious	0.11	0.4	0.79	disease	0.94	disease	0.7	disease	0.8	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.26	medium_impact	3.47	high_impact	0.61	0.8	29.85	7.26	0.88	P	0.98	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12779	12779	G	C	MI.20193	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	443	148	G	A	gGa/gCa	5.92	1	0	probably_damaging	1	neutral	0.52	neutral	4.43	neutral	-2.05	deleterious	-5.92	high_impact	4.76	0.35	damaging	0.38	neutral	3.03	22.30	deleterious	0.44	0.55	0.75	disease	0.86	disease	0.68	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.25	medium_impact	3.15	high_impact	0.80	0.85	29.85	7.26	0.83	P	0.79	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12781	12781	A	G	MI.20194	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	445	149	I	V	Att/Gtt	-3.26	0	0	probably_damaging	1	neutral	0.57	neutral	4.61	neutral	-0.72	neutral	-0.97	low_impact	0.94	0.81	neutral	0.67	neutral	2.95	22.10	deleterious	0.59	0.65	0.57	disease	0.4	neutral	0.6	disease	0.61	disease	2	1	deleterious	0.29	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.3	medium_impact	-0.34	medium_impact	0.64	0.8	10.28	7.1	0.26	N	0.74	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12781	12781	A	T	MI.20195	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	445	149	I	F	Att/Ttt	-3.26	0	0	probably_damaging	1	neutral	0.77	neutral	4.54	neutral	-2.99	deleterious	-3.92	low_impact	1.45	0.69	neutral	0.38	neutral	3.77	23.40	deleterious	0.37	0.5	0.87	disease	0.74	disease	0.69	disease	0.73	disease	5	1	deleterious	0.39	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.52	medium_impact	0.12	medium_impact	0.73	0.85	10.28	7.1	0.19	N	0.96	disease_causing	0.53	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12781	12781	A	C	MI.20196	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	445	149	I	L	Att/Ctt	-3.26	0	0	probably_damaging	1	neutral	0.73	neutral	4.84	neutral	1.06	neutral	-1.95	neutral_impact	0.5	0.69	neutral	0.67	neutral	3.73	23.30	deleterious	0.42	0.55	0.37	neutral	0.42	neutral	0.62	disease	0.43	neutral	1	1	deleterious	0.37	neutral	-2	neutral	0.62	deleterious	-3.6	low_impact	0.47	medium_impact	-0.75	medium_impact	0.75	0.85	10.28	7.1	0.29	N	0.86	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12782	12782	T	C	MI.20197	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	446	149	I	T	aTt/aCt	6.84	1	0	probably_damaging	1	neutral	0.39	neutral	4.52	deleterious	-3.65	deleterious	-4.9	high_impact	4.21	0.71	neutral	0.39	neutral	3.41	23.00	deleterious	0.5	0.6	0.85	disease	0.66	disease	0.66	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.13	medium_impact	2.64	high_impact	0.65	0.8	10.28	7.1	0.6	P	0.96	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12782	12782	T	A	MI.20198	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	446	149	I	N	aTt/aAt	6.84	1	0	probably_damaging	1	neutral	0.33	neutral	4.44	deleterious	-5.38	deleterious	-6.87	high_impact	3.87	0.68	neutral	0.4	neutral	4.49	24.30	deleterious	0.34	0.5	0.94	disease	0.82	disease	0.69	disease	0.82	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.06	medium_impact	2.33	high_impact	0.54	0.8	10.28	7.1	0.56	P	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12782	12782	T	G	MI.20199	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	446	149	I	S	aTt/aGt	6.84	1	0	probably_damaging	1	neutral	0.45	neutral	4.47	deleterious	-3.59	deleterious	-5.88	high_impact	4.21	0.73	neutral	0.42	neutral	4.23	23.90	deleterious	0.3	0.45	0.62	disease	0.78	disease	0.66	disease	0.68	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.74	deleterious	-3.6	low_impact	0.18	medium_impact	2.64	high_impact	0.48	0.8	10.28	7.1	0.55	P	0.96	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	T12782G	LHON	-	+	Reported	1	.	P	P	damaging
chrM	8620	8620	C	A	MI.202	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	94	32	P	T	Ccc/Acc	-6.35	0	0	probably_damaging	1	neutral	0.14	neutral	4.53	neutral	2.72	deleterious	-6.1	low_impact	1.9	0.89	neutral	0.73	neutral	3.46	23.00	deleterious	0.46	0.65	0.53	disease	0.68	disease	0.35	neutral	0.51	disease	0	1	deleterious	0.07	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	-0.15	medium_impact	0.53	medium_impact	0.52	0.9	29.2	19.38	0.41	N	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5970	5970	G	A	MI.2020	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	67	23	G	S	Ggc/Agc	-3.81	0	0	benign	0.27	deleterious	0.04	neutral	2.88	neutral	-0.63	deleterious	-2.62	low_impact	1.78	0.52	damaging	0.28	damaging	4.00	23.60	deleterious	0.31	0.55	0.2	neutral	0.76	disease	0.35	neutral	0.55	disease	1	0.95	neutral	0.39	neutral	-2	neutral	0.27	neutral	-0.35	medium_impact	-0.58	medium_impact	0.55	medium_impact	0.78	0.9	3.31	7.62	0.37	N	0.68	disease_causing	0.94	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12783	12783	T	A	MI.20200	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	447	149	I	M	atT/atA	7.3	1	0	probably_damaging	1	neutral	0.24	neutral	4.51	deleterious	-3.18	deleterious	-2.9	low_impact	1.65	0.74	neutral	0.53	neutral	3.67	23.30	deleterious	0.48	0.55	0.78	disease	0.53	disease	0.6	disease	0.57	disease	1	1	deleterious	0.12	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	-0.04	medium_impact	0.3	medium_impact	0.82	0.85	10.28	7.1	0.55	P	0.76	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12783	12783	T	G	MI.20201	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	447	149	I	M	atT/atG	7.3	1	0	probably_damaging	1	neutral	0.24	neutral	4.51	deleterious	-3.18	deleterious	-2.9	low_impact	1.65	0.74	neutral	0.53	neutral	3.34	22.90	deleterious	0.48	0.55	0.78	disease	0.53	disease	0.6	disease	0.57	disease	1	1	deleterious	0.12	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	-0.04	medium_impact	0.3	medium_impact	0.82	0.85	10.28	7.1	0.54	P	0.76	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12784	12784	A	C	MI.20202	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	448	150	M	L	Ata/Cta	-3.49	0	0	probably_damaging	0.98	neutral	0.91	neutral	4.74	neutral	0.65	deleterious	-2.96	low_impact	0.94	0.49	damaging	0.09	damaging	3.24	22.80	deleterious	0.49	0.55	0.43	neutral	0.89	disease	0.69	disease	0.56	disease	1	0.98	deleterious	0.47	neutral	-2	neutral	0.67	deleterious	-2.35	low_impact	0.79	medium_impact	-0.34	medium_impact	0.52	0.8	28.03	7.19	0.23	N	0.98	disease_causing	0.65	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12784	12784	A	T	MI.20203	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	448	150	M	L	Ata/Tta	-3.49	0	0	probably_damaging	0.98	neutral	0.91	neutral	4.74	neutral	0.65	deleterious	-2.96	low_impact	0.94	0.49	damaging	0.09	damaging	3.31	22.90	deleterious	0.49	0.55	0.43	neutral	0.89	disease	0.69	disease	0.56	disease	1	0.98	deleterious	0.47	neutral	-2	neutral	0.67	deleterious	-2.35	low_impact	0.79	medium_impact	-0.34	medium_impact	0.52	0.8	28.03	7.19	0.24	N	0.98	disease_causing	0.65	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12784	12784	A	G	MI.20204	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	448	150	M	V	Ata/Gta	-3.49	0	0	probably_damaging	0.99	neutral	0.6	neutral	4.72	neutral	1	deleterious	-3.95	low_impact	1.54	0.46	damaging	0.05	damaging	2.72	20.90	deleterious	0.58	0.65	0.6	disease	0.9	disease	0.74	disease	0.67	disease	3	0.99	deleterious	0.31	neutral	-2	neutral	0.72	deleterious	-2.64	low_impact	0.33	medium_impact	0.2	medium_impact	0.62	0.8	28.03	7.19	0.26	N	0.95	disease_causing	0.7	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12785	12785	T	A	MI.20205	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	449	150	M	K	aTa/aAa	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	4.6	neutral	-2.19	deleterious	-5.92	high_impact	3.87	0.52	damaging	0.03	damaging	3.83	23.40	deleterious	0.24	0.45	0.86	disease	0.94	disease	0.8	disease	0.89	disease	8	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.03	medium_impact	2.33	high_impact	0.61	0.8	28.03	7.19	0.62	P	1.00	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12785	12785	T	C	MI.20206	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	449	150	M	T	aTa/aCa	8.44	1	0	probably_damaging	1	neutral	0.41	neutral	4.67	neutral	0.57	deleterious	-5.92	low_impact	1.39	0.46	damaging	0.06	damaging	2.81	21.40	deleterious	0.53	0.6	0.48	neutral	0.91	disease	0.74	disease	0.79	disease	6	1	deleterious	0.21	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	0.15	medium_impact	0.07	medium_impact	0.48	0.8	28.03	7.19	0.44	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12786	12786	A	C	MI.20207	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	450	150	M	I	atA/atC	4.54	1	0	probably_damaging	0.99	neutral	0.56	neutral	4.69	neutral	0.25	deleterious	-3.95	low_impact	1.73	0.49	damaging	0.06	damaging	3.39	23.00	deleterious	0.5	0.6	0.61	disease	0.94	disease	0.71	disease	0.83	disease	7	0.99	deleterious	0.29	neutral	-2	neutral	0.80	deleterious	-2.64	low_impact	0.29	medium_impact	0.38	medium_impact	0.57	0.8	28.03	7.19	0.43	N	0.94	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12786	12786	A	T	MI.20208	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	450	150	M	I	atA/atT	4.54	1	0	probably_damaging	0.99	neutral	0.56	neutral	4.69	neutral	0.25	deleterious	-3.95	low_impact	1.73	0.49	damaging	0.06	damaging	3.42	23.00	deleterious	0.5	0.6	0.61	disease	0.94	disease	0.71	disease	0.83	disease	7	0.99	deleterious	0.29	neutral	-2	neutral	0.80	deleterious	-2.64	low_impact	0.29	medium_impact	0.38	medium_impact	0.57	0.8	28.03	7.19	0.44	N	0.94	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12787	12787	T	C	MI.20209	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	451	151	S	P	Tcc/Ccc	-0.04	0.74	0	probably_damaging	1	neutral	0.2	neutral	4.32	deleterious	-6.35	deleterious	-4.93	high_impact	4.87	0.36	damaging	0.48	neutral	3.86	23.50	deleterious	0.22	0.45	0.96	disease	0.86	disease	0.81	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.1	medium_impact	3.25	high_impact	0.66	0.8	30.35	7.21	0.81	P	0.98	disease_causing	0.98	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5970	5970	G	T	MI.2021	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	67	23	G	C	Ggc/Tgc	-3.81	0	0	probably_damaging	0.98	deleterious	0	neutral	2.66	deleterious	-4.15	deleterious	-3.97	high_impact	4.04	0.55	damaging	0.21	damaging	4.00	23.60	deleterious	0.17	0.55	0.78	disease	0.93	disease	0.59	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.35	low_impact	-1.48	low_impact	2.63	high_impact	0.64	0.9	3.31	7.62	0.33	N	0.70	disease_causing	0.98	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12787	12787	T	A	MI.20210	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	451	151	S	T	Tcc/Acc	-0.04	0.74	0	probably_damaging	1	neutral	0.39	neutral	4.45	deleterious	-3.08	deleterious	-2.96	high_impact	3.71	0.33	damaging	0.35	neutral	3.67	23.30	deleterious	0.31	0.45	0.72	disease	0.74	disease	0.7	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.13	medium_impact	2.19	high_impact	0.82	0.85	30.35	7.21	0.62	P	0.71	disease_causing	0.88	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12787	12787	T	G	MI.20211	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	451	151	S	A	Tcc/Gcc	-0.04	0.74	0	probably_damaging	1	neutral	0.51	neutral	4.41	deleterious	-3.57	deleterious	-2.96	high_impact	5.21	0.34	damaging	0.46	neutral	3.58	23.20	deleterious	0.32	0.5	0.78	disease	0.76	disease	0.7	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.24	medium_impact	3.56	high_impact	0.79	0.85	30.35	7.21	0.76	P	0.49	disease_causing	0.69	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12788	12788	C	A	MI.20212	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	452	151	S	Y	tCc/tAc	5.69	1	0	probably_damaging	1	neutral	1	neutral	4.33	deleterious	-5.35	deleterious	-5.92	high_impact	5.21	0.31	damaging	0.31	neutral	4.12	23.80	deleterious	0.19	0.45	0.93	disease	0.91	disease	0.74	disease	0.83	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.86	deleterious	-3.6	low_impact	1.89	high_impact	3.56	high_impact	0.68	0.85	30.35	7.21	0.76	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12788	12788	C	T	MI.20213	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	452	151	S	F	tCc/tTc	5.69	1	0	probably_damaging	1	neutral	0.7	neutral	4.4	deleterious	-4.82	deleterious	-5.92	high_impact	4.87	0.25	damaging	0.31	neutral	4.12	23.80	deleterious	0.19	0.45	0.81	disease	0.91	disease	0.73	disease	0.79	disease	6	1	deleterious	0.35	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.44	medium_impact	3.25	high_impact	0.49	0.8	30.35	7.21	0.89	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12788	12788	C	G	MI.20214	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	452	151	S	C	tCc/tGc	5.69	1	0	probably_damaging	1	neutral	0.18	neutral	4.32	deleterious	-6.54	deleterious	-4.93	high_impact	5.21	0.3	damaging	0.36	neutral	3.48	23.10	deleterious	0.24	0.45	0.96	disease	0.85	disease	0.7	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.13	medium_impact	3.56	high_impact	0.65	0.8	30.35	7.21	0.78	P	0.99	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12790	12790	T	C	MI.20215	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	454	152	F	L	Ttc/Ctc	-12.43	0	0	probably_damaging	1	neutral	0.77	neutral	4.68	neutral	-1.75	deleterious	-5.91	medium_impact	3.24	0.49	damaging	0.03	damaging	4.01	23.60	deleterious	0.33	0.5	0.62	disease	0.82	disease	0.66	disease	0.68	disease	4	1	deleterious	0.39	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.52	medium_impact	1.76	medium_impact	0.72	0.85	28.86	7.16	0.26	N	0.92	polymorphism	0.93	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12790	12790	T	A	MI.20216	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	454	152	F	I	Ttc/Atc	-12.43	0	0	probably_damaging	1	neutral	0.54	neutral	4.51	neutral	-2.63	deleterious	-5.91	high_impact	4.68	0.49	damaging	0.06	damaging	4.37	24.10	deleterious	0.19	0.45	0.75	disease	0.88	disease	0.71	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.27	medium_impact	3.07	high_impact	0.61	0.8	28.86	7.16	0.52	N	0.95	polymorphism	0.93	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12790	12790	T	G	MI.20217	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	454	152	F	V	Ttc/Gtc	-12.43	0	0	probably_damaging	1	neutral	0.68	neutral	4.5	neutral	-1.77	deleterious	-6.89	high_impact	4.68	0.46	damaging	0.04	damaging	4.06	23.70	deleterious	0.3	0.45	0.59	disease	0.87	disease	0.72	disease	0.78	disease	6	1	deleterious	0.34	neutral	2	deleterious	0.75	deleterious	-3.6	low_impact	0.41	medium_impact	3.07	high_impact	0.64	0.8	28.86	7.16	0.49	N	0.95	polymorphism	0.87	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12791	12791	T	C	MI.20218	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	455	152	F	S	tTc/tCc	7.3	1	0	probably_damaging	1	neutral	0.53	neutral	4.39	deleterious	-3.2	deleterious	-7.88	high_impact	4.34	0.51	damaging	0.05	damaging	4.15	23.80	deleterious	0.24	0.45	0.84	disease	0.84	disease	0.7	disease	0.78	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.26	medium_impact	2.76	high_impact	0.55	0.8	28.86	7.16	0.53	P	0.97	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12791	12791	T	G	MI.20219	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	455	152	F	C	tTc/tGc	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	4.38	deleterious	-4.3	deleterious	-7.86	high_impact	4.68	0.53	damaging	0.04	damaging	4.02	23.60	deleterious	0.26	0.45	0.92	disease	0.88	disease	0.72	disease	0.83	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	-0.13	medium_impact	3.07	high_impact	0.36	0.8	28.86	7.16	0.6	P	0.99	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5971	5971	G	T	MI.2022	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	68	23	G	V	gGc/gTc	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.7	neutral	-2.58	deleterious	-3.97	high_impact	4.04	0.54	damaging	0.24	damaging	3.61	23.20	deleterious	0.17	0.55	0.4	neutral	0.9	disease	0.61	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.35	low_impact	-1.48	low_impact	2.63	high_impact	0.59	0.9	3.31	7.62	0.45	N	0.81	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12791	12791	T	A	MI.20220	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	455	152	F	Y	tTc/tAc	7.3	1	0	probably_damaging	1	neutral	1	neutral	4.81	neutral	1.65	deleterious	-2.96	neutral_impact	0.72	0.48	damaging	0.08	damaging	4.14	23.80	deleterious	0.21	0.45	0.37	neutral	0.54	disease	0.65	disease	0.47	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.70	deleterious	-3.6	low_impact	1.89	high_impact	-0.55	medium_impact	0.59	0.8	28.86	7.16	0.53	P	0.88	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12792	12792	C	A	MI.20221	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	456	152	F	L	ttC/ttA	5.69	1	0	probably_damaging	1	neutral	0.77	neutral	4.68	neutral	-1.75	deleterious	-5.91	medium_impact	3.24	0.49	damaging	0.03	damaging	4.61	24.40	deleterious	0.33	0.5	0.62	disease	0.82	disease	0.66	disease	0.68	disease	4	1	deleterious	0.39	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.52	medium_impact	1.76	medium_impact	0.72	0.85	28.86	7.16	0.5	N	0.92	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12792	12792	C	G	MI.20222	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	456	152	F	L	ttC/ttG	5.69	1	0	probably_damaging	1	neutral	0.77	neutral	4.68	neutral	-1.75	deleterious	-5.91	medium_impact	3.24	0.49	damaging	0.03	damaging	4.31	24.00	deleterious	0.33	0.5	0.62	disease	0.82	disease	0.66	disease	0.68	disease	4	1	deleterious	0.39	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.52	medium_impact	1.76	medium_impact	0.72	0.85	28.86	7.16	0.5	N	0.92	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12793	12793	T	A	MI.20223	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	457	153	L	M	Ttg/Atg	-3.26	0	0	probably_damaging	1	neutral	0.29	neutral	4.29	deleterious	-4.12	neutral	-1.75	medium_impact	2.52	0.61	neutral	0.67	neutral	2.24	17.75	deleterious	0.26	0.45	0.85	disease	0.42	neutral	0.4	neutral	0.59	disease	2	1	deleterious	0.15	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.02	medium_impact	1.1	medium_impact	0.65	0.8	12.27	14.39	0.37	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12793	12793	T	G	MI.20224	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	457	153	L	V	Ttg/Gtg	-3.26	0	0	probably_damaging	1	neutral	0.57	neutral	4.41	neutral	-2.17	deleterious	-2.87	medium_impact	2.98	0.5	damaging	0.09	damaging	3.29	22.80	deleterious	0.22	0.45	0.78	disease	0.64	disease	0.62	disease	0.67	disease	3	1	deleterious	0.29	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.3	medium_impact	1.52	medium_impact	0.57	0.8	12.27	14.39	0.22	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12794	12794	T	G	MI.20225	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	458	153	L	W	tTg/tGg	-1.42	0	0	probably_damaging	1	neutral	0.19	neutral	4.25	deleterious	-6.85	deleterious	-5.79	high_impact	4.57	0.6	damaging	0.1	damaging	3.72	23.30	deleterious	0.11	0.4	0.98	disease	0.8	disease	0.65	disease	0.83	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.12	medium_impact	2.97	high_impact	0.52	0.8	12.27	14.39	0.4	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12794	12794	T	C	MI.20226	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	458	153	L	S	tTg/tCg	-1.42	0	0	probably_damaging	1	neutral	0.51	neutral	4.29	deleterious	-4.83	deleterious	-5.79	high_impact	4.37	0.56	damaging	0.1	damaging	3.69	23.30	deleterious	0.15	0.4	0.92	disease	0.75	disease	0.63	disease	0.8	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.24	medium_impact	2.79	high_impact	0.59	0.8	12.27	14.39	0.32	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12795	12795	G	C	MI.20227	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	459	153	L	F	ttG/ttC	4.54	0.64	0	probably_damaging	1	neutral	0.81	neutral	4.34	neutral	-2.19	deleterious	-3.86	medium_impact	2.44	0.51	damaging	0.08	damaging	3.38	22.90	deleterious	0.22	0.45	0.75	disease	0.73	disease	0.61	disease	0.67	disease	3	1	deleterious	0.41	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.58	medium_impact	1.03	medium_impact	0.55	0.8	12.27	14.39	0.28	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12795	12795	G	T	MI.20228	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	459	153	L	F	ttG/ttT	4.54	0.64	0	probably_damaging	1	neutral	0.81	neutral	4.34	neutral	-2.19	deleterious	-3.86	medium_impact	2.44	0.51	damaging	0.08	damaging	3.54	23.10	deleterious	0.22	0.45	0.75	disease	0.73	disease	0.61	disease	0.67	disease	3	1	deleterious	0.41	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.58	medium_impact	1.03	medium_impact	0.55	0.8	12.27	14.39	0.3	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12796	12796	C	G	MI.20229	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	460	154	L	V	Ctc/Gtc	-6.93	0	0	probably_damaging	1	neutral	0.5	neutral	4.02	deleterious	-5.06	deleterious	-2.95	high_impact	5.24	0.18	damaging	0.32	neutral	3.39	23.00	deleterious	0.22	0.45	0.9	disease	0.7	disease	0.72	disease	0.78	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.23	medium_impact	3.58	high_impact	0.68	0.85	26.04	7.16	0.88	P	0.81	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5971	5971	G	C	MI.2023	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	68	23	G	A	gGc/gCc	7.53	1	0	possibly_damaging	0.44	neutral	0.07	neutral	3.29	neutral	1	deleterious	-2.56	low_impact	1.94	0.59	damaging	0.4	neutral	2.97	22.10	deleterious	0.41	0.55	0.18	neutral	0.54	disease	0.31	neutral	0.41	neutral	2	0.92	neutral	0.32	neutral	-3	neutral	0.48	deleterious	-0.66	medium_impact	-0.43	medium_impact	0.69	medium_impact	0.75	0.9	3.31	7.62	0.56	P	0.59	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12796	12796	C	T	MI.20230	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	460	154	L	F	Ctc/Ttc	-6.93	0	0	probably_damaging	1	neutral	0.75	neutral	3.92	deleterious	-6.19	deleterious	-3.94	high_impact	5.24	0.21	damaging	0.34	neutral	3.92	23.50	deleterious	0.18	0.45	0.95	disease	0.78	disease	0.72	disease	0.82	disease	6	1	deleterious	0.38	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.5	medium_impact	3.58	high_impact	0.58	0.8	26.04	7.16	0.86	P	0.99	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12796	12796	C	A	MI.20231	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	460	154	L	I	Ctc/Atc	-6.93	0	0	probably_damaging	1	neutral	0.78	neutral	4.01	deleterious	-4.24	neutral	-1.97	high_impact	4.43	0.24	damaging	0.49	neutral	4.05	23.70	deleterious	0.22	0.45	0.68	disease	0.77	disease	0.65	disease	0.67	disease	3	1	deleterious	0.39	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.54	medium_impact	2.84	high_impact	0.64	0.8	26.04	7.16	0.87	P	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12797	12797	T	G	MI.20232	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	461	154	L	R	cTc/cGc	-0.96	0	0	probably_damaging	1	neutral	0.36	neutral	3.89	deleterious	-7.75	deleterious	-5.91	high_impact	5.24	0.27	damaging	0.28	damaging	4.15	23.80	deleterious	0.09	0.35	0.99	disease	0.89	disease	0.8	disease	0.89	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.1	medium_impact	3.58	high_impact	0.39	0.8	26.04	7.16	0.86	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12797	12797	T	C	MI.20233	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	461	154	L	P	cTc/cCc	-0.96	0	0	probably_damaging	1	neutral	0.16	neutral	3.95	deleterious	-8.27	deleterious	-6.88	high_impact	5.24	0.15	damaging	0.36	neutral	3.84	23.40	deleterious	0.08	0.35	0.99	disease	0.83	disease	0.8	disease	0.89	disease	8	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.17	medium_impact	3.58	high_impact	0.41	0.8	26.04	7.16	0.92	P	0.99	disease_causing	0.78	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12797	12797	T	A	MI.20234	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	461	154	L	H	cTc/cAc	-0.96	0	0	probably_damaging	1	neutral	0.43	neutral	3.89	deleterious	-7.95	deleterious	-6.89	high_impact	5.24	0.24	damaging	0.29	neutral	4.09	23.70	deleterious	0.11	0.4	1	disease	0.82	disease	0.78	disease	0.88	disease	8	1	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.17	medium_impact	3.58	high_impact	0.42	0.8	26.04	7.16	0.85	P	0.97	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12799	12799	A	G	MI.20235	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	463	155	I	V	Atc/Gtc	-8.76	0	0	probably_damaging	1	neutral	0.25	neutral	4.35	neutral	-1.45	neutral	-0.98	medium_impact	2.35	0.41	damaging	0.1	damaging	3.03	22.30	deleterious	0.4	0.5	0.51	disease	0.47	neutral	0.63	disease	0.46	neutral	1	1	deleterious	0.13	neutral	1	deleterious	0.65	deleterious	-3.6	low_impact	-0.03	medium_impact	0.94	medium_impact	0.57	0.8	26.7	7.23	0.48	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12799	12799	A	T	MI.20236	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	463	155	I	F	Atc/Ttc	-8.76	0	0	probably_damaging	1	neutral	0.61	neutral	4.17	deleterious	-5.58	deleterious	-3.92	high_impact	5.04	0.35	damaging	0.07	damaging	3.74	23.30	deleterious	0.17	0.45	0.91	disease	0.82	disease	0.75	disease	0.81	disease	6	1	deleterious	0.31	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.34	medium_impact	3.4	high_impact	0.56	0.8	26.7	7.23	0.62	P	0.96	polymorphism	0.7	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12799	12799	A	C	MI.20237	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	463	155	I	L	Atc/Ctc	-8.76	0	0	probably_damaging	1	neutral	1	neutral	4.29	deleterious	-3.11	neutral	-1.96	high_impact	4.14	0.36	damaging	0.1	damaging	3.74	23.30	deleterious	0.23	0.45	0.47	neutral	0.69	disease	0.62	disease	0.66	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.69	deleterious	-3.6	low_impact	1.89	high_impact	2.58	high_impact	0.56	0.8	26.7	7.23	0.47	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12800	12800	T	A	MI.20238	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	464	155	I	N	aTc/aAc	8.44	1	0	probably_damaging	1	neutral	0.21	neutral	4.18	deleterious	-6.74	deleterious	-6.86	high_impact	5.04	0.34	damaging	0.1	damaging	4.38	24.10	deleterious	0.12	0.4	0.96	disease	0.86	disease	0.74	disease	0.83	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.09	medium_impact	3.4	high_impact	0.45	0.8	26.7	7.23	0.72	P	0.99	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12800	12800	T	G	MI.20239	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	464	155	I	S	aTc/aGc	8.44	1	0	probably_damaging	1	neutral	0.55	neutral	4.19	deleterious	-4.94	deleterious	-5.88	high_impact	5.04	0.43	damaging	0.12	damaging	4.24	23.90	deleterious	0.14	0.4	0.62	disease	0.84	disease	0.71	disease	0.75	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.28	medium_impact	3.4	high_impact	0.43	0.8	26.7	7.23	0.74	P	0.96	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5971	5971	G	A	MI.2024	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	68	23	G	D	gGc/gAc	7.53	1	0	possibly_damaging	0.88	deleterious	0	neutral	2.65	deleterious	-5.36	deleterious	-3.13	high_impact	4.73	0.49	damaging	0.26	damaging	3.63	23.20	deleterious	0.13	0.55	0.53	disease	0.92	disease	0.7	disease	0.8	disease	6	1	deleterious	0.06	neutral	5	deleterious	0.81	deleterious	-1.57	low_impact	-1.48	low_impact	3.27	high_impact	0.48	0.9	3.31	7.62	0.67	P	0.21	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12800	12800	T	C	MI.20240	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	464	155	I	T	aTc/aCc	8.44	1	0	probably_damaging	1	neutral	0.21	neutral	4.24	deleterious	-4.51	deleterious	-4.9	high_impact	5.04	0.39	damaging	0.09	damaging	3.38	22.90	deleterious	0.26	0.45	0.86	disease	0.72	disease	0.71	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	-0.09	medium_impact	3.4	high_impact	0.48	0.8	26.7	7.23	0.76	P	0.96	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12801	12801	C	G	MI.20241	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	465	155	I	M	atC/atG	5.69	1	0	probably_damaging	1	neutral	0.5	neutral	4.19	deleterious	-5.11	deleterious	-2.92	high_impact	5.04	0.45	damaging	0.14	damaging	3.29	22.80	deleterious	0.28	0.45	0.91	disease	0.66	disease	0.72	disease	0.74	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.23	medium_impact	3.4	high_impact	0.59	0.8	26.7	7.23	0.73	P	0.76	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12801	12801	C	A	MI.20242	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	465	155	I	M	atC/atA	5.69	1	0	probably_damaging	1	neutral	0.5	neutral	4.19	deleterious	-5.11	deleterious	-2.92	high_impact	5.04	0.45	damaging	0.14	damaging	3.72	23.30	deleterious	0.28	0.45	0.91	disease	0.66	disease	0.72	disease	0.74	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.23	medium_impact	3.4	high_impact	0.59	0.8	26.7	7.23	0.74	P	0.76	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12802	12802	A	G	MI.20243	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	466	156	S	G	Agt/Ggt	-4.17	0	0	benign	0.03	neutral	0.43	neutral	4.7	neutral	2.51	neutral	4.43	neutral_impact	-1.15	0.82	neutral	0.98	neutral	-1.14	0.01	neutral	0.53	0.6	0.46	neutral	0.11	neutral	0.32	neutral	0.25	neutral	5	0.55	neutral	0.7	deleterious	-6	neutral	0.13	neutral	0.69	medium_impact	0.17	medium_impact	-2.25	low_impact	0.78	0.85	7.79	11.3	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12802	12802	A	T	MI.20244	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	466	156	S	C	Agt/Tgt	-4.17	0	0	probably_damaging	0.98	neutral	0.17	neutral	4.46	deleterious	-3.24	deleterious	-3.25	medium_impact	3.43	0.59	damaging	0.39	neutral	3.23	22.80	deleterious	0.29	0.45	0.91	disease	0.87	disease	0.59	disease	0.85	disease	7	0.99	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-2.35	low_impact	-0.15	medium_impact	1.93	medium_impact	0.80	0.85	7.79	11.3	0.33	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12802	12802	A	C	MI.20245	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	466	156	S	R	Agt/Cgt	-4.17	0	0	probably_damaging	0.93	neutral	0.33	neutral	4.48	neutral	-2.2	neutral	-2.37	medium_impact	3.43	0.66	neutral	0.54	neutral	3.48	23.10	deleterious	0.25	0.45	0.8	disease	0.94	disease	0.72	disease	0.87	disease	7	0.94	neutral	0.2	neutral	1	deleterious	0.73	deleterious	-1.81	low_impact	0.06	medium_impact	1.93	medium_impact	0.87	0.9	7.79	11.3	0.33	N	0.67	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12803	12803	G	A	MI.20246	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	467	156	S	N	aGt/aAt	1.1	0.86	0	possibly_damaging	0.72	neutral	0.3	neutral	4.5	neutral	-1.47	neutral	-0.43	neutral_impact	0.47	0.73	neutral	0.8	neutral	1.79	14.95	neutral	0.69	0.75	0.74	disease	0.78	disease	0.55	disease	0.59	disease	2	0.78	neutral	0.29	neutral	-3	neutral	0.47	deleterious	-1.14	low_impact	0.03	medium_impact	-0.77	medium_impact	0.71	0.85	7.79	11.3	0.32	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12803	12803	G	T	MI.20247	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	467	156	S	I	aGt/aTt	1.1	0.86	0	probably_damaging	0.95	neutral	0.49	neutral	4.53	neutral	-0.42	deleterious	-4.23	medium_impact	2.54	0.6	neutral	0.57	neutral	3.96	23.60	deleterious	0.43	0.55	0.62	disease	0.93	disease	0.61	disease	0.79	disease	6	0.94	neutral	0.27	neutral	1	deleterious	0.78	deleterious	-1.96	low_impact	0.22	medium_impact	1.12	medium_impact	0.85	0.9	7.79	11.3	0.28	N	0.85	polymorphism	0.97	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12803	12803	G	C	MI.20248	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	467	156	S	T	aGt/aCt	1.1	0.86	0	possibly_damaging	0.78	neutral	0.43	neutral	4.53	neutral	-0.78	neutral	-2.11	medium_impact	3.43	0.61	neutral	0.63	neutral	1.86	15.33	deleterious	0.56	0.6	0.71	disease	0.65	disease	0.6	disease	0.71	disease	4	0.78	neutral	0.33	neutral	0	NA	0.50	deleterious	-1.27	low_impact	0.17	medium_impact	1.93	medium_impact	0.83	0.9	7.79	11.3	0.35	N	0.51	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12805	12805	T	G	MI.20249	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	469	157	W	G	Tga/Gga	-6.01	0	0	probably_damaging	1	neutral	0.47	neutral	4.66	neutral	-1	deleterious	-12.83	medium_impact	2.56	0.55	damaging	0.04	damaging	3.85	23.40	deleterious	0.36	0.5	0.82	disease	0.91	disease	0.81	disease	0.85	disease	7	1	deleterious	0.24	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.2	medium_impact	1.14	medium_impact	0.37	0.8	29.19	7.25	0.32	N	0.97	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5973	5973	G	T	MI.2025	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	70	24	A	S	Gca/Tca	-11.44	0	0	benign	0.18	neutral	0.13	neutral	2.76	neutral	-0.84	neutral	-0.77	low_impact	1.64	0.58	damaging	0.66	neutral	0.65	8.50	deleterious	0.46	0.55	0.39	neutral	0.56	disease	0.2	neutral	0.46	neutral	1	0.85	neutral	0.48	deleterious	-6	neutral	0.23	neutral	-0.14	medium_impact	-0.27	medium_impact	0.42	medium_impact	0.77	0.9	3.12	8.36	0.57	P	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12805	12805	T	C	MI.20250	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	469	157	W	R	Tga/Cga	-6.01	0	0	probably_damaging	1	neutral	0.43	neutral	4.66	neutral	-0.88	deleterious	-13.81	medium_impact	2.42	0.57	damaging	0.04	damaging	3.52	23.10	deleterious	0.54	0.6	0.83	disease	0.94	disease	0.85	disease	0.89	disease	8	1	deleterious	0.22	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	0.17	medium_impact	1.01	medium_impact	0.36	0.8	29.19	7.25	0.32	N	0.97	disease_causing	0.97	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12806	12806	G	T	MI.20251	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	470	157	W	L	tGa/tTa	5.69	1	0	probably_damaging	1	neutral	0.95	neutral	4.78	neutral	1.51	deleterious	-12.83	medium_impact	2.38	0.53	damaging	0.02	damaging	4.21	23.90	deleterious	0.45	0.55	0.42	neutral	0.91	disease	0.8	disease	0.81	disease	6	1	deleterious	0.48	deleterious	1	deleterious	0.79	deleterious	-3.6	low_impact	0.94	medium_impact	0.97	medium_impact	0.35	0.8	29.19	7.25	0.47	N	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12806	12806	G	C	MI.20252	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	470	157	W	S	tGa/tCa	5.69	1	0	probably_damaging	1	neutral	0.47	neutral	4.67	neutral	-0.44	deleterious	-13.81	high_impact	3.65	0.52	damaging	0.04	damaging	3.97	23.60	deleterious	0.37	0.5	0.71	disease	0.93	disease	0.8	disease	0.86	disease	7	1	deleterious	0.24	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.2	medium_impact	2.13	high_impact	0.31	0.8	29.19	7.25	0.52	N	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12807	12807	A	C	MI.20253	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	471	157	W	C	tgA/tgC	9.13	1	0	probably_damaging	1	neutral	0.17	neutral	4.64	neutral	-2.48	deleterious	-12.83	medium_impact	3.19	0.51	damaging	0.03	damaging	4.08	23.70	deleterious	0.35	0.5	0.89	disease	0.93	disease	0.83	disease	0.89	disease	8	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.15	medium_impact	1.71	medium_impact	0.33	0.8	29.19	7.25	0.52	P	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12807	12807	A	T	MI.20254	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	471	157	W	C	tgA/tgT	9.13	1	0	probably_damaging	1	neutral	0.17	neutral	4.64	neutral	-2.48	deleterious	-12.83	medium_impact	3.19	0.51	damaging	0.03	damaging	4.05	23.70	deleterious	0.35	0.5	0.89	disease	0.93	disease	0.83	disease	0.89	disease	8	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.15	medium_impact	1.71	medium_impact	0.33	0.8	29.19	7.25	0.52	P	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12808	12808	T	G	MI.20255	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	472	158	W	G	Tga/Gga	1.56	1	0	probably_damaging	1	neutral	0.37	neutral	4.48	neutral	-2.56	deleterious	-12.8	high_impact	3.71	0.52	damaging	0.04	damaging	3.85	23.40	deleterious	0.31	0.45	0.77	disease	0.9	disease	0.85	disease	0.85	disease	7	1	deleterious	0.19	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.11	medium_impact	2.19	high_impact	0.28	0.8	26.87	7.26	0.47	N	0.97	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12808	12808	T	C	MI.20256	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	472	158	W	R	Tga/Cga	1.56	1	0	probably_damaging	1	neutral	0.37	neutral	4.46	neutral	-2.72	deleterious	-13.79	high_impact	3.6	0.54	damaging	0.03	damaging	3.53	23.10	deleterious	0.4	0.5	0.78	disease	0.94	disease	0.87	disease	0.88	disease	8	1	deleterious	0.19	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.11	medium_impact	2.09	high_impact	0.26	0.8	26.87	7.26	0.44	N	0.97	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12809	12809	G	T	MI.20257	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	473	158	W	L	tGa/tTa	7.3	1	0	probably_damaging	1	neutral	0.75	neutral	4.51	deleterious	-3.38	deleterious	-12.8	high_impact	4.05	0.51	damaging	0.03	damaging	4.22	23.90	deleterious	0.25	0.45	0.77	disease	0.9	disease	0.83	disease	0.84	disease	7	1	deleterious	0.38	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.5	medium_impact	2.5	high_impact	0.24	0.8	26.87	7.26	0.57	P	0.97	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12809	12809	G	C	MI.20258	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	473	158	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.48	neutral	4.46	neutral	-2.89	deleterious	-13.79	medium_impact	3.18	0.53	damaging	0.04	damaging	3.98	23.60	deleterious	0.27	0.45	0.65	disease	0.93	disease	0.83	disease	0.85	disease	7	1	deleterious	0.24	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.21	medium_impact	1.7	medium_impact	0.24	0.8	26.87	7.26	0.48	N	0.95	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12810	12810	A	T	MI.20259	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	474	158	W	C	tgA/tgT	7.3	1	0.02	probably_damaging	1	neutral	0.18	neutral	4.43	deleterious	-6.77	deleterious	-12.8	high_impact	4.75	0.51	damaging	0.03	damaging	4.06	23.70	deleterious	0.3	0.45	0.97	disease	0.92	disease	0.86	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.13	medium_impact	3.14	high_impact	0.20	0.8	26.87	7.26	0.54	P	0.98	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5973	5973	G	C	MI.2026	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	70	24	A	P	Gca/Cca	-11.44	0	0	possibly_damaging	0.53	neutral	0.05	neutral	2.73	neutral	-1.87	neutral	-1.53	medium_impact	3.31	0.53	damaging	0.43	neutral	3.36	22.90	deleterious	0.15	0.55	0.63	disease	0.89	disease	0.58	disease	0.79	disease	6	0.95	neutral	0.26	neutral	0	NA	0.71	deleterious	-0.81	medium_impact	-0.52	medium_impact	1.96	medium_impact	0.81	0.9	3.12	8.36	0.4	N	0.85	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12810	12810	A	C	MI.20260	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	474	158	W	C	tgA/tgC	7.3	1	0.02	probably_damaging	1	neutral	0.18	neutral	4.43	deleterious	-6.77	deleterious	-12.8	high_impact	4.75	0.51	damaging	0.03	damaging	3.99	23.60	deleterious	0.3	0.45	0.97	disease	0.92	disease	0.86	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.13	medium_impact	3.14	high_impact	0.20	0.8	26.87	7.26	0.54	P	0.98	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12811	12811	T	G	MI.20261	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	475	159	Y	D	Tac/Gac	-0.27	0	0.1	possibly_damaging	0.75	neutral	0.22	neutral	4.66	neutral	-2.49	deleterious	-7.26	medium_impact	3.46	0.75	neutral	0.37	neutral	3.54	23.10	deleterious	0.41	0.5	0.73	disease	0.91	disease	0.63	disease	0.75	disease	5	0.85	neutral	0.24	neutral	0	NA	0.56	deleterious	-1.2	low_impact	-0.07	medium_impact	1.96	medium_impact	0.37	0.8	6.97	11.79	0.36	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12811	12811	T	A	MI.20262	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	475	159	Y	N	Tac/Aac	-0.27	0	0.1	possibly_damaging	0.48	neutral	0.31	neutral	4.7	neutral	-2.14	deleterious	-6.07	low_impact	1.84	0.79	neutral	0.69	neutral	2.25	17.87	deleterious	0.46	0.55	0.65	disease	0.88	disease	0.58	disease	0.68	disease	4	0.66	neutral	0.42	neutral	-3	neutral	0.43	deleterious	-0.71	medium_impact	0.04	medium_impact	0.48	medium_impact	0.35	0.8	6.97	11.79	0.28	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12811	12811	T	C	MI.20263	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	475	159	Y	H	Tac/Cac	-0.27	0	0.1	benign	0.01	neutral	0.52	neutral	4.62	neutral	-1.53	neutral	-1.81	low_impact	0.92	0.83	neutral	0.97	neutral	0.04	3.02	deleterious	0.62	0.65	0.41	neutral	0.43	neutral	0.33	neutral	0.45	neutral	1	0.46	neutral	0.76	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.25	medium_impact	-0.36	medium_impact	0.40	0.8	6.97	11.79	0.32	N	0.98	disease_causing_automatic	0	0.03	rs199974018	Uncertain_significance	Leber's_optic_atrophy|not_specified	76418	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:CN169374	.	.	.	.	T12811C	Possible LHON factor	+	-	Reported	4	P	P	P	neutral
chrM	12812	12812	A	T	MI.20264	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	476	159	Y	F	tAc/tTc	-0.96	0	0	possibly_damaging	0.64	neutral	0.81	neutral	4.65	neutral	-0.99	deleterious	-2.92	neutral_impact	0.32	0.82	neutral	0.98	neutral	0.41	6.70	deleterious	0.4	0.5	0.55	disease	0.66	disease	0.35	neutral	0.49	neutral	0	0.57	neutral	0.59	deleterious	-3	neutral	0.53	deleterious	-0.98	medium_impact	0.58	medium_impact	-0.91	medium_impact	0.32	0.8	6.97	11.79	0.23	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12812	12812	A	G	MI.20265	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	476	159	Y	C	tAc/tGc	-0.96	0	0	benign	0.06	neutral	0.17	neutral	4.61	deleterious	-6.08	deleterious	-6.93	medium_impact	2.96	0.76	neutral	0.43	neutral	1.46	13.10	neutral	0.32	0.5	0.95	disease	0.91	disease	0.55	disease	0.83	disease	7	0.82	neutral	0.56	deleterious	-3	neutral	0.30	neutral	0.39	medium_impact	-0.15	medium_impact	1.5	medium_impact	0.13	0.8	6.97	11.79	0.33	N	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12812	12812	A	C	MI.20266	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	476	159	Y	S	tAc/tCc	-0.96	0	0	possibly_damaging	0.56	neutral	0.5	neutral	4.72	neutral	-1.86	deleterious	-6.43	low_impact	1.16	0.85	neutral	0.8	neutral	1.82	15.11	deleterious	0.32	0.5	0.53	disease	0.78	disease	0.44	neutral	0.53	disease	1	0.55	neutral	0.47	deleterious	-3	neutral	0.44	deleterious	-0.85	medium_impact	0.23	medium_impact	-0.14	medium_impact	0.41	0.8	6.97	11.79	0.27	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12814	12814	G	C	MI.20267	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	478	160	A	P	Gcc/Ccc	-9.68	0	0	probably_damaging	0.95	neutral	0.2	neutral	4.59	neutral	-1.98	neutral	-2.15	low_impact	1.81	0.64	neutral	0.35	neutral	3.81	23.40	deleterious	0.33	0.5	0.82	disease	0.93	disease	0.57	disease	0.8	disease	6	0.97	neutral	0.13	neutral	-2	neutral	0.88	deleterious	-1.96	low_impact	-0.1	medium_impact	0.45	medium_impact	0.77	0.85	17.08	18.65	0.25	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12814	12814	G	A	MI.20268	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	478	160	A	T	Gcc/Acc	-9.68	0	0	possibly_damaging	0.73	neutral	0.39	neutral	4.68	neutral	0.79	neutral	-1.89	neutral_impact	-0.45	0.72	neutral	0.8	neutral	4.28	24.00	deleterious	0.58	0.65	0.4	neutral	0.45	neutral	0.49	neutral	0.48	neutral	0	0.74	neutral	0.33	neutral	-3	neutral	0.69	deleterious	-1.16	low_impact	0.13	medium_impact	-1.61	low_impact	0.72	0.85	17.08	18.65	0.33	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12814	12814	G	T	MI.20269	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	478	160	A	S	Gcc/Tcc	-9.68	0	0	benign	0.18	neutral	0.41	neutral	4.66	neutral	0.35	neutral	0.13	neutral_impact	-0.03	0.83	neutral	0.88	neutral	2.53	19.64	deleterious	0.55	0.6	0.45	neutral	0.54	disease	0.31	neutral	0.47	neutral	1	0.51	neutral	0.62	deleterious	-6	neutral	0.73	deleterious	-0.12	medium_impact	0.15	medium_impact	-1.23	low_impact	0.75	0.85	17.08	18.65	0.34	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5973	5973	G	A	MI.2027	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	70	24	A	T	Gca/Aca	-11.44	0	0	benign	0.01	neutral	0.16	neutral	2.79	neutral	-0.28	neutral	-0.74	low_impact	1.54	0.6	neutral	0.8	neutral	0.89	10.02	neutral	0.44	0.55	0.33	neutral	0.48	neutral	0.22	neutral	0.46	neutral	1	0.84	neutral	0.58	deleterious	-6	neutral	0.16	neutral	1.12	medium_impact	-0.21	medium_impact	0.32	medium_impact	0.66	0.9	3.12	8.36	0.58	P	0.20	polymorphism	1	0.02	.	.	.	.	.	pancreatic cancer cell line	.	.	0.59	G5973A	Prostate Cancer	+	-	Reported	1	.	P	P	damaging
chrM	12815	12815	C	T	MI.20270	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	479	160	A	V	gCc/gTc	2.25	0.6	0	possibly_damaging	0.9	neutral	0.5	neutral	4.61	neutral	-1.98	deleterious	-3.02	medium_impact	2.16	0.9	neutral	0.69	neutral	4.47	24.20	deleterious	0.58	0.65	0.79	disease	0.74	disease	0.55	disease	0.73	disease	5	0.89	neutral	0.3	neutral	0	NA	0.78	deleterious	-1.65	low_impact	0.23	medium_impact	0.77	medium_impact	0.60	0.8	17.08	18.65	0.36	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12815	12815	C	G	MI.20271	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	479	160	A	G	gCc/gGc	2.25	0.6	0	benign	0.04	neutral	0.37	neutral	4.64	neutral	1.26	neutral	4.61	neutral_impact	-0.35	0.73	neutral	0.95	neutral	1.26	12.06	neutral	0.6	0.65	0.36	neutral	0.12	neutral	0.24	neutral	0.28	neutral	4	0.6	neutral	0.67	deleterious	-6	neutral	0.67	deleterious	0.57	medium_impact	0.11	medium_impact	-1.52	low_impact	0.80	0.85	17.08	18.65	0.39	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12815	12815	C	A	MI.20272	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	479	160	A	D	gCc/gAc	2.25	0.6	0	possibly_damaging	0.87	neutral	0.21	neutral	4.64	neutral	0.21	neutral	-1.28	low_impact	1.1	0.69	neutral	0.43	neutral	4.48	24.20	deleterious	0.44	0.55	0.52	disease	0.9	disease	0.64	disease	0.81	disease	6	0.92	neutral	0.17	neutral	-3	neutral	0.82	deleterious	-1.53	low_impact	-0.09	medium_impact	-0.2	medium_impact	0.61	0.8	17.08	18.65	0.31	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12817	12817	C	T	MI.20273	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	481	161	R	W	Cga/Tga	-7.61	0	0	probably_damaging	1	neutral	0.22	neutral	4.52	deleterious	-6.71	deleterious	-7.89	high_impact	4.63	0.43	damaging	0.01	damaging	5.21	25.50	deleterious	0.42	0.55	0.83	disease	0.91	disease	0.77	disease	0.8	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.07	medium_impact	3.03	high_impact	0.88	0.9	26.53	7.17	0.49	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12817	12817	C	G	MI.20274	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	481	161	R	G	Cga/Gga	-7.61	0	0	probably_damaging	1	neutral	0.38	neutral	4.54	neutral	-2.6	deleterious	-6.91	high_impact	3.54	0.42	damaging	0.03	damaging	4.23	23.90	deleterious	0.35	0.5	0.75	disease	0.83	disease	0.77	disease	0.77	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.12	medium_impact	2.03	high_impact	0.49	0.8	26.53	7.17	0.41	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12818	12818	G	T	MI.20275	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	482	161	R	L	cGa/cTa	2.25	0.96	0	probably_damaging	1	neutral	0.68	neutral	4.55	deleterious	-4.04	deleterious	-6.91	high_impact	3.54	0.41	damaging	0.01	damaging	4.35	24.10	deleterious	0.34	0.5	0.59	disease	0.93	disease	0.75	disease	0.83	disease	6	1	deleterious	0.34	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.41	medium_impact	2.03	high_impact	0.41	0.8	26.53	7.17	0.58	P	1.00	disease_causing	0.97	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12818	12818	G	C	MI.20276	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	482	161	R	P	cGa/cCa	2.25	0.96	0	probably_damaging	1	neutral	0.21	neutral	4.53	deleterious	-3.37	deleterious	-6.91	high_impact	4.29	0.36	damaging	0.02	damaging	4.24	23.90	deleterious	0.29	0.45	0.79	disease	0.9	disease	0.77	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.09	medium_impact	2.72	high_impact	0.40	0.8	26.53	7.17	0.68	P	0.99	disease_causing	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12818	12818	G	A	MI.20277	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	482	161	R	Q	cGa/cAa	2.25	0.96	0	probably_damaging	1	neutral	0.3	neutral	4.65	neutral	-2.29	deleterious	-3.95	medium_impact	2.9	0.44	damaging	0.02	damaging	4.51	24.30	deleterious	0.5	0.6	0.65	disease	0.83	disease	0.76	disease	0.78	disease	6	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.03	medium_impact	1.45	medium_impact	0.89	0.9	26.53	7.17	0.55	P	0.99	disease_causing	0.8	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12820	12820	G	T	MI.20278	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	484	162	A	S	Gca/Tca	-1.65	0	0.01	benign	0.02	neutral	0.44	neutral	4.67	neutral	-1.07	neutral	0.46	neutral_impact	-0.14	0.81	neutral	0.93	neutral	0.43	6.89	deleterious	0.66	0.7	0.65	disease	0.5	neutral	0.18	neutral	0.48	neutral	0	0.54	neutral	0.71	deleterious	-6	neutral	0.22	neutral	0.86	medium_impact	0.18	medium_impact	-1.33	low_impact	0.94	0.95	4.64	9.64	0.4	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12820	12820	G	A	MI.20279	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	484	162	A	T	Gca/Aca	-1.65	0	0.01	benign	0	neutral	0.41	neutral	4.61	neutral	-1.57	neutral	2.21	neutral_impact	0.43	0.88	neutral	0.95	neutral	-0.38	0.44	neutral	0.61	0.65	0.59	disease	0.25	neutral	0.16	neutral	0.55	disease	1	0.59	neutral	0.71	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	0.15	medium_impact	-0.81	medium_impact	0.83	0.85	4.64	9.64	0.48	N	0.03	polymorphism	1	0.01	rs200567053	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5974	5974	C	G	MI.2028	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	71	24	A	G	gCa/gGa	3.6	1	0	benign	0.07	neutral	0.1	neutral	2.73	neutral	-2.12	neutral	-1.53	medium_impact	2.03	0.59	damaging	0.6	neutral	1.82	15.09	deleterious	0.27	0.55	0.4	neutral	0.58	disease	0.31	neutral	0.49	neutral	0	0.89	neutral	0.52	deleterious	-3	neutral	0.20	neutral	0.3	medium_impact	-0.34	medium_impact	0.78	medium_impact	0.68	0.9	3.12	8.36	0.58	P	0.56	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12820	12820	G	C	MI.20280	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	484	162	A	P	Gca/Cca	-1.65	0	0.01	benign	0.1	neutral	0.2	neutral	4.69	neutral	-0.1	neutral	-1.56	neutral_impact	0.34	0.77	neutral	0.57	neutral	1.92	15.71	deleterious	0.42	0.55	0.52	disease	0.84	disease	0.37	neutral	0.54	disease	1	0.78	neutral	0.55	deleterious	-6	neutral	0.30	neutral	0.16	medium_impact	-0.1	medium_impact	-0.89	medium_impact	0.91	0.95	4.64	9.64	0.29	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12821	12821	C	T	MI.20281	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	485	162	A	V	gCa/gTa	-2.34	0	0	benign	0.03	neutral	0.5	neutral	4.61	neutral	-2.12	neutral	-1.25	low_impact	1.24	0.76	neutral	0.58	neutral	2.49	19.40	deleterious	0.57	0.65	0.82	disease	0.65	disease	0.46	neutral	0.6	disease	2	0.46	neutral	0.74	deleterious	-6	neutral	0.26	neutral	0.69	medium_impact	0.23	medium_impact	-0.07	medium_impact	0.74	0.85	4.64	9.64	0.23	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12821	12821	C	G	MI.20282	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	485	162	A	G	gCa/gGa	-2.34	0	0	benign	0.05	neutral	0.39	neutral	4.57	neutral	-1.34	neutral	-2.16	low_impact	1.75	0.73	neutral	0.56	neutral	2.01	16.26	deleterious	0.61	0.65	0.81	disease	0.7	disease	0.44	neutral	0.59	disease	2	0.58	neutral	0.67	deleterious	-6	neutral	0.27	neutral	0.47	medium_impact	0.13	medium_impact	0.4	medium_impact	0.93	0.95	4.64	9.64	0.26	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12821	12821	C	A	MI.20283	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	485	162	A	E	gCa/gAa	-2.34	0	0	benign	0	neutral	0.28	neutral	4.68	neutral	-0.48	neutral	-1.68	neutral_impact	0.57	0.76	neutral	0.5	neutral	2.51	19.56	deleterious	0.49	0.55	0.49	neutral	0.82	disease	0.51	disease	0.54	disease	1	0.72	neutral	0.64	deleterious	-6	neutral	0.25	neutral	2.1	high_impact	0.01	medium_impact	-0.68	medium_impact	0.80	0.85	4.64	9.64	0.31	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12823	12823	G	C	MI.20284	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	487	163	D	H	Gat/Cat	-0.04	0.57	0	probably_damaging	0.99	neutral	0.54	neutral	4.57	neutral	-2.8	deleterious	-6.5	medium_impact	3.11	0.71	neutral	0.24	damaging	3.68	23.30	deleterious	0.6	0.65	0.81	disease	0.79	disease	0.68	disease	0.73	disease	5	0.99	deleterious	0.28	neutral	1	deleterious	0.78	deleterious	-2.64	low_impact	0.27	medium_impact	1.64	medium_impact	0.44	0.8	4.98	7.98	0.24	N	0.99	disease_causing	0.72	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12823	12823	G	A	MI.20285	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	487	163	D	N	Gat/Aat	-0.04	0.57	0	probably_damaging	0.94	neutral	0.34	neutral	4.64	neutral	-0.64	deleterious	-4.66	neutral_impact	0.78	0.76	neutral	0.54	neutral	3.98	23.60	deleterious	0.75	0.8	0.54	disease	0.74	disease	0.38	neutral	0.52	disease	0	0.94	neutral	0.2	neutral	-2	neutral	0.68	deleterious	-1.88	low_impact	0.07	medium_impact	-0.49	medium_impact	0.76	0.85	4.98	7.98	0.23	N	0.98	polymorphism	0.67	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12823	12823	G	T	MI.20286	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	487	163	D	Y	Gat/Tat	-0.04	0.57	0	probably_damaging	0.99	neutral	1	neutral	4.56	deleterious	-3.59	deleterious	-8.48	medium_impact	2.62	0.69	neutral	0.51	neutral	3.93	23.50	deleterious	0.45	0.55	0.88	disease	0.92	disease	0.68	disease	0.8	disease	6	0.99	deleterious	0.51	deleterious	1	deleterious	0.83	deleterious	-2.64	low_impact	1.89	high_impact	1.19	medium_impact	0.20	0.8	4.98	7.98	0.27	N	0.99	disease_causing	0.84	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12824	12824	A	T	MI.20287	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	488	163	D	V	gAt/gTt	4.31	1	0	probably_damaging	0.98	neutral	0.52	neutral	4.57	neutral	-2.38	deleterious	-8.48	medium_impact	2.31	0.69	neutral	0.33	neutral	3.65	23.20	deleterious	0.33	0.5	0.41	neutral	0.88	disease	0.63	disease	0.73	disease	5	0.98	neutral	0.27	neutral	1	deleterious	0.72	deleterious	-2.35	low_impact	0.25	medium_impact	0.91	medium_impact	0.23	0.8	4.98	7.98	0.39	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12824	12824	A	G	MI.20288	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	488	163	D	G	gAt/gGt	4.31	1	0	probably_damaging	0.95	neutral	0.35	neutral	4.57	neutral	-1.61	deleterious	-6.65	medium_impact	2.12	0.71	neutral	0.45	neutral	3.75	23.30	deleterious	0.44	0.55	0.68	disease	0.86	disease	0.65	disease	0.71	disease	4	0.96	neutral	0.2	neutral	1	deleterious	0.72	deleterious	-1.96	low_impact	0.08	medium_impact	0.73	medium_impact	0.40	0.8	4.98	7.98	0.42	N	0.98	disease_causing	0.83	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12824	12824	A	C	MI.20289	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	488	163	D	A	gAt/gCt	4.31	1	0	probably_damaging	0.91	neutral	0.55	neutral	4.63	neutral	-0.38	deleterious	-7.5	low_impact	1.15	0.73	neutral	0.42	neutral	3.40	23.00	deleterious	0.32	0.5	0.46	neutral	0.76	disease	0.63	disease	0.63	disease	3	0.9	neutral	0.32	neutral	-2	neutral	0.65	deleterious	-1.7	low_impact	0.28	medium_impact	-0.15	medium_impact	0.43	0.8	4.98	7.98	0.33	N	0.94	disease_causing	0.78	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5974	5974	C	A	MI.2029	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	71	24	A	E	gCa/gAa	3.6	1	0	possibly_damaging	0.56	neutral	0.07	neutral	2.72	neutral	-2.63	neutral	-1.5	medium_impact	3.31	0.58	damaging	0.48	neutral	3.94	23.50	deleterious	0.2	0.55	0.2	neutral	0.85	disease	0.49	neutral	0.76	disease	5	0.93	neutral	0.26	neutral	0	NA	0.49	deleterious	-0.86	medium_impact	-0.43	medium_impact	1.96	medium_impact	0.72	0.9	3.12	8.36	0.56	P	0.76	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12825	12825	T	A	MI.20290	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	489	163	D	E	gaT/gaA	8.44	1	0	benign	0.15	neutral	0.33	neutral	4.74	neutral	0.37	deleterious	-3.42	neutral_impact	0.28	0.84	neutral	0.77	neutral	2.08	16.70	deleterious	0.52	0.6	0.39	neutral	0.57	disease	0.34	neutral	0.45	neutral	1	0.61	neutral	0.59	deleterious	-6	neutral	0.20	neutral	-0.03	medium_impact	0.06	medium_impact	-0.95	medium_impact	0.51	0.8	4.98	7.98	0.51	N	0.91	polymorphism	0.71	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12825	12825	T	G	MI.20291	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	489	163	D	E	gaT/gaG	8.44	1	0	benign	0.15	neutral	0.33	neutral	4.74	neutral	0.37	deleterious	-3.42	neutral_impact	0.28	0.84	neutral	0.77	neutral	1.94	15.85	deleterious	0.52	0.6	0.39	neutral	0.57	disease	0.34	neutral	0.45	neutral	1	0.61	neutral	0.59	deleterious	-6	neutral	0.20	neutral	-0.03	medium_impact	0.06	medium_impact	-0.95	medium_impact	0.51	0.8	4.98	7.98	0.51	N	0.91	polymorphism	0.71	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12826	12826	G	T	MI.20292	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	490	164	A	S	Gcc/Tcc	-5.32	0	0	probably_damaging	1	neutral	0.41	neutral	4.69	neutral	-0.93	deleterious	-2.86	low_impact	1.47	0.42	damaging	0.19	damaging	3.70	23.30	deleterious	0.56	0.6	0.53	disease	0.79	disease	0.63	disease	0.62	disease	2	1	deleterious	0.21	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.15	medium_impact	0.14	medium_impact	0.78	0.85	24.71	7.13	0.38	N	0.98	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12826	12826	G	A	MI.20293	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	490	164	A	T	Gcc/Acc	-5.32	0	0	probably_damaging	1	neutral	0.39	neutral	4.47	deleterious	-3.48	deleterious	-3.72	high_impact	3.53	0.42	damaging	0.14	damaging	4.30	24.00	deleterious	0.48	0.55	0.82	disease	0.78	disease	0.58	disease	0.68	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.13	medium_impact	2.02	high_impact	0.68	0.85	24.71	7.13	0.41	N	0.94	polymorphism	0.96	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12826	12826	G	C	MI.20294	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	490	164	A	P	Gcc/Ccc	-5.32	0	0	probably_damaging	1	neutral	0.2	neutral	4.42	deleterious	-3.37	deleterious	-4.83	high_impact	3.58	0.49	damaging	0.08	damaging	3.85	23.40	deleterious	0.26	0.45	0.84	disease	0.87	disease	0.77	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.1	medium_impact	2.07	high_impact	0.74	0.85	24.71	7.13	0.38	N	0.96	polymorphism	0.88	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12827	12827	C	T	MI.20295	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	491	164	A	V	gCc/gTc	4.08	1	0	probably_damaging	1	neutral	0.49	neutral	4.43	deleterious	-3.03	deleterious	-3.85	medium_impact	3.19	0.4	damaging	0.05	damaging	4.48	24.20	deleterious	0.53	0.6	0.57	disease	0.81	disease	0.65	disease	0.67	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.22	medium_impact	1.71	medium_impact	0.70	0.85	24.71	7.13	0.68	P	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12827	12827	C	G	MI.20296	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	491	164	A	G	gCc/gGc	4.08	1	0	probably_damaging	1	neutral	0.34	neutral	4.45	deleterious	-3.38	deleterious	-3.9	high_impact	4.22	0.47	damaging	0.11	damaging	3.98	23.60	deleterious	0.41	0.5	0.92	disease	0.78	disease	0.66	disease	0.8	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.07	medium_impact	2.65	high_impact	0.73	0.85	24.71	7.13	0.58	P	0.82	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12827	12827	C	A	MI.20297	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	491	164	A	D	gCc/gAc	4.08	1	0	probably_damaging	1	neutral	0.21	neutral	4.45	deleterious	-3.86	deleterious	-5.8	high_impact	3.73	0.6	neutral	0.09	damaging	4.47	24.20	deleterious	0.28	0.45	0.95	disease	0.9	disease	0.78	disease	0.85	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.09	medium_impact	2.2	high_impact	0.50	0.8	24.71	7.13	0.57	P	0.95	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12829	12829	A	T	MI.20298	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	493	165	N	Y	Aac/Tac	-11.28	0	0	probably_damaging	1	neutral	1	neutral	4.61	neutral	-0.86	deleterious	-7.89	medium_impact	2.4	0.63	neutral	0.1	damaging	3.74	23.30	deleterious	0.54	0.6	0.64	disease	0.75	disease	0.68	disease	0.67	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.80	deleterious	-3.6	low_impact	1.89	high_impact	0.99	medium_impact	0.33	0.8	28.36	7.2	0.19	N	0.99	polymorphism	0.94	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12829	12829	A	G	MI.20299	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	493	165	N	D	Aac/Gac	-11.28	0	0	probably_damaging	1	neutral	0.21	neutral	4.58	neutral	-2.59	deleterious	-4.93	medium_impact	3.5	0.72	neutral	0.1	damaging	3.84	23.40	deleterious	0.66	0.7	0.72	disease	0.6	disease	0.7	disease	0.71	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	-0.09	medium_impact	1.99	medium_impact	0.34	0.8	28.36	7.2	0.33	N	0.94	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8621	8621	C	A	MI.203	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	95	32	P	H	cCc/cAc	0.13	0	0	probably_damaging	1	neutral	0.1	neutral	4.4	neutral	0.25	deleterious	-7.25	medium_impact	2.51	0.87	neutral	0.17	damaging	3.89	23.50	deleterious	0.41	0.65	0.76	disease	0.8	disease	0.49	neutral	0.59	disease	2	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.25	medium_impact	1.05	medium_impact	0.50	0.9	29.2	19.38	0.31	N	0.90	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5974	5974	C	T	MI.2030	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	71	24	A	V	gCa/gTa	3.6	1	0	benign	0.11	neutral	0.35	neutral	2.92	neutral	1.1	neutral	-0.06	neutral_impact	0.07	0.6	damaging	0.61	neutral	0.89	10.01	neutral	0.34	0.55	0.2	neutral	0.48	neutral	0.22	neutral	0.44	neutral	1	0.6	neutral	0.62	deleterious	-6	neutral	0.30	neutral	0.1	medium_impact	0.04	medium_impact	-1.03	low_impact	0.76	0.9	3.12	8.36	0.53	P	0.75	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12829	12829	A	C	MI.20300	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	493	165	N	H	Aac/Cac	-11.28	0	0	probably_damaging	1	neutral	0.54	neutral	4.58	neutral	-2.28	deleterious	-4.93	high_impact	3.63	0.69	neutral	0.08	damaging	3.04	22.30	deleterious	0.63	0.65	0.85	disease	0.56	disease	0.73	disease	0.75	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.27	medium_impact	2.11	high_impact	0.39	0.8	28.36	7.2	0.25	N	0.97	polymorphism	0.98	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12830	12830	A	G	MI.20301	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	494	165	N	S	aAc/aGc	5.46	1	0	probably_damaging	1	neutral	0.43	neutral	4.67	neutral	0.37	deleterious	-4.93	low_impact	1.54	0.88	neutral	0.09	damaging	3.12	22.60	deleterious	0.75	0.8	0.45	neutral	0.56	disease	0.63	disease	0.48	neutral	0	1	deleterious	0.22	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.17	medium_impact	0.2	medium_impact	0.22	0.8	28.36	7.2	0.47	N	0.82	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12830	12830	A	C	MI.20302	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	494	165	N	T	aAc/aCc	5.46	1	0	probably_damaging	1	neutral	0.39	neutral	4.68	neutral	0.54	deleterious	-5.92	medium_impact	1.99	0.72	neutral	0.09	damaging	3.43	23.00	deleterious	0.68	0.7	0.54	disease	0.6	disease	0.63	disease	0.57	disease	1	1	deleterious	0.2	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.13	medium_impact	0.62	medium_impact	0.44	0.8	28.36	7.2	0.41	N	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12830	12830	A	T	MI.20303	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	494	165	N	I	aAc/aTc	5.46	1	0	probably_damaging	1	neutral	0.43	neutral	4.73	neutral	1.13	deleterious	-8.88	medium_impact	2.94	0.68	neutral	0.09	damaging	4.05	23.70	deleterious	0.51	0.6	0.74	disease	0.8	disease	0.66	disease	0.61	disease	2	1	deleterious	0.22	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.17	medium_impact	1.48	medium_impact	0.28	0.8	28.36	7.2	0.44	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12831	12831	C	G	MI.20304	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	495	165	N	K	aaC/aaG	5.46	1	0	probably_damaging	1	neutral	0.29	neutral	4.62	neutral	-0.51	deleterious	-5.92	medium_impact	3.29	0.69	neutral	0.09	damaging	3.91	23.50	deleterious	0.67	0.7	0.55	disease	0.65	disease	0.7	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.02	medium_impact	1.8	medium_impact	0.50	0.8	28.36	7.2	0.52	P	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12831	12831	C	A	MI.20305	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	495	165	N	K	aaC/aaA	5.46	1	0	probably_damaging	1	neutral	0.29	neutral	4.62	neutral	-0.51	deleterious	-5.92	medium_impact	3.29	0.69	neutral	0.09	damaging	4.36	24.10	deleterious	0.67	0.7	0.55	disease	0.65	disease	0.7	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.02	medium_impact	1.8	medium_impact	0.50	0.8	28.36	7.2	0.53	P	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12832	12832	A	G	MI.20306	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	496	166	T	A	Aca/Gca	-1.65	0	0	probably_damaging	1	neutral	0.56	neutral	4.66	neutral	0.26	deleterious	-4.93	neutral_impact	0.6	0.72	neutral	0.25	damaging	3.36	22.90	deleterious	0.61	0.65	0.32	neutral	0.38	neutral	0.22	neutral	0.45	neutral	1	1	deleterious	0.28	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.29	medium_impact	-0.66	medium_impact	0.39	0.8	26.87	7.18	0.25	N	0.69	disease_causing	0.54	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12832	12832	A	T	MI.20307	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	496	166	T	S	Aca/Tca	-1.65	0	0	probably_damaging	1	neutral	0.45	neutral	4.69	neutral	0.6	deleterious	-3.95	neutral_impact	-0.12	0.74	neutral	0.29	neutral	3.16	22.60	deleterious	0.5	0.6	0.54	disease	0.45	neutral	0.19	neutral	0.48	neutral	0	1	deleterious	0.23	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.18	medium_impact	-1.31	low_impact	0.59	0.8	26.87	7.18	0.35	N	0.89	polymorphism	0.72	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12832	12832	A	C	MI.20308	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	496	166	T	P	Aca/Cca	-1.65	0	0	probably_damaging	1	neutral	0.22	neutral	4.57	neutral	-2.07	deleterious	-5.92	medium_impact	3.14	0.68	neutral	0.11	damaging	3.43	23.00	deleterious	0.21	0.45	0.81	disease	0.82	disease	0.57	disease	0.71	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.07	medium_impact	1.67	medium_impact	0.46	0.8	26.87	7.18	0.27	N	0.97	disease_causing	0.86	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12833	12833	C	A	MI.20309	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	497	166	T	K	aCa/aAa	5.46	1	0	probably_damaging	1	neutral	0.35	neutral	4.73	neutral	0.95	deleterious	-5.92	neutral_impact	0.62	0.72	neutral	0.17	damaging	4.48	24.20	deleterious	0.36	0.5	0.4	neutral	0.66	disease	0.54	disease	0.48	neutral	0	1	deleterious	0.18	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.08	medium_impact	-0.64	medium_impact	0.67	0.85	26.87	7.18	0.39	N	1.00	disease_causing	0.97	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5976	5976	T	C	MI.2031	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	73	25	W	R	Tga/Cga	-2.88	0	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-2.13	deleterious	-6.6	high_impact	4.77	0.65	neutral	0.04	damaging	3.37	22.90	deleterious	0.36	0.55	0.59	disease	0.92	disease	0.76	disease	0.83	disease	7	1	deleterious	0	deleterious	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.31	high_impact	0.35	0.9	1.95	6.97	0.62	P	0.98	polymorphism	0.74	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12833	12833	C	T	MI.20310	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	497	166	T	M	aCa/aTa	5.46	1	0	probably_damaging	1	neutral	0.23	neutral	4.56	neutral	-2.62	deleterious	-5.92	medium_impact	2.04	0.73	neutral	0.15	damaging	4.03	23.70	deleterious	0.36	0.5	0.86	disease	0.66	disease	0.35	neutral	0.61	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.06	medium_impact	0.66	medium_impact	0.61	0.8	26.87	7.18	0.45	N	0.93	disease_causing	0.95	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12835	12835	G	T	MI.20311	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	499	167	A	S	Gca/Tca	-6.47	0	0	probably_damaging	1	neutral	0.43	neutral	4.36	deleterious	-3.27	deleterious	-2.76	neutral_impact	0.79	0.69	neutral	0.39	neutral	3.69	23.30	deleterious	0.33	0.5	0.73	disease	0.63	disease	0.3	neutral	0.47	neutral	1	1	deleterious	0.22	neutral	-2	neutral	0.84	deleterious	-3.6	low_impact	0.17	medium_impact	-0.48	medium_impact	0.71	0.85	26.37	7.13	0.24	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12835	12835	G	A	MI.20312	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	499	167	A	T	Gca/Aca	-6.47	0	0	probably_damaging	1	neutral	0.4	neutral	4.21	deleterious	-5.2	deleterious	-3.81	high_impact	4.22	0.61	neutral	0.09	damaging	4.21	23.90	deleterious	0.32	0.5	0.88	disease	0.81	disease	0.64	disease	0.76	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.14	medium_impact	2.65	high_impact	0.65	0.8	26.37	7.13	0.31	N	0.94	polymorphism	0.99	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12835	12835	G	C	MI.20313	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	499	167	A	P	Gca/Cca	-6.47	0	0	probably_damaging	1	neutral	0.2	neutral	4.2	deleterious	-6.44	deleterious	-4.83	medium_impact	3.14	0.61	neutral	0.07	damaging	3.88	23.50	deleterious	0.18	0.45	0.95	disease	0.88	disease	0.75	disease	0.85	disease	7	1	deleterious	0.1	neutral	1	deleterious	0.92	deleterious	-3.6	low_impact	-0.1	medium_impact	1.67	medium_impact	0.52	0.8	26.37	7.13	0.27	N	0.96	polymorphism	0.97	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12836	12836	C	T	MI.20314	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	500	167	A	V	gCa/gTa	3.85	1	0	probably_damaging	1	neutral	0.49	neutral	4.21	deleterious	-5.41	deleterious	-3.91	high_impact	4.78	0.56	damaging	0.07	damaging	4.41	24.10	deleterious	0.36	0.5	0.75	disease	0.81	disease	0.64	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.22	medium_impact	3.16	high_impact	0.69	0.85	26.37	7.13	0.69	P	0.76	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12836	12836	C	A	MI.20315	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	500	167	A	E	gCa/gAa	3.85	1	0	probably_damaging	1	neutral	0.27	neutral	4.23	deleterious	-4.42	deleterious	-4.8	high_impact	4.78	0.62	neutral	0.08	damaging	4.50	24.30	deleterious	0.14	0.4	0.86	disease	0.88	disease	0.75	disease	0.81	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.01	medium_impact	3.16	high_impact	0.61	0.8	26.37	7.13	0.75	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12836	12836	C	G	MI.20316	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	500	167	A	G	gCa/gGa	3.85	1	0	probably_damaging	1	neutral	0.34	neutral	4.23	deleterious	-3.77	deleterious	-3.85	medium_impact	2.64	0.62	neutral	0.12	damaging	3.92	23.50	deleterious	0.23	0.45	0.7	disease	0.78	disease	0.63	disease	0.62	disease	2	1	deleterious	0.17	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.07	medium_impact	1.21	medium_impact	0.75	0.85	26.37	7.13	0.44	N	0.82	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12838	12838	G	T	MI.20317	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	502	168	A	S	Gcc/Tcc	-7.16	0	0	probably_damaging	1	neutral	0.41	neutral	4.74	neutral	-2.52	deleterious	-2.96	medium_impact	2.02	0.47	damaging	0.22	damaging	3.70	23.30	deleterious	0.21	0.45	0.73	disease	0.84	disease	0.49	neutral	0.53	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.15	medium_impact	0.64	medium_impact	0.70	0.85	28.36	7.07	0.31	N	0.98	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12838	12838	G	C	MI.20318	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	502	168	A	P	Gcc/Ccc	-7.16	0	0	probably_damaging	1	neutral	0.21	neutral	4.4	deleterious	-6.48	deleterious	-4.93	high_impact	4.88	0.51	damaging	0.1	damaging	3.86	23.40	deleterious	0.14	0.4	0.96	disease	0.9	disease	0.74	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	-0.09	medium_impact	3.26	high_impact	0.51	0.8	28.36	7.07	0.6	P	0.96	polymorphism	0.77	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12838	12838	G	A	MI.20319	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	502	168	A	T	Gcc/Acc	-7.16	0	0	probably_damaging	1	neutral	0.4	neutral	4.51	deleterious	-3.87	deleterious	-3.95	high_impact	4.88	0.49	damaging	0.08	damaging	4.23	23.90	deleterious	0.23	0.45	0.78	disease	0.86	disease	0.62	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.14	medium_impact	3.26	high_impact	0.61	0.8	28.36	7.07	0.64	P	0.94	polymorphism	0.92	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5976	5976	T	G	MI.2032	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	73	25	W	G	Tga/Gga	-2.88	0	0	probably_damaging	1	deleterious	0.02	neutral	2.81	neutral	-2.69	deleterious	-6.11	medium_impact	3.38	0.66	neutral	0.06	damaging	3.74	23.30	deleterious	0.28	0.55	0.37	neutral	0.83	disease	0.71	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-0.75	medium_impact	2.02	high_impact	0.33	0.9	1.95	6.97	0.27	N	0.89	polymorphism	0.5	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12839	12839	C	G	MI.20320	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	503	168	A	G	gCc/gGc	5.92	1	0	probably_damaging	1	neutral	0.34	neutral	4.63	neutral	-1.89	deleterious	-3.95	low_impact	1.5	0.49	damaging	0.14	damaging	3.96	23.60	deleterious	0.22	0.45	0.66	disease	0.84	disease	0.58	disease	0.64	disease	3	1	deleterious	0.17	neutral	-2	neutral	0.83	deleterious	-3.6	low_impact	0.07	medium_impact	0.17	medium_impact	0.75	0.85	28.36	7.07	0.51	P	0.82	disease_causing	0.88	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12839	12839	C	T	MI.20321	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	503	168	A	V	gCc/gTc	5.92	1	0	probably_damaging	1	neutral	0.5	neutral	4.47	deleterious	-4.5	deleterious	-3.95	high_impact	4.88	0.4	damaging	0.07	damaging	4.43	24.20	deleterious	0.26	0.45	0.83	disease	0.86	disease	0.63	disease	0.73	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.23	medium_impact	3.26	high_impact	0.67	0.85	28.36	7.07	0.76	P	0.76	disease_causing	0.9	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12839	12839	C	A	MI.20322	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	503	168	A	D	gCc/gAc	5.92	1	0	probably_damaging	1	neutral	0.22	neutral	4.41	deleterious	-5.57	deleterious	-5.92	high_impact	4.88	0.59	damaging	0.1	damaging	4.62	24.50	deleterious	0.1	0.4	0.96	disease	0.93	disease	0.68	disease	0.81	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	-0.07	medium_impact	3.26	high_impact	0.52	0.8	28.36	7.07	0.68	P	0.95	disease_causing	0.98	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12841	12841	A	C	MI.20323	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	505	169	I	L	Att/Ctt	-1.65	0	0	benign	0.01	neutral	0.68	neutral	4.79	neutral	0.89	neutral	1.73	neutral_impact	-1.84	0.72	neutral	0.94	neutral	-0.84	0.04	neutral	0.25	0.45	0.35	neutral	0.13	neutral	0.1	neutral	0.27	neutral	5	0.29	neutral	0.84	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.41	medium_impact	-2.88	low_impact	0.58	0.8	17.25	18.65	0.39	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12841	12841	A	G	MI.20324	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	505	169	I	V	Att/Gtt	-1.65	0	0	benign	0.01	neutral	0.51	neutral	4.57	neutral	-0.7	neutral	-0.87	neutral_impact	0.22	0.76	neutral	0.66	neutral	1.13	11.35	neutral	0.52	0.6	0.59	disease	0.39	neutral	0.33	neutral	0.61	disease	2	0.47	neutral	0.75	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.24	medium_impact	-1	low_impact	0.46	0.8	17.25	18.65	0.28	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12841	12841	A	T	MI.20325	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	505	169	I	F	Att/Ttt	-1.65	0	0	possibly_damaging	0.61	neutral	0.7	neutral	4.61	neutral	-0.28	neutral	-1.92	neutral_impact	0.61	0.67	neutral	0.56	neutral	2.43	19.03	deleterious	0.36	0.5	0.58	disease	0.8	disease	0.49	neutral	0.66	disease	3	0.53	neutral	0.55	deleterious	-3	neutral	0.57	deleterious	-0.93	medium_impact	0.44	medium_impact	-0.65	medium_impact	0.56	0.8	17.25	18.65	0.23	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12842	12842	T	A	MI.20326	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	506	169	I	N	aTt/aAt	0.18	0.01	0	possibly_damaging	0.9	neutral	0.33	neutral	4.47	deleterious	-3.39	deleterious	-4.76	low_impact	0.84	0.67	neutral	0.5	neutral	4.23	23.90	deleterious	0.35	0.5	0.79	disease	0.86	disease	0.48	neutral	0.78	disease	6	0.91	neutral	0.22	neutral	-3	neutral	0.77	deleterious	-1.65	low_impact	0.06	medium_impact	-0.44	medium_impact	0.46	0.8	17.25	18.65	0.29	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12842	12842	T	G	MI.20327	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	506	169	I	S	aTt/aGt	0.18	0.01	0	possibly_damaging	0.75	neutral	0.42	neutral	4.5	neutral	-2.16	deleterious	-3.78	low_impact	1.3	0.71	neutral	0.68	neutral	3.94	23.50	deleterious	0.39	0.5	0.69	disease	0.77	disease	0.49	neutral	0.62	disease	2	0.75	neutral	0.34	neutral	-3	neutral	0.62	deleterious	-1.2	low_impact	0.16	medium_impact	-0.02	medium_impact	0.39	0.8	17.25	18.65	0.26	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12842	12842	T	C	MI.20328	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	506	169	I	T	aTt/aCt	0.18	0.01	0	possibly_damaging	0.48	neutral	0.41	neutral	4.55	neutral	-0.98	deleterious	-2.9	neutral_impact	0.76	0.68	neutral	0.52	neutral	1.62	13.98	neutral	0.48	0.55	0.56	disease	0.6	disease	0.47	neutral	0.51	disease	0	0.56	neutral	0.47	neutral	-3	neutral	0.49	deleterious	-0.71	medium_impact	0.15	medium_impact	-0.51	medium_impact	0.50	0.8	17.25	18.65	0.26	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12843	12843	T	G	MI.20329	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	507	169	I	M	atT/atG	7.3	0.95	0	benign	0.17	neutral	0.22	neutral	4.62	neutral	-0.2	neutral	0.36	neutral_impact	-1.33	0.75	neutral	0.88	neutral	0.45	7.07	deleterious	0.42	0.5	0.47	neutral	0.38	neutral	0.15	neutral	0.47	neutral	1	0.74	neutral	0.53	deleterious	-6	neutral	0.19	neutral	-0.09	medium_impact	-0.07	medium_impact	-2.42	low_impact	0.56	0.8	17.25	18.65	0.57	P	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5977	5977	G	C	MI.2033	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	74	25	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-1.63	deleterious	-6.56	high_impact	3.96	0.65	neutral	0.05	damaging	3.85	23.40	deleterious	0.28	0.55	0.32	neutral	0.89	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.34	0.9	1.95	6.97	0.45	N	0.89	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12843	12843	T	A	MI.20330	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	507	169	I	M	atT/atA	7.3	0.95	0	benign	0.17	neutral	0.22	neutral	4.62	neutral	-0.2	neutral	0.36	neutral_impact	-1.33	0.75	neutral	0.88	neutral	0.72	8.97	deleterious	0.42	0.5	0.47	neutral	0.38	neutral	0.15	neutral	0.47	neutral	1	0.74	neutral	0.53	deleterious	-6	neutral	0.19	neutral	-0.09	medium_impact	-0.07	medium_impact	-2.42	low_impact	0.56	0.8	17.25	18.65	0.56	P	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12844	12844	C	A	MI.20331	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	508	170	Q	K	Caa/Aaa	-6.93	0	0	probably_damaging	1	neutral	0.29	neutral	4.99	neutral	3.54	deleterious	-3.95	low_impact	1.23	0.47	damaging	0.05	damaging	3.94	23.50	deleterious	0.55	0.6	0.34	neutral	0.77	disease	0.69	disease	0.52	disease	0	1	deleterious	0.15	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.02	medium_impact	-0.08	medium_impact	0.62	0.8	27.69	7.2	0.28	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12844	12844	C	G	MI.20332	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	508	170	Q	E	Caa/Gaa	-6.93	0	0	probably_damaging	1	neutral	0.28	neutral	4.65	neutral	-0.28	deleterious	-2.96	medium_impact	2.31	0.49	damaging	0.05	damaging	3.12	22.60	deleterious	0.64	0.7	0.72	disease	0.82	disease	0.6	disease	0.62	disease	2	1	deleterious	0.14	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.01	medium_impact	0.91	medium_impact	0.70	0.85	27.69	7.2	0.28	N	0.92	polymorphism	1	0.09	rs28668242	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12845	12845	A	C	MI.20333	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	509	170	Q	P	cAa/cCa	4.31	0.99	0	probably_damaging	1	neutral	0.19	neutral	4.6	neutral	-2.7	deleterious	-5.93	high_impact	4.32	0.48	damaging	0.05	damaging	3.35	22.90	deleterious	0.27	0.45	0.92	disease	0.92	disease	0.75	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	-0.12	medium_impact	2.74	high_impact	0.64	0.8	27.69	7.2	0.54	P	0.95	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12845	12845	A	T	MI.20334	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	509	170	Q	L	cAa/cTa	4.31	0.99	0	probably_damaging	1	neutral	0.72	neutral	4.68	neutral	-0.9	deleterious	-6.92	medium_impact	2.15	0.51	damaging	0.04	damaging	3.81	23.40	deleterious	0.4	0.5	0.68	disease	0.91	disease	0.62	disease	0.66	disease	3	1	deleterious	0.36	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.46	medium_impact	0.76	medium_impact	0.32	0.8	27.69	7.2	0.39	N	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12845	12845	A	G	MI.20335	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	509	170	Q	R	cAa/cGa	4.31	0.99	0	probably_damaging	1	neutral	0.33	neutral	4.66	neutral	0.54	deleterious	-3.95	medium_impact	2.7	0.51	damaging	0.03	damaging	3.46	23.00	deleterious	0.64	0.7	0.79	disease	0.88	disease	0.68	disease	0.75	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	0.06	medium_impact	1.26	medium_impact	0.54	0.8	27.69	7.2	0.41	N	0.85	disease_causing	0.97	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12846	12846	A	C	MI.20336	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	510	170	Q	H	caA/caC	6.84	1	0	probably_damaging	1	neutral	0.51	neutral	4.61	neutral	-2.03	deleterious	-4.94	high_impact	3.62	0.54	damaging	0.03	damaging	3.46	23.00	deleterious	0.58	0.65	0.9	disease	0.81	disease	0.68	disease	0.77	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.24	medium_impact	2.1	high_impact	0.63	0.8	27.69	7.2	0.49	N	0.94	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12846	12846	A	T	MI.20337	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	510	170	Q	H	caA/caT	6.84	1	0	probably_damaging	1	neutral	0.51	neutral	4.61	neutral	-2.03	deleterious	-4.94	high_impact	3.62	0.54	damaging	0.03	damaging	3.60	23.20	deleterious	0.58	0.65	0.9	disease	0.81	disease	0.68	disease	0.77	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.24	medium_impact	2.1	high_impact	0.63	0.8	27.69	7.2	0.51	N	0.94	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12847	12847	G	C	MI.20338	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	511	171	A	P	Gca/Cca	-0.27	0.23	0	probably_damaging	1	neutral	0.21	neutral	4.44	deleterious	-6.1	deleterious	-4.94	high_impact	5	0.25	damaging	0.26	damaging	3.86	23.50	deleterious	0.18	0.45	0.94	disease	0.92	disease	0.78	disease	0.85	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	-0.09	medium_impact	3.36	high_impact	0.81	0.85	27.2	7.21	0.92	P	0.96	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12847	12847	G	T	MI.20339	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	511	171	A	S	Gca/Tca	-0.27	0.23	0	probably_damaging	1	neutral	0.42	neutral	4.47	deleterious	-3.19	deleterious	-2.96	medium_impact	3.27	0.3	damaging	0.35	neutral	3.70	23.30	deleterious	0.36	0.5	0.81	disease	0.9	disease	0.66	disease	0.75	disease	5	1	deleterious	0.21	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	0.16	medium_impact	1.78	medium_impact	0.84	0.9	27.2	7.21	0.64	P	0.98	disease_causing	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5977	5977	G	T	MI.2034	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	74	25	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.99	neutral	0.19	deleterious	-6.11	medium_impact	3.16	0.69	neutral	0.03	damaging	4.06	23.70	deleterious	0.25	0.55	0.2	neutral	0.86	disease	0.55	disease	0.56	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-0.92	medium_impact	1.82	medium_impact	0.24	0.9	1.95	6.97	0.42	N	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12847	12847	G	A	MI.20340	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	511	171	A	T	Gca/Aca	-0.27	0.23	0	probably_damaging	1	neutral	0.48	neutral	4.53	deleterious	-3.52	deleterious	-3.95	medium_impact	2.32	0.26	damaging	0.21	damaging	4.27	24.00	deleterious	0.45	0.55	0.55	disease	0.88	disease	0.66	disease	0.66	disease	3	1	deleterious	0.24	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.21	medium_impact	0.92	medium_impact	0.65	0.8	27.2	7.21	0.86	P	0.94	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12848	12848	C	G	MI.20341	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	512	171	A	G	gCa/gGa	7.3	1	0	probably_damaging	1	neutral	0.38	neutral	4.45	deleterious	-4.27	deleterious	-3.95	high_impact	3.9	0.25	damaging	0.37	neutral	3.92	23.50	deleterious	0.25	0.45	0.92	disease	0.87	disease	0.65	disease	0.81	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.12	medium_impact	2.36	high_impact	0.87	0.9	27.2	7.21	0.94	P	0.82	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12848	12848	C	A	MI.20342	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	512	171	A	E	gCa/gAa	7.3	1	0	probably_damaging	1	neutral	0.33	neutral	4.45	deleterious	-5.34	deleterious	-4.94	high_impact	5	0.28	damaging	0.26	damaging	4.53	24.30	deleterious	0.13	0.4	0.92	disease	0.93	disease	0.76	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.06	medium_impact	3.36	high_impact	0.73	0.85	27.2	7.21	0.92	P	0.99	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12848	12848	C	T	MI.20343	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	512	171	A	V	gCa/gTa	7.3	1	0	probably_damaging	1	neutral	0.5	neutral	4.53	deleterious	-3.25	deleterious	-3.95	high_impact	4.46	0.13	damaging	0.2	damaging	4.41	24.10	deleterious	0.52	0.6	0.76	disease	0.9	disease	0.67	disease	0.73	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.23	medium_impact	2.87	high_impact	0.72	0.85	27.2	7.21	0.95	P	0.76	disease_causing_automatic	1	0.26	rs267606899	Pathogenic	Leber's_optic_atrophy	24743	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	C12848T	LHON	-	+	Reported	3	P	P	P	damaging
chrM	12850	12850	A	C	MI.20344	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	514	172	I	L	Atc/Ctc	-5.55	0	0	possibly_damaging	0.61	neutral	0.67	neutral	4.65	neutral	1.03	neutral	-1.8	low_impact	1.55	0.71	neutral	0.4	neutral	3.75	23.30	deleterious	0.36	0.5	0.37	neutral	0.73	disease	0.58	disease	0.7	disease	4	0.53	neutral	0.53	deleterious	-3	neutral	0.69	deleterious	-0.93	medium_impact	0.4	medium_impact	0.21	medium_impact	0.64	0.8	6.8	9.63	0.23	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12850	12850	A	T	MI.20345	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	514	172	I	F	Atc/Ttc	-5.55	0	0	probably_damaging	0.97	neutral	0.7	neutral	4.83	neutral	2.01	deleterious	-3.77	low_impact	1.28	0.65	neutral	0.37	neutral	3.83	23.40	deleterious	0.37	0.5	0.37	neutral	0.81	disease	0.64	disease	0.56	disease	1	0.97	neutral	0.37	neutral	-2	neutral	0.75	deleterious	-2.18	low_impact	0.44	medium_impact	-0.03	medium_impact	0.75	0.85	6.8	9.63	0.27	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12850	12850	A	G	MI.20346	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	514	172	I	V	Atc/Gtc	-5.55	0	0	benign	0.12	neutral	0.52	neutral	4.6	neutral	-0.23	neutral	-0.52	neutral_impact	0.35	0.84	neutral	0.99	neutral	0.26	5.29	deleterious	0.53	0.6	0.5	disease	0.07	neutral	0.28	neutral	0.18	neutral	6	0.39	neutral	0.7	deleterious	-6	neutral	0.63	deleterious	0.08	medium_impact	0.25	medium_impact	-0.88	medium_impact	0.61	0.8	6.8	9.63	0.33	N	0.25	polymorphism	1	0.02	rs28705385	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12851	12851	T	A	MI.20347	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	515	172	I	N	aTc/aAc	-0.04	0.02	0	probably_damaging	0.98	neutral	0.34	neutral	4.46	deleterious	-4.1	deleterious	-6.47	high_impact	4.03	0.67	neutral	0.36	neutral	4.56	24.40	deleterious	0.17	0.45	0.9	disease	0.91	disease	0.6	disease	0.8	disease	6	0.99	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	0.07	medium_impact	2.48	high_impact	0.61	0.8	6.8	9.63	0.37	N	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12851	12851	T	G	MI.20348	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	515	172	I	S	aTc/aGc	-0.04	0.02	0	probably_damaging	0.96	neutral	0.44	neutral	4.49	neutral	-2.53	deleterious	-5.48	medium_impact	3.48	0.69	neutral	0.42	neutral	4.23	23.90	deleterious	0.22	0.45	0.51	disease	0.87	disease	0.6	disease	0.76	disease	5	0.96	neutral	0.24	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	0.18	medium_impact	1.98	medium_impact	0.56	0.8	6.8	9.63	0.32	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12851	12851	T	C	MI.20349	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	515	172	I	T	aTc/aCc	-0.04	0.02	0	probably_damaging	0.91	neutral	0.42	neutral	4.52	neutral	-1.77	deleterious	-4.35	high_impact	4.03	0.66	neutral	0.37	neutral	3.41	23.00	deleterious	0.38	0.5	0.75	disease	0.75	disease	0.57	disease	0.71	disease	4	0.91	neutral	0.26	neutral	2	deleterious	0.81	deleterious	-1.7	low_impact	0.16	medium_impact	2.48	high_impact	0.65	0.8	6.8	9.63	0.36	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5978	5978	A	C	MI.2035	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	75	25	W	C	tgA/tgC	9.38	1	0.01	probably_damaging	1	deleterious	0	neutral	2.77	deleterious	-4.04	deleterious	-6.11	high_impact	3.8	0.6	damaging	0.04	damaging	3.86	23.50	deleterious	0.31	0.55	0.65	disease	0.92	disease	0.68	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.41	high_impact	0.32	0.9	1.95	6.97	0.43	N	0.88	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12852	12852	C	A	MI.20350	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	516	172	I	M	atC/atA	7.3	0.95	0	probably_damaging	0.97	neutral	0.23	neutral	4.52	neutral	-0.62	neutral	-2.34	low_impact	1.32	0.77	neutral	0.95	neutral	2.78	21.30	deleterious	0.4	0.5	0.7	disease	0.54	disease	0.38	neutral	0.51	disease	0	0.98	neutral	0.13	neutral	-2	neutral	0.76	deleterious	-2.18	low_impact	-0.06	medium_impact	0	medium_impact	0.76	0.85	6.8	9.63	0.47	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12852	12852	C	G	MI.20351	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	516	172	I	M	atC/atG	7.3	0.95	0	probably_damaging	0.97	neutral	0.23	neutral	4.52	neutral	-0.62	neutral	-2.34	low_impact	1.32	0.77	neutral	0.95	neutral	2.31	18.25	deleterious	0.4	0.5	0.7	disease	0.54	disease	0.38	neutral	0.51	disease	0	0.98	neutral	0.13	neutral	-2	neutral	0.76	deleterious	-2.18	low_impact	-0.06	medium_impact	0	medium_impact	0.76	0.85	6.8	9.63	0.47	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12853	12853	C	G	MI.20352	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	517	173	L	V	Cta/Gta	-7.84	0	0	probably_damaging	1	neutral	0.57	neutral	4.25	neutral	-1.07	deleterious	-2.71	low_impact	1.61	0.8	neutral	0.43	neutral	2.26	17.88	deleterious	0.4	0.5	0.6	disease	0.5	neutral	0.36	neutral	0.49	neutral	0	1	deleterious	0.29	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.3	medium_impact	0.27	medium_impact	0.72	0.85	11.44	6.92	0.2	N	0.62	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12853	12853	C	A	MI.20353	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	517	173	L	M	Cta/Ata	-7.84	0	0	probably_damaging	1	neutral	0.32	neutral	4.11	deleterious	-3.38	neutral	-1.91	medium_impact	2.44	0.77	neutral	0.28	damaging	3.62	23.20	deleterious	0.33	0.5	0.89	disease	0.53	disease	0.38	neutral	0.64	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.05	medium_impact	1.03	medium_impact	0.74	0.85	11.44	6.92	0.28	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12854	12854	T	A	MI.20354	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	518	173	L	Q	cTa/cAa	-2.11	0	0	probably_damaging	1	neutral	0.32	neutral	4.07	deleterious	-5.81	deleterious	-5.86	high_impact	4.2	0.73	neutral	0.1	damaging	4.03	23.60	deleterious	0.17	0.45	0.8	disease	0.82	disease	0.58	disease	0.74	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.05	medium_impact	2.63	high_impact	0.73	0.85	11.44	6.92	0.32	N	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12854	12854	T	G	MI.20355	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	518	173	L	R	cTa/cGa	-2.11	0	0	probably_damaging	1	neutral	0.38	neutral	4.07	deleterious	-5.34	deleterious	-5.87	high_impact	4.2	0.68	neutral	0.08	damaging	4.14	23.80	deleterious	0.14	0.4	0.93	disease	0.92	disease	0.7	disease	0.83	disease	7	1	deleterious	0.19	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	0.12	medium_impact	2.63	high_impact	0.56	0.8	11.44	6.92	0.3	N	0.96	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12854	12854	T	C	MI.20356	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	518	173	L	P	cTa/cCa	-2.11	0	0	probably_damaging	1	neutral	0.21	neutral	4.07	deleterious	-6.31	deleterious	-6.79	high_impact	3.86	0.64	neutral	0.08	damaging	3.87	23.50	deleterious	0.16	0.45	0.71	disease	0.92	disease	0.71	disease	0.78	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.09	medium_impact	2.32	high_impact	0.68	0.85	11.44	6.92	0.29	N	0.89	polymorphism	1	0.31	.	.	.	.	.	.	COSM488735	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12856	12856	T	A	MI.20357	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	520	174	Y	N	Tac/Aac	-6.7	0	0	probably_damaging	1	neutral	0.33	neutral	4.45	deleterious	-4.89	deleterious	-8.77	medium_impact	3.38	0.58	damaging	0.11	damaging	3.92	23.50	deleterious	0.33	0.5	0.85	disease	0.93	disease	0.71	disease	0.79	disease	6	1	deleterious	0.17	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.06	medium_impact	1.88	medium_impact	0.53	0.8	15.42	7.13	0.3	N	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12856	12856	T	C	MI.20358	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	520	174	Y	H	Tac/Cac	-6.7	0	0	probably_damaging	1	neutral	0.5	neutral	4.45	deleterious	-5.37	deleterious	-4.9	high_impact	4.08	0.61	neutral	0.08	damaging	3.48	23.10	deleterious	0.4	0.5	0.93	disease	0.9	disease	0.79	disease	0.85	disease	7	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.23	medium_impact	2.52	high_impact	0.68	0.85	15.42	7.13	0.36	N	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12856	12856	T	G	MI.20359	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	520	174	Y	D	Tac/Gac	-6.7	0	0	probably_damaging	1	neutral	0.22	neutral	4.44	deleterious	-6.12	deleterious	-9.72	high_impact	4.08	0.64	neutral	0.11	damaging	3.84	23.40	deleterious	0.19	0.45	0.95	disease	0.94	disease	0.78	disease	0.85	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.07	medium_impact	2.52	high_impact	0.55	0.8	15.42	7.13	0.38	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5978	5978	A	T	MI.2036	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	75	25	W	C	tgA/tgT	9.38	1	0.01	probably_damaging	1	deleterious	0	neutral	2.77	deleterious	-4.04	deleterious	-6.11	high_impact	3.8	0.6	damaging	0.04	damaging	3.93	23.50	deleterious	0.31	0.55	0.65	disease	0.92	disease	0.68	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.41	high_impact	0.32	0.9	1.95	6.97	0.44	N	0.88	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12857	12857	A	G	MI.20360	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	521	174	Y	C	tAc/tGc	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	4.45	deleterious	-4.33	deleterious	-8.73	medium_impact	3.38	0.61	neutral	0.08	damaging	3.39	23.00	deleterious	0.34	0.5	0.92	disease	0.94	disease	0.74	disease	0.83	disease	7	1	deleterious	0.09	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	-0.13	medium_impact	1.88	medium_impact	0.36	0.8	15.42	7.13	0.48	N	1.00	disease_causing	0.87	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12857	12857	A	C	MI.20361	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	521	174	Y	S	tAc/tCc	7.3	1	0	probably_damaging	1	neutral	0.46	neutral	4.49	deleterious	-3.19	deleterious	-8.73	low_impact	1.9	0.64	neutral	0.12	damaging	3.65	23.20	deleterious	0.36	0.5	0.42	neutral	0.92	disease	0.7	disease	0.69	disease	4	1	deleterious	0.23	neutral	-2	neutral	0.83	deleterious	-3.6	low_impact	0.19	medium_impact	0.53	medium_impact	0.66	0.8	15.42	7.13	0.4	N	0.97	disease_causing	0.81	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12857	12857	A	T	MI.20362	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	521	174	Y	F	tAc/tTc	7.3	1	0	probably_damaging	1	neutral	0.69	neutral	4.48	neutral	-1.56	deleterious	-3.67	medium_impact	2.42	0.58	damaging	0.14	damaging	3.24	22.80	deleterious	0.39	0.5	0.74	disease	0.92	disease	0.65	disease	0.66	disease	3	1	deleterious	0.35	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.42	medium_impact	1.01	medium_impact	0.74	0.85	15.42	7.13	0.49	N	0.80	polymorphism	0.75	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12859	12859	A	T	MI.20363	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	523	175	N	Y	Aac/Tac	-4.86	0	0	probably_damaging	1	neutral	1	neutral	4.46	deleterious	-3.5	deleterious	-7.91	high_impact	5.03	0.32	damaging	0.2	damaging	3.50	23.10	deleterious	0.32	0.5	0.81	disease	0.94	disease	0.73	disease	0.84	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.6	low_impact	1.89	high_impact	3.39	high_impact	0.68	0.85	29.35	7.2	0.65	P	0.99	disease_causing	0.94	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12859	12859	A	C	MI.20364	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	523	175	N	H	Aac/Cac	-4.86	0	0	probably_damaging	1	neutral	0.54	neutral	4.47	deleterious	-4.25	deleterious	-4.94	high_impact	5.03	0.31	damaging	0.21	damaging	2.95	22.00	deleterious	0.41	0.5	0.92	disease	0.89	disease	0.77	disease	0.85	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.27	medium_impact	3.39	high_impact	0.65	0.8	29.35	7.2	0.73	P	0.97	disease_causing	0.78	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12859	12859	A	G	MI.20365	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	523	175	N	D	Aac/Gac	-4.86	0	0	probably_damaging	1	neutral	0.24	neutral	4.5	deleterious	-4.31	deleterious	-4.94	high_impact	5.03	0.36	damaging	0.31	neutral	3.68	23.30	deleterious	0.5	0.6	0.9	disease	0.88	disease	0.78	disease	0.83	disease	7	1	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.04	medium_impact	3.39	high_impact	0.73	0.85	29.35	7.2	0.77	P	0.94	disease_causing	0.62	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12860	12860	A	C	MI.20366	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	524	175	N	T	aAc/aCc	6.84	1	0	probably_damaging	1	neutral	0.41	neutral	4.69	neutral	0.64	deleterious	-5.93	medium_impact	2.36	0.32	damaging	0.28	neutral	3.79	23.40	deleterious	0.55	0.6	0.47	neutral	0.9	disease	0.71	disease	0.75	disease	5	1	deleterious	0.21	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.15	medium_impact	0.95	medium_impact	0.78	0.85	29.35	7.2	0.72	P	0.94	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12860	12860	A	T	MI.20367	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	524	175	N	I	aAc/aTc	6.84	1	0	probably_damaging	1	neutral	0.41	neutral	4.46	neutral	-2.52	deleterious	-8.89	high_impact	5.03	0.3	damaging	0.42	neutral	4.37	24.10	deleterious	0.36	0.5	0.7	disease	0.96	disease	0.7	disease	0.83	disease	7	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.15	medium_impact	3.39	high_impact	0.66	0.8	29.35	7.2	0.83	P	0.99	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12860	12860	A	G	MI.20368	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	524	175	N	S	aAc/aGc	6.84	1	0	probably_damaging	1	neutral	0.44	neutral	4.6	neutral	-1.52	deleterious	-4.94	high_impact	4.34	0.34	damaging	0.35	neutral	3.55	23.10	deleterious	0.67	0.7	0.68	disease	0.89	disease	0.67	disease	0.73	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.18	medium_impact	2.76	high_impact	0.59	0.8	29.35	7.2	0.8	P	0.82	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12861	12861	C	A	MI.20369	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	525	175	N	K	aaC/aaA	8.44	1	0	probably_damaging	1	neutral	0.34	neutral	4.54	deleterious	-3.17	deleterious	-5.93	high_impact	3.5	0.3	damaging	0.25	damaging	4.34	24.00	deleterious	0.53	0.6	0.74	disease	0.93	disease	0.76	disease	0.82	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.07	medium_impact	1.99	medium_impact	0.76	0.85	29.35	7.2	0.77	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5979	5979	G	C	MI.2037	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	76	26	A	P	Gct/Cct	-0.11	0.56	0	probably_damaging	1	deleterious	0.01	neutral	2.64	deleterious	-3.7	neutral	-1.92	high_impact	4.09	0.56	damaging	0.4	neutral	3.70	23.30	deleterious	0.12	0.55	0.71	disease	0.91	disease	0.65	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-0.92	medium_impact	2.68	high_impact	0.80	0.9	2.14	7.08	0.36	N	0.85	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12861	12861	C	G	MI.20370	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	525	175	N	K	aaC/aaG	8.44	1	0	probably_damaging	1	neutral	0.34	neutral	4.54	deleterious	-3.17	deleterious	-5.93	high_impact	3.5	0.3	damaging	0.25	damaging	3.93	23.50	deleterious	0.53	0.6	0.74	disease	0.93	disease	0.76	disease	0.82	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.07	medium_impact	1.99	medium_impact	0.76	0.85	29.35	7.2	0.76	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12862	12862	C	G	MI.20371	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	526	176	R	G	Cgt/Ggt	-1.19	0.01	0	probably_damaging	1	neutral	0.37	neutral	4.54	neutral	-2.3	deleterious	-6.92	medium_impact	3.27	0.3	damaging	0.08	damaging	4.12	23.80	deleterious	0.34	0.5	0.66	disease	0.88	disease	0.75	disease	0.75	disease	5	1	deleterious	0.19	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.11	medium_impact	1.78	medium_impact	0.46	0.8	28.69	7.19	0.56	P	0.97	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12862	12862	C	T	MI.20372	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	526	176	R	C	Cgt/Tgt	-1.19	0.01	0	probably_damaging	1	neutral	0.18	neutral	4.46	deleterious	-5.34	deleterious	-7.91	high_impact	4.76	0.38	damaging	0.04	damaging	4.92	25.00	deleterious	0.35	0.5	0.96	disease	0.91	disease	0.73	disease	0.8	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.13	medium_impact	3.15	high_impact	0.76	0.85	28.69	7.19	0.58	P	1.00	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12862	12862	C	A	MI.20373	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	526	176	R	S	Cgt/Agt	-1.19	0.01	0	probably_damaging	1	neutral	0.47	neutral	4.55	neutral	-2.2	deleterious	-5.93	high_impact	4.21	0.39	damaging	0.07	damaging	4.66	24.50	deleterious	0.35	0.5	0.72	disease	0.9	disease	0.74	disease	0.74	disease	5	1	deleterious	0.24	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.2	medium_impact	2.64	high_impact	0.51	0.8	28.69	7.19	0.52	P	0.82	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12863	12863	G	C	MI.20374	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	527	176	R	P	cGt/cCt	3.4	0.99	0	probably_damaging	1	neutral	0.22	neutral	4.47	deleterious	-5.28	deleterious	-6.92	high_impact	5.11	0.34	damaging	0.06	damaging	4.19	23.80	deleterious	0.28	0.45	0.91	disease	0.93	disease	0.84	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.07	medium_impact	3.47	high_impact	0.29	0.8	28.69	7.19	0.72	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12863	12863	G	A	MI.20375	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	527	176	R	H	cGt/cAt	3.4	0.99	0	probably_damaging	1	neutral	0.53	neutral	4.47	neutral	-2.96	deleterious	-4.94	high_impact	4.76	0.35	damaging	0.04	damaging	4.32	24.00	deleterious	0.58	0.65	0.81	disease	0.88	disease	0.77	disease	0.78	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.26	medium_impact	3.15	high_impact	0.78	0.85	28.69	7.19	0.78	P	1.00	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12863	12863	G	T	MI.20376	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	527	176	R	L	cGt/cTt	3.4	0.99	0	probably_damaging	1	neutral	0.68	neutral	4.58	neutral	-1.01	deleterious	-6.92	high_impact	5.11	0.29	damaging	0.05	damaging	4.26	23.90	deleterious	0.38	0.5	0.68	disease	0.96	disease	0.72	disease	0.82	disease	6	1	deleterious	0.34	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.41	medium_impact	3.47	high_impact	0.48	0.8	28.69	7.19	0.75	P	1.00	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12865	12865	A	C	MI.20377	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	529	177	I	L	Atc/Ctc	-4.4	0	0	probably_damaging	1	neutral	0.81	neutral	4.65	neutral	0.24	neutral	-1.92	low_impact	1.19	0.74	neutral	0.68	neutral	3.75	23.30	deleterious	0.39	0.5	0.46	neutral	0.84	disease	0.51	disease	0.52	disease	0	1	deleterious	0.41	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.58	medium_impact	-0.12	medium_impact	0.84	0.9	6.8	7.21	0.24	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12865	12865	A	G	MI.20378	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	529	177	I	V	Atc/Gtc	-4.4	0	0	probably_damaging	1	neutral	0.79	neutral	4.6	neutral	0.82	neutral	-0.96	neutral_impact	0.36	0.71	neutral	0.76	neutral	0.93	10.28	neutral	0.6	0.65	0.33	neutral	0.14	neutral	0.34	neutral	0.23	neutral	5	1	deleterious	0.4	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.55	medium_impact	-0.87	medium_impact	0.60	0.8	6.8	7.21	0.28	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12865	12865	A	T	MI.20379	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	529	177	I	F	Atc/Ttc	-4.4	0	0	probably_damaging	1	neutral	0.79	neutral	4.57	neutral	-0.56	deleterious	-3.89	low_impact	1.64	0.66	neutral	0.34	neutral	3.79	23.40	deleterious	0.44	0.55	0.6	disease	0.92	disease	0.65	disease	0.69	disease	4	1	deleterious	0.4	neutral	-2	neutral	0.84	deleterious	-3.6	low_impact	0.55	medium_impact	0.3	medium_impact	0.77	0.85	6.8	7.21	0.18	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5979	5979	G	A	MI.2038	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	76	26	A	T	Gct/Act	-0.11	0.56	0	probably_damaging	1	deleterious	0.02	neutral	2.69	neutral	-1.58	neutral	-1.17	medium_impact	2.64	0.53	damaging	0.39	neutral	4.01	23.60	deleterious	0.41	0.55	0.37	neutral	0.66	disease	0.43	neutral	0.52	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-0.75	medium_impact	1.34	medium_impact	0.80	0.9	2.14	7.08	0.41	N	0.20	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12866	12866	T	A	MI.20380	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	530	177	I	N	aTc/aAc	0.18	0.01	0	probably_damaging	1	neutral	0.63	neutral	4.39	deleterious	-4.74	deleterious	-6.83	high_impact	4.36	0.67	neutral	0.35	neutral	4.32	24.00	deleterious	0.31	0.45	0.92	disease	0.94	disease	0.65	disease	0.82	disease	6	1	deleterious	0.32	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.36	medium_impact	2.78	high_impact	0.57	0.8	6.8	7.21	0.37	N	0.97	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12866	12866	T	G	MI.20381	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	530	177	I	S	aTc/aGc	0.18	0.01	0	probably_damaging	1	neutral	0.86	neutral	4.42	neutral	-2.79	deleterious	-5.84	medium_impact	3.46	0.69	neutral	0.4	neutral	4.21	23.90	deleterious	0.35	0.5	0.76	disease	0.92	disease	0.64	disease	0.74	disease	5	1	deleterious	0.43	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.67	medium_impact	1.96	medium_impact	0.50	0.8	6.8	7.21	0.25	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12866	12866	T	C	MI.20382	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	530	177	I	T	aTc/aCc	0.18	0.01	0	probably_damaging	1	neutral	0.74	neutral	4.46	neutral	-1.93	deleterious	-4.87	medium_impact	2.69	0.81	neutral	0.59	neutral	3.36	22.90	deleterious	0.58	0.65	0.65	disease	0.82	disease	0.56	disease	0.64	disease	3	1	deleterious	0.37	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.48	medium_impact	1.25	medium_impact	0.68	0.85	6.8	7.21	0.2	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12867	12867	C	G	MI.20383	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	531	177	I	M	atC/atG	5.69	0.87	0	probably_damaging	1	neutral	0.4	neutral	4.43	neutral	-2.44	deleterious	-2.82	medium_impact	3.12	0.79	neutral	0.66	neutral	3.27	22.80	deleterious	0.47	0.55	0.77	disease	0.77	disease	0.54	disease	0.58	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.14	medium_impact	1.65	medium_impact	0.85	0.9	6.8	7.21	0.41	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12867	12867	C	A	MI.20384	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	531	177	I	M	atC/atA	5.69	0.87	0	probably_damaging	1	neutral	0.4	neutral	4.43	neutral	-2.44	deleterious	-2.82	medium_impact	3.12	0.79	neutral	0.66	neutral	3.77	23.40	deleterious	0.47	0.55	0.77	disease	0.77	disease	0.54	disease	0.58	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.14	medium_impact	1.65	medium_impact	0.85	0.9	6.8	7.21	0.41	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12868	12868	G	A	MI.20385	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	532	178	G	S	Ggc/Agc	-8.3	0	0	probably_damaging	1	neutral	0.5	neutral	4.49	deleterious	-3.21	deleterious	-5.93	medium_impact	3.44	0.4	damaging	0.11	damaging	4.10	23.70	deleterious	0.2	0.45	0.5	neutral	0.91	disease	0.73	disease	0.76	disease	5	1	deleterious	0.25	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.23	medium_impact	1.94	medium_impact	0.77	0.85	29.02	7.24	0.43	N	1.00	disease_causing	0.85	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12868	12868	G	T	MI.20386	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	532	178	G	C	Ggc/Tgc	-8.3	0	0	probably_damaging	1	neutral	0.18	neutral	4.08	deleterious	-6.7	deleterious	-8.89	high_impact	5.17	0.38	damaging	0.08	damaging	4.04	23.70	deleterious	0.11	0.4	0.98	disease	0.94	disease	0.74	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.13	medium_impact	3.52	high_impact	0.54	0.8	29.02	7.24	0.51	P	0.97	disease_causing	0.96	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12868	12868	G	C	MI.20387	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	532	178	G	R	Ggc/Cgc	-8.3	0	0	probably_damaging	1	neutral	0.42	neutral	4.06	deleterious	-6.5	deleterious	-7.91	high_impact	4.82	0.42	damaging	0.09	damaging	3.82	23.40	deleterious	0.08	0.35	0.89	disease	0.95	disease	0.84	disease	0.86	disease	7	1	deleterious	0.21	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	0.16	medium_impact	3.2	high_impact	0.61	0.8	29.02	7.24	0.58	P	1.00	disease_causing	0.92	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12869	12869	G	A	MI.20388	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	533	178	G	D	gGc/gAc	5.92	1	0	probably_damaging	1	neutral	0.28	neutral	4.05	deleterious	-6.81	deleterious	-6.92	high_impact	5.17	0.46	damaging	0.09	damaging	3.75	23.30	deleterious	0.08	0.35	0.9	disease	0.94	disease	0.82	disease	0.86	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.01	medium_impact	3.52	high_impact	0.43	0.8	29.02	7.24	0.69	P	0.95	disease_causing	1	0.44	.	.	.	.	.	.	COSM1636303	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12869	12869	G	T	MI.20389	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	533	178	G	V	gGc/gTc	5.92	1	0	probably_damaging	1	neutral	0.55	neutral	4.07	deleterious	-5.4	deleterious	-8.89	high_impact	5.17	0.32	damaging	0.08	damaging	3.74	23.30	deleterious	0.09	0.4	0.89	disease	0.95	disease	0.76	disease	0.84	disease	7	1	deleterious	0.28	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.28	medium_impact	3.52	high_impact	0.50	0.8	29.02	7.24	0.69	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5979	5979	G	T	MI.2039	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	76	26	A	S	Gct/Tct	-0.11	0.56	0	probably_damaging	1	neutral	0.63	neutral	2.71	neutral	-1.2	neutral	-0.42	neutral_impact	-0.2	0.56	damaging	0.67	neutral	1.68	14.32	neutral	0.43	0.55	0.31	neutral	0.16	neutral	0.2	neutral	0.29	neutral	4	1	deleterious	0.32	neutral	-2	neutral	0.68	deleterious	-3.58	low_impact	0.32	medium_impact	-1.28	low_impact	0.80	0.9	2.14	7.08	0.35	N	0.64	disease_causing	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12869	12869	G	C	MI.20390	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	533	178	G	A	gGc/gCc	5.92	1	0	probably_damaging	1	neutral	0.6	neutral	4.26	neutral	-2.7	deleterious	-5.93	medium_impact	3.03	0.45	damaging	0.24	damaging	3.11	22.50	deleterious	0.28	0.45	0.73	disease	0.82	disease	0.7	disease	0.69	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.33	medium_impact	1.57	medium_impact	0.73	0.85	29.02	7.24	0.54	P	0.79	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12871	12871	G	C	MI.20391	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	535	179	D	H	Gat/Cat	-9.91	0	0	probably_damaging	1	neutral	0.52	neutral	4.29	deleterious	-4.95	deleterious	-6.92	high_impact	5.13	0.4	damaging	0.02	damaging	3.65	23.20	deleterious	0.41	0.5	0.9	disease	0.93	disease	0.81	disease	0.82	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.25	medium_impact	3.48	high_impact	0.68	0.85	26.7	7.19	0.57	P	0.99	polymorphism	0.72	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12871	12871	G	A	MI.20392	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	535	179	D	N	Gat/Aat	-9.91	0	0	probably_damaging	1	neutral	0.33	neutral	4.32	deleterious	-3.37	deleterious	-4.94	high_impact	5.13	0.33	damaging	0.03	damaging	4.16	23.80	deleterious	0.61	0.65	0.83	disease	0.92	disease	0.73	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.06	medium_impact	3.48	high_impact	0.78	0.85	26.7	7.19	0.62	P	0.98	polymorphism	0.93	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12871	12871	G	T	MI.20393	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	535	179	D	Y	Gat/Tat	-9.91	0	0	probably_damaging	1	neutral	1	neutral	4.29	deleterious	-5.86	deleterious	-8.89	high_impact	5.13	0.38	damaging	0.03	damaging	3.92	23.50	deleterious	0.29	0.45	0.92	disease	0.97	disease	0.77	disease	0.83	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.90	deleterious	-3.6	low_impact	1.89	high_impact	3.48	high_impact	0.57	0.8	26.7	7.19	0.53	P	0.99	polymorphism	0.55	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12872	12872	A	C	MI.20394	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	536	179	D	A	gAt/gCt	7.07	1	0	probably_damaging	1	neutral	0.52	neutral	4.39	neutral	-1.85	deleterious	-7.91	high_impact	4.58	0.38	damaging	0.03	damaging	3.67	23.30	deleterious	0.3	0.45	0.75	disease	0.92	disease	0.73	disease	0.73	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.25	medium_impact	2.98	high_impact	0.62	0.8	26.7	7.19	0.67	P	0.94	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12872	12872	A	T	MI.20395	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	536	179	D	V	gAt/gTt	7.07	1	0	probably_damaging	1	neutral	0.52	neutral	4.3	deleterious	-4.58	deleterious	-8.89	high_impact	5.13	0.35	damaging	0.03	damaging	3.85	23.40	deleterious	0.25	0.45	0.81	disease	0.96	disease	0.75	disease	0.83	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.25	medium_impact	3.48	high_impact	0.54	0.8	26.7	7.19	0.67	P	0.99	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12872	12872	A	G	MI.20396	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	536	179	D	G	gAt/gGt	7.07	1	0	probably_damaging	1	neutral	0.36	neutral	4.31	deleterious	-3.67	deleterious	-6.92	medium_impact	2.7	0.39	damaging	0.03	damaging	4.02	23.60	deleterious	0.36	0.5	0.5	disease	0.93	disease	0.71	disease	0.77	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.1	medium_impact	1.26	medium_impact	0.56	0.8	26.7	7.19	0.56	P	0.98	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12873	12873	T	A	MI.20397	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	537	179	D	E	gaT/gaA	8.44	1	0	probably_damaging	1	neutral	0.29	neutral	4.35	neutral	-2.63	deleterious	-3.95	high_impact	4.58	0.38	damaging	0.02	damaging	4.01	23.60	deleterious	0.5	0.6	0.76	disease	0.91	disease	0.71	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.02	medium_impact	2.98	high_impact	0.68	0.85	26.7	7.19	0.75	P	0.91	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12873	12873	T	G	MI.20398	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	537	179	D	E	gaT/gaG	8.44	1	0	probably_damaging	1	neutral	0.29	neutral	4.35	neutral	-2.63	deleterious	-3.95	high_impact	4.58	0.38	damaging	0.02	damaging	3.89	23.50	deleterious	0.5	0.6	0.76	disease	0.91	disease	0.71	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.02	medium_impact	2.98	high_impact	0.68	0.85	26.7	7.19	0.74	P	0.91	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12874	12874	A	T	MI.20399	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	538	180	I	F	Atc/Ttc	-2.8	0	0	probably_damaging	0.97	neutral	0.73	neutral	4.57	neutral	-0.1	deleterious	-3.85	low_impact	1.04	0.62	neutral	0.41	neutral	3.60	23.20	deleterious	0.61	0.65	0.53	disease	0.86	disease	0.66	disease	0.56	disease	1	0.97	neutral	0.38	neutral	-2	neutral	0.79	deleterious	-2.18	low_impact	0.47	medium_impact	-0.25	medium_impact	0.82	0.85	8.96	12.31	0.19	N	0.95	disease_causing	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8621	8621	C	T	MI.204	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	95	32	P	L	cCc/cTc	0.13	0	0	probably_damaging	1	neutral	0.27	neutral	4.47	neutral	1.97	deleterious	-7.74	low_impact	1.3	0.79	neutral	0.19	damaging	4.18	23.80	deleterious	0.42	0.65	0.55	disease	0.84	disease	0.48	neutral	0.66	disease	3	1	deleterious	0.14	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.05	medium_impact	0.02	medium_impact	0.75	0.9	29.2	19.38	0.27	N	0.39	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5980	5980	C	A	MI.2040	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	77	26	A	D	gCt/gAt	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-4.23	neutral	-2.06	high_impact	3.75	0.61	neutral	0.42	neutral	4.34	24.00	deleterious	0.14	0.55	0.63	disease	0.92	disease	0.64	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.36	high_impact	0.64	0.9	2.14	7.08	0.55	P	0.89	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12874	12874	A	C	MI.20400	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	538	180	I	L	Atc/Ctc	-2.8	0	0	possibly_damaging	0.61	neutral	0.86	neutral	4.68	neutral	1.45	neutral	-1.87	neutral_impact	0.69	0.69	neutral	0.6	neutral	3.62	23.20	deleterious	0.42	0.5	0.36	neutral	0.84	disease	0.58	disease	0.52	disease	0	0.54	neutral	0.63	deleterious	-3	neutral	0.70	deleterious	-0.93	medium_impact	0.67	medium_impact	-0.57	medium_impact	0.81	0.85	8.96	12.31	0.29	N	0.66	polymorphism	0.66	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12874	12874	A	G	MI.20401	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	538	180	I	V	Atc/Gtc	-2.8	0	0	benign	0.12	neutral	0.63	neutral	4.64	neutral	0.71	neutral	-0.57	neutral_impact	0.4	0.85	neutral	0.98	neutral	1.68	14.27	neutral	0.71	0.75	0.39	neutral	0.46	neutral	0.44	neutral	0.43	neutral	1	0.27	neutral	0.76	deleterious	-6	neutral	0.65	deleterious	0.08	medium_impact	0.36	medium_impact	-0.84	medium_impact	0.71	0.85	8.96	12.31	0.29	N	0.25	polymorphism	0.82	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12875	12875	T	C	MI.20402	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	539	180	I	T	aTc/aCc	1.33	0.52	0	probably_damaging	0.91	neutral	0.62	neutral	4.53	neutral	-1.27	deleterious	-4.45	low_impact	1.88	0.64	neutral	0.52	neutral	3.36	22.90	deleterious	0.59	0.65	0.69	disease	0.83	disease	0.64	disease	0.63	disease	3	0.9	neutral	0.36	neutral	-2	neutral	0.79	deleterious	-1.7	low_impact	0.35	medium_impact	0.51	medium_impact	0.66	0.8	8.96	12.31	0.23	N	0.96	disease_causing	0.77	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12875	12875	T	G	MI.20403	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	539	180	I	S	aTc/aGc	1.33	0.52	0	probably_damaging	0.96	neutral	0.68	neutral	4.54	neutral	-1.39	deleterious	-5.6	low_impact	1.77	0.7	neutral	0.47	neutral	4.22	23.90	deleterious	0.45	0.55	0.61	disease	0.91	disease	0.67	disease	0.74	disease	5	0.95	neutral	0.36	neutral	-2	neutral	0.82	deleterious	-2.06	low_impact	0.41	medium_impact	0.41	medium_impact	0.55	0.8	8.96	12.31	0.22	N	0.96	disease_causing	0.93	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12875	12875	T	A	MI.20404	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	539	180	I	N	aTc/aAc	1.33	0.52	0	probably_damaging	0.98	neutral	0.58	neutral	4.45	deleterious	-3.18	deleterious	-6.59	high_impact	3.64	0.59	damaging	0.41	neutral	4.32	24.00	deleterious	0.41	0.5	0.8	disease	0.94	disease	0.67	disease	0.78	disease	6	0.98	deleterious	0.3	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	0.31	medium_impact	2.12	high_impact	0.56	0.8	8.96	12.31	0.31	N	0.98	disease_causing	0.91	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12876	12876	C	A	MI.20405	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	540	180	I	M	atC/atA	5.69	0.93	0	probably_damaging	0.97	neutral	0.29	neutral	4.47	neutral	-1.31	deleterious	-2.54	low_impact	1.82	0.79	neutral	0.91	neutral	3.76	23.30	deleterious	0.61	0.65	0.75	disease	0.77	disease	0.55	disease	0.56	disease	1	0.97	neutral	0.16	neutral	-2	neutral	0.76	deleterious	-2.18	low_impact	0.02	medium_impact	0.46	medium_impact	0.82	0.85	8.96	12.31	0.42	N	0.76	disease_causing	0.9	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12876	12876	C	G	MI.20406	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	540	180	I	M	atC/atG	5.69	0.93	0	probably_damaging	0.97	neutral	0.29	neutral	4.47	neutral	-1.31	deleterious	-2.54	low_impact	1.82	0.79	neutral	0.91	neutral	3.25	22.80	deleterious	0.61	0.65	0.75	disease	0.77	disease	0.55	disease	0.56	disease	1	0.97	neutral	0.16	neutral	-2	neutral	0.76	deleterious	-2.18	low_impact	0.02	medium_impact	0.46	medium_impact	0.82	0.85	8.96	12.31	0.42	N	0.76	disease_causing	0.9	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12877	12877	G	A	MI.20407	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	541	181	G	S	Ggt/Agt	-3.94	0	0	probably_damaging	1	neutral	0.43	neutral	4.6	neutral	-2.56	deleterious	-5.93	medium_impact	3.36	0.38	damaging	0.03	damaging	4.11	23.70	deleterious	0.42	0.55	0.76	disease	0.9	disease	0.62	disease	0.69	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.17	medium_impact	1.87	medium_impact	0.73	0.85	27.69	7.23	0.45	N	1.00	disease_causing	0.95	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12877	12877	G	C	MI.20408	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	541	181	G	R	Ggt/Cgt	-3.94	0	0	probably_damaging	1	neutral	0.37	neutral	4.58	deleterious	-5.09	deleterious	-7.91	high_impact	4.71	0.42	damaging	0.03	damaging	3.87	23.50	deleterious	0.14	0.4	0.88	disease	0.96	disease	0.75	disease	0.83	disease	7	1	deleterious	0.19	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.11	medium_impact	3.1	high_impact	0.60	0.8	27.69	7.23	0.55	P	1.00	disease_causing	0.98	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12877	12877	G	T	MI.20409	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	541	181	G	C	Ggt/Tgt	-3.94	0	0	probably_damaging	1	neutral	0.18	neutral	4.57	deleterious	-4.03	deleterious	-8.89	medium_impact	2.78	0.37	damaging	0.02	damaging	4.08	23.70	deleterious	0.24	0.45	0.84	disease	0.94	disease	0.66	disease	0.77	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	-0.13	medium_impact	1.34	medium_impact	0.55	0.8	27.69	7.23	0.46	N	0.97	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5980	5980	C	T	MI.2041	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	77	26	A	V	gCt/gTt	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.75	neutral	-0.55	neutral	-1.75	medium_impact	3.06	0.55	damaging	0.41	neutral	4.16	23.80	deleterious	0.38	0.55	0.4	neutral	0.76	disease	0.51	disease	0.61	disease	2	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	1.73	medium_impact	0.76	0.9	2.14	7.08	0.56	P	0.75	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12878	12878	G	A	MI.20410	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	542	181	G	D	gGt/gAt	9.13	1	0	probably_damaging	1	neutral	0.23	neutral	4.57	deleterious	-6.27	deleterious	-6.92	high_impact	4.71	0.36	damaging	0.02	damaging	3.70	23.30	deleterious	0.2	0.45	0.94	disease	0.94	disease	0.74	disease	0.82	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.06	medium_impact	3.1	high_impact	0.44	0.8	27.69	7.23	0.72	P	0.95	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12878	12878	G	T	MI.20411	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	542	181	G	V	gGt/gTt	9.13	1	0	probably_damaging	1	neutral	0.51	neutral	4.69	neutral	-1.75	deleterious	-8.89	medium_impact	3.29	0.34	damaging	0.03	damaging	3.78	23.40	deleterious	0.34	0.5	0.5	neutral	0.95	disease	0.63	disease	0.77	disease	5	1	deleterious	0.26	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.24	medium_impact	1.8	medium_impact	0.54	0.8	27.69	7.23	0.59	P	0.98	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12878	12878	G	C	MI.20412	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	542	181	G	A	gGt/gCt	9.13	1	0	probably_damaging	1	neutral	0.54	neutral	4.64	neutral	-1.1	deleterious	-5.93	medium_impact	2.24	0.38	damaging	0.05	damaging	3.18	22.70	deleterious	0.55	0.6	0.53	disease	0.84	disease	0.61	disease	0.65	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.27	medium_impact	0.84	medium_impact	0.71	0.85	27.69	7.23	0.58	P	0.79	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12880	12880	T	A	MI.20413	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	544	182	F	I	Ttc/Atc	-10.14	0	0.06	possibly_damaging	0.81	neutral	0.55	neutral	4.69	neutral	0.38	deleterious	-4.65	neutral_impact	0.66	0.75	neutral	0.73	neutral	4.40	24.10	deleterious	0.3	0.45	0.42	neutral	0.85	disease	0.51	disease	0.54	disease	1	0.79	neutral	0.37	neutral	-3	neutral	0.76	deleterious	-1.34	low_impact	0.28	medium_impact	-0.6	medium_impact	0.63	0.8	4.48	9.53	0.28	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12880	12880	T	G	MI.20414	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	544	182	F	V	Ttc/Gtc	-10.14	0	0.06	possibly_damaging	0.81	neutral	0.67	neutral	4.58	neutral	-0.82	deleterious	-5.64	medium_impact	2.63	0.73	neutral	0.53	neutral	4.10	23.70	deleterious	0.3	0.45	0.64	disease	0.9	disease	0.6	disease	0.72	disease	4	0.78	neutral	0.43	neutral	0	NA	0.80	deleterious	-1.34	low_impact	0.4	medium_impact	1.2	medium_impact	0.64	0.8	4.48	9.53	0.23	N	0.93	polymorphism	1	0.08	rs28719001	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12880	12880	T	C	MI.20415	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	544	182	F	L	Ttc/Ctc	-10.14	0	0.06	benign	0.12	neutral	0.84	neutral	5.52	neutral	3.15	deleterious	-4.33	neutral_impact	-0.66	0.81	neutral	0.88	neutral	1.36	12.57	neutral	0.49	0.55	0.49	neutral	0.29	neutral	0.32	neutral	0.41	neutral	2	0.07	neutral	0.86	deleterious	-6	neutral	0.68	deleterious	0.08	medium_impact	0.63	medium_impact	-1.81	low_impact	0.64	0.8	4.48	9.53	0.32	N	0.48	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12881	12881	T	A	MI.20416	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	545	182	F	Y	tTc/tAc	-0.04	0	0	probably_damaging	0.92	neutral	1	neutral	4.49	deleterious	-4.09	deleterious	-2.64	high_impact	3.56	0.68	neutral	0.46	neutral	4.15	23.80	deleterious	0.24	0.45	0.75	disease	0.84	disease	0.6	disease	0.75	disease	5	0.92	neutral	0.54	deleterious	2	deleterious	0.82	deleterious	-1.75	low_impact	1.89	high_impact	2.05	high_impact	0.71	0.85	4.48	9.53	0.23	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12881	12881	T	G	MI.20417	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	545	182	F	C	tTc/tGc	-0.04	0	0	probably_damaging	0.99	neutral	0.2	neutral	4.49	deleterious	-4.86	deleterious	-6.79	high_impact	3.91	0.66	neutral	0.45	neutral	4.06	23.70	deleterious	0.24	0.45	0.91	disease	0.91	disease	0.62	disease	0.81	disease	6	0.99	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-2.64	low_impact	-0.1	medium_impact	2.37	high_impact	0.46	0.8	4.48	9.53	0.36	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12881	12881	T	C	MI.20418	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	545	182	F	S	tTc/tCc	-0.04	0	0	probably_damaging	0.97	neutral	0.56	neutral	4.49	deleterious	-4.21	deleterious	-6.95	medium_impact	3.36	0.68	neutral	0.48	neutral	4.22	23.90	deleterious	0.24	0.45	0.79	disease	0.86	disease	0.6	disease	0.76	disease	5	0.97	neutral	0.3	neutral	1	deleterious	0.83	deleterious	-2.18	low_impact	0.29	medium_impact	1.87	medium_impact	0.50	0.8	4.48	9.53	0.28	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12882	12882	C	A	MI.20419	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	546	182	F	L	ttC/ttA	7.3	0.95	0.12	benign	0.12	neutral	0.84	neutral	5.52	neutral	3.15	deleterious	-4.33	neutral_impact	-0.66	0.81	neutral	0.88	neutral	1.93	15.78	deleterious	0.49	0.55	0.49	neutral	0.29	neutral	0.32	neutral	0.41	neutral	2	0.07	neutral	0.86	deleterious	-6	neutral	0.68	deleterious	0.08	medium_impact	0.63	medium_impact	-1.81	low_impact	0.64	0.8	4.48	9.53	0.45	N	0.48	polymorphism	1	0.07	rs386420001	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5980	5980	C	G	MI.2042	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	77	26	A	G	gCt/gGt	9.38	1	0	probably_damaging	0.99	deleterious	0.01	neutral	2.66	neutral	-2.59	neutral	-1.44	medium_impact	2.46	0.59	damaging	0.54	neutral	3.74	23.30	deleterious	0.29	0.55	0.46	neutral	0.68	disease	0.3	neutral	0.52	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-2.64	low_impact	-0.92	medium_impact	1.17	medium_impact	0.76	0.9	2.14	7.08	0.55	P	0.56	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12882	12882	C	G	MI.20420	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	546	182	F	L	ttC/ttG	7.3	0.95	0.12	benign	0.12	neutral	0.84	neutral	5.52	neutral	3.15	deleterious	-4.33	neutral_impact	-0.66	0.81	neutral	0.88	neutral	1.60	13.84	neutral	0.49	0.55	0.49	neutral	0.29	neutral	0.32	neutral	0.41	neutral	2	0.07	neutral	0.86	deleterious	-6	neutral	0.68	deleterious	0.08	medium_impact	0.63	medium_impact	-1.81	low_impact	0.64	0.8	4.48	9.53	0.45	N	0.48	polymorphism	1	0.07	rs386420001	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12883	12883	A	G	MI.20421	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	547	183	I	V	Atc/Gtc	-9.91	0	0	benign	0.05	neutral	0.5	neutral	4.6	neutral	-0.59	neutral	-0.5	low_impact	1.45	0.89	neutral	0.96	neutral	-0.04	2.22	deleterious	0.48	0.55	0.5	neutral	0.51	disease	0.35	neutral	0.44	neutral	1	0.45	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.47	medium_impact	0.23	medium_impact	0.12	medium_impact	0.59	0.8	18.57	15.73	0.27	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12883	12883	A	T	MI.20422	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	547	183	I	F	Atc/Ttc	-9.91	0	0	probably_damaging	0.93	neutral	0.7	neutral	4.65	neutral	0.06	deleterious	-3.86	low_impact	1.82	0.77	neutral	0.53	neutral	3.49	23.10	deleterious	0.33	0.5	0.6	disease	0.89	disease	0.49	neutral	0.66	disease	3	0.92	neutral	0.39	neutral	-2	neutral	0.71	deleterious	-1.81	low_impact	0.44	medium_impact	0.46	medium_impact	0.73	0.85	18.57	15.73	0.17	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12883	12883	A	C	MI.20423	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	547	183	I	L	Atc/Ctc	-9.91	0	0	benign	0.39	neutral	0.65	neutral	5.7	neutral	3.69	neutral	-1.81	neutral_impact	-0.54	0.81	neutral	0.93	neutral	0.80	9.47	deleterious	0.28	0.45	0.59	disease	0.65	disease	0.41	neutral	0.48	neutral	0	0.32	neutral	0.63	deleterious	-6	neutral	0.21	neutral	-0.56	medium_impact	0.38	medium_impact	-1.7	low_impact	0.58	0.8	18.57	15.73	0.29	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12884	12884	T	A	MI.20424	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	548	183	I	N	aTc/aAc	-0.27	0	0	probably_damaging	0.96	neutral	0.31	neutral	4.51	deleterious	-4.57	deleterious	-6.58	high_impact	3.94	0.69	neutral	0.42	neutral	4.37	24.10	deleterious	0.23	0.45	0.9	disease	0.92	disease	0.57	disease	0.78	disease	6	0.97	neutral	0.18	neutral	2	deleterious	0.81	deleterious	-2.06	low_impact	0.04	medium_impact	2.4	high_impact	0.55	0.8	18.57	15.73	0.38	N	0.87	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12884	12884	T	G	MI.20425	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	548	183	I	S	aTc/aGc	-0.27	0	0	probably_damaging	0.9	neutral	0.4	neutral	4.52	deleterious	-3.4	deleterious	-5.59	medium_impact	2.8	0.68	neutral	0.47	neutral	3.96	23.60	deleterious	0.24	0.45	0.72	disease	0.89	disease	0.58	disease	0.65	disease	3	0.9	neutral	0.25	neutral	1	deleterious	0.64	deleterious	-1.65	low_impact	0.14	medium_impact	1.36	medium_impact	0.47	0.8	18.57	15.73	0.27	N	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12884	12884	T	C	MI.20426	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	548	183	I	T	aTc/aCc	-0.27	0	0	possibly_damaging	0.75	neutral	0.39	neutral	4.53	neutral	-2.74	deleterious	-4.36	medium_impact	3.05	0.73	neutral	0.45	neutral	1.75	14.68	neutral	0.44	0.55	0.68	disease	0.82	disease	0.58	disease	0.68	disease	4	0.77	neutral	0.32	neutral	0	NA	0.54	deleterious	-1.2	low_impact	0.13	medium_impact	1.58	medium_impact	0.54	0.8	18.57	15.73	0.28	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12885	12885	C	A	MI.20427	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	549	183	I	M	atC/atA	5.69	0.86	0	probably_damaging	0.93	neutral	0.22	neutral	4.62	neutral	-0.26	deleterious	-2.57	low_impact	1.6	0.78	neutral	0.9	neutral	2.53	19.64	deleterious	0.38	0.5	0.58	disease	0.68	disease	0.32	neutral	0.49	neutral	0	0.95	neutral	0.15	neutral	-2	neutral	0.64	deleterious	-1.81	low_impact	-0.07	medium_impact	0.26	medium_impact	0.74	0.85	18.57	15.73	0.39	N	0.23	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12885	12885	C	G	MI.20428	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	549	183	I	M	atC/atG	5.69	0.86	0	probably_damaging	0.93	neutral	0.22	neutral	4.62	neutral	-0.26	deleterious	-2.57	low_impact	1.6	0.78	neutral	0.9	neutral	2.05	16.54	deleterious	0.38	0.5	0.58	disease	0.68	disease	0.32	neutral	0.49	neutral	0	0.95	neutral	0.15	neutral	-2	neutral	0.64	deleterious	-1.81	low_impact	-0.07	medium_impact	0.26	medium_impact	0.74	0.85	18.57	15.73	0.39	N	0.23	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12886	12886	C	G	MI.20429	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	550	184	L	V	Ctc/Gtc	-3.94	0	0	probably_damaging	0.94	neutral	0.58	neutral	4.51	neutral	-1.69	neutral	-2.12	low_impact	1.19	0.79	neutral	0.66	neutral	3.33	22.90	deleterious	0.33	0.5	0.68	disease	0.72	disease	0.44	neutral	0.54	disease	1	0.94	neutral	0.32	neutral	-2	neutral	0.76	deleterious	-1.88	low_impact	0.31	medium_impact	-0.12	medium_impact	0.54	0.8	7.63	12.53	0.19	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5982	5982	G	C	MI.2043	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	79	27	G	R	Gga/Cga	-9.82	0	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.45	deleterious	-3.48	high_impact	4.4	0.59	damaging	0.03	damaging	3.81	23.40	deleterious	0.12	0.55	0.61	disease	0.92	disease	0.72	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.96	high_impact	0.75	0.9	4.68	7.56	0.4	N	0.95	polymorphism	0.72	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12886	12886	C	T	MI.20430	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	550	184	L	F	Ctc/Ttc	-3.94	0	0	probably_damaging	0.99	neutral	0.78	neutral	4.6	neutral	-2.33	deleterious	-3.36	low_impact	1.82	0.73	neutral	0.41	neutral	2.78	21.30	deleterious	0.34	0.5	0.61	disease	0.64	disease	0.32	neutral	0.49	neutral	0	0.99	deleterious	0.4	neutral	-2	neutral	0.76	deleterious	-2.64	low_impact	0.54	medium_impact	0.46	medium_impact	0.58	0.8	7.63	12.53	0.19	N	0.84	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12886	12886	C	A	MI.20431	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	550	184	L	I	Ctc/Atc	-3.94	0	0	probably_damaging	0.96	neutral	0.6	neutral	4.49	neutral	-1.44	neutral	-1.4	neutral_impact	0.78	0.77	neutral	0.54	neutral	3.99	23.60	deleterious	0.33	0.5	0.54	disease	0.68	disease	0.29	neutral	0.5	neutral	0	0.95	neutral	0.32	neutral	-2	neutral	0.75	deleterious	-2.06	low_impact	0.33	medium_impact	-0.49	medium_impact	0.77	0.85	7.63	12.53	0.2	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12887	12887	T	A	MI.20432	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	551	184	L	H	cTc/cAc	-5.09	0	0	probably_damaging	1	neutral	0.54	neutral	4.36	deleterious	-5.93	deleterious	-6.02	high_impact	4.25	0.73	neutral	0.13	damaging	4.14	23.80	deleterious	0.16	0.45	0.9	disease	0.88	disease	0.64	disease	0.79	disease	6	0.99	deleterious	0.27	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.27	medium_impact	2.68	high_impact	0.67	0.85	7.63	12.53	0.3	N	0.86	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12887	12887	T	C	MI.20433	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	551	184	L	P	cTc/cCc	-5.09	0	0	probably_damaging	0.99	neutral	0.22	neutral	4.36	deleterious	-5.37	deleterious	-5.95	high_impact	3.7	0.64	neutral	0.12	damaging	3.89	23.50	deleterious	0.2	0.45	0.92	disease	0.93	disease	0.67	disease	0.82	disease	6	0.99	deleterious	0.12	neutral	2	deleterious	0.90	deleterious	-2.64	low_impact	-0.07	medium_impact	2.18	high_impact	0.68	0.85	7.63	12.53	0.27	N	0.91	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12887	12887	T	G	MI.20434	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	551	184	L	R	cTc/cGc	-5.09	0	0	probably_damaging	0.98	neutral	0.34	neutral	4.37	deleterious	-5.75	deleterious	-5.12	high_impact	4.25	0.68	neutral	0.11	damaging	4.18	23.80	deleterious	0.13	0.4	0.93	disease	0.94	disease	0.68	disease	0.82	disease	6	0.99	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-2.35	low_impact	0.07	medium_impact	2.68	high_impact	0.58	0.8	7.63	12.53	0.34	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12889	12889	G	T	MI.20435	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	553	185	A	S	Gcc/Tcc	-2.34	0	0	possibly_damaging	0.86	neutral	0.61	neutral	4.51	neutral	-2.65	neutral	0.28	neutral_impact	0.64	0.84	neutral	0.98	neutral	0.88	9.95	deleterious	0.3	0.45	0.58	disease	0.3	neutral	0.25	neutral	0.61	disease	2	0.83	neutral	0.38	neutral	-3	neutral	0.47	deleterious	-1.5	low_impact	0.34	medium_impact	-0.62	medium_impact	0.77	0.85	11.61	11.79	0.35	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12889	12889	G	A	MI.20436	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	553	185	A	T	Gcc/Acc	-2.34	0	0	benign	0.15	neutral	0.41	neutral	4.45	deleterious	-3.66	neutral	-0.97	low_impact	1.81	0.88	neutral	0.97	neutral	0.57	7.97	deleterious	0.29	0.45	0.52	disease	0.47	neutral	0.29	neutral	0.47	neutral	1	0.51	neutral	0.63	deleterious	-6	neutral	0.20	neutral	-0.03	medium_impact	0.15	medium_impact	0.45	medium_impact	0.69	0.85	11.61	11.79	0.43	N	0.22	polymorphism	1	0.03	.	Uncertain_significance	not_specified	433753	MedGen:CN169374	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12889	12889	G	C	MI.20437	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	553	185	A	P	Gcc/Ccc	-2.34	0	0	probably_damaging	0.98	neutral	0.16	neutral	4.4	deleterious	-5.55	deleterious	-2.99	high_impact	4	0.67	neutral	0.31	neutral	3.71	23.30	deleterious	0.15	0.4	0.93	disease	0.94	disease	0.67	disease	0.83	disease	7	0.99	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	-0.17	medium_impact	2.45	high_impact	0.70	0.85	11.61	11.79	0.35	N	0.90	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12890	12890	C	T	MI.20438	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	554	185	A	V	gCc/gTc	-2.11	0	0	possibly_damaging	0.86	neutral	0.5	neutral	4.5	neutral	-2.65	deleterious	-2.82	medium_impact	2.25	0.83	neutral	0.64	neutral	4.09	23.70	deleterious	0.35	0.5	0.66	disease	0.82	disease	0.55	disease	0.68	disease	4	0.84	neutral	0.32	neutral	0	NA	0.60	deleterious	-1.5	low_impact	0.23	medium_impact	0.85	medium_impact	0.61	0.8	11.61	11.79	0.24	N	0.48	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12890	12890	C	A	MI.20439	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	554	185	A	D	gCc/gAc	-2.11	0	0	probably_damaging	0.98	neutral	0.13	neutral	4.41	deleterious	-6.3	deleterious	-2.97	high_impact	4	0.73	neutral	0.37	neutral	4.45	24.20	deleterious	0.14	0.4	0.94	disease	0.92	disease	0.67	disease	0.84	disease	7	0.99	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-2.35	low_impact	-0.22	medium_impact	2.45	high_impact	0.58	0.8	11.61	11.79	0.37	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5982	5982	G	T	MI.2044	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	79	27	G	W	Gga/Tga	-9.82	0	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.72	deleterious	-3.62	high_impact	4.4	0.55	damaging	0.03	damaging	4.27	23.90	deleterious	0.18	0.55	0.82	disease	0.93	disease	0.65	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.96	high_impact	0.46	0.9	4.68	7.56	0.36	N	0.83	polymorphism	0.61	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12890	12890	C	G	MI.20440	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	554	185	A	G	gCc/gGc	-2.11	0	0	possibly_damaging	0.89	neutral	0.34	neutral	4.66	neutral	0.47	neutral	-2.31	neutral_impact	0.76	0.73	neutral	0.66	neutral	3.61	23.20	deleterious	0.31	0.45	0.43	neutral	0.63	disease	0.51	disease	0.46	neutral	1	0.9	neutral	0.23	neutral	-3	neutral	0.51	deleterious	-1.61	low_impact	0.07	medium_impact	-0.51	medium_impact	0.74	0.85	11.61	11.79	0.29	N	0.52	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12892	12892	T	G	MI.20441	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	556	186	L	V	Tta/Gta	-8.53	0	0.01	possibly_damaging	0.62	neutral	0.58	neutral	4.63	neutral	-1.25	neutral	-1.07	low_impact	1.22	0.72	neutral	0.75	neutral	3.36	22.90	deleterious	0.42	0.55	0.55	disease	0.68	disease	0.45	neutral	0.51	disease	0	0.57	neutral	0.48	deleterious	-3	neutral	0.73	deleterious	-0.95	medium_impact	0.31	medium_impact	-0.09	medium_impact	0.66	0.8	5.64	10.67	0.26	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12892	12892	T	A	MI.20442	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	556	186	L	M	Tta/Ata	-8.53	0	0.01	benign	0.21	neutral	0.35	neutral	4.59	neutral	-1.31	neutral	2.75	neutral_impact	0.23	0.79	neutral	0.94	neutral	0.85	9.76	deleterious	0.33	0.5	0.46	neutral	0.04	neutral	0.21	neutral	0.25	neutral	5	0.58	neutral	0.57	deleterious	-6	neutral	0.66	deleterious	-0.2	medium_impact	0.08	medium_impact	-0.99	medium_impact	0.71	0.85	5.64	10.67	0.41	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12893	12893	T	C	MI.20443	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	557	186	L	S	tTa/tCa	2.94	0.98	0	possibly_damaging	0.9	neutral	0.5	neutral	4.53	deleterious	-3.87	deleterious	-3.09	medium_impact	2.65	0.69	neutral	0.66	neutral	3.70	23.30	deleterious	0.3	0.45	0.7	disease	0.73	disease	0.56	disease	0.7	disease	4	0.89	neutral	0.3	neutral	0	NA	0.79	deleterious	-1.65	low_impact	0.23	medium_impact	1.22	medium_impact	0.73	0.85	5.64	10.67	0.46	N	0.64	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12893	12893	T	G	MI.20444	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	557	186	L	W	tTa/tGa	2.94	0.98	0	probably_damaging	0.98	neutral	0.28	neutral	4.47	deleterious	-6.26	deleterious	-3.1	high_impact	3.89	0.67	neutral	0.48	neutral	3.71	23.30	deleterious	0.14	0.4	0.95	disease	0.85	disease	0.59	disease	0.86	disease	7	0.99	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	0.01	medium_impact	2.35	high_impact	0.52	0.8	5.64	10.67	0.52	P	0.70	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12894	12894	A	C	MI.20445	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	558	186	L	F	ttA/ttC	7.3	1	0	possibly_damaging	0.87	neutral	0.74	neutral	4.59	neutral	-1.8	neutral	-2.06	low_impact	0.9	0.7	neutral	0.83	neutral	3.45	23.00	deleterious	0.4	0.5	0.47	neutral	0.77	disease	0.54	disease	0.54	disease	1	0.84	neutral	0.44	neutral	-3	neutral	0.75	deleterious	-1.53	low_impact	0.48	medium_impact	-0.38	medium_impact	0.64	0.8	5.64	10.67	0.48	N	0.32	polymorphism	0.52	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12894	12894	A	T	MI.20446	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	558	186	L	F	ttA/ttT	7.3	1	0	possibly_damaging	0.87	neutral	0.74	neutral	4.59	neutral	-1.8	neutral	-2.06	low_impact	0.9	0.7	neutral	0.83	neutral	3.55	23.10	deleterious	0.4	0.5	0.47	neutral	0.77	disease	0.54	disease	0.54	disease	1	0.84	neutral	0.44	neutral	-3	neutral	0.75	deleterious	-1.53	low_impact	0.48	medium_impact	-0.38	medium_impact	0.64	0.8	5.64	10.67	0.48	N	0.32	polymorphism	0.52	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12895	12895	G	C	MI.20447	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	559	187	A	P	Gca/Cca	1.56	0.9	0	probably_damaging	0.95	neutral	0.3	neutral	4.54	deleterious	-4.86	deleterious	-4.2	medium_impact	2.95	0.66	neutral	0.29	neutral	3.75	23.30	deleterious	0.17	0.45	0.94	disease	0.93	disease	0.72	disease	0.84	disease	7	0.96	neutral	0.18	neutral	1	deleterious	0.85	deleterious	-1.96	low_impact	0.03	medium_impact	1.49	medium_impact	0.86	0.9	10.61	10.41	0.33	N	0.95	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12895	12895	G	A	MI.20448	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	559	187	A	T	Gca/Aca	1.56	0.9	0	benign	0.09	neutral	0.59	neutral	4.58	neutral	-2.57	deleterious	-2.52	low_impact	1.32	0.79	neutral	0.71	neutral	1.10	11.24	neutral	0.54	0.6	0.79	disease	0.77	disease	0.42	neutral	0.63	disease	3	0.32	neutral	0.75	deleterious	-6	neutral	0.28	neutral	0.21	medium_impact	0.32	medium_impact	0	medium_impact	0.69	0.85	10.61	10.41	0.23	N	0.54	disease_causing	1	0.06	.	.	.	.	.	.	COSM1636857	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12895	12895	G	T	MI.20449	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	559	187	A	S	Gca/Tca	1.56	0.9	0	possibly_damaging	0.64	neutral	0.84	neutral	4.76	neutral	-1.73	neutral	-2.35	neutral_impact	0.49	0.67	neutral	0.65	neutral	3.26	22.80	deleterious	0.5	0.6	0.5	neutral	0.75	disease	0.42	neutral	0.52	disease	0	0.58	neutral	0.6	deleterious	-3	neutral	0.54	deleterious	-0.98	medium_impact	0.63	medium_impact	-0.76	medium_impact	0.88	0.9	10.61	10.41	0.26	N	0.52	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5983	5983	G	T	MI.2045	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	80	27	G	V	gGa/gTa	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.81	neutral	0.07	deleterious	-3.88	high_impact	4.4	0.59	damaging	0.03	damaging	3.58	23.20	deleterious	0.18	0.55	0.39	neutral	0.87	disease	0.61	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.96	high_impact	0.56	0.9	4.68	7.56	0.45	N	0.93	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12896	12896	C	T	MI.20450	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	560	187	A	V	gCa/gTa	0.41	0.49	0	benign	0.13	neutral	0.59	neutral	4.65	neutral	-0.96	deleterious	-2.88	neutral_impact	0.48	0.84	neutral	0.65	neutral	3.91	23.50	deleterious	0.59	0.65	0.58	disease	0.82	disease	0.44	neutral	0.54	disease	1	0.31	neutral	0.73	deleterious	-6	neutral	0.58	deleterious	0.04	medium_impact	0.32	medium_impact	-0.76	medium_impact	0.72	0.85	10.61	10.41	0.22	N	0.46	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12896	12896	C	G	MI.20451	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	560	187	A	G	gCa/gGa	0.41	0.49	0	possibly_damaging	0.72	neutral	0.46	neutral	4.56	neutral	-1.04	deleterious	-3.61	low_impact	1.18	0.71	neutral	0.51	neutral	3.54	23.10	deleterious	0.44	0.55	0.65	disease	0.77	disease	0.59	disease	0.57	disease	1	0.71	neutral	0.37	neutral	-3	neutral	0.59	deleterious	-1.14	low_impact	0.19	medium_impact	-0.13	medium_impact	0.80	0.85	10.61	10.41	0.23	N	0.65	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12896	12896	C	A	MI.20452	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	560	187	A	E	gCa/gAa	0.41	0.49	0	possibly_damaging	0.82	neutral	0.58	neutral	4.54	deleterious	-5.01	deleterious	-4.2	high_impact	3.64	0.73	neutral	0.39	neutral	4.34	24.00	deleterious	0.16	0.45	0.92	disease	0.92	disease	0.71	disease	0.83	disease	7	0.79	neutral	0.38	neutral	1	deleterious	0.77	deleterious	-1.37	low_impact	0.31	medium_impact	2.12	high_impact	0.75	0.85	10.61	10.41	0.31	N	0.91	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12898	12898	T	G	MI.20453	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	562	188	W	G	Tga/Gga	-4.4	0	0	probably_damaging	0.95	neutral	0.35	neutral	4.64	neutral	0.27	deleterious	-12.85	low_impact	1.9	0.69	neutral	0.42	neutral	3.87	23.50	deleterious	0.49	0.55	0.4	neutral	0.87	disease	0.75	disease	0.67	disease	3	0.96	neutral	0.2	neutral	-2	neutral	0.74	deleterious	-1.96	low_impact	0.08	medium_impact	0.53	medium_impact	0.37	0.8	3.48	7.41	0.4	N	0.97	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12898	12898	T	C	MI.20454	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	562	188	W	R	Tga/Cga	-4.4	0	0	probably_damaging	0.98	neutral	0.36	neutral	4.57	neutral	-2.35	deleterious	-13.84	high_impact	4	0.66	neutral	0.26	damaging	3.49	23.10	deleterious	0.46	0.55	0.89	disease	0.94	disease	0.78	disease	0.89	disease	8	0.98	neutral	0.19	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	0.1	medium_impact	2.45	high_impact	0.20	0.8	3.48	7.41	0.47	N	0.97	disease_causing	0.98	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12899	12899	G	T	MI.20455	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	563	188	W	L	tGa/tTa	5.69	1	0	possibly_damaging	0.88	neutral	0.68	neutral	4.78	neutral	1.94	deleterious	-12.85	neutral_impact	0.36	0.69	neutral	0.44	neutral	4.19	23.80	deleterious	0.44	0.55	0.39	neutral	0.88	disease	0.74	disease	0.65	disease	3	0.86	neutral	0.4	neutral	-3	neutral	0.76	deleterious	-1.57	low_impact	0.41	medium_impact	-0.87	medium_impact	0.23	0.8	3.48	7.41	0.44	N	0.97	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12899	12899	G	C	MI.20456	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	563	188	W	S	tGa/tCa	5.69	1	0	probably_damaging	0.97	neutral	0.44	neutral	4.61	neutral	-1.21	deleterious	-13.84	medium_impact	2.25	0.72	neutral	0.4	neutral	3.96	23.60	deleterious	0.37	0.5	0.65	disease	0.92	disease	0.74	disease	0.8	disease	6	0.97	neutral	0.24	neutral	1	deleterious	0.83	deleterious	-2.18	low_impact	0.18	medium_impact	0.85	medium_impact	0.26	0.8	3.48	7.41	0.46	N	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12900	12900	A	C	MI.20457	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	564	188	W	C	tgA/tgC	5.92	1	0	probably_damaging	0.99	neutral	0.18	neutral	4.56	neutral	-2.29	deleterious	-12.85	medium_impact	2.96	0.69	neutral	0.37	neutral	3.98	23.60	deleterious	0.33	0.5	0.91	disease	0.92	disease	0.75	disease	0.81	disease	6	0.99	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-2.64	low_impact	-0.13	medium_impact	1.5	medium_impact	0.21	0.8	3.48	7.41	0.46	N	0.98	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12900	12900	A	T	MI.20458	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	564	188	W	C	tgA/tgT	5.92	1	0	probably_damaging	0.99	neutral	0.18	neutral	4.56	neutral	-2.29	deleterious	-12.85	medium_impact	2.96	0.69	neutral	0.37	neutral	4.03	23.60	deleterious	0.33	0.5	0.91	disease	0.92	disease	0.75	disease	0.81	disease	6	0.99	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-2.64	low_impact	-0.13	medium_impact	1.5	medium_impact	0.21	0.8	3.48	7.41	0.47	N	0.98	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12901	12901	T	A	MI.20459	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	565	189	F	I	Ttt/Att	0.64	0.61	0	possibly_damaging	0.52	neutral	0.44	neutral	4.84	neutral	-0.28	deleterious	-5.56	neutral_impact	-0.02	0.78	neutral	0.7	neutral	1.39	12.73	neutral	0.35	0.5	0.4	neutral	0.61	disease	0.35	neutral	0.48	neutral	0	0.56	neutral	0.46	neutral	-3	neutral	0.35	neutral	-0.78	medium_impact	0.18	medium_impact	-1.22	low_impact	0.63	0.8	16.25	15.98	0.25	N	0.91	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5983	5983	G	C	MI.2046	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	80	27	G	A	gGa/gCa	9.38	1	0	probably_damaging	1	neutral	0.05	neutral	2.77	neutral	-0.56	neutral	-2.37	low_impact	1.55	0.46	damaging	0.1	damaging	1.70	14.41	neutral	0.41	0.55	0.41	neutral	0.54	disease	0.36	neutral	0.46	neutral	1	1	deleterious	0.03	neutral	-2	neutral	0.75	deleterious	-3.58	low_impact	-0.52	medium_impact	0.33	medium_impact	0.69	0.9	4.68	7.56	0.57	P	0.64	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12901	12901	T	G	MI.20460	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	565	189	F	V	Ttt/Gtt	0.64	0.61	0	possibly_damaging	0.64	neutral	0.53	neutral	4.71	neutral	-0.7	deleterious	-6.53	neutral_impact	0.34	0.83	neutral	0.56	neutral	2.45	19.13	deleterious	0.36	0.5	0.45	neutral	0.7	disease	0.46	neutral	0.53	disease	1	0.61	neutral	0.45	neutral	-3	neutral	0.38	neutral	-0.98	medium_impact	0.26	medium_impact	-0.89	medium_impact	0.66	0.8	16.25	15.98	0.19	N	0.94	polymorphism	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12901	12901	T	C	MI.20461	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	565	189	F	L	Ttt/Ctt	0.64	0.61	0	benign	0.05	neutral	0.83	neutral	4.89	neutral	1.19	deleterious	-5.49	neutral_impact	-1.66	0.83	neutral	0.9	neutral	0.44	6.97	deleterious	0.44	0.55	0.57	disease	0.29	neutral	0.3	neutral	0.58	disease	2	0.09	neutral	0.89	deleterious	-6	neutral	0.13	neutral	0.47	medium_impact	0.61	medium_impact	-2.72	low_impact	0.64	0.8	16.25	15.98	0.24	N	0.64	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12902	12902	T	A	MI.20462	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	566	189	F	Y	tTt/tAt	-0.04	0.57	0	possibly_damaging	0.89	neutral	1	neutral	4.61	neutral	-1.35	deleterious	-2.85	low_impact	1.94	0.87	neutral	0.49	neutral	4.01	23.60	deleterious	0.36	0.5	0.72	disease	0.67	disease	0.48	neutral	0.51	disease	0	0.89	neutral	0.56	deleterious	-3	neutral	0.63	deleterious	-1.61	low_impact	1.89	high_impact	0.57	medium_impact	0.68	0.85	16.25	15.98	0.22	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12902	12902	T	C	MI.20463	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	566	189	F	S	tTt/tCt	-0.04	0.57	0	benign	0.22	neutral	0.51	neutral	4.61	neutral	-2.19	deleterious	-7.5	neutral_impact	0.3	0.82	neutral	0.63	neutral	4.11	23.70	deleterious	0.38	0.5	0.66	disease	0.66	disease	0.55	disease	0.56	disease	1	0.39	neutral	0.65	deleterious	-6	neutral	0.66	deleterious	-0.22	medium_impact	0.24	medium_impact	-0.93	medium_impact	0.61	0.8	16.25	15.98	0.24	N	0.97	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12902	12902	T	G	MI.20464	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	566	189	F	C	tTt/tGt	-0.04	0.57	0	probably_damaging	0.98	neutral	0.17	neutral	4.57	deleterious	-3.79	deleterious	-7.53	neutral_impact	0.38	0.78	neutral	0.48	neutral	4.03	23.60	deleterious	0.33	0.5	0.79	disease	0.81	disease	0.49	neutral	0.73	disease	5	0.99	deleterious	0.1	neutral	-2	neutral	0.75	deleterious	-2.35	low_impact	-0.15	medium_impact	-0.86	medium_impact	0.38	0.8	16.25	15.98	0.26	N	0.98	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12903	12903	T	G	MI.20465	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	567	189	F	L	ttT/ttG	3.63	0.72	0	benign	0.05	neutral	0.83	neutral	4.89	neutral	1.19	deleterious	-5.49	neutral_impact	-1.66	0.83	neutral	0.9	neutral	0.63	8.36	deleterious	0.44	0.55	0.57	disease	0.29	neutral	0.3	neutral	0.58	disease	2	0.09	neutral	0.89	deleterious	-6	neutral	0.13	neutral	0.47	medium_impact	0.61	medium_impact	-2.72	low_impact	0.64	0.8	16.25	15.98	0.28	N	0.64	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12903	12903	T	A	MI.20466	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	567	189	F	L	ttT/ttA	3.63	0.72	0	benign	0.05	neutral	0.83	neutral	4.89	neutral	1.19	deleterious	-5.49	neutral_impact	-1.66	0.83	neutral	0.9	neutral	0.74	9.09	deleterious	0.44	0.55	0.57	disease	0.29	neutral	0.3	neutral	0.58	disease	2	0.09	neutral	0.89	deleterious	-6	neutral	0.13	neutral	0.47	medium_impact	0.61	medium_impact	-2.72	low_impact	0.64	0.8	16.25	15.98	0.27	N	0.64	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12904	12904	A	G	MI.20467	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	568	190	I	V	Atc/Gtc	-10.83	0	0	benign	0.12	neutral	0.55	neutral	4.64	neutral	-0.02	neutral	-0.62	neutral_impact	0.55	0.73	neutral	0.79	neutral	-1.01	0.02	neutral	0.76	0.8	0.48	neutral	0.17	neutral	0.25	neutral	0.3	neutral	4	0.36	neutral	0.72	deleterious	-6	neutral	0.12	neutral	0.08	medium_impact	0.28	medium_impact	-0.7	medium_impact	0.63	0.8	31.84	19.67	0.37	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12904	12904	A	T	MI.20468	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	568	190	I	F	Atc/Ttc	-10.83	0	0	benign	0.01	neutral	0.71	neutral	4.72	neutral	0.79	neutral	-1.45	neutral_impact	0.1	0.83	neutral	0.83	neutral	0.22	4.88	deleterious	0.57	0.65	0.35	neutral	0.52	disease	0.27	neutral	0.44	neutral	1	0.28	neutral	0.85	deleterious	-6	neutral	0.15	neutral	1.15	medium_impact	0.45	medium_impact	-1.11	low_impact	0.77	0.85	31.84	19.67	0.26	N	0.12	polymorphism	1	0.03	rs386829168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12904	12904	A	C	MI.20469	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	568	190	I	L	Atc/Ctc	-10.83	0	0	benign	0.01	neutral	0.78	neutral	4.81	neutral	1.44	neutral	1.15	neutral_impact	-0.26	0.89	neutral	0.94	neutral	-0.90	0.03	neutral	0.4	0.5	0.35	neutral	0.18	neutral	0.21	neutral	0.31	neutral	4	0.2	neutral	0.89	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	0.54	medium_impact	-1.44	low_impact	0.77	0.85	31.84	19.67	0.42	N	0.03	polymorphism	1	0.01	rs386829168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5983	5983	G	A	MI.2047	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	80	27	G	E	gGa/gAa	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.68	deleterious	-3.46	high_impact	4.75	0.56	damaging	0.03	damaging	3.67	23.20	deleterious	0.2	0.55	0.58	disease	0.89	disease	0.71	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.57	0.9	4.68	7.56	0.69	P	0.93	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12905	12905	T	G	MI.20470	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	569	190	I	S	aTc/aGc	-3.26	0	0	possibly_damaging	0.49	neutral	0.51	neutral	4.6	neutral	-0.77	deleterious	-2.64	low_impact	1.04	0.83	neutral	0.95	neutral	1.01	10.74	neutral	0.5	0.6	0.42	neutral	0.48	neutral	0.28	neutral	0.46	neutral	1	0.49	neutral	0.51	deleterious	-3	neutral	0.20	neutral	-0.73	medium_impact	0.24	medium_impact	-0.25	medium_impact	0.56	0.8	31.84	19.67	0.29	N	0.11	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12905	12905	T	A	MI.20471	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	569	190	I	N	aTc/aAc	-3.26	0	0	possibly_damaging	0.8	neutral	0.35	neutral	4.56	neutral	-2.5	deleterious	-3.78	low_impact	1.7	0.73	neutral	0.55	neutral	1.41	12.84	neutral	0.4	0.5	0.83	disease	0.72	disease	0.46	neutral	0.61	disease	2	0.82	neutral	0.28	neutral	-3	neutral	0.44	deleterious	-1.32	low_impact	0.08	medium_impact	0.35	medium_impact	0.63	0.8	31.84	19.67	0.29	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12905	12905	T	C	MI.20472	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	569	190	I	T	aTc/aCc	-3.26	0	0	benign	0.41	neutral	0.54	neutral	4.59	neutral	-0.93	neutral	-1.8	low_impact	1.25	0.84	neutral	0.92	neutral	-0.03	2.26	deleterious	0.67	0.7	0.35	neutral	0.33	neutral	0.27	neutral	0.47	neutral	1	0.41	neutral	0.57	deleterious	-6	neutral	0.13	neutral	-0.6	medium_impact	0.27	medium_impact	-0.06	medium_impact	0.74	0.85	31.84	19.67	0.28	N	0.11	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12906	12906	C	G	MI.20473	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	570	190	I	M	atC/atG	0.18	0	0	benign	0.38	neutral	0.3	neutral	4.6	neutral	-0.72	neutral	0.19	low_impact	1.22	0.83	neutral	0.95	neutral	-0.08	1.88	neutral	0.66	0.7	0.7	disease	0.22	neutral	0.21	neutral	0.51	disease	0	0.65	neutral	0.46	neutral	-6	neutral	0.19	neutral	-0.54	medium_impact	0.03	medium_impact	-0.09	medium_impact	0.84	0.9	31.84	19.67	0.44	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12906	12906	C	A	MI.20474	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	570	190	I	M	atC/atA	0.18	0	0	benign	0.38	neutral	0.3	neutral	4.6	neutral	-0.72	neutral	0.19	low_impact	1.22	0.83	neutral	0.95	neutral	0.39	6.54	deleterious	0.66	0.7	0.7	disease	0.22	neutral	0.21	neutral	0.51	disease	0	0.65	neutral	0.46	neutral	-6	neutral	0.19	neutral	-0.54	medium_impact	0.03	medium_impact	-0.09	medium_impact	0.84	0.9	31.84	19.67	0.45	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12907	12907	C	A	MI.20475	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	571	191	L	M	Cta/Ata	-6.24	0	0	probably_damaging	0.98	neutral	0.62	neutral	4.56	neutral	-2.68	neutral	-0.36	neutral_impact	0.19	0.83	neutral	0.96	neutral	0.88	9.94	deleterious	0.35	0.5	0.69	disease	0.06	neutral	0.19	neutral	0.38	neutral	2	0.98	deleterious	0.32	neutral	-2	neutral	0.64	deleterious	-2.35	low_impact	0.35	medium_impact	-1.03	low_impact	0.68	0.85	20.07	15.51	0.4	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12907	12907	C	G	MI.20476	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	571	191	L	V	Cta/Gta	-6.24	0	0	possibly_damaging	0.86	neutral	0.6	neutral	4.64	neutral	-1.36	neutral	-0.78	neutral_impact	0.34	0.86	neutral	0.95	neutral	1.75	14.69	neutral	0.45	0.55	0.41	neutral	0.29	neutral	0.29	neutral	0.45	neutral	1	0.83	neutral	0.37	neutral	-3	neutral	0.47	deleterious	-1.5	low_impact	0.33	medium_impact	-0.89	medium_impact	0.42	0.8	20.07	15.51	0.27	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12908	12908	T	A	MI.20477	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	572	191	L	Q	cTa/cAa	-2.57	0	0	probably_damaging	0.99	neutral	0.36	neutral	4.54	deleterious	-3.43	deleterious	-3.18	low_impact	1.45	0.78	neutral	0.64	neutral	3.94	23.50	deleterious	0.3	0.45	0.66	disease	0.57	disease	0.54	disease	0.63	disease	3	0.99	deleterious	0.19	neutral	-2	neutral	0.71	deleterious	-2.64	low_impact	0.1	medium_impact	0.12	medium_impact	0.50	0.8	20.07	15.51	0.26	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12908	12908	T	C	MI.20478	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	572	191	L	P	cTa/cCa	-2.57	0	0	probably_damaging	0.99	neutral	0.27	neutral	4.52	deleterious	-4.76	deleterious	-3.91	low_impact	1.8	0.58	damaging	0.46	neutral	3.79	23.40	deleterious	0.25	0.45	0.81	disease	0.84	disease	0.69	disease	0.8	disease	6	0.99	deleterious	0.14	neutral	-2	neutral	0.82	deleterious	-2.64	low_impact	-0.01	medium_impact	0.44	medium_impact	0.50	0.8	20.07	15.51	0.25	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12908	12908	T	G	MI.20479	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	572	191	L	R	cTa/cGa	-2.57	0	0	probably_damaging	0.98	neutral	0.38	neutral	4.56	deleterious	-3.91	deleterious	-3.37	low_impact	1.67	0.74	neutral	0.52	neutral	4.05	23.70	deleterious	0.3	0.45	0.74	disease	0.8	disease	0.59	disease	0.76	disease	5	0.98	deleterious	0.2	neutral	-2	neutral	0.79	deleterious	-2.35	low_impact	0.12	medium_impact	0.32	medium_impact	0.50	0.8	20.07	15.51	0.25	N	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5985	5985	G	T	MI.2048	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	82	28	V	F	Gtc/Ttc	-8.66	0	0	benign	0.14	neutral	0.18	neutral	2.68	neutral	-1.41	neutral	-0.54	neutral_impact	-0.07	0.59	damaging	0.6	neutral	1.86	15.32	deleterious	0.3	0.55	0.32	neutral	0.83	disease	0.22	neutral	0.51	disease	0	0.79	neutral	0.52	deleterious	-6	neutral	0.27	neutral	-0.01	medium_impact	-0.17	medium_impact	-1.16	low_impact	0.73	0.9	14.81	54.58	0.42	N	0.48	polymorphism	1	0.01	rs386828982	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12910	12910	C	A	MI.20480	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	574	192	H	N	Cac/Aac	-12.66	0	0	benign	0.08	neutral	0.43	neutral	4.69	neutral	1.32	neutral	-0.72	neutral_impact	-1.29	0.77	neutral	0.97	neutral	1.15	11.48	neutral	0.7	0.75	0.38	neutral	0.19	neutral	0.34	neutral	0.34	neutral	3	0.51	neutral	0.68	deleterious	-6	neutral	0.68	deleterious	0.26	medium_impact	0.17	medium_impact	-2.38	low_impact	0.69	0.85	21.72	16.21	0.38	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12910	12910	C	G	MI.20481	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	574	192	H	D	Cac/Gac	-12.66	0	0	possibly_damaging	0.77	neutral	0.2	neutral	4.63	neutral	-0.74	deleterious	-3.68	neutral_impact	0.58	0.75	neutral	0.61	neutral	3.84	23.40	deleterious	0.41	0.5	0.64	disease	0.74	disease	0.75	disease	0.79	disease	6	0.87	neutral	0.22	neutral	-3	neutral	0.81	deleterious	-1.24	low_impact	-0.1	medium_impact	-0.67	medium_impact	0.62	0.8	21.72	16.21	0.34	N	0.71	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12910	12910	C	T	MI.20482	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	574	192	H	Y	Cac/Tac	-12.66	0	0	benign	0.05	neutral	1	neutral	4.69	neutral	1.26	neutral	-2.47	neutral_impact	-0.26	0.88	neutral	0.87	neutral	2.51	19.51	deleterious	0.73	0.75	0.58	disease	0.63	disease	0.44	neutral	0.5	neutral	0	0.05	neutral	0.98	deleterious	-6	neutral	0.78	deleterious	0.47	medium_impact	1.89	high_impact	-1.44	low_impact	0.33	0.8	21.72	16.21	0.24	N	0.33	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12911	12911	A	G	MI.20483	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	575	192	H	R	cAc/cGc	-0.27	0	0	possibly_damaging	0.82	neutral	0.34	neutral	4.64	neutral	-0.08	deleterious	-3.65	low_impact	1.22	0.8	neutral	0.65	neutral	2.79	21.30	deleterious	0.68	0.7	0.59	disease	0.75	disease	0.7	disease	0.76	disease	5	0.84	neutral	0.26	neutral	-3	neutral	0.81	deleterious	-1.37	low_impact	0.07	medium_impact	-0.09	medium_impact	0.36	0.8	21.72	16.21	0.25	N	0.67	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12911	12911	A	T	MI.20484	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	575	192	H	L	cAc/cTc	-0.27	0	0	possibly_damaging	0.66	neutral	0.9	neutral	4.85	neutral	2.97	deleterious	-5.89	neutral_impact	-0.06	0.81	neutral	0.64	neutral	3.65	23.20	deleterious	0.48	0.55	0.4	neutral	0.74	disease	0.65	disease	0.7	disease	4	0.61	neutral	0.62	deleterious	-3	neutral	0.74	deleterious	-1.02	low_impact	0.76	medium_impact	-1.26	low_impact	0.29	0.8	21.72	16.21	0.24	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12911	12911	A	C	MI.20485	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	575	192	H	P	cAc/cCc	-0.27	0	0	probably_damaging	0.97	neutral	0.26	neutral	4.63	neutral	-0.94	deleterious	-5.42	low_impact	1.34	0.7	neutral	0.48	neutral	3.12	22.60	deleterious	0.4	0.5	0.83	disease	0.9	disease	0.78	disease	0.85	disease	7	0.97	neutral	0.15	neutral	-2	neutral	0.89	deleterious	-2.18	low_impact	-0.02	medium_impact	0.02	medium_impact	0.36	0.8	21.72	16.21	0.3	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12912	12912	C	G	MI.20486	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	576	192	H	Q	caC/caG	3.63	0.07	0	probably_damaging	0.91	neutral	0.32	neutral	4.66	neutral	0.66	deleterious	-3.44	neutral_impact	0.06	0.83	neutral	0.81	neutral	3.54	23.10	deleterious	0.74	0.75	0.59	disease	0.52	disease	0.59	disease	0.65	disease	3	0.92	neutral	0.21	neutral	-2	neutral	0.75	deleterious	-1.7	low_impact	0.05	medium_impact	-1.15	low_impact	0.62	0.8	21.72	16.21	0.33	N	0.64	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12912	12912	C	A	MI.20487	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	576	192	H	Q	caC/caA	3.63	0.07	0	probably_damaging	0.91	neutral	0.32	neutral	4.66	neutral	0.66	deleterious	-3.44	neutral_impact	0.06	0.83	neutral	0.81	neutral	3.76	23.30	deleterious	0.74	0.75	0.59	disease	0.52	disease	0.59	disease	0.65	disease	3	0.92	neutral	0.21	neutral	-2	neutral	0.75	deleterious	-1.7	low_impact	0.05	medium_impact	-1.15	low_impact	0.62	0.8	21.72	16.21	0.33	N	0.64	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12913	12913	T	G	MI.20488	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	577	193	S	A	Tcc/Gcc	-0.73	0	0	benign	0.02	neutral	0.96	neutral	4.6	neutral	0.11	neutral	-1.16	neutral_impact	0.54	0.84	neutral	0.87	neutral	0.50	7.46	deleterious	0.52	0.6	0.37	neutral	0.32	neutral	0.41	neutral	0.46	neutral	1	0.01	neutral	0.97	deleterious	-6	neutral	0.13	neutral	0.86	medium_impact	1	medium_impact	-0.71	medium_impact	0.73	0.85	32.34	19.26	0.25	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12913	12913	T	A	MI.20489	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	577	193	S	T	Tcc/Acc	-0.73	0	0	benign	0.02	neutral	0.66	neutral	4.76	neutral	0.85	neutral	-0.72	neutral_impact	-0.37	0.9	neutral	0.99	neutral	0.57	7.91	deleterious	0.48	0.55	0.37	neutral	0.22	neutral	0.23	neutral	0.35	neutral	3	0.31	neutral	0.82	deleterious	-6	neutral	0.11	neutral	0.86	medium_impact	0.39	medium_impact	-1.54	low_impact	0.86	0.9	32.34	19.26	0.39	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5985	5985	G	C	MI.2049	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	82	28	V	L	Gtc/Ctc	-8.66	0	0	benign	0.01	neutral	0.32	neutral	2.86	neutral	-0.03	neutral	0.68	neutral_impact	-1.01	0.66	neutral	0.77	neutral	-0.06	2.08	deleterious	0.4	0.55	0.16	neutral	0.39	neutral	0.16	neutral	0.44	neutral	1	0.67	neutral	0.66	deleterious	-6	neutral	0.14	neutral	1.12	medium_impact	0.01	medium_impact	-2.03	low_impact	0.61	0.9	14.81	54.58	0.53	N	0.27	polymorphism	1	0.01	rs386828982	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12913	12913	T	C	MI.20490	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	577	193	S	P	Tcc/Ccc	-0.73	0	0	possibly_damaging	0.66	neutral	0.33	neutral	4.51	deleterious	-3.71	deleterious	-2.95	medium_impact	2.31	0.59	damaging	0.41	neutral	2.64	20.50	deleterious	0.25	0.45	0.9	disease	0.85	disease	0.54	disease	0.78	disease	6	0.73	neutral	0.34	neutral	0	NA	0.72	deleterious	-1.02	low_impact	0.06	medium_impact	0.91	medium_impact	0.68	0.85	32.34	19.26	0.29	N	0.65	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12914	12914	C	T	MI.20491	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	578	193	S	F	tCc/tTc	-5.78	0	0	benign	0.38	neutral	0.74	neutral	4.53	neutral	-1.7	neutral	-1.92	neutral_impact	-0.98	0.81	neutral	0.84	neutral	2.67	20.60	deleterious	0.45	0.55	0.59	disease	0.6	disease	0.35	neutral	0.48	neutral	0	0.27	neutral	0.68	deleterious	-6	neutral	0.69	deleterious	-0.54	medium_impact	0.48	medium_impact	-2.1	low_impact	0.35	0.8	32.34	19.26	0.21	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12914	12914	C	G	MI.20492	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	578	193	S	C	tCc/tGc	-5.78	0	0	possibly_damaging	0.9	neutral	0.2	neutral	4.51	deleterious	-4.82	neutral	-2.05	low_impact	1.06	0.86	neutral	0.67	neutral	2.38	18.66	deleterious	0.34	0.5	0.85	disease	0.66	disease	0.43	neutral	0.6	disease	2	0.94	neutral	0.15	neutral	-3	neutral	0.71	deleterious	-1.65	low_impact	-0.1	medium_impact	-0.23	medium_impact	0.66	0.8	32.34	19.26	0.32	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12914	12914	C	A	MI.20493	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	578	193	S	Y	tCc/tAc	-5.78	0	0	benign	0.01	neutral	1	neutral	4.53	neutral	-2.2	neutral	-2.1	neutral_impact	0.18	0.9	neutral	0.82	neutral	2.41	18.86	deleterious	0.34	0.5	0.54	disease	0.65	disease	0.37	neutral	0.47	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.69	deleterious	1.15	medium_impact	1.89	high_impact	-1.04	low_impact	0.68	0.85	32.34	19.26	0.19	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12916	12916	A	G	MI.20494	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	580	194	N	D	Aac/Gac	-6.7	0	0	probably_damaging	1	neutral	0.35	neutral	4.56	neutral	-1.28	deleterious	-4.65	low_impact	1.08	0.72	neutral	0.14	damaging	3.84	23.40	deleterious	0.62	0.65	0.64	disease	0.67	disease	0.6	disease	0.6	disease	2	1	deleterious	0.18	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.08	medium_impact	-0.22	medium_impact	0.65	0.8	5.14	7.18	0.23	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12916	12916	A	C	MI.20495	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	580	194	N	H	Aac/Cac	-6.7	0	0	probably_damaging	1	neutral	0.56	neutral	4.55	neutral	-2.12	deleterious	-4.72	low_impact	1.62	0.7	neutral	0.12	damaging	3.08	22.50	deleterious	0.44	0.55	0.85	disease	0.71	disease	0.63	disease	0.72	disease	4	1	deleterious	0.28	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.29	medium_impact	0.28	medium_impact	0.51	0.8	5.14	7.18	0.17	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12916	12916	A	T	MI.20496	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	580	194	N	Y	Aac/Tac	-6.7	0	0	probably_damaging	1	neutral	1	neutral	4.54	deleterious	-3.04	deleterious	-7.53	medium_impact	2.48	0.74	neutral	0.1	damaging	3.74	23.30	deleterious	0.29	0.45	0.82	disease	0.82	disease	0.62	disease	0.71	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.83	deleterious	-3.6	low_impact	1.89	high_impact	1.06	medium_impact	0.46	0.8	5.14	7.18	0.17	N	0.99	polymorphism	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12917	12917	A	G	MI.20497	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	581	194	N	S	aAc/aGc	6.61	1	0	probably_damaging	1	neutral	0.59	neutral	4.74	neutral	-0.66	deleterious	-4.38	neutral_impact	0.21	0.73	neutral	0.22	damaging	3.11	22.50	deleterious	0.61	0.65	0.71	disease	0.52	disease	0.46	neutral	0.48	neutral	0	1	deleterious	0.3	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.32	medium_impact	-1.01	low_impact	0.32	0.8	5.14	7.18	0.42	N	0.82	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12917	12917	A	C	MI.20498	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	581	194	N	T	aAc/aCc	6.61	1	0	probably_damaging	1	neutral	0.55	neutral	4.57	neutral	-0.3	deleterious	-5.49	medium_impact	2.02	0.7	neutral	0.15	damaging	3.42	23.00	deleterious	0.44	0.55	0.75	disease	0.66	disease	0.65	disease	0.55	disease	1	1	deleterious	0.28	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.28	medium_impact	0.64	medium_impact	0.44	0.8	5.14	7.18	0.42	N	0.94	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12917	12917	A	T	MI.20499	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	581	194	N	I	aAc/aTc	6.61	1	0	probably_damaging	1	neutral	0.45	neutral	4.53	neutral	-2.53	deleterious	-8.43	medium_impact	3.04	0.71	neutral	0.1	damaging	3.98	23.60	deleterious	0.29	0.45	0.86	disease	0.88	disease	0.63	disease	0.76	disease	5	1	deleterious	0.23	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.18	medium_impact	1.57	medium_impact	0.39	0.8	5.14	7.18	0.51	N	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8621	8621	C	G	MI.205	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	95	32	P	R	cCc/cGc	0.13	0	0	probably_damaging	1	neutral	0.05	neutral	4.45	neutral	1.6	deleterious	-7.15	medium_impact	3.12	0.86	neutral	0.14	damaging	3.39	23.00	deleterious	0.4	0.65	0.41	neutral	0.86	disease	0.55	disease	0.67	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.43	medium_impact	1.58	medium_impact	0.59	0.9	29.2	19.38	0.32	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5985	5985	G	A	MI.2050	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	82	28	V	I	Gtc/Atc	-8.66	0	0	benign	0	deleterious	0.01	neutral	2.72	neutral	-0.45	neutral	0.1	neutral_impact	0.06	0.66	neutral	0.73	neutral	1.44	12.98	neutral	0.58	0.65	0.27	neutral	0.32	neutral	0.21	neutral	0.45	neutral	1	0.99	deleterious	0.51	deleterious	-2	neutral	0.15	neutral	2.07	high_impact	-0.92	medium_impact	-1.04	low_impact	0.81	0.9	14.81	54.58	0.54	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12918	12918	C	G	MI.20500	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	582	194	N	K	aaC/aaG	4.54	1	0	probably_damaging	1	neutral	0.51	neutral	4.6	neutral	-0.96	deleterious	-5.57	low_impact	1.91	0.7	neutral	0.11	damaging	3.97	23.60	deleterious	0.59	0.65	0.63	disease	0.75	disease	0.69	disease	0.63	disease	3	1	deleterious	0.26	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.24	medium_impact	0.54	medium_impact	0.72	0.85	5.14	7.18	0.34	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12918	12918	C	A	MI.20501	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	582	194	N	K	aaC/aaA	4.54	1	0	probably_damaging	1	neutral	0.51	neutral	4.6	neutral	-0.96	deleterious	-5.57	low_impact	1.91	0.7	neutral	0.11	damaging	4.39	24.10	deleterious	0.59	0.65	0.63	disease	0.75	disease	0.69	disease	0.63	disease	3	1	deleterious	0.26	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.24	medium_impact	0.54	medium_impact	0.72	0.85	5.14	7.18	0.35	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12919	12919	T	C	MI.20502	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	583	195	S	P	Tca/Cca	-0.04	0	0	probably_damaging	1	neutral	0.28	neutral	4.34	deleterious	-4.66	deleterious	-4.08	high_impact	4	0.59	damaging	0.17	damaging	4.04	23.70	deleterious	0.28	0.45	0.92	disease	0.9	disease	0.72	disease	0.83	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.01	medium_impact	2.45	high_impact	0.46	0.8	13.6	17.03	0.36	N	0.95	disease_causing	0.91	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12919	12919	T	G	MI.20503	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	583	195	S	A	Tca/Gca	-0.04	0	0	probably_damaging	1	neutral	0.82	neutral	4.41	neutral	-1.84	neutral	-2.1	medium_impact	2.61	0.81	neutral	0.94	neutral	3.65	23.20	deleterious	0.42	0.55	0.61	disease	0.57	disease	0.63	disease	0.51	disease	0	1	deleterious	0.41	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.6	medium_impact	1.18	medium_impact	0.72	0.85	13.6	17.03	0.23	N	0.43	polymorphism	0.68	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12919	12919	T	A	MI.20504	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	583	195	S	T	Tca/Aca	-0.04	0	0	probably_damaging	1	neutral	0.58	neutral	4.49	neutral	-0.24	neutral	-1.33	neutral_impact	0.5	0.78	neutral	0.95	neutral	2.57	19.90	deleterious	0.39	0.5	0.43	neutral	0.32	neutral	0.38	neutral	0.43	neutral	1	1	deleterious	0.29	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.31	medium_impact	-0.75	medium_impact	0.71	0.85	13.6	17.03	0.27	N	0.06	disease_causing	0.61	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12920	12920	C	T	MI.20505	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	584	195	S	L	tCa/tTa	-1.65	0	0	probably_damaging	1	neutral	0.78	neutral	4.39	neutral	-2.75	deleterious	-4.78	medium_impact	2.92	0.7	neutral	0.19	damaging	4.66	24.50	deleterious	0.25	0.45	0.86	disease	0.87	disease	0.72	disease	0.78	disease	6	1	deleterious	0.39	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.54	medium_impact	1.46	medium_impact	0.80	0.85	13.6	17.03	0.21	N	0.86	disease_causing	0.94	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12920	12920	C	G	MI.20506	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	584	195	S	W	tCa/tGa	-1.65	0	0	probably_damaging	1	neutral	0.22	neutral	4.32	deleterious	-7.54	deleterious	-5.84	high_impact	4.2	0.71	neutral	0.18	damaging	4.35	24.10	deleterious	0.25	0.45	0.98	disease	0.91	disease	0.76	disease	0.86	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.07	medium_impact	2.63	high_impact	0.44	0.8	13.6	17.03	0.35	N	0.98	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12922	12922	T	G	MI.20507	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	586	196	W	G	Tga/Gga	-2.11	0	0	probably_damaging	1	neutral	0.38	neutral	4.54	neutral	-0.23	deleterious	-12.82	high_impact	3.67	0.63	neutral	0.44	neutral	3.91	23.50	deleterious	0.4	0.5	0.84	disease	0.83	disease	0.84	disease	0.77	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.12	medium_impact	2.15	high_impact	0.21	0.8	15.26	7.04	0.46	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12922	12922	T	C	MI.20508	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	586	196	W	R	Tga/Cga	-2.11	0	0	probably_damaging	1	neutral	0.39	neutral	4.54	neutral	-2.41	deleterious	-13.81	high_impact	4.01	0.63	neutral	0.31	neutral	3.54	23.10	deleterious	0.43	0.55	0.82	disease	0.92	disease	0.87	disease	0.82	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.13	medium_impact	2.46	high_impact	0.24	0.8	15.26	7.04	0.47	N	0.97	disease_causing	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12923	12923	G	T	MI.20509	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	587	196	W	L	tGa/tTa	4.54	1	0	probably_damaging	1	neutral	0.75	neutral	4.86	neutral	1.83	deleterious	-12.82	low_impact	0.92	0.64	neutral	0.57	neutral	4.19	23.80	deleterious	0.4	0.5	0.57	disease	0.78	disease	0.79	disease	0.62	disease	2	1	deleterious	0.38	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.5	medium_impact	-0.36	medium_impact	0.21	0.8	15.26	7.04	0.42	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5986	5986	T	C	MI.2051	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	83	28	V	A	gTc/gCc	4.06	0.99	0	benign	0	deleterious	0.02	neutral	2.77	neutral	0.54	neutral	-1.02	low_impact	1.3	0.61	neutral	0.81	neutral	1.51	13.35	neutral	0.39	0.55	0.31	neutral	0.5	neutral	0.45	neutral	0.5	neutral	0	0.98	neutral	0.51	deleterious	-2	neutral	0.19	neutral	2.07	high_impact	-0.75	medium_impact	0.1	medium_impact	0.44	0.9	14.81	54.58	0.58	P	0.28	polymorphism	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12923	12923	G	C	MI.20510	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	587	196	W	S	tGa/tCa	4.54	1	0	probably_damaging	1	neutral	0.64	neutral	4.56	neutral	-1.01	deleterious	-13.81	medium_impact	2.77	0.65	neutral	0.42	neutral	4.01	23.60	deleterious	0.37	0.5	0.74	disease	0.9	disease	0.82	disease	0.81	disease	6	1	deleterious	0.32	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.37	medium_impact	1.33	medium_impact	0.23	0.8	15.26	7.04	0.43	N	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12924	12924	A	C	MI.20511	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	588	196	W	C	tgA/tgC	4.08	1	0	probably_damaging	1	neutral	0.18	neutral	4.56	deleterious	-3.21	deleterious	-12.82	high_impact	4.36	0.65	neutral	0.28	damaging	4.05	23.70	deleterious	0.33	0.5	0.46	neutral	0.91	disease	0.83	disease	0.8	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	-0.13	medium_impact	2.78	high_impact	0.18	0.8	15.26	7.04	0.56	P	0.98	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12924	12924	A	T	MI.20512	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	588	196	W	C	tgA/tgT	4.08	1	0	probably_damaging	1	neutral	0.18	neutral	4.56	deleterious	-3.21	deleterious	-12.82	high_impact	4.36	0.65	neutral	0.28	damaging	4.12	23.80	deleterious	0.33	0.5	0.46	neutral	0.91	disease	0.83	disease	0.8	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	-0.13	medium_impact	2.78	high_impact	0.18	0.8	15.26	7.04	0.57	P	0.98	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12925	12925	G	C	MI.20513	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	589	197	D	H	Gac/Cac	0.18	0.98	0	probably_damaging	0.98	neutral	0.57	neutral	4.56	deleterious	-3.8	deleterious	-4.1	low_impact	1.82	0.76	neutral	0.46	neutral	3.59	23.20	deleterious	0.47	0.55	0.68	disease	0.77	disease	0.67	disease	0.73	disease	5	0.97	neutral	0.3	neutral	-2	neutral	0.75	deleterious	-2.35	low_impact	0.3	medium_impact	0.46	medium_impact	0.55	0.8	4.48	9.19	0.33	N	0.71	polymorphism	0.68	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12925	12925	G	A	MI.20514	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	589	197	D	N	Gac/Aac	0.18	0.98	0	benign	0.17	neutral	0.46	neutral	4.68	neutral	-1.12	deleterious	-3.03	neutral_impact	-0.42	0.8	neutral	0.85	neutral	2.58	19.98	deleterious	0.82	0.85	0.53	disease	0.66	disease	0.43	neutral	0.48	neutral	0	0.45	neutral	0.65	deleterious	-6	neutral	0.56	deleterious	-0.09	medium_impact	0.19	medium_impact	-1.59	low_impact	0.78	0.85	4.48	9.19	0.32	N	0.47	polymorphism	0.92	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12925	12925	G	T	MI.20515	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	589	197	D	Y	Gac/Tac	0.18	0.98	0	probably_damaging	0.98	neutral	1	neutral	4.55	deleterious	-4.72	deleterious	-6.11	medium_impact	3.21	0.74	neutral	0.48	neutral	3.88	23.50	deleterious	0.43	0.55	0.76	disease	0.89	disease	0.67	disease	0.78	disease	6	0.98	deleterious	0.51	deleterious	1	deleterious	0.82	deleterious	-2.35	low_impact	1.89	high_impact	1.73	medium_impact	0.30	0.8	4.48	9.19	0.33	N	0.97	polymorphism	0.5	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12926	12926	A	G	MI.20516	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	590	197	D	G	gAc/gGc	5	1	0	possibly_damaging	0.74	neutral	0.43	neutral	4.55	neutral	-2.33	deleterious	-5.15	medium_impact	2.01	0.75	neutral	0.59	neutral	3.55	23.10	deleterious	0.4	0.5	0.24	neutral	0.75	disease	0.64	disease	0.66	disease	3	0.74	neutral	0.35	neutral	0	NA	0.49	deleterious	-1.18	low_impact	0.17	medium_impact	0.63	medium_impact	0.38	0.8	4.48	9.19	0.5	N	0.85	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12926	12926	A	T	MI.20517	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	590	197	D	V	gAc/gTc	5	1	0	probably_damaging	0.96	neutral	0.58	neutral	4.54	deleterious	-3.84	deleterious	-6.14	medium_impact	2.52	0.78	neutral	0.57	neutral	3.47	23.00	deleterious	0.45	0.55	0.62	disease	0.83	disease	0.64	disease	0.75	disease	5	0.95	neutral	0.31	neutral	1	deleterious	0.68	deleterious	-2.06	low_impact	0.31	medium_impact	1.1	medium_impact	0.33	0.8	4.48	9.19	0.39	N	0.95	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12926	12926	A	C	MI.20518	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	590	197	D	A	gAc/gCc	5	1	0	possibly_damaging	0.83	neutral	0.71	neutral	4.58	neutral	-2.11	deleterious	-5.15	medium_impact	2.4	0.76	neutral	0.65	neutral	1.94	15.80	deleterious	0.5	0.6	0.47	neutral	0.74	disease	0.65	disease	0.66	disease	3	0.8	neutral	0.44	neutral	0	NA	0.50	deleterious	-1.4	low_impact	0.45	medium_impact	0.99	medium_impact	0.55	0.8	4.48	9.19	0.45	N	0.83	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12927	12927	C	G	MI.20519	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	591	197	D	E	gaC/gaG	5.46	1	0	benign	0.08	neutral	0.55	neutral	4.66	neutral	-1.28	neutral	-0.28	neutral_impact	0.17	0.85	neutral	0.97	neutral	-0.79	0.04	neutral	0.72	0.75	0.27	neutral	0.2	neutral	0.16	neutral	0.38	neutral	2	0.37	neutral	0.74	deleterious	-6	neutral	0.13	neutral	0.26	medium_impact	0.28	medium_impact	-1.05	low_impact	0.59	0.8	4.48	9.19	0.53	P	0.14	disease_causing	0.97	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5986	5986	T	A	MI.2052	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	83	28	V	D	gTc/gAc	4.06	0.99	0	benign	0.12	deleterious	0	neutral	2.55	neutral	-1.16	neutral	-2.17	medium_impact	2.66	0.49	damaging	0.47	neutral	2.78	21.30	deleterious	0.09	0.55	0.77	disease	0.87	disease	0.61	disease	0.8	disease	6	1	deleterious	0.44	neutral	1	deleterious	0.38	neutral	0.06	medium_impact	-1.48	low_impact	1.36	medium_impact	0.68	0.9	14.81	54.58	0.51	P	0.68	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12927	12927	C	A	MI.20520	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	591	197	D	E	gaC/gaA	5.46	1	0	benign	0.08	neutral	0.55	neutral	4.66	neutral	-1.28	neutral	-0.28	neutral_impact	0.17	0.85	neutral	0.97	neutral	-0.48	0.25	neutral	0.72	0.75	0.27	neutral	0.2	neutral	0.16	neutral	0.38	neutral	2	0.37	neutral	0.74	deleterious	-6	neutral	0.13	neutral	0.26	medium_impact	0.28	medium_impact	-1.05	low_impact	0.59	0.8	4.48	9.19	0.53	P	0.14	disease_causing	0.97	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12928	12928	C	T	MI.20521	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	592	198	P	S	Cca/Tca	-5.78	0	0	benign	0.41	neutral	0.88	neutral	4.67	neutral	1.53	neutral	1.02	neutral_impact	-0.46	0.79	neutral	0.72	neutral	3.69	23.30	deleterious	0.54	0.6	0.42	neutral	0.18	neutral	0.41	neutral	0.31	neutral	4	0.31	neutral	0.74	deleterious	-6	neutral	0.60	deleterious	-0.6	medium_impact	0.71	medium_impact	-1.62	low_impact	0.42	0.8	9.45	11.24	0.23	N	0.37	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12928	12928	C	A	MI.20522	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	592	198	P	T	Cca/Aca	-5.78	0	0	benign	0.41	neutral	0.73	neutral	4.71	neutral	2.47	neutral	1.59	neutral_impact	-0.34	0.82	neutral	0.82	neutral	3.56	23.10	deleterious	0.55	0.6	0.41	neutral	0.17	neutral	0.4	neutral	0.3	neutral	4	0.31	neutral	0.66	deleterious	-6	neutral	0.55	deleterious	-0.6	medium_impact	0.47	medium_impact	-1.51	low_impact	0.81	0.85	9.45	11.24	0.26	N	0.36	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12928	12928	C	G	MI.20523	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	592	198	P	A	Cca/Gca	-5.78	0	0	benign	0.27	neutral	0.96	neutral	4.72	neutral	2.64	neutral	1.59	neutral_impact	-0.2	0.83	neutral	0.77	neutral	2.68	20.70	deleterious	0.41	0.5	0.23	neutral	0.12	neutral	0.42	neutral	0.33	neutral	3	0.2	neutral	0.85	deleterious	-6	neutral	0.46	deleterious	-0.34	medium_impact	1	medium_impact	-1.39	low_impact	0.85	0.9	9.45	11.24	0.28	N	0.38	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12929	12929	C	T	MI.20524	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	593	198	P	L	cCa/cTa	-3.03	0	0	benign	0.01	neutral	0.71	neutral	4.89	neutral	4.29	neutral	5.12	neutral_impact	-3.6	0.87	neutral	0.97	neutral	-0.27	0.76	neutral	0.58	0.65	0.2	neutral	0.16	neutral	0.12	neutral	0.24	neutral	5	0.27	neutral	0.85	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	0.45	medium_impact	-4.49	low_impact	0.91	0.95	9.45	11.24	0.33	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12929	12929	C	G	MI.20525	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	593	198	P	R	cCa/cGa	-3.03	0	0	possibly_damaging	0.66	neutral	0.66	neutral	4.65	neutral	0.58	neutral	0.61	neutral_impact	0.34	0.75	neutral	0.47	neutral	3.49	23.10	deleterious	0.35	0.5	0.52	disease	0.43	neutral	0.6	disease	0.52	disease	0	0.6	neutral	0.5	deleterious	-3	neutral	0.70	deleterious	-1.02	low_impact	0.39	medium_impact	-0.89	medium_impact	0.75	0.85	9.45	11.24	0.27	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12929	12929	C	A	MI.20526	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	593	198	P	Q	cCa/cAa	-3.03	0	0	possibly_damaging	0.73	neutral	0.68	neutral	4.65	neutral	0.41	neutral	0.73	neutral_impact	0.34	0.79	neutral	0.59	neutral	4.00	23.60	deleterious	0.29	0.45	0.51	disease	0.25	neutral	0.46	neutral	0.32	neutral	4	0.68	neutral	0.48	deleterious	-3	neutral	0.66	deleterious	-1.16	low_impact	0.41	medium_impact	-0.89	medium_impact	0.74	0.85	9.45	11.24	0.26	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12931	12931	C	G	MI.20527	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	595	199	Q	E	Caa/Gaa	-13.12	0	0	probably_damaging	1	neutral	0.4	neutral	4.7	neutral	0.7	deleterious	-2.88	low_impact	1.07	0.77	neutral	0.18	damaging	3.09	22.50	deleterious	0.52	0.6	0.53	disease	0.63	disease	0.68	disease	0.5	neutral	0	1	deleterious	0.2	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.14	medium_impact	-0.23	medium_impact	0.66	0.8	2.99	7.87	0.24	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12931	12931	C	A	MI.20528	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	595	199	Q	K	Caa/Aaa	-13.12	0	0	probably_damaging	1	neutral	0.39	neutral	4.65	neutral	0.06	deleterious	-3.84	low_impact	1.53	0.73	neutral	0.11	damaging	3.97	23.60	deleterious	0.49	0.55	0.51	disease	0.78	disease	0.77	disease	0.73	disease	5	1	deleterious	0.2	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.13	medium_impact	0.2	medium_impact	0.50	0.8	2.99	7.87	0.27	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12932	12932	A	C	MI.20529	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	596	199	Q	P	cAa/cCa	2.02	0.95	0	probably_damaging	1	neutral	0.27	neutral	4.63	neutral	-0.27	deleterious	-5.78	medium_impact	2	0.65	neutral	0.27	damaging	3.27	22.80	deleterious	0.32	0.5	0.81	disease	0.84	disease	0.77	disease	0.71	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.01	medium_impact	0.62	medium_impact	0.55	0.8	2.99	7.87	0.36	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5986	5986	T	G	MI.2053	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	83	28	V	G	gTc/gGc	4.06	0.99	0	benign	0.06	deleterious	0	neutral	2.58	neutral	0.7	neutral	-2.18	low_impact	1.5	0.57	damaging	0.5	neutral	1.87	15.43	deleterious	0.19	0.55	0.62	disease	0.71	disease	0.5	neutral	0.54	disease	1	1	deleterious	0.47	deleterious	-2	neutral	0.27	neutral	0.37	medium_impact	-1.48	low_impact	0.29	medium_impact	0.57	0.9	14.81	54.58	0.45	N	0.54	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12932	12932	A	G	MI.20530	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	596	199	Q	R	cAa/cGa	2.02	0.95	0	probably_damaging	1	neutral	0.39	neutral	4.64	neutral	-0.05	deleterious	-3.84	low_impact	1.88	0.65	neutral	0.11	damaging	3.37	22.90	deleterious	0.62	0.65	0.52	disease	0.79	disease	0.79	disease	0.75	disease	5	1	deleterious	0.2	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.13	medium_impact	0.51	medium_impact	0.42	0.8	2.99	7.87	0.35	N	0.85	disease_causing	0.96	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12932	12932	A	T	MI.20531	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	596	199	Q	L	cAa/cTa	2.02	0.95	0	probably_damaging	1	neutral	0.7	neutral	4.66	neutral	0.19	deleterious	-6.28	neutral_impact	0.8	0.68	neutral	0.11	damaging	3.65	23.20	deleterious	0.41	0.5	0.75	disease	0.79	disease	0.69	disease	0.65	disease	3	1	deleterious	0.35	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.44	medium_impact	-0.47	medium_impact	0.39	0.8	2.99	7.87	0.28	N	0.96	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12933	12933	A	C	MI.20532	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	597	199	Q	H	caA/caC	6.84	1	0	probably_damaging	1	neutral	0.55	neutral	4.57	neutral	-1.81	deleterious	-4.8	low_impact	1.72	0.72	neutral	0.3	neutral	3.34	22.90	deleterious	0.51	0.6	0.77	disease	0.68	disease	0.56	disease	0.55	disease	1	1	deleterious	0.28	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.28	medium_impact	0.37	medium_impact	0.67	0.85	2.99	7.87	0.45	N	0.94	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12933	12933	A	T	MI.20533	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	597	199	Q	H	caA/caT	6.84	1	0	probably_damaging	1	neutral	0.55	neutral	4.57	neutral	-1.81	deleterious	-4.8	low_impact	1.72	0.72	neutral	0.3	neutral	3.54	23.10	deleterious	0.51	0.6	0.77	disease	0.68	disease	0.56	disease	0.55	disease	1	1	deleterious	0.28	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.28	medium_impact	0.37	medium_impact	0.67	0.85	2.99	7.87	0.46	N	0.94	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12934	12934	C	G	MI.20534	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	598	200	Q	E	Caa/Gaa	3.17	1	0	probably_damaging	1	neutral	0.29	neutral	4.74	neutral	0.43	deleterious	-2.93	neutral_impact	-0.8	0.69	neutral	0.31	neutral	3.03	22.30	deleterious	0.58	0.65	0.47	neutral	0.42	neutral	0.5	neutral	0.41	neutral	2	1	deleterious	0.15	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.02	medium_impact	-1.93	low_impact	0.64	0.8	11.61	14.07	0.36	N	0.83	disease_causing	0.72	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12934	12934	C	A	MI.20535	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	598	200	Q	K	Caa/Aaa	3.17	1	0	probably_damaging	1	neutral	0.3	neutral	4.71	neutral	-0.71	deleterious	-3.91	low_impact	1.92	0.7	neutral	0.13	damaging	4.04	23.70	deleterious	0.55	0.6	0.59	disease	0.69	disease	0.78	disease	0.73	disease	5	1	deleterious	0.15	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.03	medium_impact	0.55	medium_impact	0.60	0.8	11.61	14.07	0.41	N	0.81	disease_causing	0.84	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12935	12935	A	C	MI.20536	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	599	200	Q	P	cAa/cCa	2.71	1	0	probably_damaging	1	neutral	0.22	neutral	4.6	neutral	-2.9	deleterious	-5.88	low_impact	1.02	0.67	neutral	0.12	damaging	3.07	22.50	deleterious	0.13	0.4	0.84	disease	0.81	disease	0.81	disease	0.84	disease	7	1	deleterious	0.11	neutral	-2	neutral	0.86	deleterious	-3.6	low_impact	-0.07	medium_impact	-0.27	medium_impact	0.44	0.8	11.61	14.07	0.34	N	0.94	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12935	12935	A	G	MI.20537	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	599	200	Q	R	cAa/cGa	2.71	1	0	probably_damaging	1	neutral	0.35	neutral	4.64	neutral	-1.09	deleterious	-3.88	low_impact	1.69	0.66	neutral	0.12	damaging	3.15	22.60	deleterious	0.56	0.6	0.69	disease	0.7	disease	0.8	disease	0.78	disease	6	1	deleterious	0.18	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.08	medium_impact	0.34	medium_impact	0.51	0.8	11.61	14.07	0.38	N	0.70	disease_causing	0.89	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12935	12935	A	T	MI.20538	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	599	200	Q	L	cAa/cTa	2.71	1	0	probably_damaging	1	neutral	0.68	neutral	4.67	neutral	-0.75	deleterious	-6.5	neutral_impact	0.74	0.72	neutral	0.12	damaging	3.50	23.10	deleterious	0.32	0.5	0.68	disease	0.71	disease	0.67	disease	0.63	disease	3	1	deleterious	0.34	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.41	medium_impact	-0.53	medium_impact	0.28	0.8	11.61	14.07	0.29	N	0.94	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12936	12936	A	C	MI.20539	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	600	200	Q	H	caA/caC	6.84	1	0	probably_damaging	1	neutral	0.54	neutral	4.59	neutral	-1.55	deleterious	-4.88	low_impact	1.3	0.75	neutral	0.56	neutral	2.28	18.05	deleterious	0.59	0.65	0.82	disease	0.58	disease	0.49	neutral	0.57	disease	1	1	deleterious	0.27	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	0.27	medium_impact	-0.02	medium_impact	0.70	0.85	11.61	14.07	0.45	N	0.81	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5988	5988	C	G	MI.2054	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	85	29	L	V	Cta/Gta	0.59	0.98	0	benign	0	neutral	1	neutral	2.76	neutral	-0.53	neutral	0.73	neutral_impact	-0.34	0.79	neutral	0.97	neutral	-1.46	0.00	neutral	0.46	0.55	0.23	neutral	0.07	neutral	0.17	neutral	0.23	neutral	6	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	1.86	high_impact	-1.41	low_impact	0.73	0.9	13.45	58.16	0.43	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12936	12936	A	T	MI.20540	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	600	200	Q	H	caA/caT	6.84	1	0	probably_damaging	1	neutral	0.54	neutral	4.59	neutral	-1.55	deleterious	-4.88	low_impact	1.3	0.75	neutral	0.56	neutral	2.38	18.67	deleterious	0.59	0.65	0.82	disease	0.58	disease	0.49	neutral	0.57	disease	1	1	deleterious	0.27	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	0.27	medium_impact	-0.02	medium_impact	0.70	0.85	11.61	14.07	0.46	N	0.81	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12937	12937	A	T	MI.20541	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	601	201	M	L	Ata/Tta	0.18	0.06	0	benign	0.16	neutral	0.89	neutral	4.94	neutral	2.43	neutral	0.28	neutral_impact	-1.08	0.84	neutral	0.95	neutral	0.11	3.74	deleterious	0.65	0.7	0.33	neutral	0.3	neutral	0.25	neutral	0.46	neutral	1	0.07	neutral	0.87	deleterious	-6	neutral	0.14	neutral	-0.06	medium_impact	0.73	medium_impact	-2.19	low_impact	0.63	0.8	19.07	18.66	0.31	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12937	12937	A	C	MI.20542	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	601	201	M	L	Ata/Cta	0.18	0.06	0	benign	0.16	neutral	0.89	neutral	4.94	neutral	2.43	neutral	0.28	neutral_impact	-1.08	0.84	neutral	0.95	neutral	0.01	2.71	deleterious	0.65	0.7	0.33	neutral	0.3	neutral	0.25	neutral	0.46	neutral	1	0.07	neutral	0.87	deleterious	-6	neutral	0.14	neutral	-0.06	medium_impact	0.73	medium_impact	-2.19	low_impact	0.63	0.8	19.07	18.66	0.31	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12937	12937	A	G	MI.20543	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	601	201	M	V	Ata/Gta	0.18	0.06	0	benign	0.02	neutral	0.63	neutral	4.72	neutral	1.05	neutral	0.2	neutral_impact	-0.12	0.79	neutral	0.8	neutral	-0.43	0.33	neutral	0.64	0.7	0.34	neutral	0.35	neutral	0.29	neutral	0.47	neutral	1	0.34	neutral	0.81	deleterious	-6	neutral	0.12	neutral	0.86	medium_impact	0.36	medium_impact	-1.31	low_impact	0.69	0.85	19.07	18.66	0.27	N	0.02	polymorphism	1	0.00	rs201612920	.	.	.	.	.	COSM6716797	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12938	12938	T	C	MI.20544	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	602	201	M	T	aTa/aCa	0.41	0.06	0	possibly_damaging	0.56	neutral	0.5	neutral	4.65	neutral	0.19	deleterious	-2.73	neutral_impact	0.2	0.83	neutral	0.8	neutral	1.28	12.14	neutral	0.56	0.6	0.3	neutral	0.57	disease	0.48	neutral	0.48	neutral	1	0.55	neutral	0.47	deleterious	-3	neutral	0.33	neutral	-0.85	medium_impact	0.23	medium_impact	-1.02	low_impact	0.46	0.8	19.07	18.66	0.3	N	0.36	polymorphism	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12938	12938	T	A	MI.20545	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	602	201	M	K	aTa/aAa	0.41	0.06	0	possibly_damaging	0.86	neutral	0.36	neutral	4.59	neutral	-1.6	deleterious	-3.83	low_impact	1.59	0.75	neutral	0.47	neutral	2.69	20.70	deleterious	0.22	0.45	0.42	neutral	0.69	disease	0.67	disease	0.73	disease	5	0.86	neutral	0.25	neutral	-3	neutral	0.49	deleterious	-1.5	low_impact	0.1	medium_impact	0.25	medium_impact	0.48	0.8	19.07	18.66	0.33	N	0.84	polymorphism	0.88	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12939	12939	A	T	MI.20546	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	603	201	M	I	atA/atT	1.56	0.09	0	benign	0.32	neutral	0.59	neutral	4.86	neutral	2.02	neutral	0.92	neutral_impact	-1.8	0.82	neutral	0.97	neutral	-1.07	0.01	neutral	0.59	0.65	0.27	neutral	0.16	neutral	0.16	neutral	0.27	neutral	5	0.32	neutral	0.64	deleterious	-6	neutral	0.14	neutral	-0.44	medium_impact	0.32	medium_impact	-2.85	low_impact	0.70	0.85	19.07	18.66	0.38	N	0.06	polymorphism	0.88	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12939	12939	A	C	MI.20547	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	603	201	M	I	atA/atC	1.56	0.09	0	benign	0.32	neutral	0.59	neutral	4.86	neutral	2.02	neutral	0.92	neutral_impact	-1.8	0.82	neutral	0.97	neutral	-1.23	0.01	neutral	0.59	0.65	0.27	neutral	0.16	neutral	0.16	neutral	0.27	neutral	5	0.32	neutral	0.64	deleterious	-6	neutral	0.14	neutral	-0.44	medium_impact	0.32	medium_impact	-2.85	low_impact	0.70	0.85	19.07	18.66	0.39	N	0.06	polymorphism	0.88	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12940	12940	G	A	MI.20548	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	604	202	A	T	Gcc/Acc	-4.86	0	0.01	benign	0.01	neutral	0.39	neutral	4.61	neutral	-2.68	neutral	-0.1	neutral_impact	0.65	0.81	neutral	0.75	neutral	2.25	17.85	deleterious	0.57	0.65	0.41	neutral	0.29	neutral	0.26	neutral	0.46	neutral	1	0.6	neutral	0.69	deleterious	-6	neutral	0.15	neutral	1.15	medium_impact	0.13	medium_impact	-0.61	medium_impact	0.73	0.85	14.1	14.08	0.43	N	0.12	polymorphism	1	0.01	rs200106331	.	.	.	.	.	COSM488736	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12940	12940	G	C	MI.20549	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	604	202	A	P	Gcc/Ccc	-4.86	0	0.01	benign	0.29	neutral	0.23	neutral	4.55	deleterious	-4.24	neutral	-1.81	low_impact	1.19	0.67	neutral	0.6	neutral	2.01	16.25	deleterious	0.25	0.45	0.69	disease	0.72	disease	0.61	disease	0.7	disease	4	0.72	neutral	0.47	deleterious	-6	neutral	0.55	deleterious	-0.38	medium_impact	-0.06	medium_impact	-0.12	medium_impact	0.71	0.85	14.1	14.08	0.29	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5988	5988	C	A	MI.2055	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	85	29	L	M	Cta/Ata	0.59	0.98	0	benign	0	neutral	0.08	neutral	2.55	neutral	-2.67	neutral	-0.16	low_impact	0.8	0.67	neutral	0.86	neutral	0.43	6.84	deleterious	0.32	0.55	0.35	neutral	0.37	neutral	0.26	neutral	0.47	neutral	1	0.92	neutral	0.54	deleterious	-6	neutral	0.15	neutral	2.07	high_impact	-0.4	medium_impact	-0.36	medium_impact	0.68	0.9	13.45	58.16	0.58	P	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12940	12940	G	T	MI.20550	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	604	202	A	S	Gcc/Tcc	-4.86	0	0.01	benign	0.01	neutral	0.41	neutral	4.65	neutral	-1.96	neutral	-0.2	neutral_impact	0.01	0.8	neutral	0.71	neutral	1.72	14.53	neutral	0.63	0.7	0.33	neutral	0.26	neutral	0.39	neutral	0.44	neutral	1	0.58	neutral	0.7	deleterious	-6	neutral	0.15	neutral	1.15	medium_impact	0.15	medium_impact	-1.19	low_impact	0.77	0.85	14.1	14.08	0.35	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12941	12941	C	G	MI.20551	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	605	202	A	G	gCc/gGc	0.18	0	0	benign	0.11	neutral	0.33	neutral	4.58	neutral	-2.23	neutral	-1.23	low_impact	1.34	0.81	neutral	0.64	neutral	2.08	16.73	deleterious	0.5	0.6	0.62	disease	0.28	neutral	0.39	neutral	0.55	disease	1	0.62	neutral	0.61	deleterious	-6	neutral	0.26	neutral	0.12	medium_impact	0.06	medium_impact	0.02	medium_impact	0.70	0.85	14.1	14.08	0.39	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12941	12941	C	A	MI.20552	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	605	202	A	D	gCc/gAc	0.18	0	0	benign	0.17	neutral	0.2	neutral	4.59	deleterious	-3.15	neutral	-1.28	low_impact	1.28	0.74	neutral	0.65	neutral	2.76	21.20	deleterious	0.39	0.5	0.68	disease	0.63	disease	0.58	disease	0.72	disease	4	0.77	neutral	0.52	deleterious	-6	neutral	0.44	deleterious	-0.09	medium_impact	-0.1	medium_impact	-0.03	medium_impact	0.54	0.8	14.1	14.08	0.35	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12941	12941	C	T	MI.20553	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	605	202	A	V	gCc/gTc	0.18	0	0	benign	0	neutral	0.51	neutral	4.66	deleterious	-3.3	neutral	1.01	neutral_impact	0.32	0.86	neutral	0.78	neutral	2.46	19.22	deleterious	0.57	0.65	0.25	neutral	0.32	neutral	0.45	neutral	0.44	neutral	1	0.49	neutral	0.76	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.24	medium_impact	-0.91	medium_impact	0.77	0.85	14.1	14.08	0.32	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12943	12943	C	A	MI.20554	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	607	203	L	I	Ctt/Att	-4.63	0	0	benign	0.01	neutral	0.41	neutral	4.51	neutral	-2.7	neutral	0.02	neutral_impact	-0.08	0.87	neutral	0.99	neutral	1.62	13.96	neutral	0.65	0.7	0.55	disease	0.09	neutral	0.16	neutral	0.33	neutral	3	0.58	neutral	0.7	deleterious	-6	neutral	0.65	deleterious	1.15	medium_impact	0.15	medium_impact	-1.28	low_impact	0.55	0.8	18.74	11.88	0.52	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12943	12943	C	G	MI.20555	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	607	203	L	V	Ctt/Gtt	-4.63	0	0	benign	0.04	neutral	0.51	neutral	4.54	neutral	-1.39	neutral	-0.32	neutral_impact	0.74	0.85	neutral	0.93	neutral	2.09	16.82	deleterious	0.73	0.75	0.5	neutral	0.12	neutral	0.18	neutral	0.27	neutral	5	0.44	neutral	0.74	deleterious	-6	neutral	0.64	deleterious	0.57	medium_impact	0.24	medium_impact	-0.53	medium_impact	0.59	0.8	18.74	11.88	0.42	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12943	12943	C	T	MI.20556	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	607	203	L	F	Ctt/Ttt	-4.63	0	0	possibly_damaging	0.68	neutral	0.72	neutral	4.51	neutral	-2.48	neutral	-1.36	neutral_impact	0.48	0.82	neutral	0.95	neutral	2.18	17.41	deleterious	0.79	0.8	0.63	disease	0.2	neutral	0.18	neutral	0.41	neutral	2	0.61	neutral	0.52	deleterious	-3	neutral	0.68	deleterious	-1.06	low_impact	0.46	medium_impact	-0.76	medium_impact	0.50	0.8	18.74	11.88	0.32	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12944	12944	T	A	MI.20557	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	608	203	L	H	cTt/cAt	-6.47	0	0	probably_damaging	0.95	neutral	0.55	neutral	4.51	neutral	-2.61	deleterious	-3.39	low_impact	1.37	0.76	neutral	0.76	neutral	2.96	22.10	deleterious	0.38	0.5	0.78	disease	0.4	neutral	0.28	neutral	0.56	disease	1	0.95	neutral	0.3	neutral	-2	neutral	0.74	deleterious	-1.96	low_impact	0.28	medium_impact	0.05	medium_impact	0.57	0.8	18.74	11.88	0.26	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12944	12944	T	C	MI.20558	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	608	203	L	P	cTt/cCt	-6.47	0	0	possibly_damaging	0.8	neutral	0.22	neutral	4.5	neutral	-2.89	deleterious	-3.46	low_impact	0.88	0.79	neutral	0.76	neutral	3.72	23.30	deleterious	0.27	0.45	0.8	disease	0.66	disease	0.57	disease	0.68	disease	4	0.87	neutral	0.21	neutral	-3	neutral	0.81	deleterious	-1.32	low_impact	-0.07	medium_impact	-0.4	medium_impact	0.46	0.8	18.74	11.88	0.28	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12944	12944	T	G	MI.20559	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	608	203	L	R	cTt/cGt	-6.47	0	0	possibly_damaging	0.74	neutral	0.35	neutral	4.57	neutral	-0.98	deleterious	-3	low_impact	1.64	0.72	neutral	0.5	neutral	4.12	23.80	deleterious	0.35	0.5	0.68	disease	0.59	disease	0.5	neutral	0.49	neutral	0	0.78	neutral	0.31	neutral	-3	neutral	0.79	deleterious	-1.18	low_impact	0.08	medium_impact	0.3	medium_impact	0.61	0.8	18.74	11.88	0.28	N	0.45	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5989	5989	T	A	MI.2056	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	86	29	L	Q	cTa/cAa	1.75	0.98	0	benign	0.1	deleterious	0	neutral	2.51	deleterious	-3.47	neutral	-1.92	high_impact	3.66	0.63	neutral	0.62	neutral	2.04	16.49	deleterious	0.18	0.55	0.7	disease	0.7	disease	0.53	disease	0.64	disease	3	1	deleterious	0.45	neutral	2	deleterious	0.28	neutral	0.14	medium_impact	-1.48	low_impact	2.28	high_impact	0.75	0.9	13.45	58.16	0.51	N	0.47	polymorphism	0.96	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12946	12946	C	G	MI.20560	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	610	204	L	V	Cta/Gta	-13.81	0	0	probably_damaging	1	neutral	0.53	neutral	4.57	neutral	-1.69	neutral	-0.84	medium_impact	2.14	0.82	neutral	0.45	neutral	2.31	18.23	deleterious	0.68	0.7	0.44	neutral	0.21	neutral	0.38	neutral	0.39	neutral	2	1	deleterious	0.27	neutral	1	deleterious	0.67	deleterious	-3.6	low_impact	0.26	medium_impact	0.75	medium_impact	0.48	0.8	19.4	14.75	0.28	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12946	12946	C	A	MI.20561	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	610	204	L	M	Cta/Ata	-13.81	0	0	probably_damaging	1	neutral	0.24	neutral	4.53	neutral	-2.64	neutral	-0.28	low_impact	1.53	0.83	neutral	0.85	neutral	2.55	19.79	deleterious	0.45	0.55	0.63	disease	0.17	neutral	0.19	neutral	0.41	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	-0.04	medium_impact	0.2	medium_impact	0.73	0.85	19.4	14.75	0.53	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12947	12947	T	G	MI.20562	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	611	204	L	R	cTa/cGa	-3.26	0	0	probably_damaging	1	neutral	0.4	neutral	4.55	deleterious	-3.39	deleterious	-2.53	medium_impact	1.96	0.7	neutral	0.11	damaging	4.03	23.70	deleterious	0.48	0.55	0.27	neutral	0.68	disease	0.58	disease	0.69	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.14	medium_impact	0.59	medium_impact	0.57	0.8	19.4	14.75	0.21	N	0.60	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12947	12947	T	C	MI.20563	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	611	204	L	P	cTa/cCa	-3.26	0	0	probably_damaging	1	neutral	0.27	neutral	4.51	deleterious	-3.97	deleterious	-3.04	medium_impact	2.63	0.71	neutral	0.35	neutral	3.79	23.40	deleterious	0.52	0.6	0.74	disease	0.66	disease	0.69	disease	0.55	disease	1	1	deleterious	0.14	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.01	medium_impact	1.2	medium_impact	0.44	0.8	19.4	14.75	0.26	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12947	12947	T	A	MI.20564	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	611	204	L	Q	cTa/cAa	-3.26	0	0	probably_damaging	1	neutral	0.39	neutral	4.52	deleterious	-3.65	neutral	-2.31	low_impact	0.94	0.83	neutral	0.32	neutral	3.92	23.50	deleterious	0.46	0.55	0.6	disease	0.45	neutral	0.27	neutral	0.58	disease	2	1	deleterious	0.2	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.13	medium_impact	-0.34	medium_impact	0.61	0.8	19.4	14.75	0.29	N	0.57	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12949	12949	A	C	MI.20565	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	613	205	N	H	Aac/Cac	-6.24	0	0	probably_damaging	0.94	neutral	0.55	neutral	4.47	neutral	-2.81	neutral	-1.49	low_impact	1.28	0.81	neutral	0.97	neutral	1.87	15.42	deleterious	0.84	0.85	0.64	disease	0.27	neutral	0.31	neutral	0.55	disease	1	0.93	neutral	0.31	neutral	-2	neutral	0.64	deleterious	-1.88	low_impact	0.28	medium_impact	-0.03	medium_impact	0.34	0.8	10.45	11.95	0.31	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12949	12949	A	G	MI.20566	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	613	205	N	D	Aac/Gac	-6.24	0	0	benign	0.03	neutral	0.23	neutral	4.55	neutral	-0.91	neutral	-1.59	neutral_impact	0.58	0.87	neutral	0.94	neutral	0.68	8.67	deleterious	0.9	0.9	0.45	neutral	0.22	neutral	0.26	neutral	0.37	neutral	3	0.76	neutral	0.6	deleterious	-6	neutral	0.41	neutral	0.69	medium_impact	-0.06	medium_impact	-0.67	medium_impact	0.28	0.8	10.45	11.95	0.5	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12949	12949	A	T	MI.20567	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	613	205	N	Y	Aac/Tac	-6.24	0	0	probably_damaging	0.92	neutral	1	neutral	4.45	deleterious	-3.52	deleterious	-3.25	low_impact	0.86	0.83	neutral	0.75	neutral	3.56	23.10	deleterious	0.67	0.7	0.73	disease	0.32	neutral	0.3	neutral	0.63	disease	3	0.92	neutral	0.54	deleterious	-2	neutral	0.68	deleterious	-1.75	low_impact	1.89	high_impact	-0.42	medium_impact	0.41	0.8	10.45	11.95	0.22	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12950	12950	A	C	MI.20568	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	614	205	N	T	aAc/aCc	-3.26	0	0.03	possibly_damaging	0.52	neutral	0.43	neutral	4.5	neutral	-1.68	neutral	-2.4	neutral_impact	-0.2	0.87	neutral	0.98	neutral	0.26	5.33	deleterious	0.77	0.8	0.22	neutral	0.16	neutral	0.2	neutral	0.29	neutral	4	0.57	neutral	0.46	neutral	-3	neutral	0.32	neutral	-0.78	medium_impact	0.17	medium_impact	-1.39	low_impact	0.34	0.8	10.45	11.95	0.41	N	0.13	polymorphism	1	0.05	rs201361958	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	12950	12950	A	G	MI.20569	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	614	205	N	S	aAc/aGc	-3.26	0	0.03	benign	0.08	neutral	0.45	neutral	4.61	neutral	-0.25	neutral	-1.79	neutral_impact	-0.28	0.83	neutral	0.96	neutral	-1.66	0.00	neutral	0.73	0.75	0.4	neutral	0.07	neutral	0.17	neutral	0.23	neutral	6	0.49	neutral	0.69	deleterious	-6	neutral	0.11	neutral	0.26	medium_impact	0.18	medium_impact	-1.46	low_impact	0.15	0.8	10.45	11.95	0.35	N	0.01	polymorphism	1	0.02	rs201361958	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	5989	5989	T	G	MI.2057	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	86	29	L	R	cTa/cGa	1.75	0.98	0	benign	0.08	deleterious	0	neutral	2.56	deleterious	-3.42	neutral	-2.25	high_impact	3.66	0.52	damaging	0.51	neutral	2.11	16.94	deleterious	0.18	0.55	0.45	neutral	0.88	disease	0.66	disease	0.82	disease	6	1	deleterious	0.46	neutral	2	deleterious	0.30	neutral	0.24	medium_impact	-1.48	low_impact	2.28	high_impact	0.76	0.9	13.45	58.16	0.53	N	0.55	polymorphism	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12950	12950	A	T	MI.20570	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	614	205	N	I	aAc/aTc	-3.26	0	0.03	possibly_damaging	0.89	neutral	0.41	neutral	4.51	neutral	-1.54	deleterious	-4.52	neutral_impact	0.57	0.82	neutral	0.63	neutral	3.61	23.20	deleterious	0.66	0.7	0.47	neutral	0.45	neutral	0.38	neutral	0.48	neutral	0	0.89	neutral	0.26	neutral	-3	neutral	0.61	deleterious	-1.61	low_impact	0.15	medium_impact	-0.68	medium_impact	0.33	0.8	10.45	11.95	0.28	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12951	12951	C	A	MI.20571	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	615	205	N	K	aaC/aaA	-0.5	0	0	possibly_damaging	0.52	neutral	0.33	neutral	4.55	neutral	-0.94	deleterious	-2.55	low_impact	1.52	0.85	neutral	0.87	neutral	1.48	13.22	neutral	0.86	0.9	0.24	neutral	0.33	neutral	0.44	neutral	0.45	neutral	1	0.66	neutral	0.41	neutral	-3	neutral	0.41	neutral	-0.78	medium_impact	0.06	medium_impact	0.19	medium_impact	0.51	0.8	10.45	11.95	0.37	N	0.54	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12951	12951	C	G	MI.20572	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	615	205	N	K	aaC/aaG	-0.5	0	0	possibly_damaging	0.52	neutral	0.33	neutral	4.55	neutral	-0.94	deleterious	-2.55	low_impact	1.52	0.85	neutral	0.87	neutral	1.00	10.68	neutral	0.86	0.9	0.24	neutral	0.33	neutral	0.44	neutral	0.45	neutral	1	0.66	neutral	0.41	neutral	-3	neutral	0.41	neutral	-0.78	medium_impact	0.06	medium_impact	0.19	medium_impact	0.51	0.8	10.45	11.95	0.37	N	0.54	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12952	12952	G	A	MI.20573	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	616	206	A	T	Gct/Act	-11.74	0	0	benign	0	neutral	0.42	neutral	4.66	neutral	0.32	neutral	0.82	neutral_impact	-0.64	0.9	neutral	0.94	neutral	0.56	7.88	deleterious	0.7	0.75	0.39	neutral	0.15	neutral	0.24	neutral	0.29	neutral	4	0.58	neutral	0.71	deleterious	-6	neutral	0.11	neutral	2.1	high_impact	0.16	medium_impact	-1.79	low_impact	0.68	0.85	35.49	20.15	0.47	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12952	12952	G	C	MI.20574	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	616	206	A	P	Gct/Cct	-11.74	0	0	benign	0	neutral	0.23	neutral	4.58	neutral	-1.81	neutral	1.4	neutral_impact	-0.76	0.9	neutral	0.97	neutral	0.50	7.44	deleterious	0.43	0.55	0.51	disease	0.54	disease	0.26	neutral	0.45	neutral	1	0.77	neutral	0.62	deleterious	-6	neutral	0.48	deleterious	2.1	high_impact	-0.06	medium_impact	-1.9	low_impact	0.58	0.8	35.49	20.15	0.38	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12952	12952	G	T	MI.20575	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	616	206	A	S	Gct/Tct	-11.74	0	0	benign	0.01	neutral	0.45	neutral	4.75	neutral	1.24	neutral	1.06	neutral_impact	-0.52	0.91	neutral	0.92	neutral	0.07	3.29	deleterious	0.54	0.6	0.46	neutral	0.17	neutral	0.23	neutral	0.29	neutral	4	0.54	neutral	0.72	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.18	medium_impact	-1.68	low_impact	0.58	0.8	35.49	20.15	0.41	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12953	12953	C	A	MI.20576	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	617	206	A	D	gCt/gAt	-3.03	0	0	benign	0.11	neutral	0.23	neutral	4.62	neutral	-0.56	neutral	0.98	neutral_impact	-0.36	0.84	neutral	0.73	neutral	1.15	11.47	neutral	0.47	0.55	0.63	disease	0.45	neutral	0.49	neutral	0.6	disease	2	0.74	neutral	0.56	deleterious	-6	neutral	0.27	neutral	0.12	medium_impact	-0.06	medium_impact	-1.53	low_impact	0.53	0.8	35.49	20.15	0.38	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12953	12953	C	G	MI.20577	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	617	206	A	G	gCt/gGt	-3.03	0	0	benign	0.07	neutral	0.35	neutral	4.62	neutral	-0.59	neutral	-0.52	neutral_impact	-0.36	0.84	neutral	0.78	neutral	0.84	9.71	deleterious	0.6	0.65	0.38	neutral	0.17	neutral	0.38	neutral	0.3	neutral	4	0.61	neutral	0.64	deleterious	-6	neutral	0.16	neutral	0.32	medium_impact	0.08	medium_impact	-1.53	low_impact	0.74	0.85	35.49	20.15	0.39	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12953	12953	C	T	MI.20578	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	617	206	A	V	gCt/gTt	-3.03	0	0	benign	0.11	neutral	0.52	neutral	4.6	neutral	-0.89	neutral	-0.88	low_impact	0.99	0.88	neutral	0.77	neutral	1.32	12.36	neutral	0.62	0.65	0.39	neutral	0.23	neutral	0.42	neutral	0.44	neutral	1	0.39	neutral	0.71	deleterious	-6	neutral	0.20	neutral	0.12	medium_impact	0.25	medium_impact	-0.3	medium_impact	0.64	0.8	35.49	20.15	0.35	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12955	12955	A	G	MI.20579	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	619	207	N	D	Aat/Gat	-4.63	0	0	benign	0.02	neutral	0.23	neutral	4.48	neutral	-0.56	neutral	-0.88	neutral_impact	0.64	0.85	neutral	0.97	neutral	0.42	6.80	deleterious	0.74	0.75	0.57	disease	0.19	neutral	0.47	neutral	0.42	neutral	2	0.76	neutral	0.61	deleterious	-6	neutral	0.47	deleterious	0.86	medium_impact	-0.06	medium_impact	-0.62	medium_impact	0.33	0.8	16.58	10.52	0.43	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5989	5989	T	C	MI.2058	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	86	29	L	P	cTa/cCa	1.75	0.98	0	benign	0.1	deleterious	0	neutral	2.51	deleterious	-4.16	neutral	-2.06	high_impact	3.66	0.46	damaging	0.45	neutral	1.88	15.45	deleterious	0.14	0.55	0.75	disease	0.9	disease	0.68	disease	0.81	disease	6	1	deleterious	0.45	neutral	2	deleterious	0.36	neutral	0.14	medium_impact	-1.48	low_impact	2.28	high_impact	0.59	0.9	13.45	58.16	0.55	P	0.66	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12955	12955	A	T	MI.20580	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	619	207	N	Y	Aat/Tat	-4.63	0	0	benign	0.03	neutral	1	neutral	4.5	deleterious	-3.28	deleterious	-3.46	low_impact	1.68	0.84	neutral	0.73	neutral	3.59	23.20	deleterious	0.48	0.55	0.85	disease	0.48	neutral	0.54	disease	0.67	disease	3	0.03	neutral	0.99	deleterious	-6	neutral	0.73	deleterious	0.69	medium_impact	1.89	high_impact	0.33	medium_impact	0.41	0.8	16.58	10.52	0.21	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12955	12955	A	C	MI.20581	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	619	207	N	H	Aat/Cat	-4.63	0	0	benign	0.04	neutral	0.55	neutral	4.47	neutral	-1.42	neutral	-1.77	low_impact	1.5	0.84	neutral	0.82	neutral	1.83	15.16	deleterious	0.68	0.7	0.77	disease	0.43	neutral	0.41	neutral	0.65	disease	3	0.4	neutral	0.76	deleterious	-6	neutral	0.69	deleterious	0.57	medium_impact	0.28	medium_impact	0.17	medium_impact	0.41	0.8	16.58	10.52	0.26	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12956	12956	A	C	MI.20582	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	620	207	N	T	aAt/aCt	-2.57	0	0	benign	0.03	neutral	0.41	neutral	4.59	neutral	-0.81	neutral	-2.04	neutral_impact	0.57	0.86	neutral	0.96	neutral	0.48	7.31	deleterious	0.54	0.6	0.63	disease	0.23	neutral	0.28	neutral	0.54	disease	1	0.56	neutral	0.69	deleterious	-6	neutral	0.44	deleterious	0.69	medium_impact	0.15	medium_impact	-0.68	medium_impact	0.32	0.8	16.58	10.52	0.34	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12956	12956	A	G	MI.20583	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	620	207	N	S	aAt/aGt	-2.57	0	0	benign	0.03	neutral	0.44	neutral	4.57	neutral	0.04	neutral	-1.29	low_impact	1.23	0.91	neutral	0.98	neutral	0.11	3.71	deleterious	0.7	0.75	0.28	neutral	0.27	neutral	0.29	neutral	0.44	neutral	1	0.53	neutral	0.71	deleterious	-6	neutral	0.13	neutral	0.69	medium_impact	0.18	medium_impact	-0.08	medium_impact	0.09	0.8	16.58	10.52	0.41	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12956	12956	A	T	MI.20584	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	620	207	N	I	aAt/aTt	-2.57	0	0	possibly_damaging	0.59	neutral	0.41	neutral	4.56	deleterious	-3.19	deleterious	-4.17	low_impact	1.88	0.87	neutral	0.79	neutral	3.79	23.40	deleterious	0.48	0.55	0.81	disease	0.55	disease	0.46	neutral	0.55	disease	1	0.63	neutral	0.41	neutral	-3	neutral	0.70	deleterious	-0.9	medium_impact	0.15	medium_impact	0.51	medium_impact	0.37	0.8	16.58	10.52	0.35	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12957	12957	T	A	MI.20585	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	621	207	N	K	aaT/aaA	0.64	0	0.01	benign	0.27	neutral	0.31	neutral	4.51	neutral	-1.29	neutral	-0.14	low_impact	0.9	0.86	neutral	0.93	neutral	1.45	13.02	neutral	0.77	0.8	0.49	neutral	0.43	neutral	0.32	neutral	0.42	neutral	2	0.63	neutral	0.52	deleterious	-6	neutral	0.52	deleterious	-0.34	medium_impact	0.04	medium_impact	-0.38	medium_impact	0.41	0.8	16.58	10.52	0.46	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12957	12957	T	G	MI.20586	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	621	207	N	K	aaT/aaG	0.64	0	0.01	benign	0.27	neutral	0.31	neutral	4.51	neutral	-1.29	neutral	-0.14	low_impact	0.9	0.86	neutral	0.93	neutral	1.13	11.39	neutral	0.77	0.8	0.49	neutral	0.43	neutral	0.32	neutral	0.42	neutral	2	0.63	neutral	0.52	deleterious	-6	neutral	0.52	deleterious	-0.34	medium_impact	0.04	medium_impact	-0.38	medium_impact	0.41	0.8	16.58	10.52	0.46	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12958	12958	C	A	MI.20587	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	622	208	P	T	Cca/Aca	-4.86	0	0	benign	0.02	neutral	0.7	neutral	4.71	neutral	-2.54	neutral	0.83	neutral_impact	0.41	0.87	neutral	0.97	neutral	0.10	3.58	deleterious	0.56	0.6	0.26	neutral	0.11	neutral	0.19	neutral	0.29	neutral	4	0.27	neutral	0.84	deleterious	-6	neutral	0.08	neutral	0.86	medium_impact	0.44	medium_impact	-0.83	medium_impact	0.78	0.85	26.53	19.06	0.37	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12958	12958	C	T	MI.20588	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	622	208	P	S	Cca/Tca	-4.86	0	0	benign	0.02	neutral	0.83	neutral	4.7	neutral	-2.38	neutral	0.57	neutral_impact	0.3	0.89	neutral	0.95	neutral	0.08	3.42	deleterious	0.54	0.6	0.33	neutral	0.15	neutral	0.18	neutral	0.3	neutral	4	0.13	neutral	0.91	deleterious	-6	neutral	0.11	neutral	0.86	medium_impact	0.61	medium_impact	-0.93	medium_impact	0.29	0.8	26.53	19.06	0.35	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12958	12958	C	G	MI.20589	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	622	208	P	A	Cca/Gca	-4.86	0	0	benign	0.25	neutral	0.99	neutral	4.74	neutral	-1.82	neutral	-0.32	low_impact	1.25	0.85	neutral	0.83	neutral	-0.64	0.10	neutral	0.48	0.55	0.32	neutral	0.1	neutral	0.34	neutral	0.3	neutral	4	0.23	neutral	0.87	deleterious	-6	neutral	0.26	neutral	-0.29	medium_impact	1.33	medium_impact	-0.06	medium_impact	0.80	0.85	26.53	19.06	0.27	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5991	5991	G	C	MI.2059	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	88	30	G	R	Ggc/Cgc	-8.66	0	0	probably_damaging	1	deleterious	0	neutral	2.2	deleterious	-5.45	deleterious	-4.19	high_impact	4.55	0.63	neutral	0.08	damaging	3.69	23.30	deleterious	0.08	0.55	0.89	disease	0.9	disease	0.8	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.72	0.9	2.14	8.62	0.45	N	0.95	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12959	12959	C	G	MI.20590	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	623	208	P	R	cCa/cGa	-1.65	0	0	possibly_damaging	0.57	neutral	0.6	neutral	4.66	deleterious	-3.3	neutral	-0.67	medium_impact	1.99	0.83	neutral	0.49	neutral	1.64	14.06	neutral	0.4	0.5	0.28	neutral	0.4	neutral	0.6	disease	0.46	neutral	1	0.51	neutral	0.52	deleterious	0	NA	0.53	deleterious	-0.86	medium_impact	0.33	medium_impact	0.62	medium_impact	0.70	0.85	26.53	19.06	0.24	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12959	12959	C	A	MI.20591	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	623	208	P	Q	cCa/cAa	-1.65	0	0	possibly_damaging	0.75	neutral	0.59	neutral	4.69	neutral	-2.77	neutral	-0.17	low_impact	1.18	0.85	neutral	0.76	neutral	2.21	17.59	deleterious	0.32	0.5	0.26	neutral	0.26	neutral	0.28	neutral	0.43	neutral	1	0.71	neutral	0.42	neutral	-3	neutral	0.52	deleterious	-1.2	low_impact	0.32	medium_impact	-0.13	medium_impact	0.62	0.8	26.53	19.06	0.29	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12959	12959	C	T	MI.20592	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	623	208	P	L	cCa/cTa	-1.65	0	0	benign	0.02	neutral	0.92	neutral	4.75	neutral	-2.75	neutral	-0.46	neutral_impact	-0.32	0.8	neutral	0.95	neutral	0.49	7.34	deleterious	0.43	0.55	0.39	neutral	0.24	neutral	0.42	neutral	0.43	neutral	1	0.04	neutral	0.95	deleterious	-6	neutral	0.35	neutral	0.86	medium_impact	0.82	medium_impact	-1.5	low_impact	0.74	0.85	26.53	19.06	0.24	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12961	12961	A	C	MI.20593	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	625	209	S	R	Agc/Cgc	-5.78	0	0	benign	0.26	neutral	0.34	neutral	4.62	neutral	-0.44	neutral	-1.88	low_impact	1.36	0.73	neutral	0.45	neutral	2.04	16.46	deleterious	0.39	0.5	0.66	disease	0.69	disease	0.63	disease	0.72	disease	4	0.59	neutral	0.54	deleterious	-6	neutral	0.45	deleterious	-0.32	medium_impact	0.07	medium_impact	0.04	medium_impact	0.75	0.85	21.39	17.32	0.27	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12961	12961	A	G	MI.20594	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	625	209	S	G	Agc/Ggc	-5.78	0	0	benign	0.18	neutral	0.34	neutral	4.58	neutral	-1.72	neutral	-2.09	neutral_impact	0.5	0.78	neutral	0.62	neutral	1.60	13.83	neutral	0.56	0.6	0.74	disease	0.24	neutral	0.44	neutral	0.58	disease	2	0.59	neutral	0.58	deleterious	-6	neutral	0.20	neutral	-0.12	medium_impact	0.07	medium_impact	-0.75	medium_impact	0.62	0.8	21.39	17.32	0.32	N	0.22	polymorphism	1	0.02	rs386829171	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	12961	12961	A	T	MI.20595	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	625	209	S	C	Agc/Tgc	-5.78	0	0	possibly_damaging	0.89	neutral	0.19	neutral	4.59	neutral	-1.4	deleterious	-2.77	low_impact	1.86	0.72	neutral	0.39	neutral	3.30	22.90	deleterious	0.5	0.6	0.9	disease	0.54	disease	0.5	neutral	0.65	disease	3	0.93	neutral	0.15	neutral	-3	neutral	0.69	deleterious	-1.61	low_impact	-0.12	medium_impact	0.5	medium_impact	0.66	0.8	21.39	17.32	0.29	N	0.59	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12962	12962	G	T	MI.20596	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	626	209	S	I	aGc/aTc	-2.57	0	0	possibly_damaging	0.62	neutral	0.43	neutral	4.76	neutral	1.2	neutral	-2.41	neutral_impact	0.7	0.84	neutral	0.73	neutral	3.59	23.20	deleterious	0.58	0.65	0.47	neutral	0.58	disease	0.5	neutral	0.47	neutral	1	0.64	neutral	0.41	neutral	-3	neutral	0.48	deleterious	-0.95	medium_impact	0.17	medium_impact	-0.56	medium_impact	0.73	0.85	21.39	17.32	0.25	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12962	12962	G	A	MI.20597	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	626	209	S	N	aGc/aAc	-2.57	0	0	benign	0.01	neutral	0.37	neutral	4.62	neutral	-0.44	neutral	0.78	neutral_impact	-0.2	0.86	neutral	0.98	neutral	-0.54	0.18	neutral	0.78	0.8	0.57	disease	0.26	neutral	0.25	neutral	0.55	disease	1	0.62	neutral	0.68	deleterious	-6	neutral	0.16	neutral	1.15	medium_impact	0.11	medium_impact	-1.39	low_impact	0.55	0.8	21.39	17.32	0.35	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12962	12962	G	C	MI.20598	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	626	209	S	T	aGc/aCc	-2.57	0	0	benign	0.18	neutral	0.59	neutral	4.64	neutral	-0.04	neutral	-0.19	neutral_impact	-0.16	0.85	neutral	0.98	neutral	0.00	2.63	deleterious	0.48	0.55	0.4	neutral	0.14	neutral	0.22	neutral	0.28	neutral	4	0.3	neutral	0.71	deleterious	-6	neutral	0.23	neutral	-0.12	medium_impact	0.32	medium_impact	-1.35	low_impact	0.75	0.85	21.39	17.32	0.33	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12964	12964	C	A	MI.20599	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	628	210	L	I	Ctc/Atc	-3.49	0	0	benign	0.18	neutral	0.49	neutral	4.51	neutral	-1.62	neutral	0.01	neutral_impact	0.58	0.86	neutral	0.97	neutral	0.89	9.98	deleterious	0.56	0.6	0.5	neutral	0.24	neutral	0.2	neutral	0.31	neutral	4	0.41	neutral	0.66	deleterious	-6	neutral	0.35	neutral	-0.12	medium_impact	0.22	medium_impact	-0.67	medium_impact	0.73	0.85	26.2	20.78	0.44	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8623	8623	A	T	MI.206	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	97	33	T	S	Acc/Tcc	-15.14	0	0	benign	0.07	neutral	1	neutral	4.3	neutral	0.09	neutral	-1.2	neutral_impact	-0.01	0.93	neutral	0.96	neutral	-0.20	1.12	neutral	0.6	0.7	0.28	neutral	0.17	neutral	0.42	neutral	0.26	neutral	5	0.07	neutral	0.97	deleterious	-6	neutral	0.14	neutral	0.31	medium_impact	1.98	high_impact	-1.11	low_impact	0.60	0.9	19.47	19.69	0.35	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5991	5991	G	A	MI.2060	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	88	30	G	S	Ggc/Agc	-8.66	0	0	probably_damaging	1	deleterious	0	neutral	2.27	deleterious	-3.45	deleterious	-3.07	high_impact	4.75	0.58	damaging	0.11	damaging	3.98	23.60	deleterious	0.25	0.55	0.82	disease	0.83	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.71	0.9	2.14	8.62	0.63	P	0.73	disease_causing	0.99	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12964	12964	C	G	MI.20600	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	628	210	L	V	Ctc/Gtc	-3.49	0	0	benign	0.02	neutral	0.54	neutral	4.51	neutral	-1.75	neutral	-0.12	neutral_impact	0.64	0.83	neutral	0.82	neutral	0.51	7.48	deleterious	0.61	0.65	0.45	neutral	0.28	neutral	0.55	disease	0.48	neutral	0	0.44	neutral	0.76	deleterious	-6	neutral	0.39	neutral	0.86	medium_impact	0.27	medium_impact	-0.62	medium_impact	0.55	0.8	26.2	20.78	0.3	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12964	12964	C	T	MI.20601	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	628	210	L	F	Ctc/Ttc	-3.49	0	0	benign	0.02	neutral	0.72	neutral	4.47	neutral	-2.49	neutral	-1.22	low_impact	1.5	0.85	neutral	0.78	neutral	0.65	8.52	deleterious	0.59	0.65	0.64	disease	0.41	neutral	0.29	neutral	0.61	disease	2	0.24	neutral	0.85	deleterious	-6	neutral	0.16	neutral	0.86	medium_impact	0.46	medium_impact	0.17	medium_impact	0.68	0.85	26.2	20.78	0.27	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12965	12965	T	A	MI.20602	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	629	210	L	H	cTc/cAc	-3.03	0	0	probably_damaging	0.93	neutral	0.58	neutral	4.43	deleterious	-5.08	neutral	-1.75	medium_impact	2.58	0.77	neutral	0.56	neutral	2.82	21.50	deleterious	0.41	0.5	0.57	disease	0.66	disease	0.67	disease	0.7	disease	4	0.92	neutral	0.33	neutral	1	deleterious	0.70	deleterious	-1.81	low_impact	0.31	medium_impact	1.15	medium_impact	0.50	0.8	26.2	20.78	0.21	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12965	12965	T	C	MI.20603	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	629	210	L	P	cTc/cCc	-3.03	0	0	benign	0.03	neutral	0.34	neutral	4.47	deleterious	-5.11	neutral	-2.08	medium_impact	2.04	0.82	neutral	0.72	neutral	2.65	20.50	deleterious	0.25	0.45	0.55	disease	0.79	disease	0.64	disease	0.7	disease	4	0.64	neutral	0.66	deleterious	-3	neutral	0.72	deleterious	0.69	medium_impact	0.07	medium_impact	0.66	medium_impact	0.55	0.8	26.2	20.78	0.29	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12965	12965	T	G	MI.20604	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	629	210	L	R	cTc/cGc	-3.03	0	0	possibly_damaging	0.59	neutral	0.37	neutral	4.45	deleterious	-4.13	neutral	-1.62	medium_impact	3.13	0.68	neutral	0.47	neutral	2.82	21.50	deleterious	0.33	0.5	0.6	disease	0.79	disease	0.72	disease	0.76	disease	5	0.66	neutral	0.39	neutral	0	NA	0.70	deleterious	-0.9	medium_impact	0.11	medium_impact	1.66	medium_impact	0.58	0.8	26.2	20.78	0.3	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12967	12967	A	C	MI.20605	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	631	211	T	P	Acc/Ccc	-7.38	0	0	benign	0	neutral	0.26	neutral	4.53	deleterious	-3.02	neutral	-2.05	neutral_impact	-0.11	0.91	neutral	0.71	neutral	2.03	16.42	deleterious	0.31	0.45	0.54	disease	0.81	disease	0.49	neutral	0.66	disease	3	0.74	neutral	0.63	deleterious	-6	neutral	0.61	deleterious	2.1	high_impact	-0.02	medium_impact	-1.3	low_impact	0.41	0.8	13.76	11.27	0.3	N	0.48	polymorphism	1	0.02	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12967	12967	A	G	MI.20606	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	631	211	T	A	Acc/Gcc	-7.38	0	0	benign	0.08	neutral	0.61	neutral	4.62	neutral	-0.36	neutral	-0.36	neutral_impact	0.11	0.86	neutral	0.87	neutral	0.08	3.43	deleterious	0.6	0.65	0.43	neutral	0.34	neutral	0.55	disease	0.49	neutral	0	0.3	neutral	0.77	deleterious	-6	neutral	0.19	neutral	0.26	medium_impact	0.34	medium_impact	-1.1	low_impact	0.30	0.8	13.76	11.27	0.28	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12967	12967	A	T	MI.20607	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	631	211	T	S	Acc/Tcc	-7.38	0	0	benign	0.29	neutral	0.48	neutral	4.56	neutral	-1.46	neutral	-1.05	neutral_impact	0.36	0.77	neutral	0.71	neutral	1.51	13.34	neutral	0.54	0.6	0.45	neutral	0.42	neutral	0.54	disease	0.5	neutral	0	0.43	neutral	0.6	deleterious	-6	neutral	0.37	neutral	-0.38	medium_impact	0.21	medium_impact	-0.87	medium_impact	0.52	0.8	13.76	11.27	0.31	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12968	12968	C	A	MI.20608	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	632	211	T	N	aCc/aAc	-5.55	0	0	possibly_damaging	0.48	neutral	0.35	neutral	4.54	neutral	-2.68	neutral	-1.64	neutral_impact	0.7	0.74	neutral	0.78	neutral	3.23	22.80	deleterious	0.38	0.5	0.69	disease	0.64	disease	0.57	disease	0.67	disease	3	0.62	neutral	0.44	neutral	-3	neutral	0.59	deleterious	-0.71	medium_impact	0.08	medium_impact	-0.56	medium_impact	0.68	0.85	13.76	11.27	0.29	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12968	12968	C	G	MI.20609	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	632	211	T	S	aCc/aGc	-5.55	0	0	benign	0.29	neutral	0.48	neutral	4.56	neutral	-1.46	neutral	-1.05	neutral_impact	0.36	0.77	neutral	0.71	neutral	1.75	14.69	neutral	0.54	0.6	0.45	neutral	0.42	neutral	0.54	disease	0.5	neutral	0	0.43	neutral	0.6	deleterious	-6	neutral	0.37	neutral	-0.38	medium_impact	0.21	medium_impact	-0.87	medium_impact	0.52	0.8	13.76	11.27	0.31	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5991	5991	G	T	MI.2061	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	88	30	G	C	Ggc/Tgc	-8.66	0	0	probably_damaging	1	deleterious	0	neutral	2.18	deleterious	-6.58	deleterious	-4.7	high_impact	5.1	0.6	neutral	0.08	damaging	3.94	23.50	deleterious	0.13	0.55	0.96	disease	0.91	disease	0.7	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.61	high_impact	0.51	0.9	2.14	8.62	0.6	P	0.98	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12968	12968	C	T	MI.20610	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	632	211	T	I	aCc/aTc	-5.55	0	0	benign	0	neutral	0.43	neutral	4.72	neutral	0.71	neutral	2.68	neutral_impact	-1.04	0.84	neutral	0.95	neutral	0.03	2.88	deleterious	0.45	0.55	0.35	neutral	0.36	neutral	0.33	neutral	0.46	neutral	1	0.56	neutral	0.72	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.17	medium_impact	-2.15	low_impact	0.62	0.8	13.76	11.27	0.26	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12970	12970	C	A	MI.20611	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	634	212	P	T	Cca/Aca	-7.38	0	0	probably_damaging	1	neutral	0.44	neutral	4.66	neutral	0.32	deleterious	-7.46	medium_impact	1.94	0.7	neutral	0.14	damaging	3.64	23.20	deleterious	0.48	0.55	0.3	neutral	0.61	disease	0.64	disease	0.46	neutral	1	1	deleterious	0.22	neutral	1	deleterious	0.67	deleterious	-3.6	low_impact	0.18	medium_impact	0.57	medium_impact	0.81	0.85	16.25	17.88	0.23	N	0.68	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12970	12970	C	G	MI.20612	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	634	212	P	A	Cca/Gca	-7.38	0	0	probably_damaging	1	neutral	0.58	neutral	4.73	neutral	1.5	deleterious	-7.54	low_impact	0.84	0.79	neutral	0.59	neutral	1.84	15.24	deleterious	0.41	0.5	0.29	neutral	0.44	neutral	0.59	disease	0.41	neutral	2	1	deleterious	0.29	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.31	medium_impact	-0.44	medium_impact	0.77	0.85	16.25	17.88	0.3	N	0.44	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12970	12970	C	T	MI.20613	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	634	212	P	S	Cca/Tca	-7.38	0	0	probably_damaging	1	neutral	0.47	neutral	4.74	neutral	1.64	deleterious	-7.57	low_impact	1.88	0.73	neutral	0.1	damaging	3.83	23.40	deleterious	0.6	0.65	0.46	neutral	0.69	disease	0.63	disease	0.62	disease	2	1	deleterious	0.24	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.2	medium_impact	0.51	medium_impact	0.43	0.8	16.25	17.88	0.24	N	0.50	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12971	12971	C	G	MI.20614	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	635	212	P	R	cCa/cGa	4.31	0.99	0	probably_damaging	1	neutral	0.38	neutral	4.62	neutral	-0.95	deleterious	-8.54	high_impact	3.59	0.68	neutral	0.11	damaging	3.48	23.10	deleterious	0.28	0.45	0.66	disease	0.84	disease	0.77	disease	0.79	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.12	medium_impact	2.08	high_impact	0.69	0.85	16.25	17.88	0.48	N	0.88	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12971	12971	C	T	MI.20615	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	635	212	P	L	cCa/cTa	4.31	0.99	0	probably_damaging	1	neutral	0.69	neutral	4.87	neutral	2.62	deleterious	-9.24	neutral_impact	-0.04	0.67	neutral	0.26	damaging	4.26	23.90	deleterious	0.5	0.6	0.24	neutral	0.79	disease	0.58	disease	0.53	disease	1	1	deleterious	0.35	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.42	medium_impact	-1.24	low_impact	0.77	0.85	16.25	17.88	0.33	N	0.93	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12971	12971	C	A	MI.20616	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	635	212	P	Q	cCa/cAa	4.31	0.99	0	probably_damaging	1	neutral	0.33	neutral	4.62	neutral	-1.1	deleterious	-7.66	high_impact	3.59	0.73	neutral	0.11	damaging	3.95	23.60	deleterious	0.3	0.45	0.66	disease	0.81	disease	0.68	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.75	deleterious	-3.6	low_impact	0.06	medium_impact	2.08	high_impact	0.65	0.8	16.25	17.88	0.44	N	0.82	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12973	12973	C	A	MI.20617	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	637	213	L	M	Cta/Ata	-5.78	0	0	probably_damaging	1	neutral	0.34	neutral	4.52	neutral	-2.79	neutral	-1.47	low_impact	1.44	0.74	neutral	0.74	neutral	3.61	23.20	deleterious	0.4	0.5	0.7	disease	0.53	disease	0.48	neutral	0.51	disease	0	1	deleterious	0.17	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.07	medium_impact	0.11	medium_impact	0.61	0.8	5.97	7.34	0.32	N	0.89	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12973	12973	C	G	MI.20618	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	637	213	L	V	Cta/Gta	-5.78	0	0	probably_damaging	1	neutral	0.59	neutral	4.59	neutral	-1.38	deleterious	-2.6	low_impact	1.77	0.74	neutral	0.12	damaging	3.34	22.90	deleterious	0.37	0.5	0.47	neutral	0.47	neutral	0.5	neutral	0.45	neutral	1	1	deleterious	0.3	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.32	medium_impact	0.41	medium_impact	0.54	0.8	5.97	7.34	0.19	N	0.81	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12974	12974	T	A	MI.20619	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	638	213	L	Q	cTa/cAa	-0.73	0	0	probably_damaging	1	neutral	0.31	neutral	4.54	deleterious	-5.07	deleterious	-5.28	high_impact	3.86	0.7	neutral	0.09	damaging	4.13	23.80	deleterious	0.17	0.45	0.6	disease	0.82	disease	0.58	disease	0.67	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.04	medium_impact	2.32	high_impact	0.52	0.8	5.97	7.34	0.3	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5992	5992	G	A	MI.2062	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	89	30	G	D	gGc/gAc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.2	deleterious	-5.21	deleterious	-3.68	high_impact	5.1	0.61	neutral	0.08	damaging	3.67	23.30	deleterious	0.09	0.55	0.83	disease	0.91	disease	0.79	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.61	high_impact	0.40	0.9	2.14	8.62	0.74	P	0.97	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12974	12974	T	G	MI.20620	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	638	213	L	R	cTa/cGa	-0.73	0	0	probably_damaging	1	neutral	0.34	neutral	4.51	deleterious	-4.9	deleterious	-5.36	high_impact	3.51	0.6	neutral	0.08	damaging	4.06	23.70	deleterious	0.13	0.4	0.72	disease	0.87	disease	0.7	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.07	medium_impact	2	high_impact	0.57	0.8	5.97	7.34	0.24	N	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12974	12974	T	C	MI.20621	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	638	213	L	P	cTa/cCa	-0.73	0	0	probably_damaging	1	neutral	0.36	neutral	4.5	deleterious	-5.95	deleterious	-6.26	medium_impact	2.96	0.66	neutral	0.26	damaging	3.84	23.40	deleterious	0.1	0.4	0.82	disease	0.82	disease	0.7	disease	0.68	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.1	medium_impact	1.5	medium_impact	0.54	0.8	5.97	7.34	0.23	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12976	12976	C	A	MI.20622	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	640	214	L	M	Cta/Ata	-20	0	0	benign	0.05	neutral	0.26	neutral	4.3	deleterious	-3.48	neutral	-0.59	low_impact	1.92	0.89	neutral	0.98	neutral	1.17	11.61	neutral	0.41	0.5	0.32	neutral	0.24	neutral	0.31	neutral	0.45	neutral	1	0.72	neutral	0.61	deleterious	-6	neutral	0.61	deleterious	0.47	medium_impact	-0.02	medium_impact	0.55	medium_impact	0.68	0.85	5.47	9.57	0.44	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12976	12976	C	G	MI.20623	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	640	214	L	V	Cta/Gta	-20	0	0	benign	0.01	neutral	0.54	neutral	4.39	neutral	-1.84	neutral	-1.73	low_impact	1.9	0.86	neutral	0.77	neutral	0.54	7.73	deleterious	0.32	0.5	0.56	disease	0.46	neutral	0.34	neutral	0.6	disease	2	0.45	neutral	0.77	deleterious	-6	neutral	0.38	neutral	1.15	medium_impact	0.27	medium_impact	0.53	medium_impact	0.57	0.8	5.47	9.57	0.3	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12977	12977	T	A	MI.20624	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	641	214	L	Q	cTa/cAa	-6.47	0	0	possibly_damaging	0.81	neutral	0.33	neutral	4.27	deleterious	-5.86	deleterious	-4.13	high_impact	4.17	0.78	neutral	0.52	neutral	4.21	23.90	deleterious	0.18	0.45	0.51	disease	0.81	disease	0.56	disease	0.67	disease	3	0.84	neutral	0.26	neutral	1	deleterious	0.70	deleterious	-1.34	low_impact	0.06	medium_impact	2.61	high_impact	0.56	0.8	5.47	9.57	0.36	N	0.68	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12977	12977	T	G	MI.20625	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	641	214	L	R	cTa/cGa	-6.47	0	0	possibly_damaging	0.66	neutral	0.36	neutral	4.27	deleterious	-5.79	deleterious	-4.36	high_impact	4.53	0.7	neutral	0.39	neutral	3.97	23.60	deleterious	0.15	0.45	0.51	disease	0.87	disease	0.68	disease	0.73	disease	5	0.71	neutral	0.35	neutral	1	deleterious	0.74	deleterious	-1.02	low_impact	0.1	medium_impact	2.94	high_impact	0.55	0.8	5.47	9.57	0.45	N	0.82	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12977	12977	T	C	MI.20626	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	641	214	L	P	cTa/cCa	-6.47	0	0	possibly_damaging	0.66	neutral	0.27	neutral	4.26	deleterious	-6.01	deleterious	-5.12	high_impact	3.98	0.67	neutral	0.47	neutral	3.72	23.30	deleterious	0.18	0.45	0.55	disease	0.88	disease	0.69	disease	0.74	disease	5	0.77	neutral	0.31	neutral	1	deleterious	0.74	deleterious	-1.02	low_impact	-0.01	medium_impact	2.43	high_impact	0.61	0.8	5.47	9.57	0.37	N	0.90	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12979	12979	G	C	MI.20627	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	643	215	G	R	Ggc/Cgc	-2.11	0	0	probably_damaging	0.98	neutral	0.23	neutral	4.57	deleterious	-5.32	deleterious	-7.42	high_impact	3.87	0.7	neutral	0.22	damaging	3.78	23.40	deleterious	0.1	0.4	0.95	disease	0.87	disease	0.73	disease	0.84	disease	7	0.99	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-2.35	low_impact	-0.06	medium_impact	2.33	high_impact	0.72	0.85	7.63	15.83	0.31	N	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12979	12979	G	T	MI.20628	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	643	215	G	C	Ggc/Tgc	-2.11	0	0	probably_damaging	1	neutral	0.12	neutral	4.59	deleterious	-3.45	deleterious	-8.35	low_impact	1.68	0.73	neutral	0.28	damaging	4.03	23.70	deleterious	0.19	0.45	0.98	disease	0.85	disease	0.59	disease	0.8	disease	6	1	deleterious	0.06	neutral	-2	neutral	0.85	deleterious	-3.6	low_impact	-0.25	medium_impact	0.33	medium_impact	0.58	0.8	7.63	15.83	0.32	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12979	12979	G	A	MI.20629	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	643	215	G	S	Ggc/Agc	-2.11	0	0	benign	0.31	neutral	0.37	neutral	4.63	deleterious	-3.56	deleterious	-5.41	medium_impact	1.97	0.76	neutral	0.55	neutral	4.02	23.60	deleterious	0.28	0.45	0.88	disease	0.76	disease	0.52	disease	0.71	disease	4	0.55	neutral	0.53	deleterious	-3	neutral	0.82	deleterious	-0.42	medium_impact	0.11	medium_impact	0.6	medium_impact	0.62	0.8	7.63	15.83	0.26	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5992	5992	G	C	MI.2063	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	89	30	G	A	gGc/gCc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.36	neutral	-2.5	deleterious	-3.06	medium_impact	3.42	0.79	neutral	0.14	damaging	2.93	22.00	deleterious	0.27	0.55	0.8	disease	0.74	disease	0.59	disease	0.67	disease	3	1	deleterious	0	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.06	high_impact	0.62	0.9	2.14	8.62	0.47	N	0.64	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12980	12980	G	C	MI.20630	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	644	215	G	A	gGc/gCc	5	1	0	possibly_damaging	0.84	neutral	0.48	neutral	4.66	neutral	-0.76	deleterious	-5.51	neutral_impact	0.79	0.7	neutral	0.65	neutral	3.02	22.30	deleterious	0.36	0.5	0.88	disease	0.52	disease	0.38	neutral	0.64	disease	3	0.83	neutral	0.32	neutral	-3	neutral	0.80	deleterious	-1.43	low_impact	0.21	medium_impact	-0.48	medium_impact	0.58	0.8	7.63	15.83	0.4	N	0.79	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12980	12980	G	T	MI.20631	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	644	215	G	V	gGc/gTc	5	1	0	probably_damaging	0.98	neutral	0.57	neutral	4.7	neutral	-2.33	deleterious	-8.38	medium_impact	2.98	0.73	neutral	0.29	neutral	3.67	23.20	deleterious	0.24	0.45	0.96	disease	0.82	disease	0.63	disease	0.83	disease	6	0.98	deleterious	0.3	neutral	1	deleterious	0.84	deleterious	-2.35	low_impact	0.3	medium_impact	1.52	medium_impact	0.46	0.8	7.63	15.83	0.4	N	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12980	12980	G	A	MI.20632	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	644	215	G	D	gGc/gAc	5	1	0	probably_damaging	0.96	neutral	0.13	neutral	4.56	deleterious	-6.23	deleterious	-6.47	high_impact	3.87	0.72	neutral	0.27	damaging	3.82	23.40	deleterious	0.13	0.4	0.84	disease	0.89	disease	0.72	disease	0.8	disease	6	0.98	neutral	0.09	neutral	2	deleterious	0.85	deleterious	-2.06	low_impact	-0.22	medium_impact	2.33	high_impact	0.40	0.8	7.63	15.83	0.5	N	0.95	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12982	12982	C	A	MI.20633	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	646	216	L	I	Ctc/Atc	-20	0	0	benign	0.08	neutral	0.45	neutral	4.43	neutral	-2.22	neutral	-1.87	neutral_impact	0.78	0.81	neutral	0.74	neutral	2.37	18.61	deleterious	0.27	0.45	0.49	neutral	0.44	neutral	0.45	neutral	0.38	neutral	2	0.49	neutral	0.69	deleterious	-6	neutral	0.42	neutral	0.26	medium_impact	0.18	medium_impact	-0.49	medium_impact	0.65	0.8	5.97	7.34	0.34	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12982	12982	C	T	MI.20634	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	646	216	L	F	Ctc/Ttc	-20	0	0	benign	0.11	neutral	0.76	neutral	4.24	neutral	-2.02	deleterious	-3.79	low_impact	1.54	0.75	neutral	0.67	neutral	1.99	16.16	deleterious	0.28	0.45	0.75	disease	0.56	disease	0.38	neutral	0.5	neutral	0	0.13	neutral	0.83	deleterious	-6	neutral	0.23	neutral	0.12	medium_impact	0.51	medium_impact	0.2	medium_impact	0.52	0.8	5.97	7.34	0.26	N	0.18	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12982	12982	C	G	MI.20635	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	646	216	L	V	Ctc/Gtc	-20	0	0	benign	0.39	neutral	0.59	neutral	4.24	neutral	-2.75	deleterious	-2.83	low_impact	1.6	0.76	neutral	0.45	neutral	1.72	14.50	neutral	0.28	0.45	0.71	disease	0.45	neutral	0.48	neutral	0.59	disease	2	0.36	neutral	0.6	deleterious	-6	neutral	0.44	deleterious	-0.56	medium_impact	0.32	medium_impact	0.26	medium_impact	0.64	0.8	5.97	7.34	0.28	N	0.53	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12983	12983	T	G	MI.20636	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	647	216	L	R	cTc/cGc	-0.27	0	0	probably_damaging	0.95	neutral	0.34	neutral	4.1	deleterious	-6.25	deleterious	-5.73	high_impact	4.51	0.62	neutral	0.27	damaging	4.08	23.70	deleterious	0.14	0.4	0.94	disease	0.84	disease	0.68	disease	0.81	disease	6	0.95	neutral	0.2	neutral	2	deleterious	0.84	deleterious	-1.96	low_impact	0.07	medium_impact	2.92	high_impact	0.38	0.8	5.97	7.34	0.39	N	0.95	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12983	12983	T	A	MI.20637	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	647	216	L	H	cTc/cAc	-0.27	0	0	probably_damaging	0.98	neutral	0.59	neutral	4.1	deleterious	-6.87	deleterious	-6.67	high_impact	4.51	0.68	neutral	0.3	neutral	4.02	23.60	deleterious	0.16	0.45	0.96	disease	0.76	disease	0.64	disease	0.8	disease	6	0.97	neutral	0.31	neutral	2	deleterious	0.80	deleterious	-2.35	low_impact	0.32	medium_impact	2.92	high_impact	0.38	0.8	5.97	7.34	0.35	N	0.85	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12983	12983	T	C	MI.20638	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	647	216	L	P	cTc/cCc	-0.27	0	0	probably_damaging	0.98	neutral	0.28	neutral	4.1	deleterious	-6.91	deleterious	-6.68	high_impact	3.96	0.64	neutral	0.29	neutral	3.77	23.40	deleterious	0.22	0.45	0.96	disease	0.81	disease	0.68	disease	0.8	disease	6	0.98	neutral	0.15	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	0.01	medium_impact	2.41	high_impact	0.44	0.8	5.97	7.34	0.32	N	0.90	polymorphism	0.55	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12985	12985	C	T	MI.20639	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	649	217	L	F	Ctc/Ttc	-14.72	0	0	probably_damaging	0.99	neutral	0.62	neutral	4.49	neutral	-1.28	deleterious	-3.55	low_impact	1.47	0.69	neutral	0.71	neutral	3.92	23.50	deleterious	0.25	0.45	0.55	disease	0.4	neutral	0.53	disease	0.63	disease	3	0.99	deleterious	0.32	neutral	-2	neutral	0.69	deleterious	-2.64	low_impact	0.35	medium_impact	0.14	medium_impact	0.40	0.8	15.59	14.84	0.31	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5992	5992	G	T	MI.2064	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	89	30	G	V	gGc/gTc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.22	deleterious	-4.46	deleterious	-4.71	high_impact	5.1	0.61	neutral	0.09	damaging	3.58	23.20	deleterious	0.11	0.55	0.92	disease	0.89	disease	0.69	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.61	high_impact	0.61	0.9	2.14	8.62	0.7	P	0.93	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12985	12985	C	A	MI.20640	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	649	217	L	I	Ctc/Atc	-14.72	0	0	probably_damaging	0.96	neutral	0.45	neutral	4.54	neutral	-2.24	neutral	-1.44	neutral_impact	0.04	0.78	neutral	0.93	neutral	1.32	12.35	neutral	0.26	0.45	0.63	disease	0.03	neutral	0.18	neutral	0.38	neutral	2	0.96	neutral	0.25	neutral	-2	neutral	0.66	deleterious	-2.06	low_impact	0.18	medium_impact	-1.17	low_impact	0.58	0.8	15.59	14.84	0.44	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12985	12985	C	G	MI.20641	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	649	217	L	V	Ctc/Gtc	-14.72	0	0	probably_damaging	0.94	neutral	0.55	neutral	4.52	neutral	-2.08	neutral	-2.3	low_impact	0.93	0.81	neutral	0.98	neutral	1.91	15.66	deleterious	0.26	0.45	0.68	disease	0.25	neutral	0.31	neutral	0.56	disease	1	0.94	neutral	0.31	neutral	-2	neutral	0.70	deleterious	-1.88	low_impact	0.28	medium_impact	-0.35	medium_impact	0.50	0.8	15.59	14.84	0.31	N	0.40	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12986	12986	T	A	MI.20642	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	650	217	L	H	cTc/cAc	-0.27	0	0	probably_damaging	1	neutral	0.4	neutral	4.35	deleterious	-6.45	deleterious	-6.33	high_impact	4.03	0.7	neutral	0.52	neutral	4.07	23.70	deleterious	0.17	0.45	0.95	disease	0.62	disease	0.63	disease	0.82	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.14	medium_impact	2.48	high_impact	0.47	0.8	15.59	14.84	0.35	N	0.85	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12986	12986	T	C	MI.20643	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	650	217	L	P	cTc/cCc	-0.27	0	0	benign	0.38	neutral	0.23	neutral	4.35	deleterious	-5.73	deleterious	-6.28	high_impact	4.03	0.62	neutral	0.39	neutral	3.84	23.40	deleterious	0.19	0.45	0.7	disease	0.84	disease	0.68	disease	0.76	disease	5	0.73	neutral	0.43	neutral	-2	neutral	0.84	deleterious	-0.54	medium_impact	-0.06	medium_impact	2.48	high_impact	0.50	0.8	15.59	14.84	0.35	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12986	12986	T	G	MI.20644	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	650	217	L	R	cTc/cGc	-0.27	0	0	probably_damaging	0.99	neutral	0.24	neutral	4.35	deleterious	-5.93	deleterious	-5.49	high_impact	4.03	0.65	neutral	0.48	neutral	4.12	23.80	deleterious	0.15	0.4	0.94	disease	0.82	disease	0.67	disease	0.79	disease	6	0.99	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-2.64	low_impact	-0.04	medium_impact	2.48	high_impact	0.46	0.8	15.59	14.84	0.35	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12988	12988	C	A	MI.20645	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	652	218	L	M	Cta/Ata	-6.7	0	0	probably_damaging	1	neutral	0.23	neutral	4.47	deleterious	-3.17	neutral	-1.84	medium_impact	2.23	0.72	neutral	0.18	damaging	3.65	23.20	deleterious	0.3	0.45	0.57	disease	0.41	neutral	0.47	neutral	0.58	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.69	deleterious	-3.6	low_impact	-0.06	medium_impact	0.83	medium_impact	0.65	0.8	16.25	15.32	0.33	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12988	12988	C	G	MI.20646	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	652	218	L	V	Cta/Gta	-6.7	0	0	probably_damaging	1	neutral	0.52	neutral	4.66	neutral	-2.34	deleterious	-2.67	low_impact	1.13	0.75	neutral	0.33	neutral	2.24	17.80	deleterious	0.3	0.45	0.54	disease	0.27	neutral	0.36	neutral	0.51	disease	0	1	deleterious	0.26	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.25	medium_impact	-0.17	medium_impact	0.53	0.8	16.25	15.32	0.26	N	0.43	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12989	12989	T	C	MI.20647	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	653	218	L	P	cTa/cCa	-3.03	0	0	probably_damaging	1	neutral	0.24	neutral	4.36	deleterious	-6.65	deleterious	-6.58	high_impact	4.05	0.62	neutral	0.09	damaging	3.83	23.40	deleterious	0.16	0.45	0.94	disease	0.82	disease	0.71	disease	0.79	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.04	medium_impact	2.5	high_impact	0.56	0.8	16.25	15.32	0.29	N	0.91	polymorphism	0.88	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12989	12989	T	A	MI.20648	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	653	218	L	Q	cTa/cAa	-3.03	0	0	probably_damaging	1	neutral	0.3	neutral	4.36	deleterious	-6.27	deleterious	-5.66	high_impact	4.39	0.68	neutral	0.1	damaging	3.99	23.60	deleterious	0.16	0.45	0.92	disease	0.74	disease	0.59	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.03	medium_impact	2.81	high_impact	0.55	0.8	16.25	15.32	0.36	N	0.95	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12989	12989	T	G	MI.20649	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	653	218	L	R	cTa/cGa	-3.03	0	0	probably_damaging	1	neutral	0.35	neutral	4.37	deleterious	-6.04	deleterious	-5.67	high_impact	4.39	0.6	damaging	0.08	damaging	4.09	23.70	deleterious	0.14	0.4	0.91	disease	0.82	disease	0.71	disease	0.79	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.08	medium_impact	2.81	high_impact	0.53	0.8	16.25	15.32	0.35	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5994	5994	A	T	MI.2065	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	91	31	T	S	Aca/Tca	-12.83	0	0	benign	0	neutral	0.14	neutral	2.79	neutral	-2.9	neutral	-1.56	low_impact	1	0.7	neutral	0.61	neutral	0.16	4.30	deleterious	0.42	0.55	0.4	neutral	0.57	disease	0.28	neutral	0.46	neutral	1	0.86	neutral	0.57	deleterious	-6	neutral	0.18	neutral	2.07	high_impact	-0.25	medium_impact	-0.18	medium_impact	0.73	0.9	8.97	51.24	0.48	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12991	12991	G	A	MI.20650	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	655	219	A	T	Gca/Aca	-3.03	0	0	probably_damaging	1	neutral	0.53	neutral	4.24	deleterious	-3.04	deleterious	-3.83	high_impact	3.6	0.52	damaging	0.02	damaging	4.15	23.80	deleterious	0.26	0.45	0.86	disease	0.71	disease	0.62	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.26	medium_impact	2.09	high_impact	0.64	0.8	28.03	7.19	0.23	N	0.94	polymorphism	0.97	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12991	12991	G	C	MI.20651	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	655	219	A	P	Gca/Cca	-3.03	0	0	probably_damaging	1	neutral	0.22	neutral	4.18	deleterious	-5.46	deleterious	-4.79	high_impact	4.69	0.54	damaging	0.02	damaging	3.75	23.30	deleterious	0.16	0.45	0.97	disease	0.87	disease	0.73	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.07	medium_impact	3.08	high_impact	0.42	0.8	28.03	7.19	0.53	N	0.96	polymorphism	0.9	0.24	.	.	.	.	.	.	COSM6716792	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12991	12991	G	T	MI.20652	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	655	219	A	S	Gca/Tca	-3.03	0	0	probably_damaging	1	neutral	0.6	neutral	4.33	neutral	-2.95	deleterious	-2.87	medium_impact	3.06	0.55	damaging	0.04	damaging	3.62	23.20	deleterious	0.3	0.45	0.76	disease	0.76	disease	0.61	disease	0.65	disease	3	1	deleterious	0.3	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.33	medium_impact	1.59	medium_impact	0.43	0.8	28.03	7.19	0.18	N	0.98	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12992	12992	C	T	MI.20653	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	656	219	A	V	gCa/gTa	7.07	1	0	probably_damaging	1	neutral	0.6	neutral	4.21	neutral	-1.48	deleterious	-3.83	high_impact	3.65	0.52	damaging	0.02	damaging	4.35	24.10	deleterious	0.33	0.5	0.83	disease	0.76	disease	0.62	disease	0.68	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.33	medium_impact	2.13	high_impact	0.64	0.8	28.03	7.19	0.51	N	0.76	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12992	12992	C	A	MI.20654	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	656	219	A	E	gCa/gAa	7.07	1	0	probably_damaging	1	neutral	0.33	neutral	4.19	deleterious	-5.42	deleterious	-4.79	high_impact	4.69	0.57	damaging	0.02	damaging	4.43	24.20	deleterious	0.12	0.4	0.97	disease	0.85	disease	0.72	disease	0.79	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.06	medium_impact	3.08	high_impact	0.42	0.8	28.03	7.19	0.64	P	0.99	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12992	12992	C	G	MI.20655	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	656	219	A	G	gCa/gGa	7.07	1	0	probably_damaging	1	neutral	0.44	neutral	4.53	neutral	0.69	deleterious	-3.83	low_impact	1.03	0.54	damaging	0.06	damaging	3.85	23.40	deleterious	0.3	0.45	0.36	neutral	0.45	neutral	0.51	disease	0.42	neutral	2	1	deleterious	0.22	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.18	medium_impact	-0.26	medium_impact	0.49	0.8	28.03	7.19	0.46	N	0.82	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12994	12994	G	A	MI.20656	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	658	220	A	T	Gca/Aca	-6.7	0	0	probably_damaging	1	neutral	0.42	neutral	4.47	deleterious	-3.36	deleterious	-3.69	high_impact	3.73	0.5	damaging	0.09	damaging	4.14	23.80	deleterious	0.34	0.5	0.72	disease	0.73	disease	0.61	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.16	medium_impact	2.2	high_impact	0.55	0.8	7.13	10.05	0.29	N	0.94	polymorphism	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12994	12994	G	T	MI.20657	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	658	220	A	S	Gca/Tca	-6.7	0	0	probably_damaging	1	neutral	0.52	neutral	4.49	deleterious	-3.55	deleterious	-2.66	medium_impact	3.04	0.49	damaging	0.66	neutral	3.61	23.20	deleterious	0.3	0.45	0.81	disease	0.75	disease	0.52	disease	0.61	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.25	medium_impact	1.57	medium_impact	0.42	0.8	7.13	10.05	0.34	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12994	12994	G	C	MI.20658	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	658	220	A	P	Gca/Cca	-6.7	0	0	probably_damaging	1	neutral	0.2	neutral	4.43	deleterious	-4.08	deleterious	-4.68	medium_impact	3.31	0.53	damaging	0.08	damaging	3.81	23.40	deleterious	0.17	0.45	0.55	disease	0.86	disease	0.74	disease	0.72	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	-0.1	medium_impact	1.82	medium_impact	0.51	0.8	7.13	10.05	0.3	N	0.96	polymorphism	0.98	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12995	12995	C	G	MI.20659	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	659	220	A	G	gCa/gGa	5	1	0	probably_damaging	1	neutral	0.42	neutral	4.44	neutral	-1.54	deleterious	-3.72	medium_impact	3.12	0.48	damaging	0.13	damaging	3.84	23.40	deleterious	0.29	0.45	0.83	disease	0.69	disease	0.61	disease	0.68	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.16	medium_impact	1.65	medium_impact	0.59	0.8	7.13	10.05	0.5	N	0.82	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5994	5994	A	G	MI.2066	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	91	31	T	A	Aca/Gca	-12.83	0	0	benign	0.05	neutral	0.08	neutral	2.76	neutral	-2.12	neutral	-1.99	medium_impact	2	0.59	damaging	0.72	neutral	1.31	12.33	neutral	0.52	0.6	0.3	neutral	0.62	disease	0.3	neutral	0.46	neutral	1	0.91	neutral	0.52	deleterious	-3	neutral	0.18	neutral	0.45	medium_impact	-0.4	medium_impact	0.75	medium_impact	0.54	0.9	8.97	51.24	0.52	N	0.69	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12995	12995	C	T	MI.20660	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	659	220	A	V	gCa/gTa	5	1	0	probably_damaging	1	neutral	0.53	neutral	4.55	neutral	-1.89	deleterious	-3.79	medium_impact	2.87	0.45	damaging	0.07	damaging	4.33	24.00	deleterious	0.49	0.55	0.64	disease	0.75	disease	0.61	disease	0.59	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.26	medium_impact	1.42	medium_impact	0.58	0.8	7.13	10.05	0.55	P	0.76	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12995	12995	C	A	MI.20661	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	659	220	A	E	gCa/gAa	5	1	0	probably_damaging	1	neutral	0.28	neutral	4.43	deleterious	-5.74	deleterious	-4.65	high_impact	5	0.56	damaging	0.08	damaging	4.42	24.20	deleterious	0.14	0.4	0.93	disease	0.84	disease	0.72	disease	0.77	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.01	medium_impact	3.36	high_impact	0.42	0.8	7.13	10.05	0.71	P	0.99	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12997	12997	G	A	MI.20662	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	661	221	A	T	Gca/Aca	-3.03	0	0	benign	0.02	neutral	0.45	neutral	4.52	neutral	-2.66	neutral	2.25	neutral_impact	0.14	0.84	neutral	0.95	neutral	1.24	11.94	neutral	0.56	0.6	0.51	disease	0.06	neutral	0.22	neutral	0.22	neutral	6	0.53	neutral	0.72	deleterious	-6	neutral	0.57	deleterious	0.86	medium_impact	0.18	medium_impact	-1.08	low_impact	0.65	0.8	10.78	11.53	0.43	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	12997	12997	G	C	MI.20663	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	661	221	A	P	Gca/Cca	-3.03	0	0	possibly_damaging	0.81	neutral	0.22	neutral	4.47	deleterious	-5.78	neutral	-1.95	medium_impact	3.48	0.63	neutral	0.36	neutral	3.75	23.30	deleterious	0.18	0.45	0.93	disease	0.86	disease	0.7	disease	0.77	disease	5	0.88	neutral	0.21	neutral	0	NA	0.85	deleterious	-1.34	low_impact	-0.07	medium_impact	1.98	medium_impact	0.56	0.8	10.78	11.53	0.32	N	0.74	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12997	12997	G	T	MI.20664	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	661	221	A	S	Gca/Tca	-3.03	0	0	benign	0.36	neutral	0.48	neutral	4.51	deleterious	-3.2	neutral	-0.1	medium_impact	2.59	0.85	neutral	0.69	neutral	3.31	22.90	deleterious	0.46	0.55	0.76	disease	0.48	neutral	0.47	neutral	0.6	disease	2	0.44	neutral	0.56	deleterious	-3	neutral	0.63	deleterious	-0.51	medium_impact	0.21	medium_impact	1.16	medium_impact	0.49	0.8	10.78	11.53	0.35	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12998	12998	C	G	MI.20665	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	662	221	A	G	gCa/gGa	0.41	0	0	possibly_damaging	0.56	neutral	0.41	neutral	4.54	neutral	-2.22	neutral	-2.41	medium_impact	3.48	0.79	neutral	0.58	neutral	3.57	23.20	deleterious	0.33	0.5	0.51	disease	0.51	disease	0.55	disease	0.65	disease	3	0.61	neutral	0.43	neutral	0	NA	0.56	deleterious	-0.85	medium_impact	0.15	medium_impact	1.98	medium_impact	0.45	0.8	10.78	11.53	0.32	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12998	12998	C	A	MI.20666	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	662	221	A	E	gCa/gAa	0.41	0	0	possibly_damaging	0.48	neutral	0.33	neutral	4.47	deleterious	-5.57	neutral	-1.95	medium_impact	3.13	0.74	neutral	0.52	neutral	4.12	23.80	deleterious	0.15	0.4	0.91	disease	0.78	disease	0.69	disease	0.79	disease	6	0.64	neutral	0.43	neutral	0	NA	0.70	deleterious	-0.71	medium_impact	0.06	medium_impact	1.66	medium_impact	0.51	0.8	10.78	11.53	0.34	N	0.74	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	12998	12998	C	T	MI.20667	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	662	221	A	V	gCa/gTa	0.41	0	0	benign	0.03	neutral	0.55	neutral	4.6	neutral	-1.28	neutral	-0.86	neutral_impact	0.3	0.78	neutral	0.78	neutral	4.14	23.80	deleterious	0.51	0.6	0.5	disease	0.49	neutral	0.49	neutral	0.36	neutral	3	0.42	neutral	0.76	deleterious	-6	neutral	0.62	deleterious	0.69	medium_impact	0.28	medium_impact	-0.93	medium_impact	0.64	0.8	10.78	11.53	0.27	N	0.47	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13000	13000	G	A	MI.20668	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	664	222	G	S	Ggc/Agc	-8.3	0	0	probably_damaging	1	neutral	0.61	neutral	4.59	deleterious	-3.64	deleterious	-5.74	low_impact	1.79	0.36	damaging	0.04	damaging	4.11	23.70	deleterious	0.45	0.55	0.78	disease	0.78	disease	0.6	disease	0.53	disease	1	1	deleterious	0.31	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	0.34	medium_impact	0.43	medium_impact	0.75	0.85	24.38	7.11	0.39	N	1.00	polymorphism	0.9	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13000	13000	G	T	MI.20669	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	664	222	G	C	Ggc/Tgc	-8.3	0	0	probably_damaging	1	neutral	0.17	neutral	4.57	deleterious	-6.25	deleterious	-8.62	high_impact	4.33	0.46	damaging	0.01	damaging	4.08	23.70	deleterious	0.13	0.4	0.93	disease	0.88	disease	0.66	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.15	medium_impact	2.75	high_impact	0.68	0.85	24.38	7.11	0.35	N	0.97	polymorphism	0.69	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5994	5994	A	C	MI.2067	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	91	31	T	P	Aca/Cca	-12.83	0	0	possibly_damaging	0.57	deleterious	0	neutral	2.7	deleterious	-4.38	deleterious	-2.74	high_impact	4	0.63	neutral	0.46	neutral	2.93	22.00	deleterious	0.13	0.55	0.68	disease	0.9	disease	0.67	disease	0.76	disease	5	1	deleterious	0.22	neutral	5	deleterious	0.60	deleterious	-0.87	medium_impact	-1.48	low_impact	2.59	high_impact	0.66	0.9	8.97	51.24	0.36	N	0.92	polymorphism	0.95	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13000	13000	G	C	MI.20670	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	664	222	G	R	Ggc/Cgc	-8.3	0	0	probably_damaging	1	neutral	0.38	neutral	4.57	deleterious	-6.06	deleterious	-7.66	high_impact	4.67	0.5	damaging	0.02	damaging	3.89	23.50	deleterious	0.09	0.35	0.91	disease	0.89	disease	0.78	disease	0.76	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.12	medium_impact	3.06	high_impact	0.62	0.8	24.38	7.11	0.49	N	1.00	polymorphism	0.82	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13001	13001	G	T	MI.20671	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	665	222	G	V	gGc/gTc	5.92	1	0	probably_damaging	1	neutral	0.61	neutral	4.82	neutral	-1.91	deleterious	-8.62	high_impact	4.12	0.44	damaging	0.02	damaging	3.70	23.30	deleterious	0.18	0.45	0.47	neutral	0.86	disease	0.68	disease	0.71	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.34	medium_impact	2.56	high_impact	0.63	0.8	24.38	7.11	0.53	N	0.98	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13001	13001	G	A	MI.20672	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	665	222	G	D	gGc/gAc	5.92	1	0	probably_damaging	1	neutral	0.27	neutral	4.56	deleterious	-7.05	deleterious	-6.7	high_impact	4.67	0.46	damaging	0.02	damaging	3.78	23.40	deleterious	0.09	0.4	0.96	disease	0.9	disease	0.77	disease	0.77	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.01	medium_impact	3.06	high_impact	0.49	0.8	24.38	7.11	0.62	P	0.95	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13001	13001	G	C	MI.20673	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	665	222	G	A	gGc/gCc	5.92	1	0	probably_damaging	1	neutral	0.71	neutral	4.66	neutral	-2.48	deleterious	-5.74	low_impact	1.72	0.46	damaging	0.06	damaging	3.04	22.40	deleterious	0.47	0.55	0.6	disease	0.67	disease	0.54	disease	0.53	disease	1	1	deleterious	0.36	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.45	medium_impact	0.37	medium_impact	0.57	0.8	24.38	7.11	0.41	N	0.79	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13003	13003	A	G	MI.20674	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	667	223	K	E	Aaa/Gaa	-5.32	0	0	probably_damaging	1	neutral	0.3	neutral	3.17	deleterious	-5.8	deleterious	-3.83	high_impact	5.24	0.36	damaging	0.37	neutral	3.93	23.50	deleterious	0.23	0.45	0.85	disease	0.77	disease	0.8	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.03	medium_impact	3.58	high_impact	0.51	0.8	27.69	7.26	0.78	P	0.84	polymorphism	0.97	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13003	13003	A	C	MI.20675	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	667	223	K	Q	Aaa/Caa	-5.32	0	0	probably_damaging	1	neutral	0.32	neutral	3.17	deleterious	-5.99	deleterious	-3.83	high_impact	5.24	0.4	damaging	0.41	neutral	3.40	23.00	deleterious	0.25	0.45	0.87	disease	0.76	disease	0.78	disease	0.73	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.05	medium_impact	3.58	high_impact	0.50	0.8	27.69	7.26	0.76	P	0.82	polymorphism	0.98	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13004	13004	A	T	MI.20676	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	668	223	K	M	aAa/aTa	8.44	1	0	probably_damaging	1	neutral	0.23	neutral	3.13	deleterious	-8.44	deleterious	-5.74	high_impact	4.89	0.4	damaging	0.47	neutral	3.89	23.50	deleterious	0.17	0.45	0.93	disease	0.78	disease	0.79	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.06	medium_impact	3.26	high_impact	0.40	0.8	27.69	7.26	0.81	P	0.40	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13004	13004	A	C	MI.20677	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	668	223	K	T	aAa/aCa	8.44	1	0	probably_damaging	1	neutral	0.42	neutral	3.15	deleterious	-6.65	deleterious	-5.74	high_impact	5.24	0.37	damaging	0.35	neutral	3.57	23.10	deleterious	0.17	0.45	0.72	disease	0.72	disease	0.76	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.16	medium_impact	3.58	high_impact	0.36	0.8	27.69	7.26	0.8	P	0.75	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13005	13005	A	C	MI.20678	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	669	223	K	N	aaA/aaC	8.44	1	0	probably_damaging	1	neutral	0.32	neutral	3.18	deleterious	-5.54	deleterious	-4.79	high_impact	4.89	0.29	damaging	0.35	neutral	3.74	23.30	deleterious	0.29	0.45	0.91	disease	0.77	disease	0.78	disease	0.75	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.05	medium_impact	3.26	high_impact	0.38	0.8	27.69	7.26	0.93	P	0.63	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13005	13005	A	T	MI.20679	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	669	223	K	N	aaA/aaT	8.44	1	0	probably_damaging	1	neutral	0.32	neutral	3.18	deleterious	-5.54	deleterious	-4.79	high_impact	4.89	0.29	damaging	0.35	neutral	3.84	23.40	deleterious	0.29	0.45	0.91	disease	0.77	disease	0.78	disease	0.75	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.05	medium_impact	3.26	high_impact	0.38	0.8	27.69	7.26	0.93	P	0.63	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5995	5995	C	A	MI.2068	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	92	31	T	K	aCa/aAa	5.68	1	0	benign	0.2	deleterious	0	neutral	2.71	deleterious	-3.43	deleterious	-2.64	high_impact	4.34	0.67	neutral	0.44	neutral	2.47	19.26	deleterious	0.17	0.55	0.52	disease	0.9	disease	0.59	disease	0.75	disease	5	1	deleterious	0.4	neutral	2	deleterious	0.42	neutral	-0.19	medium_impact	-1.48	low_impact	2.91	high_impact	0.75	0.9	8.97	51.24	0.49	P	0.88	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13006	13006	T	G	MI.20680	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	670	224	S	A	Tca/Gca	2.48	1	0	probably_damaging	1	neutral	0.62	neutral	4.5	neutral	-1.2	deleterious	-2.87	high_impact	4.18	0.38	damaging	0.08	damaging	3.67	23.30	deleterious	0.47	0.55	0.62	disease	0.57	disease	0.66	disease	0.65	disease	3	1	deleterious	0.31	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.35	medium_impact	2.62	high_impact	0.68	0.85	29.19	7.24	0.63	P	0.49	disease_causing	0.95	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13006	13006	T	A	MI.20681	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	670	224	S	T	Tca/Aca	2.48	1	0	probably_damaging	1	neutral	0.48	neutral	4.45	deleterious	-3.18	deleterious	-2.87	high_impact	4.87	0.38	damaging	0.03	damaging	3.87	23.50	deleterious	0.36	0.5	0.79	disease	0.62	disease	0.68	disease	0.68	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.21	medium_impact	3.25	high_impact	0.68	0.85	29.19	7.24	0.7	P	0.71	disease_causing	0.98	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13006	13006	T	C	MI.20682	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	670	224	S	P	Tca/Cca	2.48	1	0	probably_damaging	1	neutral	0.23	neutral	4.4	deleterious	-6.04	deleterious	-4.79	high_impact	5.22	0.35	damaging	0.04	damaging	3.97	23.60	deleterious	0.33	0.5	0.95	disease	0.82	disease	0.7	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.06	medium_impact	3.57	high_impact	0.60	0.8	29.19	7.24	0.66	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13007	13007	C	G	MI.20683	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	671	224	S	W	tCa/tGa	5.69	1	0	probably_damaging	1	neutral	0.2	neutral	4.39	deleterious	-7.04	deleterious	-6.7	high_impact	5.22	0.43	damaging	0.02	damaging	4.27	24.00	deleterious	0.2	0.45	0.97	disease	0.87	disease	0.74	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.1	medium_impact	3.57	high_impact	0.37	0.8	29.19	7.24	0.64	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13007	13007	C	T	MI.20684	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	671	224	S	L	tCa/tTa	5.69	1	0	probably_damaging	1	neutral	0.72	neutral	4.67	neutral	-2.04	deleterious	-5.74	high_impact	5.22	0.37	damaging	0.01	damaging	4.53	24.30	deleterious	0.31	0.45	0.49	neutral	0.84	disease	0.65	disease	0.7	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.46	medium_impact	3.57	high_impact	0.80	0.85	29.19	7.24	0.72	P	0.99	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13009	13009	G	A	MI.20685	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	673	225	A	T	Gcc/Acc	-10.6	0	0	probably_damaging	1	neutral	0.52	neutral	4.35	neutral	-2.02	deleterious	-3.83	high_impact	4.26	0.27	damaging	0.11	damaging	4.17	23.80	deleterious	0.36	0.5	0.83	disease	0.69	disease	0.67	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.25	medium_impact	2.69	high_impact	0.76	0.85	27.03	7.24	0.69	P	0.94	polymorphism	0.97	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13009	13009	G	C	MI.20686	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	673	225	A	P	Gcc/Ccc	-10.6	0	0	probably_damaging	1	neutral	0.2	neutral	4.56	neutral	-0.37	deleterious	-4.79	high_impact	4.81	0.32	damaging	0.1	damaging	3.81	23.40	deleterious	0.26	0.45	0.67	disease	0.8	disease	0.66	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.1	medium_impact	3.19	high_impact	0.82	0.85	27.03	7.24	0.63	P	0.96	polymorphism	0.89	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13009	13009	G	T	MI.20687	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	673	225	A	S	Gcc/Tcc	-10.6	0	0	probably_damaging	1	neutral	0.65	neutral	4.43	neutral	-1.22	deleterious	-2.87	medium_impact	2.88	0.35	damaging	0.11	damaging	3.64	23.20	deleterious	0.32	0.5	0.74	disease	0.68	disease	0.62	disease	0.57	disease	1	1	deleterious	0.33	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.38	medium_impact	1.43	medium_impact	0.75	0.85	27.03	7.24	0.45	N	0.98	polymorphism	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13010	13010	C	T	MI.20688	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	674	225	A	V	gCc/gTc	5.92	1	0	probably_damaging	1	neutral	0.63	neutral	4.26	deleterious	-4.3	deleterious	-3.83	high_impact	4.61	0.2	damaging	0.06	damaging	4.38	24.10	deleterious	0.42	0.55	0.81	disease	0.71	disease	0.66	disease	0.68	disease	4	1	deleterious	0.32	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.36	medium_impact	3.01	high_impact	0.86	0.9	27.03	7.24	0.85	P	0.76	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13010	13010	C	A	MI.20689	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	674	225	A	D	gCc/gAc	5.92	1	0	probably_damaging	1	neutral	0.22	neutral	4.26	deleterious	-4.88	deleterious	-5.74	high_impact	5.16	0.4	damaging	0.1	damaging	4.56	24.40	deleterious	0.19	0.45	0.94	disease	0.86	disease	0.77	disease	0.73	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.07	medium_impact	3.51	high_impact	0.65	0.8	27.03	7.24	0.78	P	0.95	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5995	5995	C	T	MI.2069	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	92	31	T	M	aCa/aTa	5.68	1	0	benign	0.07	deleterious	0.01	neutral	2.76	neutral	-2.53	neutral	-2.4	medium_impact	2.02	0.51	damaging	0.65	neutral	0.84	9.73	deleterious	0.27	0.55	0.24	neutral	0.74	disease	0.32	neutral	0.53	disease	1	0.99	deleterious	0.47	deleterious	1	deleterious	0.18	neutral	0.3	medium_impact	-0.92	medium_impact	0.77	medium_impact	0.79	0.9	8.97	51.24	0.57	P	0.96	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13010	13010	C	G	MI.20690	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	674	225	A	G	gCc/gGc	5.92	1	0	probably_damaging	1	neutral	0.44	neutral	4.59	neutral	-0.25	deleterious	-3.83	high_impact	3.55	0.29	damaging	0.12	damaging	3.91	23.50	deleterious	0.37	0.5	0.63	disease	0.6	disease	0.64	disease	0.65	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.75	deleterious	-3.6	low_impact	0.18	medium_impact	2.04	high_impact	0.81	0.85	27.03	7.24	0.88	P	0.82	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13012	13012	C	A	MI.20691	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	676	226	Q	K	Caa/Aaa	-7.16	0	0	probably_damaging	1	neutral	0.68	neutral	4.43	neutral	-2.19	deleterious	-3.83	high_impact	5.21	0.39	damaging	0.27	damaging	3.92	23.50	deleterious	0.39	0.5	0.9	disease	0.7	disease	0.75	disease	0.75	disease	5	1	deleterious	0.34	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.41	medium_impact	3.56	high_impact	0.57	0.8	27.69	7.2	0.73	P	0.96	disease_causing	0.55	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13012	13012	C	G	MI.20692	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	676	226	Q	E	Caa/Gaa	-7.16	0	0	probably_damaging	1	neutral	0.69	neutral	4.42	deleterious	-4.93	deleterious	-2.87	high_impact	5.21	0.39	damaging	0.33	neutral	3.01	22.30	deleterious	0.38	0.5	0.91	disease	0.54	disease	0.71	disease	0.76	disease	5	1	deleterious	0.35	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.42	medium_impact	3.56	high_impact	0.52	0.8	27.69	7.2	0.69	P	0.92	polymorphism	0.63	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13013	13013	A	T	MI.20693	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	677	226	Q	L	cAa/cTa	7.07	1	0	probably_damaging	1	neutral	0.75	neutral	4.62	neutral	-0.98	deleterious	-6.7	high_impact	3.71	0.32	damaging	0.33	neutral	3.75	23.30	deleterious	0.27	0.45	0.54	disease	0.75	disease	0.66	disease	0.67	disease	3	1	deleterious	0.38	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.5	medium_impact	2.19	high_impact	0.37	0.8	27.69	7.2	0.77	P	0.96	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13013	13013	A	C	MI.20694	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	677	226	Q	P	cAa/cCa	7.07	1	0	probably_damaging	1	neutral	0.34	neutral	4.41	deleterious	-5.6	deleterious	-5.74	high_impact	5.21	0.37	damaging	0.26	damaging	3.24	22.80	deleterious	0.29	0.45	0.94	disease	0.75	disease	0.68	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.07	medium_impact	3.56	high_impact	0.55	0.8	27.69	7.2	0.76	P	0.95	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13013	13013	A	G	MI.20695	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	677	226	Q	R	cAa/cGa	7.07	1	0	probably_damaging	1	neutral	0.51	neutral	4.42	deleterious	-5.17	deleterious	-3.83	high_impact	4.86	0.41	damaging	0.28	damaging	3.38	22.90	deleterious	0.41	0.5	0.92	disease	0.7	disease	0.77	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.24	medium_impact	3.24	high_impact	0.48	0.8	27.69	7.2	0.85	P	0.85	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13014	13014	A	C	MI.20696	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	678	226	Q	H	caA/caC	8.44	1	0	probably_damaging	1	neutral	0.5	neutral	4.41	deleterious	-5.83	deleterious	-4.79	high_impact	4.86	0.37	damaging	0.24	damaging	3.39	23.00	deleterious	0.52	0.6	0.94	disease	0.63	disease	0.77	disease	0.76	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.23	medium_impact	3.24	high_impact	0.72	0.85	27.69	7.2	0.83	P	0.94	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13014	13014	A	T	MI.20697	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	678	226	Q	H	caA/caT	8.44	1	0	probably_damaging	1	neutral	0.5	neutral	4.41	deleterious	-5.83	deleterious	-4.79	high_impact	4.86	0.37	damaging	0.24	damaging	3.69	23.30	deleterious	0.52	0.6	0.94	disease	0.63	disease	0.77	disease	0.76	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.23	medium_impact	3.24	high_impact	0.72	0.85	27.69	7.2	0.85	P	0.94	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13015	13015	T	G	MI.20698	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	679	227	L	V	Tta/Gta	3.85	1	0	possibly_damaging	0.81	neutral	0.51	neutral	4.64	neutral	0.72	neutral	-1	low_impact	0.96	0.57	damaging	0.74	neutral	3.34	22.90	deleterious	0.62	0.65	0.5	neutral	0.43	neutral	0.54	disease	0.42	neutral	2	0.79	neutral	0.35	neutral	-3	neutral	0.72	deleterious	-1.34	low_impact	0.24	medium_impact	-0.33	medium_impact	0.75	0.85	12.27	16.68	0.53	P	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13015	13015	T	A	MI.20699	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	679	227	L	M	Tta/Ata	3.85	1	0	probably_damaging	0.98	neutral	0.22	neutral	4.51	neutral	-1.56	neutral	-0.07	low_impact	1.29	0.61	neutral	0.6	neutral	3.66	23.20	deleterious	0.4	0.5	0.76	disease	0.48	neutral	0.5	neutral	0.59	disease	2	0.98	deleterious	0.12	neutral	-2	neutral	0.78	deleterious	-2.35	low_impact	-0.07	medium_impact	-0.02	medium_impact	0.75	0.85	12.27	16.68	0.55	P	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8623	8623	A	G	MI.207	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	97	33	T	A	Acc/Gcc	-15.14	0	0	benign	0	neutral	0.41	neutral	4.35	neutral	-0.24	neutral	-2.41	low_impact	1.8	0.97	neutral	0.95	neutral	0.69	8.74	deleterious	0.62	0.7	0.41	neutral	0.3	neutral	0.57	disease	0.48	neutral	0	0.59	neutral	0.71	deleterious	-6	neutral	0.15	neutral	2.09	high_impact	0.2	medium_impact	0.45	medium_impact	0.26	0.9	19.47	19.69	0.37	N	0.33	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5997	5997	G	C	MI.2070	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	94	32	A	P	Gct/Cct	-12.13	0	0	probably_damaging	1	deleterious	0.01	neutral	2.72	neutral	-2.82	neutral	-1.77	medium_impact	3.42	0.61	neutral	0.39	neutral	3.67	23.20	deleterious	0.09	0.55	0.69	disease	0.88	disease	0.67	disease	0.79	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.87	deleterious	-3.58	low_impact	-0.92	medium_impact	2.06	high_impact	0.82	0.9	8.38	34.31	0.31	N	0.85	polymorphism	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13016	13016	T	C	MI.20700	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	680	227	L	S	tTa/tCa	3.63	1	0	probably_damaging	0.97	neutral	0.41	neutral	4.53	neutral	-2.8	neutral	-1.99	medium_impact	3.13	0.59	damaging	0.63	neutral	3.76	23.30	deleterious	0.38	0.5	0.86	disease	0.58	disease	0.53	disease	0.61	disease	2	0.97	neutral	0.22	neutral	1	deleterious	0.83	deleterious	-2.18	low_impact	0.15	medium_impact	1.66	medium_impact	0.72	0.85	12.27	16.68	0.47	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13016	13016	T	G	MI.20701	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	680	227	L	W	tTa/tGa	3.63	1	0	probably_damaging	0.99	neutral	0.19	neutral	4.55	neutral	-1.63	neutral	0.7	medium_impact	2.44	0.58	damaging	0.49	neutral	3.75	23.30	deleterious	0.21	0.45	0.75	disease	0.69	disease	0.56	disease	0.69	disease	4	0.99	deleterious	0.1	neutral	1	deleterious	0.81	deleterious	-2.64	low_impact	-0.12	medium_impact	1.03	medium_impact	0.61	0.8	12.27	16.68	0.52	P	0.49	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13017	13017	A	C	MI.20702	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	681	227	L	F	ttA/ttC	7.3	1	0	benign	0.12	neutral	0.72	neutral	4.69	neutral	1.29	neutral	5.25	neutral_impact	-1.62	0.77	neutral	0.92	neutral	0.69	8.74	deleterious	0.47	0.55	0.37	neutral	0.05	neutral	0.15	neutral	0.23	neutral	5	0.17	neutral	0.8	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.46	medium_impact	-2.68	low_impact	0.64	0.8	12.27	16.68	0.56	P	0.02	polymorphism	0.96	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13017	13017	A	T	MI.20703	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	681	227	L	F	ttA/ttT	7.3	1	0	benign	0.12	neutral	0.72	neutral	4.69	neutral	1.29	neutral	5.25	neutral_impact	-1.62	0.77	neutral	0.92	neutral	0.77	9.26	deleterious	0.47	0.55	0.37	neutral	0.05	neutral	0.15	neutral	0.23	neutral	5	0.17	neutral	0.8	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.46	medium_impact	-2.68	low_impact	0.64	0.8	12.27	16.68	0.56	P	0.02	polymorphism	0.96	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13018	13018	G	C	MI.20704	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	682	228	G	R	Ggt/Cgt	-4.4	0	0	probably_damaging	1	neutral	0.35	neutral	4.55	deleterious	-4.63	deleterious	-7.42	high_impact	3.96	0.67	neutral	0.05	damaging	3.89	23.50	deleterious	0.21	0.45	0.86	disease	0.83	disease	0.8	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.08	medium_impact	2.41	high_impact	0.75	0.85	10.78	6.92	0.36	N	1.00	polymorphism	0.8	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13018	13018	G	T	MI.20705	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	682	228	G	C	Ggt/Tgt	-4.4	0	0	probably_damaging	1	neutral	0.18	neutral	4.54	deleterious	-5.32	deleterious	-8.35	high_impact	3.96	0.63	neutral	0.05	damaging	4.13	23.80	deleterious	0.22	0.45	0.91	disease	0.84	disease	0.7	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.13	medium_impact	2.41	high_impact	0.55	0.8	10.78	6.92	0.32	N	0.97	polymorphism	0.67	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13018	13018	G	A	MI.20706	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	682	228	G	S	Ggt/Agt	-4.4	0	0	probably_damaging	1	neutral	0.42	neutral	4.58	neutral	-2.89	deleterious	-5.55	medium_impact	3.27	0.48	damaging	0.4	neutral	4.08	23.70	deleterious	0.27	0.45	0.79	disease	0.71	disease	0.62	disease	0.52	disease	0	1	deleterious	0.21	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.16	medium_impact	1.78	medium_impact	0.66	0.8	10.78	6.92	0.34	N	1.00	polymorphism	0.89	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13019	13019	G	A	MI.20707	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	683	228	G	D	gGt/gAt	2.94	1	0	probably_damaging	1	neutral	0.21	neutral	4.55	deleterious	-5.08	deleterious	-6.49	high_impact	3.96	0.7	neutral	0.06	damaging	3.76	23.30	deleterious	0.21	0.45	0.91	disease	0.86	disease	0.78	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.09	medium_impact	2.41	high_impact	0.43	0.8	10.78	6.92	0.49	P	0.95	polymorphism	0.58	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13019	13019	G	T	MI.20708	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	683	228	G	V	gGt/gTt	2.94	1	0	probably_damaging	1	neutral	0.51	neutral	4.59	deleterious	-3.27	deleterious	-8.35	medium_impact	3.27	0.57	damaging	0.05	damaging	3.68	23.30	deleterious	0.24	0.45	0.67	disease	0.81	disease	0.72	disease	0.69	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.24	medium_impact	1.78	medium_impact	0.54	0.8	10.78	6.92	0.34	N	0.98	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13019	13019	G	C	MI.20709	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	683	228	G	A	gGt/gCt	2.94	1	0	probably_damaging	1	neutral	0.52	neutral	4.62	neutral	-2.41	deleterious	-5.56	high_impact	3.62	0.6	neutral	0.09	damaging	3.05	22.40	deleterious	0.26	0.45	0.51	disease	0.59	disease	0.66	disease	0.65	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.25	medium_impact	2.1	high_impact	0.63	0.8	10.78	6.92	0.36	N	0.79	polymorphism	0.84	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5997	5997	G	A	MI.2071	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	94	32	A	T	Gct/Act	-12.13	0	0	probably_damaging	1	deleterious	0.01	neutral	2.79	neutral	-0.32	neutral	-0.91	medium_impact	2.25	0.63	neutral	0.61	neutral	3.99	23.60	deleterious	0.39	0.55	0.42	neutral	0.45	neutral	0.31	neutral	0.49	neutral	0	1	deleterious	0.01	neutral	5	deleterious	0.71	deleterious	-3.58	low_impact	-0.92	medium_impact	0.98	medium_impact	0.81	0.9	8.38	34.31	0.49	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13021	13021	C	A	MI.20710	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	685	229	L	I	Ctc/Atc	-10.83	0	0	probably_damaging	1	neutral	0.43	neutral	4.19	deleterious	-4.09	neutral	-1.86	high_impact	4.05	0.43	damaging	0.05	damaging	4.03	23.70	deleterious	0.37	0.5	0.65	disease	0.56	disease	0.72	disease	0.68	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.17	medium_impact	2.5	high_impact	0.87	0.9	27.86	7.23	0.42	N	0.85	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13021	13021	C	G	MI.20711	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	685	229	L	V	Ctc/Gtc	-10.83	0	0	probably_damaging	1	neutral	0.53	neutral	4.23	neutral	-2.86	deleterious	-2.79	high_impact	4.59	0.44	damaging	0.04	damaging	3.36	22.90	deleterious	0.48	0.55	0.74	disease	0.48	neutral	0.72	disease	0.64	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.26	medium_impact	2.99	high_impact	0.79	0.85	27.86	7.23	0.45	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13021	13021	C	T	MI.20712	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	685	229	L	F	Ctc/Ttc	-10.83	0	0	probably_damaging	1	neutral	0.72	neutral	4.55	neutral	-0.51	deleterious	-3.72	neutral_impact	0.46	0.44	damaging	0.07	damaging	3.95	23.60	deleterious	0.49	0.55	0.48	neutral	0.5	disease	0.69	disease	0.41	neutral	2	1	deleterious	0.36	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.46	medium_impact	-0.78	medium_impact	0.69	0.85	27.86	7.23	0.29	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13022	13022	T	A	MI.20713	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	686	229	L	H	cTc/cAc	2.25	0.96	0	probably_damaging	1	neutral	0.56	neutral	4.11	deleterious	-6.72	deleterious	-6.51	high_impact	4.59	0.45	damaging	0.03	damaging	4.01	23.60	deleterious	0.18	0.45	0.96	disease	0.69	disease	0.77	disease	0.78	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.29	medium_impact	2.99	high_impact	0.59	0.8	27.86	7.23	0.49	P	0.97	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13022	13022	T	C	MI.20714	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	686	229	L	P	cTc/cCc	2.25	0.96	0	probably_damaging	1	neutral	0.22	neutral	4.11	deleterious	-6.45	deleterious	-6.51	high_impact	4.59	0.43	damaging	0.03	damaging	3.80	23.40	deleterious	0.18	0.45	0.96	disease	0.73	disease	0.7	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.07	medium_impact	2.99	high_impact	0.58	0.8	27.86	7.23	0.5	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13022	13022	T	G	MI.20715	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	686	229	L	R	cTc/cGc	2.25	0.96	0	probably_damaging	1	neutral	0.36	neutral	4.11	deleterious	-6.27	deleterious	-5.58	high_impact	4.59	0.51	damaging	0.03	damaging	4.08	23.70	deleterious	0.18	0.45	0.94	disease	0.79	disease	0.8	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.1	medium_impact	2.99	high_impact	0.62	0.8	27.86	7.23	0.53	P	1.00	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13024	13024	C	G	MI.20716	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	688	230	H	D	Cac/Gac	-12.43	0	0	probably_damaging	1	neutral	0.22	neutral	3.98	deleterious	-5.97	deleterious	-8.37	high_impact	4.93	0.36	damaging	0.02	damaging	3.78	23.40	deleterious	0.33	0.5	0.93	disease	0.76	disease	0.84	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.07	medium_impact	3.3	high_impact	0.42	0.8	28.86	7.27	0.51	P	0.97	polymorphism	0.94	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13024	13024	C	A	MI.20717	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	688	230	H	N	Cac/Aac	-12.43	0	0	probably_damaging	1	neutral	0.32	neutral	4	deleterious	-5.09	deleterious	-6.51	high_impact	3.96	0.37	damaging	0.02	damaging	3.82	23.40	deleterious	0.47	0.55	0.88	disease	0.74	disease	0.78	disease	0.72	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.05	medium_impact	2.41	high_impact	0.48	0.8	28.86	7.27	0.42	N	0.97	polymorphism	0.98	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13024	13024	C	T	MI.20718	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	688	230	H	Y	Cac/Tac	-12.43	0	0	probably_damaging	1	neutral	1	neutral	4.01	deleterious	-4.73	deleterious	-5.58	medium_impact	3.17	0.37	damaging	0.02	damaging	3.63	23.20	deleterious	0.41	0.5	0.66	disease	0.76	disease	0.79	disease	0.72	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.83	deleterious	-3.6	low_impact	1.89	high_impact	1.69	medium_impact	0.48	0.8	28.86	7.27	0.38	N	1.00	polymorphism	0.98	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13025	13025	A	T	MI.20719	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	689	230	H	L	cAc/cTc	4.31	0.99	0	probably_damaging	1	neutral	0.71	neutral	3.97	deleterious	-5.42	deleterious	-10.22	high_impact	4.12	0.38	damaging	0.02	damaging	4.27	23.90	deleterious	0.27	0.45	0.73	disease	0.78	disease	0.78	disease	0.72	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.45	medium_impact	2.56	high_impact	0.37	0.8	28.86	7.27	0.65	P	0.97	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5997	5997	G	T	MI.2072	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	94	32	A	S	Gct/Tct	-12.13	0	0	probably_damaging	1	neutral	0.79	neutral	2.81	neutral	0.03	neutral	0.16	neutral_impact	-0.54	0.65	neutral	0.71	neutral	0.80	9.48	deleterious	0.38	0.55	0.36	neutral	0.1	neutral	0.23	neutral	0.27	neutral	5	1	deleterious	0.4	neutral	-2	neutral	0.68	deleterious	-3.58	low_impact	0.51	medium_impact	-1.6	low_impact	0.86	0.9	8.38	34.31	0.34	N	0.64	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13025	13025	A	C	MI.20720	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	689	230	H	P	cAc/cCc	4.31	0.99	0	probably_damaging	1	neutral	0.23	neutral	3.95	deleterious	-6.44	deleterious	-9.29	high_impact	4.58	0.34	damaging	0.04	damaging	3.63	23.20	deleterious	0.27	0.45	0.96	disease	0.8	disease	0.78	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.06	medium_impact	2.98	high_impact	0.39	0.8	28.86	7.27	0.65	P	0.97	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13025	13025	A	G	MI.20721	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	689	230	H	R	cAc/cGc	4.31	0.99	0	probably_damaging	1	neutral	0.37	neutral	3.99	deleterious	-5.56	deleterious	-7.44	high_impact	4.93	0.42	damaging	0.03	damaging	3.41	23.00	deleterious	0.49	0.55	0.92	disease	0.75	disease	0.81	disease	0.76	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.11	medium_impact	3.3	high_impact	0.52	0.8	28.86	7.27	0.65	P	0.99	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13026	13026	C	G	MI.20722	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	690	230	H	Q	caC/caG	8.44	1	0	probably_damaging	1	neutral	0.31	neutral	4.04	deleterious	-4.12	deleterious	-7.44	medium_impact	3.06	0.42	damaging	0.02	damaging	3.54	23.10	deleterious	0.44	0.55	0.82	disease	0.71	disease	0.79	disease	0.72	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.04	medium_impact	1.59	medium_impact	0.59	0.8	28.86	7.27	0.62	P	0.95	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13026	13026	C	A	MI.20723	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	690	230	H	Q	caC/caA	8.44	1	0	probably_damaging	1	neutral	0.31	neutral	4.04	deleterious	-4.12	deleterious	-7.44	medium_impact	3.06	0.42	damaging	0.02	damaging	3.82	23.40	deleterious	0.44	0.55	0.82	disease	0.71	disease	0.79	disease	0.72	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.04	medium_impact	1.59	medium_impact	0.59	0.8	28.86	7.27	0.62	P	0.95	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13027	13027	C	A	MI.20724	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	691	231	P	T	Ccc/Acc	-0.73	0.04	0	probably_damaging	1	neutral	0.39	neutral	4.78	neutral	2.34	deleterious	-7.43	low_impact	1.78	0.51	damaging	0.05	damaging	3.75	23.30	deleterious	0.6	0.65	0.36	neutral	0.45	neutral	0.69	disease	0.44	neutral	1	1	deleterious	0.2	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.13	medium_impact	0.42	medium_impact	0.80	0.85	29.68	7.2	0.27	N	0.91	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13027	13027	C	T	MI.20725	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	691	231	P	S	Ccc/Tcc	-0.73	0.04	0	probably_damaging	1	neutral	0.41	neutral	4.68	neutral	0.9	deleterious	-7.43	low_impact	1.81	0.5	damaging	0.04	damaging	3.77	23.40	deleterious	0.67	0.7	0.55	disease	0.58	disease	0.62	disease	0.54	disease	1	1	deleterious	0.21	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.15	medium_impact	0.45	medium_impact	0.33	0.8	29.68	7.2	0.24	N	0.78	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13027	13027	C	G	MI.20726	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	691	231	P	A	Ccc/Gcc	-0.73	0.04	0	probably_damaging	1	neutral	0.54	neutral	4.72	neutral	0.57	deleterious	-7.43	low_impact	1.64	0.51	damaging	0.05	damaging	2.99	22.20	deleterious	0.56	0.6	0.37	neutral	0.44	neutral	0.68	disease	0.46	neutral	1	1	deleterious	0.27	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.27	medium_impact	0.3	medium_impact	0.82	0.85	29.68	7.2	0.24	N	0.73	disease_causing	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13028	13028	C	G	MI.20727	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	692	231	P	R	cCc/cGc	7.07	1	0	probably_damaging	1	neutral	0.35	neutral	4.67	neutral	-0.87	deleterious	-8.37	high_impact	4.04	0.55	damaging	0.03	damaging	3.56	23.10	deleterious	0.54	0.6	0.66	disease	0.72	disease	0.79	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.08	medium_impact	2.49	high_impact	0.74	0.85	29.68	7.2	0.57	P	0.64	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13028	13028	C	T	MI.20728	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	692	231	P	L	cCc/cTc	7.07	1	0	probably_damaging	1	neutral	0.7	neutral	4.82	neutral	0.38	deleterious	-9.29	low_impact	1.78	0.52	damaging	0.03	damaging	4.36	24.10	deleterious	0.58	0.65	0.42	neutral	0.65	disease	0.68	disease	0.66	disease	3	1	deleterious	0.35	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.44	medium_impact	0.42	medium_impact	0.82	0.85	29.68	7.2	0.38	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13028	13028	C	A	MI.20729	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	692	231	P	H	cCc/cAc	7.07	1	0	probably_damaging	1	neutral	0.56	neutral	4.63	neutral	-2.33	deleterious	-8.37	high_impact	3.69	0.5	damaging	0.02	damaging	3.99	23.60	deleterious	0.46	0.55	0.88	disease	0.67	disease	0.76	disease	0.72	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.29	medium_impact	2.17	high_impact	0.75	0.85	29.68	7.2	0.52	P	0.72	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5998	5998	C	A	MI.2073	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	95	32	A	D	gCt/gAt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.42	neutral	-1.69	high_impact	3.77	0.64	neutral	0.37	neutral	4.40	24.10	deleterious	0.12	0.55	0.76	disease	0.86	disease	0.66	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.38	high_impact	0.73	0.9	8.38	34.31	0.54	P	0.89	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13030	13030	T	C	MI.20730	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	694	232	W	R	Tga/Cga	-10.6	0	0	probably_damaging	1	neutral	0.37	neutral	0.43	deleterious	-12.85	deleterious	-13.01	high_impact	4.68	0.47	damaging	0.04	damaging	3.47	23.10	deleterious	0.29	0.45	0.99	disease	0.83	disease	0.85	disease	0.73	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.11	medium_impact	3.07	high_impact	0.17	0.8	28.52	7.25	0.41	N	0.97	polymorphism	0.97	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13030	13030	T	G	MI.20731	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	694	232	W	G	Tga/Gga	-10.6	0	0	probably_damaging	1	neutral	0.35	neutral	0.43	deleterious	-11.95	deleterious	-12.08	high_impact	5.23	0.44	damaging	0.05	damaging	3.84	23.40	deleterious	0.24	0.45	0.99	disease	0.71	disease	0.82	disease	0.77	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.08	medium_impact	3.57	high_impact	0.17	0.8	28.52	7.25	0.42	N	0.97	polymorphism	0.92	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13031	13031	G	C	MI.20732	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	695	232	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.43	neutral	0.43	deleterious	-12.98	deleterious	-13.01	high_impact	4.88	0.44	damaging	0.06	damaging	3.95	23.60	deleterious	0.23	0.45	0.98	disease	0.84	disease	0.81	disease	0.72	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.17	medium_impact	3.26	high_impact	0.16	0.8	28.52	7.25	0.52	P	0.95	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13031	13031	G	T	MI.20733	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	695	232	W	L	tGa/tTa	7.3	1	0	probably_damaging	1	neutral	0.71	neutral	0.43	deleterious	-11.93	deleterious	-12.08	high_impact	5.23	0.44	damaging	0.03	damaging	4.17	23.80	deleterious	0.2	0.45	0.68	disease	0.71	disease	0.81	disease	0.69	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.45	medium_impact	3.57	high_impact	0.20	0.8	28.52	7.25	0.55	P	0.97	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13032	13032	A	C	MI.20734	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	696	232	W	C	tgA/tgC	8.9	1	0	probably_damaging	1	neutral	0.17	neutral	0.43	deleterious	-13.81	deleterious	-12.08	high_impact	4.88	0.41	damaging	0.03	damaging	3.92	23.50	deleterious	0.28	0.45	0.99	disease	0.81	disease	0.85	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.15	medium_impact	3.26	high_impact	0.17	0.8	28.52	7.25	0.56	P	0.98	disease_causing	1	0.44	rs386829172	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13032	13032	A	T	MI.20735	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	696	232	W	C	tgA/tgT	8.9	1	0	probably_damaging	1	neutral	0.17	neutral	0.43	deleterious	-13.81	deleterious	-12.08	high_impact	4.88	0.41	damaging	0.03	damaging	4.04	23.70	deleterious	0.28	0.45	0.99	disease	0.81	disease	0.85	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.15	medium_impact	3.26	high_impact	0.17	0.8	28.52	7.25	0.56	P	0.98	disease_causing	1	0.44	rs386829172	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13033	13033	C	G	MI.20736	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	697	233	L	V	Ctc/Gtc	2.02	1	0	probably_damaging	1	neutral	0.52	neutral	4.04	deleterious	-4.37	deleterious	-2.79	high_impact	5.24	0.31	damaging	0.14	damaging	3.35	22.90	deleterious	0.49	0.55	0.79	disease	0.36	neutral	0.6	disease	0.59	disease	2	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.25	medium_impact	3.58	high_impact	0.74	0.85	26.87	7.27	0.72	P	0.81	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13033	13033	C	T	MI.20737	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	697	233	L	F	Ctc/Ttc	2.02	1	0	probably_damaging	1	neutral	0.83	neutral	4	deleterious	-6.51	deleterious	-3.72	high_impact	4.89	0.3	damaging	0.12	damaging	3.94	23.50	deleterious	0.41	0.5	0.93	disease	0.44	neutral	0.62	disease	0.62	disease	2	1	deleterious	0.42	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.61	medium_impact	3.26	high_impact	0.70	0.85	26.87	7.27	0.66	P	0.99	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13033	13033	C	A	MI.20738	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	697	233	L	I	Ctc/Atc	2.02	1	0	probably_damaging	1	neutral	0.47	neutral	4.1	deleterious	-4.96	neutral	-1.86	high_impact	4.89	0.31	damaging	0.15	damaging	4.01	23.60	deleterious	0.38	0.5	0.87	disease	0.39	neutral	0.67	disease	0.62	disease	2	1	deleterious	0.24	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.2	medium_impact	3.26	high_impact	0.77	0.85	26.87	7.27	0.79	P	0.85	disease_causing	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13034	13034	T	A	MI.20739	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	698	233	L	H	cTc/cAc	0.87	1	0	probably_damaging	1	neutral	0.55	neutral	3.93	deleterious	-7.57	deleterious	-6.5	high_impact	5.24	0.33	damaging	0.13	damaging	4.26	23.90	deleterious	0.23	0.45	0.97	disease	0.6	disease	0.76	disease	0.74	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.28	medium_impact	3.58	high_impact	0.62	0.8	26.87	7.27	0.65	P	0.97	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	5998	5998	C	T	MI.2074	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	95	32	A	V	gCt/gTt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.98	neutral	1.5	neutral	-1.8	medium_impact	1.98	0.63	neutral	0.46	neutral	4.21	23.90	deleterious	0.29	0.55	0.2	neutral	0.61	disease	0.31	neutral	0.46	neutral	1	1	deleterious	0	neutral	5	deleterious	0.69	deleterious	-3.58	low_impact	-1.48	low_impact	0.73	medium_impact	0.87	0.9	8.38	34.31	0.58	P	0.75	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13034	13034	T	G	MI.20740	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	698	233	L	R	cTc/cGc	0.87	1	0	probably_damaging	1	neutral	0.36	neutral	3.93	deleterious	-7.08	deleterious	-5.58	high_impact	5.24	0.39	damaging	0.13	damaging	4.15	23.80	deleterious	0.21	0.45	0.96	disease	0.68	disease	0.78	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.1	medium_impact	3.58	high_impact	0.59	0.8	26.87	7.27	0.7	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13034	13034	T	C	MI.20741	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	698	233	L	P	cTc/cCc	0.87	1	0	probably_damaging	1	neutral	0.27	neutral	3.93	deleterious	-8.04	deleterious	-6.5	high_impact	4.69	0.32	damaging	0.13	damaging	3.89	23.50	deleterious	0.21	0.45	0.78	disease	0.57	disease	0.68	disease	0.67	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.01	medium_impact	3.08	high_impact	0.57	0.8	26.87	7.27	0.64	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13036	13036	C	T	MI.20742	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	700	234	P	S	Ccc/Tcc	-20	0	0	probably_damaging	1	neutral	0.42	neutral	4.1	deleterious	-5.74	deleterious	-7.44	high_impact	3.62	0.51	damaging	0.03	damaging	3.85	23.40	deleterious	0.23	0.45	0.89	disease	0.63	disease	0.62	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.16	medium_impact	2.1	high_impact	0.25	0.8	28.03	7.19	0.25	N	0.78	polymorphism	0.97	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13036	13036	C	A	MI.20743	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	700	234	P	T	Ccc/Acc	-20	0	0	probably_damaging	1	neutral	0.39	neutral	4.14	deleterious	-5.7	deleterious	-7.44	medium_impact	3.17	0.51	damaging	0.02	damaging	3.65	23.20	deleterious	0.26	0.45	0.68	disease	0.66	disease	0.64	disease	0.65	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.13	medium_impact	1.69	medium_impact	0.44	0.8	28.03	7.19	0.22	N	0.91	polymorphism	0.98	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13036	13036	C	G	MI.20744	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	700	234	P	A	Ccc/Gcc	-20	0	0	probably_damaging	1	neutral	0.53	neutral	4.16	deleterious	-4.66	deleterious	-7.44	medium_impact	2.91	0.4	damaging	0.19	damaging	3.06	22.40	deleterious	0.2	0.45	0.84	disease	0.44	neutral	0.64	disease	0.6	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.26	medium_impact	1.46	medium_impact	0.54	0.8	28.03	7.19	0.37	N	0.73	polymorphism	0.98	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13037	13037	C	A	MI.20745	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	701	234	P	H	cCc/cAc	5.23	1	0	probably_damaging	1	neutral	0.54	neutral	4.08	deleterious	-7.62	deleterious	-8.37	high_impact	5.07	0.51	damaging	0.02	damaging	4.03	23.60	deleterious	0.2	0.45	0.95	disease	0.71	disease	0.66	disease	0.74	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.27	medium_impact	3.43	high_impact	0.50	0.8	28.03	7.19	0.55	P	0.72	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13037	13037	C	G	MI.20746	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	701	234	P	R	cCc/cGc	5.23	1	0	probably_damaging	1	neutral	0.35	neutral	4.09	deleterious	-6.59	deleterious	-8.37	high_impact	5.07	0.56	damaging	0.03	damaging	3.59	23.20	deleterious	0.18	0.45	0.88	disease	0.74	disease	0.75	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.08	medium_impact	3.43	high_impact	0.47	0.8	28.03	7.19	0.59	P	0.64	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13037	13037	C	T	MI.20747	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	701	234	P	L	cCc/cTc	5.23	1	0	probably_damaging	1	neutral	0.7	neutral	4.22	deleterious	-4.52	deleterious	-9.29	medium_impact	3.31	0.46	damaging	0.02	damaging	4.40	24.10	deleterious	0.26	0.45	0.88	disease	0.67	disease	0.63	disease	0.65	disease	3	1	deleterious	0.35	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.44	medium_impact	1.82	medium_impact	0.71	0.85	28.03	7.19	0.46	N	0.97	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13039	13039	T	C	MI.20748	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	703	235	S	P	Tca/Cca	-6.47	0	0	probably_damaging	1	neutral	0.25	neutral	4.6	neutral	-2.02	deleterious	-4.48	medium_impact	2.38	0.6	neutral	0.11	damaging	3.95	23.60	deleterious	0.41	0.5	0.87	disease	0.71	disease	0.68	disease	0.69	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.03	medium_impact	0.97	medium_impact	0.44	0.8	9.12	7.13	0.22	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13039	13039	T	G	MI.20749	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	703	235	S	A	Tca/Gca	-6.47	0	0	probably_damaging	1	neutral	0.57	neutral	4.66	neutral	0.2	neutral	-2.46	neutral_impact	-1.32	0.76	neutral	0.5	neutral	2.50	19.46	deleterious	0.54	0.6	0.54	disease	0.07	neutral	0.17	neutral	0.29	neutral	4	1	deleterious	0.29	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.3	medium_impact	-2.41	low_impact	0.70	0.85	9.12	7.13	0.31	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	5998	5998	C	G	MI.2075	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	95	32	A	G	gCt/gGt	6.14	1	0	probably_damaging	0.99	neutral	0.35	neutral	2.74	neutral	-1.79	neutral	-0.97	low_impact	1.01	0.7	neutral	0.91	neutral	2.50	19.50	deleterious	0.21	0.55	0.62	disease	0.46	neutral	0.29	neutral	0.61	disease	2	0.99	deleterious	0.18	neutral	-2	neutral	0.74	deleterious	-2.64	low_impact	0.04	medium_impact	-0.17	medium_impact	0.81	0.9	8.38	34.31	0.58	P	0.56	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13039	13039	T	A	MI.20750	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	703	235	S	T	Tca/Aca	-6.47	0	0	probably_damaging	1	neutral	0.42	neutral	4.66	neutral	0.07	deleterious	-2.68	medium_impact	1.97	0.71	neutral	0.11	damaging	3.75	23.30	deleterious	0.47	0.55	0.48	neutral	0.39	neutral	0.41	neutral	0.43	neutral	1	1	deleterious	0.21	neutral	1	deleterious	0.70	deleterious	-3.6	low_impact	0.16	medium_impact	0.6	medium_impact	0.63	0.8	9.12	7.13	0.26	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13040	13040	C	G	MI.20751	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	704	235	S	W	tCa/tGa	2.48	0.98	0	probably_damaging	1	neutral	0.19	neutral	4.56	deleterious	-4.05	deleterious	-6.34	medium_impact	2.52	0.72	neutral	0.1	damaging	4.32	24.00	deleterious	0.28	0.45	0.97	disease	0.68	disease	0.64	disease	0.76	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	-0.12	medium_impact	1.1	medium_impact	0.57	0.8	9.12	7.13	0.36	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13040	13040	C	T	MI.20752	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	704	235	S	L	tCa/tTa	2.48	0.98	0	probably_damaging	1	neutral	0.73	neutral	4.59	neutral	-1.18	deleterious	-5.36	low_impact	1.68	0.71	neutral	0.07	damaging	4.62	24.50	deleterious	0.42	0.55	0.67	disease	0.56	disease	0.55	disease	0.62	disease	2	1	deleterious	0.37	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.47	medium_impact	0.33	medium_impact	0.81	0.85	9.12	7.13	0.32	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13042	13042	G	A	MI.20753	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	706	236	A	T	Gcc/Acc	-8.99	0	0	probably_damaging	1	neutral	0.42	neutral	4.12	deleterious	-4.58	deleterious	-3.72	high_impact	4.87	0.25	damaging	0.19	damaging	4.20	23.90	deleterious	0.33	0.5	0.61	disease	0.56	disease	0.75	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.16	medium_impact	3.25	high_impact	0.72	0.85	28.69	7.16	0.85	P	0.94	disease_causing_automatic	0.03	0.22	rs267606898	Pathogenic	Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke|Myoclonus_with_epilepsy_with_ragged_red_fibers|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency	24742	MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003|MedGen:C0162672,OMIM:545000,Orphanet:ORPHA551|MedGen:C1838951	.	COSM5652748	.	.	G13042A	Optic neuropathy/ retinopathy/ LD	-	+	Cfrm	6	P	P	P	damaging
chrM	13042	13042	G	C	MI.20754	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	706	236	A	P	Gcc/Ccc	-8.99	0	0	probably_damaging	1	neutral	0.24	neutral	4.02	deleterious	-6.89	deleterious	-4.65	high_impact	4.41	0.27	damaging	0.27	damaging	3.84	23.40	deleterious	0.24	0.45	0.86	disease	0.59	disease	0.83	disease	0.73	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.04	medium_impact	2.83	high_impact	0.60	0.8	28.69	7.16	0.83	P	0.96	polymorphism	0.9	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13042	13042	G	T	MI.20755	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	706	236	A	S	Gcc/Tcc	-8.99	0	0	probably_damaging	1	neutral	0.45	neutral	4.23	deleterious	-4.3	deleterious	-2.79	high_impact	3.64	0.32	damaging	0.39	neutral	3.68	23.30	deleterious	0.22	0.45	0.76	disease	0.51	disease	0.71	disease	0.64	disease	3	1	deleterious	0.23	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.18	medium_impact	2.12	high_impact	0.69	0.85	28.69	7.16	0.62	P	0.98	polymorphism	0.99	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13043	13043	C	T	MI.20756	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	707	236	A	V	gCc/gTc	8.9	1	0	probably_damaging	1	neutral	0.52	neutral	4.37	neutral	-2.93	deleterious	-3.72	high_impact	4.32	0.15	damaging	0.24	damaging	4.40	24.10	deleterious	0.42	0.55	0.67	disease	0.56	disease	0.74	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.25	medium_impact	2.74	high_impact	0.76	0.85	28.69	7.16	0.96	P	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13043	13043	C	A	MI.20757	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	707	236	A	D	gCc/gAc	8.9	1	0	probably_damaging	1	neutral	0.23	neutral	4.01	deleterious	-7.24	deleterious	-5.58	high_impact	5.21	0.35	damaging	0.32	neutral	4.59	24.40	deleterious	0.2	0.45	0.97	disease	0.7	disease	0.82	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.06	medium_impact	3.56	high_impact	0.61	0.8	28.69	7.16	0.8	P	0.95	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13043	13043	C	G	MI.20758	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	707	236	A	G	gCc/gGc	8.9	1	0	probably_damaging	1	neutral	0.36	neutral	4.03	deleterious	-6.06	deleterious	-3.72	high_impact	5.21	0.28	damaging	0.38	neutral	3.93	23.50	deleterious	0.27	0.45	0.93	disease	0.37	neutral	0.74	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.1	medium_impact	3.56	high_impact	0.72	0.85	28.69	7.16	0.93	P	0.82	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13045	13045	A	T	MI.20759	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	709	237	M	L	Ata/Tta	-8.99	0	0	probably_damaging	0.98	neutral	0.75	neutral	4.53	deleterious	-3.43	deleterious	-2.79	high_impact	5.22	0.44	damaging	0.06	damaging	3.46	23.00	deleterious	0.29	0.45	0.76	disease	0.53	disease	0.77	disease	0.72	disease	4	0.98	deleterious	0.39	neutral	2	deleterious	0.69	deleterious	-2.35	low_impact	0.5	medium_impact	3.57	high_impact	0.35	0.8	27.86	7.11	0.7	P	0.98	disease_causing_automatic	0	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6000	6000	C	G	MI.2076	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	97	33	L	V	Cta/Gta	-10.05	0	0	benign	0.19	deleterious	0.01	neutral	2.62	neutral	-1.59	neutral	-1.3	high_impact	3.81	0.55	damaging	0.42	neutral	1.57	13.67	neutral	0.42	0.55	0.41	neutral	0.52	disease	0.56	disease	0.58	disease	2	0.99	deleterious	0.41	neutral	2	deleterious	0.24	neutral	-0.16	medium_impact	-0.92	medium_impact	2.42	high_impact	0.75	0.9	10.14	39.34	0.44	N	0.66	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13045	13045	A	C	MI.20760	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	709	237	M	L	Ata/Cta	-8.99	0	0	probably_damaging	0.98	neutral	0.75	neutral	4.53	deleterious	-3.43	deleterious	-2.79	high_impact	5.22	0.44	damaging	0.06	damaging	3.31	22.90	deleterious	0.29	0.45	0.76	disease	0.53	disease	0.77	disease	0.72	disease	4	0.98	deleterious	0.39	neutral	2	deleterious	0.69	deleterious	-2.35	low_impact	0.5	medium_impact	3.57	high_impact	0.35	0.8	27.86	7.11	0.73	P	0.98	disease_causing_automatic	0	0.27	rs267606895	Pathogenic	Leber's_optic_atrophy|Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency	24739	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003|MedGen:C1838951	.	.	.	.	A13045C	MELAS / LHON / Leigh overlap syndrome	-	+	Reported	4	P	P	P	damaging
chrM	13045	13045	A	G	MI.20761	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	709	237	M	V	Ata/Gta	-8.99	0	0	probably_damaging	0.99	neutral	0.57	neutral	4.48	neutral	-2.15	deleterious	-3.72	high_impact	5.22	0.42	damaging	0.09	damaging	2.77	21.20	deleterious	0.36	0.5	0.77	disease	0.6	disease	0.8	disease	0.7	disease	4	0.99	deleterious	0.29	neutral	2	deleterious	0.72	deleterious	-2.64	low_impact	0.3	medium_impact	3.57	high_impact	0.35	0.8	27.86	7.11	0.68	P	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13046	13046	T	A	MI.20762	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	710	237	M	K	aTa/aAa	6.61	1	0	probably_damaging	1	neutral	0.55	neutral	4.41	deleterious	-5.47	deleterious	-5.58	high_impact	4.88	0.48	damaging	0.09	damaging	3.93	23.50	deleterious	0.28	0.45	0.93	disease	0.69	disease	0.84	disease	0.77	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.28	medium_impact	3.26	high_impact	0.28	0.8	27.86	7.11	0.75	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13046	13046	T	C	MI.20763	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	710	237	M	T	aTa/aCa	6.61	1	0	probably_damaging	1	neutral	0.58	neutral	4.46	deleterious	-3.88	deleterious	-5.58	high_impact	4.88	0.49	damaging	0.09	damaging	2.94	22.00	deleterious	0.37	0.5	0.83	disease	0.69	disease	0.79	disease	0.72	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.31	medium_impact	3.26	high_impact	0.26	0.8	27.86	7.11	0.72	P	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	T13046C	LHON/MELAS overlap syndrome	-	+	Reported	1	.	.	.	damaging
chrM	13047	13047	A	C	MI.20764	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	711	237	M	I	atA/atC	5.69	1	0	probably_damaging	0.99	neutral	0.45	neutral	4.49	deleterious	-3.84	deleterious	-3.72	high_impact	4.08	0.46	damaging	0.11	damaging	3.37	22.90	deleterious	0.44	0.55	0.8	disease	0.61	disease	0.8	disease	0.71	disease	4	0.99	deleterious	0.23	neutral	2	deleterious	0.78	deleterious	-2.64	low_impact	0.18	medium_impact	2.52	high_impact	0.40	0.8	27.86	7.11	0.7	P	0.94	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13047	13047	A	T	MI.20765	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	711	237	M	I	atA/atT	5.69	1	0	probably_damaging	0.99	neutral	0.45	neutral	4.49	deleterious	-3.84	deleterious	-3.72	high_impact	4.08	0.46	damaging	0.11	damaging	3.45	23.00	deleterious	0.44	0.55	0.8	disease	0.61	disease	0.8	disease	0.71	disease	4	0.99	deleterious	0.23	neutral	2	deleterious	0.78	deleterious	-2.64	low_impact	0.18	medium_impact	2.52	high_impact	0.40	0.8	27.86	7.11	0.71	P	0.94	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13048	13048	G	C	MI.20766	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	712	238	E	Q	Gaa/Caa	3.85	1	0	probably_damaging	1	neutral	0.39	neutral	4.45	neutral	-2.15	deleterious	-2.79	high_impact	4	0.32	damaging	0.06	damaging	3.29	22.80	deleterious	0.56	0.6	0.81	disease	0.57	disease	0.57	disease	0.64	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.13	medium_impact	2.45	high_impact	0.68	0.85	29.19	7.13	0.65	P	0.89	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13048	13048	G	A	MI.20767	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	712	238	E	K	Gaa/Aaa	3.85	1	0	probably_damaging	1	neutral	0.45	neutral	4.41	deleterious	-3.28	deleterious	-3.72	high_impact	3.92	0.3	damaging	0.03	damaging	4.47	24.20	deleterious	0.49	0.55	0.79	disease	0.68	disease	0.65	disease	0.66	disease	3	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.18	medium_impact	2.38	high_impact	0.64	0.8	29.19	7.13	0.73	P	0.99	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13049	13049	A	G	MI.20768	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	713	238	E	G	gAa/gGa	8.9	1	0	probably_damaging	1	neutral	0.41	neutral	4.37	deleterious	-4.32	deleterious	-6.51	high_impact	4.81	0.32	damaging	0.11	damaging	4.16	23.80	deleterious	0.57	0.65	0.87	disease	0.5	neutral	0.56	disease	0.63	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.15	medium_impact	3.19	high_impact	0.52	0.8	29.19	7.13	0.74	P	0.51	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13049	13049	A	C	MI.20769	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	713	238	E	A	gAa/gCa	8.9	1	0	probably_damaging	1	neutral	0.65	neutral	4.44	neutral	-1.68	deleterious	-5.58	low_impact	1.92	0.32	damaging	0.09	damaging	3.56	23.10	deleterious	0.54	0.6	0.68	disease	0.5	disease	0.58	disease	0.57	disease	1	1	deleterious	0.33	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.38	medium_impact	0.55	medium_impact	0.72	0.85	29.19	7.13	0.67	P	0.75	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6000	6000	C	A	MI.2077	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	97	33	L	M	Cta/Ata	-10.05	0	0	benign	0.11	neutral	0.15	neutral	2.63	neutral	-1.41	neutral	-0.38	low_impact	0.85	0.57	damaging	0.68	neutral	0.43	6.91	deleterious	0.34	0.55	0.42	neutral	0.14	neutral	0.27	neutral	0.28	neutral	4	0.83	neutral	0.52	deleterious	-6	neutral	0.17	neutral	0.1	medium_impact	-0.23	medium_impact	-0.31	medium_impact	0.64	0.9	10.14	39.34	0.54	P	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13049	13049	A	T	MI.20770	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	713	238	E	V	gAa/gTa	8.9	1	0	probably_damaging	1	neutral	0.56	neutral	4.54	deleterious	-3.29	deleterious	-6.51	medium_impact	3.16	0.28	damaging	0.06	damaging	4.04	23.70	deleterious	0.45	0.55	0.86	disease	0.72	disease	0.6	disease	0.65	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.29	medium_impact	1.68	medium_impact	0.75	0.85	29.19	7.13	0.79	P	0.81	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13050	13050	A	C	MI.20771	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	714	238	E	D	gaA/gaC	8.44	1	0.01	probably_damaging	1	neutral	0.31	neutral	4.37	deleterious	-3.88	deleterious	-2.79	high_impact	4.46	0.3	damaging	0.05	damaging	3.68	23.30	deleterious	0.52	0.6	0.87	disease	0.53	disease	0.54	disease	0.6	disease	2	1	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.04	medium_impact	2.87	high_impact	0.69	0.85	29.19	7.13	0.7	P	0.86	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13050	13050	A	T	MI.20772	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	714	238	E	D	gaA/gaT	8.44	1	0.01	probably_damaging	1	neutral	0.31	neutral	4.37	deleterious	-3.88	deleterious	-2.79	high_impact	4.46	0.3	damaging	0.05	damaging	3.81	23.40	deleterious	0.52	0.6	0.87	disease	0.53	disease	0.54	disease	0.6	disease	2	1	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.04	medium_impact	2.87	high_impact	0.69	0.85	29.19	7.13	0.7	P	0.86	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13051	13051	G	A	MI.20773	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	715	239	G	S	Ggc/Agc	1.33	1	0	probably_damaging	1	neutral	0.42	neutral	4.44	deleterious	-3.07	deleterious	-5.35	high_impact	4.2	0.38	damaging	0.03	damaging	4.23	23.90	deleterious	0.47	0.55	0.78	disease	0.66	disease	0.68	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.16	medium_impact	2.63	high_impact	0.73	0.85	29.02	7.26	0.71	P	1.00	disease_causing	1	0.18	rs1131692063	Pathogenic	Mitochondrial_diseases	424207	MedGen:C0751651,Orphanet:ORPHA68380	.	.	.	.	G13051A	LHON	+	-	Cfrm	2	.	P	P	damaging
chrM	13051	13051	G	T	MI.20774	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	715	239	G	C	Ggc/Tgc	1.33	1	0	probably_damaging	1	neutral	0.18	neutral	4.32	deleterious	-6.79	deleterious	-8.03	high_impact	4.89	0.29	damaging	0.02	damaging	4.10	23.70	deleterious	0.37	0.5	0.96	disease	0.74	disease	0.71	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.13	medium_impact	3.26	high_impact	0.46	0.8	29.02	7.26	0.7	P	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13051	13051	G	C	MI.20775	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	715	239	G	R	Ggc/Cgc	1.33	1	0	probably_damaging	1	neutral	0.35	neutral	4.38	deleterious	-4.05	deleterious	-7.13	high_impact	4.89	0.35	damaging	0.02	damaging	3.95	23.60	deleterious	0.5	0.6	0.87	disease	0.73	disease	0.79	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.08	medium_impact	3.26	high_impact	0.80	0.85	29.02	7.26	0.7	P	1.00	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13052	13052	G	T	MI.20776	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	716	239	G	V	gGc/gTc	8.9	1	0	probably_damaging	1	neutral	0.52	neutral	4.35	deleterious	-4.89	deleterious	-8.03	high_impact	4.89	0.31	damaging	0.02	damaging	3.74	23.30	deleterious	0.45	0.55	0.81	disease	0.74	disease	0.71	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.25	medium_impact	3.26	high_impact	0.55	0.8	29.02	7.26	0.66	P	0.98	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13052	13052	G	A	MI.20777	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	716	239	G	D	gGc/gAc	8.9	1	0	probably_damaging	1	neutral	0.21	neutral	4.38	deleterious	-4.2	deleterious	-6.24	high_impact	4.89	0.27	damaging	0.02	damaging	3.89	23.50	deleterious	0.47	0.55	0.92	disease	0.76	disease	0.79	disease	0.79	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.09	medium_impact	3.26	high_impact	0.39	0.8	29.02	7.26	0.83	P	0.95	disease_causing	1	0.41	.	.	.	.	.	.	COSM6188323	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13052	13052	G	C	MI.20778	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	716	239	G	A	gGc/gCc	8.9	1	0	probably_damaging	1	neutral	0.51	neutral	4.46	neutral	0.08	deleterious	-5.35	medium_impact	1.98	0.38	damaging	0.03	damaging	3.07	22.40	deleterious	0.61	0.65	0.4	neutral	0.5	neutral	0.64	disease	0.55	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.24	medium_impact	0.61	medium_impact	0.62	0.8	29.02	7.26	0.6	P	0.79	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13054	13054	C	A	MI.20779	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	718	240	P	T	Ccc/Acc	-3.49	0	0	probably_damaging	1	neutral	0.42	neutral	4.46	deleterious	-5.6	deleterious	-7.13	high_impact	4.88	0.32	damaging	0.3	neutral	3.63	23.20	deleterious	0.31	0.5	0.8	disease	0.59	disease	0.67	disease	0.69	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.16	medium_impact	3.26	high_impact	0.50	0.8	26.87	7.18	0.65	P	0.91	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6001	6001	T	C	MI.2078	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	98	33	L	P	cTa/cCa	-1.26	0	0	probably_damaging	0.97	deleterious	0	neutral	2.53	deleterious	-4.36	deleterious	-3.34	high_impact	4.62	0.5	damaging	0.36	neutral	3.68	23.30	deleterious	0.15	0.55	0.72	disease	0.87	disease	0.69	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.18	low_impact	-1.48	low_impact	3.17	high_impact	0.56	0.9	10.14	39.34	0.5	N	0.83	disease_causing	0.87	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13054	13054	C	G	MI.20780	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	718	240	P	A	Ccc/Gcc	-3.49	0	0	probably_damaging	1	neutral	0.54	neutral	4.68	deleterious	-4.4	deleterious	-7.13	high_impact	4.34	0.32	damaging	0.43	neutral	3.00	22.20	deleterious	0.29	0.45	0.82	disease	0.41	neutral	0.67	disease	0.61	disease	2	1	deleterious	0.27	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.27	medium_impact	2.76	high_impact	0.73	0.85	26.87	7.18	0.64	P	0.73	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13054	13054	C	T	MI.20781	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	718	240	P	S	Ccc/Tcc	-3.49	0	0	probably_damaging	1	neutral	0.46	neutral	4.55	deleterious	-5.08	deleterious	-7.13	high_impact	4.68	0.35	damaging	0.4	neutral	3.89	23.50	deleterious	0.36	0.5	0.69	disease	0.6	disease	0.67	disease	0.65	disease	3	1	deleterious	0.23	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.19	medium_impact	3.07	high_impact	0.22	0.8	26.87	7.18	0.61	P	0.78	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13055	13055	C	A	MI.20782	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	719	240	P	H	cCc/cAc	7.07	1	0	probably_damaging	1	neutral	0.55	neutral	4.43	deleterious	-7.25	deleterious	-8.03	high_impact	4.88	0.33	damaging	0.27	damaging	4.01	23.60	deleterious	0.26	0.45	0.87	disease	0.66	disease	0.78	disease	0.71	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.28	medium_impact	3.26	high_impact	0.49	0.8	26.87	7.18	0.75	P	0.72	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13055	13055	C	G	MI.20783	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	719	240	P	R	cCc/cGc	7.07	1	0	probably_damaging	1	neutral	0.34	neutral	4.44	deleterious	-6.26	deleterious	-8.03	high_impact	5.23	0.36	damaging	0.31	neutral	3.57	23.20	deleterious	0.22	0.45	0.89	disease	0.67	disease	0.77	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.07	medium_impact	3.57	high_impact	0.44	0.8	26.87	7.18	0.77	P	0.64	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13055	13055	C	T	MI.20784	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	719	240	P	L	cCc/cTc	7.07	1	0	probably_damaging	1	neutral	0.69	neutral	4.65	deleterious	-6.03	deleterious	-8.92	high_impact	4.88	0.25	damaging	0.34	neutral	4.39	24.10	deleterious	0.27	0.45	0.88	disease	0.62	disease	0.66	disease	0.7	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.42	medium_impact	3.26	high_impact	0.57	0.8	26.87	7.18	0.85	P	0.97	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13057	13057	A	C	MI.20785	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	721	241	T	P	Acc/Ccc	-20	0	0	probably_damaging	1	neutral	0.24	neutral	4.69	deleterious	-4.5	deleterious	-5.35	high_impact	5.21	0.35	damaging	0.33	neutral	4.00	23.60	deleterious	0.32	0.5	0.9	disease	0.47	neutral	0.69	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	-0.04	medium_impact	3.56	high_impact	0.31	0.8	28.86	7.2	0.61	P	0.97	disease_causing	0.51	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13057	13057	A	G	MI.20786	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	721	241	T	A	Acc/Gcc	-20	0	0	probably_damaging	1	neutral	0.54	neutral	4.47	deleterious	-3.26	deleterious	-4.46	high_impact	4.11	0.36	damaging	0.48	neutral	4.01	23.60	deleterious	0.46	0.55	0.79	disease	0.29	neutral	0.69	disease	0.55	disease	1	1	deleterious	0.27	neutral	2	deleterious	0.73	deleterious	-3.6	low_impact	0.27	medium_impact	2.55	high_impact	0.28	0.8	28.86	7.2	0.57	P	0.69	polymorphism	0.83	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13057	13057	A	T	MI.20787	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	721	241	T	S	Acc/Tcc	-20	0	0	probably_damaging	1	neutral	0.48	neutral	4.55	neutral	-2.83	deleterious	-3.57	high_impact	3.89	0.4	damaging	0.48	neutral	3.86	23.50	deleterious	0.46	0.55	0.59	disease	0.37	neutral	0.62	disease	0.56	disease	1	1	deleterious	0.24	neutral	2	deleterious	0.72	deleterious	-3.6	low_impact	0.21	medium_impact	2.35	high_impact	0.33	0.8	28.86	7.2	0.55	P	0.89	polymorphism	0.94	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13058	13058	C	G	MI.20788	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	722	241	T	S	aCc/aGc	8.44	1	0	probably_damaging	1	neutral	0.48	neutral	4.55	neutral	-2.83	deleterious	-3.57	high_impact	3.89	0.4	damaging	0.48	neutral	3.52	23.10	deleterious	0.46	0.55	0.59	disease	0.37	neutral	0.62	disease	0.56	disease	1	1	deleterious	0.24	neutral	2	deleterious	0.72	deleterious	-3.6	low_impact	0.21	medium_impact	2.35	high_impact	0.33	0.8	28.86	7.2	0.76	P	0.89	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13058	13058	C	A	MI.20789	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	722	241	T	N	aCc/aAc	8.44	1	0	probably_damaging	1	neutral	0.31	neutral	4.47	deleterious	-4.89	deleterious	-4.46	high_impact	4.17	0.29	damaging	0.41	neutral	3.64	23.20	deleterious	0.52	0.6	0.84	disease	0.48	neutral	0.71	disease	0.67	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.75	deleterious	-3.6	low_impact	0.04	medium_impact	2.61	high_impact	0.48	0.8	28.86	7.2	0.92	P	0.93	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6001	6001	T	A	MI.2079	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	98	33	L	Q	cTa/cAa	-1.26	0	0	possibly_damaging	0.88	deleterious	0	neutral	2.55	deleterious	-3.33	deleterious	-2.65	high_impact	4.26	0.57	damaging	0.42	neutral	3.76	23.30	deleterious	0.16	0.55	0.5	neutral	0.76	disease	0.56	disease	0.67	disease	3	1	deleterious	0.06	neutral	5	deleterious	0.69	deleterious	-1.57	low_impact	-1.48	low_impact	2.83	high_impact	0.62	0.9	10.14	39.34	0.42	N	0.82	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13058	13058	C	T	MI.20790	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	722	241	T	I	aCc/aTc	8.44	1	0	probably_damaging	1	neutral	0.41	neutral	4.5	deleterious	-5.53	deleterious	-5.35	high_impact	4.41	0.35	damaging	0.49	neutral	3.97	23.60	deleterious	0.4	0.5	0.75	disease	0.58	disease	0.7	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.15	medium_impact	2.83	high_impact	0.38	0.8	28.86	7.2	0.75	P	0.95	disease_causing	1	0.28	.	.	.	.	.	.	COSM6716781	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13060	13060	C	A	MI.20791	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	724	242	P	T	Cca/Aca	-11.74	0	0	probably_damaging	1	neutral	0.44	neutral	4.55	deleterious	-3.96	deleterious	-7.21	high_impact	3.98	0.32	damaging	0.3	neutral	3.70	23.30	deleterious	0.45	0.55	0.77	disease	0.58	disease	0.73	disease	0.71	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.18	medium_impact	2.43	high_impact	0.79	0.85	27.2	7.25	0.55	P	0.91	disease_causing	0.64	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13060	13060	C	G	MI.20792	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	724	242	P	A	Cca/Gca	-11.74	0	0	probably_damaging	1	neutral	0.57	neutral	4.45	neutral	-2.78	deleterious	-7.21	high_impact	4.54	0.32	damaging	0.43	neutral	3.05	22.40	deleterious	0.5	0.6	0.66	disease	0.38	neutral	0.75	disease	0.63	disease	3	1	deleterious	0.29	neutral	2	deleterious	0.74	deleterious	-3.6	low_impact	0.3	medium_impact	2.94	high_impact	0.78	0.85	27.2	7.25	0.68	P	0.73	disease_causing	0.53	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13060	13060	C	T	MI.20793	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	724	242	P	S	Cca/Tca	-11.74	0	0	probably_damaging	1	neutral	0.47	neutral	4.4	deleterious	-3.79	deleterious	-7.21	high_impact	4.13	0.35	damaging	0.4	neutral	3.89	23.50	deleterious	0.55	0.6	0.66	disease	0.62	disease	0.73	disease	0.7	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.2	medium_impact	2.57	high_impact	0.34	0.8	27.2	7.25	0.57	P	0.78	disease_causing	0.65	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13061	13061	C	T	MI.20794	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	725	242	P	L	cCa/cTa	7.07	1	0	probably_damaging	1	neutral	0.7	neutral	4.52	deleterious	-4.96	deleterious	-9.01	high_impact	5.23	0.25	damaging	0.34	neutral	4.36	24.10	deleterious	0.52	0.6	0.7	disease	0.62	disease	0.72	disease	0.68	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.44	medium_impact	3.57	high_impact	0.72	0.85	27.2	7.25	0.87	P	0.97	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13061	13061	C	A	MI.20795	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	725	242	P	Q	cCa/cAa	7.07	1	0	probably_damaging	1	neutral	0.31	neutral	4.37	deleterious	-4.96	deleterious	-7.21	high_impact	5.23	0.36	damaging	0.33	neutral	4.06	23.70	deleterious	0.33	0.5	0.91	disease	0.7	disease	0.74	disease	0.71	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.04	medium_impact	3.57	high_impact	0.76	0.85	27.2	7.25	0.79	P	0.85	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13061	13061	C	G	MI.20796	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	725	242	P	R	cCa/cGa	7.07	1	0	probably_damaging	1	neutral	0.36	neutral	4.38	deleterious	-5.34	deleterious	-8.11	high_impact	4.88	0.36	damaging	0.31	neutral	3.56	23.10	deleterious	0.38	0.5	0.93	disease	0.66	disease	0.82	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.1	medium_impact	3.26	high_impact	0.59	0.8	27.2	7.25	0.78	P	0.64	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13063	13063	G	A	MI.20797	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	727	243	V	I	Gtc/Atc	-9.22	0	0	probably_damaging	1	neutral	0.44	neutral	4.51	neutral	-2.91	neutral	-0.9	medium_impact	3.17	0.37	damaging	0.12	damaging	3.60	23.20	deleterious	0.71	0.75	0.71	disease	0.3	neutral	0.63	disease	0.55	disease	1	1	deleterious	0.22	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.18	medium_impact	1.69	medium_impact	0.91	0.95	27.53	7.23	0.63	P	0.44	polymorphism	0.94	0.06	.	.	.	.	.	.	COSM488739	.	.	G13063A	Adult-onset Encephalopathy / Ataxia	-	+	Reported	3	.	P	P	damaging
chrM	13063	13063	G	T	MI.20798	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	727	243	V	F	Gtc/Ttc	-9.22	0	0	probably_damaging	1	neutral	0.74	neutral	4.4	deleterious	-4.96	deleterious	-4.51	high_impact	4.82	0.33	damaging	0.1	damaging	3.83	23.40	deleterious	0.28	0.45	0.86	disease	0.67	disease	0.72	disease	0.7	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.48	medium_impact	3.2	high_impact	0.79	0.85	27.53	7.23	0.6	P	0.95	disease_causing	0.71	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13063	13063	G	C	MI.20799	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	727	243	V	L	Gtc/Ctc	-9.22	0	0	probably_damaging	1	neutral	0.86	neutral	4.5	deleterious	-4.21	deleterious	-2.7	high_impact	5.17	0.32	damaging	0.09	damaging	3.60	23.20	deleterious	0.55	0.6	0.81	disease	0.39	neutral	0.68	disease	0.61	disease	2	1	deleterious	0.43	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.67	medium_impact	3.52	high_impact	0.73	0.85	27.53	7.23	0.62	P	0.77	polymorphism	0.82	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8623	8623	A	C	MI.208	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	97	33	T	P	Acc/Ccc	-15.14	0	0	benign	0.28	neutral	0.24	neutral	4.22	neutral	-2.04	neutral	-1.57	low_impact	1.72	0.93	neutral	0.7	neutral	1.10	11.19	neutral	0.34	0.65	0.36	neutral	0.76	disease	0.48	neutral	0.54	disease	1	0.71	neutral	0.48	deleterious	-6	neutral	0.44	deleterious	-0.37	medium_impact	0.01	medium_impact	0.38	medium_impact	0.54	0.9	19.47	19.69	0.36	N	0.99	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6001	6001	T	G	MI.2080	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	98	33	L	R	cTa/cGa	-1.26	0	0	possibly_damaging	0.88	deleterious	0	neutral	2.54	deleterious	-3.58	deleterious	-2.8	high_impact	4.62	0.55	damaging	0.3	neutral	3.89	23.50	deleterious	0.14	0.55	0.41	neutral	0.86	disease	0.69	disease	0.75	disease	5	1	deleterious	0.06	neutral	5	deleterious	0.75	deleterious	-1.57	low_impact	-1.48	low_impact	3.17	high_impact	0.67	0.9	10.14	39.34	0.49	N	0.90	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13064	13064	T	C	MI.20800	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	728	243	V	A	gTc/gCc	5.92	1	0	probably_damaging	1	neutral	0.56	neutral	4.49	deleterious	-3.42	deleterious	-3.6	high_impact	3.69	0.28	damaging	0.14	damaging	3.57	23.20	deleterious	0.66	0.7	0.77	disease	0.31	neutral	0.7	disease	0.58	disease	2	1	deleterious	0.28	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.29	medium_impact	2.17	high_impact	0.58	0.8	27.53	7.23	0.9	P	0.52	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13064	13064	T	A	MI.20801	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	728	243	V	D	gTc/gAc	5.92	1	0	probably_damaging	1	neutral	0.23	neutral	4.39	deleterious	-8	deleterious	-6.31	high_impact	5.17	0.45	damaging	0.1	damaging	4.64	24.50	deleterious	0.14	0.4	0.97	disease	0.69	disease	0.8	disease	0.8	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.06	medium_impact	3.52	high_impact	0.75	0.85	27.53	7.23	0.68	P	0.93	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13064	13064	T	G	MI.20802	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	728	243	V	G	gTc/gGc	5.92	1	0	probably_damaging	1	neutral	0.38	neutral	4.43	deleterious	-3.67	deleterious	-6.31	high_impact	4.82	0.34	damaging	0.13	damaging	3.78	23.40	deleterious	0.27	0.45	0.73	disease	0.51	disease	0.71	disease	0.7	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.12	medium_impact	3.2	high_impact	0.68	0.85	27.53	7.23	0.79	P	0.89	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13066	13066	T	A	MI.20803	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	730	244	S	T	Tca/Aca	-9.45	0	0	probably_damaging	1	neutral	0.43	neutral	4.47	deleterious	-3.23	deleterious	-2.7	high_impact	4.88	0.32	damaging	0.34	neutral	3.71	23.30	deleterious	0.3	0.45	0.56	disease	0.45	neutral	0.7	disease	0.58	disease	2	1	deleterious	0.22	neutral	2	deleterious	0.75	deleterious	-3.6	low_impact	0.17	medium_impact	3.26	high_impact	0.84	0.9	29.52	7.21	0.73	P	0.71	polymorphism	0.97	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13066	13066	T	C	MI.20804	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	730	244	S	P	Tca/Cca	-9.45	0	0	probably_damaging	1	neutral	0.23	neutral	4.39	deleterious	-7.26	deleterious	-4.51	high_impact	5.24	0.25	damaging	0.42	neutral	3.96	23.60	deleterious	0.25	0.45	0.96	disease	0.59	disease	0.82	disease	0.75	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.06	medium_impact	3.58	high_impact	0.70	0.85	29.52	7.21	0.89	P	0.98	polymorphism	0.84	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13066	13066	T	G	MI.20805	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	730	244	S	A	Tca/Gca	-9.45	0	0	probably_damaging	1	neutral	0.56	neutral	4.46	deleterious	-4.38	deleterious	-2.7	high_impact	3.95	0.33	damaging	0.46	neutral	3.67	23.30	deleterious	0.35	0.5	0.76	disease	0.34	neutral	0.69	disease	0.59	disease	2	1	deleterious	0.28	neutral	2	deleterious	0.75	deleterious	-3.6	low_impact	0.29	medium_impact	2.41	high_impact	0.82	0.85	29.52	7.21	0.6	P	0.49	polymorphism	0.99	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13067	13067	C	G	MI.20806	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	731	244	S	W	tCa/tGa	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	4.38	deleterious	-8.65	deleterious	-6.31	high_impact	5.24	0.31	damaging	0.41	neutral	4.34	24.00	deleterious	0.13	0.4	0.98	disease	0.66	disease	0.76	disease	0.78	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.12	medium_impact	3.58	high_impact	0.42	0.8	29.52	7.21	0.77	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13067	13067	C	T	MI.20807	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	731	244	S	L	tCa/tTa	7.3	1	0	probably_damaging	1	neutral	0.76	neutral	4.43	deleterious	-4.84	deleterious	-5.41	high_impact	4.88	0.21	damaging	0.36	neutral	4.65	24.50	deleterious	0.25	0.45	0.85	disease	0.61	disease	0.69	disease	0.71	disease	4	1	deleterious	0.38	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.51	medium_impact	3.26	high_impact	0.85	0.9	29.52	7.21	0.93	P	0.99	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13069	13069	G	A	MI.20808	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	733	245	A	T	Gcc/Acc	-0.5	0.23	0	probably_damaging	1	neutral	0.4	neutral	4.45	deleterious	-4.6	deleterious	-3.6	high_impact	3.65	0.42	damaging	0.11	damaging	4.18	23.80	deleterious	0.28	0.45	0.63	disease	0.66	disease	0.67	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.14	medium_impact	2.13	high_impact	0.68	0.85	28.69	7.21	0.45	N	0.94	disease_causing	1	0.27	.	.	.	.	.	.	COSM488740	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13069	13069	G	T	MI.20809	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	733	245	A	S	Gcc/Tcc	-0.5	0.23	0	probably_damaging	1	neutral	0.44	neutral	4.7	deleterious	-4.15	deleterious	-2.7	low_impact	1.7	0.51	damaging	0.1	damaging	3.66	23.20	deleterious	0.3	0.45	0.76	disease	0.66	disease	0.56	disease	0.56	disease	1	1	deleterious	0.22	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.18	medium_impact	0.35	medium_impact	0.75	0.85	28.69	7.21	0.25	N	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6003	6003	A	T	MI.2081	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	100	34	S	C	Agc/Tgc	-11.67	0	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-5.22	deleterious	-2.88	high_impact	5.05	0.46	damaging	0.02	damaging	3.24	22.80	deleterious	0.24	0.55	0.88	disease	0.77	disease	0.62	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.71	0.9	2.92	6.65	0.56	P	0.85	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13069	13069	G	C	MI.20810	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	733	245	A	P	Gcc/Ccc	-0.5	0.23	0	probably_damaging	1	neutral	0.22	neutral	4.34	deleterious	-7.04	deleterious	-4.51	high_impact	5.08	0.43	damaging	0.1	damaging	3.80	23.40	deleterious	0.16	0.45	0.94	disease	0.69	disease	0.79	disease	0.81	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.07	medium_impact	3.44	high_impact	0.62	0.8	28.69	7.21	0.72	P	0.96	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13070	13070	C	A	MI.20811	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	734	245	A	D	gCc/gAc	7.07	1	0	probably_damaging	1	neutral	0.21	neutral	4.35	deleterious	-7.81	deleterious	-5.41	high_impact	5.08	0.52	damaging	0.09	damaging	4.58	24.40	deleterious	0.11	0.4	0.97	disease	0.81	disease	0.78	disease	0.81	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.09	medium_impact	3.44	high_impact	0.66	0.8	28.69	7.21	0.69	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13070	13070	C	T	MI.20812	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	734	245	A	V	gCc/gTc	7.07	1	0	probably_damaging	1	neutral	0.52	neutral	4.41	deleterious	-3.27	deleterious	-3.6	high_impact	4.53	0.44	damaging	0.06	damaging	4.39	24.10	deleterious	0.35	0.5	0.7	disease	0.69	disease	0.69	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.25	medium_impact	2.94	high_impact	0.71	0.85	28.69	7.21	0.67	P	0.76	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13070	13070	C	G	MI.20813	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	734	245	A	G	gCc/gGc	7.07	1	0	probably_damaging	1	neutral	0.36	neutral	4.45	deleterious	-4.64	deleterious	-3.6	high_impact	4.27	0.44	damaging	0.12	damaging	3.93	23.50	deleterious	0.21	0.45	0.92	disease	0.57	disease	0.67	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.1	medium_impact	2.7	high_impact	0.79	0.85	28.69	7.21	0.69	P	0.82	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13072	13072	C	A	MI.20814	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	736	246	L	M	Cta/Ata	-2.11	0	0	probably_damaging	1	neutral	0.26	neutral	4.37	deleterious	-3.35	neutral	-1.8	high_impact	4.21	0.45	damaging	0.14	damaging	3.70	23.30	deleterious	0.29	0.45	0.84	disease	0.49	neutral	0.64	disease	0.63	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	-0.02	medium_impact	2.64	high_impact	0.70	0.85	27.2	7.27	0.46	N	0.89	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13072	13072	C	G	MI.20815	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	736	246	L	V	Cta/Gta	-2.11	0	0	probably_damaging	1	neutral	0.55	neutral	4.33	neutral	-2.36	deleterious	-2.7	high_impact	4.3	0.35	damaging	0.11	damaging	3.37	22.90	deleterious	0.32	0.5	0.75	disease	0.55	disease	0.67	disease	0.66	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.28	medium_impact	2.73	high_impact	0.62	0.8	27.2	7.27	0.51	P	0.81	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13073	13073	T	C	MI.20816	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	737	246	L	P	cTa/cCa	-0.04	0	0	probably_damaging	1	neutral	0.31	neutral	4.21	deleterious	-5.71	deleterious	-6.31	high_impact	4.76	0.35	damaging	0.09	damaging	3.83	23.40	deleterious	0.17	0.45	0.96	disease	0.69	disease	0.77	disease	0.8	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.04	medium_impact	3.15	high_impact	0.62	0.8	27.2	7.27	0.64	P	0.99	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13073	13073	T	G	MI.20817	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	737	246	L	R	cTa/cGa	-0.04	0	0	probably_damaging	1	neutral	0.34	neutral	4.22	deleterious	-6.26	deleterious	-5.41	high_impact	4.76	0.41	damaging	0.08	damaging	4.14	23.80	deleterious	0.13	0.4	0.95	disease	0.79	disease	0.78	disease	0.83	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.07	medium_impact	3.15	high_impact	0.44	0.8	27.2	7.27	0.63	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13073	13073	T	A	MI.20818	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	737	246	L	Q	cTa/cAa	-0.04	0	0	probably_damaging	1	neutral	0.3	neutral	4.21	deleterious	-6.13	deleterious	-5.41	high_impact	5.11	0.38	damaging	0.09	damaging	3.99	23.60	deleterious	0.16	0.45	0.95	disease	0.75	disease	0.67	disease	0.8	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.03	medium_impact	3.47	high_impact	0.55	0.8	27.2	7.27	0.57	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	COSM6716796	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13075	13075	C	G	MI.20819	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	739	247	L	V	Ctc/Gtc	3.63	1	0	probably_damaging	1	neutral	0.51	neutral	4.36	deleterious	-3.72	deleterious	-2.7	medium_impact	2.02	0.52	damaging	0.09	damaging	3.39	23.00	deleterious	0.34	0.5	0.73	disease	0.49	neutral	0.68	disease	0.59	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.24	medium_impact	0.64	medium_impact	0.72	0.85	25.04	7.23	0.39	N	0.81	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6003	6003	A	G	MI.2082	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	100	34	S	G	Agc/Ggc	-11.67	0	0	probably_damaging	0.98	deleterious	0	neutral	3.19	neutral	0.63	neutral	-2.3	high_impact	4.5	0.48	damaging	0.08	damaging	3.41	23.00	deleterious	0.32	0.55	0.49	neutral	0.64	disease	0.63	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.35	low_impact	-1.48	low_impact	3.06	high_impact	0.68	0.9	2.92	6.65	0.42	N	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13075	13075	C	T	MI.20820	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	739	247	L	F	Ctc/Ttc	3.63	1	0	probably_damaging	1	neutral	0.66	neutral	4.35	deleterious	-3.64	deleterious	-3.6	high_impact	4.34	0.53	damaging	0.09	damaging	3.94	23.60	deleterious	0.37	0.5	0.81	disease	0.6	disease	0.61	disease	0.66	disease	3	1	deleterious	0.33	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.39	medium_impact	2.76	high_impact	0.56	0.8	25.04	7.23	0.43	N	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13075	13075	C	A	MI.20821	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	739	247	L	I	Ctc/Atc	3.63	1	0	probably_damaging	1	neutral	0.41	neutral	4.63	neutral	-1.24	neutral	-1.8	medium_impact	1.98	0.61	neutral	0.19	damaging	4.06	23.70	deleterious	0.31	0.45	0.6	disease	0.26	neutral	0.66	disease	0.54	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.15	medium_impact	0.61	medium_impact	0.68	0.85	25.04	7.23	0.48	N	0.85	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13076	13076	T	A	MI.20822	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	740	247	L	H	cTc/cAc	0.87	1	0	probably_damaging	1	neutral	0.5	neutral	4.2	deleterious	-7.03	deleterious	-6.31	high_impact	4.69	0.54	damaging	0.09	damaging	4.26	23.90	deleterious	0.16	0.45	0.92	disease	0.72	disease	0.75	disease	0.8	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.23	medium_impact	3.08	high_impact	0.55	0.8	25.04	7.23	0.52	P	0.97	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13076	13076	T	G	MI.20823	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	740	247	L	R	cTc/cGc	0.87	1	0	probably_damaging	1	neutral	0.29	neutral	4.2	deleterious	-6.51	deleterious	-5.41	high_impact	4.69	0.54	damaging	0.09	damaging	4.14	23.80	deleterious	0.13	0.4	0.87	disease	0.77	disease	0.78	disease	0.76	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.02	medium_impact	3.08	high_impact	0.46	0.8	25.04	7.23	0.57	P	1.00	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13076	13076	T	C	MI.20824	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	740	247	L	P	cTc/cCc	0.87	1	0	probably_damaging	1	neutral	0.23	neutral	4.2	deleterious	-6.96	deleterious	-6.31	high_impact	4.69	0.48	damaging	0.1	damaging	3.91	23.50	deleterious	0.14	0.4	0.96	disease	0.71	disease	0.78	disease	0.82	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.06	medium_impact	3.08	high_impact	0.68	0.85	25.04	7.23	0.55	P	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13078	13078	C	T	MI.20825	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	742	248	H	Y	Cac/Tac	-20	0	0	probably_damaging	1	neutral	1	neutral	4.43	deleterious	-4.43	deleterious	-5.41	high_impact	4.51	0.43	damaging	0.09	damaging	3.64	23.20	deleterious	0.32	0.5	0.71	disease	0.78	disease	0.77	disease	0.71	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.83	deleterious	-3.6	low_impact	1.89	high_impact	2.92	high_impact	0.49	0.8	29.85	7.2	0.43	N	1.00	polymorphism	0.75	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13078	13078	C	A	MI.20826	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	742	248	H	N	Cac/Aac	-20	0	0	probably_damaging	1	neutral	0.31	neutral	4.42	deleterious	-5.4	deleterious	-6.31	high_impact	5.21	0.35	damaging	0.11	damaging	3.83	23.40	deleterious	0.32	0.5	0.96	disease	0.71	disease	0.74	disease	0.71	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.04	medium_impact	3.56	high_impact	0.65	0.8	29.85	7.2	0.48	N	0.97	polymorphism	0.79	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13078	13078	C	G	MI.20827	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	742	248	H	D	Cac/Gac	-20	0	0	probably_damaging	1	neutral	0.21	neutral	4.42	deleterious	-5.59	deleterious	-8.11	high_impact	4.51	0.48	damaging	0.11	damaging	3.80	23.40	deleterious	0.22	0.45	0.98	disease	0.78	disease	0.81	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.09	medium_impact	2.92	high_impact	0.62	0.8	29.85	7.2	0.42	N	0.97	polymorphism	0.53	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13079	13079	A	T	MI.20828	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	743	248	H	L	cAc/cTc	7.07	1	0	probably_damaging	1	neutral	0.77	neutral	4.85	neutral	-2.83	deleterious	-9.91	high_impact	5.21	0.35	damaging	0.09	damaging	3.78	23.40	deleterious	0.27	0.45	0.51	disease	0.8	disease	0.73	disease	0.7	disease	4	1	deleterious	0.39	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.52	medium_impact	3.56	high_impact	0.49	0.8	29.85	7.2	0.7	P	0.97	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13079	13079	A	C	MI.20829	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	743	248	H	P	cAc/cCc	7.07	1	0	probably_damaging	1	neutral	0.26	neutral	4.42	deleterious	-5.82	deleterious	-9.01	high_impact	4.86	0.41	damaging	0.13	damaging	3.15	22.60	deleterious	0.28	0.45	0.98	disease	0.8	disease	0.83	disease	0.76	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.02	medium_impact	3.24	high_impact	0.47	0.8	29.85	7.2	0.74	P	0.97	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6003	6003	A	C	MI.2083	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	100	34	S	R	Agc/Cgc	-11.67	0	0	probably_damaging	1	deleterious	0.02	neutral	2.6	deleterious	-5.14	deleterious	-2.87	high_impact	4.5	0.5	damaging	0.02	damaging	3.66	23.20	deleterious	0.15	0.55	0.89	disease	0.85	disease	0.75	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-0.75	medium_impact	3.06	high_impact	0.72	0.9	2.92	6.65	0.4	N	0.98	polymorphism	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13079	13079	A	G	MI.20830	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	743	248	H	R	cAc/cGc	7.07	1	0	probably_damaging	1	neutral	0.35	neutral	4.43	deleterious	-4.68	deleterious	-7.21	medium_impact	3.31	0.48	damaging	0.1	damaging	2.93	22.00	deleterious	0.38	0.5	0.97	disease	0.78	disease	0.75	disease	0.72	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	0.08	medium_impact	1.82	medium_impact	0.60	0.8	29.85	7.2	0.48	N	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13080	13080	C	G	MI.20831	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	744	248	H	Q	caC/caG	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	4.43	deleterious	-4.84	deleterious	-7.21	high_impact	5.21	0.44	damaging	0.09	damaging	3.51	23.10	deleterious	0.36	0.5	0.97	disease	0.74	disease	0.75	disease	0.72	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.03	medium_impact	3.56	high_impact	0.65	0.8	29.85	7.2	0.68	P	0.95	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13080	13080	C	A	MI.20832	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	744	248	H	Q	caC/caA	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	4.43	deleterious	-4.84	deleterious	-7.21	high_impact	5.21	0.44	damaging	0.09	damaging	3.73	23.30	deleterious	0.36	0.5	0.97	disease	0.74	disease	0.75	disease	0.72	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.03	medium_impact	3.56	high_impact	0.65	0.8	29.85	7.2	0.68	P	0.95	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13081	13081	T	G	MI.20833	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	745	249	S	A	Tca/Gca	-0.04	0.85	0	probably_damaging	1	neutral	0.51	neutral	4.88	neutral	0.84	deleterious	-2.7	medium_impact	2.11	0.52	damaging	0.22	damaging	3.64	23.20	deleterious	0.32	0.5	0.44	neutral	0.26	neutral	0.67	disease	0.43	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.70	deleterious	-3.6	low_impact	0.24	medium_impact	0.73	medium_impact	0.68	0.85	29.52	7.27	0.36	N	0.49	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13081	13081	T	A	MI.20834	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	745	249	S	T	Tca/Aca	-0.04	0.85	0	probably_damaging	1	neutral	0.39	neutral	4.44	neutral	-2.44	deleterious	-2.7	high_impact	4.59	0.51	damaging	0.04	damaging	3.87	23.50	deleterious	0.23	0.45	0.85	disease	0.55	disease	0.71	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.13	medium_impact	2.99	high_impact	0.62	0.8	29.52	7.27	0.45	N	0.71	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13081	13081	T	C	MI.20835	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	745	249	S	P	Tca/Cca	-0.04	0.85	0	probably_damaging	1	neutral	0.2	neutral	4.4	deleterious	-4.87	deleterious	-4.51	high_impact	4.59	0.51	damaging	0.06	damaging	3.97	23.60	deleterious	0.21	0.45	0.97	disease	0.75	disease	0.81	disease	0.78	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.1	medium_impact	2.99	high_impact	0.65	0.8	29.52	7.27	0.56	P	0.98	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13082	13082	C	G	MI.20836	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	746	249	S	W	tCa/tGa	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	4.39	deleterious	-6.71	deleterious	-6.31	high_impact	4.94	0.55	damaging	0.04	damaging	4.28	24.00	deleterious	0.1	0.4	1	disease	0.81	disease	0.75	disease	0.79	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.12	medium_impact	3.31	high_impact	0.37	0.8	29.52	7.27	0.64	P	0.99	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13082	13082	C	T	MI.20837	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	746	249	S	L	tCa/tTa	7.3	1	0	probably_damaging	1	neutral	0.66	neutral	4.47	deleterious	-3.04	deleterious	-5.41	high_impact	4.94	0.49	damaging	0.03	damaging	4.59	24.40	deleterious	0.16	0.45	0.94	disease	0.75	disease	0.69	disease	0.71	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.39	medium_impact	3.31	high_impact	0.68	0.85	29.52	7.27	0.67	P	0.99	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13084	13084	A	C	MI.20838	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	748	250	S	R	Agc/Cgc	-8.53	0	0	probably_damaging	1	neutral	0.35	neutral	4.54	neutral	-2.99	deleterious	-4.51	high_impact	4.81	0.55	damaging	0.04	damaging	3.81	23.40	deleterious	0.21	0.45	0.63	disease	0.84	disease	0.77	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.08	medium_impact	3.19	high_impact	0.61	0.8	26.87	7.22	0.66	P	0.99	polymorphism	0.53	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13084	13084	A	G	MI.20839	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	748	250	S	G	Agc/Ggc	-8.53	0	0	probably_damaging	1	neutral	0.34	neutral	4.68	neutral	1.61	deleterious	-3.6	high_impact	4.81	0.51	damaging	0.09	damaging	3.56	23.10	deleterious	0.48	0.55	0.39	neutral	0.65	disease	0.67	disease	0.66	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.70	deleterious	-3.6	low_impact	0.07	medium_impact	3.19	high_impact	0.65	0.8	26.87	7.22	0.62	P	0.86	polymorphism	0.85	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6004	6004	G	C	MI.2084	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	101	34	S	T	aGc/aCc	8.69	1	0	probably_damaging	0.95	deleterious	0	neutral	2.61	deleterious	-4.06	neutral	-1.72	high_impact	4.71	0.5	damaging	0.04	damaging	3.21	22.70	deleterious	0.31	0.55	0.69	disease	0.6	disease	0.64	disease	0.59	disease	2	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-1.96	low_impact	-1.48	low_impact	3.25	high_impact	0.84	0.9	2.92	6.65	0.68	P	0.43	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13084	13084	A	T	MI.20840	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	748	250	S	C	Agc/Tgc	-8.53	0	0	probably_damaging	1	neutral	0.18	neutral	4.52	neutral	-2.52	deleterious	-4.51	high_impact	4.81	0.51	damaging	0.02	damaging	3.42	23.00	deleterious	0.25	0.45	0.95	disease	0.76	disease	0.65	disease	0.76	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.13	medium_impact	3.19	high_impact	0.55	0.8	26.87	7.22	0.61	P	0.99	disease_causing_automatic	0.42	0.34	rs267606896	Pathogenic	Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency	24740	MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003|MedGen:C1838951	.	.	.	.	A13084T	MELAS / Leigh Disease	-	+	Reported	4	P	P	P	damaging
chrM	13085	13085	G	A	MI.20841	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	749	250	S	N	aGc/aAc	6.61	1	0	probably_damaging	1	neutral	0.31	neutral	4.54	deleterious	-3.1	deleterious	-2.7	high_impact	4.81	0.51	damaging	0.03	damaging	3.58	23.20	deleterious	0.44	0.55	0.56	disease	0.68	disease	0.67	disease	0.66	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.04	medium_impact	3.19	high_impact	0.38	0.8	26.87	7.22	0.74	P	0.87	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13085	13085	G	C	MI.20842	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	749	250	S	T	aGc/aCc	6.61	1	0	probably_damaging	1	neutral	0.42	neutral	4.72	neutral	-0.97	deleterious	-2.7	high_impact	4.12	0.51	damaging	0.05	damaging	3.36	22.90	deleterious	0.36	0.5	0.64	disease	0.59	disease	0.65	disease	0.64	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.16	medium_impact	2.56	high_impact	0.76	0.85	26.87	7.22	0.55	P	0.71	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13085	13085	G	T	MI.20843	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	749	250	S	I	aGc/aTc	6.61	1	0	probably_damaging	1	neutral	0.41	neutral	4.66	neutral	-0.26	deleterious	-5.41	high_impact	4.81	0.48	damaging	0.04	damaging	4.06	23.70	deleterious	0.22	0.45	0.66	disease	0.88	disease	0.67	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.15	medium_impact	3.19	high_impact	0.72	0.85	26.87	7.22	0.69	P	0.99	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13087	13087	A	G	MI.20844	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	751	251	T	A	Act/Gct	-0.73	0.04	0	probably_damaging	1	neutral	1	neutral	4.5	neutral	-2.45	deleterious	-4.51	medium_impact	3.15	0.42	damaging	0.13	damaging	3.42	23.00	deleterious	0.69	0.75	0.72	disease	0.59	disease	0.61	disease	0.63	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.74	deleterious	-3.6	low_impact	1.89	high_impact	1.67	medium_impact	0.63	0.8	29.19	7.28	0.41	N	0.69	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13087	13087	A	C	MI.20845	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	751	251	T	P	Act/Cct	-0.73	0.04	0	probably_damaging	1	neutral	0.28	neutral	4.38	deleterious	-3.66	deleterious	-5.41	high_impact	5.18	0.43	damaging	0.11	damaging	3.47	23.00	deleterious	0.21	0.45	0.91	disease	0.78	disease	0.78	disease	0.75	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.01	medium_impact	3.53	high_impact	0.70	0.85	29.19	7.28	0.72	P	0.97	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13087	13087	A	T	MI.20846	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	751	251	T	S	Act/Tct	-0.73	0.04	0	probably_damaging	1	neutral	0.87	neutral	4.41	neutral	-2.95	deleterious	-3.6	high_impact	4.38	0.46	damaging	0.1	damaging	3.28	22.80	deleterious	0.35	0.5	0.79	disease	0.7	disease	0.63	disease	0.67	disease	3	1	deleterious	0.44	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.69	medium_impact	2.8	high_impact	0.72	0.85	29.19	7.28	0.37	N	0.89	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13088	13088	C	A	MI.20847	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	752	251	T	N	aCt/aAt	6.61	1	0	probably_damaging	1	neutral	0.48	neutral	4.38	deleterious	-5.6	deleterious	-4.51	high_impact	5.18	0.37	damaging	0.09	damaging	3.54	23.10	deleterious	0.5	0.6	0.95	disease	0.75	disease	0.7	disease	0.71	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.21	medium_impact	3.53	high_impact	0.83	0.9	29.19	7.28	0.7	P	0.93	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13088	13088	C	G	MI.20848	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	752	251	T	S	aCt/aGt	6.61	1	0	probably_damaging	1	neutral	0.87	neutral	4.41	neutral	-2.95	deleterious	-3.6	high_impact	4.38	0.46	damaging	0.1	damaging	3.44	23.00	deleterious	0.35	0.5	0.79	disease	0.7	disease	0.63	disease	0.67	disease	3	1	deleterious	0.44	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.69	medium_impact	2.8	high_impact	0.72	0.85	29.19	7.28	0.53	P	0.89	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13088	13088	C	T	MI.20849	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	752	251	T	I	aCt/aTt	6.61	1	0	probably_damaging	1	neutral	0.32	neutral	4.55	neutral	-2.44	deleterious	-5.41	high_impact	4.63	0.4	damaging	0.1	damaging	3.83	23.40	deleterious	0.49	0.55	0.55	disease	0.85	disease	0.66	disease	0.71	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.75	deleterious	-3.6	low_impact	0.05	medium_impact	3.03	high_impact	0.74	0.85	29.19	7.28	0.7	P	0.95	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6004	6004	G	A	MI.2085	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	101	34	S	N	aGc/aAc	8.69	1	0	probably_damaging	0.95	deleterious	0	neutral	2.61	deleterious	-4.04	neutral	-1.73	high_impact	5.05	0.42	damaging	0.04	damaging	3.49	23.10	deleterious	0.52	0.6	0.83	disease	0.77	disease	0.64	disease	0.74	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-1.96	low_impact	-1.48	low_impact	3.56	high_impact	0.56	0.9	2.92	6.65	0.73	P	0.66	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13090	13090	A	G	MI.20850	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	754	252	M	V	Ata/Gta	-8.76	0	0	probably_damaging	0.99	neutral	0.49	neutral	4.6	neutral	-2.27	deleterious	-3.6	medium_impact	3.37	0.4	damaging	0.06	damaging	2.78	21.30	deleterious	0.62	0.65	0.55	disease	0.87	disease	0.69	disease	0.71	disease	4	0.99	deleterious	0.25	neutral	1	deleterious	0.74	deleterious	-2.64	low_impact	0.22	medium_impact	1.88	medium_impact	0.65	0.8	28.86	7.2	0.35	N	0.95	polymorphism	0.97	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13090	13090	A	T	MI.20851	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	754	252	M	L	Ata/Tta	-8.76	0	0	probably_damaging	0.98	neutral	1	neutral	5	neutral	-1.03	deleterious	-2.7	medium_impact	2.27	0.44	damaging	0.05	damaging	3.48	23.10	deleterious	0.54	0.6	0.45	neutral	0.83	disease	0.62	disease	0.56	disease	1	0.98	deleterious	0.51	deleterious	1	deleterious	0.68	deleterious	-2.35	low_impact	1.89	high_impact	0.87	medium_impact	0.62	0.8	28.86	7.2	0.3	N	0.98	polymorphism	0.98	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13090	13090	A	C	MI.20852	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	754	252	M	L	Ata/Cta	-8.76	0	0	probably_damaging	0.98	neutral	1	neutral	5	neutral	-1.03	deleterious	-2.7	medium_impact	2.27	0.44	damaging	0.05	damaging	3.29	22.80	deleterious	0.54	0.6	0.45	neutral	0.83	disease	0.62	disease	0.56	disease	1	0.98	deleterious	0.51	deleterious	1	deleterious	0.68	deleterious	-2.35	low_impact	1.89	high_impact	0.87	medium_impact	0.62	0.8	28.86	7.2	0.29	N	0.98	polymorphism	0.98	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13091	13091	T	A	MI.20853	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	755	252	M	K	aTa/aAa	5.46	1	0	probably_damaging	1	neutral	0.25	neutral	4.52	neutral	-2.68	deleterious	-5.41	high_impact	4.65	0.45	damaging	0.04	damaging	3.88	23.50	deleterious	0.19	0.45	0.92	disease	0.92	disease	0.77	disease	0.67	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.03	medium_impact	3.04	high_impact	0.48	0.8	28.86	7.2	0.7	P	1.00	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13091	13091	T	C	MI.20854	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	755	252	M	T	aTa/aCa	5.46	1	0	probably_damaging	1	neutral	0.49	neutral	4.55	deleterious	-4.18	deleterious	-5.41	high_impact	4.45	0.43	damaging	0.07	damaging	2.91	21.90	deleterious	0.47	0.55	0.59	disease	0.85	disease	0.7	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.22	medium_impact	2.86	high_impact	0.49	0.8	28.86	7.2	0.58	P	0.99	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13092	13092	A	T	MI.20855	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	756	252	M	I	atA/atT	5.69	1	0	probably_damaging	0.99	neutral	0.32	neutral	4.6	deleterious	-3.31	deleterious	-3.6	high_impact	4.3	0.41	damaging	0.07	damaging	3.48	23.10	deleterious	0.48	0.55	0.77	disease	0.88	disease	0.7	disease	0.71	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-2.64	low_impact	0.05	medium_impact	2.73	high_impact	0.73	0.85	28.86	7.2	0.72	P	0.94	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13092	13092	A	C	MI.20856	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	756	252	M	I	atA/atC	5.69	1	0	probably_damaging	0.99	neutral	0.32	neutral	4.6	deleterious	-3.31	deleterious	-3.6	high_impact	4.3	0.41	damaging	0.07	damaging	3.32	22.90	deleterious	0.48	0.55	0.77	disease	0.88	disease	0.7	disease	0.71	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-2.64	low_impact	0.05	medium_impact	2.73	high_impact	0.73	0.85	28.86	7.2	0.71	P	0.94	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13093	13093	G	A	MI.20857	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	757	253	V	I	Gtt/Att	1.1	1	0	probably_damaging	1	neutral	0.49	neutral	4.36	neutral	-1.53	neutral	-0.9	high_impact	5.25	0.43	damaging	0.11	damaging	3.60	23.20	deleterious	0.56	0.6	0.68	disease	0.72	disease	0.51	disease	0.54	disease	1	1	deleterious	0.25	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.22	medium_impact	3.59	high_impact	0.85	0.9	28.19	7.17	0.69	P	0.44	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13093	13093	G	C	MI.20858	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	757	253	V	L	Gtt/Ctt	1.1	1	0	probably_damaging	1	neutral	1	neutral	4.5	neutral	-0.63	deleterious	-2.7	high_impact	5.25	0.34	damaging	0.1	damaging	3.47	23.00	deleterious	0.43	0.55	0.54	disease	0.81	disease	0.55	disease	0.65	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.79	deleterious	-3.6	low_impact	1.89	high_impact	3.59	high_impact	0.66	0.8	28.19	7.17	0.67	P	0.77	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13093	13093	G	T	MI.20859	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	757	253	V	F	Gtt/Ttt	1.1	1	0	probably_damaging	1	neutral	0.7	neutral	4.21	deleterious	-4.21	deleterious	-4.51	high_impact	5.25	0.4	damaging	0.09	damaging	3.78	23.40	deleterious	0.22	0.45	0.9	disease	0.92	disease	0.63	disease	0.67	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.44	medium_impact	3.59	high_impact	0.70	0.85	28.19	7.17	0.64	P	0.95	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6004	6004	G	T	MI.2086	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	101	34	S	I	aGc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-5.95	deleterious	-3.45	high_impact	5.05	0.51	damaging	0.04	damaging	3.93	23.50	deleterious	0.22	0.55	0.9	disease	0.88	disease	0.65	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.71	0.9	2.92	6.65	0.68	P	0.96	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13094	13094	T	C	MI.20860	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	758	253	V	A	gTt/gCt	8.9	1	0	probably_damaging	1	neutral	0.62	neutral	4.23	deleterious	-3.48	deleterious	-3.6	high_impact	4.7	0.22	damaging	0.14	damaging	3.52	23.10	deleterious	0.46	0.55	0.81	disease	0.69	disease	0.58	disease	0.65	disease	3	1	deleterious	0.31	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.35	medium_impact	3.09	high_impact	0.52	0.8	28.19	7.17	0.89	P	0.52	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	T13094C	Ataxia+PEO / MELAS, LD, LHON, myoclonus, fatigue	+	+	Cfrm	6	.	P	P	damaging
chrM	13094	13094	T	A	MI.20861	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	758	253	V	D	gTt/gAt	8.9	1	0	probably_damaging	1	neutral	0.23	neutral	4.19	deleterious	-5.78	deleterious	-6.31	high_impact	5.25	0.53	damaging	0.1	damaging	4.46	24.20	deleterious	0.1	0.4	0.92	disease	0.92	disease	0.71	disease	0.65	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.06	medium_impact	3.59	high_impact	0.58	0.8	28.19	7.17	0.67	P	0.93	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13094	13094	T	G	MI.20862	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	758	253	V	G	gTt/gGt	8.9	1	0	probably_damaging	1	neutral	0.5	neutral	4.2	deleterious	-5.26	deleterious	-6.31	high_impact	5.25	0.38	damaging	0.14	damaging	3.79	23.40	deleterious	0.25	0.45	0.93	disease	0.86	disease	0.62	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.23	medium_impact	3.59	high_impact	0.48	0.8	28.19	7.17	0.76	P	0.89	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13096	13096	G	A	MI.20863	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	760	254	V	M	Gta/Ata	-14.95	0	0	probably_damaging	0.99	neutral	0.38	neutral	4.49	neutral	-1.68	neutral	-2.46	medium_impact	2.82	0.6	neutral	0.77	neutral	3.63	23.20	deleterious	0.58	0.65	0.81	disease	0.84	disease	0.52	disease	0.67	disease	3	0.99	deleterious	0.2	neutral	1	deleterious	0.78	deleterious	-2.64	low_impact	0.12	medium_impact	1.37	medium_impact	0.84	0.9	4.81	11.14	0.31	N	0.70	polymorphism	1	0.10	.	.	.	.	.	.	COSM6716785	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13096	13096	G	C	MI.20864	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	760	254	V	L	Gta/Cta	-14.95	0	0	possibly_damaging	0.76	neutral	0.74	neutral	4.59	neutral	-0.56	deleterious	-2.56	high_impact	4.06	0.55	damaging	0.47	neutral	3.48	23.10	deleterious	0.48	0.55	0.57	disease	0.84	disease	0.58	disease	0.68	disease	4	0.71	neutral	0.49	deleterious	1	deleterious	0.78	deleterious	-1.22	low_impact	0.48	medium_impact	2.51	high_impact	0.60	0.8	4.81	11.14	0.31	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13096	13096	G	T	MI.20865	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	760	254	V	L	Gta/Tta	-14.95	0	0	possibly_damaging	0.76	neutral	0.74	neutral	4.59	neutral	-0.56	deleterious	-2.56	high_impact	4.06	0.55	damaging	0.47	neutral	3.63	23.20	deleterious	0.48	0.55	0.57	disease	0.84	disease	0.58	disease	0.68	disease	4	0.71	neutral	0.49	deleterious	1	deleterious	0.78	deleterious	-1.22	low_impact	0.48	medium_impact	2.51	high_impact	0.60	0.8	4.81	11.14	0.31	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13097	13097	T	C	MI.20866	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	761	254	V	A	gTa/gCa	5	1	0	probably_damaging	0.92	neutral	0.66	neutral	4.55	neutral	0.72	deleterious	-3.53	low_impact	1.84	0.57	damaging	0.52	neutral	3.49	23.10	deleterious	0.58	0.65	0.51	disease	0.73	disease	0.58	disease	0.63	disease	3	0.91	neutral	0.37	neutral	-2	neutral	0.75	deleterious	-1.75	low_impact	0.39	medium_impact	0.48	medium_impact	0.62	0.8	4.81	11.14	0.43	N	0.75	disease_causing	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13097	13097	T	G	MI.20867	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	761	254	V	G	gTa/gGa	5	1	0	probably_damaging	0.99	neutral	0.4	neutral	4.47	neutral	-2.42	deleterious	-6.2	high_impact	3.51	0.55	damaging	0.54	neutral	3.77	23.40	deleterious	0.32	0.5	0.86	disease	0.89	disease	0.61	disease	0.68	disease	4	0.99	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-2.64	low_impact	0.14	medium_impact	2	high_impact	0.54	0.8	4.81	11.14	0.45	N	0.91	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13097	13097	T	A	MI.20868	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	761	254	V	E	gTa/gAa	5	1	0	probably_damaging	0.99	neutral	0.29	neutral	4.48	neutral	-2.34	deleterious	-5.3	high_impact	3.71	0.58	damaging	0.4	neutral	4.53	24.30	deleterious	0.24	0.45	0.83	disease	0.93	disease	0.72	disease	0.72	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-2.64	low_impact	0.02	medium_impact	2.19	high_impact	0.56	0.8	4.81	11.14	0.54	P	0.99	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13099	13099	G	A	MI.20869	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	763	255	A	T	Gca/Aca	-4.4	0	0	probably_damaging	1	neutral	0.44	neutral	4.25	deleterious	-3.88	deleterious	-3.6	high_impact	4.04	0.34	damaging	0.09	damaging	4.18	23.80	deleterious	0.5	0.6	0.73	disease	0.81	disease	0.66	disease	0.68	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.18	medium_impact	2.49	high_impact	0.77	0.85	28.36	7.18	0.48	N	0.94	disease_causing	0.62	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6006	6006	C	T	MI.2087	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	103	35	L	F	Ctc/Ttc	-1.26	0	0	benign	0.02	deleterious	0.04	neutral	2.44	neutral	-2.67	neutral	-1.58	low_impact	1.83	0.56	damaging	0.1	damaging	3.83	23.40	deleterious	0.38	0.55	0.59	disease	0.46	neutral	0.26	neutral	0.61	disease	2	0.96	neutral	0.51	deleterious	-2	neutral	0.23	neutral	0.83	medium_impact	-0.58	medium_impact	0.59	medium_impact	0.70	0.9	9.16	26.4	0.35	N	0.67	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13099	13099	G	T	MI.20870	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	763	255	A	S	Gca/Tca	-4.4	0	0	probably_damaging	1	neutral	0.49	neutral	4.23	deleterious	-4.48	deleterious	-2.7	medium_impact	3.36	0.46	damaging	0.11	damaging	3.66	23.20	deleterious	0.33	0.5	0.79	disease	0.83	disease	0.64	disease	0.68	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.22	medium_impact	1.87	medium_impact	0.82	0.85	28.36	7.18	0.3	N	0.98	polymorphism	0.58	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13099	13099	G	C	MI.20871	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	763	255	A	P	Gca/Cca	-4.4	0	0	probably_damaging	1	neutral	0.22	neutral	4.19	deleterious	-6.82	deleterious	-4.51	high_impact	5.2	0.44	damaging	0.09	damaging	3.77	23.40	deleterious	0.18	0.45	0.96	disease	0.87	disease	0.76	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.07	medium_impact	3.55	high_impact	0.70	0.85	28.36	7.18	0.6	P	0.96	disease_causing	0.85	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13100	13100	C	T	MI.20872	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	764	255	A	V	gCa/gTa	8.9	1	0	probably_damaging	1	neutral	0.55	neutral	4.31	neutral	-2.33	deleterious	-3.6	high_impact	4.16	0.34	damaging	0.06	damaging	4.37	24.10	deleterious	0.54	0.6	0.66	disease	0.88	disease	0.66	disease	0.71	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.28	medium_impact	2.6	high_impact	0.73	0.85	28.36	7.18	0.73	P	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13100	13100	C	G	MI.20873	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	764	255	A	G	gCa/gGa	8.9	1	0	probably_damaging	1	neutral	0.37	neutral	4.19	deleterious	-3.88	deleterious	-3.6	high_impact	4.39	0.4	damaging	0.12	damaging	3.87	23.50	deleterious	0.31	0.45	0.94	disease	0.81	disease	0.63	disease	0.73	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.11	medium_impact	2.81	high_impact	0.82	0.85	28.36	7.18	0.69	P	0.82	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13100	13100	C	A	MI.20874	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	764	255	A	E	gCa/gAa	8.9	1	0	probably_damaging	1	neutral	0.35	neutral	4.19	deleterious	-6.72	deleterious	-4.51	high_impact	5.2	0.46	damaging	0.09	damaging	4.45	24.20	deleterious	0.15	0.4	0.95	disease	0.9	disease	0.75	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.08	medium_impact	3.55	high_impact	0.69	0.85	28.36	7.18	0.71	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13102	13102	G	C	MI.20875	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	766	256	G	R	Gga/Cga	-3.03	0	0	probably_damaging	1	neutral	0.39	neutral	4.16	deleterious	-6.82	deleterious	-7.21	high_impact	5.23	0.43	damaging	0.08	damaging	3.91	23.50	deleterious	0.16	0.45	0.95	disease	0.89	disease	0.8	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.13	medium_impact	3.57	high_impact	0.83	0.9	28.19	7.18	0.58	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13102	13102	G	T	MI.20876	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	766	256	G	W	Gga/Tga	-3.03	0	0	probably_damaging	1	neutral	0.18	neutral	4.13	deleterious	-8.77	deleterious	-7.21	high_impact	5.23	0.5	damaging	0.06	damaging	4.37	24.10	deleterious	0.15	0.45	0.98	disease	0.9	disease	0.73	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.13	medium_impact	3.57	high_impact	0.46	0.8	28.19	7.18	0.46	N	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13103	13103	G	A	MI.20877	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	767	256	G	E	gGa/gAa	7.07	1	0	probably_damaging	1	neutral	0.36	neutral	4.18	deleterious	-6.88	deleterious	-7.21	high_impact	5.23	0.45	damaging	0.06	damaging	3.84	23.40	deleterious	0.17	0.45	0.94	disease	0.88	disease	0.8	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.1	medium_impact	3.57	high_impact	0.73	0.85	28.19	7.18	0.66	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13103	13103	G	C	MI.20878	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	767	256	G	A	gGa/gCa	7.07	1	0	probably_damaging	1	neutral	0.59	neutral	4.27	deleterious	-3.6	deleterious	-5.41	high_impact	5.23	0.48	damaging	0.09	damaging	3.06	22.40	deleterious	0.33	0.5	0.72	disease	0.72	disease	0.66	disease	0.66	disease	3	1	deleterious	0.3	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.32	medium_impact	3.57	high_impact	0.68	0.85	28.19	7.18	0.65	P	0.79	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13103	13103	G	T	MI.20879	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	767	256	G	V	gGa/gTa	7.07	1	0	probably_damaging	1	neutral	0.54	neutral	4.17	deleterious	-5	deleterious	-8.11	high_impact	5.23	0.39	damaging	0.05	damaging	3.69	23.30	deleterious	0.18	0.45	0.84	disease	0.9	disease	0.73	disease	0.68	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.27	medium_impact	3.57	high_impact	0.52	0.8	28.19	7.18	0.65	P	0.98	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6006	6006	C	G	MI.2088	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	103	35	L	V	Ctc/Gtc	-1.26	0	0	benign	0.03	neutral	0.08	neutral	2.55	neutral	-1.37	neutral	-0.6	neutral_impact	0.75	0.63	neutral	0.25	damaging	1.96	15.98	deleterious	0.39	0.55	0.37	neutral	0.15	neutral	0.2	neutral	0.28	neutral	4	0.92	neutral	0.53	deleterious	-6	neutral	0.16	neutral	0.66	medium_impact	-0.4	medium_impact	-0.41	medium_impact	0.77	0.9	9.16	26.4	0.47	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13105	13105	A	G	MI.20880	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	769	257	I	V	Atc/Gtc	-8.76	0	0.05	benign	0.01	neutral	0.52	neutral	4.65	neutral	1.31	neutral	0.02	neutral_impact	-0.72	0.94	neutral	0.96	neutral	-0.58	0.14	neutral	0.71	0.75	0.36	neutral	0.11	neutral	0.37	neutral	0.29	neutral	4	0.47	neutral	0.76	deleterious	-6	neutral	0.10	neutral	1.15	medium_impact	0.25	medium_impact	-1.86	low_impact	0.58	0.8	5.97	12.48	0.32	N	0.00	polymorphism	1	0.03	rs2853501	.	.	.	.	.	COSM6716789	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13105	13105	A	C	MI.20881	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	769	257	I	L	Atc/Ctc	-8.76	0	0.05	benign	0.08	neutral	0.68	neutral	4.82	neutral	-0.65	neutral	-1.8	medium_impact	2.56	0.68	neutral	0.41	neutral	1.93	15.76	deleterious	0.4	0.5	0.49	neutral	0.65	disease	0.56	disease	0.63	disease	3	0.23	neutral	0.8	deleterious	-3	neutral	0.23	neutral	0.26	medium_impact	0.41	medium_impact	1.14	medium_impact	0.77	0.85	5.97	12.48	0.25	N	0.63	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13105	13105	A	T	MI.20882	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	769	257	I	F	Atc/Ttc	-8.76	0	0.05	possibly_damaging	0.65	neutral	0.72	neutral	4.53	neutral	-1.42	deleterious	-3.6	high_impact	3.74	0.67	neutral	0.38	neutral	3.59	23.20	deleterious	0.39	0.5	0.66	disease	0.8	disease	0.64	disease	0.66	disease	3	0.57	neutral	0.54	deleterious	1	deleterious	0.70	deleterious	-1	low_impact	0.46	medium_impact	2.21	high_impact	0.80	0.85	5.97	12.48	0.27	N	0.89	polymorphism	0.78	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13106	13106	T	A	MI.20883	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	770	257	I	N	aTc/aAc	0.64	0.08	0	possibly_damaging	0.89	neutral	0.33	neutral	4.46	deleterious	-4.73	deleterious	-5.85	high_impact	4.08	0.67	neutral	0.38	neutral	4.56	24.40	deleterious	0.29	0.45	0.84	disease	0.82	disease	0.64	disease	0.68	disease	4	0.9	neutral	0.22	neutral	1	deleterious	0.79	deleterious	-1.61	low_impact	0.06	medium_impact	2.52	high_impact	0.72	0.85	5.97	12.48	0.42	N	0.92	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13106	13106	T	G	MI.20884	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	770	257	I	S	aTc/aGc	0.64	0.08	0	possibly_damaging	0.65	neutral	0.43	neutral	4.48	deleterious	-3.01	deleterious	-4.95	high_impact	3.54	0.71	neutral	0.45	neutral	3.95	23.60	deleterious	0.31	0.45	0.69	disease	0.84	disease	0.65	disease	0.7	disease	4	0.66	neutral	0.39	neutral	1	deleterious	0.62	deleterious	-1	low_impact	0.17	medium_impact	2.03	high_impact	0.64	0.8	5.97	12.48	0.38	N	0.87	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13106	13106	T	C	MI.20885	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	770	257	I	T	aTc/aCc	0.64	0.08	0	benign	0.25	neutral	0.44	neutral	4.52	neutral	-1.31	deleterious	-3.58	medium_impact	3.39	0.68	neutral	0.38	neutral	1.71	14.45	neutral	0.56	0.6	0.66	disease	0.69	disease	0.63	disease	0.65	disease	3	0.47	neutral	0.6	deleterious	-3	neutral	0.52	deleterious	-0.29	medium_impact	0.18	medium_impact	1.89	medium_impact	0.71	0.85	5.97	12.48	0.35	N	0.86	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13107	13107	C	A	MI.20886	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	771	257	I	M	atC/atA	7.3	0.95	0	possibly_damaging	0.8	neutral	0.25	neutral	4.53	neutral	-2.48	neutral	-2.24	medium_impact	3.4	0.74	neutral	0.49	neutral	3.65	23.20	deleterious	0.49	0.55	0.74	disease	0.61	disease	0.62	disease	0.65	disease	3	0.86	neutral	0.23	neutral	0	NA	0.67	deleterious	-1.32	low_impact	-0.03	medium_impact	1.9	medium_impact	0.85	0.9	5.97	12.48	0.55	P	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13107	13107	C	G	MI.20887	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	771	257	I	M	atC/atG	7.3	0.95	0	possibly_damaging	0.8	neutral	0.25	neutral	4.53	neutral	-2.48	neutral	-2.24	medium_impact	3.4	0.74	neutral	0.49	neutral	3.23	22.80	deleterious	0.49	0.55	0.74	disease	0.61	disease	0.62	disease	0.65	disease	3	0.86	neutral	0.23	neutral	0	NA	0.67	deleterious	-1.32	low_impact	-0.03	medium_impact	1.9	medium_impact	0.85	0.9	5.97	12.48	0.55	P	0.70	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13108	13108	T	G	MI.20888	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	772	258	F	V	Ttc/Gtc	-9.68	0	0	probably_damaging	0.91	neutral	0.64	neutral	4.62	neutral	-2.17	deleterious	-6.31	high_impact	3.77	0.45	damaging	0.45	neutral	4.05	23.70	deleterious	0.34	0.5	0.66	disease	0.91	disease	0.72	disease	0.73	disease	5	0.9	neutral	0.37	neutral	2	deleterious	0.81	deleterious	-1.7	low_impact	0.37	medium_impact	2.24	high_impact	0.75	0.85	6.8	8.13	0.4	N	0.95	polymorphism	0.61	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13108	13108	T	A	MI.20889	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	772	258	F	I	Ttc/Atc	-9.68	0	0	probably_damaging	0.94	neutral	0.64	neutral	4.65	neutral	-2.27	deleterious	-5.41	medium_impact	3.48	0.52	damaging	0.61	neutral	4.36	24.10	deleterious	0.24	0.45	0.48	neutral	0.89	disease	0.66	disease	0.71	disease	4	0.92	neutral	0.35	neutral	1	deleterious	0.78	deleterious	-1.88	low_impact	0.37	medium_impact	1.98	medium_impact	0.63	0.8	6.8	8.13	0.37	N	0.95	polymorphism	0.77	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6006	6006	C	A	MI.2089	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	103	35	L	I	Ctc/Atc	-1.26	0	0	benign	0.02	neutral	0.35	neutral	2.52	neutral	-1.67	neutral	-0.33	low_impact	1.4	0.7	neutral	0.95	neutral	2.45	19.17	deleterious	0.37	0.55	0.44	neutral	0.22	neutral	0.22	neutral	0.42	neutral	2	0.64	neutral	0.67	deleterious	-6	neutral	0.17	neutral	0.83	medium_impact	0.04	medium_impact	0.19	medium_impact	0.75	0.9	9.16	26.4	0.53	P	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13108	13108	T	C	MI.20890	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	772	258	F	L	Ttc/Ctc	-9.68	0	0	possibly_damaging	0.81	neutral	1	neutral	4.6	neutral	-1.74	deleterious	-5.41	high_impact	3.68	0.44	damaging	0.49	neutral	4.04	23.70	deleterious	0.45	0.55	0.43	neutral	0.83	disease	0.68	disease	0.69	disease	4	0.81	neutral	0.6	deleterious	1	deleterious	0.74	deleterious	-1.34	low_impact	1.89	high_impact	2.16	high_impact	0.79	0.85	6.8	8.13	0.45	N	0.92	polymorphism	0.75	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13109	13109	T	C	MI.20891	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	773	258	F	S	tTc/tCc	7.3	1	0	probably_damaging	0.96	neutral	0.58	neutral	4.57	deleterious	-3.42	deleterious	-7.21	high_impact	3.88	0.55	damaging	0.59	neutral	4.20	23.90	deleterious	0.26	0.45	0.84	disease	0.89	disease	0.7	disease	0.67	disease	3	0.95	neutral	0.31	neutral	2	deleterious	0.83	deleterious	-2.06	low_impact	0.31	medium_impact	2.34	high_impact	0.65	0.8	6.8	8.13	0.55	P	0.97	disease_causing	1	0.25	.	.	.	.	.	.	COSM6716790	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13109	13109	T	G	MI.20892	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	773	258	F	C	tTc/tGc	7.3	1	0	probably_damaging	0.99	neutral	0.15	neutral	4.51	deleterious	-5.01	deleterious	-7.21	high_impact	4.58	0.52	damaging	0.46	neutral	4.08	23.70	deleterious	0.28	0.45	0.92	disease	0.88	disease	0.73	disease	0.66	disease	3	0.99	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-2.64	low_impact	-0.18	medium_impact	2.98	high_impact	0.43	0.8	6.8	8.13	0.58	P	0.99	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13109	13109	T	A	MI.20893	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	773	258	F	Y	tTc/tAc	7.3	1	0	benign	0.17	neutral	0.79	neutral	4.85	neutral	1.27	deleterious	-2.7	neutral_impact	0.39	0.48	damaging	0.68	neutral	4.19	23.80	deleterious	0.25	0.45	0.43	neutral	0.78	disease	0.66	disease	0.39	neutral	2	0.11	neutral	0.81	deleterious	-6	neutral	0.73	deleterious	-0.09	medium_impact	0.55	medium_impact	-0.85	medium_impact	0.67	0.85	6.8	8.13	0.56	P	0.88	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13110	13110	C	A	MI.20894	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	774	258	F	L	ttC/ttA	5.69	1	0	possibly_damaging	0.81	neutral	1	neutral	4.6	neutral	-1.74	deleterious	-5.41	high_impact	3.68	0.44	damaging	0.49	neutral	4.65	24.50	deleterious	0.45	0.55	0.43	neutral	0.83	disease	0.68	disease	0.69	disease	4	0.81	neutral	0.6	deleterious	1	deleterious	0.74	deleterious	-1.34	low_impact	1.89	high_impact	2.16	high_impact	0.79	0.85	6.8	8.13	0.68	P	0.92	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13110	13110	C	G	MI.20895	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	774	258	F	L	ttC/ttG	5.69	1	0	possibly_damaging	0.81	neutral	1	neutral	4.6	neutral	-1.74	deleterious	-5.41	high_impact	3.68	0.44	damaging	0.49	neutral	4.35	24.10	deleterious	0.45	0.55	0.43	neutral	0.83	disease	0.68	disease	0.69	disease	4	0.81	neutral	0.6	deleterious	1	deleterious	0.74	deleterious	-1.34	low_impact	1.89	high_impact	2.16	high_impact	0.79	0.85	6.8	8.13	0.68	P	0.92	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13111	13111	T	A	MI.20896	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	775	259	L	M	Tta/Ata	-0.73	0	0	probably_damaging	1	neutral	0.33	neutral	4.3	neutral	-2.67	neutral	-1.73	medium_impact	2.77	0.56	damaging	0.13	damaging	3.49	23.10	deleterious	0.3	0.45	0.76	disease	0.57	disease	0.53	disease	0.35	neutral	3	1	deleterious	0.17	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.06	medium_impact	1.33	medium_impact	0.68	0.85	6.14	10.21	0.29	N	0.89	disease_causing	0.94	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13111	13111	T	G	MI.20897	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	775	259	L	V	Tta/Gta	-0.73	0	0	probably_damaging	1	neutral	0.78	neutral	4.37	neutral	-2.28	deleterious	-2.56	medium_impact	2.83	0.48	damaging	0.09	damaging	3.35	22.90	deleterious	0.27	0.45	0.72	disease	0.76	disease	0.63	disease	0.66	disease	3	1	deleterious	0.39	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.54	medium_impact	1.38	medium_impact	0.52	0.8	6.14	10.21	0.23	N	0.81	disease_causing	0.95	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13112	13112	T	C	MI.20898	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	776	259	L	S	tTa/tCa	-0.27	0	0	probably_damaging	1	neutral	0.59	neutral	4.28	deleterious	-4.1	deleterious	-5.13	high_impact	5.09	0.56	damaging	0.1	damaging	3.72	23.30	deleterious	0.17	0.45	0.79	disease	0.85	disease	0.63	disease	0.69	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.32	medium_impact	3.45	high_impact	0.62	0.8	6.14	10.21	0.6	P	0.97	polymorphism	0.94	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13112	13112	T	G	MI.20899	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	776	259	L	W	tTa/tGa	-0.27	0	0	probably_damaging	1	neutral	0.21	neutral	4.24	deleterious	-6.98	deleterious	-5.23	high_impact	5.09	0.6	damaging	0.09	damaging	3.75	23.30	deleterious	0.11	0.4	0.86	disease	0.83	disease	0.66	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.09	medium_impact	3.45	high_impact	0.46	0.8	6.14	10.21	0.61	P	0.98	polymorphism	0.9	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8624	8624	C	A	MI.209	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	98	33	T	N	aCc/aAc	-2.65	0	0	benign	0.28	neutral	0.41	neutral	4.28	neutral	-0.37	deleterious	-2.61	low_impact	0.84	0.9	neutral	0.84	neutral	0.55	7.82	deleterious	0.62	0.7	0.4	neutral	0.53	disease	0.47	neutral	0.47	neutral	1	0.51	neutral	0.57	deleterious	-6	neutral	0.34	neutral	-0.37	medium_impact	0.2	medium_impact	-0.38	medium_impact	0.66	0.9	19.47	19.69	0.32	N	0.39	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6007	6007	T	A	MI.2090	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	104	35	L	H	cTc/cAc	-0.11	0	0	possibly_damaging	0.88	deleterious	0	neutral	2.38	deleterious	-4.58	deleterious	-3.09	high_impact	3.69	0.59	damaging	0.11	damaging	3.99	23.60	deleterious	0.17	0.55	0.83	disease	0.65	disease	0.57	disease	0.72	disease	4	1	deleterious	0.06	neutral	5	deleterious	0.78	deleterious	-1.57	low_impact	-1.48	low_impact	2.31	high_impact	0.68	0.9	9.16	26.4	0.32	N	0.66	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13113	13113	A	C	MI.20900	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	777	259	L	F	ttA/ttC	5.69	0.86	0	probably_damaging	1	neutral	0.92	neutral	4.27	deleterious	-3.57	deleterious	-3.5	medium_impact	3.27	0.56	damaging	0.16	damaging	3.42	23.00	deleterious	0.27	0.45	0.84	disease	0.79	disease	0.63	disease	0.65	disease	3	1	deleterious	0.46	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.82	medium_impact	1.78	medium_impact	0.54	0.8	6.14	10.21	0.4	N	0.99	polymorphism	0.96	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13113	13113	A	T	MI.20901	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	777	259	L	F	ttA/ttT	5.69	0.86	0	probably_damaging	1	neutral	0.92	neutral	4.27	deleterious	-3.57	deleterious	-3.5	medium_impact	3.27	0.56	damaging	0.16	damaging	3.55	23.10	deleterious	0.27	0.45	0.84	disease	0.79	disease	0.63	disease	0.65	disease	3	1	deleterious	0.46	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.82	medium_impact	1.78	medium_impact	0.54	0.8	6.14	10.21	0.4	N	0.99	polymorphism	0.96	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13114	13114	C	T	MI.20902	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	778	260	L	F	Ctc/Ttc	-3.94	0	0	probably_damaging	0.94	neutral	0.64	neutral	3.98	deleterious	-3.04	deleterious	-3.4	high_impact	3.64	0.52	damaging	0.39	neutral	3.94	23.50	deleterious	0.33	0.5	0.67	disease	0.83	disease	0.66	disease	0.7	disease	4	0.94	neutral	0.35	neutral	2	deleterious	0.84	deleterious	-1.88	low_impact	0.37	medium_impact	2.12	high_impact	0.71	0.85	11.44	15.34	0.3	N	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13114	13114	C	A	MI.20903	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	778	260	L	I	Ctc/Atc	-3.94	0	0	benign	0.18	neutral	0.46	neutral	4.09	neutral	-2.04	neutral	-1.6	medium_impact	1.95	0.63	neutral	0.61	neutral	4.02	23.60	deleterious	0.31	0.45	0.53	disease	0.73	disease	0.56	disease	0.44	neutral	1	0.45	neutral	0.64	deleterious	-3	neutral	0.78	deleterious	-0.12	medium_impact	0.19	medium_impact	0.58	medium_impact	0.77	0.85	11.44	15.34	0.26	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13114	13114	C	G	MI.20904	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	778	260	L	V	Ctc/Gtc	-3.94	0	0	possibly_damaging	0.61	neutral	0.62	neutral	4.01	neutral	-2.71	neutral	-2.43	medium_impact	2.37	0.52	damaging	0.39	neutral	3.41	23.00	deleterious	0.32	0.5	0.5	neutral	0.69	disease	0.65	disease	0.45	neutral	1	0.55	neutral	0.51	deleterious	0	NA	0.77	deleterious	-0.93	medium_impact	0.35	medium_impact	0.96	medium_impact	0.79	0.85	11.44	15.34	0.26	N	0.61	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13115	13115	T	A	MI.20905	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	779	260	L	H	cTc/cAc	-0.04	0	0	probably_damaging	0.99	neutral	0.41	neutral	3.87	deleterious	-7.14	deleterious	-6.03	high_impact	4.84	0.52	damaging	0.32	neutral	4.22	23.90	deleterious	0.15	0.45	0.95	disease	0.9	disease	0.74	disease	0.73	disease	5	0.99	deleterious	0.21	neutral	2	deleterious	0.88	deleterious	-2.64	low_impact	0.15	medium_impact	3.22	high_impact	0.51	0.8	11.44	15.34	0.61	P	0.85	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13115	13115	T	G	MI.20906	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	779	260	L	R	cTc/cGc	-0.04	0	0	probably_damaging	0.98	neutral	0.3	neutral	3.87	deleterious	-6.53	deleterious	-5.16	high_impact	4.84	0.54	damaging	0.3	neutral	4.14	23.80	deleterious	0.14	0.4	0.93	disease	0.94	disease	0.75	disease	0.72	disease	4	0.98	deleterious	0.16	neutral	2	deleterious	0.93	deleterious	-2.35	low_impact	0.03	medium_impact	3.22	high_impact	0.42	0.8	11.44	15.34	0.64	P	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13115	13115	T	C	MI.20907	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	779	260	L	P	cTc/cCc	-0.04	0	0	probably_damaging	0.98	neutral	0.18	neutral	3.87	deleterious	-7.01	deleterious	-6.03	high_impact	4.84	0.49	damaging	0.34	neutral	3.93	23.50	deleterious	0.14	0.4	0.78	disease	0.9	disease	0.76	disease	0.75	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-2.35	low_impact	-0.13	medium_impact	3.22	high_impact	0.60	0.8	11.44	15.34	0.61	P	0.91	polymorphism	0.53	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13117	13117	A	C	MI.20908	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	781	261	I	L	Atc/Ctc	-10.14	0	0	probably_damaging	1	neutral	0.85	neutral	4.73	neutral	0.23	neutral	-1.79	low_impact	1.55	0.67	neutral	0.59	neutral	3.76	23.30	deleterious	0.37	0.5	0.35	neutral	0.7	disease	0.5	neutral	0.3	neutral	4	1	deleterious	0.43	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.65	medium_impact	0.21	medium_impact	0.74	0.85	3.81	8.06	0.26	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13117	13117	A	T	MI.20909	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	781	261	I	F	Atc/Ttc	-10.14	0	0	probably_damaging	1	neutral	0.75	neutral	4.58	neutral	-2.32	deleterious	-3.58	medium_impact	2.67	0.62	neutral	0.36	neutral	3.76	23.30	deleterious	0.31	0.45	0.76	disease	0.85	disease	0.67	disease	0.71	disease	4	1	deleterious	0.38	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.5	medium_impact	1.24	medium_impact	0.83	0.85	3.81	8.06	0.22	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6007	6007	T	C	MI.2091	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	104	35	L	P	cTc/cCc	-0.11	0	0	probably_damaging	0.94	deleterious	0	neutral	2.38	deleterious	-5.12	deleterious	-3.02	high_impact	4.04	0.53	damaging	0.11	damaging	3.75	23.30	deleterious	0.15	0.55	0.83	disease	0.84	disease	0.62	disease	0.78	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.87	deleterious	-1.88	low_impact	-1.48	low_impact	2.63	high_impact	0.67	0.9	9.16	26.4	0.31	N	0.80	polymorphism	0.91	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13117	13117	A	G	MI.20910	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	781	261	I	V	Atc/Gtc	-10.14	0	0	probably_damaging	1	neutral	0.63	neutral	4.7	neutral	-0.7	neutral	-0.64	low_impact	1.55	0.8	neutral	0.89	neutral	1.83	15.16	deleterious	0.56	0.6	0.56	disease	0.38	neutral	0.42	neutral	0.58	disease	2	1	deleterious	0.32	neutral	-2	neutral	0.66	deleterious	-3.6	low_impact	0.36	medium_impact	0.21	medium_impact	0.61	0.8	3.81	8.06	0.3	N	0.35	polymorphism	1	0.02	rs878966690	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13118	13118	T	C	MI.20911	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	782	261	I	T	aTc/aCc	1.56	0.81	0	probably_damaging	1	neutral	0.63	neutral	4.6	neutral	-2.45	deleterious	-4.19	medium_impact	3.27	0.65	neutral	0.61	neutral	3.41	23.00	deleterious	0.4	0.5	0.61	disease	0.77	disease	0.57	disease	0.56	disease	1	1	deleterious	0.32	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.36	medium_impact	1.78	medium_impact	0.69	0.85	3.81	8.06	0.28	N	0.95	polymorphism	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13118	13118	T	A	MI.20912	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	782	261	I	N	aTc/aAc	1.56	0.81	0	probably_damaging	1	neutral	0.52	neutral	4.57	deleterious	-4.04	deleterious	-6.13	high_impact	4.17	0.58	damaging	0.4	neutral	4.43	24.20	deleterious	0.22	0.45	0.9	disease	0.87	disease	0.66	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.25	medium_impact	2.61	high_impact	0.68	0.85	3.81	8.06	0.38	N	0.97	polymorphism	0.95	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13118	13118	T	G	MI.20913	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	782	261	I	S	aTc/aGc	1.56	0.81	0	probably_damaging	1	neutral	0.75	neutral	4.57	neutral	-2.97	deleterious	-5.23	high_impact	3.62	0.63	neutral	0.44	neutral	4.27	24.00	deleterious	0.27	0.45	0.83	disease	0.89	disease	0.62	disease	0.68	disease	4	1	deleterious	0.38	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.5	medium_impact	2.1	high_impact	0.63	0.8	3.81	8.06	0.3	N	0.96	polymorphism	0.94	0.10	.	.	.	.	.	.	COSM1472301	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13119	13119	C	G	MI.20914	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	783	261	I	M	atC/atG	7.3	0.98	0	probably_damaging	1	neutral	0.29	neutral	4.64	neutral	-2.05	deleterious	-2.56	medium_impact	2.4	0.65	neutral	0.47	neutral	3.35	22.90	deleterious	0.37	0.5	0.72	disease	0.71	disease	0.64	disease	0.65	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.02	medium_impact	0.99	medium_impact	0.80	0.85	3.81	8.06	0.52	P	0.72	disease_causing	0.71	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13119	13119	C	A	MI.20915	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	783	261	I	M	atC/atA	7.3	0.98	0	probably_damaging	1	neutral	0.29	neutral	4.64	neutral	-2.05	deleterious	-2.56	medium_impact	2.4	0.65	neutral	0.47	neutral	3.76	23.30	deleterious	0.37	0.5	0.72	disease	0.71	disease	0.64	disease	0.65	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.02	medium_impact	0.99	medium_impact	0.80	0.85	3.81	8.06	0.52	P	0.72	disease_causing	0.71	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13120	13120	C	A	MI.20916	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	784	262	R	S	Cgc/Agc	-2.57	0	0	probably_damaging	1	neutral	0.88	neutral	4.28	deleterious	-5.04	deleterious	-5.39	high_impact	4.44	0.6	damaging	0.07	damaging	4.51	24.30	deleterious	0.22	0.45	0.82	disease	0.88	disease	0.79	disease	0.71	disease	4	1	deleterious	0.44	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.71	medium_impact	2.85	high_impact	0.39	0.8	29.19	7.18	0.44	N	0.82	disease_causing	0.99	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13120	13120	C	G	MI.20917	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	784	262	R	G	Cgc/Ggc	-2.57	0	0	probably_damaging	1	neutral	0.61	neutral	4.19	deleterious	-6.47	deleterious	-6.3	high_impact	4.44	0.49	damaging	0.08	damaging	4.15	23.80	deleterious	0.24	0.45	0.94	disease	0.83	disease	0.8	disease	0.75	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.34	medium_impact	2.85	high_impact	0.28	0.8	29.19	7.18	0.47	N	0.97	disease_causing	0.99	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13120	13120	C	T	MI.20918	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	784	262	R	C	Cgc/Tgc	-2.57	0	0	probably_damaging	1	neutral	0.2	neutral	4.16	deleterious	-8.04	deleterious	-7.2	high_impact	4.79	0.48	damaging	0.05	damaging	4.94	25.00	deleterious	0.25	0.45	0.97	disease	0.89	disease	0.82	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.1	medium_impact	3.17	high_impact	0.62	0.8	29.19	7.18	0.52	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13121	13121	G	T	MI.20919	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	785	262	R	L	cGc/cTc	3.4	0.99	0	probably_damaging	1	neutral	0.83	neutral	4.2	deleterious	-4.56	deleterious	-6.3	high_impact	4.04	0.5	damaging	0.04	damaging	4.30	24.00	deleterious	0.22	0.45	0.84	disease	0.93	disease	0.78	disease	0.71	disease	4	1	deleterious	0.42	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.61	medium_impact	2.49	high_impact	0.37	0.8	29.19	7.18	0.54	P	1.00	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6007	6007	T	G	MI.2092	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	104	35	L	R	cTc/cGc	-0.11	0	0	possibly_damaging	0.84	deleterious	0	neutral	2.38	deleterious	-4.52	deleterious	-2.71	high_impact	3.69	0.55	damaging	0.09	damaging	4.05	23.70	deleterious	0.12	0.55	0.77	disease	0.79	disease	0.62	disease	0.76	disease	5	1	deleterious	0.08	neutral	5	deleterious	0.81	deleterious	-1.43	low_impact	-1.48	low_impact	2.31	high_impact	0.69	0.9	9.16	26.4	0.3	N	0.90	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13121	13121	G	A	MI.20920	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	785	262	R	H	cGc/cAc	3.4	0.99	0	probably_damaging	1	neutral	0.57	neutral	4.21	deleterious	-6.9	deleterious	-4.5	high_impact	4.24	0.54	damaging	0.04	damaging	4.38	24.10	deleterious	0.31	0.45	0.95	disease	0.87	disease	0.81	disease	0.71	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.3	medium_impact	2.67	high_impact	0.65	0.8	29.19	7.18	0.56	P	1.00	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13121	13121	G	C	MI.20921	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	785	262	R	P	cGc/cCc	3.4	0.99	0	probably_damaging	1	neutral	0.39	neutral	4.18	deleterious	-6.85	deleterious	-6.3	high_impact	5.13	0.54	damaging	0.06	damaging	4.24	23.90	deleterious	0.21	0.45	0.96	disease	0.9	disease	0.87	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.13	medium_impact	3.48	high_impact	0.25	0.8	29.19	7.18	0.64	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13123	13123	T	A	MI.20922	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	787	263	F	I	Ttc/Atc	-14.04	0	0	possibly_damaging	0.74	neutral	0.5	neutral	4.63	neutral	-1.29	deleterious	-5.41	low_impact	0.81	0.77	neutral	0.7	neutral	2.72	20.90	deleterious	0.23	0.45	0.54	disease	0.56	disease	0.33	neutral	0.37	neutral	3	0.72	neutral	0.38	neutral	-3	neutral	0.42	neutral	-1.18	low_impact	0.23	medium_impact	-0.46	medium_impact	0.75	0.85	9.78	7.14	0.28	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13123	13123	T	G	MI.20923	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	787	263	F	V	Ttc/Gtc	-14.04	0	0	possibly_damaging	0.74	neutral	0.53	neutral	4.7	neutral	-1.41	deleterious	-6.31	low_impact	1.24	0.82	neutral	0.68	neutral	2.45	19.11	deleterious	0.25	0.45	0.54	disease	0.67	disease	0.4	neutral	0.38	neutral	3	0.71	neutral	0.4	neutral	-3	neutral	0.42	neutral	-1.18	low_impact	0.26	medium_impact	-0.07	medium_impact	0.74	0.85	9.78	7.14	0.26	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13123	13123	T	C	MI.20924	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	787	263	F	L	Ttc/Ctc	-14.04	0	0	benign	0.08	neutral	0.76	neutral	4.88	neutral	-0.4	deleterious	-5.41	neutral_impact	-0.04	0.74	neutral	0.75	neutral	0.16	4.29	deleterious	0.48	0.55	0.4	neutral	0.27	neutral	0.28	neutral	0.46	neutral	1	0.14	neutral	0.84	deleterious	-6	neutral	0.14	neutral	0.26	medium_impact	0.51	medium_impact	-1.24	low_impact	0.82	0.85	9.78	7.14	0.32	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13124	13124	T	C	MI.20925	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	788	263	F	S	tTc/tCc	0.87	0.06	0	probably_damaging	0.96	neutral	0.43	neutral	4.53	neutral	-2.74	deleterious	-7.21	low_impact	1.86	0.84	neutral	0.68	neutral	4.08	23.70	deleterious	0.18	0.45	0.75	disease	0.6	disease	0.65	disease	0.56	disease	1	0.95	neutral	0.24	neutral	-2	neutral	0.69	deleterious	-2.06	low_impact	0.17	medium_impact	0.5	medium_impact	0.53	0.8	9.78	7.14	0.32	N	0.97	polymorphism	1	0.08	.	.	.	.	.	glioblastoma	COSM1155531	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13124	13124	T	A	MI.20926	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	788	263	F	Y	tTc/tAc	0.87	0.06	0	possibly_damaging	0.89	neutral	1	neutral	4.51	neutral	-2.6	deleterious	-2.7	low_impact	1.86	0.82	neutral	0.47	neutral	3.96	23.60	deleterious	0.24	0.45	0.82	disease	0.6	disease	0.63	disease	0.69	disease	4	0.89	neutral	0.56	deleterious	-3	neutral	0.66	deleterious	-1.61	low_impact	1.89	high_impact	0.5	medium_impact	0.73	0.85	9.78	7.14	0.2	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13124	13124	T	G	MI.20927	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	788	263	F	C	tTc/tGc	0.87	0.06	0	probably_damaging	0.98	neutral	0.19	neutral	4.51	deleterious	-3.46	deleterious	-7.21	low_impact	1.64	0.76	neutral	0.47	neutral	4.05	23.70	deleterious	0.23	0.45	0.87	disease	0.73	disease	0.66	disease	0.69	disease	4	0.99	deleterious	0.11	neutral	-2	neutral	0.77	deleterious	-2.35	low_impact	-0.12	medium_impact	0.3	medium_impact	0.42	0.8	9.78	7.14	0.31	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13125	13125	C	A	MI.20928	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	789	263	F	L	ttC/ttA	2.71	0.12	0	benign	0.08	neutral	0.76	neutral	4.88	neutral	-0.4	deleterious	-5.41	neutral_impact	-0.04	0.74	neutral	0.75	neutral	0.73	9.02	deleterious	0.48	0.55	0.4	neutral	0.27	neutral	0.28	neutral	0.46	neutral	1	0.14	neutral	0.84	deleterious	-6	neutral	0.14	neutral	0.26	medium_impact	0.51	medium_impact	-1.24	low_impact	0.82	0.85	9.78	7.14	0.3	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13125	13125	C	G	MI.20929	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	789	263	F	L	ttC/ttG	2.71	0.12	0	benign	0.08	neutral	0.76	neutral	4.88	neutral	-0.4	deleterious	-5.41	neutral_impact	-0.04	0.74	neutral	0.75	neutral	0.45	7.01	deleterious	0.48	0.55	0.4	neutral	0.27	neutral	0.28	neutral	0.46	neutral	1	0.14	neutral	0.84	deleterious	-6	neutral	0.14	neutral	0.26	medium_impact	0.51	medium_impact	-1.24	low_impact	0.82	0.85	9.78	7.14	0.31	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6009	6009	C	T	MI.2093	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	106	36	L	F	Ctt/Ttt	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-3.72	neutral	-2.06	medium_impact	2.67	0.51	damaging	0.06	damaging	3.75	23.30	deleterious	0.32	0.55	0.42	neutral	0.63	disease	0.44	neutral	0.51	disease	0	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	1.37	medium_impact	0.71	0.9	2.34	7.4	0.3	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13126	13126	C	G	MI.20930	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	790	264	H	D	Cac/Gac	-4.63	0	0	possibly_damaging	0.57	neutral	0.41	neutral	4.61	neutral	-1.55	deleterious	-6.08	medium_impact	2.52	0.72	neutral	0.39	neutral	2.23	17.69	deleterious	0.33	0.5	0.89	disease	0.84	disease	0.78	disease	0.74	disease	5	0.61	neutral	0.42	neutral	0	NA	0.63	deleterious	-0.86	medium_impact	0.15	medium_impact	1.1	medium_impact	0.64	0.8	2.32	8.94	0.28	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13126	13126	C	A	MI.20931	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	790	264	H	N	Cac/Aac	-4.63	0	0	possibly_damaging	0.44	neutral	0.46	neutral	4.73	neutral	1.53	deleterious	-4.74	low_impact	0.87	0.8	neutral	0.81	neutral	1.01	10.72	neutral	0.65	0.7	0.49	neutral	0.74	disease	0.51	disease	0.21	neutral	6	0.5	neutral	0.51	deleterious	-3	neutral	0.39	neutral	-0.65	medium_impact	0.19	medium_impact	-0.41	medium_impact	0.68	0.85	2.32	8.94	0.26	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13126	13126	C	T	MI.20932	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	790	264	H	Y	Cac/Tac	-4.63	0	0	benign	0.02	neutral	1	neutral	4.68	neutral	0.82	neutral	-0.64	neutral_impact	0.72	0.93	neutral	0.96	neutral	0.12	3.79	deleterious	0.71	0.75	0.5	neutral	0.71	disease	0.46	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.25	neutral	0.86	medium_impact	1.89	high_impact	-0.55	medium_impact	0.45	0.8	2.32	8.94	0.2	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13127	13127	A	C	MI.20933	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	791	264	H	P	cAc/cCc	-1.19	0	0	possibly_damaging	0.8	neutral	0.3	neutral	4.61	neutral	-1.5	deleterious	-6.57	high_impact	3.77	0.66	neutral	0.32	neutral	3.44	23.00	deleterious	0.32	0.5	0.88	disease	0.93	disease	0.8	disease	0.77	disease	5	0.84	neutral	0.25	neutral	1	deleterious	0.81	deleterious	-1.32	low_impact	0.03	medium_impact	2.24	high_impact	0.46	0.8	2.32	8.94	0.41	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13127	13127	A	T	MI.20934	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	791	264	H	L	cAc/cTc	-1.19	0	0	benign	0.36	neutral	0.81	neutral	4.79	neutral	2.1	deleterious	-6.2	medium_impact	2.27	0.78	neutral	0.46	neutral	2.52	19.59	deleterious	0.46	0.55	0.37	neutral	0.88	disease	0.7	disease	0.73	disease	5	0.24	neutral	0.73	deleterious	-3	neutral	0.34	neutral	-0.51	medium_impact	0.58	medium_impact	0.87	medium_impact	0.34	0.8	2.32	8.94	0.27	N	0.84	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13127	13127	A	G	MI.20935	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	791	264	H	R	cAc/cGc	-1.19	0	0	benign	0.03	neutral	0.51	neutral	4.63	neutral	-0.74	deleterious	-5.25	medium_impact	2.96	0.77	neutral	0.37	neutral	1.52	13.43	neutral	0.59	0.65	0.83	disease	0.85	disease	0.73	disease	0.73	disease	5	0.46	neutral	0.74	deleterious	-3	neutral	0.34	neutral	0.69	medium_impact	0.24	medium_impact	1.5	medium_impact	0.48	0.8	2.32	8.94	0.24	N	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13128	13128	C	G	MI.20936	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	792	264	H	Q	caC/caG	1.79	0	0	benign	0.04	neutral	0.48	neutral	4.62	neutral	-0.81	deleterious	-4.81	medium_impact	2.62	0.81	neutral	0.81	neutral	1.83	15.18	deleterious	0.67	0.7	0.71	disease	0.68	disease	0.49	neutral	0.28	neutral	4	0.48	neutral	0.72	deleterious	-3	neutral	0.48	deleterious	0.57	medium_impact	0.21	medium_impact	1.19	medium_impact	0.65	0.8	2.32	8.94	0.34	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13128	13128	C	A	MI.20937	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	792	264	H	Q	caC/caA	1.79	0	0	benign	0.04	neutral	0.48	neutral	4.62	neutral	-0.81	deleterious	-4.81	medium_impact	2.62	0.81	neutral	0.81	neutral	2.11	16.92	deleterious	0.67	0.7	0.71	disease	0.68	disease	0.49	neutral	0.28	neutral	4	0.48	neutral	0.72	deleterious	-3	neutral	0.48	deleterious	0.57	medium_impact	0.21	medium_impact	1.19	medium_impact	0.65	0.8	2.32	8.94	0.33	N	0.63	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13129	13129	C	A	MI.20938	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	793	265	P	T	Ccc/Acc	-0.73	0	0	probably_damaging	0.97	neutral	0.68	neutral	4.58	deleterious	-3.2	deleterious	-6.72	high_impact	3.59	0.57	damaging	0.4	neutral	3.67	23.20	deleterious	0.4	0.5	0.81	disease	0.83	disease	0.59	disease	0.67	disease	3	0.96	neutral	0.36	neutral	2	deleterious	0.76	deleterious	-2.18	low_impact	0.41	medium_impact	2.08	high_impact	0.75	0.85	8.62	7.2	0.26	N	0.91	disease_causing	0.79	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13129	13129	C	G	MI.20939	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	793	265	P	A	Ccc/Gcc	-0.73	0	0	probably_damaging	0.94	neutral	0.9	neutral	4.6	neutral	-2.84	deleterious	-6.72	medium_impact	2.79	0.55	damaging	0.47	neutral	2.72	20.90	deleterious	0.41	0.5	0.77	disease	0.72	disease	0.7	disease	0.69	disease	4	0.93	neutral	0.48	deleterious	1	deleterious	0.66	deleterious	-1.88	low_impact	0.76	medium_impact	1.35	medium_impact	0.79	0.85	8.62	7.2	0.21	N	0.73	disease_causing	0.71	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6009	6009	C	G	MI.2094	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	106	36	L	V	Ctt/Gtt	-20	0	0	probably_damaging	0.99	neutral	0.09	neutral	2.54	neutral	-2.52	neutral	-1.16	medium_impact	2.5	0.57	damaging	0.09	damaging	1.44	13.01	neutral	0.3	0.55	0.35	neutral	0.5	neutral	0.31	neutral	0.46	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.71	deleterious	-2.64	low_impact	-0.37	medium_impact	1.21	medium_impact	0.72	0.9	2.34	7.4	0.3	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13129	13129	C	T	MI.20940	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	793	265	P	S	Ccc/Tcc	-0.73	0	0	probably_damaging	0.96	neutral	0.84	neutral	4.61	deleterious	-3.47	deleterious	-6.62	medium_impact	3.1	0.6	damaging	0.47	neutral	3.56	23.10	deleterious	0.5	0.6	0.77	disease	0.81	disease	0.58	disease	0.42	neutral	2	0.95	neutral	0.44	neutral	1	deleterious	0.71	deleterious	-2.06	low_impact	0.63	medium_impact	1.63	medium_impact	0.39	0.8	8.62	7.2	0.24	N	0.78	disease_causing	0.8	0.11	.	.	.	.	.	.	COSM1138246	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13130	13130	C	G	MI.20941	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	794	265	P	R	cCc/cGc	4.31	0.98	0	probably_damaging	0.96	neutral	0.61	neutral	4.57	deleterious	-4.98	deleterious	-7.54	high_impact	4.45	0.55	damaging	0.38	neutral	3.47	23.00	deleterious	0.3	0.45	0.92	disease	0.91	disease	0.81	disease	0.73	disease	5	0.95	neutral	0.33	neutral	2	deleterious	0.81	deleterious	-2.06	low_impact	0.34	medium_impact	2.86	high_impact	0.62	0.8	8.62	7.2	0.59	P	0.64	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13130	13130	C	T	MI.20942	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	794	265	P	L	cCc/cTc	4.31	0.98	0	probably_damaging	0.97	neutral	0.73	neutral	4.66	neutral	-2.4	deleterious	-8.49	medium_impact	2.88	0.52	damaging	0.43	neutral	4.29	24.00	deleterious	0.53	0.6	0.45	neutral	0.89	disease	0.66	disease	0.71	disease	4	0.96	neutral	0.38	neutral	1	deleterious	0.73	deleterious	-2.18	low_impact	0.47	medium_impact	1.43	medium_impact	0.78	0.85	8.62	7.2	0.45	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13130	13130	C	A	MI.20943	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	794	265	P	H	cCc/cAc	4.31	0.98	0	benign	0.4	neutral	0.41	neutral	4.54	deleterious	-5.89	deleterious	-7.27	high_impact	3.59	0.55	damaging	0.55	neutral	2.09	16.76	deleterious	0.38	0.5	0.94	disease	0.88	disease	0.72	disease	0.68	disease	4	0.53	neutral	0.51	deleterious	-2	neutral	0.36	neutral	-0.58	medium_impact	0.15	medium_impact	2.08	high_impact	0.66	0.8	8.62	7.2	0.48	N	0.72	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13132	13132	C	A	MI.20944	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	796	266	L	M	Cta/Ata	-20	0	0.01	possibly_damaging	0.49	neutral	0.28	neutral	4.28	deleterious	-3.18	neutral	-1.37	low_impact	1.5	0.84	neutral	0.89	neutral	2.33	18.39	deleterious	0.37	0.5	0.77	disease	0.22	neutral	0.22	neutral	0.53	disease	1	0.69	neutral	0.4	neutral	-3	neutral	0.73	deleterious	-0.73	medium_impact	0.01	medium_impact	0.17	medium_impact	0.72	0.85	14.76	12.06	0.43	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13132	13132	C	G	MI.20945	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	796	266	L	V	Cta/Gta	-20	0	0.01	possibly_damaging	0.81	neutral	0.58	neutral	4.36	neutral	-2.14	neutral	-2.13	low_impact	1.42	0.8	neutral	0.62	neutral	3.37	22.90	deleterious	0.41	0.5	0.68	disease	0.58	disease	0.41	neutral	0.43	neutral	2	0.78	neutral	0.39	neutral	-3	neutral	0.76	deleterious	-1.34	low_impact	0.31	medium_impact	0.09	medium_impact	0.57	0.8	14.76	12.06	0.21	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13133	13133	T	G	MI.20946	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	797	266	L	R	cTa/cGa	-7.16	0	0	probably_damaging	0.97	neutral	0.5	neutral	4.25	deleterious	-5.94	deleterious	-5.05	high_impact	4.29	0.62	neutral	0.28	neutral	4.15	23.80	deleterious	0.31	0.45	0.95	disease	0.89	disease	0.74	disease	0.77	disease	5	0.97	neutral	0.27	neutral	2	deleterious	0.91	deleterious	-2.18	low_impact	0.23	medium_impact	2.72	high_impact	0.47	0.8	14.76	12.06	0.37	N	0.96	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13133	13133	T	A	MI.20947	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	797	266	L	Q	cTa/cAa	-7.16	0	0	probably_damaging	0.98	neutral	0.48	neutral	4.25	deleterious	-5.61	deleterious	-4.99	high_impact	3.94	0.71	neutral	0.36	neutral	4.04	23.70	deleterious	0.32	0.5	0.95	disease	0.81	disease	0.61	disease	0.77	disease	5	0.98	neutral	0.25	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	0.21	medium_impact	2.4	high_impact	0.48	0.8	14.76	12.06	0.3	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13133	13133	T	C	MI.20948	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	797	266	L	P	cTa/cCa	-7.16	0	0	benign	0.23	neutral	0.32	neutral	4.28	deleterious	-6.21	deleterious	-5.85	medium_impact	3.48	0.65	neutral	0.27	damaging	3.88	23.50	deleterious	0.26	0.45	0.96	disease	0.88	disease	0.75	disease	0.77	disease	5	0.61	neutral	0.55	deleterious	-3	neutral	0.91	deleterious	-0.25	medium_impact	0.05	medium_impact	1.98	medium_impact	0.49	0.8	14.76	12.06	0.29	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13135	13135	G	A	MI.20949	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	799	267	A	T	Gca/Aca	-5.78	0	0.03	benign	0.01	neutral	0.49	neutral	4.62	neutral	-1.47	neutral	0.53	neutral_impact	0.42	0.9	neutral	0.97	neutral	0.97	10.47	neutral	0.64	0.7	0.54	disease	0.21	neutral	0.26	neutral	0.42	neutral	2	0.5	neutral	0.74	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.22	medium_impact	-0.82	medium_impact	0.74	0.85	15.26	13.11	0.44	N	0.04	polymorphism	1	0.00	rs200044200	.	.	.	.	.	.	.	.	G13135A	possible HCM susceptibility	+	-	Reported	1	N	P	N,P	neutral
chrM	6009	6009	C	A	MI.2095	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	106	36	L	I	Ctt/Att	-20	0	0	probably_damaging	1	neutral	0.27	neutral	2.6	neutral	-1.73	neutral	-0.58	neutral_impact	0.48	0.58	damaging	0.23	damaging	0.65	8.48	deleterious	0.33	0.55	0.21	neutral	0.15	neutral	0.2	neutral	0.26	neutral	5	1	deleterious	0.14	neutral	-2	neutral	0.67	deleterious	-3.58	low_impact	-0.05	medium_impact	-0.66	medium_impact	0.76	0.9	2.34	7.4	0.44	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13135	13135	G	T	MI.20950	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	799	267	A	S	Gca/Tca	-5.78	0	0.03	benign	0.27	neutral	0.51	neutral	4.62	neutral	-2.08	neutral	-0.4	neutral_impact	-0.66	0.74	neutral	0.69	neutral	2.04	16.45	deleterious	0.6	0.65	0.48	neutral	0.29	neutral	0.39	neutral	0.41	neutral	2	0.39	neutral	0.62	deleterious	-6	neutral	0.40	neutral	-0.34	medium_impact	0.24	medium_impact	-1.81	low_impact	0.88	0.9	15.26	13.11	0.31	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13135	13135	G	C	MI.20951	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	799	267	A	P	Gca/Cca	-5.78	0	0.03	possibly_damaging	0.73	neutral	0.26	neutral	4.56	neutral	-1.1	neutral	-1.47	neutral_impact	0.17	0.64	neutral	0.4	neutral	3.71	23.30	deleterious	0.24	0.45	0.55	disease	0.74	disease	0.59	disease	0.67	disease	3	0.81	neutral	0.27	neutral	-3	neutral	0.75	deleterious	-1.16	low_impact	-0.02	medium_impact	-1.05	low_impact	0.85	0.9	15.26	13.11	0.28	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13136	13136	C	A	MI.20952	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	800	267	A	E	gCa/gAa	-1.19	0	0	possibly_damaging	0.46	neutral	0.41	neutral	4.56	deleterious	-3.91	neutral	-1.45	low_impact	0.98	0.7	neutral	0.62	neutral	4.14	23.80	deleterious	0.2	0.45	0.82	disease	0.62	disease	0.58	disease	0.67	disease	3	0.55	neutral	0.48	deleterious	-3	neutral	0.64	deleterious	-0.68	medium_impact	0.15	medium_impact	-0.31	medium_impact	0.76	0.85	15.26	13.11	0.27	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13136	13136	C	G	MI.20953	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	800	267	A	G	gCa/gGa	-1.19	0	0	benign	0.34	neutral	0.39	neutral	4.55	neutral	-1.18	neutral	-2.29	low_impact	0.98	0.73	neutral	0.66	neutral	2.33	18.37	deleterious	0.4	0.5	0.64	disease	0.3	neutral	0.38	neutral	0.59	disease	2	0.54	neutral	0.53	deleterious	-6	neutral	0.52	deleterious	-0.47	medium_impact	0.13	medium_impact	-0.31	medium_impact	0.93	0.95	15.26	13.11	0.33	N	0.43	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13136	13136	C	T	MI.20954	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	800	267	A	V	gCa/gTa	-1.19	0	0	benign	0.12	neutral	0.54	neutral	4.63	neutral	-0.64	neutral	1.55	neutral_impact	-0.47	0.84	neutral	0.84	neutral	2.74	21.10	deleterious	0.63	0.7	0.47	neutral	0.34	neutral	0.28	neutral	0.47	neutral	1	0.37	neutral	0.71	deleterious	-6	neutral	0.37	neutral	0.08	medium_impact	0.27	medium_impact	-1.63	low_impact	0.81	0.85	15.26	13.11	0.26	N	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13138	13138	G	A	MI.20955	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	802	268	E	K	Gaa/Aaa	-1.42	0	0	probably_damaging	1	neutral	0.61	neutral	4.58	neutral	-0.65	neutral	-2.26	low_impact	1.36	0.78	neutral	0.19	damaging	4.42	24.20	deleterious	0.44	0.55	0.71	disease	0.77	disease	0.6	disease	0.56	disease	1	1	deleterious	0.31	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.34	medium_impact	0.04	medium_impact	0.52	0.8	21.89	16.2	0.16	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13138	13138	G	C	MI.20956	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	802	268	E	Q	Gaa/Caa	-1.42	0	0	probably_damaging	1	neutral	0.48	neutral	4.57	neutral	-0.84	neutral	-1.1	neutral_impact	0.54	0.82	neutral	0.78	neutral	2.10	16.87	deleterious	0.67	0.7	0.7	disease	0.45	neutral	0.28	neutral	0.62	disease	2	1	deleterious	0.24	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.21	medium_impact	-0.71	medium_impact	0.73	0.85	21.89	16.2	0.32	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13139	13139	A	G	MI.20957	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	803	268	E	G	gAa/gGa	-0.27	0	0	probably_damaging	1	neutral	0.46	neutral	4.51	neutral	-1.96	deleterious	-4.75	low_impact	1.03	0.83	neutral	0.19	damaging	4.04	23.70	deleterious	0.6	0.65	0.7	disease	0.64	disease	0.65	disease	0.59	disease	2	1	deleterious	0.23	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.19	medium_impact	-0.26	medium_impact	0.48	0.8	21.89	16.2	0.25	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13139	13139	A	T	MI.20958	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	803	268	E	V	gAa/gTa	-0.27	0	0	probably_damaging	1	neutral	0.6	neutral	4.5	neutral	-2.44	deleterious	-4.71	low_impact	1.84	0.81	neutral	0.13	damaging	3.99	23.60	deleterious	0.34	0.5	0.82	disease	0.75	disease	0.64	disease	0.67	disease	3	1	deleterious	0.3	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.33	medium_impact	0.48	medium_impact	0.68	0.85	21.89	16.2	0.18	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13139	13139	A	C	MI.20959	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	803	268	E	A	gAa/gCa	-0.27	0	0	probably_damaging	1	neutral	0.76	neutral	4.54	neutral	-1.27	deleterious	-3.82	neutral_impact	0.55	0.79	neutral	0.37	neutral	3.50	23.10	deleterious	0.51	0.6	0.59	disease	0.47	neutral	0.53	disease	0.6	disease	2	1	deleterious	0.38	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.51	medium_impact	-0.7	medium_impact	0.55	0.8	21.89	16.2	0.19	N	0.59	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6010	6010	T	A	MI.2096	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	107	36	L	H	cTt/cAt	-0.34	0	0	probably_damaging	1	deleterious	0	neutral	2.41	deleterious	-5.17	deleterious	-3.84	high_impact	4.52	0.59	damaging	0.05	damaging	3.95	23.60	deleterious	0.12	0.55	0.84	disease	0.78	disease	0.6	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.07	high_impact	0.63	0.9	2.34	7.4	0.37	N	0.83	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13140	13140	A	C	MI.20960	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	804	268	E	D	gaA/gaC	1.33	0	0	probably_damaging	1	neutral	0.42	neutral	4.54	neutral	-1.27	neutral	-2.02	low_impact	1.8	0.77	neutral	0.17	damaging	3.64	23.20	deleterious	0.58	0.65	0.77	disease	0.58	disease	0.45	neutral	0.54	disease	1	1	deleterious	0.21	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.16	medium_impact	0.44	medium_impact	0.77	0.85	21.89	16.2	0.23	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13140	13140	A	T	MI.20961	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	804	268	E	D	gaA/gaT	1.33	0	0	probably_damaging	1	neutral	0.42	neutral	4.54	neutral	-1.27	neutral	-2.02	low_impact	1.8	0.77	neutral	0.17	damaging	3.77	23.40	deleterious	0.58	0.65	0.77	disease	0.58	disease	0.45	neutral	0.54	disease	1	1	deleterious	0.21	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.16	medium_impact	0.44	medium_impact	0.77	0.85	21.89	16.2	0.24	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13141	13141	A	G	MI.20962	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	805	269	N	D	Aat/Gat	-1.65	0	0	benign	0.06	neutral	0.4	neutral	4.6	neutral	-0.74	deleterious	-2.99	low_impact	1.55	0.83	neutral	0.87	neutral	0.94	10.32	neutral	0.85	0.9	0.53	disease	0.51	disease	0.42	neutral	0.37	neutral	3	0.56	neutral	0.67	deleterious	-6	neutral	0.52	deleterious	0.39	medium_impact	0.14	medium_impact	0.21	medium_impact	0.35	0.8	9.95	16.38	0.34	N	0.25	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13141	13141	A	T	MI.20963	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	805	269	N	Y	Aat/Tat	-1.65	0	0	probably_damaging	0.95	neutral	1	neutral	4.58	neutral	-1.05	deleterious	-4.78	low_impact	1.05	0.85	neutral	0.65	neutral	3.47	23.00	deleterious	0.52	0.6	0.36	neutral	0.66	disease	0.67	disease	0.48	neutral	0	0.95	neutral	0.53	deleterious	-2	neutral	0.70	deleterious	-1.96	low_impact	1.89	high_impact	-0.24	medium_impact	0.28	0.8	9.95	16.38	0.19	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13141	13141	A	C	MI.20964	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	805	269	N	H	Aat/Cat	-1.65	0	0	probably_damaging	0.97	neutral	0.59	neutral	4.55	neutral	-2.11	neutral	-2.44	low_impact	1	0.82	neutral	0.96	neutral	1.75	14.70	neutral	0.68	0.7	0.67	disease	0.56	disease	0.43	neutral	0.38	neutral	2	0.96	neutral	0.31	neutral	-2	neutral	0.73	deleterious	-2.18	low_impact	0.32	medium_impact	-0.29	medium_impact	0.31	0.8	9.95	16.38	0.24	N	0.21	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13142	13142	A	C	MI.20965	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	806	269	N	T	aAt/aCt	-0.27	0	0	benign	0.1	neutral	0.59	neutral	4.59	neutral	-0.83	deleterious	-3.25	low_impact	0.9	0.89	neutral	0.97	neutral	0.54	7.71	deleterious	0.73	0.75	0.53	disease	0.42	neutral	0.29	neutral	0.44	neutral	1	0.32	neutral	0.75	deleterious	-6	neutral	0.47	deleterious	0.16	medium_impact	0.32	medium_impact	-0.38	medium_impact	0.31	0.8	9.95	16.38	0.32	N	0.17	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13142	13142	A	T	MI.20966	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	806	269	N	I	aAt/aTt	-0.27	0	0	possibly_damaging	0.78	neutral	0.5	neutral	4.57	neutral	-1.41	deleterious	-5.63	low_impact	1.87	0.8	neutral	0.53	neutral	3.61	23.20	deleterious	0.53	0.6	0.85	disease	0.76	disease	0.61	disease	0.71	disease	4	0.76	neutral	0.36	neutral	-3	neutral	0.75	deleterious	-1.27	low_impact	0.23	medium_impact	0.51	medium_impact	0.24	0.8	9.95	16.38	0.22	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13142	13142	A	G	MI.20967	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	806	269	N	S	aAt/aGt	-0.27	0	0	benign	0.1	neutral	0.65	neutral	4.72	neutral	0.75	deleterious	-2.77	neutral_impact	0.68	0.86	neutral	0.94	neutral	-0.04	2.24	deleterious	0.75	0.8	0.48	neutral	0.46	neutral	0.35	neutral	0.42	neutral	2	0.25	neutral	0.78	deleterious	-6	neutral	0.21	neutral	0.16	medium_impact	0.38	medium_impact	-0.58	medium_impact	0.10	0.8	9.95	16.38	0.28	N	0.34	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13143	13143	T	G	MI.20968	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	807	269	N	K	aaT/aaG	-0.04	0	0.01	possibly_damaging	0.56	neutral	0.59	neutral	4.62	neutral	-0.4	deleterious	-3.73	low_impact	1.47	0.81	neutral	0.62	neutral	2.50	19.45	deleterious	0.81	0.85	0.6	disease	0.65	disease	0.47	neutral	0.38	neutral	2	0.5	neutral	0.52	deleterious	-3	neutral	0.60	deleterious	-0.85	medium_impact	0.32	medium_impact	0.14	medium_impact	0.37	0.8	9.95	16.38	0.21	N	0.74	polymorphism	1	0.06	rs386829174	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13143	13143	T	A	MI.20969	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	807	269	N	K	aaT/aaA	-0.04	0	0.01	possibly_damaging	0.56	neutral	0.59	neutral	4.62	neutral	-0.4	deleterious	-3.73	low_impact	1.47	0.81	neutral	0.62	neutral	2.88	21.80	deleterious	0.81	0.85	0.6	disease	0.65	disease	0.47	neutral	0.38	neutral	2	0.5	neutral	0.52	deleterious	-3	neutral	0.60	deleterious	-0.85	medium_impact	0.32	medium_impact	0.14	medium_impact	0.37	0.8	9.95	16.38	0.22	N	0.74	polymorphism	1	0.06	rs386829174	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6010	6010	T	G	MI.2097	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	107	36	L	R	cTt/cGt	-0.34	0	0	probably_damaging	1	deleterious	0	neutral	2.41	deleterious	-4.1	deleterious	-3.4	high_impact	4.52	0.55	damaging	0.06	damaging	4.00	23.60	deleterious	0.1	0.55	0.79	disease	0.86	disease	0.64	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.07	high_impact	0.68	0.9	2.34	7.4	0.39	N	0.90	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13144	13144	A	C	MI.20970	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	808	270	S	R	Agc/Cgc	-7.38	0	0	benign	0.26	neutral	0.52	neutral	4.51	deleterious	-3.05	neutral	-1.07	high_impact	3.61	0.59	damaging	0.47	neutral	1.92	15.69	deleterious	0.38	0.5	0.71	disease	0.8	disease	0.72	disease	0.73	disease	5	0.38	neutral	0.63	deleterious	-2	neutral	0.51	deleterious	-0.32	medium_impact	0.25	medium_impact	2.1	high_impact	0.74	0.85	5.64	7.11	0.29	N	0.24	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13144	13144	A	G	MI.20971	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	808	270	S	G	Agc/Ggc	-7.38	0	0	benign	0.18	neutral	0.39	neutral	4.53	neutral	-1.95	neutral	-1.03	medium_impact	2.86	0.67	neutral	0.59	neutral	1.53	13.47	neutral	0.52	0.6	0.33	neutral	0.49	neutral	0.55	disease	0.56	disease	1	0.53	neutral	0.61	deleterious	-3	neutral	0.20	neutral	-0.12	medium_impact	0.13	medium_impact	1.41	medium_impact	0.76	0.85	5.64	7.11	0.33	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13144	13144	A	T	MI.20972	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	808	270	S	C	Agc/Tgc	-7.38	0	0	possibly_damaging	0.89	neutral	0.06	neutral	4.47	deleterious	-5.63	deleterious	-3.65	medium_impact	2.92	0.66	neutral	0.43	neutral	3.21	22.70	deleterious	0.46	0.55	0.95	disease	0.64	disease	0.44	neutral	0.75	disease	5	0.98	neutral	0.09	neutral	0	NA	0.76	deleterious	-1.61	low_impact	-0.43	medium_impact	1.46	medium_impact	0.63	0.8	5.64	7.11	0.33	N	0.70	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13145	13145	G	C	MI.20973	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	809	270	S	T	aGc/aCc	4.31	0.98	0.01	benign	0.18	neutral	0.58	neutral	4.54	neutral	-1.28	neutral	-0.99	low_impact	0.98	0.7	neutral	0.67	neutral	1.56	13.62	neutral	0.49	0.55	0.55	disease	0.38	neutral	0.41	neutral	0.61	disease	2	0.31	neutral	0.7	deleterious	-6	neutral	0.33	neutral	-0.12	medium_impact	0.31	medium_impact	-0.31	medium_impact	0.66	0.8	5.64	7.11	0.48	N	0.21	polymorphism	1	0.02	rs386829175	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13145	13145	G	A	MI.20974	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	809	270	S	N	aGc/aAc	4.31	0.98	0.01	benign	0.01	neutral	0.51	neutral	4.6	neutral	-2.49	neutral	4.16	neutral_impact	0.44	0.85	neutral	0.96	neutral	-1.05	0.01	neutral	0.83	0.85	0.4	neutral	0.08	neutral	0.18	neutral	0.29	neutral	4	0.48	neutral	0.75	deleterious	-6	neutral	0.13	neutral	1.15	medium_impact	0.24	medium_impact	-0.8	medium_impact	0.67	0.85	5.64	7.11	0.55	P	0.00	polymorphism	1	0.01	rs386829175	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13145	13145	G	T	MI.20975	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	809	270	S	I	aGc/aTc	4.31	0.98	0.01	possibly_damaging	0.62	neutral	0.2	neutral	4.54	deleterious	-3.16	deleterious	-3.69	low_impact	1.86	0.68	neutral	0.58	neutral	3.80	23.40	deleterious	0.49	0.55	0.79	disease	0.72	disease	0.56	disease	0.68	disease	4	0.81	neutral	0.29	neutral	-3	neutral	0.61	deleterious	-0.95	medium_impact	-0.1	medium_impact	0.5	medium_impact	0.77	0.85	5.64	7.11	0.49	N	0.57	polymorphism	1	0.06	rs386829175	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13147	13147	C	A	MI.20976	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	811	271	P	T	Cca/Aca	-2.11	0	0	benign	0.01	neutral	0.61	neutral	4.61	neutral	-2.24	neutral	-0.32	low_impact	1.45	0.88	neutral	0.96	neutral	0.50	7.45	deleterious	0.54	0.6	0.8	disease	0.2	neutral	0.22	neutral	0.53	disease	1	0.37	neutral	0.8	deleterious	-6	neutral	0.26	neutral	1.15	medium_impact	0.34	medium_impact	0.12	medium_impact	0.70	0.85	30.35	19.69	0.33	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13147	13147	C	T	MI.20977	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	811	271	P	S	Cca/Tca	-2.11	0	0	benign	0.01	neutral	0.77	neutral	4.62	neutral	-1.82	neutral	0.31	low_impact	1.49	0.86	neutral	0.95	neutral	0.39	6.52	deleterious	0.58	0.65	0.56	disease	0.22	neutral	0.21	neutral	0.54	disease	1	0.21	neutral	0.88	deleterious	-6	neutral	0.13	neutral	1.15	medium_impact	0.52	medium_impact	0.16	medium_impact	0.25	0.8	30.35	19.69	0.34	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	COSM6716780	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13147	13147	C	G	MI.20978	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	811	271	P	A	Cca/Gca	-2.11	0	0	benign	0.05	neutral	0.8	neutral	4.62	neutral	-1.3	neutral	-0.48	medium_impact	2.06	0.82	neutral	0.82	neutral	-0.10	1.75	neutral	0.52	0.6	0.62	disease	0.16	neutral	0.39	neutral	0.42	neutral	2	0.12	neutral	0.88	deleterious	-3	neutral	0.18	neutral	0.47	medium_impact	0.57	medium_impact	0.68	medium_impact	0.83	0.85	30.35	19.69	0.29	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13148	13148	C	G	MI.20979	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	812	271	P	R	cCa/cGa	-1.88	0	0	benign	0.26	neutral	0.54	neutral	4.58	deleterious	-3	neutral	0.91	medium_impact	3.19	0.81	neutral	0.6	neutral	0.76	9.23	deleterious	0.45	0.55	0.69	disease	0.5	neutral	0.51	disease	0.52	disease	0	0.35	neutral	0.64	deleterious	-3	neutral	0.38	neutral	-0.32	medium_impact	0.27	medium_impact	1.71	medium_impact	0.61	0.8	30.35	19.69	0.27	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6010	6010	T	C	MI.2098	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	107	36	L	P	cTt/cCt	-0.34	0	0	probably_damaging	1	deleterious	0	neutral	2.41	deleterious	-5.28	deleterious	-3.85	high_impact	3.97	0.5	damaging	0.07	damaging	3.69	23.30	deleterious	0.12	0.55	0.84	disease	0.86	disease	0.66	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.57	high_impact	0.68	0.9	2.34	7.4	0.29	N	0.83	disease_causing	0.99	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13148	13148	C	T	MI.20980	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	812	271	P	L	cCa/cTa	-1.88	0	0	benign	0	neutral	0.43	neutral	4.6	deleterious	-3.31	neutral	-1.09	low_impact	1.7	0.83	neutral	0.81	neutral	1.45	13.04	neutral	0.55	0.6	0.69	disease	0.38	neutral	0.4	neutral	0.63	disease	3	0.56	neutral	0.72	deleterious	-6	neutral	0.33	neutral	2.1	high_impact	0.17	medium_impact	0.35	medium_impact	0.66	0.8	30.35	19.69	0.36	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13148	13148	C	A	MI.20981	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	812	271	P	Q	cCa/cAa	-1.88	0	0	benign	0.02	neutral	0.61	neutral	4.59	neutral	-2.31	neutral	1.28	low_impact	0.83	0.82	neutral	0.94	neutral	-0.60	0.12	neutral	0.36	0.5	0.71	disease	0.15	neutral	0.21	neutral	0.38	neutral	3	0.36	neutral	0.8	deleterious	-6	neutral	0.14	neutral	0.86	medium_impact	0.34	medium_impact	-0.45	medium_impact	0.61	0.8	30.35	19.69	0.31	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13150	13150	C	A	MI.20982	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	814	272	L	M	Cta/Ata	-4.4	0	0	benign	0.32	neutral	0.35	neutral	4.51	neutral	-2.43	neutral	-0.44	low_impact	0.96	0.82	neutral	0.96	neutral	2.18	17.41	deleterious	0.39	0.5	0.75	disease	0.2	neutral	0.33	neutral	0.53	disease	1	0.58	neutral	0.52	deleterious	-6	neutral	0.66	deleterious	-0.44	medium_impact	0.08	medium_impact	-0.33	medium_impact	0.72	0.85	20.07	13.68	0.38	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13150	13150	C	G	MI.20983	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	814	272	L	V	Cta/Gta	-4.4	0	0	possibly_damaging	0.44	neutral	0.53	neutral	4.59	neutral	-1.09	neutral	-0.34	low_impact	0.99	0.87	neutral	0.88	neutral	0.16	4.23	deleterious	0.42	0.55	0.5	neutral	0.26	neutral	0.35	neutral	0.37	neutral	3	0.44	neutral	0.55	deleterious	-3	neutral	0.35	neutral	-0.65	medium_impact	0.26	medium_impact	-0.3	medium_impact	0.48	0.8	20.07	13.68	0.31	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13151	13151	T	C	MI.20984	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	815	272	L	P	cTa/cCa	-0.73	0	0	benign	0.08	neutral	0.32	neutral	4.51	deleterious	-3.69	neutral	-1.85	low_impact	1.64	0.88	neutral	0.83	neutral	0.66	8.58	deleterious	0.24	0.45	0.39	neutral	0.77	disease	0.57	disease	0.54	disease	1	0.64	neutral	0.62	deleterious	-6	neutral	0.22	neutral	0.26	medium_impact	0.05	medium_impact	0.3	medium_impact	0.52	0.8	20.07	13.68	0.3	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13151	13151	T	G	MI.20985	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	815	272	L	R	cTa/cGa	-0.73	0	0	possibly_damaging	0.83	neutral	0.51	neutral	4.54	neutral	-2.26	neutral	-1.84	medium_impact	3	0.69	neutral	0.45	neutral	2.40	18.80	deleterious	0.36	0.5	0.8	disease	0.76	disease	0.64	disease	0.73	disease	5	0.81	neutral	0.34	neutral	0	NA	0.62	deleterious	-1.4	low_impact	0.24	medium_impact	1.54	medium_impact	0.61	0.8	20.07	13.68	0.27	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13151	13151	T	A	MI.20986	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	815	272	L	Q	cTa/cAa	-0.73	0	0	possibly_damaging	0.87	neutral	0.65	neutral	4.55	neutral	-1.91	neutral	-1.71	low_impact	1.72	0.77	neutral	0.71	neutral	2.55	19.79	deleterious	0.31	0.45	0.6	disease	0.57	disease	0.49	neutral	0.46	neutral	1	0.85	neutral	0.39	neutral	-3	neutral	0.61	deleterious	-1.53	low_impact	0.38	medium_impact	0.37	medium_impact	0.58	0.8	20.07	13.68	0.23	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13153	13153	A	C	MI.20987	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	817	273	I	L	Atc/Ctc	-8.53	0	0	benign	0.03	neutral	1	neutral	4.65	neutral	0.52	neutral	-1.17	neutral_impact	0.19	0.84	neutral	0.82	neutral	0.47	7.20	deleterious	0.35	0.5	0.4	neutral	0.39	neutral	0.54	disease	0.49	neutral	0	0.03	neutral	0.99	deleterious	-6	neutral	0.20	neutral	0.69	medium_impact	1.89	high_impact	-1.03	low_impact	0.55	0.8	6.14	9.22	0.26	N	0.68	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13153	13153	A	G	MI.20988	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	817	273	I	V	Atc/Gtc	-8.53	0	0	benign	0.03	neutral	0.45	neutral	4.61	neutral	0.55	neutral	-0.4	neutral_impact	0.26	0.87	neutral	0.96	neutral	-0.90	0.03	neutral	0.62	0.65	0.51	disease	0.18	neutral	0.38	neutral	0.26	neutral	5	0.52	neutral	0.71	deleterious	-6	neutral	0.12	neutral	0.69	medium_impact	0.18	medium_impact	-0.97	medium_impact	0.39	0.8	6.14	9.22	0.36	N	0.55	polymorphism	1	0.01	rs878957731	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13153	13153	A	T	MI.20989	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	817	273	I	F	Atc/Ttc	-8.53	0	0	possibly_damaging	0.72	neutral	0.47	neutral	4.51	neutral	-0.36	deleterious	-2.58	neutral_impact	0.24	0.78	neutral	0.5	neutral	2.49	19.42	deleterious	0.45	0.55	0.73	disease	0.57	disease	0.61	disease	0.58	disease	2	0.7	neutral	0.38	neutral	-3	neutral	0.66	deleterious	-1.14	low_impact	0.2	medium_impact	-0.98	medium_impact	0.63	0.8	6.14	9.22	0.22	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6012	6012	A	G	MI.2099	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	109	37	I	V	Att/Gtt	-4.5	0	0	probably_damaging	0.95	neutral	0.11	neutral	2.72	neutral	-0.99	neutral	-0.56	medium_impact	2.95	0.57	damaging	0.62	neutral	2.86	21.70	deleterious	0.42	0.55	0.44	neutral	0.47	neutral	0.45	neutral	0.44	neutral	1	0.98	deleterious	0.08	neutral	1	deleterious	0.63	deleterious	-1.96	low_impact	-0.31	medium_impact	1.63	medium_impact	0.65	0.9	1.75	6.65	0.49	N	0.23	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13154	13154	T	A	MI.20990	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	818	273	I	N	aTc/aAc	-0.27	0	0	possibly_damaging	0.83	neutral	0.51	neutral	4.46	deleterious	-3.56	deleterious	-4.89	low_impact	1.55	0.73	neutral	0.41	neutral	4.45	24.20	deleterious	0.36	0.5	0.66	disease	0.74	disease	0.6	disease	0.71	disease	4	0.81	neutral	0.34	neutral	-3	neutral	0.71	deleterious	-1.4	low_impact	0.24	medium_impact	0.21	medium_impact	0.59	0.8	6.14	9.22	0.26	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13154	13154	T	C	MI.20991	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	818	273	I	T	aTc/aCc	-0.27	0	0	benign	0.04	neutral	0.87	neutral	4.5	neutral	-1	deleterious	-2.99	neutral_impact	0.33	0.83	neutral	0.8	neutral	0.63	8.35	deleterious	0.49	0.55	0.39	neutral	0.41	neutral	0.41	neutral	0.46	neutral	1	0.05	neutral	0.92	deleterious	-6	neutral	0.36	neutral	0.57	medium_impact	0.69	medium_impact	-0.9	medium_impact	0.58	0.8	6.14	9.22	0.24	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13154	13154	T	G	MI.20992	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	818	273	I	S	aTc/aGc	-0.27	0	0	possibly_damaging	0.48	neutral	0.7	neutral	4.51	neutral	-1.58	deleterious	-3.78	neutral_impact	0.53	0.77	neutral	0.76	neutral	2.51	19.53	deleterious	0.4	0.5	0.37	neutral	0.61	disease	0.43	neutral	0.46	neutral	1	0.38	neutral	0.61	deleterious	-3	neutral	0.39	neutral	-0.71	medium_impact	0.44	medium_impact	-0.72	medium_impact	0.51	0.8	6.14	9.22	0.22	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13155	13155	C	A	MI.20993	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	819	273	I	M	atC/atA	-0.73	0	0	possibly_damaging	0.83	neutral	0.49	neutral	4.55	neutral	-1.17	neutral	-1.62	neutral_impact	0.46	0.84	neutral	0.95	neutral	2.53	19.65	deleterious	0.49	0.55	0.36	neutral	0.35	neutral	0.38	neutral	0.45	neutral	1	0.82	neutral	0.33	neutral	-3	neutral	0.59	deleterious	-1.4	low_impact	0.22	medium_impact	-0.78	medium_impact	0.68	0.85	6.14	9.22	0.32	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13155	13155	C	G	MI.20994	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	819	273	I	M	atC/atG	-0.73	0	0	possibly_damaging	0.83	neutral	0.49	neutral	4.55	neutral	-1.17	neutral	-1.62	neutral_impact	0.46	0.84	neutral	0.95	neutral	2.09	16.80	deleterious	0.49	0.55	0.36	neutral	0.35	neutral	0.38	neutral	0.45	neutral	1	0.82	neutral	0.33	neutral	-3	neutral	0.59	deleterious	-1.4	low_impact	0.22	medium_impact	-0.78	medium_impact	0.68	0.85	6.14	9.22	0.32	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13156	13156	C	A	MI.20995	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	820	274	Q	K	Caa/Aaa	-6.24	0	0	probably_damaging	1	neutral	0.91	neutral	4.63	neutral	-1.13	neutral	-2.13	neutral_impact	0.8	0.79	neutral	0.6	neutral	2.74	21.00	deleterious	0.55	0.6	0.54	disease	0.64	disease	0.68	disease	0.67	disease	3	1	deleterious	0.46	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.79	medium_impact	-0.47	medium_impact	0.75	0.85	20.73	16.44	0.18	N	0.62	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13156	13156	C	G	MI.20996	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	820	274	Q	E	Caa/Gaa	-6.24	0	0	probably_damaging	1	neutral	1	neutral	4.6	neutral	-0.96	neutral	-1.98	low_impact	1.45	0.67	neutral	0.47	neutral	3.08	22.50	deleterious	0.6	0.65	0.59	disease	0.6	disease	0.68	disease	0.73	disease	5	1	deleterious	0.5	deleterious	-2	neutral	0.76	deleterious	-3.6	low_impact	1.89	high_impact	0.12	medium_impact	0.75	0.85	20.73	16.44	0.2	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13157	13157	A	G	MI.20997	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	821	274	Q	R	cAa/cGa	-0.27	0	0	probably_damaging	1	neutral	0.51	neutral	4.61	neutral	-0.85	neutral	-2.17	low_impact	1.07	0.74	neutral	0.49	neutral	2.30	18.16	deleterious	0.7	0.75	0.7	disease	0.67	disease	0.7	disease	0.74	disease	5	1	deleterious	0.26	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.24	medium_impact	-0.23	medium_impact	0.68	0.85	20.73	16.44	0.24	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13157	13157	A	C	MI.20998	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	821	274	Q	P	cAa/cCa	-0.27	0	0	probably_damaging	1	neutral	0.28	neutral	4.54	neutral	-2.64	deleterious	-3.64	low_impact	1.24	0.57	damaging	0.39	neutral	3.33	22.90	deleterious	0.3	0.45	0.49	neutral	0.85	disease	0.7	disease	0.79	disease	6	1	deleterious	0.14	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.01	medium_impact	-0.07	medium_impact	0.70	0.85	20.73	16.44	0.29	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13157	13157	A	T	MI.20999	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	821	274	Q	L	cAa/cTa	-0.27	0	0	probably_damaging	1	neutral	0.46	neutral	4.66	neutral	0.2	neutral	-2.12	neutral_impact	-1.6	0.75	neutral	0.89	neutral	1.10	11.20	neutral	0.39	0.5	0.56	disease	0.19	neutral	0.32	neutral	0.44	neutral	1	1	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.19	medium_impact	-2.66	low_impact	0.38	0.8	20.73	16.44	0.3	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8535	8535	A	C	MI.21	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	9	3	E	D	gaA/gaC	4.06	1	0	probably_damaging	0.95	neutral	0.24	neutral	4.64	neutral	-0.82	neutral	-1.77	low_impact	1.61	0.84	neutral	0.46	neutral	3.66	23.20	deleterious	0.62	0.7	0.61	disease	0.13	neutral	0.18	neutral	0.41	neutral	2	0.96	neutral	0.15	neutral	-2	neutral	0.64	deleterious	-1.97	low_impact	0.01	medium_impact	0.28	medium_impact	0.92	0.95	15.93	14.48	0.56	P	0.87	polymorphism	0.9	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8624	8624	C	T	MI.210	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	98	33	T	I	aCc/aTc	-2.65	0	0	benign	0.17	neutral	0.3	neutral	4.24	neutral	-1.66	deleterious	-4.14	low_impact	1.88	0.85	neutral	0.64	neutral	1.99	16.17	deleterious	0.5	0.65	0.42	neutral	0.62	disease	0.59	disease	0.66	disease	3	0.65	neutral	0.57	deleterious	-6	neutral	0.28	neutral	-0.1	medium_impact	0.08	medium_impact	0.51	medium_impact	0.40	0.9	19.47	19.69	0.36	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6012	6012	A	T	MI.2100	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	109	37	I	F	Att/Ttt	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.6	neutral	-1.56	neutral	-2.36	high_impact	4.1	0.58	damaging	0.38	neutral	3.62	23.20	deleterious	0.23	0.55	0.75	disease	0.8	disease	0.49	neutral	0.62	disease	2	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.69	high_impact	0.79	0.9	1.75	6.65	0.36	N	0.85	disease_causing	0.53	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13158	13158	A	T	MI.21000	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	822	274	Q	H	caA/caT	0.87	0	0	probably_damaging	1	neutral	0.15	neutral	4.58	neutral	-2.07	deleterious	-3.12	low_impact	1.53	0.74	neutral	0.55	neutral	3.52	23.10	deleterious	0.66	0.7	0.57	disease	0.46	neutral	0.64	disease	0.65	disease	3	1	deleterious	0.08	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	-0.18	medium_impact	0.2	medium_impact	0.76	0.85	20.73	16.44	0.36	N	0.64	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13158	13158	A	C	MI.21001	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	822	274	Q	H	caA/caC	0.87	0	0	probably_damaging	1	neutral	0.15	neutral	4.58	neutral	-2.07	deleterious	-3.12	low_impact	1.53	0.74	neutral	0.55	neutral	3.30	22.90	deleterious	0.66	0.7	0.57	disease	0.46	neutral	0.64	disease	0.65	disease	3	1	deleterious	0.08	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	-0.18	medium_impact	0.2	medium_impact	0.76	0.85	20.73	16.44	0.36	N	0.64	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13159	13159	A	C	MI.21002	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	823	275	T	P	Act/Cct	-1.19	0	0	possibly_damaging	0.9	neutral	0.2	neutral	4.61	neutral	-0.64	deleterious	-4.78	low_impact	1.64	0.67	neutral	0.41	neutral	3.36	22.90	deleterious	0.25	0.45	0.87	disease	0.85	disease	0.77	disease	0.74	disease	5	0.94	neutral	0.15	neutral	-3	neutral	0.84	deleterious	-1.65	low_impact	-0.1	medium_impact	0.3	medium_impact	0.76	0.85	12.77	12.77	0.32	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13159	13159	A	T	MI.21003	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	823	275	T	S	Act/Tct	-1.19	0	0	benign	0.09	neutral	0.58	neutral	4.67	neutral	0.35	deleterious	-2.58	neutral_impact	0.34	0.85	neutral	0.96	neutral	1.84	15.24	deleterious	0.57	0.65	0.72	disease	0.3	neutral	0.43	neutral	0.6	disease	2	0.33	neutral	0.75	deleterious	-6	neutral	0.73	deleterious	0.21	medium_impact	0.31	medium_impact	-0.89	medium_impact	0.63	0.8	12.77	12.77	0.3	N	0.19	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13159	13159	A	G	MI.21004	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	823	275	T	A	Act/Gct	-1.19	0	0	possibly_damaging	0.54	neutral	0.56	neutral	4.63	neutral	-0.31	deleterious	-3.79	medium_impact	2.1	0.73	neutral	0.62	neutral	3.32	22.90	deleterious	0.64	0.7	0.61	disease	0.48	neutral	0.65	disease	0.59	disease	2	0.5	neutral	0.51	deleterious	0	NA	0.73	deleterious	-0.81	medium_impact	0.29	medium_impact	0.72	medium_impact	0.51	0.8	12.77	12.77	0.27	N	0.77	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13160	13160	C	T	MI.21005	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	824	275	T	I	aCt/aTt	2.25	0	0	probably_damaging	0.93	neutral	0.47	neutral	4.65	neutral	0.15	deleterious	-4.94	low_impact	1.6	0.71	neutral	0.54	neutral	3.87	23.50	deleterious	0.55	0.6	0.36	neutral	0.71	disease	0.64	disease	0.51	disease	0	0.93	neutral	0.27	neutral	-2	neutral	0.72	deleterious	-1.81	low_impact	0.2	medium_impact	0.26	medium_impact	0.69	0.85	12.77	12.77	0.29	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13160	13160	C	G	MI.21006	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	824	275	T	S	aCt/aGt	2.25	0	0	benign	0.09	neutral	0.58	neutral	4.67	neutral	0.35	deleterious	-2.58	neutral_impact	0.34	0.85	neutral	0.96	neutral	2.20	17.49	deleterious	0.57	0.65	0.72	disease	0.3	neutral	0.43	neutral	0.6	disease	2	0.33	neutral	0.75	deleterious	-6	neutral	0.73	deleterious	0.21	medium_impact	0.31	medium_impact	-0.89	medium_impact	0.63	0.8	12.77	12.77	0.31	N	0.19	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13160	13160	C	A	MI.21007	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	824	275	T	N	aCt/aAt	2.25	0	0	benign	0.05	neutral	0.41	neutral	4.7	neutral	0.73	deleterious	-3.52	low_impact	1.36	0.79	neutral	0.65	neutral	3.68	23.30	deleterious	0.66	0.7	0.9	disease	0.73	disease	0.59	disease	0.68	disease	4	0.55	neutral	0.68	deleterious	-6	neutral	0.79	deleterious	0.47	medium_impact	0.15	medium_impact	0.04	medium_impact	0.77	0.85	12.77	12.77	0.25	N	0.38	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13162	13162	C	A	MI.21008	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	826	276	L	M	Cta/Ata	-14.5	0	0	possibly_damaging	0.61	neutral	0.29	neutral	4.45	neutral	-2.6	neutral	-0.42	low_impact	0.94	0.86	neutral	0.95	neutral	2.28	18.02	deleterious	0.4	0.5	0.61	disease	0.17	neutral	0.31	neutral	0.41	neutral	2	0.73	neutral	0.34	neutral	-3	neutral	0.67	deleterious	-0.93	medium_impact	0.02	medium_impact	-0.34	medium_impact	0.70	0.85	18.08	15.31	0.45	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13162	13162	C	G	MI.21009	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	826	276	L	V	Cta/Gta	-14.5	0	0	possibly_damaging	0.73	neutral	0.53	neutral	4.61	neutral	-0.43	neutral	-1.33	neutral_impact	0.49	0.88	neutral	0.97	neutral	1.11	11.27	neutral	0.36	0.5	0.61	disease	0.14	neutral	0.28	neutral	0.32	neutral	4	0.69	neutral	0.4	neutral	-3	neutral	0.67	deleterious	-1.16	low_impact	0.26	medium_impact	-0.76	medium_impact	0.66	0.8	18.08	15.31	0.33	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6012	6012	A	C	MI.2101	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	109	37	I	L	Att/Ctt	-4.5	0	0	probably_damaging	0.98	deleterious	0	neutral	2.74	neutral	-0.92	neutral	-1.16	high_impact	3.75	0.61	neutral	0.45	neutral	3.65	23.20	deleterious	0.28	0.55	0.25	neutral	0.68	disease	0.41	neutral	0.51	disease	0	1	deleterious	0.01	neutral	6	deleterious	0.62	deleterious	-2.35	low_impact	-1.48	low_impact	2.36	high_impact	0.68	0.9	1.75	6.65	0.5	N	0.61	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13163	13163	T	C	MI.21010	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	827	276	L	P	cTa/cCa	-8.53	0	0	probably_damaging	0.98	neutral	0.22	neutral	4.45	deleterious	-4	deleterious	-4.36	medium_impact	2.56	0.57	damaging	0.4	neutral	3.78	23.40	deleterious	0.08	0.35	0.96	disease	0.76	disease	0.67	disease	0.78	disease	6	0.98	deleterious	0.12	neutral	1	deleterious	0.86	deleterious	-2.35	low_impact	-0.07	medium_impact	1.14	medium_impact	0.61	0.8	18.08	15.31	0.27	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13163	13163	T	A	MI.21011	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	827	276	L	Q	cTa/cAa	-8.53	0	0	probably_damaging	0.98	neutral	0.35	neutral	4.42	deleterious	-4.85	deleterious	-3.51	high_impact	3.54	0.74	neutral	0.58	neutral	3.91	23.50	deleterious	0.11	0.4	0.95	disease	0.52	disease	0.47	neutral	0.77	disease	5	0.98	neutral	0.19	neutral	2	deleterious	0.80	deleterious	-2.35	low_impact	0.08	medium_impact	2.03	high_impact	0.69	0.85	18.08	15.31	0.36	N	0.66	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13163	13163	T	G	MI.21012	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	827	276	L	R	cTa/cGa	-8.53	0	0	probably_damaging	0.97	neutral	0.34	neutral	4.43	deleterious	-5.04	deleterious	-3.74	high_impact	3.54	0.67	neutral	0.47	neutral	4.01	23.60	deleterious	0.08	0.35	0.94	disease	0.67	disease	0.62	disease	0.77	disease	5	0.97	neutral	0.19	neutral	2	deleterious	0.85	deleterious	-2.18	low_impact	0.07	medium_impact	2.03	high_impact	0.58	0.8	18.08	15.31	0.31	N	0.64	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13165	13165	A	C	MI.21013	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	829	277	T	P	Aca/Cca	-8.53	0	0	probably_damaging	0.93	neutral	0.23	neutral	4.56	neutral	-1.82	deleterious	-3.17	medium_impact	2.19	0.6	neutral	0.35	neutral	3.40	23.00	deleterious	0.19	0.45	0.5	neutral	0.82	disease	0.68	disease	0.77	disease	5	0.95	neutral	0.15	neutral	1	deleterious	0.75	deleterious	-1.81	low_impact	-0.06	medium_impact	0.8	medium_impact	0.74	0.85	10.95	13.27	0.25	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13165	13165	A	G	MI.21014	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	829	277	T	A	Aca/Gca	-8.53	0	0	benign	0.05	neutral	0.56	neutral	4.61	neutral	0.45	neutral	-1.7	neutral_impact	0.32	0.82	neutral	0.94	neutral	0.23	4.96	deleterious	0.53	0.6	0.46	neutral	0.28	neutral	0.47	neutral	0.44	neutral	1	0.38	neutral	0.76	deleterious	-6	neutral	0.17	neutral	0.47	medium_impact	0.29	medium_impact	-0.91	medium_impact	0.52	0.8	10.95	13.27	0.3	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13165	13165	A	T	MI.21015	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	829	277	T	S	Aca/Tca	-8.53	0	0	possibly_damaging	0.64	neutral	0.59	neutral	4.59	neutral	-0.99	neutral	-1.49	low_impact	1.16	0.78	neutral	0.84	neutral	1.66	14.16	neutral	0.46	0.55	0.7	disease	0.39	neutral	0.46	neutral	0.63	disease	3	0.59	neutral	0.48	deleterious	-3	neutral	0.52	deleterious	-0.98	medium_impact	0.32	medium_impact	-0.14	medium_impact	0.80	0.85	10.95	13.27	0.26	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13166	13166	C	T	MI.21016	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	830	277	T	M	aCa/aTa	0.18	0	0	probably_damaging	0.95	neutral	0.28	neutral	4.63	neutral	0.33	neutral	-1.26	neutral_impact	0.62	0.83	neutral	0.95	neutral	2.47	19.27	deleterious	0.42	0.5	0.77	disease	0.5	neutral	0.37	neutral	0.51	disease	0	0.96	neutral	0.17	neutral	-2	neutral	0.73	deleterious	-1.96	low_impact	0.01	medium_impact	-0.64	medium_impact	0.80	0.85	10.95	13.27	0.33	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13166	13166	C	A	MI.21017	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	830	277	T	K	aCa/aAa	0.18	0	0	possibly_damaging	0.82	neutral	0.3	neutral	4.57	neutral	-2.44	deleterious	-2.92	medium_impact	2.19	0.74	neutral	0.42	neutral	4.19	23.80	deleterious	0.2	0.45	0.85	disease	0.7	disease	0.67	disease	0.77	disease	5	0.85	neutral	0.24	neutral	0	NA	0.72	deleterious	-1.37	low_impact	0.03	medium_impact	0.8	medium_impact	0.73	0.85	10.95	13.27	0.27	N	0.89	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13168	13168	C	A	MI.21018	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	832	278	L	M	Cta/Ata	-6.7	0	0	probably_damaging	1	neutral	0.27	neutral	4.43	neutral	-2.16	neutral	-1.3	medium_impact	2.54	0.71	neutral	0.28	damaging	3.72	23.30	deleterious	0.4	0.5	NA	NA	0.52	disease	0.57	disease	0.43	neutral	1	1	deleterious	0.14	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.01	medium_impact	1.12	medium_impact	0.62	0.8	12.94	6.99	0.33	N	0.89	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13168	13168	C	G	MI.21019	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	832	278	L	V	Cta/Gta	-6.7	0	0	probably_damaging	1	neutral	0.57	neutral	4.55	neutral	-1.28	deleterious	-2.5	medium_impact	2.58	0.66	neutral	0.09	damaging	3.44	23.00	deleterious	0.39	0.5	NA	NA	0.51	disease	0.66	disease	0.54	disease	1	1	deleterious	0.29	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.3	medium_impact	1.15	medium_impact	0.58	0.8	12.94	6.99	0.2	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6013	6013	T	C	MI.2102	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	110	37	I	T	aTt/aCt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-2.47	deleterious	-2.93	high_impact	4.65	0.63	neutral	0.4	neutral	3.11	22.50	deleterious	0.29	0.55	0.82	disease	0.77	disease	0.47	neutral	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.57	0.9	1.75	6.65	0.57	P	0.76	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13169	13169	T	G	MI.21020	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	833	278	L	R	cTa/cGa	0.41	0.05	0	probably_damaging	1	neutral	0.29	neutral	4.37	deleterious	-4.9	deleterious	-5.11	high_impact	4.54	0.62	neutral	0.08	damaging	4.15	23.80	deleterious	0.17	0.45	NA	NA	0.87	disease	0.77	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.02	medium_impact	2.94	high_impact	0.55	0.8	12.94	6.99	0.55	N	1.00	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13169	13169	T	A	MI.21021	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	833	278	L	Q	cTa/cAa	0.41	0.05	0	probably_damaging	1	neutral	0.28	neutral	4.37	deleterious	-4.56	deleterious	-5.01	high_impact	3.85	0.68	neutral	0.1	damaging	4.25	23.90	deleterious	0.21	0.45	NA	NA	0.81	disease	0.67	disease	0.67	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.01	medium_impact	2.31	high_impact	0.61	0.8	12.94	6.99	0.36	N	0.98	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13169	13169	T	C	MI.21022	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	833	278	L	P	cTa/cCa	0.41	0.05	0	probably_damaging	1	neutral	0.17	neutral	4.37	deleterious	-4.9	deleterious	-6.01	high_impact	3.56	0.63	neutral	0.09	damaging	3.99	23.60	deleterious	0.21	0.45	NA	NA	0.83	disease	0.77	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.15	medium_impact	2.05	high_impact	0.64	0.8	12.94	6.99	0.37	N	0.99	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13171	13171	T	A	MI.21023	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	835	279	C	S	Tgc/Agc	-3.94	0	0	benign	0.05	neutral	0.62	neutral	4.67	neutral	0.36	deleterious	-8.13	low_impact	1.18	0.78	neutral	0.87	neutral	2.40	18.83	deleterious	0.39	0.5	0.69	disease	0.81	disease	0.64	disease	0.56	disease	1	0.32	neutral	0.79	deleterious	-6	neutral	0.79	deleterious	0.47	medium_impact	0.35	medium_impact	-0.13	medium_impact	0.55	0.8	9.62	13.35	0.24	N	0.45	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13171	13171	T	G	MI.21024	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	835	279	C	G	Tgc/Ggc	-3.94	0	0	possibly_damaging	0.54	neutral	0.38	neutral	4.66	neutral	1.35	deleterious	-10.04	low_impact	1.45	0.7	neutral	0.45	neutral	3.28	22.80	deleterious	0.32	0.5	0.71	disease	0.89	disease	0.7	disease	0.75	disease	5	0.62	neutral	0.42	neutral	-3	neutral	0.79	deleterious	-0.81	medium_impact	0.12	medium_impact	0.12	medium_impact	0.46	0.8	9.62	13.35	0.33	N	0.79	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13171	13171	T	C	MI.21025	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	835	279	C	R	Tgc/Cgc	-3.94	0	0	probably_damaging	0.91	neutral	0.29	neutral	4.64	neutral	-1.65	deleterious	-10.1	medium_impact	2.92	0.65	neutral	0.3	neutral	3.47	23.00	deleterious	0.37	0.5	0.86	disease	0.94	disease	0.78	disease	0.86	disease	7	0.93	neutral	0.19	neutral	1	deleterious	0.89	deleterious	-1.7	low_impact	0.02	medium_impact	1.46	medium_impact	0.39	0.8	9.62	13.35	0.37	N	0.89	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13172	13172	G	C	MI.21026	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	836	279	C	S	tGc/tCc	5.69	1	0	benign	0.05	neutral	0.62	neutral	4.67	neutral	0.36	deleterious	-8.13	low_impact	1.18	0.78	neutral	0.87	neutral	2.06	16.62	deleterious	0.39	0.5	0.69	disease	0.81	disease	0.64	disease	0.56	disease	1	0.32	neutral	0.79	deleterious	-6	neutral	0.79	deleterious	0.47	medium_impact	0.35	medium_impact	-0.13	medium_impact	0.55	0.8	9.62	13.35	0.43	N	0.45	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13172	13172	G	T	MI.21027	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	836	279	C	F	tGc/tTc	5.69	1	0	probably_damaging	0.97	neutral	0.7	neutral	4.68	neutral	1.55	deleterious	-9.32	neutral_impact	0.36	0.68	neutral	0.37	neutral	3.87	23.50	deleterious	0.33	0.5	0.6	disease	0.91	disease	0.7	disease	0.58	disease	1	0.96	neutral	0.37	neutral	-2	neutral	0.81	deleterious	-2.18	low_impact	0.44	medium_impact	-0.87	medium_impact	0.57	0.8	9.62	13.35	0.38	N	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13172	13172	G	A	MI.21028	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	836	279	C	Y	tGc/tAc	5.69	1	0	probably_damaging	0.97	neutral	0.87	neutral	4.67	neutral	0.79	deleterious	-9.32	low_impact	0.83	0.73	neutral	0.46	neutral	3.67	23.20	deleterious	0.33	0.5	0.71	disease	0.91	disease	0.68	disease	0.67	disease	3	0.96	neutral	0.45	neutral	-2	neutral	0.83	deleterious	-2.18	low_impact	0.69	medium_impact	-0.45	medium_impact	0.47	0.8	9.62	13.35	0.37	N	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13173	13173	C	A	MI.21029	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	837	279	C	W	tgC/tgA	4.08	1	0	probably_damaging	0.99	neutral	0.16	neutral	4.66	neutral	1.34	deleterious	-9.38	neutral_impact	0.52	0.72	neutral	0.57	neutral	4.58	24.40	deleterious	0.29	0.45	0.65	disease	0.92	disease	0.63	disease	0.56	disease	1	0.99	deleterious	0.09	neutral	-2	neutral	0.82	deleterious	-2.64	low_impact	-0.17	medium_impact	-0.73	medium_impact	0.31	0.8	9.62	13.35	0.37	N	0.96	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6013	6013	T	A	MI.2103	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	110	37	I	N	aTt/aAt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.07	deleterious	-4.14	high_impact	4.45	0.57	damaging	0.42	neutral	4.15	23.80	deleterious	0.14	0.55	0.94	disease	0.87	disease	0.56	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.64	0.9	1.75	6.65	0.54	P	0.94	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13173	13173	C	G	MI.21030	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	837	279	C	W	tgC/tgG	4.08	1	0	probably_damaging	0.99	neutral	0.16	neutral	4.66	neutral	1.34	deleterious	-9.38	neutral_impact	0.52	0.72	neutral	0.57	neutral	4.30	24.00	deleterious	0.29	0.45	0.65	disease	0.92	disease	0.63	disease	0.56	disease	1	0.99	deleterious	0.09	neutral	-2	neutral	0.82	deleterious	-2.64	low_impact	-0.17	medium_impact	-0.73	medium_impact	0.31	0.8	9.62	13.35	0.36	N	0.96	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13174	13174	T	G	MI.21031	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	838	280	L	V	Tta/Gta	-2.8	0	0	possibly_damaging	0.9	neutral	0.36	neutral	4.51	neutral	-0.92	neutral	-2.19	low_impact	0.97	0.68	neutral	0.25	damaging	3.43	23.00	deleterious	0.36	0.5	0.61	disease	0.43	neutral	0.57	disease	0.58	disease	2	0.9	neutral	0.23	neutral	-3	neutral	0.72	deleterious	-1.65	low_impact	0.1	medium_impact	-0.32	medium_impact	0.74	0.85	4.31	8.06	0.26	N	0.46	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13174	13174	T	A	MI.21032	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	838	280	L	M	Tta/Ata	-2.8	0	0	possibly_damaging	0.76	neutral	0.29	neutral	4.35	deleterious	-3.25	neutral	-1.57	medium_impact	2.56	0.64	neutral	0.27	damaging	3.59	23.20	deleterious	0.37	0.5	0.85	disease	0.56	disease	0.56	disease	0.61	disease	2	0.82	neutral	0.27	neutral	0	NA	0.75	deleterious	-1.22	low_impact	0.02	medium_impact	1.14	medium_impact	0.73	0.85	4.31	8.06	0.3	N	0.65	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13175	13175	T	C	MI.21033	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	839	280	L	S	tTa/tCa	-3.71	0	0	probably_damaging	0.98	neutral	0.43	neutral	4.35	deleterious	-4.25	deleterious	-4.83	medium_impact	2.83	0.57	damaging	0.12	damaging	3.77	23.40	deleterious	0.22	0.45	0.87	disease	0.74	disease	0.65	disease	0.71	disease	4	0.98	deleterious	0.23	neutral	1	deleterious	0.81	deleterious	-2.35	low_impact	0.17	medium_impact	1.38	medium_impact	0.71	0.85	4.31	8.06	0.22	N	0.91	polymorphism	0.97	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13175	13175	T	G	MI.21034	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	839	280	L	W	tTa/tGa	-3.71	0	0	probably_damaging	1	neutral	0.11	neutral	4.32	deleterious	-5.08	deleterious	-5.04	high_impact	4.38	0.62	neutral	0.1	damaging	3.78	23.40	deleterious	0.14	0.4	0.59	disease	0.74	disease	0.67	disease	0.66	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	-0.27	medium_impact	2.8	high_impact	0.52	0.8	4.31	8.06	0.36	N	0.95	polymorphism	0.96	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13176	13176	A	C	MI.21035	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	840	280	L	F	ttA/ttC	5.69	0.86	0	probably_damaging	0.98	neutral	0.5	neutral	4.38	neutral	-2.48	deleterious	-3.33	medium_impact	2.53	0.59	damaging	0.1	damaging	3.50	23.10	deleterious	0.44	0.55	0.79	disease	0.69	disease	0.64	disease	0.62	disease	2	0.98	neutral	0.26	neutral	1	deleterious	0.78	deleterious	-2.35	low_impact	0.23	medium_impact	1.11	medium_impact	0.72	0.85	4.31	8.06	0.4	N	0.85	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13176	13176	A	T	MI.21036	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	840	280	L	F	ttA/ttT	5.69	0.86	0	probably_damaging	0.98	neutral	0.5	neutral	4.38	neutral	-2.48	deleterious	-3.33	medium_impact	2.53	0.59	damaging	0.1	damaging	3.61	23.20	deleterious	0.44	0.55	0.79	disease	0.69	disease	0.64	disease	0.62	disease	2	0.98	neutral	0.26	neutral	1	deleterious	0.78	deleterious	-2.35	low_impact	0.23	medium_impact	1.11	medium_impact	0.72	0.85	4.31	8.06	0.4	N	0.85	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13177	13177	G	T	MI.21037	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	841	281	G	C	Ggc/Tgc	-1.88	0	0	probably_damaging	1	neutral	0.2	neutral	4.43	deleterious	-6.8	deleterious	-8.11	high_impact	4.2	0.32	damaging	0.14	damaging	4.19	23.80	deleterious	0.22	0.45	0.87	disease	0.9	disease	0.7	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.1	medium_impact	2.63	high_impact	0.43	0.8	28.86	7.22	0.56	P	0.97	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13177	13177	G	A	MI.21038	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	841	281	G	S	Ggc/Agc	-1.88	0	0	probably_damaging	1	neutral	0.46	neutral	4.62	deleterious	-3.09	deleterious	-5.41	medium_impact	2.67	0.36	damaging	0.23	damaging	4.21	23.90	deleterious	0.33	0.5	0.72	disease	0.83	disease	0.66	disease	0.69	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.19	medium_impact	1.24	medium_impact	0.61	0.8	28.86	7.22	0.51	N	1.00	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13177	13177	G	C	MI.21039	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	841	281	G	R	Ggc/Cgc	-1.88	0	0	probably_damaging	1	neutral	0.34	neutral	4.43	deleterious	-6.34	deleterious	-7.21	high_impact	5.09	0.36	damaging	0.14	damaging	3.94	23.50	deleterious	0.2	0.45	0.94	disease	0.91	disease	0.78	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.07	medium_impact	3.45	high_impact	0.58	0.8	28.86	7.22	0.69	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6013	6013	T	G	MI.2104	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	110	37	I	S	aTt/aGt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.62	neutral	-2.83	deleterious	-3.54	high_impact	5	0.7	neutral	0.5	neutral	4.02	23.60	deleterious	0.16	0.55	0.9	disease	0.88	disease	0.54	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.63	0.9	1.75	6.65	0.72	P	0.62	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13178	13178	G	T	MI.21040	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	842	281	G	V	gGc/gTc	8.9	1	0	probably_damaging	1	neutral	0.53	neutral	4.48	deleterious	-4.23	deleterious	-8.11	high_impact	4.54	0.26	damaging	0.18	damaging	3.74	23.30	deleterious	0.22	0.45	0.8	disease	0.87	disease	0.71	disease	0.7	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.26	medium_impact	2.94	high_impact	0.46	0.8	28.86	7.22	0.87	P	0.98	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13178	13178	G	A	MI.21041	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	842	281	G	D	gGc/gAc	8.9	1	0	probably_damaging	1	neutral	0.2	neutral	4.42	deleterious	-7.07	deleterious	-6.31	high_impact	5.09	0.39	damaging	0.18	damaging	3.84	23.40	deleterious	0.15	0.4	0.97	disease	0.89	disease	0.78	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.1	medium_impact	3.45	high_impact	0.37	0.8	28.86	7.22	0.8	P	0.95	disease_causing	1	0.43	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13178	13178	G	C	MI.21042	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	842	281	G	A	gGc/gCc	8.9	1	0	probably_damaging	1	neutral	0.56	neutral	4.62	neutral	-1.87	deleterious	-5.41	medium_impact	3.32	0.37	damaging	0.32	neutral	3.12	22.60	deleterious	0.33	0.5	0.54	disease	0.67	disease	0.64	disease	0.66	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.29	medium_impact	1.83	medium_impact	0.64	0.8	28.86	7.22	0.74	P	0.79	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13180	13180	G	C	MI.21043	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	844	282	A	P	Gct/Cct	-14.27	0	0	probably_damaging	1	neutral	0.21	neutral	4.48	deleterious	-5.71	deleterious	-4.45	high_impact	4.4	0.67	neutral	0.09	damaging	3.87	23.50	deleterious	0.23	0.45	0.92	disease	0.92	disease	0.73	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.09	medium_impact	2.82	high_impact	0.64	0.8	2.65	8.12	0.4	N	0.96	disease_causing	0.71	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13180	13180	G	T	MI.21044	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	844	282	A	S	Gct/Tct	-14.27	0	0	probably_damaging	1	neutral	0.48	neutral	4.59	deleterious	-3.1	deleterious	-2.6	low_impact	1.03	0.71	neutral	0.26	damaging	3.69	23.30	deleterious	0.57	0.65	0.53	disease	0.79	disease	0.44	neutral	0.42	neutral	2	1	deleterious	0.24	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.21	medium_impact	-0.26	medium_impact	0.68	0.85	2.65	8.12	0.24	N	0.98	polymorphism	0.77	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13180	13180	G	A	MI.21045	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	844	282	A	T	Gct/Act	-14.27	0	0	probably_damaging	1	neutral	0.51	neutral	4.57	neutral	-2.94	deleterious	-3.53	low_impact	1.61	0.68	neutral	0.12	damaging	4.22	23.90	deleterious	0.58	0.65	0.72	disease	0.82	disease	0.61	disease	0.61	disease	2	1	deleterious	0.26	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.24	medium_impact	0.27	medium_impact	0.65	0.8	2.65	8.12	0.19	N	0.94	polymorphism	0.59	0.07	.	.	.	.	.	.	COSM6716798	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13181	13181	C	A	MI.21046	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	845	282	A	D	gCt/gAt	5	1	0	probably_damaging	1	neutral	0.22	neutral	4.48	deleterious	-6.75	deleterious	-5.32	high_impact	4.4	0.68	neutral	0.09	damaging	4.46	24.20	deleterious	0.21	0.45	0.95	disease	0.93	disease	0.73	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.07	medium_impact	2.82	high_impact	0.59	0.8	2.65	8.12	0.57	P	0.95	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13181	13181	C	T	MI.21047	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	845	282	A	V	gCt/gTt	5	1	0	probably_damaging	1	neutral	0.57	neutral	4.69	neutral	-1.06	deleterious	-3.59	medium_impact	2.38	0.66	neutral	0.09	damaging	4.42	24.20	deleterious	0.59	0.65	0.62	disease	0.85	disease	0.62	disease	0.7	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.3	medium_impact	0.97	medium_impact	0.65	0.8	2.65	8.12	0.42	N	0.76	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13181	13181	C	G	MI.21048	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	845	282	A	G	gCt/gGt	5	1	0	probably_damaging	1	neutral	0.48	neutral	4.52	neutral	-2.32	deleterious	-3.55	low_impact	1.32	0.66	neutral	0.15	damaging	3.95	23.60	deleterious	0.5	0.6	0.73	disease	0.81	disease	0.54	disease	0.48	neutral	0	1	deleterious	0.24	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.21	medium_impact	0	medium_impact	0.75	0.85	2.65	8.12	0.39	N	0.82	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13183	13183	A	G	MI.21049	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	847	283	I	V	Atc/Gtc	-12.66	0	0.05	benign	0.04	neutral	0.41	neutral	4.58	neutral	-0.56	neutral	-0.6	low_impact	0.96	0.86	neutral	0.77	neutral	1.09	11.14	neutral	0.65	0.7	0.55	disease	0.3	neutral	0.5	neutral	0.58	disease	2	0.56	neutral	0.69	deleterious	-6	neutral	0.15	neutral	0.57	medium_impact	0.15	medium_impact	-0.33	medium_impact	0.43	0.8	5.47	9.44	0.34	N	0.56	polymorphism	1	0.01	rs879155747	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6014	6014	T	G	MI.2105	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	111	37	I	M	atT/atG	7.53	1	0	probably_damaging	1	neutral	0.12	neutral	2.72	neutral	-0.6	neutral	-1.69	medium_impact	2.85	0.57	damaging	0.69	neutral	3.26	22.80	deleterious	0.3	0.55	0.42	neutral	0.59	disease	0.28	neutral	0.44	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.29	medium_impact	1.53	medium_impact	0.77	0.9	1.75	6.65	0.59	P	0.76	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13183	13183	A	T	MI.21050	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	847	283	I	F	Atc/Ttc	-12.66	0	0.05	possibly_damaging	0.78	neutral	0.66	neutral	4.5	neutral	-1.23	deleterious	-2.82	low_impact	1.1	0.75	neutral	0.67	neutral	3.77	23.40	deleterious	0.39	0.5	0.62	disease	0.72	disease	0.56	disease	0.65	disease	3	0.74	neutral	0.44	neutral	-3	neutral	0.69	deleterious	-1.27	low_impact	0.39	medium_impact	-0.2	medium_impact	0.51	0.8	5.47	9.44	0.22	N	0.82	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13183	13183	A	C	MI.21051	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	847	283	I	L	Atc/Ctc	-12.66	0	0.05	benign	0.04	neutral	1	neutral	4.75	neutral	-0.05	neutral	-0.83	neutral_impact	-0.52	0.77	neutral	0.94	neutral	-0.72	0.06	neutral	0.37	0.5	0.44	neutral	0.13	neutral	0.28	neutral	0.24	neutral	5	0.04	neutral	0.98	deleterious	-6	neutral	0.19	neutral	0.57	medium_impact	1.89	high_impact	-1.68	low_impact	0.52	0.8	5.47	9.44	0.31	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13184	13184	T	G	MI.21052	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	848	283	I	S	aTc/aGc	-0.5	0	0	possibly_damaging	0.69	neutral	0.48	neutral	4.45	deleterious	-3.3	deleterious	-4.17	medium_impact	2.06	0.74	neutral	0.45	neutral	4.07	23.70	deleterious	0.38	0.5	0.89	disease	0.73	disease	0.61	disease	0.76	disease	5	0.67	neutral	0.4	neutral	0	NA	0.71	deleterious	-1.08	low_impact	0.21	medium_impact	0.68	medium_impact	0.39	0.8	5.47	9.44	0.23	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13184	13184	T	A	MI.21053	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	848	283	I	N	aTc/aAc	-0.5	0	0	possibly_damaging	0.87	neutral	0.25	neutral	4.42	deleterious	-5.35	deleterious	-5.07	high_impact	3.69	0.73	neutral	0.4	neutral	4.31	24.00	deleterious	0.31	0.45	0.95	disease	0.81	disease	0.64	disease	0.82	disease	6	0.91	neutral	0.19	neutral	1	deleterious	0.81	deleterious	-1.53	low_impact	-0.03	medium_impact	2.17	high_impact	0.50	0.8	5.47	9.44	0.33	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13184	13184	T	C	MI.21054	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	848	283	I	T	aTc/aCc	-0.5	0	0	benign	0.1	neutral	0.43	neutral	4.55	neutral	-2.66	deleterious	-3.17	low_impact	0.97	0.84	neutral	0.94	neutral	1.90	15.58	deleterious	0.57	0.65	0.85	disease	0.36	neutral	0.45	neutral	0.65	disease	3	0.51	neutral	0.67	deleterious	-6	neutral	0.58	deleterious	0.16	medium_impact	0.17	medium_impact	-0.32	medium_impact	0.45	0.8	5.47	9.44	0.28	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13185	13185	C	A	MI.21055	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	849	283	I	M	atC/atA	3.63	0.52	0	possibly_damaging	0.87	neutral	0.44	neutral	4.46	deleterious	-3.13	neutral	-1.3	neutral_impact	0.78	0.81	neutral	0.95	neutral	2.33	18.35	deleterious	0.43	0.55	0.8	disease	0.39	neutral	0.38	neutral	0.65	disease	3	0.87	neutral	0.29	neutral	-3	neutral	0.69	deleterious	-1.53	low_impact	0.18	medium_impact	-0.49	medium_impact	0.60	0.8	5.47	9.44	0.35	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13185	13185	C	G	MI.21056	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	849	283	I	M	atC/atG	3.63	0.52	0	possibly_damaging	0.87	neutral	0.44	neutral	4.46	deleterious	-3.13	neutral	-1.3	neutral_impact	0.78	0.81	neutral	0.95	neutral	1.88	15.47	deleterious	0.43	0.55	0.8	disease	0.39	neutral	0.38	neutral	0.65	disease	3	0.87	neutral	0.29	neutral	-3	neutral	0.69	deleterious	-1.53	low_impact	0.18	medium_impact	-0.49	medium_impact	0.60	0.8	5.47	9.44	0.34	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13186	13186	A	T	MI.21057	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	850	284	T	S	Acc/Tcc	-15.64	0	0	probably_damaging	1	neutral	0.37	neutral	4.78	neutral	-1.46	deleterious	-3.6	medium_impact	2.75	0.55	damaging	0.2	damaging	3.31	22.90	deleterious	0.32	0.5	0.51	disease	0.59	disease	0.5	neutral	0.44	neutral	1	1	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.11	medium_impact	1.31	medium_impact	0.49	0.8	28.69	7.23	0.3	N	0.89	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13186	13186	A	C	MI.21058	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	850	284	T	P	Acc/Ccc	-15.64	0	0	probably_damaging	1	neutral	0.11	neutral	4.43	deleterious	-6.57	deleterious	-5.4	high_impact	5.2	0.49	damaging	0.05	damaging	3.47	23.00	deleterious	0.19	0.45	0.88	disease	0.88	disease	0.8	disease	0.8	disease	6	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.27	medium_impact	3.55	high_impact	0.36	0.8	28.69	7.23	0.56	P	0.97	polymorphism	0.97	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13186	13186	A	G	MI.21059	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	850	284	T	A	Acc/Gcc	-15.64	0	0	probably_damaging	1	neutral	0.54	neutral	4.5	neutral	-2.99	deleterious	-4.5	high_impact	5.2	0.49	damaging	0.05	damaging	3.51	23.10	deleterious	0.33	0.5	0.82	disease	0.64	disease	0.64	disease	0.68	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.27	medium_impact	3.55	high_impact	0.42	0.8	28.69	7.23	0.58	P	0.69	polymorphism	0.99	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6014	6014	T	A	MI.2106	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	111	37	I	M	atT/atA	7.53	1	0	probably_damaging	1	neutral	0.12	neutral	2.72	neutral	-0.6	neutral	-1.69	medium_impact	2.85	0.57	damaging	0.69	neutral	3.48	23.10	deleterious	0.3	0.55	0.42	neutral	0.59	disease	0.28	neutral	0.44	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.29	medium_impact	1.53	medium_impact	0.77	0.9	1.75	6.65	0.61	P	0.76	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13187	13187	C	G	MI.21060	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	851	284	T	S	aCc/aGc	4.31	0.99	0	probably_damaging	1	neutral	0.37	neutral	4.78	neutral	-1.46	deleterious	-3.6	medium_impact	2.75	0.55	damaging	0.2	damaging	3.50	23.10	deleterious	0.32	0.5	0.51	disease	0.59	disease	0.5	neutral	0.44	neutral	1	1	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.11	medium_impact	1.31	medium_impact	0.49	0.8	28.69	7.23	0.47	N	0.89	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13187	13187	C	T	MI.21061	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	851	284	T	I	aCc/aTc	4.31	0.99	0	probably_damaging	1	neutral	0.33	neutral	4.46	deleterious	-5.01	deleterious	-5.4	high_impact	4.85	0.5	damaging	0.03	damaging	4.00	23.60	deleterious	0.35	0.5	0.95	disease	0.85	disease	0.68	disease	0.8	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.06	medium_impact	3.23	high_impact	0.59	0.8	28.69	7.23	0.65	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13187	13187	C	A	MI.21062	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	851	284	T	N	aCc/aAc	4.31	0.99	0	probably_damaging	1	neutral	0.21	neutral	4.48	deleterious	-4.46	deleterious	-4.5	high_impact	5.2	0.49	damaging	0.03	damaging	3.69	23.30	deleterious	0.31	0.45	0.84	disease	0.85	disease	0.71	disease	0.75	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.09	medium_impact	3.55	high_impact	0.60	0.8	28.69	7.23	0.68	P	0.93	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13189	13189	A	G	MI.21063	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	853	285	T	A	Act/Gct	-8.53	0	0	possibly_damaging	0.84	neutral	0.62	neutral	4.72	neutral	2.21	deleterious	-4.46	neutral_impact	-0.43	0.61	neutral	0.15	damaging	3.48	23.10	deleterious	0.6	0.65	0.4	neutral	0.36	neutral	0.57	disease	0.43	neutral	1	0.82	neutral	0.39	neutral	-3	neutral	0.68	deleterious	-1.43	low_impact	0.35	medium_impact	-1.6	low_impact	0.42	0.8	18.08	7	0.25	N	0.69	polymorphism	0.83	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13189	13189	A	C	MI.21064	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	853	285	T	P	Act/Cct	-8.53	0	0	probably_damaging	0.99	neutral	0.16	neutral	4.57	deleterious	-3.51	deleterious	-5.37	high_impact	3.54	0.49	damaging	0.04	damaging	3.47	23.00	deleterious	0.18	0.45	0.91	disease	0.89	disease	0.75	disease	0.75	disease	5	0.99	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-2.64	low_impact	-0.17	medium_impact	2.03	high_impact	0.58	0.8	18.08	7	0.3	N	0.97	disease_causing	0.52	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13189	13189	A	T	MI.21065	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	853	285	T	S	Act/Tct	-8.53	0	0	possibly_damaging	0.57	neutral	0.58	neutral	4.63	neutral	-0.44	deleterious	-3.54	neutral_impact	0.29	0.59	damaging	0.2	damaging	3.24	22.80	deleterious	0.55	0.6	0.68	disease	0.63	disease	0.54	disease	0.46	neutral	1	0.52	neutral	0.51	deleterious	-3	neutral	0.74	deleterious	-0.86	medium_impact	0.31	medium_impact	-0.94	medium_impact	0.62	0.8	18.08	7	0.19	N	0.89	polymorphism	0.93	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13190	13190	C	T	MI.21066	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	854	285	T	I	aCt/aTt	6.61	1	0	probably_damaging	0.99	neutral	0.38	neutral	4.8	neutral	1.69	deleterious	-5.37	medium_impact	2.21	0.46	damaging	0.04	damaging	3.90	23.50	deleterious	0.55	0.6	0.45	neutral	0.84	disease	0.59	disease	0.68	disease	4	0.99	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-2.64	low_impact	0.12	medium_impact	0.82	medium_impact	0.59	0.8	18.08	7	0.44	N	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13190	13190	C	G	MI.21067	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	854	285	T	S	aCt/aGt	6.61	1	0	possibly_damaging	0.57	neutral	0.58	neutral	4.63	neutral	-0.44	deleterious	-3.54	neutral_impact	0.29	0.59	damaging	0.2	damaging	3.43	23.00	deleterious	0.55	0.6	0.68	disease	0.63	disease	0.54	disease	0.46	neutral	1	0.52	neutral	0.51	deleterious	-3	neutral	0.74	deleterious	-0.86	medium_impact	0.31	medium_impact	-0.94	medium_impact	0.62	0.8	18.08	7	0.43	N	0.89	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13190	13190	C	A	MI.21068	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	854	285	T	N	aCt/aAt	6.61	1	0	probably_damaging	0.96	neutral	0.28	neutral	4.58	neutral	-2.93	deleterious	-4.46	medium_impact	3.19	0.5	damaging	0.04	damaging	3.57	23.20	deleterious	0.53	0.6	0.86	disease	0.85	disease	0.65	disease	0.74	disease	5	0.96	neutral	0.16	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	0.01	medium_impact	1.71	medium_impact	0.80	0.85	18.08	7	0.5	P	0.93	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13192	13192	C	A	MI.21069	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	856	286	L	M	Ctg/Atg	-8.07	0	0	benign	0.38	neutral	0.33	neutral	4.04	deleterious	-3.58	neutral	-1.79	medium_impact	2.13	0.77	neutral	0.68	neutral	3.76	23.40	deleterious	0.32	0.5	0.78	disease	0.46	neutral	0.37	neutral	0.63	disease	3	0.61	neutral	0.48	deleterious	-3	neutral	0.73	deleterious	-0.54	medium_impact	0.06	medium_impact	0.74	medium_impact	0.68	0.85	9.95	12.41	0.29	N	0.89	polymorphism	0.89	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6015	6015	C	G	MI.2107	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	112	38	R	G	Cga/Gga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-6.4	deleterious	-4.27	high_impact	4.44	0.47	damaging	0.08	damaging	4.03	23.70	deleterious	0.22	0.55	0.87	disease	0.74	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3	high_impact	0.49	0.9	2.73	6.99	0.42	N	0.92	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13192	13192	C	G	MI.21070	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	856	286	L	V	Ctg/Gtg	-8.07	0	0	benign	0.12	neutral	0.42	neutral	4.12	neutral	-2.43	deleterious	-2.69	low_impact	1.51	0.77	neutral	0.66	neutral	3.41	23.00	deleterious	0.31	0.5	0.55	disease	0.43	neutral	0.37	neutral	0.58	disease	2	0.51	neutral	0.65	deleterious	-6	neutral	0.71	deleterious	0.08	medium_impact	0.16	medium_impact	0.18	medium_impact	0.54	0.8	9.95	12.41	0.31	N	0.81	polymorphism	0.86	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13193	13193	T	C	MI.21071	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	857	286	L	P	cTg/cCg	-3.94	0	0	probably_damaging	0.96	neutral	0.19	neutral	3.97	deleterious	-7.24	deleterious	-6.29	high_impact	4.55	0.59	damaging	0.32	neutral	3.83	23.40	deleterious	0.18	0.45	0.96	disease	0.86	disease	0.69	disease	0.8	disease	6	0.98	neutral	0.12	neutral	2	deleterious	0.89	deleterious	-2.06	low_impact	-0.12	medium_impact	2.95	high_impact	0.68	0.85	9.95	12.41	0.39	N	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13193	13193	T	G	MI.21072	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	857	286	L	R	cTg/cGg	-3.94	0	0	probably_damaging	0.95	neutral	0.26	neutral	3.97	deleterious	-6.86	deleterious	-5.39	high_impact	4.55	0.62	neutral	0.32	neutral	4.15	23.80	deleterious	0.16	0.45	0.94	disease	0.88	disease	0.69	disease	0.79	disease	6	0.96	neutral	0.16	neutral	2	deleterious	0.90	deleterious	-1.96	low_impact	-0.02	medium_impact	2.95	high_impact	0.47	0.8	9.95	12.41	0.42	N	1.00	polymorphism	0.99	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13193	13193	T	A	MI.21073	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	857	286	L	Q	cTg/cAg	-3.94	0	0	probably_damaging	0.96	neutral	0.21	neutral	3.97	deleterious	-6.82	deleterious	-5.39	high_impact	4.55	0.66	neutral	0.39	neutral	4.04	23.70	deleterious	0.2	0.45	0.95	disease	0.81	disease	0.58	disease	0.78	disease	6	0.98	neutral	0.13	neutral	2	deleterious	0.83	deleterious	-2.06	low_impact	-0.09	medium_impact	2.95	high_impact	0.60	0.8	9.95	12.41	0.44	N	0.98	polymorphism	0.99	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13195	13195	T	A	MI.21074	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	859	287	F	I	Ttc/Atc	-0.73	0.06	0	probably_damaging	1	neutral	0.45	neutral	4.75	neutral	-0.84	deleterious	-5.39	medium_impact	2.56	0.61	neutral	0.13	damaging	4.41	24.10	deleterious	0.32	0.5	0.48	neutral	0.83	disease	0.64	disease	0.68	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.18	medium_impact	1.14	medium_impact	0.58	0.8	20.4	7.1	0.23	N	0.95	disease_causing	0.93	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13195	13195	T	C	MI.21075	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	859	287	F	L	Ttc/Ctc	-0.73	0.06	0	probably_damaging	1	neutral	0.86	neutral	4.79	neutral	0.06	deleterious	-5.39	low_impact	1.32	0.58	damaging	0.23	damaging	4.04	23.70	deleterious	0.34	0.5	0.46	neutral	0.83	disease	0.62	disease	0.63	disease	3	1	deleterious	0.43	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.67	medium_impact	0	medium_impact	0.38	0.8	20.4	7.1	0.23	N	0.92	disease_causing	0.93	0.08	.	.	.	.	.	.	COSM488742	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13195	13195	T	G	MI.21076	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	859	287	F	V	Ttc/Gtc	-0.73	0.06	0	probably_damaging	1	neutral	0.52	neutral	4.69	neutral	-0.14	deleterious	-6.29	medium_impact	2.36	0.58	damaging	0.11	damaging	4.06	23.70	deleterious	0.33	0.5	0.58	disease	0.86	disease	0.64	disease	0.71	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.25	medium_impact	0.95	medium_impact	0.38	0.8	20.4	7.1	0.2	N	0.95	disease_causing	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13196	13196	T	G	MI.21077	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	860	287	F	C	tTc/tGc	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	4.5	deleterious	-4.54	deleterious	-7.2	high_impact	3.87	0.58	damaging	0.11	damaging	4.11	23.70	deleterious	0.27	0.45	0.92	disease	0.9	disease	0.62	disease	0.8	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.12	medium_impact	2.33	high_impact	0.28	0.8	20.4	7.1	0.48	N	0.99	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13196	13196	T	A	MI.21078	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	860	287	F	Y	tTc/tAc	7.3	1	0	probably_damaging	1	neutral	1	neutral	4.61	neutral	0.37	deleterious	-2.7	low_impact	1.32	0.52	damaging	0.22	damaging	4.20	23.90	deleterious	0.3	0.45	0.5	neutral	0.78	disease	0.59	disease	0.49	neutral	0	1	deleterious	0.5	deleterious	-2	neutral	0.74	deleterious	-3.6	low_impact	1.89	high_impact	0	medium_impact	0.53	0.8	20.4	7.1	0.5	N	0.88	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13196	13196	T	C	MI.21079	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	860	287	F	S	tTc/tCc	7.3	1	0	probably_damaging	1	neutral	0.46	neutral	4.53	deleterious	-3	deleterious	-7.19	medium_impact	3.38	0.64	neutral	0.13	damaging	4.25	23.90	deleterious	0.3	0.45	0.81	disease	0.89	disease	0.64	disease	0.72	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.19	medium_impact	1.88	medium_impact	0.34	0.8	20.4	7.1	0.48	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6015	6015	C	T	MI.2108	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	112	38	R	W	Cga/Tga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-8.98	deleterious	-4.88	high_impact	5.13	0.58	damaging	0.05	damaging	4.96	25.10	deleterious	0.27	0.55	0.43	neutral	0.88	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.77	0.9	2.73	6.99	0.52	P	1.00	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13197	13197	C	A	MI.21080	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	861	287	F	L	ttC/ttA	5.46	1	0	probably_damaging	1	neutral	0.86	neutral	4.79	neutral	0.06	deleterious	-5.39	low_impact	1.32	0.58	damaging	0.23	damaging	4.69	24.60	deleterious	0.34	0.5	0.46	neutral	0.83	disease	0.62	disease	0.63	disease	3	1	deleterious	0.43	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.67	medium_impact	0	medium_impact	0.38	0.8	20.4	7.1	0.42	N	0.92	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13197	13197	C	G	MI.21081	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	861	287	F	L	ttC/ttG	5.46	1	0	probably_damaging	1	neutral	0.86	neutral	4.79	neutral	0.06	deleterious	-5.39	low_impact	1.32	0.58	damaging	0.23	damaging	4.36	24.10	deleterious	0.34	0.5	0.46	neutral	0.83	disease	0.62	disease	0.63	disease	3	1	deleterious	0.43	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.67	medium_impact	0	medium_impact	0.38	0.8	20.4	7.1	0.42	N	0.92	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13198	13198	G	T	MI.21082	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	862	288	A	S	Gca/Tca	-3.26	0	0	benign	0.36	neutral	0.41	neutral	4.53	deleterious	-3.07	neutral	0.56	low_impact	1.26	0.74	neutral	0.82	neutral	3.31	22.90	deleterious	0.34	0.5	0.63	disease	0.77	disease	0.45	neutral	0.55	disease	1	0.52	neutral	0.53	deleterious	-6	neutral	0.58	deleterious	-0.51	medium_impact	0.15	medium_impact	-0.05	medium_impact	0.64	0.8	15.26	16.68	0.33	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13198	13198	G	A	MI.21083	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	862	288	A	T	Gca/Aca	-3.26	0	0	benign	0.01	neutral	0.42	neutral	4.53	neutral	-2.44	neutral	3.7	medium_impact	2.11	0.76	neutral	0.91	neutral	-0.40	0.39	neutral	0.34	0.5	0.58	disease	0.12	neutral	0.23	neutral	0.35	neutral	3	0.57	neutral	0.71	deleterious	-3	neutral	0.17	neutral	1.15	medium_impact	0.16	medium_impact	0.73	medium_impact	0.71	0.85	15.26	16.68	0.46	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13198	13198	G	C	MI.21084	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	862	288	A	P	Gca/Cca	-3.26	0	0	possibly_damaging	0.81	neutral	0.2	neutral	4.43	deleterious	-5.37	neutral	-1.23	high_impact	4.71	0.58	damaging	0.34	neutral	3.80	23.40	deleterious	0.19	0.45	0.86	disease	0.93	disease	0.69	disease	0.81	disease	6	0.89	neutral	0.2	neutral	1	deleterious	0.87	deleterious	-1.34	low_impact	-0.1	medium_impact	3.1	high_impact	0.58	0.8	15.26	16.68	0.66	P	0.75	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13199	13199	C	A	MI.21085	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	863	288	A	E	gCa/gAa	0.87	0.02	0	possibly_damaging	0.56	neutral	0.27	neutral	4.46	deleterious	-5.14	neutral	-1.23	high_impact	4.16	0.64	neutral	0.53	neutral	4.32	24.00	deleterious	0.16	0.45	0.74	disease	0.91	disease	0.68	disease	0.76	disease	5	0.73	neutral	0.36	neutral	1	deleterious	0.76	deleterious	-0.85	medium_impact	-0.01	medium_impact	2.6	high_impact	0.59	0.8	15.26	16.68	0.42	N	0.77	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13199	13199	C	G	MI.21086	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	863	288	A	G	gCa/gGa	0.87	0.02	0	possibly_damaging	0.44	neutral	0.34	neutral	4.79	neutral	0.94	neutral	-1.97	low_impact	1.57	0.67	neutral	0.58	neutral	3.65	23.20	deleterious	0.39	0.5	0.37	neutral	0.82	disease	0.55	disease	0.72	disease	4	0.62	neutral	0.45	neutral	-3	neutral	0.56	deleterious	-0.65	medium_impact	0.07	medium_impact	0.23	medium_impact	0.70	0.85	15.26	16.68	0.37	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13199	13199	C	T	MI.21087	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	863	288	A	V	gCa/gTa	0.87	0.02	0	benign	0.36	neutral	0.51	neutral	4.49	deleterious	-3.15	neutral	-0.31	high_impact	4.71	0.67	neutral	0.67	neutral	4.10	23.70	deleterious	0.39	0.5	0.88	disease	0.78	disease	0.57	disease	0.77	disease	5	0.41	neutral	0.58	deleterious	-2	neutral	0.66	deleterious	-0.51	medium_impact	0.24	medium_impact	3.1	high_impact	0.66	0.8	15.26	16.68	0.65	P	0.47	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13201	13201	G	T	MI.21088	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	865	289	A	S	Gca/Tca	-4.63	0	0	benign	0.42	neutral	0.5	neutral	4.93	neutral	1.16	deleterious	-2.69	low_impact	1.18	0.37	damaging	0.06	damaging	3.72	23.30	deleterious	0.41	0.5	0.56	disease	0.88	disease	0.53	disease	0.51	disease	0	0.45	neutral	0.54	deleterious	-6	neutral	0.84	deleterious	-0.61	medium_impact	0.23	medium_impact	-0.13	medium_impact	0.77	0.85	25.21	7.14	0.44	N	0.98	disease_causing	0.54	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13201	13201	G	A	MI.21089	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	865	289	A	T	Gca/Aca	-4.63	0	0	probably_damaging	0.94	neutral	0.49	neutral	4.52	neutral	-0.94	deleterious	-3.59	high_impact	3.62	0.47	damaging	0.01	damaging	4.22	23.90	deleterious	0.41	0.5	0.68	disease	0.89	disease	0.57	disease	0.69	disease	4	0.93	neutral	0.28	neutral	2	deleterious	0.85	deleterious	-1.88	low_impact	0.22	medium_impact	2.1	high_impact	0.70	0.85	25.21	7.14	0.31	N	0.94	disease_causing	0.73	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6016	6016	G	A	MI.2109	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	113	38	R	Q	cGa/cAa	2.9	0.98	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.81	neutral	-2.44	high_impact	4.79	0.59	damaging	0.05	damaging	4.29	24.00	deleterious	0.41	0.55	0.7	disease	0.84	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.83	0.9	2.73	6.99	0.66	P	0.99	disease_causing	1	0.40	rs28588369	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13201	13201	G	C	MI.21090	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	865	289	A	P	Gca/Cca	-4.63	0	0	probably_damaging	0.99	neutral	0.23	neutral	4.38	deleterious	-4.14	deleterious	-4.5	high_impact	4.72	0.47	damaging	0.02	damaging	3.89	23.50	deleterious	0.18	0.45	0.93	disease	0.93	disease	0.76	disease	0.84	disease	7	0.99	deleterious	0.12	neutral	2	deleterious	0.91	deleterious	-2.64	low_impact	-0.06	medium_impact	3.11	high_impact	0.69	0.85	25.21	7.14	0.63	P	0.96	disease_causing	0.9	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13202	13202	C	A	MI.21091	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	866	289	A	E	gCa/gAa	5	1	0	probably_damaging	0.97	neutral	0.36	neutral	4.4	deleterious	-3	deleterious	-4.49	high_impact	4.72	0.51	damaging	0.02	damaging	4.50	24.30	deleterious	0.16	0.45	0.78	disease	0.94	disease	0.73	disease	0.83	disease	6	0.97	neutral	0.2	neutral	2	deleterious	0.90	deleterious	-2.18	low_impact	0.1	medium_impact	3.11	high_impact	0.61	0.8	25.21	7.14	0.7	P	0.99	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13202	13202	C	G	MI.21092	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	866	289	A	G	gCa/gGa	5	1	0	possibly_damaging	0.9	neutral	0.37	neutral	4.6	neutral	-0.27	deleterious	-3.6	low_impact	1.39	0.48	damaging	0.06	damaging	3.92	23.50	deleterious	0.36	0.5	0.65	disease	0.86	disease	0.6	disease	0.52	disease	0	0.9	neutral	0.24	neutral	-3	neutral	0.81	deleterious	-1.65	low_impact	0.11	medium_impact	0.07	medium_impact	0.72	0.85	25.21	7.14	0.45	N	0.82	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13202	13202	C	T	MI.21093	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	866	289	A	V	gCa/gTa	5	1	0	probably_damaging	0.97	neutral	0.54	neutral	4.39	deleterious	-3.6	deleterious	-3.6	high_impact	4.03	0.45	damaging	0.02	damaging	4.41	24.10	deleterious	0.5	0.6	0.77	disease	0.9	disease	0.63	disease	0.7	disease	4	0.96	neutral	0.29	neutral	2	deleterious	0.86	deleterious	-2.18	low_impact	0.27	medium_impact	2.48	high_impact	0.69	0.85	25.21	7.14	0.56	P	0.76	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13204	13204	G	C	MI.21094	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	868	290	V	L	Gtc/Ctc	-6.93	0	0.01	benign	0.08	neutral	0.54	neutral	4.93	neutral	1.5	neutral	-0.27	neutral_impact	-1.16	0.79	neutral	0.91	neutral	0.44	6.97	deleterious	0.55	0.6	0.49	neutral	0.4	neutral	0.29	neutral	0.41	neutral	2	0.39	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.26	medium_impact	0.27	medium_impact	-2.26	low_impact	0.64	0.8	11.61	13.06	0.3	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13204	13204	G	T	MI.21095	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	868	290	V	F	Gtc/Ttc	-6.93	0	0.01	possibly_damaging	0.49	neutral	0.16	neutral	4.65	neutral	-0.2	neutral	-2.28	neutral_impact	-0.13	0.77	neutral	0.74	neutral	2.25	17.84	deleterious	0.33	0.5	0.51	disease	0.76	disease	0.31	neutral	0.52	disease	0	0.82	neutral	0.34	neutral	-3	neutral	0.53	deleterious	-0.73	medium_impact	-0.17	medium_impact	-1.32	low_impact	0.51	0.8	11.61	13.06	0.29	N	0.45	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13204	13204	G	A	MI.21096	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	868	290	V	I	Gtc/Atc	-6.93	0	0.01	benign	0.01	neutral	0.27	neutral	4.73	neutral	0.08	neutral	0.68	neutral_impact	-0.62	0.83	neutral	0.97	neutral	-1.05	0.01	neutral	0.48	0.55	0.39	neutral	0.12	neutral	0.22	neutral	0.29	neutral	4	0.73	neutral	0.63	deleterious	-6	neutral	0.12	neutral	1.15	medium_impact	-0.01	medium_impact	-1.77	low_impact	0.63	0.8	11.61	13.06	0.47	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	COSM488743	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13205	13205	T	G	MI.21097	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	869	290	V	G	gTc/gGc	-0.04	0	0	possibly_damaging	0.72	neutral	0.47	neutral	4.57	deleterious	-3.39	deleterious	-5.54	low_impact	1.42	0.72	neutral	0.52	neutral	3.55	23.10	deleterious	0.29	0.45	0.75	disease	0.66	disease	0.55	disease	0.66	disease	3	0.7	neutral	0.38	neutral	-3	neutral	0.66	deleterious	-1.14	low_impact	0.2	medium_impact	0.09	medium_impact	0.55	0.8	11.61	13.06	0.24	N	0.62	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13205	13205	T	A	MI.21098	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	869	290	V	D	gTc/gAc	-0.04	0	0	possibly_damaging	0.8	neutral	0.64	neutral	4.53	deleterious	-5.3	deleterious	-4.98	medium_impact	2.66	0.68	neutral	0.47	neutral	4.50	24.30	deleterious	0.13	0.4	0.83	disease	0.78	disease	0.64	disease	0.79	disease	6	0.77	neutral	0.42	neutral	0	NA	0.78	deleterious	-1.32	low_impact	0.37	medium_impact	1.23	medium_impact	0.54	0.8	11.61	13.06	0.25	N	0.71	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13205	13205	T	C	MI.21099	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	869	290	V	A	gTc/gCc	-0.04	0	0	benign	0.25	neutral	0.91	neutral	4.59	neutral	-1.28	deleterious	-2.9	neutral_impact	-0.07	0.8	neutral	0.95	neutral	0.58	8.02	deleterious	0.49	0.55	0.56	disease	0.21	neutral	0.29	neutral	0.48	neutral	0	0.15	neutral	0.83	deleterious	-6	neutral	0.37	neutral	-0.29	medium_impact	0.79	medium_impact	-1.27	low_impact	0.36	0.8	11.61	13.06	0.27	N	0.37	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8624	8624	C	G	MI.211	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	98	33	T	S	aCc/aGc	-2.65	0	0	benign	0.07	neutral	1	neutral	4.3	neutral	0.09	neutral	-1.2	neutral_impact	-0.01	0.93	neutral	0.96	neutral	-0.54	0.18	neutral	0.6	0.7	0.28	neutral	0.17	neutral	0.42	neutral	0.26	neutral	5	0.07	neutral	0.97	deleterious	-6	neutral	0.14	neutral	0.31	medium_impact	1.98	high_impact	-1.11	low_impact	0.60	0.9	19.47	19.69	0.3	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6016	6016	G	C	MI.2110	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	113	38	R	P	cGa/cCa	2.9	0.98	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-6.94	deleterious	-4.27	high_impact	4.09	0.48	damaging	0.05	damaging	4.05	23.70	deleterious	0.18	0.55	0.9	disease	0.89	disease	0.84	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.68	high_impact	0.43	0.9	2.73	6.99	0.51	P	0.99	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13207	13207	T	G	MI.21100	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	871	291	C	G	Tgc/Ggc	-6.7	0	0	probably_damaging	1	neutral	0.37	neutral	4.74	neutral	0.71	deleterious	-10.79	low_impact	1.76	0.68	neutral	0.15	damaging	3.27	22.80	deleterious	0.47	0.55	0.6	disease	0.94	disease	0.7	disease	0.73	disease	5	1	deleterious	0.19	neutral	-2	neutral	0.85	deleterious	-3.6	low_impact	0.11	medium_impact	0.41	medium_impact	0.42	0.8	27.69	7.21	0.26	N	0.79	polymorphism	0.79	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13207	13207	T	A	MI.21101	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	871	291	C	S	Tgc/Agc	-6.7	0	0	probably_damaging	1	neutral	0.44	neutral	4.65	neutral	0.48	deleterious	-8.99	neutral_impact	0.22	0.66	neutral	0.18	damaging	3.48	23.10	deleterious	0.61	0.65	0.42	neutral	0.91	disease	0.64	disease	0.55	disease	1	1	deleterious	0.22	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.18	medium_impact	-1	low_impact	0.54	0.8	27.69	7.21	0.25	N	0.45	polymorphism	0.88	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13207	13207	T	C	MI.21102	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	871	291	C	R	Tgc/Cgc	-6.7	0	0	probably_damaging	1	neutral	0.34	neutral	4.6	neutral	-0.75	deleterious	-10.79	medium_impact	2.05	0.62	neutral	0.12	damaging	3.46	23.00	deleterious	0.53	0.6	0.8	disease	0.96	disease	0.79	disease	0.85	disease	7	1	deleterious	0.17	neutral	1	deleterious	0.93	deleterious	-3.6	low_impact	0.07	medium_impact	0.67	medium_impact	0.26	0.8	27.69	7.21	0.3	N	0.89	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13208	13208	G	A	MI.21103	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	872	291	C	Y	tGc/tAc	7.3	1	0	probably_damaging	1	neutral	1	neutral	4.63	neutral	0.08	deleterious	-9.89	medium_impact	3.06	0.68	neutral	0.1	damaging	3.61	23.20	deleterious	0.58	0.65	0.69	disease	0.96	disease	0.73	disease	0.84	disease	7	1	deleterious	0.5	deleterious	1	deleterious	0.89	deleterious	-3.6	low_impact	1.89	high_impact	1.59	medium_impact	0.54	0.8	27.69	7.21	0.37	N	0.94	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13208	13208	G	T	MI.21104	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	872	291	C	F	tGc/tTc	7.3	1	0	probably_damaging	1	neutral	0.71	neutral	4.63	neutral	0.75	deleterious	-9.89	medium_impact	2.23	0.64	neutral	0.12	damaging	3.91	23.50	deleterious	0.45	0.55	0.63	disease	0.97	disease	0.68	disease	0.8	disease	6	1	deleterious	0.36	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	0.45	medium_impact	0.83	medium_impact	0.43	0.8	27.69	7.21	0.36	N	0.95	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13208	13208	G	C	MI.21105	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	872	291	C	S	tGc/tCc	7.3	1	0	probably_damaging	1	neutral	0.44	neutral	4.65	neutral	0.48	deleterious	-8.99	neutral_impact	0.22	0.66	neutral	0.18	damaging	3.21	22.70	deleterious	0.61	0.65	0.42	neutral	0.91	disease	0.64	disease	0.55	disease	1	1	deleterious	0.22	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.18	medium_impact	-1	low_impact	0.54	0.8	27.69	7.21	0.36	N	0.45	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13209	13209	C	G	MI.21106	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	873	291	C	W	tgC/tgG	8.9	1	0	probably_damaging	1	neutral	0.18	neutral	4.58	neutral	-2.77	deleterious	-9.89	medium_impact	3.06	0.65	neutral	0.13	damaging	4.29	24.00	deleterious	0.35	0.5	0.94	disease	0.96	disease	0.76	disease	0.85	disease	7	1	deleterious	0.09	neutral	1	deleterious	0.91	deleterious	-3.6	low_impact	-0.13	medium_impact	1.59	medium_impact	0.30	0.8	27.69	7.21	0.47	N	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13209	13209	C	A	MI.21107	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	873	291	C	W	tgC/tgA	8.9	1	0	probably_damaging	1	neutral	0.18	neutral	4.58	neutral	-2.77	deleterious	-9.89	medium_impact	3.06	0.65	neutral	0.13	damaging	4.62	24.50	deleterious	0.35	0.5	0.94	disease	0.96	disease	0.76	disease	0.85	disease	7	1	deleterious	0.09	neutral	1	deleterious	0.91	deleterious	-3.6	low_impact	-0.13	medium_impact	1.59	medium_impact	0.30	0.8	27.69	7.21	0.47	N	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13210	13210	G	A	MI.21108	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	874	292	A	T	Gcc/Acc	-3.49	0	0	probably_damaging	1	neutral	0.49	neutral	4.3	deleterious	-5.24	deleterious	-3.59	high_impact	4.42	0.51	damaging	0.11	damaging	4.20	23.90	deleterious	0.31	0.45	0.78	disease	0.89	disease	0.58	disease	0.68	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.22	medium_impact	2.83	high_impact	0.74	0.85	27.36	7.24	0.4	N	0.94	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13210	13210	G	C	MI.21109	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	874	292	A	P	Gcc/Ccc	-3.49	0	0	probably_damaging	1	neutral	0.27	neutral	4.24	deleterious	-7.74	deleterious	-4.5	high_impact	5.11	0.5	damaging	0.12	damaging	3.85	23.40	deleterious	0.19	0.45	0.74	disease	0.94	disease	0.77	disease	0.86	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	-0.01	medium_impact	3.47	high_impact	0.72	0.85	27.36	7.24	0.63	P	0.96	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6016	6016	G	T	MI.2111	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	113	38	R	L	cGa/cTa	2.9	0.98	0	probably_damaging	0.99	deleterious	0	neutral	2.62	deleterious	-5.86	deleterious	-4.27	high_impact	4.79	0.59	damaging	0.05	damaging	4.14	23.80	deleterious	0.2	0.55	0.82	disease	0.91	disease	0.74	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.64	low_impact	-1.48	low_impact	3.32	high_impact	0.61	0.9	2.73	6.99	0.69	P	0.99	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13210	13210	G	T	MI.21110	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	874	292	A	S	Gcc/Tcc	-3.49	0	0	probably_damaging	1	neutral	0.42	neutral	4.35	deleterious	-4.96	deleterious	-2.7	medium_impact	2.83	0.54	damaging	0.1	damaging	3.75	23.30	deleterious	0.24	0.45	0.69	disease	0.91	disease	0.6	disease	0.71	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	0.16	medium_impact	1.38	medium_impact	0.65	0.8	27.36	7.24	0.23	N	0.98	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13211	13211	C	T	MI.21111	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	875	292	A	V	gCc/gTc	7.07	1	0	probably_damaging	1	neutral	0.56	neutral	4.32	deleterious	-4.89	deleterious	-3.6	high_impact	4.56	0.48	damaging	0.07	damaging	4.51	24.30	deleterious	0.44	0.55	0.83	disease	0.9	disease	0.66	disease	0.74	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.29	medium_impact	2.96	high_impact	0.77	0.85	27.36	7.24	0.58	P	0.76	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13211	13211	C	G	MI.21112	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	875	292	A	G	gCc/gGc	7.07	1	0	probably_damaging	1	neutral	0.35	neutral	4.54	deleterious	-3.68	deleterious	-3.6	medium_impact	2.42	0.58	damaging	0.16	damaging	4.02	23.60	deleterious	0.28	0.45	0.73	disease	0.77	disease	0.61	disease	0.54	disease	1	1	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.08	medium_impact	1.01	medium_impact	0.70	0.85	27.36	7.24	0.48	N	0.82	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13211	13211	C	A	MI.21113	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	875	292	A	D	gCc/gAc	7.07	1	0	probably_damaging	1	neutral	0.22	neutral	4.25	deleterious	-7.93	deleterious	-5.4	high_impact	5.11	0.54	damaging	0.1	damaging	4.53	24.30	deleterious	0.16	0.45	0.96	disease	0.95	disease	0.75	disease	0.84	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	-0.07	medium_impact	3.47	high_impact	0.58	0.8	27.36	7.24	0.64	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13213	13213	C	T	MI.21114	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	877	293	L	F	Ctt/Ttt	-10.6	0	0	probably_damaging	0.98	neutral	1	neutral	4.09	deleterious	-3.22	deleterious	-3.43	medium_impact	2.54	0.7	neutral	0.1	damaging	4.00	23.60	deleterious	0.5	0.6	0.76	disease	0.79	disease	0.66	disease	0.63	disease	3	0.98	deleterious	0.51	deleterious	1	deleterious	0.85	deleterious	-2.35	low_impact	1.89	high_impact	1.12	medium_impact	0.62	0.8	15.26	15.69	0.14	N	0.78	polymorphism	0.94	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13213	13213	C	A	MI.21115	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	877	293	L	I	Ctt/Att	-10.6	0	0	possibly_damaging	0.52	neutral	0.45	neutral	4.18	neutral	-1.37	neutral	-1.47	low_impact	0.98	0.79	neutral	0.9	neutral	3.02	22.30	deleterious	0.5	0.6	0.51	disease	0.48	neutral	0.29	neutral	0.4	neutral	2	0.55	neutral	0.47	neutral	-3	neutral	0.76	deleterious	-0.78	medium_impact	0.18	medium_impact	-0.31	medium_impact	0.77	0.85	15.26	15.69	0.33	N	0.09	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13213	13213	C	G	MI.21116	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	877	293	L	V	Ctt/Gtt	-10.6	0	0	possibly_damaging	0.76	neutral	0.54	neutral	4.11	neutral	-2.05	neutral	-2.36	low_impact	1.9	0.75	neutral	0.19	damaging	3.47	23.00	deleterious	0.5	0.6	0.71	disease	0.62	disease	0.51	disease	0.5	neutral	0	0.73	neutral	0.39	neutral	-3	neutral	0.81	deleterious	-1.22	low_impact	0.27	medium_impact	0.53	medium_impact	0.62	0.8	15.26	15.69	0.18	N	0.45	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13214	13214	T	G	MI.21117	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	878	293	L	R	cTt/cGt	-0.27	0	0	probably_damaging	1	neutral	0.35	neutral	4.03	deleterious	-5.22	deleterious	-5.31	high_impact	4.54	0.63	neutral	0.1	damaging	4.20	23.90	deleterious	0.2	0.45	0.9	disease	0.92	disease	0.77	disease	0.82	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	0.08	medium_impact	2.94	high_impact	0.46	0.8	15.26	15.69	0.52	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13214	13214	T	C	MI.21118	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	878	293	L	P	cTt/cCt	-0.27	0	0	probably_damaging	1	neutral	0.23	neutral	4.02	deleterious	-6.3	deleterious	-6.13	high_impact	4.18	0.64	neutral	0.1	damaging	3.87	23.50	deleterious	0.22	0.45	0.89	disease	0.89	disease	0.77	disease	0.82	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	-0.06	medium_impact	2.62	high_impact	0.60	0.8	15.26	15.69	0.39	N	0.96	polymorphism	0.74	0.29	.	.	.	.	.	.	COSM488744	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13214	13214	T	A	MI.21119	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	878	293	L	H	cTt/cAt	-0.27	0	0	probably_damaging	1	neutral	0.58	neutral	4.02	deleterious	-6.3	deleterious	-6.13	high_impact	4.54	0.68	neutral	0.1	damaging	4.09	23.70	deleterious	0.25	0.45	0.96	disease	0.85	disease	0.74	disease	0.83	disease	7	0.99	deleterious	0.29	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.31	medium_impact	2.94	high_impact	0.50	0.8	15.26	15.69	0.39	N	0.86	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6018	6018	G	A	MI.2112	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	115	39	A	T	Gcc/Acc	-7.05	0	0	benign	0.06	neutral	0.39	neutral	2.87	deleterious	-5.4	neutral	-0.55	neutral_impact	0.02	0.61	neutral	0.67	neutral	1.95	15.93	deleterious	0.38	0.55	0.4	neutral	0.17	neutral	0.17	neutral	0.33	neutral	4	0.57	neutral	0.67	deleterious	-6	neutral	0.14	neutral	0.37	medium_impact	0.09	medium_impact	-1.08	low_impact	0.66	0.9	12.09	8.96	0.5	N	0.20	polymorphism	0.93	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13216	13216	A	C	MI.21120	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	880	294	T	P	Aca/Cca	-11.28	0	0	probably_damaging	1	neutral	0.23	neutral	4.52	neutral	-2.48	deleterious	-5.4	medium_impact	3.07	0.67	neutral	0.12	damaging	3.51	23.10	deleterious	0.19	0.45	0.91	disease	0.9	disease	0.64	disease	0.75	disease	5	1	deleterious	0.12	neutral	1	deleterious	0.90	deleterious	-3.6	low_impact	-0.06	medium_impact	1.6	medium_impact	0.55	0.8	13.43	7.05	0.28	N	0.97	polymorphism	0.87	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13216	13216	A	T	MI.21121	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	880	294	T	S	Aca/Tca	-11.28	0	0	probably_damaging	1	neutral	0.46	neutral	4.65	neutral	-0.78	deleterious	-3.6	low_impact	0.98	0.69	neutral	0.21	damaging	3.28	22.80	deleterious	0.48	0.55	0.83	disease	0.77	disease	0.47	neutral	0.62	disease	2	1	deleterious	0.23	neutral	-2	neutral	0.83	deleterious	-3.6	low_impact	0.19	medium_impact	-0.31	medium_impact	0.67	0.85	13.43	7.05	0.23	N	0.89	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13216	13216	A	G	MI.21122	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	880	294	T	A	Aca/Gca	-11.28	0	0	probably_damaging	1	neutral	0.59	neutral	4.63	neutral	1.16	deleterious	-4.5	neutral_impact	0.52	0.66	neutral	0.23	damaging	3.50	23.10	deleterious	0.66	0.7	0.5	neutral	0.64	disease	0.58	disease	0.49	neutral	0	1	deleterious	0.3	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.32	medium_impact	-0.73	medium_impact	0.39	0.8	13.43	7.05	0.16	N	0.69	polymorphism	0.97	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13217	13217	C	A	MI.21123	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	881	294	T	K	aCa/aAa	6.61	1	0	probably_damaging	1	neutral	0.37	neutral	4.62	neutral	-1.1	deleterious	-5.4	low_impact	1.59	0.7	neutral	0.1	damaging	4.36	24.10	deleterious	0.32	0.5	0.73	disease	0.93	disease	0.69	disease	0.76	disease	5	1	deleterious	0.19	neutral	-2	neutral	0.87	deleterious	-3.6	low_impact	0.11	medium_impact	0.25	medium_impact	0.71	0.85	13.43	7.05	0.43	N	1.00	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13217	13217	C	T	MI.21124	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	881	294	T	M	aCa/aTa	6.61	1	0	probably_damaging	1	neutral	0.24	neutral	4.52	neutral	-1.56	deleterious	-5.4	medium_impact	2.45	0.65	neutral	0.19	damaging	3.98	23.60	deleterious	0.49	0.55	0.75	disease	0.84	disease	0.51	disease	0.64	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.04	medium_impact	1.04	medium_impact	0.73	0.85	13.43	7.05	0.44	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13219	13219	C	A	MI.21125	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	883	295	Q	K	Caa/Aaa	-4.4	0	0	probably_damaging	1	neutral	0.33	neutral	4.11	deleterious	-3.99	deleterious	-3.6	medium_impact	2.94	0.57	damaging	0.1	damaging	4.06	23.70	deleterious	0.46	0.55	0.8	disease	0.94	disease	0.67	disease	0.78	disease	6	1	deleterious	0.17	neutral	1	deleterious	0.90	deleterious	-3.6	low_impact	0.06	medium_impact	1.48	medium_impact	0.70	0.85	31.01	7.27	0.22	N	0.96	disease_causing	0.62	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13219	13219	C	G	MI.21126	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	883	295	Q	E	Caa/Gaa	-4.4	0	0	probably_damaging	1	neutral	0.28	neutral	4.15	deleterious	-3.77	deleterious	-2.7	medium_impact	2.19	0.6	damaging	0.12	damaging	3.15	22.60	deleterious	0.52	0.6	0.71	disease	0.85	disease	0.68	disease	0.65	disease	3	1	deleterious	0.14	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.01	medium_impact	0.8	medium_impact	0.64	0.8	31.01	7.27	0.22	N	0.92	polymorphism	0.56	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13220	13220	A	G	MI.21127	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	884	295	Q	R	cAa/cGa	7.07	1	0	probably_damaging	1	neutral	0.35	neutral	4.07	deleterious	-4.71	deleterious	-3.6	high_impact	3.54	0.62	neutral	0.1	damaging	3.26	22.80	deleterious	0.51	0.6	0.71	disease	0.93	disease	0.72	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.08	medium_impact	2.03	high_impact	0.53	0.8	31.01	7.27	0.52	N	0.85	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13220	13220	A	C	MI.21128	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	884	295	Q	P	cAa/cCa	7.07	1	0	probably_damaging	1	neutral	0.21	neutral	4.03	deleterious	-6.85	deleterious	-5.4	high_impact	4.89	0.5	damaging	0.13	damaging	3.19	22.70	deleterious	0.32	0.5	0.78	disease	0.93	disease	0.76	disease	0.81	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	-0.09	medium_impact	3.26	high_impact	0.57	0.8	31.01	7.27	0.66	P	0.95	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13220	13220	A	T	MI.21129	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	884	295	Q	L	cAa/cTa	7.07	1	0	probably_damaging	1	neutral	0.71	neutral	4.08	deleterious	-6.36	deleterious	-6.3	high_impact	4.34	0.51	damaging	0.09	damaging	3.62	23.20	deleterious	0.31	0.45	0.86	disease	0.93	disease	0.68	disease	0.78	disease	6	1	deleterious	0.36	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.45	medium_impact	2.76	high_impact	0.45	0.8	31.01	7.27	0.53	P	0.96	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6018	6018	G	T	MI.2113	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	115	39	A	S	Gcc/Tcc	-7.05	0	0	possibly_damaging	0.63	neutral	0.06	neutral	2.74	deleterious	-4.93	neutral	-0.84	low_impact	1.43	0.59	damaging	0.6	neutral	2.29	18.10	deleterious	0.31	0.55	0.44	neutral	0.38	neutral	0.28	neutral	0.49	neutral	0	0.94	neutral	0.22	neutral	-3	neutral	0.33	neutral	-0.97	medium_impact	-0.47	medium_impact	0.22	medium_impact	0.85	0.9	12.09	8.96	0.47	N	0.64	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13221	13221	A	T	MI.21130	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	885	295	Q	H	caA/caT	5.46	1	0.01	probably_damaging	1	neutral	0.57	neutral	4.04	deleterious	-6.19	deleterious	-4.5	medium_impact	3.4	0.49	damaging	0.2	damaging	3.56	23.10	deleterious	0.52	0.6	0.9	disease	0.87	disease	0.74	disease	0.75	disease	5	1	deleterious	0.29	neutral	1	deleterious	0.90	deleterious	-3.6	low_impact	0.3	medium_impact	1.9	medium_impact	0.64	0.8	31.01	7.27	0.6	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13221	13221	A	C	MI.21131	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	885	295	Q	H	caA/caC	5.46	1	0.01	probably_damaging	1	neutral	0.57	neutral	4.04	deleterious	-6.19	deleterious	-4.5	medium_impact	3.4	0.49	damaging	0.2	damaging	3.42	23.00	deleterious	0.52	0.6	0.9	disease	0.87	disease	0.74	disease	0.75	disease	5	1	deleterious	0.29	neutral	1	deleterious	0.90	deleterious	-3.6	low_impact	0.3	medium_impact	1.9	medium_impact	0.64	0.8	31.01	7.27	0.58	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13222	13222	A	T	MI.21132	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	886	296	N	Y	Aat/Tat	1.33	1	0	probably_damaging	1	neutral	1	neutral	4.6	neutral	-2.94	deleterious	-7.2	low_impact	1.45	0.6	neutral	0.1	damaging	3.62	23.20	deleterious	0.52	0.6	0.88	disease	0.93	disease	0.61	disease	0.74	disease	5	1	deleterious	0.5	deleterious	-2	neutral	0.90	deleterious	-3.6	low_impact	1.89	high_impact	0.12	medium_impact	0.61	0.8	30.51	7.21	0.25	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13222	13222	A	G	MI.21133	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	886	296	N	D	Aat/Gat	1.33	1	0	probably_damaging	1	neutral	0.25	neutral	4.57	neutral	-0.58	deleterious	-4.5	medium_impact	2.53	0.64	neutral	0.1	damaging	3.76	23.30	deleterious	0.74	0.75	0.67	disease	0.87	disease	0.62	disease	0.7	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.03	medium_impact	1.11	medium_impact	0.63	0.8	30.51	7.21	0.35	N	0.94	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13222	13222	A	C	MI.21134	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	886	296	N	H	Aat/Cat	1.33	1	0	probably_damaging	1	neutral	0.55	neutral	4.56	neutral	-1.81	deleterious	-4.5	low_impact	1.4	0.62	neutral	0.19	damaging	3.05	22.40	deleterious	0.61	0.65	0.76	disease	0.82	disease	0.56	disease	0.51	disease	0	1	deleterious	0.28	neutral	-2	neutral	0.85	deleterious	-3.6	low_impact	0.28	medium_impact	0.08	medium_impact	0.57	0.8	30.51	7.21	0.27	N	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13223	13223	A	C	MI.21135	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	887	296	N	T	aAt/aCt	8.44	1	0	probably_damaging	1	neutral	0.45	neutral	4.8	neutral	0.57	deleterious	-5.39	low_impact	1.59	0.6	damaging	0.09	damaging	3.40	23.00	deleterious	0.69	0.75	0.36	neutral	0.87	disease	0.59	disease	0.65	disease	3	1	deleterious	0.23	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.18	medium_impact	0.25	medium_impact	0.59	0.8	30.51	7.21	0.36	N	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13223	13223	A	T	MI.21136	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	887	296	N	I	aAt/aTt	8.44	1	0	probably_damaging	1	neutral	0.41	neutral	4.68	neutral	-2.77	deleterious	-8.1	medium_impact	2.75	0.6	neutral	0.09	damaging	3.84	23.40	deleterious	0.5	0.6	0.74	disease	0.94	disease	0.57	disease	0.74	disease	5	1	deleterious	0.21	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.15	medium_impact	1.31	medium_impact	0.38	0.8	30.51	7.21	0.41	N	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13223	13223	A	G	MI.21137	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	887	296	N	S	aAt/aGt	8.44	1	0	probably_damaging	1	neutral	0.44	neutral	4.69	neutral	-0.73	deleterious	-4.5	medium_impact	2.12	0.58	damaging	0.11	damaging	3.04	22.40	deleterious	0.73	0.75	0.6	disease	0.89	disease	0.58	disease	0.69	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.18	medium_impact	0.73	medium_impact	0.34	0.8	30.51	7.21	0.42	N	0.82	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13224	13224	T	G	MI.21138	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	888	296	N	K	aaT/aaG	8.44	1	0	probably_damaging	1	neutral	0.35	neutral	4.59	neutral	-0.33	deleterious	-5.4	medium_impact	2.59	0.61	neutral	0.09	damaging	4.06	23.70	deleterious	0.75	0.8	0.6	disease	0.92	disease	0.62	disease	0.71	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.08	medium_impact	1.16	medium_impact	0.74	0.85	30.51	7.21	0.43	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13224	13224	T	A	MI.21139	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	888	296	N	K	aaT/aaA	8.44	1	0	probably_damaging	1	neutral	0.35	neutral	4.59	neutral	-0.33	deleterious	-5.4	medium_impact	2.59	0.61	neutral	0.09	damaging	4.39	24.10	deleterious	0.75	0.8	0.6	disease	0.92	disease	0.62	disease	0.71	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.08	medium_impact	1.16	medium_impact	0.74	0.85	30.51	7.21	0.46	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6018	6018	G	C	MI.2114	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	115	39	A	P	Gcc/Ccc	-7.05	0	0	probably_damaging	0.99	neutral	0.05	neutral	2.71	deleterious	-6.77	neutral	-1.85	medium_impact	3.13	0.55	damaging	0.36	neutral	3.65	23.20	deleterious	0.1	0.55	0.73	disease	0.8	disease	0.56	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	-0.52	medium_impact	1.79	medium_impact	0.79	0.9	12.09	8.96	0.33	N	0.85	polymorphism	0.78	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13225	13225	G	A	MI.21140	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	889	297	D	N	Gac/Aac	-3.49	0	0	probably_damaging	1	neutral	0.34	neutral	4.27	neutral	-2.82	deleterious	-4.5	high_impact	4.02	0.16	damaging	0.43	neutral	4.32	24.00	deleterious	0.58	0.65	0.59	disease	0.9	disease	0.7	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.07	medium_impact	2.47	high_impact	0.57	0.8	27.69	7.23	0.92	P	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13225	13225	G	T	MI.21141	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	889	297	D	Y	Gac/Tac	-3.49	0	0	probably_damaging	1	neutral	1	neutral	4.16	deleterious	-7.43	deleterious	-8.1	high_impact	5.22	0.37	damaging	0.32	neutral	3.95	23.60	deleterious	0.23	0.45	0.96	disease	0.96	disease	0.76	disease	0.82	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.94	deleterious	-3.6	low_impact	1.89	high_impact	3.57	high_impact	0.34	0.8	27.69	7.23	0.62	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13225	13225	G	C	MI.21142	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	889	297	D	H	Gac/Cac	-3.49	0	0	probably_damaging	1	neutral	0.55	neutral	4.18	deleterious	-5.56	deleterious	-6.3	high_impact	4.33	0.39	damaging	0.31	neutral	3.64	23.20	deleterious	0.38	0.5	0.86	disease	0.91	disease	0.77	disease	0.81	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.28	medium_impact	2.75	high_impact	0.47	0.8	27.69	7.23	0.6	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13226	13226	A	G	MI.21143	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	890	297	D	G	gAc/gGc	8.9	1	0	probably_damaging	1	neutral	0.35	neutral	4.18	deleterious	-5.57	deleterious	-6.3	high_impact	4.25	0.33	damaging	0.43	neutral	4.09	23.70	deleterious	0.32	0.5	0.92	disease	0.94	disease	0.71	disease	0.81	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.08	medium_impact	2.68	high_impact	0.30	0.8	27.69	7.23	0.76	P	0.98	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13226	13226	A	C	MI.21144	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	890	297	D	A	gAc/gCc	8.9	1	0	probably_damaging	1	neutral	0.55	neutral	4.22	deleterious	-5.11	deleterious	-7.19	high_impact	5.22	0.39	damaging	0.44	neutral	3.72	23.30	deleterious	0.28	0.45	0.84	disease	0.87	disease	0.73	disease	0.77	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.28	medium_impact	3.57	high_impact	0.43	0.8	27.69	7.23	0.81	P	0.94	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13226	13226	A	T	MI.21145	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	890	297	D	V	gAc/gTc	8.9	1	0	probably_damaging	1	neutral	0.51	neutral	4.18	deleterious	-6.53	deleterious	-8.1	high_impact	5.22	0.29	damaging	0.35	neutral	3.82	23.40	deleterious	0.23	0.45	0.94	disease	0.95	disease	0.73	disease	0.81	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.24	medium_impact	3.57	high_impact	0.26	0.8	27.69	7.23	0.85	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13227	13227	C	A	MI.21146	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	891	297	D	E	gaC/gaA	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	4.25	deleterious	-3.43	deleterious	-3.6	high_impact	3.9	0.37	damaging	0.36	neutral	4.27	24.00	deleterious	0.5	0.6	0.82	disease	0.88	disease	0.68	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.03	medium_impact	2.36	high_impact	0.42	0.8	27.69	7.23	0.78	P	0.91	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13227	13227	C	G	MI.21147	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	891	297	D	E	gaC/gaG	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	4.25	deleterious	-3.43	deleterious	-3.6	high_impact	3.9	0.37	damaging	0.36	neutral	3.94	23.50	deleterious	0.5	0.6	0.82	disease	0.88	disease	0.68	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.03	medium_impact	2.36	high_impact	0.42	0.8	27.69	7.23	0.77	P	0.91	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13228	13228	A	T	MI.21148	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	892	298	I	F	Atc/Ttc	-2.11	0	0	probably_damaging	0.91	neutral	0.71	neutral	4.35	neutral	-2.82	deleterious	-3.52	medium_impact	2.44	0.54	damaging	0.07	damaging	3.70	23.30	deleterious	0.33	0.5	0.79	disease	0.88	disease	0.6	disease	0.72	disease	4	0.9	neutral	0.4	neutral	1	deleterious	0.86	deleterious	-1.7	low_impact	0.45	medium_impact	1.03	medium_impact	0.83	0.85	9.12	15.7	0.18	N	0.96	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13228	13228	A	G	MI.21149	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	892	298	I	V	Atc/Gtc	-2.11	0	0	possibly_damaging	0.62	neutral	0.51	neutral	4.46	neutral	-1.35	neutral	-0.88	medium_impact	2.6	0.55	damaging	0.22	damaging	2.99	22.20	deleterious	0.54	0.6	0.52	disease	0.56	disease	0.46	neutral	0.46	neutral	1	0.6	neutral	0.45	neutral	0	NA	0.71	deleterious	-0.95	medium_impact	0.24	medium_impact	1.17	medium_impact	0.67	0.85	9.12	15.7	0.31	N	0.74	disease_causing	0.55	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6019	6019	C	A	MI.2115	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	116	39	A	D	gCc/gAc	3.13	1	0	probably_damaging	0.98	deleterious	0.01	neutral	2.71	deleterious	-6.7	neutral	-2.25	medium_impact	3.48	0.59	damaging	0.37	neutral	4.34	24.10	deleterious	0.12	0.55	0.77	disease	0.73	disease	0.54	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-2.35	low_impact	-0.92	medium_impact	2.11	high_impact	0.65	0.9	12.09	8.96	0.47	N	0.89	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13228	13228	A	C	MI.21150	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	892	298	I	L	Atc/Ctc	-2.11	0	0	benign	0.08	neutral	0.67	neutral	4.6	neutral	-0.19	neutral	-1.69	neutral_impact	0.62	0.5	damaging	0.11	damaging	3.69	23.30	deleterious	0.35	0.5	0.41	neutral	0.57	disease	0.4	neutral	0.43	neutral	1	0.24	neutral	0.8	deleterious	-6	neutral	0.70	deleterious	0.26	medium_impact	0.4	medium_impact	-0.64	medium_impact	0.77	0.85	9.12	15.7	0.26	N	0.86	disease_causing	0.74	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13229	13229	T	G	MI.21151	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	893	298	I	S	aTc/aGc	5.46	1	0	possibly_damaging	0.9	neutral	0.41	neutral	4.33	deleterious	-4.49	deleterious	-5.3	high_impact	3.98	0.52	damaging	0.15	damaging	4.35	24.10	deleterious	0.26	0.45	0.81	disease	0.92	disease	0.61	disease	0.73	disease	5	0.9	neutral	0.26	neutral	1	deleterious	0.89	deleterious	-1.65	low_impact	0.15	medium_impact	2.43	high_impact	0.54	0.8	9.12	15.7	0.53	P	0.96	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13229	13229	T	A	MI.21152	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	893	298	I	N	aTc/aAc	5.46	1	0	probably_damaging	0.98	neutral	0.32	neutral	4.3	deleterious	-5.86	deleterious	-6.2	high_impact	4.54	0.51	damaging	0.05	damaging	4.50	24.30	deleterious	0.29	0.45	0.93	disease	0.9	disease	0.6	disease	0.81	disease	6	0.98	neutral	0.17	neutral	2	deleterious	0.89	deleterious	-2.35	low_impact	0.05	medium_impact	2.94	high_impact	0.54	0.8	9.12	15.7	0.51	P	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13229	13229	T	C	MI.21153	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	893	298	I	T	aTc/aCc	5.46	1	0	possibly_damaging	0.9	neutral	0.41	neutral	4.36	deleterious	-3.87	deleterious	-4.42	high_impact	4.19	0.5	damaging	0.05	damaging	3.49	23.10	deleterious	0.42	0.55	0.64	disease	0.83	disease	0.58	disease	0.67	disease	3	0.9	neutral	0.26	neutral	1	deleterious	0.84	deleterious	-1.65	low_impact	0.15	medium_impact	2.62	high_impact	0.63	0.8	9.12	15.7	0.53	P	0.96	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13230	13230	C	G	MI.21154	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	894	298	I	M	atC/atG	7.3	1	0	possibly_damaging	0.49	neutral	0.22	neutral	4.41	neutral	-2.34	deleterious	-2.53	low_impact	1.34	0.52	damaging	0.12	damaging	3.35	22.90	deleterious	0.5	0.6	0.68	disease	0.71	disease	0.43	neutral	0.54	disease	1	0.76	neutral	0.37	neutral	-3	neutral	0.78	deleterious	-0.73	medium_impact	-0.07	medium_impact	0.02	medium_impact	0.85	0.9	9.12	15.7	0.5	P	0.76	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13230	13230	C	A	MI.21155	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	894	298	I	M	atC/atA	7.3	1	0	possibly_damaging	0.49	neutral	0.22	neutral	4.41	neutral	-2.34	deleterious	-2.53	low_impact	1.34	0.52	damaging	0.12	damaging	3.83	23.40	deleterious	0.5	0.6	0.68	disease	0.71	disease	0.43	neutral	0.54	disease	1	0.76	neutral	0.37	neutral	-3	neutral	0.78	deleterious	-0.73	medium_impact	-0.07	medium_impact	0.02	medium_impact	0.85	0.9	9.12	15.7	0.51	P	0.76	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13231	13231	A	C	MI.21156	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	895	299	K	Q	Aaa/Caa	-4.63	0	0	probably_damaging	1	neutral	0.31	neutral	3.2	deleterious	-7.28	deleterious	-3.6	high_impact	5.25	0.43	damaging	0.18	damaging	3.51	23.10	deleterious	0.26	0.45	0.91	disease	0.84	disease	0.62	disease	0.8	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.04	medium_impact	3.59	high_impact	0.51	0.8	22.72	7.09	0.61	P	0.82	disease_causing	0.98	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13231	13231	A	G	MI.21157	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	895	299	K	E	Aaa/Gaa	-4.63	0	0	probably_damaging	1	neutral	0.24	neutral	3.18	deleterious	-7.31	deleterious	-3.6	high_impact	5.25	0.43	damaging	0.18	damaging	4.09	23.70	deleterious	0.21	0.45	0.96	disease	0.87	disease	0.72	disease	0.81	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	-0.04	medium_impact	3.59	high_impact	0.51	0.8	22.72	7.09	0.65	P	0.84	disease_causing	0.99	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13232	13232	A	T	MI.21158	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	896	299	K	M	aAa/aTa	8.44	1	0	probably_damaging	1	neutral	0.25	neutral	3.16	deleterious	-8.44	deleterious	-5.4	high_impact	5.25	0.45	damaging	0.18	damaging	4.03	23.70	deleterious	0.19	0.45	0.96	disease	0.83	disease	0.69	disease	0.8	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.03	medium_impact	3.59	high_impact	0.50	0.8	22.72	7.09	0.66	P	0.40	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13232	13232	A	C	MI.21159	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	896	299	K	T	aAa/aCa	8.44	1	0	probably_damaging	1	neutral	0.48	neutral	3.17	deleterious	-8.22	deleterious	-5.39	high_impact	5.25	0.38	damaging	0.17	damaging	3.70	23.30	deleterious	0.2	0.45	0.97	disease	0.84	disease	0.65	disease	0.8	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.21	medium_impact	3.59	high_impact	0.41	0.8	22.72	7.09	0.75	P	0.75	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6019	6019	C	G	MI.2116	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	116	39	A	G	gCc/gGc	3.13	1	0	benign	0.38	deleterious	0.01	neutral	2.72	deleterious	-5.6	neutral	-1.84	low_impact	1.77	0.6	damaging	0.51	neutral	2.40	18.81	deleterious	0.22	0.55	0.66	disease	0.36	neutral	0.39	neutral	0.62	disease	2	0.99	deleterious	0.32	neutral	-2	neutral	0.32	neutral	-0.56	medium_impact	-0.92	medium_impact	0.54	medium_impact	0.77	0.9	12.09	8.96	0.5	P	0.56	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13233	13233	A	C	MI.21160	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	897	299	K	N	aaA/aaC	8.44	1	0	probably_damaging	1	neutral	0.31	neutral	3.17	deleterious	-7.78	deleterious	-4.5	high_impact	5.25	0.35	damaging	0.15	damaging	3.76	23.30	deleterious	0.23	0.45	0.97	disease	0.83	disease	0.69	disease	0.81	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.04	medium_impact	3.59	high_impact	0.49	0.8	22.72	7.09	0.76	P	0.63	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13233	13233	A	T	MI.21161	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	897	299	K	N	aaA/aaT	8.44	1	0	probably_damaging	1	neutral	0.31	neutral	3.17	deleterious	-7.78	deleterious	-4.5	high_impact	5.25	0.35	damaging	0.15	damaging	3.83	23.40	deleterious	0.23	0.45	0.97	disease	0.83	disease	0.69	disease	0.81	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.04	medium_impact	3.59	high_impact	0.49	0.8	22.72	7.09	0.77	P	0.63	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13234	13234	A	G	MI.21162	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	898	300	K	E	Aaa/Gaa	2.71	1	0	probably_damaging	1	neutral	0.34	neutral	4.39	neutral	-1.99	deleterious	-3.6	high_impact	3.67	0.42	damaging	0.2	damaging	3.74	23.30	deleterious	0.31	0.45	0.76	disease	0.85	disease	0.63	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.07	medium_impact	2.15	high_impact	0.63	0.8	29.02	7.19	0.66	P	0.84	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13234	13234	A	C	MI.21163	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	898	300	K	Q	Aaa/Caa	2.71	1	0	probably_damaging	1	neutral	0.34	neutral	4.35	neutral	-2.45	deleterious	-3.6	high_impact	3.63	0.43	damaging	0.16	damaging	3.24	22.80	deleterious	0.31	0.45	0.81	disease	0.82	disease	0.64	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.07	medium_impact	2.11	high_impact	0.72	0.85	29.02	7.19	0.6	P	0.82	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13235	13235	A	C	MI.21164	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	899	300	K	T	aAa/aCa	8.44	1	0	probably_damaging	1	neutral	0.45	neutral	4.34	neutral	-2.87	deleterious	-5.4	high_impact	4.61	0.39	damaging	0.15	damaging	3.44	23.00	deleterious	0.27	0.45	0.79	disease	0.83	disease	0.66	disease	0.72	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.18	medium_impact	3.01	high_impact	0.46	0.8	29.02	7.19	0.73	P	0.75	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13235	13235	A	T	MI.21165	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	899	300	K	M	aAa/aTa	8.44	1	0	probably_damaging	1	neutral	0.23	neutral	4.32	deleterious	-4.55	deleterious	-5.4	high_impact	4.61	0.43	damaging	0.18	damaging	3.70	23.30	deleterious	0.19	0.45	0.6	disease	0.82	disease	0.64	disease	0.68	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	-0.06	medium_impact	3.01	high_impact	0.52	0.8	29.02	7.19	0.68	P	0.40	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13236	13236	A	C	MI.21166	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	900	300	K	N	aaA/aaC	6.84	1	0	probably_damaging	1	neutral	0.34	neutral	4.38	deleterious	-3.18	deleterious	-4.5	high_impact	4.95	0.32	damaging	0.15	damaging	3.84	23.40	deleterious	0.36	0.5	0.84	disease	0.82	disease	0.65	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.07	medium_impact	3.32	high_impact	0.58	0.8	29.02	7.19	0.81	P	0.63	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13236	13236	A	T	MI.21167	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	900	300	K	N	aaA/aaT	6.84	1	0	probably_damaging	1	neutral	0.34	neutral	4.38	deleterious	-3.18	deleterious	-4.5	high_impact	4.95	0.32	damaging	0.15	damaging	3.90	23.50	deleterious	0.36	0.5	0.84	disease	0.82	disease	0.65	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.07	medium_impact	3.32	high_impact	0.58	0.8	29.02	7.19	0.82	P	0.63	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13237	13237	A	T	MI.21168	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	901	301	I	F	Atc/Ttc	2.02	1	0	probably_damaging	0.97	neutral	0.78	neutral	4.46	neutral	-2.72	deleterious	-3.6	high_impact	4.43	0.69	neutral	0.41	neutral	3.65	23.20	deleterious	0.34	0.5	0.68	disease	0.85	disease	0.62	disease	0.7	disease	4	0.97	neutral	0.41	neutral	2	deleterious	0.82	deleterious	-2.18	low_impact	0.54	medium_impact	2.84	high_impact	0.81	0.85	24.21	7.37	0.47	N	0.96	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13237	13237	A	G	MI.21169	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	901	301	I	V	Atc/Gtc	2.02	1	0	benign	0.18	neutral	0.53	neutral	4.67	neutral	0.36	neutral	-0.9	low_impact	0.9	0.76	neutral	0.7	neutral	2.96	22.10	deleterious	0.52	0.6	0.48	neutral	0.29	neutral	0.51	disease	0.4	neutral	2	0.36	neutral	0.68	deleterious	-6	neutral	0.67	deleterious	-0.12	medium_impact	0.26	medium_impact	-0.38	medium_impact	0.74	0.85	24.21	7.37	0.4	N	0.74	disease_causing	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6019	6019	C	T	MI.2117	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	116	39	A	V	gCc/gTc	3.13	1	0	possibly_damaging	0.5	neutral	0.54	neutral	2.83	deleterious	-5.74	neutral	-0.49	low_impact	1.31	0.61	neutral	0.41	neutral	0.99	10.58	neutral	0.31	0.55	0.26	neutral	0.39	neutral	0.24	neutral	0.46	neutral	1	0.48	neutral	0.52	deleterious	-3	neutral	0.52	deleterious	-0.76	medium_impact	0.23	medium_impact	0.11	medium_impact	0.75	0.9	12.09	8.96	0.51	N	0.75	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13237	13237	A	C	MI.21170	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	901	301	I	L	Atc/Ctc	2.02	1	0	possibly_damaging	0.61	neutral	0.74	neutral	4.77	neutral	1.21	neutral	-1.8	medium_impact	2.58	0.7	neutral	0.46	neutral	3.66	23.20	deleterious	0.29	0.45	0.41	neutral	0.69	disease	0.56	disease	0.63	disease	3	0.53	neutral	0.57	deleterious	0	NA	0.69	deleterious	-0.93	medium_impact	0.48	medium_impact	1.15	medium_impact	0.78	0.85	24.21	7.37	0.38	N	0.86	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13238	13238	T	G	MI.21171	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	902	301	I	S	aTc/aGc	6.61	1	0	probably_damaging	0.96	neutral	0.45	neutral	4.46	deleterious	-3	deleterious	-5.39	high_impact	3.73	0.71	neutral	0.56	neutral	4.36	24.10	deleterious	0.3	0.45	0.71	disease	0.9	disease	0.61	disease	0.71	disease	4	0.96	neutral	0.25	neutral	2	deleterious	0.85	deleterious	-2.06	low_impact	0.18	medium_impact	2.2	high_impact	0.50	0.8	24.21	7.37	0.56	P	0.96	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13238	13238	T	C	MI.21172	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	902	301	I	T	aTc/aCc	6.61	1	0	probably_damaging	0.91	neutral	0.44	neutral	4.45	neutral	-2.87	deleterious	-4.5	medium_impact	3.19	0.7	neutral	0.45	neutral	3.51	23.10	deleterious	0.49	0.55	0.72	disease	0.79	disease	0.61	disease	0.66	disease	3	0.91	neutral	0.27	neutral	1	deleterious	0.82	deleterious	-1.7	low_impact	0.18	medium_impact	1.71	medium_impact	0.60	0.8	24.21	7.37	0.5	N	0.96	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13238	13238	T	A	MI.21173	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	902	301	I	N	aTc/aAc	6.61	1	0	probably_damaging	0.98	neutral	0.34	neutral	4.41	deleterious	-4.65	deleterious	-6.3	high_impact	4.08	0.66	neutral	0.49	neutral	4.58	24.40	deleterious	0.33	0.5	0.93	disease	0.89	disease	0.63	disease	0.81	disease	6	0.99	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-2.35	low_impact	0.07	medium_impact	2.52	high_impact	0.61	0.8	24.21	7.37	0.56	P	0.99	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13239	13239	C	A	MI.21174	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	903	301	I	M	atC/atA	4.54	1	0	probably_damaging	0.97	neutral	0.25	neutral	4.45	neutral	-0.58	deleterious	-2.7	medium_impact	3.46	0.7	neutral	0.55	neutral	3.89	23.50	deleterious	0.42	0.55	0.65	disease	0.73	disease	0.6	disease	0.64	disease	3	0.98	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-2.18	low_impact	-0.03	medium_impact	1.96	medium_impact	0.90	0.95	24.21	7.37	0.47	N	0.76	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13239	13239	C	G	MI.21175	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	903	301	I	M	atC/atG	4.54	1	0	probably_damaging	0.97	neutral	0.25	neutral	4.45	neutral	-0.58	deleterious	-2.7	medium_impact	3.46	0.7	neutral	0.55	neutral	3.38	23.00	deleterious	0.42	0.55	0.65	disease	0.73	disease	0.6	disease	0.64	disease	3	0.98	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-2.18	low_impact	-0.03	medium_impact	1.96	medium_impact	0.90	0.95	24.21	7.37	0.47	N	0.76	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13240	13240	G	T	MI.21176	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	904	302	V	L	Gta/Tta	-5.32	0	0	probably_damaging	1	neutral	0.73	neutral	4.93	neutral	3.28	neutral	-1.86	neutral_impact	0.76	0.77	neutral	0.16	damaging	3.68	23.30	deleterious	0.37	0.5	0.49	neutral	0.74	disease	0.58	disease	0.67	disease	3	1	deleterious	0.37	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.47	medium_impact	-0.51	medium_impact	0.70	0.85	2.49	11.16	0.2	N	0.59	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13240	13240	G	C	MI.21177	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	904	302	V	L	Gta/Cta	-5.32	0	0	probably_damaging	1	neutral	0.73	neutral	4.93	neutral	3.28	neutral	-1.86	neutral_impact	0.76	0.77	neutral	0.16	damaging	3.52	23.10	deleterious	0.37	0.5	0.49	neutral	0.74	disease	0.58	disease	0.67	disease	3	1	deleterious	0.37	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.47	medium_impact	-0.51	medium_impact	0.70	0.85	2.49	11.16	0.2	N	0.59	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13240	13240	G	A	MI.21178	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	904	302	V	M	Gta/Ata	-5.32	0	0	probably_damaging	1	neutral	0.24	neutral	4.54	neutral	-1.67	neutral	-2.28	medium_impact	2.92	0.72	neutral	0.13	damaging	3.74	23.30	deleterious	0.33	0.5	0.42	neutral	0.75	disease	0.51	disease	0.59	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	-0.04	medium_impact	1.46	medium_impact	0.66	0.8	2.49	11.16	0.28	N	0.47	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13241	13241	T	A	MI.21179	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	905	302	V	E	gTa/gAa	-0.73	0	0	probably_damaging	1	neutral	0.28	neutral	4.41	deleterious	-4.23	deleterious	-5.4	high_impact	3.61	0.68	neutral	0.12	damaging	4.67	24.50	deleterious	0.11	0.4	0.93	disease	0.91	disease	0.69	disease	0.82	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.01	medium_impact	2.1	high_impact	0.44	0.8	2.49	11.16	0.3	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6021	6021	G	C	MI.2118	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	118	40	E	Q	Gag/Cag	-7.97	0	0	probably_damaging	1	deleterious	0.01	neutral	2.8	neutral	-1.38	neutral	-1.73	medium_impact	3.29	0.48	damaging	0.48	neutral	3.19	22.70	deleterious	0.42	0.55	0.31	neutral	0.73	disease	0.4	neutral	0.5	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	1.94	medium_impact	0.75	0.9	2.34	6.73	0.48	N	0.66	polymorphism	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13241	13241	T	G	MI.21180	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	905	302	V	G	gTa/gGa	-0.73	0	0	probably_damaging	1	neutral	0.34	neutral	4.41	deleterious	-3.95	deleterious	-6.3	high_impact	3.61	0.69	neutral	0.14	damaging	3.84	23.40	deleterious	0.18	0.45	0.91	disease	0.84	disease	0.61	disease	0.81	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.07	medium_impact	2.1	high_impact	0.44	0.8	2.49	11.16	0.29	N	0.93	polymorphism	0.92	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13241	13241	T	C	MI.21181	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	905	302	V	A	gTa/gCa	-0.73	0	0	probably_damaging	1	neutral	0.54	neutral	4.46	neutral	-1.98	deleterious	-3.6	high_impact	3.61	0.72	neutral	0.16	damaging	3.59	23.20	deleterious	0.22	0.45	0.71	disease	0.61	disease	0.57	disease	0.67	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.27	medium_impact	2.1	high_impact	0.51	0.8	2.49	11.16	0.24	N	0.81	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13243	13243	G	C	MI.21182	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	907	303	A	P	Gcc/Ccc	-11.74	0	0	probably_damaging	1	neutral	0.21	neutral	2.89	deleterious	-10.32	deleterious	-4.51	high_impact	5.24	0.34	damaging	0.15	damaging	3.81	23.40	deleterious	0.13	0.4	0.98	disease	0.89	disease	0.79	disease	0.87	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.09	medium_impact	3.58	high_impact	0.66	0.8	25.37	7.29	0.59	P	0.96	disease_causing	0.61	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13243	13243	G	T	MI.21183	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	907	303	A	S	Gcc/Tcc	-11.74	0	0	probably_damaging	1	neutral	0.46	neutral	2.93	deleterious	-6.66	deleterious	-2.7	high_impact	3.71	0.33	damaging	0.15	damaging	3.71	23.30	deleterious	0.18	0.45	0.87	disease	0.86	disease	0.65	disease	0.76	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.19	medium_impact	2.19	high_impact	0.74	0.85	25.37	7.29	0.45	N	0.98	polymorphism	0.84	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13243	13243	G	A	MI.21184	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	907	303	A	T	Gcc/Acc	-11.74	0	0	probably_damaging	1	neutral	0.47	neutral	2.92	deleterious	-8.49	deleterious	-3.6	high_impact	5.24	0.33	damaging	0.12	damaging	4.27	23.90	deleterious	0.15	0.4	0.92	disease	0.85	disease	0.69	disease	0.8	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.2	medium_impact	3.58	high_impact	0.54	0.8	25.37	7.29	0.57	P	0.94	polymorphism	0.69	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13244	13244	C	T	MI.21185	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	908	303	A	V	gCc/gTc	8.9	1	0	probably_damaging	1	neutral	0.52	neutral	2.95	deleterious	-8.67	deleterious	-3.61	high_impact	5.24	0.25	damaging	0.09	damaging	4.46	24.20	deleterious	0.2	0.45	0.91	disease	0.85	disease	0.69	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.25	medium_impact	3.58	high_impact	0.61	0.8	25.37	7.29	0.83	P	0.76	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13244	13244	C	A	MI.21186	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	908	303	A	D	gCc/gAc	8.9	1	0	probably_damaging	1	neutral	0.27	neutral	2.88	deleterious	-11.71	deleterious	-5.41	high_impact	5.24	0.46	damaging	0.12	damaging	4.67	24.50	deleterious	0.11	0.4	0.98	disease	0.92	disease	0.76	disease	0.85	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.01	medium_impact	3.58	high_impact	0.60	0.8	25.37	7.29	0.63	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13244	13244	C	G	MI.21187	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	908	303	A	G	gCc/gGc	8.9	1	0	probably_damaging	1	neutral	0.35	neutral	2.99	deleterious	-6.96	deleterious	-3.61	high_impact	5.24	0.32	damaging	0.15	damaging	3.99	23.60	deleterious	0.18	0.45	0.95	disease	0.81	disease	0.62	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.08	medium_impact	3.58	high_impact	0.75	0.85	25.37	7.29	0.78	P	0.82	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13246	13246	T	A	MI.21188	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	910	304	F	I	Ttc/Atc	-7.61	0	0	probably_damaging	1	neutral	0.48	neutral	4.6	neutral	-2.36	deleterious	-5.12	high_impact	4.05	0.76	neutral	0.63	neutral	4.45	24.20	deleterious	0.18	0.45	0.56	disease	0.84	disease	0.73	disease	0.75	disease	5	1	deleterious	0.24	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.21	medium_impact	2.5	high_impact	0.58	0.8	7.3	9.97	0.33	N	0.95	polymorphism	0.52	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13246	13246	T	C	MI.21189	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	910	304	F	L	Ttc/Ctc	-7.61	0	0	probably_damaging	1	neutral	0.71	neutral	4.68	neutral	-1.54	deleterious	-5.05	neutral_impact	0.24	0.74	neutral	0.8	neutral	4.08	23.70	deleterious	0.4	0.5	0.45	neutral	0.72	disease	0.66	disease	0.53	disease	1	1	deleterious	0.36	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.45	medium_impact	-0.98	medium_impact	0.73	0.85	7.3	9.97	0.25	N	0.92	disease_causing	0.51	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6021	6021	G	A	MI.2119	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	118	40	E	K	Gag/Aag	-7.97	0	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-2.68	neutral	-2.33	high_impact	3.74	0.41	damaging	0.3	neutral	4.31	24.00	deleterious	0.41	0.55	0.5	disease	0.89	disease	0.62	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.35	high_impact	0.64	0.9	2.34	6.73	0.51	N	0.72	polymorphism	0.9	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13246	13246	T	G	MI.21190	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	910	304	F	V	Ttc/Gtc	-7.61	0	0	probably_damaging	1	neutral	0.52	neutral	4.6	neutral	-2.14	deleterious	-6.03	high_impact	4.05	0.73	neutral	0.54	neutral	4.17	23.80	deleterious	0.24	0.45	0.68	disease	0.88	disease	0.7	disease	0.74	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.25	medium_impact	2.5	high_impact	0.59	0.8	7.3	9.97	0.33	N	0.95	disease_causing	0.67	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13247	13247	T	G	MI.21191	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	911	304	F	C	tTc/tGc	5.69	1	0	probably_damaging	1	neutral	0.19	neutral	4.54	deleterious	-3.52	deleterious	-6.96	high_impact	4.05	0.73	neutral	0.5	neutral	4.14	23.80	deleterious	0.26	0.45	0.91	disease	0.89	disease	0.75	disease	0.82	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.12	medium_impact	2.5	high_impact	0.48	0.8	7.3	9.97	0.57	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13247	13247	T	A	MI.21192	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	911	304	F	Y	tTc/tAc	5.69	1	0	probably_damaging	1	neutral	1	neutral	5.02	neutral	3.32	deleterious	-2.63	neutral_impact	-0.21	0.62	neutral	0.68	neutral	4.24	23.90	deleterious	0.22	0.45	0.49	neutral	0.54	disease	0.73	disease	0.59	disease	2	1	deleterious	0.5	deleterious	-2	neutral	0.74	deleterious	-3.6	low_impact	1.89	high_impact	-1.39	low_impact	0.72	0.85	7.3	9.97	0.48	N	0.88	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13247	13247	T	C	MI.21193	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	911	304	F	S	tTc/tCc	5.69	1	0	probably_damaging	1	neutral	0.49	neutral	4.54	neutral	-2.71	deleterious	-7	high_impact	3.7	0.84	neutral	0.62	neutral	4.23	23.90	deleterious	0.22	0.45	0.82	disease	0.88	disease	0.72	disease	0.76	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.22	medium_impact	2.18	high_impact	0.47	0.8	7.3	9.97	0.59	P	0.97	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13248	13248	C	G	MI.21194	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	912	304	F	L	ttC/ttG	5.69	1	0	probably_damaging	1	neutral	0.71	neutral	4.68	neutral	-1.54	deleterious	-5.05	neutral_impact	0.24	0.74	neutral	0.8	neutral	4.41	24.10	deleterious	0.4	0.5	0.45	neutral	0.72	disease	0.66	disease	0.53	disease	1	1	deleterious	0.36	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.45	medium_impact	-0.98	medium_impact	0.73	0.85	7.3	9.97	0.45	N	0.92	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13248	13248	C	A	MI.21195	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	912	304	F	L	ttC/ttA	5.69	1	0	probably_damaging	1	neutral	0.71	neutral	4.68	neutral	-1.54	deleterious	-5.05	neutral_impact	0.24	0.74	neutral	0.8	neutral	4.66	24.50	deleterious	0.4	0.5	0.45	neutral	0.72	disease	0.66	disease	0.53	disease	1	1	deleterious	0.36	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.45	medium_impact	-0.98	medium_impact	0.73	0.85	7.3	9.97	0.45	N	0.92	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13249	13249	T	A	MI.21196	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	913	305	S	T	Tcc/Acc	-0.73	0.04	0	probably_damaging	1	neutral	0.44	neutral	2.47	deleterious	-7.09	deleterious	-2.7	high_impact	3.67	0.36	damaging	0.12	damaging	3.76	23.30	deleterious	0.2	0.45	0.83	disease	0.73	disease	0.76	disease	0.77	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.18	medium_impact	2.15	high_impact	0.68	0.85	28.52	7.39	0.58	P	0.71	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13249	13249	T	C	MI.21197	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	913	305	S	P	Tcc/Ccc	-0.73	0.04	0	probably_damaging	1	neutral	0.2	neutral	2.45	deleterious	-8.54	deleterious	-4.51	high_impact	4.5	0.36	damaging	0.19	damaging	3.95	23.60	deleterious	0.17	0.45	0.97	disease	0.86	disease	0.84	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.1	medium_impact	2.91	high_impact	0.62	0.8	28.52	7.39	0.66	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13249	13249	T	G	MI.21198	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	913	305	S	A	Tcc/Gcc	-0.73	0.04	0	probably_damaging	1	neutral	0.56	neutral	2.51	deleterious	-6.22	deleterious	-2.7	high_impact	4.5	0.37	damaging	0.16	damaging	3.66	23.20	deleterious	0.22	0.45	0.84	disease	0.63	disease	0.76	disease	0.72	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.29	medium_impact	2.91	high_impact	0.74	0.85	28.52	7.39	0.64	P	0.49	disease_causing	0.97	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13250	13250	C	T	MI.21199	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	914	305	S	F	tCc/tTc	7.3	1	0	probably_damaging	1	neutral	0.76	neutral	2.44	deleterious	-9.94	deleterious	-5.41	high_impact	4.85	0.28	damaging	0.09	damaging	4.29	24.00	deleterious	0.17	0.45	0.93	disease	0.89	disease	0.77	disease	0.84	disease	7	1	deleterious	0.38	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.51	medium_impact	3.23	high_impact	0.37	0.8	28.52	7.39	0.72	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8626	8626	T	C	MI.212	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	100	34	S	P	Tcc/Ccc	-6.12	0	0	probably_damaging	0.99	neutral	0.62	neutral	4.28	neutral	-2.38	neutral	1.89	neutral_impact	-0.82	0.89	neutral	0.95	neutral	1.74	14.66	neutral	0.42	0.65	0.33	neutral	0.65	disease	0.25	neutral	0.43	neutral	1	0.99	deleterious	0.32	neutral	-2	neutral	0.72	deleterious	-2.65	low_impact	0.41	medium_impact	-1.8	low_impact	0.52	0.9	9.73	14.65	0.22	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6022	6022	A	C	MI.2120	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	119	40	E	A	gAg/gCg	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-3.28	deleterious	-3.6	high_impact	4.37	0.52	damaging	0.46	neutral	3.66	23.20	deleterious	0.2	0.55	0.58	disease	0.75	disease	0.61	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.94	high_impact	0.62	0.9	2.34	6.73	0.57	P	0.71	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13250	13250	C	G	MI.21200	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	914	305	S	C	tCc/tGc	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	2.49	deleterious	-6.66	deleterious	-4.51	high_impact	4.85	0.34	damaging	0.13	damaging	3.59	23.20	deleterious	0.17	0.45	0.97	disease	0.82	disease	0.74	disease	0.82	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.12	medium_impact	3.23	high_impact	0.61	0.8	28.52	7.39	0.76	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13250	13250	C	A	MI.21201	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	914	305	S	Y	tCc/tAc	7.3	1	0	probably_damaging	1	neutral	1	neutral	2.44	deleterious	-10.34	deleterious	-5.41	high_impact	5.2	0.35	damaging	0.13	damaging	4.11	23.80	deleterious	0.14	0.4	0.95	disease	0.88	disease	0.78	disease	0.85	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.90	deleterious	-3.6	low_impact	1.89	high_impact	3.55	high_impact	0.63	0.8	28.52	7.39	0.68	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13252	13252	A	C	MI.21202	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	916	306	T	P	Act/Cct	-20	0	0	probably_damaging	1	neutral	0.21	neutral	4.05	deleterious	-5.63	deleterious	-5.41	high_impact	4.54	0.48	damaging	0.14	damaging	3.50	23.10	deleterious	0.18	0.45	0.73	disease	0.83	disease	0.85	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.09	medium_impact	2.94	high_impact	0.58	0.8	25.7	7.43	0.48	N	0.97	disease_causing	0.61	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13252	13252	A	G	MI.21203	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	916	306	T	A	Act/Gct	-20	0	0	probably_damaging	1	neutral	0.54	neutral	4.11	deleterious	-3.34	deleterious	-4.51	high_impact	4.68	0.48	damaging	0.13	damaging	3.50	23.10	deleterious	0.32	0.5	0.68	disease	0.64	disease	0.74	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.27	medium_impact	3.07	high_impact	0.70	0.85	25.7	7.43	0.5	N	0.69	polymorphism	0.77	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13252	13252	A	T	MI.21204	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	916	306	T	S	Act/Tct	-20	0	0	probably_damaging	1	neutral	0.46	neutral	4.78	neutral	0.37	deleterious	-3.6	high_impact	4.88	0.51	damaging	0.14	damaging	3.36	22.90	deleterious	0.3	0.45	0.48	neutral	0.75	disease	0.7	disease	0.71	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.19	medium_impact	3.26	high_impact	0.63	0.8	25.7	7.43	0.6	P	0.89	polymorphism	0.91	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13253	13253	C	T	MI.21205	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	917	306	T	I	aCt/aTt	8.44	1	0	probably_damaging	1	neutral	0.41	neutral	4.04	deleterious	-6.36	deleterious	-5.41	high_impact	4.88	0.44	damaging	0.12	damaging	3.92	23.50	deleterious	0.29	0.45	0.9	disease	0.88	disease	0.74	disease	0.8	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.15	medium_impact	3.26	high_impact	0.66	0.8	25.7	7.43	0.75	P	0.95	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13253	13253	C	A	MI.21206	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	917	306	T	N	aCt/aAt	8.44	1	0	probably_damaging	1	neutral	0.32	neutral	4.05	deleterious	-5.39	deleterious	-4.51	high_impact	5.24	0.41	damaging	0.11	damaging	3.67	23.30	deleterious	0.3	0.45	0.95	disease	0.81	disease	0.78	disease	0.85	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.05	medium_impact	3.58	high_impact	0.72	0.85	25.7	7.43	0.78	P	0.93	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13253	13253	C	G	MI.21207	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	917	306	T	S	aCt/aGt	8.44	1	0	probably_damaging	1	neutral	0.46	neutral	4.78	neutral	0.37	deleterious	-3.6	high_impact	4.88	0.51	damaging	0.14	damaging	3.56	23.10	deleterious	0.3	0.45	0.48	neutral	0.75	disease	0.7	disease	0.71	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.19	medium_impact	3.26	high_impact	0.63	0.8	25.7	7.43	0.72	P	0.89	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13255	13255	T	A	MI.21208	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	919	307	S	T	Tca/Aca	-7.38	0	0	probably_damaging	1	neutral	0.41	neutral	4.64	neutral	-0.19	deleterious	-2.7	neutral_impact	0.09	0.65	neutral	0.18	damaging	3.82	23.40	deleterious	0.36	0.5	0.77	disease	0.51	disease	0.73	disease	0.6	disease	2	1	deleterious	0.21	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.15	medium_impact	-1.12	low_impact	0.66	0.8	29.52	7.37	0.22	N	0.71	polymorphism	0.89	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13255	13255	T	G	MI.21209	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	919	307	S	A	Tca/Gca	-7.38	0	0	probably_damaging	1	neutral	0.52	neutral	4.65	neutral	1.04	deleterious	-2.7	low_impact	1.23	0.63	neutral	0.18	damaging	3.73	23.30	deleterious	0.39	0.5	0.73	disease	0.57	disease	0.68	disease	0.56	disease	1	1	deleterious	0.26	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.25	medium_impact	-0.08	medium_impact	0.73	0.85	29.52	7.37	0.19	N	0.49	polymorphism	0.96	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6022	6022	A	T	MI.2121	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	119	40	E	V	gAg/gTg	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-4.58	deleterious	-4.22	high_impact	5.06	0.41	damaging	0.39	neutral	4.20	23.90	deleterious	0.2	0.55	0.75	disease	0.86	disease	0.63	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.57	high_impact	0.59	0.9	2.34	6.73	0.82	P	0.67	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13255	13255	T	C	MI.21210	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	919	307	S	P	Tca/Cca	-7.38	0	0	probably_damaging	1	neutral	0.2	neutral	4.61	neutral	-2.57	deleterious	-4.51	medium_impact	3.48	0.66	neutral	0.16	damaging	3.98	23.60	deleterious	0.21	0.45	0.92	disease	0.88	disease	0.82	disease	0.86	disease	7	1	deleterious	0.1	neutral	1	deleterious	0.91	deleterious	-3.6	low_impact	-0.1	medium_impact	1.98	medium_impact	0.72	0.85	29.52	7.37	0.34	N	0.98	polymorphism	0.57	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13256	13256	C	G	MI.21211	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	920	307	S	W	tCa/tGa	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	4.61	deleterious	-3.29	deleterious	-6.31	medium_impact	3.48	0.7	neutral	0.14	damaging	4.37	24.10	deleterious	0.14	0.4	0.94	disease	0.9	disease	0.77	disease	0.85	disease	7	1	deleterious	0.1	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	-0.12	medium_impact	1.98	medium_impact	0.50	0.8	29.52	7.37	0.53	P	0.99	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13256	13256	C	T	MI.21212	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	920	307	S	L	tCa/tTa	7.3	1	0	probably_damaging	1	neutral	0.67	neutral	4.83	neutral	1.48	deleterious	-5.41	neutral_impact	0.17	0.66	neutral	0.16	damaging	4.61	24.40	deleterious	0.3	0.45	0.42	neutral	0.82	disease	0.72	disease	0.59	disease	2	1	deleterious	0.34	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.4	medium_impact	-1.05	low_impact	0.75	0.85	29.52	7.37	0.41	N	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13258	13258	A	C	MI.21213	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	922	308	S	R	Agt/Cgt	-5.78	0	0	probably_damaging	1	neutral	0.35	neutral	4.34	deleterious	-4.86	deleterious	-4.51	high_impact	5.21	0.38	damaging	0.13	damaging	3.87	23.50	deleterious	0.19	0.45	0.87	disease	0.88	disease	0.76	disease	0.81	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.08	medium_impact	3.56	high_impact	0.68	0.85	27.86	7.43	0.68	P	0.99	polymorphism	0.81	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13258	13258	A	G	MI.21214	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	922	308	S	G	Agt/Ggt	-5.78	0	0	probably_damaging	1	neutral	0.35	neutral	4.42	deleterious	-3.41	deleterious	-3.61	high_impact	4.05	0.27	damaging	0.17	damaging	3.59	23.20	deleterious	0.34	0.5	0.69	disease	0.73	disease	0.7	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.08	medium_impact	2.5	high_impact	0.62	0.8	27.86	7.43	0.81	P	0.86	polymorphism	0.96	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13258	13258	A	T	MI.21215	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	922	308	S	C	Agt/Tgt	-5.78	0	0	probably_damaging	1	neutral	0.18	neutral	4.33	deleterious	-6.91	deleterious	-4.51	high_impact	4.86	0.36	damaging	0.13	damaging	3.47	23.00	deleterious	0.23	0.45	0.97	disease	0.8	disease	0.67	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.13	medium_impact	3.24	high_impact	0.49	0.8	27.86	7.43	0.61	P	0.99	polymorphism	0.84	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13259	13259	G	C	MI.21216	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	923	308	S	T	aGt/aCt	6.84	1	0	probably_damaging	1	neutral	0.4	neutral	4.4	deleterious	-4.38	deleterious	-2.7	high_impact	4.17	0.37	damaging	0.13	damaging	3.42	23.00	deleterious	0.25	0.45	0.78	disease	0.69	disease	0.7	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.14	medium_impact	2.61	high_impact	0.74	0.85	27.86	7.43	0.72	P	0.71	disease_causing	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13259	13259	G	T	MI.21217	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	923	308	S	I	aGt/aTt	6.84	1	0	probably_damaging	1	neutral	0.4	neutral	4.35	deleterious	-6.04	deleterious	-5.41	high_impact	5.21	0.33	damaging	0.13	damaging	4.11	23.70	deleterious	0.21	0.45	0.87	disease	0.91	disease	0.71	disease	0.8	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.14	medium_impact	3.56	high_impact	0.71	0.85	27.86	7.43	0.76	P	0.99	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13259	13259	G	A	MI.21218	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	923	308	S	N	aGt/aAt	6.84	1	0	probably_damaging	1	neutral	0.31	neutral	4.36	deleterious	-4.46	deleterious	-2.7	high_impact	5.21	0.27	damaging	0.13	damaging	3.64	23.20	deleterious	0.46	0.55	0.83	disease	0.76	disease	0.69	disease	0.72	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.04	medium_impact	3.56	high_impact	0.55	0.8	27.86	7.43	0.89	P	0.87	disease_causing	0.99	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13261	13261	C	A	MI.21219	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	925	309	Q	K	Caa/Aaa	-3.03	0	0	probably_damaging	1	neutral	0.32	neutral	4.36	deleterious	-3.87	deleterious	-3.6	high_impact	5.17	0.44	damaging	0.14	damaging	3.94	23.50	deleterious	0.37	0.5	0.81	disease	0.88	disease	0.78	disease	0.78	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.05	medium_impact	3.52	high_impact	0.74	0.85	28.19	7.36	0.74	P	0.96	disease_causing	0.82	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6022	6022	A	G	MI.2122	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	119	40	E	G	gAg/gGg	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-3.93	deleterious	-4.22	high_impact	4.71	0.35	damaging	0.56	neutral	4.20	23.90	deleterious	0.28	0.55	0.68	disease	0.74	disease	0.64	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.25	high_impact	0.56	0.9	2.34	6.73	0.84	P	0.67	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13261	13261	C	G	MI.21220	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	925	309	Q	E	Caa/Gaa	-3.03	0	0	probably_damaging	1	neutral	0.28	neutral	4.4	deleterious	-3.65	deleterious	-2.7	high_impact	4.82	0.49	damaging	0.13	damaging	3.10	22.50	deleterious	0.37	0.5	0.78	disease	0.8	disease	0.78	disease	0.75	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.01	medium_impact	3.2	high_impact	0.60	0.8	28.19	7.36	0.73	P	0.92	disease_causing	0.68	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13262	13262	A	C	MI.21221	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	926	309	Q	P	cAa/cCa	7.07	1	0	probably_damaging	1	neutral	0.2	neutral	4.3	deleterious	-6.06	deleterious	-5.41	high_impact	5.17	0.46	damaging	0.13	damaging	3.38	22.90	deleterious	0.3	0.45	0.94	disease	0.89	disease	0.81	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.1	medium_impact	3.52	high_impact	0.63	0.8	28.19	7.36	0.73	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13262	13262	A	G	MI.21222	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	926	309	Q	R	cAa/cGa	7.07	1	0	probably_damaging	1	neutral	0.36	neutral	4.33	deleterious	-4.57	deleterious	-3.6	high_impact	4.82	0.51	damaging	0.11	damaging	3.50	23.10	deleterious	0.36	0.5	0.86	disease	0.89	disease	0.77	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.1	medium_impact	3.2	high_impact	0.60	0.8	28.19	7.36	0.74	P	0.85	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13262	13262	A	T	MI.21223	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	926	309	Q	L	cAa/cTa	7.07	1	0	probably_damaging	1	neutral	0.77	neutral	4.31	deleterious	-5.47	deleterious	-6.31	high_impact	5.17	0.4	damaging	0.12	damaging	3.84	23.40	deleterious	0.22	0.45	0.74	disease	0.88	disease	0.7	disease	0.72	disease	4	1	deleterious	0.39	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.52	medium_impact	3.52	high_impact	0.46	0.8	28.19	7.36	0.76	P	0.96	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13263	13263	A	T	MI.21224	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	927	309	Q	H	caA/caT	8.44	1	0.03	probably_damaging	1	neutral	0.55	neutral	4.75	neutral	-0.96	deleterious	-4.5	medium_impact	3.02	0.4	damaging	0.15	damaging	3.56	23.10	deleterious	0.48	0.55	0.55	disease	0.83	disease	0.79	disease	0.74	disease	5	1	deleterious	0.28	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.28	medium_impact	1.56	medium_impact	0.77	0.85	28.19	7.36	0.73	P	0.94	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13263	13263	A	C	MI.21225	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	927	309	Q	H	caA/caC	8.44	1	0.03	probably_damaging	1	neutral	0.55	neutral	4.75	neutral	-0.96	deleterious	-4.5	medium_impact	3.02	0.4	damaging	0.15	damaging	3.42	23.00	deleterious	0.48	0.55	0.55	disease	0.83	disease	0.79	disease	0.74	disease	5	1	deleterious	0.28	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.28	medium_impact	1.56	medium_impact	0.77	0.85	28.19	7.36	0.71	P	0.94	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13264	13264	C	A	MI.21226	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	928	310	L	M	Cta/Ata	0.64	0.35	0	probably_damaging	1	neutral	0.28	neutral	4.66	neutral	-0.96	neutral	-1.8	high_impact	3.55	0.37	damaging	0.17	damaging	3.94	23.50	deleterious	0.34	0.5	0.59	disease	0.7	disease	0.62	disease	0.66	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.01	medium_impact	2.04	high_impact	0.79	0.85	26.53	7.36	0.59	P	0.89	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13264	13264	C	G	MI.21227	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	928	310	L	V	Cta/Gta	0.64	0.35	0	probably_damaging	1	neutral	0.5	neutral	4.44	neutral	-1.98	deleterious	-2.7	high_impact	3.94	0.24	damaging	0.14	damaging	3.42	23.00	deleterious	0.45	0.55	0.74	disease	0.76	disease	0.71	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.23	medium_impact	2.4	high_impact	0.62	0.8	26.53	7.36	0.86	P	0.81	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13265	13265	T	G	MI.21228	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	929	310	L	R	cTa/cGa	-0.04	0.29	0	probably_damaging	1	neutral	0.36	neutral	4.3	deleterious	-5.78	deleterious	-5.41	high_impact	5.17	0.36	damaging	0.13	damaging	4.26	23.90	deleterious	0.18	0.45	0.95	disease	0.92	disease	0.81	disease	0.84	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.1	medium_impact	3.52	high_impact	0.54	0.8	26.53	7.36	0.72	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13265	13265	T	C	MI.21229	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	929	310	L	P	cTa/cCa	-0.04	0.29	0	probably_damaging	1	neutral	0.2	neutral	4.3	deleterious	-6.22	deleterious	-6.31	high_impact	4.83	0.29	damaging	0.14	damaging	4.01	23.60	deleterious	0.18	0.45	0.96	disease	0.85	disease	0.8	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.1	medium_impact	3.21	high_impact	0.62	0.8	26.53	7.36	0.83	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6023	6023	G	C	MI.2123	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	120	40	E	D	gaG/gaC	8.69	1	0.07	probably_damaging	0.99	deleterious	0	neutral	2.64	neutral	-2.54	neutral	-1.82	high_impact	3.86	0.45	damaging	0.43	neutral	3.52	23.10	deleterious	0.42	0.55	0.52	disease	0.76	disease	0.57	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	2.47	high_impact	0.80	0.9	2.34	6.73	0.64	P	0.69	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13265	13265	T	A	MI.21230	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	929	310	L	Q	cTa/cAa	-0.04	0.29	0	probably_damaging	1	neutral	0.37	neutral	4.3	deleterious	-5.96	deleterious	-5.41	high_impact	5.17	0.33	damaging	0.13	damaging	4.42	24.20	deleterious	0.22	0.45	0.95	disease	0.85	disease	0.71	disease	0.83	disease	7	1	deleterious	0.19	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.11	medium_impact	3.52	high_impact	0.66	0.8	26.53	7.36	0.66	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13267	13267	G	C	MI.21231	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	931	311	G	R	Gga/Cga	-3.03	0	0	probably_damaging	1	neutral	0.38	neutral	3.39	deleterious	-11.38	deleterious	-7.21	high_impact	5.2	0.44	damaging	0.09	damaging	3.92	23.50	deleterious	0.06	0.35	0.97	disease	0.92	disease	0.82	disease	0.82	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	0.12	medium_impact	3.55	high_impact	0.66	0.8	28.86	7.38	0.51	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13267	13267	G	T	MI.21232	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	931	311	G	W	Gga/Tga	-3.03	0	0	probably_damaging	1	neutral	0.18	neutral	3.38	deleterious	-12.85	deleterious	-7.21	high_impact	5.2	0.43	damaging	0.09	damaging	4.43	24.20	deleterious	0.1	0.4	0.99	disease	0.91	disease	0.78	disease	0.88	disease	8	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.13	medium_impact	3.55	high_impact	0.39	0.8	28.86	7.38	0.47	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13268	13268	G	A	MI.21233	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	932	311	G	E	gGa/gAa	8.9	1	0	probably_damaging	1	neutral	0.31	neutral	3.4	deleterious	-11.6	deleterious	-7.21	high_impact	5.2	0.39	damaging	0.09	damaging	3.94	23.50	deleterious	0.09	0.35	0.96	disease	0.91	disease	0.82	disease	0.85	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.04	medium_impact	3.55	high_impact	0.65	0.8	28.86	7.38	0.67	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	COSM488746	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13268	13268	G	C	MI.21234	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	932	311	G	A	gGa/gCa	8.9	1	0	probably_damaging	1	neutral	0.56	neutral	3.48	deleterious	-6.91	deleterious	-5.4	high_impact	3.6	0.36	damaging	0.15	damaging	3.09	22.50	deleterious	0.17	0.45	0.86	disease	0.76	disease	0.7	disease	0.76	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.29	medium_impact	2.09	high_impact	0.61	0.8	28.86	7.38	0.69	P	0.79	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13268	13268	G	T	MI.21235	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	932	311	G	V	gGa/gTa	8.9	1	0	probably_damaging	1	neutral	0.54	neutral	3.4	deleterious	-10.23	deleterious	-8.11	high_impact	5.2	0.33	damaging	0.09	damaging	3.79	23.40	deleterious	0.09	0.35	0.94	disease	0.91	disease	0.75	disease	0.84	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.27	medium_impact	3.55	high_impact	0.63	0.8	28.86	7.38	0.62	P	0.98	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13270	13270	C	T	MI.21236	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	934	312	L	F	Ctc/Ttc	-5.55	0	0	benign	0.38	neutral	0.72	neutral	4.72	neutral	0.08	deleterious	-3.6	low_impact	1.41	0.51	damaging	0.41	neutral	4.03	23.70	deleterious	0.39	0.5	0.37	neutral	0.79	disease	0.61	disease	0.62	disease	2	0.28	neutral	0.67	deleterious	-6	neutral	0.76	deleterious	-0.54	medium_impact	0.46	medium_impact	0.09	medium_impact	0.63	0.8	28.52	7.24	0.33	N	0.99	disease_causing	0.5	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13270	13270	C	A	MI.21237	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	934	312	L	I	Ctc/Atc	-5.55	0	0	possibly_damaging	0.9	neutral	0.4	neutral	4.54	neutral	-1.17	neutral	-1.8	medium_impact	2.9	0.51	damaging	0.48	neutral	4.13	23.80	deleterious	0.38	0.5	0.61	disease	0.77	disease	0.67	disease	0.68	disease	4	0.9	neutral	0.25	neutral	0	NA	0.80	deleterious	-1.65	low_impact	0.14	medium_impact	1.45	medium_impact	0.79	0.85	28.52	7.24	0.35	N	0.85	polymorphism	0.9	0.03	.	.	.	.	.	.	COSM488747	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13270	13270	C	G	MI.21238	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	934	312	L	V	Ctc/Gtc	-5.55	0	0	possibly_damaging	0.9	neutral	0.54	neutral	4.53	neutral	-1.84	deleterious	-2.7	medium_impact	2.65	0.52	damaging	0.34	neutral	3.46	23.00	deleterious	0.39	0.5	0.69	disease	0.73	disease	0.68	disease	0.66	disease	3	0.88	neutral	0.32	neutral	0	NA	0.80	deleterious	-1.65	low_impact	0.27	medium_impact	1.22	medium_impact	0.76	0.85	28.52	7.24	0.26	N	0.81	polymorphism	0.83	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13271	13271	T	C	MI.21239	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	935	312	L	P	cTc/cCc	0.18	0.02	0	probably_damaging	1	neutral	0.2	neutral	4.43	deleterious	-5.28	deleterious	-6.31	high_impact	4.64	0.44	damaging	0.34	neutral	4.00	23.60	deleterious	0.11	0.4	0.95	disease	0.88	disease	0.77	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.1	medium_impact	3.04	high_impact	0.75	0.85	28.52	7.24	0.72	P	0.99	polymorphism	0.66	0.32	.	.	.	.	.	.	.	.	.	T13271C	Exercise intolerance (EXIT)	-	+	Reported	2	.	P	P	damaging
chrM	6023	6023	G	T	MI.2124	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	120	40	E	D	gaG/gaT	8.69	1	0.07	probably_damaging	0.99	deleterious	0	neutral	2.64	neutral	-2.54	neutral	-1.82	high_impact	3.86	0.45	damaging	0.43	neutral	3.68	23.30	deleterious	0.42	0.55	0.52	disease	0.76	disease	0.57	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	2.47	high_impact	0.80	0.9	2.34	6.73	0.64	P	0.69	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13271	13271	T	A	MI.21240	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	935	312	L	H	cTc/cAc	0.18	0.02	0	probably_damaging	1	neutral	0.53	neutral	4.43	deleterious	-5.24	deleterious	-6.31	high_impact	4.64	0.53	damaging	0.3	neutral	4.31	24.00	deleterious	0.13	0.4	0.95	disease	0.87	disease	0.74	disease	0.83	disease	7	0.99	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.26	medium_impact	3.04	high_impact	0.68	0.85	28.52	7.24	0.5	N	0.97	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13271	13271	T	G	MI.21241	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	935	312	L	R	cTc/cGc	0.18	0.02	0	probably_damaging	0.99	neutral	0.34	neutral	4.43	deleterious	-4.69	deleterious	-5.41	high_impact	4.64	0.51	damaging	0.3	neutral	4.24	23.90	deleterious	0.1	0.4	0.93	disease	0.92	disease	0.77	disease	0.85	disease	7	0.99	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-2.64	low_impact	0.07	medium_impact	3.04	high_impact	0.61	0.8	28.52	7.24	0.59	P	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13273	13273	A	T	MI.21242	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	937	313	M	L	Ata/Tta	-6.7	0	0	probably_damaging	0.98	neutral	0.72	neutral	4.69	neutral	-1.75	deleterious	-2.7	medium_impact	2.9	0.37	damaging	0.07	damaging	3.44	23.00	deleterious	0.28	0.45	0.5	disease	0.76	disease	0.7	disease	0.69	disease	4	0.98	deleterious	0.37	neutral	1	deleterious	0.68	deleterious	-2.35	low_impact	0.46	medium_impact	1.45	medium_impact	0.51	0.8	28.03	7.14	0.42	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13273	13273	A	G	MI.21243	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	937	313	M	V	Ata/Gta	-6.7	0	0	probably_damaging	0.99	neutral	0.53	neutral	4.48	neutral	-1.06	deleterious	-3.6	high_impact	4.13	0.36	damaging	0.08	damaging	2.83	21.50	deleterious	0.37	0.5	0.51	disease	0.82	disease	0.7	disease	0.72	disease	4	0.99	deleterious	0.27	neutral	2	deleterious	0.72	deleterious	-2.64	low_impact	0.26	medium_impact	2.57	high_impact	0.57	0.8	28.03	7.14	0.43	N	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13273	13273	A	C	MI.21244	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	937	313	M	L	Ata/Cta	-6.7	0	0	probably_damaging	0.98	neutral	0.72	neutral	4.69	neutral	-1.75	deleterious	-2.7	medium_impact	2.9	0.37	damaging	0.07	damaging	3.34	22.90	deleterious	0.28	0.45	0.5	disease	0.76	disease	0.7	disease	0.69	disease	4	0.98	deleterious	0.37	neutral	1	deleterious	0.68	deleterious	-2.35	low_impact	0.46	medium_impact	1.45	medium_impact	0.51	0.8	28.03	7.14	0.42	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13274	13274	T	C	MI.21245	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	938	313	M	T	aTa/aCa	8.44	1	0	probably_damaging	1	neutral	0.42	neutral	4.45	deleterious	-4.36	deleterious	-5.41	high_impact	5.1	0.45	damaging	0.1	damaging	2.99	22.20	deleterious	0.23	0.45	0.76	disease	0.86	disease	0.72	disease	0.73	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.16	medium_impact	3.46	high_impact	0.32	0.8	28.03	7.14	0.69	P	0.99	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13274	13274	T	A	MI.21246	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	938	313	M	K	aTa/aAa	8.44	1	0	probably_damaging	1	neutral	0.29	neutral	4.39	deleterious	-5.88	deleterious	-5.41	high_impact	5.1	0.46	damaging	0.09	damaging	4.00	23.60	deleterious	0.1	0.4	0.93	disease	0.89	disease	0.79	disease	0.85	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.02	medium_impact	3.46	high_impact	0.42	0.8	28.03	7.14	0.73	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13275	13275	A	T	MI.21247	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	939	313	M	I	atA/atT	7.3	1	0	probably_damaging	0.99	neutral	0.47	neutral	4.54	neutral	-0.42	deleterious	-3.6	medium_impact	2.77	0.43	damaging	0.13	damaging	3.51	23.10	deleterious	0.38	0.5	0.46	neutral	0.83	disease	0.72	disease	0.73	disease	5	0.99	deleterious	0.24	neutral	1	deleterious	0.77	deleterious	-2.64	low_impact	0.2	medium_impact	1.33	medium_impact	0.68	0.85	28.03	7.14	0.69	P	0.94	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13275	13275	A	C	MI.21248	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	939	313	M	I	atA/atC	7.3	1	0	probably_damaging	0.99	neutral	0.47	neutral	4.54	neutral	-0.42	deleterious	-3.6	medium_impact	2.77	0.43	damaging	0.13	damaging	3.45	23.00	deleterious	0.38	0.5	0.46	neutral	0.83	disease	0.72	disease	0.73	disease	5	0.99	deleterious	0.24	neutral	1	deleterious	0.77	deleterious	-2.64	low_impact	0.2	medium_impact	1.33	medium_impact	0.68	0.85	28.03	7.14	0.68	P	0.94	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13276	13276	A	G	MI.21249	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	940	314	M	V	Ata/Gta	2.48	1	0	benign	0.01	neutral	0.54	neutral	4.57	neutral	0.2	deleterious	-3.07	low_impact	1.16	0.88	neutral	0.71	neutral	0.90	10.06	neutral	0.46	0.55	0.57	disease	0.68	disease	0.64	disease	0.51	disease	0	0.44	neutral	0.77	deleterious	-6	neutral	0.22	neutral	1.15	medium_impact	0.27	medium_impact	-0.14	medium_impact	0.74	0.85	7.3	13.65	0.37	N	0.95	disease_causing	0.96	0.08	rs2853502	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6024	6024	C	G	MI.2125	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	121	41	L	V	Ctg/Gtg	0.59	0.05	0	probably_damaging	0.98	deleterious	0	neutral	2.37	deleterious	-5.01	neutral	-1.81	high_impact	5.13	0.44	damaging	0.08	damaging	3.23	22.80	deleterious	0.35	0.55	0.72	disease	0.67	disease	0.64	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	3.64	high_impact	0.75	0.9	2.53	7	0.61	P	0.66	disease_causing	0.57	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13276	13276	A	C	MI.21250	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	940	314	M	L	Ata/Cta	2.48	1	0	benign	0.12	neutral	0.74	neutral	4.65	neutral	1.02	neutral	-2.34	medium_impact	3.04	0.66	neutral	0.56	neutral	1.48	13.19	neutral	0.44	0.55	0.41	neutral	0.72	disease	0.62	disease	0.6	disease	2	0.15	neutral	0.81	deleterious	-3	neutral	0.23	neutral	0.08	medium_impact	0.48	medium_impact	1.57	medium_impact	0.70	0.85	7.3	13.65	0.39	N	0.98	disease_causing	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13276	13276	A	T	MI.21251	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	940	314	M	L	Ata/Tta	2.48	1	0	benign	0.12	neutral	0.74	neutral	4.65	neutral	1.02	neutral	-2.34	medium_impact	3.04	0.66	neutral	0.56	neutral	1.55	13.56	neutral	0.44	0.55	0.41	neutral	0.72	disease	0.62	disease	0.6	disease	2	0.15	neutral	0.81	deleterious	-3	neutral	0.23	neutral	0.08	medium_impact	0.48	medium_impact	1.57	medium_impact	0.70	0.85	7.3	13.65	0.4	N	0.98	disease_causing	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13277	13277	T	C	MI.21252	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	941	314	M	T	aTa/aCa	5.46	1	0	benign	0.04	neutral	0.43	neutral	4.47	neutral	-0.75	deleterious	-4.67	medium_impact	2.08	0.71	neutral	0.57	neutral	1.23	11.89	neutral	0.35	0.5	0.74	disease	0.82	disease	0.64	disease	0.59	disease	2	0.53	neutral	0.7	deleterious	-3	neutral	0.45	deleterious	0.57	medium_impact	0.17	medium_impact	0.7	medium_impact	0.48	0.8	7.3	13.65	0.48	N	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13277	13277	T	A	MI.21253	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	941	314	M	K	aTa/aAa	5.46	1	0	possibly_damaging	0.64	neutral	0.33	neutral	4.42	deleterious	-4.16	deleterious	-5.01	high_impact	4.61	0.63	neutral	0.36	neutral	2.67	20.60	deleterious	0.11	0.4	0.91	disease	0.88	disease	0.75	disease	0.82	disease	6	0.71	neutral	0.35	neutral	1	deleterious	0.58	deleterious	-0.98	medium_impact	0.06	medium_impact	3.01	high_impact	0.55	0.8	7.3	13.65	0.63	P	1.00	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13278	13278	A	C	MI.21254	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	942	314	M	I	atA/atC	7.3	1	0.02	benign	0.25	neutral	0.52	neutral	4.64	neutral	-0.11	deleterious	-3.04	low_impact	1.84	0.78	neutral	0.95	neutral	0.39	6.56	deleterious	0.39	0.5	0.54	disease	0.76	disease	0.62	disease	0.55	disease	1	0.38	neutral	0.64	deleterious	-6	neutral	0.27	neutral	-0.29	medium_impact	0.25	medium_impact	0.48	medium_impact	0.81	0.85	7.3	13.65	0.5	N	0.94	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13278	13278	A	T	MI.21255	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	942	314	M	I	atA/atT	7.3	1	0.02	benign	0.25	neutral	0.52	neutral	4.64	neutral	-0.11	deleterious	-3.04	low_impact	1.84	0.78	neutral	0.95	neutral	0.63	8.36	deleterious	0.39	0.5	0.54	disease	0.76	disease	0.62	disease	0.55	disease	1	0.38	neutral	0.64	deleterious	-6	neutral	0.27	neutral	-0.29	medium_impact	0.25	medium_impact	0.48	medium_impact	0.81	0.85	7.3	13.65	0.5	N	0.94	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13279	13279	G	T	MI.21256	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	943	315	V	F	Gtt/Ttt	0.64	0.99	0	probably_damaging	0.94	neutral	0.7	neutral	4.57	neutral	-1.49	deleterious	-4.43	low_impact	1.27	0.67	neutral	0.42	neutral	3.78	23.40	deleterious	0.29	0.45	0.65	disease	0.85	disease	0.62	disease	0.56	disease	1	0.93	neutral	0.38	neutral	-2	neutral	0.77	deleterious	-1.88	low_impact	0.44	medium_impact	-0.04	medium_impact	0.73	0.85	5.97	7.55	0.26	N	0.96	disease_causing	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13279	13279	G	A	MI.21257	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	943	315	V	I	Gtt/Att	0.64	0.99	0	benign	0.12	neutral	0.4	neutral	4.65	neutral	-0.32	neutral	-0.9	medium_impact	2.15	0.67	neutral	0.55	neutral	3.29	22.80	deleterious	0.4	0.5	0.52	disease	0.62	disease	0.49	neutral	0.46	neutral	1	0.53	neutral	0.64	deleterious	-3	neutral	0.52	deleterious	0.08	medium_impact	0.14	medium_impact	0.76	medium_impact	0.79	0.85	5.97	7.55	0.43	N	0.11	disease_causing	0.63	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13279	13279	G	C	MI.21258	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	943	315	V	L	Gtt/Ctt	0.64	0.99	0	possibly_damaging	0.52	neutral	0.65	neutral	4.67	neutral	0.93	deleterious	-2.65	low_impact	1.22	0.68	neutral	0.62	neutral	1.96	15.97	deleterious	0.35	0.5	0.34	neutral	0.71	disease	0.53	disease	0.51	disease	0	0.43	neutral	0.57	deleterious	-3	neutral	0.45	deleterious	-0.78	medium_impact	0.38	medium_impact	-0.09	medium_impact	0.69	0.85	5.97	7.55	0.3	N	0.69	disease_causing	0.85	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13280	13280	T	C	MI.21259	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	944	315	V	A	gTt/gCt	5	1	0	benign	0.12	neutral	0.51	neutral	4.65	neutral	-0.61	deleterious	-3.49	low_impact	1.28	0.7	neutral	0.59	neutral	1.66	14.20	neutral	0.34	0.5	0.69	disease	0.63	disease	0.53	disease	0.52	disease	0	0.4	neutral	0.7	deleterious	-6	neutral	0.24	neutral	0.08	medium_impact	0.24	medium_impact	-0.03	medium_impact	0.38	0.8	5.97	7.55	0.45	N	0.75	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6024	6024	C	A	MI.2126	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	121	41	L	M	Ctg/Atg	0.59	0.05	0	probably_damaging	1	neutral	0.06	neutral	2.32	deleterious	-5.74	neutral	-1.22	high_impact	3.75	0.54	damaging	0.14	damaging	3.65	23.20	deleterious	0.3	0.55	0.77	disease	0.69	disease	0.54	disease	0.58	disease	2	1	deleterious	0.03	neutral	2	deleterious	0.81	deleterious	-3.58	low_impact	-0.47	medium_impact	2.36	high_impact	0.82	0.9	2.53	7	0.38	N	0.59	disease_causing	0.51	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13280	13280	T	A	MI.21260	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	944	315	V	D	gTt/gAt	5	1	0	probably_damaging	0.96	neutral	0.21	neutral	4.49	deleterious	-5.77	deleterious	-6.16	high_impact	4.08	0.7	neutral	0.4	neutral	4.47	24.20	deleterious	0.09	0.4	0.96	disease	0.89	disease	0.71	disease	0.83	disease	7	0.97	neutral	0.13	neutral	2	deleterious	0.80	deleterious	-2.06	low_impact	-0.09	medium_impact	2.52	high_impact	0.59	0.8	5.97	7.55	0.51	N	0.97	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13280	13280	T	G	MI.21261	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	944	315	V	G	gTt/gGt	5	1	0	possibly_damaging	0.83	neutral	0.33	neutral	4.67	deleterious	-3.52	deleterious	-6.17	medium_impact	2.84	0.66	neutral	0.5	neutral	2.25	17.87	deleterious	0.14	0.4	0.76	disease	0.79	disease	0.61	disease	0.67	disease	3	0.85	neutral	0.25	neutral	0	NA	0.58	deleterious	-1.4	low_impact	0.06	medium_impact	1.39	medium_impact	0.56	0.8	5.97	7.55	0.47	N	0.91	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13282	13282	A	T	MI.21262	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	946	316	T	S	Aca/Tca	-14.04	0	0	probably_damaging	1	neutral	0.46	neutral	4.65	neutral	-0.5	deleterious	-3.6	neutral_impact	0.38	0.58	damaging	0.11	damaging	3.28	22.80	deleterious	0.57	0.65	0.63	disease	0.59	disease	0.51	disease	0.49	neutral	0	1	deleterious	0.23	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.19	medium_impact	-0.86	medium_impact	0.69	0.85	14.59	7.01	0.23	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13282	13282	A	G	MI.21263	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	946	316	T	A	Aca/Gca	-14.04	0	0	probably_damaging	1	neutral	0.56	neutral	4.73	neutral	2.53	deleterious	-4.51	neutral_impact	-0.66	0.54	damaging	0.25	damaging	3.43	23.00	deleterious	0.57	0.65	0.36	neutral	0.25	neutral	0.46	neutral	0.43	neutral	1	1	deleterious	0.28	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.29	medium_impact	-1.81	low_impact	0.49	0.8	14.59	7.01	0.32	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13282	13282	A	C	MI.21264	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	946	316	T	P	Aca/Cca	-14.04	0	0	probably_damaging	1	neutral	0.2	neutral	4.57	neutral	-1.85	deleterious	-5.41	high_impact	3.62	0.5	damaging	0.05	damaging	3.51	23.10	deleterious	0.16	0.45	0.81	disease	0.85	disease	0.73	disease	0.77	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.1	medium_impact	2.1	high_impact	0.62	0.8	14.59	7.01	0.29	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13283	13283	C	T	MI.21265	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	947	316	T	M	aCa/aTa	1.33	0.43	0	probably_damaging	1	neutral	0.32	neutral	4.64	neutral	-1.16	deleterious	-5.41	low_impact	1.47	0.6	damaging	0.08	damaging	4.00	23.60	deleterious	0.25	0.45	0.66	disease	0.69	disease	0.63	disease	0.56	disease	1	1	deleterious	0.16	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.05	medium_impact	0.14	medium_impact	0.77	0.85	14.59	7.01	0.21	N	0.93	disease_causing	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13283	13283	C	A	MI.21266	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	947	316	T	K	aCa/aAa	1.33	0.43	0	probably_damaging	1	neutral	0.31	neutral	4.58	neutral	-2.37	deleterious	-5.41	high_impact	3.62	0.55	damaging	0.04	damaging	4.41	24.10	deleterious	0.17	0.45	0.78	disease	0.86	disease	0.73	disease	0.77	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.04	medium_impact	2.1	high_impact	0.70	0.85	14.59	7.01	0.31	N	1.00	disease_causing	0.97	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13285	13285	A	T	MI.21267	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	949	317	I	F	Atc/Ttc	-12.89	0	0	probably_damaging	0.97	neutral	0.71	neutral	4.55	neutral	-1.4	deleterious	-3.18	medium_impact	2.72	0.72	neutral	0.38	neutral	3.93	23.50	deleterious	0.32	0.5	0.63	disease	0.82	disease	0.68	disease	0.69	disease	4	0.97	neutral	0.37	neutral	1	deleterious	0.80	deleterious	-2.18	low_impact	0.45	medium_impact	1.28	medium_impact	0.86	0.9	13.93	13.22	0.19	N	0.82	polymorphism	0.78	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13285	13285	A	G	MI.21268	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	949	317	I	V	Atc/Gtc	-12.89	0	0	benign	0.18	neutral	0.53	neutral	4.62	neutral	-0.41	neutral	-0.8	low_impact	1.08	0.84	neutral	0.82	neutral	1.95	15.93	deleterious	0.53	0.6	0.53	disease	0.44	neutral	0.46	neutral	0.39	neutral	2	0.36	neutral	0.68	deleterious	-6	neutral	0.67	deleterious	-0.12	medium_impact	0.26	medium_impact	-0.22	medium_impact	0.74	0.85	13.93	13.22	0.29	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13285	13285	A	C	MI.21269	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	949	317	I	L	Atc/Ctc	-12.89	0	0	possibly_damaging	0.73	neutral	0.69	neutral	4.89	neutral	0.9	neutral	-1.01	neutral_impact	0.42	0.78	neutral	0.91	neutral	2.53	19.65	deleterious	0.37	0.5	0.34	neutral	0.53	disease	0.45	neutral	0.43	neutral	1	0.67	neutral	0.48	deleterious	-3	neutral	0.66	deleterious	-1.16	low_impact	0.42	medium_impact	-0.82	medium_impact	0.83	0.85	13.93	13.22	0.25	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6025	6025	T	A	MI.2127	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	122	41	L	Q	cTg/cAg	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.34	deleterious	-7.76	deleterious	-3.68	high_impact	5.13	0.49	damaging	0.08	damaging	3.99	23.60	deleterious	0.16	0.55	0.94	disease	0.87	disease	0.64	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.75	0.9	2.53	7	0.56	P	0.82	polymorphism	0.86	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13286	13286	T	C	MI.21270	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	950	317	I	T	aTc/aCc	1.1	0.46	0	probably_damaging	0.91	neutral	0.45	neutral	4.51	deleterious	-3.14	deleterious	-4	medium_impact	3.36	0.73	neutral	0.4	neutral	3.48	23.10	deleterious	0.42	0.55	0.82	disease	0.78	disease	0.67	disease	0.73	disease	5	0.91	neutral	0.27	neutral	1	deleterious	0.82	deleterious	-1.7	low_impact	0.18	medium_impact	1.87	medium_impact	0.71	0.85	13.93	13.22	0.26	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13286	13286	T	A	MI.21271	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	950	317	I	N	aTc/aAc	1.1	0.46	0	probably_damaging	0.98	neutral	0.36	neutral	4.47	deleterious	-4.89	deleterious	-5.82	high_impact	3.78	0.7	neutral	0.41	neutral	4.55	24.30	deleterious	0.25	0.45	0.93	disease	0.84	disease	0.69	disease	0.81	disease	6	0.99	deleterious	0.19	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	0.1	medium_impact	2.25	high_impact	0.74	0.85	13.93	13.22	0.34	N	0.93	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13286	13286	T	G	MI.21272	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	950	317	I	S	aTc/aGc	1.1	0.46	0	probably_damaging	0.97	neutral	0.48	neutral	4.52	deleterious	-3.63	deleterious	-4.92	high_impact	3.63	0.74	neutral	0.44	neutral	4.31	24.00	deleterious	0.25	0.45	0.85	disease	0.85	disease	0.67	disease	0.77	disease	5	0.97	neutral	0.26	neutral	2	deleterious	0.83	deleterious	-2.18	low_impact	0.21	medium_impact	2.11	high_impact	0.68	0.85	13.93	13.22	0.3	N	0.90	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13287	13287	C	A	MI.21273	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	951	317	I	M	atC/atA	7.3	0.98	0	probably_damaging	0.98	neutral	0.24	neutral	4.55	neutral	-2.58	neutral	-1.97	medium_impact	2.74	0.77	neutral	0.62	neutral	3.83	23.40	deleterious	0.39	0.5	0.79	disease	0.65	disease	0.59	disease	0.62	disease	2	0.98	deleterious	0.13	neutral	1	deleterious	0.76	deleterious	-2.35	low_impact	-0.04	medium_impact	1.3	medium_impact	0.84	0.9	13.93	13.22	0.51	P	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13287	13287	C	G	MI.21274	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	951	317	I	M	atC/atG	7.3	0.98	0	probably_damaging	0.98	neutral	0.24	neutral	4.55	neutral	-2.58	neutral	-1.97	medium_impact	2.74	0.77	neutral	0.62	neutral	3.33	22.90	deleterious	0.39	0.5	0.79	disease	0.65	disease	0.59	disease	0.62	disease	2	0.98	deleterious	0.13	neutral	1	deleterious	0.76	deleterious	-2.35	low_impact	-0.04	medium_impact	1.3	medium_impact	0.84	0.9	13.93	13.22	0.51	P	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13288	13288	G	A	MI.21275	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	952	318	G	S	Ggc/Agc	-5.09	0	0	probably_damaging	1	neutral	0.45	neutral	4.76	deleterious	-3.51	deleterious	-5.41	medium_impact	2.62	0.32	damaging	0.03	damaging	4.17	23.80	deleterious	0.26	0.45	0.49	neutral	0.85	disease	0.72	disease	0.7	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.18	medium_impact	1.19	medium_impact	0.68	0.85	28.36	7.14	0.45	N	1.00	disease_causing	0.55	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13288	13288	G	T	MI.21276	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	952	318	G	C	Ggc/Tgc	-5.09	0	0	probably_damaging	1	neutral	0.18	neutral	4.54	deleterious	-6.55	deleterious	-8.11	high_impact	3.77	0.28	damaging	0.02	damaging	4.11	23.70	deleterious	0.14	0.4	0.91	disease	0.92	disease	0.74	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.13	medium_impact	2.24	high_impact	0.56	0.8	28.36	7.14	0.54	P	0.97	disease_causing	0.84	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13288	13288	G	C	MI.21277	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	952	318	G	R	Ggc/Cgc	-5.09	0	0	probably_damaging	1	neutral	0.38	neutral	4.55	deleterious	-6.24	deleterious	-7.21	high_impact	5.05	0.33	damaging	0.02	damaging	3.89	23.50	deleterious	0.1	0.4	0.91	disease	0.94	disease	0.83	disease	0.87	disease	7	1	deleterious	0.19	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	0.12	medium_impact	3.41	high_impact	0.59	0.8	28.36	7.14	0.56	P	1.00	disease_causing	0.73	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13289	13289	G	C	MI.21278	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	953	318	G	A	gGc/gCc	8.9	1	0	probably_damaging	1	neutral	0.55	neutral	4.66	neutral	-2.13	deleterious	-5.41	medium_impact	3.21	0.36	damaging	0.03	damaging	3.18	22.70	deleterious	0.39	0.5	0.57	disease	0.8	disease	0.69	disease	0.7	disease	4	1	deleterious	0.28	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.28	medium_impact	1.73	medium_impact	0.65	0.8	28.36	7.14	0.62	P	0.79	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13289	13289	G	A	MI.21279	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	953	318	G	D	gGc/gAc	8.9	1	0	probably_damaging	1	neutral	0.24	neutral	4.54	deleterious	-6.56	deleterious	-6.31	high_impact	4.71	0.26	damaging	0.02	damaging	3.82	23.40	deleterious	0.11	0.4	0.95	disease	0.92	disease	0.82	disease	0.84	disease	7	1	deleterious	0.12	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.04	medium_impact	3.1	high_impact	0.35	0.8	28.36	7.14	0.84	P	0.95	disease_causing	1	0.43	rs28683136	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6025	6025	T	C	MI.2128	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	122	41	L	P	cTg/cCg	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.29	deleterious	-8.2	deleterious	-4.29	high_impact	4.79	0.39	damaging	0.07	damaging	3.79	23.40	deleterious	0.18	0.55	0.95	disease	0.87	disease	0.75	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.56	0.9	2.53	7	0.57	P	0.83	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13289	13289	G	T	MI.21280	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	953	318	G	V	gGc/gTc	8.9	1	0	probably_damaging	1	neutral	0.53	neutral	4.58	deleterious	-4.18	deleterious	-8.11	high_impact	4.08	0.3	damaging	0.02	damaging	3.80	23.40	deleterious	0.15	0.4	0.73	disease	0.93	disease	0.73	disease	0.76	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.26	medium_impact	2.52	high_impact	0.48	0.8	28.36	7.14	0.61	P	0.98	disease_causing	1	0.23	rs28683136	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13291	13291	A	T	MI.21281	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	955	319	I	F	Atc/Ttc	-5.55	0	0	probably_damaging	1	neutral	0.71	neutral	4.49	neutral	-1.53	deleterious	-3.44	low_impact	1.56	0.64	neutral	0.11	damaging	3.86	23.50	deleterious	0.49	0.55	0.8	disease	0.73	disease	0.64	disease	0.75	disease	5	1	deleterious	0.36	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	0.45	medium_impact	0.22	medium_impact	0.84	0.9	15.42	14.58	0.15	N	0.82	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13291	13291	A	G	MI.21282	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	955	319	I	V	Atc/Gtc	-5.55	0	0	probably_damaging	1	neutral	0.52	neutral	4.6	neutral	0.73	neutral	-0.86	neutral_impact	0.72	0.76	neutral	0.22	damaging	3.10	22.50	deleterious	0.73	0.75	0.41	neutral	0.36	neutral	0.59	disease	0.49	neutral	0	1	deleterious	0.26	neutral	-2	neutral	0.64	deleterious	-3.6	low_impact	0.25	medium_impact	-0.55	medium_impact	0.65	0.8	15.42	14.58	0.23	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13291	13291	A	C	MI.21283	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	955	319	I	L	Atc/Ctc	-5.55	0	0	probably_damaging	1	neutral	0.7	neutral	4.73	neutral	1.13	neutral	-1.58	neutral_impact	-0.88	0.75	neutral	0.89	neutral	1.10	11.21	neutral	0.4	0.5	0.36	neutral	0.15	neutral	0.25	neutral	0.26	neutral	5	1	deleterious	0.35	neutral	-2	neutral	0.61	deleterious	-3.6	low_impact	0.44	medium_impact	-2.01	low_impact	0.80	0.85	15.42	14.58	0.29	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13292	13292	T	G	MI.21284	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	956	319	I	S	aTc/aGc	1.56	0.78	0	probably_damaging	1	neutral	0.44	neutral	4.48	neutral	-1.61	deleterious	-5.21	medium_impact	2.14	0.64	neutral	0.11	damaging	4.32	24.00	deleterious	0.35	0.5	0.55	disease	0.73	disease	0.61	disease	0.71	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.18	medium_impact	0.75	medium_impact	0.65	0.8	15.42	14.58	0.22	N	0.94	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13292	13292	T	C	MI.21285	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	956	319	I	T	aTc/aCc	1.56	0.78	0	probably_damaging	1	neutral	0.41	neutral	4.51	neutral	-1.18	deleterious	-4.34	low_impact	1.9	0.64	neutral	0.17	damaging	3.45	23.00	deleterious	0.51	0.6	0.4	neutral	0.58	disease	0.61	disease	0.69	disease	4	1	deleterious	0.21	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.15	medium_impact	0.53	medium_impact	0.74	0.85	15.42	14.58	0.25	N	0.94	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13292	13292	T	A	MI.21286	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	956	319	I	N	aTc/aAc	1.56	0.78	0	probably_damaging	1	neutral	0.34	neutral	4.49	deleterious	-3.83	deleterious	-6.11	medium_impact	3.09	0.63	neutral	0.12	damaging	4.47	24.20	deleterious	0.32	0.5	0.84	disease	0.79	disease	0.63	disease	0.78	disease	6	1	deleterious	0.17	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.07	medium_impact	1.62	medium_impact	0.68	0.85	15.42	14.58	0.29	N	0.98	polymorphism	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13293	13293	C	A	MI.21287	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	957	319	I	M	atC/atA	7.3	0.98	0	probably_damaging	1	neutral	0.3	neutral	4.52	neutral	-1.23	neutral	-2.38	low_impact	0.9	0.79	neutral	0.43	neutral	3.81	23.40	deleterious	0.6	0.65	0.49	neutral	0.51	disease	0.51	disease	0.49	neutral	0	1	deleterious	0.15	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.03	medium_impact	-0.38	medium_impact	0.87	0.9	15.42	14.58	0.49	N	0.29	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13293	13293	C	G	MI.21288	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	957	319	I	M	atC/atG	7.3	0.98	0	probably_damaging	1	neutral	0.3	neutral	4.52	neutral	-1.23	neutral	-2.38	low_impact	0.9	0.79	neutral	0.43	neutral	3.33	22.90	deleterious	0.6	0.65	0.49	neutral	0.51	disease	0.51	disease	0.49	neutral	0	1	deleterious	0.15	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.03	medium_impact	-0.38	medium_impact	0.87	0.9	15.42	14.58	0.48	N	0.29	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13294	13294	A	T	MI.21289	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	958	320	N	Y	Aac/Tac	-8.07	0	0	probably_damaging	0.98	neutral	1	neutral	4.47	neutral	-2.98	deleterious	-7.06	medium_impact	3.04	0.72	neutral	0.39	neutral	3.64	23.20	deleterious	0.31	0.45	0.82	disease	0.94	disease	0.66	disease	0.79	disease	6	0.98	deleterious	0.51	deleterious	1	deleterious	0.85	deleterious	-2.35	low_impact	1.89	high_impact	1.57	medium_impact	0.43	0.8	17.41	7.06	0.2	N	0.99	polymorphism	0.87	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6025	6025	T	G	MI.2129	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	122	41	L	R	cTg/cGg	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-7.54	deleterious	-3.69	high_impact	5.13	0.47	damaging	0.07	damaging	4.05	23.70	deleterious	0.17	0.55	0.93	disease	0.9	disease	0.75	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.57	0.9	2.53	7	0.6	P	0.90	polymorphism	0.83	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13294	13294	A	G	MI.21290	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	958	320	N	D	Aac/Gac	-8.07	0	0	possibly_damaging	0.85	neutral	0.22	neutral	4.57	neutral	-1.66	deleterious	-4.47	medium_impact	2.53	0.7	neutral	0.55	neutral	3.55	23.10	deleterious	0.55	0.6	0.61	disease	0.86	disease	0.71	disease	0.61	disease	2	0.9	neutral	0.19	neutral	0	NA	0.61	deleterious	-1.46	low_impact	-0.07	medium_impact	1.11	medium_impact	0.54	0.8	17.41	7.06	0.3	N	0.94	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13294	13294	A	C	MI.21291	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	958	320	N	H	Aac/Cac	-8.07	0	0	probably_damaging	0.98	neutral	0.56	neutral	4.48	neutral	-2.59	deleterious	-4.43	medium_impact	2.58	0.7	neutral	0.38	neutral	3.04	22.40	deleterious	0.49	0.55	0.7	disease	0.9	disease	0.72	disease	0.78	disease	6	0.98	deleterious	0.29	neutral	1	deleterious	0.82	deleterious	-2.35	low_impact	0.29	medium_impact	1.15	medium_impact	0.43	0.8	17.41	7.06	0.21	N	0.97	polymorphism	0.96	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13295	13295	A	G	MI.21292	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	959	320	N	S	aAc/aGc	3.85	0.99	0	possibly_damaging	0.74	neutral	0.45	neutral	4.58	neutral	-0.21	deleterious	-4.46	low_impact	1.29	0.7	neutral	0.67	neutral	2.03	16.43	deleterious	0.64	0.7	0.36	neutral	0.75	disease	0.64	disease	0.54	disease	1	0.74	neutral	0.36	neutral	-3	neutral	0.52	deleterious	-1.18	low_impact	0.18	medium_impact	-0.02	medium_impact	0.31	0.8	17.41	7.06	0.4	N	0.82	disease_causing	0.89	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13295	13295	A	C	MI.21293	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	959	320	N	T	aAc/aCc	3.85	0.99	0	probably_damaging	0.91	neutral	0.4	neutral	4.63	neutral	-0.92	deleterious	-5.35	medium_impact	3.38	0.68	neutral	0.47	neutral	3.66	23.20	deleterious	0.46	0.55	0.58	disease	0.89	disease	0.66	disease	0.74	disease	5	0.91	neutral	0.25	neutral	1	deleterious	0.73	deleterious	-1.7	low_impact	0.14	medium_impact	1.88	medium_impact	0.47	0.8	17.41	7.06	0.43	N	0.94	disease_causing	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13295	13295	A	T	MI.21294	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	959	320	N	I	aAc/aTc	3.85	0.99	0	probably_damaging	0.97	neutral	0.45	neutral	4.49	deleterious	-3.13	deleterious	-8.02	medium_impact	3.04	0.69	neutral	0.52	neutral	4.39	24.10	deleterious	0.28	0.45	0.84	disease	0.96	disease	0.66	disease	0.78	disease	6	0.97	neutral	0.24	neutral	1	deleterious	0.85	deleterious	-2.18	low_impact	0.18	medium_impact	1.57	medium_impact	0.31	0.8	17.41	7.06	0.43	N	0.99	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13296	13296	C	G	MI.21295	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	960	320	N	K	aaC/aaG	5.46	0.99	0	probably_damaging	0.91	neutral	0.3	neutral	4.56	neutral	-1.49	deleterious	-5.35	low_impact	1.51	0.68	neutral	0.5	neutral	3.80	23.40	deleterious	0.58	0.65	0.64	disease	0.93	disease	0.74	disease	0.77	disease	5	0.92	neutral	0.2	neutral	-2	neutral	0.73	deleterious	-1.7	low_impact	0.03	medium_impact	0.18	medium_impact	0.61	0.8	17.41	7.06	0.42	N	1.00	disease_causing	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13296	13296	C	A	MI.21296	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	960	320	N	K	aaC/aaA	5.46	0.99	0	probably_damaging	0.91	neutral	0.3	neutral	4.56	neutral	-1.49	deleterious	-5.35	low_impact	1.51	0.68	neutral	0.5	neutral	4.25	23.90	deleterious	0.58	0.65	0.64	disease	0.93	disease	0.74	disease	0.77	disease	5	0.92	neutral	0.2	neutral	-2	neutral	0.73	deleterious	-1.7	low_impact	0.03	medium_impact	0.18	medium_impact	0.61	0.8	17.41	7.06	0.42	N	1.00	disease_causing	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13297	13297	C	G	MI.21297	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	961	321	Q	E	Caa/Gaa	-3.71	0	0	probably_damaging	1	neutral	0.28	neutral	4.65	neutral	-0.34	deleterious	-2.7	medium_impact	2.31	0.67	neutral	0.16	damaging	3.13	22.60	deleterious	0.55	0.6	0.56	disease	0.82	disease	0.66	disease	0.69	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.01	medium_impact	0.91	medium_impact	0.61	0.8	18.91	6.94	0.24	N	0.92	disease_causing	0.57	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13297	13297	C	A	MI.21298	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	961	321	Q	K	Caa/Aaa	-3.71	0	0	probably_damaging	1	neutral	0.3	neutral	4.64	neutral	-1.08	deleterious	-3.6	medium_impact	2.27	0.69	neutral	0.12	damaging	4.11	23.70	deleterious	0.55	0.6	0.6	disease	0.9	disease	0.73	disease	0.79	disease	6	1	deleterious	0.15	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.03	medium_impact	0.87	medium_impact	0.58	0.8	18.91	6.94	0.23	N	0.96	disease_causing	0.74	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13298	13298	A	T	MI.21299	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	962	321	Q	L	cAa/cTa	4.31	0.99	0	probably_damaging	1	neutral	0.68	neutral	4.65	neutral	-1.39	deleterious	-6.31	neutral_impact	0.5	0.74	neutral	0.29	neutral	3.85	23.40	deleterious	0.41	0.5	0.45	neutral	0.8	disease	0.45	neutral	0.51	disease	0	1	deleterious	0.34	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.41	medium_impact	-0.75	medium_impact	0.28	0.8	18.91	6.94	0.32	N	0.96	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8626	8626	T	A	MI.213	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	100	34	S	T	Tcc/Acc	-6.12	0	0	probably_damaging	0.98	neutral	0.71	neutral	4.36	neutral	-0.44	neutral	-0.97	neutral_impact	0.18	0.88	neutral	0.95	neutral	1.95	15.92	deleterious	0.5	0.65	0.4	neutral	0.25	neutral	0.22	neutral	0.45	neutral	1	0.98	neutral	0.37	neutral	-2	neutral	0.66	deleterious	-2.36	low_impact	0.51	medium_impact	-0.94	medium_impact	0.84	0.9	9.73	14.65	0.34	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6027	6027	G	C	MI.2130	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	124	42	G	R	Ggc/Cgc	-4.5	0	0	probably_damaging	1	deleterious	0.01	neutral	2.8	deleterious	-4.33	deleterious	-3.73	medium_impact	2.94	0.6	damaging	0.07	damaging	3.71	23.30	deleterious	0.21	0.55	0.33	neutral	0.88	disease	0.53	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-0.92	medium_impact	1.62	medium_impact	0.81	0.9	2.53	7.03	0.23	N	0.95	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13298	13298	A	C	MI.21300	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	962	321	Q	P	cAa/cCa	4.31	0.99	0	probably_damaging	1	neutral	0.22	neutral	4.58	neutral	-2.09	deleterious	-5.41	medium_impact	3.03	0.62	neutral	0.12	damaging	3.39	23.00	deleterious	0.23	0.45	0.86	disease	0.91	disease	0.77	disease	0.84	disease	7	1	deleterious	0.11	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	-0.07	medium_impact	1.57	medium_impact	0.38	0.8	18.91	6.94	0.45	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13298	13298	A	G	MI.21301	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	962	321	Q	R	cAa/cGa	4.31	0.99	0	probably_damaging	1	neutral	0.35	neutral	4.59	neutral	-1.68	deleterious	-3.6	medium_impact	3.17	0.64	neutral	0.13	damaging	3.55	23.10	deleterious	0.55	0.6	0.72	disease	0.89	disease	0.7	disease	0.75	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.08	medium_impact	1.69	medium_impact	0.51	0.8	18.91	6.94	0.44	N	0.85	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13299	13299	A	C	MI.21302	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	963	321	Q	H	caA/caC	5.23	1	0	probably_damaging	1	neutral	0.55	neutral	4.57	neutral	-2.28	deleterious	-4.51	low_impact	1.78	0.78	neutral	0.17	damaging	3.97	23.60	deleterious	0.57	0.65	0.83	disease	0.8	disease	0.67	disease	0.67	disease	3	1	deleterious	0.28	neutral	-2	neutral	0.83	deleterious	-3.6	low_impact	0.28	medium_impact	0.42	medium_impact	0.70	0.85	18.91	6.94	0.39	N	0.94	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13299	13299	A	T	MI.21303	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	963	321	Q	H	caA/caT	5.23	1	0	probably_damaging	1	neutral	0.55	neutral	4.57	neutral	-2.28	deleterious	-4.51	low_impact	1.78	0.78	neutral	0.17	damaging	4.12	23.80	deleterious	0.57	0.65	0.83	disease	0.8	disease	0.67	disease	0.67	disease	3	1	deleterious	0.28	neutral	-2	neutral	0.83	deleterious	-3.6	low_impact	0.28	medium_impact	0.42	medium_impact	0.70	0.85	18.91	6.94	0.41	N	0.94	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13300	13300	C	T	MI.21304	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	964	322	P	S	Cca/Tca	-0.04	0.83	0	probably_damaging	1	neutral	0.56	neutral	4.72	neutral	1.39	deleterious	-7.21	medium_impact	2.68	0.49	damaging	0.03	damaging	3.89	23.50	deleterious	0.61	0.65	0.58	disease	0.83	disease	0.68	disease	0.64	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.29	medium_impact	1.25	medium_impact	0.23	0.8	28.03	7.21	0.28	N	0.78	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13300	13300	C	G	MI.21305	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	964	322	P	A	Cca/Gca	-0.04	0.83	0	probably_damaging	1	neutral	0.67	neutral	4.67	neutral	0.73	deleterious	-7.21	medium_impact	2.95	0.5	damaging	0.05	damaging	3.11	22.50	deleterious	0.42	0.55	0.62	disease	0.72	disease	0.7	disease	0.71	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.4	medium_impact	1.49	medium_impact	0.80	0.85	28.03	7.21	0.23	N	0.73	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13300	13300	C	A	MI.21306	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	964	322	P	T	Cca/Aca	-0.04	0.83	0	probably_damaging	1	neutral	0.52	neutral	4.69	neutral	1.03	deleterious	-7.21	medium_impact	2.77	0.5	damaging	0.03	damaging	3.86	23.50	deleterious	0.45	0.55	0.41	neutral	0.86	disease	0.7	disease	0.73	disease	5	1	deleterious	0.26	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.25	medium_impact	1.33	medium_impact	0.81	0.85	28.03	7.21	0.26	N	0.91	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13301	13301	C	T	MI.21307	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	965	322	P	L	cCa/cTa	4.31	1	0	probably_damaging	1	neutral	0.72	neutral	4.71	neutral	1.29	deleterious	-9.01	medium_impact	2.95	0.46	damaging	0.02	damaging	4.36	24.10	deleterious	0.64	0.7	0.62	disease	0.89	disease	0.68	disease	0.74	disease	5	1	deleterious	0.36	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.46	medium_impact	1.49	medium_impact	0.75	0.85	28.03	7.21	0.41	N	0.97	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13301	13301	C	G	MI.21308	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	965	322	P	R	cCa/cGa	4.31	1	0	probably_damaging	1	neutral	0.46	neutral	4.63	neutral	-0.32	deleterious	-8.11	medium_impact	2.84	0.55	damaging	0.03	damaging	3.59	23.20	deleterious	0.35	0.5	0.7	disease	0.93	disease	0.79	disease	0.79	disease	6	1	deleterious	0.23	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	0.19	medium_impact	1.39	medium_impact	0.59	0.8	28.03	7.21	0.39	N	0.64	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13301	13301	C	A	MI.21309	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	965	322	P	Q	cCa/cAa	4.31	1	0	probably_damaging	1	neutral	0.42	neutral	4.65	neutral	0.26	deleterious	-7.21	medium_impact	3.21	0.48	damaging	0.03	damaging	4.15	23.80	deleterious	0.32	0.5	0.69	disease	0.89	disease	0.7	disease	0.76	disease	5	1	deleterious	0.21	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.16	medium_impact	1.73	medium_impact	0.62	0.8	28.03	7.21	0.4	N	0.85	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6027	6027	G	T	MI.2131	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	124	42	G	C	Ggc/Tgc	-4.5	0	0	probably_damaging	1	deleterious	0.03	neutral	2.79	deleterious	-5.13	deleterious	-4.11	medium_impact	3.42	0.62	neutral	0.12	damaging	3.94	23.50	deleterious	0.22	0.55	0.56	disease	0.89	disease	0.41	neutral	0.76	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-0.65	medium_impact	2.06	high_impact	0.54	0.9	2.53	7.03	0.29	N	0.98	polymorphism	0.99	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13303	13303	C	T	MI.21310	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	967	323	H	Y	Cac/Tac	-20	0	0	benign	0.01	neutral	1	neutral	4.69	neutral	1.46	neutral	-2.48	neutral_impact	0.06	0.92	neutral	0.97	neutral	-0.07	1.96	neutral	0.56	0.6	0.55	disease	0.6	disease	0.4	neutral	0.49	neutral	0	0.01	neutral	1	deleterious	-6	neutral	0.26	neutral	1.15	medium_impact	1.89	high_impact	-1.15	low_impact	0.37	0.8	1.99	8.37	0.3	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	COSM488748	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13303	13303	C	G	MI.21311	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	967	323	H	D	Cac/Gac	-20	0	0	possibly_damaging	0.78	neutral	0.23	neutral	4.72	neutral	1.9	deleterious	-6.87	neutral_impact	-0.69	0.72	neutral	0.6	neutral	2.43	18.99	deleterious	0.28	0.45	0.56	disease	0.7	disease	0.76	disease	0.74	disease	5	0.86	neutral	0.23	neutral	-3	neutral	0.65	deleterious	-1.27	low_impact	-0.06	medium_impact	-1.83	low_impact	0.52	0.8	1.99	8.37	0.36	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13303	13303	C	A	MI.21312	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	967	323	H	N	Cac/Aac	-20	0	0	possibly_damaging	0.68	neutral	0.33	neutral	4.71	neutral	1.73	deleterious	-5.29	neutral_impact	-1.08	0.8	neutral	0.83	neutral	2.45	19.16	deleterious	0.48	0.55	0.37	neutral	0.55	disease	0.68	disease	0.5	neutral	0	0.74	neutral	0.33	neutral	-3	neutral	0.60	deleterious	-1.06	low_impact	0.06	medium_impact	-2.19	low_impact	0.53	0.8	1.99	8.37	0.3	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13304	13304	A	C	MI.21313	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	968	323	H	P	cAc/cCc	-0.96	0	0	probably_damaging	0.92	neutral	0.23	neutral	4.64	neutral	-0.29	deleterious	-7.55	low_impact	1.43	0.64	neutral	0.37	neutral	2.97	22.10	deleterious	0.27	0.45	0.79	disease	0.87	disease	0.77	disease	0.82	disease	6	0.94	neutral	0.16	neutral	-2	neutral	0.83	deleterious	-1.75	low_impact	-0.06	medium_impact	0.1	medium_impact	0.42	0.8	1.99	8.37	0.29	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13304	13304	A	G	MI.21314	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	968	323	H	R	cAc/cGc	-0.96	0	0	possibly_damaging	0.72	neutral	0.36	neutral	4.68	neutral	1.12	deleterious	-6.01	neutral_impact	0.68	0.7	neutral	0.5	neutral	0.25	5.20	deleterious	0.49	0.55	0.57	disease	0.74	disease	0.7	disease	0.76	disease	5	0.75	neutral	0.32	neutral	-3	neutral	0.66	deleterious	-1.14	low_impact	0.1	medium_impact	-0.58	medium_impact	0.34	0.8	1.99	8.37	0.26	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13304	13304	A	T	MI.21315	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	968	323	H	L	cAc/cTc	-0.96	0	0	possibly_damaging	0.44	neutral	0.68	neutral	4.66	neutral	0.6	deleterious	-7.67	neutral_impact	-0.58	0.77	neutral	0.61	neutral	0.87	9.88	deleterious	0.33	0.5	0.34	neutral	0.71	disease	0.66	disease	0.67	disease	3	0.35	neutral	0.62	deleterious	-3	neutral	0.41	neutral	-0.65	medium_impact	0.41	medium_impact	-1.73	low_impact	0.35	0.8	1.99	8.37	0.22	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13305	13305	C	A	MI.21316	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	969	323	H	Q	caC/caA	5.46	0.54	0	possibly_damaging	0.78	neutral	0.34	neutral	4.74	neutral	2.16	deleterious	-5.73	neutral_impact	-0.96	0.76	neutral	0.76	neutral	0.93	10.26	neutral	0.49	0.55	0.38	neutral	0.1	neutral	0.28	neutral	0.24	neutral	5	0.81	neutral	0.28	neutral	-3	neutral	0.56	deleterious	-1.27	low_impact	0.07	medium_impact	-2.08	low_impact	0.43	0.8	1.99	8.37	0.42	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13305	13305	C	G	MI.21317	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	969	323	H	Q	caC/caG	5.46	0.54	0	possibly_damaging	0.78	neutral	0.34	neutral	4.74	neutral	2.16	deleterious	-5.73	neutral_impact	-0.96	0.76	neutral	0.76	neutral	0.59	8.12	deleterious	0.49	0.55	0.38	neutral	0.1	neutral	0.28	neutral	0.24	neutral	5	0.81	neutral	0.28	neutral	-3	neutral	0.56	deleterious	-1.27	low_impact	0.07	medium_impact	-2.08	low_impact	0.43	0.8	1.99	8.37	0.42	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13306	13306	C	A	MI.21318	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	970	324	L	M	Cta/Ata	-0.27	0	0	possibly_damaging	0.76	neutral	0.28	neutral	4.46	neutral	-2.49	neutral	-1.77	medium_impact	2.75	0.65	neutral	0.45	neutral	3.96	23.60	deleterious	0.34	0.5	0.86	disease	0.61	disease	0.46	neutral	0.59	disease	2	0.82	neutral	0.26	neutral	0	NA	0.78	deleterious	-1.22	low_impact	0.01	medium_impact	1.31	medium_impact	0.75	0.85	13.27	7.1	0.35	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13306	13306	C	G	MI.21319	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	970	324	L	V	Cta/Gta	-0.27	0	0	possibly_damaging	0.9	neutral	0.64	neutral	4.54	neutral	-1.14	deleterious	-2.67	low_impact	1.63	0.67	neutral	0.35	neutral	3.45	23.00	deleterious	0.37	0.5	0.64	disease	0.55	disease	0.63	disease	0.5	neutral	0	0.88	neutral	0.37	neutral	-3	neutral	0.76	deleterious	-1.65	low_impact	0.37	medium_impact	0.29	medium_impact	0.59	0.8	13.27	7.1	0.19	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6027	6027	G	A	MI.2132	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	124	42	G	S	Ggc/Agc	-4.5	0	0	probably_damaging	1	neutral	1	neutral	2.87	neutral	-2.49	neutral	-2.18	neutral_impact	0.62	0.64	neutral	0.4	neutral	2.46	19.20	deleterious	0.38	0.55	0.2	neutral	0.38	neutral	0.18	neutral	0.45	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.69	deleterious	-3.58	low_impact	1.86	high_impact	-0.53	medium_impact	0.80	0.9	2.53	7.03	0.29	N	0.73	polymorphism	1	0.08	rs879057311	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13307	13307	T	C	MI.21320	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	971	324	L	P	cTa/cCa	-1.65	0	0	probably_damaging	1	neutral	0.38	neutral	4.41	deleterious	-5.1	deleterious	-6.22	high_impact	3.62	0.6	damaging	0.32	neutral	3.97	23.60	deleterious	0.15	0.4	0.83	disease	0.85	disease	0.75	disease	0.77	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.12	medium_impact	2.1	high_impact	0.51	0.8	13.27	7.1	0.3	N	0.99	disease_causing	0.97	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13307	13307	T	A	MI.21321	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	971	324	L	Q	cTa/cAa	-1.65	0	0	probably_damaging	0.99	neutral	0.71	neutral	4.42	deleterious	-4.21	deleterious	-5.31	high_impact	4.04	0.64	neutral	0.34	neutral	4.16	23.80	deleterious	0.18	0.45	0.9	disease	0.86	disease	0.64	disease	0.78	disease	6	0.99	deleterious	0.36	neutral	2	deleterious	0.86	deleterious	-2.64	low_impact	0.45	medium_impact	2.49	high_impact	0.61	0.8	13.27	7.1	0.3	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13307	13307	T	G	MI.21322	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	971	324	L	R	cTa/cGa	-1.65	0	0	probably_damaging	0.98	neutral	0.69	neutral	4.43	deleterious	-4.83	deleterious	-5.31	high_impact	4.58	0.6	damaging	0.3	neutral	4.22	23.90	deleterious	0.14	0.4	0.89	disease	0.9	disease	0.69	disease	0.79	disease	6	0.98	deleterious	0.36	neutral	2	deleterious	0.91	deleterious	-2.35	low_impact	0.42	medium_impact	2.98	high_impact	0.48	0.8	13.27	7.1	0.42	N	1.00	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13309	13309	G	T	MI.21323	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	973	325	A	S	Gca/Tca	-0.73	0.06	0	probably_damaging	1	neutral	0.55	neutral	4.33	deleterious	-3.41	neutral	-2.48	medium_impact	2.82	0.63	neutral	0.28	damaging	3.71	23.30	deleterious	0.27	0.45	0.61	disease	0.76	disease	0.57	disease	0.54	disease	1	1	deleterious	0.28	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.28	medium_impact	1.37	medium_impact	0.80	0.85	20.73	7.08	0.22	N	0.98	disease_causing	0.91	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13309	13309	G	A	MI.21324	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	973	325	A	T	Gca/Aca	-0.73	0.06	0	probably_damaging	1	neutral	0.49	neutral	4.26	deleterious	-4.31	deleterious	-3.43	medium_impact	3.23	0.58	damaging	0.43	neutral	4.23	23.90	deleterious	0.29	0.45	0.8	disease	0.85	disease	0.59	disease	0.6	disease	2	1	deleterious	0.25	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.22	medium_impact	1.75	medium_impact	0.59	0.8	20.73	7.08	0.27	N	0.94	disease_causing	0.96	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13309	13309	G	C	MI.21325	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	973	325	A	P	Gca/Cca	-0.73	0.06	0	probably_damaging	1	neutral	0.28	neutral	4.18	deleterious	-6.74	deleterious	-4.39	high_impact	4.96	0.54	damaging	0.08	damaging	3.85	23.40	deleterious	0.13	0.4	0.64	disease	0.9	disease	0.78	disease	0.79	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.01	medium_impact	3.33	high_impact	0.68	0.85	20.73	7.08	0.67	P	0.96	disease_causing	0.99	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13310	13310	C	G	MI.21326	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	974	325	A	G	gCa/gGa	7.07	1	0	probably_damaging	1	neutral	0.4	neutral	4.3	neutral	-2.54	deleterious	-3.5	low_impact	1.94	0.57	damaging	0.16	damaging	3.93	23.50	deleterious	0.23	0.45	0.63	disease	0.76	disease	0.64	disease	0.54	disease	1	1	deleterious	0.2	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	0.14	medium_impact	0.57	medium_impact	0.80	0.85	20.73	7.08	0.48	N	0.82	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13310	13310	C	A	MI.21327	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	974	325	A	E	gCa/gAa	7.07	1	0	probably_damaging	1	neutral	0.45	neutral	4.21	deleterious	-5.03	deleterious	-4.36	high_impact	4.96	0.57	damaging	0.09	damaging	4.61	24.40	deleterious	0.1	0.4	0.89	disease	0.91	disease	0.76	disease	0.82	disease	6	1	deleterious	0.23	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.18	medium_impact	3.33	high_impact	0.62	0.8	20.73	7.08	0.77	P	0.99	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13310	13310	C	T	MI.21328	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	974	325	A	V	gCa/gTa	7.07	1	0	probably_damaging	1	neutral	0.54	neutral	4.25	deleterious	-4.16	deleterious	-3.56	high_impact	3.64	0.54	damaging	0.07	damaging	4.45	24.20	deleterious	0.36	0.5	0.73	disease	0.87	disease	0.61	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.27	medium_impact	2.12	high_impact	0.56	0.8	20.73	7.08	0.52	P	0.76	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13312	13312	T	A	MI.21329	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	976	326	F	I	Ttc/Atc	-6.01	0	0	possibly_damaging	0.74	neutral	0.45	neutral	4.74	neutral	0.37	deleterious	-5.41	low_impact	1.5	0.66	neutral	0.6	neutral	2.80	21.40	deleterious	0.22	0.45	0.36	neutral	0.83	disease	0.69	disease	0.55	disease	1	0.74	neutral	0.36	neutral	-3	neutral	0.50	deleterious	-1.18	low_impact	0.18	medium_impact	0.17	medium_impact	0.72	0.85	26.87	7.2	0.28	N	0.83	polymorphism	0.74	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6028	6028	G	A	MI.2133	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	125	42	G	D	gGc/gAc	4.75	1	0	probably_damaging	1	deleterious	0.01	neutral	2.79	deleterious	-4.44	deleterious	-3.23	high_impact	4.39	0.58	damaging	0.08	damaging	3.64	23.20	deleterious	0.2	0.55	0.38	neutral	0.88	disease	0.62	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-0.92	medium_impact	2.95	high_impact	0.36	0.9	2.53	7.03	0.44	N	0.97	disease_causing	1	0.21	rs28580752	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13312	13312	T	G	MI.21330	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	976	326	F	V	Ttc/Gtc	-6.01	0	0	possibly_damaging	0.74	neutral	0.54	neutral	4.63	neutral	0.21	deleterious	-6.31	medium_impact	2.4	0.68	neutral	0.46	neutral	2.52	19.61	deleterious	0.21	0.45	0.46	neutral	0.84	disease	0.71	disease	0.57	disease	1	0.71	neutral	0.4	neutral	0	NA	0.51	deleterious	-1.18	low_impact	0.27	medium_impact	0.99	medium_impact	0.70	0.85	26.87	7.2	0.25	N	0.91	polymorphism	0.57	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13312	13312	T	C	MI.21331	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	976	326	F	L	Ttc/Ctc	-6.01	0	0	benign	0.08	neutral	0.72	neutral	4.73	neutral	0.75	deleterious	-5.41	low_impact	0.92	0.68	neutral	0.69	neutral	2.14	17.11	deleterious	0.27	0.45	0.37	neutral	0.71	disease	0.68	disease	0.54	disease	1	0.18	neutral	0.82	deleterious	-6	neutral	0.18	neutral	0.26	medium_impact	0.46	medium_impact	-0.36	medium_impact	0.66	0.8	26.87	7.2	0.27	N	0.44	polymorphism	0.72	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13313	13313	T	A	MI.21332	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	977	326	F	Y	tTc/tAc	4.54	1	0	possibly_damaging	0.89	neutral	1	neutral	4.64	neutral	-2.75	deleterious	-2.7	medium_impact	2.81	0.66	neutral	0.45	neutral	4.16	23.80	deleterious	0.23	0.45	0.59	disease	0.84	disease	0.66	disease	0.72	disease	4	0.89	neutral	0.56	deleterious	0	NA	0.69	deleterious	-1.61	low_impact	1.89	high_impact	1.36	medium_impact	0.70	0.85	26.87	7.2	0.43	N	0.69	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13313	13313	T	G	MI.21333	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	977	326	F	C	tTc/tGc	4.54	1	0	probably_damaging	0.98	neutral	0.19	neutral	4.54	deleterious	-4.31	deleterious	-7.21	high_impact	3.85	0.67	neutral	0.47	neutral	4.08	23.70	deleterious	0.23	0.45	0.84	disease	0.88	disease	0.72	disease	0.77	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-2.35	low_impact	-0.12	medium_impact	2.31	high_impact	0.45	0.8	26.87	7.2	0.48	N	0.95	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13313	13313	T	C	MI.21334	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	977	326	F	S	tTc/tCc	4.54	1	0	probably_damaging	0.96	neutral	0.52	neutral	4.57	neutral	-2.31	deleterious	-7.21	high_impact	3.56	0.72	neutral	0.54	neutral	4.17	23.80	deleterious	0.21	0.45	0.62	disease	0.84	disease	0.7	disease	0.73	disease	5	0.95	neutral	0.28	neutral	2	deleterious	0.74	deleterious	-2.06	low_impact	0.25	medium_impact	2.05	high_impact	0.59	0.8	26.87	7.2	0.45	N	0.98	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13314	13314	C	A	MI.21335	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	978	326	F	L	ttC/ttA	5.69	1	0	benign	0.08	neutral	0.72	neutral	4.73	neutral	0.75	deleterious	-5.41	low_impact	0.92	0.68	neutral	0.69	neutral	2.79	21.30	deleterious	0.27	0.45	0.37	neutral	0.71	disease	0.68	disease	0.54	disease	1	0.18	neutral	0.82	deleterious	-6	neutral	0.18	neutral	0.26	medium_impact	0.46	medium_impact	-0.36	medium_impact	0.66	0.8	26.87	7.2	0.45	N	0.44	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13314	13314	C	G	MI.21336	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	978	326	F	L	ttC/ttG	5.69	1	0	benign	0.08	neutral	0.72	neutral	4.73	neutral	0.75	deleterious	-5.41	low_impact	0.92	0.68	neutral	0.69	neutral	2.47	19.27	deleterious	0.27	0.45	0.37	neutral	0.71	disease	0.68	disease	0.54	disease	1	0.18	neutral	0.82	deleterious	-6	neutral	0.18	neutral	0.26	medium_impact	0.46	medium_impact	-0.36	medium_impact	0.66	0.8	26.87	7.2	0.45	N	0.44	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13315	13315	C	G	MI.21337	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	979	327	L	V	Ctg/Gtg	-2.34	0	0	probably_damaging	1	neutral	0.52	neutral	4.49	neutral	-1.67	neutral	-2.3	medium_impact	1.94	0.67	neutral	0.1	damaging	3.47	23.10	deleterious	0.23	0.45	0.62	disease	0.67	disease	0.58	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.25	medium_impact	0.57	medium_impact	0.65	0.8	5.47	11.02	0.18	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13315	13315	C	A	MI.21338	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	979	327	L	M	Ctg/Atg	-2.34	0	0	probably_damaging	1	neutral	0.25	neutral	4.45	neutral	-2.55	neutral	-1.29	low_impact	1.52	0.71	neutral	0.43	neutral	3.73	23.30	deleterious	0.24	0.45	0.75	disease	0.51	disease	0.36	neutral	0.52	disease	0	1	deleterious	0.13	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	-0.03	medium_impact	0.19	medium_impact	0.68	0.85	5.47	11.02	0.35	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13316	13316	T	A	MI.21339	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	980	327	L	Q	cTg/cAg	-0.04	0	0	probably_damaging	1	neutral	0.38	neutral	4.38	deleterious	-4.94	deleterious	-4.84	medium_impact	3.19	0.66	neutral	0.1	damaging	4.21	23.90	deleterious	0.14	0.4	0.76	disease	0.85	disease	0.58	disease	0.7	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.12	medium_impact	1.71	medium_impact	0.70	0.85	5.47	11.02	0.24	N	0.98	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6028	6028	G	T	MI.2134	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	125	42	G	V	gGc/gTc	4.75	1	0	probably_damaging	1	deleterious	0.01	neutral	2.93	neutral	-1.98	deleterious	-4.21	high_impact	3.69	0.63	neutral	0.09	damaging	3.63	23.20	deleterious	0.23	0.55	0.22	neutral	0.82	disease	0.4	neutral	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-0.92	medium_impact	2.31	high_impact	0.54	0.9	2.53	7.03	0.44	N	0.93	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13316	13316	T	C	MI.21340	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	980	327	L	P	cTg/cCg	-0.04	0	0	probably_damaging	1	neutral	0.22	neutral	4.37	deleterious	-5.63	deleterious	-5.77	high_impact	3.73	0.6	neutral	0.09	damaging	3.93	23.50	deleterious	0.13	0.4	0.92	disease	0.88	disease	0.71	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.07	medium_impact	2.2	high_impact	0.58	0.8	5.47	11.02	0.28	N	0.99	disease_causing	0.63	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13316	13316	T	G	MI.21341	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	980	327	L	R	cTg/cGg	-0.04	0	0	probably_damaging	1	neutral	0.38	neutral	4.38	deleterious	-5.07	deleterious	-4.91	medium_impact	3.39	0.6	damaging	0.09	damaging	4.21	23.90	deleterious	0.12	0.4	0.9	disease	0.91	disease	0.7	disease	0.81	disease	6	1	deleterious	0.19	neutral	1	deleterious	0.90	deleterious	-3.6	low_impact	0.12	medium_impact	1.89	medium_impact	0.50	0.8	5.47	11.02	0.24	N	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13318	13318	C	G	MI.21342	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	982	328	H	D	Cac/Gac	-20	0	0	probably_damaging	1	neutral	0.3	neutral	4.45	deleterious	-5.22	deleterious	-8.11	high_impact	5.14	0.38	damaging	0.02	damaging	3.87	23.50	deleterious	0.2	0.45	0.91	disease	0.88	disease	0.81	disease	0.84	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.03	medium_impact	3.49	high_impact	0.56	0.8	28.69	7.22	0.49	N	0.97	polymorphism	0.53	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13318	13318	C	A	MI.21343	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	982	328	H	N	Cac/Aac	-20	0	0	probably_damaging	1	neutral	0.37	neutral	4.48	deleterious	-4.55	deleterious	-6.31	high_impact	4.46	0.38	damaging	0.02	damaging	3.90	23.50	deleterious	0.29	0.45	0.65	disease	0.87	disease	0.75	disease	0.76	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.11	medium_impact	2.87	high_impact	0.57	0.8	28.69	7.22	0.4	N	0.97	polymorphism	0.79	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13318	13318	C	T	MI.21344	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	982	328	H	Y	Cac/Tac	-20	0	0	probably_damaging	1	neutral	1	neutral	4.55	neutral	-2.19	deleterious	-5.41	high_impact	3.6	0.38	damaging	0.02	damaging	3.71	23.30	deleterious	0.27	0.45	0.69	disease	0.91	disease	0.77	disease	0.77	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.84	deleterious	-3.6	low_impact	1.89	high_impact	2.09	high_impact	0.51	0.8	28.69	7.22	0.37	N	1.00	polymorphism	0.75	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13319	13319	A	T	MI.21345	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	983	328	H	L	cAc/cTc	7.07	1	0	probably_damaging	1	neutral	0.73	neutral	4.65	deleterious	-3.24	deleterious	-9.91	medium_impact	2.96	0.41	damaging	0.02	damaging	3.86	23.50	deleterious	0.19	0.45	0.66	disease	0.92	disease	0.72	disease	0.74	disease	5	1	deleterious	0.37	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.47	medium_impact	1.5	medium_impact	0.46	0.8	28.69	7.22	0.56	P	0.97	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13319	13319	A	C	MI.21346	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	983	328	H	P	cAc/cCc	7.07	1	0	probably_damaging	1	neutral	0.27	neutral	4.45	deleterious	-6.27	deleterious	-9.01	high_impact	5.14	0.34	damaging	0.04	damaging	3.30	22.90	deleterious	0.23	0.45	0.94	disease	0.9	disease	0.84	disease	0.83	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.01	medium_impact	3.49	high_impact	0.49	0.8	28.69	7.22	0.69	P	0.97	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13319	13319	A	G	MI.21347	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	983	328	H	R	cAc/cGc	7.07	1	0	probably_damaging	1	neutral	0.42	neutral	4.46	deleterious	-5.06	deleterious	-7.21	high_impact	5.14	0.43	damaging	0.03	damaging	3.02	22.30	deleterious	0.26	0.45	0.89	disease	0.9	disease	0.79	disease	0.83	disease	7	1	deleterious	0.21	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.16	medium_impact	3.49	high_impact	0.52	0.8	28.69	7.22	0.7	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13320	13320	C	G	MI.21348	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	984	328	H	Q	caC/caG	8.44	1	0	probably_damaging	1	neutral	0.38	neutral	4.51	neutral	-2.15	deleterious	-7.21	high_impact	4.17	0.43	damaging	0.02	damaging	3.55	23.10	deleterious	0.33	0.5	0.73	disease	0.88	disease	0.75	disease	0.75	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.12	medium_impact	2.61	high_impact	0.68	0.85	28.69	7.22	0.63	P	0.95	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13320	13320	C	A	MI.21349	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	984	328	H	Q	caC/caA	8.44	1	0	probably_damaging	1	neutral	0.38	neutral	4.51	neutral	-2.15	deleterious	-7.21	high_impact	4.17	0.43	damaging	0.02	damaging	3.97	23.60	deleterious	0.33	0.5	0.73	disease	0.88	disease	0.75	disease	0.75	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.12	medium_impact	2.61	high_impact	0.68	0.85	28.69	7.22	0.63	P	0.95	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6028	6028	G	C	MI.2135	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	125	42	G	A	gGc/gCc	4.75	1	0	probably_damaging	1	neutral	0.23	neutral	3.01	neutral	-1.29	neutral	-2.36	low_impact	1.36	0.64	neutral	0.22	damaging	1.78	14.88	neutral	0.47	0.55	0.27	neutral	0.49	neutral	0.2	neutral	0.44	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.71	deleterious	-3.58	low_impact	-0.1	medium_impact	0.16	medium_impact	0.57	0.9	2.53	7.03	0.52	P	0.64	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13321	13321	A	C	MI.21350	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	985	329	I	L	Atc/Ctc	-0.27	0.39	0	benign	0.38	neutral	0.71	neutral	4.92	neutral	1.86	neutral	-1.7	neutral_impact	-0.3	0.63	neutral	0.69	neutral	3.65	23.20	deleterious	0.25	0.45	0.39	neutral	0.41	neutral	0.66	disease	0.43	neutral	1	0.28	neutral	0.67	deleterious	-6	neutral	0.64	deleterious	-0.54	medium_impact	0.45	medium_impact	-1.48	low_impact	0.67	0.85	5.47	10.14	0.32	N	0.86	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13321	13321	A	T	MI.21351	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	985	329	I	F	Atc/Ttc	-0.27	0.39	0	probably_damaging	0.91	neutral	0.74	neutral	4.61	neutral	-2.42	deleterious	-3.5	medium_impact	2.86	0.61	neutral	0.38	neutral	3.67	23.20	deleterious	0.21	0.45	0.75	disease	0.82	disease	0.68	disease	0.69	disease	4	0.9	neutral	0.42	neutral	1	deleterious	0.80	deleterious	-1.7	low_impact	0.48	medium_impact	1.41	medium_impact	0.75	0.85	5.47	10.14	0.24	N	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13321	13321	A	G	MI.21352	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	985	329	I	V	Atc/Gtc	-0.27	0.39	0	benign	0.08	neutral	0.53	neutral	4.62	neutral	-0.32	neutral	-0.86	medium_impact	2.12	0.61	neutral	0.48	neutral	2.93	22.00	deleterious	0.36	0.5	0.62	disease	0.45	neutral	0.59	disease	0.61	disease	2	0.4	neutral	0.73	deleterious	-3	neutral	0.67	deleterious	0.26	medium_impact	0.26	medium_impact	0.73	medium_impact	0.57	0.8	5.47	10.14	0.31	N	0.74	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13322	13322	T	C	MI.21353	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	986	329	I	T	aTc/aCc	8.44	1	0	possibly_damaging	0.87	neutral	0.42	neutral	4.58	neutral	-2	deleterious	-4.4	medium_impact	2.31	0.61	neutral	0.4	neutral	3.41	23.00	deleterious	0.3	0.45	0.77	disease	0.77	disease	0.66	disease	0.7	disease	4	0.86	neutral	0.28	neutral	0	NA	0.80	deleterious	-1.53	low_impact	0.16	medium_impact	0.91	medium_impact	0.60	0.8	5.47	10.14	0.52	P	0.96	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13322	13322	T	G	MI.21354	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	986	329	I	S	aTc/aGc	8.44	1	0	possibly_damaging	0.9	neutral	0.43	neutral	4.54	neutral	-2.49	deleterious	-5.26	high_impact	3.56	0.62	neutral	0.47	neutral	4.32	24.00	deleterious	0.21	0.45	0.71	disease	0.83	disease	0.66	disease	0.7	disease	4	0.9	neutral	0.27	neutral	1	deleterious	0.81	deleterious	-1.65	low_impact	0.17	medium_impact	2.05	high_impact	0.48	0.8	5.47	10.14	0.58	P	0.96	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13322	13322	T	A	MI.21355	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	986	329	I	N	aTc/aAc	8.44	1	0	probably_damaging	0.96	neutral	0.31	neutral	4.51	deleterious	-3.62	deleterious	-6.17	high_impact	3.9	0.6	damaging	0.43	neutral	4.44	24.20	deleterious	0.19	0.45	0.53	disease	0.85	disease	0.67	disease	0.72	disease	4	0.97	neutral	0.18	neutral	2	deleterious	0.77	deleterious	-2.06	low_impact	0.04	medium_impact	2.36	high_impact	0.63	0.8	5.47	10.14	0.55	P	0.99	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13323	13323	C	A	MI.21356	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	987	329	I	M	atC/atA	7.3	1	0	possibly_damaging	0.49	neutral	0.25	neutral	4.71	neutral	0.35	neutral	-2.46	neutral_impact	0.6	0.73	neutral	0.86	neutral	3.73	23.30	deleterious	0.25	0.45	0.47	neutral	0.51	disease	0.57	disease	0.46	neutral	1	0.73	neutral	0.38	neutral	-3	neutral	0.69	deleterious	-0.73	medium_impact	-0.03	medium_impact	-0.66	medium_impact	0.72	0.85	5.47	10.14	0.53	P	0.76	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13323	13323	C	G	MI.21357	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	987	329	I	M	atC/atG	7.3	1	0	possibly_damaging	0.49	neutral	0.25	neutral	4.71	neutral	0.35	neutral	-2.46	neutral_impact	0.6	0.73	neutral	0.86	neutral	3.35	22.90	deleterious	0.25	0.45	0.47	neutral	0.51	disease	0.57	disease	0.46	neutral	1	0.73	neutral	0.38	neutral	-3	neutral	0.69	deleterious	-0.73	medium_impact	-0.03	medium_impact	-0.66	medium_impact	0.72	0.85	5.47	10.14	0.53	P	0.76	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13324	13324	T	A	MI.21358	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	988	330	C	S	Tgt/Agt	-1.88	0	0	probably_damaging	1	neutral	0.47	neutral	4.63	neutral	0.11	deleterious	-9.01	low_impact	1.21	0.61	neutral	0.25	damaging	3.52	23.10	deleterious	0.34	0.5	0.56	disease	0.63	disease	0.56	disease	0.49	neutral	0	1	deleterious	0.24	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.2	medium_impact	-0.1	medium_impact	0.74	0.85	24.54	7.17	0.26	N	0.45	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13324	13324	T	C	MI.21359	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	988	330	C	R	Tgt/Cgt	-1.88	0	0	probably_damaging	1	neutral	0.38	neutral	4.61	neutral	-1.4	deleterious	-10.81	high_impact	3.62	0.41	damaging	0.05	damaging	3.46	23.00	deleterious	0.27	0.45	0.84	disease	0.95	disease	0.78	disease	0.85	disease	7	1	deleterious	0.19	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.12	medium_impact	2.1	high_impact	0.49	0.8	24.54	7.17	0.53	P	0.89	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6030	6030	C	G	MI.2136	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	127	43	Q	E	Cag/Gag	-8.43	0	0	probably_damaging	0.95	deleterious	0.04	neutral	2.98	neutral	-2.22	neutral	-1.24	medium_impact	2.56	0.6	neutral	0.37	neutral	2.95	22.00	deleterious	0.55	0.6	0.23	neutral	0.6	disease	0.31	neutral	0.44	neutral	1	0.99	deleterious	0.05	neutral	5	deleterious	0.70	deleterious	-1.96	low_impact	-0.58	medium_impact	1.27	medium_impact	0.59	0.9	2.73	6.75	0.42	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13324	13324	T	G	MI.21360	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	988	330	C	G	Tgt/Ggt	-1.88	0	0	probably_damaging	1	neutral	0.44	neutral	4.61	neutral	-0.64	deleterious	-10.81	medium_impact	2.92	0.47	damaging	0.06	damaging	3.31	22.90	deleterious	0.31	0.45	0.74	disease	0.91	disease	0.69	disease	0.75	disease	5	1	deleterious	0.22	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.18	medium_impact	1.46	medium_impact	0.64	0.8	24.54	7.17	0.29	N	0.79	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13325	13325	G	A	MI.21361	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	989	330	C	Y	tGt/tAt	4.31	1	0	probably_damaging	1	neutral	0.87	neutral	4.71	neutral	0	deleterious	-9.91	medium_impact	2.05	0.43	damaging	0.04	damaging	3.60	23.20	deleterious	0.31	0.45	0.7	disease	0.94	disease	0.72	disease	0.85	disease	7	1	deleterious	0.44	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.69	medium_impact	0.67	medium_impact	0.71	0.85	24.54	7.17	0.42	N	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13325	13325	G	T	MI.21362	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	989	330	C	F	tGt/tTt	4.31	1	0	probably_damaging	1	neutral	0.79	neutral	4.67	neutral	2.31	deleterious	-9.91	low_impact	1.06	0.44	damaging	0.05	damaging	3.93	23.50	deleterious	0.32	0.5	0.47	neutral	0.93	disease	0.68	disease	0.56	disease	1	1	deleterious	0.4	neutral	-2	neutral	0.81	deleterious	-3.6	low_impact	0.55	medium_impact	-0.23	medium_impact	0.64	0.8	24.54	7.17	0.41	N	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13325	13325	G	C	MI.21363	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	989	330	C	S	tGt/tCt	4.31	1	0	probably_damaging	1	neutral	0.47	neutral	4.63	neutral	0.11	deleterious	-9.01	low_impact	1.21	0.61	neutral	0.25	damaging	3.21	22.70	deleterious	0.34	0.5	0.56	disease	0.63	disease	0.56	disease	0.49	neutral	0	1	deleterious	0.24	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.2	medium_impact	-0.1	medium_impact	0.74	0.85	24.54	7.17	0.34	N	0.45	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13326	13326	T	A	MI.21364	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	990	330	C	W	tgT/tgA	5.69	1	0.03	probably_damaging	1	neutral	0.16	neutral	4.6	neutral	-1.72	deleterious	-9.91	medium_impact	2.92	0.46	damaging	0.04	damaging	4.37	24.10	deleterious	0.24	0.45	0.77	disease	0.94	disease	0.74	disease	0.86	disease	7	1	deleterious	0.08	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.17	medium_impact	1.46	medium_impact	0.52	0.8	24.54	7.17	0.5	P	0.96	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13326	13326	T	G	MI.21365	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	990	330	C	W	tgT/tgG	5.69	1	0.03	probably_damaging	1	neutral	0.16	neutral	4.6	neutral	-1.72	deleterious	-9.91	medium_impact	2.92	0.46	damaging	0.04	damaging	4.25	23.90	deleterious	0.24	0.45	0.77	disease	0.94	disease	0.74	disease	0.86	disease	7	1	deleterious	0.08	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.17	medium_impact	1.46	medium_impact	0.52	0.8	24.54	7.17	0.49	P	0.96	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13327	13327	A	T	MI.21366	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	991	331	T	S	Acc/Tcc	-2.11	0	0	probably_damaging	1	neutral	0.56	neutral	4.59	neutral	-0.76	deleterious	-2.9	medium_impact	1.99	0.79	neutral	0.5	neutral	3.40	23.00	deleterious	0.36	0.5	0.56	disease	0.64	disease	0.63	disease	0.65	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.70	deleterious	-3.6	low_impact	0.29	medium_impact	0.62	medium_impact	0.70	0.85	4.15	7.89	0.19	N	0.89	disease_causing	0.85	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13327	13327	A	C	MI.21367	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	991	331	T	P	Acc/Ccc	-2.11	0	0	probably_damaging	1	neutral	0.22	neutral	4.41	deleterious	-5.1	deleterious	-4.65	high_impact	4.66	0.76	neutral	0.37	neutral	3.59	23.20	deleterious	0.19	0.45	0.91	disease	0.81	disease	0.75	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	-0.07	medium_impact	3.05	high_impact	0.55	0.8	4.15	7.89	0.59	P	0.97	disease_causing	0.99	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13327	13327	A	G	MI.21368	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	991	331	T	A	Acc/Gcc	-2.11	0	0	probably_damaging	1	neutral	0.69	neutral	4.55	neutral	-0.33	deleterious	-3.8	medium_impact	2.38	0.87	neutral	0.54	neutral	3.54	23.10	deleterious	0.35	0.5	0.52	disease	0.55	disease	0.63	disease	0.63	disease	3	1	deleterious	0.35	neutral	1	deleterious	0.67	deleterious	-3.6	low_impact	0.42	medium_impact	0.97	medium_impact	0.50	0.8	4.15	7.89	0.23	N	0.69	disease_causing	0.94	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13328	13328	C	T	MI.21369	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	992	331	T	I	aCc/aTc	8.44	1	0	probably_damaging	1	neutral	0.46	neutral	4.57	neutral	-2.21	deleterious	-4.38	medium_impact	3.1	0.68	neutral	0.57	neutral	4.00	23.60	deleterious	0.25	0.45	0.74	disease	0.87	disease	0.63	disease	0.7	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.19	medium_impact	1.63	medium_impact	0.58	0.8	4.15	7.89	0.51	P	0.95	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6030	6030	C	A	MI.2137	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	127	43	Q	K	Cag/Aag	-8.43	0	0	probably_damaging	0.98	neutral	0.19	neutral	2.95	neutral	-1.78	neutral	-1.64	medium_impact	2.84	0.63	neutral	0.39	neutral	3.78	23.40	deleterious	0.48	0.55	0.2	neutral	0.75	disease	0.34	neutral	0.6	disease	2	0.98	deleterious	0.11	neutral	1	deleterious	0.71	deleterious	-2.35	low_impact	-0.16	medium_impact	1.52	medium_impact	0.58	0.9	2.73	6.75	0.42	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13328	13328	C	A	MI.21370	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	992	331	T	N	aCc/aAc	8.44	1	0	probably_damaging	1	neutral	0.32	neutral	4.41	neutral	-0.04	deleterious	-3.48	medium_impact	2.47	0.76	neutral	0.68	neutral	3.63	23.20	deleterious	0.33	0.5	0.45	neutral	0.68	disease	0.58	disease	0.5	neutral	0	1	deleterious	0.16	neutral	1	deleterious	0.68	deleterious	-3.6	low_impact	0.05	medium_impact	1.05	medium_impact	0.77	0.85	4.15	7.89	0.51	P	0.93	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13328	13328	C	G	MI.21371	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	992	331	T	S	aCc/aGc	8.44	1	0	probably_damaging	1	neutral	0.56	neutral	4.59	neutral	-0.76	deleterious	-2.9	medium_impact	1.99	0.79	neutral	0.5	neutral	3.54	23.10	deleterious	0.36	0.5	0.56	disease	0.64	disease	0.63	disease	0.65	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.70	deleterious	-3.6	low_impact	0.29	medium_impact	0.62	medium_impact	0.70	0.85	4.15	7.89	0.45	N	0.89	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13330	13330	C	A	MI.21372	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	994	332	H	N	Cac/Aac	-11.28	0	0	probably_damaging	1	neutral	0.39	neutral	3.89	deleterious	-5.8	deleterious	-6.31	high_impact	4.9	0.39	damaging	0.07	damaging	3.97	23.60	deleterious	0.22	0.45	0.82	disease	0.84	disease	0.78	disease	0.8	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.13	medium_impact	3.27	high_impact	0.30	0.8	29.02	7.19	0.53	P	0.97	polymorphism	0.75	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13330	13330	C	G	MI.21373	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	994	332	H	D	Cac/Gac	-11.28	0	0	probably_damaging	1	neutral	0.24	neutral	3.89	deleterious	-6.33	deleterious	-8.11	high_impact	5.25	0.51	damaging	0.07	damaging	3.90	23.50	deleterious	0.19	0.45	0.86	disease	0.86	disease	0.83	disease	0.82	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.04	medium_impact	3.59	high_impact	0.34	0.8	29.02	7.19	0.54	P	0.97	disease_causing	0.53	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13330	13330	C	T	MI.21374	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	994	332	H	Y	Cac/Tac	-11.28	0	0	probably_damaging	1	neutral	1	neutral	4.25	deleterious	-4.22	deleterious	-5.41	high_impact	4.09	0.46	damaging	0.06	damaging	3.79	23.40	deleterious	0.23	0.45	0.75	disease	0.89	disease	0.75	disease	0.77	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.84	deleterious	-3.6	low_impact	1.89	high_impact	2.53	high_impact	0.44	0.8	29.02	7.19	0.32	N	1.00	polymorphism	0.7	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13331	13331	A	G	MI.21375	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	995	332	H	R	cAc/cGc	5.46	1	0	probably_damaging	1	neutral	0.35	neutral	3.89	deleterious	-6.4	deleterious	-7.21	high_impact	5.25	0.49	damaging	0.07	damaging	3.06	22.40	deleterious	0.21	0.45	0.92	disease	0.9	disease	0.81	disease	0.85	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.08	medium_impact	3.59	high_impact	0.38	0.8	29.02	7.19	0.66	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13331	13331	A	C	MI.21376	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	995	332	H	P	cAc/cCc	5.46	1	0	probably_damaging	1	neutral	0.21	neutral	3.88	deleterious	-7.57	deleterious	-9.01	high_impact	5.25	0.44	damaging	0.08	damaging	3.31	22.90	deleterious	0.18	0.45	0.96	disease	0.88	disease	0.84	disease	0.83	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.09	medium_impact	3.59	high_impact	0.25	0.8	29.02	7.19	0.65	P	0.97	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13331	13331	A	T	MI.21377	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	995	332	H	L	cAc/cTc	5.46	1	0	probably_damaging	1	neutral	0.7	neutral	3.95	deleterious	-5.52	deleterious	-9.91	high_impact	5.25	0.39	damaging	0.08	damaging	3.91	23.50	deleterious	0.16	0.45	0.91	disease	0.91	disease	0.77	disease	0.84	disease	7	1	deleterious	0.35	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.44	medium_impact	3.59	high_impact	0.38	0.8	29.02	7.19	0.73	P	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13332	13332	C	A	MI.21378	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	996	332	H	Q	caC/caA	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	3.97	deleterious	-5.94	deleterious	-7.21	high_impact	5.25	0.45	damaging	0.07	damaging	3.93	23.50	deleterious	0.24	0.45	0.91	disease	0.85	disease	0.78	disease	0.82	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.03	medium_impact	3.59	high_impact	0.39	0.8	29.02	7.19	0.68	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13332	13332	C	G	MI.21379	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	996	332	H	Q	caC/caG	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	3.97	deleterious	-5.94	deleterious	-7.21	high_impact	5.25	0.45	damaging	0.07	damaging	3.59	23.20	deleterious	0.24	0.45	0.91	disease	0.85	disease	0.78	disease	0.82	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.03	medium_impact	3.59	high_impact	0.39	0.8	29.02	7.19	0.67	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6031	6031	A	C	MI.2138	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	128	43	Q	P	cAg/cCg	7.3	1	0	probably_damaging	0.99	deleterious	0.01	neutral	2.99	deleterious	-4.19	deleterious	-2.66	high_impact	4.08	0.54	damaging	0.31	neutral	3.31	22.90	deleterious	0.15	0.55	0.5	neutral	0.87	disease	0.37	neutral	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-0.92	medium_impact	2.67	high_impact	0.40	0.9	2.73	6.75	0.5	P	0.84	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13333	13333	G	A	MI.21380	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	997	333	A	T	Gcc/Acc	-0.73	0.02	0	probably_damaging	1	neutral	0.44	neutral	4.41	deleterious	-4.06	deleterious	-3.6	high_impact	4.76	0.4	damaging	0.11	damaging	4.33	24.00	deleterious	0.2	0.45	0.86	disease	0.85	disease	0.56	disease	0.73	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.18	medium_impact	3.15	high_impact	0.50	0.8	28.19	7.26	0.62	P	0.94	disease_causing	1	0.27	.	.	.	.	.	.	COSM1155534	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13333	13333	G	T	MI.21381	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	997	333	A	S	Gcc/Tcc	-0.73	0.02	0	probably_damaging	1	neutral	0.46	neutral	4.43	neutral	-2.77	deleterious	-2.7	medium_impact	2.35	0.42	damaging	0.19	damaging	3.72	23.30	deleterious	0.2	0.45	0.71	disease	0.79	disease	0.58	disease	0.54	disease	1	1	deleterious	0.23	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.19	medium_impact	0.94	medium_impact	0.61	0.8	28.19	7.26	0.43	N	0.98	disease_causing	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13333	13333	G	C	MI.21382	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	997	333	A	P	Gcc/Ccc	-0.73	0.02	0	probably_damaging	1	neutral	0.22	neutral	4.37	deleterious	-6.69	deleterious	-4.51	high_impact	5.11	0.54	damaging	0.09	damaging	3.88	23.50	deleterious	0.15	0.4	0.94	disease	0.89	disease	0.74	disease	0.83	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.07	medium_impact	3.47	high_impact	0.62	0.8	28.19	7.26	0.63	P	0.96	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13334	13334	C	A	MI.21383	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	998	333	A	D	gCc/gAc	5.92	1	0	probably_damaging	1	neutral	0.2	neutral	4.37	deleterious	-6.84	deleterious	-5.41	high_impact	5.11	0.62	neutral	0.1	damaging	4.59	24.40	deleterious	0.13	0.4	0.92	disease	0.93	disease	0.73	disease	0.83	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.1	medium_impact	3.47	high_impact	0.55	0.8	28.19	7.26	0.72	P	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13334	13334	C	T	MI.21384	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	998	333	A	V	gCc/gTc	5.92	1	0	probably_damaging	1	neutral	0.52	neutral	4.49	deleterious	-3.43	deleterious	-3.6	high_impact	4.55	0.45	damaging	0.06	damaging	4.56	24.40	deleterious	0.27	0.45	0.76	disease	0.87	disease	0.63	disease	0.7	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.25	medium_impact	2.95	high_impact	0.57	0.8	28.19	7.26	0.63	P	0.76	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13334	13334	C	G	MI.21385	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	998	333	A	G	gCc/gGc	5.92	1	0	probably_damaging	1	neutral	0.41	neutral	4.6	neutral	-1.36	deleterious	-3.61	medium_impact	2.54	0.52	damaging	0.13	damaging	4.04	23.70	deleterious	0.19	0.45	0.56	disease	0.85	disease	0.58	disease	0.65	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.15	medium_impact	1.12	medium_impact	0.76	0.85	28.19	7.26	0.48	N	0.82	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13336	13336	T	A	MI.21386	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1000	334	F	I	Ttc/Atc	-10.6	0	0	possibly_damaging	0.81	neutral	0.41	neutral	4.4	neutral	-1.31	deleterious	-5.41	medium_impact	2.92	0.4	damaging	0.59	neutral	4.45	24.20	deleterious	0.21	0.45	0.57	disease	0.88	disease	0.69	disease	0.73	disease	5	0.81	neutral	0.3	neutral	0	NA	0.79	deleterious	-1.34	low_impact	0.15	medium_impact	1.46	medium_impact	0.63	0.8	28.19	7.18	0.57	P	0.95	disease_causing	0.94	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13336	13336	T	G	MI.21387	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1000	334	F	V	Ttc/Gtc	-10.6	0	0	possibly_damaging	0.81	neutral	0.5	neutral	4.46	neutral	-1.64	deleterious	-6.31	medium_impact	3.06	0.35	damaging	0.44	neutral	4.17	23.80	deleterious	0.22	0.45	0.56	disease	0.88	disease	0.7	disease	0.74	disease	5	0.79	neutral	0.35	neutral	0	NA	0.77	deleterious	-1.34	low_impact	0.23	medium_impact	1.59	medium_impact	0.64	0.8	28.19	7.18	0.58	P	0.95	disease_causing	0.97	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13336	13336	T	C	MI.21388	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1000	334	F	L	Ttc/Ctc	-10.6	0	0	benign	0.12	neutral	0.7	neutral	4.59	neutral	-0.05	deleterious	-5.41	medium_impact	2.06	0.25	damaging	0.5	neutral	4.10	23.70	deleterious	0.33	0.5	0.36	neutral	0.81	disease	0.65	disease	0.63	disease	3	0.19	neutral	0.79	deleterious	-3	neutral	0.72	deleterious	0.08	medium_impact	0.44	medium_impact	0.68	medium_impact	0.66	0.8	28.19	7.18	0.86	P	0.92	disease_causing	0.95	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13337	13337	T	G	MI.21389	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1001	334	F	C	tTc/tGc	7.3	1	0	probably_damaging	0.99	neutral	0.21	neutral	4.31	deleterious	-4.98	deleterious	-7.21	high_impact	3.58	0.4	damaging	0.47	neutral	4.14	23.80	deleterious	0.25	0.45	0.89	disease	0.88	disease	0.72	disease	0.81	disease	6	0.99	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-2.64	low_impact	-0.09	medium_impact	2.07	high_impact	0.44	0.8	28.19	7.18	0.71	P	0.99	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6031	6031	A	T	MI.2139	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	128	43	Q	L	cAg/cTg	7.3	1	0	probably_damaging	0.98	deleterious	0.01	neutral	3.05	neutral	-2.73	deleterious	-3.02	medium_impact	2.63	0.61	neutral	0.39	neutral	3.80	23.40	deleterious	0.34	0.55	0.18	neutral	0.75	disease	0.3	neutral	0.59	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.71	deleterious	-2.35	low_impact	-0.92	medium_impact	1.33	medium_impact	0.35	0.9	2.73	6.75	0.54	P	0.71	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13337	13337	T	C	MI.21390	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1001	334	F	S	tTc/tCc	7.3	1	0	probably_damaging	0.97	neutral	0.44	neutral	4.37	deleterious	-4.26	deleterious	-7.2	medium_impact	3.14	0.44	damaging	0.7	neutral	4.26	23.90	deleterious	0.24	0.45	0.82	disease	0.85	disease	0.69	disease	0.71	disease	4	0.97	neutral	0.24	neutral	1	deleterious	0.82	deleterious	-2.18	low_impact	0.18	medium_impact	1.67	medium_impact	0.56	0.8	28.19	7.18	0.66	P	0.97	disease_causing	1	0.19	.	.	.	.	.	.	COSM6716795	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13337	13337	T	A	MI.21391	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1001	334	F	Y	tTc/tAc	7.3	1	0	probably_damaging	0.92	neutral	1	neutral	4.41	deleterious	-3.33	deleterious	-2.7	medium_impact	3.41	0.5	damaging	0.47	neutral	4.24	23.90	deleterious	0.22	0.45	0.77	disease	0.82	disease	0.65	disease	0.64	disease	3	0.92	neutral	0.54	deleterious	1	deleterious	0.81	deleterious	-1.75	low_impact	1.89	high_impact	1.91	medium_impact	0.71	0.85	28.19	7.18	0.56	P	0.88	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13338	13338	C	G	MI.21392	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1002	334	F	L	ttC/ttG	7.3	1	0	benign	0.12	neutral	0.7	neutral	4.59	neutral	-0.05	deleterious	-5.41	medium_impact	2.06	0.25	damaging	0.5	neutral	4.41	24.10	deleterious	0.33	0.5	0.36	neutral	0.81	disease	0.65	disease	0.63	disease	3	0.19	neutral	0.79	deleterious	-3	neutral	0.72	deleterious	0.08	medium_impact	0.44	medium_impact	0.68	medium_impact	0.66	0.8	28.19	7.18	0.94	P	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13338	13338	C	A	MI.21393	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1002	334	F	L	ttC/ttA	7.3	1	0	benign	0.12	neutral	0.7	neutral	4.59	neutral	-0.05	deleterious	-5.41	medium_impact	2.06	0.25	damaging	0.5	neutral	4.71	24.60	deleterious	0.33	0.5	0.36	neutral	0.81	disease	0.65	disease	0.63	disease	3	0.19	neutral	0.79	deleterious	-3	neutral	0.72	deleterious	0.08	medium_impact	0.44	medium_impact	0.68	medium_impact	0.66	0.8	28.19	7.18	0.94	P	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13339	13339	T	A	MI.21394	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1003	335	F	I	Ttc/Atc	-0.27	0.69	0	probably_damaging	1	neutral	0.59	neutral	4.55	neutral	-2.32	deleterious	-5.41	high_impact	4.83	0.4	damaging	0.15	damaging	4.36	24.10	deleterious	0.16	0.45	0.62	disease	0.88	disease	0.69	disease	0.74	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.32	medium_impact	3.21	high_impact	0.54	0.8	26.87	7.22	0.72	P	0.95	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13339	13339	T	C	MI.21395	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1003	335	F	L	Ttc/Ctc	-0.27	0.69	0	probably_damaging	1	neutral	0.89	neutral	4.53	neutral	-2.87	deleterious	-5.41	high_impact	5.17	0.37	damaging	0.12	damaging	4.03	23.70	deleterious	0.32	0.5	0.66	disease	0.81	disease	0.67	disease	0.69	disease	4	1	deleterious	0.45	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.73	medium_impact	3.52	high_impact	0.61	0.8	26.87	7.22	0.68	P	0.92	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13339	13339	T	G	MI.21396	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1003	335	F	V	Ttc/Gtc	-0.27	0.69	0	probably_damaging	1	neutral	0.53	neutral	4.54	neutral	-2.17	deleterious	-6.31	high_impact	4.37	0.34	damaging	0.11	damaging	4.05	23.70	deleterious	0.2	0.45	0.63	disease	0.88	disease	0.7	disease	0.74	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.26	medium_impact	2.79	high_impact	0.53	0.8	26.87	7.22	0.59	P	0.95	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13340	13340	T	G	MI.21397	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1004	335	F	C	tTc/tGc	7.3	1	0	probably_damaging	1	neutral	0.28	neutral	4.43	deleterious	-6.06	deleterious	-7.21	high_impact	5.17	0.44	damaging	0.15	damaging	4.14	23.80	deleterious	0.16	0.45	0.85	disease	0.89	disease	0.72	disease	0.8	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.01	medium_impact	3.52	high_impact	0.38	0.8	26.87	7.22	0.72	P	0.99	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13340	13340	T	A	MI.21398	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1004	335	F	Y	tTc/tAc	7.3	1	0	probably_damaging	1	neutral	1	neutral	4.45	neutral	-2.78	deleterious	-2.7	medium_impact	3.21	0.43	damaging	0.14	damaging	4.29	24.00	deleterious	0.22	0.45	0.77	disease	0.84	disease	0.64	disease	0.71	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.82	deleterious	-3.6	low_impact	1.89	high_impact	1.73	medium_impact	0.64	0.8	26.87	7.22	0.67	P	0.88	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13340	13340	T	C	MI.21399	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1004	335	F	S	tTc/tCc	7.3	1	0	probably_damaging	1	neutral	0.52	neutral	4.55	neutral	-2.7	deleterious	-7.21	high_impact	3.98	0.44	damaging	0.15	damaging	4.30	24.00	deleterious	0.16	0.45	0.73	disease	0.85	disease	0.68	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.25	medium_impact	2.43	high_impact	0.54	0.8	26.87	7.22	0.66	P	0.97	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8626	8626	T	G	MI.214	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	100	34	S	A	Tcc/Gcc	-6.12	0	0	probably_damaging	0.97	neutral	0.81	neutral	4.34	neutral	-0.62	neutral	-1.42	low_impact	1.28	0.89	neutral	0.49	neutral	2.36	18.57	deleterious	0.5	0.65	0.47	neutral	0.33	neutral	0.41	neutral	0.45	neutral	1	0.96	neutral	0.42	neutral	-2	neutral	0.69	deleterious	-2.19	low_impact	0.65	medium_impact	0	medium_impact	0.68	0.9	9.73	14.65	0.24	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6031	6031	A	G	MI.2140	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	128	43	Q	R	cAg/cGg	7.3	1	0	probably_damaging	0.98	neutral	0.16	neutral	2.97	neutral	-2.37	neutral	-1.61	medium_impact	2.23	0.58	damaging	0.33	neutral	3.37	22.90	deleterious	0.6	0.65	0.21	neutral	0.67	disease	0.26	neutral	0.44	neutral	1	0.99	deleterious	0.09	neutral	1	deleterious	0.73	deleterious	-2.35	low_impact	-0.21	medium_impact	0.96	medium_impact	0.52	0.9	2.73	6.75	0.55	P	0.76	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13341	13341	C	G	MI.21400	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1005	335	F	L	ttC/ttG	7.3	1	0	probably_damaging	1	neutral	0.89	neutral	4.53	neutral	-2.87	deleterious	-5.41	high_impact	5.17	0.37	damaging	0.12	damaging	4.41	24.10	deleterious	0.32	0.5	0.66	disease	0.81	disease	0.67	disease	0.69	disease	4	1	deleterious	0.45	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.73	medium_impact	3.52	high_impact	0.61	0.8	26.87	7.22	0.77	P	0.92	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13341	13341	C	A	MI.21401	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1005	335	F	L	ttC/ttA	7.3	1	0	probably_damaging	1	neutral	0.89	neutral	4.53	neutral	-2.87	deleterious	-5.41	high_impact	5.17	0.37	damaging	0.12	damaging	4.72	24.60	deleterious	0.32	0.5	0.66	disease	0.81	disease	0.67	disease	0.69	disease	4	1	deleterious	0.45	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.73	medium_impact	3.52	high_impact	0.61	0.8	26.87	7.22	0.77	P	0.92	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13342	13342	A	C	MI.21402	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1006	336	K	Q	Aaa/Caa	-2.34	0	0	probably_damaging	1	neutral	0.3	neutral	4.41	deleterious	-4.66	deleterious	-3.6	high_impact	5.24	0.47	damaging	0.05	damaging	3.47	23.00	deleterious	0.4	0.5	0.8	disease	0.81	disease	0.71	disease	0.75	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.03	medium_impact	3.58	high_impact	0.70	0.85	29.19	7.25	0.62	P	0.82	disease_causing	0.55	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13342	13342	A	G	MI.21403	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1006	336	K	E	Aaa/Gaa	-2.34	0	0	probably_damaging	1	neutral	0.27	neutral	4.44	deleterious	-4.51	deleterious	-3.6	high_impact	4.89	0.48	damaging	0.06	damaging	4.02	23.60	deleterious	0.32	0.5	0.81	disease	0.82	disease	0.76	disease	0.79	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.01	medium_impact	3.26	high_impact	0.68	0.85	29.19	7.25	0.68	P	0.84	disease_causing	0.67	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13343	13343	A	C	MI.21404	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1007	336	K	T	aAa/aCa	8.44	1	0	probably_damaging	1	neutral	0.43	neutral	4.44	deleterious	-3.45	deleterious	-5.4	high_impact	5.24	0.46	damaging	0.04	damaging	3.72	23.30	deleterious	0.25	0.45	0.81	disease	0.81	disease	0.7	disease	0.73	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.17	medium_impact	3.58	high_impact	0.56	0.8	29.19	7.25	0.68	P	0.75	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13343	13343	A	T	MI.21405	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1007	336	K	M	aAa/aTa	8.44	1	0	probably_damaging	1	neutral	0.24	neutral	4.38	deleterious	-6.16	deleterious	-5.41	high_impact	4.04	0.5	damaging	0.04	damaging	4.01	23.60	deleterious	0.23	0.45	0.89	disease	0.81	disease	0.72	disease	0.78	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.04	medium_impact	2.49	high_impact	0.55	0.8	29.19	7.25	0.53	P	0.40	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13344	13344	A	T	MI.21406	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1008	336	K	N	aaA/aaT	8.44	1	0	probably_damaging	1	neutral	0.32	neutral	4.45	deleterious	-4.19	deleterious	-4.5	high_impact	5.24	0.43	damaging	0.04	damaging	3.94	23.60	deleterious	0.4	0.5	0.86	disease	0.78	disease	0.72	disease	0.77	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.05	medium_impact	3.58	high_impact	0.63	0.8	29.19	7.25	0.75	P	0.63	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13344	13344	A	C	MI.21407	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1008	336	K	N	aaA/aaC	8.44	1	0	probably_damaging	1	neutral	0.32	neutral	4.45	deleterious	-4.19	deleterious	-4.5	high_impact	5.24	0.43	damaging	0.04	damaging	3.83	23.40	deleterious	0.4	0.5	0.86	disease	0.78	disease	0.72	disease	0.77	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.05	medium_impact	3.58	high_impact	0.63	0.8	29.19	7.25	0.75	P	0.63	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13345	13345	G	T	MI.21408	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1009	337	A	S	Gcc/Tcc	2.48	1	0	probably_damaging	1	neutral	0.49	neutral	4.52	neutral	-2.19	deleterious	-2.7	low_impact	1.5	0.4	damaging	0.07	damaging	3.73	23.30	deleterious	0.32	0.5	0.67	disease	0.85	disease	0.62	disease	0.71	disease	4	1	deleterious	0.25	neutral	-2	neutral	0.85	deleterious	-3.6	low_impact	0.22	medium_impact	0.17	medium_impact	0.77	0.85	28.19	7.22	0.59	P	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13345	13345	G	C	MI.21409	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1009	337	A	P	Gcc/Ccc	2.48	1	0	probably_damaging	1	neutral	0.24	neutral	4.35	deleterious	-5.4	deleterious	-4.51	high_impact	5.02	0.43	damaging	0.03	damaging	3.86	23.50	deleterious	0.15	0.4	0.89	disease	0.89	disease	0.76	disease	0.84	disease	7	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.04	medium_impact	3.38	high_impact	0.77	0.85	28.19	7.22	0.69	P	0.96	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6032	6032	G	C	MI.2141	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	129	43	Q	H	caG/caC	7.07	1	0	probably_damaging	1	neutral	0.09	neutral	2.94	deleterious	-3.74	neutral	-1.67	medium_impact	1.94	0.62	neutral	0.55	neutral	2.21	17.60	deleterious	0.6	0.65	0.29	neutral	0.53	disease	0.19	neutral	0.44	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.37	medium_impact	0.69	medium_impact	0.68	0.9	2.73	6.75	0.57	P	0.70	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13345	13345	G	A	MI.21410	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1009	337	A	T	Gcc/Acc	2.48	1	0	probably_damaging	1	neutral	0.48	neutral	4.46	deleterious	-3.22	deleterious	-3.6	high_impact	4.33	0.43	damaging	0.02	damaging	4.36	24.10	deleterious	0.36	0.5	0.73	disease	0.87	disease	0.65	disease	0.7	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.21	medium_impact	2.75	high_impact	0.68	0.85	28.19	7.22	0.58	P	0.94	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13346	13346	C	G	MI.21411	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1010	337	A	G	gCc/gGc	8.9	1	0	probably_damaging	1	neutral	0.36	neutral	4.38	neutral	-2.27	deleterious	-3.61	medium_impact	3.19	0.45	damaging	0.06	damaging	4.03	23.60	deleterious	0.27	0.45	0.74	disease	0.86	disease	0.64	disease	0.7	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.1	medium_impact	1.71	medium_impact	0.77	0.85	28.19	7.22	0.55	P	0.82	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13346	13346	C	T	MI.21412	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1010	337	A	V	gCc/gTc	8.9	1	0	probably_damaging	1	neutral	0.53	neutral	4.51	deleterious	-3.59	deleterious	-3.61	high_impact	4.67	0.4	damaging	0.02	damaging	4.45	24.20	deleterious	0.4	0.5	0.83	disease	0.89	disease	0.65	disease	0.74	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.26	medium_impact	3.06	high_impact	0.75	0.85	28.19	7.22	0.72	P	0.76	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13346	13346	C	A	MI.21413	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1010	337	A	D	gCc/gAc	8.9	1	0	probably_damaging	1	neutral	0.22	neutral	4.35	deleterious	-5.55	deleterious	-5.41	high_impact	5.02	0.46	damaging	0.02	damaging	4.68	24.50	deleterious	0.12	0.4	0.9	disease	0.93	disease	0.75	disease	0.83	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.07	medium_impact	3.38	high_impact	0.68	0.85	28.19	7.22	0.69	P	0.95	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13348	13348	A	T	MI.21414	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1012	338	M	L	Ata/Tta	-16.1	0	0	benign	0.01	neutral	0.84	neutral	4.81	neutral	2.79	deleterious	-2.7	neutral_impact	-0.48	0.7	neutral	0.68	neutral	1.60	13.88	neutral	0.42	0.55	0.42	neutral	0.64	disease	0.63	disease	0.47	neutral	1	0.12	neutral	0.92	deleterious	-6	neutral	0.22	neutral	1.15	medium_impact	0.63	medium_impact	-1.64	low_impact	0.56	0.8	9.78	7.17	0.3	N	0.20	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13348	13348	A	C	MI.21415	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1012	338	M	L	Ata/Cta	-16.1	0	0	benign	0.01	neutral	0.84	neutral	4.81	neutral	2.79	deleterious	-2.7	neutral_impact	-0.48	0.7	neutral	0.68	neutral	1.45	13.06	neutral	0.42	0.55	0.42	neutral	0.64	disease	0.63	disease	0.47	neutral	1	0.12	neutral	0.92	deleterious	-6	neutral	0.22	neutral	1.15	medium_impact	0.63	medium_impact	-1.64	low_impact	0.56	0.8	9.78	7.17	0.3	N	0.20	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13348	13348	A	G	MI.21416	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1012	338	M	V	Ata/Gta	-16.1	0	0	benign	0.36	neutral	0.54	neutral	4.64	neutral	-0.08	deleterious	-3.6	medium_impact	2.42	0.61	neutral	0.39	neutral	1.02	10.79	neutral	0.51	0.6	0.49	neutral	0.88	disease	0.69	disease	0.74	disease	5	0.39	neutral	0.59	deleterious	-3	neutral	0.33	neutral	-0.51	medium_impact	0.27	medium_impact	1.01	medium_impact	0.56	0.8	9.78	7.17	0.26	N	0.76	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13349	13349	T	A	MI.21417	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1013	338	M	K	aTa/aAa	5.46	1	0	possibly_damaging	0.56	neutral	0.33	neutral	4.58	neutral	-2.88	deleterious	-5.41	high_impact	3.87	0.62	neutral	0.39	neutral	2.39	18.75	deleterious	0.19	0.45	0.8	disease	0.95	disease	0.76	disease	0.88	disease	8	0.67	neutral	0.39	neutral	1	deleterious	0.65	deleterious	-0.85	medium_impact	0.06	medium_impact	2.33	high_impact	0.48	0.8	9.78	7.17	0.58	P	0.95	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13349	13349	T	C	MI.21418	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1013	338	M	T	aTa/aCa	5.46	1	0	benign	0.04	neutral	0.42	neutral	4.72	neutral	0.3	deleterious	-5.4	low_impact	1.45	0.58	damaging	0.52	neutral	1.32	12.36	neutral	0.37	0.5	0.48	neutral	0.88	disease	0.65	disease	0.68	disease	4	0.54	neutral	0.69	deleterious	-6	neutral	0.52	deleterious	0.57	medium_impact	0.16	medium_impact	0.12	medium_impact	0.39	0.8	9.78	7.17	0.45	N	0.92	disease_causing	0.99	0.10	.	.	.	.	.	.	COSM6188322	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13350	13350	A	C	MI.21419	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1014	338	M	I	atA/atC	7.3	1	0	benign	0.25	neutral	0.44	neutral	4.68	neutral	-0.39	deleterious	-3.6	medium_impact	2.71	0.6	neutral	0.52	neutral	1.58	13.77	neutral	0.39	0.5	0.63	disease	0.9	disease	0.67	disease	0.74	disease	5	0.47	neutral	0.6	deleterious	-3	neutral	0.37	neutral	-0.29	medium_impact	0.18	medium_impact	1.27	medium_impact	0.61	0.8	9.78	7.17	0.52	P	0.67	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6032	6032	G	T	MI.2142	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	129	43	Q	H	caG/caT	7.07	1	0	probably_damaging	1	neutral	0.09	neutral	2.94	deleterious	-3.74	neutral	-1.67	medium_impact	1.94	0.62	neutral	0.55	neutral	2.34	18.40	deleterious	0.6	0.65	0.29	neutral	0.53	disease	0.19	neutral	0.44	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.37	medium_impact	0.69	medium_impact	0.68	0.9	2.73	6.75	0.56	P	0.70	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13350	13350	A	T	MI.21420	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1014	338	M	I	atA/atT	7.3	1	0	benign	0.25	neutral	0.44	neutral	4.68	neutral	-0.39	deleterious	-3.6	medium_impact	2.71	0.6	neutral	0.52	neutral	1.65	14.11	neutral	0.39	0.5	0.63	disease	0.9	disease	0.67	disease	0.74	disease	5	0.47	neutral	0.6	deleterious	-3	neutral	0.37	neutral	-0.29	medium_impact	0.18	medium_impact	1.27	medium_impact	0.61	0.8	9.78	7.17	0.53	P	0.67	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13351	13351	C	A	MI.21421	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1015	339	L	M	Cta/Ata	-0.27	0	0	possibly_damaging	0.76	neutral	0.47	neutral	4.18	deleterious	-4.39	neutral	-1.72	medium_impact	2.56	0.53	damaging	0.2	damaging	3.72	23.30	deleterious	0.27	0.45	0.74	disease	0.66	disease	0.58	disease	0.59	disease	2	0.75	neutral	0.36	neutral	0	NA	0.78	deleterious	-1.22	low_impact	0.2	medium_impact	1.14	medium_impact	0.70	0.85	17.91	7	0.32	N	0.89	disease_causing	0.52	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13351	13351	C	G	MI.21422	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1015	339	L	V	Cta/Gta	-0.27	0	0	possibly_damaging	0.9	neutral	0.45	neutral	4.2	deleterious	-4.77	deleterious	-2.66	high_impact	5.13	0.45	damaging	0.09	damaging	3.43	23.00	deleterious	0.29	0.45	0.81	disease	0.73	disease	0.66	disease	0.71	disease	4	0.89	neutral	0.28	neutral	1	deleterious	0.82	deleterious	-1.65	low_impact	0.18	medium_impact	3.48	high_impact	0.66	0.8	17.91	7	0.57	P	0.81	disease_causing	0.57	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13352	13352	T	C	MI.21423	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1016	339	L	P	cTa/cCa	-1.65	0	0	probably_damaging	1	neutral	0.17	neutral	4.06	deleterious	-8	deleterious	-6.23	high_impact	4.58	0.49	damaging	0.09	damaging	4.02	23.60	deleterious	0.14	0.4	0.96	disease	0.83	disease	0.77	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.15	medium_impact	2.98	high_impact	0.65	0.8	17.91	7	0.44	N	0.99	disease_causing	1	0.43	.	.	.	.	.	.	COSM1155535	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13352	13352	T	A	MI.21424	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1016	339	L	Q	cTa/cAa	-1.65	0	0	probably_damaging	0.99	neutral	0.2	neutral	4.06	deleterious	-6.73	deleterious	-5.32	high_impact	4.79	0.52	damaging	0.09	damaging	4.28	24.00	deleterious	0.18	0.45	0.89	disease	0.87	disease	0.66	disease	0.77	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-2.64	low_impact	-0.1	medium_impact	3.17	high_impact	0.71	0.85	17.91	7	0.55	P	0.98	disease_causing	0.87	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13352	13352	T	G	MI.21425	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1016	339	L	R	cTa/cGa	-1.65	0	0	probably_damaging	0.99	neutral	0.23	neutral	4.07	deleterious	-7.43	deleterious	-5.33	high_impact	5.13	0.55	damaging	0.08	damaging	4.18	23.80	deleterious	0.15	0.45	0.95	disease	0.92	disease	0.77	disease	0.85	disease	7	0.99	deleterious	0.12	neutral	2	deleterious	0.92	deleterious	-2.64	low_impact	-0.06	medium_impact	3.48	high_impact	0.53	0.8	17.91	7	0.61	P	1.00	disease_causing	0.89	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13354	13354	T	G	MI.21426	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1018	340	F	V	Ttt/Gtt	-2.34	0	0	probably_damaging	1	neutral	0.52	neutral	2.64	deleterious	-7.46	deleterious	-6.31	high_impact	4.2	0.43	damaging	0.04	damaging	3.97	23.60	deleterious	0.2	0.45	0.85	disease	0.89	disease	0.64	disease	0.77	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.25	medium_impact	2.63	high_impact	0.48	0.8	28.19	7.22	0.37	N	0.95	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13354	13354	T	C	MI.21427	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1018	340	F	L	Ttt/Ctt	-2.34	0	0	probably_damaging	1	neutral	0.89	neutral	2.74	deleterious	-5.12	deleterious	-5.41	high_impact	4.54	0.43	damaging	0.03	damaging	3.99	23.60	deleterious	0.21	0.45	0.84	disease	0.82	disease	0.65	disease	0.75	disease	5	1	deleterious	0.45	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.73	medium_impact	2.94	high_impact	0.52	0.8	28.19	7.22	0.45	N	0.92	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13354	13354	T	A	MI.21428	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1018	340	F	I	Ttt/Att	-2.34	0	0	probably_damaging	1	neutral	0.44	neutral	2.65	deleterious	-7.21	deleterious	-5.41	high_impact	4.69	0.43	damaging	0.06	damaging	4.39	24.10	deleterious	0.13	0.4	0.89	disease	0.9	disease	0.67	disease	0.79	disease	6	1	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.18	medium_impact	3.08	high_impact	0.50	0.8	28.19	7.22	0.51	P	0.95	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13355	13355	T	A	MI.21429	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1019	340	F	Y	tTt/tAt	5.69	1	0	probably_damaging	1	neutral	0.95	neutral	2.69	deleterious	-5.93	deleterious	-2.7	high_impact	5.24	0.42	damaging	0.05	damaging	4.36	24.10	deleterious	0.16	0.45	0.93	disease	0.84	disease	0.63	disease	0.8	disease	6	1	deleterious	0.48	deleterious	2	deleterious	0.86	deleterious	-3.6	low_impact	0.94	medium_impact	3.58	high_impact	0.54	0.8	28.19	7.22	0.7	P	0.88	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6033	6033	C	G	MI.2143	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	130	44	P	A	Cca/Gca	-1.03	0	0	probably_damaging	1	deleterious	0.02	neutral	2.4	deleterious	-6.63	deleterious	-3.89	medium_impact	2.78	0.67	neutral	0.07	damaging	2.88	21.80	deleterious	0.33	0.55	0.62	disease	0.69	disease	0.46	neutral	0.52	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-3.58	low_impact	-0.75	medium_impact	1.47	medium_impact	0.79	0.9	2.73	6.72	0.26	N	0.76	disease_causing	0.9	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13355	13355	T	G	MI.21430	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1019	340	F	C	tTt/tGt	5.69	1	0	probably_damaging	1	neutral	0.19	neutral	2.62	deleterious	-10.27	deleterious	-7.21	high_impact	5.24	0.48	damaging	0.04	damaging	4.12	23.80	deleterious	0.17	0.45	0.97	disease	0.89	disease	0.69	disease	0.82	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.12	medium_impact	3.58	high_impact	0.33	0.8	28.19	7.22	0.54	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13355	13355	T	C	MI.21431	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1019	340	F	S	tTt/tCt	5.69	1	0	probably_damaging	1	neutral	0.68	neutral	2.63	deleterious	-9	deleterious	-7.21	high_impact	4.34	0.45	damaging	0.09	damaging	4.33	24.00	deleterious	0.14	0.4	0.94	disease	0.87	disease	0.66	disease	0.81	disease	6	1	deleterious	0.34	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.41	medium_impact	2.76	high_impact	0.42	0.8	28.19	7.22	0.51	P	0.97	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13356	13356	T	A	MI.21432	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1020	340	F	L	ttT/ttA	7.3	1	0.01	probably_damaging	1	neutral	0.89	neutral	2.74	deleterious	-5.12	deleterious	-5.41	high_impact	4.54	0.43	damaging	0.03	damaging	4.50	24.30	deleterious	0.21	0.45	0.84	disease	0.82	disease	0.65	disease	0.75	disease	5	1	deleterious	0.45	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.73	medium_impact	2.94	high_impact	0.52	0.8	28.19	7.22	0.63	P	0.92	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13356	13356	T	G	MI.21433	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1020	340	F	L	ttT/ttG	7.3	1	0.01	probably_damaging	1	neutral	0.89	neutral	2.74	deleterious	-5.12	deleterious	-5.41	high_impact	4.54	0.43	damaging	0.03	damaging	4.39	24.10	deleterious	0.21	0.45	0.84	disease	0.82	disease	0.65	disease	0.75	disease	5	1	deleterious	0.45	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.73	medium_impact	2.94	high_impact	0.52	0.8	28.19	7.22	0.62	P	0.92	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13357	13357	A	G	MI.21434	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1021	341	M	V	Atg/Gtg	-2.57	0	0	benign	0.12	neutral	0.53	neutral	4.68	neutral	-1.66	deleterious	-2.82	medium_impact	2.95	0.7	neutral	0.54	neutral	2.82	21.50	deleterious	0.44	0.55	0.64	disease	0.73	disease	0.68	disease	0.73	disease	5	0.38	neutral	0.71	deleterious	-3	neutral	0.75	deleterious	0.08	medium_impact	0.26	medium_impact	1.49	medium_impact	0.59	0.8	15.59	13.99	0.25	N	0.82	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13357	13357	A	C	MI.21435	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1021	341	M	L	Atg/Ctg	-2.57	0	0	benign	0.01	neutral	0.88	neutral	4.9	neutral	2.24	neutral	-1.41	neutral_impact	-1.03	0.77	neutral	0.96	neutral	0.72	8.93	deleterious	0.4	0.5	0.38	neutral	0.25	neutral	0.41	neutral	0.4	neutral	2	0.08	neutral	0.94	deleterious	-6	neutral	0.58	deleterious	1.15	medium_impact	0.71	medium_impact	-2.14	low_impact	0.66	0.8	15.59	13.99	0.32	N	0.46	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13357	13357	A	T	MI.21436	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1021	341	M	L	Atg/Ttg	-2.57	0	0	benign	0.01	neutral	0.88	neutral	4.9	neutral	2.24	neutral	-1.41	neutral_impact	-1.03	0.77	neutral	0.96	neutral	0.69	8.77	deleterious	0.4	0.5	0.38	neutral	0.25	neutral	0.41	neutral	0.4	neutral	2	0.08	neutral	0.94	deleterious	-6	neutral	0.58	deleterious	1.15	medium_impact	0.71	medium_impact	-2.14	low_impact	0.66	0.8	15.59	13.99	0.32	N	0.46	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13358	13358	T	A	MI.21437	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1022	341	M	K	aTg/aAg	-1.88	0	0	possibly_damaging	0.7	neutral	0.38	neutral	4.55	deleterious	-4.37	deleterious	-4.89	high_impact	3.85	0.68	neutral	0.38	neutral	3.96	23.60	deleterious	0.16	0.45	0.9	disease	0.87	disease	0.76	disease	0.87	disease	7	0.73	neutral	0.34	neutral	1	deleterious	0.88	deleterious	-1.1	low_impact	0.12	medium_impact	2.31	high_impact	0.50	0.8	15.59	13.99	0.4	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13358	13358	T	C	MI.21438	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1022	341	M	T	aTg/aCg	-1.88	0	0	possibly_damaging	0.51	neutral	0.46	neutral	4.59	neutral	-2.57	deleterious	-4.63	high_impact	3.85	0.66	neutral	0.54	neutral	2.94	22.00	deleterious	0.39	0.5	0.79	disease	0.69	disease	0.69	disease	0.77	disease	5	0.54	neutral	0.48	deleterious	1	deleterious	0.83	deleterious	-0.76	medium_impact	0.19	medium_impact	2.31	high_impact	0.46	0.8	15.59	13.99	0.34	N	0.91	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13359	13359	G	C	MI.21439	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1023	341	M	I	atG/atC	4.54	0.65	0.01	benign	0.01	neutral	0.44	neutral	4.72	neutral	-1.21	deleterious	-2.56	low_impact	1.43	0.75	neutral	0.59	neutral	3.53	23.10	deleterious	0.41	0.5	0.61	disease	0.77	disease	0.62	disease	0.72	disease	4	0.55	neutral	0.72	deleterious	-6	neutral	0.79	deleterious	1.15	medium_impact	0.18	medium_impact	0.1	medium_impact	0.62	0.8	15.59	13.99	0.29	N	0.83	polymorphism	0.93	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6033	6033	C	T	MI.2144	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	130	44	P	S	Cca/Tca	-1.03	0	0	probably_damaging	1	deleterious	0.01	neutral	2.39	deleterious	-6.91	deleterious	-3.95	medium_impact	2.3	0.58	damaging	0.06	damaging	3.70	23.30	deleterious	0.51	0.6	0.56	disease	0.77	disease	0.42	neutral	0.55	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-3.58	low_impact	-0.92	medium_impact	1.03	medium_impact	0.24	0.9	2.73	6.72	0.26	N	0.85	disease_causing	0.94	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13359	13359	G	T	MI.21440	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1023	341	M	I	atG/atT	4.54	0.65	0.01	benign	0.01	neutral	0.44	neutral	4.72	neutral	-1.21	deleterious	-2.56	low_impact	1.43	0.75	neutral	0.59	neutral	3.66	23.20	deleterious	0.41	0.5	0.61	disease	0.77	disease	0.62	disease	0.72	disease	4	0.55	neutral	0.72	deleterious	-6	neutral	0.79	deleterious	1.15	medium_impact	0.18	medium_impact	0.1	medium_impact	0.62	0.8	15.59	13.99	0.28	N	0.83	polymorphism	0.93	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13360	13360	T	G	MI.21441	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1024	342	C	G	Tgc/Ggc	-0.96	0.02	0	possibly_damaging	0.73	neutral	0.38	neutral	4.65	neutral	0.98	deleterious	-10.01	low_impact	1.82	0.61	neutral	0.13	damaging	3.30	22.90	deleterious	0.36	0.5	0.38	neutral	0.89	disease	0.75	disease	0.63	disease	3	0.75	neutral	0.33	neutral	-3	neutral	0.79	deleterious	-1.16	low_impact	0.12	medium_impact	0.46	medium_impact	0.63	0.8	8.79	12.49	0.3	N	0.79	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13360	13360	T	C	MI.21442	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1024	342	C	R	Tgc/Cgc	-0.96	0.02	0	probably_damaging	0.95	neutral	0.34	neutral	4.57	neutral	-2.59	deleterious	-10.11	high_impact	4.61	0.62	neutral	0.08	damaging	3.49	23.10	deleterious	0.31	0.45	0.74	disease	0.96	disease	0.84	disease	0.92	disease	8	0.96	neutral	0.2	neutral	2	deleterious	0.92	deleterious	-1.96	low_impact	0.07	medium_impact	3.01	high_impact	0.37	0.8	8.79	12.49	0.57	P	0.89	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13360	13360	T	A	MI.21443	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1024	342	C	S	Tgc/Agc	-0.96	0.02	0	benign	0.12	neutral	0.51	neutral	4.59	neutral	0.23	deleterious	-8.14	low_impact	1.29	0.67	neutral	0.71	neutral	3.45	23.00	deleterious	0.39	0.5	0.5	neutral	0.82	disease	0.7	disease	0.56	disease	1	0.4	neutral	0.7	deleterious	-6	neutral	0.81	deleterious	0.08	medium_impact	0.24	medium_impact	-0.02	medium_impact	0.75	0.85	8.79	12.49	0.31	N	0.45	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13361	13361	G	C	MI.21444	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1025	342	C	S	tGc/tCc	7.3	1	0	benign	0.12	neutral	0.51	neutral	4.59	neutral	0.23	deleterious	-8.14	low_impact	1.29	0.67	neutral	0.71	neutral	3.13	22.60	deleterious	0.39	0.5	0.5	neutral	0.82	disease	0.7	disease	0.56	disease	1	0.4	neutral	0.7	deleterious	-6	neutral	0.81	deleterious	0.08	medium_impact	0.24	medium_impact	-0.02	medium_impact	0.75	0.85	8.79	12.49	0.49	N	0.45	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13361	13361	G	A	MI.21445	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1025	342	C	Y	tGc/tAc	7.3	1	0	probably_damaging	0.98	neutral	1	neutral	4.57	deleterious	-3.04	deleterious	-9.32	high_impact	4.61	0.62	neutral	0.07	damaging	3.63	23.20	deleterious	0.28	0.45	0.79	disease	0.95	disease	0.78	disease	0.89	disease	8	0.98	neutral	0.51	deleterious	2	deleterious	0.89	deleterious	-2.35	low_impact	1.89	high_impact	3.01	high_impact	0.67	0.85	8.79	12.49	0.55	P	0.94	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13361	13361	G	T	MI.21446	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1025	342	C	F	tGc/tTc	7.3	1	0	probably_damaging	0.98	neutral	0.78	neutral	4.65	neutral	-1.82	deleterious	-9.32	high_impact	4.05	0.61	neutral	0.1	damaging	3.98	23.60	deleterious	0.26	0.45	0.79	disease	0.96	disease	0.77	disease	0.88	disease	8	0.97	neutral	0.4	neutral	2	deleterious	0.90	deleterious	-2.35	low_impact	0.54	medium_impact	2.5	high_impact	0.66	0.8	8.79	12.49	0.5	N	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13362	13362	C	A	MI.21447	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1026	342	C	W	tgC/tgA	5.92	1	0	probably_damaging	0.99	neutral	0.18	neutral	4.55	deleterious	-4.57	deleterious	-9.37	high_impact	4.61	0.64	neutral	0.08	damaging	4.59	24.40	deleterious	0.2	0.45	0.93	disease	0.94	disease	0.82	disease	0.87	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-2.64	low_impact	-0.13	medium_impact	3.01	high_impact	0.42	0.8	8.79	12.49	0.59	P	0.96	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13362	13362	C	G	MI.21448	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1026	342	C	W	tgC/tgG	5.92	1	0	probably_damaging	0.99	neutral	0.18	neutral	4.55	deleterious	-4.57	deleterious	-9.37	high_impact	4.61	0.64	neutral	0.08	damaging	4.34	24.00	deleterious	0.2	0.45	0.93	disease	0.94	disease	0.82	disease	0.87	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-2.64	low_impact	-0.13	medium_impact	3.01	high_impact	0.42	0.8	8.79	12.49	0.58	P	0.96	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13363	13363	T	G	MI.21449	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1027	343	S	A	Tcc/Gcc	-0.27	0.35	0	benign	0.07	neutral	0.53	neutral	4.87	neutral	1.93	neutral	-2.26	neutral_impact	-0.2	0.71	neutral	0.46	neutral	2.65	20.50	deleterious	0.4	0.5	0.34	neutral	0.31	neutral	0.52	disease	0.41	neutral	2	0.41	neutral	0.73	deleterious	-6	neutral	0.69	deleterious	0.32	medium_impact	0.26	medium_impact	-1.39	low_impact	0.79	0.85	8.13	14.51	0.3	N	0.49	disease_causing	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6033	6033	C	A	MI.2145	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	130	44	P	T	Cca/Aca	-1.03	0	0	probably_damaging	1	neutral	0.06	neutral	2.36	deleterious	-7.35	deleterious	-3.9	medium_impact	3.01	0.68	neutral	0.05	damaging	3.64	23.20	deleterious	0.39	0.55	0.73	disease	0.8	disease	0.41	neutral	0.58	disease	2	1	deleterious	0.03	neutral	1	deleterious	0.83	deleterious	-3.58	low_impact	-0.47	medium_impact	1.68	medium_impact	0.71	0.9	2.73	6.72	0.27	N	0.80	disease_causing	0.94	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13363	13363	T	A	MI.21450	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1027	343	S	T	Tcc/Acc	-0.27	0.35	0	possibly_damaging	0.7	neutral	0.39	neutral	4.6	neutral	-1.63	deleterious	-2.56	medium_impact	2.67	0.63	neutral	0.08	damaging	3.84	23.40	deleterious	0.35	0.5	0.6	disease	0.77	disease	0.64	disease	0.67	disease	3	0.72	neutral	0.35	neutral	0	NA	0.81	deleterious	-1.1	low_impact	0.13	medium_impact	1.24	medium_impact	0.87	0.9	8.13	14.51	0.21	N	0.71	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13363	13363	T	C	MI.21451	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1027	343	S	P	Tcc/Ccc	-0.27	0.35	0	probably_damaging	0.92	neutral	0.2	neutral	4.56	deleterious	-4.71	deleterious	-4.29	high_impact	4.21	0.63	neutral	0.08	damaging	4.00	23.60	deleterious	0.2	0.45	0.91	disease	0.89	disease	0.81	disease	0.86	disease	7	0.95	neutral	0.14	neutral	2	deleterious	0.89	deleterious	-1.75	low_impact	-0.1	medium_impact	2.64	high_impact	0.79	0.85	8.13	14.51	0.44	N	0.98	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13364	13364	C	A	MI.21452	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1028	343	S	Y	tCc/tAc	3.63	1	0	probably_damaging	0.98	neutral	1	neutral	4.58	deleterious	-3.66	deleterious	-5.19	high_impact	4.21	0.62	neutral	0.08	damaging	4.09	23.70	deleterious	0.16	0.45	0.84	disease	0.9	disease	0.74	disease	0.82	disease	6	0.98	neutral	0.51	deleterious	2	deleterious	0.86	deleterious	-2.35	low_impact	1.89	high_impact	2.64	high_impact	0.75	0.85	8.13	14.51	0.41	N	0.99	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13364	13364	C	G	MI.21453	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1028	343	S	C	tCc/tGc	3.63	1	0	probably_damaging	0.98	neutral	0.19	neutral	4.56	deleterious	-3.64	deleterious	-4.21	medium_impact	3.17	0.63	neutral	0.08	damaging	3.61	23.20	deleterious	0.2	0.45	0.9	disease	0.86	disease	0.64	disease	0.79	disease	6	0.99	deleterious	0.11	neutral	1	deleterious	0.82	deleterious	-2.35	low_impact	-0.12	medium_impact	1.69	medium_impact	0.74	0.85	8.13	14.51	0.38	N	0.99	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13364	13364	C	T	MI.21454	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1028	343	S	F	tCc/tTc	3.63	1	0	probably_damaging	0.98	neutral	0.71	neutral	4.63	neutral	-2.38	deleterious	-5.19	high_impact	4.21	0.59	damaging	0.06	damaging	4.28	24.00	deleterious	0.17	0.45	0.72	disease	0.91	disease	0.72	disease	0.79	disease	6	0.97	neutral	0.37	neutral	2	deleterious	0.86	deleterious	-2.35	low_impact	0.45	medium_impact	2.64	high_impact	0.55	0.8	8.13	14.51	0.4	N	0.99	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13366	13366	G	T	MI.21455	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1030	344	G	W	Ggg/Tgg	-20	0	0	probably_damaging	1	neutral	0.18	neutral	4.32	deleterious	-8.23	deleterious	-7.21	high_impact	5.24	0.6	neutral	0.06	damaging	4.46	24.20	deleterious	0.1	0.4	0.98	disease	0.89	disease	0.79	disease	0.88	disease	8	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.13	medium_impact	3.58	high_impact	0.38	0.8	30.18	7.15	0.5	N	1.00	disease_causing	0.79	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13366	13366	G	C	MI.21456	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1030	344	G	R	Ggg/Cgg	-20	0	0	probably_damaging	1	neutral	0.35	neutral	4.38	deleterious	-6.65	deleterious	-7.21	high_impact	5.24	0.6	damaging	0.06	damaging	4.04	23.70	deleterious	0.09	0.35	0.91	disease	0.9	disease	0.83	disease	0.85	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	0.08	medium_impact	3.58	high_impact	0.69	0.85	30.18	7.15	0.59	P	1.00	disease_causing	0.7	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13367	13367	G	C	MI.21457	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1031	344	G	A	gGg/gCg	8.9	1	0	probably_damaging	1	neutral	0.51	neutral	4.42	deleterious	-4.77	deleterious	-5.4	high_impact	4.34	0.56	damaging	0.12	damaging	3.21	22.70	deleterious	0.19	0.45	0.79	disease	0.73	disease	0.67	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.24	medium_impact	2.76	high_impact	0.65	0.8	30.18	7.15	0.52	P	0.79	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13367	13367	G	A	MI.21458	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1031	344	G	E	gGg/gAg	8.9	1	0	probably_damaging	1	neutral	0.27	neutral	4.45	deleterious	-6.67	deleterious	-7.21	high_impact	5.24	0.56	damaging	0.06	damaging	3.92	23.50	deleterious	0.12	0.4	0.91	disease	0.89	disease	0.82	disease	0.85	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.01	medium_impact	3.58	high_impact	0.59	0.8	30.18	7.15	0.71	P	1.00	disease_causing	1	0.42	.	.	.	.	.	.	COSM1155536	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13367	13367	G	T	MI.21459	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1031	344	G	V	gGg/gTg	8.9	1	0	probably_damaging	1	neutral	0.5	neutral	4.37	deleterious	-5.18	deleterious	-8.11	high_impact	5.24	0.42	damaging	0.06	damaging	3.85	23.40	deleterious	0.11	0.4	0.86	disease	0.89	disease	0.75	disease	0.83	disease	7	1	deleterious	0.25	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.23	medium_impact	3.58	high_impact	0.52	0.8	30.18	7.15	0.67	P	0.98	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6034	6034	C	G	MI.2146	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	131	44	P	R	cCa/cGa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.35	deleterious	-7.9	deleterious	-4.69	high_impact	3.86	0.67	neutral	0.03	damaging	3.43	23.00	deleterious	0.3	0.55	0.89	disease	0.9	disease	0.74	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	2.47	high_impact	0.64	0.9	2.73	6.72	0.46	N	0.90	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13369	13369	T	G	MI.21460	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1033	345	S	A	Tcc/Gcc	-12.2	0	0	probably_damaging	1	neutral	0.54	neutral	4.57	neutral	-0.16	deleterious	-2.55	low_impact	1.25	0.72	neutral	0.42	neutral	3.70	23.30	deleterious	0.49	0.55	0.4	neutral	0.57	disease	0.5	neutral	0.44	neutral	1	1	deleterious	0.27	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.27	medium_impact	-0.06	medium_impact	0.77	0.85	21.23	7.05	0.28	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13369	13369	T	A	MI.21461	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1033	345	S	T	Tcc/Acc	-12.2	0	0	probably_damaging	1	neutral	0.41	neutral	4.56	neutral	-2.08	deleterious	-2.65	medium_impact	2.42	0.6	damaging	0.17	damaging	3.83	23.40	deleterious	0.39	0.5	0.66	disease	0.77	disease	0.62	disease	0.57	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.15	medium_impact	1.01	medium_impact	0.77	0.85	21.23	7.05	0.23	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13369	13369	T	C	MI.21462	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1033	345	S	P	Tcc/Ccc	-12.2	0	0	probably_damaging	1	neutral	0.22	neutral	4.46	deleterious	-5.23	deleterious	-4.43	high_impact	3.88	0.63	neutral	0.11	damaging	3.99	23.60	deleterious	0.19	0.45	0.9	disease	0.89	disease	0.8	disease	0.86	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.07	medium_impact	2.34	high_impact	0.61	0.8	21.23	7.05	0.36	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13370	13370	C	T	MI.21463	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1034	345	S	F	tCc/tTc	2.71	0.88	0	probably_damaging	1	neutral	0.72	neutral	4.51	deleterious	-3.01	deleterious	-5.33	medium_impact	2.4	0.63	neutral	0.09	damaging	4.28	24.00	deleterious	0.19	0.45	0.74	disease	0.9	disease	0.69	disease	0.75	disease	5	1	deleterious	0.36	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.46	medium_impact	0.99	medium_impact	0.43	0.8	21.23	7.05	0.23	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13370	13370	C	G	MI.21464	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1034	345	S	C	tCc/tGc	2.71	0.88	0	probably_damaging	1	neutral	0.2	neutral	4.48	deleterious	-4.27	deleterious	-4.4	medium_impact	2.95	0.65	neutral	0.1	damaging	3.56	23.10	deleterious	0.23	0.45	0.77	disease	0.85	disease	0.67	disease	0.72	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.1	medium_impact	1.49	medium_impact	0.66	0.8	21.23	7.05	0.3	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13370	13370	C	A	MI.21465	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1034	345	S	Y	tCc/tAc	2.71	0.88	0	probably_damaging	1	neutral	1	neutral	4.49	deleterious	-3.28	deleterious	-5.33	medium_impact	2.58	0.64	neutral	0.08	damaging	4.03	23.70	deleterious	0.18	0.45	0.71	disease	0.9	disease	0.71	disease	0.78	disease	6	1	deleterious	0.5	deleterious	1	deleterious	0.85	deleterious	-3.6	low_impact	1.89	high_impact	1.15	medium_impact	0.75	0.85	21.23	7.05	0.22	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13372	13372	A	C	MI.21466	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1036	346	I	L	Atc/Ctc	-8.53	0	0	possibly_damaging	0.49	neutral	0.66	neutral	4.55	neutral	-0.71	neutral	-1.79	low_impact	1.5	0.75	neutral	0.66	neutral	3.83	23.40	deleterious	0.42	0.55	0.49	neutral	0.64	disease	0.61	disease	0.49	neutral	0	0.41	neutral	0.59	deleterious	-3	neutral	0.71	deleterious	-0.73	medium_impact	0.39	medium_impact	0.17	medium_impact	0.81	0.85	18.24	7.26	0.24	N	0.66	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13372	13372	A	T	MI.21467	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1036	346	I	F	Atc/Ttc	-8.53	0	0	probably_damaging	0.94	neutral	0.71	neutral	4.48	neutral	-2.92	deleterious	-3.58	low_impact	1.13	0.77	neutral	0.7	neutral	3.89	23.50	deleterious	0.29	0.45	0.77	disease	0.77	disease	0.67	disease	0.6	disease	2	0.93	neutral	0.39	neutral	-2	neutral	0.81	deleterious	-1.88	low_impact	0.45	medium_impact	-0.17	medium_impact	0.81	0.85	18.24	7.26	0.19	N	0.95	polymorphism	0.65	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13372	13372	A	G	MI.21468	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1036	346	I	V	Atc/Gtc	-8.53	0	0	possibly_damaging	0.62	neutral	0.51	neutral	4.59	neutral	0.63	neutral	-0.89	neutral_impact	0.63	0.83	neutral	0.89	neutral	3.02	22.30	deleterious	0.57	0.65	0.33	neutral	0.25	neutral	0.53	disease	0.42	neutral	2	0.6	neutral	0.45	neutral	-3	neutral	0.64	deleterious	-0.95	medium_impact	0.24	medium_impact	-0.63	medium_impact	0.61	0.8	18.24	7.26	0.33	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13373	13373	T	C	MI.21469	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1037	346	I	T	aTc/aCc	3.83	0.99	0	probably_damaging	0.94	neutral	0.41	neutral	4.43	deleterious	-3.15	deleterious	-4.46	medium_impact	3.45	0.73	neutral	0.43	neutral	3.45	23.00	deleterious	0.36	0.5	0.78	disease	0.82	disease	0.69	disease	0.7	disease	4	0.93	neutral	0.24	neutral	1	deleterious	0.84	deleterious	-1.88	low_impact	0.15	medium_impact	1.95	medium_impact	0.70	0.85	18.24	7.26	0.44	N	0.96	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6034	6034	C	A	MI.2147	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	131	44	P	Q	cCa/cAa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.37	deleterious	-8.2	deleterious	-4.13	high_impact	4.9	0.67	neutral	0.03	damaging	3.88	23.50	deleterious	0.26	0.55	0.89	disease	0.87	disease	0.69	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.43	high_impact	0.64	0.9	2.73	6.72	0.68	P	0.82	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13373	13373	T	A	MI.21470	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1037	346	I	N	aTc/aAc	3.83	0.99	0	probably_damaging	0.98	neutral	0.33	neutral	4.41	deleterious	-5.14	deleterious	-6.25	high_impact	4.34	0.71	neutral	0.38	neutral	4.45	24.20	deleterious	0.25	0.45	0.92	disease	0.85	disease	0.72	disease	0.83	disease	7	0.99	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	0.06	medium_impact	2.76	high_impact	0.77	0.85	18.24	7.26	0.51	P	0.98	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13373	13373	T	G	MI.21471	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1037	346	I	S	aTc/aGc	3.83	0.99	0	probably_damaging	0.94	neutral	0.44	neutral	4.45	deleterious	-3.78	deleterious	-5.34	medium_impact	3.45	0.75	neutral	0.44	neutral	4.32	24.00	deleterious	0.25	0.45	0.74	disease	0.87	disease	0.69	disease	0.73	disease	5	0.93	neutral	0.25	neutral	1	deleterious	0.85	deleterious	-1.88	low_impact	0.18	medium_impact	1.95	medium_impact	0.63	0.8	18.24	7.26	0.47	N	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13374	13374	C	G	MI.21472	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1038	346	I	M	atC/atG	7.27	1	0	possibly_damaging	0.61	neutral	0.22	neutral	4.45	deleterious	-3.16	deleterious	-2.68	medium_impact	1.98	0.81	neutral	0.58	neutral	3.36	22.90	deleterious	0.39	0.5	0.8	disease	0.66	disease	0.63	disease	0.64	disease	3	0.79	neutral	0.31	neutral	0	NA	0.78	deleterious	-0.93	medium_impact	-0.07	medium_impact	0.61	medium_impact	0.85	0.9	18.24	7.26	0.51	N	0.76	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13374	13374	C	A	MI.21473	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1038	346	I	M	atC/atA	7.27	1	0	possibly_damaging	0.61	neutral	0.22	neutral	4.45	deleterious	-3.16	deleterious	-2.68	medium_impact	1.98	0.81	neutral	0.58	neutral	3.88	23.50	deleterious	0.39	0.5	0.8	disease	0.66	disease	0.63	disease	0.64	disease	3	0.79	neutral	0.31	neutral	0	NA	0.78	deleterious	-0.93	medium_impact	-0.07	medium_impact	0.61	medium_impact	0.85	0.9	18.24	7.26	0.51	N	0.76	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13375	13375	A	G	MI.21474	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1039	347	I	V	Atc/Gtc	-4.19	0	0	probably_damaging	1	neutral	0.54	neutral	4.42	neutral	-1.93	neutral	-0.9	high_impact	3.94	0.33	damaging	0.42	neutral	3.10	22.50	deleterious	0.58	0.65	0.57	disease	0.52	disease	0.67	disease	0.66	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.71	deleterious	-3.6	low_impact	0.27	medium_impact	2.4	high_impact	0.70	0.85	28.03	7.24	0.62	P	0.74	disease_causing	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13375	13375	A	T	MI.21475	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1039	347	I	F	Atc/Ttc	-4.19	0	0	probably_damaging	1	neutral	0.76	neutral	4.34	deleterious	-4.16	deleterious	-3.6	high_impact	5.03	0.37	damaging	0.39	neutral	3.80	23.40	deleterious	0.37	0.5	0.88	disease	0.82	disease	0.76	disease	0.82	disease	6	1	deleterious	0.38	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.51	medium_impact	3.39	high_impact	0.84	0.9	28.03	7.24	0.76	P	0.96	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13375	13375	A	C	MI.21476	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1039	347	I	L	Atc/Ctc	-4.19	0	0	probably_damaging	1	neutral	0.94	neutral	4.41	neutral	-1.83	neutral	-1.8	medium_impact	3.4	0.35	damaging	0.46	neutral	3.83	23.40	deleterious	0.36	0.5	0.69	disease	0.67	disease	0.7	disease	0.71	disease	4	1	deleterious	0.47	deleterious	1	deleterious	0.76	deleterious	-3.6	low_impact	0.89	medium_impact	1.9	medium_impact	0.75	0.85	28.03	7.24	0.59	P	0.86	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13376	13376	T	A	MI.21477	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1040	347	I	N	aTc/aAc	8.42	1	0	probably_damaging	1	neutral	0.41	neutral	4.3	deleterious	-5.45	deleterious	-6.31	high_impact	4.68	0.37	damaging	0.46	neutral	4.50	24.30	deleterious	0.29	0.45	0.87	disease	0.83	disease	0.7	disease	0.79	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.15	medium_impact	3.07	high_impact	0.73	0.85	28.03	7.24	0.76	P	0.99	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13376	13376	T	C	MI.21478	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1040	347	I	T	aTc/aCc	8.42	1	0	probably_damaging	1	neutral	0.43	neutral	4.34	deleterious	-3.76	deleterious	-4.5	high_impact	4.48	0.41	damaging	0.43	neutral	3.47	23.00	deleterious	0.43	0.55	0.77	disease	0.83	disease	0.74	disease	0.77	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.17	medium_impact	2.89	high_impact	0.77	0.85	28.03	7.24	0.74	P	0.96	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13376	13376	T	G	MI.21479	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1040	347	I	S	aTc/aGc	8.42	1	0	probably_damaging	1	neutral	0.56	neutral	4.37	deleterious	-3.88	deleterious	-5.4	high_impact	3.79	0.45	damaging	0.51	neutral	4.33	24.00	deleterious	0.32	0.5	0.76	disease	0.86	disease	0.73	disease	0.75	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.29	medium_impact	2.26	high_impact	0.66	0.8	28.03	7.24	0.63	P	0.96	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6034	6034	C	T	MI.2148	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	131	44	P	L	cCa/cTa	7.3	1	0	probably_damaging	1	deleterious	0.01	neutral	2.34	deleterious	-7.75	deleterious	-5.05	high_impact	3.58	0.69	neutral	0.02	damaging	4.26	23.90	deleterious	0.41	0.55	0.89	disease	0.88	disease	0.65	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-0.92	medium_impact	2.21	high_impact	0.73	0.9	2.73	6.72	0.48	N	0.87	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13377	13377	C	G	MI.21480	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1041	347	I	M	atC/atG	5.67	1	0	probably_damaging	1	neutral	0.28	neutral	4.32	deleterious	-3.2	deleterious	-2.7	medium_impact	3.21	0.45	damaging	0.52	neutral	3.44	23.00	deleterious	0.52	0.6	0.84	disease	0.71	disease	0.74	disease	0.79	disease	6	1	deleterious	0.14	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.01	medium_impact	1.73	medium_impact	0.89	0.9	28.03	7.24	0.61	P	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13377	13377	C	A	MI.21481	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1041	347	I	M	atC/atA	5.67	1	0	probably_damaging	1	neutral	0.28	neutral	4.32	deleterious	-3.2	deleterious	-2.7	medium_impact	3.21	0.45	damaging	0.52	neutral	3.88	23.50	deleterious	0.52	0.6	0.84	disease	0.71	disease	0.74	disease	0.79	disease	6	1	deleterious	0.14	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.01	medium_impact	1.73	medium_impact	0.89	0.9	28.03	7.24	0.61	P	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13378	13378	C	G	MI.21482	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1042	348	H	D	Cac/Gac	-4.19	0	0	probably_damaging	1	neutral	0.22	neutral	4.61	neutral	-2.82	deleterious	-8.11	high_impact	4.42	0.5	damaging	0.1	damaging	3.94	23.50	deleterious	0.16	0.45	0.6	disease	0.88	disease	0.85	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.07	medium_impact	2.83	high_impact	0.49	0.8	28.52	7.26	0.55	P	0.97	disease_causing	0.61	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13378	13378	C	A	MI.21483	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1042	348	H	N	Cac/Aac	-4.19	0	0	probably_damaging	1	neutral	0.42	neutral	4.55	deleterious	-3.61	deleterious	-6.31	high_impact	4.14	0.36	damaging	0.1	damaging	3.95	23.60	deleterious	0.42	0.55	0.73	disease	0.86	disease	0.8	disease	0.78	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.16	medium_impact	2.58	high_impact	0.45	0.8	28.52	7.26	0.54	P	0.97	polymorphism	0.68	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13378	13378	C	T	MI.21484	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1042	348	H	Y	Cac/Tac	-4.19	0	0	probably_damaging	1	neutral	1	neutral	4.55	neutral	-1.69	deleterious	-5.41	high_impact	3.62	0.43	damaging	0.09	damaging	3.77	23.40	deleterious	0.47	0.55	0.78	disease	0.9	disease	0.76	disease	0.79	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.87	deleterious	-3.6	low_impact	1.89	high_impact	2.1	high_impact	0.51	0.8	28.52	7.26	0.37	N	1.00	polymorphism	0.63	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13379	13379	A	T	MI.21485	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1043	348	H	L	cAc/cTc	5.44	1	0	probably_damaging	1	neutral	0.78	neutral	4.55	neutral	-2.84	deleterious	-9.91	high_impact	3.54	0.35	damaging	0.09	damaging	3.96	23.60	deleterious	0.17	0.45	0.68	disease	0.92	disease	0.8	disease	0.82	disease	6	1	deleterious	0.39	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.54	medium_impact	2.03	high_impact	0.35	0.8	28.52	7.26	0.67	P	0.97	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13379	13379	A	G	MI.21486	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1043	348	H	R	cAc/cGc	5.44	1	0	probably_damaging	1	neutral	0.35	neutral	4.54	neutral	-2.63	deleterious	-7.21	high_impact	3.8	0.48	damaging	0.1	damaging	3.05	22.40	deleterious	0.39	0.5	0.69	disease	0.89	disease	0.82	disease	0.82	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.08	medium_impact	2.27	high_impact	0.54	0.8	28.52	7.26	0.56	P	0.99	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13379	13379	A	C	MI.21487	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1043	348	H	P	cAc/cCc	5.44	1	0	probably_damaging	1	neutral	0.21	neutral	4.49	deleterious	-4.94	deleterious	-9.01	high_impact	4.57	0.41	damaging	0.11	damaging	3.28	22.80	deleterious	0.15	0.4	0.86	disease	0.92	disease	0.87	disease	0.85	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.09	medium_impact	2.97	high_impact	0.28	0.8	28.52	7.26	0.8	P	0.97	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	A13379C	LHON	+	-	Reported	1	.	P	P	damaging
chrM	13380	13380	C	G	MI.21488	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1044	348	H	Q	caC/caG	8.42	1	0	probably_damaging	1	neutral	0.31	neutral	4.56	neutral	-2.84	deleterious	-7.21	high_impact	4.42	0.44	damaging	0.11	damaging	3.60	23.20	deleterious	0.49	0.55	0.71	disease	0.87	disease	0.8	disease	0.79	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.04	medium_impact	2.83	high_impact	0.64	0.8	28.52	7.26	0.7	P	0.95	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13380	13380	C	A	MI.21489	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1044	348	H	Q	caC/caA	8.42	1	0	probably_damaging	1	neutral	0.31	neutral	4.56	neutral	-2.84	deleterious	-7.21	high_impact	4.42	0.44	damaging	0.11	damaging	3.97	23.60	deleterious	0.49	0.55	0.71	disease	0.87	disease	0.8	disease	0.79	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.04	medium_impact	2.83	high_impact	0.64	0.8	28.52	7.26	0.71	P	0.95	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6036	6036	G	T	MI.2149	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	133	45	G	C	Ggc/Tgc	-14.91	0	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-5.66	deleterious	-5.31	high_impact	4.96	0.42	damaging	0.02	damaging	4.04	23.70	deleterious	0.22	0.55	0.96	disease	0.93	disease	0.65	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.41	0.9	3.9	6.63	0.5	N	0.98	polymorphism	0.72	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13381	13381	A	T	MI.21490	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1045	349	N	Y	Aac/Tac	-2.58	0	0	probably_damaging	0.99	neutral	1	neutral	4.46	deleterious	-3.58	deleterious	-5.1	low_impact	1.93	0.76	neutral	0.57	neutral	3.61	23.20	deleterious	0.54	0.6	0.85	disease	0.79	disease	0.65	disease	0.78	disease	6	0.99	deleterious	0.51	deleterious	-2	neutral	0.84	deleterious	-2.64	low_impact	1.89	high_impact	0.56	medium_impact	0.44	0.8	2.82	9.78	0.18	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13381	13381	A	G	MI.21491	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1045	349	N	D	Aac/Gac	-2.58	0	0	possibly_damaging	0.86	neutral	0.25	neutral	4.49	neutral	-1.92	deleterious	-2.82	medium_impact	2.34	0.72	neutral	0.52	neutral	3.80	23.40	deleterious	0.77	0.8	0.6	disease	0.66	disease	0.67	disease	0.71	disease	4	0.9	neutral	0.2	neutral	0	NA	0.78	deleterious	-1.5	low_impact	-0.03	medium_impact	0.94	medium_impact	0.57	0.8	2.82	9.78	0.3	N	0.63	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13381	13381	A	C	MI.21492	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1045	349	N	H	Aac/Cac	-2.58	0	0	probably_damaging	0.99	neutral	0.57	neutral	4.47	neutral	-2.92	deleterious	-3.24	medium_impact	3	0.82	neutral	0.57	neutral	3.07	22.40	deleterious	0.64	0.7	0.77	disease	0.65	disease	0.7	disease	0.75	disease	5	0.99	deleterious	0.29	neutral	1	deleterious	0.80	deleterious	-2.64	low_impact	0.3	medium_impact	1.54	medium_impact	0.53	0.8	2.82	9.78	0.21	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13382	13382	A	G	MI.21493	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1046	349	N	S	aAc/aGc	6.81	0.82	0	benign	0.18	neutral	0.51	neutral	4.55	neutral	-0.88	neutral	-1.13	neutral_impact	-0.1	0.83	neutral	0.99	neutral	0.95	10.36	neutral	0.73	0.75	0.31	neutral	0.13	neutral	0.24	neutral	0.25	neutral	5	0.39	neutral	0.67	deleterious	-6	neutral	0.68	deleterious	-0.12	medium_impact	0.24	medium_impact	-1.29	low_impact	0.25	0.8	2.82	9.78	0.5	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13382	13382	A	C	MI.21494	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1046	349	N	T	aAc/aCc	6.81	0.82	0	possibly_damaging	0.81	neutral	0.42	neutral	4.5	neutral	-1.78	deleterious	-2.87	low_impact	1.73	0.78	neutral	0.79	neutral	3.90	23.50	deleterious	0.58	0.65	0.57	disease	0.68	disease	0.59	disease	0.66	disease	3	0.81	neutral	0.31	neutral	-3	neutral	0.77	deleterious	-1.34	low_impact	0.16	medium_impact	0.38	medium_impact	0.50	0.8	2.82	9.78	0.4	N	0.34	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13382	13382	A	T	MI.21495	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1046	349	N	I	aAc/aTc	6.81	0.82	0	probably_damaging	0.98	neutral	0.43	neutral	4.48	neutral	-2.2	deleterious	-5.58	medium_impact	2.49	0.76	neutral	0.61	neutral	4.48	24.20	deleterious	0.56	0.6	0.62	disease	0.82	disease	0.6	disease	0.75	disease	5	0.98	neutral	0.23	neutral	1	deleterious	0.81	deleterious	-2.35	low_impact	0.17	medium_impact	1.07	medium_impact	0.32	0.8	2.82	9.78	0.39	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13383	13383	C	G	MI.21496	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1047	349	N	K	aaC/aaG	-0.75	0	0	possibly_damaging	0.88	neutral	0.34	neutral	4.55	neutral	-0.86	deleterious	-3.3	medium_impact	2.25	0.74	neutral	0.6	neutral	4.08	23.70	deleterious	0.76	0.8	0.42	neutral	0.79	disease	0.72	disease	0.76	disease	5	0.89	neutral	0.23	neutral	0	NA	0.78	deleterious	-1.57	low_impact	0.07	medium_impact	0.85	medium_impact	0.57	0.8	2.82	9.78	0.32	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13383	13383	C	A	MI.21497	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1047	349	N	K	aaC/aaA	-0.75	0	0	possibly_damaging	0.88	neutral	0.34	neutral	4.55	neutral	-0.86	deleterious	-3.3	medium_impact	2.25	0.74	neutral	0.6	neutral	4.55	24.40	deleterious	0.76	0.8	0.42	neutral	0.79	disease	0.72	disease	0.76	disease	5	0.89	neutral	0.23	neutral	0	NA	0.78	deleterious	-1.57	low_impact	0.07	medium_impact	0.85	medium_impact	0.57	0.8	2.82	9.78	0.31	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13384	13384	C	A	MI.21498	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1048	350	L	I	Ctt/Att	-0.29	0	0	probably_damaging	1	neutral	0.42	neutral	4.62	neutral	-1.24	neutral	-1.8	medium_impact	2.4	0.58	damaging	0.08	damaging	4.34	24.00	deleterious	0.6	0.65	NA	NA	0.78	disease	0.52	disease	0.6	disease	2	1	deleterious	0.21	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.16	medium_impact	0.99	medium_impact	0.62	0.8	23.05	7.06	0.23	N	0.85	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13384	13384	C	G	MI.21499	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1048	350	L	V	Ctt/Gtt	-0.29	0	0	probably_damaging	1	neutral	0.53	neutral	4.64	neutral	-0.21	deleterious	-2.7	low_impact	1.84	0.56	damaging	0.09	damaging	3.50	23.10	deleterious	0.63	0.65	NA	NA	0.67	disease	0.65	disease	0.5	disease	0	1	deleterious	0.27	neutral	-2	neutral	0.84	deleterious	-3.6	low_impact	0.26	medium_impact	0.48	medium_impact	0.43	0.8	23.05	7.06	0.18	N	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8627	8627	C	A	MI.215	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	101	34	S	Y	tCc/tAc	0.59	0	0	probably_damaging	1	neutral	0.96	neutral	4.28	neutral	-2.08	deleterious	-3.56	low_impact	1.69	0.86	neutral	0.17	damaging	3.92	23.50	deleterious	0.38	0.65	0.77	disease	0.71	disease	0.63	disease	0.73	disease	5	1	deleterious	0.48	deleterious	-2	neutral	0.78	deleterious	-3.6	low_impact	1.07	medium_impact	0.35	medium_impact	0.52	0.9	9.73	14.65	0.17	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6036	6036	G	A	MI.2150	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	133	45	G	S	Ggc/Agc	-14.91	0	0	probably_damaging	1	neutral	0.09	neutral	2.79	neutral	-1.35	deleterious	-3.4	medium_impact	2.55	0.49	damaging	0.05	damaging	4.01	23.60	deleterious	0.31	0.55	0.56	disease	0.85	disease	0.54	disease	0.52	disease	0	1	deleterious	0.05	neutral	1	deleterious	0.84	deleterious	-3.58	low_impact	-0.37	medium_impact	1.26	medium_impact	0.65	0.9	3.9	6.63	0.27	N	0.73	polymorphism	0.91	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13384	13384	C	T	MI.21500	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1048	350	L	F	Ctt/Ttt	-0.29	0	0	probably_damaging	1	neutral	0.71	neutral	4.6	neutral	-2.42	deleterious	-3.6	low_impact	1.45	0.56	damaging	0.06	damaging	4.05	23.70	deleterious	0.56	0.6	NA	NA	0.79	disease	0.54	disease	0.61	disease	2	1	deleterious	0.36	neutral	-2	neutral	0.87	deleterious	-3.6	low_impact	0.45	medium_impact	0.12	medium_impact	0.51	0.8	23.05	7.06	0.15	N	0.99	polymorphism	1	0.06	rs28371809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13385	13385	T	C	MI.21501	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1049	350	L	P	cTt/cCt	-0.06	0	0	probably_damaging	1	neutral	0.23	neutral	4.56	deleterious	-3.79	deleterious	-6.3	high_impact	4.2	0.54	damaging	0.03	damaging	3.91	23.50	deleterious	0.22	0.45	NA	NA	0.89	disease	0.63	disease	0.72	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	-0.06	medium_impact	2.63	high_impact	0.52	0.8	23.05	7.06	0.31	N	0.99	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13385	13385	T	A	MI.21502	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1049	350	L	H	cTt/cAt	-0.06	0	0	probably_damaging	1	neutral	0.55	neutral	4.59	deleterious	-3.83	deleterious	-6.3	medium_impact	2.92	0.55	damaging	0.03	damaging	4.15	23.80	deleterious	0.39	0.5	NA	NA	0.88	disease	0.69	disease	0.74	disease	5	1	deleterious	0.28	neutral	1	deleterious	0.91	deleterious	-3.6	low_impact	0.28	medium_impact	1.46	medium_impact	0.58	0.8	23.05	7.06	0.21	N	0.97	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13385	13385	T	G	MI.21503	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1049	350	L	R	cTt/cGt	-0.06	0	0	probably_damaging	1	neutral	0.4	neutral	4.58	neutral	-0.55	deleterious	-5.4	high_impact	3.5	0.58	damaging	0.03	damaging	4.22	23.90	deleterious	0.33	0.5	NA	NA	0.92	disease	0.71	disease	0.78	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.94	deleterious	-3.6	low_impact	0.14	medium_impact	1.99	medium_impact	0.75	0.85	23.05	7.06	0.24	N	1.00	polymorphism	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13387	13387	A	C	MI.21504	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1051	351	N	H	Aac/Cac	-5.1	0	0	probably_damaging	0.98	neutral	0.56	neutral	4.61	neutral	1.33	deleterious	-4.26	low_impact	1.16	0.69	neutral	0.49	neutral	3.08	22.50	deleterious	0.79	0.8	0.56	disease	0.83	disease	0.59	disease	0.57	disease	1	0.97	neutral	0.29	neutral	-2	neutral	0.79	deleterious	-2.35	low_impact	0.29	medium_impact	-0.14	medium_impact	0.46	0.8	4.15	9.29	0.23	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13387	13387	A	T	MI.21505	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1051	351	N	Y	Aac/Tac	-5.1	0	0	probably_damaging	0.98	neutral	1	neutral	4.54	neutral	-1.71	deleterious	-6.84	medium_impact	2.37	0.73	neutral	0.39	neutral	3.73	23.30	deleterious	0.62	0.65	0.68	disease	0.92	disease	0.67	disease	0.75	disease	5	0.98	deleterious	0.51	deleterious	1	deleterious	0.84	deleterious	-2.35	low_impact	1.89	high_impact	0.96	medium_impact	0.48	0.8	4.15	9.29	0.17	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13387	13387	A	G	MI.21506	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1051	351	N	D	Aac/Gac	-5.1	0	0	benign	0.12	neutral	0.3	neutral	4.57	neutral	-0.55	deleterious	-3.94	low_impact	1.82	0.77	neutral	0.74	neutral	2.28	18.03	deleterious	0.82	0.85	0.63	disease	0.79	disease	0.44	neutral	0.54	disease	1	0.65	neutral	0.59	deleterious	-6	neutral	0.61	deleterious	0.08	medium_impact	0.03	medium_impact	0.46	medium_impact	0.52	0.8	4.15	9.29	0.29	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13388	13388	A	T	MI.21507	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1052	351	N	I	aAc/aTc	2.69	0.12	0	probably_damaging	0.96	neutral	0.42	neutral	4.56	neutral	-2.39	deleterious	-7.7	medium_impact	2.82	0.7	neutral	0.52	neutral	3.84	23.40	deleterious	0.62	0.65	0.65	disease	0.93	disease	0.62	disease	0.74	disease	5	0.96	neutral	0.23	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	0.16	medium_impact	1.37	medium_impact	0.33	0.8	4.15	9.29	0.37	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13388	13388	A	G	MI.21508	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1052	351	N	S	aAc/aGc	2.69	0.12	0	benign	0.2	neutral	0.52	neutral	4.62	neutral	0.14	deleterious	-4.13	low_impact	0.94	0.76	neutral	0.78	neutral	1.24	11.93	neutral	0.84	0.85	0.46	neutral	0.77	disease	0.41	neutral	0.52	disease	0	0.38	neutral	0.66	deleterious	-6	neutral	0.29	neutral	-0.17	medium_impact	0.25	medium_impact	-0.34	medium_impact	0.22	0.8	4.15	9.29	0.3	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13388	13388	A	C	MI.21509	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1052	351	N	T	aAc/aCc	2.69	0.12	0	possibly_damaging	0.74	neutral	0.47	neutral	4.57	neutral	1.04	deleterious	-5.08	medium_impact	2.48	0.7	neutral	0.54	neutral	1.88	15.46	deleterious	0.73	0.75	0.34	neutral	0.89	disease	0.54	disease	0.66	disease	3	0.73	neutral	0.37	neutral	0	NA	0.54	deleterious	-1.18	low_impact	0.2	medium_impact	1.06	medium_impact	0.41	0.8	4.15	9.29	0.34	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6036	6036	G	C	MI.2151	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	133	45	G	R	Ggc/Cgc	-14.91	0	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-3.01	deleterious	-4.64	high_impact	4.62	0.46	damaging	0.02	damaging	3.86	23.50	deleterious	0.29	0.55	0.77	disease	0.93	disease	0.72	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.78	0.9	3.9	6.63	0.46	N	0.95	polymorphism	0.83	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13389	13389	C	G	MI.21510	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1053	351	N	K	aaC/aaG	2	0.11	0	possibly_damaging	0.83	neutral	0.42	neutral	4.67	neutral	0.02	deleterious	-5.08	low_impact	1.36	0.73	neutral	0.55	neutral	2.38	18.69	deleterious	0.81	0.85	0.61	disease	0.9	disease	0.58	disease	0.57	disease	1	0.83	neutral	0.3	neutral	-3	neutral	0.69	deleterious	-1.4	low_impact	0.16	medium_impact	0.04	medium_impact	0.51	0.8	4.15	9.29	0.3	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13389	13389	C	A	MI.21511	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1053	351	N	K	aaC/aaA	2	0.11	0	possibly_damaging	0.83	neutral	0.42	neutral	4.67	neutral	0.02	deleterious	-5.08	low_impact	1.36	0.73	neutral	0.55	neutral	2.86	21.70	deleterious	0.81	0.85	0.61	disease	0.9	disease	0.58	disease	0.57	disease	1	0.83	neutral	0.3	neutral	-3	neutral	0.69	deleterious	-1.4	low_impact	0.16	medium_impact	0.04	medium_impact	0.51	0.8	4.15	9.29	0.3	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13390	13390	A	T	MI.21512	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1054	352	N	Y	Aat/Tat	-8.31	0	0	probably_damaging	1	neutral	1	neutral	3.7	deleterious	-3.09	deleterious	-5.32	high_impact	4.05	0.74	neutral	0.55	neutral	3.58	23.20	deleterious	0.41	0.5	0.84	disease	0.85	disease	0.71	disease	0.8	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.86	deleterious	-3.6	low_impact	1.89	high_impact	2.5	high_impact	0.47	0.8	10.45	13	0.27	N	0.90	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13390	13390	A	G	MI.21513	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1054	352	N	D	Aat/Gat	-8.31	0	0	probably_damaging	1	neutral	0.26	neutral	3.87	neutral	0.49	neutral	0.2	neutral_impact	0.18	0.77	neutral	0.98	neutral	0.99	10.63	neutral	0.83	0.85	0.32	neutral	0.14	neutral	0.35	neutral	0.22	neutral	6	1	deleterious	0.13	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	-0.02	medium_impact	-1.04	low_impact	0.59	0.8	10.45	13	0.43	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13390	13390	A	C	MI.21514	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1054	352	N	H	Aat/Cat	-8.31	0	0	probably_damaging	1	neutral	0.55	neutral	3.85	neutral	1.33	deleterious	-3.09	low_impact	1.8	0.76	neutral	0.51	neutral	3.01	22.30	deleterious	0.79	0.8	0.34	neutral	0.69	disease	0.71	disease	0.59	disease	2	1	deleterious	0.28	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.28	medium_impact	0.44	medium_impact	0.59	0.8	10.45	13	0.27	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13391	13391	A	G	MI.21515	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1055	352	N	S	aAt/aGt	0.4	0.2	0	probably_damaging	1	neutral	0.46	neutral	3.83	neutral	0.55	deleterious	-2.62	low_impact	1.93	0.74	neutral	0.6	neutral	3.24	22.80	deleterious	0.86	0.9	0.45	neutral	0.72	disease	0.6	disease	0.69	disease	4	1	deleterious	0.23	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.19	medium_impact	0.56	medium_impact	0.31	0.8	10.45	13	0.26	N	0.39	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13391	13391	A	C	MI.21516	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1055	352	N	T	aAt/aCt	0.4	0.2	0	probably_damaging	1	neutral	0.43	neutral	3.82	neutral	0.45	deleterious	-3.52	medium_impact	2.54	0.7	neutral	0.58	neutral	3.60	23.20	deleterious	0.71	0.75	0.57	disease	0.77	disease	0.68	disease	0.74	disease	5	1	deleterious	0.22	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.17	medium_impact	1.12	medium_impact	0.56	0.8	10.45	13	0.25	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13391	13391	A	T	MI.21517	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1055	352	N	I	aAt/aTt	0.4	0.2	0	probably_damaging	1	neutral	0.44	neutral	3.7	neutral	-2.2	deleterious	-5.75	medium_impact	2.9	0.72	neutral	0.51	neutral	4.11	23.70	deleterious	0.38	0.5	0.71	disease	0.87	disease	0.69	disease	0.78	disease	6	1	deleterious	0.22	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.18	medium_impact	1.45	medium_impact	0.36	0.8	10.45	13	0.25	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13392	13392	T	A	MI.21518	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1056	352	N	K	aaT/aaA	5.67	0.72	0	probably_damaging	1	neutral	0.35	neutral	3.81	neutral	0.01	deleterious	-3.52	medium_impact	3.16	0.71	neutral	0.44	neutral	4.36	24.10	deleterious	0.78	0.8	0.35	neutral	0.84	disease	0.69	disease	0.77	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.08	medium_impact	1.68	medium_impact	0.65	0.8	10.45	13	0.45	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13392	13392	T	G	MI.21519	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1056	352	N	K	aaT/aaG	5.67	0.72	0	probably_damaging	1	neutral	0.35	neutral	3.81	neutral	0.01	deleterious	-3.52	medium_impact	3.16	0.71	neutral	0.44	neutral	4.05	23.70	deleterious	0.78	0.8	0.35	neutral	0.84	disease	0.69	disease	0.77	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.08	medium_impact	1.68	medium_impact	0.65	0.8	10.45	13	0.44	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6037	6037	G	C	MI.2152	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	134	45	G	A	gGc/gCc	4.29	1	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.17	deleterious	-3.5	high_impact	3.82	0.58	damaging	0.05	damaging	3.02	22.30	deleterious	0.35	0.55	0.68	disease	0.83	disease	0.63	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.43	high_impact	0.60	0.9	3.9	6.63	0.41	N	0.64	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13393	13393	G	A	MI.21520	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1057	353	E	K	Gaa/Aaa	-4.19	0	0	probably_damaging	1	neutral	0.94	neutral	4.67	neutral	-1.5	deleterious	-3.6	medium_impact	3.23	0.41	damaging	0.13	damaging	4.58	24.40	deleterious	0.65	0.7	0.54	disease	0.94	disease	0.78	disease	0.87	disease	7	1	deleterious	0.47	deleterious	1	deleterious	0.87	deleterious	-3.6	low_impact	0.89	medium_impact	1.75	medium_impact	0.77	0.85	28.69	7.2	0.5	N	0.99	polymorphism	0.74	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13393	13393	G	C	MI.21521	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1057	353	E	Q	Gaa/Caa	-4.19	0	0	probably_damaging	1	neutral	0.69	neutral	4.58	neutral	-2.31	deleterious	-2.7	medium_impact	2.9	0.39	damaging	0.16	damaging	3.42	23.00	deleterious	0.76	0.8	0.66	disease	0.85	disease	0.74	disease	0.77	disease	5	1	deleterious	0.35	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.42	medium_impact	1.45	medium_impact	0.75	0.85	28.69	7.2	0.44	N	0.89	polymorphism	0.93	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13394	13394	A	G	MI.21522	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1058	353	E	G	gAa/gGa	5.9	1	0	probably_damaging	1	neutral	0.59	neutral	4.54	neutral	-2.82	deleterious	-6.29	medium_impact	3.37	0.29	damaging	0.17	damaging	4.38	24.10	deleterious	0.67	0.7	0.82	disease	0.83	disease	0.75	disease	0.8	disease	6	1	deleterious	0.3	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.32	medium_impact	1.88	medium_impact	0.51	0.8	28.69	7.2	0.88	P	0.51	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13394	13394	A	C	MI.21523	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1058	353	E	A	gAa/gCa	5.9	1	0	probably_damaging	1	neutral	1	neutral	4.6	neutral	-1.79	deleterious	-5.39	medium_impact	3.02	0.35	damaging	0.16	damaging	3.80	23.40	deleterious	0.67	0.7	0.68	disease	0.85	disease	0.76	disease	0.78	disease	6	1	deleterious	0.5	deleterious	1	deleterious	0.84	deleterious	-3.6	low_impact	1.89	high_impact	1.56	medium_impact	0.72	0.85	28.69	7.2	0.68	P	0.75	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13394	13394	A	T	MI.21524	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1058	353	E	V	gAa/gTa	5.9	1	0	probably_damaging	1	neutral	0.63	neutral	4.6	neutral	-2.98	deleterious	-6.29	medium_impact	2.94	0.33	damaging	0.14	damaging	4.28	24.00	deleterious	0.54	0.6	0.66	disease	0.93	disease	0.77	disease	0.81	disease	6	1	deleterious	0.32	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.36	medium_impact	1.48	medium_impact	0.68	0.85	28.69	7.2	0.69	P	0.81	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13395	13395	A	T	MI.21525	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1059	353	E	D	gaA/gaT	8.42	1	0.01	probably_damaging	1	neutral	0.65	neutral	4.55	neutral	-2.2	deleterious	-2.7	medium_impact	2.77	0.47	damaging	0.14	damaging	3.84	23.40	deleterious	0.62	0.65	0.72	disease	0.81	disease	0.7	disease	0.71	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.38	medium_impact	1.33	medium_impact	0.75	0.85	28.69	7.2	0.6	P	0.86	disease_causing	1	0.07	rs386829179	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13395	13395	A	C	MI.21526	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1059	353	E	D	gaA/gaC	8.42	1	0.01	probably_damaging	1	neutral	0.65	neutral	4.55	neutral	-2.2	deleterious	-2.7	medium_impact	2.77	0.47	damaging	0.14	damaging	3.75	23.30	deleterious	0.62	0.65	0.72	disease	0.81	disease	0.7	disease	0.71	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.38	medium_impact	1.33	medium_impact	0.75	0.85	28.69	7.2	0.59	P	0.86	disease_causing	1	0.07	rs386829179	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13396	13396	C	G	MI.21527	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1060	354	Q	E	Caa/Gaa	-0.06	0.79	0	probably_damaging	1	neutral	1	neutral	4.51	neutral	-1.31	deleterious	-2.7	high_impact	4.36	0.43	damaging	0.05	damaging	3.12	22.60	deleterious	0.47	0.55	0.66	disease	0.84	disease	0.68	disease	0.71	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.6	low_impact	1.89	high_impact	2.78	high_impact	0.58	0.8	28.69	7.17	0.45	N	0.92	disease_causing	0.99	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13396	13396	C	A	MI.21528	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1060	354	Q	K	Caa/Aaa	-0.06	0.79	0	probably_damaging	1	neutral	0.94	neutral	4.52	neutral	-1.49	deleterious	-3.6	high_impact	3.67	0.43	damaging	0.03	damaging	4.12	23.80	deleterious	0.55	0.6	0.63	disease	0.91	disease	0.72	disease	0.77	disease	5	1	deleterious	0.47	deleterious	2	deleterious	0.86	deleterious	-3.6	low_impact	0.89	medium_impact	2.15	high_impact	0.38	0.8	28.69	7.17	0.44	N	0.96	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13397	13397	A	G	MI.21529	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1061	354	Q	R	cAa/cGa	5.44	1	0	probably_damaging	1	neutral	0.62	neutral	4.63	neutral	0.56	deleterious	-3.6	medium_impact	2.61	0.5	damaging	0.03	damaging	3.38	23.00	deleterious	0.58	0.65	0.46	neutral	0.89	disease	0.73	disease	0.76	disease	5	1	deleterious	0.31	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.35	medium_impact	1.18	medium_impact	0.45	0.8	28.69	7.17	0.44	N	0.85	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6037	6037	G	A	MI.2153	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	134	45	G	D	gGc/gAc	4.29	1	0	probably_damaging	1	deleterious	0.01	neutral	2.81	neutral	-1.19	deleterious	-4.03	high_impact	3.77	0.38	damaging	0.02	damaging	3.74	23.30	deleterious	0.28	0.55	0.42	neutral	0.92	disease	0.7	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-0.92	medium_impact	2.38	high_impact	0.44	0.9	3.9	6.63	0.63	P	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13397	13397	A	C	MI.21530	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1061	354	Q	P	cAa/cCa	5.44	1	0	probably_damaging	1	neutral	0.34	neutral	4.42	deleterious	-4.22	deleterious	-5.4	high_impact	5.05	0.41	damaging	0.05	damaging	3.22	22.70	deleterious	0.27	0.45	0.85	disease	0.91	disease	0.83	disease	0.83	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.07	medium_impact	3.41	high_impact	0.44	0.8	28.69	7.17	0.75	P	0.95	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13397	13397	A	T	MI.21531	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1061	354	Q	L	cAa/cTa	5.44	1	0	probably_damaging	1	neutral	0.59	neutral	4.44	neutral	-2.65	deleterious	-6.29	high_impact	3.9	0.43	damaging	0.03	damaging	3.65	23.20	deleterious	0.37	0.5	0.81	disease	0.91	disease	0.7	disease	0.77	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.32	medium_impact	2.36	high_impact	0.33	0.8	28.69	7.17	0.61	P	0.96	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13398	13398	A	C	MI.21532	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1062	354	Q	H	caA/caC	8.42	1	0	probably_damaging	1	neutral	0.38	neutral	4.43	deleterious	-3.01	deleterious	-4.5	high_impact	3.96	0.44	damaging	0.03	damaging	3.50	23.10	deleterious	0.58	0.65	0.77	disease	0.85	disease	0.76	disease	0.78	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.12	medium_impact	2.41	high_impact	0.54	0.8	28.69	7.17	0.65	P	0.94	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13398	13398	A	T	MI.21533	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1062	354	Q	H	caA/caT	8.42	1	0	probably_damaging	1	neutral	0.38	neutral	4.43	deleterious	-3.01	deleterious	-4.5	high_impact	3.96	0.44	damaging	0.03	damaging	3.67	23.30	deleterious	0.58	0.65	0.77	disease	0.85	disease	0.76	disease	0.78	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.12	medium_impact	2.41	high_impact	0.54	0.8	28.69	7.17	0.68	P	0.94	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13399	13399	G	A	MI.21534	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1063	355	D	N	Gat/Aat	1.08	1	0	probably_damaging	1	neutral	0.56	neutral	4.6	neutral	-1.98	deleterious	-4.43	medium_impact	3.13	0.16	damaging	0.41	neutral	4.35	24.10	deleterious	0.79	0.8	0.5	disease	0.9	disease	0.72	disease	0.76	disease	5	1	deleterious	0.28	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.29	medium_impact	1.66	medium_impact	0.78	0.85	27.53	7.14	0.95	P	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13399	13399	G	C	MI.21535	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1063	355	D	H	Gat/Cat	1.08	1	0	probably_damaging	1	neutral	0.3	neutral	4.49	deleterious	-3.92	deleterious	-6.16	high_impact	4.59	0.33	damaging	0.3	neutral	3.71	23.30	deleterious	0.48	0.55	0.79	disease	0.92	disease	0.76	disease	0.82	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.03	medium_impact	2.99	high_impact	0.59	0.8	27.53	7.14	0.69	P	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13399	13399	G	T	MI.21536	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1063	355	D	Y	Gat/Tat	1.08	1	0	probably_damaging	1	neutral	0.4	neutral	4.52	deleterious	-3.95	deleterious	-7.95	high_impact	4.25	0.37	damaging	0.31	neutral	3.97	23.60	deleterious	0.29	0.45	0.78	disease	0.96	disease	0.76	disease	0.86	disease	7	1	deleterious	0.2	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.14	medium_impact	2.68	high_impact	0.53	0.8	27.53	7.14	0.67	P	0.99	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13400	13400	A	G	MI.21537	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1064	355	D	G	gAt/gGt	9.11	1	0	probably_damaging	1	neutral	0.48	neutral	4.49	deleterious	-4.33	deleterious	-6.23	high_impact	4.59	0.27	damaging	0.39	neutral	3.96	23.60	deleterious	0.48	0.55	0.87	disease	0.91	disease	0.73	disease	0.82	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.21	medium_impact	2.99	high_impact	0.42	0.8	27.53	7.14	0.93	P	0.98	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13400	13400	A	T	MI.21538	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1064	355	D	V	gAt/gTt	9.11	1	0	probably_damaging	1	neutral	0.43	neutral	4.49	deleterious	-4.52	deleterious	-8.01	high_impact	4.8	0.23	damaging	0.31	neutral	3.66	23.20	deleterious	0.25	0.45	0.88	disease	0.95	disease	0.72	disease	0.83	disease	7	1	deleterious	0.22	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.17	medium_impact	3.18	high_impact	0.49	0.8	27.53	7.14	0.9	P	0.99	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13400	13400	A	C	MI.21539	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1064	355	D	A	gAt/gCt	9.11	1	0	probably_damaging	1	neutral	0.85	neutral	4.53	deleterious	-3.24	deleterious	-7.12	high_impact	4.17	0.35	damaging	0.41	neutral	3.56	23.10	deleterious	0.37	0.5	0.76	disease	0.91	disease	0.72	disease	0.77	disease	5	1	deleterious	0.43	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.65	medium_impact	2.61	high_impact	0.52	0.8	27.53	7.14	0.73	P	0.94	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6037	6037	G	T	MI.2154	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	134	45	G	V	gGc/gTc	4.29	1	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.32	deleterious	-5.31	high_impact	4.62	0.49	damaging	0.03	damaging	3.66	23.20	deleterious	0.27	0.55	0.85	disease	0.92	disease	0.65	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.50	0.9	3.9	6.63	0.5	P	0.93	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13401	13401	T	A	MI.21540	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1065	355	D	E	gaT/gaA	6.59	1	0	probably_damaging	1	neutral	1	neutral	4.57	neutral	-1.76	deleterious	-3.55	high_impact	3.62	0.32	damaging	0.32	neutral	4.14	23.80	deleterious	0.59	0.65	0.62	disease	0.91	disease	0.6	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.6	low_impact	1.89	high_impact	2.1	high_impact	0.61	0.8	27.53	7.14	0.78	P	0.91	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13401	13401	T	G	MI.21541	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1065	355	D	E	gaT/gaG	6.59	1	0	probably_damaging	1	neutral	1	neutral	4.57	neutral	-1.76	deleterious	-3.55	high_impact	3.62	0.32	damaging	0.32	neutral	4.04	23.70	deleterious	0.59	0.65	0.62	disease	0.91	disease	0.6	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.6	low_impact	1.89	high_impact	2.1	high_impact	0.61	0.8	27.53	7.14	0.78	P	0.91	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13402	13402	A	G	MI.21542	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1066	356	I	V	Att/Gtt	-1.44	0	0	benign	0.08	neutral	0.62	neutral	4.43	neutral	-2.18	neutral	-0.89	low_impact	1.89	0.8	neutral	0.65	neutral	1.01	10.73	neutral	0.67	0.7	0.57	disease	0.6	disease	0.54	disease	0.51	disease	0	0.29	neutral	0.77	deleterious	-6	neutral	0.23	neutral	0.26	medium_impact	0.35	medium_impact	0.52	medium_impact	0.64	0.8	21.72	6.99	0.23	N	0.74	disease_causing	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13402	13402	A	C	MI.21543	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1066	356	I	L	Att/Ctt	-1.44	0	0	possibly_damaging	0.52	neutral	0.86	neutral	4.68	neutral	-0.84	neutral	-1.8	low_impact	1.22	0.68	neutral	0.62	neutral	1.84	15.25	deleterious	0.43	0.55	0.47	neutral	0.73	disease	0.46	neutral	0.52	disease	0	0.43	neutral	0.67	deleterious	-3	neutral	0.31	neutral	-0.78	medium_impact	0.67	medium_impact	-0.09	medium_impact	0.81	0.85	21.72	6.99	0.24	N	0.86	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13402	13402	A	T	MI.21544	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1066	356	I	F	Att/Ttt	-1.44	0	0	probably_damaging	0.96	neutral	0.75	neutral	4.35	deleterious	-3.47	deleterious	-3.6	medium_impact	3.25	0.67	neutral	0.34	neutral	3.48	23.10	deleterious	0.31	0.45	0.7	disease	0.86	disease	0.67	disease	0.72	disease	4	0.95	neutral	0.4	neutral	1	deleterious	0.78	deleterious	-2.06	low_impact	0.5	medium_impact	1.77	medium_impact	0.82	0.85	21.72	6.99	0.23	N	0.96	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13403	13403	T	G	MI.21545	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1067	356	I	S	aTt/aGt	6.81	1	0	probably_damaging	0.94	neutral	0.74	neutral	4.35	deleterious	-4.63	deleterious	-5.39	medium_impact	3.38	0.7	neutral	0.4	neutral	4.09	23.70	deleterious	0.23	0.45	0.85	disease	0.92	disease	0.68	disease	0.79	disease	6	0.93	neutral	0.4	neutral	1	deleterious	0.80	deleterious	-1.88	low_impact	0.48	medium_impact	1.88	medium_impact	0.70	0.85	21.72	6.99	0.46	N	0.96	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13403	13403	T	A	MI.21546	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1067	356	I	N	aTt/aAt	6.81	1	0	probably_damaging	0.98	neutral	0.55	neutral	4.32	deleterious	-6.02	deleterious	-6.29	high_impact	3.87	0.66	neutral	0.36	neutral	4.38	24.10	deleterious	0.2	0.45	0.87	disease	0.92	disease	0.67	disease	0.8	disease	6	0.98	neutral	0.29	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	0.28	medium_impact	2.33	high_impact	0.67	0.85	21.72	6.99	0.5	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13403	13403	T	C	MI.21547	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1067	356	I	T	aTt/aCt	6.81	1	0	possibly_damaging	0.83	neutral	0.65	neutral	4.41	deleterious	-4	deleterious	-4.49	medium_impact	3.23	0.68	neutral	0.38	neutral	3.00	22.20	deleterious	0.4	0.5	0.82	disease	0.89	disease	0.66	disease	0.75	disease	5	0.8	neutral	0.41	neutral	0	NA	0.70	deleterious	-1.4	low_impact	0.38	medium_impact	1.75	medium_impact	0.71	0.85	21.72	6.99	0.49	N	0.96	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13404	13404	T	G	MI.21548	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1068	356	I	M	atT/atG	7.27	1	0	probably_damaging	0.96	neutral	0.3	neutral	4.44	neutral	-1.32	deleterious	-2.69	low_impact	1.73	0.7	neutral	0.66	neutral	3.44	23.00	deleterious	0.46	0.55	0.53	disease	0.67	disease	0.64	disease	0.51	disease	0	0.96	neutral	0.17	neutral	-2	neutral	0.72	deleterious	-2.06	low_impact	0.03	medium_impact	0.38	medium_impact	0.90	0.95	21.72	6.99	0.48	P	0.76	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13404	13404	T	A	MI.21549	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1068	356	I	M	atT/atA	7.27	1	0	probably_damaging	0.96	neutral	0.3	neutral	4.44	neutral	-1.32	deleterious	-2.69	low_impact	1.73	0.7	neutral	0.66	neutral	3.66	23.20	deleterious	0.46	0.55	0.53	disease	0.67	disease	0.64	disease	0.51	disease	0	0.96	neutral	0.17	neutral	-2	neutral	0.72	deleterious	-2.06	low_impact	0.03	medium_impact	0.38	medium_impact	0.90	0.95	21.72	6.99	0.49	P	0.76	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6039	6039	A	T	MI.2155	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	136	46	N	Y	Aac/Tac	-15.6	0	0	benign	0.3	neutral	0.11	neutral	2.73	deleterious	-3.16	neutral	-1.24	neutral_impact	0.56	0.74	neutral	0.73	neutral	3.48	23.10	deleterious	0.37	0.55	0.56	disease	0.51	disease	0.51	disease	0.56	disease	1	0.87	neutral	0.41	neutral	-6	neutral	0.42	neutral	-0.41	medium_impact	-0.31	medium_impact	-0.58	medium_impact	0.33	0.9	15.79	51.88	0.41	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13405	13405	C	G	MI.21550	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1069	357	R	G	Cga/Gga	-2.58	0	0	probably_damaging	1	neutral	0.44	neutral	4.5	neutral	-2.78	deleterious	-6.27	high_impact	3.87	0.31	damaging	0.09	damaging	4.26	23.90	deleterious	0.39	0.5	0.82	disease	0.81	disease	0.72	disease	0.76	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.18	medium_impact	2.33	high_impact	0.43	0.8	26.53	7.28	0.53	P	0.97	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13405	13405	C	T	MI.21551	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1069	357	R	W	Cga/Tga	-2.58	0	0	probably_damaging	1	neutral	0.19	neutral	4.46	deleterious	-5.1	deleterious	-7.15	high_impact	3.87	0.35	damaging	0.06	damaging	5.18	25.50	deleterious	0.44	0.55	0.97	disease	0.9	disease	0.61	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.12	medium_impact	2.33	high_impact	0.77	0.85	26.53	7.28	0.43	N	1.00	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13406	13406	G	C	MI.21552	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1070	357	R	P	cGa/cCa	5.44	1	0	probably_damaging	1	neutral	0.28	neutral	4.47	deleterious	-3.74	deleterious	-6.27	high_impact	4.17	0.35	damaging	0.07	damaging	4.24	23.90	deleterious	0.31	0.45	0.8	disease	0.91	disease	0.8	disease	0.82	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.01	medium_impact	2.61	high_impact	0.32	0.8	26.53	7.28	0.71	P	0.99	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13406	13406	G	T	MI.21553	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1070	357	R	L	cGa/cTa	5.44	1	0	probably_damaging	1	neutral	0.73	neutral	4.57	deleterious	-3.49	deleterious	-6.23	high_impact	4.03	0.29	damaging	0.07	damaging	4.36	24.10	deleterious	0.41	0.5	0.73	disease	0.92	disease	0.66	disease	0.72	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.47	medium_impact	2.48	high_impact	0.35	0.8	26.53	7.28	0.74	P	1.00	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13406	13406	G	A	MI.21554	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1070	357	R	Q	cGa/cAa	5.44	1	0	probably_damaging	1	neutral	0.46	neutral	4.55	neutral	-2.76	deleterious	-3.58	high_impact	3.75	0.37	damaging	0.06	damaging	4.57	24.40	deleterious	0.66	0.7	0.75	disease	0.9	disease	0.68	disease	0.72	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.19	medium_impact	2.22	high_impact	0.90	0.95	26.53	7.28	0.7	P	0.99	disease_causing	1	0.24	.	.	.	.	.	.	COSM1155537	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13408	13408	A	G	MI.21555	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1072	358	K	E	Aaa/Gaa	-0.06	0.91	0	probably_damaging	1	neutral	1	neutral	4.62	neutral	-0.82	deleterious	-3.57	medium_impact	2.63	0.59	damaging	0.13	damaging	4.09	23.70	deleterious	0.64	0.7	0.48	neutral	0.87	disease	0.66	disease	0.72	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.83	deleterious	-3.6	low_impact	1.89	high_impact	1.2	medium_impact	0.80	0.85	27.36	7.29	0.21	N	0.84	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13408	13408	A	C	MI.21556	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1072	358	K	Q	Aaa/Caa	-0.06	0.91	0	probably_damaging	1	neutral	0.6	neutral	4.58	neutral	-1.68	deleterious	-3.56	medium_impact	2.81	0.54	damaging	0.15	damaging	3.55	23.10	deleterious	0.66	0.7	0.63	disease	0.83	disease	0.64	disease	0.69	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.33	medium_impact	1.36	medium_impact	0.78	0.85	27.36	7.29	0.26	N	0.82	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13409	13409	A	T	MI.21557	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1073	358	K	M	aAa/aTa	8.42	1	0	probably_damaging	1	neutral	0.14	neutral	4.56	deleterious	-4.41	deleterious	-5.37	medium_impact	2.51	0.54	damaging	0.27	damaging	3.75	23.30	deleterious	0.28	0.45	0.87	disease	0.82	disease	0.56	disease	0.67	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	-0.2	medium_impact	1.09	medium_impact	0.55	0.8	27.36	7.29	0.47	N	0.40	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13409	13409	A	C	MI.21558	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1073	358	K	T	aAa/aCa	8.42	1	0	probably_damaging	1	neutral	0.6	neutral	4.58	neutral	-2.64	deleterious	-5.37	medium_impact	2.95	0.58	damaging	0.11	damaging	3.46	23.00	deleterious	0.4	0.5	0.77	disease	0.86	disease	0.67	disease	0.72	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.33	medium_impact	1.49	medium_impact	0.65	0.8	27.36	7.29	0.42	N	0.75	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13410	13410	A	C	MI.21559	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1074	358	K	N	aaA/aaC	6.59	1	0	probably_damaging	1	neutral	0.51	neutral	4.67	neutral	-1.6	deleterious	-4.48	medium_impact	2.36	0.51	damaging	0.11	damaging	3.84	23.40	deleterious	0.67	0.7	0.69	disease	0.8	disease	0.65	disease	0.54	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.24	medium_impact	0.95	medium_impact	0.71	0.85	27.36	7.29	0.49	N	0.63	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6039	6039	A	G	MI.2156	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	136	46	N	D	Aac/Gac	-15.6	0	0	benign	0.06	deleterious	0.03	neutral	2.92	neutral	-1.36	neutral	-0.51	neutral_impact	0.74	0.67	neutral	0.54	neutral	1.92	15.69	deleterious	0.66	0.7	0.28	neutral	0.35	neutral	0.38	neutral	0.45	neutral	1	0.97	neutral	0.49	deleterious	-2	neutral	0.17	neutral	0.37	medium_impact	-0.65	medium_impact	-0.42	medium_impact	0.34	0.9	15.79	51.88	0.48	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13410	13410	A	T	MI.21560	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1074	358	K	N	aaA/aaT	6.59	1	0	probably_damaging	1	neutral	0.51	neutral	4.67	neutral	-1.6	deleterious	-4.48	medium_impact	2.36	0.51	damaging	0.11	damaging	3.90	23.50	deleterious	0.67	0.7	0.69	disease	0.8	disease	0.65	disease	0.54	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.24	medium_impact	0.95	medium_impact	0.71	0.85	27.36	7.29	0.5	N	0.63	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13411	13411	A	T	MI.21561	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1075	359	M	L	Ata/Tta	0.17	0.97	0	probably_damaging	0.98	neutral	0.77	neutral	4.81	neutral	-0.06	deleterious	-2.7	low_impact	1.82	0.54	damaging	0.08	damaging	3.26	22.80	deleterious	0.49	0.55	0.43	neutral	0.79	disease	0.65	disease	0.69	disease	4	0.98	deleterious	0.4	neutral	-2	neutral	0.69	deleterious	-2.35	low_impact	0.52	medium_impact	0.46	medium_impact	0.64	0.8	27.69	7.21	0.27	N	0.98	disease_causing	0.64	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13411	13411	A	C	MI.21562	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1075	359	M	L	Ata/Cta	0.17	0.97	0	probably_damaging	0.98	neutral	0.77	neutral	4.81	neutral	-0.06	deleterious	-2.7	low_impact	1.82	0.54	damaging	0.08	damaging	3.18	22.70	deleterious	0.49	0.55	0.43	neutral	0.79	disease	0.65	disease	0.69	disease	4	0.98	deleterious	0.4	neutral	-2	neutral	0.69	deleterious	-2.35	low_impact	0.52	medium_impact	0.46	medium_impact	0.64	0.8	27.69	7.21	0.27	N	0.98	disease_causing	0.64	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13411	13411	A	G	MI.21563	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1075	359	M	V	Ata/Gta	0.17	0.97	0	probably_damaging	0.99	neutral	0.63	neutral	4.63	neutral	-2.35	deleterious	-3.59	high_impact	3.52	0.53	damaging	0.08	damaging	2.69	20.80	deleterious	0.46	0.55	0.65	disease	0.82	disease	0.73	disease	0.75	disease	5	0.99	deleterious	0.32	neutral	2	deleterious	0.77	deleterious	-2.64	low_impact	0.36	medium_impact	2.01	high_impact	0.58	0.8	27.69	7.21	0.33	N	0.95	disease_causing	0.69	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13412	13412	T	C	MI.21564	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1076	359	M	T	aTa/aCa	5.21	1	0	probably_damaging	1	neutral	0.76	neutral	4.59	deleterious	-3.72	deleterious	-5.39	medium_impact	3.11	0.55	damaging	0.13	damaging	3.10	22.50	deleterious	0.37	0.5	0.82	disease	0.88	disease	0.69	disease	0.75	disease	5	1	deleterious	0.38	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	0.51	medium_impact	1.64	medium_impact	0.37	0.8	27.69	7.21	0.37	N	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13412	13412	T	A	MI.21565	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1076	359	M	K	aTa/aAa	5.21	1	0	probably_damaging	1	neutral	0.96	neutral	4.53	deleterious	-4.91	deleterious	-5.39	high_impact	3.83	0.61	neutral	0.09	damaging	4.36	24.10	deleterious	0.17	0.45	0.91	disease	0.92	disease	0.79	disease	0.85	disease	7	1	deleterious	0.48	deleterious	2	deleterious	0.89	deleterious	-3.6	low_impact	1	medium_impact	2.3	high_impact	0.36	0.8	27.69	7.21	0.51	N	1.00	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13413	13413	A	C	MI.21566	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1077	359	M	I	atA/atC	5.67	1	0	probably_damaging	0.99	neutral	0.47	neutral	4.58	neutral	-2.29	deleterious	-3.59	medium_impact	2.35	0.6	damaging	0.12	damaging	3.48	23.10	deleterious	0.46	0.55	0.73	disease	0.81	disease	0.73	disease	0.75	disease	5	0.99	deleterious	0.24	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	0.2	medium_impact	0.94	medium_impact	0.70	0.85	27.69	7.21	0.48	N	0.94	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13413	13413	A	T	MI.21567	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1077	359	M	I	atA/atT	5.67	1	0	probably_damaging	0.99	neutral	0.47	neutral	4.58	neutral	-2.29	deleterious	-3.59	medium_impact	2.35	0.6	damaging	0.12	damaging	3.66	23.20	deleterious	0.46	0.55	0.73	disease	0.81	disease	0.73	disease	0.75	disease	5	0.99	deleterious	0.24	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	0.2	medium_impact	0.94	medium_impact	0.70	0.85	27.69	7.21	0.49	N	0.94	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13414	13414	G	C	MI.21568	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1078	360	G	R	Gga/Cga	0.4	0.98	0	probably_damaging	1	neutral	0.46	neutral	4.55	neutral	-2.92	deleterious	-7.19	medium_impact	3.5	0.56	damaging	0.02	damaging	3.97	23.60	deleterious	0.31	0.45	0.72	disease	0.91	disease	0.81	disease	0.83	disease	7	1	deleterious	0.23	neutral	1	deleterious	0.90	deleterious	-3.6	low_impact	0.19	medium_impact	1.99	medium_impact	0.91	0.95	28.19	7.23	0.41	N	1.00	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13414	13414	G	T	MI.21569	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1078	360	G	W	Gga/Tga	0.4	0.98	0	probably_damaging	1	neutral	0.18	neutral	4.4	deleterious	-8.33	deleterious	-7.19	high_impact	4.45	0.56	damaging	0.02	damaging	4.45	24.20	deleterious	0.19	0.45	0.98	disease	0.91	disease	0.76	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.13	medium_impact	2.86	high_impact	0.53	0.8	28.19	7.23	0.48	N	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6039	6039	A	C	MI.2157	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	136	46	N	H	Aac/Cac	-15.6	0	0	possibly_damaging	0.49	neutral	0.07	neutral	2.79	neutral	-2.75	neutral	-0.91	low_impact	1.84	0.75	neutral	0.63	neutral	2.87	21.70	deleterious	0.59	0.65	0.47	neutral	0.35	neutral	0.51	disease	0.47	neutral	1	0.92	neutral	0.29	neutral	-3	neutral	0.38	neutral	-0.74	medium_impact	-0.43	medium_impact	0.6	medium_impact	0.39	0.9	15.79	51.88	0.46	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13415	13415	G	A	MI.21570	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1079	360	G	E	gGa/gAa	7.27	1	0	probably_damaging	1	neutral	0.49	neutral	4.55	deleterious	-3.88	deleterious	-7.19	high_impact	4.66	0.54	damaging	0.02	damaging	3.96	23.60	deleterious	0.28	0.45	0.75	disease	0.9	disease	0.8	disease	0.82	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.22	medium_impact	3.05	high_impact	0.73	0.85	28.19	7.23	0.65	P	1.00	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13415	13415	G	C	MI.21571	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1079	360	G	A	gGa/gCa	7.27	1	0	probably_damaging	1	neutral	0.68	neutral	4.51	neutral	-2.94	deleterious	-5.39	high_impact	3.58	0.55	damaging	0.03	damaging	3.20	22.70	deleterious	0.4	0.5	0.68	disease	0.78	disease	0.59	disease	0.67	disease	3	1	deleterious	0.34	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.41	medium_impact	2.07	high_impact	0.78	0.85	28.19	7.23	0.39	N	0.79	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13415	13415	G	T	MI.21572	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1079	360	G	V	gGa/gTa	7.27	1	0	probably_damaging	1	neutral	0.56	neutral	4.43	deleterious	-5.45	deleterious	-8.09	high_impact	4.66	0.54	damaging	0.02	damaging	3.84	23.40	deleterious	0.23	0.45	0.89	disease	0.9	disease	0.71	disease	0.81	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.29	medium_impact	3.05	high_impact	0.54	0.8	28.19	7.23	0.56	P	0.98	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13417	13417	G	T	MI.21573	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1081	361	G	W	Gga/Tga	-9.46	0	0	probably_damaging	1	neutral	0.18	neutral	4.3	deleterious	-8.94	deleterious	-7.17	high_impact	4.73	0.68	neutral	0.06	damaging	4.57	24.40	deleterious	0.24	0.45	1	disease	0.89	disease	0.75	disease	0.88	disease	8	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.13	medium_impact	3.12	high_impact	0.38	0.8	8.13	12.67	0.5	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13417	13417	G	C	MI.21574	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1081	361	G	R	Gga/Cga	-9.46	0	0	probably_damaging	1	neutral	0.36	neutral	4.39	deleterious	-5.61	deleterious	-7.15	high_impact	3.58	0.65	neutral	0.05	damaging	4.06	23.70	deleterious	0.3	0.45	0.97	disease	0.89	disease	0.81	disease	0.85	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.1	medium_impact	2.07	high_impact	0.82	0.85	8.13	12.67	0.32	N	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13418	13418	G	A	MI.21575	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1082	361	G	E	gGa/gAa	1.54	0.97	0	probably_damaging	0.99	neutral	0.29	neutral	4.39	deleterious	-5.18	deleterious	-7.15	high_impact	4.38	0.67	neutral	0.06	damaging	3.98	23.60	deleterious	0.32	0.5	0.96	disease	0.88	disease	0.81	disease	0.86	disease	7	0.99	deleterious	0.15	neutral	2	deleterious	0.91	deleterious	-2.64	low_impact	0.02	medium_impact	2.8	high_impact	0.57	0.8	8.13	12.67	0.5	N	0.95	polymorphism	1	0.35	.	.	.	.	.	.	COSM1155540	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13418	13418	G	T	MI.21576	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1082	361	G	V	gGa/gTa	1.54	0.97	0	probably_damaging	0.99	neutral	0.51	neutral	4.33	deleterious	-6.4	deleterious	-8.05	high_impact	3.92	0.63	neutral	0.05	damaging	3.84	23.40	deleterious	0.27	0.45	0.96	disease	0.88	disease	0.69	disease	0.83	disease	7	0.99	deleterious	0.26	neutral	2	deleterious	0.91	deleterious	-2.64	low_impact	0.24	medium_impact	2.38	high_impact	0.38	0.8	8.13	12.67	0.4	N	0.96	polymorphism	0.99	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13418	13418	G	C	MI.21577	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1082	361	G	A	gGa/gCa	1.54	0.97	0	probably_damaging	0.95	neutral	0.52	neutral	4.39	deleterious	-4.96	deleterious	-5.36	medium_impact	2.34	0.63	neutral	0.28	neutral	3.14	22.60	deleterious	0.29	0.45	0.81	disease	0.69	disease	0.53	disease	0.57	disease	1	0.94	neutral	0.29	neutral	1	deleterious	0.86	deleterious	-1.96	low_impact	0.25	medium_impact	0.94	medium_impact	0.74	0.85	8.13	12.67	0.35	N	0.78	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13420	13420	C	G	MI.21578	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1084	362	L	V	Cta/Gta	-14.73	0	0	probably_damaging	1	neutral	0.57	neutral	4.25	deleterious	-3.67	deleterious	-2.7	medium_impact	2.62	0.69	neutral	0.14	damaging	3.48	23.10	deleterious	0.46	0.55	0.7	disease	0.56	disease	0.27	neutral	0.5	neutral	0	1	deleterious	0.29	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.3	medium_impact	1.19	medium_impact	0.66	0.8	9.62	12.09	0.21	N	0.49	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13420	13420	C	A	MI.21579	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1084	362	L	M	Cta/Ata	-14.73	0	0	probably_damaging	1	neutral	0.3	neutral	4.21	deleterious	-4.78	neutral	-1.8	medium_impact	1.96	0.76	neutral	0.44	neutral	2.56	19.86	deleterious	0.39	0.5	0.75	disease	0.19	neutral	0.19	neutral	0.48	neutral	1	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.03	medium_impact	0.59	medium_impact	0.78	0.85	9.62	12.09	0.42	N	0.16	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6040	6040	A	C	MI.2158	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	137	46	N	T	aAc/aCc	-1.03	0	0.02	benign	0	neutral	0.42	neutral	2.81	neutral	2.02	neutral	0.47	neutral_impact	-0.78	0.78	neutral	0.98	neutral	0.43	6.85	deleterious	0.54	0.6	0.21	neutral	0.26	neutral	0.22	neutral	0.43	neutral	1	0.58	neutral	0.71	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.12	medium_impact	-1.82	low_impact	0.39	0.9	15.79	51.88	0.39	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13421	13421	T	G	MI.21580	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1085	362	L	R	cTa/cGa	-1.44	0	0	probably_damaging	1	neutral	0.48	neutral	4.14	deleterious	-6.8	deleterious	-5.39	high_impact	4.27	0.61	neutral	0.08	damaging	4.24	23.90	deleterious	0.3	0.45	0.94	disease	0.88	disease	0.74	disease	0.83	disease	7	1	deleterious	0.24	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.21	medium_impact	2.7	high_impact	0.54	0.8	9.62	12.09	0.35	N	0.98	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13421	13421	T	C	MI.21581	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1085	362	L	P	cTa/cCa	-1.44	0	0	probably_damaging	1	neutral	0.27	neutral	4.13	deleterious	-7.58	deleterious	-6.29	high_impact	4.82	0.55	damaging	0.08	damaging	4.00	23.60	deleterious	0.31	0.45	0.95	disease	0.85	disease	0.73	disease	0.83	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.93	deleterious	-3.6	low_impact	-0.01	medium_impact	3.2	high_impact	0.57	0.8	9.62	12.09	0.55	P	0.88	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13421	13421	T	A	MI.21582	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1085	362	L	Q	cTa/cAa	-1.44	0	0	probably_damaging	1	neutral	0.42	neutral	4.13	deleterious	-7.1	deleterious	-5.39	high_impact	4.47	0.68	neutral	0.09	damaging	4.30	24.00	deleterious	0.27	0.45	0.94	disease	0.8	disease	0.61	disease	0.81	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.16	medium_impact	2.88	high_impact	0.65	0.8	9.62	12.09	0.35	N	0.93	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13423	13423	C	G	MI.21583	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1087	363	L	V	Ctc/Gtc	-5.33	0	0	benign	0.36	neutral	0.67	neutral	4.62	neutral	-0.18	neutral	-0.63	neutral_impact	0.75	0.81	neutral	0.71	neutral	1.63	14.03	neutral	0.62	0.65	0.44	neutral	0.29	neutral	0.23	neutral	0.46	neutral	1	0.29	neutral	0.66	deleterious	-6	neutral	0.50	deleterious	-0.51	medium_impact	0.4	medium_impact	-0.52	medium_impact	0.41	0.8	25.37	15.03	0.27	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13423	13423	C	A	MI.21584	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1087	363	L	I	Ctc/Atc	-5.33	0	0	benign	0.36	neutral	0.51	neutral	4.61	neutral	-0.17	neutral	-0.22	neutral_impact	-0.16	0.84	neutral	0.77	neutral	2.41	18.89	deleterious	0.47	0.55	0.44	neutral	0.23	neutral	0.22	neutral	0.46	neutral	1	0.41	neutral	0.58	deleterious	-6	neutral	0.46	deleterious	-0.51	medium_impact	0.24	medium_impact	-1.35	low_impact	0.50	0.8	25.37	15.03	0.34	N	0.28	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13423	13423	C	T	MI.21585	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1087	363	L	F	Ctc/Ttc	-5.33	0	0	benign	0.01	neutral	0.73	neutral	4.6	neutral	-0.64	neutral	2.97	neutral_impact	-0.2	0.92	neutral	0.97	neutral	-0.58	0.14	neutral	0.53	0.6	0.47	neutral	0.21	neutral	0.11	neutral	0.37	neutral	3	0.24	neutral	0.86	deleterious	-6	neutral	0.16	neutral	1.15	medium_impact	0.47	medium_impact	-1.39	low_impact	0.52	0.8	25.37	15.03	0.32	N	0.19	polymorphism	1	0.00	rs879030221	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13424	13424	T	C	MI.21586	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1088	363	L	P	cTc/cCc	-0.06	0	0	possibly_damaging	0.9	neutral	0.38	neutral	4.47	deleterious	-3.11	deleterious	-2.84	low_impact	1.86	0.57	damaging	0.45	neutral	2.82	21.50	deleterious	0.3	0.45	0.85	disease	0.76	disease	0.55	disease	0.8	disease	6	0.91	neutral	0.24	neutral	-3	neutral	0.86	deleterious	-1.65	low_impact	0.12	medium_impact	0.5	medium_impact	0.38	0.8	25.37	15.03	0.25	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	COSM1155541	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13424	13424	T	A	MI.21587	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1088	363	L	H	cTc/cAc	-0.06	0	0	probably_damaging	0.95	neutral	0.6	neutral	4.47	neutral	-1.98	neutral	-0.07	neutral_impact	-0.24	0.8	neutral	0.84	neutral	1.60	13.87	neutral	0.34	0.5	0.69	disease	0.15	neutral	0.12	neutral	0.38	neutral	3	0.95	neutral	0.33	neutral	-2	neutral	0.70	deleterious	-1.96	low_impact	0.33	medium_impact	-1.42	low_impact	0.59	0.8	25.37	15.03	0.33	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13424	13424	T	G	MI.21588	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1088	363	L	R	cTc/cGc	-0.06	0	0	possibly_damaging	0.83	neutral	0.7	neutral	4.54	neutral	0.58	neutral	-1.99	neutral_impact	0	0.73	neutral	0.62	neutral	2.87	21.70	deleterious	0.47	0.55	0.39	neutral	0.7	disease	0.41	neutral	0.53	disease	1	0.8	neutral	0.44	neutral	-3	neutral	0.74	deleterious	-1.4	low_impact	0.44	medium_impact	-1.2	low_impact	0.55	0.8	25.37	15.03	0.22	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13426	13426	A	G	MI.21589	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1090	364	K	E	Aaa/Gaa	-3.5	0	0	probably_damaging	1	neutral	0.94	neutral	4.5	neutral	-2.68	deleterious	-3.23	medium_impact	2.79	0.78	neutral	0.2	damaging	4.05	23.70	deleterious	0.64	0.7	0.7	disease	0.72	disease	0.56	disease	0.64	disease	3	1	deleterious	0.47	deleterious	1	deleterious	0.82	deleterious	-3.6	low_impact	0.89	medium_impact	1.35	medium_impact	0.64	0.8	17.08	16.03	0.15	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6040	6040	A	G	MI.2159	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	137	46	N	S	aAc/aGc	-1.03	0	0.02	benign	0	neutral	1	neutral	2.88	neutral	-0.44	neutral	1.55	neutral_impact	-2.6	0.8	neutral	0.98	neutral	-1.19	0.01	neutral	0.64	0.65	0.18	neutral	0.05	neutral	0.19	neutral	0.21	neutral	6	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	1.86	high_impact	-3.5	low_impact	0.14	0.9	15.79	51.88	0.36	N	0.10	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13426	13426	A	C	MI.21590	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1090	364	K	Q	Aaa/Caa	-3.5	0	0	probably_damaging	1	neutral	0.69	neutral	4.51	neutral	-2.53	deleterious	-3.19	medium_impact	2.21	0.82	neutral	0.28	damaging	3.46	23.00	deleterious	0.73	0.75	0.79	disease	0.56	disease	0.36	neutral	0.54	disease	1	1	deleterious	0.35	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.42	medium_impact	0.82	medium_impact	0.70	0.85	17.08	16.03	0.17	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13427	13427	A	C	MI.21591	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1091	364	K	T	aAa/aCa	2.46	0.81	0	probably_damaging	1	neutral	0.77	neutral	4.5	neutral	-2.81	deleterious	-4.87	low_impact	1.7	0.82	neutral	0.42	neutral	2.60	20.20	deleterious	0.48	0.55	0.77	disease	0.47	neutral	0.36	neutral	0.63	disease	3	1	deleterious	0.39	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.52	medium_impact	0.35	medium_impact	0.61	0.8	17.08	16.03	0.26	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13427	13427	A	T	MI.21592	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1091	364	K	M	aAa/aTa	2.46	0.81	0	probably_damaging	1	neutral	0.3	neutral	4.48	deleterious	-4.71	deleterious	-4.83	medium_impact	2.1	0.84	neutral	0.29	neutral	4.01	23.60	deleterious	0.4	0.5	0.94	disease	0.57	disease	0.37	neutral	0.79	disease	6	1	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.03	medium_impact	0.72	medium_impact	0.59	0.8	17.08	16.03	0.39	N	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13428	13428	A	C	MI.21593	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1092	364	K	N	aaA/aaC	3.61	0.83	0	probably_damaging	1	neutral	0.64	neutral	4.57	neutral	-2.77	deleterious	-3.84	low_impact	0.96	0.81	neutral	0.9	neutral	2.40	18.80	deleterious	0.79	0.8	0.68	disease	0.35	neutral	0.3	neutral	0.64	disease	3	1	deleterious	0.32	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.37	medium_impact	-0.33	medium_impact	0.78	0.85	17.08	16.03	0.33	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13428	13428	A	T	MI.21594	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1092	364	K	N	aaA/aaT	3.61	0.83	0	probably_damaging	1	neutral	0.64	neutral	4.57	neutral	-2.77	deleterious	-3.84	low_impact	0.96	0.81	neutral	0.9	neutral	2.43	19.00	deleterious	0.79	0.8	0.68	disease	0.35	neutral	0.3	neutral	0.64	disease	3	1	deleterious	0.32	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.37	medium_impact	-0.33	medium_impact	0.78	0.85	17.08	16.03	0.34	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13429	13429	A	C	MI.21595	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1093	365	T	P	Acc/Ccc	0.63	0.11	0	possibly_damaging	0.81	neutral	0.35	neutral	4.59	neutral	-2.3	neutral	-2.24	low_impact	1.22	0.81	neutral	0.98	neutral	1.78	14.85	neutral	0.23	0.45	0.5	disease	0.65	disease	0.46	neutral	0.47	neutral	1	0.83	neutral	0.27	neutral	-3	neutral	0.53	deleterious	-1.34	low_impact	0.08	medium_impact	-0.09	medium_impact	0.53	0.8	23.71	12.55	0.35	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13429	13429	A	T	MI.21596	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1093	365	T	S	Acc/Tcc	0.63	0.11	0	benign	0.32	neutral	0.8	neutral	4.71	neutral	0.06	neutral	-1.13	neutral_impact	-0.36	0.85	neutral	0.98	neutral	0.10	3.56	deleterious	0.55	0.6	0.41	neutral	0.21	neutral	0.27	neutral	0.37	neutral	3	0.21	neutral	0.74	deleterious	-6	neutral	0.21	neutral	-0.44	medium_impact	0.57	medium_impact	-1.53	low_impact	0.57	0.8	23.71	12.55	0.34	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13429	13429	A	G	MI.21597	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1093	365	T	A	Acc/Gcc	0.63	0.11	0	benign	0.02	neutral	0.78	neutral	4.64	neutral	-0.23	neutral	-1.1	neutral_impact	-0.07	0.84	neutral	1	neutral	-0.12	1.59	neutral	0.7	0.75	0.52	disease	0.17	neutral	0.29	neutral	0.26	neutral	5	0.17	neutral	0.88	deleterious	-6	neutral	0.12	neutral	0.86	medium_impact	0.54	medium_impact	-1.27	low_impact	0.52	0.8	23.71	12.55	0.33	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13430	13430	C	G	MI.21598	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1094	365	T	S	aCc/aGc	-6.94	0	0	benign	0.32	neutral	0.8	neutral	4.71	neutral	0.06	neutral	-1.13	neutral_impact	-0.36	0.85	neutral	0.98	neutral	0.45	7.06	deleterious	0.55	0.6	0.41	neutral	0.21	neutral	0.27	neutral	0.37	neutral	3	0.21	neutral	0.74	deleterious	-6	neutral	0.21	neutral	-0.44	medium_impact	0.57	medium_impact	-1.53	low_impact	0.57	0.8	23.71	12.55	0.29	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13430	13430	C	A	MI.21599	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1094	365	T	N	aCc/aAc	-6.94	0	0	possibly_damaging	0.85	neutral	0.52	neutral	4.63	neutral	-0.89	deleterious	-2.65	neutral_impact	0.6	0.82	neutral	0.69	neutral	3.45	23.00	deleterious	0.77	0.8	0.64	disease	0.43	neutral	0.45	neutral	0.61	disease	2	0.83	neutral	0.34	neutral	-3	neutral	0.50	deleterious	-1.46	low_impact	0.25	medium_impact	-0.66	medium_impact	0.71	0.85	23.71	12.55	0.25	N	0.63	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8627	8627	C	G	MI.216	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	101	34	S	C	tCc/tGc	0.59	0	0	probably_damaging	1	neutral	0.19	neutral	4.26	deleterious	-4.22	deleterious	-2.86	medium_impact	2.38	0.8	neutral	0.28	neutral	3.43	23.00	deleterious	0.38	0.65	0.89	disease	0.65	disease	0.36	neutral	0.61	disease	2	1	deleterious	0.1	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.06	medium_impact	0.94	medium_impact	0.62	0.9	9.73	14.65	0.31	N	0.67	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6040	6040	A	T	MI.2160	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	137	46	N	I	aAc/aTc	-1.03	0	0.02	benign	0.09	deleterious	0.04	neutral	2.74	neutral	-2.25	neutral	-1.14	neutral_impact	0.4	0.73	neutral	0.73	neutral	4.03	23.60	deleterious	0.33	0.55	0.45	neutral	0.52	disease	0.36	neutral	0.5	neutral	0	0.96	neutral	0.48	deleterious	-2	neutral	0.22	neutral	0.19	medium_impact	-0.58	medium_impact	-0.73	medium_impact	0.27	0.9	15.79	51.88	0.47	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13430	13430	C	T	MI.21600	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1094	365	T	I	aCc/aTc	-6.94	0	0	benign	0.02	neutral	0.66	neutral	4.64	neutral	-1.11	deleterious	-2.56	neutral_impact	0.15	0.83	neutral	0.97	neutral	0.34	6.04	deleterious	0.66	0.7	0.57	disease	0.31	neutral	0.33	neutral	0.59	disease	2	0.3	neutral	0.82	deleterious	-6	neutral	0.15	neutral	0.86	medium_impact	0.39	medium_impact	-1.07	low_impact	0.68	0.85	23.71	12.55	0.3	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13432	13432	A	G	MI.21601	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1096	366	M	V	Ata/Gta	-20	0	0	benign	0.26	neutral	0.58	neutral	4.58	deleterious	-3.56	neutral	-2.15	medium_impact	2.26	0.8	neutral	0.66	neutral	1.04	10.87	neutral	0.52	0.6	0.71	disease	0.39	neutral	0.71	disease	0.69	disease	4	0.31	neutral	0.66	deleterious	-3	neutral	0.28	neutral	-0.32	medium_impact	0.31	medium_impact	0.86	medium_impact	0.50	0.8	3.98	9.82	0.27	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13432	13432	A	C	MI.21602	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1096	366	M	L	Ata/Cta	-20	0	0	benign	0.01	neutral	0.78	neutral	4.62	neutral	-1.9	neutral	-0.29	neutral_impact	-0.44	0.85	neutral	0.98	neutral	-1.20	0.01	neutral	0.58	0.65	0.58	disease	0.13	neutral	0.31	neutral	0.29	neutral	4	0.19	neutral	0.89	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.54	medium_impact	-1.61	low_impact	0.61	0.8	3.98	9.82	0.31	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13432	13432	A	T	MI.21603	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1096	366	M	L	Ata/Tta	-20	0	0	benign	0.01	neutral	0.78	neutral	4.62	neutral	-1.9	neutral	-0.29	neutral_impact	-0.44	0.85	neutral	0.98	neutral	-1.02	0.02	neutral	0.58	0.65	0.58	disease	0.13	neutral	0.31	neutral	0.29	neutral	4	0.19	neutral	0.89	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.54	medium_impact	-1.61	low_impact	0.61	0.8	3.98	9.82	0.32	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13433	13433	T	A	MI.21604	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1097	366	M	K	aTa/aAa	-4.19	0	0	possibly_damaging	0.71	neutral	0.48	neutral	4.52	deleterious	-4.25	deleterious	-4.43	medium_impact	3.15	0.8	neutral	0.42	neutral	2.41	18.91	deleterious	0.2	0.45	0.8	disease	0.65	disease	0.76	disease	0.78	disease	6	0.69	neutral	0.39	neutral	0	NA	0.58	deleterious	-1.12	low_impact	0.21	medium_impact	1.67	medium_impact	0.34	0.8	3.98	9.82	0.33	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13433	13433	T	C	MI.21605	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1097	366	M	T	aTa/aCa	-4.19	0	0	possibly_damaging	0.64	neutral	0.54	neutral	4.55	deleterious	-3.75	deleterious	-3.95	medium_impact	2	0.74	neutral	0.75	neutral	0.02	2.82	deleterious	0.48	0.55	0.64	disease	0.22	neutral	0.47	neutral	0.46	neutral	1	0.6	neutral	0.45	neutral	0	NA	0.41	neutral	-0.98	medium_impact	0.27	medium_impact	0.62	medium_impact	0.38	0.8	3.98	9.82	0.29	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13434	13434	A	C	MI.21606	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1098	366	M	I	atA/atC	4.29	0.47	0.02	benign	0.25	neutral	0.45	neutral	4.58	deleterious	-3.01	neutral	-1.67	medium_impact	2.07	0.77	neutral	0.72	neutral	1.64	14.07	neutral	0.52	0.6	0.73	disease	0.28	neutral	0.47	neutral	0.58	disease	2	0.46	neutral	0.6	deleterious	-3	neutral	0.28	neutral	-0.29	medium_impact	0.18	medium_impact	0.69	medium_impact	0.61	0.8	3.98	9.82	0.38	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13434	13434	A	T	MI.21607	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1098	366	M	I	atA/atT	4.29	0.47	0.02	benign	0.25	neutral	0.45	neutral	4.58	deleterious	-3.01	neutral	-1.67	medium_impact	2.07	0.77	neutral	0.72	neutral	1.73	14.56	neutral	0.52	0.6	0.73	disease	0.28	neutral	0.47	neutral	0.58	disease	2	0.46	neutral	0.6	deleterious	-3	neutral	0.28	neutral	-0.29	medium_impact	0.18	medium_impact	0.69	medium_impact	0.61	0.8	3.98	9.82	0.38	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13435	13435	C	G	MI.21608	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1099	367	P	A	Cct/Gct	-7.4	0	0	probably_damaging	1	neutral	0.53	neutral	4.29	deleterious	-5.76	deleterious	-7.19	high_impact	4.57	0.4	damaging	0.16	damaging	3.15	22.60	deleterious	0.3	0.45	0.86	disease	0.56	disease	0.76	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.26	medium_impact	2.97	high_impact	0.58	0.8	27.03	7.15	0.52	N	0.73	polymorphism	0.81	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13435	13435	C	T	MI.21609	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1099	367	P	S	Cct/Tct	-7.4	0	0	probably_damaging	1	neutral	0.45	neutral	4.26	deleterious	-5.65	deleterious	-7.19	medium_impact	3.29	0.47	damaging	0.16	damaging	3.98	23.60	deleterious	0.47	0.55	0.88	disease	0.75	disease	0.75	disease	0.81	disease	6	1	deleterious	0.23	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.18	medium_impact	1.8	medium_impact	0.24	0.8	27.03	7.15	0.3	N	0.78	polymorphism	0.73	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6041	6041	C	G	MI.2161	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	138	46	N	K	aaC/aaG	2.44	0.01	0	benign	0.06	neutral	0.06	neutral	2.83	neutral	-1.08	neutral	-0.38	neutral_impact	0.26	0.65	neutral	0.54	neutral	2.12	16.99	deleterious	0.65	0.7	0.23	neutral	0.49	neutral	0.4	neutral	0.51	disease	0	0.94	neutral	0.5	deleterious	-6	neutral	0.17	neutral	0.37	medium_impact	-0.47	medium_impact	-0.86	medium_impact	0.39	0.9	15.79	51.88	0.5	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13435	13435	C	A	MI.21610	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1099	367	P	T	Cct/Act	-7.4	0	0	probably_damaging	1	neutral	0.42	neutral	4.25	deleterious	-6.1	deleterious	-7.19	high_impact	4.22	0.37	damaging	0.13	damaging	3.78	23.40	deleterious	0.37	0.5	0.84	disease	0.72	disease	0.75	disease	0.79	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.16	medium_impact	2.65	high_impact	0.63	0.8	27.03	7.15	0.45	N	0.91	polymorphism	0.74	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13436	13436	C	G	MI.21611	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1100	367	P	R	cCt/cGt	5.44	1	0	probably_damaging	1	neutral	0.36	neutral	4.29	deleterious	-5.31	deleterious	-8.09	high_impact	3.84	0.44	damaging	0.13	damaging	3.62	23.20	deleterious	0.28	0.45	0.9	disease	0.84	disease	0.86	disease	0.85	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.1	medium_impact	2.31	high_impact	0.50	0.8	27.03	7.15	0.66	P	0.64	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13436	13436	C	T	MI.21612	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1100	367	P	L	cCt/cTt	5.44	1	0	probably_damaging	1	neutral	0.7	neutral	4.24	deleterious	-6.39	deleterious	-8.99	high_impact	4.08	0.34	damaging	0.11	damaging	4.33	24.00	deleterious	0.41	0.5	0.83	disease	0.8	disease	0.74	disease	0.78	disease	6	1	deleterious	0.35	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.44	medium_impact	2.52	high_impact	0.77	0.85	27.03	7.15	0.62	P	0.97	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13436	13436	C	A	MI.21613	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1100	367	P	H	cCt/cAt	5.44	1	0	probably_damaging	1	neutral	0.55	neutral	4.22	deleterious	-7.39	deleterious	-8.09	high_impact	5.12	0.41	damaging	0.11	damaging	4.11	23.70	deleterious	0.29	0.45	0.95	disease	0.8	disease	0.83	disease	0.86	disease	7	1	deleterious	0.28	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.28	medium_impact	3.47	high_impact	0.55	0.8	27.03	7.15	0.67	P	0.72	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13438	13438	C	A	MI.21614	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1102	368	L	I	Ctc/Atc	-5.56	0	0	possibly_damaging	0.81	neutral	0.51	neutral	4.69	neutral	-0.24	neutral	-0.23	neutral_impact	-0.48	0.83	neutral	0.95	neutral	2.64	20.50	deleterious	0.57	0.65	0.43	neutral	0.12	neutral	0.15	neutral	0.31	neutral	4	0.79	neutral	0.35	neutral	-3	neutral	0.66	deleterious	-1.34	low_impact	0.24	medium_impact	-1.64	low_impact	0.80	0.85	28.03	18.12	0.42	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13438	13438	C	T	MI.21615	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1102	368	L	F	Ctc/Ttc	-5.56	0	0	benign	0.17	neutral	0.86	neutral	4.54	neutral	-1.19	neutral	2.09	neutral_impact	0.02	0.82	neutral	0.98	neutral	1.27	12.12	neutral	0.64	0.7	0.35	neutral	0.06	neutral	0.14	neutral	0.2	neutral	6	0.08	neutral	0.85	deleterious	-6	neutral	0.65	deleterious	-0.09	medium_impact	0.67	medium_impact	-1.18	low_impact	0.71	0.85	28.03	18.12	0.33	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13438	13438	C	G	MI.21616	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1102	368	L	V	Ctc/Gtc	-5.56	0	0	possibly_damaging	0.86	neutral	0.59	neutral	4.55	neutral	0	neutral	-1.03	neutral_impact	0.39	0.78	neutral	0.87	neutral	3.41	23.00	deleterious	0.56	0.6	0.4	neutral	0.19	neutral	0.19	neutral	0.38	neutral	2	0.84	neutral	0.37	neutral	-3	neutral	0.66	deleterious	-1.5	low_impact	0.32	medium_impact	-0.85	medium_impact	0.61	0.8	28.03	18.12	0.35	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13439	13439	T	A	MI.21617	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1103	368	L	H	cTc/cAc	-0.06	0	0	probably_damaging	0.99	neutral	0.56	neutral	4.43	deleterious	-4.14	deleterious	-2.6	medium_impact	2.64	0.76	neutral	0.56	neutral	4.09	23.70	deleterious	0.38	0.5	0.91	disease	0.49	neutral	0.52	disease	0.65	disease	3	0.99	deleterious	0.29	neutral	1	deleterious	0.81	deleterious	-2.64	low_impact	0.29	medium_impact	1.21	medium_impact	0.67	0.85	28.03	18.12	0.26	N	0.71	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13439	13439	T	C	MI.21618	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1103	368	L	P	cTc/cCc	-0.06	0	0	probably_damaging	0.99	neutral	0.31	neutral	4.42	deleterious	-4.58	deleterious	-4.17	medium_impact	2.56	0.6	damaging	0.43	neutral	3.93	23.50	deleterious	0.24	0.45	0.87	disease	0.74	disease	0.68	disease	0.8	disease	6	0.99	deleterious	0.16	neutral	1	deleterious	0.87	deleterious	-2.64	low_impact	0.04	medium_impact	1.14	medium_impact	0.59	0.8	28.03	18.12	0.26	N	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13439	13439	T	G	MI.21619	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1103	368	L	R	cTc/cGc	-0.06	0	0	probably_damaging	0.98	neutral	0.35	neutral	4.43	neutral	-2.41	deleterious	-3.4	medium_impact	2.48	0.7	neutral	0.51	neutral	4.21	23.90	deleterious	0.26	0.45	0.76	disease	0.72	disease	0.68	disease	0.75	disease	5	0.99	deleterious	0.19	neutral	1	deleterious	0.84	deleterious	-2.35	low_impact	0.08	medium_impact	1.06	medium_impact	0.60	0.8	28.03	18.12	0.27	N	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6041	6041	C	A	MI.2162	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	138	46	N	K	aaC/aaA	2.44	0.01	0	benign	0.06	neutral	0.06	neutral	2.83	neutral	-1.08	neutral	-0.38	neutral_impact	0.26	0.65	neutral	0.54	neutral	2.60	20.20	deleterious	0.65	0.7	0.23	neutral	0.49	neutral	0.4	neutral	0.51	disease	0	0.94	neutral	0.5	deleterious	-6	neutral	0.17	neutral	0.37	medium_impact	-0.47	medium_impact	-0.86	medium_impact	0.39	0.9	15.79	51.88	0.5	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13441	13441	A	G	MI.21620	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1105	369	T	A	Act/Gct	-5.33	0	0	probably_damaging	1	neutral	0.54	neutral	4.59	neutral	-2.75	deleterious	-4.49	medium_impact	3.33	0.61	neutral	0.13	damaging	3.52	23.10	deleterious	0.56	0.6	0.74	disease	0.46	neutral	0.7	disease	0.6	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.27	medium_impact	1.84	medium_impact	0.60	0.8	29.35	7.21	0.24	N	0.69	polymorphism	0.97	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13441	13441	A	C	MI.21621	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1105	369	T	P	Act/Cct	-5.33	0	0	probably_damaging	1	neutral	0.22	neutral	4.51	deleterious	-5.82	deleterious	-5.39	high_impact	3.63	0.61	neutral	0.12	damaging	3.50	23.10	deleterious	0.25	0.45	0.87	disease	0.71	disease	0.81	disease	0.83	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.07	medium_impact	2.11	high_impact	0.65	0.8	29.35	7.21	0.31	N	0.97	polymorphism	0.86	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13441	13441	A	T	MI.21622	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1105	369	T	S	Act/Tct	-5.33	0	0	probably_damaging	1	neutral	0.45	neutral	4.59	deleterious	-3.62	deleterious	-3.59	medium_impact	2.19	0.53	damaging	0.21	damaging	3.33	22.90	deleterious	0.44	0.55	0.86	disease	0.54	disease	0.6	disease	0.65	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.18	medium_impact	0.8	medium_impact	0.68	0.85	29.35	7.21	0.28	N	0.89	polymorphism	0.99	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13442	13442	C	A	MI.21623	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1106	369	T	N	aCt/aAt	6.81	1	0	probably_damaging	1	neutral	0.33	neutral	4.52	deleterious	-6	deleterious	-4.49	high_impact	4.22	0.5	damaging	0.11	damaging	3.68	23.30	deleterious	0.44	0.55	0.94	disease	0.68	disease	0.71	disease	0.78	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.06	medium_impact	2.65	high_impact	0.81	0.85	29.35	7.21	0.54	P	0.93	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13442	13442	C	T	MI.21624	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1106	369	T	I	aCt/aTt	6.81	1	0	probably_damaging	1	neutral	0.41	neutral	4.65	deleterious	-3.16	deleterious	-5.39	medium_impact	3.14	0.55	damaging	0.11	damaging	3.93	23.50	deleterious	0.47	0.55	0.66	disease	0.7	disease	0.69	disease	0.69	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.15	medium_impact	1.67	medium_impact	0.76	0.85	29.35	7.21	0.47	N	0.95	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13442	13442	C	G	MI.21625	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1106	369	T	S	aCt/aGt	6.81	1	0	probably_damaging	1	neutral	0.45	neutral	4.59	deleterious	-3.62	deleterious	-3.59	medium_impact	2.19	0.53	damaging	0.21	damaging	3.56	23.10	deleterious	0.44	0.55	0.86	disease	0.54	disease	0.6	disease	0.65	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.18	medium_impact	0.8	medium_impact	0.68	0.85	29.35	7.21	0.52	P	0.89	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13444	13444	T	G	MI.21626	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1108	370	S	A	Tca/Gca	-6.48	0	0	benign	0.18	neutral	0.54	neutral	4.78	neutral	1.95	neutral	-1.61	neutral_impact	0.69	0.8	neutral	0.86	neutral	2.63	20.40	deleterious	0.62	0.65	0.34	neutral	0.29	neutral	0.45	neutral	0.45	neutral	1	0.35	neutral	0.68	deleterious	-6	neutral	0.68	deleterious	-0.12	medium_impact	0.27	medium_impact	-0.57	medium_impact	0.71	0.85	16.75	19.08	0.3	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13444	13444	T	A	MI.21627	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1108	370	S	T	Tca/Aca	-6.48	0	0	benign	0.26	neutral	0.55	neutral	4.63	neutral	-0.72	neutral	-0.02	neutral_impact	0.69	0.79	neutral	0.96	neutral	2.18	17.39	deleterious	0.43	0.55	0.43	neutral	0.09	neutral	0.35	neutral	0.28	neutral	5	0.34	neutral	0.65	deleterious	-6	neutral	0.68	deleterious	-0.32	medium_impact	0.28	medium_impact	-0.57	medium_impact	0.82	0.85	16.75	19.08	0.36	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13444	13444	T	C	MI.21628	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1108	370	S	P	Tca/Cca	-6.48	0	0	probably_damaging	0.97	neutral	0.23	neutral	4.54	deleterious	-3.41	deleterious	-3.22	medium_impact	3.5	0.59	damaging	0.18	damaging	4.01	23.60	deleterious	0.29	0.45	0.51	disease	0.8	disease	0.76	disease	0.76	disease	5	0.98	neutral	0.13	neutral	1	deleterious	0.79	deleterious	-2.18	low_impact	-0.06	medium_impact	1.99	medium_impact	0.74	0.85	16.75	19.08	0.32	N	0.95	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13445	13445	C	T	MI.21629	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1109	370	S	L	tCa/tTa	0.17	0	0	possibly_damaging	0.81	neutral	0.8	neutral	4.61	neutral	-1.05	deleterious	-3.7	medium_impact	2.35	0.68	neutral	0.18	damaging	4.63	24.50	deleterious	0.43	0.55	0.69	disease	0.71	disease	0.62	disease	0.67	disease	3	0.78	neutral	0.5	deleterious	0	NA	0.77	deleterious	-1.34	low_impact	0.57	medium_impact	0.94	medium_impact	0.87	0.9	16.75	19.08	0.17	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6042	6042	C	A	MI.2163	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	139	47	L	I	Ctt/Att	-11.21	0	0	benign	0.31	deleterious	0.04	neutral	2.72	neutral	-2.79	neutral	-0.87	medium_impact	2.27	0.59	damaging	0.09	damaging	4.12	23.80	deleterious	0.42	0.55	0.41	neutral	0.59	disease	0.24	neutral	0.45	neutral	1	0.95	neutral	0.37	neutral	1	deleterious	0.30	neutral	-0.43	medium_impact	-0.58	medium_impact	1	medium_impact	0.55	0.9	2.92	7.3	0.34	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13445	13445	C	G	MI.21630	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1109	370	S	W	tCa/tGa	0.17	0	0	probably_damaging	1	neutral	0.19	neutral	4.53	neutral	-2.81	deleterious	-4.66	medium_impact	2.9	0.7	neutral	0.18	damaging	4.38	24.10	deleterious	0.23	0.45	0.85	disease	0.78	disease	0.7	disease	0.76	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	-0.12	medium_impact	1.45	medium_impact	0.46	0.8	16.75	19.08	0.25	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13447	13447	A	C	MI.21631	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1111	371	T	P	Acc/Ccc	-7.4	0	0	probably_damaging	0.92	neutral	0.2	neutral	4.48	deleterious	-3.49	deleterious	-2.91	medium_impact	3.12	0.63	neutral	0.33	neutral	3.99	23.60	deleterious	0.22	0.45	0.85	disease	0.82	disease	0.73	disease	0.82	disease	6	0.95	neutral	0.14	neutral	1	deleterious	0.86	deleterious	-1.75	low_impact	-0.1	medium_impact	1.65	medium_impact	0.64	0.8	17.25	12.94	0.27	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13447	13447	A	T	MI.21632	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1111	371	T	S	Acc/Tcc	-7.4	0	0	benign	0.12	neutral	0.53	neutral	4.55	neutral	-0.88	neutral	0.72	neutral_impact	-0.38	0.8	neutral	0.95	neutral	1.13	11.36	neutral	0.56	0.6	0.54	disease	0.06	neutral	0.28	neutral	0.27	neutral	5	0.38	neutral	0.71	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.26	medium_impact	-1.55	low_impact	0.67	0.85	17.25	12.94	0.35	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13447	13447	A	G	MI.21633	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1111	371	T	A	Acc/Gcc	-7.4	0	0	benign	0.08	neutral	0.5	neutral	4.59	neutral	0.81	neutral	-1.37	neutral_impact	-0.02	0.75	neutral	0.76	neutral	3.95	23.60	deleterious	0.74	0.75	0.48	neutral	0.26	neutral	0.43	neutral	0.42	neutral	2	0.44	neutral	0.71	deleterious	-6	neutral	0.70	deleterious	0.26	medium_impact	0.23	medium_impact	-1.22	low_impact	0.48	0.8	17.25	12.94	0.29	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13448	13448	C	A	MI.21634	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1112	371	T	N	aCc/aAc	-0.06	0	0	possibly_damaging	0.87	neutral	0.28	neutral	4.51	deleterious	-3.59	neutral	-1.42	medium_impact	3.47	0.73	neutral	0.53	neutral	3.82	23.40	deleterious	0.48	0.55	0.86	disease	0.66	disease	0.54	disease	0.66	disease	3	0.89	neutral	0.21	neutral	0	NA	0.80	deleterious	-1.53	low_impact	0.01	medium_impact	1.97	medium_impact	0.79	0.85	17.25	12.94	0.37	N	0.54	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13448	13448	C	T	MI.21635	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1112	371	T	I	aCc/aTc	-0.06	0	0	possibly_damaging	0.9	neutral	0.48	neutral	4.6	neutral	0.33	deleterious	-3.52	low_impact	0.84	0.84	neutral	0.56	neutral	3.95	23.60	deleterious	0.49	0.55	0.47	neutral	0.58	disease	0.6	disease	0.53	disease	1	0.89	neutral	0.29	neutral	-3	neutral	0.73	deleterious	-1.65	low_impact	0.21	medium_impact	-0.44	medium_impact	0.75	0.85	17.25	12.94	0.23	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13448	13448	C	G	MI.21636	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1112	371	T	S	aCc/aGc	-0.06	0	0	benign	0.12	neutral	0.53	neutral	4.55	neutral	-0.88	neutral	0.72	neutral_impact	-0.38	0.8	neutral	0.95	neutral	0.79	9.38	deleterious	0.56	0.6	0.54	disease	0.06	neutral	0.28	neutral	0.27	neutral	5	0.38	neutral	0.71	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.26	medium_impact	-1.55	low_impact	0.67	0.85	17.25	12.94	0.35	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13450	13450	T	A	MI.21637	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1114	372	S	T	Tcc/Acc	-11.29	0	0	possibly_damaging	0.86	neutral	0.53	neutral	4.65	neutral	1.1	neutral	-1.66	neutral_impact	-0.44	0.85	neutral	0.8	neutral	2.79	21.30	deleterious	0.45	0.55	0.41	neutral	0.21	neutral	0.48	neutral	0.4	neutral	2	0.84	neutral	0.34	neutral	-3	neutral	0.67	deleterious	-1.5	low_impact	0.26	medium_impact	-1.61	low_impact	0.76	0.85	22.55	15.56	0.29	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13450	13450	T	G	MI.21638	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1114	372	S	A	Tcc/Gcc	-11.29	0	0	benign	0.12	neutral	0.62	neutral	4.68	neutral	1.63	neutral	-0.33	neutral_impact	-0.68	0.84	neutral	0.99	neutral	1.54	13.53	neutral	0.51	0.6	0.35	neutral	0.14	neutral	0.35	neutral	0.29	neutral	4	0.28	neutral	0.75	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.35	medium_impact	-1.82	low_impact	0.71	0.85	22.55	15.56	0.38	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13450	13450	T	C	MI.21639	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1114	372	S	P	Tcc/Ccc	-11.29	0	0	probably_damaging	0.98	neutral	0.23	neutral	4.52	neutral	-2.91	deleterious	-3.1	medium_impact	2.2	0.52	damaging	0.36	neutral	4.03	23.70	deleterious	0.18	0.45	0.88	disease	0.8	disease	0.67	disease	0.82	disease	6	0.98	deleterious	0.13	neutral	1	deleterious	0.87	deleterious	-2.35	low_impact	-0.06	medium_impact	0.81	medium_impact	0.68	0.85	22.55	15.56	0.28	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6042	6042	C	T	MI.2164	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	139	47	L	F	Ctt/Ttt	-11.21	0	0	benign	0.02	neutral	0.18	neutral	2.87	neutral	-2.39	neutral	-1.21	low_impact	1.02	0.55	damaging	0.09	damaging	2.54	19.70	deleterious	0.39	0.55	0.32	neutral	0.42	neutral	0.21	neutral	0.45	neutral	1	0.81	neutral	0.58	deleterious	-6	neutral	0.21	neutral	0.83	medium_impact	-0.17	medium_impact	-0.16	medium_impact	0.40	0.9	2.92	7.3	0.4	N	0.87	polymorphism	1	0.02	rs878930535	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13451	13451	C	T	MI.21640	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1115	372	S	F	tCc/tTc	0.86	0.02	0	probably_damaging	0.98	neutral	0.78	neutral	4.55	neutral	0.04	deleterious	-3.82	neutral_impact	0.15	0.72	neutral	0.75	neutral	4.29	24.00	deleterious	0.33	0.5	0.57	disease	0.61	disease	0.57	disease	0.54	disease	1	0.97	neutral	0.4	neutral	-2	neutral	0.75	deleterious	-2.35	low_impact	0.54	medium_impact	-1.07	low_impact	0.53	0.8	22.55	15.56	0.23	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13451	13451	C	A	MI.21641	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1115	372	S	Y	tCc/tAc	0.86	0.02	0	probably_damaging	0.98	neutral	1	neutral	4.55	neutral	-2.07	deleterious	-3.79	neutral_impact	0.5	0.77	neutral	0.78	neutral	2.98	22.20	deleterious	0.25	0.45	0.75	disease	0.53	disease	0.52	disease	0.55	disease	1	0.98	deleterious	0.51	deleterious	-2	neutral	0.78	deleterious	-2.35	low_impact	1.89	high_impact	-0.75	medium_impact	0.77	0.85	22.55	15.56	0.21	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13451	13451	C	G	MI.21642	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1115	372	S	C	tCc/tGc	0.86	0.02	0	benign	0.33	neutral	0.22	neutral	4.6	neutral	-0.08	neutral	-1.64	neutral_impact	-1.68	0.77	neutral	0.95	neutral	0.93	10.28	neutral	0.3	0.45	0.43	neutral	0.12	neutral	0.22	neutral	0.3	neutral	4	0.74	neutral	0.45	neutral	-6	neutral	0.66	deleterious	-0.45	medium_impact	-0.07	medium_impact	-2.74	low_impact	0.63	0.8	22.55	15.56	0.41	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13453	13453	C	G	MI.21643	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1117	373	L	V	Ctc/Gtc	-4.87	0	0	possibly_damaging	0.9	neutral	0.52	neutral	4.29	neutral	-1.15	deleterious	-2.5	medium_impact	2.17	0.81	neutral	0.57	neutral	3.47	23.00	deleterious	0.36	0.5	0.68	disease	0.4	neutral	0.52	disease	0.63	disease	3	0.89	neutral	0.31	neutral	0	NA	0.73	deleterious	-1.65	low_impact	0.25	medium_impact	0.78	medium_impact	0.68	0.85	6.8	9.93	0.25	N	0.59	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13453	13453	C	A	MI.21644	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1117	373	L	I	Ctc/Atc	-4.87	0	0	possibly_damaging	0.9	neutral	0.44	neutral	4.37	neutral	-1.38	neutral	-1.63	neutral_impact	0.44	0.81	neutral	0.91	neutral	3.06	22.40	deleterious	0.33	0.5	0.53	disease	0.28	neutral	0.38	neutral	0.39	neutral	2	0.89	neutral	0.27	neutral	-3	neutral	0.70	deleterious	-1.65	low_impact	0.18	medium_impact	-0.8	medium_impact	0.80	0.85	6.8	9.93	0.3	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13453	13453	C	T	MI.21645	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1117	373	L	F	Ctc/Ttc	-4.87	0	0	probably_damaging	0.98	neutral	0.77	neutral	4.41	neutral	1.48	deleterious	-3.47	neutral_impact	-0.28	0.74	neutral	0.78	neutral	2.92	21.90	deleterious	0.39	0.5	0.35	neutral	0.41	neutral	0.41	neutral	0.44	neutral	1	0.98	neutral	0.4	neutral	-2	neutral	0.68	deleterious	-2.35	low_impact	0.52	medium_impact	-1.46	low_impact	0.66	0.8	6.8	9.93	0.28	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13454	13454	T	G	MI.21646	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1118	373	L	R	cTc/cGc	-1.89	0	0	probably_damaging	0.98	neutral	0.35	neutral	4.2	deleterious	-4.17	deleterious	-5.27	high_impact	3.65	0.63	neutral	0.31	neutral	4.23	23.90	deleterious	0.08	0.35	0.9	disease	0.8	disease	0.72	disease	0.79	disease	6	0.99	deleterious	0.19	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	0.08	medium_impact	2.13	high_impact	0.54	0.8	6.8	9.93	0.29	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13454	13454	T	A	MI.21647	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1118	373	L	H	cTc/cAc	-1.89	0	0	probably_damaging	1	neutral	0.54	neutral	4.19	deleterious	-4.65	deleterious	-6.14	high_impact	3.65	0.71	neutral	0.36	neutral	4.15	23.80	deleterious	0.09	0.4	0.93	disease	0.68	disease	0.69	disease	0.79	disease	6	0.99	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.27	medium_impact	2.13	high_impact	0.65	0.8	6.8	9.93	0.27	N	0.85	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13454	13454	T	C	MI.21648	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1118	373	L	P	cTc/cCc	-1.89	0	0	probably_damaging	1	neutral	0.28	neutral	4.19	deleterious	-4.33	deleterious	-6.14	high_impact	3.65	0.6	neutral	0.31	neutral	3.94	23.50	deleterious	0.08	0.35	0.93	disease	0.78	disease	0.71	disease	0.81	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.01	medium_impact	2.13	high_impact	0.51	0.8	6.8	9.93	0.3	N	0.92	polymorphism	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13456	13456	A	G	MI.21649	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1120	374	T	A	Acc/Gcc	-4.87	0	0	benign	0.01	neutral	0.53	neutral	4.66	neutral	0.1	neutral	-1.22	low_impact	1.25	0.78	neutral	0.79	neutral	0.49	7.39	deleterious	0.61	0.65	0.37	neutral	0.38	neutral	0.59	disease	0.49	neutral	0	0.46	neutral	0.76	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	0.26	medium_impact	-0.06	medium_impact	0.37	0.8	18.91	13.61	0.27	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6042	6042	C	G	MI.2165	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	139	47	L	V	Ctt/Gtt	-11.21	0	0	benign	0.14	deleterious	0.04	neutral	2.73	neutral	-2.78	neutral	-1.44	medium_impact	2.49	0.59	damaging	0.05	damaging	3.29	22.80	deleterious	0.43	0.55	0.38	neutral	0.61	disease	0.38	neutral	0.46	neutral	1	0.96	neutral	0.45	neutral	1	deleterious	0.25	neutral	-0.01	medium_impact	-0.58	medium_impact	1.2	medium_impact	0.40	0.9	2.92	7.3	0.3	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13456	13456	A	C	MI.21650	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1120	374	T	P	Acc/Ccc	-4.87	0	0	possibly_damaging	0.55	neutral	0.22	neutral	4.56	deleterious	-4.19	deleterious	-2.69	medium_impact	3.46	0.69	neutral	0.44	neutral	3.19	22.70	deleterious	0.21	0.45	0.89	disease	0.78	disease	0.73	disease	0.8	disease	6	0.77	neutral	0.34	neutral	0	NA	0.69	deleterious	-0.83	medium_impact	-0.07	medium_impact	1.96	medium_impact	0.55	0.8	18.91	13.61	0.32	N	0.83	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13456	13456	A	T	MI.21651	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1120	374	T	S	Acc/Tcc	-4.87	0	0	benign	0.18	neutral	0.64	neutral	4.66	neutral	-1.46	neutral	-1.6	low_impact	1.38	0.75	neutral	0.79	neutral	1.53	13.45	neutral	0.46	0.55	0.46	neutral	0.46	neutral	0.59	disease	0.49	neutral	0	0.24	neutral	0.73	deleterious	-6	neutral	0.29	neutral	-0.12	medium_impact	0.37	medium_impact	0.06	medium_impact	0.62	0.8	18.91	13.61	0.3	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13457	13457	C	G	MI.21652	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1121	374	T	S	aCc/aGc	3.15	0.03	0	benign	0.18	neutral	0.64	neutral	4.66	neutral	-1.46	neutral	-1.6	low_impact	1.38	0.75	neutral	0.79	neutral	1.73	14.55	neutral	0.46	0.55	0.46	neutral	0.46	neutral	0.59	disease	0.49	neutral	0	0.24	neutral	0.73	deleterious	-6	neutral	0.29	neutral	-0.12	medium_impact	0.37	medium_impact	0.06	medium_impact	0.62	0.8	18.91	13.61	0.33	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13457	13457	C	A	MI.21653	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1121	374	T	N	aCc/aAc	3.15	0.03	0	possibly_damaging	0.62	neutral	0.34	neutral	4.59	deleterious	-3.04	deleterious	-2.52	low_impact	1.6	0.73	neutral	0.62	neutral	3.49	23.10	deleterious	0.46	0.55	0.74	disease	0.62	disease	0.63	disease	0.61	disease	2	0.7	neutral	0.36	neutral	-3	neutral	0.63	deleterious	-0.95	medium_impact	0.07	medium_impact	0.26	medium_impact	0.80	0.85	18.91	13.61	0.31	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13457	13457	C	T	MI.21654	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1121	374	T	I	aCc/aTc	3.15	0.03	0	benign	0.01	neutral	0.64	neutral	4.77	neutral	-0.35	neutral	1.19	neutral_impact	0.66	0.83	neutral	0.97	neutral	0.00	2.62	deleterious	0.46	0.55	0.43	neutral	0.43	neutral	0.42	neutral	0.45	neutral	1	0.34	neutral	0.82	deleterious	-6	neutral	0.13	neutral	1.15	medium_impact	0.37	medium_impact	-0.6	medium_impact	0.68	0.85	18.91	13.61	0.32	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13459	13459	A	C	MI.21655	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1123	375	I	L	Att/Ctt	-9.46	0	0	possibly_damaging	0.61	neutral	0.74	neutral	4.65	neutral	-0.86	neutral	-1.73	neutral_impact	0.66	0.74	neutral	0.72	neutral	2.67	20.60	deleterious	0.39	0.5	0.41	neutral	0.3	neutral	0.39	neutral	0.42	neutral	2	0.53	neutral	0.57	deleterious	-3	neutral	0.64	deleterious	-0.93	medium_impact	0.48	medium_impact	-0.6	medium_impact	0.64	0.8	13.1	12.86	0.29	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13459	13459	A	G	MI.21656	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1123	375	I	V	Att/Gtt	-9.46	0	0	benign	0.12	neutral	0.53	neutral	4.56	neutral	-0.84	neutral	-0.59	low_impact	1.07	0.86	neutral	0.97	neutral	1.88	15.46	deleterious	0.5	0.6	0.49	neutral	0.17	neutral	0.45	neutral	0.24	neutral	5	0.38	neutral	0.71	deleterious	-6	neutral	0.62	deleterious	0.08	medium_impact	0.26	medium_impact	-0.23	medium_impact	0.55	0.8	13.1	12.86	0.35	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13459	13459	A	T	MI.21657	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1123	375	I	F	Att/Ttt	-9.46	0	0	probably_damaging	0.97	neutral	0.75	neutral	4.43	neutral	-2.7	deleterious	-3.49	medium_impact	2.91	0.63	neutral	0.37	neutral	4.09	23.70	deleterious	0.33	0.5	0.72	disease	0.6	disease	0.68	disease	0.66	disease	3	0.97	neutral	0.39	neutral	1	deleterious	0.75	deleterious	-2.18	low_impact	0.5	medium_impact	1.46	medium_impact	0.75	0.85	13.1	12.86	0.21	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13460	13460	T	A	MI.21658	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1124	375	I	N	aTt/aAt	0.86	0.1	0	probably_damaging	0.98	neutral	0.34	neutral	4.33	deleterious	-5.95	deleterious	-5.9	high_impact	4.47	0.64	neutral	0.41	neutral	4.41	24.10	deleterious	0.24	0.45	0.93	disease	0.67	disease	0.68	disease	0.79	disease	6	0.99	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-2.35	low_impact	0.07	medium_impact	2.88	high_impact	0.52	0.8	13.1	12.86	0.49	N	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13460	13460	T	G	MI.21659	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1124	375	I	S	aTt/aGt	0.86	0.1	0	probably_damaging	0.96	neutral	0.5	neutral	4.38	deleterious	-4.39	deleterious	-5	medium_impact	3.44	0.67	neutral	0.46	neutral	4.34	24.00	deleterious	0.28	0.45	0.78	disease	0.7	disease	0.65	disease	0.66	disease	3	0.95	neutral	0.27	neutral	1	deleterious	0.78	deleterious	-2.06	low_impact	0.23	medium_impact	1.94	medium_impact	0.50	0.8	13.1	12.86	0.34	N	0.90	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6043	6043	T	C	MI.2166	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	140	47	L	P	cTt/cCt	-0.11	0	0	probably_damaging	0.96	deleterious	0	neutral	2.59	deleterious	-5.45	deleterious	-3.74	high_impact	3.84	0.52	damaging	0.07	damaging	3.67	23.30	deleterious	0.22	0.55	0.84	disease	0.9	disease	0.42	neutral	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-2.06	low_impact	-1.48	low_impact	2.45	high_impact	0.34	0.9	2.92	7.3	0.33	N	0.83	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13460	13460	T	C	MI.21660	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1124	375	I	T	aTt/aCt	0.86	0.1	0	probably_damaging	0.91	neutral	0.52	neutral	4.4	deleterious	-3.68	deleterious	-3.87	medium_impact	1.96	0.76	neutral	0.94	neutral	2.23	17.74	deleterious	0.42	0.5	0.78	disease	0.43	neutral	0.59	disease	0.64	disease	3	0.9	neutral	0.31	neutral	1	deleterious	0.75	deleterious	-1.7	low_impact	0.25	medium_impact	0.59	medium_impact	0.54	0.8	13.1	12.86	0.34	N	0.82	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13461	13461	T	G	MI.21661	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1125	375	I	M	atT/atG	3.61	0.39	0.01	probably_damaging	0.97	neutral	0.25	neutral	4.38	deleterious	-3.64	neutral	-2.48	medium_impact	2.64	0.75	neutral	0.47	neutral	3.44	23.00	deleterious	0.37	0.5	0.67	disease	0.46	neutral	0.59	disease	0.63	disease	3	0.98	neutral	0.14	neutral	1	deleterious	0.72	deleterious	-2.18	low_impact	-0.03	medium_impact	1.21	medium_impact	0.73	0.85	13.1	12.86	0.36	N	0.69	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13461	13461	T	A	MI.21662	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1125	375	I	M	atT/atA	3.61	0.39	0.01	probably_damaging	0.97	neutral	0.25	neutral	4.38	deleterious	-3.64	neutral	-2.48	medium_impact	2.64	0.75	neutral	0.47	neutral	3.69	23.30	deleterious	0.37	0.5	0.67	disease	0.46	neutral	0.59	disease	0.63	disease	3	0.98	neutral	0.14	neutral	1	deleterious	0.72	deleterious	-2.18	low_impact	-0.03	medium_impact	1.21	medium_impact	0.73	0.85	13.1	12.86	0.36	N	0.69	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13462	13462	G	C	MI.21663	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1126	376	G	R	Ggc/Cgc	-6.02	0	0	probably_damaging	0.97	neutral	0.35	neutral	4.54	deleterious	-5.55	deleterious	-7.21	high_impact	4.61	0.56	damaging	0.22	damaging	3.87	23.50	deleterious	0.06	0.35	0.9	disease	0.83	disease	0.78	disease	0.84	disease	7	0.97	neutral	0.19	neutral	2	deleterious	0.86	deleterious	-2.18	low_impact	0.08	medium_impact	3.01	high_impact	0.64	0.8	19.24	7.09	0.48	N	0.97	polymorphism	0.7	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13462	13462	G	A	MI.21664	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1126	376	G	S	Ggc/Agc	-6.02	0	0	benign	0.42	neutral	0.41	neutral	4.6	deleterious	-3.06	deleterious	-5.4	low_impact	1.46	0.49	damaging	0.48	neutral	2.43	19.00	deleterious	0.21	0.45	0.56	disease	0.71	disease	0.58	disease	0.6	disease	2	0.54	neutral	0.5	deleterious	-6	neutral	0.41	neutral	-0.61	medium_impact	0.15	medium_impact	0.13	medium_impact	0.65	0.8	19.24	7.09	0.34	N	0.35	polymorphism	0.83	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13462	13462	G	T	MI.21665	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1126	376	G	C	Ggc/Tgc	-6.02	0	0	probably_damaging	0.99	neutral	0.18	neutral	4.55	deleterious	-3.94	deleterious	-8.11	medium_impact	3.02	0.53	damaging	0.21	damaging	4.13	23.80	deleterious	0.1	0.4	0.73	disease	0.83	disease	0.67	disease	0.71	disease	4	0.99	deleterious	0.1	neutral	1	deleterious	0.81	deleterious	-2.64	low_impact	-0.13	medium_impact	1.56	medium_impact	0.57	0.8	19.24	7.09	0.28	N	0.88	polymorphism	0.54	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13463	13463	G	C	MI.21666	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1127	376	G	A	gGc/gCc	4.06	1	0	benign	0.22	neutral	0.51	neutral	4.67	neutral	-0.35	deleterious	-5.4	neutral_impact	0.78	0.49	damaging	0.61	neutral	2.94	22.00	deleterious	0.44	0.55	0.49	neutral	0.43	neutral	0.56	disease	0.41	neutral	2	0.39	neutral	0.65	deleterious	-6	neutral	0.64	deleterious	-0.22	medium_impact	0.24	medium_impact	-0.49	medium_impact	0.71	0.85	19.24	7.09	0.5	N	0.75	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13463	13463	G	A	MI.21667	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1127	376	G	D	gGc/gAc	4.06	1	0	probably_damaging	0.96	neutral	0.2	neutral	4.52	deleterious	-6.47	deleterious	-6.3	high_impact	4.61	0.62	neutral	0.25	damaging	3.82	23.40	deleterious	0.08	0.35	0.93	disease	0.83	disease	0.77	disease	0.85	disease	7	0.97	neutral	0.12	neutral	2	deleterious	0.82	deleterious	-2.06	low_impact	-0.1	medium_impact	3.01	high_impact	0.34	0.8	19.24	7.09	0.58	P	0.85	disease_causing	1	0.32	.	.	.	.	.	.	COSM6188320	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13463	13463	G	T	MI.21668	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1127	376	G	V	gGc/gTc	4.06	1	0	probably_damaging	0.96	neutral	0.5	neutral	4.66	neutral	-2.94	deleterious	-8.11	high_impact	4.06	0.49	damaging	0.27	damaging	3.79	23.40	deleterious	0.1	0.4	0.72	disease	0.79	disease	0.67	disease	0.69	disease	4	0.95	neutral	0.27	neutral	2	deleterious	0.80	deleterious	-2.06	low_impact	0.23	medium_impact	2.51	high_impact	0.50	0.8	19.24	7.09	0.48	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13465	13465	A	C	MI.21669	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1129	377	S	R	Agc/Cgc	-5.56	0	0	possibly_damaging	0.83	neutral	0.35	neutral	4.53	deleterious	-4.08	deleterious	-4.19	high_impact	4.4	0.62	neutral	0.4	neutral	3.58	23.20	deleterious	0.17	0.45	0.88	disease	0.84	disease	0.74	disease	0.81	disease	6	0.85	neutral	0.26	neutral	1	deleterious	0.64	deleterious	-1.4	low_impact	0.08	medium_impact	2.82	high_impact	0.80	0.85	12.6	12.68	0.49	N	0.90	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6043	6043	T	A	MI.2167	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	140	47	L	H	cTt/cAt	-0.11	0	0	probably_damaging	0.94	deleterious	0.01	neutral	2.57	deleterious	-4.53	deleterious	-3.38	high_impact	3.58	0.59	damaging	0.04	damaging	3.97	23.60	deleterious	0.22	0.55	0.84	disease	0.85	disease	0.28	neutral	0.74	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.83	deleterious	-1.88	low_impact	-0.92	medium_impact	2.21	high_impact	0.40	0.9	2.92	7.3	0.26	N	0.83	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13465	13465	A	T	MI.21670	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1129	377	S	C	Agc/Tgc	-5.56	0	0	probably_damaging	0.98	neutral	0.18	neutral	4.59	neutral	-1.97	deleterious	-4.02	medium_impact	2.24	0.75	neutral	0.73	neutral	3.44	23.00	deleterious	0.21	0.45	0.71	disease	0.74	disease	0.55	disease	0.59	disease	2	0.98	deleterious	0.1	neutral	1	deleterious	0.73	deleterious	-2.35	low_impact	-0.13	medium_impact	0.84	medium_impact	0.73	0.85	12.6	12.68	0.3	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13465	13465	A	G	MI.21671	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1129	377	S	G	Agc/Ggc	-5.56	0	0	possibly_damaging	0.52	neutral	0.34	neutral	4.55	neutral	-0.81	deleterious	-3.39	low_impact	1.79	0.69	neutral	0.62	neutral	2.00	16.19	deleterious	0.43	0.55	0.59	disease	0.6	disease	0.6	disease	0.64	disease	3	0.64	neutral	0.41	neutral	-3	neutral	0.36	neutral	-0.78	medium_impact	0.07	medium_impact	0.43	medium_impact	0.59	0.8	12.6	12.68	0.29	N	0.50	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13466	13466	G	C	MI.21672	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1130	377	S	T	aGc/aCc	3.61	0.57	0	possibly_damaging	0.64	neutral	0.39	neutral	4.64	neutral	-0.35	neutral	-2.38	low_impact	1.58	0.75	neutral	0.84	neutral	1.77	14.79	neutral	0.4	0.5	0.38	neutral	0.4	neutral	0.54	disease	0.43	neutral	1	0.67	neutral	0.38	neutral	-3	neutral	0.39	neutral	-0.98	medium_impact	0.13	medium_impact	0.24	medium_impact	0.80	0.85	12.6	12.68	0.37	N	0.63	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13466	13466	G	A	MI.21673	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1130	377	S	N	aGc/aAc	3.61	0.57	0	benign	0.05	neutral	0.31	neutral	4.56	deleterious	-3.04	neutral	-2.34	low_impact	0.9	0.75	neutral	0.85	neutral	0.57	7.93	deleterious	0.61	0.65	0.69	disease	0.4	neutral	0.45	neutral	0.61	disease	2	0.66	neutral	0.63	deleterious	-6	neutral	0.21	neutral	0.47	medium_impact	0.04	medium_impact	-0.38	medium_impact	0.56	0.8	12.6	12.68	0.43	N	0.16	polymorphism	1	0.06	rs3902404	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13466	13466	G	T	MI.21674	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1130	377	S	I	aGc/aTc	3.61	0.57	0	probably_damaging	0.95	neutral	0.4	neutral	4.72	neutral	-0.92	deleterious	-4.97	medium_impact	2.96	0.63	neutral	0.48	neutral	4.06	23.70	deleterious	0.31	0.45	0.55	disease	0.84	disease	0.63	disease	0.71	disease	4	0.95	neutral	0.23	neutral	1	deleterious	0.70	deleterious	-1.96	low_impact	0.14	medium_impact	1.5	medium_impact	0.86	0.9	12.6	12.68	0.3	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13468	13468	C	G	MI.21675	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1132	378	L	V	Cta/Gta	-0.52	0	0	probably_damaging	0.92	neutral	0.56	neutral	4.23	deleterious	-3.17	deleterious	-2.65	medium_impact	2.85	0.69	neutral	0.44	neutral	3.48	23.10	deleterious	0.46	0.55	0.72	disease	0.48	neutral	0.67	disease	0.63	disease	3	0.91	neutral	0.32	neutral	1	deleterious	0.75	deleterious	-1.75	low_impact	0.29	medium_impact	1.4	medium_impact	0.75	0.85	3.98	7.99	0.24	N	0.81	polymorphism	1	0.11	rs28654395	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13468	13468	C	A	MI.21676	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1132	378	L	M	Cta/Ata	-0.52	0	0	probably_damaging	0.99	neutral	0.32	neutral	4.21	deleterious	-3.15	neutral	-1.72	low_impact	1.8	0.74	neutral	0.67	neutral	3.71	23.30	deleterious	0.34	0.5	0.69	disease	0.43	neutral	0.46	neutral	0.55	disease	1	0.99	deleterious	0.17	neutral	-2	neutral	0.72	deleterious	-2.64	low_impact	0.05	medium_impact	0.44	medium_impact	0.74	0.85	3.98	7.99	0.36	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13469	13469	T	G	MI.21677	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1133	378	L	R	cTa/cGa	-0.98	0	0	probably_damaging	0.99	neutral	0.35	neutral	4.15	deleterious	-6.47	deleterious	-5.32	high_impact	4.82	0.62	neutral	0.34	neutral	4.23	23.90	deleterious	0.21	0.45	0.91	disease	0.82	disease	0.77	disease	0.84	disease	7	0.99	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-2.64	low_impact	0.08	medium_impact	3.2	high_impact	0.52	0.8	3.98	7.99	0.71	P	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13469	13469	T	A	MI.21678	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1133	378	L	Q	cTa/cAa	-0.98	0	0	probably_damaging	1	neutral	0.28	neutral	4.14	deleterious	-6.65	deleterious	-5.31	high_impact	4.82	0.64	neutral	0.39	neutral	4.13	23.80	deleterious	0.21	0.45	0.95	disease	0.75	disease	0.67	disease	0.82	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.01	medium_impact	3.2	high_impact	0.70	0.85	3.98	7.99	0.64	P	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13469	13469	T	C	MI.21679	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1133	378	L	P	cTa/cCa	-0.98	0	0	probably_damaging	1	neutral	0.19	neutral	4.14	deleterious	-6.9	deleterious	-6.22	high_impact	4.82	0.62	neutral	0.36	neutral	3.96	23.60	deleterious	0.22	0.45	0.96	disease	0.74	disease	0.77	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.12	medium_impact	3.2	high_impact	0.59	0.8	3.98	7.99	0.63	P	0.99	polymorphism	0.94	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6043	6043	T	G	MI.2168	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	140	47	L	R	cTt/cGt	-0.11	0	0	possibly_damaging	0.88	deleterious	0	neutral	2.58	deleterious	-4.52	deleterious	-3.15	medium_impact	3.23	0.57	damaging	0.04	damaging	4.07	23.70	deleterious	0.3	0.55	0.79	disease	0.9	disease	0.49	neutral	0.76	disease	5	1	deleterious	0.06	neutral	4	deleterious	0.83	deleterious	-1.57	low_impact	-1.48	low_impact	1.88	medium_impact	0.51	0.9	2.92	7.3	0.24	N	0.90	polymorphism	0.97	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13471	13471	G	T	MI.21680	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1135	379	A	S	Gca/Tca	-5.33	0	0	probably_damaging	1	neutral	0.41	neutral	4.88	neutral	-0.69	deleterious	-2.5	low_impact	1.12	0.59	damaging	0.65	neutral	3.75	23.30	deleterious	0.47	0.55	0.43	neutral	0.58	disease	0.56	disease	0.45	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.15	medium_impact	-0.18	medium_impact	0.77	0.85	24.05	7.1	0.31	N	0.98	polymorphism	0.84	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13471	13471	G	C	MI.21681	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1135	379	A	P	Gca/Cca	-5.33	0	0	probably_damaging	1	neutral	0.19	neutral	4.45	deleterious	-6.23	deleterious	-4.34	high_impact	4.44	0.57	damaging	0.37	neutral	3.87	23.50	deleterious	0.17	0.45	0.95	disease	0.84	disease	0.78	disease	0.87	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.12	medium_impact	2.85	high_impact	0.67	0.85	24.05	7.1	0.5	N	0.96	disease_causing	0.61	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13471	13471	G	A	MI.21682	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1135	379	A	T	Gca/Aca	-5.33	0	0	probably_damaging	1	neutral	0.39	neutral	4.51	deleterious	-3.91	deleterious	-3.26	medium_impact	3.06	0.52	damaging	0.51	neutral	4.28	24.00	deleterious	0.35	0.5	0.8	disease	0.7	disease	0.61	disease	0.66	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.13	medium_impact	1.59	medium_impact	0.73	0.85	24.05	7.1	0.32	N	0.94	polymorphism	0.69	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13472	13472	C	A	MI.21683	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1136	379	A	E	gCa/gAa	9.11	1	0	probably_damaging	1	neutral	0.2	neutral	4.49	deleterious	-4.71	deleterious	-4.33	high_impact	4.79	0.58	damaging	0.4	neutral	4.64	24.50	deleterious	0.14	0.4	0.93	disease	0.84	disease	0.76	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.1	medium_impact	3.17	high_impact	0.64	0.8	24.05	7.1	0.75	P	0.99	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13472	13472	C	G	MI.21684	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1136	379	A	G	gCa/gGa	9.11	1	0	probably_damaging	1	neutral	0.4	neutral	4.49	deleterious	-3.47	deleterious	-3.5	medium_impact	2.97	0.6	damaging	0.52	neutral	3.96	23.60	deleterious	0.33	0.5	0.81	disease	0.69	disease	0.65	disease	0.69	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.14	medium_impact	1.51	medium_impact	0.75	0.85	24.05	7.1	0.53	P	0.82	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13472	13472	C	T	MI.21685	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1136	379	A	V	gCa/gTa	9.11	1	0	probably_damaging	1	neutral	0.47	neutral	4.5	deleterious	-4.64	deleterious	-3.46	high_impact	4.09	0.54	damaging	0.4	neutral	4.48	24.20	deleterious	0.39	0.5	0.76	disease	0.77	disease	0.66	disease	0.69	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.2	medium_impact	2.53	high_impact	0.68	0.85	24.05	7.1	0.61	P	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13474	13474	T	A	MI.21686	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1138	380	L	M	Tta/Ata	-5.1	0	0	probably_damaging	1	neutral	0.22	neutral	4.29	neutral	-1.99	neutral	-1.8	medium_impact	2.65	0.37	damaging	0.06	damaging	3.67	23.30	deleterious	0.42	0.55	0.8	disease	0.59	disease	0.66	disease	0.7	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.07	medium_impact	1.22	medium_impact	0.83	0.9	30.35	7.16	0.48	N	0.89	polymorphism	0.88	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13474	13474	T	G	MI.21687	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1138	380	L	V	Tta/Gta	-5.1	0	0	probably_damaging	1	neutral	0.5	neutral	4.32	deleterious	-3.33	deleterious	-2.7	high_impact	5.07	0.32	damaging	0.05	damaging	3.48	23.10	deleterious	0.42	0.55	0.81	disease	0.59	disease	0.69	disease	0.69	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.23	medium_impact	3.43	high_impact	0.64	0.8	30.35	7.16	0.61	P	0.81	polymorphism	0.86	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13475	13475	T	C	MI.21688	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1139	380	L	S	tTa/tCa	-1.21	0	0	probably_damaging	1	neutral	0.41	neutral	4.31	neutral	-2.67	deleterious	-5.41	high_impact	4.09	0.35	damaging	0.05	damaging	3.85	23.40	deleterious	0.26	0.45	0.7	disease	0.75	disease	0.69	disease	0.68	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.15	medium_impact	2.53	high_impact	0.60	0.8	30.35	7.16	0.47	N	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13475	13475	T	G	MI.21689	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1139	380	L	W	tTa/tGa	-1.21	0	0	probably_damaging	1	neutral	0.18	neutral	4.25	deleterious	-7.2	deleterious	-5.41	high_impact	5.07	0.34	damaging	0.03	damaging	3.83	23.40	deleterious	0.15	0.4	0.97	disease	0.7	disease	0.7	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.13	medium_impact	3.43	high_impact	0.58	0.8	30.35	7.16	0.55	P	0.98	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6045	6045	C	G	MI.2169	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	142	48	L	V	Cta/Gta	-6.81	0	0.02	benign	0.06	deleterious	0	neutral	2.47	neutral	-1.7	neutral	-0.51	medium_impact	2.29	0.63	neutral	0.46	neutral	1.42	12.91	neutral	0.46	0.55	0.3	neutral	0.59	disease	0.44	neutral	0.48	neutral	0	1	deleterious	0.47	deleterious	1	deleterious	0.20	neutral	0.37	medium_impact	-1.48	low_impact	1.02	medium_impact	0.47	0.9	11.5	34.61	0.44	N	0.33	polymorphism	1	0.01	rs879061193	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13476	13476	A	C	MI.21690	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1140	380	L	F	ttA/ttC	7.27	0.95	0	probably_damaging	1	neutral	0.72	neutral	4.33	deleterious	-3.97	deleterious	-3.6	high_impact	4.37	0.32	damaging	0.03	damaging	3.54	23.10	deleterious	0.42	0.55	0.82	disease	0.7	disease	0.69	disease	0.71	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.46	medium_impact	2.79	high_impact	0.73	0.85	30.35	7.16	0.64	P	0.99	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13476	13476	A	T	MI.21691	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1140	380	L	F	ttA/ttT	7.27	0.95	0	probably_damaging	1	neutral	0.72	neutral	4.33	deleterious	-3.97	deleterious	-3.6	high_impact	4.37	0.32	damaging	0.03	damaging	3.62	23.20	deleterious	0.42	0.55	0.82	disease	0.7	disease	0.69	disease	0.71	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.46	medium_impact	2.79	high_impact	0.73	0.85	30.35	7.16	0.66	P	0.99	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13477	13477	G	C	MI.21692	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1141	381	A	P	Gca/Cca	-1.89	0	0.01	possibly_damaging	0.81	neutral	0.26	neutral	4.51	deleterious	-6.03	neutral	-1.09	high_impact	3.52	0.63	neutral	0.37	neutral	3.67	23.20	deleterious	0.21	0.45	0.92	disease	0.86	disease	0.55	disease	0.84	disease	7	0.86	neutral	0.23	neutral	1	deleterious	0.77	deleterious	-1.34	low_impact	-0.02	medium_impact	2.01	high_impact	0.80	0.85	18.57	13.59	0.36	N	0.76	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13477	13477	G	A	MI.21693	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1141	381	A	T	Gca/Aca	-1.89	0	0.01	benign	0.01	neutral	0.56	neutral	4.59	neutral	-2.57	neutral	3.87	neutral_impact	0.78	0.83	neutral	0.93	neutral	-0.37	0.45	neutral	0.66	0.7	0.54	disease	0.06	neutral	0.2	neutral	0.32	neutral	4	0.42	neutral	0.78	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.29	medium_impact	-0.49	medium_impact	0.73	0.85	18.57	13.59	0.36	N	0.04	polymorphism	1	0.01	rs200283691	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13477	13477	G	T	MI.21694	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1141	381	A	S	Gca/Tca	-1.89	0	0.01	benign	0.36	neutral	0.52	neutral	4.65	neutral	-2.17	neutral	0.69	neutral_impact	0.52	0.77	neutral	0.77	neutral	2.04	16.44	deleterious	0.6	0.65	0.54	disease	0.47	neutral	0.43	neutral	0.51	disease	0	0.4	neutral	0.58	deleterious	-6	neutral	0.37	neutral	-0.51	medium_impact	0.25	medium_impact	-0.73	medium_impact	0.87	0.9	18.57	13.59	0.32	N	0.53	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13478	13478	C	G	MI.21695	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1142	381	A	G	gCa/gGa	2.46	0.01	0	possibly_damaging	0.44	neutral	0.48	neutral	4.61	deleterious	-3.78	neutral	-1.89	low_impact	1.82	0.75	neutral	0.62	neutral	2.32	18.29	deleterious	0.4	0.5	0.66	disease	0.54	disease	0.54	disease	0.64	disease	3	0.48	neutral	0.52	deleterious	-3	neutral	0.46	deleterious	-0.65	medium_impact	0.21	medium_impact	0.46	medium_impact	0.79	0.85	18.57	13.59	0.33	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13478	13478	C	T	MI.21696	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1142	381	A	V	gCa/gTa	2.46	0.01	0	benign	0.36	neutral	0.59	neutral	4.62	neutral	-2.04	neutral	-0.13	low_impact	0.98	0.83	neutral	0.78	neutral	2.65	20.50	deleterious	0.58	0.65	0.58	disease	0.59	disease	0.37	neutral	0.5	disease	0	0.34	neutral	0.62	deleterious	-6	neutral	0.32	neutral	-0.51	medium_impact	0.32	medium_impact	-0.31	medium_impact	0.75	0.85	18.57	13.59	0.29	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13478	13478	C	A	MI.21697	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1142	381	A	E	gCa/gAa	2.46	0.01	0	possibly_damaging	0.56	neutral	0.26	neutral	4.51	deleterious	-6.03	neutral	-1.08	high_impact	3.52	0.72	neutral	0.59	neutral	2.98	22.20	deleterious	0.2	0.45	0.91	disease	0.8	disease	0.67	disease	0.83	disease	7	0.74	neutral	0.35	neutral	1	deleterious	0.64	deleterious	-0.85	medium_impact	-0.02	medium_impact	2.01	high_impact	0.71	0.85	18.57	13.59	0.37	N	0.78	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13480	13480	G	C	MI.21698	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1144	382	G	R	Gga/Cga	-0.29	0	0	probably_damaging	1	neutral	0.35	neutral	3.6	deleterious	-9.94	deleterious	-7.21	high_impact	4.84	0.36	damaging	0.03	damaging	4.02	23.60	deleterious	0.14	0.4	0.99	disease	0.92	disease	0.83	disease	0.89	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.08	medium_impact	3.22	high_impact	0.71	0.85	27.36	7.2	0.52	P	1.00	disease_causing	0.77	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13480	13480	G	T	MI.21699	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1144	382	G	W	Gga/Tga	-0.29	0	0	probably_damaging	1	neutral	0.18	neutral	3.58	deleterious	-12.72	deleterious	-7.21	high_impact	5.18	0.34	damaging	0.02	damaging	4.48	24.20	deleterious	0.18	0.45	1	disease	0.9	disease	0.78	disease	0.88	disease	8	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.13	medium_impact	3.53	high_impact	0.34	0.8	27.36	7.2	0.47	P	1.00	disease_causing	0.85	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8627	8627	C	T	MI.217	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	101	34	S	F	tCc/tTc	0.59	0	0	probably_damaging	1	neutral	0.7	neutral	4.26	deleterious	-3.23	deleterious	-3.97	low_impact	0.94	0.82	neutral	0.15	damaging	4.11	23.70	deleterious	0.36	0.65	0.82	disease	0.7	disease	0.61	disease	0.68	disease	4	1	deleterious	0.35	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	0.5	medium_impact	-0.29	medium_impact	0.39	0.9	9.73	14.65	0.19	N	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6045	6045	C	A	MI.2170	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	142	48	L	M	Cta/Ata	-6.81	0	0.02	benign	0.03	deleterious	0.02	neutral	2.36	deleterious	-3.06	neutral	-0.79	low_impact	1.54	0.69	neutral	0.72	neutral	2.42	18.93	deleterious	0.35	0.55	0.55	disease	0.43	neutral	0.23	neutral	0.61	disease	2	0.98	neutral	0.5	deleterious	-2	neutral	0.21	neutral	0.66	medium_impact	-0.75	medium_impact	0.32	medium_impact	0.71	0.9	11.5	34.61	0.46	N	0.38	polymorphism	1	0.02	rs879061193	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13481	13481	G	T	MI.21700	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1145	382	G	V	gGa/gTa	9.11	1	0	probably_damaging	1	neutral	0.51	neutral	3.61	deleterious	-8.79	deleterious	-8.11	high_impact	5.18	0.33	damaging	0.03	damaging	3.79	23.40	deleterious	0.16	0.45	0.93	disease	0.9	disease	0.77	disease	0.84	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.24	medium_impact	3.53	high_impact	0.57	0.8	27.36	7.2	0.63	P	0.98	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13481	13481	G	C	MI.21701	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1145	382	G	A	gGa/gCa	9.11	1	0	probably_damaging	1	neutral	0.52	neutral	3.82	deleterious	-4.42	deleterious	-5.41	medium_impact	3.18	0.4	damaging	0.06	damaging	3.16	22.60	deleterious	0.24	0.45	0.59	disease	0.7	disease	0.7	disease	0.7	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.25	medium_impact	1.7	medium_impact	0.50	0.8	27.36	7.2	0.61	P	0.79	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13481	13481	G	A	MI.21702	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1145	382	G	E	gGa/gAa	9.11	1	0	probably_damaging	1	neutral	0.28	neutral	3.6	deleterious	-10.01	deleterious	-7.21	high_impact	5.18	0.27	damaging	0.02	damaging	3.94	23.50	deleterious	0.17	0.45	0.99	disease	0.88	disease	0.83	disease	0.89	disease	8	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.01	medium_impact	3.53	high_impact	0.71	0.85	27.36	7.2	0.73	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13483	13483	A	C	MI.21703	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1147	383	M	L	Ata/Cta	-4.42	0	0	benign	0.08	neutral	0.65	neutral	4.93	neutral	2.6	neutral	-1.73	neutral_impact	-0.16	0.75	neutral	0.64	neutral	1.48	13.19	neutral	0.43	0.55	0.38	neutral	0.74	disease	0.65	disease	0.58	disease	2	0.26	neutral	0.79	deleterious	-6	neutral	0.22	neutral	0.26	medium_impact	0.38	medium_impact	-1.35	low_impact	0.63	0.8	8.96	10.68	0.29	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13483	13483	A	G	MI.21704	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1147	383	M	V	Ata/Gta	-4.42	0	0	benign	0.02	neutral	0.5	neutral	4.7	neutral	1.27	neutral	-2.02	neutral_impact	0.4	0.89	neutral	0.86	neutral	-0.14	1.44	neutral	0.5	0.6	0.35	neutral	0.71	disease	0.58	disease	0.54	disease	1	0.48	neutral	0.74	deleterious	-6	neutral	0.21	neutral	0.86	medium_impact	0.23	medium_impact	-0.84	medium_impact	0.71	0.85	8.96	10.68	0.27	N	0.84	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13483	13483	A	T	MI.21705	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1147	383	M	L	Ata/Tta	-4.42	0	0	benign	0.08	neutral	0.65	neutral	4.93	neutral	2.6	neutral	-1.73	neutral_impact	-0.16	0.75	neutral	0.64	neutral	1.58	13.75	neutral	0.43	0.55	0.38	neutral	0.74	disease	0.65	disease	0.58	disease	2	0.26	neutral	0.79	deleterious	-6	neutral	0.22	neutral	0.26	medium_impact	0.38	medium_impact	-1.35	low_impact	0.63	0.8	8.96	10.68	0.29	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13484	13484	T	C	MI.21706	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1148	383	M	T	aTa/aCa	4.52	0.24	0	benign	0.02	neutral	0.4	neutral	4.67	neutral	-0.81	deleterious	-2.61	neutral_impact	-0.12	0.77	neutral	0.93	neutral	-1.39	0.00	neutral	0.53	0.6	0.52	disease	0.16	neutral	0.34	neutral	0.21	neutral	6	0.59	neutral	0.69	deleterious	-6	neutral	0.35	neutral	0.86	medium_impact	0.14	medium_impact	-1.31	low_impact	0.54	0.8	8.96	10.68	0.38	N	0.61	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13484	13484	T	A	MI.21707	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1148	383	M	K	aTa/aAa	4.52	0.24	0	possibly_damaging	0.46	neutral	0.29	neutral	4.6	neutral	-2.99	deleterious	-3.99	medium_impact	3.29	0.7	neutral	0.41	neutral	2.59	20.20	deleterious	0.2	0.45	0.83	disease	0.88	disease	0.73	disease	0.83	disease	7	0.67	neutral	0.42	neutral	0	NA	0.67	deleterious	-0.68	medium_impact	0.02	medium_impact	1.8	medium_impact	0.44	0.8	8.96	10.68	0.38	N	0.96	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13485	13485	A	C	MI.21708	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1149	383	M	I	atA/atC	0.17	0.02	0	benign	0.02	neutral	0.39	neutral	4.91	neutral	2.37	neutral	-2.15	neutral_impact	-0.07	0.84	neutral	0.96	neutral	0.39	6.57	deleterious	0.46	0.55	0.36	neutral	0.7	disease	0.45	neutral	0.53	disease	1	0.59	neutral	0.69	deleterious	-6	neutral	0.20	neutral	0.86	medium_impact	0.13	medium_impact	-1.27	low_impact	0.71	0.85	8.96	10.68	0.31	N	0.84	polymorphism	1	0.02	rs28359176	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13485	13485	A	T	MI.21709	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1149	383	M	I	atA/atT	0.17	0.02	0	benign	0.02	neutral	0.39	neutral	4.91	neutral	2.37	neutral	-2.15	neutral_impact	-0.07	0.84	neutral	0.96	neutral	0.47	7.18	deleterious	0.46	0.55	0.36	neutral	0.7	disease	0.45	neutral	0.53	disease	1	0.59	neutral	0.69	deleterious	-6	neutral	0.20	neutral	0.86	medium_impact	0.13	medium_impact	-1.27	low_impact	0.71	0.85	8.96	10.68	0.31	N	0.84	polymorphism	1	0.02	rs28359176	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6046	6046	T	G	MI.2171	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	143	48	L	R	cTa/cGa	-2.88	0	0	possibly_damaging	0.67	deleterious	0	neutral	2.31	deleterious	-4.82	deleterious	-3.31	high_impact	3.53	0.62	neutral	0.32	neutral	3.97	23.60	deleterious	0.28	0.55	0.49	neutral	0.89	disease	0.7	disease	0.81	disease	6	1	deleterious	0.17	neutral	5	deleterious	0.68	deleterious	-1.05	low_impact	-1.48	low_impact	2.16	high_impact	0.67	0.9	11.5	34.61	0.3	N	0.93	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13486	13486	C	G	MI.21710	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1150	384	P	A	Cct/Gct	-6.94	0	0	probably_damaging	1	neutral	0.56	neutral	3.56	deleterious	-6.53	deleterious	-7.18	high_impact	4.04	0.3	damaging	0.54	neutral	3.13	22.60	deleterious	0.19	0.45	0.95	disease	0.72	disease	0.77	disease	0.84	disease	7	1	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.29	medium_impact	2.49	high_impact	0.63	0.8	28.69	7.27	0.61	P	0.73	polymorphism	0.68	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13486	13486	C	T	MI.21711	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1150	384	P	S	Cct/Tct	-6.94	0	0	probably_damaging	1	neutral	0.45	neutral	3.54	deleterious	-7.27	deleterious	-7.18	high_impact	4.63	0.31	damaging	0.58	neutral	3.96	23.60	deleterious	0.26	0.45	0.95	disease	0.85	disease	0.76	disease	0.85	disease	7	1	deleterious	0.23	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.18	medium_impact	3.03	high_impact	0.37	0.8	28.69	7.27	0.69	P	0.78	polymorphism	0.56	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13486	13486	C	A	MI.21712	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1150	384	P	T	Cct/Act	-6.94	0	0	probably_damaging	1	neutral	0.47	neutral	3.54	deleterious	-7.12	deleterious	-7.18	high_impact	4.63	0.31	damaging	0.42	neutral	3.76	23.30	deleterious	0.22	0.45	0.96	disease	0.84	disease	0.77	disease	0.86	disease	7	1	deleterious	0.24	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.2	medium_impact	3.03	high_impact	0.65	0.8	28.69	7.27	0.65	P	0.91	polymorphism	0.57	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13487	13487	C	T	MI.21713	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1151	384	P	L	cCt/cTt	5.44	1	0	probably_damaging	1	neutral	0.85	neutral	3.62	deleterious	-6.14	deleterious	-8.98	high_impact	3.83	0.19	damaging	0.44	neutral	4.35	24.10	deleterious	0.25	0.45	0.82	disease	0.9	disease	0.74	disease	0.8	disease	6	1	deleterious	0.43	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.65	medium_impact	2.3	high_impact	0.79	0.85	28.69	7.27	0.87	P	0.97	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13487	13487	C	A	MI.21714	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1151	384	P	H	cCt/cAt	5.44	1	0	probably_damaging	1	neutral	0.53	neutral	3.52	deleterious	-8.86	deleterious	-8.08	high_impact	5.18	0.31	damaging	0.37	neutral	4.11	23.70	deleterious	0.21	0.45	0.97	disease	0.88	disease	0.83	disease	0.85	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.26	medium_impact	3.53	high_impact	0.58	0.8	28.69	7.27	0.73	P	0.72	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13487	13487	C	G	MI.21715	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1151	384	P	R	cCt/cGt	5.44	1	0	probably_damaging	1	neutral	0.36	neutral	3.53	deleterious	-8.31	deleterious	-8.08	high_impact	5.18	0.34	damaging	0.41	neutral	3.61	23.20	deleterious	0.18	0.45	0.98	disease	0.92	disease	0.85	disease	0.87	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.1	medium_impact	3.53	high_impact	0.62	0.8	28.69	7.27	0.73	P	0.64	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13489	13489	T	C	MI.21716	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1153	385	F	L	Ttc/Ctc	-12.21	0	0	probably_damaging	1	neutral	0.73	neutral	4.69	neutral	0.53	deleterious	-5.24	medium_impact	2.85	0.62	neutral	0.59	neutral	4.14	23.80	deleterious	0.5	0.6	0.5	neutral	0.8	disease	0.64	disease	0.64	disease	3	1	deleterious	0.37	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.47	medium_impact	1.4	medium_impact	0.84	0.9	18.24	7.04	0.28	N	0.92	polymorphism	0.85	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13489	13489	T	A	MI.21717	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1153	385	F	I	Ttc/Atc	-12.21	0	0	probably_damaging	1	neutral	0.39	neutral	4.63	neutral	-1.33	deleterious	-5.26	high_impact	3.79	0.64	neutral	0.62	neutral	4.47	24.20	deleterious	0.26	0.45	0.59	disease	0.82	disease	0.72	disease	0.73	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.13	medium_impact	2.26	high_impact	0.74	0.85	18.24	7.04	0.38	N	0.95	polymorphism	0.86	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13489	13489	T	G	MI.21718	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1153	385	F	V	Ttc/Gtc	-12.21	0	0	probably_damaging	1	neutral	0.51	neutral	4.63	neutral	-1.24	deleterious	-6.12	high_impact	3.86	0.65	neutral	0.53	neutral	4.21	23.90	deleterious	0.42	0.55	0.55	disease	0.87	disease	0.71	disease	0.77	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.24	medium_impact	2.32	high_impact	0.60	0.8	18.24	7.04	0.34	N	0.95	polymorphism	0.75	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13490	13490	T	C	MI.21719	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1154	385	F	S	tTc/tCc	7.27	1	0	probably_damaging	1	neutral	0.44	neutral	4.57	neutral	-2.55	deleterious	-7.04	high_impact	4.28	0.68	neutral	0.59	neutral	4.27	24.00	deleterious	0.33	0.5	0.74	disease	0.86	disease	0.71	disease	0.75	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.18	medium_impact	2.71	high_impact	0.57	0.8	18.24	7.04	0.63	P	0.97	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6046	6046	T	C	MI.2172	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	143	48	L	P	cTa/cCa	-2.88	0	0	possibly_damaging	0.9	deleterious	0	neutral	2.31	deleterious	-4.6	deleterious	-3.61	high_impact	3.88	0.61	neutral	0.36	neutral	3.72	23.30	deleterious	0.21	0.55	0.65	disease	0.9	disease	0.56	disease	0.78	disease	6	1	deleterious	0.05	neutral	5	deleterious	0.86	deleterious	-1.65	low_impact	-1.48	low_impact	2.48	high_impact	0.55	0.9	11.5	34.61	0.37	N	0.83	polymorphism	0.88	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13490	13490	T	G	MI.21720	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1154	385	F	C	tTc/tGc	7.27	1	0	probably_damaging	1	neutral	0.17	neutral	4.53	deleterious	-3.97	deleterious	-7.03	high_impact	4.83	0.65	neutral	0.49	neutral	4.12	23.80	deleterious	0.32	0.5	0.88	disease	0.88	disease	0.73	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.15	medium_impact	3.21	high_impact	0.38	0.8	18.24	7.04	0.71	P	0.99	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13490	13490	T	A	MI.21721	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1154	385	F	Y	tTc/tAc	7.27	1	0	probably_damaging	1	neutral	1	neutral	4.56	neutral	-2.52	neutral	-2.43	medium_impact	2.4	0.78	neutral	0.88	neutral	4.23	23.90	deleterious	0.29	0.45	0.67	disease	0.69	disease	0.66	disease	0.51	disease	0	1	deleterious	0.5	deleterious	1	deleterious	0.79	deleterious	-3.6	low_impact	1.89	high_impact	0.99	medium_impact	0.68	0.85	18.24	7.04	0.5	N	0.88	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13491	13491	C	G	MI.21722	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1155	385	F	L	ttC/ttG	3.61	1	0	probably_damaging	1	neutral	0.73	neutral	4.69	neutral	0.53	deleterious	-5.24	medium_impact	2.85	0.62	neutral	0.59	neutral	4.45	24.20	deleterious	0.5	0.6	0.5	neutral	0.8	disease	0.64	disease	0.64	disease	3	1	deleterious	0.37	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.47	medium_impact	1.4	medium_impact	0.84	0.9	18.24	7.04	0.39	N	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13491	13491	C	A	MI.21723	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1155	385	F	L	ttC/ttA	3.61	1	0	probably_damaging	1	neutral	0.73	neutral	4.69	neutral	0.53	deleterious	-5.24	medium_impact	2.85	0.62	neutral	0.59	neutral	4.78	24.70	deleterious	0.5	0.6	0.5	neutral	0.8	disease	0.64	disease	0.64	disease	3	1	deleterious	0.37	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.47	medium_impact	1.4	medium_impact	0.84	0.9	18.24	7.04	0.4	N	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13492	13492	C	G	MI.21724	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1156	386	L	V	Ctc/Gtc	-1.21	0	0	benign	0.22	neutral	0.49	neutral	4.36	neutral	-2.78	deleterious	-2.7	high_impact	3.63	0.48	damaging	0.44	neutral	1.59	13.78	neutral	0.48	0.55	0.74	disease	0.69	disease	0.72	disease	0.72	disease	4	0.41	neutral	0.64	deleterious	-2	neutral	0.28	neutral	-0.22	medium_impact	0.22	medium_impact	2.11	high_impact	0.69	0.85	26.53	7.19	0.4	N	0.81	disease_causing	0.97	0.10	rs28376363	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13492	13492	C	T	MI.21725	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1156	386	L	F	Ctc/Ttc	-1.21	0	0	probably_damaging	0.98	neutral	0.84	neutral	4.35	neutral	-0.33	deleterious	-3.6	low_impact	1.74	0.54	damaging	0.46	neutral	3.96	23.60	deleterious	0.39	0.5	0.54	disease	0.73	disease	0.7	disease	0.59	disease	2	0.98	neutral	0.43	neutral	-2	neutral	0.73	deleterious	-2.35	low_impact	0.63	medium_impact	0.39	medium_impact	0.68	0.85	26.53	7.19	0.26	N	0.99	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13492	13492	C	A	MI.21726	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1156	386	L	I	Ctc/Atc	-1.21	0	0	possibly_damaging	0.68	neutral	0.38	neutral	4.31	deleterious	-3.24	neutral	-1.8	medium_impact	3.45	0.56	damaging	0.55	neutral	2.52	19.60	deleterious	0.34	0.5	0.79	disease	0.71	disease	0.71	disease	0.75	disease	5	0.71	neutral	0.35	neutral	0	NA	0.44	deleterious	-1.06	low_impact	0.12	medium_impact	1.95	medium_impact	0.73	0.85	26.53	7.19	0.33	N	0.85	disease_causing	0.94	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13493	13493	T	G	MI.21727	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1157	386	L	R	cTc/cGc	-0.06	0	0	probably_damaging	0.99	neutral	0.35	neutral	4.26	deleterious	-5.56	deleterious	-5.39	high_impact	4.49	0.58	damaging	0.34	neutral	4.19	23.80	deleterious	0.17	0.45	0.92	disease	0.91	disease	0.8	disease	0.87	disease	7	0.99	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-2.64	low_impact	0.08	medium_impact	2.9	high_impact	0.57	0.8	26.53	7.19	0.53	N	1.00	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13493	13493	T	C	MI.21728	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1157	386	L	P	cTc/cCc	-0.06	0	0	probably_damaging	0.99	neutral	0.25	neutral	4.25	deleterious	-5.82	deleterious	-6.29	high_impact	4.49	0.53	damaging	0.37	neutral	3.93	23.50	deleterious	0.19	0.45	0.95	disease	0.83	disease	0.7	disease	0.84	disease	7	0.99	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-2.64	low_impact	-0.03	medium_impact	2.9	high_impact	0.63	0.8	26.53	7.19	0.4	N	0.99	disease_causing	1	0.32	.	.	.	.	.	oncocytoma	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13493	13493	T	A	MI.21729	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1157	386	L	H	cTc/cAc	-0.06	0	0	probably_damaging	0.99	neutral	0.5	neutral	4.25	deleterious	-6.08	deleterious	-6.29	high_impact	4.84	0.55	damaging	0.37	neutral	4.16	23.80	deleterious	0.2	0.45	0.94	disease	0.83	disease	0.78	disease	0.87	disease	7	0.99	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-2.64	low_impact	0.23	medium_impact	3.22	high_impact	0.66	0.8	26.53	7.19	0.68	P	0.97	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6046	6046	T	A	MI.2173	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	143	48	L	Q	cTa/cAa	-2.88	0	0	possibly_damaging	0.67	deleterious	0	neutral	2.3	deleterious	-5	deleterious	-3.29	high_impact	3.53	0.67	neutral	0.43	neutral	3.85	23.40	deleterious	0.26	0.55	0.48	neutral	0.77	disease	0.57	disease	0.71	disease	4	1	deleterious	0.17	neutral	5	deleterious	0.63	deleterious	-1.05	low_impact	-1.48	low_impact	2.16	high_impact	0.62	0.9	11.5	34.61	0.37	N	0.80	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13495	13495	A	T	MI.21730	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1159	387	T	S	Aca/Tca	-3.5	0	0	benign	0.2	neutral	0.43	neutral	4.68	neutral	1.95	deleterious	-3.44	neutral_impact	-1.53	0.73	neutral	0.6	neutral	0.19	4.53	deleterious	0.53	0.6	0.33	neutral	0.35	neutral	0.39	neutral	0.45	neutral	1	0.48	neutral	0.62	deleterious	-6	neutral	0.20	neutral	-0.17	medium_impact	0.17	medium_impact	-2.6	low_impact	0.84	0.9	14.59	15.42	0.33	N	0.12	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13495	13495	A	G	MI.21731	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1159	387	T	A	Aca/Gca	-3.5	0	0	benign	0.13	neutral	0.51	neutral	4.7	neutral	1.65	deleterious	-4.21	neutral_impact	-1.3	0.72	neutral	0.82	neutral	-0.87	0.03	neutral	0.58	0.65	0.35	neutral	0.09	neutral	0.34	neutral	0.22	neutral	6	0.4	neutral	0.69	deleterious	-6	neutral	0.41	neutral	0.04	medium_impact	0.24	medium_impact	-2.39	low_impact	0.49	0.8	14.59	15.42	0.39	N	0.45	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13495	13495	A	C	MI.21732	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1159	387	T	P	Aca/Cca	-3.5	0	0	probably_damaging	0.96	neutral	0.21	neutral	4.52	neutral	-1.93	deleterious	-5.24	medium_impact	2.29	0.65	neutral	0.32	neutral	3.45	23.00	deleterious	0.21	0.45	0.7	disease	0.91	disease	0.64	disease	0.79	disease	6	0.97	neutral	0.13	neutral	1	deleterious	0.84	deleterious	-2.06	low_impact	-0.09	medium_impact	0.89	medium_impact	0.65	0.8	14.59	15.42	0.26	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13496	13496	C	T	MI.21733	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1160	387	T	M	aCa/aTa	1.77	0.97	0	probably_damaging	0.98	neutral	0.23	neutral	4.57	neutral	-1.77	deleterious	-5.24	medium_impact	2.29	0.77	neutral	0.48	neutral	4.07	23.70	deleterious	0.3	0.45	0.82	disease	0.76	disease	0.67	disease	0.77	disease	5	0.99	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-2.35	low_impact	-0.06	medium_impact	0.89	medium_impact	0.75	0.85	14.59	15.42	0.32	N	0.88	polymorphism	0.88	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13496	13496	C	A	MI.21734	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1160	387	T	K	aCa/aAa	1.77	0.97	0	possibly_damaging	0.83	neutral	0.29	neutral	4.53	neutral	-2.28	deleterious	-5.24	medium_impact	2.85	0.71	neutral	0.39	neutral	4.18	23.80	deleterious	0.2	0.45	0.66	disease	0.89	disease	0.74	disease	0.82	disease	6	0.87	neutral	0.23	neutral	0	NA	0.71	deleterious	-1.4	low_impact	0.02	medium_impact	1.4	medium_impact	0.73	0.85	14.59	15.42	0.42	N	0.85	polymorphism	0.81	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13498	13498	G	T	MI.21735	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1162	388	G	C	Ggt/Tgt	-0.29	0.49	0	probably_damaging	1	neutral	0.19	neutral	4.21	deleterious	-7.14	deleterious	-8.09	high_impact	3.79	0.31	damaging	0.05	damaging	4.24	23.90	deleterious	0.12	0.4	0.88	disease	0.91	disease	0.79	disease	0.82	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.12	medium_impact	2.26	high_impact	0.62	0.8	29.52	7.17	0.57	P	0.97	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13498	13498	G	C	MI.21736	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1162	388	G	R	Ggt/Cgt	-0.29	0.49	0	probably_damaging	1	neutral	0.35	neutral	4.24	deleterious	-6.84	deleterious	-7.19	high_impact	4.83	0.35	damaging	0.03	damaging	4.07	23.70	deleterious	0.11	0.4	0.93	disease	0.93	disease	0.86	disease	0.88	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.94	deleterious	-3.6	low_impact	0.08	medium_impact	3.21	high_impact	0.71	0.85	29.52	7.17	0.62	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13498	13498	G	A	MI.21737	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1162	388	G	S	Ggt/Agt	-0.29	0.49	0	probably_damaging	1	neutral	0.45	neutral	4.31	deleterious	-5.51	deleterious	-5.4	high_impact	3.73	0.33	damaging	0.05	damaging	4.25	23.90	deleterious	0.18	0.45	0.76	disease	0.86	disease	0.78	disease	0.79	disease	6	1	deleterious	0.23	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.18	medium_impact	2.2	high_impact	0.64	0.8	29.52	7.17	0.59	P	1.00	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13499	13499	G	C	MI.21738	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1163	388	G	A	gGt/gCt	9.11	1	0	probably_damaging	1	neutral	0.55	neutral	4.26	deleterious	-5.3	deleterious	-5.4	medium_impact	3.1	0.37	damaging	0.08	damaging	3.19	22.70	deleterious	0.23	0.45	0.86	disease	0.75	disease	0.74	disease	0.79	disease	6	1	deleterious	0.28	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.28	medium_impact	1.63	medium_impact	0.70	0.85	29.52	7.17	0.66	P	0.79	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13499	13499	G	T	MI.21739	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1163	388	G	V	gGt/gTt	9.11	1	0	probably_damaging	1	neutral	0.51	neutral	4.23	deleterious	-5.19	deleterious	-8.09	high_impact	5.17	0.3	damaging	0.03	damaging	3.86	23.50	deleterious	0.12	0.4	0.87	disease	0.92	disease	0.81	disease	0.86	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.24	medium_impact	3.52	high_impact	0.57	0.8	29.52	7.17	0.71	P	0.98	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6048	6048	G	C	MI.2174	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	145	49	G	R	Ggt/Cgt	-3.11	0	0	possibly_damaging	0.83	deleterious	0.01	neutral	2.84	neutral	-0.52	deleterious	-3.92	high_impact	4.19	0.62	neutral	0.07	damaging	3.77	23.40	deleterious	0.31	0.55	0.51	disease	0.93	disease	0.57	disease	0.76	disease	5	0.99	deleterious	0.09	neutral	5	deleterious	0.82	deleterious	-1.4	low_impact	-0.92	medium_impact	2.77	high_impact	0.80	0.9	7.99	32.29	0.29	N	0.95	polymorphism	0.79	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13499	13499	G	A	MI.21740	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1163	388	G	D	gGt/gAt	9.11	1	0	probably_damaging	1	neutral	0.22	neutral	4.23	deleterious	-7.44	deleterious	-6.29	high_impact	5.17	0.29	damaging	0.02	damaging	3.89	23.50	deleterious	0.12	0.4	0.94	disease	0.92	disease	0.86	disease	0.86	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.07	medium_impact	3.52	high_impact	0.41	0.8	29.52	7.17	0.76	P	0.95	disease_causing	1	0.44	.	.	.	.	.	.	COSM488749	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13501	13501	T	C	MI.21741	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1165	389	F	L	Ttc/Ctc	-7.4	0	0	possibly_damaging	0.81	neutral	0.66	neutral	3.51	deleterious	-5.55	deleterious	-5.39	high_impact	4.79	0.37	damaging	0.54	neutral	4.21	23.90	deleterious	0.18	0.45	0.8	disease	0.85	disease	0.76	disease	0.8	disease	6	0.78	neutral	0.43	neutral	1	deleterious	0.87	deleterious	-1.34	low_impact	0.39	medium_impact	3.17	high_impact	0.57	0.8	15.75	7.18	0.74	P	0.92	disease_causing	0.58	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13501	13501	T	A	MI.21742	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1165	389	F	I	Ttc/Atc	-7.4	0	0	probably_damaging	0.94	neutral	0.4	neutral	3.4	deleterious	-6.24	deleterious	-5.39	high_impact	4.24	0.45	damaging	0.64	neutral	4.55	24.30	deleterious	0.12	0.4	0.96	disease	0.87	disease	0.79	disease	0.84	disease	7	0.94	neutral	0.23	neutral	2	deleterious	0.89	deleterious	-1.88	low_impact	0.14	medium_impact	2.67	high_impact	0.42	0.8	15.75	7.18	0.51	N	0.95	disease_causing	0.56	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13501	13501	T	G	MI.21743	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1165	389	F	V	Ttc/Gtc	-7.4	0	0	probably_damaging	0.91	neutral	0.5	neutral	3.4	deleterious	-5.82	deleterious	-6.29	high_impact	5.13	0.39	damaging	0.53	neutral	4.24	23.90	deleterious	0.11	0.4	0.96	disease	0.91	disease	0.8	disease	0.84	disease	7	0.9	neutral	0.3	neutral	2	deleterious	0.90	deleterious	-1.7	low_impact	0.23	medium_impact	3.48	high_impact	0.41	0.8	15.75	7.18	0.73	P	0.95	disease_causing	0.73	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13502	13502	T	G	MI.21744	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1166	389	F	C	tTc/tGc	5.67	1	0	probably_damaging	0.99	neutral	0.18	neutral	3.37	deleterious	-8.34	deleterious	-7.19	high_impact	4.79	0.45	damaging	0.53	neutral	4.20	23.90	deleterious	0.1	0.4	0.99	disease	0.89	disease	0.8	disease	0.89	disease	8	0.99	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-2.64	low_impact	-0.13	medium_impact	3.17	high_impact	0.32	0.8	15.75	7.18	0.65	P	0.99	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13502	13502	T	A	MI.21745	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1166	389	F	Y	tTc/tAc	5.67	1	0	benign	0.17	neutral	1	neutral	3.47	deleterious	-5.45	deleterious	-2.7	medium_impact	2.31	0.57	damaging	0.61	neutral	4.33	24.00	deleterious	0.16	0.45	0.87	disease	0.79	disease	0.74	disease	0.69	disease	4	0.17	neutral	0.92	deleterious	-3	neutral	0.87	deleterious	-0.09	medium_impact	1.89	high_impact	0.91	medium_impact	0.48	0.8	15.75	7.18	0.51	P	0.88	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13502	13502	T	C	MI.21746	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1166	389	F	S	tTc/tCc	5.67	1	0	probably_damaging	0.96	neutral	0.43	neutral	3.38	deleterious	-7	deleterious	-7.19	high_impact	4.33	0.49	damaging	0.68	neutral	4.33	24.00	deleterious	0.06	0.35	0.98	disease	0.89	disease	0.77	disease	0.88	disease	8	0.96	neutral	0.24	neutral	2	deleterious	0.91	deleterious	-2.06	low_impact	0.17	medium_impact	2.75	high_impact	0.41	0.8	15.75	7.18	0.6	P	0.97	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13503	13503	C	G	MI.21747	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1167	389	F	L	ttC/ttG	3.61	1	0	possibly_damaging	0.81	neutral	0.66	neutral	3.51	deleterious	-5.55	deleterious	-5.39	high_impact	4.79	0.37	damaging	0.54	neutral	4.46	24.20	deleterious	0.18	0.45	0.8	disease	0.85	disease	0.76	disease	0.8	disease	6	0.78	neutral	0.43	neutral	1	deleterious	0.87	deleterious	-1.34	low_impact	0.39	medium_impact	3.17	high_impact	0.57	0.8	15.75	7.18	0.78	P	0.92	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13503	13503	C	A	MI.21748	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1167	389	F	L	ttC/ttA	3.61	1	0	possibly_damaging	0.81	neutral	0.66	neutral	3.51	deleterious	-5.55	deleterious	-5.39	high_impact	4.79	0.37	damaging	0.54	neutral	4.69	24.60	deleterious	0.18	0.45	0.8	disease	0.85	disease	0.76	disease	0.8	disease	6	0.78	neutral	0.43	neutral	1	deleterious	0.87	deleterious	-1.34	low_impact	0.39	medium_impact	3.17	high_impact	0.57	0.8	15.75	7.18	0.78	P	0.92	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13504	13504	T	G	MI.21749	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1168	390	Y	D	Tac/Gac	-1.89	0	0	probably_damaging	0.96	neutral	0.22	neutral	4.47	deleterious	-4.22	deleterious	-8.99	high_impact	4.62	0.61	neutral	0.42	neutral	3.87	23.50	deleterious	0.19	0.45	0.93	disease	0.92	disease	0.8	disease	0.88	disease	8	0.97	neutral	0.13	neutral	2	deleterious	0.85	deleterious	-2.06	low_impact	-0.07	medium_impact	3.02	high_impact	0.40	0.8	17.74	7.12	0.6	P	0.96	disease_causing	0.96	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6048	6048	G	A	MI.2175	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	145	49	G	S	Ggt/Agt	-3.11	0	0	possibly_damaging	0.44	neutral	0.07	neutral	2.87	neutral	-1.57	deleterious	-2.84	medium_impact	2.3	0.67	neutral	0.08	damaging	4.02	23.60	deleterious	0.42	0.55	0.38	neutral	0.86	disease	0.4	neutral	0.53	disease	1	0.92	neutral	0.32	neutral	0	NA	0.55	deleterious	-0.66	medium_impact	-0.43	medium_impact	1.03	medium_impact	0.73	0.9	7.99	32.29	0.27	N	0.73	polymorphism	0.89	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13504	13504	T	C	MI.21750	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1168	390	Y	H	Tac/Cac	-1.89	0	0	benign	0.17	neutral	0.53	neutral	4.47	deleterious	-3.37	deleterious	-4.5	high_impact	3.58	0.72	neutral	0.47	neutral	1.67	14.26	neutral	0.42	0.5	0.89	disease	0.82	disease	0.79	disease	0.85	disease	7	0.37	neutral	0.68	deleterious	-2	neutral	0.36	neutral	-0.09	medium_impact	0.26	medium_impact	2.07	high_impact	0.56	0.8	17.74	7.12	0.33	N	0.98	disease_causing	0.77	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13504	13504	T	A	MI.21751	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1168	390	Y	N	Tac/Aac	-1.89	0	0	probably_damaging	0.92	neutral	0.3	neutral	4.48	deleterious	-3.69	deleterious	-8.09	high_impact	4.62	0.62	neutral	0.48	neutral	3.78	23.40	deleterious	0.28	0.45	0.87	disease	0.9	disease	0.73	disease	0.83	disease	7	0.93	neutral	0.19	neutral	2	deleterious	0.71	deleterious	-1.75	low_impact	0.03	medium_impact	3.02	high_impact	0.38	0.8	17.74	7.12	0.54	P	0.99	disease_causing	0.97	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13505	13505	A	G	MI.21752	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1169	390	Y	C	tAc/tGc	7.27	1	0	probably_damaging	0.98	neutral	0.18	neutral	4.49	deleterious	-3.39	deleterious	-8.09	high_impact	4.07	0.57	damaging	0.38	neutral	3.60	23.20	deleterious	0.28	0.45	0.75	disease	0.91	disease	0.75	disease	0.81	disease	6	0.99	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	-0.13	medium_impact	2.52	high_impact	0.30	0.8	17.74	7.12	0.56	P	1.00	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13505	13505	A	T	MI.21753	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1169	390	Y	F	tAc/tTc	7.27	1	0	possibly_damaging	0.85	neutral	0.74	neutral	4.58	neutral	0.96	deleterious	-3.6	neutral_impact	0.64	0.67	neutral	0.75	neutral	1.03	10.85	neutral	0.4	0.5	0.36	neutral	0.22	neutral	0.42	neutral	0.39	neutral	2	0.82	neutral	0.45	neutral	-3	neutral	0.61	deleterious	-1.46	low_impact	0.48	medium_impact	-0.62	medium_impact	0.60	0.8	17.74	7.12	0.53	P	0.80	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13505	13505	A	C	MI.21754	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1169	390	Y	S	tAc/tCc	7.27	1	0	probably_damaging	0.92	neutral	0.43	neutral	4.5	neutral	-2.36	deleterious	-8.09	high_impact	4.62	0.65	neutral	0.54	neutral	3.58	23.20	deleterious	0.27	0.45	0.69	disease	0.87	disease	0.71	disease	0.77	disease	5	0.92	neutral	0.26	neutral	2	deleterious	0.74	deleterious	-1.75	low_impact	0.17	medium_impact	3.02	high_impact	0.40	0.8	17.74	7.12	0.66	P	0.97	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13507	13507	T	A	MI.21755	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1171	391	S	T	Tcc/Acc	-1.21	0.01	0	probably_damaging	1	neutral	0.41	neutral	4.41	deleterious	-4.35	deleterious	-2.7	medium_impact	3.25	0.33	damaging	0.08	damaging	4.10	23.70	deleterious	0.18	0.45	0.92	disease	0.76	disease	0.58	disease	0.76	disease	5	1	deleterious	0.21	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.15	medium_impact	1.77	medium_impact	0.72	0.85	28.69	7.21	0.46	N	0.71	disease_causing	0.93	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13507	13507	T	C	MI.21756	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1171	391	S	P	Tcc/Ccc	-1.21	0.01	0	probably_damaging	1	neutral	0.2	neutral	4.41	deleterious	-6.04	deleterious	-4.5	high_impact	4.44	0.3	damaging	0.06	damaging	4.15	23.80	deleterious	0.2	0.45	0.86	disease	0.85	disease	0.78	disease	0.83	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.1	medium_impact	2.85	high_impact	0.61	0.8	28.69	7.21	0.61	P	0.98	disease_causing	0.99	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13507	13507	T	G	MI.21757	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1171	391	S	A	Tcc/Gcc	-1.21	0.01	0	probably_damaging	1	neutral	0.54	neutral	4.5	neutral	-2.44	deleterious	-2.7	medium_impact	3.17	0.38	damaging	0.14	damaging	3.82	23.40	deleterious	0.23	0.45	0.6	disease	0.65	disease	0.66	disease	0.67	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.27	medium_impact	1.69	medium_impact	0.75	0.85	28.69	7.21	0.49	N	0.49	disease_causing	0.81	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13508	13508	C	G	MI.21758	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1172	391	S	C	tCc/tGc	5.44	1	0	probably_damaging	1	neutral	0.18	neutral	4.41	deleterious	-7.88	deleterious	-4.5	high_impact	4.58	0.36	damaging	0.03	damaging	3.68	23.30	deleterious	0.19	0.45	0.98	disease	0.84	disease	0.68	disease	0.83	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.13	medium_impact	2.98	high_impact	0.52	0.8	28.69	7.21	0.58	P	0.99	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13508	13508	C	A	MI.21759	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1172	391	S	Y	tCc/tAc	5.44	1	0	probably_damaging	1	neutral	1	neutral	4.37	deleterious	-7.98	deleterious	-5.4	high_impact	4.79	0.34	damaging	0.05	damaging	4.19	23.80	deleterious	0.14	0.4	0.99	disease	0.89	disease	0.72	disease	0.84	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.90	deleterious	-3.6	low_impact	1.89	high_impact	3.17	high_impact	0.65	0.8	28.69	7.21	0.59	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6048	6048	G	T	MI.2176	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	145	49	G	C	Ggt/Tgt	-3.11	0	0	probably_damaging	0.95	deleterious	0.02	neutral	2.81	deleterious	-4.86	deleterious	-4.72	high_impact	3.99	0.61	neutral	0.07	damaging	4.01	23.60	deleterious	0.25	0.55	0.77	disease	0.94	disease	0.45	neutral	0.73	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.88	deleterious	-1.96	low_impact	-0.75	medium_impact	2.59	high_impact	0.50	0.9	7.99	32.29	0.3	N	0.98	polymorphism	0.66	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13508	13508	C	T	MI.21760	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1172	391	S	F	tCc/tTc	5.44	1	0	probably_damaging	1	neutral	0.88	neutral	4.38	deleterious	-7.61	deleterious	-5.4	high_impact	5.13	0.37	damaging	0.03	damaging	4.37	24.10	deleterious	0.17	0.45	0.99	disease	0.9	disease	0.72	disease	0.85	disease	7	1	deleterious	0.44	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.71	medium_impact	3.48	high_impact	0.36	0.8	28.69	7.21	0.6	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13510	13510	A	G	MI.21761	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1174	392	K	E	Aaa/Gaa	-7.4	0	0	probably_damaging	1	neutral	1	neutral	4.12	neutral	-2.11	deleterious	-3.6	high_impact	5.22	0.41	damaging	0.18	damaging	4.10	23.70	deleterious	0.32	0.5	0.52	disease	0.86	disease	0.73	disease	0.76	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.83	deleterious	-3.6	low_impact	1.89	high_impact	3.57	high_impact	0.60	0.8	27.69	7.26	0.65	P	0.84	disease_causing	0.75	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13510	13510	A	C	MI.21762	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1174	392	K	Q	Aaa/Caa	-7.4	0	0	probably_damaging	1	neutral	0.64	neutral	3.84	deleterious	-5.38	deleterious	-3.6	high_impact	4.67	0.42	damaging	0.16	damaging	3.56	23.10	deleterious	0.3	0.45	0.85	disease	0.82	disease	0.69	disease	0.77	disease	5	1	deleterious	0.32	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.37	medium_impact	3.06	high_impact	0.55	0.8	27.69	7.26	0.54	P	0.82	disease_causing	0.64	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13511	13511	A	T	MI.21763	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1175	392	K	M	aAa/aTa	8.42	1	0	probably_damaging	1	neutral	0.22	neutral	3.8	deleterious	-6.85	deleterious	-5.39	high_impact	4.33	0.41	damaging	0.18	damaging	4.08	23.70	deleterious	0.22	0.45	0.94	disease	0.84	disease	0.69	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.07	medium_impact	2.75	high_impact	0.38	0.8	27.69	7.26	0.72	P	0.40	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	A13511T	Leigh-like syndrome	-	+	Reported	1	.	P	P	damaging
chrM	13511	13511	A	C	MI.21764	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1175	392	K	T	aAa/aCa	8.42	1	0	probably_damaging	1	neutral	0.71	neutral	3.83	deleterious	-5.68	deleterious	-5.39	high_impact	5.22	0.38	damaging	0.17	damaging	3.70	23.30	deleterious	0.24	0.45	0.91	disease	0.86	disease	0.71	disease	0.8	disease	6	1	deleterious	0.36	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.45	medium_impact	3.57	high_impact	0.31	0.8	27.69	7.26	0.78	P	0.75	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13512	13512	A	T	MI.21765	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1176	392	K	N	aaA/aaT	8.42	1	0.01	probably_damaging	1	neutral	0.59	neutral	3.84	deleterious	-5.7	deleterious	-4.5	high_impact	5.22	0.31	damaging	0.15	damaging	3.98	23.60	deleterious	0.3	0.45	0.89	disease	0.83	disease	0.7	disease	0.78	disease	6	1	deleterious	0.3	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.32	medium_impact	3.57	high_impact	0.44	0.8	27.69	7.26	0.81	P	0.63	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13512	13512	A	C	MI.21766	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1176	392	K	N	aaA/aaC	8.42	1	0.01	probably_damaging	1	neutral	0.59	neutral	3.84	deleterious	-5.7	deleterious	-4.5	high_impact	5.22	0.31	damaging	0.15	damaging	3.90	23.50	deleterious	0.3	0.45	0.89	disease	0.83	disease	0.7	disease	0.78	disease	6	1	deleterious	0.3	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.32	medium_impact	3.57	high_impact	0.44	0.8	27.69	7.26	0.8	P	0.63	disease_causing	1	0.43	.	.	.	.	.	.	COSM6716791	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13513	13513	G	T	MI.21767	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1177	393	D	Y	Gac/Tac	4.52	1	0	probably_damaging	1	neutral	1	neutral	4.56	neutral	-2.85	deleterious	-8.09	high_impact	4.7	0.24	damaging	0.32	neutral	4.00	23.60	deleterious	0.25	0.45	0.85	disease	0.94	disease	0.79	disease	0.88	disease	8	1	deleterious	0.5	deleterious	2	deleterious	0.91	deleterious	-3.6	low_impact	1.89	high_impact	3.09	high_impact	0.33	0.8	28.19	7.12	0.82	P	0.99	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13513	13513	G	A	MI.21768	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1177	393	D	N	Gac/Aac	4.52	1	0	probably_damaging	1	neutral	0.32	neutral	4.5	deleterious	-3.73	deleterious	-4.5	high_impact	4.7	0.03	damaging	0.44	neutral	4.36	24.10	deleterious	0.45	0.55	0.82	disease	0.85	disease	0.76	disease	0.81	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.05	medium_impact	3.09	high_impact	0.80	0.85	28.19	7.12	0.97	P	0.98	disease_causing_automatic	1	0.41	rs267606897	Pathogenic	Leigh_syndrome|Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke|Mitochondrial_diseases|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency|not_provided	24741	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003|MedGen:C0751651,Orphanet:ORPHA68380|MedGen:C1838951|MedGen:CN517202	.	.	.	.	G13513A	Leigh Disease / MELAS / LHON-MELAS Overlap Syndrome	-	+	Cfrm	32	P	P	P	damaging
chrM	13513	13513	G	C	MI.21769	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1177	393	D	H	Gac/Cac	4.52	1	0	probably_damaging	1	neutral	0.53	neutral	4.51	deleterious	-4.65	deleterious	-6.29	medium_impact	3.42	0.25	damaging	0.31	neutral	3.69	23.30	deleterious	0.28	0.45	0.87	disease	0.87	disease	0.79	disease	0.85	disease	7	1	deleterious	0.27	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	0.26	medium_impact	1.92	medium_impact	0.44	0.8	28.19	7.12	0.89	P	0.99	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6049	6049	G	T	MI.2177	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	146	49	G	V	gGt/gTt	5.22	1	0	probably_damaging	0.9	deleterious	0.01	neutral	2.95	neutral	-2.61	deleterious	-4.64	medium_impact	2.75	0.61	neutral	0.08	damaging	3.62	23.20	deleterious	0.33	0.55	0.38	neutral	0.92	disease	0.46	neutral	0.73	disease	5	1	deleterious	0.06	neutral	5	deleterious	0.80	deleterious	-1.65	low_impact	-0.92	medium_impact	1.44	medium_impact	0.47	0.9	7.99	32.29	0.38	N	0.93	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13514	13514	A	G	MI.21770	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1178	393	D	G	gAc/gGc	9.11	1	0	probably_damaging	1	neutral	0.34	neutral	4.5	deleterious	-4.16	deleterious	-6.29	high_impact	4.24	0.21	damaging	0.44	neutral	4.01	23.60	deleterious	0.27	0.45	0.88	disease	0.89	disease	0.79	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.07	medium_impact	2.67	high_impact	0.28	0.8	28.19	7.12	0.95	P	0.98	disease_causing_automatic	1	0.28	rs587776440	Pathogenic	Leigh_syndrome	165638	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	papillary thyroid carcinoma	.	.	.	A13514G	Leigh Disease / MELAS	-	+	Cfrm	13	P	P	P	damaging
chrM	13514	13514	A	T	MI.21771	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1178	393	D	V	gAc/gTc	9.11	1	0	probably_damaging	1	neutral	0.51	neutral	4.59	neutral	-2.34	deleterious	-8.09	high_impact	4.7	0.16	damaging	0.36	neutral	3.76	23.30	deleterious	0.23	0.45	0.69	disease	0.93	disease	0.76	disease	0.81	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	0.24	medium_impact	3.09	high_impact	0.31	0.8	28.19	7.12	0.92	P	0.99	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13514	13514	A	C	MI.21772	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1178	393	D	A	gAc/gCc	9.11	1	0	probably_damaging	1	neutral	0.55	neutral	4.58	neutral	-2.56	deleterious	-7.19	high_impact	4.14	0.29	damaging	0.46	neutral	3.66	23.20	deleterious	0.25	0.45	0.62	disease	0.83	disease	0.76	disease	0.77	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.28	medium_impact	2.58	high_impact	0.41	0.8	28.19	7.12	0.92	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13515	13515	C	A	MI.21773	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1179	393	D	E	gaC/gaA	8.42	1	0	probably_damaging	1	neutral	0.29	neutral	4.52	neutral	-1.1	deleterious	-3.6	medium_impact	2.44	0.24	damaging	0.38	neutral	4.29	24.00	deleterious	0.37	0.5	0.6	disease	0.82	disease	0.68	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.02	medium_impact	1.03	medium_impact	0.62	0.8	28.19	7.12	0.93	P	0.91	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13515	13515	C	G	MI.21774	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1179	393	D	E	gaC/gaG	8.42	1	0	probably_damaging	1	neutral	0.29	neutral	4.52	neutral	-1.1	deleterious	-3.6	medium_impact	2.44	0.24	damaging	0.38	neutral	3.99	23.60	deleterious	0.37	0.5	0.6	disease	0.82	disease	0.68	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.02	medium_impact	1.03	medium_impact	0.62	0.8	28.19	7.12	0.93	P	0.91	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13516	13516	C	G	MI.21775	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1180	394	H	D	Cac/Gac	-0.06	0	0	benign	0	neutral	0.27	neutral	4.64	neutral	-0.23	neutral	-1.01	neutral_impact	0.14	0.68	neutral	0.5	neutral	1.95	15.91	deleterious	0.24	0.45	0.56	disease	0.68	disease	0.58	disease	0.67	disease	3	0.73	neutral	0.64	deleterious	-6	neutral	0.27	neutral	2.1	high_impact	-0.01	medium_impact	-1.08	low_impact	0.75	0.85	19.57	15.84	0.33	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13516	13516	C	A	MI.21776	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1180	394	H	N	Cac/Aac	-0.06	0	0	benign	0	neutral	0.36	neutral	4.7	neutral	0.28	neutral	-0.18	neutral_impact	-0.34	0.74	neutral	0.68	neutral	2.08	16.74	deleterious	0.43	0.55	0.58	disease	0.63	disease	0.38	neutral	0.46	neutral	1	0.64	neutral	0.68	deleterious	-6	neutral	0.24	neutral	2.1	high_impact	0.1	medium_impact	-1.51	low_impact	0.73	0.85	19.57	15.84	0.36	N	0.40	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13516	13516	C	T	MI.21777	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1180	394	H	Y	Cac/Tac	-0.06	0	0	benign	0	neutral	1	neutral	4.78	neutral	2.52	neutral	1.44	neutral_impact	-0.72	0.74	neutral	0.65	neutral	1.81	15.06	deleterious	0.43	0.55	0.35	neutral	0.58	disease	0.46	neutral	0.47	neutral	1	0	neutral	1	deleterious	-6	neutral	0.20	neutral	2.1	high_impact	1.89	high_impact	-1.86	low_impact	0.49	0.8	19.57	15.84	0.27	N	0.22	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13517	13517	A	C	MI.21778	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1181	394	H	P	cAc/cCc	0.17	0	0	benign	0	neutral	0.23	neutral	4.65	neutral	-0.35	neutral	0.11	neutral_impact	-1.04	0.89	neutral	0.93	neutral	0.15	4.14	deleterious	0.29	0.45	0.61	disease	0.82	disease	0.42	neutral	0.57	disease	1	0.77	neutral	0.62	deleterious	-6	neutral	0.32	neutral	2.1	high_impact	-0.06	medium_impact	-2.15	low_impact	0.58	0.8	19.57	15.84	0.32	N	0.40	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13517	13517	A	T	MI.21779	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1181	394	H	L	cAc/cTc	0.17	0	0	benign	0	neutral	0.68	neutral	4.87	neutral	3.91	neutral	5.42	neutral_impact	-3.25	0.86	neutral	0.97	neutral	-0.70	0.07	neutral	0.32	0.5	0.55	disease	0.41	neutral	0.2	neutral	0.63	disease	3	0.32	neutral	0.84	deleterious	-6	neutral	0.18	neutral	2.1	high_impact	0.41	medium_impact	-4.17	low_impact	0.36	0.8	19.57	15.84	0.3	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6049	6049	G	C	MI.2178	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	146	49	G	A	gGt/gCt	5.22	1	0	benign	0.19	deleterious	0.02	neutral	2.88	neutral	-1.56	deleterious	-3.05	medium_impact	3.29	0.69	neutral	0.1	damaging	3.00	22.20	deleterious	0.49	0.55	0.37	neutral	0.82	disease	0.37	neutral	0.54	disease	1	0.98	neutral	0.42	neutral	1	deleterious	0.49	deleterious	-0.16	medium_impact	-0.75	medium_impact	1.94	medium_impact	0.68	0.9	7.99	32.29	0.48	N	0.64	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13517	13517	A	G	MI.21780	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1181	394	H	R	cAc/cGc	0.17	0	0	benign	0	neutral	0.4	neutral	4.65	neutral	0.13	neutral	0.6	neutral_impact	-0.4	0.73	neutral	0.53	neutral	1.10	11.20	neutral	0.46	0.55	0.49	neutral	0.68	disease	0.5	neutral	0.48	neutral	0	0.6	neutral	0.7	deleterious	-6	neutral	0.27	neutral	2.1	high_impact	0.14	medium_impact	-1.57	low_impact	0.42	0.8	19.57	15.84	0.32	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13518	13518	C	G	MI.21781	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1182	394	H	Q	caC/caG	0.63	0	0	benign	0	neutral	0.35	neutral	4.65	neutral	0.41	neutral	0.65	neutral_impact	-0.4	0.76	neutral	0.75	neutral	1.65	14.13	neutral	0.55	0.6	0.62	disease	0.4	neutral	0.46	neutral	0.62	disease	2	0.65	neutral	0.68	deleterious	-6	neutral	0.23	neutral	2.1	high_impact	0.08	medium_impact	-1.57	low_impact	0.68	0.85	19.57	15.84	0.38	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13518	13518	C	A	MI.21782	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1182	394	H	Q	caC/caA	0.63	0	0	benign	0	neutral	0.35	neutral	4.65	neutral	0.41	neutral	0.65	neutral_impact	-0.4	0.76	neutral	0.75	neutral	2.05	16.55	deleterious	0.55	0.6	0.62	disease	0.4	neutral	0.46	neutral	0.62	disease	2	0.65	neutral	0.68	deleterious	-6	neutral	0.23	neutral	2.1	high_impact	0.08	medium_impact	-1.57	low_impact	0.68	0.85	19.57	15.84	0.39	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13519	13519	A	G	MI.21783	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1183	395	I	V	Atc/Gtc	-6.71	0	0	probably_damaging	1	neutral	0.53	neutral	4.59	neutral	-1.19	neutral	-0.9	medium_impact	3.13	0.38	damaging	0.1	damaging	3.01	22.30	deleterious	0.48	0.55	0.55	disease	0.56	disease	0.61	disease	0.64	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.26	medium_impact	1.66	medium_impact	0.68	0.85	29.19	7.16	0.46	N	0.74	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13519	13519	A	C	MI.21784	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1183	395	I	L	Atc/Ctc	-6.71	0	0	probably_damaging	1	neutral	0.87	neutral	4.57	neutral	-1.15	neutral	-1.8	medium_impact	2.47	0.4	damaging	0.1	damaging	3.74	23.30	deleterious	0.27	0.45	0.53	disease	0.75	disease	0.56	disease	0.65	disease	3	1	deleterious	0.44	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.69	medium_impact	1.05	medium_impact	0.69	0.85	29.19	7.16	0.41	N	0.86	polymorphism	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13519	13519	A	T	MI.21785	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1183	395	I	F	Atc/Ttc	-6.71	0	0	probably_damaging	1	neutral	0.91	neutral	4.31	deleterious	-3.24	deleterious	-3.6	medium_impact	3.23	0.39	damaging	0.05	damaging	3.75	23.30	deleterious	0.19	0.45	0.77	disease	0.86	disease	0.69	disease	0.73	disease	5	1	deleterious	0.46	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.79	medium_impact	1.75	medium_impact	0.83	0.85	29.19	7.16	0.37	N	0.96	disease_causing	0.66	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13520	13520	T	G	MI.21786	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1184	395	I	S	aTc/aGc	8.42	1	0	probably_damaging	1	neutral	0.73	neutral	4.35	deleterious	-4.71	deleterious	-5.4	high_impact	4.46	0.4	damaging	0.13	damaging	4.40	24.10	deleterious	0.18	0.45	0.88	disease	0.89	disease	0.68	disease	0.8	disease	6	1	deleterious	0.37	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	0.47	medium_impact	2.87	high_impact	0.56	0.8	29.19	7.16	0.69	P	0.96	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13520	13520	T	C	MI.21787	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1184	395	I	T	aTc/aCc	8.42	1	0	probably_damaging	1	neutral	0.55	neutral	4.34	deleterious	-3.74	deleterious	-4.5	high_impact	4.46	0.39	damaging	0.06	damaging	3.53	23.10	deleterious	0.26	0.45	0.76	disease	0.84	disease	0.68	disease	0.72	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.28	medium_impact	2.87	high_impact	0.62	0.8	29.19	7.16	0.63	P	0.96	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13520	13520	T	A	MI.21788	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1184	395	I	N	aTc/aAc	8.42	1	0	probably_damaging	1	neutral	0.5	neutral	4.28	deleterious	-6.15	deleterious	-6.29	high_impact	5.01	0.36	damaging	0.06	damaging	4.55	24.30	deleterious	0.15	0.45	0.94	disease	0.89	disease	0.69	disease	0.82	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.23	medium_impact	3.37	high_impact	0.57	0.8	29.19	7.16	0.66	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13521	13521	C	A	MI.21789	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1185	395	I	M	atC/atA	7.27	1	0	probably_damaging	1	neutral	0.32	neutral	4.31	deleterious	-3.39	deleterious	-2.7	medium_impact	2.6	0.44	damaging	0.09	damaging	3.97	23.60	deleterious	0.27	0.45	0.81	disease	0.75	disease	0.67	disease	0.72	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.05	medium_impact	1.17	medium_impact	0.77	0.85	29.19	7.16	0.55	P	0.76	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6049	6049	G	A	MI.2179	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	146	49	G	D	gGt/gAt	5.22	1	0	possibly_damaging	0.44	deleterious	0.01	neutral	2.82	neutral	-1.89	deleterious	-3.38	medium_impact	3.19	0.62	neutral	0.07	damaging	3.71	23.30	deleterious	0.31	0.55	0.55	disease	0.92	disease	0.53	disease	0.67	disease	3	0.99	deleterious	0.29	neutral	4	deleterious	0.64	deleterious	-0.66	medium_impact	-0.92	medium_impact	1.85	medium_impact	0.37	0.9	7.99	32.29	0.43	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13521	13521	C	G	MI.21790	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1185	395	I	M	atC/atG	7.27	1	0	probably_damaging	1	neutral	0.32	neutral	4.31	deleterious	-3.39	deleterious	-2.7	medium_impact	2.6	0.44	damaging	0.09	damaging	3.45	23.00	deleterious	0.27	0.45	0.81	disease	0.75	disease	0.67	disease	0.72	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.05	medium_impact	1.17	medium_impact	0.77	0.85	29.19	7.16	0.55	P	0.76	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13522	13522	A	T	MI.21791	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1186	396	I	F	Atc/Ttc	-3.73	0	0	probably_damaging	1	neutral	0.77	neutral	4.45	neutral	-1.26	deleterious	-3.6	medium_impact	2.4	0.54	damaging	0.07	damaging	3.88	23.50	deleterious	0.33	0.5	0.4	neutral	0.85	disease	0.68	disease	0.73	disease	5	1	deleterious	0.39	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.52	medium_impact	0.99	medium_impact	0.82	0.85	19.9	7.02	0.21	N	0.96	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13522	13522	A	G	MI.21792	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1186	396	I	V	Atc/Gtc	-3.73	0	0	probably_damaging	1	neutral	0.49	neutral	4.34	neutral	-2.77	neutral	-0.9	low_impact	1.94	0.53	damaging	0.21	damaging	3.17	22.70	deleterious	0.53	0.6	0.57	disease	0.5	neutral	0.56	disease	0.56	disease	1	1	deleterious	0.25	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.22	medium_impact	0.57	medium_impact	0.63	0.8	19.9	7.02	0.33	N	0.74	polymorphism	0.68	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13522	13522	A	C	MI.21793	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1186	396	I	L	Atc/Ctc	-3.73	0	0	probably_damaging	1	neutral	0.66	neutral	5.36	neutral	1.96	neutral	-1.8	neutral_impact	-0.11	0.49	damaging	0.13	damaging	3.90	23.50	deleterious	0.33	0.5	0.33	neutral	0.5	neutral	0.52	disease	0.42	neutral	2	1	deleterious	0.33	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.39	medium_impact	-1.3	low_impact	0.81	0.85	19.9	7.02	0.3	N	0.86	disease_causing	0.52	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13523	13523	T	C	MI.21794	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1187	396	I	T	aTc/aCc	4.29	0.99	0	probably_damaging	1	neutral	0.43	neutral	4.3	deleterious	-4.86	deleterious	-4.5	medium_impact	3.48	0.53	damaging	0.05	damaging	3.57	23.10	deleterious	0.32	0.5	0.79	disease	0.83	disease	0.67	disease	0.74	disease	5	1	deleterious	0.22	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.17	medium_impact	1.98	medium_impact	0.60	0.8	19.9	7.02	0.4	N	0.96	disease_causing	0.99	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13523	13523	T	A	MI.21795	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1187	396	I	N	aTc/aAc	4.29	0.99	0	probably_damaging	1	neutral	0.33	neutral	4.29	deleterious	-6.92	deleterious	-6.29	high_impact	4.29	0.52	damaging	0.05	damaging	4.61	24.40	deleterious	0.19	0.45	0.91	disease	0.88	disease	0.67	disease	0.81	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.06	medium_impact	2.72	high_impact	0.57	0.8	19.9	7.02	0.46	N	0.99	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13523	13523	T	G	MI.21796	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1187	396	I	S	aTc/aGc	4.29	0.99	0	probably_damaging	1	neutral	0.55	neutral	4.29	deleterious	-5.8	deleterious	-5.4	high_impact	3.6	0.51	damaging	0.11	damaging	4.43	24.20	deleterious	0.2	0.45	0.71	disease	0.89	disease	0.66	disease	0.74	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.28	medium_impact	2.09	high_impact	0.56	0.8	19.9	7.02	0.45	N	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13524	13524	C	G	MI.21797	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1188	396	I	M	atC/atG	5.67	1	0	probably_damaging	1	neutral	0.24	neutral	4.35	neutral	-2.53	deleterious	-2.7	medium_impact	2.66	0.56	damaging	0.13	damaging	3.49	23.10	deleterious	0.38	0.5	0.74	disease	0.7	disease	0.55	disease	0.63	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.04	medium_impact	1.23	medium_impact	0.83	0.85	19.9	7.02	0.47	N	0.76	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13524	13524	C	A	MI.21798	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1188	396	I	M	atC/atA	5.67	1	0	probably_damaging	1	neutral	0.24	neutral	4.35	neutral	-2.53	deleterious	-2.7	medium_impact	2.66	0.56	damaging	0.13	damaging	3.96	23.60	deleterious	0.38	0.5	0.74	disease	0.7	disease	0.55	disease	0.63	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.04	medium_impact	1.23	medium_impact	0.83	0.85	19.9	7.02	0.47	N	0.76	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13525	13525	G	C	MI.21799	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1189	397	E	Q	Gaa/Caa	-3.27	0	0	probably_damaging	1	neutral	0.3	neutral	4.54	neutral	-1.19	deleterious	-2.7	high_impact	3.76	0.3	damaging	0.06	damaging	3.44	23.00	deleterious	0.58	0.65	0.53	disease	0.79	disease	0.58	disease	0.67	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.03	medium_impact	2.23	high_impact	0.80	0.85	29.19	7.19	0.5	P	0.88	disease_causing	0.97	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8629	8629	A	G	MI.218	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	103	35	K	E	Aaa/Gaa	-14.22	0	0	benign	0.19	neutral	0.27	neutral	4.37	neutral	-0.51	neutral	-1.17	neutral_impact	0.55	0.91	neutral	0.73	neutral	0.75	9.15	deleterious	0.5	0.65	0.44	neutral	0.53	disease	0.52	disease	0.61	disease	2	0.68	neutral	0.54	deleterious	-6	neutral	0.41	neutral	-0.16	medium_impact	0.05	medium_impact	-0.63	medium_impact	0.68	0.9	20.35	18.29	0.36	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6051	6051	A	T	MI.2180	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	148	50	N	Y	Aac/Tac	-6.58	0	0	possibly_damaging	0.55	deleterious	0	neutral	2.82	neutral	-2.13	deleterious	-2.91	medium_impact	3.42	0.61	neutral	0.63	neutral	3.54	23.10	deleterious	0.48	0.55	0.64	disease	0.87	disease	0.65	disease	0.78	disease	6	1	deleterious	0.23	neutral	4	deleterious	0.54	deleterious	-0.84	medium_impact	-1.48	low_impact	2.06	high_impact	0.34	0.9	12.87	67.9	0.34	N	0.75	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13525	13525	G	A	MI.21800	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1189	397	E	K	Gaa/Aaa	-3.27	0	0	probably_damaging	1	neutral	0.32	neutral	4.53	neutral	-1.99	deleterious	-3.6	high_impact	3.68	0.28	damaging	0.04	damaging	4.62	24.50	deleterious	0.43	0.55	0.63	disease	0.89	disease	0.72	disease	0.76	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.05	medium_impact	2.16	high_impact	0.75	0.85	29.19	7.19	0.73	P	0.99	disease_causing	0.99	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13526	13526	A	G	MI.21801	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1190	397	E	G	gAa/gGa	7.04	1	0	probably_damaging	1	neutral	0.34	neutral	4.52	neutral	-2.56	deleterious	-6.29	medium_impact	3.19	0.3	damaging	0.08	damaging	4.40	24.10	deleterious	0.41	0.5	0.67	disease	0.82	disease	0.67	disease	0.69	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.07	medium_impact	1.71	medium_impact	0.40	0.8	29.19	7.19	0.69	P	0.52	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13526	13526	A	C	MI.21802	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1190	397	E	A	gAa/gCa	7.04	1	0	probably_damaging	1	neutral	0.53	neutral	4.59	neutral	-1.34	deleterious	-5.4	medium_impact	2.93	0.31	damaging	0.1	damaging	3.85	23.40	deleterious	0.38	0.5	0.59	disease	0.73	disease	0.66	disease	0.67	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.26	medium_impact	1.47	medium_impact	0.57	0.8	29.19	7.19	0.7	P	0.74	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13526	13526	A	T	MI.21803	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1190	397	E	V	gAa/gTa	7.04	1	0	probably_damaging	1	neutral	0.51	neutral	4.54	neutral	-2.38	deleterious	-6.29	high_impact	3.64	0.27	damaging	0.07	damaging	4.39	24.10	deleterious	0.33	0.5	0.68	disease	0.89	disease	0.69	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.24	medium_impact	2.12	high_impact	0.59	0.8	29.19	7.19	0.83	P	0.82	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13527	13527	A	C	MI.21804	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1191	397	E	D	gaA/gaC	8.42	1	0.01	probably_damaging	1	neutral	0.22	neutral	4.5	neutral	-2.38	deleterious	-2.7	medium_impact	3.4	0.27	damaging	0.06	damaging	3.80	23.40	deleterious	0.53	0.6	0.77	disease	0.77	disease	0.54	disease	0.68	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	-0.07	medium_impact	1.9	medium_impact	0.71	0.85	29.19	7.19	0.87	P	0.86	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13527	13527	A	T	MI.21805	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1191	397	E	D	gaA/gaT	8.42	1	0.01	probably_damaging	1	neutral	0.22	neutral	4.5	neutral	-2.38	deleterious	-2.7	medium_impact	3.4	0.27	damaging	0.06	damaging	3.90	23.50	deleterious	0.53	0.6	0.77	disease	0.77	disease	0.54	disease	0.68	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	-0.07	medium_impact	1.9	medium_impact	0.71	0.85	29.19	7.19	0.88	P	0.86	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13528	13528	A	C	MI.21806	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1192	398	T	P	Acc/Ccc	0.63	0.09	0	probably_damaging	0.97	neutral	0.25	neutral	3.67	deleterious	-3.23	deleterious	-2.96	medium_impact	2.72	0.65	neutral	0.36	neutral	3.53	23.10	deleterious	0.21	0.45	NA	NA	0.82	disease	0.68	disease	0.78	disease	6	0.98	neutral	0.14	neutral	1	deleterious	0.88	deleterious	-2.18	low_impact	-0.03	medium_impact	1.28	medium_impact	0.68	0.85	3.65	10.2	0.36	N	0.59	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13528	13528	A	T	MI.21807	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1192	398	T	S	Acc/Tcc	0.63	0.09	0	benign	0.26	neutral	0.55	neutral	3.81	neutral	0.21	neutral	-0.17	neutral_impact	0.08	0.85	neutral	0.99	neutral	2.00	16.20	deleterious	0.57	0.65	NA	NA	0.29	neutral	0.25	neutral	0.18	neutral	6	0.34	neutral	0.65	deleterious	-6	neutral	0.76	deleterious	-0.32	medium_impact	0.28	medium_impact	-1.13	low_impact	0.77	0.85	3.65	10.2	0.36	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13528	13528	A	G	MI.21808	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1192	398	T	A	Acc/Gcc	0.63	0.09	0	benign	0.12	neutral	0.66	neutral	3.95	neutral	1.43	neutral	-0.85	neutral_impact	-0.86	0.84	neutral	0.99	neutral	0.76	9.24	deleterious	0.62	0.65	NA	NA	0.05	neutral	0.21	neutral	0.18	neutral	6	0.23	neutral	0.77	deleterious	-6	neutral	0.69	deleterious	0.08	medium_impact	0.39	medium_impact	-1.99	low_impact	0.56	0.8	3.65	10.2	0.45	N	0.00	polymorphism	1	0.01	rs55882959	.	.	.	.	.	.	.	.	A13528G	LHON-like, LHON, MELAS	+	-	Reported	4	N	P	N,P	neutral
chrM	13529	13529	C	A	MI.21809	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1193	398	T	N	aCc/aAc	-3.73	0	0	possibly_damaging	0.88	neutral	0.4	neutral	3.71	neutral	-1.61	neutral	-2.17	low_impact	1	0.75	neutral	0.76	neutral	3.85	23.40	deleterious	0.64	0.7	NA	NA	0.66	disease	0.43	neutral	0.5	neutral	0	0.88	neutral	0.26	neutral	-3	neutral	0.80	deleterious	-1.57	low_impact	0.14	medium_impact	-0.29	medium_impact	0.77	0.85	3.65	10.2	0.3	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6051	6051	A	C	MI.2181	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	148	50	N	H	Aac/Cac	-6.58	0	0	possibly_damaging	0.62	deleterious	0	neutral	2.82	neutral	-1.28	neutral	-1.6	medium_impact	3.42	0.63	neutral	0.53	neutral	2.92	21.90	deleterious	0.74	0.75	0.53	disease	0.78	disease	0.66	disease	0.75	disease	5	1	deleterious	0.19	neutral	4	deleterious	0.50	deleterious	-0.96	medium_impact	-1.48	low_impact	2.06	high_impact	0.41	0.9	12.87	67.9	0.35	N	0.39	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13529	13529	C	G	MI.21810	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1193	398	T	S	aCc/aGc	-3.73	0	0	benign	0.26	neutral	0.55	neutral	3.81	neutral	0.21	neutral	-0.17	neutral_impact	0.08	0.85	neutral	0.99	neutral	2.29	18.12	deleterious	0.57	0.65	NA	NA	0.29	neutral	0.25	neutral	0.18	neutral	6	0.34	neutral	0.65	deleterious	-6	neutral	0.76	deleterious	-0.32	medium_impact	0.28	medium_impact	-1.13	low_impact	0.77	0.85	3.65	10.2	0.3	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13529	13529	C	T	MI.21811	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1193	398	T	I	aCc/aTc	-3.73	0	0	probably_damaging	0.94	neutral	0.44	neutral	3.7	neutral	-1.85	deleterious	-3.28	low_impact	1.07	0.77	neutral	0.62	neutral	3.98	23.60	deleterious	0.54	0.6	NA	NA	0.66	disease	0.53	disease	0.53	disease	1	0.94	neutral	0.25	neutral	-2	neutral	0.82	deleterious	-1.88	low_impact	0.18	medium_impact	-0.23	medium_impact	0.58	0.8	3.65	10.2	0.24	N	0.52	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13531	13531	G	T	MI.21812	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1195	399	A	S	Gca/Tca	-8.08	0	0	possibly_damaging	0.81	neutral	0.43	neutral	3.41	deleterious	-3.22	neutral	-2.04	neutral_impact	0.52	0.84	neutral	0.66	neutral	3.81	23.40	deleterious	0.55	0.6	NA	NA	0.54	disease	0.48	neutral	0.5	neutral	0	0.81	neutral	0.31	neutral	-3	neutral	0.83	deleterious	-1.34	low_impact	0.17	medium_impact	-0.73	medium_impact	0.89	0.9	25.7	16.15	0.26	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13531	13531	G	A	MI.21813	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1195	399	A	T	Gca/Aca	-8.08	0	0	benign	0.18	neutral	0.4	neutral	3.35	deleterious	-3.41	deleterious	-2.5	neutral_impact	0.78	0.86	neutral	0.73	neutral	3.24	22.80	deleterious	0.59	0.65	NA	NA	0.54	disease	0.53	disease	0.49	neutral	0	0.52	neutral	0.61	deleterious	-6	neutral	0.76	deleterious	-0.12	medium_impact	0.14	medium_impact	-0.49	medium_impact	0.70	0.85	25.7	16.15	0.29	N	0.30	polymorphism	1	0.06	.	.	.	.	.	.	COSM1155542	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13531	13531	G	C	MI.21814	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1195	399	A	P	Gca/Cca	-8.08	0	0	probably_damaging	0.98	neutral	0.2	neutral	3.29	deleterious	-6.21	deleterious	-3.6	medium_impact	2.89	0.6	neutral	0.38	neutral	3.98	23.60	deleterious	0.17	0.45	NA	NA	0.85	disease	0.67	disease	0.79	disease	6	0.99	deleterious	0.11	neutral	1	deleterious	0.90	deleterious	-2.35	low_impact	-0.1	medium_impact	1.44	medium_impact	0.79	0.85	25.7	16.15	0.3	N	0.89	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13532	13532	C	G	MI.21815	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1196	399	A	G	gCa/gGa	-0.52	0	0	possibly_damaging	0.86	neutral	0.33	neutral	3.35	deleterious	-3.03	deleterious	-3.2	low_impact	1.37	0.78	neutral	0.63	neutral	4.07	23.70	deleterious	0.32	0.5	NA	NA	0.58	disease	0.49	neutral	0.49	neutral	0	0.88	neutral	0.24	neutral	-3	neutral	0.81	deleterious	-1.5	low_impact	0.06	medium_impact	0.05	medium_impact	0.82	0.85	25.7	16.15	0.28	N	0.60	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13532	13532	C	A	MI.21816	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1196	399	A	E	gCa/gAa	-0.52	0	0	probably_damaging	0.96	neutral	0.28	neutral	3.29	deleterious	-5.85	deleterious	-3.6	medium_impact	2.89	0.72	neutral	0.51	neutral	4.57	24.40	deleterious	0.17	0.45	NA	NA	0.8	disease	0.67	disease	0.76	disease	5	0.97	neutral	0.16	neutral	1	deleterious	0.87	deleterious	-2.06	low_impact	0.01	medium_impact	1.44	medium_impact	0.72	0.85	25.7	16.15	0.34	N	0.89	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13532	13532	C	T	MI.21817	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1196	399	A	V	gCa/gTa	-0.52	0	0	possibly_damaging	0.61	neutral	0.5	neutral	3.43	neutral	-2.6	neutral	-2.01	low_impact	0.84	0.84	neutral	0.79	neutral	3.38	22.90	deleterious	0.52	0.6	NA	NA	0.55	disease	0.43	neutral	0.49	neutral	0	0.59	neutral	0.45	neutral	-3	neutral	0.78	deleterious	-0.93	medium_impact	0.23	medium_impact	-0.44	medium_impact	0.72	0.85	25.7	16.15	0.25	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	COSM3307733	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13534	13534	A	T	MI.21818	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1198	400	N	Y	Aac/Tac	-1.89	0	0	probably_damaging	0.94	neutral	1	neutral	3.79	neutral	0.51	deleterious	-6.21	low_impact	1.79	0.72	neutral	0.55	neutral	3.73	23.30	deleterious	0.53	0.6	NA	NA	0.79	disease	0.71	disease	0.57	disease	1	0.94	neutral	0.53	deleterious	-2	neutral	0.76	deleterious	-1.88	low_impact	1.89	high_impact	0.43	medium_impact	0.48	0.8	6.97	13.86	0.2	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13534	13534	A	C	MI.21819	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1198	400	N	H	Aac/Cac	-1.89	0	0	probably_damaging	0.94	neutral	0.53	neutral	3.74	neutral	-0.81	deleterious	-3.96	high_impact	3.6	0.71	neutral	0.41	neutral	3.03	22.30	deleterious	0.56	0.6	NA	NA	0.74	disease	0.77	disease	0.72	disease	4	0.94	neutral	0.3	neutral	2	deleterious	0.76	deleterious	-1.88	low_impact	0.26	medium_impact	2.09	high_impact	0.54	0.8	6.97	13.86	0.34	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6051	6051	A	G	MI.2182	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	148	50	N	D	Aac/Gac	-6.58	0	0	benign	0	neutral	1	neutral	2.99	neutral	2.12	neutral	1.72	neutral_impact	0.02	0.73	neutral	0.93	neutral	-0.70	0.07	neutral	0.81	0.85	0.19	neutral	0.12	neutral	0.29	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	1.86	high_impact	-1.08	low_impact	0.54	0.9	12.87	67.9	0.4	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13534	13534	A	G	MI.21820	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1198	400	N	D	Aac/Gac	-1.89	0	0	benign	0.42	neutral	0.24	neutral	3.74	neutral	-0.65	deleterious	-3.79	medium_impact	3.05	0.73	neutral	0.42	neutral	2.15	17.18	deleterious	0.62	0.65	NA	NA	0.77	disease	0.65	disease	0.68	disease	4	0.72	neutral	0.41	neutral	-3	neutral	0.50	deleterious	-0.61	medium_impact	-0.04	medium_impact	1.58	medium_impact	0.68	0.85	6.97	13.86	0.34	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13535	13535	A	G	MI.21821	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1199	400	N	S	aAc/aGc	5.44	0.69	0	benign	0.04	neutral	0.46	neutral	3.85	neutral	0.66	deleterious	-3.29	low_impact	0.9	0.78	neutral	0.81	neutral	1.12	11.32	neutral	0.65	0.7	NA	NA	0.71	disease	0.59	disease	0.54	disease	1	0.51	neutral	0.71	deleterious	-6	neutral	0.25	neutral	0.57	medium_impact	0.19	medium_impact	-0.38	medium_impact	0.48	0.8	6.97	13.86	0.34	N	0.81	polymorphism	0.86	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13535	13535	A	T	MI.21822	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1199	400	N	I	aAc/aTc	5.44	0.69	0	possibly_damaging	0.84	neutral	0.43	neutral	3.79	neutral	0.31	deleterious	-6.82	medium_impact	2.54	0.74	neutral	0.6	neutral	3.60	23.20	deleterious	0.52	0.6	NA	NA	0.89	disease	0.66	disease	0.69	disease	4	0.84	neutral	0.3	neutral	0	NA	0.73	deleterious	-1.43	low_impact	0.17	medium_impact	1.12	medium_impact	0.48	0.8	6.97	13.86	0.4	N	0.98	disease_causing	0.61	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13535	13535	A	C	MI.21823	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1199	400	N	T	aAc/aCc	5.44	0.69	0	benign	0.42	neutral	0.45	neutral	3.83	neutral	0.35	deleterious	-3.88	low_impact	1.64	0.81	neutral	0.93	neutral	0.55	7.79	deleterious	0.55	0.6	NA	NA	0.72	disease	0.53	disease	0.5	neutral	0	0.5	neutral	0.52	deleterious	-6	neutral	0.40	neutral	-0.61	medium_impact	0.18	medium_impact	0.3	medium_impact	0.52	0.8	6.97	13.86	0.33	N	0.60	polymorphism	0.66	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13536	13536	C	G	MI.21824	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1200	400	N	K	aaC/aaG	1.08	0.28	0	possibly_damaging	0.56	neutral	0.34	neutral	3.75	neutral	-0.49	deleterious	-4.51	high_impact	3.6	0.71	neutral	0.4	neutral	2.29	18.09	deleterious	0.64	0.7	NA	NA	0.82	disease	0.76	disease	0.77	disease	5	0.66	neutral	0.39	neutral	1	deleterious	0.58	deleterious	-0.85	medium_impact	0.07	medium_impact	2.09	high_impact	0.52	0.8	6.97	13.86	0.4	N	0.95	polymorphism	0.71	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13536	13536	C	A	MI.21825	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1200	400	N	K	aaC/aaA	1.08	0.28	0	possibly_damaging	0.56	neutral	0.34	neutral	3.75	neutral	-0.49	deleterious	-4.51	high_impact	3.6	0.71	neutral	0.4	neutral	2.79	21.30	deleterious	0.64	0.7	NA	NA	0.82	disease	0.76	disease	0.77	disease	5	0.66	neutral	0.39	neutral	1	deleterious	0.58	deleterious	-0.85	medium_impact	0.07	medium_impact	2.09	high_impact	0.52	0.8	6.97	13.86	0.4	N	0.95	polymorphism	0.71	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13537	13537	A	C	MI.21826	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1201	401	M	L	Ata/Cta	-1.67	0	0	benign	0.04	neutral	0.75	neutral	3.88	neutral	1.34	neutral	-0.38	low_impact	0.88	0.84	neutral	0.8	neutral	3.03	22.30	deleterious	0.57	0.65	NA	NA	0.51	disease	0.58	disease	0.52	disease	0	0.19	neutral	0.86	deleterious	-6	neutral	0.51	deleterious	0.57	medium_impact	0.5	medium_impact	-0.4	medium_impact	0.59	0.8	9.45	13.07	0.26	N	0.48	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13537	13537	A	G	MI.21827	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1201	401	M	V	Ata/Gta	-1.67	0	0	benign	0.06	neutral	0.52	neutral	3.79	neutral	0.54	neutral	0.12	low_impact	1.83	0.82	neutral	0.87	neutral	2.54	19.72	deleterious	0.61	0.65	NA	NA	0.47	neutral	0.61	disease	0.41	neutral	2	0.43	neutral	0.73	deleterious	-6	neutral	0.55	deleterious	0.39	medium_impact	0.25	medium_impact	0.47	medium_impact	0.62	0.8	9.45	13.07	0.33	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13537	13537	A	T	MI.21828	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1201	401	M	L	Ata/Tta	-1.67	0	0	benign	0.04	neutral	0.75	neutral	3.88	neutral	1.34	neutral	-0.38	low_impact	0.88	0.84	neutral	0.8	neutral	3.10	22.50	deleterious	0.57	0.65	NA	NA	0.51	disease	0.58	disease	0.52	disease	0	0.19	neutral	0.86	deleterious	-6	neutral	0.51	deleterious	0.57	medium_impact	0.5	medium_impact	-0.4	medium_impact	0.59	0.8	9.45	13.07	0.27	N	0.48	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13538	13538	T	A	MI.21829	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1202	401	M	K	aTa/aAa	2.46	0.4	0	benign	0.16	neutral	0.28	neutral	3.78	neutral	0.17	neutral	-0.74	medium_impact	2.56	0.71	neutral	0.53	neutral	4.11	23.70	deleterious	0.31	0.45	NA	NA	0.71	disease	0.63	disease	0.71	disease	4	0.67	neutral	0.56	deleterious	-3	neutral	0.76	deleterious	-0.06	medium_impact	0.01	medium_impact	1.14	medium_impact	0.55	0.8	9.45	13.07	0.35	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6052	6052	A	T	MI.2183	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	149	50	N	I	aAc/aTc	5.22	1	0	benign	0.35	deleterious	0	neutral	2.8	neutral	-1.75	deleterious	-3.03	high_impact	4.22	0.62	neutral	0.62	neutral	3.55	23.10	deleterious	0.38	0.55	0.36	neutral	0.87	disease	0.58	disease	0.78	disease	6	1	deleterious	0.33	neutral	2	deleterious	0.34	neutral	-0.5	medium_impact	-1.48	low_impact	2.8	high_impact	0.20	0.9	12.87	67.9	0.5	P	0.70	disease_causing	0.77	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13538	13538	T	C	MI.21830	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1202	401	M	T	aTa/aCa	2.46	0.4	0	benign	0	neutral	0.44	neutral	3.8	neutral	0.22	neutral	3.42	neutral_impact	-0.75	0.85	neutral	0.94	neutral	0.36	6.24	deleterious	0.54	0.6	NA	NA	0.11	neutral	0.2	neutral	0.22	neutral	6	0.56	neutral	0.72	deleterious	-6	neutral	0.61	deleterious	2.1	high_impact	0.18	medium_impact	-1.89	low_impact	0.30	0.8	9.45	13.07	0.37	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13539	13539	A	C	MI.21831	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1203	401	M	I	atA/atC	2.23	0.41	0.01	benign	0.12	neutral	0.54	neutral	3.78	neutral	0.43	neutral	-0.53	low_impact	1.54	0.74	neutral	0.81	neutral	3.42	23.00	deleterious	0.62	0.65	NA	NA	0.53	disease	0.46	neutral	0.49	neutral	0	0.37	neutral	0.71	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.27	medium_impact	0.2	medium_impact	0.57	0.8	9.45	13.07	0.32	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13539	13539	A	T	MI.21832	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1203	401	M	I	atA/atT	2.23	0.41	0.01	benign	0.12	neutral	0.54	neutral	3.78	neutral	0.43	neutral	-0.53	low_impact	1.54	0.74	neutral	0.81	neutral	3.52	23.10	deleterious	0.62	0.65	NA	NA	0.53	disease	0.46	neutral	0.49	neutral	0	0.37	neutral	0.71	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.27	medium_impact	0.2	medium_impact	0.57	0.8	9.45	13.07	0.32	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13540	13540	T	A	MI.21833	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1204	402	S	T	Tca/Aca	-3.96	0	0	probably_damaging	1	neutral	0.4	neutral	3.57	neutral	-1.93	deleterious	-2.6	medium_impact	3.04	0.64	neutral	0.14	damaging	3.82	23.40	deleterious	0.39	0.5	NA	NA	0.69	disease	0.7	disease	0.69	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.14	medium_impact	1.57	medium_impact	0.86	0.9	10.45	13	0.26	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13540	13540	T	C	MI.21834	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1204	402	S	P	Tca/Cca	-3.96	0	0	probably_damaging	1	neutral	0.2	neutral	3.52	deleterious	-3.21	deleterious	-4.4	high_impact	3.52	0.66	neutral	0.11	damaging	4.09	23.70	deleterious	0.19	0.45	NA	NA	0.84	disease	0.81	disease	0.8	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.1	medium_impact	2.01	high_impact	0.64	0.8	10.45	13	0.38	N	0.92	polymorphism	0.98	0.09	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13540	13540	T	G	MI.21835	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1204	402	S	A	Tca/Gca	-3.96	0	0	probably_damaging	0.99	neutral	0.51	neutral	3.63	neutral	-0.62	deleterious	-2.56	medium_impact	3.12	0.63	neutral	0.13	damaging	3.81	23.40	deleterious	0.5	0.6	NA	NA	0.55	disease	0.7	disease	0.67	disease	3	0.99	deleterious	0.26	neutral	1	deleterious	0.73	deleterious	-2.64	low_impact	0.24	medium_impact	1.65	medium_impact	0.76	0.85	10.45	13	0.26	N	0.39	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13541	13541	C	G	MI.21836	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1205	402	S	W	tCa/tGa	7.27	1	0	probably_damaging	1	neutral	0.19	neutral	3.5	deleterious	-4.9	deleterious	-6.09	high_impact	4.22	0.67	neutral	0.1	damaging	4.42	24.20	deleterious	0.22	0.45	NA	NA	0.89	disease	0.78	disease	0.8	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.12	medium_impact	2.65	high_impact	0.49	0.8	10.45	13	0.54	P	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13541	13541	C	T	MI.21837	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1205	402	S	L	tCa/tTa	7.27	1	0	probably_damaging	1	neutral	0.66	neutral	3.56	neutral	-2.77	deleterious	-5.2	high_impact	3.59	0.61	neutral	0.11	damaging	4.72	24.60	deleterious	0.33	0.5	NA	NA	0.87	disease	0.71	disease	0.76	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.39	medium_impact	2.08	high_impact	0.84	0.9	10.45	13	0.51	N	0.93	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13543	13543	T	G	MI.21838	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1207	403	Y	D	Tac/Gac	-7.17	0	0	possibly_damaging	0.84	neutral	0.22	neutral	3.68	neutral	-1.35	deleterious	-6.47	medium_impact	2.15	0.76	neutral	0.39	neutral	3.78	23.40	deleterious	0.44	0.55	0.55	disease	0.87	disease	0.78	disease	0.81	disease	6	0.9	neutral	0.19	neutral	0	NA	0.68	deleterious	-1.43	low_impact	-0.07	medium_impact	0.76	medium_impact	0.33	0.8	5.64	10.11	0.33	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13543	13543	T	A	MI.21839	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1207	403	Y	N	Tac/Aac	-7.17	0	0	possibly_damaging	0.67	neutral	0.35	neutral	3.72	neutral	-0.98	deleterious	-4.93	low_impact	0.85	0.82	neutral	0.97	neutral	1.20	11.76	neutral	0.49	0.55	0.44	neutral	0.67	disease	0.4	neutral	0.48	neutral	0	0.72	neutral	0.34	neutral	-3	neutral	0.46	deleterious	-1.04	low_impact	0.08	medium_impact	-0.43	medium_impact	0.26	0.8	5.64	10.11	0.32	N	0.47	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6052	6052	A	G	MI.2184	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	149	50	N	S	aAc/aGc	5.22	1	0	benign	0	neutral	0.2	neutral	2.94	neutral	0.2	neutral	-0.98	low_impact	1.12	0.69	neutral	0.85	neutral	-0.06	2.05	deleterious	0.8	0.8	0.24	neutral	0.67	disease	0.38	neutral	0.48	neutral	0	0.8	neutral	0.6	deleterious	-6	neutral	0.19	neutral	2.07	high_impact	-0.14	medium_impact	-0.07	medium_impact	0.19	0.9	12.87	67.9	0.61	P	0.14	polymorphism	0.74	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13543	13543	T	C	MI.21840	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1207	403	Y	H	Tac/Cac	-7.17	0	0	benign	0.03	neutral	0.53	neutral	3.71	neutral	-0.27	neutral	-2.37	neutral_impact	0.79	0.8	neutral	0.88	neutral	0.24	5.10	deleterious	0.7	0.75	0.63	disease	0.31	neutral	0.35	neutral	0.61	disease	2	0.43	neutral	0.75	deleterious	-6	neutral	0.22	neutral	0.69	medium_impact	0.26	medium_impact	-0.48	medium_impact	0.43	0.8	5.64	10.11	0.22	N	0.70	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13544	13544	A	G	MI.21841	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1208	403	Y	C	tAc/tGc	-0.52	0	0	probably_damaging	0.94	neutral	0.18	neutral	3.62	deleterious	-5.05	deleterious	-6.54	medium_impact	3.42	0.85	neutral	0.48	neutral	3.46	23.00	deleterious	0.4	0.5	0.65	disease	0.87	disease	0.61	disease	0.74	disease	5	0.97	neutral	0.12	neutral	1	deleterious	0.78	deleterious	-1.88	low_impact	-0.13	medium_impact	1.92	medium_impact	0.09	0.8	5.64	10.11	0.35	N	0.84	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13544	13544	A	C	MI.21842	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1208	403	Y	S	tAc/tCc	-0.52	0	0	possibly_damaging	0.74	neutral	0.46	neutral	3.72	neutral	-0.34	deleterious	-5.76	medium_impact	2.06	0.8	neutral	0.75	neutral	2.12	17.00	deleterious	0.38	0.5	0.39	neutral	0.79	disease	0.49	neutral	0.54	disease	1	0.73	neutral	0.36	neutral	0	NA	0.53	deleterious	-1.18	low_impact	0.19	medium_impact	0.68	medium_impact	0.28	0.8	5.64	10.11	0.26	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13544	13544	A	T	MI.21843	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1208	403	Y	F	tAc/tTc	-0.52	0	0	possibly_damaging	0.59	neutral	0.7	neutral	3.7	neutral	-0.51	deleterious	-3.06	medium_impact	2.1	0.79	neutral	0.66	neutral	1.71	14.47	neutral	0.51	0.6	0.73	disease	0.77	disease	0.38	neutral	0.58	disease	2	0.5	neutral	0.56	deleterious	0	NA	0.62	deleterious	-0.9	medium_impact	0.44	medium_impact	0.72	medium_impact	0.33	0.8	5.64	10.11	0.19	N	0.57	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13546	13546	A	G	MI.21844	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1210	404	T	A	Aca/Gca	-2.81	0	0	benign	0.22	neutral	0.6	neutral	3.76	neutral	-0.24	deleterious	-3.44	low_impact	1.64	0.79	neutral	0.78	neutral	-0.07	2.00	neutral	0.62	0.65	0.31	neutral	0.43	neutral	0.61	disease	0.5	disease	0	0.29	neutral	0.69	deleterious	-6	neutral	0.24	neutral	-0.22	medium_impact	0.33	medium_impact	0.3	medium_impact	0.43	0.8	5.97	9.01	0.29	N	0.67	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13546	13546	A	T	MI.21845	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1210	404	T	S	Aca/Tca	-2.81	0	0	possibly_damaging	0.46	neutral	0.44	neutral	3.82	neutral	-0.56	deleterious	-2.97	low_impact	1.17	0.83	neutral	0.6	neutral	0.42	6.80	deleterious	0.47	0.55	0.44	neutral	0.48	neutral	0.59	disease	0.5	neutral	0	0.53	neutral	0.49	deleterious	-3	neutral	0.35	neutral	-0.68	medium_impact	0.18	medium_impact	-0.13	medium_impact	0.56	0.8	5.97	9.01	0.27	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13546	13546	A	C	MI.21846	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1210	404	T	P	Aca/Cca	-2.81	0	0	possibly_damaging	0.87	neutral	0.19	neutral	3.71	neutral	-1.18	deleterious	-4.55	medium_impact	2.25	0.67	neutral	0.41	neutral	2.18	17.41	deleterious	0.21	0.45	0.78	disease	0.87	disease	0.72	disease	0.78	disease	6	0.92	neutral	0.16	neutral	0	NA	0.74	deleterious	-1.53	low_impact	-0.12	medium_impact	0.85	medium_impact	0.55	0.8	5.97	9.01	0.28	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13547	13547	C	A	MI.21847	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1211	404	T	K	aCa/aAa	-0.52	0	0	possibly_damaging	0.52	neutral	0.28	neutral	3.72	neutral	-1.01	deleterious	-4.5	medium_impact	2.65	0.72	neutral	0.43	neutral	1.70	14.43	neutral	0.32	0.5	0.85	disease	0.79	disease	0.72	disease	0.8	disease	6	0.7	neutral	0.38	neutral	0	NA	0.55	deleterious	-0.78	medium_impact	0.01	medium_impact	1.22	medium_impact	0.62	0.8	5.97	9.01	0.28	N	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13547	13547	C	T	MI.21848	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1211	404	T	M	aCa/aTa	-0.52	0	0	benign	0.14	neutral	0.23	neutral	3.71	neutral	-2.57	deleterious	-3.72	low_impact	1	0.77	neutral	0.74	neutral	0.99	10.62	neutral	0.54	0.6	0.63	disease	0.57	disease	0.45	neutral	0.53	disease	1	0.73	neutral	0.55	deleterious	-6	neutral	0.19	neutral	0	medium_impact	-0.06	medium_impact	-0.29	medium_impact	0.64	0.8	5.97	9.01	0.34	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13549	13549	A	C	MI.21849	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1213	405	N	H	Aac/Cac	-1.67	0	0	probably_damaging	1	neutral	0.53	neutral	3.56	neutral	-1.8	deleterious	-4.49	high_impact	3.7	0.62	neutral	0.11	damaging	3.18	22.70	deleterious	0.53	0.6	0.82	disease	0.8	disease	0.82	disease	0.83	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.26	medium_impact	2.18	high_impact	0.38	0.8	28.52	7.15	0.34	N	0.97	polymorphism	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6052	6052	A	C	MI.2185	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	149	50	N	T	aAc/aCc	5.22	1	0	benign	0.09	deleterious	0	neutral	2.88	neutral	-0.26	neutral	-1.65	medium_impact	2.68	0.57	damaging	0.67	neutral	1.54	13.55	neutral	0.72	0.75	0.17	neutral	0.8	disease	0.6	disease	0.75	disease	5	1	deleterious	0.46	neutral	1	deleterious	0.21	neutral	0.19	medium_impact	-1.48	low_impact	1.38	medium_impact	0.46	0.9	12.87	67.9	0.52	P	0.24	disease_causing	0.53	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13549	13549	A	T	MI.21850	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1213	405	N	Y	Aac/Tac	-1.67	0	0	probably_damaging	1	neutral	1	neutral	3.54	neutral	-2.17	deleterious	-7.18	high_impact	4.19	0.62	neutral	0.11	damaging	3.84	23.40	deleterious	0.39	0.5	0.58	disease	0.88	disease	0.77	disease	0.8	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.83	deleterious	-3.6	low_impact	1.89	high_impact	2.62	high_impact	0.29	0.8	28.52	7.15	0.32	N	0.99	polymorphism	0.85	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13549	13549	A	G	MI.21851	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1213	405	N	D	Aac/Gac	-1.67	0	0	probably_damaging	1	neutral	0.21	neutral	3.57	neutral	-1.62	deleterious	-4.49	high_impact	3.77	0.6	damaging	0.13	damaging	3.97	23.60	deleterious	0.58	0.65	0.76	disease	0.79	disease	0.72	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.09	medium_impact	2.24	high_impact	0.40	0.8	28.52	7.15	0.32	N	0.93	polymorphism	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13550	13550	A	C	MI.21852	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1214	405	N	T	aAc/aCc	8.42	1	0	probably_damaging	1	neutral	0.42	neutral	3.58	neutral	-1.6	deleterious	-5.39	high_impact	3.64	0.63	neutral	0.11	damaging	3.44	23.00	deleterious	0.49	0.55	0.53	disease	0.81	disease	0.73	disease	0.73	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.16	medium_impact	2.12	high_impact	0.39	0.8	28.52	7.15	0.53	P	0.94	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13550	13550	A	G	MI.21853	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1214	405	N	S	aAc/aGc	8.42	1	0	probably_damaging	1	neutral	0.47	neutral	3.64	neutral	-0.79	deleterious	-4.49	medium_impact	2.73	0.64	neutral	0.14	damaging	3.13	22.60	deleterious	0.52	0.6	0.67	disease	0.78	disease	0.66	disease	0.55	disease	1	0.99	deleterious	0.24	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.2	medium_impact	1.29	medium_impact	0.22	0.8	28.52	7.15	0.48	N	0.76	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13550	13550	A	T	MI.21854	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1214	405	N	I	aAc/aTc	8.42	1	0	probably_damaging	1	neutral	0.41	neutral	3.56	neutral	-1.79	deleterious	-8.08	high_impact	4.19	0.63	neutral	0.16	damaging	3.94	23.50	deleterious	0.34	0.5	0.49	neutral	0.91	disease	0.73	disease	0.66	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.15	medium_impact	2.62	high_impact	0.17	0.8	28.52	7.15	0.59	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13551	13551	C	A	MI.21855	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1215	405	N	K	aaC/aaA	8.42	1	0	probably_damaging	1	neutral	0.31	neutral	3.59	neutral	-1.36	deleterious	-5.38	high_impact	3.7	0.58	damaging	0.13	damaging	4.58	24.40	deleterious	0.57	0.65	0.77	disease	0.85	disease	0.8	disease	0.8	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.04	medium_impact	2.18	high_impact	0.41	0.8	28.52	7.15	0.58	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13551	13551	C	G	MI.21856	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1215	405	N	K	aaC/aaG	8.42	1	0	probably_damaging	1	neutral	0.31	neutral	3.59	neutral	-1.36	deleterious	-5.38	high_impact	3.7	0.58	damaging	0.13	damaging	4.10	23.70	deleterious	0.57	0.65	0.77	disease	0.85	disease	0.8	disease	0.8	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.04	medium_impact	2.18	high_impact	0.41	0.8	28.52	7.15	0.58	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13552	13552	G	T	MI.21857	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1216	406	A	S	Gcc/Tcc	0.63	0.99	0	possibly_damaging	0.6	neutral	0.41	neutral	3.7	neutral	-1.32	deleterious	-2.55	neutral_impact	0.4	0.79	neutral	0.71	neutral	0.89	10.04	neutral	0.47	0.55	0.5	disease	0.59	disease	0.31	neutral	0.45	neutral	1	0.63	neutral	0.41	neutral	-3	neutral	0.45	deleterious	-0.91	medium_impact	0.15	medium_impact	-0.84	medium_impact	0.84	0.9	16.25	15.48	0.33	N	0.32	disease_causing	0.64	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13552	13552	G	C	MI.21858	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1216	406	A	P	Gcc/Ccc	0.63	0.99	0	probably_damaging	0.94	neutral	0.21	neutral	3.68	neutral	-1.48	deleterious	-4.36	medium_impact	2.37	0.63	neutral	0.33	neutral	3.74	23.30	deleterious	0.2	0.45	0.78	disease	0.92	disease	0.77	disease	0.82	disease	6	0.96	neutral	0.14	neutral	1	deleterious	0.80	deleterious	-1.88	low_impact	-0.09	medium_impact	0.96	medium_impact	0.85	0.9	16.25	15.48	0.38	N	0.92	disease_causing	0.93	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13552	13552	G	A	MI.21859	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1216	406	A	T	Gcc/Acc	0.63	0.99	0	benign	0.11	neutral	0.4	neutral	3.7	neutral	-1.38	deleterious	-3.29	low_impact	1.42	0.83	neutral	0.9	neutral	1.43	12.95	neutral	0.46	0.55	0.54	disease	0.6	disease	0.32	neutral	0.48	neutral	0	0.54	neutral	0.65	deleterious	-6	neutral	0.21	neutral	0.12	medium_impact	0.14	medium_impact	0.09	medium_impact	0.73	0.85	16.25	15.48	0.41	N	0.32	disease_causing	0.8	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6053	6053	C	A	MI.2186	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	150	50	N	K	aaC/aaA	5.91	1	0	benign	0.09	deleterious	0	neutral	2.86	neutral	0.51	neutral	-1.68	high_impact	3.54	0.59	damaging	0.5	neutral	2.57	19.94	deleterious	0.81	0.85	0.27	neutral	0.86	disease	0.64	disease	0.78	disease	6	1	deleterious	0.46	neutral	2	deleterious	0.27	neutral	0.19	medium_impact	-1.48	low_impact	2.17	high_impact	0.58	0.9	12.87	67.9	0.54	P	0.52	disease_causing	0.82	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13553	13553	C	T	MI.21860	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1217	406	A	V	gCc/gTc	0.86	1	0	possibly_damaging	0.6	neutral	0.5	neutral	3.72	neutral	-0.74	deleterious	-3.46	medium_impact	2.13	0.76	neutral	0.55	neutral	2.88	21.70	deleterious	0.31	0.45	0.84	disease	0.78	disease	0.66	disease	0.72	disease	4	0.58	neutral	0.45	neutral	0	NA	0.56	deleterious	-0.91	medium_impact	0.23	medium_impact	0.74	medium_impact	0.82	0.85	16.25	15.48	0.37	N	0.54	disease_causing	0.9	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13553	13553	C	A	MI.21861	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1217	406	A	D	gCc/gAc	0.86	1	0	probably_damaging	0.92	neutral	0.21	neutral	3.6	deleterious	-3.87	deleterious	-5.22	medium_impact	3.02	0.68	neutral	0.37	neutral	4.41	24.10	deleterious	0.25	0.45	0.57	disease	0.92	disease	0.78	disease	0.83	disease	6	0.95	neutral	0.15	neutral	1	deleterious	0.72	deleterious	-1.75	low_impact	-0.09	medium_impact	1.56	medium_impact	0.57	0.8	16.25	15.48	0.4	N	0.98	disease_causing	0.97	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13553	13553	C	G	MI.21862	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1217	406	A	G	gCc/gGc	0.86	1	0	possibly_damaging	0.68	neutral	0.33	neutral	3.68	neutral	-0.88	deleterious	-3.52	medium_impact	2.02	0.78	neutral	0.61	neutral	2.41	18.90	deleterious	0.3	0.45	0.67	disease	0.77	disease	0.64	disease	0.59	disease	2	0.74	neutral	0.33	neutral	0	NA	0.53	deleterious	-1.06	low_impact	0.06	medium_impact	0.64	medium_impact	0.71	0.85	16.25	15.48	0.33	N	0.60	disease_causing	0.87	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13555	13555	T	C	MI.21863	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1219	407	W	R	Tga/Cga	2	1	0	probably_damaging	1	neutral	0.34	neutral	3.5	deleterious	-4.82	deleterious	-12.59	medium_impact	3.5	0.7	neutral	0.1	damaging	3.63	23.20	deleterious	0.28	0.45	0.59	disease	0.92	disease	0.86	disease	0.86	disease	7	1	deleterious	0.17	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.07	medium_impact	1.99	medium_impact	0.38	0.8	27.86	7.14	0.45	N	0.97	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13555	13555	T	G	MI.21864	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1219	407	W	G	Tga/Gga	2	1	0	probably_damaging	1	neutral	0.36	neutral	3.53	neutral	-2.67	deleterious	-11.69	medium_impact	3.08	0.74	neutral	0.17	damaging	4.00	23.60	deleterious	0.26	0.45	0.64	disease	0.88	disease	0.82	disease	0.78	disease	6	1	deleterious	0.18	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.1	medium_impact	1.61	medium_impact	0.37	0.8	27.86	7.14	0.41	N	0.98	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13556	13556	G	C	MI.21865	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1220	407	W	S	tGa/tCa	4.52	1	0	probably_damaging	1	neutral	0.52	neutral	3.51	deleterious	-3.86	deleterious	-12.59	medium_impact	2.85	0.79	neutral	0.13	damaging	4.11	23.70	deleterious	0.24	0.45	0.56	disease	0.9	disease	0.81	disease	0.78	disease	6	1	deleterious	0.26	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.25	medium_impact	1.4	medium_impact	0.28	0.8	27.86	7.14	0.4	N	0.96	disease_causing	1	0.07	.	.	.	.	.	.	COSM1720929	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13556	13556	G	T	MI.21866	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1220	407	W	L	tGa/tTa	4.52	1	0	probably_damaging	1	neutral	0.75	neutral	3.66	neutral	-1.64	deleterious	-11.69	low_impact	1.12	0.75	neutral	0.23	damaging	4.38	24.10	deleterious	0.26	0.45	0.55	disease	0.85	disease	0.79	disease	0.64	disease	3	1	deleterious	0.38	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.5	medium_impact	-0.18	medium_impact	0.33	0.8	27.86	7.14	0.38	N	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13557	13557	A	T	MI.21867	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1221	407	W	C	tgA/tgT	7.04	1	0	probably_damaging	1	neutral	0.19	neutral	3.49	deleterious	-5.51	deleterious	-11.69	medium_impact	2.73	0.73	neutral	0.15	damaging	4.23	23.90	deleterious	0.24	0.45	0.69	disease	0.9	disease	0.8	disease	0.66	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.12	medium_impact	1.29	medium_impact	0.33	0.8	27.86	7.14	0.42	N	0.98	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13557	13557	A	C	MI.21868	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1221	407	W	C	tgA/tgC	7.04	1	0	probably_damaging	1	neutral	0.19	neutral	3.49	deleterious	-5.51	deleterious	-11.69	medium_impact	2.73	0.73	neutral	0.15	damaging	4.13	23.80	deleterious	0.24	0.45	0.69	disease	0.9	disease	0.8	disease	0.66	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.12	medium_impact	1.29	medium_impact	0.33	0.8	27.86	7.14	0.41	N	0.98	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13558	13558	G	T	MI.21869	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1222	408	A	S	Gcc/Tcc	2	1	0	probably_damaging	1	neutral	0.52	neutral	3.52	neutral	-2.39	deleterious	-2.7	low_impact	1.81	0.49	damaging	0.08	damaging	3.84	23.40	deleterious	0.31	0.5	0.38	neutral	0.8	disease	0.58	disease	0.53	disease	1	1	deleterious	0.26	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.25	medium_impact	0.45	medium_impact	0.84	0.9	27.03	7.15	0.37	N	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6053	6053	C	G	MI.2187	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	150	50	N	K	aaC/aaG	5.91	1	0	benign	0.09	deleterious	0	neutral	2.86	neutral	0.51	neutral	-1.68	high_impact	3.54	0.59	damaging	0.5	neutral	2.11	16.91	deleterious	0.81	0.85	0.27	neutral	0.86	disease	0.64	disease	0.78	disease	6	1	deleterious	0.46	neutral	2	deleterious	0.27	neutral	0.19	medium_impact	-1.48	low_impact	2.17	high_impact	0.58	0.9	12.87	67.9	0.54	P	0.52	disease_causing	0.82	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13558	13558	G	A	MI.21870	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1222	408	A	T	Gcc/Acc	2	1	0	probably_damaging	1	neutral	0.44	neutral	3.53	neutral	-2.36	deleterious	-3.6	medium_impact	2.92	0.46	damaging	0.07	damaging	4.30	24.00	deleterious	0.43	0.55	0.69	disease	0.83	disease	0.67	disease	0.66	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.18	medium_impact	1.46	medium_impact	0.76	0.85	27.03	7.15	0.46	N	0.94	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13558	13558	G	C	MI.21871	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1222	408	A	P	Gcc/Ccc	2	1	0	probably_damaging	1	neutral	0.19	neutral	3.49	neutral	-2.52	deleterious	-4.5	medium_impact	3.27	0.53	damaging	0.05	damaging	3.95	23.60	deleterious	0.11	0.4	0.73	disease	0.91	disease	0.78	disease	0.81	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	-0.12	medium_impact	1.78	medium_impact	0.86	0.9	27.03	7.15	0.45	N	0.96	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13559	13559	C	G	MI.21872	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1223	408	A	G	gCc/gGc	9.11	1	0	probably_damaging	1	neutral	0.31	neutral	3.52	neutral	-1.89	deleterious	-3.6	medium_impact	2.73	0.49	damaging	0.1	damaging	4.07	23.70	deleterious	0.18	0.45	0.39	neutral	0.78	disease	0.67	disease	0.55	disease	1	1	deleterious	0.16	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.04	medium_impact	1.29	medium_impact	0.80	0.85	27.03	7.15	0.5	P	0.84	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13559	13559	C	A	MI.21873	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1223	408	A	D	gCc/gAc	9.11	1	0	probably_damaging	1	neutral	0.23	neutral	3.44	deleterious	-5.7	deleterious	-5.4	high_impact	4.37	0.56	damaging	0.03	damaging	4.72	24.60	deleterious	0.11	0.4	0.7	disease	0.93	disease	0.77	disease	0.82	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.06	medium_impact	2.79	high_impact	0.75	0.85	27.03	7.15	0.59	P	0.95	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13559	13559	C	T	MI.21874	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1223	408	A	V	gCc/gTc	9.11	1	0	probably_damaging	1	neutral	0.51	neutral	3.59	neutral	-0.92	deleterious	-3.6	medium_impact	2.29	0.48	damaging	0.06	damaging	4.54	24.30	deleterious	0.38	0.5	0.83	disease	0.82	disease	0.67	disease	0.7	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.24	medium_impact	0.89	medium_impact	0.75	0.85	27.03	7.15	0.54	P	0.79	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13561	13561	C	A	MI.21875	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1225	409	L	M	Cta/Ata	1.08	1	0	probably_damaging	1	neutral	0.24	neutral	3.46	neutral	-2.87	neutral	-1.8	medium_impact	2.87	0.71	neutral	0.17	damaging	3.85	23.40	deleterious	0.25	0.45	0.66	disease	0.55	disease	0.52	disease	0.49	neutral	0	1	deleterious	0.12	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	-0.04	medium_impact	1.42	medium_impact	0.70	0.85	10.95	7.18	0.38	N	0.85	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13561	13561	C	G	MI.21876	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1225	409	L	V	Cta/Gta	1.08	1	0	probably_damaging	1	neutral	0.51	neutral	3.56	neutral	-1.47	deleterious	-2.7	medium_impact	2.77	0.7	neutral	0.15	damaging	3.50	23.10	deleterious	0.23	0.45	0.74	disease	0.54	disease	0.53	disease	0.51	disease	0	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.24	medium_impact	1.33	medium_impact	0.60	0.8	10.95	7.18	0.32	N	0.78	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13562	13562	T	A	MI.21877	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1226	409	L	Q	cTa/cAa	3.38	1	0	probably_damaging	1	neutral	0.29	neutral	3.42	deleterious	-5.11	deleterious	-5.39	high_impact	4.34	0.67	neutral	0.12	damaging	4.16	23.80	deleterious	0.14	0.4	0.56	disease	0.81	disease	0.64	disease	0.68	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.02	medium_impact	2.76	high_impact	0.62	0.8	10.95	7.18	0.47	N	0.98	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13562	13562	T	C	MI.21878	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1226	409	L	P	cTa/cCa	3.38	1	0	probably_damaging	1	neutral	0.21	neutral	3.43	deleterious	-4.09	deleterious	-6.29	high_impact	4	0.62	neutral	0.12	damaging	4.01	23.60	deleterious	0.13	0.4	0.4	neutral	0.84	disease	0.75	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	-0.09	medium_impact	2.45	high_impact	0.59	0.8	10.95	7.18	0.44	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13562	13562	T	G	MI.21879	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1226	409	L	R	cTa/cGa	3.38	1	0	probably_damaging	1	neutral	0.34	neutral	3.42	deleterious	-4.61	deleterious	-5.39	high_impact	4.34	0.62	neutral	0.12	damaging	4.29	24.00	deleterious	0.12	0.4	0.69	disease	0.87	disease	0.75	disease	0.81	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.07	medium_impact	2.76	high_impact	0.68	0.85	10.95	7.18	0.51	N	1.00	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6054	6054	G	C	MI.2188	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	151	51	D	H	Gac/Cac	-3.34	0	0	probably_damaging	1	deleterious	0.04	neutral	2.66	deleterious	-3.98	deleterious	-4.22	medium_impact	3	0.55	damaging	0.3	neutral	3.44	23.00	deleterious	0.46	0.55	0.4	neutral	0.87	disease	0.4	neutral	0.53	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-3.58	low_impact	-0.58	medium_impact	1.67	medium_impact	0.46	0.9	3.7	7.26	0.34	N	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13564	13564	T	A	MI.21880	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1228	410	S	T	Tct/Act	-8.77	0	0	benign	0.02	neutral	0.26	neutral	3.83	neutral	0.17	neutral	0.8	neutral_impact	-0.99	0.84	neutral	0.97	neutral	2.00	16.24	deleterious	0.22	0.45	0.51	disease	0.07	neutral	0.22	neutral	0.24	neutral	5	0.73	neutral	0.62	deleterious	-6	neutral	0.62	deleterious	0.86	medium_impact	-0.02	medium_impact	-2.11	low_impact	0.80	0.85	25.04	21	0.48	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13564	13564	T	C	MI.21881	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1228	410	S	P	Tct/Cct	-8.77	0	0	possibly_damaging	0.61	neutral	0.12	neutral	3.76	neutral	-0.59	neutral	-1.52	low_impact	1.7	0.59	damaging	0.41	neutral	3.95	23.60	deleterious	0.13	0.4	0.6	disease	0.75	disease	0.54	disease	0.69	disease	4	0.88	neutral	0.26	neutral	-3	neutral	0.78	deleterious	-0.93	medium_impact	-0.25	medium_impact	0.35	medium_impact	0.61	0.8	25.04	21	0.28	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13564	13564	T	G	MI.21882	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1228	410	S	A	Tct/Gct	-8.77	0	0	benign	0.17	neutral	0.41	neutral	3.96	neutral	1.92	neutral	0.08	neutral_impact	-0.34	0.79	neutral	0.82	neutral	2.48	19.35	deleterious	0.26	0.45	0.44	neutral	0.11	neutral	0.26	neutral	0.32	neutral	4	0.51	neutral	0.62	deleterious	-6	neutral	0.61	deleterious	-0.09	medium_impact	0.15	medium_impact	-1.51	low_impact	0.71	0.85	25.04	21	0.42	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13565	13565	C	G	MI.21883	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1229	410	S	C	tCt/tGt	-14.96	0	0	benign	0.02	neutral	0.12	neutral	3.73	neutral	-2.38	neutral	-0.34	neutral_impact	0.73	0.84	neutral	0.79	neutral	2.51	19.56	deleterious	0.15	0.4	0.76	disease	0.52	disease	0.29	neutral	0.5	neutral	0	0.88	neutral	0.55	deleterious	-6	neutral	0.72	deleterious	0.86	medium_impact	-0.25	medium_impact	-0.54	medium_impact	0.68	0.85	25.04	21	0.36	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13565	13565	C	A	MI.21884	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1229	410	S	Y	tCt/tAt	-14.96	0	0	benign	0.37	neutral	0.53	neutral	3.75	neutral	-0.85	neutral	-0.62	neutral_impact	0.76	0.82	neutral	0.6	neutral	2.93	22.00	deleterious	0.19	0.45	0.32	neutral	0.47	neutral	0.43	neutral	0.5	neutral	0	0.4	neutral	0.58	deleterious	-6	neutral	0.65	deleterious	-0.53	medium_impact	0.26	medium_impact	-0.51	medium_impact	0.68	0.85	25.04	21	0.27	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13565	13565	C	T	MI.21885	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1229	410	S	F	tCt/tTt	-14.96	0	0	benign	0.01	neutral	0.46	neutral	3.81	neutral	-0.08	neutral	0	neutral_impact	-0.35	0.89	neutral	0.94	neutral	2.86	21.70	deleterious	0.21	0.45	0.33	neutral	0.52	disease	0.35	neutral	0.44	neutral	1	0.53	neutral	0.73	deleterious	-6	neutral	0.66	deleterious	1.15	medium_impact	0.19	medium_impact	-1.52	low_impact	0.46	0.8	25.04	21	0.31	N	0.08	polymorphism	1	0.01	rs56039545	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13567	13567	A	G	MI.21886	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1231	411	I	V	Att/Gtt	-3.5	0	0	benign	0	neutral	0.53	neutral	3.69	neutral	-0.1	neutral	-0.54	low_impact	1.23	0.87	neutral	0.93	neutral	1.15	11.50	neutral	0.45	0.55	0.46	neutral	0.22	neutral	0.36	neutral	0.42	neutral	2	0.46	neutral	0.77	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.26	medium_impact	-0.08	medium_impact	0.50	0.8	13.43	12.4	0.33	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13567	13567	A	C	MI.21887	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1231	411	I	L	Att/Ctt	-3.5	0	0	benign	0.01	neutral	0.76	neutral	3.9	neutral	0.17	neutral	-0.82	neutral_impact	-0.39	0.8	neutral	0.93	neutral	-0.75	0.06	neutral	0.28	0.45	0.38	neutral	0.11	neutral	0.2	neutral	0.28	neutral	4	0.22	neutral	0.88	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	0.51	medium_impact	-1.56	low_impact	0.60	0.8	13.43	12.4	0.32	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13567	13567	A	T	MI.21888	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1231	411	I	F	Att/Ttt	-3.5	0	0	benign	0.14	neutral	0.72	neutral	3.55	neutral	-2.06	deleterious	-2.81	low_impact	1.68	0.71	neutral	0.73	neutral	2.24	17.77	deleterious	0.3	0.45	0.72	disease	0.66	disease	0.5	neutral	0.53	disease	1	0.16	neutral	0.79	deleterious	-6	neutral	0.35	neutral	0	medium_impact	0.46	medium_impact	0.33	medium_impact	0.70	0.85	13.43	12.4	0.24	N	0.59	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13568	13568	T	G	MI.21889	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1232	411	I	S	aTt/aGt	-0.29	0	0	benign	0	neutral	0.46	neutral	3.51	deleterious	-3.27	deleterious	-4.04	medium_impact	2.42	0.74	neutral	0.62	neutral	2.45	19.17	deleterious	0.24	0.45	0.82	disease	0.66	disease	0.58	disease	0.69	disease	4	0.53	neutral	0.73	deleterious	-3	neutral	0.31	neutral	2.1	high_impact	0.19	medium_impact	1.01	medium_impact	0.42	0.8	13.43	12.4	0.29	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6054	6054	G	T	MI.2189	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	151	51	D	Y	Gac/Tac	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-5	deleterious	-5.46	medium_impact	3.29	0.42	damaging	0.3	neutral	3.76	23.30	deleterious	0.32	0.55	0.61	disease	0.95	disease	0.44	neutral	0.56	disease	1	1	deleterious	0	neutral	5	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	1.94	medium_impact	0.19	0.9	3.7	7.26	0.4	N	0.94	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13568	13568	T	A	MI.21890	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1232	411	I	N	aTt/aAt	-0.29	0	0	benign	0.14	neutral	0.39	neutral	3.48	deleterious	-4.99	deleterious	-4.93	medium_impact	2.83	0.68	neutral	0.41	neutral	2.71	20.80	deleterious	0.22	0.45	0.92	disease	0.76	disease	0.6	disease	0.82	disease	6	0.54	neutral	0.63	deleterious	-3	neutral	0.53	deleterious	0	medium_impact	0.13	medium_impact	1.38	medium_impact	0.60	0.8	13.43	12.4	0.26	N	0.91	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13568	13568	T	C	MI.21891	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1232	411	I	T	aTt/aCt	-0.29	0	0	benign	0	neutral	0.44	neutral	3.52	neutral	-2.82	deleterious	-2.9	low_impact	0.88	0.9	neutral	0.97	neutral	0.18	4.43	deleterious	0.4	0.5	0.81	disease	0.33	neutral	0.39	neutral	0.65	disease	3	0.56	neutral	0.72	deleterious	-6	neutral	0.23	neutral	2.1	high_impact	0.18	medium_impact	-0.4	medium_impact	0.48	0.8	13.43	12.4	0.36	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13569	13569	T	G	MI.21892	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1233	411	I	M	atT/atG	2.92	0.13	0	benign	0.01	neutral	0.26	neutral	3.57	neutral	-2.3	neutral	-1.39	neutral_impact	0.13	0.87	neutral	0.94	neutral	0.11	3.74	deleterious	0.33	0.5	0.67	disease	0.24	neutral	0.29	neutral	0.56	disease	1	0.73	neutral	0.63	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	-0.02	medium_impact	-1.08	low_impact	0.71	0.85	13.43	12.4	0.44	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13569	13569	T	A	MI.21893	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1233	411	I	M	atT/atA	2.92	0.13	0	benign	0.01	neutral	0.26	neutral	3.57	neutral	-2.3	neutral	-1.39	neutral_impact	0.13	0.87	neutral	0.94	neutral	0.41	6.66	deleterious	0.33	0.5	0.67	disease	0.24	neutral	0.29	neutral	0.56	disease	1	0.73	neutral	0.63	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	-0.02	medium_impact	-1.08	low_impact	0.71	0.85	13.43	12.4	0.44	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13570	13570	A	G	MI.21894	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1234	412	T	A	Act/Gct	-9.46	0	0	benign	0.42	neutral	0.65	neutral	3.88	neutral	1.35	deleterious	-4.49	medium_impact	2.24	0.65	neutral	0.53	neutral	1.79	14.95	neutral	0.42	0.5	0.34	neutral	0.49	neutral	0.66	disease	0.46	neutral	1	0.35	neutral	0.62	deleterious	-3	neutral	0.34	neutral	-0.61	medium_impact	0.38	medium_impact	0.84	medium_impact	0.51	0.8	19.73	7.34	0.35	N	0.67	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13570	13570	A	T	MI.21895	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1234	412	T	S	Act/Tct	-9.46	0	0	possibly_damaging	0.66	neutral	0.49	neutral	3.66	neutral	-1.34	deleterious	-3.59	medium_impact	2.92	0.7	neutral	0.5	neutral	1.74	14.63	neutral	0.3	0.45	0.78	disease	0.68	disease	0.63	disease	0.62	disease	2	0.64	neutral	0.42	neutral	0	NA	0.52	deleterious	-1.02	low_impact	0.22	medium_impact	1.46	medium_impact	0.68	0.85	19.73	7.34	0.26	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13570	13570	A	C	MI.21896	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1234	412	T	P	Act/Cct	-9.46	0	0	probably_damaging	0.92	neutral	0.21	neutral	3.62	neutral	-2.32	deleterious	-5.39	high_impact	4.28	0.66	neutral	0.38	neutral	3.38	23.00	deleterious	0.11	0.4	0.9	disease	0.84	disease	0.78	disease	0.85	disease	7	0.95	neutral	0.15	neutral	2	deleterious	0.77	deleterious	-1.75	low_impact	-0.09	medium_impact	2.71	high_impact	0.52	0.8	19.73	7.34	0.47	N	0.97	polymorphism	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13571	13571	C	A	MI.21897	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1235	412	T	N	aCt/aAt	6.81	1	0	probably_damaging	0.92	neutral	0.34	neutral	3.61	deleterious	-3.5	deleterious	-4.49	high_impact	4.28	0.65	neutral	0.45	neutral	3.49	23.10	deleterious	0.39	0.5	0.88	disease	0.82	disease	0.6	disease	0.75	disease	5	0.93	neutral	0.21	neutral	2	deleterious	0.73	deleterious	-1.75	low_impact	0.07	medium_impact	2.71	high_impact	0.77	0.85	19.73	7.34	0.59	P	0.93	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13571	13571	C	G	MI.21898	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1235	412	T	S	aCt/aGt	6.81	1	0	possibly_damaging	0.66	neutral	0.49	neutral	3.66	neutral	-1.34	deleterious	-3.59	medium_impact	2.92	0.7	neutral	0.5	neutral	1.94	15.83	deleterious	0.3	0.45	0.78	disease	0.68	disease	0.63	disease	0.62	disease	2	0.64	neutral	0.42	neutral	0	NA	0.52	deleterious	-1.02	low_impact	0.22	medium_impact	1.46	medium_impact	0.68	0.85	19.73	7.34	0.55	P	0.85	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13571	13571	C	T	MI.21899	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1235	412	T	I	aCt/aTt	6.81	1	0	benign	0.05	neutral	0.44	neutral	3.72	neutral	-0.1	deleterious	-5.39	medium_impact	2.56	0.66	neutral	0.56	neutral	2.06	16.62	deleterious	0.24	0.45	0.63	disease	0.82	disease	0.59	disease	0.65	disease	3	0.52	neutral	0.7	deleterious	-3	neutral	0.25	neutral	0.47	medium_impact	0.18	medium_impact	1.14	medium_impact	0.58	0.8	19.73	7.34	0.51	N	0.92	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8629	8629	A	C	MI.219	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	103	35	K	Q	Aaa/Caa	-14.22	0	0	possibly_damaging	0.56	neutral	0.27	neutral	4.36	neutral	-0.83	neutral	-1.1	neutral_impact	0.7	0.85	neutral	0.7	neutral	1.64	14.07	neutral	0.6	0.7	0.55	disease	0.25	neutral	0.28	neutral	0.53	disease	1	0.73	neutral	0.36	neutral	-3	neutral	0.50	deleterious	-0.86	medium_impact	0.05	medium_impact	-0.5	medium_impact	0.57	0.9	20.35	18.29	0.41	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6054	6054	G	A	MI.2190	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	151	51	D	N	Gac/Aac	-3.34	0	0	probably_damaging	1	deleterious	0.03	neutral	2.7	neutral	-2.42	deleterious	-2.96	medium_impact	2.04	0.42	damaging	0.42	neutral	4.13	23.80	deleterious	0.83	0.85	0.21	neutral	0.85	disease	0.3	neutral	0.52	disease	0	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-0.65	medium_impact	0.79	medium_impact	0.68	0.9	3.7	7.26	0.45	N	0.89	disease_causing	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13573	13573	C	A	MI.21900	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1237	413	L	I	Ctc/Atc	-9	0	0	possibly_damaging	0.69	neutral	0.48	neutral	3.53	neutral	-1.81	neutral	-1.75	medium_impact	2.2	0.74	neutral	0.61	neutral	4.14	23.80	deleterious	0.29	0.45	0.6	disease	0.43	neutral	0.32	neutral	0.59	disease	2	0.67	neutral	0.4	neutral	0	NA	0.71	deleterious	-1.08	low_impact	0.21	medium_impact	0.81	medium_impact	0.66	0.8	2.16	9.23	0.32	N	0.83	polymorphism	1	0.02	rs28462226	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13573	13573	C	G	MI.21901	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1237	413	L	V	Ctc/Gtc	-9	0	0	possibly_damaging	0.69	neutral	0.58	neutral	3.57	neutral	-1.11	deleterious	-2.61	medium_impact	2.44	0.76	neutral	0.57	neutral	3.53	23.10	deleterious	0.24	0.45	0.51	disease	0.34	neutral	0.5	neutral	0.34	neutral	3	0.64	neutral	0.45	neutral	0	NA	0.68	deleterious	-1.08	low_impact	0.31	medium_impact	1.03	medium_impact	0.57	0.8	2.16	9.23	0.27	N	0.78	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13573	13573	C	T	MI.21902	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1237	413	L	F	Ctc/Ttc	-9	0	0	benign	0.14	neutral	0.75	neutral	3.48	neutral	-2.76	deleterious	-3.44	medium_impact	2.07	0.75	neutral	0.46	neutral	4.03	23.60	deleterious	0.31	0.45	0.82	disease	0.64	disease	0.52	disease	0.6	disease	2	0.14	neutral	0.81	deleterious	-3	neutral	0.77	deleterious	0	medium_impact	0.5	medium_impact	0.69	medium_impact	0.60	0.8	2.16	9.23	0.18	N	0.98	polymorphism	0.99	0.06	rs28462226	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13574	13574	T	A	MI.21903	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1238	413	L	H	cTc/cAc	-0.06	0	0	probably_damaging	0.98	neutral	0.53	neutral	3.39	deleterious	-5.89	deleterious	-6.14	high_impact	4.37	0.7	neutral	0.34	neutral	4.16	23.80	deleterious	0.13	0.4	0.94	disease	0.71	disease	0.69	disease	0.81	disease	6	0.98	neutral	0.28	neutral	2	deleterious	0.81	deleterious	-2.35	low_impact	0.26	medium_impact	2.79	high_impact	0.61	0.8	2.16	9.23	0.35	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13574	13574	T	G	MI.21904	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1238	413	L	R	cTc/cGc	-0.06	0	0	probably_damaging	0.97	neutral	0.34	neutral	3.39	deleterious	-5.38	deleterious	-5.27	high_impact	4.37	0.63	neutral	0.3	neutral	4.27	24.00	deleterious	0.11	0.4	0.92	disease	0.82	disease	0.72	disease	0.82	disease	6	0.97	neutral	0.19	neutral	2	deleterious	0.87	deleterious	-2.18	low_impact	0.07	medium_impact	2.79	high_impact	0.50	0.8	2.16	9.23	0.4	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13574	13574	T	C	MI.21905	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1238	413	L	P	cTc/cCc	-0.06	0	0	probably_damaging	0.98	neutral	0.22	neutral	3.39	deleterious	-5.85	deleterious	-6.17	high_impact	4.37	0.66	neutral	0.32	neutral	3.99	23.60	deleterious	0.12	0.4	0.94	disease	0.8	disease	0.73	disease	0.83	disease	7	0.99	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	-0.07	medium_impact	2.79	high_impact	0.60	0.8	2.16	9.23	0.39	N	0.99	polymorphism	0.75	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13576	13576	A	G	MI.21906	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1240	414	I	V	Atc/Gtc	-9.69	0	0	benign	0.01	neutral	0.53	neutral	3.73	neutral	-0.13	neutral	-0.49	neutral_impact	0.36	0.87	neutral	0.98	neutral	1.74	14.63	neutral	0.53	0.6	0.44	neutral	0.15	neutral	0.37	neutral	0.31	neutral	4	0.46	neutral	0.76	deleterious	-6	neutral	0.54	deleterious	1.15	medium_impact	0.26	medium_impact	-0.87	medium_impact	0.38	0.8	7.3	10.37	0.37	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13576	13576	A	C	MI.21907	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1240	414	I	L	Atc/Ctc	-9.69	0	0	benign	0.01	neutral	0.84	neutral	3.85	neutral	0.26	neutral	-1.27	low_impact	1.23	0.79	neutral	0.9	neutral	2.35	18.52	deleterious	0.34	0.5	0.37	neutral	0.2	neutral	0.28	neutral	0.35	neutral	3	0.13	neutral	0.92	deleterious	-6	neutral	0.55	deleterious	1.15	medium_impact	0.63	medium_impact	-0.08	medium_impact	0.49	0.8	7.3	10.37	0.34	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13576	13576	A	T	MI.21908	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1240	414	I	F	Atc/Ttc	-9.69	0	0	possibly_damaging	0.45	neutral	0.73	neutral	3.61	neutral	-1.84	deleterious	-3.21	low_impact	1.62	0.72	neutral	0.73	neutral	3.88	23.50	deleterious	0.39	0.5	0.56	disease	0.65	disease	0.52	disease	0.52	disease	0	0.35	neutral	0.64	deleterious	-3	neutral	0.71	deleterious	-0.66	medium_impact	0.47	medium_impact	0.28	medium_impact	0.59	0.8	7.3	10.37	0.24	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13577	13577	T	C	MI.21909	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1241	414	I	T	aTc/aCc	-1.67	0	0	benign	0.32	neutral	0.47	neutral	3.53	neutral	-2.64	deleterious	-3.51	low_impact	1.72	0.86	neutral	0.97	neutral	3.46	23.00	deleterious	0.46	0.55	0.77	disease	0.47	neutral	0.59	disease	0.65	disease	3	0.44	neutral	0.58	deleterious	-6	neutral	0.75	deleterious	-0.44	medium_impact	0.2	medium_impact	0.37	medium_impact	0.38	0.8	7.3	10.37	0.37	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6055	6055	A	T	MI.2191	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	152	51	D	V	gAc/gTc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.74	deleterious	-4.15	deleterious	-5.5	high_impact	3.63	0.49	damaging	0.34	neutral	4.20	23.90	deleterious	0.29	0.55	0.46	neutral	0.95	disease	0.61	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.25	high_impact	0.21	0.9	3.7	7.26	0.47	N	0.93	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13577	13577	T	G	MI.21910	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1241	414	I	S	aTc/aGc	-1.67	0	0	possibly_damaging	0.53	neutral	0.51	neutral	3.53	deleterious	-3.29	deleterious	-4.61	medium_impact	2.38	0.75	neutral	0.47	neutral	4.40	24.10	deleterious	0.29	0.45	0.7	disease	0.73	disease	0.61	disease	0.68	disease	4	0.52	neutral	0.49	deleterious	0	NA	0.77	deleterious	-0.8	medium_impact	0.24	medium_impact	0.97	medium_impact	0.38	0.8	7.3	10.37	0.24	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13577	13577	T	A	MI.21911	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1241	414	I	N	aTc/aAc	-1.67	0	0	possibly_damaging	0.84	neutral	0.37	neutral	3.48	deleterious	-5.1	deleterious	-5.53	high_impact	3.88	0.7	neutral	0.41	neutral	4.59	24.40	deleterious	0.23	0.45	0.92	disease	0.78	disease	0.63	disease	0.8	disease	6	0.85	neutral	0.27	neutral	1	deleterious	0.81	deleterious	-1.43	low_impact	0.11	medium_impact	2.34	high_impact	0.40	0.8	7.3	10.37	0.33	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13578	13578	C	A	MI.21912	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1242	414	I	M	atC/atA	2.46	0.04	0	benign	0.07	neutral	0.27	neutral	3.54	deleterious	-3.03	neutral	-1.98	low_impact	1.49	0.83	neutral	0.91	neutral	2.87	21.70	deleterious	0.38	0.5	0.75	disease	0.36	neutral	0.36	neutral	0.65	disease	3	0.7	neutral	0.6	deleterious	-6	neutral	0.71	deleterious	0.32	medium_impact	-0.01	medium_impact	0.16	medium_impact	0.61	0.8	7.3	10.37	0.45	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13578	13578	C	G	MI.21913	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1242	414	I	M	atC/atG	2.46	0.04	0	benign	0.07	neutral	0.27	neutral	3.54	deleterious	-3.03	neutral	-1.98	low_impact	1.49	0.83	neutral	0.91	neutral	2.38	18.66	deleterious	0.38	0.5	0.75	disease	0.36	neutral	0.36	neutral	0.65	disease	3	0.7	neutral	0.6	deleterious	-6	neutral	0.71	deleterious	0.32	medium_impact	-0.01	medium_impact	0.16	medium_impact	0.61	0.8	7.3	10.37	0.45	N	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13579	13579	G	A	MI.21914	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1243	415	A	T	Gct/Act	-7.17	0	0	benign	0.16	neutral	0.46	neutral	3.59	neutral	-1.61	deleterious	-3.45	medium_impact	2.18	0.52	damaging	0.46	neutral	4.26	23.90	deleterious	0.43	0.55	0.38	neutral	0.71	disease	0.59	disease	0.61	disease	2	0.45	neutral	0.65	deleterious	-3	neutral	0.72	deleterious	-0.06	medium_impact	0.19	medium_impact	0.79	medium_impact	0.70	0.85	18.24	7.08	0.36	N	0.50	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13579	13579	G	C	MI.21915	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1243	415	A	P	Gct/Cct	-7.17	0	0	probably_damaging	0.96	neutral	0.22	neutral	3.47	deleterious	-5.48	deleterious	-4.41	high_impact	4.47	0.55	damaging	0.38	neutral	3.89	23.50	deleterious	0.16	0.45	0.9	disease	0.86	disease	0.79	disease	0.85	disease	7	0.97	neutral	0.13	neutral	2	deleterious	0.87	deleterious	-2.06	low_impact	-0.07	medium_impact	2.88	high_impact	0.76	0.85	18.24	7.08	0.53	N	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13579	13579	G	T	MI.21916	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1243	415	A	S	Gct/Tct	-7.17	0	0	possibly_damaging	0.69	neutral	0.48	neutral	3.67	neutral	-1.87	deleterious	-2.56	low_impact	1.35	0.61	neutral	0.65	neutral	3.77	23.40	deleterious	0.45	0.55	0.43	neutral	0.69	disease	0.58	disease	0.49	neutral	0	0.67	neutral	0.4	neutral	-3	neutral	0.75	deleterious	-1.08	low_impact	0.21	medium_impact	0.03	medium_impact	0.79	0.85	18.24	7.08	0.3	N	0.67	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13580	13580	C	T	MI.21917	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1244	415	A	V	gCt/gTt	5.9	1	0	possibly_damaging	0.69	neutral	0.45	neutral	3.56	neutral	-1.54	deleterious	-3.54	medium_impact	3.15	0.53	damaging	0.4	neutral	4.51	24.30	deleterious	0.41	0.5	0.53	disease	0.76	disease	0.66	disease	0.68	disease	4	0.68	neutral	0.38	neutral	0	NA	0.75	deleterious	-1.08	low_impact	0.18	medium_impact	1.67	medium_impact	0.71	0.85	18.24	7.08	0.66	P	0.63	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13580	13580	C	G	MI.21918	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1244	415	A	G	gCt/gGt	5.9	1	0	possibly_damaging	0.81	neutral	0.32	neutral	3.7	neutral	-0.41	deleterious	-3.53	medium_impact	2.27	0.55	damaging	0.5	neutral	4.08	23.70	deleterious	0.38	0.5	0.46	neutral	0.76	disease	0.64	disease	0.61	disease	2	0.84	neutral	0.26	neutral	0	NA	0.72	deleterious	-1.34	low_impact	0.05	medium_impact	0.87	medium_impact	0.73	0.85	18.24	7.08	0.6	P	0.70	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	C13580G	Thyroid Cancer	-	+	Reported	1	.	P	P	neutral
chrM	13580	13580	C	A	MI.21919	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1244	415	A	D	gCt/gAt	5.9	1	0	probably_damaging	0.94	neutral	0.23	neutral	3.46	deleterious	-5.81	deleterious	-5.26	high_impact	4.47	0.59	damaging	0.41	neutral	4.55	24.40	deleterious	0.14	0.4	0.89	disease	0.9	disease	0.78	disease	0.86	disease	7	0.96	neutral	0.15	neutral	2	deleterious	0.85	deleterious	-1.88	low_impact	-0.06	medium_impact	2.88	high_impact	0.56	0.8	18.24	7.08	0.65	P	0.96	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6055	6055	A	G	MI.2192	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	152	51	D	G	gAc/gGc	6.14	1	0	probably_damaging	1	neutral	0.21	neutral	2.65	deleterious	-3.24	deleterious	-4.25	medium_impact	2.25	0.46	damaging	0.48	neutral	4.43	24.20	deleterious	0.46	0.55	0.3	neutral	0.86	disease	0.4	neutral	0.53	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.13	medium_impact	0.98	medium_impact	0.40	0.9	3.7	7.26	0.58	P	0.85	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13582	13582	A	T	MI.21920	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1246	416	T	S	Acc/Tcc	-3.27	0	0	probably_damaging	1	neutral	0.46	neutral	3.7	neutral	0.61	deleterious	-3.53	medium_impact	3.21	0.6	neutral	0.59	neutral	3.93	23.50	deleterious	0.44	0.55	0.39	neutral	0.66	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.23	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.19	medium_impact	1.73	medium_impact	0.48	0.8	7.3	9.49	0.37	N	0.85	disease_causing	0.93	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13582	13582	A	C	MI.21921	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1246	416	T	P	Acc/Ccc	-3.27	0	0	probably_damaging	1	neutral	0.2	neutral	3.49	deleterious	-3.98	deleterious	-5.26	high_impact	4.66	0.61	neutral	0.41	neutral	4.07	23.70	deleterious	0.16	0.45	0.91	disease	0.8	disease	0.79	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.1	medium_impact	3.05	high_impact	0.46	0.8	7.3	9.49	0.61	P	0.97	disease_causing	0.99	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13582	13582	A	G	MI.21922	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1246	416	T	A	Acc/Gcc	-3.27	0	0	probably_damaging	1	neutral	0.57	neutral	3.78	neutral	0.86	deleterious	-4.33	medium_impact	2.13	0.69	neutral	0.73	neutral	4.07	23.70	deleterious	0.55	0.6	0.38	neutral	0.3	neutral	0.65	disease	0.42	neutral	2	0.99	deleterious	0.29	neutral	1	deleterious	0.68	deleterious	-3.6	low_impact	0.3	medium_impact	0.74	medium_impact	0.38	0.8	7.3	9.49	0.32	N	0.67	disease_causing	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13583	13583	C	A	MI.21923	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1247	416	T	N	aCc/aAc	5.67	1	0	probably_damaging	1	neutral	0.33	neutral	3.5	neutral	-2.78	deleterious	-4.42	high_impact	4.31	0.59	damaging	0.51	neutral	3.77	23.40	deleterious	0.41	0.5	0.68	disease	0.78	disease	0.7	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.06	medium_impact	2.73	high_impact	0.77	0.85	7.3	9.49	0.62	P	0.93	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13583	13583	C	T	MI.21924	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1247	416	T	I	aCc/aTc	5.67	1	0	probably_damaging	1	neutral	0.46	neutral	3.58	neutral	-1	deleterious	-5.09	medium_impact	2.72	0.6	damaging	0.56	neutral	4.07	23.70	deleterious	0.31	0.45	0.67	disease	0.8	disease	0.66	disease	0.68	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.19	medium_impact	1.28	medium_impact	0.66	0.8	7.3	9.49	0.47	N	0.92	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13583	13583	C	G	MI.21925	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1247	416	T	S	aCc/aGc	5.67	1	0	probably_damaging	1	neutral	0.46	neutral	3.7	neutral	0.61	deleterious	-3.53	medium_impact	3.21	0.6	neutral	0.59	neutral	3.60	23.20	deleterious	0.44	0.55	0.39	neutral	0.66	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.23	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.19	medium_impact	1.73	medium_impact	0.48	0.8	7.3	9.49	0.54	P	0.85	disease_causing	0.88	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13585	13585	T	G	MI.21926	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1249	417	S	A	Tcc/Gcc	-5.56	0	0	benign	0.05	neutral	0.6	neutral	3.8	neutral	0.38	deleterious	-2.56	low_impact	1.08	0.79	neutral	0.58	neutral	3.77	23.40	deleterious	0.46	0.55	0.33	neutral	0.23	neutral	0.37	neutral	0.43	neutral	2	0.34	neutral	0.78	deleterious	-6	neutral	0.63	deleterious	0.47	medium_impact	0.33	medium_impact	-0.22	medium_impact	0.55	0.8	9.78	12.8	0.26	N	0.49	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13585	13585	T	A	MI.21927	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1249	417	S	T	Tcc/Acc	-5.56	0	0	possibly_damaging	0.61	neutral	0.63	neutral	3.69	neutral	-1.47	deleterious	-2.56	low_impact	0.84	0.77	neutral	0.46	neutral	2.83	21.50	deleterious	0.37	0.5	0.7	disease	0.37	neutral	0.37	neutral	0.64	disease	3	0.54	neutral	0.51	deleterious	-3	neutral	0.70	deleterious	-0.93	medium_impact	0.36	medium_impact	-0.44	medium_impact	0.62	0.8	9.78	12.8	0.22	N	0.70	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13585	13585	T	C	MI.21928	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1249	417	S	P	Tcc/Ccc	-5.56	0	0	probably_damaging	0.92	neutral	0.19	neutral	3.63	deleterious	-3.81	deleterious	-4.38	high_impact	3.69	0.71	neutral	0.11	damaging	4.09	23.70	deleterious	0.21	0.45	0.88	disease	0.83	disease	0.73	disease	0.79	disease	6	0.95	neutral	0.14	neutral	2	deleterious	0.84	deleterious	-1.75	low_impact	-0.12	medium_impact	2.17	high_impact	0.49	0.8	9.78	12.8	0.31	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13586	13586	C	G	MI.21929	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1250	417	S	C	tCc/tGc	0.17	0.01	0	probably_damaging	0.96	neutral	0.17	neutral	3.63	deleterious	-3.47	deleterious	-4.34	medium_impact	2.25	0.69	neutral	0.1	damaging	3.73	23.30	deleterious	0.28	0.45	0.87	disease	0.71	disease	0.51	disease	0.66	disease	3	0.98	neutral	0.11	neutral	1	deleterious	0.76	deleterious	-2.06	low_impact	-0.15	medium_impact	0.85	medium_impact	0.55	0.8	9.78	12.8	0.28	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6055	6055	A	C	MI.2193	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	152	51	D	A	gAc/gCc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-2.71	deleterious	-4.87	medium_impact	3.43	0.63	neutral	0.42	neutral	4.02	23.60	deleterious	0.43	0.55	0.2	neutral	0.9	disease	0.52	disease	0.67	disease	3	1	deleterious	0	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.07	high_impact	0.36	0.9	3.7	7.26	0.49	P	0.85	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13586	13586	C	A	MI.21930	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1250	417	S	Y	tCc/tAc	0.17	0.01	0	probably_damaging	0.96	neutral	0.98	neutral	3.65	neutral	-2.91	deleterious	-5.22	medium_impact	3	0.76	neutral	0.12	damaging	4.15	23.80	deleterious	0.24	0.45	0.8	disease	0.75	disease	0.63	disease	0.71	disease	4	0.96	neutral	0.51	deleterious	1	deleterious	0.78	deleterious	-2.06	low_impact	1.17	medium_impact	1.54	medium_impact	0.63	0.8	9.78	12.8	0.18	N	0.99	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13586	13586	C	T	MI.21931	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1250	417	S	F	tCc/tTc	0.17	0.01	0	probably_damaging	0.94	neutral	0.69	neutral	3.73	neutral	-0.38	deleterious	-5.2	low_impact	1.6	0.75	neutral	0.13	damaging	4.38	24.10	deleterious	0.35	0.5	0.46	neutral	0.76	disease	0.64	disease	0.56	disease	1	0.93	neutral	0.38	neutral	-2	neutral	0.72	deleterious	-1.88	low_impact	0.42	medium_impact	0.26	medium_impact	0.36	0.8	9.78	12.8	0.18	N	0.99	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13588	13588	C	A	MI.21932	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1252	418	L	M	Ctg/Atg	-11.98	0	0	possibly_damaging	0.44	neutral	0.24	neutral	3.18	deleterious	-3.25	neutral	-0.02	low_impact	1.36	0.78	neutral	0.91	neutral	2.38	18.67	deleterious	0.29	0.45	0.76	disease	0.38	neutral	0.33	neutral	0.66	disease	3	0.73	neutral	0.4	neutral	-3	neutral	0.74	deleterious	-0.65	medium_impact	-0.04	medium_impact	0.04	medium_impact	0.73	0.85	13.43	16.18	0.43	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13588	13588	C	G	MI.21933	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1252	418	L	V	Ctg/Gtg	-11.98	0	0	possibly_damaging	0.69	neutral	0.5	neutral	3.25	neutral	-2.25	neutral	-1.91	medium_impact	2.95	0.61	neutral	0.62	neutral	3.53	23.10	deleterious	0.28	0.45	0.73	disease	0.53	disease	0.61	disease	0.64	disease	3	0.66	neutral	0.41	neutral	0	NA	0.76	deleterious	-1.08	low_impact	0.23	medium_impact	1.49	medium_impact	0.52	0.8	13.43	16.18	0.35	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13589	13589	T	G	MI.21934	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1253	418	L	R	cTg/cGg	-0.52	0	0	probably_damaging	0.94	neutral	0.35	neutral	3.12	deleterious	-5.91	deleterious	-4.21	high_impact	4.24	0.61	neutral	0.48	neutral	4.28	24.00	deleterious	0.12	0.4	0.93	disease	0.87	disease	0.74	disease	0.85	disease	7	0.95	neutral	0.21	neutral	2	deleterious	0.90	deleterious	-1.88	low_impact	0.08	medium_impact	2.67	high_impact	0.36	0.8	13.43	16.18	0.42	N	0.93	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13589	13589	T	C	MI.21935	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1253	418	L	P	cTg/cCg	-0.52	0	0	probably_damaging	0.98	neutral	0.2	neutral	3.12	deleterious	-6.34	deleterious	-5.11	high_impact	4.24	0.51	damaging	0.37	neutral	3.97	23.60	deleterious	0.14	0.4	0.95	disease	0.88	disease	0.74	disease	0.86	disease	7	0.99	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-2.35	low_impact	-0.1	medium_impact	2.67	high_impact	0.58	0.8	13.43	16.18	0.43	N	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13589	13589	T	A	MI.21936	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1253	418	L	Q	cTg/cAg	-0.52	0	0	probably_damaging	0.97	neutral	0.29	neutral	3.12	deleterious	-6.09	deleterious	-3.88	high_impact	4.24	0.61	neutral	0.59	neutral	4.29	24.00	deleterious	0.14	0.4	0.88	disease	0.73	disease	0.63	disease	0.77	disease	5	0.97	neutral	0.16	neutral	2	deleterious	0.85	deleterious	-2.18	low_impact	0.02	medium_impact	2.67	high_impact	0.53	0.8	13.43	16.18	0.41	N	0.87	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13591	13591	A	T	MI.21937	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1255	419	T	S	Aca/Tca	-3.96	0	0	probably_damaging	1	neutral	0.55	neutral	3.17	neutral	-2.7	deleterious	-3.59	medium_impact	3.17	0.38	damaging	0.1	damaging	3.36	22.90	deleterious	0.3	0.45	0.59	disease	0.62	disease	0.68	disease	0.48	neutral	0	0.99	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.28	medium_impact	1.69	medium_impact	0.42	0.8	29.35	7.28	0.43	N	0.85	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13591	13591	A	C	MI.21938	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1255	419	T	P	Aca/Cca	-3.96	0	0	probably_damaging	1	neutral	0.24	neutral	3.06	deleterious	-6.23	deleterious	-5.39	high_impact	4.58	0.46	damaging	0.06	damaging	3.59	23.20	deleterious	0.17	0.45	0.96	disease	0.8	disease	0.82	disease	0.85	disease	7	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.04	medium_impact	2.98	high_impact	0.39	0.8	29.35	7.28	0.49	N	0.97	polymorphism	0.98	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13591	13591	A	G	MI.21939	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1255	419	T	A	Aca/Gca	-3.96	0	0	probably_damaging	1	neutral	0.58	neutral	3.16	neutral	-2.12	deleterious	-4.49	high_impact	4.93	0.5	damaging	0.07	damaging	3.57	23.20	deleterious	0.34	0.5	0.64	disease	0.54	disease	0.66	disease	0.66	disease	3	0.99	deleterious	0.29	neutral	2	deleterious	0.74	deleterious	-3.6	low_impact	0.31	medium_impact	3.3	high_impact	0.38	0.8	29.35	7.28	0.58	P	0.67	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6056	6056	C	G	MI.2194	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	153	51	D	E	gaC/gaG	7.07	1	0	probably_damaging	0.98	deleterious	0.02	neutral	2.76	neutral	-0.58	neutral	-2.42	medium_impact	2.48	0.49	damaging	0.33	neutral	3.74	23.30	deleterious	0.66	0.7	0.24	neutral	0.88	disease	0.3	neutral	0.54	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-2.35	low_impact	-0.75	medium_impact	1.19	medium_impact	0.38	0.9	3.7	7.26	0.55	P	0.65	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13592	13592	C	T	MI.21940	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1256	419	T	M	aCa/aTa	6.59	1	0	probably_damaging	1	neutral	0.34	neutral	3.07	deleterious	-4.78	deleterious	-5.39	high_impact	4.93	0.54	damaging	0.04	damaging	4.15	23.80	deleterious	0.29	0.45	0.97	disease	0.8	disease	0.74	disease	0.83	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.07	medium_impact	3.3	high_impact	0.64	0.8	29.35	7.28	0.68	P	0.93	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13592	13592	C	A	MI.21941	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1256	419	T	K	aCa/aAa	6.59	1	0	probably_damaging	1	neutral	0.34	neutral	3.07	deleterious	-5.32	deleterious	-5.39	high_impact	4.93	0.49	damaging	0.04	damaging	4.49	24.30	deleterious	0.14	0.4	0.93	disease	0.83	disease	0.81	disease	0.86	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.07	medium_impact	3.3	high_impact	0.61	0.8	29.35	7.28	0.73	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13594	13594	A	T	MI.21942	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1258	420	S	C	Agc/Tgc	-4.64	0	0	possibly_damaging	0.88	neutral	0.17	neutral	3.65	deleterious	-3.23	neutral	-1.03	low_impact	1.63	0.6	damaging	0.45	neutral	3.49	23.10	deleterious	0.18	0.45	0.78	disease	0.71	disease	0.54	disease	0.7	disease	4	0.93	neutral	0.15	neutral	-3	neutral	0.74	deleterious	-1.57	low_impact	-0.15	medium_impact	0.29	medium_impact	0.68	0.85	17.08	20.76	0.35	N	0.55	polymorphism	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13594	13594	A	C	MI.21943	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1258	420	S	R	Agc/Cgc	-4.64	0	0	possibly_damaging	0.7	neutral	0.36	neutral	3.64	deleterious	-3.58	neutral	-1.9	medium_impact	2.18	0.55	damaging	0.54	neutral	3.65	23.20	deleterious	0.12	0.4	0.58	disease	0.87	disease	0.7	disease	0.8	disease	6	0.74	neutral	0.33	neutral	0	NA	0.71	deleterious	-1.1	low_impact	0.1	medium_impact	0.79	medium_impact	0.70	0.85	17.08	20.76	0.31	N	0.59	polymorphism	0.97	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13594	13594	A	G	MI.21944	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1258	420	S	G	Agc/Ggc	-4.64	0	0	benign	0.01	neutral	0.37	neutral	3.69	neutral	-0.77	neutral	-1	low_impact	0.86	0.73	neutral	0.68	neutral	1.79	14.90	neutral	0.27	0.45	0.63	disease	0.61	disease	0.53	disease	0.57	disease	1	0.62	neutral	0.68	deleterious	-6	neutral	0.21	neutral	1.15	medium_impact	0.11	medium_impact	-0.42	medium_impact	0.65	0.8	17.08	20.76	0.27	N	0.05	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13595	13595	G	A	MI.21945	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1259	420	S	N	aGc/aAc	4.29	1	0	possibly_damaging	0.52	neutral	0.34	neutral	3.64	deleterious	-3.58	deleterious	-2.69	medium_impact	2.18	0.6	damaging	0.63	neutral	1.98	16.07	deleterious	0.45	0.55	0.82	disease	0.69	disease	0.56	disease	0.73	disease	5	0.64	neutral	0.41	neutral	0	NA	0.58	deleterious	-0.78	medium_impact	0.07	medium_impact	0.79	medium_impact	0.54	0.8	17.08	20.76	0.46	N	0.48	polymorphism	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13595	13595	G	T	MI.21946	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1259	420	S	I	aGc/aTc	4.29	1	0	possibly_damaging	0.63	neutral	0.44	neutral	3.72	neutral	-0.82	neutral	-1.93	low_impact	0.9	0.64	neutral	0.62	neutral	3.97	23.60	deleterious	0.27	0.45	0.42	neutral	0.8	disease	0.57	disease	0.76	disease	5	0.64	neutral	0.41	neutral	-3	neutral	0.67	deleterious	-0.97	medium_impact	0.18	medium_impact	-0.38	medium_impact	0.66	0.8	17.08	20.76	0.41	N	0.66	polymorphism	0.91	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13595	13595	G	C	MI.21947	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1259	420	S	T	aGc/aCc	4.29	1	0	benign	0.22	neutral	0.45	neutral	3.71	neutral	-0.86	neutral	-0.96	neutral_impact	-0.09	0.77	neutral	0.86	neutral	1.76	14.76	neutral	0.27	0.45	0.48	neutral	0.33	neutral	0.43	neutral	0.39	neutral	2	0.46	neutral	0.62	deleterious	-6	neutral	0.45	deleterious	-0.22	medium_impact	0.18	medium_impact	-1.29	low_impact	0.75	0.85	17.08	20.76	0.46	N	0.26	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13597	13597	G	A	MI.21948	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1261	421	A	T	Gcc/Acc	-5.79	0	0	benign	0.02	neutral	0.44	neutral	3.6	deleterious	-3.24	neutral	-1.04	low_impact	1.46	0.83	neutral	0.74	neutral	4.31	24.00	deleterious	0.46	0.55	0.7	disease	0.24	neutral	0.36	neutral	0.57	disease	1	0.54	neutral	0.71	deleterious	-6	neutral	0.71	deleterious	0.86	medium_impact	0.18	medium_impact	0.13	medium_impact	0.62	0.8	23.88	15.47	0.35	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13597	13597	G	C	MI.21949	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1261	421	A	P	Gcc/Ccc	-5.79	0	0	possibly_damaging	0.78	neutral	0.22	neutral	3.55	deleterious	-5.36	deleterious	-2.5	medium_impact	3.08	0.64	neutral	0.34	neutral	3.98	23.60	deleterious	0.13	0.4	0.92	disease	0.83	disease	0.71	disease	0.83	disease	7	0.86	neutral	0.22	neutral	0	NA	0.88	deleterious	-1.27	low_impact	-0.07	medium_impact	1.61	medium_impact	0.80	0.85	23.88	15.47	0.28	N	0.88	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6056	6056	C	A	MI.2195	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	153	51	D	E	gaC/gaA	7.07	1	0	probably_damaging	0.98	deleterious	0.02	neutral	2.76	neutral	-0.58	neutral	-2.42	medium_impact	2.48	0.49	damaging	0.33	neutral	4.05	23.70	deleterious	0.66	0.7	0.24	neutral	0.88	disease	0.3	neutral	0.54	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-2.35	low_impact	-0.75	medium_impact	1.19	medium_impact	0.38	0.9	3.7	7.26	0.55	P	0.65	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13597	13597	G	T	MI.21950	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1261	421	A	S	Gcc/Tcc	-5.79	0	0	benign	0.04	neutral	0.45	neutral	3.63	neutral	-2.95	neutral	-1.51	neutral_impact	0.76	0.85	neutral	0.96	neutral	3.81	23.40	deleterious	0.31	0.45	0.67	disease	0.47	neutral	0.54	disease	0.65	disease	3	0.52	neutral	0.71	deleterious	-6	neutral	0.75	deleterious	0.57	medium_impact	0.18	medium_impact	-0.51	medium_impact	0.75	0.85	23.88	15.47	0.32	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13598	13598	C	G	MI.21951	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1262	421	A	G	gCc/gGc	-0.75	0	0	benign	0.32	neutral	0.35	neutral	3.59	neutral	-2.92	deleterious	-2.8	medium_impact	2.19	0.83	neutral	0.61	neutral	4.13	23.80	deleterious	0.21	0.45	0.66	disease	0.55	disease	0.57	disease	0.69	disease	4	0.58	neutral	0.52	deleterious	-3	neutral	0.73	deleterious	-0.44	medium_impact	0.08	medium_impact	0.8	medium_impact	0.77	0.85	23.88	15.47	0.31	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13598	13598	C	T	MI.21952	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1262	421	A	V	gCc/gTc	-0.75	0	0	benign	0.23	neutral	0.53	neutral	3.71	neutral	-1.09	neutral	1.02	neutral_impact	-0.28	0.79	neutral	0.98	neutral	1.92	15.70	deleterious	0.39	0.5	0.49	neutral	0.15	neutral	0.27	neutral	0.2	neutral	6	0.36	neutral	0.65	deleterious	-6	neutral	0.65	deleterious	-0.25	medium_impact	0.26	medium_impact	-1.46	low_impact	0.77	0.85	23.88	15.47	0.32	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13598	13598	C	A	MI.21953	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1262	421	A	D	gCc/gAc	-0.75	0	0	possibly_damaging	0.54	neutral	0.24	neutral	3.55	deleterious	-5.99	deleterious	-3.14	medium_impact	3.08	0.69	neutral	0.41	neutral	4.69	24.60	deleterious	0.13	0.4	0.94	disease	0.8	disease	0.71	disease	0.84	disease	7	0.75	neutral	0.35	neutral	0	NA	0.84	deleterious	-0.81	medium_impact	-0.04	medium_impact	1.61	medium_impact	0.63	0.8	23.88	15.47	0.3	N	0.92	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13600	13600	T	A	MI.21954	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1264	422	Y	N	Tat/Aat	-4.87	0	0	probably_damaging	1	neutral	0.31	deleterious	-1.82	deleterious	-10.3	deleterious	-8.09	high_impact	3.94	0.22	damaging	0.42	neutral	4.18	23.80	deleterious	0.24	0.45	0.9	disease	0.82	disease	0.73	disease	0.8	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.04	medium_impact	2.4	high_impact	0.25	0.8	28.19	7.1	0.83	P	0.99	polymorphism	0.94	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13600	13600	T	C	MI.21955	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1264	422	Y	H	Tat/Cat	-4.87	0	0	probably_damaging	1	neutral	0.52	deleterious	-1.81	deleterious	-9.36	deleterious	-4.49	high_impact	3.94	0.33	damaging	0.32	neutral	3.72	23.30	deleterious	0.28	0.45	0.92	disease	0.8	disease	0.78	disease	0.86	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.25	medium_impact	2.4	high_impact	0.41	0.8	28.19	7.1	0.57	P	0.98	polymorphism	0.99	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13600	13600	T	G	MI.21956	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1264	422	Y	D	Tat/Gat	-4.87	0	0	probably_damaging	1	neutral	0.2	deleterious	-1.82	deleterious	-10.76	deleterious	-8.98	high_impact	3.94	0.37	damaging	0.38	neutral	4.13	23.80	deleterious	0.15	0.4	0.96	disease	0.88	disease	0.8	disease	0.86	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.1	medium_impact	2.4	high_impact	0.28	0.8	28.19	7.1	0.62	P	0.96	polymorphism	0.95	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13601	13601	A	T	MI.21957	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1265	422	Y	F	tAt/tTt	7.27	1	0	probably_damaging	1	neutral	0.72	deleterious	-1.76	deleterious	-7.09	deleterious	-3.59	high_impact	3.94	0.28	damaging	0.36	neutral	3.63	23.20	deleterious	0.27	0.45	0.8	disease	0.79	disease	0.68	disease	0.72	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.46	medium_impact	2.4	high_impact	0.33	0.8	28.19	7.1	0.91	P	0.80	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13601	13601	A	G	MI.21958	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1265	422	Y	C	tAt/tGt	7.27	1	0	probably_damaging	1	neutral	0.17	deleterious	-1.82	deleterious	-11.54	deleterious	-8.09	high_impact	3.94	0.3	damaging	0.28	damaging	3.70	23.30	deleterious	0.25	0.45	0.82	disease	0.84	disease	0.77	disease	0.8	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.15	medium_impact	2.4	high_impact	0.24	0.8	28.19	7.1	0.71	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13601	13601	A	C	MI.21959	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1265	422	Y	S	tAt/tCt	7.27	1	0	probably_damaging	1	neutral	0.45	deleterious	-1.82	deleterious	-10.03	deleterious	-8.09	high_impact	3.94	0.34	damaging	0.53	neutral	3.89	23.50	deleterious	0.21	0.45	0.85	disease	0.84	disease	0.72	disease	0.79	disease	6	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.18	medium_impact	2.4	high_impact	0.26	0.8	28.19	7.1	0.72	P	0.97	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6057	6057	C	G	MI.2196	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	154	52	H	D	Cac/Gac	-2.42	0	0	benign	0.2	deleterious	0	neutral	3	neutral	2.49	neutral	-0.72	low_impact	1.73	0.53	damaging	0.49	neutral	3.72	23.30	deleterious	0.26	0.55	0.14	neutral	0.83	disease	0.71	disease	0.79	disease	6	1	deleterious	0.4	neutral	-2	neutral	0.35	neutral	-0.19	medium_impact	-1.48	low_impact	0.5	medium_impact	0.62	0.9	13.84	68.8	0.38	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13603	13603	A	C	MI.21960	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1267	423	S	R	Agc/Cgc	-4.19	0	0	probably_damaging	0.96	neutral	0.35	neutral	-0.42	deleterious	-7.59	deleterious	-4.49	high_impact	3.88	0.58	damaging	0.45	neutral	3.82	23.40	deleterious	0.09	0.35	0.89	disease	0.8	disease	0.77	disease	0.83	disease	7	0.96	neutral	0.2	neutral	2	deleterious	0.84	deleterious	-2.06	low_impact	0.08	medium_impact	2.34	high_impact	0.73	0.85	23.05	6.96	0.41	N	0.99	disease_causing	0.99	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13603	13603	A	G	MI.21961	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1267	423	S	G	Agc/Ggc	-4.19	0	0	possibly_damaging	0.73	neutral	0.33	neutral	-0.39	deleterious	-5.91	deleterious	-3.59	high_impact	3.52	0.56	damaging	0.58	neutral	3.48	23.10	deleterious	0.25	0.45	0.86	disease	0.64	disease	0.68	disease	0.72	disease	4	0.77	neutral	0.3	neutral	1	deleterious	0.76	deleterious	-1.16	low_impact	0.06	medium_impact	2.01	high_impact	0.71	0.85	23.05	6.96	0.37	N	0.86	disease_causing	0.93	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13603	13603	A	T	MI.21962	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1267	423	S	C	Agc/Tgc	-4.19	0	0	probably_damaging	0.99	neutral	0.18	neutral	-0.39	deleterious	-5.8	deleterious	-4.49	high_impact	3.88	0.58	damaging	0.45	neutral	3.38	23.00	deleterious	0.14	0.4	0.91	disease	0.7	disease	0.66	disease	0.79	disease	6	0.99	deleterious	0.1	neutral	2	deleterious	0.80	deleterious	-2.64	low_impact	-0.13	medium_impact	2.34	high_impact	0.61	0.8	23.05	6.96	0.35	N	0.99	disease_causing	0.98	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13604	13604	G	C	MI.21963	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1268	423	S	T	aGc/aCc	8.42	1	0	benign	0.26	neutral	0.39	neutral	-0.24	deleterious	-3.56	deleterious	-2.69	medium_impact	2.35	0.61	neutral	0.66	neutral	3.48	23.10	deleterious	0.29	0.45	0.62	disease	0.41	neutral	0.61	disease	0.56	disease	1	0.53	neutral	0.57	deleterious	-3	neutral	0.74	deleterious	-0.32	medium_impact	0.13	medium_impact	0.94	medium_impact	0.78	0.85	23.05	6.96	0.6	P	0.71	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13604	13604	G	T	MI.21964	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1268	423	S	I	aGc/aTc	8.42	1	0	probably_damaging	0.94	neutral	0.4	neutral	-0.42	deleterious	-7.51	deleterious	-5.39	high_impact	3.88	0.57	damaging	0.56	neutral	4.22	23.90	deleterious	0.16	0.45	0.68	disease	0.82	disease	0.68	disease	0.7	disease	4	0.94	neutral	0.23	neutral	2	deleterious	0.78	deleterious	-1.88	low_impact	0.14	medium_impact	2.34	high_impact	0.77	0.85	23.05	6.96	0.53	P	0.99	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13604	13604	G	A	MI.21965	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1268	423	S	N	aGc/aAc	8.42	1	0	benign	0.17	neutral	0.31	neutral	-0.42	deleterious	-7.02	deleterious	-2.68	medium_impact	3.33	0.55	damaging	0.52	neutral	3.68	23.30	deleterious	0.4	0.5	0.91	disease	0.64	disease	0.61	disease	0.68	disease	4	0.63	neutral	0.57	deleterious	-3	neutral	0.80	deleterious	-0.09	medium_impact	0.04	medium_impact	1.84	medium_impact	0.49	0.8	23.05	6.96	0.59	P	0.87	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13606	13606	A	C	MI.21966	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1270	424	T	P	Act/Cct	-0.75	0	0	possibly_damaging	0.86	neutral	0.18	neutral	0.9	deleterious	-3.84	deleterious	-4.41	medium_impact	2.58	0.64	neutral	0.39	neutral	3.56	23.10	deleterious	0.14	0.4	0.88	disease	0.79	disease	0.66	disease	0.8	disease	6	0.92	neutral	0.16	neutral	0	NA	0.87	deleterious	-1.5	low_impact	-0.13	medium_impact	1.15	medium_impact	0.51	0.8	27.53	18.29	0.28	N	0.91	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13606	13606	A	T	MI.21967	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1270	424	T	S	Act/Tct	-0.75	0	0	possibly_damaging	0.45	neutral	0.53	neutral	0.94	neutral	-1.23	deleterious	-2.61	low_impact	1.77	0.86	neutral	0.65	neutral	3.38	23.00	deleterious	0.41	0.5	0.69	disease	0.38	neutral	0.52	disease	0.64	disease	3	0.45	neutral	0.54	deleterious	-3	neutral	0.74	deleterious	-0.66	medium_impact	0.26	medium_impact	0.41	medium_impact	0.70	0.85	27.53	18.29	0.26	N	0.23	polymorphism	1	0.07	.	.	.	.	.	.	COSM6716786	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13606	13606	A	G	MI.21968	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1270	424	T	A	Act/Gct	-0.75	0	0	benign	0.07	neutral	0.5	neutral	0.99	neutral	-0.04	deleterious	-3.34	medium_impact	2.23	0.84	neutral	0.77	neutral	2.37	18.59	deleterious	0.52	0.6	0.47	neutral	0.28	neutral	0.55	disease	0.49	neutral	0	0.44	neutral	0.72	deleterious	-3	neutral	0.69	deleterious	0.32	medium_impact	0.23	medium_impact	0.83	medium_impact	0.42	0.8	27.53	18.29	0.35	N	0.49	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13607	13607	C	G	MI.21969	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1271	424	T	S	aCt/aGt	-0.06	0	0	possibly_damaging	0.45	neutral	0.53	neutral	0.94	neutral	-1.23	deleterious	-2.61	low_impact	1.77	0.86	neutral	0.65	neutral	3.56	23.10	deleterious	0.41	0.5	0.69	disease	0.38	neutral	0.52	disease	0.64	disease	3	0.45	neutral	0.54	deleterious	-3	neutral	0.74	deleterious	-0.66	medium_impact	0.26	medium_impact	0.41	medium_impact	0.70	0.85	27.53	18.29	0.26	N	0.23	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6057	6057	C	A	MI.2197	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	154	52	H	N	Cac/Aac	-2.42	0	0	benign	0.2	deleterious	0	neutral	2.96	neutral	1.31	neutral	-0.55	low_impact	1.21	0.6	neutral	0.63	neutral	3.86	23.50	deleterious	0.55	0.6	0.18	neutral	0.81	disease	0.53	disease	0.71	disease	4	1	deleterious	0.4	neutral	-2	neutral	0.34	neutral	-0.19	medium_impact	-1.48	low_impact	0.02	medium_impact	0.58	0.9	13.84	68.8	0.37	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13607	13607	C	A	MI.21970	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1271	424	T	N	aCt/aAt	-0.06	0	0	possibly_damaging	0.82	neutral	0.27	neutral	0.9	deleterious	-3.42	deleterious	-3.65	medium_impact	2.58	0.72	neutral	0.52	neutral	3.65	23.20	deleterious	0.36	0.5	0.86	disease	0.59	disease	0.56	disease	0.7	disease	4	0.86	neutral	0.23	neutral	0	NA	0.80	deleterious	-1.37	low_impact	-0.01	medium_impact	1.15	medium_impact	0.70	0.85	27.53	18.29	0.32	N	0.68	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13607	13607	C	T	MI.21971	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1271	424	T	I	aCt/aTt	-0.06	0	0	benign	0.07	neutral	0.51	neutral	1.01	neutral	-0.51	deleterious	-3.79	low_impact	0.82	0.69	neutral	0.69	neutral	2.34	18.44	deleterious	0.35	0.5	0.42	neutral	0.43	neutral	0.38	neutral	0.47	neutral	1	0.43	neutral	0.72	deleterious	-6	neutral	0.69	deleterious	0.32	medium_impact	0.24	medium_impact	-0.45	medium_impact	0.54	0.8	27.53	18.29	0.35	N	0.39	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13609	13609	C	G	MI.21972	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1273	425	R	G	Cga/Gga	-7.62	0	0	probably_damaging	1	neutral	0.41	deleterious	-2.06	deleterious	-9.94	deleterious	-6.29	high_impact	3.92	0.5	damaging	0.09	damaging	4.34	24.00	deleterious	0.24	0.45	0.9	disease	0.74	disease	0.79	disease	0.83	disease	7	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.15	medium_impact	2.38	high_impact	0.27	0.8	29.19	7.21	0.34	N	0.97	polymorphism	0.96	0.43	rs28439808	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13609	13609	C	T	MI.21973	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1273	425	R	W	Cga/Tga	-7.62	0	0	probably_damaging	1	neutral	0.17	deleterious	-2.07	deleterious	-12.5	deleterious	-7.19	high_impact	3.92	0.61	neutral	0.05	damaging	5.31	25.80	deleterious	0.28	0.45	0.86	disease	0.83	disease	0.8	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.15	medium_impact	2.38	high_impact	0.55	0.8	29.19	7.21	0.33	N	1.00	polymorphism	0.88	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13610	13610	G	A	MI.21974	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1274	425	R	Q	cGa/cAa	3.38	0.99	0	probably_damaging	1	neutral	0.25	deleterious	-2.05	deleterious	-9.49	deleterious	-3.59	medium_impact	2.82	0.41	damaging	0.09	damaging	4.61	24.40	deleterious	0.38	0.5	0.82	disease	0.75	disease	0.8	disease	0.72	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.03	medium_impact	1.37	medium_impact	0.61	0.8	29.19	7.21	0.68	P	0.99	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13610	13610	G	C	MI.21975	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1274	425	R	P	cGa/cCa	3.38	0.99	0	probably_damaging	1	neutral	0.23	deleterious	-2.06	deleterious	-10.71	deleterious	-6.29	high_impact	3.92	0.53	damaging	0.07	damaging	4.28	24.00	deleterious	0.19	0.45	0.9	disease	0.83	disease	0.85	disease	0.84	disease	7	1	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.06	medium_impact	2.38	high_impact	0.26	0.8	29.19	7.21	0.46	N	0.99	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13610	13610	G	T	MI.21976	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1274	425	R	L	cGa/cTa	3.38	0.99	0	probably_damaging	1	neutral	0.98	deleterious	-2.06	deleterious	-10.19	deleterious	-6.29	high_impact	3.92	0.5	damaging	0.06	damaging	4.39	24.10	deleterious	0.23	0.45	0.79	disease	0.87	disease	0.77	disease	0.82	disease	6	1	deleterious	0.49	deleterious	2	deleterious	0.84	deleterious	-3.6	low_impact	1.17	medium_impact	2.38	high_impact	0.33	0.8	29.19	7.21	0.53	P	1.00	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13612	13612	A	G	MI.21977	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1276	426	M	V	Ata/Gta	-0.52	0.17	0	benign	0.01	neutral	0.55	neutral	0.98	neutral	-0.19	neutral	1.27	low_impact	0.82	0.82	neutral	0.82	neutral	-0.64	0.10	neutral	0.56	0.6	0.34	neutral	0.16	neutral	0.45	neutral	0.3	neutral	4	0.44	neutral	0.77	deleterious	-6	neutral	0.15	neutral	1.15	medium_impact	0.28	medium_impact	-0.45	medium_impact	0.67	0.85	18.57	19.09	0.29	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13612	13612	A	C	MI.21978	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1276	426	M	L	Ata/Cta	-0.52	0.17	0	benign	0	neutral	0.7	neutral	1.61	neutral	2.75	neutral	0.57	neutral_impact	0.18	0.77	neutral	0.83	neutral	0.26	5.27	deleterious	0.42	0.5	0.38	neutral	0.2	neutral	0.42	neutral	0.37	neutral	3	0.29	neutral	0.85	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.44	medium_impact	-1.04	low_impact	0.65	0.8	18.57	19.09	0.34	N	0.40	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13612	13612	A	T	MI.21979	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1276	426	M	L	Ata/Tta	-0.52	0.17	0	benign	0	neutral	0.7	neutral	1.61	neutral	2.75	neutral	0.57	neutral_impact	0.18	0.77	neutral	0.83	neutral	0.36	6.30	deleterious	0.42	0.5	0.38	neutral	0.2	neutral	0.42	neutral	0.37	neutral	3	0.29	neutral	0.85	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.44	medium_impact	-1.04	low_impact	0.65	0.8	18.57	19.09	0.34	N	0.40	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6057	6057	C	T	MI.2198	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	154	52	H	Y	Cac/Tac	-2.42	0	0	possibly_damaging	0.53	deleterious	0.03	neutral	2.98	neutral	-0.85	neutral	-1.03	medium_impact	2.74	0.6	neutral	0.62	neutral	3.57	23.20	deleterious	0.57	0.6	0.38	neutral	0.81	disease	0.68	disease	0.78	disease	6	0.97	neutral	0.25	neutral	4	deleterious	0.58	deleterious	-0.81	medium_impact	-0.65	medium_impact	1.43	medium_impact	0.43	0.9	13.84	68.8	0.38	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13613	13613	T	C	MI.21980	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1277	426	M	T	aTa/aCa	1.31	0.82	0	benign	0	neutral	0.39	neutral	0.89	neutral	-2.24	neutral	-2.11	low_impact	1.66	0.86	neutral	0.78	neutral	0.35	6.17	deleterious	0.32	0.5	0.7	disease	0.36	neutral	0.63	disease	0.66	disease	3	0.61	neutral	0.7	deleterious	-6	neutral	0.42	neutral	2.1	high_impact	0.13	medium_impact	0.31	medium_impact	0.48	0.8	18.57	19.09	0.32	N	0.13	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13613	13613	T	A	MI.21981	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1277	426	M	K	aTa/aAa	1.31	0.82	0	benign	0.23	neutral	0.29	neutral	0.87	deleterious	-3.63	deleterious	-3.74	medium_impact	2.7	0.72	neutral	0.46	neutral	2.60	20.20	deleterious	0.16	0.45	0.84	disease	0.59	disease	0.71	disease	0.75	disease	5	0.65	neutral	0.53	deleterious	-3	neutral	0.56	deleterious	-0.25	medium_impact	0.02	medium_impact	1.26	medium_impact	0.50	0.8	18.57	19.09	0.32	N	0.88	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13614	13614	A	T	MI.21982	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1278	426	M	I	atA/atT	5.67	0.97	0	benign	0.01	neutral	0.5	neutral	1.2	neutral	1.38	neutral	2.06	neutral_impact	-0.36	0.8	neutral	0.97	neutral	-1.00	0.02	neutral	0.47	0.55	0.34	neutral	0.09	neutral	0.34	neutral	0.21	neutral	6	0.49	neutral	0.75	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.23	medium_impact	-1.53	low_impact	0.71	0.85	18.57	19.09	0.55	P	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13614	13614	A	C	MI.21983	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1278	426	M	I	atA/atC	5.67	0.97	0	benign	0.01	neutral	0.5	neutral	1.2	neutral	1.38	neutral	2.06	neutral_impact	-0.36	0.8	neutral	0.97	neutral	-1.06	0.01	neutral	0.47	0.55	0.34	neutral	0.09	neutral	0.34	neutral	0.21	neutral	6	0.49	neutral	0.75	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.23	medium_impact	-1.53	low_impact	0.71	0.85	18.57	19.09	0.55	P	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13615	13615	A	C	MI.21984	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1279	427	I	L	Att/Ctt	-9	0	0	benign	0.29	neutral	1	neutral	0.82	neutral	-0.42	neutral	-1.57	low_impact	1.91	0.81	neutral	0.92	neutral	2.02	16.34	deleterious	0.25	0.45	0.42	neutral	0.47	neutral	0.36	neutral	0.47	neutral	1	0.29	neutral	0.86	deleterious	-6	neutral	0.22	neutral	-0.38	medium_impact	1.89	high_impact	0.54	medium_impact	0.68	0.85	7.79	15.96	0.24	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13615	13615	A	G	MI.21985	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1279	427	I	V	Att/Gtt	-9	0	0	benign	0.05	neutral	0.8	neutral	0.91	neutral	-0.22	neutral	-0.65	low_impact	1.42	0.82	neutral	0.97	neutral	-0.30	0.67	neutral	0.52	0.6	0.47	neutral	0.1	neutral	0.36	neutral	0.3	neutral	4	0.12	neutral	0.88	deleterious	-6	neutral	0.11	neutral	0.47	medium_impact	0.57	medium_impact	0.09	medium_impact	0.58	0.8	7.79	15.96	0.32	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13615	13615	A	T	MI.21986	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1279	427	I	F	Att/Ttt	-9	0	0	possibly_damaging	0.88	neutral	0.78	neutral	0.73	neutral	-1.44	deleterious	-3.43	medium_impact	2.6	0.72	neutral	0.53	neutral	3.71	23.30	deleterious	0.35	0.5	0.51	disease	0.63	disease	0.54	disease	0.56	disease	1	0.85	neutral	0.45	neutral	0	NA	0.66	deleterious	-1.57	low_impact	0.54	medium_impact	1.17	medium_impact	0.77	0.85	7.79	15.96	0.21	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13616	13616	T	G	MI.21987	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1280	427	I	S	aTt/aGt	0.63	0.02	0	possibly_damaging	0.86	neutral	0.54	neutral	0.81	deleterious	-3.5	deleterious	-5.09	medium_impact	3.15	0.73	neutral	0.52	neutral	4.24	23.90	deleterious	0.26	0.45	0.8	disease	0.76	disease	0.59	disease	0.7	disease	4	0.84	neutral	0.34	neutral	0	NA	0.72	deleterious	-1.5	low_impact	0.27	medium_impact	1.67	medium_impact	0.50	0.8	7.79	15.96	0.27	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13616	13616	T	A	MI.21988	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1280	427	I	N	aTt/aAt	0.63	0.02	0	probably_damaging	0.96	neutral	0.25	neutral	0.68	deleterious	-4.86	deleterious	-5.99	medium_impact	3.5	0.69	neutral	0.39	neutral	4.60	24.40	deleterious	0.2	0.45	0.84	disease	0.77	disease	0.61	disease	0.74	disease	5	0.97	neutral	0.15	neutral	1	deleterious	0.80	deleterious	-2.06	low_impact	-0.03	medium_impact	1.99	medium_impact	0.58	0.8	7.79	15.96	0.33	N	0.97	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13616	13616	T	C	MI.21989	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1280	427	I	T	aTt/aCt	0.63	0.02	0	possibly_damaging	0.76	neutral	0.45	neutral	0.8	neutral	-2.87	deleterious	-4.12	low_impact	1.88	0.72	neutral	0.79	neutral	3.08	22.50	deleterious	0.33	0.5	0.63	disease	0.35	neutral	0.43	neutral	0.61	disease	2	0.75	neutral	0.35	neutral	-3	neutral	0.55	deleterious	-1.22	low_impact	0.18	medium_impact	0.51	medium_impact	0.64	0.8	7.79	15.96	0.4	N	0.95	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6058	6058	A	T	MI.2199	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	155	52	H	L	cAc/cTc	5.68	1	0	benign	0.3	deleterious	0	neutral	3.14	neutral	0.25	neutral	-1.97	medium_impact	2.11	0.62	neutral	0.57	neutral	3.77	23.40	deleterious	0.29	0.55	0.16	neutral	0.84	disease	0.68	disease	0.8	disease	6	1	deleterious	0.35	neutral	1	deleterious	0.43	neutral	-0.41	medium_impact	-1.48	low_impact	0.85	medium_impact	0.37	0.9	13.84	68.8	0.49	P	0.52	disease_causing	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13617	13617	T	A	MI.21990	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1281	427	I	M	atT/atA	2.92	0.13	0.12	benign	0.4	neutral	0.65	neutral	0.73	neutral	-2.3	neutral	-2.27	low_impact	1.6	0.84	neutral	0.97	neutral	2.65	20.50	deleterious	0.37	0.5	0.71	disease	0.4	neutral	0.39	neutral	0.64	disease	3	0.33	neutral	0.63	deleterious	-6	neutral	0.68	deleterious	-0.58	medium_impact	0.38	medium_impact	0.26	medium_impact	0.80	0.85	7.79	15.96	0.35	N	0.26	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13617	13617	T	G	MI.21991	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1281	427	I	M	atT/atG	2.92	0.13	0.12	benign	0.4	neutral	0.65	neutral	0.73	neutral	-2.3	neutral	-2.27	low_impact	1.6	0.84	neutral	0.97	neutral	2.33	18.38	deleterious	0.37	0.5	0.71	disease	0.4	neutral	0.39	neutral	0.64	disease	3	0.33	neutral	0.63	deleterious	-6	neutral	0.68	deleterious	-0.58	medium_impact	0.38	medium_impact	0.26	medium_impact	0.80	0.85	7.79	15.96	0.35	N	0.26	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13618	13618	C	A	MI.21992	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1282	428	L	I	Ctt/Att	-5.1	0	0	benign	0.05	neutral	0.41	neutral	0.91	neutral	-0.86	neutral	-0.06	neutral_impact	-0.03	0.79	neutral	0.81	neutral	3.15	22.60	deleterious	0.44	0.55	0.57	disease	0.32	neutral	0.27	neutral	0.6	disease	2	0.55	neutral	0.68	deleterious	-6	neutral	0.71	deleterious	0.47	medium_impact	0.15	medium_impact	-1.23	low_impact	0.56	0.8	27.53	21.18	0.32	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13618	13618	C	G	MI.21993	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1282	428	L	V	Ctt/Gtt	-5.1	0	0	benign	0.41	neutral	0.46	neutral	0.91	neutral	-0.8	neutral	-0.91	neutral_impact	0.68	0.75	neutral	0.78	neutral	3.53	23.10	deleterious	0.46	0.55	0.5	disease	0.42	neutral	0.51	disease	0.22	neutral	6	0.48	neutral	0.53	deleterious	-6	neutral	0.71	deleterious	-0.6	medium_impact	0.19	medium_impact	-0.58	medium_impact	0.68	0.85	27.53	21.18	0.33	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13618	13618	C	T	MI.21994	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1282	428	L	F	Ctt/Ttt	-5.1	0	0	benign	0.05	neutral	0.74	neutral	1.01	neutral	0.05	neutral	4.89	neutral_impact	-1.28	0.82	neutral	0.97	neutral	1.33	12.42	neutral	0.46	0.55	0.34	neutral	0.06	neutral	0.21	neutral	0.23	neutral	5	0.18	neutral	0.85	deleterious	-6	neutral	0.65	deleterious	0.47	medium_impact	0.48	medium_impact	-2.37	low_impact	0.54	0.8	27.53	21.18	0.28	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13619	13619	T	A	MI.21995	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1283	428	L	H	cTt/cAt	-0.06	0	0	probably_damaging	0.98	neutral	0.45	neutral	0.8	deleterious	-3.8	neutral	-0.78	low_impact	1.17	0.81	neutral	0.84	neutral	4.04	23.70	deleterious	0.2	0.45	0.85	disease	0.59	disease	0.54	disease	0.68	disease	4	0.98	neutral	0.24	neutral	-2	neutral	0.80	deleterious	-2.35	low_impact	0.18	medium_impact	-0.13	medium_impact	0.52	0.8	27.53	21.18	0.28	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13619	13619	T	C	MI.21996	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1283	428	L	P	cTt/cCt	-0.06	0	0	probably_damaging	0.95	neutral	0.17	neutral	0.8	deleterious	-3.87	deleterious	-3.51	low_impact	1.72	0.59	damaging	0.44	neutral	3.85	23.40	deleterious	0.18	0.45	0.86	disease	0.84	disease	0.67	disease	0.83	disease	7	0.97	neutral	0.11	neutral	-2	neutral	0.89	deleterious	-1.96	low_impact	-0.15	medium_impact	0.37	medium_impact	0.61	0.8	27.53	21.18	0.27	N	0.93	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13619	13619	T	G	MI.21997	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1283	428	L	R	cTt/cGt	-0.06	0	0	probably_damaging	0.93	neutral	0.34	neutral	0.8	deleterious	-3.29	deleterious	-2.61	low_impact	1.72	0.69	neutral	0.51	neutral	4.18	23.80	deleterious	0.2	0.45	0.56	disease	0.83	disease	0.65	disease	0.79	disease	6	0.94	neutral	0.21	neutral	-2	neutral	0.82	deleterious	-1.81	low_impact	0.07	medium_impact	0.37	medium_impact	0.68	0.85	27.53	21.18	0.27	N	0.74	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13621	13621	C	T	MI.21998	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1285	429	L	F	Ctc/Ttc	-2.81	0	0	benign	0.02	neutral	0.91	neutral	1.01	neutral	0.08	neutral	3.85	neutral_impact	-0.6	0.85	neutral	0.98	neutral	-0.56	0.16	neutral	0.47	0.55	0.6	disease	0.06	neutral	0.27	neutral	0.3	neutral	4	0.05	neutral	0.95	deleterious	-6	neutral	0.15	neutral	0.86	medium_impact	0.79	medium_impact	-1.75	low_impact	0.71	0.85	18.57	19.16	0.26	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13621	13621	C	A	MI.21999	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1285	429	L	I	Ctc/Atc	-2.81	0	0	benign	0.36	neutral	0.46	neutral	0.88	neutral	-1.28	neutral	-0.23	medium_impact	2.24	0.74	neutral	0.67	neutral	2.49	19.42	deleterious	0.44	0.55	0.63	disease	0.45	neutral	0.56	disease	0.65	disease	3	0.46	neutral	0.55	deleterious	-3	neutral	0.43	neutral	-0.51	medium_impact	0.19	medium_impact	0.84	medium_impact	0.70	0.85	18.57	19.16	0.35	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8536	8536	A	C	MI.22	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	10	4	N	H	Aat/Cat	6.84	1	0	possibly_damaging	0.54	deleterious	0	neutral	4.42	neutral	-2.41	deleterious	-3.52	medium_impact	2.85	0.86	neutral	0.29	neutral	3.80	23.40	deleterious	0.66	0.7	0.85	disease	0.39	neutral	0.62	disease	0.68	disease	4	1	deleterious	0.23	neutral	4	deleterious	0.55	deleterious	-0.82	medium_impact	-1.4	low_impact	1.35	medium_impact	0.34	0.9	41.59	7.51	0.63	P	0.81	disease_causing	0.99	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8630	8630	A	C	MI.220	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	104	35	K	T	aAa/aCa	-0.1	0	0	benign	0.28	neutral	0.41	neutral	4.41	neutral	0.3	neutral	-1.15	neutral_impact	-1.4	0.86	neutral	0.95	neutral	0.04	3.02	deleterious	0.44	0.65	0.58	disease	0.21	neutral	0.3	neutral	0.48	neutral	1	0.5	neutral	0.57	deleterious	-6	neutral	0.45	deleterious	-0.37	medium_impact	0.2	medium_impact	-2.3	low_impact	0.42	0.9	20.35	18.29	0.34	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6058	6058	A	C	MI.2200	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	155	52	H	P	cAc/cCc	5.68	1	0	possibly_damaging	0.66	deleterious	0	neutral	2.96	neutral	-0.22	neutral	-1.35	medium_impact	2.54	0.49	damaging	0.39	neutral	3.08	22.50	deleterious	0.21	0.55	0.3	neutral	0.93	disease	0.78	disease	0.83	disease	7	1	deleterious	0.17	neutral	4	deleterious	0.63	deleterious	-1.03	low_impact	-1.48	low_impact	1.25	medium_impact	0.43	0.9	13.84	68.8	0.54	P	0.59	disease_causing	0.96	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13621	13621	C	G	MI.22000	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1285	429	L	V	Ctc/Gtc	-2.81	0	0	benign	0.25	neutral	0.61	neutral	0.9	neutral	-0.99	neutral	-0.95	medium_impact	2.24	0.72	neutral	0.67	neutral	1.82	15.10	deleterious	0.45	0.55	0.71	disease	0.5	disease	0.58	disease	0.68	disease	4	0.28	neutral	0.68	deleterious	-3	neutral	0.38	neutral	-0.29	medium_impact	0.34	medium_impact	0.84	medium_impact	0.70	0.85	18.57	19.16	0.26	N	0.24	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13622	13622	T	G	MI.22001	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1286	429	L	R	cTc/cGc	0.63	0	0	possibly_damaging	0.6	neutral	0.28	neutral	0.82	neutral	-2.71	deleterious	-2.65	medium_impact	2.24	0.66	neutral	0.58	neutral	3.90	23.50	deleterious	0.21	0.45	0.49	neutral	0.85	disease	0.71	disease	0.79	disease	6	0.73	neutral	0.34	neutral	0	NA	0.67	deleterious	-0.91	medium_impact	0.01	medium_impact	0.84	medium_impact	0.66	0.8	18.57	19.16	0.32	N	0.44	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13622	13622	T	A	MI.22002	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1286	429	L	H	cTc/cAc	0.63	0	0	benign	0.02	neutral	0.4	neutral	0.81	deleterious	-3.19	neutral	-0.81	low_impact	1.78	0.78	neutral	0.81	neutral	2.18	17.37	deleterious	0.23	0.45	0.83	disease	0.69	disease	0.61	disease	0.72	disease	4	0.59	neutral	0.69	deleterious	-6	neutral	0.28	neutral	0.86	medium_impact	0.14	medium_impact	0.42	medium_impact	0.61	0.8	18.57	19.16	0.28	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13622	13622	T	C	MI.22003	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1286	429	L	P	cTc/cCc	0.63	0	0	possibly_damaging	0.89	neutral	0.17	neutral	0.8	deleterious	-3.79	deleterious	-3.56	medium_impact	2.58	0.55	damaging	0.42	neutral	3.93	23.50	deleterious	0.18	0.45	0.89	disease	0.86	disease	0.72	disease	0.82	disease	6	0.94	neutral	0.14	neutral	0	NA	0.86	deleterious	-1.61	low_impact	-0.15	medium_impact	1.15	medium_impact	0.59	0.8	18.57	19.16	0.28	N	0.83	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13624	13624	A	G	MI.22004	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1288	430	T	A	Acc/Gcc	-5.33	0	0	benign	0.08	neutral	0.4	neutral	0.99	neutral	-1.19	neutral	0.6	neutral_impact	0.16	0.79	neutral	1	neutral	1.16	11.53	neutral	0.57	0.65	0.39	neutral	0.2	neutral	0.28	neutral	0.37	neutral	3	0.55	neutral	0.66	deleterious	-6	neutral	0.66	deleterious	0.26	medium_impact	0.14	medium_impact	-1.06	low_impact	0.52	0.8	17.08	11.57	0.38	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13624	13624	A	T	MI.22005	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1288	430	T	S	Acc/Tcc	-5.33	0	0	possibly_damaging	0.73	neutral	0.35	neutral	1.05	neutral	-2.48	neutral	-0.81	low_impact	1.34	0.79	neutral	0.83	neutral	2.28	18.01	deleterious	0.52	0.6	0.69	disease	0.33	neutral	0.26	neutral	0.62	disease	2	0.76	neutral	0.31	neutral	-3	neutral	0.72	deleterious	-1.16	low_impact	0.08	medium_impact	0.02	medium_impact	0.89	0.9	17.08	11.57	0.39	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13624	13624	A	C	MI.22006	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1288	430	T	P	Acc/Ccc	-5.33	0	0	probably_damaging	0.96	neutral	0.13	neutral	0.89	deleterious	-4.16	neutral	-1.91	medium_impact	2.72	0.73	neutral	0.48	neutral	3.58	23.20	deleterious	0.17	0.45	0.84	disease	0.83	disease	0.72	disease	0.81	disease	6	0.98	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-2.06	low_impact	-0.22	medium_impact	1.28	medium_impact	0.70	0.85	17.08	11.57	0.29	N	0.85	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13625	13625	C	G	MI.22007	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1289	430	T	S	aCc/aGc	0.63	0	0	possibly_damaging	0.73	neutral	0.35	neutral	1.05	neutral	-2.48	neutral	-0.81	low_impact	1.34	0.79	neutral	0.83	neutral	2.52	19.59	deleterious	0.52	0.6	0.69	disease	0.33	neutral	0.26	neutral	0.62	disease	2	0.76	neutral	0.31	neutral	-3	neutral	0.72	deleterious	-1.16	low_impact	0.08	medium_impact	0.02	medium_impact	0.89	0.9	17.08	11.57	0.4	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13625	13625	C	A	MI.22008	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1289	430	T	N	aCc/aAc	0.63	0	0	probably_damaging	0.95	neutral	0.19	neutral	0.89	deleterious	-3.33	deleterious	-2.57	medium_impact	2.72	0.73	neutral	0.6	neutral	3.81	23.40	deleterious	0.36	0.5	0.88	disease	0.7	disease	0.56	disease	0.75	disease	5	0.97	neutral	0.12	neutral	1	deleterious	0.81	deleterious	-1.96	low_impact	-0.12	medium_impact	1.28	medium_impact	0.83	0.9	17.08	11.57	0.3	N	0.67	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13625	13625	C	T	MI.22009	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1289	430	T	I	aCc/aTc	0.63	0	0	benign	0.16	neutral	0.34	neutral	1	neutral	-1.38	neutral	-1.18	low_impact	1.4	0.73	neutral	0.73	neutral	3.04	22.40	deleterious	0.37	0.5	0.42	neutral	0.56	disease	0.46	neutral	0.49	neutral	0	0.6	neutral	0.59	deleterious	-6	neutral	0.70	deleterious	-0.06	medium_impact	0.07	medium_impact	0.08	medium_impact	0.73	0.85	17.08	11.57	0.42	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6058	6058	A	G	MI.2201	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	155	52	H	R	cAc/cGc	5.68	1	0	benign	0.2	deleterious	0	neutral	2.99	neutral	0.95	neutral	-0.1	medium_impact	3.08	0.56	damaging	0.5	neutral	2.88	21.80	deleterious	0.6	0.65	0.24	neutral	0.86	disease	0.67	disease	0.81	disease	6	1	deleterious	0.4	neutral	1	deleterious	0.39	neutral	-0.19	medium_impact	-1.48	low_impact	1.75	medium_impact	0.43	0.9	13.84	68.8	0.51	P	0.24	disease_causing	0.86	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13627	13627	C	A	MI.22010	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1291	431	L	M	Cta/Ata	-7.17	0	0	possibly_damaging	0.66	neutral	0.26	neutral	0.97	neutral	-1.06	neutral	-1.37	low_impact	1.45	0.83	neutral	0.76	neutral	2.79	21.30	deleterious	0.33	0.5	0.52	disease	0.25	neutral	0.21	neutral	0.37	neutral	3	0.78	neutral	0.3	neutral	-3	neutral	0.69	deleterious	-1.02	low_impact	-0.02	medium_impact	0.12	medium_impact	0.84	0.9	10.61	12.66	0.42	N	0.17	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13627	13627	C	G	MI.22011	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1291	431	L	V	Cta/Gta	-7.17	0	0	possibly_damaging	0.9	neutral	0.57	neutral	0.95	neutral	-0.63	neutral	-2.15	low_impact	1.57	0.84	neutral	0.9	neutral	2.32	18.28	deleterious	0.33	0.5	0.44	neutral	0.3	neutral	0.19	neutral	0.47	neutral	1	0.88	neutral	0.34	neutral	-3	neutral	0.69	deleterious	-1.65	low_impact	0.3	medium_impact	0.23	medium_impact	0.70	0.85	10.61	12.66	0.34	N	0.32	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13628	13628	T	A	MI.22012	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1292	431	L	Q	cTa/cAa	-0.98	0	0	probably_damaging	0.99	neutral	0.31	neutral	0.84	neutral	-2.65	deleterious	-4.89	low_impact	1.19	0.79	neutral	0.79	neutral	4.18	23.80	deleterious	0.22	0.45	0.65	disease	0.29	neutral	0.24	neutral	0.58	disease	2	0.99	deleterious	0.16	neutral	-2	neutral	0.74	deleterious	-2.64	low_impact	0.04	medium_impact	-0.12	medium_impact	0.68	0.85	10.61	12.66	0.38	N	0.86	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13628	13628	T	C	MI.22013	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1292	431	L	P	cTa/cCa	-0.98	0	0	probably_damaging	1	neutral	0.23	neutral	0.78	deleterious	-3.51	deleterious	-5.76	medium_impact	2.56	0.59	damaging	0.5	neutral	4.01	23.60	deleterious	0.2	0.45	0.88	disease	0.79	disease	0.59	disease	0.77	disease	5	1	deleterious	0.12	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	-0.06	medium_impact	1.14	medium_impact	0.61	0.8	10.61	12.66	0.28	N	0.95	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13628	13628	T	G	MI.22014	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1292	431	L	R	cTa/cGa	-0.98	0	0	probably_damaging	0.98	neutral	0.43	neutral	0.79	deleterious	-3.01	deleterious	-4.98	medium_impact	3.12	0.72	neutral	0.45	neutral	4.26	23.90	deleterious	0.18	0.45	0.84	disease	0.75	disease	0.55	disease	0.73	disease	5	0.98	deleterious	0.23	neutral	1	deleterious	0.85	deleterious	-2.35	low_impact	0.17	medium_impact	1.65	medium_impact	0.51	0.8	10.61	12.66	0.28	N	0.93	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13630	13630	A	C	MI.22015	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1294	432	T	P	Aca/Cca	-5.56	0	0.01	probably_damaging	0.92	neutral	0.23	neutral	0.83	neutral	-2.56	neutral	-1.82	medium_impact	2.35	0.62	neutral	0.39	neutral	3.56	23.10	deleterious	0.19	0.45	0.83	disease	0.74	disease	0.57	disease	0.75	disease	5	0.94	neutral	0.16	neutral	1	deleterious	0.82	deleterious	-1.75	low_impact	-0.06	medium_impact	0.94	medium_impact	0.44	0.8	25.37	21.71	0.29	N	0.82	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13630	13630	A	T	MI.22016	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1294	432	T	S	Aca/Tca	-5.56	0	0.01	possibly_damaging	0.52	neutral	0.46	neutral	0.96	neutral	-1.16	neutral	-0.86	low_impact	1.66	0.82	neutral	0.78	neutral	2.99	22.20	deleterious	0.52	0.6	0.65	disease	0.3	neutral	0.44	neutral	0.61	disease	2	0.55	neutral	0.47	deleterious	-3	neutral	0.51	deleterious	-0.78	medium_impact	0.19	medium_impact	0.31	medium_impact	0.59	0.8	25.37	21.71	0.34	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13630	13630	A	G	MI.22017	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1294	432	T	A	Aca/Gca	-5.56	0	0.01	benign	0.05	neutral	0.54	neutral	0.9	neutral	-0.93	neutral	-0.3	low_impact	1.54	0.78	neutral	0.82	neutral	1.93	15.76	deleterious	0.65	0.7	0.6	disease	0.25	neutral	0.58	disease	0.58	disease	2	0.4	neutral	0.75	deleterious	-6	neutral	0.41	neutral	0.47	medium_impact	0.27	medium_impact	0.2	medium_impact	0.30	0.8	25.37	21.71	0.3	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13631	13631	C	A	MI.22018	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1295	432	T	K	aCa/aAa	-0.29	0	0	possibly_damaging	0.73	neutral	0.32	neutral	0.84	neutral	-2.15	neutral	-0.92	medium_impact	2.35	0.72	neutral	0.53	neutral	4.25	23.90	deleterious	0.31	0.45	0.83	disease	0.61	disease	0.7	disease	0.76	disease	5	0.78	neutral	0.3	neutral	0	NA	0.66	deleterious	-1.16	low_impact	0.05	medium_impact	0.94	medium_impact	0.61	0.8	25.37	21.71	0.31	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13631	13631	C	T	MI.22019	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1295	432	T	M	aCa/aTa	-0.29	0	0	benign	0.2	neutral	0.3	neutral	0.97	neutral	-1.12	neutral	2.55	neutral_impact	0.2	0.76	neutral	0.91	neutral	-0.47	0.27	neutral	0.42	0.55	0.43	neutral	0.06	neutral	0.18	neutral	0.24	neutral	5	0.64	neutral	0.55	deleterious	-6	neutral	0.19	neutral	-0.17	medium_impact	0.03	medium_impact	-1.02	low_impact	0.61	0.8	25.37	21.71	0.53	N	0.17	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6059	6059	C	G	MI.2202	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	156	52	H	Q	caC/caG	8.69	1	0	benign	0.02	neutral	1	neutral	3.13	neutral	1.57	neutral	2.07	neutral_impact	-1.75	0.71	neutral	0.91	neutral	0.71	8.88	deleterious	0.58	0.65	0.29	neutral	0.12	neutral	0.33	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.14	neutral	0.83	medium_impact	1.86	high_impact	-2.72	low_impact	0.65	0.9	13.84	68.8	0.55	P	0.00	disease_causing	0.66	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13633	13633	G	T	MI.22020	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1297	433	G	C	Ggt/Tgt	-0.52	0	0	probably_damaging	0.99	neutral	0.18	neutral	0.65	deleterious	-7.14	deleterious	-5.68	medium_impact	3.21	0.69	neutral	0.3	neutral	4.26	23.90	deleterious	0.27	0.45	0.97	disease	0.83	disease	0.65	disease	0.84	disease	7	1	deleterious	0.1	neutral	1	deleterious	0.85	deleterious	-2.64	low_impact	-0.13	medium_impact	1.73	medium_impact	0.39	0.8	23.55	15.58	0.27	N	0.76	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13633	13633	G	A	MI.22021	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1297	433	G	S	Ggt/Agt	-0.52	0	0	benign	0.42	neutral	0.43	neutral	0.79	deleterious	-3.53	deleterious	-2.63	medium_impact	2.17	0.81	neutral	0.81	neutral	2.32	18.29	deleterious	0.4	0.5	0.71	disease	0.58	disease	0.39	neutral	0.5	disease	0	0.52	neutral	0.51	deleterious	-3	neutral	0.29	neutral	-0.61	medium_impact	0.17	medium_impact	0.78	medium_impact	0.78	0.85	23.55	15.58	0.3	N	0.08	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13633	13633	G	C	MI.22022	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1297	433	G	R	Ggt/Cgt	-0.52	0	0	probably_damaging	0.97	neutral	0.36	neutral	0.72	deleterious	-3.89	deleterious	-4.46	medium_impact	2.86	0.71	neutral	0.36	neutral	4.00	23.60	deleterious	0.3	0.45	0.74	disease	0.82	disease	0.74	disease	0.77	disease	5	0.97	neutral	0.2	neutral	1	deleterious	0.80	deleterious	-2.18	low_impact	0.1	medium_impact	1.41	medium_impact	0.79	0.85	23.55	15.58	0.27	N	0.81	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13634	13634	G	A	MI.22023	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1298	433	G	D	gGt/gAt	-0.06	0	0	probably_damaging	0.91	neutral	0.23	neutral	0.71	deleterious	-3.7	deleterious	-3.18	medium_impact	2.31	0.81	neutral	0.54	neutral	3.61	23.20	deleterious	0.32	0.5	0.68	disease	0.79	disease	0.76	disease	0.75	disease	5	0.94	neutral	0.16	neutral	1	deleterious	0.66	deleterious	-1.7	low_impact	-0.06	medium_impact	0.91	medium_impact	0.43	0.8	23.55	15.58	0.31	N	0.69	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13634	13634	G	C	MI.22024	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1298	433	G	A	gGt/gCt	-0.06	0	0	possibly_damaging	0.86	neutral	0.53	neutral	0.73	deleterious	-3.2	deleterious	-3.45	medium_impact	2.51	0.77	neutral	0.62	neutral	2.86	21.70	deleterious	0.45	0.55	0.69	disease	0.51	disease	0.51	disease	0.48	neutral	0	0.84	neutral	0.34	neutral	0	NA	0.56	deleterious	-1.5	low_impact	0.26	medium_impact	1.09	medium_impact	0.71	0.85	23.55	15.58	0.25	N	0.42	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13634	13634	G	T	MI.22025	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1298	433	G	V	gGt/gTt	-0.06	0	0	probably_damaging	0.97	neutral	0.52	neutral	0.68	deleterious	-4.57	deleterious	-5.64	medium_impact	2.86	0.74	neutral	0.36	neutral	3.78	23.40	deleterious	0.27	0.45	0.83	disease	0.75	disease	0.67	disease	0.73	disease	5	0.97	neutral	0.28	neutral	1	deleterious	0.79	deleterious	-2.18	low_impact	0.25	medium_impact	1.41	medium_impact	0.43	0.8	23.55	15.58	0.23	N	0.78	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13636	13636	C	G	MI.22026	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1300	434	Q	E	Caa/Gaa	-6.02	0	0	benign	0.18	neutral	0.29	neutral	1.03	neutral	1.16	neutral	-1.89	medium_impact	2.29	0.85	neutral	0.72	neutral	0.20	4.69	deleterious	0.6	0.65	0.3	neutral	0.44	neutral	0.47	neutral	0.46	neutral	1	0.66	neutral	0.56	deleterious	-3	neutral	0.24	neutral	-0.12	medium_impact	0.02	medium_impact	0.89	medium_impact	0.61	0.8	25.54	16.4	0.38	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13636	13636	C	A	MI.22027	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1300	434	Q	K	Caa/Aaa	-6.02	0	0	benign	0.01	neutral	0.31	neutral	1.01	neutral	1.03	neutral	-2.09	low_impact	1.84	0.85	neutral	0.79	neutral	0.74	9.06	deleterious	0.64	0.7	0.29	neutral	0.49	neutral	0.47	neutral	0.46	neutral	1	0.68	neutral	0.65	deleterious	-6	neutral	0.16	neutral	1.15	medium_impact	0.04	medium_impact	0.48	medium_impact	0.51	0.8	25.54	16.4	0.34	N	0.13	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13637	13637	A	G	MI.22028	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1301	434	Q	R	cAa/cGa	-0.98	0	0.02	benign	0.01	neutral	0.36	neutral	0.95	neutral	-0.15	neutral	-2.38	low_impact	1.49	0.82	neutral	0.65	neutral	0.58	8.02	deleterious	0.63	0.7	0.38	neutral	0.51	disease	0.48	neutral	0.47	neutral	1	0.63	neutral	0.68	deleterious	-6	neutral	0.19	neutral	1.15	medium_impact	0.1	medium_impact	0.16	medium_impact	0.44	0.8	25.54	16.4	0.37	N	0.34	disease_causing_automatic	0	0.06	rs200855215	Pathogenic	Leber's_optic_atrophy	76419	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	A13637G	Possible LHON factor	+	-	Reported	2	P	P	P	damaging
chrM	13637	13637	A	C	MI.22029	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1301	434	Q	P	cAa/cCa	-0.98	0	0.02	benign	0.01	neutral	0.23	neutral	0.94	neutral	-0.65	deleterious	-4.14	low_impact	1.49	0.85	neutral	0.59	neutral	2.11	16.93	deleterious	0.24	0.45	0.57	disease	0.76	disease	0.35	neutral	0.57	disease	1	0.77	neutral	0.61	deleterious	-6	neutral	0.65	deleterious	1.15	medium_impact	-0.06	medium_impact	0.16	medium_impact	0.40	0.8	25.54	16.4	0.32	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6059	6059	C	A	MI.2203	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	156	52	H	Q	caC/caA	8.69	1	0	benign	0.02	neutral	1	neutral	3.13	neutral	1.57	neutral	2.07	neutral_impact	-1.75	0.71	neutral	0.91	neutral	1.11	11.27	neutral	0.58	0.65	0.29	neutral	0.12	neutral	0.33	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.14	neutral	0.83	medium_impact	1.86	high_impact	-2.72	low_impact	0.65	0.9	13.84	68.8	0.55	P	0.00	disease_causing	0.66	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13637	13637	A	T	MI.22030	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1301	434	Q	L	cAa/cTa	-0.98	0	0.02	benign	0.18	neutral	0.69	neutral	0.93	neutral	-1.96	deleterious	-4.89	medium_impact	2.09	0.8	neutral	0.57	neutral	2.23	17.72	deleterious	0.42	0.5	0.63	disease	0.53	disease	0.37	neutral	0.51	disease	0	0.19	neutral	0.76	deleterious	-3	neutral	0.42	neutral	-0.12	medium_impact	0.42	medium_impact	0.71	medium_impact	0.32	0.8	25.54	16.4	0.24	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13638	13638	A	C	MI.22031	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1302	434	Q	H	caA/caC	0.17	0	0	benign	0.01	neutral	0.54	neutral	0.96	neutral	-1.9	deleterious	-2.76	neutral_impact	0.47	0.81	neutral	0.8	neutral	2.16	17.22	deleterious	0.59	0.65	0.46	neutral	0.18	neutral	0.23	neutral	0.26	neutral	5	0.44	neutral	0.77	deleterious	-6	neutral	0.63	deleterious	1.15	medium_impact	0.27	medium_impact	-0.77	medium_impact	0.49	0.8	25.54	16.4	0.32	N	0.48	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13638	13638	A	T	MI.22032	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1302	434	Q	H	caA/caT	0.17	0	0	benign	0.01	neutral	0.54	neutral	0.96	neutral	-1.9	deleterious	-2.76	neutral_impact	0.47	0.81	neutral	0.8	neutral	2.32	18.28	deleterious	0.59	0.65	0.46	neutral	0.18	neutral	0.23	neutral	0.26	neutral	5	0.44	neutral	0.77	deleterious	-6	neutral	0.63	deleterious	1.15	medium_impact	0.27	medium_impact	-0.77	medium_impact	0.49	0.8	25.54	16.4	0.32	N	0.48	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13639	13639	C	A	MI.22033	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1303	435	P	T	Cct/Act	-2.35	0	0	probably_damaging	1	neutral	0.41	neutral	0.83	neutral	-2.46	deleterious	-7.19	medium_impact	2.2	0.75	neutral	0.29	neutral	4.00	23.60	deleterious	0.51	0.6	0.67	disease	0.61	disease	0.55	disease	0.49	neutral	0	1	deleterious	0.21	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.15	medium_impact	0.81	medium_impact	0.80	0.85	27.69	7.3	0.25	N	0.91	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13639	13639	C	T	MI.22034	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1303	435	P	S	Cct/Tct	-2.35	0	0	probably_damaging	1	neutral	0.46	neutral	0.82	neutral	-2.42	deleterious	-7.19	medium_impact	3	0.73	neutral	0.15	damaging	4.01	23.60	deleterious	0.58	0.65	0.67	disease	0.69	disease	0.56	disease	0.55	disease	1	1	deleterious	0.23	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.19	medium_impact	1.54	medium_impact	0.35	0.8	27.69	7.3	0.25	N	0.78	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13639	13639	C	G	MI.22035	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1303	435	P	A	Cct/Gct	-2.35	0	0	probably_damaging	1	neutral	0.52	neutral	0.82	neutral	-2.27	deleterious	-7.19	medium_impact	3.26	0.71	neutral	0.2	damaging	3.21	22.70	deleterious	0.51	0.6	0.68	disease	0.55	disease	0.63	disease	0.56	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.25	medium_impact	1.78	medium_impact	0.85	0.9	27.69	7.3	0.26	N	0.73	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13640	13640	C	A	MI.22036	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1304	435	P	H	cCt/cAt	4.29	0.98	0	probably_damaging	1	neutral	0.54	neutral	0.78	deleterious	-4.15	deleterious	-8.09	high_impact	3.81	0.72	neutral	0.11	damaging	4.24	23.90	deleterious	0.53	0.6	0.81	disease	0.82	disease	0.67	disease	0.74	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.27	medium_impact	2.28	high_impact	0.56	0.8	27.69	7.3	0.46	N	0.72	disease_causing	0.89	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13640	13640	C	G	MI.22037	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1304	435	P	R	cCt/cGt	4.29	0.98	0	probably_damaging	1	neutral	0.36	neutral	0.77	neutral	-2.77	deleterious	-8.08	high_impact	3.81	0.69	neutral	0.11	damaging	3.74	23.30	deleterious	0.47	0.55	0.64	disease	0.86	disease	0.7	disease	0.77	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.1	medium_impact	2.28	high_impact	0.68	0.85	27.69	7.3	0.49	N	0.64	disease_causing	0.94	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13640	13640	C	T	MI.22038	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1304	435	P	L	cCt/cTt	4.29	0.98	0	probably_damaging	1	neutral	0.71	neutral	0.88	neutral	-2.83	deleterious	-8.98	medium_impact	3.46	0.7	neutral	0.1	damaging	4.46	24.20	deleterious	0.52	0.6	0.52	disease	0.81	disease	0.6	disease	0.68	disease	4	1	deleterious	0.36	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.45	medium_impact	1.96	medium_impact	0.84	0.9	27.69	7.3	0.41	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13642	13642	C	A	MI.22039	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1306	436	R	S	Cgc/Agc	-11.75	0	0	possibly_damaging	0.82	neutral	0.44	neutral	0.87	neutral	-2.23	deleterious	-4.84	high_impact	3.83	0.69	neutral	0.29	neutral	3.10	22.50	deleterious	0.52	0.6	0.62	disease	0.79	disease	0.71	disease	0.71	disease	4	0.81	neutral	0.31	neutral	1	deleterious	0.55	deleterious	-1.37	low_impact	0.18	medium_impact	2.3	high_impact	0.57	0.8	11.61	7.34	0.32	N	0.81	polymorphism	0.63	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6060	6060	A	G	MI.2204	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	157	53	I	V	Atc/Gtc	-1.72	0	0	benign	0	neutral	0.28	neutral	2.86	neutral	-0.18	neutral	-0.47	medium_impact	2.14	0.7	neutral	0.84	neutral	-0.22	0.98	neutral	0.64	0.65	0.29	neutral	0.43	neutral	0.28	neutral	0.47	neutral	1	0.72	neutral	0.64	deleterious	-3	neutral	0.16	neutral	2.07	high_impact	-0.04	medium_impact	0.88	medium_impact	0.65	0.9	8.97	39.65	0.54	N	0.23	disease_causing	0.86	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13642	13642	C	G	MI.22040	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1306	436	R	G	Cgc/Ggc	-11.75	0	0	possibly_damaging	0.86	neutral	0.35	neutral	0.82	deleterious	-3.43	deleterious	-5.75	high_impact	3.83	0.66	neutral	0.35	neutral	2.79	21.30	deleterious	0.59	0.65	0.82	disease	0.74	disease	0.72	disease	0.75	disease	5	0.87	neutral	0.25	neutral	1	deleterious	0.56	deleterious	-1.5	low_impact	0.08	medium_impact	2.3	high_impact	0.54	0.8	11.61	7.34	0.31	N	0.93	polymorphism	0.64	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13642	13642	C	T	MI.22041	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1306	436	R	C	Cgc/Tgc	-11.75	0	0	probably_damaging	0.98	neutral	0.18	neutral	0.75	deleterious	-6.42	deleterious	-6.71	high_impact	3.83	0.7	neutral	0.18	damaging	5.11	25.30	deleterious	0.41	0.5	0.97	disease	0.85	disease	0.76	disease	0.85	disease	7	0.99	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	-0.13	medium_impact	2.3	high_impact	0.81	0.85	11.61	7.34	0.31	N	1.00	disease_causing	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13643	13643	G	A	MI.22042	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1307	436	R	H	cGc/cAc	2.23	0.95	0	benign	0.11	neutral	0.54	neutral	0.78	deleterious	-3.72	deleterious	-3.51	medium_impact	3.13	0.65	neutral	0.33	neutral	2.56	19.88	deleterious	0.64	0.7	0.88	disease	0.78	disease	0.63	disease	0.7	disease	4	0.37	neutral	0.72	deleterious	-3	neutral	0.31	neutral	0.12	medium_impact	0.27	medium_impact	1.66	medium_impact	0.86	0.9	11.61	7.34	0.38	N	0.43	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13643	13643	G	C	MI.22043	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1307	436	R	P	cGc/cCc	2.23	0.95	0	probably_damaging	0.96	neutral	0.23	neutral	0.77	deleterious	-3.78	deleterious	-5.82	high_impact	3.83	0.71	neutral	0.21	damaging	4.23	23.90	deleterious	0.44	0.55	0.75	disease	0.88	disease	0.71	disease	0.77	disease	5	0.97	neutral	0.14	neutral	2	deleterious	0.81	deleterious	-2.06	low_impact	-0.06	medium_impact	2.3	high_impact	0.54	0.8	11.61	7.34	0.45	N	0.98	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13643	13643	G	T	MI.22044	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1307	436	R	L	cGc/cTc	2.23	0.95	0	benign	0.08	neutral	0.66	neutral	0.79	deleterious	-3.73	deleterious	-5.92	medium_impact	3.02	0.65	neutral	0.31	neutral	2.52	19.60	deleterious	0.56	0.6	0.83	disease	0.89	disease	0.72	disease	0.79	disease	6	0.25	neutral	0.79	deleterious	-3	neutral	0.32	neutral	0.26	medium_impact	0.39	medium_impact	1.56	medium_impact	0.55	0.8	11.61	7.34	0.36	N	0.99	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13645	13645	T	A	MI.22045	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1309	437	F	I	Ttc/Atc	-3.73	0	0	possibly_damaging	0.63	neutral	0.4	neutral	0.9	neutral	-0.88	deleterious	-4.51	medium_impact	1.94	0.79	neutral	0.76	neutral	2.86	21.70	deleterious	0.49	0.55	0.75	disease	0.53	disease	0.39	neutral	0.53	disease	1	0.66	neutral	0.39	neutral	0	NA	0.41	neutral	-0.97	medium_impact	0.14	medium_impact	0.57	medium_impact	0.51	0.8	5.64	8.73	0.31	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13645	13645	T	C	MI.22046	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1309	437	F	L	Ttc/Ctc	-3.73	0	0	benign	0.08	neutral	0.66	neutral	0.97	neutral	-0.2	deleterious	-4.49	medium_impact	2.29	0.8	neutral	0.7	neutral	2.29	18.09	deleterious	0.59	0.65	0.54	disease	0.6	disease	0.4	neutral	0.49	neutral	0	0.25	neutral	0.79	deleterious	-3	neutral	0.18	neutral	0.26	medium_impact	0.39	medium_impact	0.89	medium_impact	0.44	0.8	5.64	8.73	0.24	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13645	13645	T	G	MI.22047	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1309	437	F	V	Ttc/Gtc	-3.73	0	0	possibly_damaging	0.74	neutral	0.51	neutral	0.89	neutral	-1.07	deleterious	-5.13	medium_impact	3.27	0.82	neutral	0.61	neutral	2.64	20.50	deleterious	0.45	0.55	0.73	disease	0.68	disease	0.62	disease	0.65	disease	3	0.72	neutral	0.39	neutral	0	NA	0.45	deleterious	-1.18	low_impact	0.24	medium_impact	1.78	medium_impact	0.34	0.8	5.64	8.73	0.29	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13646	13646	T	C	MI.22048	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1310	437	F	S	tTc/tCc	1.77	0.02	0	probably_damaging	0.96	neutral	0.42	neutral	0.88	neutral	-1.23	deleterious	-5.31	low_impact	1.66	0.86	neutral	0.92	neutral	3.15	22.60	deleterious	0.5	0.6	0.43	neutral	0.65	disease	0.44	neutral	0.5	neutral	0	0.96	neutral	0.23	neutral	-2	neutral	0.64	deleterious	-2.06	low_impact	0.16	medium_impact	0.31	medium_impact	0.28	0.8	5.64	8.73	0.34	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13646	13646	T	A	MI.22049	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1310	437	F	Y	tTc/tAc	1.77	0.02	0	possibly_damaging	0.89	neutral	1	neutral	0.85	neutral	-1.74	neutral	-1.3	low_impact	1.32	0.86	neutral	0.97	neutral	3.01	22.30	deleterious	0.57	0.65	0.68	disease	0.52	disease	0.37	neutral	0.5	disease	0	0.89	neutral	0.56	deleterious	-3	neutral	0.62	deleterious	-1.61	low_impact	1.89	high_impact	0	medium_impact	0.55	0.8	5.64	8.73	0.26	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6060	6060	A	C	MI.2205	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	157	53	I	L	Atc/Ctc	-1.72	0	0	benign	0.07	neutral	0.39	neutral	2.87	neutral	2.54	neutral	-0.61	neutral_impact	0.53	0.66	neutral	0.82	neutral	0.18	4.42	deleterious	0.48	0.55	0.15	neutral	0.25	neutral	0.18	neutral	0.43	neutral	1	0.57	neutral	0.66	deleterious	-6	neutral	0.14	neutral	0.3	medium_impact	0.09	medium_impact	-0.61	medium_impact	0.78	0.9	8.97	39.65	0.55	P	0.61	disease_causing	0.94	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13646	13646	T	G	MI.22050	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1310	437	F	C	tTc/tGc	1.77	0.02	0	probably_damaging	0.98	neutral	0.18	neutral	0.86	neutral	-1.58	deleterious	-5.84	medium_impact	2.71	0.78	neutral	0.45	neutral	4.21	23.90	deleterious	0.48	0.55	0.77	disease	0.82	disease	0.55	disease	0.72	disease	4	0.99	deleterious	0.1	neutral	1	deleterious	0.76	deleterious	-2.35	low_impact	-0.13	medium_impact	1.27	medium_impact	0.28	0.8	5.64	8.73	0.3	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13647	13647	C	G	MI.22051	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1311	437	F	L	ttC/ttG	-1.67	0	0	benign	0.08	neutral	0.66	neutral	0.97	neutral	-0.2	deleterious	-4.49	medium_impact	2.29	0.8	neutral	0.7	neutral	2.60	20.20	deleterious	0.59	0.65	0.54	disease	0.6	disease	0.4	neutral	0.49	neutral	0	0.25	neutral	0.79	deleterious	-3	neutral	0.18	neutral	0.26	medium_impact	0.39	medium_impact	0.89	medium_impact	0.44	0.8	5.64	8.73	0.24	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13647	13647	C	A	MI.22052	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1311	437	F	L	ttC/ttA	-1.67	0	0	benign	0.08	neutral	0.66	neutral	0.97	neutral	-0.2	deleterious	-4.49	medium_impact	2.29	0.8	neutral	0.7	neutral	2.88	21.70	deleterious	0.59	0.65	0.54	disease	0.6	disease	0.4	neutral	0.49	neutral	0	0.25	neutral	0.79	deleterious	-3	neutral	0.18	neutral	0.26	medium_impact	0.39	medium_impact	0.89	medium_impact	0.44	0.8	5.64	8.73	0.24	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13648	13648	C	T	MI.22053	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1312	438	P	S	Ccc/Tcc	-5.79	0	0	benign	0.04	neutral	0.46	neutral	1.1	neutral	-0.57	neutral	-1.53	neutral_impact	-0.16	0.91	neutral	0.99	neutral	2.35	18.51	deleterious	0.59	0.65	0.51	disease	0.14	neutral	0.22	neutral	0.24	neutral	5	0.51	neutral	0.71	deleterious	-6	neutral	0.66	deleterious	0.57	medium_impact	0.19	medium_impact	-1.35	low_impact	0.20	0.8	21.06	13.62	0.41	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13648	13648	C	G	MI.22054	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1312	438	P	A	Ccc/Gcc	-5.79	0	0	possibly_damaging	0.45	neutral	0.51	neutral	1.01	neutral	-0.64	neutral	-2.24	low_impact	1.33	0.84	neutral	0.78	neutral	1.38	12.67	neutral	0.46	0.55	0.46	neutral	0.1	neutral	0.36	neutral	0.3	neutral	4	0.46	neutral	0.53	deleterious	-3	neutral	0.66	deleterious	-0.66	medium_impact	0.24	medium_impact	0.01	medium_impact	0.68	0.85	21.06	13.62	0.33	N	0.72	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13648	13648	C	A	MI.22055	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1312	438	P	T	Ccc/Acc	-5.79	0	0	benign	0.07	neutral	0.41	neutral	0.97	neutral	-1.19	neutral	-1.44	neutral_impact	0.06	0.86	neutral	0.91	neutral	2.16	17.27	deleterious	0.45	0.55	0.57	disease	0.15	neutral	0.23	neutral	0.37	neutral	3	0.54	neutral	0.67	deleterious	-6	neutral	0.66	deleterious	0.32	medium_impact	0.15	medium_impact	-1.15	low_impact	0.65	0.8	21.06	13.62	0.35	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13649	13649	C	G	MI.22056	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1313	438	P	R	cCc/cGc	-2.58	0	0	possibly_damaging	0.82	neutral	0.35	neutral	0.96	neutral	-1.19	deleterious	-2.63	medium_impact	2.13	0.78	neutral	0.59	neutral	2.15	17.19	deleterious	0.5	0.6	0.56	disease	0.33	neutral	0.51	disease	0.59	disease	2	0.84	neutral	0.27	neutral	0	NA	0.71	deleterious	-1.37	low_impact	0.08	medium_impact	0.74	medium_impact	0.55	0.8	21.06	13.62	0.31	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13649	13649	C	A	MI.22057	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1313	438	P	H	cCc/cAc	-2.58	0	0	probably_damaging	0.97	neutral	0.54	neutral	0.93	neutral	-1.78	neutral	-2.24	low_impact	1.24	0.86	neutral	0.86	neutral	2.27	17.95	deleterious	0.5	0.6	0.8	disease	0.26	neutral	0.31	neutral	0.59	disease	2	0.96	neutral	0.29	neutral	-2	neutral	0.71	deleterious	-2.18	low_impact	0.27	medium_impact	-0.07	medium_impact	0.52	0.8	21.06	13.62	0.26	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13649	13649	C	T	MI.22058	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1313	438	P	L	cCc/cTc	-2.58	0	0	benign	0.33	neutral	0.74	neutral	1.04	neutral	-1.87	deleterious	-3.42	neutral_impact	-0.12	0.81	neutral	0.95	neutral	2.42	18.94	deleterious	0.54	0.6	0.69	disease	0.15	neutral	0.26	neutral	0.36	neutral	3	0.23	neutral	0.71	deleterious	-6	neutral	0.69	deleterious	-0.45	medium_impact	0.48	medium_impact	-1.31	low_impact	0.84	0.9	21.06	13.62	0.24	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13651	13651	A	G	MI.22059	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1315	439	T	A	Acc/Gcc	-20	0	0.04	benign	0.08	neutral	0.52	neutral	1	neutral	-0.02	neutral	-1.55	neutral_impact	0.79	0.88	neutral	0.95	neutral	2.92	21.90	deleterious	0.69	0.75	0.46	neutral	0.12	neutral	0.26	neutral	0.31	neutral	4	0.41	neutral	0.72	deleterious	-6	neutral	0.69	deleterious	0.26	medium_impact	0.25	medium_impact	-0.48	medium_impact	0.30	0.8	7.79	12	0.43	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6060	6060	A	T	MI.2206	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	157	53	I	F	Atc/Ttc	-1.72	0	0	possibly_damaging	0.55	neutral	0.11	neutral	2.78	neutral	-1.25	neutral	-1.94	medium_impact	2.08	0.61	neutral	0.39	neutral	1.78	14.86	neutral	0.47	0.55	0.47	neutral	0.77	disease	0.27	neutral	0.5	neutral	0	0.88	neutral	0.28	neutral	0	NA	0.57	deleterious	-0.84	medium_impact	-0.31	medium_impact	0.82	medium_impact	0.81	0.9	8.97	39.65	0.39	N	0.85	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13651	13651	A	C	MI.22060	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1315	439	T	P	Acc/Ccc	-20	0	0.04	probably_damaging	0.95	neutral	0.22	neutral	1.05	neutral	0.51	neutral	0.2	neutral_impact	-1.06	0.83	neutral	0.99	neutral	1.47	13.15	neutral	0.57	0.65	0.43	neutral	0.1	neutral	0.14	neutral	0.29	neutral	4	0.97	neutral	0.14	neutral	-2	neutral	0.68	deleterious	-1.96	low_impact	-0.07	medium_impact	-2.17	low_impact	0.68	0.85	7.79	12	0.51	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13651	13651	A	T	MI.22061	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1315	439	T	S	Acc/Tcc	-20	0	0.04	benign	0.12	neutral	0.42	neutral	1.22	neutral	1.59	neutral	-0.99	neutral_impact	-0.24	0.88	neutral	0.98	neutral	2.54	19.75	deleterious	0.71	0.75	0.46	neutral	0.1	neutral	0.2	neutral	0.32	neutral	4	0.51	neutral	0.65	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.16	medium_impact	-1.42	low_impact	0.65	0.8	7.79	12	0.52	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13652	13652	C	A	MI.22062	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1316	439	T	N	aCc/aAc	-9.46	0	0	possibly_damaging	0.82	neutral	0.31	neutral	0.94	neutral	-1.11	neutral	-2.25	low_impact	1.68	0.84	neutral	0.56	neutral	3.84	23.40	deleterious	0.75	0.8	0.54	disease	0.4	neutral	0.52	disease	0.63	disease	3	0.85	neutral	0.25	neutral	-3	neutral	0.72	deleterious	-1.37	low_impact	0.04	medium_impact	0.33	medium_impact	0.76	0.85	7.79	12	0.32	N	0.39	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13652	13652	C	G	MI.22063	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1316	439	T	S	aCc/aGc	-9.46	0	0	benign	0.12	neutral	0.42	neutral	1.22	neutral	1.59	neutral	-0.99	neutral_impact	-0.24	0.88	neutral	0.98	neutral	2.21	17.59	deleterious	0.71	0.75	0.46	neutral	0.1	neutral	0.2	neutral	0.32	neutral	4	0.51	neutral	0.65	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.16	medium_impact	-1.42	low_impact	0.65	0.8	7.79	12	0.49	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13652	13652	C	T	MI.22064	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1316	439	T	I	aCc/aTc	-9.46	0	0	probably_damaging	0.91	neutral	0.41	neutral	0.92	neutral	-1.67	deleterious	-3.04	medium_impact	2.23	0.84	neutral	0.54	neutral	4.15	23.80	deleterious	0.7	0.75	0.63	disease	0.29	neutral	0.52	disease	0.6	disease	2	0.91	neutral	0.25	neutral	1	deleterious	0.73	deleterious	-1.7	low_impact	0.15	medium_impact	0.83	medium_impact	0.42	0.8	7.79	12	0.31	N	0.59	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13654	13654	C	G	MI.22065	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1318	440	L	V	Ctt/Gtt	-7.17	0	0	benign	0.36	neutral	0.51	neutral	0.8	neutral	-1.34	neutral	-1.15	low_impact	1.89	0.82	neutral	0.96	neutral	0.91	10.12	neutral	0.65	0.7	NA	NA	0.28	neutral	0.45	neutral	0.19	neutral	6	0.41	neutral	0.58	deleterious	-6	neutral	0.32	neutral	-0.51	medium_impact	0.24	medium_impact	0.52	medium_impact	0.72	0.85	14.43	13.06	0.36	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13654	13654	C	A	MI.22066	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1318	440	L	I	Ctt/Att	-7.17	0	0	possibly_damaging	0.48	neutral	0.42	neutral	0.81	neutral	-1.22	neutral	-0.84	low_impact	1	0.81	neutral	0.98	neutral	1.57	13.67	neutral	0.58	0.65	NA	NA	0.17	neutral	0.26	neutral	0.23	neutral	5	0.55	neutral	0.47	deleterious	-3	neutral	0.39	neutral	-0.71	medium_impact	0.16	medium_impact	-0.29	medium_impact	0.76	0.85	14.43	13.06	0.41	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13654	13654	C	T	MI.22067	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1318	440	L	F	Ctt/Ttt	-7.17	0	0	benign	0.04	neutral	0.76	neutral	0.79	neutral	-1.43	neutral	-2.34	medium_impact	2.02	0.79	neutral	0.8	neutral	1.08	11.13	neutral	0.62	0.65	NA	NA	0.34	neutral	0.32	neutral	0.17	neutral	7	0.17	neutral	0.86	deleterious	-3	neutral	0.15	neutral	0.57	medium_impact	0.51	medium_impact	0.64	medium_impact	0.56	0.8	14.43	13.06	0.27	N	0.29	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13655	13655	T	C	MI.22068	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1319	440	L	P	cTt/cCt	-2.81	0	0	benign	0.03	neutral	0.24	neutral	0.69	deleterious	-3.32	deleterious	-3.07	medium_impact	2.1	0.83	neutral	0.57	neutral	2.02	16.37	deleterious	0.49	0.55	NA	NA	0.75	disease	0.56	disease	0.64	disease	3	0.75	neutral	0.61	deleterious	-3	neutral	0.26	neutral	0.69	medium_impact	-0.04	medium_impact	0.72	medium_impact	0.46	0.8	14.43	13.06	0.33	N	0.18	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13655	13655	T	A	MI.22069	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1319	440	L	H	cTt/cAt	-2.81	0	0	probably_damaging	0.95	neutral	0.56	neutral	0.67	deleterious	-4.07	deleterious	-3.8	medium_impact	1.95	0.79	neutral	0.65	neutral	4.15	23.80	deleterious	0.4	0.5	NA	NA	0.62	disease	0.38	neutral	0.48	neutral	0	0.95	neutral	0.31	neutral	1	deleterious	0.76	deleterious	-1.96	low_impact	0.29	medium_impact	0.58	medium_impact	0.53	0.8	14.43	13.06	0.21	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6061	6061	T	A	MI.2207	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	158	53	I	N	aTc/aAc	4.75	1	0	probably_damaging	0.94	deleterious	0	neutral	2.76	neutral	-1.92	deleterious	-3.65	high_impact	4.05	0.61	neutral	0.41	neutral	3.99	23.60	deleterious	0.21	0.55	0.41	neutral	0.85	disease	0.6	disease	0.75	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.76	deleterious	-1.88	low_impact	-1.48	low_impact	2.64	high_impact	0.76	0.9	8.97	39.65	0.49	P	0.94	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13655	13655	T	G	MI.22070	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1319	440	L	R	cTt/cGt	-2.81	0	0	possibly_damaging	0.83	neutral	0.37	neutral	0.68	deleterious	-3.92	deleterious	-3.1	medium_impact	2.44	0.72	neutral	0.39	neutral	4.29	24.00	deleterious	0.44	0.55	NA	NA	0.71	disease	0.66	disease	0.67	disease	3	0.84	neutral	0.27	neutral	0	NA	0.77	deleterious	-1.4	low_impact	0.11	medium_impact	1.03	medium_impact	0.65	0.8	14.43	13.06	0.28	N	0.57	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13657	13657	A	G	MI.22071	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1321	441	T	A	Act/Gct	-9.69	0	0	benign	0.01	neutral	0.55	neutral	1.01	neutral	0.21	neutral	-0.74	neutral_impact	0.3	0.87	neutral	0.87	neutral	-0.26	0.82	neutral	0.61	0.65	0.43	neutral	0.11	neutral	0.38	neutral	0.33	neutral	3	0.44	neutral	0.77	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	0.28	medium_impact	-0.93	medium_impact	0.35	0.8	24.54	14.03	0.39	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13657	13657	A	T	MI.22072	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1321	441	T	S	Act/Tct	-9.69	0	0	benign	0.27	neutral	0.46	neutral	1.11	neutral	-0.29	neutral	-1.03	neutral_impact	-0.76	0.81	neutral	0.94	neutral	-0.99	0.02	neutral	0.68	0.7	0.38	neutral	0.03	neutral	0.15	neutral	0.2	neutral	6	0.45	neutral	0.6	deleterious	-6	neutral	0.26	neutral	-0.34	medium_impact	0.19	medium_impact	-1.9	low_impact	0.71	0.85	24.54	14.03	0.51	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13657	13657	A	C	MI.22073	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1321	441	T	P	Act/Cct	-9.69	0	0	possibly_damaging	0.66	neutral	0.24	neutral	0.93	neutral	-1.26	neutral	-2.1	neutral_impact	0.6	0.82	neutral	0.83	neutral	2.02	16.35	deleterious	0.43	0.55	0.5	neutral	0.45	neutral	0.22	neutral	0.42	neutral	2	0.79	neutral	0.29	neutral	-3	neutral	0.64	deleterious	-1.02	low_impact	-0.04	medium_impact	-0.66	medium_impact	0.67	0.85	24.54	14.03	0.36	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13658	13658	C	T	MI.22074	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1322	441	T	I	aCt/aTt	-0.98	0	0	benign	0.01	neutral	0.42	neutral	1	neutral	-2.25	neutral	1.26	neutral_impact	0.18	0.86	neutral	0.98	neutral	-0.27	0.79	neutral	0.63	0.65	0.48	neutral	0.13	neutral	0.28	neutral	0.27	neutral	5	0.57	neutral	0.71	deleterious	-6	neutral	0.13	neutral	1.15	medium_impact	0.16	medium_impact	-1.04	low_impact	0.54	0.8	24.54	14.03	0.42	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13658	13658	C	A	MI.22075	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1322	441	T	N	aCt/aAt	-0.98	0	0	possibly_damaging	0.73	neutral	0.34	neutral	1.04	neutral	-0.85	neutral	-2.1	neutral_impact	0.76	0.83	neutral	0.94	neutral	2.15	17.17	deleterious	0.73	0.75	0.54	disease	0.26	neutral	0.39	neutral	0.48	neutral	0	0.77	neutral	0.31	neutral	-3	neutral	0.61	deleterious	-1.16	low_impact	0.07	medium_impact	-0.51	medium_impact	0.70	0.85	24.54	14.03	0.37	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13658	13658	C	G	MI.22076	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1322	441	T	S	aCt/aGt	-0.98	0	0	benign	0.27	neutral	0.46	neutral	1.11	neutral	-0.29	neutral	-1.03	neutral_impact	-0.76	0.81	neutral	0.94	neutral	-0.81	0.04	neutral	0.68	0.7	0.38	neutral	0.03	neutral	0.15	neutral	0.2	neutral	6	0.45	neutral	0.6	deleterious	-6	neutral	0.26	neutral	-0.34	medium_impact	0.19	medium_impact	-1.9	low_impact	0.71	0.85	24.54	14.03	0.51	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13660	13660	A	G	MI.22077	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1324	442	N	D	Aac/Gac	-2.35	0	0	benign	0.18	neutral	0.22	neutral	0.92	neutral	-0.33	neutral	-1.47	low_impact	1.76	0.73	neutral	0.52	neutral	2.42	18.92	deleterious	0.85	0.9	0.46	neutral	0.24	neutral	0.49	neutral	0.45	neutral	1	0.74	neutral	0.52	deleterious	-6	neutral	0.48	deleterious	-0.12	medium_impact	-0.07	medium_impact	0.41	medium_impact	0.55	0.8	28.03	14.28	0.44	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13660	13660	A	T	MI.22078	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1324	442	N	Y	Aac/Tac	-2.35	0	0	benign	0.01	neutral	1	neutral	0.9	neutral	-2.61	neutral	-2.24	low_impact	1.21	0.79	neutral	0.63	neutral	2.59	20.20	deleterious	0.5	0.6	0.64	disease	0.34	neutral	0.34	neutral	0.62	disease	2	0.01	neutral	1	deleterious	-6	neutral	0.70	deleterious	1.15	medium_impact	1.89	high_impact	-0.1	medium_impact	0.48	0.8	28.03	14.28	0.21	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13660	13660	A	C	MI.22079	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1324	442	N	H	Aac/Cac	-2.35	0	0	benign	0.02	neutral	0.54	neutral	0.91	neutral	0.65	neutral	-1.69	low_impact	1.21	0.75	neutral	0.8	neutral	2.03	16.41	deleterious	0.71	0.75	0.57	disease	0.22	neutral	0.45	neutral	0.47	neutral	1	0.44	neutral	0.76	deleterious	-6	neutral	0.65	deleterious	0.86	medium_impact	0.27	medium_impact	-0.1	medium_impact	0.53	0.8	28.03	14.28	0.31	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6061	6061	T	G	MI.2208	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	158	53	I	S	aTc/aGc	4.75	1	0	possibly_damaging	0.79	deleterious	0	neutral	2.81	neutral	-1.22	deleterious	-2.99	medium_impact	3.16	0.66	neutral	0.46	neutral	2.48	19.31	deleterious	0.23	0.55	0.31	neutral	0.86	disease	0.49	neutral	0.73	disease	5	1	deleterious	0.11	neutral	4	deleterious	0.57	deleterious	-1.3	low_impact	-1.48	low_impact	1.82	medium_impact	0.63	0.9	8.97	39.65	0.49	P	0.62	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13661	13661	A	G	MI.22080	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1325	442	N	S	aAc/aGc	-3.27	0	0	benign	0.01	neutral	0.46	neutral	1.06	neutral	-0.31	neutral	-0.17	neutral_impact	-0.18	0.85	neutral	0.96	neutral	-0.03	2.28	deleterious	0.84	0.85	0.45	neutral	0.19	neutral	0.27	neutral	0.36	neutral	3	0.53	neutral	0.73	deleterious	-6	neutral	0.16	neutral	1.15	medium_impact	0.19	medium_impact	-1.37	low_impact	0.15	0.8	28.03	14.28	0.37	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13661	13661	A	C	MI.22081	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1325	442	N	T	aAc/aCc	-3.27	0	0	benign	0.01	neutral	0.45	neutral	0.95	neutral	-0.8	neutral	-0.21	neutral_impact	-0.24	0.86	neutral	0.98	neutral	0.43	6.89	deleterious	0.71	0.75	0.56	disease	0.23	neutral	0.23	neutral	0.55	disease	1	0.54	neutral	0.72	deleterious	-6	neutral	0.43	deleterious	1.15	medium_impact	0.18	medium_impact	-1.42	low_impact	0.47	0.8	28.03	14.28	0.37	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13661	13661	A	T	MI.22082	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1325	442	N	I	aAc/aTc	-3.27	0	0	benign	0.01	neutral	0.44	neutral	0.93	neutral	-2.73	neutral	-1.6	low_impact	1.07	0.87	neutral	0.97	neutral	2.79	21.30	deleterious	0.5	0.6	0.85	disease	0.35	neutral	0.42	neutral	0.65	disease	3	0.55	neutral	0.72	deleterious	-6	neutral	0.70	deleterious	1.15	medium_impact	0.18	medium_impact	-0.23	medium_impact	0.42	0.8	28.03	14.28	0.35	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13662	13662	C	A	MI.22083	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1326	442	N	K	aaC/aaA	-1.89	0	0	benign	0.18	neutral	0.31	neutral	0.96	neutral	0.1	neutral	-1.36	neutral_impact	0.48	0.74	neutral	0.67	neutral	2.98	22.20	deleterious	0.86	0.9	0.45	neutral	0.34	neutral	0.52	disease	0.49	neutral	0	0.63	neutral	0.57	deleterious	-6	neutral	0.53	deleterious	-0.12	medium_impact	0.04	medium_impact	-0.76	medium_impact	0.72	0.85	28.03	14.28	0.4	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13662	13662	C	G	MI.22084	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1326	442	N	K	aaC/aaG	-1.89	0	0	benign	0.18	neutral	0.31	neutral	0.96	neutral	0.1	neutral	-1.36	neutral_impact	0.48	0.74	neutral	0.67	neutral	2.45	19.15	deleterious	0.86	0.9	0.45	neutral	0.34	neutral	0.52	disease	0.49	neutral	0	0.63	neutral	0.57	deleterious	-6	neutral	0.53	deleterious	-0.12	medium_impact	0.04	medium_impact	-0.76	medium_impact	0.72	0.85	28.03	14.28	0.4	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13663	13663	A	C	MI.22085	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1327	443	I	L	Att/Ctt	-7.62	0	0	possibly_damaging	0.61	neutral	0.72	neutral	0.99	neutral	-0.07	neutral	-1.4	low_impact	0.94	0.79	neutral	0.79	neutral	3.62	23.20	deleterious	0.7	0.75	0.48	neutral	0.42	neutral	0.36	neutral	0.43	neutral	1	0.53	neutral	0.56	deleterious	-3	neutral	0.65	deleterious	-0.93	medium_impact	0.46	medium_impact	-0.34	medium_impact	0.53	0.8	8.96	9.53	0.22	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13663	13663	A	G	MI.22086	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1327	443	I	V	Att/Gtt	-7.62	0	0	benign	0.12	neutral	0.52	neutral	0.85	neutral	-0.91	neutral	-0.71	medium_impact	2.3	0.82	neutral	0.92	neutral	3.00	22.20	deleterious	0.63	0.65	0.37	neutral	0.22	neutral	0.41	neutral	0.37	neutral	3	0.39	neutral	0.7	deleterious	-3	neutral	0.62	deleterious	0.08	medium_impact	0.25	medium_impact	0.9	medium_impact	0.42	0.8	8.96	9.53	0.37	N	0.74	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13663	13663	A	T	MI.22087	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1327	443	I	F	Att/Ttt	-7.62	0	0	probably_damaging	0.97	neutral	0.79	neutral	0.75	neutral	-2.12	deleterious	-3.03	medium_impact	2.06	0.74	neutral	0.7	neutral	3.66	23.20	deleterious	0.58	0.65	0.61	disease	0.63	disease	0.58	disease	0.53	disease	1	0.97	neutral	0.41	neutral	1	deleterious	0.74	deleterious	-2.18	low_impact	0.55	medium_impact	0.68	medium_impact	0.57	0.8	8.96	9.53	0.22	N	0.96	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13664	13664	T	C	MI.22088	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1328	443	I	T	aTt/aCt	1.54	0.03	0	probably_damaging	0.91	neutral	0.41	neutral	0.77	neutral	-1.86	deleterious	-3.69	low_impact	1.77	0.82	neutral	0.92	neutral	3.49	23.10	deleterious	0.58	0.65	0.67	disease	0.68	disease	0.57	disease	0.55	disease	1	0.91	neutral	0.25	neutral	-2	neutral	0.76	deleterious	-1.7	low_impact	0.15	medium_impact	0.41	medium_impact	0.36	0.8	8.96	9.53	0.3	N	0.96	disease_causing	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13664	13664	T	A	MI.22089	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1328	443	I	N	aTt/aAt	1.54	0.03	0	probably_damaging	0.98	neutral	0.35	neutral	0.7	deleterious	-3.5	deleterious	-5.4	medium_impact	3.34	0.74	neutral	0.55	neutral	4.56	24.40	deleterious	0.53	0.6	0.81	disease	0.8	disease	0.64	disease	0.73	disease	5	0.99	deleterious	0.19	neutral	1	deleterious	0.81	deleterious	-2.35	low_impact	0.08	medium_impact	1.85	medium_impact	0.60	0.8	8.96	9.53	0.33	N	0.99	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6061	6061	T	C	MI.2209	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	158	53	I	T	aTc/aCc	4.75	1	0	possibly_damaging	0.53	deleterious	0.02	neutral	2.9	neutral	-1.13	neutral	-2.31	medium_impact	2.1	0.61	neutral	0.55	neutral	0.26	5.26	deleterious	0.39	0.55	0.27	neutral	0.73	disease	0.33	neutral	0.53	disease	1	0.98	neutral	0.25	neutral	4	deleterious	0.35	neutral	-0.81	medium_impact	-0.75	medium_impact	0.84	medium_impact	0.77	0.9	8.97	39.65	0.49	P	0.76	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13664	13664	T	G	MI.22090	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1328	443	I	S	aTt/aGt	1.54	0.03	0	probably_damaging	0.96	neutral	0.45	neutral	0.72	neutral	-2.72	deleterious	-4.43	medium_impact	2.64	0.83	neutral	0.55	neutral	4.39	24.10	deleterious	0.52	0.6	0.64	disease	0.79	disease	0.63	disease	0.64	disease	3	0.96	neutral	0.25	neutral	1	deleterious	0.78	deleterious	-2.06	low_impact	0.18	medium_impact	1.21	medium_impact	0.37	0.8	8.96	9.53	0.27	N	0.96	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13665	13665	T	G	MI.22091	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1329	443	I	M	atT/atG	1.77	0.05	0	probably_damaging	0.97	neutral	0.25	neutral	0.73	neutral	-2.45	neutral	-1.85	low_impact	1.51	0.79	neutral	0.93	neutral	2.44	19.09	deleterious	0.63	0.7	0.69	disease	0.38	neutral	0.37	neutral	0.63	disease	3	0.98	neutral	0.14	neutral	-2	neutral	0.71	deleterious	-2.18	low_impact	-0.03	medium_impact	0.18	medium_impact	0.61	0.8	8.96	9.53	0.42	N	0.76	disease_causing	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13665	13665	T	A	MI.22092	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1329	443	I	M	atT/atA	1.77	0.05	0	probably_damaging	0.97	neutral	0.25	neutral	0.73	neutral	-2.45	neutral	-1.85	low_impact	1.51	0.79	neutral	0.93	neutral	2.68	20.70	deleterious	0.63	0.7	0.69	disease	0.38	neutral	0.37	neutral	0.63	disease	3	0.98	neutral	0.14	neutral	-2	neutral	0.71	deleterious	-2.18	low_impact	-0.03	medium_impact	0.18	medium_impact	0.61	0.8	8.96	9.53	0.42	N	0.76	disease_causing	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13666	13666	A	T	MI.22093	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1330	444	N	Y	Aac/Tac	-10.6	0	0	probably_damaging	1	neutral	1	neutral	0.7	neutral	-2.62	deleterious	-7.18	medium_impact	3.35	0.74	neutral	0.09	damaging	3.83	23.40	deleterious	0.48	0.55	0.76	disease	0.73	disease	0.68	disease	0.69	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.79	deleterious	-3.6	low_impact	1.89	high_impact	1.86	medium_impact	0.42	0.8	4.81	7.19	0.18	N	0.99	polymorphism	0.93	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13666	13666	A	G	MI.22094	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1330	444	N	D	Aac/Gac	-10.6	0	0	probably_damaging	1	neutral	0.22	neutral	0.73	neutral	-0.95	deleterious	-4.49	medium_impact	2.41	0.73	neutral	0.2	damaging	3.99	23.60	deleterious	0.83	0.85	0.7	disease	0.48	neutral	0.48	neutral	0.56	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.07	medium_impact	1	medium_impact	0.55	0.8	4.81	7.19	0.31	N	0.94	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13666	13666	A	C	MI.22095	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1330	444	N	H	Aac/Cac	-10.6	0	0	probably_damaging	1	neutral	0.54	neutral	0.71	neutral	1.32	deleterious	-4.49	medium_impact	2.12	0.71	neutral	0.17	damaging	3.23	22.80	deleterious	0.76	0.8	0.32	neutral	0.52	disease	0.61	disease	0.46	neutral	1	1	deleterious	0.27	neutral	1	deleterious	0.70	deleterious	-3.6	low_impact	0.27	medium_impact	0.73	medium_impact	0.50	0.8	4.81	7.19	0.28	N	0.97	polymorphism	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13667	13667	A	G	MI.22096	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1331	444	N	S	aAc/aGc	2.46	0.96	0	probably_damaging	1	neutral	0.41	neutral	0.82	neutral	-0.3	deleterious	-4.48	medium_impact	2.27	0.77	neutral	0.28	damaging	3.20	22.70	deleterious	0.79	0.8	0.58	disease	0.58	disease	0.55	disease	0.48	neutral	0	1	deleterious	0.21	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.15	medium_impact	0.87	medium_impact	0.19	0.8	4.81	7.19	0.34	N	0.82	disease_causing	0.54	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13667	13667	A	C	MI.22097	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1331	444	N	T	aAc/aCc	2.46	0.96	0	probably_damaging	1	neutral	0.4	neutral	0.74	neutral	-0.9	deleterious	-5.38	medium_impact	2.71	0.71	neutral	0.16	damaging	3.55	23.10	deleterious	0.69	0.75	0.61	disease	0.73	disease	0.55	disease	0.59	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.14	medium_impact	1.27	medium_impact	0.49	0.8	4.81	7.19	0.34	N	0.94	disease_causing	0.8	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13667	13667	A	T	MI.22098	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1331	444	N	I	aAc/aTc	2.46	0.96	0	probably_damaging	1	neutral	0.4	neutral	0.68	neutral	-2.77	deleterious	-8.08	high_impact	3.69	0.71	neutral	0.09	damaging	4.02	23.60	deleterious	0.49	0.55	0.74	disease	0.75	disease	0.63	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.14	medium_impact	2.17	high_impact	0.39	0.8	4.81	7.19	0.41	N	0.99	disease_causing	0.92	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13668	13668	C	A	MI.22099	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1332	444	N	K	aaC/aaA	4.52	0.98	0	probably_damaging	1	neutral	0.31	neutral	0.78	neutral	-0.03	deleterious	-5.38	medium_impact	2.8	0.74	neutral	0.11	damaging	4.58	24.40	deleterious	0.8	0.85	0.46	neutral	0.74	disease	0.67	disease	0.64	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.04	medium_impact	1.36	medium_impact	0.56	0.8	4.81	7.19	0.43	N	1.00	disease_causing	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8630	8630	A	T	MI.221	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	104	35	K	M	aAa/aTa	-0.1	0	0	possibly_damaging	0.9	neutral	0.21	neutral	4.35	neutral	-0.92	deleterious	-2.59	low_impact	1.04	0.89	neutral	0.59	neutral	3.71	23.30	deleterious	0.38	0.65	0.81	disease	0.25	neutral	0.37	neutral	0.59	disease	2	0.93	neutral	0.16	neutral	-3	neutral	0.70	deleterious	-1.66	low_impact	-0.03	medium_impact	-0.21	medium_impact	0.41	0.9	20.35	18.29	0.44	N	0.70	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6062	6062	C	G	MI.2210	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	159	53	I	M	atC/atG	7.53	1	0	possibly_damaging	0.78	deleterious	0.04	neutral	2.76	neutral	-1.12	neutral	-1.17	medium_impact	2.86	0.66	neutral	0.52	neutral	1.58	13.74	neutral	0.48	0.55	0.46	neutral	0.54	disease	0.26	neutral	0.47	neutral	1	0.97	neutral	0.13	neutral	4	deleterious	0.46	deleterious	-1.27	low_impact	-0.58	medium_impact	1.54	medium_impact	0.85	0.9	8.97	39.65	0.56	P	0.76	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13668	13668	C	G	MI.22100	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1332	444	N	K	aaC/aaG	4.52	0.98	0	probably_damaging	1	neutral	0.31	neutral	0.78	neutral	-0.03	deleterious	-5.38	medium_impact	2.8	0.74	neutral	0.11	damaging	4.12	23.80	deleterious	0.8	0.85	0.46	neutral	0.74	disease	0.67	disease	0.64	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.04	medium_impact	1.36	medium_impact	0.56	0.8	4.81	7.19	0.42	N	1.00	disease_causing	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13669	13669	G	A	MI.22101	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1333	445	E	K	Gaa/Aaa	-4.87	0	0	probably_damaging	1	neutral	0.34	neutral	0.39	deleterious	-3.85	deleterious	-3.58	medium_impact	2.85	0.4	damaging	0.11	damaging	4.67	24.50	deleterious	0.68	0.7	0.71	disease	0.78	disease	0.75	disease	0.65	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.07	medium_impact	1.4	medium_impact	0.77	0.85	28.69	7.14	0.46	N	0.99	disease_causing	0.66	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13669	13669	G	C	MI.22102	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1333	445	E	Q	Gaa/Caa	-4.87	0	0	probably_damaging	1	neutral	0.32	neutral	0.38	deleterious	-4.13	deleterious	-2.67	medium_impact	3.13	0.43	damaging	0.16	damaging	3.51	23.10	deleterious	0.69	0.75	0.76	disease	0.67	disease	0.71	disease	0.73	disease	5	1	deleterious	0.16	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.05	medium_impact	1.66	medium_impact	0.72	0.85	28.69	7.14	0.4	N	0.89	polymorphism	0.69	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13670	13670	A	C	MI.22103	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1334	445	E	A	gAa/gCa	5.9	1	0	probably_damaging	1	neutral	0.55	neutral	0.38	deleterious	-4.14	deleterious	-5.38	high_impact	3.82	0.48	damaging	0.19	damaging	3.86	23.50	deleterious	0.54	0.6	0.77	disease	0.57	disease	0.73	disease	0.74	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.28	medium_impact	2.29	high_impact	0.68	0.85	28.69	7.14	0.59	P	0.75	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13670	13670	A	G	MI.22104	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1334	445	E	G	gAa/gGa	5.9	1	0	probably_damaging	1	neutral	0.35	neutral	0.38	deleterious	-4.1	deleterious	-6.28	medium_impact	3.48	0.46	damaging	0.17	damaging	4.47	24.20	deleterious	0.58	0.65	0.85	disease	0.58	disease	0.73	disease	0.76	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.08	medium_impact	1.98	medium_impact	0.56	0.8	28.69	7.14	0.63	P	0.51	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13670	13670	A	T	MI.22105	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1334	445	E	V	gAa/gTa	5.9	1	0	probably_damaging	1	neutral	0.52	neutral	0.37	deleterious	-4.42	deleterious	-6.28	high_impact	3.82	0.45	damaging	0.12	damaging	4.40	24.10	deleterious	0.39	0.5	0.83	disease	0.73	disease	0.74	disease	0.77	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.25	medium_impact	2.29	high_impact	0.80	0.85	28.69	7.14	0.61	P	0.81	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13671	13671	A	C	MI.22106	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1335	445	E	D	gaA/gaC	8.42	1	0	probably_damaging	1	neutral	0.24	neutral	0.77	neutral	-0.74	deleterious	-2.69	medium_impact	2.92	0.52	damaging	0.16	damaging	3.79	23.40	deleterious	0.72	0.75	0.46	neutral	0.48	neutral	0.57	disease	0.45	neutral	1	1	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.04	medium_impact	1.46	medium_impact	0.81	0.85	28.69	7.14	0.67	P	0.86	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13671	13671	A	T	MI.22107	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1335	445	E	D	gaA/gaT	8.42	1	0	probably_damaging	1	neutral	0.24	neutral	0.77	neutral	-0.74	deleterious	-2.69	medium_impact	2.92	0.52	damaging	0.16	damaging	3.91	23.50	deleterious	0.72	0.75	0.46	neutral	0.48	neutral	0.57	disease	0.45	neutral	1	1	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.04	medium_impact	1.46	medium_impact	0.81	0.85	28.69	7.14	0.68	P	0.86	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13672	13672	A	C	MI.22108	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1336	446	N	H	Aat/Cat	2	1	0	probably_damaging	1	neutral	0.54	neutral	0.73	deleterious	-3.46	deleterious	-4.41	medium_impact	3.1	0.7	neutral	0.17	damaging	3.11	22.50	deleterious	0.76	0.8	0.8	disease	0.69	disease	0.63	disease	0.65	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.27	medium_impact	1.63	medium_impact	0.43	0.8	2.65	7.99	0.32	N	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13672	13672	A	G	MI.22109	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1336	446	N	D	Aat/Gat	2	1	0	probably_damaging	1	neutral	0.22	neutral	0.78	neutral	-1.99	deleterious	-4.38	medium_impact	2.54	0.74	neutral	0.21	damaging	3.81	23.40	deleterious	0.79	0.8	0.68	disease	0.51	disease	0.62	disease	0.5	disease	0	1	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.07	medium_impact	1.12	medium_impact	0.55	0.8	2.65	7.99	0.46	N	0.94	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6062	6062	C	A	MI.2211	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	159	53	I	M	atC/atA	7.53	1	0	possibly_damaging	0.78	deleterious	0.04	neutral	2.76	neutral	-1.12	neutral	-1.17	medium_impact	2.86	0.66	neutral	0.52	neutral	2.02	16.34	deleterious	0.48	0.55	0.46	neutral	0.54	disease	0.26	neutral	0.47	neutral	1	0.97	neutral	0.13	neutral	4	deleterious	0.46	deleterious	-1.27	low_impact	-0.58	medium_impact	1.54	medium_impact	0.85	0.9	8.97	39.65	0.57	P	0.76	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13672	13672	A	T	MI.22110	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1336	446	N	Y	Aat/Tat	2	1	0	probably_damaging	1	neutral	1	neutral	0.73	deleterious	-3.68	deleterious	-7.04	medium_impact	3.29	0.74	neutral	0.11	damaging	3.70	23.30	deleterious	0.52	0.6	0.86	disease	0.76	disease	0.68	disease	0.76	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.82	deleterious	-3.6	low_impact	1.89	high_impact	1.8	medium_impact	0.44	0.8	2.65	7.99	0.29	N	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13673	13673	A	T	MI.22111	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1337	446	N	I	aAt/aTt	5.44	1	0	probably_damaging	1	neutral	0.42	neutral	0.72	deleterious	-4.01	deleterious	-7.9	medium_impact	2.95	0.7	neutral	0.12	damaging	3.86	23.40	deleterious	0.42	0.55	0.68	disease	0.77	disease	0.63	disease	0.68	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.16	medium_impact	1.49	medium_impact	0.39	0.8	2.65	7.99	0.43	N	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13673	13673	A	G	MI.22112	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1337	446	N	S	aAt/aGt	5.44	1	0	probably_damaging	1	neutral	0.42	neutral	0.86	neutral	-0.95	deleterious	-4.31	medium_impact	2.75	0.77	neutral	0.68	neutral	3.05	22.40	deleterious	0.76	0.8	0.32	neutral	0.51	disease	0.58	disease	0.45	neutral	1	1	deleterious	0.21	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.16	medium_impact	1.31	medium_impact	0.23	0.8	2.65	7.99	0.5	N	0.82	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13673	13673	A	C	MI.22113	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1337	446	N	T	aAt/aCt	5.44	1	0	probably_damaging	1	neutral	0.41	neutral	0.76	neutral	-2.4	deleterious	-5.18	medium_impact	2.29	0.8	neutral	0.83	neutral	3.34	22.90	deleterious	0.71	0.75	0.56	disease	0.7	disease	0.56	disease	0.54	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.15	medium_impact	0.89	medium_impact	0.42	0.8	2.65	7.99	0.45	N	0.94	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13674	13674	T	G	MI.22114	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1338	446	N	K	aaT/aaG	4.29	0.98	0	probably_damaging	1	neutral	0.31	neutral	0.82	neutral	-1.48	deleterious	-5.22	medium_impact	2.95	0.71	neutral	0.12	damaging	4.17	23.80	deleterious	0.77	0.8	0.5	disease	0.77	disease	0.66	disease	0.65	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.04	medium_impact	1.49	medium_impact	0.56	0.8	2.65	7.99	0.45	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13674	13674	T	A	MI.22115	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1338	446	N	K	aaT/aaA	4.29	0.98	0	probably_damaging	1	neutral	0.31	neutral	0.82	neutral	-1.48	deleterious	-5.22	medium_impact	2.95	0.71	neutral	0.12	damaging	4.41	24.10	deleterious	0.77	0.8	0.5	disease	0.77	disease	0.66	disease	0.65	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.04	medium_impact	1.49	medium_impact	0.56	0.8	2.65	7.99	0.48	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13675	13675	A	T	MI.22116	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1339	447	N	Y	Aac/Tac	-4.42	0	0	benign	0.11	neutral	1	neutral	0.74	deleterious	-3.72	deleterious	-6.81	medium_impact	2.25	0.76	neutral	0.57	neutral	1.68	14.31	neutral	0.5	0.6	0.88	disease	0.68	disease	0.56	disease	0.7	disease	4	0.11	neutral	0.95	deleterious	-3	neutral	0.28	neutral	0.12	medium_impact	1.89	high_impact	0.85	medium_impact	0.29	0.8	1.99	7.82	0.19	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13675	13675	A	C	MI.22117	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1339	447	N	H	Aac/Cac	-4.42	0	0	possibly_damaging	0.87	neutral	0.54	neutral	0.76	neutral	-2.94	deleterious	-4.24	low_impact	1.55	0.78	neutral	0.66	neutral	2.73	21.00	deleterious	0.78	0.8	0.76	disease	0.62	disease	0.56	disease	0.56	disease	1	0.86	neutral	0.34	neutral	-3	neutral	0.64	deleterious	-1.53	low_impact	0.27	medium_impact	0.21	medium_impact	0.33	0.8	1.99	7.82	0.22	N	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13675	13675	A	G	MI.22118	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1339	447	N	D	Aac/Gac	-4.42	0	0	benign	0.08	neutral	0.21	neutral	0.85	neutral	-1.18	deleterious	-3.91	low_impact	1.8	0.82	neutral	0.83	neutral	0.72	8.98	deleterious	0.83	0.85	0.52	disease	0.38	neutral	0.37	neutral	0.37	neutral	3	0.77	neutral	0.57	deleterious	-6	neutral	0.19	neutral	0.26	medium_impact	-0.09	medium_impact	0.44	medium_impact	0.44	0.8	1.99	7.82	0.43	N	0.65	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13676	13676	A	C	MI.22119	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1340	447	N	T	aAc/aCc	0.4	0	0	possibly_damaging	0.64	neutral	0.4	neutral	0.8	neutral	-1.88	deleterious	-4.97	low_impact	1.8	0.78	neutral	0.66	neutral	1.86	15.32	deleterious	0.68	0.7	0.49	neutral	0.61	disease	0.35	neutral	0.48	neutral	0	0.67	neutral	0.38	neutral	-3	neutral	0.50	deleterious	-0.98	medium_impact	0.14	medium_impact	0.44	medium_impact	0.36	0.8	1.99	7.82	0.3	N	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6063	6063	T	C	MI.2212	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	160	54	Y	H	Tac/Cac	-4.27	0	0	probably_damaging	0.96	deleterious	0	neutral	2	deleterious	-6.36	deleterious	-3.13	high_impact	4.39	0.58	damaging	0.02	damaging	3.44	23.00	deleterious	0.26	0.55	0.85	disease	0.87	disease	0.83	disease	0.88	disease	8	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-2.06	low_impact	-1.48	low_impact	2.95	high_impact	0.44	0.9	2.92	11.88	0.46	N	0.61	polymorphism	0.97	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13676	13676	A	G	MI.22120	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1340	447	N	S	aAc/aGc	0.4	0	0	benign	0.13	neutral	0.41	neutral	0.87	neutral	-0.99	deleterious	-3.99	low_impact	1.43	0.83	neutral	0.92	neutral	1.52	13.40	neutral	0.79	0.8	0.5	neutral	0.45	neutral	0.38	neutral	0.21	neutral	6	0.52	neutral	0.64	deleterious	-6	neutral	0.41	neutral	0.04	medium_impact	0.15	medium_impact	0.1	medium_impact	0.15	0.8	1.99	7.82	0.38	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	COSM488750	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13676	13676	A	T	MI.22121	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1340	447	N	I	aAc/aTc	0.4	0	0	probably_damaging	0.91	neutral	0.4	neutral	0.75	deleterious	-3.3	deleterious	-7.63	medium_impact	2.65	0.85	neutral	0.65	neutral	3.78	23.40	deleterious	0.4	0.5	0.77	disease	0.69	disease	0.6	disease	0.63	disease	3	0.91	neutral	0.25	neutral	1	deleterious	0.68	deleterious	-1.7	low_impact	0.14	medium_impact	1.22	medium_impact	0.27	0.8	1.99	7.82	0.32	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13677	13677	C	A	MI.22122	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1341	447	N	K	aaC/aaA	3.15	0.1	0	possibly_damaging	0.64	neutral	0.29	neutral	0.83	neutral	-1.44	deleterious	-5.02	medium_impact	3	0.74	neutral	0.51	neutral	3.03	22.30	deleterious	0.81	0.85	0.57	disease	0.72	disease	0.63	disease	0.63	disease	3	0.75	neutral	0.33	neutral	0	NA	0.57	deleterious	-0.98	medium_impact	0.02	medium_impact	1.54	medium_impact	0.48	0.8	1.99	7.82	0.4	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13677	13677	C	G	MI.22123	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1341	447	N	K	aaC/aaG	3.15	0.1	0	possibly_damaging	0.64	neutral	0.29	neutral	0.83	neutral	-1.44	deleterious	-5.02	medium_impact	3	0.74	neutral	0.51	neutral	2.59	20.10	deleterious	0.81	0.85	0.57	disease	0.72	disease	0.63	disease	0.63	disease	3	0.75	neutral	0.33	neutral	0	NA	0.57	deleterious	-0.98	medium_impact	0.02	medium_impact	1.54	medium_impact	0.48	0.8	1.99	7.82	0.39	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13678	13678	C	A	MI.22124	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1342	448	P	T	Ccc/Acc	-0.52	0	0	possibly_damaging	0.64	neutral	0.41	neutral	0.89	neutral	-1.97	deleterious	-5.61	medium_impact	2.08	0.86	neutral	0.94	neutral	3.62	23.20	deleterious	0.48	0.55	0.62	disease	0.51	disease	0.3	neutral	0.49	neutral	0	0.67	neutral	0.39	neutral	0	NA	0.56	deleterious	-0.98	medium_impact	0.15	medium_impact	0.7	medium_impact	0.49	0.8	2.65	8.71	0.35	N	0.91	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13678	13678	C	T	MI.22125	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1342	448	P	S	Ccc/Tcc	-0.52	0	0	benign	0.09	neutral	0.43	neutral	0.92	neutral	-1.86	deleterious	-5.91	medium_impact	2.31	0.87	neutral	0.76	neutral	2.05	16.52	deleterious	0.54	0.6	0.64	disease	0.53	disease	0.32	neutral	0.49	neutral	0	0.51	neutral	0.67	deleterious	-3	neutral	0.26	neutral	0.21	medium_impact	0.17	medium_impact	0.91	medium_impact	0.21	0.8	2.65	8.71	0.37	N	0.78	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13678	13678	C	G	MI.22126	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1342	448	P	A	Ccc/Gcc	-0.52	0	0	benign	0.4	neutral	0.53	neutral	0.9	neutral	-1.06	deleterious	-6.03	medium_impact	3.06	0.8	neutral	0.72	neutral	1.61	13.89	neutral	0.48	0.55	0.51	disease	0.35	neutral	0.57	disease	0.46	neutral	1	0.41	neutral	0.57	deleterious	-3	neutral	0.44	deleterious	-0.58	medium_impact	0.26	medium_impact	1.59	medium_impact	0.62	0.8	2.65	8.71	0.32	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13679	13679	C	A	MI.22127	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1343	448	P	H	cCc/cAc	-0.06	0	0	probably_damaging	0.96	neutral	0.54	neutral	0.84	deleterious	-3.59	deleterious	-6.98	medium_impact	3.06	0.77	neutral	0.59	neutral	4.13	23.80	deleterious	0.42	0.55	0.79	disease	0.64	disease	0.55	disease	0.6	disease	2	0.96	neutral	0.29	neutral	1	deleterious	0.77	deleterious	-2.06	low_impact	0.27	medium_impact	1.59	medium_impact	0.40	0.8	2.65	8.71	0.25	N	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13679	13679	C	G	MI.22128	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1343	448	P	R	cCc/cGc	-0.06	0	0	probably_damaging	0.91	neutral	0.36	neutral	0.87	neutral	-1.92	deleterious	-6.87	medium_impact	2.86	0.74	neutral	0.55	neutral	3.63	23.20	deleterious	0.36	0.5	0.66	disease	0.68	disease	0.67	disease	0.68	disease	4	0.91	neutral	0.23	neutral	1	deleterious	0.72	deleterious	-1.7	low_impact	0.1	medium_impact	1.41	medium_impact	0.47	0.8	2.65	8.71	0.29	N	0.64	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13679	13679	C	T	MI.22129	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1343	448	P	L	cCc/cTc	-0.06	0	0	benign	0.08	neutral	0.67	neutral	0.92	neutral	-1.07	deleterious	-7.62	medium_impact	2.37	0.82	neutral	0.65	neutral	4.36	24.10	deleterious	0.47	0.55	0.37	neutral	0.6	disease	0.55	disease	0.47	neutral	1	0.24	neutral	0.8	deleterious	-3	neutral	0.61	deleterious	0.26	medium_impact	0.4	medium_impact	0.96	medium_impact	0.66	0.8	2.65	8.71	0.28	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6063	6063	T	A	MI.2213	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	160	54	Y	N	Tac/Aac	-4.27	0	0	probably_damaging	1	deleterious	0	neutral	1.99	deleterious	-8.03	deleterious	-5.61	high_impact	5.08	0.58	damaging	0.04	damaging	3.87	23.50	deleterious	0.22	0.55	0.91	disease	0.9	disease	0.77	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.24	0.9	2.92	11.88	0.58	P	0.94	polymorphism	0.75	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13681	13681	A	G	MI.22130	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1345	449	T	A	Acc/Gcc	-9.46	0	0.02	benign	0.01	neutral	0.51	neutral	0.95	neutral	-0.44	neutral	-0.25	neutral_impact	0.21	0.78	neutral	0.88	neutral	-0.07	1.98	neutral	0.68	0.7	0.5	neutral	0.05	neutral	0.18	neutral	0.18	neutral	6	0.48	neutral	0.75	deleterious	-6	neutral	0.13	neutral	1.15	medium_impact	0.24	medium_impact	-1.01	low_impact	0.35	0.8	33.67	22.11	0.46	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13681	13681	A	C	MI.22131	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1345	449	T	P	Acc/Ccc	-9.46	0	0.02	possibly_damaging	0.66	neutral	0.29	neutral	0.87	neutral	-2.59	neutral	-0.86	neutral_impact	0.77	0.82	neutral	0.9	neutral	2.50	19.48	deleterious	0.25	0.45	0.44	neutral	0.46	neutral	0.49	neutral	0.47	neutral	1	0.76	neutral	0.32	neutral	-3	neutral	0.63	deleterious	-1.02	low_impact	0.02	medium_impact	-0.5	medium_impact	0.51	0.8	33.67	22.11	0.38	N	0.70	polymorphism	1	0.01	rs386829187	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13681	13681	A	T	MI.22132	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1345	449	T	S	Acc/Tcc	-9.46	0	0.02	benign	0.03	neutral	0.42	neutral	0.98	neutral	-0.99	neutral	0.1	neutral_impact	0.77	0.86	neutral	0.97	neutral	0.09	3.46	deleterious	0.58	0.65	0.51	disease	0.09	neutral	0.17	neutral	0.29	neutral	4	0.55	neutral	0.7	deleterious	-6	neutral	0.15	neutral	0.69	medium_impact	0.16	medium_impact	-0.5	medium_impact	0.60	0.8	33.67	22.11	0.55	N	0.21	polymorphism	1	0.00	rs386829187	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13682	13682	C	T	MI.22133	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1346	449	T	I	aCc/aTc	-8.31	0	0	benign	0.37	neutral	0.48	neutral	1	neutral	-0.46	neutral	-0.28	low_impact	0.97	0.78	neutral	0.71	neutral	2.16	17.28	deleterious	0.45	0.55	0.42	neutral	0.2	neutral	0.35	neutral	0.37	neutral	3	0.45	neutral	0.56	deleterious	-6	neutral	0.53	deleterious	-0.53	medium_impact	0.21	medium_impact	-0.32	medium_impact	0.55	0.8	33.67	22.11	0.34	N	0.22	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13682	13682	C	A	MI.22134	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1346	449	T	N	aCc/aAc	-8.31	0	0	benign	0.37	neutral	0.37	neutral	0.98	neutral	-2.2	neutral	-0.47	neutral_impact	-0.48	0.81	neutral	0.93	neutral	1.59	13.79	neutral	0.58	0.65	0.59	disease	0.16	neutral	0.19	neutral	0.32	neutral	4	0.56	neutral	0.5	deleterious	-6	neutral	0.51	deleterious	-0.53	medium_impact	0.11	medium_impact	-1.64	low_impact	0.67	0.85	33.67	22.11	0.43	N	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13682	13682	C	G	MI.22135	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1346	449	T	S	aCc/aGc	-8.31	0	0	benign	0.03	neutral	0.42	neutral	0.98	neutral	-0.99	neutral	0.1	neutral_impact	0.77	0.86	neutral	0.97	neutral	-0.25	0.88	neutral	0.58	0.65	0.51	disease	0.09	neutral	0.17	neutral	0.29	neutral	4	0.55	neutral	0.7	deleterious	-6	neutral	0.15	neutral	0.69	medium_impact	0.16	medium_impact	-0.5	medium_impact	0.60	0.8	33.67	22.11	0.49	N	0.21	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13684	13684	C	G	MI.22136	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1348	450	L	V	Cta/Gta	-6.25	0	0	possibly_damaging	0.9	neutral	0.55	neutral	0.92	neutral	-0.6	deleterious	-2.5	low_impact	1.4	0.68	neutral	0.42	neutral	1.61	13.91	neutral	0.42	0.55	0.6	disease	0.06	neutral	0.18	neutral	0.36	neutral	3	0.88	neutral	0.33	neutral	-3	neutral	0.69	deleterious	-1.65	low_impact	0.28	medium_impact	0.08	medium_impact	0.65	0.8	2.99	8.09	0.34	N	0.81	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13684	13684	C	A	MI.22137	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1348	450	L	M	Cta/Ata	-6.25	0	0	possibly_damaging	0.76	neutral	0.25	neutral	0.97	neutral	1.12	neutral	-1.51	low_impact	1.49	0.73	neutral	0.65	neutral	2.64	20.40	deleterious	0.35	0.5	0.3	neutral	0.18	neutral	0.25	neutral	0.34	neutral	3	0.84	neutral	0.25	neutral	-3	neutral	0.67	deleterious	-1.22	low_impact	-0.03	medium_impact	0.16	medium_impact	0.60	0.8	2.99	8.09	0.44	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13685	13685	T	C	MI.22138	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1349	450	L	P	cTa/cCa	-0.75	0	0	probably_damaging	1	neutral	0.28	neutral	0.73	deleterious	-3.64	deleterious	-6.07	low_impact	1.9	0.58	damaging	0.13	damaging	4.01	23.60	deleterious	0.18	0.45	0.81	disease	0.8	disease	0.72	disease	0.78	disease	6	1	deleterious	0.14	neutral	-2	neutral	0.89	deleterious	-3.6	low_impact	0.01	medium_impact	0.53	medium_impact	0.61	0.8	2.99	8.09	0.21	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13685	13685	T	A	MI.22139	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1349	450	L	Q	cTa/cAa	-0.75	0	0	probably_damaging	0.99	neutral	0.38	neutral	0.74	deleterious	-3.28	deleterious	-5.14	medium_impact	2.1	0.71	neutral	0.18	damaging	4.17	23.80	deleterious	0.22	0.45	0.84	disease	0.65	disease	0.5	neutral	0.62	disease	2	0.99	deleterious	0.2	neutral	1	deleterious	0.84	deleterious	-2.64	low_impact	0.12	medium_impact	0.72	medium_impact	0.68	0.85	2.99	8.09	0.26	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6063	6063	T	G	MI.2214	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	160	54	Y	D	Tac/Gac	-4.27	0	0	probably_damaging	1	deleterious	0	neutral	1.99	deleterious	-8.98	deleterious	-6.22	high_impact	5.08	0.5	damaging	0.03	damaging	3.80	23.40	deleterious	0.14	0.55	0.94	disease	0.91	disease	0.84	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.24	0.9	2.92	11.88	0.5	P	0.98	polymorphism	0.8	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13685	13685	T	G	MI.22140	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1349	450	L	R	cTa/cGa	-0.75	0	0	probably_damaging	0.99	neutral	0.43	neutral	0.73	deleterious	-3.03	deleterious	-5.18	medium_impact	3.25	0.64	neutral	0.07	damaging	4.31	24.00	deleterious	0.21	0.45	0.86	disease	0.75	disease	0.73	disease	0.8	disease	6	0.99	deleterious	0.22	neutral	1	deleterious	0.88	deleterious	-2.64	low_impact	0.17	medium_impact	1.77	medium_impact	0.57	0.8	2.99	8.09	0.24	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13687	13687	C	A	MI.22141	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1351	451	L	M	Cta/Ata	-6.94	0	0	benign	0.29	neutral	0.23	neutral	0.77	neutral	-1.96	neutral	-0.42	neutral_impact	-0.05	0.79	neutral	0.92	neutral	2.51	19.53	deleterious	0.36	0.5	0.69	disease	0.21	neutral	0.19	neutral	0.52	disease	0	0.72	neutral	0.47	deleterious	-6	neutral	0.70	deleterious	-0.38	medium_impact	-0.06	medium_impact	-1.25	low_impact	0.83	0.85	20.73	16.89	0.43	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13687	13687	C	G	MI.22142	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1351	451	L	V	Cta/Gta	-6.94	0	0	possibly_damaging	0.62	neutral	0.5	neutral	0.89	neutral	-1.28	neutral	0.4	low_impact	0.98	0.8	neutral	0.93	neutral	2.46	19.21	deleterious	0.42	0.55	0.51	disease	0.3	neutral	0.24	neutral	0.36	neutral	3	0.6	neutral	0.44	neutral	-3	neutral	0.68	deleterious	-0.95	medium_impact	0.23	medium_impact	-0.31	medium_impact	0.56	0.8	20.73	16.89	0.35	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13688	13688	T	A	MI.22143	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1352	451	L	Q	cTa/cAa	0.4	0	0	probably_damaging	0.94	neutral	0.28	neutral	0.75	deleterious	-3.68	deleterious	-2.96	medium_impact	2.13	0.75	neutral	0.27	damaging	4.28	24.00	deleterious	0.27	0.45	0.75	disease	0.66	disease	0.56	disease	0.72	disease	4	0.95	neutral	0.17	neutral	1	deleterious	0.80	deleterious	-1.88	low_impact	0.01	medium_impact	0.74	medium_impact	0.51	0.8	20.73	16.89	0.28	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13688	13688	T	C	MI.22144	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1352	451	L	P	cTa/cCa	0.4	0	0	probably_damaging	0.96	neutral	0.26	neutral	0.74	deleterious	-4.46	deleterious	-3.29	medium_impact	2.13	0.57	damaging	0.19	damaging	4.05	23.70	deleterious	0.18	0.45	0.9	disease	0.83	disease	0.7	disease	0.83	disease	7	0.97	neutral	0.15	neutral	1	deleterious	0.88	deleterious	-2.06	low_impact	-0.02	medium_impact	0.74	medium_impact	0.45	0.8	20.73	16.89	0.23	N	0.91	polymorphism	1	0.20	.	.	.	.	.	.	COSM488751	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13688	13688	T	G	MI.22145	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1352	451	L	R	cTa/cGa	0.4	0	0	possibly_damaging	0.82	neutral	0.34	neutral	0.75	neutral	-2.95	deleterious	-3.04	low_impact	1.79	0.66	neutral	0.24	damaging	4.27	23.90	deleterious	0.25	0.45	0.62	disease	0.78	disease	0.7	disease	0.78	disease	6	0.84	neutral	0.26	neutral	-3	neutral	0.83	deleterious	-1.37	low_impact	0.07	medium_impact	0.43	medium_impact	0.52	0.8	20.73	16.89	0.24	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13690	13690	A	T	MI.22146	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1354	452	N	Y	Aac/Tac	-12.67	0	0	probably_damaging	0.98	neutral	1	neutral	0.72	deleterious	-3.62	deleterious	-6.7	medium_impact	3.19	0.74	neutral	0.41	neutral	3.78	23.40	deleterious	0.48	0.55	0.67	disease	0.85	disease	0.68	disease	0.68	disease	4	0.98	deleterious	0.51	deleterious	1	deleterious	0.81	deleterious	-2.35	low_impact	1.89	high_impact	1.71	medium_impact	0.46	0.8	4.48	7.21	0.21	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13690	13690	A	C	MI.22147	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1354	452	N	H	Aac/Cac	-12.67	0	0	probably_damaging	0.98	neutral	0.54	neutral	0.72	deleterious	-3.54	deleterious	-4.08	medium_impact	3.19	0.79	neutral	0.47	neutral	3.13	22.60	deleterious	0.52	0.6	0.82	disease	0.78	disease	0.65	disease	0.7	disease	4	0.97	neutral	0.28	neutral	1	deleterious	0.80	deleterious	-2.35	low_impact	0.27	medium_impact	1.71	medium_impact	0.53	0.8	4.48	7.21	0.22	N	0.78	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13690	13690	A	G	MI.22148	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1354	452	N	D	Aac/Gac	-12.67	0	0	possibly_damaging	0.8	neutral	0.21	neutral	0.75	neutral	-2.54	deleterious	-4.2	high_impact	3.75	0.7	neutral	0.43	neutral	3.58	23.20	deleterious	0.65	0.7	0.91	disease	0.75	disease	0.7	disease	0.79	disease	6	0.88	neutral	0.21	neutral	1	deleterious	0.68	deleterious	-1.32	low_impact	-0.09	medium_impact	2.22	high_impact	0.59	0.8	4.48	7.21	0.38	N	0.89	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13691	13691	A	T	MI.22149	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1355	452	N	I	aAc/aTc	3.83	0.78	0	probably_damaging	0.97	neutral	0.4	neutral	0.73	deleterious	-3.02	deleterious	-7.64	medium_impact	3.4	0.73	neutral	0.52	neutral	3.87	23.50	deleterious	0.43	0.55	0.41	neutral	0.83	disease	0.63	disease	0.55	disease	1	0.97	neutral	0.22	neutral	1	deleterious	0.75	deleterious	-2.18	low_impact	0.14	medium_impact	1.9	medium_impact	0.38	0.8	4.48	7.21	0.37	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6064	6064	A	T	MI.2215	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	161	54	Y	F	tAc/tTc	7.53	1	0	benign	0.03	deleterious	0.03	neutral	2.66	neutral	-0.77	neutral	-2.39	medium_impact	2.26	0.48	damaging	0.12	damaging	3.33	22.90	deleterious	0.27	0.55	0.47	neutral	0.8	disease	0.53	disease	0.51	disease	0	0.97	neutral	0.5	deleterious	1	deleterious	0.32	neutral	0.66	medium_impact	-0.65	medium_impact	0.99	medium_impact	0.63	0.9	2.92	11.88	0.52	P	0.50	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13691	13691	A	C	MI.22150	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1355	452	N	T	aAc/aCc	3.83	0.78	0	possibly_damaging	0.88	neutral	0.4	neutral	0.76	neutral	-2.21	deleterious	-5.01	medium_impact	3.4	0.75	neutral	0.6	neutral	3.17	22.70	deleterious	0.5	0.6	0.54	disease	0.81	disease	0.62	disease	0.65	disease	3	0.88	neutral	0.26	neutral	0	NA	0.68	deleterious	-1.57	low_impact	0.14	medium_impact	1.9	medium_impact	0.58	0.8	4.48	7.21	0.38	N	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13691	13691	A	G	MI.22151	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1355	452	N	S	aAc/aGc	3.83	0.78	0	possibly_damaging	0.74	neutral	0.41	neutral	0.83	neutral	-1.21	deleterious	-4.06	medium_impact	2.5	0.78	neutral	0.69	neutral	1.48	13.20	neutral	0.65	0.7	0.66	disease	0.73	disease	0.53	disease	0.55	disease	1	0.75	neutral	0.34	neutral	0	NA	0.64	deleterious	-1.18	low_impact	0.15	medium_impact	1.08	medium_impact	0.40	0.8	4.48	7.21	0.32	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13692	13692	C	A	MI.22152	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1356	452	N	K	aaC/aaA	2.46	0.76	0	benign	0.12	neutral	0.3	neutral	0.86	neutral	-0.9	deleterious	-4.83	medium_impact	2.2	0.8	neutral	0.6	neutral	1.59	13.79	neutral	0.73	0.75	0.76	disease	0.81	disease	0.53	disease	0.58	disease	2	0.65	neutral	0.59	deleterious	-3	neutral	0.31	neutral	0.08	medium_impact	0.03	medium_impact	0.81	medium_impact	0.55	0.8	4.48	7.21	0.3	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13692	13692	C	G	MI.22153	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1356	452	N	K	aaC/aaG	2.46	0.76	0	benign	0.12	neutral	0.3	neutral	0.86	neutral	-0.9	deleterious	-4.83	medium_impact	2.2	0.8	neutral	0.6	neutral	1.16	11.51	neutral	0.73	0.75	0.76	disease	0.81	disease	0.53	disease	0.58	disease	2	0.65	neutral	0.59	deleterious	-3	neutral	0.31	neutral	0.08	medium_impact	0.03	medium_impact	0.81	medium_impact	0.55	0.8	4.48	7.21	0.3	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13693	13693	C	T	MI.22154	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1357	453	P	S	Ccc/Tcc	-2.35	0	0	possibly_damaging	0.66	neutral	0.42	neutral	0.64	neutral	-1.2	neutral	-2.44	low_impact	1.75	0.8	neutral	0.95	neutral	2.59	20.10	deleterious	0.44	0.55	0.53	disease	0.64	disease	0.43	neutral	0.48	neutral	0	0.68	neutral	0.38	neutral	-3	neutral	0.78	deleterious	-1.02	low_impact	0.16	medium_impact	0.4	medium_impact	0.43	0.8	11.28	14.66	0.28	N	0.07	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13693	13693	C	A	MI.22155	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1357	453	P	T	Ccc/Acc	-2.35	0	0	probably_damaging	0.94	neutral	0.4	neutral	0.35	deleterious	-3.73	deleterious	-3.41	medium_impact	2.88	0.63	neutral	0.23	damaging	3.97	23.60	deleterious	0.29	0.45	0.71	disease	0.8	disease	0.61	disease	0.68	disease	4	0.94	neutral	0.23	neutral	1	deleterious	0.81	deleterious	-1.88	low_impact	0.14	medium_impact	1.43	medium_impact	0.80	0.85	11.28	14.66	0.23	N	0.67	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13693	13693	C	G	MI.22156	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1357	453	P	A	Ccc/Gcc	-2.35	0	0	possibly_damaging	0.9	neutral	0.52	neutral	0.42	neutral	-2.72	deleterious	-3.01	medium_impact	2.58	0.7	neutral	0.64	neutral	3.17	22.70	deleterious	0.24	0.45	0.53	disease	0.57	disease	0.62	disease	0.49	neutral	0	0.89	neutral	0.31	neutral	0	NA	0.76	deleterious	-1.65	low_impact	0.25	medium_impact	1.15	medium_impact	0.77	0.85	11.28	14.66	0.28	N	0.75	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13694	13694	C	G	MI.22157	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1358	453	P	R	cCc/cGc	-0.06	0	0	probably_damaging	0.98	neutral	0.36	neutral	0.3	deleterious	-5.76	deleterious	-4.6	high_impact	3.78	0.61	neutral	0.14	damaging	3.73	23.30	deleterious	0.19	0.45	0.82	disease	0.85	disease	0.8	disease	0.83	disease	7	0.99	deleterious	0.19	neutral	2	deleterious	0.86	deleterious	-2.35	low_impact	0.1	medium_impact	2.25	high_impact	0.66	0.8	11.28	14.66	0.39	N	0.93	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13694	13694	C	T	MI.22158	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1358	453	P	L	cCc/cTc	-0.06	0	0	probably_damaging	0.98	neutral	0.69	neutral	0.3	deleterious	-5.75	deleterious	-5.4	high_impact	3.78	0.61	neutral	0.17	damaging	4.54	24.30	deleterious	0.34	0.5	0.68	disease	0.84	disease	0.67	disease	0.73	disease	5	0.98	deleterious	0.36	neutral	2	deleterious	0.81	deleterious	-2.35	low_impact	0.42	medium_impact	2.25	high_impact	0.78	0.85	11.28	14.66	0.25	N	0.97	polymorphism	1	0.29	.	.	.	.	.	.	COSM6716783	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13694	13694	C	A	MI.22159	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1358	453	P	H	cCc/cAc	-0.06	0	0	probably_damaging	1	neutral	0.54	neutral	0.29	deleterious	-6.75	deleterious	-4.69	high_impact	3.78	0.62	neutral	0.16	damaging	4.16	23.80	deleterious	0.23	0.45	0.89	disease	0.83	disease	0.79	disease	0.86	disease	7	0.99	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.27	medium_impact	2.25	high_impact	0.72	0.85	11.28	14.66	0.38	N	0.86	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6064	6064	A	G	MI.2216	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	161	54	Y	C	tAc/tGc	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	1.99	deleterious	-8.2	deleterious	-5.59	high_impact	5.08	0.5	damaging	0.03	damaging	3.42	23.00	deleterious	0.24	0.55	0.95	disease	0.91	disease	0.78	disease	0.88	disease	8	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.35	low_impact	-1.48	low_impact	3.59	high_impact	0.21	0.9	2.92	11.88	0.6	P	0.89	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13696	13696	A	T	MI.22160	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1360	454	I	F	Att/Ttt	-20	0	0	possibly_damaging	0.77	neutral	0.72	neutral	0.6	deleterious	-3.73	deleterious	-3.46	medium_impact	3.08	0.66	neutral	0.36	neutral	4.14	23.80	deleterious	0.34	0.5	0.7	disease	0.83	disease	0.64	disease	0.71	disease	4	0.72	neutral	0.48	deleterious	0	NA	0.80	deleterious	-1.24	low_impact	0.46	medium_impact	1.61	medium_impact	0.79	0.85	7.46	13.31	0.22	N	0.96	polymorphism	0.71	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13696	13696	A	G	MI.22161	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1360	454	I	V	Att/Gtt	-20	0	0	benign	0.42	neutral	0.54	neutral	0.73	neutral	-1.5	neutral	-0.81	medium_impact	3.28	0.82	neutral	0.66	neutral	3.14	22.60	deleterious	0.57	0.65	0.52	disease	0.49	neutral	0.5	neutral	0.45	neutral	1	0.42	neutral	0.56	deleterious	-3	neutral	0.66	deleterious	-0.61	medium_impact	0.27	medium_impact	1.79	medium_impact	0.63	0.8	7.46	13.31	0.29	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13696	13696	A	C	MI.22162	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1360	454	I	L	Att/Ctt	-20	0	0	benign	0.03	neutral	0.82	neutral	0.86	neutral	-0.64	neutral	-1.66	low_impact	0.97	0.81	neutral	0.74	neutral	2.80	21.40	deleterious	0.36	0.5	0.35	neutral	0.34	neutral	0.26	neutral	0.44	neutral	1	0.12	neutral	0.9	deleterious	-6	neutral	0.65	deleterious	0.69	medium_impact	0.6	medium_impact	-0.32	medium_impact	0.80	0.85	7.46	13.31	0.32	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13697	13697	T	A	MI.22163	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1361	454	I	N	aTt/aAt	2.23	0.96	0	probably_damaging	0.95	neutral	0.34	neutral	0.58	deleterious	-5.33	deleterious	-5.97	high_impact	3.62	0.66	neutral	0.43	neutral	4.51	24.30	deleterious	0.22	0.45	0.89	disease	0.9	disease	0.62	disease	0.8	disease	6	0.96	neutral	0.2	neutral	2	deleterious	0.86	deleterious	-1.96	low_impact	0.07	medium_impact	2.1	high_impact	0.70	0.85	7.46	13.31	0.45	N	0.99	disease_causing	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13697	13697	T	G	MI.22164	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1361	454	I	S	aTt/aGt	2.23	0.96	0	possibly_damaging	0.86	neutral	0.47	neutral	0.6	deleterious	-3.62	deleterious	-5.07	high_impact	3.62	0.7	neutral	0.49	neutral	4.41	24.10	deleterious	0.21	0.45	0.67	disease	0.9	disease	0.62	disease	0.74	disease	5	0.85	neutral	0.31	neutral	1	deleterious	0.83	deleterious	-1.5	low_impact	0.2	medium_impact	2.1	high_impact	0.59	0.8	7.46	13.31	0.46	N	0.96	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13697	13697	T	C	MI.22165	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1361	454	I	T	aTt/aCt	2.23	0.96	0	possibly_damaging	0.79	neutral	0.45	neutral	0.61	deleterious	-3.37	deleterious	-4.06	high_impact	3.62	0.69	neutral	0.47	neutral	3.46	23.00	deleterious	0.27	0.45	0.68	disease	0.8	disease	0.52	disease	0.63	disease	3	0.78	neutral	0.33	neutral	1	deleterious	0.80	deleterious	-1.29	low_impact	0.18	medium_impact	2.1	high_impact	0.64	0.8	7.46	13.31	0.44	N	0.96	disease_causing	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13698	13698	T	G	MI.22166	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1362	454	I	M	atT/atG	5.67	0.99	0	benign	0.15	neutral	0.28	neutral	0.91	neutral	-0.38	deleterious	-2.52	medium_impact	2.42	0.75	neutral	0.5	neutral	3.48	23.10	deleterious	0.57	0.65	0.36	neutral	0.68	disease	0.44	neutral	0.51	disease	0	0.67	neutral	0.57	deleterious	-3	neutral	0.69	deleterious	-0.03	medium_impact	0.01	medium_impact	1.01	medium_impact	0.84	0.9	7.46	13.31	0.59	P	0.76	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13698	13698	T	A	MI.22167	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1362	454	I	M	atT/atA	5.67	0.99	0	benign	0.15	neutral	0.28	neutral	0.91	neutral	-0.38	deleterious	-2.52	medium_impact	2.42	0.75	neutral	0.5	neutral	3.72	23.30	deleterious	0.57	0.65	0.36	neutral	0.68	disease	0.44	neutral	0.51	disease	0	0.67	neutral	0.57	deleterious	-3	neutral	0.69	deleterious	-0.03	medium_impact	0.01	medium_impact	1.01	medium_impact	0.84	0.9	7.46	13.31	0.59	P	0.76	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13699	13699	A	G	MI.22168	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1363	455	K	E	Aaa/Gaa	-4.64	0	0	possibly_damaging	0.62	neutral	0.27	neutral	0.84	neutral	-0.31	deleterious	-3.15	medium_impact	2.8	0.74	neutral	0.53	neutral	4.15	23.80	deleterious	0.44	0.55	0.61	disease	0.8	disease	0.64	disease	0.7	disease	4	0.75	neutral	0.33	neutral	0	NA	0.81	deleterious	-0.95	medium_impact	-0.01	medium_impact	1.36	medium_impact	0.75	0.85	23.55	18.35	0.31	N	0.79	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13699	13699	A	C	MI.22169	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1363	455	K	Q	Aaa/Caa	-4.64	0	0	possibly_damaging	0.86	neutral	0.29	neutral	0.84	neutral	-0.96	deleterious	-3.13	medium_impact	2.6	0.78	neutral	0.51	neutral	3.57	23.10	deleterious	0.51	0.6	0.72	disease	0.71	disease	0.56	disease	0.62	disease	2	0.89	neutral	0.22	neutral	0	NA	0.79	deleterious	-1.5	low_impact	0.02	medium_impact	1.17	medium_impact	0.78	0.85	23.55	18.35	0.27	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6064	6064	A	C	MI.2217	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	161	54	Y	S	tAc/tCc	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	1.99	deleterious	-7.81	deleterious	-5.59	high_impact	5.08	0.58	damaging	0.04	damaging	3.59	23.20	deleterious	0.2	0.55	0.87	disease	0.9	disease	0.76	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.35	low_impact	-1.48	low_impact	3.59	high_impact	0.33	0.9	2.92	11.88	0.64	P	0.90	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13700	13700	A	C	MI.22170	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1364	455	K	T	aAa/aCa	3.61	0.79	0	possibly_damaging	0.66	neutral	0.44	neutral	0.94	neutral	0.71	deleterious	-4.61	low_impact	1.37	0.83	neutral	0.7	neutral	3.69	23.30	deleterious	0.23	0.45	0.51	disease	0.5	neutral	0.3	neutral	0.46	neutral	1	0.66	neutral	0.39	neutral	-3	neutral	0.73	deleterious	-1.02	low_impact	0.18	medium_impact	0.05	medium_impact	0.56	0.8	23.55	18.35	0.31	N	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13700	13700	A	T	MI.22171	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1364	455	K	M	aAa/aTa	3.61	0.79	0	probably_damaging	0.98	neutral	0.31	neutral	0.89	neutral	0.9	deleterious	-4.82	low_impact	1.45	0.85	neutral	0.74	neutral	2.99	22.20	deleterious	0.26	0.45	0.56	disease	0.6	disease	0.29	neutral	0.49	neutral	0	0.98	neutral	0.17	neutral	-2	neutral	0.73	deleterious	-2.35	low_impact	0.04	medium_impact	0.12	medium_impact	0.59	0.8	23.55	18.35	0.32	N	0.52	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13701	13701	A	T	MI.22172	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1365	455	K	N	aaA/aaT	1.31	0.77	0	benign	0.05	neutral	0.35	neutral	0.84	neutral	-1.22	deleterious	-3.62	medium_impact	2.8	0.84	neutral	0.64	neutral	4.01	23.60	deleterious	0.52	0.6	0.67	disease	0.71	disease	0.56	disease	0.62	disease	2	0.62	neutral	0.65	deleterious	-3	neutral	0.80	deleterious	0.47	medium_impact	0.08	medium_impact	1.36	medium_impact	0.78	0.85	23.55	18.35	0.28	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13701	13701	A	C	MI.22173	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1365	455	K	N	aaA/aaC	1.31	0.77	0	benign	0.05	neutral	0.35	neutral	0.84	neutral	-1.22	deleterious	-3.62	medium_impact	2.8	0.84	neutral	0.64	neutral	3.95	23.60	deleterious	0.52	0.6	0.67	disease	0.71	disease	0.56	disease	0.62	disease	2	0.62	neutral	0.65	deleterious	-3	neutral	0.80	deleterious	0.47	medium_impact	0.08	medium_impact	1.36	medium_impact	0.78	0.85	23.55	18.35	0.28	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13702	13702	C	A	MI.22174	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1366	456	R	S	Cgc/Agc	0.17	0.74	0	probably_damaging	1	neutral	0.47	neutral	0.72	neutral	0.01	deleterious	-5.38	high_impact	3.56	0.59	damaging	0.33	neutral	4.80	24.80	deleterious	0.32	0.5	0.57	disease	0.88	disease	0.72	disease	0.78	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.2	medium_impact	2.05	high_impact	0.60	0.8	26.2	7.33	0.29	N	0.82	disease_causing	0.73	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13702	13702	C	T	MI.22175	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1366	456	R	C	Cgc/Tgc	0.17	0.74	0	probably_damaging	1	neutral	0.18	neutral	0.68	neutral	-1.28	deleterious	-7.18	high_impact	3.92	0.61	neutral	0.18	damaging	5.10	25.30	deleterious	0.37	0.5	0.73	disease	0.9	disease	0.77	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	-0.13	medium_impact	2.38	high_impact	0.76	0.85	26.2	7.33	0.4	N	1.00	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13702	13702	C	G	MI.22176	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1366	456	R	G	Cgc/Ggc	0.17	0.74	0	probably_damaging	1	neutral	0.4	neutral	0.77	neutral	-0.31	deleterious	-6.28	medium_impact	3.37	0.54	damaging	0.34	neutral	4.32	24.00	deleterious	0.33	0.5	0.64	disease	0.8	disease	0.75	disease	0.75	disease	5	1	deleterious	0.2	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.14	medium_impact	1.88	medium_impact	0.55	0.8	26.2	7.33	0.32	N	0.97	disease_causing	0.72	0.10	rs2853813	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13703	13703	G	C	MI.22177	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1367	456	R	P	cGc/cCc	3.38	1	0	probably_damaging	1	neutral	0.26	neutral	0.68	neutral	-1.16	deleterious	-6.28	high_impact	3.92	0.55	damaging	0.25	damaging	4.34	24.00	deleterious	0.23	0.45	0.63	disease	0.92	disease	0.81	disease	0.84	disease	7	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.02	medium_impact	2.38	high_impact	0.48	0.8	26.2	7.33	0.53	P	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13703	13703	G	T	MI.22178	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1367	456	R	L	cGc/cTc	3.38	1	0	probably_damaging	1	neutral	0.9	neutral	0.82	neutral	1.86	deleterious	-6.29	high_impact	3.56	0.56	damaging	0.32	neutral	4.44	24.20	deleterious	0.38	0.5	0.3	neutral	0.91	disease	0.73	disease	0.64	disease	3	1	deleterious	0.45	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.76	medium_impact	2.05	high_impact	0.56	0.8	26.2	7.33	0.44	N	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13703	13703	G	A	MI.22179	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1367	456	R	H	cGc/cAc	3.38	1	0	probably_damaging	1	neutral	0.53	neutral	0.68	neutral	-2.01	deleterious	-4.49	high_impact	3.92	0.54	damaging	0.21	damaging	4.64	24.50	deleterious	0.47	0.55	0.87	disease	0.85	disease	0.77	disease	0.83	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.26	medium_impact	2.38	high_impact	0.84	0.9	26.2	7.33	0.55	P	1.00	disease_causing	1	0.23	.	.	.	.	.	.	COSM1497295	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6066	6066	A	G	MI.2218	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	163	55	N	D	Aac/Gac	-3.81	0	0	benign	0.34	deleterious	0	neutral	2.68	neutral	2.15	deleterious	-3.14	high_impact	4.62	0.45	damaging	0.14	damaging	3.63	23.20	deleterious	0.4	0.55	0.88	disease	0.87	disease	0.75	disease	0.84	disease	7	1	deleterious	0.33	neutral	2	deleterious	0.52	deleterious	-0.49	medium_impact	-1.48	low_impact	3.17	high_impact	0.62	0.9	3.12	7.34	0.51	N	0.92	polymorphism	0.96	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13705	13705	C	G	MI.22180	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1369	457	L	V	Ctg/Gtg	-10.15	0	0	probably_damaging	1	neutral	0.5	neutral	-0.95	deleterious	-6.21	deleterious	-2.7	high_impact	3.94	0.33	damaging	0.04	damaging	3.53	23.10	deleterious	0.45	0.55	0.75	disease	0.7	disease	0.68	disease	0.69	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.23	medium_impact	2.4	high_impact	0.84	0.9	28.52	7.2	0.34	N	0.81	polymorphism	0.81	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13705	13705	C	A	MI.22181	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1369	457	L	M	Ctg/Atg	-10.15	0	0	probably_damaging	1	neutral	0.31	neutral	-0.91	deleterious	-5.47	neutral	-1.8	high_impact	3.94	0.4	damaging	0.05	damaging	3.87	23.50	deleterious	0.34	0.5	0.88	disease	0.7	disease	0.67	disease	0.75	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.04	medium_impact	2.4	high_impact	0.76	0.85	28.52	7.2	0.34	N	0.89	polymorphism	0.85	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13706	13706	T	A	MI.22182	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1370	457	L	Q	cTg/cAg	-0.52	0	0	probably_damaging	1	neutral	0.3	neutral	-1	deleterious	-9.41	deleterious	-5.39	high_impact	3.94	0.37	damaging	0.03	damaging	4.30	24.00	deleterious	0.15	0.4	0.88	disease	0.88	disease	0.69	disease	0.79	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.03	medium_impact	2.4	high_impact	0.71	0.85	28.52	7.2	0.41	N	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13706	13706	T	C	MI.22183	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1370	457	L	P	cTg/cCg	-0.52	0	0	probably_damaging	1	neutral	0.27	neutral	-1	deleterious	-9.98	deleterious	-6.29	high_impact	3.94	0.34	damaging	0.04	damaging	4.01	23.60	deleterious	0.15	0.4	0.88	disease	0.86	disease	0.8	disease	0.85	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	-0.01	medium_impact	2.4	high_impact	0.66	0.8	28.52	7.2	0.48	N	0.99	disease_causing	0.99	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13706	13706	T	G	MI.22184	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1370	457	L	R	cTg/cGg	-0.52	0	0	probably_damaging	1	neutral	0.43	neutral	-1	deleterious	-9.58	deleterious	-5.39	high_impact	3.94	0.41	damaging	0.04	damaging	4.30	24.00	deleterious	0.13	0.4	0.93	disease	0.91	disease	0.79	disease	0.88	disease	8	1	deleterious	0.22	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.17	medium_impact	2.4	high_impact	0.46	0.8	28.52	7.2	0.44	N	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13708	13708	G	T	MI.22185	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1372	458	A	S	Gca/Tca	-11.75	0	0.21	benign	0.4	neutral	0.5	neutral	0.73	neutral	-2.8	neutral	-1.51	medium_impact	2.96	0.54	damaging	0.7	neutral	1.87	15.43	deleterious	0.37	0.5	0.74	disease	0.82	disease	0.45	neutral	0.58	disease	2	0.44	neutral	0.55	deleterious	-3	neutral	0.26	neutral	-0.58	medium_impact	0.23	medium_impact	1.5	medium_impact	0.72	0.85	24.54	22.73	0.34	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13708	13708	G	A	MI.22186	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1372	458	A	T	Gca/Aca	-11.75	0	0.21	benign	0.02	neutral	0.48	neutral	0.67	deleterious	-3.04	neutral	-1.5	low_impact	1.48	0.29	damaging	0.74	neutral	1.25	12.03	neutral	0.37	0.5	0.63	disease	0.73	disease	0.44	neutral	0.53	disease	1	0.5	neutral	0.73	deleterious	-6	neutral	0.21	neutral	0.86	medium_impact	0.21	medium_impact	0.15	medium_impact	0.68	0.85	24.54	22.73	0.76	P	0.01	polymorphism	1	0.03	rs28359178	Conflicting_interpretations_of_pathogenicity	Leber's_optic_atrophy	24735	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	acute leukemia platelets, leukocytes & bone marrow, breast tumor	.	.	.	G13708A	LHON / Increased MS risk / higher freq in PD-ADS	+	-	Conflicting reports / population marker	47	N	N	N	neutral
chrM	13708	13708	G	C	MI.22187	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1372	458	A	P	Gca/Cca	-11.75	0	0.21	possibly_damaging	0.86	neutral	0.26	neutral	0.62	deleterious	-5.29	deleterious	-2.87	high_impact	3.65	0.54	damaging	0.4	neutral	2.05	16.53	deleterious	0.11	0.4	0.84	disease	0.94	disease	0.69	disease	0.78	disease	6	0.89	neutral	0.2	neutral	1	deleterious	0.38	neutral	-1.5	low_impact	-0.02	medium_impact	2.13	high_impact	0.74	0.85	24.54	22.73	0.33	N	0.62	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13709	13709	C	T	MI.22188	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1373	458	A	V	gCa/gTa	0.4	0	0	benign	0.4	neutral	0.56	neutral	0.74	neutral	-2.26	neutral	-0.74	medium_impact	2.85	0.51	damaging	0.67	neutral	2.62	20.30	deleterious	0.37	0.5	0.47	neutral	0.86	disease	0.45	neutral	0.66	disease	3	0.39	neutral	0.58	deleterious	-3	neutral	0.21	neutral	-0.58	medium_impact	0.29	medium_impact	1.4	medium_impact	0.73	0.85	24.54	22.73	0.43	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13709	13709	C	A	MI.22189	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1373	458	A	E	gCa/gAa	0.4	0	0	possibly_damaging	0.73	neutral	0.37	neutral	0.63	deleterious	-4.46	deleterious	-2.87	high_impact	3.65	0.56	damaging	0.5	neutral	2.60	20.20	deleterious	0.14	0.4	0.89	disease	0.92	disease	0.67	disease	0.81	disease	6	0.75	neutral	0.32	neutral	1	deleterious	0.32	neutral	-1.16	low_impact	0.11	medium_impact	2.13	high_impact	0.59	0.8	24.54	22.73	0.32	N	0.57	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6066	6066	A	C	MI.2219	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	163	55	N	H	Aac/Cac	-3.81	0	0	probably_damaging	0.93	deleterious	0	neutral	2.57	neutral	-1.91	deleterious	-3.14	high_impact	4.62	0.52	damaging	0.08	damaging	2.89	21.80	deleterious	0.25	0.55	0.81	disease	0.9	disease	0.66	disease	0.77	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.86	deleterious	-1.81	low_impact	-1.48	low_impact	3.17	high_impact	0.61	0.9	3.12	7.34	0.42	N	0.83	polymorphism	0.92	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13709	13709	C	G	MI.22190	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1373	458	A	G	gCa/gGa	0.4	0	0	possibly_damaging	0.61	neutral	0.41	neutral	0.67	deleterious	-3.26	deleterious	-2.92	medium_impact	3.31	0.55	damaging	0.61	neutral	2.11	16.95	deleterious	0.25	0.45	0.75	disease	0.81	disease	0.54	disease	0.58	disease	2	0.64	neutral	0.4	neutral	0	NA	0.23	neutral	-0.93	medium_impact	0.15	medium_impact	1.82	medium_impact	0.75	0.85	24.54	22.73	0.34	N	0.50	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13711	13711	G	A	MI.22191	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1375	459	A	T	Gcc/Acc	-6.25	0	0	benign	0.02	neutral	0.42	neutral	0.97	neutral	-0.52	neutral	-0.38	neutral_impact	-0.3	0.88	neutral	0.81	neutral	1.23	11.90	neutral	0.55	0.6	0.62	disease	0.39	neutral	0.35	neutral	0.61	disease	2	0.56	neutral	0.7	deleterious	-6	neutral	0.18	neutral	0.86	medium_impact	0.16	medium_impact	-1.48	low_impact	0.73	0.85	21.06	13.68	0.3	N	0.06	polymorphism	1	0.01	rs879489195	.	.	.	.	.	COSM1132235	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13711	13711	G	T	MI.22192	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1375	459	A	S	Gcc/Tcc	-6.25	0	0	benign	0.18	neutral	0.45	neutral	0.96	neutral	-0.61	neutral	-0.96	neutral_impact	0.7	0.82	neutral	0.77	neutral	1.93	15.77	deleterious	0.41	0.5	0.67	disease	0.51	disease	0.43	neutral	0.5	neutral	0	0.46	neutral	0.64	deleterious	-6	neutral	0.30	neutral	-0.12	medium_impact	0.18	medium_impact	-0.56	medium_impact	0.88	0.9	21.06	13.68	0.29	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13711	13711	G	C	MI.22193	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1375	459	A	P	Gcc/Ccc	-6.25	0	0	possibly_damaging	0.62	neutral	0.28	neutral	0.9	neutral	-2.8	neutral	-1.97	low_impact	1.24	0.66	neutral	0.4	neutral	3.53	23.10	deleterious	0.13	0.4	0.87	disease	0.88	disease	0.6	disease	0.84	disease	7	0.74	neutral	0.33	neutral	-3	neutral	0.66	deleterious	-0.95	medium_impact	0.01	medium_impact	-0.07	medium_impact	0.84	0.9	21.06	13.68	0.27	N	0.36	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13712	13712	C	G	MI.22194	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1376	459	A	G	gCc/gGc	-3.96	0	0	benign	0.24	neutral	0.38	neutral	0.91	neutral	-2.26	deleterious	-2.56	low_impact	1.24	0.77	neutral	0.74	neutral	2.21	17.55	deleterious	0.24	0.45	0.53	disease	0.52	disease	0.45	neutral	0.5	neutral	0	0.54	neutral	0.57	deleterious	-6	neutral	0.31	neutral	-0.27	medium_impact	0.12	medium_impact	-0.07	medium_impact	0.76	0.85	21.06	13.68	0.3	N	0.34	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13712	13712	C	T	MI.22195	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1376	459	A	V	gCc/gTc	-3.96	0	0	benign	0.01	neutral	0.57	neutral	1.04	neutral	0.42	neutral	1.72	neutral_impact	-0.83	0.89	neutral	0.97	neutral	1.08	11.09	neutral	0.41	0.5	0.33	neutral	0.51	disease	0.25	neutral	0.44	neutral	1	0.42	neutral	0.78	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.3	medium_impact	-1.96	low_impact	0.73	0.85	21.06	13.68	0.26	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13712	13712	C	A	MI.22196	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1376	459	A	D	gCc/gAc	-3.96	0	0	possibly_damaging	0.55	neutral	0.22	neutral	0.9	deleterious	-3.4	deleterious	-2.51	low_impact	1.24	0.65	neutral	0.47	neutral	2.96	22.10	deleterious	0.13	0.4	0.91	disease	0.83	disease	0.6	disease	0.84	disease	7	0.77	neutral	0.34	neutral	-3	neutral	0.54	deleterious	-0.83	medium_impact	-0.07	medium_impact	-0.07	medium_impact	0.73	0.85	21.06	13.68	0.27	N	0.37	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13714	13714	G	T	MI.22197	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1378	460	G	W	Gga/Tga	-13.12	0	0	probably_damaging	1	neutral	0.2	neutral	0.56	deleterious	-4.64	deleterious	-7.16	high_impact	3.82	0.46	damaging	0.24	damaging	4.55	24.30	deleterious	0.14	0.4	0.93	disease	0.94	disease	0.77	disease	0.88	disease	8	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.1	medium_impact	2.29	high_impact	0.51	0.8	11.77	7.47	0.39	N	1.00	polymorphism	0.98	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13714	13714	G	C	MI.22198	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1378	460	G	R	Gga/Cga	-13.12	0	0	probably_damaging	1	neutral	0.39	neutral	0.56	deleterious	-4.27	deleterious	-7.15	high_impact	3.82	0.44	damaging	0.25	damaging	4.09	23.70	deleterious	0.1	0.4	0.86	disease	0.94	disease	0.83	disease	0.91	disease	8	1	deleterious	0.2	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.13	medium_impact	2.29	high_impact	0.64	0.8	11.77	7.47	0.49	N	1.00	polymorphism	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13715	13715	G	T	MI.22199	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1379	460	G	V	gGa/gTa	5.9	1	0	probably_damaging	0.99	neutral	0.57	neutral	0.67	neutral	-2.02	deleterious	-8.05	high_impact	3.82	0.39	damaging	0.29	neutral	3.87	23.50	deleterious	0.15	0.45	0.52	disease	0.93	disease	0.75	disease	0.81	disease	6	0.98	deleterious	0.29	neutral	2	deleterious	0.84	deleterious	-2.64	low_impact	0.3	medium_impact	2.29	high_impact	0.59	0.8	11.77	7.47	0.71	P	0.98	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8631	8631	A	T	MI.222	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	105	35	K	N	aaA/aaT	-0.8	0	0	benign	0.01	neutral	0.43	neutral	4.35	neutral	-1.03	neutral	0.49	neutral_impact	-0.7	0.88	neutral	0.95	neutral	-0.98	0.02	neutral	0.65	0.7	0.34	neutral	0.14	neutral	0.25	neutral	0.22	neutral	6	0.56	neutral	0.71	deleterious	-6	neutral	0.14	neutral	1.14	medium_impact	0.22	medium_impact	-1.7	low_impact	0.60	0.9	20.35	18.29	0.46	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6066	6066	A	T	MI.2220	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	163	55	N	Y	Aac/Tac	-3.81	0	0	probably_damaging	0.99	deleterious	0	neutral	2.68	deleterious	-3.03	deleterious	-5.03	high_impact	4.47	0.52	damaging	0.1	damaging	3.44	23.00	deleterious	0.18	0.55	0.43	neutral	0.94	disease	0.62	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.64	low_impact	-1.48	low_impact	3.03	high_impact	0.57	0.9	3.12	7.34	0.38	N	0.93	polymorphism	0.73	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13715	13715	G	C	MI.22200	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1379	460	G	A	gGa/gCa	5.9	1	0	possibly_damaging	0.56	neutral	0.54	neutral	0.63	neutral	-2.56	deleterious	-5.36	medium_impact	2.12	0.53	damaging	0.63	neutral	3.23	22.80	deleterious	0.25	0.45	0.55	disease	0.77	disease	0.64	disease	0.53	disease	1	0.52	neutral	0.49	deleterious	0	NA	0.81	deleterious	-0.85	medium_impact	0.27	medium_impact	0.73	medium_impact	0.56	0.8	11.77	7.47	0.49	N	0.79	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13715	13715	G	A	MI.22201	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1379	460	G	E	gGa/gAa	5.9	1	0	probably_damaging	0.99	neutral	0.28	neutral	0.56	deleterious	-4.31	deleterious	-7.15	high_impact	3.82	0.43	damaging	0.28	damaging	4.00	23.60	deleterious	0.13	0.4	0.88	disease	0.93	disease	0.83	disease	0.88	disease	8	0.99	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-2.64	low_impact	0.01	medium_impact	2.29	high_impact	0.55	0.8	11.77	7.47	0.75	P	1.00	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13717	13717	A	C	MI.22202	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1381	461	S	R	Agc/Cgc	-1.44	0	0	probably_damaging	1	neutral	0.35	neutral	0.31	deleterious	-5.41	deleterious	-4.49	high_impact	3.88	0.6	neutral	0.41	neutral	4.04	23.70	deleterious	0.11	0.4	0.89	disease	0.93	disease	0.8	disease	0.9	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.08	medium_impact	2.34	high_impact	0.76	0.85	13.6	7.11	0.46	N	0.99	polymorphism	0.56	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13717	13717	A	G	MI.22203	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1381	461	S	G	Agc/Ggc	-1.44	0	0	probably_damaging	1	neutral	0.36	neutral	0.35	deleterious	-4.03	deleterious	-3.59	high_impact	3.88	0.59	damaging	0.53	neutral	3.75	23.30	deleterious	0.27	0.45	0.9	disease	0.8	disease	0.64	disease	0.77	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.1	medium_impact	2.34	high_impact	0.75	0.85	13.6	7.11	0.35	N	0.86	polymorphism	0.87	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13717	13717	A	T	MI.22204	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1381	461	S	C	Agc/Tgc	-1.44	0	0	probably_damaging	1	neutral	0.18	neutral	0.3	deleterious	-6.22	deleterious	-4.49	high_impact	3.88	0.61	neutral	0.41	neutral	3.65	23.20	deleterious	0.19	0.45	0.58	disease	0.89	disease	0.68	disease	0.75	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	-0.13	medium_impact	2.34	high_impact	0.81	0.85	13.6	7.11	0.37	N	0.99	polymorphism	0.6	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13718	13718	G	T	MI.22205	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1382	461	S	I	aGc/aTc	5.44	1	0	probably_damaging	1	neutral	0.44	neutral	0.31	deleterious	-5.43	deleterious	-5.39	high_impact	3.88	0.57	damaging	0.52	neutral	4.23	23.90	deleterious	0.17	0.45	0.55	disease	0.94	disease	0.7	disease	0.82	disease	6	1	deleterious	0.22	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.18	medium_impact	2.34	high_impact	0.84	0.9	13.6	7.11	0.51	N	0.99	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13718	13718	G	C	MI.22206	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1382	461	S	T	aGc/aCc	5.44	1	0	probably_damaging	1	neutral	0.4	neutral	0.45	neutral	-2.44	deleterious	-2.69	medium_impact	2.44	0.62	neutral	0.63	neutral	3.50	23.10	deleterious	0.29	0.45	0.56	disease	0.73	disease	0.62	disease	0.55	disease	1	1	deleterious	0.2	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.14	medium_impact	1.03	medium_impact	0.87	0.9	13.6	7.11	0.45	N	0.71	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13718	13718	G	A	MI.22207	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1382	461	S	N	aGc/aAc	5.44	1	0	probably_damaging	1	neutral	0.32	neutral	0.32	deleterious	-5.15	deleterious	-2.69	high_impact	3.88	0.55	damaging	0.45	neutral	3.80	23.40	deleterious	0.46	0.55	0.84	disease	0.88	disease	0.7	disease	0.78	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.05	medium_impact	2.34	high_impact	0.56	0.8	13.6	7.11	0.58	P	0.87	disease_causing	1	0.17	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13720	13720	C	A	MI.22208	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1384	462	L	M	Cta/Ata	-1.89	0	0	benign	0.29	neutral	0.26	neutral	0.81	neutral	-2.03	neutral	-0.9	neutral_impact	0.34	0.79	neutral	0.83	neutral	3.78	23.40	deleterious	0.35	0.5	0.79	disease	0.54	disease	0.3	neutral	0.57	disease	1	0.69	neutral	0.49	deleterious	-6	neutral	0.77	deleterious	-0.38	medium_impact	-0.02	medium_impact	-0.89	medium_impact	0.78	0.85	13.1	13.73	0.32	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13720	13720	C	G	MI.22209	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1384	462	L	V	Cta/Gta	-1.89	0	0	possibly_damaging	0.49	neutral	0.54	neutral	1.06	neutral	0.34	neutral	0.62	neutral_impact	0.03	0.83	neutral	0.95	neutral	3.48	23.10	deleterious	0.34	0.5	0.32	neutral	0.57	disease	0.31	neutral	0.44	neutral	1	0.47	neutral	0.53	deleterious	-3	neutral	0.70	deleterious	-0.73	medium_impact	0.27	medium_impact	-1.18	low_impact	0.70	0.85	13.1	13.73	0.25	N	0.11	polymorphism	0.99	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6067	6067	A	T	MI.2221	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	164	55	N	I	aAc/aTc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.55	neutral	-2.93	deleterious	-5.66	high_impact	4.82	0.52	damaging	0.09	damaging	3.82	23.40	deleterious	0.17	0.55	0.8	disease	0.95	disease	0.67	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.64	low_impact	-1.48	low_impact	3.35	high_impact	0.51	0.9	3.12	7.34	0.66	P	0.98	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13721	13721	T	A	MI.22210	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1385	462	L	Q	cTa/cAa	1.08	0.42	0	probably_damaging	0.96	neutral	0.29	neutral	0.76	deleterious	-5.16	deleterious	-4.49	low_impact	1.94	0.69	neutral	0.61	neutral	4.20	23.90	deleterious	0.18	0.45	0.88	disease	0.81	disease	0.57	disease	0.81	disease	6	0.97	neutral	0.17	neutral	-2	neutral	0.85	deleterious	-2.06	low_impact	0.02	medium_impact	0.57	medium_impact	0.74	0.85	13.1	13.73	0.29	N	0.77	polymorphism	0.98	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13721	13721	T	G	MI.22211	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1385	462	L	R	cTa/cGa	1.08	0.42	0	probably_damaging	0.95	neutral	0.42	neutral	0.76	deleterious	-5.06	deleterious	-4.52	low_impact	1.94	0.65	neutral	0.51	neutral	4.33	24.00	deleterious	0.15	0.4	0.87	disease	0.94	disease	0.7	disease	0.86	disease	7	0.95	neutral	0.24	neutral	-2	neutral	0.91	deleterious	-1.96	low_impact	0.16	medium_impact	0.57	medium_impact	0.64	0.8	13.1	13.73	0.27	N	0.78	polymorphism	0.98	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13721	13721	T	C	MI.22212	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1385	462	L	P	cTa/cCa	1.08	0.42	0	probably_damaging	0.98	neutral	0.23	neutral	0.75	deleterious	-5.38	deleterious	-4.59	low_impact	1.94	0.53	damaging	0.44	neutral	4.04	23.70	deleterious	0.17	0.45	0.9	disease	0.93	disease	0.71	disease	0.86	disease	7	0.98	deleterious	0.13	neutral	-2	neutral	0.93	deleterious	-2.35	low_impact	-0.06	medium_impact	0.57	medium_impact	0.68	0.85	13.1	13.73	0.31	N	0.88	disease_causing	1	0.27	.	.	.	.	.	.	COSM6716799	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13723	13723	T	G	MI.22213	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1387	463	F	V	Ttc/Gtc	-7.17	0	0	benign	0.01	neutral	0.54	neutral	1.04	neutral	0.27	deleterious	-4.04	low_impact	1.32	0.83	neutral	0.83	neutral	0.88	9.93	deleterious	0.3	0.45	0.45	neutral	0.62	disease	0.4	neutral	0.46	neutral	1	0.45	neutral	0.77	deleterious	-6	neutral	0.38	neutral	1.15	medium_impact	0.27	medium_impact	0	medium_impact	0.70	0.85	19.24	15.09	0.26	N	0.83	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13723	13723	T	A	MI.22214	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1387	463	F	I	Ttc/Atc	-7.17	0	0	benign	0.01	neutral	0.55	neutral	1.11	neutral	0.72	deleterious	-3.23	neutral_impact	0.26	0.81	neutral	0.9	neutral	0.59	8.09	deleterious	0.25	0.45	0.49	neutral	0.32	neutral	0.31	neutral	0.43	neutral	1	0.44	neutral	0.77	deleterious	-6	neutral	0.35	neutral	1.15	medium_impact	0.28	medium_impact	-0.97	medium_impact	0.67	0.85	19.24	15.09	0.27	N	0.37	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13723	13723	T	C	MI.22215	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1387	463	F	L	Ttc/Ctc	-7.17	0	0	benign	0.01	neutral	1	neutral	1.03	neutral	0.22	deleterious	-3.01	neutral_impact	0.32	0.85	neutral	0.95	neutral	0.33	5.99	deleterious	0.4	0.5	0.36	neutral	0.5	neutral	0.34	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	1.89	high_impact	-0.91	medium_impact	0.75	0.85	19.24	15.09	0.22	N	0.48	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13724	13724	T	A	MI.22216	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1388	463	F	Y	tTc/tAc	-0.75	0	0	possibly_damaging	0.61	neutral	0.84	neutral	0.84	neutral	-2.59	neutral	-2.13	medium_impact	2.89	0.75	neutral	0.49	neutral	4.19	23.80	deleterious	0.33	0.5	0.8	disease	0.72	disease	0.61	disease	0.74	disease	5	0.54	neutral	0.62	deleterious	0	NA	0.66	deleterious	-0.93	medium_impact	0.63	medium_impact	1.44	medium_impact	0.72	0.85	19.24	15.09	0.21	N	0.77	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13724	13724	T	C	MI.22217	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1388	463	F	S	tTc/tCc	-0.75	0	0	possibly_damaging	0.54	neutral	0.43	neutral	0.89	neutral	-1.23	deleterious	-5.51	medium_impact	2.54	0.84	neutral	0.59	neutral	4.26	23.90	deleterious	0.28	0.45	0.79	disease	0.75	disease	0.6	disease	0.72	disease	4	0.58	neutral	0.45	neutral	0	NA	0.72	deleterious	-0.81	medium_impact	0.17	medium_impact	1.12	medium_impact	0.65	0.8	19.24	15.09	0.26	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13724	13724	T	G	MI.22218	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1388	463	F	C	tTc/tGc	-0.75	0	0	probably_damaging	0.93	neutral	0.16	neutral	0.83	deleterious	-3.39	deleterious	-5.33	medium_impact	2.89	0.74	neutral	0.49	neutral	4.19	23.90	deleterious	0.27	0.45	0.89	disease	0.86	disease	0.63	disease	0.8	disease	6	0.96	neutral	0.12	neutral	1	deleterious	0.80	deleterious	-1.81	low_impact	-0.17	medium_impact	1.44	medium_impact	0.47	0.8	19.24	15.09	0.29	N	0.86	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13725	13725	C	A	MI.22219	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1389	463	F	L	ttC/ttA	3.61	0.34	0.04	benign	0.01	neutral	1	neutral	1.03	neutral	0.22	deleterious	-3.01	neutral_impact	0.32	0.85	neutral	0.95	neutral	0.98	10.54	neutral	0.4	0.5	0.36	neutral	0.5	neutral	0.34	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	1.89	high_impact	-0.91	medium_impact	0.75	0.85	19.24	15.09	0.29	N	0.48	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6067	6067	A	G	MI.2222	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	164	55	N	S	aAc/aGc	8.69	1	0	benign	0.16	deleterious	0	neutral	2.65	neutral	-0.53	deleterious	-3.14	high_impact	4.62	0.56	damaging	0.1	damaging	2.99	22.20	deleterious	0.47	0.55	0.81	disease	0.89	disease	0.67	disease	0.77	disease	5	1	deleterious	0.42	neutral	2	deleterious	0.51	deleterious	-0.08	medium_impact	-1.48	low_impact	3.17	high_impact	0.55	0.9	3.12	7.34	0.54	P	0.79	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13725	13725	C	G	MI.22220	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1389	463	F	L	ttC/ttG	3.61	0.34	0.04	benign	0.01	neutral	1	neutral	1.03	neutral	0.22	deleterious	-3.01	neutral_impact	0.32	0.85	neutral	0.95	neutral	0.65	8.47	deleterious	0.4	0.5	0.36	neutral	0.5	neutral	0.34	neutral	0.45	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	1.89	high_impact	-0.91	medium_impact	0.75	0.85	19.24	15.09	0.29	N	0.48	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13726	13726	G	T	MI.22221	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1390	464	A	S	Gca/Tca	-7.17	0	0	possibly_damaging	0.74	neutral	0.44	neutral	0.9	neutral	-0.45	neutral	-2.38	medium_impact	2.03	0.77	neutral	0.63	neutral	3.41	23.00	deleterious	0.45	0.55	0.7	disease	0.84	disease	0.43	neutral	0.56	disease	1	0.74	neutral	0.35	neutral	0	NA	0.61	deleterious	-1.18	low_impact	0.18	medium_impact	0.65	medium_impact	0.88	0.9	8.96	10.51	0.23	N	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13726	13726	G	C	MI.22222	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1390	464	A	P	Gca/Cca	-7.17	0	0	probably_damaging	0.97	neutral	0.21	neutral	0.62	deleterious	-4.54	deleterious	-4.19	high_impact	3.66	0.69	neutral	0.35	neutral	3.92	23.50	deleterious	0.12	0.4	0.89	disease	0.95	disease	0.76	disease	0.87	disease	7	0.98	neutral	0.12	neutral	2	deleterious	0.89	deleterious	-2.18	low_impact	-0.09	medium_impact	2.14	high_impact	0.81	0.85	8.96	10.51	0.34	N	0.93	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13726	13726	G	A	MI.22223	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1390	464	A	T	Gca/Aca	-7.17	0	0	benign	0.13	neutral	0.4	neutral	0.69	neutral	-2.29	deleterious	-3.27	medium_impact	2.03	0.77	neutral	0.68	neutral	2.38	18.72	deleterious	0.48	0.55	0.64	disease	0.84	disease	0.45	neutral	0.54	disease	1	0.53	neutral	0.64	deleterious	-3	neutral	0.30	neutral	0.04	medium_impact	0.14	medium_impact	0.65	medium_impact	0.74	0.85	8.96	10.51	0.24	N	0.51	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13727	13727	C	T	MI.22224	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1391	464	A	V	gCa/gTa	1.08	0.24	0	benign	0.12	neutral	0.52	neutral	0.64	deleterious	-3.53	deleterious	-3.26	medium_impact	2.56	0.73	neutral	0.65	neutral	4.22	23.90	deleterious	0.34	0.5	0.45	neutral	0.84	disease	0.59	disease	0.54	disease	1	0.39	neutral	0.7	deleterious	-3	neutral	0.60	deleterious	0.08	medium_impact	0.25	medium_impact	1.14	medium_impact	0.80	0.85	8.96	10.51	0.3	N	0.62	polymorphism	0.85	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13727	13727	C	A	MI.22225	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1391	464	A	E	gCa/gAa	1.08	0.24	0	possibly_damaging	0.88	neutral	0.27	neutral	0.64	deleterious	-3.45	deleterious	-4.17	high_impact	3.66	0.68	neutral	0.4	neutral	4.44	24.20	deleterious	0.11	0.4	0.88	disease	0.94	disease	0.74	disease	0.85	disease	7	0.9	neutral	0.2	neutral	1	deleterious	0.81	deleterious	-1.57	low_impact	-0.01	medium_impact	2.14	high_impact	0.77	0.85	8.96	10.51	0.4	N	0.91	polymorphism	0.76	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13727	13727	C	G	MI.22226	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1391	464	A	G	gCa/gGa	1.08	0.24	0	possibly_damaging	0.8	neutral	0.36	neutral	0.95	neutral	-0.2	deleterious	-3.34	medium_impact	2.56	0.75	neutral	0.65	neutral	3.77	23.40	deleterious	0.28	0.45	0.57	disease	0.85	disease	0.45	neutral	0.54	disease	1	0.82	neutral	0.28	neutral	0	NA	0.61	deleterious	-1.32	low_impact	0.1	medium_impact	1.14	medium_impact	0.71	0.85	8.96	10.51	0.28	N	0.70	polymorphism	0.88	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13729	13729	G	T	MI.22227	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1393	465	G	W	Gga/Tga	-6.71	0	0	probably_damaging	1	neutral	0.27	deleterious	-2.89	deleterious	-13.96	deleterious	-7.19	high_impact	3.94	0.27	damaging	0.02	damaging	4.54	24.30	deleterious	0.16	0.45	0.93	disease	0.93	disease	0.81	disease	0.88	disease	8	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.01	medium_impact	2.4	high_impact	0.33	0.8	23.55	7.09	0.48	P	1.00	disease_causing	0.95	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13729	13729	G	C	MI.22228	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1393	465	G	R	Gga/Cga	-6.71	0	0	probably_damaging	1	neutral	0.34	deleterious	-2.88	deleterious	-12.09	deleterious	-7.19	high_impact	3.94	0.3	damaging	0.02	damaging	4.08	23.70	deleterious	0.14	0.4	0.97	disease	0.93	disease	0.85	disease	0.86	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.92	deleterious	-3.6	low_impact	0.07	medium_impact	2.4	high_impact	0.68	0.85	23.55	7.09	0.45	N	1.00	disease_causing	0.92	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13730	13730	G	C	MI.22229	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1394	465	G	A	gGa/gCa	9.11	1	0	probably_damaging	1	neutral	0.54	deleterious	-2.87	deleterious	-10.35	deleterious	-5.39	high_impact	3.94	0.36	damaging	0.04	damaging	3.21	22.70	deleterious	0.25	0.45	0.84	disease	0.79	disease	0.74	disease	0.79	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.27	medium_impact	2.4	high_impact	0.49	0.8	23.55	7.09	0.59	P	0.79	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6067	6067	A	C	MI.2223	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	164	55	N	T	aAc/aCc	8.69	1	0	possibly_damaging	0.54	deleterious	0	neutral	2.59	neutral	-1.17	deleterious	-3.77	high_impact	5.17	0.54	damaging	0.1	damaging	3.26	22.80	deleterious	0.32	0.55	0.82	disease	0.91	disease	0.68	disease	0.77	disease	5	1	deleterious	0.23	neutral	5	deleterious	0.73	deleterious	-0.82	medium_impact	-1.48	low_impact	3.68	high_impact	0.60	0.9	3.12	7.34	0.68	P	0.59	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13730	13730	G	T	MI.22230	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1394	465	G	V	gGa/gTa	9.11	1	0	probably_damaging	1	neutral	0.55	deleterious	-2.88	deleterious	-12	deleterious	-8.09	high_impact	3.94	0.28	damaging	0.02	damaging	3.89	23.50	deleterious	0.16	0.45	0.94	disease	0.92	disease	0.79	disease	0.87	disease	7	1	deleterious	0.28	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.28	medium_impact	2.4	high_impact	0.50	0.8	23.55	7.09	0.67	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13730	13730	G	A	MI.22231	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1394	465	G	E	gGa/gAa	9.11	1	0	probably_damaging	1	neutral	0.27	deleterious	-2.88	deleterious	-11.67	deleterious	-7.19	high_impact	3.94	0.19	damaging	0.01	damaging	4.05	23.70	deleterious	0.17	0.45	0.96	disease	0.92	disease	0.85	disease	0.86	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.01	medium_impact	2.4	high_impact	0.59	0.8	23.55	7.09	0.83	P	1.00	disease_causing_automatic	1	0.51	rs387906425	Pathogenic	Leber's_optic_atrophy	24736	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	G13730A	LHON	-	+	Reported	7	P	P	P	damaging
chrM	13732	13732	T	A	MI.22232	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1396	466	F	I	Ttt/Att	-8.54	0	0	probably_damaging	1	neutral	0.4	neutral	0.96	neutral	-0.92	deleterious	-4.98	medium_impact	2.06	0.83	neutral	0.69	neutral	4.60	24.40	deleterious	0.27	0.45	0.39	neutral	0.7	disease	0.53	disease	0.61	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.14	medium_impact	0.68	medium_impact	0.55	0.8	5.47	11.56	0.32	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13732	13732	T	G	MI.22233	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1396	466	F	V	Ttt/Gtt	-8.54	0	0	probably_damaging	1	neutral	0.5	neutral	0.98	neutral	-0.77	deleterious	-5.67	medium_impact	2.68	0.84	neutral	0.61	neutral	4.28	24.00	deleterious	0.32	0.5	0.34	neutral	0.72	disease	0.62	disease	0.57	disease	1	1	deleterious	0.25	neutral	1	deleterious	0.67	deleterious	-3.6	low_impact	0.23	medium_impact	1.25	medium_impact	0.44	0.8	5.47	11.56	0.27	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13732	13732	T	C	MI.22234	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1396	466	F	L	Ttt/Ctt	-8.54	0	0	probably_damaging	1	neutral	0.65	neutral	1.1	neutral	-0.21	deleterious	-4.98	neutral_impact	0.38	0.74	neutral	0.82	neutral	2.00	16.20	deleterious	0.38	0.5	0.29	neutral	0.22	neutral	0.3	neutral	0.4	neutral	2	1	deleterious	0.33	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.38	medium_impact	-0.86	medium_impact	0.59	0.8	5.47	11.56	0.3	N	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13733	13733	T	A	MI.22235	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1397	466	F	Y	tTt/tAt	0.17	0	0	probably_damaging	1	neutral	1	neutral	0.9	neutral	-1.63	neutral	-1.25	low_impact	1.49	0.86	neutral	0.97	neutral	3.25	22.80	deleterious	0.4	0.5	0.6	disease	0.48	neutral	0.41	neutral	0.59	disease	2	1	deleterious	0.5	deleterious	-2	neutral	0.71	deleterious	-3.6	low_impact	1.89	high_impact	0.16	medium_impact	0.65	0.8	5.47	11.56	0.24	N	0.12	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13733	13733	T	C	MI.22236	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1397	466	F	S	tTt/tCt	0.17	0	0	probably_damaging	1	neutral	0.4	neutral	1.15	neutral	-1.98	deleterious	-6.57	low_impact	1.88	0.81	neutral	0.85	neutral	4.46	24.20	deleterious	0.33	0.5	0.55	disease	0.71	disease	0.61	disease	0.59	disease	2	1	deleterious	0.2	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.14	medium_impact	0.51	medium_impact	0.52	0.8	5.47	11.56	0.26	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13733	13733	T	G	MI.22237	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1397	466	F	C	tTt/tGt	0.17	0	0	probably_damaging	1	neutral	0.18	neutral	0.9	deleterious	-3.7	deleterious	-6.57	medium_impact	3.03	0.69	neutral	0.46	neutral	4.32	24.00	deleterious	0.23	0.45	0.69	disease	0.84	disease	0.64	disease	0.79	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.13	medium_impact	1.57	medium_impact	0.26	0.8	5.47	11.56	0.3	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13734	13734	T	G	MI.22238	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1398	466	F	L	ttT/ttG	1.31	0	0.02	probably_damaging	1	neutral	0.65	neutral	1.1	neutral	-0.21	deleterious	-4.98	neutral_impact	0.38	0.74	neutral	0.82	neutral	2.23	17.68	deleterious	0.38	0.5	0.29	neutral	0.22	neutral	0.3	neutral	0.4	neutral	2	1	deleterious	0.33	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.38	medium_impact	-0.86	medium_impact	0.59	0.8	5.47	11.56	0.3	N	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13734	13734	T	A	MI.22239	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1398	466	F	L	ttT/ttA	1.31	0	0.02	probably_damaging	1	neutral	0.65	neutral	1.1	neutral	-0.21	deleterious	-4.98	neutral_impact	0.38	0.74	neutral	0.82	neutral	2.35	18.52	deleterious	0.38	0.5	0.29	neutral	0.22	neutral	0.3	neutral	0.4	neutral	2	1	deleterious	0.33	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.38	medium_impact	-0.86	medium_impact	0.59	0.8	5.47	11.56	0.32	N	0.78	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6068	6068	C	A	MI.2224	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	165	55	N	K	aaC/aaA	8.69	1	0	benign	0.34	deleterious	0	neutral	2.61	neutral	-0.49	deleterious	-3.77	high_impact	4.82	0.43	damaging	0.12	damaging	4.36	24.10	deleterious	0.33	0.55	0.82	disease	0.93	disease	0.69	disease	0.78	disease	6	1	deleterious	0.33	neutral	2	deleterious	0.55	deleterious	-0.49	medium_impact	-1.48	low_impact	3.35	high_impact	0.73	0.9	3.12	7.34	0.73	P	0.92	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13735	13735	C	T	MI.22240	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1399	467	L	F	Ctc/Ttc	-3.96	0	0	benign	0.05	neutral	0.7	neutral	0.88	neutral	-0.83	neutral	-1.52	medium_impact	2.37	0.89	neutral	0.96	neutral	0.84	9.68	deleterious	0.43	0.55	0.56	disease	0.66	disease	0.42	neutral	0.5	disease	0	0.23	neutral	0.83	deleterious	-3	neutral	0.22	neutral	0.47	medium_impact	0.44	medium_impact	0.96	medium_impact	0.62	0.8	11.77	13.66	0.24	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13735	13735	C	A	MI.22241	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1399	467	L	I	Ctc/Atc	-3.96	0	0	benign	0.05	neutral	0.4	neutral	0.91	neutral	-0.58	neutral	-0.38	low_impact	0.92	0.83	neutral	0.99	neutral	0.08	3.39	deleterious	0.42	0.55	0.42	neutral	0.25	neutral	0.35	neutral	0.44	neutral	1	0.56	neutral	0.68	deleterious	-6	neutral	0.39	neutral	0.47	medium_impact	0.14	medium_impact	-0.36	medium_impact	0.66	0.8	11.77	13.66	0.41	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13735	13735	C	G	MI.22242	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1399	467	L	V	Ctc/Gtc	-3.96	0	0	benign	0.08	neutral	0.5	neutral	0.88	neutral	-0.78	neutral	-1.22	low_impact	1.75	0.85	neutral	0.94	neutral	0.71	8.87	deleterious	0.4	0.5	0.51	disease	0.5	disease	0.43	neutral	0.47	neutral	1	0.43	neutral	0.71	deleterious	-6	neutral	0.41	neutral	0.26	medium_impact	0.23	medium_impact	0.4	medium_impact	0.65	0.8	11.77	13.66	0.29	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13736	13736	T	G	MI.22243	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1400	467	L	R	cTc/cGc	-14.73	0	0	probably_damaging	0.92	neutral	0.35	neutral	0.73	deleterious	-3.71	deleterious	-4.54	medium_impact	3.41	0.65	neutral	0.44	neutral	4.22	23.90	deleterious	0.14	0.4	0.87	disease	0.89	disease	0.75	disease	0.85	disease	7	0.92	neutral	0.22	neutral	1	deleterious	0.86	deleterious	-1.75	low_impact	0.08	medium_impact	1.91	medium_impact	0.67	0.85	11.77	13.66	0.36	N	0.85	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13736	13736	T	A	MI.22244	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1400	467	L	H	cTc/cAc	-14.73	0	0	probably_damaging	0.96	neutral	0.54	neutral	0.72	deleterious	-4.24	deleterious	-4.72	medium_impact	3.41	0.71	neutral	0.5	neutral	4.10	23.70	deleterious	0.18	0.45	0.8	disease	0.81	disease	0.72	disease	0.77	disease	5	0.96	neutral	0.29	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	0.27	medium_impact	1.91	medium_impact	0.65	0.8	11.77	13.66	0.26	N	0.79	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13736	13736	T	C	MI.22245	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1400	467	L	P	cTc/cCc	-14.73	0	0	probably_damaging	0.94	neutral	0.2	neutral	0.72	deleterious	-4.29	deleterious	-5.16	medium_impact	3.41	0.58	damaging	0.4	neutral	3.96	23.60	deleterious	0.13	0.4	0.91	disease	0.89	disease	0.75	disease	0.84	disease	7	0.96	neutral	0.13	neutral	1	deleterious	0.88	deleterious	-1.88	low_impact	-0.1	medium_impact	1.91	medium_impact	0.47	0.8	11.77	13.66	0.34	N	0.91	polymorphism	0.79	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13738	13738	A	G	MI.22246	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1402	468	I	V	Att/Gtt	-6.94	0	0	probably_damaging	1	neutral	0.52	neutral	0.73	neutral	-2.21	neutral	-0.86	medium_impact	2.77	0.78	neutral	0.28	damaging	3.17	22.70	deleterious	0.63	0.65	0.62	disease	0.4	neutral	0.56	disease	0.61	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.65	deleterious	-3.6	low_impact	0.25	medium_impact	1.33	medium_impact	0.50	0.8	13.27	13.52	0.26	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13738	13738	A	C	MI.22247	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1402	468	I	L	Att/Ctt	-6.94	0	0	probably_damaging	1	neutral	0.94	neutral	1.36	neutral	1.21	neutral	-0.83	neutral_impact	0.43	0.8	neutral	0.92	neutral	2.33	18.38	deleterious	0.45	0.55	0.49	neutral	0.36	neutral	0.39	neutral	0.39	neutral	2	1	deleterious	0.47	deleterious	-2	neutral	0.65	deleterious	-3.6	low_impact	0.89	medium_impact	-0.81	medium_impact	0.72	0.85	13.27	13.52	0.24	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13738	13738	A	T	MI.22248	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1402	468	I	F	Att/Ttt	-6.94	0	0	probably_damaging	1	neutral	0.77	neutral	0.81	neutral	-1.17	deleterious	-3.06	medium_impact	2.34	0.77	neutral	0.17	damaging	3.89	23.50	deleterious	0.49	0.55	0.59	disease	0.76	disease	0.59	disease	0.57	disease	1	1	deleterious	0.39	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.52	medium_impact	0.94	medium_impact	0.74	0.85	13.27	13.52	0.15	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13739	13739	T	G	MI.22249	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1403	468	I	S	aTt/aGt	0.63	0.13	0	probably_damaging	1	neutral	0.57	neutral	0.67	deleterious	-4.42	deleterious	-4.83	medium_impact	3.31	0.73	neutral	0.14	damaging	4.39	24.10	deleterious	0.27	0.45	0.68	disease	0.85	disease	0.65	disease	0.74	disease	5	1	deleterious	0.29	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.3	medium_impact	1.82	medium_impact	0.56	0.8	13.27	13.52	0.25	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6068	6068	C	G	MI.2225	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	165	55	N	K	aaC/aaG	8.69	1	0	benign	0.34	deleterious	0	neutral	2.61	neutral	-0.49	deleterious	-3.77	high_impact	4.82	0.43	damaging	0.12	damaging	3.85	23.40	deleterious	0.33	0.55	0.82	disease	0.93	disease	0.69	disease	0.78	disease	6	1	deleterious	0.33	neutral	2	deleterious	0.55	deleterious	-0.49	medium_impact	-1.48	low_impact	3.35	high_impact	0.73	0.9	3.12	7.34	0.73	P	0.92	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13739	13739	T	A	MI.22250	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1403	468	I	N	aTt/aAt	0.63	0.13	0	probably_damaging	1	neutral	0.29	neutral	0.65	deleterious	-5.61	deleterious	-5.72	medium_impact	3.31	0.68	neutral	0.11	damaging	4.55	24.40	deleterious	0.3	0.45	0.71	disease	0.84	disease	0.67	disease	0.75	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.02	medium_impact	1.82	medium_impact	0.61	0.8	13.27	13.52	0.3	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13739	13739	T	C	MI.22251	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1403	468	I	T	aTt/aCt	0.63	0.13	0	probably_damaging	1	neutral	0.46	neutral	0.7	deleterious	-3	deleterious	-3.96	low_impact	1.87	0.76	neutral	0.18	damaging	3.50	23.10	deleterious	0.43	0.55	0.65	disease	0.68	disease	0.66	disease	0.54	disease	1	1	deleterious	0.23	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.19	medium_impact	0.51	medium_impact	0.63	0.8	13.27	13.52	0.24	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13740	13740	T	G	MI.22252	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1404	468	I	M	atT/atG	5.67	0.87	0	probably_damaging	1	neutral	0.29	neutral	0.77	neutral	-1.67	neutral	-1.81	medium_impact	2.12	0.82	neutral	0.77	neutral	2.45	19.12	deleterious	0.5	0.6	0.78	disease	0.56	disease	0.43	neutral	0.54	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.02	medium_impact	0.73	medium_impact	0.80	0.85	13.27	13.52	0.46	N	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13740	13740	T	A	MI.22253	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1404	468	I	M	atT/atA	5.67	0.87	0	probably_damaging	1	neutral	0.29	neutral	0.77	neutral	-1.67	neutral	-1.81	medium_impact	2.12	0.82	neutral	0.77	neutral	2.74	21.00	deleterious	0.5	0.6	0.78	disease	0.56	disease	0.43	neutral	0.54	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.02	medium_impact	0.73	medium_impact	0.80	0.85	13.27	13.52	0.47	N	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13741	13741	A	C	MI.22254	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1405	469	T	P	Act/Cct	-4.64	0	0	possibly_damaging	0.81	neutral	0.23	neutral	0.84	deleterious	-3.22	deleterious	-2.54	medium_impact	3.17	0.64	neutral	0.38	neutral	3.53	23.10	deleterious	0.16	0.45	0.56	disease	0.84	disease	0.74	disease	0.8	disease	6	0.87	neutral	0.21	neutral	0	NA	0.76	deleterious	-1.34	low_impact	-0.06	medium_impact	1.69	medium_impact	0.66	0.8	19.4	15.87	0.32	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13741	13741	A	G	MI.22255	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1405	469	T	A	Act/Gct	-4.64	0	0	benign	0.36	neutral	0.53	neutral	0.93	neutral	-0.83	neutral	-0.96	medium_impact	2.36	0.77	neutral	0.75	neutral	2.02	16.33	deleterious	0.61	0.65	0.42	neutral	0.44	neutral	0.6	disease	0.5	neutral	0	0.39	neutral	0.59	deleterious	-3	neutral	0.49	deleterious	-0.51	medium_impact	0.26	medium_impact	0.95	medium_impact	0.54	0.8	19.4	15.87	0.29	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13741	13741	A	T	MI.22256	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1405	469	T	S	Act/Tct	-4.64	0	0	benign	0.04	neutral	0.47	neutral	1.17	neutral	1.07	neutral	1.14	neutral_impact	0.59	0.82	neutral	0.96	neutral	1.11	11.25	neutral	0.44	0.55	0.29	neutral	0.21	neutral	0.33	neutral	0.36	neutral	3	0.49	neutral	0.72	deleterious	-6	neutral	0.55	deleterious	0.57	medium_impact	0.2	medium_impact	-0.66	medium_impact	0.63	0.8	19.4	15.87	0.33	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13742	13742	C	T	MI.22257	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1406	469	T	I	aCt/aTt	-0.06	0	0	benign	0.03	neutral	0.52	neutral	0.92	neutral	-0.94	deleterious	-2.94	low_impact	1.77	0.72	neutral	0.72	neutral	1.03	10.82	neutral	0.46	0.55	0.8	disease	0.66	disease	0.4	neutral	0.59	disease	2	0.45	neutral	0.75	deleterious	-6	neutral	0.24	neutral	0.69	medium_impact	0.25	medium_impact	0.41	medium_impact	0.67	0.85	19.4	15.87	0.28	N	0.89	polymorphism	1	0.06	rs386829191	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13742	13742	C	A	MI.22258	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1406	469	T	N	aCt/aAt	-0.06	0	0	possibly_damaging	0.69	neutral	0.32	neutral	0.89	neutral	-1.4	neutral	-1	medium_impact	2.19	0.81	neutral	0.74	neutral	3.61	23.20	deleterious	0.51	0.6	0.5	neutral	0.72	disease	0.59	disease	0.66	disease	3	0.75	neutral	0.32	neutral	0	NA	0.70	deleterious	-1.08	low_impact	0.05	medium_impact	0.8	medium_impact	0.70	0.85	19.4	15.87	0.28	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13742	13742	C	G	MI.22259	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1406	469	T	S	aCt/aGt	-0.06	0	0	benign	0.04	neutral	0.47	neutral	1.17	neutral	1.07	neutral	1.14	neutral_impact	0.59	0.82	neutral	0.96	neutral	1.27	12.14	neutral	0.44	0.55	0.29	neutral	0.21	neutral	0.33	neutral	0.36	neutral	3	0.49	neutral	0.72	deleterious	-6	neutral	0.55	deleterious	0.57	medium_impact	0.2	medium_impact	-0.66	medium_impact	0.63	0.8	19.4	15.87	0.34	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6069	6069	G	C	MI.2226	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	166	56	V	L	Gtt/Ctt	-3.34	0	0	benign	0.01	deleterious	0.04	neutral	2.9	neutral	-0.72	neutral	-1.41	medium_impact	3.48	0.56	damaging	0.15	damaging	3.39	23.00	deleterious	0.35	0.55	0.42	neutral	0.85	disease	0.3	neutral	0.67	disease	3	0.96	neutral	0.52	deleterious	1	deleterious	0.27	neutral	1.12	medium_impact	-0.58	medium_impact	2.11	high_impact	0.75	0.9	2.92	7.71	0.39	N	0.54	polymorphism	0.97	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13744	13744	A	T	MI.22260	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1408	470	N	Y	Aac/Tac	-3.5	0	0	benign	0.11	neutral	1	neutral	0.95	neutral	-1.01	deleterious	-3.85	low_impact	0.94	0.86	neutral	0.95	neutral	1.85	15.26	deleterious	0.38	0.5	0.54	disease	0.46	neutral	0.35	neutral	0.54	disease	1	0.11	neutral	0.95	deleterious	-6	neutral	0.69	deleterious	0.12	medium_impact	1.89	high_impact	-0.34	medium_impact	0.42	0.8	27.69	16.3	0.25	N	0.25	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13744	13744	A	C	MI.22261	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1408	470	N	H	Aac/Cac	-3.5	0	0	probably_damaging	0.91	neutral	0.54	neutral	0.93	neutral	-2.02	neutral	-2.22	neutral_impact	0.45	0.82	neutral	0.97	neutral	1.57	13.67	neutral	0.5	0.6	0.71	disease	0.34	neutral	0.44	neutral	0.64	disease	3	0.9	neutral	0.32	neutral	-2	neutral	0.71	deleterious	-1.7	low_impact	0.27	medium_impact	-0.79	medium_impact	0.47	0.8	27.69	16.3	0.28	N	0.10	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13744	13744	A	G	MI.22262	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1408	470	N	D	Aac/Gac	-3.5	0	0	possibly_damaging	0.64	neutral	0.24	neutral	0.94	neutral	-1.3	deleterious	-3.18	medium_impact	2.21	0.78	neutral	0.47	neutral	1.31	12.30	neutral	0.63	0.65	0.83	disease	0.37	neutral	0.53	disease	0.66	disease	3	0.79	neutral	0.3	neutral	0	NA	0.56	deleterious	-0.98	medium_impact	-0.04	medium_impact	0.82	medium_impact	0.51	0.8	27.69	16.3	0.33	N	0.67	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13745	13745	A	C	MI.22263	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1409	470	N	T	aAc/aCc	-3.27	0	0	benign	0.13	neutral	0.44	neutral	0.97	neutral	-0.45	deleterious	-3.45	neutral_impact	0.28	0.84	neutral	0.82	neutral	0.50	7.45	deleterious	0.44	0.55	0.44	neutral	0.27	neutral	0.31	neutral	0.46	neutral	1	0.48	neutral	0.66	deleterious	-6	neutral	0.44	deleterious	0.04	medium_impact	0.18	medium_impact	-0.95	medium_impact	0.52	0.8	27.69	16.3	0.33	N	0.35	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13745	13745	A	T	MI.22264	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1409	470	N	I	aAc/aTc	-3.27	0	0	possibly_damaging	0.88	neutral	0.42	neutral	0.95	neutral	-0.93	deleterious	-5.14	low_impact	1.12	0.87	neutral	0.78	neutral	2.64	20.40	deleterious	0.33	0.5	0.35	neutral	0.58	disease	0.46	neutral	0.51	disease	0	0.87	neutral	0.27	neutral	-3	neutral	0.64	deleterious	-1.57	low_impact	0.16	medium_impact	-0.18	medium_impact	0.36	0.8	27.69	16.3	0.33	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13745	13745	A	G	MI.22265	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1409	470	N	S	aAc/aGc	-3.27	0	0	benign	0.09	neutral	0.46	neutral	1.06	neutral	0.72	deleterious	-2.59	neutral_impact	-0.56	0.83	neutral	0.91	neutral	-1.41	0.00	neutral	0.64	0.7	0.41	neutral	0.07	neutral	0.27	neutral	0.19	neutral	6	0.48	neutral	0.69	deleterious	-6	neutral	0.15	neutral	0.21	medium_impact	0.19	medium_impact	-1.71	low_impact	0.29	0.8	27.69	16.3	0.39	N	0.29	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13746	13746	C	G	MI.22266	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1410	470	N	K	aaC/aaG	-0.29	0	0	possibly_damaging	0.64	neutral	0.35	neutral	0.98	neutral	-0.42	deleterious	-3.51	low_impact	1.87	0.82	neutral	0.59	neutral	1.27	12.13	neutral	0.63	0.65	0.72	disease	0.47	neutral	0.58	disease	0.63	disease	3	0.7	neutral	0.36	neutral	-3	neutral	0.62	deleterious	-0.98	medium_impact	0.08	medium_impact	0.51	medium_impact	0.52	0.8	27.69	16.3	0.3	N	0.70	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13746	13746	C	A	MI.22267	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1410	470	N	K	aaC/aaA	-0.29	0	0	possibly_damaging	0.64	neutral	0.35	neutral	0.98	neutral	-0.42	deleterious	-3.51	low_impact	1.87	0.82	neutral	0.59	neutral	1.76	14.74	neutral	0.63	0.65	0.72	disease	0.47	neutral	0.58	disease	0.63	disease	3	0.7	neutral	0.36	neutral	-3	neutral	0.62	deleterious	-0.98	medium_impact	0.08	medium_impact	0.51	medium_impact	0.52	0.8	27.69	16.3	0.3	N	0.70	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13747	13747	A	C	MI.22268	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1411	471	N	H	Aac/Cac	-5.1	0	0	possibly_damaging	0.83	neutral	0.54	neutral	0.89	neutral	-2.52	deleterious	-3.27	low_impact	1.6	0.82	neutral	0.61	neutral	2.98	22.20	deleterious	0.4	0.5	0.72	disease	0.71	disease	0.58	disease	0.64	disease	3	0.81	neutral	0.36	neutral	-3	neutral	0.74	deleterious	-1.4	low_impact	0.27	medium_impact	0.26	medium_impact	0.56	0.8	10.78	14.57	0.2	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13747	13747	A	T	MI.22269	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1411	471	N	Y	Aac/Tac	-5.1	0	0	benign	0.04	neutral	1	neutral	0.94	neutral	-0.92	deleterious	-4.99	low_impact	1.17	0.83	neutral	0.73	neutral	3.51	23.10	deleterious	0.35	0.5	0.53	disease	0.71	disease	0.5	neutral	0.54	disease	1	0.04	neutral	0.98	deleterious	-6	neutral	0.72	deleterious	0.57	medium_impact	1.89	high_impact	-0.13	medium_impact	0.52	0.8	10.78	14.57	0.21	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6069	6069	G	A	MI.2227	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	166	56	V	I	Gtt/Att	-3.34	0	0	benign	0.17	deleterious	0.02	neutral	2.87	neutral	-0.04	neutral	-0.56	medium_impact	2.92	0.58	damaging	0.15	damaging	3.56	23.10	deleterious	0.41	0.55	0.51	disease	0.77	disease	0.42	neutral	0.58	disease	2	0.98	neutral	0.43	neutral	1	deleterious	0.28	neutral	-0.11	medium_impact	-0.75	medium_impact	1.6	medium_impact	0.72	0.9	2.92	7.71	0.36	N	0.13	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13747	13747	A	G	MI.22270	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1411	471	N	D	Aac/Gac	-5.1	0	0	possibly_damaging	0.48	neutral	0.23	neutral	0.88	deleterious	-3.18	deleterious	-3.16	medium_impact	2.92	0.71	neutral	0.49	neutral	2.23	17.70	deleterious	0.56	0.6	0.73	disease	0.66	disease	0.74	disease	0.75	disease	5	0.74	neutral	0.38	neutral	0	NA	0.57	deleterious	-0.71	medium_impact	-0.06	medium_impact	1.46	medium_impact	0.80	0.85	10.78	14.57	0.33	N	0.72	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13748	13748	A	T	MI.22271	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1412	471	N	I	aAc/aTc	1.77	0	0.01	possibly_damaging	0.75	neutral	0.41	neutral	0.99	neutral	-0.13	deleterious	-5.52	low_impact	1.72	0.82	neutral	0.73	neutral	3.99	23.60	deleterious	0.3	0.45	0.42	neutral	0.82	disease	0.65	disease	0.57	disease	1	0.76	neutral	0.33	neutral	-3	neutral	0.69	deleterious	-1.2	low_impact	0.15	medium_impact	0.37	medium_impact	0.42	0.8	10.78	14.57	0.26	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13748	13748	A	G	MI.22272	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1412	471	N	S	aAc/aGc	1.77	0	0.01	benign	0.04	neutral	0.46	neutral	0.97	neutral	-0.44	neutral	-2.13	neutral_impact	0.68	0.89	neutral	0.98	neutral	0.13	3.91	deleterious	0.52	0.6	0.51	disease	0.53	disease	0.47	neutral	0.49	neutral	0	0.5	neutral	0.71	deleterious	-6	neutral	0.21	neutral	0.57	medium_impact	0.19	medium_impact	-0.58	medium_impact	0.51	0.8	10.78	14.57	0.3	N	0.09	polymorphism	1	0.02	rs879029751	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13748	13748	A	C	MI.22273	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1412	471	N	T	aAc/aCc	1.77	0	0.01	benign	0.36	neutral	0.43	neutral	0.95	neutral	-0.65	deleterious	-3.1	low_impact	1.2	0.86	neutral	0.81	neutral	1.89	15.52	deleterious	0.39	0.5	0.55	disease	0.59	disease	0.45	neutral	0.5	neutral	0	0.5	neutral	0.54	deleterious	-6	neutral	0.48	deleterious	-0.51	medium_impact	0.17	medium_impact	-0.11	medium_impact	0.55	0.8	10.78	14.57	0.33	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13749	13749	C	G	MI.22274	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1413	471	N	K	aaC/aaG	-0.52	0	0	possibly_damaging	0.48	neutral	0.33	neutral	0.91	neutral	-1.74	deleterious	-3.66	medium_impact	2.92	0.73	neutral	0.56	neutral	2.48	19.36	deleterious	0.6	0.65	0.72	disease	0.77	disease	0.76	disease	0.77	disease	5	0.64	neutral	0.43	neutral	0	NA	0.65	deleterious	-0.71	medium_impact	0.06	medium_impact	1.46	medium_impact	0.70	0.85	10.78	14.57	0.34	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13749	13749	C	A	MI.22275	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1413	471	N	K	aaC/aaA	-0.52	0	0	possibly_damaging	0.48	neutral	0.33	neutral	0.91	neutral	-1.74	deleterious	-3.66	medium_impact	2.92	0.73	neutral	0.56	neutral	3.01	22.30	deleterious	0.6	0.65	0.72	disease	0.77	disease	0.76	disease	0.77	disease	5	0.64	neutral	0.43	neutral	0	NA	0.65	deleterious	-0.71	medium_impact	0.06	medium_impact	1.46	medium_impact	0.70	0.85	10.78	14.57	0.35	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13750	13750	A	T	MI.22276	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1414	472	I	F	Att/Ttt	-1.89	0	0	possibly_damaging	0.88	neutral	0.78	neutral	0.7	neutral	-2.25	deleterious	-2.97	medium_impact	2.08	0.76	neutral	0.83	neutral	2.12	16.99	deleterious	0.47	0.55	0.54	disease	0.59	disease	0.4	neutral	0.5	neutral	0	0.86	neutral	0.45	neutral	0	NA	0.71	deleterious	-1.57	low_impact	0.54	medium_impact	0.7	medium_impact	0.83	0.85	6.63	10.34	0.22	N	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13750	13750	A	C	MI.22277	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1414	472	I	L	Att/Ctt	-1.89	0	0	benign	0.05	neutral	0.97	neutral	0.91	neutral	-0.4	neutral	-0.96	low_impact	1.24	0.82	neutral	0.95	neutral	2.28	18.06	deleterious	0.42	0.55	0.34	neutral	0.32	neutral	0.32	neutral	0.47	neutral	1	0.01	neutral	0.96	deleterious	-6	neutral	0.61	deleterious	0.47	medium_impact	1.07	medium_impact	-0.07	medium_impact	0.79	0.85	6.63	10.34	0.27	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13750	13750	A	G	MI.22278	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1414	472	I	V	Att/Gtt	-1.89	0	0	benign	0.09	neutral	0.56	neutral	0.74	neutral	-1.64	neutral	-0.7	low_impact	1.84	0.89	neutral	0.79	neutral	2.95	22.00	deleterious	0.62	0.65	0.44	neutral	0.25	neutral	0.41	neutral	0.45	neutral	1	0.36	neutral	0.74	deleterious	-6	neutral	0.62	deleterious	0.21	medium_impact	0.29	medium_impact	0.48	medium_impact	0.68	0.85	6.63	10.34	0.32	N	0.74	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13751	13751	T	A	MI.22279	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1415	472	I	N	aTt/aAt	1.31	0.01	0	probably_damaging	0.95	neutral	0.48	neutral	0.64	deleterious	-3.79	deleterious	-5.37	medium_impact	2.48	0.8	neutral	0.41	neutral	4.48	24.20	deleterious	0.31	0.45	0.87	disease	0.79	disease	0.59	disease	0.77	disease	5	0.95	neutral	0.27	neutral	1	deleterious	0.82	deleterious	-1.96	low_impact	0.21	medium_impact	1.06	medium_impact	0.62	0.8	6.63	10.34	0.26	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6069	6069	G	T	MI.2228	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	166	56	V	F	Gtt/Ttt	-3.34	0	0	possibly_damaging	0.82	deleterious	0	neutral	2.82	neutral	-2.19	neutral	-2.46	high_impact	4.28	0.52	damaging	0.11	damaging	3.73	23.30	deleterious	0.15	0.55	0.64	disease	0.95	disease	0.58	disease	0.8	disease	6	1	deleterious	0.09	neutral	5	deleterious	0.77	deleterious	-1.38	low_impact	-1.48	low_impact	2.85	high_impact	0.60	0.9	2.92	7.71	0.36	N	0.85	polymorphism	0.73	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13751	13751	T	C	MI.22280	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1415	472	I	T	aTt/aCt	1.31	0.01	0	possibly_damaging	0.73	neutral	0.52	neutral	0.7	neutral	-2.17	deleterious	-3.53	low_impact	1.5	0.85	neutral	0.97	neutral	2.33	18.37	deleterious	0.44	0.55	0.64	disease	0.45	neutral	0.41	neutral	0.61	disease	2	0.7	neutral	0.4	neutral	-3	neutral	0.74	deleterious	-1.16	low_impact	0.25	medium_impact	0.17	medium_impact	0.70	0.85	6.63	10.34	0.35	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13751	13751	T	G	MI.22281	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1415	472	I	S	aTt/aGt	1.31	0.01	0	possibly_damaging	0.77	neutral	0.57	neutral	0.65	deleterious	-3.22	deleterious	-4.47	medium_impact	2.25	0.78	neutral	0.72	neutral	4.33	24.00	deleterious	0.26	0.45	0.63	disease	0.74	disease	0.6	disease	0.58	disease	2	0.73	neutral	0.4	neutral	0	NA	0.77	deleterious	-1.24	low_impact	0.3	medium_impact	0.85	medium_impact	0.64	0.8	6.63	10.34	0.24	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13752	13752	T	A	MI.22282	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1416	472	I	M	atT/atA	1.77	0.02	0	probably_damaging	0.91	neutral	0.33	neutral	0.71	neutral	-2.08	neutral	-1.6	low_impact	1.56	0.86	neutral	0.98	neutral	2.62	20.30	deleterious	0.54	0.6	0.58	disease	0.3	neutral	0.35	neutral	0.6	disease	2	0.92	neutral	0.21	neutral	-2	neutral	0.68	deleterious	-1.7	low_impact	0.06	medium_impact	0.22	medium_impact	0.87	0.9	6.63	10.34	0.41	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13752	13752	T	G	MI.22283	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1416	472	I	M	atT/atG	1.77	0.02	0	probably_damaging	0.91	neutral	0.33	neutral	0.71	neutral	-2.08	neutral	-1.6	low_impact	1.56	0.86	neutral	0.98	neutral	2.41	18.89	deleterious	0.54	0.6	0.58	disease	0.3	neutral	0.35	neutral	0.6	disease	2	0.92	neutral	0.21	neutral	-2	neutral	0.68	deleterious	-1.7	low_impact	0.06	medium_impact	0.22	medium_impact	0.87	0.9	6.63	10.34	0.41	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13753	13753	T	A	MI.22284	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1417	473	S	T	Tcc/Acc	-8.31	0	0	benign	0.02	neutral	0.48	neutral	1.01	neutral	0.25	neutral	0.51	neutral_impact	-0.96	0.85	neutral	0.99	neutral	0.12	3.81	deleterious	0.36	0.5	0.6	disease	0.08	neutral	0.23	neutral	0.31	neutral	4	0.5	neutral	0.73	deleterious	-6	neutral	0.25	neutral	0.86	medium_impact	0.21	medium_impact	-2.08	low_impact	0.68	0.85	15.09	12.43	0.41	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13753	13753	T	G	MI.22285	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1417	473	S	A	Tcc/Gcc	-8.31	0	0	benign	0.12	neutral	0.54	neutral	1.01	neutral	0.22	neutral	-0.33	low_impact	0.84	0.85	neutral	0.85	neutral	0.14	4.03	deleterious	0.43	0.55	0.52	disease	0.12	neutral	0.37	neutral	0.23	neutral	5	0.37	neutral	0.71	deleterious	-6	neutral	0.15	neutral	0.08	medium_impact	0.27	medium_impact	-0.44	medium_impact	0.58	0.8	15.09	12.43	0.32	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13753	13753	T	C	MI.22286	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1417	473	S	P	Tcc/Ccc	-8.31	0	0	benign	0.01	neutral	0.28	neutral	1.05	neutral	0.78	neutral	2.89	neutral_impact	-1.27	0.91	neutral	1	neutral	-0.15	1.38	neutral	0.25	0.45	0.39	neutral	0.36	neutral	0.21	neutral	0.46	neutral	1	0.72	neutral	0.64	deleterious	-6	neutral	0.16	neutral	1.15	medium_impact	0.01	medium_impact	-2.36	low_impact	0.48	0.8	15.09	12.43	0.31	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13754	13754	C	T	MI.22287	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1418	473	S	F	tCc/tTc	-5.33	0	0	benign	0.01	neutral	0.74	neutral	1.24	neutral	2.27	neutral	-2.13	neutral_impact	0.03	0.76	neutral	0.77	neutral	0.56	7.87	deleterious	0.26	0.45	0.74	disease	0.44	neutral	0.32	neutral	0.63	disease	3	0.23	neutral	0.87	deleterious	-6	neutral	0.36	neutral	1.15	medium_impact	0.48	medium_impact	-1.18	low_impact	0.40	0.8	15.09	12.43	0.25	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13754	13754	C	G	MI.22288	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1418	473	S	C	tCc/tGc	-5.33	0	0	possibly_damaging	0.89	neutral	0.17	neutral	0.95	neutral	-1.88	neutral	-1.28	low_impact	1.38	0.83	neutral	0.45	neutral	2.31	18.25	deleterious	0.28	0.45	0.93	disease	0.48	neutral	0.3	neutral	0.7	disease	4	0.94	neutral	0.14	neutral	-3	neutral	0.68	deleterious	-1.61	low_impact	-0.15	medium_impact	0.06	medium_impact	0.64	0.8	15.09	12.43	0.33	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13754	13754	C	A	MI.22289	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1418	473	S	Y	tCc/tAc	-5.33	0	0	benign	0.38	neutral	1	neutral	0.96	neutral	-1.05	neutral	-1.67	low_impact	1.04	0.86	neutral	0.84	neutral	1.31	12.31	neutral	0.25	0.45	0.78	disease	0.43	neutral	0.39	neutral	0.64	disease	3	0.38	neutral	0.81	deleterious	-6	neutral	0.62	deleterious	-0.54	medium_impact	1.89	high_impact	-0.25	medium_impact	0.60	0.8	15.09	12.43	0.21	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6070	6070	T	A	MI.2229	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	167	56	V	D	gTt/gAt	5.22	1	0	probably_damaging	0.96	deleterious	0.01	neutral	2.8	deleterious	-4.08	deleterious	-3.19	high_impact	4.62	0.55	damaging	0.12	damaging	4.33	24.00	deleterious	0.09	0.55	0.4	neutral	0.94	disease	0.7	disease	0.82	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.82	deleterious	-2.06	low_impact	-0.92	medium_impact	3.17	high_impact	0.51	0.9	2.92	7.71	0.51	P	0.92	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13756	13756	C	G	MI.22290	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1420	474	P	A	Ccc/Gcc	-8.54	0	0	probably_damaging	1	neutral	0.51	neutral	0.7	neutral	-2.27	deleterious	-6.69	high_impact	3.74	0.67	neutral	0.17	damaging	3.26	22.80	deleterious	0.38	0.5	0.66	disease	0.49	neutral	0.68	disease	0.6	disease	2	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.24	medium_impact	2.21	high_impact	0.74	0.85	5.31	7.81	0.27	N	0.73	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13756	13756	C	A	MI.22291	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1420	474	P	T	Ccc/Acc	-8.54	0	0	probably_damaging	1	neutral	0.47	neutral	0.68	neutral	-2.55	deleterious	-6.65	medium_impact	2.5	0.68	neutral	0.27	damaging	3.84	23.40	deleterious	0.36	0.5	0.68	disease	0.73	disease	0.62	disease	0.62	disease	2	1	deleterious	0.24	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.2	medium_impact	1.08	medium_impact	0.70	0.85	5.31	7.81	0.22	N	0.91	polymorphism	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13756	13756	C	T	MI.22292	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1420	474	P	S	Ccc/Tcc	-8.54	0	0	probably_damaging	1	neutral	0.46	neutral	0.73	neutral	-1.8	deleterious	-6.69	medium_impact	3.05	0.67	neutral	0.12	damaging	4.08	23.70	deleterious	0.46	0.55	0.47	neutral	0.73	disease	0.6	disease	0.62	disease	2	1	deleterious	0.23	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.19	medium_impact	1.58	medium_impact	0.28	0.8	5.31	7.81	0.16	N	0.78	polymorphism	0.98	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13757	13757	C	A	MI.22293	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1421	474	P	H	cCc/cAc	2	0.09	0	probably_damaging	1	neutral	0.52	neutral	0.63	deleterious	-4.1	deleterious	-7.27	high_impact	3.74	0.68	neutral	0.13	damaging	4.17	23.80	deleterious	0.32	0.5	0.9	disease	0.79	disease	0.68	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.25	medium_impact	2.21	high_impact	0.48	0.8	5.31	7.81	0.31	N	0.72	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13757	13757	C	T	MI.22294	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1421	474	P	L	cCc/cTc	2	0.09	0	probably_damaging	1	neutral	0.71	neutral	0.71	neutral	-2.03	deleterious	-8.2	medium_impact	3.05	0.65	neutral	0.24	damaging	4.56	24.40	deleterious	0.38	0.5	0.62	disease	0.73	disease	0.6	disease	0.53	disease	1	1	deleterious	0.36	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.45	medium_impact	1.58	medium_impact	0.77	0.85	5.31	7.81	0.28	N	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13757	13757	C	G	MI.22295	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1421	474	P	R	cCc/cGc	2	0.09	0	probably_damaging	1	neutral	0.35	neutral	0.66	deleterious	-3.08	deleterious	-7.53	high_impact	3.74	0.63	neutral	0.13	damaging	3.78	23.40	deleterious	0.35	0.5	0.8	disease	0.84	disease	0.77	disease	0.82	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.08	medium_impact	2.21	high_impact	0.57	0.8	5.31	7.81	0.43	N	0.64	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13759	13759	G	T	MI.22296	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1423	475	A	S	Gca/Tca	-11.52	0	0.09	benign	0.18	neutral	0.44	neutral	3.79	neutral	-0.61	neutral	0.34	neutral_impact	-0.84	0.84	neutral	0.82	neutral	0.52	7.55	deleterious	0.42	0.5	0.62	disease	0.14	neutral	0.23	neutral	0.31	neutral	4	0.47	neutral	0.63	deleterious	-6	neutral	0.17	neutral	-0.12	medium_impact	0.18	medium_impact	-1.97	low_impact	0.69	0.85	11.94	9.67	0.4	N	0.08	polymorphism	1	0.00	rs386420024	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13759	13759	G	C	MI.22297	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1423	475	A	P	Gca/Cca	-11.52	0	0.09	possibly_damaging	0.62	neutral	0.26	neutral	3.68	neutral	-2.41	neutral	-1.1	neutral_impact	-0.31	0.78	neutral	0.68	neutral	2.12	17.01	deleterious	0.23	0.45	0.85	disease	0.58	disease	0.28	neutral	0.64	disease	3	0.76	neutral	0.32	neutral	-3	neutral	0.34	neutral	-0.95	medium_impact	-0.02	medium_impact	-1.49	low_impact	0.68	0.85	11.94	9.67	0.33	N	0.22	polymorphism	1	0.02	rs386420024	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13759	13759	G	A	MI.22298	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1423	475	A	T	Gca/Aca	-11.52	0	0.09	benign	0.01	neutral	0.47	neutral	3.76	neutral	-0.91	neutral	1.66	neutral_impact	-2.07	0.94	neutral	0.96	neutral	-0.29	0.69	neutral	0.44	0.55	0.39	neutral	0.06	neutral	0.21	neutral	0.25	neutral	5	0.52	neutral	0.73	deleterious	-6	neutral	0.08	neutral	1.15	medium_impact	0.2	medium_impact	-3.09	low_impact	0.72	0.85	11.94	9.67	0.44	N	0.07	polymorphism	1	0.00	rs386420024	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13760	13760	C	A	MI.22299	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1424	475	A	E	gCa/gAa	-1.67	0	0	benign	0.34	neutral	0.27	neutral	3.73	neutral	-1.08	neutral	-1	neutral_impact	0.17	0.85	neutral	0.71	neutral	1.68	14.30	neutral	0.26	0.45	0.71	disease	0.47	neutral	0.51	disease	0.63	disease	3	0.68	neutral	0.47	neutral	-6	neutral	0.25	neutral	-0.47	medium_impact	-0.01	medium_impact	-1.05	low_impact	0.70	0.85	11.94	9.67	0.36	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8631	8631	A	C	MI.223	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	105	35	K	N	aaA/aaC	-0.8	0	0	benign	0.01	neutral	0.43	neutral	4.35	neutral	-1.03	neutral	0.49	neutral_impact	-0.7	0.88	neutral	0.95	neutral	-1.08	0.01	neutral	0.65	0.7	0.34	neutral	0.14	neutral	0.25	neutral	0.22	neutral	6	0.56	neutral	0.71	deleterious	-6	neutral	0.14	neutral	1.14	medium_impact	0.22	medium_impact	-1.7	low_impact	0.60	0.9	20.35	18.29	0.44	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6070	6070	T	G	MI.2230	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	167	56	V	G	gTt/gGt	5.22	1	0	probably_damaging	0.95	deleterious	0.04	neutral	2.81	deleterious	-3.55	deleterious	-3.34	medium_impact	3.38	0.55	damaging	0.15	damaging	3.69	23.30	deleterious	0.13	0.55	0.3	neutral	0.9	disease	0.6	disease	0.75	disease	5	0.99	deleterious	0.05	neutral	5	deleterious	0.76	deleterious	-1.96	low_impact	-0.58	medium_impact	2.02	high_impact	0.51	0.9	2.92	7.71	0.42	N	0.74	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13760	13760	C	T	MI.22300	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1424	475	A	V	gCa/gTa	-1.67	0	0	benign	0.12	neutral	0.5	neutral	3.77	neutral	-0.59	neutral	0.49	neutral_impact	0.42	0.86	neutral	0.77	neutral	1.50	13.30	neutral	0.36	0.5	0.44	neutral	0.22	neutral	0.38	neutral	0.39	neutral	2	0.42	neutral	0.69	deleterious	-6	neutral	0.13	neutral	0.08	medium_impact	0.23	medium_impact	-0.82	medium_impact	0.69	0.85	11.94	9.67	0.35	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13760	13760	C	G	MI.22301	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1424	475	A	G	gCa/gGa	-1.67	0	0	benign	0.24	neutral	0.35	neutral	3.72	neutral	-1.11	neutral	-1.77	low_impact	0.98	0.84	neutral	0.64	neutral	1.11	11.29	neutral	0.32	0.5	0.8	disease	0.2	neutral	0.38	neutral	0.49	neutral	0	0.58	neutral	0.56	deleterious	-6	neutral	0.19	neutral	-0.27	medium_impact	0.08	medium_impact	-0.31	medium_impact	0.65	0.8	11.94	9.67	0.37	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13762	13762	T	A	MI.22302	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1426	476	S	T	Tcc/Acc	-5.79	0	0.02	benign	0.03	neutral	0.47	neutral	1.04	neutral	0.54	neutral	0.29	neutral_impact	-0.04	0.89	neutral	0.99	neutral	1.28	12.17	neutral	0.39	0.5	0.36	neutral	0.12	neutral	0.3	neutral	0.31	neutral	4	0.5	neutral	0.72	deleterious	-6	neutral	0.48	deleterious	0.69	medium_impact	0.2	medium_impact	-1.24	low_impact	0.53	0.8	17.08	12.86	0.47	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13762	13762	T	G	MI.22303	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1426	476	S	A	Tcc/Gcc	-5.79	0	0.02	benign	0.27	neutral	0.58	neutral	1.01	neutral	0.19	neutral	-1.91	medium_impact	1.96	0.82	neutral	0.8	neutral	1.22	11.86	neutral	0.55	0.6	0.49	neutral	0.18	neutral	0.53	disease	0.3	neutral	4	0.31	neutral	0.66	deleterious	-3	neutral	0.38	neutral	-0.34	medium_impact	0.31	medium_impact	0.59	medium_impact	0.54	0.8	17.08	12.86	0.32	N	0.18	polymorphism	1	0.02	rs879154715	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	13762	13762	T	C	MI.22304	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1426	476	S	P	Tcc/Ccc	-5.79	0	0.02	possibly_damaging	0.73	neutral	0.24	neutral	0.95	neutral	-0.98	deleterious	-2.69	low_impact	1.75	0.61	neutral	0.62	neutral	4.07	23.70	deleterious	0.34	0.5	0.73	disease	0.73	disease	0.52	disease	0.62	disease	2	0.83	neutral	0.26	neutral	-3	neutral	0.79	deleterious	-1.16	low_impact	-0.04	medium_impact	0.4	medium_impact	0.46	0.8	17.08	12.86	0.29	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	COSM6716782	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13763	13763	C	T	MI.22305	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1427	476	S	F	tCc/tTc	2	0	0	benign	0.03	neutral	0.72	neutral	0.93	neutral	-1.83	deleterious	-3.6	medium_impact	1.96	0.73	neutral	0.71	neutral	1.31	12.32	neutral	0.28	0.45	0.88	disease	0.61	disease	0.61	disease	0.76	disease	5	0.23	neutral	0.85	deleterious	-3	neutral	0.29	neutral	0.69	medium_impact	0.46	medium_impact	0.59	medium_impact	0.40	0.8	17.08	12.86	0.23	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13763	13763	C	G	MI.22306	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1427	476	S	C	tCc/tGc	2	0	0	probably_damaging	0.93	neutral	0.18	neutral	0.91	deleterious	-3.59	deleterious	-3	medium_impact	2.31	0.62	neutral	0.44	neutral	3.65	23.20	deleterious	0.38	0.5	0.93	disease	0.53	disease	0.56	disease	0.8	disease	6	0.96	neutral	0.13	neutral	1	deleterious	0.77	deleterious	-1.81	low_impact	-0.13	medium_impact	0.91	medium_impact	0.59	0.8	17.08	12.86	0.33	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13763	13763	C	A	MI.22307	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1427	476	S	Y	tCc/tAc	2	0	0	possibly_damaging	0.51	neutral	1	neutral	0.97	neutral	-0.6	deleterious	-3.33	low_impact	0.95	0.82	neutral	0.68	neutral	2.71	20.90	deleterious	0.3	0.45	0.61	disease	0.5	neutral	0.54	disease	0.63	disease	3	0.51	neutral	0.75	deleterious	-3	neutral	0.53	deleterious	-0.76	medium_impact	1.89	high_impact	-0.34	medium_impact	0.57	0.8	17.08	12.86	0.23	N	0.73	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13765	13765	C	A	MI.22308	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1429	477	P	T	Ccc/Acc	-3.27	0	0	benign	0	neutral	0.5	neutral	0.98	neutral	-0.15	neutral	2.48	neutral_impact	-0.38	0.81	neutral	0.97	neutral	-0.80	0.04	neutral	0.43	0.55	0.63	disease	0.07	neutral	0.21	neutral	0.33	neutral	4	0.5	neutral	0.75	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.23	medium_impact	-1.55	low_impact	0.68	0.85	28.19	19.7	0.35	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13765	13765	C	T	MI.22309	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1429	477	P	S	Ccc/Tcc	-3.27	0	0	benign	0.11	neutral	0.54	neutral	0.9	neutral	-0.82	neutral	0.96	low_impact	0.92	0.87	neutral	0.87	neutral	1.07	11.05	neutral	0.48	0.55	0.55	disease	0.29	neutral	0.34	neutral	0.57	disease	1	0.37	neutral	0.72	deleterious	-6	neutral	0.20	neutral	0.12	medium_impact	0.27	medium_impact	-0.36	medium_impact	0.27	0.8	28.19	19.7	0.29	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6070	6070	T	C	MI.2231	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	167	56	V	A	gTt/gCt	5.22	1	0	possibly_damaging	0.7	deleterious	0.02	neutral	2.89	neutral	-1.84	neutral	-1.64	medium_impact	2.81	0.57	damaging	0.16	damaging	3.39	23.00	deleterious	0.26	0.55	0.3	neutral	0.74	disease	0.36	neutral	0.53	disease	1	0.98	deleterious	0.16	neutral	4	deleterious	0.48	deleterious	-1.1	low_impact	-0.75	medium_impact	1.5	medium_impact	0.58	0.9	2.92	7.71	0.53	P	0.10	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13765	13765	C	G	MI.22310	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1429	477	P	A	Ccc/Gcc	-3.27	0	0	benign	0.05	neutral	0.63	neutral	0.86	neutral	-1.43	neutral	1.07	medium_impact	1.97	0.84	neutral	0.79	neutral	1.27	12.12	neutral	0.42	0.55	0.62	disease	0.16	neutral	0.59	disease	0.37	neutral	3	0.3	neutral	0.79	deleterious	-3	neutral	0.16	neutral	0.47	medium_impact	0.36	medium_impact	0.6	medium_impact	0.72	0.85	28.19	19.7	0.3	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13766	13766	C	T	MI.22311	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1430	477	P	L	cCc/cTc	-0.98	0	0	benign	0	neutral	0.72	neutral	0.85	neutral	-1.53	neutral	2.01	neutral_impact	0.72	0.87	neutral	0.84	neutral	1.43	12.95	neutral	0.45	0.55	0.78	disease	0.4	neutral	0.57	disease	0.68	disease	4	0.27	neutral	0.86	deleterious	-6	neutral	0.20	neutral	2.1	high_impact	0.46	medium_impact	-0.55	medium_impact	0.79	0.85	28.19	19.7	0.28	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13766	13766	C	G	MI.22312	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1430	477	P	R	cCc/cGc	-0.98	0	0	benign	0.11	neutral	0.44	neutral	0.81	neutral	-2.41	neutral	-0.13	medium_impact	2.31	0.76	neutral	0.47	neutral	1.99	16.13	deleterious	0.36	0.5	0.64	disease	0.58	disease	0.68	disease	0.72	disease	4	0.49	neutral	0.67	deleterious	-3	neutral	0.38	neutral	0.12	medium_impact	0.18	medium_impact	0.91	medium_impact	0.65	0.8	28.19	19.7	0.31	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13766	13766	C	A	MI.22313	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1430	477	P	H	cCc/cAc	-0.98	0	0	benign	0.01	neutral	0.56	neutral	0.8	neutral	-2.73	neutral	-0.43	medium_impact	2.31	0.83	neutral	0.66	neutral	3.88	23.50	deleterious	0.41	0.5	0.8	disease	0.39	neutral	0.66	disease	0.69	disease	4	0.42	neutral	0.78	deleterious	-3	neutral	0.64	deleterious	1.15	medium_impact	0.29	medium_impact	0.91	medium_impact	0.59	0.8	28.19	19.7	0.29	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13768	13768	T	C	MI.22314	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1432	478	F	L	Ttc/Ctc	-11.98	0	0.01	benign	0	neutral	0.67	neutral	1.07	neutral	1.7	neutral	0.58	neutral_impact	-1.15	0.85	neutral	0.84	neutral	2.27	17.98	deleterious	0.46	0.55	0.57	disease	0.25	neutral	0.42	neutral	0.54	disease	1	0.32	neutral	0.84	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	0.4	medium_impact	-2.25	low_impact	0.48	0.8	25.7	17.51	0.35	N	0.26	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13768	13768	T	A	MI.22315	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1432	478	F	I	Ttc/Atc	-11.98	0	0.01	benign	0.01	neutral	0.42	neutral	1.06	neutral	1.5	neutral	0.5	neutral_impact	-2.14	0.81	neutral	0.95	neutral	1.49	13.24	neutral	0.25	0.45	0.74	disease	0.21	neutral	0.31	neutral	0.5	neutral	0	0.57	neutral	0.71	deleterious	-6	neutral	0.19	neutral	1.15	medium_impact	0.16	medium_impact	-3.16	low_impact	0.49	0.8	25.7	17.51	0.36	N	0.26	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13768	13768	T	G	MI.22316	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1432	478	F	V	Ttc/Gtc	-11.98	0	0.01	benign	0	neutral	0.51	neutral	1.07	neutral	1.73	neutral	1.23	neutral_impact	-1.04	0.79	neutral	0.88	neutral	2.30	18.19	deleterious	0.37	0.5	0.68	disease	0.36	neutral	0.55	disease	0.64	disease	3	0.49	neutral	0.76	deleterious	-6	neutral	0.19	neutral	2.1	high_impact	0.24	medium_impact	-2.15	low_impact	0.43	0.8	25.7	17.51	0.35	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13769	13769	T	G	MI.22317	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1433	478	F	C	tTc/tGc	1.54	0	0	benign	0.02	neutral	0.17	neutral	1.01	neutral	0.3	neutral	0.34	neutral_impact	0	0.7	neutral	0.45	neutral	2.34	18.41	deleterious	0.26	0.45	0.9	disease	0.53	disease	0.57	disease	0.76	disease	5	0.82	neutral	0.58	deleterious	-6	neutral	0.26	neutral	0.86	medium_impact	-0.15	medium_impact	-1.2	low_impact	0.30	0.8	25.7	17.51	0.38	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13769	13769	T	A	MI.22318	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1433	478	F	Y	tTc/tAc	1.54	0	0	benign	0.01	neutral	1	neutral	1.1	neutral	2.07	neutral	0.88	neutral_impact	0	0.82	neutral	0.65	neutral	2.44	19.07	deleterious	0.38	0.5	0.58	disease	0.27	neutral	0.53	disease	0.57	disease	1	0.01	neutral	1	deleterious	-6	neutral	0.19	neutral	1.15	medium_impact	1.89	high_impact	-1.2	low_impact	0.50	0.8	25.7	17.51	0.3	N	0.15	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13769	13769	T	C	MI.22319	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1433	478	F	S	tTc/tCc	1.54	0	0	benign	0	neutral	0.41	neutral	1.1	neutral	2.1	neutral	2.12	neutral_impact	-1.32	0.82	neutral	0.9	neutral	2.43	19.00	deleterious	0.39	0.5	0.49	neutral	0.36	neutral	0.37	neutral	0.42	neutral	2	0.59	neutral	0.71	deleterious	-6	neutral	0.18	neutral	2.1	high_impact	0.15	medium_impact	-2.41	low_impact	0.42	0.8	25.7	17.51	0.34	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6072	6072	A	G	MI.2232	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	169	57	I	V	Atc/Gtc	-9.82	0	0	benign	0.01	neutral	0.42	neutral	2.79	neutral	-0.21	neutral	-0.46	low_impact	1.34	0.72	neutral	0.94	neutral	-0.27	0.77	neutral	0.51	0.6	0.2	neutral	0.36	neutral	0.35	neutral	0.43	neutral	2	0.57	neutral	0.71	deleterious	-6	neutral	0.14	neutral	1.12	medium_impact	0.12	medium_impact	0.14	medium_impact	0.66	0.9	5.26	53.05	0.47	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13770	13770	C	G	MI.22320	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1434	478	F	L	ttC/ttG	0.86	0	0	benign	0	neutral	0.67	neutral	1.07	neutral	1.7	neutral	0.58	neutral_impact	-1.15	0.85	neutral	0.84	neutral	2.57	19.91	deleterious	0.46	0.55	0.57	disease	0.25	neutral	0.42	neutral	0.54	disease	1	0.32	neutral	0.84	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	0.4	medium_impact	-2.25	low_impact	0.48	0.8	25.7	17.51	0.36	N	0.26	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13770	13770	C	A	MI.22321	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1434	478	F	L	ttC/ttA	0.86	0	0	benign	0	neutral	0.67	neutral	1.07	neutral	1.7	neutral	0.58	neutral_impact	-1.15	0.85	neutral	0.84	neutral	2.85	21.60	deleterious	0.46	0.55	0.57	disease	0.25	neutral	0.42	neutral	0.54	disease	1	0.32	neutral	0.84	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	0.4	medium_impact	-2.25	low_impact	0.48	0.8	25.7	17.51	0.36	N	0.26	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13771	13771	C	A	MI.22322	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1435	479	Q	K	Caa/Aaa	-10.37	0	0	possibly_damaging	0.89	neutral	0.98	neutral	0.98	neutral	-0.83	deleterious	-2.61	medium_impact	2.19	0.82	neutral	0.54	neutral	1.48	13.19	neutral	0.54	0.6	0.57	disease	0.46	neutral	0.6	disease	0.64	disease	3	0.89	neutral	0.55	deleterious	0	NA	0.74	deleterious	-1.61	low_impact	1.17	medium_impact	0.8	medium_impact	0.54	0.8	28.69	18.45	0.2	N	0.56	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13771	13771	C	G	MI.22323	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1435	479	Q	E	Caa/Gaa	-10.37	0	0	possibly_damaging	0.84	neutral	0.97	neutral	0.99	neutral	-0.4	neutral	-1.94	low_impact	1.5	0.85	neutral	0.9	neutral	0.56	7.87	deleterious	0.57	0.65	0.4	neutral	0.38	neutral	0.58	disease	0.49	neutral	0	0.83	neutral	0.57	deleterious	-3	neutral	0.69	deleterious	-1.43	low_impact	1.07	medium_impact	0.17	medium_impact	0.59	0.8	28.69	18.45	0.29	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13772	13772	A	C	MI.22324	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1436	479	Q	P	cAa/cCa	-0.52	0	0	benign	0.12	neutral	0.44	neutral	1.03	neutral	0.54	deleterious	-3.63	neutral_impact	-0.61	0.85	neutral	0.92	neutral	1.98	16.06	deleterious	0.25	0.45	0.76	disease	0.45	neutral	0.35	neutral	0.65	disease	3	0.49	neutral	0.66	deleterious	-6	neutral	0.79	deleterious	0.08	medium_impact	0.18	medium_impact	-1.76	low_impact	0.45	0.8	28.69	18.45	0.26	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13772	13772	A	G	MI.22325	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1436	479	Q	R	cAa/cGa	-0.52	0	0	probably_damaging	0.95	neutral	0.68	neutral	0.97	neutral	-1.01	deleterious	-2.68	medium_impact	2.19	0.82	neutral	0.48	neutral	1.62	13.97	neutral	0.62	0.65	0.63	disease	0.47	neutral	0.63	disease	0.66	disease	3	0.94	neutral	0.37	neutral	1	deleterious	0.77	deleterious	-1.96	low_impact	0.41	medium_impact	0.8	medium_impact	0.43	0.8	28.69	18.45	0.21	N	0.49	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13772	13772	A	T	MI.22326	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1436	479	Q	L	cAa/cTa	-0.52	0	0	probably_damaging	0.94	neutral	0.9	neutral	1.14	neutral	1.85	deleterious	-4.23	low_impact	0.91	0.84	neutral	0.92	neutral	2.21	17.60	deleterious	0.34	0.5	0.26	neutral	0.44	neutral	0.36	neutral	0.46	neutral	1	0.93	neutral	0.48	deleterious	-2	neutral	0.66	deleterious	-1.88	low_impact	0.76	medium_impact	-0.37	medium_impact	0.15	0.8	28.69	18.45	0.26	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13773	13773	A	T	MI.22327	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1437	479	Q	H	caA/caT	-0.29	0	0	probably_damaging	0.99	neutral	0.55	neutral	0.96	neutral	-1.64	deleterious	-3.25	medium_impact	2.19	0.81	neutral	0.64	neutral	2.28	18.01	deleterious	0.65	0.7	0.74	disease	0.31	neutral	0.45	neutral	0.64	disease	3	0.99	deleterious	0.28	neutral	1	deleterious	0.74	deleterious	-2.64	low_impact	0.28	medium_impact	0.8	medium_impact	0.59	0.8	28.69	18.45	0.27	N	0.57	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13773	13773	A	C	MI.22328	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1437	479	Q	H	caA/caC	-0.29	0	0	probably_damaging	0.99	neutral	0.55	neutral	0.96	neutral	-1.64	deleterious	-3.25	medium_impact	2.19	0.81	neutral	0.64	neutral	2.05	16.55	deleterious	0.65	0.7	0.74	disease	0.31	neutral	0.45	neutral	0.64	disease	3	0.99	deleterious	0.28	neutral	1	deleterious	0.74	deleterious	-2.64	low_impact	0.28	medium_impact	0.8	medium_impact	0.59	0.8	28.69	18.45	0.27	N	0.57	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13774	13774	A	C	MI.22329	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1438	480	T	P	Aca/Cca	-2.58	0	0	benign	0	neutral	0.27	neutral	0.96	neutral	-0.76	neutral	-1.39	low_impact	1.44	0.79	neutral	0.63	neutral	3.43	23.00	deleterious	0.23	0.45	0.81	disease	0.73	disease	0.58	disease	0.7	disease	4	0.73	neutral	0.64	deleterious	-6	neutral	0.76	deleterious	2.1	high_impact	-0.01	medium_impact	0.11	medium_impact	0.64	0.8	23.38	16.6	0.26	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6072	6072	A	C	MI.2233	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	169	57	I	L	Atc/Ctc	-9.82	0	0	benign	0.07	neutral	0.14	neutral	2.83	neutral	0.87	neutral	-0.93	low_impact	1.25	0.66	neutral	0.88	neutral	0.64	8.45	deleterious	0.3	0.55	0.22	neutral	0.58	disease	0.31	neutral	0.44	neutral	1	0.85	neutral	0.54	deleterious	-6	neutral	0.20	neutral	0.3	medium_impact	-0.25	medium_impact	0.06	medium_impact	0.71	0.9	5.26	53.05	0.52	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13774	13774	A	G	MI.22330	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1438	480	T	A	Aca/Gca	-2.58	0	0	benign	0.05	neutral	0.54	neutral	0.98	neutral	-0.31	neutral	-0.32	medium_impact	2.24	0.8	neutral	0.81	neutral	1.75	14.69	neutral	0.63	0.65	0.45	neutral	0.24	neutral	0.6	disease	0.47	neutral	1	0.4	neutral	0.75	deleterious	-3	neutral	0.29	neutral	0.47	medium_impact	0.27	medium_impact	0.84	medium_impact	0.37	0.8	23.38	16.6	0.31	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13774	13774	A	T	MI.22331	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1438	480	T	S	Aca/Tca	-2.58	0	0	benign	0.01	neutral	0.45	neutral	0.98	neutral	-0.35	neutral	-0.45	medium_impact	2.24	0.77	neutral	0.71	neutral	1.65	14.12	neutral	0.51	0.6	0.61	disease	0.34	neutral	0.56	disease	0.63	disease	3	0.54	neutral	0.72	deleterious	-3	neutral	0.41	neutral	1.15	medium_impact	0.18	medium_impact	0.84	medium_impact	0.70	0.85	23.38	16.6	0.34	N	0.12	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13775	13775	C	A	MI.22332	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1439	480	T	K	aCa/aAa	0.86	0	0	benign	0.11	neutral	0.35	neutral	0.93	neutral	-1.79	neutral	-0.59	low_impact	1.9	0.72	neutral	0.61	neutral	3.00	22.20	deleterious	0.33	0.5	0.58	disease	0.6	disease	0.71	disease	0.74	disease	5	0.6	neutral	0.62	deleterious	-6	neutral	0.52	deleterious	0.12	medium_impact	0.08	medium_impact	0.53	medium_impact	0.59	0.8	23.38	16.6	0.35	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13775	13775	C	T	MI.22333	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1439	480	T	M	aCa/aTa	0.86	0	0	benign	0.02	neutral	0.25	neutral	1.12	neutral	1.17	neutral	4.05	neutral_impact	-0.88	0.83	neutral	0.99	neutral	-0.50	0.22	neutral	0.45	0.55	0.45	neutral	0.05	neutral	0.17	neutral	0.25	neutral	5	0.74	neutral	0.62	deleterious	-6	neutral	0.14	neutral	0.86	medium_impact	-0.03	medium_impact	-2.01	low_impact	0.77	0.85	23.38	16.6	0.5	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13777	13777	A	T	MI.22334	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1441	481	T	S	Aca/Tca	-0.06	0	0	possibly_damaging	0.81	neutral	0.54	neutral	0.74	neutral	-2.49	deleterious	-3.58	medium_impact	2.64	0.71	neutral	0.66	neutral	2.45	19.14	deleterious	0.57	0.65	0.63	disease	0.38	neutral	0.44	neutral	0.59	disease	2	0.79	neutral	0.37	neutral	0	NA	0.75	deleterious	-1.34	low_impact	0.27	medium_impact	1.21	medium_impact	0.77	0.85	11.11	6.9	0.31	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13777	13777	A	C	MI.22335	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1441	481	T	P	Aca/Cca	-0.06	0	0	probably_damaging	0.98	neutral	0.33	neutral	0.7	deleterious	-3.52	deleterious	-5.33	high_impact	3.88	0.67	neutral	0.48	neutral	3.64	23.20	deleterious	0.21	0.45	0.88	disease	0.79	disease	0.7	disease	0.78	disease	6	0.98	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-2.35	low_impact	0.06	medium_impact	2.34	high_impact	0.51	0.8	11.11	6.9	0.35	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13777	13777	A	G	MI.22336	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1441	481	T	A	Aca/Gca	-0.06	0	0	benign	0.17	neutral	0.57	neutral	0.75	neutral	-2.17	deleterious	-4.46	high_impact	3.88	0.81	neutral	0.54	neutral	3.63	23.20	deleterious	0.66	0.7	0.67	disease	0.43	neutral	0.7	disease	0.66	disease	3	0.32	neutral	0.7	deleterious	-2	neutral	0.76	deleterious	-0.09	medium_impact	0.3	medium_impact	2.34	high_impact	0.35	0.8	11.11	6.9	0.35	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13778	13778	C	A	MI.22337	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1442	481	T	K	aCa/aAa	6.13	1	0	probably_damaging	0.91	neutral	0.44	neutral	0.7	deleterious	-3.46	deleterious	-5.33	high_impact	3.88	0.75	neutral	0.4	neutral	4.65	24.50	deleterious	0.29	0.45	0.73	disease	0.78	disease	0.8	disease	0.8	disease	6	0.91	neutral	0.27	neutral	2	deleterious	0.83	deleterious	-1.7	low_impact	0.18	medium_impact	2.34	high_impact	0.62	0.8	11.11	6.9	0.65	P	1.00	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13778	13778	C	T	MI.22338	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1442	481	T	M	aCa/aTa	6.13	1	0	possibly_damaging	0.61	neutral	0.52	neutral	0.74	neutral	-2.38	deleterious	-4.74	high_impact	3.54	0.76	neutral	0.58	neutral	4.09	23.70	deleterious	0.43	0.55	0.41	neutral	0.61	disease	0.74	disease	0.61	disease	2	0.58	neutral	0.46	neutral	1	deleterious	0.72	deleterious	-0.93	medium_impact	0.25	medium_impact	2.03	high_impact	0.75	0.85	11.11	6.9	0.57	P	0.93	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13780	13780	A	T	MI.22339	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1444	482	I	F	Atc/Ttc	-14.73	0	0.05	benign	0.26	neutral	0.71	neutral	0.95	neutral	-0.75	neutral	-0.99	neutral_impact	0.49	0.71	neutral	0.63	neutral	2.36	18.58	deleterious	0.58	0.65	0.76	disease	0.61	disease	0.62	disease	0.7	disease	4	0.2	neutral	0.73	deleterious	-6	neutral	0.55	deleterious	-0.32	medium_impact	0.45	medium_impact	-0.76	medium_impact	0.63	0.8	8.13	10.88	0.24	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6072	6072	A	T	MI.2234	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	169	57	I	F	Atc/Ttc	-9.82	0	0	possibly_damaging	0.55	deleterious	0.02	neutral	2.65	neutral	-0.96	neutral	-2.28	medium_impact	3.03	0.57	damaging	0.1	damaging	3.27	22.80	deleterious	0.26	0.55	0.54	disease	0.83	disease	0.4	neutral	0.55	disease	1	0.98	neutral	0.24	neutral	4	deleterious	0.65	deleterious	-0.84	medium_impact	-0.75	medium_impact	1.7	medium_impact	0.76	0.9	5.26	53.05	0.26	N	0.84	polymorphism	0.87	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13780	13780	A	G	MI.22340	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1444	482	I	V	Atc/Gtc	-14.73	0	0.05	benign	0.01	neutral	0.51	neutral	1.06	neutral	0.54	neutral	-0.03	neutral_impact	0.69	0.8	neutral	0.64	neutral	1.28	12.18	neutral	0.62	0.65	0.56	disease	0.23	neutral	0.57	disease	0.54	disease	1	0.48	neutral	0.75	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.24	medium_impact	-0.57	medium_impact	0.46	0.8	8.13	10.88	0.27	N	0.18	polymorphism	1	0.01	rs41358152	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13780	13780	A	C	MI.22341	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1444	482	I	L	Atc/Ctc	-14.73	0	0.05	benign	0.02	neutral	0.67	neutral	1.25	neutral	1.62	neutral	0.81	neutral_impact	-0.35	0.73	neutral	0.77	neutral	2.04	16.44	deleterious	0.47	0.55	0.54	disease	0.31	neutral	0.47	neutral	0.5	neutral	0	0.3	neutral	0.83	deleterious	-6	neutral	0.20	neutral	0.86	medium_impact	0.4	medium_impact	-1.52	low_impact	0.55	0.8	8.13	10.88	0.36	N	0.25	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13781	13781	T	G	MI.22342	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1445	482	I	S	aTc/aGc	8.42	1	0	benign	0.18	neutral	0.42	neutral	0.92	neutral	-1.33	neutral	-1.91	low_impact	1.04	0.71	neutral	0.67	neutral	2.61	20.30	deleterious	0.4	0.5	0.7	disease	0.62	disease	0.62	disease	0.7	disease	4	0.5	neutral	0.62	deleterious	-6	neutral	0.40	neutral	-0.12	medium_impact	0.16	medium_impact	-0.25	medium_impact	0.59	0.8	8.13	10.88	0.53	P	0.28	polymorphism	0.8	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13781	13781	T	C	MI.22343	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1445	482	I	T	aTc/aCc	8.42	1	0	benign	0.02	neutral	0.41	neutral	0.94	neutral	-0.85	neutral	-1.88	low_impact	1.04	0.78	neutral	0.72	neutral	1.63	14.04	neutral	0.48	0.55	0.64	disease	0.35	neutral	0.58	disease	0.63	disease	3	0.57	neutral	0.7	deleterious	-6	neutral	0.22	neutral	0.86	medium_impact	0.15	medium_impact	-0.25	medium_impact	0.52	0.8	8.13	10.88	0.56	P	0.19	polymorphism	0.94	0.03	rs386829193	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13781	13781	T	A	MI.22344	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1445	482	I	N	aTc/aAc	8.42	1	0	possibly_damaging	0.47	neutral	0.32	neutral	0.88	deleterious	-3.01	deleterious	-2.81	low_impact	1.04	0.69	neutral	0.52	neutral	4.37	24.10	deleterious	0.45	0.55	0.79	disease	0.77	disease	0.63	disease	0.78	disease	6	0.64	neutral	0.43	neutral	-3	neutral	0.69	deleterious	-0.7	medium_impact	0.05	medium_impact	-0.25	medium_impact	0.57	0.8	8.13	10.88	0.49	N	0.51	polymorphism	0.84	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13782	13782	C	A	MI.22345	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1446	482	I	M	atC/atA	4.52	1	0	benign	0.02	neutral	0.23	neutral	1.19	neutral	1.34	neutral	3.38	neutral_impact	-2.8	0.82	neutral	0.94	neutral	-0.63	0.10	neutral	0.67	0.7	0.42	neutral	0.05	neutral	0.18	neutral	0.26	neutral	5	0.76	neutral	0.61	deleterious	-6	neutral	0.15	neutral	0.86	medium_impact	-0.06	medium_impact	-3.76	low_impact	0.71	0.85	8.13	10.88	0.57	P	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13782	13782	C	G	MI.22346	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1446	482	I	M	atC/atG	4.52	1	0	benign	0.02	neutral	0.23	neutral	1.19	neutral	1.34	neutral	3.38	neutral_impact	-2.8	0.82	neutral	0.94	neutral	-1.07	0.01	neutral	0.67	0.7	0.42	neutral	0.05	neutral	0.18	neutral	0.26	neutral	5	0.76	neutral	0.61	deleterious	-6	neutral	0.15	neutral	0.86	medium_impact	-0.06	medium_impact	-3.76	low_impact	0.71	0.85	8.13	10.88	0.57	P	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13783	13783	C	G	MI.22347	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1447	483	P	A	Ccc/Gcc	0.4	0.98	0	probably_damaging	1	neutral	0.51	neutral	0.39	deleterious	-3.35	deleterious	-7.18	medium_impact	3.34	0.6	neutral	0.1	damaging	3.22	22.70	deleterious	0.42	0.55	0.54	disease	0.5	neutral	0.67	disease	0.59	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.24	medium_impact	1.85	medium_impact	0.77	0.85	27.53	7.11	0.38	N	0.73	disease_causing	0.98	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13783	13783	C	A	MI.22348	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1447	483	P	T	Ccc/Acc	0.4	0.98	0	probably_damaging	1	neutral	0.43	neutral	0.41	deleterious	-3.14	deleterious	-7.18	medium_impact	2.91	0.52	damaging	0.06	damaging	3.78	23.40	deleterious	0.39	0.5	0.56	disease	0.69	disease	0.65	disease	0.54	disease	1	1	deleterious	0.22	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.17	medium_impact	1.46	medium_impact	0.70	0.85	27.53	7.11	0.33	N	0.91	disease_causing	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13783	13783	C	T	MI.22349	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1447	483	P	S	Ccc/Tcc	0.4	0.98	0	probably_damaging	1	neutral	0.42	neutral	0.52	neutral	-1.97	deleterious	-7.18	medium_impact	2.84	0.63	neutral	0.1	damaging	3.96	23.60	deleterious	0.56	0.6	0.45	neutral	0.73	disease	0.64	disease	0.53	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.16	medium_impact	1.39	medium_impact	0.23	0.8	27.53	7.11	0.34	N	0.78	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6073	6073	T	C	MI.2235	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	170	57	I	T	aTc/aCc	-0.11	0	0	benign	0.33	deleterious	0.02	neutral	2.66	neutral	-1.54	deleterious	-2.78	medium_impact	3.08	0.62	neutral	0.13	damaging	1.56	13.63	neutral	0.26	0.55	0.47	neutral	0.81	disease	0.56	disease	0.69	disease	4	0.98	neutral	0.35	neutral	1	deleterious	0.43	neutral	-0.47	medium_impact	-0.75	medium_impact	1.75	medium_impact	0.61	0.9	5.26	53.05	0.28	N	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13784	13784	C	A	MI.22350	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1448	483	P	H	cCc/cAc	4.29	1	0	probably_damaging	1	neutral	0.54	neutral	0.34	deleterious	-5.04	deleterious	-8.07	medium_impact	3.34	0.58	damaging	0.07	damaging	4.12	23.80	deleterious	0.35	0.5	0.51	disease	0.79	disease	0.76	disease	0.74	disease	5	1	deleterious	0.27	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.27	medium_impact	1.85	medium_impact	0.57	0.8	27.53	7.11	0.4	N	0.72	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13784	13784	C	G	MI.22351	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1448	483	P	R	cCc/cGc	4.29	1	0	probably_damaging	1	neutral	0.35	neutral	0.35	deleterious	-4.61	deleterious	-8.08	high_impact	3.88	0.57	damaging	0.1	damaging	3.75	23.30	deleterious	0.32	0.5	0.63	disease	0.86	disease	0.82	disease	0.84	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.08	medium_impact	2.34	high_impact	0.68	0.85	27.53	7.11	0.52	P	0.64	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13784	13784	C	T	MI.22352	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1448	483	P	L	cCc/cTc	4.29	1	0	probably_damaging	1	neutral	0.68	neutral	0.34	deleterious	-4.89	deleterious	-8.98	high_impact	3.88	0.59	damaging	0.07	damaging	4.53	24.30	deleterious	0.45	0.55	0.56	disease	0.83	disease	0.7	disease	0.75	disease	5	1	deleterious	0.34	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.41	medium_impact	2.34	high_impact	0.75	0.85	27.53	7.11	0.42	N	0.97	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13786	13786	C	T	MI.22353	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1450	484	L	F	Ctc/Ttc	-20	0	0	benign	0.03	neutral	0.7	neutral	0.87	neutral	-1.06	neutral	-0.82	neutral_impact	0.65	0.81	neutral	0.94	neutral	1.77	14.79	neutral	0.54	0.6	NA	NA	0.36	neutral	0.25	neutral	0.16	neutral	7	0.25	neutral	0.84	deleterious	-6	neutral	0.68	deleterious	0.69	medium_impact	0.44	medium_impact	-0.61	medium_impact	0.63	0.8	25.7	14.61	0.32	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13786	13786	C	G	MI.22354	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1450	484	L	V	Ctc/Gtc	-20	0	0	benign	0.27	neutral	0.5	neutral	0.9	neutral	-0.7	neutral	-0.77	low_impact	1.83	0.81	neutral	0.78	neutral	1.42	12.89	neutral	0.48	0.55	NA	NA	0.28	neutral	0.38	neutral	0.16	neutral	7	0.4	neutral	0.62	deleterious	-6	neutral	0.57	deleterious	-0.34	medium_impact	0.23	medium_impact	0.47	medium_impact	0.60	0.8	25.7	14.61	0.32	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13786	13786	C	A	MI.22355	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1450	484	L	I	Ctc/Atc	-20	0	0	benign	0.37	neutral	0.41	neutral	0.88	neutral	-0.99	neutral	-0.55	low_impact	1.28	0.82	neutral	0.93	neutral	2.28	18.04	deleterious	0.51	0.6	NA	NA	0.22	neutral	0.25	neutral	0.17	neutral	7	0.52	neutral	0.52	deleterious	-6	neutral	0.60	deleterious	-0.53	medium_impact	0.15	medium_impact	-0.03	medium_impact	0.70	0.85	25.7	14.61	0.43	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13787	13787	T	C	MI.22356	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1451	484	L	P	cTc/cCc	-6.94	0	0	benign	0.03	neutral	0.24	neutral	0.81	neutral	-1.88	neutral	-2.08	neutral_impact	0.1	0.86	neutral	0.98	neutral	0.45	7.01	deleterious	0.22	0.45	NA	NA	0.4	neutral	0.47	neutral	0.14	neutral	7	0.75	neutral	0.61	deleterious	-6	neutral	0.18	neutral	0.69	medium_impact	-0.04	medium_impact	-1.11	low_impact	0.57	0.8	25.7	14.61	0.35	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	COSM6716787	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13787	13787	T	G	MI.22357	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1451	484	L	R	cTc/cGc	-6.94	0	0	possibly_damaging	0.59	neutral	0.35	neutral	0.76	deleterious	-3.47	neutral	-2.25	medium_impact	2.52	0.7	neutral	0.48	neutral	2.68	20.70	deleterious	0.3	0.45	NA	NA	0.75	disease	0.57	disease	0.72	disease	4	0.67	neutral	0.38	neutral	0	NA	0.77	deleterious	-0.9	medium_impact	0.08	medium_impact	1.1	medium_impact	0.65	0.8	25.7	14.61	0.3	N	0.31	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13787	13787	T	A	MI.22358	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1451	484	L	H	cTc/cAc	-6.94	0	0	benign	0.02	neutral	0.54	neutral	0.76	deleterious	-3.55	neutral	-1.77	low_impact	1.28	0.85	neutral	0.98	neutral	2.17	17.30	deleterious	0.29	0.45	NA	NA	0.48	neutral	0.38	neutral	0.32	neutral	4	0.44	neutral	0.76	deleterious	-6	neutral	0.71	deleterious	0.86	medium_impact	0.27	medium_impact	-0.03	medium_impact	0.68	0.85	25.7	14.61	0.3	N	0.04	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13789	13789	T	A	MI.22359	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1453	485	Y	N	Tac/Aac	-20	0	0.01	probably_damaging	0.92	neutral	0.36	neutral	0.9	neutral	-1.45	deleterious	-5.69	low_impact	1.7	0.81	neutral	0.62	neutral	2.98	22.20	deleterious	0.44	0.55	0.64	disease	0.49	neutral	0.51	disease	0.57	disease	1	0.93	neutral	0.22	neutral	-2	neutral	0.75	deleterious	-1.75	low_impact	0.1	medium_impact	0.35	medium_impact	0.33	0.8	19.57	16.38	0.32	N	0.76	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6073	6073	T	G	MI.2236	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	170	57	I	S	aTc/aGc	-0.11	0	0	possibly_damaging	0.62	deleterious	0	neutral	2.66	neutral	-1.42	deleterious	-3.47	medium_impact	2.9	0.63	neutral	0.13	damaging	3.72	23.30	deleterious	0.17	0.55	0.52	disease	0.89	disease	0.57	disease	0.75	disease	5	1	deleterious	0.19	neutral	4	deleterious	0.55	deleterious	-0.96	medium_impact	-1.48	low_impact	1.58	medium_impact	0.56	0.9	5.26	53.05	0.27	N	0.71	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13789	13789	T	G	MI.22360	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1453	485	Y	D	Tac/Gac	-20	0	0.01	probably_damaging	0.97	neutral	0.19	neutral	0.87	neutral	-2.35	deleterious	-6.77	medium_impact	2.25	0.76	neutral	0.44	neutral	3.94	23.50	deleterious	0.37	0.5	0.67	disease	0.61	disease	0.63	disease	0.73	disease	5	0.98	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-2.18	low_impact	-0.12	medium_impact	0.85	medium_impact	0.45	0.8	19.57	16.38	0.34	N	0.88	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13789	13789	T	C	MI.22361	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1453	485	Y	H	Tac/Cac	-20	0	0.01	benign	0.17	neutral	0.5	neutral	0.87	neutral	-2.46	neutral	-1.8	neutral_impact	0.12	0.84	neutral	0.98	neutral	2.06	16.59	deleterious	0.55	0.6	0.53	disease	0.3	neutral	0.45	neutral	0.36	neutral	3	0.4	neutral	0.67	deleterious	-6	neutral	0.71	deleterious	-0.09	medium_impact	0.23	medium_impact	-1.09	low_impact	0.32	0.8	19.57	16.38	0.28	N	0.39	polymorphism	1	0.07	rs28359179	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13790	13790	A	T	MI.22362	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1454	485	Y	F	tAc/tTc	-4.87	0	0	probably_damaging	0.92	neutral	0.72	neutral	0.97	neutral	-0.31	deleterious	-3.18	neutral_impact	0.66	0.83	neutral	0.87	neutral	2.74	21.10	deleterious	0.5	0.6	0.41	neutral	0.3	neutral	0.34	neutral	0.44	neutral	1	0.91	neutral	0.4	neutral	-2	neutral	0.69	deleterious	-1.75	low_impact	0.46	medium_impact	-0.6	medium_impact	0.31	0.8	19.57	16.38	0.23	N	0.25	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13790	13790	A	G	MI.22363	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1454	485	Y	C	tAc/tGc	-4.87	0	0	probably_damaging	0.99	neutral	0.15	neutral	0.85	deleterious	-3.35	deleterious	-6.7	medium_impact	2.25	0.76	neutral	0.38	neutral	4.09	23.70	deleterious	0.36	0.5	0.8	disease	0.61	disease	0.54	disease	0.67	disease	3	0.99	deleterious	0.08	neutral	1	deleterious	0.77	deleterious	-2.64	low_impact	-0.18	medium_impact	0.85	medium_impact	0.13	0.8	19.57	16.38	0.28	N	0.82	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13790	13790	A	C	MI.22364	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1454	485	Y	S	tAc/tCc	-4.87	0	0	probably_damaging	0.96	neutral	0.45	neutral	0.93	neutral	-0.77	deleterious	-6.08	neutral_impact	0.38	0.85	neutral	0.9	neutral	2.92	21.90	deleterious	0.35	0.5	0.47	neutral	0.29	neutral	0.43	neutral	0.44	neutral	1	0.96	neutral	0.25	neutral	-2	neutral	0.71	deleterious	-2.06	low_impact	0.18	medium_impact	-0.86	medium_impact	0.37	0.8	19.57	16.38	0.33	N	0.79	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13792	13792	C	A	MI.22365	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1456	486	L	M	Cta/Ata	-6.71	0	0	probably_damaging	0.98	neutral	0.53	neutral	0.68	neutral	-2	neutral	-1.22	neutral_impact	0.79	0.8	neutral	0.94	neutral	2.83	21.50	deleterious	0.4	0.5	NA	NA	0.25	neutral	0.34	neutral	0.18	neutral	6	0.98	deleterious	0.28	neutral	-2	neutral	0.71	deleterious	-2.35	low_impact	0.26	medium_impact	-0.48	medium_impact	0.78	0.85	15.59	14.45	0.27	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13792	13792	C	G	MI.22366	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1456	486	L	V	Cta/Gta	-6.71	0	0	possibly_damaging	0.76	neutral	0.51	neutral	0.69	neutral	-1.96	neutral	-2.02	medium_impact	2.15	0.75	neutral	0.32	neutral	3.47	23.00	deleterious	0.47	0.55	NA	NA	0.46	neutral	0.58	disease	0.41	neutral	2	0.74	neutral	0.38	neutral	0	NA	0.75	deleterious	-1.22	low_impact	0.24	medium_impact	0.76	medium_impact	0.53	0.8	15.59	14.45	0.26	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13793	13793	T	A	MI.22367	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1457	486	L	Q	cTa/cAa	-3.04	0	0	probably_damaging	1	neutral	0.27	neutral	0.6	deleterious	-3.69	deleterious	-4.87	medium_impact	2.95	0.71	neutral	0.14	damaging	4.22	23.90	deleterious	0.32	0.5	NA	NA	0.77	disease	0.59	disease	0.71	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.01	medium_impact	1.49	medium_impact	0.63	0.8	15.59	14.45	0.3	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13793	13793	T	G	MI.22368	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1457	486	L	R	cTa/cGa	-3.04	0	0	probably_damaging	1	neutral	0.31	neutral	0.59	deleterious	-4.17	deleterious	-4.96	medium_impact	2.95	0.65	neutral	0.1	damaging	4.27	24.00	deleterious	0.33	0.5	NA	NA	0.88	disease	0.72	disease	0.79	disease	6	1	deleterious	0.16	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	0.04	medium_impact	1.49	medium_impact	0.51	0.8	15.59	14.45	0.26	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13793	13793	T	C	MI.22369	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1457	486	L	P	cTa/cCa	-3.04	0	0	probably_damaging	1	neutral	0.23	neutral	0.58	deleterious	-4.87	deleterious	-5.73	medium_impact	2.95	0.63	neutral	0.14	damaging	4.02	23.60	deleterious	0.26	0.45	NA	NA	0.86	disease	0.72	disease	0.78	disease	6	1	deleterious	0.12	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	-0.06	medium_impact	1.49	medium_impact	0.55	0.8	15.59	14.45	0.24	N	0.89	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6073	6073	T	A	MI.2237	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	170	57	I	N	aTc/aAc	-0.11	0	0	possibly_damaging	0.88	deleterious	0	neutral	2.6	deleterious	-3.38	deleterious	-4.1	high_impact	4.53	0.59	damaging	0.11	damaging	4.11	23.70	deleterious	0.13	0.55	0.68	disease	0.87	disease	0.61	disease	0.74	disease	5	1	deleterious	0.06	neutral	5	deleterious	0.78	deleterious	-1.57	low_impact	-1.48	low_impact	3.08	high_impact	0.64	0.9	5.26	53.05	0.43	N	0.82	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13795	13795	A	G	MI.22370	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1459	487	K	E	Aaa/Gaa	-4.64	0	0	probably_damaging	1	neutral	0.29	neutral	-0.23	deleterious	-5.15	deleterious	-3.59	high_impact	3.93	0.54	damaging	0.13	damaging	4.12	23.80	deleterious	0.42	0.5	0.46	neutral	0.86	disease	0.79	disease	0.8	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.02	medium_impact	2.39	high_impact	0.58	0.8	27.86	7.2	0.42	N	0.84	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13795	13795	A	C	MI.22371	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1459	487	K	Q	Aaa/Caa	-4.64	0	0	probably_damaging	1	neutral	0.3	neutral	-0.24	deleterious	-5.38	deleterious	-3.59	high_impact	3.93	0.5	damaging	0.11	damaging	3.57	23.10	deleterious	0.44	0.55	0.55	disease	0.83	disease	0.76	disease	0.78	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.03	medium_impact	2.39	high_impact	0.60	0.8	27.86	7.2	0.38	N	0.82	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13796	13796	A	C	MI.22372	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1460	487	K	T	aAa/aCa	8.42	1	0	probably_damaging	1	neutral	0.57	neutral	-0.24	deleterious	-5.25	deleterious	-5.39	high_impact	3.93	0.48	damaging	0.14	damaging	3.69	23.30	deleterious	0.29	0.45	0.61	disease	0.79	disease	0.76	disease	0.77	disease	5	1	deleterious	0.29	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.3	medium_impact	2.39	high_impact	0.51	0.8	27.86	7.2	0.58	P	0.75	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13796	13796	A	T	MI.22373	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1460	487	K	M	aAa/aTa	8.42	1	0	probably_damaging	1	neutral	0.27	neutral	-0.28	deleterious	-7.72	deleterious	-5.39	high_impact	3.93	0.54	damaging	0.09	damaging	3.92	23.50	deleterious	0.26	0.45	0.57	disease	0.84	disease	0.76	disease	0.8	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	-0.01	medium_impact	2.39	high_impact	0.41	0.8	27.86	7.2	0.52	P	0.40	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13797	13797	A	T	MI.22374	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1461	487	K	N	aaA/aaT	8.42	1	0	probably_damaging	1	neutral	0.37	neutral	-0.23	deleterious	-5.03	deleterious	-4.49	high_impact	3.93	0.56	damaging	0.09	damaging	3.94	23.50	deleterious	0.55	0.6	0.63	disease	0.84	disease	0.77	disease	0.8	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.11	medium_impact	2.39	high_impact	0.58	0.8	27.86	7.2	0.62	P	0.63	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13797	13797	A	C	MI.22375	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1461	487	K	N	aaA/aaC	8.42	1	0	probably_damaging	1	neutral	0.37	neutral	-0.23	deleterious	-5.03	deleterious	-4.49	high_impact	3.93	0.56	damaging	0.09	damaging	3.89	23.50	deleterious	0.55	0.6	0.63	disease	0.84	disease	0.77	disease	0.8	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.11	medium_impact	2.39	high_impact	0.58	0.8	27.86	7.2	0.6	P	0.63	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13798	13798	C	A	MI.22376	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1462	488	L	I	Ctc/Atc	3.15	0.99	0	possibly_damaging	0.66	neutral	0.44	neutral	0.78	neutral	-1.42	neutral	-1.1	low_impact	1.72	0.78	neutral	0.94	neutral	3.22	22.70	deleterious	0.44	0.55	0.33	neutral	0.33	neutral	0.3	neutral	0.47	neutral	1	0.66	neutral	0.39	neutral	-3	neutral	0.68	deleterious	-1.02	low_impact	0.18	medium_impact	0.37	medium_impact	0.74	0.85	10.45	11.49	0.48	N	0.29	disease_causing	0.59	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13798	13798	C	T	MI.22377	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1462	488	L	F	Ctc/Ttc	3.15	0.99	0	benign	0.12	neutral	0.73	neutral	0.7	neutral	-2.56	neutral	-1.72	medium_impact	2.9	0.83	neutral	0.94	neutral	2.97	22.10	deleterious	0.49	0.55	0.6	disease	0.62	disease	0.49	neutral	0.51	disease	0	0.16	neutral	0.81	deleterious	-3	neutral	0.75	deleterious	0.08	medium_impact	0.47	medium_impact	1.45	medium_impact	0.63	0.8	10.45	11.49	0.43	N	0.29	disease_causing	0.93	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13798	13798	C	G	MI.22378	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1462	488	L	V	Ctc/Gtc	3.15	0.99	0	possibly_damaging	0.66	neutral	0.56	neutral	0.78	neutral	-1.43	neutral	-1.63	medium_impact	2.48	0.82	neutral	0.8	neutral	3.49	23.10	deleterious	0.44	0.55	0.36	neutral	0.48	neutral	0.36	neutral	0.48	neutral	1	0.61	neutral	0.45	neutral	0	NA	0.69	deleterious	-1.02	low_impact	0.29	medium_impact	1.06	medium_impact	0.62	0.8	10.45	11.49	0.38	N	0.30	disease_causing	0.72	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13799	13799	T	A	MI.22379	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1463	488	L	H	cTc/cAc	-3.96	0	0	benign	0.18	neutral	0.52	neutral	0.64	deleterious	-4.59	deleterious	-4.29	medium_impact	3.44	0.74	neutral	0.47	neutral	4.36	24.10	deleterious	0.24	0.45	0.72	disease	0.77	disease	0.66	disease	0.72	disease	4	0.38	neutral	0.67	deleterious	-3	neutral	0.80	deleterious	-0.12	medium_impact	0.25	medium_impact	1.94	medium_impact	0.69	0.85	10.45	11.49	0.27	N	0.77	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6074	6074	C	G	MI.2238	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	171	57	I	M	atC/atG	7.53	0.97	0	possibly_damaging	0.79	neutral	0.07	neutral	2.66	neutral	-1.43	neutral	-1.46	low_impact	1.7	0.63	neutral	0.19	damaging	2.93	22.00	deleterious	0.29	0.55	0.46	neutral	0.57	disease	0.34	neutral	0.48	neutral	1	0.95	neutral	0.14	neutral	-3	neutral	0.60	deleterious	-1.3	low_impact	-0.43	medium_impact	0.47	medium_impact	0.82	0.9	5.26	53.05	0.52	P	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13799	13799	T	G	MI.22380	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1463	488	L	R	cTc/cGc	-3.96	0	0	probably_damaging	0.91	neutral	0.34	neutral	0.65	deleterious	-4.04	deleterious	-3.86	medium_impact	3.44	0.67	neutral	0.41	neutral	4.34	24.00	deleterious	0.16	0.45	0.65	disease	0.88	disease	0.7	disease	0.78	disease	6	0.92	neutral	0.22	neutral	1	deleterious	0.85	deleterious	-1.7	low_impact	0.07	medium_impact	1.94	medium_impact	0.73	0.85	10.45	11.49	0.3	N	0.62	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13799	13799	T	C	MI.22381	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1463	488	L	P	cTc/cCc	-3.96	0	0	probably_damaging	0.95	neutral	0.29	neutral	0.64	deleterious	-4.64	deleterious	-4.61	medium_impact	3.44	0.61	neutral	0.37	neutral	4.08	23.70	deleterious	0.15	0.4	0.7	disease	0.87	disease	0.71	disease	0.79	disease	6	0.96	neutral	0.17	neutral	1	deleterious	0.86	deleterious	-1.96	low_impact	0.02	medium_impact	1.94	medium_impact	0.60	0.8	10.45	11.49	0.29	N	0.90	disease_causing	0.86	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13801	13801	A	T	MI.22382	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1465	489	T	S	Aca/Tca	-12.67	0	0	benign	0.03	neutral	0.43	neutral	0.98	neutral	-0.29	neutral	-1.56	neutral_impact	0.34	0.89	neutral	0.96	neutral	-0.24	0.89	neutral	0.54	0.6	0.31	neutral	0.29	neutral	0.27	neutral	0.44	neutral	1	0.54	neutral	0.7	deleterious	-6	neutral	0.45	deleterious	0.69	medium_impact	0.17	medium_impact	-0.89	medium_impact	0.75	0.85	19.57	15.11	0.47	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13801	13801	A	G	MI.22383	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1465	489	T	A	Aca/Gca	-12.67	0	0	benign	0.01	neutral	0.53	neutral	1.08	neutral	0.68	neutral	-2.31	neutral_impact	0.04	0.76	neutral	0.92	neutral	-0.89	0.03	neutral	0.58	0.65	0.35	neutral	0.08	neutral	0.26	neutral	0.21	neutral	6	0.46	neutral	0.76	deleterious	-6	neutral	0.13	neutral	1.15	medium_impact	0.26	medium_impact	-1.17	low_impact	0.49	0.8	19.57	15.11	0.41	N	0.06	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13801	13801	A	C	MI.22384	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1465	489	T	P	Aca/Cca	-12.67	0	0	possibly_damaging	0.66	neutral	0.26	neutral	0.88	neutral	-2.97	deleterious	-3.63	medium_impact	2.77	0.62	neutral	0.31	neutral	3.48	23.10	deleterious	0.22	0.45	0.8	disease	0.88	disease	0.69	disease	0.82	disease	6	0.78	neutral	0.3	neutral	0	NA	0.84	deleterious	-1.02	low_impact	-0.02	medium_impact	1.33	medium_impact	0.75	0.85	19.57	15.11	0.28	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13802	13802	C	A	MI.22385	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1466	489	T	K	aCa/aAa	-1.44	0	0	benign	0.37	neutral	0.31	neutral	0.91	neutral	-1.47	deleterious	-3.31	medium_impact	2.77	0.76	neutral	0.41	neutral	4.31	24.00	deleterious	0.25	0.45	0.65	disease	0.81	disease	0.65	disease	0.78	disease	6	0.63	neutral	0.47	deleterious	-3	neutral	0.71	deleterious	-0.53	medium_impact	0.04	medium_impact	1.33	medium_impact	0.75	0.85	19.57	15.11	0.28	N	0.67	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13802	13802	C	T	MI.22386	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1466	489	T	M	aCa/aTa	-1.44	0	0	benign	0.12	neutral	0.23	neutral	1.02	neutral	0.16	neutral	-2.46	low_impact	1.1	0.83	neutral	0.98	neutral	2.77	21.20	deleterious	0.38	0.5	0.66	disease	0.54	disease	0.34	neutral	0.51	disease	0	0.74	neutral	0.56	deleterious	-6	neutral	0.73	deleterious	0.08	medium_impact	-0.06	medium_impact	-0.2	medium_impact	0.75	0.85	19.57	15.11	0.36	N	0.80	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13804	13804	G	A	MI.22387	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1468	490	A	T	Gcc/Acc	-7.17	0	0	probably_damaging	1	neutral	0.43	neutral	0.66	neutral	-1.65	deleterious	-3.02	medium_impact	2.1	0.65	neutral	0.65	neutral	4.28	24.00	deleterious	0.48	0.55	0.5	neutral	0.75	disease	0.54	disease	0.51	disease	0	1	deleterious	0.22	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.17	medium_impact	0.72	medium_impact	0.74	0.85	9.95	7.25	0.27	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13804	13804	G	T	MI.22388	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1468	490	A	S	Gcc/Tcc	-7.17	0	0	probably_damaging	1	neutral	0.49	neutral	0.53	deleterious	-3.28	neutral	-2.44	medium_impact	3.46	0.7	neutral	0.44	neutral	3.81	23.40	deleterious	0.39	0.5	0.43	neutral	0.83	disease	0.61	disease	0.71	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.22	medium_impact	1.96	medium_impact	0.92	0.95	9.95	7.25	0.29	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13804	13804	G	C	MI.22389	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1468	490	A	P	Gcc/Ccc	-7.17	0	0	probably_damaging	1	neutral	0.27	neutral	0.55	neutral	-2.97	deleterious	-4.24	medium_impact	2.7	0.58	damaging	0.61	neutral	3.96	23.60	deleterious	0.1	0.4	0.53	disease	0.85	disease	0.68	disease	0.53	disease	1	1	deleterious	0.14	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.01	medium_impact	1.26	medium_impact	0.83	0.85	9.95	7.25	0.31	N	0.96	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6074	6074	C	A	MI.2239	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	171	57	I	M	atC/atA	7.53	0.97	0	possibly_damaging	0.79	neutral	0.07	neutral	2.66	neutral	-1.43	neutral	-1.46	low_impact	1.7	0.63	neutral	0.19	damaging	3.44	23.00	deleterious	0.29	0.55	0.46	neutral	0.57	disease	0.34	neutral	0.48	neutral	1	0.95	neutral	0.14	neutral	-3	neutral	0.60	deleterious	-1.3	low_impact	-0.43	medium_impact	0.47	medium_impact	0.82	0.9	5.26	53.05	0.53	P	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13805	13805	C	G	MI.22390	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1469	490	A	G	gCc/gGc	4.06	1	0	probably_damaging	1	neutral	0.36	neutral	0.54	deleterious	-3.25	deleterious	-3.47	high_impact	3.8	0.69	neutral	0.54	neutral	4.09	23.70	deleterious	0.26	0.45	0.69	disease	0.8	disease	0.63	disease	0.65	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.1	medium_impact	2.27	high_impact	0.87	0.9	9.95	7.25	0.5	N	0.82	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13805	13805	C	A	MI.22391	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1469	490	A	D	gCc/gAc	4.06	1	0	probably_damaging	1	neutral	0.2	neutral	0.5	deleterious	-4.57	deleterious	-5.07	high_impact	3.8	0.66	neutral	0.41	neutral	4.74	24.70	deleterious	0.12	0.4	0.59	disease	0.93	disease	0.74	disease	0.82	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.1	medium_impact	2.27	high_impact	0.77	0.85	9.95	7.25	0.51	P	0.95	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13805	13805	C	T	MI.22392	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1469	490	A	V	gCc/gTc	4.06	1	0	probably_damaging	1	neutral	0.56	neutral	0.59	neutral	-2.3	deleterious	-3.34	high_impact	3.8	0.66	neutral	0.47	neutral	4.56	24.40	deleterious	0.35	0.5	0.59	disease	0.84	disease	0.6	disease	0.72	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.29	medium_impact	2.27	high_impact	0.85	0.9	9.95	7.25	0.48	N	0.76	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13807	13807	C	G	MI.22393	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1471	491	L	V	Ctc/Gtc	-7.4	0	0	probably_damaging	1	neutral	0.51	neutral	0.5	neutral	-2.43	neutral	-2.04	medium_impact	2.66	0.81	neutral	0.68	neutral	3.51	23.10	deleterious	0.35	0.5	0.52	disease	0.51	disease	0.43	neutral	0.46	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.24	medium_impact	1.23	medium_impact	0.73	0.85	3.98	8.23	0.27	N	0.81	polymorphism	0.85	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13807	13807	C	A	MI.22394	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1471	491	L	I	Ctc/Atc	-7.4	0	0	probably_damaging	1	neutral	0.47	neutral	0.56	neutral	-1.93	neutral	-1.27	low_impact	1.2	0.8	neutral	0.91	neutral	3.09	22.50	deleterious	0.32	0.5	0.4	neutral	0.25	neutral	0.36	neutral	0.43	neutral	2	1	deleterious	0.24	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.2	medium_impact	-0.11	medium_impact	0.79	0.85	3.98	8.23	0.33	N	0.85	polymorphism	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13807	13807	C	T	MI.22395	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1471	491	L	F	Ctc/Ttc	-7.4	0	0	probably_damaging	1	neutral	0.77	neutral	0.43	deleterious	-3.38	deleterious	-3.17	medium_impact	2.94	0.73	neutral	0.42	neutral	4.08	23.70	deleterious	0.37	0.5	0.61	disease	0.68	disease	0.63	disease	0.62	disease	2	1	deleterious	0.39	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.52	medium_impact	1.48	medium_impact	0.75	0.85	3.98	8.23	0.19	N	0.99	polymorphism	0.54	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13808	13808	T	G	MI.22396	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1472	491	L	R	cTc/cGc	-0.98	0	0	probably_damaging	1	neutral	0.31	neutral	0.38	deleterious	-5.02	deleterious	-4.98	high_impact	3.63	0.58	damaging	0.26	damaging	4.31	24.00	deleterious	0.08	0.35	0.78	disease	0.9	disease	0.75	disease	0.84	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.04	medium_impact	2.11	high_impact	0.78	0.85	3.98	8.23	0.33	N	1.00	disease_causing	0.56	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13808	13808	T	C	MI.22397	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1472	491	L	P	cTc/cCc	-0.98	0	0	probably_damaging	1	neutral	0.21	neutral	0.39	deleterious	-4.63	deleterious	-5.72	medium_impact	3.29	0.61	neutral	0.25	damaging	4.02	23.60	deleterious	0.1	0.4	0.58	disease	0.86	disease	0.75	disease	0.81	disease	6	1	deleterious	0.11	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	-0.09	medium_impact	1.8	medium_impact	0.66	0.8	3.98	8.23	0.3	N	0.99	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13808	13808	T	A	MI.22398	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1472	491	L	H	cTc/cAc	-0.98	0	0	probably_damaging	1	neutral	0.44	neutral	0.38	deleterious	-5.59	deleterious	-5.75	high_impact	3.63	0.69	neutral	0.31	neutral	4.25	23.90	deleterious	0.13	0.4	0.59	disease	0.81	disease	0.72	disease	0.75	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.18	medium_impact	2.11	high_impact	0.68	0.85	3.98	8.23	0.25	N	0.97	polymorphism	0.59	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13810	13810	G	C	MI.22399	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1474	492	A	P	Gct/Cct	-13.58	0	0	benign	0.29	neutral	0.23	neutral	0.9	neutral	-2.8	neutral	-2.25	low_impact	1.45	0.72	neutral	0.4	neutral	2.20	17.54	deleterious	0.09	0.35	0.82	disease	0.82	disease	0.63	disease	0.79	disease	6	0.72	neutral	0.47	deleterious	-6	neutral	0.65	deleterious	-0.38	medium_impact	-0.06	medium_impact	0.12	medium_impact	0.86	0.9	27.36	18.4	0.26	N	0.65	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8632	8632	T	G	MI.224	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	106	36	Y	D	Tat/Gat	-10.05	0	0	benign	0.17	neutral	0.19	neutral	4.44	neutral	1.74	neutral	-1.53	low_impact	1.05	0.9	neutral	0.49	neutral	2.09	16.81	deleterious	0.52	0.65	0.4	neutral	0.63	disease	0.54	disease	0.64	disease	3	0.78	neutral	0.51	deleterious	-6	neutral	0.27	neutral	-0.1	medium_impact	-0.06	medium_impact	-0.2	medium_impact	0.48	0.9	29.2	23.72	0.38	N	0.24	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6075	6075	G	C	MI.2240	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	172	58	V	L	Gtc/Ctc	-4.5	0	0	benign	0.04	neutral	0.05	neutral	2.9	neutral	0.61	neutral	-1.79	high_impact	3.6	0.61	neutral	0.53	neutral	1.49	13.25	neutral	0.23	0.55	0.24	neutral	0.83	disease	0.5	neutral	0.7	disease	4	0.95	neutral	0.51	deleterious	-2	neutral	0.26	neutral	0.54	medium_impact	-0.52	medium_impact	2.23	high_impact	0.74	0.9	1.75	6.95	0.44	N	0.55	polymorphism	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13810	13810	G	T	MI.22400	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1474	492	A	S	Gct/Tct	-13.58	0	0	benign	0.01	neutral	0.48	neutral	0.94	neutral	-1.07	neutral	-0.7	neutral_impact	-0.08	0.91	neutral	0.82	neutral	0.49	7.34	deleterious	0.36	0.5	0.65	disease	0.36	neutral	0.38	neutral	0.61	disease	2	0.51	neutral	0.74	deleterious	-6	neutral	0.18	neutral	1.15	medium_impact	0.21	medium_impact	-1.28	low_impact	0.87	0.9	27.36	18.4	0.33	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13810	13810	G	A	MI.22401	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1474	492	A	T	Gct/Act	-13.58	0	0	benign	0.01	neutral	0.52	neutral	1.01	neutral	0.07	neutral	-0.26	neutral_impact	-0.79	0.88	neutral	0.99	neutral	0.32	5.84	deleterious	0.45	0.55	0.55	disease	0.17	neutral	0.25	neutral	0.37	neutral	3	0.46	neutral	0.76	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.25	medium_impact	-1.92	low_impact	0.71	0.85	27.36	18.4	0.39	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13811	13811	C	G	MI.22402	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1475	492	A	G	gCt/gGt	-14.73	0	0	benign	0	neutral	0.44	neutral	0.92	neutral	-1.85	neutral	-2.03	neutral_impact	0.64	0.91	neutral	0.8	neutral	0.94	10.32	neutral	0.18	0.45	0.63	disease	0.42	neutral	0.38	neutral	0.6	disease	2	0.56	neutral	0.72	deleterious	-6	neutral	0.17	neutral	2.1	high_impact	0.18	medium_impact	-0.62	medium_impact	0.83	0.85	27.36	18.4	0.34	N	0.12	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13811	13811	C	A	MI.22403	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1475	492	A	D	gCt/gAt	-14.73	0	0	benign	0.11	neutral	0.21	neutral	0.9	deleterious	-3.39	deleterious	-2.62	low_impact	1.45	0.77	neutral	0.41	neutral	2.71	20.80	deleterious	0.11	0.4	0.72	disease	0.77	disease	0.63	disease	0.77	disease	5	0.76	neutral	0.55	deleterious	-6	neutral	0.51	deleterious	0.12	medium_impact	-0.09	medium_impact	0.12	medium_impact	0.77	0.85	27.36	18.4	0.27	N	0.55	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13811	13811	C	T	MI.22404	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1475	492	A	V	gCt/gTt	-14.73	0	0	benign	0.11	neutral	0.54	neutral	1.05	neutral	0.54	neutral	-0.25	neutral_impact	0.2	0.86	neutral	0.95	neutral	1.24	11.98	neutral	0.35	0.5	0.29	neutral	0.35	neutral	0.31	neutral	0.45	neutral	1	0.37	neutral	0.72	deleterious	-6	neutral	0.25	neutral	0.12	medium_impact	0.27	medium_impact	-1.02	low_impact	0.73	0.85	27.36	18.4	0.33	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13813	13813	G	C	MI.22405	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1477	493	V	L	Gtc/Ctc	-20	0	0	benign	0.12	neutral	0.82	neutral	0.62	neutral	-1.86	neutral	-1.94	low_impact	1.66	0.76	neutral	0.68	neutral	1.79	14.95	neutral	0.44	0.55	0.55	disease	0.8	disease	0.51	disease	0.54	disease	1	0.08	neutral	0.85	deleterious	-6	neutral	0.23	neutral	0.08	medium_impact	0.6	medium_impact	0.31	medium_impact	0.76	0.85	10.45	10.12	0.22	N	0.53	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13813	13813	G	A	MI.22406	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1477	493	V	I	Gtc/Atc	-20	0	0	benign	0.01	neutral	0.48	neutral	0.58	neutral	-2.22	neutral	-0.37	neutral_impact	0.74	0.82	neutral	0.94	neutral	0.43	6.86	deleterious	0.5	0.6	0.44	neutral	0.32	neutral	0.4	neutral	0.43	neutral	1	0.51	neutral	0.74	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.21	medium_impact	-0.53	medium_impact	0.78	0.85	10.45	10.12	0.39	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13813	13813	G	T	MI.22407	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1477	493	V	F	Gtc/Ttc	-20	0	0	possibly_damaging	0.5	neutral	0.78	neutral	0.52	deleterious	-3.15	deleterious	-3.68	medium_impact	2.55	0.73	neutral	0.66	neutral	2.29	18.11	deleterious	0.2	0.45	0.59	disease	0.89	disease	0.65	disease	0.57	disease	1	0.39	neutral	0.64	deleterious	0	NA	0.55	deleterious	-0.75	medium_impact	0.54	medium_impact	1.13	medium_impact	0.68	0.85	10.45	10.12	0.24	N	0.77	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13814	13814	T	C	MI.22408	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1478	493	V	A	gTc/gCc	-0.29	0	0	benign	0.01	neutral	0.62	neutral	0.56	neutral	-2.48	deleterious	-3.23	low_impact	1.94	0.81	neutral	0.76	neutral	1.66	14.19	neutral	0.3	0.45	0.56	disease	0.56	disease	0.56	disease	0.5	disease	0	0.37	neutral	0.81	deleterious	-6	neutral	0.19	neutral	1.15	medium_impact	0.35	medium_impact	0.57	medium_impact	0.41	0.8	10.45	10.12	0.26	N	0.06	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13814	13814	T	A	MI.22409	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1478	493	V	D	gTc/gAc	-0.29	0	0	possibly_damaging	0.55	neutral	0.24	neutral	0.46	deleterious	-5.96	deleterious	-5.57	medium_impact	3.35	0.68	neutral	0.37	neutral	4.22	23.90	deleterious	0.08	0.35	0.89	disease	0.93	disease	0.75	disease	0.86	disease	7	0.75	neutral	0.35	neutral	0	NA	0.76	deleterious	-0.83	medium_impact	-0.04	medium_impact	1.86	medium_impact	0.59	0.8	10.45	10.12	0.3	N	0.92	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6075	6075	G	A	MI.2241	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	172	58	V	I	Gtc/Atc	-4.5	0	0	benign	0.01	neutral	0.24	neutral	2.73	neutral	-0.83	neutral	-0.52	low_impact	1.75	0.55	damaging	0.6	neutral	0.39	6.54	deleterious	0.3	0.55	0.31	neutral	0.5	neutral	0.37	neutral	0.44	neutral	1	0.76	neutral	0.62	deleterious	-6	neutral	0.21	neutral	1.12	medium_impact	-0.09	medium_impact	0.52	medium_impact	0.68	0.9	1.75	6.95	0.47	N	0.24	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13814	13814	T	G	MI.22410	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1478	493	V	G	gTc/gGc	-0.29	0	0	benign	0.01	neutral	0.39	neutral	0.47	deleterious	-4.86	deleterious	-5.83	medium_impact	2.66	0.69	neutral	0.61	neutral	2.13	17.03	deleterious	0.17	0.45	0.7	disease	0.87	disease	0.63	disease	0.74	disease	5	0.6	neutral	0.69	deleterious	-3	neutral	0.49	deleterious	1.15	medium_impact	0.13	medium_impact	1.23	medium_impact	0.51	0.8	10.45	10.12	0.28	N	0.90	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13816	13816	A	C	MI.22411	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1480	494	T	P	Act/Cct	-13.81	0	0	probably_damaging	0.98	neutral	0.26	neutral	0.71	deleterious	-3.05	deleterious	-5.26	high_impact	3.68	0.66	neutral	0.3	neutral	3.59	23.20	deleterious	0.14	0.4	0.82	disease	0.9	disease	0.74	disease	0.82	disease	6	0.98	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	-0.02	medium_impact	2.16	high_impact	0.76	0.85	4.15	9.95	0.31	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13816	13816	A	T	MI.22412	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1480	494	T	S	Act/Tct	-13.81	0	0	possibly_damaging	0.81	neutral	0.54	neutral	0.83	neutral	-1.13	deleterious	-3.38	low_impact	1.64	0.72	neutral	0.88	neutral	2.33	18.34	deleterious	0.47	0.55	0.41	neutral	0.49	neutral	0.38	neutral	0.45	neutral	1	0.79	neutral	0.37	neutral	-3	neutral	0.72	deleterious	-1.34	low_impact	0.27	medium_impact	0.3	medium_impact	0.80	0.85	4.15	9.95	0.33	N	0.52	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13816	13816	A	G	MI.22413	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1480	494	T	A	Act/Gct	-13.81	0	0	benign	0.12	neutral	0.63	neutral	0.74	neutral	-2.2	deleterious	-4.34	medium_impact	2.78	0.74	neutral	0.76	neutral	3.62	23.20	deleterious	0.62	0.65	0.39	neutral	0.63	disease	0.58	disease	0.49	neutral	0	0.27	neutral	0.76	deleterious	-3	neutral	0.73	deleterious	0.08	medium_impact	0.36	medium_impact	1.34	medium_impact	0.62	0.8	4.15	9.95	0.33	N	0.83	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13817	13817	C	A	MI.22414	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1481	494	T	N	aCt/aAt	2.69	0.93	0	probably_damaging	0.97	neutral	0.33	neutral	0.69	deleterious	-3.93	deleterious	-4.3	high_impact	3.68	0.73	neutral	0.45	neutral	3.76	23.30	deleterious	0.37	0.5	0.7	disease	0.88	disease	0.63	disease	0.74	disease	5	0.97	neutral	0.18	neutral	2	deleterious	0.82	deleterious	-2.18	low_impact	0.06	medium_impact	2.16	high_impact	0.80	0.85	4.15	9.95	0.41	N	0.88	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13817	13817	C	G	MI.22415	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1481	494	T	S	aCt/aGt	2.69	0.93	0	possibly_damaging	0.81	neutral	0.54	neutral	0.83	neutral	-1.13	deleterious	-3.38	low_impact	1.64	0.72	neutral	0.88	neutral	2.56	19.84	deleterious	0.47	0.55	0.41	neutral	0.49	neutral	0.38	neutral	0.45	neutral	1	0.79	neutral	0.37	neutral	-3	neutral	0.72	deleterious	-1.34	low_impact	0.27	medium_impact	0.3	medium_impact	0.80	0.85	4.15	9.95	0.34	N	0.52	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13817	13817	C	T	MI.22416	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1481	494	T	I	aCt/aTt	2.69	0.93	0	possibly_damaging	0.82	neutral	0.48	neutral	0.79	neutral	-1.58	deleterious	-5.29	medium_impact	2.88	0.72	neutral	0.66	neutral	4.02	23.60	deleterious	0.4	0.5	0.63	disease	0.84	disease	0.59	disease	0.69	disease	4	0.8	neutral	0.33	neutral	0	NA	0.80	deleterious	-1.37	low_impact	0.21	medium_impact	1.43	medium_impact	0.84	0.9	4.15	9.95	0.33	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13819	13819	T	A	MI.22417	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1483	495	F	I	Ttc/Atc	-5.56	0	0.01	benign	0	neutral	0.54	neutral	1.28	neutral	2.01	neutral	2.47	neutral_impact	-2.39	0.84	neutral	0.98	neutral	-0.12	1.57	neutral	0.26	0.45	0.26	neutral	0.07	neutral	0.19	neutral	0.27	neutral	5	0.45	neutral	0.77	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.27	medium_impact	-3.39	low_impact	0.68	0.85	11.61	10.25	0.42	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13819	13819	T	C	MI.22418	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1483	495	F	L	Ttc/Ctc	-5.56	0	0.01	benign	0	neutral	0.98	neutral	1.17	neutral	1.48	neutral	1.89	neutral_impact	-1.96	0.86	neutral	0.99	neutral	0.80	9.48	deleterious	0.47	0.55	0.24	neutral	0.27	neutral	0.26	neutral	0.42	neutral	2	0.01	neutral	0.99	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	1.17	medium_impact	-2.99	low_impact	0.70	0.85	11.61	10.25	0.28	N	0.01	polymorphism	1	0.00	rs371771942	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13819	13819	T	G	MI.22419	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1483	495	F	V	Ttc/Gtc	-5.56	0	0.01	benign	0.01	neutral	0.66	neutral	1.06	neutral	0.69	neutral	1.86	neutral_impact	-0.52	0.85	neutral	0.97	neutral	1.07	11.04	neutral	0.29	0.45	0.3	neutral	0.35	neutral	0.27	neutral	0.45	neutral	1	0.33	neutral	0.83	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.39	medium_impact	-1.68	low_impact	0.70	0.85	11.61	10.25	0.25	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6075	6075	G	T	MI.2242	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	172	58	V	F	Gtc/Ttc	-4.5	0	0	possibly_damaging	0.8	deleterious	0.01	neutral	2.81	neutral	0	deleterious	-3.06	medium_impact	2.75	0.58	damaging	0.47	neutral	3.48	23.10	deleterious	0.11	0.55	0.25	neutral	0.95	disease	0.62	disease	0.8	disease	6	0.99	deleterious	0.11	neutral	4	deleterious	0.74	deleterious	-1.32	low_impact	-0.92	medium_impact	1.44	medium_impact	0.58	0.9	1.75	6.95	0.32	N	0.86	polymorphism	0.73	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13820	13820	T	A	MI.22420	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1484	495	F	Y	tTc/tAc	-3.73	0	0	benign	0.26	neutral	1	neutral	0.93	neutral	-1.68	neutral	-0.83	low_impact	0.8	0.82	neutral	0.63	neutral	2.54	19.72	deleterious	0.34	0.5	0.58	disease	0.37	neutral	0.47	neutral	0.62	disease	2	0.26	neutral	0.87	deleterious	-6	neutral	0.41	neutral	-0.32	medium_impact	1.89	high_impact	-0.47	medium_impact	0.67	0.85	11.61	10.25	0.21	N	0.04	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13820	13820	T	C	MI.22421	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1484	495	F	S	tTc/tCc	-3.73	0	0	benign	0.01	neutral	0.56	neutral	0.96	neutral	-0.64	neutral	-1.38	neutral_impact	0.26	0.8	neutral	0.6	neutral	2.38	18.67	deleterious	0.21	0.45	0.51	disease	0.49	neutral	0.5	neutral	0.44	neutral	1	0.43	neutral	0.78	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.29	medium_impact	-0.97	medium_impact	0.64	0.8	11.61	10.25	0.22	N	0.01	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13820	13820	T	G	MI.22422	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1484	495	F	C	tTc/tGc	-3.73	0	0	possibly_damaging	0.49	neutral	0.17	neutral	0.91	neutral	-2.49	neutral	-0.82	low_impact	0.8	0.75	neutral	0.48	neutral	3.84	23.40	deleterious	0.21	0.45	0.77	disease	0.63	disease	0.49	neutral	0.52	disease	0	0.81	neutral	0.34	neutral	-3	neutral	0.63	deleterious	-0.73	medium_impact	-0.15	medium_impact	-0.47	medium_impact	0.51	0.8	11.61	10.25	0.32	N	0.07	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13821	13821	C	G	MI.22423	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1485	495	F	L	ttC/ttG	0.4	0	0	benign	0	neutral	0.98	neutral	1.17	neutral	1.48	neutral	1.89	neutral_impact	-1.96	0.86	neutral	0.99	neutral	1.12	11.32	neutral	0.47	0.55	0.24	neutral	0.27	neutral	0.26	neutral	0.42	neutral	2	0.01	neutral	0.99	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	1.17	medium_impact	-2.99	low_impact	0.70	0.85	11.61	10.25	0.28	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13821	13821	C	A	MI.22424	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1485	495	F	L	ttC/ttA	0.4	0	0	benign	0	neutral	0.98	neutral	1.17	neutral	1.48	neutral	1.89	neutral_impact	-1.96	0.86	neutral	0.99	neutral	1.45	13.05	neutral	0.47	0.55	0.24	neutral	0.27	neutral	0.26	neutral	0.42	neutral	2	0.01	neutral	0.99	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	1.17	medium_impact	-2.99	low_impact	0.70	0.85	11.61	10.25	0.28	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13822	13822	C	A	MI.22425	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1486	496	L	M	Cta/Ata	-5.79	0	0	possibly_damaging	0.76	neutral	0.32	neutral	0.63	neutral	-2.71	neutral	-1.06	medium_impact	1.95	0.86	neutral	0.98	neutral	2.55	19.81	deleterious	0.33	0.5	0.66	disease	0.36	neutral	0.36	neutral	0.63	disease	3	0.8	neutral	0.28	neutral	0	NA	0.72	deleterious	-1.22	low_impact	0.05	medium_impact	0.58	medium_impact	0.83	0.85	7.13	9.14	0.43	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13822	13822	C	G	MI.22426	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1486	496	L	V	Cta/Gta	-5.79	0	0	possibly_damaging	0.9	neutral	0.59	neutral	0.77	neutral	-1.17	neutral	-1.68	medium_impact	2.04	0.79	neutral	0.81	neutral	2.36	18.56	deleterious	0.36	0.5	0.39	neutral	0.35	neutral	0.38	neutral	0.46	neutral	1	0.88	neutral	0.35	neutral	0	NA	0.69	deleterious	-1.65	low_impact	0.32	medium_impact	0.66	medium_impact	0.69	0.85	7.13	9.14	0.27	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13823	13823	T	C	MI.22427	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1487	496	L	P	cTa/cCa	-10.37	0	0	probably_damaging	1	neutral	0.2	neutral	0.57	deleterious	-5.07	deleterious	-4.94	medium_impact	3.37	0.57	damaging	0.31	neutral	4.01	23.60	deleterious	0.12	0.4	0.87	disease	0.87	disease	0.71	disease	0.82	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	-0.1	medium_impact	1.88	medium_impact	0.62	0.8	7.13	9.14	0.29	N	0.98	polymorphism	0.99	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13823	13823	T	G	MI.22428	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1487	496	L	R	cTa/cGa	-10.37	0	0	probably_damaging	0.98	neutral	0.33	neutral	0.57	deleterious	-4.49	deleterious	-4.25	medium_impact	3.37	0.66	neutral	0.38	neutral	4.27	24.00	deleterious	0.1	0.4	0.75	disease	0.87	disease	0.71	disease	0.79	disease	6	0.99	deleterious	0.18	neutral	1	deleterious	0.88	deleterious	-2.35	low_impact	0.06	medium_impact	1.88	medium_impact	0.66	0.8	7.13	9.14	0.29	N	0.97	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13823	13823	T	A	MI.22429	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1487	496	L	Q	cTa/cAa	-10.37	0	0	probably_damaging	0.99	neutral	0.27	neutral	0.57	deleterious	-4.65	deleterious	-4.16	medium_impact	3.37	0.74	neutral	0.51	neutral	4.18	23.80	deleterious	0.14	0.4	0.82	disease	0.78	disease	0.59	disease	0.75	disease	5	0.99	deleterious	0.14	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	-0.01	medium_impact	1.88	medium_impact	0.68	0.85	7.13	9.14	0.32	N	0.94	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6076	6076	T	C	MI.2243	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	173	58	V	A	gTc/gCc	7.3	1	0	possibly_damaging	0.56	deleterious	0	neutral	2.68	neutral	-1.61	deleterious	-2.54	high_impact	4.38	0.65	neutral	0.59	neutral	3.08	22.50	deleterious	0.19	0.55	0.67	disease	0.73	disease	0.61	disease	0.66	disease	3	1	deleterious	0.22	neutral	5	deleterious	0.62	deleterious	-0.86	medium_impact	-1.48	low_impact	2.95	high_impact	0.47	0.9	1.75	6.95	0.57	P	0.47	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13825	13825	G	C	MI.22430	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1489	497	G	R	Gga/Cga	-1.67	0	0	probably_damaging	1	neutral	0.35	neutral	-0.48	deleterious	-7.49	deleterious	-7.18	high_impact	3.86	0.57	damaging	0.22	damaging	4.00	23.60	deleterious	0.13	0.4	0.75	disease	0.92	disease	0.82	disease	0.86	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	0.08	medium_impact	2.32	high_impact	0.76	0.85	28.86	7.18	0.37	N	1.00	polymorphism	0.96	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13825	13825	G	T	MI.22431	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1489	497	G	W	Gga/Tga	-1.67	0	0	probably_damaging	1	neutral	0.22	neutral	-0.49	deleterious	-10.48	deleterious	-7.18	high_impact	3.86	0.61	neutral	0.21	damaging	4.51	24.30	deleterious	0.16	0.45	0.95	disease	0.92	disease	0.78	disease	0.89	disease	8	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.6	low_impact	-0.07	medium_impact	2.32	high_impact	0.44	0.8	28.86	7.18	0.35	N	1.00	polymorphism	0.93	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13826	13826	G	A	MI.22432	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1490	497	G	E	gGa/gAa	5.9	1	0	probably_damaging	1	neutral	0.32	neutral	-0.48	deleterious	-7	deleterious	-7.18	high_impact	3.86	0.62	neutral	0.24	damaging	4.02	23.60	deleterious	0.17	0.45	0.66	disease	0.89	disease	0.82	disease	0.85	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.05	medium_impact	2.32	high_impact	0.65	0.8	28.86	7.18	0.55	P	1.00	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13826	13826	G	T	MI.22433	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1490	497	G	V	gGa/gTa	5.9	1	0	probably_damaging	1	neutral	0.52	neutral	-0.47	deleterious	-6.72	deleterious	-8.08	high_impact	3.86	0.59	damaging	0.27	damaging	3.87	23.50	deleterious	0.17	0.45	0.65	disease	0.86	disease	0.75	disease	0.8	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	0.25	medium_impact	2.32	high_impact	0.62	0.8	28.86	7.18	0.53	P	0.98	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13826	13826	G	C	MI.22434	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1490	497	G	A	gGa/gCa	5.9	1	0	probably_damaging	1	neutral	0.52	neutral	-0.4	deleterious	-4.79	deleterious	-5.39	medium_impact	2.5	0.55	damaging	0.57	neutral	3.18	22.70	deleterious	0.36	0.5	0.56	disease	0.66	disease	0.66	disease	0.52	disease	0	1	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.25	medium_impact	1.08	medium_impact	0.83	0.9	28.86	7.18	0.47	N	0.79	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13828	13828	C	A	MI.22435	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1492	498	L	I	Ctt/Att	-20	0	0	possibly_damaging	0.64	neutral	0.45	neutral	0.81	neutral	-1	neutral	-0.34	low_impact	1.62	0.8	neutral	0.82	neutral	2.71	20.90	deleterious	0.38	0.5	0.28	neutral	0.28	neutral	0.29	neutral	0.45	neutral	1	0.64	neutral	0.41	neutral	-3	neutral	0.49	deleterious	-0.98	medium_impact	0.18	medium_impact	0.28	medium_impact	0.75	0.85	16.92	14.54	0.38	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13828	13828	C	G	MI.22436	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1492	498	L	V	Ctt/Gtt	-20	0	0	possibly_damaging	0.53	neutral	0.53	neutral	0.75	neutral	-1.46	neutral	-1.24	medium_impact	2.15	0.74	neutral	0.81	neutral	3.11	22.50	deleterious	0.4	0.5	0.35	neutral	0.41	neutral	0.33	neutral	0.46	neutral	1	0.5	neutral	0.5	deleterious	0	NA	0.53	deleterious	-0.8	medium_impact	0.26	medium_impact	0.76	medium_impact	0.78	0.85	16.92	14.54	0.36	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13828	13828	C	T	MI.22437	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1492	498	L	F	Ctt/Ttt	-20	0	0	benign	0.05	neutral	0.78	neutral	0.67	neutral	-2.58	neutral	3.69	neutral_impact	0.49	0.89	neutral	0.95	neutral	-0.18	1.20	neutral	0.43	0.55	0.34	neutral	0.29	neutral	0.31	neutral	0.46	neutral	1	0.14	neutral	0.87	deleterious	-6	neutral	0.17	neutral	0.47	medium_impact	0.54	medium_impact	-0.76	medium_impact	0.70	0.85	16.92	14.54	0.3	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13829	13829	T	C	MI.22438	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1493	498	L	P	cTt/cCt	-0.75	0	0	probably_damaging	0.96	neutral	0.24	neutral	0.61	deleterious	-4.79	deleterious	-4.1	medium_impact	3.3	0.53	damaging	0.39	neutral	4.05	23.70	deleterious	0.13	0.4	0.54	disease	0.87	disease	0.69	disease	0.77	disease	5	0.97	neutral	0.14	neutral	1	deleterious	0.83	deleterious	-2.06	low_impact	-0.04	medium_impact	1.81	medium_impact	0.67	0.85	16.92	14.54	0.34	N	0.98	polymorphism	1	0.21	.	.	.	.	.	.	COSM6716779	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13829	13829	T	G	MI.22439	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1493	498	L	R	cTt/cGt	-0.75	0	0	probably_damaging	0.95	neutral	0.36	neutral	0.62	deleterious	-4.17	deleterious	-3.2	medium_impact	3.3	0.58	damaging	0.45	neutral	4.33	24.00	deleterious	0.09	0.4	0.77	disease	0.89	disease	0.69	disease	0.77	disease	5	0.95	neutral	0.21	neutral	1	deleterious	0.86	deleterious	-1.96	low_impact	0.1	medium_impact	1.81	medium_impact	0.72	0.85	16.92	14.54	0.3	N	0.95	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6076	6076	T	A	MI.2244	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	173	58	V	D	gTc/gAc	7.3	1	0	probably_damaging	0.91	deleterious	0	neutral	2.62	deleterious	-4.35	deleterious	-4.39	high_impact	4.92	0.63	neutral	0.49	neutral	4.29	24.00	deleterious	0.07	0.55	0.92	disease	0.92	disease	0.73	disease	0.84	disease	7	1	deleterious	0.05	neutral	6	deleterious	0.85	deleterious	-1.7	low_impact	-1.48	low_impact	3.44	high_impact	0.63	0.9	1.75	6.95	0.7	P	0.83	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13829	13829	T	A	MI.22440	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1493	498	L	H	cTt/cAt	-0.75	0	0	probably_damaging	0.98	neutral	0.53	neutral	0.61	deleterious	-4.74	neutral	-1.92	medium_impact	3.3	0.69	neutral	0.49	neutral	4.38	24.10	deleterious	0.14	0.4	0.82	disease	0.78	disease	0.65	disease	0.75	disease	5	0.97	neutral	0.28	neutral	1	deleterious	0.81	deleterious	-2.35	low_impact	0.26	medium_impact	1.81	medium_impact	0.62	0.8	16.92	14.54	0.27	N	0.82	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13831	13831	C	A	MI.22441	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1495	499	L	M	Cta/Ata	-9.69	0	0	probably_damaging	0.97	neutral	0.31	neutral	0.72	neutral	-2.4	neutral	0.11	low_impact	1.73	0.85	neutral	0.98	neutral	2.52	19.58	deleterious	0.35	0.5	0.57	disease	0.33	neutral	0.29	neutral	0.61	disease	2	0.97	neutral	0.17	neutral	-2	neutral	0.69	deleterious	-2.18	low_impact	0.04	medium_impact	0.38	medium_impact	0.78	0.85	22.55	19.69	0.52	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	C13831A	Thyroid Cancer Cell Line	-	+	Reported	1	.	P	P	neutral
chrM	13831	13831	C	G	MI.22442	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1495	499	L	V	Cta/Gta	-9.69	0	0	possibly_damaging	0.61	neutral	0.68	neutral	0.82	neutral	-1.16	neutral	0.09	medium_impact	2.21	0.83	neutral	0.97	neutral	2.42	18.92	deleterious	0.31	0.45	0.47	neutral	0.36	neutral	0.33	neutral	0.46	neutral	1	0.53	neutral	0.54	deleterious	0	NA	0.69	deleterious	-0.93	medium_impact	0.41	medium_impact	0.82	medium_impact	0.77	0.85	22.55	19.69	0.35	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13832	13832	T	C	MI.22443	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1496	499	L	P	cTa/cCa	-3.27	0	0	probably_damaging	0.99	neutral	0.28	neutral	0.67	deleterious	-4.54	deleterious	-2.57	medium_impact	3.25	0.57	damaging	0.37	neutral	3.96	23.60	deleterious	0.11	0.4	0.84	disease	0.87	disease	0.69	disease	0.8	disease	6	0.99	deleterious	0.15	neutral	1	deleterious	0.87	deleterious	-2.64	low_impact	0.01	medium_impact	1.77	medium_impact	0.63	0.8	22.55	19.69	0.26	N	0.89	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13832	13832	T	A	MI.22444	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1496	499	L	Q	cTa/cAa	-3.27	0	0	probably_damaging	0.99	neutral	0.3	neutral	0.67	deleterious	-4.13	neutral	-2.05	medium_impact	3.25	0.73	neutral	0.55	neutral	4.08	23.70	deleterious	0.13	0.4	0.74	disease	0.74	disease	0.55	disease	0.71	disease	4	0.99	deleterious	0.16	neutral	1	deleterious	0.79	deleterious	-2.64	low_impact	0.03	medium_impact	1.77	medium_impact	0.66	0.8	22.55	19.69	0.31	N	0.72	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13832	13832	T	G	MI.22445	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1496	499	L	R	cTa/cGa	-3.27	0	0	probably_damaging	0.98	neutral	0.34	neutral	0.68	deleterious	-3.96	neutral	-2.31	medium_impact	3.25	0.65	neutral	0.43	neutral	4.19	23.90	deleterious	0.09	0.35	0.79	disease	0.87	disease	0.67	disease	0.78	disease	6	0.99	deleterious	0.18	neutral	1	deleterious	0.86	deleterious	-2.35	low_impact	0.07	medium_impact	1.77	medium_impact	0.70	0.85	22.55	19.69	0.29	N	0.69	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13834	13834	A	G	MI.22446	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1498	500	T	A	Aca/Gca	-8.08	0	0	benign	0	neutral	0.58	neutral	0.99	neutral	-0.08	neutral	-0.32	low_impact	1.52	0.85	neutral	0.81	neutral	0.40	6.59	deleterious	0.52	0.6	0.49	neutral	0.31	neutral	0.45	neutral	0.42	neutral	2	0.41	neutral	0.79	deleterious	-6	neutral	0.17	neutral	2.1	high_impact	0.31	medium_impact	0.19	medium_impact	0.50	0.8	23.88	19.35	0.29	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13834	13834	A	C	MI.22447	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1498	500	T	P	Aca/Cca	-8.08	0	0	benign	0.4	neutral	0.26	neutral	0.91	neutral	-2.74	neutral	-1.96	low_impact	1.86	0.71	neutral	0.41	neutral	3.43	23.00	deleterious	0.17	0.45	0.7	disease	0.82	disease	0.68	disease	0.79	disease	6	0.7	neutral	0.43	neutral	-6	neutral	0.78	deleterious	-0.58	medium_impact	-0.02	medium_impact	0.5	medium_impact	0.68	0.85	23.88	19.35	0.27	N	0.43	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13834	13834	A	T	MI.22448	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1498	500	T	S	Aca/Tca	-8.08	0	0	benign	0.18	neutral	0.47	neutral	0.97	neutral	-0.57	neutral	-1.07	neutral_impact	0.72	0.88	neutral	0.77	neutral	1.66	14.20	neutral	0.53	0.6	0.48	neutral	0.37	neutral	0.43	neutral	0.44	neutral	1	0.44	neutral	0.65	deleterious	-6	neutral	0.42	neutral	-0.12	medium_impact	0.2	medium_impact	-0.55	medium_impact	0.75	0.85	23.88	19.35	0.34	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13835	13835	C	T	MI.22449	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1499	500	T	M	aCa/aTa	-5.79	0	0	benign	0.02	neutral	0.35	neutral	1.05	neutral	0.59	neutral	1.99	neutral_impact	-0.18	0.88	neutral	0.9	neutral	2.40	18.80	deleterious	0.3	0.45	0.61	disease	0.34	neutral	0.32	neutral	0.6	disease	2	0.64	neutral	0.67	deleterious	-6	neutral	0.66	deleterious	0.86	medium_impact	0.08	medium_impact	-1.37	low_impact	0.77	0.85	23.88	19.35	0.3	N	0.21	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6076	6076	T	G	MI.2245	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	173	58	V	G	gTc/gGc	7.3	1	0	probably_damaging	0.9	deleterious	0	neutral	2.63	deleterious	-3.34	deleterious	-4.45	high_impact	4.92	0.54	damaging	0.62	neutral	3.61	23.20	deleterious	0.09	0.55	0.87	disease	0.88	disease	0.61	disease	0.78	disease	6	1	deleterious	0.05	neutral	6	deleterious	0.83	deleterious	-1.65	low_impact	-1.48	low_impact	3.44	high_impact	0.58	0.9	1.75	6.95	0.67	P	0.71	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13835	13835	C	A	MI.22450	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1499	500	T	K	aCa/aAa	-5.79	0	0	benign	0.23	neutral	0.32	neutral	0.92	neutral	-2.12	neutral	-1.45	low_impact	1.86	0.77	neutral	0.48	neutral	4.23	23.90	deleterious	0.19	0.45	0.72	disease	0.72	disease	0.68	disease	0.74	disease	5	0.61	neutral	0.55	deleterious	-6	neutral	0.65	deleterious	-0.25	medium_impact	0.05	medium_impact	0.5	medium_impact	0.72	0.85	23.88	19.35	0.24	N	0.45	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13837	13837	G	C	MI.22451	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1501	501	A	P	Gcc/Ccc	-9.23	0	0	probably_damaging	0.99	neutral	0.22	neutral	0.7	deleterious	-4.12	deleterious	-4.49	high_impact	3.75	0.6	damaging	0.35	neutral	3.93	23.50	deleterious	0.09	0.35	0.72	disease	0.92	disease	0.76	disease	0.84	disease	7	0.99	deleterious	0.12	neutral	2	deleterious	0.88	deleterious	-2.64	low_impact	-0.07	medium_impact	2.22	high_impact	0.81	0.85	3.98	8.04	0.37	N	0.93	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13837	13837	G	T	MI.22452	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1501	501	A	S	Gcc/Tcc	-9.23	0	0	possibly_damaging	0.9	neutral	0.62	neutral	0.82	neutral	-1.27	deleterious	-2.69	medium_impact	2.19	0.64	neutral	0.67	neutral	3.76	23.40	deleterious	0.38	0.5	0.56	disease	0.78	disease	0.55	disease	0.54	disease	1	0.88	neutral	0.36	neutral	0	NA	0.80	deleterious	-1.65	low_impact	0.35	medium_impact	0.8	medium_impact	0.89	0.9	3.98	8.04	0.26	N	0.51	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13837	13837	G	A	MI.22453	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1501	501	A	T	Gcc/Acc	-9.23	0	0	benign	0.42	neutral	0.53	neutral	0.76	neutral	-2.22	deleterious	-3.59	medium_impact	2.48	0.59	damaging	0.64	neutral	4.30	24.00	deleterious	0.45	0.55	0.66	disease	0.81	disease	0.58	disease	0.58	disease	2	0.43	neutral	0.56	deleterious	-3	neutral	0.81	deleterious	-0.61	medium_impact	0.26	medium_impact	1.06	medium_impact	0.80	0.85	3.98	8.04	0.28	N	0.83	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13838	13838	C	A	MI.22454	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1502	501	A	D	gCc/gAc	3.38	0.99	0	probably_damaging	0.98	neutral	0.21	neutral	0.71	deleterious	-3.43	deleterious	-5.39	high_impact	3.75	0.62	neutral	0.39	neutral	4.73	24.60	deleterious	0.12	0.4	0.81	disease	0.94	disease	0.75	disease	0.88	disease	8	0.99	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	-0.09	medium_impact	2.22	high_impact	0.76	0.85	3.98	8.04	0.47	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13838	13838	C	G	MI.22455	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1502	501	A	G	gCc/gGc	3.38	0.99	0	probably_damaging	0.94	neutral	0.41	neutral	1.03	neutral	0.16	deleterious	-3.59	medium_impact	2.37	0.64	neutral	0.68	neutral	4.05	23.70	deleterious	0.23	0.45	0.52	disease	0.8	disease	0.54	disease	0.53	disease	1	0.94	neutral	0.24	neutral	1	deleterious	0.77	deleterious	-1.88	low_impact	0.15	medium_impact	0.96	medium_impact	0.80	0.85	3.98	8.04	0.39	N	0.47	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13838	13838	C	T	MI.22456	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1502	501	A	V	gCc/gTc	3.38	0.99	0	possibly_damaging	0.9	neutral	0.59	neutral	0.75	neutral	-2.39	deleterious	-3.59	high_impact	3.75	0.6	damaging	0.46	neutral	4.55	24.30	deleterious	0.37	0.5	0.68	disease	0.85	disease	0.63	disease	0.73	disease	5	0.88	neutral	0.35	neutral	1	deleterious	0.82	deleterious	-1.65	low_impact	0.32	medium_impact	2.22	high_impact	0.87	0.9	3.98	8.04	0.49	N	0.89	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13840	13840	C	A	MI.22457	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1504	502	L	M	Cta/Ata	-7.85	0	0	benign	0.22	neutral	0.26	neutral	0.7	neutral	-1.95	neutral	0.95	neutral_impact	0.57	0.86	neutral	0.98	neutral	1.47	13.14	neutral	0.33	0.5	0.66	disease	0.18	neutral	0.28	neutral	0.36	neutral	3	0.69	neutral	0.52	deleterious	-6	neutral	0.70	deleterious	-0.22	medium_impact	-0.02	medium_impact	-0.68	medium_impact	0.76	0.85	18.24	13.14	0.43	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13840	13840	C	G	MI.22458	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1504	502	L	V	Cta/Gta	-7.85	0	0	possibly_damaging	0.53	neutral	0.52	neutral	0.73	neutral	-1.59	neutral	-1.18	medium_impact	2.89	0.74	neutral	0.65	neutral	3.13	22.60	deleterious	0.34	0.5	0.48	neutral	0.46	neutral	0.48	neutral	0.48	neutral	0	0.51	neutral	0.5	deleterious	0	NA	0.59	deleterious	-0.8	medium_impact	0.25	medium_impact	1.44	medium_impact	0.66	0.8	18.24	13.14	0.33	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13841	13841	T	G	MI.22459	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1505	502	L	R	cTa/cGa	-1.21	0	0	probably_damaging	0.93	neutral	0.35	neutral	0.61	deleterious	-4.33	deleterious	-3.44	medium_impact	3.23	0.66	neutral	0.34	neutral	4.22	23.90	deleterious	0.13	0.4	0.78	disease	0.88	disease	0.69	disease	0.78	disease	6	0.94	neutral	0.21	neutral	1	deleterious	0.88	deleterious	-1.81	low_impact	0.08	medium_impact	1.75	medium_impact	0.71	0.85	18.24	13.14	0.27	N	0.98	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6078	6078	A	C	MI.2246	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	175	59	T	P	Aca/Cca	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	2.27	deleterious	-6.46	deleterious	-3.83	high_impact	5.17	0.62	neutral	0.11	damaging	1.40	12.80	neutral	0.13	0.55	0.87	disease	0.79	disease	0.81	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.59	0.9	2.14	7.34	0.68	P	0.92	polymorphism	0.95	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13841	13841	T	A	MI.22460	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1505	502	L	Q	cTa/cAa	-1.21	0	0	probably_damaging	0.95	neutral	0.3	neutral	0.6	deleterious	-4.5	deleterious	-2.94	medium_impact	2.89	0.74	neutral	0.47	neutral	4.13	23.80	deleterious	0.16	0.45	0.84	disease	0.79	disease	0.56	disease	0.73	disease	5	0.96	neutral	0.18	neutral	1	deleterious	0.84	deleterious	-1.96	low_impact	0.03	medium_impact	1.44	medium_impact	0.66	0.8	18.24	13.14	0.29	N	0.92	polymorphism	0.99	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13841	13841	T	C	MI.22461	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1505	502	L	P	cTa/cCa	-1.21	0	0	probably_damaging	0.95	neutral	0.26	neutral	0.6	deleterious	-4.9	deleterious	-4.23	medium_impact	3.23	0.56	damaging	0.3	neutral	3.97	23.60	deleterious	0.14	0.4	0.8	disease	0.87	disease	0.7	disease	0.8	disease	6	0.96	neutral	0.16	neutral	1	deleterious	0.89	deleterious	-1.96	low_impact	-0.02	medium_impact	1.75	medium_impact	0.61	0.8	18.24	13.14	0.26	N	0.95	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13843	13843	G	A	MI.22462	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1507	503	D	N	Gac/Aac	0.17	0.2	0	probably_damaging	0.94	neutral	0.33	neutral	1.01	neutral	0.19	neutral	-2	medium_impact	2.13	0.74	neutral	0.38	neutral	4.30	24.00	deleterious	0.65	0.7	0.43	neutral	0.7	disease	0.67	disease	0.6	disease	2	0.94	neutral	0.2	neutral	1	deleterious	0.72	deleterious	-1.88	low_impact	0.06	medium_impact	0.74	medium_impact	0.83	0.85	15.92	17.99	0.28	N	0.47	polymorphism	0.57	0.04	.	.	.	.	.	.	COSM1155543	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13843	13843	G	C	MI.22463	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1507	503	D	H	Gac/Cac	0.17	0.2	0	probably_damaging	0.98	neutral	0.54	neutral	0.96	neutral	-1.36	neutral	-2.15	medium_impact	2.13	0.77	neutral	0.35	neutral	3.71	23.30	deleterious	0.4	0.5	0.64	disease	0.7	disease	0.75	disease	0.78	disease	6	0.98	deleterious	0.28	neutral	1	deleterious	0.74	deleterious	-2.35	low_impact	0.27	medium_impact	0.74	medium_impact	0.43	0.8	15.92	17.99	0.22	N	0.66	disease_causing	0.8	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13843	13843	G	T	MI.22464	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1507	503	D	Y	Gac/Tac	0.17	0.2	0	probably_damaging	0.99	neutral	1	neutral	0.97	neutral	-0.82	deleterious	-3.94	medium_impact	2.34	0.76	neutral	0.31	neutral	4.00	23.60	deleterious	0.35	0.5	0.46	neutral	0.82	disease	0.74	disease	0.79	disease	6	0.99	deleterious	0.51	deleterious	1	deleterious	0.75	deleterious	-2.64	low_impact	1.89	high_impact	0.94	medium_impact	0.52	0.8	15.92	17.99	0.24	N	0.92	disease_causing	0.89	0.08	rs28562381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13844	13844	A	T	MI.22465	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1508	503	D	V	gAc/gTc	4.06	1	0	probably_damaging	0.98	neutral	0.51	neutral	1.02	neutral	0.46	deleterious	-3.91	medium_impact	2.34	0.78	neutral	0.34	neutral	3.81	23.40	deleterious	0.32	0.5	0.34	neutral	0.74	disease	0.7	disease	0.72	disease	4	0.98	neutral	0.27	neutral	1	deleterious	0.70	deleterious	-2.35	low_impact	0.24	medium_impact	0.94	medium_impact	0.46	0.8	15.92	17.99	0.39	N	0.88	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13844	13844	A	C	MI.22466	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1508	503	D	A	gAc/gCc	4.06	1	0	possibly_damaging	0.86	neutral	0.54	neutral	1.01	neutral	0.28	deleterious	-3.01	low_impact	1.88	0.76	neutral	0.56	neutral	3.71	23.30	deleterious	0.33	0.5	0.35	neutral	0.6	disease	0.69	disease	0.52	disease	0	0.84	neutral	0.34	neutral	-3	neutral	0.70	deleterious	-1.5	low_impact	0.27	medium_impact	0.51	medium_impact	0.48	0.8	15.92	17.99	0.42	N	0.72	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13844	13844	A	G	MI.22467	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1508	503	D	G	gAc/gGc	4.06	1	0	possibly_damaging	0.89	neutral	0.37	neutral	0.97	neutral	-1.04	deleterious	-3.76	medium_impact	2.34	0.89	neutral	0.4	neutral	4.02	23.60	deleterious	0.35	0.5	0.3	neutral	0.75	disease	0.71	disease	0.75	disease	5	0.9	neutral	0.24	neutral	0	NA	0.67	deleterious	-1.61	low_impact	0.11	medium_impact	0.94	medium_impact	0.39	0.8	15.92	17.99	0.53	N	0.80	disease_causing	0.99	0.07	.	.	.	.	.	.	COSM488753	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13845	13845	C	G	MI.22468	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1509	503	D	E	gaC/gaG	5.44	1	0	benign	0.12	neutral	0.33	neutral	1.22	neutral	2.2	neutral	2.17	neutral_impact	-0.72	0.79	neutral	0.97	neutral	1.29	12.24	neutral	0.57	0.65	0.26	neutral	0.14	neutral	0.4	neutral	0.22	neutral	6	0.62	neutral	0.61	deleterious	-6	neutral	0.65	deleterious	0.08	medium_impact	0.06	medium_impact	-1.86	low_impact	0.71	0.85	15.92	17.99	0.57	P	0.08	disease_causing	0.82	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13845	13845	C	A	MI.22469	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1509	503	D	E	gaC/gaA	5.44	1	0	benign	0.12	neutral	0.33	neutral	1.22	neutral	2.2	neutral	2.17	neutral_impact	-0.72	0.79	neutral	0.97	neutral	1.63	14.01	neutral	0.57	0.65	0.26	neutral	0.14	neutral	0.4	neutral	0.22	neutral	6	0.62	neutral	0.61	deleterious	-6	neutral	0.65	deleterious	0.08	medium_impact	0.06	medium_impact	-1.86	low_impact	0.71	0.85	15.92	17.99	0.57	P	0.08	disease_causing	0.82	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6078	6078	A	T	MI.2247	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	175	59	T	S	Aca/Tca	-6.81	0	0	probably_damaging	0.98	deleterious	0	neutral	2.25	deleterious	-3.75	deleterious	-2.55	high_impact	3.86	0.64	neutral	0.16	damaging	1.33	12.41	neutral	0.3	0.55	0.61	disease	0.71	disease	0.64	disease	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-1.48	low_impact	2.47	high_impact	0.66	0.9	2.14	7.34	0.32	N	0.79	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13846	13846	C	A	MI.22470	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1510	504	L	I	Ctc/Atc	1.31	0.95	0	probably_damaging	1	neutral	0.56	neutral	0.71	neutral	-1.3	neutral	-1.51	medium_impact	2.02	0.81	neutral	0.96	neutral	3.19	22.70	deleterious	0.37	0.5	0.44	neutral	0.4	neutral	0.28	neutral	0.45	neutral	1	1	deleterious	0.28	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.29	medium_impact	0.64	medium_impact	0.72	0.85	11.28	15.85	0.34	N	0.16	polymorphism	0.8	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13846	13846	C	G	MI.22471	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1510	504	L	V	Ctc/Gtc	1.31	0.95	0	probably_damaging	1	neutral	0.55	neutral	0.6	neutral	-2.29	neutral	-2.39	medium_impact	2.73	0.8	neutral	0.74	neutral	3.52	23.10	deleterious	0.4	0.5	0.44	neutral	0.54	disease	0.49	neutral	0.48	neutral	0	1	deleterious	0.28	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.28	medium_impact	1.29	medium_impact	0.80	0.85	11.28	15.85	0.33	N	0.55	polymorphism	0.69	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13846	13846	C	T	MI.22472	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1510	504	L	F	Ctc/Ttc	1.31	0.95	0	probably_damaging	1	neutral	0.78	neutral	0.6	neutral	-2.32	deleterious	-3.42	medium_impact	2.89	0.73	neutral	0.27	damaging	4.04	23.70	deleterious	0.37	0.5	0.69	disease	0.66	disease	0.53	disease	0.54	disease	1	1	deleterious	0.39	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.54	medium_impact	1.44	medium_impact	0.68	0.85	11.28	15.85	0.28	N	0.84	disease_causing	0.69	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13847	13847	T	G	MI.22473	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1511	504	L	R	cTc/cGc	-0.06	0.87	0.01	probably_damaging	1	neutral	0.36	neutral	0.5	deleterious	-4.67	deleterious	-5.27	high_impact	3.69	0.61	neutral	0.17	damaging	4.31	24.00	deleterious	0.12	0.4	0.82	disease	0.91	disease	0.74	disease	0.83	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	0.1	medium_impact	2.17	high_impact	0.68	0.85	11.28	15.85	0.35	N	0.98	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13847	13847	T	C	MI.22474	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1511	504	L	P	cTc/cCc	-0.06	0.87	0.01	probably_damaging	1	neutral	0.28	neutral	0.49	deleterious	-5.26	deleterious	-6.09	high_impact	3.69	0.56	damaging	0.12	damaging	4.02	23.60	deleterious	0.12	0.4	0.72	disease	0.87	disease	0.74	disease	0.81	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.6	low_impact	0.01	medium_impact	2.17	high_impact	0.57	0.8	11.28	15.85	0.34	N	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13847	13847	T	A	MI.22475	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1511	504	L	H	cTc/cAc	-0.06	0.87	0.01	probably_damaging	1	neutral	0.54	neutral	0.49	deleterious	-5.22	deleterious	-6.09	high_impact	3.69	0.66	neutral	0.18	damaging	4.24	23.90	deleterious	0.16	0.45	0.79	disease	0.83	disease	0.71	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.27	medium_impact	2.17	high_impact	0.62	0.8	11.28	15.85	0.3	N	0.87	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13849	13849	A	C	MI.22476	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1513	505	N	H	Aac/Cac	-13.12	0	0	benign	0.02	neutral	0.53	neutral	0.91	neutral	-2.33	deleterious	-3.41	medium_impact	2.28	0.79	neutral	0.74	neutral	0.04	2.98	deleterious	0.54	0.6	0.78	disease	0.39	neutral	0.51	disease	0.66	disease	3	0.45	neutral	0.76	deleterious	-3	neutral	0.23	neutral	0.86	medium_impact	0.26	medium_impact	0.88	medium_impact	0.39	0.8	20.23	16.88	0.32	N	0.50	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	A13849C	MELAS	+	-	Reported - possible secondary	1	.	N	N	damaging
chrM	13849	13849	A	G	MI.22477	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1513	505	N	D	Aac/Gac	-13.12	0	0	benign	0.23	neutral	0.25	neutral	0.92	neutral	-1.81	deleterious	-3.25	medium_impact	2.28	0.77	neutral	0.66	neutral	1.28	12.18	neutral	0.7	0.75	0.71	disease	0.45	neutral	0.59	disease	0.67	disease	3	0.7	neutral	0.51	deleterious	-3	neutral	0.60	deleterious	-0.25	medium_impact	-0.03	medium_impact	0.88	medium_impact	0.45	0.8	20.23	16.88	0.35	N	0.64	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13849	13849	A	T	MI.22478	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1513	505	N	Y	Aac/Tac	-13.12	0	0	benign	0.01	neutral	1	neutral	0.93	neutral	-1.43	deleterious	-5.28	low_impact	1.04	0.82	neutral	0.63	neutral	0.46	7.13	deleterious	0.39	0.5	0.44	neutral	0.48	neutral	0.32	neutral	0.49	neutral	0	0.01	neutral	1	deleterious	-6	neutral	0.19	neutral	1.15	medium_impact	1.89	high_impact	-0.25	medium_impact	0.31	0.8	20.23	16.88	0.25	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13850	13850	A	T	MI.22479	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1514	505	N	I	aAc/aTc	0.86	0	0	benign	0	neutral	0.49	neutral	0.96	neutral	-0.59	deleterious	-5.63	low_impact	0.81	0.88	neutral	0.85	neutral	2.65	20.50	deleterious	0.35	0.5	0.62	disease	0.46	neutral	0.26	neutral	0.61	disease	2	0.5	neutral	0.75	deleterious	-6	neutral	0.64	deleterious	2.1	high_impact	0.22	medium_impact	-0.46	medium_impact	0.30	0.8	20.23	16.88	0.37	N	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6078	6078	A	G	MI.2248	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	175	59	T	A	Aca/Gca	-6.81	0	0	probably_damaging	0.98	deleterious	0	neutral	2.2	deleterious	-4.2	deleterious	-3.19	high_impact	5.17	0.81	neutral	0.14	damaging	1.55	13.56	neutral	0.28	0.55	0.35	neutral	0.64	disease	0.66	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.71	deleterious	-2.35	low_impact	-1.48	low_impact	3.68	high_impact	0.53	0.9	2.14	7.34	0.49	N	0.69	polymorphism	0.99	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13850	13850	A	C	MI.22480	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1514	505	N	T	aAc/aCc	0.86	0	0	benign	0.01	neutral	0.44	neutral	1	neutral	0.06	deleterious	-3.54	neutral_impact	0.29	0.87	neutral	0.9	neutral	1.59	13.81	neutral	0.58	0.65	0.57	disease	0.23	neutral	0.21	neutral	0.54	disease	1	0.55	neutral	0.72	deleterious	-6	neutral	0.56	deleterious	1.15	medium_impact	0.18	medium_impact	-0.94	medium_impact	0.45	0.8	20.23	16.88	0.37	N	0.14	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13850	13850	A	G	MI.22481	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1514	505	N	S	aAc/aGc	0.86	0	0	benign	0.01	neutral	0.51	neutral	1.15	neutral	1.33	deleterious	-2.62	neutral_impact	-0.3	0.88	neutral	0.99	neutral	-0.06	2.01	deleterious	0.7	0.75	0.31	neutral	0.15	neutral	0.24	neutral	0.29	neutral	4	0.48	neutral	0.75	deleterious	-6	neutral	0.45	deleterious	1.15	medium_impact	0.24	medium_impact	-1.48	low_impact	0.21	0.8	20.23	16.88	0.43	N	0.11	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13851	13851	C	A	MI.22482	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1515	505	N	K	aaC/aaA	-0.06	0	0	benign	0.18	neutral	0.34	neutral	0.95	neutral	-0.9	deleterious	-3.91	low_impact	1.73	0.76	neutral	0.63	neutral	1.88	15.44	deleterious	0.66	0.7	0.53	disease	0.54	disease	0.51	disease	0.51	disease	0	0.6	neutral	0.58	deleterious	-6	neutral	0.59	deleterious	-0.12	medium_impact	0.07	medium_impact	0.38	medium_impact	0.43	0.8	20.23	16.88	0.35	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13851	13851	C	G	MI.22483	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1515	505	N	K	aaC/aaG	-0.06	0	0	benign	0.18	neutral	0.34	neutral	0.95	neutral	-0.9	deleterious	-3.91	low_impact	1.73	0.76	neutral	0.63	neutral	1.44	12.98	neutral	0.66	0.7	0.53	disease	0.54	disease	0.51	disease	0.51	disease	0	0.6	neutral	0.58	deleterious	-6	neutral	0.59	deleterious	-0.12	medium_impact	0.07	medium_impact	0.38	medium_impact	0.43	0.8	20.23	16.88	0.35	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13852	13852	T	A	MI.22484	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1516	506	Y	N	Tac/Aac	-3.5	0	0	benign	0.26	neutral	0.35	neutral	1.13	neutral	2.24	neutral	2.34	neutral_impact	-0.48	0.82	neutral	0.99	neutral	1.99	16.16	deleterious	0.47	0.55	0.25	neutral	0.27	neutral	0.2	neutral	0.43	neutral	1	0.58	neutral	0.55	deleterious	-6	neutral	0.62	deleterious	-0.32	medium_impact	0.08	medium_impact	-1.64	low_impact	0.39	0.8	27.53	15.58	0.36	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13852	13852	T	C	MI.22485	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1516	506	Y	H	Tac/Cac	-3.5	0	0	possibly_damaging	0.84	neutral	0.54	neutral	1	neutral	-0.11	neutral	0.59	neutral_impact	0.24	0.83	neutral	0.92	neutral	1.84	15.20	deleterious	0.65	0.7	0.43	neutral	0.31	neutral	0.25	neutral	0.48	neutral	1	0.82	neutral	0.35	neutral	-3	neutral	0.65	deleterious	-1.43	low_impact	0.27	medium_impact	-0.98	medium_impact	0.35	0.8	27.53	15.58	0.26	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13852	13852	T	G	MI.22486	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1516	506	Y	D	Tac/Gac	-3.5	0	0	benign	0.33	neutral	0.21	neutral	1.03	neutral	0.96	neutral	0.4	low_impact	1.28	0.78	neutral	0.72	neutral	2.66	20.60	deleterious	0.39	0.5	0.42	neutral	0.63	disease	0.43	neutral	0.5	neutral	0	0.75	neutral	0.44	neutral	-6	neutral	0.69	deleterious	-0.45	medium_impact	-0.09	medium_impact	-0.03	medium_impact	0.51	0.8	27.53	15.58	0.32	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13853	13853	A	T	MI.22487	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1517	506	Y	F	tAc/tTc	-1.89	0	0	benign	0	neutral	0.72	neutral	0.98	neutral	-1.09	neutral	-0.38	neutral_impact	-0.3	0.84	neutral	0.87	neutral	0.25	5.20	deleterious	0.55	0.6	0.64	disease	0.28	neutral	0.32	neutral	0.56	disease	1	0.27	neutral	0.86	deleterious	-6	neutral	0.48	deleterious	2.1	high_impact	0.46	medium_impact	-1.48	low_impact	0.37	0.8	27.53	15.58	0.29	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13853	13853	A	C	MI.22488	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1517	506	Y	S	tAc/tCc	-1.89	0	0	benign	0.01	neutral	0.49	neutral	1.12	neutral	2.19	neutral	1.61	neutral_impact	-1.38	0.85	neutral	0.95	neutral	1.62	13.95	neutral	0.32	0.5	0.31	neutral	0.15	neutral	0.19	neutral	0.24	neutral	5	0.5	neutral	0.74	deleterious	-6	neutral	0.57	deleterious	1.15	medium_impact	0.22	medium_impact	-2.46	low_impact	0.33	0.8	27.53	15.58	0.4	N	0.20	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13853	13853	A	G	MI.22489	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1517	506	Y	C	tAc/tGc	-1.89	0	0	possibly_damaging	0.84	neutral	0.17	neutral	0.97	neutral	-2.16	neutral	-0.67	low_impact	0.94	0.73	neutral	0.48	neutral	2.86	21.70	deleterious	0.33	0.5	0.79	disease	0.59	disease	0.29	neutral	0.53	disease	1	0.92	neutral	0.17	neutral	-3	neutral	0.72	deleterious	-1.43	low_impact	-0.15	medium_impact	-0.34	medium_impact	0.13	0.8	27.53	15.58	0.38	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6079	6079	C	A	MI.2249	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	176	59	T	K	aCa/aAa	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.15	deleterious	-5.39	deleterious	-3.83	high_impact	5.17	0.66	neutral	0.09	damaging	4.27	23.90	deleterious	0.12	0.55	0.87	disease	0.88	disease	0.8	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.70	0.9	2.14	7.34	0.74	P	0.88	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13855	13855	C	G	MI.22490	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1519	507	L	V	Cta/Gta	-8.77	0	0	possibly_damaging	0.54	neutral	0.53	neutral	0.91	neutral	-0.6	neutral	-1.21	medium_impact	2.4	0.85	neutral	0.91	neutral	3.49	23.10	deleterious	0.57	0.65	0.46	neutral	0.34	neutral	0.57	disease	0.5	neutral	0	0.51	neutral	0.5	deleterious	0	NA	0.70	deleterious	-0.81	medium_impact	0.26	medium_impact	0.99	medium_impact	0.57	0.8	21.89	14.38	0.34	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13855	13855	C	A	MI.22491	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1519	507	L	M	Cta/Ata	-8.77	0	0	benign	0.15	neutral	0.25	neutral	0.89	neutral	-0.75	neutral	0.33	neutral_impact	0.48	0.87	neutral	0.99	neutral	2.21	17.55	deleterious	0.37	0.5	0.62	disease	0.12	neutral	0.23	neutral	0.39	neutral	2	0.71	neutral	0.55	deleterious	-6	neutral	0.69	deleterious	-0.03	medium_impact	-0.03	medium_impact	-0.76	medium_impact	0.68	0.85	21.89	14.38	0.5	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13856	13856	T	G	MI.22492	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1520	507	L	R	cTa/cGa	-2.58	0	0	probably_damaging	0.91	neutral	0.37	neutral	0.75	deleterious	-3.4	deleterious	-3.42	medium_impact	2.25	0.73	neutral	0.6	neutral	4.31	24.00	deleterious	0.28	0.45	0.71	disease	0.82	disease	0.72	disease	0.78	disease	6	0.91	neutral	0.23	neutral	1	deleterious	0.85	deleterious	-1.7	low_impact	0.11	medium_impact	0.85	medium_impact	0.60	0.8	21.89	14.38	0.25	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13856	13856	T	A	MI.22493	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1520	507	L	Q	cTa/cAa	-2.58	0	0	probably_damaging	0.93	neutral	0.32	neutral	0.75	deleterious	-3.49	deleterious	-3.01	low_impact	1.85	0.81	neutral	0.79	neutral	4.26	23.90	deleterious	0.25	0.45	0.79	disease	0.69	disease	0.36	neutral	0.6	disease	2	0.94	neutral	0.2	neutral	-2	neutral	0.81	deleterious	-1.81	low_impact	0.05	medium_impact	0.49	medium_impact	0.52	0.8	21.89	14.38	0.29	N	0.59	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13856	13856	T	C	MI.22494	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1520	507	L	P	cTa/cCa	-2.58	0	0	probably_damaging	0.93	neutral	0.23	neutral	0.74	deleterious	-4.12	deleterious	-4.15	medium_impact	2.15	0.64	neutral	0.57	neutral	4.06	23.70	deleterious	0.16	0.45	0.64	disease	0.83	disease	0.73	disease	0.79	disease	6	0.95	neutral	0.15	neutral	1	deleterious	0.85	deleterious	-1.81	low_impact	-0.06	medium_impact	0.76	medium_impact	0.40	0.8	21.89	14.38	0.27	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13858	13858	A	T	MI.22495	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1522	508	T	S	Acc/Tcc	-3.5	0	0	possibly_damaging	0.64	neutral	0.52	neutral	1.01	neutral	0.06	neutral	-1.71	low_impact	1.49	0.79	neutral	0.98	neutral	0.56	7.89	deleterious	0.57	0.65	0.42	neutral	0.4	neutral	0.31	neutral	0.45	neutral	1	0.61	neutral	0.44	neutral	-3	neutral	0.39	neutral	-0.98	medium_impact	0.25	medium_impact	0.16	medium_impact	0.41	0.8	5.64	13.54	0.34	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13858	13858	A	G	MI.22496	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1522	508	T	A	Acc/Gcc	-3.5	0	0	benign	0.05	neutral	0.58	neutral	0.91	neutral	-0.76	deleterious	-2.84	low_impact	1.9	0.84	neutral	0.98	neutral	0.59	8.12	deleterious	0.72	0.75	0.38	neutral	0.33	neutral	0.36	neutral	0.43	neutral	1	0.36	neutral	0.77	deleterious	-6	neutral	0.18	neutral	0.47	medium_impact	0.31	medium_impact	0.53	medium_impact	0.33	0.8	5.64	13.54	0.35	N	0.03	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13858	13858	A	C	MI.22497	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1522	508	T	P	Acc/Ccc	-3.5	0	0	probably_damaging	0.93	neutral	0.25	neutral	0.8	deleterious	-3.33	deleterious	-4.08	medium_impact	2.48	0.66	neutral	0.63	neutral	3.30	22.90	deleterious	0.21	0.45	0.77	disease	0.82	disease	0.74	disease	0.77	disease	5	0.95	neutral	0.16	neutral	1	deleterious	0.72	deleterious	-1.81	low_impact	-0.03	medium_impact	1.06	medium_impact	0.52	0.8	5.64	13.54	0.3	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13859	13859	C	A	MI.22498	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1523	508	T	N	aCc/aAc	-0.06	0	0	probably_damaging	0.93	neutral	0.38	neutral	0.88	neutral	-1.26	deleterious	-3.02	medium_impact	2.3	0.74	neutral	0.79	neutral	3.65	23.20	deleterious	0.56	0.6	0.6	disease	0.71	disease	0.49	neutral	0.55	disease	1	0.93	neutral	0.23	neutral	1	deleterious	0.66	deleterious	-1.81	low_impact	0.12	medium_impact	0.9	medium_impact	0.69	0.85	5.64	13.54	0.3	N	0.59	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13859	13859	C	G	MI.22499	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1523	508	T	S	aCc/aGc	-0.06	0	0	possibly_damaging	0.64	neutral	0.52	neutral	1.01	neutral	0.06	neutral	-1.71	low_impact	1.49	0.79	neutral	0.98	neutral	0.75	9.13	deleterious	0.57	0.65	0.42	neutral	0.4	neutral	0.31	neutral	0.45	neutral	1	0.61	neutral	0.44	neutral	-3	neutral	0.39	neutral	-0.98	medium_impact	0.25	medium_impact	0.16	medium_impact	0.41	0.8	5.64	13.54	0.34	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8632	8632	T	A	MI.225	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	106	36	Y	N	Tat/Aat	-10.05	0	0	benign	0.08	neutral	0.33	neutral	4.48	neutral	2.41	neutral	0.33	neutral_impact	-0.96	0.89	neutral	0.83	neutral	1.19	11.71	neutral	0.52	0.65	0.27	neutral	0.53	disease	0.28	neutral	0.47	neutral	1	0.63	neutral	0.63	deleterious	-6	neutral	0.19	neutral	0.25	medium_impact	0.12	medium_impact	-1.92	low_impact	0.37	0.9	29.2	23.72	0.35	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6079	6079	C	T	MI.2250	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	176	59	T	M	aCa/aTa	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.19	deleterious	-6.67	deleterious	-3.83	high_impact	4.62	0.76	neutral	0.11	damaging	3.91	23.50	deleterious	0.21	0.55	0.91	disease	0.78	disease	0.68	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.74	0.9	2.14	7.34	0.54	P	0.96	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13859	13859	C	T	MI.22500	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1523	508	T	I	aCc/aTc	-0.06	0	0	possibly_damaging	0.87	neutral	0.43	neutral	0.84	neutral	-1.95	deleterious	-4.33	medium_impact	2.64	0.72	neutral	0.62	neutral	3.65	23.20	deleterious	0.45	0.55	0.77	disease	0.69	disease	0.59	disease	0.63	disease	3	0.87	neutral	0.28	neutral	0	NA	0.63	deleterious	-1.53	low_impact	0.17	medium_impact	1.21	medium_impact	0.58	0.8	5.64	13.54	0.28	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13861	13861	A	C	MI.22501	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1525	509	N	H	Aac/Cac	-12.44	0	0	probably_damaging	0.96	neutral	0.59	neutral	0.91	neutral	-1.61	neutral	0.9	low_impact	1.55	0.83	neutral	0.99	neutral	1.83	15.18	deleterious	0.81	0.85	0.44	neutral	0.24	neutral	0.27	neutral	0.45	neutral	1	0.96	neutral	0.32	neutral	-2	neutral	0.62	deleterious	-2.06	low_impact	0.32	medium_impact	0.21	medium_impact	0.52	0.8	23.71	22.53	0.33	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13861	13861	A	T	MI.22502	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1525	509	N	Y	Aac/Tac	-12.44	0	0	probably_damaging	0.96	neutral	1	neutral	0.96	neutral	-0.43	neutral	1.33	medium_impact	2.41	0.85	neutral	0.96	neutral	2.39	18.75	deleterious	0.49	0.55	0.32	neutral	0.45	neutral	0.29	neutral	0.47	neutral	1	0.96	neutral	0.52	deleterious	1	deleterious	0.66	deleterious	-2.06	low_impact	1.89	high_impact	1	medium_impact	0.42	0.8	23.71	22.53	0.24	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13861	13861	A	G	MI.22503	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1525	509	N	D	Aac/Gac	-12.44	0	0	possibly_damaging	0.64	neutral	0.53	neutral	0.89	neutral	-2.32	neutral	-1.26	medium_impact	2.52	0.74	neutral	0.75	neutral	2.29	18.10	deleterious	0.82	0.85	0.34	neutral	0.41	neutral	0.43	neutral	0.47	neutral	1	0.6	neutral	0.45	neutral	0	NA	0.44	deleterious	-0.98	medium_impact	0.26	medium_impact	1.1	medium_impact	0.48	0.8	23.71	22.53	0.36	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13862	13862	A	C	MI.22504	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1526	509	N	T	aAc/aCc	-5.1	0	0	possibly_damaging	0.64	neutral	0.7	neutral	0.99	neutral	-0.06	neutral	-0.39	low_impact	1.49	0.85	neutral	0.88	neutral	0.59	8.07	deleterious	0.69	0.75	0.37	neutral	0.23	neutral	0.19	neutral	0.44	neutral	1	0.56	neutral	0.53	deleterious	-3	neutral	0.38	neutral	-0.98	medium_impact	0.44	medium_impact	0.16	medium_impact	0.44	0.8	23.71	22.53	0.36	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13862	13862	A	G	MI.22505	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1526	509	N	S	aAc/aGc	-5.1	0	0	benign	0.13	neutral	0.79	neutral	0.98	neutral	-0.25	neutral	-0.28	low_impact	1.75	0.82	neutral	0.91	neutral	-0.57	0.15	neutral	0.8	0.85	0.31	neutral	0.13	neutral	0.21	neutral	0.28	neutral	4	0.1	neutral	0.83	deleterious	-6	neutral	0.11	neutral	0.04	medium_impact	0.55	medium_impact	0.4	medium_impact	0.20	0.8	23.71	22.53	0.35	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13862	13862	A	T	MI.22506	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1526	509	N	I	aAc/aTc	-5.1	0	0	probably_damaging	0.93	neutral	0.49	neutral	0.95	neutral	-0.63	neutral	-0.59	medium_impact	2.32	0.85	neutral	0.66	neutral	3.95	23.60	deleterious	0.45	0.55	0.56	disease	0.48	neutral	0.39	neutral	0.61	disease	2	0.92	neutral	0.28	neutral	1	deleterious	0.64	deleterious	-1.81	low_impact	0.22	medium_impact	0.92	medium_impact	0.34	0.8	23.71	22.53	0.3	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13863	13863	C	A	MI.22507	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1527	509	N	K	aaC/aaA	-0.75	0	0	possibly_damaging	0.75	neutral	0.78	neutral	0.92	neutral	-1.27	neutral	-0.21	medium_impact	2.06	0.86	neutral	0.91	neutral	1.57	13.71	neutral	0.67	0.7	0.28	neutral	0.46	neutral	0.44	neutral	0.46	neutral	1	0.7	neutral	0.52	deleterious	0	NA	0.45	deleterious	-1.2	low_impact	0.54	medium_impact	0.68	medium_impact	0.43	0.8	23.71	22.53	0.24	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13863	13863	C	G	MI.22508	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1527	509	N	K	aaC/aaG	-0.75	0	0	possibly_damaging	0.75	neutral	0.78	neutral	0.92	neutral	-1.27	neutral	-0.21	medium_impact	2.06	0.86	neutral	0.91	neutral	1.09	11.17	neutral	0.67	0.7	0.28	neutral	0.46	neutral	0.44	neutral	0.46	neutral	1	0.7	neutral	0.52	deleterious	0	NA	0.45	deleterious	-1.2	low_impact	0.54	medium_impact	0.68	medium_impact	0.43	0.8	23.71	22.53	0.24	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13864	13864	A	C	MI.22509	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1528	510	K	Q	Aaa/Caa	-9.23	0	0	possibly_damaging	0.82	neutral	0.34	neutral	0.82	neutral	-1.69	neutral	0.06	medium_impact	2.04	0.8	neutral	0.82	neutral	2.15	17.21	deleterious	0.54	0.6	0.48	neutral	0.55	disease	0.49	neutral	0.49	neutral	0	0.84	neutral	0.26	neutral	0	NA	0.71	deleterious	-1.37	low_impact	0.07	medium_impact	0.66	medium_impact	0.72	0.85	15.59	12.75	0.36	N	0.71	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6081	6081	G	A	MI.2251	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	178	60	A	T	Gcc/Acc	-7.28	0	0	benign	0.41	deleterious	0	neutral	2.72	neutral	-1.14	neutral	-2.17	medium_impact	2.75	0.48	damaging	0.48	neutral	4.05	23.70	deleterious	0.28	0.55	0.38	neutral	0.85	disease	0.47	neutral	0.66	disease	3	1	deleterious	0.3	neutral	1	deleterious	0.57	deleterious	-0.61	medium_impact	-1.48	low_impact	1.44	medium_impact	0.67	0.9	6.63	22.87	0.5	P	0.20	polymorphism	0.94	0.09	.	.	.	.	.	.	.	.	0.15	G6081A	Prostate Cancer	+	-	Reported	1	.	P	P	damaging
chrM	13864	13864	A	G	MI.22510	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1528	510	K	E	Aaa/Gaa	-9.23	0	0	possibly_damaging	0.54	neutral	0.35	neutral	0.84	neutral	-1.39	neutral	-0.07	medium_impact	2.84	0.77	neutral	0.69	neutral	3.81	23.40	deleterious	0.5	0.6	0.42	neutral	0.72	disease	0.53	disease	0.61	disease	2	0.64	neutral	0.41	neutral	0	NA	0.74	deleterious	-0.81	medium_impact	0.08	medium_impact	1.39	medium_impact	0.82	0.85	15.59	12.75	0.35	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13865	13865	A	C	MI.22511	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1529	510	K	T	aAa/aCa	-0.06	0	0	possibly_damaging	0.45	neutral	0.47	neutral	0.83	neutral	-1.6	neutral	0.25	low_impact	1.68	0.85	neutral	0.96	neutral	2.70	20.80	deleterious	0.45	0.55	0.51	disease	0.47	neutral	0.34	neutral	0.43	neutral	1	0.49	neutral	0.51	deleterious	-3	neutral	0.72	deleterious	-0.66	medium_impact	0.2	medium_impact	0.33	medium_impact	0.68	0.85	15.59	12.75	0.37	N	0.57	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13865	13865	A	T	MI.22512	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1529	510	K	M	aAa/aTa	-0.06	0	0	probably_damaging	0.97	neutral	0.25	neutral	0.77	deleterious	-3.22	neutral	-1.18	medium_impact	2.84	0.78	neutral	0.67	neutral	4.11	23.70	deleterious	0.34	0.5	0.75	disease	0.61	disease	0.5	neutral	0.51	disease	0	0.97	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-2.18	low_impact	-0.03	medium_impact	1.39	medium_impact	0.44	0.8	15.59	12.75	0.34	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13866	13866	A	T	MI.22513	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1530	510	K	N	aaA/aaT	0.4	0	0	benign	0.02	neutral	0.37	neutral	0.87	neutral	-1.04	neutral	3.27	low_impact	1.02	0.88	neutral	0.97	neutral	1.80	14.97	neutral	0.63	0.65	0.35	neutral	0.38	neutral	0.32	neutral	0.46	neutral	1	0.61	neutral	0.68	deleterious	-6	neutral	0.70	deleterious	0.86	medium_impact	0.11	medium_impact	-0.27	medium_impact	0.86	0.9	15.59	12.75	0.35	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13866	13866	A	C	MI.22514	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1530	510	K	N	aaA/aaC	0.4	0	0	benign	0.02	neutral	0.37	neutral	0.87	neutral	-1.04	neutral	3.27	low_impact	1.02	0.88	neutral	0.97	neutral	1.74	14.61	neutral	0.63	0.65	0.35	neutral	0.38	neutral	0.32	neutral	0.46	neutral	1	0.61	neutral	0.68	deleterious	-6	neutral	0.70	deleterious	0.86	medium_impact	0.11	medium_impact	-0.27	medium_impact	0.86	0.9	15.59	12.75	0.35	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13867	13867	C	G	MI.22515	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1531	511	L	V	Ctt/Gtt	-4.42	0	0	benign	0.09	neutral	0.53	neutral	0.93	neutral	-0.91	neutral	-2.38	medium_impact	2.63	0.81	neutral	0.79	neutral	2.48	19.33	deleterious	0.61	0.65	0.64	disease	0.33	neutral	0.4	neutral	0.63	disease	3	0.39	neutral	0.72	deleterious	-3	neutral	0.75	deleterious	0.21	medium_impact	0.26	medium_impact	1.2	medium_impact	0.77	0.85	13.43	14.65	0.3	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13867	13867	C	T	MI.22516	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1531	511	L	F	Ctt/Ttt	-4.42	0	0	possibly_damaging	0.88	neutral	0.7	neutral	0.97	neutral	-0.32	deleterious	-3.05	low_impact	1.74	0.85	neutral	0.82	neutral	2.81	21.40	deleterious	0.62	0.65	0.59	disease	0.31	neutral	0.25	neutral	0.62	disease	2	0.86	neutral	0.41	neutral	-3	neutral	0.75	deleterious	-1.57	low_impact	0.44	medium_impact	0.39	medium_impact	0.65	0.8	13.43	14.65	0.25	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13867	13867	C	A	MI.22517	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1531	511	L	I	Ctt/Att	-4.42	0	0	benign	0.14	neutral	0.42	neutral	0.96	neutral	-0.43	neutral	-1.59	medium_impact	2.38	0.76	neutral	0.75	neutral	3.33	22.90	deleterious	0.51	0.6	0.64	disease	0.29	neutral	0.25	neutral	0.58	disease	2	0.51	neutral	0.64	deleterious	-3	neutral	0.74	deleterious	0	medium_impact	0.16	medium_impact	0.97	medium_impact	0.76	0.85	13.43	14.65	0.38	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13868	13868	T	A	MI.22518	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1532	511	L	H	cTt/cAt	-1.44	0	0	probably_damaging	0.98	neutral	0.56	neutral	0.87	neutral	-2.44	deleterious	-5.6	medium_impact	2.63	0.82	neutral	0.58	neutral	4.38	24.10	deleterious	0.32	0.5	0.57	disease	0.63	disease	0.33	neutral	0.53	disease	1	0.97	neutral	0.29	neutral	1	deleterious	0.79	deleterious	-2.35	low_impact	0.29	medium_impact	1.2	medium_impact	0.60	0.8	13.43	14.65	0.23	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13868	13868	T	G	MI.22519	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1532	511	L	R	cTt/cGt	-1.44	0	0	probably_damaging	0.93	neutral	0.37	neutral	0.88	neutral	-1.98	deleterious	-4.95	medium_impact	3.18	0.78	neutral	0.6	neutral	4.32	24.00	deleterious	0.36	0.5	0.71	disease	0.81	disease	0.54	disease	0.75	disease	5	0.94	neutral	0.22	neutral	1	deleterious	0.86	deleterious	-1.81	low_impact	0.11	medium_impact	1.7	medium_impact	0.55	0.8	13.43	14.65	0.29	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6081	6081	G	C	MI.2252	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	178	60	A	P	Gcc/Ccc	-7.28	0	0	possibly_damaging	0.83	deleterious	0	neutral	2.65	deleterious	-3.57	deleterious	-2.9	high_impact	4.59	0.59	damaging	0.43	neutral	3.71	23.30	deleterious	0.09	0.55	0.76	disease	0.9	disease	0.68	disease	0.76	disease	5	1	deleterious	0.09	neutral	5	deleterious	0.85	deleterious	-1.4	low_impact	-1.48	low_impact	3.14	high_impact	0.87	0.9	6.63	22.87	0.5	N	0.85	polymorphism	0.81	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13868	13868	T	C	MI.22520	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1532	511	L	P	cTt/cCt	-1.44	0	0	probably_damaging	0.95	neutral	0.23	neutral	0.88	neutral	-2.28	deleterious	-5.56	medium_impact	2.63	0.68	neutral	0.64	neutral	4.05	23.70	deleterious	0.42	0.55	0.68	disease	0.79	disease	0.35	neutral	0.59	disease	2	0.96	neutral	0.14	neutral	1	deleterious	0.86	deleterious	-1.96	low_impact	-0.06	medium_impact	1.2	medium_impact	0.59	0.8	13.43	14.65	0.33	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13870	13870	A	C	MI.22521	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1534	512	K	Q	Aaa/Caa	-3.04	0	0	probably_damaging	0.94	neutral	0.32	neutral	0.91	neutral	-0.96	neutral	-2.4	low_impact	1.81	0.86	neutral	0.45	neutral	2.51	19.53	deleterious	0.59	0.65	0.5	neutral	0.49	neutral	0.29	neutral	0.43	neutral	1	0.95	neutral	0.19	neutral	-2	neutral	0.74	deleterious	-1.88	low_impact	0.05	medium_impact	0.45	medium_impact	0.86	0.9	25.7	17.84	0.3	N	0.71	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13870	13870	A	G	MI.22522	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1534	512	K	E	Aaa/Gaa	-3.04	0	0	benign	0.3	neutral	0.32	neutral	0.93	neutral	-0.51	deleterious	-2.66	low_impact	1.66	0.79	neutral	0.26	damaging	4.10	23.70	deleterious	0.44	0.55	0.48	neutral	0.65	disease	0.48	neutral	0.52	disease	0	0.61	neutral	0.51	deleterious	-6	neutral	0.76	deleterious	-0.4	medium_impact	0.05	medium_impact	0.31	medium_impact	0.80	0.85	25.7	17.84	0.25	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13871	13871	A	T	MI.22523	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1535	512	K	M	aAa/aTa	2.69	0.08	0	probably_damaging	1	neutral	0.23	neutral	0.9	neutral	-2.51	deleterious	-4.11	medium_impact	2.02	0.84	neutral	0.9	neutral	4.06	23.70	deleterious	0.32	0.5	0.72	disease	0.47	neutral	0.3	neutral	0.62	disease	2	1	deleterious	0.12	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.06	medium_impact	0.64	medium_impact	0.58	0.8	25.7	17.84	0.46	N	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13871	13871	A	C	MI.22524	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1535	512	K	T	aAa/aCa	2.69	0.08	0	probably_damaging	0.97	neutral	0.42	neutral	0.97	neutral	-0.94	deleterious	-3.83	neutral_impact	0.28	0.83	neutral	0.92	neutral	2.60	20.20	deleterious	0.38	0.5	0.48	neutral	0.37	neutral	0.28	neutral	0.44	neutral	1	0.97	neutral	0.23	neutral	-2	neutral	0.72	deleterious	-2.18	low_impact	0.16	medium_impact	-0.95	medium_impact	0.84	0.9	25.7	17.84	0.35	N	0.80	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13872	13872	A	C	MI.22525	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1536	512	K	N	aaA/aaC	-0.06	0	0	probably_damaging	0.98	neutral	0.34	neutral	0.95	neutral	-1.22	deleterious	-3.13	low_impact	1.47	0.81	neutral	0.39	neutral	2.91	21.90	deleterious	0.62	0.65	0.59	disease	0.54	disease	0.31	neutral	0.51	disease	0	0.98	deleterious	0.18	neutral	-2	neutral	0.77	deleterious	-2.35	low_impact	0.07	medium_impact	0.14	medium_impact	0.94	0.95	25.7	17.84	0.29	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13872	13872	A	T	MI.22526	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1536	512	K	N	aaA/aaT	-0.06	0	0	probably_damaging	0.98	neutral	0.34	neutral	0.95	neutral	-1.22	deleterious	-3.13	low_impact	1.47	0.81	neutral	0.39	neutral	2.97	22.10	deleterious	0.62	0.65	0.59	disease	0.54	disease	0.31	neutral	0.51	disease	0	0.98	deleterious	0.18	neutral	-2	neutral	0.77	deleterious	-2.35	low_impact	0.07	medium_impact	0.14	medium_impact	0.94	0.95	25.7	17.84	0.29	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13873	13873	A	G	MI.22527	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1537	513	M	V	Ata/Gta	-0.29	0	0	benign	0	neutral	0.51	neutral	1.02	neutral	0.63	neutral	-0.79	low_impact	1.5	0.8	neutral	0.78	neutral	-0.96	0.02	neutral	0.71	0.75	0.42	neutral	0.26	neutral	0.43	neutral	0.44	neutral	1	0.48	neutral	0.76	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.24	medium_impact	0.17	medium_impact	0.56	0.8	31.67	19.84	0.34	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13873	13873	A	T	MI.22528	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1537	513	M	L	Ata/Tta	-0.29	0	0	benign	0	neutral	0.71	neutral	1.08	neutral	1.75	neutral	0.16	neutral_impact	-0.1	0.81	neutral	0.98	neutral	-0.63	0.11	neutral	0.67	0.7	0.54	disease	0.27	neutral	0.4	neutral	0.46	neutral	1	0.28	neutral	0.86	deleterious	-6	neutral	0.20	neutral	2.1	high_impact	0.45	medium_impact	-1.29	low_impact	0.63	0.8	31.67	19.84	0.39	N	0.26	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13873	13873	A	C	MI.22529	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1537	513	M	L	Ata/Cta	-0.29	0	0	benign	0	neutral	0.71	neutral	1.08	neutral	1.75	neutral	0.16	neutral_impact	-0.1	0.81	neutral	0.98	neutral	-0.71	0.07	neutral	0.67	0.7	0.54	disease	0.27	neutral	0.4	neutral	0.46	neutral	1	0.28	neutral	0.86	deleterious	-6	neutral	0.20	neutral	2.1	high_impact	0.45	medium_impact	-1.29	low_impact	0.63	0.8	31.67	19.84	0.38	N	0.26	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6081	6081	G	T	MI.2253	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	178	60	A	S	Gcc/Tcc	-7.28	0	0	benign	0.03	neutral	0.26	neutral	2.73	neutral	-0.87	neutral	-1.5	low_impact	0.94	0.53	damaging	0.6	neutral	2.40	18.82	deleterious	0.37	0.55	0.54	disease	0.7	disease	0.31	neutral	0.52	disease	0	0.73	neutral	0.62	deleterious	-6	neutral	0.30	neutral	0.66	medium_impact	-0.06	medium_impact	-0.23	medium_impact	0.91	0.95	6.63	22.87	0.42	N	0.64	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13874	13874	T	A	MI.22530	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1538	513	M	K	aTa/aAa	-3.96	0	0	benign	0.23	neutral	0.35	neutral	1.16	neutral	2.48	neutral	-1.86	neutral_impact	0.76	0.75	neutral	0.73	neutral	1.05	10.96	neutral	0.31	0.45	0.34	neutral	0.3	neutral	0.3	neutral	0.44	neutral	1	0.58	neutral	0.56	deleterious	-6	neutral	0.39	neutral	-0.25	medium_impact	0.08	medium_impact	-0.51	medium_impact	0.40	0.8	31.67	19.84	0.4	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13874	13874	T	C	MI.22531	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1538	513	M	T	aTa/aCa	-3.96	0	0	benign	0	neutral	0.45	neutral	1.04	neutral	1.11	neutral	-1.05	neutral_impact	0.73	0.84	neutral	0.94	neutral	-0.39	0.41	neutral	0.61	0.65	0.39	neutral	0.27	neutral	0.45	neutral	0.43	neutral	1	0.54	neutral	0.73	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.18	medium_impact	-0.54	medium_impact	0.09	0.8	31.67	19.84	0.33	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13875	13875	A	T	MI.22532	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1539	513	M	I	atA/atT	-1.21	0	0	benign	0.07	neutral	0.41	neutral	1.03	neutral	0.89	neutral	-0.47	neutral_impact	0.6	0.78	neutral	0.85	neutral	-0.05	2.15	deleterious	0.7	0.75	0.61	disease	0.22	neutral	0.43	neutral	0.43	neutral	2	0.54	neutral	0.67	deleterious	-6	neutral	0.26	neutral	0.32	medium_impact	0.15	medium_impact	-0.66	medium_impact	0.70	0.85	31.67	19.84	0.36	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13875	13875	A	C	MI.22533	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1539	513	M	I	atA/atC	-1.21	0	0	benign	0.07	neutral	0.41	neutral	1.03	neutral	0.89	neutral	-0.47	neutral_impact	0.6	0.78	neutral	0.85	neutral	-0.13	1.55	neutral	0.7	0.75	0.61	disease	0.22	neutral	0.43	neutral	0.43	neutral	2	0.54	neutral	0.67	deleterious	-6	neutral	0.26	neutral	0.32	medium_impact	0.15	medium_impact	-0.66	medium_impact	0.70	0.85	31.67	19.84	0.35	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13876	13876	A	G	MI.22534	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1540	514	K	E	Aaa/Gaa	-3.96	0	0	benign	0.35	neutral	0.33	neutral	0.86	neutral	-1.28	neutral	-1.14	low_impact	1.72	0.85	neutral	0.85	neutral	2.14	17.12	deleterious	0.47	0.55	0.38	neutral	0.58	disease	0.47	neutral	0.49	neutral	0	0.61	neutral	0.49	deleterious	-6	neutral	0.72	deleterious	-0.49	medium_impact	0.06	medium_impact	0.37	medium_impact	0.80	0.85	18.41	12.18	0.34	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13876	13876	A	C	MI.22535	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1540	514	K	Q	Aaa/Caa	-3.96	0	0	possibly_damaging	0.74	neutral	0.34	neutral	0.84	neutral	-1.61	neutral	-1.18	low_impact	0.94	0.8	neutral	0.86	neutral	1.98	16.08	deleterious	0.5	0.6	0.38	neutral	0.37	neutral	0.28	neutral	0.47	neutral	1	0.78	neutral	0.3	neutral	-3	neutral	0.69	deleterious	-1.18	low_impact	0.07	medium_impact	-0.34	medium_impact	0.77	0.85	18.41	12.18	0.39	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13877	13877	A	C	MI.22536	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1541	514	K	T	aAa/aCa	0.4	0	0	benign	0.35	neutral	0.48	neutral	0.84	neutral	-1.72	neutral	-1.7	neutral_impact	0.19	0.83	neutral	0.98	neutral	1.43	12.92	neutral	0.32	0.5	0.52	disease	0.26	neutral	0.28	neutral	0.37	neutral	3	0.44	neutral	0.57	deleterious	-6	neutral	0.70	deleterious	-0.49	medium_impact	0.21	medium_impact	-1.03	low_impact	0.70	0.85	18.41	12.18	0.38	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13877	13877	A	T	MI.22537	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1541	514	K	M	aAa/aTa	0.4	0	0	possibly_damaging	0.9	neutral	0.24	neutral	0.79	deleterious	-3.18	deleterious	-2.55	low_impact	0.82	0.84	neutral	0.96	neutral	2.76	21.10	deleterious	0.31	0.45	0.78	disease	0.35	neutral	0.31	neutral	0.65	disease	3	0.93	neutral	0.17	neutral	-3	neutral	0.73	deleterious	-1.65	low_impact	-0.04	medium_impact	-0.45	medium_impact	0.56	0.8	18.41	12.18	0.4	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13878	13878	A	C	MI.22538	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1542	514	K	N	aaA/aaC	-0.75	0	0	benign	0.03	neutral	0.35	neutral	0.87	neutral	-1.2	neutral	0.09	neutral_impact	0.36	0.9	neutral	0.99	neutral	1.94	15.86	deleterious	0.65	0.7	0.52	disease	0.39	neutral	0.3	neutral	0.39	neutral	2	0.63	neutral	0.66	deleterious	-6	neutral	0.72	deleterious	0.69	medium_impact	0.08	medium_impact	-0.87	medium_impact	0.87	0.9	18.41	12.18	0.42	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13878	13878	A	T	MI.22539	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1542	514	K	N	aaA/aaT	-0.75	0	0	benign	0.03	neutral	0.35	neutral	0.87	neutral	-1.2	neutral	0.09	neutral_impact	0.36	0.9	neutral	0.99	neutral	2.02	16.34	deleterious	0.65	0.7	0.52	disease	0.39	neutral	0.3	neutral	0.39	neutral	2	0.63	neutral	0.66	deleterious	-6	neutral	0.72	deleterious	0.69	medium_impact	0.08	medium_impact	-0.87	medium_impact	0.87	0.9	18.41	12.18	0.43	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6082	6082	C	T	MI.2254	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	179	60	A	V	gCc/gTc	7.3	1	0	benign	0.36	deleterious	0.01	neutral	2.87	neutral	0.47	neutral	-2.27	medium_impact	3.39	0.55	damaging	0.39	neutral	4.29	24.00	deleterious	0.28	0.55	0.35	neutral	0.91	disease	0.54	disease	0.73	disease	5	0.99	deleterious	0.33	neutral	1	deleterious	0.65	deleterious	-0.52	medium_impact	-0.92	medium_impact	2.03	high_impact	0.82	0.9	6.63	22.87	0.49	P	0.75	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13879	13879	T	G	MI.22540	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1543	515	S	A	Tcc/Gcc	-7.4	0	0.03	benign	0	neutral	0.54	neutral	0.92	neutral	-0.83	neutral	-0.62	low_impact	1.32	0.84	neutral	0.88	neutral	0.35	6.19	deleterious	0.48	0.55	0.42	neutral	0.15	neutral	0.31	neutral	0.28	neutral	4	0.45	neutral	0.77	deleterious	-6	neutral	0.16	neutral	2.1	high_impact	0.27	medium_impact	0	medium_impact	0.39	0.8	31.01	22.72	0.35	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13879	13879	T	C	MI.22541	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1543	515	S	P	Tcc/Ccc	-7.4	0	0.03	benign	0.01	neutral	0.25	neutral	0.85	neutral	-2.07	neutral	-0.76	neutral_impact	-0.86	0.89	neutral	0.96	neutral	-0.16	1.34	neutral	0.37	0.5	0.44	neutral	0.44	neutral	0.22	neutral	0.47	neutral	1	0.75	neutral	0.62	deleterious	-6	neutral	0.20	neutral	1.15	medium_impact	-0.03	medium_impact	-1.99	low_impact	0.49	0.8	31.01	22.72	0.4	N	0.52	polymorphism	1	0.02	rs879087566	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13879	13879	T	A	MI.22542	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1543	515	S	T	Tcc/Acc	-7.4	0	0.03	benign	0	neutral	0.43	neutral	0.95	neutral	-0.44	neutral	-0.16	neutral_impact	-0.06	0.89	neutral	0.95	neutral	-0.23	0.95	neutral	0.47	0.55	0.39	neutral	0.08	neutral	0.16	neutral	0.25	neutral	5	0.57	neutral	0.72	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.17	medium_impact	-1.26	low_impact	0.70	0.85	31.01	22.72	0.58	P	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13880	13880	C	A	MI.22543	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1544	515	S	Y	tCc/tAc	-2.12	0	0	benign	0.17	neutral	1	neutral	0.84	neutral	-2.46	neutral	1.26	low_impact	0.9	0.91	neutral	0.98	neutral	-0.21	1.04	neutral	0.31	0.45	0.48	neutral	0.4	neutral	0.25	neutral	0.41	neutral	2	0.17	neutral	0.92	deleterious	-6	neutral	0.34	neutral	-0.09	medium_impact	1.89	high_impact	-0.38	medium_impact	0.49	0.8	31.01	22.72	0.22	N	0.02	polymorphism	1	0.01	rs28359181	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13880	13880	C	T	MI.22544	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1544	515	S	F	tCc/tTc	-2.12	0	0	benign	0.23	neutral	0.71	neutral	0.85	neutral	-2.11	neutral	-0.23	low_impact	1.32	0.84	neutral	0.64	neutral	0.85	9.78	deleterious	0.31	0.5	0.45	neutral	0.51	disease	0.39	neutral	0.51	disease	0	0.19	neutral	0.74	deleterious	-6	neutral	0.53	deleterious	-0.25	medium_impact	0.45	medium_impact	0	medium_impact	0.35	0.8	31.01	22.72	0.24	N	0.33	polymorphism	1	0.01	rs28359181	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13880	13880	C	G	MI.22545	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1544	515	S	C	tCc/tGc	-2.12	0	0	possibly_damaging	0.68	neutral	0.18	neutral	0.81	deleterious	-4.4	neutral	-1.52	low_impact	1.87	0.84	neutral	0.55	neutral	2.28	18.04	deleterious	0.39	0.5	0.87	disease	0.53	disease	0.38	neutral	0.61	disease	2	0.85	neutral	0.25	neutral	-3	neutral	0.66	deleterious	-1.06	low_impact	-0.13	medium_impact	0.51	medium_impact	0.55	0.8	31.01	22.72	0.36	N	0.49	polymorphism	1	0.03	rs28359181	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13882	13882	C	G	MI.22546	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1546	516	P	A	Cca/Gca	-5.33	0	0	possibly_damaging	0.64	neutral	0.55	neutral	1	neutral	0.4	deleterious	-4.12	low_impact	1.61	0.86	neutral	0.9	neutral	1.71	14.49	neutral	0.45	0.55	0.44	neutral	0.37	neutral	0.38	neutral	0.46	neutral	1	0.6	neutral	0.46	neutral	-3	neutral	0.51	deleterious	-0.98	medium_impact	0.28	medium_impact	0.27	medium_impact	0.82	0.85	21.23	16.75	0.29	N	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13882	13882	C	T	MI.22547	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1546	516	P	S	Cca/Tca	-5.33	0	0	benign	0.26	neutral	0.45	neutral	0.98	neutral	0.3	deleterious	-3.6	low_impact	0.88	0.87	neutral	0.97	neutral	2.50	19.49	deleterious	0.55	0.6	0.42	neutral	0.55	disease	0.22	neutral	0.45	neutral	1	0.46	neutral	0.6	deleterious	-6	neutral	0.58	deleterious	-0.32	medium_impact	0.18	medium_impact	-0.4	medium_impact	0.28	0.8	21.23	16.75	0.34	N	0.26	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13882	13882	C	A	MI.22548	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1546	516	P	T	Cca/Aca	-5.33	0	0	benign	0.2	neutral	0.43	neutral	0.98	neutral	0.05	deleterious	-3.68	low_impact	1.61	0.87	neutral	0.89	neutral	0.60	8.17	deleterious	0.48	0.55	0.53	disease	0.5	neutral	0.23	neutral	0.43	neutral	1	0.48	neutral	0.62	deleterious	-6	neutral	0.20	neutral	-0.17	medium_impact	0.17	medium_impact	0.27	medium_impact	0.79	0.85	21.23	16.75	0.34	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13883	13883	C	A	MI.22549	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1547	516	P	Q	cCa/cAa	-0.98	0	0	probably_damaging	0.96	neutral	0.33	neutral	0.96	neutral	-0.08	deleterious	-4.06	low_impact	1.26	0.83	neutral	0.76	neutral	4.07	23.70	deleterious	0.35	0.5	0.49	neutral	0.58	disease	0.32	neutral	0.46	neutral	1	0.96	neutral	0.19	neutral	-2	neutral	0.71	deleterious	-2.06	low_impact	0.06	medium_impact	-0.05	medium_impact	0.55	0.8	21.23	16.75	0.31	N	0.68	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6082	6082	C	A	MI.2255	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	179	60	A	D	gCc/gAc	7.3	1	0	possibly_damaging	0.62	deleterious	0	neutral	2.65	deleterious	-4.13	deleterious	-3.4	high_impact	4.25	0.65	neutral	0.42	neutral	4.50	24.30	deleterious	0.12	0.55	0.78	disease	0.93	disease	0.66	disease	0.79	disease	6	1	deleterious	0.19	neutral	5	deleterious	0.71	deleterious	-0.96	medium_impact	-1.48	low_impact	2.83	high_impact	0.74	0.9	6.63	22.87	0.55	P	0.89	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13883	13883	C	T	MI.22550	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1547	516	P	L	cCa/cTa	-0.98	0	0	possibly_damaging	0.83	neutral	0.68	neutral	1.08	neutral	-0.45	deleterious	-5.71	low_impact	1	0.84	neutral	0.72	neutral	3.03	22.30	deleterious	0.5	0.6	0.34	neutral	0.68	disease	0.38	neutral	0.48	neutral	0	0.8	neutral	0.43	neutral	-3	neutral	0.58	deleterious	-1.4	low_impact	0.41	medium_impact	-0.29	medium_impact	0.73	0.85	21.23	16.75	0.22	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13883	13883	C	G	MI.22551	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1547	516	P	R	cCa/cGa	-0.98	0	0	probably_damaging	0.96	neutral	0.37	neutral	0.93	neutral	-0.32	deleterious	-4.75	low_impact	1.84	0.83	neutral	0.62	neutral	3.62	23.20	deleterious	0.43	0.55	0.5	disease	0.78	disease	0.42	neutral	0.63	disease	3	0.96	neutral	0.21	neutral	-2	neutral	0.73	deleterious	-2.06	low_impact	0.11	medium_impact	0.48	medium_impact	0.58	0.8	21.23	16.75	0.26	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13885	13885	C	A	MI.22552	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1549	517	L	M	Cta/Ata	-9	0	0	benign	0.08	neutral	0.22	neutral	0.97	neutral	-0.76	neutral	0.62	low_impact	0.9	0.8	neutral	0.83	neutral	2.25	17.86	deleterious	0.31	0.45	0.72	disease	0.22	neutral	0.18	neutral	0.52	disease	0	0.76	neutral	0.57	deleterious	-6	neutral	0.61	deleterious	0.26	medium_impact	-0.07	medium_impact	-0.38	medium_impact	0.72	0.85	29.85	17.09	0.46	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13885	13885	C	G	MI.22553	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1549	517	L	V	Cta/Gta	-9	0	0	benign	0.01	neutral	0.5	neutral	0.98	neutral	-0.56	neutral	0.03	neutral_impact	0.64	0.81	neutral	0.85	neutral	-0.10	1.75	neutral	0.35	0.5	0.54	disease	0.29	neutral	0.32	neutral	0.5	neutral	0	0.49	neutral	0.75	deleterious	-6	neutral	0.33	neutral	1.15	medium_impact	0.23	medium_impact	-0.62	medium_impact	0.49	0.8	29.85	17.09	0.32	N	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13886	13886	T	G	MI.22554	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1550	517	L	R	cTa/cGa	-2.35	0	0.01	possibly_damaging	0.47	neutral	0.35	neutral	1.01	neutral	0.11	neutral	0.64	low_impact	1.09	0.74	neutral	0.73	neutral	0.95	10.39	neutral	0.32	0.5	0.31	neutral	0.75	disease	0.47	neutral	0.59	disease	2	0.61	neutral	0.44	neutral	-3	neutral	0.46	deleterious	-0.7	medium_impact	0.08	medium_impact	-0.21	medium_impact	0.49	0.8	29.85	17.09	0.34	N	0.21	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13886	13886	T	C	MI.22555	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1550	517	L	P	cTa/cCa	-2.35	0	0.01	benign	0.01	neutral	0.21	neutral	0.98	neutral	-0.59	neutral	0.23	neutral_impact	0.34	0.9	neutral	0.78	neutral	0.82	9.59	deleterious	0.22	0.45	0.41	neutral	0.73	disease	0.25	neutral	0.5	neutral	0	0.79	neutral	0.6	deleterious	-6	neutral	0.24	neutral	1.15	medium_impact	-0.09	medium_impact	-0.89	medium_impact	0.43	0.8	29.85	17.09	0.35	N	0.02	polymorphism	1	0.01	rs28359182	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13886	13886	T	A	MI.22556	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1550	517	L	Q	cTa/cAa	-2.35	0	0.01	possibly_damaging	0.55	neutral	0.3	neutral	1.01	neutral	0.3	neutral	1.33	low_impact	0.82	0.86	neutral	0.94	neutral	1.19	11.70	neutral	0.3	0.45	0.41	neutral	0.56	disease	0.24	neutral	0.45	neutral	1	0.69	neutral	0.38	neutral	-3	neutral	0.45	deleterious	-0.83	medium_impact	0.03	medium_impact	-0.45	medium_impact	0.48	0.8	29.85	17.09	0.35	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13888	13888	T	A	MI.22557	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1552	518	C	S	Tgc/Agc	-7.4	0	0	benign	0	neutral	0.41	neutral	1.13	neutral	3.99	neutral	2.16	neutral_impact	-1.62	0.85	neutral	0.91	neutral	-0.11	1.64	neutral	0.42	0.55	0.23	neutral	0.18	neutral	0.17	neutral	0.29	neutral	4	0.59	neutral	0.71	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.15	medium_impact	-2.68	low_impact	0.48	0.8	31.51	23.2	0.42	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13888	13888	T	G	MI.22558	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1552	518	C	G	Tgc/Ggc	-7.4	0	0	benign	0	neutral	0.34	neutral	1.03	neutral	2.24	neutral	0.67	neutral_impact	-0.55	0.81	neutral	0.82	neutral	-0.08	1.88	neutral	0.31	0.5	0.3	neutral	0.31	neutral	0.36	neutral	0.43	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.07	medium_impact	-1.71	low_impact	0.36	0.8	31.51	23.2	0.31	N	0.24	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13888	13888	T	C	MI.22559	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1552	518	C	R	Tgc/Cgc	-7.4	0	0	benign	0	neutral	0.34	neutral	1.06	neutral	2.91	neutral	2.18	neutral_impact	-0.34	0.86	neutral	0.93	neutral	0.05	3.07	deleterious	0.29	0.45	0.27	neutral	0.55	disease	0.39	neutral	0.43	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.17	neutral	2.1	high_impact	0.07	medium_impact	-1.51	low_impact	0.21	0.8	31.51	23.2	0.28	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6082	6082	C	G	MI.2256	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	179	60	A	G	gCc/gGc	7.3	1	0	benign	0.17	deleterious	0	neutral	2.69	neutral	-1.94	neutral	-2.3	medium_impact	2.92	0.56	damaging	0.61	neutral	3.84	23.40	deleterious	0.19	0.55	0.41	neutral	0.8	disease	0.35	neutral	0.53	disease	1	1	deleterious	0.42	neutral	1	deleterious	0.34	neutral	-0.11	medium_impact	-1.48	low_impact	1.6	medium_impact	0.81	0.9	6.63	22.87	0.53	P	0.56	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13889	13889	G	T	MI.22560	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1553	518	C	F	tGc/tTc	-1.21	0	0.01	benign	0	neutral	0.72	neutral	1.04	neutral	2.52	neutral	0.01	neutral_impact	-0.7	0.77	neutral	0.81	neutral	-0.10	1.74	neutral	0.31	0.5	0.4	neutral	0.41	neutral	0.32	neutral	0.45	neutral	1	0.28	neutral	0.86	deleterious	-6	neutral	0.15	neutral	2.1	high_impact	0.46	medium_impact	-1.84	low_impact	0.50	0.8	31.51	23.2	0.3	N	0.15	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13889	13889	G	A	MI.22561	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1553	518	C	Y	tGc/tAc	-1.21	0	0.01	benign	0	neutral	1	neutral	1.03	neutral	2.14	neutral	1.14	neutral_impact	-0.7	0.9	neutral	0.88	neutral	-0.87	0.03	neutral	0.37	0.5	0.58	disease	0.39	neutral	0.2	neutral	0.58	disease	2	0	neutral	1	deleterious	-6	neutral	0.18	neutral	2.1	high_impact	1.89	high_impact	-1.84	low_impact	0.56	0.8	31.51	23.2	0.29	N	0.06	polymorphism	1	0.00	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13889	13889	G	C	MI.22562	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1553	518	C	S	tGc/tCc	-1.21	0	0.01	benign	0	neutral	0.41	neutral	1.13	neutral	3.99	neutral	2.16	neutral_impact	-1.62	0.85	neutral	0.91	neutral	-0.42	0.34	neutral	0.42	0.55	0.23	neutral	0.18	neutral	0.17	neutral	0.29	neutral	4	0.59	neutral	0.71	deleterious	-6	neutral	0.12	neutral	2.1	high_impact	0.15	medium_impact	-2.68	low_impact	0.48	0.8	31.51	23.2	0.42	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13890	13890	C	G	MI.22563	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1554	518	C	W	tgC/tgG	-2.12	0	0	benign	0.01	neutral	0.18	neutral	1	neutral	-0.74	neutral	-0.41	neutral_impact	0	0.78	neutral	0.63	neutral	1.17	11.58	neutral	0.28	0.45	0.64	disease	0.51	disease	0.39	neutral	0.48	neutral	0	0.82	neutral	0.59	deleterious	-6	neutral	0.21	neutral	1.15	medium_impact	-0.13	medium_impact	-1.2	low_impact	0.39	0.8	31.51	23.2	0.33	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13890	13890	C	A	MI.22564	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1554	518	C	W	tgC/tgA	-2.12	0	0	benign	0.01	neutral	0.18	neutral	1	neutral	-0.74	neutral	-0.41	neutral_impact	0	0.78	neutral	0.63	neutral	1.46	13.08	neutral	0.28	0.45	0.64	disease	0.51	disease	0.39	neutral	0.48	neutral	0	0.82	neutral	0.59	deleterious	-6	neutral	0.21	neutral	1.15	medium_impact	-0.13	medium_impact	-1.2	low_impact	0.39	0.8	31.51	23.2	0.33	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13891	13891	A	C	MI.22565	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1555	519	T	P	Aca/Cca	-3.5	0	0	benign	0.03	neutral	0.25	neutral	0.95	neutral	-0.91	neutral	-0.82	low_impact	0.95	0.83	neutral	0.98	neutral	1.51	13.39	neutral	0.18	0.45	0.59	disease	0.48	neutral	0.42	neutral	0.58	disease	2	0.74	neutral	0.61	deleterious	-6	neutral	0.63	deleterious	0.69	medium_impact	-0.03	medium_impact	-0.34	medium_impact	0.61	0.8	20.56	13.16	0.37	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13891	13891	A	T	MI.22566	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1555	519	T	S	Aca/Tca	-3.5	0	0	benign	0.27	neutral	0.51	neutral	1.01	neutral	0.08	neutral	-0.79	neutral_impact	0.68	0.84	neutral	0.98	neutral	-0.14	1.46	neutral	0.48	0.55	0.51	disease	0.26	neutral	0.26	neutral	0.36	neutral	3	0.39	neutral	0.62	deleterious	-6	neutral	0.39	neutral	-0.34	medium_impact	0.24	medium_impact	-0.58	medium_impact	0.55	0.8	20.56	13.16	0.38	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13891	13891	A	G	MI.22567	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1555	519	T	A	Aca/Gca	-3.5	0	0	benign	0.02	neutral	0.61	neutral	0.99	neutral	-0.18	neutral	-1.21	low_impact	1.26	0.84	neutral	0.97	neutral	-0.30	0.67	neutral	0.54	0.6	0.27	neutral	0.26	neutral	0.45	neutral	0.43	neutral	1	0.36	neutral	0.8	deleterious	-6	neutral	0.11	neutral	0.86	medium_impact	0.34	medium_impact	-0.05	medium_impact	0.29	0.8	20.56	13.16	0.32	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13892	13892	C	T	MI.22568	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1556	519	T	M	aCa/aTa	-10.83	0	0	benign	0.05	neutral	0.24	neutral	0.98	neutral	-0.28	neutral	-1.16	low_impact	1.6	0.87	neutral	0.97	neutral	0.67	8.60	deleterious	0.35	0.5	0.45	neutral	0.37	neutral	0.32	neutral	0.48	neutral	0	0.74	neutral	0.6	deleterious	-6	neutral	0.27	neutral	0.47	medium_impact	-0.04	medium_impact	0.26	medium_impact	0.67	0.85	20.56	13.16	0.42	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13892	13892	C	A	MI.22569	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1556	519	T	K	aCa/aAa	-10.83	0	0	possibly_damaging	0.46	neutral	0.43	neutral	0.91	neutral	-2.1	neutral	-1.8	medium_impact	2.03	0.79	neutral	0.75	neutral	1.57	13.68	neutral	0.29	0.45	0.58	disease	0.67	disease	0.61	disease	0.56	disease	1	0.53	neutral	0.49	deleterious	0	NA	0.57	deleterious	-0.68	medium_impact	0.17	medium_impact	0.65	medium_impact	0.57	0.8	20.56	13.16	0.25	N	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6084	6084	C	A	MI.2257	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	181	61	H	N	Cat/Aat	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	-1.17	deleterious	-10.98	deleterious	-4.46	high_impact	5.19	0.53	damaging	0.02	damaging	3.89	23.50	deleterious	0.28	0.55	0.77	disease	0.84	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.44	0.9	2.92	6.76	0.49	N	0.86	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13894	13894	T	G	MI.22570	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1558	520	F	V	Ttt/Gtt	-4.42	0	0	probably_damaging	0.91	neutral	0.53	neutral	1.02	neutral	0.37	deleterious	-2.9	medium_impact	2.29	0.79	neutral	0.29	neutral	2.98	22.20	deleterious	0.33	0.5	0.45	neutral	0.72	disease	0.63	disease	0.71	disease	4	0.9	neutral	0.31	neutral	1	deleterious	0.74	deleterious	-1.7	low_impact	0.26	medium_impact	0.89	medium_impact	0.52	0.8	28.19	17.59	0.17	N	0.80	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13894	13894	T	C	MI.22571	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1558	520	F	L	Ttt/Ctt	-4.42	0	0	possibly_damaging	0.81	neutral	0.71	neutral	1.03	neutral	0.52	deleterious	-2.65	low_impact	1.08	0.81	neutral	0.81	neutral	2.67	20.60	deleterious	0.36	0.5	0.44	neutral	0.52	disease	0.48	neutral	0.49	neutral	0	0.78	neutral	0.45	neutral	-3	neutral	0.71	deleterious	-1.34	low_impact	0.45	medium_impact	-0.22	medium_impact	0.70	0.85	28.19	17.59	0.21	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13894	13894	T	A	MI.22572	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1558	520	F	I	Ttt/Att	-4.42	0	0	probably_damaging	0.94	neutral	0.42	neutral	1	neutral	0.04	deleterious	-2.65	low_impact	1.48	0.82	neutral	0.82	neutral	3.37	22.90	deleterious	0.2	0.45	0.54	disease	0.63	disease	0.61	disease	0.69	disease	4	0.93	neutral	0.24	neutral	-2	neutral	0.76	deleterious	-1.88	low_impact	0.16	medium_impact	0.15	medium_impact	0.52	0.8	28.19	17.59	0.26	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13895	13895	T	G	MI.22573	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1559	520	F	C	tTt/tGt	-2.35	0	0	probably_damaging	0.99	neutral	0.17	neutral	0.95	neutral	-2.57	deleterious	-3.61	low_impact	1.94	0.71	neutral	0.2	damaging	4.18	23.80	deleterious	0.28	0.45	0.82	disease	0.83	disease	0.64	disease	0.8	disease	6	0.99	deleterious	0.09	neutral	-2	neutral	0.82	deleterious	-2.64	low_impact	-0.15	medium_impact	0.57	medium_impact	0.26	0.8	28.19	17.59	0.23	N	0.79	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13895	13895	T	A	MI.22574	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1559	520	F	Y	tTt/tAt	-2.35	0	0	benign	0.12	neutral	1	neutral	1	neutral	-0.04	neutral	0.1	neutral_impact	-0.48	0.8	neutral	0.95	neutral	2.79	21.30	deleterious	0.34	0.5	0.24	neutral	0.46	neutral	0.27	neutral	0.46	neutral	1	0.11	neutral	0.94	deleterious	-6	neutral	0.70	deleterious	0.08	medium_impact	1.89	high_impact	-1.64	low_impact	0.58	0.8	28.19	17.59	0.24	N	0.70	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13895	13895	T	C	MI.22575	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1559	520	F	S	tTt/tCt	-2.35	0	0	probably_damaging	0.97	neutral	0.49	neutral	1.12	neutral	1.56	deleterious	-2.67	low_impact	0.93	0.82	neutral	0.96	neutral	3.12	22.60	deleterious	0.41	0.5	0.35	neutral	0.63	disease	0.43	neutral	0.49	neutral	0	0.97	neutral	0.26	neutral	-2	neutral	0.73	deleterious	-2.18	low_impact	0.22	medium_impact	-0.35	medium_impact	0.44	0.8	28.19	17.59	0.3	N	0.38	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13896	13896	T	G	MI.22576	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1560	520	F	L	ttT/ttG	-4.87	0	0	possibly_damaging	0.81	neutral	0.71	neutral	1.03	neutral	0.52	deleterious	-2.65	low_impact	1.08	0.81	neutral	0.81	neutral	3.04	22.40	deleterious	0.36	0.5	0.44	neutral	0.52	disease	0.48	neutral	0.49	neutral	0	0.78	neutral	0.45	neutral	-3	neutral	0.71	deleterious	-1.34	low_impact	0.45	medium_impact	-0.22	medium_impact	0.70	0.85	28.19	17.59	0.21	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13896	13896	T	A	MI.22577	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1560	520	F	L	ttT/ttA	-4.87	0	0	possibly_damaging	0.81	neutral	0.71	neutral	1.03	neutral	0.52	deleterious	-2.65	low_impact	1.08	0.81	neutral	0.81	neutral	3.11	22.50	deleterious	0.36	0.5	0.44	neutral	0.52	disease	0.48	neutral	0.49	neutral	0	0.78	neutral	0.45	neutral	-3	neutral	0.71	deleterious	-1.34	low_impact	0.45	medium_impact	-0.22	medium_impact	0.70	0.85	28.19	17.59	0.21	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13897	13897	T	A	MI.22578	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1561	521	Y	N	Tat/Aat	-4.64	0	0	benign	0.01	neutral	0.34	neutral	1.07	neutral	0.96	neutral	1.95	neutral_impact	-0.79	0.86	neutral	0.97	neutral	-0.24	0.89	neutral	0.44	0.55	0.32	neutral	0.29	neutral	0.26	neutral	0.45	neutral	1	0.65	neutral	0.67	deleterious	-6	neutral	0.36	neutral	1.15	medium_impact	0.07	medium_impact	-1.92	low_impact	0.32	0.8	31.18	20.07	0.31	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13897	13897	T	C	MI.22579	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1561	521	Y	H	Tat/Cat	-4.64	0	0	benign	0.02	neutral	0.55	neutral	1.02	neutral	0.31	neutral	0.57	neutral_impact	0.14	0.74	neutral	0.9	neutral	-1.00	0.02	neutral	0.62	0.65	0.46	neutral	0.12	neutral	0.26	neutral	0.24	neutral	5	0.43	neutral	0.77	deleterious	-6	neutral	0.14	neutral	0.86	medium_impact	0.28	medium_impact	-1.08	low_impact	0.37	0.8	31.18	20.07	0.38	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6084	6084	C	G	MI.2258	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	181	61	H	D	Cat/Gat	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	-1.17	deleterious	-12.35	deleterious	-5.74	high_impact	5.19	0.48	damaging	0.02	damaging	3.75	23.30	deleterious	0.2	0.55	0.37	neutral	0.88	disease	0.81	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.39	0.9	2.92	6.76	0.42	N	0.97	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13897	13897	T	G	MI.22580	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1561	521	Y	D	Tat/Gat	-4.64	0	0	benign	0.26	neutral	0.26	neutral	0.97	neutral	-0.84	neutral	0.18	neutral_impact	0.76	0.8	neutral	0.78	neutral	2.41	18.86	deleterious	0.36	0.5	0.3	neutral	0.65	disease	0.58	disease	0.68	disease	4	0.69	neutral	0.5	deleterious	-6	neutral	0.47	deleterious	-0.32	medium_impact	-0.02	medium_impact	-0.51	medium_impact	0.42	0.8	31.18	20.07	0.3	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13898	13898	A	C	MI.22581	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1562	521	Y	S	tAt/tCt	0.17	0	0	benign	0.18	neutral	0.47	neutral	1.12	neutral	1.35	neutral	1.22	neutral_impact	-0.12	0.87	neutral	0.96	neutral	0.80	9.46	deleterious	0.36	0.5	0.22	neutral	0.41	neutral	0.33	neutral	0.44	neutral	1	0.44	neutral	0.65	deleterious	-6	neutral	0.42	neutral	-0.12	medium_impact	0.2	medium_impact	-1.31	low_impact	0.33	0.8	31.18	20.07	0.3	N	0.15	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13898	13898	A	G	MI.22582	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1562	521	Y	C	tAt/tGt	0.17	0	0	possibly_damaging	0.89	neutral	0.18	neutral	0.93	neutral	-2.88	neutral	-1.15	low_impact	1.79	0.72	neutral	0.42	neutral	3.63	23.20	deleterious	0.4	0.5	0.84	disease	0.71	disease	0.51	disease	0.67	disease	3	0.94	neutral	0.15	neutral	-3	neutral	0.74	deleterious	-1.61	low_impact	-0.13	medium_impact	0.43	medium_impact	0.15	0.8	31.18	20.07	0.32	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13898	13898	A	T	MI.22583	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1562	521	Y	F	tAt/tTt	0.17	0	0	benign	0.41	neutral	0.73	neutral	1	neutral	-0.08	neutral	-0.78	low_impact	1.1	0.78	neutral	0.86	neutral	0.78	9.31	deleterious	0.47	0.55	0.63	disease	0.37	neutral	0.39	neutral	0.62	disease	2	0.31	neutral	0.66	deleterious	-6	neutral	0.50	deleterious	-0.6	medium_impact	0.47	medium_impact	-0.2	medium_impact	0.41	0.8	31.18	20.07	0.28	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13900	13900	T	A	MI.22584	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1564	522	F	I	Ttc/Atc	-1.89	0	0	probably_damaging	1	neutral	0.41	neutral	0.35	deleterious	-3.46	deleterious	-5.13	medium_impact	3.4	0.55	damaging	0.15	damaging	4.74	24.70	deleterious	0.18	0.45	0.47	neutral	0.81	disease	0.72	disease	0.74	disease	5	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.15	medium_impact	1.9	medium_impact	0.61	0.8	28.86	7.21	0.29	N	0.95	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13900	13900	T	G	MI.22585	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1564	522	F	V	Ttc/Gtc	-1.89	0	0	probably_damaging	1	neutral	0.51	neutral	0.37	deleterious	-3.18	deleterious	-5.97	high_impact	3.75	0.61	neutral	0.08	damaging	4.35	24.10	deleterious	0.35	0.5	0.53	disease	0.85	disease	0.78	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.24	medium_impact	2.22	high_impact	0.62	0.8	28.86	7.21	0.32	N	0.95	polymorphism	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13900	13900	T	C	MI.22586	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1564	522	F	L	Ttc/Ctc	-1.89	0	0	probably_damaging	1	neutral	0.67	neutral	0.4	neutral	-2.8	deleterious	-5.13	medium_impact	2.23	0.54	damaging	0.14	damaging	4.36	24.10	deleterious	0.41	0.5	0.52	disease	0.74	disease	0.7	disease	0.55	disease	1	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.4	medium_impact	0.83	medium_impact	0.61	0.8	28.86	7.21	0.16	N	0.92	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13901	13901	T	A	MI.22587	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1565	522	F	Y	tTc/tAc	4.52	1	0	probably_damaging	1	neutral	1	neutral	0.33	deleterious	-3.92	deleterious	-2.61	medium_impact	3.2	0.63	neutral	0.1	damaging	4.42	24.20	deleterious	0.39	0.5	0.78	disease	0.74	disease	0.71	disease	0.74	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.82	deleterious	-3.6	low_impact	1.89	high_impact	1.72	medium_impact	0.62	0.8	28.86	7.21	0.42	N	0.88	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13901	13901	T	G	MI.22588	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1565	522	F	C	tTc/tGc	4.52	1	0	probably_damaging	1	neutral	0.18	neutral	0.29	deleterious	-5.8	deleterious	-6.79	high_impact	3.75	0.61	neutral	0.06	damaging	4.27	24.00	deleterious	0.24	0.45	0.86	disease	0.87	disease	0.78	disease	0.86	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.13	medium_impact	2.22	high_impact	0.34	0.8	28.86	7.21	0.48	N	0.99	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13901	13901	T	C	MI.22589	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1565	522	F	S	tTc/tCc	4.52	1	0	probably_damaging	1	neutral	0.43	neutral	0.34	deleterious	-3.7	deleterious	-6.76	medium_impact	3.06	0.57	damaging	0.1	damaging	4.40	24.10	deleterious	0.34	0.5	0.66	disease	0.83	disease	0.74	disease	0.77	disease	5	1	deleterious	0.22	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.17	medium_impact	1.59	medium_impact	0.52	0.8	28.86	7.21	0.39	N	0.97	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6084	6084	C	T	MI.2259	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	181	61	H	Y	Cat/Tat	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	-1.17	deleterious	-10.99	deleterious	-3.83	high_impact	4.84	0.56	damaging	0.02	damaging	3.64	23.20	deleterious	0.29	0.55	0.92	disease	0.91	disease	0.75	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.35	0.9	2.92	6.76	0.54	P	0.72	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13902	13902	C	G	MI.22590	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1566	522	F	L	ttC/ttG	3.61	1	0	probably_damaging	1	neutral	0.67	neutral	0.4	neutral	-2.8	deleterious	-5.13	medium_impact	2.23	0.54	damaging	0.14	damaging	4.56	24.40	deleterious	0.41	0.5	0.52	disease	0.74	disease	0.7	disease	0.55	disease	1	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.4	medium_impact	0.83	medium_impact	0.61	0.8	28.86	7.21	0.37	N	0.92	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13902	13902	C	A	MI.22591	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1566	522	F	L	ttC/ttA	3.61	1	0	probably_damaging	1	neutral	0.67	neutral	0.4	neutral	-2.8	deleterious	-5.13	medium_impact	2.23	0.54	damaging	0.14	damaging	4.80	24.80	deleterious	0.41	0.5	0.52	disease	0.74	disease	0.7	disease	0.55	disease	1	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.4	medium_impact	0.83	medium_impact	0.61	0.8	28.86	7.21	0.39	N	0.92	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13903	13903	T	G	MI.22592	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1567	523	S	A	Tcc/Gcc	-1.44	0	0	probably_damaging	1	neutral	0.55	neutral	0.79	neutral	-1.86	deleterious	-2.58	high_impact	3.61	0.72	neutral	0.23	damaging	3.80	23.40	deleterious	0.41	0.5	0.44	neutral	0.58	disease	0.7	disease	0.7	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.73	deleterious	-3.6	low_impact	0.28	medium_impact	2.1	high_impact	0.77	0.85	4.98	6.89	0.26	N	0.49	disease_causing	0.53	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13903	13903	T	A	MI.22593	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1567	523	S	T	Tcc/Acc	-1.44	0	0	probably_damaging	1	neutral	0.44	neutral	0.8	neutral	-1.74	neutral	-2.45	medium_impact	2.22	0.8	neutral	0.51	neutral	3.88	23.50	deleterious	0.32	0.5	0.58	disease	0.63	disease	0.46	neutral	0.48	neutral	0	1	deleterious	0.22	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.18	medium_impact	0.83	medium_impact	0.85	0.9	4.98	6.89	0.24	N	0.71	disease_causing	0.79	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13903	13903	T	C	MI.22594	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1567	523	S	P	Tcc/Ccc	-1.44	0	0	probably_damaging	1	neutral	0.22	neutral	0.72	deleterious	-4.25	deleterious	-4.35	medium_impact	2.71	0.64	neutral	0.2	damaging	4.11	23.70	deleterious	0.18	0.45	0.76	disease	0.83	disease	0.75	disease	0.79	disease	6	1	deleterious	0.11	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	-0.07	medium_impact	1.27	medium_impact	0.66	0.8	4.98	6.89	0.25	N	0.98	disease_causing	0.96	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13904	13904	C	T	MI.22595	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1568	523	S	F	tCc/tTc	5.44	0.99	0	probably_damaging	1	neutral	0.71	neutral	0.86	neutral	-1	deleterious	-5.04	low_impact	1.64	0.75	neutral	0.25	damaging	4.44	24.20	deleterious	0.28	0.45	0.46	neutral	0.84	disease	0.65	disease	0.56	disease	1	1	deleterious	0.36	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.45	medium_impact	0.3	medium_impact	0.44	0.8	4.98	6.89	0.39	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13904	13904	C	G	MI.22596	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1568	523	S	C	tCc/tGc	5.44	0.99	0	probably_damaging	1	neutral	0.18	neutral	0.72	deleterious	-4.16	deleterious	-4.31	high_impact	3.61	0.69	neutral	0.14	damaging	3.73	23.30	deleterious	0.26	0.45	0.77	disease	0.83	disease	0.69	disease	0.75	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	-0.13	medium_impact	2.1	high_impact	0.73	0.85	4.98	6.89	0.47	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13904	13904	C	A	MI.22597	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1568	523	S	Y	tCc/tAc	5.44	0.99	0	probably_damaging	1	neutral	1	neutral	0.73	deleterious	-3.32	deleterious	-5.09	medium_impact	3.06	0.73	neutral	0.15	damaging	4.26	23.90	deleterious	0.21	0.45	0.64	disease	0.86	disease	0.73	disease	0.79	disease	6	1	deleterious	0.5	deleterious	1	deleterious	0.82	deleterious	-3.6	low_impact	1.89	high_impact	1.59	medium_impact	0.74	0.85	4.98	6.89	0.41	N	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13906	13906	A	G	MI.22598	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1570	524	N	D	Aac/Gac	-9.46	0	0	possibly_damaging	0.85	neutral	0.24	neutral	0.89	neutral	-1.97	deleterious	-2.7	medium_impact	2.65	0.69	neutral	0.54	neutral	2.41	18.91	deleterious	0.62	0.65	0.44	neutral	0.7	disease	0.74	disease	0.72	disease	4	0.89	neutral	0.2	neutral	0	NA	0.57	deleterious	-1.46	low_impact	-0.04	medium_impact	1.22	medium_impact	0.72	0.85	8.79	11.75	0.35	N	0.58	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13906	13906	A	T	MI.22599	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1570	524	N	Y	Aac/Tac	-9.46	0	0	probably_damaging	0.97	neutral	1	neutral	0.87	neutral	-2.78	deleterious	-4.42	medium_impact	2.31	0.8	neutral	0.45	neutral	3.81	23.40	deleterious	0.37	0.5	0.36	neutral	0.83	disease	0.7	disease	0.75	disease	5	0.97	neutral	0.52	deleterious	1	deleterious	0.71	deleterious	-2.18	low_impact	1.89	high_impact	0.91	medium_impact	0.55	0.8	8.79	11.75	0.19	N	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8632	8632	T	C	MI.226	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	106	36	Y	H	Tat/Cat	-10.05	0	0	benign	0	neutral	0.46	neutral	4.41	neutral	0.72	neutral	1.15	neutral_impact	0.55	0.88	neutral	0.93	neutral	0.37	6.38	deleterious	0.71	0.75	0.62	disease	0.32	neutral	0.23	neutral	0.61	disease	2	0.54	neutral	0.73	deleterious	-6	neutral	0.19	neutral	2.09	high_impact	0.25	medium_impact	-0.63	medium_impact	0.41	0.9	29.2	23.72	0.36	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6085	6085	A	G	MI.2260	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	182	61	H	R	cAt/cGt	4.52	1	0	probably_damaging	1	deleterious	0	neutral	-1.17	deleterious	-12.45	deleterious	-5.1	high_impact	5.19	0.57	damaging	0.03	damaging	2.91	21.90	deleterious	0.27	0.55	0.88	disease	0.92	disease	0.77	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.39	0.9	2.92	6.76	0.56	P	0.85	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13906	13906	A	C	MI.22600	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1570	524	N	H	Aac/Cac	-9.46	0	0	probably_damaging	0.98	neutral	0.55	neutral	0.87	neutral	-2.71	deleterious	-3.08	medium_impact	3	0.72	neutral	0.52	neutral	3.19	22.70	deleterious	0.44	0.55	0.6	disease	0.76	disease	0.74	disease	0.75	disease	5	0.98	deleterious	0.29	neutral	1	deleterious	0.76	deleterious	-2.35	low_impact	0.28	medium_impact	1.54	medium_impact	0.66	0.8	8.79	11.75	0.25	N	0.38	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13907	13907	A	C	MI.22601	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1571	524	N	T	aAc/aCc	2.23	0	0	benign	0.2	neutral	0.44	neutral	1.01	neutral	0.13	neutral	-0.94	low_impact	1.17	0.86	neutral	0.97	neutral	0.34	6.06	deleterious	0.45	0.55	0.39	neutral	0.59	disease	0.39	neutral	0.47	neutral	1	0.47	neutral	0.62	deleterious	-6	neutral	0.19	neutral	-0.17	medium_impact	0.18	medium_impact	-0.13	medium_impact	0.62	0.8	8.79	11.75	0.34	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13907	13907	A	G	MI.22602	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1571	524	N	S	aAc/aGc	2.23	0	0	possibly_damaging	0.74	neutral	0.47	neutral	1.05	neutral	0.41	neutral	-1.82	low_impact	1.3	0.85	neutral	0.96	neutral	1.50	13.32	neutral	0.68	0.7	0.35	neutral	0.51	disease	0.41	neutral	0.45	neutral	1	0.73	neutral	0.37	neutral	-3	neutral	0.43	neutral	-1.18	low_impact	0.2	medium_impact	-0.02	medium_impact	0.41	0.8	8.79	11.75	0.33	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13907	13907	A	T	MI.22603	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1571	524	N	I	aAc/aTc	2.23	0	0	benign	0.17	neutral	0.42	neutral	0.91	neutral	-1.26	deleterious	-4.32	low_impact	1.7	0.86	neutral	0.95	neutral	2.22	17.65	deleterious	0.35	0.5	0.59	disease	0.84	disease	0.45	neutral	0.57	disease	1	0.5	neutral	0.63	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	0.16	medium_impact	0.35	medium_impact	0.44	0.8	8.79	11.75	0.34	N	0.16	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13908	13908	C	A	MI.22604	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1572	524	N	K	aaC/aaA	-1.21	0	0	possibly_damaging	0.88	neutral	0.36	neutral	0.92	neutral	-1.1	deleterious	-3.15	medium_impact	2.65	0.71	neutral	0.58	neutral	3.05	22.40	deleterious	0.62	0.65	0.35	neutral	0.78	disease	0.73	disease	0.72	disease	4	0.88	neutral	0.24	neutral	0	NA	0.59	deleterious	-1.57	low_impact	0.1	medium_impact	1.22	medium_impact	0.75	0.85	8.79	11.75	0.31	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13908	13908	C	G	MI.22605	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1572	524	N	K	aaC/aaG	-1.21	0	0	possibly_damaging	0.88	neutral	0.36	neutral	0.92	neutral	-1.1	deleterious	-3.15	medium_impact	2.65	0.71	neutral	0.58	neutral	2.53	19.66	deleterious	0.62	0.65	0.35	neutral	0.78	disease	0.73	disease	0.72	disease	4	0.88	neutral	0.24	neutral	0	NA	0.59	deleterious	-1.57	low_impact	0.1	medium_impact	1.22	medium_impact	0.75	0.85	8.79	11.75	0.32	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13909	13909	A	C	MI.22606	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1573	525	M	L	Ata/Cta	-4.87	0	0	probably_damaging	0.98	neutral	0.71	neutral	1.05	neutral	0.5	neutral	-0.86	neutral_impact	0.56	0.85	neutral	0.99	neutral	1.72	14.53	neutral	0.39	0.5	0.32	neutral	0.58	disease	0.4	neutral	0.46	neutral	1	0.98	deleterious	0.37	neutral	-2	neutral	0.63	deleterious	-2.35	low_impact	0.45	medium_impact	-0.69	medium_impact	0.56	0.8	14.93	12.75	0.23	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13909	13909	A	T	MI.22607	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1573	525	M	L	Ata/Tta	-4.87	0	0	probably_damaging	0.98	neutral	0.71	neutral	1.05	neutral	0.5	neutral	-0.86	neutral_impact	0.56	0.85	neutral	0.99	neutral	1.80	14.97	neutral	0.39	0.5	0.32	neutral	0.58	disease	0.4	neutral	0.46	neutral	1	0.98	deleterious	0.37	neutral	-2	neutral	0.63	deleterious	-2.35	low_impact	0.45	medium_impact	-0.69	medium_impact	0.56	0.8	14.93	12.75	0.24	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13909	13909	A	G	MI.22608	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1573	525	M	V	Ata/Gta	-4.87	0	0	probably_damaging	0.99	neutral	0.52	neutral	0.95	neutral	-0.68	neutral	-2.13	medium_impact	2.61	0.77	neutral	0.69	neutral	2.79	21.30	deleterious	0.45	0.55	0.48	neutral	0.76	disease	0.7	disease	0.75	disease	5	0.99	deleterious	0.27	neutral	1	deleterious	0.70	deleterious	-2.64	low_impact	0.25	medium_impact	1.18	medium_impact	0.57	0.8	14.93	12.75	0.24	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13910	13910	T	A	MI.22609	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1574	525	M	K	aTa/aAa	-4.19	0	0	probably_damaging	1	neutral	0.38	neutral	0.92	neutral	-1.28	deleterious	-3.47	medium_impact	2.15	0.74	neutral	0.63	neutral	4.16	23.80	deleterious	0.25	0.45	0.25	neutral	0.87	disease	0.75	disease	0.77	disease	5	1	deleterious	0.19	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.12	medium_impact	0.76	medium_impact	0.50	0.8	14.93	12.75	0.34	N	0.90	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6085	6085	A	T	MI.2261	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	182	61	H	L	cAt/cTt	4.52	1	0	probably_damaging	1	deleterious	0.01	neutral	-1.18	deleterious	-12.95	deleterious	-7.01	high_impact	5.19	0.63	neutral	0.03	damaging	3.76	23.40	deleterious	0.22	0.55	0.92	disease	0.92	disease	0.74	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-0.92	medium_impact	3.69	high_impact	0.33	0.9	2.92	6.76	0.54	P	0.92	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13910	13910	T	C	MI.22610	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1574	525	M	T	aTa/aCa	-4.19	0	0	probably_damaging	1	neutral	0.45	neutral	0.97	neutral	-0.43	deleterious	-3.04	low_impact	1.92	0.85	neutral	0.93	neutral	3.10	22.50	deleterious	0.37	0.5	0.47	neutral	0.76	disease	0.51	disease	0.54	disease	1	1	deleterious	0.23	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.18	medium_impact	0.55	medium_impact	0.32	0.8	14.93	12.75	0.27	N	0.63	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13911	13911	A	T	MI.22611	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1575	525	M	I	atA/atT	-0.06	0	0	probably_damaging	0.99	neutral	0.42	neutral	0.93	neutral	-1.01	neutral	-1.92	medium_impact	2.06	0.74	neutral	0.77	neutral	3.63	23.20	deleterious	0.47	0.55	0.64	disease	0.76	disease	0.68	disease	0.68	disease	4	0.99	deleterious	0.22	neutral	1	deleterious	0.77	deleterious	-2.64	low_impact	0.16	medium_impact	0.68	medium_impact	0.64	0.8	14.93	12.75	0.29	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13911	13911	A	C	MI.22612	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1575	525	M	I	atA/atC	-0.06	0	0	probably_damaging	0.99	neutral	0.42	neutral	0.93	neutral	-1.01	neutral	-1.92	medium_impact	2.06	0.74	neutral	0.77	neutral	3.56	23.10	deleterious	0.47	0.55	0.64	disease	0.76	disease	0.68	disease	0.68	disease	4	0.99	deleterious	0.22	neutral	1	deleterious	0.77	deleterious	-2.64	low_impact	0.16	medium_impact	0.68	medium_impact	0.64	0.8	14.93	12.75	0.3	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13912	13912	C	G	MI.22613	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1576	526	L	V	Ctc/Gtc	-3.5	0	0	probably_damaging	1	neutral	0.53	neutral	0.65	neutral	-2.39	deleterious	-2.68	medium_impact	3.17	0.71	neutral	0.38	neutral	3.60	23.20	deleterious	0.46	0.55	0.56	disease	0.65	disease	0.66	disease	0.61	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.26	medium_impact	1.69	medium_impact	0.68	0.85	18.74	7.03	0.22	N	0.81	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13912	13912	C	T	MI.22614	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1576	526	L	F	Ctc/Ttc	-3.5	0	0	probably_damaging	1	neutral	0.71	neutral	0.61	deleterious	-3.1	deleterious	-3.56	medium_impact	2.4	0.71	neutral	0.45	neutral	4.16	23.80	deleterious	0.38	0.5	0.82	disease	0.76	disease	0.59	disease	0.67	disease	3	1	deleterious	0.36	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.45	medium_impact	0.99	medium_impact	0.68	0.85	18.74	7.03	0.19	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13912	13912	C	A	MI.22615	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1576	526	L	I	Ctc/Atc	-3.5	0	0	probably_damaging	1	neutral	0.42	neutral	0.64	neutral	-2.55	neutral	-1.79	medium_impact	2.83	0.71	neutral	0.58	neutral	4.25	23.90	deleterious	0.36	0.5	0.73	disease	0.69	disease	0.63	disease	0.67	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.16	medium_impact	1.38	medium_impact	0.78	0.85	18.74	7.03	0.27	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13913	13913	T	G	MI.22616	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1577	526	L	R	cTc/cGc	-1.89	0	0	probably_damaging	1	neutral	0.41	neutral	0.57	deleterious	-4.37	deleterious	-5.37	high_impact	3.72	0.59	damaging	0.27	damaging	4.37	24.10	deleterious	0.2	0.45	0.32	neutral	0.88	disease	0.76	disease	0.77	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.15	medium_impact	2.2	high_impact	0.70	0.85	18.74	7.03	0.35	N	1.00	polymorphism	0.93	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13913	13913	T	A	MI.22617	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1577	526	L	H	cTc/cAc	-1.89	0	0	probably_damaging	1	neutral	0.56	neutral	0.56	deleterious	-5.06	deleterious	-6.26	high_impact	3.72	0.67	neutral	0.42	neutral	4.40	24.10	deleterious	0.22	0.45	0.76	disease	0.83	disease	0.74	disease	0.79	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.29	medium_impact	2.2	high_impact	0.62	0.8	18.74	7.03	0.3	N	0.97	polymorphism	0.96	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13913	13913	T	C	MI.22618	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1577	526	L	P	cTc/cCc	-1.89	0	0	probably_damaging	1	neutral	0.24	neutral	0.56	deleterious	-5.13	deleterious	-6.27	medium_impact	2.44	0.61	neutral	0.28	damaging	4.13	23.80	deleterious	0.15	0.4	0.7	disease	0.82	disease	0.72	disease	0.75	disease	5	1	deleterious	0.12	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	-0.04	medium_impact	1.03	medium_impact	0.49	0.8	18.74	7.03	0.24	N	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13915	13915	G	C	MI.22619	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1579	527	G	R	Gga/Cga	-0.52	0.04	0	probably_damaging	1	neutral	0.35	neutral	0.82	neutral	-2.84	deleterious	-7.17	high_impact	3.56	0.43	damaging	0.07	damaging	4.06	23.70	deleterious	0.25	0.45	0.62	disease	0.88	disease	0.73	disease	0.81	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	0.08	medium_impact	2.05	high_impact	0.81	0.85	28.86	7.22	0.4	N	1.00	disease_causing	0.64	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6085	6085	A	C	MI.2262	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	182	61	H	P	cAt/cCt	4.52	1	0	probably_damaging	1	deleterious	0	neutral	-1.16	deleterious	-10.44	deleterious	-6.38	high_impact	5.19	0.48	damaging	0.03	damaging	3.24	22.80	deleterious	0.21	0.55	0.91	disease	0.89	disease	0.82	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.33	0.9	2.92	6.76	0.54	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13915	13915	G	T	MI.22620	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1579	527	G	W	Gga/Tga	-0.52	0.04	0	probably_damaging	1	neutral	0.19	neutral	1.22	neutral	1.14	deleterious	-7.17	medium_impact	2.58	0.53	damaging	0.07	damaging	4.57	24.40	deleterious	0.22	0.45	0.45	neutral	0.85	disease	0.62	disease	0.57	disease	1	1	deleterious	0.1	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.12	medium_impact	1.15	medium_impact	0.44	0.8	28.86	7.22	0.27	N	1.00	disease_causing	0.75	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13916	13916	G	C	MI.22621	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1580	527	G	A	gGa/gCa	2.69	0.97	0	probably_damaging	1	neutral	0.51	neutral	0.89	neutral	-1.09	deleterious	-5.38	low_impact	1.7	0.6	damaging	0.28	damaging	3.31	22.90	deleterious	0.39	0.5	0.5	disease	0.36	neutral	0.29	neutral	0.19	neutral	6	1	deleterious	0.26	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.24	medium_impact	0.35	medium_impact	0.75	0.85	28.86	7.22	0.41	N	0.79	polymorphism	0.55	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13916	13916	G	T	MI.22622	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1580	527	G	V	gGa/gTa	2.69	0.97	0	probably_damaging	1	neutral	0.5	neutral	0.88	neutral	-1.18	deleterious	-8.06	medium_impact	3.21	0.45	damaging	0.08	damaging	4.00	23.60	deleterious	0.26	0.45	0.4	neutral	0.85	disease	0.65	disease	0.74	disease	5	1	deleterious	0.25	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.23	medium_impact	1.73	medium_impact	0.60	0.8	28.86	7.22	0.39	N	0.98	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13916	13916	G	A	MI.22623	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1580	527	G	E	gGa/gAa	2.69	0.97	0	probably_damaging	1	neutral	0.28	neutral	0.82	neutral	-2.67	deleterious	-7.17	high_impact	3.56	0.46	damaging	0.08	damaging	4.02	23.60	deleterious	0.25	0.45	0.78	disease	0.85	disease	0.73	disease	0.79	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.01	medium_impact	2.05	high_impact	0.72	0.85	28.86	7.22	0.42	N	1.00	disease_causing	0.68	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13918	13918	T	A	MI.22624	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1582	528	F	I	Ttc/Atc	-13.58	0	0	possibly_damaging	0.87	neutral	0.39	neutral	-0.27	deleterious	-6.98	deleterious	-4.33	medium_impact	2.64	0.69	neutral	0.61	neutral	4.62	24.50	deleterious	0.26	0.45	0.5	neutral	0.84	disease	0.7	disease	0.77	disease	5	0.87	neutral	0.26	neutral	0	NA	0.79	deleterious	-1.53	low_impact	0.13	medium_impact	1.21	medium_impact	0.66	0.8	7.13	10.57	0.31	N	0.67	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13918	13918	T	C	MI.22625	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1582	528	F	L	Ttc/Ctc	-13.58	0	0	possibly_damaging	0.62	neutral	0.66	neutral	-0.25	deleterious	-5.88	deleterious	-4.33	medium_impact	2.64	0.68	neutral	0.58	neutral	4.29	24.00	deleterious	0.32	0.5	0.37	neutral	0.81	disease	0.67	disease	0.68	disease	4	0.55	neutral	0.52	deleterious	0	NA	0.75	deleterious	-0.95	medium_impact	0.39	medium_impact	1.21	medium_impact	0.70	0.85	7.13	10.57	0.3	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13918	13918	T	G	MI.22626	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1582	528	F	V	Ttc/Gtc	-13.58	0	0	possibly_damaging	0.79	neutral	0.49	neutral	-0.26	deleterious	-6.83	deleterious	-4.7	medium_impact	2.64	0.65	neutral	0.59	neutral	4.31	24.00	deleterious	0.33	0.5	0.31	neutral	0.88	disease	0.71	disease	0.79	disease	6	0.77	neutral	0.35	neutral	0	NA	0.74	deleterious	-1.29	low_impact	0.22	medium_impact	1.21	medium_impact	0.59	0.8	7.13	10.57	0.32	N	0.75	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13919	13919	T	A	MI.22627	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1583	528	F	Y	tTc/tAc	7.27	0.95	0	benign	0.04	neutral	1	neutral	0	neutral	-2.76	neutral	0.99	neutral_impact	0.07	0.87	neutral	0.98	neutral	1.91	15.68	deleterious	0.4	0.5	0.22	neutral	0.22	neutral	0.3	neutral	0.36	neutral	3	0.04	neutral	0.98	deleterious	-6	neutral	0.68	deleterious	0.57	medium_impact	1.89	high_impact	-1.14	low_impact	0.66	0.8	7.13	10.57	0.48	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13919	13919	T	C	MI.22628	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1583	528	F	S	tTc/tCc	7.27	0.95	0	possibly_damaging	0.9	neutral	0.41	neutral	-0.27	deleterious	-7.3	deleterious	-5.59	medium_impact	3.19	0.75	neutral	0.82	neutral	4.48	24.20	deleterious	0.28	0.45	0.6	disease	0.85	disease	0.7	disease	0.76	disease	5	0.9	neutral	0.26	neutral	0	NA	0.82	deleterious	-1.65	low_impact	0.15	medium_impact	1.71	medium_impact	0.55	0.8	7.13	10.57	0.53	N	0.89	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13919	13919	T	G	MI.22629	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1583	528	F	C	tTc/tGc	7.27	0.95	0	probably_damaging	0.98	neutral	0.17	neutral	-0.28	deleterious	-8.92	deleterious	-5.59	medium_impact	3.19	0.61	neutral	0.46	neutral	4.28	24.00	deleterious	0.23	0.45	0.8	disease	0.9	disease	0.72	disease	0.81	disease	6	0.99	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-2.35	low_impact	-0.15	medium_impact	1.71	medium_impact	0.43	0.8	7.13	10.57	0.47	N	0.90	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6086	6086	T	A	MI.2263	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	183	61	H	Q	caT/caA	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-1.17	deleterious	-11.86	deleterious	-5.1	high_impact	4.84	0.61	neutral	0.03	damaging	3.64	23.20	deleterious	0.3	0.55	0.83	disease	0.84	disease	0.72	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.40	0.9	2.92	6.76	0.62	P	0.83	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13920	13920	C	A	MI.22630	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1584	528	F	L	ttC/ttA	-0.29	0	0	possibly_damaging	0.62	neutral	0.66	neutral	-0.25	deleterious	-5.88	deleterious	-4.33	medium_impact	2.64	0.68	neutral	0.58	neutral	4.75	24.70	deleterious	0.32	0.5	0.37	neutral	0.81	disease	0.67	disease	0.68	disease	4	0.55	neutral	0.52	deleterious	0	NA	0.75	deleterious	-0.95	medium_impact	0.39	medium_impact	1.21	medium_impact	0.70	0.85	7.13	10.57	0.28	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13920	13920	C	G	MI.22631	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1584	528	F	L	ttC/ttG	-0.29	0	0	possibly_damaging	0.62	neutral	0.66	neutral	-0.25	deleterious	-5.88	deleterious	-4.33	medium_impact	2.64	0.68	neutral	0.58	neutral	4.52	24.30	deleterious	0.32	0.5	0.37	neutral	0.81	disease	0.67	disease	0.68	disease	4	0.55	neutral	0.52	deleterious	0	NA	0.75	deleterious	-0.95	medium_impact	0.39	medium_impact	1.21	medium_impact	0.70	0.85	7.13	10.57	0.28	N	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13921	13921	T	A	MI.22632	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1585	529	Y	N	Tac/Aac	-0.98	0	0	probably_damaging	0.98	neutral	0.3	neutral	0.89	deleterious	-3.48	deleterious	-6.04	medium_impact	2.13	0.74	neutral	0.76	neutral	4.13	23.80	deleterious	0.27	0.45	0.74	disease	0.81	disease	0.66	disease	0.75	disease	5	0.98	neutral	0.16	neutral	1	deleterious	0.84	deleterious	-2.35	low_impact	0.03	medium_impact	0.74	medium_impact	0.44	0.8	2.65	8.76	0.27	N	0.75	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13921	13921	T	G	MI.22633	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1585	529	Y	D	Tac/Gac	-0.98	0	0	probably_damaging	0.98	neutral	0.19	neutral	0.89	deleterious	-4.32	deleterious	-6.4	medium_impact	2.48	0.65	neutral	0.41	neutral	4.04	23.70	deleterious	0.21	0.45	0.81	disease	0.84	disease	0.72	disease	0.81	disease	6	0.98	deleterious	0.11	neutral	1	deleterious	0.86	deleterious	-2.35	low_impact	-0.12	medium_impact	1.06	medium_impact	0.39	0.8	2.65	8.76	0.26	N	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13921	13921	T	C	MI.22634	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1585	529	Y	H	Tac/Cac	-0.98	0	0	probably_damaging	0.98	neutral	0.5	neutral	0.89	deleterious	-3.47	deleterious	-3.52	medium_impact	2.48	0.75	neutral	0.51	neutral	3.69	23.30	deleterious	0.32	0.5	0.78	disease	0.66	disease	0.65	disease	0.72	disease	4	0.97	neutral	0.26	neutral	1	deleterious	0.83	deleterious	-2.35	low_impact	0.23	medium_impact	1.06	medium_impact	0.59	0.8	2.65	8.76	0.24	N	0.37	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13922	13922	A	T	MI.22635	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1586	529	Y	F	tAc/tTc	3.61	0.28	0	benign	0.04	neutral	0.82	neutral	1.25	neutral	1.73	neutral	0.49	neutral_impact	-1.19	0.84	neutral	0.98	neutral	1.39	12.76	neutral	0.41	0.5	0.24	neutral	0.1	neutral	0.3	neutral	0.23	neutral	5	0.11	neutral	0.89	deleterious	-6	neutral	0.66	deleterious	0.57	medium_impact	0.6	medium_impact	-2.29	low_impact	0.59	0.8	2.65	8.76	0.38	N	0.11	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13922	13922	A	G	MI.22636	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1586	529	Y	C	tAc/tGc	3.61	0.28	0	probably_damaging	0.98	neutral	0.16	neutral	0.89	deleterious	-3.53	deleterious	-5.61	medium_impact	2.13	0.61	neutral	0.48	neutral	4.21	23.90	deleterious	0.25	0.45	0.77	disease	0.85	disease	0.69	disease	0.8	disease	6	0.99	deleterious	0.09	neutral	1	deleterious	0.83	deleterious	-2.35	low_impact	-0.17	medium_impact	0.74	medium_impact	0.28	0.8	2.65	8.76	0.3	N	0.77	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13922	13922	A	C	MI.22637	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1586	529	Y	S	tAc/tCc	3.61	0.28	0	probably_damaging	0.92	neutral	0.47	neutral	0.9	neutral	-2.35	deleterious	-5.54	low_impact	1.78	0.65	neutral	0.58	neutral	4.35	24.10	deleterious	0.2	0.45	0.51	disease	0.73	disease	0.63	disease	0.72	disease	4	0.92	neutral	0.28	neutral	-2	neutral	0.79	deleterious	-1.75	low_impact	0.2	medium_impact	0.42	medium_impact	0.54	0.8	2.65	8.76	0.28	N	0.74	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13924	13924	C	A	MI.22638	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1588	530	P	T	Cct/Act	-3.27	0	0	benign	0.12	neutral	0.46	neutral	0.68	neutral	-2.36	deleterious	-5.47	low_impact	1.1	0.85	neutral	0.81	neutral	2.79	21.30	deleterious	0.33	0.5	0.51	disease	0.73	disease	0.35	neutral	0.54	disease	1	0.46	neutral	0.67	deleterious	-6	neutral	0.76	deleterious	0.08	medium_impact	0.19	medium_impact	-0.2	medium_impact	0.79	0.85	21.23	16.42	0.3	N	0.52	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13924	13924	C	T	MI.22639	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1588	530	P	S	Cct/Tct	-3.27	0	0	benign	0.12	neutral	0.51	neutral	0.69	neutral	-2.23	deleterious	-5.5	low_impact	1.03	0.86	neutral	0.73	neutral	2.90	21.90	deleterious	0.37	0.5	0.42	neutral	0.75	disease	0.35	neutral	0.54	disease	1	0.4	neutral	0.7	deleterious	-6	neutral	0.77	deleterious	0.08	medium_impact	0.24	medium_impact	-0.26	medium_impact	0.42	0.8	21.23	16.42	0.25	N	0.36	polymorphism	1	0.10	rs200713907	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6086	6086	T	G	MI.2264	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	183	61	H	Q	caT/caG	7.07	1	0	probably_damaging	1	deleterious	0	neutral	-1.17	deleterious	-11.86	deleterious	-5.1	high_impact	4.84	0.61	neutral	0.03	damaging	3.44	23.00	deleterious	0.3	0.55	0.83	disease	0.84	disease	0.72	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.40	0.9	2.92	6.76	0.61	P	0.83	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13924	13924	C	G	MI.22640	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1588	530	P	A	Cct/Gct	-3.27	0	0	possibly_damaging	0.62	neutral	0.59	neutral	0.67	neutral	-2.49	deleterious	-5.8	medium_impact	3.1	0.73	neutral	0.49	neutral	3.22	22.70	deleterious	0.27	0.45	0.43	neutral	0.64	disease	0.61	disease	0.67	disease	3	0.57	neutral	0.49	deleterious	0	NA	0.74	deleterious	-0.95	medium_impact	0.32	medium_impact	1.63	medium_impact	0.85	0.9	21.23	16.42	0.27	N	0.63	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13925	13925	C	G	MI.22641	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1589	530	P	R	cCt/cGt	1.31	0.22	0	probably_damaging	0.94	neutral	0.41	neutral	0.65	neutral	-2.98	deleterious	-6.77	medium_impact	3.1	0.72	neutral	0.34	neutral	3.76	23.30	deleterious	0.22	0.45	0.43	neutral	0.89	disease	0.73	disease	0.8	disease	6	0.93	neutral	0.24	neutral	1	deleterious	0.80	deleterious	-1.88	low_impact	0.15	medium_impact	1.63	medium_impact	0.70	0.85	21.23	16.42	0.26	N	0.94	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13925	13925	C	A	MI.22642	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1589	530	P	H	cCt/cAt	1.31	0.22	0	probably_damaging	0.98	neutral	0.55	neutral	0.62	deleterious	-4.07	deleterious	-6.84	medium_impact	2.76	0.74	neutral	0.38	neutral	4.10	23.70	deleterious	0.23	0.45	0.65	disease	0.83	disease	0.72	disease	0.77	disease	5	0.98	deleterious	0.29	neutral	1	deleterious	0.82	deleterious	-2.35	low_impact	0.28	medium_impact	1.32	medium_impact	0.75	0.85	21.23	16.42	0.22	N	0.91	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13925	13925	C	T	MI.22643	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1589	530	P	L	cCt/cTt	1.31	0.22	0	possibly_damaging	0.73	neutral	0.69	neutral	0.65	neutral	-2.89	deleterious	-7.6	medium_impact	3.1	0.8	neutral	0.4	neutral	4.45	24.20	deleterious	0.35	0.5	0.55	disease	0.87	disease	0.6	disease	0.75	disease	5	0.67	neutral	0.48	deleterious	0	NA	0.80	deleterious	-1.16	low_impact	0.42	medium_impact	1.63	medium_impact	0.80	0.85	21.23	16.42	0.23	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13927	13927	A	G	MI.22644	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1591	531	S	G	Agc/Ggc	-10.37	0	0	benign	0.11	neutral	0.34	neutral	0.9	neutral	-2.04	neutral	-2.42	low_impact	1.76	0.81	neutral	0.72	neutral	1.89	15.52	deleterious	0.38	0.5	0.54	disease	0.3	neutral	0.36	neutral	0.43	neutral	2	0.61	neutral	0.62	deleterious	-6	neutral	0.32	neutral	0.12	medium_impact	0.07	medium_impact	0.41	medium_impact	0.70	0.85	28.52	16.4	0.37	N	0.26	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13927	13927	A	T	MI.22645	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1591	531	S	C	Agc/Tgc	-10.37	0	0	possibly_damaging	0.76	neutral	0.17	neutral	0.87	deleterious	-3.83	neutral	-1.78	low_impact	1.76	0.72	neutral	0.4	neutral	3.52	23.10	deleterious	0.3	0.45	0.86	disease	0.59	disease	0.37	neutral	0.56	disease	1	0.88	neutral	0.21	neutral	-3	neutral	0.72	deleterious	-1.22	low_impact	-0.15	medium_impact	0.41	medium_impact	0.65	0.8	28.52	16.4	0.3	N	0.39	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13927	13927	A	C	MI.22646	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1591	531	S	R	Agc/Cgc	-10.37	0	0	benign	0.17	neutral	0.35	neutral	0.92	neutral	-1.29	neutral	-1.86	low_impact	1.42	0.81	neutral	0.64	neutral	2.28	18.00	deleterious	0.2	0.45	0.45	neutral	0.65	disease	0.49	neutral	0.49	neutral	0	0.58	neutral	0.59	deleterious	-6	neutral	0.51	deleterious	-0.09	medium_impact	0.08	medium_impact	0.09	medium_impact	0.73	0.85	28.52	16.4	0.31	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13928	13928	G	A	MI.22647	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1592	531	S	N	aGc/aAc	-4.19	0	0.35	benign	0	neutral	0.33	neutral	0.99	neutral	-0.12	neutral	-1.1	neutral_impact	0.26	0.82	neutral	0.85	neutral	0.62	8.28	deleterious	0.57	0.65	0.45	neutral	0.31	neutral	0.4	neutral	0.45	neutral	1	0.67	neutral	0.67	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.06	medium_impact	-0.97	medium_impact	0.68	0.85	28.52	16.4	0.36	N	0.00	polymorphism	1	0.02	rs28359184	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13928	13928	G	T	MI.22648	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1592	531	S	I	aGc/aTc	-4.19	0	0.35	benign	0.01	neutral	0.4	neutral	0.94	neutral	-0.92	neutral	-1.19	neutral_impact	-0.03	0.88	neutral	1	neutral	2.71	20.90	deleterious	0.3	0.45	0.62	disease	0.49	neutral	0.25	neutral	0.51	disease	0	0.59	neutral	0.7	deleterious	-6	neutral	0.63	deleterious	1.15	medium_impact	0.14	medium_impact	-1.23	low_impact	0.78	0.85	28.52	16.4	0.32	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13928	13928	G	C	MI.22649	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1592	531	S	T	aGc/aCc	-4.19	0	0.35	benign	0.01	neutral	0.4	neutral	0.96	neutral	-0.45	neutral	1.36	neutral_impact	-0.7	0.92	neutral	0.99	neutral	-0.98	0.02	neutral	0.32	0.5	0.28	neutral	0.09	neutral	0.13	neutral	0.26	neutral	5	0.59	neutral	0.7	deleterious	-6	neutral	0.32	neutral	1.15	medium_impact	0.14	medium_impact	-1.84	low_impact	0.70	0.85	28.52	16.4	0.46	N	0.00	polymorphism	1	0.00	rs28359184	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6087	6087	G	A	MI.2265	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	184	62	A	T	Gca/Aca	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.9	neutral	-2.64	neutral	-2.46	high_impact	4.99	0.63	neutral	0.05	damaging	4.12	23.80	deleterious	0.34	0.55	0.62	disease	0.86	disease	0.56	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.71	0.9	2.53	6.59	0.66	P	0.20	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13930	13930	A	C	MI.22650	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1594	532	I	L	Atc/Ctc	-9	0	0	benign	0.13	neutral	0.67	neutral	1.13	neutral	0.45	neutral	-1	neutral_impact	0.56	0.76	neutral	0.95	neutral	0.81	9.54	deleterious	0.47	0.55	0.33	neutral	0.34	neutral	0.28	neutral	0.47	neutral	1	0.22	neutral	0.77	deleterious	-6	neutral	0.24	neutral	0.04	medium_impact	0.4	medium_impact	-0.69	medium_impact	0.70	0.85	17.41	14.16	0.35	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13930	13930	A	G	MI.22651	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1594	532	I	V	Atc/Gtc	-9	0	0	benign	0.13	neutral	0.5	neutral	0.76	neutral	-1.23	neutral	-0.3	low_impact	1.52	0.78	neutral	0.98	neutral	0.18	4.42	deleterious	0.67	0.7	0.39	neutral	0.25	neutral	0.35	neutral	0.44	neutral	1	0.41	neutral	0.69	deleterious	-6	neutral	0.22	neutral	0.04	medium_impact	0.23	medium_impact	0.19	medium_impact	0.47	0.8	17.41	14.16	0.37	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13930	13930	A	T	MI.22652	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1594	532	I	F	Atc/Ttc	-9	0	0	possibly_damaging	0.73	neutral	0.72	neutral	0.61	deleterious	-3.37	deleterious	-2.5	medium_impact	3.13	0.79	neutral	0.54	neutral	3.72	23.30	deleterious	0.45	0.55	0.43	neutral	0.74	disease	0.54	disease	0.63	disease	3	0.68	neutral	0.5	deleterious	0	NA	0.64	deleterious	-1.16	low_impact	0.46	medium_impact	1.66	medium_impact	0.68	0.85	17.41	14.16	0.21	N	0.46	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13931	13931	T	G	MI.22653	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1595	532	I	S	aTc/aGc	-0.52	0	0	benign	0.27	neutral	0.42	neutral	0.58	deleterious	-4.31	deleterious	-2.97	medium_impact	3.13	0.74	neutral	0.42	neutral	2.75	21.10	deleterious	0.37	0.5	0.7	disease	0.81	disease	0.6	disease	0.74	disease	5	0.49	neutral	0.58	deleterious	-3	neutral	0.54	deleterious	-0.34	medium_impact	0.16	medium_impact	1.66	medium_impact	0.50	0.8	17.41	14.16	0.27	N	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13931	13931	T	A	MI.22654	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1595	532	I	N	aTc/aAc	-0.52	0	0	possibly_damaging	0.46	neutral	0.33	neutral	0.57	deleterious	-5.5	deleterious	-3.86	medium_impact	3.13	0.7	neutral	0.36	neutral	4.25	23.90	deleterious	0.34	0.5	0.82	disease	0.82	disease	0.63	disease	0.77	disease	5	0.63	neutral	0.44	neutral	0	NA	0.73	deleterious	-0.68	medium_impact	0.06	medium_impact	1.66	medium_impact	0.48	0.8	17.41	14.16	0.27	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13931	13931	T	C	MI.22655	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1595	532	I	T	aTc/aCc	-0.52	0	0	benign	0	neutral	0.4	neutral	0.62	deleterious	-3.01	neutral	-1.23	low_impact	0.81	0.86	neutral	0.99	neutral	0.12	3.81	deleterious	0.41	0.5	0.66	disease	0.49	neutral	0.36	neutral	0.56	disease	1	0.6	neutral	0.7	deleterious	-6	neutral	0.23	neutral	2.1	high_impact	0.14	medium_impact	-0.46	medium_impact	0.50	0.8	17.41	14.16	0.35	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13932	13932	C	A	MI.22656	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1596	532	I	M	atC/atA	1.08	0	0	possibly_damaging	0.86	neutral	0.25	neutral	0.62	neutral	-2.94	neutral	-1.63	low_impact	1.89	0.73	neutral	0.68	neutral	3.81	23.40	deleterious	0.53	0.6	0.71	disease	0.5	disease	0.36	neutral	0.53	disease	1	0.9	neutral	0.2	neutral	-3	neutral	0.71	deleterious	-1.5	low_impact	-0.03	medium_impact	0.52	medium_impact	0.76	0.85	17.41	14.16	0.37	N	0.67	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13932	13932	C	G	MI.22657	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1596	532	I	M	atC/atG	1.08	0	0	possibly_damaging	0.86	neutral	0.25	neutral	0.62	neutral	-2.94	neutral	-1.63	low_impact	1.89	0.73	neutral	0.68	neutral	3.36	22.90	deleterious	0.53	0.6	0.71	disease	0.5	disease	0.36	neutral	0.53	disease	1	0.9	neutral	0.2	neutral	-3	neutral	0.71	deleterious	-1.5	low_impact	-0.03	medium_impact	0.52	medium_impact	0.76	0.85	17.41	14.16	0.37	N	0.67	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13933	13933	A	G	MI.22658	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1597	533	T	A	Aca/Gca	-4.64	0	0.01	benign	0.02	neutral	0.51	neutral	0.93	neutral	-0.75	neutral	-0.48	low_impact	1.36	0.9	neutral	0.9	neutral	0.64	8.42	deleterious	0.49	0.55	0.39	neutral	0.27	neutral	0.34	neutral	0.45	neutral	1	0.47	neutral	0.75	deleterious	-6	neutral	0.19	neutral	0.86	medium_impact	0.24	medium_impact	0.04	medium_impact	0.62	0.8	27.69	17.48	0.31	N	0.21	polymorphism	1	0.01	rs879235634	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13933	13933	A	T	MI.22659	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1597	533	T	S	Aca/Tca	-4.64	0	0.01	benign	0.25	neutral	0.43	neutral	1.19	neutral	1.19	neutral	-0.77	low_impact	1.76	0.82	neutral	0.71	neutral	1.66	14.17	neutral	0.45	0.55	0.33	neutral	0.3	neutral	0.57	disease	0.49	neutral	0	0.48	neutral	0.59	deleterious	-6	neutral	0.32	neutral	-0.29	medium_impact	0.17	medium_impact	0.41	medium_impact	0.81	0.85	27.69	17.48	0.34	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6087	6087	G	T	MI.2266	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	184	62	A	S	Gca/Tca	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-2.1	neutral	-1.78	high_impact	4.64	0.63	neutral	0.04	damaging	3.57	23.10	deleterious	0.3	0.55	0.54	disease	0.86	disease	0.45	neutral	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.19	high_impact	0.75	0.9	2.53	6.59	0.45	N	0.64	disease_causing	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13933	13933	A	C	MI.22660	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1597	533	T	P	Aca/Cca	-4.64	0	0.01	possibly_damaging	0.72	neutral	0.23	neutral	0.85	deleterious	-3.35	neutral	-1.89	low_impact	1.22	0.69	neutral	0.65	neutral	3.23	22.80	deleterious	0.17	0.45	0.77	disease	0.71	disease	0.69	disease	0.64	disease	3	0.83	neutral	0.26	neutral	-3	neutral	0.67	deleterious	-1.14	low_impact	-0.06	medium_impact	-0.09	medium_impact	0.69	0.85	27.69	17.48	0.29	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13934	13934	C	A	MI.22661	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1598	533	T	K	aCa/aAa	0.4	0	0.01	possibly_damaging	0.44	neutral	0.32	neutral	0.87	neutral	-2.41	neutral	-1.44	medium_impact	2.11	0.77	neutral	0.53	neutral	2.79	21.30	deleterious	0.22	0.45	0.58	disease	0.64	disease	0.69	disease	0.74	disease	5	0.64	neutral	0.44	neutral	0	NA	0.47	deleterious	-0.65	medium_impact	0.05	medium_impact	0.73	medium_impact	0.74	0.85	27.69	17.48	0.28	N	0.28	polymorphism	1	0.03	rs193302971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13934	13934	C	T	MI.22662	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1598	533	T	M	aCa/aTa	0.4	0	0.01	benign	0.08	neutral	0.26	neutral	0.9	neutral	-1.38	neutral	2.14	low_impact	0.81	0.88	neutral	0.99	neutral	0.07	3.29	deleterious	0.37	0.5	0.32	neutral	0.15	neutral	0.27	neutral	0.29	neutral	4	0.71	neutral	0.59	deleterious	-6	neutral	0.12	neutral	0.26	medium_impact	-0.02	medium_impact	-0.46	medium_impact	0.76	0.85	27.69	17.48	0.38	N	0.00	polymorphism	1	0.01	rs193302971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13936	13936	C	A	MI.22663	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1600	534	H	N	Cac/Aac	-12.44	0	0	probably_damaging	1	neutral	0.31	neutral	0.67	neutral	-2.83	deleterious	-6.27	high_impact	3.56	0.52	damaging	0.14	damaging	4.12	23.80	deleterious	0.42	0.55	0.41	neutral	0.79	disease	0.77	disease	0.74	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.04	medium_impact	2.05	high_impact	0.62	0.8	27.36	7.18	0.36	N	0.97	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13936	13936	C	T	MI.22664	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1600	534	H	Y	Cac/Tac	-12.44	0	0	probably_damaging	1	neutral	1	neutral	0.62	deleterious	-4.93	deleterious	-5.37	high_impact	3.9	0.54	damaging	0.11	damaging	3.94	23.50	deleterious	0.45	0.55	0.82	disease	0.83	disease	0.79	disease	0.85	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.6	low_impact	1.89	high_impact	2.36	high_impact	0.49	0.8	27.36	7.18	0.28	N	1.00	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13936	13936	C	G	MI.22665	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1600	534	H	D	Cac/Gac	-12.44	0	0	probably_damaging	1	neutral	0.2	neutral	0.66	deleterious	-3.15	deleterious	-8.06	high_impact	3.9	0.55	damaging	0.13	damaging	4.05	23.70	deleterious	0.2	0.45	0.43	neutral	0.83	disease	0.84	disease	0.83	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	-0.1	medium_impact	2.36	high_impact	0.54	0.8	27.36	7.18	0.41	N	0.97	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13937	13937	A	G	MI.22666	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1601	534	H	R	cAc/cGc	5.44	1	0	probably_damaging	1	neutral	0.35	neutral	0.65	deleterious	-3.25	deleterious	-7.16	high_impact	3.9	0.55	damaging	0.13	damaging	3.05	22.40	deleterious	0.4	0.5	0.42	neutral	0.86	disease	0.81	disease	0.82	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.08	medium_impact	2.36	high_impact	0.49	0.8	27.36	7.18	0.52	P	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13937	13937	A	T	MI.22667	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1601	534	H	L	cAc/cTc	5.44	1	0	probably_damaging	1	neutral	0.65	neutral	0.64	deleterious	-3.65	deleterious	-9.85	high_impact	3.9	0.46	damaging	0.11	damaging	3.87	23.50	deleterious	0.24	0.45	0.57	disease	0.9	disease	0.78	disease	0.82	disease	6	1	deleterious	0.33	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.38	medium_impact	2.36	high_impact	0.37	0.8	27.36	7.18	0.61	P	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13937	13937	A	C	MI.22668	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1601	534	H	P	cAc/cCc	5.44	1	0	probably_damaging	1	neutral	0.2	neutral	0.63	deleterious	-4.39	deleterious	-8.96	medium_impact	3.36	0.49	damaging	0.14	damaging	3.28	22.80	deleterious	0.23	0.45	0.7	disease	0.86	disease	0.84	disease	0.85	disease	7	1	deleterious	0.1	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.1	medium_impact	1.87	medium_impact	0.43	0.8	27.36	7.18	0.53	P	0.97	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13938	13938	C	A	MI.22669	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1602	534	H	Q	caC/caA	6.59	1	0	probably_damaging	1	neutral	0.29	neutral	0.66	deleterious	-3.09	deleterious	-7.16	high_impact	3.56	0.49	damaging	0.15	damaging	4.05	23.70	deleterious	0.39	0.5	0.51	disease	0.77	disease	0.78	disease	0.75	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.02	medium_impact	2.05	high_impact	0.61	0.8	27.36	7.18	0.56	P	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6087	6087	G	C	MI.2267	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	184	62	A	P	Gca/Cca	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-3.83	deleterious	-3.06	high_impact	4.99	0.54	damaging	0.04	damaging	3.72	23.30	deleterious	0.13	0.55	0.28	neutral	0.88	disease	0.68	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.74	0.9	2.53	6.59	0.61	P	0.85	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13938	13938	C	G	MI.22670	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1602	534	H	Q	caC/caG	6.59	1	0	probably_damaging	1	neutral	0.29	neutral	0.66	deleterious	-3.09	deleterious	-7.16	high_impact	3.56	0.49	damaging	0.15	damaging	3.75	23.30	deleterious	0.39	0.5	0.51	disease	0.77	disease	0.78	disease	0.75	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	0.02	medium_impact	2.05	high_impact	0.61	0.8	27.36	7.18	0.56	P	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13939	13939	C	A	MI.22671	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1603	535	R	S	Cgc/Agc	-0.75	0.05	0	probably_damaging	1	neutral	0.41	neutral	0.86	neutral	-1.16	deleterious	-5.37	high_impact	3.88	0.44	damaging	0.08	damaging	4.87	24.90	deleterious	0.33	0.5	0.61	disease	0.81	disease	0.73	disease	0.74	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.15	medium_impact	2.34	high_impact	0.45	0.8	28.52	7.13	0.43	N	0.82	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13939	13939	C	T	MI.22672	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1603	535	R	C	Cgc/Tgc	-0.75	0.05	0	probably_damaging	1	neutral	0.17	neutral	0.74	deleterious	-5.07	deleterious	-7.15	high_impact	3.88	0.49	damaging	0.05	damaging	5.16	25.40	deleterious	0.35	0.5	0.94	disease	0.86	disease	0.75	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.15	medium_impact	2.34	high_impact	0.75	0.85	28.52	7.13	0.35	N	1.00	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13939	13939	C	G	MI.22673	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1603	535	R	G	Cgc/Ggc	-0.75	0.05	0	probably_damaging	1	neutral	0.34	neutral	0.77	neutral	-2.74	deleterious	-6.26	high_impact	3.88	0.5	damaging	0.12	damaging	4.35	24.10	deleterious	0.26	0.45	0.64	disease	0.78	disease	0.73	disease	0.75	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.07	medium_impact	2.34	high_impact	0.40	0.8	28.52	7.13	0.35	N	0.97	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13940	13940	G	T	MI.22674	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1604	535	R	L	cGc/cTc	2.69	0.98	0	probably_damaging	1	neutral	0.67	neutral	0.81	neutral	-1.77	deleterious	-6.26	high_impact	3.54	0.43	damaging	0.05	damaging	4.50	24.30	deleterious	0.42	0.55	0.67	disease	0.92	disease	0.71	disease	0.8	disease	6	1	deleterious	0.34	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	0.4	medium_impact	2.03	high_impact	0.29	0.8	28.52	7.13	0.54	P	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13940	13940	G	C	MI.22675	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1604	535	R	P	cGc/cCc	2.69	0.98	0	probably_damaging	1	neutral	0.21	neutral	0.76	deleterious	-3.18	deleterious	-6.26	high_impact	3.54	0.45	damaging	0.06	damaging	4.44	24.20	deleterious	0.16	0.45	0.74	disease	0.87	disease	0.83	disease	0.85	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.09	medium_impact	2.03	high_impact	0.32	0.8	28.52	7.13	0.52	P	0.99	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13940	13940	G	A	MI.22676	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1604	535	R	H	cGc/cAc	2.69	0.98	0	probably_damaging	1	neutral	0.54	neutral	0.77	neutral	-2.81	deleterious	-4.48	medium_impact	2.84	0.53	damaging	0.06	damaging	4.56	24.40	deleterious	0.38	0.5	0.79	disease	0.79	disease	0.58	disease	0.61	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.27	medium_impact	1.39	medium_impact	0.86	0.9	28.52	7.13	0.38	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13942	13942	A	C	MI.22677	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1606	536	T	P	Aca/Cca	-8.31	0	0.02	benign	0.41	neutral	0.23	neutral	0.99	neutral	-0.28	neutral	-2.2	neutral_impact	0.7	0.71	neutral	0.77	neutral	3.31	22.90	deleterious	0.16	0.45	0.63	disease	0.68	disease	0.58	disease	0.58	disease	2	0.73	neutral	0.41	neutral	-6	neutral	0.68	deleterious	-0.6	medium_impact	-0.06	medium_impact	-0.56	medium_impact	0.66	0.8	23.55	18.53	0.31	N	0.33	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13942	13942	A	T	MI.22678	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1606	536	T	S	Aca/Tca	-8.31	0	0.02	benign	0.01	neutral	0.45	neutral	1.03	neutral	0.51	neutral	-0.67	neutral_impact	-0.04	0.88	neutral	0.97	neutral	0.38	6.44	deleterious	0.47	0.55	0.51	disease	0.2	neutral	0.17	neutral	0.29	neutral	4	0.54	neutral	0.72	deleterious	-6	neutral	0.17	neutral	1.15	medium_impact	0.18	medium_impact	-1.24	low_impact	0.68	0.85	23.55	18.53	0.46	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13942	13942	A	G	MI.22679	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1606	536	T	A	Aca/Gca	-8.31	0	0.02	benign	0.04	neutral	0.51	neutral	1.02	neutral	0.33	neutral	-0.58	neutral_impact	0.12	0.78	neutral	0.88	neutral	0.66	8.57	deleterious	0.63	0.7	0.45	neutral	0.19	neutral	0.32	neutral	0.38	neutral	2	0.44	neutral	0.74	deleterious	-6	neutral	0.25	neutral	0.57	medium_impact	0.24	medium_impact	-1.09	low_impact	0.42	0.8	23.55	18.53	0.26	N	0.14	polymorphism	1	0.01	rs200657506	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6088	6088	C	G	MI.2268	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	185	62	A	G	gCa/gGa	5.22	1	0	probably_damaging	0.99	neutral	0.11	neutral	3.11	neutral	2.96	neutral	-2.11	low_impact	1.88	0.6	neutral	0.06	damaging	3.76	23.30	deleterious	0.25	0.55	0.18	neutral	0.71	disease	0.32	neutral	0.5	neutral	0	1	deleterious	0.06	neutral	-2	neutral	0.73	deleterious	-2.64	low_impact	-0.31	medium_impact	0.64	medium_impact	0.74	0.9	2.53	6.59	0.46	P	0.56	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13943	13943	C	T	MI.22680	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1607	536	T	M	aCa/aTa	-8.31	0	0	benign	0.01	neutral	0.24	neutral	1.02	neutral	0.39	neutral	1.01	neutral_impact	-0.3	0.86	neutral	0.85	neutral	1.00	10.66	neutral	0.4	0.5	0.53	disease	0.25	neutral	0.19	neutral	0.41	neutral	2	0.75	neutral	0.62	deleterious	-6	neutral	0.21	neutral	1.15	medium_impact	-0.04	medium_impact	-1.48	low_impact	0.79	0.85	23.55	18.53	0.43	N	0.01	polymorphism	1	0.01	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13943	13943	C	A	MI.22681	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1607	536	T	K	aCa/aAa	-8.31	0	0	benign	0.11	neutral	0.31	neutral	0.97	neutral	-0.69	neutral	-1.49	neutral_impact	0.24	0.77	neutral	0.7	neutral	2.85	21.60	deleterious	0.31	0.5	0.75	disease	0.51	disease	0.56	disease	0.66	disease	3	0.64	neutral	0.6	deleterious	-6	neutral	0.53	deleterious	0.12	medium_impact	0.04	medium_impact	-0.98	medium_impact	0.74	0.85	23.55	18.53	0.28	N	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13945	13945	A	C	MI.22682	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1609	537	I	L	Atc/Ctc	-4.87	0	0	benign	0.17	neutral	0.68	neutral	1.02	neutral	0.12	neutral	0.2	neutral_impact	-0.25	0.79	neutral	0.98	neutral	-0.23	0.95	neutral	0.47	0.55	0.37	neutral	0.16	neutral	0.14	neutral	0.27	neutral	5	0.2	neutral	0.76	deleterious	-6	neutral	0.21	neutral	-0.09	medium_impact	0.41	medium_impact	-1.43	low_impact	0.73	0.85	31.51	21.31	0.39	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13945	13945	A	G	MI.22683	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1609	537	I	V	Atc/Gtc	-4.87	0	0	benign	0.01	neutral	0.51	neutral	1.01	neutral	0.04	neutral	0	low_impact	0.9	0.87	neutral	0.96	neutral	-0.58	0.14	neutral	0.62	0.65	0.44	neutral	0.11	neutral	0.2	neutral	0.31	neutral	4	0.47	neutral	0.75	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	0.24	medium_impact	-0.38	medium_impact	0.46	0.8	31.51	21.31	0.46	N	0.12	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13945	13945	A	T	MI.22684	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1609	537	I	F	Atc/Ttc	-4.87	0	0	possibly_damaging	0.83	neutral	0.71	neutral	0.88	neutral	-1.19	neutral	-0.96	low_impact	0.86	0.8	neutral	0.82	neutral	1.76	14.74	neutral	0.46	0.55	0.45	neutral	0.34	neutral	0.2	neutral	0.45	neutral	1	0.8	neutral	0.44	neutral	-3	neutral	0.62	deleterious	-1.4	low_impact	0.45	medium_impact	-0.42	medium_impact	0.75	0.85	31.51	21.31	0.28	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13946	13946	T	C	MI.22685	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1610	537	I	T	aTc/aCc	-9.69	0	0	benign	0.36	neutral	0.42	neutral	0.88	neutral	-1.13	neutral	-0.56	neutral_impact	0.43	0.81	neutral	0.99	neutral	1.37	12.62	neutral	0.39	0.5	0.47	neutral	0.13	neutral	0.23	neutral	0.26	neutral	5	0.51	neutral	0.53	deleterious	-6	neutral	0.50	deleterious	-0.51	medium_impact	0.16	medium_impact	-0.81	medium_impact	0.57	0.8	31.51	21.31	0.43	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13946	13946	T	G	MI.22686	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1610	537	I	S	aTc/aGc	-9.69	0	0	benign	0.36	neutral	0.44	neutral	0.85	neutral	-1.63	neutral	-0.73	low_impact	0.82	0.79	neutral	0.95	neutral	2.50	19.45	deleterious	0.33	0.5	0.53	disease	0.31	neutral	0.27	neutral	0.36	neutral	3	0.48	neutral	0.54	deleterious	-6	neutral	0.63	deleterious	-0.51	medium_impact	0.18	medium_impact	-0.45	medium_impact	0.56	0.8	31.51	21.31	0.39	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13946	13946	T	A	MI.22687	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1610	537	I	N	aTc/aAc	-9.69	0	0	benign	0.03	neutral	0.33	neutral	0.8	deleterious	-3.15	neutral	-1.49	low_impact	0.94	0.8	neutral	0.87	neutral	3.11	22.50	deleterious	0.28	0.45	0.69	disease	0.47	neutral	0.28	neutral	0.5	disease	0	0.65	neutral	0.65	deleterious	-6	neutral	0.74	deleterious	0.69	medium_impact	0.06	medium_impact	-0.34	medium_impact	0.54	0.8	31.51	21.31	0.34	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13947	13947	C	A	MI.22688	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1611	537	I	M	atC/atA	-1.89	0	0	possibly_damaging	0.87	neutral	0.23	neutral	0.91	neutral	-0.77	neutral	0.32	neutral_impact	0.74	0.79	neutral	0.97	neutral	2.52	19.59	deleterious	0.48	0.55	0.57	disease	0.12	neutral	0.18	neutral	0.33	neutral	3	0.91	neutral	0.18	neutral	-3	neutral	0.63	deleterious	-1.53	low_impact	-0.06	medium_impact	-0.53	medium_impact	0.76	0.85	31.51	21.31	0.56	P	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13947	13947	C	G	MI.22689	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1611	537	I	M	atC/atG	-1.89	0	0	possibly_damaging	0.87	neutral	0.23	neutral	0.91	neutral	-0.77	neutral	0.32	neutral_impact	0.74	0.79	neutral	0.97	neutral	2.09	16.76	deleterious	0.48	0.55	0.57	disease	0.12	neutral	0.18	neutral	0.33	neutral	3	0.91	neutral	0.18	neutral	-3	neutral	0.63	deleterious	-1.53	low_impact	-0.06	medium_impact	-0.53	medium_impact	0.76	0.85	31.51	21.31	0.56	P	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6088	6088	C	A	MI.2269	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	185	62	A	E	gCa/gAa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.77	deleterious	-3.06	high_impact	4.99	0.6	damaging	0.05	damaging	4.31	24.00	deleterious	0.11	0.55	0.81	disease	0.92	disease	0.66	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.71	0.9	2.53	6.59	0.75	P	0.76	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13948	13948	C	A	MI.22690	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1612	538	P	T	Ccc/Acc	-11.75	0	0	probably_damaging	1	neutral	0.42	neutral	0.9	neutral	-1.25	deleterious	-6.52	low_impact	1.49	0.82	neutral	0.94	neutral	3.80	23.40	deleterious	0.37	0.5	0.44	neutral	0.6	disease	0.54	disease	0.46	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.16	medium_impact	0.16	medium_impact	0.80	0.85	4.48	8.3	0.33	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13948	13948	C	G	MI.22691	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1612	538	P	A	Ccc/Gcc	-11.75	0	0	probably_damaging	1	neutral	0.54	neutral	0.92	neutral	-0.84	deleterious	-6.71	medium_impact	2.69	0.76	neutral	0.67	neutral	3.27	22.80	deleterious	0.39	0.5	0.47	neutral	0.5	disease	0.66	disease	0.59	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.27	medium_impact	1.25	medium_impact	0.84	0.9	4.48	8.3	0.33	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13948	13948	C	T	MI.22692	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1612	538	P	S	Ccc/Tcc	-11.75	0	0	probably_damaging	1	neutral	0.44	neutral	1.05	neutral	0.35	deleterious	-6.63	low_impact	1.57	0.83	neutral	0.96	neutral	4.03	23.70	deleterious	0.49	0.55	0.51	disease	0.54	disease	0.39	neutral	0.47	neutral	1	1	deleterious	0.22	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.18	medium_impact	0.23	medium_impact	0.33	0.8	4.48	8.3	0.34	N	0.78	polymorphism	1	0.09	rs878869470	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13949	13949	C	T	MI.22693	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1613	538	P	L	cCc/cTc	-0.29	0	0	probably_damaging	1	neutral	0.66	neutral	0.92	neutral	-0.89	deleterious	-8.47	high_impact	3.58	0.7	neutral	0.46	neutral	4.61	24.40	deleterious	0.44	0.55	0.53	disease	0.79	disease	0.64	disease	0.66	disease	3	1	deleterious	0.33	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.39	medium_impact	2.07	high_impact	0.86	0.9	4.48	8.3	0.29	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13949	13949	C	A	MI.22694	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1613	538	P	H	cCc/cAc	-0.29	0	0	probably_damaging	1	neutral	0.54	neutral	0.84	neutral	-2.97	deleterious	-7.56	high_impact	3.58	0.7	neutral	0.43	neutral	4.24	23.90	deleterious	0.28	0.45	0.75	disease	0.77	disease	0.76	disease	0.78	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.27	medium_impact	2.07	high_impact	0.73	0.85	4.48	8.3	0.3	N	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13949	13949	C	G	MI.22695	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1613	538	P	R	cCc/cGc	-0.29	0	0	probably_damaging	1	neutral	0.37	neutral	0.86	neutral	-1.99	deleterious	-7.62	high_impact	3.58	0.68	neutral	0.39	neutral	3.79	23.40	deleterious	0.26	0.45	0.61	disease	0.81	disease	0.78	disease	0.77	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.11	medium_impact	2.07	high_impact	0.74	0.85	4.48	8.3	0.38	N	0.64	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13951	13951	T	A	MI.22696	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1615	539	Y	N	Tat/Aat	-13.35	0	0	possibly_damaging	0.48	neutral	0.34	neutral	1.02	neutral	0.32	neutral	-2.36	neutral_impact	0.04	0.83	neutral	0.89	neutral	2.45	19.11	deleterious	0.45	0.55	0.39	neutral	0.43	neutral	0.28	neutral	0.49	neutral	0	0.63	neutral	0.43	neutral	-3	neutral	0.58	deleterious	-0.71	medium_impact	0.07	medium_impact	-1.17	low_impact	0.26	0.8	27.53	17.09	0.35	N	0.68	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13951	13951	T	C	MI.22697	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1615	539	Y	H	Tat/Cat	-13.35	0	0	benign	0.01	neutral	0.54	neutral	0.96	neutral	-1.17	neutral	-0.61	neutral_impact	-0.33	0.84	neutral	0.97	neutral	-0.15	1.38	neutral	0.55	0.6	0.52	disease	0.3	neutral	0.23	neutral	0.38	neutral	2	0.44	neutral	0.77	deleterious	-6	neutral	0.20	neutral	1.15	medium_impact	0.27	medium_impact	-1.5	low_impact	0.21	0.8	27.53	17.09	0.34	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13951	13951	T	G	MI.22698	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1615	539	Y	D	Tat/Gat	-13.35	0	0	possibly_damaging	0.69	neutral	0.19	neutral	0.98	neutral	-0.53	deleterious	-3.58	neutral_impact	0.77	0.82	neutral	0.79	neutral	2.78	21.30	deleterious	0.39	0.5	0.45	neutral	0.57	disease	0.48	neutral	0.49	neutral	0	0.84	neutral	0.25	neutral	-3	neutral	0.68	deleterious	-1.08	low_impact	-0.12	medium_impact	-0.5	medium_impact	0.31	0.8	27.53	17.09	0.35	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13952	13952	A	C	MI.22699	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1616	539	Y	S	tAt/tCt	-3.04	0	0	benign	0.04	neutral	0.51	neutral	1.05	neutral	0.77	deleterious	-2.68	neutral_impact	0	0.85	neutral	0.95	neutral	2.13	17.03	deleterious	0.31	0.45	0.27	neutral	0.34	neutral	0.29	neutral	0.46	neutral	1	0.44	neutral	0.74	deleterious	-6	neutral	0.58	deleterious	0.57	medium_impact	0.24	medium_impact	-1.2	low_impact	0.27	0.8	27.53	17.09	0.31	N	0.65	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8633	8633	A	G	MI.227	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	107	36	Y	C	tAt/tGt	2.9	0.2	0	possibly_damaging	0.65	neutral	0.15	neutral	4.38	neutral	-1.34	neutral	-2.27	low_impact	1.75	0.82	neutral	0.38	neutral	3.09	22.50	deleterious	0.45	0.65	0.86	disease	0.59	disease	0.53	disease	0.66	disease	3	0.86	neutral	0.25	neutral	-3	neutral	0.65	deleterious	-1.01	low_impact	-0.13	medium_impact	0.4	medium_impact	0.14	0.9	29.2	23.72	0.28	N	0.52	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6088	6088	C	T	MI.2270	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	185	62	A	V	gCa/gTa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.85	deleterious	-3.66	deleterious	-2.51	high_impact	4.43	0.6	neutral	0.03	damaging	4.30	24.00	deleterious	0.36	0.55	0.75	disease	0.91	disease	0.57	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.99	high_impact	0.76	0.9	2.53	6.59	0.55	P	0.75	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13952	13952	A	G	MI.22700	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1616	539	Y	C	tAt/tGt	-3.04	0	0	benign	0.06	neutral	0.16	neutral	0.93	deleterious	-3.1	deleterious	-3.76	low_impact	1.32	0.77	neutral	0.41	neutral	2.47	19.26	deleterious	0.35	0.5	0.86	disease	0.57	disease	0.53	disease	0.68	disease	4	0.83	neutral	0.55	deleterious	-6	neutral	0.75	deleterious	0.39	medium_impact	-0.17	medium_impact	0	medium_impact	0.12	0.8	27.53	17.09	0.31	N	0.63	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13952	13952	A	T	MI.22701	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1616	539	Y	F	tAt/tTt	-3.04	0	0	possibly_damaging	0.64	neutral	0.74	neutral	0.97	neutral	-0.88	neutral	-1.59	low_impact	0.97	0.8	neutral	0.9	neutral	1.39	12.76	neutral	0.47	0.55	0.5	disease	0.32	neutral	0.33	neutral	0.26	neutral	5	0.56	neutral	0.55	deleterious	-3	neutral	0.60	deleterious	-0.98	medium_impact	0.48	medium_impact	-0.32	medium_impact	0.28	0.8	27.53	17.09	0.23	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13954	13954	C	A	MI.22702	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1618	540	L	M	Cta/Ata	-3.73	0	0	possibly_damaging	0.86	neutral	0.31	neutral	0.84	neutral	-1.74	neutral	-0.06	neutral_impact	0.69	0.84	neutral	0.99	neutral	2.42	18.95	deleterious	0.38	0.5	0.58	disease	0.08	neutral	0.13	neutral	0.36	neutral	3	0.88	neutral	0.23	neutral	-3	neutral	0.63	deleterious	-1.5	low_impact	0.04	medium_impact	-0.57	medium_impact	0.69	0.85	33	21.8	0.55	P	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13954	13954	C	G	MI.22703	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1618	540	L	V	Cta/Gta	-3.73	0	0	benign	0.27	neutral	0.5	neutral	0.91	neutral	-0.79	neutral	-0.8	medium_impact	2.16	0.86	neutral	0.94	neutral	0.67	8.63	deleterious	0.38	0.5	0.42	neutral	0.2	neutral	0.31	neutral	0.4	neutral	2	0.4	neutral	0.62	deleterious	-3	neutral	0.40	neutral	-0.34	medium_impact	0.23	medium_impact	0.77	medium_impact	0.40	0.8	33	21.8	0.39	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13955	13955	T	A	MI.22704	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1619	540	L	Q	cTa/cAa	-4.64	0	0	benign	0.02	neutral	0.3	neutral	0.8	neutral	-2.94	neutral	-1.13	neutral_impact	0.71	0.81	neutral	0.75	neutral	2.94	22.00	deleterious	0.29	0.45	0.63	disease	0.44	neutral	0.23	neutral	0.58	disease	2	0.69	neutral	0.64	deleterious	-6	neutral	0.69	deleterious	0.86	medium_impact	0.03	medium_impact	-0.55	medium_impact	0.51	0.8	33	21.8	0.35	N	0.08	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13955	13955	T	C	MI.22705	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1619	540	L	P	cTa/cCa	-4.64	0	0	possibly_damaging	0.54	neutral	0.2	neutral	0.79	deleterious	-3.15	neutral	-2.3	medium_impact	2.16	0.74	neutral	0.44	neutral	3.92	23.50	deleterious	0.2	0.45	0.43	neutral	0.7	disease	0.53	disease	0.62	disease	2	0.79	neutral	0.33	neutral	0	NA	0.71	deleterious	-0.81	medium_impact	-0.1	medium_impact	0.77	medium_impact	0.46	0.8	33	21.8	0.34	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13955	13955	T	G	MI.22706	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1619	540	L	R	cTa/cGa	-4.64	0	0	benign	0.37	neutral	0.34	neutral	0.81	neutral	-2.51	neutral	-1.27	medium_impact	2.5	0.73	neutral	0.65	neutral	4.18	23.80	deleterious	0.27	0.45	0.55	disease	0.6	disease	0.53	disease	0.6	disease	2	0.6	neutral	0.49	deleterious	-3	neutral	0.69	deleterious	-0.53	medium_impact	0.07	medium_impact	1.08	medium_impact	0.44	0.8	33	21.8	0.31	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13957	13957	G	C	MI.22707	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1621	541	G	R	Ggc/Cgc	-2.12	0	0	possibly_damaging	0.46	neutral	0.35	neutral	0.99	neutral	-0.25	neutral	-0.32	low_impact	0.8	0.77	neutral	0.44	neutral	3.88	23.50	deleterious	0.31	0.45	0.47	neutral	0.58	disease	0.53	disease	0.62	disease	2	0.61	neutral	0.45	neutral	-3	neutral	0.69	deleterious	-0.68	medium_impact	0.08	medium_impact	-0.47	medium_impact	0.89	0.9	15.42	10.94	0.29	N	0.22	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13957	13957	G	T	MI.22708	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1621	541	G	C	Ggc/Tgc	-2.12	0	0	probably_damaging	0.93	neutral	0.18	neutral	0.96	neutral	-2.19	neutral	-1.39	low_impact	0.8	0.78	neutral	0.46	neutral	4.23	23.90	deleterious	0.26	0.45	0.8	disease	0.56	disease	0.24	neutral	0.55	disease	1	0.96	neutral	0.13	neutral	-2	neutral	0.75	deleterious	-1.81	low_impact	-0.13	medium_impact	-0.47	medium_impact	0.72	0.85	15.42	10.94	0.32	N	0.52	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13957	13957	G	A	MI.22709	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1621	541	G	S	Ggc/Agc	-2.12	0	0	benign	0.02	neutral	0.42	neutral	1.16	neutral	2.02	neutral	1.47	neutral_impact	-1.17	0.88	neutral	0.98	neutral	0.78	9.36	deleterious	0.43	0.55	0.33	neutral	0.13	neutral	0.11	neutral	0.25	neutral	5	0.56	neutral	0.7	deleterious	-6	neutral	0.13	neutral	0.86	medium_impact	0.16	medium_impact	-2.27	low_impact	0.79	0.85	15.42	10.94	0.51	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6090	6090	T	G	MI.2271	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	187	63	F	V	Ttt/Gtt	-8.2	0	0	probably_damaging	1	deleterious	0	neutral	2.93	neutral	1.59	deleterious	-3.64	medium_impact	2.86	0.61	neutral	0.56	neutral	3.94	23.50	deleterious	0.27	0.55	0.24	neutral	0.9	disease	0.41	neutral	0.55	disease	1	1	deleterious	0	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	1.54	medium_impact	0.55	0.9	1.95	6.88	0.4	N	0.84	polymorphism	0.78	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13958	13958	G	T	MI.22710	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1622	541	G	V	gGc/gTc	-0.29	0	0	possibly_damaging	0.46	neutral	0.51	neutral	1.04	neutral	0.82	neutral	-1.32	neutral_impact	-0.17	0.85	neutral	0.9	neutral	3.65	23.20	deleterious	0.25	0.45	0.28	neutral	0.38	neutral	0.33	neutral	0.45	neutral	1	0.46	neutral	0.53	deleterious	-3	neutral	0.58	deleterious	-0.68	medium_impact	0.24	medium_impact	-1.36	low_impact	0.62	0.8	15.42	10.94	0.3	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13958	13958	G	A	MI.22711	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1622	541	G	D	gGc/gAc	-0.29	0	0	benign	0.27	neutral	0.21	neutral	0.98	neutral	-0.55	neutral	0.23	low_impact	0.8	0.83	neutral	0.77	neutral	3.67	23.20	deleterious	0.21	0.45	0.57	disease	0.55	disease	0.48	neutral	0.49	neutral	0	0.75	neutral	0.47	deleterious	-6	neutral	0.62	deleterious	-0.34	medium_impact	-0.09	medium_impact	-0.47	medium_impact	0.44	0.8	15.42	10.94	0.4	N	0.15	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13958	13958	G	C	MI.22712	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1622	541	G	A	gGc/gCc	-0.29	0	0	benign	0.18	neutral	0.51	neutral	1.03	neutral	0.63	neutral	-0.22	neutral_impact	-0.4	0.87	neutral	0.87	neutral	1.54	13.51	neutral	0.47	0.55	0.33	neutral	0.17	neutral	0.26	neutral	0.31	neutral	4	0.39	neutral	0.67	deleterious	-6	neutral	0.38	neutral	-0.12	medium_impact	0.24	medium_impact	-1.57	low_impact	0.76	0.85	15.42	10.94	0.32	N	0.19	polymorphism	1	0.00	rs202081448	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13960	13960	C	A	MI.22713	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1624	542	L	I	Ctt/Att	-4.42	0	0	probably_damaging	1	neutral	0.44	neutral	0.03	deleterious	-3.9	neutral	-1.77	high_impact	3.77	0.54	damaging	0.09	damaging	4.32	24.00	deleterious	0.42	0.55	0.76	disease	0.48	neutral	0.68	disease	0.65	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.18	medium_impact	2.24	high_impact	0.68	0.85	9.78	7.01	0.28	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13960	13960	C	T	MI.22714	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1624	542	L	F	Ctt/Ttt	-4.42	0	0	probably_damaging	1	neutral	0.71	neutral	0.02	deleterious	-4.08	deleterious	-3.53	medium_impact	2.19	0.54	damaging	0.08	damaging	4.15	23.80	deleterious	0.42	0.55	0.68	disease	0.52	disease	0.55	disease	0.49	neutral	0	1	deleterious	0.36	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.45	medium_impact	0.8	medium_impact	0.63	0.8	9.78	7.01	0.19	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13960	13960	C	G	MI.22715	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1624	542	L	V	Ctt/Gtt	-4.42	0	0	probably_damaging	1	neutral	0.53	neutral	0.03	deleterious	-3.89	deleterious	-2.65	high_impact	3.77	0.49	damaging	0.07	damaging	3.64	23.20	deleterious	0.4	0.5	0.64	disease	0.48	neutral	0.69	disease	0.63	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.76	deleterious	-3.6	low_impact	0.26	medium_impact	2.24	high_impact	0.62	0.8	9.78	7.01	0.28	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13961	13961	T	A	MI.22716	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1625	542	L	H	cTt/cAt	-0.52	0	0	probably_damaging	1	neutral	0.56	neutral	-0.06	deleterious	-7.34	deleterious	-6.17	high_impact	3.77	0.53	damaging	0.09	damaging	4.26	23.90	deleterious	0.16	0.45	0.61	disease	0.75	disease	0.78	disease	0.76	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.29	medium_impact	2.24	high_impact	0.53	0.8	9.78	7.01	0.33	N	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13961	13961	T	C	MI.22717	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1625	542	L	P	cTt/cCt	-0.52	0	0	probably_damaging	1	neutral	0.21	neutral	-0.06	deleterious	-7.28	deleterious	-6.18	high_impact	3.77	0.49	damaging	0.06	damaging	3.99	23.60	deleterious	0.14	0.4	0.83	disease	0.76	disease	0.81	disease	0.83	disease	7	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.09	medium_impact	2.24	high_impact	0.42	0.8	9.78	7.01	0.36	N	0.99	polymorphism	0.9	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13961	13961	T	G	MI.22718	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1625	542	L	R	cTt/cGt	-0.52	0	0	probably_damaging	1	neutral	0.43	neutral	-0.05	deleterious	-6.74	deleterious	-5.3	high_impact	3.77	0.49	damaging	0.07	damaging	4.37	24.10	deleterious	0.12	0.4	0.4	neutral	0.81	disease	0.8	disease	0.79	disease	6	1	deleterious	0.22	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.17	medium_impact	2.24	high_impact	0.63	0.8	9.78	7.01	0.38	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13963	13963	C	G	MI.22719	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1627	543	L	V	Ctt/Gtt	-1.89	0	0	benign	0.04	neutral	0.5	neutral	1	neutral	-0.03	neutral	-0.4	neutral_impact	0.64	0.83	neutral	0.83	neutral	0.30	5.66	deleterious	0.53	0.6	0.45	neutral	0.11	neutral	0.28	neutral	0.29	neutral	4	0.46	neutral	0.73	deleterious	-6	neutral	0.24	neutral	0.57	medium_impact	0.23	medium_impact	-0.62	medium_impact	0.41	0.8	32.01	17.13	0.39	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6090	6090	T	C	MI.2272	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	187	63	F	L	Ttt/Ctt	-8.2	0	0	probably_damaging	0.99	neutral	0.19	neutral	2.95	neutral	1.58	deleterious	-2.79	low_impact	1.23	0.56	damaging	0.64	neutral	2.77	21.20	deleterious	0.44	0.55	0.18	neutral	0.61	disease	0.34	neutral	0.4	neutral	2	0.99	deleterious	0.1	neutral	-2	neutral	0.68	deleterious	-2.64	low_impact	-0.16	medium_impact	0.04	medium_impact	0.60	0.9	1.95	6.88	0.42	N	0.83	polymorphism	0.87	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13963	13963	C	A	MI.22720	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1627	543	L	I	Ctt/Att	-1.89	0	0	benign	0.03	neutral	0.5	neutral	0.98	neutral	-0.2	neutral	-0.49	neutral_impact	-0.14	0.84	neutral	0.92	neutral	0.69	8.74	deleterious	0.42	0.5	0.66	disease	0.1	neutral	0.15	neutral	0.38	neutral	2	0.47	neutral	0.74	deleterious	-6	neutral	0.16	neutral	0.69	medium_impact	0.23	medium_impact	-1.33	low_impact	0.58	0.8	32.01	17.13	0.39	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13963	13963	C	T	MI.22721	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1627	543	L	F	Ctt/Ttt	-1.89	0	0	possibly_damaging	0.69	neutral	0.7	neutral	0.93	neutral	-1.22	neutral	-1.21	neutral_impact	-0.14	0.84	neutral	0.83	neutral	2.54	19.73	deleterious	0.47	0.55	0.71	disease	0.2	neutral	0.16	neutral	0.45	neutral	1	0.62	neutral	0.51	deleterious	-3	neutral	0.65	deleterious	-1.08	low_impact	0.44	medium_impact	-1.33	low_impact	0.54	0.8	32.01	17.13	0.32	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13964	13964	T	A	MI.22722	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1628	543	L	H	cTt/cAt	-4.87	0	0	probably_damaging	0.95	neutral	0.5	neutral	0.91	neutral	-1.89	neutral	-1.06	neutral_impact	0.12	0.83	neutral	0.91	neutral	2.70	20.80	deleterious	0.27	0.45	0.48	neutral	0.35	neutral	0.25	neutral	0.41	neutral	2	0.95	neutral	0.28	neutral	-2	neutral	0.68	deleterious	-1.96	low_impact	0.23	medium_impact	-1.09	low_impact	0.46	0.8	32.01	17.13	0.32	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13964	13964	T	C	MI.22723	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1628	543	L	P	cTt/cCt	-4.87	0	0	possibly_damaging	0.87	neutral	0.22	neutral	0.9	neutral	-2.6	neutral	-1.43	low_impact	1.45	0.63	neutral	0.42	neutral	2.79	21.30	deleterious	0.24	0.45	0.55	disease	0.66	disease	0.52	disease	0.61	disease	2	0.91	neutral	0.18	neutral	-3	neutral	0.75	deleterious	-1.53	low_impact	-0.07	medium_impact	0.12	medium_impact	0.37	0.8	32.01	17.13	0.31	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13964	13964	T	G	MI.22724	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1628	543	L	R	cTt/cGt	-4.87	0	0	possibly_damaging	0.83	neutral	0.32	neutral	0.92	neutral	-1.41	neutral	-0.62	neutral_impact	0.12	0.77	neutral	0.66	neutral	3.07	22.40	deleterious	0.3	0.45	0.44	neutral	0.53	disease	0.49	neutral	0.5	neutral	0	0.85	neutral	0.25	neutral	-3	neutral	0.68	deleterious	-1.4	low_impact	0.05	medium_impact	-1.09	low_impact	0.57	0.8	32.01	17.13	0.29	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13966	13966	A	T	MI.22725	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1630	544	T	S	Acg/Tcg	-5.79	0	0.05	benign	0.27	neutral	0.47	neutral	0.96	neutral	-0.61	neutral	-0.82	neutral_impact	0.7	0.84	neutral	0.83	neutral	0.45	7.04	deleterious	0.46	0.55	0.35	neutral	0.13	neutral	0.39	neutral	0.31	neutral	4	0.43	neutral	0.6	deleterious	-6	neutral	0.19	neutral	-0.34	medium_impact	0.2	medium_impact	-0.56	medium_impact	0.39	0.8	15.75	12.07	0.39	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13966	13966	A	C	MI.22726	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1630	544	T	P	Acg/Ccg	-5.79	0	0.05	possibly_damaging	0.66	neutral	0.23	neutral	0.9	neutral	-2.85	neutral	-2.24	medium_impact	2.19	0.76	neutral	0.51	neutral	2.08	16.70	deleterious	0.21	0.45	0.82	disease	0.65	disease	0.66	disease	0.74	disease	5	0.8	neutral	0.29	neutral	0	NA	0.61	deleterious	-1.02	low_impact	-0.06	medium_impact	0.8	medium_impact	0.47	0.8	15.75	12.07	0.28	N	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13966	13966	A	G	MI.22727	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1630	544	T	A	Acg/Gcg	-5.79	0	0.05	benign	0.01	neutral	0.56	neutral	0.96	neutral	-0.59	neutral	-0.76	low_impact	1.09	0.91	neutral	0.94	neutral	0.51	7.54	deleterious	0.61	0.65	0.34	neutral	0.15	neutral	0.4	neutral	0.31	neutral	4	0.43	neutral	0.78	deleterious	-6	neutral	0.12	neutral	1.15	medium_impact	0.29	medium_impact	-0.21	medium_impact	0.27	0.8	15.75	12.07	0.31	N	0.19	polymorphism	1	0.01	rs41535848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13967	13967	C	A	MI.22728	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1631	544	T	K	aCg/aAg	-4.42	0	0	possibly_damaging	0.46	neutral	0.36	neutral	0.91	neutral	-1.88	neutral	-1.78	low_impact	1.16	0.82	neutral	0.76	neutral	2.76	21.10	deleterious	0.27	0.45	0.75	disease	0.43	neutral	0.64	disease	0.66	disease	3	0.6	neutral	0.45	neutral	-3	neutral	0.42	neutral	-0.68	medium_impact	0.1	medium_impact	-0.14	medium_impact	0.46	0.8	15.75	12.07	0.33	N	0.40	polymorphism	1	0.02	rs386829197	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13967	13967	C	T	MI.22729	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1631	544	T	M	aCg/aTg	-4.42	0	0	benign	0.03	neutral	0.25	neutral	0.99	neutral	-0.07	neutral	0.85	neutral_impact	-0.04	0.89	neutral	0.98	neutral	-0.18	1.23	neutral	0.35	0.5	0.43	neutral	0.11	neutral	0.2	neutral	0.32	neutral	4	0.74	neutral	0.61	deleterious	-6	neutral	0.12	neutral	0.69	medium_impact	-0.03	medium_impact	-1.24	low_impact	0.52	0.8	15.75	12.07	0.52	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	C13967T	Possible LHON factor	+	-	Reported	3	.	P	P	neutral
chrM	6090	6090	T	A	MI.2273	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	187	63	F	I	Ttt/Att	-8.2	0	0	probably_damaging	0.99	neutral	0.28	neutral	2.9	neutral	0.97	deleterious	-3	medium_impact	2.88	0.66	neutral	0.66	neutral	4.25	23.90	deleterious	0.31	0.55	0.18	neutral	0.87	disease	0.38	neutral	0.53	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-2.64	low_impact	-0.04	medium_impact	1.56	medium_impact	0.57	0.9	1.95	6.88	0.43	N	0.88	polymorphism	0.88	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13969	13969	A	T	MI.22730	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1633	545	S	C	Agc/Tgc	-5.33	0	0	probably_damaging	0.99	neutral	0.17	neutral	0.63	deleterious	-5.29	deleterious	-4.34	medium_impact	3.13	0.63	neutral	0.41	neutral	3.64	23.20	deleterious	0.33	0.5	0.93	disease	0.67	disease	0.58	disease	0.79	disease	6	0.99	deleterious	0.09	neutral	1	deleterious	0.81	deleterious	-2.64	low_impact	-0.15	medium_impact	1.66	medium_impact	0.61	0.8	14.1	15.36	0.32	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13969	13969	A	C	MI.22731	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1633	545	S	R	Agc/Cgc	-5.33	0	0	probably_damaging	0.94	neutral	0.35	neutral	0.64	deleterious	-3.91	deleterious	-4.31	medium_impact	3.13	0.63	neutral	0.41	neutral	4.03	23.60	deleterious	0.2	0.45	0.45	neutral	0.84	disease	0.78	disease	0.8	disease	6	0.95	neutral	0.21	neutral	1	deleterious	0.80	deleterious	-1.88	low_impact	0.08	medium_impact	1.66	medium_impact	0.62	0.8	14.1	15.36	0.4	N	0.96	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13969	13969	A	G	MI.22732	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1633	545	S	G	Agc/Ggc	-5.33	0	0	benign	0.12	neutral	0.34	neutral	1.24	neutral	0.83	deleterious	-3.16	neutral_impact	-0.14	0.78	neutral	0.92	neutral	1.07	11.06	neutral	0.38	0.5	0.38	neutral	0.05	neutral	0.27	neutral	0.19	neutral	6	0.61	neutral	0.61	deleterious	-6	neutral	0.67	deleterious	0.08	medium_impact	0.07	medium_impact	-1.33	low_impact	0.61	0.8	14.1	15.36	0.42	N	0.30	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13970	13970	G	C	MI.22733	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1634	545	S	T	aGc/aCc	0.86	0.54	0	possibly_damaging	0.86	neutral	0.41	neutral	0.67	deleterious	-3.02	deleterious	-2.61	medium_impact	3.13	0.68	neutral	0.55	neutral	3.59	23.20	deleterious	0.29	0.45	0.51	disease	0.39	neutral	0.67	disease	0.53	disease	1	0.86	neutral	0.28	neutral	0	NA	0.73	deleterious	-1.5	low_impact	0.15	medium_impact	1.66	medium_impact	0.61	0.8	14.1	15.36	0.34	N	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13970	13970	G	A	MI.22734	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1634	545	S	N	aGc/aAc	0.86	0.54	0	benign	0.17	neutral	0.34	neutral	0.65	deleterious	-3.77	deleterious	-2.54	medium_impact	2.58	0.81	neutral	0.52	neutral	3.70	23.30	deleterious	0.65	0.7	0.65	disease	0.64	disease	0.62	disease	0.67	disease	3	0.6	neutral	0.59	deleterious	-3	neutral	0.79	deleterious	-0.09	medium_impact	0.07	medium_impact	1.15	medium_impact	0.52	0.8	14.1	15.36	0.28	N	0.59	polymorphism	1	0.08	.	.	.	.	.	.	COSM6716775	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13970	13970	G	T	MI.22735	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1634	545	S	I	aGc/aTc	0.86	0.54	0	probably_damaging	0.98	neutral	0.4	neutral	0.64	deleterious	-4.28	deleterious	-5.17	medium_impact	3.13	0.68	neutral	0.52	neutral	4.34	24.00	deleterious	0.33	0.5	0.82	disease	0.72	disease	0.69	disease	0.76	disease	5	0.98	neutral	0.21	neutral	1	deleterious	0.82	deleterious	-2.35	low_impact	0.14	medium_impact	1.66	medium_impact	0.62	0.8	14.1	15.36	0.3	N	0.97	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13972	13972	C	A	MI.22736	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1636	546	Q	K	Caa/Aaa	-1.44	0	0	probably_damaging	1	neutral	0.35	neutral	0.79	neutral	-1.6	deleterious	-2.96	medium_impact	2.88	0.67	neutral	0.52	neutral	4.07	23.70	deleterious	0.41	0.5	0.45	neutral	0.72	disease	0.63	disease	0.63	disease	3	1	deleterious	0.18	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.08	medium_impact	1.43	medium_impact	0.44	0.8	12.77	12.9	0.33	N	0.71	polymorphism	0.68	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13972	13972	C	G	MI.22737	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1636	546	Q	E	Caa/Gaa	-1.44	0	0	probably_damaging	1	neutral	0.28	neutral	0.79	neutral	-1.62	neutral	-2.27	medium_impact	2.64	0.67	neutral	0.46	neutral	3.25	22.80	deleterious	0.41	0.5	0.44	neutral	0.6	disease	0.63	disease	0.59	disease	2	1	deleterious	0.14	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.01	medium_impact	1.21	medium_impact	0.41	0.8	12.77	12.9	0.35	N	0.74	polymorphism	0.81	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13973	13973	A	C	MI.22738	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1637	546	Q	P	cAa/cCa	2.23	0.77	0.01	probably_damaging	1	neutral	0.21	neutral	0.7	deleterious	-3.9	deleterious	-4.58	high_impact	3.68	0.6	neutral	0.3	neutral	3.49	23.10	deleterious	0.19	0.45	0.81	disease	0.81	disease	0.78	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.09	medium_impact	2.16	high_impact	0.40	0.8	12.77	12.9	0.44	N	0.97	disease_causing	0.96	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13973	13973	A	G	MI.22739	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1637	546	Q	R	cAa/cGa	2.23	0.77	0.01	probably_damaging	1	neutral	0.35	neutral	0.74	neutral	-2.49	deleterious	-2.92	medium_impact	3.13	0.65	neutral	0.61	neutral	3.61	23.20	deleterious	0.48	0.55	0.46	neutral	0.74	disease	0.69	disease	0.65	disease	3	1	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.08	medium_impact	1.66	medium_impact	0.34	0.8	12.77	12.9	0.33	N	0.62	disease_causing	0.56	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6091	6091	T	A	MI.2274	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	188	63	F	Y	tTt/tAt	5.91	1	0	probably_damaging	0.99	deleterious	0	neutral	2.79	neutral	-1.22	neutral	-1.71	high_impact	4.75	0.64	neutral	0.51	neutral	4.15	23.80	deleterious	0.36	0.55	0.47	neutral	0.84	disease	0.57	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	3.29	high_impact	0.65	0.9	1.95	6.88	0.69	P	0.59	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13973	13973	A	T	MI.22740	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1637	546	Q	L	cAa/cTa	2.23	0.77	0.01	probably_damaging	1	neutral	0.69	neutral	0.76	neutral	-1.98	deleterious	-4.66	medium_impact	2.64	0.81	neutral	0.8	neutral	3.98	23.60	deleterious	0.27	0.45	0.57	disease	0.78	disease	0.58	disease	0.56	disease	1	1	deleterious	0.35	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.42	medium_impact	1.21	medium_impact	0.21	0.8	12.77	12.9	0.24	N	0.65	disease_causing	0.95	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13974	13974	A	C	MI.22741	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1638	546	Q	H	caA/caC	3.61	0.8	0	probably_damaging	1	neutral	0.54	neutral	0.71	deleterious	-3.14	deleterious	-3.29	medium_impact	2.33	0.73	neutral	0.46	neutral	3.48	23.10	deleterious	0.51	0.6	0.71	disease	0.68	disease	0.61	disease	0.61	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.27	medium_impact	0.93	medium_impact	0.56	0.8	12.77	12.9	0.28	N	0.67	disease_causing	0.91	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13974	13974	A	T	MI.22742	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1638	546	Q	H	caA/caT	3.61	0.8	0	probably_damaging	1	neutral	0.54	neutral	0.71	deleterious	-3.14	deleterious	-3.29	medium_impact	2.33	0.73	neutral	0.46	neutral	3.69	23.30	deleterious	0.51	0.6	0.71	disease	0.68	disease	0.61	disease	0.61	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.27	medium_impact	0.93	medium_impact	0.56	0.8	12.77	12.9	0.29	N	0.67	disease_causing	0.91	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13975	13975	A	C	MI.22743	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1639	547	N	H	Aac/Cac	0.63	0.28	0	probably_damaging	1	neutral	0.53	neutral	0.9	neutral	-1.81	deleterious	-3.24	low_impact	1.11	0.84	neutral	0.81	neutral	1.58	13.73	neutral	0.59	0.65	0.58	disease	0.23	neutral	0.33	neutral	0.55	disease	1	1	deleterious	0.27	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.26	medium_impact	-0.19	medium_impact	0.36	0.8	29.68	24.23	0.27	N	0.43	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13975	13975	A	G	MI.22744	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1639	547	N	D	Aac/Gac	0.63	0.28	0	probably_damaging	1	neutral	0.2	neutral	0.9	neutral	-1.88	deleterious	-3.2	medium_impact	2.36	0.8	neutral	0.41	neutral	2.73	21.00	deleterious	0.68	0.7	0.38	neutral	0.24	neutral	0.46	neutral	0.46	neutral	1	1	deleterious	0.1	neutral	1	deleterious	0.66	deleterious	-3.6	low_impact	-0.1	medium_impact	0.95	medium_impact	0.36	0.8	29.68	24.23	0.34	N	0.67	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13975	13975	A	T	MI.22745	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1639	547	N	Y	Aac/Tac	0.63	0.28	0	probably_damaging	1	neutral	1	neutral	0.91	neutral	-1.51	deleterious	-5.17	low_impact	1.66	0.82	neutral	0.42	neutral	2.31	18.24	deleterious	0.32	0.5	0.69	disease	0.27	neutral	0.35	neutral	0.57	disease	1	1	deleterious	0.5	deleterious	-2	neutral	0.71	deleterious	-3.6	low_impact	1.89	high_impact	0.31	medium_impact	0.31	0.8	29.68	24.23	0.2	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13976	13976	A	G	MI.22746	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1640	547	N	S	aAc/aGc	1.54	0.23	0	probably_damaging	1	neutral	0.43	neutral	0.97	neutral	-0.34	deleterious	-2.94	low_impact	1.25	0.81	neutral	0.59	neutral	1.32	12.40	neutral	0.74	0.75	0.29	neutral	0.12	neutral	0.27	neutral	0.31	neutral	4	1	deleterious	0.22	neutral	-2	neutral	0.64	deleterious	-3.6	low_impact	0.17	medium_impact	-0.06	medium_impact	0.17	0.8	29.68	24.23	0.31	N	0.33	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13976	13976	A	T	MI.22747	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1640	547	N	I	aAc/aTc	1.54	0.23	0	probably_damaging	1	neutral	0.47	neutral	0.95	neutral	-0.75	deleterious	-6.08	low_impact	1.8	0.82	neutral	0.41	neutral	2.77	21.20	deleterious	0.28	0.45	0.65	disease	0.29	neutral	0.43	neutral	0.59	disease	2	1	deleterious	0.24	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.2	medium_impact	0.44	medium_impact	0.30	0.8	29.68	24.23	0.26	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13976	13976	A	C	MI.22748	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1640	547	N	T	aAc/aCc	1.54	0.23	0	probably_damaging	1	neutral	0.44	neutral	0.98	neutral	-0.23	deleterious	-3.58	low_impact	1.03	0.81	neutral	0.69	neutral	1.39	12.72	neutral	0.51	0.6	0.33	neutral	0.07	neutral	0.22	neutral	0.24	neutral	5	1	deleterious	0.22	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.18	medium_impact	-0.26	medium_impact	0.35	0.8	29.68	24.23	0.34	N	0.42	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13977	13977	C	G	MI.22749	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1641	547	N	K	aaC/aaG	0.4	0.02	0	probably_damaging	1	neutral	0.32	neutral	1.07	neutral	0.65	deleterious	-2.59	neutral_impact	0.78	0.8	neutral	0.91	neutral	1.49	13.25	neutral	0.62	0.65	0.18	neutral	0.09	neutral	0.23	neutral	0.24	neutral	5	1	deleterious	0.16	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.05	medium_impact	-0.49	medium_impact	0.43	0.8	29.68	24.23	0.4	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6091	6091	T	C	MI.2275	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	188	63	F	S	tTt/tCt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.83	neutral	-0.4	deleterious	-4.48	high_impact	4.06	0.72	neutral	0.64	neutral	4.12	23.80	deleterious	0.32	0.55	0.29	neutral	0.88	disease	0.57	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.65	high_impact	0.48	0.9	1.95	6.88	0.53	P	0.84	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13977	13977	C	A	MI.22750	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1641	547	N	K	aaC/aaA	0.4	0.02	0	probably_damaging	1	neutral	0.32	neutral	1.07	neutral	0.65	deleterious	-2.59	neutral_impact	0.78	0.8	neutral	0.91	neutral	1.96	15.94	deleterious	0.62	0.65	0.18	neutral	0.09	neutral	0.23	neutral	0.24	neutral	5	1	deleterious	0.16	neutral	-2	neutral	0.63	deleterious	-3.6	low_impact	0.05	medium_impact	-0.49	medium_impact	0.43	0.8	29.68	24.23	0.4	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13978	13978	C	A	MI.22751	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1642	548	L	M	Ctg/Atg	-5.79	0	0	benign	0.41	neutral	0.23	neutral	0.77	neutral	-1.87	neutral	-0.43	neutral_impact	-0.02	0.88	neutral	0.99	neutral	2.36	18.57	deleterious	0.31	0.45	0.52	disease	0.15	neutral	0.19	neutral	0.27	neutral	5	0.73	neutral	0.41	neutral	-6	neutral	0.66	deleterious	-0.6	medium_impact	-0.06	medium_impact	-1.22	low_impact	0.65	0.8	32.34	19.98	0.51	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13978	13978	C	G	MI.22752	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1642	548	L	V	Ctg/Gtg	-5.79	0	0	benign	0.05	neutral	0.5	neutral	0.84	neutral	-1.08	neutral	-1.1	low_impact	0.8	0.89	neutral	0.92	neutral	2.23	17.72	deleterious	0.41	0.5	0.3	neutral	0.15	neutral	0.21	neutral	0.31	neutral	4	0.45	neutral	0.73	deleterious	-6	neutral	0.64	deleterious	0.47	medium_impact	0.23	medium_impact	-0.47	medium_impact	0.32	0.8	32.34	19.98	0.44	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13979	13979	T	G	MI.22753	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1643	548	L	R	cTg/cGg	-2.35	0	0	probably_damaging	0.93	neutral	0.35	neutral	0.7	deleterious	-3.78	deleterious	-3.34	low_impact	1.84	0.68	neutral	0.53	neutral	4.39	24.10	deleterious	0.25	0.45	0.52	disease	0.74	disease	0.69	disease	0.75	disease	5	0.94	neutral	0.21	neutral	-2	neutral	0.78	deleterious	-1.81	low_impact	0.08	medium_impact	0.48	medium_impact	0.42	0.8	32.34	19.98	0.28	N	0.71	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13979	13979	T	C	MI.22754	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1643	548	L	P	cTg/cCg	-2.35	0	0	probably_damaging	0.97	neutral	0.2	neutral	0.69	deleterious	-4.42	deleterious	-3.88	low_impact	1.5	0.61	neutral	0.46	neutral	4.07	23.70	deleterious	0.17	0.45	0.72	disease	0.77	disease	0.69	disease	0.78	disease	6	0.98	neutral	0.12	neutral	-2	neutral	0.83	deleterious	-2.18	low_impact	-0.1	medium_impact	0.17	medium_impact	0.49	0.8	32.34	19.98	0.28	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13979	13979	T	A	MI.22755	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1643	548	L	Q	cTg/cAg	-2.35	0	0	probably_damaging	0.95	neutral	0.31	neutral	0.69	deleterious	-3.92	deleterious	-3.1	low_impact	1.5	0.75	neutral	0.64	neutral	4.37	24.10	deleterious	0.25	0.45	0.51	disease	0.48	neutral	0.56	disease	0.58	disease	2	0.96	neutral	0.18	neutral	-2	neutral	0.71	deleterious	-1.96	low_impact	0.04	medium_impact	0.17	medium_impact	0.45	0.8	32.34	19.98	0.33	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13981	13981	C	A	MI.22756	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1645	549	P	T	Ccc/Acc	-3.73	0	0	benign	0.01	neutral	0.62	neutral	1.06	neutral	2.11	neutral	0.84	neutral_impact	-1.5	0.79	neutral	0.81	neutral	2.10	16.85	deleterious	0.32	0.5	0.42	neutral	0.07	neutral	0.24	neutral	0.28	neutral	4	0.36	neutral	0.81	deleterious	-6	neutral	0.30	neutral	1.15	medium_impact	0.35	medium_impact	-2.57	low_impact	0.46	0.8	15.75	11.72	0.32	N	0.24	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13981	13981	C	G	MI.22757	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1645	549	P	A	Ccc/Gcc	-3.73	0	0	benign	0	neutral	0.57	neutral	1.27	neutral	4.1	neutral	3.19	neutral_impact	-3.48	0.8	neutral	0.96	neutral	-1.41	0.00	neutral	0.33	0.5	0.25	neutral	0.04	neutral	0.11	neutral	0.24	neutral	5	0.43	neutral	0.79	deleterious	-6	neutral	0.10	neutral	2.1	high_impact	0.3	medium_impact	-4.38	low_impact	0.58	0.8	15.75	11.72	0.39	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13981	13981	C	T	MI.22758	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1645	549	P	S	Ccc/Tcc	-3.73	0	0	benign	0.01	neutral	0.42	neutral	1.1	neutral	2.74	neutral	1.8	neutral_impact	-2.27	0.84	neutral	0.95	neutral	0.92	10.21	neutral	0.39	0.5	0.28	neutral	0.07	neutral	0.14	neutral	0.29	neutral	4	0.57	neutral	0.71	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	0.16	medium_impact	-3.28	low_impact	0.24	0.8	15.75	11.72	0.38	N	0.02	polymorphism	1	0.00	rs201144988	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	13982	13982	C	A	MI.22759	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1646	549	P	H	cCc/cAc	0.17	0.09	0	possibly_damaging	0.84	neutral	0.54	neutral	1.02	neutral	0.96	neutral	-1.05	neutral_impact	0	0.74	neutral	0.54	neutral	4.09	23.70	deleterious	0.32	0.5	0.67	disease	0.21	neutral	0.54	disease	0.48	neutral	0	0.82	neutral	0.35	neutral	-3	neutral	0.67	deleterious	-1.43	low_impact	0.27	medium_impact	-1.2	low_impact	0.36	0.8	15.75	11.72	0.3	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6091	6091	T	G	MI.2276	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	188	63	F	C	tTt/tGt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-2.08	deleterious	-4.38	high_impact	4.75	0.62	neutral	0.52	neutral	3.96	23.60	deleterious	0.22	0.55	0.59	disease	0.9	disease	0.6	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.30	0.9	1.95	6.88	0.67	P	0.91	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13982	13982	C	T	MI.22760	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1646	549	P	L	cCc/cTc	0.17	0.09	0	benign	0.05	neutral	0.94	neutral	1.17	neutral	3.44	neutral	-0.53	neutral_impact	-0.55	0.76	neutral	0.54	neutral	2.87	21.70	deleterious	0.29	0.45	0.27	neutral	0.24	neutral	0.4	neutral	0.41	neutral	2	0.01	neutral	0.95	deleterious	-6	neutral	0.30	neutral	0.47	medium_impact	0.89	medium_impact	-1.71	low_impact	0.75	0.85	15.75	11.72	0.32	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13982	13982	C	G	MI.22761	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1646	549	P	R	cCc/cGc	0.17	0.09	0	benign	0.23	neutral	0.31	neutral	1.01	neutral	0.77	neutral	-0.4	neutral_impact	0	0.71	neutral	0.5	neutral	2.17	17.28	deleterious	0.27	0.45	0.47	neutral	0.41	neutral	0.58	disease	0.47	neutral	1	0.63	neutral	0.54	deleterious	-6	neutral	0.51	deleterious	-0.25	medium_impact	0.04	medium_impact	-1.2	low_impact	0.50	0.8	15.75	11.72	0.41	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13984	13984	C	G	MI.22762	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1648	550	L	V	Cta/Gta	-2.12	0	0	possibly_damaging	0.44	neutral	0.55	neutral	0.97	neutral	-0.82	neutral	-0.1	low_impact	1.2	0.75	neutral	0.73	neutral	3.22	22.70	deleterious	0.42	0.55	0.36	neutral	0.16	neutral	0.41	neutral	0.33	neutral	3	0.42	neutral	0.56	deleterious	-3	neutral	0.51	deleterious	-0.65	medium_impact	0.28	medium_impact	-0.11	medium_impact	0.48	0.8	25.7	16.16	0.32	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13984	13984	C	A	MI.22763	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1648	550	L	M	Cta/Ata	-2.12	0	0	probably_damaging	0.93	neutral	0.24	neutral	0.95	neutral	-1.8	neutral	0.4	neutral_impact	0.4	0.82	neutral	0.85	neutral	3.88	23.50	deleterious	0.24	0.45	0.57	disease	0.17	neutral	0.27	neutral	0.36	neutral	3	0.95	neutral	0.16	neutral	-2	neutral	0.67	deleterious	-1.81	low_impact	-0.04	medium_impact	-0.84	medium_impact	0.49	0.8	25.7	16.16	0.44	N	0.53	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13985	13985	T	A	MI.22764	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1649	550	L	Q	cTa/cAa	-0.75	0	0	probably_damaging	0.9	neutral	0.37	neutral	1.02	neutral	0.38	neutral	0.51	low_impact	1.2	0.72	neutral	0.7	neutral	4.16	23.80	deleterious	0.21	0.45	0.69	disease	0.39	neutral	0.46	neutral	0.65	disease	3	0.91	neutral	0.24	neutral	-2	neutral	0.70	deleterious	-1.65	low_impact	0.11	medium_impact	-0.11	medium_impact	0.40	0.8	25.7	16.16	0.39	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13985	13985	T	C	MI.22765	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1649	550	L	P	cTa/cCa	-0.75	0	0	probably_damaging	0.9	neutral	0.23	neutral	0.96	neutral	-1.39	neutral	-0.18	low_impact	1.2	0.58	damaging	0.47	neutral	3.96	23.60	deleterious	0.15	0.4	0.69	disease	0.72	disease	0.62	disease	0.74	disease	5	0.93	neutral	0.17	neutral	-2	neutral	0.77	deleterious	-1.65	low_impact	-0.06	medium_impact	-0.11	medium_impact	0.56	0.8	25.7	16.16	0.37	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13985	13985	T	G	MI.22766	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1649	550	L	R	cTa/cGa	-0.75	0	0	possibly_damaging	0.87	neutral	0.4	neutral	1.01	neutral	0.21	neutral	-0.06	low_impact	1.2	0.68	neutral	0.55	neutral	4.22	23.90	deleterious	0.22	0.45	0.61	disease	0.66	disease	0.54	disease	0.71	disease	4	0.87	neutral	0.27	neutral	-3	neutral	0.72	deleterious	-1.53	low_impact	0.14	medium_impact	-0.11	medium_impact	0.61	0.8	25.7	16.16	0.33	N	0.67	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13987	13987	C	T	MI.22767	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1651	551	L	F	Ctc/Ttc	-12.44	0	0	benign	0.06	neutral	0.72	neutral	0.94	neutral	-2.47	neutral	-1.17	low_impact	1.25	0.82	neutral	0.84	neutral	2.13	17.05	deleterious	0.4	0.5	0.78	disease	0.24	neutral	0.31	neutral	0.59	disease	2	0.19	neutral	0.83	deleterious	-6	neutral	0.73	deleterious	0.39	medium_impact	0.46	medium_impact	-0.06	medium_impact	0.31	0.8	30.35	21.25	0.29	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13987	13987	C	G	MI.22768	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1651	551	L	V	Ctc/Gtc	-12.44	0	0	benign	0.33	neutral	0.51	neutral	0.97	neutral	-0.57	neutral	0	low_impact	1.8	0.81	neutral	0.78	neutral	1.84	15.21	deleterious	0.34	0.5	0.41	neutral	0.15	neutral	0.31	neutral	0.32	neutral	4	0.4	neutral	0.59	deleterious	-6	neutral	0.66	deleterious	-0.45	medium_impact	0.24	medium_impact	0.44	medium_impact	0.38	0.8	30.35	21.25	0.38	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13987	13987	C	A	MI.22769	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1651	551	L	I	Ctc/Atc	-12.44	0	0	benign	0.06	neutral	0.44	neutral	0.96	neutral	-0.91	neutral	-0.2	low_impact	0.9	0.8	neutral	0.76	neutral	2.67	20.60	deleterious	0.38	0.5	0.58	disease	0.16	neutral	0.29	neutral	0.36	neutral	3	0.51	neutral	0.69	deleterious	-6	neutral	0.69	deleterious	0.39	medium_impact	0.18	medium_impact	-0.38	medium_impact	0.40	0.8	30.35	21.25	0.37	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6092	6092	T	G	MI.2277	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	189	63	F	L	ttT/ttG	5.91	1	0	probably_damaging	0.99	neutral	0.19	neutral	2.95	neutral	1.58	deleterious	-2.79	low_impact	1.23	0.56	damaging	0.64	neutral	3.08	22.50	deleterious	0.44	0.55	0.18	neutral	0.61	disease	0.34	neutral	0.4	neutral	2	0.99	deleterious	0.1	neutral	-2	neutral	0.68	deleterious	-2.64	low_impact	-0.16	medium_impact	0.04	medium_impact	0.60	0.9	1.95	6.88	0.59	P	0.83	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13988	13988	T	C	MI.22770	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1652	551	L	P	cTc/cCc	-0.29	0	0	probably_damaging	0.93	neutral	0.21	neutral	0.95	neutral	-1.7	neutral	-1.25	low_impact	1.45	0.61	neutral	0.47	neutral	2.84	21.60	deleterious	0.15	0.4	0.58	disease	0.72	disease	0.65	disease	0.74	disease	5	0.95	neutral	0.14	neutral	-2	neutral	0.78	deleterious	-1.81	low_impact	-0.09	medium_impact	0.12	medium_impact	0.49	0.8	30.35	21.25	0.3	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13988	13988	T	G	MI.22771	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1652	551	L	R	cTc/cGc	-0.29	0	0	probably_damaging	0.91	neutral	0.36	neutral	1.03	neutral	0.5	neutral	-0.8	low_impact	1.25	0.75	neutral	0.74	neutral	2.84	21.60	deleterious	0.2	0.45	0.37	neutral	0.63	disease	0.44	neutral	0.49	neutral	0	0.91	neutral	0.23	neutral	-2	neutral	0.72	deleterious	-1.7	low_impact	0.1	medium_impact	-0.06	medium_impact	0.46	0.8	30.35	21.25	0.36	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13988	13988	T	A	MI.22772	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1652	551	L	H	cTc/cAc	-0.29	0	0	probably_damaging	0.97	neutral	0.54	neutral	1.02	neutral	0.27	neutral	-1.24	neutral_impact	-0.26	0.71	neutral	0.89	neutral	2.58	19.99	deleterious	0.22	0.45	0.32	neutral	0.13	neutral	0.16	neutral	0.28	neutral	4	0.96	neutral	0.29	neutral	-2	neutral	0.65	deleterious	-2.18	low_impact	0.27	medium_impact	-1.44	low_impact	0.35	0.8	30.35	21.25	0.38	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13990	13990	C	T	MI.22773	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1654	552	L	F	Ctc/Ttc	-3.04	0	0	probably_damaging	1	neutral	0.7	neutral	3.64	neutral	-1.99	deleterious	-2.51	medium_impact	2.71	0.72	neutral	0.16	damaging	4.16	23.80	deleterious	0.3	0.45	0.55	disease	0.34	neutral	0.54	disease	0.62	disease	2	1	deleterious	0.35	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.44	medium_impact	1.27	medium_impact	0.48	0.8	9.29	9.55	0.21	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13990	13990	C	A	MI.22774	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1654	552	L	I	Ctc/Atc	-3.04	0	0	probably_damaging	1	neutral	0.4	neutral	3.72	neutral	-0.92	neutral	-0.78	medium_impact	1.98	0.81	neutral	0.95	neutral	3.20	22.70	deleterious	0.31	0.45	0.51	disease	0.16	neutral	0.2	neutral	0.27	neutral	5	1	deleterious	0.2	neutral	1	deleterious	0.69	deleterious	-3.6	low_impact	0.14	medium_impact	0.61	medium_impact	0.41	0.8	9.29	9.55	0.43	N	0.85	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13990	13990	C	G	MI.22775	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1654	552	L	V	Ctc/Gtc	-3.04	0	0	probably_damaging	1	neutral	0.51	neutral	3.73	neutral	-0.38	neutral	-1.24	medium_impact	2.55	0.84	neutral	0.31	neutral	3.57	23.10	deleterious	0.33	0.5	0.5	neutral	0.19	neutral	0.26	neutral	0.31	neutral	4	1	deleterious	0.26	neutral	1	deleterious	0.69	deleterious	-3.6	low_impact	0.24	medium_impact	1.13	medium_impact	0.40	0.8	9.29	9.55	0.3	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13991	13991	T	C	MI.22776	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1655	552	L	P	cTc/cCc	-1.89	0	0	probably_damaging	1	neutral	0.21	neutral	3.6	deleterious	-3.1	deleterious	-4.25	high_impact	3.52	0.6	damaging	0.1	damaging	4.07	23.70	deleterious	0.13	0.4	0.85	disease	0.75	disease	0.71	disease	0.78	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.09	medium_impact	2.01	high_impact	0.42	0.8	9.29	9.55	0.25	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13991	13991	T	G	MI.22777	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1655	552	L	R	cTc/cGc	-1.89	0	0	probably_damaging	1	neutral	0.36	neutral	3.62	neutral	-2.16	deleterious	-3.73	high_impact	3.52	0.79	neutral	0.19	damaging	4.32	24.00	deleterious	0.18	0.45	0.56	disease	0.72	disease	0.7	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.1	medium_impact	2.01	high_impact	0.49	0.8	9.29	9.55	0.27	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13991	13991	T	A	MI.22778	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1655	552	L	H	cTc/cAc	-1.89	0	0	probably_damaging	1	neutral	0.54	neutral	3.61	neutral	-2.96	deleterious	-4.41	high_impact	3.52	0.73	neutral	0.16	damaging	4.31	24.00	deleterious	0.19	0.45	0.78	disease	0.6	disease	0.65	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.6	low_impact	0.27	medium_impact	2.01	high_impact	0.38	0.8	9.29	9.55	0.23	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13993	13993	C	A	MI.22779	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1657	553	L	M	Cta/Ata	-3.73	0	0	probably_damaging	1	neutral	0.24	neutral	0.79	neutral	-1.97	neutral	-0.66	neutral_impact	0.78	0.81	neutral	0.93	neutral	2.56	19.86	deleterious	0.3	0.45	0.74	disease	0.12	neutral	0.19	neutral	0.4	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	-0.04	medium_impact	-0.49	medium_impact	0.73	0.85	18.57	16.72	0.47	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6092	6092	T	A	MI.2278	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	189	63	F	L	ttT/ttA	5.91	1	0	probably_damaging	0.99	neutral	0.19	neutral	2.95	neutral	1.58	deleterious	-2.79	low_impact	1.23	0.56	damaging	0.64	neutral	3.21	22.70	deleterious	0.44	0.55	0.18	neutral	0.61	disease	0.34	neutral	0.4	neutral	2	0.99	deleterious	0.1	neutral	-2	neutral	0.68	deleterious	-2.64	low_impact	-0.16	medium_impact	0.04	medium_impact	0.60	0.9	1.95	6.88	0.59	P	0.83	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13993	13993	C	G	MI.22780	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1657	553	L	V	Cta/Gta	-3.73	0	0	probably_damaging	1	neutral	0.51	neutral	0.85	neutral	-1.1	neutral	-1.83	low_impact	1.04	0.77	neutral	0.46	neutral	1.71	14.47	neutral	0.37	0.5	0.43	neutral	0.06	neutral	0.19	neutral	0.27	neutral	5	1	deleterious	0.26	neutral	-2	neutral	0.65	deleterious	-3.6	low_impact	0.24	medium_impact	-0.25	medium_impact	0.51	0.8	18.57	16.72	0.36	N	0.62	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13994	13994	T	A	MI.22781	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1658	553	L	Q	cTa/cAa	-0.75	0	0	probably_damaging	1	neutral	0.35	neutral	0.74	deleterious	-3.76	deleterious	-4.37	medium_impact	2.67	0.73	neutral	0.13	damaging	4.25	23.90	deleterious	0.2	0.45	0.67	disease	0.47	neutral	0.57	disease	0.67	disease	3	1	deleterious	0.18	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.08	medium_impact	1.24	medium_impact	0.40	0.8	18.57	16.72	0.3	N	0.97	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13994	13994	T	G	MI.22782	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1658	553	L	R	cTa/cGa	-0.75	0	0	probably_damaging	1	neutral	0.34	neutral	0.74	deleterious	-3.6	deleterious	-4.57	medium_impact	2.67	0.66	neutral	0.11	damaging	4.34	24.00	deleterious	0.18	0.45	0.66	disease	0.67	disease	0.7	disease	0.75	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.07	medium_impact	1.24	medium_impact	0.53	0.8	18.57	16.72	0.24	N	0.96	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13994	13994	T	C	MI.22783	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1658	553	L	P	cTa/cCa	-0.75	0	0	probably_damaging	1	neutral	0.21	neutral	0.73	deleterious	-4.21	deleterious	-5.35	medium_impact	2.67	0.59	damaging	0.1	damaging	4.08	23.70	deleterious	0.15	0.45	0.83	disease	0.74	disease	0.71	disease	0.79	disease	6	1	deleterious	0.11	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	-0.09	medium_impact	1.24	medium_impact	0.39	0.8	18.57	16.72	0.21	N	0.89	disease_causing	0.56	0.21	.	.	.	.	.	endometrial and ovarian tumors	COSM6716769	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13996	13996	G	C	MI.22784	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1660	554	D	H	Gac/Cac	-2.58	0	0	probably_damaging	1	neutral	0.54	neutral	-0.7	deleterious	-7.83	deleterious	-6.18	high_impact	3.82	0.54	damaging	0.1	damaging	3.77	23.40	deleterious	0.32	0.5	0.83	disease	0.76	disease	0.83	disease	0.81	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.27	medium_impact	2.29	high_impact	0.56	0.8	26.37	7.08	0.35	N	0.99	disease_causing	0.92	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13996	13996	G	A	MI.22785	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1660	554	D	N	Gac/Aac	-2.58	0	0	probably_damaging	1	neutral	0.4	neutral	-0.66	deleterious	-5.96	deleterious	-4.41	medium_impact	3.48	0.46	damaging	0.11	damaging	4.37	24.10	deleterious	0.53	0.6	0.62	disease	0.66	disease	0.81	disease	0.75	disease	5	1	deleterious	0.2	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.14	medium_impact	1.98	medium_impact	0.70	0.85	26.37	7.08	0.42	N	0.98	disease_causing	0.7	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13996	13996	G	T	MI.22786	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1660	554	D	Y	Gac/Tac	-2.58	0	0	probably_damaging	1	neutral	1	neutral	-0.71	deleterious	-9.11	deleterious	-7.94	high_impact	3.82	0.54	damaging	0.1	damaging	4.07	23.70	deleterious	0.2	0.45	0.89	disease	0.8	disease	0.82	disease	0.85	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.83	deleterious	-3.6	low_impact	1.89	high_impact	2.29	high_impact	0.35	0.8	26.37	7.08	0.36	N	0.99	disease_causing	0.96	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13997	13997	A	C	MI.22787	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1661	554	D	A	gAc/gCc	8.88	1	0	probably_damaging	1	neutral	0.62	neutral	-0.68	deleterious	-6.76	deleterious	-7.06	medium_impact	3.48	0.55	damaging	0.12	damaging	3.79	23.40	deleterious	0.26	0.45	0.67	disease	0.66	disease	0.79	disease	0.76	disease	5	1	deleterious	0.31	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.35	medium_impact	1.98	medium_impact	0.48	0.8	26.37	7.08	0.53	P	0.94	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13997	13997	A	T	MI.22788	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1661	554	D	V	gAc/gTc	8.88	1	0	probably_damaging	1	neutral	0.56	neutral	-0.7	deleterious	-8.49	deleterious	-7.92	high_impact	3.82	0.48	damaging	0.12	damaging	3.88	23.50	deleterious	0.2	0.45	0.76	disease	0.74	disease	0.8	disease	0.79	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.80	deleterious	-3.6	low_impact	0.29	medium_impact	2.29	high_impact	0.36	0.8	26.37	7.08	0.55	P	0.99	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13997	13997	A	G	MI.22789	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1661	554	D	G	gAc/gGc	8.88	1	0	probably_damaging	1	neutral	0.39	neutral	-0.68	deleterious	-6.76	deleterious	-6.18	high_impact	3.82	0.5	damaging	0.13	damaging	4.10	23.70	deleterious	0.28	0.45	0.8	disease	0.65	disease	0.79	disease	0.76	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.13	medium_impact	2.29	high_impact	0.43	0.8	26.37	7.08	0.58	P	0.98	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6093	6093	G	A	MI.2279	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	190	64	V	M	Gta/Ata	-8.66	0	0	possibly_damaging	0.84	neutral	0.18	neutral	2.74	neutral	-1.71	neutral	-1.27	medium_impact	2.52	0.66	neutral	0.57	neutral	3.43	23.00	deleterious	0.44	0.55	0.61	disease	0.59	disease	0.36	neutral	0.5	neutral	0	0.91	neutral	0.17	neutral	0	NA	0.69	deleterious	-1.43	low_impact	-0.17	medium_impact	1.23	medium_impact	0.96	1	12.87	22.39	0.36	N	0.82	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13998	13998	C	G	MI.22790	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1662	554	D	E	gaC/gaG	8.42	1	0	probably_damaging	1	neutral	0.43	neutral	-0.6	deleterious	-4.78	deleterious	-3.53	medium_impact	2.03	0.5	damaging	0.19	damaging	4.07	23.70	deleterious	0.48	0.55	0.48	neutral	0.6	disease	0.71	disease	0.67	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.17	medium_impact	0.65	medium_impact	0.55	0.8	26.37	7.08	0.55	P	0.91	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13998	13998	C	A	MI.22791	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1662	554	D	E	gaC/gaA	8.42	1	0	probably_damaging	1	neutral	0.43	neutral	-0.6	deleterious	-4.78	deleterious	-3.53	medium_impact	2.03	0.5	damaging	0.19	damaging	4.40	24.10	deleterious	0.48	0.55	0.48	neutral	0.6	disease	0.71	disease	0.67	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.17	medium_impact	0.65	medium_impact	0.55	0.8	26.37	7.08	0.56	P	0.91	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	13999	13999	C	G	MI.22792	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1663	555	L	V	Cta/Gta	-2.58	0	0	possibly_damaging	0.79	neutral	0.51	neutral	0.88	neutral	-1.96	neutral	-1.67	medium_impact	2.47	0.75	neutral	0.64	neutral	2.28	18.06	deleterious	0.32	0.5	0.6	disease	0.26	neutral	0.36	neutral	0.57	disease	1	0.77	neutral	0.36	neutral	0	NA	0.72	deleterious	-1.29	low_impact	0.24	medium_impact	1.05	medium_impact	0.48	0.8	10.95	11.63	0.31	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	13999	13999	C	A	MI.22793	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1663	555	L	M	Cta/Ata	-2.58	0	0	probably_damaging	0.96	neutral	0.23	neutral	0.9	neutral	-1.53	neutral	-0.64	medium_impact	2.12	0.86	neutral	0.97	neutral	2.83	21.50	deleterious	0.29	0.45	0.61	disease	0.22	neutral	0.2	neutral	0.46	neutral	1	0.97	neutral	0.14	neutral	1	deleterious	0.70	deleterious	-2.06	low_impact	-0.06	medium_impact	0.73	medium_impact	0.70	0.85	10.95	11.63	0.52	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14000	14000	T	G	MI.22794	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1664	555	L	R	cTa/cGa	-5.56	0	0	probably_damaging	0.95	neutral	0.35	neutral	0.96	neutral	-0.47	deleterious	-3.38	medium_impact	2.47	0.78	neutral	0.75	neutral	3.14	22.60	deleterious	0.21	0.45	0.27	neutral	0.69	disease	0.47	neutral	0.53	disease	1	0.96	neutral	0.2	neutral	1	deleterious	0.72	deleterious	-1.96	low_impact	0.08	medium_impact	1.05	medium_impact	0.55	0.8	10.95	11.63	0.31	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14000	14000	T	A	MI.22795	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1664	555	L	Q	cTa/cAa	-5.56	0	0	probably_damaging	0.95	neutral	0.31	neutral	1.15	neutral	1.05	deleterious	-2.98	low_impact	1.06	0.83	neutral	0.87	neutral	1.99	16.14	deleterious	0.2	0.45	0.47	neutral	0.12	neutral	0.22	neutral	0.32	neutral	4	0.96	neutral	0.18	neutral	-2	neutral	0.68	deleterious	-1.96	low_impact	0.04	medium_impact	-0.23	medium_impact	0.48	0.8	10.95	11.63	0.36	N	0.75	polymorphism	1	0.06	rs28359185	Likely_benign	not_provided	237380	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14000	14000	T	C	MI.22796	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1664	555	L	P	cTa/cCa	-5.56	0	0	probably_damaging	0.96	neutral	0.21	neutral	0.87	neutral	-2.33	deleterious	-4.14	medium_impact	3.37	0.61	neutral	0.33	neutral	2.97	22.10	deleterious	0.15	0.4	0.62	disease	0.8	disease	0.57	disease	0.75	disease	5	0.98	neutral	0.13	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	-0.09	medium_impact	1.88	medium_impact	0.44	0.8	10.95	11.63	0.3	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14002	14002	A	T	MI.22797	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1666	556	T	S	Acc/Tcc	-1.67	0	0.02	benign	0.11	neutral	0.45	neutral	1	neutral	0.01	neutral	-1.64	neutral_impact	0.73	0.83	neutral	0.82	neutral	0.46	7.08	deleterious	0.41	0.5	0.39	neutral	0.15	neutral	0.24	neutral	0.31	neutral	4	0.48	neutral	0.67	deleterious	-6	neutral	0.31	neutral	0.12	medium_impact	0.18	medium_impact	-0.54	medium_impact	0.45	0.8	30.35	18.65	0.41	N	0.32	polymorphism	1	0.03	rs386829198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14002	14002	A	G	MI.22798	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1666	556	T	A	Acc/Gcc	-1.67	0	0.02	benign	0	neutral	0.59	neutral	0.89	neutral	-1.01	neutral	-1.46	low_impact	1.31	0.87	neutral	0.93	neutral	0.53	7.65	deleterious	0.51	0.6	0.38	neutral	0.2	neutral	0.29	neutral	0.38	neutral	2	0.4	neutral	0.8	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.32	medium_impact	-0.01	medium_impact	0.41	0.8	30.35	18.65	0.36	N	0.10	polymorphism	1	0.03	rs386829198	Likely_benign	not_provided	439239	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14002	14002	A	C	MI.22799	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1666	556	T	P	Acc/Ccc	-1.67	0	0.02	benign	0.41	neutral	0.21	neutral	0.79	deleterious	-3.69	deleterious	-2.98	medium_impact	2.81	0.59	damaging	0.33	neutral	3.22	22.70	deleterious	0.15	0.4	0.71	disease	0.71	disease	0.65	disease	0.72	disease	4	0.76	neutral	0.4	neutral	-3	neutral	0.63	deleterious	-0.6	medium_impact	-0.09	medium_impact	1.36	medium_impact	0.47	0.8	30.35	18.65	0.29	N	0.77	polymorphism	1	0.24	rs386829198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8633	8633	A	C	MI.228	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	107	36	Y	S	tAt/tCt	2.9	0.2	0	benign	0.08	neutral	0.37	neutral	4.51	neutral	2.68	neutral	-0.56	neutral_impact	-0.39	0.83	neutral	0.51	neutral	1.58	13.74	neutral	0.49	0.65	0.39	neutral	0.46	neutral	0.4	neutral	0.49	neutral	0	0.59	neutral	0.65	deleterious	-6	neutral	0.22	neutral	0.25	medium_impact	0.16	medium_impact	-1.43	low_impact	0.40	0.9	29.2	23.72	0.32	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6093	6093	G	C	MI.2280	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	190	64	V	L	Gta/Cta	-8.66	0	0	benign	0.04	neutral	0.32	neutral	2.94	neutral	0.01	neutral	-0.9	low_impact	0.88	0.66	neutral	0.53	neutral	0.22	4.91	deleterious	0.36	0.55	0.16	neutral	0.5	neutral	0.28	neutral	0.43	neutral	2	0.66	neutral	0.64	deleterious	-6	neutral	0.16	neutral	0.54	medium_impact	0.01	medium_impact	-0.29	medium_impact	0.62	0.9	12.87	22.39	0.43	N	0.55	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14003	14003	C	A	MI.22800	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1667	556	T	N	aCc/aAc	-0.52	0	0.01	benign	0.41	neutral	0.36	neutral	0.82	neutral	-2.34	deleterious	-2.54	low_impact	1.07	0.84	neutral	0.84	neutral	2.29	18.11	deleterious	0.39	0.5	0.49	neutral	0.46	neutral	0.29	neutral	0.45	neutral	1	0.58	neutral	0.48	deleterious	-6	neutral	0.54	deleterious	-0.6	medium_impact	0.1	medium_impact	-0.23	medium_impact	0.61	0.8	30.35	18.65	0.36	N	0.41	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14003	14003	C	G	MI.22801	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1667	556	T	S	aCc/aGc	-0.52	0	0.01	benign	0.11	neutral	0.45	neutral	1	neutral	0.01	neutral	-1.64	neutral_impact	0.73	0.83	neutral	0.82	neutral	0.65	8.46	deleterious	0.41	0.5	0.39	neutral	0.15	neutral	0.24	neutral	0.31	neutral	4	0.48	neutral	0.67	deleterious	-6	neutral	0.31	neutral	0.12	medium_impact	0.18	medium_impact	-0.54	medium_impact	0.45	0.8	30.35	18.65	0.38	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14003	14003	C	T	MI.22802	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1667	556	T	I	aCc/aTc	-0.52	0	0.01	benign	0	neutral	0.42	neutral	0.79	deleterious	-3.65	neutral	0.38	low_impact	1.31	0.85	neutral	0.96	neutral	0.37	6.36	deleterious	0.32	0.5	0.35	neutral	0.26	neutral	0.29	neutral	0.46	neutral	1	0.58	neutral	0.71	deleterious	-6	neutral	0.14	neutral	2.1	high_impact	0.16	medium_impact	-0.01	medium_impact	0.38	0.8	30.35	18.65	0.4	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14005	14005	T	G	MI.22803	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1669	557	W	G	Tga/Gga	-10.83	0	0	probably_damaging	1	neutral	0.39	neutral	-1.32	deleterious	-9.44	deleterious	-11.48	high_impact	3.72	0.64	neutral	0.13	damaging	4.11	23.70	deleterious	0.29	0.45	0.53	disease	0.67	disease	0.81	disease	0.75	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.74	deleterious	-3.6	low_impact	0.13	medium_impact	2.2	high_impact	0.21	0.8	15.75	7.29	0.34	N	0.97	polymorphism	0.97	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14005	14005	T	C	MI.22804	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1669	557	W	R	Tga/Cga	-10.83	0	0	probably_damaging	1	neutral	0.43	neutral	-1.32	deleterious	-9.4	deleterious	-12.36	high_impact	3.72	0.63	neutral	0.13	damaging	3.72	23.30	deleterious	0.29	0.45	0.64	disease	0.8	disease	0.85	disease	0.83	disease	7	1	deleterious	0.22	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.17	medium_impact	2.2	high_impact	0.27	0.8	15.75	7.29	0.37	N	0.97	polymorphism	0.99	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14006	14006	G	C	MI.22805	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1670	557	W	S	tGa/tCa	7.27	1	0	probably_damaging	1	neutral	0.53	neutral	-1.32	deleterious	-9.23	deleterious	-12.36	medium_impact	2.83	0.64	neutral	0.15	damaging	4.20	23.90	deleterious	0.29	0.45	0.45	neutral	0.74	disease	0.8	disease	0.78	disease	6	1	deleterious	0.27	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.26	medium_impact	1.38	medium_impact	0.19	0.8	15.75	7.29	0.39	N	0.95	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14006	14006	G	T	MI.22806	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1670	557	W	L	tGa/tTa	7.27	1	0	probably_damaging	1	neutral	0.7	neutral	-1.27	deleterious	-6.71	deleterious	-11.48	medium_impact	2.48	0.63	neutral	0.19	damaging	4.39	24.10	deleterious	0.23	0.45	0.41	neutral	0.68	disease	0.77	disease	0.62	disease	2	1	deleterious	0.35	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.44	medium_impact	1.06	medium_impact	0.22	0.8	15.75	7.29	0.4	N	0.97	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14007	14007	A	C	MI.22807	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1671	557	W	C	tgA/tgC	7.27	1	0	probably_damaging	1	neutral	0.18	neutral	-1.32	deleterious	-10.73	deleterious	-11.48	high_impact	3.72	0.6	damaging	0.1	damaging	4.17	23.80	deleterious	0.27	0.45	0.83	disease	0.71	disease	0.84	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	-0.13	medium_impact	2.2	high_impact	0.23	0.8	15.75	7.29	0.48	N	0.98	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14007	14007	A	T	MI.22808	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1671	557	W	C	tgA/tgT	7.27	1	0	probably_damaging	1	neutral	0.18	neutral	-1.32	deleterious	-10.73	deleterious	-11.48	high_impact	3.72	0.6	damaging	0.1	damaging	4.29	24.00	deleterious	0.27	0.45	0.83	disease	0.71	disease	0.84	disease	0.82	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	-0.13	medium_impact	2.2	high_impact	0.23	0.8	15.75	7.29	0.48	N	0.98	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14008	14008	C	G	MI.22809	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1672	558	L	V	Cta/Gta	1.54	0.8	0	probably_damaging	0.92	neutral	0.52	neutral	0.86	neutral	-1.07	neutral	-2.31	medium_impact	2.46	0.76	neutral	0.26	damaging	3.62	23.20	deleterious	0.33	0.5	0.32	neutral	0.26	neutral	0.54	disease	0.48	neutral	0	0.92	neutral	0.3	neutral	1	deleterious	0.68	deleterious	-1.75	low_impact	0.25	medium_impact	1.04	medium_impact	0.56	0.8	18.91	16.9	0.28	N	0.55	polymorphism	0.93	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6093	6093	G	T	MI.2281	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	190	64	V	L	Gta/Tta	-8.66	0	0	benign	0.04	neutral	0.32	neutral	2.94	neutral	0.01	neutral	-0.9	low_impact	0.88	0.66	neutral	0.53	neutral	0.38	6.48	deleterious	0.36	0.55	0.16	neutral	0.5	neutral	0.28	neutral	0.43	neutral	2	0.66	neutral	0.64	deleterious	-6	neutral	0.16	neutral	0.54	medium_impact	0.01	medium_impact	-0.29	medium_impact	0.62	0.9	12.87	22.39	0.43	N	0.55	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14008	14008	C	A	MI.22810	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1672	558	L	M	Cta/Ata	1.54	0.8	0	probably_damaging	0.99	neutral	0.25	neutral	0.81	neutral	-1.76	neutral	-1.5	low_impact	1.26	0.8	neutral	0.93	neutral	2.79	21.30	deleterious	0.25	0.45	0.6	disease	0.21	neutral	0.23	neutral	0.46	neutral	1	0.99	deleterious	0.13	neutral	-2	neutral	0.71	deleterious	-2.64	low_impact	-0.03	medium_impact	-0.05	medium_impact	0.64	0.8	18.91	16.9	0.34	N	0.63	polymorphism	0.94	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14009	14009	T	A	MI.22811	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1673	558	L	Q	cTa/cAa	-1.21	0	0	probably_damaging	1	neutral	0.37	neutral	0.79	neutral	-2.29	deleterious	-4.76	medium_impact	2.65	0.74	neutral	0.17	damaging	4.54	24.30	deleterious	0.16	0.45	0.7	disease	0.55	disease	0.57	disease	0.64	disease	3	1	deleterious	0.19	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.11	medium_impact	1.22	medium_impact	0.50	0.8	18.91	16.9	0.28	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14009	14009	T	G	MI.22812	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1673	558	L	R	cTa/cGa	-1.21	0	0	probably_damaging	0.99	neutral	0.37	neutral	0.76	deleterious	-3.18	deleterious	-4.78	medium_impact	3	0.64	neutral	0.12	damaging	4.39	24.10	deleterious	0.12	0.4	0.8	disease	0.73	disease	0.69	disease	0.76	disease	5	0.99	deleterious	0.19	neutral	1	deleterious	0.85	deleterious	-2.64	low_impact	0.11	medium_impact	1.54	medium_impact	0.51	0.8	18.91	16.9	0.22	N	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14009	14009	T	C	MI.22813	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1673	558	L	P	cTa/cCa	-1.21	0	0	probably_damaging	1	neutral	0.23	neutral	0.75	deleterious	-4.02	deleterious	-5.6	medium_impact	3	0.58	damaging	0.11	damaging	4.11	23.70	deleterious	0.12	0.4	0.86	disease	0.74	disease	0.71	disease	0.78	disease	6	1	deleterious	0.12	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	-0.06	medium_impact	1.54	medium_impact	0.48	0.8	18.91	16.9	0.23	N	0.91	polymorphism	0.92	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14011	14011	G	C	MI.22814	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1675	559	E	Q	Gaa/Caa	-3.73	0	0	probably_damaging	0.91	neutral	0.36	neutral	-0.25	deleterious	-5.57	deleterious	-2.65	medium_impact	3.48	0.63	neutral	0.56	neutral	3.11	22.50	deleterious	0.34	0.5	0.58	disease	0.62	disease	0.57	disease	0.58	disease	2	0.92	neutral	0.23	neutral	1	deleterious	0.66	deleterious	-1.7	low_impact	0.1	medium_impact	1.98	medium_impact	0.60	0.8	27.86	7.1	0.36	N	0.77	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14011	14011	G	A	MI.22815	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1675	559	E	K	Gaa/Aaa	-3.73	0	0	benign	0.22	neutral	0.45	neutral	-0.18	deleterious	-4.14	deleterious	-3.53	medium_impact	2.15	0.6	damaging	0.54	neutral	2.71	20.90	deleterious	0.37	0.5	0.5	neutral	0.56	disease	0.51	disease	0.44	neutral	1	0.46	neutral	0.62	deleterious	-3	neutral	0.28	neutral	-0.22	medium_impact	0.18	medium_impact	0.76	medium_impact	0.62	0.8	27.86	7.1	0.33	N	0.35	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14012	14012	A	C	MI.22816	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1676	559	E	A	gAa/gCa	5.9	1	0	possibly_damaging	0.86	neutral	0.61	neutral	-0.26	deleterious	-5.68	deleterious	-5.3	high_impact	3.82	0.61	neutral	0.61	neutral	2.11	16.90	deleterious	0.25	0.45	0.62	disease	0.56	disease	0.66	disease	0.66	disease	3	0.83	neutral	0.38	neutral	1	deleterious	0.63	deleterious	-1.5	low_impact	0.34	medium_impact	2.29	high_impact	0.66	0.8	27.86	7.1	0.59	P	0.74	disease_causing	0.97	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14012	14012	A	T	MI.22817	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1676	559	E	V	gAa/gTa	5.9	1	0	probably_damaging	0.97	neutral	0.56	neutral	-0.28	deleterious	-7.1	deleterious	-6.18	high_impact	3.82	0.59	damaging	0.57	neutral	4.01	23.60	deleterious	0.21	0.45	0.73	disease	0.72	disease	0.67	disease	0.68	disease	4	0.97	neutral	0.3	neutral	2	deleterious	0.76	deleterious	-2.18	low_impact	0.29	medium_impact	2.29	high_impact	0.70	0.85	27.86	7.1	0.51	P	0.91	disease_causing	0.99	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14012	14012	A	G	MI.22818	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1676	559	E	G	gAa/gGa	5.9	1	0	probably_damaging	0.94	neutral	0.36	neutral	-0.27	deleterious	-6.11	deleterious	-6.18	medium_impact	3.48	0.59	damaging	0.64	neutral	3.93	23.50	deleterious	0.29	0.45	0.7	disease	0.62	disease	0.65	disease	0.66	disease	3	0.94	neutral	0.21	neutral	1	deleterious	0.70	deleterious	-1.88	low_impact	0.1	medium_impact	1.98	medium_impact	0.42	0.8	27.86	7.1	0.54	P	0.82	disease_causing	0.97	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14013	14013	A	C	MI.22819	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1677	559	E	D	gaA/gaC	8.42	1	0	possibly_damaging	0.89	neutral	0.26	neutral	-0.21	deleterious	-4.58	deleterious	-2.65	medium_impact	3.48	0.6	damaging	0.52	neutral	3.46	23.00	deleterious	0.38	0.5	0.31	neutral	0.62	disease	0.5	neutral	0.49	neutral	0	0.92	neutral	0.19	neutral	0	NA	0.61	deleterious	-1.61	low_impact	-0.02	medium_impact	1.98	medium_impact	0.65	0.8	27.86	7.1	0.65	P	0.80	disease_causing	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6094	6094	T	A	MI.2282	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	191	64	V	E	gTa/gAa	1.51	0.97	0	probably_damaging	0.98	deleterious	0.01	neutral	2.68	deleterious	-3.38	deleterious	-3.59	high_impact	3.77	0.61	neutral	0.49	neutral	4.39	24.10	deleterious	0.11	0.55	0.79	disease	0.88	disease	0.7	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.35	low_impact	-0.92	medium_impact	2.38	high_impact	0.50	0.9	12.87	22.39	0.46	N	0.84	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14013	14013	A	T	MI.22820	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1677	559	E	D	gaA/gaT	8.42	1	0	possibly_damaging	0.89	neutral	0.26	neutral	-0.21	deleterious	-4.58	deleterious	-2.65	medium_impact	3.48	0.6	damaging	0.52	neutral	3.60	23.20	deleterious	0.38	0.5	0.31	neutral	0.62	disease	0.5	neutral	0.49	neutral	0	0.92	neutral	0.19	neutral	0	NA	0.61	deleterious	-1.61	low_impact	-0.02	medium_impact	1.98	medium_impact	0.65	0.8	27.86	7.1	0.66	P	0.80	disease_causing	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14014	14014	A	G	MI.22821	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1678	560	K	E	Aag/Gag	3.15	0.99	0	probably_damaging	1	neutral	0.34	neutral	0.82	neutral	-2.29	deleterious	-2.91	medium_impact	3.25	0.73	neutral	0.34	neutral	4.05	23.70	deleterious	0.4	0.5	0.38	neutral	0.73	disease	0.57	disease	0.63	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.07	medium_impact	1.77	medium_impact	0.70	0.85	17.25	18.6	0.46	N	0.77	disease_causing	0.75	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14014	14014	A	C	MI.22822	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1678	560	K	Q	Aag/Cag	3.15	0.99	0	probably_damaging	1	neutral	0.36	neutral	0.82	neutral	-2.18	deleterious	-2.89	medium_impact	3.05	0.76	neutral	0.37	neutral	3.43	23.00	deleterious	0.46	0.55	0.54	disease	0.62	disease	0.54	disease	0.59	disease	2	1	deleterious	0.18	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.1	medium_impact	1.58	medium_impact	0.64	0.8	17.25	18.6	0.45	N	0.74	disease_causing	0.65	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14015	14015	A	C	MI.22823	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1679	560	K	T	aAg/aCg	1.08	0.47	0	probably_damaging	1	neutral	0.45	neutral	0.84	neutral	-1.7	deleterious	-4.18	medium_impact	2.21	0.84	neutral	0.96	neutral	2.48	19.32	deleterious	0.29	0.45	0.43	neutral	0.52	disease	0.35	neutral	0.47	neutral	1	1	deleterious	0.23	neutral	1	deleterious	0.71	deleterious	-3.6	low_impact	0.18	medium_impact	0.82	medium_impact	0.63	0.8	17.25	18.6	0.31	N	0.77	polymorphism	0.64	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14015	14015	A	T	MI.22824	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1679	560	K	M	aAg/aTg	1.08	0.47	0	probably_damaging	1	neutral	0.28	neutral	0.82	neutral	-2.34	deleterious	-4.5	medium_impact	3.25	0.8	neutral	0.82	neutral	2.91	21.90	deleterious	0.28	0.45	0.7	disease	0.59	disease	0.43	neutral	0.53	disease	1	1	deleterious	0.14	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.01	medium_impact	1.77	medium_impact	0.48	0.8	17.25	18.6	0.33	N	0.83	disease_causing	0.56	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14016	14016	G	C	MI.22825	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1680	560	K	N	aaG/aaC	0.63	0.06	0.02	probably_damaging	1	neutral	0.37	neutral	0.86	neutral	-1.34	deleterious	-3.02	medium_impact	2.08	0.82	neutral	0.98	neutral	2.77	21.20	deleterious	0.56	0.6	0.51	disease	0.45	neutral	0.33	neutral	0.27	neutral	5	1	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.11	medium_impact	0.7	medium_impact	0.74	0.85	17.25	18.6	0.4	N	0.55	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14016	14016	G	T	MI.22826	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1680	560	K	N	aaG/aaT	0.63	0.06	0.02	probably_damaging	1	neutral	0.37	neutral	0.86	neutral	-1.34	deleterious	-3.02	medium_impact	2.08	0.82	neutral	0.98	neutral	2.91	21.90	deleterious	0.56	0.6	0.51	disease	0.45	neutral	0.33	neutral	0.27	neutral	5	1	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.11	medium_impact	0.7	medium_impact	0.74	0.85	17.25	18.6	0.4	N	0.55	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14017	14017	C	A	MI.22827	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1681	561	L	M	Cta/Ata	-2.35	0	0	possibly_damaging	0.9	neutral	0.23	neutral	0.91	neutral	-0.65	neutral	-0.05	neutral_impact	0.34	0.81	neutral	0.97	neutral	2.68	20.70	deleterious	0.35	0.5	0.49	neutral	0.07	neutral	0.17	neutral	0.26	neutral	5	0.93	neutral	0.17	neutral	-3	neutral	0.64	deleterious	-1.65	low_impact	-0.06	medium_impact	-0.89	medium_impact	0.77	0.85	27.53	21.87	0.59	P	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14017	14017	C	G	MI.22828	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1681	561	L	V	Cta/Gta	-2.35	0	0	benign	0.27	neutral	0.52	neutral	0.94	neutral	-0.38	neutral	0.36	neutral_impact	0.75	0.84	neutral	0.98	neutral	0.85	9.76	deleterious	0.35	0.5	0.34	neutral	0.07	neutral	0.14	neutral	0.31	neutral	4	0.38	neutral	0.63	deleterious	-6	neutral	0.49	deleterious	-0.34	medium_impact	0.25	medium_impact	-0.52	medium_impact	0.56	0.8	27.53	21.87	0.48	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14018	14018	T	G	MI.22829	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1682	561	L	R	cTa/cGa	-7.62	0	0	possibly_damaging	0.66	neutral	0.37	neutral	0.77	deleterious	-3.48	neutral	-1.77	medium_impact	2.13	0.74	neutral	0.5	neutral	4.26	23.90	deleterious	0.23	0.45	0.66	disease	0.54	disease	0.51	disease	0.56	disease	1	0.7	neutral	0.36	neutral	0	NA	0.74	deleterious	-1.02	low_impact	0.11	medium_impact	0.74	medium_impact	0.53	0.8	27.53	21.87	0.28	N	0.49	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6094	6094	T	G	MI.2283	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	191	64	V	G	gTa/gGa	1.51	0.97	0	probably_damaging	0.99	deleterious	0	neutral	2.69	deleterious	-3.18	deleterious	-4.23	high_impact	4.12	0.63	neutral	0.6	neutral	3.58	23.20	deleterious	0.17	0.55	0.58	disease	0.79	disease	0.59	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	2.71	high_impact	0.52	0.9	12.87	22.39	0.45	N	0.71	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14018	14018	T	C	MI.22830	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1682	561	L	P	cTa/cCa	-7.62	0	0	possibly_damaging	0.66	neutral	0.23	neutral	0.76	deleterious	-4.05	neutral	-1.84	medium_impact	2.13	0.64	neutral	0.41	neutral	2.89	21.80	deleterious	0.18	0.45	0.84	disease	0.65	disease	0.55	disease	0.7	disease	4	0.8	neutral	0.29	neutral	0	NA	0.81	deleterious	-1.02	low_impact	-0.06	medium_impact	0.74	medium_impact	0.48	0.8	27.53	21.87	0.3	N	0.68	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14018	14018	T	A	MI.22831	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1682	561	L	Q	cTa/cAa	-7.62	0	0	possibly_damaging	0.66	neutral	0.33	neutral	0.77	deleterious	-3.66	neutral	-1.47	medium_impact	2.13	0.81	neutral	0.6	neutral	4.18	23.80	deleterious	0.22	0.45	0.8	disease	0.34	neutral	0.38	neutral	0.62	disease	2	0.73	neutral	0.34	neutral	0	NA	0.73	deleterious	-1.02	low_impact	0.06	medium_impact	0.74	medium_impact	0.48	0.8	27.53	21.87	0.32	N	0.46	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14020	14020	T	G	MI.22832	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1684	562	L	V	Tta/Gta	-20	0	0	possibly_damaging	0.44	neutral	0.57	neutral	0.99	neutral	-0.19	neutral	-0.3	low_impact	1.2	0.78	neutral	0.66	neutral	0.39	6.56	deleterious	0.55	0.6	0.32	neutral	0.39	neutral	0.54	disease	0.45	neutral	1	0.41	neutral	0.57	deleterious	-3	neutral	0.45	deleterious	-0.65	medium_impact	0.3	medium_impact	-0.11	medium_impact	0.44	0.8	32.17	26.19	0.28	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14020	14020	T	A	MI.22833	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1684	562	L	M	Tta/Ata	-20	0	0	benign	0.06	neutral	0.3	neutral	0.96	neutral	-0.82	neutral	-0.24	neutral_impact	0.16	0.83	neutral	0.88	neutral	0.47	7.20	deleterious	0.41	0.5	0.64	disease	0.3	neutral	0.22	neutral	0.6	disease	2	0.67	neutral	0.62	deleterious	-6	neutral	0.28	neutral	0.39	medium_impact	0.03	medium_impact	-1.06	low_impact	0.69	0.85	32.17	26.19	0.4	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14021	14021	T	G	MI.22834	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1685	562	L	W	tTa/tGa	-0.06	0	0	probably_damaging	0.97	neutral	0.23	neutral	0.92	neutral	-2.47	deleterious	-3.64	low_impact	1.2	0.68	neutral	0.46	neutral	3.81	23.40	deleterious	0.21	0.45	0.9	disease	0.7	disease	0.59	disease	0.79	disease	6	0.98	neutral	0.13	neutral	-2	neutral	0.84	deleterious	-2.18	low_impact	-0.06	medium_impact	-0.11	medium_impact	0.54	0.8	32.17	26.19	0.27	N	0.61	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14021	14021	T	C	MI.22835	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1685	562	L	S	tTa/tCa	-0.06	0	0	possibly_damaging	0.71	neutral	0.53	neutral	1	neutral	-0.07	deleterious	-2.63	neutral_impact	0.57	0.7	neutral	0.81	neutral	3.63	23.20	deleterious	0.34	0.5	0.63	disease	0.5	neutral	0.57	disease	0.66	disease	3	0.68	neutral	0.41	neutral	-3	neutral	0.67	deleterious	-1.12	low_impact	0.26	medium_impact	-0.68	medium_impact	0.59	0.8	32.17	26.19	0.26	N	0.35	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14022	14022	A	T	MI.22836	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1686	562	L	F	ttA/ttT	2.92	0.21	0	possibly_damaging	0.69	neutral	0.71	neutral	0.94	neutral	-1.49	neutral	-2.02	low_impact	1.2	0.64	neutral	0.55	neutral	2.10	16.84	deleterious	0.48	0.55	0.63	disease	0.51	disease	0.55	disease	0.67	disease	3	0.62	neutral	0.51	deleterious	-3	neutral	0.66	deleterious	-1.08	low_impact	0.45	medium_impact	-0.11	medium_impact	0.56	0.8	32.17	26.19	0.28	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14022	14022	A	C	MI.22837	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1686	562	L	F	ttA/ttC	2.92	0.21	0	possibly_damaging	0.69	neutral	0.71	neutral	0.94	neutral	-1.49	neutral	-2.02	low_impact	1.2	0.64	neutral	0.55	neutral	1.96	15.97	deleterious	0.48	0.55	0.63	disease	0.51	disease	0.55	disease	0.67	disease	3	0.62	neutral	0.51	deleterious	-3	neutral	0.66	deleterious	-1.08	low_impact	0.45	medium_impact	-0.11	medium_impact	0.56	0.8	32.17	26.19	0.28	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14023	14023	C	A	MI.22838	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1687	563	P	T	Cct/Act	-4.87	0	0	probably_damaging	1	neutral	0.4	neutral	0.56	deleterious	-3.46	deleterious	-7.05	medium_impact	3.34	0.58	damaging	0.06	damaging	3.88	23.50	deleterious	0.39	0.5	0.54	disease	0.71	disease	0.72	disease	0.72	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.14	medium_impact	1.85	medium_impact	0.65	0.8	29.35	7.05	0.22	N	0.91	polymorphism	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14023	14023	C	G	MI.22839	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1687	563	P	A	Cct/Gct	-4.87	0	0	probably_damaging	1	neutral	0.51	neutral	0.67	neutral	-1.72	deleterious	-7.05	medium_impact	3.08	0.55	damaging	0.12	damaging	3.24	22.80	deleterious	0.41	0.5	0.52	disease	0.51	disease	0.66	disease	0.49	neutral	0	1	deleterious	0.26	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.24	medium_impact	1.61	medium_impact	0.68	0.85	29.35	7.05	0.24	N	0.73	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6094	6094	T	C	MI.2284	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	191	64	V	A	gTa/gCa	1.51	0.97	0	possibly_damaging	0.58	deleterious	0	neutral	2.8	neutral	-1.23	neutral	-2.34	medium_impact	2.8	0.67	neutral	0.6	neutral	3.10	22.50	deleterious	0.29	0.55	0.52	disease	0.58	disease	0.57	disease	0.69	disease	4	1	deleterious	0.21	neutral	4	deleterious	0.45	deleterious	-0.89	medium_impact	-1.48	low_impact	1.49	medium_impact	0.58	0.9	12.87	22.39	0.44	N	0.47	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14023	14023	C	T	MI.22840	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1687	563	P	S	Cct/Tct	-4.87	0	0	probably_damaging	1	neutral	0.41	neutral	0.64	neutral	-2.09	deleterious	-7.05	medium_impact	3.34	0.57	damaging	0.08	damaging	4.07	23.70	deleterious	0.49	0.55	0.48	neutral	0.72	disease	0.7	disease	0.72	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.15	medium_impact	1.85	medium_impact	0.21	0.8	29.35	7.05	0.22	N	0.78	polymorphism	0.97	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14024	14024	C	G	MI.22841	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1688	563	P	R	cCt/cGt	7.04	1	0	probably_damaging	1	neutral	0.35	neutral	0.53	deleterious	-4.51	deleterious	-7.94	medium_impact	3.19	0.54	damaging	0.09	damaging	3.70	23.30	deleterious	0.44	0.55	0.45	neutral	0.8	disease	0.79	disease	0.74	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.79	deleterious	-3.6	low_impact	0.08	medium_impact	1.71	medium_impact	0.67	0.85	29.35	7.05	0.49	P	0.64	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14024	14024	C	T	MI.22842	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1688	563	P	L	cCt/cTt	7.04	1	0	probably_damaging	1	neutral	0.66	neutral	0.53	deleterious	-4.29	deleterious	-8.81	high_impact	3.88	0.56	damaging	0.06	damaging	4.43	24.20	deleterious	0.39	0.5	0.65	disease	0.78	disease	0.7	disease	0.72	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.39	medium_impact	2.34	high_impact	0.80	0.85	29.35	7.05	0.47	N	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14024	14024	C	A	MI.22843	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1688	563	P	H	cCt/cAt	7.04	1	0	probably_damaging	1	neutral	0.54	neutral	0.52	deleterious	-5.52	deleterious	-7.94	high_impact	3.88	0.59	damaging	0.07	damaging	4.21	23.90	deleterious	0.46	0.55	0.75	disease	0.79	disease	0.77	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.27	medium_impact	2.34	high_impact	0.70	0.85	29.35	7.05	0.54	P	0.72	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14026	14026	A	C	MI.22844	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1690	564	K	Q	Aaa/Caa	-6.94	0	0	probably_damaging	1	neutral	0.31	neutral	0.99	neutral	-0.05	deleterious	-3.53	medium_impact	2.1	0.73	neutral	0.59	neutral	3.51	23.10	deleterious	0.63	0.7	0.4	neutral	0.61	disease	0.34	neutral	0.45	neutral	1	1	deleterious	0.16	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	0.04	medium_impact	0.72	medium_impact	0.68	0.85	9.62	6.96	0.38	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14026	14026	A	G	MI.22845	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1690	564	K	E	Aaa/Gaa	-6.94	0	0	probably_damaging	1	neutral	0.3	neutral	0.83	neutral	-1.1	deleterious	-3.53	medium_impact	2.21	0.7	neutral	0.67	neutral	4.17	23.80	deleterious	0.39	0.5	0.42	neutral	0.64	disease	0.48	neutral	0.46	neutral	1	1	deleterious	0.15	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.03	medium_impact	0.82	medium_impact	0.55	0.8	9.62	6.96	0.32	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14027	14027	A	T	MI.22846	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1691	564	K	M	aAa/aTa	4.06	0.99	0	probably_damaging	1	neutral	0.23	neutral	0.69	deleterious	-4.44	deleterious	-5.26	medium_impact	2.46	0.79	neutral	0.74	neutral	4.15	23.80	deleterious	0.3	0.45	0.67	disease	0.68	disease	0.54	disease	0.56	disease	1	1	deleterious	0.12	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.06	medium_impact	1.04	medium_impact	0.43	0.8	9.62	6.96	0.43	N	0.40	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14027	14027	A	C	MI.22847	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1691	564	K	T	aAa/aCa	4.06	0.99	0	probably_damaging	1	neutral	0.42	neutral	0.74	neutral	-2.32	deleterious	-5.3	medium_impact	2.63	0.74	neutral	0.7	neutral	3.82	23.40	deleterious	0.32	0.5	0.58	disease	0.67	disease	0.64	disease	0.62	disease	2	1	deleterious	0.21	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.16	medium_impact	1.2	medium_impact	0.54	0.8	9.62	6.96	0.44	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14028	14028	A	T	MI.22848	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1692	564	K	N	aaA/aaT	4.29	0.99	0	probably_damaging	1	neutral	0.32	neutral	0.74	neutral	-2.3	deleterious	-4.42	medium_impact	2.8	0.79	neutral	0.68	neutral	4.03	23.60	deleterious	0.65	0.7	0.62	disease	0.69	disease	0.65	disease	0.63	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.05	medium_impact	1.36	medium_impact	0.81	0.85	9.62	6.96	0.47	N	0.63	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14028	14028	A	C	MI.22849	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1692	564	K	N	aaA/aaC	4.29	0.99	0	probably_damaging	1	neutral	0.32	neutral	0.74	neutral	-2.3	deleterious	-4.42	medium_impact	2.8	0.79	neutral	0.68	neutral	3.98	23.60	deleterious	0.65	0.7	0.62	disease	0.69	disease	0.65	disease	0.63	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.05	medium_impact	1.36	medium_impact	0.81	0.85	9.62	6.96	0.44	N	0.63	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6096	6096	A	G	MI.2285	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	193	65	M	V	Ata/Gta	-4.5	0	0	probably_damaging	0.94	deleterious	0	neutral	2.53	neutral	-1.47	deleterious	-2.55	high_impact	4.83	0.5	damaging	0.13	damaging	2.64	20.50	deleterious	0.41	0.55	0.74	disease	0.9	disease	0.73	disease	0.79	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.83	deleterious	-1.88	low_impact	-1.48	low_impact	3.36	high_impact	0.33	0.9	3.12	7.58	0.67	P	0.88	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14029	14029	A	T	MI.22850	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1693	565	T	S	Aca/Tca	-0.06	0	0	benign	0.36	neutral	0.47	neutral	1.02	neutral	0.34	neutral	0.12	neutral_impact	0	0.84	neutral	0.99	neutral	-0.27	0.78	neutral	0.53	0.6	0.32	neutral	0.14	neutral	0.21	neutral	0.31	neutral	4	0.45	neutral	0.56	deleterious	-6	neutral	0.48	deleterious	-0.51	medium_impact	0.2	medium_impact	-1.2	low_impact	0.72	0.85	32.17	20.58	0.45	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14029	14029	A	C	MI.22851	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1693	565	T	P	Aca/Cca	-0.06	0	0	possibly_damaging	0.75	neutral	0.26	neutral	0.94	neutral	-1.88	neutral	-2.22	low_impact	1.15	0.78	neutral	0.37	neutral	3.44	23.00	deleterious	0.17	0.45	0.51	disease	0.66	disease	0.67	disease	0.74	disease	5	0.83	neutral	0.26	neutral	-3	neutral	0.74	deleterious	-1.2	low_impact	-0.02	medium_impact	-0.15	medium_impact	0.59	0.8	32.17	20.58	0.25	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14029	14029	A	G	MI.22852	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1693	565	T	A	Aca/Gca	-0.06	0	0	benign	0.01	neutral	0.53	neutral	1.04	neutral	0.54	neutral	-1.13	neutral_impact	0.05	0.86	neutral	0.87	neutral	-0.19	1.17	neutral	0.65	0.7	0.46	neutral	0.07	neutral	0.2	neutral	0.3	neutral	4	0.45	neutral	0.76	deleterious	-6	neutral	0.16	neutral	1.15	medium_impact	0.26	medium_impact	-1.16	low_impact	0.49	0.8	32.17	20.58	0.39	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14030	14030	C	A	MI.22853	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1694	565	T	K	aCa/aAa	-0.52	0	0	possibly_damaging	0.56	neutral	0.32	neutral	1.01	neutral	0.1	neutral	-1.37	low_impact	1.15	0.73	neutral	0.45	neutral	4.31	24.00	deleterious	0.3	0.45	0.42	neutral	0.42	neutral	0.64	disease	0.5	neutral	0	0.68	neutral	0.38	neutral	-3	neutral	0.62	deleterious	-0.85	medium_impact	0.05	medium_impact	-0.15	medium_impact	0.77	0.85	32.17	20.58	0.36	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14030	14030	C	T	MI.22854	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1694	565	T	M	aCa/aTa	-0.52	0	0	benign	0.08	neutral	0.27	neutral	0.97	neutral	-0.8	neutral	-1.38	neutral_impact	-0.24	0.86	neutral	0.77	neutral	2.75	21.10	deleterious	0.36	0.5	0.78	disease	0.22	neutral	0.24	neutral	0.53	disease	1	0.7	neutral	0.6	deleterious	-6	neutral	0.72	deleterious	0.26	medium_impact	-0.01	medium_impact	-1.42	low_impact	0.73	0.85	32.17	20.58	0.4	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14032	14032	A	G	MI.22855	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1696	566	I	V	Att/Gtt	-4.42	0	0	benign	0.09	neutral	0.52	neutral	0.87	neutral	-0.9	neutral	-0.48	low_impact	1.23	0.85	neutral	0.93	neutral	1.61	13.92	neutral	0.71	0.75	0.33	neutral	0.1	neutral	0.31	neutral	0.31	neutral	4	0.4	neutral	0.72	deleterious	-6	neutral	0.62	deleterious	0.21	medium_impact	0.25	medium_impact	-0.08	medium_impact	0.40	0.8	25.37	16.95	0.4	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14032	14032	A	T	MI.22856	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1696	566	I	F	Att/Ttt	-4.42	0	0	probably_damaging	0.91	neutral	0.72	neutral	0.79	neutral	-1.87	neutral	-2.44	low_impact	1.71	0.71	neutral	0.63	neutral	4.21	23.90	deleterious	0.4	0.5	0.46	neutral	0.45	neutral	0.53	disease	0.52	disease	0	0.89	neutral	0.41	neutral	-2	neutral	0.70	deleterious	-1.7	low_impact	0.46	medium_impact	0.36	medium_impact	0.62	0.8	25.37	16.95	0.24	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14032	14032	A	C	MI.22857	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1696	566	I	L	Att/Ctt	-4.42	0	0	benign	0.3	neutral	0.7	neutral	1.05	neutral	0.26	neutral	-0.24	neutral_impact	0.02	0.79	neutral	0.97	neutral	1.62	13.96	neutral	0.45	0.55	0.37	neutral	0.09	neutral	0.19	neutral	0.27	neutral	5	0.23	neutral	0.7	deleterious	-6	neutral	0.64	deleterious	-0.4	medium_impact	0.44	medium_impact	-1.18	low_impact	0.74	0.85	25.37	16.95	0.44	N	0.61	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14033	14033	T	G	MI.22858	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1697	566	I	S	aTt/aGt	-0.06	0	0	possibly_damaging	0.66	neutral	0.44	neutral	0.76	neutral	-2.46	deleterious	-3.38	medium_impact	2.2	0.77	neutral	0.57	neutral	4.44	24.20	deleterious	0.28	0.45	0.49	neutral	0.56	disease	0.66	disease	0.72	disease	4	0.66	neutral	0.39	neutral	0	NA	0.76	deleterious	-1.02	low_impact	0.18	medium_impact	0.81	medium_impact	0.60	0.8	25.37	16.95	0.27	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14033	14033	T	A	MI.22859	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1697	566	I	N	aTt/aAt	-0.06	0	0	probably_damaging	0.91	neutral	0.33	neutral	0.72	deleterious	-3.95	deleterious	-4.35	medium_impact	2.75	0.74	neutral	0.43	neutral	4.81	24.80	deleterious	0.3	0.45	0.76	disease	0.61	disease	0.65	disease	0.73	disease	5	0.92	neutral	0.21	neutral	1	deleterious	0.80	deleterious	-1.7	low_impact	0.06	medium_impact	1.31	medium_impact	0.56	0.8	25.37	16.95	0.29	N	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6096	6096	A	C	MI.2286	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	193	65	M	L	Ata/Cta	-4.5	0	0	probably_damaging	0.91	deleterious	0	neutral	2.58	neutral	-1.1	neutral	-1.92	high_impact	4.62	0.58	damaging	0.1	damaging	3.16	22.60	deleterious	0.31	0.55	0.71	disease	0.82	disease	0.7	disease	0.73	disease	5	1	deleterious	0.05	neutral	6	deleterious	0.76	deleterious	-1.7	low_impact	-1.48	low_impact	3.17	high_impact	0.37	0.9	3.12	7.58	0.45	N	0.61	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14033	14033	T	C	MI.22860	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1697	566	I	T	aTt/aCt	-0.06	0	0	benign	0.09	neutral	0.43	neutral	0.79	neutral	-1.8	neutral	-2.19	neutral_impact	0.7	0.86	neutral	0.99	neutral	1.90	15.58	deleterious	0.45	0.55	0.39	neutral	0.26	neutral	0.36	neutral	0.44	neutral	1	0.51	neutral	0.67	deleterious	-6	neutral	0.70	deleterious	0.21	medium_impact	0.17	medium_impact	-0.56	medium_impact	0.63	0.8	25.37	16.95	0.38	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	COSM488754	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14034	14034	T	G	MI.22861	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1698	566	I	M	atT/atG	1.54	0	0	probably_damaging	0.95	neutral	0.25	neutral	0.79	neutral	-1.8	neutral	-1.07	low_impact	1.43	0.83	neutral	0.95	neutral	2.40	18.83	deleterious	0.51	0.6	0.58	disease	0.21	neutral	0.28	neutral	0.46	neutral	1	0.96	neutral	0.15	neutral	-2	neutral	0.70	deleterious	-1.96	low_impact	-0.03	medium_impact	0.1	medium_impact	0.75	0.85	25.37	16.95	0.44	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14034	14034	T	A	MI.22862	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1698	566	I	M	atT/atA	1.54	0	0	probably_damaging	0.95	neutral	0.25	neutral	0.79	neutral	-1.8	neutral	-1.07	low_impact	1.43	0.83	neutral	0.95	neutral	2.65	20.50	deleterious	0.51	0.6	0.58	disease	0.21	neutral	0.28	neutral	0.46	neutral	1	0.96	neutral	0.15	neutral	-2	neutral	0.70	deleterious	-1.96	low_impact	-0.03	medium_impact	0.1	medium_impact	0.75	0.85	25.37	16.95	0.44	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14035	14035	T	G	MI.22863	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1699	567	S	A	Tca/Gca	-6.25	0	0	benign	0.01	neutral	0.59	neutral	1.11	neutral	0.96	neutral	-0.46	neutral_impact	-0.42	0.82	neutral	0.99	neutral	1.57	13.67	neutral	0.46	0.55	0.45	neutral	0.06	neutral	0.19	neutral	0.24	neutral	5	0.39	neutral	0.79	deleterious	-6	neutral	0.68	deleterious	1.15	medium_impact	0.32	medium_impact	-1.59	low_impact	0.52	0.8	15.09	12.11	0.43	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14035	14035	T	C	MI.22864	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1699	567	S	P	Tca/Cca	-6.25	0	0	possibly_damaging	0.8	neutral	0.21	neutral	0.9	neutral	-2.62	deleterious	-3.19	low_impact	1.67	0.66	neutral	0.62	neutral	4.12	23.80	deleterious	0.22	0.45	0.73	disease	0.75	disease	0.61	disease	0.7	disease	4	0.88	neutral	0.21	neutral	-3	neutral	0.83	deleterious	-1.32	low_impact	-0.09	medium_impact	0.32	medium_impact	0.44	0.8	15.09	12.11	0.28	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14035	14035	T	A	MI.22865	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1699	567	S	T	Tca/Aca	-6.25	0	0	benign	0.04	neutral	0.44	neutral	0.96	neutral	-0.59	neutral	-1.46	neutral_impact	-0.11	0.89	neutral	0.98	neutral	2.24	17.80	deleterious	0.4	0.5	0.49	neutral	0.15	neutral	0.21	neutral	0.27	neutral	5	0.52	neutral	0.7	deleterious	-6	neutral	0.68	deleterious	0.57	medium_impact	0.18	medium_impact	-1.3	low_impact	0.63	0.8	15.09	12.11	0.37	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14036	14036	C	T	MI.22866	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1700	567	S	L	tCa/tTa	-2.35	0	0	benign	0.24	neutral	0.81	neutral	0.98	neutral	-0.2	deleterious	-3.59	low_impact	1.67	0.78	neutral	0.61	neutral	4.73	24.60	deleterious	0.37	0.5	0.57	disease	0.53	disease	0.45	neutral	0.5	neutral	0	0.14	neutral	0.79	deleterious	-6	neutral	0.74	deleterious	-0.27	medium_impact	0.58	medium_impact	0.32	medium_impact	0.77	0.85	15.09	12.11	0.2	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14036	14036	C	G	MI.22867	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1700	567	S	W	tCa/tGa	-2.35	0	0	probably_damaging	0.95	neutral	0.21	neutral	0.9	neutral	-2.83	deleterious	-4.85	medium_impact	2.48	0.77	neutral	0.42	neutral	4.48	24.20	deleterious	0.18	0.45	0.73	disease	0.73	disease	0.64	disease	0.73	disease	5	0.97	neutral	0.13	neutral	1	deleterious	0.80	deleterious	-1.96	low_impact	-0.09	medium_impact	1.06	medium_impact	0.50	0.8	15.09	12.11	0.27	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14038	14038	C	A	MI.22868	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1702	568	Q	K	Cag/Aag	-6.02	0	0	possibly_damaging	0.44	neutral	0.3	neutral	1.11	neutral	1.21	neutral	-0.67	neutral_impact	0.26	0.82	neutral	0.88	neutral	0.49	7.35	deleterious	0.55	0.6	0.35	neutral	0.16	neutral	0.46	neutral	0.29	neutral	4	0.66	neutral	0.43	neutral	-3	neutral	0.44	deleterious	-0.65	medium_impact	0.03	medium_impact	-0.97	medium_impact	0.66	0.8	31.67	22.55	0.37	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14038	14038	C	G	MI.22869	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1702	568	Q	E	Cag/Gag	-6.02	0	0	benign	0.36	neutral	0.27	neutral	1.06	neutral	0.71	neutral	-0.54	low_impact	0.92	0.85	neutral	0.64	neutral	-0.51	0.21	neutral	0.51	0.6	0.43	neutral	0.21	neutral	0.41	neutral	0.39	neutral	2	0.68	neutral	0.46	neutral	-6	neutral	0.37	neutral	-0.51	medium_impact	-0.01	medium_impact	-0.36	medium_impact	0.57	0.8	31.67	22.55	0.37	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6096	6096	A	T	MI.2287	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	193	65	M	L	Ata/Tta	-4.5	0	0	probably_damaging	0.91	deleterious	0	neutral	2.58	neutral	-1.1	neutral	-1.92	high_impact	4.62	0.58	damaging	0.1	damaging	3.25	22.80	deleterious	0.31	0.55	0.71	disease	0.82	disease	0.7	disease	0.73	disease	5	1	deleterious	0.05	neutral	6	deleterious	0.76	deleterious	-1.7	low_impact	-1.48	low_impact	3.17	high_impact	0.37	0.9	3.12	7.58	0.45	N	0.61	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14039	14039	A	C	MI.22870	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1703	568	Q	P	cAg/cCg	-6.71	0	0	possibly_damaging	0.86	neutral	0.23	neutral	0.94	neutral	-1.54	neutral	-1.86	low_impact	1.54	0.75	neutral	0.63	neutral	1.74	14.66	neutral	0.17	0.45	0.63	disease	0.53	disease	0.6	disease	0.72	disease	4	0.91	neutral	0.19	neutral	-3	neutral	0.72	deleterious	-1.5	low_impact	-0.06	medium_impact	0.2	medium_impact	0.56	0.8	31.67	22.55	0.33	N	0.81	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14039	14039	A	G	MI.22871	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1703	568	Q	R	cAg/cGg	-6.71	0	0	possibly_damaging	0.48	neutral	0.35	neutral	0.99	neutral	-0.19	neutral	-0.79	low_impact	1.34	0.82	neutral	0.63	neutral	-0.09	1.78	neutral	0.56	0.6	0.47	neutral	0.21	neutral	0.46	neutral	0.37	neutral	3	0.62	neutral	0.44	neutral	-3	neutral	0.44	deleterious	-0.71	medium_impact	0.08	medium_impact	0.02	medium_impact	0.46	0.8	31.67	22.55	0.38	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14039	14039	A	T	MI.22872	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1703	568	Q	L	cAg/cTg	-6.71	0	0	possibly_damaging	0.48	neutral	0.84	neutral	0.97	neutral	-0.49	neutral	-1.65	neutral_impact	0.74	0.82	neutral	0.98	neutral	-0.13	1.54	neutral	0.45	0.55	0.27	neutral	0.16	neutral	0.24	neutral	0.25	neutral	5	0.38	neutral	0.68	deleterious	-3	neutral	0.50	deleterious	-0.71	medium_impact	0.63	medium_impact	-0.53	medium_impact	0.31	0.8	31.67	22.55	0.31	N	0.24	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14040	14040	G	T	MI.22873	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1704	568	Q	H	caG/caT	-2.81	0	0.02	benign	0.03	neutral	0.55	neutral	0.95	neutral	-1.25	neutral	-0.18	neutral_impact	0.65	0.87	neutral	0.98	neutral	-0.24	0.89	neutral	0.62	0.65	0.58	disease	0.11	neutral	0.26	neutral	0.32	neutral	4	0.42	neutral	0.76	deleterious	-6	neutral	0.15	neutral	0.69	medium_impact	0.28	medium_impact	-0.61	medium_impact	0.69	0.85	31.67	22.55	0.39	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14040	14040	G	C	MI.22874	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1704	568	Q	H	caG/caC	-2.81	0	0.02	benign	0.03	neutral	0.55	neutral	0.95	neutral	-1.25	neutral	-0.18	neutral_impact	0.65	0.87	neutral	0.98	neutral	-0.34	0.53	neutral	0.62	0.65	0.58	disease	0.11	neutral	0.26	neutral	0.32	neutral	4	0.42	neutral	0.76	deleterious	-6	neutral	0.15	neutral	0.69	medium_impact	0.28	medium_impact	-0.61	medium_impact	0.69	0.85	31.67	22.55	0.39	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14041	14041	C	G	MI.22875	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1705	569	H	D	Cac/Gac	-11.29	0	0	benign	0.2	neutral	0.42	neutral	0.99	neutral	-0.32	neutral	-0.69	low_impact	1.04	0.8	neutral	0.53	neutral	2.24	17.76	deleterious	0.29	0.45	0.51	disease	0.24	neutral	0.69	disease	0.48	neutral	0	0.49	neutral	0.61	deleterious	-6	neutral	0.54	deleterious	-0.17	medium_impact	0.16	medium_impact	-0.25	medium_impact	0.59	0.8	27.2	16.62	0.3	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14041	14041	C	T	MI.22876	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1705	569	H	Y	Cac/Tac	-11.29	0	0	benign	0.01	neutral	1	neutral	1.02	neutral	0.66	neutral	0.92	neutral_impact	0.69	0.87	neutral	0.87	neutral	-0.84	0.04	neutral	0.68	0.7	0.66	disease	0.16	neutral	0.54	disease	0.35	neutral	3	0.01	neutral	1	deleterious	-6	neutral	0.16	neutral	1.15	medium_impact	1.89	high_impact	-0.57	medium_impact	0.39	0.8	27.2	16.62	0.3	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14041	14041	C	A	MI.22877	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1705	569	H	N	Cac/Aac	-11.29	0	0	benign	0.15	neutral	0.48	neutral	1.05	neutral	1.45	neutral	0.09	neutral_impact	0.06	0.8	neutral	0.9	neutral	2.18	17.40	deleterious	0.66	0.7	0.56	disease	0.09	neutral	0.37	neutral	0.29	neutral	4	0.43	neutral	0.67	deleterious	-6	neutral	0.50	deleterious	-0.03	medium_impact	0.21	medium_impact	-1.15	low_impact	0.61	0.8	27.2	16.62	0.4	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14042	14042	A	G	MI.22878	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1706	569	H	R	cAc/cGc	-5.33	0	0	benign	0.2	neutral	0.53	neutral	1.01	neutral	0.21	neutral	-0.03	neutral_impact	0.69	0.79	neutral	0.58	neutral	-0.02	2.40	deleterious	0.69	0.75	0.55	disease	0.16	neutral	0.6	disease	0.31	neutral	4	0.36	neutral	0.67	deleterious	-6	neutral	0.52	deleterious	-0.17	medium_impact	0.26	medium_impact	-0.57	medium_impact	0.41	0.8	27.2	16.62	0.28	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14042	14042	A	T	MI.22879	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1706	569	H	L	cAc/cTc	-5.33	0	0	benign	0.03	neutral	0.76	neutral	1.15	neutral	2.56	neutral	2.31	neutral_impact	-1.54	0.82	neutral	0.95	neutral	0.03	2.88	deleterious	0.36	0.5	0.38	neutral	0.11	neutral	0.45	neutral	0.3	neutral	4	0.18	neutral	0.87	deleterious	-6	neutral	0.35	neutral	0.69	medium_impact	0.51	medium_impact	-2.61	low_impact	0.29	0.8	27.2	16.62	0.28	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6097	6097	T	C	MI.2288	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	194	65	M	T	aTa/aCa	7.07	1	0	probably_damaging	0.99	deleterious	0	neutral	2.4	deleterious	-3.43	deleterious	-3.82	high_impact	4.83	0.62	neutral	0.11	damaging	2.88	21.70	deleterious	0.36	0.55	0.72	disease	0.87	disease	0.73	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.64	low_impact	-1.48	low_impact	3.36	high_impact	0.32	0.9	3.12	7.58	0.73	P	0.79	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14042	14042	A	C	MI.22880	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1706	569	H	P	cAc/cCc	-5.33	0	0	benign	0.36	neutral	0.31	neutral	0.99	neutral	-0.74	neutral	-0.58	low_impact	1.04	0.68	neutral	0.58	neutral	1.93	15.77	deleterious	0.25	0.45	0.6	disease	0.48	neutral	0.72	disease	0.63	disease	3	0.63	neutral	0.48	deleterious	-6	neutral	0.70	deleterious	-0.51	medium_impact	0.04	medium_impact	-0.25	medium_impact	0.36	0.8	27.2	16.62	0.34	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14043	14043	C	G	MI.22881	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1707	569	H	Q	caC/caG	-1.44	0	0	benign	0.36	neutral	0.5	neutral	1.03	neutral	0.99	neutral	0.24	neutral_impact	-0.7	0.81	neutral	0.87	neutral	1.86	15.32	deleterious	0.6	0.65	0.45	neutral	0.08	neutral	0.31	neutral	0.25	neutral	5	0.42	neutral	0.57	deleterious	-6	neutral	0.51	deleterious	-0.51	medium_impact	0.23	medium_impact	-1.84	low_impact	0.50	0.8	27.2	16.62	0.38	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14043	14043	C	A	MI.22882	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1707	569	H	Q	caC/caA	-1.44	0	0	benign	0.36	neutral	0.5	neutral	1.03	neutral	0.99	neutral	0.24	neutral_impact	-0.7	0.81	neutral	0.87	neutral	2.20	17.51	deleterious	0.6	0.65	0.45	neutral	0.08	neutral	0.31	neutral	0.25	neutral	5	0.42	neutral	0.57	deleterious	-6	neutral	0.51	deleterious	-0.51	medium_impact	0.23	medium_impact	-1.84	low_impact	0.50	0.8	27.2	16.62	0.37	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14044	14044	C	G	MI.22883	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1708	570	Q	E	Caa/Gaa	-8.54	0	0	possibly_damaging	0.45	neutral	0.28	neutral	0.87	neutral	-1.95	neutral	-1.71	medium_impact	2.96	0.78	neutral	0.43	neutral	3.16	22.60	deleterious	0.53	0.6	0.37	neutral	0.46	neutral	0.47	neutral	0.5	neutral	0	0.68	neutral	0.42	neutral	0	NA	0.72	deleterious	-0.66	medium_impact	0.01	medium_impact	1.5	medium_impact	0.59	0.8	15.42	14.21	0.37	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14044	14044	C	A	MI.22884	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1708	570	Q	K	Caa/Aaa	-8.54	0	0	possibly_damaging	0.45	neutral	0.32	neutral	0.88	neutral	-1.85	neutral	-2.3	medium_impact	2.96	0.76	neutral	0.55	neutral	4.13	23.80	deleterious	0.48	0.55	0.35	neutral	0.43	neutral	0.33	neutral	0.46	neutral	1	0.64	neutral	0.44	neutral	0	NA	0.72	deleterious	-0.66	medium_impact	0.05	medium_impact	1.5	medium_impact	0.46	0.8	15.42	14.21	0.43	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14045	14045	A	T	MI.22885	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1709	570	Q	L	cAa/cTa	0.63	0	0	possibly_damaging	0.72	neutral	0.71	neutral	1.06	neutral	0.45	deleterious	-4.72	low_impact	1.61	0.78	neutral	0.68	neutral	3.95	23.60	deleterious	0.34	0.5	0.43	neutral	0.44	neutral	0.22	neutral	0.48	neutral	0	0.67	neutral	0.5	deleterious	-3	neutral	0.72	deleterious	-1.14	low_impact	0.45	medium_impact	0.27	medium_impact	0.27	0.8	15.42	14.21	0.26	N	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14045	14045	A	G	MI.22886	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1709	570	Q	R	cAa/cGa	0.63	0	0	possibly_damaging	0.66	neutral	0.35	neutral	0.86	neutral	-2.28	neutral	-2.28	medium_impact	2.96	0.75	neutral	0.52	neutral	3.62	23.20	deleterious	0.59	0.65	0.43	neutral	0.46	neutral	0.38	neutral	0.49	neutral	0	0.71	neutral	0.35	neutral	0	NA	0.73	deleterious	-1.02	low_impact	0.08	medium_impact	1.5	medium_impact	0.49	0.8	15.42	14.21	0.46	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14045	14045	A	C	MI.22887	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1709	570	Q	P	cAa/cCa	0.63	0	0	possibly_damaging	0.9	neutral	0.25	neutral	0.84	deleterious	-3.25	deleterious	-3.96	medium_impact	2.96	0.74	neutral	0.3	neutral	3.46	23.00	deleterious	0.18	0.45	0.62	disease	0.72	disease	0.64	disease	0.72	disease	4	0.93	neutral	0.18	neutral	0	NA	0.82	deleterious	-1.65	low_impact	-0.03	medium_impact	1.5	medium_impact	0.52	0.8	15.42	14.21	0.3	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14046	14046	A	T	MI.22888	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1710	570	Q	H	caA/caT	0.86	0	0	benign	0.02	neutral	0.54	neutral	0.87	neutral	-2.05	neutral	-1.5	neutral_impact	0.57	0.86	neutral	0.96	neutral	2.41	18.90	deleterious	0.56	0.6	0.64	disease	0.35	neutral	0.32	neutral	0.62	disease	2	0.43	neutral	0.76	deleterious	-6	neutral	0.76	deleterious	0.86	medium_impact	0.27	medium_impact	-0.68	medium_impact	0.58	0.8	15.42	14.21	0.31	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14046	14046	A	C	MI.22889	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1710	570	Q	H	caA/caC	0.86	0	0	benign	0.02	neutral	0.54	neutral	0.87	neutral	-2.05	neutral	-1.5	neutral_impact	0.57	0.86	neutral	0.96	neutral	2.24	17.79	deleterious	0.56	0.6	0.64	disease	0.35	neutral	0.32	neutral	0.62	disease	2	0.43	neutral	0.76	deleterious	-6	neutral	0.76	deleterious	0.86	medium_impact	0.27	medium_impact	-0.68	medium_impact	0.58	0.8	15.42	14.21	0.31	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6097	6097	T	A	MI.2289	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	194	65	M	K	aTa/aAa	7.07	1	0	probably_damaging	0.98	deleterious	0	neutral	2.37	deleterious	-4.69	deleterious	-3.83	high_impact	5.17	0.54	damaging	0.07	damaging	3.93	23.50	deleterious	0.15	0.55	0.32	neutral	0.93	disease	0.78	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.35	low_impact	-1.48	low_impact	3.68	high_impact	0.33	0.9	3.12	7.58	0.66	P	0.93	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14047	14047	A	C	MI.22890	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1711	571	I	L	Atc/Ctc	-1.21	0	0	benign	0.08	neutral	0.76	neutral	1.09	neutral	0.9	neutral	0.35	neutral_impact	0.18	0.79	neutral	0.98	neutral	-0.80	0.04	neutral	0.56	0.6	0.25	neutral	0.06	neutral	0.19	neutral	0.26	neutral	5	0.14	neutral	0.84	deleterious	-6	neutral	0.19	neutral	0.26	medium_impact	0.51	medium_impact	-1.04	low_impact	0.39	0.8	30.18	19.78	0.43	N	0.27	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14047	14047	A	G	MI.22891	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1711	571	I	V	Atc/Gtc	-1.21	0	0	benign	0.01	neutral	0.51	neutral	1.04	neutral	0.4	neutral	-0.15	low_impact	1.75	0.85	neutral	0.94	neutral	-0.49	0.23	neutral	0.6	0.65	0.38	neutral	0.08	neutral	0.35	neutral	0.31	neutral	4	0.48	neutral	0.75	deleterious	-6	neutral	0.11	neutral	1.15	medium_impact	0.24	medium_impact	0.4	medium_impact	0.36	0.8	30.18	19.78	0.42	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14047	14047	A	T	MI.22892	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1711	571	I	F	Atc/Ttc	-1.21	0	0	possibly_damaging	0.47	neutral	0.73	neutral	0.93	neutral	-1.53	neutral	-1.28	low_impact	1.4	0.78	neutral	0.6	neutral	2.14	17.12	deleterious	0.6	0.65	0.41	neutral	0.33	neutral	0.5	neutral	0.48	neutral	0	0.36	neutral	0.63	deleterious	-3	neutral	0.57	deleterious	-0.7	medium_impact	0.47	medium_impact	0.08	medium_impact	0.35	0.8	30.18	19.78	0.23	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14048	14048	T	C	MI.22893	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1712	571	I	T	aTc/aCc	-7.4	0	0	benign	0.01	neutral	0.43	neutral	1.01	neutral	0.17	neutral	-1.27	neutral_impact	-0.84	0.88	neutral	0.98	neutral	-0.45	0.29	neutral	0.54	0.6	0.31	neutral	0.14	neutral	0.23	neutral	0.3	neutral	4	0.56	neutral	0.71	deleterious	-6	neutral	0.12	neutral	1.15	medium_impact	0.17	medium_impact	-1.97	low_impact	0.24	0.8	30.18	19.78	0.4	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14048	14048	T	A	MI.22894	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1712	571	I	N	aTc/aAc	-7.4	0	0	possibly_damaging	0.47	neutral	0.3	neutral	0.92	neutral	-1.95	neutral	-2.42	neutral_impact	0.2	0.82	neutral	0.68	neutral	3.23	22.80	deleterious	0.41	0.5	0.67	disease	0.4	neutral	0.26	neutral	0.62	disease	2	0.67	neutral	0.42	neutral	-3	neutral	0.60	deleterious	-0.7	medium_impact	0.03	medium_impact	-1.02	low_impact	0.43	0.8	30.18	19.78	0.31	N	0.46	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14048	14048	T	G	MI.22895	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1712	571	I	S	aTc/aGc	-7.4	0	0	benign	0.03	neutral	0.44	neutral	1.03	neutral	0.34	neutral	-1.58	neutral_impact	-0.04	0.87	neutral	0.87	neutral	1.09	11.18	neutral	0.46	0.55	0.53	disease	0.38	neutral	0.25	neutral	0.41	neutral	2	0.53	neutral	0.71	deleterious	-6	neutral	0.43	deleterious	0.69	medium_impact	0.18	medium_impact	-1.24	low_impact	0.38	0.8	30.18	19.78	0.31	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14049	14049	C	G	MI.22896	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1713	571	I	M	atC/atG	-2.81	0	0	benign	0.08	neutral	0.27	neutral	1.05	neutral	0.58	neutral	0.71	neutral_impact	0.16	0.82	neutral	0.99	neutral	1.04	10.90	neutral	0.69	0.75	0.26	neutral	0.09	neutral	0.18	neutral	0.3	neutral	4	0.7	neutral	0.6	deleterious	-6	neutral	0.54	deleterious	0.26	medium_impact	-0.01	medium_impact	-1.06	low_impact	0.50	0.8	30.18	19.78	0.54	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14049	14049	C	A	MI.22897	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1713	571	I	M	atC/atA	-2.81	0	0	benign	0.08	neutral	0.27	neutral	1.05	neutral	0.58	neutral	0.71	neutral_impact	0.16	0.82	neutral	0.99	neutral	1.44	13.02	neutral	0.69	0.75	0.26	neutral	0.09	neutral	0.18	neutral	0.3	neutral	4	0.7	neutral	0.6	deleterious	-6	neutral	0.54	deleterious	0.26	medium_impact	-0.01	medium_impact	-1.06	low_impact	0.50	0.8	30.18	19.78	0.54	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14050	14050	T	A	MI.22898	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1714	572	S	T	Tcc/Acc	-5.79	0	0	benign	0.04	neutral	0.48	neutral	1.02	neutral	0.19	neutral	0.15	neutral_impact	-0.26	0.91	neutral	0.98	neutral	1.78	14.87	neutral	0.44	0.55	0.37	neutral	0.05	neutral	0.37	neutral	0.25	neutral	5	0.48	neutral	0.72	deleterious	-6	neutral	0.63	deleterious	0.57	medium_impact	0.21	medium_impact	-1.44	low_impact	0.58	0.8	29.52	23.23	0.44	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14050	14050	T	G	MI.22899	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1714	572	S	A	Tcc/Gcc	-5.79	0	0	possibly_damaging	0.45	neutral	0.59	neutral	0.97	neutral	-0.36	neutral	-0.55	neutral_impact	0.26	0.84	neutral	0.92	neutral	1.55	13.60	neutral	0.52	0.6	0.38	neutral	0.03	neutral	0.23	neutral	0.22	neutral	6	0.41	neutral	0.57	deleterious	-3	neutral	0.63	deleterious	-0.66	medium_impact	0.32	medium_impact	-0.97	medium_impact	0.52	0.8	29.52	23.23	0.37	N	0.21	polymorphism	1	0.01	rs879112261	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8633	8633	A	T	MI.229	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	107	36	Y	F	tAt/tTt	2.9	0.2	0	benign	0.14	neutral	0.71	neutral	4.39	neutral	-0.32	neutral	-1.44	neutral_impact	0.02	0.87	neutral	0.54	neutral	1.28	12.15	neutral	0.55	0.65	0.8	disease	0.39	neutral	0.35	neutral	0.66	disease	3	0.17	neutral	0.79	deleterious	-6	neutral	0.29	neutral	-0.01	medium_impact	0.51	medium_impact	-1.08	low_impact	0.39	0.9	29.2	23.72	0.26	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6098	6098	A	C	MI.2290	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	195	65	M	I	atA/atC	7.53	1	0	probably_damaging	0.96	deleterious	0	neutral	2.51	neutral	-1.69	deleterious	-2.55	high_impact	4.08	0.52	damaging	0.11	damaging	3.24	22.80	deleterious	0.35	0.55	0.78	disease	0.91	disease	0.7	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-2.06	low_impact	-1.48	low_impact	2.67	high_impact	0.52	0.9	3.12	7.58	0.56	P	0.87	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14050	14050	T	C	MI.22900	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1714	572	S	P	Tcc/Ccc	-5.79	0	0	possibly_damaging	0.86	neutral	0.22	neutral	0.93	neutral	-1.09	neutral	-1.7	neutral_impact	0.04	0.75	neutral	0.84	neutral	2.33	18.39	deleterious	0.4	0.5	0.52	disease	0.15	neutral	0.38	neutral	0.25	neutral	5	0.91	neutral	0.18	neutral	-3	neutral	0.70	deleterious	-1.5	low_impact	-0.07	medium_impact	-1.17	low_impact	0.55	0.8	29.52	23.23	0.4	N	0.63	polymorphism	1	0.03	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14051	14051	C	T	MI.22901	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1715	572	S	F	tCc/tTc	-0.52	0	0	possibly_damaging	0.84	neutral	0.77	neutral	0.89	neutral	-2.11	neutral	-1.37	low_impact	0.92	0.8	neutral	0.75	neutral	2.19	17.42	deleterious	0.32	0.5	0.6	disease	0.24	neutral	0.33	neutral	0.53	disease	1	0.81	neutral	0.47	neutral	-3	neutral	0.70	deleterious	-1.43	low_impact	0.52	medium_impact	-0.36	medium_impact	0.32	0.8	29.52	23.23	0.23	N	0.81	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14051	14051	C	G	MI.22902	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1715	572	S	C	tCc/tGc	-0.52	0	0	probably_damaging	0.97	neutral	0.18	neutral	0.87	deleterious	-4.23	neutral	-1.59	low_impact	1.9	0.73	neutral	0.42	neutral	2.42	18.98	deleterious	0.37	0.5	0.83	disease	0.22	neutral	0.31	neutral	0.51	disease	0	0.98	neutral	0.11	neutral	-2	neutral	0.71	deleterious	-2.18	low_impact	-0.13	medium_impact	0.53	medium_impact	0.56	0.8	29.52	23.23	0.37	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14051	14051	C	A	MI.22903	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1715	572	S	Y	tCc/tAc	-0.52	0	0	probably_damaging	0.95	neutral	1	neutral	0.88	neutral	-2.53	neutral	-1.36	low_impact	1.54	0.82	neutral	0.78	neutral	1.52	13.42	neutral	0.32	0.5	0.44	neutral	0.23	neutral	0.44	neutral	0.42	neutral	2	0.95	neutral	0.53	deleterious	-2	neutral	0.67	deleterious	-1.96	low_impact	1.89	high_impact	0.2	medium_impact	0.56	0.8	29.52	23.23	0.23	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14053	14053	A	T	MI.22904	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1717	573	T	S	Acc/Tcc	-5.33	0	0.02	benign	0.02	neutral	0.43	neutral	1	neutral	0.05	neutral	0.41	neutral_impact	-0.38	0.84	neutral	1	neutral	-0.18	1.23	neutral	0.43	0.55	0.29	neutral	0.09	neutral	0.24	neutral	0.28	neutral	4	0.55	neutral	0.71	deleterious	-6	neutral	0.12	neutral	0.86	medium_impact	0.17	medium_impact	-1.55	low_impact	0.38	0.8	23.71	13.29	0.46	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14053	14053	A	G	MI.22905	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1717	573	T	A	Acc/Gcc	-5.33	0	0.02	benign	0.01	neutral	0.53	neutral	1.1	neutral	1.16	neutral	1.83	neutral_impact	0.28	0.88	neutral	1	neutral	-0.55	0.17	neutral	0.57	0.65	0.28	neutral	0.05	neutral	0.23	neutral	0.23	neutral	5	0.46	neutral	0.76	deleterious	-6	neutral	0.09	neutral	1.15	medium_impact	0.26	medium_impact	-0.95	medium_impact	0.31	0.8	23.71	13.29	0.31	N	0.00	polymorphism	1	0.01	rs200134839	.	.	.	.	prostate tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14053	14053	A	C	MI.22906	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1717	573	T	P	Acc/Ccc	-5.33	0	0.02	benign	0.41	neutral	0.21	neutral	0.97	neutral	-0.74	neutral	-1.41	medium_impact	1.98	0.74	neutral	0.76	neutral	1.06	10.99	neutral	0.22	0.45	0.79	disease	0.44	neutral	0.71	disease	0.67	disease	3	0.76	neutral	0.4	neutral	-3	neutral	0.29	neutral	-0.6	medium_impact	-0.09	medium_impact	0.61	medium_impact	0.31	0.8	23.71	13.29	0.37	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14054	14054	C	T	MI.22907	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1718	573	T	I	aCc/aTc	-2.81	0	0	benign	0.01	neutral	0.41	neutral	1.01	neutral	0.11	neutral	-0.95	neutral_impact	-0.57	0.76	neutral	0.84	neutral	0.50	7.42	deleterious	0.31	0.45	0.51	disease	0.1	neutral	0.22	neutral	0.24	neutral	5	0.58	neutral	0.7	deleterious	-6	neutral	0.14	neutral	1.15	medium_impact	0.15	medium_impact	-1.72	low_impact	0.48	0.8	23.71	13.29	0.38	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14054	14054	C	G	MI.22908	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1718	573	T	S	aCc/aGc	-2.81	0	0	benign	0.02	neutral	0.43	neutral	1	neutral	0.05	neutral	0.41	neutral_impact	-0.38	0.84	neutral	1	neutral	-0.47	0.26	neutral	0.43	0.55	0.29	neutral	0.09	neutral	0.24	neutral	0.28	neutral	4	0.55	neutral	0.71	deleterious	-6	neutral	0.12	neutral	0.86	medium_impact	0.17	medium_impact	-1.55	low_impact	0.38	0.8	23.71	13.29	0.43	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14054	14054	C	A	MI.22909	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1718	573	T	N	aCc/aAc	-2.81	0	0	benign	0.26	neutral	0.32	neutral	0.99	neutral	-0.16	neutral	-1.65	medium_impact	1.98	0.79	neutral	0.68	neutral	0.75	9.14	deleterious	0.47	0.55	0.71	disease	0.25	neutral	0.48	neutral	0.57	disease	1	0.61	neutral	0.53	deleterious	-3	neutral	0.21	neutral	-0.32	medium_impact	0.05	medium_impact	0.61	medium_impact	0.43	0.8	23.71	13.29	0.34	N	0.17	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6098	6098	A	T	MI.2291	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	195	65	M	I	atA/atT	7.53	1	0	probably_damaging	0.96	deleterious	0	neutral	2.51	neutral	-1.69	deleterious	-2.55	high_impact	4.08	0.52	damaging	0.11	damaging	3.30	22.80	deleterious	0.35	0.55	0.78	disease	0.91	disease	0.7	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-2.06	low_impact	-1.48	low_impact	2.67	high_impact	0.52	0.9	3.12	7.58	0.56	P	0.87	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14056	14056	T	G	MI.22910	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1720	574	S	A	Tcc/Gcc	-9.46	0	0	benign	0.08	neutral	0.59	neutral	0.64	neutral	-2.13	neutral	-1.85	low_impact	1.57	0.88	neutral	0.96	neutral	0.50	7.46	deleterious	0.58	0.65	0.47	neutral	0.13	neutral	0.44	neutral	0.3	neutral	4	0.33	neutral	0.76	deleterious	-6	neutral	0.16	neutral	0.26	medium_impact	0.32	medium_impact	0.23	medium_impact	0.70	0.85	5.97	9.72	0.4	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14056	14056	T	C	MI.22911	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1720	574	S	P	Tcc/Ccc	-9.46	0	0	probably_damaging	0.94	neutral	0.21	neutral	0.53	deleterious	-4.83	deleterious	-3.99	medium_impact	2.47	0.73	neutral	0.6	neutral	2.90	21.80	deleterious	0.31	0.45	0.76	disease	0.55	disease	0.64	disease	0.55	disease	1	0.96	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-1.88	low_impact	-0.09	medium_impact	1.05	medium_impact	0.66	0.8	5.97	9.72	0.31	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14056	14056	T	A	MI.22912	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1720	574	S	T	Tcc/Acc	-9.46	0	0	possibly_damaging	0.74	neutral	0.49	neutral	0.62	neutral	-2.38	neutral	-2.28	neutral_impact	0.61	0.86	neutral	0.85	neutral	1.25	11.98	neutral	0.39	0.5	0.47	neutral	0.21	neutral	0.28	neutral	0.38	neutral	3	0.72	neutral	0.38	neutral	-3	neutral	0.49	deleterious	-1.18	low_impact	0.22	medium_impact	-0.65	medium_impact	0.65	0.8	5.97	9.72	0.32	N	0.28	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14057	14057	C	G	MI.22913	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1721	574	S	C	tCc/tGc	-0.52	0	0	probably_damaging	0.98	neutral	0.17	neutral	0.53	deleterious	-5.33	deleterious	-3.86	medium_impact	2.82	0.71	neutral	0.39	neutral	3.68	23.30	deleterious	0.33	0.5	0.91	disease	0.54	disease	0.58	disease	0.75	disease	5	0.99	deleterious	0.1	neutral	1	deleterious	0.75	deleterious	-2.35	low_impact	-0.15	medium_impact	1.37	medium_impact	0.55	0.8	5.97	9.72	0.32	N	0.51	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14057	14057	C	A	MI.22914	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1721	574	S	Y	tCc/tAc	-0.52	0	0	probably_damaging	0.98	neutral	1	neutral	0.55	deleterious	-3.81	deleterious	-4.81	medium_impact	2.01	0.82	neutral	0.38	neutral	4.19	23.80	deleterious	0.28	0.45	0.82	disease	0.57	disease	0.45	neutral	0.55	disease	1	0.98	deleterious	0.51	deleterious	1	deleterious	0.78	deleterious	-2.35	low_impact	1.89	high_impact	0.63	medium_impact	0.66	0.8	5.97	9.72	0.19	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14057	14057	C	T	MI.22915	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1721	574	S	F	tCc/tTc	-0.52	0	0	probably_damaging	0.97	neutral	0.74	neutral	0.56	deleterious	-3.7	deleterious	-4.78	medium_impact	2.82	0.75	neutral	0.43	neutral	4.36	24.10	deleterious	0.3	0.45	0.86	disease	0.59	disease	0.62	disease	0.72	disease	4	0.96	neutral	0.39	neutral	1	deleterious	0.77	deleterious	-2.18	low_impact	0.48	medium_impact	1.37	medium_impact	0.34	0.8	5.97	9.72	0.21	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14059	14059	A	C	MI.22916	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1723	575	I	L	Atc/Ctc	-6.25	0	0	benign	0.08	neutral	1	neutral	1	neutral	-0.08	neutral	-0.26	neutral_impact	-0.18	0.81	neutral	0.83	neutral	0.30	5.69	deleterious	0.59	0.65	0.44	neutral	0.12	neutral	0.21	neutral	0.33	neutral	3	0.08	neutral	0.96	deleterious	-6	neutral	0.27	neutral	0.26	medium_impact	1.89	high_impact	-1.37	low_impact	0.49	0.8	22.06	12.92	0.28	N	0.24	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14059	14059	A	G	MI.22917	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1723	575	I	V	Atc/Gtc	-6.25	0	0	benign	0.02	neutral	0.6	neutral	1.01	neutral	0.31	neutral	0.17	neutral_impact	0.74	0.92	neutral	0.94	neutral	-0.02	2.39	deleterious	0.63	0.7	0.33	neutral	0.12	neutral	0.42	neutral	0.33	neutral	3	0.37	neutral	0.79	deleterious	-6	neutral	0.11	neutral	0.86	medium_impact	0.33	medium_impact	-0.53	medium_impact	0.39	0.8	22.06	12.92	0.29	N	0.36	polymorphism	1	0.00	rs878865648	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14059	14059	A	T	MI.22918	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1723	575	I	F	Atc/Ttc	-6.25	0	0	possibly_damaging	0.59	neutral	0.71	neutral	0.97	neutral	-1.84	neutral	-1.43	neutral_impact	0.57	0.8	neutral	0.66	neutral	2.45	19.13	deleterious	0.54	0.6	0.43	neutral	0.37	neutral	0.41	neutral	0.46	neutral	1	0.51	neutral	0.56	deleterious	-3	neutral	0.61	deleterious	-0.9	medium_impact	0.45	medium_impact	-0.68	medium_impact	0.59	0.8	22.06	12.92	0.22	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14060	14060	T	C	MI.22919	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1724	575	I	T	aTc/aCc	1.08	0	0	benign	0.02	neutral	0.81	neutral	1.13	neutral	1.94	neutral	1.07	neutral_impact	-0.94	0.9	neutral	0.99	neutral	-1.07	0.01	neutral	0.44	0.55	0.28	neutral	0.07	neutral	0.19	neutral	0.28	neutral	4	0.15	neutral	0.9	deleterious	-6	neutral	0.12	neutral	0.86	medium_impact	0.58	medium_impact	-2.06	low_impact	0.37	0.8	22.06	12.92	0.39	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6099	6099	A	T	MI.2292	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	196	66	I	F	Atc/Ttc	2.21	1	0	possibly_damaging	0.57	deleterious	0	neutral	2.35	deleterious	-5.33	neutral	-2.47	high_impact	5.08	0.62	neutral	0.05	damaging	3.63	23.20	deleterious	0.26	0.55	0.73	disease	0.78	disease	0.62	disease	0.7	disease	4	1	deleterious	0.22	neutral	5	deleterious	0.68	deleterious	-0.87	medium_impact	-1.48	low_impact	3.59	high_impact	0.79	0.9	2.53	6.64	0.61	P	0.85	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14060	14060	T	G	MI.22920	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1724	575	I	S	aTc/aGc	1.08	0	0	benign	0.27	neutral	0.86	neutral	1.12	neutral	1.88	neutral	-0.18	neutral_impact	-0.36	0.83	neutral	0.98	neutral	1.03	10.83	neutral	0.43	0.55	0.36	neutral	0.35	neutral	0.28	neutral	0.46	neutral	1	0.15	neutral	0.8	deleterious	-6	neutral	0.46	deleterious	-0.34	medium_impact	0.67	medium_impact	-1.53	low_impact	0.49	0.8	22.06	12.92	0.32	N	0.39	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14060	14060	T	A	MI.22921	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1724	575	I	N	aTc/aAc	1.08	0	0	possibly_damaging	0.59	neutral	0.59	neutral	1.05	neutral	0.97	neutral	-0.99	neutral_impact	0.65	0.82	neutral	0.75	neutral	3.14	22.60	deleterious	0.4	0.5	0.5	disease	0.38	neutral	0.44	neutral	0.14	neutral	7	0.53	neutral	0.5	deleterious	-3	neutral	0.61	deleterious	-0.9	medium_impact	0.32	medium_impact	-0.61	medium_impact	0.61	0.8	22.06	12.92	0.26	N	0.46	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14061	14061	C	A	MI.22922	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1725	575	I	M	atC/atA	-3.04	0	0	benign	0.05	neutral	0.36	neutral	0.97	neutral	-1.44	neutral	-0.01	neutral_impact	0	0.86	neutral	0.99	neutral	2.38	18.69	deleterious	0.64	0.7	0.66	disease	0.13	neutral	0.22	neutral	0.42	neutral	2	0.61	neutral	0.66	deleterious	-6	neutral	0.63	deleterious	0.47	medium_impact	0.1	medium_impact	-1.2	low_impact	0.72	0.85	22.06	12.92	0.44	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14061	14061	C	G	MI.22923	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1725	575	I	M	atC/atG	-3.04	0	0	benign	0.05	neutral	0.36	neutral	0.97	neutral	-1.44	neutral	-0.01	neutral_impact	0	0.86	neutral	0.99	neutral	1.86	15.32	deleterious	0.64	0.7	0.66	disease	0.13	neutral	0.22	neutral	0.42	neutral	2	0.61	neutral	0.66	deleterious	-6	neutral	0.63	deleterious	0.47	medium_impact	0.1	medium_impact	-1.2	low_impact	0.72	0.85	22.06	12.92	0.44	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14062	14062	A	T	MI.22924	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1726	576	I	F	Atc/Ttc	-7.4	0	0	benign	0.41	neutral	0.71	neutral	0.92	neutral	-0.82	neutral	-0.6	medium_impact	2.4	0.81	neutral	0.78	neutral	0.97	10.52	neutral	0.55	0.6	0.49	neutral	0.38	neutral	0.5	neutral	0.42	neutral	2	0.31	neutral	0.65	deleterious	-3	neutral	0.47	deleterious	-0.6	medium_impact	0.45	medium_impact	0.99	medium_impact	0.56	0.8	23.05	14.51	0.26	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14062	14062	A	G	MI.22925	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1726	576	I	V	Atc/Gtc	-7.4	0	0	benign	0.01	neutral	0.52	neutral	0.93	neutral	-0.74	neutral	0.03	low_impact	1.6	0.87	neutral	0.97	neutral	-0.20	1.08	neutral	0.67	0.7	0.3	neutral	0.1	neutral	0.32	neutral	0.32	neutral	4	0.47	neutral	0.76	deleterious	-6	neutral	0.13	neutral	1.15	medium_impact	0.25	medium_impact	0.26	medium_impact	0.56	0.8	23.05	14.51	0.42	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14062	14062	A	C	MI.22926	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1726	576	I	L	Atc/Ctc	-7.4	0	0	benign	0.03	neutral	0.68	neutral	1.02	neutral	0.15	neutral	0.3	neutral_impact	0.74	0.8	neutral	0.97	neutral	0.02	2.80	deleterious	0.48	0.55	0.21	neutral	0.14	neutral	0.28	neutral	0.28	neutral	4	0.27	neutral	0.83	deleterious	-6	neutral	0.13	neutral	0.69	medium_impact	0.41	medium_impact	-0.53	medium_impact	0.54	0.8	23.05	14.51	0.37	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14063	14063	T	G	MI.22927	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1727	576	I	S	aTc/aGc	-4.42	0	0.01	benign	0.11	neutral	0.47	neutral	0.93	neutral	-0.73	neutral	0.06	low_impact	1.92	0.82	neutral	0.93	neutral	1.22	11.85	neutral	0.45	0.55	0.45	neutral	0.38	neutral	0.41	neutral	0.46	neutral	1	0.45	neutral	0.68	deleterious	-6	neutral	0.23	neutral	0.12	medium_impact	0.2	medium_impact	0.55	medium_impact	0.58	0.8	23.05	14.51	0.37	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14063	14063	T	A	MI.22928	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1727	576	I	N	aTc/aAc	-4.42	0	0.01	benign	0.01	neutral	0.34	neutral	0.85	neutral	-2.34	neutral	-0.52	medium_impact	2.4	0.83	neutral	0.72	neutral	1.53	13.47	neutral	0.39	0.5	0.77	disease	0.47	neutral	0.53	disease	0.65	disease	3	0.65	neutral	0.67	deleterious	-3	neutral	0.45	deleterious	1.15	medium_impact	0.07	medium_impact	0.99	medium_impact	0.68	0.85	23.05	14.51	0.35	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14063	14063	T	C	MI.22929	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1727	576	I	T	aTc/aCc	-4.42	0	0.01	benign	0	neutral	0.44	neutral	0.95	neutral	-0.51	neutral	0.77	neutral_impact	0.56	0.92	neutral	0.99	neutral	-1.01	0.02	neutral	0.5	0.6	0.4	neutral	0.12	neutral	0.28	neutral	0.28	neutral	5	0.56	neutral	0.72	deleterious	-6	neutral	0.13	neutral	2.1	high_impact	0.18	medium_impact	-0.69	medium_impact	0.51	0.8	23.05	14.51	0.42	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	T14063C	Potentially functional variant cosegregating with LHON3635A	+	-	Reported	1	.	P	P	neutral
chrM	6099	6099	A	G	MI.2293	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	196	66	I	V	Atc/Gtc	2.21	1	0	benign	0.03	deleterious	0	neutral	2.65	neutral	-1.25	neutral	-0.61	medium_impact	3.39	0.63	neutral	0.08	damaging	2.94	22.00	deleterious	0.42	0.55	0.22	neutral	0.43	neutral	0.39	neutral	0.39	neutral	2	1	deleterious	0.49	deleterious	1	deleterious	0.16	neutral	0.66	medium_impact	-1.48	low_impact	2.03	high_impact	0.64	0.9	2.53	6.64	0.53	P	0.23	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14064	14064	C	G	MI.22930	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1728	576	I	M	atC/atG	-2.58	0	0.01	possibly_damaging	0.61	neutral	0.24	neutral	0.9	neutral	-1.17	neutral	0.41	low_impact	1.68	0.83	neutral	0.98	neutral	1.46	13.12	neutral	0.67	0.7	0.43	neutral	0.15	neutral	0.31	neutral	0.32	neutral	4	0.77	neutral	0.32	neutral	-3	neutral	0.51	deleterious	-0.93	medium_impact	-0.04	medium_impact	0.33	medium_impact	0.74	0.85	23.05	14.51	0.46	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14064	14064	C	A	MI.22931	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1728	576	I	M	atC/atA	-2.58	0	0.01	possibly_damaging	0.61	neutral	0.24	neutral	0.9	neutral	-1.17	neutral	0.41	low_impact	1.68	0.83	neutral	0.98	neutral	1.91	15.64	deleterious	0.67	0.7	0.43	neutral	0.15	neutral	0.31	neutral	0.32	neutral	4	0.77	neutral	0.32	neutral	-3	neutral	0.51	deleterious	-0.93	medium_impact	-0.04	medium_impact	0.33	medium_impact	0.74	0.85	23.05	14.51	0.46	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14065	14065	A	G	MI.22932	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1729	577	T	A	Acc/Gcc	-8.31	0	0	benign	0.02	neutral	0.76	neutral	0.99	neutral	-0.17	neutral	-1.8	medium_impact	2.67	0.79	neutral	0.75	neutral	0.71	8.89	deleterious	0.76	0.8	0.35	neutral	0.35	neutral	0.46	neutral	0.47	neutral	1	0.2	neutral	0.87	deleterious	-3	neutral	0.22	neutral	0.86	medium_impact	0.51	medium_impact	1.24	medium_impact	0.50	0.8	14.76	11.3	0.27	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14065	14065	A	C	MI.22933	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1729	577	T	P	Acc/Ccc	-8.31	0	0	possibly_damaging	0.73	neutral	0.3	neutral	0.9	neutral	-2.84	deleterious	-3.18	medium_impact	2.47	0.61	neutral	0.37	neutral	3.36	22.90	deleterious	0.16	0.45	0.55	disease	0.8	disease	0.7	disease	0.74	disease	5	0.79	neutral	0.29	neutral	0	NA	0.70	deleterious	-1.16	low_impact	0.03	medium_impact	1.05	medium_impact	0.63	0.8	14.76	11.3	0.26	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14065	14065	A	T	MI.22934	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1729	577	T	S	Acc/Tcc	-8.31	0	0	benign	0.03	neutral	0.8	neutral	1.02	neutral	0.25	neutral	-1.59	neutral_impact	-0.1	0.85	neutral	0.92	neutral	0.13	3.89	deleterious	0.56	0.6	0.27	neutral	0.18	neutral	0.2	neutral	0.26	neutral	5	0.14	neutral	0.89	deleterious	-6	neutral	0.42	neutral	0.69	medium_impact	0.57	medium_impact	-1.29	low_impact	0.57	0.8	14.76	11.3	0.34	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14066	14066	C	G	MI.22935	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1730	577	T	S	aCc/aGc	-2.35	0	0	benign	0.03	neutral	0.8	neutral	1.02	neutral	0.25	neutral	-1.59	neutral_impact	-0.1	0.85	neutral	0.92	neutral	0.35	6.19	deleterious	0.56	0.6	0.27	neutral	0.18	neutral	0.2	neutral	0.26	neutral	5	0.14	neutral	0.89	deleterious	-6	neutral	0.42	neutral	0.69	medium_impact	0.57	medium_impact	-1.29	low_impact	0.57	0.8	14.76	11.3	0.31	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14066	14066	C	A	MI.22936	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1730	577	T	N	aCc/aAc	-2.35	0	0	possibly_damaging	0.51	neutral	0.63	neutral	0.97	neutral	-0.35	deleterious	-2.71	medium_impact	2.12	0.76	neutral	0.8	neutral	2.32	18.33	deleterious	0.57	0.65	0.42	neutral	0.54	disease	0.29	neutral	0.48	neutral	0	0.43	neutral	0.56	deleterious	0	NA	0.60	deleterious	-0.76	medium_impact	0.36	medium_impact	0.73	medium_impact	0.73	0.85	14.76	11.3	0.27	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14066	14066	C	T	MI.22937	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1730	577	T	I	aCc/aTc	-2.35	0	0	benign	0.02	neutral	0.32	neutral	1.13	neutral	1.12	neutral	-1.12	medium_impact	2.33	0.88	neutral	0.98	neutral	0.70	8.85	deleterious	0.5	0.6	0.53	disease	0.59	disease	0.35	neutral	0.49	neutral	0	0.67	neutral	0.65	deleterious	-3	neutral	0.18	neutral	0.86	medium_impact	0.05	medium_impact	0.93	medium_impact	0.52	0.8	14.76	11.3	0.33	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14068	14068	T	A	MI.22938	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1732	578	S	T	Tca/Aca	-13.81	0	0	benign	0.07	neutral	0.5	neutral	0.94	neutral	-0.54	neutral	-2.12	neutral_impact	0.66	0.93	neutral	0.99	neutral	2.56	19.88	deleterious	0.46	0.55	0.39	neutral	0.18	neutral	0.28	neutral	0.32	neutral	4	0.44	neutral	0.72	deleterious	-6	neutral	0.69	deleterious	0.32	medium_impact	0.23	medium_impact	-0.6	medium_impact	0.70	0.85	6.47	11	0.42	N	0.01	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14068	14068	T	G	MI.22939	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1732	578	S	A	Tca/Gca	-13.81	0	0	possibly_damaging	0.62	neutral	0.6	neutral	0.89	neutral	-1.29	neutral	-2.47	low_impact	1.64	0.87	neutral	0.88	neutral	3.84	23.40	deleterious	0.6	0.65	0.46	neutral	0.3	neutral	0.44	neutral	0.47	neutral	1	0.56	neutral	0.49	deleterious	-3	neutral	0.71	deleterious	-0.95	medium_impact	0.33	medium_impact	0.3	medium_impact	0.63	0.8	6.47	11	0.32	N	0.37	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6099	6099	A	C	MI.2294	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	196	66	I	L	Atc/Ctc	2.21	1	0	benign	0.07	deleterious	0	neutral	2.53	neutral	-1.98	neutral	-1.19	medium_impact	2.9	0.67	neutral	0.06	damaging	3.66	23.20	deleterious	0.26	0.55	0.28	neutral	0.55	disease	0.48	neutral	0.45	neutral	1	1	deleterious	0.47	neutral	1	deleterious	0.20	neutral	0.3	medium_impact	-1.48	low_impact	1.58	medium_impact	0.67	0.9	2.53	6.64	0.46	N	0.61	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14068	14068	T	C	MI.22940	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1732	578	S	P	Tca/Cca	-13.81	0	0	probably_damaging	0.92	neutral	0.23	neutral	0.84	neutral	-2.41	deleterious	-4.15	medium_impact	2.15	0.65	neutral	0.6	neutral	4.15	23.80	deleterious	0.33	0.5	0.74	disease	0.81	disease	0.7	disease	0.66	disease	3	0.95	neutral	0.16	neutral	1	deleterious	0.87	deleterious	-1.75	low_impact	-0.06	medium_impact	0.76	medium_impact	0.64	0.8	6.47	11	0.31	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	COSM6716776	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14069	14069	C	T	MI.22941	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1733	578	S	L	tCa/tTa	0.86	0	0	possibly_damaging	0.73	neutral	0.72	neutral	0.89	neutral	-1.32	deleterious	-4.88	low_impact	1.7	0.84	neutral	0.66	neutral	4.76	24.70	deleterious	0.51	0.6	0.43	neutral	0.69	disease	0.45	neutral	0.52	disease	0	0.67	neutral	0.5	deleterious	-3	neutral	0.74	deleterious	-1.16	low_impact	0.46	medium_impact	0.35	medium_impact	0.85	0.9	6.47	11	0.21	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14069	14069	C	G	MI.22942	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1733	578	S	W	tCa/tGa	0.86	0	0	probably_damaging	0.99	neutral	0.18	neutral	0.81	deleterious	-5.43	deleterious	-5.84	medium_impact	2.85	0.76	neutral	0.44	neutral	4.50	24.30	deleterious	0.24	0.45	0.7	disease	0.83	disease	0.57	disease	0.77	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-2.64	low_impact	-0.13	medium_impact	1.4	medium_impact	0.55	0.8	6.47	11	0.32	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14071	14071	A	T	MI.22943	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1735	579	T	S	Acc/Tcc	-7.17	0	0	benign	0.09	neutral	0.4	neutral	1.03	neutral	0.33	neutral	0.25	neutral_impact	0.52	0.88	neutral	0.99	neutral	0.09	3.51	deleterious	0.58	0.65	0.34	neutral	0.26	neutral	0.25	neutral	0.44	neutral	1	0.55	neutral	0.66	deleterious	-6	neutral	0.16	neutral	0.21	medium_impact	0.14	medium_impact	-0.73	medium_impact	0.49	0.8	19.57	14.79	0.43	N	0.33	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14071	14071	A	G	MI.22944	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1735	579	T	A	Acc/Gcc	-7.17	0	0	benign	0.05	neutral	0.51	neutral	1.03	neutral	0.36	neutral	-2.07	neutral_impact	0.36	0.77	neutral	0.89	neutral	0.42	6.82	deleterious	0.63	0.7	0.32	neutral	0.18	neutral	0.26	neutral	0.28	neutral	5	0.44	neutral	0.73	deleterious	-6	neutral	0.42	neutral	0.47	medium_impact	0.24	medium_impact	-0.87	medium_impact	0.42	0.8	19.57	14.79	0.35	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14071	14071	A	C	MI.22945	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1735	579	T	P	Acc/Ccc	-7.17	0	0	probably_damaging	0.91	neutral	0.22	neutral	0.92	neutral	-2.06	neutral	-2.34	low_impact	1.87	0.74	neutral	0.76	neutral	2.59	20.10	deleterious	0.25	0.45	0.59	disease	0.73	disease	0.44	neutral	0.58	disease	2	0.94	neutral	0.16	neutral	-2	neutral	0.74	deleterious	-1.7	low_impact	-0.07	medium_impact	0.51	medium_impact	0.48	0.8	19.57	14.79	0.3	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14072	14072	C	G	MI.22946	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1736	579	T	S	aCc/aGc	-0.06	0	0	benign	0.09	neutral	0.4	neutral	1.03	neutral	0.33	neutral	0.25	neutral_impact	0.52	0.88	neutral	0.99	neutral	-0.24	0.91	neutral	0.58	0.65	0.34	neutral	0.26	neutral	0.25	neutral	0.44	neutral	1	0.55	neutral	0.66	deleterious	-6	neutral	0.16	neutral	0.21	medium_impact	0.14	medium_impact	-0.73	medium_impact	0.49	0.8	19.57	14.79	0.41	N	0.33	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14072	14072	C	A	MI.22947	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1736	579	T	N	aCc/aAc	-0.06	0	0	possibly_damaging	0.76	neutral	0.32	neutral	1.06	neutral	0.65	neutral	3.34	low_impact	1.24	0.8	neutral	0.99	neutral	0.88	9.93	deleterious	0.57	0.65	0.33	neutral	0.3	neutral	0.25	neutral	0.45	neutral	1	0.8	neutral	0.28	neutral	-3	neutral	0.52	deleterious	-1.22	low_impact	0.05	medium_impact	-0.07	medium_impact	0.67	0.85	19.57	14.79	0.37	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14072	14072	C	T	MI.22948	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1736	579	T	I	aCc/aTc	-0.06	0	0	probably_damaging	0.91	neutral	0.4	neutral	0.98	neutral	-0.25	deleterious	-3.07	low_impact	1.09	0.79	neutral	0.83	neutral	2.39	18.76	deleterious	0.41	0.5	0.32	neutral	0.43	neutral	0.28	neutral	0.45	neutral	1	0.91	neutral	0.25	neutral	-2	neutral	0.62	deleterious	-1.7	low_impact	0.14	medium_impact	-0.21	medium_impact	0.40	0.8	19.57	14.79	0.3	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14074	14074	C	G	MI.22949	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1738	580	Q	E	Caa/Gaa	-9.69	0	0	probably_damaging	1	neutral	1	neutral	0.63	neutral	-2.32	deleterious	-2.59	high_impact	3.71	0.66	neutral	0.16	damaging	3.25	22.80	deleterious	0.58	0.65	0.44	neutral	0.82	disease	0.79	disease	0.76	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.81	deleterious	-3.6	low_impact	1.89	high_impact	2.19	high_impact	0.42	0.8	NA	NA	0.3	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6100	6100	T	G	MI.2295	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	197	66	I	S	aTc/aGc	8.69	1	0	benign	0.28	deleterious	0	neutral	2.35	deleterious	-5.39	deleterious	-3.72	high_impact	5.08	0.64	neutral	0.09	damaging	4.13	23.80	deleterious	0.2	0.55	0.84	disease	0.78	disease	0.59	disease	0.73	disease	5	1	deleterious	0.36	neutral	2	deleterious	0.56	deleterious	-0.37	medium_impact	-1.48	low_impact	3.59	high_impact	0.53	0.9	2.53	6.64	0.61	P	0.62	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14074	14074	C	A	MI.22950	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1738	580	Q	K	Caa/Aaa	-9.69	0	0	probably_damaging	1	neutral	0.94	neutral	0.62	neutral	-2.48	deleterious	-3.47	medium_impact	3.37	0.59	damaging	0.13	damaging	4.16	23.80	deleterious	0.42	0.55	0.53	disease	0.88	disease	0.8	disease	0.82	disease	6	1	deleterious	0.47	deleterious	1	deleterious	0.85	deleterious	-3.6	low_impact	0.89	medium_impact	1.88	medium_impact	0.38	0.8	NA	NA	0.3	N	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14075	14075	A	C	MI.22951	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1739	580	Q	P	cAa/cCa	4.98	1	0	probably_damaging	1	neutral	0.29	neutral	0.54	deleterious	-4.57	deleterious	-5.18	medium_impact	3.37	0.62	neutral	0.16	damaging	3.44	23.00	deleterious	0.21	0.45	0.81	disease	0.91	disease	0.82	disease	0.87	disease	7	1	deleterious	0.15	neutral	1	deleterious	0.90	deleterious	-3.6	low_impact	0.02	medium_impact	1.88	medium_impact	0.39	0.8	NA	NA	0.49	N	0.95	disease_causing	0.69	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14075	14075	A	G	MI.22952	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1739	580	Q	R	cAa/cGa	4.98	1	0	probably_damaging	1	neutral	0.54	neutral	0.59	neutral	-2.97	deleterious	-3.46	medium_impact	2.74	0.7	neutral	0.15	damaging	3.63	23.20	deleterious	0.6	0.65	0.6	disease	0.89	disease	0.79	disease	0.83	disease	7	1	deleterious	0.27	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.27	medium_impact	1.3	medium_impact	0.32	0.8	NA	NA	0.42	N	0.85	polymorphism	0.89	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14075	14075	A	T	MI.22953	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1739	580	Q	L	cAa/cTa	4.98	1	0	probably_damaging	1	neutral	0.42	neutral	0.58	deleterious	-3.16	deleterious	-6.1	medium_impact	2.91	0.68	neutral	0.21	damaging	4.00	23.60	deleterious	0.35	0.5	0.74	disease	0.9	disease	0.73	disease	0.79	disease	6	1	deleterious	0.21	neutral	1	deleterious	0.87	deleterious	-3.6	low_impact	0.16	medium_impact	1.46	medium_impact	0.17	0.8	NA	NA	0.42	N	0.96	disease_causing	0.64	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14076	14076	A	C	MI.22954	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1740	580	Q	H	caA/caC	3.38	1	0	probably_damaging	1	neutral	0.17	neutral	0.62	neutral	-2.54	deleterious	-4.17	medium_impact	1.97	0.79	neutral	0.48	neutral	3.45	23.00	deleterious	0.61	0.65	0.6	disease	0.58	disease	0.64	disease	0.49	neutral	0	1	deleterious	0.09	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	-0.15	medium_impact	0.6	medium_impact	0.50	0.8	NA	NA	0.38	N	0.94	polymorphism	0.76	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14076	14076	A	T	MI.22955	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1740	580	Q	H	caA/caT	3.38	1	0	probably_damaging	1	neutral	0.17	neutral	0.62	neutral	-2.54	deleterious	-4.17	medium_impact	1.97	0.79	neutral	0.48	neutral	3.65	23.20	deleterious	0.61	0.65	0.6	disease	0.58	disease	0.64	disease	0.49	neutral	0	1	deleterious	0.09	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	-0.15	medium_impact	0.6	medium_impact	0.50	0.8	NA	NA	0.39	N	0.94	polymorphism	0.76	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14077	14077	A	G	MI.22956	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1741	581	K	E	Aaa/Gaa	1.31	0.98	0	probably_damaging	1	neutral	1	neutral	0.9	neutral	-0.96	deleterious	-2.79	medium_impact	3.3	0.83	neutral	0.24	damaging	3.90	23.50	deleterious	0.52	0.6	0.42	neutral	0.79	disease	0.65	disease	0.76	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.77	deleterious	-3.6	low_impact	1.89	high_impact	1.81	medium_impact	0.78	0.85	NA	NA	0.31	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14077	14077	A	C	MI.22957	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1741	581	K	Q	Aaa/Caa	1.31	0.98	0	probably_damaging	1	neutral	0.62	neutral	0.92	neutral	-0.77	deleterious	-2.71	low_impact	1.62	0.82	neutral	0.79	neutral	1.57	13.70	neutral	0.6	0.65	0.45	neutral	0.28	neutral	0.27	neutral	0.46	neutral	1	1	deleterious	0.31	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.35	medium_impact	0.28	medium_impact	0.75	0.85	NA	NA	0.36	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14078	14078	A	C	MI.22958	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1742	581	K	T	aAa/aCa	2.23	0.96	0	probably_damaging	1	neutral	0.64	neutral	0.92	neutral	-0.69	deleterious	-3.33	low_impact	1.21	0.83	neutral	0.73	neutral	2.52	19.59	deleterious	0.42	0.5	0.29	neutral	0.34	neutral	0.37	neutral	0.44	neutral	1	1	deleterious	0.32	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.37	medium_impact	-0.1	medium_impact	0.60	0.8	NA	NA	0.32	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14078	14078	A	T	MI.22959	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1742	581	K	M	aAa/aTa	2.23	0.96	0	probably_damaging	1	neutral	0.13	neutral	0.84	neutral	-2.21	deleterious	-3.95	medium_impact	2.61	0.83	neutral	0.31	neutral	3.84	23.40	deleterious	0.33	0.5	0.7	disease	0.6	disease	0.54	disease	0.68	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.22	medium_impact	1.18	medium_impact	0.41	0.8	NA	NA	0.41	N	0.80	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6100	6100	T	C	MI.2296	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	197	66	I	T	aTc/aCc	8.69	1	0	benign	0.02	deleterious	0	neutral	2.4	deleterious	-3.62	deleterious	-3.11	high_impact	4.53	0.62	neutral	0.08	damaging	3.35	22.90	deleterious	0.36	0.55	0.74	disease	0.67	disease	0.59	disease	0.67	disease	3	1	deleterious	0.49	deleterious	2	deleterious	0.30	neutral	0.83	medium_impact	-1.48	low_impact	3.08	high_impact	0.73	0.9	2.53	6.64	0.52	P	0.76	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14079	14079	A	T	MI.22960	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1743	581	K	N	aaA/aaT	1.08	0.45	0	probably_damaging	1	neutral	0.53	neutral	0.92	neutral	-0.75	deleterious	-3.36	medium_impact	2.06	0.75	neutral	0.34	neutral	4.14	23.80	deleterious	0.66	0.7	0.35	neutral	0.61	disease	0.42	neutral	0.49	neutral	0	1	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.26	medium_impact	0.68	medium_impact	0.83	0.9	NA	NA	0.22	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14079	14079	A	C	MI.22961	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1743	581	K	N	aaA/aaC	1.08	0.45	0	probably_damaging	1	neutral	0.53	neutral	0.92	neutral	-0.75	deleterious	-3.36	medium_impact	2.06	0.75	neutral	0.34	neutral	3.96	23.60	deleterious	0.66	0.7	0.35	neutral	0.61	disease	0.42	neutral	0.49	neutral	0	1	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-3.6	low_impact	0.26	medium_impact	0.68	medium_impact	0.83	0.9	NA	NA	0.22	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14080	14080	G	T	MI.22962	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1744	582	G	C	Ggc/Tgc	-0.29	0.08	0	probably_damaging	1	neutral	0.18	neutral	0.65	deleterious	-5.75	deleterious	-7.9	high_impact	3.78	0.63	neutral	0.24	damaging	4.28	24.00	deleterious	0.29	0.45	0.95	disease	0.89	disease	0.74	disease	0.84	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.6	low_impact	-0.13	medium_impact	2.25	high_impact	0.35	0.8	20.07	7.26	0.38	N	0.97	disease_causing	0.91	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14080	14080	G	C	MI.22963	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1744	582	G	R	Ggc/Cgc	-0.29	0.08	0	probably_damaging	1	neutral	0.35	neutral	0.69	neutral	-2.93	deleterious	-7.02	medium_impact	3.43	0.62	neutral	0.23	damaging	4.11	23.70	deleterious	0.28	0.45	0.83	disease	0.9	disease	0.76	disease	0.84	disease	7	1	deleterious	0.18	neutral	1	deleterious	0.91	deleterious	-3.6	low_impact	0.08	medium_impact	1.93	medium_impact	0.68	0.85	20.07	7.26	0.38	N	1.00	disease_causing	0.83	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14080	14080	G	A	MI.22964	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1744	582	G	S	Ggc/Agc	-0.29	0.08	0	possibly_damaging	0.78	neutral	0.4	neutral	0.78	neutral	-1.42	deleterious	-5.23	medium_impact	2.58	0.7	neutral	0.42	neutral	4.41	24.10	deleterious	0.29	0.45	0.67	disease	0.79	disease	0.67	disease	0.56	disease	1	0.78	neutral	0.31	neutral	0	NA	0.85	deleterious	-1.27	low_impact	0.14	medium_impact	1.15	medium_impact	0.56	0.8	20.07	7.26	0.3	N	1.00	disease_causing	0.7	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14081	14081	G	A	MI.22965	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1745	582	G	D	gGc/gAc	2.92	1	0	probably_damaging	0.99	neutral	0.21	neutral	0.7	neutral	-2.81	deleterious	-6.14	high_impact	3.78	0.65	neutral	0.26	damaging	4.02	23.60	deleterious	0.23	0.45	0.79	disease	0.89	disease	0.78	disease	0.84	disease	7	0.99	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-2.64	low_impact	-0.09	medium_impact	2.25	high_impact	0.37	0.8	20.07	7.26	0.48	P	0.95	disease_causing	0.91	0.28	.	.	.	.	.	.	COSM6716771	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14081	14081	G	T	MI.22966	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1745	582	G	V	gGc/gTc	2.92	1	0	probably_damaging	0.99	neutral	0.5	neutral	0.67	deleterious	-3.53	deleterious	-7.9	high_impact	3.78	0.63	neutral	0.28	neutral	3.93	23.50	deleterious	0.28	0.45	0.85	disease	0.88	disease	0.72	disease	0.81	disease	6	0.99	deleterious	0.26	neutral	2	deleterious	0.90	deleterious	-2.64	low_impact	0.23	medium_impact	2.25	high_impact	0.34	0.8	20.07	7.26	0.43	N	0.98	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14081	14081	G	C	MI.22967	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1745	582	G	A	gGc/gCc	2.92	1	0	probably_damaging	0.95	neutral	0.51	neutral	0.73	neutral	-2.18	deleterious	-5.25	medium_impact	2.58	0.67	neutral	0.59	neutral	3.27	22.80	deleterious	0.34	0.5	0.69	disease	0.61	disease	0.67	disease	0.52	disease	0	0.94	neutral	0.28	neutral	1	deleterious	0.83	deleterious	-1.96	low_impact	0.24	medium_impact	1.15	medium_impact	0.53	0.8	20.07	7.26	0.36	N	0.79	disease_causing	0.74	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14083	14083	A	G	MI.22968	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1747	583	M	V	Ata/Gta	-14.5	0	0	benign	0.26	neutral	0.51	neutral	1.02	neutral	0.49	neutral	-1.38	low_impact	1.38	0.77	neutral	0.75	neutral	1.02	10.75	neutral	0.67	0.7	0.41	neutral	0.72	disease	0.53	disease	0.56	disease	1	0.39	neutral	0.63	deleterious	-6	neutral	0.25	neutral	-0.32	medium_impact	0.24	medium_impact	0.06	medium_impact	0.65	0.8	15.75	12.27	0.24	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14083	14083	A	T	MI.22969	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1747	583	M	L	Ata/Tta	-14.5	0	0	benign	0.01	neutral	0.68	neutral	1.23	neutral	2.38	neutral	0.83	neutral_impact	-0.84	0.81	neutral	0.98	neutral	-1.06	0.01	neutral	0.62	0.65	0.21	neutral	0.29	neutral	0.44	neutral	0.44	neutral	1	0.29	neutral	0.84	deleterious	-6	neutral	0.12	neutral	1.15	medium_impact	0.41	medium_impact	-1.97	low_impact	0.65	0.8	15.75	12.27	0.31	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6100	6100	T	A	MI.2297	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	197	66	I	N	aTc/aAc	8.69	1	0	possibly_damaging	0.53	deleterious	0	neutral	2.34	deleterious	-6.62	deleterious	-4.36	high_impact	5.08	0.61	neutral	0.07	damaging	4.50	24.30	deleterious	0.22	0.55	0.91	disease	0.71	disease	0.61	disease	0.76	disease	5	1	deleterious	0.24	neutral	5	deleterious	0.67	deleterious	-0.81	medium_impact	-1.48	low_impact	3.59	high_impact	0.65	0.9	2.53	6.64	0.62	P	0.94	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14083	14083	A	C	MI.22970	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1747	583	M	L	Ata/Cta	-14.5	0	0	benign	0.01	neutral	0.68	neutral	1.23	neutral	2.38	neutral	0.83	neutral_impact	-0.84	0.81	neutral	0.98	neutral	-1.17	0.01	neutral	0.62	0.65	0.21	neutral	0.29	neutral	0.44	neutral	0.44	neutral	1	0.29	neutral	0.84	deleterious	-6	neutral	0.12	neutral	1.15	medium_impact	0.41	medium_impact	-1.97	low_impact	0.65	0.8	15.75	12.27	0.31	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14084	14084	T	C	MI.22971	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1748	583	M	T	aTa/aCa	-3.73	0	0	possibly_damaging	0.64	neutral	0.43	neutral	1.02	neutral	0.49	deleterious	-2.98	low_impact	1.27	0.77	neutral	0.76	neutral	1.41	12.86	neutral	0.52	0.6	0.42	neutral	0.68	disease	0.66	disease	0.55	disease	1	0.65	neutral	0.4	neutral	-3	neutral	0.44	deleterious	-0.98	medium_impact	0.17	medium_impact	-0.04	medium_impact	0.23	0.8	15.75	12.27	0.26	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14084	14084	T	A	MI.22972	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1748	583	M	K	aTa/aAa	-3.73	0	0	possibly_damaging	0.71	neutral	0.3	neutral	1	neutral	0.11	deleterious	-3.67	low_impact	1.03	0.76	neutral	0.69	neutral	2.50	19.47	deleterious	0.3	0.45	0.25	neutral	0.87	disease	0.73	disease	0.77	disease	5	0.78	neutral	0.3	neutral	-3	neutral	0.53	deleterious	-1.12	low_impact	0.03	medium_impact	-0.26	medium_impact	0.61	0.8	15.75	12.27	0.28	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14085	14085	A	C	MI.22973	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1749	583	M	I	atA/atC	0.4	0	0	benign	0.25	neutral	0.41	neutral	1	neutral	-0.04	neutral	-0.71	low_impact	1.58	0.75	neutral	0.75	neutral	1.65	14.13	neutral	0.59	0.65	0.41	neutral	0.71	disease	0.52	disease	0.54	disease	1	0.5	neutral	0.58	deleterious	-6	neutral	0.27	neutral	-0.29	medium_impact	0.15	medium_impact	0.24	medium_impact	0.56	0.8	15.75	12.27	0.34	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14085	14085	A	T	MI.22974	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1749	583	M	I	atA/atT	0.4	0	0	benign	0.25	neutral	0.41	neutral	1	neutral	-0.04	neutral	-0.71	low_impact	1.58	0.75	neutral	0.75	neutral	1.71	14.45	neutral	0.59	0.65	0.41	neutral	0.71	disease	0.52	disease	0.54	disease	1	0.5	neutral	0.58	deleterious	-6	neutral	0.27	neutral	-0.29	medium_impact	0.15	medium_impact	0.24	medium_impact	0.56	0.8	15.75	12.27	0.34	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14086	14086	A	T	MI.22975	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1750	584	I	F	Att/Ttt	-0.29	0	0	probably_damaging	0.97	neutral	0.73	neutral	0.68	neutral	-2.55	deleterious	-3.34	medium_impact	2.88	0.62	neutral	0.36	neutral	3.88	23.50	deleterious	0.47	0.55	0.48	neutral	0.88	disease	0.64	disease	0.74	disease	5	0.97	neutral	0.38	neutral	1	deleterious	0.80	deleterious	-2.18	low_impact	0.47	medium_impact	1.43	medium_impact	0.58	0.8	NA	NA	0.22	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14086	14086	A	C	MI.22976	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1750	584	I	L	Att/Ctt	-0.29	0	0	possibly_damaging	0.61	neutral	0.91	neutral	0.93	neutral	0.25	neutral	-1.48	medium_impact	2.37	0.74	neutral	0.83	neutral	2.83	21.50	deleterious	0.42	0.55	0.36	neutral	0.74	disease	0.44	neutral	0.53	disease	1	0.56	neutral	0.65	deleterious	0	NA	0.72	deleterious	-0.93	medium_impact	0.79	medium_impact	0.96	medium_impact	0.51	0.8	NA	NA	0.28	N	0.67	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14086	14086	A	G	MI.22977	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1750	584	I	V	Att/Gtt	-0.29	0	0	benign	0.18	neutral	0.53	neutral	0.73	neutral	-0.23	neutral	-0.69	medium_impact	2.02	0.83	neutral	0.96	neutral	2.02	16.36	deleterious	0.59	0.65	0.31	neutral	0.41	neutral	0.49	neutral	0.4	neutral	2	0.36	neutral	0.68	deleterious	-3	neutral	0.67	deleterious	-0.12	medium_impact	0.26	medium_impact	0.64	medium_impact	0.41	0.8	NA	NA	0.33	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14087	14087	T	A	MI.22978	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1751	584	I	N	aTt/aAt	0.86	0.19	0	probably_damaging	0.98	neutral	0.34	neutral	0.6	deleterious	-4.68	deleterious	-5.87	medium_impact	3.23	0.62	neutral	0.41	neutral	4.65	24.50	deleterious	0.41	0.5	0.83	disease	0.9	disease	0.7	disease	0.78	disease	6	0.99	deleterious	0.18	neutral	1	deleterious	0.86	deleterious	-2.35	low_impact	0.07	medium_impact	1.75	medium_impact	0.53	0.8	NA	NA	0.31	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14087	14087	T	C	MI.22979	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1751	584	I	T	aTt/aCt	0.86	0.19	0	probably_damaging	0.91	neutral	0.56	neutral	0.63	deleterious	-3.02	deleterious	-4.05	medium_impact	3.02	0.64	neutral	0.52	neutral	3.59	23.20	deleterious	0.5	0.6	0.51	disease	0.77	disease	0.67	disease	0.66	disease	3	0.9	neutral	0.33	neutral	1	deleterious	0.80	deleterious	-1.7	low_impact	0.29	medium_impact	1.56	medium_impact	0.48	0.8	NA	NA	0.24	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6101	6101	C	A	MI.2298	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	198	66	I	M	atC/atA	5.91	1	0	possibly_damaging	0.75	deleterious	0	neutral	2.4	deleterious	-3.69	neutral	-1.7	high_impact	3.83	0.66	neutral	0.07	damaging	3.66	23.20	deleterious	0.33	0.55	0.45	neutral	0.57	disease	0.52	disease	0.49	neutral	0	1	deleterious	0.13	neutral	5	deleterious	0.63	deleterious	-1.21	low_impact	-1.48	low_impact	2.44	high_impact	0.80	0.9	2.53	6.64	0.5	N	0.76	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14087	14087	T	G	MI.22980	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1751	584	I	S	aTt/aGt	0.86	0.19	0	probably_damaging	0.96	neutral	0.55	neutral	0.62	deleterious	-3.65	deleterious	-4.98	medium_impact	3.23	0.63	neutral	0.48	neutral	4.41	24.10	deleterious	0.36	0.5	0.6	disease	0.88	disease	0.69	disease	0.76	disease	5	0.95	neutral	0.3	neutral	1	deleterious	0.84	deleterious	-2.06	low_impact	0.28	medium_impact	1.75	medium_impact	0.46	0.8	NA	NA	0.26	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14088	14088	T	A	MI.22981	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1752	584	I	M	atT/atA	5.67	0.88	0	probably_damaging	0.97	neutral	0.23	neutral	0.69	neutral	-2.39	neutral	-2.19	low_impact	1.3	0.77	neutral	0.96	neutral	2.74	21.00	deleterious	0.62	0.65	0.7	disease	0.65	disease	0.46	neutral	0.52	disease	0	0.98	neutral	0.13	neutral	-2	neutral	0.77	deleterious	-2.18	low_impact	-0.06	medium_impact	-0.02	medium_impact	0.59	0.8	NA	NA	0.42	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14088	14088	T	G	MI.22982	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1752	584	I	M	atT/atG	5.67	0.88	0	probably_damaging	0.97	neutral	0.23	neutral	0.69	neutral	-2.39	neutral	-2.19	low_impact	1.3	0.77	neutral	0.96	neutral	2.49	19.41	deleterious	0.62	0.65	0.7	disease	0.65	disease	0.46	neutral	0.52	disease	0	0.98	neutral	0.13	neutral	-2	neutral	0.77	deleterious	-2.18	low_impact	-0.06	medium_impact	-0.02	medium_impact	0.59	0.8	NA	NA	0.41	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14089	14089	A	C	MI.22983	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1753	585	K	Q	Aaa/Caa	-6.02	0	0	probably_damaging	1	neutral	0.68	neutral	0.25	deleterious	-4.03	deleterious	-3.55	medium_impact	3.34	0.53	damaging	0.12	damaging	3.56	23.10	deleterious	0.41	0.5	0.33	neutral	0.79	disease	0.71	disease	0.72	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.41	medium_impact	1.85	medium_impact	0.64	0.8	28.03	7.12	0.25	N	0.82	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14089	14089	A	G	MI.22984	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1753	585	K	E	Aaa/Gaa	-6.02	0	0	probably_damaging	1	neutral	1	neutral	0.27	deleterious	-3.63	deleterious	-3.55	high_impact	3.88	0.59	damaging	0.12	damaging	4.16	23.80	deleterious	0.38	0.5	0.46	neutral	0.84	disease	0.77	disease	0.79	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.81	deleterious	-3.6	low_impact	1.89	high_impact	2.34	high_impact	0.79	0.85	28.03	7.12	0.3	N	0.84	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14090	14090	A	C	MI.22985	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1754	585	K	T	aAa/aCa	6.59	1	0	probably_damaging	1	neutral	0.77	neutral	0.26	deleterious	-3.94	deleterious	-5.32	high_impact	3.54	0.52	damaging	0.11	damaging	3.77	23.40	deleterious	0.23	0.45	0.54	disease	0.81	disease	0.72	disease	0.74	disease	5	1	deleterious	0.39	neutral	2	deleterious	0.82	deleterious	-3.6	low_impact	0.52	medium_impact	2.03	high_impact	0.49	0.8	28.03	7.12	0.45	N	0.75	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14090	14090	A	T	MI.22986	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1754	585	K	M	aAa/aTa	6.59	1	0	probably_damaging	1	neutral	0.25	neutral	0.24	deleterious	-4.5	deleterious	-5.32	medium_impact	3.34	0.58	damaging	0.08	damaging	4.08	23.70	deleterious	0.28	0.45	0.81	disease	0.82	disease	0.72	disease	0.77	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.03	medium_impact	1.85	medium_impact	0.45	0.8	28.03	7.12	0.48	N	0.40	disease_causing	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14091	14091	A	C	MI.22987	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1755	585	K	N	aaA/aaC	6.59	1	0.01	probably_damaging	1	neutral	0.64	neutral	0.25	deleterious	-4.05	deleterious	-4.43	medium_impact	3.19	0.49	damaging	0.12	damaging	3.96	23.60	deleterious	0.52	0.6	0.58	disease	0.82	disease	0.75	disease	0.76	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.37	medium_impact	1.71	medium_impact	0.73	0.85	28.03	7.12	0.55	P	0.63	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14091	14091	A	T	MI.22988	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1755	585	K	N	aaA/aaT	6.59	1	0.01	probably_damaging	1	neutral	0.64	neutral	0.25	deleterious	-4.05	deleterious	-4.43	medium_impact	3.19	0.49	damaging	0.12	damaging	4.01	23.60	deleterious	0.52	0.6	0.58	disease	0.82	disease	0.75	disease	0.76	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.37	medium_impact	1.71	medium_impact	0.73	0.85	28.03	7.12	0.57	P	0.63	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	A14091T	Developmental delay, seizure, hearing loss, diabetes	-	+	Reported	1	.	P	P	damaging
chrM	14092	14092	C	A	MI.22989	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1756	586	L	I	Ctt/Att	0.86	0.25	0	probably_damaging	1	neutral	0.37	neutral	1.11	neutral	0.7	neutral	-1.43	neutral_impact	0.64	0.82	neutral	0.48	neutral	3.19	22.70	deleterious	0.38	0.5	0.48	neutral	0.36	neutral	0.3	neutral	0.43	neutral	1	1	deleterious	0.19	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.11	medium_impact	-0.62	medium_impact	0.80	0.85	18.24	14.19	0.26	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6101	6101	C	G	MI.2299	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	198	66	I	M	atC/atG	5.91	1	0	possibly_damaging	0.75	deleterious	0	neutral	2.4	deleterious	-3.69	neutral	-1.7	high_impact	3.83	0.66	neutral	0.07	damaging	3.25	22.80	deleterious	0.33	0.55	0.45	neutral	0.57	disease	0.52	disease	0.49	neutral	0	1	deleterious	0.13	neutral	5	deleterious	0.63	deleterious	-1.21	low_impact	-1.48	low_impact	2.44	high_impact	0.80	0.9	2.53	6.64	0.49	N	0.76	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14092	14092	C	G	MI.22990	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1756	586	L	V	Ctt/Gtt	0.86	0.25	0	probably_damaging	1	neutral	0.5	neutral	0.96	neutral	-0.4	neutral	-2.29	low_impact	1.4	0.82	neutral	0.43	neutral	2.37	18.63	deleterious	0.48	0.55	0.37	neutral	0.4	neutral	0.34	neutral	0.46	neutral	1	1	deleterious	0.25	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.23	medium_impact	0.08	medium_impact	0.68	0.85	18.24	14.19	0.25	N	0.35	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14092	14092	C	T	MI.22991	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1756	586	L	F	Ctt/Ttt	0.86	0.25	0	probably_damaging	1	neutral	0.41	neutral	0.85	neutral	-2.23	deleterious	-2.77	low_impact	1.88	0.8	neutral	0.77	neutral	2.95	22.10	deleterious	0.39	0.5	0.54	disease	0.55	disease	0.37	neutral	0.51	disease	0	1	deleterious	0.21	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.15	medium_impact	0.51	medium_impact	0.70	0.85	18.24	14.19	0.26	N	0.84	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14093	14093	T	C	MI.22992	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1757	586	L	P	cTt/cCt	-2.12	0	0	probably_damaging	1	neutral	0.34	neutral	0.84	deleterious	-3.03	deleterious	-5.81	low_impact	1.63	0.77	neutral	0.41	neutral	4.01	23.60	deleterious	0.17	0.45	0.78	disease	0.84	disease	0.67	disease	0.79	disease	6	1	deleterious	0.17	neutral	-2	neutral	0.88	deleterious	-3.6	low_impact	0.07	medium_impact	0.29	medium_impact	0.49	0.8	18.24	14.19	0.23	N	0.90	polymorphism	1	0.12	.	.	.	.	.	.	COSM6716772	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14093	14093	T	A	MI.22993	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1757	586	L	H	cTt/cAt	-2.12	0	0	probably_damaging	1	neutral	0.39	neutral	0.83	deleterious	-3.29	deleterious	-5.65	medium_impact	2.08	0.68	neutral	0.19	damaging	4.46	24.20	deleterious	0.27	0.45	0.65	disease	0.63	disease	0.46	neutral	0.51	disease	0	1	deleterious	0.2	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.13	medium_impact	0.7	medium_impact	0.65	0.8	18.24	14.19	0.25	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14093	14093	T	G	MI.22994	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1757	586	L	R	cTt/cGt	-2.12	0	0	probably_damaging	1	neutral	0.63	neutral	0.86	neutral	-1.92	deleterious	-5	medium_impact	2.44	0.65	neutral	0.14	damaging	4.30	24.00	deleterious	0.28	0.45	0.66	disease	0.87	disease	0.66	disease	0.81	disease	6	1	deleterious	0.32	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.36	medium_impact	1.03	medium_impact	0.70	0.85	18.24	14.19	0.18	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14095	14095	T	G	MI.22995	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1759	587	Y	D	Tac/Gac	-20	0	0	probably_damaging	1	neutral	0.2	neutral	0.23	deleterious	-5.72	deleterious	-8.86	high_impact	3.8	0.66	neutral	0.16	damaging	4.03	23.60	deleterious	0.31	0.5	0.85	disease	0.88	disease	0.82	disease	0.88	disease	8	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.1	medium_impact	2.27	high_impact	0.46	0.8	NA	NA	0.39	N	0.96	polymorphism	0.96	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14095	14095	T	C	MI.22996	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1759	587	Y	H	Tac/Cac	-20	0	0	probably_damaging	1	neutral	0.46	neutral	0.28	deleterious	-3.85	deleterious	-4.43	medium_impact	2.48	0.65	neutral	0.19	damaging	3.66	23.20	deleterious	0.45	0.55	0.78	disease	0.81	disease	0.81	disease	0.78	disease	6	1	deleterious	0.23	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.19	medium_impact	1.06	medium_impact	0.65	0.8	NA	NA	0.25	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14095	14095	T	A	MI.22997	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1759	587	Y	N	Tac/Aac	-20	0	0	probably_damaging	1	neutral	0.33	neutral	0.24	deleterious	-5.11	deleterious	-7.97	high_impact	3.8	0.63	neutral	0.15	damaging	4.10	23.70	deleterious	0.36	0.5	0.85	disease	0.86	disease	0.76	disease	0.82	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	0.06	medium_impact	2.27	high_impact	0.50	0.8	NA	NA	0.36	N	0.99	polymorphism	0.95	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14096	14096	A	C	MI.22998	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1760	587	Y	S	tAc/tCc	4.52	1	0	probably_damaging	1	neutral	0.4	neutral	0.28	deleterious	-4.68	deleterious	-7.97	medium_impact	3.1	0.66	neutral	0.15	damaging	3.83	23.40	deleterious	0.34	0.5	0.72	disease	0.83	disease	0.75	disease	0.79	disease	6	1	deleterious	0.2	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.14	medium_impact	1.63	medium_impact	0.54	0.8	NA	NA	0.4	N	0.97	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14096	14096	A	T	MI.22999	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1760	587	Y	F	tAc/tTc	4.52	1	0	probably_damaging	1	neutral	0.7	neutral	0.33	neutral	-1.88	deleterious	-3.54	medium_impact	2.52	0.65	neutral	0.24	damaging	3.50	23.10	deleterious	0.53	0.6	0.83	disease	0.78	disease	0.72	disease	0.69	disease	4	1	deleterious	0.35	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	0.44	medium_impact	1.1	medium_impact	0.50	0.8	NA	NA	0.39	N	0.80	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8536	8536	A	G	MI.23	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	10	4	N	D	Aat/Gat	6.84	1	0	benign	0	neutral	0.38	neutral	4.5	neutral	-0.73	deleterious	-3.21	medium_impact	2.3	0.86	neutral	0.49	neutral	1.53	13.48	neutral	0.77	0.8	0.77	disease	0.35	neutral	0.36	neutral	0.65	disease	3	0.62	neutral	0.69	deleterious	-3	neutral	0.17	neutral	2.09	high_impact	0.17	medium_impact	0.87	medium_impact	0.39	0.9	41.59	7.51	0.6	P	0.88	disease_causing	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8635	8635	C	G	MI.230	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	109	37	L	V	Ctc/Gtc	-1.26	0	0	benign	0.39	neutral	0.17	neutral	4.33	neutral	-0.86	neutral	-1.91	low_impact	1.47	0.87	neutral	0.53	neutral	1.54	13.54	neutral	0.49	0.65	0.52	disease	0.4	neutral	0.54	disease	0.5	neutral	0	0.8	neutral	0.39	neutral	-6	neutral	0.42	neutral	-0.57	medium_impact	-0.1	medium_impact	0.16	medium_impact	0.45	0.9	20.35	20.89	0.4	N	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6102	6102	T	C	MI.2300	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	199	67	F	L	Ttc/Ctc	-1.49	0	0	benign	0.13	deleterious	0	neutral	2.42	neutral	-2.22	deleterious	-3.86	medium_impact	3.04	0.66	neutral	0.15	damaging	3.95	23.60	deleterious	0.33	0.55	0.33	neutral	0.78	disease	0.59	disease	0.65	disease	3	1	deleterious	0.44	neutral	1	deleterious	0.25	neutral	0.02	medium_impact	-1.48	low_impact	1.71	medium_impact	0.56	0.9	1.17	6.64	0.35	N	0.83	disease_causing	0.55	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14096	14096	A	G	MI.23000	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1760	587	Y	C	tAc/tGc	4.52	1	0	probably_damaging	1	neutral	0.16	neutral	0.23	deleterious	-6.53	deleterious	-7.97	high_impact	3.8	0.61	neutral	0.14	damaging	3.66	23.20	deleterious	0.33	0.5	0.95	disease	0.87	disease	0.8	disease	0.89	disease	8	1	deleterious	0.08	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.17	medium_impact	2.27	high_impact	0.28	0.8	NA	NA	0.48	N	1.00	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14098	14098	T	C	MI.23001	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1762	588	F	L	Ttc/Ctc	-1.89	0	0	benign	0.17	neutral	0.66	neutral	1.89	neutral	3.27	deleterious	-4.9	neutral_impact	0.03	0.76	neutral	0.78	neutral	0.46	7.13	deleterious	0.31	0.45	0.19	neutral	0.23	neutral	0.39	neutral	0.41	neutral	2	0.22	neutral	0.75	deleterious	-6	neutral	0.27	neutral	-0.09	medium_impact	0.39	medium_impact	-1.18	low_impact	0.79	0.85	5.14	9.29	0.37	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14098	14098	T	A	MI.23002	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1762	588	F	I	Ttc/Atc	-1.89	0	0	benign	0.17	neutral	0.4	neutral	1.07	neutral	0.58	deleterious	-4.9	medium_impact	2.14	0.75	neutral	0.68	neutral	2.86	21.60	deleterious	0.16	0.45	0.44	neutral	0.72	disease	0.56	disease	0.67	disease	3	0.52	neutral	0.62	deleterious	-3	neutral	0.36	neutral	-0.09	medium_impact	0.14	medium_impact	0.75	medium_impact	0.70	0.85	5.14	9.29	0.34	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14098	14098	T	G	MI.23003	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1762	588	F	V	Ttc/Gtc	-1.89	0	0	benign	0.17	neutral	0.5	neutral	0.96	neutral	-0.4	deleterious	-5.72	medium_impact	2.29	0.73	neutral	0.7	neutral	2.48	19.35	deleterious	0.2	0.45	0.35	neutral	0.81	disease	0.57	disease	0.76	disease	5	0.4	neutral	0.67	deleterious	-3	neutral	0.35	neutral	-0.09	medium_impact	0.23	medium_impact	0.89	medium_impact	0.70	0.85	5.14	9.29	0.33	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14099	14099	T	C	MI.23004	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1763	588	F	S	tTc/tCc	0.4	0	0	benign	0.17	neutral	0.41	neutral	0.86	deleterious	-3.75	deleterious	-6.15	medium_impact	2.14	0.85	neutral	0.76	neutral	2.49	19.42	deleterious	0.19	0.45	0.57	disease	0.72	disease	0.58	disease	0.69	disease	4	0.51	neutral	0.62	deleterious	-3	neutral	0.39	neutral	-0.09	medium_impact	0.15	medium_impact	0.75	medium_impact	0.59	0.8	5.14	9.29	0.32	N	0.53	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14099	14099	T	A	MI.23005	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1763	588	F	Y	tTc/tAc	0.4	0	0	benign	0.17	neutral	1	neutral	0.86	deleterious	-3.71	neutral	-2.45	medium_impact	2.84	0.68	neutral	0.61	neutral	2.57	19.92	deleterious	0.22	0.45	0.55	disease	0.7	disease	0.61	disease	0.73	disease	5	0.17	neutral	0.92	deleterious	-3	neutral	0.40	neutral	-0.09	medium_impact	1.89	high_impact	1.39	medium_impact	0.75	0.85	5.14	9.29	0.21	N	0.72	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14099	14099	T	G	MI.23006	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1763	588	F	C	tTc/tGc	0.4	0	0	benign	0.17	neutral	0.18	neutral	0.86	deleterious	-4.47	deleterious	-6.47	medium_impact	2.84	0.64	neutral	0.57	neutral	2.41	18.90	deleterious	0.19	0.45	0.63	disease	0.85	disease	0.64	disease	0.78	disease	6	0.79	neutral	0.51	deleterious	-3	neutral	0.40	neutral	-0.09	medium_impact	-0.13	medium_impact	1.39	medium_impact	0.46	0.8	5.14	9.29	0.31	N	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14100	14100	C	A	MI.23007	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1764	588	F	L	ttC/ttA	1.77	0.01	0	benign	0.17	neutral	0.66	neutral	1.89	neutral	3.27	deleterious	-4.9	neutral_impact	0.03	0.76	neutral	0.78	neutral	0.99	10.58	neutral	0.31	0.45	0.19	neutral	0.23	neutral	0.39	neutral	0.41	neutral	2	0.22	neutral	0.75	deleterious	-6	neutral	0.27	neutral	-0.09	medium_impact	0.39	medium_impact	-1.18	low_impact	0.79	0.85	5.14	9.29	0.41	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14100	14100	C	G	MI.23008	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1764	588	F	L	ttC/ttG	1.77	0.01	0	benign	0.17	neutral	0.66	neutral	1.89	neutral	3.27	deleterious	-4.9	neutral_impact	0.03	0.76	neutral	0.78	neutral	0.66	8.54	deleterious	0.31	0.45	0.19	neutral	0.23	neutral	0.39	neutral	0.41	neutral	2	0.22	neutral	0.75	deleterious	-6	neutral	0.27	neutral	-0.09	medium_impact	0.39	medium_impact	-1.18	low_impact	0.79	0.85	5.14	9.29	0.4	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14101	14101	C	G	MI.23009	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1765	589	L	V	Ctc/Gtc	-4.87	0	0	possibly_damaging	0.54	neutral	0.49	neutral	0.82	neutral	-1.27	neutral	-2.21	low_impact	1.49	0.75	neutral	0.73	neutral	3.13	22.60	deleterious	0.3	0.45	0.48	neutral	0.42	neutral	0.39	neutral	0.43	neutral	1	0.53	neutral	0.48	deleterious	-3	neutral	0.49	deleterious	-0.81	medium_impact	0.22	medium_impact	0.16	medium_impact	0.75	0.85	3.81	8.29	0.31	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6102	6102	T	A	MI.2301	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	199	67	F	I	Ttc/Atc	-1.49	0	0	benign	0.04	deleterious	0	neutral	2.32	deleterious	-3.31	deleterious	-3.86	high_impact	4.22	0.62	neutral	0.2	damaging	4.27	23.90	deleterious	0.19	0.55	0.44	neutral	0.91	disease	0.64	disease	0.74	disease	5	1	deleterious	0.48	deleterious	2	deleterious	0.27	neutral	0.54	medium_impact	-1.48	low_impact	2.8	high_impact	0.58	0.9	1.17	6.64	0.41	N	0.88	disease_causing	0.53	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14101	14101	C	A	MI.23010	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1765	589	L	I	Ctc/Atc	-4.87	0	0	possibly_damaging	0.54	neutral	0.4	neutral	0.81	neutral	-1.35	neutral	-1.48	low_impact	1.69	0.79	neutral	0.79	neutral	3.77	23.40	deleterious	0.26	0.45	0.55	disease	0.4	neutral	0.36	neutral	0.6	disease	2	0.6	neutral	0.43	neutral	-3	neutral	0.49	deleterious	-0.81	medium_impact	0.14	medium_impact	0.34	medium_impact	0.77	0.85	3.81	8.29	0.32	N	0.56	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14101	14101	C	T	MI.23011	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1765	589	L	F	Ctc/Ttc	-4.87	0	0	possibly_damaging	0.54	neutral	0.71	neutral	0.75	neutral	-2.21	deleterious	-3.12	medium_impact	2.03	0.79	neutral	0.7	neutral	3.67	23.30	deleterious	0.31	0.45	0.45	neutral	0.53	disease	0.49	neutral	0.49	neutral	0	0.44	neutral	0.59	deleterious	0	NA	0.49	deleterious	-0.81	medium_impact	0.45	medium_impact	0.65	medium_impact	0.68	0.85	3.81	8.29	0.22	N	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14102	14102	T	C	MI.23012	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1766	589	L	P	cTc/cCc	-2.35	0	0	possibly_damaging	0.54	neutral	0.2	neutral	0.69	deleterious	-4.4	deleterious	-5.59	medium_impact	2.38	0.6	neutral	0.52	neutral	3.59	23.20	deleterious	0.12	0.4	0.85	disease	0.84	disease	0.65	disease	0.79	disease	6	0.79	neutral	0.33	neutral	0	NA	0.65	deleterious	-0.81	medium_impact	-0.1	medium_impact	0.97	medium_impact	0.62	0.8	3.81	8.29	0.26	N	0.95	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14102	14102	T	A	MI.23013	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1766	589	L	H	cTc/cAc	-2.35	0	0	possibly_damaging	0.54	neutral	0.53	neutral	0.69	deleterious	-4.34	deleterious	-5.59	medium_impact	2.73	0.76	neutral	0.6	neutral	3.81	23.40	deleterious	0.12	0.4	0.84	disease	0.67	disease	0.61	disease	0.74	disease	5	0.51	neutral	0.5	deleterious	0	NA	0.57	deleterious	-0.81	medium_impact	0.26	medium_impact	1.29	medium_impact	0.58	0.8	3.81	8.29	0.24	N	0.86	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14102	14102	T	G	MI.23014	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1766	589	L	R	cTc/cGc	-2.35	0	0	possibly_damaging	0.54	neutral	0.36	neutral	0.7	deleterious	-3.75	deleterious	-4.75	medium_impact	2.73	0.71	neutral	0.53	neutral	3.91	23.50	deleterious	0.1	0.4	0.79	disease	0.86	disease	0.64	disease	0.78	disease	6	0.63	neutral	0.41	neutral	0	NA	0.63	deleterious	-0.81	medium_impact	0.1	medium_impact	1.29	medium_impact	0.51	0.8	3.81	8.29	0.28	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14104	14104	T	C	MI.23015	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1768	590	S	P	Tct/Cct	-3.27	0	0	possibly_damaging	0.54	neutral	0.19	neutral	0.74	deleterious	-4.14	deleterious	-4.28	medium_impact	2.99	0.61	neutral	0.15	damaging	3.62	23.20	deleterious	0.17	0.45	0.77	disease	0.9	disease	0.67	disease	0.78	disease	6	0.8	neutral	0.33	neutral	0	NA	0.57	deleterious	-0.81	medium_impact	-0.12	medium_impact	1.53	medium_impact	0.81	0.85	8.96	7.19	0.27	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14104	14104	T	G	MI.23016	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1768	590	S	A	Tct/Gct	-3.27	0	0	possibly_damaging	0.54	neutral	0.51	neutral	0.82	neutral	-1.64	deleterious	-2.56	low_impact	1.8	0.77	neutral	0.42	neutral	2.12	16.98	deleterious	0.46	0.55	0.48	neutral	0.46	neutral	0.49	neutral	0.45	neutral	1	0.52	neutral	0.49	deleterious	-3	neutral	0.43	neutral	-0.81	medium_impact	0.24	medium_impact	0.44	medium_impact	0.72	0.85	8.96	7.19	0.24	N	0.49	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14104	14104	T	A	MI.23017	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1768	590	S	T	Tct/Act	-3.27	0	0	possibly_damaging	0.54	neutral	0.42	neutral	0.83	neutral	-1.48	neutral	-2.29	neutral_impact	0.53	0.81	neutral	0.61	neutral	2.09	16.79	deleterious	0.31	0.45	0.38	neutral	0.25	neutral	0.41	neutral	0.44	neutral	1	0.58	neutral	0.44	neutral	-3	neutral	0.40	neutral	-0.81	medium_impact	0.16	medium_impact	-0.72	medium_impact	0.81	0.85	8.96	7.19	0.29	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14105	14105	C	T	MI.23018	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1769	590	S	F	tCt/tTt	-0.06	0	0	possibly_damaging	0.54	neutral	0.74	neutral	0.82	neutral	-1.61	deleterious	-5.17	medium_impact	2.3	0.76	neutral	0.24	damaging	2.78	21.30	deleterious	0.22	0.45	0.37	neutral	0.82	disease	0.5	neutral	0.69	disease	4	0.44	neutral	0.6	deleterious	0	NA	0.44	deleterious	-0.81	medium_impact	0.48	medium_impact	0.9	medium_impact	0.46	0.8	8.96	7.19	0.2	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14105	14105	C	G	MI.23019	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1769	590	S	C	tCt/tGt	-0.06	0	0	possibly_damaging	0.54	neutral	0.17	neutral	0.76	deleterious	-3.09	deleterious	-4.28	medium_impact	2.99	0.66	neutral	0.19	damaging	3.28	22.80	deleterious	0.22	0.45	0.79	disease	0.79	disease	0.53	disease	0.74	disease	5	0.82	neutral	0.32	neutral	0	NA	0.48	deleterious	-0.81	medium_impact	-0.15	medium_impact	1.53	medium_impact	0.72	0.85	8.96	7.19	0.3	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6102	6102	T	G	MI.2302	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	199	67	F	V	Ttc/Gtc	-1.49	0	0	benign	0.35	deleterious	0	neutral	2.35	neutral	-2.93	deleterious	-4.5	high_impact	5.12	0.63	neutral	0.15	damaging	3.95	23.60	deleterious	0.2	0.55	0.65	disease	0.91	disease	0.67	disease	0.76	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.36	neutral	-0.5	medium_impact	-1.48	low_impact	3.63	high_impact	0.60	0.9	1.17	6.64	0.61	P	0.84	disease_causing	0.71	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14105	14105	C	A	MI.23020	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1769	590	S	Y	tCt/tAt	-0.06	0	0	possibly_damaging	0.54	neutral	1	neutral	0.76	deleterious	-3.14	deleterious	-5.17	medium_impact	2.99	0.75	neutral	0.16	damaging	3.78	23.40	deleterious	0.21	0.45	0.44	neutral	0.83	disease	0.63	disease	0.77	disease	5	0.54	neutral	0.73	deleterious	0	NA	0.47	deleterious	-0.81	medium_impact	1.89	high_impact	1.53	medium_impact	0.71	0.85	8.96	7.19	0.21	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14107	14107	T	A	MI.23021	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1771	591	F	I	Ttc/Atc	-14.5	0	0	benign	0.17	neutral	0.93	neutral	0.57	neutral	-2.49	deleterious	-5	medium_impact	2.29	0.75	neutral	0.33	neutral	2.74	21.00	deleterious	0.19	0.45	0.26	neutral	0.81	disease	0.67	disease	0.6	disease	2	0.08	neutral	0.88	deleterious	-3	neutral	0.35	neutral	-0.09	medium_impact	0.85	medium_impact	0.89	medium_impact	0.70	0.85	NA	NA	0.28	N	0.95	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14107	14107	T	C	MI.23022	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1771	591	F	L	Ttc/Ctc	-14.5	0	0	benign	0.17	neutral	1	neutral	0.61	neutral	-2.03	deleterious	-4.96	medium_impact	2.27	0.75	neutral	0.36	neutral	2.35	18.49	deleterious	0.42	0.55	0.36	neutral	0.75	disease	0.64	disease	0.58	disease	2	0.17	neutral	0.92	deleterious	-3	neutral	0.35	neutral	-0.09	medium_impact	1.89	high_impact	0.87	medium_impact	0.63	0.8	NA	NA	0.25	N	0.92	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14107	14107	T	G	MI.23023	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1771	591	F	V	Ttc/Gtc	-14.5	0	0	benign	0.17	neutral	0.48	neutral	0.59	neutral	-2.25	deleterious	-5.81	medium_impact	3.39	0.71	neutral	0.18	damaging	2.43	19.01	deleterious	0.26	0.45	0.4	neutral	0.86	disease	0.74	disease	0.77	disease	5	0.43	neutral	0.66	deleterious	-3	neutral	0.38	neutral	-0.09	medium_impact	0.21	medium_impact	1.89	medium_impact	0.66	0.8	NA	NA	0.33	N	0.95	polymorphism	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14108	14108	T	A	MI.23024	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1772	591	F	Y	tTc/tAc	5.67	1	0	benign	0.17	neutral	0.7	neutral	0.5	deleterious	-4.03	deleterious	-2.59	medium_impact	3.04	0.76	neutral	0.27	damaging	2.54	19.70	deleterious	0.33	0.5	0.45	neutral	0.75	disease	0.68	disease	0.65	disease	3	0.18	neutral	0.77	deleterious	-3	neutral	0.38	neutral	-0.09	medium_impact	0.44	medium_impact	1.57	medium_impact	0.71	0.85	NA	NA	0.48	N	0.88	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14108	14108	T	C	MI.23025	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1772	591	F	S	tTc/tCc	5.67	1	0	benign	0.17	neutral	0.42	neutral	0.58	neutral	-2.46	deleterious	-6.61	medium_impact	2.94	0.73	neutral	0.2	damaging	2.51	19.50	deleterious	0.27	0.45	0.58	disease	0.79	disease	0.67	disease	0.67	disease	3	0.5	neutral	0.63	deleterious	-3	neutral	0.40	neutral	-0.09	medium_impact	0.16	medium_impact	1.48	medium_impact	0.73	0.85	NA	NA	0.49	N	0.97	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14108	14108	T	G	MI.23026	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1772	591	F	C	tTc/tGc	5.67	1	0	benign	0.17	neutral	0.12	neutral	0.48	deleterious	-5.11	deleterious	-6.69	high_impact	3.74	0.67	neutral	0.19	damaging	2.37	18.63	deleterious	0.2	0.45	0.76	disease	0.85	disease	0.74	disease	0.79	disease	6	0.86	neutral	0.48	deleterious	-2	neutral	0.41	neutral	-0.09	medium_impact	-0.25	medium_impact	2.21	high_impact	0.59	0.8	NA	NA	0.5	N	0.99	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14109	14109	C	G	MI.23027	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1773	591	F	L	ttC/ttG	4.52	1	0	benign	0.17	neutral	1	neutral	0.61	neutral	-2.03	deleterious	-4.96	medium_impact	2.27	0.75	neutral	0.36	neutral	2.64	20.50	deleterious	0.42	0.55	0.36	neutral	0.75	disease	0.64	disease	0.58	disease	2	0.17	neutral	0.92	deleterious	-3	neutral	0.35	neutral	-0.09	medium_impact	1.89	high_impact	0.87	medium_impact	0.63	0.8	NA	NA	0.39	N	0.92	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14109	14109	C	A	MI.23028	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1773	591	F	L	ttC/ttA	4.52	1	0	benign	0.17	neutral	1	neutral	0.61	neutral	-2.03	deleterious	-4.96	medium_impact	2.27	0.75	neutral	0.36	neutral	2.93	22.00	deleterious	0.42	0.55	0.36	neutral	0.75	disease	0.64	disease	0.58	disease	2	0.17	neutral	0.92	deleterious	-3	neutral	0.35	neutral	-0.09	medium_impact	1.89	high_impact	0.87	medium_impact	0.63	0.8	NA	NA	0.39	N	0.92	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14110	14110	T	A	MI.23029	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1774	592	F	I	Ttc/Atc	-3.04	0	0.01	benign	0.17	neutral	0.99	neutral	1.11	neutral	1.05	neutral	1.13	neutral_impact	0.02	0.84	neutral	0.99	neutral	1.34	12.47	neutral	0.17	0.45	0.32	neutral	0.41	neutral	0.44	neutral	0.46	neutral	1	0.14	neutral	0.91	deleterious	-6	neutral	0.29	neutral	-0.09	medium_impact	1.33	medium_impact	-1.18	low_impact	0.71	0.85	17.91	17.58	0.25	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6103	6103	T	G	MI.2303	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	200	67	F	C	tTc/tGc	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.23	deleterious	-6.85	deleterious	-5.15	high_impact	5.12	0.67	neutral	0.15	damaging	3.98	23.60	deleterious	0.19	0.55	0.94	disease	0.86	disease	0.68	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.35	low_impact	-1.48	low_impact	3.63	high_impact	0.33	0.9	1.17	6.64	0.66	P	0.91	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14110	14110	T	C	MI.23030	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1774	592	F	L	Ttc/Ctc	-3.04	0	0.01	benign	0.17	neutral	1	neutral	1.2	neutral	1.58	neutral	2.62	neutral_impact	-0.53	0.89	neutral	0.99	neutral	-0.43	0.33	neutral	0.32	0.5	0.18	neutral	0.24	neutral	0.38	neutral	0.43	neutral	1	0.17	neutral	0.92	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	1.89	high_impact	-1.69	low_impact	0.68	0.85	17.91	17.58	0.33	N	0.00	polymorphism	1	0.00	rs371451099	.	.	.	.	.	COSM6716773	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14110	14110	T	G	MI.23031	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1774	592	F	V	Ttc/Gtc	-3.04	0	0.01	benign	0.17	neutral	0.58	neutral	1.11	neutral	1.03	neutral	0.39	low_impact	1.6	0.89	neutral	0.94	neutral	2.25	17.82	deleterious	0.23	0.45	0.33	neutral	0.58	disease	0.49	neutral	0.48	neutral	0	0.31	neutral	0.71	deleterious	-6	neutral	0.30	neutral	-0.09	medium_impact	0.31	medium_impact	0.26	medium_impact	0.75	0.85	17.91	17.58	0.27	N	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14111	14111	T	C	MI.23032	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1775	592	F	S	tTc/tCc	-4.87	0	0	benign	0.17	neutral	0.66	neutral	0.96	neutral	-0.62	neutral	-1.72	low_impact	1.09	0.77	neutral	0.82	neutral	2.53	19.63	deleterious	0.17	0.45	0.45	neutral	0.52	disease	0.63	disease	0.67	disease	3	0.22	neutral	0.75	deleterious	-6	neutral	0.32	neutral	-0.09	medium_impact	0.39	medium_impact	-0.21	medium_impact	0.62	0.8	17.91	17.58	0.2	N	0.39	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14111	14111	T	G	MI.23033	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1775	592	F	C	tTc/tGc	-4.87	0	0	benign	0.17	neutral	0.11	neutral	0.91	neutral	-2.56	neutral	-1.22	medium_impact	2.41	0.72	neutral	0.62	neutral	2.40	18.84	deleterious	0.19	0.45	0.73	disease	0.7	disease	0.65	disease	0.73	disease	5	0.87	neutral	0.47	deleterious	-3	neutral	0.36	neutral	-0.09	medium_impact	-0.27	medium_impact	1	medium_impact	0.52	0.8	17.91	17.58	0.32	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14111	14111	T	A	MI.23034	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1775	592	F	Y	tTc/tAc	-4.87	0	0	benign	0.17	neutral	0.63	neutral	0.92	neutral	-1.74	neutral	-0.95	medium_impact	2.41	0.81	neutral	0.8	neutral	2.54	19.72	deleterious	0.2	0.45	0.55	disease	0.47	neutral	0.63	disease	0.65	disease	3	0.25	neutral	0.73	deleterious	-3	neutral	0.35	neutral	-0.09	medium_impact	0.36	medium_impact	1	medium_impact	0.72	0.85	17.91	17.58	0.28	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14112	14112	C	A	MI.23035	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1776	592	F	L	ttC/ttA	2.92	0.73	0	benign	0.17	neutral	1	neutral	1.2	neutral	1.58	neutral	2.62	neutral_impact	-0.53	0.89	neutral	0.99	neutral	0.25	5.22	deleterious	0.32	0.5	0.18	neutral	0.24	neutral	0.38	neutral	0.43	neutral	1	0.17	neutral	0.92	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	1.89	high_impact	-1.69	low_impact	0.68	0.85	17.91	17.58	0.37	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14112	14112	C	G	MI.23036	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1776	592	F	L	ttC/ttG	2.92	0.73	0	benign	0.17	neutral	1	neutral	1.2	neutral	1.58	neutral	2.62	neutral_impact	-0.53	0.89	neutral	0.99	neutral	-0.05	2.14	deleterious	0.32	0.5	0.18	neutral	0.24	neutral	0.38	neutral	0.43	neutral	1	0.17	neutral	0.92	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	1.89	high_impact	-1.69	low_impact	0.68	0.85	17.91	17.58	0.36	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14113	14113	T	G	MI.23037	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1777	593	F	V	Ttc/Gtc	-6.94	0	0	benign	0.17	neutral	0.52	neutral	1.03	neutral	0.3	neutral	1.94	neutral_impact	0.55	0.85	neutral	0.99	neutral	0.96	10.45	neutral	0.28	0.45	0.26	neutral	0.48	neutral	0.38	neutral	0.46	neutral	1	0.38	neutral	0.68	deleterious	-6	neutral	0.29	neutral	-0.09	medium_impact	0.25	medium_impact	-0.7	medium_impact	0.60	0.8	6.63	9.63	0.27	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14113	14113	T	C	MI.23038	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1777	593	F	L	Ttc/Ctc	-6.94	0	0	benign	0.17	neutral	0.76	neutral	1.3	neutral	1.98	neutral	1.65	neutral_impact	-1.44	0.79	neutral	0.98	neutral	0.02	2.80	deleterious	0.44	0.55	0.18	neutral	0.18	neutral	0.3	neutral	0.24	neutral	5	0.13	neutral	0.8	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	0.51	medium_impact	-2.52	low_impact	0.73	0.85	6.63	9.63	0.27	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14113	14113	T	A	MI.23039	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1777	593	F	I	Ttc/Atc	-6.94	0	0	benign	0.17	neutral	0.54	neutral	1.08	neutral	0.75	neutral	2.36	neutral_impact	-1.86	0.83	neutral	0.99	neutral	-0.11	1.69	neutral	0.22	0.45	0.21	neutral	0.13	neutral	0.3	neutral	0.22	neutral	6	0.36	neutral	0.69	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	0.27	medium_impact	-2.9	low_impact	0.57	0.8	6.63	9.63	0.28	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6103	6103	T	C	MI.2304	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	200	67	F	S	tTc/tCc	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.24	deleterious	-5.29	deleterious	-5.15	high_impact	4.57	0.66	neutral	0.21	damaging	4.10	23.70	deleterious	0.19	0.55	0.91	disease	0.86	disease	0.65	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.12	high_impact	0.53	0.9	1.17	6.64	0.55	P	0.84	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14114	14114	T	G	MI.23040	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1778	593	F	C	tTc/tGc	-2.81	0	0	benign	0.17	neutral	0.17	neutral	0.93	neutral	-1.38	neutral	-0.76	low_impact	1	0.7	neutral	0.69	neutral	2.37	18.64	deleterious	0.2	0.45	0.42	neutral	0.64	disease	0.51	disease	0.57	disease	1	0.8	neutral	0.5	deleterious	-6	neutral	0.31	neutral	-0.09	medium_impact	-0.15	medium_impact	-0.29	medium_impact	0.51	0.8	6.63	9.63	0.39	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14114	14114	T	C	MI.23041	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1778	593	F	S	tTc/tCc	-2.81	0	0	benign	0.17	neutral	0.49	neutral	0.95	neutral	-0.77	neutral	-1.14	low_impact	0.8	0.72	neutral	0.81	neutral	2.56	19.88	deleterious	0.19	0.45	0.45	neutral	0.45	neutral	0.57	disease	0.52	disease	0	0.41	neutral	0.66	deleterious	-6	neutral	0.32	neutral	-0.09	medium_impact	0.22	medium_impact	-0.47	medium_impact	0.56	0.8	6.63	9.63	0.35	N	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14114	14114	T	A	MI.23042	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1778	593	F	Y	tTc/tAc	-2.81	0	0	benign	0.17	neutral	1	neutral	0.92	neutral	-1.83	neutral	-0.75	low_impact	1	0.75	neutral	0.85	neutral	2.58	19.95	deleterious	0.31	0.45	0.55	disease	0.43	neutral	0.56	disease	0.64	disease	3	0.17	neutral	0.92	deleterious	-6	neutral	0.34	neutral	-0.09	medium_impact	1.89	high_impact	-0.29	medium_impact	0.64	0.8	6.63	9.63	0.25	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14115	14115	C	G	MI.23043	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1779	593	F	L	ttC/ttG	1.08	0.13	0	benign	0.17	neutral	0.76	neutral	1.3	neutral	1.98	neutral	1.65	neutral_impact	-1.44	0.79	neutral	0.98	neutral	0.43	6.90	deleterious	0.44	0.55	0.18	neutral	0.18	neutral	0.3	neutral	0.24	neutral	5	0.13	neutral	0.8	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	0.51	medium_impact	-2.52	low_impact	0.73	0.85	6.63	9.63	0.33	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14115	14115	C	A	MI.23044	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1779	593	F	L	ttC/ttA	1.08	0.13	0	benign	0.17	neutral	0.76	neutral	1.3	neutral	1.98	neutral	1.65	neutral_impact	-1.44	0.79	neutral	0.98	neutral	0.71	8.91	deleterious	0.44	0.55	0.18	neutral	0.18	neutral	0.3	neutral	0.24	neutral	5	0.13	neutral	0.8	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	0.51	medium_impact	-2.52	low_impact	0.73	0.85	6.63	9.63	0.33	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14116	14116	C	A	MI.23045	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1780	594	P	T	Cca/Aca	-6.25	0	0	benign	0.17	neutral	0.66	neutral	1.18	neutral	3.14	neutral	2.22	neutral_impact	-1.53	0.8	neutral	0.98	neutral	-0.77	0.05	neutral	0.35	0.5	0.17	neutral	0.03	neutral	0.25	neutral	0.21	neutral	6	0.22	neutral	0.75	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	0.39	medium_impact	-2.6	low_impact	0.72	0.85	25.54	22.05	0.33	N	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14116	14116	C	G	MI.23046	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1780	594	P	A	Cca/Gca	-6.25	0	0	benign	0.17	neutral	0.61	neutral	1.08	neutral	2.1	neutral	0.91	neutral_impact	0.42	0.79	neutral	0.88	neutral	1.32	12.39	neutral	0.3	0.45	0.27	neutral	0.11	neutral	0.52	disease	0.31	neutral	4	0.28	neutral	0.72	deleterious	-6	neutral	0.29	neutral	-0.09	medium_impact	0.34	medium_impact	-0.82	medium_impact	0.64	0.8	25.54	22.05	0.35	N	0.36	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14116	14116	C	T	MI.23047	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1780	594	P	S	Cca/Tca	-6.25	0	0	benign	0.17	neutral	0.4	neutral	1.17	neutral	3.06	neutral	2.79	neutral_impact	-1.38	0.83	neutral	0.98	neutral	0.32	5.85	deleterious	0.4	0.5	0.26	neutral	0.06	neutral	0.28	neutral	0.24	neutral	5	0.52	neutral	0.62	deleterious	-6	neutral	0.27	neutral	-0.09	medium_impact	0.14	medium_impact	-2.46	low_impact	0.46	0.8	25.54	22.05	0.37	N	0.21	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14117	14117	C	G	MI.23048	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1781	594	P	R	cCa/cGa	0.17	0	0	benign	0.17	neutral	0.32	neutral	1	neutral	0.26	neutral	-0.42	low_impact	1.39	0.74	neutral	0.63	neutral	1.85	15.31	deleterious	0.28	0.45	0.35	neutral	0.61	disease	0.66	disease	0.74	disease	5	0.62	neutral	0.58	deleterious	-6	neutral	0.33	neutral	-0.09	medium_impact	0.05	medium_impact	0.07	medium_impact	0.70	0.85	25.54	22.05	0.37	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14117	14117	C	A	MI.23049	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1781	594	P	Q	cCa/cAa	0.17	0	0	benign	0.17	neutral	0.27	neutral	1	neutral	0.18	neutral	0.14	low_impact	1.39	0.79	neutral	0.7	neutral	2.34	18.43	deleterious	0.2	0.45	0.33	neutral	0.27	neutral	0.55	disease	0.47	neutral	1	0.68	neutral	0.55	deleterious	-6	neutral	0.29	neutral	-0.09	medium_impact	-0.01	medium_impact	0.07	medium_impact	0.52	0.8	25.54	22.05	0.41	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6103	6103	T	A	MI.2305	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	200	67	F	Y	tTc/tAc	7.53	1	0	possibly_damaging	0.66	deleterious	0	neutral	2.33	deleterious	-3.16	neutral	-1.93	high_impact	4.78	0.68	neutral	0.15	damaging	4.11	23.70	deleterious	0.19	0.55	0.81	disease	0.81	disease	0.61	disease	0.72	disease	4	1	deleterious	0.17	neutral	5	deleterious	0.67	deleterious	-1.03	low_impact	-1.48	low_impact	3.32	high_impact	0.63	0.9	1.17	6.64	0.72	P	0.59	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14117	14117	C	T	MI.23050	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1781	594	P	L	cCa/cTa	0.17	0	0	benign	0.17	neutral	0.69	neutral	1.16	neutral	2.98	neutral	-0.69	neutral_impact	0.24	0.77	neutral	0.77	neutral	2.66	20.60	deleterious	0.32	0.5	0.32	neutral	0.38	neutral	0.52	disease	0.49	neutral	0	0.19	neutral	0.76	deleterious	-6	neutral	0.30	neutral	-0.09	medium_impact	0.42	medium_impact	-0.98	medium_impact	0.83	0.85	25.54	22.05	0.3	N	0.74	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14119	14119	C	A	MI.23051	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1783	595	L	I	Ctc/Atc	-6.94	0	0	possibly_damaging	0.54	neutral	0.44	neutral	0.94	neutral	-0.35	neutral	-0.34	neutral_impact	0.3	0.8	neutral	0.97	neutral	1.37	12.62	neutral	0.34	0.5	0.21	neutral	0.06	neutral	0.28	neutral	0.26	neutral	5	0.57	neutral	0.45	neutral	-3	neutral	0.41	neutral	-0.81	medium_impact	0.18	medium_impact	-0.93	medium_impact	0.65	0.8	21.89	13.98	0.42	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14119	14119	C	G	MI.23052	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1783	595	L	V	Ctc/Gtc	-6.94	0	0	possibly_damaging	0.54	neutral	0.27	neutral	0.89	neutral	-0.64	neutral	-0.81	low_impact	1.74	0.81	neutral	0.52	neutral	1.93	15.76	deleterious	0.36	0.5	0.23	neutral	0.25	neutral	0.38	neutral	0.44	neutral	1	0.72	neutral	0.37	neutral	-3	neutral	0.42	neutral	-0.81	medium_impact	-0.01	medium_impact	0.39	medium_impact	0.62	0.8	21.89	13.98	0.39	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14119	14119	C	T	MI.23053	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1783	595	L	F	Ctc/Ttc	-6.94	0	0	possibly_damaging	0.54	neutral	0.32	neutral	0.73	neutral	-2.72	neutral	-1.83	low_impact	1.9	0.77	neutral	0.44	neutral	2.44	19.10	deleterious	0.35	0.5	0.35	neutral	0.39	neutral	0.43	neutral	0.47	neutral	1	0.67	neutral	0.39	neutral	-3	neutral	0.45	deleterious	-0.81	medium_impact	0.05	medium_impact	0.53	medium_impact	0.59	0.8	21.89	13.98	0.38	N	0.28	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14120	14120	T	C	MI.23054	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1784	595	L	P	cTc/cCc	-6.25	0	0	possibly_damaging	0.54	neutral	0.11	neutral	0.69	deleterious	-4.46	deleterious	-3.47	low_impact	1.47	0.64	neutral	0.44	neutral	2.45	19.12	deleterious	0.16	0.45	0.77	disease	0.75	disease	0.73	disease	0.76	disease	5	0.88	neutral	0.29	neutral	-3	neutral	0.59	deleterious	-0.81	medium_impact	-0.27	medium_impact	0.14	medium_impact	0.63	0.8	21.89	13.98	0.27	N	0.90	polymorphism	1	0.34	.	.	.	.	.	.	COSM488757	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14120	14120	T	G	MI.23055	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1784	595	L	R	cTc/cGc	-6.25	0	0	possibly_damaging	0.54	neutral	0.15	neutral	0.7	deleterious	-3.87	deleterious	-3.34	medium_impact	2.71	0.66	neutral	0.18	damaging	3.83	23.40	deleterious	0.15	0.45	0.7	disease	0.8	disease	0.73	disease	0.79	disease	6	0.84	neutral	0.31	neutral	0	NA	0.58	deleterious	-0.81	medium_impact	-0.18	medium_impact	1.27	medium_impact	0.68	0.85	21.89	13.98	0.24	N	0.88	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14120	14120	T	A	MI.23056	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1784	595	L	H	cTc/cAc	-6.25	0	0	possibly_damaging	0.54	neutral	0.23	neutral	0.69	deleterious	-4.41	deleterious	-3.75	medium_impact	2.71	0.73	neutral	0.25	damaging	2.89	21.80	deleterious	0.21	0.45	0.77	disease	0.6	disease	0.7	disease	0.74	disease	5	0.76	neutral	0.35	neutral	0	NA	0.54	deleterious	-0.81	medium_impact	-0.06	medium_impact	1.27	medium_impact	0.66	0.8	21.89	13.98	0.28	N	0.80	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14122	14122	A	T	MI.23057	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1786	596	I	F	Atc/Ttc	-8.77	0	0.01	benign	0.17	neutral	0.62	neutral	0.86	neutral	-1.18	neutral	-1.6	low_impact	1.31	0.79	neutral	0.8	neutral	0.42	6.82	deleterious	0.33	0.5	0.42	neutral	0.38	neutral	0.37	neutral	0.44	neutral	1	0.26	neutral	0.73	deleterious	-6	neutral	0.32	neutral	-0.09	medium_impact	0.35	medium_impact	-0.01	medium_impact	0.60	0.8	5.97	9.95	0.29	N	0.39	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14122	14122	A	C	MI.23058	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1786	596	I	L	Atc/Ctc	-8.77	0	0.01	benign	0.17	neutral	1	neutral	1.1	neutral	0.5	neutral	0.04	neutral_impact	-0.48	0.82	neutral	0.98	neutral	-0.16	1.32	neutral	0.29	0.45	0.23	neutral	0.12	neutral	0.27	neutral	0.24	neutral	5	0.17	neutral	0.92	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	1.89	high_impact	-1.64	low_impact	0.46	0.8	5.97	9.95	0.32	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14122	14122	A	G	MI.23059	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1786	596	I	V	Atc/Gtc	-8.77	0	0.01	benign	0.17	neutral	0.48	neutral	0.91	neutral	-0.64	neutral	0.1	low_impact	1.07	0.86	neutral	0.96	neutral	-0.41	0.37	neutral	0.46	0.55	0.3	neutral	0.1	neutral	0.35	neutral	0.31	neutral	4	0.43	neutral	0.66	deleterious	-6	neutral	0.27	neutral	-0.09	medium_impact	0.21	medium_impact	-0.23	medium_impact	0.55	0.8	5.97	9.95	0.4	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6104	6104	C	A	MI.2306	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	201	67	F	L	ttC/ttA	5.91	1	0	benign	0.13	deleterious	0	neutral	2.42	neutral	-2.22	deleterious	-3.86	medium_impact	3.04	0.66	neutral	0.15	damaging	4.55	24.40	deleterious	0.33	0.55	0.33	neutral	0.78	disease	0.59	disease	0.65	disease	3	1	deleterious	0.44	neutral	1	deleterious	0.25	neutral	0.02	medium_impact	-1.48	low_impact	1.71	medium_impact	0.56	0.9	1.17	6.64	0.5	N	0.83	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14123	14123	T	C	MI.23060	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1787	596	I	T	aTc/aCc	-3.27	0	0	benign	0.17	neutral	0.53	neutral	0.85	neutral	-1.25	neutral	0.94	neutral_impact	0.32	0.9	neutral	0.99	neutral	-0.99	0.02	neutral	0.34	0.5	0.43	neutral	0.07	neutral	0.35	neutral	0.3	neutral	4	0.37	neutral	0.68	deleterious	-6	neutral	0.29	neutral	-0.09	medium_impact	0.26	medium_impact	-0.91	medium_impact	0.57	0.8	5.97	9.95	0.39	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14123	14123	T	G	MI.23061	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1787	596	I	S	aTc/aGc	-3.27	0	0	benign	0.17	neutral	0.61	neutral	0.79	neutral	-2.54	neutral	-0.69	low_impact	1.31	0.87	neutral	0.9	neutral	0.88	9.95	deleterious	0.26	0.45	0.48	neutral	0.35	neutral	0.43	neutral	0.41	neutral	2	0.28	neutral	0.72	deleterious	-6	neutral	0.32	neutral	-0.09	medium_impact	0.34	medium_impact	-0.01	medium_impact	0.62	0.8	5.97	9.95	0.31	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14123	14123	T	A	MI.23062	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1787	596	I	N	aTc/aAc	-3.27	0	0	benign	0.17	neutral	0.29	neutral	0.76	deleterious	-3.78	neutral	-1.79	medium_impact	2.36	0.74	neutral	0.58	neutral	1.49	13.26	neutral	0.22	0.45	0.7	disease	0.54	disease	0.52	disease	0.6	disease	2	0.66	neutral	0.56	deleterious	-3	neutral	0.39	neutral	-0.09	medium_impact	0.02	medium_impact	0.95	medium_impact	0.67	0.85	5.97	9.95	0.34	N	0.50	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14124	14124	C	G	MI.23063	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1788	596	I	M	atC/atG	-3.04	0	0	benign	0.17	neutral	0.24	neutral	0.81	neutral	-2.01	neutral	-0.15	neutral_impact	0.73	0.82	neutral	0.98	neutral	0.23	4.96	deleterious	0.39	0.5	0.38	neutral	0.13	neutral	0.34	neutral	0.32	neutral	4	0.72	neutral	0.54	deleterious	-6	neutral	0.28	neutral	-0.09	medium_impact	-0.04	medium_impact	-0.54	medium_impact	0.68	0.85	5.97	9.95	0.45	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14124	14124	C	A	MI.23064	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1788	596	I	M	atC/atA	-3.04	0	0	benign	0.17	neutral	0.24	neutral	0.81	neutral	-2.01	neutral	-0.15	neutral_impact	0.73	0.82	neutral	0.98	neutral	0.70	8.85	deleterious	0.39	0.5	0.38	neutral	0.13	neutral	0.34	neutral	0.32	neutral	4	0.72	neutral	0.54	deleterious	-6	neutral	0.28	neutral	-0.09	medium_impact	-0.04	medium_impact	-0.54	medium_impact	0.68	0.85	5.97	9.95	0.45	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14125	14125	C	A	MI.23065	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1789	597	L	M	Cta/Ata	-9.69	0	0	possibly_damaging	0.54	neutral	0.24	neutral	0.72	neutral	-2.93	neutral	-0.94	low_impact	1.12	0.84	neutral	0.92	neutral	2.17	17.34	deleterious	0.29	0.45	0.53	disease	0.12	neutral	0.37	neutral	0.26	neutral	5	0.75	neutral	0.35	neutral	-3	neutral	0.43	neutral	-0.81	medium_impact	-0.04	medium_impact	-0.18	medium_impact	0.71	0.85	9.78	14.92	0.47	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14125	14125	C	G	MI.23066	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1789	597	L	V	Cta/Gta	-9.69	0	0	possibly_damaging	0.54	neutral	0.37	neutral	0.84	neutral	-1.36	neutral	-1.17	medium_impact	2.12	0.87	neutral	0.97	neutral	2.03	16.37	deleterious	0.3	0.45	0.28	neutral	0.21	neutral	0.41	neutral	0.39	neutral	2	0.62	neutral	0.42	neutral	0	NA	0.43	neutral	-0.81	medium_impact	0.11	medium_impact	0.73	medium_impact	0.54	0.8	9.78	14.92	0.42	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14126	14126	T	C	MI.23067	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1790	597	L	P	cTa/cCa	-5.56	0	0	possibly_damaging	0.54	neutral	0.12	neutral	0.66	deleterious	-5.19	deleterious	-4.2	medium_impact	3.23	0.55	damaging	0.44	neutral	3.64	23.20	deleterious	0.21	0.45	0.7	disease	0.7	disease	0.73	disease	0.75	disease	5	0.87	neutral	0.29	neutral	0	NA	0.58	deleterious	-0.81	medium_impact	-0.25	medium_impact	1.75	medium_impact	0.50	0.8	9.78	14.92	0.34	N	0.94	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14126	14126	T	A	MI.23068	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1790	597	L	Q	cTa/cAa	-5.56	0	0	possibly_damaging	0.54	neutral	0.23	neutral	0.67	deleterious	-4.45	deleterious	-3.78	medium_impact	3.23	0.72	neutral	0.61	neutral	3.81	23.40	deleterious	0.2	0.45	0.58	disease	0.52	disease	0.61	disease	0.69	disease	4	0.76	neutral	0.35	neutral	0	NA	0.48	deleterious	-0.81	medium_impact	-0.06	medium_impact	1.75	medium_impact	0.66	0.8	9.78	14.92	0.37	N	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14126	14126	T	G	MI.23069	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1790	597	L	R	cTa/cGa	-5.56	0	0	possibly_damaging	0.54	neutral	0.25	neutral	0.67	deleterious	-4.43	deleterious	-4.03	medium_impact	3.23	0.63	neutral	0.47	neutral	3.88	23.50	deleterious	0.2	0.45	0.45	neutral	0.76	disease	0.73	disease	0.75	disease	5	0.74	neutral	0.36	neutral	0	NA	0.54	deleterious	-0.81	medium_impact	-0.03	medium_impact	1.75	medium_impact	0.58	0.8	9.78	14.92	0.36	N	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6104	6104	C	G	MI.2307	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	201	67	F	L	ttC/ttG	5.91	1	0	benign	0.13	deleterious	0	neutral	2.42	neutral	-2.22	deleterious	-3.86	medium_impact	3.04	0.66	neutral	0.15	damaging	4.25	23.90	deleterious	0.33	0.55	0.33	neutral	0.78	disease	0.59	disease	0.65	disease	3	1	deleterious	0.44	neutral	1	deleterious	0.25	neutral	0.02	medium_impact	-1.48	low_impact	1.71	medium_impact	0.56	0.9	1.17	6.64	0.5	N	0.83	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14128	14128	A	G	MI.23070	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1792	598	T	A	Acc/Gcc	-1.67	0	0	possibly_damaging	0.54	neutral	0.51	neutral	1.07	neutral	0.91	neutral	0.66	neutral_impact	0.34	0.86	neutral	0.99	neutral	0.50	7.46	deleterious	0.56	0.6	0.25	neutral	0.04	neutral	0.27	neutral	0.18	neutral	6	0.52	neutral	0.49	deleterious	-3	neutral	0.35	neutral	-0.81	medium_impact	0.24	medium_impact	-0.89	medium_impact	0.53	0.8	26.2	22.65	0.4	N	0.04	polymorphism	1	0.00	rs386829201	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14128	14128	A	C	MI.23071	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1792	598	T	P	Acc/Ccc	-1.67	0	0	possibly_damaging	0.54	neutral	0.15	neutral	0.95	neutral	-1.44	neutral	-1.45	medium_impact	2.14	0.68	neutral	0.52	neutral	2.12	16.99	deleterious	0.19	0.45	0.49	neutral	0.59	disease	0.58	disease	0.72	disease	4	0.84	neutral	0.31	neutral	0	NA	0.46	deleterious	-0.81	medium_impact	-0.18	medium_impact	0.75	medium_impact	0.70	0.85	26.2	22.65	0.35	N	0.38	polymorphism	1	0.04	rs386829201	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14128	14128	A	T	MI.23072	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1792	598	T	S	Acc/Tcc	-1.67	0	0	possibly_damaging	0.54	neutral	0.48	neutral	0.99	neutral	-0.14	neutral	0.45	low_impact	0.82	0.83	neutral	0.99	neutral	1.06	11.01	neutral	0.4	0.5	0.15	neutral	0.07	neutral	0.3	neutral	0.27	neutral	5	0.54	neutral	0.47	deleterious	-3	neutral	0.34	neutral	-0.81	medium_impact	0.21	medium_impact	-0.45	medium_impact	0.68	0.85	26.2	22.65	0.41	N	0.03	polymorphism	1	0.01	rs386829201	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14129	14129	C	A	MI.23073	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1793	598	T	N	aCc/aAc	-0.75	0	0	possibly_damaging	0.54	neutral	0.25	neutral	0.94	neutral	-1.97	neutral	-1.32	medium_impact	2.14	0.8	neutral	0.61	neutral	3.70	23.30	deleterious	0.47	0.55	0.26	neutral	0.34	neutral	0.43	neutral	0.46	neutral	1	0.74	neutral	0.36	neutral	0	NA	0.38	neutral	-0.81	medium_impact	-0.03	medium_impact	0.75	medium_impact	0.70	0.85	26.2	22.65	0.39	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14129	14129	C	G	MI.23074	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1793	598	T	S	aCc/aGc	-0.75	0	0	possibly_damaging	0.54	neutral	0.48	neutral	0.99	neutral	-0.14	neutral	0.45	low_impact	0.82	0.83	neutral	0.99	neutral	1.50	13.32	neutral	0.4	0.5	0.15	neutral	0.07	neutral	0.3	neutral	0.27	neutral	5	0.54	neutral	0.47	deleterious	-3	neutral	0.34	neutral	-0.81	medium_impact	0.21	medium_impact	-0.45	medium_impact	0.68	0.85	26.2	22.65	0.44	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14129	14129	C	T	MI.23075	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1793	598	T	I	aCc/aTc	-0.75	0	0	possibly_damaging	0.54	neutral	0.53	neutral	1.15	neutral	1.58	neutral	-1.38	neutral_impact	0.34	0.84	neutral	0.97	neutral	2.30	18.17	deleterious	0.33	0.5	0.46	neutral	0.14	neutral	0.33	neutral	0.3	neutral	4	0.51	neutral	0.5	deleterious	-3	neutral	0.37	neutral	-0.81	medium_impact	0.26	medium_impact	-0.89	medium_impact	0.66	0.8	26.2	22.65	0.3	N	0.04	polymorphism	1	0.03	rs879039557	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14131	14131	C	G	MI.23076	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1795	599	L	V	Cta/Gta	-7.4	0	0	possibly_damaging	0.54	neutral	0.59	neutral	0.81	neutral	-1.26	neutral	-1.1	low_impact	1.7	0.83	neutral	0.87	neutral	1.73	14.56	neutral	0.35	0.5	0.22	neutral	0.1	neutral	0.34	neutral	0.32	neutral	4	0.48	neutral	0.53	deleterious	-3	neutral	0.41	neutral	-0.81	medium_impact	0.32	medium_impact	0.35	medium_impact	0.64	0.8	17.74	14.51	0.36	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14131	14131	C	A	MI.23077	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1795	599	L	M	Cta/Ata	-7.4	0	0	possibly_damaging	0.54	neutral	0.37	neutral	0.77	neutral	-2.6	neutral	-0.71	low_impact	1.04	0.81	neutral	1	neutral	1.92	15.69	deleterious	0.21	0.45	0.28	neutral	0.05	neutral	0.27	neutral	0.24	neutral	5	0.62	neutral	0.42	neutral	-3	neutral	0.40	neutral	-0.81	medium_impact	0.11	medium_impact	-0.25	medium_impact	0.52	0.8	17.74	14.51	0.48	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14132	14132	T	C	MI.23078	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1796	599	L	P	cTa/cCa	-8.54	0	0	possibly_damaging	0.54	neutral	0.13	neutral	0.68	deleterious	-4.76	deleterious	-3.41	medium_impact	1.98	0.76	neutral	0.78	neutral	2.70	20.80	deleterious	0.2	0.45	0.67	disease	0.56	disease	0.7	disease	0.69	disease	4	0.86	neutral	0.3	neutral	0	NA	0.56	deleterious	-0.81	medium_impact	-0.22	medium_impact	0.61	medium_impact	0.51	0.8	17.74	14.51	0.33	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14132	14132	T	A	MI.23079	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1796	599	L	Q	cTa/cAa	-8.54	0	0	possibly_damaging	0.54	neutral	0.28	neutral	0.68	deleterious	-4.12	deleterious	-3.21	medium_impact	2.67	0.75	neutral	0.65	neutral	3.97	23.60	deleterious	0.21	0.45	0.61	disease	0.36	neutral	0.57	disease	0.64	disease	3	0.71	neutral	0.37	neutral	0	NA	0.48	deleterious	-0.81	medium_impact	0.01	medium_impact	1.24	medium_impact	0.61	0.8	17.74	14.51	0.37	N	0.85	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6105	6105	T	C	MI.2308	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	202	68	F	L	Ttc/Ctc	0.59	0.99	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-2.72	deleterious	-3.87	medium_impact	3.06	0.57	damaging	0.18	damaging	3.87	23.50	deleterious	0.34	0.55	0.26	neutral	0.81	disease	0.59	disease	0.69	disease	4	1	deleterious	0	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	1.73	medium_impact	0.68	0.9	3.9	6.74	0.4	N	0.83	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14132	14132	T	G	MI.23080	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1796	599	L	R	cTa/cGa	-8.54	0	0	possibly_damaging	0.54	neutral	0.22	neutral	0.69	deleterious	-4.11	deleterious	-3.37	medium_impact	2.67	0.66	neutral	0.54	neutral	4.13	23.80	deleterious	0.22	0.45	0.58	disease	0.61	disease	0.69	disease	0.74	disease	5	0.77	neutral	0.34	neutral	0	NA	0.55	deleterious	-0.81	medium_impact	-0.07	medium_impact	1.24	medium_impact	0.57	0.8	17.74	14.51	0.33	N	0.87	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14134	14134	C	G	MI.23081	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1798	600	L	V	Ctc/Gtc	-3.96	0	0	possibly_damaging	0.54	neutral	0.19	neutral	0.81	neutral	-1.18	neutral	-1.11	low_impact	1.25	0.91	neutral	0.96	neutral	2.25	17.86	deleterious	0.35	0.5	0.27	neutral	0.12	neutral	0.4	neutral	0.3	neutral	4	0.8	neutral	0.33	neutral	-3	neutral	0.42	neutral	-0.81	medium_impact	-0.12	medium_impact	-0.06	medium_impact	0.57	0.8	12.77	11.85	0.51	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14134	14134	C	T	MI.23082	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1798	600	L	F	Ctc/Ttc	-3.96	0	0	possibly_damaging	0.54	neutral	0.46	neutral	0.71	neutral	-2.99	neutral	-1.66	low_impact	1.16	0.86	neutral	0.97	neutral	2.77	21.20	deleterious	0.29	0.45	0.22	neutral	0.17	neutral	0.4	neutral	0.31	neutral	4	0.55	neutral	0.46	neutral	-3	neutral	0.42	neutral	-0.81	medium_impact	0.19	medium_impact	-0.14	medium_impact	0.57	0.8	12.77	11.85	0.36	N	0.14	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14134	14134	C	A	MI.23083	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1798	600	L	I	Ctc/Atc	-3.96	0	0	possibly_damaging	0.54	neutral	0.53	neutral	0.83	neutral	-0.71	neutral	-0.56	low_impact	0.95	0.84	neutral	0.98	neutral	2.21	17.60	deleterious	0.34	0.5	0.27	neutral	0.06	neutral	0.3	neutral	0.24	neutral	5	0.51	neutral	0.5	deleterious	-3	neutral	0.41	neutral	-0.81	medium_impact	0.26	medium_impact	-0.34	medium_impact	0.57	0.8	12.77	11.85	0.38	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14135	14135	T	G	MI.23084	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1799	600	L	R	cTc/cGc	-5.33	0	0	possibly_damaging	0.54	neutral	0.09	neutral	0.65	deleterious	-4.19	deleterious	-3.56	medium_impact	2.4	0.65	neutral	0.51	neutral	4.08	23.70	deleterious	0.21	0.45	0.53	disease	0.62	disease	0.72	disease	0.75	disease	5	0.9	neutral	0.28	neutral	0	NA	0.54	deleterious	-0.81	medium_impact	-0.32	medium_impact	0.99	medium_impact	0.54	0.8	12.77	11.85	0.33	N	0.81	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14135	14135	T	C	MI.23085	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1799	600	L	P	cTc/cCc	-5.33	0	0	possibly_damaging	0.54	neutral	0.08	neutral	0.65	deleterious	-5.03	deleterious	-3.89	medium_impact	2.4	0.56	damaging	0.47	neutral	3.87	23.50	deleterious	0.21	0.45	0.64	disease	0.56	disease	0.72	disease	0.74	disease	5	0.91	neutral	0.27	neutral	0	NA	0.55	deleterious	-0.81	medium_impact	-0.35	medium_impact	0.99	medium_impact	0.64	0.8	12.77	11.85	0.33	N	0.88	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14135	14135	T	A	MI.23086	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1799	600	L	H	cTc/cAc	-5.33	0	0	possibly_damaging	0.54	neutral	0.14	neutral	0.64	deleterious	-5.12	deleterious	-3.93	medium_impact	2.4	0.73	neutral	0.58	neutral	4.21	23.90	deleterious	0.19	0.45	0.63	disease	0.42	neutral	0.69	disease	0.66	disease	3	0.85	neutral	0.3	neutral	0	NA	0.51	deleterious	-0.81	medium_impact	-0.2	medium_impact	0.99	medium_impact	0.46	0.8	12.77	11.85	0.36	N	0.75	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14137	14137	C	A	MI.23087	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1801	601	L	M	Cta/Ata	-9.69	0	0	possibly_damaging	0.54	neutral	0.2	neutral	0.8	neutral	-2.71	neutral	-0.47	low_impact	0.8	0.85	neutral	0.94	neutral	2.09	16.82	deleterious	0.23	0.45	0.44	neutral	0.06	neutral	0.29	neutral	0.23	neutral	5	0.79	neutral	0.33	neutral	-3	neutral	0.42	neutral	-0.81	medium_impact	-0.1	medium_impact	-0.47	medium_impact	0.65	0.8	NA	NA	0.51	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14137	14137	C	G	MI.23088	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1801	601	L	V	Cta/Gta	-9.69	0	0	possibly_damaging	0.54	neutral	0.24	neutral	0.81	neutral	-1.35	neutral	-0.96	low_impact	0.8	0.87	neutral	0.95	neutral	2.15	17.20	deleterious	0.28	0.45	0.27	neutral	0.09	neutral	0.35	neutral	0.27	neutral	5	0.75	neutral	0.35	neutral	-3	neutral	0.42	neutral	-0.81	medium_impact	-0.04	medium_impact	-0.47	medium_impact	0.39	0.8	NA	NA	0.51	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14138	14138	T	A	MI.23089	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1802	601	L	Q	cTa/cAa	-8.54	0	0	possibly_damaging	0.54	neutral	0.14	neutral	0.68	deleterious	-4.26	deleterious	-3.46	low_impact	0.8	0.71	neutral	0.26	damaging	3.95	23.60	deleterious	0.21	0.45	0.4	neutral	0.33	neutral	0.55	disease	0.49	neutral	0	0.85	neutral	0.3	neutral	-3	neutral	0.46	deleterious	-0.81	medium_impact	-0.2	medium_impact	-0.47	medium_impact	0.56	0.8	NA	NA	0.3	N	0.72	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6105	6105	T	G	MI.2309	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	202	68	F	V	Ttc/Gtc	0.59	0.99	0	probably_damaging	1	deleterious	0	neutral	2.81	deleterious	-3.64	deleterious	-4.51	high_impact	4.41	0.64	neutral	0.15	damaging	3.89	23.50	deleterious	0.21	0.55	0.64	disease	0.92	disease	0.69	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.61	0.9	3.9	6.74	0.5	N	0.84	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14138	14138	T	G	MI.23090	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1802	601	L	R	cTa/cGa	-8.54	0	0	possibly_damaging	0.54	neutral	0.12	neutral	0.68	deleterious	-4.2	deleterious	-3.74	low_impact	0.8	0.65	neutral	0.18	damaging	4.02	23.60	deleterious	0.21	0.45	0.31	neutral	0.55	disease	0.66	disease	0.69	disease	4	0.87	neutral	0.29	neutral	-3	neutral	0.50	deleterious	-0.81	medium_impact	-0.25	medium_impact	-0.47	medium_impact	0.52	0.8	NA	NA	0.27	N	0.81	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14138	14138	T	C	MI.23091	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1802	601	L	P	cTa/cCa	-8.54	0	0	possibly_damaging	0.54	neutral	0.05	neutral	0.68	deleterious	-5.13	deleterious	-3.97	low_impact	0.8	0.57	damaging	0.17	damaging	3.77	23.40	deleterious	0.18	0.45	0.43	neutral	0.49	neutral	0.67	disease	0.68	disease	4	0.95	neutral	0.26	neutral	-3	neutral	0.52	deleterious	-0.81	medium_impact	-0.47	medium_impact	-0.47	medium_impact	0.46	0.8	NA	NA	0.28	N	0.88	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14140	14140	A	G	MI.23092	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1804	602	I	V	Atc/Gtc	-1.21	0	0	benign	0.17	neutral	0.53	neutral	0.93	neutral	-0.6	neutral	-0.29	neutral_impact	0	0.91	neutral	0.92	neutral	-0.17	1.26	neutral	0.53	0.6	0.23	neutral	0.02	neutral	0.39	neutral	0.18	neutral	6	0.37	neutral	0.68	deleterious	-6	neutral	0.24	neutral	-0.09	medium_impact	0.26	medium_impact	-1.2	low_impact	0.31	0.8	NA	NA	0.42	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14140	14140	A	C	MI.23093	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1804	602	I	L	Atc/Ctc	-1.21	0	0	benign	0.17	neutral	0.72	neutral	0.98	neutral	-0.16	neutral	-0.07	neutral_impact	0	0.87	neutral	0.99	neutral	-0.48	0.25	neutral	0.38	0.5	0.21	neutral	0.03	neutral	0.29	neutral	0.14	neutral	7	0.16	neutral	0.78	deleterious	-6	neutral	0.25	neutral	-0.09	medium_impact	0.46	medium_impact	-1.2	low_impact	0.59	0.8	NA	NA	0.43	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14140	14140	A	T	MI.23094	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1804	602	I	F	Atc/Ttc	-1.21	0	0	benign	0.17	neutral	0.75	neutral	0.89	neutral	-1.03	neutral	-1.2	neutral_impact	0	0.89	neutral	0.91	neutral	1.10	11.20	neutral	0.46	0.55	0.19	neutral	0.15	neutral	0.46	neutral	0.23	neutral	5	0.14	neutral	0.79	deleterious	-6	neutral	0.26	neutral	-0.09	medium_impact	0.5	medium_impact	-1.2	low_impact	0.55	0.8	NA	NA	0.34	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14141	14141	T	A	MI.23095	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1805	602	I	N	aTc/aAc	-8.08	0	0	benign	0.17	neutral	0.31	neutral	0.82	neutral	-2.41	deleterious	-3.01	neutral_impact	0	0.7	neutral	0.61	neutral	2.95	22.10	deleterious	0.36	0.5	0.51	disease	0.27	neutral	0.62	disease	0.38	neutral	2	0.63	neutral	0.57	deleterious	-6	neutral	0.34	neutral	-0.09	medium_impact	0.04	medium_impact	-1.2	low_impact	0.52	0.8	NA	NA	0.35	N	0.39	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14141	14141	T	C	MI.23096	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1805	602	I	T	aTc/aCc	-8.08	0	0	benign	0.17	neutral	0.55	neutral	0.91	neutral	-0.75	neutral	-1.23	neutral_impact	0	0.89	neutral	0.86	neutral	0.73	9.01	deleterious	0.44	0.55	0.32	neutral	0.09	neutral	0.44	neutral	0.2	neutral	6	0.34	neutral	0.69	deleterious	-6	neutral	0.27	neutral	-0.09	medium_impact	0.28	medium_impact	-1.2	low_impact	0.33	0.8	NA	NA	0.36	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14141	14141	T	G	MI.23097	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1805	602	I	S	aTc/aGc	-8.08	0	0	benign	0.17	neutral	0.43	neutral	0.86	neutral	-1.56	neutral	-2.15	neutral_impact	0	0.85	neutral	0.83	neutral	1.57	13.69	neutral	0.36	0.5	0.35	neutral	0.23	neutral	0.52	disease	0.41	neutral	2	0.49	neutral	0.63	deleterious	-6	neutral	0.30	neutral	-0.09	medium_impact	0.17	medium_impact	-1.2	low_impact	0.47	0.8	NA	NA	0.32	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14142	14142	C	G	MI.23098	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1806	602	I	M	atC/atG	-0.98	0	0	benign	0.17	neutral	0.25	neutral	0.91	neutral	-0.74	neutral	-0.38	neutral_impact	0	0.88	neutral	0.91	neutral	-0.01	2.47	deleterious	0.55	0.6	0.38	neutral	0.05	neutral	0.39	neutral	0.18	neutral	6	0.71	neutral	0.54	deleterious	-6	neutral	0.28	neutral	-0.09	medium_impact	-0.03	medium_impact	-1.2	low_impact	0.61	0.8	NA	NA	0.5	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14142	14142	C	A	MI.23099	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1806	602	I	M	atC/atA	-0.98	0	0	benign	0.17	neutral	0.25	neutral	0.91	neutral	-0.74	neutral	-0.38	neutral_impact	0	0.88	neutral	0.91	neutral	0.41	6.70	deleterious	0.55	0.6	0.38	neutral	0.05	neutral	0.39	neutral	0.18	neutral	6	0.71	neutral	0.54	deleterious	-6	neutral	0.28	neutral	-0.09	medium_impact	-0.03	medium_impact	-1.2	low_impact	0.61	0.8	NA	NA	0.5	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8635	8635	C	T	MI.231	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	109	37	L	F	Ctc/Ttc	-1.26	0	0	benign	0.03	neutral	0.44	neutral	4.28	neutral	-2.25	neutral	-1.26	low_impact	1.08	0.88	neutral	0.67	neutral	1.76	14.75	neutral	0.51	0.65	0.55	disease	0.5	neutral	0.55	disease	0.52	disease	0	0.53	neutral	0.71	deleterious	-6	neutral	0.25	neutral	0.68	medium_impact	0.23	medium_impact	-0.17	medium_impact	0.58	0.9	20.35	20.89	0.28	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6105	6105	T	A	MI.2310	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	202	68	F	I	Ttc/Atc	0.59	0.99	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.75	deleterious	-3.87	high_impact	5.1	0.71	neutral	0.17	damaging	4.20	23.90	deleterious	0.19	0.55	0.61	disease	0.91	disease	0.67	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.61	high_impact	0.59	0.9	3.9	6.74	0.69	P	0.88	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14143	14143	A	C	MI.23100	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1807	603	T	P	Aca/Cca	-5.79	0	0	unknown	NA	neutral	0.21	neutral	3.71	neutral	-1.8	neutral	-2.16	neutral_impact	0	0.37	damaging	0.28	damaging	2.22	17.64	deleterious	0.25	0.45	NA	NA	0.32	neutral	0.5	neutral	0.22	neutral	6	0.79	neutral	0.61	deleterious	-4	neutral	0.37	neutral	2.1	high_impact	-0.09	medium_impact	-1.2	low_impact	0.77	0.85	NA	NA	0.56	P	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14143	14143	A	T	MI.23101	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1807	603	T	S	Aca/Tca	-5.79	0	0	unknown	NA	neutral	0.44	neutral	3.79	neutral	-0.21	neutral	-1.07	neutral_impact	0	0.79	neutral	0.95	neutral	0.31	5.83	deleterious	0.49	0.55	NA	NA	0.02	neutral	0.24	neutral	0.13	neutral	7	0.56	neutral	0.72	deleterious	-4	neutral	0.34	neutral	2.1	high_impact	0.18	medium_impact	-1.2	low_impact	0.76	0.85	NA	NA	0.43	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14143	14143	A	G	MI.23102	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1807	603	T	A	Aca/Gca	-5.79	0	0	unknown	NA	neutral	0.53	neutral	3.82	neutral	0.12	neutral	-1.03	neutral_impact	0	0.51	damaging	0.36	neutral	2.21	17.57	deleterious	0.53	0.6	NA	NA	0.09	neutral	0.49	neutral	0.14	neutral	7	0.47	neutral	0.77	deleterious	-4	neutral	0.37	neutral	2.1	high_impact	0.26	medium_impact	-1.2	low_impact	0.50	0.8	NA	NA	0.38	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14144	14144	C	T	MI.23103	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1808	603	T	M	aCa/aTa	-1.67	0	0	unknown	NA	neutral	0.23	neutral	3.71	neutral	-1.93	neutral	-0.01	neutral_impact	0	0.53	damaging	0.28	damaging	2.80	21.30	deleterious	0.37	0.5	NA	NA	0.2	neutral	0.38	neutral	0.27	neutral	5	0.77	neutral	0.62	deleterious	-4	neutral	0.39	neutral	2.1	high_impact	-0.06	medium_impact	-1.2	low_impact	0.72	0.85	NA	NA	0.45	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14144	14144	C	A	MI.23104	MT-ND5	I	ENSG00000198786	ENSP00000354813	ENST00000361567	NU5M_HUMAN	P03915	4540	YP_003024036.1	1808	603	T	K	aCa/aAa	-1.67	0	0	unknown	NA	neutral	0.29	neutral	3.76	neutral	-0.65	neutral	-1.95	neutral_impact	0	0.44	damaging	0.29	neutral	3.25	22.80	deleterious	0.27	0.45	NA	NA	0.31	neutral	0.57	disease	0.25	neutral	5	0.71	neutral	0.65	deleterious	-4	neutral	0.41	neutral	2.1	high_impact	0.02	medium_impact	-1.2	low_impact	0.49	0.8	NA	NA	0.46	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14152	14152	A	T	MI.23105	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	522	174	N	K	aaT/aaA	-0.06	0.06	0	probably_damaging	1	neutral	0.62	neutral	2.29	neutral	-0.63	deleterious	-3.04	low_impact	1.34	0.85	neutral	0.75	neutral	4.07	23.70	deleterious	0.66	0.7	0.19	neutral	0.39	neutral	0.43	neutral	0.36	neutral	3	1	deleterious	0.31	neutral	-2	neutral	0.86	deleterious	-3.55	low_impact	0.32	medium_impact	-0.02	medium_impact	0.80	0.85	20.8	19.14	0.28	N	0.89	NA	NA	0.07	rs28357669	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14153	14153	T	C	MI.23106	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	521	174	N	S	aAt/aGt	0.4	0.01	0	probably_damaging	0.99	neutral	0.66	neutral	2.26	neutral	-1.06	neutral	-2.45	neutral_impact	0.69	0.89	neutral	0.87	neutral	1.31	12.34	neutral	0.59	0.65	0.12	neutral	0.17	neutral	0.27	neutral	0.17	neutral	7	0.99	deleterious	0.34	neutral	-2	neutral	0.85	deleterious	-2.63	low_impact	0.37	medium_impact	-0.56	medium_impact	0.71	0.85	20.8	19.14	0.35	N	0.68	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14153	14153	T	G	MI.23107	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	521	174	N	T	aAt/aCt	0.4	0.01	0	probably_damaging	0.99	neutral	0.59	neutral	2.24	neutral	-1.46	deleterious	-3.3	medium_impact	2.24	0.85	neutral	0.82	neutral	3.67	23.30	deleterious	0.45	0.55	0.24	neutral	0.28	neutral	0.43	neutral	0.34	neutral	3	0.99	deleterious	0.3	neutral	1	deleterious	0.85	deleterious	-2.63	low_impact	0.29	medium_impact	0.74	medium_impact	0.76	0.85	20.8	19.14	0.32	N	0.74	NA	NA	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14153	14153	T	A	MI.23108	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	521	174	N	I	aAt/aTt	0.4	0.01	0	probably_damaging	1	neutral	0.45	neutral	2.2	neutral	-2.44	deleterious	-5.38	low_impact	1.34	0.76	neutral	0.7	neutral	4.31	24.00	deleterious	0.38	0.5	0.44	neutral	0.45	neutral	0.44	neutral	0.42	neutral	2	1	deleterious	0.23	neutral	-2	neutral	0.87	deleterious	-3.55	low_impact	0.16	medium_impact	-0.02	medium_impact	0.74	0.85	20.8	19.14	0.33	N	0.93	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14154	14154	T	C	MI.23109	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	520	174	N	D	Aat/Gat	-1.44	0	0	probably_damaging	0.99	neutral	0.42	neutral	2.28	neutral	-0.88	deleterious	-2.83	low_impact	1.9	0.89	neutral	0.86	neutral	3.69	23.30	deleterious	0.67	0.7	0.13	neutral	0.31	neutral	0.43	neutral	0.36	neutral	3	0.99	deleterious	0.22	neutral	-2	neutral	0.85	deleterious	-2.63	low_impact	0.13	medium_impact	0.45	medium_impact	0.73	0.85	20.8	19.14	0.42	N	0.81	NA	NA	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6106	6106	T	G	MI.2311	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	203	68	F	C	tTc/tGc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-6.03	deleterious	-5.16	high_impact	4.75	0.67	neutral	0.14	damaging	3.98	23.60	deleterious	0.19	0.55	0.91	disease	0.88	disease	0.69	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.44	0.9	3.9	6.74	0.66	P	0.91	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14154	14154	T	G	MI.23110	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	520	174	N	H	Aat/Cat	-1.44	0	0	probably_damaging	1	neutral	0.57	neutral	2.22	neutral	-1.29	deleterious	-2.78	low_impact	1.14	0.86	neutral	0.81	neutral	3.55	23.10	deleterious	0.47	0.55	0.38	neutral	0.11	neutral	0.29	neutral	0.16	neutral	7	1	deleterious	0.29	neutral	-2	neutral	0.86	deleterious	-3.55	low_impact	0.27	medium_impact	-0.19	medium_impact	0.68	0.85	20.8	19.14	0.33	N	0.60	NA	NA	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14154	14154	T	A	MI.23111	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	520	174	N	Y	Aat/Tat	-1.44	0	0	probably_damaging	1	neutral	1	neutral	2.19	neutral	-2.48	deleterious	-4.57	low_impact	1.69	0.74	neutral	0.69	neutral	4.38	24.10	deleterious	0.38	0.5	0.5	disease	0.46	neutral	0.54	disease	0.4	neutral	2	1	deleterious	0.5	deleterious	-2	neutral	0.87	deleterious	-3.55	low_impact	1.87	high_impact	0.28	medium_impact	0.74	0.85	20.8	19.14	0.23	N	0.90	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14156	14156	C	G	MI.23112	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	518	173	G	A	gGg/gCg	-11.52	0	0	probably_damaging	1	neutral	0.86	neutral	1.06	deleterious	-5.15	deleterious	-5.1	medium_impact	3.26	0.62	neutral	0.16	damaging	3.59	23.20	deleterious	0.22	0.45	0.4	neutral	0.5	disease	0.61	disease	0.64	disease	3	1	deleterious	0.43	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	0.64	medium_impact	1.59	medium_impact	0.74	0.85	48.67	8.82	0.23	N	0.68	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14156	14156	C	A	MI.23113	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	518	173	G	V	gGg/gTg	-11.52	0	0	probably_damaging	1	neutral	0.61	neutral	1	deleterious	-6.53	deleterious	-7.78	medium_impact	3.46	0.38	damaging	0.05	damaging	4.44	24.20	deleterious	0.14	0.4	0.6	disease	0.73	disease	0.71	disease	0.74	disease	5	1	deleterious	0.31	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	0.31	medium_impact	1.76	medium_impact	0.63	0.8	48.67	8.82	0.25	N	0.94	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14156	14156	C	T	MI.23114	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	518	173	G	E	gGg/gAg	-11.52	0	0	probably_damaging	1	neutral	1	neutral	1.01	deleterious	-6.13	deleterious	-6.7	medium_impact	3.46	0.52	damaging	0.06	damaging	4.41	24.10	deleterious	0.21	0.45	0.27	neutral	0.73	disease	0.69	disease	0.69	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.78	deleterious	-3.55	low_impact	1.87	high_impact	1.76	medium_impact	0.71	0.85	48.67	8.82	0.22	N	0.89	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14157	14157	C	A	MI.23115	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	517	173	G	W	Ggg/Tgg	3.15	0.84	0	probably_damaging	1	neutral	0.07	neutral	0.97	deleterious	-9.26	deleterious	-7.06	medium_impact	3.46	0.51	damaging	0.06	damaging	5.11	25.30	deleterious	0.17	0.45	0.91	disease	0.76	disease	0.72	disease	0.8	disease	6	1	deleterious	0.04	neutral	1	deleterious	0.85	deleterious	-3.55	low_impact	-0.42	medium_impact	1.76	medium_impact	0.49	0.8	48.67	8.82	0.34	N	0.93	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14157	14157	C	G	MI.23116	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	517	173	G	R	Ggg/Cgg	3.15	0.84	0	probably_damaging	1	neutral	0.7	neutral	0.99	deleterious	-6.75	deleterious	-6.79	high_impact	3.81	0.47	damaging	0.05	damaging	4.46	24.20	deleterious	0.19	0.45	0.49	neutral	0.68	disease	0.69	disease	0.7	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.80	deleterious	-3.55	low_impact	0.41	medium_impact	2.05	high_impact	0.79	0.85	48.67	8.82	0.31	N	0.93	NA	NA	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14159	14159	C	G	MI.23117	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	515	172	R	P	cGg/cCg	-2.12	0	0	probably_damaging	1	neutral	0.29	neutral	1.68	deleterious	-6.48	deleterious	-6.96	high_impact	3.92	0.57	damaging	0.17	damaging	4.75	24.70	deleterious	0.51	0.6	0.71	disease	0.86	disease	0.76	disease	0.8	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.01	medium_impact	2.14	high_impact	0.69	0.85	49.56	8.68	0.36	N	0.98	NA	NA	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14159	14159	C	T	MI.23118	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	515	172	R	Q	cGg/cAg	-2.12	0	0	probably_damaging	1	neutral	0.6	neutral	1.73	deleterious	-5.02	deleterious	-3.95	high_impact	3.92	0.71	neutral	0.18	damaging	5.08	25.30	deleterious	0.66	0.7	0.48	neutral	0.78	disease	0.77	disease	0.76	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.79	deleterious	-3.55	low_impact	0.3	medium_impact	2.14	high_impact	0.97	1	49.56	8.68	0.3	N	0.99	NA	NA	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14159	14159	C	A	MI.23119	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	515	172	R	L	cGg/cTg	-2.12	0	0	probably_damaging	1	neutral	0.36	neutral	1.72	deleterious	-5.53	deleterious	-6.96	high_impact	3.58	0.59	damaging	0.21	damaging	5.04	25.20	deleterious	0.57	0.65	0.6	disease	0.89	disease	0.75	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.07	medium_impact	1.86	medium_impact	0.73	0.85	49.56	8.68	0.33	N	1.00	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6106	6106	T	C	MI.2312	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	203	68	F	S	tTc/tCc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-4.42	deleterious	-5.16	high_impact	4.55	0.76	neutral	0.18	damaging	4.14	23.80	deleterious	0.22	0.55	0.85	disease	0.86	disease	0.66	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.59	0.9	3.9	6.74	0.56	P	0.84	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14160	14160	G	A	MI.23120	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	514	172	R	W	Cgg/Tgg	3.15	0.99	0	probably_damaging	1	deleterious	0.02	neutral	1.67	deleterious	-8.34	deleterious	-7.95	high_impact	3.58	0.54	damaging	0.12	damaging	5.14	25.40	deleterious	0.46	0.55	0.9	disease	0.85	disease	0.74	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.55	low_impact	-0.73	medium_impact	1.86	medium_impact	0.84	0.9	49.56	8.68	0.43	N	1.00	NA	NA	0.28	.	.	.	.	.	.	COSM1155545	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14160	14160	G	C	MI.23121	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	514	172	R	G	Cgg/Ggg	3.15	0.99	0	probably_damaging	1	neutral	0.39	neutral	1.69	deleterious	-5.75	deleterious	-6.96	high_impact	3.92	0.6	damaging	0.29	neutral	4.23	23.90	deleterious	0.54	0.6	0.6	disease	0.76	disease	0.75	disease	0.77	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.80	deleterious	-3.55	low_impact	0.1	medium_impact	2.14	high_impact	0.71	0.85	49.56	8.68	0.41	N	0.87	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14162	14162	G	T	MI.23122	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	512	171	A	D	gCt/gAt	-1.44	0	0.02	possibly_damaging	0.5	neutral	0.63	neutral	2.12	deleterious	-4.72	neutral	-1.27	low_impact	1.15	0.78	neutral	0.5	neutral	4.02	23.60	deleterious	0.39	0.5	0.36	neutral	0.62	disease	0.56	disease	0.69	disease	4	0.43	neutral	0.57	deleterious	-3	neutral	0.49	deleterious	-0.8	medium_impact	0.34	medium_impact	-0.18	medium_impact	0.63	0.8	17.26	16.43	0.19	N	0.79	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14162	14162	G	C	MI.23123	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	512	171	A	G	gCt/gGt	-1.44	0	0.02	benign	0.27	neutral	0.47	neutral	2.16	deleterious	-3.95	neutral	-2.16	low_impact	0.8	0.74	neutral	0.64	neutral	2.35	18.52	deleterious	0.41	0.5	0.32	neutral	0.34	neutral	0.49	neutral	0.45	neutral	1	0.43	neutral	0.6	deleterious	-6	neutral	0.31	neutral	-0.4	medium_impact	0.18	medium_impact	-0.47	medium_impact	0.84	0.9	17.26	16.43	0.35	N	0.53	NA	NA	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14162	14162	G	A	MI.23124	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	512	171	A	V	gCt/gTt	-1.44	0	0.02	benign	0.01	neutral	0.48	neutral	2.26	deleterious	-3.77	neutral	0.34	neutral_impact	-1.3	0.92	neutral	0.96	neutral	1.31	12.34	neutral	0.52	0.6	0.12	neutral	0.11	neutral	0.38	neutral	0.32	neutral	4	0.51	neutral	0.74	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.19	medium_impact	-2.23	low_impact	0.75	0.85	17.26	16.43	0.39	N	0.18	NA	NA	0.18	.	.	.	.	.	.	COSM1155548	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14163	14163	C	G	MI.23125	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	511	171	A	P	Gct/Cct	-0.06	0	0	possibly_damaging	0.66	neutral	0.35	neutral	2.12	deleterious	-5.07	neutral	-1.22	low_impact	1.15	0.76	neutral	0.42	neutral	4.20	23.90	deleterious	0.34	0.5	0.44	neutral	0.68	disease	0.52	disease	0.61	disease	2	0.71	neutral	0.35	neutral	-3	neutral	0.61	deleterious	-1.06	low_impact	0.06	medium_impact	-0.18	medium_impact	0.81	0.85	17.26	16.43	0.31	N	0.76	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14163	14163	C	T	MI.23126	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	511	171	A	T	Gct/Act	-0.06	0	0	benign	0.01	neutral	0.68	neutral	2.33	deleterious	-3.67	neutral	4.16	neutral_impact	-2.46	0.97	neutral	0.97	neutral	0.12	3.79	deleterious	0.61	0.65	0.09	neutral	0.03	neutral	0.31	neutral	0.17	neutral	7	0.31	neutral	0.84	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	0.39	medium_impact	-3.2	low_impact	0.85	0.9	17.26	16.43	0.33	N	0.24	NA	NA	0.18	.	.	.	.	.	.	.	.	.	C14163T	Possible deafness factor	+	-	Conflicting reports	2	.	N	N	neutral
chrM	14163	14163	C	A	MI.23127	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	511	171	A	S	Gct/Tct	-0.06	0	0	benign	0.2	neutral	0.85	neutral	2.35	deleterious	-3.23	neutral	0.64	neutral_impact	0.26	0.84	neutral	0.79	neutral	2.83	21.50	deleterious	0.47	0.55	0.21	neutral	0.29	neutral	0.33	neutral	0.42	neutral	2	0.1	neutral	0.83	deleterious	-6	neutral	0.26	neutral	-0.24	medium_impact	0.63	medium_impact	-0.92	medium_impact	0.76	0.85	17.26	16.43	0.25	N	0.58	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14164	14164	A	T	MI.23128	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	510	170	I	M	atT/atA	0.4	0	0	probably_damaging	0.92	neutral	0.11	neutral	1.86	deleterious	-4.19	deleterious	-2.65	medium_impact	2.49	0.79	neutral	0.66	neutral	3.69	23.30	deleterious	0.48	0.55	0.48	neutral	0.35	neutral	0.54	disease	0.47	neutral	1	0.97	neutral	0.1	neutral	1	deleterious	0.69	deleterious	-1.77	low_impact	-0.3	medium_impact	0.95	medium_impact	0.83	0.85	48.67	8.89	0.39	N	0.84	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14164	14164	A	C	MI.23129	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	510	170	I	M	atT/atG	0.4	0	0	probably_damaging	0.92	neutral	0.11	neutral	1.86	deleterious	-4.19	deleterious	-2.65	medium_impact	2.49	0.79	neutral	0.66	neutral	3.54	23.10	deleterious	0.48	0.55	0.48	neutral	0.35	neutral	0.54	disease	0.47	neutral	1	0.97	neutral	0.1	neutral	1	deleterious	0.69	deleterious	-1.77	low_impact	-0.3	medium_impact	0.95	medium_impact	0.83	0.85	48.67	8.89	0.39	N	0.84	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6106	6106	T	A	MI.2313	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	203	68	F	Y	tTc/tAc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-0.39	neutral	-1.93	high_impact	4	0.61	neutral	0.17	damaging	4.13	23.80	deleterious	0.26	0.55	0.68	disease	0.83	disease	0.62	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.59	high_impact	0.67	0.9	3.9	6.74	0.58	P	0.59	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14165	14165	A	G	MI.23130	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	509	170	I	T	aTt/aCt	-0.29	0	0	possibly_damaging	0.84	neutral	0.57	neutral	1.81	deleterious	-4.26	deleterious	-4.44	medium_impact	3.19	0.66	neutral	0.46	neutral	3.93	23.50	deleterious	0.42	0.55	0.53	disease	0.5	disease	0.61	disease	0.69	disease	4	0.82	neutral	0.37	neutral	0	NA	0.73	deleterious	-1.46	low_impact	0.27	medium_impact	1.53	medium_impact	0.65	0.8	48.67	8.89	0.31	N	0.91	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14165	14165	A	C	MI.23131	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	509	170	I	S	aTt/aGt	-0.29	0	0	probably_damaging	0.9	neutral	0.73	neutral	1.8	deleterious	-4.68	deleterious	-5.67	medium_impact	2.84	0.68	neutral	0.53	neutral	4.37	24.10	deleterious	0.3	0.45	0.68	disease	0.72	disease	0.63	disease	0.73	disease	5	0.89	neutral	0.42	neutral	1	deleterious	0.81	deleterious	-1.67	low_impact	0.45	medium_impact	1.24	medium_impact	0.53	0.8	48.67	8.89	0.3	N	0.97	NA	NA	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14165	14165	A	T	MI.23132	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	509	170	I	N	aTt/aAt	-0.29	0	0	probably_damaging	0.97	neutral	0.49	neutral	1.79	deleterious	-5.64	deleterious	-6.67	medium_impact	3.19	0.64	neutral	0.49	neutral	4.56	24.40	deleterious	0.28	0.45	0.8	disease	0.74	disease	0.63	disease	0.76	disease	5	0.97	neutral	0.26	neutral	1	deleterious	0.84	deleterious	-2.18	low_impact	0.2	medium_impact	1.53	medium_impact	0.58	0.8	48.67	8.89	0.31	N	0.99	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14166	14166	T	C	MI.23133	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	508	170	I	V	Att/Gtt	5.44	0.54	0	possibly_damaging	0.44	neutral	0.3	neutral	1.86	neutral	-1.8	neutral	-0.52	low_impact	1.02	0.89	neutral	0.98	neutral	1.69	14.36	neutral	0.46	0.55	0.11	neutral	0.11	neutral	0.34	neutral	0.29	neutral	4	0.66	neutral	0.43	neutral	-3	neutral	0.38	neutral	-0.7	medium_impact	0	medium_impact	-0.29	medium_impact	0.70	0.85	48.67	8.89	0.5	N	0.13	NA	NA	0.20	.	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14166	14166	T	G	MI.23134	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	508	170	I	L	Att/Ctt	5.44	0.54	0	benign	0.03	neutral	0.35	neutral	2.14	neutral	-2.08	neutral	-1.86	neutral_impact	0.14	0.82	neutral	0.77	neutral	3.28	22.80	deleterious	0.37	0.5	0.14	neutral	0.11	neutral	0.29	neutral	0.23	neutral	5	0.63	neutral	0.66	deleterious	-6	neutral	0.12	neutral	0.59	medium_impact	0.06	medium_impact	-1.02	low_impact	0.68	0.85	48.67	8.89	0.49	N	0.63	NA	NA	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14166	14166	T	A	MI.23135	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	508	170	I	F	Att/Ttt	5.44	0.54	0	possibly_damaging	0.83	neutral	0.07	neutral	1.8	deleterious	-4.31	deleterious	-3.92	medium_impact	3.19	0.7	neutral	0.5	neutral	4.64	24.50	deleterious	0.37	0.5	0.54	disease	0.67	disease	0.63	disease	0.73	disease	5	0.96	neutral	0.12	neutral	0	NA	0.75	deleterious	-1.43	low_impact	-0.42	medium_impact	1.53	medium_impact	0.77	0.85	48.67	8.89	0.52	N	0.91	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14167	14167	C	A	MI.23136	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	507	169	E	D	gaG/gaT	-1.89	0	0.06	probably_damaging	1	neutral	0.53	neutral	2.25	deleterious	-3.1	deleterious	-2.95	medium_impact	2.94	0.8	neutral	0.38	neutral	4.64	24.50	deleterious	0.41	0.5	0.46	neutral	0.82	disease	0.6	disease	0.66	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.83	deleterious	-3.55	low_impact	0.24	medium_impact	1.32	medium_impact	0.83	0.9	50.88	8.57	0.22	N	0.83	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14167	14167	C	G	MI.23137	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	507	169	E	D	gaG/gaC	-1.89	0	0.06	probably_damaging	1	neutral	0.53	neutral	2.25	deleterious	-3.1	deleterious	-2.95	medium_impact	2.94	0.8	neutral	0.38	neutral	4.23	23.90	deleterious	0.41	0.5	0.46	neutral	0.82	disease	0.6	disease	0.66	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.83	deleterious	-3.55	low_impact	0.24	medium_impact	1.32	medium_impact	0.83	0.9	50.88	8.57	0.22	N	0.83	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14168	14168	T	C	MI.23138	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	506	169	E	G	gAg/gGg	-0.75	0	0	probably_damaging	1	neutral	0.58	neutral	2.25	deleterious	-4.34	deleterious	-6.86	medium_impact	3.21	0.71	neutral	0.52	neutral	4.54	24.30	deleterious	0.39	0.5	0.6	disease	0.85	disease	0.65	disease	0.7	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.84	deleterious	-3.55	low_impact	0.28	medium_impact	1.55	medium_impact	0.66	0.8	50.88	8.57	0.25	N	0.29	NA	NA	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14168	14168	T	G	MI.23139	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	506	169	E	A	gAg/gCg	-0.75	0	0	probably_damaging	1	neutral	1	neutral	2.34	deleterious	-3.9	deleterious	-5.86	high_impact	3.91	0.66	neutral	0.47	neutral	4.40	24.10	deleterious	0.35	0.5	0.48	neutral	0.86	disease	0.66	disease	0.75	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.55	low_impact	1.87	high_impact	2.14	high_impact	0.79	0.85	50.88	8.57	0.29	N	0.64	NA	NA	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6107	6107	C	G	MI.2314	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	204	68	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-2.72	deleterious	-3.87	medium_impact	3.06	0.57	damaging	0.18	damaging	4.23	23.90	deleterious	0.34	0.55	0.26	neutral	0.81	disease	0.59	disease	0.69	disease	4	1	deleterious	0	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	1.73	medium_impact	0.68	0.9	3.9	6.74	0.47	N	0.83	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14168	14168	T	A	MI.23140	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	506	169	E	V	gAg/gTg	-0.75	0	0	probably_damaging	1	neutral	0.68	neutral	2.32	deleterious	-4.86	deleterious	-6.86	medium_impact	3.21	0.67	neutral	0.35	neutral	4.86	24.90	deleterious	0.3	0.45	0.6	disease	0.94	disease	0.69	disease	0.83	disease	7	1	deleterious	0.34	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	0.39	medium_impact	1.55	medium_impact	0.81	0.85	50.88	8.57	0.3	N	0.72	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14169	14169	C	G	MI.23141	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	505	169	E	Q	Gag/Cag	1.77	0.06	0	probably_damaging	1	neutral	0.61	neutral	2.26	deleterious	-4.06	deleterious	-2.77	high_impact	3.56	0.79	neutral	0.39	neutral	3.71	23.30	deleterious	0.47	0.55	0.51	disease	0.83	disease	0.68	disease	0.73	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	0.31	medium_impact	1.84	medium_impact	0.87	0.9	50.88	8.57	0.26	N	0.87	NA	NA	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14169	14169	C	T	MI.23142	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	505	169	E	K	Gag/Aag	1.77	0.06	0	probably_damaging	1	neutral	0.8	neutral	2.58	deleterious	-3.58	deleterious	-3.85	medium_impact	3.21	0.75	neutral	0.26	damaging	4.88	24.90	deleterious	0.38	0.5	0.42	neutral	0.93	disease	0.72	disease	0.84	disease	7	1	deleterious	0.4	neutral	1	deleterious	0.87	deleterious	-3.55	low_impact	0.54	medium_impact	1.55	medium_impact	0.92	0.95	50.88	8.57	0.31	N	0.93	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14170	14170	A	T	MI.23143	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	504	168	I	M	atT/atA	1.54	0.06	0	probably_damaging	1	neutral	0.23	neutral	1.99	neutral	-1.12	neutral	-0.8	low_impact	1.24	0.87	neutral	0.92	neutral	1.52	13.43	neutral	0.47	0.55	0.18	neutral	0.4	neutral	0.26	neutral	0.45	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.67	deleterious	-3.55	low_impact	-0.09	medium_impact	-0.1	medium_impact	0.91	0.95	48.23	8.83	0.45	N	0.17	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14170	14170	A	C	MI.23144	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	504	168	I	M	atT/atG	1.54	0.06	0	probably_damaging	1	neutral	0.23	neutral	1.99	neutral	-1.12	neutral	-0.8	low_impact	1.24	0.87	neutral	0.92	neutral	1.38	12.68	neutral	0.47	0.55	0.18	neutral	0.4	neutral	0.26	neutral	0.45	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.67	deleterious	-3.55	low_impact	-0.09	medium_impact	-0.1	medium_impact	0.91	0.95	48.23	8.83	0.43	N	0.17	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14171	14171	A	G	MI.23145	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	503	168	I	T	aTt/aCt	-4.87	0	0	probably_damaging	1	neutral	0.46	neutral	2.02	neutral	-2.87	deleterious	-3.77	medium_impact	2.69	0.84	neutral	0.4	neutral	3.70	23.30	deleterious	0.54	0.6	0.53	disease	0.63	disease	0.51	disease	0.59	disease	2	1	deleterious	0.23	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	0.17	medium_impact	1.11	medium_impact	0.79	0.85	48.23	8.83	0.25	N	0.91	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14171	14171	A	C	MI.23146	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	503	168	I	S	aTt/aGt	-4.87	0	0	probably_damaging	1	neutral	0.48	neutral	2.03	deleterious	-3.5	deleterious	-4.59	medium_impact	2.69	0.75	neutral	0.24	damaging	4.14	23.80	deleterious	0.37	0.5	0.65	disease	0.83	disease	0.52	disease	0.78	disease	6	1	deleterious	0.24	neutral	1	deleterious	0.83	deleterious	-3.55	low_impact	0.19	medium_impact	1.11	medium_impact	0.61	0.8	48.23	8.83	0.25	N	0.88	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14171	14171	A	T	MI.23147	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	503	168	I	N	aTt/aAt	-4.87	0	0	probably_damaging	1	neutral	0.36	neutral	1.97	deleterious	-4.54	deleterious	-5.59	medium_impact	3.04	0.72	neutral	0.2	damaging	4.46	24.20	deleterious	0.4	0.5	0.78	disease	0.87	disease	0.55	disease	0.79	disease	6	1	deleterious	0.18	neutral	1	deleterious	0.86	deleterious	-3.55	low_impact	0.07	medium_impact	1.41	medium_impact	0.64	0.8	48.23	8.83	0.25	N	0.90	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14172	14172	T	C	MI.23148	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	502	168	I	V	Att/Gtt	4.52	0.56	0	probably_damaging	1	neutral	0.53	neutral	2.16	neutral	-0.92	neutral	-0.76	medium_impact	2	0.82	neutral	0.49	neutral	1.91	15.67	deleterious	0.55	0.6	0.22	neutral	0.5	neutral	0.43	neutral	0.51	disease	0	0.99	deleterious	0.27	neutral	1	deleterious	0.68	deleterious	-3.55	low_impact	0.24	medium_impact	0.54	medium_impact	0.77	0.85	48.23	8.83	0.33	N	0.59	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14172	14172	T	G	MI.23149	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	502	168	I	L	Att/Ctt	4.52	0.56	0	probably_damaging	1	neutral	0.69	neutral	2.28	neutral	1.75	neutral	-0.38	neutral_impact	0.44	0.88	neutral	0.88	neutral	2.49	19.40	deleterious	0.44	0.55	0.09	neutral	0.19	neutral	0.29	neutral	0.31	neutral	4	0.99	deleterious	0.35	neutral	-2	neutral	0.64	deleterious	-3.55	low_impact	0.4	medium_impact	-0.77	medium_impact	0.84	0.9	48.23	8.83	0.37	N	0.33	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6107	6107	C	A	MI.2315	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	204	68	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-2.72	deleterious	-3.87	medium_impact	3.06	0.57	damaging	0.18	damaging	4.59	24.40	deleterious	0.34	0.55	0.26	neutral	0.81	disease	0.59	disease	0.69	disease	4	1	deleterious	0	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	1.73	medium_impact	0.68	0.9	3.9	6.74	0.48	N	0.83	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14172	14172	T	A	MI.23150	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	502	168	I	F	Att/Ttt	4.52	0.56	0	probably_damaging	1	neutral	0.71	neutral	1.97	neutral	-1.77	deleterious	-2.86	medium_impact	2.5	0.77	neutral	0.33	neutral	4.29	24.00	deleterious	0.37	0.5	0.41	neutral	0.81	disease	0.46	neutral	0.74	disease	5	1	deleterious	0.36	neutral	1	deleterious	0.80	deleterious	-3.55	low_impact	0.42	medium_impact	0.95	medium_impact	0.86	0.9	48.23	8.83	0.25	N	0.75	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14174	14174	A	C	MI.23151	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	500	167	V	G	gTa/gGa	-8.54	0	0	possibly_damaging	0.67	neutral	0.34	neutral	2.03	deleterious	-5.58	deleterious	-6.15	high_impact	3.56	0.6	neutral	0.51	neutral	3.64	23.20	deleterious	0.18	0.45	0.38	neutral	0.91	disease	0.7	disease	0.8	disease	6	0.73	neutral	0.34	neutral	1	deleterious	0.68	deleterious	-1.08	low_impact	0.05	medium_impact	1.84	medium_impact	0.62	0.8	49.12	8.62	0.41	N	0.88	NA	NA	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14174	14174	A	G	MI.23152	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	500	167	V	A	gTa/gCa	-8.54	0	0	benign	0.05	neutral	0.51	neutral	2.21	deleterious	-3.65	deleterious	-3.09	low_impact	1.73	0.92	neutral	0.86	neutral	2.61	20.30	deleterious	0.33	0.5	0.39	neutral	0.79	disease	0.57	disease	0.58	disease	2	0.44	neutral	0.73	deleterious	-6	neutral	0.28	neutral	0.38	medium_impact	0.22	medium_impact	0.31	medium_impact	0.72	0.85	49.12	8.62	0.31	N	0.41	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14174	14174	A	T	MI.23153	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	500	167	V	E	gTa/gAa	-8.54	0	0	possibly_damaging	0.87	neutral	0.28	neutral	2	deleterious	-5.42	deleterious	-5.34	high_impact	3.56	0.6	neutral	0.42	neutral	4.43	24.20	deleterious	0.13	0.4	0.67	disease	0.95	disease	0.77	disease	0.9	disease	8	0.9	neutral	0.21	neutral	1	deleterious	0.85	deleterious	-1.55	low_impact	-0.02	medium_impact	1.84	medium_impact	0.71	0.85	49.12	8.62	0.42	N	0.90	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14175	14175	C	T	MI.23154	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	499	167	V	M	Gta/Ata	3.15	0.04	0	probably_damaging	0.97	neutral	0.22	neutral	2.06	deleterious	-4.32	neutral	-2.35	high_impact	3.56	0.62	neutral	0.48	neutral	4.11	23.70	deleterious	0.37	0.5	0.51	disease	0.83	disease	0.71	disease	0.76	disease	5	0.98	neutral	0.13	neutral	2	deleterious	0.77	deleterious	-2.18	low_impact	-0.1	medium_impact	1.84	medium_impact	0.90	0.95	49.12	8.62	0.42	N	0.59	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14175	14175	C	G	MI.23155	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	499	167	V	L	Gta/Cta	3.15	0.04	0	possibly_damaging	0.56	neutral	0.65	neutral	2.08	neutral	-2.44	neutral	-1.96	high_impact	3.56	0.59	damaging	0.47	neutral	3.95	23.60	deleterious	0.33	0.5	0.28	neutral	0.88	disease	0.67	disease	0.76	disease	5	0.48	neutral	0.55	deleterious	1	deleterious	0.65	deleterious	-0.89	medium_impact	0.36	medium_impact	1.84	medium_impact	0.77	0.85	49.12	8.62	0.4	N	0.63	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14175	14175	C	A	MI.23156	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	499	167	V	L	Gta/Tta	3.15	0.04	0	possibly_damaging	0.56	neutral	0.65	neutral	2.08	neutral	-2.44	neutral	-1.96	high_impact	3.56	0.59	damaging	0.47	neutral	4.24	23.90	deleterious	0.33	0.5	0.28	neutral	0.88	disease	0.67	disease	0.76	disease	5	0.48	neutral	0.55	deleterious	1	deleterious	0.65	deleterious	-0.89	medium_impact	0.36	medium_impact	1.84	medium_impact	0.77	0.85	49.12	8.62	0.38	N	0.63	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14176	14176	A	T	MI.23157	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	498	166	I	M	atT/atA	0.63	0	0	possibly_damaging	0.86	neutral	0.23	neutral	2.22	deleterious	-3.42	deleterious	-2.7	medium_impact	3.19	0.7	neutral	0.48	neutral	3.09	22.50	deleterious	0.47	0.55	0.49	neutral	0.78	disease	0.63	disease	0.77	disease	5	0.9	neutral	0.19	neutral	0	NA	0.71	deleterious	-1.52	low_impact	-0.09	medium_impact	1.53	medium_impact	0.88	0.9	49.56	8.89	0.37	N	0.76	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14176	14176	A	C	MI.23158	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	498	166	I	M	atT/atG	0.63	0	0	possibly_damaging	0.86	neutral	0.23	neutral	2.22	deleterious	-3.42	deleterious	-2.7	medium_impact	3.19	0.7	neutral	0.48	neutral	3.02	22.30	deleterious	0.47	0.55	0.49	neutral	0.78	disease	0.63	disease	0.77	disease	5	0.9	neutral	0.19	neutral	0	NA	0.71	deleterious	-1.52	low_impact	-0.09	medium_impact	1.53	medium_impact	0.88	0.9	49.56	8.89	0.36	N	0.76	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14177	14177	A	G	MI.23159	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	497	166	I	T	aTt/aCt	-3.04	0	0	possibly_damaging	0.58	neutral	0.45	neutral	2.25	deleterious	-3.37	deleterious	-4.4	medium_impact	3.19	0.75	neutral	0.69	neutral	2.12	16.97	deleterious	0.53	0.6	0.46	neutral	0.82	disease	0.55	disease	0.74	disease	5	0.59	neutral	0.44	neutral	0	NA	0.57	deleterious	-0.92	medium_impact	0.16	medium_impact	1.53	medium_impact	0.80	0.85	49.56	8.89	0.4	N	0.78	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6108	6108	A	G	MI.2316	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	205	69	M	V	Ata/Gta	-2.65	0	0	benign	0.08	deleterious	0	neutral	2.93	neutral	1.32	neutral	-2.19	medium_impact	2.72	0.58	damaging	0.09	damaging	0.79	9.40	deleterious	0.53	0.6	0.19	neutral	0.9	disease	0.47	neutral	0.53	disease	1	1	deleterious	0.46	neutral	1	deleterious	0.26	neutral	0.24	medium_impact	-1.48	low_impact	1.41	medium_impact	0.49	0.9	7.02	12.6	0.28	N	0.73	disease_causing	0.76	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14177	14177	A	C	MI.23160	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	497	166	I	S	aTt/aGt	-3.04	0	0	possibly_damaging	0.81	neutral	0.51	neutral	2.31	deleterious	-4.16	deleterious	-5.69	medium_impact	2.85	0.73	neutral	0.55	neutral	3.95	23.60	deleterious	0.34	0.5	0.59	disease	0.92	disease	0.61	disease	0.81	disease	6	0.79	neutral	0.35	neutral	0	NA	0.76	deleterious	-1.37	low_impact	0.22	medium_impact	1.25	medium_impact	0.69	0.85	49.56	8.89	0.3	N	0.85	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14177	14177	A	T	MI.23161	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	497	166	I	N	aTt/aAt	-3.04	0	0	probably_damaging	0.92	neutral	0.37	neutral	2.19	deleterious	-5.21	deleterious	-6.69	medium_impact	3.19	0.72	neutral	0.51	neutral	4.30	24.00	deleterious	0.35	0.5	0.74	disease	0.95	disease	0.63	disease	0.84	disease	7	0.93	neutral	0.23	neutral	1	deleterious	0.83	deleterious	-1.77	low_impact	0.08	medium_impact	1.53	medium_impact	0.74	0.85	49.56	8.89	0.29	N	0.95	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14178	14178	T	A	MI.23162	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	496	166	I	F	Att/Ttt	3.61	0.1	0.02	possibly_damaging	0.81	neutral	0.71	neutral	2.25	deleterious	-3.73	deleterious	-3.99	medium_impact	3.19	0.75	neutral	0.54	neutral	4.12	23.80	deleterious	0.38	0.5	0.54	disease	0.92	disease	0.64	disease	0.82	disease	6	0.78	neutral	0.45	neutral	0	NA	0.74	deleterious	-1.37	low_impact	0.42	medium_impact	1.53	medium_impact	0.87	0.9	49.56	8.89	0.29	N	0.87	NA	NA	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14178	14178	T	G	MI.23163	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	496	166	I	L	Att/Ctt	3.61	0.1	0.02	benign	0.23	neutral	0.69	neutral	2.3	neutral	-1.41	neutral	-1.99	medium_impact	2.85	0.85	neutral	0.56	neutral	2.28	18.05	deleterious	0.36	0.5	0.24	neutral	0.81	disease	0.59	disease	0.78	disease	6	0.2	neutral	0.73	deleterious	-3	neutral	0.31	neutral	-0.32	medium_impact	0.4	medium_impact	1.25	medium_impact	0.82	0.85	49.56	8.89	0.36	N	0.66	NA	NA	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14178	14178	T	C	MI.23164	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	496	166	I	V	Att/Gtt	3.61	0.1	0.02	benign	0.02	neutral	0.54	neutral	2.34	neutral	0.95	neutral	-0.42	neutral_impact	0.22	0.97	neutral	0.99	neutral	-0.80	0.04	neutral	0.49	0.55	0.1	neutral	0.15	neutral	0.37	neutral	0.23	neutral	5	0.43	neutral	0.76	deleterious	-6	neutral	0.10	neutral	0.75	medium_impact	0.25	medium_impact	-0.96	medium_impact	0.77	0.85	49.56	8.89	0.43	N	0.00	NA	NA	0.20	rs28357671	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14180	14180	T	C	MI.23165	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	494	165	Y	C	tAt/tGt	-0.52	0	0.03	probably_damaging	0.96	neutral	0.18	neutral	2.3	deleterious	-6.77	deleterious	-2.55	low_impact	1.9	0.96	neutral	0.43	neutral	3.45	23.00	deleterious	0.4	0.5	0.38	neutral	0.91	disease	0.56	disease	0.81	disease	6	0.97	neutral	0.11	neutral	-2	neutral	0.78	deleterious	-2.06	low_impact	-0.16	medium_impact	0.45	medium_impact	0.38	0.8	48.67	8.72	0.38	N	0.67	NA	NA	0.57	rs200933339	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14180	14180	T	A	MI.23166	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	494	165	Y	F	tAt/tTt	-0.52	0	0.03	possibly_damaging	0.65	neutral	0.71	neutral	2.42	neutral	-2.93	neutral	1.25	neutral_impact	-0.68	0.88	neutral	0.95	neutral	1.01	10.74	neutral	0.4	0.5	0.09	neutral	0.24	neutral	0.39	neutral	0.39	neutral	2	0.58	neutral	0.53	deleterious	-3	neutral	0.52	deleterious	-1.04	low_impact	0.42	medium_impact	-1.71	low_impact	0.65	0.8	48.67	8.72	0.25	N	0.27	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14180	14180	T	G	MI.23167	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	494	165	Y	S	tAt/tCt	-0.52	0	0.03	possibly_damaging	0.7	neutral	0.44	neutral	2.32	deleterious	-4.84	deleterious	-2.98	medium_impact	2.24	0.84	neutral	0.6	neutral	4.05	23.70	deleterious	0.34	0.5	0.25	neutral	0.86	disease	0.58	disease	0.81	disease	6	0.7	neutral	0.37	neutral	0	NA	0.61	deleterious	-1.13	low_impact	0.15	medium_impact	0.74	medium_impact	0.50	0.8	48.67	8.72	0.29	N	0.75	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14181	14181	A	G	MI.23168	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	493	165	Y	H	Tat/Cat	2.92	0.35	0	benign	0.02	neutral	0.54	neutral	2.3	deleterious	-5.03	deleterious	-2.64	neutral_impact	0.63	0.86	neutral	0.49	neutral	0.70	8.86	deleterious	0.36	0.5	0.41	neutral	0.78	disease	0.6	disease	0.74	disease	5	0.44	neutral	0.76	deleterious	-6	neutral	0.25	neutral	0.75	medium_impact	0.25	medium_impact	-0.61	medium_impact	0.62	0.8	48.67	8.72	0.33	N	0.63	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14181	14181	A	C	MI.23169	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	493	165	Y	D	Tat/Gat	2.92	0.35	0	possibly_damaging	0.76	neutral	0.22	neutral	2.29	deleterious	-5.53	deleterious	-4.16	medium_impact	2.24	0.8	neutral	0.37	neutral	3.62	23.20	deleterious	0.24	0.45	0.53	disease	0.93	disease	0.67	disease	0.83	disease	7	0.85	neutral	0.23	neutral	0	NA	0.77	deleterious	-1.26	low_impact	-0.1	medium_impact	0.74	medium_impact	0.54	0.8	48.67	8.72	0.29	N	0.81	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6108	6108	A	T	MI.2317	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	205	69	M	L	Ata/Tta	-2.65	0	0	benign	0.05	neutral	0.07	neutral	2.94	neutral	1.39	neutral	-1.58	low_impact	1.84	0.59	damaging	0.1	damaging	0.21	4.74	deleterious	0.46	0.55	0.24	neutral	0.77	disease	0.43	neutral	0.52	disease	0	0.93	neutral	0.51	deleterious	-6	neutral	0.25	neutral	0.45	medium_impact	-0.43	medium_impact	0.6	medium_impact	0.54	0.9	7.02	12.6	0.31	N	0.43	disease_causing	0.72	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14181	14181	A	T	MI.23170	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	493	165	Y	N	Tat/Aat	2.92	0.35	0	possibly_damaging	0.63	neutral	0.34	neutral	2.3	deleterious	-5.32	deleterious	-3.85	medium_impact	2.24	0.8	neutral	0.53	neutral	3.58	23.20	deleterious	0.34	0.5	0.4	neutral	0.9	disease	0.59	disease	0.81	disease	6	0.7	neutral	0.36	neutral	0	NA	0.63	deleterious	-1.01	low_impact	0.05	medium_impact	0.74	medium_impact	0.50	0.8	48.67	8.72	0.31	N	0.75	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14183	14183	A	C	MI.23171	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	491	164	V	G	gTa/gGa	-3.5	0	0	possibly_damaging	0.82	neutral	0.67	neutral	2.19	deleterious	-3.2	deleterious	-6.88	medium_impact	2.96	0.86	neutral	0.56	neutral	3.57	23.10	deleterious	0.18	0.45	0.71	disease	0.89	disease	0.65	disease	0.81	disease	6	0.79	neutral	0.43	neutral	0	NA	0.81	deleterious	-1.4	low_impact	0.38	medium_impact	1.34	medium_impact	0.61	0.8	48.67	8.91	0.22	N	0.94	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14183	14183	A	T	MI.23172	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	491	164	V	E	gTa/gAa	-3.5	0	0	probably_damaging	0.91	neutral	0.7	neutral	2.19	deleterious	-3.43	deleterious	-5.88	medium_impact	2.96	0.79	neutral	0.44	neutral	4.33	24.00	deleterious	0.13	0.4	0.71	disease	0.95	disease	0.75	disease	0.91	disease	8	0.89	neutral	0.4	neutral	1	deleterious	0.86	deleterious	-1.72	low_impact	0.41	medium_impact	1.34	medium_impact	0.73	0.85	48.67	8.91	0.22	N	0.94	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14183	14183	A	G	MI.23173	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	491	164	V	A	gTa/gCa	-3.5	0	0	possibly_damaging	0.46	neutral	0.83	neutral	2.24	neutral	-1.28	deleterious	-3.92	medium_impact	2.96	0.77	neutral	0.59	neutral	3.36	22.90	deleterious	0.31	0.45	0.42	neutral	0.77	disease	0.64	disease	0.77	disease	5	0.35	neutral	0.69	deleterious	0	NA	0.61	deleterious	-0.73	medium_impact	0.59	medium_impact	1.34	medium_impact	0.48	0.8	48.67	8.91	0.23	N	0.79	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14184	14184	C	A	MI.23174	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	490	164	V	L	Gta/Tta	7.04	0.69	0	benign	0.14	neutral	0.84	neutral	2.8	neutral	2.37	neutral	-2.21	neutral_impact	0.44	0.78	neutral	0.69	neutral	2.38	18.69	deleterious	0.32	0.5	0.11	neutral	0.27	neutral	0.37	neutral	0.43	neutral	2	0.07	neutral	0.85	deleterious	-6	neutral	0.24	neutral	-0.07	medium_impact	0.61	medium_impact	-0.77	medium_impact	0.68	0.85	48.67	8.91	0.43	N	0.67	NA	NA	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14184	14184	C	G	MI.23175	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	490	164	V	L	Gta/Cta	7.04	0.69	0	benign	0.14	neutral	0.84	neutral	2.8	neutral	2.37	neutral	-2.21	neutral_impact	0.44	0.78	neutral	0.69	neutral	2.09	16.81	deleterious	0.32	0.5	0.11	neutral	0.27	neutral	0.37	neutral	0.43	neutral	2	0.07	neutral	0.85	deleterious	-6	neutral	0.24	neutral	-0.07	medium_impact	0.61	medium_impact	-0.77	medium_impact	0.68	0.85	48.67	8.91	0.44	N	0.67	NA	NA	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14184	14184	C	T	MI.23176	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	490	164	V	M	Gta/Ata	7.04	0.69	0	benign	0.12	neutral	0.28	neutral	2.52	neutral	1.36	neutral	-2.43	low_impact	1.26	0.87	neutral	0.54	neutral	1.22	11.85	neutral	0.37	0.5	0.4	neutral	0.72	disease	0.54	disease	0.64	disease	3	0.68	neutral	0.58	deleterious	-6	neutral	0.28	neutral	0	medium_impact	-0.02	medium_impact	-0.08	medium_impact	0.72	0.85	48.67	8.91	0.45	N	0.61	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14186	14186	C	A	MI.23177	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	488	163	G	V	gGt/gTt	-0.98	0	0	probably_damaging	1	neutral	0.56	neutral	2.67	deleterious	-5.73	deleterious	-5.8	low_impact	1.88	0.74	neutral	0.67	neutral	4.37	24.10	deleterious	0.37	0.5	0.46	neutral	0.9	disease	0.58	disease	0.79	disease	6	1	deleterious	0.28	neutral	-2	neutral	0.85	deleterious	-3.55	low_impact	0.27	medium_impact	0.44	medium_impact	0.77	0.85	49.56	8.85	0.26	N	0.98	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14186	14186	C	T	MI.23178	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	488	163	G	D	gGt/gAt	-0.98	0	0	probably_damaging	1	neutral	0.33	neutral	2.25	deleterious	-5.45	deleterious	-4.16	medium_impact	3.08	0.75	neutral	0.42	neutral	4.23	23.90	deleterious	0.2	0.45	0.45	neutral	0.92	disease	0.69	disease	0.83	disease	7	1	deleterious	0.17	neutral	1	deleterious	0.87	deleterious	-3.55	low_impact	0.04	medium_impact	1.44	medium_impact	0.74	0.85	49.56	8.85	0.36	N	0.96	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14186	14186	C	G	MI.23179	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	488	163	G	A	gGt/gCt	-0.98	0	0	probably_damaging	1	neutral	0.66	neutral	2.54	deleterious	-4.4	deleterious	-2.96	low_impact	1.43	0.81	neutral	0.77	neutral	2.33	18.35	deleterious	0.5	0.6	0.19	neutral	0.71	disease	0.32	neutral	0.55	disease	1	1	deleterious	0.33	neutral	-2	neutral	0.75	deleterious	-3.55	low_impact	0.37	medium_impact	0.06	medium_impact	0.83	0.85	49.56	8.85	0.24	N	0.75	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6108	6108	A	C	MI.2318	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	205	69	M	L	Ata/Cta	-2.65	0	0	benign	0.05	neutral	0.07	neutral	2.94	neutral	1.39	neutral	-1.58	low_impact	1.84	0.59	damaging	0.1	damaging	0.14	4.03	deleterious	0.46	0.55	0.24	neutral	0.77	disease	0.43	neutral	0.52	disease	0	0.93	neutral	0.51	deleterious	-6	neutral	0.25	neutral	0.45	medium_impact	-0.43	medium_impact	0.6	medium_impact	0.54	0.9	7.02	12.6	0.31	N	0.43	disease_causing	0.72	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14187	14187	C	T	MI.23180	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	487	163	G	S	Ggt/Agt	1.31	0	0	probably_damaging	1	neutral	0.55	neutral	2.33	deleterious	-4.66	neutral	-2.12	low_impact	1.28	0.87	neutral	0.95	neutral	2.55	19.82	deleterious	0.41	0.5	0.29	neutral	0.68	disease	0.32	neutral	0.52	disease	0	1	deleterious	0.28	neutral	-2	neutral	0.76	deleterious	-3.55	low_impact	0.26	medium_impact	-0.07	medium_impact	0.93	0.95	49.56	8.85	0.28	N	0.81	NA	NA	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14187	14187	C	G	MI.23181	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	487	163	G	R	Ggt/Cgt	1.31	0	0	probably_damaging	1	neutral	0.49	neutral	2.26	deleterious	-5.95	deleterious	-5.04	medium_impact	3.08	0.71	neutral	0.41	neutral	4.21	23.90	deleterious	0.26	0.45	0.49	neutral	0.93	disease	0.71	disease	0.86	disease	7	1	deleterious	0.25	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	0.2	medium_impact	1.44	medium_impact	0.79	0.85	49.56	8.85	0.29	N	0.96	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14187	14187	C	A	MI.23182	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	487	163	G	C	Ggt/Tgt	1.31	0	0	probably_damaging	1	neutral	0.19	neutral	2.29	deleterious	-7.01	deleterious	-5.13	medium_impact	1.98	0.86	neutral	0.81	neutral	3.52	23.10	deleterious	0.28	0.45	0.68	disease	0.89	disease	0.39	neutral	0.63	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	-0.14	medium_impact	0.52	medium_impact	0.77	0.85	49.56	8.85	0.36	N	0.90	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14189	14189	A	C	MI.23183	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	485	162	V	G	gTt/gGt	-0.52	0	0	possibly_damaging	0.83	neutral	0.34	neutral	2.07	deleterious	-5.02	deleterious	-5.91	medium_impact	2.88	0.76	neutral	0.47	neutral	3.57	23.10	deleterious	0.19	0.45	0.66	disease	0.85	disease	0.66	disease	0.82	disease	6	0.85	neutral	0.26	neutral	0	NA	0.73	deleterious	-1.43	low_impact	0.05	medium_impact	1.27	medium_impact	0.64	0.8	49.56	8.89	0.28	N	0.86	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14189	14189	A	G	MI.23184	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	485	162	V	A	gTt/gCt	-0.52	0	0	possibly_damaging	0.47	neutral	0.52	neutral	2.17	deleterious	-3.61	deleterious	-2.95	low_impact	1.9	0.84	neutral	0.86	neutral	0.67	8.62	deleterious	0.37	0.5	0.22	neutral	0.7	disease	0.62	disease	0.74	disease	5	0.46	neutral	0.53	deleterious	-3	neutral	0.49	deleterious	-0.75	medium_impact	0.23	medium_impact	0.45	medium_impact	0.48	0.8	49.56	8.89	0.25	N	0.38	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14189	14189	A	T	MI.23185	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	485	162	V	D	gTt/gAt	-0.52	0	0	possibly_damaging	0.88	neutral	0.21	neutral	2.05	deleterious	-5.67	deleterious	-5.71	medium_impact	2.88	0.77	neutral	0.43	neutral	4.38	24.10	deleterious	0.11	0.4	0.76	disease	0.91	disease	0.76	disease	0.85	disease	7	0.93	neutral	0.17	neutral	0	NA	0.82	deleterious	-1.59	low_impact	-0.11	medium_impact	1.27	medium_impact	0.65	0.8	49.56	8.89	0.31	N	0.89	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14190	14190	C	G	MI.23186	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	484	162	V	L	Gtt/Ctt	2.69	0.01	0	benign	0.24	neutral	0.67	neutral	2.31	neutral	-2.68	neutral	-1.54	neutral_impact	0.42	0.79	neutral	0.73	neutral	2.55	19.77	deleterious	0.35	0.5	0.11	neutral	0.24	neutral	0.28	neutral	0.42	neutral	2	0.22	neutral	0.72	deleterious	-6	neutral	0.31	neutral	-0.34	medium_impact	0.38	medium_impact	-0.79	medium_impact	0.70	0.85	49.56	8.89	0.32	N	0.60	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14190	14190	C	A	MI.23187	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	484	162	V	F	Gtt/Ttt	2.69	0.01	0	possibly_damaging	0.85	neutral	0.71	neutral	2.13	deleterious	-4.72	deleterious	-3.44	medium_impact	2.19	0.87	neutral	0.68	neutral	3.30	22.90	deleterious	0.19	0.45	0.46	neutral	0.9	disease	0.58	disease	0.79	disease	6	0.82	neutral	0.43	neutral	0	NA	0.77	deleterious	-1.49	low_impact	0.42	medium_impact	0.7	medium_impact	0.77	0.85	49.56	8.89	0.28	N	0.79	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14190	14190	C	T	MI.23188	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	484	162	V	I	Gtt/Att	2.69	0.01	0	possibly_damaging	0.47	neutral	0.4	neutral	2.47	neutral	-2.26	neutral	-0.13	low_impact	0.88	0.84	neutral	0.98	neutral	1.55	13.58	neutral	0.43	0.55	0.1	neutral	0.33	neutral	0.34	neutral	0.43	neutral	1	0.57	neutral	0.47	neutral	-3	neutral	0.42	neutral	-0.75	medium_impact	0.11	medium_impact	-0.4	medium_impact	0.77	0.85	49.56	8.89	0.41	N	0.09	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14191	14191	A	T	MI.23189	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	483	161	F	L	ttT/ttA	-0.75	0	0	benign	0.04	neutral	1	neutral	2.7	neutral	-2.75	deleterious	-3.92	neutral_impact	0.57	0.91	neutral	0.98	neutral	0.73	9.00	deleterious	0.35	0.5	0.14	neutral	0.35	neutral	0.41	neutral	0.44	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.14	neutral	0.47	medium_impact	1.87	high_impact	-0.66	medium_impact	0.51	0.8	50.44	8.87	0.34	N	0.39	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6109	6109	T	C	MI.2319	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	206	69	M	T	aTa/aCa	7.07	1	0	benign	0.01	deleterious	0	neutral	2.78	neutral	-0.65	deleterious	-3.54	medium_impact	2.79	0.6	neutral	0.14	damaging	0.93	10.24	neutral	0.48	0.55	0.42	neutral	0.89	disease	0.58	disease	0.7	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.32	neutral	1.12	medium_impact	-1.48	low_impact	1.48	medium_impact	0.45	0.9	7.02	12.6	0.47	N	0.13	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14191	14191	A	C	MI.23190	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	483	161	F	L	ttT/ttG	-0.75	0	0	benign	0.04	neutral	1	neutral	2.7	neutral	-2.75	deleterious	-3.92	neutral_impact	0.57	0.91	neutral	0.98	neutral	0.65	8.48	deleterious	0.35	0.5	0.14	neutral	0.35	neutral	0.41	neutral	0.44	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.14	neutral	0.47	medium_impact	1.87	high_impact	-0.66	medium_impact	0.51	0.8	50.44	8.87	0.35	N	0.39	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14192	14192	A	T	MI.23191	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	482	161	F	Y	tTt/tAt	-0.29	0	0	possibly_damaging	0.78	neutral	0.98	neutral	2.21	deleterious	-3.12	deleterious	-2.58	medium_impact	2.74	0.74	neutral	0.58	neutral	3.86	23.50	deleterious	0.21	0.45	0.48	neutral	0.87	disease	0.69	disease	0.8	disease	6	0.77	neutral	0.6	deleterious	0	NA	0.73	deleterious	-1.3	low_impact	1.15	medium_impact	1.16	medium_impact	0.61	0.8	50.44	8.87	0.25	N	0.75	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14192	14192	A	C	MI.23192	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	482	161	F	C	tTt/tGt	-0.29	0	0	probably_damaging	0.97	neutral	0.18	neutral	2.19	deleterious	-6.52	deleterious	-6.53	medium_impact	3.44	0.74	neutral	0.46	neutral	3.84	23.40	deleterious	0.25	0.45	0.69	disease	0.92	disease	0.7	disease	0.82	disease	6	0.98	neutral	0.11	neutral	1	deleterious	0.84	deleterious	-2.18	low_impact	-0.16	medium_impact	1.74	medium_impact	0.42	0.8	50.44	8.87	0.35	N	0.88	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14192	14192	A	G	MI.23193	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	482	161	F	S	tTt/tCt	-0.29	0	0	probably_damaging	0.91	neutral	0.5	neutral	2.21	deleterious	-4.91	deleterious	-6.73	medium_impact	3.44	0.75	neutral	0.54	neutral	4.46	24.20	deleterious	0.27	0.45	0.57	disease	0.9	disease	0.68	disease	0.8	disease	6	0.9	neutral	0.3	neutral	1	deleterious	0.79	deleterious	-1.72	low_impact	0.21	medium_impact	1.74	medium_impact	0.51	0.8	50.44	8.87	0.32	N	0.96	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14193	14193	A	C	MI.23194	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	481	161	F	V	Ttt/Gtt	6.59	0.79	0	possibly_damaging	0.57	neutral	0.59	neutral	2.32	deleterious	-3.78	deleterious	-5.32	medium_impact	2.4	0.84	neutral	0.85	neutral	1.16	11.53	neutral	0.31	0.45	0.22	neutral	0.92	disease	0.64	disease	0.61	disease	2	0.51	neutral	0.51	deleterious	0	NA	0.56	deleterious	-0.91	medium_impact	0.29	medium_impact	0.87	medium_impact	0.62	0.8	50.44	8.87	0.38	N	0.91	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14193	14193	A	T	MI.23195	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	481	161	F	I	Ttt/Att	6.59	0.79	0	possibly_damaging	0.44	neutral	0.45	neutral	2.3	deleterious	-3.78	deleterious	-4.32	medium_impact	2.75	0.74	neutral	0.54	neutral	2.41	18.87	deleterious	0.25	0.45	0.14	neutral	0.86	disease	0.62	disease	0.75	disease	5	0.51	neutral	0.51	deleterious	0	NA	0.50	deleterious	-0.7	medium_impact	0.16	medium_impact	1.16	medium_impact	0.64	0.8	50.44	8.87	0.39	N	0.81	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14193	14193	A	G	MI.23196	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	481	161	F	L	Ttt/Ctt	6.59	0.79	0	benign	0.04	neutral	1	neutral	2.7	neutral	-2.75	deleterious	-3.92	neutral_impact	0.57	0.91	neutral	0.98	neutral	1.06	11.00	neutral	0.35	0.5	0.14	neutral	0.35	neutral	0.41	neutral	0.44	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.14	neutral	0.47	medium_impact	1.87	high_impact	-0.66	medium_impact	0.51	0.8	50.44	8.87	0.51	N	0.39	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14194	14194	C	A	MI.23197	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	480	160	L	F	ttG/ttT	-0.06	0	0	probably_damaging	1	neutral	0.71	neutral	0.41	deleterious	-6.98	deleterious	-3.92	high_impact	3.94	0.62	neutral	0.07	damaging	4.30	24.00	deleterious	0.32	0.5	0.54	disease	0.91	disease	0.76	disease	0.82	disease	6	1	deleterious	0.36	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.42	medium_impact	2.16	high_impact	0.63	0.8	50	8.83	0.37	N	0.80	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14194	14194	C	G	MI.23198	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	480	160	L	F	ttG/ttC	-0.06	0	0	probably_damaging	1	neutral	0.71	neutral	0.41	deleterious	-6.98	deleterious	-3.92	high_impact	3.94	0.62	neutral	0.07	damaging	3.84	23.40	deleterious	0.32	0.5	0.54	disease	0.91	disease	0.76	disease	0.82	disease	6	1	deleterious	0.36	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.42	medium_impact	2.16	high_impact	0.63	0.8	50	8.83	0.32	N	0.80	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14195	14195	A	C	MI.23199	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	479	160	L	W	tTg/tGg	-4.87	0	0	probably_damaging	1	neutral	0.19	neutral	0.38	deleterious	-10.42	deleterious	-5.88	high_impact	3.94	0.5	damaging	0.04	damaging	3.45	23.00	deleterious	0.13	0.4	0.9	disease	0.94	disease	0.78	disease	0.9	disease	8	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.14	medium_impact	2.16	high_impact	0.58	0.8	50	8.83	0.34	N	0.91	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8635	8635	C	A	MI.232	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	109	37	L	I	Ctc/Atc	-1.26	0	0	benign	0.39	neutral	0.27	neutral	4.33	neutral	-0.7	neutral	-1.42	low_impact	1.01	0.91	neutral	0.63	neutral	2.31	18.22	deleterious	0.39	0.65	0.49	neutral	0.32	neutral	0.51	disease	0.46	neutral	1	0.68	neutral	0.44	neutral	-6	neutral	0.41	neutral	-0.57	medium_impact	0.05	medium_impact	-0.23	medium_impact	0.66	0.9	20.35	20.89	0.41	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6109	6109	T	A	MI.2320	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	206	69	M	K	aTa/aAa	7.07	1	0	benign	0.17	deleterious	0	neutral	2.74	neutral	-1.97	deleterious	-3.67	high_impact	4.67	0.57	damaging	0.05	damaging	2.08	16.71	deleterious	0.25	0.55	0.61	disease	0.95	disease	0.7	disease	0.87	disease	7	1	deleterious	0.42	neutral	2	deleterious	0.43	neutral	-0.11	medium_impact	-1.48	low_impact	3.21	high_impact	0.53	0.9	7.02	12.6	0.56	P	0.80	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14195	14195	A	G	MI.23200	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	479	160	L	S	tTg/tCg	-4.87	0	0	probably_damaging	1	neutral	0.66	neutral	0.39	deleterious	-7.79	deleterious	-5.88	high_impact	3.6	0.47	damaging	0.04	damaging	3.82	23.40	deleterious	0.18	0.45	0.8	disease	0.93	disease	0.76	disease	0.87	disease	7	1	deleterious	0.33	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.37	medium_impact	1.88	medium_impact	0.55	0.8	50	8.83	0.38	N	0.91	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14196	14196	A	C	MI.23201	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	478	160	L	V	Ttg/Gtg	8.42	0.92	0	probably_damaging	1	neutral	0.61	neutral	0.42	deleterious	-6.46	deleterious	-2.92	high_impact	3.94	0.4	damaging	0.04	damaging	3.40	23.00	deleterious	0.28	0.45	0.38	neutral	0.89	disease	0.76	disease	0.8	disease	6	1	deleterious	0.31	neutral	2	deleterious	0.81	deleterious	-3.55	low_impact	0.31	medium_impact	2.16	high_impact	0.71	0.85	50	8.83	0.67	P	0.60	NA	NA	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14196	14196	A	T	MI.23202	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	478	160	L	M	Ttg/Atg	8.42	0.92	0	probably_damaging	1	neutral	0.26	neutral	0.44	deleterious	-5.97	neutral	-1.82	medium_impact	3.05	0.65	neutral	0.12	damaging	3.54	23.10	deleterious	0.25	0.45	0.49	neutral	0.81	disease	0.72	disease	0.74	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	-0.05	medium_impact	1.42	medium_impact	0.68	0.85	50	8.83	0.54	P	0.31	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14198	14198	G	T	MI.23203	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	476	159	T	K	aCa/aAa	-14.04	0	0	possibly_damaging	0.74	neutral	0.29	neutral	2.27	deleterious	-3.9	neutral	-1.48	medium_impact	2.16	0.78	neutral	0.56	neutral	4.07	23.70	deleterious	0.35	0.5	0.2	neutral	0.79	disease	0.56	disease	0.78	disease	6	0.8	neutral	0.28	neutral	0	NA	0.62	deleterious	-1.21	low_impact	-0.01	medium_impact	0.67	medium_impact	0.84	0.9	49.12	8.85	0.34	N	0.75	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14198	14198	G	A	MI.23204	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	476	159	T	M	aCa/aTa	-14.04	0	0	probably_damaging	0.98	neutral	0.23	neutral	2.31	deleterious	-5.2	neutral	-1.84	low_impact	1.12	0.89	neutral	0.93	neutral	2.76	21.20	deleterious	0.48	0.55	0.32	neutral	0.43	neutral	0.31	neutral	0.48	neutral	0	0.98	deleterious	0.13	neutral	-2	neutral	0.68	deleterious	-2.35	low_impact	-0.09	medium_impact	-0.2	medium_impact	0.89	0.9	49.12	8.85	0.51	N	0.78	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14199	14199	T	G	MI.23205	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	475	159	T	P	Aca/Cca	0.4	0	0	probably_damaging	0.9	neutral	0.17	neutral	2.27	deleterious	-4.83	neutral	-2.29	medium_impact	2.16	0.83	neutral	0.47	neutral	3.85	23.40	deleterious	0.2	0.45	0.31	neutral	0.89	disease	0.57	disease	0.82	disease	6	0.95	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-1.67	low_impact	-0.18	medium_impact	0.67	medium_impact	0.72	0.85	49.12	8.85	0.36	N	0.82	NA	NA	0.53	rs2857288	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14199	14199	T	C	MI.23206	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	475	159	T	A	Aca/Gca	0.4	0	0	benign	0.05	neutral	0.42	neutral	2.34	neutral	-2.73	neutral	-0.24	neutral_impact	-0.4	0.93	neutral	0.93	neutral	2.07	16.69	deleterious	0.69	0.75	0.15	neutral	0.4	neutral	0.29	neutral	0.44	neutral	1	0.54	neutral	0.69	deleterious	-6	neutral	0.15	neutral	0.38	medium_impact	0.13	medium_impact	-1.48	low_impact	0.76	0.85	49.12	8.85	0.41	N	0.43	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14199	14199	T	A	MI.23207	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	475	159	T	S	Aca/Tca	0.4	0	0	benign	0.16	neutral	0.3	neutral	2.3	deleterious	-3.04	neutral	1.86	neutral_impact	-0.5	0.86	neutral	0.98	neutral	0.97	10.49	neutral	0.46	0.55	0.11	neutral	0.31	neutral	0.23	neutral	0.44	neutral	1	0.65	neutral	0.57	deleterious	-6	neutral	0.18	neutral	-0.14	medium_impact	0	medium_impact	-1.56	low_impact	0.70	0.85	49.12	8.85	0.48	N	0.16	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14200	14200	T	A	MI.23208	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	474	158	W	C	tgA/tgT	-0.29	0	0.07	probably_damaging	1	neutral	0.13	neutral	2.3	deleterious	-8.07	deleterious	-12.96	high_impact	3.96	0.68	neutral	0.05	damaging	4.60	24.40	deleterious	0.27	0.45	0.93	disease	0.97	disease	0.85	disease	0.88	disease	8	1	deleterious	0.07	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	-0.25	medium_impact	2.18	high_impact	0.28	0.8	48.67	8.64	0.45	N	0.96	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14200	14200	T	G	MI.23209	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	474	158	W	C	tgA/tgC	-0.29	0	0.07	probably_damaging	1	neutral	0.13	neutral	2.3	deleterious	-8.07	deleterious	-12.96	high_impact	3.96	0.68	neutral	0.05	damaging	4.46	24.20	deleterious	0.27	0.45	0.93	disease	0.97	disease	0.85	disease	0.88	disease	8	1	deleterious	0.07	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	-0.25	medium_impact	2.18	high_impact	0.28	0.8	48.67	8.64	0.42	N	0.96	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6110	6110	A	T	MI.2321	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	207	69	M	I	atA/atT	5.91	1	0	benign	0.17	deleterious	0	neutral	2.84	neutral	0.47	neutral	-2.17	high_impact	4.12	0.51	damaging	0.08	damaging	1.65	14.13	neutral	0.51	0.6	0.33	neutral	0.94	disease	0.62	disease	0.8	disease	6	1	deleterious	0.42	neutral	2	deleterious	0.35	neutral	-0.11	medium_impact	-1.48	low_impact	2.71	high_impact	0.58	0.9	7.02	12.6	0.5	P	0.56	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14201	14201	C	G	MI.23210	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	473	158	W	S	tGa/tCa	-3.73	0	0	probably_damaging	1	neutral	0.44	neutral	2.33	deleterious	-6.51	deleterious	-13.96	high_impact	3.96	0.67	neutral	0.08	damaging	4.40	24.10	deleterious	0.24	0.45	0.87	disease	0.98	disease	0.83	disease	0.89	disease	8	1	deleterious	0.22	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.15	medium_impact	2.18	high_impact	0.21	0.8	48.67	8.64	0.46	N	0.92	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14201	14201	C	A	MI.23211	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	473	158	W	L	tGa/tTa	-3.73	0	0	probably_damaging	1	neutral	0.73	neutral	2.59	deleterious	-5.31	deleterious	-12.96	medium_impact	3.26	0.76	neutral	0.07	damaging	4.80	24.80	deleterious	0.27	0.45	0.76	disease	0.96	disease	0.82	disease	0.91	disease	8	1	deleterious	0.37	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	0.45	medium_impact	1.59	medium_impact	0.28	0.8	48.67	8.64	0.38	N	0.95	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14202	14202	A	C	MI.23212	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	472	158	W	G	Tga/Gga	2.69	0.98	0	probably_damaging	1	neutral	0.45	neutral	2.32	deleterious	-6.55	deleterious	-12.96	medium_impact	2.98	0.74	neutral	0.13	damaging	3.73	23.30	deleterious	0.25	0.45	0.83	disease	0.96	disease	0.84	disease	0.88	disease	8	1	deleterious	0.23	neutral	1	deleterious	0.87	deleterious	-3.55	low_impact	0.16	medium_impact	1.36	medium_impact	0.28	0.8	48.67	8.64	0.49	N	0.90	NA	NA	0.62	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14202	14202	A	G	MI.23213	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	472	158	W	R	Tga/Cga	2.69	0.98	0	probably_damaging	1	neutral	0.26	neutral	2.3	deleterious	-6.64	deleterious	-13.96	high_impact	3.96	0.68	neutral	0.05	damaging	3.80	23.40	deleterious	0.28	0.45	0.87	disease	0.97	disease	0.87	disease	0.9	disease	8	1	deleterious	0.13	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.05	medium_impact	2.18	high_impact	0.31	0.8	48.67	8.64	0.58	P	0.96	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14204	14204	C	T	MI.23214	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	470	157	G	D	gGt/gAt	-7.17	0	0	probably_damaging	0.99	neutral	0.11	neutral	2.13	deleterious	-5.45	deleterious	-6.75	medium_impact	3.33	0.73	neutral	0.21	damaging	4.16	23.80	deleterious	0.17	0.45	0.53	disease	0.96	disease	0.83	disease	0.93	disease	9	1	deleterious	0.06	neutral	1	deleterious	0.86	deleterious	-2.63	low_impact	-0.3	medium_impact	1.65	medium_impact	0.70	0.85	48.67	9	0.35	N	0.96	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14204	14204	C	A	MI.23215	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	470	157	G	V	gGt/gTt	-7.17	0	0	probably_damaging	0.96	neutral	1	neutral	2.26	deleterious	-5.73	deleterious	-8.61	medium_impact	2.63	0.78	neutral	0.36	neutral	4.43	24.20	deleterious	0.3	0.45	0.39	neutral	0.96	disease	0.74	disease	0.85	disease	7	0.96	neutral	0.52	deleterious	1	deleterious	0.84	deleterious	-2.06	low_impact	1.87	high_impact	1.06	medium_impact	0.80	0.85	48.67	9	0.33	N	0.98	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14204	14204	C	G	MI.23216	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	470	157	G	A	gGt/gCt	-7.17	0	0	possibly_damaging	0.8	neutral	0.24	neutral	2.41	deleterious	-4.4	deleterious	-5.68	low_impact	1.87	0.75	neutral	0.56	neutral	3.43	23.00	deleterious	0.47	0.55	0.16	neutral	0.73	disease	0.59	disease	0.55	disease	1	0.87	neutral	0.22	neutral	-3	neutral	0.70	deleterious	-1.35	low_impact	-0.07	medium_impact	0.43	medium_impact	0.91	0.95	48.67	9	0.36	N	0.78	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14205	14205	C	A	MI.23217	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	469	157	G	C	Ggt/Tgt	2	0.46	0	benign	0.24	neutral	0.06	neutral	2.17	deleterious	-7.01	deleterious	-8.27	low_impact	1.9	0.79	neutral	0.21	damaging	4.69	24.60	deleterious	0.22	0.45	0.67	disease	0.97	disease	0.73	disease	0.85	disease	7	0.93	neutral	0.41	neutral	-6	neutral	0.47	deleterious	-0.34	medium_impact	-0.46	medium_impact	0.45	medium_impact	0.84	0.9	48.67	9	0.39	N	0.97	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14205	14205	C	T	MI.23218	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	469	157	G	S	Ggt/Agt	2	0.46	0	probably_damaging	0.96	neutral	0.16	neutral	2.33	deleterious	-4.66	deleterious	-5.72	high_impact	3.67	0.72	neutral	0.3	neutral	4.51	24.30	deleterious	0.4	0.5	0.32	neutral	0.94	disease	0.76	disease	0.87	disease	7	0.98	neutral	0.1	neutral	2	deleterious	0.81	deleterious	-2.06	low_impact	-0.19	medium_impact	1.93	medium_impact	0.96	1	48.67	9	0.48	N	1.00	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14205	14205	C	G	MI.23219	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	469	157	G	R	Ggt/Cgt	2	0.46	0	probably_damaging	0.99	neutral	0.15	neutral	2.13	deleterious	-5.95	deleterious	-7.71	high_impact	3.67	0.74	neutral	0.17	damaging	4.30	24.00	deleterious	0.16	0.45	0.49	neutral	0.97	disease	0.84	disease	0.94	disease	9	0.99	deleterious	0.08	neutral	2	deleterious	0.88	deleterious	-2.63	low_impact	-0.21	medium_impact	1.93	medium_impact	0.87	0.9	48.67	9	0.51	N	1.00	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6110	6110	A	C	MI.2322	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	207	69	M	I	atA/atC	5.91	1	0	benign	0.17	deleterious	0	neutral	2.84	neutral	0.47	neutral	-2.17	high_impact	4.12	0.51	damaging	0.08	damaging	1.46	13.13	neutral	0.51	0.6	0.33	neutral	0.94	disease	0.62	disease	0.8	disease	6	1	deleterious	0.42	neutral	2	deleterious	0.35	neutral	-0.11	medium_impact	-1.48	low_impact	2.71	high_impact	0.58	0.9	7.02	12.6	0.5	P	0.56	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14207	14207	G	C	MI.23220	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	467	156	T	S	aCt/aGt	-3.73	0	0	benign	0.37	neutral	0.21	neutral	2.29	deleterious	-3.04	neutral	-1	neutral_impact	0.34	0.89	neutral	0.98	neutral	-0.40	0.38	neutral	0.47	0.55	0.24	neutral	0.34	neutral	0.32	neutral	0.44	neutral	1	0.75	neutral	0.42	neutral	-6	neutral	0.33	neutral	-0.58	medium_impact	-0.11	medium_impact	-0.86	medium_impact	0.74	0.85	50	8.71	0.59	P	0.47	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14207	14207	G	T	MI.23221	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	467	156	T	N	aCt/aAt	-3.73	0	0	possibly_damaging	0.82	neutral	0.23	neutral	2.25	deleterious	-4.26	deleterious	-3.12	medium_impact	2.35	0.76	neutral	0.52	neutral	3.11	22.50	deleterious	0.44	0.55	0.37	neutral	0.85	disease	0.55	disease	0.81	disease	6	0.88	neutral	0.21	neutral	0	NA	0.73	deleterious	-1.4	low_impact	-0.09	medium_impact	0.83	medium_impact	0.85	0.9	50	8.71	0.45	N	0.71	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14207	14207	G	A	MI.23222	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	467	156	T	I	aCt/aTt	-3.73	0	0	benign	0.36	neutral	0.49	neutral	2.36	deleterious	-3.86	deleterious	-3.26	medium_impact	2.35	0.77	neutral	0.48	neutral	1.98	16.09	deleterious	0.45	0.55	0.27	neutral	0.78	disease	0.53	disease	0.75	disease	5	0.43	neutral	0.57	deleterious	-3	neutral	0.39	neutral	-0.57	medium_impact	0.2	medium_impact	0.83	medium_impact	0.84	0.9	50	8.71	0.36	N	0.67	NA	NA	0.54	rs879217937	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14208	14208	T	C	MI.23223	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	466	156	T	A	Act/Gct	0.63	0	0	benign	0.02	neutral	0.34	neutral	2.42	neutral	-2.73	neutral	-0.14	neutral_impact	-0.14	0.95	neutral	0.99	neutral	-1.19	0.01	neutral	0.64	0.7	0.13	neutral	0.46	neutral	0.37	neutral	0.43	neutral	1	0.65	neutral	0.66	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	0.05	medium_impact	-1.26	low_impact	0.73	0.85	50	8.71	0.49	N	0.15	NA	NA	0.16	.	.	.	.	.	.	COSM1138249	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14208	14208	T	G	MI.23224	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	466	156	T	P	Act/Cct	0.63	0	0	possibly_damaging	0.76	neutral	0.1	neutral	2.25	deleterious	-4.83	deleterious	-3.19	medium_impact	2.69	0.77	neutral	0.38	neutral	3.61	23.20	deleterious	0.2	0.45	0.48	neutral	0.93	disease	0.55	disease	0.83	disease	6	0.93	neutral	0.17	neutral	0	NA	0.78	deleterious	-1.26	low_impact	-0.32	medium_impact	1.11	medium_impact	0.77	0.85	50	8.71	0.41	N	0.81	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14208	14208	T	A	MI.23225	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	466	156	T	S	Act/Tct	0.63	0	0	benign	0.37	neutral	0.21	neutral	2.29	deleterious	-3.04	neutral	-1	neutral_impact	0.34	0.89	neutral	0.98	neutral	0.04	2.93	deleterious	0.47	0.55	0.24	neutral	0.34	neutral	0.32	neutral	0.44	neutral	1	0.75	neutral	0.42	neutral	-6	neutral	0.33	neutral	-0.58	medium_impact	-0.11	medium_impact	-0.86	medium_impact	0.74	0.85	50	8.71	0.57	P	0.47	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14210	14210	A	C	MI.23226	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	464	155	V	G	gTt/gGt	-9	0	0	probably_damaging	1	neutral	0.14	neutral	2.19	deleterious	-5.02	deleterious	-6.4	medium_impact	2.88	0.76	neutral	0.5	neutral	3.60	23.20	deleterious	0.18	0.45	0.82	disease	0.9	disease	0.73	disease	0.83	disease	7	1	deleterious	0.07	neutral	1	deleterious	0.86	deleterious	-3.55	low_impact	-0.23	medium_impact	1.27	medium_impact	0.70	0.85	44.25	8.13	0.32	N	0.86	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14210	14210	A	G	MI.23227	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	464	155	V	A	gTt/gCt	-9	0	0	probably_damaging	1	neutral	0.26	neutral	2.26	deleterious	-3.61	deleterious	-3.6	medium_impact	2.23	0.86	neutral	0.74	neutral	3.68	23.30	deleterious	0.26	0.45	0.53	disease	0.83	disease	0.61	disease	0.62	disease	2	1	deleterious	0.13	neutral	1	deleterious	0.81	deleterious	-3.55	low_impact	-0.05	medium_impact	0.73	medium_impact	0.64	0.8	44.25	8.13	0.33	N	0.70	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14210	14210	A	T	MI.23228	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	464	155	V	D	gTt/gAt	-9	0	0	probably_damaging	1	neutral	0.06	neutral	2.18	deleterious	-5.67	deleterious	-6.33	medium_impact	3.44	0.77	neutral	0.4	neutral	4.25	23.90	deleterious	0.09	0.35	0.87	disease	0.94	disease	0.8	disease	0.92	disease	8	1	deleterious	0.03	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	-0.46	medium_impact	1.74	medium_impact	0.78	0.85	44.25	8.13	0.45	N	0.94	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14211	14211	C	T	MI.23229	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	463	155	V	I	Gtt/Att	4.29	0.18	0	probably_damaging	1	neutral	0.59	neutral	2.38	neutral	-2.26	neutral	-0.66	low_impact	0.85	0.8	neutral	0.93	neutral	0.88	9.94	deleterious	0.36	0.5	0.19	neutral	0.23	neutral	0.39	neutral	0.43	neutral	2	1	deleterious	0.3	neutral	-2	neutral	0.67	deleterious	-3.55	low_impact	0.29	medium_impact	-0.43	medium_impact	0.85	0.9	44.25	8.13	0.36	N	0.41	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6111	6111	G	C	MI.2323	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	208	70	V	L	Gta/Cta	0.13	0.95	0	probably_damaging	0.99	neutral	0.06	neutral	2.78	neutral	-0.18	neutral	-1.9	medium_impact	3.25	0.58	damaging	0.54	neutral	3.39	23.00	deleterious	0.4	0.55	0.38	neutral	0.68	disease	0.5	neutral	0.49	neutral	0	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-2.64	low_impact	-0.47	medium_impact	1.9	medium_impact	0.46	0.9	2.14	6.63	0.48	N	0.55	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14211	14211	C	A	MI.23230	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	463	155	V	F	Gtt/Ttt	4.29	0.18	0	probably_damaging	1	neutral	0.53	neutral	2.32	deleterious	-4.72	deleterious	-4.07	medium_impact	2.05	0.85	neutral	0.71	neutral	4.36	24.10	deleterious	0.21	0.45	0.62	disease	0.91	disease	0.51	disease	0.61	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.84	deleterious	-3.55	low_impact	0.24	medium_impact	0.58	medium_impact	0.80	0.85	44.25	8.13	0.33	N	0.93	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14211	14211	C	G	MI.23231	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	463	155	V	L	Gtt/Ctt	4.29	0.18	0	probably_damaging	1	neutral	1	neutral	2.73	neutral	-2.68	neutral	-2.07	low_impact	1.38	0.84	neutral	0.93	neutral	2.37	18.65	deleterious	0.36	0.5	0.22	neutral	0.68	disease	0.41	neutral	0.52	disease	0	1	deleterious	0.5	deleterious	-2	neutral	0.73	deleterious	-3.55	low_impact	1.87	high_impact	0.02	medium_impact	0.78	0.85	44.25	8.13	0.32	N	0.62	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14213	14213	A	T	MI.23232	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	461	154	V	E	gTa/gAa	-6.02	0	0	probably_damaging	0.97	neutral	0.11	neutral	2.29	deleterious	-5.19	deleterious	-4.68	medium_impact	2.98	0.77	neutral	0.39	neutral	4.42	24.20	deleterious	0.1	0.4	0.79	disease	0.94	disease	0.75	disease	0.89	disease	8	0.99	deleterious	0.07	neutral	1	deleterious	0.86	deleterious	-2.18	low_impact	-0.3	medium_impact	1.36	medium_impact	0.70	0.85	15.49	11.76	0.3	N	0.92	NA	NA	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14213	14213	A	C	MI.23233	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	461	154	V	G	gTa/gGa	-6.02	0	0	probably_damaging	0.97	neutral	0.17	neutral	2.19	deleterious	-5.02	deleterious	-5.11	medium_impact	2.52	0.8	neutral	0.54	neutral	3.50	23.10	deleterious	0.14	0.4	0.79	disease	0.87	disease	0.66	disease	0.76	disease	5	0.98	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-2.18	low_impact	-0.18	medium_impact	0.97	medium_impact	0.75	0.85	15.49	11.76	0.28	N	0.88	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14213	14213	A	G	MI.23234	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	461	154	V	A	gTa/gCa	-6.02	0	0	possibly_damaging	0.8	neutral	0.36	neutral	2.23	deleterious	-3.61	deleterious	-2.64	medium_impact	2.08	0.88	neutral	0.93	neutral	2.44	19.11	deleterious	0.26	0.45	0.49	neutral	0.78	disease	0.55	disease	0.59	disease	2	0.81	neutral	0.28	neutral	0	NA	0.70	deleterious	-1.35	low_impact	0.07	medium_impact	0.6	medium_impact	0.70	0.85	15.49	11.76	0.29	N	0.48	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14214	14214	C	T	MI.23235	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	460	154	V	M	Gta/Ata	1.77	0	0	probably_damaging	0.95	neutral	0.15	neutral	2.26	deleterious	-4.64	neutral	-1.66	low_impact	1.88	0.86	neutral	0.72	neutral	1.40	12.78	neutral	0.32	0.5	0.51	disease	0.55	disease	0.36	neutral	0.51	disease	0	0.97	neutral	0.1	neutral	-2	neutral	0.71	deleterious	-1.97	low_impact	-0.21	medium_impact	0.44	medium_impact	0.81	0.85	15.49	11.76	0.4	N	0.68	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14214	14214	C	G	MI.23236	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	460	154	V	L	Gta/Cta	1.77	0	0	benign	0.05	neutral	0.9	neutral	2.4	neutral	-2.68	neutral	-1.38	neutral_impact	0.52	0.9	neutral	0.9	neutral	0.94	10.29	neutral	0.34	0.5	0.16	neutral	0.53	disease	0.29	neutral	0.43	neutral	1	0.03	neutral	0.93	deleterious	-6	neutral	0.18	neutral	0.38	medium_impact	0.74	medium_impact	-0.7	medium_impact	0.77	0.85	15.49	11.76	0.29	N	0.67	NA	NA	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14214	14214	C	A	MI.23237	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	460	154	V	L	Gta/Tta	1.77	0	0	benign	0.05	neutral	0.9	neutral	2.4	neutral	-2.68	neutral	-1.38	neutral_impact	0.52	0.9	neutral	0.9	neutral	1.18	11.65	neutral	0.34	0.5	0.16	neutral	0.53	disease	0.29	neutral	0.43	neutral	1	0.03	neutral	0.93	deleterious	-6	neutral	0.18	neutral	0.38	medium_impact	0.74	medium_impact	-0.7	medium_impact	0.77	0.85	15.49	11.76	0.29	N	0.67	NA	NA	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14216	14216	A	C	MI.23238	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	458	153	V	G	gTa/gGa	-3.73	0	0	probably_damaging	0.91	neutral	0.18	neutral	2.15	deleterious	-3.71	deleterious	-5.64	medium_impact	3.08	0.71	neutral	0.5	neutral	3.59	23.20	deleterious	0.14	0.4	0.67	disease	0.89	disease	0.61	disease	0.82	disease	6	0.95	neutral	0.14	neutral	1	deleterious	0.81	deleterious	-1.72	low_impact	-0.16	medium_impact	1.44	medium_impact	0.70	0.85	49.56	8.78	0.31	N	0.90	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14216	14216	A	T	MI.23239	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	458	153	V	E	gTa/gAa	-3.73	0	0	probably_damaging	0.97	neutral	0.07	neutral	2.15	deleterious	-3.41	deleterious	-4.68	medium_impact	3.08	0.73	neutral	0.45	neutral	4.44	24.20	deleterious	0.1	0.4	0.68	disease	0.94	disease	0.72	disease	0.89	disease	8	0.99	deleterious	0.05	neutral	1	deleterious	0.86	deleterious	-2.18	low_impact	-0.42	medium_impact	1.44	medium_impact	0.65	0.8	49.56	8.78	0.32	N	0.90	NA	NA	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6111	6111	G	T	MI.2324	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	208	70	V	L	Gta/Tta	0.13	0.95	0	probably_damaging	0.99	neutral	0.06	neutral	2.78	neutral	-0.18	neutral	-1.9	medium_impact	3.25	0.58	damaging	0.54	neutral	3.54	23.10	deleterious	0.4	0.55	0.38	neutral	0.68	disease	0.5	neutral	0.49	neutral	0	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-2.64	low_impact	-0.47	medium_impact	1.9	medium_impact	0.46	0.9	2.14	6.63	0.48	N	0.55	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14216	14216	A	G	MI.23240	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	458	153	V	A	gTa/gCa	-3.73	0	0	benign	0.23	neutral	0.22	neutral	2.2	neutral	-1.88	deleterious	-2.94	medium_impact	3.08	0.72	neutral	0.63	neutral	3.74	23.30	deleterious	0.31	0.45	0.39	neutral	0.79	disease	0.58	disease	0.78	disease	6	0.74	neutral	0.5	deleterious	-3	neutral	0.47	deleterious	-0.32	medium_impact	-0.1	medium_impact	1.44	medium_impact	0.71	0.85	49.56	8.78	0.4	N	0.65	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14217	14217	C	G	MI.23241	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	457	153	V	L	Gta/Cta	8.19	0.96	0	possibly_damaging	0.78	neutral	1	neutral	2.46	neutral	2.02	neutral	-0.78	neutral_impact	0.16	0.83	neutral	0.93	neutral	2.09	16.81	deleterious	0.25	0.45	0.11	neutral	0.3	neutral	0.31	neutral	0.43	neutral	2	0.78	neutral	0.61	deleterious	-3	neutral	0.61	deleterious	-1.3	low_impact	1.87	high_impact	-1.01	low_impact	0.72	0.85	49.56	8.78	0.52	N	0.36	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14217	14217	C	T	MI.23242	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	457	153	V	M	Gta/Ata	8.19	0.96	0	probably_damaging	0.99	neutral	0.1	neutral	2.21	neutral	-0.01	neutral	-0.18	low_impact	0.9	0.87	neutral	0.77	neutral	1.52	13.40	neutral	0.33	0.5	0.23	neutral	0.63	disease	0.3	neutral	0.46	neutral	1	1	deleterious	0.06	neutral	-2	neutral	0.70	deleterious	-2.63	low_impact	-0.32	medium_impact	-0.39	medium_impact	0.81	0.85	49.56	8.78	0.53	P	0.33	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14217	14217	C	A	MI.23243	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	457	153	V	L	Gta/Tta	8.19	0.96	0	possibly_damaging	0.78	neutral	1	neutral	2.46	neutral	2.02	neutral	-0.78	neutral_impact	0.16	0.83	neutral	0.93	neutral	2.34	18.42	deleterious	0.25	0.45	0.11	neutral	0.3	neutral	0.31	neutral	0.43	neutral	2	0.78	neutral	0.61	deleterious	-3	neutral	0.61	deleterious	-1.3	low_impact	1.87	high_impact	-1.01	low_impact	0.72	0.85	49.56	8.78	0.52	N	0.36	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14218	14218	T	A	MI.23244	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	456	152	L	F	ttA/ttT	-1.44	0	0.01	probably_damaging	0.96	neutral	0.26	neutral	2.17	deleterious	-4.41	neutral	-1.62	low_impact	1.25	0.91	neutral	0.92	neutral	2.78	21.20	deleterious	0.37	0.5	0.47	neutral	0.7	disease	0.37	neutral	0.57	disease	1	0.97	neutral	0.15	neutral	-2	neutral	0.76	deleterious	-2.06	low_impact	-0.05	medium_impact	-0.09	medium_impact	0.73	0.85	46.9	8.18	0.4	N	0.65	NA	NA	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14219	14219	A	G	MI.23245	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	455	152	L	S	tTa/tCa	-5.1	0	0	probably_damaging	0.96	neutral	0.09	neutral	2.17	deleterious	-5.22	deleterious	-4.53	medium_impact	2.46	0.74	neutral	0.5	neutral	3.98	23.60	deleterious	0.21	0.45	0.67	disease	0.85	disease	0.65	disease	0.79	disease	6	0.99	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-2.06	low_impact	-0.35	medium_impact	0.92	medium_impact	0.79	0.85	46.9	8.18	0.32	N	0.84	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14219	14219	A	C	MI.23246	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	455	152	L	W	tTa/tGa	-5.1	0	0	probably_damaging	0.99	neutral	0.16	neutral	2.16	deleterious	-7.24	deleterious	-4.07	medium_impact	2.72	0.83	neutral	0.43	neutral	3.57	23.10	deleterious	0.13	0.4	0.85	disease	0.92	disease	0.68	disease	0.82	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.87	deleterious	-2.63	low_impact	-0.19	medium_impact	1.14	medium_impact	0.70	0.85	46.9	8.18	0.34	N	0.89	NA	NA	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14220	14220	A	T	MI.23247	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	454	152	L	M	Tta/Ata	2.46	0	0	probably_damaging	0.97	neutral	0.14	neutral	2.23	deleterious	-4.39	neutral	-0.77	low_impact	1.18	0.86	neutral	0.97	neutral	2.25	17.83	deleterious	0.27	0.45	0.21	neutral	0.1	neutral	0.24	neutral	0.26	neutral	5	0.99	deleterious	0.09	neutral	-2	neutral	0.66	deleterious	-2.18	low_impact	-0.23	medium_impact	-0.15	medium_impact	0.80	0.85	46.9	8.18	0.51	N	0.24	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14220	14220	A	C	MI.23248	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	454	152	L	V	Tta/Gta	2.46	0	0	benign	0.15	neutral	0.35	neutral	2.29	deleterious	-3.31	neutral	-1.75	low_impact	0.87	0.94	neutral	0.95	neutral	2.12	16.96	deleterious	0.31	0.5	0.16	neutral	0.65	disease	0.35	neutral	0.46	neutral	1	0.59	neutral	0.6	deleterious	-6	neutral	0.24	neutral	-0.11	medium_impact	0.06	medium_impact	-0.41	medium_impact	0.80	0.85	46.9	8.18	0.45	N	0.53	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14221	14221	T	G	MI.23249	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	453	151	W	C	tgA/tgC	-4.64	0	0	probably_damaging	1	deleterious	0.03	neutral	2.31	deleterious	-7.1	deleterious	-12.87	medium_impact	2.98	0.72	neutral	0.06	damaging	4.43	24.20	deleterious	0.42	0.55	0.71	disease	0.9	disease	0.74	disease	0.81	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.88	deleterious	-3.55	low_impact	-0.63	medium_impact	1.36	medium_impact	0.36	0.8	50.44	8.78	0.32	N	0.96	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6111	6111	G	A	MI.2325	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	208	70	V	M	Gta/Ata	0.13	0.95	0	probably_damaging	1	deleterious	0	neutral	2.6	neutral	-1.96	neutral	-1.9	high_impact	4.64	0.63	neutral	0.59	neutral	3.59	23.20	deleterious	0.39	0.55	0.63	disease	0.71	disease	0.6	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.19	high_impact	0.74	0.9	2.14	6.63	0.59	P	0.82	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14221	14221	T	A	MI.23250	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	453	151	W	C	tgA/tgT	-4.64	0	0	probably_damaging	1	deleterious	0.03	neutral	2.31	deleterious	-7.1	deleterious	-12.87	medium_impact	2.98	0.72	neutral	0.06	damaging	4.70	24.60	deleterious	0.42	0.55	0.71	disease	0.9	disease	0.74	disease	0.81	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.88	deleterious	-3.55	low_impact	-0.63	medium_impact	1.36	medium_impact	0.36	0.8	50.44	8.78	0.31	N	0.96	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14222	14222	C	A	MI.23251	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	452	151	W	L	tGa/tTa	-4.19	0	0	probably_damaging	1	neutral	1	neutral	2.51	deleterious	-4.25	deleterious	-12.87	medium_impact	2.25	0.77	neutral	0.13	damaging	4.91	24.90	deleterious	0.34	0.5	0.36	neutral	0.8	disease	0.72	disease	0.63	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.80	deleterious	-3.55	low_impact	1.87	high_impact	0.75	medium_impact	0.38	0.8	50.44	8.78	0.23	N	0.95	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14222	14222	C	G	MI.23252	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	452	151	W	S	tGa/tCa	-4.19	0	0	probably_damaging	1	neutral	0.1	neutral	2.38	deleterious	-5.45	deleterious	-13.82	medium_impact	2.87	0.72	neutral	0.15	damaging	4.32	24.00	deleterious	0.31	0.5	0.35	neutral	0.86	disease	0.75	disease	0.78	disease	6	1	deleterious	0.05	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	-0.32	medium_impact	1.26	medium_impact	0.46	0.8	50.44	8.78	0.43	N	0.92	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14223	14223	A	G	MI.23253	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	451	151	W	R	Tga/Cga	0.63	0	0	probably_damaging	1	neutral	0.06	neutral	2.31	deleterious	-5.59	deleterious	-13.86	high_impact	3.67	0.74	neutral	0.05	damaging	3.83	23.40	deleterious	0.41	0.5	0.35	neutral	0.89	disease	0.81	disease	0.83	disease	7	1	deleterious	0.03	neutral	2	deleterious	0.82	deleterious	-3.55	low_impact	-0.46	medium_impact	1.93	medium_impact	0.42	0.8	50.44	8.78	0.44	N	0.96	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14223	14223	A	C	MI.23254	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	451	151	W	G	Tga/Gga	0.63	0	0	probably_damaging	1	neutral	0.12	neutral	2.33	deleterious	-5.63	deleterious	-12.86	low_impact	1.73	0.77	neutral	0.27	damaging	3.73	23.30	deleterious	0.29	0.45	0.19	neutral	0.36	neutral	0.71	disease	0.48	neutral	0	1	deleterious	0.06	neutral	-2	neutral	0.70	deleterious	-3.55	low_impact	-0.27	medium_impact	0.31	medium_impact	0.57	0.8	50.44	8.78	0.36	N	0.90	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14225	14225	C	T	MI.23255	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	449	150	R	H	cGt/cAt	-1.89	0	0	possibly_damaging	0.8	neutral	0.44	neutral	2.31	deleterious	-5.32	neutral	0.02	low_impact	1.79	0.77	neutral	0.39	neutral	2.82	21.50	deleterious	0.58	0.65	0.31	neutral	0.5	neutral	0.38	neutral	0.51	disease	0	0.8	neutral	0.32	neutral	-3	neutral	0.62	deleterious	-1.35	low_impact	0.15	medium_impact	0.36	medium_impact	0.98	1	15.93	11.92	0.39	N	0.55	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14225	14225	C	A	MI.23256	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	449	150	R	L	cGt/cTt	-1.89	0	0	benign	0.14	neutral	1	neutral	2.45	deleterious	-4.56	neutral	-0.2	low_impact	1.45	0.82	neutral	0.42	neutral	1.17	11.60	neutral	0.44	0.55	0.16	neutral	0.8	disease	0.5	neutral	0.71	disease	4	0.14	neutral	0.93	deleterious	-6	neutral	0.26	neutral	-0.07	medium_impact	1.87	high_impact	0.08	medium_impact	0.58	0.8	15.93	11.92	0.24	N	0.78	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14225	14225	C	G	MI.23257	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	449	150	R	P	cGt/cCt	-1.89	0	0	possibly_damaging	0.75	neutral	0.18	neutral	2.47	deleterious	-5.6	neutral	-0.55	low_impact	1.79	0.74	neutral	0.3	neutral	3.14	22.60	deleterious	0.25	0.45	0.34	neutral	0.91	disease	0.66	disease	0.82	disease	6	0.87	neutral	0.22	neutral	-3	neutral	0.71	deleterious	-1.23	low_impact	-0.16	medium_impact	0.36	medium_impact	0.68	0.85	15.93	11.92	0.39	N	0.83	NA	NA	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14226	14226	G	T	MI.23258	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	448	150	R	S	Cgt/Agt	-2.81	0	0.01	benign	0.34	neutral	0.37	neutral	2.45	deleterious	-4.29	neutral	2	neutral_impact	0.24	0.88	neutral	0.87	neutral	0.80	9.48	deleterious	0.34	0.5	0.16	neutral	0.53	disease	0.37	neutral	0.44	neutral	1	0.56	neutral	0.52	deleterious	-6	neutral	0.33	neutral	-0.53	medium_impact	0.08	medium_impact	-0.94	medium_impact	0.72	0.85	15.93	11.92	0.39	N	0.56	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14226	14226	G	A	MI.23259	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	448	150	R	C	Cgt/Tgt	-2.81	0	0.01	benign	0.01	neutral	0.16	neutral	2.31	deleterious	-6.86	neutral	1.15	neutral_impact	0.24	0.9	neutral	0.7	neutral	1.63	14.04	neutral	0.43	0.55	0.47	neutral	0.82	disease	0.3	neutral	0.59	disease	2	0.84	neutral	0.58	deleterious	-6	neutral	0.26	neutral	1.03	medium_impact	-0.19	medium_impact	-0.94	medium_impact	0.97	1	15.93	11.92	0.42	N	0.62	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6112	6112	T	A	MI.2326	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	209	70	V	E	gTa/gAa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.01	deleterious	-3.81	high_impact	4.99	0.58	damaging	0.49	neutral	4.61	24.40	deleterious	0.11	0.55	0.78	disease	0.83	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.37	0.9	2.14	6.63	0.72	P	0.84	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14226	14226	G	C	MI.23260	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	448	150	R	G	Cgt/Ggt	-2.81	0	0.01	benign	0.34	neutral	0.47	neutral	2.39	deleterious	-4.86	neutral	0.23	neutral_impact	-1.02	0.88	neutral	0.92	neutral	2.01	16.28	deleterious	0.38	0.5	0.12	neutral	0.18	neutral	0.43	neutral	0.26	neutral	5	0.45	neutral	0.57	deleterious	-6	neutral	0.27	neutral	-0.53	medium_impact	0.18	medium_impact	-1.99	low_impact	0.75	0.85	15.93	11.92	0.4	N	0.46	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14228	14228	C	A	MI.23261	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	446	149	G	V	gGg/gTg	-6.94	0	0	probably_damaging	1	neutral	0.67	neutral	2.28	deleterious	-5.73	deleterious	-6.44	high_impact	3.62	0.72	neutral	0.12	damaging	4.28	24.00	deleterious	0.23	0.45	0.58	disease	0.96	disease	0.84	disease	0.93	disease	9	1	deleterious	0.34	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	0.38	medium_impact	1.89	medium_impact	0.84	0.9	49.56	8.82	0.39	N	0.89	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14228	14228	C	T	MI.23262	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	446	149	G	E	gGg/gAg	-6.94	0	0	probably_damaging	1	neutral	0.18	neutral	2.31	deleterious	-5.32	deleterious	-5.72	high_impact	3.96	0.64	neutral	0.09	damaging	4.31	24.00	deleterious	0.35	0.5	0.61	disease	0.96	disease	0.86	disease	0.94	disease	9	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.16	medium_impact	2.18	high_impact	0.74	0.85	49.56	8.82	0.5	N	0.90	NA	NA	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14228	14228	C	G	MI.23263	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	446	149	G	A	gGg/gCg	-6.94	0	0	probably_damaging	1	neutral	0.43	neutral	2.31	deleterious	-4.4	deleterious	-3.77	medium_impact	2.68	0.8	neutral	0.79	neutral	2.25	17.86	deleterious	0.41	0.5	0.22	neutral	0.91	disease	0.78	disease	0.67	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.81	deleterious	-3.55	low_impact	0.14	medium_impact	1.11	medium_impact	0.83	0.85	49.56	8.82	0.35	N	0.37	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14229	14229	C	G	MI.23264	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	445	149	G	R	Ggg/Cgg	2.69	0.76	0	probably_damaging	1	neutral	0.26	neutral	2.26	deleterious	-5.95	deleterious	-5.79	high_impact	3.96	0.62	neutral	0.06	damaging	4.28	24.00	deleterious	0.24	0.45	0.69	disease	0.96	disease	0.87	disease	0.93	disease	9	1	deleterious	0.13	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.05	medium_impact	2.18	high_impact	0.89	0.9	49.56	8.82	0.5	N	0.91	NA	NA	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14229	14229	C	A	MI.23265	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	445	149	G	W	Ggg/Tgg	2.69	0.76	0	probably_damaging	1	neutral	0.5	neutral	2.26	deleterious	-8.54	deleterious	-6.49	high_impact	3.96	0.63	neutral	0.08	damaging	5.05	25.20	deleterious	0.24	0.45	0.93	disease	0.97	disease	0.87	disease	0.9	disease	8	1	deleterious	0.25	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.21	medium_impact	2.18	high_impact	0.68	0.85	49.56	8.82	0.49	N	0.91	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14231	14231	T	A	MI.23266	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	443	148	Y	F	tAt/tTt	0.17	0.13	0	probably_damaging	1	neutral	0.67	neutral	2.31	neutral	-2.93	deleterious	-2.98	low_impact	1.77	0.72	neutral	0.52	neutral	2.51	19.52	deleterious	0.42	0.55	0.33	neutral	0.46	neutral	0.43	neutral	0.46	neutral	1	1	deleterious	0.34	neutral	-2	neutral	0.74	deleterious	-3.55	low_impact	0.38	medium_impact	0.34	medium_impact	0.51	0.8	50	8.78	0.31	N	0.60	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14231	14231	T	G	MI.23267	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	443	148	Y	S	tAt/tCt	0.17	0.13	0	probably_damaging	1	neutral	0.57	neutral	2.46	deleterious	-4.84	deleterious	-6.6	low_impact	1.52	0.83	neutral	0.5	neutral	2.88	21.80	deleterious	0.25	0.45	0.14	neutral	0.53	disease	0.56	disease	0.44	neutral	1	1	deleterious	0.29	neutral	-2	neutral	0.71	deleterious	-3.55	low_impact	0.27	medium_impact	0.13	medium_impact	0.48	0.8	50	8.78	0.26	N	0.81	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14231	14231	T	C	MI.23268	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	443	148	Y	C	tAt/tGt	0.17	0.13	0	probably_damaging	1	neutral	0.22	neutral	2.28	deleterious	-6.77	deleterious	-5.84	low_impact	1.44	0.86	neutral	0.91	neutral	2.02	16.35	deleterious	0.34	0.5	0.14	neutral	0.72	disease	0.56	disease	0.59	disease	2	1	deleterious	0.11	neutral	-2	neutral	0.72	deleterious	-3.55	low_impact	-0.1	medium_impact	0.07	medium_impact	0.32	0.8	50	8.78	0.4	N	0.46	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14232	14232	A	G	MI.23269	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	442	148	Y	H	Tat/Cat	0.17	0.13	0	probably_damaging	1	neutral	0.49	neutral	2.31	deleterious	-5.03	deleterious	-3.67	medium_impact	2.51	0.83	neutral	0.37	neutral	2.42	18.93	deleterious	0.48	0.55	0.52	disease	0.65	disease	0.55	disease	0.65	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	0.2	medium_impact	0.96	medium_impact	0.40	0.8	50	8.78	0.34	N	0.73	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6112	6112	T	G	MI.2327	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	209	70	V	G	gTa/gGa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.57	neutral	-2.87	deleterious	-4.45	high_impact	3.54	0.59	damaging	0.61	neutral	3.67	23.30	deleterious	0.15	0.55	0.76	disease	0.76	disease	0.62	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.17	high_impact	0.61	0.9	2.14	6.63	0.5	P	0.71	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14232	14232	A	T	MI.23270	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	442	148	Y	N	Tat/Aat	0.17	0.13	0	probably_damaging	1	neutral	0.29	neutral	2.38	deleterious	-5.32	deleterious	-6.82	medium_impact	2.97	0.77	neutral	0.23	damaging	2.58	19.96	deleterious	0.33	0.5	0.44	neutral	0.77	disease	0.66	disease	0.74	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	-0.01	medium_impact	1.35	medium_impact	0.42	0.8	50	8.78	0.31	N	0.87	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14232	14232	A	C	MI.23271	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	442	148	Y	D	Tat/Gat	0.17	0.13	0	probably_damaging	1	neutral	0.18	neutral	2.38	deleterious	-5.53	deleterious	-7.64	medium_impact	2.34	0.77	neutral	0.24	damaging	2.60	20.20	deleterious	0.3	0.45	0.51	disease	0.84	disease	0.7	disease	0.78	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.83	deleterious	-3.55	low_impact	-0.16	medium_impact	0.82	medium_impact	0.48	0.8	50	8.78	0.3	N	0.94	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14233	14233	A	C	MI.23272	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	441	147	D	E	gaT/gaG	2.46	0.81	0.07	possibly_damaging	0.64	neutral	0.23	neutral	2.34	deleterious	-3.18	neutral	-0.59	low_impact	1.8	0.81	neutral	0.71	neutral	3.80	23.40	deleterious	0.54	0.6	0.2	neutral	0.76	disease	0.53	disease	0.71	disease	4	0.79	neutral	0.3	neutral	-3	neutral	0.56	deleterious	-1.03	low_impact	-0.09	medium_impact	0.37	medium_impact	0.78	0.85	46.46	7.68	0.38	N	0.57	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14234	14234	T	G	MI.23273	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	440	147	D	A	gAt/gCt	2.69	0.8	0	possibly_damaging	0.56	neutral	0.56	neutral	2.32	deleterious	-4.27	neutral	-0.46	low_impact	1.4	0.89	neutral	0.83	neutral	3.03	22.30	deleterious	0.35	0.5	0.27	neutral	0.76	disease	0.62	disease	0.6	disease	2	0.51	neutral	0.5	deleterious	-3	neutral	0.53	deleterious	-0.89	medium_impact	0.27	medium_impact	0.03	medium_impact	0.74	0.85	46.46	7.68	0.31	N	0.58	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14234	14234	T	C	MI.23274	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	440	147	D	G	gAt/gGt	2.69	0.8	0	possibly_damaging	0.56	neutral	0.45	neutral	2.34	deleterious	-4.54	neutral	-0.58	neutral_impact	0.64	0.9	neutral	0.91	neutral	2.71	20.80	deleterious	0.38	0.5	0.34	neutral	0.7	disease	0.49	neutral	0.57	disease	1	0.57	neutral	0.45	neutral	-3	neutral	0.57	deleterious	-0.89	medium_impact	0.16	medium_impact	-0.6	medium_impact	0.77	0.85	46.46	7.68	0.41	N	0.51	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14234	14234	T	A	MI.23275	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	440	147	D	V	gAt/gTt	2.69	0.8	0	probably_damaging	0.92	neutral	0.54	neutral	2.3	deleterious	-5.43	deleterious	-2.99	medium_impact	1.95	0.8	neutral	0.74	neutral	4.41	24.10	deleterious	0.36	0.5	0.47	neutral	0.85	disease	0.63	disease	0.64	disease	3	0.91	neutral	0.31	neutral	1	deleterious	0.77	deleterious	-1.77	low_impact	0.25	medium_impact	0.49	medium_impact	0.70	0.85	46.46	7.68	0.32	N	0.86	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14235	14235	C	A	MI.23276	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	439	147	D	Y	Gat/Tat	-1.67	0	0	probably_damaging	0.97	neutral	1	neutral	2.31	deleterious	-6.33	deleterious	-2.87	low_impact	1.4	0.86	neutral	0.78	neutral	4.62	24.50	deleterious	0.36	0.5	0.63	disease	0.83	disease	0.54	disease	0.64	disease	3	0.97	neutral	0.52	deleterious	-2	neutral	0.83	deleterious	-2.18	low_impact	1.87	high_impact	0.03	medium_impact	0.60	0.8	46.46	7.68	0.22	N	0.86	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14235	14235	C	T	MI.23277	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	439	147	D	N	Gat/Aat	-1.67	0	0	benign	0.06	neutral	0.3	neutral	2.35	deleterious	-4.05	neutral	0.84	neutral_impact	0.66	0.9	neutral	0.82	neutral	3.27	22.80	deleterious	0.69	0.75	0.28	neutral	0.73	disease	0.39	neutral	0.58	disease	2	0.67	neutral	0.62	deleterious	-6	neutral	0.22	neutral	0.3	medium_impact	0	medium_impact	-0.59	medium_impact	0.90	0.95	46.46	7.68	0.41	N	0.52	NA	NA	0.18	.	.	.	.	.	.	COSM1138253	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14235	14235	C	G	MI.23278	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	439	147	D	H	Gat/Cat	-1.67	0	0	probably_damaging	0.97	neutral	0.46	neutral	2.27	deleterious	-5.64	neutral	-1.52	medium_impact	1.95	0.79	neutral	0.62	neutral	3.97	23.60	deleterious	0.46	0.55	0.5	disease	0.69	disease	0.65	disease	0.74	disease	5	0.97	neutral	0.25	neutral	1	deleterious	0.76	deleterious	-2.18	low_impact	0.17	medium_impact	0.49	medium_impact	0.79	0.85	46.46	7.68	0.27	N	0.68	NA	NA	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14237	14237	T	G	MI.23279	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	437	146	Y	S	tAt/tCt	-0.29	0	0	probably_damaging	1	neutral	0.43	neutral	1.91	deleterious	-4.84	deleterious	-8.98	high_impact	3.63	0.63	neutral	0.08	damaging	4.14	23.80	deleterious	0.18	0.45	0.79	disease	0.95	disease	0.79	disease	0.91	disease	8	1	deleterious	0.22	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.14	medium_impact	1.9	medium_impact	0.49	0.8	50	8.58	0.4	N	0.96	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6112	6112	T	C	MI.2328	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	209	70	V	A	gTa/gCa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-0.04	deleterious	-2.53	medium_impact	2.62	0.57	damaging	0.59	neutral	3.45	23.00	deleterious	0.35	0.55	0.27	neutral	0.61	disease	0.59	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	1.32	medium_impact	0.32	0.9	2.14	6.63	0.53	P	0.47	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14237	14237	T	C	MI.23280	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	437	146	Y	C	tAt/tGt	-0.29	0	0	probably_damaging	1	neutral	0.18	neutral	1.86	deleterious	-6.77	deleterious	-8.98	high_impact	3.98	0.44	damaging	0.03	damaging	3.52	23.10	deleterious	0.22	0.45	0.91	disease	0.95	disease	0.84	disease	0.92	disease	8	1	deleterious	0.09	neutral	2	deleterious	0.93	deleterious	-3.55	low_impact	-0.16	medium_impact	2.19	high_impact	0.42	0.8	50	8.58	0.5	N	1.00	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14237	14237	T	A	MI.23281	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	437	146	Y	F	tAt/tTt	-0.29	0	0	probably_damaging	1	neutral	0.56	neutral	2	neutral	-2.93	deleterious	-3.99	medium_impact	2.65	0.69	neutral	0.17	damaging	3.85	23.40	deleterious	0.27	0.45	0.44	neutral	0.9	disease	0.75	disease	0.66	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.87	deleterious	-3.55	low_impact	0.27	medium_impact	1.08	medium_impact	0.69	0.85	50	8.58	0.28	N	0.80	NA	NA	0.61	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14238	14238	A	T	MI.23282	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	436	146	Y	N	Tat/Aat	2.92	0.98	0	probably_damaging	1	neutral	0.29	neutral	1.86	deleterious	-5.32	deleterious	-8.98	high_impact	3.98	0.51	damaging	0.06	damaging	3.76	23.30	deleterious	0.18	0.45	0.83	disease	0.96	disease	0.8	disease	0.92	disease	8	1	deleterious	0.15	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	-0.01	medium_impact	2.19	high_impact	0.51	0.8	50	8.58	0.64	P	1.00	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14238	14238	A	C	MI.23283	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	436	146	Y	D	Tat/Gat	2.92	0.98	0	probably_damaging	1	neutral	0.16	neutral	1.86	deleterious	-5.53	deleterious	-9.97	high_impact	3.98	0.49	damaging	0.04	damaging	3.77	23.40	deleterious	0.12	0.4	0.86	disease	0.96	disease	0.84	disease	0.92	disease	8	1	deleterious	0.08	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	-0.19	medium_impact	2.19	high_impact	0.46	0.8	50	8.58	0.62	P	0.97	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14238	14238	A	G	MI.23284	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	436	146	Y	H	Tat/Cat	2.92	0.98	0	probably_damaging	1	neutral	0.37	neutral	1.85	deleterious	-5.03	deleterious	-4.99	high_impact	3.98	0.56	damaging	0.05	damaging	3.77	23.40	deleterious	0.24	0.45	0.75	disease	0.93	disease	0.84	disease	0.89	disease	8	1	deleterious	0.19	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	0.08	medium_impact	2.19	high_impact	0.59	0.8	50	8.58	0.59	P	0.98	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14239	14239	C	G	MI.23285	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	435	145	L	F	ttG/ttC	4.98	0.99	0	probably_damaging	1	neutral	0.45	neutral	1.79	neutral	-2.83	deleterious	-3.65	medium_impact	2.25	0.8	neutral	0.29	neutral	3.87	23.50	deleterious	0.33	0.5	0.31	neutral	0.49	neutral	0.47	neutral	0.48	neutral	0	1	deleterious	0.23	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	0.16	medium_impact	0.75	medium_impact	0.74	0.85	49.12	8.84	0.55	P	0.69	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14239	14239	C	A	MI.23286	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	435	145	L	F	ttG/ttT	4.98	0.99	0	probably_damaging	1	neutral	0.45	neutral	1.79	neutral	-2.83	deleterious	-3.65	medium_impact	2.25	0.8	neutral	0.29	neutral	4.16	23.80	deleterious	0.33	0.5	0.31	neutral	0.49	neutral	0.47	neutral	0.48	neutral	0	1	deleterious	0.23	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	0.16	medium_impact	0.75	medium_impact	0.74	0.85	49.12	8.84	0.54	P	0.69	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14240	14240	A	C	MI.23287	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	434	145	L	W	tTg/tGg	-6.02	0	0	probably_damaging	1	neutral	0.14	neutral	1.64	deleterious	-6.43	deleterious	-5.69	high_impact	3.7	0.75	neutral	0.08	damaging	3.37	22.90	deleterious	0.11	0.4	0.85	disease	0.87	disease	0.64	disease	0.8	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.23	medium_impact	1.96	medium_impact	0.54	0.8	49.12	8.84	0.29	N	0.90	NA	NA	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14240	14240	A	G	MI.23288	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	434	145	L	S	tTg/tCg	-6.02	0	0	probably_damaging	1	neutral	0.22	neutral	1.68	deleterious	-4.62	deleterious	-5.58	high_impact	3.7	0.75	neutral	0.12	damaging	3.74	23.30	deleterious	0.12	0.4	0.71	disease	0.82	disease	0.68	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.1	medium_impact	1.96	medium_impact	0.55	0.8	49.12	8.84	0.34	N	0.88	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14241	14241	A	C	MI.23289	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	433	145	L	V	Ttg/Gtg	6.59	0.8	0	probably_damaging	1	neutral	0.52	neutral	1.73	neutral	-2.08	neutral	-2.44	medium_impact	2.46	0.77	neutral	0.23	damaging	3.26	22.80	deleterious	0.3	0.45	0.35	neutral	0.68	disease	0.5	neutral	0.53	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	0.23	medium_impact	0.92	medium_impact	0.76	0.85	49.12	8.84	0.36	N	0.55	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6114	6114	A	C	MI.2329	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	211	71	M	L	Ata/Cta	-13.29	0	0	probably_damaging	0.95	deleterious	0	neutral	2.75	neutral	-0.89	neutral	-1.86	high_impact	4.75	0.52	damaging	0.12	damaging	3.19	22.70	deleterious	0.47	0.55	0.36	neutral	0.84	disease	0.6	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.75	deleterious	-1.96	low_impact	-1.48	low_impact	3.29	high_impact	0.54	0.9	1.95	6.89	0.61	P	0.61	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14241	14241	A	T	MI.23290	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	433	145	L	M	Ttg/Atg	6.59	0.8	0	probably_damaging	1	neutral	0.31	neutral	1.71	neutral	-1.78	neutral	-1.57	low_impact	1.22	0.81	neutral	0.91	neutral	2.30	18.16	deleterious	0.24	0.45	0.16	neutral	0.1	neutral	0.3	neutral	0.28	neutral	4	1	deleterious	0.16	neutral	-2	neutral	0.68	deleterious	-3.55	low_impact	0.01	medium_impact	-0.12	medium_impact	0.72	0.85	49.12	8.84	0.51	N	0.23	NA	NA	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14243	14243	G	C	MI.23291	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	431	144	A	G	gCt/gGt	-6.02	0	0	probably_damaging	1	neutral	0.23	neutral	2.25	deleterious	-3.95	deleterious	-3.13	medium_impact	2	0.87	neutral	0.74	neutral	2.72	20.90	deleterious	0.22	0.45	0.52	disease	0.41	neutral	0.41	neutral	0.35	neutral	3	1	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	-0.09	medium_impact	0.54	medium_impact	0.86	0.9	49.12	8.59	0.46	N	0.62	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14243	14243	G	A	MI.23292	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	431	144	A	V	gCt/gTt	-6.02	0	0	probably_damaging	1	neutral	0.42	neutral	2.36	deleterious	-3.77	deleterious	-3.61	low_impact	1.7	0.72	neutral	0.44	neutral	4.40	24.10	deleterious	0.33	0.5	0.15	neutral	0.39	neutral	0.31	neutral	0.45	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-3.55	low_impact	0.13	medium_impact	0.28	medium_impact	0.93	0.95	49.12	8.59	0.32	N	0.71	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14243	14243	G	T	MI.23293	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	431	144	A	D	gCt/gAt	-6.02	0	0	probably_damaging	1	neutral	0.08	neutral	2.25	deleterious	-4.72	deleterious	-4.78	medium_impact	2.74	0.81	neutral	0.14	damaging	4.17	23.80	deleterious	0.19	0.45	0.59	disease	0.78	disease	0.58	disease	0.77	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.84	deleterious	-3.55	low_impact	-0.38	medium_impact	1.16	medium_impact	0.81	0.85	49.12	8.59	0.35	N	0.93	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14244	14244	C	G	MI.23294	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	430	144	A	P	Gct/Cct	1.77	0	0	probably_damaging	1	neutral	0.08	neutral	2.24	deleterious	-5.07	deleterious	-4.26	medium_impact	2.94	0.77	neutral	0.08	damaging	4.26	23.90	deleterious	0.13	0.4	0.6	disease	0.83	disease	0.42	neutral	0.75	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.87	deleterious	-3.55	low_impact	-0.38	medium_impact	1.32	medium_impact	0.90	0.95	49.12	8.59	0.31	N	0.90	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14244	14244	C	T	MI.23295	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	430	144	A	T	Gct/Act	1.77	0	0	probably_damaging	1	neutral	0.23	neutral	2.29	deleterious	-3.67	deleterious	-3.06	medium_impact	2.6	0.8	neutral	0.27	damaging	4.58	24.40	deleterious	0.43	0.55	0.34	neutral	0.39	neutral	0.42	neutral	0.47	neutral	1	1	deleterious	0.12	neutral	1	deleterious	0.71	deleterious	-3.55	low_impact	-0.09	medium_impact	1.04	medium_impact	0.94	0.95	49.12	8.59	0.38	N	0.76	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14244	14244	C	A	MI.23296	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	430	144	A	S	Gct/Tct	1.77	0	0	probably_damaging	1	neutral	0.32	neutral	2.31	deleterious	-3.23	neutral	-1.7	low_impact	1.47	0.83	neutral	0.82	neutral	3.11	22.50	deleterious	0.44	0.55	0.37	neutral	0.37	neutral	0.26	neutral	0.46	neutral	1	1	deleterious	0.16	neutral	-2	neutral	0.75	deleterious	-3.55	low_impact	0.03	medium_impact	0.09	medium_impact	0.88	0.9	49.12	8.59	0.42	N	0.60	NA	NA	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14246	14246	C	G	MI.23297	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	428	143	G	A	gGg/gCg	-7.62	0	0	benign	0.15	neutral	0.46	neutral	2.35	deleterious	-4.4	neutral	1.79	neutral_impact	-0.15	0.9	neutral	0.92	neutral	0.82	9.58	deleterious	0.27	0.45	0.14	neutral	0.18	neutral	0.16	neutral	0.27	neutral	5	0.46	neutral	0.66	deleterious	-6	neutral	0.18	neutral	-0.11	medium_impact	0.17	medium_impact	-1.27	low_impact	0.51	0.8	19.47	13.18	0.45	N	0.27	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14246	14246	C	A	MI.23298	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	428	143	G	V	gGg/gTg	-7.62	0	0	possibly_damaging	0.85	neutral	0.68	neutral	2.32	deleterious	-5.73	neutral	-1.82	low_impact	1.84	0.7	neutral	0.67	neutral	4.37	24.10	deleterious	0.22	0.45	0.38	neutral	0.82	disease	0.6	disease	0.76	disease	5	0.82	neutral	0.42	neutral	-3	neutral	0.76	deleterious	-1.49	low_impact	0.39	medium_impact	0.4	medium_impact	0.63	0.8	19.47	13.18	0.27	N	0.73	NA	NA	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14246	14246	C	T	MI.23299	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	428	143	G	E	gGg/gAg	-7.62	0	0	possibly_damaging	0.89	neutral	0.22	neutral	2.33	deleterious	-5.32	neutral	-2.03	medium_impact	2.93	0.73	neutral	0.56	neutral	4.34	24.00	deleterious	0.2	0.45	0.42	neutral	0.86	disease	0.69	disease	0.81	disease	6	0.92	neutral	0.17	neutral	0	NA	0.80	deleterious	-1.63	low_impact	-0.1	medium_impact	1.31	medium_impact	0.68	0.85	19.47	13.18	0.37	N	0.80	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8636	8636	T	G	MI.233	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	110	37	L	R	cTc/cGc	0.59	0.38	0	probably_damaging	0.91	neutral	0.05	neutral	4.34	neutral	-2.99	deleterious	-2.52	medium_impact	2.51	0.82	neutral	0.44	neutral	3.96	23.60	deleterious	0.36	0.65	0.73	disease	0.82	disease	0.76	disease	0.81	disease	6	0.98	deleterious	0.07	neutral	1	deleterious	0.82	deleterious	-1.71	low_impact	-0.43	medium_impact	1.05	medium_impact	0.56	0.9	20.35	20.89	0.27	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6114	6114	A	T	MI.2330	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	211	71	M	L	Ata/Tta	-13.29	0	0	probably_damaging	0.95	deleterious	0	neutral	2.75	neutral	-0.89	neutral	-1.86	high_impact	4.75	0.52	damaging	0.12	damaging	3.28	22.80	deleterious	0.47	0.55	0.36	neutral	0.84	disease	0.6	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.75	deleterious	-1.96	low_impact	-1.48	low_impact	3.29	high_impact	0.54	0.9	1.95	6.89	0.61	P	0.61	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14247	14247	C	A	MI.23300	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	427	143	G	W	Ggg/Tgg	3.15	0.34	0	probably_damaging	0.99	neutral	0.11	neutral	2.26	deleterious	-8.54	deleterious	-3.81	medium_impact	2.93	0.73	neutral	0.5	neutral	4.99	25.10	deleterious	0.14	0.4	0.86	disease	0.91	disease	0.65	disease	0.83	disease	6	1	deleterious	0.06	neutral	1	deleterious	0.87	deleterious	-2.63	low_impact	-0.3	medium_impact	1.31	medium_impact	0.61	0.8	19.47	13.18	0.4	N	0.84	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14247	14247	C	G	MI.23301	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	427	143	G	R	Ggg/Cgg	3.15	0.34	0	probably_damaging	0.96	neutral	0.23	neutral	2.32	deleterious	-5.95	neutral	-2.18	medium_impact	2.93	0.71	neutral	0.49	neutral	4.34	24.00	deleterious	0.18	0.45	0.49	neutral	0.88	disease	0.71	disease	0.82	disease	6	0.97	neutral	0.14	neutral	1	deleterious	0.84	deleterious	-2.06	low_impact	-0.09	medium_impact	1.31	medium_impact	0.80	0.85	19.47	13.18	0.45	N	0.75	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14249	14249	G	A	MI.23302	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	425	142	A	V	gCg/gTg	-5.56	0	0.01	benign	0.36	neutral	0.57	neutral	2.78	deleterious	-3.77	neutral	2.07	neutral_impact	-0.52	0.87	neutral	0.96	neutral	1.59	13.81	neutral	0.24	0.45	0.15	neutral	0.1	neutral	0.23	neutral	0.26	neutral	5	0.36	neutral	0.61	deleterious	-6	neutral	0.45	deleterious	-0.57	medium_impact	0.27	medium_impact	-1.58	low_impact	0.78	0.85	11.95	13.75	0.31	N	0.25	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14249	14249	G	T	MI.23303	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	425	142	A	E	gCg/gAg	-5.56	0	0.01	probably_damaging	0.99	neutral	0.27	neutral	2.23	deleterious	-4.42	neutral	-2.37	medium_impact	2.67	0.77	neutral	0.6	neutral	4.12	23.80	deleterious	0.11	0.4	0.52	disease	0.83	disease	0.66	disease	0.8	disease	6	0.99	deleterious	0.14	neutral	1	deleterious	0.84	deleterious	-2.63	low_impact	-0.03	medium_impact	1.1	medium_impact	0.84	0.9	11.95	13.75	0.3	N	0.81	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14249	14249	G	C	MI.23304	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	425	142	A	G	gCg/gGg	-5.56	0	0.01	probably_damaging	0.95	neutral	0.43	neutral	2.24	deleterious	-3.95	neutral	-2.19	low_impact	1.57	0.87	neutral	0.93	neutral	2.65	20.50	deleterious	0.11	0.4	0.52	disease	0.57	disease	0.47	neutral	0.48	neutral	0	0.94	neutral	0.24	neutral	-2	neutral	0.76	deleterious	-1.97	low_impact	0.14	medium_impact	0.18	medium_impact	0.75	0.85	11.95	13.75	0.38	N	0.61	NA	NA	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14250	14250	C	A	MI.23305	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	424	142	A	S	Gcg/Tcg	2	0.01	0	probably_damaging	0.95	neutral	0.43	neutral	2.25	deleterious	-3.23	neutral	-1.72	low_impact	1.86	0.82	neutral	0.73	neutral	3.14	22.60	deleterious	0.25	0.45	0.38	neutral	0.55	disease	0.31	neutral	0.53	disease	1	0.94	neutral	0.24	neutral	-2	neutral	0.75	deleterious	-1.97	low_impact	0.14	medium_impact	0.42	medium_impact	0.93	0.95	11.95	13.75	0.37	N	0.58	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14250	14250	C	G	MI.23306	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	424	142	A	P	Gcg/Ccg	2	0.01	0	probably_damaging	0.99	neutral	0.2	neutral	2.21	deleterious	-5.07	neutral	-2.37	medium_impact	2.67	0.76	neutral	0.43	neutral	4.17	23.80	deleterious	0.09	0.35	0.6	disease	0.89	disease	0.49	neutral	0.79	disease	6	0.99	deleterious	0.11	neutral	1	deleterious	0.88	deleterious	-2.63	low_impact	-0.13	medium_impact	1.1	medium_impact	0.88	0.9	11.95	13.75	0.39	N	0.79	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14250	14250	C	T	MI.23307	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	424	142	A	T	Gcg/Acg	2	0.01	0	probably_damaging	0.94	neutral	0.42	neutral	2.27	deleterious	-3.67	neutral	-0.58	low_impact	1.63	0.78	neutral	0.72	neutral	3.53	23.10	deleterious	0.32	0.5	0.31	neutral	0.51	disease	0.33	neutral	0.52	disease	0	0.94	neutral	0.24	neutral	-2	neutral	0.69	deleterious	-1.89	low_impact	0.13	medium_impact	0.23	medium_impact	0.79	0.85	11.95	13.75	0.38	N	0.52	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14252	14252	C	T	MI.23308	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	422	141	G	D	gGt/gAt	-3.5	0	0	probably_damaging	1	neutral	0.21	neutral	1.1	deleterious	-6.61	deleterious	-6.98	high_impact	4	0.52	damaging	0.04	damaging	4.24	23.90	deleterious	0.18	0.45	0.83	disease	0.93	disease	0.86	disease	0.91	disease	8	1	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	-0.11	medium_impact	2.21	high_impact	0.56	0.8	46.46	8.22	0.38	N	0.96	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14252	14252	C	G	MI.23309	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	422	141	G	A	gGt/gCt	-3.5	0	0	probably_damaging	1	neutral	0.51	neutral	1.17	deleterious	-5.51	deleterious	-5.98	high_impact	3.65	0.63	neutral	0.09	damaging	3.50	23.10	deleterious	0.28	0.45	0.7	disease	0.84	disease	0.71	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0.22	medium_impact	1.92	medium_impact	0.80	0.85	46.46	8.22	0.27	N	0.78	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6114	6114	A	G	MI.2331	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	211	71	M	V	Ata/Gta	-13.29	0	0	probably_damaging	0.97	deleterious	0	neutral	2.76	neutral	-0.6	deleterious	-2.54	high_impact	3.82	0.55	damaging	0.09	damaging	2.69	20.70	deleterious	0.47	0.55	0.24	neutral	0.91	disease	0.63	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-2.18	low_impact	-1.48	low_impact	2.43	high_impact	0.59	0.9	1.95	6.89	0.26	N	0.88	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14252	14252	C	A	MI.23310	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	422	141	G	V	gGt/gTt	-3.5	0	0	probably_damaging	1	neutral	0.51	neutral	1.1	deleterious	-6.92	deleterious	-8.97	high_impact	4	0.39	damaging	0.04	damaging	4.38	24.10	deleterious	0.16	0.45	0.86	disease	0.93	disease	0.8	disease	0.91	disease	8	1	deleterious	0.26	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	0.22	medium_impact	2.21	high_impact	0.70	0.85	46.46	8.22	0.57	P	0.98	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14253	14253	C	A	MI.23311	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	421	141	G	C	Ggt/Tgt	2	0.44	0	probably_damaging	1	neutral	0.18	neutral	1.08	deleterious	-8.06	deleterious	-8.78	high_impact	4	0.46	damaging	0.03	damaging	4.77	24.70	deleterious	0.15	0.4	0.91	disease	0.92	disease	0.8	disease	0.89	disease	8	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	-0.16	medium_impact	2.21	high_impact	0.64	0.8	46.46	8.22	0.51	N	0.97	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14253	14253	C	T	MI.23312	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	421	141	G	S	Ggt/Agt	2	0.44	0	probably_damaging	1	neutral	0.41	neutral	1.15	deleterious	-5.78	deleterious	-5.98	medium_impact	3.31	0.57	damaging	0.06	damaging	4.48	24.20	deleterious	0.26	0.45	0.73	disease	0.89	disease	0.71	disease	0.78	disease	6	1	deleterious	0.21	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	0.12	medium_impact	1.63	medium_impact	0.75	0.85	46.46	8.22	0.32	N	1.00	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14253	14253	C	G	MI.23313	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	421	141	G	R	Ggt/Cgt	2	0.44	0	probably_damaging	1	neutral	0.35	neutral	1.09	deleterious	-7.13	deleterious	-7.98	high_impact	4	0.48	damaging	0.04	damaging	4.23	23.90	deleterious	0.17	0.45	0.87	disease	0.91	disease	0.87	disease	0.9	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.06	medium_impact	2.21	high_impact	0.77	0.85	46.46	8.22	0.52	P	1.00	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14254	14254	A	C	MI.23314	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	420	140	I	M	atT/atG	3.15	0.46	0	probably_damaging	0.94	neutral	0.24	neutral	2.29	deleterious	-4.19	neutral	0.61	neutral_impact	0.59	0.87	neutral	0.93	neutral	0.66	8.53	deleterious	0.38	0.5	0.15	neutral	0.26	neutral	0.18	neutral	0.43	neutral	1	0.96	neutral	0.15	neutral	-2	neutral	0.62	deleterious	-1.89	low_impact	-0.07	medium_impact	-0.65	medium_impact	0.79	0.85	44.25	8.21	0.5	N	0.18	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14254	14254	A	T	MI.23315	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	420	140	I	M	atT/atA	3.15	0.46	0	probably_damaging	0.94	neutral	0.24	neutral	2.29	deleterious	-4.19	neutral	0.61	neutral_impact	0.59	0.87	neutral	0.93	neutral	0.75	9.15	deleterious	0.38	0.5	0.15	neutral	0.26	neutral	0.18	neutral	0.43	neutral	1	0.96	neutral	0.15	neutral	-2	neutral	0.62	deleterious	-1.89	low_impact	-0.07	medium_impact	-0.65	medium_impact	0.79	0.85	44.25	8.21	0.51	P	0.18	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14255	14255	A	G	MI.23316	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	419	140	I	T	aTt/aCt	-2.81	0	0	benign	0.03	neutral	0.48	neutral	2.31	deleterious	-4.26	neutral	-0.96	neutral_impact	0.7	0.91	neutral	0.84	neutral	1.64	14.06	neutral	0.33	0.5	0.23	neutral	0.42	neutral	0.36	neutral	0.44	neutral	1	0.49	neutral	0.73	deleterious	-6	neutral	0.14	neutral	0.59	medium_impact	0.19	medium_impact	-0.55	medium_impact	0.56	0.8	44.25	8.21	0.46	N	0.52	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14255	14255	A	C	MI.23317	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	419	140	I	S	aTt/aGt	-2.81	0	0	benign	0.39	neutral	0.52	neutral	2.41	deleterious	-4.68	neutral	-1.59	neutral_impact	0.24	0.86	neutral	0.97	neutral	2.14	17.14	deleterious	0.3	0.45	0.15	neutral	0.25	neutral	0.22	neutral	0.42	neutral	2	0.42	neutral	0.57	deleterious	-6	neutral	0.39	neutral	-0.62	medium_impact	0.23	medium_impact	-0.94	medium_impact	0.53	0.8	44.25	8.21	0.37	N	0.49	NA	NA	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14255	14255	A	T	MI.23318	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	419	140	I	N	aTt/aAt	-2.81	0	0	possibly_damaging	0.77	neutral	0.38	neutral	2.27	deleterious	-5.64	deleterious	-3.06	low_impact	1.32	0.84	neutral	0.8	neutral	2.74	21.00	deleterious	0.35	0.5	0.35	neutral	0.75	disease	0.37	neutral	0.57	disease	1	0.79	neutral	0.31	neutral	-3	neutral	0.69	deleterious	-1.28	low_impact	0.09	medium_impact	-0.03	medium_impact	0.46	0.8	44.25	8.21	0.37	N	0.81	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14256	14256	T	C	MI.23319	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	418	140	I	V	Att/Gtt	-0.75	0	0	benign	0.28	neutral	0.55	neutral	2.36	neutral	-1.8	neutral	0.33	neutral_impact	0.28	0.88	neutral	0.94	neutral	-1.17	0.01	neutral	0.35	0.5	0.13	neutral	0.21	neutral	0.2	neutral	0.36	neutral	3	0.35	neutral	0.64	deleterious	-6	neutral	0.28	neutral	-0.42	medium_impact	0.26	medium_impact	-0.91	medium_impact	0.54	0.8	44.25	8.21	0.38	N	0.56	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6115	6115	T	C	MI.2332	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	212	71	M	T	aTa/aCa	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.74	neutral	0.28	deleterious	-3.84	medium_impact	3.01	0.55	damaging	0.13	damaging	2.90	21.90	deleterious	0.31	0.55	0.31	neutral	0.89	disease	0.66	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.86	deleterious	-2.64	low_impact	-1.48	low_impact	1.68	medium_impact	0.38	0.9	1.95	6.89	0.41	N	0.79	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14256	14256	T	A	MI.23320	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	418	140	I	F	Att/Ttt	-0.75	0	0	possibly_damaging	0.87	neutral	0.71	neutral	2.27	deleterious	-4.31	neutral	-1.88	low_impact	1.56	0.72	neutral	0.41	neutral	3.03	22.30	deleterious	0.35	0.5	0.31	neutral	0.61	disease	0.34	neutral	0.53	disease	1	0.85	neutral	0.42	neutral	-3	neutral	0.67	deleterious	-1.55	low_impact	0.42	medium_impact	0.17	medium_impact	0.77	0.85	44.25	8.21	0.34	N	0.52	NA	NA	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14256	14256	T	G	MI.23321	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	418	140	I	L	Att/Ctt	-0.75	0	0	benign	0.28	neutral	0.7	neutral	2.36	neutral	-2.08	neutral	-0.12	low_impact	1.05	0.84	neutral	0.74	neutral	0.88	9.96	deleterious	0.3	0.45	0.16	neutral	0.45	neutral	0.31	neutral	0.46	neutral	1	0.22	neutral	0.71	deleterious	-6	neutral	0.37	neutral	-0.42	medium_impact	0.41	medium_impact	-0.26	medium_impact	0.73	0.85	44.25	8.21	0.28	N	0.56	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14258	14258	G	A	MI.23322	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	416	139	P	L	cCt/cTt	-1.44	0	0	benign	0.37	neutral	0.68	neutral	2.47	deleterious	-5.32	neutral	-0.82	neutral_impact	0.32	0.79	neutral	0.72	neutral	0.29	5.60	deleterious	0.44	0.55	0.09	neutral	0.28	neutral	0.36	neutral	0.41	neutral	2	0.29	neutral	0.66	deleterious	-6	neutral	0.28	neutral	-0.58	medium_impact	0.39	medium_impact	-0.87	medium_impact	0.91	0.95	48.23	8.84	0.31	N	0.72	NA	NA	0.17	rs202227543	.	.	.	.	.	.	.	.	G14258A	LHON synergistic combo 10680A + 12033G + 14258A, also combo 14258A + 14582G	+	-	Reported: individually neutral variants causing LHON in combination	1	N	.	N	neutral
chrM	14258	14258	G	C	MI.23323	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	416	139	P	R	cCt/cGt	-1.44	0	0	possibly_damaging	0.7	neutral	0.34	neutral	2.32	deleterious	-5.5	neutral	-1.26	low_impact	1.84	0.83	neutral	0.51	neutral	0.07	3.34	deleterious	0.36	0.5	0.23	neutral	0.36	neutral	0.46	neutral	0.45	neutral	1	0.74	neutral	0.32	neutral	-3	neutral	0.52	deleterious	-1.13	low_impact	0.05	medium_impact	0.4	medium_impact	0.72	0.85	48.23	8.84	0.42	N	0.68	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14258	14258	G	T	MI.23324	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	416	139	P	H	cCt/cAt	-1.44	0	0	possibly_damaging	0.9	neutral	0.53	neutral	2.31	deleterious	-6.63	neutral	-1.07	low_impact	1.5	0.81	neutral	0.52	neutral	1.47	13.14	neutral	0.38	0.5	0.32	neutral	0.21	neutral	0.41	neutral	0.37	neutral	3	0.88	neutral	0.32	neutral	-3	neutral	0.61	deleterious	-1.67	low_impact	0.24	medium_impact	0.12	medium_impact	0.72	0.85	48.23	8.84	0.37	N	0.71	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14259	14259	G	T	MI.23325	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	415	139	P	T	Cct/Act	-0.52	0	0	benign	0.02	neutral	0.39	neutral	2.39	deleterious	-5.02	neutral	0.18	neutral_impact	0.74	0.9	neutral	0.85	neutral	-0.24	0.89	neutral	0.37	0.5	0.14	neutral	0.12	neutral	0.18	neutral	0.31	neutral	4	0.6	neutral	0.69	deleterious	-6	neutral	0.08	neutral	0.75	medium_impact	0.1	medium_impact	-0.52	medium_impact	0.76	0.85	48.23	8.84	0.56	N	0.45	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14259	14259	G	C	MI.23326	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	415	139	P	A	Cct/Gct	-0.52	0	0	benign	0.18	neutral	0.51	neutral	2.42	deleterious	-4.34	neutral	1.11	neutral_impact	0.26	0.9	neutral	0.98	neutral	-0.94	0.02	neutral	0.37	0.5	0.1	neutral	0.12	neutral	0.33	neutral	0.3	neutral	4	0.39	neutral	0.67	deleterious	-6	neutral	0.18	neutral	-0.19	medium_impact	0.22	medium_impact	-0.92	medium_impact	0.68	0.85	48.23	8.84	0.46	N	0.22	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14259	14259	G	A	MI.23327	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	415	139	P	S	Cct/Tct	-0.52	0	0	benign	0.01	neutral	0.41	neutral	2.37	deleterious	-4.6	neutral	0.9	neutral_impact	-0.8	0.96	neutral	0.96	neutral	0.00	2.62	deleterious	0.5	0.6	0.16	neutral	0.13	neutral	0.17	neutral	0.3	neutral	4	0.58	neutral	0.7	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	0.12	medium_impact	-1.81	low_impact	0.40	0.8	48.23	8.84	0.49	N	0.22	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14260	14260	A	C	MI.23328	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	414	138	D	E	gaT/gaG	-1.89	0	0	probably_damaging	1	neutral	0.48	neutral	1.88	deleterious	-3.18	neutral	-0.93	low_impact	1.82	0.88	neutral	0.86	neutral	1.64	14.09	neutral	0.56	0.6	0.16	neutral	0.69	disease	0.44	neutral	0.5	neutral	0	1	deleterious	0.24	neutral	-2	neutral	0.73	deleterious	-3.55	low_impact	0.19	medium_impact	0.39	medium_impact	0.75	0.85	44.69	8.06	0.33	N	0.19	NA	NA	0.28	rs386829207	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14260	14260	A	T	MI.23329	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	414	138	D	E	gaT/gaA	-1.89	0	0	probably_damaging	1	neutral	0.48	neutral	1.88	deleterious	-3.18	neutral	-0.93	low_impact	1.82	0.88	neutral	0.86	neutral	1.75	14.72	neutral	0.56	0.6	0.16	neutral	0.69	disease	0.44	neutral	0.5	neutral	0	1	deleterious	0.24	neutral	-2	neutral	0.73	deleterious	-3.55	low_impact	0.19	medium_impact	0.39	medium_impact	0.75	0.85	44.69	8.06	0.32	N	0.19	NA	NA	0.28	rs386829207	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6115	6115	T	A	MI.2333	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	212	71	M	K	aTa/aAa	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.61	neutral	-2.71	deleterious	-3.85	high_impact	5.1	0.55	damaging	0.07	damaging	4.02	23.60	deleterious	0.17	0.55	0.67	disease	0.94	disease	0.74	disease	0.88	disease	8	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.64	low_impact	-1.48	low_impact	3.61	high_impact	0.47	0.9	1.95	6.89	0.73	P	0.93	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14261	14261	T	G	MI.23330	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	413	138	D	A	gAt/gCt	-0.29	0	0	probably_damaging	1	neutral	0.66	neutral	1.73	deleterious	-4.27	deleterious	-5.03	high_impact	3.83	0.65	neutral	0.25	damaging	4.08	23.70	deleterious	0.39	0.5	0.46	neutral	0.91	disease	0.76	disease	0.81	disease	6	1	deleterious	0.33	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	0.37	medium_impact	2.07	high_impact	0.75	0.85	44.69	8.06	0.4	N	0.83	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14261	14261	T	C	MI.23331	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	413	138	D	G	gAt/gGt	-0.29	0	0	probably_damaging	1	neutral	0.42	neutral	1.73	deleterious	-4.54	deleterious	-4.35	medium_impact	2.48	0.76	neutral	0.8	neutral	2.58	19.99	deleterious	0.32	0.5	0.28	neutral	0.89	disease	0.75	disease	0.78	disease	6	1	deleterious	0.21	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	0.13	medium_impact	0.94	medium_impact	0.73	0.85	44.69	8.06	0.41	N	0.29	NA	NA	0.57	.	.	.	.	.	.	COSM1155549	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14261	14261	T	A	MI.23332	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	413	138	D	V	gAt/gTt	-0.29	0	0	probably_damaging	1	neutral	0.56	neutral	1.69	deleterious	-5.43	deleterious	-6.23	medium_impact	3.48	0.62	neutral	0.2	damaging	4.25	23.90	deleterious	0.31	0.45	0.69	disease	0.95	disease	0.78	disease	0.9	disease	8	1	deleterious	0.28	neutral	1	deleterious	0.87	deleterious	-3.55	low_impact	0.27	medium_impact	1.78	medium_impact	0.64	0.8	44.69	8.06	0.37	N	0.90	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14262	14262	C	T	MI.23333	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	412	138	D	N	Gat/Aat	1.77	0.85	0	probably_damaging	1	neutral	0.42	neutral	1.75	deleterious	-4.05	deleterious	-3.13	medium_impact	3.28	0.64	neutral	0.2	damaging	4.59	24.40	deleterious	0.65	0.7	0.38	neutral	0.89	disease	0.7	disease	0.77	disease	5	1	deleterious	0.21	neutral	1	deleterious	0.80	deleterious	-3.55	low_impact	0.13	medium_impact	1.61	medium_impact	0.87	0.9	44.69	8.06	0.41	N	0.61	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14262	14262	C	G	MI.23334	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	412	138	D	H	Gat/Cat	1.77	0.85	0	probably_damaging	1	neutral	0.55	neutral	1.69	deleterious	-5.64	deleterious	-4.33	high_impact	3.83	0.66	neutral	0.18	damaging	4.00	23.60	deleterious	0.38	0.5	0.63	disease	0.89	disease	0.81	disease	0.84	disease	7	1	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.26	medium_impact	2.07	high_impact	0.73	0.85	44.69	8.06	0.48	N	0.79	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14262	14262	C	A	MI.23335	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	412	138	D	Y	Gat/Tat	1.77	0.85	0	probably_damaging	1	neutral	1	neutral	1.68	deleterious	-6.33	deleterious	-6.19	high_impact	3.83	0.72	neutral	0.31	neutral	4.62	24.50	deleterious	0.34	0.5	0.78	disease	0.94	disease	0.81	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.89	deleterious	-3.55	low_impact	1.87	high_impact	2.07	high_impact	0.56	0.8	44.69	8.06	0.46	N	0.95	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14263	14263	C	G	MI.23336	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	411	137	E	D	gaG/gaC	4.29	0.87	0	benign	0.37	neutral	0.19	neutral	2.22	deleterious	-3.1	neutral	-2.03	medium_impact	2.49	0.83	neutral	0.53	neutral	2.29	18.13	deleterious	0.37	0.5	0.28	neutral	0.41	neutral	0.41	neutral	0.45	neutral	1	0.78	neutral	0.41	neutral	-3	neutral	0.45	deleterious	-0.58	medium_impact	-0.14	medium_impact	0.95	medium_impact	0.90	0.95	49.56	8.85	0.51	P	0.68	NA	NA	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14263	14263	C	A	MI.23337	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	411	137	E	D	gaG/gaT	4.29	0.87	0	benign	0.37	neutral	0.19	neutral	2.22	deleterious	-3.1	neutral	-2.03	medium_impact	2.49	0.83	neutral	0.53	neutral	2.53	19.65	deleterious	0.37	0.5	0.28	neutral	0.41	neutral	0.41	neutral	0.45	neutral	1	0.78	neutral	0.41	neutral	-3	neutral	0.45	deleterious	-0.58	medium_impact	-0.14	medium_impact	0.95	medium_impact	0.90	0.95	49.56	8.85	0.5	N	0.68	NA	NA	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14264	14264	T	A	MI.23338	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	410	137	E	V	gAg/gTg	-3.96	0	0	possibly_damaging	0.7	neutral	0.47	neutral	2.24	deleterious	-4.86	deleterious	-5.05	medium_impact	2.04	0.79	neutral	0.68	neutral	4.27	24.00	deleterious	0.28	0.45	0.4	neutral	0.53	disease	0.35	neutral	0.47	neutral	1	0.69	neutral	0.39	neutral	0	NA	0.64	deleterious	-1.13	low_impact	0.18	medium_impact	0.57	medium_impact	0.81	0.85	49.56	8.85	0.39	N	0.82	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14264	14264	T	C	MI.23339	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	410	137	E	G	gAg/gGg	-3.96	0	0	benign	0.02	neutral	0.35	neutral	2.3	deleterious	-4.34	deleterious	-3.75	neutral_impact	0.3	0.92	neutral	0.91	neutral	1.10	11.22	neutral	0.4	0.5	0.2	neutral	0.11	neutral	0.4	neutral	0.27	neutral	5	0.64	neutral	0.67	deleterious	-6	neutral	0.12	neutral	0.75	medium_impact	0.06	medium_impact	-0.89	medium_impact	0.70	0.85	49.56	8.85	0.53	N	0.31	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6116	6116	A	T	MI.2334	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	213	71	M	I	atA/atT	7.53	1	0.01	probably_damaging	0.98	deleterious	0	neutral	2.8	neutral	-0.6	deleterious	-2.52	high_impact	3.78	0.53	damaging	0.1	damaging	3.41	23.00	deleterious	0.42	0.55	0.24	neutral	0.91	disease	0.61	disease	0.54	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	2.39	high_impact	0.61	0.9	1.95	6.89	0.52	P	0.87	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14264	14264	T	G	MI.23340	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	410	137	E	A	gAg/gCg	-3.96	0	0	benign	0.37	neutral	0.47	neutral	2.27	deleterious	-3.9	deleterious	-3.77	medium_impact	2.15	0.75	neutral	0.76	neutral	2.33	18.38	deleterious	0.35	0.5	0.21	neutral	0.37	neutral	0.49	neutral	0.45	neutral	1	0.46	neutral	0.55	deleterious	-3	neutral	0.39	neutral	-0.58	medium_impact	0.18	medium_impact	0.66	medium_impact	0.84	0.9	49.56	8.85	0.39	N	0.59	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14265	14265	C	G	MI.23341	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	409	137	E	Q	Gag/Cag	0.63	0.02	0	possibly_damaging	0.76	neutral	0.26	neutral	2.24	deleterious	-4.06	neutral	-2.02	low_impact	1.68	0.89	neutral	0.77	neutral	2.38	18.67	deleterious	0.48	0.55	0.3	neutral	0.23	neutral	0.28	neutral	0.42	neutral	2	0.83	neutral	0.25	neutral	-3	neutral	0.58	deleterious	-1.26	low_impact	-0.05	medium_impact	0.27	medium_impact	0.89	0.9	49.56	8.85	0.51	N	0.48	NA	NA	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14265	14265	C	T	MI.23342	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	409	137	E	K	Gag/Aag	0.63	0.02	0	possibly_damaging	0.49	neutral	0.27	neutral	2.27	deleterious	-3.58	neutral	-2.43	medium_impact	2.08	0.87	neutral	0.53	neutral	2.13	17.08	deleterious	0.4	0.5	0.24	neutral	0.56	disease	0.5	neutral	0.46	neutral	1	0.7	neutral	0.39	neutral	0	NA	0.54	deleterious	-0.78	medium_impact	-0.03	medium_impact	0.6	medium_impact	0.89	0.9	49.56	8.85	0.43	N	0.78	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14267	14267	C	A	MI.23343	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	407	136	R	L	cGg/cTg	-1.21	0	0	probably_damaging	0.92	neutral	0.73	neutral	2.13	deleterious	-4.56	deleterious	-3.19	medium_impact	2.16	0.84	neutral	0.72	neutral	2.70	20.80	deleterious	0.41	0.5	0.25	neutral	0.91	disease	0.58	disease	0.59	disease	2	0.9	neutral	0.41	neutral	1	deleterious	0.76	deleterious	-1.77	low_impact	0.45	medium_impact	0.67	medium_impact	0.51	0.8	18.14	17.08	0.23	N	0.57	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14267	14267	C	G	MI.23344	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	407	136	R	P	cGg/cCg	-1.21	0	0	probably_damaging	0.98	neutral	0.19	neutral	2.08	deleterious	-5.6	deleterious	-2.85	medium_impact	3.17	0.64	neutral	0.16	damaging	3.23	22.80	deleterious	0.23	0.45	0.57	disease	0.94	disease	0.66	disease	0.82	disease	6	0.99	deleterious	0.11	neutral	1	deleterious	0.84	deleterious	-2.35	low_impact	-0.14	medium_impact	1.52	medium_impact	0.62	0.8	18.14	17.08	0.3	N	0.83	NA	NA	0.61	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14267	14267	C	T	MI.23345	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	407	136	R	Q	cGg/cAg	-1.21	0	0	probably_damaging	0.92	neutral	0.27	neutral	2.16	deleterious	-4.15	neutral	-1.08	medium_impact	3.17	0.76	neutral	0.27	damaging	3.40	23.00	deleterious	0.42	0.5	0.34	neutral	0.79	disease	0.49	neutral	0.65	disease	3	0.93	neutral	0.18	neutral	1	deleterious	0.72	deleterious	-1.77	low_impact	-0.03	medium_impact	1.52	medium_impact	0.80	0.85	18.14	17.08	0.32	N	0.59	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14268	14268	G	C	MI.23346	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	406	136	R	G	Cgg/Ggg	0.86	0	0	probably_damaging	0.92	neutral	0.37	neutral	2.11	deleterious	-4.86	neutral	-2.05	low_impact	1.66	0.88	neutral	0.88	neutral	1.90	15.61	deleterious	0.35	0.5	0.48	neutral	0.68	disease	0.55	disease	0.5	disease	0	0.92	neutral	0.23	neutral	-2	neutral	0.72	deleterious	-1.77	low_impact	0.08	medium_impact	0.25	medium_impact	0.67	0.85	18.14	17.08	0.32	N	0.43	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14268	14268	G	A	MI.23347	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	406	136	R	W	Cgg/Tgg	0.86	0	0	probably_damaging	0.99	neutral	0.18	neutral	2.06	deleterious	-7.47	deleterious	-4.16	high_impact	3.52	0.59	damaging	0.11	damaging	3.68	23.30	deleterious	0.3	0.45	0.82	disease	0.9	disease	0.52	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.63	low_impact	-0.16	medium_impact	1.81	medium_impact	0.69	0.85	18.14	17.08	0.32	N	0.85	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14269	14269	A	C	MI.23348	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	405	135	I	M	atT/atG	0.17	0	0	possibly_damaging	0.81	neutral	0.39	neutral	2.23	deleterious	-4.19	neutral	-0.63	low_impact	1.38	0.88	neutral	0.92	neutral	1.39	12.72	neutral	0.44	0.55	0.15	neutral	0.33	neutral	0.28	neutral	0.45	neutral	1	0.82	neutral	0.29	neutral	-3	neutral	0.54	deleterious	-1.37	low_impact	0.1	medium_impact	0.02	medium_impact	0.90	0.95	17.7	17.51	0.41	N	0.34	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14269	14269	A	T	MI.23349	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	405	135	I	M	atT/atA	0.17	0	0	possibly_damaging	0.81	neutral	0.39	neutral	2.23	deleterious	-4.19	neutral	-0.63	low_impact	1.38	0.88	neutral	0.92	neutral	1.56	13.61	neutral	0.44	0.55	0.15	neutral	0.33	neutral	0.28	neutral	0.45	neutral	1	0.82	neutral	0.29	neutral	-3	neutral	0.54	deleterious	-1.37	low_impact	0.1	medium_impact	0.02	medium_impact	0.90	0.95	17.7	17.51	0.4	N	0.34	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6116	6116	A	C	MI.2335	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	213	71	M	I	atA/atC	7.53	1	0.01	probably_damaging	0.98	deleterious	0	neutral	2.8	neutral	-0.6	deleterious	-2.52	high_impact	3.78	0.53	damaging	0.1	damaging	3.34	22.90	deleterious	0.42	0.55	0.24	neutral	0.91	disease	0.61	disease	0.54	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	2.39	high_impact	0.61	0.9	1.95	6.89	0.5	P	0.87	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14270	14270	A	C	MI.23350	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	404	135	I	S	aTt/aGt	-2.12	0	0	possibly_damaging	0.66	neutral	0.45	neutral	2.24	deleterious	-4.68	deleterious	-3.46	low_impact	1.74	0.82	neutral	0.78	neutral	3.98	23.60	deleterious	0.34	0.5	0.38	neutral	0.64	disease	0.41	neutral	0.48	neutral	0	0.66	neutral	0.4	neutral	-3	neutral	0.51	deleterious	-1.06	low_impact	0.16	medium_impact	0.32	medium_impact	0.62	0.8	17.7	17.51	0.3	N	0.74	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14270	14270	A	T	MI.23351	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	404	135	I	N	aTt/aAt	-2.12	0	0	possibly_damaging	0.9	neutral	0.25	neutral	2.19	deleterious	-5.64	deleterious	-4.46	medium_impact	2.48	0.78	neutral	0.38	neutral	4.21	23.90	deleterious	0.31	0.45	0.55	disease	0.75	disease	0.64	disease	0.76	disease	5	0.93	neutral	0.18	neutral	0	NA	0.76	deleterious	-1.67	low_impact	-0.06	medium_impact	0.94	medium_impact	0.62	0.8	17.7	17.51	0.3	N	0.80	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14270	14270	A	G	MI.23352	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	404	135	I	T	aTt/aCt	-2.12	0	0	benign	0.37	neutral	0.28	neutral	2.24	deleterious	-4.26	deleterious	-2.8	medium_impact	2.48	0.84	neutral	0.56	neutral	3.29	22.80	deleterious	0.37	0.5	0.32	neutral	0.47	neutral	0.51	disease	0.52	disease	0	0.67	neutral	0.46	neutral	-3	neutral	0.41	neutral	-0.58	medium_impact	-0.02	medium_impact	0.94	medium_impact	0.68	0.85	17.7	17.51	0.44	N	0.59	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14271	14271	T	A	MI.23353	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	403	135	I	F	Att/Ttt	7.04	0.66	0	benign	0.03	neutral	0.73	neutral	2.27	deleterious	-4.31	neutral	1.05	neutral_impact	0.53	0.9	neutral	0.95	neutral	1.65	14.14	neutral	0.41	0.5	0.12	neutral	0.35	neutral	0.28	neutral	0.44	neutral	1	0.22	neutral	0.85	deleterious	-6	neutral	0.12	neutral	0.59	medium_impact	0.45	medium_impact	-0.7	medium_impact	0.84	0.9	17.7	17.51	0.44	N	0.18	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14271	14271	T	C	MI.23354	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	403	135	I	V	Att/Gtt	7.04	0.66	0	benign	0.01	neutral	0.53	neutral	2.46	neutral	-1.8	neutral	-0.56	neutral_impact	0.08	0.96	neutral	0.99	neutral	-1.58	0.00	neutral	0.48	0.55	0.17	neutral	0.08	neutral	0.25	neutral	0.23	neutral	5	0.46	neutral	0.76	deleterious	-6	neutral	0.09	neutral	1.03	medium_impact	0.24	medium_impact	-1.07	low_impact	0.73	0.85	17.7	17.51	0.55	P	0.54	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14271	14271	T	G	MI.23355	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	403	135	I	L	Att/Ctt	7.04	0.66	0	benign	0.12	neutral	1	neutral	2.39	neutral	-2.08	neutral	-0.43	low_impact	1.01	0.89	neutral	0.96	neutral	0.51	7.53	deleterious	0.35	0.5	0.14	neutral	0.28	neutral	0.24	neutral	0.42	neutral	2	0.12	neutral	0.94	deleterious	-6	neutral	0.17	neutral	0	medium_impact	1.87	high_impact	-0.29	medium_impact	0.75	0.85	17.7	17.51	0.48	N	0.29	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14272	14272	C	G	MI.23356	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	402	134	L	F	ttG/ttC	-1.89	0	0	probably_damaging	0.92	neutral	0.73	neutral	2.21	deleterious	-4.41	neutral	0.23	low_impact	1.31	0.91	neutral	0.96	neutral	1.27	12.11	neutral	0.44	0.55	0.14	neutral	0.28	neutral	0.42	neutral	0.43	neutral	1	0.91	neutral	0.41	neutral	-2	neutral	0.63	deleterious	-1.77	low_impact	0.45	medium_impact	-0.04	medium_impact	0.77	0.85	49.56	8.76	0.3	N	0.19	NA	NA	0.18	rs2853814	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14272	14272	C	A	MI.23357	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	402	134	L	F	ttG/ttT	-1.89	0	0	probably_damaging	0.92	neutral	0.73	neutral	2.21	deleterious	-4.41	neutral	0.23	low_impact	1.31	0.91	neutral	0.96	neutral	1.73	14.57	neutral	0.44	0.55	0.14	neutral	0.28	neutral	0.42	neutral	0.43	neutral	1	0.91	neutral	0.41	neutral	-2	neutral	0.63	deleterious	-1.77	low_impact	0.45	medium_impact	-0.04	medium_impact	0.77	0.85	49.56	8.76	0.38	N	0.19	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14273	14273	A	C	MI.23358	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	401	134	L	W	tTg/tGg	-7.4	0	0	probably_damaging	0.99	neutral	0.19	neutral	2.13	deleterious	-7.24	neutral	-2.23	medium_impact	3.08	0.78	neutral	0.49	neutral	1.70	14.43	neutral	0.25	0.45	0.72	disease	0.69	disease	0.68	disease	0.73	disease	5	0.99	deleterious	0.1	neutral	1	deleterious	0.77	deleterious	-2.63	low_impact	-0.14	medium_impact	1.44	medium_impact	0.69	0.85	49.56	8.76	0.36	N	0.54	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14273	14273	A	G	MI.23359	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	401	134	L	S	tTg/tCg	-7.4	0	0	probably_damaging	0.98	neutral	0.44	neutral	2.21	deleterious	-5.22	deleterious	-2.83	low_impact	1.94	0.81	neutral	0.83	neutral	2.87	21.70	deleterious	0.35	0.5	0.43	neutral	0.5	neutral	0.5	neutral	0.48	neutral	0	0.98	deleterious	0.23	neutral	-2	neutral	0.73	deleterious	-2.35	low_impact	0.15	medium_impact	0.49	medium_impact	0.79	0.85	49.56	8.76	0.33	N	0.63	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6117	6117	C	G	MI.2336	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	214	72	P	A	Ccc/Gcc	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-1.34	deleterious	-5.18	high_impact	4.63	0.68	neutral	0.12	damaging	2.99	22.20	deleterious	0.25	0.55	0.53	disease	0.79	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.18	high_impact	0.62	0.9	3.12	6.81	0.45	N	0.76	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14274	14274	A	T	MI.23360	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	400	134	L	M	Ttg/Atg	1.31	0	0	probably_damaging	0.99	neutral	0.25	neutral	2.2	deleterious	-4.39	neutral	-0.37	low_impact	1.52	0.89	neutral	0.91	neutral	2.71	20.90	deleterious	0.32	0.5	0.33	neutral	0.22	neutral	0.39	neutral	0.42	neutral	2	0.99	deleterious	0.13	neutral	-2	neutral	0.67	deleterious	-2.63	low_impact	-0.06	medium_impact	0.13	medium_impact	0.82	0.85	49.56	8.76	0.58	P	0.42	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14274	14274	A	C	MI.23361	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	400	134	L	V	Ttg/Gtg	1.31	0	0	probably_damaging	0.93	neutral	0.53	neutral	2.37	deleterious	-3.31	neutral	-0.37	low_impact	0.9	0.89	neutral	0.99	neutral	1.49	13.28	neutral	0.42	0.5	0.09	neutral	0.12	neutral	0.36	neutral	0.24	neutral	5	0.92	neutral	0.3	neutral	-2	neutral	0.60	deleterious	-1.83	low_impact	0.24	medium_impact	-0.39	medium_impact	0.80	0.85	49.56	8.76	0.42	N	0.19	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14276	14276	C	T	MI.23362	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	398	133	G	E	gGg/gAg	-7.17	0	0	possibly_damaging	0.51	neutral	0.43	neutral	2.27	deleterious	-5.32	deleterious	-4.66	low_impact	1.89	0.9	neutral	0.81	neutral	1.31	12.34	neutral	0.35	0.5	0.31	neutral	0.8	disease	0.44	neutral	0.59	disease	2	0.56	neutral	0.46	neutral	-3	neutral	0.63	deleterious	-0.81	medium_impact	0.14	medium_impact	0.44	medium_impact	0.70	0.85	50	8.72	0.38	N	0.96	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14276	14276	C	A	MI.23363	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	398	133	G	V	gGg/gTg	-7.17	0	0	probably_damaging	0.98	neutral	0.76	neutral	2.28	deleterious	-5.73	deleterious	-5.85	medium_impact	2.02	0.83	neutral	0.67	neutral	4.45	24.20	deleterious	0.29	0.45	0.34	neutral	0.8	disease	0.46	neutral	0.59	disease	2	0.98	deleterious	0.39	neutral	1	deleterious	0.77	deleterious	-2.35	low_impact	0.48	medium_impact	0.55	medium_impact	0.74	0.85	50	8.72	0.26	N	0.98	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14276	14276	C	G	MI.23364	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	398	133	G	A	gGg/gCg	-7.17	0	0	possibly_damaging	0.9	neutral	0.6	neutral	2.29	deleterious	-4.4	deleterious	-3.93	medium_impact	2.72	0.86	neutral	0.69	neutral	3.39	23.00	deleterious	0.42	0.55	0.16	neutral	0.67	disease	0.4	neutral	0.46	neutral	1	0.89	neutral	0.35	neutral	0	NA	0.69	deleterious	-1.67	low_impact	0.3	medium_impact	1.14	medium_impact	0.80	0.85	50	8.72	0.28	N	0.69	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14277	14277	C	G	MI.23365	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	397	133	G	R	Ggg/Cgg	0.63	0	0	probably_damaging	0.97	neutral	0.39	neutral	2.24	deleterious	-5.95	deleterious	-5.43	medium_impact	3.06	0.81	neutral	0.34	neutral	4.26	23.90	deleterious	0.31	0.45	0.39	neutral	0.85	disease	0.57	disease	0.78	disease	6	0.97	neutral	0.21	neutral	1	deleterious	0.80	deleterious	-2.18	low_impact	0.1	medium_impact	1.42	medium_impact	0.96	1	50	8.72	0.3	N	0.96	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14277	14277	C	A	MI.23366	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	397	133	G	W	Ggg/Tgg	0.63	0	0	probably_damaging	1	neutral	0.16	neutral	2.19	deleterious	-8.54	deleterious	-5.9	medium_impact	2.86	0.87	neutral	0.61	neutral	4.91	25.00	deleterious	0.22	0.45	0.8	disease	0.89	disease	0.46	neutral	0.78	disease	6	1	deleterious	0.08	neutral	1	deleterious	0.85	deleterious	-3.55	low_impact	-0.19	medium_impact	1.26	medium_impact	0.61	0.8	50	8.72	0.41	N	0.98	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14279	14279	G	C	MI.23367	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	395	132	S	W	tCa/tGa	-8.08	0	0.01	probably_damaging	0.91	neutral	0.18	neutral	2.21	deleterious	-7.43	neutral	-2.33	medium_impact	1.99	0.77	neutral	0.79	neutral	2.86	21.70	deleterious	0.27	0.45	0.79	disease	0.78	disease	0.4	neutral	0.68	disease	4	0.95	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-1.72	low_impact	-0.16	medium_impact	0.53	medium_impact	0.58	0.8	48.23	8.73	0.32	N	0.73	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14279	14279	G	A	MI.23368	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	395	132	S	L	tCa/tTa	-8.08	0	0.01	benign	0.01	neutral	0.65	neutral	2.39	deleterious	-4.34	neutral	-0.2	neutral_impact	0.76	0.91	neutral	0.96	neutral	0.38	6.47	deleterious	0.28	0.45	0.34	neutral	0.48	neutral	0.36	neutral	0.45	neutral	1	0.33	neutral	0.82	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	0.36	medium_impact	-0.5	medium_impact	0.82	0.85	48.23	8.73	0.42	N	0.58	NA	NA	0.18	rs869025187	Pathogenic	Leber's_optic_atrophy	76424	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	endometrial tumor	COSM6716818	CPD	1.34	G14279A	LHON	+	-	Reported	2	P	P	P	neutral
chrM	14280	14280	A	G	MI.23369	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	394	132	S	P	Tca/Cca	-0.06	0	0.01	benign	0.01	neutral	0.2	neutral	2.23	deleterious	-4.83	neutral	-1.86	low_impact	1.19	0.87	neutral	0.8	neutral	0.96	10.46	neutral	0.21	0.45	0.43	neutral	0.81	disease	0.38	neutral	0.63	disease	3	0.8	neutral	0.6	deleterious	-6	neutral	0.23	neutral	1.03	medium_impact	-0.13	medium_impact	-0.14	medium_impact	0.65	0.8	48.23	8.73	0.42	N	0.01	NA	NA	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6117	6117	C	A	MI.2337	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	214	72	P	T	Ccc/Acc	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-1.87	deleterious	-5.18	high_impact	4.29	0.63	neutral	0.08	damaging	3.57	23.10	deleterious	0.29	0.55	0.51	disease	0.87	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.86	high_impact	0.64	0.9	3.12	6.81	0.35	N	0.80	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14280	14280	A	C	MI.23370	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	394	132	S	A	Tca/Gca	-0.06	0	0.01	benign	0.01	neutral	0.5	neutral	2.3	neutral	-2.7	neutral	-0.33	low_impact	1.79	0.87	neutral	0.82	neutral	-0.32	0.60	neutral	0.35	0.5	0.23	neutral	0.44	neutral	0.32	neutral	0.46	neutral	1	0.49	neutral	0.75	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.21	medium_impact	0.36	medium_impact	0.71	0.85	48.23	8.73	0.35	N	0.30	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14280	14280	A	T	MI.23371	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	394	132	S	T	Tca/Aca	-0.06	0	0.01	benign	0.02	neutral	0.39	neutral	2.28	deleterious	-3.46	neutral	-0.22	low_impact	1.37	0.91	neutral	0.9	neutral	0.20	4.73	deleterious	0.25	0.45	0.28	neutral	0.35	neutral	0.36	neutral	0.44	neutral	1	0.59	neutral	0.69	deleterious	-6	neutral	0.12	neutral	0.75	medium_impact	0.1	medium_impact	0.01	medium_impact	0.71	0.85	48.23	8.73	0.45	N	0.33	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14282	14282	C	T	MI.23372	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	392	131	G	E	gGg/gAg	-4.87	0	0	possibly_damaging	0.61	neutral	0.3	neutral	2.34	deleterious	-5.32	neutral	-0.6	low_impact	1.05	0.87	neutral	0.86	neutral	0.56	7.88	deleterious	0.37	0.5	0.21	neutral	0.72	disease	0.34	neutral	0.55	disease	1	0.72	neutral	0.35	neutral	-3	neutral	0.60	deleterious	-0.97	medium_impact	0	medium_impact	-0.26	medium_impact	0.68	0.85	44.69	8.63	0.36	N	0.64	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14282	14282	C	G	MI.23373	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	392	131	G	A	gGg/gCg	-4.87	0	0	probably_damaging	0.93	neutral	0.53	neutral	2.36	deleterious	-4.4	neutral	-2.19	medium_impact	3.06	0.62	neutral	0.61	neutral	2.14	17.13	deleterious	0.37	0.5	0.32	neutral	0.74	disease	0.39	neutral	0.57	disease	1	0.92	neutral	0.3	neutral	1	deleterious	0.73	deleterious	-1.83	low_impact	0.24	medium_impact	1.42	medium_impact	0.73	0.85	44.69	8.63	0.32	N	0.59	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14282	14282	C	A	MI.23374	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	392	131	G	V	gGg/gTg	-4.87	0	0	probably_damaging	0.99	neutral	0.53	neutral	2.3	deleterious	-5.73	deleterious	-3.77	medium_impact	2.51	0.74	neutral	0.65	neutral	3.33	22.90	deleterious	0.28	0.45	0.55	disease	0.85	disease	0.4	neutral	0.6	disease	2	0.99	deleterious	0.27	neutral	1	deleterious	0.81	deleterious	-2.63	low_impact	0.24	medium_impact	0.96	medium_impact	0.73	0.85	44.69	8.63	0.26	N	0.85	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14283	14283	C	G	MI.23375	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	391	131	G	R	Ggg/Cgg	-0.06	0	0	probably_damaging	0.98	neutral	0.36	neutral	2.3	deleterious	-5.95	deleterious	-2.75	medium_impact	3.06	0.58	damaging	0.36	neutral	3.10	22.50	deleterious	0.27	0.45	0.48	neutral	0.87	disease	0.55	disease	0.76	disease	5	0.98	deleterious	0.19	neutral	1	deleterious	0.81	deleterious	-2.35	low_impact	0.07	medium_impact	1.42	medium_impact	0.89	0.9	44.69	8.63	0.37	N	0.81	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14283	14283	C	A	MI.23376	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	391	131	G	W	Ggg/Tgg	-0.06	0	0	probably_damaging	1	neutral	0.18	neutral	2.29	deleterious	-8.54	deleterious	-4.13	medium_impact	2.86	0.68	neutral	0.66	neutral	5.01	25.10	deleterious	0.23	0.45	0.88	disease	0.9	disease	0.6	disease	0.78	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.85	deleterious	-3.55	low_impact	-0.16	medium_impact	1.26	medium_impact	0.61	0.8	44.69	8.63	0.33	N	0.88	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14284	14284	C	G	MI.23377	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	390	130	E	D	gaG/gaC	1.77	0	0	benign	0.36	neutral	0.35	neutral	2.27	deleterious	-3.1	neutral	-0.28	low_impact	1.58	0.89	neutral	0.9	neutral	-0.02	2.38	deleterious	0.31	0.45	0.12	neutral	0.27	neutral	0.27	neutral	0.43	neutral	1	0.58	neutral	0.5	deleterious	-6	neutral	0.30	neutral	-0.57	medium_impact	0.06	medium_impact	0.18	medium_impact	0.84	0.9	49.12	8.75	0.52	N	0.26	NA	NA	0.17	rs28357673	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14285	14285	T	A	MI.23378	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	389	130	E	V	gAg/gTg	-5.79	0	0	probably_damaging	0.99	neutral	0.57	neutral	2.21	deleterious	-4.86	deleterious	-4.32	low_impact	1.68	0.86	neutral	0.73	neutral	3.33	22.90	deleterious	0.23	0.45	0.47	neutral	0.55	disease	0.4	neutral	0.47	neutral	1	0.99	deleterious	0.29	neutral	-2	neutral	0.75	deleterious	-2.63	low_impact	0.27	medium_impact	0.27	medium_impact	0.73	0.85	49.12	8.75	0.25	N	0.77	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14285	14285	T	G	MI.23379	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	389	130	E	A	gAg/gCg	-5.79	0	0	probably_damaging	0.96	neutral	0.68	neutral	2.26	deleterious	-3.9	deleterious	-2.6	medium_impact	2.32	0.8	neutral	0.44	neutral	2.37	18.63	deleterious	0.28	0.45	0.25	neutral	0.49	neutral	0.43	neutral	0.46	neutral	1	0.95	neutral	0.36	neutral	1	deleterious	0.69	deleterious	-2.06	low_impact	0.39	medium_impact	0.8	medium_impact	0.70	0.85	49.12	8.75	0.21	N	0.59	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6117	6117	C	T	MI.2338	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	214	72	P	S	Ccc/Tcc	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	2.75	neutral	-2.32	deleterious	-5.18	high_impact	4.63	0.57	damaging	0.11	damaging	3.78	23.40	deleterious	0.35	0.55	0.66	disease	0.84	disease	0.68	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.18	high_impact	0.28	0.9	3.12	6.81	0.44	N	0.85	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14285	14285	T	C	MI.23380	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	389	130	E	G	gAg/gGg	-5.79	0	0	probably_damaging	0.98	neutral	0.42	neutral	2.31	deleterious	-4.34	neutral	-0.67	low_impact	0.88	0.88	neutral	0.95	neutral	2.19	17.45	deleterious	0.26	0.45	0.11	neutral	0.2	neutral	0.42	neutral	0.37	neutral	3	0.97	neutral	0.22	neutral	-2	neutral	0.63	deleterious	-2.35	low_impact	0.13	medium_impact	-0.4	medium_impact	0.63	0.8	49.12	8.75	0.37	N	0.23	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14286	14286	C	G	MI.23381	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	388	130	E	Q	Gag/Cag	-0.98	0	0	probably_damaging	0.98	neutral	0.43	neutral	2.25	deleterious	-4.06	neutral	-1.56	medium_impact	2.43	0.8	neutral	0.35	neutral	2.13	17.04	deleterious	0.37	0.5	0.27	neutral	0.27	neutral	0.38	neutral	0.44	neutral	1	0.98	deleterious	0.23	neutral	1	deleterious	0.67	deleterious	-2.35	low_impact	0.14	medium_impact	0.9	medium_impact	0.80	0.85	49.12	8.75	0.38	N	0.73	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14286	14286	C	T	MI.23382	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	388	130	E	K	Gag/Aag	-0.98	0	0	probably_damaging	0.96	neutral	0.5	neutral	2.29	deleterious	-3.58	neutral	-1.87	low_impact	1.58	0.77	neutral	0.29	neutral	2.83	21.50	deleterious	0.31	0.45	0.24	neutral	0.43	neutral	0.43	neutral	0.45	neutral	1	0.95	neutral	0.27	neutral	-2	neutral	0.70	deleterious	-2.06	low_impact	0.21	medium_impact	0.18	medium_impact	0.86	0.9	49.12	8.75	0.27	N	0.76	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14288	14288	C	G	MI.23383	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	386	129	G	A	gGa/gCa	-12.67	0	0	probably_damaging	0.96	neutral	0.51	neutral	2.32	deleterious	-4.4	neutral	-0.87	low_impact	1.8	0.86	neutral	0.77	neutral	1.03	10.82	neutral	0.4	0.5	0.14	neutral	0.48	neutral	0.33	neutral	0.43	neutral	1	0.96	neutral	0.28	neutral	-2	neutral	0.67	deleterious	-2.06	low_impact	0.22	medium_impact	0.37	medium_impact	0.78	0.85	49.12	8.65	0.33	N	0.40	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14288	14288	C	T	MI.23384	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	386	129	G	E	gGa/gAa	-12.67	0	0	probably_damaging	0.99	neutral	0.3	neutral	2.3	deleterious	-5.32	neutral	-1.93	low_impact	1.88	0.87	neutral	0.74	neutral	0.00	2.55	deleterious	0.24	0.45	0.21	neutral	0.62	disease	0.34	neutral	0.44	neutral	1	0.99	deleterious	0.16	neutral	-2	neutral	0.72	deleterious	-2.63	low_impact	0	medium_impact	0.44	medium_impact	0.76	0.85	49.12	8.65	0.39	N	0.69	NA	NA	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14288	14288	C	A	MI.23385	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	386	129	G	V	gGa/gTa	-12.67	0	0	probably_damaging	0.99	neutral	0.51	neutral	2.39	deleterious	-5.73	neutral	-1.56	low_impact	1.17	0.82	neutral	0.91	neutral	2.48	19.32	deleterious	0.26	0.45	0.15	neutral	0.59	disease	0.32	neutral	0.43	neutral	1	0.99	deleterious	0.26	neutral	-2	neutral	0.68	deleterious	-2.63	low_impact	0.22	medium_impact	-0.16	medium_impact	0.70	0.85	49.12	8.65	0.29	N	0.34	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14289	14289	C	G	MI.23386	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	385	129	G	R	Gga/Cga	-2.81	0	0	probably_damaging	1	neutral	0.35	neutral	2.29	deleterious	-5.95	deleterious	-2.69	medium_impact	2.73	0.73	neutral	0.19	damaging	2.32	18.32	deleterious	0.27	0.45	0.26	neutral	0.68	disease	0.52	disease	0.63	disease	3	1	deleterious	0.18	neutral	1	deleterious	0.72	deleterious	-3.55	low_impact	0.06	medium_impact	1.15	medium_impact	0.93	0.95	49.12	8.65	0.32	N	0.68	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14289	14289	C	A	MI.23387	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	385	129	G	W	Gga/Tga	-2.81	0	0	probably_damaging	1	neutral	0.19	neutral	2.26	deleterious	-8.54	deleterious	-3.42	medium_impact	2.38	0.8	neutral	0.26	damaging	3.84	23.40	deleterious	0.2	0.45	0.65	disease	0.79	disease	0.54	disease	0.74	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	-0.14	medium_impact	0.85	medium_impact	0.52	0.8	49.12	8.65	0.3	N	0.77	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14290	14290	T	A	MI.23388	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	384	128	E	D	gaA/gaT	-0.98	0	0	probably_damaging	1	neutral	0.22	neutral	2.3	deleterious	-3.1	neutral	1.24	low_impact	1.1	0.85	neutral	0.98	neutral	-0.42	0.35	neutral	0.38	0.5	0.09	neutral	0.22	neutral	0.24	neutral	0.38	neutral	2	1	deleterious	0.11	neutral	-2	neutral	0.64	deleterious	-3.55	low_impact	-0.1	medium_impact	-0.22	medium_impact	0.83	0.9	19.91	15.56	0.45	N	0.08	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14290	14290	T	G	MI.23389	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	384	128	E	D	gaA/gaC	-0.98	0	0	probably_damaging	1	neutral	0.22	neutral	2.3	deleterious	-3.1	neutral	1.24	low_impact	1.1	0.85	neutral	0.98	neutral	-0.53	0.19	neutral	0.38	0.5	0.09	neutral	0.22	neutral	0.24	neutral	0.38	neutral	2	1	deleterious	0.11	neutral	-2	neutral	0.64	deleterious	-3.55	low_impact	-0.1	medium_impact	-0.22	medium_impact	0.83	0.9	19.91	15.56	0.48	N	0.08	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6118	6118	C	T	MI.2339	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	215	72	P	L	cCc/cTc	4.52	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-2.68	deleterious	-6.48	high_impact	4.38	0.61	neutral	0.08	damaging	4.21	23.90	deleterious	0.25	0.55	0.76	disease	0.89	disease	0.66	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.65	0.9	3.12	6.81	0.5	P	0.87	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14291	14291	T	G	MI.23390	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	383	128	E	A	gAa/gCa	-1.89	0	0	probably_damaging	1	neutral	0.51	neutral	2.3	deleterious	-3.9	deleterious	-2.96	medium_impact	2.23	0.78	neutral	0.44	neutral	4.05	23.70	deleterious	0.29	0.45	0.3	neutral	0.77	disease	0.5	neutral	0.66	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	0.22	medium_impact	0.73	medium_impact	0.77	0.85	19.91	15.56	0.24	N	0.70	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14291	14291	T	C	MI.23391	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	383	128	E	G	gAa/gGa	-1.89	0	0	probably_damaging	1	neutral	0.35	neutral	2.27	deleterious	-4.34	neutral	-1.98	low_impact	1.48	0.85	neutral	0.95	neutral	2.72	20.90	deleterious	0.34	0.5	0.35	neutral	0.61	disease	0.44	neutral	0.47	neutral	1	1	deleterious	0.18	neutral	-2	neutral	0.72	deleterious	-3.55	low_impact	0.06	medium_impact	0.1	medium_impact	0.76	0.85	19.91	15.56	0.37	N	0.71	NA	NA	0.27	.	.	.	.	.	.	COSM1155551	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14291	14291	T	A	MI.23392	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	383	128	E	V	gAa/gTa	-1.89	0	0	probably_damaging	1	neutral	0.51	neutral	2.27	deleterious	-4.86	deleterious	-4.25	medium_impact	2.08	0.76	neutral	0.33	neutral	4.58	24.40	deleterious	0.24	0.45	0.51	disease	0.84	disease	0.4	neutral	0.72	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	0.22	medium_impact	0.6	medium_impact	0.82	0.85	19.91	15.56	0.32	N	0.83	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14292	14292	C	T	MI.23393	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	382	128	E	K	Gaa/Aaa	0.63	0.07	0	probably_damaging	1	neutral	0.3	neutral	2.31	deleterious	-3.58	neutral	-2.32	medium_impact	2.73	0.79	neutral	0.21	damaging	4.72	24.60	deleterious	0.42	0.55	0.27	neutral	0.83	disease	0.52	disease	0.75	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.77	deleterious	-3.55	low_impact	0	medium_impact	1.15	medium_impact	0.81	0.85	19.91	15.56	0.37	N	0.82	NA	NA	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14292	14292	C	G	MI.23394	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	382	128	E	Q	Gaa/Caa	0.63	0.07	0	probably_damaging	1	neutral	0.3	neutral	2.25	deleterious	-4.06	neutral	-1.62	medium_impact	3.27	0.76	neutral	0.36	neutral	3.62	23.20	deleterious	0.44	0.55	0.29	neutral	0.6	disease	0.47	neutral	0.5	disease	0	1	deleterious	0.15	neutral	1	deleterious	0.71	deleterious	-3.55	low_impact	0	medium_impact	1.6	medium_impact	0.82	0.85	19.91	15.56	0.46	N	0.85	NA	NA	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14294	14294	T	C	MI.23395	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	380	127	Y	C	tAt/tGt	1.54	0.09	0	probably_damaging	0.96	neutral	0.18	neutral	2.26	deleterious	-6.77	deleterious	-6.53	low_impact	1.47	0.87	neutral	0.72	neutral	2.25	17.85	deleterious	0.38	0.5	0.6	disease	0.78	disease	0.38	neutral	0.63	disease	3	0.97	neutral	0.11	neutral	-2	neutral	0.77	deleterious	-2.06	low_impact	-0.16	medium_impact	0.09	medium_impact	0.25	0.8	50.44	8.73	0.45	N	0.95	NA	NA	0.54	.	.	.	.	.	.	COSM1138256	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14294	14294	T	A	MI.23396	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	380	127	Y	F	tAt/tTt	1.54	0.09	0	benign	0.02	neutral	0.71	neutral	2.32	neutral	-2.93	neutral	-1.42	neutral_impact	-0.01	0.96	neutral	0.96	neutral	0.16	4.26	deleterious	0.52	0.6	0.29	neutral	0.29	neutral	0.26	neutral	0.44	neutral	1	0.26	neutral	0.85	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.42	medium_impact	-1.15	low_impact	0.52	0.8	50.44	8.73	0.4	N	0.41	NA	NA	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14294	14294	T	G	MI.23397	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	380	127	Y	S	tAt/tCt	1.54	0.09	0	possibly_damaging	0.76	neutral	0.45	neutral	2.39	deleterious	-4.84	deleterious	-6.76	low_impact	1.32	0.86	neutral	0.81	neutral	3.72	23.30	deleterious	0.33	0.5	0.29	neutral	0.59	disease	0.37	neutral	0.46	neutral	1	0.75	neutral	0.35	neutral	-3	neutral	0.59	deleterious	-1.26	low_impact	0.16	medium_impact	-0.03	medium_impact	0.52	0.8	50.44	8.73	0.38	N	0.93	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14295	14295	A	T	MI.23398	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	379	127	Y	N	Tat/Aat	-1.21	0	0	possibly_damaging	0.79	neutral	0.35	neutral	2.43	deleterious	-5.32	deleterious	-7.19	low_impact	1.55	0.78	neutral	0.65	neutral	3.45	23.00	deleterious	0.39	0.5	0.37	neutral	0.7	disease	0.46	neutral	0.54	disease	1	0.81	neutral	0.28	neutral	-3	neutral	0.67	deleterious	-1.32	low_impact	0.06	medium_impact	0.16	medium_impact	0.44	0.8	50.44	8.73	0.33	N	0.94	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14295	14295	A	G	MI.23399	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	379	127	Y	H	Tat/Cat	-1.21	0	0	benign	0.06	neutral	0.54	neutral	2.3	deleterious	-5.03	deleterious	-4.19	low_impact	1.9	0.84	neutral	0.61	neutral	2.33	18.35	deleterious	0.44	0.55	0.45	neutral	0.59	disease	0.45	neutral	0.5	neutral	0	0.4	neutral	0.74	deleterious	-6	neutral	0.24	neutral	0.3	medium_impact	0.25	medium_impact	0.45	medium_impact	0.56	0.8	50.44	8.73	0.3	N	0.87	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8636	8636	T	C	MI.234	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	110	37	L	P	cTc/cCc	0.59	0.38	0	probably_damaging	0.94	deleterious	0.03	neutral	4.3	deleterious	-3.46	deleterious	-4.25	medium_impact	3.21	0.92	neutral	0.58	neutral	3.66	23.20	deleterious	0.3	0.65	0.88	disease	0.84	disease	0.7	disease	0.81	disease	6	0.99	deleterious	0.05	neutral	5	deleterious	0.84	deleterious	-1.89	low_impact	-0.56	medium_impact	1.65	medium_impact	0.48	0.9	20.35	20.89	0.37	N	0.61	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6118	6118	C	G	MI.2340	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	215	72	P	R	cCc/cGc	4.52	1	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.81	deleterious	-5.83	high_impact	5.18	0.6	damaging	0.07	damaging	3.47	23.00	deleterious	0.17	0.55	0.87	disease	0.94	disease	0.8	disease	0.91	disease	8	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.54	0.9	3.12	6.81	0.68	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14295	14295	A	C	MI.23400	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	379	127	Y	D	Tat/Gat	-1.21	0	0	possibly_damaging	0.84	neutral	0.25	neutral	2.36	deleterious	-5.53	deleterious	-7.82	low_impact	0.86	0.75	neutral	0.75	neutral	3.42	23.00	deleterious	0.31	0.45	0.41	neutral	0.66	disease	0.51	disease	0.48	neutral	0	0.88	neutral	0.21	neutral	-3	neutral	0.71	deleterious	-1.46	low_impact	-0.06	medium_impact	-0.42	medium_impact	0.52	0.8	50.44	8.73	0.36	N	0.93	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14296	14296	A	C	MI.23401	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	378	126	I	M	atT/atG	2.23	0	0	probably_damaging	0.94	neutral	0.3	neutral	2.2	deleterious	-4.19	neutral	-1.69	low_impact	1.59	0.88	neutral	0.96	neutral	1.91	15.63	deleterious	0.45	0.55	0.19	neutral	0.36	neutral	0.3	neutral	0.46	neutral	1	0.95	neutral	0.18	neutral	-2	neutral	0.63	deleterious	-1.89	low_impact	0	medium_impact	0.19	medium_impact	0.95	0.95	50.44	8.66	0.47	N	0.36	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14296	14296	A	T	MI.23402	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	378	126	I	M	atT/atA	2.23	0	0	probably_damaging	0.94	neutral	0.3	neutral	2.2	deleterious	-4.19	neutral	-1.69	low_impact	1.59	0.88	neutral	0.96	neutral	2.02	16.33	deleterious	0.45	0.55	0.19	neutral	0.36	neutral	0.3	neutral	0.46	neutral	1	0.95	neutral	0.18	neutral	-2	neutral	0.63	deleterious	-1.89	low_impact	0	medium_impact	0.19	medium_impact	0.95	0.95	50.44	8.66	0.46	N	0.36	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14297	14297	A	G	MI.23403	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	377	126	I	T	aTt/aCt	-0.75	0	0	possibly_damaging	0.79	neutral	0.4	neutral	2.19	deleterious	-4.26	deleterious	-2.96	low_impact	1.77	0.87	neutral	0.77	neutral	3.16	22.60	deleterious	0.44	0.55	0.18	neutral	0.53	disease	0.4	neutral	0.43	neutral	1	0.8	neutral	0.31	neutral	-3	neutral	0.56	deleterious	-1.32	low_impact	0.11	medium_impact	0.34	medium_impact	0.84	0.9	50.44	8.66	0.36	N	0.91	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14297	14297	A	C	MI.23404	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	377	126	I	S	aTt/aGt	-0.75	0	0	probably_damaging	0.92	neutral	0.5	neutral	2.16	deleterious	-4.68	deleterious	-4.09	low_impact	1.62	0.74	neutral	0.73	neutral	3.81	23.40	deleterious	0.35	0.5	0.27	neutral	0.69	disease	0.31	neutral	0.53	disease	1	0.91	neutral	0.29	neutral	-2	neutral	0.68	deleterious	-1.77	low_impact	0.21	medium_impact	0.22	medium_impact	0.75	0.85	50.44	8.66	0.34	N	0.86	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14297	14297	A	T	MI.23405	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	377	126	I	N	aTt/aAt	-0.75	0	0	probably_damaging	0.97	neutral	0.38	neutral	2.18	deleterious	-5.64	deleterious	-5	medium_impact	2.28	0.74	neutral	0.63	neutral	3.88	23.50	deleterious	0.32	0.5	0.24	neutral	0.77	disease	0.45	neutral	0.61	disease	2	0.97	neutral	0.21	neutral	1	deleterious	0.71	deleterious	-2.18	low_impact	0.09	medium_impact	0.77	medium_impact	0.72	0.85	50.44	8.66	0.41	N	0.97	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14298	14298	T	C	MI.23406	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	376	126	I	V	Att/Gtt	2.23	0	0	benign	0.03	neutral	0.7	neutral	2.33	neutral	-1.8	neutral	-0.1	neutral_impact	0.24	0.94	neutral	0.98	neutral	-1.08	0.01	neutral	0.5	0.6	0.15	neutral	0.11	neutral	0.26	neutral	0.22	neutral	6	0.24	neutral	0.84	deleterious	-6	neutral	0.10	neutral	0.59	medium_impact	0.41	medium_impact	-0.94	medium_impact	0.73	0.85	50.44	8.66	0.45	N	0.52	NA	NA	0.16	rs879200945	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14298	14298	T	G	MI.23407	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	376	126	I	L	Att/Ctt	2.23	0	0	possibly_damaging	0.45	neutral	0.85	neutral	2.44	neutral	-2.08	neutral	-1.36	low_impact	1.2	0.87	neutral	0.88	neutral	1.23	11.89	neutral	0.44	0.55	0.16	neutral	0.43	neutral	0.37	neutral	0.44	neutral	1	0.34	neutral	0.7	deleterious	-3	neutral	0.28	neutral	-0.72	medium_impact	0.63	medium_impact	-0.14	medium_impact	0.81	0.85	50.44	8.66	0.3	N	0.65	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14298	14298	T	A	MI.23408	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	376	126	I	F	Att/Ttt	2.23	0	0	probably_damaging	0.94	neutral	0.86	neutral	2.24	deleterious	-4.31	deleterious	-3.26	low_impact	1.56	0.76	neutral	0.77	neutral	4.21	23.90	deleterious	0.38	0.5	0.32	neutral	0.68	disease	0.3	neutral	0.5	neutral	0	0.93	neutral	0.46	neutral	-2	neutral	0.66	deleterious	-1.89	low_impact	0.64	medium_impact	0.17	medium_impact	0.83	0.85	50.44	8.66	0.25	N	0.84	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14299	14299	T	A	MI.23409	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	375	125	M	I	atA/atT	-3.27	0	0	benign	0.06	neutral	0.48	neutral	2.47	neutral	-2.28	neutral	0.72	low_impact	1.26	0.9	neutral	0.92	neutral	1.20	11.76	neutral	0.54	0.6	0.11	neutral	0.52	disease	0.36	neutral	0.43	neutral	1	0.47	neutral	0.71	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	0.19	medium_impact	-0.08	medium_impact	0.68	0.85	48.23	8.39	0.37	N	0.16	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6118	6118	C	A	MI.2341	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	215	72	P	H	cCc/cAc	4.52	1	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-3.88	deleterious	-5.83	high_impact	5.18	0.62	neutral	0.07	damaging	4.00	23.60	deleterious	0.2	0.55	0.92	disease	0.89	disease	0.78	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.51	0.9	3.12	6.81	0.71	P	0.81	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14299	14299	T	G	MI.23410	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	375	125	M	I	atA/atC	-3.27	0	0	benign	0.06	neutral	0.48	neutral	2.47	neutral	-2.28	neutral	0.72	low_impact	1.26	0.9	neutral	0.92	neutral	0.87	9.91	deleterious	0.54	0.6	0.11	neutral	0.52	disease	0.36	neutral	0.43	neutral	1	0.47	neutral	0.71	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	0.19	medium_impact	-0.08	medium_impact	0.68	0.85	48.23	8.39	0.44	N	0.16	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14300	14300	A	G	MI.23411	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	374	125	M	T	aTa/aCa	-5.79	0	0	benign	0.14	neutral	0.44	neutral	2.35	deleterious	-3.69	neutral	-1.63	low_impact	1.26	0.85	neutral	0.85	neutral	1.38	12.69	neutral	0.44	0.55	0.27	neutral	0.53	disease	0.46	neutral	0.44	neutral	1	0.48	neutral	0.65	deleterious	-6	neutral	0.25	neutral	-0.07	medium_impact	0.15	medium_impact	-0.08	medium_impact	0.61	0.8	48.23	8.39	0.39	N	0.44	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14300	14300	A	T	MI.23412	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	374	125	M	K	aTa/aAa	-5.79	0	0	benign	0.34	neutral	0.33	neutral	2.36	deleterious	-3.95	deleterious	-3.04	medium_impact	2.5	0.77	neutral	0.7	neutral	1.98	16.08	deleterious	0.29	0.45	0.41	neutral	0.75	disease	0.47	neutral	0.58	disease	2	0.61	neutral	0.5	deleterious	-3	neutral	0.48	deleterious	-0.53	medium_impact	0.04	medium_impact	0.95	medium_impact	0.70	0.85	48.23	8.39	0.44	N	0.83	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14301	14301	T	G	MI.23413	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	373	125	M	L	Ata/Cta	0.17	0	0	benign	0.04	neutral	0.77	neutral	2.36	neutral	-1.28	neutral	-0.26	low_impact	0.9	0.9	neutral	0.95	neutral	0.41	6.69	deleterious	0.52	0.6	0.08	neutral	0.44	neutral	0.34	neutral	0.41	neutral	2	0.16	neutral	0.87	deleterious	-6	neutral	0.13	neutral	0.47	medium_impact	0.5	medium_impact	-0.39	medium_impact	0.70	0.85	48.23	8.39	0.36	N	0.27	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14301	14301	T	C	MI.23414	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	373	125	M	V	Ata/Gta	0.17	0	0	benign	0	neutral	0.62	neutral	2.33	neutral	-2.31	neutral	1.27	neutral_impact	-0.68	0.97	neutral	0.99	neutral	-2.11	0.00	neutral	0.65	0.7	0.08	neutral	0.22	neutral	0.32	neutral	0.38	neutral	2	0.37	neutral	0.81	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.32	medium_impact	-1.71	low_impact	0.76	0.85	48.23	8.39	0.4	N	0.08	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14301	14301	T	A	MI.23415	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	373	125	M	L	Ata/Tta	0.17	0	0	benign	0.04	neutral	0.77	neutral	2.36	neutral	-1.28	neutral	-0.26	low_impact	0.9	0.9	neutral	0.95	neutral	0.52	7.55	deleterious	0.52	0.6	0.08	neutral	0.44	neutral	0.34	neutral	0.41	neutral	2	0.16	neutral	0.87	deleterious	-6	neutral	0.13	neutral	0.47	medium_impact	0.5	medium_impact	-0.39	medium_impact	0.70	0.85	48.23	8.39	0.4	N	0.27	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14302	14302	T	A	MI.23416	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	372	124	W	C	tgA/tgT	-2.58	0	0	probably_damaging	1	neutral	0.18	neutral	2.3	deleterious	-7.1	deleterious	-12.53	medium_impact	3.19	0.75	neutral	0.36	neutral	4.63	24.50	deleterious	0.38	0.5	0.83	disease	0.94	disease	0.65	disease	0.7	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	-0.16	medium_impact	1.53	medium_impact	0.51	0.8	19.91	7.92	0.45	N	0.96	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14302	14302	T	G	MI.23417	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	372	124	W	C	tgA/tgC	-2.58	0	0	probably_damaging	1	neutral	0.18	neutral	2.3	deleterious	-7.1	deleterious	-12.53	medium_impact	3.19	0.75	neutral	0.36	neutral	4.36	24.10	deleterious	0.38	0.5	0.83	disease	0.94	disease	0.65	disease	0.7	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	-0.16	medium_impact	1.53	medium_impact	0.51	0.8	19.91	7.92	0.37	N	0.96	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14303	14303	C	A	MI.23418	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	371	124	W	L	tGa/tTa	-5.79	0	0	probably_damaging	1	neutral	0.72	neutral	2.45	deleterious	-4.25	deleterious	-12.33	medium_impact	2.18	0.86	neutral	0.67	neutral	4.65	24.50	deleterious	0.34	0.5	0.58	disease	0.84	disease	0.62	disease	0.61	disease	2	1	deleterious	0.36	neutral	1	deleterious	0.83	deleterious	-3.55	low_impact	0.43	medium_impact	0.69	medium_impact	0.45	0.8	19.91	7.92	0.3	N	0.96	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14303	14303	C	G	MI.23419	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	371	124	W	S	tGa/tCa	-5.79	0	0	probably_damaging	1	neutral	0.47	neutral	2.39	deleterious	-5.45	deleterious	-13.37	low_impact	1.87	0.8	neutral	0.32	neutral	4.26	23.90	deleterious	0.34	0.5	0.58	disease	0.93	disease	0.63	disease	0.62	disease	2	1	deleterious	0.24	neutral	-2	neutral	0.86	deleterious	-3.55	low_impact	0.18	medium_impact	0.43	medium_impact	0.55	0.8	19.91	7.92	0.33	N	0.95	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6120	6120	A	G	MI.2342	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	217	73	I	V	Atc/Gtc	-12.6	0	0	probably_damaging	0.95	neutral	0.5	neutral	2.81	neutral	0.05	neutral	-0.5	low_impact	1.1	0.68	neutral	0.74	neutral	1.54	13.54	neutral	0.57	0.6	0.29	neutral	0.31	neutral	0.27	neutral	0.45	neutral	1	0.95	neutral	0.28	neutral	-2	neutral	0.61	deleterious	-1.96	low_impact	0.19	medium_impact	-0.08	medium_impact	0.54	0.9	5.65	37.31	0.42	N	0.25	polymorphism	1	0.02	rs878853023	Uncertain_significance	not_provided	237064	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14304	14304	A	G	MI.23420	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	370	124	W	R	Tga/Cga	-0.29	0	0	probably_damaging	1	neutral	0.35	neutral	2.31	deleterious	-5.59	deleterious	-13.51	high_impact	3.54	0.76	neutral	0.12	damaging	3.78	23.40	deleterious	0.42	0.55	0.67	disease	0.92	disease	0.74	disease	0.82	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0.06	medium_impact	1.83	medium_impact	0.53	0.8	19.91	7.92	0.41	N	0.94	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14304	14304	A	C	MI.23421	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	370	124	W	G	Tga/Gga	-0.29	0	0	probably_damaging	1	neutral	0.36	neutral	2.51	deleterious	-5.63	deleterious	-12.48	medium_impact	2.09	0.8	neutral	0.46	neutral	3.67	23.30	deleterious	0.37	0.5	0.3	neutral	0.88	disease	0.64	disease	0.61	disease	2	1	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	0.07	medium_impact	0.61	medium_impact	0.63	0.8	19.91	7.92	0.34	N	0.91	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14306	14306	C	T	MI.23422	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	368	123	S	N	aGc/aAc	-0.29	0	0	benign	0.01	neutral	0.37	neutral	2.27	deleterious	-4.18	neutral	0.83	low_impact	1.63	0.89	neutral	0.88	neutral	0.66	8.53	deleterious	0.55	0.6	0.27	neutral	0.51	disease	0.39	neutral	0.48	neutral	0	0.62	neutral	0.68	deleterious	-6	neutral	0.17	neutral	1.03	medium_impact	0.08	medium_impact	0.23	medium_impact	0.70	0.85	24.34	21.11	0.5	N	0.44	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14306	14306	C	G	MI.23423	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	368	123	S	T	aGc/aCc	-0.29	0	0	benign	0.22	neutral	0.41	neutral	2.21	deleterious	-3.46	neutral	-1.14	medium_impact	2.06	0.79	neutral	0.71	neutral	1.99	16.13	deleterious	0.26	0.45	0.26	neutral	0.48	neutral	0.44	neutral	0.47	neutral	1	0.5	neutral	0.6	deleterious	-3	neutral	0.36	neutral	-0.29	medium_impact	0.12	medium_impact	0.59	medium_impact	0.84	0.9	24.34	21.11	0.41	N	0.41	NA	NA	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14306	14306	C	A	MI.23424	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	368	123	S	I	aGc/aTc	-0.29	0	0	possibly_damaging	0.71	neutral	0.45	neutral	2.17	deleterious	-4.77	deleterious	-2.97	medium_impact	2.25	0.77	neutral	0.61	neutral	4.59	24.40	deleterious	0.35	0.5	0.43	neutral	0.79	disease	0.48	neutral	0.67	disease	3	0.7	neutral	0.37	neutral	0	NA	0.66	deleterious	-1.15	low_impact	0.16	medium_impact	0.75	medium_impact	0.89	0.9	24.34	21.11	0.38	N	0.83	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14307	14307	T	C	MI.23425	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	367	123	S	G	Agc/Ggc	-2.35	0	0	benign	0.01	neutral	0.39	neutral	2.19	deleterious	-3.71	neutral	-0.94	neutral_impact	0.76	0.93	neutral	0.91	neutral	0.18	4.42	deleterious	0.3	0.45	0.33	neutral	0.36	neutral	0.35	neutral	0.46	neutral	1	0.6	neutral	0.69	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.1	medium_impact	-0.5	medium_impact	0.84	0.9	24.34	21.11	0.5	N	0.42	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14307	14307	T	A	MI.23426	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	367	123	S	C	Agc/Tgc	-2.35	0	0	probably_damaging	0.91	neutral	0.17	neutral	2.14	deleterious	-5.59	deleterious	-3.12	medium_impact	2.06	0.79	neutral	0.64	neutral	3.69	23.30	deleterious	0.3	0.45	0.66	disease	0.73	disease	0.39	neutral	0.62	disease	2	0.95	neutral	0.13	neutral	1	deleterious	0.75	deleterious	-1.72	low_impact	-0.18	medium_impact	0.59	medium_impact	0.87	0.9	24.34	21.11	0.42	N	0.69	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14307	14307	T	G	MI.23427	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	367	123	S	R	Agc/Cgc	-2.35	0	0	possibly_damaging	0.52	neutral	0.35	neutral	2.18	deleterious	-4.42	neutral	-1.8	medium_impact	2.6	0.75	neutral	0.45	neutral	3.96	23.60	deleterious	0.22	0.45	0.3	neutral	0.77	disease	0.53	disease	0.71	disease	4	0.64	neutral	0.42	neutral	0	NA	0.53	deleterious	-0.83	medium_impact	0.06	medium_impact	1.04	medium_impact	0.87	0.9	24.34	21.11	0.42	N	0.65	NA	NA	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14309	14309	C	G	MI.23428	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	365	122	G	A	gGa/gCa	-6.94	0	0	benign	0.15	neutral	0.56	neutral	2.33	deleterious	-4.4	deleterious	-3.55	low_impact	1.55	0.82	neutral	0.66	neutral	2.21	17.59	deleterious	0.4	0.5	0.26	neutral	0.84	disease	0.44	neutral	0.59	disease	2	0.34	neutral	0.71	deleterious	-6	neutral	0.29	neutral	-0.11	medium_impact	0.27	medium_impact	0.16	medium_impact	0.84	0.9	47.35	8.39	0.33	N	0.79	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14309	14309	C	A	MI.23429	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	365	122	G	V	gGa/gTa	-6.94	0	0	possibly_damaging	0.85	neutral	0.52	neutral	2.27	deleterious	-5.73	deleterious	-5.78	medium_impact	2.25	0.8	neutral	0.67	neutral	4.21	23.90	deleterious	0.24	0.45	0.25	neutral	0.91	disease	0.44	neutral	0.59	disease	2	0.83	neutral	0.34	neutral	0	NA	0.76	deleterious	-1.49	low_impact	0.23	medium_impact	0.75	medium_impact	0.87	0.9	47.35	8.39	0.34	N	0.96	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6120	6120	A	C	MI.2343	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	217	73	I	L	Atc/Ctc	-12.6	0	0	probably_damaging	0.98	neutral	0.11	neutral	2.85	neutral	0.42	neutral	-1.09	medium_impact	2.2	0.63	neutral	0.51	neutral	3.65	23.20	deleterious	0.36	0.55	0.25	neutral	0.62	disease	0.43	neutral	0.47	neutral	1	0.99	deleterious	0.07	neutral	1	deleterious	0.64	deleterious	-2.35	low_impact	-0.31	medium_impact	0.93	medium_impact	0.73	0.9	5.65	37.31	0.5	N	0.25	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14309	14309	C	T	MI.23430	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	365	122	G	E	gGa/gAa	-6.94	0	0	possibly_damaging	0.89	neutral	0.36	neutral	2.41	deleterious	-5.32	deleterious	-3.36	low_impact	1.27	0.9	neutral	0.85	neutral	1.01	10.74	neutral	0.36	0.5	0.38	neutral	0.87	disease	0.51	disease	0.58	disease	2	0.89	neutral	0.24	neutral	-3	neutral	0.80	deleterious	-1.63	low_impact	0.07	medium_impact	-0.08	medium_impact	0.81	0.85	47.35	8.39	0.33	N	0.99	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14310	14310	C	G	MI.23431	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	364	122	G	R	Gga/Cga	-0.29	0	0	probably_damaging	0.96	neutral	0.37	neutral	2.28	deleterious	-5.95	deleterious	-4.79	medium_impact	3.22	0.75	neutral	0.23	damaging	4.14	23.80	deleterious	0.27	0.45	0.43	neutral	0.91	disease	0.6	disease	0.76	disease	5	0.96	neutral	0.21	neutral	1	deleterious	0.83	deleterious	-2.06	low_impact	0.08	medium_impact	1.56	medium_impact	0.91	0.95	47.35	8.39	0.29	N	0.98	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14310	14310	C	A	MI.23432	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	364	122	G	W	Gga/Tga	-0.29	0	0	probably_damaging	0.99	neutral	0.19	neutral	2.24	deleterious	-8.54	deleterious	-5.68	medium_impact	3.22	0.77	neutral	0.26	damaging	4.79	24.70	deleterious	0.22	0.45	0.72	disease	0.93	disease	0.56	disease	0.76	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.86	deleterious	-2.63	low_impact	-0.14	medium_impact	1.56	medium_impact	0.69	0.85	47.35	8.39	0.29	N	0.99	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14312	14312	A	C	MI.23433	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	362	121	V	G	gTa/gGa	-8.31	0	0	benign	0.3	neutral	0.42	neutral	2.2	deleterious	-5.02	deleterious	-4	low_impact	0.94	0.79	neutral	0.76	neutral	1.79	14.90	neutral	0.24	0.45	0.43	neutral	0.61	disease	0.46	neutral	0.48	neutral	0	0.49	neutral	0.56	deleterious	-6	neutral	0.33	neutral	-0.46	medium_impact	0.13	medium_impact	-0.35	medium_impact	0.65	0.8	23.01	21.88	0.31	N	0.81	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14312	14312	A	T	MI.23434	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	362	121	V	E	gTa/gAa	-8.31	0	0	possibly_damaging	0.5	neutral	0.46	neutral	2.21	deleterious	-5.19	deleterious	-3.42	low_impact	1.13	0.9	neutral	0.86	neutral	1.54	13.50	neutral	0.27	0.45	0.16	neutral	0.77	disease	0.42	neutral	0.61	disease	2	0.53	neutral	0.48	deleterious	-3	neutral	0.43	neutral	-0.8	medium_impact	0.17	medium_impact	-0.19	medium_impact	0.70	0.85	23.01	21.88	0.31	N	0.83	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14312	14312	A	G	MI.23435	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	362	121	V	A	gTa/gCa	-8.31	0	0	benign	0.01	neutral	0.64	neutral	2.24	deleterious	-3.61	neutral	-1.69	low_impact	0.94	0.91	neutral	0.98	neutral	0.60	8.14	deleterious	0.42	0.55	0.2	neutral	0.48	neutral	0.51	disease	0.44	neutral	1	0.34	neutral	0.82	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.35	medium_impact	-0.35	medium_impact	0.73	0.85	23.01	21.88	0.32	N	0.40	NA	NA	0.28	.	.	.	.	.	.	COSM1138261	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14313	14313	C	G	MI.23436	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	361	121	V	L	Gta/Cta	-0.29	0	0	benign	0.05	neutral	0.72	neutral	2.34	neutral	-2.68	neutral	0.59	neutral_impact	0.42	0.89	neutral	0.96	neutral	-0.82	0.04	neutral	0.44	0.55	0.11	neutral	0.27	neutral	0.36	neutral	0.42	neutral	2	0.2	neutral	0.84	deleterious	-6	neutral	0.11	neutral	0.38	medium_impact	0.43	medium_impact	-0.79	medium_impact	0.87	0.9	23.01	21.88	0.33	N	0.40	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14313	14313	C	A	MI.23437	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	361	121	V	L	Gta/Tta	-0.29	0	0	benign	0.05	neutral	0.72	neutral	2.34	neutral	-2.68	neutral	0.59	neutral_impact	0.42	0.89	neutral	0.96	neutral	-0.51	0.21	neutral	0.44	0.55	0.11	neutral	0.27	neutral	0.36	neutral	0.42	neutral	2	0.2	neutral	0.84	deleterious	-6	neutral	0.11	neutral	0.38	medium_impact	0.43	medium_impact	-0.79	medium_impact	0.87	0.9	23.01	21.88	0.4	N	0.40	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14313	14313	C	T	MI.23438	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	361	121	V	M	Gta/Ata	-0.29	0	0	benign	0.04	neutral	0.24	neutral	2.23	deleterious	-4.64	neutral	1.04	neutral_impact	-0.2	0.97	neutral	0.95	neutral	-0.54	0.18	neutral	0.48	0.55	0.29	neutral	0.22	neutral	0.38	neutral	0.4	neutral	2	0.74	neutral	0.6	deleterious	-6	neutral	0.12	neutral	0.47	medium_impact	-0.07	medium_impact	-1.31	low_impact	0.84	0.9	23.01	21.88	0.57	P	0.29	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14315	14315	C	G	MI.23439	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	359	120	S	T	aGt/aCt	-2.81	0	0	benign	0.01	neutral	0.41	neutral	2.24	deleterious	-3.46	neutral	-1.55	low_impact	0.9	0.94	neutral	0.95	neutral	0.80	9.47	deleterious	0.24	0.45	0.25	neutral	0.31	neutral	0.47	neutral	0.45	neutral	1	0.58	neutral	0.7	deleterious	-6	neutral	0.14	neutral	1.03	medium_impact	0.12	medium_impact	-0.39	medium_impact	0.68	0.85	50.44	8.68	0.46	N	0.28	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6120	6120	A	T	MI.2344	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	217	73	I	F	Atc/Ttc	-12.6	0	0	probably_damaging	1	neutral	0.06	neutral	2.88	neutral	0.6	neutral	-2.29	medium_impact	2.04	0.59	damaging	0.52	neutral	3.79	23.40	deleterious	0.38	0.55	0.4	neutral	0.75	disease	0.34	neutral	0.55	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.58	low_impact	-0.47	medium_impact	0.79	medium_impact	0.80	0.9	5.65	37.31	0.43	N	0.57	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14315	14315	C	T	MI.23440	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	359	120	S	N	aGt/aAt	-2.81	0	0	benign	0	neutral	0.35	neutral	2.29	deleterious	-4.18	neutral	0.27	neutral_impact	0.49	0.95	neutral	0.98	neutral	0.37	6.35	deleterious	0.54	0.6	0.27	neutral	0.39	neutral	0.37	neutral	0.44	neutral	1	0.65	neutral	0.68	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.06	medium_impact	-0.73	medium_impact	0.70	0.85	50.44	8.68	0.52	N	0.05	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14315	14315	C	A	MI.23441	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	359	120	S	I	aGt/aTt	-2.81	0	0	benign	0.4	neutral	0.41	neutral	2.34	deleterious	-4.77	deleterious	-3.88	low_impact	1.59	0.85	neutral	0.72	neutral	4.40	24.10	deleterious	0.33	0.5	0.45	neutral	0.7	disease	0.55	disease	0.68	disease	4	0.53	neutral	0.51	deleterious	-6	neutral	0.37	neutral	-0.64	medium_impact	0.12	medium_impact	0.19	medium_impact	0.85	0.9	50.44	8.68	0.35	N	0.74	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14316	14316	T	A	MI.23442	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	358	120	S	C	Agt/Tgt	-2.81	0	0	possibly_damaging	0.86	neutral	0.18	neutral	2.16	deleterious	-5.59	deleterious	-3.46	low_impact	1.94	0.86	neutral	0.74	neutral	3.81	23.40	deleterious	0.29	0.45	0.63	disease	0.67	disease	0.43	neutral	0.53	disease	1	0.92	neutral	0.16	neutral	-3	neutral	0.69	deleterious	-1.52	low_impact	-0.16	medium_impact	0.49	medium_impact	0.78	0.85	50.44	8.68	0.44	N	0.57	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14316	14316	T	G	MI.23443	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	358	120	S	R	Agt/Cgt	-2.81	0	0	benign	0.21	neutral	0.36	neutral	2.2	deleterious	-4.42	neutral	-2.16	medium_impact	2.29	0.77	neutral	0.56	neutral	3.77	23.40	deleterious	0.28	0.45	0.26	neutral	0.69	disease	0.58	disease	0.72	disease	4	0.57	neutral	0.58	deleterious	-3	neutral	0.30	neutral	-0.27	medium_impact	0.07	medium_impact	0.78	medium_impact	0.85	0.9	50.44	8.68	0.37	N	0.60	NA	NA	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14316	14316	T	C	MI.23444	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	358	120	S	G	Agt/Ggt	-2.81	0	0	benign	0.14	neutral	0.36	neutral	2.24	deleterious	-3.71	neutral	0.5	neutral_impact	0.16	0.88	neutral	1	neutral	-0.87	0.03	neutral	0.27	0.45	0.09	neutral	0.16	neutral	0.31	neutral	0.23	neutral	5	0.58	neutral	0.61	deleterious	-6	neutral	0.13	neutral	-0.07	medium_impact	0.07	medium_impact	-1.01	low_impact	0.68	0.85	50.44	8.68	0.43	N	0.09	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14317	14317	A	T	MI.23445	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	357	119	N	K	aaT/aaA	-4.87	0	0	benign	0.02	neutral	0.32	neutral	2.1	deleterious	-3.49	neutral	-2.28	neutral_impact	0.46	0.95	neutral	0.78	neutral	0.92	10.20	neutral	0.62	0.65	0.14	neutral	0.58	disease	0.46	neutral	0.44	neutral	1	0.67	neutral	0.65	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	0.03	medium_impact	-0.76	medium_impact	0.64	0.8	24.34	26.09	0.43	N	0.59	NA	NA	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14317	14317	A	C	MI.23446	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	357	119	N	K	aaT/aaG	-4.87	0	0	benign	0.02	neutral	0.32	neutral	2.1	deleterious	-3.49	neutral	-2.28	neutral_impact	0.46	0.95	neutral	0.78	neutral	0.57	7.94	deleterious	0.62	0.65	0.14	neutral	0.58	disease	0.46	neutral	0.44	neutral	1	0.67	neutral	0.65	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	0.03	medium_impact	-0.76	medium_impact	0.64	0.8	24.34	26.09	0.43	N	0.59	NA	NA	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14318	14318	T	C	MI.23447	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	356	119	N	S	aAt/aGt	-0.29	0	0.02	benign	0.02	neutral	0.44	neutral	2.17	deleterious	-3.41	neutral	-1.98	neutral_impact	0.66	0.93	neutral	0.96	neutral	-0.55	0.17	neutral	0.48	0.55	0.1	neutral	0.47	neutral	0.42	neutral	0.44	neutral	1	0.54	neutral	0.71	deleterious	-6	neutral	0.12	neutral	0.75	medium_impact	0.15	medium_impact	-0.59	medium_impact	0.36	0.8	24.34	26.09	0.41	N	0.10	NA	NA	0.31	rs28357675	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14318	14318	T	A	MI.23448	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	356	119	N	I	aAt/aTt	-0.29	0	0.02	possibly_damaging	0.76	neutral	0.41	neutral	2.06	deleterious	-4.99	deleterious	-5.2	low_impact	1.74	0.78	neutral	0.65	neutral	2.95	22.00	deleterious	0.26	0.45	0.28	neutral	0.75	disease	0.54	disease	0.69	disease	4	0.76	neutral	0.33	neutral	-3	neutral	0.57	deleterious	-1.26	low_impact	0.12	medium_impact	0.32	medium_impact	0.41	0.8	24.34	26.09	0.27	N	0.79	NA	NA	0.53	rs28357675	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14318	14318	T	G	MI.23449	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	356	119	N	T	aAt/aCt	-0.29	0	0.02	benign	0.2	neutral	0.41	neutral	2.1	deleterious	-3.9	deleterious	-3.15	medium_impact	1.99	0.82	neutral	0.73	neutral	0.87	9.90	deleterious	0.38	0.5	0.19	neutral	0.57	disease	0.53	disease	0.62	disease	2	0.51	neutral	0.61	deleterious	-3	neutral	0.28	neutral	-0.24	medium_impact	0.12	medium_impact	0.53	medium_impact	0.50	0.8	24.34	26.09	0.39	N	0.18	NA	NA	0.56	rs28357675	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6121	6121	T	G	MI.2345	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	218	73	I	S	aTc/aGc	3.13	0.99	0	probably_damaging	1	deleterious	0.04	neutral	2.72	neutral	-1.39	deleterious	-3.6	medium_impact	3.23	0.65	neutral	0.44	neutral	4.19	23.80	deleterious	0.27	0.55	0.36	neutral	0.79	disease	0.49	neutral	0.61	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-0.58	medium_impact	1.88	medium_impact	0.68	0.9	5.65	37.31	0.45	N	0.58	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14319	14319	T	A	MI.23450	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	355	119	N	Y	Aat/Tat	-2.12	0	0.01	possibly_damaging	0.86	neutral	1	neutral	2.03	deleterious	-5.29	deleterious	-3.86	low_impact	1.09	0.9	neutral	0.85	neutral	2.44	19.08	deleterious	0.32	0.5	0.37	neutral	0.7	disease	0.44	neutral	0.58	disease	2	0.86	neutral	0.57	deleterious	-3	neutral	0.65	deleterious	-1.52	low_impact	1.87	high_impact	-0.23	medium_impact	0.63	0.8	24.34	26.09	0.31	N	0.30	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14319	14319	T	C	MI.23451	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	355	119	N	D	Aat/Gat	-2.12	0	0.01	benign	0.01	neutral	0.23	neutral	2.06	deleterious	-3.24	neutral	-1.82	neutral_impact	0.4	0.94	neutral	0.97	neutral	0.07	3.27	deleterious	0.57	0.65	0.14	neutral	0.34	neutral	0.43	neutral	0.44	neutral	1	0.77	neutral	0.61	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	-0.09	medium_impact	-0.81	medium_impact	0.57	0.8	24.34	26.09	0.61	P	0.20	NA	NA	0.37	rs199476110	risk_factor	Parkinson_disease_6,_autosomal_recessive_early-onset	24734	MedGen:C1853833,OMIM:605909	.	.	CPD	0.15	T14319C	PD, early onset	+	-	Reported	2	N	P	N,P	neutral
chrM	14319	14319	T	G	MI.23452	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	355	119	N	H	Aat/Cat	-2.12	0	0.01	possibly_damaging	0.81	neutral	0.54	neutral	2.03	deleterious	-5.1	deleterious	-2.55	low_impact	1.74	0.85	neutral	0.7	neutral	2.00	16.23	deleterious	0.44	0.55	0.32	neutral	0.58	disease	0.49	neutral	0.5	disease	0	0.78	neutral	0.37	neutral	-3	neutral	0.60	deleterious	-1.37	low_impact	0.25	medium_impact	0.32	medium_impact	0.56	0.8	24.34	26.09	0.24	N	0.35	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14320	14320	A	C	MI.23453	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	354	118	F	L	ttT/ttG	-0.29	0	0	benign	0.02	neutral	0.72	neutral	2.44	neutral	-2.75	deleterious	-3.86	neutral_impact	0.56	0.93	neutral	0.82	neutral	0.70	8.84	deleterious	0.38	0.5	0.15	neutral	0.76	disease	0.59	disease	0.59	disease	2	0.25	neutral	0.85	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.43	medium_impact	-0.67	medium_impact	0.68	0.85	47.35	8.78	0.29	N	0.51	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14320	14320	A	T	MI.23454	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	354	118	F	L	ttT/ttA	-0.29	0	0	benign	0.02	neutral	0.72	neutral	2.44	neutral	-2.75	deleterious	-3.86	neutral_impact	0.56	0.93	neutral	0.82	neutral	0.83	9.68	deleterious	0.38	0.5	0.15	neutral	0.76	disease	0.59	disease	0.59	disease	2	0.25	neutral	0.85	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.43	medium_impact	-0.67	medium_impact	0.68	0.85	47.35	8.78	0.27	N	0.51	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14321	14321	A	G	MI.23455	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	353	118	F	S	tTt/tCt	-0.06	0	0	possibly_damaging	0.82	neutral	0.55	neutral	2.33	deleterious	-4.91	deleterious	-6.29	medium_impact	2.1	0.84	neutral	0.81	neutral	3.15	22.60	deleterious	0.34	0.5	0.4	neutral	0.9	disease	0.64	disease	0.6	disease	2	0.79	neutral	0.37	neutral	0	NA	0.68	deleterious	-1.4	low_impact	0.26	medium_impact	0.62	medium_impact	0.62	0.8	47.35	8.78	0.32	N	0.92	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14321	14321	A	T	MI.23456	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	353	118	F	Y	tTt/tAt	-0.06	0	0	benign	0.03	neutral	1	neutral	2.31	deleterious	-3.12	neutral	-1.97	low_impact	0.96	0.93	neutral	0.87	neutral	0.70	8.83	deleterious	0.33	0.5	0.43	neutral	0.81	disease	0.61	disease	0.6	disease	2	0.03	neutral	0.99	deleterious	-6	neutral	0.26	neutral	0.59	medium_impact	1.87	high_impact	-0.34	medium_impact	0.56	0.8	47.35	8.78	0.33	N	0.77	NA	NA	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14321	14321	A	C	MI.23457	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	353	118	F	C	tTt/tGt	-0.06	0	0	probably_damaging	0.96	neutral	0.18	neutral	2.26	deleterious	-6.52	deleterious	-5.55	medium_impact	2.2	0.87	neutral	0.79	neutral	3.70	23.30	deleterious	0.26	0.45	0.61	disease	0.93	disease	0.64	disease	0.62	disease	2	0.97	neutral	0.11	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	-0.16	medium_impact	0.7	medium_impact	0.50	0.8	47.35	8.78	0.38	N	0.55	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14322	14322	A	C	MI.23458	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	352	118	F	V	Ttt/Gtt	0.63	0.07	0	benign	0.37	neutral	0.59	neutral	2.34	deleterious	-3.78	deleterious	-4.97	low_impact	1.58	0.84	neutral	0.83	neutral	2.09	16.78	deleterious	0.3	0.45	0.14	neutral	0.87	disease	0.61	disease	0.59	disease	2	0.35	neutral	0.61	deleterious	-6	neutral	0.36	neutral	-0.58	medium_impact	0.29	medium_impact	0.18	medium_impact	0.70	0.85	47.35	8.78	0.28	N	0.83	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14322	14322	A	T	MI.23459	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	352	118	F	I	Ttt/Att	0.63	0.07	0	benign	0.26	neutral	0.43	neutral	2.32	deleterious	-3.78	deleterious	-4.13	low_impact	1.85	0.85	neutral	0.83	neutral	2.37	18.60	deleterious	0.31	0.45	0.2	neutral	0.86	disease	0.62	disease	0.59	disease	2	0.48	neutral	0.59	deleterious	-6	neutral	0.43	neutral	-0.38	medium_impact	0.14	medium_impact	0.41	medium_impact	0.61	0.8	47.35	8.78	0.4	N	0.82	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6121	6121	T	A	MI.2346	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	218	73	I	N	aTc/aAc	3.13	0.99	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.05	deleterious	-4.26	high_impact	3.78	0.64	neutral	0.4	neutral	4.32	24.00	deleterious	0.27	0.55	0.6	disease	0.79	disease	0.49	neutral	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.39	high_impact	0.65	0.9	5.65	37.31	0.48	N	0.77	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14322	14322	A	G	MI.23460	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	352	118	F	L	Ttt/Ctt	0.63	0.07	0	benign	0.02	neutral	0.72	neutral	2.44	neutral	-2.75	deleterious	-3.86	neutral_impact	0.56	0.93	neutral	0.82	neutral	0.72	8.97	deleterious	0.38	0.5	0.15	neutral	0.76	disease	0.59	disease	0.59	disease	2	0.25	neutral	0.85	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.43	medium_impact	-0.67	medium_impact	0.68	0.85	47.35	8.78	0.32	N	0.51	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14323	14323	G	T	MI.23461	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	351	117	N	K	aaC/aaA	2.92	0.08	0	possibly_damaging	0.49	neutral	0.59	neutral	2.32	deleterious	-3.49	neutral	-0.6	low_impact	1.17	0.89	neutral	0.92	neutral	1.30	12.26	neutral	0.62	0.65	0.11	neutral	0.56	disease	0.47	neutral	0.42	neutral	2	0.44	neutral	0.55	deleterious	-3	neutral	0.40	neutral	-0.78	medium_impact	0.29	medium_impact	-0.16	medium_impact	0.77	0.85	22.57	16.62	0.38	N	0.21	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14323	14323	G	C	MI.23462	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	351	117	N	K	aaC/aaG	2.92	0.08	0	possibly_damaging	0.49	neutral	0.59	neutral	2.32	deleterious	-3.49	neutral	-0.6	low_impact	1.17	0.89	neutral	0.92	neutral	1.14	11.43	neutral	0.62	0.65	0.11	neutral	0.56	disease	0.47	neutral	0.42	neutral	2	0.44	neutral	0.55	deleterious	-3	neutral	0.40	neutral	-0.78	medium_impact	0.29	medium_impact	-0.16	medium_impact	0.77	0.85	22.57	16.62	0.33	N	0.21	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14324	14324	T	C	MI.23463	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	350	117	N	S	aAc/aGc	-2.81	0	0	benign	0.05	neutral	0.66	neutral	2.35	deleterious	-3.41	neutral	-0.69	neutral_impact	0.42	0.92	neutral	0.94	neutral	-0.89	0.03	neutral	0.61	0.65	0.19	neutral	0.42	neutral	0.44	neutral	0.45	neutral	1	0.27	neutral	0.81	deleterious	-6	neutral	0.14	neutral	0.38	medium_impact	0.37	medium_impact	-0.79	medium_impact	0.50	0.8	22.57	16.62	0.34	N	0.05	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14324	14324	T	G	MI.23464	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	350	117	N	T	aAc/aCc	-2.81	0	0	possibly_damaging	0.49	neutral	0.58	neutral	2.41	deleterious	-3.9	neutral	-1.78	medium_impact	1.98	0.83	neutral	0.79	neutral	0.58	8.03	deleterious	0.4	0.5	0.24	neutral	0.47	neutral	0.54	disease	0.46	neutral	1	0.44	neutral	0.55	deleterious	0	NA	0.40	neutral	-0.78	medium_impact	0.28	medium_impact	0.52	medium_impact	0.56	0.8	22.57	16.62	0.36	N	0.30	NA	NA	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14324	14324	T	A	MI.23465	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	350	117	N	I	aAc/aTc	-2.81	0	0	possibly_damaging	0.88	neutral	0.48	neutral	2.31	deleterious	-4.99	deleterious	-3.54	medium_impact	1.98	0.81	neutral	0.62	neutral	3.30	22.90	deleterious	0.3	0.45	0.47	neutral	0.72	disease	0.57	disease	0.73	disease	5	0.87	neutral	0.3	neutral	0	NA	0.69	deleterious	-1.59	low_impact	0.19	medium_impact	0.52	medium_impact	0.44	0.8	22.57	16.62	0.27	N	0.77	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14325	14325	T	G	MI.23466	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	349	117	N	H	Aac/Cac	-0.06	0	0.02	probably_damaging	0.91	neutral	0.56	neutral	2.23	deleterious	-5.1	neutral	-1.41	medium_impact	2.17	0.8	neutral	0.64	neutral	2.26	17.87	deleterious	0.46	0.55	0.36	neutral	0.55	disease	0.62	disease	0.71	disease	4	0.9	neutral	0.33	neutral	1	deleterious	0.64	deleterious	-1.72	low_impact	0.27	medium_impact	0.68	medium_impact	0.54	0.8	22.57	16.62	0.27	N	0.41	NA	NA	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14325	14325	T	A	MI.23467	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	349	117	N	Y	Aac/Tac	-0.06	0	0.02	probably_damaging	0.94	neutral	1	neutral	2.23	deleterious	-5.29	deleterious	-2.72	low_impact	1.83	0.88	neutral	0.83	neutral	2.89	21.80	deleterious	0.32	0.5	0.5	disease	0.69	disease	0.55	disease	0.57	disease	1	0.94	neutral	0.53	deleterious	-2	neutral	0.72	deleterious	-1.89	low_impact	1.87	high_impact	0.39	medium_impact	0.63	0.8	22.57	16.62	0.28	N	0.76	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14325	14325	T	C	MI.23468	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	349	117	N	D	Aac/Gac	-0.06	0	0.02	possibly_damaging	0.49	neutral	0.42	neutral	2.27	deleterious	-3.24	neutral	0.7	low_impact	0.96	0.91	neutral	0.98	neutral	-0.04	2.18	deleterious	0.59	0.65	0.08	neutral	0.34	neutral	0.44	neutral	0.43	neutral	1	0.56	neutral	0.47	neutral	-3	neutral	0.40	neutral	-0.78	medium_impact	0.13	medium_impact	-0.34	medium_impact	0.65	0.8	22.57	16.62	0.54	P	0.11	NA	NA	0.19	rs397515505	Pathogenic	Leber's_optic_atrophy	76420	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	COSM1155554	CPD	0.89	T14325C	LHON	+	-	Reported	1	P	P	P	neutral
chrM	14327	14327	A	C	MI.23469	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	347	116	V	G	gTa/gGa	-3.96	0	0	possibly_damaging	0.79	neutral	0.43	neutral	2.29	deleterious	-5.02	deleterious	-3.25	medium_impact	2.01	0.84	neutral	0.78	neutral	2.24	17.75	deleterious	0.19	0.45	0.47	neutral	0.62	disease	0.6	disease	0.49	neutral	0	0.79	neutral	0.32	neutral	0	NA	0.63	deleterious	-1.32	low_impact	0.14	medium_impact	0.54	medium_impact	0.74	0.85	49.56	8.7	0.38	N	0.87	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6121	6121	T	C	MI.2347	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	218	73	I	T	aTc/aCc	3.13	0.99	0	probably_damaging	1	neutral	0.14	neutral	2.73	neutral	-1.12	deleterious	-2.95	medium_impact	2.34	0.61	neutral	0.47	neutral	3.31	22.90	deleterious	0.44	0.55	0.19	neutral	0.66	disease	0.37	neutral	0.46	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.71	deleterious	-3.58	low_impact	-0.25	medium_impact	1.06	medium_impact	0.70	0.9	5.65	37.31	0.48	N	0.70	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14327	14327	A	G	MI.23470	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	347	116	V	A	gTa/gCa	-3.96	0	0	benign	0.34	neutral	0.64	neutral	2.37	deleterious	-3.61	neutral	-1.77	medium_impact	2.21	0.87	neutral	0.85	neutral	0.65	8.47	deleterious	0.34	0.5	0.24	neutral	0.53	disease	0.56	disease	0.45	neutral	1	0.29	neutral	0.65	deleterious	-3	neutral	0.29	neutral	-0.53	medium_impact	0.35	medium_impact	0.71	medium_impact	0.75	0.85	49.56	8.7	0.33	N	0.62	NA	NA	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14327	14327	A	T	MI.23471	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	347	116	V	E	gTa/gAa	-3.96	0	0	possibly_damaging	0.86	neutral	0.49	neutral	2.31	deleterious	-5.19	deleterious	-3.11	low_impact	1.41	0.88	neutral	0.87	neutral	3.04	22.40	deleterious	0.13	0.4	0.48	neutral	0.78	disease	0.72	disease	0.64	disease	3	0.85	neutral	0.32	neutral	-3	neutral	0.69	deleterious	-1.52	low_impact	0.2	medium_impact	0.04	medium_impact	0.78	0.85	49.56	8.7	0.33	N	0.88	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14328	14328	C	A	MI.23472	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	346	116	V	L	Gta/Tta	0.17	0	0	benign	0.02	neutral	0.77	neutral	2.42	neutral	-2.68	neutral	-0.35	neutral_impact	0.72	0.94	neutral	0.97	neutral	-0.01	2.51	deleterious	0.37	0.5	0.13	neutral	0.39	neutral	0.39	neutral	0.44	neutral	1	0.18	neutral	0.88	deleterious	-6	neutral	0.11	neutral	0.75	medium_impact	0.5	medium_impact	-0.54	medium_impact	0.84	0.9	49.56	8.7	0.39	N	0.31	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14328	14328	C	G	MI.23473	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	346	116	V	L	Gta/Cta	0.17	0	0	benign	0.02	neutral	0.77	neutral	2.42	neutral	-2.68	neutral	-0.35	neutral_impact	0.72	0.94	neutral	0.97	neutral	-0.29	0.69	neutral	0.37	0.5	0.13	neutral	0.39	neutral	0.39	neutral	0.44	neutral	1	0.18	neutral	0.88	deleterious	-6	neutral	0.11	neutral	0.75	medium_impact	0.5	medium_impact	-0.54	medium_impact	0.84	0.9	49.56	8.7	0.39	N	0.31	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14328	14328	C	T	MI.23474	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	346	116	V	M	Gta/Ata	0.17	0	0	benign	0.23	neutral	0.32	neutral	2.3	deleterious	-4.64	neutral	-0.48	low_impact	1.06	0.88	neutral	0.74	neutral	2.62	20.30	deleterious	0.35	0.5	0.3	neutral	0.36	neutral	0.48	neutral	0.46	neutral	1	0.61	neutral	0.55	deleterious	-6	neutral	0.17	neutral	-0.32	medium_impact	0.03	medium_impact	-0.25	medium_impact	0.83	0.85	49.56	8.7	0.48	N	0.55	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14330	14330	A	G	MI.23475	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	344	115	V	A	gTg/gCg	-12.9	0	0	benign	0	neutral	0.55	neutral	2.35	deleterious	-3.58	neutral	-2.03	low_impact	1.18	0.93	neutral	0.94	neutral	0.65	8.49	deleterious	0.31	0.5	0.18	neutral	0.52	disease	0.57	disease	0.46	neutral	1	0.44	neutral	0.78	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.26	medium_impact	-0.15	medium_impact	0.67	0.85	21.24	12.41	0.39	N	0.71	NA	NA	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14330	14330	A	T	MI.23476	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	344	115	V	E	gTg/gAg	-12.9	0	0	benign	0.01	neutral	0.42	neutral	2.35	deleterious	-5.22	deleterious	-3.79	medium_impact	2.42	0.87	neutral	0.78	neutral	1.39	12.73	neutral	0.16	0.45	0.34	neutral	0.8	disease	0.65	disease	0.63	disease	3	0.57	neutral	0.71	deleterious	-3	neutral	0.22	neutral	1.03	medium_impact	0.13	medium_impact	0.89	medium_impact	0.77	0.85	21.24	12.41	0.37	N	0.94	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14330	14330	A	C	MI.23477	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	344	115	V	G	gTg/gGg	-12.9	0	0	benign	0.09	neutral	0.38	neutral	2.34	deleterious	-5.42	deleterious	-3.73	low_impact	1.62	0.89	neutral	0.96	neutral	0.48	7.29	deleterious	0.21	0.45	0.37	neutral	0.6	disease	0.51	disease	0.47	neutral	1	0.57	neutral	0.65	deleterious	-6	neutral	0.20	neutral	0.13	medium_impact	0.09	medium_impact	0.22	medium_impact	0.69	0.85	21.24	12.41	0.42	N	0.93	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14331	14331	C	A	MI.23478	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	343	115	V	L	Gtg/Ttg	0.17	0	0	benign	0.03	neutral	0.71	neutral	2.36	neutral	-0.99	neutral	-1.37	low_impact	1.53	0.88	neutral	0.93	neutral	0.79	9.40	deleterious	0.38	0.5	0.14	neutral	0.38	neutral	0.43	neutral	0.44	neutral	1	0.24	neutral	0.84	deleterious	-6	neutral	0.11	neutral	0.59	medium_impact	0.42	medium_impact	0.14	medium_impact	0.84	0.9	21.24	12.41	0.36	N	0.40	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14331	14331	C	T	MI.23479	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	343	115	V	M	Gtg/Atg	0.17	0	0	benign	0.02	neutral	0.27	neutral	2.3	deleterious	-3.82	neutral	-1.45	medium_impact	2.08	0.91	neutral	0.94	neutral	0.83	9.63	deleterious	0.39	0.5	0.27	neutral	0.33	neutral	0.46	neutral	0.46	neutral	1	0.72	neutral	0.63	deleterious	-3	neutral	0.12	neutral	0.75	medium_impact	-0.03	medium_impact	0.6	medium_impact	0.84	0.9	21.24	12.41	0.51	N	0.65	NA	NA	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6122	6122	C	G	MI.2348	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	219	73	I	M	atC/atG	7.53	1	0	probably_damaging	1	neutral	0.1	neutral	2.79	neutral	-0.21	neutral	-1.5	medium_impact	1.96	0.71	neutral	0.84	neutral	2.13	17.03	deleterious	0.49	0.55	0.41	neutral	0.5	neutral	0.3	neutral	0.47	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.70	deleterious	-3.58	low_impact	-0.34	medium_impact	0.71	medium_impact	0.84	0.9	5.65	37.31	0.55	P	0.02	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14331	14331	C	G	MI.23480	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	343	115	V	L	Gtg/Ctg	0.17	0	0	benign	0.03	neutral	0.71	neutral	2.36	neutral	-0.99	neutral	-1.37	low_impact	1.53	0.88	neutral	0.93	neutral	0.42	6.78	deleterious	0.38	0.5	0.14	neutral	0.38	neutral	0.43	neutral	0.44	neutral	1	0.24	neutral	0.84	deleterious	-6	neutral	0.11	neutral	0.59	medium_impact	0.42	medium_impact	0.14	medium_impact	0.84	0.9	21.24	12.41	0.35	N	0.40	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14333	14333	A	G	MI.23481	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	341	114	V	A	gTt/gCt	-3.04	0	0	possibly_damaging	0.45	neutral	0.55	neutral	2.23	neutral	-0.03	neutral	-2.21	medium_impact	2.05	0.89	neutral	0.91	neutral	1.22	11.87	neutral	0.3	0.45	0.51	disease	0.42	neutral	0.56	disease	0.43	neutral	1	0.43	neutral	0.55	deleterious	0	NA	0.41	neutral	-0.72	medium_impact	0.26	medium_impact	0.58	medium_impact	0.74	0.85	18.14	12.08	0.4	N	0.70	NA	NA	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14333	14333	A	C	MI.23482	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	341	114	V	G	gTt/gGt	-3.04	0	0	possibly_damaging	0.88	neutral	0.36	neutral	2.35	neutral	-0.34	deleterious	-3.68	medium_impact	2.51	0.89	neutral	0.87	neutral	2.64	20.50	deleterious	0.2	0.45	0.79	disease	0.5	neutral	0.6	disease	0.57	disease	1	0.88	neutral	0.24	neutral	0	NA	0.71	deleterious	-1.59	low_impact	0.07	medium_impact	0.96	medium_impact	0.76	0.85	18.14	12.08	0.44	N	0.91	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14333	14333	A	T	MI.23483	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	341	114	V	D	gTt/gAt	-3.04	0	0	probably_damaging	0.93	neutral	0.24	neutral	2.23	neutral	-0.67	deleterious	-3.81	medium_impact	2.86	0.89	neutral	0.85	neutral	3.46	23.00	deleterious	0.14	0.4	0.85	disease	0.71	disease	0.69	disease	0.71	disease	4	0.95	neutral	0.16	neutral	1	deleterious	0.76	deleterious	-1.83	low_impact	-0.07	medium_impact	1.26	medium_impact	0.79	0.85	18.14	12.08	0.45	N	0.94	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14334	14334	C	G	MI.23484	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	340	114	V	L	Gtt/Ctt	1.31	0	0	benign	0.21	neutral	0.68	neutral	2.38	neutral	-0.33	neutral	-0.58	low_impact	1.34	0.88	neutral	0.89	neutral	-0.07	1.95	neutral	0.39	0.5	0.22	neutral	0.28	neutral	0.38	neutral	0.43	neutral	1	0.21	neutral	0.74	deleterious	-6	neutral	0.19	neutral	-0.27	medium_impact	0.39	medium_impact	-0.02	medium_impact	0.87	0.9	18.14	12.08	0.35	N	0.67	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14334	14334	C	A	MI.23485	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	340	114	V	F	Gtt/Ttt	1.31	0	0	possibly_damaging	0.84	neutral	0.71	neutral	2.28	neutral	-2.45	neutral	-1.97	low_impact	1.7	0.89	neutral	0.89	neutral	2.63	20.40	deleterious	0.22	0.45	0.57	disease	0.63	disease	0.44	neutral	0.52	disease	0	0.81	neutral	0.44	neutral	-3	neutral	0.66	deleterious	-1.46	low_impact	0.42	medium_impact	0.28	medium_impact	0.78	0.85	18.14	12.08	0.32	N	0.86	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14334	14334	C	T	MI.23486	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	340	114	V	I	Gtt/Att	1.31	0	0	benign	0.1	neutral	0.41	neutral	2.32	neutral	-0.57	neutral	-0.05	low_impact	0.96	0.92	neutral	0.95	neutral	0.54	7.72	deleterious	0.42	0.55	0.2	neutral	0.18	neutral	0.4	neutral	0.35	neutral	3	0.53	neutral	0.66	deleterious	-6	neutral	0.12	neutral	0.08	medium_impact	0.12	medium_impact	-0.34	medium_impact	0.86	0.9	18.14	12.08	0.48	N	0.22	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14336	14336	A	C	MI.23487	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	338	113	V	G	gTg/gGg	-5.56	0	0	possibly_damaging	0.82	neutral	0.36	neutral	2.32	deleterious	-5.53	neutral	1.39	neutral_impact	0.61	0.92	neutral	0.91	neutral	2.16	17.25	deleterious	0.2	0.45	0.2	neutral	0.52	disease	0.42	neutral	0.44	neutral	1	0.83	neutral	0.27	neutral	-3	neutral	0.55	deleterious	-1.4	low_impact	0.07	medium_impact	-0.63	medium_impact	0.74	0.85	42.04	7.9	0.38	N	0.45	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14336	14336	A	T	MI.23488	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	338	113	V	E	gTg/gAg	-5.56	0	0	benign	0.02	neutral	0.34	neutral	2.34	deleterious	-5.46	neutral	4.05	neutral_impact	-0.2	0.95	neutral	0.93	neutral	0.22	4.87	deleterious	0.21	0.45	0.1	neutral	0.64	disease	0.44	neutral	0.44	neutral	1	0.65	neutral	0.66	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	0.05	medium_impact	-1.31	low_impact	0.75	0.85	42.04	7.9	0.35	N	0.12	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14336	14336	A	G	MI.23489	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	338	113	V	A	gTg/gCg	-5.56	0	0	possibly_damaging	0.46	neutral	0.56	neutral	2.33	deleterious	-3.78	neutral	1	medium_impact	2.08	0.88	neutral	0.88	neutral	2.00	16.23	deleterious	0.36	0.5	0.16	neutral	0.49	neutral	0.48	neutral	0.44	neutral	1	0.43	neutral	0.55	deleterious	0	NA	0.44	deleterious	-0.73	medium_impact	0.27	medium_impact	0.6	medium_impact	0.76	0.85	42.04	7.9	0.27	N	0.44	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6122	6122	C	A	MI.2349	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	219	73	I	M	atC/atA	7.53	1	0	probably_damaging	1	neutral	0.1	neutral	2.79	neutral	-0.21	neutral	-1.5	medium_impact	1.96	0.71	neutral	0.84	neutral	2.65	20.50	deleterious	0.49	0.55	0.41	neutral	0.5	neutral	0.3	neutral	0.47	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.70	deleterious	-3.58	low_impact	-0.34	medium_impact	0.71	medium_impact	0.84	0.9	5.65	37.31	0.55	P	0.02	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14337	14337	C	G	MI.23490	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	337	113	V	L	Gtg/Ctg	-0.75	0	0	possibly_damaging	0.62	neutral	0.67	neutral	2.45	neutral	-2.17	neutral	-0.52	low_impact	1.1	0.92	neutral	0.89	neutral	0.49	7.39	deleterious	0.42	0.55	0.11	neutral	0.34	neutral	0.47	neutral	0.44	neutral	1	0.55	neutral	0.53	deleterious	-3	neutral	0.46	deleterious	-0.99	medium_impact	0.38	medium_impact	-0.22	medium_impact	0.85	0.9	42.04	7.9	0.35	N	0.62	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14337	14337	C	A	MI.23491	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	337	113	V	L	Gtg/Ttg	-0.75	0	0	possibly_damaging	0.62	neutral	0.67	neutral	2.45	neutral	-2.17	neutral	-0.52	low_impact	1.1	0.92	neutral	0.89	neutral	0.83	9.64	deleterious	0.42	0.55	0.11	neutral	0.34	neutral	0.47	neutral	0.44	neutral	1	0.55	neutral	0.53	deleterious	-3	neutral	0.46	deleterious	-0.99	medium_impact	0.38	medium_impact	-0.22	medium_impact	0.85	0.9	42.04	7.9	0.33	N	0.62	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14337	14337	C	T	MI.23492	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	337	113	V	M	Gtg/Atg	-0.75	0	0	probably_damaging	0.95	neutral	0.23	neutral	2.26	deleterious	-4.16	neutral	0.06	medium_impact	2.08	0.89	neutral	0.86	neutral	1.16	11.54	neutral	0.44	0.55	0.28	neutral	0.28	neutral	0.52	disease	0.46	neutral	1	0.97	neutral	0.14	neutral	1	deleterious	0.64	deleterious	-1.97	low_impact	-0.09	medium_impact	0.6	medium_impact	0.84	0.9	42.04	7.9	0.51	N	0.58	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14339	14339	A	G	MI.23493	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	335	112	V	A	gTg/gCg	-6.48	0	0	benign	0.03	neutral	0.56	neutral	2.35	neutral	-2.67	neutral	-2.12	low_impact	1.46	0.89	neutral	0.9	neutral	1.12	11.33	neutral	0.35	0.5	0.27	neutral	0.5	disease	0.63	disease	0.49	neutral	0	0.4	neutral	0.77	deleterious	-6	neutral	0.15	neutral	0.59	medium_impact	0.27	medium_impact	0.08	medium_impact	0.75	0.85	5.75	12.69	0.29	N	0.60	NA	NA	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14339	14339	A	C	MI.23494	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	335	112	V	G	gTg/gGg	-6.48	0	0	benign	0.37	neutral	0.37	neutral	2.33	deleterious	-4.41	deleterious	-3.81	low_impact	1.52	0.93	neutral	0.88	neutral	1.05	10.92	neutral	0.21	0.45	0.32	neutral	0.57	disease	0.65	disease	0.5	neutral	0	0.56	neutral	0.5	deleterious	-6	neutral	0.35	neutral	-0.58	medium_impact	0.08	medium_impact	0.13	medium_impact	0.75	0.85	5.75	12.69	0.41	N	0.85	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14339	14339	A	T	MI.23495	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	335	112	V	E	gTg/gAg	-6.48	0	0	possibly_damaging	0.5	neutral	0.36	neutral	2.35	deleterious	-4.46	deleterious	-2.6	low_impact	1.69	0.9	neutral	0.87	neutral	1.98	16.07	deleterious	0.23	0.45	0.24	neutral	0.77	disease	0.78	disease	0.66	disease	3	0.62	neutral	0.43	neutral	-3	neutral	0.47	deleterious	-0.8	medium_impact	0.07	medium_impact	0.28	medium_impact	0.70	0.85	5.75	12.69	0.41	N	0.90	NA	NA	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14340	14340	C	A	MI.23496	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	334	112	V	L	Gtg/Ttg	1.08	0	0	benign	0.01	neutral	0.67	neutral	2.34	neutral	-1.7	neutral	-0.44	neutral_impact	0.53	0.96	neutral	0.89	neutral	0.26	5.31	deleterious	0.45	0.55	0.19	neutral	0.35	neutral	0.44	neutral	0.44	neutral	1	0.31	neutral	0.83	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.38	medium_impact	-0.7	medium_impact	0.87	0.9	5.75	12.69	0.36	N	0.55	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14340	14340	C	G	MI.23497	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	334	112	V	L	Gtg/Ctg	1.08	0	0	benign	0.01	neutral	0.67	neutral	2.34	neutral	-1.7	neutral	-0.44	neutral_impact	0.53	0.96	neutral	0.89	neutral	-0.02	2.42	deleterious	0.45	0.55	0.19	neutral	0.35	neutral	0.44	neutral	0.44	neutral	1	0.31	neutral	0.83	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.38	medium_impact	-0.7	medium_impact	0.87	0.9	5.75	12.69	0.36	N	0.55	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14340	14340	C	T	MI.23498	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	334	112	V	M	Gtg/Atg	1.08	0	0	possibly_damaging	0.69	neutral	0.23	neutral	2.28	deleterious	-3.4	neutral	-0.9	low_impact	1.6	0.92	neutral	0.91	neutral	1.25	12.03	neutral	0.4	0.5	0.36	neutral	0.28	neutral	0.48	neutral	0.45	neutral	1	0.81	neutral	0.27	neutral	-3	neutral	0.48	deleterious	-1.11	low_impact	-0.09	medium_impact	0.2	medium_impact	0.86	0.9	5.75	12.69	0.66	P	0.02	NA	NA	0.28	.	.	.	.	.	.	.	CPD	0.74	C14340T	SNHL	+	-	Reported	1	.	P	P	neutral
chrM	14342	14342	C	T	MI.23499	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	332	111	G	E	gGg/gAg	-3.73	0	0	benign	0.01	neutral	0.29	neutral	2.28	neutral	0.52	neutral	0.09	neutral_impact	-0.72	0.95	neutral	0.91	neutral	-0.42	0.35	neutral	0.38	0.5	0.11	neutral	0.71	disease	0.5	neutral	0.56	disease	1	0.7	neutral	0.64	deleterious	-6	neutral	0.15	neutral	1.03	medium_impact	-0.01	medium_impact	-1.74	low_impact	0.75	0.85	14.6	14.23	0.39	N	0.19	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8636	8636	T	A	MI.235	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	110	37	L	H	cTc/cAc	0.59	0.38	0	probably_damaging	0.96	neutral	0.08	neutral	4.28	deleterious	-3.65	deleterious	-3.7	medium_impact	2.86	0.8	neutral	0.4	neutral	3.83	23.40	deleterious	0.28	0.65	0.59	disease	0.7	disease	0.74	disease	0.77	disease	5	0.99	deleterious	0.06	neutral	1	deleterious	0.78	deleterious	-2.07	low_impact	-0.31	medium_impact	1.35	medium_impact	0.62	0.9	20.35	20.89	0.26	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6123	6123	A	G	MI.2350	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	220	74	M	V	Ata/Gta	-2.42	0	0	probably_damaging	0.94	neutral	0.05	neutral	2.79	neutral	0.7	neutral	-2.16	medium_impact	2.77	0.62	neutral	0.2	damaging	2.68	20.70	deleterious	0.43	0.55	0.28	neutral	0.92	disease	0.6	disease	0.57	disease	1	0.99	deleterious	0.06	neutral	1	deleterious	0.75	deleterious	-1.88	low_impact	-0.52	medium_impact	1.46	medium_impact	0.62	0.9	5.65	8.41	0.31	N	0.88	polymorphism	0.66	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14342	14342	C	A	MI.23500	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	332	111	G	V	gGg/gTg	-3.73	0	0	benign	0.41	neutral	0.51	neutral	2.35	neutral	0.71	deleterious	-2.71	neutral_impact	0.57	0.89	neutral	0.89	neutral	2.72	20.90	deleterious	0.33	0.5	0.51	disease	0.73	disease	0.51	disease	0.59	disease	2	0.44	neutral	0.55	deleterious	-6	neutral	0.40	neutral	-0.65	medium_impact	0.22	medium_impact	-0.66	medium_impact	0.80	0.85	14.6	14.23	0.25	N	0.59	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14342	14342	C	G	MI.23501	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	332	111	G	A	gGg/gCg	-3.73	0	0	benign	0.3	neutral	0.51	neutral	2.3	neutral	1.4	neutral	-1.35	low_impact	1.47	0.84	neutral	0.88	neutral	1.09	11.15	neutral	0.37	0.5	0.31	neutral	0.64	disease	0.53	disease	0.49	neutral	0	0.39	neutral	0.61	deleterious	-6	neutral	0.28	neutral	-0.46	medium_impact	0.22	medium_impact	0.09	medium_impact	0.77	0.85	14.6	14.23	0.3	N	0.12	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14343	14343	C	A	MI.23502	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	331	111	G	W	Ggg/Tgg	-0.52	0	0	probably_damaging	0.97	neutral	0.19	neutral	2.25	neutral	-0.67	deleterious	-2.96	low_impact	1.47	0.82	neutral	0.84	neutral	4.86	24.90	deleterious	0.24	0.45	0.87	disease	0.83	disease	0.7	disease	0.77	disease	5	0.98	deleterious	0.11	neutral	-2	neutral	0.79	deleterious	-2.18	low_impact	-0.14	medium_impact	0.09	medium_impact	0.61	0.8	14.6	14.23	0.27	N	0.60	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14343	14343	C	G	MI.23503	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	331	111	G	R	Ggg/Cgg	-0.52	0	0	possibly_damaging	0.54	neutral	0.35	neutral	2.25	neutral	-0.96	neutral	-1.18	low_impact	1.47	0.79	neutral	0.75	neutral	2.41	18.90	deleterious	0.31	0.45	0.38	neutral	0.81	disease	0.66	disease	0.75	disease	5	0.65	neutral	0.41	neutral	-3	neutral	0.47	deleterious	-0.86	medium_impact	0.06	medium_impact	0.09	medium_impact	0.92	0.95	14.6	14.23	0.26	N	0.50	NA	NA	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14344	14344	A	C	MI.23504	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	330	110	D	E	gaT/gaG	-0.29	0	0	benign	0.3	neutral	0.27	neutral	2.28	neutral	-1.18	neutral	-0.75	neutral_impact	-0.34	0.94	neutral	0.96	neutral	-0.59	0.13	neutral	0.43	0.55	0.12	neutral	0.32	neutral	0.31	neutral	0.45	neutral	1	0.67	neutral	0.49	deleterious	-6	neutral	0.28	neutral	-0.46	medium_impact	-0.03	medium_impact	-1.43	low_impact	0.64	0.8	22.12	15.91	0.44	N	0.13	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14344	14344	A	T	MI.23505	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	330	110	D	E	gaT/gaA	-0.29	0	0	benign	0.3	neutral	0.27	neutral	2.28	neutral	-1.18	neutral	-0.75	neutral_impact	-0.34	0.94	neutral	0.96	neutral	-0.43	0.32	neutral	0.43	0.55	0.12	neutral	0.32	neutral	0.31	neutral	0.45	neutral	1	0.67	neutral	0.49	deleterious	-6	neutral	0.28	neutral	-0.46	medium_impact	-0.03	medium_impact	-1.43	low_impact	0.64	0.8	22.12	15.91	0.45	N	0.13	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14345	14345	T	C	MI.23506	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	329	110	D	G	gAt/gGt	-7.4	0	0	benign	0.02	neutral	0.35	neutral	2.26	neutral	-2.76	neutral	-1.29	neutral_impact	-1	0.96	neutral	0.97	neutral	0.02	2.82	deleterious	0.27	0.45	0.2	neutral	0.48	neutral	0.44	neutral	0.46	neutral	1	0.64	neutral	0.67	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.06	medium_impact	-1.98	low_impact	0.53	0.8	22.12	15.91	0.35	N	0.80	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14345	14345	T	A	MI.23507	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	329	110	D	V	gAt/gTt	-7.4	0	0	possibly_damaging	0.76	neutral	0.48	neutral	2.35	neutral	-2.71	deleterious	-4.33	low_impact	1.06	0.85	neutral	0.87	neutral	2.62	20.30	deleterious	0.27	0.45	0.31	neutral	0.7	disease	0.44	neutral	0.58	disease	2	0.74	neutral	0.36	neutral	-3	neutral	0.58	deleterious	-1.26	low_impact	0.19	medium_impact	-0.25	medium_impact	0.41	0.8	22.12	15.91	0.27	N	0.91	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14345	14345	T	G	MI.23508	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	329	110	D	A	gAt/gCt	-7.4	0	0	benign	0.3	neutral	0.47	neutral	2.3	neutral	-1.72	deleterious	-3.08	low_impact	1.26	0.87	neutral	0.88	neutral	0.56	7.88	deleterious	0.27	0.45	0.18	neutral	0.68	disease	0.53	disease	0.46	neutral	1	0.44	neutral	0.59	deleterious	-6	neutral	0.31	neutral	-0.46	medium_impact	0.18	medium_impact	-0.08	medium_impact	0.64	0.8	22.12	15.91	0.34	N	0.82	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14346	14346	C	T	MI.23509	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	328	110	D	N	Gat/Aat	-2.58	0	0	benign	0.02	neutral	0.35	neutral	2.25	neutral	-2.02	neutral	-1.72	low_impact	0.98	0.91	neutral	0.88	neutral	0.91	10.14	neutral	0.51	0.6	0.17	neutral	0.51	disease	0.34	neutral	0.45	neutral	1	0.64	neutral	0.67	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.06	medium_impact	-0.32	medium_impact	0.73	0.85	22.12	15.91	0.43	N	0.40	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6123	6123	A	T	MI.2351	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	220	74	M	L	Ata/Tta	-2.42	0	0	possibly_damaging	0.9	neutral	0.33	neutral	2.92	neutral	2.07	neutral	-1.35	low_impact	0.96	0.62	neutral	0.86	neutral	2.15	17.16	deleterious	0.47	0.55	0.22	neutral	0.67	disease	0.41	neutral	0.43	neutral	1	0.91	neutral	0.22	neutral	-3	neutral	0.60	deleterious	-1.65	low_impact	0.02	medium_impact	-0.21	medium_impact	0.62	0.9	5.65	8.41	0.39	N	0.61	polymorphism	0.71	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14346	14346	C	A	MI.23510	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	328	110	D	Y	Gat/Tat	-2.58	0	0	probably_damaging	0.91	neutral	1	neutral	2.25	deleterious	-3.72	deleterious	-4.14	low_impact	1.06	0.86	neutral	0.85	neutral	3.03	22.30	deleterious	0.25	0.45	0.45	neutral	0.78	disease	0.4	neutral	0.6	disease	2	0.91	neutral	0.55	deleterious	-2	neutral	0.71	deleterious	-1.72	low_impact	1.87	high_impact	-0.25	medium_impact	0.43	0.8	22.12	15.91	0.24	N	0.95	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14346	14346	C	G	MI.23511	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	328	110	D	H	Gat/Cat	-2.58	0	0	possibly_damaging	0.84	neutral	0.51	neutral	2.22	deleterious	-3.17	deleterious	-3.01	medium_impact	1.96	0.78	neutral	0.63	neutral	2.48	19.34	deleterious	0.34	0.5	0.34	neutral	0.63	disease	0.56	disease	0.71	disease	4	0.82	neutral	0.34	neutral	0	NA	0.61	deleterious	-1.46	low_impact	0.22	medium_impact	0.5	medium_impact	0.56	0.8	22.12	15.91	0.3	N	0.75	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14348	14348	T	C	MI.23512	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	326	109	Y	C	tAt/tGt	-1.44	0	0	benign	0	neutral	0.18	neutral	2.27	deleterious	-5.89	deleterious	-2.74	low_impact	0.87	0.92	neutral	0.73	neutral	0.19	4.56	deleterious	0.3	0.45	0.48	neutral	0.77	disease	0.52	disease	0.68	disease	4	0.82	neutral	0.59	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	-0.16	medium_impact	-0.41	medium_impact	0.16	0.8	49.12	8.75	0.49	N	0.74	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14348	14348	T	G	MI.23513	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	326	109	Y	S	tAt/tCt	-1.44	0	0	benign	0	neutral	0.42	neutral	2.33	deleterious	-4.37	neutral	-0.54	neutral_impact	0.02	0.94	neutral	0.94	neutral	0.43	6.83	deleterious	0.28	0.45	0.12	neutral	0.65	disease	0.51	disease	0.45	neutral	1	0.57	neutral	0.71	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.13	medium_impact	-1.12	low_impact	0.38	0.8	49.12	8.75	0.32	N	0.61	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14348	14348	T	A	MI.23514	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	326	109	Y	F	tAt/tTt	-1.44	0	0	benign	0	neutral	0.7	neutral	2.36	neutral	-1.27	neutral	-1.28	low_impact	0.87	0.94	neutral	0.9	neutral	-0.37	0.45	neutral	0.35	0.5	0.31	neutral	0.44	neutral	0.38	neutral	0.46	neutral	1	0.29	neutral	0.85	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.41	medium_impact	-0.41	medium_impact	0.39	0.8	49.12	8.75	0.33	N	0.43	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14349	14349	A	C	MI.23515	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	325	109	Y	D	Tat/Gat	-3.5	0	0	benign	0.09	neutral	0.22	neutral	2.26	deleterious	-5.81	neutral	-0.43	neutral_impact	-0.56	0.92	neutral	0.86	neutral	0.37	6.32	deleterious	0.3	0.45	0.1	neutral	0.73	disease	0.64	disease	0.58	disease	2	0.75	neutral	0.57	deleterious	-6	neutral	0.17	neutral	0.13	medium_impact	-0.1	medium_impact	-1.61	low_impact	0.39	0.8	49.12	8.75	0.35	N	0.13	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14349	14349	A	G	MI.23516	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	325	109	Y	H	Tat/Cat	-3.5	0	0	possibly_damaging	0.49	neutral	0.53	neutral	2.26	deleterious	-4.31	neutral	-0.33	low_impact	1.15	0.8	neutral	0.86	neutral	1.32	12.39	neutral	0.45	0.55	0.27	neutral	0.62	disease	0.6	disease	0.5	neutral	0	0.47	neutral	0.52	deleterious	-3	neutral	0.42	neutral	-0.78	medium_impact	0.24	medium_impact	-0.18	medium_impact	0.35	0.8	49.12	8.75	0.28	N	0.45	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14349	14349	A	T	MI.23517	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	325	109	Y	N	Tat/Aat	-3.5	0	0	benign	0	neutral	0.32	neutral	2.29	deleterious	-5	neutral	-0.05	neutral_impact	-0.06	0.91	neutral	0.72	neutral	0.21	4.76	deleterious	0.3	0.45	0.13	neutral	0.64	disease	0.51	disease	0.49	neutral	0	0.68	neutral	0.66	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.03	medium_impact	-1.19	low_impact	0.28	0.8	49.12	8.75	0.33	N	0.36	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14350	14350	C	A	MI.23518	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	324	108	E	D	gaG/gaT	-1.21	0	0	benign	0	neutral	0.21	neutral	2.27	neutral	-2.51	neutral	-0.42	neutral_impact	-0.6	0.96	neutral	0.91	neutral	0.86	9.82	deleterious	0.33	0.5	0.23	neutral	0.25	neutral	0.34	neutral	0.43	neutral	1	0.79	neutral	0.61	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	-0.11	medium_impact	-1.64	low_impact	0.80	0.85	47.79	8.45	0.48	N	0.13	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14350	14350	C	G	MI.23519	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	324	108	E	D	gaG/gaC	-1.21	0	0	benign	0	neutral	0.21	neutral	2.27	neutral	-2.51	neutral	-0.42	neutral_impact	-0.6	0.96	neutral	0.91	neutral	0.62	8.32	deleterious	0.33	0.5	0.23	neutral	0.25	neutral	0.34	neutral	0.43	neutral	1	0.79	neutral	0.61	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	-0.11	medium_impact	-1.64	low_impact	0.80	0.85	47.79	8.45	0.52	N	0.13	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6123	6123	A	C	MI.2352	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	220	74	M	L	Ata/Cta	-2.42	0	0	possibly_damaging	0.9	neutral	0.33	neutral	2.92	neutral	2.07	neutral	-1.35	low_impact	0.96	0.62	neutral	0.86	neutral	2.08	16.70	deleterious	0.47	0.55	0.22	neutral	0.67	disease	0.41	neutral	0.43	neutral	1	0.91	neutral	0.22	neutral	-3	neutral	0.60	deleterious	-1.65	low_impact	0.02	medium_impact	-0.21	medium_impact	0.62	0.9	5.65	8.41	0.39	N	0.61	polymorphism	0.71	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14351	14351	T	A	MI.23520	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	323	108	E	V	gAg/gTg	-5.33	0	0	benign	0.18	neutral	0.51	neutral	2.32	neutral	-1.04	neutral	-0.75	neutral_impact	-0.1	0.9	neutral	0.93	neutral	1.18	11.64	neutral	0.25	0.45	0.14	neutral	0.37	neutral	0.54	disease	0.46	neutral	1	0.39	neutral	0.67	deleterious	-6	neutral	0.25	neutral	-0.19	medium_impact	0.22	medium_impact	-1.22	low_impact	0.72	0.85	47.79	8.45	0.31	N	0.31	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14351	14351	T	G	MI.23521	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	323	108	E	A	gAg/gCg	-5.33	0	0	benign	0.09	neutral	0.51	neutral	2.33	neutral	-1.67	neutral	-0.28	low_impact	1.15	0.86	neutral	0.88	neutral	0.27	5.40	deleterious	0.28	0.45	0.15	neutral	0.37	neutral	0.53	disease	0.46	neutral	1	0.42	neutral	0.71	deleterious	-6	neutral	0.15	neutral	0.13	medium_impact	0.22	medium_impact	-0.18	medium_impact	0.72	0.85	47.79	8.45	0.31	N	0.11	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14351	14351	T	C	MI.23522	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	323	108	E	G	gAg/gGg	-5.33	0	0	benign	0.14	neutral	0.35	neutral	2.29	deleterious	-3	neutral	-0.18	neutral_impact	-0.26	0.97	neutral	0.97	neutral	0.73	9.00	deleterious	0.35	0.5	0.18	neutral	0.22	neutral	0.5	neutral	0.36	neutral	3	0.59	neutral	0.61	deleterious	-6	neutral	0.18	neutral	-0.07	medium_impact	0.06	medium_impact	-1.36	low_impact	0.75	0.85	47.79	8.45	0.43	N	0.01	NA	NA	0.16	.	.	.	.	.	.	COSM1155555	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14352	14352	C	T	MI.23523	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	322	108	E	K	Gag/Aag	-4.19	0	0	benign	0.14	neutral	0.3	neutral	2.32	neutral	-1.79	neutral	0.42	neutral_impact	-0.07	0.86	neutral	0.92	neutral	1.37	12.64	neutral	0.29	0.45	0.1	neutral	0.36	neutral	0.54	disease	0.46	neutral	1	0.65	neutral	0.58	deleterious	-6	neutral	0.23	neutral	-0.07	medium_impact	0	medium_impact	-1.2	low_impact	0.79	0.85	47.79	8.45	0.34	N	0.22	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14352	14352	C	G	MI.23524	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	322	108	E	Q	Gag/Cag	-4.19	0	0	benign	0.34	neutral	0.3	neutral	2.31	neutral	-2.29	neutral	-0.16	low_impact	1.15	0.86	neutral	0.78	neutral	0.52	7.58	deleterious	0.39	0.5	0.19	neutral	0.2	neutral	0.49	neutral	0.39	neutral	2	0.64	neutral	0.48	deleterious	-6	neutral	0.33	neutral	-0.53	medium_impact	0	medium_impact	-0.18	medium_impact	0.75	0.85	47.79	8.45	0.43	N	0.13	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14353	14353	T	A	MI.23525	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	321	107	K	N	aaA/aaT	-3.5	0	0	benign	0.14	neutral	0.33	neutral	2.32	neutral	-2.54	neutral	-0.23	neutral_impact	0.49	0.84	neutral	0.92	neutral	0.88	9.98	deleterious	0.55	0.6	0.14	neutral	0.24	neutral	0.3	neutral	0.42	neutral	2	0.61	neutral	0.6	deleterious	-6	neutral	0.21	neutral	-0.07	medium_impact	0.04	medium_impact	-0.73	medium_impact	0.74	0.85	48.67	8.6	0.44	N	0.27	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14353	14353	T	G	MI.23526	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	321	107	K	N	aaA/aaC	-3.5	0	0	benign	0.14	neutral	0.33	neutral	2.32	neutral	-2.54	neutral	-0.23	neutral_impact	0.49	0.84	neutral	0.92	neutral	0.66	8.57	deleterious	0.55	0.6	0.14	neutral	0.24	neutral	0.3	neutral	0.42	neutral	2	0.61	neutral	0.6	deleterious	-6	neutral	0.21	neutral	-0.07	medium_impact	0.04	medium_impact	-0.73	medium_impact	0.74	0.85	48.67	8.6	0.41	N	0.27	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14354	14354	T	A	MI.23527	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	320	107	K	M	aAa/aTa	-3.04	0	0	benign	0.04	neutral	0.22	neutral	2.36	deleterious	-3.8	neutral	2.27	neutral_impact	-0.9	0.91	neutral	0.91	neutral	0.89	10.04	neutral	0.24	0.45	0.4	neutral	0.15	neutral	0.3	neutral	0.32	neutral	4	0.77	neutral	0.59	deleterious	-6	neutral	0.17	neutral	0.47	medium_impact	-0.1	medium_impact	-1.89	low_impact	0.51	0.8	48.67	8.6	0.46	N	0.51	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14354	14354	T	G	MI.23528	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	320	107	K	T	aAa/aCa	-3.04	0	0	benign	0.14	neutral	0.41	neutral	2.35	neutral	-1.32	neutral	0.54	neutral_impact	0.34	0.81	neutral	0.8	neutral	0.49	7.35	deleterious	0.25	0.45	0.16	neutral	0.2	neutral	0.4	neutral	0.37	neutral	3	0.52	neutral	0.64	deleterious	-6	neutral	0.22	neutral	-0.07	medium_impact	0.12	medium_impact	-0.86	medium_impact	0.60	0.8	48.67	8.6	0.34	N	0.37	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14355	14355	T	G	MI.23529	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	319	107	K	Q	Aaa/Caa	-0.06	0	0	benign	0.34	neutral	0.31	neutral	2.3	neutral	-2.2	neutral	-0.1	low_impact	1.04	0.82	neutral	0.67	neutral	0.60	8.18	deleterious	0.4	0.5	0.19	neutral	0.19	neutral	0.4	neutral	0.38	neutral	2	0.63	neutral	0.49	deleterious	-6	neutral	0.36	neutral	-0.53	medium_impact	0.01	medium_impact	-0.27	medium_impact	0.71	0.85	48.67	8.6	0.43	N	0.50	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6124	6124	T	A	MI.2353	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	221	74	M	K	aTa/aAa	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-1.79	deleterious	-3.66	high_impact	4.72	0.59	damaging	0.11	damaging	3.90	23.50	deleterious	0.23	0.55	0.59	disease	0.97	disease	0.73	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.72	0.9	5.65	8.41	0.71	P	0.93	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14355	14355	T	C	MI.23530	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	319	107	K	E	Aaa/Gaa	-0.06	0	0	benign	0.14	neutral	0.31	neutral	2.31	neutral	-1.8	neutral	-0.5	neutral_impact	0.69	0.88	neutral	0.88	neutral	0.52	7.60	deleterious	0.32	0.5	0.15	neutral	0.41	neutral	0.35	neutral	0.43	neutral	1	0.64	neutral	0.59	deleterious	-6	neutral	0.23	neutral	-0.07	medium_impact	0.01	medium_impact	-0.56	medium_impact	0.76	0.85	48.67	8.6	0.42	N	0.54	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14357	14357	A	C	MI.23531	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	317	106	V	G	gTg/gGg	-5.79	0	0	benign	0.21	neutral	0.33	neutral	2.45	deleterious	-4.92	deleterious	-3.65	low_impact	1.34	0.84	neutral	0.89	neutral	0.24	5.11	deleterious	0.33	0.5	0.42	neutral	0.3	neutral	0.56	disease	0.47	neutral	1	0.6	neutral	0.56	deleterious	-6	neutral	0.28	neutral	-0.27	medium_impact	0.04	medium_impact	-0.02	medium_impact	0.78	0.85	42.48	7.64	0.42	N	0.80	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14357	14357	A	T	MI.23532	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	317	106	V	E	gTg/gAg	-5.79	0	0	benign	0.4	neutral	0.28	neutral	2.27	deleterious	-5.41	deleterious	-3.47	medium_impact	2	0.82	neutral	0.69	neutral	1.35	12.52	neutral	0.22	0.45	0.43	neutral	0.7	disease	0.71	disease	0.63	disease	3	0.67	neutral	0.44	neutral	-3	neutral	0.43	neutral	-0.64	medium_impact	-0.02	medium_impact	0.54	medium_impact	0.76	0.85	42.48	7.64	0.32	N	0.82	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14357	14357	A	G	MI.23533	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	317	106	V	A	gTg/gCg	-5.79	0	0	benign	0.01	neutral	0.51	neutral	2.33	deleterious	-3.33	neutral	-1.9	low_impact	0.92	0.95	neutral	0.95	neutral	0.18	4.51	deleterious	0.43	0.55	0.17	neutral	0.41	neutral	0.56	disease	0.46	neutral	1	0.48	neutral	0.75	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.22	medium_impact	-0.37	medium_impact	0.84	0.9	42.48	7.64	0.3	N	0.44	NA	NA	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14358	14358	C	G	MI.23534	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	316	106	V	L	Gtg/Ctg	-0.06	0	0	benign	0	neutral	0.65	neutral	2.41	neutral	-2.77	neutral	0.15	neutral_impact	-0.12	0.94	neutral	0.91	neutral	-0.39	0.40	neutral	0.39	0.5	0.12	neutral	0.29	neutral	0.29	neutral	0.43	neutral	1	0.34	neutral	0.83	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.36	medium_impact	-1.24	low_impact	0.87	0.9	42.48	7.64	0.33	N	0.38	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14358	14358	C	T	MI.23535	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	316	106	V	M	Gtg/Atg	-0.06	0	0	benign	0.03	neutral	0.22	neutral	2.25	deleterious	-4.51	neutral	0.48	neutral_impact	0.55	0.87	neutral	0.95	neutral	0.28	5.53	deleterious	0.49	0.55	0.2	neutral	0.2	neutral	0.38	neutral	0.36	neutral	3	0.77	neutral	0.6	deleterious	-6	neutral	0.12	neutral	0.59	medium_impact	-0.1	medium_impact	-0.68	medium_impact	0.84	0.9	42.48	7.64	0.48	N	0.55	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14358	14358	C	A	MI.23536	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	316	106	V	L	Gtg/Ttg	-0.06	0	0	benign	0	neutral	0.65	neutral	2.41	neutral	-2.77	neutral	0.15	neutral_impact	-0.12	0.94	neutral	0.91	neutral	-0.10	1.76	neutral	0.39	0.5	0.12	neutral	0.29	neutral	0.29	neutral	0.43	neutral	1	0.34	neutral	0.83	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.36	medium_impact	-1.24	low_impact	0.87	0.9	42.48	7.64	0.39	N	0.38	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14359	14359	C	A	MI.23537	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	315	105	W	C	tgG/tgT	-2.81	0	0	probably_damaging	0.96	neutral	0.2	neutral	2.33	deleterious	-4.42	deleterious	-5.93	medium_impact	2.02	0.87	neutral	0.83	neutral	3.50	23.10	deleterious	0.42	0.55	0.66	disease	0.81	disease	0.62	disease	0.63	disease	3	0.97	neutral	0.12	neutral	1	deleterious	0.80	deleterious	-2.06	low_impact	-0.13	medium_impact	0.55	medium_impact	0.43	0.8	49.12	8.67	0.36	N	0.78	NA	NA	0.65	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14359	14359	C	G	MI.23538	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	315	105	W	C	tgG/tgC	-2.81	0	0	probably_damaging	0.96	neutral	0.2	neutral	2.33	deleterious	-4.42	deleterious	-5.93	medium_impact	2.02	0.87	neutral	0.83	neutral	3.06	22.40	deleterious	0.42	0.55	0.66	disease	0.81	disease	0.62	disease	0.63	disease	3	0.97	neutral	0.12	neutral	1	deleterious	0.80	deleterious	-2.06	low_impact	-0.13	medium_impact	0.55	medium_impact	0.43	0.8	49.12	8.67	0.37	N	0.78	NA	NA	0.65	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14360	14360	C	A	MI.23539	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	314	105	W	L	tGg/tTg	-2.35	0	0	benign	0.02	neutral	0.95	neutral	2.69	neutral	-0.81	deleterious	-5.14	neutral_impact	0.27	0.94	neutral	0.89	neutral	2.63	20.40	deleterious	0.35	0.5	0.13	neutral	0.64	disease	0.49	neutral	0.46	neutral	1	0.01	neutral	0.97	deleterious	-6	neutral	0.16	neutral	0.75	medium_impact	0.92	medium_impact	-0.91	medium_impact	0.35	0.8	49.12	8.67	0.29	N	0.48	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6124	6124	T	C	MI.2354	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	221	74	M	T	aTa/aCa	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-0.36	deleterious	-3.5	medium_impact	3.13	0.63	neutral	0.14	damaging	2.89	21.80	deleterious	0.37	0.55	0.4	neutral	0.92	disease	0.52	disease	0.67	disease	3	1	deleterious	0	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	1.79	medium_impact	0.54	0.9	5.65	8.41	0.42	N	0.79	disease_causing	0.94	0.11	.	.	.	.	.	prostate tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14360	14360	C	G	MI.23540	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	314	105	W	S	tGg/tCg	-2.35	0	0	possibly_damaging	0.82	neutral	0.53	neutral	2.4	neutral	-2.94	deleterious	-6.64	low_impact	1.79	0.86	neutral	0.87	neutral	3.02	22.30	deleterious	0.3	0.45	0.44	neutral	0.81	disease	0.66	disease	0.6	disease	2	0.8	neutral	0.36	neutral	-3	neutral	0.72	deleterious	-1.4	low_impact	0.24	medium_impact	0.36	medium_impact	0.42	0.8	49.12	8.67	0.23	N	0.80	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14361	14361	A	C	MI.23541	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	313	105	W	G	Tgg/Ggg	-0.52	0	0	possibly_damaging	0.73	neutral	0.42	neutral	2.34	deleterious	-3.89	deleterious	-6.69	low_impact	1.55	0.81	neutral	0.81	neutral	2.52	19.60	deleterious	0.32	0.5	0.58	disease	0.74	disease	0.69	disease	0.61	disease	2	0.73	neutral	0.35	neutral	-3	neutral	0.69	deleterious	-1.19	low_impact	0.13	medium_impact	0.16	medium_impact	0.54	0.8	49.12	8.67	0.27	N	0.69	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14361	14361	A	G	MI.23542	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	313	105	W	R	Tgg/Cgg	-0.52	0	0	probably_damaging	0.91	neutral	0.33	neutral	2.32	deleterious	-3.52	deleterious	-6.87	medium_impact	2.83	0.78	neutral	0.49	neutral	2.68	20.70	deleterious	0.45	0.55	0.55	disease	0.83	disease	0.73	disease	0.79	disease	6	0.92	neutral	0.21	neutral	1	deleterious	0.78	deleterious	-1.72	low_impact	0.04	medium_impact	1.23	medium_impact	0.45	0.8	49.12	8.67	0.29	N	0.84	NA	NA	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14363	14363	A	T	MI.23543	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	311	104	L	Q	cTg/cAg	-6.48	0	0	probably_damaging	0.91	neutral	0.28	neutral	2	deleterious	-3.2	deleterious	-3.23	medium_impact	2.83	0.78	neutral	0.49	neutral	3.55	23.10	deleterious	0.21	0.45	0.49	neutral	0.69	disease	0.5	neutral	0.53	disease	1	0.93	neutral	0.19	neutral	1	deleterious	0.72	deleterious	-1.72	low_impact	-0.02	medium_impact	1.23	medium_impact	0.81	0.85	48.23	8.5	0.33	N	0.62	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14363	14363	A	G	MI.23544	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	311	104	L	P	cTg/cCg	-6.48	0	0	probably_damaging	0.91	neutral	0.21	neutral	2.02	deleterious	-4	deleterious	-4.17	medium_impact	2.48	0.73	neutral	0.4	neutral	3.79	23.40	deleterious	0.16	0.45	0.56	disease	0.89	disease	0.51	disease	0.75	disease	5	0.94	neutral	0.15	neutral	1	deleterious	0.80	deleterious	-1.72	low_impact	-0.11	medium_impact	0.94	medium_impact	0.72	0.85	48.23	8.5	0.32	N	0.84	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14363	14363	A	C	MI.23545	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	311	104	L	R	cTg/cGg	-6.48	0	0	probably_damaging	0.91	neutral	0.34	neutral	2.01	neutral	-1.74	deleterious	-3.68	medium_impact	2.48	0.73	neutral	0.43	neutral	2.62	20.30	deleterious	0.18	0.45	0.47	neutral	0.85	disease	0.62	disease	0.78	disease	6	0.92	neutral	0.22	neutral	1	deleterious	0.78	deleterious	-1.72	low_impact	0.05	medium_impact	0.94	medium_impact	0.83	0.9	48.23	8.5	0.33	N	0.63	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14364	14364	G	C	MI.23546	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	310	104	L	V	Ctg/Gtg	-0.52	0	0.1	benign	0.05	neutral	0.58	neutral	2.09	neutral	-1.35	neutral	-0.56	neutral_impact	0.69	0.9	neutral	0.98	neutral	1.11	11.28	neutral	0.43	0.55	0.13	neutral	0.34	neutral	0.27	neutral	0.45	neutral	1	0.36	neutral	0.77	deleterious	-6	neutral	0.15	neutral	0.38	medium_impact	0.28	medium_impact	-0.56	medium_impact	0.85	0.9	48.23	8.5	0.39	N	0.32	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14364	14364	G	T	MI.23547	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	310	104	L	M	Ctg/Atg	-0.52	0	0.1	benign	0.26	neutral	0.26	neutral	2.03	neutral	-2.73	neutral	-0.16	low_impact	1.03	0.86	neutral	0.99	neutral	1.86	15.36	deleterious	0.33	0.5	0.33	neutral	0.28	neutral	0.32	neutral	0.45	neutral	1	0.69	neutral	0.5	deleterious	-6	neutral	0.24	neutral	-0.38	medium_impact	-0.05	medium_impact	-0.28	medium_impact	0.68	0.85	48.23	8.5	0.49	N	0.41	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14366	14366	A	C	MI.23548	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	308	103	V	G	gTg/gGg	-2.81	0	0	probably_damaging	0.96	neutral	0.36	neutral	2.25	deleterious	-3.02	deleterious	-5.76	low_impact	1.64	0.85	neutral	0.75	neutral	3.53	23.10	deleterious	0.31	0.45	0.33	neutral	0.68	disease	0.48	neutral	0.49	neutral	0	0.96	neutral	0.2	neutral	-2	neutral	0.70	deleterious	-2.06	low_impact	0.07	medium_impact	0.23	medium_impact	0.84	0.9	22.12	23.58	0.29	N	0.75	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14366	14366	A	T	MI.23549	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	308	103	V	E	gTg/gAg	-2.81	0	0	probably_damaging	0.97	neutral	0.3	neutral	2.18	deleterious	-3.09	deleterious	-5.02	medium_impact	2.98	0.81	neutral	0.74	neutral	4.36	24.10	deleterious	0.23	0.45	0.52	disease	0.84	disease	0.66	disease	0.64	disease	3	0.98	neutral	0.17	neutral	1	deleterious	0.81	deleterious	-2.18	low_impact	0	medium_impact	1.36	medium_impact	0.90	0.95	22.12	23.58	0.3	N	0.83	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6125	6125	A	T	MI.2355	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	222	74	M	I	atA/atT	7.53	1	0.01	probably_damaging	0.96	deleterious	0	neutral	2.87	neutral	0.66	neutral	-2.05	medium_impact	3.34	0.59	damaging	0.14	damaging	3.39	23.00	deleterious	0.47	0.55	0.24	neutral	0.95	disease	0.57	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-2.06	low_impact	-1.48	low_impact	1.99	medium_impact	0.67	0.9	5.65	8.41	0.49	P	0.87	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14366	14366	A	G	MI.23550	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	308	103	V	A	gTg/gCg	-2.81	0	0	possibly_damaging	0.69	neutral	0.52	neutral	2.35	neutral	-1.83	deleterious	-3.05	low_impact	1.63	0.92	neutral	0.98	neutral	2.34	18.43	deleterious	0.41	0.5	0.23	neutral	0.57	disease	0.43	neutral	0.45	neutral	1	0.66	neutral	0.42	neutral	-3	neutral	0.58	deleterious	-1.11	low_impact	0.23	medium_impact	0.23	medium_impact	0.86	0.9	22.12	23.58	0.33	N	0.21	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14367	14367	C	T	MI.23551	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	307	103	V	M	Gtg/Atg	-0.29	0	0	probably_damaging	0.92	neutral	0.23	neutral	2.38	neutral	-2.71	neutral	-1.71	low_impact	1.78	0.9	neutral	0.96	neutral	2.62	20.30	deleterious	0.49	0.55	0.38	neutral	0.43	neutral	0.4	neutral	0.45	neutral	1	0.94	neutral	0.16	neutral	-2	neutral	0.67	deleterious	-1.77	low_impact	-0.09	medium_impact	0.35	medium_impact	0.87	0.9	22.12	23.58	0.49	N	0.54	NA	NA	0.37	.	.	.	.	.	.	COSM6716805	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14367	14367	C	G	MI.23552	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	307	103	V	L	Gtg/Ctg	-0.29	0	0	benign	0.06	neutral	0.67	neutral	2.34	neutral	-0.88	neutral	-1.54	low_impact	1.28	0.85	neutral	0.94	neutral	0.89	9.99	deleterious	0.44	0.55	0.16	neutral	0.46	neutral	0.45	neutral	0.45	neutral	1	0.25	neutral	0.81	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	0.38	medium_impact	-0.07	medium_impact	0.89	0.9	22.12	23.58	0.29	N	0.35	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14367	14367	C	A	MI.23553	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	307	103	V	L	Gtg/Ttg	-0.29	0	0	benign	0.06	neutral	0.67	neutral	2.34	neutral	-0.88	neutral	-1.54	low_impact	1.28	0.85	neutral	0.94	neutral	1.23	11.92	neutral	0.44	0.55	0.16	neutral	0.46	neutral	0.45	neutral	0.45	neutral	1	0.25	neutral	0.81	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	0.38	medium_impact	-0.07	medium_impact	0.89	0.9	22.12	23.58	0.29	N	0.35	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14368	14368	C	A	MI.23554	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	306	102	L	F	ttG/ttT	-2.35	0	0	possibly_damaging	0.89	neutral	0.76	neutral	2.57	neutral	-1.78	neutral	-2.49	low_impact	1.47	0.85	neutral	0.97	neutral	2.82	21.50	deleterious	0.47	0.55	0.33	neutral	0.33	neutral	0.3	neutral	0.46	neutral	1	0.87	neutral	0.44	neutral	-3	neutral	0.65	deleterious	-1.63	low_impact	0.48	medium_impact	0.09	medium_impact	0.77	0.85	18.14	17.58	0.26	N	0.34	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14368	14368	C	G	MI.23555	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	306	102	L	F	ttG/ttC	-2.35	0	0	possibly_damaging	0.89	neutral	0.76	neutral	2.57	neutral	-1.78	neutral	-2.49	low_impact	1.47	0.85	neutral	0.97	neutral	2.34	18.45	deleterious	0.47	0.55	0.33	neutral	0.33	neutral	0.3	neutral	0.46	neutral	1	0.87	neutral	0.44	neutral	-3	neutral	0.65	deleterious	-1.63	low_impact	0.48	medium_impact	0.09	medium_impact	0.77	0.85	18.14	17.58	0.26	N	0.34	NA	NA	0.52	rs2853816	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14369	14369	A	C	MI.23556	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	305	102	L	W	tTg/tGg	-9.92	0	0	probably_damaging	0.98	neutral	0.19	neutral	2.11	deleterious	-3.67	deleterious	-4.27	medium_impact	2.19	0.91	neutral	0.94	neutral	2.31	18.20	deleterious	0.2	0.45	0.66	disease	0.58	disease	0.38	neutral	0.52	disease	0	0.99	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-2.35	low_impact	-0.14	medium_impact	0.7	medium_impact	0.72	0.85	18.14	17.58	0.45	N	0.47	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14369	14369	A	G	MI.23557	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	305	102	L	S	tTg/tCg	-9.92	0	0	possibly_damaging	0.87	neutral	0.43	neutral	2.15	neutral	-1.86	deleterious	-3.67	medium_impact	1.99	0.83	neutral	0.86	neutral	3.77	23.40	deleterious	0.29	0.45	0.29	neutral	0.5	neutral	0.49	neutral	0.46	neutral	1	0.87	neutral	0.28	neutral	0	NA	0.67	deleterious	-1.55	low_impact	0.14	medium_impact	0.53	medium_impact	0.84	0.9	18.14	17.58	0.33	N	0.58	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14370	14370	A	C	MI.23558	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	304	102	L	V	Ttg/Gtg	0.63	0	0	benign	0.1	neutral	0.55	neutral	2.24	neutral	-2.13	neutral	-0.87	neutral_impact	0.25	0.94	neutral	0.99	neutral	-0.78	0.05	neutral	0.44	0.55	0.13	neutral	0.17	neutral	0.27	neutral	0.26	neutral	5	0.37	neutral	0.73	deleterious	-6	neutral	0.16	neutral	0.08	medium_impact	0.26	medium_impact	-0.93	medium_impact	0.84	0.9	18.14	17.58	0.41	N	0.25	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14370	14370	A	T	MI.23559	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	304	102	L	M	Ttg/Atg	0.63	0	0	benign	0.24	neutral	0.25	neutral	2.16	neutral	-2.59	neutral	-0.46	neutral_impact	0.72	0.94	neutral	0.97	neutral	1.07	11.06	neutral	0.33	0.5	0.22	neutral	0.18	neutral	0.33	neutral	0.3	neutral	4	0.7	neutral	0.51	deleterious	-6	neutral	0.30	neutral	-0.34	medium_impact	-0.06	medium_impact	-0.54	medium_impact	0.77	0.85	18.14	17.58	0.56	P	0.17	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6125	6125	A	C	MI.2356	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	222	74	M	I	atA/atC	7.53	1	0.01	probably_damaging	0.96	deleterious	0	neutral	2.87	neutral	0.66	neutral	-2.05	medium_impact	3.34	0.59	damaging	0.14	damaging	3.34	22.90	deleterious	0.47	0.55	0.24	neutral	0.95	disease	0.57	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-2.06	low_impact	-1.48	low_impact	1.99	medium_impact	0.67	0.9	5.65	8.41	0.49	P	0.87	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14372	14372	C	T	MI.23560	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	302	101	G	E	gGa/gAa	-9	0	0	benign	0	neutral	0.3	neutral	2.27	neutral	-0.47	neutral	-0.52	low_impact	1.65	0.72	neutral	0.45	neutral	2.69	20.70	deleterious	0.3	0.45	0.3	neutral	0.83	disease	0.66	disease	0.76	disease	5	0.7	neutral	0.65	deleterious	-6	neutral	0.24	neutral	1.95	medium_impact	0	medium_impact	0.24	medium_impact	0.75	0.85	49.56	8.63	0.31	N	0.67	NA	NA	0.20	rs386829210	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14372	14372	C	A	MI.23561	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	302	101	G	V	gGa/gTa	-9	0	0	benign	0	neutral	0.54	neutral	2.4	neutral	-1.97	neutral	2.72	neutral_impact	-0.77	0.93	neutral	0.93	neutral	0.22	4.84	deleterious	0.22	0.45	0.09	neutral	0.65	disease	0.32	neutral	0.43	neutral	1	0.46	neutral	0.77	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.25	medium_impact	-1.79	low_impact	0.71	0.85	49.56	8.63	0.22	N	0.31	NA	NA	0.16	rs386829210	Uncertain_significance	Acute_megakaryoblastic_leukemia|Mediastinal_germ_cell_tumor	215055	MeSH:D007947,MedGen:C0023462,Orphanet:ORPHA518|MedGen:C1334655	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14372	14372	C	G	MI.23562	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	302	101	G	A	gGa/gCa	-9	0	0	benign	0	neutral	0.54	neutral	2.34	neutral	-0.87	neutral	1.21	neutral_impact	0.2	0.85	neutral	0.93	neutral	0.05	3.07	deleterious	0.46	0.55	0.12	neutral	0.57	disease	0.44	neutral	0.45	neutral	1	0.45	neutral	0.77	deleterious	-6	neutral	0.15	neutral	1.95	medium_impact	0.25	medium_impact	-0.97	medium_impact	0.77	0.85	49.56	8.63	0.31	N	0.33	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14373	14373	C	A	MI.23563	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	301	101	G	W	Gga/Tga	-0.52	0	0	possibly_damaging	0.7	neutral	0.19	neutral	2.26	deleterious	-4.73	neutral	0.26	low_impact	1.3	0.83	neutral	0.52	neutral	3.54	23.10	deleterious	0.21	0.45	0.53	disease	0.87	disease	0.53	disease	0.76	disease	5	0.85	neutral	0.25	neutral	-3	neutral	0.65	deleterious	-1.13	low_impact	-0.14	medium_impact	-0.05	medium_impact	0.55	0.8	49.56	8.63	0.4	N	0.56	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14373	14373	C	G	MI.23564	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	301	101	G	R	Gga/Cga	-0.52	0	0	benign	0.18	neutral	0.35	neutral	2.27	neutral	-1.21	neutral	-0.3	low_impact	1.65	0.77	neutral	0.38	neutral	2.72	20.90	deleterious	0.21	0.45	0.3	neutral	0.82	disease	0.68	disease	0.76	disease	5	0.58	neutral	0.59	deleterious	-6	neutral	0.41	neutral	-0.19	medium_impact	0.06	medium_impact	0.24	medium_impact	0.81	0.85	49.56	8.63	0.28	N	0.58	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14375	14375	A	T	MI.23565	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	299	100	V	E	gTa/gAa	-12.67	0	0	possibly_damaging	0.5	neutral	0.35	neutral	2.13	deleterious	-4.15	deleterious	-3.58	medium_impact	2.6	0.84	neutral	0.47	neutral	4.44	24.20	deleterious	0.19	0.45	0.72	disease	0.84	disease	0.71	disease	0.8	disease	6	0.63	neutral	0.43	neutral	0	NA	0.54	deleterious	-0.8	medium_impact	0.06	medium_impact	1.04	medium_impact	0.54	0.8	27.43	8.87	0.29	N	0.88	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14375	14375	A	G	MI.23566	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	299	100	V	A	gTa/gCa	-12.67	0	0	benign	0.01	neutral	0.47	neutral	2.25	neutral	-2.23	neutral	-1.85	low_impact	1.7	0.94	neutral	0.85	neutral	1.05	10.92	neutral	0.3	0.45	0.42	neutral	0.47	neutral	0.53	disease	0.49	neutral	0	0.52	neutral	0.73	deleterious	-6	neutral	0.18	neutral	1.03	medium_impact	0.18	medium_impact	0.28	medium_impact	0.54	0.8	27.43	8.87	0.44	N	0.46	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14375	14375	A	C	MI.23567	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	299	100	V	G	gTa/gGa	-12.67	0	0	benign	0.3	neutral	0.4	neutral	2.2	deleterious	-4.38	deleterious	-3.77	low_impact	1.24	0.88	neutral	0.84	neutral	0.89	10.04	neutral	0.26	0.45	0.71	disease	0.62	disease	0.55	disease	0.53	disease	1	0.52	neutral	0.55	deleterious	-6	neutral	0.38	neutral	-0.46	medium_impact	0.11	medium_impact	-0.1	medium_impact	0.56	0.8	27.43	8.87	0.41	N	0.84	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14376	14376	C	G	MI.23568	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	298	100	V	L	Gta/Cta	-0.06	0	0	benign	0.01	neutral	1	neutral	2.41	neutral	-0.72	neutral	0.63	neutral_impact	0.46	0.86	neutral	0.91	neutral	-0.78	0.05	neutral	0.43	0.55	0.14	neutral	0.34	neutral	0.29	neutral	0.44	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	1.87	high_impact	-0.76	medium_impact	0.76	0.85	27.43	8.87	0.28	N	0.32	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14376	14376	C	A	MI.23569	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	298	100	V	L	Gta/Tta	-0.06	0	0	benign	0.01	neutral	1	neutral	2.41	neutral	-0.72	neutral	0.63	neutral_impact	0.46	0.86	neutral	0.91	neutral	-0.45	0.29	neutral	0.43	0.55	0.14	neutral	0.34	neutral	0.29	neutral	0.44	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	1.87	high_impact	-0.76	medium_impact	0.76	0.85	27.43	8.87	0.28	N	0.32	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6126	6126	A	G	MI.2357	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	223	75	I	V	Atc/Gtc	-1.26	0	0	probably_damaging	0.92	deleterious	0	neutral	2.87	neutral	-0.63	neutral	-0.61	medium_impact	2.26	0.51	damaging	0.43	neutral	2.97	22.10	deleterious	0.62	0.65	0.28	neutral	0.47	neutral	0.36	neutral	0.41	neutral	2	1	deleterious	0.04	neutral	5	deleterious	0.63	deleterious	-1.76	low_impact	-1.48	low_impact	0.99	medium_impact	0.50	0.9	10.92	16.76	0.5	N	0.23	disease_causing	0.93	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14376	14376	C	T	MI.23570	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	298	100	V	M	Gta/Ata	-0.06	0	0	benign	0.09	neutral	0.28	neutral	2.18	neutral	-2.63	neutral	0.03	low_impact	1.21	0.93	neutral	0.87	neutral	0.71	8.89	deleterious	0.39	0.5	0.43	neutral	0.36	neutral	0.42	neutral	0.46	neutral	1	0.69	neutral	0.6	deleterious	-6	neutral	0.20	neutral	0.13	medium_impact	-0.02	medium_impact	-0.13	medium_impact	0.80	0.85	27.43	8.87	0.54	N	0.56	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14377	14377	C	A	MI.23571	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	297	99	E	D	gaG/gaT	-3.27	0	0	probably_damaging	1	neutral	0.19	neutral	2.3	neutral	1.11	deleterious	-2.95	medium_impact	3.49	0.82	neutral	0.23	damaging	4.24	23.90	deleterious	0.33	0.5	0.29	neutral	0.4	neutral	0.58	disease	0.48	neutral	0	1	deleterious	0.1	neutral	1	deleterious	0.68	deleterious	-3.55	low_impact	-0.14	medium_impact	1.78	medium_impact	0.81	0.85	43.36	8.06	0.31	N	0.83	NA	NA	0.53	rs56407536	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14377	14377	C	G	MI.23572	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	297	99	E	D	gaG/gaC	-3.27	0	0	probably_damaging	1	neutral	0.19	neutral	2.3	neutral	1.11	deleterious	-2.95	medium_impact	3.49	0.82	neutral	0.23	damaging	3.84	23.40	deleterious	0.33	0.5	0.29	neutral	0.4	neutral	0.58	disease	0.48	neutral	0	1	deleterious	0.1	neutral	1	deleterious	0.68	deleterious	-3.55	low_impact	-0.14	medium_impact	1.78	medium_impact	0.81	0.85	43.36	8.06	0.4	N	0.83	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14378	14378	T	A	MI.23573	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	296	99	E	V	gAg/gTg	-3.5	0	0	probably_damaging	1	neutral	0.91	neutral	2.49	neutral	2.68	deleterious	-6.66	medium_impact	2.29	0.81	neutral	0.31	neutral	4.58	24.40	deleterious	0.21	0.45	0.27	neutral	0.35	neutral	0.38	neutral	0.45	neutral	1	1	deleterious	0.46	neutral	1	deleterious	0.68	deleterious	-3.55	low_impact	0.76	medium_impact	0.78	medium_impact	0.70	0.85	43.36	8.06	0.27	N	0.72	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14378	14378	T	G	MI.23574	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	296	99	E	A	gAg/gCg	-3.5	0	0	probably_damaging	1	neutral	0.55	neutral	2.41	neutral	3.25	deleterious	-5.84	medium_impact	2.68	0.78	neutral	0.43	neutral	4.05	23.70	deleterious	0.22	0.45	0.22	neutral	0.38	neutral	0.57	disease	0.47	neutral	1	1	deleterious	0.28	neutral	1	deleterious	0.68	deleterious	-3.55	low_impact	0.26	medium_impact	1.11	medium_impact	0.70	0.85	43.36	8.06	0.32	N	0.64	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14378	14378	T	C	MI.23575	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	296	99	E	G	gAg/gGg	-3.5	0	0	probably_damaging	1	neutral	0.38	neutral	2.33	neutral	3.54	deleterious	-6.78	medium_impact	2.52	0.8	neutral	0.35	neutral	4.16	23.80	deleterious	0.29	0.45	0.25	neutral	0.25	neutral	0.61	disease	0.46	neutral	1	1	deleterious	0.19	neutral	1	deleterious	0.67	deleterious	-3.55	low_impact	0.09	medium_impact	0.97	medium_impact	0.70	0.85	43.36	8.06	0.36	N	0.29	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14379	14379	C	G	MI.23576	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	295	99	E	Q	Gag/Cag	-0.75	0	0	probably_damaging	1	neutral	0.26	neutral	2.31	neutral	0.03	deleterious	-2.96	medium_impact	2.94	0.88	neutral	0.28	neutral	3.62	23.20	deleterious	0.39	0.5	0.27	neutral	0.29	neutral	0.55	disease	0.47	neutral	1	1	deleterious	0.13	neutral	1	deleterious	0.68	deleterious	-3.55	low_impact	-0.05	medium_impact	1.32	medium_impact	0.81	0.85	43.36	8.06	0.41	N	0.87	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14379	14379	C	T	MI.23577	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	295	99	E	K	Gag/Aag	-0.75	0	0	probably_damaging	1	neutral	0.26	neutral	2.31	neutral	0.27	deleterious	-3.94	medium_impact	3.15	0.78	neutral	0.17	damaging	4.80	24.80	deleterious	0.29	0.45	0.21	neutral	0.58	disease	0.67	disease	0.72	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.70	deleterious	-3.55	low_impact	-0.05	medium_impact	1.5	medium_impact	0.90	0.95	43.36	8.06	0.34	N	0.93	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14380	14380	C	G	MI.23578	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	294	98	M	I	atG/atC	0.4	0	0	probably_damaging	0.99	neutral	0.55	neutral	2.53	neutral	-0.32	neutral	-2.2	medium_impact	2	0.9	neutral	0.91	neutral	2.66	20.60	deleterious	0.57	0.65	0.17	neutral	0.5	disease	0.42	neutral	0.43	neutral	1	0.99	deleterious	0.28	neutral	1	deleterious	0.66	deleterious	-2.63	low_impact	0.26	medium_impact	0.54	medium_impact	0.73	0.85	48.67	8.57	0.3	N	0.89	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14380	14380	C	A	MI.23579	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	294	98	M	I	atG/atT	0.4	0	0	probably_damaging	0.99	neutral	0.55	neutral	2.53	neutral	-0.32	neutral	-2.2	medium_impact	2	0.9	neutral	0.91	neutral	3.02	22.30	deleterious	0.57	0.65	0.17	neutral	0.5	disease	0.42	neutral	0.43	neutral	1	0.99	deleterious	0.28	neutral	1	deleterious	0.66	deleterious	-2.63	low_impact	0.26	medium_impact	0.54	medium_impact	0.73	0.85	48.67	8.57	0.31	N	0.89	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6126	6126	A	C	MI.2358	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	223	75	I	L	Atc/Ctc	-1.26	0	0	probably_damaging	0.97	deleterious	0	neutral	2.91	neutral	-0.56	neutral	-1.17	medium_impact	3.25	0.54	damaging	0.69	neutral	3.69	23.30	deleterious	0.39	0.55	0.26	neutral	0.62	disease	0.37	neutral	0.44	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.65	deleterious	-2.18	low_impact	-1.48	low_impact	1.9	medium_impact	0.77	0.9	10.92	16.76	0.51	N	0.61	disease_causing	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14381	14381	A	G	MI.23580	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	293	98	M	T	aTg/aCg	-9.46	0	0	probably_damaging	0.99	neutral	0.25	neutral	2.3	neutral	-1.29	deleterious	-4.14	medium_impact	2.75	0.86	neutral	0.76	neutral	2.03	16.38	deleterious	0.38	0.5	0.26	neutral	0.48	neutral	0.58	disease	0.56	disease	1	1	deleterious	0.13	neutral	1	deleterious	0.68	deleterious	-2.63	low_impact	-0.06	medium_impact	1.16	medium_impact	0.55	0.8	48.67	8.57	0.4	N	0.87	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14381	14381	A	T	MI.23581	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	293	98	M	K	aTg/aAg	-9.46	0	0	probably_damaging	0.99	neutral	0.25	neutral	2.24	deleterious	-3.75	deleterious	-4.69	medium_impact	3.1	0.78	neutral	0.5	neutral	3.73	23.30	deleterious	0.26	0.45	0.39	neutral	0.76	disease	0.67	disease	0.76	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.74	deleterious	-2.63	low_impact	-0.06	medium_impact	1.46	medium_impact	0.63	0.8	48.67	8.57	0.35	N	0.96	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14382	14382	T	A	MI.23582	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	292	98	M	L	Atg/Ttg	0.86	0	0	probably_damaging	0.98	neutral	0.78	neutral	2.5	neutral	-0.3	neutral	-1.82	low_impact	0.86	0.9	neutral	0.98	neutral	2.43	19.02	deleterious	0.43	0.55	0.11	neutral	0.31	neutral	0.37	neutral	0.44	neutral	1	0.97	neutral	0.4	neutral	-2	neutral	0.63	deleterious	-2.35	low_impact	0.51	medium_impact	-0.42	medium_impact	0.63	0.8	48.67	8.57	0.36	N	0.74	NA	NA	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14382	14382	T	G	MI.23583	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	292	98	M	L	Atg/Ctg	0.86	0	0	probably_damaging	0.98	neutral	0.78	neutral	2.5	neutral	-0.3	neutral	-1.82	low_impact	0.86	0.9	neutral	0.98	neutral	2.30	18.17	deleterious	0.43	0.55	0.11	neutral	0.31	neutral	0.37	neutral	0.44	neutral	1	0.97	neutral	0.4	neutral	-2	neutral	0.63	deleterious	-2.35	low_impact	0.51	medium_impact	-0.42	medium_impact	0.63	0.8	48.67	8.57	0.36	N	0.74	NA	NA	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14382	14382	T	C	MI.23584	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	292	98	M	V	Atg/Gtg	0.86	0	0	probably_damaging	0.99	neutral	1	neutral	2.36	neutral	-0.51	neutral	-2.05	low_impact	1.16	0.92	neutral	0.97	neutral	1.02	10.77	neutral	0.55	0.6	0.13	neutral	0.28	neutral	0.43	neutral	0.43	neutral	1	0.99	deleterious	0.51	deleterious	-2	neutral	0.64	deleterious	-2.63	low_impact	1.87	high_impact	-0.17	medium_impact	0.62	0.8	48.67	8.57	0.34	N	0.85	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14384	14384	G	T	MI.23585	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	290	97	A	E	gCg/gAg	-9.46	0	0	possibly_damaging	0.46	neutral	0.26	neutral	2.16	neutral	-2.54	neutral	-1.88	low_impact	1.83	0.76	neutral	0.6	neutral	2.15	17.16	deleterious	0.15	0.4	0.3	neutral	0.37	neutral	0.66	disease	0.48	neutral	0	0.71	neutral	0.4	neutral	-3	neutral	0.42	neutral	-0.73	medium_impact	-0.05	medium_impact	0.39	medium_impact	0.82	0.85	48.23	8.28	0.46	N	0.42	NA	NA	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14384	14384	G	C	MI.23586	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	290	97	A	G	gCg/gGg	-9.46	0	0	benign	0.33	neutral	0.55	neutral	2.21	neutral	-0.59	neutral	-2.42	neutral_impact	0.13	0.84	neutral	0.72	neutral	0.73	9.00	deleterious	0.19	0.45	0.18	neutral	0.08	neutral	0.32	neutral	0.3	neutral	4	0.36	neutral	0.61	deleterious	-6	neutral	0.35	neutral	-0.51	medium_impact	0.26	medium_impact	-1.03	low_impact	0.72	0.85	48.23	8.28	0.4	N	0.35	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14384	14384	G	A	MI.23587	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	290	97	A	V	gCg/gTg	-9.46	0	0	benign	0	neutral	0.68	neutral	2.29	neutral	0.89	neutral	2.11	neutral_impact	-0.62	0.96	neutral	0.98	neutral	0.06	3.23	deleterious	0.32	0.5	0.09	neutral	0.06	neutral	0.33	neutral	0.24	neutral	5	0.31	neutral	0.84	deleterious	-6	neutral	0.07	neutral	1.95	medium_impact	0.39	medium_impact	-1.66	low_impact	0.79	0.85	48.23	8.28	0.38	N	0.04	NA	NA	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14385	14385	C	G	MI.23588	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	289	97	A	P	Gcg/Ccg	2.23	0	0	possibly_damaging	0.65	neutral	0.19	neutral	2.19	neutral	-2.23	neutral	-2.04	low_impact	1.83	0.73	neutral	0.5	neutral	3.71	23.30	deleterious	0.15	0.4	0.39	neutral	0.47	neutral	0.54	disease	0.54	disease	1	0.83	neutral	0.27	neutral	-3	neutral	0.59	deleterious	-1.04	low_impact	-0.14	medium_impact	0.39	medium_impact	0.79	0.85	48.23	8.28	0.45	N	0.41	NA	NA	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14385	14385	C	A	MI.23589	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	289	97	A	S	Gcg/Tcg	2.23	0	0	benign	0.33	neutral	0.5	neutral	2.2	neutral	-0.83	neutral	-1.02	low_impact	0.94	0.73	neutral	0.79	neutral	2.27	17.99	deleterious	0.29	0.45	0.19	neutral	0.14	neutral	0.42	neutral	0.31	neutral	4	0.41	neutral	0.59	deleterious	-6	neutral	0.31	neutral	-0.51	medium_impact	0.21	medium_impact	-0.35	medium_impact	0.83	0.9	48.23	8.28	0.47	N	0.14	NA	NA	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6126	6126	A	T	MI.2359	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	223	75	I	F	Atc/Ttc	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.91	neutral	-1.23	neutral	-2.5	medium_impact	2.87	0.54	damaging	0.4	neutral	3.66	23.20	deleterious	0.33	0.55	0.28	neutral	0.77	disease	0.39	neutral	0.54	disease	1	1	deleterious	0	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	1.55	medium_impact	0.76	0.9	10.92	16.76	0.38	N	0.85	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14385	14385	C	T	MI.23590	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	289	97	A	T	Gcg/Acg	2.23	0	0	benign	0.2	neutral	0.46	neutral	2.22	neutral	-0.23	neutral	-0.19	low_impact	1.49	0.86	neutral	0.77	neutral	1.48	13.22	neutral	0.3	0.45	0.17	neutral	0.08	neutral	0.45	neutral	0.31	neutral	4	0.45	neutral	0.63	deleterious	-6	neutral	0.23	neutral	-0.24	medium_impact	0.17	medium_impact	0.11	medium_impact	0.77	0.85	48.23	8.28	0.45	N	0.12	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14386	14386	T	A	MI.23591	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	288	96	L	F	ttA/ttT	-10.83	0	0.01	benign	0.09	neutral	0.91	neutral	2.28	neutral	-1.46	deleterious	-2.68	low_impact	1.51	0.89	neutral	0.86	neutral	0.76	9.19	deleterious	0.36	0.5	0.41	neutral	0.46	neutral	0.37	neutral	0.47	neutral	1	0.03	neutral	0.91	deleterious	-6	neutral	0.23	neutral	0.13	medium_impact	0.76	medium_impact	0.13	medium_impact	0.66	0.8	34.51	7.56	0.37	N	0.83	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14386	14386	T	G	MI.23592	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	288	96	L	F	ttA/ttC	-10.83	0	0.01	benign	0.09	neutral	0.91	neutral	2.28	neutral	-1.46	deleterious	-2.68	low_impact	1.51	0.89	neutral	0.86	neutral	0.65	8.50	deleterious	0.36	0.5	0.41	neutral	0.46	neutral	0.37	neutral	0.47	neutral	1	0.03	neutral	0.91	deleterious	-6	neutral	0.23	neutral	0.13	medium_impact	0.76	medium_impact	0.13	medium_impact	0.66	0.8	34.51	7.56	0.32	N	0.83	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14387	14387	A	G	MI.23593	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	287	96	L	S	tTa/tCa	-10.83	0	0	probably_damaging	0.91	neutral	0.52	neutral	2.3	neutral	-0.4	deleterious	-4.58	medium_impact	2.23	0.8	neutral	0.65	neutral	3.80	23.40	deleterious	0.26	0.45	0.57	disease	0.67	disease	0.54	disease	0.7	disease	4	0.9	neutral	0.31	neutral	1	deleterious	0.74	deleterious	-1.72	low_impact	0.23	medium_impact	0.73	medium_impact	0.66	0.8	34.51	7.56	0.25	N	0.91	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14387	14387	A	C	MI.23594	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	287	96	L	W	tTa/tGa	-10.83	0	0	probably_damaging	0.95	neutral	0.18	neutral	2.19	deleterious	-5.48	deleterious	-4.82	medium_impact	3.33	0.78	neutral	0.38	neutral	3.37	22.90	deleterious	0.15	0.4	0.78	disease	0.73	disease	0.57	disease	0.73	disease	5	0.97	neutral	0.12	neutral	1	deleterious	0.78	deleterious	-1.97	low_impact	-0.16	medium_impact	1.65	medium_impact	0.61	0.8	34.51	7.56	0.33	N	0.93	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14388	14388	A	T	MI.23595	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	286	96	L	M	Tta/Ata	2.92	0.02	0	benign	0.33	neutral	0.37	neutral	2.25	neutral	-2.26	neutral	-1.08	low_impact	1.66	0.86	neutral	0.88	neutral	2.12	16.99	deleterious	0.34	0.5	0.45	neutral	0.26	neutral	0.35	neutral	0.45	neutral	1	0.56	neutral	0.52	deleterious	-6	neutral	0.47	deleterious	-0.51	medium_impact	0.08	medium_impact	0.25	medium_impact	0.68	0.85	34.51	7.56	0.43	N	0.58	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14388	14388	A	C	MI.23596	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	286	96	L	V	Tta/Gta	2.92	0.02	0	benign	0.33	neutral	0.68	neutral	2.31	neutral	-1.05	neutral	-1.04	low_impact	1.18	0.87	neutral	0.98	neutral	1.05	10.97	neutral	0.31	0.5	0.25	neutral	0.15	neutral	0.3	neutral	0.27	neutral	5	0.26	neutral	0.68	deleterious	-6	neutral	0.44	deleterious	-0.51	medium_impact	0.39	medium_impact	-0.15	medium_impact	0.68	0.85	34.51	7.56	0.39	N	0.42	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14390	14390	C	A	MI.23597	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	284	95	G	V	gGg/gTg	-12.44	0	0	probably_damaging	1	neutral	0.57	neutral	2.41	neutral	1.35	deleterious	-8.4	low_impact	1.81	0.81	neutral	0.45	neutral	4.31	24.00	deleterious	0.28	0.45	0.62	disease	0.55	disease	0.47	neutral	0.51	disease	0	1	deleterious	0.29	neutral	-2	neutral	0.78	deleterious	-3.55	low_impact	0.27	medium_impact	0.38	medium_impact	0.69	0.85	50.44	8.81	0.29	N	0.80	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14390	14390	C	G	MI.23598	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	284	95	G	A	gGg/gCg	-12.44	0	0	probably_damaging	1	neutral	0.38	neutral	2.43	neutral	0.66	deleterious	-5.45	medium_impact	2.29	0.83	neutral	0.65	neutral	3.27	22.80	deleterious	0.45	0.55	0.49	neutral	0.45	neutral	0.52	disease	0.45	neutral	1	1	deleterious	0.19	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	0.09	medium_impact	0.78	medium_impact	0.77	0.85	50.44	8.81	0.36	N	0.75	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14390	14390	C	T	MI.23599	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	284	95	G	E	gGg/gAg	-12.44	0	0	probably_damaging	1	neutral	0.14	neutral	2.27	neutral	-2.55	deleterious	-7.35	high_impact	3.52	0.81	neutral	0.13	damaging	4.10	23.70	deleterious	0.29	0.45	0.58	disease	0.73	disease	0.72	disease	0.76	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.80	deleterious	-3.55	low_impact	-0.23	medium_impact	1.81	medium_impact	0.77	0.85	50.44	8.81	0.29	N	0.94	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8638	8638	A	T	MI.236	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	112	38	I	F	Atc/Ttc	-0.1	0	0	probably_damaging	0.99	neutral	0.16	neutral	4.25	neutral	-2.15	deleterious	-2.59	low_impact	1.73	0.92	neutral	0.55	neutral	2.56	19.84	deleterious	0.52	0.65	0.62	disease	0.62	disease	0.38	neutral	0.51	disease	0	0.99	deleterious	0.09	neutral	-2	neutral	0.75	deleterious	-2.65	low_impact	-0.12	medium_impact	0.39	medium_impact	0.61	0.9	15.49	18.25	0.4	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6127	6127	T	G	MI.2360	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	224	75	I	S	aTc/aGc	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.83	neutral	-1.52	deleterious	-3.78	high_impact	4.17	0.67	neutral	0.52	neutral	4.21	23.90	deleterious	0.27	0.55	0.46	neutral	0.82	disease	0.61	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.75	high_impact	0.61	0.9	10.92	16.76	0.53	P	0.62	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14391	14391	C	G	MI.23600	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	283	95	G	R	Ggg/Cgg	-0.29	0	0	probably_damaging	1	neutral	0.18	neutral	2.27	neutral	-2.29	deleterious	-7.46	high_impact	3.52	0.78	neutral	0.08	damaging	4.18	23.80	deleterious	0.14	0.4	0.66	disease	0.69	disease	0.72	disease	0.75	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.80	deleterious	-3.55	low_impact	-0.16	medium_impact	1.81	medium_impact	0.77	0.85	50.44	8.81	0.26	N	0.96	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14391	14391	C	A	MI.23601	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	283	95	G	W	Ggg/Tgg	-0.29	0	0	probably_damaging	1	neutral	0.19	neutral	2.26	neutral	-2.28	deleterious	-7.6	medium_impact	3.18	0.79	neutral	0.1	damaging	4.88	24.90	deleterious	0.22	0.45	0.87	disease	0.76	disease	0.66	disease	0.79	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	-0.14	medium_impact	1.52	medium_impact	0.52	0.8	50.44	8.81	0.29	N	0.98	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14393	14393	A	T	MI.23602	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	281	94	V	E	gTg/gAg	-7.85	0	0	benign	0.28	neutral	0.19	neutral	2.19	neutral	-2.96	deleterious	-3.68	medium_impact	2.44	0.77	neutral	0.42	neutral	3.94	23.50	deleterious	0.2	0.45	0.37	neutral	0.69	disease	0.68	disease	0.74	disease	5	0.77	neutral	0.46	neutral	-3	neutral	0.47	deleterious	-0.42	medium_impact	-0.14	medium_impact	0.9	medium_impact	0.71	0.85	49.56	8.53	0.33	N	0.80	NA	NA	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14393	14393	A	C	MI.23603	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	281	94	V	G	gTg/gGg	-7.85	0	0	benign	0.21	neutral	0.28	neutral	2.34	neutral	-2.4	deleterious	-4.27	low_impact	1.88	0.87	neutral	0.74	neutral	0.78	9.36	deleterious	0.26	0.45	0.41	neutral	0.45	neutral	0.44	neutral	0.47	neutral	1	0.66	neutral	0.54	deleterious	-6	neutral	0.34	neutral	-0.27	medium_impact	-0.02	medium_impact	0.44	medium_impact	0.65	0.8	49.56	8.53	0.45	N	0.81	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14393	14393	A	G	MI.23604	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	281	94	V	A	gTg/gCg	-7.85	0	0	benign	0.01	neutral	0.38	neutral	2.32	neutral	-0.87	neutral	-1.91	low_impact	1.74	0.93	neutral	0.92	neutral	0.68	8.69	deleterious	0.36	0.5	0.21	neutral	0.33	neutral	0.5	neutral	0.45	neutral	1	0.61	neutral	0.69	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.09	medium_impact	0.32	medium_impact	0.66	0.8	49.56	8.53	0.38	N	0.43	NA	NA	0.36	rs878853104	Likely_benign	not_provided	237423	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14394	14394	C	T	MI.23605	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	280	94	V	M	Gtg/Atg	0.17	0	0	benign	0.03	neutral	0.24	neutral	2.21	neutral	-1.54	neutral	-0.04	low_impact	0.91	0.92	neutral	0.98	neutral	0.41	6.71	deleterious	0.4	0.5	0.31	neutral	0.19	neutral	0.36	neutral	0.36	neutral	3	0.75	neutral	0.61	deleterious	-6	neutral	0.13	neutral	0.59	medium_impact	-0.07	medium_impact	-0.38	medium_impact	0.77	0.85	49.56	8.53	0.54	P	0.60	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14394	14394	C	A	MI.23606	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	280	94	V	L	Gtg/Ttg	0.17	0	0	benign	0	neutral	0.66	neutral	2.36	neutral	0.67	neutral	0.49	neutral_impact	-0.36	0.93	neutral	0.94	neutral	-0.56	0.15	neutral	0.41	0.5	0.12	neutral	0.16	neutral	0.31	neutral	0.27	neutral	5	0.33	neutral	0.83	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.37	medium_impact	-1.44	low_impact	0.73	0.85	49.56	8.53	0.41	N	0.41	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14394	14394	C	G	MI.23607	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	280	94	V	L	Gtg/Ctg	0.17	0	0	benign	0	neutral	0.66	neutral	2.36	neutral	0.67	neutral	0.49	neutral_impact	-0.36	0.93	neutral	0.94	neutral	-0.82	0.04	neutral	0.41	0.5	0.12	neutral	0.16	neutral	0.31	neutral	0.27	neutral	5	0.33	neutral	0.83	deleterious	-6	neutral	0.10	neutral	1.95	medium_impact	0.37	medium_impact	-1.44	low_impact	0.73	0.85	49.56	8.53	0.38	N	0.41	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14395	14395	T	A	MI.23608	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	279	93	L	F	ttA/ttT	-6.02	0	0	possibly_damaging	0.89	neutral	0.88	neutral	2.29	neutral	-0.63	neutral	-2.29	low_impact	1.46	0.86	neutral	0.97	neutral	2.26	17.89	deleterious	0.41	0.5	0.43	neutral	0.32	neutral	0.38	neutral	0.45	neutral	1	0.88	neutral	0.5	deleterious	-3	neutral	0.66	deleterious	-1.63	low_impact	0.69	medium_impact	0.08	medium_impact	0.64	0.8	46.02	8.31	0.24	N	0.54	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14395	14395	T	G	MI.23609	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	279	93	L	F	ttA/ttC	-6.02	0	0	possibly_damaging	0.89	neutral	0.88	neutral	2.29	neutral	-0.63	neutral	-2.29	low_impact	1.46	0.86	neutral	0.97	neutral	2.02	16.33	deleterious	0.41	0.5	0.43	neutral	0.32	neutral	0.38	neutral	0.45	neutral	1	0.88	neutral	0.5	deleterious	-3	neutral	0.66	deleterious	-1.63	low_impact	0.69	medium_impact	0.08	medium_impact	0.64	0.8	46.02	8.31	0.25	N	0.54	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6127	6127	T	C	MI.2361	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	224	75	I	T	aTc/aCc	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.83	neutral	-1.73	deleterious	-3.16	high_impact	3.88	0.54	damaging	0.5	neutral	3.39	23.00	deleterious	0.44	0.55	0.47	neutral	0.76	disease	0.59	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.48	high_impact	0.65	0.9	10.92	16.76	0.51	P	0.76	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14396	14396	A	C	MI.23610	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	278	93	L	W	tTa/tGa	-3.27	0	0	probably_damaging	0.98	neutral	0.2	neutral	2.17	deleterious	-3.51	deleterious	-4.56	medium_impact	3.07	0.74	neutral	0.38	neutral	3.40	23.00	deleterious	0.14	0.4	0.83	disease	0.6	disease	0.57	disease	0.71	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.77	deleterious	-2.35	low_impact	-0.13	medium_impact	1.43	medium_impact	0.61	0.8	46.02	8.31	0.35	N	0.85	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14396	14396	A	G	MI.23611	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	278	93	L	S	tTa/tCa	-3.27	0	0	probably_damaging	0.92	neutral	0.45	neutral	2.23	neutral	-2.31	deleterious	-4.16	medium_impact	2.17	0.71	neutral	0.67	neutral	3.82	23.40	deleterious	0.27	0.45	0.59	disease	0.57	disease	0.54	disease	0.62	disease	2	0.92	neutral	0.27	neutral	1	deleterious	0.73	deleterious	-1.77	low_impact	0.16	medium_impact	0.68	medium_impact	0.69	0.85	46.02	8.31	0.3	N	0.80	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14397	14397	A	C	MI.23612	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	277	93	L	V	Tta/Gta	-0.5	0	0	benign	0.1	neutral	0.61	neutral	2.34	neutral	-1.04	neutral	-0.09	neutral_impact	0.52	0.94	neutral	0.97	neutral	0.37	6.36	deleterious	0.39	0.5	0.08	neutral	0.16	neutral	0.31	neutral	0.26	neutral	5	0.29	neutral	0.76	deleterious	-6	neutral	0.20	neutral	0.08	medium_impact	0.31	medium_impact	-0.7	medium_impact	0.63	0.8	46.02	8.31	0.4	N	0.14	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14397	14397	A	T	MI.23613	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	277	93	L	M	Tta/Ata	-0.5	0	0	benign	0.33	neutral	0.33	neutral	2.2	neutral	-1.58	neutral	-0.9	low_impact	1.11	0.94	neutral	0.89	neutral	1.79	14.95	neutral	0.29	0.45	0.38	neutral	0.18	neutral	0.35	neutral	0.31	neutral	4	0.6	neutral	0.5	deleterious	-6	neutral	0.41	neutral	-0.51	medium_impact	0.04	medium_impact	-0.21	medium_impact	0.73	0.85	46.02	8.31	0.55	N	0.55	NA	NA	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14399	14399	A	T	MI.23614	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	275	92	V	D	gTt/gAt	-8.3	0	0	possibly_damaging	0.6	neutral	0.17	neutral	2.23	deleterious	-4.26	deleterious	-3.77	medium_impact	2.32	0.71	neutral	0.4	neutral	3.86	23.50	deleterious	0.12	0.4	0.7	disease	0.7	disease	0.76	disease	0.79	disease	6	0.83	neutral	0.29	neutral	0	NA	0.57	deleterious	-0.96	medium_impact	-0.18	medium_impact	0.8	medium_impact	0.75	0.85	50	8.7	0.32	N	0.84	NA	NA	0.65	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14399	14399	A	G	MI.23615	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	275	92	V	A	gTt/gCt	-8.3	0	0	benign	0.15	neutral	0.62	neutral	2.33	neutral	0.36	neutral	-1.71	low_impact	1.12	0.76	neutral	0.76	neutral	1.81	15.03	deleterious	0.33	0.5	0.32	neutral	0.34	neutral	0.49	neutral	0.46	neutral	1	0.27	neutral	0.74	deleterious	-6	neutral	0.22	neutral	-0.11	medium_impact	0.32	medium_impact	-0.2	medium_impact	0.75	0.85	50	8.7	0.39	N	0.52	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14399	14399	A	C	MI.23616	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	275	92	V	G	gTt/gGt	-8.3	0	0	benign	0.31	neutral	0.48	neutral	2.27	neutral	-1.32	deleterious	-3.76	low_impact	0.88	0.83	neutral	0.71	neutral	3.11	22.50	deleterious	0.25	0.45	0.58	disease	0.46	neutral	0.58	disease	0.62	disease	2	0.43	neutral	0.59	deleterious	-6	neutral	0.43	neutral	-0.48	medium_impact	0.19	medium_impact	-0.4	medium_impact	0.79	0.85	50	8.7	0.3	N	0.83	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14400	14400	C	G	MI.23617	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	274	92	V	L	Gtt/Ctt	0.64	0	0	benign	0.01	neutral	1	neutral	2.35	neutral	2.18	neutral	1.42	neutral_impact	-0.7	0.95	neutral	0.89	neutral	-0.92	0.02	neutral	0.4	0.5	0.11	neutral	0.17	neutral	0.34	neutral	0.25	neutral	5	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	1.87	high_impact	-1.73	low_impact	0.79	0.85	50	8.7	0.39	N	0.33	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14400	14400	C	A	MI.23618	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	274	92	V	F	Gtt/Ttt	0.64	0	0	benign	0.01	neutral	0.93	neutral	2.3	neutral	-0.82	neutral	1.91	neutral_impact	-0.48	0.95	neutral	0.9	neutral	0.26	5.27	deleterious	0.26	0.45	0.1	neutral	0.38	neutral	0.4	neutral	0.43	neutral	1	0.04	neutral	0.96	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.83	medium_impact	-1.54	low_impact	0.86	0.9	50	8.7	0.32	N	0.34	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14400	14400	C	T	MI.23619	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	274	92	V	I	Gtt/Att	0.64	0	0	benign	0.14	neutral	0.53	neutral	2.3	neutral	0.3	neutral	0.73	low_impact	1.08	0.81	neutral	0.68	neutral	1.85	15.30	deleterious	0.51	0.6	0.17	neutral	0.18	neutral	0.41	neutral	0.32	neutral	4	0.37	neutral	0.7	deleterious	-6	neutral	0.17	neutral	-0.07	medium_impact	0.24	medium_impact	-0.24	medium_impact	0.84	0.9	50	8.7	0.32	N	0.37	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6127	6127	T	A	MI.2362	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	224	75	I	N	aTc/aAc	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.77	deleterious	-3.53	deleterious	-4.44	high_impact	4.86	0.56	damaging	0.42	neutral	4.44	24.20	deleterious	0.27	0.55	0.7	disease	0.81	disease	0.6	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.66	0.9	10.92	16.76	0.69	P	0.94	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14402	14402	C	A	MI.23620	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	272	91	S	I	aGt/aTt	-10.83	0	0	benign	0.01	neutral	0.84	neutral	2.17	neutral	-0.08	neutral	-1.27	neutral_impact	0.1	0.9	neutral	0.86	neutral	2.62	20.30	deleterious	0.32	0.5	0.13	neutral	0.45	neutral	0.51	disease	0.46	neutral	1	0.13	neutral	0.92	deleterious	-6	neutral	0.13	neutral	1.03	medium_impact	0.61	medium_impact	-1.06	low_impact	0.87	0.9	20.35	20.41	0.31	N	0.55	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14402	14402	C	T	MI.23621	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	272	91	S	N	aGt/aAt	-10.83	0	0	benign	0.18	neutral	0.27	neutral	2.28	neutral	0.67	neutral	-2.15	low_impact	1.56	0.77	neutral	0.65	neutral	1.01	10.69	neutral	0.51	0.6	0.27	neutral	0.26	neutral	0.42	neutral	0.44	neutral	1	0.68	neutral	0.55	deleterious	-6	neutral	0.31	neutral	-0.19	medium_impact	-0.03	medium_impact	0.17	medium_impact	0.75	0.85	20.35	20.41	0.42	N	0.39	NA	NA	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14402	14402	C	G	MI.23622	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	272	91	S	T	aGt/aCt	-10.83	0	0	benign	0.01	neutral	0.39	neutral	2.21	neutral	-0.28	neutral	-0.63	neutral_impact	0.76	0.89	neutral	0.93	neutral	0.22	4.87	deleterious	0.34	0.5	0.16	neutral	0.15	neutral	0.38	neutral	0.33	neutral	3	0.6	neutral	0.69	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.1	medium_impact	-0.5	medium_impact	0.82	0.85	20.35	20.41	0.41	N	0.10	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14403	14403	T	G	MI.23623	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	271	91	S	R	Agt/Cgt	-2.8	0	0	benign	0.3	neutral	0.23	neutral	2.19	neutral	-2.37	neutral	-2.33	low_impact	1.56	0.74	neutral	0.59	neutral	2.73	21.00	deleterious	0.2	0.45	0.25	neutral	0.47	neutral	0.65	disease	0.56	disease	1	0.72	neutral	0.47	neutral	-6	neutral	0.40	neutral	-0.46	medium_impact	-0.09	medium_impact	0.17	medium_impact	0.87	0.9	20.35	20.41	0.39	N	0.60	NA	NA	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14403	14403	T	A	MI.23624	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	271	91	S	C	Agt/Tgt	-2.8	0	0	benign	0.01	neutral	0.17	neutral	2.15	deleterious	-3.38	neutral	-1.64	low_impact	1.56	0.92	neutral	0.67	neutral	0.76	9.21	deleterious	0.25	0.45	0.38	neutral	0.41	neutral	0.4	neutral	0.46	neutral	1	0.83	neutral	0.58	deleterious	-6	neutral	0.16	neutral	1.03	medium_impact	-0.18	medium_impact	0.17	medium_impact	0.81	0.85	20.35	20.41	0.53	N	0.49	NA	NA	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14403	14403	T	C	MI.23625	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	271	91	S	G	Agt/Ggt	-2.8	0	0	benign	0	neutral	0.58	neutral	2.21	neutral	-0.36	neutral	-1.67	neutral_impact	-0.36	0.97	neutral	0.88	neutral	-0.42	0.34	neutral	0.37	0.5	0.28	neutral	0.16	neutral	0.49	neutral	0.31	neutral	4	0.42	neutral	0.79	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.28	medium_impact	-1.44	low_impact	0.82	0.85	20.35	20.41	0.29	N	0.08	NA	NA	0.27	.	.	.	.	.	.	COSM6716809	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14405	14405	A	G	MI.23626	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	269	90	V	A	gTg/gCg	-9.45	0	0	benign	0	neutral	0.4	neutral	2.38	neutral	0.2	neutral	2.56	neutral_impact	0.28	0.95	neutral	0.95	neutral	0.63	8.34	deleterious	0.35	0.5	0.13	neutral	0.32	neutral	0.47	neutral	0.44	neutral	1	0.6	neutral	0.7	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.11	medium_impact	-0.91	medium_impact	0.73	0.85	23.45	16.35	0.31	N	0.14	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14405	14405	A	C	MI.23627	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	269	90	V	G	gTg/gGg	-9.45	0	0	benign	0	neutral	0.39	neutral	2.51	neutral	-1.23	neutral	6.65	neutral_impact	-1.8	0.97	neutral	0.96	neutral	-1.21	0.01	neutral	0.29	0.45	0.14	neutral	0.24	neutral	0.43	neutral	0.42	neutral	2	0.61	neutral	0.7	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	0.1	medium_impact	-2.65	low_impact	0.70	0.85	23.45	16.35	0.32	N	0.22	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14405	14405	A	T	MI.23628	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	269	90	V	E	gTg/gAg	-9.45	0	0	benign	0.09	neutral	0.22	neutral	2.35	deleterious	-3.4	neutral	0.57	low_impact	0.97	0.75	neutral	0.66	neutral	2.41	18.91	deleterious	0.2	0.45	0.22	neutral	0.69	disease	0.64	disease	0.69	disease	4	0.75	neutral	0.57	deleterious	-6	neutral	0.27	neutral	0.13	medium_impact	-0.1	medium_impact	-0.33	medium_impact	0.81	0.85	23.45	16.35	0.39	N	0.59	NA	NA	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14406	14406	C	A	MI.23629	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	268	90	V	L	Gtg/Ttg	-0.5	0	0	benign	0.06	neutral	0.82	neutral	2.33	neutral	0.56	neutral	-0.76	neutral_impact	0.28	0.88	neutral	0.85	neutral	1.14	11.45	neutral	0.44	0.55	0.14	neutral	0.26	neutral	0.32	neutral	0.42	neutral	2	0.09	neutral	0.88	deleterious	-6	neutral	0.14	neutral	0.3	medium_impact	0.57	medium_impact	-0.91	medium_impact	0.82	0.85	23.45	16.35	0.27	N	0.59	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6128	6128	C	G	MI.2363	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	225	75	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0.04	neutral	2.82	neutral	-2.14	neutral	-1.65	low_impact	1.82	0.64	neutral	0.56	neutral	2.14	17.14	deleterious	0.44	0.55	0.52	disease	0.52	disease	0.32	neutral	0.46	neutral	1	1	deleterious	0.02	neutral	2	deleterious	0.72	deleterious	-3.58	low_impact	-0.58	medium_impact	0.58	medium_impact	0.83	0.9	10.92	16.76	0.51	P	0.76	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14406	14406	C	T	MI.23630	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	268	90	V	M	Gtg/Atg	-0.5	0	0	possibly_damaging	0.62	neutral	0.33	neutral	2.27	neutral	-1.47	neutral	0.1	neutral_impact	0.77	0.85	neutral	0.75	neutral	3.64	23.20	deleterious	0.41	0.5	0.26	neutral	0.2	neutral	0.36	neutral	0.38	neutral	2	0.7	neutral	0.36	neutral	-3	neutral	0.48	deleterious	-0.99	medium_impact	0.04	medium_impact	-0.5	medium_impact	0.83	0.85	23.45	16.35	0.42	N	0.55	NA	NA	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14406	14406	C	G	MI.23631	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	268	90	V	L	Gtg/Ctg	-0.5	0	0	benign	0.06	neutral	0.82	neutral	2.33	neutral	0.56	neutral	-0.76	neutral_impact	0.28	0.88	neutral	0.85	neutral	0.79	9.40	deleterious	0.44	0.55	0.14	neutral	0.26	neutral	0.32	neutral	0.42	neutral	2	0.09	neutral	0.88	deleterious	-6	neutral	0.14	neutral	0.3	medium_impact	0.57	medium_impact	-0.91	medium_impact	0.82	0.85	23.45	16.35	0.3	N	0.59	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14407	14407	C	A	MI.23632	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	267	89	L	F	ttG/ttT	-0.96	0	0	benign	0.1	neutral	0.86	neutral	2.14	neutral	-0.33	neutral	-0.79	low_impact	1.65	0.93	neutral	0.95	neutral	0.80	9.46	deleterious	0.41	0.5	0.18	neutral	0.32	neutral	0.35	neutral	0.44	neutral	1	0.05	neutral	0.88	deleterious	-6	neutral	0.16	neutral	0.08	medium_impact	0.64	medium_impact	0.24	medium_impact	0.64	0.8	49.12	8.71	0.35	N	0.32	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14407	14407	C	G	MI.23633	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	267	89	L	F	ttG/ttC	-0.96	0	0	benign	0.1	neutral	0.86	neutral	2.14	neutral	-0.33	neutral	-0.79	low_impact	1.65	0.93	neutral	0.95	neutral	0.32	5.87	deleterious	0.41	0.5	0.18	neutral	0.32	neutral	0.35	neutral	0.44	neutral	1	0.05	neutral	0.88	deleterious	-6	neutral	0.16	neutral	0.08	medium_impact	0.64	medium_impact	0.24	medium_impact	0.64	0.8	49.12	8.71	0.35	N	0.32	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14408	14408	A	C	MI.23634	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	266	89	L	W	tTg/tGg	-7.16	0	0	probably_damaging	0.98	neutral	0.18	neutral	2.05	neutral	-2.27	neutral	0.41	low_impact	1.52	0.88	neutral	0.91	neutral	1.92	15.69	deleterious	0.17	0.45	0.38	neutral	0.59	disease	0.4	neutral	0.49	neutral	0	0.99	deleterious	0.1	neutral	-2	neutral	0.70	deleterious	-2.35	low_impact	-0.16	medium_impact	0.13	medium_impact	0.63	0.8	49.12	8.71	0.42	N	0.57	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14408	14408	A	G	MI.23635	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	266	89	L	S	tTg/tCg	-7.16	0	0	probably_damaging	0.96	neutral	0.51	neutral	2.09	neutral	-1.62	deleterious	-3.82	medium_impact	2.21	0.84	neutral	0.76	neutral	3.74	23.30	deleterious	0.27	0.45	0.55	disease	0.6	disease	0.54	disease	0.6	disease	2	0.95	neutral	0.28	neutral	1	deleterious	0.74	deleterious	-2.06	low_impact	0.22	medium_impact	0.71	medium_impact	0.82	0.85	49.12	8.71	0.26	N	0.85	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14409	14409	A	C	MI.23636	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	265	89	L	V	Ttg/Gtg	0.41	0	0	possibly_damaging	0.69	neutral	0.89	neutral	2.24	neutral	-0.09	neutral	-1.96	low_impact	1.82	0.85	neutral	0.88	neutral	0.13	3.93	deleterious	0.41	0.5	0.31	neutral	0.19	neutral	0.31	neutral	0.36	neutral	3	0.64	neutral	0.6	deleterious	-3	neutral	0.56	deleterious	-1.11	low_impact	0.71	medium_impact	0.39	medium_impact	0.77	0.85	49.12	8.71	0.29	N	0.53	NA	NA	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14409	14409	A	T	MI.23637	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	265	89	L	M	Ttg/Atg	0.41	0	0	probably_damaging	0.96	neutral	0.38	neutral	2.13	neutral	-1.45	neutral	-0.41	low_impact	1.92	0.91	neutral	0.96	neutral	0.42	6.81	deleterious	0.34	0.5	0.33	neutral	0.18	neutral	0.32	neutral	0.3	neutral	4	0.96	neutral	0.21	neutral	-2	neutral	0.65	deleterious	-2.06	low_impact	0.09	medium_impact	0.47	medium_impact	0.72	0.85	49.12	8.71	0.47	N	0.63	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14411	14411	A	C	MI.23638	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	263	88	V	G	gTc/gGc	-8.76	0	0	probably_damaging	0.97	neutral	0.33	neutral	1.95	deleterious	-3.32	deleterious	-6.8	medium_impact	2.02	0.76	neutral	0.75	neutral	3.34	22.90	deleterious	0.26	0.45	0.75	disease	0.66	disease	0.75	disease	0.67	disease	3	0.98	neutral	0.18	neutral	1	deleterious	0.78	deleterious	-2.18	low_impact	0.04	medium_impact	0.55	medium_impact	0.75	0.85	15.49	18.89	0.31	N	0.90	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14411	14411	A	G	MI.23639	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	263	88	V	A	gTc/gCc	-8.76	0	0	possibly_damaging	0.8	neutral	0.52	neutral	2.03	neutral	-1	deleterious	-3.86	low_impact	1.56	0.88	neutral	0.93	neutral	2.25	17.87	deleterious	0.32	0.5	0.46	neutral	0.44	neutral	0.6	disease	0.49	neutral	0	0.77	neutral	0.36	neutral	-3	neutral	0.67	deleterious	-1.35	low_impact	0.23	medium_impact	0.17	medium_impact	0.81	0.85	15.49	18.89	0.35	N	0.46	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6128	6128	C	A	MI.2364	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	225	75	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0.04	neutral	2.82	neutral	-2.14	neutral	-1.65	low_impact	1.82	0.64	neutral	0.56	neutral	2.64	20.40	deleterious	0.44	0.55	0.52	disease	0.52	disease	0.32	neutral	0.46	neutral	1	1	deleterious	0.02	neutral	2	deleterious	0.72	deleterious	-3.58	low_impact	-0.58	medium_impact	0.58	medium_impact	0.83	0.9	10.92	16.76	0.51	P	0.76	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14411	14411	A	T	MI.23640	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	263	88	V	D	gTc/gAc	-8.76	0	0	probably_damaging	0.98	neutral	0.15	neutral	1.93	deleterious	-4.66	deleterious	-6.55	medium_impact	3.34	0.67	neutral	0.47	neutral	3.94	23.60	deleterious	0.1	0.4	0.83	disease	0.83	disease	0.82	disease	0.86	disease	7	0.99	deleterious	0.09	neutral	1	deleterious	0.84	deleterious	-2.35	low_impact	-0.21	medium_impact	1.66	medium_impact	0.80	0.85	15.49	18.89	0.4	N	0.92	NA	NA	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14412	14412	C	G	MI.23641	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	262	88	V	L	Gtc/Ctc	0.64	0	0	possibly_damaging	0.54	neutral	1	neutral	2.1	neutral	-0.13	neutral	-2.37	low_impact	1.36	0.85	neutral	0.7	neutral	3.38	22.90	deleterious	0.47	0.55	0.24	neutral	0.42	neutral	0.54	disease	0.48	neutral	1	0.54	neutral	0.73	deleterious	-3	neutral	0.52	deleterious	-0.86	medium_impact	1.87	high_impact	0	medium_impact	0.87	0.9	15.49	18.89	0.25	N	0.63	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14412	14412	C	T	MI.23642	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	262	88	V	I	Gtc/Atc	0.64	0	0	benign	0.15	neutral	0.66	neutral	2.06	neutral	0.08	neutral	-0.49	low_impact	0.92	0.93	neutral	0.93	neutral	0.46	7.14	deleterious	0.55	0.6	0.16	neutral	0.28	neutral	0.53	disease	0.46	neutral	1	0.22	neutral	0.76	deleterious	-6	neutral	0.22	neutral	-0.11	medium_impact	0.37	medium_impact	-0.37	medium_impact	0.93	0.95	15.49	18.89	0.32	N	0.12	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14412	14412	C	A	MI.23643	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	262	88	V	F	Gtc/Ttc	0.64	0	0	probably_damaging	0.96	neutral	0.77	neutral	1.98	neutral	-0.41	deleterious	-4.34	low_impact	1.84	0.79	neutral	0.65	neutral	4.23	23.90	deleterious	0.25	0.45	0.34	neutral	0.72	disease	0.74	disease	0.64	disease	3	0.95	neutral	0.41	neutral	-2	neutral	0.71	deleterious	-2.06	low_impact	0.5	medium_impact	0.4	medium_impact	0.90	0.95	15.49	18.89	0.25	N	0.89	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14413	14413	C	G	MI.23644	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	261	87	E	D	gaG/gaC	-1.19	0	0	benign	0.03	neutral	0.17	neutral	2.25	neutral	-0.84	neutral	-0.65	neutral_impact	0.28	0.8	neutral	0.74	neutral	2.36	18.58	deleterious	0.44	0.55	0.25	neutral	0.29	neutral	0.54	disease	0.45	neutral	1	0.82	neutral	0.57	deleterious	-6	neutral	0.12	neutral	0.59	medium_impact	-0.18	medium_impact	-0.91	medium_impact	0.93	0.95	14.6	18.39	0.37	N	0.60	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14413	14413	C	A	MI.23645	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	261	87	E	D	gaG/gaT	-1.19	0	0	benign	0.03	neutral	0.17	neutral	2.25	neutral	-0.84	neutral	-0.65	neutral_impact	0.28	0.8	neutral	0.74	neutral	2.76	21.20	deleterious	0.44	0.55	0.25	neutral	0.29	neutral	0.54	disease	0.45	neutral	1	0.82	neutral	0.57	deleterious	-6	neutral	0.12	neutral	0.59	medium_impact	-0.18	medium_impact	-0.91	medium_impact	0.93	0.95	14.6	18.39	0.38	N	0.60	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14414	14414	T	G	MI.23646	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	260	87	E	A	gAg/gCg	-3.94	0	0	benign	0.37	neutral	0.37	neutral	2.3	neutral	1.97	neutral	1.8	neutral_impact	0.62	0.91	neutral	0.98	neutral	2.24	17.79	deleterious	0.33	0.5	0.1	neutral	0.26	neutral	0.51	disease	0.43	neutral	1	0.56	neutral	0.5	deleterious	-6	neutral	0.36	neutral	-0.58	medium_impact	0.08	medium_impact	-0.62	medium_impact	0.80	0.85	14.6	18.39	0.37	N	0.17	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14414	14414	T	A	MI.23647	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	260	87	E	V	gAg/gTg	-3.94	0	0	benign	0.08	neutral	1	neutral	2.34	neutral	1.86	neutral	3.55	neutral_impact	-1.12	0.9	neutral	0.98	neutral	1.76	14.75	neutral	0.35	0.5	0.09	neutral	0.14	neutral	0.48	neutral	0.26	neutral	5	0.07	neutral	0.96	deleterious	-6	neutral	0.12	neutral	0.18	medium_impact	1.87	high_impact	-2.08	low_impact	0.77	0.85	14.6	18.39	0.37	N	0.56	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14414	14414	T	C	MI.23648	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	260	87	E	G	gAg/gGg	-3.94	0	0	benign	0.03	neutral	0.32	neutral	2.24	neutral	0.98	neutral	-0.82	low_impact	1.18	0.79	neutral	0.75	neutral	1.13	11.39	neutral	0.42	0.55	0.28	neutral	0.24	neutral	0.55	disease	0.45	neutral	1	0.66	neutral	0.65	deleterious	-6	neutral	0.12	neutral	0.59	medium_impact	0.03	medium_impact	-0.15	medium_impact	0.80	0.85	14.6	18.39	0.36	N	0.57	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14415	14415	C	G	MI.23649	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	259	87	E	Q	Gag/Cag	-0.73	0	0	possibly_damaging	0.82	neutral	0.17	neutral	2.26	neutral	-0.28	neutral	-0.05	low_impact	1.87	0.75	neutral	0.65	neutral	1.63	14.02	neutral	0.53	0.6	0.21	neutral	0.19	neutral	0.48	neutral	0.37	neutral	3	0.91	neutral	0.18	neutral	-3	neutral	0.55	deleterious	-1.4	low_impact	-0.18	medium_impact	0.43	medium_impact	0.93	0.95	14.6	18.39	0.51	P	0.54	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6129	6129	G	C	MI.2365	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	226	76	G	R	Gga/Cga	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	1.86	deleterious	-5.82	deleterious	-5.32	high_impact	5.12	0.51	damaging	0.12	damaging	3.78	23.40	deleterious	0.13	0.55	0.63	disease	0.94	disease	0.79	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.79	0.9	1.95	6.7	0.63	P	0.95	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14415	14415	C	T	MI.23650	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	259	87	E	K	Gag/Aag	-0.73	0	0	possibly_damaging	0.65	neutral	0.42	neutral	2.31	neutral	1.84	neutral	-0.13	low_impact	1.87	0.84	neutral	0.74	neutral	4.26	23.90	deleterious	0.36	0.5	0.16	neutral	0.39	neutral	0.6	disease	0.47	neutral	1	0.67	neutral	0.39	neutral	-3	neutral	0.52	deleterious	-1.04	low_impact	0.13	medium_impact	0.43	medium_impact	0.87	0.9	14.6	18.39	0.36	N	0.60	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14417	14417	A	C	MI.23651	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	257	86	V	G	gTt/gGt	-9.68	0	0	benign	0.14	neutral	0.33	neutral	2.23	neutral	0.6	deleterious	-3.83	low_impact	1.46	0.78	neutral	0.8	neutral	0.50	7.43	deleterious	0.28	0.45	0.29	neutral	0.49	neutral	0.49	neutral	0.47	neutral	1	0.61	neutral	0.6	deleterious	-6	neutral	0.24	neutral	-0.07	medium_impact	0.04	medium_impact	0.08	medium_impact	0.67	0.85	50.44	8.61	0.39	N	0.62	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14417	14417	A	T	MI.23652	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	257	86	V	D	gTt/gAt	-9.68	0	0	benign	0.35	neutral	0.21	neutral	2.22	neutral	0.1	deleterious	-3.97	medium_impact	1.98	0.76	neutral	0.7	neutral	1.49	13.26	neutral	0.21	0.45	0.24	neutral	0.71	disease	0.56	disease	0.71	disease	4	0.75	neutral	0.43	neutral	-3	neutral	0.46	deleterious	-0.55	medium_impact	-0.11	medium_impact	0.52	medium_impact	0.66	0.8	50.44	8.61	0.38	N	0.65	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14417	14417	A	G	MI.23653	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	257	86	V	A	gTt/gCt	-9.68	0	0	benign	0	neutral	0.51	neutral	2.28	neutral	0.8	neutral	-1.61	low_impact	1.46	0.93	neutral	0.89	neutral	0.31	5.79	deleterious	0.48	0.55	0.16	neutral	0.32	neutral	0.43	neutral	0.44	neutral	1	0.48	neutral	0.76	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.22	medium_impact	0.08	medium_impact	0.77	0.85	50.44	8.61	0.31	N	0.32	NA	NA	0.27	rs878905427	.	.	.	.	papillary thyroid carcinoma	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14418	14418	C	A	MI.23654	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	256	86	V	F	Gtt/Ttt	-0.73	0	0	benign	0	neutral	0.71	neutral	2.22	neutral	0.23	neutral	-2.17	low_impact	1.08	0.92	neutral	0.78	neutral	0.21	4.73	deleterious	0.27	0.45	0.36	neutral	0.55	disease	0.27	neutral	0.44	neutral	1	0.28	neutral	0.86	deleterious	-6	neutral	0.14	neutral	1.95	medium_impact	0.42	medium_impact	-0.24	medium_impact	0.71	0.85	50.44	8.61	0.3	N	0.18	NA	NA	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14418	14418	C	T	MI.23655	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	256	86	V	I	Gtt/Att	-0.73	0	0	benign	0.01	neutral	0.4	neutral	2.26	neutral	-0.42	neutral	-0.47	low_impact	1.63	0.84	neutral	0.88	neutral	0.25	5.22	deleterious	0.6	0.65	0.24	neutral	0.18	neutral	0.43	neutral	0.33	neutral	3	0.59	neutral	0.7	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	0.11	medium_impact	0.23	medium_impact	0.75	0.85	50.44	8.61	0.42	N	0.07	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14418	14418	C	G	MI.23656	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	256	86	V	L	Gtt/Ctt	-0.73	0	0	benign	0	neutral	0.66	neutral	2.3	neutral	0.91	neutral	-0.76	low_impact	1.19	0.92	neutral	0.86	neutral	-0.29	0.68	neutral	0.48	0.55	0.19	neutral	0.28	neutral	0.24	neutral	0.44	neutral	1	0.33	neutral	0.83	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	0.37	medium_impact	-0.14	medium_impact	0.77	0.85	50.44	8.61	0.36	N	0.39	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14420	14420	C	T	MI.23657	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	254	85	G	E	gGg/gAg	-0.04	0	0	possibly_damaging	0.89	neutral	0.3	neutral	2.37	neutral	0.2	neutral	-0.16	low_impact	1.7	0.7	neutral	0.7	neutral	2.30	18.18	deleterious	0.36	0.5	0.13	neutral	0.65	disease	0.67	disease	0.68	disease	4	0.91	neutral	0.21	neutral	-3	neutral	0.66	deleterious	-1.63	low_impact	0	medium_impact	0.28	medium_impact	0.71	0.85	49.56	8.74	0.38	N	0.69	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14420	14420	C	A	MI.23658	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	254	85	G	V	gGg/gTg	-0.04	0	0	probably_damaging	0.96	neutral	0.51	neutral	2.32	neutral	-0.6	deleterious	-2.87	low_impact	1.27	0.73	neutral	0.74	neutral	4.18	23.80	deleterious	0.29	0.45	0.21	neutral	0.53	disease	0.6	disease	0.49	neutral	0	0.96	neutral	0.28	neutral	-2	neutral	0.66	deleterious	-2.06	low_impact	0.22	medium_impact	-0.08	medium_impact	0.55	0.8	49.56	8.74	0.29	N	0.85	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14420	14420	C	G	MI.23659	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	254	85	G	A	gGg/gCg	-0.04	0	0	possibly_damaging	0.67	neutral	0.52	neutral	2.35	neutral	0.08	neutral	-1.23	low_impact	1.45	0.75	neutral	0.81	neutral	3.20	22.70	deleterious	0.4	0.5	0.15	neutral	0.42	neutral	0.54	disease	0.48	neutral	0	0.64	neutral	0.43	neutral	-3	neutral	0.55	deleterious	-1.08	low_impact	0.23	medium_impact	0.08	medium_impact	0.77	0.85	49.56	8.74	0.34	N	0.65	NA	NA	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6129	6129	G	T	MI.2366	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	226	76	G	W	Gga/Tga	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	1.84	deleterious	-7.99	deleterious	-5.32	high_impact	5.12	0.52	damaging	0.15	damaging	4.26	23.90	deleterious	0.13	0.55	0.86	disease	0.91	disease	0.75	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.46	0.9	1.95	6.7	0.56	P	0.83	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14421	14421	C	G	MI.23660	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	253	85	G	R	Ggg/Cgg	-0.5	0	0	probably_damaging	0.96	neutral	0.36	neutral	2.35	neutral	-0.01	neutral	-0.58	neutral_impact	0.53	0.74	neutral	0.74	neutral	4.10	23.70	deleterious	0.31	0.45	0.12	neutral	0.45	neutral	0.66	disease	0.48	neutral	0	0.96	neutral	0.2	neutral	-2	neutral	0.65	deleterious	-2.06	low_impact	0.07	medium_impact	-0.7	medium_impact	0.89	0.9	49.56	8.74	0.35	N	0.66	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14421	14421	C	A	MI.23661	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	253	85	G	W	Ggg/Tgg	-0.5	0	0	probably_damaging	0.99	neutral	0.19	neutral	2.28	neutral	-0.31	deleterious	-3.5	neutral_impact	0.18	0.68	neutral	0.76	neutral	4.78	24.70	deleterious	0.24	0.45	0.11	neutral	0.4	neutral	0.66	disease	0.48	neutral	0	1	deleterious	0.1	neutral	-2	neutral	0.65	deleterious	-2.63	low_impact	-0.14	medium_impact	-0.99	medium_impact	0.59	0.8	49.56	8.74	0.36	N	0.83	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14423	14423	G	A	MI.23662	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	251	84	S	L	tCa/tTa	-2.57	0	0	probably_damaging	1	neutral	0.74	neutral	2.2	neutral	-2.2	deleterious	-5.94	high_impact	3.69	0.84	neutral	0.15	damaging	4.31	24.00	deleterious	0.54	0.6	0.57	disease	0.82	disease	0.57	disease	0.72	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.80	deleterious	-3.55	low_impact	0.46	medium_impact	1.95	medium_impact	0.93	0.95	42.04	7.65	0.21	N	0.95	NA	NA	0.55	.	.	.	.	.	.	COSM1138264	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14423	14423	G	C	MI.23663	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	251	84	S	W	tCa/tGa	-2.57	0	0	probably_damaging	1	neutral	0.19	neutral	2.17	deleterious	-4.25	deleterious	-6.92	high_impact	3.69	0.79	neutral	0.11	damaging	4.08	23.70	deleterious	0.26	0.45	0.9	disease	0.9	disease	0.65	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.14	medium_impact	1.95	medium_impact	0.58	0.8	42.04	7.65	0.31	N	0.98	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14424	14424	A	G	MI.23664	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	250	84	S	P	Tca/Cca	1.79	0.06	0	probably_damaging	1	neutral	0.27	neutral	2.36	neutral	0.35	deleterious	-4.99	high_impact	3.69	0.75	neutral	0.09	damaging	4.11	23.70	deleterious	0.38	0.5	0.59	disease	0.89	disease	0.58	disease	0.75	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	-0.03	medium_impact	1.95	medium_impact	0.72	0.85	42.04	7.65	0.34	N	0.92	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14424	14424	A	T	MI.23665	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	250	84	S	T	Tca/Aca	1.79	0.06	0	probably_damaging	1	neutral	0.53	neutral	2.23	neutral	-1.21	deleterious	-2.99	medium_impact	2.59	0.86	neutral	0.34	neutral	3.35	22.90	deleterious	0.38	0.5	0.42	neutral	0.62	disease	0.48	neutral	0.49	neutral	0	1	deleterious	0.27	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	0.24	medium_impact	1.03	medium_impact	0.72	0.85	42.04	7.65	0.24	N	0.62	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14424	14424	A	C	MI.23666	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	250	84	S	A	Tca/Gca	1.79	0.06	0	probably_damaging	1	neutral	0.68	neutral	2.23	neutral	-1.2	deleterious	-2.99	medium_impact	2.71	0.79	neutral	0.27	damaging	3.33	22.90	deleterious	0.47	0.55	0.34	neutral	0.65	disease	0.45	neutral	0.5	disease	0	1	deleterious	0.34	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	0.39	medium_impact	1.13	medium_impact	0.78	0.85	42.04	7.65	0.23	N	0.48	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14426	14426	C	A	MI.23667	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	248	83	G	V	gGg/gTg	-9.68	0	0	benign	0.04	neutral	0.52	neutral	2.25	neutral	-1.22	neutral	-0.88	neutral_impact	0.6	0.88	neutral	0.94	neutral	0.00	2.62	deleterious	0.32	0.5	0.19	neutral	0.73	disease	0.47	neutral	0.55	disease	1	0.44	neutral	0.74	deleterious	-6	neutral	0.19	neutral	0.47	medium_impact	0.23	medium_impact	-0.64	medium_impact	0.70	0.85	49.12	8.61	0.29	N	0.30	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14426	14426	C	G	MI.23668	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	248	83	G	A	gGg/gCg	-9.68	0	0	possibly_damaging	0.46	neutral	0.54	neutral	2.29	neutral	-0.52	neutral	-1.07	medium_impact	2.36	0.85	neutral	0.88	neutral	0.39	6.56	deleterious	0.51	0.6	0.26	neutral	0.72	disease	0.54	disease	0.55	disease	1	0.44	neutral	0.54	deleterious	0	NA	0.49	deleterious	-0.73	medium_impact	0.25	medium_impact	0.84	medium_impact	0.78	0.85	49.12	8.61	0.27	N	0.30	NA	NA	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14426	14426	C	T	MI.23669	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	248	83	G	E	gGg/gAg	-9.68	0	0	probably_damaging	0.91	neutral	0.31	neutral	2.31	neutral	-0.09	deleterious	-3.15	medium_impact	2.7	0.62	neutral	0.42	neutral	2.84	21.60	deleterious	0.35	0.5	0.4	neutral	0.86	disease	0.67	disease	0.71	disease	4	0.92	neutral	0.2	neutral	1	deleterious	0.77	deleterious	-1.72	low_impact	0.01	medium_impact	1.12	medium_impact	0.77	0.85	49.12	8.61	0.34	N	0.90	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6130	6130	G	T	MI.2367	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	227	76	G	V	gGa/gTa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	1.85	deleterious	-6.37	deleterious	-5.99	high_impact	5.12	0.49	damaging	0.16	damaging	3.69	23.30	deleterious	0.12	0.55	0.32	neutral	0.93	disease	0.71	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.68	0.9	1.95	6.7	0.56	P	0.93	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14427	14427	C	A	MI.23670	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	247	83	G	W	Ggg/Tgg	-0.96	0	0	probably_damaging	0.97	neutral	0.21	neutral	2.24	neutral	-1.71	deleterious	-3.73	medium_impact	2.82	0.62	neutral	0.42	neutral	4.80	24.80	deleterious	0.28	0.45	0.8	disease	0.89	disease	0.7	disease	0.78	disease	6	0.98	neutral	0.12	neutral	1	deleterious	0.83	deleterious	-2.18	low_impact	-0.11	medium_impact	1.22	medium_impact	0.57	0.8	49.12	8.61	0.29	N	0.82	NA	NA	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14427	14427	C	G	MI.23671	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	247	83	G	R	Ggg/Cgg	-0.96	0	0	probably_damaging	0.93	neutral	0.36	neutral	2.32	neutral	-0.06	deleterious	-3.58	medium_impact	2.96	0.6	damaging	0.36	neutral	2.99	22.20	deleterious	0.33	0.5	0.45	neutral	0.81	disease	0.67	disease	0.68	disease	4	0.94	neutral	0.22	neutral	1	deleterious	0.78	deleterious	-1.83	low_impact	0.07	medium_impact	1.34	medium_impact	0.97	1	49.12	8.61	0.33	N	0.89	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14428	14428	C	A	MI.23672	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	246	82	W	C	tgG/tgT	-0.73	0	0	probably_damaging	1	neutral	0.16	neutral	2.3	deleterious	-5.28	deleterious	-12.79	high_impact	3.94	0.63	neutral	0.05	damaging	4.65	24.50	deleterious	0.32	0.5	0.87	disease	0.93	disease	0.81	disease	0.89	disease	8	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.19	medium_impact	2.16	high_impact	0.28	0.8	15.49	18.3	0.45	N	0.96	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14428	14428	C	G	MI.23673	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	246	82	W	C	tgG/tgC	-0.73	0	0	probably_damaging	1	neutral	0.16	neutral	2.3	deleterious	-5.28	deleterious	-12.79	high_impact	3.94	0.63	neutral	0.05	damaging	4.31	24.00	deleterious	0.32	0.5	0.87	disease	0.93	disease	0.81	disease	0.89	disease	8	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.19	medium_impact	2.16	high_impact	0.28	0.8	15.49	18.3	0.45	N	0.96	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14429	14429	C	G	MI.23674	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	245	82	W	S	tGg/tCg	-3.94	0	0	probably_damaging	1	neutral	0.42	neutral	2.4	deleterious	-3.12	deleterious	-13.79	high_impact	3.6	0.63	neutral	0.08	damaging	4.26	23.90	deleterious	0.33	0.5	0.67	disease	0.95	disease	0.79	disease	0.9	disease	8	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0.13	medium_impact	1.88	medium_impact	0.31	0.8	15.49	18.3	0.43	N	0.92	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14429	14429	C	A	MI.23675	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	245	82	W	L	tGg/tTg	-3.94	0	0	probably_damaging	1	neutral	0.72	neutral	2.38	neutral	-2.26	deleterious	-12.73	medium_impact	2.47	0.83	neutral	0.41	neutral	4.71	24.60	deleterious	0.26	0.45	0.62	disease	0.84	disease	0.68	disease	0.56	disease	1	1	deleterious	0.36	neutral	1	deleterious	0.84	deleterious	-3.55	low_impact	0.43	medium_impact	0.93	medium_impact	0.28	0.8	15.49	18.3	0.28	N	0.95	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14430	14430	A	C	MI.23676	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	244	82	W	G	Tgg/Ggg	0.64	0.06	0	probably_damaging	1	neutral	0.35	neutral	2.36	deleterious	-4.06	deleterious	-12.83	medium_impact	3.4	0.64	neutral	0.09	damaging	3.77	23.40	deleterious	0.35	0.5	0.72	disease	0.91	disease	0.8	disease	0.85	disease	7	1	deleterious	0.18	neutral	1	deleterious	0.85	deleterious	-3.55	low_impact	0.06	medium_impact	1.71	medium_impact	0.25	0.8	15.49	18.3	0.46	N	0.90	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14430	14430	A	G	MI.23677	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	244	82	W	R	Tgg/Cgg	0.64	0.06	0	probably_damaging	1	neutral	0.34	neutral	2.38	deleterious	-3.33	deleterious	-13.79	high_impact	3.94	0.61	neutral	0.06	damaging	3.79	23.40	deleterious	0.43	0.55	0.73	disease	0.93	disease	0.79	disease	0.84	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.05	medium_impact	2.16	high_impact	0.25	0.8	15.49	18.3	0.54	P	0.96	NA	NA	0.76	.	.	.	.	.	.	.	.	.	A14430G	Thyroid Cancer	+	-	Reported	1	.	P	P	damaging
chrM	14432	14432	G	T	MI.23678	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	242	81	A	E	gCa/gAa	-3.49	0	0	possibly_damaging	0.77	neutral	0.49	neutral	2.34	neutral	0.38	neutral	-2.49	medium_impact	2.77	0.75	neutral	0.45	neutral	3.59	23.20	deleterious	0.35	0.5	0.48	neutral	0.8	disease	0.57	disease	0.76	disease	5	0.75	neutral	0.36	neutral	0	NA	0.70	deleterious	-1.28	low_impact	0.2	medium_impact	1.18	medium_impact	0.86	0.9	26.99	25.17	0.26	N	0.75	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14432	14432	G	C	MI.23679	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	242	81	A	G	gCa/gGa	-3.49	0	0	possibly_damaging	0.46	neutral	0.46	neutral	2.28	neutral	-1.23	deleterious	-2.79	low_impact	1.62	0.78	neutral	0.7	neutral	2.12	16.96	deleterious	0.31	0.45	0.5	neutral	0.43	neutral	0.27	neutral	0.32	neutral	4	0.51	neutral	0.5	deleterious	-3	neutral	0.55	deleterious	-0.73	medium_impact	0.17	medium_impact	0.22	medium_impact	0.85	0.9	26.99	25.17	0.3	N	0.51	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6130	6130	G	C	MI.2368	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	227	76	G	A	gGa/gCa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	1.95	deleterious	-3.86	deleterious	-3.99	high_impact	3.81	0.66	neutral	0.3	neutral	3.00	22.20	deleterious	0.22	0.55	0.31	neutral	0.81	disease	0.61	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.42	high_impact	0.68	0.9	1.95	6.7	0.46	N	0.64	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14432	14432	G	A	MI.23680	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	242	81	A	V	gCa/gTa	-3.49	0	0	possibly_damaging	0.58	neutral	0.57	neutral	2.33	neutral	0.23	neutral	-0.28	low_impact	1.29	0.86	neutral	0.9	neutral	0.34	6.10	deleterious	0.44	0.55	0.17	neutral	0.53	disease	0.32	neutral	0.46	neutral	1	0.53	neutral	0.5	deleterious	-3	neutral	0.50	deleterious	-0.92	medium_impact	0.27	medium_impact	-0.06	medium_impact	0.85	0.9	26.99	25.17	0.25	N	0.12	NA	NA	0.20	.	.	.	.	.	.	COSM5654576	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14433	14433	C	G	MI.23681	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	241	81	A	P	Gca/Cca	-0.04	0	0	probably_damaging	0.91	neutral	0.26	neutral	2.28	neutral	-1.41	deleterious	-2.59	medium_impact	2.77	0.78	neutral	0.32	neutral	4.03	23.70	deleterious	0.29	0.45	0.61	disease	0.86	disease	0.54	disease	0.77	disease	5	0.93	neutral	0.18	neutral	1	deleterious	0.80	deleterious	-1.72	low_impact	-0.05	medium_impact	1.18	medium_impact	0.89	0.9	26.99	25.17	0.26	N	0.78	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14433	14433	C	A	MI.23682	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	241	81	A	S	Gca/Tca	-0.04	0	0	benign	0.18	neutral	0.73	neutral	2.36	neutral	0.6	neutral	-0.88	neutral_impact	0.78	0.88	neutral	0.94	neutral	0.49	7.36	deleterious	0.45	0.55	0.36	neutral	0.24	neutral	0.21	neutral	0.45	neutral	1	0.16	neutral	0.78	deleterious	-6	neutral	0.22	neutral	-0.19	medium_impact	0.45	medium_impact	-0.49	medium_impact	0.89	0.9	26.99	25.17	0.34	N	0.59	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14433	14433	C	T	MI.23683	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	241	81	A	T	Gca/Aca	-0.04	0	0	benign	0.02	neutral	0.54	neutral	2.34	neutral	0.34	neutral	0.28	neutral_impact	0.35	0.97	neutral	0.96	neutral	-0.15	1.39	neutral	0.55	0.6	0.24	neutral	0.33	neutral	0.24	neutral	0.45	neutral	1	0.43	neutral	0.76	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.25	medium_impact	-0.85	medium_impact	0.87	0.9	26.99	25.17	0.34	N	0.30	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14434	14434	C	A	MI.23684	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	240	80	E	D	gaG/gaT	-0.5	0	0	benign	0.24	neutral	0.57	neutral	2.19	neutral	-2.38	deleterious	-2.97	medium_impact	2.77	0.78	neutral	0.4	neutral	4.11	23.70	deleterious	0.44	0.55	0.35	neutral	0.82	disease	0.49	neutral	0.65	disease	3	0.32	neutral	0.67	deleterious	-3	neutral	0.34	neutral	-0.34	medium_impact	0.27	medium_impact	1.18	medium_impact	0.84	0.9	25.66	23.52	0.24	N	0.83	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14434	14434	C	G	MI.23685	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	240	80	E	D	gaG/gaC	-0.5	0	0	benign	0.24	neutral	0.57	neutral	2.19	neutral	-2.38	deleterious	-2.97	medium_impact	2.77	0.78	neutral	0.4	neutral	3.89	23.50	deleterious	0.44	0.55	0.35	neutral	0.82	disease	0.49	neutral	0.65	disease	3	0.32	neutral	0.67	deleterious	-3	neutral	0.34	neutral	-0.34	medium_impact	0.27	medium_impact	1.18	medium_impact	0.84	0.9	25.66	23.52	0.25	N	0.83	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14435	14435	T	A	MI.23686	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	239	80	E	V	gAg/gTg	-0.73	0	0	probably_damaging	0.98	neutral	0.28	neutral	2.19	deleterious	-3.87	deleterious	-6.97	medium_impact	3.12	0.69	neutral	0.49	neutral	4.58	24.40	deleterious	0.38	0.5	0.66	disease	0.9	disease	0.55	disease	0.57	disease	1	0.99	deleterious	0.15	neutral	1	deleterious	0.86	deleterious	-2.35	low_impact	-0.02	medium_impact	1.47	medium_impact	0.85	0.9	25.66	23.52	0.34	N	0.72	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14435	14435	T	C	MI.23687	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	239	80	E	G	gAg/gGg	-0.73	0	0	probably_damaging	0.96	neutral	0.37	neutral	2.19	deleterious	-3.55	deleterious	-6.96	medium_impact	2.89	0.67	neutral	0.5	neutral	4.18	23.80	deleterious	0.5	0.6	0.55	disease	0.84	disease	0.59	disease	0.69	disease	4	0.96	neutral	0.21	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	0.08	medium_impact	1.28	medium_impact	0.80	0.85	25.66	23.52	0.29	N	0.29	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14435	14435	T	G	MI.23688	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	239	80	E	A	gAg/gCg	-0.73	0	0	probably_damaging	0.93	neutral	0.7	neutral	2.23	neutral	-2.68	deleterious	-5.97	medium_impact	3.12	0.65	neutral	0.49	neutral	4.05	23.70	deleterious	0.41	0.5	0.47	neutral	0.84	disease	0.57	disease	0.69	disease	4	0.92	neutral	0.39	neutral	1	deleterious	0.80	deleterious	-1.83	low_impact	0.41	medium_impact	1.47	medium_impact	0.77	0.85	25.66	23.52	0.28	N	0.64	NA	NA	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14436	14436	C	G	MI.23689	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	238	80	E	Q	Gag/Cag	1.79	0.07	0	probably_damaging	0.97	neutral	0.54	neutral	2.21	neutral	-2.8	deleterious	-2.99	medium_impact	3.03	0.72	neutral	0.48	neutral	3.61	23.20	deleterious	0.52	0.6	0.45	neutral	0.79	disease	0.53	disease	0.55	disease	1	0.96	neutral	0.29	neutral	1	deleterious	0.79	deleterious	-2.18	low_impact	0.25	medium_impact	1.4	medium_impact	0.91	0.95	25.66	23.52	0.31	N	0.87	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6130	6130	G	A	MI.2369	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	227	76	G	E	gGa/gAa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	1.87	deleterious	-5.37	deleterious	-5.32	high_impact	4.78	0.46	damaging	0.16	damaging	3.74	23.30	deleterious	0.16	0.55	0.47	neutral	0.9	disease	0.78	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.70	0.9	1.95	6.7	0.68	P	0.93	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14436	14436	C	T	MI.23690	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	238	80	E	K	Gag/Aag	1.79	0.07	0	probably_damaging	0.93	neutral	0.86	neutral	2.31	neutral	-2.02	deleterious	-3.99	medium_impact	3.12	0.78	neutral	0.4	neutral	4.76	24.70	deleterious	0.62	0.65	0.25	neutral	0.9	disease	0.6	disease	0.71	disease	4	0.92	neutral	0.47	neutral	1	deleterious	0.79	deleterious	-1.83	low_impact	0.64	medium_impact	1.47	medium_impact	0.93	0.95	25.66	23.52	0.33	N	0.93	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14438	14438	G	T	MI.23691	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	236	79	P	H	cCt/cAt	-1.42	0	0	probably_damaging	1	neutral	0.52	neutral	2.27	deleterious	-5.4	deleterious	-8.97	high_impact	3.65	0.52	damaging	0.06	damaging	3.54	23.10	deleterious	0.42	0.55	0.92	disease	0.89	disease	0.73	disease	0.83	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.23	medium_impact	1.92	medium_impact	0.59	0.8	49.56	8.5	0.36	N	0.73	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14438	14438	G	C	MI.23692	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	236	79	P	R	cCt/cGt	-1.42	0	0	probably_damaging	1	neutral	0.36	neutral	2.29	deleterious	-4.07	deleterious	-8.98	high_impact	4	0.44	damaging	0.06	damaging	3.36	22.90	deleterious	0.36	0.5	0.86	disease	0.91	disease	0.71	disease	0.81	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.07	medium_impact	2.21	high_impact	0.57	0.8	49.56	8.5	0.43	N	0.66	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14438	14438	G	A	MI.23693	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	236	79	P	L	cCt/cTt	-1.42	0	0	probably_damaging	1	neutral	0.67	neutral	2.33	deleterious	-4.49	deleterious	-9.97	medium_impact	3.31	0.55	damaging	0.07	damaging	4.07	23.70	deleterious	0.37	0.5	0.85	disease	0.91	disease	0.64	disease	0.77	disease	5	1	deleterious	0.34	neutral	1	deleterious	0.91	deleterious	-3.55	low_impact	0.38	medium_impact	1.63	medium_impact	0.71	0.85	49.56	8.5	0.32	N	0.96	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14439	14439	G	A	MI.23694	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	235	79	P	S	Cct/Tct	3.63	0.99	0	probably_damaging	1	neutral	0.47	neutral	2.37	deleterious	-3.64	deleterious	-7.98	high_impact	4	0.51	damaging	0.08	damaging	3.62	23.20	deleterious	0.42	0.5	0.77	disease	0.9	disease	0.66	disease	0.75	disease	5	1	deleterious	0.24	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	0.18	medium_impact	2.21	high_impact	0.49	0.8	49.56	8.5	0.55	P	0.79	NA	NA	0.74	.	.	.	.	.	.	.	.	.	G14439A	Mitochondrial Respiratory Chain Disorder	+	-	Reported	1	.	P	P	damaging
chrM	14439	14439	G	C	MI.23695	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	235	79	P	A	Cct/Gct	3.63	0.99	0	probably_damaging	1	neutral	0.54	neutral	2.33	deleterious	-3.5	deleterious	-7.98	high_impact	4	0.54	damaging	0.1	damaging	2.78	21.30	deleterious	0.3	0.45	0.74	disease	0.81	disease	0.67	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0.25	medium_impact	2.21	high_impact	0.65	0.8	49.56	8.5	0.52	N	0.71	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14439	14439	G	T	MI.23696	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	235	79	P	T	Cct/Act	3.63	0.99	0	probably_damaging	1	neutral	0.42	neutral	2.46	deleterious	-4.07	deleterious	-7.98	high_impact	4	0.52	damaging	0.07	damaging	3.21	22.70	deleterious	0.38	0.5	0.81	disease	0.89	disease	0.69	disease	0.77	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.13	medium_impact	2.21	high_impact	0.71	0.85	49.56	8.5	0.42	N	0.88	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14441	14441	T	C	MI.23697	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	233	78	Y	C	tAt/tGt	-1.19	0	0	probably_damaging	0.99	neutral	0.15	neutral	2.28	deleterious	-6.14	deleterious	-8.85	medium_impact	3.29	0.49	damaging	0.16	damaging	3.38	22.90	deleterious	0.36	0.5	0.84	disease	0.89	disease	0.74	disease	0.82	disease	6	0.99	deleterious	0.08	neutral	1	deleterious	0.88	deleterious	-2.63	low_impact	-0.21	medium_impact	1.62	medium_impact	0.10	0.8	49.56	8.89	0.35	N	1.00	NA	NA	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14441	14441	T	G	MI.23698	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	233	78	Y	S	tAt/tCt	-1.19	0	0	probably_damaging	0.95	neutral	0.42	neutral	2.41	deleterious	-4.3	deleterious	-8.81	high_impact	3.83	0.49	damaging	0.29	neutral	3.94	23.50	deleterious	0.35	0.5	0.6	disease	0.88	disease	0.71	disease	0.79	disease	6	0.94	neutral	0.24	neutral	2	deleterious	0.84	deleterious	-1.97	low_impact	0.13	medium_impact	2.07	high_impact	0.28	0.8	49.56	8.89	0.42	N	0.96	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14441	14441	T	A	MI.23699	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	233	78	Y	F	tAt/tTt	-1.19	0	0	possibly_damaging	0.9	neutral	0.79	neutral	2.34	neutral	-1.04	deleterious	-3.94	medium_impact	2.22	0.82	neutral	0.66	neutral	3.66	23.20	deleterious	0.39	0.5	0.24	neutral	0.42	neutral	0.54	disease	0.4	neutral	2	0.88	neutral	0.45	neutral	0	NA	0.71	deleterious	-1.67	low_impact	0.53	medium_impact	0.72	medium_impact	0.38	0.8	49.56	8.89	0.23	N	0.80	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8638	8638	A	G	MI.237	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	112	38	I	V	Atc/Gtc	-0.1	0	0	probably_damaging	0.93	neutral	0.27	neutral	4.48	neutral	0.63	neutral	-0.59	low_impact	0.92	0.91	neutral	0.97	neutral	1.46	13.10	neutral	0.63	0.7	0.32	neutral	0.16	neutral	0.3	neutral	0.3	neutral	4	0.94	neutral	0.17	neutral	-2	neutral	0.59	deleterious	-1.82	low_impact	0.05	medium_impact	-0.31	medium_impact	0.39	0.9	15.49	18.25	0.45	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6132	6132	G	A	MI.2370	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	229	77	G	S	Ggc/Agc	-4.73	0	0	probably_damaging	1	deleterious	0	neutral	2.12	deleterious	-4.2	deleterious	-4	high_impact	4.82	0.59	damaging	0.18	damaging	4.05	23.70	deleterious	0.25	0.55	0.62	disease	0.83	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.70	0.9	2.14	6.61	0.63	P	0.73	polymorphism	0.51	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14442	14442	A	G	MI.23700	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	232	78	Y	H	Tat/Cat	0.64	0.02	0	benign	0.14	neutral	0.5	neutral	2.31	deleterious	-4.37	deleterious	-4.71	medium_impact	2	0.81	neutral	0.61	neutral	1.69	14.36	neutral	0.55	0.6	0.61	disease	0.74	disease	0.7	disease	0.63	disease	3	0.41	neutral	0.68	deleterious	-3	neutral	0.34	neutral	-0.07	medium_impact	0.21	medium_impact	0.54	medium_impact	0.27	0.8	49.56	8.89	0.26	N	0.98	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14442	14442	A	T	MI.23701	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	232	78	Y	N	Tat/Aat	0.64	0.02	0	probably_damaging	0.93	neutral	0.27	neutral	2.33	deleterious	-4.84	deleterious	-8.77	high_impact	3.83	0.55	damaging	0.27	damaging	3.52	23.10	deleterious	0.39	0.5	0.66	disease	0.9	disease	0.72	disease	0.8	disease	6	0.94	neutral	0.17	neutral	2	deleterious	0.83	deleterious	-1.83	low_impact	-0.03	medium_impact	2.07	high_impact	0.22	0.8	49.56	8.89	0.42	N	1.00	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14442	14442	A	C	MI.23702	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	232	78	Y	D	Tat/Gat	0.64	0.02	0	probably_damaging	0.96	neutral	0.2	neutral	2.32	deleterious	-4.01	deleterious	-9.79	medium_impact	3.48	0.53	damaging	0.3	neutral	3.51	23.10	deleterious	0.32	0.5	0.35	neutral	0.91	disease	0.73	disease	0.8	disease	6	0.97	neutral	0.12	neutral	1	deleterious	0.81	deleterious	-2.06	low_impact	-0.13	medium_impact	1.78	medium_impact	0.32	0.8	49.56	8.89	0.41	N	0.97	NA	NA	0.62	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14443	14443	C	G	MI.23703	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	231	77	E	D	gaG/gaC	2.94	0.04	0	probably_damaging	1	neutral	0.25	neutral	2.17	neutral	-1.63	neutral	-2.35	medium_impact	2.6	0.79	neutral	0.41	neutral	2.83	21.50	deleterious	0.42	0.55	0.24	neutral	0.69	disease	0.49	neutral	0.52	disease	0	1	deleterious	0.13	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	-0.06	medium_impact	1.04	medium_impact	0.78	0.85	27.43	20.89	0.36	N	0.82	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14443	14443	C	A	MI.23704	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	231	77	E	D	gaG/gaT	2.94	0.04	0	probably_damaging	1	neutral	0.25	neutral	2.17	neutral	-1.63	neutral	-2.35	medium_impact	2.6	0.79	neutral	0.41	neutral	3.07	22.40	deleterious	0.42	0.55	0.24	neutral	0.69	disease	0.49	neutral	0.52	disease	0	1	deleterious	0.13	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	-0.06	medium_impact	1.04	medium_impact	0.78	0.85	27.43	20.89	0.38	N	0.82	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14444	14444	T	C	MI.23705	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	230	77	E	G	gAg/gGg	-6.47	0	0	probably_damaging	1	neutral	0.35	neutral	2.14	neutral	-2.48	deleterious	-5.32	medium_impact	3.4	0.65	neutral	0.17	damaging	4.23	23.90	deleterious	0.49	0.55	0.34	neutral	0.71	disease	0.59	disease	0.72	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	0.06	medium_impact	1.71	medium_impact	0.72	0.85	27.43	20.89	0.32	N	0.73	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14444	14444	T	A	MI.23706	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	230	77	E	V	gAg/gTg	-6.47	0	0	probably_damaging	1	neutral	0.52	neutral	2.14	neutral	-2.74	deleterious	-5.3	medium_impact	2.6	0.75	neutral	0.32	neutral	4.75	24.70	deleterious	0.35	0.5	0.35	neutral	0.81	disease	0.58	disease	0.77	disease	5	1	deleterious	0.26	neutral	1	deleterious	0.77	deleterious	-3.55	low_impact	0.23	medium_impact	1.04	medium_impact	0.85	0.9	27.43	20.89	0.28	N	0.82	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14444	14444	T	G	MI.23707	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	230	77	E	A	gAg/gCg	-6.47	0	0	probably_damaging	1	neutral	0.57	neutral	2.17	neutral	-1.72	deleterious	-4.33	medium_impact	2.36	0.67	neutral	0.37	neutral	4.02	23.60	deleterious	0.4	0.5	0.21	neutral	0.61	disease	0.49	neutral	0.45	neutral	1	1	deleterious	0.29	neutral	1	deleterious	0.73	deleterious	-3.55	low_impact	0.27	medium_impact	0.84	medium_impact	0.76	0.85	27.43	20.89	0.26	N	0.63	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14445	14445	C	T	MI.23708	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	229	77	E	K	Gag/Aag	-0.04	0	0	probably_damaging	1	neutral	0.37	neutral	2.42	neutral	0.57	neutral	-2.47	medium_impact	3.4	0.68	neutral	0.29	neutral	4.80	24.80	deleterious	0.46	0.55	0.13	neutral	0.77	disease	0.56	disease	0.74	disease	5	1	deleterious	0.19	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	0.08	medium_impact	1.71	medium_impact	0.90	0.95	27.43	20.89	0.34	N	0.76	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14445	14445	C	G	MI.23709	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	229	77	E	Q	Gag/Cag	-0.04	0	0	probably_damaging	1	neutral	0.33	neutral	2.2	neutral	-1.22	neutral	-0.64	low_impact	1.65	0.85	neutral	0.83	neutral	2.00	16.24	deleterious	0.53	0.6	0.16	neutral	0.43	neutral	0.25	neutral	0.41	neutral	2	1	deleterious	0.17	neutral	-2	neutral	0.69	deleterious	-3.55	low_impact	0.04	medium_impact	0.24	medium_impact	0.87	0.9	27.43	20.89	0.37	N	0.06	NA	NA	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6132	6132	G	C	MI.2371	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	229	77	G	R	Ggc/Cgc	-4.73	0	0	probably_damaging	1	deleterious	0	neutral	2.05	deleterious	-7.56	deleterious	-5.34	high_impact	5.17	0.51	damaging	0.12	damaging	3.86	23.50	deleterious	0.13	0.55	0.78	disease	0.93	disease	0.77	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.80	0.9	2.14	6.61	0.57	P	0.95	disease_causing	0.67	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14446	14446	C	G	MI.23710	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	228	76	E	D	gaG/gaC	-0.04	0	0	benign	0.05	neutral	0.58	neutral	2.3	neutral	-1.12	deleterious	-2.52	low_impact	1.04	0.88	neutral	0.79	neutral	2.76	21.10	deleterious	0.33	0.5	0.17	neutral	0.52	disease	0.32	neutral	0.42	neutral	2	0.36	neutral	0.77	deleterious	-6	neutral	0.19	neutral	0.38	medium_impact	0.28	medium_impact	-0.27	medium_impact	0.85	0.9	18.58	16.92	0.3	N	0.83	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14446	14446	C	A	MI.23711	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	228	76	E	D	gaG/gaT	-0.04	0	0	benign	0.05	neutral	0.58	neutral	2.3	neutral	-1.12	deleterious	-2.52	low_impact	1.04	0.88	neutral	0.79	neutral	3.01	22.30	deleterious	0.33	0.5	0.17	neutral	0.52	disease	0.32	neutral	0.42	neutral	2	0.36	neutral	0.77	deleterious	-6	neutral	0.19	neutral	0.38	medium_impact	0.28	medium_impact	-0.27	medium_impact	0.85	0.9	18.58	16.92	0.3	N	0.83	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14447	14447	T	G	MI.23712	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	227	76	E	A	gAg/gCg	-3.26	0	0	possibly_damaging	0.86	neutral	0.65	neutral	2.29	deleterious	-3.57	deleterious	-5.84	high_impact	3.73	0.7	neutral	0.61	neutral	4.04	23.70	deleterious	0.31	0.45	0.42	neutral	0.85	disease	0.68	disease	0.75	disease	5	0.84	neutral	0.4	neutral	1	deleterious	0.76	deleterious	-1.52	low_impact	0.36	medium_impact	1.99	medium_impact	0.78	0.85	18.58	16.92	0.32	N	0.64	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14447	14447	T	A	MI.23713	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	227	76	E	V	gAg/gTg	-3.26	0	0	probably_damaging	0.96	neutral	0.28	neutral	2.43	deleterious	-5.07	deleterious	-6.84	high_impact	3.73	0.66	neutral	0.51	neutral	4.57	24.40	deleterious	0.24	0.45	0.64	disease	0.92	disease	0.72	disease	0.8	disease	6	0.97	neutral	0.16	neutral	2	deleterious	0.86	deleterious	-2.06	low_impact	-0.02	medium_impact	1.99	medium_impact	0.78	0.85	18.58	16.92	0.38	N	0.72	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14447	14447	T	C	MI.23714	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	227	76	E	G	gAg/gGg	-3.26	0	0	possibly_damaging	0.86	neutral	0.35	neutral	2.26	deleterious	-3.91	deleterious	-6.7	medium_impact	3.39	0.7	neutral	0.78	neutral	4.17	23.80	deleterious	0.38	0.5	0.49	neutral	0.87	disease	0.7	disease	0.77	disease	5	0.88	neutral	0.25	neutral	0	NA	0.77	deleterious	-1.52	low_impact	0.06	medium_impact	1.7	medium_impact	0.81	0.85	18.58	16.92	0.37	N	0.29	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14448	14448	C	G	MI.23715	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	226	76	E	Q	Gag/Cag	2.25	0.97	0	probably_damaging	0.94	neutral	0.5	neutral	2.26	deleterious	-3.52	deleterious	-2.92	high_impact	3.73	0.71	neutral	0.48	neutral	3.58	23.20	deleterious	0.4	0.5	0.41	neutral	0.83	disease	0.69	disease	0.73	disease	5	0.93	neutral	0.28	neutral	2	deleterious	0.77	deleterious	-1.89	low_impact	0.21	medium_impact	1.99	medium_impact	0.74	0.85	18.58	16.92	0.49	N	0.87	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14448	14448	C	T	MI.23716	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	226	76	E	K	Gag/Aag	2.25	0.97	0	possibly_damaging	0.86	neutral	0.8	neutral	2.3	deleterious	-3.33	deleterious	-3.92	medium_impact	3.39	0.69	neutral	0.37	neutral	4.74	24.70	deleterious	0.39	0.5	0.27	neutral	0.92	disease	0.66	disease	0.77	disease	5	0.84	neutral	0.47	deleterious	0	NA	0.78	deleterious	-1.52	low_impact	0.54	medium_impact	1.7	medium_impact	0.90	0.95	18.58	16.92	0.44	N	0.93	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14449	14449	A	T	MI.23717	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	225	75	I	M	atT/atA	4.31	0.98	0	probably_damaging	0.97	neutral	0.21	neutral	2.3	neutral	-1.18	neutral	0.29	low_impact	1.02	0.84	neutral	0.83	neutral	1.77	14.83	neutral	0.65	0.7	0.36	neutral	0.51	disease	0.11	neutral	0.43	neutral	1	0.98	deleterious	0.12	neutral	-2	neutral	0.68	deleterious	-2.18	low_impact	-0.11	medium_impact	-0.29	medium_impact	0.72	0.85	50.44	8.5	0.58	P	0.71	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14449	14449	A	C	MI.23718	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	225	75	I	M	atT/atG	4.31	0.98	0	probably_damaging	0.97	neutral	0.21	neutral	2.3	neutral	-1.18	neutral	0.29	low_impact	1.02	0.84	neutral	0.83	neutral	1.63	14.02	neutral	0.65	0.7	0.36	neutral	0.51	disease	0.11	neutral	0.43	neutral	1	0.98	deleterious	0.12	neutral	-2	neutral	0.68	deleterious	-2.18	low_impact	-0.11	medium_impact	-0.29	medium_impact	0.72	0.85	50.44	8.5	0.56	P	0.71	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14450	14450	A	T	MI.23719	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	224	75	I	N	aTt/aAt	-6.7	0	0	probably_damaging	0.98	neutral	0.61	neutral	2.44	neutral	2.13	neutral	-0.72	medium_impact	2.34	0.64	neutral	0.54	neutral	4.16	23.80	deleterious	0.46	0.55	0.4	neutral	0.88	disease	0.41	neutral	0.77	disease	5	0.98	neutral	0.32	neutral	1	deleterious	0.77	deleterious	-2.35	low_impact	0.31	medium_impact	0.82	medium_impact	0.48	0.8	50.44	8.5	0.31	N	0.79	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6132	6132	G	T	MI.2372	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	229	77	G	C	Ggc/Tgc	-4.73	0	0	probably_damaging	1	deleterious	0	neutral	2.07	deleterious	-6.1	deleterious	-6.01	high_impact	5.17	0.48	damaging	0.14	damaging	4.09	23.70	deleterious	0.15	0.55	0.86	disease	0.91	disease	0.65	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.55	0.9	2.14	6.61	0.56	P	0.98	disease_causing	0.8	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14450	14450	A	C	MI.23720	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	224	75	I	S	aTt/aGt	-6.7	0	0	probably_damaging	0.96	neutral	0.8	neutral	2.42	neutral	1.9	neutral	0.41	neutral_impact	0.78	0.88	neutral	0.91	neutral	3.94	23.50	deleterious	0.43	0.55	0.25	neutral	0.72	disease	0.17	neutral	0.51	disease	0	0.95	neutral	0.42	neutral	-2	neutral	0.69	deleterious	-2.06	low_impact	0.54	medium_impact	-0.49	medium_impact	0.40	0.8	50.44	8.5	0.34	N	0.67	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14450	14450	A	G	MI.23721	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	224	75	I	T	aTt/aCt	-6.7	0	0	possibly_damaging	0.89	neutral	0.64	neutral	2.34	neutral	0.58	neutral	2.96	neutral_impact	-0.24	0.9	neutral	0.91	neutral	0.87	9.91	deleterious	0.38	0.5	0.09	neutral	0.39	neutral	0.12	neutral	0.41	neutral	2	0.87	neutral	0.38	neutral	-3	neutral	0.59	deleterious	-1.63	low_impact	0.35	medium_impact	-1.34	low_impact	0.39	0.8	50.44	8.5	0.34	N	0.23	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14451	14451	T	A	MI.23722	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	223	75	I	F	Att/Ttt	0.18	0	0	probably_damaging	0.96	neutral	0.42	neutral	2.3	neutral	-1.4	neutral	-1.37	medium_impact	2	0.68	neutral	0.56	neutral	4.33	24.00	deleterious	0.45	0.55	0.37	neutral	0.78	disease	0.37	neutral	0.64	disease	3	0.96	neutral	0.23	neutral	1	deleterious	0.73	deleterious	-2.06	low_impact	0.13	medium_impact	0.54	medium_impact	0.54	0.8	50.44	8.5	0.32	N	0.66	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14451	14451	T	C	MI.23723	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	223	75	I	V	Att/Gtt	0.18	0	0	benign	0.15	neutral	0.47	neutral	2.32	neutral	-0.11	neutral	0.54	low_impact	1.45	0.66	neutral	0.67	neutral	1.82	15.08	deleterious	0.53	0.6	0.15	neutral	0.42	neutral	0.37	neutral	0.41	neutral	2	0.44	neutral	0.66	deleterious	-6	neutral	0.17	neutral	-0.11	medium_impact	0.18	medium_impact	0.08	medium_impact	0.46	0.8	50.44	8.5	0.42	N	0.58	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14451	14451	T	G	MI.23724	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	223	75	I	L	Att/Ctt	0.18	0	0	possibly_damaging	0.67	neutral	0.58	neutral	2.33	neutral	0.11	neutral	-0.1	medium_impact	2	0.68	neutral	0.55	neutral	4.04	23.70	deleterious	0.42	0.5	0.19	neutral	0.6	disease	0.32	neutral	0.51	disease	0	0.62	neutral	0.46	neutral	0	NA	0.49	deleterious	-1.08	low_impact	0.28	medium_impact	0.54	medium_impact	0.55	0.8	50.44	8.5	0.32	N	0.64	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14453	14453	G	C	MI.23725	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	221	74	A	G	gCt/gGt	-4.17	0	0	probably_damaging	1	neutral	0.4	neutral	2.22	deleterious	-3.43	deleterious	-3.79	high_impact	3.92	0.66	neutral	0.13	damaging	3.60	23.20	deleterious	0.29	0.45	0.52	disease	0.87	disease	0.72	disease	0.79	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	0.11	medium_impact	2.14	high_impact	0.81	0.85	16.81	15.96	0.31	N	0.80	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14453	14453	G	A	MI.23726	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	221	74	A	V	gCt/gTt	-4.17	0	0	probably_damaging	1	neutral	0.56	neutral	2.3	neutral	-2.72	deleterious	-3.92	medium_impact	2.54	0.29	damaging	0.32	neutral	4.14	23.80	deleterious	0.48	0.55	0.61	disease	0.87	disease	0.57	disease	0.56	disease	1	1	deleterious	0.28	neutral	1	deleterious	0.85	deleterious	-3.55	low_impact	0.27	medium_impact	0.99	medium_impact	0.86	0.9	16.81	15.96	0.81	P	0.81	NA	NA	0.60	rs199476107	Pathogenic	Juvenile_myopathy,_encephalopathy,_lactic_acidosis_AND_stroke	24731	MedGen:C0162671,OMIM:540000,Orphanet:ORPHA550,SNOMED_CT:39925003	.	COSM1155561	CPD	0.15	G14453A	MELAS / Leigh Disease	-	+	Reported	5	P	P	P	damaging
chrM	14453	14453	G	T	MI.23727	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	221	74	A	D	gCt/gAt	-4.17	0	0	probably_damaging	1	neutral	0.37	neutral	2.2	deleterious	-4.36	deleterious	-5.65	high_impact	3.92	0.68	neutral	0.05	damaging	3.98	23.60	deleterious	0.26	0.45	0.72	disease	0.95	disease	0.8	disease	0.91	disease	8	1	deleterious	0.19	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	0.08	medium_impact	2.14	high_impact	0.81	0.85	16.81	15.96	0.35	N	0.96	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14454	14454	C	T	MI.23728	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	220	74	A	T	Gct/Act	2.94	0.22	0	probably_damaging	1	neutral	0.51	neutral	2.34	neutral	-2.66	deleterious	-3.73	medium_impact	2.67	0.68	neutral	0.12	damaging	4.39	24.10	deleterious	0.54	0.6	0.49	neutral	0.89	disease	0.64	disease	0.57	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.85	deleterious	-3.55	low_impact	0.22	medium_impact	1.1	medium_impact	0.79	0.85	16.81	15.96	0.3	N	0.92	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14454	14454	C	G	MI.23729	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	220	74	A	P	Gct/Cct	2.94	0.22	0	probably_damaging	1	neutral	0.3	neutral	2.2	deleterious	-4.49	deleterious	-4.79	high_impact	3.57	0.72	neutral	0.07	damaging	4.03	23.60	deleterious	0.2	0.45	0.7	disease	0.93	disease	0.82	disease	0.89	disease	8	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0	medium_impact	1.85	medium_impact	0.82	0.85	16.81	15.96	0.51	N	0.97	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6133	6133	G	T	MI.2373	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	230	77	G	V	gGc/gTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.1	deleterious	-4.57	deleterious	-6.01	high_impact	5.17	0.49	damaging	0.16	damaging	3.64	23.20	deleterious	0.13	0.55	0.59	disease	0.92	disease	0.67	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.56	0.9	2.14	6.61	0.64	P	0.93	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14454	14454	C	A	MI.23730	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	220	74	A	S	Gct/Tct	2.94	0.22	0	probably_damaging	1	neutral	0.7	neutral	2.51	neutral	-1.36	deleterious	-2.6	medium_impact	2.44	0.77	neutral	0.73	neutral	3.08	22.50	deleterious	0.4	0.5	0.27	neutral	0.88	disease	0.54	disease	0.56	disease	1	1	deleterious	0.35	neutral	1	deleterious	0.81	deleterious	-3.55	low_impact	0.41	medium_impact	0.9	medium_impact	0.90	0.95	16.81	15.96	0.3	N	0.93	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14455	14455	C	A	MI.23731	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	219	73	M	I	atG/atT	-0.27	0	0	probably_damaging	0.99	neutral	0.34	neutral	2.04	neutral	-0.5	deleterious	-3.84	medium_impact	3.23	0.63	neutral	0.07	damaging	2.17	17.32	deleterious	0.54	0.6	0.25	neutral	0.87	disease	0.54	disease	0.78	disease	6	0.99	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-2.63	low_impact	0.05	medium_impact	1.57	medium_impact	0.77	0.85	25.22	18.16	0.31	N	0.79	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14455	14455	C	G	MI.23732	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	219	73	M	I	atG/atC	-0.27	0	0	probably_damaging	0.99	neutral	0.34	neutral	2.04	neutral	-0.5	deleterious	-3.84	medium_impact	3.23	0.63	neutral	0.07	damaging	1.83	15.19	deleterious	0.54	0.6	0.25	neutral	0.87	disease	0.54	disease	0.78	disease	6	0.99	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-2.63	low_impact	0.05	medium_impact	1.57	medium_impact	0.77	0.85	25.22	18.16	0.31	N	0.79	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14456	14456	A	G	MI.23733	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	218	73	M	T	aTg/aCg	-6.01	0	0	probably_damaging	0.99	neutral	0.33	neutral	1.98	deleterious	-3.1	deleterious	-5.88	high_impact	3.58	0.66	neutral	0.1	damaging	1.49	13.28	neutral	0.44	0.55	0.4	neutral	0.87	disease	0.66	disease	0.79	disease	6	0.99	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-2.63	low_impact	0.04	medium_impact	1.86	medium_impact	0.49	0.8	25.22	18.16	0.31	N	0.88	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14456	14456	A	T	MI.23734	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	218	73	M	K	aTg/aAg	-6.01	0	0	probably_damaging	0.99	neutral	0.28	neutral	1.92	deleterious	-4.2	deleterious	-5.91	high_impact	3.58	0.62	neutral	0.06	damaging	3.50	23.10	deleterious	0.22	0.45	0.44	neutral	0.93	disease	0.73	disease	0.83	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-2.63	low_impact	-0.02	medium_impact	1.86	medium_impact	0.56	0.8	25.22	18.16	0.32	N	0.93	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14457	14457	T	A	MI.23735	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	217	73	M	L	Atg/Ttg	3.17	0.03	0	probably_damaging	0.98	neutral	1	neutral	2.42	neutral	1.61	deleterious	-2.82	neutral_impact	0.75	0.84	neutral	0.51	neutral	0.77	9.25	deleterious	0.45	0.55	0.09	neutral	0.4	neutral	0.25	neutral	0.41	neutral	2	0.98	neutral	0.51	deleterious	-2	neutral	0.65	deleterious	-2.35	low_impact	1.87	high_impact	-0.51	medium_impact	0.65	0.8	25.22	18.16	0.29	N	0.36	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14457	14457	T	C	MI.23736	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	217	73	M	V	Atg/Gtg	3.17	0.03	0	probably_damaging	0.99	neutral	0.4	neutral	2.03	neutral	-1.15	deleterious	-3.88	medium_impact	3.23	0.78	neutral	0.12	damaging	0.77	9.29	deleterious	0.52	0.6	0.25	neutral	0.87	disease	0.56	disease	0.78	disease	6	0.99	deleterious	0.21	neutral	1	deleterious	0.78	deleterious	-2.63	low_impact	0.11	medium_impact	1.57	medium_impact	0.66	0.8	25.22	18.16	0.28	N	0.74	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14457	14457	T	G	MI.23737	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	217	73	M	L	Atg/Ctg	3.17	0.03	0	probably_damaging	0.98	neutral	1	neutral	2.42	neutral	1.61	deleterious	-2.82	neutral_impact	0.75	0.84	neutral	0.51	neutral	0.64	8.40	deleterious	0.45	0.55	0.09	neutral	0.4	neutral	0.25	neutral	0.41	neutral	2	0.98	neutral	0.51	deleterious	-2	neutral	0.65	deleterious	-2.35	low_impact	1.87	high_impact	-0.51	medium_impact	0.65	0.8	25.22	18.16	0.29	N	0.36	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14459	14459	G	A	MI.23738	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	215	72	A	V	gCg/gTg	-3.71	0	0	probably_damaging	1	neutral	0.3	neutral	2.27	neutral	-0.53	deleterious	-3.98	high_impact	3.61	0.08	damaging	0.15	damaging	4.08	23.70	deleterious	0.4	0.5	0.61	disease	0.92	disease	0.79	disease	0.84	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0	medium_impact	1.88	medium_impact	0.86	0.9	27.88	11.58	0.93	P	0.81	NA	NA	0.61	rs199476105	Pathogenic	Leber's_optic_atrophy|Leigh_syndrome|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency|Leber_hereditary_optic_neuropathy_with_dystonia	24728	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838951|MedGen:C1839040,OMIM:500001	.	.	.	.	G14459A	LDYT / Leigh Disease	+	+	Cfrm	26	P	P	P	damaging
chrM	14459	14459	G	T	MI.23739	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	215	72	A	E	gCg/gAg	-3.71	0	0	probably_damaging	1	neutral	0.25	neutral	2.16	deleterious	-3.61	deleterious	-4.98	high_impact	3.96	0.35	damaging	0.19	damaging	3.88	23.50	deleterious	0.15	0.4	0.7	disease	0.95	disease	0.82	disease	0.92	disease	8	1	deleterious	0.13	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.06	medium_impact	2.18	high_impact	0.80	0.85	27.88	11.58	0.63	P	0.99	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6133	6133	G	C	MI.2374	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	230	77	G	A	gGc/gCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.53	neutral	-1.25	deleterious	-4	medium_impact	3.33	0.66	neutral	0.3	neutral	2.98	22.20	deleterious	0.25	0.55	0.36	neutral	0.79	disease	0.56	disease	0.64	disease	3	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	1.98	medium_impact	0.71	0.9	2.14	6.61	0.47	N	0.64	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14459	14459	G	C	MI.23740	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	215	72	A	G	gCg/gGg	-3.71	0	0	probably_damaging	1	neutral	0.2	neutral	2.17	neutral	-2.95	deleterious	-3.98	high_impact	3.96	0.46	damaging	0.46	neutral	3.56	23.10	deleterious	0.25	0.45	0.53	disease	0.91	disease	0.78	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	-0.13	medium_impact	2.18	high_impact	0.81	0.85	27.88	11.58	0.55	N	0.80	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14460	14460	C	G	MI.23741	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	214	72	A	P	Gcg/Ccg	4.31	0.98	0	probably_damaging	1	neutral	0.22	neutral	2.16	deleterious	-4.01	deleterious	-4.98	high_impact	3.96	0.4	damaging	0.21	damaging	4.05	23.70	deleterious	0.2	0.45	0.7	disease	0.95	disease	0.86	disease	0.94	disease	9	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.1	medium_impact	2.18	high_impact	0.77	0.85	27.88	11.58	0.81	P	0.97	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14460	14460	C	A	MI.23742	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	214	72	A	S	Gcg/Tcg	4.31	0.98	0	probably_damaging	1	neutral	0.7	neutral	2.39	neutral	0.51	deleterious	-2.99	medium_impact	2.35	0.61	neutral	0.67	neutral	4.04	23.70	deleterious	0.33	0.5	0.3	neutral	0.68	disease	0.6	disease	0.51	disease	0	1	deleterious	0.35	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	0.41	medium_impact	0.83	medium_impact	0.85	0.9	27.88	11.58	0.53	N	0.93	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14460	14460	C	T	MI.23743	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	214	72	A	T	Gcg/Acg	4.31	0.98	0	probably_damaging	1	neutral	0.37	neutral	2.23	neutral	-1.16	deleterious	-3.98	high_impact	3.96	0.38	damaging	0.23	damaging	4.37	24.10	deleterious	0.38	0.5	0.5	neutral	0.92	disease	0.77	disease	0.82	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	0.08	medium_impact	2.18	high_impact	0.86	0.9	27.88	11.58	0.84	P	0.92	NA	NA	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14462	14462	G	T	MI.23744	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	212	71	T	K	aCa/aAa	-12.43	0	0	possibly_damaging	0.58	neutral	0.27	neutral	2.21	deleterious	-3.01	deleterious	-5.29	medium_impact	3.33	0.69	neutral	0.33	neutral	3.66	23.20	deleterious	0.16	0.45	0.46	neutral	0.87	disease	0.73	disease	0.82	disease	6	0.73	neutral	0.35	neutral	0	NA	0.68	deleterious	-0.92	medium_impact	-0.03	medium_impact	1.65	medium_impact	0.87	0.9	44.25	8.42	0.37	N	0.94	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14462	14462	G	A	MI.23745	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	212	71	T	M	aCa/aTa	-12.43	0	0	benign	0.26	neutral	0.21	neutral	2.24	neutral	-1.45	deleterious	-5.17	medium_impact	3.33	0.66	neutral	0.38	neutral	1.85	15.30	deleterious	0.26	0.45	0.61	disease	0.73	disease	0.67	disease	0.75	disease	5	0.75	neutral	0.48	deleterious	-3	neutral	0.42	neutral	-0.38	medium_impact	-0.11	medium_impact	1.65	medium_impact	0.86	0.9	44.25	8.42	0.38	N	0.90	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14463	14463	T	G	MI.23746	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	211	71	T	P	Aca/Cca	2.02	0.06	0	possibly_damaging	0.82	neutral	0.16	neutral	2.21	deleterious	-3.05	deleterious	-5.29	medium_impact	3.33	0.7	neutral	0.28	neutral	3.63	23.20	deleterious	0.15	0.4	0.58	disease	0.91	disease	0.73	disease	0.84	disease	7	0.91	neutral	0.17	neutral	0	NA	0.82	deleterious	-1.4	low_impact	-0.19	medium_impact	1.65	medium_impact	0.77	0.85	44.25	8.42	0.45	N	0.94	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14463	14463	T	C	MI.23747	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	211	71	T	A	Aca/Gca	2.02	0.06	0	benign	0.02	neutral	1	neutral	2.3	neutral	-0.24	deleterious	-3.79	neutral_impact	0.23	0.91	neutral	0.93	neutral	-0.05	2.09	deleterious	0.32	0.5	0.15	neutral	0.18	neutral	0.25	neutral	0.28	neutral	4	0.01	neutral	0.99	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	1.87	high_impact	-0.95	medium_impact	0.62	0.8	44.25	8.42	0.43	N	0.65	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14463	14463	T	A	MI.23748	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	211	71	T	S	Aca/Tca	2.02	0.06	0	benign	0.37	neutral	0.77	neutral	2.35	neutral	0.28	deleterious	-3.32	medium_impact	2.23	0.81	neutral	0.72	neutral	1.90	15.57	deleterious	0.37	0.5	0.2	neutral	0.64	disease	0.33	neutral	0.48	neutral	0	0.26	neutral	0.7	deleterious	-3	neutral	0.45	deleterious	-0.58	medium_impact	0.5	medium_impact	0.73	medium_impact	0.79	0.85	44.25	8.42	0.31	N	0.68	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14465	14465	G	C	MI.23749	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	209	70	T	S	aCt/aGt	-7.16	0	0	probably_damaging	1	neutral	0.76	neutral	2.36	neutral	0.4	deleterious	-3.99	low_impact	1.17	0.72	neutral	0.31	neutral	3.11	22.50	deleterious	0.48	0.55	0.11	neutral	0.17	neutral	0.26	neutral	0.24	neutral	5	1	deleterious	0.38	neutral	-2	neutral	0.65	deleterious	-3.55	low_impact	0.48	medium_impact	-0.16	medium_impact	0.89	0.9	49.12	8.68	0.3	N	0.87	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6133	6133	G	A	MI.2375	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	230	77	G	D	gGc/gAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.05	deleterious	-7.57	deleterious	-4.67	high_impact	5.17	0.45	damaging	0.14	damaging	3.73	23.30	deleterious	0.14	0.55	0.83	disease	0.89	disease	0.75	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.45	0.9	2.14	6.61	0.68	P	0.97	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14465	14465	G	A	MI.23750	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	209	70	T	I	aCt/aTt	-7.16	0	0	probably_damaging	1	neutral	0.42	neutral	2.4	neutral	0.81	deleterious	-5.98	high_impact	3.63	0.61	neutral	0.03	damaging	3.53	23.10	deleterious	0.37	0.5	0.63	disease	0.91	disease	0.66	disease	0.8	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.13	medium_impact	1.9	medium_impact	0.84	0.9	49.12	8.68	0.28	N	0.93	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14465	14465	G	T	MI.23751	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	209	70	T	N	aCt/aAt	-7.16	0	0	probably_damaging	1	neutral	0.3	neutral	2.22	deleterious	-3.09	deleterious	-4.99	high_impact	3.63	0.61	neutral	0.03	damaging	3.10	22.50	deleterious	0.31	0.5	0.54	disease	0.91	disease	0.65	disease	0.79	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	0	medium_impact	1.9	medium_impact	0.87	0.9	49.12	8.68	0.27	N	0.93	NA	NA	0.76	.	.	.	.	.	.	COSM1138266	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14466	14466	T	C	MI.23752	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	208	70	T	A	Act/Gct	4.08	1	0	probably_damaging	1	neutral	0.58	neutral	2.32	neutral	-0.04	deleterious	-4.98	medium_impact	2.83	0.64	neutral	0.14	damaging	3.33	22.90	deleterious	0.55	0.6	0.29	neutral	0.79	disease	0.53	disease	0.68	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	0.28	medium_impact	1.23	medium_impact	0.79	0.85	49.12	8.68	0.48	N	0.68	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14466	14466	T	G	MI.23753	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	208	70	T	P	Act/Cct	4.08	1	0	probably_damaging	1	neutral	0.19	neutral	2.22	deleterious	-3.39	deleterious	-5.98	high_impact	3.63	0.67	neutral	0.03	damaging	3.67	23.30	deleterious	0.16	0.45	0.61	disease	0.95	disease	0.75	disease	0.91	disease	8	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.14	medium_impact	1.9	medium_impact	0.76	0.85	49.12	8.68	0.61	P	0.97	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14466	14466	T	A	MI.23754	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	208	70	T	S	Act/Tct	4.08	1	0	probably_damaging	1	neutral	0.76	neutral	2.36	neutral	0.4	deleterious	-3.99	low_impact	1.17	0.72	neutral	0.31	neutral	3.70	23.30	deleterious	0.48	0.55	0.11	neutral	0.17	neutral	0.26	neutral	0.24	neutral	5	1	deleterious	0.38	neutral	-2	neutral	0.65	deleterious	-3.55	low_impact	0.48	medium_impact	-0.16	medium_impact	0.89	0.9	49.12	8.68	0.42	N	0.87	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14468	14468	T	A	MI.23755	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	206	69	Y	F	tAt/tTt	2.48	1	0	probably_damaging	1	neutral	0.51	neutral	2.55	neutral	0.56	deleterious	-3.99	medium_impact	3.46	0.47	damaging	0.13	damaging	3.60	23.20	deleterious	0.29	0.45	0.45	neutral	0.94	disease	0.73	disease	0.85	disease	7	1	deleterious	0.26	neutral	1	deleterious	0.86	deleterious	-3.55	low_impact	0.22	medium_impact	1.76	medium_impact	0.70	0.85	12.39	14.86	0.48	N	0.80	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14468	14468	T	G	MI.23756	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	206	69	Y	S	tAt/tCt	2.48	1	0	probably_damaging	1	neutral	0.4	neutral	1.65	deleterious	-6.99	deleterious	-8.97	high_impact	3.66	0.41	damaging	0.06	damaging	3.88	23.50	deleterious	0.2	0.45	0.81	disease	0.95	disease	0.78	disease	0.9	disease	8	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.11	medium_impact	1.93	medium_impact	0.52	0.8	12.39	14.86	0.71	P	0.96	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14468	14468	T	C	MI.23757	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	206	69	Y	C	tAt/tGt	2.48	1	0	probably_damaging	1	neutral	0.13	neutral	1.65	deleterious	-8.26	deleterious	-8.96	high_impact	4	0.4	damaging	0.04	damaging	3.25	22.80	deleterious	0.27	0.45	0.92	disease	0.96	disease	0.83	disease	0.91	disease	8	1	deleterious	0.07	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	-0.25	medium_impact	2.21	high_impact	0.39	0.8	12.39	14.86	0.73	P	1.00	NA	NA	0.86	.	.	.	.	.	.	COSM6716800	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14469	14469	A	G	MI.23758	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	205	69	Y	H	Tat/Cat	3.63	1	0	probably_damaging	1	neutral	0.33	neutral	1.66	deleterious	-6.32	deleterious	-4.98	medium_impact	3.46	0.57	damaging	0.05	damaging	3.58	23.20	deleterious	0.24	0.45	0.76	disease	0.93	disease	0.83	disease	0.91	disease	8	1	deleterious	0.17	neutral	1	deleterious	0.89	deleterious	-3.55	low_impact	0.04	medium_impact	1.76	medium_impact	0.58	0.8	12.39	14.86	0.45	N	0.98	NA	NA	0.85	.	.	.	.	.	.	COSM1138269	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14469	14469	A	C	MI.23759	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	205	69	Y	D	Tat/Gat	3.63	1	0	probably_damaging	1	neutral	0.12	neutral	1.65	deleterious	-8.57	deleterious	-9.96	high_impact	4	0.39	damaging	0.03	damaging	3.54	23.10	deleterious	0.13	0.4	0.87	disease	0.96	disease	0.85	disease	0.91	disease	8	1	deleterious	0.06	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.27	medium_impact	2.21	high_impact	0.43	0.8	12.39	14.86	0.72	P	0.97	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6135	6135	T	A	MI.2376	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	232	78	F	I	Ttt/Att	-15.37	0	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.52	deleterious	-4	high_impact	4.07	0.58	damaging	0.64	neutral	4.17	23.80	deleterious	0.29	0.55	0.44	neutral	0.91	disease	0.69	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.66	high_impact	0.61	0.9	1.56	8.79	0.44	N	0.88	polymorphism	0.68	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14469	14469	A	T	MI.23760	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	205	69	Y	N	Tat/Aat	3.63	1	0	probably_damaging	1	neutral	0.24	neutral	1.65	deleterious	-7.44	deleterious	-8.97	high_impact	4	0.31	damaging	0.05	damaging	3.52	23.10	deleterious	0.2	0.45	0.84	disease	0.95	disease	0.8	disease	0.91	disease	8	1	deleterious	0.12	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.07	medium_impact	2.21	high_impact	0.50	0.8	12.39	14.86	0.6	P	1.00	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14471	14471	C	G	MI.23761	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	203	68	G	A	gGa/gCa	-4.17	0	0	probably_damaging	1	neutral	0.6	neutral	2.42	neutral	1.74	deleterious	-5.6	low_impact	1.18	0.78	neutral	0.61	neutral	1.49	13.26	neutral	0.34	0.5	0.15	neutral	0.29	neutral	0.2	neutral	0.43	neutral	1	1	deleterious	0.3	neutral	-2	neutral	0.67	deleterious	-3.55	low_impact	0.3	medium_impact	-0.15	medium_impact	0.90	0.95	49.56	8.58	0.3	N	0.78	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14471	14471	C	A	MI.23762	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	203	68	G	V	gGa/gTa	-4.17	0	0	probably_damaging	1	neutral	0.56	neutral	2.43	neutral	1.87	deleterious	-8.63	medium_impact	2.15	0.65	neutral	0.27	damaging	4.20	23.90	deleterious	0.18	0.45	0.19	neutral	0.84	disease	0.38	neutral	0.6	disease	2	1	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	0.27	medium_impact	0.66	medium_impact	0.84	0.9	49.56	8.58	0.32	N	0.98	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14471	14471	C	T	MI.23763	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	203	68	G	E	gGa/gAa	-4.17	0	0	probably_damaging	1	neutral	0.26	neutral	2.29	neutral	-1.62	deleterious	-7.71	high_impact	3.62	0.63	neutral	0.06	damaging	4.01	23.60	deleterious	0.1	0.4	0.41	neutral	0.93	disease	0.7	disease	0.81	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	-0.05	medium_impact	1.89	medium_impact	0.84	0.9	49.56	8.58	0.35	N	1.00	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14472	14472	C	G	MI.23764	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	202	68	G	R	Gga/Cga	1.79	0.96	0	probably_damaging	1	neutral	0.32	neutral	2.3	neutral	-1.34	deleterious	-7.71	high_impact	3.62	0.62	neutral	0.04	damaging	4.09	23.70	deleterious	0.09	0.35	0.46	neutral	0.95	disease	0.72	disease	0.89	disease	8	1	deleterious	0.16	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.03	medium_impact	1.89	medium_impact	0.74	0.85	49.56	8.58	0.46	N	1.00	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14472	14472	C	A	MI.23765	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	202	68	G	W	Gga/Tga	1.79	0.96	0	probably_damaging	1	neutral	0.17	neutral	2.29	neutral	-2.61	deleterious	-7.78	high_impact	3.62	0.63	neutral	0.06	damaging	4.75	24.70	deleterious	0.11	0.4	0.79	disease	0.94	disease	0.66	disease	0.85	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.18	medium_impact	1.89	medium_impact	0.63	0.8	49.56	8.58	0.45	N	1.00	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14473	14473	A	C	MI.23766	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	201	67	F	L	ttT/ttG	5.23	1	0	probably_damaging	1	neutral	0.18	neutral	1.55	deleterious	-3.86	deleterious	-5.98	high_impact	4.01	0.51	damaging	0.03	damaging	3.99	23.60	deleterious	0.19	0.45	0.54	disease	0.95	disease	0.72	disease	0.86	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	-0.16	medium_impact	2.22	high_impact	0.70	0.85	13.27	10.97	0.59	P	0.90	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14473	14473	A	T	MI.23767	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	201	67	F	L	ttT/ttA	5.23	1	0	probably_damaging	1	neutral	0.18	neutral	1.55	deleterious	-3.86	deleterious	-5.98	high_impact	4.01	0.51	damaging	0.03	damaging	4.12	23.80	deleterious	0.19	0.45	0.54	disease	0.95	disease	0.72	disease	0.86	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	-0.16	medium_impact	2.22	high_impact	0.70	0.85	13.27	10.97	0.63	P	0.90	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14474	14474	A	T	MI.23768	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	200	67	F	Y	tTt/tAt	4.54	1	0	probably_damaging	1	neutral	0.4	neutral	1.45	neutral	-2.53	deleterious	-2.99	high_impact	4.01	0.51	damaging	0.04	damaging	3.85	23.40	deleterious	0.14	0.4	0.48	neutral	0.94	disease	0.74	disease	0.88	disease	8	1	deleterious	0.2	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.11	medium_impact	2.22	high_impact	0.65	0.8	13.27	10.97	0.64	P	0.88	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14474	14474	A	C	MI.23769	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	200	67	F	C	tTt/tGt	4.54	1	0	probably_damaging	1	neutral	0.08	neutral	1.41	deleterious	-7.38	deleterious	-7.98	high_impact	4.01	0.53	damaging	0.03	damaging	3.65	23.20	deleterious	0.13	0.4	0.91	disease	0.96	disease	0.77	disease	0.89	disease	8	1	deleterious	0.04	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.38	medium_impact	2.22	high_impact	0.39	0.8	13.27	10.97	0.62	P	0.98	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6135	6135	T	G	MI.2377	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	232	78	F	V	Ttt/Gtt	-15.37	0	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.52	deleterious	-4.67	high_impact	4.47	0.54	damaging	0.5	neutral	3.94	23.50	deleterious	0.32	0.55	0.51	disease	0.92	disease	0.73	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.03	high_impact	0.56	0.9	1.56	8.79	0.53	N	0.84	polymorphism	0.5	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14474	14474	A	G	MI.23770	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	200	67	F	S	tTt/tCt	4.54	1	0	probably_damaging	1	neutral	0.1	neutral	1.43	deleterious	-5.81	deleterious	-7.98	high_impact	4.01	0.55	damaging	0.04	damaging	4.27	23.90	deleterious	0.09	0.35	0.81	disease	0.96	disease	0.73	disease	0.87	disease	7	1	deleterious	0.05	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.32	medium_impact	2.22	high_impact	0.53	0.8	13.27	10.97	0.58	P	0.97	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14475	14475	A	T	MI.23771	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	199	67	F	I	Ttt/Att	6.61	1	0	probably_damaging	1	neutral	0.35	neutral	1.54	deleterious	-4.97	deleterious	-5.98	high_impact	4.01	0.52	damaging	0.04	damaging	3.89	23.50	deleterious	0.15	0.4	0.7	disease	0.96	disease	0.75	disease	0.88	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.06	medium_impact	2.22	high_impact	0.59	0.8	13.27	10.97	0.63	P	0.92	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14475	14475	A	C	MI.23772	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	199	67	F	V	Ttt/Gtt	6.61	1	0	probably_damaging	1	neutral	0.22	neutral	1.52	deleterious	-4.93	deleterious	-6.98	high_impact	3.66	0.47	damaging	0.03	damaging	3.60	23.20	deleterious	0.13	0.4	0.71	disease	0.97	disease	0.75	disease	0.89	disease	8	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.1	medium_impact	1.93	medium_impact	0.63	0.8	13.27	10.97	0.65	P	0.95	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14475	14475	A	G	MI.23773	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	199	67	F	L	Ttt/Ctt	6.61	1	0	probably_damaging	1	neutral	0.18	neutral	1.55	deleterious	-3.86	deleterious	-5.98	high_impact	4.01	0.51	damaging	0.03	damaging	4.04	23.70	deleterious	0.19	0.45	0.54	disease	0.95	disease	0.72	disease	0.86	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	-0.16	medium_impact	2.22	high_impact	0.70	0.85	13.27	10.97	0.61	P	0.90	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14477	14477	A	C	MI.23774	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	197	66	V	G	gTc/gGc	-6.47	0	0	probably_damaging	1	neutral	0.05	neutral	2.13	deleterious	-5.14	deleterious	-6.98	high_impact	4	0.5	damaging	0.06	damaging	3.36	22.90	deleterious	0.14	0.4	0.78	disease	0.93	disease	0.73	disease	0.83	disease	7	1	deleterious	0.03	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.5	medium_impact	2.21	high_impact	0.64	0.8	18.14	13.71	0.3	N	0.83	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14477	14477	A	G	MI.23775	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	197	66	V	A	gTc/gCc	-6.47	0	0	probably_damaging	1	neutral	0.08	neutral	2.15	neutral	-2.75	deleterious	-3.99	high_impact	3.66	0.53	damaging	0.08	damaging	3.50	23.10	deleterious	0.3	0.45	0.59	disease	0.84	disease	0.71	disease	0.78	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.80	deleterious	-3.55	low_impact	-0.38	medium_impact	1.93	medium_impact	0.60	0.8	18.14	13.71	0.28	N	0.52	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14477	14477	A	T	MI.23776	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	197	66	V	D	gTc/gAc	-6.47	0	0	probably_damaging	1	deleterious	0.01	neutral	2.12	deleterious	-6.17	deleterious	-6.97	high_impact	4	0.57	damaging	0.04	damaging	3.90	23.50	deleterious	0.1	0.4	0.87	disease	0.96	disease	0.8	disease	0.91	disease	8	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.55	low_impact	-0.9	medium_impact	2.21	high_impact	0.71	0.85	18.14	13.71	0.33	N	0.94	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14478	14478	C	T	MI.23777	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	196	66	V	I	Gtc/Atc	5.46	0.99	0	probably_damaging	1	neutral	0.31	neutral	2.29	neutral	-0.29	neutral	-1	medium_impact	3.31	0.64	neutral	0.09	damaging	3.86	23.50	deleterious	0.42	0.5	0.34	neutral	0.81	disease	0.66	disease	0.58	disease	2	1	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	0.01	medium_impact	1.63	medium_impact	0.88	0.9	18.14	13.71	0.47	N	0.46	NA	NA	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14478	14478	C	A	MI.23778	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	196	66	V	F	Gtc/Ttc	5.46	0.99	0	probably_damaging	1	neutral	0.42	neutral	2.19	neutral	-1.57	deleterious	-4.99	high_impact	4	0.58	damaging	0.03	damaging	4.15	23.80	deleterious	0.16	0.45	0.74	disease	0.96	disease	0.76	disease	0.88	disease	8	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0.13	medium_impact	2.21	high_impact	0.77	0.85	18.14	13.71	0.54	P	0.93	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14478	14478	C	G	MI.23779	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	196	66	V	L	Gtc/Ctc	5.46	0.99	0	probably_damaging	1	neutral	0.42	neutral	3.21	neutral	2.91	deleterious	-2.99	high_impact	4	0.49	damaging	0.04	damaging	3.69	23.30	deleterious	0.39	0.5	0.45	neutral	0.92	disease	0.7	disease	0.79	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.55	low_impact	0.13	medium_impact	2.21	high_impact	0.80	0.85	18.14	13.71	0.59	P	0.79	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6135	6135	T	C	MI.2378	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	232	78	F	L	Ttt/Ctt	-15.37	0	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-1.32	deleterious	-4	high_impact	3.64	0.54	damaging	0.61	neutral	3.61	23.20	deleterious	0.42	0.55	0.29	neutral	0.82	disease	0.67	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.26	high_impact	0.57	0.9	1.56	8.79	0.41	N	0.83	polymorphism	0.66	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14480	14480	A	T	MI.23780	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	194	65	V	D	gTt/gAt	-10.37	0	0	probably_damaging	0.98	deleterious	0.01	neutral	1.68	deleterious	-8.11	deleterious	-6.97	high_impact	3.91	0.51	damaging	0.38	neutral	4.53	24.30	deleterious	0.1	0.4	0.87	disease	0.95	disease	0.77	disease	0.9	disease	8	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-2.35	low_impact	-0.9	medium_impact	2.14	high_impact	0.63	0.8	49.12	8.59	0.44	N	0.94	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14480	14480	A	G	MI.23781	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	194	65	V	A	gTt/gCt	-10.37	0	0	possibly_damaging	0.82	neutral	0.1	neutral	1.73	deleterious	-4.08	deleterious	-3.99	high_impact	3.91	0.56	damaging	0.46	neutral	3.87	23.50	deleterious	0.22	0.45	0.59	disease	0.83	disease	0.65	disease	0.71	disease	4	0.94	neutral	0.14	neutral	1	deleterious	0.74	deleterious	-1.4	low_impact	-0.32	medium_impact	2.14	high_impact	0.52	0.8	49.12	8.59	0.44	N	0.52	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14480	14480	A	C	MI.23782	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	194	65	V	G	gTt/gGt	-10.37	0	0	probably_damaging	0.98	neutral	0.1	neutral	1.68	deleterious	-7.25	deleterious	-6.97	high_impact	3.91	0.52	damaging	0.43	neutral	3.84	23.40	deleterious	0.14	0.4	0.78	disease	0.93	disease	0.67	disease	0.75	disease	5	0.99	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	-0.32	medium_impact	2.14	high_impact	0.57	0.8	49.12	8.59	0.39	N	0.83	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14481	14481	C	G	MI.23783	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	193	65	V	L	Gtt/Ctt	8.44	1	0	possibly_damaging	0.62	neutral	0.56	neutral	1.76	deleterious	-3.36	deleterious	-2.99	high_impact	3.91	0.53	damaging	0.43	neutral	2.12	17.00	deleterious	0.2	0.45	0.45	neutral	0.91	disease	0.64	disease	0.74	disease	5	0.57	neutral	0.47	deleterious	1	deleterious	0.65	deleterious	-0.99	medium_impact	0.27	medium_impact	2.14	high_impact	0.70	0.85	49.12	8.59	0.66	P	0.79	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14481	14481	C	T	MI.23784	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	193	65	V	I	Gtt/Att	8.44	1	0	benign	0.18	neutral	0.26	neutral	2.4	neutral	0.19	neutral	-1	medium_impact	2.81	0.75	neutral	0.51	neutral	1.91	15.67	deleterious	0.3	0.45	0.34	neutral	0.83	disease	0.6	disease	0.71	disease	4	0.69	neutral	0.54	deleterious	-3	neutral	0.29	neutral	-0.19	medium_impact	-0.05	medium_impact	1.21	medium_impact	0.87	0.9	49.12	8.59	0.66	P	0.46	NA	NA	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14481	14481	C	A	MI.23785	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	193	65	V	F	Gtt/Ttt	8.44	1	0	probably_damaging	0.96	neutral	0.52	neutral	1.69	deleterious	-5.95	deleterious	-4.98	high_impact	3.91	0.52	damaging	0.35	neutral	4.26	23.90	deleterious	0.13	0.4	0.74	disease	0.96	disease	0.71	disease	0.84	disease	7	0.96	neutral	0.28	neutral	2	deleterious	0.85	deleterious	-2.06	low_impact	0.23	medium_impact	2.14	high_impact	0.68	0.85	49.12	8.59	0.65	P	0.93	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14482	14482	C	A	MI.23786	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	192	64	M	I	atG/atT	3.4	0.99	0	probably_damaging	0.99	neutral	0.31	neutral	2.16	neutral	-1.75	neutral	-1.3	medium_impact	3.06	0.19	damaging	0.25	damaging	2.63	20.40	deleterious	0.39	0.5	0.19	neutral	0.9	disease	0.61	disease	0.8	disease	6	0.99	deleterious	0.16	neutral	1	deleterious	0.79	deleterious	-2.63	low_impact	0.01	medium_impact	1.42	medium_impact	0.78	0.85	18.14	20.1	0.96	P	0.87	NA	NA	0.33	rs199476108	Pathogenic	Leber's_optic_atrophy	24732	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	C14482A	LHON	+	+	Cfrm	11	P	P	P	damaging
chrM	14482	14482	C	G	MI.23787	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	192	64	M	I	atG/atC	3.4	0.99	0	probably_damaging	0.99	neutral	0.31	neutral	2.16	neutral	-1.75	neutral	-1.3	medium_impact	3.06	0.19	damaging	0.25	damaging	2.13	17.02	deleterious	0.39	0.5	0.19	neutral	0.9	disease	0.61	disease	0.8	disease	6	0.99	deleterious	0.16	neutral	1	deleterious	0.79	deleterious	-2.63	low_impact	0.01	medium_impact	1.42	medium_impact	0.78	0.85	18.14	20.1	0.96	P	0.87	NA	NA	0.33	rs199476108	Pathogenic	Leber's_optic_atrophy	76421	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	C14482G	LHON	+	+	Cfrm	5	P	P	P	damaging
chrM	14483	14483	A	T	MI.23788	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	191	64	M	K	aTg/aAg	-2.8	0	0	probably_damaging	0.99	neutral	0.05	neutral	2.11	deleterious	-3.82	deleterious	-4.64	medium_impact	3.06	0.42	damaging	0.34	neutral	3.56	23.10	deleterious	0.15	0.4	0.67	disease	0.96	disease	0.68	disease	0.87	disease	7	1	deleterious	0.03	neutral	1	deleterious	0.89	deleterious	-2.63	low_impact	-0.5	medium_impact	1.42	medium_impact	0.48	0.8	18.14	20.1	0.48	N	0.93	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14483	14483	A	G	MI.23789	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	191	64	M	T	aTg/aCg	-2.8	0	0	probably_damaging	0.99	deleterious	0.03	neutral	2.14	neutral	-2.27	deleterious	-3.96	medium_impact	3.06	0.41	damaging	0.45	neutral	2.77	21.20	deleterious	0.3	0.45	0.5	disease	0.87	disease	0.62	disease	0.8	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-2.63	low_impact	-0.63	medium_impact	1.42	medium_impact	0.39	0.8	18.14	20.1	0.53	P	0.78	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6136	6136	T	G	MI.2379	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	233	78	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-5.75	deleterious	-5.34	high_impact	5.17	0.59	damaging	0.5	neutral	3.95	23.60	deleterious	0.26	0.55	0.85	disease	0.88	disease	0.75	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.37	0.9	1.56	8.79	0.67	P	0.91	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14484	14484	T	C	MI.23790	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	190	64	M	V	Atg/Gtg	5.46	0.51	0.04	probably_damaging	0.99	neutral	0.49	neutral	2.26	neutral	-0.49	neutral	-1.97	medium_impact	3.06	0.24	damaging	0.47	neutral	0.89	10.02	neutral	0.39	0.5	0.23	neutral	0.92	disease	0.61	disease	0.81	disease	6	0.99	deleterious	0.25	neutral	1	deleterious	0.80	deleterious	-2.63	low_impact	0.2	medium_impact	1.42	medium_impact	0.58	0.8	18.14	20.1	0.95	P	0.71	NA	NA	0.39	rs199476104	Pathogenic	Leber's_optic_atrophy|Leigh_syndrome|not_specified|not_provided	24727	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:CN169374|MedGen:CN517202	.	.	CPD	0.15	T14484C	LHON	+	+	Cfrm	153	P	P	P	neutral
chrM	14484	14484	T	A	MI.23791	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	190	64	M	L	Atg/Ttg	5.46	0.51	0.04	probably_damaging	0.98	neutral	1	neutral	2.42	neutral	0.6	neutral	0.36	neutral_impact	0	0.84	neutral	0.98	neutral	-0.99	0.02	neutral	0.33	0.5	0.17	neutral	0.54	disease	0.38	neutral	0.42	neutral	2	0.98	neutral	0.51	deleterious	-2	neutral	0.66	deleterious	-2.35	low_impact	1.87	high_impact	-1.14	low_impact	0.64	0.8	18.14	20.1	0.42	N	0.25	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14484	14484	T	G	MI.23792	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	190	64	M	L	Atg/Ctg	5.46	0.51	0.04	probably_damaging	0.98	neutral	1	neutral	2.42	neutral	0.6	neutral	0.36	neutral_impact	0	0.84	neutral	0.98	neutral	-1.10	0.01	neutral	0.33	0.5	0.17	neutral	0.54	disease	0.38	neutral	0.42	neutral	2	0.98	neutral	0.51	deleterious	-2	neutral	0.66	deleterious	-2.35	low_impact	1.87	high_impact	-1.14	low_impact	0.64	0.8	18.14	20.1	0.41	N	0.25	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14485	14485	C	A	MI.23793	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	189	63	M	I	atG/atT	-2.11	0	0	probably_damaging	0.99	neutral	0.31	neutral	2.72	deleterious	-3.54	deleterious	-3.99	high_impact	4.01	0.44	damaging	0.02	damaging	2.31	18.22	deleterious	0.26	0.45	0.5	disease	0.96	disease	0.78	disease	0.88	disease	8	0.99	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-2.63	low_impact	0.01	medium_impact	2.22	high_impact	0.61	0.8	18.58	14.48	0.5	N	0.91	NA	NA	0.84	rs386829213	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14485	14485	C	G	MI.23794	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	189	63	M	I	atG/atC	-2.11	0	0	probably_damaging	0.99	neutral	0.31	neutral	2.72	deleterious	-3.54	deleterious	-3.99	high_impact	4.01	0.44	damaging	0.02	damaging	1.78	14.88	neutral	0.26	0.45	0.5	disease	0.96	disease	0.78	disease	0.88	disease	8	0.99	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-2.63	low_impact	0.01	medium_impact	2.22	high_impact	0.61	0.8	18.58	14.48	0.49	N	0.91	NA	NA	0.84	rs386829213	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14486	14486	A	G	MI.23795	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	188	63	M	T	aTg/aCg	-3.49	0	0	probably_damaging	0.99	neutral	0.07	neutral	2.18	deleterious	-5.03	deleterious	-5.98	high_impact	4.01	0.44	damaging	0.05	damaging	1.50	13.29	neutral	0.2	0.45	0.72	disease	0.96	disease	0.78	disease	0.88	disease	8	1	deleterious	0.04	neutral	2	deleterious	0.91	deleterious	-2.63	low_impact	-0.42	medium_impact	2.22	high_impact	0.36	0.8	18.58	14.48	0.52	P	0.96	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14486	14486	A	T	MI.23796	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	188	63	M	K	aTg/aAg	-3.49	0	0	probably_damaging	0.99	deleterious	0.02	neutral	2.13	deleterious	-5.38	deleterious	-5.98	high_impact	4.01	0.52	damaging	0.02	damaging	3.33	22.90	deleterious	0.14	0.4	0.77	disease	0.98	disease	0.83	disease	0.9	disease	8	1	deleterious	0.02	neutral	6	deleterious	0.91	deleterious	-2.63	low_impact	-0.73	medium_impact	2.22	high_impact	0.51	0.8	18.58	14.48	0.35	N	0.98	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14487	14487	T	A	MI.23797	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	187	63	M	L	Atg/Ttg	8.21	1	0	probably_damaging	0.98	neutral	0.57	neutral	2.36	neutral	-2.47	deleterious	-2.99	high_impact	4.01	0.44	damaging	0.06	damaging	1.79	14.94	neutral	0.19	0.45	0.34	neutral	0.95	disease	0.75	disease	0.87	disease	7	0.98	neutral	0.3	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	0.27	medium_impact	2.22	high_impact	0.45	0.8	18.58	14.48	0.73	P	0.97	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14487	14487	T	G	MI.23798	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	187	63	M	L	Atg/Ctg	8.21	1	0	probably_damaging	0.98	neutral	0.57	neutral	2.36	neutral	-2.47	deleterious	-2.99	high_impact	4.01	0.44	damaging	0.06	damaging	1.68	14.29	neutral	0.19	0.45	0.34	neutral	0.95	disease	0.75	disease	0.87	disease	7	0.98	neutral	0.3	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	0.27	medium_impact	2.22	high_impact	0.45	0.8	18.58	14.48	0.66	P	0.97	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14487	14487	T	C	MI.23799	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	187	63	M	V	Atg/Gtg	8.21	1	0	probably_damaging	0.99	neutral	0.42	neutral	2.39	deleterious	-3.62	deleterious	-3.98	high_impact	4.01	0.28	damaging	0.04	damaging	0.66	8.55	deleterious	0.25	0.45	0.52	disease	0.96	disease	0.79	disease	0.88	disease	8	0.99	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-2.63	low_impact	0.13	medium_impact	2.22	high_impact	0.48	0.8	18.58	14.48	0.9	P	0.93	NA	NA	0.85	rs199476109	Pathogenic	Leigh_syndrome|Leigh_syndrome_due_to_mitochondrial_complex_I_deficiency|Striatal_necrosis,_bilateral,_with_dystonia	24733	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838951|MedGen:C1838954	.	.	.	.	T14487C	Dystonia / Leigh Disease / Ataxia / Ptosis / Epilepsy	-	+	Cfrm	22	P	P	P	damaging
chrM	8638	8638	A	C	MI.238	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	112	38	I	L	Atc/Ctc	-0.1	0	0	probably_damaging	0.93	neutral	0.87	neutral	4.34	neutral	-0.55	neutral	-0.86	neutral_impact	0.04	0.94	neutral	0.94	neutral	1.01	10.73	neutral	0.47	0.65	0.47	neutral	0.16	neutral	0.17	neutral	0.27	neutral	5	0.92	neutral	0.47	deleterious	-2	neutral	0.61	deleterious	-1.82	low_impact	0.76	medium_impact	-1.06	low_impact	0.49	0.9	15.49	18.25	0.33	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6136	6136	T	C	MI.2380	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	233	78	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-4.35	deleterious	-5.34	high_impact	4.82	0.56	damaging	0.62	neutral	2.49	19.40	deleterious	0.27	0.55	0.34	neutral	0.86	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.41	0.9	1.56	8.79	0.62	P	0.84	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14489	14489	C	T	MI.23800	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	185	62	G	E	gGa/gAa	-20	0	0	probably_damaging	1	neutral	0.27	neutral	1.57	deleterious	-7.13	deleterious	-7.98	high_impact	4.01	0.5	damaging	0.02	damaging	4.10	23.70	deleterious	0.18	0.45	0.84	disease	0.96	disease	0.85	disease	0.91	disease	8	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.03	medium_impact	2.22	high_impact	0.60	0.8	18.14	14.91	0.39	N	1.00	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14489	14489	C	G	MI.23801	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	185	62	G	A	gGa/gCa	-20	0	0	probably_damaging	1	neutral	0.51	neutral	2.41	deleterious	-6.07	deleterious	-5.99	high_impact	3.66	0.51	damaging	0.05	damaging	3.32	22.90	deleterious	0.16	0.45	0.71	disease	0.89	disease	0.78	disease	0.82	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.22	medium_impact	1.93	medium_impact	0.65	0.8	18.14	14.91	0.32	N	0.78	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14489	14489	C	A	MI.23802	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	185	62	G	V	gGa/gTa	-20	0	0	probably_damaging	1	neutral	0.57	neutral	1.58	deleterious	-7.52	deleterious	-8.98	high_impact	4.01	0.42	damaging	0.02	damaging	4.12	23.80	deleterious	0.13	0.4	0.87	disease	0.97	disease	0.82	disease	0.92	disease	8	1	deleterious	0.29	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	0.27	medium_impact	2.22	high_impact	0.59	0.8	18.14	14.91	0.44	N	0.98	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14490	14490	C	G	MI.23803	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	184	62	G	R	Gga/Cga	2.71	0.97	0	probably_damaging	1	neutral	0.35	neutral	1.56	deleterious	-7.73	deleterious	-7.98	high_impact	4.01	0.48	damaging	0.01	damaging	4.14	23.80	deleterious	0.17	0.45	0.88	disease	0.97	disease	0.86	disease	0.92	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.06	medium_impact	2.22	high_impact	0.72	0.85	18.14	14.91	0.57	P	1.00	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14490	14490	C	A	MI.23804	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	184	62	G	W	Gga/Tga	2.71	0.97	0	probably_damaging	1	neutral	0.18	neutral	1.55	deleterious	-10.14	deleterious	-7.97	high_impact	4.01	0.49	damaging	0.01	damaging	4.77	24.70	deleterious	0.16	0.45	0.97	disease	0.96	disease	0.82	disease	0.91	disease	8	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.16	medium_impact	2.22	high_impact	0.47	0.8	18.14	14.91	0.52	P	1.00	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14492	14492	C	G	MI.23805	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	182	61	G	A	gGg/gCg	-8.76	0	0	probably_damaging	1	neutral	0.28	neutral	0.4	deleterious	-6.55	deleterious	-5.99	high_impact	4.01	0.5	damaging	0.04	damaging	3.32	22.90	deleterious	0.17	0.45	0.71	disease	0.91	disease	0.77	disease	0.82	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.02	medium_impact	2.22	high_impact	0.64	0.8	48.67	8.33	0.37	N	0.78	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14492	14492	C	A	MI.23806	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	182	61	G	V	gGg/gTg	-8.76	0	0	probably_damaging	1	neutral	0.62	neutral	0.38	deleterious	-7.02	deleterious	-8.98	high_impact	4.01	0.42	damaging	0.02	damaging	4.18	23.80	deleterious	0.14	0.4	0.87	disease	0.97	disease	0.8	disease	0.91	disease	8	1	deleterious	0.31	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.32	medium_impact	2.22	high_impact	0.61	0.8	48.67	8.33	0.41	N	0.98	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14492	14492	C	T	MI.23807	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	182	61	G	E	gGg/gAg	-8.76	0	0	probably_damaging	1	neutral	0.13	neutral	0.36	deleterious	-9.67	deleterious	-7.99	high_impact	4.01	0.5	damaging	0.02	damaging	4.13	23.80	deleterious	0.16	0.45	0.84	disease	0.96	disease	0.84	disease	0.92	disease	8	1	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.25	medium_impact	2.22	high_impact	0.62	0.8	48.67	8.33	0.4	N	1.00	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14493	14493	C	G	MI.23808	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	181	61	G	R	Ggg/Cgg	4.31	0.99	0	probably_damaging	1	neutral	0.17	neutral	0.36	deleterious	-9.8	deleterious	-7.99	high_impact	4.01	0.48	damaging	0.01	damaging	4.09	23.70	deleterious	0.15	0.4	0.88	disease	0.97	disease	0.85	disease	0.91	disease	8	1	deleterious	0.09	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	-0.18	medium_impact	2.22	high_impact	0.70	0.85	48.67	8.33	0.61	P	1.00	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14493	14493	C	A	MI.23809	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	181	61	G	W	Ggg/Tgg	4.31	0.99	0	probably_damaging	1	neutral	0.1	neutral	0.35	deleterious	-12.56	deleterious	-7.99	high_impact	4.01	0.49	damaging	0.01	damaging	4.70	24.60	deleterious	0.14	0.4	0.97	disease	0.97	disease	0.82	disease	0.9	disease	8	1	deleterious	0.05	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.32	medium_impact	2.22	high_impact	0.41	0.8	48.67	8.33	0.5	P	1.00	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6136	6136	T	A	MI.2381	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	233	78	F	Y	tTt/tAt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.54	neutral	-2	high_impact	4.01	0.62	neutral	0.48	neutral	3.86	23.50	deleterious	0.3	0.55	0.69	disease	0.81	disease	0.69	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.6	high_impact	0.65	0.9	1.56	8.79	0.59	P	0.59	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14494	14494	T	A	MI.23810	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	180	60	L	F	ttA/ttT	5.46	0.99	0	probably_damaging	1	neutral	0.52	neutral	2.14	deleterious	-4.53	deleterious	-3.99	high_impact	3.66	0.66	neutral	0.3	neutral	3.80	23.40	deleterious	0.32	0.5	0.55	disease	0.88	disease	0.75	disease	0.81	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	0.23	medium_impact	1.93	medium_impact	0.68	0.85	26.99	19.59	0.61	P	0.95	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14494	14494	T	G	MI.23811	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	180	60	L	F	ttA/ttC	5.46	0.99	0	probably_damaging	1	neutral	0.52	neutral	2.14	deleterious	-4.53	deleterious	-3.99	high_impact	3.66	0.66	neutral	0.3	neutral	3.66	23.20	deleterious	0.32	0.5	0.55	disease	0.88	disease	0.75	disease	0.81	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	0.23	medium_impact	1.93	medium_impact	0.68	0.85	26.99	19.59	0.61	P	0.95	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14495	14495	A	C	MI.23812	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	179	60	L	W	tTa/tGa	-4.86	0	0	probably_damaging	1	neutral	0.12	neutral	2.1	deleterious	-7.73	deleterious	-5.99	high_impact	4	0.5	damaging	0.25	damaging	3.29	22.80	deleterious	0.15	0.45	0.9	disease	0.91	disease	0.78	disease	0.88	disease	8	1	deleterious	0.06	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	-0.27	medium_impact	2.21	high_impact	0.68	0.85	26.99	19.59	0.42	N	0.98	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14495	14495	A	G	MI.23813	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	179	60	L	S	tTa/tCa	-4.86	0	0	probably_damaging	1	neutral	0.29	neutral	2.17	deleterious	-6.14	deleterious	-5.99	high_impact	3.66	0.23	damaging	0.17	damaging	3.77	23.40	deleterious	0.19	0.45	0.82	disease	0.91	disease	0.75	disease	0.84	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.01	medium_impact	1.93	medium_impact	0.64	0.8	26.99	19.59	0.87	P	0.97	NA	NA	0.84	rs199476106	Pathogenic	Leber's_optic_atrophy	24730	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	A14495G	LHON	-	+	Cfrm	7	P	P	P	damaging
chrM	14496	14496	A	T	MI.23814	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	178	60	L	M	Tta/Ata	8.44	1	0	probably_damaging	1	neutral	0.19	neutral	2.14	deleterious	-3.75	neutral	-2	high_impact	3.66	0.58	damaging	0.42	neutral	3.26	22.80	deleterious	0.25	0.45	0.33	neutral	0.84	disease	0.73	disease	0.78	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.75	deleterious	-3.55	low_impact	-0.14	medium_impact	1.93	medium_impact	0.72	0.85	26.99	19.59	0.65	P	0.87	NA	NA	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14496	14496	A	C	MI.23815	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	178	60	L	V	Tta/Gta	8.44	1	0	probably_damaging	1	neutral	0.4	neutral	2.69	deleterious	-3.35	deleterious	-2.99	high_impact	3.66	0.52	damaging	0.23	damaging	3.03	22.30	deleterious	0.36	0.5	0.44	neutral	0.89	disease	0.78	disease	0.8	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.82	deleterious	-3.55	low_impact	0.11	medium_impact	1.93	medium_impact	0.70	0.85	26.99	19.59	0.71	P	0.71	NA	NA	0.65	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14498	14498	T	C	MI.23816	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	176	59	Y	C	tAt/tGt	3.85	1	0	probably_damaging	1	neutral	0.11	neutral	1.32	deleterious	-7.64	deleterious	-8.85	high_impact	4.01	0.2	damaging	0.02	damaging	3.37	22.90	deleterious	0.32	0.5	0.92	disease	0.95	disease	0.84	disease	0.91	disease	8	1	deleterious	0.06	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.3	medium_impact	2.22	high_impact	0.33	0.8	24.34	15.68	0.86	P	1.00	NA	NA	0.85	rs869025186	Pathogenic	Leber's_optic_atrophy	76422	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	T14498C	LHON	+	+	Reported	4	P	P	P	damaging
chrM	14498	14498	T	G	MI.23817	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	176	59	Y	S	tAt/tCt	3.85	1	0	probably_damaging	1	neutral	0.25	neutral	1.33	deleterious	-5.96	deleterious	-8.85	high_impact	4.01	0.4	damaging	0.06	damaging	3.93	23.50	deleterious	0.24	0.45	0.81	disease	0.93	disease	0.79	disease	0.88	disease	8	1	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.06	medium_impact	2.22	high_impact	0.33	0.8	24.34	15.68	0.71	P	0.96	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14498	14498	T	A	MI.23818	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	176	59	Y	F	tAt/tTt	3.85	1	0	probably_damaging	1	neutral	0.51	neutral	1.45	neutral	-2.72	deleterious	-3.76	high_impact	3.66	0.53	damaging	0.06	damaging	3.75	23.30	deleterious	0.24	0.45	0.45	neutral	0.92	disease	0.79	disease	0.81	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	0.22	medium_impact	1.93	medium_impact	0.52	0.8	24.34	15.68	0.62	P	0.80	NA	NA	0.85	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14499	14499	A	G	MI.23819	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	175	59	Y	H	Tat/Cat	2.94	1	0	probably_damaging	1	neutral	0.32	neutral	1.32	deleterious	-5.4	deleterious	-4.96	high_impact	4.01	0.44	damaging	0.03	damaging	3.30	22.80	deleterious	0.25	0.45	0.76	disease	0.93	disease	0.86	disease	0.89	disease	8	1	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	0.03	medium_impact	2.22	high_impact	0.40	0.8	24.34	15.68	0.73	P	0.98	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6137	6137	T	A	MI.2382	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	234	78	F	L	ttT/ttA	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-1.32	deleterious	-4	high_impact	3.64	0.54	damaging	0.61	neutral	3.90	23.50	deleterious	0.42	0.55	0.29	neutral	0.82	disease	0.67	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.26	high_impact	0.57	0.9	1.56	8.79	0.56	P	0.83	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14499	14499	A	T	MI.23820	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	175	59	Y	N	Tat/Aat	2.94	1	0	probably_damaging	1	neutral	0.19	neutral	1.33	deleterious	-6.34	deleterious	-8.88	high_impact	4.01	0.31	damaging	0.05	damaging	3.33	22.90	deleterious	0.25	0.45	0.84	disease	0.93	disease	0.8	disease	0.88	disease	8	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	-0.14	medium_impact	2.22	high_impact	0.27	0.8	24.34	15.68	0.75	P	1.00	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14499	14499	A	C	MI.23821	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	175	59	Y	D	Tat/Gat	2.94	1	0	probably_damaging	1	neutral	0.12	neutral	1.31	deleterious	-7.13	deleterious	-9.85	high_impact	4.01	0.38	damaging	0.03	damaging	3.30	22.90	deleterious	0.16	0.45	0.87	disease	0.95	disease	0.85	disease	0.91	disease	8	1	deleterious	0.06	neutral	2	deleterious	0.87	deleterious	-3.55	low_impact	-0.27	medium_impact	2.22	high_impact	0.27	0.8	24.34	15.68	0.75	P	0.97	NA	NA	0.86	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14500	14500	A	T	MI.23822	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	174	58	I	M	atT/atA	5.46	1	0	possibly_damaging	0.79	neutral	0.18	neutral	1.95	deleterious	-3.13	deleterious	-2.68	medium_impact	3.44	0.6	damaging	0.41	neutral	2.93	22.00	deleterious	0.33	0.5	0.61	disease	0.86	disease	0.69	disease	0.76	disease	5	0.89	neutral	0.2	neutral	0	NA	0.70	deleterious	-1.32	low_impact	-0.16	medium_impact	1.74	medium_impact	0.77	0.85	40.71	8.78	0.65	P	0.77	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14500	14500	A	C	MI.23823	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	174	58	I	M	atT/atG	5.46	1	0	possibly_damaging	0.79	neutral	0.18	neutral	1.95	deleterious	-3.13	deleterious	-2.68	medium_impact	3.44	0.6	damaging	0.41	neutral	2.82	21.50	deleterious	0.33	0.5	0.61	disease	0.86	disease	0.69	disease	0.76	disease	5	0.89	neutral	0.2	neutral	0	NA	0.70	deleterious	-1.32	low_impact	-0.16	medium_impact	1.74	medium_impact	0.77	0.85	40.71	8.78	0.54	P	0.77	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14501	14501	A	C	MI.23824	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	173	58	I	S	aTt/aGt	-0.27	0.08	0.01	possibly_damaging	0.62	neutral	0.2	neutral	1.94	deleterious	-3.52	deleterious	-5.67	high_impact	3.78	0.47	damaging	0.4	neutral	3.38	22.90	deleterious	0.22	0.45	0.76	disease	0.93	disease	0.65	disease	0.78	disease	6	0.81	neutral	0.29	neutral	1	deleterious	0.72	deleterious	-0.99	medium_impact	-0.13	medium_impact	2.03	high_impact	0.51	0.8	40.71	8.78	0.48	N	0.97	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14501	14501	A	G	MI.23825	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	173	58	I	T	aTt/aCt	-0.27	0.08	0.01	possibly_damaging	0.46	neutral	0.07	neutral	1.93	deleterious	-3.92	deleterious	-4.35	high_impact	3.78	0.67	neutral	0.43	neutral	1.64	14.09	neutral	0.36	0.5	0.63	disease	0.9	disease	0.67	disease	0.76	disease	5	0.92	neutral	0.31	neutral	1	deleterious	0.55	deleterious	-0.73	medium_impact	-0.42	medium_impact	2.03	high_impact	0.62	0.8	40.71	8.78	0.46	N	0.91	NA	NA	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14501	14501	A	T	MI.23826	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	173	58	I	N	aTt/aAt	-0.27	0.08	0.01	possibly_damaging	0.88	deleterious	0.04	neutral	1.91	deleterious	-6.06	deleterious	-6.67	high_impact	3.78	0.54	damaging	0.37	neutral	3.69	23.30	deleterious	0.28	0.45	0.86	disease	0.93	disease	0.69	disease	0.81	disease	6	0.98	deleterious	0.08	neutral	5	deleterious	0.81	deleterious	-1.59	low_impact	-0.56	medium_impact	2.03	high_impact	0.55	0.8	40.71	8.78	0.4	N	0.99	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14502	14502	T	C	MI.23827	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	172	58	I	V	Att/Gtt	5.46	0.8	0.01	benign	0.02	neutral	0.45	neutral	2.75	neutral	1.24	neutral	-0.37	low_impact	1.23	0.97	neutral	0.92	neutral	-0.98	0.02	neutral	0.43	0.55	0.18	neutral	0.47	neutral	0.44	neutral	0.41	neutral	2	0.53	neutral	0.72	deleterious	-6	neutral	0.14	neutral	0.75	medium_impact	0.16	medium_impact	-0.11	medium_impact	0.66	0.8	40.71	8.78	0.46	N	0.08	NA	NA	0.22	rs201327354	.	.	.	.	.	.	.	.	T14502C	LHON	+	-	Reported - possibly synergistic	4	N	N	N	neutral
chrM	14502	14502	T	A	MI.23828	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	172	58	I	F	Att/Ttt	5.46	0.8	0.01	benign	0.03	neutral	0.34	neutral	1.92	deleterious	-4.67	deleterious	-3.99	high_impact	3.78	0.53	damaging	0.38	neutral	2.16	17.25	deleterious	0.32	0.5	0.66	disease	0.92	disease	0.69	disease	0.78	disease	6	0.64	neutral	0.66	deleterious	-2	neutral	0.31	neutral	0.59	medium_impact	0.05	medium_impact	2.03	high_impact	0.70	0.85	40.71	8.78	0.55	P	0.92	NA	NA	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14502	14502	T	G	MI.23829	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	172	58	I	L	Att/Ctt	5.46	0.8	0.01	benign	0.15	neutral	0.52	neutral	2.04	neutral	-1.67	neutral	-2	medium_impact	3.23	0.55	damaging	0.43	neutral	2.10	16.85	deleterious	0.3	0.45	0.32	neutral	0.89	disease	0.64	disease	0.74	disease	5	0.38	neutral	0.69	deleterious	-3	neutral	0.30	neutral	-0.11	medium_impact	0.23	medium_impact	1.57	medium_impact	0.66	0.8	40.71	8.78	0.53	N	0.65	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6137	6137	T	G	MI.2383	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	234	78	F	L	ttT/ttG	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-1.32	deleterious	-4	high_impact	3.64	0.54	damaging	0.61	neutral	3.81	23.40	deleterious	0.42	0.55	0.29	neutral	0.82	disease	0.67	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.26	high_impact	0.57	0.9	1.56	8.79	0.56	P	0.83	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14503	14503	T	G	MI.23830	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	171	57	L	F	ttA/ttC	0.18	0.02	0	probably_damaging	0.92	neutral	0.39	neutral	1.71	deleterious	-4.16	deleterious	-3.99	high_impact	3.63	0.42	damaging	0.24	damaging	3.62	23.20	deleterious	0.27	0.45	0.55	disease	0.89	disease	0.72	disease	0.79	disease	6	0.93	neutral	0.24	neutral	2	deleterious	0.81	deleterious	-1.77	low_impact	0.1	medium_impact	1.9	medium_impact	0.62	0.8	14.16	15.31	0.49	N	0.95	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14503	14503	T	A	MI.23831	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	171	57	L	F	ttA/ttT	0.18	0.02	0	probably_damaging	0.92	neutral	0.39	neutral	1.71	deleterious	-4.16	deleterious	-3.99	high_impact	3.63	0.42	damaging	0.24	damaging	3.86	23.50	deleterious	0.27	0.45	0.55	disease	0.89	disease	0.72	disease	0.79	disease	6	0.93	neutral	0.24	neutral	2	deleterious	0.81	deleterious	-1.77	low_impact	0.1	medium_impact	1.9	medium_impact	0.62	0.8	14.16	15.31	0.48	N	0.95	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14504	14504	A	G	MI.23832	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	170	57	L	S	tTa/tCa	-2.57	0	0	probably_damaging	0.98	neutral	0.07	neutral	1.67	deleterious	-6.23	deleterious	-5.98	high_impact	3.98	0.38	damaging	0.28	damaging	3.75	23.30	deleterious	0.16	0.45	0.82	disease	0.92	disease	0.74	disease	0.83	disease	7	0.99	deleterious	0.05	neutral	2	deleterious	0.87	deleterious	-2.35	low_impact	-0.42	medium_impact	2.19	high_impact	0.64	0.8	14.16	15.31	0.57	P	0.97	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14504	14504	A	C	MI.23833	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	170	57	L	W	tTa/tGa	-2.57	0	0	benign	0.34	deleterious	0.01	neutral	1.66	deleterious	-8.05	deleterious	-5.98	high_impact	3.98	0.35	damaging	0.24	damaging	1.49	13.24	neutral	0.12	0.4	0.9	disease	0.92	disease	0.76	disease	0.86	disease	7	0.99	deleterious	0.34	neutral	2	deleterious	0.47	deleterious	-0.53	medium_impact	-0.9	medium_impact	2.19	high_impact	0.59	0.8	14.16	15.31	0.58	P	0.98	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14505	14505	A	C	MI.23834	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	169	57	L	V	Tta/Gta	3.63	1	0	probably_damaging	0.92	neutral	0.21	neutral	1.79	neutral	-2.59	deleterious	-2.99	high_impact	3.98	0.26	damaging	0.23	damaging	2.96	22.10	deleterious	0.28	0.45	0.44	neutral	0.91	disease	0.73	disease	0.8	disease	6	0.95	neutral	0.15	neutral	2	deleterious	0.80	deleterious	-1.77	low_impact	-0.11	medium_impact	2.19	high_impact	0.73	0.85	14.16	15.31	0.92	P	0.71	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14505	14505	A	T	MI.23835	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	169	57	L	M	Tta/Ata	3.63	1	0	probably_damaging	0.98	neutral	0.27	neutral	1.77	neutral	-2.9	neutral	-2	medium_impact	2.6	0.8	neutral	0.58	neutral	3.24	22.80	deleterious	0.23	0.45	0.33	neutral	0.7	disease	0.7	disease	0.56	disease	1	0.99	deleterious	0.15	neutral	1	deleterious	0.75	deleterious	-2.35	low_impact	-0.03	medium_impact	1.04	medium_impact	0.61	0.8	14.16	15.31	0.5	N	0.87	NA	NA	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14506	14506	A	C	MI.23836	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	168	56	F	L	ttT/ttG	2.25	1	0	probably_damaging	1	neutral	0.83	neutral	2.37	neutral	-1.74	deleterious	-5.99	medium_impact	2.2	0.7	neutral	0.16	damaging	1.87	15.38	deleterious	0.3	0.45	0.21	neutral	0.89	disease	0.52	disease	0.57	disease	1	1	deleterious	0.42	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	0.59	medium_impact	0.7	medium_impact	0.68	0.85	50	8.48	0.36	N	0.90	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14506	14506	A	T	MI.23837	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	168	56	F	L	ttT/ttA	2.25	1	0	probably_damaging	1	neutral	0.83	neutral	2.37	neutral	-1.74	deleterious	-5.99	medium_impact	2.2	0.7	neutral	0.16	damaging	1.95	15.91	deleterious	0.3	0.45	0.21	neutral	0.89	disease	0.52	disease	0.57	disease	1	1	deleterious	0.42	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	0.59	medium_impact	0.7	medium_impact	0.68	0.85	50	8.48	0.35	N	0.90	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14507	14507	A	T	MI.23838	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	167	56	F	Y	tTt/tAt	1.79	1	0	probably_damaging	1	neutral	0.24	neutral	2.14	deleterious	-3.3	deleterious	-2.99	medium_impact	2.99	0.69	neutral	0.12	damaging	3.38	23.00	deleterious	0.22	0.45	0.4	neutral	0.94	disease	0.64	disease	0.8	disease	6	1	deleterious	0.12	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	-0.07	medium_impact	1.37	medium_impact	0.64	0.8	50	8.48	0.42	N	0.88	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14507	14507	A	C	MI.23839	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	167	56	F	C	tTt/tGt	1.79	1	0	probably_damaging	1	deleterious	0.02	neutral	2.12	deleterious	-6.26	deleterious	-7.98	high_impact	3.88	0.6	neutral	0.09	damaging	3.39	23.00	deleterious	0.21	0.45	0.86	disease	0.96	disease	0.69	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.55	low_impact	-0.73	medium_impact	2.11	high_impact	0.42	0.8	50	8.48	0.51	P	0.98	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6138	6138	G	T	MI.2384	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	235	79	G	C	Ggc/Tgc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.39	deleterious	-6.03	high_impact	5.13	0.4	damaging	0.01	damaging	4.06	23.70	deleterious	0.2	0.55	0.81	disease	0.94	disease	0.69	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.56	0.9	1.95	6.64	0.57	P	0.98	disease_causing	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14507	14507	A	G	MI.23840	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	167	56	F	S	tTt/tCt	1.79	1	0	probably_damaging	1	neutral	0.08	neutral	2.13	deleterious	-4.88	deleterious	-7.98	high_impact	3.88	0.52	damaging	0.12	damaging	3.91	23.50	deleterious	0.22	0.45	0.74	disease	0.95	disease	0.65	disease	0.81	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.38	medium_impact	2.11	high_impact	0.58	0.8	50	8.48	0.53	P	0.97	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14508	14508	A	G	MI.23841	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	166	56	F	L	Ttt/Ctt	6.61	1	0	probably_damaging	1	neutral	0.83	neutral	2.37	neutral	-1.74	deleterious	-5.99	medium_impact	2.2	0.7	neutral	0.16	damaging	1.97	16.01	deleterious	0.3	0.45	0.21	neutral	0.89	disease	0.52	disease	0.57	disease	1	1	deleterious	0.42	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	0.59	medium_impact	0.7	medium_impact	0.68	0.85	50	8.48	0.46	N	0.90	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14508	14508	A	C	MI.23842	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	166	56	F	V	Ttt/Gtt	6.61	1	0	probably_damaging	1	neutral	0.36	neutral	2.28	neutral	-2.82	deleterious	-6.99	medium_impact	2.79	0.7	neutral	0.24	damaging	3.15	22.60	deleterious	0.25	0.45	0.48	neutral	0.96	disease	0.64	disease	0.6	disease	2	1	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-3.55	low_impact	0.07	medium_impact	1.2	medium_impact	0.68	0.85	50	8.48	0.51	N	0.95	NA	NA	0.62	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14508	14508	A	T	MI.23843	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	166	56	F	I	Ttt/Att	6.61	1	0	probably_damaging	1	neutral	0.51	neutral	2.54	deleterious	-3.02	deleterious	-5.99	high_impact	3.88	0.62	neutral	0.12	damaging	3.42	23.00	deleterious	0.19	0.45	0.45	neutral	0.96	disease	0.63	disease	0.81	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	0.22	medium_impact	2.11	high_impact	0.72	0.85	50	8.48	0.58	P	0.92	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14510	14510	A	G	MI.23844	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	164	55	V	A	gTt/gCt	-6.7	0	0	possibly_damaging	0.46	deleterious	0.03	neutral	2.23	deleterious	-3.38	deleterious	-3.87	medium_impact	3.39	0.73	neutral	0.55	neutral	1.76	14.76	neutral	0.3	0.45	0.39	neutral	0.72	disease	0.58	disease	0.72	disease	4	0.97	neutral	0.29	neutral	4	deleterious	0.47	deleterious	-0.73	medium_impact	-0.63	medium_impact	1.7	medium_impact	0.47	0.8	49.12	8.68	0.42	N	0.69	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14510	14510	A	T	MI.23845	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	164	55	V	D	gTt/gAt	-6.7	0	0	probably_damaging	0.93	deleterious	0.01	neutral	2.17	deleterious	-6.28	deleterious	-6.81	medium_impact	3.39	0.53	damaging	0.38	neutral	3.72	23.30	deleterious	0.12	0.4	0.81	disease	0.91	disease	0.7	disease	0.83	disease	7	1	deleterious	0.04	neutral	5	deleterious	0.82	deleterious	-1.83	low_impact	-0.9	medium_impact	1.7	medium_impact	0.68	0.85	49.12	8.68	0.32	N	0.94	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14510	14510	A	C	MI.23846	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	164	55	V	G	gTt/gGt	-6.7	0	0	possibly_damaging	0.82	neutral	0.15	neutral	2.18	deleterious	-5.28	deleterious	-6.8	medium_impact	3.04	0.5	damaging	0.49	neutral	3.03	22.30	deleterious	0.17	0.45	0.73	disease	0.81	disease	0.59	disease	0.77	disease	5	0.92	neutral	0.17	neutral	0	NA	0.77	deleterious	-1.4	low_impact	-0.21	medium_impact	1.41	medium_impact	0.58	0.8	49.12	8.68	0.38	N	0.86	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14511	14511	C	G	MI.23847	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	163	55	V	L	Gtt/Ctt	4.54	0.39	0	benign	0.04	neutral	1	neutral	2.49	neutral	0.45	deleterious	-2.75	neutral_impact	0.52	0.68	neutral	0.54	neutral	1.74	14.63	neutral	0.37	0.5	0.12	neutral	0.33	neutral	0.35	neutral	0.43	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.13	neutral	0.47	medium_impact	1.87	high_impact	-0.7	medium_impact	0.70	0.85	49.12	8.68	0.37	N	0.57	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14511	14511	C	T	MI.23848	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	163	55	V	I	Gtt/Att	4.54	0.39	0	benign	0.33	neutral	0.17	neutral	2.32	neutral	-0.35	neutral	-0.94	medium_impact	3.39	0.51	damaging	0.48	neutral	1.96	15.98	deleterious	0.4	0.5	0.21	neutral	0.66	disease	0.54	disease	0.7	disease	4	0.8	neutral	0.42	neutral	-3	neutral	0.38	neutral	-0.51	medium_impact	-0.18	medium_impact	1.7	medium_impact	0.84	0.9	49.12	8.68	0.53	P	0.39	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14511	14511	C	A	MI.23849	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	163	55	V	F	Gtt/Ttt	4.54	0.39	0	possibly_damaging	0.79	neutral	0.36	neutral	2.25	neutral	-1.4	deleterious	-4.75	medium_impact	2.58	0.58	damaging	0.48	neutral	3.91	23.50	deleterious	0.18	0.45	0.53	disease	0.88	disease	0.54	disease	0.74	disease	5	0.81	neutral	0.29	neutral	0	NA	0.72	deleterious	-1.32	low_impact	0.07	medium_impact	1.02	medium_impact	0.70	0.85	49.12	8.68	0.41	N	0.90	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6138	6138	G	C	MI.2385	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	235	79	G	R	Ggc/Cgc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-3.22	deleterious	-5.36	high_impact	5.13	0.44	damaging	0.02	damaging	3.81	23.40	deleterious	0.16	0.55	0.63	disease	0.95	disease	0.78	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.66	0.9	1.95	6.64	0.63	P	0.95	disease_causing	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14512	14512	T	A	MI.23850	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	162	54	M	I	atA/atT	-0.04	0	0	benign	0.01	neutral	0.64	neutral	2.43	neutral	0.86	deleterious	-3.53	low_impact	1.5	0.83	neutral	0.93	neutral	1.04	10.89	neutral	0.36	0.5	0.14	neutral	0.69	disease	0.42	neutral	0.53	disease	1	0.34	neutral	0.82	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	0.35	medium_impact	0.12	medium_impact	0.72	0.85	28.32	24.19	0.28	N	0.80	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14512	14512	T	G	MI.23851	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	162	54	M	I	atA/atC	-0.04	0	0	benign	0.01	neutral	0.64	neutral	2.43	neutral	0.86	deleterious	-3.53	low_impact	1.5	0.83	neutral	0.93	neutral	0.71	8.90	deleterious	0.36	0.5	0.14	neutral	0.69	disease	0.42	neutral	0.53	disease	1	0.34	neutral	0.82	deleterious	-6	neutral	0.20	neutral	1.03	medium_impact	0.35	medium_impact	0.12	medium_impact	0.72	0.85	28.32	24.19	0.28	N	0.80	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14513	14513	A	T	MI.23852	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	161	54	M	K	aTa/aAa	-9.45	0	0	possibly_damaging	0.46	deleterious	0.03	neutral	2.2	neutral	-2.74	deleterious	-5.77	medium_impact	3.44	0.68	neutral	0.35	neutral	2.16	17.23	deleterious	0.13	0.4	0.56	disease	0.94	disease	0.67	disease	0.87	disease	7	0.97	neutral	0.29	neutral	4	deleterious	0.60	deleterious	-0.73	medium_impact	-0.63	medium_impact	1.74	medium_impact	0.64	0.8	28.32	24.19	0.36	N	0.95	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14513	14513	A	G	MI.23853	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	161	54	M	T	aTa/aCa	-9.45	0	0	benign	0.2	neutral	0.07	neutral	2.41	neutral	-1.58	deleterious	-5.62	medium_impact	2.75	0.79	neutral	0.71	neutral	1.24	11.93	neutral	0.28	0.45	0.38	neutral	0.84	disease	0.57	disease	0.8	disease	6	0.92	neutral	0.44	neutral	-3	neutral	0.41	neutral	-0.24	medium_impact	-0.42	medium_impact	1.16	medium_impact	0.51	0.8	28.32	24.19	0.31	N	0.87	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14514	14514	T	A	MI.23854	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	160	54	M	L	Ata/Tta	4.31	0.22	0	benign	0.02	neutral	0.98	neutral	2.42	neutral	0.13	deleterious	-2.76	medium_impact	2.35	0.87	neutral	0.68	neutral	0.59	8.07	deleterious	0.29	0.45	0.18	neutral	0.86	disease	0.42	neutral	0.73	disease	5	0	neutral	0.98	deleterious	-3	neutral	0.23	neutral	0.75	medium_impact	1.15	medium_impact	0.83	medium_impact	0.68	0.85	28.32	24.19	0.36	N	0.71	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14514	14514	T	G	MI.23855	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	160	54	M	L	Ata/Cta	4.31	0.22	0	benign	0.02	neutral	0.98	neutral	2.42	neutral	0.13	deleterious	-2.76	medium_impact	2.35	0.87	neutral	0.68	neutral	0.49	7.36	deleterious	0.29	0.45	0.18	neutral	0.86	disease	0.42	neutral	0.73	disease	5	0	neutral	0.98	deleterious	-3	neutral	0.23	neutral	0.75	medium_impact	1.15	medium_impact	0.83	medium_impact	0.68	0.85	28.32	24.19	0.39	N	0.71	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14514	14514	T	C	MI.23856	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	160	54	M	V	Ata/Gta	4.31	0.22	0	benign	0	neutral	1	neutral	2.36	neutral	1.74	deleterious	-3.47	low_impact	1.02	0.9	neutral	0.92	neutral	-0.64	0.10	neutral	0.36	0.5	0.11	neutral	0.37	neutral	0.42	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	1.87	high_impact	-0.29	medium_impact	0.71	0.85	28.32	24.19	0.45	N	0.60	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14515	14515	T	A	MI.23857	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	159	53	L	F	ttA/ttT	-0.5	0	0	probably_damaging	1	neutral	0.13	neutral	2.09	deleterious	-4.63	deleterious	-3.94	high_impact	3.64	0.59	damaging	0.09	damaging	3.87	23.50	deleterious	0.37	0.5	0.56	disease	0.89	disease	0.7	disease	0.79	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.82	deleterious	-3.55	low_impact	-0.25	medium_impact	1.91	medium_impact	0.76	0.85	11.95	17.19	0.34	N	0.95	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14515	14515	T	G	MI.23858	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	159	53	L	F	ttA/ttC	-0.5	0	0	probably_damaging	1	neutral	0.13	neutral	2.09	deleterious	-4.63	deleterious	-3.94	high_impact	3.64	0.59	damaging	0.09	damaging	3.63	23.20	deleterious	0.37	0.5	0.56	disease	0.89	disease	0.7	disease	0.79	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.82	deleterious	-3.55	low_impact	-0.25	medium_impact	1.91	medium_impact	0.76	0.85	11.95	17.19	0.32	N	0.95	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14516	14516	A	G	MI.23859	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	158	53	L	S	tTa/tCa	-6.01	0	0	probably_damaging	1	neutral	0.07	neutral	1.91	deleterious	-6.14	deleterious	-5.96	high_impact	3.64	0.5	damaging	0.06	damaging	3.82	23.40	deleterious	0.19	0.45	0.81	disease	0.91	disease	0.7	disease	0.79	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.42	medium_impact	1.91	medium_impact	0.75	0.85	11.95	17.19	0.3	N	0.97	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6138	6138	G	A	MI.2386	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	235	79	G	S	Ggc/Agc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-0.8	deleterious	-4.02	high_impact	4.16	0.49	damaging	0.02	damaging	4.08	23.70	deleterious	0.26	0.55	0.33	neutral	0.89	disease	0.68	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.74	high_impact	0.70	0.9	1.95	6.64	0.4	N	0.73	disease_causing	0.97	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14516	14516	A	C	MI.23860	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	158	53	L	W	tTa/tGa	-6.01	0	0	probably_damaging	1	deleterious	0.04	neutral	1.88	deleterious	-7.79	deleterious	-5.95	high_impact	3.99	0.41	damaging	0.04	damaging	3.38	22.90	deleterious	0.14	0.4	0.9	disease	0.91	disease	0.73	disease	0.83	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-3.55	low_impact	-0.56	medium_impact	2.2	high_impact	0.77	0.85	11.95	17.19	0.47	N	0.98	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14517	14517	A	T	MI.23861	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	157	53	L	M	Tta/Ata	4.54	0.25	0	probably_damaging	1	neutral	0.09	neutral	1.98	deleterious	-4.34	neutral	-1.98	medium_impact	3.19	0.68	neutral	0.17	damaging	3.19	22.70	deleterious	0.31	0.45	0.5	disease	0.84	disease	0.63	disease	0.69	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.55	low_impact	-0.35	medium_impact	1.53	medium_impact	0.80	0.85	11.95	17.19	0.45	N	0.87	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14517	14517	A	C	MI.23862	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	157	53	L	V	Tta/Gta	4.54	0.25	0	probably_damaging	1	neutral	0.16	neutral	2.05	deleterious	-3.33	deleterious	-2.97	medium_impact	3.19	0.65	neutral	0.24	damaging	2.99	22.20	deleterious	0.31	0.45	0.38	neutral	0.86	disease	0.56	disease	0.56	disease	1	1	deleterious	0.08	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	-0.19	medium_impact	1.53	medium_impact	0.79	0.85	11.95	17.19	0.43	N	0.71	NA	NA	0.68	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14519	14519	C	T	MI.23863	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	155	52	G	D	gGt/gAt	-6.24	0	0	probably_damaging	1	neutral	0.2	neutral	1.85	deleterious	-5.11	deleterious	-6.97	high_impact	3.63	0.6	neutral	0.05	damaging	3.97	23.60	deleterious	0.17	0.45	0.58	disease	0.96	disease	0.67	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	-0.13	medium_impact	1.9	medium_impact	0.73	0.85	12.83	8.79	0.28	N	0.96	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14519	14519	C	G	MI.23864	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	155	52	G	A	gGt/gCt	-6.24	0	0	probably_damaging	1	neutral	0.51	neutral	2.11	neutral	-0.91	deleterious	-5.98	medium_impact	2	0.66	neutral	0.32	neutral	3.34	22.90	deleterious	0.39	0.5	0.31	neutral	0.81	disease	0.37	neutral	0.59	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.77	deleterious	-3.55	low_impact	0.22	medium_impact	0.54	medium_impact	0.84	0.9	12.83	8.79	0.26	N	0.78	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14519	14519	C	A	MI.23865	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	155	52	G	V	gGt/gTt	-6.24	0	0	probably_damaging	1	neutral	0.5	neutral	1.89	deleterious	-3.18	deleterious	-8.97	high_impact	3.63	0.55	damaging	0.08	damaging	4.30	24.00	deleterious	0.16	0.45	0.56	disease	0.95	disease	0.6	disease	0.84	disease	7	1	deleterious	0.25	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.21	medium_impact	1.9	medium_impact	0.86	0.9	12.83	8.79	0.34	N	0.98	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14520	14520	C	T	MI.23866	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	154	52	G	S	Ggt/Agt	2.71	0.94	0	probably_damaging	1	neutral	0.41	neutral	2.01	neutral	-1.61	deleterious	-5.97	low_impact	1.23	0.6	neutral	0.4	neutral	4.32	24.00	deleterious	0.34	0.5	0.11	neutral	0.24	neutral	0.31	neutral	0.42	neutral	2	1	deleterious	0.21	neutral	-2	neutral	0.64	deleterious	-3.55	low_impact	0.12	medium_impact	-0.11	medium_impact	0.80	0.85	12.83	8.79	0.39	N	1.00	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14520	14520	C	G	MI.23867	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	154	52	G	R	Ggt/Cgt	2.71	0.94	0	probably_damaging	1	neutral	0.35	neutral	1.86	deleterious	-4.56	deleterious	-7.97	high_impact	3.63	0.6	damaging	0.04	damaging	4.14	23.80	deleterious	0.13	0.4	0.65	disease	0.98	disease	0.69	disease	0.87	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.06	medium_impact	1.9	medium_impact	0.78	0.85	12.83	8.79	0.45	N	1.00	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14520	14520	C	A	MI.23868	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	154	52	G	C	Ggt/Tgt	2.71	0.94	0	probably_damaging	1	neutral	0.18	neutral	1.85	deleterious	-4.81	deleterious	-8.97	medium_impact	3.08	0.69	neutral	0.15	damaging	4.64	24.50	deleterious	0.15	0.45	0.71	disease	0.95	disease	0.53	disease	0.76	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.55	low_impact	-0.16	medium_impact	1.44	medium_impact	0.81	0.85	12.83	8.79	0.45	N	0.97	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14521	14521	C	G	MI.23869	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	153	51	M	I	atG/atC	3.17	0.94	0	benign	0.06	neutral	0.37	neutral	2.43	neutral	-1.56	neutral	-0.42	low_impact	1.01	0.67	neutral	0.67	neutral	1.91	15.64	deleterious	0.58	0.65	0.16	neutral	0.75	disease	0.47	neutral	0.58	disease	2	0.59	neutral	0.66	deleterious	-6	neutral	0.22	neutral	0.3	medium_impact	0.08	medium_impact	-0.29	medium_impact	0.72	0.85	20.8	18.4	0.43	N	0.62	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6139	6139	G	A	MI.2387	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	236	79	G	D	gGc/gAc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-3.75	deleterious	-4.69	high_impact	5.13	0.32	damaging	0.01	damaging	3.71	23.30	deleterious	0.19	0.55	0.68	disease	0.92	disease	0.78	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.54	0.9	1.95	6.64	0.79	P	0.97	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14521	14521	C	A	MI.23870	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	153	51	M	I	atG/atT	3.17	0.94	0	benign	0.06	neutral	0.37	neutral	2.43	neutral	-1.56	neutral	-0.42	low_impact	1.01	0.67	neutral	0.67	neutral	2.32	18.33	deleterious	0.58	0.65	0.16	neutral	0.75	disease	0.47	neutral	0.58	disease	2	0.59	neutral	0.66	deleterious	-6	neutral	0.22	neutral	0.3	medium_impact	0.08	medium_impact	-0.29	medium_impact	0.72	0.85	20.8	18.4	0.43	N	0.62	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14522	14522	A	G	MI.23871	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	152	51	M	T	aTg/aCg	-4.86	0	0	benign	0.14	neutral	0.08	neutral	2.29	deleterious	-3.3	deleterious	-3.3	medium_impact	2.48	0.54	damaging	0.64	neutral	1.35	12.55	neutral	0.49	0.55	0.43	neutral	0.73	disease	0.65	disease	0.73	disease	5	0.91	neutral	0.47	deleterious	-3	neutral	0.33	neutral	-0.07	medium_impact	-0.38	medium_impact	0.94	medium_impact	0.63	0.8	20.8	18.4	0.43	N	0.78	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14522	14522	A	T	MI.23872	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	152	51	M	K	aTg/aAg	-4.86	0	0	benign	0.42	deleterious	0.03	neutral	2.27	deleterious	-4.56	deleterious	-4.23	medium_impact	2.48	0.54	damaging	0.52	neutral	3.35	22.90	deleterious	0.32	0.5	0.62	disease	0.92	disease	0.72	disease	0.84	disease	7	0.97	neutral	0.31	neutral	1	deleterious	0.56	deleterious	-0.67	medium_impact	-0.63	medium_impact	0.94	medium_impact	0.76	0.85	20.8	18.4	0.33	N	0.90	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14523	14523	T	A	MI.23873	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	151	51	M	L	Atg/Ttg	8.44	1	0	benign	0	neutral	1	neutral	2.84	neutral	1.6	neutral	1.07	neutral_impact	-0.72	0.9	neutral	0.98	neutral	-0.98	0.02	neutral	0.55	0.6	0.19	neutral	0.4	neutral	0.43	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	1.87	high_impact	-1.74	low_impact	0.72	0.85	20.8	18.4	0.61	P	0.22	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14523	14523	T	G	MI.23874	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	151	51	M	L	Atg/Ctg	8.44	1	0	benign	0	neutral	1	neutral	2.84	neutral	1.6	neutral	1.07	neutral_impact	-0.72	0.9	neutral	0.98	neutral	-1.07	0.01	neutral	0.55	0.6	0.19	neutral	0.4	neutral	0.43	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.12	neutral	1.95	medium_impact	1.87	high_impact	-1.74	low_impact	0.72	0.85	20.8	18.4	0.61	P	0.22	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14523	14523	T	C	MI.23875	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	151	51	M	V	Atg/Gtg	8.44	1	0	benign	0	neutral	0.23	neutral	2.41	neutral	-1.84	neutral	-1.13	neutral_impact	0.66	0.79	neutral	0.84	neutral	0.58	8.05	deleterious	0.6	0.65	0.13	neutral	0.66	disease	0.5	neutral	0.44	neutral	1	0.77	neutral	0.62	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	-0.09	medium_impact	-0.59	medium_impact	0.73	0.85	20.8	18.4	0.59	P	0.60	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14525	14525	T	C	MI.23876	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	149	50	Y	C	tAt/tGt	1.56	1	0	probably_damaging	0.99	deleterious	0.02	neutral	2.25	deleterious	-4.78	deleterious	-5.26	medium_impact	2.39	0.76	neutral	0.17	damaging	3.30	22.80	deleterious	0.31	0.45	0.82	disease	0.91	disease	0.69	disease	0.83	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.87	deleterious	-2.63	low_impact	-0.73	medium_impact	0.86	medium_impact	0.35	0.8	17.7	19.1	0.4	N	0.77	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14525	14525	T	A	MI.23877	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	149	50	Y	F	tAt/tTt	1.56	1	0	benign	0.14	neutral	1	neutral	2.77	neutral	2.61	neutral	2.53	neutral_impact	-0.74	0.86	neutral	0.88	neutral	0.85	9.76	deleterious	0.29	0.45	0.14	neutral	0.31	neutral	0.49	neutral	0.4	neutral	2	0.14	neutral	0.93	deleterious	-6	neutral	0.29	neutral	-0.07	medium_impact	1.87	high_impact	-1.76	low_impact	0.56	0.8	17.7	19.1	0.38	N	0.25	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14525	14525	T	G	MI.23878	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	149	50	Y	S	tAt/tCt	1.56	1	0	probably_damaging	0.97	neutral	0.38	neutral	2.26	deleterious	-3.21	deleterious	-5.26	medium_impact	2.39	0.75	neutral	0.21	damaging	3.88	23.50	deleterious	0.24	0.45	0.65	disease	0.85	disease	0.64	disease	0.81	disease	6	0.97	neutral	0.21	neutral	1	deleterious	0.83	deleterious	-2.18	low_impact	0.09	medium_impact	0.86	medium_impact	0.40	0.8	17.7	19.1	0.43	N	0.81	NA	NA	0.61	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14526	14526	A	G	MI.23879	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	148	50	Y	H	Tat/Cat	5.46	1	0	probably_damaging	0.98	neutral	0.06	neutral	2.24	neutral	-2.75	deleterious	-4.06	medium_impact	2.39	0.72	neutral	0.2	damaging	3.53	23.10	deleterious	0.29	0.45	0.49	neutral	0.81	disease	0.74	disease	0.79	disease	6	0.99	deleterious	0.04	neutral	1	deleterious	0.81	deleterious	-2.35	low_impact	-0.46	medium_impact	0.86	medium_impact	0.62	0.8	17.7	19.1	0.56	P	0.72	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6139	6139	G	C	MI.2388	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	236	79	G	A	gGc/gCc	6.14	1	0	probably_damaging	1	deleterious	0.01	neutral	2.79	neutral	-0.09	deleterious	-4.02	medium_impact	2.96	0.56	damaging	0.03	damaging	2.99	22.20	deleterious	0.32	0.55	0.33	neutral	0.85	disease	0.61	disease	0.54	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-0.92	medium_impact	1.63	medium_impact	0.72	0.9	1.95	6.64	0.4	N	0.64	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14526	14526	A	C	MI.23880	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	148	50	Y	D	Tat/Gat	5.46	1	0	probably_damaging	0.98	deleterious	0.02	neutral	2.24	deleterious	-4.47	deleterious	-6.25	medium_impact	2.39	0.74	neutral	0.18	damaging	3.51	23.10	deleterious	0.15	0.4	0.81	disease	0.93	disease	0.73	disease	0.86	disease	7	1	deleterious	0.02	neutral	5	deleterious	0.89	deleterious	-2.35	low_impact	-0.73	medium_impact	0.86	medium_impact	0.38	0.8	17.7	19.1	0.53	N	0.92	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14526	14526	A	T	MI.23881	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	148	50	Y	N	Tat/Aat	5.46	1	0	probably_damaging	0.98	deleterious	0.04	neutral	2.25	deleterious	-3.66	deleterious	-6.19	medium_impact	2.39	0.72	neutral	0.27	damaging	3.51	23.10	deleterious	0.24	0.45	0.68	disease	0.91	disease	0.65	disease	0.82	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.86	deleterious	-2.35	low_impact	-0.56	medium_impact	0.86	medium_impact	0.38	0.8	17.7	19.1	0.52	P	0.86	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14528	14528	C	G	MI.23882	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	146	49	G	A	gGt/gCt	-4.86	0	0	benign	0.01	neutral	0.5	neutral	2.36	neutral	0.54	neutral	0.88	neutral_impact	-0.06	0.91	neutral	0.77	neutral	1.29	12.24	neutral	0.36	0.5	0.18	neutral	0.69	disease	0.54	disease	0.56	disease	1	0.49	neutral	0.75	deleterious	-6	neutral	0.19	neutral	1.03	medium_impact	0.21	medium_impact	-1.19	low_impact	0.81	0.85	44.25	12.31	0.27	N	0.11	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14528	14528	C	A	MI.23883	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	146	49	G	V	gGt/gTt	-4.86	0	0	benign	0.01	neutral	0.5	neutral	2.35	neutral	-0.97	neutral	-1.8	neutral_impact	0.39	0.84	neutral	0.74	neutral	2.26	17.89	deleterious	0.24	0.45	0.38	neutral	0.87	disease	0.52	disease	0.61	disease	2	0.48	neutral	0.75	deleterious	-6	neutral	0.28	neutral	1.03	medium_impact	0.21	medium_impact	-0.81	medium_impact	0.77	0.85	44.25	12.31	0.23	N	0.73	NA	NA	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14528	14528	C	T	MI.23884	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	146	49	G	D	gGt/gAt	-4.86	0	0	benign	0.39	neutral	0.2	neutral	2.36	neutral	-1.16	neutral	-0.14	low_impact	1.59	0.72	neutral	0.43	neutral	3.59	23.20	deleterious	0.19	0.45	0.44	neutral	0.89	disease	0.62	disease	0.81	disease	6	0.76	neutral	0.41	neutral	-6	neutral	0.52	deleterious	-0.62	medium_impact	-0.13	medium_impact	0.19	medium_impact	0.67	0.85	44.25	12.31	0.36	N	0.64	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14529	14529	C	T	MI.23885	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	145	49	G	S	Ggt/Agt	1.56	0.06	0	benign	0.02	neutral	0.41	neutral	2.5	neutral	3.1	neutral	3.52	neutral_impact	-1.94	0.87	neutral	0.87	neutral	-0.11	1.67	neutral	0.4	0.5	0.15	neutral	0.16	neutral	0.31	neutral	0.24	neutral	5	0.57	neutral	0.7	deleterious	-6	neutral	0.10	neutral	0.75	medium_impact	0.12	medium_impact	-2.77	low_impact	0.87	0.9	44.25	12.31	0.32	N	0.30	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14529	14529	C	G	MI.23886	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	145	49	G	R	Ggt/Cgt	1.56	0.06	0	possibly_damaging	0.6	neutral	0.34	neutral	2.31	neutral	-1.29	neutral	-0.99	low_impact	1.59	0.8	neutral	0.44	neutral	3.93	23.50	deleterious	0.22	0.45	0.46	neutral	0.94	disease	0.63	disease	0.87	disease	7	0.68	neutral	0.37	neutral	-3	neutral	0.72	deleterious	-0.96	medium_impact	0.05	medium_impact	0.19	medium_impact	0.89	0.9	44.25	12.31	0.29	N	0.69	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14529	14529	C	A	MI.23887	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	145	49	G	C	Ggt/Tgt	1.56	0.06	0	possibly_damaging	0.87	neutral	0.18	neutral	2.28	neutral	-2.43	neutral	-1.11	low_impact	0.9	0.78	neutral	0.54	neutral	4.53	24.30	deleterious	0.19	0.45	0.56	disease	0.88	disease	0.5	neutral	0.75	disease	5	0.93	neutral	0.16	neutral	-3	neutral	0.75	deleterious	-1.55	low_impact	-0.16	medium_impact	-0.39	medium_impact	0.81	0.85	44.25	12.31	0.34	N	0.64	NA	NA	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14531	14531	C	T	MI.23888	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	143	48	G	E	gGa/gAa	-12.43	0	0	probably_damaging	1	neutral	0.27	neutral	2.34	neutral	-1.37	deleterious	-7.99	medium_impact	3.02	0.72	neutral	0.09	damaging	2.49	19.39	deleterious	0.26	0.45	0.6	disease	0.96	disease	0.8	disease	0.92	disease	8	1	deleterious	0.14	neutral	1	deleterious	0.85	deleterious	-3.55	low_impact	-0.03	medium_impact	1.39	medium_impact	0.69	0.85	19.47	20.58	0.38	N	0.95	NA	NA	0.61	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14531	14531	C	A	MI.23889	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	143	48	G	V	gGa/gTa	-12.43	0	0	probably_damaging	1	neutral	0.5	neutral	2.32	neutral	-2.16	deleterious	-8.98	medium_impact	2.02	0.74	neutral	0.22	damaging	4.10	23.70	deleterious	0.25	0.45	0.34	neutral	0.88	disease	0.58	disease	0.59	disease	2	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	0.21	medium_impact	0.55	medium_impact	0.81	0.85	19.47	20.58	0.3	N	0.98	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6139	6139	G	T	MI.2389	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	236	79	G	V	gGc/gTc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-1.51	deleterious	-6.03	high_impact	4.78	0.47	damaging	0.02	damaging	3.67	23.20	deleterious	0.18	0.55	0.51	disease	0.95	disease	0.7	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.62	0.9	1.95	6.64	0.66	P	0.93	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14531	14531	C	G	MI.23890	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	143	48	G	A	gGa/gCa	-12.43	0	0	probably_damaging	1	neutral	0.51	neutral	2.42	neutral	-1.53	deleterious	-5.99	medium_impact	2.42	0.78	neutral	0.53	neutral	3.23	22.80	deleterious	0.31	0.5	0.33	neutral	0.86	disease	0.54	disease	0.58	disease	2	1	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	0.22	medium_impact	0.89	medium_impact	0.72	0.85	19.47	20.58	0.28	N	0.72	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14532	14532	C	G	MI.23891	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	142	48	G	R	Gga/Cga	0.41	0	0	probably_damaging	1	neutral	0.35	neutral	2.32	neutral	-1.83	deleterious	-7.99	high_impact	3.7	0.68	neutral	0.06	damaging	4.08	23.70	deleterious	0.19	0.45	0.66	disease	0.97	disease	0.8	disease	0.92	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.06	medium_impact	1.96	medium_impact	0.85	0.9	19.47	20.58	0.43	N	0.96	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14532	14532	C	A	MI.23892	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	142	48	G	W	Gga/Tga	0.41	0	0	probably_damaging	1	neutral	0.19	neutral	2.28	neutral	-0.89	deleterious	-7.99	medium_impact	3.36	0.75	neutral	0.08	damaging	4.74	24.60	deleterious	0.21	0.45	0.92	disease	0.96	disease	0.73	disease	0.85	disease	7	1	deleterious	0.1	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	-0.14	medium_impact	1.68	medium_impact	0.61	0.8	19.47	20.58	0.37	N	0.97	NA	NA	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14534	14534	C	G	MI.23893	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	140	47	G	A	gGg/gCg	-7.38	0	0	probably_damaging	1	neutral	0.5	neutral	2.08	deleterious	-3.22	deleterious	-5.79	high_impact	3.96	0.46	damaging	0.09	damaging	3.21	22.70	deleterious	0.28	0.45	0.71	disease	0.95	disease	0.81	disease	0.91	disease	8	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.21	medium_impact	2.18	high_impact	0.48	0.8	22.12	21.76	0.48	N	0.74	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14534	14534	C	A	MI.23894	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	140	47	G	V	gGg/gTg	-7.38	0	0	probably_damaging	1	neutral	0.5	neutral	2.06	deleterious	-4.54	deleterious	-8.74	high_impact	3.96	0.34	damaging	0.05	damaging	4.11	23.70	deleterious	0.18	0.45	0.87	disease	0.98	disease	0.82	disease	0.91	disease	8	1	deleterious	0.25	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	0.21	medium_impact	2.18	high_impact	0.64	0.8	22.12	21.76	0.6	P	0.98	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14534	14534	C	T	MI.23895	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	140	47	G	E	gGg/gAg	-7.38	0	0	probably_damaging	1	neutral	0.27	neutral	2.09	neutral	-2.61	deleterious	-7.69	medium_impact	2.49	0.62	neutral	0.51	neutral	2.42	18.97	deleterious	0.24	0.45	0.84	disease	0.97	disease	0.77	disease	0.72	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.90	deleterious	-3.55	low_impact	-0.03	medium_impact	0.95	medium_impact	0.55	0.8	22.12	21.76	0.38	N	0.79	NA	NA	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14535	14535	C	G	MI.23896	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	139	47	G	R	Ggg/Cgg	2.71	0.66	0	probably_damaging	1	neutral	0.34	neutral	2.04	deleterious	-4.18	deleterious	-7.7	high_impact	3.96	0.37	damaging	0.04	damaging	4.01	23.60	deleterious	0.17	0.45	0.88	disease	0.98	disease	0.83	disease	0.91	disease	8	1	deleterious	0.17	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.05	medium_impact	2.18	high_impact	0.67	0.85	22.12	21.76	0.71	P	0.96	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14535	14535	C	A	MI.23897	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	139	47	G	W	Ggg/Tgg	2.71	0.66	0	probably_damaging	1	neutral	0.2	neutral	2	deleterious	-7.78	deleterious	-7.82	high_impact	3.96	0.43	damaging	0.04	damaging	4.75	24.70	deleterious	0.16	0.45	0.97	disease	0.98	disease	0.83	disease	0.86	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	-0.13	medium_impact	2.18	high_impact	0.45	0.8	22.12	21.76	0.58	P	0.98	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14536	14536	A	T	MI.23898	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	138	46	F	L	ttT/ttA	2.02	0.66	0	benign	0	neutral	0.71	neutral	2.79	neutral	0.03	deleterious	-4.3	neutral_impact	0.36	0.87	neutral	0.93	neutral	0.68	8.66	deleterious	0.45	0.55	0.27	neutral	0.59	disease	0.44	neutral	0.46	neutral	1	0.28	neutral	0.86	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	0.42	medium_impact	-0.84	medium_impact	0.64	0.8	49.56	8.75	0.34	N	0.54	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14536	14536	A	C	MI.23899	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	138	46	F	L	ttT/ttG	2.02	0.66	0	benign	0	neutral	0.71	neutral	2.79	neutral	0.03	deleterious	-4.3	neutral_impact	0.36	0.87	neutral	0.93	neutral	0.47	7.18	deleterious	0.45	0.55	0.27	neutral	0.59	disease	0.44	neutral	0.46	neutral	1	0.28	neutral	0.86	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	0.42	medium_impact	-0.84	medium_impact	0.64	0.8	49.56	8.75	0.32	N	0.54	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8639	8639	T	G	MI.239	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	113	38	I	S	aTc/aGc	-3.8	0	0	probably_damaging	0.99	neutral	0.42	neutral	4.27	neutral	-1.65	deleterious	-3.84	low_impact	1.36	0.89	neutral	0.57	neutral	4.08	23.70	deleterious	0.44	0.65	0.63	disease	0.68	disease	0.42	neutral	0.57	disease	1	0.99	deleterious	0.22	neutral	-2	neutral	0.77	deleterious	-2.65	low_impact	0.21	medium_impact	0.07	medium_impact	0.38	0.9	15.49	18.25	0.3	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6141	6141	A	T	MI.2390	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	238	80	N	Y	Aac/Tac	-8.9	0	0	probably_damaging	1	deleterious	0	neutral	2.83	neutral	-0.98	deleterious	-5.45	high_impact	4.86	0.55	damaging	0.12	damaging	3.68	23.30	deleterious	0.27	0.55	0.66	disease	0.92	disease	0.72	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.49	0.9	2.34	6.63	0.62	P	0.93	polymorphism	0.88	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14537	14537	A	C	MI.23900	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	137	46	F	C	tTt/tGt	-0.96	0	0	benign	0	neutral	0.19	neutral	2.28	deleterious	-4.5	deleterious	-6.16	low_impact	1.33	0.92	neutral	0.93	neutral	0.45	7.03	deleterious	0.24	0.45	0.83	disease	0.9	disease	0.55	disease	0.69	disease	4	0.81	neutral	0.6	deleterious	-6	neutral	0.31	neutral	1.95	medium_impact	-0.14	medium_impact	-0.03	medium_impact	0.52	0.8	49.56	8.75	0.42	N	0.02	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14537	14537	A	T	MI.23901	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	137	46	F	Y	tTt/tAt	-0.96	0	0	benign	0	neutral	1	neutral	2.31	neutral	-0.56	neutral	-1.92	low_impact	1.12	0.95	neutral	0.97	neutral	0.22	4.93	deleterious	0.42	0.5	0.2	neutral	0.75	disease	0.48	neutral	0.58	disease	2	0	neutral	1	deleterious	-6	neutral	0.19	neutral	1.95	medium_impact	1.87	high_impact	-0.2	medium_impact	0.61	0.8	49.56	8.75	0.34	N	0.02	NA	NA	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14537	14537	A	G	MI.23902	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	137	46	F	S	tTt/tCt	-0.96	0	0	benign	0.14	neutral	0.46	neutral	2.3	neutral	-2.83	deleterious	-6.05	low_impact	1.69	0.83	neutral	0.97	neutral	1.21	11.82	neutral	0.41	0.5	0.66	disease	0.83	disease	0.57	disease	0.65	disease	3	0.46	neutral	0.66	deleterious	-6	neutral	0.42	neutral	-0.07	medium_impact	0.17	medium_impact	0.28	medium_impact	0.68	0.85	49.56	8.75	0.31	N	0.48	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14538	14538	A	C	MI.23903	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	136	46	F	V	Ttt/Gtt	-0.27	0	0	benign	0.09	neutral	0.52	neutral	2.36	neutral	-1.99	deleterious	-5.31	low_impact	1.92	0.74	neutral	0.63	neutral	1.74	14.64	neutral	0.36	0.5	0.55	disease	0.9	disease	0.63	disease	0.65	disease	3	0.4	neutral	0.72	deleterious	-6	neutral	0.32	neutral	0.13	medium_impact	0.23	medium_impact	0.47	medium_impact	0.73	0.85	49.56	8.75	0.29	N	0.52	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14538	14538	A	G	MI.23904	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	136	46	F	L	Ttt/Ctt	-0.27	0	0	benign	0	neutral	0.71	neutral	2.79	neutral	0.03	deleterious	-4.3	neutral_impact	0.36	0.87	neutral	0.93	neutral	0.61	8.25	deleterious	0.45	0.55	0.27	neutral	0.59	disease	0.44	neutral	0.46	neutral	1	0.28	neutral	0.86	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	0.42	medium_impact	-0.84	medium_impact	0.64	0.8	49.56	8.75	0.3	N	0.54	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14538	14538	A	T	MI.23905	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	136	46	F	I	Ttt/Att	-0.27	0	0	benign	0.09	neutral	0.42	neutral	2.36	neutral	-2.22	deleterious	-4.52	medium_impact	2.52	0.72	neutral	0.52	neutral	1.99	16.17	deleterious	0.25	0.45	0.58	disease	0.84	disease	0.62	disease	0.79	disease	6	0.52	neutral	0.67	deleterious	-3	neutral	0.32	neutral	0.13	medium_impact	0.13	medium_impact	0.97	medium_impact	0.68	0.85	49.56	8.75	0.31	N	0.49	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14539	14539	A	C	MI.23906	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	135	45	N	K	aaT/aaG	0.64	0	0	benign	0.14	neutral	0.3	neutral	2.34	neutral	0.96	neutral	-2.29	low_impact	1.63	0.75	neutral	0.51	neutral	0.53	7.63	deleterious	0.62	0.65	0.22	neutral	0.82	disease	0.62	disease	0.77	disease	5	0.65	neutral	0.58	deleterious	-6	neutral	0.29	neutral	-0.07	medium_impact	0	medium_impact	0.23	medium_impact	0.73	0.85	18.14	18.2	0.43	N	0.74	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14539	14539	A	T	MI.23907	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	135	45	N	K	aaT/aaA	0.64	0	0	benign	0.14	neutral	0.3	neutral	2.34	neutral	0.96	neutral	-2.29	low_impact	1.63	0.75	neutral	0.51	neutral	0.59	8.08	deleterious	0.62	0.65	0.22	neutral	0.82	disease	0.62	disease	0.77	disease	5	0.65	neutral	0.58	deleterious	-6	neutral	0.29	neutral	-0.07	medium_impact	0	medium_impact	0.23	medium_impact	0.73	0.85	18.14	18.2	0.38	N	0.74	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14540	14540	T	C	MI.23908	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	134	45	N	S	aAt/aGt	-1.65	0	0	benign	0.01	neutral	0.41	neutral	2.4	neutral	2.22	neutral	0.32	neutral_impact	-0.2	0.91	neutral	0.98	neutral	-1.82	0.00	neutral	0.66	0.7	0.12	neutral	0.25	neutral	0.37	neutral	0.41	neutral	2	0.58	neutral	0.7	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.12	medium_impact	-1.31	low_impact	0.39	0.8	18.14	18.2	0.39	N	0.09	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14540	14540	T	G	MI.23909	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	134	45	N	T	aAt/aCt	-1.65	0	0	benign	0.14	neutral	0.39	neutral	2.38	neutral	2	neutral	-1.76	low_impact	1.74	0.75	neutral	0.66	neutral	0.73	9.04	deleterious	0.49	0.55	0.26	neutral	0.63	disease	0.51	disease	0.59	disease	2	0.54	neutral	0.63	deleterious	-6	neutral	0.24	neutral	-0.07	medium_impact	0.1	medium_impact	0.32	medium_impact	0.64	0.8	18.14	18.2	0.4	N	0.47	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6141	6141	A	G	MI.2391	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	238	80	N	D	Aac/Gac	-8.9	0	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-4.24	deleterious	-3.4	high_impact	5.2	0.52	damaging	0.15	damaging	3.78	23.40	deleterious	0.6	0.65	0.85	disease	0.83	disease	0.77	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.68	0.9	2.34	6.63	0.67	P	0.92	polymorphism	0.98	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14540	14540	T	A	MI.23910	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	134	45	N	I	aAt/aTt	-1.65	0	0	possibly_damaging	0.48	neutral	0.4	neutral	2.42	neutral	2.5	deleterious	-4.25	low_impact	1.88	0.73	neutral	0.57	neutral	2.34	18.44	deleterious	0.34	0.5	0.41	neutral	0.8	disease	0.51	disease	0.71	disease	4	0.57	neutral	0.46	neutral	-3	neutral	0.42	neutral	-0.76	medium_impact	0.11	medium_impact	0.44	medium_impact	0.56	0.8	18.14	18.2	0.34	N	0.86	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14541	14541	T	G	MI.23911	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	133	45	N	H	Aat/Cat	-2.34	0	0	possibly_damaging	0.52	neutral	0.54	neutral	2.31	neutral	-0.89	neutral	-2.3	medium_impact	2.44	0.73	neutral	0.52	neutral	2.06	16.62	deleterious	0.47	0.55	0.45	neutral	0.65	disease	0.62	disease	0.75	disease	5	0.49	neutral	0.51	deleterious	0	NA	0.49	deleterious	-0.83	medium_impact	0.25	medium_impact	0.9	medium_impact	0.74	0.85	18.14	18.2	0.26	N	0.50	NA	NA	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14541	14541	T	C	MI.23912	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	133	45	N	D	Aat/Gat	-2.34	0	0	benign	0.01	neutral	0.21	neutral	2.31	neutral	-1.46	neutral	-1.92	low_impact	1.15	0.82	neutral	0.6	neutral	0.12	3.82	deleterious	0.63	0.7	0.29	neutral	0.62	disease	0.5	neutral	0.45	neutral	1	0.79	neutral	0.6	deleterious	-6	neutral	0.19	neutral	1.03	medium_impact	-0.11	medium_impact	-0.18	medium_impact	0.65	0.8	18.14	18.2	0.44	N	0.68	NA	NA	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14541	14541	T	A	MI.23913	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	133	45	N	Y	Aat/Tat	-2.34	0	0	benign	0	neutral	1	neutral	2.35	neutral	1.18	deleterious	-3.36	neutral_impact	0.48	0.93	neutral	0.78	neutral	2.65	20.50	deleterious	0.36	0.5	0.52	disease	0.8	disease	0.42	neutral	0.61	disease	2	0	neutral	1	deleterious	-6	neutral	0.27	neutral	1.95	medium_impact	1.87	high_impact	-0.74	medium_impact	0.69	0.85	18.14	18.2	0.25	N	0.88	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14543	14543	A	C	MI.23914	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	131	44	L	R	cTg/cGg	-4.4	0	0	probably_damaging	0.99	neutral	0.09	neutral	1.96	deleterious	-3.51	deleterious	-4.74	medium_impact	3.23	0.6	neutral	0.42	neutral	3.74	23.30	deleterious	0.18	0.45	0.77	disease	0.94	disease	0.71	disease	0.88	disease	8	1	deleterious	0.05	neutral	1	deleterious	0.89	deleterious	-2.63	low_impact	-0.35	medium_impact	1.57	medium_impact	0.84	0.9	21.24	19.09	0.31	N	0.94	NA	NA	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14543	14543	A	G	MI.23915	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	131	44	L	P	cTg/cCg	-4.4	0	0	probably_damaging	0.99	neutral	0.05	neutral	1.95	deleterious	-4.25	deleterious	-5.18	medium_impact	3.23	0.61	neutral	0.35	neutral	3.91	23.50	deleterious	0.15	0.45	0.81	disease	0.95	disease	0.59	disease	0.84	disease	7	1	deleterious	0.03	neutral	1	deleterious	0.89	deleterious	-2.63	low_impact	-0.5	medium_impact	1.57	medium_impact	0.68	0.85	21.24	19.09	0.31	N	0.90	NA	NA	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14543	14543	A	T	MI.23916	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	131	44	L	Q	cTg/cAg	-4.4	0	0	probably_damaging	0.99	neutral	0.08	neutral	1.95	deleterious	-3.59	deleterious	-4.26	medium_impact	3.23	0.61	neutral	0.5	neutral	3.64	23.20	deleterious	0.23	0.45	0.77	disease	0.82	disease	0.59	disease	0.78	disease	6	1	deleterious	0.05	neutral	1	deleterious	0.84	deleterious	-2.63	low_impact	-0.38	medium_impact	1.57	medium_impact	0.87	0.9	21.24	19.09	0.34	N	0.94	NA	NA	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14544	14544	G	C	MI.23917	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	130	44	L	V	Ctg/Gtg	5.92	0.56	0	benign	0.36	neutral	1	neutral	2.03	neutral	0.62	neutral	-0.81	neutral_impact	0.52	0.83	neutral	0.96	neutral	1.39	12.74	neutral	0.52	0.6	0.12	neutral	0.18	neutral	0.26	neutral	0.25	neutral	5	0.36	neutral	0.82	deleterious	-6	neutral	0.42	neutral	-0.57	medium_impact	1.87	high_impact	-0.7	medium_impact	0.87	0.9	21.24	19.09	0.44	N	0.44	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14544	14544	G	T	MI.23918	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	130	44	L	M	Ctg/Atg	5.92	0.56	0	probably_damaging	0.98	neutral	0.34	neutral	2.01	neutral	-2.71	neutral	-0.3	low_impact	1.52	0.84	neutral	0.96	neutral	1.67	14.24	neutral	0.33	0.5	0.37	neutral	0.5	neutral	0.33	neutral	0.48	neutral	0	0.99	deleterious	0.18	neutral	-2	neutral	0.71	deleterious	-2.35	low_impact	0.05	medium_impact	0.13	medium_impact	0.74	0.85	21.24	19.09	0.45	N	0.65	NA	NA	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14545	14545	A	T	MI.23919	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	129	43	I	M	atT/atA	-0.96	0	0	benign	0.06	neutral	0.27	neutral	2.28	neutral	-0.38	neutral	-2.21	low_impact	1.5	0.85	neutral	0.6	neutral	1.14	11.41	neutral	0.37	0.5	0.42	neutral	0.68	disease	0.51	disease	0.58	disease	2	0.7	neutral	0.61	deleterious	-6	neutral	0.24	neutral	0.3	medium_impact	-0.03	medium_impact	0.12	medium_impact	0.86	0.9	31.42	20.88	0.37	N	0.68	NA	NA	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6141	6141	A	C	MI.2392	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	238	80	N	H	Aac/Cac	-8.9	0	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.83	deleterious	-3.4	high_impact	5.2	0.57	damaging	0.12	damaging	3.06	22.40	deleterious	0.4	0.55	0.85	disease	0.87	disease	0.77	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.48	0.9	2.34	6.63	0.69	P	0.83	polymorphism	0.97	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14545	14545	A	C	MI.23920	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	129	43	I	M	atT/atG	-0.96	0	0	benign	0.06	neutral	0.27	neutral	2.28	neutral	-0.38	neutral	-2.21	low_impact	1.5	0.85	neutral	0.6	neutral	1.08	11.11	neutral	0.37	0.5	0.42	neutral	0.68	disease	0.51	disease	0.58	disease	2	0.7	neutral	0.61	deleterious	-6	neutral	0.24	neutral	0.3	medium_impact	-0.03	medium_impact	0.12	medium_impact	0.86	0.9	31.42	20.88	0.41	N	0.68	NA	NA	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14546	14546	A	G	MI.23921	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	128	43	I	T	aTt/aCt	-4.86	0	0	benign	0.01	neutral	0.12	neutral	2.21	neutral	-1.64	deleterious	-3.34	low_impact	1.44	0.75	neutral	0.37	neutral	2.98	22.20	deleterious	0.42	0.55	0.38	neutral	0.76	disease	0.58	disease	0.74	disease	5	0.88	neutral	0.56	deleterious	-6	neutral	0.24	neutral	1.03	medium_impact	-0.27	medium_impact	0.07	medium_impact	0.82	0.85	31.42	20.88	0.37	N	0.82	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14546	14546	A	C	MI.23922	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	128	43	I	S	aTt/aGt	-4.86	0	0	benign	0.22	neutral	0.24	neutral	2.2	neutral	-1.72	deleterious	-5.08	medium_impact	2.54	0.7	neutral	0.51	neutral	3.68	23.30	deleterious	0.28	0.45	0.26	neutral	0.88	disease	0.6	disease	0.82	disease	6	0.71	neutral	0.51	deleterious	-3	neutral	0.36	neutral	-0.29	medium_impact	-0.07	medium_impact	0.99	medium_impact	0.76	0.85	31.42	20.88	0.44	N	0.91	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14546	14546	A	T	MI.23923	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	128	43	I	N	aTt/aAt	-4.86	0	0	possibly_damaging	0.6	neutral	0.11	neutral	2.16	deleterious	-3.73	deleterious	-6.08	medium_impact	2.54	0.69	neutral	0.4	neutral	3.89	23.50	deleterious	0.32	0.5	0.62	disease	0.9	disease	0.63	disease	0.82	disease	6	0.89	neutral	0.26	neutral	0	NA	0.60	deleterious	-0.96	medium_impact	-0.3	medium_impact	0.99	medium_impact	0.71	0.85	31.42	20.88	0.39	N	0.96	NA	NA	0.62	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14547	14547	T	A	MI.23924	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	127	43	I	F	Att/Ttt	1.79	0	0	possibly_damaging	0.52	neutral	0.25	neutral	2.33	neutral	0.06	deleterious	-3.89	medium_impact	2.54	0.72	neutral	0.43	neutral	3.86	23.40	deleterious	0.32	0.5	0.44	neutral	0.88	disease	0.63	disease	0.82	disease	6	0.73	neutral	0.37	neutral	0	NA	0.56	deleterious	-0.83	medium_impact	-0.06	medium_impact	0.99	medium_impact	0.86	0.9	31.42	20.88	0.36	N	0.83	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14547	14547	T	G	MI.23925	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	127	43	I	L	Att/Ctt	1.79	0	0	benign	0.06	neutral	1	neutral	2.44	neutral	0.79	neutral	-1.92	neutral_impact	-0.3	0.75	neutral	0.76	neutral	2.00	16.20	deleterious	0.31	0.5	0.14	neutral	0.32	neutral	0.34	neutral	0.43	neutral	1	0.06	neutral	0.97	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	1.87	high_impact	-1.39	low_impact	0.77	0.85	31.42	20.88	0.31	N	0.64	NA	NA	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14547	14547	T	C	MI.23926	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	127	43	I	V	Att/Gtt	1.79	0	0	benign	0.01	neutral	0.21	neutral	2.27	neutral	-0.57	neutral	0.39	neutral_impact	-0.3	0.92	neutral	0.97	neutral	-1.87	0.00	neutral	0.39	0.5	0.1	neutral	0.45	neutral	0.35	neutral	0.42	neutral	2	0.79	neutral	0.6	deleterious	-6	neutral	0.11	neutral	1.03	medium_impact	-0.11	medium_impact	-1.39	low_impact	0.70	0.85	31.42	20.88	0.48	N	0.04	NA	NA	0.18	.	.	.	.	.	.	COSM1138270	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14548	14548	A	T	MI.23927	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	126	42	I	M	atT/atA	-0.04	0	0	possibly_damaging	0.73	neutral	0.22	neutral	1.99	neutral	-2.75	neutral	-2.06	low_impact	1.74	0.85	neutral	0.91	neutral	-0.25	0.88	neutral	0.36	0.5	0.23	neutral	0.61	disease	0.42	neutral	0.47	neutral	1	0.84	neutral	0.25	neutral	-3	neutral	0.58	deleterious	-1.19	low_impact	-0.1	medium_impact	0.32	medium_impact	0.86	0.9	25.22	18.79	0.4	N	0.36	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14548	14548	A	C	MI.23928	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	126	42	I	M	atT/atG	-0.04	0	0	possibly_damaging	0.73	neutral	0.22	neutral	1.99	neutral	-2.75	neutral	-2.06	low_impact	1.74	0.85	neutral	0.91	neutral	-0.30	0.65	neutral	0.36	0.5	0.23	neutral	0.61	disease	0.42	neutral	0.47	neutral	1	0.84	neutral	0.25	neutral	-3	neutral	0.58	deleterious	-1.19	low_impact	-0.1	medium_impact	0.32	medium_impact	0.86	0.9	25.22	18.79	0.39	N	0.36	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14549	14549	A	T	MI.23929	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	125	42	I	N	aTt/aAt	-1.65	0	0	possibly_damaging	0.88	neutral	0.31	neutral	1.95	deleterious	-4.38	deleterious	-6.25	medium_impact	3.35	0.8	neutral	0.42	neutral	3.81	23.40	deleterious	0.34	0.5	0.54	disease	0.89	disease	0.67	disease	0.8	disease	6	0.9	neutral	0.22	neutral	0	NA	0.77	deleterious	-1.59	low_impact	0.01	medium_impact	1.67	medium_impact	0.61	0.8	25.22	18.79	0.3	N	0.81	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6142	6142	A	C	MI.2393	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	239	80	N	T	aAc/aCc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.44	deleterious	-4.08	high_impact	4.86	0.58	damaging	0.13	damaging	3.29	22.80	deleterious	0.44	0.55	0.78	disease	0.89	disease	0.7	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.55	0.9	2.34	6.63	0.74	P	0.59	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14549	14549	A	G	MI.23930	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	125	42	I	T	aTt/aCt	-1.65	0	0	possibly_damaging	0.46	neutral	0.39	neutral	1.99	neutral	-2.81	deleterious	-4.23	medium_impact	3	0.66	neutral	0.35	neutral	1.69	14.33	neutral	0.39	0.5	0.32	neutral	0.8	disease	0.6	disease	0.73	disease	5	0.57	neutral	0.47	neutral	0	NA	0.47	deleterious	-0.73	medium_impact	0.1	medium_impact	1.37	medium_impact	0.76	0.85	25.22	18.79	0.33	N	0.66	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14549	14549	A	C	MI.23931	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	125	42	I	S	aTt/aGt	-1.65	0	0	possibly_damaging	0.73	neutral	0.4	neutral	2	neutral	-2.61	deleterious	-5.18	medium_impact	3.35	0.67	neutral	0.38	neutral	2.27	17.94	deleterious	0.3	0.45	0.37	neutral	0.91	disease	0.63	disease	0.8	disease	6	0.74	neutral	0.34	neutral	0	NA	0.68	deleterious	-1.19	low_impact	0.11	medium_impact	1.67	medium_impact	0.71	0.85	25.22	18.79	0.43	N	0.75	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14550	14550	T	C	MI.23932	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	124	42	I	V	Att/Gtt	2.71	0.01	0	benign	0.02	neutral	0.5	neutral	2.12	neutral	-1.18	neutral	-0.67	neutral_impact	0.62	0.92	neutral	0.9	neutral	-0.45	0.29	neutral	0.34	0.5	0.15	neutral	0.26	neutral	0.33	neutral	0.43	neutral	2	0.48	neutral	0.74	deleterious	-6	neutral	0.12	neutral	0.75	medium_impact	0.21	medium_impact	-0.62	medium_impact	0.70	0.85	25.22	18.79	0.41	N	0.07	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14550	14550	T	A	MI.23933	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	124	42	I	F	Att/Ttt	2.71	0.01	0	possibly_damaging	0.66	neutral	0.7	neutral	2.05	neutral	-1.8	deleterious	-3.52	medium_impact	2.44	0.71	neutral	0.51	neutral	2.40	18.83	deleterious	0.33	0.5	0.36	neutral	0.89	disease	0.59	disease	0.76	disease	5	0.59	neutral	0.52	deleterious	0	NA	0.65	deleterious	-1.06	low_impact	0.41	medium_impact	0.9	medium_impact	0.83	0.9	25.22	18.79	0.38	N	0.53	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14550	14550	T	G	MI.23934	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	124	42	I	L	Att/Ctt	2.71	0.01	0	benign	0.02	neutral	0.65	neutral	2.2	neutral	-0.62	neutral	-1.4	low_impact	0.95	0.82	neutral	0.92	neutral	0.60	8.17	deleterious	0.28	0.45	0.18	neutral	0.65	disease	0.38	neutral	0.46	neutral	1	0.32	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.36	medium_impact	-0.34	medium_impact	0.70	0.85	25.22	18.79	0.39	N	0.34	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14552	14552	A	C	MI.23935	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	122	41	V	G	gTt/gGt	-10.6	0	0.02	benign	0	neutral	0.4	neutral	2.3	neutral	-2.87	neutral	4.35	neutral_impact	-0.69	0.82	neutral	0.96	neutral	-1.32	0.00	neutral	0.3	0.45	0.09	neutral	0.2	neutral	0.36	neutral	0.31	neutral	4	0.6	neutral	0.7	deleterious	-6	neutral	0.11	neutral	1.95	medium_impact	0.11	medium_impact	-1.72	low_impact	0.65	0.8	44.69	8.36	0.36	N	0.08	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14552	14552	A	G	MI.23936	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	122	41	V	A	gTt/gCt	-10.6	0	0.02	benign	0	neutral	0.52	neutral	2.36	neutral	-1.65	neutral	1.58	neutral_impact	-0.04	0.96	neutral	0.98	neutral	0.18	4.42	deleterious	0.4	0.5	0.17	neutral	0.54	disease	0.39	neutral	0.44	neutral	1	0.47	neutral	0.76	deleterious	-6	neutral	0.18	neutral	1.95	medium_impact	0.23	medium_impact	-1.17	low_impact	0.76	0.85	44.69	8.36	0.28	N	0.01	NA	NA	0.18	.	.	.	.	.	pancreatic cancer cell line	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14552	14552	A	T	MI.23937	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	122	41	V	D	gTt/gAt	-10.6	0	0.02	benign	0.28	neutral	0.2	neutral	2.17	deleterious	-3.49	neutral	-0.09	medium_impact	2.19	0.67	neutral	0.49	neutral	2.17	17.30	deleterious	0.17	0.45	0.47	neutral	0.87	disease	0.62	disease	0.82	disease	6	0.76	neutral	0.46	neutral	-3	neutral	0.44	deleterious	-0.42	medium_impact	-0.13	medium_impact	0.7	medium_impact	0.71	0.85	44.69	8.36	0.44	N	0.53	NA	NA	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14553	14553	C	A	MI.23938	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	121	41	V	F	Gtt/Ttt	-0.73	0	0	benign	0.22	neutral	0.7	neutral	2.4	deleterious	-3.95	neutral	-0.69	low_impact	1.38	0.81	neutral	0.73	neutral	1.14	11.43	neutral	0.21	0.45	0.34	neutral	0.87	disease	0.35	neutral	0.74	disease	5	0.19	neutral	0.74	deleterious	-6	neutral	0.49	deleterious	-0.29	medium_impact	0.41	medium_impact	0.02	medium_impact	0.69	0.85	44.69	8.36	0.25	N	0.39	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14553	14553	C	T	MI.23939	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	121	41	V	I	Gtt/Att	-0.73	0	0	benign	0	neutral	0.41	neutral	2.28	neutral	-2.88	neutral	-0.65	low_impact	1.38	0.74	neutral	0.6	neutral	0.44	6.95	deleterious	0.5	0.6	0.17	neutral	0.46	neutral	0.47	neutral	0.48	neutral	0	0.58	neutral	0.71	deleterious	-6	neutral	0.16	neutral	1.95	medium_impact	0.12	medium_impact	0.02	medium_impact	0.75	0.85	44.69	8.36	0.44	N	0.25	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6142	6142	A	T	MI.2394	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	239	80	N	I	aAc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-1.59	deleterious	-6.13	high_impact	4.65	0.57	damaging	0.12	damaging	3.86	23.50	deleterious	0.27	0.55	0.58	disease	0.95	disease	0.61	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.43	0.9	2.34	6.63	0.53	P	0.98	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14553	14553	C	G	MI.23940	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	121	41	V	L	Gtt/Ctt	-0.73	0	0	benign	0.03	neutral	0.67	neutral	2.43	neutral	-2.57	neutral	-0.64	neutral_impact	0.56	0.86	neutral	0.92	neutral	-0.28	0.74	neutral	0.4	0.5	0.1	neutral	0.6	disease	0.31	neutral	0.43	neutral	1	0.28	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.59	medium_impact	0.38	medium_impact	-0.67	medium_impact	0.87	0.9	44.69	8.36	0.28	N	0.21	NA	NA	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14554	14554	A	C	MI.23941	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	120	40	C	W	tgT/tgG	-0.27	0	0.01	probably_damaging	1	neutral	0.08	neutral	2.22	deleterious	-7.64	deleterious	-10.98	high_impact	3.99	0.48	damaging	0.07	damaging	3.80	23.40	deleterious	0.19	0.45	0.96	disease	0.99	disease	0.84	disease	0.84	disease	7	1	deleterious	0.04	neutral	2	deleterious	0.94	deleterious	-3.55	low_impact	-0.38	medium_impact	2.2	high_impact	0.44	0.8	48.67	8.5	0.47	N	0.96	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14554	14554	A	T	MI.23942	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	120	40	C	W	tgT/tgA	-0.27	0	0.01	probably_damaging	1	neutral	0.08	neutral	2.22	deleterious	-7.64	deleterious	-10.98	high_impact	3.99	0.48	damaging	0.07	damaging	3.83	23.40	deleterious	0.19	0.45	0.96	disease	0.99	disease	0.84	disease	0.84	disease	7	1	deleterious	0.04	neutral	2	deleterious	0.94	deleterious	-3.55	low_impact	-0.38	medium_impact	2.2	high_impact	0.44	0.8	48.67	8.5	0.47	N	0.96	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14555	14555	C	T	MI.23943	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	119	40	C	Y	tGt/tAt	1.56	0.73	0	probably_damaging	1	neutral	0.34	neutral	2.23	deleterious	-5.89	deleterious	-10.98	high_impact	3.99	0.51	damaging	0.07	damaging	3.75	23.30	deleterious	0.28	0.45	0.91	disease	0.99	disease	0.8	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.94	deleterious	-3.55	low_impact	0.05	medium_impact	2.2	high_impact	0.69	0.85	48.67	8.5	0.51	N	0.94	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14555	14555	C	A	MI.23944	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	119	40	C	F	tGt/tTt	1.56	0.73	0	probably_damaging	1	neutral	0.34	neutral	2.24	deleterious	-5.52	deleterious	-10.98	high_impact	3.99	0.5	damaging	0.08	damaging	4.21	23.90	deleterious	0.24	0.45	0.89	disease	0.99	disease	0.77	disease	0.88	disease	8	1	deleterious	0.17	neutral	2	deleterious	0.94	deleterious	-3.55	low_impact	0.05	medium_impact	2.2	high_impact	0.55	0.8	48.67	8.5	0.51	P	0.94	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14555	14555	C	G	MI.23945	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	119	40	C	S	tGt/tCt	1.56	0.73	0	probably_damaging	1	neutral	0.46	neutral	2.49	neutral	-2.47	deleterious	-9.98	medium_impact	3.1	0.68	neutral	0.41	neutral	3.21	22.70	deleterious	0.28	0.45	0.74	disease	0.97	disease	0.72	disease	0.82	disease	6	1	deleterious	0.23	neutral	1	deleterious	0.91	deleterious	-3.55	low_impact	0.17	medium_impact	1.46	medium_impact	0.53	0.8	48.67	8.5	0.35	N	0.47	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14556	14556	A	G	MI.23946	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	118	40	C	R	Tgt/Cgt	3.4	0.99	0	probably_damaging	1	neutral	0.1	neutral	2.24	deleterious	-5.18	deleterious	-11.98	high_impact	3.99	0.47	damaging	0.07	damaging	3.41	23.00	deleterious	0.2	0.45	0.88	disease	0.99	disease	0.85	disease	0.89	disease	8	1	deleterious	0.05	neutral	2	deleterious	0.94	deleterious	-3.55	low_impact	-0.32	medium_impact	2.2	high_impact	0.48	0.8	48.67	8.5	0.65	P	0.89	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14556	14556	A	T	MI.23947	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	118	40	C	S	Tgt/Agt	3.4	0.99	0	probably_damaging	1	neutral	0.46	neutral	2.49	neutral	-2.47	deleterious	-9.98	medium_impact	3.1	0.68	neutral	0.41	neutral	2.94	22.00	deleterious	0.28	0.45	0.74	disease	0.97	disease	0.72	disease	0.82	disease	6	1	deleterious	0.23	neutral	1	deleterious	0.91	deleterious	-3.55	low_impact	0.17	medium_impact	1.46	medium_impact	0.53	0.8	48.67	8.5	0.5	N	0.47	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14556	14556	A	C	MI.23948	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	118	40	C	G	Tgt/Ggt	3.4	0.99	0	probably_damaging	1	neutral	0.42	neutral	2.31	deleterious	-3.94	deleterious	-11.98	medium_impact	3.19	0.62	neutral	0.14	damaging	2.80	21.40	deleterious	0.22	0.45	0.76	disease	0.97	disease	0.76	disease	0.87	disease	7	1	deleterious	0.21	neutral	1	deleterious	0.89	deleterious	-3.55	low_impact	0.13	medium_impact	1.53	medium_impact	0.37	0.8	48.67	8.5	0.51	N	0.74	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14558	14558	C	T	MI.23949	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	116	39	G	E	gGg/gAg	-10.6	0	0	probably_damaging	1	neutral	0.27	neutral	2.23	deleterious	-4.98	deleterious	-7.99	high_impact	3.99	0.53	damaging	0.02	damaging	3.94	23.50	deleterious	0.34	0.5	0.79	disease	0.97	disease	0.85	disease	0.91	disease	8	1	deleterious	0.14	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	-0.03	medium_impact	2.2	high_impact	0.80	0.85	18.58	19.57	0.39	N	1.00	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6142	6142	A	G	MI.2395	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	239	80	N	S	aAc/aGc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.69	neutral	-2.98	deleterious	-3.4	high_impact	4.3	0.59	damaging	0.14	damaging	3.02	22.30	deleterious	0.62	0.65	0.77	disease	0.84	disease	0.67	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.64	low_impact	-1.48	low_impact	2.87	high_impact	0.46	0.9	2.34	6.63	0.51	P	0.79	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14558	14558	C	G	MI.23950	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	116	39	G	A	gGg/gCg	-10.6	0	0	probably_damaging	1	neutral	0.51	neutral	2.31	neutral	-2.48	deleterious	-5.99	medium_impact	3.19	0.61	neutral	0.08	damaging	3.19	22.70	deleterious	0.47	0.55	0.44	neutral	0.92	disease	0.73	disease	0.7	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.86	deleterious	-3.55	low_impact	0.22	medium_impact	1.53	medium_impact	0.86	0.9	18.58	19.57	0.28	N	0.78	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14558	14558	C	A	MI.23951	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	116	39	G	V	gGg/gTg	-10.6	0	0	probably_damaging	1	neutral	0.51	neutral	2.46	deleterious	-4.25	deleterious	-8.98	high_impact	3.64	0.5	damaging	0.04	damaging	4.13	23.80	deleterious	0.27	0.45	0.66	disease	0.98	disease	0.78	disease	0.9	disease	8	1	deleterious	0.26	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	0.22	medium_impact	1.91	medium_impact	0.77	0.85	18.58	19.57	0.4	N	0.98	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14559	14559	C	A	MI.23952	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	115	39	G	W	Ggg/Tgg	5	0.96	0	probably_damaging	1	neutral	0.19	neutral	2.23	deleterious	-8.05	deleterious	-7.99	high_impact	3.99	0.54	damaging	0.01	damaging	4.73	24.60	deleterious	0.22	0.45	0.95	disease	0.97	disease	0.81	disease	0.9	disease	8	1	deleterious	0.1	neutral	2	deleterious	0.93	deleterious	-3.55	low_impact	-0.14	medium_impact	2.2	high_impact	0.59	0.8	18.58	19.57	0.57	P	1.00	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14559	14559	C	G	MI.23953	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	115	39	G	R	Ggg/Cgg	5	0.96	0	probably_damaging	1	neutral	0.35	neutral	2.24	deleterious	-5.23	deleterious	-7.99	high_impact	3.99	0.52	damaging	0.02	damaging	4.05	23.70	deleterious	0.19	0.45	0.79	disease	0.97	disease	0.85	disease	0.93	disease	9	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.06	medium_impact	2.2	high_impact	0.79	0.85	18.58	19.57	0.56	P	1.00	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14561	14561	A	G	MI.23954	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	113	38	V	A	gTc/gCc	-5.55	0	0	possibly_damaging	0.69	neutral	0.57	neutral	2.26	neutral	-0.67	deleterious	-2.94	low_impact	1.25	0.85	neutral	0.96	neutral	2.48	19.33	deleterious	0.44	0.55	0.25	neutral	0.39	neutral	0.5	neutral	0.45	neutral	1	0.64	neutral	0.44	neutral	-3	neutral	0.60	deleterious	-1.11	low_impact	0.27	medium_impact	-0.09	medium_impact	0.70	0.85	15.49	18.25	0.28	N	0.72	NA	NA	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14561	14561	A	C	MI.23955	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	113	38	V	G	gTc/gGc	-5.55	0	0	probably_damaging	0.96	neutral	0.45	neutral	2.32	neutral	-0.04	deleterious	-5.86	medium_impact	2.04	0.71	neutral	0.65	neutral	3.86	23.50	deleterious	0.28	0.45	0.64	disease	0.68	disease	0.63	disease	0.55	disease	1	0.96	neutral	0.25	neutral	1	deleterious	0.75	deleterious	-2.06	low_impact	0.16	medium_impact	0.57	medium_impact	0.64	0.8	15.49	18.25	0.29	N	0.90	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14561	14561	A	T	MI.23956	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	113	38	V	D	gTc/gAc	-5.55	0	0	probably_damaging	0.97	neutral	0.2	neutral	2.17	deleterious	-4.46	deleterious	-5.84	medium_impact	3.43	0.62	neutral	0.38	neutral	4.53	24.30	deleterious	0.15	0.4	0.74	disease	0.83	disease	0.8	disease	0.83	disease	7	0.98	deleterious	0.12	neutral	1	deleterious	0.82	deleterious	-2.18	low_impact	-0.13	medium_impact	1.73	medium_impact	0.75	0.85	15.49	18.25	0.38	N	0.90	NA	NA	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14562	14562	C	G	MI.23957	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	112	38	V	L	Gtc/Ctc	1.1	0	0	possibly_damaging	0.45	neutral	0.84	neutral	2.35	neutral	0.28	neutral	-1.77	low_impact	1.67	0.88	neutral	0.85	neutral	0.64	8.45	deleterious	0.42	0.55	0.18	neutral	0.45	neutral	0.44	neutral	0.45	neutral	1	0.34	neutral	0.7	deleterious	-3	neutral	0.41	neutral	-0.72	medium_impact	0.61	medium_impact	0.26	medium_impact	0.80	0.85	15.49	18.25	0.31	N	0.38	NA	NA	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14562	14562	C	A	MI.23958	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	112	38	V	F	Gtc/Ttc	1.1	0	0	probably_damaging	0.92	neutral	0.79	neutral	2.27	neutral	-0.6	deleterious	-3.72	low_impact	1.76	0.85	neutral	0.73	neutral	2.94	22.00	deleterious	0.26	0.45	0.47	neutral	0.74	disease	0.47	neutral	0.59	disease	2	0.91	neutral	0.44	neutral	-2	neutral	0.74	deleterious	-1.77	low_impact	0.53	medium_impact	0.33	medium_impact	0.83	0.85	15.49	18.25	0.22	N	0.82	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14562	14562	C	T	MI.23959	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	112	38	V	I	Gtc/Atc	1.1	0	0	benign	0.06	neutral	0.5	neutral	2.28	neutral	-0.41	neutral	-0.52	medium_impact	2.04	0.91	neutral	0.86	neutral	0.51	7.49	deleterious	0.51	0.6	0.16	neutral	0.37	neutral	0.5	neutral	0.45	neutral	1	0.44	neutral	0.72	deleterious	-3	neutral	0.15	neutral	0.3	medium_impact	0.21	medium_impact	0.57	medium_impact	0.74	0.85	15.49	18.25	0.37	N	0.06	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6143	6143	C	A	MI.2396	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	240	80	N	K	aaC/aaA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.49	deleterious	-4.08	high_impact	5.2	0.43	damaging	0.14	damaging	4.25	23.90	deleterious	0.54	0.6	0.8	disease	0.92	disease	0.77	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.67	0.9	2.34	6.63	0.81	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14564	14564	A	T	MI.23960	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	110	37	V	E	gTg/gAg	-11.05	0	0	possibly_damaging	0.46	neutral	0.27	neutral	2.13	deleterious	-4.03	neutral	-0.03	medium_impact	2.77	0.65	neutral	0.54	neutral	3.79	23.40	deleterious	0.22	0.45	0.42	neutral	0.92	disease	0.78	disease	0.83	disease	6	0.7	neutral	0.41	neutral	0	NA	0.64	deleterious	-0.73	medium_impact	-0.03	medium_impact	1.18	medium_impact	0.73	0.85	20.35	20.89	0.46	N	0.57	NA	NA	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14564	14564	A	G	MI.23961	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	110	37	V	A	gTg/gCg	-11.05	0	0	benign	0	neutral	0.51	neutral	2.17	neutral	-1.87	neutral	2.75	neutral_impact	0.12	0.91	neutral	0.98	neutral	-0.02	2.41	deleterious	0.44	0.55	0.21	neutral	0.51	disease	0.44	neutral	0.45	neutral	1	0.48	neutral	0.76	deleterious	-6	neutral	0.17	neutral	1.95	medium_impact	0.22	medium_impact	-1.04	low_impact	0.67	0.85	20.35	20.89	0.37	N	0.01	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14564	14564	A	C	MI.23962	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	110	37	V	G	gTg/gGg	-11.05	0	0	benign	0.01	neutral	0.33	neutral	2.2	neutral	-1.36	neutral	5.51	neutral_impact	-0.3	0.83	neutral	0.96	neutral	-1.16	0.01	neutral	0.29	0.45	0.12	neutral	0.25	neutral	0.41	neutral	0.42	neutral	2	0.66	neutral	0.66	deleterious	-6	neutral	0.12	neutral	1.03	medium_impact	0.04	medium_impact	-1.39	low_impact	0.65	0.8	20.35	20.89	0.35	N	0.25	NA	NA	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14565	14565	C	G	MI.23963	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	109	37	V	L	Gtg/Ctg	-0.73	0	0	benign	0.11	neutral	0.65	neutral	2.51	neutral	1.01	neutral	-0.95	low_impact	1.45	0.73	neutral	0.73	neutral	1.67	14.24	neutral	0.4	0.5	0.13	neutral	0.66	disease	0.4	neutral	0.47	neutral	1	0.24	neutral	0.77	deleterious	-6	neutral	0.20	neutral	0.04	medium_impact	0.36	medium_impact	0.08	medium_impact	0.77	0.85	20.35	20.89	0.32	N	0.53	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14565	14565	C	A	MI.23964	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	109	37	V	L	Gtg/Ttg	-0.73	0	0	benign	0.11	neutral	0.65	neutral	2.51	neutral	1.01	neutral	-0.95	low_impact	1.45	0.73	neutral	0.73	neutral	2.00	16.24	deleterious	0.4	0.5	0.13	neutral	0.66	disease	0.4	neutral	0.47	neutral	1	0.24	neutral	0.77	deleterious	-6	neutral	0.20	neutral	0.04	medium_impact	0.36	medium_impact	0.08	medium_impact	0.77	0.85	20.35	20.89	0.37	N	0.53	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14565	14565	C	T	MI.23965	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	109	37	V	M	Gtg/Atg	-0.73	0	0	possibly_damaging	0.72	neutral	0.22	neutral	2.18	neutral	-1.74	neutral	-0.29	medium_impact	2.42	0.64	neutral	0.69	neutral	1.94	15.84	deleterious	0.41	0.5	0.32	neutral	0.62	disease	0.59	disease	0.73	disease	5	0.83	neutral	0.25	neutral	0	NA	0.56	deleterious	-1.17	low_impact	-0.1	medium_impact	0.89	medium_impact	0.81	0.85	20.35	20.89	0.45	N	0.54	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14567	14567	C	T	MI.23966	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	107	36	G	D	gGt/gAt	-5.78	0	0	probably_damaging	1	neutral	0.2	neutral	2.28	neutral	-2.58	deleterious	-6.98	high_impact	3.6	0.62	neutral	0.32	neutral	3.95	23.60	deleterious	0.14	0.4	0.62	disease	0.91	disease	0.76	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.13	medium_impact	1.88	medium_impact	0.57	0.8	29.2	23.72	0.38	N	0.96	NA	NA	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14567	14567	C	G	MI.23967	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	107	36	G	A	gGt/gCt	-5.78	0	0	probably_damaging	1	neutral	0.81	neutral	2.43	neutral	1.84	deleterious	-5.99	low_impact	1.25	0.55	damaging	0.41	neutral	3.23	22.80	deleterious	0.42	0.55	0.12	neutral	0.34	neutral	0.35	neutral	0.44	neutral	1	1	deleterious	0.41	neutral	-2	neutral	0.70	deleterious	-3.55	low_impact	0.56	medium_impact	-0.09	medium_impact	0.80	0.85	29.2	23.72	0.3	N	0.78	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14567	14567	C	A	MI.23968	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	107	36	G	V	gGt/gTt	-5.78	0	0	probably_damaging	1	neutral	0.64	neutral	2.41	neutral	1.59	deleterious	-8.98	medium_impact	3.04	0.62	neutral	0.41	neutral	4.07	23.70	deleterious	0.23	0.45	0.53	disease	0.91	disease	0.69	disease	0.78	disease	6	1	deleterious	0.32	neutral	1	deleterious	0.86	deleterious	-3.55	low_impact	0.35	medium_impact	1.41	medium_impact	0.72	0.85	29.2	23.72	0.35	N	0.98	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14568	14568	C	G	MI.23969	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	106	36	G	R	Ggt/Cgt	3.17	0.97	0	probably_damaging	1	neutral	0.33	neutral	2.29	neutral	-1.39	deleterious	-7.98	high_impact	3.6	0.61	neutral	0.26	damaging	3.99	23.60	deleterious	0.13	0.4	0.65	disease	0.93	disease	0.78	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	0.04	medium_impact	1.88	medium_impact	0.76	0.85	29.2	23.72	0.57	P	1.00	NA	NA	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6143	6143	C	G	MI.2397	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	240	80	N	K	aaC/aaG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.49	deleterious	-4.08	high_impact	5.2	0.43	damaging	0.14	damaging	3.87	23.50	deleterious	0.54	0.6	0.8	disease	0.92	disease	0.77	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.67	0.9	2.34	6.63	0.81	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14568	14568	C	A	MI.23970	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	106	36	G	C	Ggt/Tgt	3.17	0.97	0	probably_damaging	1	neutral	0.23	neutral	2.31	neutral	-0.48	deleterious	-8.98	medium_impact	3.25	0.67	neutral	0.27	damaging	4.54	24.30	deleterious	0.21	0.45	0.69	disease	0.92	disease	0.67	disease	0.81	disease	6	1	deleterious	0.12	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	-0.09	medium_impact	1.58	medium_impact	0.79	0.85	29.2	23.72	0.53	P	0.97	NA	NA	0.57	.	.	.	.	.	.	COSM1138272	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14568	14568	C	T	MI.23971	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	106	36	G	S	Ggt/Agt	3.17	0.97	0	probably_damaging	1	neutral	0.64	neutral	2.47	neutral	2.17	deleterious	-5.99	low_impact	1.72	0.27	damaging	0.23	damaging	4.27	24.00	deleterious	0.42	0.55	0.23	neutral	0.52	disease	0.37	neutral	0.46	neutral	1	1	deleterious	0.32	neutral	-2	neutral	0.73	deleterious	-3.55	low_impact	0.35	medium_impact	0.3	medium_impact	0.77	0.85	29.2	23.72	0.9	P	1.00	NA	NA	0.53	rs397515506	Pathogenic	Leber's_optic_atrophy	76423	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	.	C14568T	LHON	+	-	Cfrm	9	P	P	P	neutral
chrM	14570	14570	C	A	MI.23972	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	104	35	S	I	aGc/aTc	-2.57	0	0	probably_damaging	1	neutral	0.48	neutral	2.28	deleterious	-3.6	deleterious	-5.61	high_impact	3.62	0.65	neutral	0.45	neutral	4.34	24.00	deleterious	0.32	0.5	0.44	neutral	0.81	disease	0.65	disease	0.78	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.79	deleterious	-3.55	low_impact	0.19	medium_impact	1.89	medium_impact	0.84	0.9	20.35	18.29	0.37	N	0.98	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14570	14570	C	T	MI.23973	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	104	35	S	N	aGc/aAc	-2.57	0	0	probably_damaging	1	neutral	0.15	neutral	2.22	deleterious	-3.69	deleterious	-2.87	high_impact	3.62	0.76	neutral	0.5	neutral	3.63	23.20	deleterious	0.55	0.6	0.52	disease	0.61	disease	0.64	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.79	deleterious	-3.55	low_impact	-0.21	medium_impact	1.89	medium_impact	0.65	0.8	20.35	18.29	0.39	N	0.86	NA	NA	0.70	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14570	14570	C	G	MI.23974	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	104	35	S	T	aGc/aCc	-2.57	0	0	probably_damaging	1	neutral	0.28	neutral	2.28	neutral	-2.18	deleterious	-2.81	medium_impact	2.92	0.66	neutral	0.52	neutral	3.50	23.10	deleterious	0.31	0.5	0.35	neutral	0.49	neutral	0.42	neutral	0.53	disease	1	1	deleterious	0.14	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	-0.02	medium_impact	1.31	medium_impact	0.71	0.85	20.35	18.29	0.44	N	0.69	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14571	14571	T	A	MI.23975	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	103	35	S	C	Agc/Tgc	0.18	0	0	probably_damaging	1	neutral	0.16	neutral	2.22	deleterious	-5.33	deleterious	-4.6	medium_impact	2.81	0.86	neutral	0.53	neutral	3.47	23.00	deleterious	0.29	0.45	0.57	disease	0.78	disease	0.45	neutral	0.67	disease	3	1	deleterious	0.08	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	-0.19	medium_impact	1.21	medium_impact	0.78	0.85	20.35	18.29	0.38	N	0.99	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14571	14571	T	C	MI.23976	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	103	35	S	G	Agc/Ggc	0.18	0	0	probably_damaging	1	neutral	0.23	neutral	2.23	deleterious	-3.79	deleterious	-3.37	low_impact	1.64	0.87	neutral	0.95	neutral	1.98	16.10	deleterious	0.36	0.5	0.43	neutral	0.37	neutral	0.34	neutral	0.45	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.71	deleterious	-3.55	low_impact	-0.09	medium_impact	0.23	medium_impact	0.65	0.8	20.35	18.29	0.48	N	0.82	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14571	14571	T	G	MI.23977	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	103	35	S	R	Agc/Cgc	0.18	0	0	probably_damaging	1	neutral	0.08	neutral	2.21	deleterious	-3.66	deleterious	-4.65	high_impact	3.62	0.66	neutral	0.31	neutral	3.93	23.50	deleterious	0.19	0.45	0.55	disease	0.84	disease	0.73	disease	0.81	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	-0.38	medium_impact	1.89	medium_impact	0.82	0.85	20.35	18.29	0.36	N	1.00	NA	NA	0.71	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14573	14573	A	G	MI.23978	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	101	34	V	A	gTt/gCt	-9.91	0	0	benign	0.24	neutral	0.44	neutral	2.2	deleterious	-3.89	deleterious	-3.48	medium_impact	2.12	0.88	neutral	0.88	neutral	1.56	13.61	neutral	0.32	0.5	0.53	disease	0.64	disease	0.51	disease	0.52	disease	0	0.47	neutral	0.6	deleterious	-3	neutral	0.36	neutral	-0.34	medium_impact	0.15	medium_impact	0.64	medium_impact	0.68	0.85	9.73	14.65	0.36	N	0.46	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14573	14573	A	T	MI.23979	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	101	34	V	D	gTt/gAt	-9.91	0	0	possibly_damaging	0.84	deleterious	0.04	neutral	2.12	deleterious	-6.61	deleterious	-6.3	medium_impact	3.33	0.68	neutral	0.36	neutral	3.80	23.40	deleterious	0.13	0.4	0.87	disease	0.89	disease	0.73	disease	0.83	disease	7	0.98	neutral	0.1	neutral	4	deleterious	0.77	deleterious	-1.46	low_impact	-0.56	medium_impact	1.65	medium_impact	0.75	0.85	9.73	14.65	0.31	N	0.94	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6144	6144	T	G	MI.2398	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	241	81	W	G	Tga/Gga	0.13	0.97	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.66	deleterious	-8.7	high_impact	4.96	0.64	neutral	0.06	damaging	3.83	23.40	deleterious	0.25	0.55	0.55	disease	0.87	disease	0.73	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.26	0.9	2.92	6.8	0.63	P	0.89	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14573	14573	A	C	MI.23980	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	101	34	V	G	gTt/gGt	-9.91	0	0	possibly_damaging	0.7	neutral	0.24	neutral	2.23	deleterious	-5.76	deleterious	-6.36	medium_impact	2.52	0.69	neutral	0.65	neutral	1.77	14.82	neutral	0.24	0.45	0.81	disease	0.79	disease	0.59	disease	0.69	disease	4	0.81	neutral	0.27	neutral	0	NA	0.70	deleterious	-1.13	low_impact	-0.07	medium_impact	0.97	medium_impact	0.68	0.85	9.73	14.65	0.32	N	0.92	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14574	14574	C	T	MI.23981	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	100	34	V	I	Gtt/Att	1.33	0	0	benign	0.02	neutral	0.75	neutral	2.39	neutral	-2.38	neutral	-0.56	low_impact	0.97	0.89	neutral	0.99	neutral	0.01	2.70	deleterious	0.39	0.5	0.21	neutral	0.39	neutral	0.34	neutral	0.44	neutral	1	0.22	neutral	0.87	deleterious	-6	neutral	0.15	neutral	0.75	medium_impact	0.47	medium_impact	-0.33	medium_impact	0.80	0.85	9.73	14.65	0.38	N	0.04	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14574	14574	C	G	MI.23982	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	100	34	V	L	Gtt/Ctt	1.33	0	0	benign	0.09	neutral	0.81	neutral	2.36	neutral	-1.76	neutral	-2.1	low_impact	1.32	0.85	neutral	0.8	neutral	0.55	7.78	deleterious	0.39	0.5	0.17	neutral	0.41	neutral	0.27	neutral	0.46	neutral	1	0.09	neutral	0.86	deleterious	-6	neutral	0.17	neutral	0.13	medium_impact	0.56	medium_impact	-0.03	medium_impact	0.80	0.85	9.73	14.65	0.3	N	0.66	NA	NA	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14574	14574	C	A	MI.23983	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	100	34	V	F	Gtt/Ttt	1.33	0	0	benign	0.02	neutral	0.28	neutral	2.26	neutral	-2	deleterious	-3.83	low_impact	1.14	0.93	neutral	0.64	neutral	2.76	21.20	deleterious	0.23	0.45	0.59	disease	0.85	disease	0.38	neutral	0.61	disease	2	0.71	neutral	0.63	deleterious	-6	neutral	0.28	neutral	0.75	medium_impact	-0.02	medium_impact	-0.19	medium_impact	0.74	0.85	9.73	14.65	0.47	N	0.85	NA	NA	0.53	rs386829218	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14575	14575	A	C	MI.23984	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	99	33	I	M	atT/atG	-2.11	0	0	possibly_damaging	0.69	neutral	0.28	neutral	1.94	deleterious	-4.33	deleterious	-2.64	medium_impact	2.28	0.71	neutral	0.62	neutral	2.64	20.40	deleterious	0.33	0.5	0.58	disease	0.74	disease	0.55	disease	0.67	disease	3	0.78	neutral	0.3	neutral	0	NA	0.63	deleterious	-1.11	low_impact	-0.02	medium_impact	0.77	medium_impact	0.80	0.85	19.47	19.69	0.36	N	0.87	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14575	14575	A	T	MI.23985	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	99	33	I	M	atT/atA	-2.11	0	0	possibly_damaging	0.69	neutral	0.28	neutral	1.94	deleterious	-4.33	deleterious	-2.64	medium_impact	2.28	0.71	neutral	0.62	neutral	2.69	20.80	deleterious	0.33	0.5	0.58	disease	0.74	disease	0.55	disease	0.67	disease	3	0.78	neutral	0.3	neutral	0	NA	0.63	deleterious	-1.11	low_impact	-0.02	medium_impact	0.77	medium_impact	0.80	0.85	19.47	19.69	0.32	N	0.87	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14576	14576	A	C	MI.23986	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	98	33	I	S	aTt/aGt	-1.19	0	0	benign	0.3	neutral	0.21	neutral	1.89	deleterious	-6.19	deleterious	-5.65	medium_impact	3.18	0.45	damaging	0.34	neutral	2.11	16.91	deleterious	0.24	0.45	0.73	disease	0.92	disease	0.64	disease	0.8	disease	6	0.75	neutral	0.46	neutral	-3	neutral	0.48	deleterious	-0.46	medium_impact	-0.11	medium_impact	1.52	medium_impact	0.55	0.8	19.47	19.69	0.36	N	0.97	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14576	14576	A	T	MI.23987	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	98	33	I	N	aTt/aAt	-1.19	0	0	possibly_damaging	0.69	neutral	0.05	neutral	1.87	deleterious	-7.23	deleterious	-6.65	medium_impact	3.18	0.47	damaging	0.37	neutral	3.78	23.40	deleterious	0.28	0.45	0.84	disease	0.92	disease	0.67	disease	0.81	disease	6	0.96	neutral	0.18	neutral	0	NA	0.68	deleterious	-1.11	low_impact	-0.5	medium_impact	1.52	medium_impact	0.58	0.8	19.47	19.69	0.39	N	0.99	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14576	14576	A	G	MI.23988	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	98	33	I	T	aTt/aCt	-1.19	0	0	benign	0.02	neutral	0.29	neutral	1.9	deleterious	-5.25	deleterious	-4.42	medium_impact	3.18	0.47	damaging	0.36	neutral	1.53	13.45	neutral	0.41	0.5	0.57	disease	0.79	disease	0.64	disease	0.76	disease	5	0.7	neutral	0.64	deleterious	-3	neutral	0.29	neutral	0.75	medium_impact	-0.01	medium_impact	1.52	medium_impact	0.63	0.8	19.47	19.69	0.48	N	0.92	NA	NA	0.67	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14577	14577	T	A	MI.23989	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	97	33	I	F	Att/Ttt	3.85	0.1	0.01	possibly_damaging	0.5	neutral	0.23	neutral	1.91	deleterious	-4.68	deleterious	-3.91	medium_impact	3.18	0.5	damaging	0.37	neutral	3.76	23.30	deleterious	0.34	0.5	0.63	disease	0.91	disease	0.68	disease	0.81	disease	6	0.75	neutral	0.37	neutral	0	NA	0.66	deleterious	-0.8	medium_impact	-0.09	medium_impact	1.52	medium_impact	0.79	0.85	19.47	19.69	0.49	N	0.93	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6144	6144	T	C	MI.2399	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	241	81	W	R	Tga/Cga	0.13	0.97	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.6	deleterious	-9.36	high_impact	4.96	0.6	damaging	0.05	damaging	3.51	23.10	deleterious	0.24	0.55	0.53	disease	0.95	disease	0.78	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.29	0.9	2.92	6.8	0.61	P	0.98	disease_causing	0.98	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14577	14577	T	G	MI.23990	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	97	33	I	L	Att/Ctt	3.85	0.1	0.01	benign	0.01	neutral	0.83	neutral	2.08	neutral	-0.82	neutral	-1.85	medium_impact	2.13	0.67	neutral	0.54	neutral	2.01	16.26	deleterious	0.27	0.45	0.3	neutral	0.77	disease	0.54	disease	0.73	disease	5	0.14	neutral	0.91	deleterious	-3	neutral	0.21	neutral	1.03	medium_impact	0.59	medium_impact	0.64	medium_impact	0.64	0.8	19.47	19.69	0.4	N	0.62	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14577	14577	T	C	MI.23991	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	97	33	I	V	Att/Gtt	3.85	0.1	0.01	benign	0.01	neutral	1	neutral	2.14	neutral	-2.51	neutral	-0.51	neutral_impact	-0.12	0.98	neutral	0.93	neutral	-0.75	0.06	neutral	0.33	0.5	0.1	neutral	0.21	neutral	0.37	neutral	0.32	neutral	4	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.03	medium_impact	1.87	high_impact	-1.24	low_impact	0.59	0.8	19.47	19.69	0.5	N	0.15	NA	NA	0.21	rs386829219	.	.	.	.	.	.	CPD	12.93	T14577C	MIDM	-	+	Reported	1	N	P	N,P	neutral
chrM	14578	14578	C	A	MI.23992	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	96	32	L	F	ttG/ttT	0.41	0.01	0	probably_damaging	1	neutral	0.25	neutral	1.51	deleterious	-5.39	deleterious	-3.98	high_impact	3.65	0.56	damaging	0.1	damaging	3.97	23.60	deleterious	0.33	0.5	0.65	disease	0.89	disease	0.71	disease	0.79	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.06	medium_impact	1.92	medium_impact	0.51	0.8	29.2	19.38	0.3	N	0.95	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14578	14578	C	G	MI.23993	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	96	32	L	F	ttG/ttC	0.41	0.01	0	probably_damaging	1	neutral	0.25	neutral	1.51	deleterious	-5.39	deleterious	-3.98	high_impact	3.65	0.56	damaging	0.1	damaging	3.51	23.10	deleterious	0.33	0.5	0.65	disease	0.89	disease	0.71	disease	0.79	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.06	medium_impact	1.92	medium_impact	0.51	0.8	29.2	19.38	0.32	N	0.95	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14579	14579	A	G	MI.23994	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	95	32	L	S	tTg/tCg	-5.09	0	0	probably_damaging	1	neutral	0.3	neutral	1.45	deleterious	-6.57	deleterious	-5.96	high_impact	4	0.4	damaging	0.04	damaging	3.72	23.30	deleterious	0.17	0.45	0.83	disease	0.93	disease	0.75	disease	0.85	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0	medium_impact	2.21	high_impact	0.61	0.8	29.2	19.38	0.48	N	0.97	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14579	14579	A	C	MI.23995	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	95	32	L	W	tTg/tGg	-5.09	0	0	probably_damaging	1	neutral	0.07	neutral	1.42	deleterious	-8.33	deleterious	-5.97	high_impact	4	0.41	damaging	0.04	damaging	3.28	22.80	deleterious	0.13	0.4	0.92	disease	0.89	disease	0.76	disease	0.86	disease	7	1	deleterious	0.04	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.42	medium_impact	2.21	high_impact	0.57	0.8	29.2	19.38	0.45	N	0.98	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14580	14580	A	T	MI.23996	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	94	32	L	M	Ttg/Atg	5.46	0.55	0	probably_damaging	1	neutral	0.1	neutral	1.47	deleterious	-5.28	neutral	-1.99	high_impact	4	0.5	damaging	0.07	damaging	3.23	22.80	deleterious	0.26	0.45	0.62	disease	0.8	disease	0.69	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.81	deleterious	-3.55	low_impact	-0.32	medium_impact	2.21	high_impact	0.58	0.8	29.2	19.38	0.51	N	0.87	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14582	14582	A	G	MI.23997	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	92	31	V	A	gTa/gCa	-12.89	0	0.03	benign	0.02	neutral	0.54	neutral	2.33	neutral	-0.49	neutral	1.87	neutral_impact	0.18	0.96	neutral	0.89	neutral	-0.52	0.20	neutral	0.43	0.55	0.2	neutral	0.49	neutral	0.36	neutral	0.44	neutral	1	0.44	neutral	0.76	deleterious	-6	neutral	0.17	neutral	0.75	medium_impact	0.25	medium_impact	-0.99	medium_impact	0.78	0.85	28.32	22.32	0.26	N	0.11	NA	NA	0.19	rs41354845	.	.	.	.	.	.	.	.	A14582G	LHON synergistic combo 14258A + 14582G	+	-	Reported: individually neutral variants causing LHON in combination	1	N	.	N	neutral
chrM	14582	14582	A	C	MI.23998	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	92	31	V	G	gTa/gGa	-12.89	0	0.03	benign	0.03	neutral	0.5	neutral	2.3	deleterious	-3.99	neutral	4.59	neutral_impact	-0.95	0.84	neutral	0.96	neutral	-1.20	0.01	neutral	0.3	0.45	0.11	neutral	0.18	neutral	0.33	neutral	0.24	neutral	5	0.47	neutral	0.74	deleterious	-6	neutral	0.11	neutral	0.59	medium_impact	0.21	medium_impact	-1.94	low_impact	0.70	0.85	28.32	22.32	0.31	N	0.30	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14582	14582	A	T	MI.23999	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	92	31	V	E	gTa/gAa	-12.89	0	0.03	possibly_damaging	0.7	neutral	0.27	neutral	2.22	deleterious	-4.02	neutral	-0.24	medium_impact	2.25	0.56	damaging	0.42	neutral	3.51	23.10	deleterious	0.21	0.45	0.3	neutral	0.86	disease	0.66	disease	0.82	disease	6	0.79	neutral	0.29	neutral	0	NA	0.63	deleterious	-1.13	low_impact	-0.03	medium_impact	0.75	medium_impact	0.81	0.85	28.32	22.32	0.35	N	0.63	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8536	8536	A	T	MI.24	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	10	4	N	Y	Aat/Tat	6.84	1	0	possibly_damaging	0.63	deleterious	0	neutral	4.41	neutral	-2.72	deleterious	-5.64	medium_impact	2.85	0.91	neutral	0.36	neutral	3.87	23.50	deleterious	0.47	0.65	0.86	disease	0.53	disease	0.62	disease	0.71	disease	4	1	deleterious	0.19	neutral	4	deleterious	0.62	deleterious	-0.98	medium_impact	-1.4	low_impact	1.35	medium_impact	0.48	0.9	41.59	7.51	0.68	P	0.97	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8639	8639	T	C	MI.240	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	113	38	I	T	aTc/aCc	-3.8	0	0	probably_damaging	0.99	neutral	0.14	neutral	4.29	neutral	-1.18	deleterious	-2.86	low_impact	1.82	0.96	neutral	0.96	neutral	2.18	17.39	deleterious	0.55	0.65	0.36	neutral	0.47	neutral	0.4	neutral	0.47	neutral	1	0.99	deleterious	0.08	neutral	-2	neutral	0.68	deleterious	-2.65	low_impact	-0.15	medium_impact	0.46	medium_impact	0.38	0.9	15.49	18.25	0.45	N	0.91	polymorphism	1	0.05	rs200047468	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6145	6145	G	T	MI.2400	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	242	81	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	0.35	deleterious	-8.65	high_impact	3.6	0.67	neutral	0.04	damaging	4.12	23.80	deleterious	0.21	0.55	0.21	neutral	0.9	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.21	0.9	2.92	6.8	0.49	N	0.95	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14583	14583	C	A	MI.24000	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	91	31	V	L	Gta/Tta	0.41	0	0	benign	0.37	neutral	0.81	neutral	2.54	neutral	-1.57	neutral	-0.99	low_impact	1.9	0.56	damaging	0.48	neutral	2.12	16.96	deleterious	0.41	0.5	0.31	neutral	0.51	disease	0.49	neutral	0.54	disease	1	0.26	neutral	0.72	deleterious	-6	neutral	0.38	neutral	-0.58	medium_impact	0.56	medium_impact	0.45	medium_impact	0.78	0.85	28.32	22.32	0.35	N	0.59	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14583	14583	C	G	MI.24001	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	91	31	V	L	Gta/Cta	0.41	0	0	benign	0.37	neutral	0.81	neutral	2.54	neutral	-1.57	neutral	-0.99	low_impact	1.9	0.56	damaging	0.48	neutral	1.89	15.53	deleterious	0.41	0.5	0.31	neutral	0.51	disease	0.49	neutral	0.54	disease	1	0.26	neutral	0.72	deleterious	-6	neutral	0.38	neutral	-0.58	medium_impact	0.56	medium_impact	0.45	medium_impact	0.78	0.85	28.32	22.32	0.32	N	0.59	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14583	14583	C	T	MI.24002	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	91	31	V	M	Gta/Ata	0.41	0	0	probably_damaging	0.94	neutral	0.26	neutral	2.27	deleterious	-3.2	neutral	-0.24	medium_impact	2.25	0.74	neutral	0.53	neutral	3.68	23.30	deleterious	0.44	0.55	0.5	neutral	0.52	disease	0.53	disease	0.61	disease	2	0.95	neutral	0.16	neutral	1	deleterious	0.72	deleterious	-1.89	low_impact	-0.05	medium_impact	0.75	medium_impact	0.81	0.85	28.32	22.32	0.44	N	0.60	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14584	14584	T	A	MI.24003	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	90	30	L	F	ttA/ttT	-0.27	0	0	probably_damaging	0.98	neutral	0.41	neutral	1.98	neutral	-1.92	neutral	-2.14	low_impact	1.9	0.83	neutral	0.83	neutral	2.63	20.40	deleterious	0.43	0.55	0.2	neutral	0.53	disease	0.43	neutral	0.46	neutral	1	0.98	neutral	0.22	neutral	-2	neutral	0.69	deleterious	-2.35	low_impact	0.12	medium_impact	0.45	medium_impact	0.68	0.85	17.7	14.1	0.31	N	0.95	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14584	14584	T	G	MI.24004	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	90	30	L	F	ttA/ttC	-0.27	0	0	probably_damaging	0.98	neutral	0.41	neutral	1.98	neutral	-1.92	neutral	-2.14	low_impact	1.9	0.83	neutral	0.83	neutral	2.39	18.73	deleterious	0.43	0.55	0.2	neutral	0.53	disease	0.43	neutral	0.46	neutral	1	0.98	neutral	0.22	neutral	-2	neutral	0.69	deleterious	-2.35	low_impact	0.12	medium_impact	0.45	medium_impact	0.68	0.85	17.7	14.1	0.32	N	0.95	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14585	14585	A	C	MI.24005	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	89	30	L	W	tTa/tGa	-11.28	0	0	probably_damaging	1	deleterious	0.04	neutral	1.89	deleterious	-6.94	deleterious	-3.99	medium_impact	3.39	0.39	damaging	0.08	damaging	3.23	22.80	deleterious	0.15	0.4	0.85	disease	0.82	disease	0.64	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-3.55	low_impact	-0.56	medium_impact	1.7	medium_impact	0.68	0.85	17.7	14.1	0.38	N	0.98	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14585	14585	A	G	MI.24006	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	89	30	L	S	tTa/tCa	-11.28	0	0	probably_damaging	0.98	neutral	0.15	neutral	1.94	deleterious	-5.23	deleterious	-4.45	high_impact	3.73	0.39	damaging	0.1	damaging	3.68	23.30	deleterious	0.22	0.45	0.72	disease	0.86	disease	0.7	disease	0.77	disease	5	0.99	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-2.35	low_impact	-0.21	medium_impact	1.99	medium_impact	0.64	0.8	17.7	14.1	0.38	N	0.97	NA	NA	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14586	14586	A	C	MI.24007	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	88	30	L	V	Tta/Gta	3.63	0.09	0	benign	0.36	neutral	0.32	neutral	2.19	deleterious	-3.92	neutral	-0.97	low_impact	1.56	0.8	neutral	0.78	neutral	1.42	12.90	neutral	0.35	0.5	0.27	neutral	0.51	disease	0.41	neutral	0.47	neutral	1	0.62	neutral	0.48	deleterious	-6	neutral	0.48	deleterious	-0.57	medium_impact	0.03	medium_impact	0.17	medium_impact	0.77	0.85	17.7	14.1	0.44	N	0.71	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14586	14586	A	T	MI.24008	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	88	30	L	M	Tta/Ata	3.63	0.09	0	probably_damaging	0.98	neutral	0.12	neutral	1.96	deleterious	-4.61	neutral	-0.93	medium_impact	3.04	0.82	neutral	0.77	neutral	2.79	21.30	deleterious	0.36	0.5	0.45	neutral	0.6	disease	0.46	neutral	0.48	neutral	0	0.99	deleterious	0.07	neutral	1	deleterious	0.73	deleterious	-2.35	low_impact	-0.27	medium_impact	1.41	medium_impact	0.76	0.85	17.7	14.1	0.42	N	0.87	NA	NA	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14588	14588	C	T	MI.24009	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	86	29	G	D	gGt/gAt	-6.24	0	0	probably_damaging	1	neutral	0.2	neutral	2.16	deleterious	-4.54	deleterious	-6.96	high_impact	3.58	0.68	neutral	0.04	damaging	3.87	23.50	deleterious	0.15	0.4	0.61	disease	0.86	disease	0.72	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	-0.13	medium_impact	1.86	medium_impact	0.65	0.8	17.26	17.02	0.31	N	0.96	NA	NA	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6145	6145	G	C	MI.2401	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	242	81	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-1.66	deleterious	-9.34	high_impact	4.96	0.62	neutral	0.05	damaging	3.89	23.50	deleterious	0.23	0.55	0.4	neutral	0.93	disease	0.71	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.20	0.9	2.92	6.8	0.59	P	0.89	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14588	14588	C	A	MI.24010	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	86	29	G	V	gGt/gTt	-6.24	0	0	probably_damaging	1	neutral	0.69	neutral	2.39	neutral	0.54	deleterious	-8.95	low_impact	1.92	0.66	neutral	0.25	damaging	4.20	23.90	deleterious	0.25	0.45	0.18	neutral	0.67	disease	0.43	neutral	0.48	neutral	0	1	deleterious	0.35	neutral	-2	neutral	0.73	deleterious	-3.55	low_impact	0.4	medium_impact	0.47	medium_impact	0.80	0.85	17.26	17.02	0.26	N	0.98	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14588	14588	C	G	MI.24011	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	86	29	G	A	gGt/gCt	-6.24	0	0	probably_damaging	1	neutral	0.79	neutral	2.32	neutral	0.01	deleterious	-5.96	low_impact	1.17	0.69	neutral	0.41	neutral	3.23	22.80	deleterious	0.4	0.5	0.15	neutral	0.2	neutral	0.3	neutral	0.36	neutral	3	1	deleterious	0.4	neutral	-2	neutral	0.68	deleterious	-3.55	low_impact	0.53	medium_impact	-0.16	medium_impact	0.89	0.9	17.26	17.02	0.23	N	0.78	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14589	14589	C	A	MI.24012	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	85	29	G	C	Ggt/Tgt	2.48	0.76	0	probably_damaging	1	neutral	0.18	neutral	2.18	neutral	-2.49	deleterious	-8.95	high_impact	3.58	0.71	neutral	0.03	damaging	4.55	24.30	deleterious	0.19	0.45	0.67	disease	0.84	disease	0.63	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	-0.16	medium_impact	1.86	medium_impact	0.84	0.9	17.26	17.02	0.36	N	0.97	NA	NA	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14589	14589	C	T	MI.24013	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	85	29	G	S	Ggt/Agt	2.48	0.76	0	probably_damaging	1	neutral	0.42	neutral	2.27	neutral	-0.52	deleterious	-5.96	medium_impact	2.77	0.69	neutral	0.08	damaging	4.24	23.90	deleterious	0.41	0.5	0.32	neutral	0.7	disease	0.51	disease	0.58	disease	2	1	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	0.13	medium_impact	1.18	medium_impact	0.85	0.9	17.26	17.02	0.28	N	1.00	NA	NA	0.56	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14589	14589	C	G	MI.24014	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	85	29	G	R	Ggt/Cgt	2.48	0.76	0	probably_damaging	1	neutral	0.33	neutral	2.16	deleterious	-3.4	deleterious	-7.95	high_impact	3.58	0.67	neutral	0.03	damaging	4.05	23.70	deleterious	0.13	0.4	0.59	disease	0.84	disease	0.74	disease	0.82	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	0.04	medium_impact	1.86	medium_impact	0.77	0.85	17.26	17.02	0.43	N	1.00	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14591	14591	C	T	MI.24015	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	83	28	G	E	gGg/gAg	-14.5	0	0	probably_damaging	1	neutral	0.26	neutral	2.29	deleterious	-4.2	deleterious	-7.95	high_impact	3.75	0.64	neutral	0.07	damaging	4.03	23.70	deleterious	0.22	0.45	0.66	disease	0.91	disease	0.79	disease	0.86	disease	7	1	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	-0.05	medium_impact	2	high_impact	0.81	0.85	31.86	20.94	0.41	N	1.00	NA	NA	0.76	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14591	14591	C	A	MI.24016	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	83	28	G	V	gGg/gTg	-14.5	0	0	probably_damaging	1	neutral	0.52	neutral	2.37	deleterious	-4.01	deleterious	-8.95	medium_impact	3.4	0.61	neutral	0.06	damaging	4.07	23.70	deleterious	0.19	0.45	0.62	disease	0.91	disease	0.72	disease	0.81	disease	6	1	deleterious	0.26	neutral	1	deleterious	0.88	deleterious	-3.55	low_impact	0.23	medium_impact	1.71	medium_impact	0.86	0.9	31.86	20.94	0.31	N	0.98	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14591	14591	C	G	MI.24017	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	83	28	G	A	gGg/gCg	-14.5	0	0	probably_damaging	1	neutral	0.63	neutral	2.42	neutral	-0.24	deleterious	-5.96	low_impact	1.17	0.63	neutral	0.42	neutral	3.15	22.60	deleterious	0.38	0.5	0.19	neutral	0.24	neutral	0.39	neutral	0.42	neutral	2	1	deleterious	0.32	neutral	-2	neutral	0.70	deleterious	-3.55	low_impact	0.34	medium_impact	-0.16	medium_impact	0.86	0.9	31.86	20.94	0.34	N	0.78	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14592	14592	C	A	MI.24018	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	82	28	G	W	Ggg/Tgg	1.56	0.96	0	probably_damaging	1	neutral	0.18	neutral	2.27	deleterious	-7.77	deleterious	-7.96	high_impact	3.75	0.67	neutral	0.04	damaging	4.76	24.70	deleterious	0.17	0.45	0.94	disease	0.91	disease	0.75	disease	0.87	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	-0.16	medium_impact	2	high_impact	0.69	0.85	31.86	20.94	0.48	N	1.00	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14592	14592	C	G	MI.24019	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	82	28	G	R	Ggg/Cgg	1.56	0.96	0	probably_damaging	1	neutral	0.33	neutral	2.44	deleterious	-4.69	deleterious	-7.95	high_impact	3.75	0.63	neutral	0.04	damaging	4.01	23.60	deleterious	0.15	0.45	0.73	disease	0.91	disease	0.8	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.04	medium_impact	2	high_impact	0.81	0.85	31.86	20.94	0.51	N	1.00	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6146	6146	A	C	MI.2402	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	243	81	W	C	tgA/tgC	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.98	deleterious	-8.68	high_impact	4.96	0.56	damaging	0.04	damaging	3.91	23.50	deleterious	0.26	0.55	0.62	disease	0.93	disease	0.75	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.31	0.9	2.92	6.8	0.63	P	0.88	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14594	14594	T	A	MI.24020	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	80	27	Y	F	tAt/tTt	1.33	1	0	probably_damaging	1	neutral	1	neutral	2.25	neutral	-1.17	deleterious	-3.98	low_impact	1.49	0.77	neutral	0.66	neutral	2.41	18.89	deleterious	0.47	0.55	0.26	neutral	0.21	neutral	0.41	neutral	0.33	neutral	3	1	deleterious	0.5	deleterious	-2	neutral	0.71	deleterious	-3.55	low_impact	1.87	high_impact	0.11	medium_impact	0.69	0.85	48.23	8.81	0.43	N	0.80	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14594	14594	T	C	MI.24021	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	80	27	Y	C	tAt/tGt	1.33	1	0	probably_damaging	1	neutral	0.08	neutral	2.17	deleterious	-6.27	deleterious	-8.95	medium_impact	3.44	0.69	neutral	0.05	damaging	3.21	22.70	deleterious	0.34	0.5	0.91	disease	0.9	disease	0.73	disease	0.84	disease	7	1	deleterious	0.04	neutral	1	deleterious	0.89	deleterious	-3.55	low_impact	-0.38	medium_impact	1.74	medium_impact	0.43	0.8	48.23	8.81	0.47	N	1.00	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14594	14594	T	G	MI.24022	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	80	27	Y	S	tAt/tCt	1.33	1	0	probably_damaging	1	neutral	0.3	neutral	2.28	deleterious	-3.53	deleterious	-8.94	high_impact	3.78	0.67	neutral	0.06	damaging	3.80	23.40	deleterious	0.33	0.5	0.79	disease	0.85	disease	0.68	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0	medium_impact	2.03	high_impact	0.44	0.8	48.23	8.81	0.49	N	0.96	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14595	14595	A	T	MI.24023	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	79	27	Y	N	Tat/Aat	1.56	1	0	probably_damaging	1	neutral	0.23	neutral	2.24	deleterious	-5.14	deleterious	-8.94	high_impact	3.78	0.65	neutral	0.09	damaging	3.30	22.90	deleterious	0.34	0.5	0.81	disease	0.86	disease	0.7	disease	0.79	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.09	medium_impact	2.03	high_impact	0.46	0.8	48.23	8.81	0.49	N	1.00	NA	NA	0.81	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14595	14595	A	G	MI.24024	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	79	27	Y	H	Tat/Cat	1.56	1	0	probably_damaging	1	neutral	0.31	neutral	2.21	deleterious	-4.48	deleterious	-4.97	high_impact	3.78	0.65	neutral	0.05	damaging	3.26	22.80	deleterious	0.48	0.55	0.67	disease	0.81	disease	0.77	disease	0.79	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	0.01	medium_impact	2.03	high_impact	0.68	0.85	48.23	8.81	0.53	N	0.98	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14595	14595	A	C	MI.24025	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	79	27	Y	D	Tat/Gat	1.56	1	0	probably_damaging	1	neutral	0.09	neutral	2.18	deleterious	-5.84	deleterious	-9.94	high_impact	3.78	0.7	neutral	0.05	damaging	3.27	22.80	deleterious	0.2	0.45	0.89	disease	0.91	disease	0.77	disease	0.87	disease	7	1	deleterious	0.05	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	-0.35	medium_impact	2.03	high_impact	0.55	0.8	48.23	8.81	0.53	N	0.97	NA	NA	0.77	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14596	14596	A	T	MI.24026	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	78	26	I	M	atT/atA	3.63	1	0	probably_damaging	1	neutral	0.26	neutral	2.1	neutral	-1.66	deleterious	-2.79	medium_impact	3.1	0.25	damaging	0.2	damaging	2.99	22.20	deleterious	0.55	0.6	0.47	neutral	0.62	disease	0.57	disease	0.72	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	-0.05	medium_impact	1.46	medium_impact	0.81	0.85	15.49	8.03	0.95	P	0.87	NA	NA	0.58	rs387906424	Pathogenic	Leber's_optic_atrophy|Leber_hereditary_optic_neuropathy_with_dystonia	24729	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003|MedGen:C1839040,OMIM:500001	.	.	.	.	A14596T	LHON	+	-	Reported	4	P	P	P	damaging
chrM	14596	14596	A	C	MI.24027	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	78	26	I	M	atT/atG	3.63	1	0	probably_damaging	1	neutral	0.26	neutral	2.1	neutral	-1.66	deleterious	-2.79	medium_impact	3.1	0.25	damaging	0.2	damaging	2.88	21.80	deleterious	0.55	0.6	0.47	neutral	0.62	disease	0.57	disease	0.72	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	-0.05	medium_impact	1.46	medium_impact	0.81	0.85	15.49	8.03	0.94	P	0.87	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14597	14597	A	C	MI.24028	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	77	26	I	S	aTt/aGt	1.1	0.88	0	probably_damaging	1	neutral	0.37	neutral	2.04	neutral	-2.97	deleterious	-5.76	medium_impact	3.44	0.36	damaging	0.32	neutral	3.61	23.20	deleterious	0.39	0.5	0.52	disease	0.86	disease	0.62	disease	0.8	disease	6	1	deleterious	0.19	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	0.08	medium_impact	1.74	medium_impact	0.56	0.8	15.49	8.03	0.64	P	0.97	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14597	14597	A	T	MI.24029	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	77	26	I	N	aTt/aAt	1.1	0.88	0	probably_damaging	1	neutral	0.25	neutral	2	deleterious	-4.74	deleterious	-6.75	medium_impact	3.1	0.39	damaging	0.36	neutral	3.70	23.30	deleterious	0.43	0.55	0.66	disease	0.88	disease	0.65	disease	0.8	disease	6	1	deleterious	0.13	neutral	1	deleterious	0.84	deleterious	-3.55	low_impact	-0.06	medium_impact	1.46	medium_impact	0.59	0.8	15.49	8.03	0.58	P	0.99	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6146	6146	A	T	MI.2403	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	243	81	W	C	tgA/tgT	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.98	deleterious	-8.68	high_impact	4.96	0.56	damaging	0.04	damaging	4.04	23.70	deleterious	0.26	0.55	0.62	disease	0.93	disease	0.75	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.31	0.9	2.92	6.8	0.63	P	0.88	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14597	14597	A	G	MI.24030	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	77	26	I	T	aTt/aCt	1.1	0.88	0	probably_damaging	1	neutral	0.3	neutral	2.04	neutral	-2.89	deleterious	-4.58	medium_impact	3.44	0.35	damaging	0.33	neutral	3.08	22.50	deleterious	0.45	0.55	0.48	neutral	0.67	disease	0.62	disease	0.72	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	0	medium_impact	1.74	medium_impact	0.61	0.8	15.49	8.03	0.67	P	0.92	NA	NA	0.62	rs797045055	Likely_pathogenic	Dysarthria|Dystonia	205801	Human_Phenotype_Ontology:HP:0001260,MedGen:C0013362|Human_Phenotype_Ontology:HP:0001332,MedGen:C0013421	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	14598	14598	T	G	MI.24031	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	76	26	I	L	Att/Ctt	1.56	0.8	0	probably_damaging	1	neutral	0.61	neutral	2.21	neutral	-0.63	neutral	-1.99	medium_impact	3.1	0.41	damaging	0.37	neutral	2.35	18.50	deleterious	0.39	0.5	0.24	neutral	0.64	disease	0.58	disease	0.72	disease	4	0.99	deleterious	0.31	neutral	1	deleterious	0.70	deleterious	-3.55	low_impact	0.31	medium_impact	1.46	medium_impact	0.68	0.85	15.49	8.03	0.65	P	0.62	NA	NA	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14598	14598	T	C	MI.24032	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	76	26	I	V	Att/Gtt	1.56	0.8	0	probably_damaging	1	neutral	0.45	neutral	2.37	neutral	0.22	neutral	-0.62	low_impact	1.71	0.79	neutral	0.84	neutral	-0.45	0.29	neutral	0.58	0.65	0.29	neutral	0.49	neutral	0.41	neutral	0.45	neutral	1	0.99	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-3.55	low_impact	0.16	medium_impact	0.29	medium_impact	0.63	0.8	15.49	8.03	0.31	N	0.15	NA	NA	0.22	rs1057518882	Likely_pathogenic	Blindness|Parkinsonism	361108	Human_Phenotype_Ontology:HP:0000618,MedGen:C0456909|Human_Phenotype_Ontology:HP:0001300,MedGen:C0242422,Orphanet:ORPHA68402	.	COSM6716806	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	14598	14598	T	A	MI.24033	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	76	26	I	F	Att/Ttt	1.56	0.8	0	probably_damaging	1	neutral	0.59	neutral	2.1	neutral	-1.7	deleterious	-3.97	medium_impact	1.94	0.62	neutral	0.67	neutral	4.16	23.80	deleterious	0.51	0.6	0.15	neutral	0.79	disease	0.42	neutral	0.58	disease	2	1	deleterious	0.3	neutral	1	deleterious	0.70	deleterious	-3.55	low_impact	0.29	medium_impact	0.49	medium_impact	0.78	0.85	15.49	8.03	0.31	N	0.93	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14600	14600	G	T	MI.24034	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	74	25	P	H	cCt/cAt	-0.96	0	0	probably_damaging	1	neutral	0.54	neutral	1.43	deleterious	-8.49	deleterious	-8.93	high_impact	4	0.51	damaging	0.05	damaging	3.37	22.90	deleterious	0.24	0.45	0.93	disease	0.95	disease	0.76	disease	0.85	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.93	deleterious	-3.55	low_impact	0.25	medium_impact	2.21	high_impact	0.64	0.8	10.18	13.06	0.4	N	0.73	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14600	14600	G	A	MI.24035	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	74	25	P	L	cCt/cTt	-0.96	0	0	probably_damaging	1	neutral	0.75	neutral	1.53	deleterious	-7.25	deleterious	-9.92	high_impact	4	0.53	damaging	0.07	damaging	3.97	23.60	deleterious	0.32	0.5	0.86	disease	0.95	disease	0.7	disease	0.84	disease	7	1	deleterious	0.38	neutral	2	deleterious	0.91	deleterious	-3.55	low_impact	0.47	medium_impact	2.21	high_impact	0.74	0.85	10.18	13.06	0.38	N	0.96	NA	NA	0.82	.	.	.	.	.	.	.	.	.	G14600A	Leigh Disease w/optic atrophy	+	+	Reported	3	.	P	P	damaging
chrM	14600	14600	G	C	MI.24036	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	74	25	P	R	cCt/cGt	-0.96	0	0	probably_damaging	1	neutral	0.35	neutral	1.44	deleterious	-7.4	deleterious	-8.93	high_impact	4	0.44	damaging	0.06	damaging	3.15	22.60	deleterious	0.22	0.45	0.87	disease	0.96	disease	0.78	disease	0.9	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.55	low_impact	0.06	medium_impact	2.21	high_impact	0.56	0.8	10.18	13.06	0.47	N	0.66	NA	NA	0.85	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14601	14601	G	A	MI.24037	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	73	25	P	S	Cct/Tct	2.25	0.98	0	probably_damaging	1	neutral	0.56	neutral	1.47	deleterious	-6.43	deleterious	-7.93	high_impact	4	0.5	damaging	0.08	damaging	3.44	23.00	deleterious	0.3	0.45	0.78	disease	0.94	disease	0.66	disease	0.8	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.27	medium_impact	2.21	high_impact	0.44	0.8	10.18	13.06	0.54	P	0.79	NA	NA	0.78	.	.	.	.	.	.	COSM1138279	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14601	14601	G	T	MI.24038	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	73	25	P	T	Cct/Act	2.25	0.98	0	probably_damaging	1	neutral	0.39	neutral	1.49	deleterious	-6.87	deleterious	-7.93	high_impact	4	0.53	damaging	0.07	damaging	3.08	22.50	deleterious	0.26	0.45	0.82	disease	0.93	disease	0.73	disease	0.82	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.1	medium_impact	2.21	high_impact	0.71	0.85	10.18	13.06	0.54	P	0.88	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14601	14601	G	C	MI.24039	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	73	25	P	A	Cct/Gct	2.25	0.98	0	probably_damaging	1	neutral	0.52	neutral	1.49	deleterious	-6.16	deleterious	-7.93	high_impact	3.66	0.54	damaging	0.09	damaging	2.66	20.60	deleterious	0.23	0.45	0.75	disease	0.89	disease	0.73	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	0.23	medium_impact	1.93	medium_impact	0.73	0.85	10.18	13.06	0.5	N	0.71	NA	NA	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6147	6147	C	G	MI.2404	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	244	82	L	V	Cta/Gta	0.59	0.04	0	probably_damaging	0.98	deleterious	0	neutral	2.53	neutral	-1.42	neutral	-1.98	medium_impact	3.48	0.42	damaging	0.11	damaging	3.35	22.90	deleterious	0.33	0.55	0.31	neutral	0.82	disease	0.5	neutral	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-2.35	low_impact	-1.48	low_impact	2.11	high_impact	0.75	0.9	1.36	7.02	0.44	N	0.66	polymorphism	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14603	14603	G	C	MI.24040	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	71	24	S	C	tCt/tGt	-4.17	0	0	probably_damaging	1	neutral	0.18	neutral	2.08	deleterious	-5.77	deleterious	-4.98	high_impact	3.94	0.64	neutral	0.02	damaging	3.18	22.70	deleterious	0.38	0.5	0.75	disease	0.91	disease	0.75	disease	0.83	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	-0.16	medium_impact	2.16	high_impact	0.70	0.85	18.14	17.22	0.32	N	0.99	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14603	14603	G	A	MI.24041	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	71	24	S	F	tCt/tTt	-4.17	0	0	probably_damaging	1	neutral	0.71	neutral	2.09	deleterious	-6.13	deleterious	-5.97	high_impact	3.6	0.66	neutral	0.03	damaging	3.78	23.40	deleterious	0.28	0.45	0.82	disease	0.95	disease	0.77	disease	0.9	disease	8	1	deleterious	0.36	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	0.42	medium_impact	1.88	medium_impact	0.49	0.8	18.14	17.22	0.32	N	0.98	NA	NA	0.80	.	.	.	.	.	pancreatic cancer cell line xenograft	COSM1155564	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14603	14603	G	T	MI.24042	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	71	24	S	Y	tCt/tAt	-4.17	0	0	probably_damaging	1	neutral	1	neutral	2.1	deleterious	-6.34	deleterious	-5.97	high_impact	3.94	0.62	neutral	0.02	damaging	3.50	23.10	deleterious	0.28	0.45	0.84	disease	0.95	disease	0.78	disease	0.9	disease	8	1	deleterious	0.5	deleterious	2	deleterious	0.90	deleterious	-3.55	low_impact	1.87	high_impact	2.16	high_impact	0.59	0.8	18.14	17.22	0.35	N	0.98	NA	NA	0.80	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14604	14604	A	T	MI.24043	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	70	24	S	T	Tct/Act	2.25	0.1	0	probably_damaging	1	neutral	0.39	neutral	2.16	deleterious	-3.64	deleterious	-2.98	medium_impact	3.25	0.68	neutral	0.25	damaging	3.11	22.50	deleterious	0.33	0.5	0.46	neutral	0.82	disease	0.73	disease	0.68	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	0.1	medium_impact	1.58	medium_impact	0.81	0.85	18.14	17.22	0.38	N	0.69	NA	NA	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14604	14604	A	G	MI.24044	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	70	24	S	P	Tct/Cct	2.25	0.1	0	probably_damaging	1	neutral	0.22	neutral	2.1	deleterious	-5.1	deleterious	-4.98	high_impact	3.94	0.63	neutral	0.04	damaging	3.82	23.40	deleterious	0.24	0.45	0.67	disease	0.94	disease	0.75	disease	0.9	disease	8	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.55	low_impact	-0.1	medium_impact	2.16	high_impact	0.64	0.8	18.14	17.22	0.43	N	0.98	NA	NA	0.82	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14604	14604	A	C	MI.24045	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	70	24	S	A	Tct/Gct	2.25	0.1	0	probably_damaging	1	neutral	0.52	neutral	2.15	neutral	-2.06	deleterious	-2.98	medium_impact	2.26	0.69	neutral	0.2	damaging	3.06	22.40	deleterious	0.37	0.5	0.19	neutral	0.63	disease	0.62	disease	0.43	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	0.23	medium_impact	0.75	medium_impact	0.70	0.85	18.14	17.22	0.3	N	0.48	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14606	14606	G	A	MI.24046	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	68	23	P	L	cCt/cTt	-9.22	0	0	probably_damaging	1	neutral	0.76	neutral	2.45	neutral	-2.81	deleterious	-9.98	medium_impact	3.29	0.61	neutral	0.04	damaging	4.02	23.60	deleterious	0.39	0.5	0.86	disease	0.94	disease	0.68	disease	0.81	disease	6	1	deleterious	0.38	neutral	1	deleterious	0.89	deleterious	-3.55	low_impact	0.48	medium_impact	1.62	medium_impact	0.93	0.95	19.03	10.37	0.23	N	0.96	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14606	14606	G	T	MI.24047	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	68	23	P	H	cCt/cAt	-9.22	0	0	probably_damaging	1	neutral	0.48	neutral	2.31	deleterious	-5.68	deleterious	-8.98	high_impact	3.98	0.65	neutral	0.02	damaging	3.40	23.00	deleterious	0.4	0.5	0.93	disease	0.94	disease	0.75	disease	0.84	disease	7	1	deleterious	0.24	neutral	2	deleterious	0.90	deleterious	-3.55	low_impact	0.19	medium_impact	2.19	high_impact	0.71	0.85	19.03	10.37	0.35	N	0.73	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14606	14606	G	C	MI.24048	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	68	23	P	R	cCt/cGt	-9.22	0	0	probably_damaging	1	neutral	0.28	neutral	2.41	deleterious	-4.48	deleterious	-8.98	medium_impact	3.44	0.63	neutral	0.03	damaging	3.22	22.70	deleterious	0.39	0.5	0.87	disease	0.95	disease	0.74	disease	0.85	disease	7	1	deleterious	0.14	neutral	1	deleterious	0.90	deleterious	-3.55	low_impact	-0.02	medium_impact	1.74	medium_impact	0.77	0.85	19.03	10.37	0.36	N	0.66	NA	NA	0.78	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14607	14607	G	C	MI.24049	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	67	23	P	A	Cct/Gct	5	1	0	probably_damaging	1	neutral	0.47	neutral	2.32	deleterious	-3.5	deleterious	-7.99	high_impact	3.98	0.66	neutral	0.05	damaging	2.61	20.30	deleterious	0.37	0.5	0.75	disease	0.86	disease	0.72	disease	0.76	disease	5	1	deleterious	0.24	neutral	2	deleterious	0.86	deleterious	-3.55	low_impact	0.18	medium_impact	2.19	high_impact	0.79	0.85	19.03	10.37	0.59	P	0.71	NA	NA	0.84	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6147	6147	C	A	MI.2405	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	244	82	L	M	Cta/Ata	0.59	0.04	0	probably_damaging	1	neutral	0.21	neutral	2.42	neutral	-2.55	neutral	-1.24	medium_impact	2.29	0.58	damaging	0.14	damaging	3.61	23.20	deleterious	0.29	0.55	0.59	disease	0.61	disease	0.18	neutral	0.46	neutral	1	1	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-3.58	low_impact	-0.13	medium_impact	1.02	medium_impact	0.74	0.9	1.36	7.02	0.44	N	0.59	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14607	14607	G	A	MI.24050	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	67	23	P	S	Cct/Tct	5	1	0	probably_damaging	1	neutral	0.48	neutral	2.4	deleterious	-3.78	deleterious	-7.99	medium_impact	3.29	0.66	neutral	0.05	damaging	3.50	23.10	deleterious	0.4	0.5	0.78	disease	0.91	disease	0.68	disease	0.72	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.87	deleterious	-3.55	low_impact	0.19	medium_impact	1.62	medium_impact	0.28	0.8	19.03	10.37	0.51	N	0.79	NA	NA	0.69	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14607	14607	G	T	MI.24051	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	67	23	P	T	Cct/Act	5	1	0	probably_damaging	1	neutral	0.35	neutral	2.34	deleterious	-4.09	deleterious	-7.99	high_impact	3.98	0.65	neutral	0.03	damaging	3.07	22.40	deleterious	0.37	0.5	0.82	disease	0.91	disease	0.71	disease	0.79	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.55	low_impact	0.06	medium_impact	2.19	high_impact	0.78	0.85	19.03	10.37	0.6	P	0.88	NA	NA	0.83	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14608	14608	C	A	MI.24052	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	66	22	K	N	aaG/aaT	2.71	1	0	probably_damaging	1	neutral	0.58	neutral	2.49	neutral	-0.07	deleterious	-4.99	low_impact	1.12	0.71	neutral	0.44	neutral	4.31	24.00	deleterious	0.63	0.7	0.14	neutral	0.29	neutral	0.47	neutral	0.4	neutral	2	1	deleterious	0.29	neutral	-2	neutral	0.69	deleterious	-3.55	low_impact	0.28	medium_impact	-0.2	medium_impact	0.68	0.85	25.22	20.33	0.44	N	0.67	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14608	14608	C	G	MI.24053	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	66	22	K	N	aaG/aaC	2.71	1	0	probably_damaging	1	neutral	0.58	neutral	2.49	neutral	-0.07	deleterious	-4.99	low_impact	1.12	0.71	neutral	0.44	neutral	4.08	23.70	deleterious	0.63	0.7	0.14	neutral	0.29	neutral	0.47	neutral	0.4	neutral	2	1	deleterious	0.29	neutral	-2	neutral	0.69	deleterious	-3.55	low_impact	0.28	medium_impact	-0.2	medium_impact	0.68	0.85	25.22	20.33	0.45	N	0.67	NA	NA	0.54	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14609	14609	T	A	MI.24054	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	65	22	K	M	aAg/aTg	-1.42	0	0	probably_damaging	1	neutral	0.28	neutral	2.19	deleterious	-4.11	deleterious	-5.99	high_impact	3.58	0.77	neutral	0.2	damaging	4.11	23.70	deleterious	0.3	0.45	0.72	disease	0.77	disease	0.74	disease	0.79	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	-0.02	medium_impact	1.86	medium_impact	0.49	0.8	25.22	20.33	0.3	N	0.43	NA	NA	0.64	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14609	14609	T	G	MI.24055	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	65	22	K	T	aAg/aCg	-1.42	0	0	probably_damaging	1	neutral	0.45	neutral	2.24	neutral	-2.26	deleterious	-5.99	high_impact	3.58	0.79	neutral	0.2	damaging	3.83	23.40	deleterious	0.26	0.45	0.46	neutral	0.76	disease	0.7	disease	0.76	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.82	deleterious	-3.55	low_impact	0.16	medium_impact	1.86	medium_impact	0.51	0.8	25.22	20.33	0.27	N	0.76	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14610	14610	T	G	MI.24056	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	64	22	K	Q	Aag/Cag	1.1	0.57	0	probably_damaging	1	neutral	0.31	neutral	2.24	neutral	-1.95	deleterious	-3.99	high_impact	3.58	0.78	neutral	0.2	damaging	3.62	23.20	deleterious	0.39	0.5	0.38	neutral	0.73	disease	0.72	disease	0.75	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.55	low_impact	0.01	medium_impact	1.86	medium_impact	0.69	0.85	25.22	20.33	0.32	N	0.86	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14610	14610	T	C	MI.24057	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	64	22	K	E	Aag/Gag	1.1	0.57	0	probably_damaging	1	neutral	0.27	neutral	2.27	neutral	-1.32	deleterious	-3.99	high_impact	3.58	0.75	neutral	0.19	damaging	3.76	23.30	deleterious	0.32	0.5	0.32	neutral	0.89	disease	0.76	disease	0.82	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.55	low_impact	-0.03	medium_impact	1.86	medium_impact	0.70	0.85	25.22	20.33	0.43	N	0.89	NA	NA	0.63	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14612	14612	G	T	MI.24058	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	62	21	S	Y	tCt/tAt	-4.17	0	0	probably_damaging	1	neutral	1	neutral	1.93	neutral	-1.54	deleterious	-4.68	high_impact	3.54	0.71	neutral	0.12	damaging	3.34	22.90	deleterious	0.23	0.45	0.67	disease	0.93	disease	0.68	disease	0.8	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.84	deleterious	-3.55	low_impact	1.87	high_impact	1.83	medium_impact	0.70	0.85	22.57	20.88	0.23	N	0.86	NA	NA	0.79	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14612	14612	G	A	MI.24059	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	62	21	S	F	tCt/tTt	-4.17	0	0	probably_damaging	1	neutral	0.72	neutral	1.96	neutral	0.53	deleterious	-4.57	high_impact	3.88	0.68	neutral	0.11	damaging	3.66	23.20	deleterious	0.28	0.45	0.63	disease	0.93	disease	0.68	disease	0.8	disease	6	1	deleterious	0.36	neutral	2	deleterious	0.83	deleterious	-3.55	low_impact	0.43	medium_impact	2.11	high_impact	0.50	0.8	22.57	20.88	0.22	N	0.83	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6148	6148	T	A	MI.2406	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	245	82	L	Q	cTa/cAa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.35	deleterious	-5.03	deleterious	-3.99	high_impact	5	0.51	damaging	0.08	damaging	4.28	24.00	deleterious	0.12	0.55	0.73	disease	0.87	disease	0.52	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.70	0.9	1.36	7.02	0.59	P	0.82	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14612	14612	G	C	MI.24060	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	62	21	S	C	tCt/tGt	-4.17	0	0	probably_damaging	1	neutral	0.18	neutral	1.92	neutral	-2.34	deleterious	-3.82	medium_impact	2.79	0.84	neutral	0.34	neutral	1.11	11.26	neutral	0.4	0.5	0.7	disease	0.86	disease	0.52	disease	0.56	disease	1	1	deleterious	0.09	neutral	1	deleterious	0.81	deleterious	-3.55	low_impact	-0.16	medium_impact	1.2	medium_impact	0.76	0.85	22.57	20.88	0.31	N	0.55	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14613	14613	A	T	MI.24061	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	61	21	S	T	Tct/Act	1.1	0	0	probably_damaging	1	neutral	0.4	neutral	2	neutral	1.05	neutral	-2.15	medium_impact	3.19	0.82	neutral	0.77	neutral	1.65	14.15	neutral	0.28	0.45	0.23	neutral	0.81	disease	0.61	disease	0.66	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-3.55	low_impact	0.11	medium_impact	1.53	medium_impact	0.82	0.85	22.57	20.88	0.34	N	0.17	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14613	14613	A	C	MI.24062	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	61	21	S	A	Tct/Gct	1.1	0	0	probably_damaging	1	neutral	0.53	neutral	2.07	neutral	-0.64	neutral	-2.04	medium_impact	2.79	0.81	neutral	0.33	neutral	0.20	4.64	deleterious	0.37	0.5	0.3	neutral	0.77	disease	0.53	disease	0.55	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	0.24	medium_impact	1.2	medium_impact	0.73	0.85	22.57	20.88	0.22	N	0.20	NA	NA	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14613	14613	A	G	MI.24063	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	61	21	S	P	Tct/Cct	1.1	0	0	probably_damaging	1	neutral	0.24	neutral	1.92	deleterious	-3.5	deleterious	-4.13	high_impact	3.88	0.67	neutral	0.12	damaging	3.70	23.30	deleterious	0.25	0.45	0.61	disease	0.92	disease	0.65	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	-0.07	medium_impact	2.11	high_impact	0.73	0.85	22.57	20.88	0.33	N	0.83	NA	NA	0.75	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14615	14615	G	A	MI.24064	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	59	20	S	F	tCt/tTt	-0.96	0	0	probably_damaging	0.98	neutral	0.6	neutral	2.36	deleterious	-4.51	deleterious	-5.74	medium_impact	2.84	0.76	neutral	0.51	neutral	3.76	23.30	deleterious	0.25	0.45	0.77	disease	0.9	disease	0.75	disease	0.83	disease	7	0.98	neutral	0.31	neutral	1	deleterious	0.85	deleterious	-2.35	low_impact	0.3	medium_impact	1.24	medium_impact	0.65	0.8	24.78	23.03	0.28	N	0.98	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14615	14615	G	C	MI.24065	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	59	20	S	C	tCt/tGt	-0.96	0	0	benign	0.19	neutral	0.16	neutral	2.21	deleterious	-4.22	deleterious	-4.58	medium_impact	2.35	0.88	neutral	0.63	neutral	3.05	22.40	deleterious	0.25	0.45	0.69	disease	0.87	disease	0.68	disease	0.8	disease	6	0.81	neutral	0.49	deleterious	-3	neutral	0.46	deleterious	-0.22	medium_impact	-0.19	medium_impact	0.83	medium_impact	0.73	0.85	24.78	23.03	0.4	N	0.63	NA	NA	0.57	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14615	14615	G	T	MI.24066	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	59	20	S	Y	tCt/tAt	-0.96	0	0	probably_damaging	0.99	neutral	0.78	neutral	2.23	deleterious	-4.74	deleterious	-5.73	medium_impact	3.38	0.77	neutral	0.57	neutral	3.40	23.00	deleterious	0.23	0.45	0.8	disease	0.88	disease	0.76	disease	0.86	disease	7	0.98	deleterious	0.4	neutral	1	deleterious	0.86	deleterious	-2.63	low_impact	0.51	medium_impact	1.69	medium_impact	0.75	0.85	24.78	23.03	0.31	N	0.96	NA	NA	0.73	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14616	14616	A	C	MI.24067	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	58	20	S	A	Tct/Gct	3.4	0.46	0	possibly_damaging	0.67	neutral	1	neutral	2.27	neutral	0.94	deleterious	-2.57	neutral_impact	0.5	0.9	neutral	0.95	neutral	1.52	13.40	neutral	0.38	0.5	0.1	neutral	0.19	neutral	0.42	neutral	0.33	neutral	3	0.67	neutral	0.67	deleterious	-3	neutral	0.57	deleterious	-1.08	low_impact	1.87	high_impact	-0.72	medium_impact	0.81	0.85	24.78	23.03	0.36	N	0.14	NA	NA	0.52	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14616	14616	A	T	MI.24068	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	58	20	S	T	Tct/Act	3.4	0.46	0	possibly_damaging	0.86	neutral	0.35	neutral	2.43	neutral	-2.09	deleterious	-2.83	medium_impact	3.04	0.76	neutral	0.57	neutral	2.97	22.10	deleterious	0.27	0.45	0.39	neutral	0.67	disease	0.73	disease	0.75	disease	5	0.88	neutral	0.25	neutral	0	NA	0.74	deleterious	-1.52	low_impact	0.06	medium_impact	1.41	medium_impact	0.75	0.85	24.78	23.03	0.4	N	0.54	NA	NA	0.58	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14616	14616	A	G	MI.24069	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	58	20	S	P	Tct/Cct	3.4	0.46	0	probably_damaging	0.98	neutral	0.24	neutral	2.2	deleterious	-3.58	deleterious	-4.71	medium_impact	3.38	0.85	neutral	0.52	neutral	3.58	23.20	deleterious	0.21	0.45	0.61	disease	0.93	disease	0.73	disease	0.86	disease	7	0.99	deleterious	0.13	neutral	1	deleterious	0.87	deleterious	-2.35	low_impact	-0.07	medium_impact	1.69	medium_impact	0.78	0.85	24.78	23.03	0.35	N	0.94	NA	NA	0.72	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6148	6148	T	G	MI.2407	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	245	82	L	R	cTa/cGa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.35	deleterious	-4.87	deleterious	-4.01	high_impact	5	0.5	damaging	0.07	damaging	4.13	23.80	deleterious	0.1	0.55	0.71	disease	0.95	disease	0.66	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.44	0.9	1.36	7.02	0.58	P	0.90	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14617	14617	A	T	MI.24070	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	57	19	F	L	ttT/ttA	-0.04	0	0	probably_damaging	1	neutral	0.53	neutral	2.68	neutral	-2.82	deleterious	-4.12	medium_impact	2.07	0.86	neutral	0.83	neutral	2.79	21.30	deleterious	0.52	0.6	0.09	neutral	0.68	disease	0.44	neutral	0.55	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.69	deleterious	-3.55	low_impact	0.24	medium_impact	0.59	medium_impact	0.86	0.9	29.65	29.28	0.27	N	0.40	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14617	14617	A	C	MI.24071	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	57	19	F	L	ttT/ttG	-0.04	0	0	probably_damaging	1	neutral	0.53	neutral	2.68	neutral	-2.82	deleterious	-4.12	medium_impact	2.07	0.86	neutral	0.83	neutral	2.66	20.60	deleterious	0.52	0.6	0.09	neutral	0.68	disease	0.44	neutral	0.55	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.69	deleterious	-3.55	low_impact	0.24	medium_impact	0.59	medium_impact	0.86	0.9	29.65	29.28	0.27	N	0.40	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14618	14618	A	C	MI.24072	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	56	19	F	C	tTt/tGt	-0.96	0	0	probably_damaging	1	neutral	0.09	neutral	2.27	deleterious	-5.3	deleterious	-6.34	medium_impact	3.39	0.8	neutral	0.18	damaging	3.48	23.10	deleterious	0.31	0.5	0.65	disease	0.88	disease	0.66	disease	0.81	disease	6	1	deleterious	0.05	neutral	1	deleterious	0.83	deleterious	-3.55	low_impact	-0.35	medium_impact	1.7	medium_impact	0.46	0.8	29.65	29.28	0.32	N	0.81	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14618	14618	A	T	MI.24073	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	56	19	F	Y	tTt/tAt	-0.96	0	0	probably_damaging	1	neutral	0.51	neutral	2.27	deleterious	-3.08	neutral	-2.48	medium_impact	3.39	0.78	neutral	0.21	damaging	3.55	23.10	deleterious	0.31	0.45	0.53	disease	0.75	disease	0.65	disease	0.73	disease	5	1	deleterious	0.26	neutral	1	deleterious	0.80	deleterious	-3.55	low_impact	0.22	medium_impact	1.7	medium_impact	0.73	0.85	29.65	29.28	0.25	N	0.76	NA	NA	0.59	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14618	14618	A	G	MI.24074	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	56	19	F	S	tTt/tCt	-0.96	0	0	probably_damaging	1	neutral	0.36	neutral	2.29	neutral	-0.41	deleterious	-6.42	medium_impact	3.39	0.78	neutral	0.3	neutral	4.07	23.70	deleterious	0.3	0.45	0.51	disease	0.82	disease	0.62	disease	0.78	disease	6	1	deleterious	0.18	neutral	1	deleterious	0.82	deleterious	-3.55	low_impact	0.07	medium_impact	1.7	medium_impact	0.61	0.8	29.65	29.28	0.29	N	0.92	NA	NA	0.60	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14619	14619	A	T	MI.24075	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	55	19	F	I	Ttt/Att	2.48	0.05	0	probably_damaging	1	neutral	0.33	neutral	2.51	deleterious	-3.41	deleterious	-4.16	medium_impact	2.84	0.76	neutral	0.49	neutral	2.68	20.70	deleterious	0.34	0.5	0.15	neutral	0.74	disease	0.47	neutral	0.59	disease	2	1	deleterious	0.17	neutral	1	deleterious	0.71	deleterious	-3.55	low_impact	0.04	medium_impact	1.24	medium_impact	0.71	0.85	29.65	29.28	0.42	N	0.79	NA	NA	0.55	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14619	14619	A	C	MI.24076	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	55	19	F	V	Ttt/Gtt	2.48	0.05	0	probably_damaging	1	neutral	1	neutral	2.49	deleterious	-3.06	deleterious	-5	neutral_impact	0.49	0.84	neutral	0.9	neutral	2.03	16.38	deleterious	0.35	0.5	0.12	neutral	0.38	neutral	0.43	neutral	0.44	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.66	deleterious	-3.55	low_impact	1.87	high_impact	-0.73	medium_impact	0.73	0.85	29.65	29.28	0.29	N	0.81	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14619	14619	A	G	MI.24077	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	55	19	F	L	Ttt/Ctt	2.48	0.05	0	probably_damaging	1	neutral	0.53	neutral	2.68	neutral	-2.82	deleterious	-4.12	medium_impact	2.07	0.86	neutral	0.83	neutral	2.72	20.90	deleterious	0.52	0.6	0.09	neutral	0.68	disease	0.44	neutral	0.55	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.69	deleterious	-3.55	low_impact	0.24	medium_impact	0.59	medium_impact	0.86	0.9	29.65	29.28	0.31	N	0.40	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14621	14621	C	A	MI.24078	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	53	18	G	V	gGg/gTg	-11.97	0	0	probably_damaging	1	neutral	0.58	neutral	2.57	neutral	1.06	deleterious	-7.2	medium_impact	2.06	0.78	neutral	0.42	neutral	3.09	22.50	deleterious	0.36	0.5	0.24	neutral	0.85	disease	0.46	neutral	0.6	disease	2	1	deleterious	0.29	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	0.28	medium_impact	0.59	medium_impact	0.80	0.85	21.24	15.57	0.27	N	0.94	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14621	14621	C	T	MI.24079	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	53	18	G	E	gGg/gAg	-11.97	0	0	probably_damaging	1	neutral	0.27	neutral	2.32	neutral	-2.53	deleterious	-6.15	high_impact	3.6	0.76	neutral	0.15	damaging	3.94	23.50	deleterious	0.38	0.5	0.52	disease	0.85	disease	0.72	disease	0.8	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-3.55	low_impact	-0.03	medium_impact	1.88	medium_impact	0.87	0.9	21.24	15.57	0.31	N	0.95	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6148	6148	T	C	MI.2408	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	245	82	L	P	cTa/cCa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.34	deleterious	-5.43	deleterious	-4.7	high_impact	5	0.42	damaging	0.08	damaging	3.85	23.40	deleterious	0.12	0.55	0.78	disease	0.91	disease	0.65	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.70	0.9	1.36	7.02	0.54	P	0.83	disease_causing	0.58	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14621	14621	C	G	MI.24080	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	53	18	G	A	gGg/gCg	-11.97	0	0	probably_damaging	1	neutral	0.58	neutral	2.46	neutral	0.62	deleterious	-4.27	low_impact	1.34	0.81	neutral	0.81	neutral	1.98	16.10	deleterious	0.59	0.65	0.13	neutral	0.2	neutral	0.28	neutral	0.34	neutral	3	1	deleterious	0.29	neutral	-2	neutral	0.66	deleterious	-3.55	low_impact	0.28	medium_impact	-0.02	medium_impact	0.90	0.95	21.24	15.57	0.3	N	0.52	NA	NA	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14622	14622	C	A	MI.24081	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	52	18	G	W	Ggg/Tgg	0.18	0	0	probably_damaging	1	neutral	0.18	neutral	2.32	deleterious	-3.55	deleterious	-6.68	medium_impact	3.05	0.77	neutral	0.2	damaging	4.70	24.60	deleterious	0.26	0.45	0.88	disease	0.87	disease	0.68	disease	0.81	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.87	deleterious	-3.55	low_impact	-0.16	medium_impact	1.42	medium_impact	0.65	0.8	21.24	15.57	0.27	N	0.95	NA	NA	0.65	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14622	14622	C	G	MI.24082	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	52	18	G	R	Ggg/Cgg	0.18	0	0	probably_damaging	1	neutral	0.35	neutral	2.32	neutral	-1.72	deleterious	-6.31	high_impact	3.6	0.76	neutral	0.15	damaging	4.01	23.60	deleterious	0.3	0.45	0.58	disease	0.88	disease	0.73	disease	0.83	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.55	low_impact	0.06	medium_impact	1.88	medium_impact	0.89	0.9	21.24	15.57	0.31	N	0.98	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14624	14624	A	T	MI.24083	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	50	17	V	E	gTg/gAg	-20	0	0	probably_damaging	0.96	neutral	0.11	neutral	2.17	deleterious	-6.25	deleterious	-5.49	high_impact	3.6	0.8	neutral	0.37	neutral	4.18	23.80	deleterious	0.17	0.45	0.8	disease	0.77	disease	0.78	disease	0.83	disease	7	0.98	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-2.06	low_impact	-0.3	medium_impact	1.88	medium_impact	0.79	0.85	28.76	21.22	0.38	N	0.95	NA	NA	0.74	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14624	14624	A	C	MI.24084	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	50	17	V	G	gTg/gGg	-20	0	0	probably_damaging	0.94	neutral	0.22	neutral	2.24	deleterious	-6.33	deleterious	-6.46	high_impact	3.6	0.81	neutral	0.51	neutral	3.09	22.50	deleterious	0.23	0.45	0.81	disease	0.65	disease	0.67	disease	0.73	disease	5	0.96	neutral	0.14	neutral	2	deleterious	0.77	deleterious	-1.89	low_impact	-0.1	medium_impact	1.88	medium_impact	0.75	0.85	28.76	21.22	0.39	N	0.91	NA	NA	0.66	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14624	14624	A	G	MI.24085	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	50	17	V	A	gTg/gCg	-20	0	0	possibly_damaging	0.58	neutral	0.34	neutral	2.28	deleterious	-4.25	deleterious	-3.53	medium_impact	2.22	0.91	neutral	0.84	neutral	0.56	7.85	deleterious	0.48	0.55	0.51	disease	0.36	neutral	0.52	disease	0.47	neutral	1	0.67	neutral	0.38	neutral	0	NA	0.55	deleterious	-0.92	medium_impact	0.05	medium_impact	0.72	medium_impact	0.81	0.85	28.76	21.22	0.52	N	0.75	NA	NA	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14625	14625	C	G	MI.24086	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	49	17	V	L	Gtg/Ctg	3.17	0.17	0	possibly_damaging	0.45	neutral	1	neutral	2.66	neutral	-2.48	neutral	-1.62	low_impact	1.49	0.91	neutral	0.86	neutral	0.31	5.74	deleterious	0.47	0.55	0.17	neutral	0.27	neutral	0.42	neutral	0.44	neutral	1	0.45	neutral	0.78	deleterious	-3	neutral	0.28	neutral	-0.72	medium_impact	1.87	high_impact	0.11	medium_impact	0.90	0.95	28.76	21.22	0.34	N	0.50	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14625	14625	C	A	MI.24087	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	49	17	V	L	Gtg/Ttg	3.17	0.17	0	possibly_damaging	0.45	neutral	1	neutral	2.66	neutral	-2.48	neutral	-1.62	low_impact	1.49	0.91	neutral	0.86	neutral	0.67	8.66	deleterious	0.47	0.55	0.17	neutral	0.27	neutral	0.42	neutral	0.44	neutral	1	0.45	neutral	0.78	deleterious	-3	neutral	0.28	neutral	-0.72	medium_impact	1.87	high_impact	0.11	medium_impact	0.90	0.95	28.76	21.22	0.34	N	0.50	NA	NA	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14625	14625	C	T	MI.24088	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	49	17	V	M	Gtg/Atg	3.17	0.17	0	benign	0.33	neutral	0.38	neutral	2.27	neutral	-2.91	neutral	-1.82	medium_impact	1.98	0.88	neutral	0.8	neutral	0.83	9.63	deleterious	0.61	0.65	0.53	disease	0.36	neutral	0.43	neutral	0.42	neutral	2	0.55	neutral	0.53	deleterious	-3	neutral	0.31	neutral	-0.51	medium_impact	0.09	medium_impact	0.52	medium_impact	0.94	0.95	28.76	21.22	0.44	N	0.66	NA	NA	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14626	14626	A	C	MI.24089	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	48	16	F	L	ttT/ttG	-2.11	0	0	probably_damaging	1	neutral	1	neutral	2.4	neutral	1.1	deleterious	-5.2	low_impact	1.37	0.88	neutral	0.89	neutral	2.58	20.10	deleterious	0.44	0.55	0.11	neutral	0.16	neutral	0.32	neutral	0.24	neutral	5	1	deleterious	0.5	deleterious	-2	neutral	0.65	deleterious	-3.55	low_impact	1.87	high_impact	0.01	medium_impact	0.75	0.85	17.26	11.64	0.31	N	0.75	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6150	6150	G	A	MI.2409	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	247	83	V	I	Gtt/Att	-2.88	0	0	benign	0	neutral	0.45	neutral	2.74	neutral	-0.26	neutral	-0.23	neutral_impact	0.56	0.74	neutral	0.9	neutral	2.08	16.71	deleterious	0.35	0.55	0.32	neutral	0.41	neutral	0.18	neutral	0.44	neutral	1	0.55	neutral	0.73	deleterious	-6	neutral	0.17	neutral	2.07	high_impact	0.14	medium_impact	-0.58	medium_impact	0.88	0.9	10.14	12.66	0.56	N	0.24	polymorphism	1	0.02	rs879053914	.	.	.	.	.	.	.	7.27	G6150A	Prostate Cancer / enriched in POAG cohort	+	-	Reported	2	N	P	N,P	neutral
chrM	14626	14626	A	T	MI.24090	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	48	16	F	L	ttT/ttA	-2.11	0	0	probably_damaging	1	neutral	1	neutral	2.4	neutral	1.1	deleterious	-5.2	low_impact	1.37	0.88	neutral	0.89	neutral	2.66	20.60	deleterious	0.44	0.55	0.11	neutral	0.16	neutral	0.32	neutral	0.24	neutral	5	1	deleterious	0.5	deleterious	-2	neutral	0.65	deleterious	-3.55	low_impact	1.87	high_impact	0.01	medium_impact	0.75	0.85	17.26	11.64	0.36	N	0.75	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14627	14627	A	T	MI.24091	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	47	16	F	Y	tTt/tAt	-0.96	0	0	probably_damaging	1	neutral	0.73	neutral	2.09	neutral	-0.76	deleterious	-2.68	medium_impact	3.22	0.86	neutral	0.58	neutral	3.71	23.30	deleterious	0.35	0.5	0.41	neutral	0.48	neutral	0.55	disease	0.59	disease	2	1	deleterious	0.37	neutral	1	deleterious	0.72	deleterious	-3.55	low_impact	0.45	medium_impact	1.56	medium_impact	0.67	0.85	17.26	11.64	0.35	N	0.71	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14627	14627	A	G	MI.24092	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	47	16	F	S	tTt/tCt	-0.96	0	0	probably_damaging	1	neutral	0.57	neutral	2.09	neutral	2.7	deleterious	-7.03	medium_impact	2.6	0.86	neutral	0.77	neutral	4.20	23.90	deleterious	0.47	0.55	0.35	neutral	0.6	disease	0.56	disease	0.64	disease	3	1	deleterious	0.29	neutral	1	deleterious	0.73	deleterious	-3.55	low_impact	0.27	medium_impact	1.04	medium_impact	0.65	0.8	17.26	11.64	0.31	N	0.94	NA	NA	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14627	14627	A	C	MI.24093	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	47	16	F	C	tTt/tGt	-0.96	0	0	probably_damaging	1	neutral	0.17	neutral	2.07	neutral	-0.87	deleterious	-6.05	medium_impact	2.6	0.89	neutral	0.76	neutral	2.34	18.45	deleterious	0.29	0.45	0.25	neutral	0.7	disease	0.49	neutral	0.54	disease	1	1	deleterious	0.09	neutral	1	deleterious	0.69	deleterious	-3.55	low_impact	-0.18	medium_impact	1.04	medium_impact	0.46	0.8	17.26	11.64	0.44	N	0.49	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14628	14628	A	T	MI.24094	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	46	16	F	I	Ttt/Att	2.94	0.02	0	probably_damaging	1	neutral	0.59	neutral	2.26	neutral	0.4	deleterious	-5.21	medium_impact	2.67	0.85	neutral	0.67	neutral	3.78	23.40	deleterious	0.3	0.45	0.18	neutral	0.5	neutral	0.46	neutral	0.49	neutral	0	1	deleterious	0.3	neutral	1	deleterious	0.68	deleterious	-3.55	low_impact	0.29	medium_impact	1.1	medium_impact	0.68	0.85	17.26	11.64	0.29	N	0.81	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14628	14628	A	G	MI.24095	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	46	16	F	L	Ttt/Ctt	2.94	0.02	0	probably_damaging	1	neutral	1	neutral	2.4	neutral	1.1	deleterious	-5.2	low_impact	1.37	0.88	neutral	0.89	neutral	2.92	21.90	deleterious	0.44	0.55	0.11	neutral	0.16	neutral	0.32	neutral	0.24	neutral	5	1	deleterious	0.5	deleterious	-2	neutral	0.65	deleterious	-3.55	low_impact	1.87	high_impact	0.01	medium_impact	0.75	0.85	17.26	11.64	0.34	N	0.75	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14628	14628	A	C	MI.24096	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	46	16	F	V	Ttt/Gtt	2.94	0.02	0	probably_damaging	1	neutral	0.6	neutral	2.29	neutral	0.95	deleterious	-6.11	medium_impact	2.12	0.85	neutral	0.77	neutral	3.49	23.10	deleterious	0.34	0.5	0.14	neutral	0.59	disease	0.43	neutral	0.47	neutral	1	1	deleterious	0.3	neutral	1	deleterious	0.67	deleterious	-3.55	low_impact	0.3	medium_impact	0.64	medium_impact	0.72	0.85	17.26	11.64	0.28	N	0.89	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14630	14630	C	T	MI.24097	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	44	15	G	E	gGg/gAg	-7.38	0	0	probably_damaging	0.99	neutral	0.27	neutral	2.14	deleterious	-4.56	deleterious	-6.28	high_impact	3.84	0.57	damaging	0.17	damaging	3.95	23.60	deleterious	0.3	0.45	0.59	disease	0.84	disease	0.78	disease	0.81	disease	6	0.99	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-2.63	low_impact	-0.03	medium_impact	2.08	high_impact	0.83	0.9	11.5	26.27	0.39	N	0.92	NA	NA	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14630	14630	C	G	MI.24098	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	44	15	G	A	gGg/gCg	-7.38	0	0	probably_damaging	0.93	neutral	0.51	neutral	2.31	deleterious	-3.13	deleterious	-4.42	medium_impact	3.29	0.67	neutral	0.37	neutral	3.18	22.70	deleterious	0.46	0.55	0.33	neutral	0.69	disease	0.65	disease	0.62	disease	2	0.92	neutral	0.29	neutral	1	deleterious	0.74	deleterious	-1.83	low_impact	0.22	medium_impact	1.62	medium_impact	0.83	0.85	11.5	26.27	0.31	N	0.75	NA	NA	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14630	14630	C	A	MI.24099	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	44	15	G	V	gGg/gTg	-7.38	0	0	probably_damaging	0.99	neutral	0.51	neutral	2.24	deleterious	-3.55	deleterious	-7.36	high_impact	3.84	0.47	damaging	0.21	damaging	4.19	23.80	deleterious	0.25	0.45	0.3	neutral	0.87	disease	0.7	disease	0.79	disease	6	0.99	deleterious	0.26	neutral	2	deleterious	0.78	deleterious	-2.63	low_impact	0.22	medium_impact	2.08	high_impact	0.83	0.9	11.5	26.27	0.38	N	0.99	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8639	8639	T	A	MI.241	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	113	38	I	N	aTc/aAc	-3.8	0	0	probably_damaging	1	neutral	0.13	neutral	4.26	neutral	-2	deleterious	-4.58	medium_impact	2.73	0.87	neutral	0.59	neutral	4.28	24.00	deleterious	0.46	0.65	0.76	disease	0.73	disease	0.63	disease	0.71	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.18	medium_impact	1.24	medium_impact	0.51	0.9	15.49	18.25	0.36	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6150	6150	G	T	MI.2410	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	247	83	V	F	Gtt/Ttt	-2.88	0	0	possibly_damaging	0.69	deleterious	0	neutral	2.52	neutral	-2.37	deleterious	-2.84	high_impact	3.58	0.57	damaging	0.54	neutral	3.76	23.30	deleterious	0.14	0.55	0.66	disease	0.91	disease	0.43	neutral	0.74	disease	5	1	deleterious	0.16	neutral	5	deleterious	0.70	deleterious	-1.08	low_impact	-1.48	low_impact	2.21	high_impact	0.71	0.9	10.14	12.66	0.38	N	0.86	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14631	14631	C	A	MI.24100	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	43	15	G	W	Ggg/Tgg	1.1	0	0	probably_damaging	1	neutral	0.18	neutral	2.13	deleterious	-7.97	deleterious	-6.79	medium_impact	2.8	0.69	neutral	0.35	neutral	4.71	24.60	deleterious	0.2	0.45	0.92	disease	0.84	disease	0.64	disease	0.77	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.55	low_impact	-0.16	medium_impact	1.21	medium_impact	0.72	0.85	11.5	26.27	0.29	N	0.99	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14631	14631	C	G	MI.24101	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	43	15	G	R	Ggg/Cgg	1.1	0	0	probably_damaging	0.99	neutral	0.35	neutral	2.14	deleterious	-5.04	deleterious	-6.44	high_impact	3.84	0.51	damaging	0.14	damaging	4.01	23.60	deleterious	0.19	0.45	0.66	disease	0.87	disease	0.79	disease	0.83	disease	7	0.99	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-2.63	low_impact	0.06	medium_impact	2.08	high_impact	0.82	0.85	11.5	26.27	0.46	N	0.97	NA	NA	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14632	14632	C	G	MI.24102	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	42	14	M	I	atG/atC	0.41	0	0	benign	0.13	neutral	0.51	neutral	2.33	neutral	-1.79	neutral	0.57	neutral_impact	0.7	0.92	neutral	0.99	neutral	-0.57	0.15	neutral	0.53	0.6	0.13	neutral	0.29	neutral	0.38	neutral	0.42	neutral	2	0.4	neutral	0.69	deleterious	-6	neutral	0.16	neutral	-0.04	medium_impact	0.22	medium_impact	-0.55	medium_impact	0.69	0.85	13.72	12.42	0.39	N	0.74	NA	NA	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14632	14632	C	A	MI.24103	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	42	14	M	I	atG/atT	0.41	0	0	benign	0.13	neutral	0.51	neutral	2.33	neutral	-1.79	neutral	0.57	neutral_impact	0.7	0.92	neutral	0.99	neutral	-0.17	1.27	neutral	0.53	0.6	0.13	neutral	0.29	neutral	0.38	neutral	0.42	neutral	2	0.4	neutral	0.69	deleterious	-6	neutral	0.16	neutral	-0.04	medium_impact	0.22	medium_impact	-0.55	medium_impact	0.69	0.85	13.72	12.42	0.39	N	0.74	NA	NA	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14633	14633	A	G	MI.24104	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	41	14	M	T	aTg/aCg	-9.68	0	0	benign	0.02	neutral	0.25	neutral	2.31	deleterious	-3.75	neutral	-2.29	low_impact	1.5	0.85	neutral	0.84	neutral	-0.01	2.48	deleterious	0.44	0.55	0.16	neutral	0.33	neutral	0.64	disease	0.48	neutral	0	0.74	neutral	0.62	deleterious	-6	neutral	0.12	neutral	0.75	medium_impact	-0.06	medium_impact	0.12	medium_impact	0.56	0.8	13.72	12.42	0.4	N	0.49	NA	NA	0.03	.	.	.	.	.	.	COSM6716814	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14633	14633	A	T	MI.24105	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	41	14	M	K	aTg/aAg	-9.68	0	0	possibly_damaging	0.45	neutral	0.1	neutral	2.25	deleterious	-4.95	deleterious	-3.87	medium_impact	2.54	0.81	neutral	0.42	neutral	3.31	22.90	deleterious	0.29	0.45	0.34	neutral	0.66	disease	0.7	disease	0.76	disease	5	0.89	neutral	0.33	neutral	0	NA	0.50	deleterious	-0.72	medium_impact	-0.32	medium_impact	0.99	medium_impact	0.68	0.85	13.72	12.42	0.37	N	0.91	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14634	14634	T	A	MI.24106	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	40	14	M	L	Atg/Ttg	2.25	0.33	0.01	benign	0.06	neutral	1	neutral	2.39	neutral	-0.15	neutral	0.04	neutral_impact	0.3	0.9	neutral	0.99	neutral	-1.12	0.01	neutral	0.47	0.55	0.09	neutral	0.16	neutral	0.35	neutral	0.23	neutral	5	0.06	neutral	0.97	deleterious	-6	neutral	0.15	neutral	0.3	medium_impact	1.87	high_impact	-0.89	medium_impact	0.61	0.8	13.72	12.42	0.34	N	0.64	NA	NA	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14634	14634	T	C	MI.24107	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	40	14	M	V	Atg/Gtg	2.25	0.33	0.01	benign	0.01	neutral	0.68	neutral	2.34	neutral	-1.86	neutral	0.48	neutral_impact	-0.31	0.93	neutral	0.98	neutral	-2.20	0.00	neutral	0.6	0.65	0.09	neutral	0.21	neutral	0.37	neutral	0.33	neutral	3	0.31	neutral	0.84	deleterious	-6	neutral	0.08	neutral	1.03	medium_impact	0.39	medium_impact	-1.4	low_impact	0.62	0.8	13.72	12.42	0.4	N	0.40	NA	NA	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14634	14634	T	G	MI.24108	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	40	14	M	L	Atg/Ctg	2.25	0.33	0.01	benign	0.06	neutral	1	neutral	2.39	neutral	-0.15	neutral	0.04	neutral_impact	0.3	0.9	neutral	0.99	neutral	-1.20	0.01	neutral	0.47	0.55	0.09	neutral	0.16	neutral	0.35	neutral	0.23	neutral	5	0.06	neutral	0.97	deleterious	-6	neutral	0.15	neutral	0.3	medium_impact	1.87	high_impact	-0.89	medium_impact	0.61	0.8	13.72	12.42	0.34	N	0.64	NA	NA	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14636	14636	A	T	MI.24109	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	38	13	V	E	gTa/gAa	-20	0	0	probably_damaging	0.98	neutral	0.09	neutral	1.89	deleterious	-5.12	deleterious	-5.44	high_impact	3.77	0.83	neutral	0.36	neutral	4.03	23.60	deleterious	0.13	0.4	0.74	disease	0.88	disease	0.82	disease	0.85	disease	7	0.99	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-2.35	low_impact	-0.35	medium_impact	2.02	high_impact	0.57	0.8	15.49	16.77	0.37	N	0.92	NA	NA	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6150	6150	G	C	MI.2411	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	247	83	V	L	Gtt/Ctt	-2.88	0	0	benign	0.02	neutral	0.45	neutral	2.7	neutral	-0.57	neutral	-1.4	low_impact	1.08	0.56	damaging	0.55	neutral	2.23	17.73	deleterious	0.36	0.55	0.21	neutral	0.67	disease	0.2	neutral	0.45	neutral	1	0.53	neutral	0.72	deleterious	-6	neutral	0.19	neutral	0.83	medium_impact	0.14	medium_impact	-0.1	medium_impact	0.75	0.9	10.14	12.66	0.44	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14636	14636	A	G	MI.24110	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	38	13	V	A	gTa/gCa	-20	0	0	possibly_damaging	0.82	neutral	0.32	neutral	1.96	deleterious	-3.5	deleterious	-3.34	medium_impact	2.87	0.91	neutral	0.81	neutral	0.51	7.52	deleterious	0.35	0.5	0.43	neutral	0.62	disease	0.7	disease	0.55	disease	1	0.84	neutral	0.25	neutral	0	NA	0.68	deleterious	-1.4	low_impact	0.03	medium_impact	1.26	medium_impact	0.45	0.8	15.49	16.77	0.42	N	0.73	NA	NA	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14636	14636	A	C	MI.24111	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	38	13	V	G	gTa/gGa	-20	0	0	probably_damaging	0.98	neutral	0.26	neutral	1.9	deleterious	-5.18	deleterious	-6.29	high_impact	3.77	0.84	neutral	0.48	neutral	3.05	22.40	deleterious	0.18	0.45	0.75	disease	0.82	disease	0.74	disease	0.78	disease	6	0.98	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-2.35	low_impact	-0.05	medium_impact	2.02	high_impact	0.67	0.85	15.49	16.77	0.35	N	0.91	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14637	14637	C	G	MI.24112	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	37	13	V	L	Gta/Cta	4.54	0.32	0	possibly_damaging	0.62	neutral	0.62	neutral	2.07	neutral	-2.87	neutral	-2.34	medium_impact	2.05	0.9	neutral	0.81	neutral	0.85	9.76	deleterious	0.39	0.5	0.15	neutral	0.59	disease	0.52	disease	0.45	neutral	1	0.56	neutral	0.5	deleterious	0	NA	0.51	deleterious	-0.99	medium_impact	0.32	medium_impact	0.58	medium_impact	0.74	0.85	15.49	16.77	0.38	N	0.38	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14637	14637	C	T	MI.24113	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	37	13	V	M	Gta/Ata	4.54	0.32	0	probably_damaging	0.98	neutral	0.33	neutral	1.94	deleterious	-4.5	neutral	-2.38	medium_impact	2.48	0.89	neutral	0.66	neutral	3.65	23.20	deleterious	0.42	0.55	0.33	neutral	0.62	disease	0.56	disease	0.48	neutral	1	0.98	deleterious	0.18	neutral	1	deleterious	0.69	deleterious	-2.35	low_impact	0.04	medium_impact	0.94	medium_impact	0.71	0.85	15.49	16.77	0.41	N	0.65	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14637	14637	C	A	MI.24114	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	37	13	V	L	Gta/Tta	4.54	0.32	0	possibly_damaging	0.62	neutral	0.62	neutral	2.07	neutral	-2.87	neutral	-2.34	medium_impact	2.05	0.9	neutral	0.81	neutral	1.08	11.11	neutral	0.39	0.5	0.15	neutral	0.59	disease	0.52	disease	0.45	neutral	1	0.56	neutral	0.5	deleterious	0	NA	0.51	deleterious	-0.99	medium_impact	0.32	medium_impact	0.58	medium_impact	0.74	0.85	15.49	16.77	0.34	N	0.38	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14638	14638	T	A	MI.24115	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	36	12	L	F	ttA/ttT	0.18	0.07	0	possibly_damaging	0.45	neutral	0.69	neutral	2.08	neutral	-1.59	neutral	3.31	low_impact	1.18	0.83	neutral	0.97	neutral	1.04	10.88	neutral	0.39	0.5	0.15	neutral	0.22	neutral	0.33	neutral	0.38	neutral	2	0.36	neutral	0.62	deleterious	-3	neutral	0.41	neutral	-0.72	medium_impact	0.4	medium_impact	-0.15	medium_impact	0.68	0.85	50	8.94	0.29	N	0.18	NA	NA	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14638	14638	T	G	MI.24116	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	36	12	L	F	ttA/ttC	0.18	0.07	0	possibly_damaging	0.45	neutral	0.69	neutral	2.08	neutral	-1.59	neutral	3.31	low_impact	1.18	0.83	neutral	0.97	neutral	0.80	9.46	deleterious	0.39	0.5	0.15	neutral	0.22	neutral	0.33	neutral	0.38	neutral	2	0.36	neutral	0.62	deleterious	-3	neutral	0.41	neutral	-0.72	medium_impact	0.4	medium_impact	-0.15	medium_impact	0.68	0.85	50	8.94	0.3	N	0.18	NA	NA	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14639	14639	A	C	MI.24117	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	35	12	L	W	tTa/tGa	-1.65	0	0	probably_damaging	1	neutral	0.06	neutral	1.87	deleterious	-6.45	neutral	-0.75	medium_impact	3.02	0.75	neutral	0.3	neutral	3.21	22.70	deleterious	0.14	0.4	0.84	disease	0.86	disease	0.62	disease	0.76	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.84	deleterious	-3.55	low_impact	-0.46	medium_impact	1.39	medium_impact	0.59	0.8	50	8.94	0.32	N	0.72	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14639	14639	A	G	MI.24118	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	35	12	L	S	tTa/tCa	-1.65	0	0	probably_damaging	0.99	neutral	0.38	neutral	1.91	deleterious	-4.84	deleterious	-2.95	high_impact	3.57	0.74	neutral	0.22	damaging	3.66	23.20	deleterious	0.2	0.45	0.72	disease	0.84	disease	0.66	disease	0.77	disease	5	0.99	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-2.63	low_impact	0.09	medium_impact	1.85	medium_impact	0.63	0.8	50	8.94	0.31	N	0.82	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14640	14640	A	T	MI.24119	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	34	12	L	M	Tta/Ata	4.54	0.26	0	probably_damaging	0.99	neutral	0.4	neutral	1.95	neutral	-2.93	neutral	-0.49	medium_impact	2.07	0.77	neutral	0.45	neutral	3.05	22.40	deleterious	0.35	0.5	0.27	neutral	0.57	disease	0.42	neutral	0.48	neutral	0	0.99	deleterious	0.21	neutral	1	deleterious	0.69	deleterious	-2.63	low_impact	0.11	medium_impact	0.59	medium_impact	0.71	0.85	50	8.94	0.39	N	0.52	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6151	6151	T	G	MI.2412	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	248	83	V	G	gTt/gGt	1.05	0.8	0	possibly_damaging	0.84	deleterious	0	neutral	2.51	deleterious	-3.97	deleterious	-4.65	high_impact	4.56	0.65	neutral	0.63	neutral	3.80	23.40	deleterious	0.13	0.55	0.81	disease	0.81	disease	0.59	disease	0.72	disease	4	1	deleterious	0.08	neutral	5	deleterious	0.77	deleterious	-1.43	low_impact	-1.48	low_impact	3.11	high_impact	0.56	0.9	10.14	12.66	0.45	N	0.71	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14640	14640	A	C	MI.24120	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	34	12	L	V	Tta/Gta	4.54	0.26	0	probably_damaging	0.94	neutral	0.3	neutral	2.01	neutral	-2.46	neutral	-1.34	medium_impact	2.29	0.8	neutral	0.54	neutral	2.90	21.80	deleterious	0.35	0.5	0.37	neutral	0.7	disease	0.47	neutral	0.56	disease	1	0.95	neutral	0.18	neutral	1	deleterious	0.72	deleterious	-1.89	low_impact	0	medium_impact	0.78	medium_impact	0.68	0.85	50	8.94	0.38	N	0.51	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14642	14642	C	A	MI.24121	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	32	11	G	V	gGt/gTt	-5.78	0	0	benign	0	neutral	0.62	neutral	2.27	neutral	-1.12	neutral	5.22	low_impact	0.97	0.88	neutral	0.95	neutral	0.54	7.70	deleterious	0.32	0.5	0.09	neutral	0.81	disease	0.48	neutral	0.59	disease	2	0.37	neutral	0.81	deleterious	-6	neutral	0.13	neutral	1.95	medium_impact	0.32	medium_impact	-0.33	medium_impact	0.78	0.85	23.45	19.76	0.26	N	0.04	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14642	14642	C	G	MI.24122	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	32	11	G	A	gGt/gCt	-5.78	0	0	benign	0.02	neutral	0.52	neutral	2.24	neutral	-1.72	neutral	2.62	low_impact	0.98	0.86	neutral	0.93	neutral	-0.06	2.04	deleterious	0.5	0.6	0.13	neutral	0.62	disease	0.51	disease	0.44	neutral	1	0.45	neutral	0.75	deleterious	-6	neutral	0.13	neutral	0.75	medium_impact	0.23	medium_impact	-0.32	medium_impact	0.86	0.9	23.45	19.76	0.25	N	0.11	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14642	14642	C	T	MI.24123	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	32	11	G	D	gGt/gAt	-5.78	0	0	benign	0.16	neutral	0.18	neutral	2.13	deleterious	-4.01	neutral	0.15	medium_impact	2.52	0.78	neutral	0.41	neutral	2.06	16.62	deleterious	0.16	0.45	0.45	neutral	0.89	disease	0.69	disease	0.79	disease	6	0.79	neutral	0.51	deleterious	-3	neutral	0.36	neutral	-0.14	medium_impact	-0.16	medium_impact	0.97	medium_impact	0.68	0.85	23.45	19.76	0.34	N	0.32	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14643	14643	C	T	MI.24124	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	31	11	G	S	Ggt/Agt	1.1	0	0	benign	0.06	neutral	0.54	neutral	2.2	neutral	-2.36	neutral	1.64	low_impact	1.71	0.83	neutral	0.89	neutral	2.32	18.32	deleterious	0.37	0.5	0.21	neutral	0.65	disease	0.43	neutral	0.47	neutral	1	0.4	neutral	0.74	deleterious	-6	neutral	0.15	neutral	0.3	medium_impact	0.25	medium_impact	0.29	medium_impact	0.90	0.95	23.45	19.76	0.34	N	0.03	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14643	14643	C	G	MI.24125	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	31	11	G	R	Ggt/Cgt	1.1	0	0	benign	0.16	neutral	0.31	neutral	2.15	deleterious	-3.18	neutral	0.97	medium_impact	2.52	0.79	neutral	0.42	neutral	2.18	17.40	deleterious	0.2	0.45	0.33	neutral	0.9	disease	0.72	disease	0.8	disease	6	0.64	neutral	0.58	deleterious	-3	neutral	0.38	neutral	-0.14	medium_impact	0.01	medium_impact	0.97	medium_impact	0.81	0.85	23.45	19.76	0.34	N	0.23	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14643	14643	C	A	MI.24126	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	31	11	G	C	Ggt/Tgt	1.1	0	0	possibly_damaging	0.59	neutral	0.26	neutral	2.2	deleterious	-3.87	neutral	2.26	neutral_impact	0.67	0.79	neutral	0.78	neutral	4.19	23.80	deleterious	0.25	0.45	0.23	neutral	0.68	disease	0.47	neutral	0.49	neutral	0	0.75	neutral	0.34	neutral	-3	neutral	0.51	deleterious	-0.94	medium_impact	-0.05	medium_impact	-0.58	medium_impact	0.80	0.85	23.45	19.76	0.34	N	0.26	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14645	14645	A	T	MI.24127	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	29	10	V	E	gTg/gAg	-7.38	0	0	probably_damaging	0.97	neutral	0.13	neutral	2.1	deleterious	-4.14	deleterious	-4.81	medium_impact	3.37	0.86	neutral	0.51	neutral	4.14	23.80	deleterious	0.22	0.45	0.47	neutral	0.84	disease	0.76	disease	0.8	disease	6	0.99	deleterious	0.08	neutral	1	deleterious	0.76	deleterious	-2.18	low_impact	-0.25	medium_impact	1.68	medium_impact	0.75	0.85	27.43	16.7	0.42	N	0.90	NA	NA	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14645	14645	A	G	MI.24128	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	29	10	V	A	gTg/gCg	-7.38	0	0	possibly_damaging	0.77	neutral	0.27	neutral	2.17	neutral	-2.56	deleterious	-3.1	medium_impact	2.56	0.84	neutral	0.75	neutral	1.56	13.63	neutral	0.43	0.55	0.18	neutral	0.57	disease	0.56	disease	0.62	disease	2	0.83	neutral	0.25	neutral	0	NA	0.58	deleterious	-1.28	low_impact	-0.03	medium_impact	1	medium_impact	0.68	0.85	27.43	16.7	0.35	N	0.47	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14645	14645	A	C	MI.24129	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	29	10	V	G	gTg/gGg	-7.38	0	0	probably_damaging	0.97	neutral	0.32	neutral	2.11	neutral	-1.82	deleterious	-5.76	medium_impact	2.33	0.86	neutral	0.7	neutral	1.94	15.81	deleterious	0.31	0.45	0.47	neutral	0.73	disease	0.59	disease	0.7	disease	4	0.97	neutral	0.18	neutral	1	deleterious	0.71	deleterious	-2.18	low_impact	0.03	medium_impact	0.81	medium_impact	0.72	0.85	27.43	16.7	0.31	N	0.85	NA	NA	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6151	6151	T	C	MI.2413	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	248	83	V	A	gTt/gCt	1.05	0.8	0	benign	0.42	deleterious	0	neutral	2.59	neutral	-1.93	deleterious	-2.6	high_impact	3.52	0.66	neutral	0.67	neutral	3.51	23.10	deleterious	0.33	0.55	0.58	disease	0.77	disease	0.54	disease	0.69	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.42	neutral	-0.62	medium_impact	-1.48	low_impact	2.15	high_impact	0.55	0.9	10.14	12.66	0.37	N	0.47	polymorphism	0.78	0.14	rs1041870	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14646	14646	C	A	MI.24130	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	28	10	V	L	Gtg/Ttg	0.64	0	0	benign	0.39	neutral	1	neutral	2.34	neutral	-1.46	neutral	-1.74	low_impact	1.48	0.89	neutral	0.91	neutral	0.73	9.04	deleterious	0.47	0.55	0.12	neutral	0.5	disease	0.32	neutral	0.43	neutral	1	0.39	neutral	0.81	deleterious	-6	neutral	0.41	neutral	-0.62	medium_impact	1.87	high_impact	0.1	medium_impact	0.88	0.9	27.43	16.7	0.28	N	0.36	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14646	14646	C	T	MI.24131	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	28	10	V	M	Gtg/Atg	0.64	0	0	possibly_damaging	0.54	neutral	0.36	neutral	2.16	neutral	-2.4	neutral	-1.92	medium_impact	2.01	0.88	neutral	0.87	neutral	0.82	9.59	deleterious	0.51	0.6	0.23	neutral	0.43	neutral	0.36	neutral	0.45	neutral	1	0.64	neutral	0.41	neutral	0	NA	0.50	deleterious	-0.86	medium_impact	0.07	medium_impact	0.54	medium_impact	0.84	0.9	27.43	16.7	0.42	N	0.60	NA	NA	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14646	14646	C	G	MI.24132	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	28	10	V	L	Gtg/Ctg	0.64	0	0	benign	0.39	neutral	1	neutral	2.34	neutral	-1.46	neutral	-1.74	low_impact	1.48	0.89	neutral	0.91	neutral	0.40	6.61	deleterious	0.47	0.55	0.12	neutral	0.5	disease	0.32	neutral	0.43	neutral	1	0.39	neutral	0.81	deleterious	-6	neutral	0.41	neutral	-0.62	medium_impact	1.87	high_impact	0.1	medium_impact	0.88	0.9	27.43	16.7	0.28	N	0.36	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14648	14648	C	G	MI.24133	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	26	9	S	T	aGt/aCt	-2.34	0	0	probably_damaging	1	neutral	0.25	neutral	2.27	neutral	-2.19	deleterious	-2.99	medium_impact	2.75	0.84	neutral	0.22	damaging	3.45	23.00	deleterious	0.29	0.45	0.29	neutral	0.47	neutral	0.55	disease	0.53	disease	1	1	deleterious	0.13	neutral	1	deleterious	0.72	deleterious	-3.55	low_impact	-0.06	medium_impact	1.16	medium_impact	0.75	0.85	49.56	8.77	0.32	N	0.68	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14648	14648	C	T	MI.24134	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	26	9	S	N	aGt/aAt	-2.34	0	0	probably_damaging	1	neutral	0.11	neutral	2.21	deleterious	-3.01	deleterious	-2.99	high_impact	3.56	0.76	neutral	0.15	damaging	3.57	23.10	deleterious	0.49	0.55	0.39	neutral	0.63	disease	0.58	disease	0.72	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.75	deleterious	-3.55	low_impact	-0.3	medium_impact	1.84	medium_impact	0.67	0.85	49.56	8.77	0.37	N	0.82	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14648	14648	C	A	MI.24135	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	26	9	S	I	aGt/aTt	-2.34	0	0	probably_damaging	1	neutral	0.41	neutral	2.29	neutral	-2.21	deleterious	-5.87	medium_impact	2.66	0.83	neutral	0.17	damaging	4.23	23.90	deleterious	0.37	0.5	0.3	neutral	0.85	disease	0.47	neutral	0.78	disease	6	1	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-3.55	low_impact	0.12	medium_impact	1.09	medium_impact	0.89	0.9	49.56	8.77	0.25	N	0.98	NA	NA	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14649	14649	T	C	MI.24136	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	25	9	S	G	Agt/Ggt	2.48	0.02	0	probably_damaging	1	neutral	0.28	neutral	2.28	neutral	-1.1	deleterious	-3.96	medium_impact	2.12	0.79	neutral	0.38	neutral	3.24	22.80	deleterious	0.34	0.5	0.28	neutral	0.34	neutral	0.46	neutral	0.45	neutral	1	1	deleterious	0.14	neutral	1	deleterious	0.69	deleterious	-3.55	low_impact	-0.02	medium_impact	0.64	medium_impact	0.77	0.85	49.56	8.77	0.4	N	0.83	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14649	14649	T	A	MI.24137	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	25	9	S	C	Agt/Tgt	2.48	0.02	0	probably_damaging	1	neutral	0.12	neutral	2.21	deleterious	-4.32	deleterious	-4.92	medium_impact	3.01	0.78	neutral	0.27	damaging	3.61	23.20	deleterious	0.37	0.5	0.6	disease	0.77	disease	0.54	disease	0.75	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.77	deleterious	-3.55	low_impact	-0.27	medium_impact	1.38	medium_impact	0.79	0.85	49.56	8.77	0.35	N	0.98	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14649	14649	T	G	MI.24138	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	25	9	S	R	Agt/Cgt	2.48	0.02	0	probably_damaging	1	neutral	0.1	neutral	2.22	neutral	-2.91	deleterious	-4.91	high_impact	3.56	0.82	neutral	0.14	damaging	3.87	23.50	deleterious	0.23	0.45	0.37	neutral	0.87	disease	0.69	disease	0.8	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.81	deleterious	-3.55	low_impact	-0.32	medium_impact	1.84	medium_impact	0.91	0.95	49.56	8.77	0.36	N	1.00	NA	NA	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14650	14650	C	G	MI.24139	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	24	8	L	F	ttG/ttC	0.41	0.01	0	benign	0.32	neutral	0.74	neutral	2.07	neutral	-2.55	deleterious	-3.42	low_impact	1.7	0.9	neutral	0.94	neutral	0.54	7.71	deleterious	0.4	0.5	0.57	disease	0.22	neutral	0.35	neutral	0.53	disease	1	0.22	neutral	0.71	deleterious	-6	neutral	0.37	neutral	-0.5	medium_impact	0.46	medium_impact	0.28	medium_impact	0.70	0.85	21.24	17.86	0.41	N	0.85	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6151	6151	T	A	MI.2414	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	248	83	V	D	gTt/gAt	1.05	0.8	0	possibly_damaging	0.85	deleterious	0	neutral	2.48	deleterious	-5.08	deleterious	-4.46	high_impact	4.56	0.57	damaging	0.49	neutral	4.50	24.30	deleterious	0.09	0.55	0.89	disease	0.91	disease	0.68	disease	0.81	disease	6	1	deleterious	0.08	neutral	5	deleterious	0.78	deleterious	-1.47	low_impact	-1.48	low_impact	3.11	high_impact	0.58	0.9	10.14	12.66	0.45	N	0.83	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14650	14650	C	A	MI.24140	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	24	8	L	F	ttG/ttT	0.41	0.01	0	benign	0.32	neutral	0.74	neutral	2.07	neutral	-2.55	deleterious	-3.42	low_impact	1.7	0.9	neutral	0.94	neutral	0.92	10.20	neutral	0.4	0.5	0.57	disease	0.22	neutral	0.35	neutral	0.53	disease	1	0.22	neutral	0.71	deleterious	-6	neutral	0.37	neutral	-0.5	medium_impact	0.46	medium_impact	0.28	medium_impact	0.70	0.85	21.24	17.86	0.38	N	0.85	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14651	14651	A	G	MI.24141	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	23	8	L	S	tTg/tCg	-4.4	0	0	probably_damaging	0.98	neutral	0.48	neutral	1.99	deleterious	-4.37	deleterious	-5.25	medium_impact	2.54	0.81	neutral	0.82	neutral	3.59	23.20	deleterious	0.26	0.45	0.32	neutral	0.69	disease	0.6	disease	0.56	disease	1	0.98	deleterious	0.25	neutral	1	deleterious	0.74	deleterious	-2.35	low_impact	0.19	medium_impact	0.99	medium_impact	0.75	0.85	21.24	17.86	0.27	N	0.90	NA	NA	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14651	14651	A	C	MI.24142	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	23	8	L	W	tTg/tGg	-4.4	0	0	probably_damaging	0.99	neutral	0.1	neutral	1.93	deleterious	-6.42	deleterious	-5.28	medium_impact	2.99	0.76	neutral	0.64	neutral	3.21	22.70	deleterious	0.14	0.4	0.86	disease	0.78	disease	0.62	disease	0.76	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.82	deleterious	-2.63	low_impact	-0.32	medium_impact	1.37	medium_impact	0.61	0.8	21.24	17.86	0.33	N	0.91	NA	NA	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14652	14652	A	C	MI.24143	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	22	8	L	V	Ttg/Gtg	5.46	0.55	0	possibly_damaging	0.87	neutral	0.31	neutral	2.07	neutral	-2.1	deleterious	-2.64	medium_impact	2.64	0.81	neutral	0.79	neutral	2.64	20.40	deleterious	0.35	0.5	0.4	neutral	0.6	disease	0.44	neutral	0.49	neutral	0	0.89	neutral	0.22	neutral	0	NA	0.70	deleterious	-1.55	low_impact	0.01	medium_impact	1.07	medium_impact	0.68	0.85	21.24	17.86	0.44	N	0.69	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14652	14652	A	T	MI.24144	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	22	8	L	M	Ttg/Atg	5.46	0.55	0	probably_damaging	0.98	neutral	0.35	neutral	1.99	deleterious	-3.45	neutral	-1.21	medium_impact	2.17	0.84	neutral	0.97	neutral	1.95	15.88	deleterious	0.34	0.5	0.58	disease	0.4	neutral	0.37	neutral	0.61	disease	2	0.99	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-2.35	low_impact	0.06	medium_impact	0.68	medium_impact	0.67	0.85	21.24	17.86	0.51	N	0.64	NA	NA	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14654	14654	A	C	MI.24145	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	20	7	L	R	cTg/cGg	-5.32	0	0	possibly_damaging	0.79	deleterious	0.03	neutral	1.92	deleterious	-4.39	deleterious	-4.74	medium_impact	3.45	0.73	neutral	0.44	neutral	3.37	22.90	deleterious	0.17	0.45	0.67	disease	0.88	disease	0.76	disease	0.84	disease	7	0.98	neutral	0.12	neutral	4	deleterious	0.77	deleterious	-1.32	low_impact	-0.63	medium_impact	1.75	medium_impact	0.74	0.85	9.29	10.06	0.35	N	0.64	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14654	14654	A	T	MI.24146	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	20	7	L	Q	cTg/cAg	-5.32	0	0	possibly_damaging	0.88	deleterious	0.03	neutral	1.91	deleterious	-4.43	deleterious	-4.55	medium_impact	3.45	0.79	neutral	0.51	neutral	3.38	23.00	deleterious	0.21	0.45	0.67	disease	0.69	disease	0.65	disease	0.73	disease	5	0.99	deleterious	0.08	neutral	4	deleterious	0.71	deleterious	-1.59	low_impact	-0.63	medium_impact	1.75	medium_impact	0.80	0.85	9.29	10.06	0.38	N	0.68	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14654	14654	A	G	MI.24147	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	20	7	L	P	cTg/cCg	-5.32	0	0	possibly_damaging	0.79	neutral	0.05	neutral	1.91	deleterious	-4.95	deleterious	-5.08	medium_impact	3.1	0.74	neutral	0.4	neutral	3.52	23.10	deleterious	0.16	0.45	0.72	disease	0.86	disease	0.65	disease	0.77	disease	5	0.97	neutral	0.13	neutral	0	NA	0.76	deleterious	-1.32	low_impact	-0.5	medium_impact	1.46	medium_impact	0.72	0.85	9.29	10.06	0.35	N	0.82	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14655	14655	G	C	MI.24148	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	19	7	L	V	Ctg/Gtg	1.1	0	0	benign	0.02	neutral	0.32	neutral	2.05	neutral	-0.8	neutral	-0.28	low_impact	1.4	0.9	neutral	0.95	neutral	-0.28	0.72	neutral	0.42	0.5	0.14	neutral	0.4	neutral	0.4	neutral	0.45	neutral	1	0.67	neutral	0.65	deleterious	-6	neutral	0.10	neutral	0.75	medium_impact	0.03	medium_impact	0.03	medium_impact	0.76	0.85	9.29	10.06	0.47	N	0.20	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14655	14655	G	T	MI.24149	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	19	7	L	M	Ctg/Atg	1.1	0	0	possibly_damaging	0.84	neutral	0.3	neutral	1.97	neutral	-2.16	neutral	-0.76	low_impact	1.93	0.88	neutral	0.92	neutral	0.19	4.53	deleterious	0.36	0.5	0.36	neutral	0.31	neutral	0.33	neutral	0.46	neutral	1	0.87	neutral	0.23	neutral	-3	neutral	0.59	deleterious	-1.46	low_impact	0	medium_impact	0.48	medium_impact	0.62	0.8	9.29	10.06	0.49	N	0.32	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6153	6153	C	T	MI.2415	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	250	84	P	S	Ccc/Tcc	-20	0	0	possibly_damaging	0.8	deleterious	0	neutral	1.73	deleterious	-3.16	deleterious	-5.48	high_impact	4.89	0.68	neutral	0.04	damaging	3.82	23.40	deleterious	0.27	0.55	0.68	disease	0.87	disease	0.64	disease	0.73	disease	5	1	deleterious	0.1	neutral	5	deleterious	0.73	deleterious	-1.32	low_impact	-1.48	low_impact	3.42	high_impact	0.37	0.9	2.92	6.76	0.56	N	0.85	polymorphism	0.94	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14656	14656	A	T	MI.24150	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	18	6	F	L	ttT/ttA	-2.11	0	0	benign	0.04	neutral	0.79	neutral	2.29	neutral	-1.93	deleterious	-4.9	low_impact	1.5	0.93	neutral	0.77	neutral	0.70	8.80	deleterious	0.26	0.45	0.18	neutral	0.54	disease	0.47	neutral	0.46	neutral	1	0.14	neutral	0.88	deleterious	-6	neutral	0.15	neutral	0.47	medium_impact	0.53	medium_impact	0.12	medium_impact	0.50	0.8	39.82	8.43	0.32	N	0.84	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14656	14656	A	C	MI.24151	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	18	6	F	L	ttT/ttG	-2.11	0	0	benign	0.04	neutral	0.79	neutral	2.29	neutral	-1.93	deleterious	-4.9	low_impact	1.5	0.93	neutral	0.77	neutral	0.62	8.29	deleterious	0.26	0.45	0.18	neutral	0.54	disease	0.47	neutral	0.46	neutral	1	0.14	neutral	0.88	deleterious	-6	neutral	0.15	neutral	0.47	medium_impact	0.53	medium_impact	0.12	medium_impact	0.50	0.8	39.82	8.43	0.32	N	0.84	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14657	14657	A	G	MI.24152	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	17	6	F	S	tTt/tCt	-0.04	0	0	probably_damaging	0.91	neutral	0.45	neutral	2.2	neutral	-0.93	deleterious	-6.25	medium_impact	2.25	0.85	neutral	0.77	neutral	4.28	24.00	deleterious	0.4	0.5	0.17	neutral	0.65	disease	0.54	disease	0.47	neutral	1	0.9	neutral	0.27	neutral	1	deleterious	0.68	deleterious	-1.72	low_impact	0.16	medium_impact	0.75	medium_impact	0.69	0.85	39.82	8.43	0.28	N	0.93	NA	NA	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14657	14657	A	C	MI.24153	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	17	6	F	C	tTt/tGt	-0.04	0	0	probably_damaging	0.97	neutral	0.13	neutral	2.13	deleterious	-4.48	deleterious	-6.73	medium_impact	2.46	0.83	neutral	0.69	neutral	3.77	23.40	deleterious	0.28	0.45	0.56	disease	0.78	disease	0.5	neutral	0.6	disease	2	0.98	deleterious	0.08	neutral	1	deleterious	0.73	deleterious	-2.18	low_impact	-0.25	medium_impact	0.92	medium_impact	0.45	0.8	39.82	8.43	0.37	N	0.96	NA	NA	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14657	14657	A	T	MI.24154	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	17	6	F	Y	tTt/tAt	-0.04	0	0	possibly_damaging	0.78	neutral	0.39	neutral	2.17	deleterious	-3.24	neutral	-1.76	low_impact	1.69	0.85	neutral	0.92	neutral	2.23	17.73	deleterious	0.25	0.45	0.41	neutral	0.58	disease	0.47	neutral	0.49	neutral	0	0.79	neutral	0.31	neutral	-3	neutral	0.65	deleterious	-1.3	low_impact	0.1	medium_impact	0.28	medium_impact	0.58	0.8	39.82	8.43	0.37	N	0.49	NA	NA	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14658	14658	A	C	MI.24155	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	16	6	F	V	Ttt/Gtt	-0.04	0	0	possibly_damaging	0.57	neutral	0.43	neutral	2.25	neutral	-2.04	deleterious	-5.73	medium_impact	2.37	0.81	neutral	0.73	neutral	2.11	16.90	deleterious	0.29	0.45	0.15	neutral	0.78	disease	0.52	disease	0.58	disease	2	0.6	neutral	0.43	neutral	0	NA	0.53	deleterious	-0.91	medium_impact	0.14	medium_impact	0.85	medium_impact	0.61	0.8	39.82	8.43	0.31	N	0.90	NA	NA	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14658	14658	A	G	MI.24156	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	16	6	F	L	Ttt/Ctt	-0.04	0	0	benign	0.04	neutral	0.79	neutral	2.29	neutral	-1.93	deleterious	-4.9	low_impact	1.5	0.93	neutral	0.77	neutral	0.94	10.33	neutral	0.26	0.45	0.18	neutral	0.54	disease	0.47	neutral	0.46	neutral	1	0.14	neutral	0.88	deleterious	-6	neutral	0.15	neutral	0.47	medium_impact	0.53	medium_impact	0.12	medium_impact	0.50	0.8	39.82	8.43	0.3	N	0.84	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14658	14658	A	T	MI.24157	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	16	6	F	I	Ttt/Att	-0.04	0	0	possibly_damaging	0.44	neutral	0.46	neutral	2.21	neutral	-2.46	deleterious	-4.97	medium_impact	2.37	0.82	neutral	0.7	neutral	2.24	17.78	deleterious	0.2	0.45	0.17	neutral	0.74	disease	0.5	neutral	0.58	disease	1	0.5	neutral	0.51	deleterious	0	NA	0.50	deleterious	-0.7	medium_impact	0.17	medium_impact	0.85	medium_impact	0.59	0.8	39.82	8.43	0.3	N	0.88	NA	NA	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14659	14659	C	A	MI.24158	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	15	5	L	F	ttG/ttT	1.1	0	0	probably_damaging	0.99	neutral	0.84	neutral	2.17	deleterious	-4.88	neutral	-1.87	low_impact	1.84	0.83	neutral	0.41	neutral	4.04	23.70	deleterious	0.42	0.55	0.44	neutral	0.27	neutral	0.4	neutral	0.45	neutral	1	0.99	deleterious	0.43	neutral	-2	neutral	0.66	deleterious	-2.63	low_impact	0.61	medium_impact	0.4	medium_impact	0.78	0.85	50.44	8.42	0.25	N	0.31	NA	NA	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14659	14659	C	G	MI.24159	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	15	5	L	F	ttG/ttC	1.1	0	0	probably_damaging	0.99	neutral	0.84	neutral	2.17	deleterious	-4.88	neutral	-1.87	low_impact	1.84	0.83	neutral	0.41	neutral	3.58	23.20	deleterious	0.42	0.55	0.44	neutral	0.27	neutral	0.4	neutral	0.45	neutral	1	0.99	deleterious	0.43	neutral	-2	neutral	0.66	deleterious	-2.63	low_impact	0.61	medium_impact	0.4	medium_impact	0.78	0.85	50.44	8.42	0.23	N	0.31	NA	NA	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6153	6153	C	A	MI.2416	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	250	84	P	T	Ccc/Acc	-20	0	0	possibly_damaging	0.63	deleterious	0	neutral	1.55	deleterious	-5.74	deleterious	-5.49	high_impact	5.24	0.69	neutral	0.04	damaging	3.58	23.20	deleterious	0.23	0.55	0.72	disease	0.88	disease	0.63	disease	0.73	disease	5	1	deleterious	0.19	neutral	5	deleterious	0.62	deleterious	-0.97	medium_impact	-1.48	low_impact	3.74	high_impact	0.67	0.9	2.92	6.76	0.5	N	0.80	polymorphism	0.94	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14660	14660	A	C	MI.24160	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	14	5	L	W	tTg/tGg	-8.76	0	0	probably_damaging	1	neutral	0.09	neutral	2.11	deleterious	-8.03	deleterious	-3.49	medium_impact	2.58	0.79	neutral	0.21	damaging	3.09	22.50	deleterious	0.18	0.45	0.81	disease	0.47	neutral	0.63	disease	0.69	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.75	deleterious	-3.55	low_impact	-0.35	medium_impact	1.02	medium_impact	0.59	0.8	50.44	8.42	0.28	N	0.74	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14660	14660	A	G	MI.24161	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	14	5	L	S	tTg/tCg	-8.76	0	0	probably_damaging	0.92	neutral	0.22	neutral	2.18	deleterious	-6.33	deleterious	-2.78	low_impact	1.51	0.85	neutral	0.47	neutral	3.41	23.00	deleterious	0.29	0.45	0.53	disease	0.23	neutral	0.41	neutral	0.36	neutral	3	0.94	neutral	0.15	neutral	-2	neutral	0.67	deleterious	-1.77	low_impact	-0.1	medium_impact	0.13	medium_impact	0.82	0.85	50.44	8.42	0.39	N	0.62	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14661	14661	A	T	MI.24162	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	13	5	L	M	Ttg/Atg	1.56	0	0	probably_damaging	0.99	neutral	0.56	neutral	2.26	deleterious	-4.52	neutral	0.23	low_impact	1.19	0.88	neutral	0.89	neutral	1.80	14.97	neutral	0.36	0.5	0.28	neutral	0.05	neutral	0.26	neutral	0.21	neutral	6	0.99	deleterious	0.29	neutral	-2	neutral	0.61	deleterious	-2.63	low_impact	0.27	medium_impact	-0.14	medium_impact	0.77	0.85	50.44	8.42	0.39	N	0.15	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14661	14661	A	C	MI.24163	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	13	5	L	V	Ttg/Gtg	1.56	0	0	possibly_damaging	0.87	neutral	0.53	neutral	2.37	neutral	-2.22	neutral	1.27	neutral_impact	0.6	0.91	neutral	0.94	neutral	-1.59	0.00	neutral	0.45	0.55	0.11	neutral	0.06	neutral	0.29	neutral	0.17	neutral	7	0.85	neutral	0.33	neutral	-3	neutral	0.56	deleterious	-1.55	low_impact	0.24	medium_impact	-0.64	medium_impact	0.85	0.9	50.44	8.42	0.39	N	0.18	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14663	14663	G	C	MI.24164	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	11	4	A	G	gCt/gGt	-2.11	0	0	benign	0.21	neutral	0.2	neutral	2.24	deleterious	-3.84	deleterious	-2.7	low_impact	1.45	0.81	neutral	0.6	neutral	1.72	14.53	neutral	0.36	0.5	0.42	neutral	0.14	neutral	0.33	neutral	0.33	neutral	3	0.76	neutral	0.5	deleterious	-6	neutral	0.24	neutral	-0.27	medium_impact	-0.13	medium_impact	0.08	medium_impact	0.90	0.95	41.59	7.51	0.43	N	0.47	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14663	14663	G	T	MI.24165	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	11	4	A	D	gCt/gAt	-2.11	0	0	benign	0.4	neutral	0.05	neutral	2.22	deleterious	-4.41	neutral	-2.47	low_impact	1.8	0.85	neutral	0.55	neutral	2.26	17.88	deleterious	0.32	0.5	0.53	disease	0.41	neutral	0.61	disease	0.48	neutral	0	0.94	neutral	0.33	neutral	-6	neutral	0.46	deleterious	-0.64	medium_impact	-0.5	medium_impact	0.37	medium_impact	0.84	0.9	41.59	7.51	0.39	N	0.71	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14663	14663	G	A	MI.24166	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	11	4	A	V	gCt/gTt	-2.11	0	0	benign	0.01	neutral	0.37	neutral	2.4	neutral	-1.66	neutral	2.42	neutral_impact	-0.47	0.97	neutral	0.97	neutral	-0.19	1.13	neutral	0.41	0.5	0.16	neutral	0.08	neutral	0.22	neutral	0.27	neutral	5	0.62	neutral	0.68	deleterious	-6	neutral	0.06	neutral	1.03	medium_impact	0.08	medium_impact	-1.53	low_impact	0.96	1	41.59	7.51	0.42	N	0.12	NA	NA	0.00	.	not_provided	Mitochondrial_DNA-related_disorder	434698	MedGen:CN552492	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14664	14664	C	A	MI.24167	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	10	4	A	S	Gct/Tct	0.41	0	0	benign	0.14	neutral	0.24	neutral	2.28	neutral	-2.83	neutral	-1.14	low_impact	1.25	0.85	neutral	0.85	neutral	1.21	11.80	neutral	0.45	0.55	0.28	neutral	0.11	neutral	0.34	neutral	0.33	neutral	3	0.72	neutral	0.55	deleterious	-6	neutral	0.16	neutral	-0.07	medium_impact	-0.07	medium_impact	-0.09	medium_impact	0.96	1	41.59	7.51	0.51	N	0.51	NA	NA	0.03	rs386829223	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14664	14664	C	G	MI.24168	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	10	4	A	P	Gct/Cct	0.41	0	0	possibly_damaging	0.48	neutral	0.13	neutral	2.23	deleterious	-4.42	neutral	-2.07	low_impact	1.8	0.84	neutral	0.5	neutral	2.32	18.32	deleterious	0.2	0.45	0.49	neutral	0.46	neutral	0.36	neutral	0.43	neutral	1	0.85	neutral	0.33	neutral	-3	neutral	0.54	deleterious	-0.76	medium_impact	-0.25	medium_impact	0.37	medium_impact	0.94	0.95	41.59	7.51	0.43	N	0.71	NA	NA	0.04	rs386829223	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14664	14664	C	T	MI.24169	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	10	4	A	T	Gct/Act	0.41	0	0	benign	0.01	neutral	0.2	neutral	2.3	neutral	-2.63	neutral	0.04	neutral_impact	-0.08	0.94	neutral	0.91	neutral	1.05	10.94	neutral	0.57	0.65	0.24	neutral	0.07	neutral	0.21	neutral	0.26	neutral	5	0.8	neutral	0.6	deleterious	-6	neutral	0.08	neutral	1.03	medium_impact	-0.13	medium_impact	-1.21	low_impact	0.92	0.95	41.59	7.51	0.62	P	0.37	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6153	6153	C	G	MI.2417	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	250	84	P	A	Ccc/Gcc	-20	0	0	benign	0.16	deleterious	0	neutral	1.63	deleterious	-4.08	deleterious	-5.49	high_impact	5.24	0.68	neutral	0.06	damaging	2.99	22.20	deleterious	0.2	0.55	0.48	neutral	0.81	disease	0.64	disease	0.7	disease	4	1	deleterious	0.42	neutral	2	deleterious	0.36	neutral	-0.08	medium_impact	-1.48	low_impact	3.74	high_impact	0.66	0.9	2.92	6.76	0.47	N	0.76	polymorphism	0.96	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14666	14666	T	G	MI.24170	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	8	3	Y	S	tAt/tCt	-1.65	0	0	probably_damaging	1	neutral	0.26	neutral	1.75	deleterious	-3.61	deleterious	-6.56	medium_impact	3.27	0.85	neutral	0.2	damaging	3.80	23.40	deleterious	0.33	0.5	0.68	disease	0.62	disease	0.62	disease	0.66	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	-0.05	medium_impact	1.6	medium_impact	0.33	0.8	15.93	14.48	0.3	N	0.73	NA	NA	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14666	14666	T	A	MI.24171	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	8	3	Y	F	tAt/tTt	-1.65	0	0	probably_damaging	1	neutral	0.54	neutral	1.84	deleterious	-3.44	deleterious	-3.4	medium_impact	2.37	0.87	neutral	0.54	neutral	3.43	23.00	deleterious	0.34	0.5	0.24	neutral	0.38	neutral	0.42	neutral	0.4	neutral	2	1	deleterious	0.27	neutral	1	deleterious	0.69	deleterious	-3.55	low_impact	0.25	medium_impact	0.85	medium_impact	0.61	0.8	15.93	14.48	0.3	N	0.53	NA	NA	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14666	14666	T	C	MI.24172	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	8	3	Y	C	tAt/tGt	-1.65	0	0	probably_damaging	1	neutral	0.09	neutral	1.72	deleterious	-5.96	deleterious	-7.39	medium_impact	3.27	0.78	neutral	0.09	damaging	3.18	22.70	deleterious	0.36	0.5	0.86	disease	0.66	disease	0.67	disease	0.74	disease	5	1	deleterious	0.05	neutral	1	deleterious	0.79	deleterious	-3.55	low_impact	-0.35	medium_impact	1.6	medium_impact	0.27	0.8	15.93	14.48	0.28	N	0.75	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14667	14667	A	T	MI.24173	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	7	3	Y	N	Tat/Aat	0.18	0	0	probably_damaging	1	neutral	0.22	neutral	1.74	deleterious	-4.32	deleterious	-5.76	medium_impact	2.77	0.88	neutral	0.31	neutral	2.18	17.37	deleterious	0.3	0.45	0.35	neutral	0.63	disease	0.63	disease	0.67	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-3.55	low_impact	-0.1	medium_impact	1.18	medium_impact	0.30	0.8	15.93	14.48	0.36	N	0.41	NA	NA	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14667	14667	A	C	MI.24174	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	7	3	Y	D	Tat/Gat	0.18	0	0	probably_damaging	1	neutral	0.12	neutral	1.72	deleterious	-4.29	deleterious	-7.31	medium_impact	3.47	0.81	neutral	0.1	damaging	3.36	22.90	deleterious	0.21	0.45	0.8	disease	0.74	disease	0.71	disease	0.75	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.81	deleterious	-3.55	low_impact	-0.27	medium_impact	1.77	medium_impact	0.37	0.8	15.93	14.48	0.29	N	0.82	NA	NA	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14667	14667	A	G	MI.24175	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	7	3	Y	H	Tat/Cat	0.18	0	0	probably_damaging	1	neutral	0.31	neutral	1.73	deleterious	-4.85	deleterious	-3.43	medium_impact	3.47	0.82	neutral	0.12	damaging	1.55	13.58	neutral	0.39	0.5	0.63	disease	0.59	disease	0.64	disease	0.59	disease	2	1	deleterious	0.16	neutral	1	deleterious	0.78	deleterious	-3.55	low_impact	0.01	medium_impact	1.77	medium_impact	0.38	0.8	15.93	14.48	0.31	N	0.61	NA	NA	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14668	14668	C	A	MI.24176	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	6	2	M	I	atG/atT	0.87	0	0.48	benign	0.02	neutral	0.56	neutral	2.3	neutral	-0.28	neutral	-0.72	low_impact	0.92	0.89	neutral	0.94	neutral	0.54	7.73	deleterious	0.64	0.7	0.11	neutral	0.2	neutral	0.17	neutral	0.36	neutral	3	0.41	neutral	0.77	deleterious	-6	neutral	0.11	neutral	0.75	medium_impact	0.27	medium_impact	-0.37	medium_impact	0.68	0.85	41.59	7.23	0.45	N	0.13	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14668	14668	C	G	MI.24177	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	6	2	M	I	atG/atC	0.87	0	0.48	benign	0.02	neutral	0.56	neutral	2.3	neutral	-0.28	neutral	-0.72	low_impact	0.92	0.89	neutral	0.94	neutral	0.20	4.70	deleterious	0.64	0.7	0.11	neutral	0.2	neutral	0.17	neutral	0.36	neutral	3	0.41	neutral	0.77	deleterious	-6	neutral	0.11	neutral	0.75	medium_impact	0.27	medium_impact	-0.37	medium_impact	0.68	0.85	41.59	7.23	0.43	N	0.13	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14669	14669	A	G	MI.24178	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	5	2	M	T	aTg/aCg	-5.55	0	0	benign	0	neutral	0.96	neutral	2.38	deleterious	-3.75	neutral	0.3	neutral_impact	-0.02	0.98	neutral	1	neutral	-1.82	0.00	neutral	0.62	0.65	0.09	neutral	0.07	neutral	0.15	neutral	0.23	neutral	5	0.03	neutral	0.98	deleterious	-6	neutral	0.07	neutral	1.95	medium_impact	0.97	medium_impact	-1.16	low_impact	0.44	0.8	41.59	7.23	0.47	N	0.04	NA	NA	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14669	14669	A	T	MI.24179	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	5	2	M	K	aTg/aAg	-5.55	0	0	benign	0.06	neutral	1	neutral	2.24	deleterious	-4.83	deleterious	-2.62	medium_impact	2.08	0.82	neutral	0.49	neutral	1.34	12.46	neutral	0.39	0.5	0.28	neutral	0.54	disease	0.4	neutral	0.53	disease	1	0.05	neutral	0.97	deleterious	-3	neutral	0.17	neutral	0.3	medium_impact	1.87	high_impact	0.6	medium_impact	0.67	0.85	41.59	7.23	0.24	N	0.32	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6154	6154	C	T	MI.2418	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	251	84	P	L	cCc/cTc	7.3	1	0	benign	0.06	deleterious	0	neutral	1.53	deleterious	-7.4	deleterious	-6.86	high_impact	4.69	0.67	neutral	0.03	damaging	4.31	24.00	deleterious	0.21	0.55	0.72	disease	0.91	disease	0.63	disease	0.74	disease	5	1	deleterious	0.47	deleterious	2	deleterious	0.34	neutral	0.37	medium_impact	-1.48	low_impact	3.23	high_impact	0.84	0.9	2.92	6.76	0.51	P	0.87	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14670	14670	T	A	MI.24180	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	4	2	M	L	Atg/Ttg	-0.5	0	0	benign	0.01	neutral	0.69	neutral	2.32	neutral	-0.8	neutral	-0.65	low_impact	1.78	0.92	neutral	0.91	neutral	0.34	6.09	deleterious	0.56	0.6	0.1	neutral	0.31	neutral	0.33	neutral	0.45	neutral	1	0.29	neutral	0.84	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	0.4	medium_impact	0.35	medium_impact	0.70	0.85	41.59	7.23	0.34	N	0.11	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14670	14670	T	G	MI.24181	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	4	2	M	L	Atg/Ctg	-0.5	0	0	benign	0.01	neutral	0.69	neutral	2.32	neutral	-0.8	neutral	-0.65	low_impact	1.78	0.92	neutral	0.91	neutral	0.22	4.85	deleterious	0.56	0.6	0.1	neutral	0.31	neutral	0.33	neutral	0.45	neutral	1	0.29	neutral	0.84	deleterious	-6	neutral	0.10	neutral	1.03	medium_impact	0.4	medium_impact	0.35	medium_impact	0.70	0.85	41.59	7.23	0.33	N	0.11	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14670	14670	T	C	MI.24182	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	4	2	M	V	Atg/Gtg	-0.5	0	0	benign	0	neutral	0.52	neutral	2.34	neutral	-1.55	neutral	-0.34	low_impact	0.83	0.93	neutral	0.94	neutral	-1.09	0.01	neutral	0.71	0.75	0.12	neutral	0.22	neutral	0.18	neutral	0.35	neutral	3	0.48	neutral	0.76	deleterious	-6	neutral	0.09	neutral	1.95	medium_impact	0.23	medium_impact	-0.45	medium_impact	0.75	0.85	41.59	7.23	0.39	N	0.09	NA	NA	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14671	14671	C	G	MI.24183	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	3	1	M	I	atG/atC	-0.5	0	0	probably_damaging	0.96	deleterious	0	neutral	1.77	neutral	-2.02	deleterious	-3.31	NA	NA	0.83	neutral	0.08	damaging	3.52	23.10	deleterious	0.38	0.5	0.38	neutral	0.52	disease	0.62	disease	0.66	disease	3	1	deleterious	0.02	neutral	4	deleterious	0.77	deleterious	NA	NA	NA	NA	NA	NA	0.62	0.8	50	8.74	0.27	N	0.75	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14671	14671	C	A	MI.24184	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	3	1	M	I	atG/atT	-0.5	0	0	probably_damaging	0.96	deleterious	0	neutral	1.77	neutral	-2.02	deleterious	-3.31	NA	NA	0.83	neutral	0.08	damaging	4.05	23.70	deleterious	0.38	0.5	0.38	neutral	0.52	disease	0.62	disease	0.66	disease	3	1	deleterious	0.02	neutral	4	deleterious	0.77	deleterious	NA	NA	NA	NA	NA	NA	0.62	0.8	50	8.74	0.27	N	0.75	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14672	14672	A	T	MI.24185	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	2	1	M	K	aTg/aAg	3.17	0.99	0	probably_damaging	0.98	deleterious	0	neutral	1.66	deleterious	-5.05	deleterious	-5.25	NA	NA	0.77	neutral	0.06	damaging	3.40	23.00	deleterious	0.21	0.45	0.62	disease	0.66	disease	0.71	disease	0.72	disease	4	1	deleterious	0.01	neutral	4	deleterious	0.83	deleterious	NA	NA	NA	NA	NA	NA	0.43	0.8	50	8.74	0.42	N	0.91	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14672	14672	A	G	MI.24186	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	2	1	M	T	aTg/aCg	3.17	0.99	0	probably_damaging	0.98	deleterious	0	neutral	1.67	deleterious	-4.17	deleterious	-4.67	NA	NA	0.76	neutral	0.05	damaging	2.92	21.90	deleterious	0.27	0.45	0.4	neutral	0.54	disease	0.68	disease	0.68	disease	4	1	deleterious	0.01	neutral	4	deleterious	0.79	deleterious	NA	NA	NA	NA	NA	NA	0.46	0.8	50	8.74	0.44	N	0.61	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14673	14673	T	A	MI.24187	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	1	1	M	L	Atg/Ttg	5	1	0	probably_damaging	0.92	deleterious	0	neutral	1.89	neutral	0.37	neutral	-2.48	NA	NA	0.83	neutral	0.15	damaging	3.37	22.90	deleterious	0.26	0.45	0.28	neutral	0.48	neutral	0.62	disease	0.51	disease	0	1	deleterious	0.04	neutral	4	deleterious	0.71	deleterious	NA	NA	NA	NA	NA	NA	0.48	0.8	50	8.74	0.53	P	0.68	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14673	14673	T	C	MI.24188	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	1	1	M	V	Atg/Gtg	5	1	0	probably_damaging	0.96	deleterious	0	neutral	1.75	neutral	-2.32	deleterious	-3.28	NA	NA	0.75	neutral	0.05	damaging	2.30	18.18	deleterious	0.37	0.5	0.37	neutral	0.48	neutral	0.69	disease	0.54	disease	1	1	deleterious	0.02	neutral	4	deleterious	0.75	deleterious	NA	NA	NA	NA	NA	NA	0.69	0.85	50	8.74	0.53	P	0.75	NA	NA	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14673	14673	T	G	MI.24189	MT-ND6	I	ENSG00000198695	ENSP00000354665	ENST00000361681	NU6M_HUMAN	P03923	4541	YP_003024037.1	1	1	M	L	Atg/Ctg	5	1	0	probably_damaging	0.92	deleterious	0	neutral	1.89	neutral	0.37	neutral	-2.48	NA	NA	0.83	neutral	0.15	damaging	3.22	22.70	deleterious	0.26	0.45	0.28	neutral	0.48	neutral	0.62	disease	0.51	disease	0	1	deleterious	0.04	neutral	4	deleterious	0.71	deleterious	NA	NA	NA	NA	NA	NA	0.48	0.8	50	8.74	0.44	N	0.68	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6154	6154	C	G	MI.2419	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	251	84	P	R	cCc/cGc	7.3	1	0	probably_damaging	0.96	deleterious	0	neutral	1.52	deleterious	-7.63	deleterious	-6.17	high_impact	5.24	0.66	neutral	0.03	damaging	3.54	23.10	deleterious	0.13	0.55	0.84	disease	0.94	disease	0.76	disease	0.87	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-2.06	low_impact	-1.48	low_impact	3.74	high_impact	0.61	0.9	2.92	6.76	0.57	P	0.90	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8640	8640	C	A	MI.242	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	114	38	I	M	atC/atA	2.9	0.15	0	probably_damaging	1	neutral	0.44	neutral	4.28	neutral	-1.39	neutral	-1.66	low_impact	1.73	0.93	neutral	0.88	neutral	2.56	19.88	deleterious	0.63	0.7	0.54	disease	0.31	neutral	0.29	neutral	0.58	disease	2	0.99	deleterious	0.22	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.23	medium_impact	0.39	medium_impact	0.70	0.9	15.49	18.25	0.4	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6154	6154	C	A	MI.2420	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	251	84	P	H	cCc/cAc	7.3	1	0	probably_damaging	0.97	deleterious	0	neutral	1.52	deleterious	-8.6	deleterious	-6.17	high_impact	4.89	0.68	neutral	0.02	damaging	3.91	23.50	deleterious	0.16	0.55	0.91	disease	0.9	disease	0.67	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.18	low_impact	-1.48	low_impact	3.42	high_impact	0.65	0.9	2.92	6.76	0.61	P	0.81	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6156	6156	C	G	MI.2421	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	253	85	L	V	Cta/Gta	-14.91	0	0	probably_damaging	0.98	neutral	0.05	neutral	2.68	neutral	-2.44	neutral	-1.95	medium_impact	3.38	0.54	damaging	0.05	damaging	3.33	22.90	deleterious	0.41	0.55	0.48	neutral	0.76	disease	0.31	neutral	0.57	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.78	deleterious	-2.35	low_impact	-0.52	medium_impact	2.02	high_impact	0.75	0.9	3.12	6.64	0.28	N	0.66	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6156	6156	C	A	MI.2422	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	253	85	L	M	Cta/Ata	-14.91	0	0	probably_damaging	1	neutral	0.09	neutral	2.65	deleterious	-3.17	neutral	-1.21	medium_impact	2.3	0.51	damaging	0.11	damaging	2.58	19.99	deleterious	0.31	0.55	0.68	disease	0.62	disease	0.25	neutral	0.47	neutral	1	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.37	medium_impact	1.03	medium_impact	0.84	0.9	3.12	6.64	0.34	N	0.59	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6157	6157	T	G	MI.2423	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	254	85	L	R	cTa/cGa	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.78	deleterious	-3.16	deleterious	-4.05	high_impact	5	0.53	damaging	0.04	damaging	4.06	23.70	deleterious	0.13	0.55	0.83	disease	0.95	disease	0.71	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.49	0.9	3.12	6.64	0.62	P	0.90	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6157	6157	T	A	MI.2424	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	254	85	L	Q	cTa/cAa	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-3.77	deleterious	-4.02	high_impact	5	0.55	damaging	0.05	damaging	3.98	23.60	deleterious	0.14	0.55	0.66	disease	0.86	disease	0.59	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.77	0.9	3.12	6.64	0.62	P	0.82	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6157	6157	T	C	MI.2425	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	254	85	L	P	cTa/cCa	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-4.99	deleterious	-4.73	high_impact	4.32	0.45	damaging	0.04	damaging	3.81	23.40	deleterious	0.16	0.55	0.88	disease	0.89	disease	0.72	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	2.89	high_impact	0.59	0.9	3.12	6.64	0.35	N	0.83	disease_causing	0.99	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6159	6159	A	G	MI.2426	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	256	86	M	V	Ata/Gta	-2.65	0	0	probably_damaging	0.97	deleterious	0	neutral	2.87	neutral	-1.15	deleterious	-2.71	high_impact	4.68	0.6	damaging	0.09	damaging	2.74	21.10	deleterious	0.44	0.55	0.44	neutral	0.88	disease	0.69	disease	0.77	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-2.18	low_impact	-1.48	low_impact	3.22	high_impact	0.67	0.9	1.95	6.66	0.5	N	0.88	polymorphism	0.92	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6159	6159	A	T	MI.2427	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	256	86	M	L	Ata/Tta	-2.65	0	0	probably_damaging	0.95	neutral	0.11	neutral	2.99	neutral	-0.03	neutral	-1.99	medium_impact	2.31	0.64	neutral	0.07	damaging	3.29	22.80	deleterious	0.4	0.55	0.32	neutral	0.75	disease	0.41	neutral	0.51	disease	0	0.98	neutral	0.08	neutral	1	deleterious	0.73	deleterious	-1.96	low_impact	-0.31	medium_impact	1.03	medium_impact	0.64	0.9	1.95	6.66	0.27	N	0.61	polymorphism	0.93	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6159	6159	A	C	MI.2428	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	256	86	M	L	Ata/Cta	-2.65	0	0	probably_damaging	0.95	neutral	0.11	neutral	2.99	neutral	-0.03	neutral	-1.99	medium_impact	2.31	0.64	neutral	0.07	damaging	3.18	22.70	deleterious	0.4	0.55	0.32	neutral	0.75	disease	0.41	neutral	0.51	disease	0	0.98	neutral	0.08	neutral	1	deleterious	0.73	deleterious	-1.96	low_impact	-0.31	medium_impact	1.03	medium_impact	0.64	0.9	1.95	6.66	0.27	N	0.61	polymorphism	0.93	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6160	6160	T	C	MI.2429	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	257	86	M	T	aTa/aCa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.88	neutral	-1.02	deleterious	-4.1	high_impact	4.22	0.63	neutral	0.11	damaging	2.94	22.00	deleterious	0.28	0.55	0.45	neutral	0.9	disease	0.68	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.8	high_impact	0.35	0.9	1.95	6.66	0.49	P	0.79	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8640	8640	C	G	MI.243	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	114	38	I	M	atC/atG	2.9	0.15	0	probably_damaging	1	neutral	0.44	neutral	4.28	neutral	-1.39	neutral	-1.66	low_impact	1.73	0.93	neutral	0.88	neutral	2.08	16.74	deleterious	0.63	0.7	0.54	disease	0.31	neutral	0.29	neutral	0.58	disease	2	0.99	deleterious	0.22	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.23	medium_impact	0.39	medium_impact	0.70	0.9	15.49	18.25	0.4	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6160	6160	T	A	MI.2430	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	257	86	M	K	aTa/aAa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-2.38	deleterious	-4.12	high_impact	5.03	0.57	damaging	0.06	damaging	4.00	23.60	deleterious	0.14	0.55	0.4	neutral	0.94	disease	0.75	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.55	high_impact	0.59	0.9	1.95	6.66	0.68	P	0.93	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6161	6161	A	T	MI.2431	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	258	86	M	I	atA/atT	5.91	1	0	probably_damaging	0.98	deleterious	0	neutral	2.84	neutral	-1.6	deleterious	-2.7	high_impact	3.71	0.52	damaging	0.1	damaging	3.39	23.00	deleterious	0.4	0.55	0.5	disease	0.87	disease	0.46	neutral	0.51	disease	0	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	2.33	high_impact	0.73	0.9	1.95	6.66	0.51	P	0.87	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6161	6161	A	C	MI.2432	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	258	86	M	I	atA/atC	5.91	1	0	probably_damaging	0.98	deleterious	0	neutral	2.84	neutral	-1.6	deleterious	-2.7	high_impact	3.71	0.52	damaging	0.1	damaging	3.33	22.90	deleterious	0.4	0.55	0.5	disease	0.87	disease	0.46	neutral	0.51	disease	0	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	2.33	high_impact	0.73	0.9	1.95	6.66	0.51	P	0.87	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6162	6162	A	G	MI.2433	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	259	87	I	V	Atc/Gtc	0.36	0.98	0	probably_damaging	0.92	deleterious	0.04	neutral	2.7	neutral	-1.61	neutral	-0.67	medium_impact	2.63	0.65	neutral	0.15	damaging	2.91	21.90	deleterious	0.63	0.65	0.34	neutral	0.44	neutral	0.22	neutral	0.48	neutral	0	0.99	deleterious	0.06	neutral	5	deleterious	0.59	deleterious	-1.76	low_impact	-0.58	medium_impact	1.33	medium_impact	0.39	0.9	2.53	6.72	0.48	N	0.23	disease_causing	0.57	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6162	6162	A	C	MI.2434	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	259	87	I	L	Atc/Ctc	0.36	0.98	0	probably_damaging	0.97	neutral	0.94	neutral	2.87	neutral	-0.89	neutral	0.55	neutral_impact	-0.29	0.65	neutral	0.33	neutral	1.02	10.76	neutral	0.43	0.55	0.29	neutral	0.15	neutral	0.13	neutral	0.27	neutral	5	0.96	neutral	0.49	deleterious	-2	neutral	0.58	deleterious	-2.18	low_impact	0.86	medium_impact	-1.37	low_impact	0.72	0.9	2.53	6.72	0.4	N	0.61	disease_causing	0.76	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6162	6162	A	T	MI.2435	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	259	87	I	F	Atc/Ttc	0.36	0.98	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-3.31	neutral	-1.78	high_impact	4.3	0.62	neutral	0.1	damaging	3.68	23.30	deleterious	0.3	0.55	0.81	disease	0.77	disease	0.55	disease	0.75	disease	5	1	deleterious	0	deleterious	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.87	high_impact	0.67	0.9	2.53	6.72	0.47	N	0.85	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6163	6163	T	G	MI.2436	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	260	87	I	S	aTc/aGc	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-3.29	deleterious	-3.15	medium_impact	3.33	0.68	neutral	0.18	damaging	4.22	23.90	deleterious	0.17	0.55	0.88	disease	0.82	disease	0.55	disease	0.77	disease	5	1	deleterious	0	deleterious	5	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	1.98	medium_impact	0.46	0.9	2.53	6.72	0.45	N	0.62	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6163	6163	T	C	MI.2437	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	260	87	I	T	aTc/aCc	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-3.03	neutral	-2.47	high_impact	3.96	0.64	neutral	0.15	damaging	3.41	23.00	deleterious	0.29	0.55	0.79	disease	0.7	disease	0.54	disease	0.68	disease	4	1	deleterious	0	deleterious	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.46	0.9	2.53	6.72	0.47	P	0.76	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6163	6163	T	A	MI.2438	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	260	87	I	N	aTc/aAc	6.83	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.31	deleterious	-3.85	high_impact	3.96	0.62	neutral	0.12	damaging	4.46	24.20	deleterious	0.15	0.55	0.93	disease	0.86	disease	0.54	disease	0.82	disease	6	1	deleterious	0	deleterious	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.48	0.9	2.53	6.72	0.47	N	0.94	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6164	6164	C	A	MI.2439	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	261	87	I	M	atC/atA	5.91	1	0.03	probably_damaging	1	neutral	0.14	neutral	2.59	deleterious	-3.06	neutral	-0.53	low_impact	1.7	0.65	neutral	0.17	damaging	3.75	23.30	deleterious	0.34	0.55	0.78	disease	0.57	disease	0.2	neutral	0.51	disease	0	1	deleterious	0.07	neutral	-2	neutral	0.78	deleterious	-3.58	low_impact	-0.25	medium_impact	0.47	medium_impact	0.75	0.9	2.53	6.72	0.53	P	0.76	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8641	8641	A	C	MI.244	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	115	39	N	H	Aac/Cac	-8.89	0	0	probably_damaging	1	neutral	0.12	neutral	4.32	neutral	-1.95	deleterious	-3.24	low_impact	1.77	0.89	neutral	0.52	neutral	2.92	22.00	deleterious	0.73	0.75	0.65	disease	0.56	disease	0.34	neutral	0.5	disease	0	1	deleterious	0.06	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	-0.2	medium_impact	0.42	medium_impact	0.57	0.9	18.58	19.57	0.43	N	0.44	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6164	6164	C	G	MI.2440	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	261	87	I	M	atC/atG	5.91	1	0.03	probably_damaging	1	neutral	0.14	neutral	2.59	deleterious	-3.06	neutral	-0.53	low_impact	1.7	0.65	neutral	0.17	damaging	3.25	22.80	deleterious	0.34	0.55	0.78	disease	0.57	disease	0.2	neutral	0.51	disease	0	1	deleterious	0.07	neutral	-2	neutral	0.78	deleterious	-3.58	low_impact	-0.25	medium_impact	0.47	medium_impact	0.75	0.9	2.53	6.72	0.52	P	0.76	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6165	6165	G	T	MI.2441	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	262	88	G	C	Ggt/Tgt	-1.72	0	0	probably_damaging	1	deleterious	0.01	neutral	2.45	deleterious	-6.39	deleterious	-6.21	high_impact	3.92	0.4	damaging	0.01	damaging	4.03	23.60	deleterious	0.18	0.55	0.96	disease	0.9	disease	0.53	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-0.92	medium_impact	2.52	high_impact	0.31	0.9	2.14	6.64	0.36	N	0.98	disease_causing	0.97	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6165	6165	G	C	MI.2442	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	262	88	G	R	Ggt/Cgt	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.73	deleterious	-5.52	high_impact	5.08	0.45	damaging	0.01	damaging	3.82	23.40	deleterious	0.18	0.55	0.78	disease	0.92	disease	0.74	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.63	0.9	2.14	6.64	0.61	P	0.95	disease_causing	0.95	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6165	6165	G	A	MI.2443	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	262	88	G	S	Ggt/Agt	-1.72	0	0	probably_damaging	1	deleterious	0.02	neutral	2.54	neutral	-2.75	deleterious	-4.07	medium_impact	2.45	0.47	damaging	0.02	damaging	4.01	23.60	deleterious	0.23	0.55	0.81	disease	0.81	disease	0.44	neutral	0.59	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-0.75	medium_impact	1.16	medium_impact	0.59	0.9	2.14	6.64	0.29	N	0.73	disease_causing	0.9	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6166	6166	G	A	MI.2444	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	263	88	G	D	gGt/gAt	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.79	deleterious	-4.82	high_impact	4.53	0.36	damaging	0.01	damaging	3.67	23.30	deleterious	0.17	0.55	0.82	disease	0.89	disease	0.72	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.08	high_impact	0.40	0.9	2.14	6.64	0.69	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6166	6166	G	C	MI.2445	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	263	88	G	A	gGt/gCt	5.22	1	0	probably_damaging	1	deleterious	0.01	neutral	2.5	deleterious	-3.49	deleterious	-4.1	medium_impact	3.45	0.59	damaging	0.08	damaging	3.09	22.50	deleterious	0.23	0.55	0.8	disease	0.77	disease	0.58	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-0.92	medium_impact	2.09	high_impact	0.52	0.9	2.14	6.64	0.41	N	0.64	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6166	6166	G	T	MI.2446	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	263	88	G	V	gGt/gTt	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.47	deleterious	-4.69	deleterious	-6.22	high_impact	4.38	0.48	damaging	0.02	damaging	3.76	23.30	deleterious	0.16	0.55	0.91	disease	0.91	disease	0.62	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.39	0.9	2.14	6.64	0.46	N	0.93	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6168	6168	G	T	MI.2447	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	265	89	A	S	Gcc/Tcc	-7.51	0	0	probably_damaging	1	neutral	0.11	neutral	2.74	neutral	-2.19	neutral	-1.85	low_impact	1.56	0.58	damaging	0.23	damaging	3.60	23.20	deleterious	0.26	0.55	0.27	neutral	0.65	disease	0.22	neutral	0.42	neutral	2	1	deleterious	0.06	neutral	-2	neutral	0.76	deleterious	-3.58	low_impact	-0.31	medium_impact	0.34	medium_impact	0.61	0.9	6.04	10.67	0.37	N	0.64	polymorphism	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6168	6168	G	A	MI.2448	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	265	89	A	T	Gcc/Acc	-7.51	0	0	probably_damaging	1	deleterious	0.01	neutral	2.79	neutral	-2.81	deleterious	-2.5	medium_impact	3.31	0.61	neutral	0.17	damaging	4.13	23.80	deleterious	0.27	0.55	0.64	disease	0.8	disease	0.4	neutral	0.54	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-0.92	medium_impact	1.96	medium_impact	0.61	0.9	6.04	10.67	0.3	N	0.20	polymorphism	0.96	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6168	6168	G	C	MI.2449	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	265	89	A	P	Gcc/Ccc	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-4.5	deleterious	-3.34	high_impact	4.89	0.56	damaging	0.13	damaging	3.78	23.40	deleterious	0.13	0.55	0.81	disease	0.86	disease	0.55	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.63	0.9	6.04	10.67	0.64	P	0.85	polymorphism	0.88	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8641	8641	A	T	MI.245	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	115	39	N	Y	Aac/Tac	-8.89	0	0	probably_damaging	1	neutral	0.2	neutral	4.31	neutral	-2.39	deleterious	-5.11	medium_impact	2.54	0.89	neutral	0.46	neutral	3.52	23.10	deleterious	0.5	0.65	0.64	disease	0.7	disease	0.49	neutral	0.51	disease	0	1	deleterious	0.1	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.05	medium_impact	1.08	medium_impact	0.49	0.9	18.58	19.57	0.41	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6169	6169	C	G	MI.2450	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	266	89	A	G	gCc/gGc	7.53	1	0	probably_damaging	0.99	deleterious	0.03	neutral	2.68	deleterious	-3.57	deleterious	-2.69	high_impact	3.8	0.61	neutral	0.16	damaging	3.92	23.50	deleterious	0.21	0.55	0.66	disease	0.67	disease	0.53	disease	0.51	disease	0	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-0.65	medium_impact	2.41	high_impact	0.66	0.9	6.04	10.67	0.52	P	0.56	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6169	6169	C	A	MI.2451	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	266	89	A	D	gCc/gAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-3.28	deleterious	-3.96	high_impact	4.55	0.65	neutral	0.12	damaging	4.39	24.10	deleterious	0.12	0.55	0.74	disease	0.88	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.50	0.9	6.04	10.67	0.55	P	0.89	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6169	6169	C	T	MI.2452	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	266	89	A	V	gCc/gTc	7.53	1	0	probably_damaging	1	neutral	0.05	neutral	2.75	deleterious	-3.36	deleterious	-2.62	medium_impact	2.66	0.49	damaging	0.14	damaging	4.41	24.10	deleterious	0.2	0.55	0.59	disease	0.82	disease	0.31	neutral	0.63	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.82	deleterious	-3.58	low_impact	-0.52	medium_impact	1.36	medium_impact	0.68	0.9	6.04	10.67	0.55	P	0.75	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6171	6171	C	G	MI.2453	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	268	90	P	A	Ccc/Gcc	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-2.33	deleterious	-5.45	medium_impact	3.34	0.68	neutral	0.06	damaging	3.03	22.30	deleterious	0.32	0.55	0.42	neutral	0.75	disease	0.58	disease	0.62	disease	2	1	deleterious	0	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	1.99	medium_impact	0.74	0.9	2.92	8.39	0.25	N	0.76	polymorphism	0.96	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6171	6171	C	T	MI.2454	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	268	90	P	S	Ccc/Tcc	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	2.86	neutral	-1.08	deleterious	-5.49	high_impact	3.68	0.68	neutral	0.04	damaging	3.84	23.40	deleterious	0.46	0.55	0.35	neutral	0.83	disease	0.55	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.3	high_impact	0.31	0.9	2.92	8.39	0.27	N	0.85	polymorphism	0.93	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6171	6171	C	A	MI.2455	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	268	90	P	T	Ccc/Acc	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-2.59	deleterious	-5.5	high_impact	4.41	0.69	neutral	0.04	damaging	3.63	23.20	deleterious	0.31	0.55	0.36	neutral	0.86	disease	0.65	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.70	0.9	2.92	8.39	0.37	N	0.80	polymorphism	0.94	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6172	6172	C	A	MI.2456	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	269	90	P	H	cCc/cAc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.75	neutral	-2.94	deleterious	-6.22	high_impact	5.1	0.68	neutral	0.02	damaging	3.92	23.50	deleterious	0.31	0.55	0.61	disease	0.88	disease	0.76	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.61	high_impact	0.66	0.9	2.92	8.39	0.71	P	0.81	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6172	6172	C	G	MI.2457	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	269	90	P	R	cCc/cGc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.94	neutral	-0.34	deleterious	-6.2	high_impact	3.75	0.66	neutral	0.03	damaging	3.54	23.10	deleterious	0.24	0.55	0.17	neutral	0.92	disease	0.77	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.36	high_impact	0.66	0.9	2.92	8.39	0.51	P	0.90	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6172	6172	C	T	MI.2458	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	269	90	P	L	cCc/cTc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-3.89	deleterious	-6.9	high_impact	4.55	0.69	neutral	0.02	damaging	4.32	24.00	deleterious	0.35	0.55	0.56	disease	0.88	disease	0.65	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.82	0.9	2.92	8.39	0.53	P	0.87	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6174	6174	G	C	MI.2459	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	271	91	D	H	Gat/Cat	-11.44	0	0	probably_damaging	0.99	deleterious	0	neutral	2.18	deleterious	-4.62	deleterious	-4.98	high_impact	5.24	0.59	damaging	0.1	damaging	3.66	23.20	deleterious	0.25	0.55	0.85	disease	0.86	disease	0.82	disease	0.86	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.64	low_impact	-1.48	low_impact	3.74	high_impact	0.54	0.9	1.56	8.43	0.66	P	0.97	polymorphism	0.82	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8641	8641	A	G	MI.246	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	115	39	N	D	Aac/Gac	-8.89	0	0	probably_damaging	0.99	neutral	0.15	neutral	4.35	neutral	-0.84	deleterious	-2.68	low_impact	1.77	0.93	neutral	0.85	neutral	2.56	19.85	deleterious	0.82	0.85	0.33	neutral	0.5	disease	0.41	neutral	0.47	neutral	1	0.99	deleterious	0.08	neutral	-2	neutral	0.69	deleterious	-2.65	low_impact	-0.13	medium_impact	0.42	medium_impact	0.63	0.9	18.58	19.57	0.46	N	0.61	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6174	6174	G	T	MI.2460	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	271	91	D	Y	Gat/Tat	-11.44	0	0	probably_damaging	0.99	deleterious	0	neutral	2.16	deleterious	-5.9	deleterious	-6.41	high_impact	5.24	0.51	damaging	0.13	damaging	3.90	23.50	deleterious	0.17	0.55	0.91	disease	0.91	disease	0.78	disease	0.86	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-2.64	low_impact	-1.48	low_impact	3.74	high_impact	0.41	0.9	1.56	8.43	0.57	P	0.94	polymorphism	0.69	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6174	6174	G	A	MI.2461	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	271	91	D	N	Gat/Aat	-11.44	0	0	possibly_damaging	0.77	deleterious	0	neutral	2.22	deleterious	-3.36	deleterious	-3.56	high_impact	4.69	0.48	damaging	0.11	damaging	4.14	23.80	deleterious	0.45	0.55	0.66	disease	0.8	disease	0.75	disease	0.77	disease	5	1	deleterious	0.12	neutral	5	deleterious	0.77	deleterious	-1.25	low_impact	-1.48	low_impact	3.23	high_impact	0.79	0.9	1.56	8.43	0.57	P	0.89	polymorphism	0.96	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6175	6175	A	C	MI.2462	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	272	91	D	A	gAt/gCt	7.3	1	0	possibly_damaging	0.67	deleterious	0	neutral	2.21	deleterious	-3.64	deleterious	-5.7	high_impact	4.89	0.67	neutral	0.13	damaging	3.67	23.20	deleterious	0.21	0.55	0.73	disease	0.84	disease	0.75	disease	0.78	disease	6	1	deleterious	0.17	neutral	5	deleterious	0.75	deleterious	-1.05	low_impact	-1.48	low_impact	3.42	high_impact	0.51	0.9	1.56	8.43	0.68	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6175	6175	A	T	MI.2463	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	272	91	D	V	gAt/gTt	7.3	1	0	benign	0.14	deleterious	0	neutral	2.17	deleterious	-5.03	deleterious	-6.41	high_impact	5.24	0.53	damaging	0.12	damaging	3.82	23.40	deleterious	0.2	0.55	0.86	disease	0.93	disease	0.75	disease	0.85	disease	7	1	deleterious	0.43	neutral	2	deleterious	0.41	neutral	-0.01	medium_impact	-1.48	low_impact	3.74	high_impact	0.31	0.9	1.56	8.43	0.58	P	0.93	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6175	6175	A	G	MI.2464	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	272	91	D	G	gAt/gGt	7.3	1	0	possibly_damaging	0.75	deleterious	0	neutral	2.18	deleterious	-4.44	deleterious	-4.98	high_impact	5.24	0.54	damaging	0.13	damaging	4.01	23.60	deleterious	0.25	0.55	0.76	disease	0.84	disease	0.76	disease	0.8	disease	6	1	deleterious	0.13	neutral	5	deleterious	0.79	deleterious	-1.21	low_impact	-1.48	low_impact	3.74	high_impact	0.47	0.9	1.56	8.43	0.68	P	0.85	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6176	6176	T	G	MI.2465	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	273	91	D	E	gaT/gaG	6.83	1	0	benign	0.22	deleterious	0.04	neutral	2.29	neutral	-2.4	deleterious	-2.85	high_impact	3.69	0.52	damaging	0.12	damaging	3.84	23.40	deleterious	0.35	0.55	0.48	neutral	0.8	disease	0.66	disease	0.71	disease	4	0.95	neutral	0.41	neutral	2	deleterious	0.43	neutral	-0.24	medium_impact	-0.58	medium_impact	2.31	high_impact	0.64	0.9	1.56	8.43	0.53	P	0.65	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6176	6176	T	A	MI.2466	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	273	91	D	E	gaT/gaA	6.83	1	0	benign	0.22	deleterious	0.04	neutral	2.29	neutral	-2.4	deleterious	-2.85	high_impact	3.69	0.52	damaging	0.12	damaging	3.96	23.60	deleterious	0.35	0.55	0.48	neutral	0.8	disease	0.66	disease	0.71	disease	4	0.95	neutral	0.41	neutral	2	deleterious	0.43	neutral	-0.24	medium_impact	-0.58	medium_impact	2.31	high_impact	0.64	0.9	1.56	8.43	0.53	P	0.65	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6177	6177	A	T	MI.2467	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	274	92	M	L	Atg/Ttg	-4.96	0	0	probably_damaging	0.95	neutral	0.09	neutral	3.34	neutral	2.04	neutral	-2.14	medium_impact	3.1	0.58	damaging	0.47	neutral	3.22	22.70	deleterious	0.45	0.55	0.18	neutral	0.74	disease	0.6	disease	0.62	disease	2	0.98	deleterious	0.07	neutral	1	deleterious	0.68	deleterious	-1.96	low_impact	-0.37	medium_impact	1.76	medium_impact	0.72	0.9	2.14	6.66	0.39	N	0.61	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6177	6177	A	G	MI.2468	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	274	92	M	V	Atg/Gtg	-4.96	0	0	probably_damaging	0.97	deleterious	0	neutral	2.84	neutral	0.22	deleterious	-2.86	medium_impact	2.97	0.47	damaging	0.44	neutral	2.59	20.10	deleterious	0.48	0.55	0.17	neutral	0.83	disease	0.61	disease	0.67	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-2.18	low_impact	-1.48	low_impact	1.64	medium_impact	0.76	0.9	2.14	6.66	0.44	N	0.88	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6177	6177	A	C	MI.2469	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	274	92	M	L	Atg/Ctg	-4.96	0	0	probably_damaging	0.95	neutral	0.09	neutral	3.34	neutral	2.04	neutral	-2.14	medium_impact	3.1	0.58	damaging	0.47	neutral	3.22	22.70	deleterious	0.45	0.55	0.18	neutral	0.74	disease	0.6	disease	0.62	disease	2	0.98	deleterious	0.07	neutral	1	deleterious	0.68	deleterious	-1.96	low_impact	-0.37	medium_impact	1.76	medium_impact	0.72	0.9	2.14	6.66	0.39	N	0.61	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8642	8642	A	T	MI.247	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	116	39	N	I	aAc/aTc	1.98	0	0	probably_damaging	1	neutral	0.14	neutral	4.33	neutral	-1.6	deleterious	-5.9	low_impact	1.59	0.86	neutral	0.49	neutral	3.85	23.40	deleterious	0.5	0.65	0.59	disease	0.7	disease	0.42	neutral	0.52	disease	0	1	deleterious	0.07	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	-0.15	medium_impact	0.27	medium_impact	0.33	0.9	18.58	19.57	0.34	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6178	6178	T	C	MI.2470	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	275	92	M	T	aTg/aCg	8.69	1	0	probably_damaging	1	deleterious	0.01	neutral	2.62	neutral	-2.91	deleterious	-4.29	high_impact	4.58	0.6	damaging	0.42	neutral	2.95	22.10	deleterious	0.38	0.55	0.3	neutral	0.87	disease	0.63	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-0.92	medium_impact	3.13	high_impact	0.53	0.9	2.14	6.66	0.49	P	0.79	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6178	6178	T	A	MI.2471	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	275	92	M	K	aTg/aAg	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-4.77	deleterious	-4.3	high_impact	5.13	0.56	damaging	0.42	neutral	3.88	23.50	deleterious	0.16	0.55	0.54	disease	0.91	disease	0.76	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.48	0.9	2.14	6.66	0.7	P	0.93	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6179	6179	G	C	MI.2472	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	276	92	M	I	atG/atC	7.53	1	0.04	probably_damaging	0.98	deleterious	0	neutral	2.8	neutral	-0.07	deleterious	-2.86	high_impact	4.16	0.53	damaging	0.53	neutral	3.56	23.10	deleterious	0.42	0.55	0.28	neutral	0.86	disease	0.6	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.35	low_impact	-1.48	low_impact	2.74	high_impact	0.82	0.9	2.14	6.66	0.52	P	0.87	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6179	6179	G	T	MI.2473	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	276	92	M	I	atG/atT	7.53	1	0.04	probably_damaging	0.98	deleterious	0	neutral	2.8	neutral	-0.07	deleterious	-2.86	high_impact	4.16	0.53	damaging	0.53	neutral	3.66	23.20	deleterious	0.42	0.55	0.28	neutral	0.86	disease	0.6	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.35	low_impact	-1.48	low_impact	2.74	high_impact	0.82	0.9	2.14	6.66	0.53	P	0.87	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6180	6180	G	C	MI.2474	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	277	93	A	P	Gcg/Ccg	-0.11	0.39	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.97	deleterious	-3.56	high_impact	4.58	0.5	damaging	0.15	damaging	3.75	23.30	deleterious	0.12	0.55	0.58	disease	0.83	disease	0.6	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.77	0.9	2.73	8.45	0.46	N	0.85	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6180	6180	G	T	MI.2475	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	277	93	A	S	Gcg/Tcg	-0.11	0.39	0	probably_damaging	1	neutral	0.21	neutral	2.72	neutral	-2.56	neutral	-1.97	medium_impact	2.62	0.63	neutral	0.18	damaging	3.60	23.20	deleterious	0.31	0.55	0.46	neutral	0.67	disease	0.26	neutral	0.44	neutral	1	1	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-3.58	low_impact	-0.13	medium_impact	1.32	medium_impact	0.75	0.9	2.73	8.45	0.35	N	0.64	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6180	6180	G	A	MI.2476	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	277	93	A	T	Gcg/Acg	-0.11	0.39	0	probably_damaging	1	deleterious	0.01	neutral	2.7	deleterious	-3.05	deleterious	-2.78	high_impact	4.32	0.54	damaging	0.15	damaging	4.14	23.80	deleterious	0.38	0.55	0.62	disease	0.82	disease	0.62	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-0.92	medium_impact	2.89	high_impact	0.66	0.9	2.73	8.45	0.32	N	0.20	disease_causing	0.99	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6181	6181	C	G	MI.2477	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	278	93	A	G	gCg/gGg	6.14	1	0	probably_damaging	0.99	deleterious	0	neutral	2.68	deleterious	-3.38	deleterious	-2.83	high_impact	4.16	0.45	damaging	0.19	damaging	3.86	23.50	deleterious	0.22	0.55	0.55	disease	0.7	disease	0.6	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.64	low_impact	-1.48	low_impact	2.74	high_impact	0.72	0.9	2.73	8.45	0.61	P	0.56	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6181	6181	C	T	MI.2478	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	278	93	A	V	gCg/gTg	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-2.29	deleterious	-2.89	high_impact	3.58	0.49	damaging	0.12	damaging	4.41	24.10	deleterious	0.3	0.55	0.72	disease	0.83	disease	0.62	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.21	high_impact	0.73	0.9	2.73	8.45	0.54	P	0.75	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6181	6181	C	A	MI.2479	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	278	93	A	E	gCg/gAg	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-2.52	deleterious	-3.52	high_impact	5.12	0.53	damaging	0.15	damaging	4.37	24.10	deleterious	0.11	0.55	0.41	neutral	0.84	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.52	0.9	2.73	8.45	0.72	P	0.76	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8642	8642	A	C	MI.248	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	116	39	N	T	aAc/aCc	1.98	0	0	probably_damaging	0.99	neutral	0.3	neutral	4.35	neutral	-0.69	deleterious	-3.1	neutral_impact	0.62	0.92	neutral	0.96	neutral	1.91	15.63	deleterious	0.63	0.7	0.5	neutral	0.34	neutral	0.2	neutral	0.33	neutral	3	0.99	deleterious	0.16	neutral	-2	neutral	0.68	deleterious	-2.65	low_impact	0.08	medium_impact	-0.57	medium_impact	0.51	0.9	18.58	19.57	0.41	N	0.37	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6183	6183	T	G	MI.2480	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	280	94	F	V	Ttt/Gtt	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-2.26	deleterious	-5.13	high_impact	5.2	0.75	neutral	0.07	damaging	4.00	23.60	deleterious	0.2	0.55	0.71	disease	0.89	disease	0.8	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.53	0.9	1.56	6.6	0.71	P	0.84	disease_causing	0.86	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6183	6183	T	A	MI.2481	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	280	94	F	I	Ttt/Att	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.51	deleterious	-4.41	high_impact	5.2	0.78	neutral	0.07	damaging	4.31	24.00	deleterious	0.17	0.55	0.73	disease	0.91	disease	0.79	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.61	0.9	1.56	6.6	0.73	P	0.88	disease_causing	0.75	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6183	6183	T	C	MI.2482	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	280	94	F	L	Ttt/Ctt	-2.19	0	0	probably_damaging	0.99	neutral	0.07	neutral	2.64	neutral	-1.79	deleterious	-4.41	high_impact	3.63	0.77	neutral	0.05	damaging	3.92	23.50	deleterious	0.31	0.55	0.51	disease	0.81	disease	0.77	disease	0.76	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.77	deleterious	-2.64	low_impact	-0.43	medium_impact	2.25	high_impact	0.76	0.9	1.56	6.6	0.35	N	0.83	disease_causing	0.77	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6184	6184	T	C	MI.2483	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	281	94	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-1.94	deleterious	-5.88	high_impact	5.2	0.79	neutral	0.08	damaging	4.11	23.80	deleterious	0.18	0.55	0.8	disease	0.87	disease	0.77	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.50	0.9	1.56	6.6	0.72	P	0.84	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6184	6184	T	G	MI.2484	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	281	94	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.89	deleterious	-5.88	high_impact	5.2	0.8	neutral	0.06	damaging	4.01	23.60	deleterious	0.19	0.55	0.91	disease	0.88	disease	0.81	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.41	0.9	1.56	6.6	0.69	P	0.91	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6184	6184	T	A	MI.2485	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	281	94	F	Y	tTt/tAt	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.53	neutral	-2.98	neutral	-2.12	medium_impact	2.9	0.78	neutral	0.06	damaging	4.16	23.80	deleterious	0.28	0.55	0.3	neutral	0.78	disease	0.76	disease	0.63	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-2.64	low_impact	-1.48	low_impact	1.58	medium_impact	0.70	0.9	1.56	6.6	0.47	N	0.59	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6185	6185	T	G	MI.2486	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	282	94	F	L	ttT/ttG	5.91	1	0.02	probably_damaging	0.99	neutral	0.07	neutral	2.64	neutral	-1.79	deleterious	-4.41	high_impact	3.63	0.77	neutral	0.05	damaging	4.27	23.90	deleterious	0.31	0.55	0.51	disease	0.81	disease	0.77	disease	0.76	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.77	deleterious	-2.64	low_impact	-0.43	medium_impact	2.25	high_impact	0.76	0.9	1.56	6.6	0.6	P	0.83	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6185	6185	T	A	MI.2487	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	282	94	F	L	ttT/ttA	5.91	1	0.02	probably_damaging	0.99	neutral	0.07	neutral	2.64	neutral	-1.79	deleterious	-4.41	high_impact	3.63	0.77	neutral	0.05	damaging	4.40	24.10	deleterious	0.31	0.55	0.51	disease	0.81	disease	0.77	disease	0.76	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.77	deleterious	-2.64	low_impact	-0.43	medium_impact	2.25	high_impact	0.76	0.9	1.56	6.6	0.6	P	0.83	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6186	6186	C	T	MI.2488	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	283	95	P	S	Ccc/Tcc	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.06	deleterious	-6.05	high_impact	5.26	0.69	neutral	0.44	neutral	3.83	23.40	deleterious	0.27	0.55	0.72	disease	0.84	disease	0.68	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.24	0.9	1.75	6.71	0.65	P	0.85	disease_causing	0.99	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6186	6186	C	G	MI.2489	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	283	95	P	A	Ccc/Gcc	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.89	deleterious	-6.05	high_impact	4.07	0.67	neutral	0.47	neutral	3.02	22.30	deleterious	0.22	0.55	0.68	disease	0.75	disease	0.62	disease	0.62	disease	2	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.66	high_impact	0.62	0.9	1.75	6.71	0.36	N	0.76	disease_causing	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8642	8642	A	G	MI.249	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	116	39	N	S	aAc/aGc	1.98	0	0	probably_damaging	0.99	neutral	0.65	neutral	4.42	neutral	0.31	deleterious	-2.6	neutral_impact	0.66	0.93	neutral	0.98	neutral	1.56	13.66	neutral	0.73	0.75	0.36	neutral	0.35	neutral	0.23	neutral	0.46	neutral	1	0.99	deleterious	0.33	neutral	-2	neutral	0.69	deleterious	-2.65	low_impact	0.44	medium_impact	-0.53	medium_impact	0.20	0.9	18.58	19.57	0.32	N	0.04	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6186	6186	C	A	MI.2490	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	283	95	P	T	Ccc/Acc	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-3.39	deleterious	-6.05	high_impact	5.26	0.62	neutral	0.33	neutral	3.62	23.20	deleterious	0.24	0.55	0.77	disease	0.87	disease	0.68	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.62	0.9	1.75	6.71	0.65	P	0.80	disease_causing	0.99	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6187	6187	C	A	MI.2491	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	284	95	P	H	cCc/cAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.63	deleterious	-6.81	high_impact	5.26	0.63	neutral	0.33	neutral	3.93	23.50	deleterious	0.19	0.55	0.94	disease	0.88	disease	0.79	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.47	0.9	1.75	6.71	0.7	P	0.81	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6187	6187	C	G	MI.2492	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	284	95	P	R	cCc/cGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.92	deleterious	-6.81	high_impact	5.26	0.6	damaging	0.33	neutral	3.56	23.10	deleterious	0.18	0.55	0.88	disease	0.93	disease	0.79	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.48	0.9	1.75	6.71	0.69	P	0.90	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6187	6187	C	T	MI.2493	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	284	95	P	L	cCc/cTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.99	deleterious	-7.56	high_impact	4.57	0.61	neutral	0.4	neutral	4.33	24.00	deleterious	0.25	0.55	0.8	disease	0.88	disease	0.69	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.76	0.9	1.75	6.71	0.59	P	0.87	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6189	6189	C	T	MI.2494	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	286	96	R	C	Cgc/Tgc	-11.21	0	0	probably_damaging	0.98	deleterious	0	neutral	2.37	deleterious	-6.17	deleterious	-6.14	high_impact	5.26	0.47	damaging	0.02	damaging	4.97	25.10	deleterious	0.27	0.55	0.9	disease	0.84	disease	0.78	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.35	low_impact	-1.48	low_impact	3.76	high_impact	0.76	0.9	2.14	6.67	0.53	P	1.00	disease_causing	0.97	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6189	6189	C	G	MI.2495	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	286	96	R	G	Cgc/Ggc	-11.21	0	0	possibly_damaging	0.79	deleterious	0	neutral	2.41	deleterious	-3.52	deleterious	-5.37	high_impact	4.71	0.56	damaging	0.04	damaging	4.18	23.80	deleterious	0.24	0.55	0.76	disease	0.71	disease	0.76	disease	0.77	disease	5	1	deleterious	0.11	neutral	5	deleterious	0.68	deleterious	-1.3	low_impact	-1.48	low_impact	3.25	high_impact	0.38	0.9	2.14	6.67	0.57	P	0.92	polymorphism	0.92	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6189	6189	C	A	MI.2496	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	286	96	R	S	Cgc/Agc	-11.21	0	0	possibly_damaging	0.73	deleterious	0	neutral	2.44	neutral	-2.7	deleterious	-4.6	high_impact	5.26	0.54	damaging	0.03	damaging	4.54	24.30	deleterious	0.24	0.55	0.62	disease	0.79	disease	0.75	disease	0.77	disease	5	1	deleterious	0.14	neutral	5	deleterious	0.68	deleterious	-1.16	low_impact	-1.48	low_impact	3.76	high_impact	0.42	0.9	2.14	6.67	0.59	P	0.80	polymorphism	0.92	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6190	6190	G	A	MI.2497	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	287	96	R	H	cGc/cAc	3.6	0.99	0	benign	0.04	deleterious	0	neutral	2.39	deleterious	-4.29	deleterious	-3.84	high_impact	5.26	0.55	damaging	0.03	damaging	4.35	24.10	deleterious	0.42	0.55	0.75	disease	0.78	disease	0.71	disease	0.74	disease	5	1	deleterious	0.48	deleterious	2	deleterious	0.29	neutral	0.54	medium_impact	-1.48	low_impact	3.76	high_impact	0.80	0.9	2.14	6.67	0.62	P	0.98	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6190	6190	G	T	MI.2498	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	287	96	R	L	cGc/cTc	3.6	0.99	0	possibly_damaging	0.63	deleterious	0	neutral	2.41	deleterious	-3.48	deleterious	-5.37	high_impact	4.92	0.6	damaging	0.02	damaging	4.29	24.00	deleterious	0.23	0.55	0.63	disease	0.87	disease	0.75	disease	0.8	disease	6	1	deleterious	0.19	neutral	5	deleterious	0.63	deleterious	-0.97	medium_impact	-1.48	low_impact	3.44	high_impact	0.30	0.9	2.14	6.67	0.66	P	0.99	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6190	6190	G	C	MI.2499	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	287	96	R	P	cGc/cCc	3.6	0.99	0	probably_damaging	0.92	deleterious	0	neutral	2.39	deleterious	-4.14	deleterious	-5.37	high_impact	5.26	0.4	damaging	0.04	damaging	4.22	23.90	deleterious	0.2	0.55	0.81	disease	0.84	disease	0.74	disease	0.8	disease	6	1	deleterious	0.04	neutral	6	deleterious	0.82	deleterious	-1.76	low_impact	-1.48	low_impact	3.76	high_impact	0.34	0.9	2.14	6.67	0.71	P	0.99	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8537	8537	A	T	MI.25	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	11	4	N	I	aAt/aTt	5.91	1	0.01	benign	0.38	deleterious	0	neutral	4.42	neutral	-2.07	deleterious	-6.2	medium_impact	2.85	0.85	neutral	0.48	neutral	3.59	23.20	deleterious	0.42	0.65	0.53	disease	0.62	disease	0.58	disease	0.7	disease	4	1	deleterious	0.31	neutral	1	deleterious	0.48	deleterious	-0.55	medium_impact	-1.4	low_impact	1.35	medium_impact	0.37	0.9	41.59	7.51	0.64	P	0.97	disease_causing	0.99	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8643	8643	C	G	MI.250	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	117	39	N	K	aaC/aaG	-1.49	0	0	probably_damaging	0.99	neutral	0.23	neutral	4.38	neutral	-0.2	deleterious	-3.77	low_impact	1.12	0.87	neutral	0.58	neutral	3.70	23.30	deleterious	0.83	0.85	0.38	neutral	0.59	disease	0.27	neutral	0.45	neutral	1	0.99	deleterious	0.12	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	-0.01	medium_impact	-0.14	medium_impact	0.40	0.9	18.58	19.57	0.36	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6192	6192	A	T	MI.2500	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	289	97	M	L	Ata/Tta	-0.57	0.04	0	benign	0	neutral	0.57	neutral	3.33	neutral	2.72	neutral	-1.37	neutral_impact	0.28	0.57	damaging	0.81	neutral	-0.07	1.98	neutral	0.35	0.55	0.35	neutral	0.39	neutral	0.28	neutral	0.45	neutral	1	0.43	neutral	0.79	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	0.26	medium_impact	-0.84	medium_impact	0.73	0.9	12.67	45.68	0.45	N	0.01	disease_causing	0.88	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6192	6192	A	G	MI.2501	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	289	97	M	V	Ata/Gta	-0.57	0.04	0	benign	0.05	deleterious	0.03	neutral	2.82	neutral	0.1	neutral	-2.34	medium_impact	3.09	0.59	damaging	0.46	neutral	0.85	9.76	deleterious	0.42	0.55	0.29	neutral	0.82	disease	0.58	disease	0.67	disease	3	0.97	neutral	0.49	deleterious	1	deleterious	0.22	neutral	0.45	medium_impact	-0.65	medium_impact	1.75	medium_impact	0.74	0.9	12.67	45.68	0.42	N	0.48	disease_causing	0.9	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6192	6192	A	C	MI.2502	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	289	97	M	L	Ata/Cta	-0.57	0.04	0	benign	0	neutral	0.57	neutral	3.33	neutral	2.72	neutral	-1.37	neutral_impact	0.28	0.57	damaging	0.81	neutral	-0.18	1.23	neutral	0.35	0.55	0.35	neutral	0.39	neutral	0.28	neutral	0.45	neutral	1	0.43	neutral	0.79	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	0.26	medium_impact	-0.84	medium_impact	0.73	0.9	12.67	45.68	0.44	N	0.01	disease_causing	0.88	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6193	6193	T	C	MI.2503	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	290	97	M	T	aTa/aCa	4.06	0.99	0	benign	0.33	deleterious	0	neutral	2.76	neutral	-0.75	deleterious	-3.94	high_impact	4.66	0.58	damaging	0.5	neutral	1.14	11.45	neutral	0.31	0.55	0.55	disease	0.88	disease	0.68	disease	0.76	disease	5	1	deleterious	0.34	neutral	2	deleterious	0.39	neutral	-0.47	medium_impact	-1.48	low_impact	3.2	high_impact	0.55	0.9	12.67	45.68	0.57	P	0.15	disease_causing	0.99	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6193	6193	T	A	MI.2504	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	290	97	M	K	aTa/aAa	4.06	0.99	0	benign	0.18	deleterious	0	neutral	2.71	neutral	-2.42	deleterious	-4.19	high_impact	4.66	0.62	neutral	0.42	neutral	2.11	16.95	deleterious	0.13	0.55	0.74	disease	0.93	disease	0.74	disease	0.82	disease	6	1	deleterious	0.41	neutral	2	deleterious	0.39	neutral	-0.14	medium_impact	-1.48	low_impact	3.2	high_impact	0.51	0.9	12.67	45.68	0.61	P	0.68	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6194	6194	A	T	MI.2505	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	291	97	M	I	atA/atT	7.53	1	0	benign	0.04	neutral	0.06	neutral	2.84	neutral	0.38	neutral	-2.18	medium_impact	3.16	0.56	damaging	0.51	neutral	1.38	12.66	neutral	0.41	0.55	0.21	neutral	0.87	disease	0.55	disease	0.68	disease	4	0.94	neutral	0.51	deleterious	-3	neutral	0.22	neutral	0.54	medium_impact	-0.47	medium_impact	1.82	medium_impact	0.84	0.9	12.67	45.68	0.59	P	0.33	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6194	6194	A	C	MI.2506	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	291	97	M	I	atA/atC	7.53	1	0	benign	0.04	neutral	0.06	neutral	2.84	neutral	0.38	neutral	-2.18	medium_impact	3.16	0.56	damaging	0.51	neutral	1.30	12.27	neutral	0.41	0.55	0.21	neutral	0.87	disease	0.55	disease	0.68	disease	4	0.94	neutral	0.51	deleterious	-3	neutral	0.22	neutral	0.54	medium_impact	-0.47	medium_impact	1.82	medium_impact	0.84	0.9	12.67	45.68	0.58	P	0.33	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6195	6195	A	C	MI.2507	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	292	98	N	H	Aac/Cac	2.67	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-4.17	deleterious	-3.87	high_impact	5.27	0.57	damaging	0.04	damaging	3.01	22.30	deleterious	0.3	0.55	0.89	disease	0.72	disease	0.81	disease	0.83	disease	7	1	deleterious	0	deleterious	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.48	0.9	2.73	6.71	0.66	P	0.83	disease_causing	0.99	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6195	6195	A	T	MI.2508	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	292	98	N	Y	Aac/Tac	2.67	1	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-4.69	deleterious	-6.19	high_impact	5.27	0.54	damaging	0.05	damaging	3.61	23.20	deleterious	0.25	0.55	0.91	disease	0.76	disease	0.76	disease	0.82	disease	6	1	deleterious	0	deleterious	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.49	0.9	2.73	6.71	0.58	P	0.93	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6195	6195	A	G	MI.2509	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	292	98	N	D	Aac/Gac	2.67	1	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-3.27	deleterious	-3.87	high_impact	5.27	0.47	damaging	0.06	damaging	3.77	23.40	deleterious	0.44	0.55	0.76	disease	0.63	disease	0.74	disease	0.75	disease	5	1	deleterious	0	deleterious	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.62	0.9	2.73	6.71	0.66	P	0.92	disease_causing	0.98	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8643	8643	C	A	MI.251	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	117	39	N	K	aaC/aaA	-1.49	0	0	probably_damaging	0.99	neutral	0.23	neutral	4.38	neutral	-0.2	deleterious	-3.77	low_impact	1.12	0.87	neutral	0.58	neutral	4.18	23.80	deleterious	0.83	0.85	0.38	neutral	0.59	disease	0.27	neutral	0.45	neutral	1	0.99	deleterious	0.12	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	-0.01	medium_impact	-0.14	medium_impact	0.40	0.9	18.58	19.57	0.36	N	0.73	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6196	6196	A	G	MI.2510	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	293	98	N	S	aAc/aGc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.68	neutral	-2.32	deleterious	-3.87	high_impact	4.92	0.58	damaging	0.06	damaging	2.94	22.00	deleterious	0.43	0.55	0.59	disease	0.67	disease	0.73	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	3.44	high_impact	0.44	0.9	2.73	6.71	0.73	P	0.79	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6196	6196	A	T	MI.2511	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	293	98	N	I	aAc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.71	deleterious	-6.96	high_impact	4.12	0.59	damaging	0.05	damaging	3.76	23.30	deleterious	0.25	0.55	0.61	disease	0.87	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.44	0.9	2.73	6.71	0.5	N	0.98	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6196	6196	A	C	MI.2512	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	293	98	N	T	aAc/aCc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.86	deleterious	-4.64	high_impact	5.27	0.56	damaging	0.07	damaging	3.32	22.90	deleterious	0.33	0.55	0.76	disease	0.75	disease	0.74	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.60	0.9	2.73	6.71	0.72	P	0.59	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6197	6197	C	A	MI.2513	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	294	98	N	K	aaC/aaA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-2.28	deleterious	-4.64	high_impact	4.92	0.54	damaging	0.04	damaging	4.36	24.10	deleterious	0.4	0.55	0.76	disease	0.78	disease	0.81	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.63	0.9	2.73	6.71	0.74	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6197	6197	C	G	MI.2514	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	294	98	N	K	aaC/aaG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-2.28	deleterious	-4.64	high_impact	4.92	0.54	damaging	0.04	damaging	3.90	23.50	deleterious	0.4	0.55	0.76	disease	0.78	disease	0.81	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.63	0.9	2.73	6.71	0.74	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6198	6198	A	T	MI.2515	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	295	99	N	Y	Aac/Tac	-8.66	0	0	possibly_damaging	0.87	deleterious	0	neutral	2.74	neutral	-2.51	deleterious	-6.21	high_impact	4.82	0.62	neutral	0.05	damaging	3.42	23.00	deleterious	0.32	0.55	0.67	disease	0.73	disease	0.75	disease	0.76	disease	5	1	deleterious	0.07	neutral	5	deleterious	0.74	deleterious	-1.53	low_impact	-1.48	low_impact	3.35	high_impact	0.56	0.9	1.75	6.66	0.58	P	0.93	disease_causing	0.98	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6198	6198	A	C	MI.2516	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	295	99	N	H	Aac/Cac	-8.66	0	0	possibly_damaging	0.86	deleterious	0	neutral	2.71	deleterious	-3.94	deleterious	-3.88	high_impact	5.17	0.61	neutral	0.05	damaging	2.88	21.80	deleterious	0.42	0.55	0.64	disease	0.7	disease	0.8	disease	0.77	disease	5	1	deleterious	0.07	neutral	5	deleterious	0.72	deleterious	-1.5	low_impact	-1.48	low_impact	3.68	high_impact	0.64	0.9	1.75	6.66	0.64	P	0.83	disease_causing	0.93	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6198	6198	A	G	MI.2517	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	295	99	N	D	Aac/Gac	-8.66	0	0	benign	0.18	deleterious	0	neutral	2.7	deleterious	-4.1	deleterious	-3.88	high_impact	5.17	0.52	damaging	0.06	damaging	3.62	23.20	deleterious	0.55	0.6	0.51	disease	0.59	disease	0.79	disease	0.76	disease	5	1	deleterious	0.41	neutral	2	deleterious	0.30	neutral	-0.14	medium_impact	-1.48	low_impact	3.68	high_impact	0.71	0.9	1.75	6.66	0.57	P	0.92	disease_causing	0.86	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6199	6199	A	C	MI.2518	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	296	99	N	T	aAc/aCc	8.69	1	0	benign	0.01	neutral	0.05	neutral	2.74	neutral	-2.54	deleterious	-4.66	high_impact	4.82	0.63	neutral	0.07	damaging	3.30	22.90	deleterious	0.45	0.55	0.37	neutral	0.73	disease	0.73	disease	0.72	disease	4	0.95	neutral	0.52	deleterious	-2	neutral	0.22	neutral	1.12	medium_impact	-0.52	medium_impact	3.35	high_impact	0.64	0.9	1.75	6.66	0.66	P	0.59	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6199	6199	A	G	MI.2519	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	296	99	N	S	aAc/aGc	8.69	1	0	benign	0.06	deleterious	0.04	neutral	2.77	neutral	-2.01	deleterious	-3.88	high_impact	3.64	0.62	neutral	0.06	damaging	3.01	22.30	deleterious	0.55	0.6	0.27	neutral	0.64	disease	0.73	disease	0.7	disease	4	0.96	neutral	0.49	deleterious	2	deleterious	0.23	neutral	0.37	medium_impact	-0.58	medium_impact	2.26	high_impact	0.47	0.9	1.75	6.66	0.59	P	0.79	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8644	8644	A	G	MI.252	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	118	40	N	D	Aac/Gac	-5.66	0	0	probably_damaging	0.99	deleterious	0.03	neutral	4.3	neutral	-1.53	deleterious	-4.31	medium_impact	2.94	0.9	neutral	0.53	neutral	3.55	23.10	deleterious	0.83	0.85	0.69	disease	0.7	disease	0.49	neutral	0.49	neutral	0	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-2.65	low_impact	-0.56	medium_impact	1.42	medium_impact	0.74	0.9	48.67	8.5	0.45	N	0.97	polymorphism	0.96	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6199	6199	A	T	MI.2520	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	296	99	N	I	aAc/aTc	8.69	1	0	possibly_damaging	0.64	deleterious	0	neutral	2.76	neutral	-2.19	deleterious	-6.99	high_impact	5.17	0.63	neutral	0.05	damaging	3.92	23.50	deleterious	0.33	0.55	0.53	disease	0.85	disease	0.73	disease	0.78	disease	6	1	deleterious	0.18	neutral	5	deleterious	0.63	deleterious	-0.99	medium_impact	-1.48	low_impact	3.68	high_impact	0.42	0.9	1.75	6.66	0.65	P	0.98	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6200	6200	C	A	MI.2521	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	297	99	N	K	aaC/aaA	8.69	1	0	benign	0.39	deleterious	0	neutral	2.76	neutral	-2.21	deleterious	-4.66	high_impact	4.82	0.59	damaging	0.04	damaging	4.41	24.10	deleterious	0.59	0.65	0.39	neutral	0.74	disease	0.74	disease	0.73	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.57	deleterious	-0.57	medium_impact	-1.48	low_impact	3.35	high_impact	0.77	0.9	1.75	6.66	0.65	P	0.92	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6200	6200	C	G	MI.2522	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	297	99	N	K	aaC/aaG	8.69	1	0	benign	0.39	deleterious	0	neutral	2.76	neutral	-2.21	deleterious	-4.66	high_impact	4.82	0.59	damaging	0.04	damaging	3.88	23.50	deleterious	0.59	0.65	0.39	neutral	0.74	disease	0.74	disease	0.73	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.57	deleterious	-0.57	medium_impact	-1.48	low_impact	3.35	high_impact	0.77	0.9	1.75	6.66	0.65	P	0.92	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6201	6201	A	C	MI.2523	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	298	100	M	L	Ata/Cta	-4.04	0	0	probably_damaging	0.91	neutral	0.33	neutral	3.09	neutral	2.19	neutral	-1.38	neutral_impact	0.74	0.54	damaging	0.05	damaging	1.87	15.38	deleterious	0.4	0.55	0.24	neutral	0.59	disease	0.48	neutral	0.44	neutral	1	0.92	neutral	0.21	neutral	-2	neutral	0.60	deleterious	-1.7	low_impact	0.02	medium_impact	-0.42	medium_impact	0.59	0.9	2.92	6.72	0.25	N	0.61	disease_causing	0.8	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6201	6201	A	G	MI.2524	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	298	100	M	V	Ata/Gta	-4.04	0	0	probably_damaging	0.94	deleterious	0	neutral	2.93	neutral	1.01	neutral	-2.43	medium_impact	3.19	0.59	damaging	0.1	damaging	2.52	19.60	deleterious	0.44	0.55	0.22	neutral	0.75	disease	0.55	disease	0.53	disease	1	1	deleterious	0.03	neutral	5	deleterious	0.66	deleterious	-1.88	low_impact	-1.48	low_impact	1.85	medium_impact	0.66	0.9	2.92	6.72	0.28	N	0.88	disease_causing	0.83	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6201	6201	A	T	MI.2525	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	298	100	M	L	Ata/Tta	-4.04	0	0	probably_damaging	0.91	neutral	0.33	neutral	3.09	neutral	2.19	neutral	-1.38	neutral_impact	0.74	0.54	damaging	0.05	damaging	1.94	15.84	deleterious	0.4	0.55	0.24	neutral	0.59	disease	0.48	neutral	0.44	neutral	1	0.92	neutral	0.21	neutral	-2	neutral	0.60	deleterious	-1.7	low_impact	0.02	medium_impact	-0.42	medium_impact	0.59	0.9	2.92	6.72	0.25	N	0.61	disease_causing	0.8	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6202	6202	T	C	MI.2526	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	299	100	M	T	aTa/aCa	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.83	neutral	-0.11	deleterious	-4.02	high_impact	4.7	0.66	neutral	0.1	damaging	2.90	21.80	deleterious	0.32	0.55	0.33	neutral	0.83	disease	0.7	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	3.24	high_impact	0.38	0.9	2.92	6.72	0.57	P	0.79	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6202	6202	T	A	MI.2527	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	299	100	M	K	aTa/aAa	8.69	1	0	probably_damaging	0.98	deleterious	0	neutral	2.78	neutral	-1.68	deleterious	-4.25	high_impact	4.7	0.59	damaging	0.07	damaging	3.92	23.50	deleterious	0.17	0.55	0.52	disease	0.89	disease	0.77	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.35	low_impact	-1.48	low_impact	3.24	high_impact	0.48	0.9	2.92	6.72	0.71	P	0.93	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6203	6203	A	C	MI.2528	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	300	100	M	I	atA/atC	4.75	1	0	probably_damaging	0.96	neutral	0.13	neutral	2.94	neutral	1.73	neutral	-2.23	medium_impact	2.08	0.53	damaging	0.09	damaging	3.20	22.70	deleterious	0.38	0.55	0.2	neutral	0.61	disease	0.47	neutral	0.43	neutral	1	0.98	deleterious	0.09	neutral	1	deleterious	0.67	deleterious	-2.06	low_impact	-0.27	medium_impact	0.82	medium_impact	0.65	0.9	2.92	6.72	0.5	P	0.87	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6203	6203	A	T	MI.2529	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	300	100	M	I	atA/atT	4.75	1	0	probably_damaging	0.96	neutral	0.13	neutral	2.94	neutral	1.73	neutral	-2.23	medium_impact	2.08	0.53	damaging	0.09	damaging	3.28	22.80	deleterious	0.38	0.55	0.2	neutral	0.61	disease	0.47	neutral	0.43	neutral	1	0.98	deleterious	0.09	neutral	1	deleterious	0.67	deleterious	-2.06	low_impact	-0.27	medium_impact	0.82	medium_impact	0.65	0.9	2.92	6.72	0.5	P	0.87	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8644	8644	A	C	MI.253	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	118	40	N	H	Aac/Cac	-5.66	0	0	probably_damaging	1	deleterious	0.02	neutral	4.27	neutral	-2.58	deleterious	-4.36	medium_impact	3.29	0.8	neutral	0.31	neutral	2.81	21.40	deleterious	0.72	0.75	0.84	disease	0.77	disease	0.63	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.66	medium_impact	1.72	medium_impact	0.56	0.9	48.67	8.5	0.28	N	0.98	polymorphism	0.91	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6204	6204	A	C	MI.2530	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	301	101	S	R	Agc/Cgc	-1.03	0	0	probably_damaging	1	deleterious	0.02	neutral	2.66	deleterious	-3.3	deleterious	-3.82	high_impact	4.89	0.53	damaging	0.04	damaging	3.72	23.30	deleterious	0.18	0.55	0.86	disease	0.83	disease	0.81	disease	0.85	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-0.75	medium_impact	3.42	high_impact	0.70	0.9	2.14	6.64	0.69	P	0.98	disease_causing	0.94	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6204	6204	A	T	MI.2531	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	301	101	S	C	Agc/Tgc	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-5.33	deleterious	-3.83	high_impact	5.24	0.49	damaging	0.04	damaging	3.27	22.80	deleterious	0.22	0.55	0.87	disease	0.71	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.68	0.9	2.14	6.64	0.61	P	0.85	disease_causing	0.93	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6204	6204	A	G	MI.2532	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	301	101	S	G	Agc/Ggc	-1.03	0	0	probably_damaging	0.99	deleterious	0	neutral	2.76	neutral	-2.19	deleterious	-2.9	high_impact	3.88	0.51	damaging	0.1	damaging	3.44	23.00	deleterious	0.31	0.55	0.3	neutral	0.49	neutral	0.67	disease	0.56	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.69	deleterious	-2.64	low_impact	-1.48	low_impact	2.48	high_impact	0.74	0.9	2.14	6.64	0.39	N	0.70	disease_causing	0.76	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6205	6205	G	C	MI.2533	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	302	101	S	T	aGc/aCc	6.84	1	0	probably_damaging	0.97	deleterious	0	neutral	2.71	neutral	-2.84	neutral	-2.3	high_impact	4.54	0.51	damaging	0.08	damaging	3.27	22.80	deleterious	0.3	0.55	0.3	neutral	0.61	disease	0.67	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.69	deleterious	-2.18	low_impact	-1.48	low_impact	3.09	high_impact	0.81	0.9	2.14	6.64	0.51	P	0.43	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6205	6205	G	A	MI.2534	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	302	101	S	N	aGc/aAc	6.84	1	0	probably_damaging	0.97	deleterious	0	neutral	2.67	deleterious	-3.19	neutral	-2.3	high_impact	5.24	0.48	damaging	0.07	damaging	3.52	23.10	deleterious	0.49	0.55	0.81	disease	0.67	disease	0.72	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-2.18	low_impact	-1.48	low_impact	3.74	high_impact	0.60	0.9	2.14	6.64	0.74	P	0.66	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6205	6205	G	T	MI.2535	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	302	101	S	I	aGc/aTc	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-3.41	deleterious	-4.61	high_impact	5.24	0.53	damaging	0.07	damaging	3.98	23.60	deleterious	0.2	0.55	0.88	disease	0.87	disease	0.73	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.83	0.9	2.14	6.64	0.73	P	0.96	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6207	6207	T	G	MI.2536	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	304	102	F	V	Ttc/Gtc	-0.8	0.05	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.34	deleterious	-5.49	high_impact	4.28	0.72	neutral	0.06	damaging	4.06	23.70	deleterious	0.27	0.55	0.46	neutral	0.78	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.85	high_impact	0.65	0.9	5.46	8.29	0.45	N	0.84	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6207	6207	T	A	MI.2537	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	304	102	F	I	Ttc/Atc	-0.8	0.05	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-3.68	deleterious	-4.71	high_impact	4.02	0.74	neutral	0.07	damaging	4.35	24.10	deleterious	0.23	0.55	0.58	disease	0.8	disease	0.76	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.61	high_impact	0.74	0.9	5.46	8.29	0.42	N	0.88	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6207	6207	T	C	MI.2538	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	304	102	F	L	Ttc/Ctc	-0.8	0.05	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.39	deleterious	-4.7	medium_impact	3.31	0.75	neutral	0.05	damaging	3.97	23.60	deleterious	0.44	0.55	0.41	neutral	0.7	disease	0.68	disease	0.62	disease	2	1	deleterious	0	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-1.48	low_impact	1.96	medium_impact	0.75	0.9	5.46	8.29	0.34	N	0.83	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6208	6208	T	A	MI.2539	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	305	102	F	Y	tTc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.53	neutral	-1.6	neutral	-2.35	medium_impact	3.1	0.73	neutral	0.06	damaging	4.14	23.80	deleterious	0.26	0.55	0.37	neutral	0.67	disease	0.67	disease	0.67	disease	3	1	deleterious	0	neutral	5	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	1.76	medium_impact	0.80	0.9	5.46	8.29	0.54	P	0.59	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8644	8644	A	T	MI.254	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	118	40	N	Y	Aac/Tac	-5.66	0	0	probably_damaging	1	deleterious	0	neutral	4.27	deleterious	-3.24	deleterious	-6.8	medium_impact	3.48	0.83	neutral	0.44	neutral	3.36	22.90	deleterious	0.35	0.65	0.9	disease	0.84	disease	0.69	disease	0.78	disease	6	1	deleterious	0	neutral	5	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	1.89	medium_impact	0.52	0.9	48.67	8.5	0.32	N	1.00	polymorphism	0.72	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6208	6208	T	G	MI.2540	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	305	102	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-6.02	deleterious	-6.28	high_impact	5.17	0.74	neutral	0.05	damaging	4.02	23.60	deleterious	0.25	0.55	0.84	disease	0.79	disease	0.76	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.46	0.9	5.46	8.29	0.65	P	0.91	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6208	6208	T	C	MI.2541	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	305	102	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.47	deleterious	-4.63	deleterious	-6.28	high_impact	4.37	0.75	neutral	0.08	damaging	4.13	23.80	deleterious	0.24	0.55	0.7	disease	0.78	disease	0.74	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.94	high_impact	0.57	0.9	5.46	8.29	0.54	P	0.84	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6209	6209	C	G	MI.2542	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	306	102	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.39	deleterious	-4.7	medium_impact	3.31	0.75	neutral	0.05	damaging	4.28	24.00	deleterious	0.44	0.55	0.41	neutral	0.7	disease	0.68	disease	0.62	disease	2	1	deleterious	0	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-1.48	low_impact	1.96	medium_impact	0.75	0.9	5.46	8.29	0.54	P	0.83	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6209	6209	C	A	MI.2543	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	306	102	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.39	deleterious	-4.7	medium_impact	3.31	0.75	neutral	0.05	damaging	4.53	24.30	deleterious	0.44	0.55	0.41	neutral	0.7	disease	0.68	disease	0.62	disease	2	1	deleterious	0	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-1.48	low_impact	1.96	medium_impact	0.75	0.9	5.46	8.29	0.54	P	0.83	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6210	6210	T	G	MI.2544	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	307	103	W	G	Tga/Gga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-3.89	deleterious	-10.34	high_impact	4.57	0.64	neutral	0.12	damaging	3.81	23.40	deleterious	0.17	0.55	0.92	disease	0.69	disease	0.79	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.29	0.9	2.92	6.69	0.48	N	0.89	disease_causing	0.99	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6210	6210	T	C	MI.2545	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	307	103	W	R	Tga/Cga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.68	deleterious	-11.14	high_impact	4.57	0.65	neutral	0.1	damaging	3.49	23.10	deleterious	0.22	0.55	0.91	disease	0.84	disease	0.83	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.31	0.9	2.92	6.69	0.51	N	0.98	disease_causing	0.97	0.50	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6211	6211	G	C	MI.2546	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	308	103	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-3.88	deleterious	-11.13	high_impact	5.26	0.72	neutral	0.14	damaging	3.93	23.50	deleterious	0.16	0.55	0.86	disease	0.8	disease	0.77	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.28	0.9	2.92	6.69	0.64	P	0.89	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6211	6211	G	T	MI.2547	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	308	103	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.57	neutral	-2.66	deleterious	-10.34	high_impact	3.73	0.58	damaging	0.12	damaging	4.14	23.80	deleterious	0.15	0.55	0.57	disease	0.74	disease	0.77	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.35	high_impact	0.28	0.9	2.92	6.69	0.55	P	0.95	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6212	6212	A	C	MI.2548	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	309	103	W	C	tgA/tgC	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-5.34	deleterious	-10.34	high_impact	5.26	0.64	neutral	0.1	damaging	3.89	23.50	deleterious	0.19	0.55	0.94	disease	0.8	disease	0.82	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.31	0.9	2.92	6.69	0.62	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6212	6212	A	T	MI.2549	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	309	103	W	C	tgA/tgT	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-5.34	deleterious	-10.34	high_impact	5.26	0.64	neutral	0.1	damaging	4.02	23.60	deleterious	0.19	0.55	0.94	disease	0.8	disease	0.82	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.31	0.9	2.92	6.69	0.62	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8645	8645	A	G	MI.255	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	119	40	N	S	aAc/aGc	5.68	1	0	probably_damaging	0.99	neutral	0.85	neutral	4.45	neutral	-0.66	deleterious	-4.11	neutral_impact	0.57	0.86	neutral	0.53	neutral	2.38	18.69	deleterious	0.82	0.85	0.37	neutral	0.48	neutral	0.4	neutral	0.42	neutral	2	0.99	deleterious	0.43	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	0.72	medium_impact	-0.61	medium_impact	0.46	0.9	48.67	8.5	0.4	N	0.88	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6213	6213	C	G	MI.2550	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	310	104	L	V	Ctc/Gtc	1.98	1	0	possibly_damaging	0.5	neutral	0.07	neutral	2.57	neutral	-1.23	neutral	-2.25	high_impact	3.7	0.55	damaging	0.15	damaging	3.00	22.20	deleterious	0.37	0.55	0.3	neutral	0.41	neutral	0.51	disease	0.4	neutral	2	0.92	neutral	0.29	neutral	1	deleterious	0.40	neutral	-0.76	medium_impact	-0.43	medium_impact	2.32	high_impact	0.82	0.9	1.56	7.16	0.54	P	0.66	disease_causing	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6213	6213	C	T	MI.2551	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	310	104	L	F	Ctc/Ttc	1.98	1	0	possibly_damaging	0.85	deleterious	0.03	neutral	2.44	neutral	-2.83	deleterious	-2.66	medium_impact	2.4	0.52	damaging	0.11	damaging	3.83	23.40	deleterious	0.34	0.55	0.59	disease	0.46	neutral	0.51	disease	0.56	disease	1	0.98	deleterious	0.09	neutral	4	deleterious	0.69	deleterious	-1.47	low_impact	-0.65	medium_impact	1.12	medium_impact	0.72	0.9	1.56	7.16	0.49	P	0.87	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6213	6213	C	A	MI.2552	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	310	104	L	I	Ctc/Atc	1.98	1	0	possibly_damaging	0.82	deleterious	0.03	neutral	2.55	neutral	-1.4	neutral	-1.47	high_impact	3.62	0.55	damaging	0.14	damaging	3.83	23.40	deleterious	0.29	0.55	0.38	neutral	0.51	disease	0.48	neutral	0.46	neutral	1	0.98	deleterious	0.11	neutral	5	deleterious	0.53	deleterious	-1.38	low_impact	-0.65	medium_impact	2.24	high_impact	0.77	0.9	1.56	7.16	0.51	P	0.54	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6214	6214	T	G	MI.2553	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	311	104	L	R	cTc/cGc	1.52	1	0	possibly_damaging	0.74	deleterious	0	neutral	2.39	deleterious	-4.53	deleterious	-4.59	high_impact	5.14	0.53	damaging	0.11	damaging	3.97	23.60	deleterious	0.12	0.55	0.73	disease	0.79	disease	0.72	disease	0.74	disease	5	1	deleterious	0.13	neutral	5	deleterious	0.82	deleterious	-1.18	low_impact	-1.48	low_impact	3.65	high_impact	0.53	0.9	1.56	7.16	0.62	P	0.90	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6214	6214	T	A	MI.2554	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	311	104	L	H	cTc/cAc	1.52	1	0	benign	0.08	deleterious	0	neutral	2.39	deleterious	-5.06	deleterious	-5.24	high_impact	5.14	0.59	damaging	0.1	damaging	2.33	18.38	deleterious	0.12	0.55	0.79	disease	0.73	disease	0.69	disease	0.72	disease	4	1	deleterious	0.46	neutral	2	deleterious	0.31	neutral	0.24	medium_impact	-1.48	low_impact	3.65	high_impact	0.54	0.9	1.56	7.16	0.56	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6214	6214	T	C	MI.2555	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	311	104	L	P	cTc/cCc	1.52	1	0	probably_damaging	0.98	deleterious	0	neutral	2.39	deleterious	-5.1	deleterious	-5.39	high_impact	5.14	0.47	damaging	0.12	damaging	3.83	23.40	deleterious	0.15	0.55	0.79	disease	0.7	disease	0.71	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.35	low_impact	-1.48	low_impact	3.65	high_impact	0.74	0.9	1.56	7.16	0.59	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6216	6216	T	G	MI.2556	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	313	105	L	V	Tta/Gta	-20	0	0.02	probably_damaging	0.99	neutral	0.05	neutral	2.61	neutral	-1.5	neutral	-2.11	medium_impact	3.41	0.56	damaging	0.13	damaging	3.31	22.90	deleterious	0.39	0.55	0.34	neutral	0.47	neutral	0.47	neutral	0.43	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.69	deleterious	-2.64	low_impact	-0.52	medium_impact	2.05	high_impact	0.65	0.9	2.34	6.67	0.35	N	0.66	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6216	6216	T	A	MI.2557	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	313	105	L	M	Tta/Ata	-20	0	0.02	probably_damaging	1	deleterious	0	neutral	2.6	neutral	-1.67	neutral	-1.52	high_impact	3.52	0.63	neutral	0.16	damaging	3.49	23.10	deleterious	0.33	0.55	0.52	disease	0.51	disease	0.47	neutral	0.46	neutral	1	1	deleterious	0	neutral	6	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	2.15	high_impact	0.63	0.9	2.34	6.67	0.36	N	0.59	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6217	6217	T	C	MI.2558	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	314	105	L	S	tTa/tCa	1.52	0.76	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-3	deleterious	-4.66	high_impact	4.1	0.64	neutral	0.13	damaging	3.65	23.20	deleterious	0.21	0.55	0.48	neutral	0.67	disease	0.56	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.69	high_impact	0.73	0.9	2.34	6.67	0.31	N	0.73	disease_causing	0.93	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6217	6217	T	G	MI.2559	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	314	105	L	W	tTa/tGa	1.52	0.76	0	probably_damaging	1	deleterious	0	neutral	2.57	neutral	-2.18	deleterious	-4.73	high_impact	4.45	0.6	neutral	0.13	damaging	3.68	23.30	deleterious	0.12	0.55	0.6	disease	0.66	disease	0.6	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.52	0.9	2.34	6.67	0.4	N	0.92	disease_causing	0.95	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8645	8645	A	T	MI.256	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	119	40	N	I	aAc/aTc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	4.32	neutral	-2.68	deleterious	-7.58	medium_impact	3.48	0.82	neutral	0.57	neutral	4.29	24.00	deleterious	0.32	0.65	0.88	disease	0.86	disease	0.65	disease	0.78	disease	6	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	1.89	medium_impact	0.42	0.9	48.67	8.5	0.55	P	1.00	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6218	6218	A	C	MI.2560	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	315	105	L	F	ttA/ttC	7.53	0.99	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-0.91	deleterious	-3.07	medium_impact	3.31	0.54	damaging	0.09	damaging	3.34	22.90	deleterious	0.3	0.55	0.23	neutral	0.59	disease	0.49	neutral	0.49	neutral	0	1	deleterious	0	neutral	5	deleterious	0.70	deleterious	-3.58	low_impact	-1.48	low_impact	1.96	medium_impact	0.66	0.9	2.34	6.67	0.51	P	0.87	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6218	6218	A	T	MI.2561	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	315	105	L	F	ttA/ttT	7.53	0.99	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-0.91	deleterious	-3.07	medium_impact	3.31	0.54	damaging	0.09	damaging	3.47	23.00	deleterious	0.3	0.55	0.23	neutral	0.59	disease	0.49	neutral	0.49	neutral	0	1	deleterious	0	neutral	5	deleterious	0.70	deleterious	-3.58	low_impact	-1.48	low_impact	1.96	medium_impact	0.66	0.9	2.34	6.67	0.52	P	0.87	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6219	6219	C	T	MI.2562	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	316	106	P	S	Cct/Tct	-20	0	0	benign	0.02	deleterious	0	neutral	2.74	neutral	-1.29	deleterious	-6.14	high_impact	4.38	0.61	neutral	0.49	neutral	3.79	23.40	deleterious	0.3	0.55	0.56	disease	0.66	disease	0.57	disease	0.64	disease	3	1	deleterious	0.49	deleterious	2	deleterious	0.20	neutral	0.83	medium_impact	-1.48	low_impact	2.95	high_impact	0.32	0.9	2.73	7.05	0.47	N	0.85	polymorphism	0.9	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6219	6219	C	A	MI.2563	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	316	106	P	T	Cct/Act	-20	0	0	benign	0.26	deleterious	0	neutral	2.77	neutral	-0.66	deleterious	-6.1	high_impact	4.1	0.6	damaging	0.37	neutral	3.62	23.20	deleterious	0.22	0.55	0.5	disease	0.64	disease	0.58	disease	0.64	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.34	neutral	-0.33	medium_impact	-1.48	low_impact	2.69	high_impact	0.48	0.9	2.73	7.05	0.4	N	0.80	polymorphism	0.9	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6219	6219	C	G	MI.2564	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	316	106	P	A	Cct/Gct	-20	0	0	benign	0.04	deleterious	0	neutral	2.84	neutral	0.37	deleterious	-6.1	high_impact	4.04	0.64	neutral	0.48	neutral	2.96	22.10	deleterious	0.2	0.55	0.45	neutral	0.51	disease	0.59	disease	0.62	disease	2	1	deleterious	0.48	deleterious	2	deleterious	0.22	neutral	0.54	medium_impact	-1.48	low_impact	2.63	high_impact	0.51	0.9	2.73	7.05	0.46	N	0.76	polymorphism	0.93	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6220	6220	C	T	MI.2565	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	317	106	P	L	cCt/cTt	7.3	1	0	possibly_damaging	0.6	deleterious	0.02	neutral	2.94	neutral	1.19	deleterious	-7.56	medium_impact	2.54	0.49	damaging	0.41	neutral	4.16	23.80	deleterious	0.2	0.55	0.19	neutral	0.77	disease	0.55	disease	0.62	disease	2	0.98	deleterious	0.21	neutral	4	deleterious	0.53	deleterious	-0.92	medium_impact	-0.75	medium_impact	1.25	medium_impact	0.75	0.9	2.73	7.05	0.5	P	0.87	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6220	6220	C	G	MI.2566	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	317	106	P	R	cCt/cGt	7.3	1	0	possibly_damaging	0.82	deleterious	0	neutral	2.72	neutral	-2.16	deleterious	-6.94	high_impact	5.08	0.59	damaging	0.35	neutral	3.45	23.00	deleterious	0.17	0.55	0.68	disease	0.81	disease	0.73	disease	0.75	disease	5	1	deleterious	0.09	neutral	5	deleterious	0.70	deleterious	-1.38	low_impact	-1.48	low_impact	3.59	high_impact	0.50	0.9	2.73	7.05	0.68	P	0.90	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6220	6220	C	A	MI.2567	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	317	106	P	H	cCt/cAt	7.3	1	0	possibly_damaging	0.89	deleterious	0	neutral	2.73	neutral	-2.05	deleterious	-6.95	high_impact	5.08	0.59	damaging	0.34	neutral	3.94	23.50	deleterious	0.21	0.55	0.75	disease	0.78	disease	0.69	disease	0.71	disease	4	1	deleterious	0.06	neutral	5	deleterious	0.73	deleterious	-1.61	low_impact	-1.48	low_impact	3.59	high_impact	0.36	0.9	2.73	7.05	0.69	P	0.81	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6222	6222	C	G	MI.2568	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	319	107	P	A	Ccc/Gcc	-9.36	0	0	probably_damaging	1	deleterious	0.04	neutral	2.91	neutral	1.19	deleterious	-6.42	high_impact	3.72	0.66	neutral	0.06	damaging	3.02	22.30	deleterious	0.24	0.55	0.23	neutral	0.5	neutral	0.41	neutral	0.43	neutral	1	1	deleterious	0.02	neutral	6	deleterious	0.68	deleterious	-3.58	low_impact	-0.58	medium_impact	2.34	high_impact	0.69	0.9	2.92	6.77	0.35	N	0.76	polymorphism	0.93	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6222	6222	C	T	MI.2569	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	319	107	P	S	Ccc/Tcc	-9.36	0	0	probably_damaging	1	deleterious	0.02	neutral	2.79	neutral	-0.35	deleterious	-6.41	medium_impact	3.37	0.64	neutral	0.03	damaging	3.82	23.40	deleterious	0.34	0.55	0.41	neutral	0.7	disease	0.5	neutral	0.49	neutral	0	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-0.75	medium_impact	2.01	high_impact	0.47	0.9	2.92	6.77	0.29	N	0.85	polymorphism	0.9	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8645	8645	A	C	MI.257	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	119	40	N	T	aAc/aCc	5.68	1	0	probably_damaging	0.99	neutral	0.09	neutral	4.39	neutral	-1.01	deleterious	-5.06	low_impact	1.47	0.87	neutral	0.55	neutral	3.70	23.30	deleterious	0.72	0.75	0.68	disease	0.75	disease	0.43	neutral	0.55	disease	1	1	deleterious	0.05	neutral	-2	neutral	0.79	deleterious	-2.65	low_impact	-0.28	medium_impact	0.16	medium_impact	0.66	0.9	48.67	8.5	0.51	N	0.96	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6222	6222	C	A	MI.2570	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	319	107	P	T	Ccc/Acc	-9.36	0	0	probably_damaging	1	neutral	0.07	neutral	2.8	neutral	-0.1	deleterious	-6.42	high_impact	4.56	0.66	neutral	0.04	damaging	3.61	23.20	deleterious	0.25	0.55	0.32	neutral	0.67	disease	0.58	disease	0.58	disease	2	1	deleterious	0.04	neutral	2	deleterious	0.70	deleterious	-3.58	low_impact	-0.43	medium_impact	3.11	high_impact	0.68	0.9	2.92	6.77	0.4	N	0.80	polymorphism	0.9	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6223	6223	C	A	MI.2571	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	320	107	P	H	cCc/cAc	4.52	0.99	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.55	deleterious	-7.22	high_impact	4.3	0.65	neutral	0.02	damaging	3.93	23.50	deleterious	0.21	0.55	0.63	disease	0.81	disease	0.67	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.87	high_impact	0.52	0.9	2.92	6.77	0.47	N	0.81	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6223	6223	C	G	MI.2572	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	320	107	P	R	cCc/cGc	4.52	0.99	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-1.98	deleterious	-7.23	high_impact	5.11	0.62	neutral	0.03	damaging	3.51	23.10	deleterious	0.18	0.55	0.55	disease	0.83	disease	0.72	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.65	0.9	2.92	6.77	0.66	P	0.90	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6223	6223	C	T	MI.2573	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	320	107	P	L	cCc/cTc	4.52	0.99	0	probably_damaging	1	deleterious	0	neutral	2.97	neutral	1.56	deleterious	-8.02	high_impact	3.87	0.66	neutral	0.02	damaging	4.30	24.00	deleterious	0.32	0.55	0.24	neutral	0.82	disease	0.55	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.70	deleterious	-3.58	low_impact	-1.48	low_impact	2.47	high_impact	0.86	0.9	2.92	6.77	0.45	N	0.87	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6225	6225	T	C	MI.2574	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	322	108	S	P	Tct/Cct	-11.44	0	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-3.78	deleterious	-3.51	high_impact	3.96	0.45	damaging	0.06	damaging	3.86	23.50	deleterious	0.21	0.55	0.73	disease	0.81	disease	0.71	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.56	0.9	1.36	6.84	0.33	N	0.91	polymorphism	0.98	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6225	6225	T	A	MI.2575	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	322	108	S	T	Tct/Act	-11.44	0	0	probably_damaging	0.97	deleterious	0	neutral	2.68	neutral	-1.63	neutral	-2.07	high_impact	4.58	0.49	damaging	0.06	damaging	3.66	23.20	deleterious	0.28	0.55	0.19	neutral	0.51	disease	0.53	disease	0.53	disease	1	1	deleterious	0.02	neutral	6	deleterious	0.66	deleterious	-2.18	low_impact	-1.48	low_impact	3.13	high_impact	0.66	0.9	1.36	6.84	0.44	N	0.43	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6225	6225	T	G	MI.2576	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	322	108	S	A	Tct/Gct	-11.44	0	0	probably_damaging	0.99	neutral	0.29	neutral	3.05	neutral	1.29	neutral	-1.36	low_impact	1.08	0.48	damaging	0.21	damaging	2.15	17.18	deleterious	0.32	0.55	0.21	neutral	0.18	neutral	0.32	neutral	0.25	neutral	5	0.99	deleterious	0.15	neutral	-2	neutral	0.63	deleterious	-2.64	low_impact	-0.02	medium_impact	-0.1	medium_impact	0.58	0.9	1.36	6.84	0.44	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6226	6226	C	G	MI.2577	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	323	108	S	C	tCt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-4.35	deleterious	-3.33	high_impact	4.93	0.49	damaging	0.04	damaging	3.48	23.10	deleterious	0.2	0.55	0.8	disease	0.7	disease	0.59	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.58	0.9	1.36	6.84	0.66	P	0.85	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6226	6226	C	T	MI.2578	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	323	108	S	F	tCt/tTt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-4.26	deleterious	-4.31	high_impact	4.24	0.49	damaging	0.04	damaging	4.08	23.70	deleterious	0.15	0.55	0.86	disease	0.78	disease	0.63	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.82	high_impact	0.33	0.9	1.36	6.84	0.47	N	0.98	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6226	6226	C	A	MI.2579	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	323	108	S	Y	tCt/tAt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-4.54	deleterious	-4.31	high_impact	4.93	0.5	damaging	0.06	damaging	3.87	23.50	deleterious	0.17	0.55	0.88	disease	0.75	disease	0.63	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.55	0.9	1.36	6.84	0.67	P	0.92	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8646	8646	C	A	MI.258	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	120	40	N	K	aaC/aaA	5.68	1	0	probably_damaging	0.99	neutral	0.07	neutral	4.34	neutral	-0.62	deleterious	-5.12	medium_impact	2.79	0.79	neutral	0.4	neutral	4.26	23.90	deleterious	0.76	0.8	0.63	disease	0.81	disease	0.69	disease	0.71	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.83	deleterious	-2.65	low_impact	-0.34	medium_impact	1.29	medium_impact	0.73	0.9	48.67	8.5	0.51	P	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6228	6228	C	A	MI.2580	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	325	109	L	I	Ctc/Atc	-6.58	0	0.01	benign	0.13	neutral	0.05	neutral	2.7	neutral	-0.94	neutral	-0.85	medium_impact	2	0.71	neutral	0.73	neutral	0.93	10.26	neutral	0.32	0.55	0.2	neutral	0.37	neutral	0.29	neutral	0.44	neutral	1	0.94	neutral	0.46	neutral	-3	neutral	0.16	neutral	0.02	medium_impact	-0.52	medium_impact	0.75	medium_impact	0.54	0.9	8.38	33.89	0.56	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6228	6228	C	G	MI.2581	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	325	109	L	V	Ctc/Gtc	-6.58	0	0.01	benign	0.13	neutral	0.06	neutral	2.76	neutral	-0.36	neutral	-1.58	high_impact	3.52	0.68	neutral	0.7	neutral	1.36	12.60	neutral	0.37	0.55	0.31	neutral	0.41	neutral	0.44	neutral	0.45	neutral	1	0.93	neutral	0.47	neutral	-2	neutral	0.17	neutral	0.02	medium_impact	-0.47	medium_impact	2.15	high_impact	0.58	0.9	8.38	33.89	0.51	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6228	6228	C	T	MI.2582	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	325	109	L	F	Ctc/Ttc	-6.58	0	0.01	benign	0	neutral	0.67	neutral	2.64	neutral	-1.99	neutral	-1.38	low_impact	1.32	0.77	neutral	0.99	neutral	0.29	5.62	deleterious	0.36	0.55	0.27	neutral	0.16	neutral	0.26	neutral	0.23	neutral	5	0.32	neutral	0.84	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.36	medium_impact	0.12	medium_impact	0.61	0.9	8.38	33.89	0.42	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6229	6229	T	C	MI.2583	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	326	109	L	P	cTc/cCc	3.14	0.99	0	possibly_damaging	0.79	deleterious	0	neutral	2.61	neutral	-2.99	deleterious	-4.85	high_impact	4.29	0.5	damaging	0.43	neutral	2.00	16.20	deleterious	0.16	0.55	0.7	disease	0.76	disease	0.66	disease	0.69	disease	4	1	deleterious	0.11	neutral	5	deleterious	0.69	deleterious	-1.3	low_impact	-1.48	low_impact	2.86	high_impact	0.55	0.9	8.38	33.89	0.52	P	0.39	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6229	6229	T	G	MI.2584	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	326	109	L	R	cTc/cGc	3.14	0.99	0	possibly_damaging	0.65	deleterious	0	neutral	2.61	deleterious	-3.3	deleterious	-4.18	high_impact	4.84	0.56	damaging	0.5	neutral	2.23	17.70	deleterious	0.15	0.55	0.61	disease	0.81	disease	0.66	disease	0.71	disease	4	1	deleterious	0.18	neutral	5	deleterious	0.59	deleterious	-1.01	low_impact	-1.48	low_impact	3.37	high_impact	0.56	0.9	8.38	33.89	0.65	P	0.25	polymorphism	0.83	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6229	6229	T	A	MI.2585	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	326	109	L	H	cTc/cAc	3.14	0.99	0	possibly_damaging	0.79	deleterious	0	neutral	2.6	deleterious	-3.91	deleterious	-4.4	high_impact	4.84	0.64	neutral	0.52	neutral	2.22	17.66	deleterious	0.2	0.55	0.58	disease	0.69	disease	0.55	disease	0.64	disease	3	1	deleterious	0.11	neutral	5	deleterious	0.62	deleterious	-1.3	low_impact	-1.48	low_impact	3.37	high_impact	0.50	0.9	8.38	33.89	0.66	P	0.17	polymorphism	0.9	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6231	6231	C	A	MI.2586	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	328	110	L	M	Cta/Ata	-3.34	0	0	probably_damaging	1	neutral	0.1	neutral	2.58	neutral	-2.66	neutral	-0.14	neutral_impact	0.76	0.7	neutral	0.23	damaging	2.24	17.77	deleterious	0.26	0.55	0.34	neutral	0.12	neutral	0.19	neutral	0.3	neutral	4	1	deleterious	0.05	neutral	-2	neutral	0.66	deleterious	-3.58	low_impact	-0.34	medium_impact	-0.4	medium_impact	0.55	0.9	3.12	7.51	0.49	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6231	6231	C	G	MI.2587	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	328	110	L	V	Cta/Gta	-3.34	0	0	probably_damaging	0.97	neutral	0.07	neutral	2.84	neutral	0.17	neutral	-0.29	low_impact	1.4	0.66	neutral	0.12	damaging	0.58	7.99	deleterious	0.29	0.55	0.23	neutral	0.19	neutral	0.21	neutral	0.38	neutral	2	0.99	deleterious	0.05	neutral	-2	neutral	0.62	deleterious	-2.18	low_impact	-0.43	medium_impact	0.19	medium_impact	0.37	0.9	3.12	7.51	0.42	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6232	6232	T	A	MI.2588	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	329	110	L	Q	cTa/cAa	1.75	0.9	0	probably_damaging	1	deleterious	0.01	neutral	2.56	deleterious	-3.93	neutral	-2.32	high_impact	3.63	0.65	neutral	0.09	damaging	2.84	21.60	deleterious	0.16	0.55	0.69	disease	0.46	neutral	0.44	neutral	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-0.92	medium_impact	2.25	high_impact	0.43	0.9	3.12	7.51	0.37	N	0.82	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6232	6232	T	G	MI.2589	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	329	110	L	R	cTa/cGa	1.75	0.9	0	probably_damaging	1	deleterious	0.01	neutral	2.56	deleterious	-3.75	neutral	-2.49	high_impact	3.63	0.6	damaging	0.08	damaging	2.98	22.20	deleterious	0.14	0.55	0.67	disease	0.69	disease	0.59	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-0.92	medium_impact	2.25	high_impact	0.46	0.9	3.12	7.51	0.29	N	0.90	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8646	8646	C	G	MI.259	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	120	40	N	K	aaC/aaG	5.68	1	0	probably_damaging	0.99	neutral	0.07	neutral	4.34	neutral	-0.62	deleterious	-5.12	medium_impact	2.79	0.79	neutral	0.4	neutral	3.85	23.40	deleterious	0.76	0.8	0.63	disease	0.81	disease	0.69	disease	0.71	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.83	deleterious	-2.65	low_impact	-0.34	medium_impact	1.29	medium_impact	0.73	0.9	48.67	8.5	0.49	P	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6232	6232	T	C	MI.2590	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	329	110	L	P	cTa/cCa	1.75	0.9	0	probably_damaging	1	deleterious	0.01	neutral	2.55	deleterious	-4.32	deleterious	-2.85	high_impact	3.63	0.59	damaging	0.07	damaging	2.62	20.30	deleterious	0.14	0.55	0.74	disease	0.73	disease	0.58	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-0.92	medium_impact	2.25	high_impact	0.50	0.9	3.12	7.51	0.3	N	0.83	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6234	6234	C	A	MI.2591	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	331	111	L	I	Ctc/Atc	-20	0	0	possibly_damaging	0.63	deleterious	0	neutral	2.49	neutral	-1.29	neutral	-1.5	medium_impact	3.08	0.49	damaging	0.13	damaging	4.01	23.60	deleterious	0.26	0.55	0.43	neutral	0.55	disease	0.41	neutral	0.47	neutral	1	1	deleterious	0.19	neutral	4	deleterious	0.42	neutral	-0.97	medium_impact	-1.48	low_impact	1.75	medium_impact	0.59	0.9	2.73	6.77	0.39	N	0.54	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6234	6234	C	G	MI.2592	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	331	111	L	V	Ctc/Gtc	-20	0	0	benign	0.28	deleterious	0	neutral	2.59	neutral	-1.03	neutral	-2.26	high_impact	3.91	0.46	damaging	0.12	damaging	3.33	22.90	deleterious	0.31	0.55	0.4	neutral	0.46	neutral	0.52	disease	0.46	neutral	1	1	deleterious	0.36	neutral	2	deleterious	0.27	neutral	-0.37	medium_impact	-1.48	low_impact	2.51	high_impact	0.47	0.9	2.73	6.77	0.41	N	0.66	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6234	6234	C	T	MI.2593	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	331	111	L	F	Ctc/Ttc	-20	0	0	probably_damaging	0.91	neutral	0.07	neutral	2.46	neutral	-2.6	deleterious	-2.78	low_impact	1.86	0.42	damaging	0.09	damaging	3.87	23.50	deleterious	0.26	0.55	0.4	neutral	0.39	neutral	0.32	neutral	0.42	neutral	2	0.98	neutral	0.08	neutral	-2	neutral	0.68	deleterious	-1.7	low_impact	-0.43	medium_impact	0.62	medium_impact	0.40	0.9	2.73	6.77	0.36	N	0.87	polymorphism	0.98	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6235	6235	T	A	MI.2594	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	332	111	L	H	cTc/cAc	0.13	0.01	0	probably_damaging	0.95	deleterious	0	neutral	2.37	deleterious	-4.7	deleterious	-5.31	high_impact	4.66	0.53	damaging	0.09	damaging	4.22	23.90	deleterious	0.15	0.55	0.39	neutral	0.74	disease	0.61	disease	0.65	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.72	deleterious	-1.96	low_impact	-1.48	low_impact	3.2	high_impact	0.41	0.9	2.73	6.77	0.41	N	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6235	6235	T	C	MI.2595	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	332	111	L	P	cTc/cCc	0.13	0.01	0	benign	0.06	deleterious	0	neutral	2.37	deleterious	-4.86	deleterious	-5.42	high_impact	4.66	0.42	damaging	0.12	damaging	3.87	23.50	deleterious	0.14	0.55	0.8	disease	0.77	disease	0.65	disease	0.73	disease	5	1	deleterious	0.47	deleterious	2	deleterious	0.31	neutral	0.37	medium_impact	-1.48	low_impact	3.2	high_impact	0.37	0.9	2.73	6.77	0.5	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6235	6235	T	G	MI.2596	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	332	111	L	R	cTc/cGc	0.13	0.01	0	possibly_damaging	0.9	deleterious	0	neutral	2.38	deleterious	-4.28	deleterious	-4.61	high_impact	5.01	0.51	damaging	0.1	damaging	4.10	23.70	deleterious	0.11	0.55	0.74	disease	0.83	disease	0.66	disease	0.72	disease	4	1	deleterious	0.05	neutral	5	deleterious	0.81	deleterious	-1.65	low_impact	-1.48	low_impact	3.53	high_impact	0.38	0.9	2.73	6.77	0.62	P	0.90	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6237	6237	C	G	MI.2597	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	334	112	L	V	Ctg/Gtg	-20	0	0	probably_damaging	0.98	neutral	0.1	neutral	2.82	neutral	-0.7	neutral	-2.33	medium_impact	3.04	0.44	damaging	0.39	neutral	3.36	22.90	deleterious	0.34	0.55	0.22	neutral	0.4	neutral	0.48	neutral	0.39	neutral	2	0.99	deleterious	0.06	neutral	1	deleterious	0.67	deleterious	-2.35	low_impact	-0.34	medium_impact	1.71	medium_impact	0.68	0.9	2.14	6.78	0.51	N	0.66	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6237	6237	C	A	MI.2598	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	334	112	L	M	Ctg/Atg	-20	0	0	probably_damaging	1	deleterious	0.03	neutral	2.68	neutral	-1.28	neutral	-1.51	medium_impact	2.42	0.37	damaging	0.56	neutral	3.69	23.30	deleterious	0.25	0.55	0.45	neutral	0.41	neutral	0.31	neutral	0.42	neutral	2	1	deleterious	0.02	neutral	5	deleterious	0.70	deleterious	-3.58	low_impact	-0.65	medium_impact	1.14	medium_impact	0.58	0.9	2.14	6.78	0.62	P	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6238	6238	T	C	MI.2599	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	335	112	L	P	cTg/cCg	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-4.44	deleterious	-5.58	high_impact	4.39	0.4	damaging	0.35	neutral	3.82	23.40	deleterious	0.15	0.55	0.88	disease	0.71	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.55	0.9	2.14	6.78	0.63	P	0.83	disease_causing	0.75	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8537	8537	A	C	MI.26	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	11	4	N	T	aAt/aCt	5.91	1	0.01	benign	0.07	neutral	0.13	neutral	4.47	neutral	-0.91	deleterious	-3.74	medium_impact	2.5	0.87	neutral	0.62	neutral	3.28	22.80	deleterious	0.61	0.7	0.71	disease	0.33	neutral	0.34	neutral	0.64	disease	3	0.86	neutral	0.53	deleterious	-3	neutral	0.22	neutral	0.31	medium_impact	-0.18	medium_impact	1.05	medium_impact	0.38	0.9	41.59	7.51	0.73	P	0.75	disease_causing	0.96	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8647	8647	C	T	MI.260	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	121	41	R	W	Cga/Tga	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	4.16	deleterious	-5.77	deleterious	-7.18	high_impact	4	0.59	damaging	0.28	neutral	5.03	25.20	deleterious	0.31	0.65	0.96	disease	0.89	disease	0.79	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.33	high_impact	0.77	0.9	44.69	8.36	0.37	N	1.00	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6238	6238	T	A	MI.2600	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	335	112	L	Q	cTg/cAg	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-4.01	deleterious	-4.76	high_impact	5.08	0.49	damaging	0.39	neutral	4.10	23.70	deleterious	0.14	0.55	0.85	disease	0.69	disease	0.58	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.61	0.9	2.14	6.78	0.63	P	0.82	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6238	6238	T	G	MI.2601	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	335	112	L	R	cTg/cGg	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.84	deleterious	-4.78	high_impact	5.08	0.49	damaging	0.31	neutral	4.10	23.70	deleterious	0.12	0.55	0.84	disease	0.78	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.50	0.9	2.14	6.78	0.66	P	0.90	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6240	6240	C	A	MI.2602	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	337	113	L	I	Ctc/Atc	-16.07	0	0	benign	0	neutral	0.23	neutral	2.65	neutral	-0.95	neutral	-0.32	neutral_impact	0.8	0.64	neutral	0.63	neutral	0.65	8.49	deleterious	0.37	0.55	0.34	neutral	0.18	neutral	0.22	neutral	0.28	neutral	4	0.77	neutral	0.62	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	-0.1	medium_impact	-0.36	medium_impact	0.68	0.9	12.67	32.83	0.56	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6240	6240	C	T	MI.2603	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	337	113	L	F	Ctc/Ttc	-16.07	0	0	benign	0.18	deleterious	0.02	neutral	2.53	neutral	-2.39	neutral	-1.93	medium_impact	2.68	0.58	damaging	0.44	neutral	2.02	16.35	deleterious	0.36	0.55	0.54	disease	0.47	neutral	0.31	neutral	0.52	disease	0	0.98	neutral	0.42	neutral	1	deleterious	0.48	deleterious	-0.14	medium_impact	-0.75	medium_impact	1.38	medium_impact	0.60	0.9	12.67	32.83	0.45	N	0.82	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6240	6240	C	G	MI.2604	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	337	113	L	V	Ctc/Gtc	-16.07	0	0	benign	0.01	deleterious	0.04	neutral	2.67	neutral	-0.81	neutral	-0.88	low_impact	1.87	0.6	damaging	0.48	neutral	0.24	5.06	deleterious	0.37	0.55	0.2	neutral	0.24	neutral	0.26	neutral	0.43	neutral	1	0.96	neutral	0.52	deleterious	-2	neutral	0.11	neutral	1.12	medium_impact	-0.58	medium_impact	0.63	medium_impact	0.56	0.9	12.67	32.83	0.56	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6241	6241	T	C	MI.2605	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	338	113	L	P	cTc/cCc	-1.03	0	0	possibly_damaging	0.81	deleterious	0	neutral	2.49	deleterious	-4.05	deleterious	-4.44	high_impact	4.59	0.57	damaging	0.41	neutral	2.19	17.43	deleterious	0.14	0.55	0.73	disease	0.8	disease	0.65	disease	0.7	disease	4	1	deleterious	0.1	neutral	5	deleterious	0.77	deleterious	-1.35	low_impact	-1.48	low_impact	3.14	high_impact	0.54	0.9	12.67	32.83	0.48	N	0.81	disease_causing	0.54	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6241	6241	T	A	MI.2606	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	338	113	L	H	cTc/cAc	-1.03	0	0	possibly_damaging	0.74	deleterious	0	neutral	2.48	deleterious	-4.34	deleterious	-4.36	high_impact	4.59	0.61	neutral	0.39	neutral	3.67	23.20	deleterious	0.16	0.55	0.3	neutral	0.69	disease	0.59	disease	0.66	disease	3	1	deleterious	0.13	neutral	5	deleterious	0.63	deleterious	-1.18	low_impact	-1.48	low_impact	3.14	high_impact	0.59	0.9	12.67	32.83	0.5	N	0.69	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6241	6241	T	G	MI.2607	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	338	113	L	R	cTc/cGc	-1.03	0	0	possibly_damaging	0.49	deleterious	0	neutral	2.48	deleterious	-4.11	deleterious	-4.01	high_impact	4.59	0.57	damaging	0.34	neutral	2.30	18.13	deleterious	0.13	0.55	0.63	disease	0.81	disease	0.64	disease	0.7	disease	4	1	deleterious	0.26	neutral	5	deleterious	0.64	deleterious	-0.74	medium_impact	-1.48	low_impact	3.14	high_impact	0.66	0.9	12.67	32.83	0.46	N	0.91	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6243	6243	G	T	MI.2608	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	340	114	A	S	Gca/Tca	-2.65	0	0	possibly_damaging	0.5	neutral	0.48	neutral	2.73	neutral	-0.97	neutral	0.03	neutral_impact	-0.36	0.67	neutral	0.62	neutral	-0.59	0.13	neutral	0.39	0.55	0.32	neutral	0.11	neutral	0.21	neutral	0.3	neutral	4	0.52	neutral	0.49	deleterious	-3	neutral	0.27	neutral	-0.76	medium_impact	0.17	medium_impact	-1.43	low_impact	0.81	0.9	7.02	9.53	0.4	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6243	6243	G	A	MI.2609	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	340	114	A	T	Gca/Aca	-2.65	0	0	possibly_damaging	0.7	neutral	0.35	neutral	2.72	neutral	-1.22	neutral	-0.42	low_impact	1	0.71	neutral	0.68	neutral	0.55	7.77	deleterious	0.34	0.55	0.29	neutral	0.15	neutral	0.23	neutral	0.3	neutral	4	0.74	neutral	0.33	neutral	-3	neutral	0.52	deleterious	-1.1	low_impact	0.04	medium_impact	-0.18	medium_impact	0.70	0.9	7.02	9.53	0.46	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8647	8647	C	G	MI.261	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	121	41	R	G	Cga/Gga	-2.42	0	0	probably_damaging	0.99	deleterious	0.01	neutral	4.32	neutral	-0.57	deleterious	-6.32	medium_impact	3.03	0.6	damaging	0.45	neutral	4.06	23.70	deleterious	0.24	0.65	0.52	disease	0.78	disease	0.77	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.65	low_impact	-0.84	medium_impact	1.5	medium_impact	0.43	0.9	44.69	8.36	0.37	N	1.00	disease_causing	1	0.10	rs1064597	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6243	6243	G	C	MI.2610	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	340	114	A	P	Gca/Cca	-2.65	0	0	probably_damaging	0.92	neutral	0.06	neutral	2.66	deleterious	-3.52	neutral	-1.98	medium_impact	3.34	0.59	damaging	0.32	neutral	3.59	23.20	deleterious	0.14	0.55	0.72	disease	0.68	disease	0.5	neutral	0.48	neutral	0	0.98	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-1.76	low_impact	-0.47	medium_impact	1.99	medium_impact	0.73	0.9	7.02	9.53	0.36	N	0.67	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6244	6244	C	A	MI.2611	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	341	114	A	E	gCa/gAa	3.6	1	0	possibly_damaging	0.89	neutral	0.12	neutral	2.66	deleterious	-3.23	neutral	-1.73	medium_impact	3.34	0.61	neutral	0.4	neutral	4.26	23.90	deleterious	0.15	0.55	0.55	disease	0.54	disease	0.49	neutral	0.5	neutral	0	0.96	neutral	0.12	neutral	0	NA	0.71	deleterious	-1.61	low_impact	-0.29	medium_impact	1.99	medium_impact	0.67	0.9	7.02	9.53	0.61	P	0.73	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6244	6244	C	T	MI.2612	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	341	114	A	V	gCa/gTa	3.6	1	0	possibly_damaging	0.73	neutral	0.33	neutral	2.91	neutral	0.74	neutral	-0.61	neutral_impact	0.64	0.67	neutral	0.61	neutral	1.50	13.34	neutral	0.32	0.55	0.37	neutral	0.24	neutral	0.24	neutral	0.44	neutral	1	0.77	neutral	0.3	neutral	-3	neutral	0.58	deleterious	-1.16	low_impact	0.02	medium_impact	-0.51	medium_impact	0.70	0.9	7.02	9.53	0.58	P	0.60	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6244	6244	C	G	MI.2613	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	341	114	A	G	gCa/gGa	3.6	1	0	benign	0	neutral	0.19	neutral	2.7	neutral	-1.52	neutral	-1.76	low_impact	0.88	0.64	neutral	0.56	neutral	0.69	8.76	deleterious	0.22	0.55	0.44	neutral	0.22	neutral	0.33	neutral	0.4	neutral	2	0.81	neutral	0.6	deleterious	-6	neutral	0.15	neutral	2.07	high_impact	-0.16	medium_impact	-0.29	medium_impact	0.63	0.9	7.02	9.53	0.61	P	0.54	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6246	6246	T	G	MI.2614	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	343	115	S	A	Tct/Gct	-9.13	0	0	probably_damaging	0.99	neutral	0.05	neutral	2.61	neutral	-2.5	neutral	-2.23	high_impact	3.62	0.64	neutral	0.17	damaging	3.60	23.20	deleterious	0.26	0.55	0.33	neutral	0.42	neutral	0.59	disease	0.43	neutral	1	1	deleterious	0.03	neutral	2	deleterious	0.70	deleterious	-2.64	low_impact	-0.52	medium_impact	2.24	high_impact	0.55	0.9	1.95	6.85	0.38	N	0.35	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6246	6246	T	A	MI.2615	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	343	115	S	T	Tct/Act	-9.13	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.62	neutral	-2.31	neutral	-2.37	high_impact	4.12	0.55	damaging	0.15	damaging	3.69	23.30	deleterious	0.26	0.55	0.41	neutral	0.51	disease	0.6	disease	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.68	deleterious	-2.64	low_impact	-0.92	medium_impact	2.71	high_impact	0.64	0.9	1.95	6.85	0.35	N	0.43	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6246	6246	T	C	MI.2616	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	343	115	S	P	Tct/Cct	-9.13	0	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-2.83	deleterious	-3.9	high_impact	4.36	0.44	damaging	0.19	damaging	3.86	23.50	deleterious	0.2	0.55	0.7	disease	0.76	disease	0.78	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.93	high_impact	0.63	0.9	1.95	6.85	0.58	P	0.91	polymorphism	0.97	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6247	6247	C	A	MI.2617	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	344	115	S	Y	tCt/tAt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.29	deleterious	-4.72	high_impact	5.16	0.56	damaging	0.12	damaging	3.97	23.60	deleterious	0.16	0.55	0.67	disease	0.75	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.59	0.9	1.95	6.85	0.7	P	0.92	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6247	6247	C	T	MI.2618	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	344	115	S	F	tCt/tTt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.13	deleterious	-4.72	high_impact	5.16	0.42	damaging	0.08	damaging	3.98	23.60	deleterious	0.15	0.55	0.53	disease	0.78	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.44	0.9	1.95	6.85	0.71	P	0.98	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6247	6247	C	G	MI.2619	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	344	115	S	C	tCt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-5.39	deleterious	-3.94	high_impact	4.82	0.53	damaging	0.12	damaging	3.42	23.00	deleterious	0.21	0.55	0.65	disease	0.66	disease	0.66	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.56	0.9	1.95	6.85	0.7	P	0.85	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8648	8648	G	C	MI.262	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	122	41	R	P	cGa/cCa	2.9	0.74	0	probably_damaging	1	deleterious	0.02	neutral	4.18	deleterious	-3.32	deleterious	-6.33	medium_impact	2.93	0.47	damaging	0.37	neutral	4.09	23.70	deleterious	0.14	0.65	0.83	disease	0.89	disease	0.83	disease	0.81	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.89	deleterious	-3.6	low_impact	-0.66	medium_impact	1.41	medium_impact	0.27	0.9	44.69	8.36	0.46	N	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6249	6249	G	C	MI.2620	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	346	116	A	P	Gct/Cct	-13.06	0	0	benign	0.33	neutral	0.07	neutral	2.74	neutral	-1.84	neutral	-2.14	medium_impact	2.52	0.52	damaging	0.38	neutral	3.51	23.10	deleterious	0.11	0.55	0.74	disease	0.84	disease	0.58	disease	0.78	disease	6	0.92	neutral	0.37	neutral	-3	neutral	0.44	deleterious	-0.47	medium_impact	-0.43	medium_impact	1.23	medium_impact	0.83	0.9	12.87	68.74	0.35	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6249	6249	G	T	MI.2621	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	346	116	A	S	Gct/Tct	-13.06	0	0	benign	0	neutral	1	neutral	2.77	neutral	-0.63	neutral	1.13	neutral_impact	-1.16	0.7	neutral	0.93	neutral	-0.90	0.03	neutral	0.42	0.55	0.29	neutral	0.07	neutral	0.2	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	1.86	high_impact	-2.17	low_impact	0.83	0.9	12.87	68.74	0.42	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6249	6249	G	A	MI.2622	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	346	116	A	T	Gct/Act	-13.06	0	0	benign	0	neutral	0.09	neutral	2.77	neutral	-0.66	neutral	-0.72	low_impact	0.94	0.71	neutral	0.68	neutral	2.15	17.20	deleterious	0.38	0.55	0.33	neutral	0.35	neutral	0.26	neutral	0.46	neutral	1	0.91	neutral	0.55	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	-0.37	medium_impact	-0.23	medium_impact	0.77	0.9	12.87	68.74	0.5	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6250	6250	C	T	MI.2623	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	347	116	A	V	gCt/gTt	2.44	0.99	0	benign	0.13	neutral	0.13	neutral	2.88	neutral	0.78	neutral	-2.43	medium_impact	1.94	0.69	neutral	0.75	neutral	2.45	19.16	deleterious	0.33	0.55	0.35	neutral	0.54	disease	0.4	neutral	0.46	neutral	1	0.85	neutral	0.5	deleterious	-3	neutral	0.20	neutral	0.02	medium_impact	-0.27	medium_impact	0.69	medium_impact	0.83	0.9	12.87	68.74	0.51	P	0.66	polymorphism	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6250	6250	C	G	MI.2624	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	347	116	A	G	gCt/gGt	2.44	0.99	0	benign	0.13	neutral	0.16	neutral	2.76	neutral	-0.87	neutral	-1.13	neutral_impact	0.39	0.7	neutral	0.71	neutral	0.83	9.63	deleterious	0.28	0.55	0.67	disease	0.43	neutral	0.39	neutral	0.63	disease	3	0.82	neutral	0.52	deleterious	-6	neutral	0.24	neutral	0.02	medium_impact	-0.21	medium_impact	-0.74	medium_impact	0.77	0.9	12.87	68.74	0.49	N	0.24	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6250	6250	C	A	MI.2625	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	347	116	A	D	gCt/gAt	2.44	0.99	0	benign	0.2	deleterious	0.04	neutral	2.72	deleterious	-3.42	neutral	-1.7	medium_impact	2.98	0.57	damaging	0.47	neutral	3.98	23.60	deleterious	0.17	0.55	0.78	disease	0.83	disease	0.57	disease	0.77	disease	5	0.95	neutral	0.42	neutral	1	deleterious	0.35	neutral	-0.19	medium_impact	-0.58	medium_impact	1.65	medium_impact	0.72	0.9	12.87	68.74	0.46	N	0.40	polymorphism	0.93	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6252	6252	A	C	MI.2626	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	349	117	M	L	Ata/Cta	-9.82	0	0	benign	0	neutral	0.66	neutral	3.13	neutral	1.26	neutral	-0.4	neutral_impact	-0.46	0.77	neutral	0.83	neutral	-1.38	0.00	neutral	0.57	0.6	0.27	neutral	0.27	neutral	0.26	neutral	0.44	neutral	1	0.34	neutral	0.83	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.35	medium_impact	-1.52	low_impact	0.58	0.9	15.79	29.72	0.38	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6252	6252	A	T	MI.2627	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	349	117	M	L	Ata/Tta	-9.82	0	0	benign	0	neutral	0.66	neutral	3.13	neutral	1.26	neutral	-0.4	neutral_impact	-0.46	0.77	neutral	0.83	neutral	-1.23	0.01	neutral	0.57	0.6	0.27	neutral	0.27	neutral	0.26	neutral	0.44	neutral	1	0.34	neutral	0.83	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.35	medium_impact	-1.52	low_impact	0.58	0.9	15.79	29.72	0.38	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6252	6252	A	G	MI.2628	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	349	117	M	V	Ata/Gta	-9.82	0	0	benign	0	neutral	0.29	neutral	2.89	neutral	0.54	neutral	-0.93	low_impact	1.5	0.78	neutral	0.84	neutral	-0.62	0.11	neutral	0.59	0.65	0.18	neutral	0.39	neutral	0.38	neutral	0.44	neutral	1	0.71	neutral	0.65	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	-0.02	medium_impact	0.29	medium_impact	0.61	0.9	15.79	29.72	0.41	N	0.02	polymorphism	1	0.02	rs878927119	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6253	6253	T	C	MI.2629	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	350	117	M	T	aTa/aCa	4.06	0.99	0.05	benign	0	neutral	0.37	neutral	2.79	neutral	-0.56	neutral	-2.08	medium_impact	2.12	0.79	neutral	0.98	neutral	-0.64	0.10	neutral	0.5	0.55	0.31	neutral	0.36	neutral	0.49	neutral	0.45	neutral	1	0.63	neutral	0.69	deleterious	-3	neutral	0.13	neutral	2.07	high_impact	0.06	medium_impact	0.86	medium_impact	0.34	0.9	15.79	29.72	0.67	P	0.01	polymorphism	1	0.03	rs200165736	.	.	.	.	.	.	.	14.09	T6253C	Prostate Cancer / enriched in POAG cohort	+	-	Reported	3	N	P	N,P	neutral
chrM	8648	8648	G	A	MI.263	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	122	41	R	Q	cGa/cAa	2.9	0.74	0	probably_damaging	0.99	deleterious	0.02	neutral	4.23	neutral	-1.69	deleterious	-3.62	medium_impact	3.19	0.69	neutral	0.37	neutral	4.31	24.00	deleterious	0.3	0.65	0.65	disease	0.83	disease	0.73	disease	0.75	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.81	deleterious	-2.65	low_impact	-0.66	medium_impact	1.64	medium_impact	0.81	0.9	44.69	8.36	0.36	N	1.00	disease_causing	1	0.09	rs28479867	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6253	6253	T	A	MI.2630	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	350	117	M	K	aTa/aAa	4.06	0.99	0.05	benign	0.01	neutral	0.16	neutral	2.76	neutral	-2.07	deleterious	-2.75	medium_impact	3.24	0.66	neutral	0.41	neutral	0.69	8.75	deleterious	0.28	0.55	0.53	disease	0.69	disease	0.66	disease	0.71	disease	4	0.84	neutral	0.58	deleterious	-3	neutral	0.23	neutral	1.12	medium_impact	-0.21	medium_impact	1.89	medium_impact	0.64	0.9	15.79	29.72	0.53	P	0.69	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6254	6254	A	T	MI.2631	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	351	117	M	I	atA/atT	2.21	0.98	0	benign	0	neutral	0.31	neutral	2.86	neutral	0.27	neutral	-0.75	neutral_impact	0.36	0.69	neutral	0.69	neutral	-0.36	0.49	neutral	0.55	0.6	0.23	neutral	0.3	neutral	0.34	neutral	0.43	neutral	1	0.69	neutral	0.66	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0	medium_impact	-0.77	medium_impact	0.68	0.9	15.79	29.72	0.56	P	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6254	6254	A	C	MI.2632	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	351	117	M	I	atA/atC	2.21	0.98	0	benign	0	neutral	0.31	neutral	2.86	neutral	0.27	neutral	-0.75	neutral_impact	0.36	0.69	neutral	0.69	neutral	-0.52	0.20	neutral	0.55	0.6	0.23	neutral	0.3	neutral	0.34	neutral	0.43	neutral	1	0.69	neutral	0.66	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0	medium_impact	-0.77	medium_impact	0.68	0.9	15.79	29.72	0.57	P	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6255	6255	G	T	MI.2633	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	352	118	V	L	Gtg/Ttg	-0.57	0.05	0	benign	0	deleterious	0.01	neutral	2.9	neutral	-0.63	neutral	-1.84	medium_impact	2.21	0.59	damaging	0.53	neutral	1.55	13.61	neutral	0.46	0.55	0.3	neutral	0.73	disease	0.32	neutral	0.49	neutral	0	0.99	deleterious	0.51	deleterious	1	deleterious	0.18	neutral	2.07	high_impact	-0.92	medium_impact	0.94	medium_impact	0.65	0.9	10.92	27.38	0.46	N	0.55	polymorphism	0.79	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6255	6255	G	A	MI.2634	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	352	118	V	M	Gtg/Atg	-0.57	0.05	0	possibly_damaging	0.65	deleterious	0.01	neutral	2.7	neutral	-2.56	neutral	-1.96	medium_impact	2.38	0.62	neutral	0.61	neutral	1.63	14.01	neutral	0.42	0.55	0.53	disease	0.69	disease	0.35	neutral	0.49	neutral	0	0.99	deleterious	0.18	neutral	4	deleterious	0.51	deleterious	-1.01	low_impact	-0.92	medium_impact	1.1	medium_impact	0.70	0.9	10.92	27.38	0.39	N	0.82	polymorphism	0.76	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6255	6255	G	C	MI.2635	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	352	118	V	L	Gtg/Ctg	-0.57	0.05	0	benign	0	deleterious	0.01	neutral	2.9	neutral	-0.63	neutral	-1.84	medium_impact	2.21	0.59	damaging	0.53	neutral	1.40	12.80	neutral	0.46	0.55	0.3	neutral	0.73	disease	0.32	neutral	0.49	neutral	0	0.99	deleterious	0.51	deleterious	1	deleterious	0.18	neutral	2.07	high_impact	-0.92	medium_impact	0.94	medium_impact	0.65	0.9	10.92	27.38	0.46	N	0.55	polymorphism	0.79	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6256	6256	T	A	MI.2636	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	353	118	V	E	gTg/gAg	1.52	0.98	0	probably_damaging	0.97	deleterious	0	neutral	2.67	deleterious	-4.01	deleterious	-4.34	high_impact	3.86	0.63	neutral	0.48	neutral	4.62	24.50	deleterious	0.12	0.55	0.65	disease	0.88	disease	0.72	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-2.18	low_impact	-1.48	low_impact	2.47	high_impact	0.57	0.9	10.92	27.38	0.51	N	0.84	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6256	6256	T	C	MI.2637	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	353	118	V	A	gTg/gCg	1.52	0.98	0	benign	0.41	deleterious	0	neutral	2.75	neutral	-1.66	deleterious	-2.71	medium_impact	3.1	0.67	neutral	0.64	neutral	1.76	14.73	neutral	0.33	0.55	0.31	neutral	0.61	disease	0.57	disease	0.57	disease	1	1	deleterious	0.3	neutral	1	deleterious	0.30	neutral	-0.61	medium_impact	-1.48	low_impact	1.76	medium_impact	0.38	0.9	10.92	27.38	0.48	N	0.47	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6256	6256	T	G	MI.2638	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	353	118	V	G	gTg/gGg	1.52	0.98	0	probably_damaging	0.98	deleterious	0	neutral	2.65	deleterious	-3.68	deleterious	-5.09	medium_impact	3.4	0.62	neutral	0.6	neutral	3.65	23.20	deleterious	0.17	0.55	0.29	neutral	0.79	disease	0.62	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.69	deleterious	-2.35	low_impact	-1.48	low_impact	2.04	high_impact	0.61	0.9	10.92	27.38	0.45	N	0.71	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6258	6258	G	A	MI.2639	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	355	119	E	K	Gag/Aag	-7.97	0	0	probably_damaging	0.97	deleterious	0.01	neutral	2.87	neutral	-1.59	deleterious	-2.62	high_impact	3.73	0.48	damaging	0.36	neutral	4.31	24.00	deleterious	0.4	0.55	0.32	neutral	0.86	disease	0.52	disease	0.62	disease	2	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-2.18	low_impact	-0.92	medium_impact	2.35	high_impact	0.74	0.9	3.31	8	0.46	N	0.72	polymorphism	0.89	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8648	8648	G	T	MI.264	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	122	41	R	L	cGa/cTa	2.9	0.74	0	probably_damaging	0.99	neutral	0.07	neutral	4.2	neutral	-2.61	deleterious	-6.29	high_impact	3.8	0.58	damaging	0.36	neutral	4.15	23.80	deleterious	0.29	0.65	0.76	disease	0.91	disease	0.77	disease	0.82	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.86	deleterious	-2.65	low_impact	-0.34	medium_impact	2.16	high_impact	0.23	0.9	44.69	8.36	0.47	N	1.00	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6258	6258	G	C	MI.2640	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	355	119	E	Q	Gag/Cag	-7.97	0	0	probably_damaging	0.98	deleterious	0	neutral	2.87	neutral	-1.69	neutral	-1.95	high_impact	4.01	0.56	damaging	0.52	neutral	3.23	22.80	deleterious	0.55	0.6	0.36	neutral	0.71	disease	0.36	neutral	0.49	neutral	0	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-2.35	low_impact	-1.48	low_impact	2.6	high_impact	0.70	0.9	3.31	8	0.48	N	0.66	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6259	6259	A	T	MI.2641	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	356	119	E	V	gAg/gTg	9.15	1	0	probably_damaging	0.99	deleterious	0	neutral	2.82	deleterious	-3.32	deleterious	-4.93	high_impact	3.9	0.49	damaging	0.42	neutral	4.29	24.00	deleterious	0.25	0.55	0.56	disease	0.85	disease	0.59	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	2.5	high_impact	0.61	0.9	3.31	8	0.54	P	0.67	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6259	6259	A	C	MI.2642	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	356	119	E	A	gAg/gCg	9.15	1	0	probably_damaging	0.98	deleterious	0	neutral	2.86	neutral	-1.95	deleterious	-4	high_impact	4.01	0.59	damaging	0.5	neutral	3.74	23.30	deleterious	0.31	0.55	0.38	neutral	0.73	disease	0.5	neutral	0.47	neutral	1	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.35	low_impact	-1.48	low_impact	2.6	high_impact	0.68	0.9	3.31	8	0.5	P	0.71	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6259	6259	A	G	MI.2643	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	356	119	E	G	gAg/gGg	9.15	1	0	probably_damaging	0.99	neutral	0.1	neutral	3.32	neutral	1.55	deleterious	-4.13	low_impact	1.48	0.47	damaging	0.59	neutral	4.24	23.90	deleterious	0.38	0.55	0.24	neutral	0.62	disease	0.39	neutral	0.4	neutral	2	1	deleterious	0.06	neutral	-2	neutral	0.73	deleterious	-2.64	low_impact	-0.34	medium_impact	0.27	medium_impact	0.55	0.9	3.31	8	0.61	P	0.67	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6260	6260	G	T	MI.2644	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	357	119	E	D	gaG/gaT	8.69	1	0.01	possibly_damaging	0.9	neutral	0.21	neutral	2.91	neutral	-0.87	neutral	-1.53	low_impact	1.7	0.45	damaging	0.6	neutral	2.59	20.20	deleterious	0.44	0.55	0.4	neutral	0.58	disease	0.28	neutral	0.44	neutral	1	0.93	neutral	0.16	neutral	-3	neutral	0.69	deleterious	-1.65	low_impact	-0.13	medium_impact	0.47	medium_impact	0.80	0.9	3.31	8	0.7	P	0.69	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6260	6260	G	C	MI.2645	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	357	119	E	D	gaG/gaC	8.69	1	0.01	possibly_damaging	0.9	neutral	0.21	neutral	2.91	neutral	-0.87	neutral	-1.53	low_impact	1.7	0.45	damaging	0.6	neutral	2.43	19.00	deleterious	0.44	0.55	0.4	neutral	0.58	disease	0.28	neutral	0.44	neutral	1	0.93	neutral	0.16	neutral	-3	neutral	0.69	deleterious	-1.65	low_impact	-0.13	medium_impact	0.47	medium_impact	0.80	0.9	3.31	8	0.71	P	0.69	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6261	6261	G	C	MI.2646	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	358	120	A	P	Gcc/Ccc	1.75	1	0.01	probably_damaging	1	neutral	0.11	neutral	2.77	neutral	-2.19	neutral	-1.11	low_impact	1.42	0.59	damaging	0.35	neutral	2.13	17.05	deleterious	0.2	0.55	0.54	disease	0.76	disease	0.27	neutral	0.53	disease	1	1	deleterious	0.06	neutral	-2	neutral	0.82	deleterious	-3.58	low_impact	-0.31	medium_impact	0.21	medium_impact	0.68	0.9	2.92	8.24	0.48	N	0.85	disease_causing	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6261	6261	G	A	MI.2647	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	358	120	A	T	Gcc/Acc	1.75	1	0.01	probably_damaging	0.99	neutral	0.15	neutral	2.82	neutral	-0.52	neutral	0.27	neutral_impact	-0.4	0.61	neutral	0.57	neutral	1.08	11.11	neutral	0.38	0.55	0.26	neutral	0.25	neutral	0.16	neutral	0.43	neutral	1	1	deleterious	0.08	neutral	-2	neutral	0.66	deleterious	-2.64	low_impact	-0.23	medium_impact	-1.47	low_impact	0.68	0.9	2.92	8.24	0.69	P	0.20	disease_causing	0.91	0.01	rs201262114	Likely_benign	not_provided	237398	MedGen:CN517202	.	.	CPD	0.15	G6261A	Prostate Cancer / LHON	+	-	Reported	3	N	P	N,P	damaging
chrM	6261	6261	G	T	MI.2648	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	358	120	A	S	Gcc/Tcc	1.75	1	0.01	probably_damaging	0.99	neutral	0.66	neutral	2.82	neutral	-0.19	neutral	1.09	neutral_impact	-1.8	0.68	neutral	0.83	neutral	-1.00	0.02	neutral	0.32	0.55	0.19	neutral	0.11	neutral	0.11	neutral	0.26	neutral	5	0.99	deleterious	0.34	neutral	-2	neutral	0.64	deleterious	-2.64	low_impact	0.35	medium_impact	-2.76	low_impact	0.73	0.9	2.92	8.24	0.46	N	0.64	disease_causing	0.82	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6262	6262	C	A	MI.2649	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	359	120	A	D	gCc/gAc	7.53	1	0	probably_damaging	1	neutral	0.11	neutral	2.78	neutral	-0.77	neutral	-0.46	neutral_impact	0.72	0.61	neutral	0.35	neutral	1.62	13.96	neutral	0.22	0.55	0.36	neutral	0.7	disease	0.22	neutral	0.46	neutral	1	1	deleterious	0.06	neutral	-2	neutral	0.74	deleterious	-3.58	low_impact	-0.31	medium_impact	-0.43	medium_impact	0.61	0.9	2.92	8.24	0.53	P	0.89	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8650	8650	C	A	MI.265	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	124	42	L	M	Cta/Ata	-10.75	0	0	probably_damaging	1	neutral	0.15	neutral	4.3	neutral	-0.88	neutral	-1.29	low_impact	1.92	0.89	neutral	0.85	neutral	2.49	19.41	deleterious	0.32	0.65	0.66	disease	0.21	neutral	0.24	neutral	0.47	neutral	1	1	deleterious	0.08	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	-0.13	medium_impact	0.55	medium_impact	0.81	0.9	25.22	18.79	0.5	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6262	6262	C	T	MI.2650	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	359	120	A	V	gCc/gTc	7.53	1	0	probably_damaging	0.99	neutral	0.07	neutral	2.75	neutral	-1.26	neutral	-1.03	neutral_impact	0.36	0.61	neutral	0.38	neutral	1.39	12.76	neutral	0.35	0.55	0.26	neutral	0.37	neutral	0.27	neutral	0.45	neutral	1	1	deleterious	0.04	neutral	-2	neutral	0.67	deleterious	-2.64	low_impact	-0.43	medium_impact	-0.77	medium_impact	0.58	0.9	2.92	8.24	0.62	P	0.75	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6262	6262	C	G	MI.2651	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	359	120	A	G	gCc/gGc	7.53	1	0	probably_damaging	0.97	neutral	0.25	neutral	2.9	neutral	1.06	neutral	-0.57	neutral_impact	-0.58	0.65	neutral	0.54	neutral	0.80	9.46	deleterious	0.29	0.55	0.16	neutral	0.25	neutral	0.16	neutral	0.42	neutral	2	0.98	neutral	0.14	neutral	-2	neutral	0.64	deleterious	-2.18	low_impact	-0.07	medium_impact	-1.64	low_impact	0.68	0.9	2.92	8.24	0.6	P	0.56	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6264	6264	G	C	MI.2652	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	361	121	G	R	Gga/Cga	-12.13	0	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-2.32	deleterious	-6.6	high_impact	5.28	0.44	damaging	0.02	damaging	3.86	23.50	deleterious	0.2	0.55	0.42	neutral	0.86	disease	0.85	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.87	0.9	2.14	6.66	0.57	P	0.95	polymorphism	0.72	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6264	6264	G	T	MI.2653	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	361	121	G	W	Gga/Tga	-12.13	0	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-5.98	deleterious	-6.61	high_impact	5.28	0.42	damaging	0.02	damaging	4.32	24.00	deleterious	0.18	0.55	0.92	disease	0.88	disease	0.77	disease	0.62	disease	2	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.44	0.9	2.14	6.66	0.5	P	0.83	polymorphism	0.62	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6265	6265	G	T	MI.2654	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	362	121	G	V	gGa/gTa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.77	deleterious	-3.07	deleterious	-7.43	high_impact	5.28	0.48	damaging	0.03	damaging	3.71	23.30	deleterious	0.19	0.55	0.63	disease	0.86	disease	0.74	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.56	0.9	2.14	6.66	0.65	P	0.93	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6265	6265	G	A	MI.2655	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	362	121	G	E	gGa/gAa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-1.77	deleterious	-6.6	high_impact	4.92	0.38	damaging	0.02	damaging	3.77	23.40	deleterious	0.27	0.55	0.46	neutral	0.85	disease	0.83	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.51	0.9	2.14	6.66	0.76	P	0.93	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6265	6265	G	C	MI.2656	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	362	121	G	A	gGa/gCa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.91	neutral	-1.67	deleterious	-4.95	high_impact	4.38	0.58	damaging	0.04	damaging	3.01	22.30	deleterious	0.33	0.55	0.39	neutral	0.71	disease	0.72	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.62	0.9	2.14	6.66	0.51	P	0.64	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6267	6267	G	T	MI.2657	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	364	122	A	S	Gca/Tca	-20	0	0	benign	0.23	neutral	0.2	neutral	2.74	neutral	-2.02	neutral	-1.85	low_impact	1.59	0.65	neutral	0.56	neutral	2.31	18.21	deleterious	0.44	0.55	0.42	neutral	0.55	disease	0.32	neutral	0.24	neutral	5	0.76	neutral	0.49	deleterious	-6	neutral	0.28	neutral	-0.26	medium_impact	-0.14	medium_impact	0.37	medium_impact	0.83	0.9	11.5	11.09	0.45	N	0.64	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6267	6267	G	C	MI.2658	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	364	122	A	P	Gca/Cca	-20	0	0	probably_damaging	0.93	neutral	0.16	neutral	2.64	neutral	-1.82	deleterious	-3.11	medium_impact	2.16	0.59	damaging	0.38	neutral	3.74	23.30	deleterious	0.32	0.55	0.24	neutral	0.77	disease	0.32	neutral	0.23	neutral	5	0.96	neutral	0.12	neutral	1	deleterious	0.73	deleterious	-1.81	low_impact	-0.21	medium_impact	0.9	medium_impact	0.75	0.9	11.5	11.09	0.38	N	0.85	polymorphism	0.8	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6267	6267	G	A	MI.2659	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	364	122	A	T	Gca/Aca	-20	0	0	benign	0.01	neutral	0.1	neutral	2.67	neutral	-2.4	neutral	-1.81	low_impact	1.92	0.54	damaging	0.59	neutral	3.63	23.20	deleterious	0.5	0.55	0.37	neutral	0.55	disease	0.35	neutral	0.22	neutral	6	0.9	neutral	0.55	deleterious	-6	neutral	0.21	neutral	1.12	medium_impact	-0.34	medium_impact	0.67	medium_impact	0.76	0.9	11.5	11.09	0.58	P	0.20	polymorphism	0.93	0.03	rs202216551	.	.	.	.	pancreatic cancer cell line	.	.	0.89	G6267A	Prostate Cancer	+	-	Reported	1	N	P	N,P	damaging
chrM	8650	8650	C	G	MI.266	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	124	42	L	V	Cta/Gta	-10.75	0	0	probably_damaging	0.99	neutral	0.15	neutral	4.3	neutral	-0.87	neutral	-1.87	medium_impact	2.21	0.89	neutral	0.84	neutral	2.14	17.09	deleterious	0.39	0.65	0.42	neutral	0.31	neutral	0.31	neutral	0.47	neutral	1	0.99	deleterious	0.08	neutral	1	deleterious	0.71	deleterious	-2.65	low_impact	-0.13	medium_impact	0.8	medium_impact	0.66	0.9	25.22	18.79	0.51	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6268	6268	C	A	MI.2660	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	365	122	A	E	gCa/gAa	7.3	1	0	probably_damaging	0.94	deleterious	0	neutral	2.73	neutral	-2.96	deleterious	-3.09	high_impact	4.57	0.63	neutral	0.45	neutral	4.38	24.10	deleterious	0.26	0.55	0.61	disease	0.79	disease	0.68	disease	0.68	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-1.88	low_impact	-1.48	low_impact	3.12	high_impact	0.76	0.9	11.5	11.09	0.58	P	0.76	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6268	6268	C	T	MI.2661	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	365	122	A	V	gCa/gTa	7.3	1	0	benign	0.01	neutral	0.32	neutral	2.66	neutral	-2.13	neutral	-1.17	neutral_impact	0.56	0.61	neutral	0.71	neutral	0.77	9.25	deleterious	0.44	0.55	0.29	neutral	0.3	neutral	0.32	neutral	0.43	neutral	1	0.67	neutral	0.66	deleterious	-6	neutral	0.17	neutral	1.12	medium_impact	0.01	medium_impact	-0.58	medium_impact	0.64	0.9	11.5	11.09	0.64	P	0.75	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6268	6268	C	G	MI.2662	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	365	122	A	G	gCa/gGa	7.3	1	0	benign	0.15	deleterious	0.03	neutral	2.7	deleterious	-3.39	deleterious	-2.87	medium_impact	3.15	0.62	neutral	0.58	neutral	2.24	17.76	deleterious	0.37	0.55	0.52	disease	0.6	disease	0.58	disease	0.64	disease	3	0.97	neutral	0.44	neutral	1	deleterious	0.29	neutral	-0.05	medium_impact	-0.65	medium_impact	1.81	medium_impact	0.80	0.9	11.5	11.09	0.55	P	0.56	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6270	6270	G	T	MI.2663	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	367	123	G	W	Gga/Tga	-16.07	0	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-6.77	deleterious	-6.63	high_impact	5.21	0.41	damaging	0.02	damaging	4.35	24.10	deleterious	0.19	0.55	0.88	disease	0.84	disease	0.74	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.71	high_impact	0.44	0.9	2.73	6.66	0.43	N	0.83	polymorphism	0.74	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6270	6270	G	C	MI.2664	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	367	123	G	R	Gga/Cga	-16.07	0	0	probably_damaging	1	deleterious	0	neutral	2.49	neutral	-2.8	deleterious	-6.63	high_impact	5.21	0.43	damaging	0.02	damaging	3.89	23.50	deleterious	0.18	0.55	0.33	neutral	0.83	disease	0.75	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.71	high_impact	0.75	0.9	2.73	6.66	0.48	N	0.95	polymorphism	0.82	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6271	6271	G	A	MI.2665	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	368	123	G	E	gGa/gAa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.53	neutral	-2.01	deleterious	-6.63	high_impact	4.41	0.37	damaging	0.02	damaging	3.81	23.40	deleterious	0.23	0.55	0.3	neutral	0.82	disease	0.69	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.38	0.9	2.73	6.66	0.61	P	0.93	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6271	6271	G	C	MI.2666	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	368	123	G	A	gGa/gCa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.55	neutral	-1.78	deleterious	-4.97	medium_impact	3.24	0.58	damaging	0.04	damaging	3.04	22.30	deleterious	0.26	0.55	0.36	neutral	0.67	disease	0.65	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	1.89	medium_impact	0.44	0.9	2.73	6.66	0.46	N	0.64	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6271	6271	G	T	MI.2667	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	368	123	G	V	gGa/gTa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-3.77	deleterious	-7.46	high_impact	5.21	0.47	damaging	0.03	damaging	3.67	23.20	deleterious	0.19	0.55	0.53	disease	0.84	disease	0.7	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.71	high_impact	0.46	0.9	2.73	6.66	0.61	P	0.93	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6273	6273	A	G	MI.2668	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	370	124	T	A	Aca/Gca	-7.04	0	0	probably_damaging	0.98	deleterious	0.03	neutral	2.81	neutral	-1.36	deleterious	-3.15	medium_impact	2.5	0.72	neutral	0.06	damaging	3.39	23.00	deleterious	0.5	0.55	0.23	neutral	0.45	neutral	0.38	neutral	0.36	neutral	3	1	deleterious	0.03	neutral	5	deleterious	0.69	deleterious	-2.35	low_impact	-0.65	medium_impact	1.21	medium_impact	0.33	0.9	2.53	6.75	0.3	N	0.69	polymorphism	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6273	6273	A	C	MI.2669	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	370	124	T	P	Aca/Cca	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-3.82	deleterious	-4.22	high_impact	4.79	0.59	damaging	0.07	damaging	3.46	23.00	deleterious	0.27	0.55	0.75	disease	0.73	disease	0.5	neutral	0.49	neutral	0	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.27	0.9	2.53	6.75	0.56	P	0.92	polymorphism	0.88	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8651	8651	T	G	MI.267	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	125	42	L	R	cTa/cGa	-7.04	0	0	probably_damaging	1	neutral	0.06	neutral	4.21	deleterious	-3.05	deleterious	-4.75	high_impact	3.62	0.75	neutral	0.12	damaging	4.05	23.70	deleterious	0.19	0.65	0.82	disease	0.79	disease	0.72	disease	0.77	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.38	medium_impact	2.01	high_impact	0.54	0.9	25.22	18.79	0.28	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6273	6273	A	T	MI.2670	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	370	124	T	S	Aca/Tca	-7.04	0	0	probably_damaging	0.98	deleterious	0.03	neutral	2.73	neutral	-2.45	deleterious	-2.68	medium_impact	3.29	0.69	neutral	0.07	damaging	3.23	22.80	deleterious	0.39	0.55	0.53	disease	0.59	disease	0.51	disease	0.4	neutral	2	1	deleterious	0.03	neutral	5	deleterious	0.75	deleterious	-2.35	low_impact	-0.65	medium_impact	1.94	medium_impact	0.32	0.9	2.53	6.75	0.27	N	0.79	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6274	6274	C	T	MI.2671	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	371	124	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.58	deleterious	-4.37	high_impact	4.58	0.7	neutral	0.05	damaging	3.91	23.50	deleterious	0.33	0.55	0.63	disease	0.69	disease	0.66	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.49	0.9	2.53	6.75	0.53	P	0.96	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6274	6274	C	A	MI.2672	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	371	124	T	K	aCa/aAa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-1.94	deleterious	-4.34	high_impact	5.13	0.64	neutral	0.04	damaging	4.42	24.20	deleterious	0.3	0.55	0.64	disease	0.77	disease	0.76	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.57	0.9	2.53	6.75	0.75	P	0.88	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6276	6276	G	T	MI.2673	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	373	125	G	C	Ggt/Tgt	-4.96	0	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-5.93	deleterious	-7.47	high_impact	5.29	0.4	damaging	0.03	damaging	4.07	23.70	deleterious	0.18	0.55	0.83	disease	0.88	disease	0.67	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.56	0.9	3.51	6.82	0.49	P	0.98	polymorphism	0.7	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6276	6276	G	A	MI.2674	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	373	125	G	S	Ggt/Agt	-4.96	0	0	probably_damaging	1	neutral	0.09	neutral	2.54	neutral	-2.85	deleterious	-4.98	high_impact	3.98	0.48	damaging	0.05	damaging	4.08	23.70	deleterious	0.25	0.55	0.58	disease	0.8	disease	0.63	disease	0.56	disease	1	1	deleterious	0.05	neutral	2	deleterious	0.85	deleterious	-3.58	low_impact	-0.37	medium_impact	2.58	high_impact	0.63	0.9	3.51	6.82	0.33	N	0.73	polymorphism	0.91	0.36	rs879156031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6276	6276	G	C	MI.2675	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	373	125	G	R	Ggt/Cgt	-4.96	0	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.63	deleterious	-6.64	high_impact	5.29	0.45	damaging	0.03	damaging	3.90	23.50	deleterious	0.22	0.55	0.75	disease	0.86	disease	0.82	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.75	0.9	3.51	6.82	0.61	P	0.95	polymorphism	0.82	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6277	6277	G	T	MI.2676	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	374	125	G	V	gGt/gTt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.15	deleterious	-7.47	high_impact	5.29	0.5	damaging	0.04	damaging	3.70	23.30	deleterious	0.18	0.55	0.51	disease	0.87	disease	0.74	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.55	0.9	3.51	6.82	0.62	P	0.93	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6277	6277	G	A	MI.2677	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	374	125	G	D	gGt/gAt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.16	deleterious	-5.81	high_impact	4.75	0.28	damaging	0.03	damaging	3.73	23.30	deleterious	0.18	0.55	0.82	disease	0.86	disease	0.76	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.41	0.9	3.51	6.82	0.85	P	0.97	disease_causing_automatic	1	0.50	rs281865417	Pathogenic	Familial_colorectal_cancer	24711	MedGen:CN029768	colonic crypts	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	6277	6277	G	C	MI.2678	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	374	125	G	A	gGt/gCt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.45	deleterious	-4.98	high_impact	4.32	0.6	damaging	0.06	damaging	3.00	22.20	deleterious	0.25	0.55	0.56	disease	0.72	disease	0.71	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.89	high_impact	0.70	0.9	3.51	6.82	0.51	P	0.64	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6279	6279	T	G	MI.2679	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	376	126	W	G	Tga/Gga	-14.91	0	0	probably_damaging	1	deleterious	0	neutral	2	deleterious	-7.74	deleterious	-10.79	high_impact	5.31	0.61	neutral	0.08	damaging	3.88	23.50	deleterious	0.18	0.55	0.41	neutral	0.86	disease	0.81	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.21	0.9	1.95	6.71	0.49	N	0.89	polymorphism	0.97	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8651	8651	T	C	MI.268	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	125	42	L	P	cTa/cCa	-7.04	0	0	probably_damaging	1	neutral	0.06	neutral	4.2	deleterious	-3.68	deleterious	-5.15	medium_impact	3.07	0.75	neutral	0.17	damaging	3.77	23.40	deleterious	0.16	0.65	0.87	disease	0.82	disease	0.73	disease	0.78	disease	6	1	deleterious	0.03	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	-0.38	medium_impact	1.53	medium_impact	0.43	0.9	25.22	18.79	0.25	N	0.95	polymorphism	0.85	0.11	.	not_provided	not_provided	434782	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6279	6279	T	C	MI.2680	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	376	126	W	R	Tga/Cga	-14.91	0	0	probably_damaging	1	deleterious	0	neutral	2	deleterious	-7.32	deleterious	-11.62	high_impact	5.31	0.61	neutral	0.08	damaging	3.56	23.10	deleterious	0.22	0.55	0.9	disease	0.93	disease	0.84	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.17	0.9	1.95	6.71	0.5	N	0.98	polymorphism	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6280	6280	G	T	MI.2681	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	377	126	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.13	deleterious	-5.29	deleterious	-10.79	high_impact	5.31	0.56	damaging	0.1	damaging	4.15	23.80	deleterious	0.15	0.55	0.78	disease	0.87	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.16	0.9	1.95	6.71	0.59	P	0.95	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6280	6280	G	C	MI.2682	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	377	126	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.01	deleterious	-6.48	deleterious	-11.62	high_impact	4.76	0.68	neutral	0.09	damaging	3.89	23.50	deleterious	0.16	0.55	0.86	disease	0.94	disease	0.79	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.17	0.9	1.95	6.71	0.52	P	0.89	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6281	6281	A	T	MI.2683	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	378	126	W	C	tgA/tgT	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2	deleterious	-8.33	deleterious	-10.79	high_impact	5.31	0.6	damaging	0.07	damaging	4.04	23.70	deleterious	0.21	0.55	0.95	disease	0.93	disease	0.81	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.19	0.9	1.95	6.71	0.53	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6281	6281	A	C	MI.2684	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	378	126	W	C	tgA/tgC	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2	deleterious	-8.33	deleterious	-10.79	high_impact	5.31	0.6	damaging	0.07	damaging	3.92	23.50	deleterious	0.21	0.55	0.95	disease	0.93	disease	0.81	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.19	0.9	1.95	6.71	0.52	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6282	6282	A	T	MI.2685	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	379	127	T	S	Aca/Tca	0.82	0.99	0	probably_damaging	0.99	deleterious	0	neutral	2.52	deleterious	-3.64	deleterious	-3.32	high_impact	5.28	0.74	neutral	0.17	damaging	3.27	22.80	deleterious	0.33	0.55	0.68	disease	0.66	disease	0.68	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.78	high_impact	0.77	0.9	2.34	6.87	0.67	P	0.79	disease_causing	0.97	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6282	6282	A	G	MI.2686	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	379	127	T	A	Aca/Gca	0.82	0.99	0	probably_damaging	0.99	deleterious	0	neutral	2.52	deleterious	-3	deleterious	-4.15	high_impact	4.93	0.61	neutral	0.16	damaging	3.43	23.00	deleterious	0.39	0.55	0.59	disease	0.61	disease	0.69	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	3.45	high_impact	0.63	0.9	2.34	6.87	0.67	P	0.69	disease_causing	0.99	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6282	6282	A	C	MI.2687	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	379	127	T	P	Aca/Cca	0.82	0.99	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-5.24	deleterious	-4.98	high_impact	4.93	0.59	damaging	0.13	damaging	3.48	23.10	deleterious	0.15	0.55	0.84	disease	0.74	disease	0.68	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.65	0.9	2.34	6.87	0.63	P	0.92	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6283	6283	C	T	MI.2688	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	380	127	T	M	aCa/aTa	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-3.83	deleterious	-4.98	high_impact	4.73	0.75	neutral	0.13	damaging	3.92	23.50	deleterious	0.27	0.55	0.36	neutral	0.73	disease	0.7	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	3.27	high_impact	0.75	0.9	2.34	6.87	0.63	P	0.96	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6283	6283	C	A	MI.2689	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	380	127	T	K	aCa/aAa	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.37	deleterious	-4.98	high_impact	5.28	0.63	neutral	0.11	damaging	4.42	24.20	deleterious	0.15	0.55	0.76	disease	0.79	disease	0.77	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.73	0.9	2.34	6.87	0.74	P	0.88	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8651	8651	T	A	MI.269	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	125	42	L	Q	cTa/cAa	-7.04	0	0	probably_damaging	1	neutral	0.05	neutral	4.2	deleterious	-3.19	deleterious	-4.62	medium_impact	2.93	0.8	neutral	0.16	damaging	4.05	23.70	deleterious	0.21	0.65	0.84	disease	0.69	disease	0.59	disease	0.7	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.43	medium_impact	1.41	medium_impact	0.51	0.9	25.22	18.79	0.27	N	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6285	6285	G	T	MI.2690	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	382	128	V	F	Gtc/Ttc	-11.67	0	0	possibly_damaging	0.7	neutral	0.07	neutral	3	neutral	0.36	deleterious	-3.71	medium_impact	3.19	0.53	damaging	0.5	neutral	3.64	23.20	deleterious	0.21	0.55	0.23	neutral	0.87	disease	0.45	neutral	0.7	disease	4	0.94	neutral	0.19	neutral	0	NA	0.67	deleterious	-1.1	low_impact	-0.43	medium_impact	1.85	medium_impact	0.71	0.9	0.97	7.02	0.46	N	0.86	polymorphism	0.82	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6285	6285	G	A	MI.2691	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	382	128	V	I	Gtc/Atc	-11.67	0	0	benign	0.1	neutral	0.22	neutral	2.93	neutral	-0.12	neutral	-0.46	low_impact	1.22	0.53	damaging	0.64	neutral	0.57	7.94	deleterious	0.52	0.6	0.34	neutral	0.25	neutral	0.22	neutral	0.41	neutral	2	0.75	neutral	0.56	deleterious	-6	neutral	0.20	neutral	0.14	medium_impact	-0.11	medium_impact	0.03	medium_impact	0.95	1	0.97	7.02	0.63	P	0.24	polymorphism	0.99	0.02	rs878947044	.	.	.	.	.	.	.	.	G6285A	Prostate Cancer	+	-	Reported	1	N	P	N,P	damaging
chrM	6285	6285	G	C	MI.2692	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	382	128	V	L	Gtc/Ctc	-11.67	0	0	benign	0	neutral	0.09	neutral	3.02	neutral	0.36	neutral	-2.01	low_impact	1.29	0.58	damaging	0.52	neutral	1.51	13.38	neutral	0.45	0.55	0.19	neutral	0.52	disease	0.24	neutral	0.4	neutral	2	0.91	neutral	0.55	deleterious	-6	neutral	0.17	neutral	2.07	high_impact	-0.37	medium_impact	0.09	medium_impact	0.84	0.9	0.97	7.02	0.52	N	0.55	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6286	6286	T	C	MI.2693	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	383	128	V	A	gTc/gCc	6.14	1	0	possibly_damaging	0.55	deleterious	0	neutral	2.93	neutral	0.28	deleterious	-3.25	medium_impact	2.32	0.56	damaging	0.61	neutral	3.21	22.70	deleterious	0.32	0.55	0.31	neutral	0.57	disease	0.6	disease	0.54	disease	1	1	deleterious	0.23	neutral	4	deleterious	0.52	deleterious	-0.84	medium_impact	-1.48	low_impact	1.04	medium_impact	0.47	0.9	0.97	7.02	0.54	P	0.47	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6286	6286	T	A	MI.2694	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	383	128	V	D	gTc/gAc	6.14	1	0	probably_damaging	0.93	deleterious	0	neutral	2.83	deleterious	-3.62	deleterious	-5.58	high_impact	4.74	0.59	damaging	0.49	neutral	4.54	24.30	deleterious	0.07	0.55	0.78	disease	0.84	disease	0.7	disease	0.74	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.82	deleterious	-1.81	low_impact	-1.48	low_impact	3.28	high_impact	0.64	0.9	0.97	7.02	0.67	P	0.83	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6286	6286	T	G	MI.2695	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	383	128	V	G	gTc/gGc	6.14	1	0	possibly_damaging	0.9	deleterious	0	neutral	2.85	neutral	-1.61	deleterious	-5.73	high_impact	3.69	0.58	damaging	0.62	neutral	3.68	23.30	deleterious	0.12	0.55	0.52	disease	0.7	disease	0.62	disease	0.64	disease	3	1	deleterious	0.05	neutral	5	deleterious	0.75	deleterious	-1.65	low_impact	-1.48	low_impact	2.31	high_impact	0.54	0.9	0.97	7.02	0.56	P	0.71	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6288	6288	T	C	MI.2696	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	385	129	Y	H	Tac/Cac	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.31	deleterious	-7.29	deleterious	-4.16	high_impact	4.96	0.6	neutral	0.33	neutral	3.47	23.00	deleterious	0.2	0.55	0.88	disease	0.75	disease	0.85	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.31	0.9	2.92	6.86	0.62	P	0.61	polymorphism	0.99	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6288	6288	T	G	MI.2697	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	385	129	Y	D	Tac/Gac	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.3	deleterious	-8.85	deleterious	-8.33	high_impact	5.3	0.55	damaging	0.37	neutral	3.83	23.40	deleterious	0.13	0.55	0.96	disease	0.84	disease	0.85	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.22	0.9	2.92	6.86	0.5	P	0.98	polymorphism	0.92	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6288	6288	T	A	MI.2698	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	385	129	Y	N	Tac/Aac	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.31	deleterious	-7.61	deleterious	-7.5	high_impact	4.75	0.53	damaging	0.43	neutral	3.91	23.50	deleterious	0.18	0.55	0.94	disease	0.85	disease	0.75	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.21	0.9	2.92	6.86	0.49	P	0.94	polymorphism	0.89	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6289	6289	A	G	MI.2699	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	386	129	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.3	deleterious	-9.38	deleterious	-7.5	high_impact	5.3	0.56	damaging	0.28	neutral	3.97	23.60	deleterious	0.2	0.55	0.97	disease	0.85	disease	0.82	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.18	0.9	2.92	6.86	0.58	P	0.89	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8537	8537	A	G	MI.27	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	11	4	N	S	aAt/aGt	5.91	1	0.01	benign	0.01	neutral	0.86	neutral	4.64	neutral	0.19	neutral	-2.47	neutral_impact	0.68	0.83	neutral	0.64	neutral	2.56	19.88	deleterious	0.7	0.75	0.6	disease	0.04	neutral	0.23	neutral	0.33	neutral	3	0.12	neutral	0.93	deleterious	-6	neutral	0.10	neutral	1.14	medium_impact	0.74	medium_impact	-0.52	medium_impact	0.22	0.9	41.59	7.51	0.57	P	0.33	disease_causing	0.89	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8653	8653	A	C	MI.270	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	127	43	I	L	Atc/Ctc	-8.89	0	0	benign	0.06	neutral	0.7	neutral	4.4	neutral	0.17	neutral	-0.76	neutral_impact	-0.43	0.87	neutral	0.79	neutral	-0.91	0.03	neutral	0.47	0.65	0.43	neutral	0.18	neutral	0.13	neutral	0.31	neutral	4	0.22	neutral	0.82	deleterious	-6	neutral	0.14	neutral	0.38	medium_impact	0.5	medium_impact	-1.47	low_impact	0.59	0.9	31.42	20.88	0.44	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6289	6289	A	C	MI.2700	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	386	129	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.33	deleterious	-7.72	deleterious	-7.49	high_impact	4.96	0.65	neutral	0.49	neutral	4.11	23.80	deleterious	0.17	0.55	0.92	disease	0.83	disease	0.77	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.30	0.9	2.92	6.86	0.65	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6289	6289	A	T	MI.2701	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	386	129	Y	F	tAc/tTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.35	deleterious	-4.88	deleterious	-3.33	high_impact	4.96	0.53	damaging	0.35	neutral	3.89	23.50	deleterious	0.21	0.55	0.65	disease	0.79	disease	0.73	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.48	0.9	2.92	6.86	0.74	P	0.50	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6291	6291	C	G	MI.2702	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	388	130	P	A	Cct/Gct	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-1.89	deleterious	-6.67	high_impact	3.59	0.65	neutral	0.13	damaging	2.98	22.20	deleterious	0.21	0.55	0.35	neutral	0.67	disease	0.58	disease	0.54	disease	1	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.22	high_impact	0.76	0.9	3.31	7.21	0.31	N	0.76	polymorphism	0.95	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6291	6291	C	A	MI.2703	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	388	130	P	T	Cct/Act	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-2.52	deleterious	-6.67	medium_impact	3.49	0.6	neutral	0.09	damaging	3.76	23.30	deleterious	0.23	0.55	0.33	neutral	0.83	disease	0.65	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.12	high_impact	0.68	0.9	3.31	7.21	0.27	N	0.80	polymorphism	0.92	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6291	6291	C	T	MI.2704	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	388	130	P	S	Cct/Tct	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-2.73	deleterious	-6.67	high_impact	4.21	0.68	neutral	0.11	damaging	3.77	23.40	deleterious	0.26	0.55	0.46	neutral	0.8	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.79	high_impact	0.34	0.9	3.31	7.21	0.33	N	0.85	polymorphism	0.92	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6292	6292	C	T	MI.2705	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	389	130	P	L	cCt/cTt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.66	neutral	-2.24	deleterious	-8.34	high_impact	4.91	0.49	damaging	0.11	damaging	4.23	23.90	deleterious	0.25	0.55	0.38	neutral	0.84	disease	0.65	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.46	0.9	3.31	7.21	0.59	P	0.87	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6292	6292	C	G	MI.2706	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	389	130	P	R	cCt/cGt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-3.21	deleterious	-7.5	high_impact	5.25	0.58	damaging	0.08	damaging	3.54	23.10	deleterious	0.17	0.55	0.63	disease	0.85	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.49	0.9	3.31	7.21	0.68	P	0.90	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6292	6292	C	A	MI.2707	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	389	130	P	H	cCt/cAt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-4.32	deleterious	-7.5	high_impact	5.25	0.6	damaging	0.07	damaging	3.85	23.40	deleterious	0.19	0.55	0.73	disease	0.81	disease	0.75	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.52	0.9	3.31	7.21	0.67	P	0.81	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6294	6294	C	T	MI.2708	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	391	131	P	S	Ccc/Tcc	-20	0	0	probably_damaging	1	deleterious	0	neutral	0.8	deleterious	-6.85	deleterious	-6.67	high_impact	4.76	0.65	neutral	0.52	neutral	3.85	23.40	deleterious	0.26	0.55	0.58	disease	0.8	disease	0.62	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.42	0.9	2.14	6.67	0.57	P	0.85	polymorphism	0.93	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6294	6294	C	G	MI.2709	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	391	131	P	A	Ccc/Gcc	-20	0	0	probably_damaging	1	deleterious	0	neutral	0.8	deleterious	-6.95	deleterious	-6.67	high_impact	4.96	0.7	neutral	0.53	neutral	3.04	22.40	deleterious	0.18	0.55	0.65	disease	0.69	disease	0.71	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.63	0.9	2.14	6.67	0.6	P	0.76	polymorphism	0.96	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8653	8653	A	T	MI.271	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	127	43	I	F	Atc/Ttc	-8.89	0	0	possibly_damaging	0.56	neutral	0.71	neutral	4.38	neutral	-0.27	neutral	-2.34	low_impact	1.07	0.9	neutral	0.56	neutral	2.05	16.50	deleterious	0.49	0.65	0.74	disease	0.47	neutral	0.17	neutral	0.61	disease	2	0.48	neutral	0.58	deleterious	-3	neutral	0.58	deleterious	-0.86	medium_impact	0.51	medium_impact	-0.18	medium_impact	0.59	0.9	31.42	20.88	0.33	N	0.44	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6294	6294	C	A	MI.2710	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	391	131	P	T	Ccc/Acc	-20	0	0	probably_damaging	1	deleterious	0	neutral	0.8	deleterious	-6.98	deleterious	-6.67	high_impact	4.5	0.65	neutral	0.41	neutral	3.64	23.20	deleterious	0.2	0.55	0.74	disease	0.83	disease	0.72	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.66	0.9	2.14	6.67	0.41	N	0.80	polymorphism	0.94	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6295	6295	C	A	MI.2711	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	392	131	P	H	cCc/cAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	0.76	deleterious	-10.06	deleterious	-7.51	high_impact	5.31	0.65	neutral	0.38	neutral	3.96	23.60	deleterious	0.15	0.55	0.91	disease	0.81	disease	0.8	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.61	0.9	2.14	6.67	0.61	P	0.81	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6295	6295	C	G	MI.2712	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	392	131	P	R	cCc/cGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	0.77	deleterious	-8.77	deleterious	-7.51	high_impact	5.31	0.66	neutral	0.38	neutral	3.54	23.10	deleterious	0.16	0.55	0.84	disease	0.85	disease	0.82	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.56	0.9	2.14	6.67	0.61	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6295	6295	C	T	MI.2713	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	392	131	P	L	cCc/cTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	0.78	deleterious	-7.72	deleterious	-8.34	high_impact	5.31	0.62	neutral	0.44	neutral	4.33	24.00	deleterious	0.21	0.55	0.39	neutral	0.84	disease	0.7	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.77	0.9	2.14	6.67	0.55	P	0.87	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6297	6297	T	A	MI.2714	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	394	132	L	M	Tta/Ata	-13.98	0	0	probably_damaging	1	deleterious	0	neutral	1.96	deleterious	-4.27	neutral	-1.67	high_impact	5.3	0.64	neutral	0.16	damaging	3.54	23.10	deleterious	0.28	0.55	0.53	disease	0.55	disease	0.46	neutral	0.5	neutral	0	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.74	0.9	1.36	6.62	0.6	P	0.59	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6297	6297	T	G	MI.2715	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	394	132	L	V	Tta/Gta	-13.98	0	0	probably_damaging	0.99	deleterious	0	neutral	1.97	deleterious	-3.99	deleterious	-2.5	high_impact	4.96	0.53	damaging	0.11	damaging	3.37	22.90	deleterious	0.31	0.55	0.7	disease	0.61	disease	0.64	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	3.48	high_impact	0.57	0.9	1.36	6.62	0.6	P	0.66	polymorphism	0.98	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6298	6298	T	C	MI.2716	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	395	132	L	S	tTa/tCa	-4.04	0	0	probably_damaging	1	deleterious	0.01	neutral	1.9	deleterious	-5.74	deleterious	-5.01	high_impact	5.3	0.62	neutral	0.13	damaging	3.69	23.30	deleterious	0.24	0.55	0.9	disease	0.77	disease	0.65	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-0.92	medium_impact	3.8	high_impact	0.57	0.9	1.36	6.62	0.61	P	0.73	polymorphism	0.98	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6298	6298	T	G	MI.2717	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	395	132	L	W	tTa/tGa	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	1.87	deleterious	-7.77	deleterious	-5.01	high_impact	5.3	0.59	damaging	0.13	damaging	3.69	23.30	deleterious	0.15	0.55	0.94	disease	0.67	disease	0.68	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.53	0.9	1.36	6.62	0.57	P	0.92	polymorphism	0.97	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6299	6299	A	T	MI.2718	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	396	132	L	F	ttA/ttT	7.53	1	0	probably_damaging	1	deleterious	0	neutral	1.93	deleterious	-4.62	deleterious	-3.34	high_impact	5.3	0.48	damaging	0.09	damaging	3.52	23.10	deleterious	0.3	0.55	0.54	disease	0.73	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.59	0.9	1.36	6.62	0.69	P	0.87	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6299	6299	A	C	MI.2719	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	396	132	L	F	ttA/ttC	7.53	1	0	probably_damaging	1	deleterious	0	neutral	1.93	deleterious	-4.62	deleterious	-3.34	high_impact	5.3	0.48	damaging	0.09	damaging	3.41	23.00	deleterious	0.3	0.55	0.54	disease	0.73	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.59	0.9	1.36	6.62	0.69	P	0.87	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8653	8653	A	G	MI.272	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	127	43	I	V	Atc/Gtc	-8.89	0	0	benign	0.01	neutral	0.53	neutral	4.41	neutral	0.29	neutral	-0.07	neutral_impact	0.65	0.98	neutral	0.98	neutral	-0.97	0.02	neutral	0.61	0.7	0.39	neutral	0.12	neutral	0.17	neutral	0.3	neutral	4	0.46	neutral	0.76	deleterious	-6	neutral	0.10	neutral	1.14	medium_impact	0.32	medium_impact	-0.54	medium_impact	0.42	0.9	31.42	20.88	0.41	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6300	6300	G	C	MI.2720	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	397	133	A	P	Gca/Cca	0.13	0.98	0	possibly_damaging	0.82	deleterious	0	neutral	2.68	neutral	-2.63	neutral	-2.43	medium_impact	2.79	0.6	damaging	0.32	neutral	3.68	23.30	deleterious	0.17	0.55	0.24	neutral	0.83	disease	0.47	neutral	0.73	disease	5	1	deleterious	0.09	neutral	4	deleterious	0.72	deleterious	-1.38	low_impact	-1.48	low_impact	1.48	medium_impact	0.75	0.9	6.24	14.89	0.47	N	0.85	disease_causing	0.98	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6300	6300	G	T	MI.2721	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	397	133	A	S	Gca/Tca	0.13	0.98	0	benign	0.02	neutral	1	neutral	2.97	neutral	1.13	neutral	0.92	neutral_impact	-2	0.66	neutral	0.61	neutral	-1.00	0.02	neutral	0.36	0.55	0.2	neutral	0.04	neutral	0.1	neutral	0.25	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.12	neutral	0.83	medium_impact	1.86	high_impact	-2.95	low_impact	0.78	0.9	6.24	14.89	0.4	N	0.64	disease_causing	0.84	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6300	6300	G	A	MI.2722	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	397	133	A	T	Gca/Aca	0.13	0.98	0	benign	0.39	deleterious	0.04	neutral	2.79	neutral	-0.2	neutral	-0.94	low_impact	1.04	0.61	neutral	0.35	neutral	2.51	19.52	deleterious	0.41	0.55	0.29	neutral	0.59	disease	0.31	neutral	0.46	neutral	1	0.95	neutral	0.33	neutral	-2	neutral	0.49	deleterious	-0.57	medium_impact	-0.58	medium_impact	-0.14	medium_impact	0.75	0.9	6.24	14.89	0.47	N	0.20	disease_causing	0.93	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6301	6301	C	G	MI.2723	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	398	133	A	G	gCa/gGa	3.6	1	0	benign	0.16	deleterious	0	neutral	2.69	neutral	-2.05	neutral	-1.63	medium_impact	3.13	0.62	neutral	0.49	neutral	2.05	16.52	deleterious	0.29	0.55	0.54	disease	0.54	disease	0.47	neutral	0.5	disease	0	1	deleterious	0.42	neutral	1	deleterious	0.32	neutral	-0.08	medium_impact	-1.48	low_impact	1.79	medium_impact	0.75	0.9	6.24	14.89	0.52	P	0.56	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6301	6301	C	T	MI.2724	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	398	133	A	V	gCa/gTa	3.6	1	0	benign	0.34	deleterious	0	neutral	2.7	neutral	-1.84	deleterious	-2.7	medium_impact	2.24	0.6	neutral	0.35	neutral	2.75	21.10	deleterious	0.29	0.55	0.48	neutral	0.65	disease	0.51	disease	0.55	disease	1	1	deleterious	0.33	neutral	1	deleterious	0.59	deleterious	-0.49	medium_impact	-1.48	low_impact	0.97	medium_impact	0.80	0.9	6.24	14.89	0.44	N	0.75	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6301	6301	C	A	MI.2725	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	398	133	A	E	gCa/gAa	3.6	1	0	possibly_damaging	0.57	deleterious	0	neutral	2.77	neutral	-0.44	neutral	-1.87	medium_impact	3.13	0.61	neutral	0.38	neutral	4.16	23.80	deleterious	0.19	0.55	0.42	neutral	0.8	disease	0.63	disease	0.73	disease	5	1	deleterious	0.22	neutral	4	deleterious	0.67	deleterious	-0.87	medium_impact	-1.48	low_impact	1.79	medium_impact	0.75	0.9	6.24	14.89	0.45	N	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6303	6303	G	C	MI.2726	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	400	134	G	R	Ggg/Cgg	-11.9	0	0	probably_damaging	1	deleterious	0.04	neutral	2.93	neutral	-1.15	neutral	-1.99	medium_impact	2.5	0.58	damaging	0.07	damaging	3.92	23.50	deleterious	0.36	0.55	0.28	neutral	0.8	disease	0.59	disease	0.75	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-0.58	medium_impact	1.21	medium_impact	0.83	0.9	4.09	7.89	0.25	N	0.95	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6303	6303	G	T	MI.2727	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	400	134	G	W	Ggg/Tgg	-11.9	0	0	probably_damaging	1	deleterious	0	neutral	2.9	neutral	-2.22	deleterious	-3.35	medium_impact	3.06	0.64	neutral	0.08	damaging	4.37	24.10	deleterious	0.21	0.55	0.74	disease	0.8	disease	0.55	disease	0.76	disease	5	1	deleterious	0	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	1.73	medium_impact	0.47	0.9	4.09	7.89	0.23	N	0.83	polymorphism	0.94	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6304	6304	G	C	MI.2728	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	401	134	G	A	gGg/gCg	3.6	1	0	probably_damaging	1	neutral	0.14	neutral	3.04	neutral	0.44	neutral	-0.15	neutral_impact	0.11	0.66	neutral	0.3	neutral	1.60	13.84	neutral	0.52	0.6	0.15	neutral	0.36	neutral	0.15	neutral	0.45	neutral	1	1	deleterious	0.07	neutral	-2	neutral	0.68	deleterious	-3.58	low_impact	-0.25	medium_impact	-1	medium_impact	0.57	0.9	4.09	7.89	0.55	P	0.64	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6304	6304	G	A	MI.2729	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	401	134	G	E	gGg/gAg	3.6	1	0	probably_damaging	1	deleterious	0	neutral	2.93	neutral	-1.29	neutral	-1.48	medium_impact	2.5	0.61	neutral	0.09	damaging	3.87	23.50	deleterious	0.41	0.55	0.21	neutral	0.8	disease	0.57	disease	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	1.21	medium_impact	0.62	0.9	4.09	7.89	0.37	N	0.93	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8654	8654	T	G	MI.273	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	128	43	I	S	aTc/aGc	-5.89	0	0	possibly_damaging	0.56	neutral	0.48	neutral	4.44	neutral	0.82	neutral	-2.39	neutral_impact	-0.6	0.81	neutral	0.76	neutral	0.61	8.20	deleterious	0.43	0.65	0.41	neutral	0.28	neutral	0.22	neutral	0.45	neutral	1	0.56	neutral	0.46	neutral	-3	neutral	0.41	neutral	-0.86	medium_impact	0.27	medium_impact	-1.61	low_impact	0.39	0.9	31.42	20.88	0.27	N	0.42	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6304	6304	G	T	MI.2730	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	401	134	G	V	gGg/gTg	3.6	1	0	probably_damaging	1	neutral	0.1	neutral	2.99	neutral	-0.13	deleterious	-2.63	low_impact	1.81	0.57	damaging	0.09	damaging	3.71	23.30	deleterious	0.34	0.55	0.28	neutral	0.74	disease	0.48	neutral	0.55	disease	1	1	deleterious	0.05	neutral	-2	neutral	0.74	deleterious	-3.58	low_impact	-0.34	medium_impact	0.57	medium_impact	0.52	0.9	4.09	7.89	0.33	N	0.93	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6306	6306	A	G	MI.2731	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	403	135	N	D	Aac/Gac	-9.13	0	0	probably_damaging	0.99	neutral	0.08	neutral	2.77	neutral	-0.65	deleterious	-2.69	medium_impact	3.31	0.54	damaging	0.06	damaging	3.79	23.40	deleterious	0.67	0.7	0.3	neutral	0.51	disease	0.35	neutral	0.48	neutral	0	1	deleterious	0.05	neutral	1	deleterious	0.69	deleterious	-2.64	low_impact	-0.4	medium_impact	1.96	medium_impact	0.43	0.9	1.36	6.64	0.33	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6306	6306	A	T	MI.2732	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	403	135	N	Y	Aac/Tac	-9.13	0	0	probably_damaging	1	neutral	0.23	neutral	2.72	neutral	-2.19	deleterious	-4	medium_impact	2.67	0.53	damaging	0.06	damaging	3.65	23.20	deleterious	0.47	0.55	0.62	disease	0.65	disease	0.21	neutral	0.48	neutral	0	1	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-3.58	low_impact	-0.1	medium_impact	1.37	medium_impact	0.39	0.9	1.36	6.64	0.31	N	0.93	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6306	6306	A	C	MI.2733	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	403	135	N	H	Aac/Cac	-9.13	0	0	probably_damaging	1	neutral	0.09	neutral	2.73	neutral	-1.76	deleterious	-2.7	high_impact	3.8	0.59	damaging	0.06	damaging	3.04	22.40	deleterious	0.56	0.6	0.33	neutral	0.5	neutral	0.38	neutral	0.5	neutral	0	1	deleterious	0.05	neutral	2	deleterious	0.71	deleterious	-3.58	low_impact	-0.37	medium_impact	2.41	high_impact	0.38	0.9	1.36	6.64	0.36	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6307	6307	A	G	MI.2734	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	404	135	N	S	aAc/aGc	8.69	1	0	probably_damaging	0.97	neutral	0.15	neutral	2.89	neutral	0.88	neutral	-2.04	low_impact	1.17	0.5	damaging	0.09	damaging	1.86	15.36	deleterious	0.62	0.65	0.26	neutral	0.32	neutral	0.2	neutral	0.45	neutral	1	0.99	deleterious	0.09	neutral	-2	neutral	0.69	deleterious	-2.18	low_impact	-0.23	medium_impact	-0.02	medium_impact	0.23	0.9	1.36	6.64	0.57	P	0.79	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6307	6307	A	T	MI.2735	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	404	135	N	I	aAc/aTc	8.69	1	0	probably_damaging	1	neutral	0.24	neutral	2.75	neutral	-1.04	deleterious	-4.42	low_impact	1.51	0.53	damaging	0.09	damaging	2.75	21.10	deleterious	0.43	0.55	0.27	neutral	0.47	neutral	0.2	neutral	0.46	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.09	medium_impact	0.3	medium_impact	0.31	0.9	1.36	6.64	0.51	P	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6307	6307	A	C	MI.2736	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	404	135	N	T	aAc/aCc	8.69	1	0	probably_damaging	0.99	neutral	0.33	neutral	2.8	neutral	-0.12	deleterious	-2.73	medium_impact	2.54	0.59	damaging	0.1	damaging	3.27	22.80	deleterious	0.52	0.6	0.22	neutral	0.49	neutral	0.31	neutral	0.43	neutral	1	0.99	deleterious	0.17	neutral	1	deleterious	0.69	deleterious	-2.64	low_impact	0.02	medium_impact	1.25	medium_impact	0.46	0.9	1.36	6.64	0.5	P	0.59	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6308	6308	C	A	MI.2737	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	405	135	N	K	aaC/aaA	8.69	1	0	probably_damaging	1	neutral	0.11	neutral	2.82	neutral	0.12	deleterious	-3.14	medium_impact	2.88	0.55	damaging	0.05	damaging	4.32	24.00	deleterious	0.73	0.75	0.25	neutral	0.45	neutral	0.27	neutral	0.45	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.71	deleterious	-3.58	low_impact	-0.31	medium_impact	1.56	medium_impact	0.59	0.9	1.36	6.64	0.54	P	0.92	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6308	6308	C	G	MI.2738	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	405	135	N	K	aaC/aaG	8.69	1	0	probably_damaging	1	neutral	0.11	neutral	2.82	neutral	0.12	deleterious	-3.14	medium_impact	2.88	0.55	damaging	0.05	damaging	3.89	23.50	deleterious	0.73	0.75	0.25	neutral	0.45	neutral	0.27	neutral	0.45	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.71	deleterious	-3.58	low_impact	-0.31	medium_impact	1.56	medium_impact	0.59	0.9	1.36	6.64	0.54	P	0.92	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6309	6309	T	G	MI.2739	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	406	136	Y	D	Tac/Gac	-1.26	0	0	benign	0.01	deleterious	0.02	neutral	2.82	neutral	0.78	neutral	-1.57	neutral_impact	-0.94	0.52	damaging	0.37	neutral	3.52	23.10	deleterious	0.41	0.55	0.2	neutral	0.53	disease	0.39	neutral	0.49	neutral	0	0.98	neutral	0.51	deleterious	-2	neutral	0.15	neutral	1.12	medium_impact	-0.75	medium_impact	-1.97	low_impact	0.37	0.9	14.04	52.37	0.41	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8654	8654	T	C	MI.274	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	128	43	I	T	aTc/aCc	-5.89	0	0	benign	0.28	neutral	0.44	neutral	4.39	neutral	0	neutral	-1.22	neutral_impact	0.31	0.94	neutral	0.98	neutral	-0.30	0.65	neutral	0.4	0.65	0.58	disease	0.22	neutral	0.2	neutral	0.49	neutral	0	0.47	neutral	0.58	deleterious	-6	neutral	0.37	neutral	-0.37	medium_impact	0.23	medium_impact	-0.83	medium_impact	0.39	0.9	31.42	20.88	0.32	N	0.33	polymorphism	1	0.02	rs200811540	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6309	6309	T	A	MI.2740	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	406	136	Y	N	Tac/Aac	-1.26	0	0	benign	0.01	deleterious	0.01	neutral	2.79	neutral	0.48	neutral	-1.37	neutral_impact	0	0.58	damaging	0.56	neutral	3.79	23.40	deleterious	0.46	0.55	0.18	neutral	0.46	neutral	0.31	neutral	0.47	neutral	1	0.99	deleterious	0.5	deleterious	-2	neutral	0.14	neutral	1.12	medium_impact	-0.92	medium_impact	-1.1	low_impact	0.26	0.9	14.04	52.37	0.44	N	0.61	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6309	6309	T	C	MI.2741	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	406	136	Y	H	Tac/Cac	-1.26	0	0	benign	0.03	deleterious	0.01	neutral	2.76	neutral	-0.6	neutral	-1.41	low_impact	0.9	0.59	damaging	0.39	neutral	3.23	22.80	deleterious	0.66	0.7	0.34	neutral	0.29	neutral	0.32	neutral	0.44	neutral	1	0.99	deleterious	0.49	deleterious	-2	neutral	0.18	neutral	0.66	medium_impact	-0.92	medium_impact	-0.27	medium_impact	0.20	0.9	14.04	52.37	0.45	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6310	6310	A	G	MI.2742	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	407	136	Y	C	tAc/tGc	-0.33	0	0	benign	0.04	deleterious	0.01	neutral	2.75	neutral	-2.34	neutral	-0.09	neutral_impact	0.55	0.53	damaging	0.36	neutral	3.26	22.80	deleterious	0.41	0.55	0.47	neutral	0.57	disease	0.34	neutral	0.46	neutral	1	0.99	deleterious	0.49	deleterious	-2	neutral	0.21	neutral	0.54	medium_impact	-0.92	medium_impact	-0.59	medium_impact	0.12	0.9	14.04	52.37	0.44	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6310	6310	A	T	MI.2743	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	407	136	Y	F	tAc/tTc	-0.33	0	0	benign	0	deleterious	0.02	neutral	2.79	neutral	-0.38	neutral	0.66	neutral_impact	-0.8	0.64	neutral	0.69	neutral	1.40	12.81	neutral	0.43	0.55	0.3	neutral	0.33	neutral	0.28	neutral	0.45	neutral	1	0.98	neutral	0.51	deleterious	-2	neutral	0.13	neutral	2.07	high_impact	-0.75	medium_impact	-1.84	low_impact	0.20	0.9	14.04	52.37	0.46	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6310	6310	A	C	MI.2744	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	407	136	Y	S	tAc/tCc	-0.33	0	0	benign	0	deleterious	0.01	neutral	2.85	neutral	1.08	neutral	-0.58	neutral_impact	-1.59	0.54	damaging	0.54	neutral	1.82	15.09	deleterious	0.29	0.55	0.17	neutral	0.36	neutral	0.22	neutral	0.44	neutral	1	0.99	deleterious	0.51	deleterious	-2	neutral	0.13	neutral	2.07	high_impact	-0.92	medium_impact	-2.57	low_impact	0.29	0.9	14.04	52.37	0.48	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6312	6312	T	C	MI.2745	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	409	137	S	P	Tcc/Ccc	-7.28	0	0	possibly_damaging	0.74	deleterious	0.02	neutral	2.94	neutral	-1.57	neutral	-2.01	medium_impact	2.38	0.54	damaging	0.3	neutral	3.85	23.40	deleterious	0.24	0.55	0.52	disease	0.77	disease	0.44	neutral	0.56	disease	1	0.98	deleterious	0.14	neutral	4	deleterious	0.56	deleterious	-1.18	low_impact	-0.75	medium_impact	1.1	medium_impact	0.54	0.9	13.84	61.64	0.31	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6312	6312	T	A	MI.2746	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	409	137	S	T	Tcc/Acc	-7.28	0	0	benign	0.34	neutral	0.05	neutral	2.97	neutral	-0.64	neutral	-1.09	low_impact	1.78	0.69	neutral	0.64	neutral	2.19	17.42	deleterious	0.3	0.55	0.19	neutral	0.34	neutral	0.42	neutral	0.44	neutral	1	0.94	neutral	0.36	neutral	-6	neutral	0.24	neutral	-0.49	medium_impact	-0.52	medium_impact	0.55	medium_impact	0.71	0.9	13.84	61.64	0.5	N	0.08	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6312	6312	T	G	MI.2747	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	409	137	S	A	Tcc/Gcc	-7.28	0	0	benign	0.01	neutral	1	neutral	3.16	neutral	1.61	neutral	1.28	neutral_impact	-0.74	0.74	neutral	0.92	neutral	-0.85	0.03	neutral	0.41	0.55	0.17	neutral	0.04	neutral	0.19	neutral	0.21	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	1.86	high_impact	-1.78	low_impact	0.66	0.9	13.84	61.64	0.42	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6313	6313	C	G	MI.2748	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	410	137	S	C	tCc/tGc	6.14	1	0	probably_damaging	0.92	deleterious	0.01	neutral	2.93	neutral	-2.53	neutral	-1.49	high_impact	3.58	0.48	damaging	0.24	damaging	3.50	23.10	deleterious	0.3	0.55	0.69	disease	0.63	disease	0.45	neutral	0.47	neutral	1	1	deleterious	0.05	neutral	6	deleterious	0.69	deleterious	-1.76	low_impact	-0.92	medium_impact	2.21	high_impact	0.62	0.9	13.84	61.64	0.56	P	0.37	disease_causing	0.84	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6313	6313	C	T	MI.2749	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	410	137	S	F	tCc/tTc	6.14	1	0	possibly_damaging	0.9	neutral	0.16	neutral	3.04	neutral	0.51	neutral	-2.28	neutral_impact	0.66	0.5	damaging	0.24	damaging	2.37	18.61	deleterious	0.24	0.55	0.17	neutral	0.6	disease	0.3	neutral	0.42	neutral	2	0.95	neutral	0.13	neutral	-3	neutral	0.61	deleterious	-1.65	low_impact	-0.21	medium_impact	-0.49	medium_impact	0.31	0.9	13.84	61.64	0.55	P	0.71	disease_causing	0.94	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8654	8654	T	A	MI.275	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	128	43	I	N	aTc/aAc	-5.89	0	0	possibly_damaging	0.85	neutral	0.35	neutral	4.39	neutral	0.02	deleterious	-3.44	neutral_impact	0.66	0.85	neutral	0.44	neutral	3.19	22.70	deleterious	0.42	0.65	0.38	neutral	0.59	disease	0.22	neutral	0.43	neutral	1	0.87	neutral	0.25	neutral	-3	neutral	0.63	deleterious	-1.47	low_impact	0.14	medium_impact	-0.53	medium_impact	0.36	0.9	31.42	20.88	0.31	N	0.46	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6313	6313	C	A	MI.2750	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	410	137	S	Y	tCc/tAc	6.14	1	0	possibly_damaging	0.9	neutral	0.11	neutral	3.05	neutral	0.67	neutral	-2.37	low_impact	0.93	0.51	damaging	0.28	neutral	2.07	16.65	deleterious	0.29	0.55	0.31	neutral	0.56	disease	0.27	neutral	0.44	neutral	1	0.96	neutral	0.11	neutral	-3	neutral	0.65	deleterious	-1.65	low_impact	-0.31	medium_impact	-0.24	medium_impact	0.62	0.9	13.84	61.64	0.57	P	0.75	disease_causing	0.9	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6315	6315	C	G	MI.2751	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	412	138	H	D	Cac/Gac	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-1.91	deleterious	-7.52	high_impact	4.41	0.62	neutral	0.09	damaging	3.83	23.40	deleterious	0.34	0.55	0.41	neutral	0.82	disease	0.82	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.46	0.9	2.73	6.86	0.48	N	0.97	polymorphism	0.86	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6315	6315	C	A	MI.2752	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	412	138	H	N	Cac/Aac	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-1.64	deleterious	-5.85	high_impact	4.13	0.57	damaging	0.09	damaging	3.90	23.50	deleterious	0.64	0.7	0.41	neutral	0.81	disease	0.79	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.42	0.9	2.73	6.86	0.4	N	0.86	polymorphism	0.95	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6315	6315	C	T	MI.2753	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	412	138	H	Y	Cac/Tac	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-2.71	deleterious	-4.87	high_impact	3.52	0.62	neutral	0.08	damaging	3.72	23.30	deleterious	0.61	0.65	0.42	neutral	0.81	disease	0.79	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.15	high_impact	0.25	0.9	2.73	6.86	0.37	N	0.72	polymorphism	0.94	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6316	6316	A	T	MI.2754	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	413	138	H	L	cAc/cTc	5.45	1	0	probably_damaging	1	deleterious	0.03	neutral	2.8	neutral	-2.59	deleterious	-9.13	high_impact	3.86	0.63	neutral	0.08	damaging	4.33	24.00	deleterious	0.32	0.55	0.41	neutral	0.88	disease	0.78	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-0.65	medium_impact	2.47	high_impact	0.32	0.9	2.73	6.86	0.57	P	0.92	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6316	6316	A	G	MI.2755	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	413	138	H	R	cAc/cGc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-2.48	deleterious	-6.68	high_impact	5.11	0.55	damaging	0.12	damaging	3.48	23.10	deleterious	0.57	0.6	0.39	neutral	0.83	disease	0.78	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.30	0.9	2.73	6.86	0.66	P	0.85	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6316	6316	A	C	MI.2756	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	413	138	H	P	cAc/cCc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-2.41	deleterious	-8.35	high_impact	4.75	0.55	damaging	0.1	damaging	3.69	23.30	deleterious	0.28	0.55	0.59	disease	0.85	disease	0.78	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.31	0.9	2.73	6.86	0.65	P	0.90	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6317	6317	C	G	MI.2757	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	414	138	H	Q	caC/caG	8.69	1	0	probably_damaging	1	neutral	0.06	neutral	2.82	neutral	-1.94	deleterious	-6.66	medium_impact	2.88	0.59	damaging	0.12	damaging	3.55	23.10	deleterious	0.65	0.7	0.16	neutral	0.74	disease	0.74	disease	0.56	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.71	deleterious	-3.58	low_impact	-0.47	medium_impact	1.56	medium_impact	0.35	0.9	2.73	6.86	0.43	N	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6317	6317	C	A	MI.2758	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	414	138	H	Q	caC/caA	8.69	1	0	probably_damaging	1	neutral	0.06	neutral	2.82	neutral	-1.94	deleterious	-6.66	medium_impact	2.88	0.59	damaging	0.12	damaging	3.83	23.40	deleterious	0.65	0.7	0.16	neutral	0.74	disease	0.74	disease	0.56	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.71	deleterious	-3.58	low_impact	-0.47	medium_impact	1.56	medium_impact	0.35	0.9	2.73	6.86	0.44	N	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6318	6318	C	T	MI.2759	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	415	139	P	S	Cct/Tct	-1.95	0	0	possibly_damaging	0.57	neutral	0.74	neutral	3.04	neutral	-1.51	neutral	2.12	neutral_impact	-1.43	0.68	neutral	0.82	neutral	1.37	12.62	neutral	0.33	0.55	0.19	neutral	0.08	neutral	0.16	neutral	0.24	neutral	5	0.48	neutral	0.59	deleterious	-3	neutral	0.34	neutral	-0.87	medium_impact	0.45	medium_impact	-2.42	low_impact	0.27	0.9	13.45	64.38	0.36	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8655	8655	C	G	MI.276	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	129	43	I	M	atC/atG	-0.1	0	0	possibly_damaging	0.74	neutral	0.23	neutral	4.37	neutral	-0.67	neutral	-1.06	low_impact	1.2	0.91	neutral	0.73	neutral	1.73	14.55	neutral	0.56	0.65	0.73	disease	0.23	neutral	0.16	neutral	0.55	disease	1	0.84	neutral	0.25	neutral	-3	neutral	0.56	deleterious	-1.19	low_impact	-0.01	medium_impact	-0.07	medium_impact	0.68	0.9	31.42	20.88	0.52	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6318	6318	C	A	MI.2760	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	415	139	P	T	Cct/Act	-1.95	0	0	possibly_damaging	0.57	deleterious	0.02	neutral	2.92	neutral	-1.94	neutral	0.83	low_impact	1.7	0.64	neutral	0.78	neutral	3.71	23.30	deleterious	0.26	0.55	0.23	neutral	0.23	neutral	0.27	neutral	0.43	neutral	1	0.98	neutral	0.23	neutral	1	deleterious	0.35	neutral	-0.87	medium_impact	-0.75	medium_impact	0.47	medium_impact	0.58	0.9	13.45	64.38	0.51	P	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6318	6318	C	G	MI.2761	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	415	139	P	A	Cct/Gct	-1.95	0	0	benign	0.04	neutral	1	neutral	2.95	neutral	-1.65	neutral	2.03	neutral_impact	-0.34	0.76	neutral	0.99	neutral	0.26	5.28	deleterious	0.28	0.55	0.17	neutral	0.08	neutral	0.27	neutral	0.28	neutral	4	0.04	neutral	0.98	deleterious	-6	neutral	0.09	neutral	0.54	medium_impact	1.86	high_impact	-1.41	low_impact	0.68	0.9	13.45	64.38	0.32	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6319	6319	C	T	MI.2762	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	416	139	P	L	cCt/cTt	5.22	1	0	possibly_damaging	0.57	neutral	0.07	neutral	3.04	neutral	-2.17	neutral	-0.84	low_impact	1.67	0.63	neutral	0.57	neutral	4.22	23.90	deleterious	0.29	0.55	0.26	neutral	0.39	neutral	0.5	neutral	0.43	neutral	1	0.93	neutral	0.25	neutral	-3	neutral	0.38	neutral	-0.87	medium_impact	-0.43	medium_impact	0.44	medium_impact	0.68	0.9	13.45	64.38	0.63	P	0.58	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6319	6319	C	A	MI.2763	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	416	139	P	H	cCt/cAt	5.22	1	0	probably_damaging	0.97	deleterious	0	neutral	2.88	deleterious	-3.28	neutral	-0.52	low_impact	1.76	0.61	neutral	0.48	neutral	3.89	23.50	deleterious	0.31	0.55	0.43	neutral	0.35	neutral	0.58	disease	0.48	neutral	1	1	deleterious	0.02	neutral	2	deleterious	0.65	deleterious	-2.18	low_impact	-1.48	low_impact	0.53	medium_impact	0.63	0.9	13.45	64.38	0.54	P	0.63	polymorphism	0.87	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6319	6319	C	G	MI.2764	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	416	139	P	R	cCt/cGt	5.22	1	0	probably_damaging	0.91	deleterious	0	neutral	2.89	neutral	-2.69	neutral	-0.22	medium_impact	2.77	0.56	damaging	0.48	neutral	3.54	23.10	deleterious	0.3	0.55	0.28	neutral	0.55	disease	0.64	disease	0.69	disease	4	1	deleterious	0.05	neutral	5	deleterious	0.60	deleterious	-1.7	low_impact	-1.48	low_impact	1.46	medium_impact	0.63	0.9	13.45	64.38	0.49	P	0.58	polymorphism	0.78	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6321	6321	G	C	MI.2765	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	418	140	G	R	Gga/Cga	-5.66	0	0	probably_damaging	1	deleterious	0.02	neutral	2.66	deleterious	-3.23	deleterious	-6.23	high_impact	5.1	0.44	damaging	0.02	damaging	3.90	23.50	deleterious	0.26	0.55	0.57	disease	0.86	disease	0.76	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-0.75	medium_impact	3.61	high_impact	0.80	0.9	3.51	6.71	0.55	P	0.95	polymorphism	0.78	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6321	6321	G	T	MI.2766	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	418	140	G	W	Gga/Tga	-5.66	0	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-4	deleterious	-6.42	high_impact	5.1	0.4	damaging	0.03	damaging	4.37	24.10	deleterious	0.19	0.55	0.93	disease	0.86	disease	0.76	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.61	high_impact	0.42	0.9	3.51	6.71	0.58	P	0.83	polymorphism	0.68	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6322	6322	G	C	MI.2767	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	419	140	G	A	gGa/gCa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.9	deleterious	-4.71	high_impact	4.41	0.57	damaging	0.05	damaging	3.02	22.30	deleterious	0.33	0.55	0.52	disease	0.66	disease	0.66	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.72	0.9	3.51	6.71	0.5	P	0.64	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6322	6322	G	T	MI.2768	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	419	140	G	V	gGa/gTa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.09	deleterious	-7.14	high_impact	5.1	0.48	damaging	0.03	damaging	3.67	23.30	deleterious	0.23	0.55	0.68	disease	0.86	disease	0.72	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.61	high_impact	0.55	0.9	3.51	6.71	0.66	P	0.93	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6322	6322	G	A	MI.2769	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	419	140	G	E	gGa/gAa	7.3	1	0	probably_damaging	1	neutral	0.05	neutral	2.76	neutral	-1.55	deleterious	-6.15	high_impact	4.75	0.39	damaging	0.03	damaging	3.75	23.30	deleterious	0.38	0.55	0.45	neutral	0.85	disease	0.74	disease	0.7	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.82	deleterious	-3.58	low_impact	-0.52	medium_impact	3.29	high_impact	0.61	0.9	3.51	6.71	0.74	P	0.93	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8655	8655	C	A	MI.277	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	129	43	I	M	atC/atA	-0.1	0	0	possibly_damaging	0.74	neutral	0.23	neutral	4.37	neutral	-0.67	neutral	-1.06	low_impact	1.2	0.91	neutral	0.73	neutral	2.15	17.16	deleterious	0.56	0.65	0.73	disease	0.23	neutral	0.16	neutral	0.55	disease	1	0.84	neutral	0.25	neutral	-3	neutral	0.56	deleterious	-1.19	low_impact	-0.01	medium_impact	-0.07	medium_impact	0.68	0.9	31.42	20.88	0.52	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6324	6324	G	C	MI.2770	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	421	141	A	P	Gcc/Ccc	-3.34	0	0	benign	0.06	neutral	0.39	neutral	2.99	neutral	-0.11	neutral	-1.16	neutral_impact	-0.36	0.7	neutral	0.61	neutral	2.09	16.80	deleterious	0.18	0.55	0.24	neutral	0.4	neutral	0.14	neutral	0.45	neutral	1	0.57	neutral	0.67	deleterious	-6	neutral	0.18	neutral	0.37	medium_impact	0.09	medium_impact	-1.43	low_impact	0.66	0.9	7.6	10.17	0.48	N	0.85	disease_causing	0.91	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6324	6324	G	A	MI.2771	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	421	141	A	T	Gcc/Acc	-3.34	0	0	possibly_damaging	0.63	deleterious	0.04	neutral	2.96	neutral	-0.56	neutral	-1.23	medium_impact	2.09	0.65	neutral	0.48	neutral	4.09	23.70	deleterious	0.34	0.55	0.27	neutral	0.53	disease	0.35	neutral	0.4	neutral	2	0.96	neutral	0.21	neutral	4	deleterious	0.52	deleterious	-0.97	medium_impact	-0.58	medium_impact	0.83	medium_impact	0.68	0.9	7.6	10.17	0.44	N	0.20	disease_causing	0.75	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6324	6324	G	T	MI.2772	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	421	141	A	S	Gcc/Tcc	-3.34	0	0	possibly_damaging	0.5	neutral	0.51	neutral	2.95	neutral	-0.69	neutral	-0.28	neutral_impact	0.36	0.66	neutral	0.61	neutral	2.24	17.79	deleterious	0.24	0.55	0.34	neutral	0.34	neutral	0.18	neutral	0.47	neutral	1	0.49	neutral	0.51	deleterious	-3	neutral	0.36	neutral	-0.76	medium_impact	0.2	medium_impact	-0.77	medium_impact	0.68	0.9	7.6	10.17	0.44	N	0.64	disease_causing	0.57	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6325	6325	C	G	MI.2773	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	422	141	A	G	gCc/gGc	4.06	1	0	benign	0.34	neutral	0.3	neutral	2.93	neutral	-1.27	neutral	-1.2	neutral_impact	0.62	0.65	neutral	0.61	neutral	2.43	19.00	deleterious	0.2	0.55	0.24	neutral	0.36	neutral	0.17	neutral	0.45	neutral	1	0.64	neutral	0.48	deleterious	-6	neutral	0.27	neutral	-0.49	medium_impact	-0.01	medium_impact	-0.53	medium_impact	0.59	0.9	7.6	10.17	0.57	P	0.56	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6325	6325	C	T	MI.2774	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	422	141	A	V	gCc/gTc	4.06	1	0	possibly_damaging	0.66	deleterious	0.02	neutral	3.06	neutral	0.58	neutral	-1.86	low_impact	0.92	0.64	neutral	0.4	neutral	3.29	22.80	deleterious	0.26	0.55	0.21	neutral	0.58	disease	0.23	neutral	0.27	neutral	5	0.98	deleterious	0.18	neutral	1	deleterious	0.58	deleterious	-1.03	low_impact	-0.75	medium_impact	-0.25	medium_impact	0.57	0.9	7.6	10.17	0.53	P	0.75	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6325	6325	C	A	MI.2775	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	422	141	A	D	gCc/gAc	4.06	1	0	probably_damaging	0.98	deleterious	0.01	neutral	2.91	neutral	-2.08	neutral	-2.23	high_impact	3.67	0.61	neutral	0.35	neutral	4.58	24.40	deleterious	0.2	0.55	0.56	disease	0.83	disease	0.48	neutral	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-0.92	medium_impact	2.29	high_impact	0.51	0.9	7.6	10.17	0.47	N	0.89	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6327	6327	T	G	MI.2776	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	424	142	S	A	Tcc/Gcc	-8.2	0	0	probably_damaging	0.99	deleterious	0.04	neutral	2.94	neutral	-0.53	neutral	-2.06	low_impact	1.86	0.47	damaging	0.22	damaging	2.49	19.43	deleterious	0.36	0.55	0.25	neutral	0.32	neutral	0.56	disease	0.4	neutral	2	1	deleterious	0.03	neutral	2	deleterious	0.69	deleterious	-2.64	low_impact	-0.58	medium_impact	0.62	medium_impact	0.71	0.9	1.95	6.61	0.42	N	0.35	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6327	6327	T	A	MI.2777	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	424	142	S	T	Tcc/Acc	-8.2	0	0	probably_damaging	0.99	deleterious	0.03	neutral	2.85	neutral	-2.05	neutral	-2.33	high_impact	3.7	0.41	damaging	0.11	damaging	3.76	23.30	deleterious	0.26	0.55	0.57	disease	0.69	disease	0.77	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-0.65	medium_impact	2.32	high_impact	0.75	0.9	1.95	6.61	0.47	N	0.43	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6327	6327	T	C	MI.2778	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	424	142	S	P	Tcc/Ccc	-8.2	0	0	probably_damaging	1	deleterious	0	neutral	2.9	neutral	-1.05	deleterious	-3.9	high_impact	4.18	0.3	damaging	0.1	damaging	3.91	23.50	deleterious	0.23	0.55	0.76	disease	0.83	disease	0.85	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.76	high_impact	0.57	0.9	1.95	6.61	0.62	P	0.91	polymorphism	0.98	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6328	6328	C	T	MI.2779	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	425	142	S	F	tCc/tTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	-1.84	deleterious	-4.74	high_impact	4.99	0.23	damaging	0.05	damaging	4.19	23.90	deleterious	0.17	0.55	0.81	disease	0.88	disease	0.78	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.34	0.9	1.95	6.61	0.9	P	0.98	disease_causing_automatic	1	0.18	rs267606883	Pathogenic	Cytochrome_c_oxidase_i_deficiency	24710	MedGen:CN069330	.	.	.	.	C6328T	EXIT (Exercise Intolerance)	+	-	Reported	2	P	P	P	damaging
chrM	8656	8656	A	G	MI.278	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	130	44	T	A	Acc/Gcc	-10.51	0	0	benign	0	neutral	0.48	neutral	4.36	neutral	-0.45	neutral	-2.25	low_impact	1.29	0.92	neutral	0.94	neutral	0.13	3.93	deleterious	0.67	0.75	0.41	neutral	0.37	neutral	0.3	neutral	0.47	neutral	1	0.51	neutral	0.74	deleterious	-6	neutral	0.17	neutral	2.09	high_impact	0.27	medium_impact	0.01	medium_impact	0.63	0.9	21.24	19.09	0.41	N	0.24	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6328	6328	C	G	MI.2780	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	425	142	S	C	tCc/tGc	7.53	1	0	probably_damaging	1	deleterious	0.03	neutral	2.82	deleterious	-3.41	deleterious	-3.63	medium_impact	2.73	0.37	damaging	0.09	damaging	3.47	23.00	deleterious	0.25	0.55	0.83	disease	0.78	disease	0.7	disease	0.59	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-3.58	low_impact	-0.65	medium_impact	1.42	medium_impact	0.62	0.9	1.95	6.61	0.63	P	0.85	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6328	6328	C	A	MI.2781	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	425	142	S	Y	tCc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.9	neutral	-1.08	deleterious	-4.73	high_impact	4.64	0.39	damaging	0.08	damaging	3.99	23.60	deleterious	0.19	0.55	0.83	disease	0.86	disease	0.78	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.19	high_impact	0.64	0.9	1.95	6.61	0.76	P	0.92	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6330	6330	G	C	MI.2782	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	427	143	V	L	Gta/Cta	-11.44	0	0	probably_damaging	0.97	neutral	0.05	neutral	2.8	neutral	-0.8	neutral	-2.2	high_impact	3.57	0.62	neutral	0.13	damaging	3.52	23.10	deleterious	0.42	0.55	0.51	disease	0.75	disease	0.51	disease	0.55	disease	1	0.99	deleterious	0.04	neutral	2	deleterious	0.78	deleterious	-2.18	low_impact	-0.52	medium_impact	2.2	high_impact	0.87	0.9	4.29	7.21	0.31	N	0.55	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6330	6330	G	T	MI.2783	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	427	143	V	L	Gta/Tta	-11.44	0	0	probably_damaging	0.97	neutral	0.05	neutral	2.8	neutral	-0.8	neutral	-2.2	high_impact	3.57	0.62	neutral	0.13	damaging	3.63	23.20	deleterious	0.42	0.55	0.51	disease	0.75	disease	0.51	disease	0.55	disease	1	0.99	deleterious	0.04	neutral	2	deleterious	0.78	deleterious	-2.18	low_impact	-0.52	medium_impact	2.2	high_impact	0.87	0.9	4.29	7.21	0.31	N	0.55	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6330	6330	G	A	MI.2784	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	427	143	V	M	Gta/Ata	-11.44	0	0	probably_damaging	1	neutral	0.05	neutral	2.7	neutral	-1.55	neutral	-2.11	medium_impact	2.1	0.56	damaging	0.18	damaging	3.63	23.20	deleterious	0.39	0.55	0.68	disease	0.64	disease	0.3	neutral	0.22	neutral	6	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.52	medium_impact	0.84	medium_impact	0.80	0.9	4.29	7.21	0.33	N	0.82	polymorphism	0.98	0.05	.	.	.	.	.	.	COSM1145864	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6331	6331	T	A	MI.2785	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	428	143	V	E	gTa/gAa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.67	deleterious	-4.89	high_impact	5.07	0.61	neutral	0.16	damaging	4.57	24.40	deleterious	0.12	0.55	0.39	neutral	0.87	disease	0.8	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.58	high_impact	0.55	0.9	4.29	7.21	0.71	P	0.84	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6331	6331	T	G	MI.2786	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	428	143	V	G	gTa/gGa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.19	deleterious	-5.74	medium_impact	3.34	0.6	damaging	0.17	damaging	3.75	23.30	deleterious	0.16	0.55	0.49	neutral	0.79	disease	0.69	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	1.99	medium_impact	0.58	0.9	4.29	7.21	0.45	N	0.71	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6331	6331	T	C	MI.2787	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	428	143	V	A	gTa/gCa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-1.76	deleterious	-3.26	medium_impact	3.48	0.67	neutral	0.16	damaging	3.50	23.10	deleterious	0.38	0.55	0.44	neutral	0.62	disease	0.67	disease	0.65	disease	3	1	deleterious	0	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.11	high_impact	0.43	0.9	4.29	7.21	0.53	P	0.47	disease_causing	1	0.11	.	.	.	.	.	.	COSM6716193	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6333	6333	G	C	MI.2788	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	430	144	D	H	Gac/Cac	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.37	deleterious	-4.92	deleterious	-5.88	high_impact	4.91	0.45	damaging	0.07	damaging	3.54	23.10	deleterious	0.27	0.55	0.72	disease	0.86	disease	0.81	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.64	0.9	3.9	7.8	0.6	P	0.97	disease_causing	0.9	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6333	6333	G	A	MI.2789	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	430	144	D	N	Gac/Aac	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.1	deleterious	-4.2	high_impact	3.52	0.4	damaging	0.1	damaging	4.13	23.80	deleterious	0.51	0.6	0.45	neutral	0.8	disease	0.64	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.15	high_impact	0.86	0.9	3.9	7.8	0.42	N	0.89	disease_causing	0.63	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8656	8656	A	C	MI.279	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	130	44	T	P	Acc/Ccc	-10.51	0	0	benign	0.35	neutral	0.09	neutral	4.3	neutral	-2.61	deleterious	-3.67	medium_impact	3.5	0.72	neutral	0.44	neutral	1.63	14.02	neutral	0.13	0.65	0.76	disease	0.87	disease	0.71	disease	0.79	disease	6	0.89	neutral	0.37	neutral	-3	neutral	0.49	deleterious	-0.5	medium_impact	-0.28	medium_impact	1.9	medium_impact	0.70	0.9	21.24	19.09	0.37	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6333	6333	G	T	MI.2790	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	430	144	D	Y	Gac/Tac	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.36	deleterious	-5.62	deleterious	-7.56	high_impact	4.45	0.48	damaging	0.06	damaging	3.84	23.40	deleterious	0.2	0.55	0.74	disease	0.93	disease	0.77	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.52	0.9	3.9	7.8	0.42	N	0.94	disease_causing	0.95	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6334	6334	A	G	MI.2791	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	431	144	D	G	gAc/gGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.44	neutral	-2.98	deleterious	-5.89	high_impact	3.87	0.46	damaging	0.08	damaging	3.86	23.50	deleterious	0.26	0.55	0.67	disease	0.85	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.47	high_impact	0.59	0.9	3.9	7.8	0.55	P	0.85	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6334	6334	A	T	MI.2792	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	431	144	D	V	gAc/gTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.36	deleterious	-5.25	deleterious	-7.57	high_impact	4.45	0.47	damaging	0.07	damaging	3.64	23.20	deleterious	0.19	0.55	0.51	disease	0.91	disease	0.74	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.40	0.9	3.9	7.8	0.5	P	0.93	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6334	6334	A	C	MI.2793	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	431	144	D	A	gAc/gCc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-3.18	deleterious	-6.73	high_impact	4.36	0.58	damaging	0.09	damaging	3.55	23.10	deleterious	0.24	0.55	0.49	neutral	0.8	disease	0.74	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.93	high_impact	0.66	0.9	3.9	7.8	0.51	P	0.85	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6335	6335	C	G	MI.2794	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	432	144	D	E	gaC/gaG	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.44	deleterious	-3.08	deleterious	-3.36	high_impact	3.73	0.44	damaging	0.07	damaging	3.84	23.40	deleterious	0.44	0.55	0.48	neutral	0.79	disease	0.67	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.35	high_impact	0.72	0.9	3.9	7.8	0.6	P	0.65	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6335	6335	C	A	MI.2795	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	432	144	D	E	gaC/gaA	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.44	deleterious	-3.08	deleterious	-3.36	high_impact	3.73	0.44	damaging	0.07	damaging	4.18	23.80	deleterious	0.44	0.55	0.48	neutral	0.79	disease	0.67	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.35	high_impact	0.72	0.9	3.9	7.8	0.61	P	0.65	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6336	6336	C	G	MI.2796	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	433	145	L	V	Cta/Gta	-2.88	0	0	benign	0.38	deleterious	0	neutral	2.63	neutral	-1.47	neutral	-2.02	high_impact	3.51	0.48	damaging	0.1	damaging	3.33	22.90	deleterious	0.29	0.55	0.35	neutral	0.62	disease	0.39	neutral	0.46	neutral	1	1	deleterious	0.31	neutral	2	deleterious	0.36	neutral	-0.56	medium_impact	-1.48	low_impact	2.14	high_impact	0.70	0.9	3.31	8.22	0.38	N	0.66	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6336	6336	C	A	MI.2797	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	433	145	L	M	Cta/Ata	-2.88	0	0	benign	0.38	neutral	0.11	neutral	2.6	neutral	-1.97	neutral	-1.04	low_impact	1.66	0.52	damaging	0.24	damaging	2.69	20.80	deleterious	0.27	0.55	0.45	neutral	0.31	neutral	0.19	neutral	0.46	neutral	1	0.87	neutral	0.37	neutral	-6	neutral	0.30	neutral	-0.56	medium_impact	-0.31	medium_impact	0.43	medium_impact	0.70	0.9	3.31	8.22	0.5	N	0.59	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6337	6337	T	G	MI.2798	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	434	145	L	R	cTa/cGa	-2.19	0	0	probably_damaging	0.99	deleterious	0	neutral	2.53	deleterious	-4.21	deleterious	-4.41	high_impact	4.96	0.5	damaging	0.08	damaging	4.10	23.70	deleterious	0.08	0.55	0.72	disease	0.87	disease	0.67	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.64	low_impact	-1.48	low_impact	3.48	high_impact	0.60	0.9	3.31	8.22	0.6	P	0.90	polymorphism	0.98	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6337	6337	T	A	MI.2799	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	434	145	L	Q	cTa/cAa	-2.19	0	0	probably_damaging	0.99	deleterious	0	neutral	2.51	deleterious	-3.68	deleterious	-4.33	high_impact	4.96	0.51	damaging	0.11	damaging	4.04	23.70	deleterious	0.11	0.55	0.73	disease	0.8	disease	0.54	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	3.48	high_impact	0.70	0.9	3.31	8.22	0.61	P	0.82	polymorphism	0.98	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8538	8538	T	A	MI.28	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	12	4	N	K	aaT/aaA	1.75	0.93	0	benign	0.07	deleterious	0	neutral	4.49	neutral	-0.72	deleterious	-3.89	medium_impact	2.85	0.87	neutral	0.35	neutral	4.65	24.50	deleterious	0.63	0.7	0.6	disease	0.52	disease	0.6	disease	0.69	disease	4	1	deleterious	0.47	neutral	1	deleterious	0.33	neutral	0.31	medium_impact	-1.4	low_impact	1.35	medium_impact	0.28	0.9	41.59	7.51	0.47	N	0.94	disease_causing	0.69	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8656	8656	A	T	MI.280	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	130	44	T	S	Acc/Tcc	-10.51	0	0	benign	0.09	neutral	0.9	neutral	4.5	neutral	0.99	neutral	-0.95	neutral_impact	0.43	0.86	neutral	0.91	neutral	-0.67	0.08	neutral	0.46	0.65	0.36	neutral	0.26	neutral	0.23	neutral	0.45	neutral	1	0.03	neutral	0.91	deleterious	-6	neutral	0.18	neutral	0.2	medium_impact	0.83	medium_impact	-0.73	medium_impact	0.80	0.9	21.24	19.09	0.33	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6337	6337	T	C	MI.2800	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	434	145	L	P	cTa/cCa	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.49	deleterious	-5.22	high_impact	4.41	0.43	damaging	0.09	damaging	3.84	23.40	deleterious	0.11	0.55	0.79	disease	0.82	disease	0.67	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.50	0.9	3.31	8.22	0.42	N	0.83	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6339	6339	A	T	MI.2801	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	436	146	T	S	Acc/Tcc	-1.26	0	0	benign	0.24	neutral	0.12	neutral	2.78	neutral	-0.51	neutral	0.02	neutral_impact	0.76	0.7	neutral	0.68	neutral	0.19	4.54	deleterious	0.47	0.55	0.36	neutral	0.35	neutral	0.16	neutral	0.47	neutral	1	0.86	neutral	0.44	neutral	-6	neutral	0.28	neutral	-0.29	medium_impact	-0.29	medium_impact	-0.4	medium_impact	0.78	0.9	16.76	29.59	0.59	P	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6339	6339	A	G	MI.2802	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	436	146	T	A	Acc/Gcc	-1.26	0	0	benign	0.14	neutral	1	neutral	2.89	neutral	1.07	neutral	1.34	neutral_impact	-0.56	0.77	neutral	0.87	neutral	-1.23	0.01	neutral	0.5	0.6	0.19	neutral	0.06	neutral	0.16	neutral	0.24	neutral	5	0.14	neutral	0.93	deleterious	-6	neutral	0.17	neutral	-0.01	medium_impact	1.86	high_impact	-1.62	low_impact	0.44	0.9	16.76	29.59	0.36	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6339	6339	A	C	MI.2803	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	436	146	T	P	Acc/Ccc	-1.26	0	0	possibly_damaging	0.77	deleterious	0.02	neutral	2.75	neutral	-1.7	neutral	-1.89	high_impact	3.83	0.63	neutral	0.35	neutral	3.06	22.40	deleterious	0.13	0.55	0.59	disease	0.81	disease	0.58	disease	0.74	disease	5	0.99	deleterious	0.13	neutral	5	deleterious	0.73	deleterious	-1.25	low_impact	-0.75	medium_impact	2.44	high_impact	0.64	0.9	16.76	29.59	0.4	N	0.67	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6340	6340	C	G	MI.2804	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	437	146	T	S	aCc/aGc	0.82	0.01	0	benign	0.24	neutral	0.12	neutral	2.78	neutral	-0.51	neutral	0.02	neutral_impact	0.76	0.7	neutral	0.68	neutral	0.37	6.35	deleterious	0.47	0.55	0.36	neutral	0.35	neutral	0.16	neutral	0.47	neutral	1	0.86	neutral	0.44	neutral	-6	neutral	0.28	neutral	-0.29	medium_impact	-0.29	medium_impact	-0.4	medium_impact	0.78	0.9	16.76	29.59	0.59	P	0.15	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6340	6340	C	T	MI.2805	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	437	146	T	I	aCc/aTc	0.82	0.01	0	benign	0.18	deleterious	0	neutral	2.84	neutral	0.56	neutral	-1.85	medium_impact	2.29	0.74	neutral	0.56	neutral	1.90	15.59	deleterious	0.27	0.55	0.21	neutral	0.68	disease	0.43	neutral	0.5	disease	0	1	deleterious	0.41	neutral	1	deleterious	0.18	neutral	-0.14	medium_impact	-1.48	low_impact	1.02	medium_impact	0.71	0.9	16.76	29.59	0.51	N	0.47	polymorphism	1	0.04	.	.	.	.	.	.	.	.	0.45	C6340T	Prostate Cancer	+	-	Reported	2	.	P	P	damaging
chrM	6340	6340	C	A	MI.2806	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	437	146	T	N	aCc/aAc	0.82	0.01	0	possibly_damaging	0.83	deleterious	0.01	neutral	2.74	neutral	-2.1	neutral	-2.1	medium_impact	3.48	0.63	neutral	0.47	neutral	3.43	23.00	deleterious	0.32	0.55	0.54	disease	0.68	disease	0.45	neutral	0.49	neutral	0	0.99	deleterious	0.09	neutral	4	deleterious	0.69	deleterious	-1.4	low_impact	-0.92	medium_impact	2.11	high_impact	0.76	0.9	16.76	29.59	0.39	N	0.53	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6342	6342	A	C	MI.2807	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	439	147	I	L	Atc/Ctc	-14.22	0	0	benign	0.18	deleterious	0	neutral	2.74	neutral	0.18	neutral	-1.74	high_impact	3.7	0.62	neutral	0.13	damaging	3.72	23.30	deleterious	0.34	0.55	0.3	neutral	0.58	disease	0.57	disease	0.62	disease	2	1	deleterious	0.41	neutral	2	deleterious	0.22	neutral	-0.14	medium_impact	-1.48	low_impact	2.32	high_impact	0.75	0.9	5.46	8.09	0.37	N	0.61	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6342	6342	A	T	MI.2808	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	439	147	I	F	Atc/Ttc	-14.22	0	0	possibly_damaging	0.8	deleterious	0	neutral	2.63	neutral	-2.64	deleterious	-3.47	high_impact	4.45	0.53	damaging	0.1	damaging	3.78	23.40	deleterious	0.23	0.55	0.72	disease	0.77	disease	0.7	disease	0.68	disease	4	1	deleterious	0.1	neutral	5	deleterious	0.73	deleterious	-1.32	low_impact	-1.48	low_impact	3.01	high_impact	0.83	0.9	5.46	8.09	0.4	N	0.85	polymorphism	0.58	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6342	6342	A	G	MI.2809	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	439	147	I	V	Atc/Gtc	-14.22	0	0	benign	0.1	deleterious	0.04	neutral	2.68	neutral	-0.79	neutral	-0.87	high_impact	3.52	0.6	neutral	0.15	damaging	2.96	22.10	deleterious	0.48	0.55	0.19	neutral	0.44	neutral	0.59	disease	0.43	neutral	1	0.96	neutral	0.47	deleterious	2	deleterious	0.17	neutral	0.14	medium_impact	-0.58	medium_impact	2.15	high_impact	0.66	0.9	5.46	8.09	0.41	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8657	8657	C	T	MI.281	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	131	44	T	I	aCc/aTc	-3.11	0	0	benign	0	neutral	0.61	neutral	4.41	neutral	0.27	deleterious	-3.54	low_impact	1.31	0.92	neutral	0.86	neutral	1.86	15.34	deleterious	0.38	0.65	0.49	neutral	0.64	disease	0.35	neutral	0.5	neutral	0	0.38	neutral	0.81	deleterious	-6	neutral	0.21	neutral	2.09	high_impact	0.4	medium_impact	0.03	medium_impact	0.76	0.9	21.24	19.09	0.25	N	0.14	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6343	6343	T	C	MI.2810	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	440	147	I	T	aTc/aCc	6.84	1	0	probably_damaging	0.9	deleterious	0	neutral	2.62	neutral	-2.16	deleterious	-4.34	high_impact	4.36	0.54	damaging	0.17	damaging	3.29	22.80	deleterious	0.28	0.55	0.48	neutral	0.69	disease	0.65	disease	0.65	disease	3	1	deleterious	0.05	neutral	6	deleterious	0.60	deleterious	-1.65	low_impact	-1.48	low_impact	2.93	high_impact	0.70	0.9	5.46	8.09	0.5	P	0.76	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6343	6343	T	A	MI.2811	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	440	147	I	N	aTc/aAc	6.84	1	0	probably_damaging	0.94	deleterious	0	neutral	2.59	deleterious	-3.99	deleterious	-6.08	high_impact	5.25	0.56	damaging	0.13	damaging	4.29	24.00	deleterious	0.19	0.55	0.85	disease	0.79	disease	0.69	disease	0.65	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-1.88	low_impact	-1.48	low_impact	3.75	high_impact	0.70	0.9	5.46	8.09	0.65	P	0.94	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6343	6343	T	G	MI.2812	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	440	147	I	S	aTc/aGc	6.84	1	0	possibly_damaging	0.44	deleterious	0	neutral	2.6	neutral	-2.86	deleterious	-5.21	high_impact	5.25	0.68	neutral	0.19	damaging	4.19	23.90	deleterious	0.19	0.55	0.74	disease	0.82	disease	0.67	disease	0.67	disease	3	1	deleterious	0.28	neutral	5	deleterious	0.40	neutral	-0.66	medium_impact	-1.48	low_impact	3.75	high_impact	0.52	0.9	5.46	8.09	0.65	P	0.62	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6344	6344	C	G	MI.2813	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	441	147	I	M	atC/atG	7.53	1	0	probably_damaging	0.93	neutral	0.06	neutral	2.62	neutral	-2.45	deleterious	-2.6	high_impact	3.68	0.69	neutral	0.15	damaging	3.28	22.80	deleterious	0.27	0.55	0.7	disease	0.6	disease	0.69	disease	0.65	disease	3	0.98	deleterious	0.07	neutral	2	deleterious	0.69	deleterious	-1.81	low_impact	-0.47	medium_impact	2.3	high_impact	0.84	0.9	5.46	8.09	0.53	P	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6344	6344	C	A	MI.2814	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	441	147	I	M	atC/atA	7.53	1	0	probably_damaging	0.93	neutral	0.06	neutral	2.62	neutral	-2.45	deleterious	-2.6	high_impact	3.68	0.69	neutral	0.15	damaging	3.71	23.30	deleterious	0.27	0.55	0.7	disease	0.6	disease	0.69	disease	0.65	disease	3	0.98	deleterious	0.07	neutral	2	deleterious	0.69	deleterious	-1.81	low_impact	-0.47	medium_impact	2.3	high_impact	0.84	0.9	5.46	8.09	0.53	P	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6345	6345	T	C	MI.2815	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	442	148	F	L	Ttc/Ctc	-2.42	0	0	probably_damaging	1	neutral	0.11	neutral	2.99	neutral	1.21	deleterious	-5.2	medium_impact	2.43	0.37	damaging	0.58	neutral	3.95	23.60	deleterious	0.41	0.55	0.17	neutral	0.57	disease	0.49	neutral	0.16	neutral	7	1	deleterious	0.06	neutral	1	deleterious	0.68	deleterious	-3.58	low_impact	-0.31	medium_impact	1.15	medium_impact	0.85	0.9	1.36	7.62	0.64	P	0.83	disease_causing	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6345	6345	T	G	MI.2816	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	442	148	F	V	Ttc/Gtc	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	0.38	deleterious	-6.07	high_impact	3.6	0.51	damaging	0.42	neutral	3.97	23.60	deleterious	0.19	0.55	0.28	neutral	0.8	disease	0.65	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.76	0.9	1.36	7.62	0.4	N	0.84	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6345	6345	T	A	MI.2817	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	442	148	F	I	Ttc/Atc	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	0.26	deleterious	-5.2	high_impact	3.75	0.58	damaging	0.56	neutral	4.29	24.00	deleterious	0.19	0.55	0.22	neutral	0.73	disease	0.63	disease	0.53	disease	1	1	deleterious	0	neutral	6	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	2.36	high_impact	0.73	0.9	1.36	7.62	0.4	N	0.88	disease_causing	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6346	6346	T	C	MI.2818	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	443	148	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-1.59	deleterious	-6.94	high_impact	4.27	0.64	neutral	0.52	neutral	4.11	23.70	deleterious	0.13	0.55	0.2	neutral	0.8	disease	0.69	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.84	high_impact	0.70	0.9	1.36	7.62	0.5	P	0.84	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6346	6346	T	G	MI.2819	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	443	148	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-3.28	deleterious	-6.94	high_impact	4.82	0.55	damaging	0.45	neutral	4.00	23.60	deleterious	0.15	0.55	0.65	disease	0.79	disease	0.71	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.50	0.9	1.36	7.62	0.66	P	0.91	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8657	8657	C	G	MI.282	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	131	44	T	S	aCc/aGc	-3.11	0	0	benign	0.09	neutral	0.9	neutral	4.5	neutral	0.99	neutral	-0.95	neutral_impact	0.43	0.86	neutral	0.91	neutral	-0.48	0.25	neutral	0.46	0.65	0.36	neutral	0.26	neutral	0.23	neutral	0.45	neutral	1	0.03	neutral	0.91	deleterious	-6	neutral	0.18	neutral	0.2	medium_impact	0.83	medium_impact	-0.73	medium_impact	0.80	0.9	21.24	19.09	0.28	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6346	6346	T	A	MI.2820	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	443	148	F	Y	tTc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-2.47	deleterious	-2.6	high_impact	4.12	0.57	damaging	0.43	neutral	4.14	23.80	deleterious	0.21	0.55	0.53	disease	0.69	disease	0.7	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.78	0.9	1.36	7.62	0.59	P	0.59	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6347	6347	C	A	MI.2821	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	444	148	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	neutral	0.11	neutral	2.99	neutral	1.21	deleterious	-5.2	medium_impact	2.43	0.37	damaging	0.58	neutral	4.53	24.30	deleterious	0.41	0.55	0.17	neutral	0.57	disease	0.49	neutral	0.16	neutral	7	1	deleterious	0.06	neutral	1	deleterious	0.68	deleterious	-3.58	low_impact	-0.31	medium_impact	1.15	medium_impact	0.85	0.9	1.36	7.62	0.75	P	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6347	6347	C	G	MI.2822	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	444	148	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	neutral	0.11	neutral	2.99	neutral	1.21	deleterious	-5.2	medium_impact	2.43	0.37	damaging	0.58	neutral	4.28	24.00	deleterious	0.41	0.55	0.17	neutral	0.57	disease	0.49	neutral	0.16	neutral	7	1	deleterious	0.06	neutral	1	deleterious	0.68	deleterious	-3.58	low_impact	-0.31	medium_impact	1.15	medium_impact	0.85	0.9	1.36	7.62	0.75	P	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6348	6348	T	G	MI.2823	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	445	149	S	A	Tcc/Gcc	-1.49	0	0	probably_damaging	0.99	deleterious	0.04	neutral	2.84	neutral	-0.93	neutral	-2.48	medium_impact	2.76	0.54	damaging	0.57	neutral	3.48	23.10	deleterious	0.27	0.55	0.28	neutral	0.5	disease	0.43	neutral	0.37	neutral	3	1	deleterious	0.03	neutral	5	deleterious	0.70	deleterious	-2.64	low_impact	-0.58	medium_impact	1.45	medium_impact	0.65	0.9	1.56	6.75	0.44	N	0.35	polymorphism	0.92	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6348	6348	T	C	MI.2824	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	445	149	S	P	Tcc/Ccc	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.75	deleterious	-4.29	high_impact	5.17	0.34	damaging	0.6	neutral	3.80	23.40	deleterious	0.13	0.55	0.75	disease	0.82	disease	0.74	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.64	0.9	1.56	6.75	0.79	P	0.91	disease_causing	0.66	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6348	6348	T	A	MI.2825	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	445	149	S	T	Tcc/Acc	-1.49	0	0	probably_damaging	0.97	deleterious	0	neutral	2.7	deleterious	-3	deleterious	-2.56	high_impact	4.28	0.46	damaging	0.53	neutral	3.61	23.20	deleterious	0.21	0.55	0.54	disease	0.64	disease	0.63	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.75	deleterious	-2.18	low_impact	-1.48	low_impact	2.85	high_impact	0.77	0.9	1.56	6.75	0.51	P	0.43	polymorphism	0.77	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6349	6349	C	G	MI.2826	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	446	149	S	C	tCc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-4.95	deleterious	-4.26	high_impact	5.17	0.44	damaging	0.48	neutral	3.49	23.10	deleterious	0.14	0.55	0.81	disease	0.79	disease	0.61	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.68	0.9	1.56	6.75	0.72	P	0.85	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6349	6349	C	T	MI.2827	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	446	149	S	F	tCc/tTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-2.83	deleterious	-5.15	high_impact	4.62	0.37	damaging	0.52	neutral	4.18	23.80	deleterious	0.11	0.55	0.74	disease	0.89	disease	0.6	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.51	0.9	1.56	6.75	0.75	P	0.98	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6349	6349	C	A	MI.2828	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	446	149	S	Y	tCc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.69	deleterious	-5.15	high_impact	5.17	0.45	damaging	0.46	neutral	4.00	23.60	deleterious	0.1	0.55	0.78	disease	0.86	disease	0.65	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.69	0.9	1.56	6.75	0.71	P	0.92	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6351	6351	T	A	MI.2829	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	448	150	L	M	Tta/Ata	-10.98	0	0	probably_damaging	1	deleterious	0	neutral	2.43	neutral	-2.38	neutral	-1.73	high_impact	3.88	0.57	damaging	0.08	damaging	3.51	23.10	deleterious	0.28	0.55	0.56	disease	0.62	disease	0.54	disease	0.63	disease	3	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.48	high_impact	0.72	0.9	1.36	6.64	0.29	N	0.59	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8657	8657	C	A	MI.283	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	131	44	T	N	aCc/aAc	-3.11	0	0	benign	0.35	neutral	0.22	neutral	4.47	neutral	0.75	deleterious	-2.59	medium_impact	2.15	0.8	neutral	0.68	neutral	1.84	15.22	deleterious	0.48	0.65	0.35	neutral	0.76	disease	0.31	neutral	0.57	disease	1	0.74	neutral	0.44	neutral	-3	neutral	0.43	neutral	-0.5	medium_impact	-0.02	medium_impact	0.75	medium_impact	0.80	0.9	21.24	19.09	0.33	N	0.59	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6351	6351	T	G	MI.2830	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	448	150	L	V	Tta/Gta	-10.98	0	0	probably_damaging	0.99	deleterious	0	neutral	2.64	neutral	-1.53	deleterious	-2.6	high_impact	3.66	0.53	damaging	0.07	damaging	3.31	22.90	deleterious	0.33	0.55	0.33	neutral	0.66	disease	0.63	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.28	high_impact	0.61	0.9	1.36	6.64	0.28	N	0.66	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6352	6352	T	C	MI.2831	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	449	150	L	S	tTa/tCa	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-3.77	deleterious	-5.2	high_impact	4.92	0.55	damaging	0.07	damaging	3.63	23.20	deleterious	0.18	0.55	0.65	disease	0.81	disease	0.65	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.63	0.9	1.36	6.64	0.59	P	0.73	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6352	6352	T	G	MI.2832	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	449	150	L	W	tTa/tGa	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.38	deleterious	-4.18	deleterious	-5.21	high_impact	4.92	0.52	damaging	0.05	damaging	3.67	23.30	deleterious	0.1	0.55	0.89	disease	0.76	disease	0.58	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.43	0.9	1.36	6.64	0.55	P	0.92	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6353	6353	A	C	MI.2833	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	450	150	L	F	ttA/ttC	4.76	0.72	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-3.45	deleterious	-3.47	high_impact	4.58	0.52	damaging	0.05	damaging	3.35	22.90	deleterious	0.32	0.55	0.65	disease	0.77	disease	0.57	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.63	0.9	1.36	6.64	0.43	N	0.87	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6353	6353	A	T	MI.2834	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	450	150	L	F	ttA/ttT	4.76	0.72	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-3.45	deleterious	-3.47	high_impact	4.58	0.52	damaging	0.05	damaging	3.43	23.00	deleterious	0.32	0.55	0.65	disease	0.77	disease	0.57	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.63	0.9	1.36	6.64	0.45	N	0.87	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6354	6354	C	T	MI.2835	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	451	151	H	Y	Cac/Tac	-14.68	0	0	probably_damaging	0.99	deleterious	0	neutral	2.78	neutral	-2.48	deleterious	-5.21	high_impact	4.43	0.49	damaging	0.02	damaging	3.58	23.20	deleterious	0.43	0.55	0.53	disease	0.84	disease	0.72	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.99	high_impact	0.60	0.9	3.7	6.68	0.39	N	0.72	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6354	6354	C	A	MI.2836	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	451	151	H	N	Cac/Aac	-14.68	0	0	probably_damaging	0.99	deleterious	0	neutral	2.76	deleterious	-3.4	deleterious	-6.08	high_impact	5.24	0.49	damaging	0.02	damaging	3.76	23.30	deleterious	0.41	0.55	0.54	disease	0.78	disease	0.71	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	3.74	high_impact	0.61	0.9	3.7	6.68	0.54	N	0.86	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6354	6354	C	G	MI.2837	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	451	151	H	D	Cac/Gac	-14.68	0	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.83	deleterious	-7.81	high_impact	5.24	0.45	damaging	0.02	damaging	3.75	23.30	deleterious	0.22	0.55	0.6	disease	0.84	disease	0.79	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.55	0.9	3.7	6.68	0.49	N	0.97	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6355	6355	A	G	MI.2838	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	452	151	H	R	cAc/cGc	5.68	1	0	probably_damaging	0.99	deleterious	0	neutral	2.78	neutral	-2.59	deleterious	-6.95	high_impact	5.24	0.52	damaging	0.02	damaging	2.77	21.20	deleterious	0.43	0.55	0.51	disease	0.84	disease	0.75	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	3.74	high_impact	0.44	0.9	3.7	6.68	0.65	P	0.85	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6355	6355	A	T	MI.2839	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	452	151	H	L	cAc/cTc	5.68	1	0	probably_damaging	0.99	deleterious	0	neutral	2.9	neutral	-0.68	deleterious	-9.55	high_impact	3.69	0.58	damaging	0.03	damaging	3.60	23.20	deleterious	0.22	0.55	0.27	neutral	0.88	disease	0.7	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.31	high_impact	0.37	0.9	3.7	6.68	0.48	N	0.92	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8659	8659	A	T	MI.284	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	133	45	T	S	Acc/Tcc	-20	0	0.01	benign	0.14	neutral	0.13	neutral	4.43	neutral	0.63	neutral	-1.29	neutral_impact	-0.21	0.9	neutral	0.74	neutral	1.85	15.31	deleterious	0.47	0.65	0.41	neutral	0.26	neutral	0.53	disease	0.47	neutral	1	0.85	neutral	0.5	deleterious	-6	neutral	0.22	neutral	-0.01	medium_impact	-0.18	medium_impact	-1.28	low_impact	0.70	0.9	18.14	18.2	0.41	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6355	6355	A	C	MI.2840	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	452	151	H	P	cAc/cCc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.76	deleterious	-3.28	deleterious	-8.68	high_impact	5.24	0.42	damaging	0.03	damaging	3.05	22.40	deleterious	0.24	0.55	0.65	disease	0.86	disease	0.81	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.47	0.9	3.7	6.68	0.69	P	0.90	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6356	6356	C	A	MI.2841	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	453	151	H	Q	caC/caA	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.8	neutral	-2.09	deleterious	-6.95	high_impact	4.43	0.57	damaging	0.02	damaging	3.82	23.40	deleterious	0.46	0.55	0.27	neutral	0.79	disease	0.67	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.99	high_impact	0.52	0.9	3.7	6.68	0.43	N	0.83	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6356	6356	C	G	MI.2842	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	453	151	H	Q	caC/caG	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.8	neutral	-2.09	deleterious	-6.95	high_impact	4.43	0.57	damaging	0.02	damaging	3.48	23.10	deleterious	0.46	0.55	0.27	neutral	0.79	disease	0.67	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.99	high_impact	0.52	0.9	3.7	6.68	0.43	N	0.83	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6357	6357	C	G	MI.2843	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	454	152	L	V	Cta/Gta	-1.49	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.56	neutral	-1.2	neutral	-2.32	medium_impact	3.04	0.36	damaging	0.29	neutral	3.26	22.80	deleterious	0.4	0.55	0.28	neutral	0.63	disease	0.36	neutral	0.2	neutral	6	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-2.64	low_impact	-0.92	medium_impact	1.71	medium_impact	0.68	0.9	1.95	6.79	0.55	P	0.66	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6357	6357	C	A	MI.2844	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	454	152	L	M	Cta/Ata	-1.49	0	0	probably_damaging	1	deleterious	0.03	neutral	2.37	deleterious	-3.56	neutral	-1.41	medium_impact	2.19	0.4	damaging	0.55	neutral	3.73	23.30	deleterious	0.31	0.55	0.55	disease	0.44	neutral	0.32	neutral	0.53	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-0.65	medium_impact	0.92	medium_impact	0.71	0.9	1.95	6.79	0.6	P	0.59	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6358	6358	T	C	MI.2845	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	455	152	L	P	cTa/cCa	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.34	deleterious	-5.43	deleterious	-5.82	high_impact	5	0.33	damaging	0.26	damaging	3.80	23.40	deleterious	0.17	0.55	0.48	neutral	0.87	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.70	0.9	1.95	6.79	0.6	P	0.83	disease_causing	0.6	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6358	6358	T	G	MI.2846	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	455	152	L	R	cTa/cGa	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.35	deleterious	-4.88	deleterious	-4.99	high_impact	5	0.41	damaging	0.23	damaging	4.07	23.70	deleterious	0.13	0.55	0.69	disease	0.91	disease	0.7	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.54	0.9	1.95	6.79	0.63	P	0.90	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6358	6358	T	A	MI.2847	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	455	152	L	Q	cTa/cAa	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.34	deleterious	-5.05	deleterious	-4.93	high_impact	5	0.42	damaging	0.3	neutral	3.99	23.60	deleterious	0.15	0.55	0.71	disease	0.84	disease	0.58	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.72	0.9	1.95	6.79	0.62	P	0.82	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6360	6360	G	C	MI.2848	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	457	153	A	P	Gca/Cca	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-3.73	deleterious	-4.21	high_impact	4.8	0.51	damaging	0.04	damaging	3.72	23.30	deleterious	0.11	0.55	0.67	disease	0.91	disease	0.72	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.33	high_impact	0.78	0.9	2.92	6.73	0.63	P	0.85	polymorphism	0.77	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6360	6360	G	T	MI.2849	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	457	153	A	S	Gca/Tca	-4.5	0	0	probably_damaging	1	deleterious	0.03	neutral	2.77	neutral	-0.34	neutral	-2.35	medium_impact	2.75	0.6	neutral	0.05	damaging	3.54	23.10	deleterious	0.46	0.55	0.21	neutral	0.76	disease	0.33	neutral	0.19	neutral	6	1	deleterious	0.02	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.65	medium_impact	1.44	medium_impact	0.90	0.95	2.92	6.73	0.28	N	0.64	polymorphism	0.96	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8659	8659	A	G	MI.285	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	133	45	T	A	Acc/Gcc	-20	0	0.01	benign	0.01	neutral	0.19	neutral	4.49	neutral	1.34	neutral	-0.59	neutral_impact	-0.5	0.93	neutral	0.87	neutral	1.87	15.39	deleterious	0.61	0.7	0.42	neutral	0.2	neutral	0.29	neutral	0.38	neutral	2	0.81	neutral	0.59	deleterious	-6	neutral	0.16	neutral	1.14	medium_impact	-0.06	medium_impact	-1.53	low_impact	0.52	0.9	18.14	18.2	0.44	N	0.22	polymorphism	1	0.01	rs879150284	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6360	6360	G	A	MI.2850	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	457	153	A	T	Gca/Aca	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-1.35	deleterious	-3.28	high_impact	3.6	0.6	damaging	0.06	damaging	4.12	23.80	deleterious	0.54	0.6	0.19	neutral	0.79	disease	0.38	neutral	0.19	neutral	6	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.78	0.9	2.92	6.73	0.3	N	0.20	polymorphism	0.92	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6361	6361	C	A	MI.2851	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	458	153	A	E	gCa/gAa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-3.15	deleterious	-4.17	high_impact	5.14	0.58	damaging	0.06	damaging	4.40	24.10	deleterious	0.18	0.55	0.51	disease	0.92	disease	0.69	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.73	0.9	2.92	6.73	0.69	P	0.76	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6361	6361	C	G	MI.2852	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	458	153	A	G	gCa/gGa	7.53	1	0	probably_damaging	1	deleterious	0.03	neutral	2.66	neutral	-2.17	deleterious	-3.35	high_impact	3.65	0.61	neutral	0.05	damaging	3.82	23.40	deleterious	0.36	0.55	0.59	disease	0.82	disease	0.5	neutral	0.47	neutral	1	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-0.65	medium_impact	2.27	high_impact	0.81	0.9	2.92	6.73	0.44	N	0.56	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6361	6361	C	T	MI.2853	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	458	153	A	V	gCa/gTa	7.53	1	0	probably_damaging	1	deleterious	0.04	neutral	2.89	neutral	0.59	deleterious	-3.42	high_impact	3.95	0.58	damaging	0.04	damaging	4.30	24.00	deleterious	0.41	0.55	0.32	neutral	0.88	disease	0.58	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-0.58	medium_impact	2.55	high_impact	0.75	0.9	2.92	6.73	0.5	P	0.75	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6363	6363	G	C	MI.2854	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	460	154	G	R	Ggt/Cgt	-9.82	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-3.61	deleterious	-6.95	high_impact	5.31	0.56	damaging	0.07	damaging	3.89	23.50	deleterious	0.14	0.55	0.8	disease	0.91	disease	0.8	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.77	0.9	1.75	6.74	0.61	P	0.95	polymorphism	0.7	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6363	6363	G	A	MI.2855	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	460	154	G	S	Ggt/Agt	-9.82	0	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-2.78	deleterious	-5.21	high_impact	4.42	0.64	neutral	0.1	damaging	4.06	23.70	deleterious	0.25	0.55	0.57	disease	0.86	disease	0.65	disease	0.58	disease	2	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.59	0.9	1.75	6.74	0.43	N	0.73	polymorphism	0.83	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6363	6363	G	T	MI.2856	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	460	154	G	C	Ggt/Tgt	-9.82	0	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-4.62	deleterious	-7.83	high_impact	4.96	0.54	damaging	0.09	damaging	4.05	23.70	deleterious	0.14	0.55	0.92	disease	0.92	disease	0.69	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.67	0.9	1.75	6.74	0.54	P	0.98	polymorphism	0.55	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6364	6364	G	T	MI.2857	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	461	154	G	V	gGt/gTt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-1.11	deleterious	-7.82	high_impact	4.96	0.49	damaging	0.1	damaging	3.67	23.20	deleterious	0.13	0.55	0.77	disease	0.91	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.65	0.9	1.75	6.74	0.67	P	0.93	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6364	6364	G	C	MI.2858	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	461	154	G	A	gGt/gCt	9.15	1	0	probably_damaging	1	deleterious	0.01	neutral	2.68	neutral	-2.29	deleterious	-5.21	high_impact	5.31	0.7	neutral	0.14	damaging	3.00	22.20	deleterious	0.23	0.55	0.66	disease	0.74	disease	0.66	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.92	medium_impact	3.8	high_impact	0.67	0.9	1.75	6.74	0.71	P	0.64	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6364	6364	G	A	MI.2859	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	461	154	G	D	gGt/gAt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-3.74	deleterious	-6.08	high_impact	4.96	0.54	damaging	0.08	damaging	3.67	23.30	deleterious	0.15	0.55	0.72	disease	0.92	disease	0.78	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.49	0.9	1.75	6.74	0.69	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8659	8659	A	C	MI.286	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	133	45	T	P	Acc/Ccc	-20	0	0.01	possibly_damaging	0.48	deleterious	0.01	neutral	4.34	neutral	-1.92	neutral	-2.32	neutral_impact	0.67	0.8	neutral	0.42	neutral	3.52	23.10	deleterious	0.14	0.65	0.78	disease	0.77	disease	0.67	disease	0.79	disease	6	0.99	deleterious	0.27	neutral	1	deleterious	0.66	deleterious	-0.72	medium_impact	-0.84	medium_impact	-0.52	medium_impact	0.64	0.9	18.14	18.2	0.29	N	0.35	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6366	6366	G	C	MI.2860	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	463	155	V	L	Gtc/Ctc	-20	0	0.01	benign	0.01	neutral	0.19	neutral	2.62	neutral	-1.73	neutral	-1.11	low_impact	1.74	0.87	neutral	0.54	neutral	1.50	13.30	neutral	0.55	0.6	0.2	neutral	0.66	disease	0.32	neutral	0.23	neutral	5	0.81	neutral	0.59	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	-0.16	medium_impact	0.51	medium_impact	0.79	0.9	12.48	34.19	0.38	N	0.24	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6366	6366	G	T	MI.2861	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	463	155	V	F	Gtc/Ttc	-20	0	0.01	possibly_damaging	0.53	deleterious	0	neutral	2.47	deleterious	-3.85	deleterious	-2.59	medium_impact	2.21	0.68	neutral	0.49	neutral	2.10	16.83	deleterious	0.19	0.55	0.25	neutral	0.88	disease	0.5	neutral	0.55	disease	1	1	deleterious	0.24	neutral	4	deleterious	0.50	deleterious	-0.81	medium_impact	-1.48	low_impact	0.94	medium_impact	0.62	0.9	12.48	34.19	0.38	N	0.77	polymorphism	0.93	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6366	6366	G	A	MI.2862	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	463	155	V	I	Gtc/Atc	-20	0	0.01	benign	0	neutral	1	neutral	2.77	neutral	-0.83	neutral	-0.1	neutral_impact	-0.44	0.8	neutral	0.97	neutral	-1.16	0.01	neutral	0.53	0.6	0.17	neutral	0.11	neutral	0.22	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	1.86	high_impact	-1.51	low_impact	0.72	0.9	12.48	34.19	0.32	N	0.00	polymorphism	1	0.01	rs370673798	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6367	6367	T	C	MI.2863	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	464	155	V	A	gTc/gCc	0.36	0.13	0	benign	0.26	neutral	0.23	neutral	2.63	neutral	-1.68	neutral	-1.25	neutral_impact	0.16	0.75	neutral	0.74	neutral	-0.33	0.58	neutral	0.46	0.55	0.31	neutral	0.25	neutral	0.33	neutral	0.43	neutral	1	0.72	neutral	0.49	deleterious	-6	neutral	0.23	neutral	-0.33	medium_impact	-0.1	medium_impact	-0.95	medium_impact	0.56	0.9	12.48	34.19	0.51	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6367	6367	T	A	MI.2864	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	464	155	V	D	gTc/gAc	0.36	0.13	0	possibly_damaging	0.74	deleterious	0	neutral	2.42	deleterious	-7.08	deleterious	-4.23	high_impact	3.96	0.7	neutral	0.39	neutral	4.06	23.70	deleterious	0.11	0.55	0.81	disease	0.88	disease	0.7	disease	0.75	disease	5	1	deleterious	0.13	neutral	5	deleterious	0.75	deleterious	-1.18	low_impact	-1.48	low_impact	2.56	high_impact	0.68	0.9	12.48	34.19	0.38	N	0.88	polymorphism	0.97	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6367	6367	T	G	MI.2865	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	464	155	V	G	gTc/gGc	0.36	0.13	0	possibly_damaging	0.73	deleterious	0	neutral	2.43	deleterious	-5.39	deleterious	-4.06	high_impact	3.96	0.74	neutral	0.56	neutral	3.46	23.00	deleterious	0.21	0.55	0.68	disease	0.77	disease	0.59	disease	0.71	disease	4	1	deleterious	0.14	neutral	5	deleterious	0.69	deleterious	-1.16	low_impact	-1.48	low_impact	2.56	high_impact	0.54	0.9	12.48	34.19	0.41	N	0.67	polymorphism	0.96	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6369	6369	T	A	MI.2866	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	466	156	S	T	Tcc/Acc	-12.13	0	0	probably_damaging	0.99	deleterious	0	neutral	2.56	neutral	-2.37	deleterious	-2.61	high_impact	5.24	0.51	damaging	0.15	damaging	3.64	23.20	deleterious	0.3	0.55	0.56	disease	0.77	disease	0.72	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	3.74	high_impact	0.73	0.9	5.46	8.32	0.67	P	0.43	polymorphism	0.99	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6369	6369	T	C	MI.2867	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	466	156	S	P	Tcc/Ccc	-12.13	0	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.18	deleterious	-4.35	high_impact	5.24	0.4	damaging	0.2	damaging	3.85	23.40	deleterious	0.19	0.55	0.76	disease	0.9	disease	0.81	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.59	0.9	5.46	8.32	0.67	P	0.91	polymorphism	0.97	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6369	6369	T	G	MI.2868	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	466	156	S	A	Tcc/Gcc	-12.13	0	0	probably_damaging	0.99	deleterious	0.02	neutral	2.72	neutral	-0.54	deleterious	-2.61	medium_impact	3.49	0.59	damaging	0.18	damaging	3.54	23.10	deleterious	0.33	0.55	0.37	neutral	0.69	disease	0.64	disease	0.54	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.75	deleterious	-2.64	low_impact	-0.75	medium_impact	2.12	high_impact	0.71	0.9	5.46	8.32	0.31	N	0.35	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6370	6370	C	T	MI.2869	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	467	156	S	F	tCc/tTc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.16	deleterious	-5.21	high_impact	4.89	0.34	damaging	0.08	damaging	4.18	23.80	deleterious	0.14	0.55	0.79	disease	0.94	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.50	0.9	5.46	8.32	0.74	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8660	8660	C	A	MI.287	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	134	45	T	N	aCc/aAc	-2.65	0	0	possibly_damaging	0.48	deleterious	0	neutral	4.35	neutral	-1.61	neutral	-2.26	low_impact	0.92	0.83	neutral	0.63	neutral	3.13	22.60	deleterious	0.32	0.65	0.74	disease	0.51	disease	0.56	disease	0.66	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.57	deleterious	-0.72	medium_impact	-1.4	low_impact	-0.31	medium_impact	0.73	0.9	18.14	18.2	0.34	N	0.31	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6370	6370	C	G	MI.2870	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	467	156	S	C	tCc/tGc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-5.13	deleterious	-4.35	high_impact	5.24	0.45	damaging	0.11	damaging	3.49	23.10	deleterious	0.21	0.55	0.86	disease	0.87	disease	0.7	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.67	0.9	5.46	8.32	0.68	P	0.85	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6370	6370	C	A	MI.2871	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	467	156	S	Y	tCc/tAc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.28	deleterious	-5.22	high_impact	5.24	0.47	damaging	0.12	damaging	4.01	23.60	deleterious	0.15	0.55	0.79	disease	0.92	disease	0.73	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.63	0.9	5.46	8.32	0.69	P	0.92	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6372	6372	T	C	MI.2872	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	469	157	S	P	Tct/Cct	-14.45	0	0	probably_damaging	0.99	deleterious	0	neutral	2.66	deleterious	-4.01	deleterious	-4.35	high_impact	4.92	0.3	damaging	0.06	damaging	3.87	23.50	deleterious	0.2	0.55	0.81	disease	0.88	disease	0.79	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.64	low_impact	-1.48	low_impact	3.44	high_impact	0.54	0.9	2.73	6.64	0.62	P	0.91	polymorphism	0.92	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6372	6372	T	G	MI.2873	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	469	157	S	A	Tct/Gct	-14.45	0	0	probably_damaging	0.97	deleterious	0	neutral	2.74	neutral	-1.86	deleterious	-2.61	high_impact	4.12	0.54	damaging	0.11	damaging	3.62	23.20	deleterious	0.34	0.55	0.54	disease	0.68	disease	0.68	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.18	low_impact	-1.48	low_impact	2.71	high_impact	0.70	0.9	2.73	6.64	0.29	N	0.35	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6372	6372	T	A	MI.2874	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	469	157	S	T	Tct/Act	-14.45	0	0	probably_damaging	0.95	deleterious	0	neutral	2.77	neutral	-1.49	deleterious	-2.6	medium_impact	3.27	0.45	damaging	0.07	damaging	3.68	23.30	deleterious	0.32	0.55	0.3	neutral	0.75	disease	0.67	disease	0.67	disease	3	1	deleterious	0.03	neutral	5	deleterious	0.73	deleterious	-1.96	low_impact	-1.48	low_impact	1.92	medium_impact	0.72	0.9	2.73	6.64	0.32	N	0.43	polymorphism	0.99	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6373	6373	C	A	MI.2875	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	470	157	S	Y	tCt/tAt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.41	deleterious	-5.22	high_impact	5.26	0.44	damaging	0.04	damaging	3.90	23.50	deleterious	0.18	0.55	0.85	disease	0.92	disease	0.7	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.62	0.9	2.73	6.64	0.71	P	0.92	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6373	6373	C	T	MI.2876	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	470	157	S	F	tCt/tTt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.02	deleterious	-5.22	high_impact	4.71	0.41	damaging	0.02	damaging	4.06	23.70	deleterious	0.14	0.55	0.84	disease	0.93	disease	0.7	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.25	high_impact	0.31	0.9	2.73	6.64	0.73	P	0.98	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6373	6373	C	G	MI.2877	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	470	157	S	C	tCt/tGt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-4.51	deleterious	-4.35	high_impact	5.26	0.44	damaging	0.02	damaging	3.47	23.00	deleterious	0.2	0.55	0.87	disease	0.86	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.62	0.9	2.73	6.64	0.69	P	0.85	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6375	6375	A	C	MI.2878	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	472	158	I	L	Atc/Ctc	-7.28	0	0	probably_damaging	0.94	neutral	0.05	neutral	2.86	neutral	-0.17	neutral	-1.72	medium_impact	2.5	0.67	neutral	0.06	damaging	3.70	23.30	deleterious	0.35	0.55	0.29	neutral	0.66	disease	0.36	neutral	0.18	neutral	6	0.99	deleterious	0.06	neutral	1	deleterious	0.59	deleterious	-1.88	low_impact	-0.52	medium_impact	1.21	medium_impact	0.70	0.9	2.34	6.75	0.3	N	0.61	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6375	6375	A	G	MI.2879	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	472	158	I	V	Atc/Gtc	-7.28	0	0	possibly_damaging	0.85	deleterious	0	neutral	2.72	neutral	-1.18	neutral	-0.87	high_impact	3.78	0.65	neutral	0.08	damaging	2.90	21.90	deleterious	0.53	0.6	0.45	neutral	0.54	disease	0.55	disease	0.48	neutral	0	1	deleterious	0.08	neutral	5	deleterious	0.58	deleterious	-1.47	low_impact	-1.48	low_impact	2.39	high_impact	0.54	0.9	2.34	6.75	0.33	N	0.23	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8660	8660	C	G	MI.288	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	134	45	T	S	aCc/aGc	-2.65	0	0	benign	0.14	neutral	0.13	neutral	4.43	neutral	0.63	neutral	-1.29	neutral_impact	-0.21	0.9	neutral	0.74	neutral	1.59	13.79	neutral	0.47	0.65	0.41	neutral	0.26	neutral	0.53	disease	0.47	neutral	1	0.85	neutral	0.5	deleterious	-6	neutral	0.22	neutral	-0.01	medium_impact	-0.18	medium_impact	-1.28	low_impact	0.70	0.9	18.14	18.2	0.41	N	0.20	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6375	6375	A	T	MI.2880	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	472	158	I	F	Atc/Ttc	-7.28	0	0	probably_damaging	0.99	deleterious	0	neutral	2.59	neutral	-2.78	deleterious	-3.47	high_impact	4.64	0.61	neutral	0.05	damaging	3.78	23.40	deleterious	0.25	0.55	0.8	disease	0.87	disease	0.64	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.64	low_impact	-1.48	low_impact	3.19	high_impact	0.74	0.9	2.34	6.75	0.45	N	0.85	disease_causing	0.68	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6376	6376	T	C	MI.2881	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	473	158	I	T	aTc/aCc	8.69	1	0	probably_damaging	1	deleterious	0.02	neutral	2.7	neutral	-0.94	deleterious	-4.33	high_impact	3.63	0.62	neutral	0.08	damaging	3.29	22.80	deleterious	0.37	0.55	0.53	disease	0.77	disease	0.55	disease	0.49	neutral	0	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-0.75	medium_impact	2.25	high_impact	0.58	0.9	2.34	6.75	0.45	N	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6376	6376	T	A	MI.2882	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	473	158	I	N	aTc/aAc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-3.76	deleterious	-6.08	high_impact	5.2	0.61	neutral	0.07	damaging	4.35	24.10	deleterious	0.22	0.55	0.93	disease	0.86	disease	0.63	disease	0.63	disease	3	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.58	0.9	2.34	6.75	0.69	P	0.94	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6376	6376	T	G	MI.2883	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	473	158	I	S	aTc/aGc	8.69	1	0	probably_damaging	1	deleterious	0.03	neutral	2.58	neutral	-2.52	deleterious	-5.21	high_impact	4.64	0.64	neutral	0.09	damaging	4.20	23.90	deleterious	0.2	0.55	0.87	disease	0.89	disease	0.6	disease	0.63	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-0.65	medium_impact	3.19	high_impact	0.40	0.9	2.34	6.75	0.55	P	0.62	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6377	6377	C	A	MI.2884	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	474	158	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-2.29	deleterious	-2.59	high_impact	3.96	0.66	neutral	0.06	damaging	3.70	23.30	deleterious	0.35	0.55	0.76	disease	0.71	disease	0.53	disease	0.47	neutral	1	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.78	0.9	2.34	6.75	0.45	N	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6377	6377	C	G	MI.2885	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	474	158	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-2.29	deleterious	-2.59	high_impact	3.96	0.66	neutral	0.06	damaging	3.29	22.80	deleterious	0.35	0.55	0.76	disease	0.71	disease	0.53	disease	0.47	neutral	1	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.78	0.9	2.34	6.75	0.45	N	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6378	6378	T	A	MI.2886	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	475	159	L	M	Tta/Ata	-2.42	0	0	probably_damaging	1	neutral	0.05	neutral	2.46	neutral	-1.63	neutral	-1.13	low_impact	1.16	0.46	damaging	0.1	damaging	2.41	18.87	deleterious	0.39	0.55	0.46	neutral	0.38	neutral	0.29	neutral	0.42	neutral	2	1	deleterious	0.03	neutral	-2	neutral	0.72	deleterious	-3.58	low_impact	-0.52	medium_impact	-0.03	medium_impact	0.78	0.9	1.17	6.77	0.4	N	0.59	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6378	6378	T	G	MI.2887	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	475	159	L	V	Tta/Gta	-2.42	0	0	probably_damaging	0.97	deleterious	0	neutral	2.51	neutral	-1.85	neutral	-2.35	medium_impact	3.49	0.53	damaging	0.08	damaging	3.34	22.90	deleterious	0.41	0.55	0.51	disease	0.74	disease	0.49	neutral	0.46	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-2.18	low_impact	-1.48	low_impact	2.12	high_impact	0.66	0.9	1.17	6.77	0.27	N	0.66	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6379	6379	T	G	MI.2888	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	476	159	L	W	tTa/tGa	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.37	deleterious	-5.74	deleterious	-4.85	high_impact	4.96	0.49	damaging	0.05	damaging	3.67	23.20	deleterious	0.15	0.55	0.9	disease	0.85	disease	0.6	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.54	0.9	1.17	6.77	0.54	P	0.92	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6379	6379	T	C	MI.2889	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	476	159	L	S	tTa/tCa	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-3.24	deleterious	-4.84	high_impact	3.76	0.54	damaging	0.07	damaging	3.67	23.30	deleterious	0.26	0.55	0.72	disease	0.85	disease	0.58	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.37	high_impact	0.64	0.9	1.17	6.77	0.29	N	0.73	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8660	8660	C	T	MI.289	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	134	45	T	I	aCc/aTc	-2.65	0	0	benign	0.01	neutral	0.49	neutral	4.53	neutral	1.7	neutral	2.06	neutral_impact	-1.42	0.87	neutral	0.96	neutral	0.50	7.40	deleterious	0.33	0.65	0.27	neutral	0.2	neutral	0.29	neutral	0.36	neutral	3	0.5	neutral	0.74	deleterious	-6	neutral	0.13	neutral	1.14	medium_impact	0.28	medium_impact	-2.31	low_impact	0.63	0.9	18.14	18.2	0.31	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6380	6380	A	C	MI.2890	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	477	159	L	F	ttA/ttC	7.53	0.97	0	probably_damaging	1	deleterious	0.02	neutral	2.42	deleterious	-3.19	deleterious	-3.22	medium_impact	3.37	0.51	damaging	0.05	damaging	3.40	23.00	deleterious	0.4	0.55	0.59	disease	0.83	disease	0.5	neutral	0.59	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.58	low_impact	-0.75	medium_impact	2.01	high_impact	0.68	0.9	1.17	6.77	0.45	N	0.87	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6380	6380	A	T	MI.2891	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	477	159	L	F	ttA/ttT	7.53	0.97	0	probably_damaging	1	deleterious	0.02	neutral	2.42	deleterious	-3.19	deleterious	-3.22	medium_impact	3.37	0.51	damaging	0.05	damaging	3.51	23.10	deleterious	0.4	0.55	0.59	disease	0.83	disease	0.5	neutral	0.59	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.58	low_impact	-0.75	medium_impact	2.01	high_impact	0.68	0.9	1.17	6.77	0.45	N	0.87	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6381	6381	G	C	MI.2892	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	478	160	G	R	Ggg/Cgg	-3.57	0	0	probably_damaging	0.97	deleterious	0.02	neutral	2.78	neutral	-2.88	deleterious	-6.25	high_impact	4.83	0.65	neutral	0.07	damaging	3.89	23.50	deleterious	0.14	0.55	0.67	disease	0.92	disease	0.74	disease	0.73	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.90	deleterious	-2.18	low_impact	-0.75	medium_impact	3.36	high_impact	0.83	0.9	4.48	16.12	0.59	P	0.95	disease_causing	0.59	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6381	6381	G	T	MI.2893	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	478	160	G	W	Ggg/Tgg	-3.57	0	0	probably_damaging	0.99	deleterious	0	neutral	2.82	neutral	-1.91	deleterious	-6.45	high_impact	5.17	0.66	neutral	0.08	damaging	4.38	24.10	deleterious	0.14	0.55	0.92	disease	0.92	disease	0.67	disease	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-2.64	low_impact	-1.48	low_impact	3.68	high_impact	0.41	0.9	4.48	16.12	0.58	P	0.83	disease_causing	0.71	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6382	6382	G	A	MI.2894	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	479	160	G	E	gGg/gAg	5.22	1	0	probably_damaging	0.92	deleterious	0	neutral	2.78	neutral	-2.93	deleterious	-6.24	high_impact	4.83	0.64	neutral	0.09	damaging	3.86	23.50	deleterious	0.22	0.55	0.61	disease	0.92	disease	0.73	disease	0.73	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.87	deleterious	-1.76	low_impact	-1.48	low_impact	3.36	high_impact	0.73	0.9	4.48	16.12	0.67	P	0.93	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6382	6382	G	C	MI.2895	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	479	160	G	A	gGg/gCg	5.22	1	0	benign	0.42	neutral	0.1	neutral	2.88	neutral	-0.93	deleterious	-4.21	medium_impact	2.5	0.64	neutral	0.2	damaging	1.94	15.81	deleterious	0.3	0.55	0.28	neutral	0.68	disease	0.41	neutral	0.17	neutral	7	0.89	neutral	0.34	neutral	-3	neutral	0.55	deleterious	-0.62	medium_impact	-0.34	medium_impact	1.21	medium_impact	0.76	0.9	4.48	16.12	0.51	P	0.64	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6382	6382	G	T	MI.2896	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	479	160	G	V	gGg/gTg	5.22	1	0	probably_damaging	0.97	deleterious	0	neutral	2.85	neutral	-1.33	deleterious	-6.92	high_impact	5.17	0.65	neutral	0.08	damaging	3.70	23.30	deleterious	0.14	0.55	0.57	disease	0.91	disease	0.63	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.18	low_impact	-1.48	low_impact	3.68	high_impact	0.68	0.9	4.48	16.12	0.64	P	0.93	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6384	6384	G	C	MI.2897	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	481	161	A	P	Gcc/Ccc	-12.37	0	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.47	deleterious	-3.89	high_impact	4.99	0.61	neutral	0.15	damaging	3.78	23.40	deleterious	0.13	0.55	0.75	disease	0.94	disease	0.72	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.73	0.9	5.65	17.91	0.65	P	0.85	polymorphism	0.8	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6384	6384	G	T	MI.2898	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	481	161	A	S	Gcc/Tcc	-12.37	0	0	probably_damaging	1	neutral	0.4	neutral	2.7	neutral	-0.67	neutral	-1.69	low_impact	1.04	0.63	neutral	0.51	neutral	2.37	18.62	deleterious	0.32	0.55	0.3	neutral	0.7	disease	0.33	neutral	0.23	neutral	6	1	deleterious	0.2	neutral	-2	neutral	0.78	deleterious	-3.58	low_impact	0.1	medium_impact	-0.14	medium_impact	0.80	0.9	5.65	17.91	0.36	N	0.64	polymorphism	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6384	6384	G	A	MI.2899	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	481	161	A	T	Gcc/Acc	-12.37	0	0	probably_damaging	1	deleterious	0	neutral	2.58	neutral	-2.06	deleterious	-2.86	high_impact	4.29	0.56	damaging	0.19	damaging	4.14	23.80	deleterious	0.4	0.55	0.52	disease	0.89	disease	0.52	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.86	high_impact	0.74	0.9	5.65	17.91	0.38	N	0.20	polymorphism	0.93	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8538	8538	T	G	MI.29	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	12	4	N	K	aaT/aaG	1.75	0.93	0	benign	0.07	deleterious	0	neutral	4.49	neutral	-0.72	deleterious	-3.89	medium_impact	2.85	0.87	neutral	0.35	neutral	4.26	23.90	deleterious	0.63	0.7	0.6	disease	0.52	disease	0.6	disease	0.69	disease	4	1	deleterious	0.47	neutral	1	deleterious	0.33	neutral	0.31	medium_impact	-1.4	low_impact	1.35	medium_impact	0.28	0.9	41.59	7.51	0.48	N	0.94	disease_causing	0.69	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8662	8662	C	G	MI.290	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	136	46	Q	E	Caa/Gaa	-9.82	0	0	probably_damaging	0.94	neutral	0.27	neutral	4.33	neutral	-1.83	deleterious	-2.81	high_impact	3.62	0.85	neutral	0.16	damaging	2.94	22.00	deleterious	0.46	0.65	0.77	disease	0.76	disease	0.59	disease	0.66	disease	3	0.95	neutral	0.17	neutral	2	deleterious	0.82	deleterious	-1.89	low_impact	0.05	medium_impact	2.01	high_impact	0.84	0.9	49.56	8.75	0.28	N	0.94	polymorphism	0.99	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6385	6385	C	A	MI.2900	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	482	161	A	D	gCc/gAc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.65	deleterious	-4.45	high_impact	4.99	0.64	neutral	0.13	damaging	4.38	24.10	deleterious	0.11	0.55	0.68	disease	0.95	disease	0.7	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.70	0.9	5.65	17.91	0.68	P	0.89	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6385	6385	C	G	MI.2901	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	482	161	A	G	gCc/gGc	9.15	1	0	probably_damaging	1	neutral	0.06	neutral	2.63	neutral	-1.35	deleterious	-3.02	medium_impact	3.42	0.63	neutral	0.17	damaging	3.86	23.50	deleterious	0.23	0.55	0.3	neutral	0.86	disease	0.5	neutral	0.51	disease	0	1	deleterious	0.03	neutral	1	deleterious	0.75	deleterious	-3.58	low_impact	-0.47	medium_impact	2.06	high_impact	0.77	0.9	5.65	17.91	0.52	P	0.56	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6385	6385	C	T	MI.2902	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	482	161	A	V	gCc/gTc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.62	neutral	-1.43	deleterious	-3.32	high_impact	4.99	0.61	neutral	0.14	damaging	4.41	24.10	deleterious	0.39	0.55	0.49	neutral	0.91	disease	0.6	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.75	0.9	5.65	17.91	0.71	P	0.75	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6387	6387	A	C	MI.2903	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	484	162	I	L	Atc/Ctc	-11.44	0	0	probably_damaging	0.98	neutral	0.06	neutral	2.72	neutral	-0.48	neutral	-1.66	medium_impact	2.12	0.51	damaging	0.1	damaging	2.64	20.50	deleterious	0.34	0.55	0.39	neutral	0.72	disease	0.32	neutral	0.36	neutral	3	1	deleterious	0.04	neutral	1	deleterious	0.68	deleterious	-2.35	low_impact	-0.47	medium_impact	0.86	medium_impact	0.77	0.9	0.97	6.72	0.33	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6387	6387	A	T	MI.2904	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	484	162	I	F	Atc/Ttc	-11.44	0	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-1.2	deleterious	-3.42	high_impact	4.81	0.52	damaging	0.05	damaging	3.81	23.40	deleterious	0.26	0.55	0.81	disease	0.89	disease	0.59	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.34	high_impact	0.78	0.9	0.97	6.72	0.62	P	0.85	polymorphism	0.72	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6387	6387	A	G	MI.2905	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	484	162	I	V	Atc/Gtc	-11.44	0	0	probably_damaging	0.95	neutral	0.17	neutral	2.75	neutral	-0.34	neutral	-0.37	low_impact	0.8	0.57	damaging	0.22	damaging	1.10	11.24	neutral	0.51	0.6	0.26	neutral	0.23	neutral	0.33	neutral	0.4	neutral	2	0.97	neutral	0.11	neutral	-2	neutral	0.59	deleterious	-1.96	low_impact	-0.19	medium_impact	-0.36	medium_impact	0.70	0.9	0.97	6.72	0.4	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6388	6388	T	G	MI.2906	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	485	162	I	S	aTc/aGc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.03	deleterious	-4.9	high_impact	4.46	0.49	damaging	0.1	damaging	4.22	23.90	deleterious	0.24	0.55	0.85	disease	0.9	disease	0.59	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.62	0.9	0.97	6.72	0.48	N	0.62	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6388	6388	T	A	MI.2907	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	485	162	I	N	aTc/aAc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.28	deleterious	-5.77	high_impact	4.81	0.5	damaging	0.05	damaging	4.35	24.10	deleterious	0.2	0.55	0.92	disease	0.88	disease	0.58	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.34	high_impact	0.69	0.9	0.97	6.72	0.65	P	0.94	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6388	6388	T	C	MI.2908	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	485	162	I	T	aTc/aCc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.57	neutral	-2.18	deleterious	-3.79	medium_impact	3.46	0.49	damaging	0.06	damaging	3.35	22.90	deleterious	0.39	0.55	0.6	disease	0.81	disease	0.57	disease	0.67	disease	3	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.1	high_impact	0.71	0.9	0.97	6.72	0.43	N	0.76	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6389	6389	C	G	MI.2909	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	486	162	I	M	atC/atG	7.53	1	0	probably_damaging	1	neutral	0.05	neutral	2.54	neutral	-2.88	neutral	-2.27	medium_impact	3.06	0.54	damaging	0.07	damaging	3.24	22.80	deleterious	0.33	0.55	0.79	disease	0.64	disease	0.35	neutral	0.47	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.52	medium_impact	1.73	medium_impact	0.80	0.9	0.97	6.72	0.49	P	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8662	8662	C	A	MI.291	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	136	46	Q	K	Caa/Aaa	-9.82	0	0	probably_damaging	0.97	neutral	0.29	neutral	4.34	neutral	-1.56	deleterious	-3.74	low_impact	1.91	0.8	neutral	0.14	damaging	3.86	23.50	deleterious	0.38	0.65	0.75	disease	0.8	disease	0.48	neutral	0.59	disease	2	0.98	neutral	0.16	neutral	-2	neutral	0.82	deleterious	-2.19	low_impact	0.07	medium_impact	0.54	medium_impact	0.72	0.9	49.56	8.75	0.24	N	0.98	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6389	6389	C	A	MI.2910	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	486	162	I	M	atC/atA	7.53	1	0	probably_damaging	1	neutral	0.05	neutral	2.54	neutral	-2.88	neutral	-2.27	medium_impact	3.06	0.54	damaging	0.07	damaging	3.72	23.30	deleterious	0.33	0.55	0.79	disease	0.64	disease	0.35	neutral	0.47	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.52	medium_impact	1.73	medium_impact	0.80	0.9	0.97	6.72	0.49	P	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6390	6390	A	C	MI.2911	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	487	163	N	H	Aat/Cat	-2.65	0	0	possibly_damaging	0.87	deleterious	0	neutral	2.5	deleterious	-4.78	deleterious	-4.35	high_impact	5.32	0.61	neutral	0.1	damaging	3.00	22.20	deleterious	0.29	0.55	0.79	disease	0.91	disease	0.77	disease	0.72	disease	4	1	deleterious	0.07	neutral	5	deleterious	0.83	deleterious	-1.53	low_impact	-1.48	low_impact	3.81	high_impact	0.62	0.9	1.56	7.11	0.69	P	0.83	polymorphism	0.97	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6390	6390	A	T	MI.2912	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	487	163	N	Y	Aat/Tat	-2.65	0	0	probably_damaging	0.94	deleterious	0	neutral	2.51	deleterious	-4.03	deleterious	-6.96	high_impact	5.32	0.59	damaging	0.11	damaging	3.62	23.20	deleterious	0.2	0.55	0.85	disease	0.95	disease	0.73	disease	0.7	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.88	deleterious	-1.88	low_impact	-1.48	low_impact	3.81	high_impact	0.48	0.9	1.56	7.11	0.58	P	0.93	polymorphism	0.9	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6390	6390	A	G	MI.2913	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	487	163	N	D	Aat/Gat	-2.65	0	0	benign	0.21	deleterious	0	neutral	2.53	deleterious	-3.43	deleterious	-4.35	high_impact	5.32	0.47	damaging	0.16	damaging	3.77	23.40	deleterious	0.36	0.55	0.59	disease	0.89	disease	0.75	disease	0.73	disease	5	1	deleterious	0.4	neutral	2	deleterious	0.42	neutral	-0.22	medium_impact	-1.48	low_impact	3.81	high_impact	0.66	0.9	1.56	7.11	0.63	P	0.92	polymorphism	0.99	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6391	6391	A	C	MI.2914	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	488	163	N	T	aAt/aCt	8.69	1	0	benign	0.38	deleterious	0	neutral	2.53	deleterious	-3.6	deleterious	-5.22	high_impact	5.32	0.61	neutral	0.14	damaging	3.36	22.90	deleterious	0.29	0.55	0.67	disease	0.92	disease	0.69	disease	0.72	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.58	deleterious	-0.56	medium_impact	-1.48	low_impact	3.81	high_impact	0.62	0.9	1.56	7.11	0.65	P	0.59	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6391	6391	A	G	MI.2915	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	488	163	N	S	aAt/aGt	8.69	1	0	benign	0.09	deleterious	0	neutral	2.54	deleterious	-3.22	deleterious	-4.35	high_impact	5.32	0.63	neutral	0.12	damaging	3.05	22.40	deleterious	0.41	0.55	0.61	disease	0.91	disease	0.68	disease	0.72	disease	4	1	deleterious	0.46	neutral	2	deleterious	0.39	neutral	0.19	medium_impact	-1.48	low_impact	3.81	high_impact	0.62	0.9	1.56	7.11	0.67	P	0.79	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6391	6391	A	T	MI.2916	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	488	163	N	I	aAt/aTt	8.69	1	0	possibly_damaging	0.89	deleterious	0	neutral	2.56	neutral	-2.76	deleterious	-7.83	high_impact	5.32	0.52	damaging	0.13	damaging	4.08	23.70	deleterious	0.21	0.55	0.39	neutral	0.96	disease	0.69	disease	0.78	disease	6	1	deleterious	0.06	neutral	5	deleterious	0.80	deleterious	-1.61	low_impact	-1.48	low_impact	3.81	high_impact	0.44	0.9	1.56	7.11	0.61	P	0.98	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6392	6392	T	G	MI.2917	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	489	163	N	K	aaT/aaG	8.69	1	0.16	benign	0.03	deleterious	0	neutral	2.51	deleterious	-4.07	deleterious	-5.22	high_impact	4.97	0.54	damaging	0.1	damaging	3.96	23.60	deleterious	0.32	0.55	0.56	disease	0.94	disease	0.77	disease	0.83	disease	7	1	deleterious	0.49	deleterious	2	deleterious	0.36	neutral	0.66	medium_impact	-1.48	low_impact	3.49	high_impact	0.66	0.9	1.56	7.11	0.66	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6392	6392	T	A	MI.2918	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	489	163	N	K	aaT/aaA	8.69	1	0.16	benign	0.03	deleterious	0	neutral	2.51	deleterious	-4.07	deleterious	-5.22	high_impact	4.97	0.54	damaging	0.1	damaging	4.30	24.00	deleterious	0.32	0.55	0.56	disease	0.94	disease	0.77	disease	0.83	disease	7	1	deleterious	0.49	deleterious	2	deleterious	0.36	neutral	0.66	medium_impact	-1.48	low_impact	3.49	high_impact	0.66	0.9	1.56	7.11	0.66	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6393	6393	T	C	MI.2919	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	490	164	F	L	Ttc/Ctc	-3.57	0	0	probably_damaging	1	deleterious	0.01	neutral	2.74	neutral	-0.35	deleterious	-5.2	high_impact	3.72	0.8	neutral	0.03	damaging	4.12	23.80	deleterious	0.4	0.55	0.34	neutral	0.75	disease	0.49	neutral	0.35	neutral	3	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	2.34	high_impact	0.71	0.9	2.92	8.17	0.28	N	0.83	polymorphism	0.95	0.23	rs879212050	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8663	8663	A	C	MI.292	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	137	46	Q	P	cAa/cCa	4.52	1	0	probably_damaging	0.98	neutral	0.2	neutral	4.33	neutral	-2.27	deleterious	-5.62	medium_impact	3.06	0.76	neutral	0.15	damaging	3.15	22.60	deleterious	0.19	0.65	0.85	disease	0.9	disease	0.64	disease	0.78	disease	6	0.99	deleterious	0.11	neutral	1	deleterious	0.89	deleterious	-2.36	low_impact	-0.05	medium_impact	1.53	medium_impact	0.70	0.9	49.56	8.75	0.4	N	0.97	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6393	6393	T	A	MI.2920	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	490	164	F	I	Ttc/Atc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-0.68	deleterious	-5.2	high_impact	3.88	0.7	neutral	0.05	damaging	4.57	24.40	deleterious	0.23	0.55	0.58	disease	0.84	disease	0.6	disease	0.6	disease	2	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.48	high_impact	0.64	0.9	2.92	8.17	0.28	N	0.88	polymorphism	0.96	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6393	6393	T	G	MI.2921	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	490	164	F	V	Ttc/Gtc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.66	neutral	-0.94	deleterious	-6.07	high_impact	4.46	0.67	neutral	0.04	damaging	4.13	23.80	deleterious	0.24	0.55	0.56	disease	0.88	disease	0.66	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.63	0.9	2.92	8.17	0.39	N	0.84	polymorphism	0.91	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6394	6394	T	A	MI.2922	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	491	164	F	Y	tTc/tAc	5.91	1	0	probably_damaging	1	deleterious	0.04	neutral	2.51	deleterious	-3.1	deleterious	-2.6	high_impact	4.17	0.66	neutral	0.04	damaging	4.11	23.80	deleterious	0.28	0.55	0.63	disease	0.79	disease	0.61	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-0.58	medium_impact	2.75	high_impact	0.73	0.9	2.92	8.17	0.57	P	0.59	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6394	6394	T	G	MI.2923	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	491	164	F	C	tTc/tGc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.47	deleterious	-6.95	high_impact	5.26	0.66	neutral	0.03	damaging	4.03	23.60	deleterious	0.2	0.55	0.86	disease	0.86	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.49	0.9	2.92	8.17	0.66	P	0.91	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6394	6394	T	C	MI.2924	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	491	164	F	S	tTc/tCc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.46	deleterious	-6.94	high_impact	4.57	0.7	neutral	0.05	damaging	4.19	23.80	deleterious	0.22	0.55	0.73	disease	0.87	disease	0.65	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.58	0.9	2.92	8.17	0.56	P	0.84	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6395	6395	C	A	MI.2925	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	492	164	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.74	neutral	-0.35	deleterious	-5.2	high_impact	3.72	0.8	neutral	0.03	damaging	4.63	24.50	deleterious	0.4	0.55	0.34	neutral	0.75	disease	0.49	neutral	0.35	neutral	3	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	2.34	high_impact	0.71	0.9	2.92	8.17	0.47	N	0.83	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6395	6395	C	G	MI.2926	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	492	164	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.74	neutral	-0.35	deleterious	-5.2	high_impact	3.72	0.8	neutral	0.03	damaging	4.29	24.00	deleterious	0.4	0.55	0.34	neutral	0.75	disease	0.49	neutral	0.35	neutral	3	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	2.34	high_impact	0.71	0.9	2.92	8.17	0.47	N	0.83	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6396	6396	A	T	MI.2927	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	493	165	I	F	Atc/Ttc	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2	deleterious	-3.33	high_impact	4.42	0.56	damaging	0.04	damaging	3.68	23.30	deleterious	0.32	0.55	0.75	disease	0.83	disease	0.61	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.81	0.9	2.73	6.7	0.36	N	0.85	disease_causing	0.97	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6396	6396	A	G	MI.2928	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	493	165	I	V	Atc/Gtc	-3.11	0	0	probably_damaging	0.95	deleterious	0.04	neutral	2.77	neutral	-0.74	neutral	-0.83	medium_impact	3.1	0.58	damaging	0.07	damaging	2.97	22.10	deleterious	0.59	0.65	0.39	neutral	0.5	disease	0.52	disease	0.46	neutral	1	0.99	deleterious	0.05	neutral	5	deleterious	0.66	deleterious	-1.96	low_impact	-0.58	medium_impact	1.76	medium_impact	0.68	0.9	2.73	6.7	0.35	N	0.23	polymorphism	0.85	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6396	6396	A	C	MI.2929	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	493	165	I	L	Atc/Ctc	-3.11	0	0	probably_damaging	0.98	neutral	0.09	neutral	2.81	neutral	-0.75	neutral	-1.56	medium_impact	2.34	0.63	neutral	0.05	damaging	3.73	23.30	deleterious	0.35	0.55	0.27	neutral	0.63	disease	0.37	neutral	0.2	neutral	6	0.99	deleterious	0.06	neutral	1	deleterious	0.65	deleterious	-2.35	low_impact	-0.37	medium_impact	1.06	medium_impact	0.77	0.9	2.73	6.7	0.3	N	0.61	polymorphism	0.71	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8663	8663	A	G	MI.293	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	137	46	Q	R	cAa/cGa	4.52	1	0	probably_damaging	0.97	neutral	0.35	neutral	4.36	neutral	-0.65	deleterious	-3.74	medium_impact	2.71	0.89	neutral	0.15	damaging	3.35	22.90	deleterious	0.49	0.65	0.78	disease	0.79	disease	0.63	disease	0.66	disease	3	0.97	neutral	0.19	neutral	1	deleterious	0.83	deleterious	-2.19	low_impact	0.14	medium_impact	1.23	medium_impact	0.66	0.9	49.56	8.75	0.47	N	0.87	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6397	6397	T	A	MI.2930	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	494	165	I	N	aTc/aAc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.39	deleterious	-5.91	high_impact	5.11	0.53	damaging	0.05	damaging	4.38	24.10	deleterious	0.3	0.55	0.92	disease	0.83	disease	0.61	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.71	0.9	2.73	6.7	0.63	P	0.94	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6397	6397	T	G	MI.2931	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	494	165	I	S	aTc/aGc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-3.16	deleterious	-5.03	high_impact	4.76	0.59	damaging	0.07	damaging	4.23	23.90	deleterious	0.27	0.55	0.84	disease	0.86	disease	0.59	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.63	0.9	2.73	6.7	0.67	P	0.62	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6397	6397	T	C	MI.2932	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	494	165	I	T	aTc/aCc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-2.68	deleterious	-4.2	high_impact	4.21	0.57	damaging	0.05	damaging	3.37	22.90	deleterious	0.46	0.55	0.77	disease	0.79	disease	0.58	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.79	high_impact	0.74	0.9	2.73	6.7	0.45	N	0.76	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6398	6398	C	G	MI.2933	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	495	165	I	M	atC/atG	7.53	1	0	probably_damaging	1	neutral	0.23	neutral	2.62	neutral	-2.69	neutral	-2.29	medium_impact	2.3	0.51	damaging	0.1	damaging	3.17	22.70	deleterious	0.47	0.55	0.54	disease	0.6	disease	0.38	neutral	0.22	neutral	6	1	deleterious	0.12	neutral	1	deleterious	0.74	deleterious	-3.58	low_impact	-0.1	medium_impact	1.03	medium_impact	0.90	0.95	2.73	6.7	0.5	P	0.76	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6398	6398	C	A	MI.2934	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	495	165	I	M	atC/atA	7.53	1	0	probably_damaging	1	neutral	0.23	neutral	2.62	neutral	-2.69	neutral	-2.29	medium_impact	2.3	0.51	damaging	0.1	damaging	3.61	23.20	deleterious	0.47	0.55	0.54	disease	0.6	disease	0.38	neutral	0.22	neutral	6	1	deleterious	0.12	neutral	1	deleterious	0.74	deleterious	-3.58	low_impact	-0.1	medium_impact	1.03	medium_impact	0.90	0.95	2.73	6.7	0.51	P	0.76	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6399	6399	A	C	MI.2935	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	496	166	T	P	Aca/Cca	-1.26	0.01	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-3.41	deleterious	-4	high_impact	4.65	0.62	neutral	0.13	damaging	3.41	23.00	deleterious	0.12	0.55	0.67	disease	0.88	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.67	0.9	2.53	7.17	0.5	N	0.92	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6399	6399	A	G	MI.2936	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	496	166	T	A	Aca/Gca	-1.26	0.01	0	probably_damaging	0.98	deleterious	0.01	neutral	2.85	neutral	-0.65	deleterious	-2.74	medium_impact	2.44	0.62	neutral	0.17	damaging	3.35	22.90	deleterious	0.53	0.6	0.23	neutral	0.55	disease	0.39	neutral	0.21	neutral	6	1	deleterious	0.02	neutral	5	deleterious	0.68	deleterious	-2.35	low_impact	-0.92	medium_impact	1.15	medium_impact	0.69	0.9	2.53	7.17	0.33	N	0.69	disease_causing	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6399	6399	A	T	MI.2937	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	496	166	T	S	Aca/Tca	-1.26	0.01	0	probably_damaging	0.98	neutral	0.09	neutral	2.79	neutral	-1.72	neutral	-1.57	neutral_impact	0.61	0.52	damaging	0.27	damaging	1.81	15.03	deleterious	0.42	0.55	0.35	neutral	0.29	neutral	0.31	neutral	0.44	neutral	1	0.99	deleterious	0.06	neutral	-2	neutral	0.69	deleterious	-2.35	low_impact	-0.37	medium_impact	-0.54	medium_impact	0.77	0.9	2.53	7.17	0.42	N	0.79	disease_causing	0.93	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6400	6400	C	T	MI.2938	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	497	166	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-2.77	deleterious	-3.9	high_impact	4.65	0.74	neutral	0.12	damaging	3.96	23.60	deleterious	0.27	0.55	0.45	neutral	0.77	disease	0.58	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.87	0.9	2.53	7.17	0.51	P	0.96	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6400	6400	C	A	MI.2939	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	497	166	T	K	aCa/aAa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-2.25	deleterious	-3.75	high_impact	4.65	0.65	neutral	0.11	damaging	4.40	24.10	deleterious	0.13	0.55	0.56	disease	0.9	disease	0.67	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.76	0.9	2.53	7.17	0.56	P	0.88	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8663	8663	A	T	MI.294	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	137	46	Q	L	cAa/cTa	4.52	1	0	probably_damaging	0.97	neutral	0.65	neutral	4.58	neutral	1.81	deleterious	-6.54	low_impact	0.84	0.9	neutral	0.15	damaging	3.67	23.20	deleterious	0.21	0.65	0.34	neutral	0.78	disease	0.35	neutral	0.53	disease	1	0.97	neutral	0.34	neutral	-2	neutral	0.75	deleterious	-2.19	low_impact	0.44	medium_impact	-0.38	medium_impact	0.33	0.9	49.56	8.75	0.35	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6402	6402	A	G	MI.2940	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	499	167	T	A	Aca/Gca	-11.44	0	0	probably_damaging	0.98	deleterious	0	neutral	1.92	deleterious	-3.7	deleterious	-4.33	high_impact	4.94	0.73	neutral	0.08	damaging	3.41	23.00	deleterious	0.39	0.55	0.59	disease	0.61	disease	0.67	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.35	low_impact	-1.48	low_impact	3.46	high_impact	0.62	0.9	2.34	6.67	0.6	P	0.69	polymorphism	0.97	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6402	6402	A	C	MI.2941	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	499	167	T	P	Aca/Cca	-11.44	0	0	probably_damaging	1	deleterious	0	neutral	1.83	deleterious	-6.38	deleterious	-5.21	high_impact	5.29	0.57	damaging	0.08	damaging	3.40	23.00	deleterious	0.16	0.55	0.85	disease	0.82	disease	0.79	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.67	0.9	2.34	6.67	0.59	P	0.92	polymorphism	0.87	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6402	6402	A	T	MI.2942	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	499	167	T	S	Aca/Tca	-11.44	0	0	probably_damaging	0.98	deleterious	0	neutral	1.89	deleterious	-4.17	deleterious	-3.46	medium_impact	3.17	0.68	neutral	0.09	damaging	3.28	22.80	deleterious	0.34	0.55	0.64	disease	0.7	disease	0.61	disease	0.56	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-2.35	low_impact	-1.48	low_impact	1.83	medium_impact	0.73	0.9	2.34	6.67	0.24	N	0.79	polymorphism	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6403	6403	C	A	MI.2943	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	500	167	T	K	aCa/aAa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	1.86	deleterious	-4.96	deleterious	-5.21	high_impact	5.29	0.64	neutral	0.06	damaging	4.43	24.20	deleterious	0.19	0.55	0.78	disease	0.9	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.77	0.9	2.34	6.67	0.73	P	0.88	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6403	6403	C	T	MI.2944	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	500	167	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	1.83	deleterious	-6.31	deleterious	-5.21	high_impact	5.29	0.7	neutral	0.07	damaging	3.89	23.50	deleterious	0.35	0.55	0.38	neutral	0.82	disease	0.69	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.78	0.9	2.34	6.67	0.62	P	0.96	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6405	6405	A	T	MI.2945	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	502	168	I	F	Att/Ttt	-5.19	0	0	possibly_damaging	0.68	neutral	0.08	neutral	2.44	deleterious	-3.14	deleterious	-2.99	medium_impact	3.34	0.66	neutral	0.1	damaging	3.98	23.60	deleterious	0.34	0.55	0.54	disease	0.81	disease	0.48	neutral	0.6	disease	2	0.93	neutral	0.2	neutral	0	NA	0.67	deleterious	-1.06	low_impact	-0.4	medium_impact	1.99	medium_impact	0.80	0.9	5.85	15.28	0.28	N	0.85	polymorphism	0.98	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6405	6405	A	C	MI.2946	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	502	168	I	L	Att/Ctt	-5.19	0	0	benign	0.12	deleterious	0.03	neutral	2.64	neutral	-0.83	neutral	-1.32	medium_impact	2.99	0.66	neutral	0.12	damaging	3.65	23.20	deleterious	0.38	0.55	0.35	neutral	0.69	disease	0.5	neutral	0.47	neutral	1	0.97	neutral	0.46	neutral	1	deleterious	0.19	neutral	0.06	medium_impact	-0.65	medium_impact	1.66	medium_impact	0.79	0.9	5.85	15.28	0.31	N	0.61	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6405	6405	A	G	MI.2947	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	502	168	I	V	Att/Gtt	-5.19	0	0	benign	0	neutral	0.19	neutral	2.63	neutral	-0.85	neutral	-0.26	low_impact	1.21	0.66	neutral	0.27	damaging	1.04	10.91	neutral	0.61	0.65	0.25	neutral	0.21	neutral	0.32	neutral	0.36	neutral	3	0.81	neutral	0.6	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	-0.16	medium_impact	0.02	medium_impact	0.71	0.9	5.85	15.28	0.48	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6406	6406	T	G	MI.2948	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	503	168	I	S	aTt/aGt	3.14	0.75	0	possibly_damaging	0.87	neutral	0.11	neutral	2.42	deleterious	-3.52	deleterious	-4.09	medium_impact	3.15	0.68	neutral	0.24	damaging	4.12	23.80	deleterious	0.28	0.55	0.54	disease	0.85	disease	0.53	disease	0.63	disease	3	0.95	neutral	0.12	neutral	0	NA	0.69	deleterious	-1.53	low_impact	-0.31	medium_impact	1.81	medium_impact	0.71	0.9	5.85	15.28	0.35	N	0.62	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6406	6406	T	C	MI.2949	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	503	168	I	T	aTt/aCt	3.14	0.75	0	possibly_damaging	0.66	neutral	0.29	neutral	2.44	neutral	-2.91	deleterious	-3.15	medium_impact	2.56	0.66	neutral	0.27	damaging	2.23	17.73	deleterious	0.39	0.55	0.33	neutral	0.71	disease	0.35	neutral	0.49	neutral	0	0.76	neutral	0.32	neutral	0	NA	0.45	deleterious	-1.03	low_impact	-0.02	medium_impact	1.27	medium_impact	0.75	0.9	5.85	15.28	0.35	N	0.76	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8664	8664	A	C	MI.295	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	138	46	Q	H	caA/caC	6.84	1	0	probably_damaging	1	neutral	0.54	neutral	4.33	neutral	-2.21	deleterious	-4.67	medium_impact	3.27	0.82	neutral	0.13	damaging	3.32	22.90	deleterious	0.54	0.65	0.84	disease	0.74	disease	0.47	neutral	0.61	disease	2	0.99	deleterious	0.27	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.33	medium_impact	1.71	medium_impact	0.78	0.9	49.56	8.75	0.46	N	0.95	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6406	6406	T	A	MI.2950	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	503	168	I	N	aTt/aAt	3.14	0.75	0	probably_damaging	0.97	deleterious	0	neutral	2.41	deleterious	-4.25	deleterious	-5.05	high_impact	3.75	0.65	neutral	0.12	damaging	4.44	24.20	deleterious	0.3	0.55	0.71	disease	0.85	disease	0.55	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-2.18	low_impact	-1.48	low_impact	2.36	high_impact	0.77	0.9	5.85	15.28	0.37	N	0.94	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6407	6407	T	A	MI.2951	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	504	168	I	M	atT/atA	1.98	0.74	0	possibly_damaging	0.87	deleterious	0.02	neutral	2.46	neutral	-2.52	neutral	-1.6	medium_impact	2.48	0.69	neutral	0.2	damaging	2.61	20.30	deleterious	0.51	0.6	0.5	neutral	0.58	disease	0.33	neutral	0.46	neutral	1	0.99	deleterious	0.08	neutral	4	deleterious	0.56	deleterious	-1.53	low_impact	-0.75	medium_impact	1.19	medium_impact	0.86	0.9	5.85	15.28	0.33	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6407	6407	T	G	MI.2952	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	504	168	I	M	atT/atG	1.98	0.74	0	possibly_damaging	0.87	deleterious	0.02	neutral	2.46	neutral	-2.52	neutral	-1.6	medium_impact	2.48	0.69	neutral	0.2	damaging	2.28	18.06	deleterious	0.51	0.6	0.5	neutral	0.58	disease	0.33	neutral	0.46	neutral	1	0.99	deleterious	0.08	neutral	4	deleterious	0.56	deleterious	-1.53	low_impact	-0.75	medium_impact	1.19	medium_impact	0.86	0.9	5.85	15.28	0.33	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6408	6408	A	C	MI.2953	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	505	169	I	L	Atc/Ctc	-5.89	0	0	benign	0.02	neutral	0.25	neutral	2.97	neutral	0.81	neutral	-0.87	neutral_impact	0.71	0.67	neutral	0.28	neutral	0.73	9.05	deleterious	0.37	0.55	0.17	neutral	0.4	neutral	0.25	neutral	0.45	neutral	1	0.74	neutral	0.62	deleterious	-6	neutral	0.12	neutral	0.83	medium_impact	-0.07	medium_impact	-0.44	medium_impact	0.68	0.9	6.24	8.75	0.4	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6408	6408	A	T	MI.2954	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	505	169	I	F	Atc/Ttc	-5.89	0	0	benign	0.24	neutral	0.17	neutral	2.77	neutral	-0.66	neutral	-2.21	low_impact	1.56	0.63	neutral	0.14	damaging	0.94	10.33	neutral	0.39	0.55	0.39	neutral	0.55	disease	0.26	neutral	0.36	neutral	3	0.8	neutral	0.47	neutral	-6	neutral	0.35	neutral	-0.29	medium_impact	-0.19	medium_impact	0.34	medium_impact	0.71	0.9	6.24	8.75	0.37	N	0.85	polymorphism	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6408	6408	A	G	MI.2955	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	505	169	I	V	Atc/Gtc	-5.89	0	0	benign	0	deleterious	0.04	neutral	2.86	neutral	0.11	neutral	-0.66	low_impact	1.8	0.69	neutral	0.62	neutral	1.04	10.89	neutral	0.61	0.65	0.25	neutral	0.43	neutral	0.43	neutral	0.44	neutral	1	0.96	neutral	0.52	deleterious	-2	neutral	0.13	neutral	2.07	high_impact	-0.58	medium_impact	0.56	medium_impact	0.62	0.9	6.24	8.75	0.51	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6409	6409	T	C	MI.2956	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	506	169	I	T	aTc/aCc	5.45	1	0	benign	0.22	neutral	0.05	neutral	2.76	neutral	-1.58	deleterious	-3.32	medium_impact	3.13	0.64	neutral	0.18	damaging	1.63	14.02	neutral	0.45	0.55	0.41	neutral	0.73	disease	0.53	disease	0.58	disease	2	0.94	neutral	0.42	neutral	-3	neutral	0.27	neutral	-0.24	medium_impact	-0.52	medium_impact	1.79	medium_impact	0.59	0.9	6.24	8.75	0.52	P	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6409	6409	T	A	MI.2957	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	506	169	I	N	aTc/aAc	5.45	1	0	possibly_damaging	0.81	neutral	0.11	neutral	2.68	deleterious	-3.25	deleterious	-4.81	medium_impact	3.4	0.61	neutral	0.13	damaging	4.17	23.80	deleterious	0.34	0.55	0.47	neutral	0.81	disease	0.43	neutral	0.62	disease	2	0.93	neutral	0.15	neutral	0	NA	0.68	deleterious	-1.35	low_impact	-0.31	medium_impact	2.04	high_impact	0.70	0.9	6.24	8.75	0.49	P	0.94	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6409	6409	T	G	MI.2958	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	506	169	I	S	aTc/aGc	5.45	1	0	possibly_damaging	0.49	deleterious	0.02	neutral	2.72	neutral	-2	deleterious	-3.96	medium_impact	2.99	0.66	neutral	0.16	damaging	3.76	23.40	deleterious	0.36	0.55	0.42	neutral	0.81	disease	0.46	neutral	0.53	disease	1	0.98	neutral	0.27	neutral	4	deleterious	0.40	neutral	-0.74	medium_impact	-0.75	medium_impact	1.66	medium_impact	0.60	0.9	6.24	8.75	0.45	N	0.62	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6410	6410	C	G	MI.2959	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	507	169	I	M	atC/atG	7.53	1	0.03	possibly_damaging	0.49	neutral	0.13	neutral	2.72	neutral	-1.92	neutral	-1.3	low_impact	1.12	0.63	neutral	0.22	damaging	1.71	14.47	neutral	0.49	0.55	0.49	neutral	0.44	neutral	0.28	neutral	0.42	neutral	2	0.86	neutral	0.32	neutral	-3	neutral	0.29	neutral	-0.74	medium_impact	-0.27	medium_impact	-0.07	medium_impact	0.73	0.9	6.24	8.75	0.53	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8664	8664	A	T	MI.296	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	138	46	Q	H	caA/caT	6.84	1	0	probably_damaging	1	neutral	0.54	neutral	4.33	neutral	-2.21	deleterious	-4.67	medium_impact	3.27	0.82	neutral	0.13	damaging	3.52	23.10	deleterious	0.54	0.65	0.84	disease	0.74	disease	0.47	neutral	0.61	disease	2	0.99	deleterious	0.27	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.33	medium_impact	1.71	medium_impact	0.78	0.9	49.56	8.75	0.47	N	0.95	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6410	6410	C	A	MI.2960	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	507	169	I	M	atC/atA	7.53	1	0.03	possibly_damaging	0.49	neutral	0.13	neutral	2.72	neutral	-1.92	neutral	-1.3	low_impact	1.12	0.63	neutral	0.22	damaging	2.19	17.47	deleterious	0.49	0.55	0.49	neutral	0.44	neutral	0.28	neutral	0.42	neutral	2	0.86	neutral	0.32	neutral	-3	neutral	0.29	neutral	-0.74	medium_impact	-0.27	medium_impact	-0.07	medium_impact	0.73	0.9	6.24	8.75	0.53	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6411	6411	A	T	MI.2961	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	508	170	N	Y	Aat/Tat	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.44	deleterious	-6.87	high_impact	4.23	0.57	damaging	0.13	damaging	3.66	23.20	deleterious	0.36	0.55	0.67	disease	0.89	disease	0.6	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.81	high_impact	0.43	0.9	3.31	6.84	0.32	N	0.93	polymorphism	0.95	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6411	6411	A	C	MI.2962	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	508	170	N	H	Aat/Cat	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-2.07	deleterious	-4.3	high_impact	4.03	0.57	damaging	0.12	damaging	3.01	22.30	deleterious	0.53	0.6	0.48	neutral	0.81	disease	0.61	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.62	high_impact	0.48	0.9	3.31	6.84	0.28	N	0.83	polymorphism	0.99	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6411	6411	A	G	MI.2963	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	508	170	N	D	Aat/Gat	-5.42	0	0	probably_damaging	0.99	deleterious	0	neutral	2.69	neutral	-1.68	deleterious	-4.31	high_impact	4.78	0.55	damaging	0.14	damaging	3.81	23.40	deleterious	0.63	0.65	0.43	neutral	0.78	disease	0.61	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.64	low_impact	-1.48	low_impact	3.32	high_impact	0.48	0.9	3.31	6.84	0.59	P	0.92	polymorphism	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6412	6412	A	T	MI.2964	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	509	170	N	I	aAt/aTt	7.07	1	0	probably_damaging	1	deleterious	0.03	neutral	2.66	deleterious	-3.11	deleterious	-7.72	high_impact	4.23	0.58	damaging	0.12	damaging	3.96	23.60	deleterious	0.38	0.55	0.6	disease	0.92	disease	0.59	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-0.65	medium_impact	2.81	high_impact	0.32	0.9	3.31	6.84	0.47	N	0.98	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6412	6412	A	C	MI.2965	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	509	170	N	T	aAt/aCt	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-1.23	deleterious	-5.15	medium_impact	3.38	0.59	damaging	0.13	damaging	3.40	23.00	deleterious	0.51	0.6	0.27	neutral	0.87	disease	0.57	disease	0.67	disease	3	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.02	high_impact	0.51	0.9	3.31	6.84	0.43	N	0.59	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6412	6412	A	G	MI.2966	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	509	170	N	S	aAt/aGt	7.07	1	0	probably_damaging	0.98	neutral	0.06	neutral	2.74	neutral	-0.79	deleterious	-4.29	high_impact	3.56	0.52	damaging	0.16	damaging	3.07	22.40	deleterious	0.68	0.7	0.36	neutral	0.81	disease	0.57	disease	0.56	disease	1	1	deleterious	0.04	neutral	2	deleterious	0.78	deleterious	-2.35	low_impact	-0.47	medium_impact	2.19	high_impact	0.33	0.9	3.31	6.84	0.51	P	0.79	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6413	6413	T	G	MI.2967	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	510	170	N	K	aaT/aaG	8.69	1	0.05	probably_damaging	1	deleterious	0	neutral	2.94	neutral	0.9	deleterious	-5.15	medium_impact	3.34	0.53	damaging	0.12	damaging	3.95	23.60	deleterious	0.59	0.65	0.21	neutral	0.88	disease	0.56	disease	0.65	disease	3	1	deleterious	0	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	1.99	medium_impact	0.51	0.9	3.31	6.84	0.46	N	0.92	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6413	6413	T	A	MI.2968	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	510	170	N	K	aaT/aaA	8.69	1	0.05	probably_damaging	1	deleterious	0	neutral	2.94	neutral	0.9	deleterious	-5.15	medium_impact	3.34	0.53	damaging	0.12	damaging	4.27	24.00	deleterious	0.59	0.65	0.21	neutral	0.88	disease	0.56	disease	0.65	disease	3	1	deleterious	0	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	1.99	medium_impact	0.51	0.9	3.31	6.84	0.49	P	0.92	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6414	6414	A	C	MI.2969	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	511	171	M	L	Ata/Cta	-5.42	0	0	probably_damaging	0.95	neutral	0.09	neutral	2.86	neutral	-1.04	deleterious	-2.5	low_impact	1.9	0.65	neutral	0.07	damaging	3.08	22.50	deleterious	0.53	0.6	0.23	neutral	0.73	disease	0.45	neutral	0.2	neutral	6	0.98	deleterious	0.07	neutral	-2	neutral	0.70	deleterious	-1.96	low_impact	-0.37	medium_impact	0.66	medium_impact	0.59	0.9	3.51	6.93	0.24	N	0.61	polymorphism	0.56	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8665	8665	C	G	MI.297	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	139	47	Q	E	Caa/Gaa	0.59	0.06	0	benign	0.11	neutral	0.91	neutral	4.67	neutral	1.9	neutral	-1.52	neutral_impact	-1.16	0.87	neutral	0.59	neutral	-1.24	0.01	neutral	0.61	0.7	0.51	disease	0.32	neutral	0.37	neutral	0.26	neutral	5	0.03	neutral	0.9	deleterious	-6	neutral	0.23	neutral	0.11	medium_impact	0.86	medium_impact	-2.09	low_impact	0.71	0.9	22.12	21.76	0.26	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6414	6414	A	G	MI.2970	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	511	171	M	V	Ata/Gta	-5.42	0	0	probably_damaging	0.97	neutral	0.05	neutral	2.81	neutral	-1.85	deleterious	-3.39	high_impact	3.9	0.59	damaging	0.07	damaging	2.61	20.30	deleterious	0.54	0.6	0.56	disease	0.81	disease	0.72	disease	0.7	disease	4	0.99	deleterious	0.04	neutral	2	deleterious	0.82	deleterious	-2.18	low_impact	-0.52	medium_impact	2.5	high_impact	0.57	0.9	3.51	6.93	0.29	N	0.88	polymorphism	0.51	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6414	6414	A	T	MI.2971	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	511	171	M	L	Ata/Tta	-5.42	0	0	probably_damaging	0.95	neutral	0.09	neutral	2.86	neutral	-1.04	deleterious	-2.5	low_impact	1.9	0.65	neutral	0.07	damaging	3.16	22.60	deleterious	0.53	0.6	0.23	neutral	0.73	disease	0.45	neutral	0.2	neutral	6	0.98	deleterious	0.07	neutral	-2	neutral	0.70	deleterious	-1.96	low_impact	-0.37	medium_impact	0.66	medium_impact	0.59	0.9	3.51	6.93	0.24	N	0.61	polymorphism	0.56	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6415	6415	T	A	MI.2972	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	512	171	M	K	aTa/aAa	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.76	deleterious	-3.08	deleterious	-5.13	high_impact	5.09	0.57	damaging	0.05	damaging	3.87	23.50	deleterious	0.21	0.55	0.89	disease	0.89	disease	0.78	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-2.64	low_impact	-1.48	low_impact	3.6	high_impact	0.38	0.9	3.51	6.93	0.73	P	0.93	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6415	6415	T	C	MI.2973	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	512	171	M	T	aTa/aCa	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.83	neutral	-1.45	deleterious	-5.1	high_impact	4.4	0.61	neutral	0.11	damaging	2.94	22.00	deleterious	0.49	0.55	0.78	disease	0.87	disease	0.71	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.64	low_impact	-1.48	low_impact	2.96	high_impact	0.38	0.9	3.51	6.93	0.5	P	0.79	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6416	6416	A	C	MI.2974	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	513	171	M	I	atA/atC	5.91	1	0	probably_damaging	0.98	deleterious	0	neutral	2.79	neutral	-2.22	deleterious	-3.38	high_impact	4.12	0.53	damaging	0.1	damaging	3.27	22.80	deleterious	0.54	0.6	0.53	disease	0.81	disease	0.62	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.35	low_impact	-1.48	low_impact	2.71	high_impact	0.66	0.9	3.51	6.93	0.49	P	0.87	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6416	6416	A	T	MI.2975	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	513	171	M	I	atA/atT	5.91	1	0	probably_damaging	0.98	deleterious	0	neutral	2.79	neutral	-2.22	deleterious	-3.38	high_impact	4.12	0.53	damaging	0.1	damaging	3.35	22.90	deleterious	0.54	0.6	0.53	disease	0.81	disease	0.62	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.35	low_impact	-1.48	low_impact	2.71	high_impact	0.66	0.9	3.51	6.93	0.52	P	0.87	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6417	6417	A	G	MI.2976	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	514	172	K	E	Aaa/Gaa	-0.1	0.1	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.37	neutral	-1.89	medium_impact	3.42	0.53	damaging	0.08	damaging	4.00	23.60	deleterious	0.43	0.55	0.37	neutral	0.75	disease	0.55	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.06	high_impact	0.72	0.9	2.92	6.73	0.34	N	0.75	disease_causing	0.86	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6417	6417	A	C	MI.2977	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	514	172	K	Q	Aaa/Caa	-0.1	0.1	0	probably_damaging	1	deleterious	0.01	neutral	2.55	neutral	-2.24	neutral	-1.19	medium_impact	2.73	0.54	damaging	0.07	damaging	3.38	22.90	deleterious	0.38	0.55	0.43	neutral	0.51	disease	0.5	neutral	0.5	neutral	0	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	1.42	medium_impact	0.63	0.9	2.92	6.73	0.33	N	0.64	disease_causing	0.79	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6418	6418	A	C	MI.2978	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	515	172	K	T	aAa/aCa	8.69	1	0	probably_damaging	1	deleterious	0.02	neutral	2.54	neutral	-2.43	deleterious	-2.82	medium_impact	3.08	0.52	damaging	0.07	damaging	3.53	23.10	deleterious	0.32	0.55	0.49	neutral	0.58	disease	0.49	neutral	0.49	neutral	0	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-0.75	medium_impact	1.75	medium_impact	0.46	0.9	2.92	6.73	0.47	P	0.76	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6418	6418	A	T	MI.2979	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	515	172	K	M	aAa/aTa	8.69	1	0	probably_damaging	1	deleterious	0.01	neutral	2.48	deleterious	-4.83	deleterious	-2.71	medium_impact	2.27	0.56	damaging	0.06	damaging	3.77	23.40	deleterious	0.28	0.55	0.75	disease	0.56	disease	0.37	neutral	0.5	neutral	0	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-0.92	medium_impact	1	medium_impact	0.48	0.9	2.92	6.73	0.45	P	0.89	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8665	8665	C	A	MI.298	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	139	47	Q	K	Caa/Aaa	0.59	0.06	0	benign	0.04	neutral	1	neutral	4.41	neutral	0.18	neutral	-1.78	neutral_impact	-0.7	0.83	neutral	0.44	neutral	-0.18	1.23	neutral	0.63	0.7	0.31	neutral	0.33	neutral	0.21	neutral	0.44	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.21	neutral	0.55	medium_impact	1.98	high_impact	-1.7	low_impact	0.67	0.9	22.12	21.76	0.24	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6419	6419	A	C	MI.2980	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	516	172	K	N	aaA/aaC	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-2.89	neutral	-2	medium_impact	2.19	0.53	damaging	0.06	damaging	3.78	23.40	deleterious	0.53	0.6	0.48	neutral	0.61	disease	0.38	neutral	0.47	neutral	1	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	0.92	medium_impact	0.57	0.9	2.92	6.73	0.48	P	0.76	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6419	6419	A	T	MI.2981	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	516	172	K	N	aaA/aaT	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-2.89	neutral	-2	medium_impact	2.19	0.53	damaging	0.06	damaging	3.85	23.40	deleterious	0.53	0.6	0.48	neutral	0.61	disease	0.38	neutral	0.47	neutral	1	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	0.92	medium_impact	0.57	0.9	2.92	6.73	0.5	P	0.76	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6420	6420	C	G	MI.2982	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	517	173	P	A	Ccc/Gcc	1.75	1	0	probably_damaging	1	neutral	0.27	neutral	3	neutral	2.11	neutral	-0.64	neutral_impact	0.2	0.68	neutral	0.24	damaging	1.59	13.78	neutral	0.33	0.55	0.2	neutral	0.1	neutral	0.11	neutral	0.27	neutral	5	1	deleterious	0.14	neutral	-2	neutral	0.66	deleterious	-3.58	low_impact	-0.05	medium_impact	-0.91	medium_impact	0.44	0.9	4.87	7.81	0.53	P	0.76	disease_causing	0.94	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6420	6420	C	T	MI.2983	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	517	173	P	S	Ccc/Tcc	1.75	1	0	probably_damaging	1	neutral	0.75	neutral	2.86	neutral	0.39	neutral	-0.22	neutral_impact	-0.12	0.66	neutral	0.29	neutral	1.52	13.40	neutral	0.36	0.55	0.23	neutral	0.17	neutral	0.1	neutral	0.29	neutral	4	1	deleterious	0.38	neutral	-2	neutral	0.66	deleterious	-3.58	low_impact	0.46	medium_impact	-1.21	low_impact	0.20	0.9	4.87	7.81	0.4	N	0.85	disease_causing	0.96	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6420	6420	C	A	MI.2984	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	517	173	P	T	Ccc/Acc	1.75	1	0	probably_damaging	1	neutral	0.17	neutral	2.84	neutral	0.94	neutral	-0.58	low_impact	0.87	0.67	neutral	0.14	damaging	2.39	18.74	deleterious	0.26	0.55	0.16	neutral	0.26	neutral	0.11	neutral	0.43	neutral	1	1	deleterious	0.09	neutral	-2	neutral	0.66	deleterious	-3.58	low_impact	-0.19	medium_impact	-0.3	medium_impact	0.39	0.9	4.87	7.81	0.49	N	0.80	disease_causing	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6421	6421	C	A	MI.2985	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	518	173	P	H	cCc/cAc	3.6	1	0	probably_damaging	1	deleterious	0.03	neutral	2.78	neutral	-1.08	neutral	-1.88	medium_impact	2.08	0.69	neutral	0.1	damaging	4.04	23.70	deleterious	0.29	0.55	0.46	neutral	0.41	neutral	0.4	neutral	0.46	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-0.65	medium_impact	0.82	medium_impact	0.34	0.9	4.87	7.81	0.43	N	0.81	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6421	6421	C	G	MI.2986	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	518	173	P	R	cCc/cGc	3.6	1	0	probably_damaging	1	deleterious	0.02	neutral	2.88	neutral	0.53	neutral	-2	medium_impact	2.65	0.65	neutral	0.09	damaging	3.56	23.10	deleterious	0.26	0.55	0.22	neutral	0.63	disease	0.46	neutral	0.49	neutral	0	1	deleterious	0.01	neutral	5	deleterious	0.71	deleterious	-3.58	low_impact	-0.75	medium_impact	1.35	medium_impact	0.38	0.9	4.87	7.81	0.37	N	0.90	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6421	6421	C	T	MI.2987	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	518	173	P	L	cCc/cTc	3.6	1	0	probably_damaging	1	neutral	0.07	neutral	2.81	neutral	-0.55	neutral	-1.82	low_impact	1.53	0.65	neutral	0.13	damaging	4.24	23.90	deleterious	0.31	0.55	0.39	neutral	0.42	neutral	0.26	neutral	0.48	neutral	0	1	deleterious	0.04	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.43	medium_impact	0.31	medium_impact	0.69	0.9	4.87	7.81	0.48	P	0.87	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6423	6423	C	A	MI.2988	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	520	174	P	T	Cct/Act	-7.97	0	0	probably_damaging	1	neutral	0.22	neutral	2.75	neutral	-1.67	neutral	-0.56	low_impact	1.24	0.55	damaging	0.1	damaging	2.32	18.31	deleterious	0.44	0.55	0.28	neutral	0.28	neutral	0.29	neutral	0.44	neutral	1	1	deleterious	0.11	neutral	-2	neutral	0.66	deleterious	-3.58	low_impact	-0.11	medium_impact	0.05	medium_impact	0.66	0.9	1.56	6.69	0.37	N	0.80	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6423	6423	C	T	MI.2989	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	520	174	P	S	Cct/Tct	-7.97	0	0	probably_damaging	1	neutral	0.33	neutral	2.73	neutral	-1.58	neutral	-0.16	neutral_impact	0.32	0.54	damaging	0.08	damaging	2.48	19.32	deleterious	0.48	0.55	0.43	neutral	0.24	neutral	0.16	neutral	0.45	neutral	1	1	deleterious	0.17	neutral	-2	neutral	0.68	deleterious	-3.58	low_impact	0.02	medium_impact	-0.8	medium_impact	0.31	0.9	1.56	6.69	0.43	N	0.85	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8666	8666	A	T	MI.299	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	140	47	Q	L	cAa/cTa	-0.33	0	0	benign	0.11	neutral	0.6	neutral	4.34	neutral	-0.85	deleterious	-3.19	neutral_impact	-0.82	0.85	neutral	0.77	neutral	0.08	3.35	deleterious	0.37	0.65	0.35	neutral	0.24	neutral	0.24	neutral	0.44	neutral	1	0.3	neutral	0.75	deleterious	-6	neutral	0.29	neutral	0.11	medium_impact	0.39	medium_impact	-1.8	low_impact	0.30	0.9	22.12	21.76	0.29	N	0.81	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6423	6423	C	G	MI.2990	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	520	174	P	A	Cct/Gct	-7.97	0	0	probably_damaging	0.99	neutral	0.13	neutral	2.71	neutral	-1.51	neutral	-0.9	low_impact	1.89	0.57	damaging	0.24	damaging	1.76	14.76	neutral	0.39	0.55	0.43	neutral	0.18	neutral	0.31	neutral	0.31	neutral	4	1	deleterious	0.07	neutral	-2	neutral	0.67	deleterious	-2.64	low_impact	-0.27	medium_impact	0.65	medium_impact	0.66	0.9	1.56	6.69	0.42	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6424	6424	C	G	MI.2991	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	521	174	P	R	cCt/cGt	3.6	0.99	0	probably_damaging	1	neutral	0.05	neutral	2.71	neutral	-1.53	neutral	-0.73	medium_impact	2.76	0.54	damaging	0.06	damaging	2.45	19.15	deleterious	0.4	0.55	0.51	disease	0.6	disease	0.47	neutral	0.51	disease	0	1	deleterious	0.03	neutral	1	deleterious	0.75	deleterious	-3.58	low_impact	-0.52	medium_impact	1.45	medium_impact	0.57	0.9	1.56	6.69	0.43	N	0.90	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6424	6424	C	A	MI.2992	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	521	174	P	H	cCt/cAt	3.6	0.99	0	probably_damaging	1	deleterious	0.03	neutral	2.68	deleterious	-3.1	neutral	-0.97	medium_impact	2.27	0.56	damaging	0.07	damaging	2.79	21.30	deleterious	0.44	0.55	0.67	disease	0.41	neutral	0.27	neutral	0.63	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-0.65	medium_impact	1	medium_impact	0.51	0.9	1.56	6.69	0.44	N	0.81	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6424	6424	C	T	MI.2993	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	521	174	P	L	cCt/cTt	3.6	0.99	0	probably_damaging	1	neutral	0.05	neutral	2.67	neutral	-2.25	neutral	-1.78	low_impact	1.46	0.57	damaging	0.08	damaging	3.05	22.40	deleterious	0.34	0.55	0.63	disease	0.42	neutral	0.32	neutral	0.61	disease	2	1	deleterious	0.03	neutral	-2	neutral	0.73	deleterious	-3.58	low_impact	-0.52	medium_impact	0.25	medium_impact	0.73	0.9	1.56	6.69	0.45	N	0.87	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6426	6426	G	T	MI.2994	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	523	175	A	S	Gcc/Tcc	-20	0	0	probably_damaging	1	neutral	0.64	neutral	3.01	neutral	-0.36	neutral	0.46	neutral_impact	-1.62	0.63	neutral	0.26	damaging	0.79	9.39	deleterious	0.54	0.6	0.34	neutral	0.27	neutral	0.17	neutral	0.45	neutral	1	1	deleterious	0.32	neutral	-2	neutral	0.69	deleterious	-3.58	low_impact	0.33	medium_impact	-2.6	low_impact	0.81	0.9	2.14	7.35	0.39	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6426	6426	G	A	MI.2995	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	523	175	A	T	Gcc/Acc	-20	0	0	probably_damaging	1	neutral	0.16	neutral	2.98	neutral	-0.82	neutral	-0.89	neutral_impact	-0.46	0.66	neutral	0.24	damaging	1.19	11.72	neutral	0.63	0.65	0.41	neutral	0.36	neutral	0.29	neutral	0.48	neutral	0	1	deleterious	0.08	neutral	-2	neutral	0.71	deleterious	-3.58	low_impact	-0.21	medium_impact	-1.52	low_impact	0.71	0.9	2.14	7.35	0.37	N	0.20	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6426	6426	G	C	MI.2996	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	523	175	A	P	Gcc/Ccc	-20	0	0	probably_damaging	1	deleterious	0.02	neutral	2.95	neutral	-2.27	neutral	-1.55	neutral_impact	0.76	0.6	damaging	0.12	damaging	3.74	23.30	deleterious	0.34	0.55	0.68	disease	0.75	disease	0.28	neutral	0.53	disease	1	1	deleterious	0.01	neutral	2	deleterious	0.84	deleterious	-3.58	low_impact	-0.75	medium_impact	-0.4	medium_impact	0.68	0.9	2.14	7.35	0.28	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6427	6427	C	A	MI.2997	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	524	175	A	D	gCc/gAc	2.44	0.98	0	probably_damaging	1	neutral	0.07	neutral	2.98	neutral	-0.62	neutral	-0.64	neutral_impact	0.22	0.61	neutral	0.12	damaging	4.31	24.00	deleterious	0.28	0.55	0.64	disease	0.68	disease	0.37	neutral	0.48	neutral	0	1	deleterious	0.04	neutral	-2	neutral	0.80	deleterious	-3.58	low_impact	-0.43	medium_impact	-0.9	medium_impact	0.54	0.9	2.14	7.35	0.43	N	0.89	disease_causing	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6427	6427	C	G	MI.2998	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	524	175	A	G	gCc/gGc	2.44	0.98	0	probably_damaging	0.99	neutral	0.91	neutral	3.27	neutral	1.95	neutral	2.81	neutral_impact	-3.02	0.64	neutral	0.21	damaging	-0.55	0.17	neutral	0.58	0.65	0.37	neutral	0.05	neutral	0.13	neutral	0.23	neutral	5	0.99	deleterious	0.46	neutral	-2	neutral	0.63	deleterious	-2.64	low_impact	0.75	medium_impact	-3.89	low_impact	0.69	0.9	2.14	7.35	0.39	N	0.56	disease_causing	0.91	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6427	6427	C	T	MI.2999	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	524	175	A	V	gCc/gTc	2.44	0.98	0	probably_damaging	1	deleterious	0.02	neutral	2.97	neutral	-1.69	neutral	-2.07	neutral_impact	-0.26	0.59	damaging	0.15	damaging	2.74	21.00	deleterious	0.51	0.6	0.62	disease	0.46	neutral	0.32	neutral	0.6	disease	2	1	deleterious	0.01	neutral	2	deleterious	0.76	deleterious	-3.58	low_impact	-0.75	medium_impact	-1.34	low_impact	0.66	0.9	2.14	7.35	0.48	N	0.75	disease_causing	0.92	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8528	8528	T	A	MI.3	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	2	1	M	K	aTg/aAg	5.68	1	0	possibly_damaging	0.8	deleterious	0	neutral	4.49	neutral	-0.95	deleterious	-4.89	NA	NA	0.61	neutral	0.09	damaging	6.26	28.90	deleterious	0.25	0.65	0.39	neutral	0.57	disease	0.67	disease	0.67	disease	3	1	deleterious	0.1	neutral	3	deleterious	0.73	deleterious	NA	NA	NA	NA	NA	NA	0.42	0.9	50	8.74	0.58	P	0.99	NA	NA	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8539	8539	C	G	MI.30	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	13	5	L	V	Ctg/Gtg	-0.33	0	0	probably_damaging	0.95	deleterious	0.04	neutral	4.23	neutral	-1.25	neutral	-2.26	medium_impact	2.93	0.8	neutral	0.5	neutral	3.38	22.90	deleterious	0.44	0.65	0.5	disease	0.33	neutral	0.69	disease	0.44	neutral	1	0.99	deleterious	0.05	neutral	5	deleterious	0.70	deleterious	-1.97	low_impact	-0.49	medium_impact	1.41	medium_impact	0.62	0.9	50.44	8.42	0.39	N	0.81	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8666	8666	A	G	MI.300	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	140	47	Q	R	cAa/cGa	-0.33	0	0	benign	0.01	neutral	0.5	neutral	4.35	neutral	-0.77	neutral	-1.69	low_impact	1.7	0.98	neutral	0.82	neutral	-0.52	0.20	neutral	0.66	0.7	0.35	neutral	0.34	neutral	0.4	neutral	0.44	neutral	1	0.49	neutral	0.75	deleterious	-6	neutral	0.18	neutral	1.14	medium_impact	0.29	medium_impact	0.36	medium_impact	0.57	0.9	22.12	21.76	0.36	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6429	6429	A	G	MI.3000	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	526	176	M	V	Ata/Gta	-13.06	0	0	benign	0	neutral	0.22	neutral	2.71	neutral	-1.97	neutral	-1.99	medium_impact	2.62	0.74	neutral	0.86	neutral	0.81	9.55	deleterious	0.52	0.6	0.4	neutral	0.73	disease	0.47	neutral	0.42	neutral	2	0.78	neutral	0.61	deleterious	-3	neutral	0.22	neutral	2.07	high_impact	-0.11	medium_impact	1.32	medium_impact	0.27	0.9	8.58	22.89	0.41	N	0.05	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6429	6429	A	C	MI.3001	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	526	176	M	L	Ata/Cta	-13.06	0	0	benign	0	neutral	0.24	neutral	2.8	neutral	-1.53	neutral	-1.13	low_impact	1.35	0.72	neutral	0.94	neutral	0.19	4.56	deleterious	0.49	0.55	0.26	neutral	0.58	disease	0.4	neutral	0.38	neutral	2	0.76	neutral	0.62	deleterious	-6	neutral	0.17	neutral	2.07	high_impact	-0.09	medium_impact	0.15	medium_impact	0.41	0.9	8.58	22.89	0.46	N	0.40	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6429	6429	A	T	MI.3002	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	526	176	M	L	Ata/Tta	-13.06	0	0	benign	0	neutral	0.24	neutral	2.8	neutral	-1.53	neutral	-1.13	low_impact	1.35	0.72	neutral	0.94	neutral	0.34	6.09	deleterious	0.49	0.55	0.26	neutral	0.58	disease	0.4	neutral	0.38	neutral	2	0.76	neutral	0.62	deleterious	-6	neutral	0.17	neutral	2.07	high_impact	-0.09	medium_impact	0.15	medium_impact	0.41	0.9	8.58	22.89	0.46	N	0.40	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6430	6430	T	C	MI.3003	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	527	176	M	T	aTa/aCa	0.59	0.06	0	benign	0	deleterious	0.04	neutral	2.69	neutral	-2.79	deleterious	-3.89	high_impact	3.75	0.73	neutral	0.52	neutral	1.04	10.89	neutral	0.49	0.55	0.52	disease	0.83	disease	0.7	disease	0.65	disease	3	0.96	neutral	0.52	deleterious	2	deleterious	0.28	neutral	2.07	high_impact	-0.58	medium_impact	2.36	high_impact	0.20	0.9	8.58	22.89	0.43	N	0.69	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6430	6430	T	A	MI.3004	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	527	176	M	K	aTa/aAa	0.59	0.06	0	benign	0.06	deleterious	0.02	neutral	2.6	deleterious	-3.08	deleterious	-4.38	medium_impact	3.29	0.65	neutral	0.12	damaging	2.11	16.94	deleterious	0.26	0.55	0.65	disease	0.88	disease	0.71	disease	0.68	disease	4	0.98	neutral	0.48	deleterious	1	deleterious	0.35	neutral	0.37	medium_impact	-0.75	medium_impact	1.94	medium_impact	0.35	0.9	8.58	22.89	0.31	N	0.82	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6431	6431	A	C	MI.3005	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	528	176	M	I	atA/atC	4.76	0.72	0	benign	0	neutral	0.92	neutral	2.79	neutral	-2.02	neutral	-1.73	low_impact	1.7	0.74	neutral	0.95	neutral	0.14	4.06	deleterious	0.54	0.6	0.37	neutral	0.56	disease	0.43	neutral	0.38	neutral	2	0.07	neutral	0.96	deleterious	-6	neutral	0.20	neutral	2.07	high_impact	0.78	medium_impact	0.47	medium_impact	0.34	0.9	8.58	22.89	0.4	N	0.51	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6431	6431	A	T	MI.3006	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	528	176	M	I	atA/atT	4.76	0.72	0	benign	0	neutral	0.92	neutral	2.79	neutral	-2.02	neutral	-1.73	low_impact	1.7	0.74	neutral	0.95	neutral	0.17	4.40	deleterious	0.54	0.6	0.37	neutral	0.56	disease	0.43	neutral	0.38	neutral	2	0.07	neutral	0.96	deleterious	-6	neutral	0.20	neutral	2.07	high_impact	0.78	medium_impact	0.47	medium_impact	0.34	0.9	8.58	22.89	0.4	N	0.51	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6432	6432	A	C	MI.3007	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	529	177	T	P	Acc/Ccc	-3.57	0	0	benign	0.33	neutral	0.06	neutral	2.65	neutral	-1.75	neutral	-2.38	low_impact	1.92	0.62	neutral	0.58	neutral	0.43	6.84	deleterious	0.25	0.55	0.66	disease	0.8	disease	0.15	neutral	0.61	disease	2	0.93	neutral	0.37	neutral	-6	neutral	0.38	neutral	-0.47	medium_impact	-0.47	medium_impact	0.67	medium_impact	0.59	0.9	8.38	27.34	0.43	N	0.47	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6432	6432	A	T	MI.3008	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	529	177	T	S	Acc/Tcc	-3.57	0	0	benign	0	neutral	1	neutral	2.79	neutral	-0.72	neutral	0.05	neutral_impact	-0.1	0.81	neutral	1	neutral	-1.41	0.00	neutral	0.52	0.6	0.25	neutral	0.14	neutral	0.11	neutral	0.29	neutral	4	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	1.86	high_impact	-1.19	low_impact	0.63	0.9	8.38	27.34	0.4	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6432	6432	A	G	MI.3009	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	529	177	T	A	Acc/Gcc	-3.57	0	0	benign	0.04	deleterious	0.02	neutral	2.7	neutral	-1.6	neutral	-1.26	medium_impact	2.95	0.68	neutral	0.7	neutral	1.44	12.98	neutral	0.54	0.6	0.4	neutral	0.4	neutral	0.24	neutral	0.47	neutral	1	0.98	neutral	0.49	deleterious	1	deleterious	0.14	neutral	0.54	medium_impact	-0.75	medium_impact	1.63	medium_impact	0.35	0.9	8.38	27.34	0.51	P	0.05	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8666	8666	A	C	MI.301	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	140	47	Q	P	cAa/cCa	-0.33	0	0	possibly_damaging	0.47	neutral	0.28	neutral	4.3	neutral	-2.22	deleterious	-3.11	low_impact	1.36	0.68	neutral	0.31	neutral	0.13	3.88	deleterious	0.2	0.65	0.71	disease	0.71	disease	0.56	disease	0.71	disease	4	0.69	neutral	0.41	neutral	-3	neutral	0.62	deleterious	-0.71	medium_impact	0.06	medium_impact	0.07	medium_impact	0.58	0.9	22.12	21.76	0.26	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6433	6433	C	T	MI.3010	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	530	177	T	I	aCc/aTc	0.59	0.29	0	benign	0.33	deleterious	0.02	neutral	2.63	deleterious	-3.6	deleterious	-2.59	medium_impact	2.5	0.67	neutral	0.6	neutral	1.91	15.62	deleterious	0.48	0.55	0.65	disease	0.66	disease	0.19	neutral	0.49	neutral	0	0.98	neutral	0.35	neutral	1	deleterious	0.33	neutral	-0.47	medium_impact	-0.75	medium_impact	1.21	medium_impact	0.46	0.9	8.38	27.34	0.35	N	0.71	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6433	6433	C	G	MI.3011	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	530	177	T	S	aCc/aGc	0.59	0.29	0	benign	0	neutral	1	neutral	2.79	neutral	-0.72	neutral	0.05	neutral_impact	-0.1	0.81	neutral	1	neutral	-1.21	0.01	neutral	0.52	0.6	0.25	neutral	0.14	neutral	0.11	neutral	0.29	neutral	4	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	1.86	high_impact	-1.19	low_impact	0.63	0.9	8.38	27.34	0.32	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6433	6433	C	A	MI.3012	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	530	177	T	N	aCc/aAc	0.59	0.29	0	benign	0.13	neutral	0.24	neutral	2.7	neutral	-1.92	neutral	-1.05	low_impact	1.2	0.7	neutral	0.75	neutral	0.51	7.54	deleterious	0.64	0.7	0.46	neutral	0.54	disease	0.27	neutral	0.46	neutral	1	0.72	neutral	0.56	deleterious	-6	neutral	0.20	neutral	0.02	medium_impact	-0.09	medium_impact	0.01	medium_impact	0.70	0.9	8.38	27.34	0.43	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6435	6435	C	A	MI.3013	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	532	178	Q	K	Caa/Aaa	-6.35	0	0	probably_damaging	0.98	neutral	0.29	neutral	2.82	neutral	0.34	neutral	-0.51	neutral_impact	-0.2	0.6	damaging	0.12	damaging	2.74	21.00	deleterious	0.44	0.55	0.49	neutral	0.51	disease	0.53	disease	0.51	disease	0	0.98	deleterious	0.16	neutral	-2	neutral	0.72	deleterious	-2.35	low_impact	-0.02	medium_impact	-1.28	low_impact	0.40	0.9	1.56	7.91	0.29	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6435	6435	C	G	MI.3014	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	532	178	Q	E	Caa/Gaa	-6.35	0	0	probably_damaging	0.95	neutral	0.27	neutral	2.81	neutral	0.17	neutral	-0.91	neutral_impact	0.14	0.6	neutral	0.14	damaging	1.90	15.57	deleterious	0.47	0.55	0.52	disease	0.48	neutral	0.53	disease	0.55	disease	1	0.96	neutral	0.16	neutral	-2	neutral	0.72	deleterious	-1.96	low_impact	-0.05	medium_impact	-0.97	medium_impact	0.52	0.9	1.56	7.91	0.29	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6436	6436	A	C	MI.3015	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	533	178	Q	P	cAa/cCa	5.45	1	0	probably_damaging	0.99	neutral	0.21	neutral	2.79	neutral	-0.77	neutral	-1.32	neutral_impact	-1.4	0.61	neutral	0.2	damaging	1.83	15.14	deleterious	0.26	0.55	0.62	disease	0.72	disease	0.36	neutral	0.53	disease	1	1	deleterious	0.11	neutral	-2	neutral	0.82	deleterious	-2.64	low_impact	-0.13	medium_impact	-2.39	low_impact	0.40	0.9	1.56	7.91	0.43	N	0.84	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6436	6436	A	G	MI.3016	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	533	178	Q	R	cAa/cGa	5.45	1	0	probably_damaging	0.98	neutral	0.34	neutral	2.79	neutral	-0.78	neutral	-0.55	neutral_impact	0.34	0.6	neutral	0.13	damaging	2.21	17.58	deleterious	0.52	0.6	0.52	disease	0.61	disease	0.56	disease	0.69	disease	4	0.99	deleterious	0.18	neutral	-2	neutral	0.76	deleterious	-2.35	low_impact	0.03	medium_impact	-0.79	medium_impact	0.29	0.9	1.56	7.91	0.45	N	0.76	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6436	6436	A	T	MI.3017	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	533	178	Q	L	cAa/cTa	5.45	1	0	probably_damaging	0.98	neutral	0.68	neutral	3.12	neutral	3.3	neutral	2.07	neutral_impact	-3.52	0.67	neutral	0.21	damaging	1.07	11.04	neutral	0.33	0.55	0.23	neutral	0.25	neutral	0.15	neutral	0.42	neutral	2	0.97	neutral	0.35	neutral	-2	neutral	0.65	deleterious	-2.35	low_impact	0.38	medium_impact	-4.35	low_impact	0.21	0.9	1.56	7.91	0.45	N	0.71	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6437	6437	A	C	MI.3018	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	534	178	Q	H	caA/caC	8.69	1	0	probably_damaging	1	neutral	0.55	neutral	2.78	neutral	-1.35	neutral	-0.52	neutral_impact	0.34	0.59	damaging	0.12	damaging	2.10	16.88	deleterious	0.52	0.6	0.37	neutral	0.39	neutral	0.51	disease	0.48	neutral	0	1	deleterious	0.28	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	0.24	medium_impact	-0.79	medium_impact	0.46	0.9	1.56	7.91	0.46	N	0.70	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6437	6437	A	T	MI.3019	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	534	178	Q	H	caA/caT	8.69	1	0	probably_damaging	1	neutral	0.55	neutral	2.78	neutral	-1.35	neutral	-0.52	neutral_impact	0.34	0.59	damaging	0.12	damaging	2.24	17.77	deleterious	0.52	0.6	0.37	neutral	0.39	neutral	0.51	disease	0.48	neutral	0	1	deleterious	0.28	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	0.24	medium_impact	-0.79	medium_impact	0.46	0.9	1.56	7.91	0.46	N	0.70	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8667	8667	A	C	MI.302	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	141	47	Q	H	caA/caC	-0.33	0	0	possibly_damaging	0.66	neutral	0.35	neutral	4.31	neutral	-1.92	deleterious	-2.54	low_impact	0.9	0.89	neutral	0.77	neutral	1.92	15.69	deleterious	0.68	0.75	0.59	disease	0.23	neutral	0.4	neutral	0.54	disease	1	0.72	neutral	0.35	neutral	-3	neutral	0.59	deleterious	-1.03	low_impact	0.14	medium_impact	-0.33	medium_impact	0.81	0.9	22.12	21.76	0.44	N	0.18	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6438	6438	T	C	MI.3020	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	535	179	Y	H	Tac/Cac	-0.33	0.1	0	probably_damaging	1	neutral	0.23	neutral	2.81	neutral	1.61	neutral	1.15	neutral_impact	-1.03	0.61	neutral	0.11	damaging	2.35	18.49	deleterious	0.61	0.65	0.33	neutral	0.28	neutral	0.18	neutral	0.45	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.69	deleterious	-3.58	low_impact	-0.1	medium_impact	-2.05	low_impact	0.38	0.9	1.17	6.78	0.47	N	0.61	disease_causing	0.81	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6438	6438	T	G	MI.3021	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	535	179	Y	D	Tac/Gac	-0.33	0.1	0	probably_damaging	1	neutral	1	neutral	2.86	neutral	1.68	neutral	4.11	neutral_impact	-2.85	0.67	neutral	0.27	damaging	1.20	11.72	neutral	0.46	0.55	0.44	neutral	0.21	neutral	0.32	neutral	0.36	neutral	3	1	deleterious	0.5	deleterious	-2	neutral	0.69	deleterious	-3.58	low_impact	1.86	high_impact	-3.73	low_impact	0.44	0.9	1.17	6.78	0.25	N	0.98	disease_causing	0.97	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6438	6438	T	A	MI.3022	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	535	179	Y	N	Tac/Aac	-0.33	0.1	0	probably_damaging	1	neutral	0.93	neutral	2.87	neutral	1.73	neutral	1.74	neutral_impact	-1.11	0.64	neutral	0.12	damaging	3.02	22.30	deleterious	0.42	0.55	0.31	neutral	0.58	disease	0.28	neutral	0.44	neutral	1	1	deleterious	0.47	neutral	-2	neutral	0.72	deleterious	-3.58	low_impact	0.82	medium_impact	-2.12	low_impact	0.36	0.9	1.17	6.78	0.25	N	0.94	disease_causing	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6439	6439	A	T	MI.3023	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	536	179	Y	F	tAc/tTc	5.68	1	0	probably_damaging	0.98	neutral	0.1	neutral	2.83	neutral	1.65	neutral	-0.69	neutral_impact	-0.84	0.63	neutral	0.24	damaging	2.03	16.39	deleterious	0.35	0.55	0.24	neutral	0.45	neutral	0.23	neutral	0.48	neutral	1	0.99	deleterious	0.06	neutral	-2	neutral	0.70	deleterious	-2.35	low_impact	-0.34	medium_impact	-1.88	low_impact	0.30	0.9	1.17	6.78	0.57	P	0.50	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6439	6439	A	C	MI.3024	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	536	179	Y	S	tAc/tCc	5.68	1	0	probably_damaging	1	neutral	0.47	neutral	2.97	neutral	2.05	neutral	1.23	neutral_impact	-0.98	0.66	neutral	0.15	damaging	2.46	19.21	deleterious	0.34	0.55	0.34	neutral	0.52	disease	0.31	neutral	0.46	neutral	1	1	deleterious	0.24	neutral	-2	neutral	0.71	deleterious	-3.58	low_impact	0.16	medium_impact	-2	low_impact	0.39	0.9	1.17	6.78	0.44	N	0.90	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6439	6439	A	G	MI.3025	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	536	179	Y	C	tAc/tGc	5.68	1	0	probably_damaging	1	neutral	0.05	neutral	2.78	neutral	-1.55	neutral	-1.48	low_impact	1.32	0.62	neutral	0.1	damaging	3.35	22.90	deleterious	0.37	0.55	0.7	disease	0.71	disease	0.44	neutral	0.49	neutral	0	1	deleterious	0.03	neutral	-2	neutral	0.79	deleterious	-3.58	low_impact	-0.52	medium_impact	0.12	medium_impact	0.14	0.9	1.17	6.78	0.45	N	0.89	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6441	6441	C	G	MI.3026	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	538	180	Q	E	Caa/Gaa	-2.88	0	0	benign	0.24	deleterious	0.01	neutral	2.97	neutral	0.29	neutral	-1.32	medium_impact	2.97	0.62	neutral	0.13	damaging	3.01	22.30	deleterious	0.54	0.6	0.26	neutral	0.66	disease	0.54	disease	0.64	disease	3	0.99	deleterious	0.39	neutral	1	deleterious	0.30	neutral	-0.29	medium_impact	-0.92	medium_impact	1.64	medium_impact	0.59	0.9	4.68	15.51	0.33	N	0.72	disease_causing	0.84	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6441	6441	C	A	MI.3027	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	538	180	Q	K	Caa/Aaa	-2.88	0	0	benign	0.34	neutral	0.08	neutral	3.11	neutral	1.62	neutral	-0.41	neutral_impact	0.08	0.63	neutral	0.14	damaging	2.80	21.40	deleterious	0.58	0.65	0.21	neutral	0.41	neutral	0.17	neutral	0.45	neutral	1	0.91	neutral	0.37	neutral	-6	neutral	0.39	neutral	-0.49	medium_impact	-0.4	medium_impact	-1.03	low_impact	0.61	0.9	4.68	15.51	0.49	N	0.83	disease_causing	0.91	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6442	6442	A	G	MI.3028	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	539	180	Q	R	cAa/cGa	4.52	1	0	possibly_damaging	0.45	neutral	0.52	neutral	3.15	neutral	1.79	neutral	0.41	neutral_impact	-0.74	0.62	neutral	0.24	damaging	0.73	9.04	deleterious	0.63	0.65	0.22	neutral	0.25	neutral	0.19	neutral	0.43	neutral	1	0.45	neutral	0.54	deleterious	-3	neutral	0.38	neutral	-0.67	medium_impact	0.21	medium_impact	-1.78	low_impact	0.40	0.9	4.68	15.51	0.49	P	0.76	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6442	6442	A	T	MI.3029	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	539	180	Q	L	cAa/cTa	4.52	1	0	possibly_damaging	0.55	neutral	0.06	neutral	3.07	neutral	-1.15	deleterious	-3.75	low_impact	1.6	0.61	neutral	0.13	damaging	3.75	23.30	deleterious	0.36	0.55	0.34	neutral	0.73	disease	0.4	neutral	0.51	disease	0	0.94	neutral	0.26	neutral	-3	neutral	0.51	deleterious	-0.84	medium_impact	-0.47	medium_impact	0.38	medium_impact	0.25	0.9	4.68	15.51	0.47	N	0.71	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8667	8667	A	T	MI.303	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	141	47	Q	H	caA/caT	-0.33	0	0	possibly_damaging	0.66	neutral	0.35	neutral	4.31	neutral	-1.92	deleterious	-2.54	low_impact	0.9	0.89	neutral	0.77	neutral	2.01	16.26	deleterious	0.68	0.75	0.59	disease	0.23	neutral	0.4	neutral	0.54	disease	1	0.72	neutral	0.35	neutral	-3	neutral	0.59	deleterious	-1.03	low_impact	0.14	medium_impact	-0.33	medium_impact	0.81	0.9	22.12	21.76	0.44	N	0.18	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6442	6442	A	C	MI.3030	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	539	180	Q	P	cAa/cCa	4.52	1	0	possibly_damaging	0.9	deleterious	0.01	neutral	2.97	neutral	-1.51	deleterious	-3.33	medium_impact	3.31	0.57	damaging	0.12	damaging	3.30	22.90	deleterious	0.2	0.55	0.2	neutral	0.88	disease	0.54	disease	0.76	disease	5	1	deleterious	0.06	neutral	4	deleterious	0.69	deleterious	-1.65	low_impact	-0.92	medium_impact	1.96	medium_impact	0.46	0.9	4.68	15.51	0.4	N	0.84	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6443	6443	A	T	MI.3031	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	540	180	Q	H	caA/caT	8.69	1	0	benign	0.02	neutral	0.2	neutral	2.95	neutral	-1.39	neutral	-2.15	medium_impact	2.38	0.59	damaging	0.21	damaging	3.47	23.00	deleterious	0.59	0.65	0.37	neutral	0.58	disease	0.28	neutral	0.47	neutral	1	0.79	neutral	0.59	deleterious	-3	neutral	0.19	neutral	0.83	medium_impact	-0.14	medium_impact	1.1	medium_impact	0.59	0.9	4.68	15.51	0.6	P	0.70	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6443	6443	A	C	MI.3032	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	540	180	Q	H	caA/caC	8.69	1	0	benign	0.02	neutral	0.2	neutral	2.95	neutral	-1.39	neutral	-2.15	medium_impact	2.38	0.59	damaging	0.21	damaging	3.25	22.80	deleterious	0.59	0.65	0.37	neutral	0.58	disease	0.28	neutral	0.47	neutral	1	0.79	neutral	0.59	deleterious	-3	neutral	0.19	neutral	0.83	medium_impact	-0.14	medium_impact	1.1	medium_impact	0.59	0.9	4.68	15.51	0.6	P	0.70	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6444	6444	A	C	MI.3033	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	541	181	T	P	Acg/Ccg	0.82	0.99	0	probably_damaging	0.92	neutral	0.05	neutral	2.74	neutral	-2.32	neutral	-1.81	medium_impact	2.98	0.61	neutral	0.44	neutral	3.29	22.80	deleterious	0.17	0.55	0.61	disease	0.76	disease	0.45	neutral	0.58	disease	2	0.98	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-1.76	low_impact	-0.52	medium_impact	1.65	medium_impact	0.51	0.9	6.63	13.64	0.45	N	0.92	disease_causing	0.93	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6444	6444	A	G	MI.3034	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	541	181	T	A	Acg/Gcg	0.82	0.99	0	benign	0.28	neutral	0.21	neutral	2.8	neutral	-0.06	neutral	-0.46	low_impact	1.82	0.66	neutral	0.55	neutral	1.48	13.19	neutral	0.53	0.6	0.3	neutral	0.31	neutral	0.49	neutral	0.46	neutral	1	0.75	neutral	0.47	neutral	-6	neutral	0.21	neutral	-0.37	medium_impact	-0.13	medium_impact	0.58	medium_impact	0.34	0.9	6.63	13.64	0.52	P	0.69	disease_causing	0.74	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6444	6444	A	T	MI.3035	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	541	181	T	S	Acg/Tcg	0.82	0.99	0	benign	0.42	deleterious	0.04	neutral	2.78	neutral	-0.56	neutral	-1	low_impact	1.48	0.66	neutral	0.54	neutral	1.32	12.38	neutral	0.49	0.55	0.34	neutral	0.34	neutral	0.35	neutral	0.46	neutral	1	0.95	neutral	0.31	neutral	-2	neutral	0.28	neutral	-0.62	medium_impact	-0.58	medium_impact	0.27	medium_impact	0.73	0.9	6.63	13.64	0.49	P	0.79	polymorphism	0.52	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6445	6445	C	A	MI.3036	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	542	181	T	K	aCg/aAg	6.84	1	0	probably_damaging	0.92	deleterious	0.04	neutral	2.75	neutral	-1.67	neutral	-1.35	medium_impact	2.98	0.63	neutral	0.44	neutral	4.39	24.10	deleterious	0.25	0.55	0.43	neutral	0.6	disease	0.6	disease	0.71	disease	4	0.99	deleterious	0.06	neutral	5	deleterious	0.57	deleterious	-1.76	low_impact	-0.58	medium_impact	1.65	medium_impact	0.65	0.9	6.63	13.64	0.54	P	0.88	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6445	6445	C	T	MI.3037	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	542	181	T	M	aCg/aTg	6.84	1	0	possibly_damaging	0.8	neutral	0.74	neutral	3.02	neutral	1.93	neutral	2.13	neutral_impact	-1.29	0.67	neutral	0.76	neutral	0.84	9.70	deleterious	0.38	0.55	0.21	neutral	0.07	neutral	0.15	neutral	0.24	neutral	5	0.76	neutral	0.47	deleterious	-3	neutral	0.22	neutral	-1.32	low_impact	0.45	medium_impact	-2.29	low_impact	0.68	0.9	6.63	13.64	0.54	P	0.96	disease_causing	1	0.01	rs879164161	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6447	6447	C	G	MI.3038	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	544	182	P	A	Ccc/Gcc	-8.89	0	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-3	deleterious	-6.14	high_impact	4.12	0.62	neutral	0.44	neutral	3.05	22.40	deleterious	0.29	0.55	0.54	disease	0.57	disease	0.72	disease	0.64	disease	3	1	deleterious	0	deleterious	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.86	0.9	2.53	6.7	0.4	N	0.76	polymorphism	0.93	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6447	6447	C	T	MI.3039	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	544	182	P	S	Ccc/Tcc	-8.89	0	0	probably_damaging	1	neutral	0.32	neutral	2.64	deleterious	-3.06	deleterious	-5.91	low_impact	1.41	0.6	damaging	0.38	neutral	3.80	23.40	deleterious	0.41	0.55	0.5	neutral	0.59	disease	0.52	disease	0.43	neutral	1	1	deleterious	0.16	neutral	-2	neutral	0.76	deleterious	-3.58	low_impact	0.01	medium_impact	0.2	medium_impact	0.42	0.9	2.53	6.7	0.26	N	0.85	polymorphism	0.89	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8668	8668	T	G	MI.304	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	142	48	W	G	Tga/Gga	-1.26	0	0	probably_damaging	0.99	neutral	0.37	neutral	4.28	neutral	-2.26	deleterious	-10.89	medium_impact	2.25	0.84	neutral	0.45	neutral	3.76	23.30	deleterious	0.3	0.65	0.45	neutral	0.81	disease	0.73	disease	0.75	disease	5	0.99	deleterious	0.19	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	0.16	medium_impact	0.83	medium_impact	0.36	0.9	19.47	20.58	0.36	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6447	6447	C	A	MI.3040	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	544	182	P	T	Ccc/Acc	-8.89	0	0	probably_damaging	1	deleterious	0.01	neutral	2.6	deleterious	-3.72	deleterious	-6.1	medium_impact	2.64	0.57	damaging	0.31	neutral	3.63	23.20	deleterious	0.33	0.55	0.59	disease	0.7	disease	0.55	disease	0.52	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-0.92	medium_impact	1.34	medium_impact	0.89	0.9	2.53	6.7	0.25	N	0.80	polymorphism	0.89	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6448	6448	C	G	MI.3041	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	545	182	P	R	cCc/cGc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.86	deleterious	-7.06	high_impact	5.01	0.56	damaging	0.3	neutral	3.50	23.10	deleterious	0.22	0.55	0.77	disease	0.86	disease	0.82	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.53	high_impact	0.84	0.9	2.53	6.7	0.68	P	0.90	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6448	6448	C	T	MI.3042	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	545	182	P	L	cCc/cTc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-4.2	deleterious	-7.91	high_impact	4.21	0.54	damaging	0.37	neutral	4.35	24.10	deleterious	0.33	0.55	0.67	disease	0.8	disease	0.7	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.79	high_impact	0.87	0.9	2.53	6.7	0.51	P	0.87	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6448	6448	C	A	MI.3043	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	545	182	P	H	cCc/cAc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.91	deleterious	-7.06	high_impact	4.66	0.57	damaging	0.29	neutral	3.91	23.50	deleterious	0.28	0.55	0.85	disease	0.81	disease	0.8	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.77	0.9	2.53	6.7	0.58	P	0.81	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6450	6450	C	G	MI.3044	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	547	183	L	V	Ctc/Gtc	-13.98	0	0	probably_damaging	0.99	neutral	0.06	neutral	2.25	neutral	-2.2	deleterious	-2.61	high_impact	3.58	0.51	damaging	0.06	damaging	3.38	22.90	deleterious	0.37	0.55	0.47	neutral	0.64	disease	0.66	disease	0.66	disease	3	1	deleterious	0.04	neutral	2	deleterious	0.77	deleterious	-2.64	low_impact	-0.47	medium_impact	2.21	high_impact	0.70	0.9	1.95	6.68	0.27	N	0.66	polymorphism	0.97	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6450	6450	C	T	MI.3045	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	547	183	L	F	Ctc/Ttc	-13.98	0	0	probably_damaging	1	deleterious	0	neutral	2.11	deleterious	-3.94	deleterious	-3.48	high_impact	4.86	0.5	damaging	0.04	damaging	3.90	23.50	deleterious	0.35	0.55	0.57	disease	0.76	disease	0.66	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.74	0.9	1.95	6.68	0.58	P	0.87	polymorphism	0.88	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6450	6450	C	A	MI.3046	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	547	183	L	I	Ctc/Atc	-13.98	0	0	probably_damaging	1	deleterious	0	neutral	2.42	neutral	-1.23	neutral	-1.74	medium_impact	3.02	0.52	damaging	0.06	damaging	4.02	23.60	deleterious	0.31	0.55	0.29	neutral	0.67	disease	0.55	disease	0.62	disease	2	1	deleterious	0	neutral	5	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	1.69	medium_impact	0.81	0.9	1.95	6.68	0.28	N	0.54	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6451	6451	T	G	MI.3047	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	548	183	L	R	cTc/cGc	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.06	deleterious	-6.86	deleterious	-5.22	high_impact	5.21	0.5	damaging	0.04	damaging	4.14	23.80	deleterious	0.14	0.55	0.93	disease	0.89	disease	0.77	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.71	high_impact	0.58	0.9	1.95	6.68	0.59	P	0.90	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6451	6451	T	A	MI.3048	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	548	183	L	H	cTc/cAc	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.05	deleterious	-7.56	deleterious	-6.09	high_impact	5.21	0.54	damaging	0.05	damaging	4.03	23.60	deleterious	0.17	0.55	0.95	disease	0.81	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.71	high_impact	0.68	0.9	1.95	6.68	0.52	P	0.83	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6451	6451	T	C	MI.3049	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	548	183	L	P	cTc/cCc	-0.33	0	0	probably_damaging	1	neutral	0.05	neutral	2.05	deleterious	-7.25	deleterious	-6.09	high_impact	4.05	0.39	damaging	0.05	damaging	3.81	23.40	deleterious	0.14	0.55	0.94	disease	0.8	disease	0.74	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.89	deleterious	-3.58	low_impact	-0.52	medium_impact	2.64	high_impact	0.59	0.9	1.95	6.68	0.44	N	0.83	disease_causing	0.71	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8668	8668	T	C	MI.305	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	142	48	W	R	Tga/Cga	-1.26	0	0	probably_damaging	1	neutral	0.34	neutral	4.28	neutral	-2.46	deleterious	-11.72	medium_impact	3.06	0.92	neutral	0.36	neutral	3.47	23.00	deleterious	0.32	0.65	0.56	disease	0.88	disease	0.73	disease	0.8	disease	6	1	deleterious	0.17	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	0.13	medium_impact	1.53	medium_impact	0.32	0.9	19.47	20.58	0.49	N	0.96	polymorphism	1	0.18	.	.	.	.	.	.	COSM6716152	.	.	T8668C	LHON	+	-	Reported	1	.	P	P	damaging
chrM	6453	6453	T	C	MI.3050	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	550	184	F	L	Ttc/Ctc	-3.34	0	0	probably_damaging	0.99	deleterious	0.03	neutral	2.57	neutral	-1.32	deleterious	-4.93	medium_impact	2.73	0.56	damaging	0.19	damaging	3.95	23.60	deleterious	0.34	0.55	0.42	neutral	0.73	disease	0.61	disease	0.37	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-2.64	low_impact	-0.65	medium_impact	1.42	medium_impact	0.77	0.9	4.48	7.68	0.28	N	0.83	polymorphism	0.91	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6453	6453	T	G	MI.3051	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	550	184	F	V	Ttc/Gtc	-3.34	0	0	probably_damaging	1	deleterious	0.03	neutral	2.59	neutral	-1.16	deleterious	-5.82	high_impact	4.4	0.63	neutral	0.16	damaging	3.99	23.60	deleterious	0.25	0.55	0.37	neutral	0.85	disease	0.69	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-0.65	medium_impact	2.96	high_impact	0.64	0.9	4.48	7.68	0.39	N	0.84	polymorphism	0.84	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6453	6453	T	A	MI.3052	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	550	184	F	I	Ttc/Atc	-3.34	0	0	probably_damaging	1	deleterious	0.03	neutral	2.48	neutral	-2.23	deleterious	-4.98	medium_impact	3.36	0.71	neutral	0.18	damaging	4.34	24.00	deleterious	0.21	0.55	0.48	neutral	0.81	disease	0.65	disease	0.67	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-0.65	medium_impact	2	high_impact	0.70	0.9	4.48	7.68	0.31	N	0.88	polymorphism	0.92	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6454	6454	T	A	MI.3053	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	551	184	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.45	neutral	-2.88	neutral	-2.43	medium_impact	3.34	0.68	neutral	0.16	damaging	4.24	23.90	deleterious	0.21	0.55	0.54	disease	0.75	disease	0.64	disease	0.55	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	1.99	medium_impact	0.70	0.9	4.48	7.68	0.53	P	0.59	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6454	6454	T	C	MI.3054	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	551	184	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.08	deleterious	-6.73	high_impact	4.05	0.75	neutral	0.2	damaging	4.22	23.90	deleterious	0.22	0.55	0.48	neutral	0.84	disease	0.67	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.64	high_impact	0.57	0.9	4.48	7.68	0.5	N	0.84	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6454	6454	T	G	MI.3055	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	551	184	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.4	deleterious	-4.66	deleterious	-6.71	high_impact	5.21	0.67	neutral	0.16	damaging	4.07	23.70	deleterious	0.21	0.55	0.78	disease	0.85	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.71	high_impact	0.39	0.9	4.48	7.68	0.66	P	0.91	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6455	6455	C	A	MI.3056	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	552	184	F	L	ttC/ttA	7.53	1	0.18	probably_damaging	0.99	deleterious	0.03	neutral	2.57	neutral	-1.32	deleterious	-4.93	medium_impact	2.73	0.56	damaging	0.19	damaging	4.64	24.50	deleterious	0.34	0.55	0.42	neutral	0.73	disease	0.61	disease	0.37	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-2.64	low_impact	-0.65	medium_impact	1.42	medium_impact	0.77	0.9	4.48	7.68	0.51	P	0.83	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6455	6455	C	G	MI.3057	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	552	184	F	L	ttC/ttG	7.53	1	0.18	probably_damaging	0.99	deleterious	0.03	neutral	2.57	neutral	-1.32	deleterious	-4.93	medium_impact	2.73	0.56	damaging	0.19	damaging	4.28	24.00	deleterious	0.34	0.55	0.42	neutral	0.73	disease	0.61	disease	0.37	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-2.64	low_impact	-0.65	medium_impact	1.42	medium_impact	0.77	0.9	4.48	7.68	0.5	P	0.83	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6456	6456	G	T	MI.3058	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	553	185	V	F	Gtc/Ttc	-3.34	0	0	possibly_damaging	0.86	deleterious	0	neutral	2.57	neutral	-2.79	deleterious	-3.87	high_impact	4.75	0.6	neutral	0.48	neutral	3.77	23.40	deleterious	0.15	0.55	0.62	disease	0.91	disease	0.62	disease	0.72	disease	4	1	deleterious	0.07	neutral	5	deleterious	0.77	deleterious	-1.5	low_impact	-1.48	low_impact	3.29	high_impact	0.68	0.9	3.31	6.74	0.66	P	0.86	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6456	6456	G	C	MI.3059	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	553	185	V	L	Gtc/Ctc	-3.34	0	0	benign	0.06	deleterious	0	neutral	2.68	neutral	-1.33	neutral	-2.22	medium_impact	2.81	0.56	damaging	0.55	neutral	3.46	23.00	deleterious	0.36	0.55	0.36	neutral	0.76	disease	0.55	disease	0.58	disease	2	1	deleterious	0.47	deleterious	1	deleterious	0.23	neutral	0.37	medium_impact	-1.48	low_impact	1.5	medium_impact	0.63	0.9	3.31	6.74	0.39	N	0.55	disease_causing	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8669	8669	G	C	MI.306	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	143	48	W	S	tGa/tCa	2.44	0.98	0.01	probably_damaging	1	neutral	0.51	neutral	4.32	neutral	-1.16	deleterious	-11.64	low_impact	1.29	0.88	neutral	0.5	neutral	3.84	23.40	deleterious	0.31	0.65	0.47	neutral	0.83	disease	0.61	disease	0.55	disease	1	1	deleterious	0.26	neutral	-2	neutral	0.80	deleterious	-3.6	low_impact	0.3	medium_impact	0.01	medium_impact	0.36	0.9	19.47	20.58	0.43	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6456	6456	G	A	MI.3060	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	553	185	V	I	Gtc/Atc	-3.34	0	0	benign	0.01	neutral	0.09	neutral	2.65	neutral	-1.01	neutral	-0.71	low_impact	1.78	0.56	damaging	0.59	neutral	2.40	18.82	deleterious	0.47	0.55	0.38	neutral	0.47	neutral	0.38	neutral	0.42	neutral	2	0.91	neutral	0.54	deleterious	-6	neutral	0.19	neutral	1.12	medium_impact	-0.37	medium_impact	0.55	medium_impact	0.84	0.9	3.31	6.74	0.51	N	0.24	disease_causing	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6457	6457	T	G	MI.3061	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	554	185	V	G	gTc/gGc	3.6	1	0	probably_damaging	0.94	deleterious	0	neutral	2.56	neutral	-2.88	deleterious	-5.41	high_impact	3.85	0.63	neutral	0.6	neutral	3.77	23.40	deleterious	0.15	0.55	0.66	disease	0.8	disease	0.6	disease	0.55	disease	1	1	deleterious	0.03	neutral	6	deleterious	0.77	deleterious	-1.88	low_impact	-1.48	low_impact	2.46	high_impact	0.55	0.9	3.31	6.74	0.41	N	0.71	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6457	6457	T	A	MI.3062	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	554	185	V	D	gTc/gAc	3.6	1	0	probably_damaging	0.94	deleterious	0	neutral	2.51	deleterious	-4.38	deleterious	-5.34	high_impact	4.75	0.67	neutral	0.47	neutral	4.41	24.10	deleterious	0.08	0.55	0.82	disease	0.9	disease	0.72	disease	0.76	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.82	deleterious	-1.88	low_impact	-1.48	low_impact	3.29	high_impact	0.68	0.9	3.31	6.74	0.62	P	0.83	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6457	6457	T	C	MI.3063	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	554	185	V	A	gTc/gCc	3.6	1	0	possibly_damaging	0.66	deleterious	0.03	neutral	2.67	neutral	-0.58	deleterious	-2.94	medium_impact	2.52	0.63	neutral	0.6	neutral	3.47	23.00	deleterious	0.33	0.55	0.34	neutral	0.53	disease	0.41	neutral	0.44	neutral	1	0.97	neutral	0.19	neutral	4	deleterious	0.52	deleterious	-1.03	low_impact	-0.65	medium_impact	1.23	medium_impact	0.61	0.9	3.31	6.74	0.48	P	0.47	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6459	6459	T	C	MI.3064	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	556	186	W	R	Tga/Cga	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.28	deleterious	-5.57	deleterious	-12.13	high_impact	4.75	0.62	neutral	0.04	damaging	3.51	23.10	deleterious	0.19	0.55	0.77	disease	0.92	disease	0.82	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.30	0.9	0.97	6.71	0.49	N	0.98	polymorphism	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6459	6459	T	G	MI.3065	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	556	186	W	G	Tga/Gga	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.29	deleterious	-5.28	deleterious	-11.27	high_impact	5.29	0.66	neutral	0.05	damaging	3.83	23.40	deleterious	0.17	0.55	0.8	disease	0.86	disease	0.78	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.28	0.9	0.97	6.71	0.5	N	0.89	polymorphism	0.98	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6460	6460	G	C	MI.3066	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	557	186	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.3	deleterious	-4.73	deleterious	-12.12	high_impact	5.29	0.65	neutral	0.06	damaging	4.05	23.70	deleterious	0.17	0.55	0.68	disease	0.91	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.25	0.9	0.97	6.71	0.55	P	0.89	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6460	6460	G	T	MI.3067	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	557	186	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.4	deleterious	-3.23	deleterious	-11.25	high_impact	4.6	0.69	neutral	0.04	damaging	4.25	23.90	deleterious	0.16	0.55	0.5	neutral	0.86	disease	0.74	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.15	high_impact	0.24	0.9	0.97	6.71	0.54	P	0.95	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6461	6461	A	C	MI.3068	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	558	186	W	C	tgA/tgC	9.15	1	0.01	probably_damaging	1	deleterious	0	neutral	2.28	deleterious	-6.19	deleterious	-11.26	high_impact	5.29	0.59	damaging	0.05	damaging	4.00	23.60	deleterious	0.2	0.55	0.84	disease	0.9	disease	0.8	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.26	0.9	0.97	6.71	0.59	P	0.88	disease_causing	1	0.50	rs879168265	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6461	6461	A	T	MI.3069	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	558	186	W	C	tgA/tgT	9.15	1	0.01	probably_damaging	1	deleterious	0	neutral	2.28	deleterious	-6.19	deleterious	-11.26	high_impact	5.29	0.59	damaging	0.05	damaging	4.09	23.70	deleterious	0.2	0.55	0.84	disease	0.9	disease	0.8	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.26	0.9	0.97	6.71	0.54	P	0.88	disease_causing	1	0.50	rs879168265	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8669	8669	G	T	MI.307	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	143	48	W	L	tGa/tTa	2.44	0.98	0.01	probably_damaging	0.99	neutral	0.82	neutral	4.55	neutral	-0.2	deleterious	-10.97	low_impact	1.25	0.84	neutral	0.54	neutral	4.08	23.70	deleterious	0.28	0.65	0.35	neutral	0.7	disease	0.56	disease	0.52	disease	0	0.99	deleterious	0.42	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	0.66	medium_impact	-0.03	medium_impact	0.25	0.9	19.47	20.58	0.32	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6462	6462	T	C	MI.3070	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	559	187	S	P	Tcc/Ccc	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-3.78	deleterious	-3.72	high_impact	4.9	0.44	damaging	0.06	damaging	3.91	23.50	deleterious	0.17	0.55	0.65	disease	0.89	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.43	high_impact	0.77	0.9	2.14	6.81	0.69	P	0.91	disease_causing	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6462	6462	T	G	MI.3071	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	559	187	S	A	Tcc/Gcc	3.83	1	0	probably_damaging	0.99	neutral	0.39	neutral	2.74	neutral	-0.51	neutral	-1.34	low_impact	0.92	0.61	neutral	0.35	neutral	2.29	18.12	deleterious	0.34	0.55	0.26	neutral	0.23	neutral	0.31	neutral	0.39	neutral	2	0.99	deleterious	0.2	neutral	-2	neutral	0.66	deleterious	-2.64	low_impact	0.09	medium_impact	-0.25	medium_impact	0.80	0.9	2.14	6.81	0.51	P	0.35	disease_causing	0.89	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6462	6462	T	A	MI.3072	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	559	187	S	T	Tcc/Acc	3.83	1	0	probably_damaging	0.97	neutral	0.15	neutral	2.71	neutral	-0.88	neutral	-2.18	medium_impact	3.18	0.47	damaging	0.07	damaging	3.72	23.30	deleterious	0.3	0.55	0.3	neutral	0.64	disease	0.46	neutral	0.4	neutral	2	0.99	deleterious	0.09	neutral	1	deleterious	0.72	deleterious	-2.18	low_impact	-0.23	medium_impact	1.84	medium_impact	0.85	0.9	2.14	6.81	0.53	P	0.43	disease_causing	0.97	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6463	6463	C	T	MI.3073	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	560	187	S	F	tCc/tTc	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-2.02	deleterious	-4.59	high_impact	4.55	0.45	damaging	0.04	damaging	4.09	23.70	deleterious	0.17	0.55	0.75	disease	0.9	disease	0.58	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.43	0.9	2.14	6.81	0.5	P	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6463	6463	C	G	MI.3074	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	560	187	S	C	tCc/tGc	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-4.39	deleterious	-3.51	high_impact	3.65	0.46	damaging	0.04	damaging	3.47	23.00	deleterious	0.23	0.55	0.85	disease	0.83	disease	0.47	neutral	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.27	high_impact	0.75	0.9	2.14	6.81	0.42	N	0.85	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6463	6463	C	A	MI.3075	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	560	187	S	Y	tCc/tAc	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-1.2	deleterious	-4.59	high_impact	4.9	0.46	damaging	0.05	damaging	4.05	23.70	deleterious	0.17	0.55	0.53	disease	0.88	disease	0.59	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.43	high_impact	0.77	0.9	2.14	6.81	0.65	P	0.92	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6465	6465	G	A	MI.3076	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	562	188	V	I	Gtc/Atc	-20	0	0	benign	0.02	neutral	0.18	neutral	2.87	neutral	0.44	neutral	-0.58	neutral_impact	0.7	0.65	neutral	0.79	neutral	0.40	6.59	deleterious	0.56	0.6	0.16	neutral	0.3	neutral	0.27	neutral	0.39	neutral	2	0.81	neutral	0.58	deleterious	-6	neutral	0.14	neutral	0.83	medium_impact	-0.17	medium_impact	-0.45	medium_impact	0.96	1	13.06	21.55	0.51	N	0.04	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6465	6465	G	C	MI.3077	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	562	188	V	L	Gtc/Ctc	-20	0	0	benign	0.06	neutral	0.11	neutral	2.91	neutral	0.69	neutral	-2.27	medium_impact	2.87	0.59	damaging	0.54	neutral	1.65	14.11	neutral	0.45	0.55	0.28	neutral	0.8	disease	0.32	neutral	0.49	neutral	0	0.88	neutral	0.53	deleterious	-3	neutral	0.24	neutral	0.37	medium_impact	-0.31	medium_impact	1.55	medium_impact	0.70	0.9	13.06	21.55	0.47	N	0.49	polymorphism	0.96	0.04	rs28414181	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6465	6465	G	T	MI.3078	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	562	188	V	F	Gtc/Ttc	-20	0	0	possibly_damaging	0.87	deleterious	0	neutral	2.72	neutral	-0.94	deleterious	-3.99	high_impact	4.04	0.61	neutral	0.46	neutral	3.73	23.30	deleterious	0.28	0.55	0.58	disease	0.92	disease	0.56	disease	0.7	disease	4	1	deleterious	0.07	neutral	5	deleterious	0.77	deleterious	-1.53	low_impact	-1.48	low_impact	2.63	high_impact	0.80	0.9	13.06	21.55	0.39	N	0.87	polymorphism	0.71	0.13	rs28414181	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6466	6466	T	C	MI.3079	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	563	188	V	A	gTc/gCc	2.44	1	0	possibly_damaging	0.69	deleterious	0	neutral	2.84	neutral	0.27	deleterious	-3.35	high_impact	3.75	0.66	neutral	0.59	neutral	3.28	22.80	deleterious	0.39	0.55	0.46	neutral	0.67	disease	0.53	disease	0.54	disease	1	1	deleterious	0.16	neutral	5	deleterious	0.60	deleterious	-1.08	low_impact	-1.48	low_impact	2.36	high_impact	0.70	0.9	13.06	21.55	0.5	P	0.66	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8670	8670	A	T	MI.308	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	144	48	W	C	tgA/tgT	2.9	0.98	0	probably_damaging	1	neutral	0.18	neutral	4.27	deleterious	-3.14	deleterious	-11.03	medium_impact	3.26	0.93	neutral	0.54	neutral	3.99	23.60	deleterious	0.29	0.65	0.8	disease	0.87	disease	0.72	disease	0.8	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.08	medium_impact	1.7	medium_impact	0.22	0.9	19.47	20.58	0.52	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6466	6466	T	A	MI.3080	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	563	188	V	D	gTc/gAc	2.44	1	0	probably_damaging	0.99	deleterious	0	neutral	2.63	deleterious	-4.35	deleterious	-5.83	high_impact	4.73	0.64	neutral	0.46	neutral	4.42	24.20	deleterious	0.11	0.55	0.81	disease	0.91	disease	0.66	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.64	low_impact	-1.48	low_impact	3.27	high_impact	0.75	0.9	13.06	21.55	0.6	P	0.90	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6466	6466	T	G	MI.3081	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	563	188	V	G	gTc/gGc	2.44	1	0	probably_damaging	0.99	deleterious	0	neutral	2.64	deleterious	-3.2	deleterious	-5.94	high_impact	4.73	0.62	neutral	0.61	neutral	3.80	23.40	deleterious	0.22	0.55	0.71	disease	0.84	disease	0.55	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	3.27	high_impact	0.68	0.9	13.06	21.55	0.58	P	0.75	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6468	6468	C	G	MI.3082	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	565	189	L	V	Cta/Gta	-11.9	0	0	benign	0.18	neutral	0.09	neutral	2.56	neutral	-1.52	neutral	-0.84	low_impact	1.6	0.68	neutral	0.31	neutral	1.40	12.78	neutral	0.41	0.55	0.36	neutral	0.28	neutral	0.3	neutral	0.46	neutral	1	0.9	neutral	0.46	neutral	-6	neutral	0.24	neutral	-0.14	medium_impact	-0.37	medium_impact	0.38	medium_impact	0.58	0.9	8.58	17.61	0.45	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6468	6468	C	A	MI.3083	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	565	189	L	M	Cta/Ata	-11.9	0	0	benign	0.07	neutral	0.11	neutral	2.51	neutral	-2.02	neutral	-0.33	medium_impact	1.96	0.7	neutral	0.95	neutral	0.70	8.81	deleterious	0.3	0.55	0.5	disease	0.26	neutral	0.29	neutral	0.21	neutral	6	0.88	neutral	0.52	deleterious	-3	neutral	0.19	neutral	0.3	medium_impact	-0.31	medium_impact	0.71	medium_impact	0.58	0.9	8.58	17.61	0.5	P	0.05	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6469	6469	T	C	MI.3084	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	566	189	L	P	cTa/cCa	-4.96	0	0	possibly_damaging	0.72	deleterious	0.01	neutral	2.42	deleterious	-4.98	deleterious	-2.89	high_impact	3.71	0.6	neutral	0.1	damaging	2.65	20.50	deleterious	0.18	0.55	0.73	disease	0.82	disease	0.64	disease	0.72	disease	4	0.99	deleterious	0.15	neutral	5	deleterious	0.67	deleterious	-1.14	low_impact	-0.92	medium_impact	2.33	high_impact	0.56	0.9	8.58	17.61	0.25	N	0.82	disease_causing	0.74	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6469	6469	T	G	MI.3085	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	566	189	L	R	cTa/cGa	-4.96	0	0	possibly_damaging	0.65	deleterious	0.01	neutral	2.42	deleterious	-4.4	neutral	-2.12	high_impact	4.41	0.61	neutral	0.09	damaging	2.80	21.40	deleterious	0.17	0.55	0.73	disease	0.8	disease	0.64	disease	0.71	disease	4	0.99	deleterious	0.18	neutral	5	deleterious	0.66	deleterious	-1.01	low_impact	-0.92	medium_impact	2.97	high_impact	0.68	0.9	8.58	17.61	0.36	N	0.85	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6469	6469	T	A	MI.3086	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	566	189	L	Q	cTa/cAa	-4.96	0	0	possibly_damaging	0.72	deleterious	0.01	neutral	2.42	deleterious	-4.58	neutral	-2.1	high_impact	4.41	0.67	neutral	0.17	damaging	2.79	21.30	deleterious	0.2	0.55	0.74	disease	0.65	disease	0.5	neutral	0.5	neutral	0	0.99	deleterious	0.15	neutral	5	deleterious	0.62	deleterious	-1.14	low_impact	-0.92	medium_impact	2.97	high_impact	0.72	0.9	8.58	17.61	0.4	N	0.57	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6471	6471	A	C	MI.3087	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	568	190	I	L	Atc/Ctc	-0.33	0.13	0	benign	0.21	neutral	0.16	neutral	2.87	neutral	-0.34	neutral	-1.25	low_impact	1.5	0.62	neutral	0.63	neutral	2.62	20.30	deleterious	0.34	0.55	0.3	neutral	0.52	disease	0.32	neutral	0.44	neutral	1	0.81	neutral	0.48	deleterious	-6	neutral	0.19	neutral	-0.22	medium_impact	-0.21	medium_impact	0.29	medium_impact	0.40	0.9	5.85	29.77	0.49	N	0.61	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6471	6471	A	G	MI.3088	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	568	190	I	V	Atc/Gtc	-0.33	0.13	0	benign	0.01	neutral	0.64	neutral	2.9	neutral	0.39	neutral	-0.65	low_impact	1.07	0.72	neutral	0.9	neutral	1.76	14.76	neutral	0.54	0.6	0.18	neutral	0.14	neutral	0.28	neutral	0.23	neutral	5	0.34	neutral	0.82	deleterious	-6	neutral	0.12	neutral	1.12	medium_impact	0.33	medium_impact	-0.11	medium_impact	0.31	0.9	5.85	29.77	0.43	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6471	6471	A	T	MI.3089	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	568	190	I	F	Atc/Ttc	-0.33	0.13	0	possibly_damaging	0.8	neutral	0.13	neutral	2.79	neutral	-1.32	deleterious	-3.21	medium_impact	2.45	0.58	damaging	0.37	neutral	3.75	23.30	deleterious	0.3	0.55	0.57	disease	0.7	disease	0.38	neutral	0.52	disease	0	0.92	neutral	0.17	neutral	0	NA	0.70	deleterious	-1.32	low_impact	-0.27	medium_impact	1.16	medium_impact	0.49	0.9	5.85	29.77	0.38	N	0.85	polymorphism	0.62	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8670	8670	A	C	MI.309	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	144	48	W	C	tgA/tgC	2.9	0.98	0	probably_damaging	1	neutral	0.18	neutral	4.27	deleterious	-3.14	deleterious	-11.03	medium_impact	3.26	0.93	neutral	0.54	neutral	3.84	23.40	deleterious	0.29	0.65	0.8	disease	0.87	disease	0.72	disease	0.8	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.08	medium_impact	1.7	medium_impact	0.22	0.9	19.47	20.58	0.51	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6472	6472	T	C	MI.3090	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	569	190	I	T	aTc/aCc	3.14	0.99	0	possibly_damaging	0.79	deleterious	0.01	neutral	2.79	neutral	-0.53	deleterious	-3.86	medium_impact	3.38	0.62	neutral	0.49	neutral	3.45	23.00	deleterious	0.45	0.55	0.54	disease	0.54	disease	0.4	neutral	0.46	neutral	1	0.99	deleterious	0.11	neutral	4	deleterious	0.60	deleterious	-1.3	low_impact	-0.92	medium_impact	2.02	high_impact	0.49	0.9	5.85	29.77	0.49	P	0.76	disease_causing	0.97	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6472	6472	T	G	MI.3091	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	569	190	I	S	aTc/aGc	3.14	0.99	0	probably_damaging	0.93	deleterious	0	neutral	2.73	neutral	-1.93	deleterious	-4.83	high_impact	3.98	0.65	neutral	0.43	neutral	4.22	23.90	deleterious	0.32	0.55	0.71	disease	0.8	disease	0.54	disease	0.67	disease	3	1	deleterious	0.04	neutral	6	deleterious	0.73	deleterious	-1.81	low_impact	-1.48	low_impact	2.58	high_impact	0.38	0.9	5.85	29.77	0.44	N	0.62	disease_causing	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6472	6472	T	A	MI.3092	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	569	190	I	N	aTc/aAc	3.14	0.99	0	probably_damaging	0.98	deleterious	0	neutral	2.69	deleterious	-3.39	deleterious	-5.7	high_impact	3.75	0.64	neutral	0.42	neutral	4.53	24.30	deleterious	0.26	0.55	0.84	disease	0.77	disease	0.47	neutral	0.64	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.35	low_impact	-1.48	low_impact	2.36	high_impact	0.48	0.9	5.85	29.77	0.45	N	0.94	disease_causing	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6473	6473	C	G	MI.3093	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	570	190	I	M	atC/atG	7.53	1	0	probably_damaging	0.93	deleterious	0	neutral	2.75	neutral	-2.05	neutral	-2.12	high_impact	3.9	0.65	neutral	0.45	neutral	3.29	22.80	deleterious	0.37	0.55	0.66	disease	0.53	disease	0.48	neutral	0.49	neutral	0	1	deleterious	0.04	neutral	6	deleterious	0.67	deleterious	-1.81	low_impact	-1.48	low_impact	2.5	high_impact	0.61	0.9	5.85	29.77	0.53	P	0.76	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6473	6473	C	A	MI.3094	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	570	190	I	M	atC/atA	7.53	1	0	probably_damaging	0.93	deleterious	0	neutral	2.75	neutral	-2.05	neutral	-2.12	high_impact	3.9	0.65	neutral	0.45	neutral	3.71	23.30	deleterious	0.37	0.55	0.66	disease	0.53	disease	0.48	neutral	0.49	neutral	0	1	deleterious	0.04	neutral	6	deleterious	0.67	deleterious	-1.81	low_impact	-1.48	low_impact	2.5	high_impact	0.61	0.9	5.85	29.77	0.53	P	0.76	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6474	6474	A	G	MI.3095	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	571	191	T	A	Aca/Gca	-4.27	0	0	probably_damaging	0.99	deleterious	0	neutral	2.7	neutral	-0.55	deleterious	-4.35	high_impact	4.01	0.73	neutral	0.09	damaging	3.43	23.00	deleterious	0.4	0.55	0.42	neutral	0.62	disease	0.65	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.72	deleterious	-2.64	low_impact	-1.48	low_impact	2.6	high_impact	0.38	0.9	1.75	6.64	0.32	N	0.69	disease_causing	0.51	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6474	6474	A	T	MI.3096	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	571	191	T	S	Aca/Tca	-4.27	0	0	probably_damaging	0.99	deleterious	0	neutral	2.51	neutral	-2.36	deleterious	-3.48	high_impact	4.49	0.67	neutral	0.09	damaging	3.22	22.70	deleterious	0.37	0.55	0.58	disease	0.68	disease	0.65	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	3.05	high_impact	0.54	0.9	1.75	6.64	0.4	N	0.79	polymorphism	0.74	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6474	6474	A	C	MI.3097	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	571	191	T	P	Aca/Cca	-4.27	0	0	probably_damaging	1	deleterious	0	neutral	2.45	deleterious	-4.81	deleterious	-5.23	high_impact	4.95	0.55	damaging	0.08	damaging	3.43	23.00	deleterious	0.13	0.55	0.37	neutral	0.79	disease	0.78	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.43	0.9	1.75	6.64	0.61	P	0.92	disease_causing	0.84	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6475	6475	C	T	MI.3098	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	572	191	T	M	aCa/aTa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.49	neutral	-2.91	deleterious	-5.23	high_impact	4.74	0.69	neutral	0.07	damaging	4.01	23.60	deleterious	0.32	0.55	0.84	disease	0.77	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.28	high_impact	0.63	0.9	1.75	6.64	0.65	P	0.96	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6475	6475	C	A	MI.3099	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	572	191	T	K	aCa/aAa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-4.02	deleterious	-5.23	high_impact	5.29	0.6	damaging	0.07	damaging	4.44	24.20	deleterious	0.13	0.55	0.67	disease	0.84	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.64	0.9	1.75	6.64	0.75	P	0.88	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8539	8539	C	A	MI.31	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	13	5	L	M	Ctg/Atg	-0.33	0	0	probably_damaging	0.99	neutral	0.05	neutral	4.17	neutral	-2.57	neutral	-1.38	medium_impact	1.96	0.79	neutral	0.59	neutral	3.74	23.30	deleterious	0.31	0.65	0.57	disease	0.21	neutral	0.31	neutral	0.46	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.69	deleterious	-2.65	low_impact	-0.43	medium_impact	0.58	medium_impact	0.65	0.9	50.44	8.42	0.44	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8671	8671	C	A	MI.310	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	145	49	L	M	Cta/Ata	0.13	0.01	0	probably_damaging	1	neutral	0.2	neutral	4.11	neutral	-2.66	neutral	-0.97	low_impact	1.6	0.83	neutral	0.76	neutral	2.50	19.45	deleterious	0.22	0.65	0.78	disease	0.35	neutral	0.24	neutral	0.66	disease	3	1	deleterious	0.1	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	-0.05	medium_impact	0.27	medium_impact	0.74	0.9	44.25	12.31	0.43	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6477	6477	G	C	MI.3100	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	574	192	A	P	Gca/Cca	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-3.32	deleterious	-3.85	high_impact	4.84	0.58	damaging	0.05	damaging	3.80	23.40	deleterious	0.1	0.55	0.69	disease	0.82	disease	0.65	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.65	0.9	2.14	6.81	0.62	P	0.85	polymorphism	0.7	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6477	6477	G	T	MI.3101	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	574	192	A	S	Gca/Tca	-4.5	0	0	possibly_damaging	0.84	neutral	0.22	neutral	2.73	neutral	-0.45	neutral	-2.25	low_impact	1.42	0.65	neutral	0.06	damaging	3.26	22.80	deleterious	0.35	0.55	0.2	neutral	0.62	disease	0.27	neutral	0.35	neutral	3	0.9	neutral	0.19	neutral	-3	neutral	0.45	deleterious	-1.43	low_impact	-0.11	medium_impact	0.21	medium_impact	0.63	0.9	2.14	6.81	0.28	N	0.64	polymorphism	0.95	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6477	6477	G	A	MI.3102	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	574	192	A	T	Gca/Aca	-4.5	0	0	possibly_damaging	0.67	neutral	0.1	neutral	2.54	neutral	-2.65	deleterious	-2.58	low_impact	1.46	0.59	damaging	0.14	damaging	2.77	21.20	deleterious	0.37	0.55	0.35	neutral	0.49	neutral	0.33	neutral	0.4	neutral	2	0.91	neutral	0.22	neutral	-3	neutral	0.56	deleterious	-1.05	low_impact	-0.34	medium_impact	0.25	medium_impact	0.55	0.9	2.14	6.81	0.33	N	0.20	polymorphism	0.89	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6478	6478	C	G	MI.3103	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	575	192	A	G	gCa/gGa	6.14	1	0	possibly_damaging	0.73	deleterious	0	neutral	2.53	neutral	-2.92	deleterious	-3.21	medium_impact	3.48	0.64	neutral	0.11	damaging	1.89	15.50	deleterious	0.26	0.55	0.51	disease	0.64	disease	0.51	disease	0.47	neutral	1	1	deleterious	0.14	neutral	4	deleterious	0.49	deleterious	-1.16	low_impact	-1.48	low_impact	2.11	high_impact	0.64	0.9	2.14	6.81	0.51	N	0.56	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6478	6478	C	A	MI.3104	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	575	192	A	E	gCa/gAa	6.14	1	0	probably_damaging	0.99	deleterious	0	neutral	2.52	deleterious	-3.52	deleterious	-3.84	high_impact	4.49	0.64	neutral	0.06	damaging	4.43	24.20	deleterious	0.12	0.55	0.53	disease	0.84	disease	0.66	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.64	low_impact	-1.48	low_impact	3.05	high_impact	0.61	0.9	2.14	6.81	0.5	P	0.76	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6478	6478	C	T	MI.3105	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	575	192	A	V	gCa/gTa	6.14	1	0	benign	0.05	neutral	0.23	neutral	2.58	neutral	-1.84	deleterious	-2.62	medium_impact	2.29	0.64	neutral	0.09	damaging	3.02	22.30	deleterious	0.35	0.55	0.31	neutral	0.61	disease	0.36	neutral	0.36	neutral	3	0.75	neutral	0.59	deleterious	-3	neutral	0.21	neutral	0.45	medium_impact	-0.1	medium_impact	1.02	medium_impact	0.60	0.9	2.14	6.81	0.52	P	0.75	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6480	6480	G	A	MI.3106	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	577	193	V	I	Gtc/Atc	-9.36	0	0.01	benign	0	neutral	0.72	neutral	2.87	neutral	0.37	neutral	0.35	neutral_impact	-1.02	0.75	neutral	0.92	neutral	-1.10	0.01	neutral	0.52	0.6	0.18	neutral	0.08	neutral	0.19	neutral	0.26	neutral	5	0.28	neutral	0.86	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.42	medium_impact	-2.04	low_impact	0.76	0.9	11.7	20.86	0.42	N	0.04	disease_causing_automatic	0	0.01	rs199476128	Pathogenic	Hepatic_failure,_early-onset,_and_neurologic_disorder_due_to_cytochrome_C_oxidase_deficiency	24705	MedGen:C0268237,OMIM:220110,Orphanet:ORPHA254905,SNOMED_CT:67434000	.	.	.	5.49	G6480A	Prostate Cancer / enriched in POAG cohort	+	-	Reported	4	P	P	P	neutral
chrM	6480	6480	G	T	MI.3107	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	577	193	V	F	Gtc/Ttc	-9.36	0	0.01	possibly_damaging	0.53	neutral	0.83	neutral	2.69	neutral	-1.02	neutral	-1.74	neutral_impact	0.2	0.65	neutral	0.63	neutral	0.63	8.40	deleterious	0.27	0.55	0.34	neutral	0.42	neutral	0.18	neutral	0.47	neutral	1	0.44	neutral	0.65	deleterious	-3	neutral	0.54	deleterious	-0.81	medium_impact	0.58	medium_impact	-0.91	medium_impact	0.58	0.9	11.7	20.86	0.35	N	0.87	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6480	6480	G	C	MI.3108	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	577	193	V	L	Gtc/Ctc	-9.36	0	0.01	benign	0.01	neutral	0.34	neutral	2.81	neutral	0.03	neutral	-0.4	neutral_impact	0.28	0.67	neutral	0.63	neutral	-0.21	1.07	neutral	0.39	0.55	0.32	neutral	0.32	neutral	0.22	neutral	0.47	neutral	1	0.65	neutral	0.67	deleterious	-6	neutral	0.15	neutral	1.12	medium_impact	0.03	medium_impact	-0.84	medium_impact	0.53	0.9	11.7	20.86	0.49	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6481	6481	T	G	MI.3109	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	578	193	V	G	gTc/gGc	2.44	0.99	0	possibly_damaging	0.73	deleterious	0	neutral	2.62	neutral	-2.34	deleterious	-5.09	low_impact	1.75	0.61	neutral	0.61	neutral	1.87	15.39	deleterious	0.23	0.55	0.67	disease	0.57	disease	0.38	neutral	0.48	neutral	0	1	deleterious	0.14	neutral	1	deleterious	0.68	deleterious	-1.16	low_impact	-1.48	low_impact	0.52	medium_impact	0.49	0.9	11.7	20.86	0.46	N	0.75	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8671	8671	C	G	MI.311	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	145	49	L	V	Cta/Gta	0.13	0.01	0	probably_damaging	0.99	neutral	0.23	neutral	4.42	neutral	0.14	neutral	-1.89	low_impact	1.07	0.89	neutral	0.68	neutral	2.22	17.67	deleterious	0.28	0.65	0.65	disease	0.4	neutral	0.41	neutral	0.62	disease	2	0.99	deleterious	0.12	neutral	-2	neutral	0.76	deleterious	-2.65	low_impact	-0.01	medium_impact	-0.18	medium_impact	0.68	0.9	44.25	12.31	0.43	N	0.69	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6481	6481	T	C	MI.3110	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	578	193	V	A	gTc/gCc	2.44	0.99	0	benign	0.26	deleterious	0	neutral	2.73	neutral	-0.55	deleterious	-2.72	medium_impact	2.22	0.64	neutral	0.54	neutral	1.61	13.93	neutral	0.36	0.55	0.38	neutral	0.41	neutral	0.36	neutral	0.47	neutral	1	1	deleterious	0.37	neutral	1	deleterious	0.35	neutral	-0.33	medium_impact	-1.48	low_impact	0.95	medium_impact	0.38	0.9	11.7	20.86	0.56	P	0.66	disease_causing	0.97	0.11	rs28721398	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6481	6481	T	A	MI.3111	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	578	193	V	D	gTc/gAc	2.44	0.99	0	possibly_damaging	0.74	deleterious	0	neutral	2.57	deleterious	-4.74	deleterious	-4.78	high_impact	3.54	0.58	damaging	0.42	neutral	2.76	21.20	deleterious	0.14	0.55	0.8	disease	0.79	disease	0.58	disease	0.76	disease	5	1	deleterious	0.13	neutral	5	deleterious	0.74	deleterious	-1.18	low_impact	-1.48	low_impact	2.17	high_impact	0.52	0.9	11.7	20.86	0.46	P	0.90	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6483	6483	C	G	MI.3112	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	580	194	L	V	Cta/Gta	-10.28	0	0	probably_damaging	0.99	deleterious	0	neutral	2.46	neutral	-2.13	deleterious	-2.6	high_impact	4.93	0.47	damaging	0.06	damaging	3.35	22.90	deleterious	0.32	0.55	0.52	disease	0.59	disease	0.61	disease	0.64	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	3.45	high_impact	0.40	0.9	3.12	6.73	0.54	P	0.66	polymorphism	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6483	6483	C	A	MI.3113	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	580	194	L	M	Cta/Ata	-10.28	0	0	probably_damaging	1	deleterious	0.03	neutral	2.46	neutral	-2.19	neutral	-1.72	high_impact	3.56	0.44	damaging	0.11	damaging	3.66	23.20	deleterious	0.26	0.55	0.39	neutral	0.52	disease	0.38	neutral	0.33	neutral	3	1	deleterious	0.02	neutral	6	deleterious	0.72	deleterious	-3.58	low_impact	-0.65	medium_impact	2.19	high_impact	0.40	0.9	3.12	6.73	0.37	N	0.59	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6484	6484	T	A	MI.3114	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	581	194	L	Q	cTa/cAa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.36	deleterious	-4.91	deleterious	-5.2	high_impact	4.72	0.5	damaging	0.04	damaging	4.02	23.60	deleterious	0.14	0.55	0.84	disease	0.79	disease	0.61	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.44	0.9	3.12	6.73	0.53	P	0.82	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6484	6484	T	C	MI.3115	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	581	194	L	P	cTa/cCa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.36	deleterious	-5.3	deleterious	-6.08	high_impact	4.72	0.35	damaging	0.04	damaging	3.84	23.40	deleterious	0.18	0.55	0.79	disease	0.79	disease	0.72	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.43	0.9	3.12	6.73	0.58	P	0.83	disease_causing	0.98	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6484	6484	T	G	MI.3116	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	581	194	L	R	cTa/cGa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.36	deleterious	-4.74	deleterious	-5.21	high_impact	5.28	0.47	damaging	0.03	damaging	4.15	23.80	deleterious	0.16	0.55	0.83	disease	0.86	disease	0.73	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.32	0.9	3.12	6.73	0.59	P	0.90	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6486	6486	C	G	MI.3117	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	583	195	L	V	Ctt/Gtt	-20	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.69	neutral	-0.94	deleterious	-2.61	medium_impact	3.29	0.35	damaging	0.32	neutral	3.39	23.00	deleterious	0.32	0.55	0.36	neutral	0.56	disease	0.51	disease	0.43	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-2.64	low_impact	-0.92	medium_impact	1.94	medium_impact	0.39	0.9	6.63	7.85	0.52	P	0.66	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6486	6486	C	A	MI.3118	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	583	195	L	I	Ctt/Att	-20	0	0	probably_damaging	1	deleterious	0.01	neutral	2.79	neutral	-0.11	neutral	-1.74	medium_impact	3.03	0.45	damaging	0.46	neutral	4.08	23.70	deleterious	0.28	0.55	0.31	neutral	0.62	disease	0.46	neutral	0.4	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-0.92	medium_impact	1.7	medium_impact	0.52	0.9	6.63	7.85	0.47	N	0.54	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6486	6486	C	T	MI.3119	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	583	195	L	F	Ctt/Ttt	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-0.89	deleterious	-3.48	high_impact	5.22	0.42	damaging	0.32	neutral	3.92	23.50	deleterious	0.26	0.55	0.62	disease	0.71	disease	0.58	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.36	0.9	6.63	7.85	0.6	P	0.87	polymorphism	0.96	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8672	8672	T	G	MI.312	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	146	49	L	R	cTa/cGa	-6.35	0	0	probably_damaging	1	deleterious	0.03	neutral	4.06	deleterious	-4.85	deleterious	-4.25	medium_impact	3.17	0.75	neutral	0.1	damaging	4.05	23.70	deleterious	0.08	0.65	0.9	disease	0.85	disease	0.67	disease	0.81	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.90	deleterious	-3.6	low_impact	-0.56	medium_impact	1.62	medium_impact	0.54	0.9	44.25	12.31	0.25	N	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6487	6487	T	G	MI.3120	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	584	195	L	R	cTt/cGt	1.05	0.47	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.59	deleterious	-5.23	high_impact	5.22	0.49	damaging	0.26	damaging	4.20	23.90	deleterious	0.16	0.55	0.74	disease	0.86	disease	0.71	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.39	0.9	6.63	7.85	0.64	P	0.90	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6487	6487	T	C	MI.3121	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	584	195	L	P	cTt/cCt	1.05	0.47	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-4.18	deleterious	-6.1	high_impact	4.87	0.39	damaging	0.29	neutral	3.89	23.50	deleterious	0.18	0.55	0.81	disease	0.8	disease	0.71	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.4	high_impact	0.48	0.9	6.63	7.85	0.72	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6487	6487	T	A	MI.3122	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	584	195	L	H	cTt/cAt	1.05	0.47	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-4.13	deleterious	-6.1	high_impact	5.22	0.5	damaging	0.27	damaging	4.20	23.90	deleterious	0.14	0.55	0.8	disease	0.8	disease	0.67	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.34	0.9	6.63	7.85	0.59	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6489	6489	C	G	MI.3123	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	586	196	L	V	Ctc/Gtc	-15.6	0	0	probably_damaging	0.99	neutral	0.17	neutral	2.61	neutral	-1.15	neutral	-2.33	medium_impact	2.4	0.35	damaging	0.33	neutral	3.40	23.00	deleterious	0.39	0.55	0.3	neutral	0.5	neutral	0.25	neutral	0.41	neutral	2	1	deleterious	0.09	neutral	1	deleterious	0.71	deleterious	-2.64	low_impact	-0.19	medium_impact	1.12	medium_impact	0.43	0.9	6.82	7.94	0.53	P	0.66	disease_causing_automatic	0.01	0.13	rs28461189	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	6489	6489	C	A	MI.3124	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	586	196	L	I	Ctc/Atc	-15.6	0	0	probably_damaging	1	neutral	0.13	neutral	2.67	neutral	-1.31	neutral	-1.5	medium_impact	2.15	0.19	damaging	0.47	neutral	4.04	23.70	deleterious	0.29	0.55	0.37	neutral	0.52	disease	0.23	neutral	0.41	neutral	2	1	deleterious	0.07	neutral	1	deleterious	0.73	deleterious	-3.58	low_impact	-0.27	medium_impact	0.89	medium_impact	0.57	0.9	6.82	7.94	0.81	P	0.54	disease_causing_automatic	0	0.04	rs28461189	Pathogenic	Cytochrome_c_oxidase_i_deficiency	24709	MedGen:CN069330	.	.	CPD	0.15	C6489A	Therapy-Resistant Epilepsy	-	+	Reported	2	P	P	P	damaging
chrM	6489	6489	C	T	MI.3125	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	586	196	L	F	Ctc/Ttc	-15.6	0	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-3.18	deleterious	-3.35	high_impact	4.43	0.32	damaging	0.35	neutral	3.96	23.60	deleterious	0.32	0.55	0.62	disease	0.72	disease	0.48	neutral	0.5	disease	0	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.99	high_impact	0.36	0.9	6.82	7.94	0.56	P	0.87	polymorphism	0.96	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6490	6490	T	A	MI.3126	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	587	196	L	H	cTc/cAc	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-5.02	deleterious	-5.94	high_impact	5.12	0.41	damaging	0.31	neutral	4.01	23.60	deleterious	0.15	0.55	0.79	disease	0.82	disease	0.58	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.35	0.9	6.82	7.94	0.65	P	0.83	disease_causing	0.99	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6490	6490	T	G	MI.3127	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	587	196	L	R	cTc/cGc	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-4.48	deleterious	-5.13	high_impact	5.12	0.41	damaging	0.26	damaging	4.09	23.70	deleterious	0.14	0.55	0.36	neutral	0.88	disease	0.63	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.38	0.9	6.82	7.94	0.63	P	0.90	disease_causing	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6490	6490	T	C	MI.3128	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	587	196	L	P	cTc/cCc	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-5.06	deleterious	-5.92	high_impact	5.12	0.32	damaging	0.29	neutral	3.83	23.40	deleterious	0.15	0.55	0.8	disease	0.83	disease	0.63	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.50	0.9	6.82	7.94	0.69	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6492	6492	C	G	MI.3129	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	589	197	L	V	Cta/Gta	-20	0	0	probably_damaging	0.97	neutral	0.09	neutral	2.78	neutral	-1.13	deleterious	-2.54	medium_impact	3.11	0.56	damaging	0.06	damaging	3.37	22.90	deleterious	0.5	0.55	0.26	neutral	0.65	disease	0.32	neutral	0.34	neutral	3	0.99	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-2.18	low_impact	-0.37	medium_impact	1.77	medium_impact	0.52	0.9	3.31	7.25	0.31	N	0.66	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8672	8672	T	A	MI.313	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	146	49	L	Q	cTa/cAa	-6.35	0	0	probably_damaging	1	deleterious	0.03	neutral	4.06	deleterious	-4.97	deleterious	-4.21	medium_impact	2.82	0.8	neutral	0.16	damaging	4.06	23.70	deleterious	0.11	0.65	0.91	disease	0.7	disease	0.54	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-3.6	low_impact	-0.56	medium_impact	1.32	medium_impact	0.48	0.9	44.25	12.31	0.27	N	0.94	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6492	6492	C	A	MI.3130	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	589	197	L	M	Cta/Ata	-20	0	0	probably_damaging	1	deleterious	0.02	neutral	2.6	neutral	-2.81	neutral	-1.7	high_impact	3.57	0.57	damaging	0.09	damaging	3.70	23.30	deleterious	0.31	0.55	0.63	disease	0.63	disease	0.31	neutral	0.34	neutral	3	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-0.75	medium_impact	2.2	high_impact	0.44	0.9	3.31	7.25	0.28	N	0.59	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6493	6493	T	C	MI.3131	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	590	197	L	P	cTa/cCa	0.36	0.06	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-4.78	deleterious	-5.99	high_impact	4.59	0.46	damaging	0.05	damaging	3.89	23.50	deleterious	0.17	0.55	0.7	disease	0.85	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.14	high_impact	0.45	0.9	3.31	7.25	0.43	N	0.83	disease_causing	0.98	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6493	6493	T	G	MI.3132	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	590	197	L	R	cTa/cGa	0.36	0.06	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-4.21	deleterious	-5.13	high_impact	5.14	0.53	damaging	0.04	damaging	4.17	23.80	deleterious	0.17	0.55	0.78	disease	0.9	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.49	0.9	3.31	7.25	0.62	P	0.90	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6493	6493	T	A	MI.3133	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	590	197	L	Q	cTa/cAa	0.36	0.06	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-4.39	deleterious	-5.13	high_impact	5.14	0.55	damaging	0.05	damaging	4.05	23.70	deleterious	0.2	0.55	0.79	disease	0.83	disease	0.54	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.57	0.9	3.31	7.25	0.59	P	0.82	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6495	6495	T	G	MI.3134	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	592	198	S	A	Tct/Gct	-12.83	0	0	probably_damaging	0.99	neutral	0.09	neutral	2.95	neutral	-0.32	neutral	-2.37	low_impact	1.88	0.58	damaging	0.8	neutral	2.56	19.86	deleterious	0.44	0.55	0.16	neutral	0.42	neutral	0.32	neutral	0.39	neutral	2	0.99	deleterious	0.05	neutral	-2	neutral	0.67	deleterious	-2.64	low_impact	-0.37	medium_impact	0.64	medium_impact	0.61	0.9	9.55	8.54	0.43	N	0.35	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6495	6495	T	C	MI.3135	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	592	198	S	P	Tct/Cct	-12.83	0	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.33	deleterious	-4.23	high_impact	5.11	0.47	damaging	0.5	neutral	3.92	23.50	deleterious	0.24	0.55	0.66	disease	0.86	disease	0.7	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.63	0.9	9.55	8.54	0.68	P	0.91	polymorphism	0.97	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6495	6495	T	A	MI.3136	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	592	198	S	T	Tct/Act	-12.83	0	0	probably_damaging	0.97	deleterious	0	neutral	2.84	neutral	-1.28	deleterious	-2.52	medium_impact	3.27	0.52	damaging	0.51	neutral	3.78	23.40	deleterious	0.33	0.55	0.28	neutral	0.56	disease	0.38	neutral	0.36	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.71	deleterious	-2.18	low_impact	-1.48	low_impact	1.92	medium_impact	0.66	0.9	9.55	8.54	0.47	N	0.43	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6496	6496	C	A	MI.3137	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	593	198	S	Y	tCt/tAt	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.76	deleterious	-3.08	deleterious	-5.09	high_impact	5.11	0.48	damaging	0.41	neutral	4.07	23.70	deleterious	0.22	0.55	0.57	disease	0.85	disease	0.6	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.60	0.9	9.55	8.54	0.69	P	0.92	disease_causing	1	0.34	.	.	.	.	.	.	COSM5656133	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6496	6496	C	G	MI.3138	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	593	198	S	C	tCt/tGt	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.74	deleterious	-4.22	deleterious	-4.19	high_impact	4.3	0.49	damaging	0.44	neutral	3.51	23.10	deleterious	0.3	0.55	0.68	disease	0.78	disease	0.49	neutral	0.61	disease	2	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.87	high_impact	0.57	0.9	9.55	8.54	0.5	P	0.85	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6496	6496	C	T	MI.3139	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	593	198	S	F	tCt/tTt	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-2.97	deleterious	-5.09	high_impact	4.42	0.43	damaging	0.43	neutral	4.10	23.70	deleterious	0.2	0.55	0.5	disease	0.88	disease	0.6	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.35	0.9	9.55	8.54	0.69	P	0.98	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8672	8672	T	C	MI.314	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	146	49	L	P	cTa/cCa	-6.35	0	0	probably_damaging	1	neutral	0.09	neutral	4.05	deleterious	-5.31	deleterious	-5.13	low_impact	1.92	0.71	neutral	0.11	damaging	3.81	23.40	deleterious	0.1	0.65	0.93	disease	0.87	disease	0.66	disease	0.83	disease	7	1	deleterious	0.05	neutral	-2	neutral	0.91	deleterious	-3.6	low_impact	-0.28	medium_impact	0.55	medium_impact	0.52	0.9	44.25	12.31	0.21	N	0.85	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6498	6498	C	A	MI.3140	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	595	199	L	I	Ctc/Atc	-11.67	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-1.42	neutral	-1.57	medium_impact	3.28	0.25	damaging	0.47	neutral	4.05	23.70	deleterious	0.42	0.55	0.31	neutral	0.66	disease	0.33	neutral	0.47	neutral	1	1	deleterious	0	neutral	5	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	1.93	medium_impact	0.76	0.9	2.53	6.72	0.85	P	0.54	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6498	6498	C	G	MI.3141	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	595	199	L	V	Ctc/Gtc	-11.67	0	0	probably_damaging	0.99	deleterious	0.04	neutral	2.68	neutral	-1.38	neutral	-2.43	medium_impact	3.47	0.29	damaging	0.35	neutral	3.44	23.00	deleterious	0.4	0.55	0.29	neutral	0.61	disease	0.49	neutral	0.44	neutral	1	1	deleterious	0.03	neutral	5	deleterious	0.73	deleterious	-2.64	low_impact	-0.58	medium_impact	2.11	high_impact	0.62	0.9	2.53	6.72	0.78	P	0.66	polymorphism	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6498	6498	C	T	MI.3142	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	595	199	L	F	Ctc/Ttc	-11.67	0	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-0.15	deleterious	-3.38	medium_impact	3	0.32	damaging	0.32	neutral	3.96	23.60	deleterious	0.4	0.55	0.27	neutral	0.74	disease	0.5	neutral	0.52	disease	0	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	1.67	medium_impact	0.60	0.9	2.53	6.72	0.56	P	0.87	polymorphism	0.89	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6499	6499	T	A	MI.3143	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	596	199	L	H	cTc/cAc	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-4.44	deleterious	-5.98	high_impact	5.17	0.43	damaging	0.29	neutral	4.07	23.70	deleterious	0.18	0.55	0.76	disease	0.83	disease	0.67	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.54	0.9	2.53	6.72	0.66	P	0.83	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6499	6499	T	C	MI.3144	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	596	199	L	P	cTc/cCc	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-4.49	deleterious	-5.98	high_impact	5.17	0.36	damaging	0.45	neutral	3.85	23.40	deleterious	0.15	0.55	0.76	disease	0.83	disease	0.71	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.58	0.9	2.53	6.72	0.73	P	0.83	disease_causing	0.87	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6499	6499	T	G	MI.3145	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	596	199	L	R	cTc/cGc	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-3.89	deleterious	-5.15	high_impact	5.17	0.42	damaging	0.27	damaging	4.14	23.80	deleterious	0.16	0.55	0.69	disease	0.9	disease	0.72	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.58	0.9	2.53	6.72	0.69	P	0.90	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6501	6501	C	T	MI.3146	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	598	200	P	S	Cca/Tca	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.4	neutral	-2.91	deleterious	-6.92	high_impact	5.31	0.67	neutral	0.06	damaging	3.85	23.40	deleterious	0.4	0.55	0.67	disease	0.8	disease	0.67	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.16	0.9	2.73	7.82	0.56	P	0.85	polymorphism	0.89	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6501	6501	C	A	MI.3147	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	598	200	P	T	Cca/Aca	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.38	deleterious	-3.11	deleterious	-6.92	high_impact	4.62	0.66	neutral	0.06	damaging	3.65	23.20	deleterious	0.3	0.55	0.74	disease	0.72	disease	0.65	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.52	0.9	2.73	7.82	0.39	N	0.80	polymorphism	0.89	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6501	6501	C	G	MI.3148	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	598	200	P	A	Cca/Gca	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.46	neutral	-2.35	deleterious	-6.92	high_impact	5.31	0.68	neutral	0.07	damaging	3.05	22.40	deleterious	0.25	0.55	0.63	disease	0.62	disease	0.68	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.62	0.9	2.73	7.82	0.56	P	0.76	polymorphism	0.93	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6502	6502	C	G	MI.3149	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	599	200	P	R	cCa/cGa	4.52	1	0	probably_damaging	1	deleterious	0	neutral	2.36	deleterious	-4.06	deleterious	-7.8	high_impact	4.96	0.63	neutral	0.05	damaging	3.56	23.10	deleterious	0.19	0.55	0.89	disease	0.89	disease	0.8	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.49	0.9	2.73	7.82	0.65	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8674	8674	A	G	MI.315	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	148	50	I	V	Atc/Gtc	-2.88	0	0	benign	0.05	neutral	0.3	neutral	4.47	neutral	0.53	neutral	-0.33	low_impact	1.33	0.92	neutral	0.98	neutral	-0.30	0.67	neutral	0.64	0.7	0.34	neutral	0.18	neutral	0.26	neutral	0.29	neutral	4	0.68	neutral	0.63	deleterious	-6	neutral	0.14	neutral	0.46	medium_impact	0.08	medium_impact	0.04	medium_impact	0.50	0.9	17.7	19.1	0.44	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6502	6502	C	A	MI.3150	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	599	200	P	Q	cCa/cAa	4.52	1	0	probably_damaging	1	deleterious	0	neutral	2.36	deleterious	-4	deleterious	-6.93	high_impact	4.96	0.67	neutral	0.04	damaging	4.08	23.70	deleterious	0.2	0.55	0.89	disease	0.85	disease	0.71	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.51	0.9	2.73	7.82	0.65	P	0.82	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6502	6502	C	T	MI.3151	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	599	200	P	L	cCa/cTa	4.52	1	0	probably_damaging	1	deleterious	0.02	neutral	2.51	neutral	-1.9	deleterious	-8.66	high_impact	4.62	0.68	neutral	0.03	damaging	4.39	24.10	deleterious	0.32	0.55	0.86	disease	0.87	disease	0.65	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-0.75	medium_impact	3.17	high_impact	0.75	0.9	2.73	7.82	0.58	P	0.87	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6504	6504	G	C	MI.3152	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	601	201	V	L	Gtc/Ctc	-2.19	0	0	probably_damaging	0.99	deleterious	0	neutral	2.7	neutral	-1.7	deleterious	-2.54	high_impact	3.68	0.61	neutral	0.13	damaging	3.62	23.20	deleterious	0.4	0.55	0.76	disease	0.76	disease	0.6	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	2.3	high_impact	0.39	0.9	3.51	7.98	0.28	N	0.55	disease_causing	0.51	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6504	6504	G	A	MI.3153	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	601	201	V	I	Gtc/Atc	-2.19	0	0	probably_damaging	0.99	deleterious	0.02	neutral	2.71	neutral	-1.64	neutral	-0.82	medium_impact	2.9	0.56	damaging	0.18	damaging	3.62	23.20	deleterious	0.52	0.6	0.78	disease	0.56	disease	0.52	disease	0.51	disease	0	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-2.64	low_impact	-0.75	medium_impact	1.58	medium_impact	0.68	0.9	3.51	7.98	0.33	N	0.24	polymorphism	0.77	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6504	6504	G	T	MI.3154	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	601	201	V	F	Gtc/Ttc	-2.19	0	0	probably_damaging	1	deleterious	0.02	neutral	2.62	deleterious	-3.39	deleterious	-4.25	high_impact	4.54	0.57	damaging	0.11	damaging	3.86	23.50	deleterious	0.17	0.55	0.88	disease	0.87	disease	0.65	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.75	medium_impact	3.09	high_impact	0.50	0.9	3.51	7.98	0.41	N	0.86	disease_causing	0.92	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6505	6505	T	A	MI.3155	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	602	201	V	D	gTc/gAc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-4.82	deleterious	-5.99	high_impact	4.33	0.67	neutral	0.12	damaging	4.65	24.50	deleterious	0.1	0.55	0.89	disease	0.88	disease	0.74	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.9	high_impact	0.49	0.9	3.51	7.98	0.56	P	0.83	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6505	6505	T	G	MI.3156	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	602	201	V	G	gTc/gGc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-2.25	deleterious	-6	high_impact	4.68	0.61	neutral	0.17	damaging	3.79	23.40	deleterious	0.17	0.55	0.64	disease	0.77	disease	0.63	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.48	0.9	3.51	7.98	0.59	P	0.71	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6505	6505	T	C	MI.3157	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	602	201	V	A	gTc/gCc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-1.33	deleterious	-3.42	high_impact	4.19	0.52	damaging	0.18	damaging	3.60	23.20	deleterious	0.37	0.55	0.62	disease	0.58	disease	0.61	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.77	high_impact	0.28	0.9	3.51	7.98	0.6	P	0.47	disease_causing	1	0.17	rs28371932	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6507	6507	C	G	MI.3158	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	604	202	L	V	Cta/Gta	-12.83	0	0	probably_damaging	0.99	deleterious	0	neutral	2.54	neutral	-2.15	deleterious	-2.6	high_impact	4.22	0.43	damaging	0.15	damaging	3.39	23.00	deleterious	0.34	0.55	0.55	disease	0.53	disease	0.51	disease	0.52	disease	0	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.8	high_impact	0.61	0.9	3.51	7.17	0.43	N	0.66	polymorphism	0.99	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6507	6507	C	A	MI.3159	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	604	202	L	M	Cta/Ata	-12.83	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.69	neutral	-1.73	high_impact	4.17	0.6	neutral	0.17	damaging	3.71	23.30	deleterious	0.27	0.55	0.77	disease	0.58	disease	0.51	disease	0.54	disease	1	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.75	high_impact	0.63	0.9	3.51	7.17	0.35	N	0.59	polymorphism	0.99	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8674	8674	A	C	MI.316	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	148	50	I	L	Atc/Ctc	-2.88	0	0	benign	0.05	neutral	1	neutral	4.43	neutral	0.29	neutral	-1.26	low_impact	1	0.9	neutral	0.95	neutral	0.35	6.16	deleterious	0.44	0.65	0.41	neutral	0.22	neutral	0.19	neutral	0.43	neutral	2	0.05	neutral	0.98	deleterious	-6	neutral	0.17	neutral	0.46	medium_impact	1.98	high_impact	-0.24	medium_impact	0.73	0.9	17.7	19.1	0.38	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6508	6508	T	C	MI.3160	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	605	202	L	P	cTa/cCa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-6.79	deleterious	-6.07	high_impact	4.22	0.45	damaging	0.13	damaging	3.90	23.50	deleterious	0.17	0.55	0.96	disease	0.76	disease	0.7	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.8	high_impact	0.48	0.9	3.51	7.17	0.32	N	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6508	6508	T	A	MI.3161	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	605	202	L	Q	cTa/cAa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	2.41	deleterious	-6.38	deleterious	-5.2	high_impact	5.26	0.53	damaging	0.12	damaging	4.06	23.70	deleterious	0.16	0.55	0.95	disease	0.77	disease	0.62	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.58	0.9	3.51	7.17	0.55	P	0.82	polymorphism	0.95	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6508	6508	T	G	MI.3162	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	605	202	L	R	cTa/cGa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-6.26	deleterious	-5.2	high_impact	5.26	0.54	damaging	0.11	damaging	4.16	23.80	deleterious	0.16	0.55	0.96	disease	0.85	disease	0.74	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.41	0.9	3.51	7.17	0.58	P	0.90	polymorphism	0.94	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6510	6510	G	C	MI.3163	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	607	203	A	P	Gct/Cct	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.47	deleterious	-4.34	high_impact	5.25	0.51	damaging	0.08	damaging	3.78	23.40	deleterious	0.15	0.55	0.74	disease	0.81	disease	0.71	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.61	0.9	4.68	6.73	0.62	P	0.85	disease_causing	0.98	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6510	6510	G	A	MI.3164	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	607	203	A	T	Gct/Act	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-1.79	deleterious	-3.46	medium_impact	3.36	0.62	neutral	0.08	damaging	4.19	23.80	deleterious	0.27	0.55	0.25	neutral	0.65	disease	0.49	neutral	0.5	neutral	0	1	deleterious	0	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-1.48	low_impact	2	high_impact	0.68	0.9	4.68	6.73	0.32	N	0.20	disease_causing	0.93	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6510	6510	G	T	MI.3165	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	607	203	A	S	Gct/Tct	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-3.49	deleterious	-2.59	high_impact	3.65	0.64	neutral	0.08	damaging	3.67	23.30	deleterious	0.31	0.55	0.41	neutral	0.69	disease	0.48	neutral	0.46	neutral	1	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.27	high_impact	0.57	0.9	4.68	6.73	0.31	N	0.64	disease_causing	0.86	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6511	6511	C	G	MI.3166	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	608	203	A	G	gCt/gGt	9.15	1	0	probably_damaging	0.99	deleterious	0	neutral	2.57	deleterious	-3.35	deleterious	-3.47	high_impact	3.68	0.64	neutral	0.07	damaging	3.90	23.50	deleterious	0.24	0.55	0.43	neutral	0.64	disease	0.49	neutral	0.44	neutral	1	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-1.48	low_impact	2.3	high_impact	0.71	0.9	4.68	6.73	0.48	N	0.56	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6511	6511	C	A	MI.3167	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	608	203	A	D	gCt/gAt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.82	deleterious	-5.2	high_impact	5.25	0.55	damaging	0.05	damaging	4.47	24.20	deleterious	0.13	0.55	0.67	disease	0.87	disease	0.7	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.49	0.9	4.68	6.73	0.69	P	0.89	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6511	6511	C	T	MI.3168	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	608	203	A	V	gCt/gTt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-2.05	deleterious	-3.47	high_impact	5.25	0.61	neutral	0.06	damaging	4.29	24.00	deleterious	0.36	0.55	0.45	neutral	0.73	disease	0.59	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.59	0.9	4.68	6.73	0.72	P	0.75	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6513	6513	G	T	MI.3169	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	610	204	A	S	Gct/Tct	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-1.69	neutral	-0.22	neutral_impact	0.51	0.51	damaging	0.08	damaging	3.71	23.30	deleterious	0.39	0.55	0.58	disease	0.58	disease	0.41	neutral	0.5	neutral	0	1	deleterious	0	neutral	2	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	-0.63	medium_impact	0.61	0.9	1.95	6.7	0.34	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8674	8674	A	T	MI.317	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	148	50	I	F	Atc/Ttc	-2.88	0	0	possibly_damaging	0.47	neutral	0.33	neutral	4.32	neutral	-0.81	deleterious	-3.07	neutral_impact	0.78	0.88	neutral	0.77	neutral	0.94	10.29	neutral	0.52	0.65	0.71	disease	0.43	neutral	0.26	neutral	0.64	disease	3	0.64	neutral	0.43	neutral	-3	neutral	0.53	deleterious	-0.71	medium_impact	0.12	medium_impact	-0.43	medium_impact	0.70	0.9	17.7	19.1	0.37	N	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6513	6513	G	A	MI.3170	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	610	204	A	T	Gct/Act	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-1.22	neutral	-1.87	low_impact	1.71	0.49	damaging	0.07	damaging	4.21	23.90	deleterious	0.4	0.55	0.56	disease	0.43	neutral	0.51	disease	0.62	disease	2	1	deleterious	0	neutral	2	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	0.48	medium_impact	0.55	0.9	1.95	6.7	0.35	N	0.20	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6513	6513	G	C	MI.3171	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	610	204	A	P	Gct/Cct	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-3.74	neutral	-1.97	medium_impact	2.4	0.49	damaging	0.06	damaging	3.86	23.50	deleterious	0.19	0.55	0.79	disease	0.88	disease	0.64	disease	0.81	disease	6	1	deleterious	0	neutral	5	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	1.12	medium_impact	0.62	0.9	1.95	6.7	0.26	N	0.85	polymorphism	0.97	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6514	6514	C	G	MI.3172	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	611	204	A	G	gCt/gGt	5.22	1	0	probably_damaging	0.99	neutral	1	neutral	2.7	neutral	-1.06	neutral	4.43	neutral_impact	-2.79	0.54	damaging	0.13	damaging	1.27	12.09	neutral	0.25	0.55	0.28	neutral	0.08	neutral	0.19	neutral	0.29	neutral	4	0.99	deleterious	0.51	deleterious	-2	neutral	0.65	deleterious	-2.64	low_impact	1.86	high_impact	-3.68	low_impact	0.58	0.9	1.95	6.7	0.47	N	0.56	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6514	6514	C	A	MI.3173	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	611	204	A	D	gCt/gAt	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-4.03	neutral	-1.24	medium_impact	2.06	0.51	damaging	0.05	damaging	4.46	24.20	deleterious	0.17	0.55	0.82	disease	0.86	disease	0.64	disease	0.8	disease	6	1	deleterious	0	deleterious	5	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	0.8	medium_impact	0.51	0.9	1.95	6.7	0.44	N	0.89	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6514	6514	C	T	MI.3174	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	611	204	A	V	gCt/gTt	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.87	neutral	0.42	deleterious	-2.67	low_impact	1.43	0.5	damaging	0.06	damaging	4.47	24.20	deleterious	0.34	0.55	0.18	neutral	0.66	disease	0.53	disease	0.61	disease	2	1	deleterious	0	deleterious	2	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	0.22	medium_impact	0.46	0.9	1.95	6.7	0.48	P	0.75	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6516	6516	G	C	MI.3175	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	613	205	G	R	Ggc/Cgc	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.88	neutral	-1.76	neutral	-1.49	medium_impact	2.46	0.47	damaging	0.01	damaging	4.00	23.60	deleterious	0.17	0.55	0.57	disease	0.9	disease	0.63	disease	0.78	disease	6	1	deleterious	0	deleterious	5	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	1.17	medium_impact	0.80	0.9	2.14	8.1	0.27	N	0.95	polymorphism	0.97	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6516	6516	G	T	MI.3176	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	613	205	G	C	Ggc/Tgc	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.86	deleterious	-4.44	neutral	-0.81	medium_impact	2.62	0.51	damaging	0.01	damaging	4.18	23.80	deleterious	0.11	0.55	0.82	disease	0.84	disease	0.43	neutral	0.76	disease	5	1	deleterious	0	deleterious	5	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	1.32	medium_impact	0.66	0.9	2.14	8.1	0.28	N	0.98	polymorphism	0.95	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6516	6516	G	A	MI.3177	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	613	205	G	S	Ggc/Agc	-7.51	0	0	benign	0.42	neutral	0.07	neutral	2.91	neutral	-0.73	neutral	0.25	medium_impact	1.97	0.46	damaging	0.02	damaging	4.21	23.90	deleterious	0.32	0.55	0.22	neutral	0.68	disease	0.41	neutral	0.5	disease	0	0.92	neutral	0.33	neutral	-3	neutral	0.27	neutral	-0.62	medium_impact	-0.43	medium_impact	0.72	medium_impact	0.69	0.9	2.14	8.1	0.37	N	0.73	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6517	6517	G	A	MI.3178	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	614	205	G	D	gGc/gAc	9.15	1	0	probably_damaging	0.99	deleterious	0	neutral	2.87	neutral	-1.78	neutral	-2.17	medium_impact	3.16	0.47	damaging	0.01	damaging	3.84	23.40	deleterious	0.13	0.55	0.55	disease	0.87	disease	0.66	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	1.82	medium_impact	0.42	0.9	2.14	8.1	0.52	P	0.97	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6517	6517	G	C	MI.3179	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	614	205	G	A	gGc/gCc	9.15	1	0	possibly_damaging	0.6	neutral	1	neutral	3.21	neutral	1.15	neutral	2.58	neutral_impact	-1.99	0.51	damaging	0.17	damaging	0.39	6.53	deleterious	0.31	0.55	0.18	neutral	0.12	neutral	0.13	neutral	0.27	neutral	5	0.6	neutral	0.7	deleterious	-3	neutral	0.52	deleterious	-0.92	medium_impact	1.86	high_impact	-2.94	low_impact	0.57	0.9	2.14	8.1	0.53	P	0.64	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8675	8675	T	G	MI.318	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	149	50	I	S	aTc/aGc	-0.57	0	0	benign	0.11	neutral	0.14	neutral	4.26	neutral	-1.89	deleterious	-4.39	medium_impact	1.94	0.83	neutral	0.65	neutral	2.26	17.90	deleterious	0.29	0.65	0.65	disease	0.6	disease	0.32	neutral	0.5	disease	0	0.84	neutral	0.52	deleterious	-3	neutral	0.31	neutral	0.11	medium_impact	-0.15	medium_impact	0.57	medium_impact	0.50	0.9	17.7	19.1	0.38	N	0.65	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6517	6517	G	T	MI.3180	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	614	205	G	V	gGc/gTc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.96	neutral	-1.72	neutral	-0.8	medium_impact	2.19	0.48	damaging	0.01	damaging	3.80	23.40	deleterious	0.16	0.55	0.61	disease	0.79	disease	0.56	disease	0.72	disease	4	1	deleterious	0	deleterious	5	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	0.92	medium_impact	0.51	0.9	2.14	8.1	0.47	N	0.93	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6519	6519	A	G	MI.3181	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	616	206	I	V	Atc/Gtc	-14.22	0	0	probably_damaging	0.95	deleterious	0.01	neutral	2.91	neutral	0.01	neutral	-0.86	high_impact	3.65	0.58	damaging	0.17	damaging	3.11	22.50	deleterious	0.64	0.7	0.22	neutral	0.46	neutral	0.48	neutral	0.4	neutral	2	1	deleterious	0.03	neutral	6	deleterious	0.60	deleterious	-1.96	low_impact	-0.92	medium_impact	2.27	high_impact	0.63	0.9	3.31	6.64	0.4	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6519	6519	A	T	MI.3182	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	616	206	I	F	Atc/Ttc	-14.22	0	0	probably_damaging	1	deleterious	0.04	neutral	2.84	neutral	-1.66	deleterious	-3.42	high_impact	4.34	0.56	damaging	0.08	damaging	3.84	23.40	deleterious	0.34	0.55	0.56	disease	0.79	disease	0.63	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-0.58	medium_impact	2.91	high_impact	0.84	0.9	3.31	6.64	0.32	N	0.85	polymorphism	0.71	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6519	6519	A	C	MI.3183	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	616	206	I	L	Atc/Ctc	-14.22	0	0	probably_damaging	0.98	neutral	0.1	neutral	3.03	neutral	0.55	neutral	-1.65	medium_impact	2.62	0.61	neutral	0.1	damaging	3.83	23.40	deleterious	0.49	0.55	0.18	neutral	0.62	disease	0.26	neutral	0.4	neutral	2	0.99	deleterious	0.06	neutral	1	deleterious	0.47	deleterious	-2.35	low_impact	-0.34	medium_impact	1.32	medium_impact	0.82	0.9	3.31	6.64	0.34	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6520	6520	T	A	MI.3184	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	617	206	I	N	aTc/aAc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.77	deleterious	-3.37	deleterious	-6.02	high_impact	4.8	0.56	damaging	0.09	damaging	4.48	24.20	deleterious	0.23	0.55	0.69	disease	0.85	disease	0.63	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.33	high_impact	0.77	0.9	3.31	6.64	0.66	P	0.94	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6520	6520	T	G	MI.3185	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	617	206	I	S	aTc/aGc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-2	deleterious	-5.15	high_impact	5.14	0.6	damaging	0.2	damaging	4.34	24.00	deleterious	0.27	0.55	0.54	disease	0.86	disease	0.63	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.70	0.9	3.31	6.64	0.7	P	0.62	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6520	6520	T	C	MI.3186	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	617	206	I	T	aTc/aCc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-1.66	deleterious	-4.28	high_impact	4.8	0.6	damaging	0.09	damaging	3.47	23.00	deleterious	0.46	0.55	0.49	neutral	0.73	disease	0.61	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.33	high_impact	0.65	0.9	3.31	6.64	0.67	P	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6521	6521	C	A	MI.3187	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	618	206	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-1.98	deleterious	-2.54	high_impact	4.25	0.63	neutral	0.08	damaging	3.79	23.40	deleterious	0.43	0.55	0.56	disease	0.72	disease	0.47	neutral	0.51	disease	0	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.84	0.9	3.31	6.64	0.44	N	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6521	6521	C	G	MI.3188	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	618	206	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-1.98	deleterious	-2.54	high_impact	4.25	0.63	neutral	0.08	damaging	3.35	22.90	deleterious	0.43	0.55	0.56	disease	0.72	disease	0.47	neutral	0.51	disease	0	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.84	0.9	3.31	6.64	0.44	N	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6522	6522	A	C	MI.3189	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	619	207	T	P	Act/Cct	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-3.75	deleterious	-5.19	high_impact	5.22	0.55	damaging	0.13	damaging	3.49	23.10	deleterious	0.2	0.55	0.7	disease	0.85	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.58	0.9	2.14	6.69	0.68	P	0.92	disease_causing	0.93	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8675	8675	T	A	MI.319	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	149	50	I	N	aTc/aAc	-0.57	0	0	benign	0.25	neutral	0.1	neutral	4.26	neutral	-1.86	deleterious	-5.06	medium_impact	2	0.81	neutral	0.42	neutral	2.66	20.50	deleterious	0.34	0.65	0.84	disease	0.69	disease	0.42	neutral	0.58	disease	2	0.88	neutral	0.43	neutral	-3	neutral	0.55	deleterious	-0.3	medium_impact	-0.25	medium_impact	0.62	medium_impact	0.41	0.9	17.7	19.1	0.31	N	0.76	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6522	6522	A	T	MI.3190	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	619	207	T	S	Act/Tct	-2.42	0	0	probably_damaging	0.98	deleterious	0	neutral	2.65	neutral	-2.13	deleterious	-3.45	high_impact	4.67	0.7	neutral	0.14	damaging	3.33	22.90	deleterious	0.49	0.55	0.48	neutral	0.76	disease	0.65	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.35	low_impact	-1.48	low_impact	3.21	high_impact	0.66	0.9	2.14	6.69	0.53	N	0.79	polymorphism	0.54	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6522	6522	A	G	MI.3191	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	619	207	T	A	Act/Gct	-2.42	0	0	probably_damaging	0.98	deleterious	0	neutral	2.73	neutral	-0.5	deleterious	-4.32	high_impact	4.53	0.75	neutral	0.13	damaging	3.52	23.10	deleterious	0.59	0.65	0.27	neutral	0.68	disease	0.66	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.69	deleterious	-2.35	low_impact	-1.48	low_impact	3.08	high_impact	0.44	0.9	2.14	6.69	0.45	N	0.69	disease_causing	0.71	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6523	6523	C	G	MI.3192	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	620	207	T	S	aCt/aGt	8.69	1	0	probably_damaging	0.98	deleterious	0	neutral	2.65	neutral	-2.13	deleterious	-3.45	high_impact	4.67	0.7	neutral	0.14	damaging	3.52	23.10	deleterious	0.49	0.55	0.48	neutral	0.76	disease	0.65	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.35	low_impact	-1.48	low_impact	3.21	high_impact	0.66	0.9	2.14	6.69	0.59	P	0.79	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6523	6523	C	A	MI.3193	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	620	207	T	N	aCt/aAt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-3.32	deleterious	-4.33	high_impact	5.22	0.57	damaging	0.09	damaging	3.61	23.20	deleterious	0.47	0.55	0.66	disease	0.83	disease	0.67	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.73	0.9	2.14	6.69	0.7	P	0.80	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6523	6523	C	T	MI.3194	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	620	207	T	I	aCt/aTt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-0.47	deleterious	-5.18	high_impact	3.75	0.57	damaging	0.13	damaging	3.90	23.50	deleterious	0.32	0.55	0.26	neutral	0.87	disease	0.56	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.36	high_impact	0.61	0.9	2.14	6.69	0.44	N	0.92	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6525	6525	A	T	MI.3195	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	622	208	M	L	Ata/Tta	-10.51	0	0	possibly_damaging	0.9	deleterious	0	neutral	2.86	neutral	-0.85	deleterious	-2.58	high_impact	3.61	0.69	neutral	0.1	damaging	3.58	23.20	deleterious	0.41	0.55	0.2	neutral	0.8	disease	0.57	disease	0.58	disease	2	1	deleterious	0.05	neutral	5	deleterious	0.60	deleterious	-1.65	low_impact	-1.48	low_impact	2.23	high_impact	0.63	0.9	4.29	6.71	0.32	N	0.61	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6525	6525	A	G	MI.3196	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	622	208	M	V	Ata/Gta	-10.51	0	0	probably_damaging	0.94	deleterious	0	neutral	2.75	neutral	-1.97	deleterious	-3.44	high_impact	4.26	0.65	neutral	0.12	damaging	2.88	21.80	deleterious	0.42	0.55	0.54	disease	0.79	disease	0.71	disease	0.69	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.76	deleterious	-1.88	low_impact	-1.48	low_impact	2.83	high_impact	0.58	0.9	4.29	6.71	0.35	N	0.88	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6525	6525	A	C	MI.3197	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	622	208	M	L	Ata/Cta	-10.51	0	0	possibly_damaging	0.9	deleterious	0	neutral	2.86	neutral	-0.85	deleterious	-2.58	high_impact	3.61	0.69	neutral	0.1	damaging	3.39	23.00	deleterious	0.41	0.55	0.2	neutral	0.8	disease	0.57	disease	0.58	disease	2	1	deleterious	0.05	neutral	5	deleterious	0.60	deleterious	-1.65	low_impact	-1.48	low_impact	2.23	high_impact	0.63	0.9	4.29	6.71	0.31	N	0.61	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6526	6526	T	C	MI.3198	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	623	208	M	T	aTa/aCa	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.62	deleterious	-5.15	high_impact	5.24	0.6	damaging	0.17	damaging	2.97	22.10	deleterious	0.28	0.55	0.77	disease	0.85	disease	0.65	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.35	0.9	4.29	6.71	0.69	P	0.79	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6526	6526	T	A	MI.3199	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	623	208	M	K	aTa/aAa	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-3.37	deleterious	-5.16	high_impact	5.24	0.65	neutral	0.1	damaging	3.95	23.60	deleterious	0.12	0.55	0.89	disease	0.91	disease	0.78	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.46	0.9	4.29	6.71	0.76	P	0.93	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8540	8540	T	C	MI.32	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	14	5	L	P	cTg/cCg	-1.95	0	0	probably_damaging	0.99	deleterious	0	neutral	4.1	deleterious	-4.67	deleterious	-5.58	medium_impact	2.93	0.72	neutral	0.32	neutral	3.72	23.30	deleterious	0.23	0.65	0.89	disease	0.73	disease	0.78	disease	0.84	disease	7	1	deleterious	0.01	neutral	5	deleterious	0.88	deleterious	-2.65	low_impact	-1.4	low_impact	1.41	medium_impact	0.55	0.9	50.44	8.42	0.28	N	1.00	disease_causing	1	0.35	rs878852987	Uncertain_significance	not_provided	236915	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8675	8675	T	C	MI.320	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	149	50	I	T	aTc/aCc	-0.57	0	0	benign	0.01	neutral	0.18	neutral	4.35	neutral	-0.44	deleterious	-3.14	low_impact	1.33	0.88	neutral	0.96	neutral	0.15	4.10	deleterious	0.44	0.65	0.56	disease	0.37	neutral	0.28	neutral	0.61	disease	2	0.82	neutral	0.59	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	-0.08	medium_impact	0.04	medium_impact	0.48	0.9	17.7	19.1	0.4	N	0.18	polymorphism	1	0.07	.	.	.	.	.	.	COSM6716151	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6527	6527	A	C	MI.3200	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	624	208	M	I	atA/atC	7.53	1	0	probably_damaging	0.96	deleterious	0	neutral	2.72	neutral	-2.45	deleterious	-3.44	high_impact	4.34	0.59	damaging	0.13	damaging	3.45	23.00	deleterious	0.38	0.55	0.48	neutral	0.81	disease	0.7	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.06	low_impact	-1.48	low_impact	2.91	high_impact	0.71	0.9	4.29	6.71	0.57	P	0.87	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6527	6527	A	T	MI.3201	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	624	208	M	I	atA/atT	7.53	1	0	probably_damaging	0.96	deleterious	0	neutral	2.72	neutral	-2.45	deleterious	-3.44	high_impact	4.34	0.59	damaging	0.13	damaging	3.50	23.10	deleterious	0.38	0.55	0.48	neutral	0.81	disease	0.7	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.06	low_impact	-1.48	low_impact	2.91	high_impact	0.71	0.9	4.29	6.71	0.54	P	0.87	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6528	6528	C	G	MI.3202	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	625	209	L	V	Cta/Gta	-1.03	0	0	probably_damaging	0.99	deleterious	0	neutral	2.47	neutral	-2.16	deleterious	-2.6	high_impact	3.8	0.51	damaging	0.04	damaging	3.43	23.00	deleterious	0.34	0.55	0.54	disease	0.63	disease	0.39	neutral	0.46	neutral	1	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	2.41	high_impact	0.75	0.9	2.34	7.33	0.32	N	0.66	disease_causing	0.56	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6528	6528	C	A	MI.3203	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	625	209	L	M	Cta/Ata	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	2.36	deleterious	-3.12	neutral	-1.73	high_impact	4.38	0.56	damaging	0.07	damaging	3.74	23.30	deleterious	0.26	0.55	0.26	neutral	0.69	disease	0.35	neutral	0.5	neutral	0	1	deleterious	0	neutral	6	deleterious	0.72	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.70	0.9	2.34	7.33	0.35	N	0.59	disease_causing	0.51	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6529	6529	T	A	MI.3204	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	626	209	L	Q	cTa/cAa	1.05	0.4	0	probably_damaging	1	deleterious	0	neutral	2.33	deleterious	-3.91	deleterious	-5.2	high_impact	5.27	0.55	damaging	0.03	damaging	4.24	23.90	deleterious	0.15	0.55	0.56	disease	0.87	disease	0.54	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.62	0.9	2.34	7.33	0.57	P	0.82	disease_causing	0.88	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6529	6529	T	G	MI.3205	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	626	209	L	R	cTa/cGa	1.05	0.4	0	probably_damaging	1	deleterious	0	neutral	2.34	deleterious	-4.81	deleterious	-5.2	high_impact	5.27	0.52	damaging	0.03	damaging	4.17	23.80	deleterious	0.14	0.55	0.79	disease	0.9	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.52	0.9	2.34	7.33	0.61	P	0.90	disease_causing	0.9	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6529	6529	T	C	MI.3206	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	626	209	L	P	cTa/cCa	1.05	0.4	0	probably_damaging	1	deleterious	0	neutral	2.33	deleterious	-5.43	deleterious	-6.07	high_impact	5.27	0.41	damaging	0.03	damaging	3.96	23.60	deleterious	0.16	0.55	0.87	disease	0.84	disease	0.69	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.59	0.9	2.34	7.33	0.6	P	0.83	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6531	6531	C	G	MI.3207	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	628	210	L	V	Cta/Gta	-2.88	0	0	probably_damaging	0.99	deleterious	0	neutral	2.6	neutral	-1.71	deleterious	-2.59	high_impact	4.67	0.48	damaging	0.04	damaging	3.43	23.00	deleterious	0.41	0.55	0.39	neutral	0.7	disease	0.57	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	3.21	high_impact	0.62	0.9	2.92	6.75	0.46	N	0.66	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6531	6531	C	A	MI.3208	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	628	210	L	M	Cta/Ata	-2.88	0	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-2.89	neutral	-1.73	high_impact	4.88	0.52	damaging	0.06	damaging	3.76	23.30	deleterious	0.32	0.55	0.52	disease	0.73	disease	0.56	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	3.41	high_impact	0.65	0.9	2.92	6.75	0.58	P	0.59	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6532	6532	T	G	MI.3209	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	629	210	L	R	cTa/cGa	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.44	deleterious	-5.19	high_impact	5.22	0.48	damaging	0.03	damaging	4.17	23.80	deleterious	0.17	0.55	0.72	disease	0.92	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.67	0.9	2.92	6.75	0.58	P	0.90	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8676	8676	C	A	MI.321	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	150	50	I	M	atC/atA	1.98	0.02	0	possibly_damaging	0.66	neutral	0.16	neutral	4.28	neutral	-1.48	neutral	-1.92	low_impact	1.16	0.88	neutral	0.68	neutral	2.26	17.89	deleterious	0.56	0.65	0.71	disease	0.31	neutral	0.2	neutral	0.63	disease	3	0.86	neutral	0.25	neutral	-3	neutral	0.59	deleterious	-1.03	low_impact	-0.12	medium_impact	-0.1	medium_impact	0.75	0.9	17.7	19.1	0.45	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6532	6532	T	A	MI.3210	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	629	210	L	Q	cTa/cAa	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.59	deleterious	-5.19	high_impact	5.22	0.51	damaging	0.04	damaging	4.18	23.80	deleterious	0.19	0.55	0.74	disease	0.89	disease	0.58	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.68	0.9	2.92	6.75	0.59	P	0.82	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6532	6532	T	C	MI.3211	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	629	210	L	P	cTa/cCa	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-5.04	deleterious	-6.06	high_impact	5.22	0.34	damaging	0.05	damaging	3.95	23.60	deleterious	0.16	0.55	0.79	disease	0.87	disease	0.71	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.56	0.9	2.92	6.75	0.57	P	0.83	disease_causing	0.86	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6534	6534	A	T	MI.3212	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	631	211	T	S	Aca/Tca	-5.19	0	0	probably_damaging	0.99	deleterious	0	neutral	2.78	neutral	-1.6	deleterious	-3.33	medium_impact	3.18	0.62	neutral	0.15	damaging	3.27	22.80	deleterious	0.43	0.55	0.3	neutral	0.75	disease	0.28	neutral	0.37	neutral	3	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-2.64	low_impact	-1.48	low_impact	1.84	medium_impact	0.72	0.9	2.14	7.99	0.35	N	0.79	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6534	6534	A	G	MI.3213	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	631	211	T	A	Aca/Gca	-5.19	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.82	neutral	-0.53	deleterious	-4.19	medium_impact	2.58	0.78	neutral	0.12	damaging	3.50	23.10	deleterious	0.47	0.55	0.23	neutral	0.7	disease	0.46	neutral	0.45	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.69	deleterious	-2.64	low_impact	-0.92	medium_impact	1.28	medium_impact	0.54	0.9	2.14	7.99	0.27	N	0.69	polymorphism	0.95	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6534	6534	A	C	MI.3214	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	631	211	T	P	Aca/Cca	-5.19	0	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.61	deleterious	-5.09	high_impact	4.92	0.58	damaging	0.11	damaging	3.51	23.10	deleterious	0.19	0.55	0.66	disease	0.89	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.61	0.9	2.14	7.99	0.65	P	0.92	polymorphism	0.8	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6535	6535	C	T	MI.3215	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	632	211	T	M	aCa/aTa	6.84	1	0	probably_damaging	1	neutral	0.11	neutral	2.77	neutral	-0.87	deleterious	-5.01	medium_impact	3.15	0.73	neutral	0.11	damaging	4.01	23.60	deleterious	0.27	0.55	0.5	neutral	0.85	disease	0.28	neutral	0.39	neutral	2	1	deleterious	0.06	neutral	1	deleterious	0.73	deleterious	-3.58	low_impact	-0.31	medium_impact	1.81	medium_impact	0.70	0.9	2.14	7.99	0.48	N	0.96	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6535	6535	C	A	MI.3216	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	632	211	T	K	aCa/aAa	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.77	deleterious	-5.06	high_impact	4.92	0.62	neutral	0.09	damaging	4.51	24.30	deleterious	0.21	0.55	0.5	neutral	0.93	disease	0.69	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.60	0.9	2.14	7.99	0.68	P	0.88	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6537	6537	G	T	MI.3217	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	634	212	D	Y	Gac/Tac	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.38	deleterious	-5.8	deleterious	-7.81	high_impact	5.3	0.5	damaging	0.07	damaging	3.87	23.50	deleterious	0.22	0.55	0.87	disease	0.95	disease	0.79	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.41	0.9	3.12	6.68	0.53	P	0.94	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6537	6537	G	C	MI.3218	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	634	212	D	H	Gac/Cac	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.04	deleterious	-6.07	high_impact	4.96	0.54	damaging	0.07	damaging	3.63	23.20	deleterious	0.32	0.55	0.8	disease	0.91	disease	0.84	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.44	0.9	3.12	6.68	0.65	P	0.97	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6537	6537	G	A	MI.3219	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	634	212	D	N	Gac/Aac	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-2.43	deleterious	-4.34	high_impact	4.96	0.38	damaging	0.09	damaging	4.19	23.80	deleterious	0.63	0.65	0.62	disease	0.89	disease	0.76	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.81	0.9	3.12	6.68	0.69	P	0.89	disease_causing	0.99	0.48	.	.	.	.	.	.	COSM5653112	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8676	8676	C	G	MI.322	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	150	50	I	M	atC/atG	1.98	0.02	0	possibly_damaging	0.66	neutral	0.16	neutral	4.28	neutral	-1.48	neutral	-1.92	low_impact	1.16	0.88	neutral	0.68	neutral	1.80	14.98	neutral	0.56	0.65	0.71	disease	0.31	neutral	0.2	neutral	0.63	disease	3	0.86	neutral	0.25	neutral	-3	neutral	0.59	deleterious	-1.03	low_impact	-0.12	medium_impact	-0.1	medium_impact	0.75	0.9	17.7	19.1	0.45	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6538	6538	A	C	MI.3220	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	635	212	D	A	gAc/gCc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-3.8	deleterious	-6.94	high_impact	5.3	0.62	neutral	0.1	damaging	3.60	23.20	deleterious	0.28	0.55	0.64	disease	0.87	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.49	0.9	3.12	6.68	0.73	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6538	6538	A	T	MI.3221	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	635	212	D	V	gAc/gTc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.4	deleterious	-4.96	deleterious	-7.81	high_impact	4.96	0.48	damaging	0.08	damaging	3.71	23.30	deleterious	0.23	0.55	0.79	disease	0.93	disease	0.76	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.36	0.9	3.12	6.68	0.59	P	0.93	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6538	6538	A	G	MI.3222	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	635	212	D	G	gAc/gGc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.46	deleterious	-6.07	high_impact	5.3	0.49	damaging	0.1	damaging	3.95	23.60	deleterious	0.35	0.55	0.73	disease	0.92	disease	0.77	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.39	0.9	3.12	6.68	0.7	P	0.85	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6539	6539	C	G	MI.3223	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	636	212	D	E	gaC/gaG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-2.35	deleterious	-3.47	high_impact	4.41	0.46	damaging	0.09	damaging	3.91	23.50	deleterious	0.54	0.6	0.33	neutral	0.87	disease	0.75	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.61	0.9	3.12	6.68	0.59	P	0.65	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6539	6539	C	A	MI.3224	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	636	212	D	E	gaC/gaA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-2.35	deleterious	-3.47	high_impact	4.41	0.46	damaging	0.09	damaging	4.21	23.90	deleterious	0.54	0.6	0.33	neutral	0.87	disease	0.75	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.61	0.9	3.12	6.68	0.61	P	0.65	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6540	6540	C	T	MI.3225	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	637	213	R	C	Cgc/Tgc	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-5.09	deleterious	-6.94	high_impact	5.29	0.49	damaging	0.1	damaging	4.98	25.10	deleterious	0.26	0.55	0.91	disease	0.85	disease	0.73	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.82	0.9	2.14	6.91	0.54	P	1.00	disease_causing	0.98	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6540	6540	C	A	MI.3226	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	637	213	R	S	Cgc/Agc	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.25	deleterious	-5.2	high_impact	4.59	0.58	damaging	0.21	damaging	4.70	24.60	deleterious	0.24	0.55	0.61	disease	0.81	disease	0.66	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.14	high_impact	0.47	0.9	2.14	6.91	0.42	N	0.80	polymorphism	0.84	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6540	6540	C	G	MI.3227	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	637	213	R	G	Cgc/Ggc	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-3.86	deleterious	-6.07	high_impact	5.29	0.5	damaging	0.25	damaging	4.19	23.80	deleterious	0.24	0.55	0.75	disease	0.76	disease	0.73	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.37	0.9	2.14	6.91	0.61	P	0.92	polymorphism	0.85	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6541	6541	G	C	MI.3228	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	638	213	R	P	cGc/cCc	3.6	0.99	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.36	deleterious	-6.08	high_impact	4.59	0.42	damaging	0.15	damaging	4.27	24.00	deleterious	0.17	0.55	0.8	disease	0.84	disease	0.71	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.14	high_impact	0.38	0.9	2.14	6.91	0.64	P	0.99	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6541	6541	G	A	MI.3229	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	638	213	R	H	cGc/cAc	3.6	0.99	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-4.2	deleterious	-4.34	high_impact	4.94	0.51	damaging	0.08	damaging	4.41	24.10	deleterious	0.41	0.55	0.76	disease	0.8	disease	0.68	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.46	high_impact	0.86	0.9	2.14	6.91	0.68	P	0.98	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8677	8677	A	G	MI.323	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	151	51	K	E	Aaa/Gaa	-8.89	0	0	benign	0.01	neutral	0.73	neutral	4.46	neutral	0.57	neutral	-0.83	neutral_impact	0.34	0.88	neutral	0.52	neutral	0.69	8.77	deleterious	0.47	0.65	0.29	neutral	0.64	disease	0.38	neutral	0.53	disease	1	0.25	neutral	0.86	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	0.54	medium_impact	-0.81	medium_impact	0.73	0.9	20.8	18.4	0.26	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6541	6541	G	T	MI.3230	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	638	213	R	L	cGc/cTc	3.6	0.99	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-1.89	deleterious	-6.07	high_impact	3.67	0.52	damaging	0.22	damaging	4.34	24.00	deleterious	0.28	0.55	0.38	neutral	0.89	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.29	high_impact	0.37	0.9	2.14	6.91	0.5	P	0.99	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6543	6543	A	G	MI.3231	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	640	214	N	D	Aac/Gac	-7.74	0	0	probably_damaging	0.99	deleterious	0	neutral	2.75	deleterious	-3.59	deleterious	-4.33	high_impact	4.64	0.49	damaging	0.19	damaging	3.92	23.50	deleterious	0.58	0.65	0.41	neutral	0.76	disease	0.55	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	3.19	high_impact	0.52	0.9	2.53	7.24	0.48	N	0.92	polymorphism	0.99	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6543	6543	A	C	MI.3232	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	640	214	N	H	Aac/Cac	-7.74	0	0	probably_damaging	1	neutral	0.06	neutral	2.81	neutral	-1.82	deleterious	-4.33	medium_impact	3.13	0.62	neutral	0.11	damaging	3.17	22.70	deleterious	0.44	0.55	0.36	neutral	0.82	disease	0.56	disease	0.58	disease	2	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.58	low_impact	-0.47	medium_impact	1.79	medium_impact	0.49	0.9	2.53	7.24	0.29	N	0.83	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6543	6543	A	T	MI.3233	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	640	214	N	Y	Aac/Tac	-7.74	0	0	probably_damaging	1	deleterious	0	neutral	2.81	neutral	-1.77	deleterious	-6.93	high_impact	4.64	0.62	neutral	0.12	damaging	3.77	23.40	deleterious	0.28	0.55	0.52	disease	0.87	disease	0.58	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.19	high_impact	0.36	0.9	2.53	7.24	0.45	N	0.93	polymorphism	0.95	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6544	6544	A	T	MI.3234	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	641	214	N	I	aAc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-1.64	deleterious	-7.8	high_impact	4.22	0.62	neutral	0.12	damaging	4.47	24.20	deleterious	0.29	0.55	0.58	disease	0.9	disease	0.61	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.8	high_impact	0.33	0.9	2.53	7.24	0.49	N	0.98	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6544	6544	A	G	MI.3235	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	641	214	N	S	aAc/aGc	8.69	1	0	probably_damaging	0.98	deleterious	0	neutral	2.84	neutral	-1.28	deleterious	-4.33	high_impact	4.04	0.66	neutral	0.14	damaging	3.61	23.20	deleterious	0.58	0.65	0.18	neutral	0.81	disease	0.54	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.35	low_impact	-1.48	low_impact	2.63	high_impact	0.31	0.9	2.53	7.24	0.48	N	0.79	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6544	6544	A	C	MI.3236	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	641	214	N	T	aAc/aCc	8.69	1	0	probably_damaging	1	deleterious	0.03	neutral	2.79	neutral	-2.13	deleterious	-5.19	high_impact	4	0.63	neutral	0.13	damaging	3.88	23.50	deleterious	0.43	0.55	0.31	neutral	0.82	disease	0.62	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-0.65	medium_impact	2.59	high_impact	0.44	0.9	2.53	7.24	0.45	N	0.59	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6545	6545	C	A	MI.3237	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	642	214	N	K	aaC/aaA	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-2.65	deleterious	-5.2	high_impact	3.69	0.57	damaging	0.11	damaging	4.51	24.30	deleterious	0.61	0.65	0.23	neutral	0.87	disease	0.6	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.31	high_impact	0.64	0.9	2.53	7.24	0.43	N	0.92	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6545	6545	C	G	MI.3238	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	642	214	N	K	aaC/aaG	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-2.65	deleterious	-5.2	high_impact	3.69	0.57	damaging	0.11	damaging	4.03	23.70	deleterious	0.61	0.65	0.23	neutral	0.87	disease	0.6	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.31	high_impact	0.64	0.9	2.53	7.24	0.41	N	0.92	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6546	6546	C	G	MI.3239	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	643	215	L	V	Ctc/Gtc	-3.11	0	0	benign	0.09	deleterious	0.04	neutral	2.77	neutral	-1.72	neutral	-1.61	medium_impact	2.73	0.52	damaging	0.36	neutral	1.53	13.49	neutral	0.45	0.55	0.57	disease	0.55	disease	0.44	neutral	0.5	disease	0	0.96	neutral	0.48	deleterious	1	deleterious	0.28	neutral	0.19	medium_impact	-0.58	medium_impact	1.42	medium_impact	0.61	0.9	5.65	8.72	0.42	N	0.66	polymorphism	0.87	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8677	8677	A	C	MI.324	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	151	51	K	Q	Aaa/Caa	-8.89	0	0	benign	0	neutral	0.62	neutral	4.34	neutral	-0.71	neutral	0.15	neutral_impact	0.7	0.95	neutral	0.98	neutral	-0.74	0.06	neutral	0.52	0.65	0.45	neutral	0.33	neutral	0.21	neutral	0.47	neutral	1	0.38	neutral	0.81	deleterious	-6	neutral	0.15	neutral	2.09	high_impact	0.41	medium_impact	-0.5	medium_impact	0.61	0.9	20.8	18.4	0.39	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6546	6546	C	T	MI.3240	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	643	215	L	F	Ctc/Ttc	-3.11	0	0	benign	0.01	neutral	0.69	neutral	2.94	neutral	-0.84	neutral	-0.45	neutral_impact	-0.14	0.57	damaging	0.58	neutral	0.34	6.11	deleterious	0.39	0.55	0.25	neutral	0.13	neutral	0.16	neutral	0.25	neutral	5	0.28	neutral	0.84	deleterious	-6	neutral	0.16	neutral	1.12	medium_impact	0.39	medium_impact	-1.23	low_impact	0.58	0.9	5.65	8.72	0.4	N	0.87	polymorphism	0.57	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6546	6546	C	A	MI.3241	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	643	215	L	I	Ctc/Atc	-3.11	0	0	benign	0.21	neutral	0.09	neutral	2.76	neutral	-2.18	neutral	-0.81	low_impact	1.68	0.63	neutral	0.66	neutral	1.20	11.76	neutral	0.39	0.55	0.49	neutral	0.34	neutral	0.25	neutral	0.44	neutral	1	0.9	neutral	0.44	neutral	-6	neutral	0.25	neutral	-0.22	medium_impact	-0.37	medium_impact	0.45	medium_impact	0.72	0.9	5.65	8.72	0.51	N	0.54	polymorphism	0.92	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6547	6547	T	G	MI.3242	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	644	215	L	R	cTc/cGc	0.13	0	0	possibly_damaging	0.81	deleterious	0	neutral	2.7	deleterious	-4.38	deleterious	-4.18	high_impact	4.08	0.54	damaging	0.27	damaging	4.07	23.70	deleterious	0.2	0.55	0.88	disease	0.91	disease	0.72	disease	0.8	disease	6	1	deleterious	0.1	neutral	5	deleterious	0.83	deleterious	-1.35	low_impact	-1.48	low_impact	2.67	high_impact	0.55	0.9	5.65	8.72	0.34	N	0.90	polymorphism	0.85	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6547	6547	T	C	MI.3243	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	644	215	L	P	cTc/cCc	0.13	0	0	probably_damaging	0.93	deleterious	0	neutral	2.69	deleterious	-4.96	deleterious	-4.95	high_impact	4.43	0.49	damaging	0.39	neutral	3.86	23.50	deleterious	0.16	0.55	0.9	disease	0.89	disease	0.59	disease	0.79	disease	6	1	deleterious	0.04	neutral	6	deleterious	0.90	deleterious	-1.81	low_impact	-1.48	low_impact	2.99	high_impact	0.52	0.9	5.65	8.72	0.44	N	0.83	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6547	6547	T	A	MI.3244	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	644	215	L	H	cTc/cAc	0.13	0	0	possibly_damaging	0.86	deleterious	0	neutral	2.69	deleterious	-4.92	deleterious	-4.12	high_impact	4.08	0.57	damaging	0.28	damaging	4.04	23.70	deleterious	0.2	0.55	0.91	disease	0.81	disease	0.68	disease	0.79	disease	6	1	deleterious	0.07	neutral	5	deleterious	0.82	deleterious	-1.5	low_impact	-1.48	low_impact	2.67	high_impact	0.54	0.9	5.65	8.72	0.32	N	0.83	polymorphism	0.91	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6549	6549	A	G	MI.3245	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	646	216	N	D	Aac/Gac	-7.04	0	0	probably_damaging	0.99	deleterious	0	neutral	2.78	neutral	-1.67	deleterious	-4.32	high_impact	4.29	0.56	damaging	0.15	damaging	3.85	23.40	deleterious	0.73	0.75	0.29	neutral	0.74	disease	0.61	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.71	deleterious	-2.64	low_impact	-1.48	low_impact	2.86	high_impact	0.59	0.9	2.73	6.98	0.35	N	0.92	polymorphism	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6549	6549	A	T	MI.3246	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	646	216	N	Y	Aac/Tac	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.89	deleterious	-6.91	high_impact	5.19	0.59	damaging	0.13	damaging	3.74	23.30	deleterious	0.36	0.55	0.71	disease	0.85	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.43	0.9	2.73	6.98	0.62	P	0.93	polymorphism	0.95	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6549	6549	A	C	MI.3247	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	646	216	N	H	Aac/Cac	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.02	deleterious	-4.32	high_impact	4.5	0.48	damaging	0.15	damaging	3.11	22.50	deleterious	0.54	0.6	0.48	neutral	0.81	disease	0.72	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.48	0.9	2.73	6.98	0.47	N	0.83	polymorphism	0.99	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6550	6550	A	G	MI.3248	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	647	216	N	S	aAc/aGc	8.69	1	0	probably_damaging	0.98	neutral	0.06	neutral	2.77	neutral	-1.77	deleterious	-4.31	high_impact	3.77	0.63	neutral	0.15	damaging	3.11	22.50	deleterious	0.73	0.75	0.38	neutral	0.77	disease	0.6	disease	0.62	disease	2	1	deleterious	0.04	neutral	2	deleterious	0.74	deleterious	-2.35	low_impact	-0.47	medium_impact	2.38	high_impact	0.34	0.9	2.73	6.98	0.53	P	0.79	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6550	6550	A	C	MI.3249	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	647	216	N	T	aAc/aCc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.5	deleterious	-5.18	high_impact	4.84	0.58	damaging	0.15	damaging	3.39	23.00	deleterious	0.47	0.55	0.44	neutral	0.8	disease	0.68	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.34	0.9	2.73	6.98	0.68	P	0.59	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8678	8678	A	C	MI.325	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	152	51	K	T	aAa/aCa	-2.19	0	0	benign	0.02	neutral	0.49	neutral	4.31	neutral	-1.2	neutral	-2.06	low_impact	1.23	0.91	neutral	0.79	neutral	0.34	6.07	deleterious	0.32	0.65	0.48	neutral	0.37	neutral	0.35	neutral	0.43	neutral	1	0.48	neutral	0.74	deleterious	-6	neutral	0.18	neutral	0.85	medium_impact	0.28	medium_impact	-0.04	medium_impact	0.44	0.9	20.8	18.4	0.32	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6550	6550	A	T	MI.3250	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	647	216	N	I	aAc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-5.1	deleterious	-7.78	high_impact	5.19	0.59	damaging	0.13	damaging	4.03	23.60	deleterious	0.32	0.55	0.66	disease	0.88	disease	0.68	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.34	0.9	2.73	6.98	0.64	P	0.98	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6551	6551	C	A	MI.3251	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	648	216	N	K	aaC/aaA	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-2.38	deleterious	-5.18	high_impact	5.19	0.54	damaging	0.11	damaging	4.39	24.10	deleterious	0.66	0.7	0.33	neutral	0.86	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.61	0.9	2.73	6.98	0.65	P	0.92	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6551	6551	C	G	MI.3252	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	648	216	N	K	aaC/aaG	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-2.38	deleterious	-5.18	high_impact	5.19	0.54	damaging	0.11	damaging	3.94	23.50	deleterious	0.66	0.7	0.33	neutral	0.86	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.61	0.9	2.73	6.98	0.65	P	0.92	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6552	6552	A	T	MI.3253	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	649	217	T	S	Acc/Tcc	-5.66	0	0	probably_damaging	0.99	neutral	0.1	neutral	2.58	neutral	-2.77	deleterious	-3.39	medium_impact	2.4	0.72	neutral	0.08	damaging	3.16	22.60	deleterious	0.52	0.6	0.61	disease	0.68	disease	0.41	neutral	0.45	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.78	deleterious	-2.64	low_impact	-0.34	medium_impact	1.12	medium_impact	0.75	0.9	2.53	6.67	0.25	N	0.79	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6552	6552	A	C	MI.3254	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	649	217	T	P	Acc/Ccc	-5.66	0	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.92	deleterious	-5.17	high_impact	5.2	0.59	damaging	0.08	damaging	3.40	23.00	deleterious	0.27	0.55	0.81	disease	0.83	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.50	0.9	2.53	6.67	0.61	P	0.92	polymorphism	0.91	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6552	6552	A	G	MI.3255	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	649	217	T	A	Acc/Gcc	-5.66	0	0	probably_damaging	0.99	deleterious	0	neutral	2.62	neutral	-1.98	deleterious	-4.28	medium_impact	3.33	0.74	neutral	0.07	damaging	3.37	22.90	deleterious	0.49	0.55	0.36	neutral	0.69	disease	0.69	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-2.64	low_impact	-1.48	low_impact	1.98	medium_impact	0.56	0.9	2.53	6.67	0.29	N	0.69	polymorphism	0.98	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6553	6553	C	G	MI.3256	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	650	217	T	S	aCc/aGc	8.69	1	0	probably_damaging	0.99	neutral	0.1	neutral	2.58	neutral	-2.77	deleterious	-3.39	medium_impact	2.4	0.72	neutral	0.08	damaging	3.51	23.10	deleterious	0.52	0.6	0.61	disease	0.68	disease	0.41	neutral	0.45	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.78	deleterious	-2.64	low_impact	-0.34	medium_impact	1.12	medium_impact	0.75	0.9	2.53	6.67	0.49	N	0.79	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6553	6553	C	A	MI.3257	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	650	217	T	N	aCc/aAc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.2	deleterious	-4.29	high_impact	5.2	0.66	neutral	0.06	damaging	3.71	23.30	deleterious	0.43	0.55	0.76	disease	0.86	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.80	0.9	2.53	6.67	0.73	P	0.80	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6553	6553	C	T	MI.3258	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	650	217	T	I	aCc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-1.85	deleterious	-5.17	high_impact	4.5	0.7	neutral	0.06	damaging	4.01	23.60	deleterious	0.33	0.55	0.43	neutral	0.85	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.62	0.9	2.53	6.67	0.51	P	0.92	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6555	6555	A	T	MI.3259	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	652	218	T	S	Acc/Tcc	-15.14	0	0	benign	0	neutral	1	neutral	3.29	neutral	1.93	neutral	1.33	neutral_impact	-1.4	0.65	neutral	0.28	damaging	1.10	11.20	neutral	0.39	0.55	0.18	neutral	0.06	neutral	0.21	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	1.86	high_impact	-2.39	low_impact	0.71	0.9	4.48	10.9	0.36	N	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8678	8678	A	T	MI.326	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	152	51	K	M	aAa/aTa	-2.19	0	0	benign	0.28	neutral	0.16	neutral	4.26	deleterious	-3.14	neutral	-2.18	neutral_impact	0.5	0.86	neutral	0.74	neutral	1.01	10.73	neutral	0.35	0.65	0.55	disease	0.4	neutral	0.24	neutral	0.6	disease	2	0.81	neutral	0.44	neutral	-6	neutral	0.34	neutral	-0.37	medium_impact	-0.12	medium_impact	-0.67	medium_impact	0.52	0.9	20.8	18.4	0.4	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6555	6555	A	G	MI.3260	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	652	218	T	A	Acc/Gcc	-15.14	0	0	benign	0.03	deleterious	0.02	neutral	2.99	neutral	-0.08	neutral	-0.69	low_impact	1.05	0.68	neutral	0.2	damaging	3.96	23.60	deleterious	0.44	0.55	0.25	neutral	0.5	disease	0.34	neutral	0.44	neutral	1	0.98	neutral	0.5	deleterious	-2	neutral	0.17	neutral	0.66	medium_impact	-0.75	medium_impact	-0.13	medium_impact	0.41	0.9	4.48	10.9	0.43	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6555	6555	A	C	MI.3261	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	652	218	T	P	Acc/Ccc	-15.14	0	0	possibly_damaging	0.46	deleterious	0	neutral	2.94	neutral	-1.11	neutral	-2.38	medium_impact	3.21	0.58	damaging	0.15	damaging	3.98	23.60	deleterious	0.16	0.55	0.4	neutral	0.88	disease	0.6	disease	0.76	disease	5	1	deleterious	0.27	neutral	4	deleterious	0.59	deleterious	-0.69	medium_impact	-1.48	low_impact	1.87	medium_impact	0.54	0.9	4.48	10.9	0.32	N	0.92	polymorphism	0.98	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6556	6556	C	G	MI.3262	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	653	218	T	S	aCc/aGc	3.37	0.99	0	benign	0	neutral	1	neutral	3.29	neutral	1.93	neutral	1.33	neutral_impact	-1.4	0.65	neutral	0.28	damaging	0.82	9.58	deleterious	0.39	0.55	0.18	neutral	0.06	neutral	0.21	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	1.86	high_impact	-2.39	low_impact	0.71	0.9	4.48	10.9	0.43	N	0.79	disease_causing	0.97	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6556	6556	C	T	MI.3263	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	653	218	T	I	aCc/aTc	3.37	0.99	0	possibly_damaging	0.57	deleterious	0	neutral	2.92	neutral	-1.52	deleterious	-3.03	medium_impact	3.21	0.64	neutral	0.13	damaging	4.03	23.60	deleterious	0.29	0.55	0.45	neutral	0.73	disease	0.63	disease	0.7	disease	4	1	deleterious	0.22	neutral	4	deleterious	0.64	deleterious	-0.87	medium_impact	-1.48	low_impact	1.87	medium_impact	0.65	0.9	4.48	10.9	0.4	N	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6556	6556	C	A	MI.3264	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	653	218	T	N	aCc/aAc	3.37	0.99	0	benign	0.2	deleterious	0	neutral	2.95	neutral	-0.92	neutral	-0.93	medium_impact	2.46	0.62	neutral	0.11	damaging	3.72	23.30	deleterious	0.39	0.55	0.3	neutral	0.84	disease	0.62	disease	0.75	disease	5	1	deleterious	0.4	neutral	1	deleterious	0.32	neutral	-0.19	medium_impact	-1.48	low_impact	1.17	medium_impact	0.72	0.9	4.48	10.9	0.39	N	0.80	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6558	6558	T	A	MI.3265	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	655	219	F	I	Ttc/Atc	-13.98	0	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-2.27	deleterious	-5.19	high_impact	3.66	0.63	neutral	0.14	damaging	4.45	24.20	deleterious	0.2	0.55	0.36	neutral	0.8	disease	0.74	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.28	high_impact	0.69	0.9	3.31	7.66	0.3	N	0.88	polymorphism	0.93	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6558	6558	T	G	MI.3266	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	655	219	F	V	Ttc/Gtc	-13.98	0	0	probably_damaging	1	deleterious	0	neutral	2.49	neutral	-2.28	deleterious	-6.06	medium_impact	3.49	0.56	damaging	0.11	damaging	4.16	23.80	deleterious	0.27	0.55	0.45	neutral	0.86	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.12	high_impact	0.59	0.9	3.31	7.66	0.32	N	0.84	polymorphism	0.85	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6558	6558	T	C	MI.3267	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	655	219	F	L	Ttc/Ctc	-13.98	0	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-1.89	deleterious	-5.19	high_impact	4.28	0.53	damaging	0.15	damaging	4.10	23.70	deleterious	0.44	0.55	0.35	neutral	0.8	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.85	high_impact	0.74	0.9	3.31	7.66	0.38	N	0.83	polymorphism	0.92	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6559	6559	T	C	MI.3268	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	656	219	F	S	tTc/tCc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.28	deleterious	-6.92	high_impact	5.25	0.67	neutral	0.14	damaging	4.26	23.90	deleterious	0.22	0.55	0.75	disease	0.88	disease	0.72	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.52	0.9	3.31	7.66	0.72	P	0.84	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6559	6559	T	A	MI.3269	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	656	219	F	Y	tTc/tAc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-3.29	deleterious	-2.6	high_impact	3.94	0.6	damaging	0.11	damaging	4.25	23.90	deleterious	0.28	0.55	0.64	disease	0.78	disease	0.69	disease	0.63	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.54	high_impact	0.75	0.9	3.31	7.66	0.55	P	0.59	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8679	8679	A	T	MI.327	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	153	51	K	N	aaA/aaT	1.05	0	0	benign	0.02	neutral	0.71	neutral	4.36	neutral	-0.43	neutral	-0.35	neutral_impact	-0.64	0.82	neutral	0.87	neutral	-0.91	0.03	neutral	0.61	0.7	0.31	neutral	0.17	neutral	0.2	neutral	0.29	neutral	4	0.24	neutral	0.85	deleterious	-6	neutral	0.15	neutral	0.85	medium_impact	0.51	medium_impact	-1.65	low_impact	0.69	0.9	20.8	18.4	0.33	N	0.48	polymorphism	1	0.01	rs386829045	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6559	6559	T	G	MI.3270	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	656	219	F	C	tTc/tGc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.37	deleterious	-5.05	deleterious	-6.93	high_impact	4.56	0.58	damaging	0.11	damaging	4.14	23.80	deleterious	0.24	0.55	0.86	disease	0.89	disease	0.77	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.11	high_impact	0.42	0.9	3.31	7.66	0.56	P	0.91	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6560	6560	C	A	MI.3271	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	657	219	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-1.89	deleterious	-5.19	high_impact	4.28	0.53	damaging	0.15	damaging	4.70	24.60	deleterious	0.44	0.55	0.35	neutral	0.8	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.85	high_impact	0.74	0.9	3.31	7.66	0.54	P	0.83	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6560	6560	C	G	MI.3272	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	657	219	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-1.89	deleterious	-5.19	high_impact	4.28	0.53	damaging	0.15	damaging	4.40	24.10	deleterious	0.44	0.55	0.35	neutral	0.8	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.85	high_impact	0.74	0.9	3.31	7.66	0.54	P	0.83	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6561	6561	T	G	MI.3273	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	658	220	F	V	Ttc/Gtc	-0.8	0.02	0	probably_damaging	1	deleterious	0	neutral	2.3	deleterious	-3.06	deleterious	-6	high_impact	5.25	0.64	neutral	0.16	damaging	4.06	23.70	deleterious	0.26	0.55	0.75	disease	0.88	disease	0.76	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.66	0.9	5.46	8.27	0.7	P	0.84	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6561	6561	T	A	MI.3274	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	658	220	F	I	Ttc/Atc	-0.8	0.02	0	probably_damaging	0.99	deleterious	0	neutral	2.38	neutral	-2.12	deleterious	-5.15	high_impact	5.25	0.71	neutral	0.18	damaging	4.36	24.10	deleterious	0.21	0.55	0.78	disease	0.82	disease	0.76	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.75	high_impact	0.71	0.9	5.46	8.27	0.69	P	0.88	disease_causing	0.99	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6561	6561	T	C	MI.3275	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	658	220	F	L	Ttc/Ctc	-0.8	0.02	0	probably_damaging	0.99	deleterious	0.03	neutral	2.35	neutral	-2.35	deleterious	-5.15	high_impact	4.45	0.57	damaging	0.19	damaging	4.00	23.60	deleterious	0.42	0.55	0.7	disease	0.81	disease	0.73	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-0.65	medium_impact	3.01	high_impact	0.79	0.9	5.46	8.27	0.45	N	0.83	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6562	6562	T	A	MI.3276	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	659	220	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.99	neutral	0.11	neutral	2.41	neutral	-1.8	neutral	-2.49	medium_impact	2.73	0.69	neutral	0.16	damaging	4.33	24.00	deleterious	0.25	0.55	0.55	disease	0.74	disease	0.48	neutral	0.49	neutral	0	1	deleterious	0.06	neutral	1	deleterious	0.80	deleterious	-2.64	low_impact	-0.31	medium_impact	1.42	medium_impact	0.79	0.9	5.46	8.27	0.57	P	0.59	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6562	6562	T	G	MI.3277	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	659	220	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.23	deleterious	-5.62	deleterious	-6.87	high_impact	5.25	0.67	neutral	0.16	damaging	4.16	23.80	deleterious	0.18	0.55	0.92	disease	0.9	disease	0.77	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.41	0.9	5.46	8.27	0.68	P	0.91	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6562	6562	T	C	MI.3278	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	659	220	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.26	deleterious	-4.18	deleterious	-6.86	high_impact	4.7	0.76	neutral	0.2	damaging	4.30	24.00	deleterious	0.16	0.55	0.72	disease	0.89	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.42	0.9	5.46	8.27	0.62	P	0.84	disease_causing	1	0.48	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6563	6563	C	A	MI.3279	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	660	220	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.99	deleterious	0.03	neutral	2.35	neutral	-2.35	deleterious	-5.15	high_impact	4.45	0.57	damaging	0.19	damaging	4.64	24.50	deleterious	0.42	0.55	0.7	disease	0.81	disease	0.73	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-0.65	medium_impact	3.01	high_impact	0.79	0.9	5.46	8.27	0.6	P	0.83	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8679	8679	A	C	MI.328	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	153	51	K	N	aaA/aaC	1.05	0	0	benign	0.02	neutral	0.71	neutral	4.36	neutral	-0.43	neutral	-0.35	neutral_impact	-0.64	0.82	neutral	0.87	neutral	-0.97	0.02	neutral	0.61	0.7	0.31	neutral	0.17	neutral	0.2	neutral	0.29	neutral	4	0.24	neutral	0.85	deleterious	-6	neutral	0.15	neutral	0.85	medium_impact	0.51	medium_impact	-1.65	low_impact	0.69	0.9	20.8	18.4	0.33	N	0.48	polymorphism	1	0.01	rs386829045	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6563	6563	C	G	MI.3280	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	660	220	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.99	deleterious	0.03	neutral	2.35	neutral	-2.35	deleterious	-5.15	high_impact	4.45	0.57	damaging	0.19	damaging	4.36	24.10	deleterious	0.42	0.55	0.7	disease	0.81	disease	0.73	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-0.65	medium_impact	3.01	high_impact	0.79	0.9	5.46	8.27	0.6	P	0.83	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6564	6564	G	A	MI.3281	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	661	221	D	N	Gac/Aac	-3.8	0	0	probably_damaging	0.99	deleterious	0	neutral	2.81	neutral	-1.31	deleterious	-4.3	medium_impact	3.46	0.49	damaging	0.1	damaging	4.19	23.80	deleterious	0.45	0.55	0.29	neutral	0.9	disease	0.49	neutral	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	2.1	high_impact	0.58	0.9	6.43	8.01	0.35	N	0.89	polymorphism	0.64	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6564	6564	G	T	MI.3282	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	661	221	D	Y	Gac/Tac	-3.8	0	0	probably_damaging	1	deleterious	0	neutral	2.81	deleterious	-3.9	deleterious	-7.76	high_impact	4.16	0.57	damaging	0.1	damaging	3.90	23.50	deleterious	0.2	0.55	0.75	disease	0.95	disease	0.67	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.74	high_impact	0.40	0.9	6.43	8.01	0.32	N	0.94	disease_causing	0.86	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6564	6564	G	C	MI.3283	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	661	221	D	H	Gac/Cac	-3.8	0	0	probably_damaging	1	deleterious	0	neutral	2.76	deleterious	-3.13	deleterious	-6.04	high_impact	4.86	0.5	damaging	0.11	damaging	3.62	23.20	deleterious	0.24	0.55	0.64	disease	0.92	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.45	0.9	6.43	8.01	0.6	P	0.97	disease_causing	0.75	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6565	6565	A	C	MI.3284	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	662	221	D	A	gAc/gCc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.87	neutral	-1.24	deleterious	-6.89	high_impact	3.92	0.68	neutral	0.13	damaging	4.17	23.80	deleterious	0.2	0.55	0.41	neutral	0.89	disease	0.65	disease	0.51	disease	0	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.52	high_impact	0.48	0.9	6.43	8.01	0.48	N	0.85	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6565	6565	A	T	MI.3285	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	662	221	D	V	gAc/gTc	7.3	1	0	probably_damaging	1	deleterious	0.03	neutral	2.86	neutral	-2.26	deleterious	-7.76	high_impact	4.16	0.54	damaging	0.1	damaging	4.36	24.10	deleterious	0.18	0.55	0.64	disease	0.95	disease	0.67	disease	0.79	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.65	medium_impact	2.74	high_impact	0.35	0.9	6.43	8.01	0.48	N	0.93	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6565	6565	A	G	MI.3286	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	662	221	D	G	gAc/gGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-2.05	deleterious	-6.04	high_impact	5.2	0.55	damaging	0.12	damaging	4.56	24.40	deleterious	0.19	0.55	0.59	disease	0.9	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.39	0.9	6.43	8.01	0.68	P	0.85	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6566	6566	C	A	MI.3287	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	663	221	D	E	gaC/gaA	6.84	1	0	probably_damaging	0.97	deleterious	0.01	neutral	2.79	neutral	-1	deleterious	-3.44	medium_impact	3.11	0.48	damaging	0.14	damaging	4.21	23.90	deleterious	0.39	0.55	0.25	neutral	0.84	disease	0.31	neutral	0.47	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-2.18	low_impact	-0.92	medium_impact	1.77	medium_impact	0.49	0.9	6.43	8.01	0.52	P	0.65	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6566	6566	C	G	MI.3288	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	663	221	D	E	gaC/gaG	6.84	1	0	probably_damaging	0.97	deleterious	0.01	neutral	2.79	neutral	-1	deleterious	-3.44	medium_impact	3.11	0.48	damaging	0.14	damaging	3.89	23.50	deleterious	0.39	0.55	0.25	neutral	0.84	disease	0.31	neutral	0.47	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-2.18	low_impact	-0.92	medium_impact	1.77	medium_impact	0.49	0.9	6.43	8.01	0.52	P	0.65	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6567	6567	C	G	MI.3289	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	664	222	P	A	Ccc/Gcc	-1.03	0.02	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-1.69	deleterious	-6.78	high_impact	3.65	0.69	neutral	0.07	damaging	3.09	22.50	deleterious	0.24	0.55	0.42	neutral	0.75	disease	0.58	disease	0.59	disease	2	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.27	high_impact	0.80	0.9	2.53	6.7	0.3	N	0.76	disease_causing	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8680	8680	C	G	MI.329	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	154	52	L	V	Cta/Gta	-1.03	0	0	benign	0.32	neutral	0.58	neutral	4.36	neutral	-0.54	neutral	-1.72	low_impact	1.07	0.92	neutral	0.6	neutral	-0.08	1.88	neutral	0.51	0.65	0.59	disease	0.33	neutral	0.28	neutral	0.6	disease	2	0.33	neutral	0.63	deleterious	-6	neutral	0.46	deleterious	-0.45	medium_impact	0.37	medium_impact	-0.18	medium_impact	0.58	0.9	12.83	8.79	0.28	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6567	6567	C	T	MI.3290	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	664	222	P	S	Ccc/Tcc	-1.03	0.02	0	probably_damaging	1	deleterious	0.03	neutral	2.73	neutral	-2.72	deleterious	-6.81	high_impact	3.8	0.69	neutral	0.05	damaging	3.88	23.50	deleterious	0.32	0.55	0.48	neutral	0.87	disease	0.66	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-0.65	medium_impact	2.41	high_impact	0.21	0.9	2.53	6.7	0.33	N	0.85	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6567	6567	C	A	MI.3291	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	664	222	P	T	Ccc/Acc	-1.03	0.02	0	probably_damaging	1	deleterious	0.04	neutral	2.74	neutral	-2.35	deleterious	-6.79	high_impact	4.09	0.67	neutral	0.06	damaging	3.84	23.40	deleterious	0.3	0.55	0.48	neutral	0.87	disease	0.66	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-0.58	medium_impact	2.68	high_impact	0.75	0.9	2.53	6.7	0.35	N	0.80	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6568	6568	C	T	MI.3292	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	665	222	P	L	cCc/cTc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-1.58	deleterious	-8.51	high_impact	4.7	0.7	neutral	0.03	damaging	4.43	24.20	deleterious	0.29	0.55	0.37	neutral	0.9	disease	0.65	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.71	0.9	2.53	6.7	0.56	P	0.87	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6568	6568	C	A	MI.3293	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	665	222	P	H	cCc/cAc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.7	deleterious	-3.45	deleterious	-7.69	high_impact	4.89	0.69	neutral	0.04	damaging	4.04	23.70	deleterious	0.22	0.55	0.74	disease	0.89	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.68	0.9	2.53	6.7	0.66	P	0.81	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6568	6568	C	G	MI.3294	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	665	222	P	R	cCc/cGc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.81	deleterious	-7.69	high_impact	5.25	0.67	neutral	0.04	damaging	3.64	23.20	deleterious	0.26	0.55	0.64	disease	0.92	disease	0.75	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.70	0.9	2.53	6.7	0.66	P	0.90	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6570	6570	G	A	MI.3295	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	667	223	A	T	Gcc/Acc	-10.51	0	0	benign	0	neutral	0.05	neutral	2.84	neutral	-1.12	neutral	-2.33	low_impact	1.64	0.55	damaging	0.5	neutral	1.20	11.74	neutral	0.39	0.55	0.38	neutral	0.79	disease	0.25	neutral	0.46	neutral	1	0.95	neutral	0.53	deleterious	-6	neutral	0.22	neutral	2.07	high_impact	-0.52	medium_impact	0.42	medium_impact	0.74	0.9	11.89	33.63	0.48	N	0.62	polymorphism	0.96	0.08	rs386828988	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6570	6570	G	T	MI.3296	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	667	223	A	S	Gcc/Tcc	-10.51	0	0	benign	0.07	neutral	0.48	neutral	2.92	neutral	-0.9	neutral	-1.36	neutral_impact	0.24	0.57	damaging	0.63	neutral	0.33	5.97	deleterious	0.4	0.55	0.37	neutral	0.43	neutral	0.18	neutral	0.45	neutral	1	0.46	neutral	0.71	deleterious	-6	neutral	0.21	neutral	0.3	medium_impact	0.17	medium_impact	-0.88	medium_impact	0.76	0.9	11.89	33.63	0.48	N	0.30	polymorphism	0.98	0.03	.	.	.	.	.	.	COSM6716191	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6570	6570	G	C	MI.3297	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	667	223	A	P	Gcc/Ccc	-10.51	0	0	benign	0.3	deleterious	0	neutral	2.79	deleterious	-3.15	deleterious	-3.52	high_impact	4.08	0.61	neutral	0.38	neutral	2.03	16.42	deleterious	0.17	0.55	0.73	disease	0.91	disease	0.47	neutral	0.72	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.65	deleterious	-0.41	medium_impact	-1.48	low_impact	2.67	high_impact	0.72	0.9	11.89	33.63	0.4	N	0.73	polymorphism	0.87	0.18	rs386828988	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6571	6571	C	T	MI.3298	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	668	223	A	V	gCc/gTc	4.29	1	0	benign	0	neutral	0.06	neutral	2.87	neutral	-1.52	deleterious	-2.86	medium_impact	2.27	0.58	damaging	0.5	neutral	2.54	19.73	deleterious	0.32	0.55	0.42	neutral	0.79	disease	0.26	neutral	0.49	neutral	0	0.94	neutral	0.53	deleterious	-3	neutral	0.22	neutral	2.07	high_impact	-0.47	medium_impact	1	medium_impact	0.72	0.9	11.89	33.63	0.53	P	0.17	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6571	6571	C	A	MI.3299	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	668	223	A	D	gCc/gAc	4.29	1	0	benign	0.24	deleterious	0	neutral	2.8	neutral	-1.36	deleterious	-3.98	medium_impact	2.84	0.63	neutral	0.43	neutral	2.63	20.40	deleterious	0.24	0.55	0.6	disease	0.89	disease	0.56	disease	0.63	disease	3	1	deleterious	0.38	neutral	1	deleterious	0.54	deleterious	-0.29	medium_impact	-1.48	low_impact	1.52	medium_impact	0.61	0.9	11.89	33.63	0.47	N	0.93	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8540	8540	T	A	MI.33	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	14	5	L	Q	cTg/cAg	-1.95	0	0	probably_damaging	0.99	deleterious	0	neutral	4.11	deleterious	-3.79	deleterious	-4.7	medium_impact	2.93	0.79	neutral	0.44	neutral	3.94	23.50	deleterious	0.25	0.65	0.87	disease	0.59	disease	0.69	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-2.65	low_impact	-1.4	low_impact	1.41	medium_impact	0.66	0.9	50.44	8.42	0.31	N	0.98	polymorphism	0.57	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8680	8680	C	A	MI.330	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	154	52	L	M	Cta/Ata	-1.03	0	0	possibly_damaging	0.85	neutral	0.27	neutral	4.32	neutral	-1.75	neutral	-0.73	neutral_impact	0.64	0.94	neutral	0.74	neutral	2.33	18.36	deleterious	0.38	0.65	0.58	disease	0.21	neutral	0.17	neutral	0.46	neutral	1	0.89	neutral	0.21	neutral	-3	neutral	0.66	deleterious	-1.47	low_impact	0.05	medium_impact	-0.55	medium_impact	0.70	0.9	12.83	8.79	0.52	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6571	6571	C	G	MI.3300	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	668	223	A	G	gCc/gGc	4.29	1	0	benign	0.04	deleterious	0.03	neutral	2.83	neutral	-1.91	deleterious	-2.67	medium_impact	3.04	0.63	neutral	0.61	neutral	2.06	16.62	deleterious	0.22	0.55	0.55	disease	0.72	disease	0.47	neutral	0.48	neutral	0	0.97	neutral	0.5	deleterious	1	deleterious	0.24	neutral	0.54	medium_impact	-0.65	medium_impact	1.71	medium_impact	0.65	0.9	11.89	33.63	0.49	P	0.56	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6573	6573	G	T	MI.3301	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	670	224	G	W	Gga/Tga	-9.59	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-4.91	deleterious	-6.95	high_impact	5.2	0.62	neutral	0.08	damaging	4.45	24.20	deleterious	0.16	0.55	0.86	disease	0.91	disease	0.76	disease	0.8	disease	6	1	deleterious	0	deleterious	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.7	high_impact	0.29	0.9	2.34	6.67	0.57	P	0.83	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6573	6573	G	C	MI.3302	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	670	224	G	R	Gga/Cga	-9.59	0	0	probably_damaging	1	deleterious	0.01	neutral	2.67	neutral	-2.89	deleterious	-6.92	high_impact	5.2	0.61	neutral	0.07	damaging	3.99	23.60	deleterious	0.15	0.55	0.27	neutral	0.93	disease	0.74	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-0.92	medium_impact	3.7	high_impact	0.61	0.9	2.34	6.67	0.55	P	0.95	disease_causing	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6574	6574	G	C	MI.3303	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	671	224	G	A	gGa/gCa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.14	deleterious	-5.19	high_impact	4	0.79	neutral	0.12	damaging	3.15	22.60	deleterious	0.22	0.55	0.29	neutral	0.78	disease	0.65	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.72	deleterious	-3.58	low_impact	-1.48	low_impact	2.59	high_impact	0.33	0.9	2.34	6.67	0.44	N	0.64	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6574	6574	G	T	MI.3304	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	671	224	G	V	gGa/gTa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.03	deleterious	-7.8	high_impact	4.86	0.5	damaging	0.1	damaging	3.85	23.40	deleterious	0.16	0.55	0.49	neutral	0.91	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.44	0.9	2.34	6.67	0.65	P	0.93	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6574	6574	G	A	MI.3305	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	671	224	G	E	gGa/gAa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.82	deleterious	-6.93	high_impact	4.5	0.58	damaging	0.08	damaging	3.91	23.50	deleterious	0.19	0.55	0.16	neutral	0.9	disease	0.76	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.35	0.9	2.34	6.67	0.52	P	0.93	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6576	6576	G	T	MI.3306	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	673	225	G	W	Gga/Tga	-0.8	0.01	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-6.89	deleterious	-6.94	high_impact	5.29	0.62	neutral	0.09	damaging	4.53	24.30	deleterious	0.15	0.55	0.94	disease	0.91	disease	0.78	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.32	0.9	2.73	6.67	0.6	P	0.83	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6576	6576	G	C	MI.3307	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	673	225	G	R	Gga/Cga	-0.8	0.01	0	probably_damaging	1	deleterious	0	neutral	2.58	neutral	-2.86	deleterious	-6.93	high_impact	5.29	0.62	neutral	0.07	damaging	4.02	23.60	deleterious	0.16	0.55	0.66	disease	0.93	disease	0.78	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.64	0.9	2.73	6.67	0.65	P	0.95	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6577	6577	G	C	MI.3308	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	674	225	G	A	gGa/gCa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.69	deleterious	-5.18	high_impact	4	0.77	neutral	0.13	damaging	3.16	22.60	deleterious	0.16	0.55	0.51	disease	0.78	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.59	high_impact	0.41	0.9	2.73	6.67	0.48	N	0.64	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6577	6577	G	A	MI.3309	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	674	225	G	E	gGa/gAa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.23	deleterious	-6.93	high_impact	5.29	0.58	damaging	0.09	damaging	3.92	23.50	deleterious	0.18	0.55	0.4	neutral	0.9	disease	0.77	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.41	0.9	2.73	6.67	0.68	P	0.93	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8681	8681	T	C	MI.331	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	155	52	L	P	cTa/cCa	-1.95	0	0	possibly_damaging	0.8	neutral	0.29	neutral	4.31	neutral	-2.34	deleterious	-3.93	medium_impact	2.08	0.78	neutral	0.3	neutral	2.43	18.98	deleterious	0.17	0.65	0.69	disease	0.78	disease	0.53	disease	0.72	disease	4	0.84	neutral	0.25	neutral	0	NA	0.78	deleterious	-1.33	low_impact	0.07	medium_impact	0.69	medium_impact	0.51	0.9	12.83	8.79	0.25	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6577	6577	G	T	MI.3310	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	674	225	G	V	gGa/gTa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-3.7	deleterious	-7.79	high_impact	4.94	0.51	damaging	0.1	damaging	3.81	23.40	deleterious	0.15	0.55	0.71	disease	0.91	disease	0.69	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.46	high_impact	0.35	0.9	2.73	6.67	0.64	P	0.93	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6579	6579	G	T	MI.3311	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	676	226	G	W	Gga/Tga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-6.1	deleterious	-6.95	high_impact	4.96	0.64	neutral	0.09	damaging	4.53	24.30	deleterious	0.18	0.55	0.97	disease	0.91	disease	0.72	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.26	0.9	2.53	7.28	0.56	P	0.83	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6579	6579	G	C	MI.3312	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	676	226	G	R	Gga/Cga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-4.04	deleterious	-6.95	high_impact	5.31	0.63	neutral	0.07	damaging	4.02	23.60	deleterious	0.15	0.55	0.77	disease	0.93	disease	0.81	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.61	0.9	2.53	7.28	0.64	P	0.95	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6580	6580	G	C	MI.3313	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	677	226	G	A	gGa/gCa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-2.85	deleterious	-5.21	high_impact	4.96	0.62	neutral	0.15	damaging	3.16	22.60	deleterious	0.18	0.55	0.68	disease	0.76	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.44	0.9	2.53	7.28	0.72	P	0.64	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6580	6580	G	T	MI.3314	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	677	226	G	V	gGa/gTa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-1.34	deleterious	-7.82	high_impact	5.31	0.61	neutral	0.09	damaging	3.81	23.40	deleterious	0.16	0.55	0.78	disease	0.91	disease	0.73	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.39	0.9	2.53	7.28	0.7	P	0.93	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6580	6580	G	A	MI.3315	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	677	226	G	E	gGa/gAa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.9	deleterious	-6.95	high_impact	5.31	0.59	damaging	0.09	damaging	3.90	23.50	deleterious	0.15	0.55	0.35	neutral	0.88	disease	0.8	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.44	0.9	2.53	7.28	0.68	P	0.93	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6582	6582	G	C	MI.3316	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	679	227	D	H	Gac/Cac	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.4	deleterious	-6.04	high_impact	4.89	0.52	damaging	0.1	damaging	3.70	23.30	deleterious	0.32	0.55	0.71	disease	0.91	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.50	0.9	2.53	7.06	0.6	P	0.97	disease_causing	0.99	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6582	6582	G	A	MI.3317	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	679	227	D	N	Gac/Aac	-1.95	0	0	probably_damaging	1	neutral	0.11	neutral	2.74	neutral	-1.03	deleterious	-4.31	medium_impact	3.5	0.53	damaging	0.1	damaging	4.25	23.90	deleterious	0.46	0.55	0.24	neutral	0.89	disease	0.55	disease	0.64	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.31	medium_impact	2.13	high_impact	0.71	0.9	2.53	7.06	0.33	N	0.89	disease_causing	0.95	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6582	6582	G	T	MI.3318	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	679	227	D	Y	Gac/Tac	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-5.32	deleterious	-7.77	high_impact	5.24	0.62	neutral	0.09	damaging	3.97	23.60	deleterious	0.22	0.55	0.79	disease	0.96	disease	0.73	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.33	0.9	2.53	7.06	0.53	P	0.94	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6583	6583	A	G	MI.3319	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	680	227	D	G	gAc/gGc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3	deleterious	-6.04	high_impact	4.54	0.6	damaging	0.12	damaging	3.97	23.60	deleterious	0.21	0.55	0.65	disease	0.88	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.09	high_impact	0.29	0.9	2.53	7.06	0.54	P	0.85	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8681	8681	T	G	MI.332	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	155	52	L	R	cTa/cGa	-1.95	0	0	benign	0.02	neutral	0.56	neutral	4.35	neutral	-0.8	neutral	-2.09	neutral_impact	0.16	0.82	neutral	0.65	neutral	-0.02	2.37	deleterious	0.25	0.65	0.75	disease	0.46	neutral	0.32	neutral	0.62	disease	2	0.41	neutral	0.77	deleterious	-6	neutral	0.28	neutral	0.85	medium_impact	0.35	medium_impact	-0.96	medium_impact	0.63	0.9	12.83	8.79	0.22	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6583	6583	A	T	MI.3320	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	680	227	D	V	gAc/gTc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.47	deleterious	-5.09	deleterious	-7.77	high_impact	4.89	0.49	damaging	0.12	damaging	3.73	23.30	deleterious	0.22	0.55	0.54	disease	0.94	disease	0.7	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.21	0.9	2.53	7.06	0.58	P	0.93	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6583	6583	A	C	MI.3321	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	680	227	D	A	gAc/gCc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-3.69	deleterious	-6.89	high_impact	4.89	0.72	neutral	0.13	damaging	3.63	23.20	deleterious	0.22	0.55	0.41	neutral	0.89	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.40	0.9	2.53	7.06	0.64	P	0.85	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6584	6584	C	G	MI.3322	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	681	227	D	E	gaC/gaG	6.84	1	0	probably_damaging	0.98	deleterious	0.03	neutral	2.52	deleterious	-3.19	deleterious	-3.45	high_impact	5.24	0.6	neutral	0.11	damaging	3.90	23.50	deleterious	0.4	0.55	0.43	neutral	0.84	disease	0.56	disease	0.68	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-0.65	medium_impact	3.74	high_impact	0.54	0.9	2.53	7.06	0.66	P	0.65	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6584	6584	C	A	MI.3323	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	681	227	D	E	gaC/gaA	6.84	1	0	probably_damaging	0.98	deleterious	0.03	neutral	2.52	deleterious	-3.19	deleterious	-3.45	high_impact	5.24	0.6	neutral	0.11	damaging	4.21	23.90	deleterious	0.4	0.55	0.43	neutral	0.84	disease	0.56	disease	0.68	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-0.65	medium_impact	3.74	high_impact	0.54	0.9	2.53	7.06	0.67	P	0.65	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6585	6585	C	T	MI.3324	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	682	228	P	S	Ccc/Tcc	-2.65	0	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-2.75	deleterious	-6.93	high_impact	4.26	0.57	damaging	0.11	damaging	3.89	23.50	deleterious	0.28	0.55	0.72	disease	0.84	disease	0.62	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.26	0.9	2.73	6.69	0.32	N	0.85	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6585	6585	C	A	MI.3325	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	682	228	P	T	Ccc/Acc	-2.65	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-2.87	deleterious	-6.93	high_impact	4.34	0.63	neutral	0.07	damaging	3.85	23.40	deleterious	0.23	0.55	0.64	disease	0.86	disease	0.62	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.91	high_impact	0.63	0.9	2.73	6.69	0.33	N	0.80	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6585	6585	C	G	MI.3326	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	682	228	P	A	Ccc/Gcc	-2.65	0	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	-1.54	deleterious	-6.93	medium_impact	3.42	0.68	neutral	0.11	damaging	3.11	22.50	deleterious	0.21	0.55	0.68	disease	0.78	disease	0.53	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.06	high_impact	0.66	0.9	2.73	6.69	0.27	N	0.76	disease_causing	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6586	6586	C	T	MI.3327	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	683	228	P	L	cCc/cTc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-2.64	deleterious	-8.67	high_impact	3.65	0.5	damaging	0.1	damaging	4.44	24.20	deleterious	0.25	0.55	0.75	disease	0.9	disease	0.6	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.27	high_impact	0.66	0.9	2.73	6.69	0.46	N	0.87	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6586	6586	C	A	MI.3328	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	683	228	P	H	cCc/cAc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-4.6	deleterious	-7.8	high_impact	5.24	0.63	neutral	0.06	damaging	4.08	23.70	deleterious	0.16	0.55	0.94	disease	0.9	disease	0.73	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.51	0.9	2.73	6.69	0.63	P	0.81	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6586	6586	C	G	MI.3329	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	683	228	P	R	cCc/cGc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.66	deleterious	-7.8	high_impact	5.24	0.6	damaging	0.05	damaging	3.64	23.20	deleterious	0.2	0.55	0.87	disease	0.94	disease	0.75	disease	0.83	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.44	0.9	2.73	6.69	0.62	P	0.90	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8681	8681	T	A	MI.333	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	155	52	L	Q	cTa/cAa	-1.95	0	0	possibly_damaging	0.52	neutral	0.48	neutral	4.39	neutral	-0.07	deleterious	-2.6	low_impact	1.01	0.89	neutral	0.51	neutral	0.99	10.58	neutral	0.24	0.65	0.72	disease	0.46	neutral	0.19	neutral	0.61	disease	2	0.53	neutral	0.48	deleterious	-3	neutral	0.63	deleterious	-0.79	medium_impact	0.27	medium_impact	-0.23	medium_impact	0.58	0.9	12.83	8.79	0.36	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6588	6588	A	T	MI.3330	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	685	229	I	F	Att/Ttt	-12.83	0	0	possibly_damaging	0.55	deleterious	0	neutral	2.68	neutral	-2.58	deleterious	-3.44	high_impact	4.39	0.56	damaging	0.11	damaging	4.04	23.70	deleterious	0.21	0.55	0.73	disease	0.85	disease	0.44	neutral	0.7	disease	4	1	deleterious	0.23	neutral	5	deleterious	0.62	deleterious	-0.84	medium_impact	-1.48	low_impact	2.95	high_impact	0.75	0.9	6.63	9.18	0.37	N	0.85	disease_causing	0.54	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6588	6588	A	G	MI.3331	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	685	229	I	V	Att/Gtt	-12.83	0	0	benign	0	neutral	0.28	neutral	2.92	neutral	-0.24	neutral	-0.64	low_impact	0.98	0.67	neutral	0.87	neutral	1.80	15.00	deleterious	0.43	0.55	0.16	neutral	0.24	neutral	0.21	neutral	0.38	neutral	2	0.72	neutral	0.64	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	-0.04	medium_impact	-0.19	medium_impact	0.64	0.9	6.63	9.18	0.53	N	0.23	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6588	6588	A	C	MI.3332	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	685	229	I	L	Att/Ctt	-12.83	0	0	benign	0.07	neutral	0.19	neutral	3	neutral	0.7	neutral	-1.72	medium_impact	2.96	0.63	neutral	0.12	damaging	3.85	23.40	deleterious	0.29	0.55	0.24	neutral	0.68	disease	0.24	neutral	0.44	neutral	1	0.79	neutral	0.56	deleterious	-3	neutral	0.16	neutral	0.3	medium_impact	-0.16	medium_impact	1.63	medium_impact	0.69	0.9	6.63	9.18	0.39	N	0.61	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6589	6589	T	C	MI.3333	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	686	229	I	T	aTt/aCt	2.67	0.98	0	possibly_damaging	0.9	deleterious	0	neutral	2.76	neutral	-2.19	deleterious	-4.08	high_impact	4.25	0.6	damaging	0.15	damaging	3.38	23.00	deleterious	0.24	0.55	0.74	disease	0.79	disease	0.56	disease	0.66	disease	3	1	deleterious	0.05	neutral	5	deleterious	0.52	deleterious	-1.65	low_impact	-1.48	low_impact	2.83	high_impact	0.44	0.9	6.63	9.18	0.49	P	0.76	polymorphism	0.98	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6589	6589	T	A	MI.3334	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	686	229	I	N	aTt/aAt	2.67	0.98	0	probably_damaging	0.99	deleterious	0	neutral	2.66	deleterious	-3.76	deleterious	-5.93	high_impact	4.95	0.64	neutral	0.15	damaging	4.43	24.20	deleterious	0.17	0.55	0.91	disease	0.91	disease	0.57	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.47	high_impact	0.57	0.9	6.63	9.18	0.68	P	0.94	polymorphism	0.95	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6589	6589	T	G	MI.3335	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	686	229	I	S	aTt/aGt	2.67	0.98	0	probably_damaging	0.97	deleterious	0	neutral	2.69	neutral	-2.37	deleterious	-5.05	high_impact	4.95	0.65	neutral	0.17	damaging	4.36	24.10	deleterious	0.15	0.55	0.84	disease	0.85	disease	0.57	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.69	deleterious	-2.18	low_impact	-1.48	low_impact	3.47	high_impact	0.50	0.9	6.63	9.18	0.68	P	0.62	polymorphism	0.94	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6590	6590	T	G	MI.3336	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	687	229	I	M	atT/atG	7.53	1	0	possibly_damaging	0.78	deleterious	0	neutral	2.72	neutral	-1.35	neutral	-2.47	high_impact	3.53	0.65	neutral	0.15	damaging	3.44	23.00	deleterious	0.28	0.55	0.38	neutral	0.66	disease	0.56	disease	0.63	disease	3	1	deleterious	0.11	neutral	5	deleterious	0.34	neutral	-1.27	low_impact	-1.48	low_impact	2.16	high_impact	0.77	0.9	6.63	9.18	0.51	P	0.76	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6590	6590	T	A	MI.3337	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	687	229	I	M	atT/atA	7.53	1	0	possibly_damaging	0.78	deleterious	0	neutral	2.72	neutral	-1.35	neutral	-2.47	high_impact	3.53	0.65	neutral	0.15	damaging	3.79	23.40	deleterious	0.28	0.55	0.38	neutral	0.66	disease	0.56	disease	0.63	disease	3	1	deleterious	0.11	neutral	5	deleterious	0.34	neutral	-1.27	low_impact	-1.48	low_impact	2.16	high_impact	0.77	0.9	6.63	9.18	0.52	P	0.76	polymorphism	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6591	6591	C	G	MI.3338	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	688	230	L	V	Cta/Gta	-6.58	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.61	neutral	-2.7	deleterious	-2.6	high_impact	4.19	0.5	damaging	0.12	damaging	3.44	23.00	deleterious	0.2	0.55	0.43	neutral	0.75	disease	0.47	neutral	0.56	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-0.92	medium_impact	2.77	high_impact	0.60	0.9	2.53	6.67	0.33	N	0.66	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6591	6591	C	A	MI.3339	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	688	230	L	M	Cta/Ata	-6.58	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.24	neutral	-1.73	high_impact	4	0.61	neutral	0.17	damaging	3.75	23.30	deleterious	0.16	0.55	0.67	disease	0.64	disease	0.43	neutral	0.49	neutral	0	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.59	high_impact	0.65	0.9	2.53	6.67	0.37	N	0.59	polymorphism	1	0.08	rs28483589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8683	8683	A	T	MI.334	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	157	53	T	S	Acc/Tcc	-12.37	0	0	benign	0.14	neutral	0.05	neutral	4.31	neutral	-1.75	neutral	-1.38	low_impact	0.88	0.84	neutral	0.65	neutral	0.27	5.43	deleterious	0.39	0.65	0.57	disease	0.23	neutral	0.43	neutral	0.54	disease	1	0.94	neutral	0.46	neutral	-6	neutral	0.26	neutral	-0.01	medium_impact	-0.43	medium_impact	-0.34	medium_impact	0.69	0.9	11.95	17.19	0.45	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6592	6592	T	G	MI.3340	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	689	230	L	R	cTa/cGa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-5.3	deleterious	-5.2	high_impact	5.29	0.54	damaging	0.11	damaging	4.15	23.80	deleterious	0.1	0.55	0.79	disease	0.93	disease	0.72	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.37	0.9	2.53	6.67	0.59	P	0.90	polymorphism	0.88	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6592	6592	T	C	MI.3341	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	689	230	L	P	cTa/cCa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.47	deleterious	-5.94	deleterious	-6.07	high_impact	5.29	0.42	damaging	0.17	damaging	3.87	23.50	deleterious	0.11	0.55	0.85	disease	0.85	disease	0.72	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.48	0.9	2.53	6.67	0.62	P	0.83	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6592	6592	T	A	MI.3342	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	689	230	L	Q	cTa/cAa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.47	deleterious	-5.42	deleterious	-5.2	high_impact	5.29	0.54	damaging	0.12	damaging	4.06	23.70	deleterious	0.11	0.55	0.81	disease	0.84	disease	0.59	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.61	0.9	2.53	6.67	0.6	P	0.82	polymorphism	0.9	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6594	6594	T	A	MI.3343	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	691	231	Y	N	Tac/Aac	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-2.4	deleterious	-6.97	high_impact	4.87	0.6	damaging	0.06	damaging	4.02	23.60	deleterious	0.13	0.55	0.7	disease	0.88	disease	0.59	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.4	high_impact	0.38	0.9	3.7	6.65	0.58	P	0.94	polymorphism	0.89	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6594	6594	T	G	MI.3344	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	691	231	Y	D	Tac/Gac	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.83	deleterious	-3.83	deleterious	-7.59	high_impact	4.87	0.57	damaging	0.05	damaging	3.94	23.50	deleterious	0.1	0.55	0.77	disease	0.87	disease	0.69	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.4	high_impact	0.41	0.9	3.7	6.65	0.57	P	0.98	polymorphism	0.92	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6594	6594	T	C	MI.3345	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	691	231	Y	H	Tac/Cac	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.77	deleterious	-3.43	deleterious	-4.05	high_impact	4.87	0.62	neutral	0.05	damaging	3.57	23.20	deleterious	0.13	0.55	0.74	disease	0.82	disease	0.7	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.4	high_impact	0.45	0.9	3.7	6.65	0.64	P	0.61	polymorphism	0.99	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6595	6595	A	T	MI.3346	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	692	231	Y	F	tAc/tTc	7.53	1	0	probably_damaging	1	neutral	0.43	neutral	2.89	neutral	-0.39	neutral	-1.65	neutral_impact	0.74	0.5	damaging	0.1	damaging	2.19	17.47	deleterious	0.21	0.55	0.44	neutral	0.41	neutral	0.26	neutral	0.41	neutral	2	1	deleterious	0.22	neutral	-2	neutral	0.73	deleterious	-3.58	low_impact	0.13	medium_impact	-0.42	medium_impact	0.60	0.9	3.7	6.65	0.58	P	0.50	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6595	6595	A	G	MI.3347	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	692	231	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.76	deleterious	-3.74	deleterious	-6.73	high_impact	4.87	0.58	damaging	0.05	damaging	3.48	23.10	deleterious	0.13	0.55	0.76	disease	0.89	disease	0.64	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.4	high_impact	0.33	0.9	3.7	6.65	0.64	P	0.89	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6595	6595	A	C	MI.3348	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	692	231	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.81	neutral	-1.27	deleterious	-6.71	high_impact	4.07	0.6	neutral	0.07	damaging	3.69	23.30	deleterious	0.11	0.55	0.43	neutral	0.81	disease	0.59	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.66	high_impact	0.46	0.9	3.7	6.65	0.44	N	0.90	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6597	6597	C	G	MI.3349	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	694	232	Q	E	Caa/Gaa	-4.5	0	0	probably_damaging	0.98	deleterious	0.01	neutral	2.79	neutral	-1.04	deleterious	-2.55	high_impact	3.89	0.66	neutral	0.14	damaging	3.08	22.50	deleterious	0.34	0.55	0.37	neutral	0.77	disease	0.61	disease	0.62	disease	2	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-0.92	medium_impact	2.49	high_impact	0.71	0.9	2.53	6.9	0.32	N	0.72	polymorphism	0.98	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8683	8683	A	C	MI.335	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	157	53	T	P	Acc/Ccc	-12.37	0	0	possibly_damaging	0.48	deleterious	0.02	neutral	4.28	deleterious	-3.23	deleterious	-3.03	medium_impact	2.12	0.78	neutral	0.36	neutral	3.03	22.30	deleterious	0.17	0.65	0.84	disease	0.69	disease	0.75	disease	0.82	disease	6	0.98	neutral	0.27	neutral	4	deleterious	0.67	deleterious	-0.72	medium_impact	-0.66	medium_impact	0.72	medium_impact	0.61	0.9	11.95	17.19	0.3	N	0.82	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6597	6597	C	A	MI.3350	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	694	232	Q	K	Caa/Aaa	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-1.13	deleterious	-3.4	high_impact	4.92	0.64	neutral	0.12	damaging	4.11	23.70	deleterious	0.31	0.55	0.44	neutral	0.89	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.57	0.9	2.53	6.9	0.6	P	0.83	polymorphism	0.97	0.27	.	.	.	.	.	.	.	.	.	C6597A	MELAS-like syndrome	-	+	Reported	1	.	P	P	damaging
chrM	6598	6598	A	G	MI.3351	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	695	232	Q	R	cAa/cGa	7.3	1	0	probably_damaging	1	deleterious	0.01	neutral	2.69	neutral	-1.88	deleterious	-3.4	high_impact	5.28	0.68	neutral	0.12	damaging	3.57	23.10	deleterious	0.35	0.55	0.41	neutral	0.91	disease	0.72	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-0.92	medium_impact	3.78	high_impact	0.52	0.9	2.53	6.9	0.7	P	0.76	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6598	6598	A	C	MI.3352	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	695	232	Q	P	cAa/cCa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-4.52	deleterious	-5.12	high_impact	5.28	0.61	neutral	0.14	damaging	3.36	22.90	deleterious	0.15	0.55	0.77	disease	0.89	disease	0.76	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.61	0.9	2.53	6.9	0.71	P	0.84	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6598	6598	A	T	MI.3353	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	695	232	Q	L	cAa/cTa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-3.43	deleterious	-5.93	high_impact	4.92	0.67	neutral	0.13	damaging	3.88	23.50	deleterious	0.12	0.55	0.69	disease	0.9	disease	0.6	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.33	0.9	2.53	6.9	0.69	P	0.71	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6599	6599	A	T	MI.3354	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	696	232	Q	H	caA/caT	6.84	1	0.01	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-5.45	deleterious	-4.25	high_impact	4.92	0.57	damaging	0.15	damaging	3.69	23.30	deleterious	0.3	0.55	0.73	disease	0.85	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.72	0.9	2.53	6.9	0.7	P	0.70	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6599	6599	A	C	MI.3355	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	696	232	Q	H	caA/caC	6.84	1	0.01	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-5.45	deleterious	-4.25	high_impact	4.92	0.57	damaging	0.15	damaging	3.50	23.10	deleterious	0.3	0.55	0.73	disease	0.85	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.72	0.9	2.53	6.9	0.7	P	0.70	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6600	6600	C	T	MI.3356	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	697	233	H	Y	Cac/Tac	1.05	1	0	probably_damaging	1	deleterious	0	neutral	2.79	deleterious	-3.98	deleterious	-5.15	high_impact	4.6	0.6	neutral	0.09	damaging	3.71	23.30	deleterious	0.2	0.55	0.81	disease	0.9	disease	0.73	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.15	high_impact	0.49	0.9	2.34	6.97	0.47	N	0.72	disease_causing	0.99	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6600	6600	C	G	MI.3357	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	697	233	H	D	Cac/Gac	1.05	1	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.02	deleterious	-7.72	high_impact	4.6	0.59	damaging	0.1	damaging	3.86	23.50	deleterious	0.16	0.55	0.55	disease	0.85	disease	0.78	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.15	high_impact	0.54	0.9	2.34	6.97	0.56	P	0.97	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6600	6600	C	A	MI.3358	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	697	233	H	N	Cac/Aac	1.05	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-1.57	deleterious	-5.99	high_impact	4.75	0.52	damaging	0.12	damaging	4.02	23.60	deleterious	0.21	0.55	0.39	neutral	0.88	disease	0.71	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.64	0.9	2.34	6.97	0.59	P	0.86	disease_causing	0.99	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6601	6601	A	C	MI.3359	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	698	233	H	P	cAc/cCc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-4.16	deleterious	-8.59	high_impact	5.29	0.53	damaging	0.11	damaging	3.15	22.60	deleterious	0.17	0.55	0.36	neutral	0.89	disease	0.8	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.48	0.9	2.34	6.97	0.6	P	0.90	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8683	8683	A	G	MI.336	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	157	53	T	A	Acc/Gcc	-12.37	0	0	benign	0.01	neutral	0.2	neutral	4.34	neutral	-0.94	neutral	-1.36	neutral_impact	0.36	0.97	neutral	0.84	neutral	0.32	5.87	deleterious	0.49	0.65	0.5	neutral	0.19	neutral	0.45	neutral	0.26	neutral	5	0.8	neutral	0.6	deleterious	-6	neutral	0.14	neutral	1.14	medium_impact	-0.05	medium_impact	-0.79	medium_impact	0.39	0.9	11.95	17.19	0.43	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6601	6601	A	T	MI.3360	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	698	233	H	L	cAc/cTc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.81	neutral	-2.47	deleterious	-9.44	high_impact	4.49	0.63	neutral	0.09	damaging	3.71	23.30	deleterious	0.15	0.55	0.68	disease	0.91	disease	0.71	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.05	high_impact	0.42	0.9	2.34	6.97	0.57	P	0.92	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6601	6601	A	G	MI.3361	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	698	233	H	R	cAc/cGc	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.88	deleterious	-6.86	high_impact	4.39	0.59	damaging	0.09	damaging	2.91	21.90	deleterious	0.23	0.55	0.57	disease	0.89	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.56	0.9	2.34	6.97	0.47	N	0.85	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6602	6602	C	G	MI.3362	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	699	233	H	Q	caC/caG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.63	deleterious	-6.85	high_impact	5.29	0.64	neutral	0.1	damaging	3.64	23.20	deleterious	0.23	0.55	0.48	neutral	0.82	disease	0.66	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.58	0.9	2.34	6.97	0.67	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6602	6602	C	A	MI.3363	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	699	233	H	Q	caC/caA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.63	deleterious	-6.85	high_impact	5.29	0.64	neutral	0.1	damaging	3.98	23.60	deleterious	0.23	0.55	0.48	neutral	0.82	disease	0.66	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.58	0.9	2.34	6.97	0.67	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6603	6603	C	G	MI.3364	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	700	234	L	V	Cta/Gta	0.13	0.02	0	probably_damaging	0.98	deleterious	0	neutral	2.48	neutral	-2.96	deleterious	-2.59	high_impact	4.24	0.52	damaging	0.06	damaging	3.43	23.00	deleterious	0.34	0.55	0.61	disease	0.76	disease	0.64	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-1.48	low_impact	2.82	high_impact	0.58	0.9	2.53	6.72	0.34	N	0.66	disease_causing	0.97	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6603	6603	C	A	MI.3365	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	700	234	L	M	Cta/Ata	0.13	0.02	0	probably_damaging	1	neutral	0.06	neutral	2.39	deleterious	-4.15	neutral	-1.72	high_impact	3.81	0.56	damaging	0.08	damaging	3.96	23.60	deleterious	0.25	0.55	0.56	disease	0.65	disease	0.52	disease	0.56	disease	1	1	deleterious	0.03	neutral	2	deleterious	0.74	deleterious	-3.58	low_impact	-0.47	medium_impact	2.42	high_impact	0.59	0.9	2.53	6.72	0.36	N	0.59	disease_causing	0.97	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6604	6604	T	G	MI.3366	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	701	234	L	R	cTa/cGa	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.31	deleterious	-5.27	deleterious	-5.17	high_impact	5.28	0.51	damaging	0.04	damaging	4.25	23.90	deleterious	0.13	0.55	0.43	neutral	0.92	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.46	0.9	2.53	6.72	0.57	P	0.90	polymorphism	0.9	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6604	6604	T	C	MI.3367	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	701	234	L	P	cTa/cCa	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.31	deleterious	-6.01	deleterious	-6.04	high_impact	4.93	0.39	damaging	0.05	damaging	3.96	23.60	deleterious	0.12	0.55	0.91	disease	0.84	disease	0.76	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.42	0.9	2.53	6.72	0.55	P	0.83	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6604	6604	T	A	MI.3368	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	701	234	L	Q	cTa/cAa	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-5.51	deleterious	-5.17	high_impact	4.93	0.54	damaging	0.05	damaging	4.15	23.80	deleterious	0.15	0.55	0.88	disease	0.85	disease	0.65	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.68	0.9	2.53	6.72	0.56	P	0.82	polymorphism	0.92	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6606	6606	T	C	MI.3369	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	703	235	F	L	Ttc/Ctc	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-3.82	deleterious	-5.03	high_impact	4.76	0.6	neutral	0.68	neutral	4.08	23.70	deleterious	0.37	0.55	0.33	neutral	0.84	disease	0.74	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.81	0.9	2.34	6.8	0.64	P	0.83	disease_causing	0.99	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8684	8684	C	T	MI.337	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	158	53	T	I	aCc/aTc	0.13	0	0.04	benign	0.01	neutral	0.4	neutral	4.53	neutral	1.16	neutral	-0.23	neutral_impact	-1.06	0.97	neutral	0.97	neutral	0.47	7.17	deleterious	0.28	0.65	0.29	neutral	0.23	neutral	0.43	neutral	0.41	neutral	2	0.59	neutral	0.7	deleterious	-6	neutral	0.11	neutral	1.14	medium_impact	0.19	medium_impact	-2.01	low_impact	0.65	0.9	11.95	17.19	0.32	N	0.06	polymorphism	1	0.01	rs201336180	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6606	6606	T	A	MI.3370	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	703	235	F	I	Ttc/Atc	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.02	deleterious	-5.03	high_impact	4.96	0.75	neutral	0.68	neutral	4.45	24.20	deleterious	0.2	0.55	0.72	disease	0.87	disease	0.79	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.66	0.9	2.34	6.8	0.7	P	0.88	disease_causing	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6606	6606	T	G	MI.3371	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	703	235	F	V	Ttc/Gtc	-1.95	0	0	probably_damaging	1	deleterious	0.02	neutral	2.45	deleterious	-4.93	deleterious	-5.87	high_impact	5.31	0.67	neutral	0.56	neutral	4.10	23.70	deleterious	0.26	0.55	0.77	disease	0.91	disease	0.77	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-0.75	medium_impact	3.8	high_impact	0.64	0.9	2.34	6.8	0.67	P	0.84	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6607	6607	T	G	MI.3372	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	704	235	F	C	tTc/tGc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.39	deleterious	-7.92	deleterious	-6.73	high_impact	5.31	0.72	neutral	0.56	neutral	4.13	23.80	deleterious	0.24	0.55	0.96	disease	0.89	disease	0.8	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.36	0.9	2.34	6.8	0.62	P	0.91	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6607	6607	T	A	MI.3373	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	704	235	F	Y	tTc/tAc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-4.79	deleterious	-2.52	high_impact	4.96	0.62	neutral	0.53	neutral	4.50	24.30	deleterious	0.22	0.55	0.71	disease	0.85	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.71	0.9	2.34	6.8	0.75	P	0.59	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6607	6607	T	C	MI.3374	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	704	235	F	S	tTc/tCc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-6.68	deleterious	-6.7	high_impact	5.31	0.85	neutral	0.67	neutral	4.36	24.10	deleterious	0.23	0.55	0.93	disease	0.86	disease	0.76	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.45	0.9	2.34	6.8	0.56	P	0.84	disease_causing	1	0.49	rs2853818	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6608	6608	C	G	MI.3375	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	705	235	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-3.82	deleterious	-5.03	high_impact	4.76	0.6	neutral	0.68	neutral	4.45	24.20	deleterious	0.37	0.55	0.33	neutral	0.84	disease	0.74	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.81	0.9	2.34	6.8	0.62	P	0.83	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6608	6608	C	A	MI.3376	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	705	235	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-3.82	deleterious	-5.03	high_impact	4.76	0.6	neutral	0.68	neutral	4.68	24.60	deleterious	0.37	0.55	0.33	neutral	0.84	disease	0.74	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.81	0.9	2.34	6.8	0.62	P	0.83	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6609	6609	T	C	MI.3377	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	706	236	W	R	Tga/Cga	-0.8	0.02	0	probably_damaging	1	deleterious	0	neutral	1.01	deleterious	-9.07	deleterious	-10.09	high_impact	4.61	0.63	neutral	0.04	damaging	3.58	23.20	deleterious	0.2	0.55	0.84	disease	0.94	disease	0.81	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.16	high_impact	0.25	0.9	2.14	6.63	0.46	N	0.98	disease_causing	0.97	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6609	6609	T	G	MI.3378	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	706	236	W	G	Tga/Gga	-0.8	0.02	0	probably_damaging	1	deleterious	0	neutral	1.02	deleterious	-8.48	deleterious	-9.37	high_impact	5.3	0.65	neutral	0.05	damaging	3.92	23.50	deleterious	0.18	0.55	0.93	disease	0.87	disease	0.79	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.26	0.9	2.14	6.63	0.53	P	0.89	disease_causing	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6610	6610	G	C	MI.3379	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	707	236	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	1.03	deleterious	-7.3	deleterious	-10.08	high_impact	5.3	0.64	neutral	0.05	damaging	4.12	23.80	deleterious	0.18	0.55	0.93	disease	0.91	disease	0.77	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.23	0.9	2.14	6.63	0.55	P	0.89	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8684	8684	C	A	MI.338	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	158	53	T	N	aCc/aAc	0.13	0	0.04	possibly_damaging	0.56	neutral	0.07	neutral	4.29	neutral	-2.97	neutral	-2.47	low_impact	1.77	0.81	neutral	0.55	neutral	3.32	22.90	deleterious	0.28	0.65	0.81	disease	0.44	neutral	0.65	disease	0.69	disease	4	0.93	neutral	0.26	neutral	-3	neutral	0.61	deleterious	-0.86	medium_impact	-0.34	medium_impact	0.42	medium_impact	0.74	0.9	11.95	17.19	0.33	N	0.64	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6610	6610	G	T	MI.3380	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	707	236	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	1.03	deleterious	-7.66	deleterious	-9.37	high_impact	4.96	0.69	neutral	0.03	damaging	4.31	24.00	deleterious	0.16	0.55	0.89	disease	0.89	disease	0.77	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.25	0.9	2.14	6.63	0.61	P	0.95	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6611	6611	A	T	MI.3381	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	708	236	W	C	tgA/tgT	9.15	1	0	probably_damaging	1	deleterious	0	neutral	1.01	deleterious	-9.9	deleterious	-9.39	high_impact	4.61	0.59	damaging	0.04	damaging	4.14	23.80	deleterious	0.21	0.55	0.97	disease	0.91	disease	0.82	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.16	high_impact	0.19	0.9	2.14	6.63	0.49	N	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6611	6611	A	C	MI.3382	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	708	236	W	C	tgA/tgC	9.15	1	0	probably_damaging	1	deleterious	0	neutral	1.01	deleterious	-9.9	deleterious	-9.39	high_impact	4.61	0.59	damaging	0.04	damaging	4.06	23.70	deleterious	0.21	0.55	0.97	disease	0.91	disease	0.82	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.16	high_impact	0.19	0.9	2.14	6.63	0.49	N	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6612	6612	T	C	MI.3383	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	709	237	F	L	Ttt/Ctt	5.68	1	0	probably_damaging	0.99	deleterious	0	neutral	2.72	neutral	-2	deleterious	-4.26	high_impact	4.61	0.81	neutral	0.06	damaging	4.16	23.80	deleterious	0.3	0.55	0.39	neutral	0.84	disease	0.62	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.64	low_impact	-1.48	low_impact	3.16	high_impact	0.78	0.9	2.73	6.76	0.51	P	0.83	disease_causing	1	0.18	.	.	.	.	.	.	COSM6716197	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6612	6612	T	A	MI.3384	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	709	237	F	I	Ttt/Att	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-1.82	deleterious	-4.26	high_impact	4.41	0.73	neutral	0.08	damaging	4.48	24.20	deleterious	0.19	0.55	0.32	neutral	0.87	disease	0.64	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.53	0.9	2.73	6.76	0.55	P	0.88	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6612	6612	T	G	MI.3385	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	709	237	F	V	Ttt/Gtt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-2.52	deleterious	-4.97	high_impact	4.61	0.72	neutral	0.07	damaging	4.18	23.80	deleterious	0.23	0.55	0.4	neutral	0.9	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.16	high_impact	0.55	0.9	2.73	6.76	0.55	P	0.84	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6613	6613	T	G	MI.3386	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	710	237	F	C	tTt/tGt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-5.1	deleterious	-5.7	high_impact	5.3	0.73	neutral	0.05	damaging	4.18	23.80	deleterious	0.22	0.55	0.89	disease	0.88	disease	0.71	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.26	0.9	2.73	6.76	0.68	P	0.91	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6613	6613	T	C	MI.3387	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	710	237	F	S	tTt/tCt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-3.21	deleterious	-5.66	high_impact	4.95	0.75	neutral	0.08	damaging	4.37	24.10	deleterious	0.23	0.55	0.84	disease	0.85	disease	0.7	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.34	0.9	2.73	6.76	0.71	P	0.84	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6613	6613	T	A	MI.3388	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	710	237	F	Y	tTt/tAt	5.68	1	0	probably_damaging	0.99	deleterious	0	neutral	2.71	neutral	-2.15	neutral	-2.13	high_impact	5.3	0.72	neutral	0.06	damaging	4.53	24.30	deleterious	0.21	0.55	0.75	disease	0.84	disease	0.67	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	3.8	high_impact	0.62	0.9	2.73	6.76	0.73	P	0.59	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6614	6614	T	A	MI.3389	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	711	237	F	L	ttT/ttA	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.72	neutral	-2	deleterious	-4.26	high_impact	4.61	0.81	neutral	0.06	damaging	4.42	24.20	deleterious	0.3	0.55	0.39	neutral	0.84	disease	0.62	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.64	low_impact	-1.48	low_impact	3.16	high_impact	0.78	0.9	2.73	6.76	0.52	P	0.83	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8684	8684	C	G	MI.339	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	158	53	T	S	aCc/aGc	0.13	0	0.04	benign	0.14	neutral	0.05	neutral	4.31	neutral	-1.75	neutral	-1.38	low_impact	0.88	0.84	neutral	0.65	neutral	0.46	7.14	deleterious	0.39	0.65	0.57	disease	0.23	neutral	0.43	neutral	0.54	disease	1	0.94	neutral	0.46	neutral	-6	neutral	0.26	neutral	-0.01	medium_impact	-0.43	medium_impact	-0.34	medium_impact	0.69	0.9	11.95	17.19	0.45	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6614	6614	T	G	MI.3390	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	711	237	F	L	ttT/ttG	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.72	neutral	-2	deleterious	-4.26	high_impact	4.61	0.81	neutral	0.06	damaging	4.22	23.90	deleterious	0.3	0.55	0.39	neutral	0.84	disease	0.62	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.64	low_impact	-1.48	low_impact	3.16	high_impact	0.78	0.9	2.73	6.76	0.49	N	0.83	disease_causing	1	0.18	rs28410416	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6615	6615	T	G	MI.3391	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	712	238	F	V	Ttc/Gtc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-2.4	deleterious	-4.94	high_impact	5.28	0.73	neutral	0.07	damaging	4.05	23.70	deleterious	0.27	0.55	0.87	disease	0.91	disease	0.72	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.49	0.9	1.75	7.02	0.68	P	0.84	disease_causing	0.99	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6615	6615	T	C	MI.3392	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	712	238	F	L	Ttc/Ctc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-1.64	deleterious	-4.22	high_impact	3.78	0.77	neutral	0.05	damaging	4.01	23.60	deleterious	0.29	0.55	0.75	disease	0.86	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.39	high_impact	0.76	0.9	1.75	7.02	0.3	N	0.83	disease_causing	0.99	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6615	6615	T	A	MI.3393	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	712	238	F	I	Ttc/Atc	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-2.52	deleterious	-4.23	high_impact	5.28	0.75	neutral	0.07	damaging	4.35	24.10	deleterious	0.22	0.55	0.87	disease	0.89	disease	0.71	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.60	0.9	1.75	7.02	0.69	P	0.88	disease_causing	0.99	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6616	6616	T	G	MI.3394	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	713	238	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-5.02	deleterious	-5.66	high_impact	5.28	0.75	neutral	0.06	damaging	4.06	23.70	deleterious	0.24	0.55	0.96	disease	0.88	disease	0.72	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.26	0.9	1.75	7.02	0.67	P	0.91	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6616	6616	T	C	MI.3395	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	713	238	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-3.49	deleterious	-5.64	high_impact	4.93	0.76	neutral	0.08	damaging	4.24	23.90	deleterious	0.24	0.55	0.89	disease	0.85	disease	0.7	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.33	0.9	1.75	7.02	0.71	P	0.84	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6616	6616	T	A	MI.3396	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	713	238	F	Y	tTc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.6	neutral	-2.36	neutral	-2.12	high_impact	3.58	0.74	neutral	0.07	damaging	4.17	23.80	deleterious	0.22	0.55	0.27	neutral	0.86	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.21	high_impact	0.65	0.9	1.75	7.02	0.51	N	0.59	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6617	6617	C	G	MI.3397	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	714	238	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-1.64	deleterious	-4.22	high_impact	3.78	0.77	neutral	0.05	damaging	4.36	24.10	deleterious	0.29	0.55	0.75	disease	0.86	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.39	high_impact	0.76	0.9	1.75	7.02	0.52	P	0.83	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6617	6617	C	A	MI.3398	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	714	238	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-1.64	deleterious	-4.22	high_impact	3.78	0.77	neutral	0.05	damaging	4.63	24.50	deleterious	0.29	0.55	0.75	disease	0.86	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.39	high_impact	0.76	0.9	1.75	7.02	0.52	P	0.83	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6618	6618	G	C	MI.3399	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	715	239	G	R	Ggt/Cgt	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.29	deleterious	-5.15	deleterious	-5.63	high_impact	5.3	0.42	damaging	0.03	damaging	3.97	23.60	deleterious	0.14	0.55	0.89	disease	0.93	disease	0.79	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.72	0.9	2.34	6.81	0.59	P	0.95	polymorphism	0.54	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8540	8540	T	G	MI.34	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	14	5	L	R	cTg/cGg	-1.95	0	0	probably_damaging	0.99	deleterious	0	neutral	4.11	deleterious	-3.77	deleterious	-4.69	medium_impact	2.93	0.76	neutral	0.36	neutral	4.03	23.60	deleterious	0.23	0.65	0.86	disease	0.77	disease	0.79	disease	0.85	disease	7	1	deleterious	0.01	neutral	5	deleterious	0.88	deleterious	-2.65	low_impact	-1.4	low_impact	1.41	medium_impact	0.66	0.9	50.44	8.42	0.31	N	0.99	polymorphism	0.52	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8686	8686	T	C	MI.340	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	160	54	S	P	Tca/Cca	-5.89	0	0	benign	0.33	neutral	0.2	neutral	4.34	neutral	-2.16	neutral	-2.16	medium_impact	2.23	0.78	neutral	0.36	neutral	2.14	17.11	deleterious	0.23	0.65	0.75	disease	0.78	disease	0.52	disease	0.72	disease	4	0.76	neutral	0.44	neutral	-3	neutral	0.59	deleterious	-0.46	medium_impact	-0.05	medium_impact	0.81	medium_impact	0.49	0.9	28.32	24.19	0.25	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6618	6618	G	T	MI.3400	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	715	239	G	C	Ggt/Tgt	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.28	deleterious	-6.83	deleterious	-6.34	high_impact	5.3	0.37	damaging	0.03	damaging	4.21	23.90	deleterious	0.13	0.55	0.89	disease	0.92	disease	0.69	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.56	0.9	2.34	6.81	0.49	P	0.98	disease_causing	0.63	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6618	6618	G	A	MI.3401	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	715	239	G	S	Ggt/Agt	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.37	deleterious	-3.23	deleterious	-4.2	high_impact	3.98	0.45	damaging	0.04	damaging	4.20	23.90	deleterious	0.2	0.55	0.31	neutral	0.84	disease	0.66	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.58	high_impact	0.68	0.9	2.34	6.81	0.37	N	0.73	polymorphism	0.71	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6619	6619	G	T	MI.3402	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	716	239	G	V	gGt/gTt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.8	deleterious	-6.32	high_impact	5.3	0.47	damaging	0.04	damaging	3.80	23.40	deleterious	0.13	0.55	0.82	disease	0.92	disease	0.71	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.48	0.9	2.34	6.81	0.62	P	0.93	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6619	6619	G	C	MI.3403	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	716	239	G	A	gGt/gCt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.38	deleterious	-3.56	deleterious	-4.2	high_impact	5.3	0.56	damaging	0.05	damaging	3.17	22.70	deleterious	0.23	0.55	0.59	disease	0.8	disease	0.6	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.73	0.9	2.34	6.81	0.67	P	0.64	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6619	6619	G	A	MI.3404	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	716	239	G	D	gGt/gAt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.28	deleterious	-5.18	deleterious	-4.92	high_impact	4.95	0.29	damaging	0.03	damaging	3.76	23.30	deleterious	0.13	0.55	0.84	disease	0.91	disease	0.73	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.41	0.9	2.34	6.81	0.8	P	0.97	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6621	6621	C	A	MI.3405	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	718	240	H	N	Cac/Aac	-20	0	0	probably_damaging	1	deleterious	0	neutral	-1.22	deleterious	-12.3	deleterious	-4.88	high_impact	5.3	0.51	damaging	0.02	damaging	3.90	23.50	deleterious	0.34	0.55	0.8	disease	0.87	disease	0.75	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.44	0.9	3.31	6.76	0.43	N	0.86	polymorphism	0.68	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6621	6621	C	G	MI.3406	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	718	240	H	D	Cac/Gac	-20	0	0	probably_damaging	1	deleterious	0	neutral	-1.22	deleterious	-11.87	deleterious	-6.28	high_impact	5.3	0.48	damaging	0.02	damaging	3.85	23.40	deleterious	0.19	0.55	0.76	disease	0.86	disease	0.82	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.43	0.9	3.31	6.76	0.41	N	0.97	disease_causing	0.61	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6621	6621	C	T	MI.3407	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	718	240	H	Y	Cac/Tac	-20	0	0	probably_damaging	0.99	deleterious	0	neutral	-1.21	deleterious	-11.5	deleterious	-4.18	high_impact	4.75	0.52	damaging	0.02	damaging	3.78	23.40	deleterious	0.29	0.55	0.82	disease	0.9	disease	0.77	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.64	low_impact	-1.48	low_impact	3.29	high_impact	0.46	0.9	3.31	6.76	0.45	N	0.72	polymorphism	0.63	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6622	6622	A	T	MI.3408	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	719	240	H	L	cAc/cTc	4.52	1	0	probably_damaging	0.99	deleterious	0	neutral	-1.22	deleterious	-12.15	deleterious	-7.67	high_impact	5.3	0.6	damaging	0.03	damaging	3.82	23.40	deleterious	0.19	0.55	0.85	disease	0.93	disease	0.75	disease	0.82	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.64	low_impact	-1.48	low_impact	3.8	high_impact	0.38	0.9	3.31	6.76	0.49	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6622	6622	A	G	MI.3409	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	719	240	H	R	cAc/cGc	4.52	1	0	probably_damaging	0.99	deleterious	0	neutral	-1.22	deleterious	-11.87	deleterious	-5.58	high_impact	5.3	0.54	damaging	0.02	damaging	3.03	22.30	deleterious	0.31	0.55	0.73	disease	0.9	disease	0.8	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.64	low_impact	-1.48	low_impact	3.8	high_impact	0.49	0.9	3.31	6.76	0.5	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8686	8686	T	G	MI.341	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	160	54	S	A	Tca/Gca	-5.89	0	0	benign	0.03	neutral	0.55	neutral	4.41	neutral	0.26	neutral	-0.64	neutral_impact	0.46	0.92	neutral	0.85	neutral	0.39	6.57	deleterious	0.41	0.65	0.37	neutral	0.2	neutral	0.22	neutral	0.37	neutral	3	0.41	neutral	0.76	deleterious	-6	neutral	0.16	neutral	0.68	medium_impact	0.34	medium_impact	-0.7	medium_impact	0.53	0.9	28.32	24.19	0.34	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6622	6622	A	C	MI.3410	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	719	240	H	P	cAc/cCc	4.52	1	0	probably_damaging	1	deleterious	0	neutral	-1.22	deleterious	-12.5	deleterious	-6.99	high_impact	4.25	0.39	damaging	0.04	damaging	3.22	22.70	deleterious	0.18	0.55	0.9	disease	0.89	disease	0.75	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.35	0.9	3.31	6.76	0.54	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6623	6623	C	G	MI.3411	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	720	240	H	Q	caC/caG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	-1.22	deleterious	-12.49	deleterious	-5.58	high_impact	4.75	0.57	damaging	0.02	damaging	3.61	23.20	deleterious	0.3	0.55	0.67	disease	0.82	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.57	0.9	3.31	6.76	0.52	P	0.83	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6623	6623	C	A	MI.3412	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	720	240	H	Q	caC/caA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	-1.22	deleterious	-12.49	deleterious	-5.58	high_impact	4.75	0.57	damaging	0.02	damaging	3.91	23.50	deleterious	0.3	0.55	0.67	disease	0.82	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.57	0.9	3.31	6.76	0.52	P	0.83	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6624	6624	C	G	MI.3413	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	721	241	P	A	Cct/Gct	-0.33	0.35	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.51	deleterious	-5.54	high_impact	5.31	0.7	neutral	0.13	damaging	3.07	22.40	deleterious	0.19	0.55	0.69	disease	0.79	disease	0.68	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.70	0.9	4.09	7.83	0.61	P	0.76	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6624	6624	C	A	MI.3414	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	721	241	P	T	Cct/Act	-0.33	0.35	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.6	deleterious	-5.54	high_impact	5.31	0.66	neutral	0.09	damaging	3.86	23.50	deleterious	0.25	0.55	0.37	neutral	0.87	disease	0.57	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.68	0.9	4.09	7.83	0.53	P	0.80	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6624	6624	C	T	MI.3415	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	721	241	P	S	Cct/Tct	-0.33	0.35	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-3.84	deleterious	-5.54	high_impact	5.31	0.74	neutral	0.12	damaging	3.85	23.40	deleterious	0.32	0.55	0.73	disease	0.85	disease	0.66	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.36	0.9	4.09	7.83	0.63	P	0.85	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6625	6625	C	T	MI.3416	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	722	241	P	L	cCt/cTt	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-4.96	deleterious	-6.92	high_impact	5.31	0.53	damaging	0.11	damaging	4.32	24.00	deleterious	0.24	0.55	0.9	disease	0.91	disease	0.63	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.80	0.9	4.09	7.83	0.63	P	0.87	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6625	6625	C	A	MI.3417	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	722	241	P	H	cCt/cAt	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-6.29	deleterious	-6.25	high_impact	4.96	0.66	neutral	0.07	damaging	3.98	23.60	deleterious	0.22	0.55	0.95	disease	0.91	disease	0.75	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.62	0.9	4.09	7.83	0.63	P	0.81	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6625	6625	C	G	MI.3418	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	722	241	P	R	cCt/cGt	5.45	1	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.87	deleterious	-6.25	high_impact	5.31	0.65	neutral	0.08	damaging	3.63	23.20	deleterious	0.17	0.55	0.91	disease	0.93	disease	0.78	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.64	0.9	4.09	7.83	0.66	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6627	6627	G	A	MI.3419	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	724	242	E	K	Gaa/Aaa	-14.22	0	0	benign	0.04	deleterious	0	neutral	2.54	neutral	-2.49	deleterious	-2.75	high_impact	4.39	0.43	damaging	0.14	damaging	4.50	24.30	deleterious	0.31	0.55	0.28	neutral	0.9	disease	0.66	disease	0.67	disease	3	1	deleterious	0.48	deleterious	2	deleterious	0.30	neutral	0.54	medium_impact	-1.48	low_impact	2.95	high_impact	0.65	0.9	2.92	7.1	0.46	N	0.72	polymorphism	0.91	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8686	8686	T	A	MI.342	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	160	54	S	T	Tca/Aca	-5.89	0	0	benign	0.13	neutral	0.52	neutral	4.42	neutral	-0.47	neutral	1.15	neutral_impact	-0.96	0.86	neutral	0.94	neutral	-0.91	0.02	neutral	0.32	0.65	0.46	neutral	0.07	neutral	0.13	neutral	0.25	neutral	5	0.39	neutral	0.7	deleterious	-6	neutral	0.18	neutral	0.03	medium_impact	0.31	medium_impact	-1.92	low_impact	0.65	0.9	28.32	24.19	0.43	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6627	6627	G	C	MI.3420	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	724	242	E	Q	Gaa/Caa	-14.22	0	0	possibly_damaging	0.47	deleterious	0	neutral	2.52	neutral	-2.97	neutral	-2.07	high_impact	4.59	0.57	damaging	0.13	damaging	3.40	23.00	deleterious	0.38	0.55	0.52	disease	0.8	disease	0.6	disease	0.67	disease	3	1	deleterious	0.27	neutral	5	deleterious	0.60	deleterious	-0.71	medium_impact	-1.48	low_impact	3.14	high_impact	0.85	0.9	2.92	7.1	0.4	N	0.66	polymorphism	0.98	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6628	6628	A	G	MI.3421	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	725	242	E	G	gAa/gGa	6.14	1	0	possibly_damaging	0.66	deleterious	0	neutral	2.51	deleterious	-3.36	deleterious	-4.83	high_impact	5.29	0.49	damaging	0.16	damaging	4.34	24.00	deleterious	0.27	0.55	0.66	disease	0.81	disease	0.69	disease	0.7	disease	4	1	deleterious	0.17	neutral	5	deleterious	0.72	deleterious	-1.03	low_impact	-1.48	low_impact	3.79	high_impact	0.59	0.9	2.92	7.1	0.68	P	0.67	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6628	6628	A	C	MI.3422	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	725	242	E	A	gAa/gCa	6.14	1	0	possibly_damaging	0.55	deleterious	0	neutral	2.63	neutral	-1.15	deleterious	-4.12	high_impact	3.98	0.63	neutral	0.16	damaging	3.77	23.40	deleterious	0.23	0.55	0.33	neutral	0.82	disease	0.65	disease	0.7	disease	4	1	deleterious	0.23	neutral	5	deleterious	0.53	deleterious	-0.84	medium_impact	-1.48	low_impact	2.58	high_impact	0.72	0.9	2.92	7.1	0.51	P	0.71	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6628	6628	A	T	MI.3423	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	725	242	E	V	gAa/gTa	6.14	1	0	possibly_damaging	0.75	deleterious	0	neutral	2.6	neutral	-1.54	deleterious	-4.84	high_impact	5.29	0.53	damaging	0.13	damaging	4.28	24.00	deleterious	0.22	0.55	0.4	neutral	0.93	disease	0.68	disease	0.74	disease	5	1	deleterious	0.13	neutral	5	deleterious	0.67	deleterious	-1.21	low_impact	-1.48	low_impact	3.79	high_impact	0.73	0.9	2.92	7.1	0.65	P	0.67	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6629	6629	A	T	MI.3424	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	726	242	E	D	gaA/gaT	8.69	1	0	benign	0.16	deleterious	0	neutral	2.51	deleterious	-3.37	neutral	-2.07	high_impact	4.95	0.58	damaging	0.13	damaging	3.91	23.50	deleterious	0.39	0.55	0.55	disease	0.8	disease	0.57	disease	0.67	disease	3	1	deleterious	0.42	neutral	2	deleterious	0.37	neutral	-0.08	medium_impact	-1.48	low_impact	3.47	high_impact	0.86	0.9	2.92	7.1	0.63	P	0.69	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6629	6629	A	C	MI.3425	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	726	242	E	D	gaA/gaC	8.69	1	0	benign	0.16	deleterious	0	neutral	2.51	deleterious	-3.37	neutral	-2.07	high_impact	4.95	0.58	damaging	0.13	damaging	3.75	23.30	deleterious	0.39	0.55	0.55	disease	0.8	disease	0.57	disease	0.67	disease	3	1	deleterious	0.42	neutral	2	deleterious	0.37	neutral	-0.08	medium_impact	-1.48	low_impact	3.47	high_impact	0.86	0.9	2.92	7.1	0.63	P	0.69	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6630	6630	G	C	MI.3426	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	727	243	V	L	Gtt/Ctt	2.67	1	0	probably_damaging	0.95	deleterious	0	neutral	1.88	deleterious	-4.27	neutral	-2.05	high_impact	5.31	0.64	neutral	0.14	damaging	3.53	23.10	deleterious	0.35	0.55	0.7	disease	0.81	disease	0.55	disease	0.68	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.79	deleterious	-1.96	low_impact	-1.48	low_impact	3.8	high_impact	0.76	0.9	1.75	6.65	0.68	P	0.55	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6630	6630	G	A	MI.3427	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	727	243	V	I	Gtt/Att	2.67	1	0	probably_damaging	0.95	deleterious	0	neutral	1.88	deleterious	-3.52	neutral	-0.68	high_impact	4.96	0.7	neutral	0.16	damaging	3.65	23.20	deleterious	0.43	0.55	0.57	disease	0.69	disease	0.56	disease	0.64	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.74	deleterious	-1.96	low_impact	-1.48	low_impact	3.48	high_impact	0.86	0.9	1.75	6.65	0.68	P	0.24	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6630	6630	G	T	MI.3428	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	727	243	V	F	Gtt/Ttt	2.67	1	0	probably_damaging	1	deleterious	0	neutral	1.78	deleterious	-6.04	deleterious	-3.41	high_impact	4.96	0.62	neutral	0.11	damaging	3.86	23.50	deleterious	0.15	0.55	0.88	disease	0.92	disease	0.6	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.66	0.9	1.75	6.65	0.66	P	0.86	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6631	6631	T	G	MI.3429	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	728	243	V	G	gTt/gGt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	1.78	deleterious	-6.77	deleterious	-4.8	high_impact	4.96	0.65	neutral	0.17	damaging	3.87	23.50	deleterious	0.13	0.55	0.85	disease	0.79	disease	0.62	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.56	0.9	1.75	6.65	0.66	P	0.71	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8687	8687	C	T	MI.343	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	161	54	S	L	tCa/tTa	-0.33	0	0	benign	0	neutral	0.68	neutral	4.43	neutral	-1.43	neutral	-0.24	neutral_impact	0.61	0.98	neutral	0.89	neutral	0.82	9.59	deleterious	0.3	0.65	0.45	neutral	0.42	neutral	0.25	neutral	0.47	neutral	1	0.31	neutral	0.84	deleterious	-6	neutral	0.18	neutral	2.09	high_impact	0.48	medium_impact	-0.58	medium_impact	0.78	0.9	28.32	24.19	0.31	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6631	6631	T	C	MI.3430	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	728	243	V	A	gTt/gCt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	1.85	deleterious	-4.96	deleterious	-2.72	high_impact	5.31	0.54	damaging	0.18	damaging	3.63	23.20	deleterious	0.31	0.55	0.63	disease	0.72	disease	0.58	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.52	0.9	1.75	6.65	0.7	P	0.47	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6631	6631	T	A	MI.3431	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	728	243	V	D	gTt/gAt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	1.77	deleterious	-7.92	deleterious	-4.8	high_impact	5.31	0.71	neutral	0.13	damaging	4.75	24.70	deleterious	0.1	0.55	0.94	disease	0.88	disease	0.66	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.49	0.9	1.75	6.65	0.67	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6633	6633	T	C	MI.3432	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	730	244	Y	H	Tat/Cat	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.29	deleterious	-6.06	deleterious	-3.41	high_impact	4.61	0.58	damaging	0.05	damaging	3.55	23.10	deleterious	0.25	0.55	0.9	disease	0.83	disease	0.74	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.16	high_impact	0.54	0.9	2.53	6.64	0.36	N	0.61	polymorphism	0.79	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6633	6633	T	G	MI.3433	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	730	244	Y	D	Tat/Gat	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.33	deleterious	-6.45	deleterious	-6.83	high_impact	5.3	0.47	damaging	0.05	damaging	3.95	23.60	deleterious	0.14	0.55	0.94	disease	0.86	disease	0.79	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.32	0.9	2.53	6.64	0.48	P	0.98	disease_causing	0.69	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6633	6633	T	A	MI.3434	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	730	244	Y	N	Tat/Aat	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-5.62	deleterious	-6.14	high_impact	4.96	0.57	damaging	0.06	damaging	4.01	23.60	deleterious	0.22	0.55	0.93	disease	0.86	disease	0.67	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.35	0.9	2.53	6.64	0.53	P	0.94	disease_causing	0.75	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6634	6634	A	G	MI.3435	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	731	244	Y	C	tAt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.27	deleterious	-7.85	deleterious	-6.16	high_impact	5.3	0.53	damaging	0.05	damaging	3.57	23.20	deleterious	0.24	0.55	0.97	disease	0.87	disease	0.74	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.28	0.9	2.53	6.64	0.59	P	0.89	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6634	6634	A	T	MI.3436	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	731	244	Y	F	tAt/tTt	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.28	deleterious	-5.02	deleterious	-2.73	high_impact	5.3	0.56	damaging	0.06	damaging	3.40	23.00	deleterious	0.22	0.55	0.7	disease	0.82	disease	0.65	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.8	high_impact	0.62	0.9	2.53	6.64	0.71	P	0.50	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6634	6634	A	C	MI.3437	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	731	244	Y	S	tAt/tCt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-5.73	deleterious	-6.13	high_impact	5.3	0.58	damaging	0.06	damaging	3.74	23.30	deleterious	0.2	0.55	0.89	disease	0.82	disease	0.7	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.43	0.9	2.53	6.64	0.66	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6636	6636	A	C	MI.3438	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	733	245	I	L	Att/Ctt	-4.73	0	0	probably_damaging	0.97	deleterious	0	neutral	2.63	neutral	-2.24	neutral	-1.37	high_impact	4.54	0.68	neutral	0.06	damaging	1.81	15.02	deleterious	0.26	0.55	0.56	disease	0.73	disease	0.52	disease	0.57	disease	1	1	deleterious	0.02	neutral	6	deleterious	0.71	deleterious	-2.18	low_impact	-1.48	low_impact	3.09	high_impact	0.67	0.9	2.53	6.9	0.38	N	0.61	disease_causing	0.97	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6636	6636	A	G	MI.3439	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	733	245	I	V	Att/Gtt	-4.73	0	0	probably_damaging	0.92	neutral	0.26	neutral	2.6	neutral	-2.1	neutral	-0.69	medium_impact	3.02	0.64	neutral	0.09	damaging	1.01	10.69	neutral	0.32	0.55	0.35	neutral	0.57	disease	0.42	neutral	0.45	neutral	1	0.93	neutral	0.17	neutral	1	deleterious	0.62	deleterious	-1.76	low_impact	-0.06	medium_impact	1.69	medium_impact	0.68	0.9	2.53	6.9	0.35	N	0.23	disease_causing	0.94	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8687	8687	C	G	MI.344	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	161	54	S	W	tCa/tGa	-0.33	0	0	possibly_damaging	0.74	neutral	0.18	neutral	4.3	deleterious	-4.62	deleterious	-2.68	low_impact	1.34	0.86	neutral	0.42	neutral	3.98	23.60	deleterious	0.2	0.65	0.94	disease	0.73	disease	0.54	disease	0.82	disease	6	0.87	neutral	0.22	neutral	-3	neutral	0.73	deleterious	-1.19	low_impact	-0.08	medium_impact	0.05	medium_impact	0.51	0.9	28.32	24.19	0.31	N	0.57	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6636	6636	A	T	MI.3440	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	733	245	I	F	Att/Ttt	-4.73	0	0	probably_damaging	1	deleterious	0	neutral	2.49	neutral	-1.76	deleterious	-2.73	high_impact	4.89	0.63	neutral	0.05	damaging	3.35	22.90	deleterious	0.17	0.55	0.61	disease	0.84	disease	0.64	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.76	0.9	2.53	6.9	0.63	P	0.85	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6637	6637	T	G	MI.3441	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	734	245	I	S	aTt/aGt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-3.97	deleterious	-4.1	high_impact	5.24	0.66	neutral	0.09	damaging	4.14	23.80	deleterious	0.15	0.55	0.91	disease	0.85	disease	0.61	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.48	0.9	2.53	6.9	0.7	P	0.62	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6637	6637	T	C	MI.3442	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	734	245	I	T	aTt/aCt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-3.59	deleterious	-3.42	high_impact	4.34	0.64	neutral	0.07	damaging	3.08	22.50	deleterious	0.2	0.55	0.83	disease	0.8	disease	0.56	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.91	high_impact	0.55	0.9	2.53	6.9	0.43	N	0.76	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6637	6637	T	A	MI.3443	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	734	245	I	N	aTt/aAt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-5.2	deleterious	-4.8	high_impact	5.24	0.62	neutral	0.07	damaging	4.36	24.10	deleterious	0.14	0.55	0.95	disease	0.87	disease	0.64	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.48	0.9	2.53	6.9	0.69	P	0.94	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6638	6638	T	A	MI.3444	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	735	245	I	M	atT/atA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-3.53	neutral	-2.05	high_impact	4.89	0.67	neutral	0.07	damaging	3.68	23.30	deleterious	0.21	0.55	0.81	disease	0.68	disease	0.55	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.71	0.9	2.53	6.9	0.71	P	0.76	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6638	6638	T	G	MI.3445	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	735	245	I	M	atT/atG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-3.53	neutral	-2.05	high_impact	4.89	0.67	neutral	0.07	damaging	3.32	22.90	deleterious	0.21	0.55	0.81	disease	0.68	disease	0.55	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.71	0.9	2.53	6.9	0.69	P	0.76	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6639	6639	C	T	MI.3446	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	736	246	L	F	Ctt/Ttt	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-2.91	deleterious	-2.75	high_impact	4.42	0.52	damaging	0.03	damaging	3.96	23.60	deleterious	0.33	0.55	0.56	disease	0.81	disease	0.57	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.71	0.9	2.14	6.71	0.37	N	0.87	disease_causing	0.6	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6639	6639	C	G	MI.3447	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	736	246	L	V	Ctt/Gtt	-1.03	0	0	probably_damaging	0.99	deleterious	0	neutral	2.78	neutral	-0.44	neutral	-2.06	high_impact	3.64	0.52	damaging	0.04	damaging	3.43	23.00	deleterious	0.32	0.55	0.26	neutral	0.76	disease	0.56	disease	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.26	high_impact	0.77	0.9	2.14	6.71	0.3	N	0.66	polymorphism	0.77	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6639	6639	C	A	MI.3448	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	736	246	L	I	Ctt/Att	-1.03	0	0	probably_damaging	1	deleterious	0.04	neutral	2.69	neutral	-1.38	neutral	-1.38	medium_impact	3.27	0.55	damaging	0.04	damaging	4.13	23.80	deleterious	0.27	0.55	0.35	neutral	0.76	disease	0.41	neutral	0.54	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-0.58	medium_impact	1.92	medium_impact	0.74	0.9	2.14	6.71	0.31	N	0.54	polymorphism	0.86	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6640	6640	T	G	MI.3449	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	737	246	L	R	cTt/cGt	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.98	deleterious	-4.13	high_impact	5.23	0.53	damaging	0.03	damaging	4.14	23.80	deleterious	0.13	0.55	0.66	disease	0.93	disease	0.75	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.73	high_impact	0.39	0.9	2.14	6.71	0.64	P	0.90	polymorphism	0.96	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8689	8689	A	G	MI.345	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	163	55	K	E	Aaa/Gaa	-3.8	0	0	probably_damaging	0.99	neutral	0.23	neutral	4.36	neutral	-0.38	deleterious	-2.9	medium_impact	2.21	0.88	neutral	0.47	neutral	3.88	23.50	deleterious	0.5	0.65	0.29	neutral	0.77	disease	0.5	neutral	0.53	disease	1	0.99	deleterious	0.12	neutral	1	deleterious	0.74	deleterious	-2.65	low_impact	-0.01	medium_impact	0.8	medium_impact	0.65	0.9	49.12	8.68	0.33	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6640	6640	T	A	MI.3450	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	737	246	L	H	cTt/cAt	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.52	deleterious	-4.81	high_impact	5.23	0.56	damaging	0.02	damaging	4.00	23.60	deleterious	0.13	0.55	0.74	disease	0.86	disease	0.72	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.73	high_impact	0.46	0.9	2.14	6.71	0.64	P	0.83	polymorphism	0.98	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6640	6640	T	C	MI.3451	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	737	246	L	P	cTt/cCt	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.38	deleterious	-4.83	high_impact	4.68	0.41	damaging	0.05	damaging	3.79	23.40	deleterious	0.15	0.55	0.68	disease	0.84	disease	0.64	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.58	0.9	2.14	6.71	0.51	P	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6642	6642	A	G	MI.3452	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	739	247	I	V	Atc/Gtc	-20	0	0	probably_damaging	0.95	deleterious	0.02	neutral	2.69	neutral	-0.65	neutral	-0.66	medium_impact	3.35	0.59	damaging	0.12	damaging	3.07	22.40	deleterious	0.5	0.55	0.35	neutral	0.57	disease	0.59	disease	0.55	disease	1	1	deleterious	0.04	neutral	5	deleterious	0.67	deleterious	-1.96	low_impact	-0.75	medium_impact	1.99	medium_impact	0.77	0.9	7.02	8.29	0.35	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6642	6642	A	T	MI.3453	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	739	247	I	F	Atc/Ttc	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-1.17	deleterious	-2.75	high_impact	4.55	0.59	damaging	0.11	damaging	3.81	23.40	deleterious	0.26	0.55	0.5	disease	0.83	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.85	0.9	7.02	8.29	0.41	N	0.85	polymorphism	0.51	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6642	6642	A	C	MI.3454	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	739	247	I	L	Atc/Ctc	-20	0	0	probably_damaging	0.98	deleterious	0	neutral	2.71	neutral	-0.53	neutral	-1.38	high_impact	5.24	0.62	neutral	0.09	damaging	3.80	23.40	deleterious	0.29	0.55	0.31	neutral	0.7	disease	0.63	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.70	deleterious	-2.35	low_impact	-1.48	low_impact	3.74	high_impact	0.74	0.9	7.02	8.29	0.6	P	0.61	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6643	6643	T	A	MI.3455	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	740	247	I	N	aTc/aAc	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.43	deleterious	-4.83	high_impact	4.89	0.55	damaging	0.1	damaging	4.36	24.10	deleterious	0.19	0.55	0.77	disease	0.84	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.70	0.9	7.02	8.29	0.7	P	0.94	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6643	6643	T	G	MI.3456	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	740	247	I	S	aTc/aGc	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.18	deleterious	-4.12	high_impact	5.24	0.61	neutral	0.13	damaging	4.24	23.90	deleterious	0.2	0.55	0.62	disease	0.85	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.65	0.9	7.02	8.29	0.73	P	0.62	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6643	6643	T	C	MI.3457	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	740	247	I	T	aTc/aCc	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-2.8	deleterious	-3.41	high_impact	5.24	0.6	neutral	0.09	damaging	3.40	23.00	deleterious	0.36	0.55	0.57	disease	0.8	disease	0.67	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.75	0.9	7.02	8.29	0.7	P	0.76	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6644	6644	C	G	MI.3458	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	741	247	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-2.82	neutral	-2.05	high_impact	4.43	0.64	neutral	0.08	damaging	3.42	23.00	deleterious	0.3	0.55	0.55	disease	0.68	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.99	high_impact	0.91	0.95	7.02	8.29	0.48	N	0.76	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6644	6644	C	A	MI.3459	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	741	247	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-2.82	neutral	-2.05	high_impact	4.43	0.64	neutral	0.08	damaging	3.89	23.50	deleterious	0.3	0.55	0.55	disease	0.68	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.99	high_impact	0.91	0.95	7.02	8.29	0.48	N	0.76	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8689	8689	A	C	MI.346	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	163	55	K	Q	Aaa/Caa	-3.8	0	0	probably_damaging	1	neutral	0.36	neutral	4.3	neutral	-1.14	deleterious	-2.62	low_impact	1.18	0.85	neutral	0.64	neutral	1.86	15.32	deleterious	0.55	0.65	0.59	disease	0.48	neutral	0.33	neutral	0.57	disease	1	1	deleterious	0.18	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.15	medium_impact	-0.09	medium_impact	0.75	0.9	49.12	8.68	0.3	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6645	6645	C	G	MI.3460	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	742	248	L	V	Cta/Gta	-4.5	0	0	probably_damaging	0.98	deleterious	0	neutral	2.4	deleterious	-3.15	neutral	-1.95	high_impact	4.53	0.53	damaging	0.06	damaging	3.39	23.00	deleterious	0.46	0.55	0.59	disease	0.77	disease	0.58	disease	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.35	low_impact	-1.48	low_impact	3.08	high_impact	0.72	0.9	7.8	8.21	0.38	N	0.66	disease_causing	0.72	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6645	6645	C	A	MI.3461	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	742	248	L	M	Cta/Ata	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.35	deleterious	-3.48	neutral	-1.36	high_impact	4.12	0.57	damaging	0.07	damaging	3.71	23.30	deleterious	0.32	0.55	0.66	disease	0.65	disease	0.56	disease	0.56	disease	1	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.76	0.9	7.8	8.21	0.31	N	0.59	disease_causing	0.67	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6646	6646	T	C	MI.3462	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	743	248	L	P	cTa/cCa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.31	deleterious	-6.38	deleterious	-4.82	high_impact	4.53	0.41	damaging	0.05	damaging	3.90	23.50	deleterious	0.16	0.55	0.93	disease	0.85	disease	0.66	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.08	high_impact	0.58	0.9	7.8	8.21	0.45	N	0.83	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6646	6646	T	G	MI.3463	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	743	248	L	R	cTa/cGa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-5.81	deleterious	-4.15	high_impact	5.22	0.52	damaging	0.04	damaging	4.19	23.80	deleterious	0.16	0.55	0.91	disease	0.92	disease	0.78	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.44	0.9	7.8	8.21	0.63	P	0.90	disease_causing	0.81	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6646	6646	T	A	MI.3464	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	743	248	L	Q	cTa/cAa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-5.95	deleterious	-4.15	high_impact	5.22	0.56	damaging	0.05	damaging	4.06	23.70	deleterious	0.18	0.55	0.91	disease	0.84	disease	0.67	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.68	0.9	7.8	8.21	0.61	P	0.82	disease_causing	0.77	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6648	6648	C	G	MI.3465	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	745	249	P	A	Cca/Gca	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.56	deleterious	-5.59	high_impact	4.61	0.69	neutral	0.09	damaging	3.05	22.40	deleterious	0.22	0.55	0.81	disease	0.78	disease	0.72	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.16	high_impact	0.61	0.9	6.43	8.06	0.38	N	0.76	polymorphism	0.89	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6648	6648	C	A	MI.3466	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	745	249	P	T	Cca/Aca	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-5.3	deleterious	-5.59	high_impact	4.75	0.68	neutral	0.06	damaging	3.62	23.20	deleterious	0.25	0.55	0.87	disease	0.88	disease	0.67	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.66	0.9	6.43	8.06	0.53	N	0.80	polymorphism	0.85	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6648	6648	C	T	MI.3467	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	745	249	P	S	Cca/Tca	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-5.02	deleterious	-5.58	high_impact	4.5	0.68	neutral	0.06	damaging	3.85	23.40	deleterious	0.31	0.55	0.84	disease	0.87	disease	0.71	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.31	0.9	6.43	8.06	0.36	N	0.85	polymorphism	0.84	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6649	6649	C	T	MI.3468	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	746	249	P	L	cCa/cTa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-6.93	deleterious	-7	high_impact	5.3	0.7	neutral	0.03	damaging	4.32	24.00	deleterious	0.26	0.55	0.86	disease	0.91	disease	0.7	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.65	0.9	6.43	8.06	0.65	P	0.87	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6649	6649	C	G	MI.3469	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	746	249	P	R	cCa/cGa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-6.93	deleterious	-6.3	high_impact	5.3	0.66	neutral	0.05	damaging	3.53	23.10	deleterious	0.16	0.55	0.92	disease	0.93	disease	0.82	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.62	0.9	6.43	8.06	0.63	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8690	8690	A	C	MI.347	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	164	55	K	T	aAa/aCa	2.44	0.98	0	probably_damaging	0.99	neutral	0.22	neutral	4.31	neutral	-0.97	deleterious	-4.68	medium_impact	2.09	0.84	neutral	0.52	neutral	3.47	23.00	deleterious	0.32	0.65	0.67	disease	0.72	disease	0.45	neutral	0.5	neutral	0	0.99	deleterious	0.12	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	-0.02	medium_impact	0.69	medium_impact	0.44	0.9	49.12	8.68	0.44	N	0.81	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6649	6649	C	A	MI.3470	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	746	249	P	Q	cCa/cAa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-6.81	deleterious	-5.6	high_impact	5.3	0.68	neutral	0.05	damaging	4.10	23.70	deleterious	0.18	0.55	0.94	disease	0.88	disease	0.75	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.55	0.9	6.43	8.06	0.65	P	0.82	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6651	6651	G	T	MI.3471	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	748	250	G	C	Ggc/Tgc	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.07	deleterious	-5.7	high_impact	5.05	0.55	damaging	0.05	damaging	4.15	23.80	deleterious	0.19	0.55	0.64	disease	0.9	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.61	0.9	5.46	8.31	0.59	P	0.98	disease_causing	0.93	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6651	6651	G	A	MI.3472	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	748	250	G	S	Ggc/Agc	-3.34	0	0	probably_damaging	1	deleterious	0.01	neutral	2.76	neutral	-0.71	deleterious	-3.72	high_impact	4.5	0.66	neutral	0.07	damaging	4.17	23.80	deleterious	0.24	0.55	0.28	neutral	0.85	disease	0.59	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-0.92	medium_impact	3.06	high_impact	0.63	0.9	5.46	8.31	0.38	N	0.73	disease_causing	0.76	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6651	6651	G	C	MI.3473	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	748	250	G	R	Ggc/Cgc	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-1.58	deleterious	-5.14	high_impact	5.05	0.48	damaging	0.08	damaging	3.97	23.60	deleterious	0.14	0.55	0.45	neutral	0.92	disease	0.78	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.68	0.9	5.46	8.31	0.67	P	0.95	disease_causing	0.87	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6652	6652	G	T	MI.3474	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	749	250	G	V	gGc/gTc	9.15	1	0	probably_damaging	1	neutral	0.05	neutral	2.84	neutral	-0.28	deleterious	-5.7	high_impact	3.73	0.56	damaging	0.06	damaging	3.75	23.30	deleterious	0.19	0.55	0.24	neutral	0.92	disease	0.68	disease	0.75	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.84	deleterious	-3.58	low_impact	-0.52	medium_impact	2.35	high_impact	0.55	0.9	5.46	8.31	0.45	N	0.93	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6652	6652	G	A	MI.3475	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	749	250	G	D	gGc/gAc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.36	deleterious	-4.58	high_impact	5.05	0.59	damaging	0.05	damaging	3.85	23.40	deleterious	0.18	0.55	0.53	disease	0.9	disease	0.78	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.45	0.9	5.46	8.31	0.75	P	0.97	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6652	6652	G	C	MI.3476	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	749	250	G	A	gGc/gCc	9.15	1	0	probably_damaging	1	neutral	0.24	neutral	3.08	neutral	2.15	deleterious	-3.5	low_impact	1.5	0.54	damaging	0.25	damaging	1.95	15.89	deleterious	0.34	0.55	0.23	neutral	0.59	disease	0.41	neutral	0.42	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.75	deleterious	-3.58	low_impact	-0.09	medium_impact	0.29	medium_impact	0.63	0.9	5.46	8.31	0.5	P	0.64	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6654	6654	T	A	MI.3477	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	751	251	F	I	Ttc/Atc	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-1.79	deleterious	-4.22	high_impact	4.75	0.69	neutral	0.11	damaging	4.45	24.20	deleterious	0.23	0.55	0.39	neutral	0.88	disease	0.69	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.62	0.9	2.53	6.91	0.62	P	0.88	polymorphism	0.82	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6654	6654	T	C	MI.3478	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	751	251	F	L	Ttc/Ctc	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-0.98	deleterious	-4.22	high_impact	4.5	0.67	neutral	0.1	damaging	4.10	23.70	deleterious	0.4	0.55	0.36	neutral	0.85	disease	0.69	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.58	0.9	2.53	6.91	0.42	N	0.83	polymorphism	0.81	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6654	6654	T	G	MI.3479	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	751	251	F	V	Ttc/Gtc	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.62	neutral	-1.34	deleterious	-4.92	high_impact	5.3	0.62	neutral	0.1	damaging	4.14	23.80	deleterious	0.29	0.55	0.42	neutral	0.92	disease	0.75	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.58	0.9	2.53	6.91	0.63	P	0.84	polymorphism	0.69	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8690	8690	A	T	MI.348	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	164	55	K	M	aAa/aTa	2.44	0.98	0	probably_damaging	1	deleterious	0.02	neutral	4.24	deleterious	-3.32	deleterious	-4.72	medium_impact	2.56	0.86	neutral	0.57	neutral	3.68	23.30	deleterious	0.25	0.65	0.87	disease	0.69	disease	0.34	neutral	0.61	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-3.6	low_impact	-0.66	medium_impact	1.1	medium_impact	0.41	0.9	49.12	8.68	0.45	N	0.53	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6655	6655	T	C	MI.3480	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	752	251	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.99	deleterious	-5.62	high_impact	4.95	0.63	neutral	0.14	damaging	4.26	23.90	deleterious	0.28	0.55	0.57	disease	0.88	disease	0.74	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.33	0.9	2.53	6.91	0.73	P	0.84	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6655	6655	T	A	MI.3481	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	752	251	F	Y	tTc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-1.2	neutral	-2.11	high_impact	4.61	0.67	neutral	0.1	damaging	4.30	24.00	deleterious	0.25	0.55	0.42	neutral	0.84	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.16	high_impact	0.63	0.9	2.53	6.91	0.54	P	0.59	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6655	6655	T	G	MI.3482	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	752	251	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.33	deleterious	-5.64	high_impact	5.3	0.64	neutral	0.1	damaging	4.13	23.80	deleterious	0.25	0.55	0.78	disease	0.87	disease	0.77	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.27	0.9	2.53	6.91	0.72	P	0.91	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6656	6656	C	A	MI.3483	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	753	251	F	L	ttC/ttA	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-0.98	deleterious	-4.22	high_impact	4.5	0.67	neutral	0.1	damaging	4.65	24.50	deleterious	0.4	0.55	0.36	neutral	0.85	disease	0.69	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.58	0.9	2.53	6.91	0.53	P	0.83	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6656	6656	C	G	MI.3484	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	753	251	F	L	ttC/ttG	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-0.98	deleterious	-4.22	high_impact	4.5	0.67	neutral	0.1	damaging	4.37	24.10	deleterious	0.4	0.55	0.36	neutral	0.85	disease	0.69	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.58	0.9	2.53	6.91	0.5	P	0.83	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6657	6657	G	T	MI.3485	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	754	252	G	W	Gga/Tga	-5.66	0	0	probably_damaging	1	deleterious	0	neutral	1.84	deleterious	-10.16	deleterious	-5.7	high_impact	4.96	0.56	damaging	0.06	damaging	4.46	24.20	deleterious	0.15	0.55	0.97	disease	0.93	disease	0.79	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.26	0.9	4.48	7.98	0.47	N	0.83	disease_causing	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6657	6657	G	C	MI.3486	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	754	252	G	R	Gga/Cga	-5.66	0	0	probably_damaging	1	deleterious	0	neutral	1.85	deleterious	-7.33	deleterious	-5.69	high_impact	5.31	0.46	damaging	0.07	damaging	3.95	23.60	deleterious	0.11	0.55	0.85	disease	0.93	disease	0.82	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.64	0.9	4.48	7.98	0.55	P	0.95	disease_causing	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6658	6658	G	A	MI.3487	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	755	252	G	E	gGa/gAa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	1.85	deleterious	-7.16	deleterious	-5.69	high_impact	5.31	0.51	damaging	0.06	damaging	3.84	23.40	deleterious	0.14	0.55	0.81	disease	0.91	disease	0.83	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.53	0.9	4.48	7.98	0.64	P	0.93	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6658	6658	G	C	MI.3488	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	755	252	G	A	gGa/gCa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.31	neutral	-1.3	deleterious	-4.26	high_impact	4.5	0.7	neutral	0.1	damaging	3.11	22.50	deleterious	0.18	0.55	0.49	neutral	0.77	disease	0.75	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.56	0.9	4.48	7.98	0.53	P	0.64	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6658	6658	G	T	MI.3489	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	755	252	G	V	gGa/gTa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	1.86	deleterious	-6.22	deleterious	-6.41	high_impact	5.31	0.54	damaging	0.05	damaging	3.72	23.30	deleterious	0.13	0.55	0.54	disease	0.93	disease	0.77	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.48	0.9	4.48	7.98	0.56	P	0.93	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8691	8691	A	T	MI.349	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	165	55	K	N	aaA/aaT	8.69	1	0	probably_damaging	1	neutral	0.32	neutral	4.48	neutral	0.64	deleterious	-3.46	low_impact	0.92	0.8	neutral	0.53	neutral	2.67	20.60	deleterious	0.67	0.75	0.57	disease	0.6	disease	0.34	neutral	0.5	neutral	0	1	deleterious	0.16	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.11	medium_impact	-0.31	medium_impact	0.64	0.9	49.12	8.68	0.47	N	0.77	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6660	6660	A	G	MI.3490	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	757	253	M	V	Ata/Gta	-5.66	0	0	benign	0	deleterious	0.01	neutral	2.99	neutral	0.92	neutral	-1.44	low_impact	1.55	0.68	neutral	0.3	neutral	0.85	9.74	deleterious	0.57	0.6	0.17	neutral	0.83	disease	0.43	neutral	0.52	disease	0	0.99	deleterious	0.51	deleterious	-2	neutral	0.18	neutral	2.07	high_impact	-0.92	medium_impact	0.33	medium_impact	0.42	0.9	9.36	35.81	0.35	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6660	6660	A	T	MI.3491	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	757	253	M	L	Ata/Tta	-5.66	0	0	benign	0.01	neutral	0.22	neutral	2.97	neutral	0.94	neutral	-0.91	neutral_impact	0.33	0.64	neutral	0.4	neutral	0.28	5.54	deleterious	0.44	0.55	0.17	neutral	0.68	disease	0.36	neutral	0.44	neutral	1	0.77	neutral	0.61	deleterious	-6	neutral	0.17	neutral	1.12	medium_impact	-0.11	medium_impact	-0.79	medium_impact	0.43	0.9	9.36	35.81	0.4	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6660	6660	A	C	MI.3492	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	757	253	M	L	Ata/Cta	-5.66	0	0	benign	0.01	neutral	0.22	neutral	2.97	neutral	0.94	neutral	-0.91	neutral_impact	0.33	0.64	neutral	0.4	neutral	0.18	4.46	deleterious	0.44	0.55	0.17	neutral	0.68	disease	0.36	neutral	0.44	neutral	1	0.77	neutral	0.61	deleterious	-6	neutral	0.17	neutral	1.12	medium_impact	-0.11	medium_impact	-0.79	medium_impact	0.43	0.9	9.36	35.81	0.39	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6661	6661	T	C	MI.3493	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	758	253	M	T	aTa/aCa	7.07	1	0	benign	0.16	deleterious	0	neutral	2.79	neutral	-0.89	deleterious	-3.17	high_impact	3.52	0.62	neutral	0.17	damaging	1.12	11.35	neutral	0.44	0.55	0.31	neutral	0.84	disease	0.64	disease	0.74	disease	5	1	deleterious	0.42	neutral	2	deleterious	0.30	neutral	-0.08	medium_impact	-1.48	low_impact	2.15	high_impact	0.38	0.9	9.36	35.81	0.52	P	0.67	disease_causing	0.64	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6661	6661	T	A	MI.3494	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	758	253	M	K	aTa/aAa	7.07	1	0	benign	0.14	deleterious	0	neutral	2.75	neutral	-2.23	deleterious	-3.64	high_impact	4.22	0.6	damaging	0.11	damaging	2.24	17.75	deleterious	0.17	0.55	0.49	neutral	0.91	disease	0.71	disease	0.79	disease	6	1	deleterious	0.43	neutral	2	deleterious	0.39	neutral	-0.01	medium_impact	-1.48	low_impact	2.8	high_impact	0.33	0.9	9.36	35.81	0.5	P	0.73	disease_causing	0.93	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6662	6662	A	C	MI.3495	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	759	253	M	I	atA/atC	7.53	1	0	benign	0.02	neutral	1	neutral	3.03	neutral	1.79	neutral	-1.18	neutral_impact	-0.06	0.69	neutral	0.97	neutral	-0.26	0.83	neutral	0.55	0.6	0.29	neutral	0.43	neutral	0.31	neutral	0.45	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.15	neutral	0.83	medium_impact	1.86	high_impact	-1.15	low_impact	0.53	0.9	9.36	35.81	0.53	P	0.00	disease_causing	0.92	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6662	6662	A	T	MI.3496	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	759	253	M	I	atA/atT	7.53	1	0	benign	0.02	neutral	1	neutral	3.03	neutral	1.79	neutral	-1.18	neutral_impact	-0.06	0.69	neutral	0.97	neutral	-0.20	1.11	neutral	0.55	0.6	0.29	neutral	0.43	neutral	0.31	neutral	0.45	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.15	neutral	0.83	medium_impact	1.86	high_impact	-1.15	low_impact	0.53	0.9	9.36	35.81	0.54	P	0.00	disease_causing	0.92	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6663	6663	A	G	MI.3497	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	760	254	I	V	Atc/Gtc	-0.57	0.09	0	benign	0	neutral	0.25	neutral	2.85	neutral	0.23	neutral	-0.44	low_impact	1.29	0.67	neutral	0.8	neutral	-0.05	2.10	deleterious	0.62	0.65	0.29	neutral	0.37	neutral	0.42	neutral	0.39	neutral	2	0.75	neutral	0.63	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	-0.07	medium_impact	0.09	medium_impact	0.77	0.9	12.87	13.9	0.55	P	0.17	disease_causing	0.92	0.01	rs200784106	.	.	.	.	.	.	.	2.97	A6663G	Prostate Cancer	+	-	Reported	3	N	P	N,P	neutral
chrM	6663	6663	A	T	MI.3498	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	760	254	I	F	Atc/Ttc	-0.57	0.09	0	possibly_damaging	0.56	deleterious	0	neutral	2.65	neutral	-1.65	deleterious	-2.84	high_impact	4.07	0.62	neutral	0.42	neutral	3.45	23.00	deleterious	0.28	0.55	0.41	neutral	0.89	disease	0.71	disease	0.77	disease	5	1	deleterious	0.22	neutral	5	deleterious	0.73	deleterious	-0.86	medium_impact	-1.48	low_impact	2.66	high_impact	0.83	0.9	12.87	13.9	0.47	N	0.84	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6663	6663	A	C	MI.3499	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	760	254	I	L	Atc/Ctc	-0.57	0.09	0	benign	0.08	deleterious	0	neutral	2.82	neutral	0.08	neutral	-1.42	high_impact	4	0.64	neutral	0.46	neutral	1.92	15.74	deleterious	0.36	0.55	0.34	neutral	0.81	disease	0.6	disease	0.67	disease	3	1	deleterious	0.46	neutral	2	deleterious	0.26	neutral	0.24	medium_impact	-1.48	low_impact	2.59	high_impact	0.79	0.9	12.87	13.9	0.5	N	0.36	disease_causing	0.96	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8542	8542	T	G	MI.35	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	16	6	F	V	Ttc/Gtc	0.13	0.97	0	probably_damaging	0.95	deleterious	0	neutral	3.93	neutral	-1.04	deleterious	-5.93	medium_impact	3.32	0.47	damaging	0.62	neutral	3.95	23.60	deleterious	0.42	0.65	0.73	disease	0.73	disease	0.8	disease	0.78	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.77	deleterious	-1.97	low_impact	-1.4	low_impact	1.75	medium_impact	0.29	0.9	39.82	8.43	0.51	P	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8691	8691	A	C	MI.350	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	165	55	K	N	aaA/aaC	8.69	1	0	probably_damaging	1	neutral	0.32	neutral	4.48	neutral	0.64	deleterious	-3.46	low_impact	0.92	0.8	neutral	0.53	neutral	2.64	20.50	deleterious	0.67	0.75	0.57	disease	0.6	disease	0.34	neutral	0.5	neutral	0	1	deleterious	0.16	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.11	medium_impact	-0.31	medium_impact	0.64	0.9	49.12	8.68	0.46	N	0.77	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6664	6664	T	G	MI.3500	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	761	254	I	S	aTc/aGc	5.91	1	0	possibly_damaging	0.8	deleterious	0	neutral	2.61	neutral	-2.59	deleterious	-4.11	high_impact	5.04	0.73	neutral	0.51	neutral	4.07	23.70	deleterious	0.25	0.55	0.64	disease	0.9	disease	0.7	disease	0.75	disease	5	1	deleterious	0.1	neutral	5	deleterious	0.83	deleterious	-1.32	low_impact	-1.48	low_impact	3.56	high_impact	0.59	0.9	12.87	13.9	0.69	P	0.70	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6664	6664	T	A	MI.3501	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	761	254	I	N	aTc/aAc	5.91	1	0	probably_damaging	0.95	deleterious	0	neutral	2.59	deleterious	-3.84	deleterious	-4.83	high_impact	4.7	0.63	neutral	0.43	neutral	4.56	24.40	deleterious	0.23	0.55	0.79	disease	0.89	disease	0.71	disease	0.78	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.85	deleterious	-1.96	low_impact	-1.48	low_impact	3.24	high_impact	0.63	0.9	12.87	13.9	0.61	P	0.82	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6664	6664	T	C	MI.3502	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	761	254	I	T	aTc/aCc	5.91	1	0	possibly_damaging	0.54	deleterious	0	neutral	2.66	neutral	-1.5	deleterious	-3.26	high_impact	4.24	0.65	neutral	0.45	neutral	3.08	22.50	deleterious	0.4	0.55	0.58	disease	0.83	disease	0.69	disease	0.72	disease	4	1	deleterious	0.23	neutral	5	deleterious	0.72	deleterious	-0.82	medium_impact	-1.48	low_impact	2.82	high_impact	0.72	0.9	12.87	13.9	0.51	P	0.81	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6665	6665	C	G	MI.3503	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	762	254	I	M	atC/atG	7.53	1	0.01	possibly_damaging	0.8	deleterious	0.03	neutral	2.66	neutral	-1.4	neutral	-1.99	medium_impact	3.31	0.68	neutral	0.52	neutral	3.23	22.80	deleterious	0.36	0.55	0.56	disease	0.74	disease	0.62	disease	0.61	disease	2	0.98	deleterious	0.12	neutral	4	deleterious	0.57	deleterious	-1.32	low_impact	-0.65	medium_impact	1.96	medium_impact	0.87	0.9	12.87	13.9	0.49	P	0.68	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6665	6665	C	A	MI.3504	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	762	254	I	M	atC/atA	7.53	1	0.01	possibly_damaging	0.8	deleterious	0.03	neutral	2.66	neutral	-1.4	neutral	-1.99	medium_impact	3.31	0.68	neutral	0.52	neutral	3.63	23.20	deleterious	0.36	0.55	0.56	disease	0.74	disease	0.62	disease	0.61	disease	2	0.98	deleterious	0.12	neutral	4	deleterious	0.57	deleterious	-1.32	low_impact	-0.65	medium_impact	1.96	medium_impact	0.87	0.9	12.87	13.9	0.5	P	0.68	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6666	6666	T	C	MI.3505	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	763	255	S	P	Tcc/Ccc	-4.73	0	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-3.8	deleterious	-3.58	high_impact	4.94	0.41	damaging	0.15	damaging	3.94	23.50	deleterious	0.15	0.55	0.72	disease	0.88	disease	0.8	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.46	high_impact	0.70	0.9	4.87	8.06	0.7	P	0.91	polymorphism	0.94	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6666	6666	T	A	MI.3506	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	763	255	S	T	Tcc/Acc	-4.73	0	0	probably_damaging	0.99	deleterious	0	neutral	2.72	neutral	-2.72	neutral	-2.14	high_impact	3.51	0.5	damaging	0.15	damaging	3.75	23.30	deleterious	0.21	0.55	0.48	neutral	0.79	disease	0.73	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	2.14	high_impact	0.81	0.9	4.87	8.06	0.36	N	0.43	polymorphism	0.99	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6666	6666	T	G	MI.3507	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	763	255	S	A	Tcc/Gcc	-4.73	0	0	probably_damaging	0.99	deleterious	0	neutral	2.73	neutral	-2.32	neutral	-2.14	high_impact	4.94	0.6	neutral	0.17	damaging	3.68	23.30	deleterious	0.24	0.55	0.37	neutral	0.72	disease	0.73	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	3.46	high_impact	0.77	0.9	4.87	8.06	0.67	P	0.35	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6667	6667	C	T	MI.3508	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	764	255	S	F	tCc/tTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.86	deleterious	-4.28	high_impact	4.94	0.39	damaging	0.12	damaging	4.25	23.90	deleterious	0.12	0.55	0.81	disease	0.93	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.46	high_impact	0.47	0.9	4.87	8.06	0.79	P	0.98	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6667	6667	C	G	MI.3509	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	764	255	S	C	tCc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-4.83	deleterious	-3.58	high_impact	5.29	0.48	damaging	0.11	damaging	3.61	23.20	deleterious	0.17	0.55	0.89	disease	0.86	disease	0.72	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.63	0.9	4.87	8.06	0.71	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8692	8692	C	A	MI.351	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	166	56	Q	K	Caa/Aaa	1.52	1	0	probably_damaging	0.97	neutral	0.13	neutral	4.34	neutral	-0.95	deleterious	-3.63	medium_impact	3.15	0.71	neutral	0.14	damaging	3.93	23.50	deleterious	0.53	0.65	0.63	disease	0.82	disease	0.62	disease	0.66	disease	3	0.99	deleterious	0.08	neutral	1	deleterious	0.81	deleterious	-2.19	low_impact	-0.18	medium_impact	1.6	medium_impact	0.44	0.9	50	8.48	0.37	N	0.98	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6667	6667	C	A	MI.3510	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	764	255	S	Y	tCc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.98	neutral	-0.08	deleterious	-4.28	high_impact	5.29	0.51	damaging	0.12	damaging	4.07	23.70	deleterious	0.12	0.55	0.53	disease	0.92	disease	0.74	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.72	0.9	4.87	8.06	0.72	P	0.92	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6669	6669	C	G	MI.3511	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	766	256	H	D	Cat/Gat	-14.45	0	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-0.07	deleterious	-6.25	high_impact	4.15	0.5	damaging	0.03	damaging	3.91	23.50	deleterious	0.22	0.55	0.35	neutral	0.93	disease	0.8	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.73	high_impact	0.73	0.9	3.9	8.83	0.4	N	0.97	polymorphism	0.82	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6669	6669	C	A	MI.3512	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	766	256	H	N	Cat/Aat	-14.45	0	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-0.58	deleterious	-4.85	high_impact	4.5	0.54	damaging	0.04	damaging	4.05	23.70	deleterious	0.42	0.55	0.35	neutral	0.91	disease	0.72	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.68	0.9	3.9	8.83	0.41	N	0.86	polymorphism	0.94	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6669	6669	C	T	MI.3513	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	766	256	H	Y	Cat/Tat	-14.45	0	0	probably_damaging	1	deleterious	0	neutral	2.95	neutral	1.64	deleterious	-4.18	high_impact	4.15	0.54	damaging	0.03	damaging	3.80	23.40	deleterious	0.38	0.55	0.59	disease	0.93	disease	0.72	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.73	high_impact	0.53	0.9	3.9	8.83	0.33	N	0.72	polymorphism	0.93	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6670	6670	A	T	MI.3514	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	767	256	H	L	cAt/cTt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.83	neutral	0.38	deleterious	-7.67	high_impact	3.73	0.66	neutral	0.03	damaging	3.90	23.50	deleterious	0.25	0.55	0.4	neutral	0.95	disease	0.72	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.35	high_impact	0.46	0.9	3.9	8.83	0.5	P	0.92	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6670	6670	A	G	MI.3515	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	767	256	H	R	cAt/cGt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-0.48	deleterious	-5.54	high_impact	4.36	0.57	damaging	0.04	damaging	3.04	22.40	deleterious	0.41	0.55	0.34	neutral	0.94	disease	0.72	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.93	high_impact	0.54	0.9	3.9	8.83	0.47	N	0.85	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6670	6670	A	C	MI.3516	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	767	256	H	P	cAt/cCt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-1.81	deleterious	-6.97	high_impact	5.04	0.48	damaging	0.05	damaging	3.29	22.80	deleterious	0.19	0.55	0.54	disease	0.94	disease	0.82	disease	0.9	disease	8	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.50	0.9	3.9	8.83	0.67	P	0.90	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6671	6671	T	A	MI.3517	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	768	256	H	Q	caT/caA	8.69	1	0.02	probably_damaging	1	neutral	0.19	neutral	2.8	neutral	-0.12	deleterious	-5.48	low_impact	1.81	0.63	neutral	0.04	damaging	3.62	23.20	deleterious	0.46	0.55	0.26	neutral	0.76	disease	0.56	disease	0.49	neutral	0	1	deleterious	0.1	neutral	-2	neutral	0.78	deleterious	-3.58	low_impact	-0.16	medium_impact	0.57	medium_impact	0.79	0.9	3.9	8.83	0.4	N	0.83	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6671	6671	T	G	MI.3518	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	768	256	H	Q	caT/caG	8.69	1	0.02	probably_damaging	1	neutral	0.19	neutral	2.8	neutral	-0.12	deleterious	-5.48	low_impact	1.81	0.63	neutral	0.04	damaging	3.53	23.10	deleterious	0.46	0.55	0.26	neutral	0.76	disease	0.56	disease	0.49	neutral	0	1	deleterious	0.1	neutral	-2	neutral	0.78	deleterious	-3.58	low_impact	-0.16	medium_impact	0.57	medium_impact	0.79	0.9	3.9	8.83	0.39	N	0.83	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6672	6672	A	T	MI.3519	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	769	257	I	F	Att/Ttt	-3.11	0	0	possibly_damaging	0.52	deleterious	0	neutral	2.55	deleterious	-3.24	deleterious	-2.74	high_impact	4.38	0.58	damaging	0.34	neutral	3.16	22.60	deleterious	0.27	0.55	0.64	disease	0.88	disease	0.63	disease	0.72	disease	4	1	deleterious	0.24	neutral	5	deleterious	0.59	deleterious	-0.79	medium_impact	-1.48	low_impact	2.95	high_impact	0.82	0.9	9.75	22.27	0.42	N	0.72	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8692	8692	C	G	MI.352	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	166	56	Q	E	Caa/Gaa	1.52	1	0	probably_damaging	0.94	neutral	0.79	neutral	4.38	neutral	-0.11	deleterious	-2.72	low_impact	1.51	0.74	neutral	0.15	damaging	2.93	22.00	deleterious	0.57	0.65	0.49	neutral	0.5	neutral	0.38	neutral	0.44	neutral	1	0.93	neutral	0.43	neutral	-2	neutral	0.75	deleterious	-1.89	low_impact	0.62	medium_impact	0.2	medium_impact	0.65	0.9	50	8.48	0.3	N	0.94	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6672	6672	A	G	MI.3520	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	769	257	I	V	Att/Gtt	-3.11	0	0	benign	0.06	neutral	0.27	neutral	2.72	neutral	-0.55	neutral	-0.37	low_impact	1.44	0.73	neutral	0.93	neutral	-0.61	0.12	neutral	0.6	0.65	0.24	neutral	0.32	neutral	0.31	neutral	0.42	neutral	2	0.71	neutral	0.61	deleterious	-6	neutral	0.16	neutral	0.37	medium_impact	-0.05	medium_impact	0.23	medium_impact	0.72	0.9	9.75	22.27	0.51	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6672	6672	A	C	MI.3521	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	769	257	I	L	Att/Ctt	-3.11	0	0	benign	0.01	neutral	0.08	neutral	2.76	neutral	-0.71	neutral	-1.28	medium_impact	3.46	0.66	neutral	0.38	neutral	1.55	13.60	neutral	0.31	0.55	0.35	neutral	0.76	disease	0.47	neutral	0.53	disease	1	0.92	neutral	0.54	deleterious	-3	neutral	0.23	neutral	1.12	medium_impact	-0.4	medium_impact	2.1	high_impact	0.78	0.9	9.75	22.27	0.44	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6673	6673	T	C	MI.3522	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	770	257	I	T	aTt/aCt	2.67	0.98	0	possibly_damaging	0.73	deleterious	0.01	neutral	2.5	neutral	-2.85	deleterious	-3.08	medium_impact	2.77	0.62	neutral	0.39	neutral	3.20	22.70	deleterious	0.33	0.55	0.54	disease	0.83	disease	0.43	neutral	0.54	disease	1	0.99	deleterious	0.14	neutral	4	deleterious	0.68	deleterious	-1.16	low_impact	-0.92	medium_impact	1.46	medium_impact	0.63	0.9	9.75	22.27	0.43	N	0.70	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6673	6673	T	G	MI.3523	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	770	257	I	S	aTt/aGt	2.67	0.98	0	possibly_damaging	0.86	neutral	0.13	neutral	2.5	deleterious	-3.4	deleterious	-3.94	high_impact	3.9	0.65	neutral	0.39	neutral	4.19	23.80	deleterious	0.21	0.55	0.51	disease	0.9	disease	0.61	disease	0.68	disease	4	0.94	neutral	0.14	neutral	1	deleterious	0.79	deleterious	-1.5	low_impact	-0.27	medium_impact	2.5	high_impact	0.57	0.9	9.75	22.27	0.54	P	0.61	polymorphism	0.98	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6673	6673	T	A	MI.3524	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	770	257	I	N	aTt/aAt	2.67	0.98	0	probably_damaging	0.96	deleterious	0	neutral	2.47	deleterious	-4.73	deleterious	-4.67	high_impact	4.59	0.66	neutral	0.39	neutral	4.28	24.00	deleterious	0.23	0.55	0.79	disease	0.91	disease	0.64	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.06	low_impact	-1.48	low_impact	3.14	high_impact	0.69	0.9	9.75	22.27	0.54	P	0.71	polymorphism	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6674	6674	T	G	MI.3525	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	771	257	I	M	atT/atG	7.53	1	0	possibly_damaging	0.63	neutral	0.06	neutral	2.53	neutral	-2.75	neutral	-1.75	medium_impact	2.45	0.69	neutral	0.44	neutral	3.07	22.40	deleterious	0.4	0.55	0.51	disease	0.67	disease	0.32	neutral	0.46	neutral	1	0.94	neutral	0.22	neutral	0	NA	0.55	deleterious	-0.97	medium_impact	-0.47	medium_impact	1.16	medium_impact	0.81	0.9	9.75	22.27	0.55	P	0.51	polymorphism	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6674	6674	T	A	MI.3526	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	771	257	I	M	atT/atA	7.53	1	0	possibly_damaging	0.63	neutral	0.06	neutral	2.53	neutral	-2.75	neutral	-1.75	medium_impact	2.45	0.69	neutral	0.44	neutral	3.41	23.00	deleterious	0.4	0.55	0.51	disease	0.67	disease	0.32	neutral	0.46	neutral	1	0.94	neutral	0.22	neutral	0	NA	0.55	deleterious	-0.97	medium_impact	-0.47	medium_impact	1.16	medium_impact	0.81	0.9	9.75	22.27	0.55	P	0.51	polymorphism	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6675	6675	G	A	MI.3527	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	772	258	V	M	Gta/Ata	-5.19	0	0	probably_damaging	1	deleterious	0	neutral	2.6	neutral	-2.22	neutral	-1.57	medium_impact	2.27	0.62	neutral	0.15	damaging	3.66	23.20	deleterious	0.45	0.55	0.55	disease	0.59	disease	0.47	neutral	0.5	neutral	0	1	deleterious	0	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	1	medium_impact	0.96	1	5.85	8.37	0.29	N	0.82	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6675	6675	G	C	MI.3528	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	772	258	V	L	Gta/Cta	-5.19	0	0	probably_damaging	0.97	neutral	0.19	neutral	2.86	neutral	0.27	neutral	-1.05	low_impact	1.15	0.59	damaging	0.12	damaging	3.42	23.00	deleterious	0.32	0.55	0.24	neutral	0.58	disease	0.28	neutral	0.45	neutral	1	0.98	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-2.18	low_impact	-0.16	medium_impact	-0.04	medium_impact	0.75	0.9	5.85	8.37	0.34	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6675	6675	G	T	MI.3529	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	772	258	V	L	Gta/Tta	-5.19	0	0	probably_damaging	0.97	neutral	0.19	neutral	2.86	neutral	0.27	neutral	-1.05	low_impact	1.15	0.59	damaging	0.12	damaging	3.57	23.10	deleterious	0.32	0.55	0.24	neutral	0.58	disease	0.28	neutral	0.45	neutral	1	0.98	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-2.18	low_impact	-0.16	medium_impact	-0.04	medium_impact	0.75	0.9	5.85	8.37	0.34	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8693	8693	A	T	MI.353	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	167	56	Q	L	cAa/cTa	7.3	1	0	probably_damaging	0.97	neutral	0.3	neutral	4.52	neutral	1.17	deleterious	-5.83	low_impact	1.7	0.72	neutral	0.13	damaging	3.39	23.00	deleterious	0.34	0.65	0.58	disease	0.81	disease	0.5	neutral	0.62	disease	2	0.98	neutral	0.17	neutral	-2	neutral	0.80	deleterious	-2.19	low_impact	0.08	medium_impact	0.36	medium_impact	0.23	0.9	50	8.48	0.41	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6676	6676	T	C	MI.3530	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	773	258	V	A	gTa/gCa	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.64	neutral	-1.48	deleterious	-2.79	medium_impact	3.32	0.62	neutral	0.16	damaging	3.50	23.10	deleterious	0.32	0.55	0.38	neutral	0.55	disease	0.58	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	1.97	medium_impact	0.65	0.9	5.85	8.37	0.49	P	0.47	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6676	6676	T	G	MI.3531	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	773	258	V	G	gTa/gGa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-3.86	deleterious	-4.92	high_impact	4.01	0.57	damaging	0.17	damaging	3.71	23.30	deleterious	0.17	0.55	0.69	disease	0.74	disease	0.59	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.6	high_impact	0.57	0.9	5.85	8.37	0.46	N	0.71	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6676	6676	T	A	MI.3532	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	773	258	V	E	gTa/gAa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.12	deleterious	-4.22	high_impact	4.01	0.58	damaging	0.15	damaging	4.54	24.30	deleterious	0.12	0.55	0.7	disease	0.86	disease	0.71	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.6	high_impact	0.55	0.9	5.85	8.37	0.51	P	0.84	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6678	6678	A	C	MI.3533	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	775	259	T	P	Act/Cct	-11.9	0	0	possibly_damaging	0.85	neutral	0.27	neutral	3.28	neutral	2.45	neutral	-1.56	neutral_impact	0.78	0.44	damaging	0.06	damaging	3.33	22.90	deleterious	0.17	0.55	0.22	neutral	0.75	disease	0.46	neutral	0.52	disease	0	0.89	neutral	0.21	neutral	-3	neutral	0.70	deleterious	-1.47	low_impact	-0.05	medium_impact	-0.38	medium_impact	0.76	0.9	9.55	11.35	0.31	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6678	6678	A	G	MI.3534	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	775	259	T	A	Act/Gct	-11.9	0	0	benign	0.02	neutral	1	neutral	3.04	neutral	0.64	neutral	0.14	neutral_impact	0.26	0.68	neutral	0.46	neutral	-0.41	0.36	neutral	0.53	0.6	0.18	neutral	0.26	neutral	0.14	neutral	0.43	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.14	neutral	0.83	medium_impact	1.86	high_impact	-0.86	medium_impact	0.63	0.9	9.55	11.35	0.39	N	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6678	6678	A	T	MI.3535	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	775	259	T	S	Act/Tct	-11.9	0	0	benign	0.28	neutral	0.91	neutral	3.05	neutral	0.79	neutral	0.99	neutral_impact	-1.3	0.61	neutral	0.23	damaging	-1.15	0.01	neutral	0.42	0.55	0.22	neutral	0.07	neutral	0.1	neutral	0.22	neutral	6	0.17	neutral	0.82	deleterious	-6	neutral	0.22	neutral	-0.37	medium_impact	0.75	medium_impact	-2.3	low_impact	0.80	0.9	9.55	11.35	0.37	N	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6679	6679	C	T	MI.3536	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	776	259	T	I	aCt/aTt	1.29	0.85	0	possibly_damaging	0.82	neutral	0.12	neutral	3.01	neutral	0.16	neutral	-1.67	neutral_impact	0.22	0.51	damaging	0.06	damaging	3.63	23.20	deleterious	0.41	0.55	0.33	neutral	0.51	disease	0.16	neutral	0.41	neutral	2	0.93	neutral	0.15	neutral	-3	neutral	0.63	deleterious	-1.38	low_impact	-0.29	medium_impact	-0.9	medium_impact	0.78	0.9	9.55	11.35	0.39	N	0.92	polymorphism	0.91	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6679	6679	C	G	MI.3537	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	776	259	T	S	aCt/aGt	1.29	0.85	0	benign	0.28	neutral	0.91	neutral	3.05	neutral	0.79	neutral	0.99	neutral_impact	-1.3	0.61	neutral	0.23	damaging	-1.01	0.02	neutral	0.42	0.55	0.22	neutral	0.07	neutral	0.1	neutral	0.22	neutral	6	0.17	neutral	0.82	deleterious	-6	neutral	0.22	neutral	-0.37	medium_impact	0.75	medium_impact	-2.3	low_impact	0.80	0.9	9.55	11.35	0.29	N	0.79	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6679	6679	C	A	MI.3538	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	776	259	T	N	aCt/aAt	1.29	0.85	0	possibly_damaging	0.85	neutral	0.14	neutral	2.96	neutral	-1.23	neutral	-0.72	medium_impact	2.02	0.51	damaging	0.09	damaging	2.41	18.86	deleterious	0.49	0.55	0.46	neutral	0.66	disease	0.28	neutral	0.49	neutral	0	0.93	neutral	0.15	neutral	0	NA	0.65	deleterious	-1.47	low_impact	-0.25	medium_impact	0.77	medium_impact	0.82	0.9	9.55	11.35	0.36	N	0.80	polymorphism	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6681	6681	T	G	MI.3539	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	778	260	Y	D	Tac/Gac	-20	0	0	possibly_damaging	0.85	deleterious	0.04	neutral	2.97	neutral	0.61	neutral	-0.91	low_impact	1.23	0.66	neutral	0.36	neutral	2.78	21.30	deleterious	0.41	0.55	0.53	disease	0.74	disease	0.45	neutral	0.53	disease	1	0.98	neutral	0.1	neutral	1	deleterious	0.76	deleterious	-1.47	low_impact	-0.58	medium_impact	0.04	medium_impact	0.48	0.9	11.5	20.69	0.34	N	0.84	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8693	8693	A	C	MI.354	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	167	56	Q	P	cAa/cCa	7.3	1	0	probably_damaging	0.98	neutral	0.07	neutral	4.31	neutral	-2.43	deleterious	-5.53	high_impact	3.84	0.64	neutral	0.15	damaging	2.97	22.10	deleterious	0.18	0.65	0.86	disease	0.88	disease	0.74	disease	0.83	disease	7	1	deleterious	0.05	neutral	2	deleterious	0.89	deleterious	-2.36	low_impact	-0.34	medium_impact	2.19	high_impact	0.39	0.9	50	8.48	0.54	P	0.97	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6681	6681	T	A	MI.3540	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	778	260	Y	N	Tac/Aac	-20	0	0	possibly_damaging	0.8	neutral	0.18	neutral	3	neutral	1.36	neutral	-0.21	neutral_impact	-0.91	0.69	neutral	0.42	neutral	2.59	20.10	deleterious	0.36	0.55	0.45	neutral	0.51	disease	0.27	neutral	0.43	neutral	1	0.89	neutral	0.19	neutral	-3	neutral	0.65	deleterious	-1.32	low_impact	-0.17	medium_impact	-1.94	low_impact	0.36	0.9	11.5	20.69	0.4	N	0.78	polymorphism	0.96	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6681	6681	T	C	MI.3541	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	778	260	Y	H	Tac/Cac	-20	0	0	benign	0.06	neutral	0.28	neutral	2.99	neutral	0.02	neutral	0.94	neutral_impact	-1.27	0.69	neutral	0.81	neutral	-0.68	0.08	neutral	0.64	0.7	0.33	neutral	0.26	neutral	0.19	neutral	0.44	neutral	1	0.69	neutral	0.61	deleterious	-6	neutral	0.20	neutral	0.37	medium_impact	-0.04	medium_impact	-2.27	low_impact	0.49	0.9	11.5	20.69	0.55	N	0.02	polymorphism	1	0.01	rs879180101	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6682	6682	A	G	MI.3542	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	779	260	Y	C	tAc/tGc	4.76	1	0	probably_damaging	0.98	deleterious	0.04	neutral	2.96	neutral	-0.95	neutral	-2.17	low_impact	1.46	0.64	neutral	0.28	neutral	2.40	18.83	deleterious	0.39	0.55	0.56	disease	0.75	disease	0.28	neutral	0.54	disease	1	1	deleterious	0.03	neutral	2	deleterious	0.78	deleterious	-2.35	low_impact	-0.58	medium_impact	0.25	medium_impact	0.17	0.9	11.5	20.69	0.41	N	0.69	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6682	6682	A	T	MI.3543	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	779	260	Y	F	tAc/tTc	4.76	1	0	possibly_damaging	0.55	neutral	0.37	neutral	3.01	neutral	-0.02	neutral	-1.07	neutral_impact	-0.08	0.71	neutral	0.75	neutral	1.15	11.46	neutral	0.42	0.55	0.32	neutral	0.44	neutral	0.17	neutral	0.46	neutral	1	0.63	neutral	0.41	neutral	-3	neutral	0.51	deleterious	-0.84	medium_impact	0.06	medium_impact	-1.17	low_impact	0.41	0.9	11.5	20.69	0.56	P	0.42	disease_causing	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6682	6682	A	C	MI.3544	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	779	260	Y	S	tAc/tCc	4.76	1	0	possibly_damaging	0.8	neutral	0.24	neutral	3.02	neutral	1.28	neutral	-0.39	neutral_impact	-0.7	0.68	neutral	0.42	neutral	2.06	16.57	deleterious	0.3	0.55	0.23	neutral	0.49	neutral	0.27	neutral	0.41	neutral	2	0.86	neutral	0.22	neutral	-3	neutral	0.64	deleterious	-1.32	low_impact	-0.09	medium_impact	-1.75	low_impact	0.34	0.9	11.5	20.69	0.51	N	0.75	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6684	6684	T	C	MI.3545	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	781	261	Y	H	Tac/Cac	-6.35	0	0	benign	0.06	neutral	0.13	neutral	2.76	neutral	-1.69	neutral	-0.2	neutral_impact	0.68	0.54	damaging	0.09	damaging	0.16	4.30	deleterious	0.62	0.65	0.38	neutral	0.56	disease	0.42	neutral	0.45	neutral	1	0.86	neutral	0.54	deleterious	-6	neutral	0.27	neutral	0.37	medium_impact	-0.27	medium_impact	-0.47	medium_impact	0.31	0.9	1.75	9.15	0.36	N	0.61	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6684	6684	T	A	MI.3546	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	781	261	Y	N	Tac/Aac	-6.35	0	0	possibly_damaging	0.79	neutral	0.1	neutral	2.75	neutral	-1.7	neutral	-0.93	low_impact	1.11	0.55	damaging	0.07	damaging	2.76	21.20	deleterious	0.45	0.55	0.25	neutral	0.78	disease	0.44	neutral	0.54	disease	1	0.93	neutral	0.16	neutral	-3	neutral	0.68	deleterious	-1.3	low_impact	-0.34	medium_impact	-0.07	medium_impact	0.40	0.9	1.75	9.15	0.28	N	0.94	polymorphism	0.88	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6684	6684	T	G	MI.3547	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	781	261	Y	D	Tac/Gac	-6.35	0	0	possibly_damaging	0.84	deleterious	0.04	neutral	2.74	deleterious	-3	neutral	-0.87	medium_impact	2.17	0.53	damaging	0.05	damaging	2.77	21.20	deleterious	0.42	0.55	0.45	neutral	0.85	disease	0.67	disease	0.74	disease	5	0.98	neutral	0.1	neutral	4	deleterious	0.79	deleterious	-1.43	low_impact	-0.58	medium_impact	0.91	medium_impact	0.43	0.9	1.75	9.15	0.28	N	0.98	polymorphism	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6685	6685	A	T	MI.3548	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	782	261	Y	F	tAc/tTc	5.68	1	0	possibly_damaging	0.54	neutral	0.32	neutral	2.98	neutral	1.76	neutral	-1.27	neutral_impact	0.07	0.57	damaging	0.05	damaging	1.49	13.27	neutral	0.48	0.55	0.22	neutral	0.45	neutral	0.28	neutral	0.44	neutral	1	0.67	neutral	0.39	neutral	-3	neutral	0.55	deleterious	-0.82	medium_impact	0.01	medium_impact	-1.03	low_impact	0.29	0.9	1.75	9.15	0.52	P	0.50	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6685	6685	A	G	MI.3549	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	782	261	Y	C	tAc/tGc	5.68	1	0	probably_damaging	0.98	deleterious	0.03	neutral	2.75	neutral	-2.17	deleterious	-2.71	medium_impact	2.35	0.52	damaging	0.05	damaging	2.43	18.98	deleterious	0.36	0.55	0.62	disease	0.85	disease	0.44	neutral	0.74	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.84	deleterious	-2.35	low_impact	-0.65	medium_impact	1.07	medium_impact	0.17	0.9	1.75	9.15	0.41	N	0.89	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8693	8693	A	G	MI.355	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	167	56	Q	R	cAa/cGa	7.3	1	0	probably_damaging	0.97	neutral	0.12	neutral	4.35	neutral	-0.79	deleterious	-3.59	medium_impact	3.49	0.76	neutral	0.15	damaging	3.02	22.30	deleterious	0.58	0.7	0.73	disease	0.84	disease	0.64	disease	0.71	disease	4	0.99	deleterious	0.08	neutral	1	deleterious	0.86	deleterious	-2.19	low_impact	-0.2	medium_impact	1.89	medium_impact	0.38	0.9	50	8.48	0.55	P	0.87	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6685	6685	A	C	MI.3550	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	782	261	Y	S	tAc/tCc	5.68	1	0	possibly_damaging	0.79	neutral	0.07	neutral	2.79	neutral	-0.46	neutral	-0.82	neutral_impact	0.77	0.53	damaging	0.07	damaging	2.25	17.82	deleterious	0.29	0.55	0.31	neutral	0.7	disease	0.52	disease	0.53	disease	1	0.95	neutral	0.14	neutral	-3	neutral	0.70	deleterious	-1.3	low_impact	-0.43	medium_impact	-0.39	medium_impact	0.42	0.9	1.75	9.15	0.49	N	0.90	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6687	6687	T	A	MI.3551	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	784	262	S	T	Tcc/Acc	-6.35	0	0	probably_damaging	0.97	neutral	0.34	neutral	2.86	neutral	-1.12	neutral	-1.13	medium_impact	2.49	0.63	neutral	0.24	damaging	2.81	21.40	deleterious	0.33	0.55	0.43	neutral	0.69	disease	0.33	neutral	0.48	neutral	1	0.98	neutral	0.19	neutral	1	deleterious	0.74	deleterious	-2.18	low_impact	0.03	medium_impact	1.2	medium_impact	0.74	0.9	3.51	10.51	0.35	N	0.43	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6687	6687	T	G	MI.3552	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	784	262	S	A	Tcc/Gcc	-6.35	0	0	probably_damaging	0.99	neutral	0.26	neutral	2.97	neutral	-0.16	neutral	-1.1	medium_impact	2.47	0.71	neutral	0.77	neutral	2.43	19.00	deleterious	0.42	0.55	0.23	neutral	0.53	disease	0.34	neutral	0.42	neutral	2	0.99	deleterious	0.14	neutral	1	deleterious	0.66	deleterious	-2.64	low_impact	-0.06	medium_impact	1.18	medium_impact	0.70	0.9	3.51	10.51	0.45	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6687	6687	T	C	MI.3553	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	784	262	S	P	Tcc/Ccc	-6.35	0	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.52	deleterious	-2.71	high_impact	4.68	0.53	damaging	0.12	damaging	4.09	23.70	deleterious	0.25	0.55	0.71	disease	0.89	disease	0.61	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.50	0.9	3.51	10.51	0.51	N	0.91	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6688	6688	C	T	MI.3554	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	785	262	S	F	tCc/tTc	0.36	0.29	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-2.6	deleterious	-3.16	high_impact	4.47	0.56	damaging	0.11	damaging	4.30	24.00	deleterious	0.24	0.55	0.6	disease	0.91	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.03	high_impact	0.34	0.9	3.51	10.51	0.4	N	0.98	polymorphism	0.97	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6688	6688	C	G	MI.3555	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	785	262	S	C	tCc/tGc	0.36	0.29	0	probably_damaging	1	deleterious	0.01	neutral	2.74	deleterious	-3.86	neutral	-2.42	medium_impact	3.03	0.6	neutral	0.15	damaging	3.62	23.20	deleterious	0.34	0.55	0.76	disease	0.85	disease	0.52	disease	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.58	low_impact	-0.92	medium_impact	1.7	medium_impact	0.70	0.9	3.51	10.51	0.27	N	0.85	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6688	6688	C	A	MI.3556	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	785	262	S	Y	tCc/tAc	0.36	0.29	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-2.85	deleterious	-3.19	high_impact	3.98	0.61	neutral	0.11	damaging	4.11	23.70	deleterious	0.25	0.55	0.53	disease	0.91	disease	0.66	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.58	high_impact	0.59	0.9	3.51	10.51	0.3	N	0.92	polymorphism	0.98	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6690	6690	G	T	MI.3557	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	787	263	G	W	Gga/Tga	-5.89	0	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-6.32	deleterious	-4.96	high_impact	4.8	0.65	neutral	0.08	damaging	4.46	24.20	deleterious	0.19	0.55	0.9	disease	0.92	disease	0.63	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.33	high_impact	0.46	0.9	8.19	30.49	0.56	P	0.83	polymorphism	0.61	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6690	6690	G	C	MI.3558	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	787	263	G	R	Gga/Cga	-5.89	0	0	probably_damaging	0.94	deleterious	0	neutral	2.75	neutral	-1.55	deleterious	-4.62	medium_impact	3.02	0.57	damaging	0.1	damaging	4.00	23.60	deleterious	0.26	0.55	0.58	disease	0.91	disease	0.63	disease	0.7	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.86	deleterious	-1.88	low_impact	-1.48	low_impact	1.69	medium_impact	0.71	0.9	8.19	30.49	0.23	N	0.95	polymorphism	0.72	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6691	6691	G	C	MI.3559	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	788	263	G	A	gGa/gCa	6.14	1	0	possibly_damaging	0.55	neutral	0.09	neutral	2.66	neutral	-2.87	deleterious	-3.26	medium_impact	2.81	0.67	neutral	0.21	damaging	2.08	16.70	deleterious	0.26	0.55	0.32	neutral	0.7	disease	0.4	neutral	0.52	disease	0	0.9	neutral	0.27	neutral	0	NA	0.56	deleterious	-0.84	medium_impact	-0.37	medium_impact	1.5	medium_impact	0.55	0.9	8.19	30.49	0.51	P	0.64	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8694	8694	A	C	MI.356	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	168	56	Q	H	caA/caC	8.69	1	0	probably_damaging	1	neutral	0.21	neutral	4.31	neutral	-2.27	deleterious	-4.58	medium_impact	2	0.82	neutral	0.18	damaging	3.20	22.70	deleterious	0.55	0.65	0.84	disease	0.68	disease	0.42	neutral	0.63	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	-0.03	medium_impact	0.62	medium_impact	0.59	0.9	50	8.48	0.49	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6691	6691	G	T	MI.3560	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	788	263	G	V	gGa/gTa	6.14	1	0	probably_damaging	0.97	deleterious	0.01	neutral	2.63	deleterious	-3.93	deleterious	-5.29	medium_impact	3.45	0.61	neutral	0.09	damaging	3.75	23.30	deleterious	0.22	0.55	0.51	disease	0.92	disease	0.56	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-2.18	low_impact	-0.92	medium_impact	2.09	high_impact	0.44	0.9	8.19	30.49	0.4	N	0.93	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6691	6691	G	A	MI.3561	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	788	263	G	E	gGa/gAa	6.14	1	0	possibly_damaging	0.88	deleterious	0.01	neutral	2.71	neutral	-2.05	deleterious	-4.6	high_impact	4.46	0.63	neutral	0.09	damaging	3.89	23.50	deleterious	0.22	0.55	0.5	disease	0.9	disease	0.62	disease	0.75	disease	5	1	deleterious	0.07	neutral	5	deleterious	0.82	deleterious	-1.57	low_impact	-0.92	medium_impact	3.02	high_impact	0.50	0.9	8.19	30.49	0.49	P	0.93	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6693	6693	A	G	MI.3562	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	790	264	K	E	Aaa/Gaa	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-2.97	deleterious	-2.86	high_impact	4.58	0.53	damaging	0.18	damaging	4.05	23.70	deleterious	0.39	0.55	0.32	neutral	0.91	disease	0.69	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.54	0.9	3.12	6.71	0.44	N	0.75	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6693	6693	A	C	MI.3563	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	790	264	K	Q	Aaa/Caa	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-3.09	deleterious	-2.86	high_impact	3.81	0.64	neutral	0.13	damaging	3.52	23.10	deleterious	0.4	0.55	0.43	neutral	0.85	disease	0.52	disease	0.62	disease	2	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.42	high_impact	0.70	0.9	3.12	6.71	0.31	N	0.64	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6694	6694	A	C	MI.3564	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	791	264	K	T	aAa/aCa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-2.92	deleterious	-4.26	high_impact	4.43	0.63	neutral	0.15	damaging	3.44	23.00	deleterious	0.25	0.55	0.41	neutral	0.91	disease	0.66	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.99	high_impact	0.56	0.9	3.12	6.71	0.48	N	0.76	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6694	6694	A	T	MI.3565	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	791	264	K	M	aAa/aTa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-4.93	deleterious	-4.28	high_impact	4.78	0.67	neutral	0.14	damaging	3.70	23.30	deleterious	0.18	0.55	0.76	disease	0.89	disease	0.63	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.54	0.9	3.12	6.71	0.7	P	0.89	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6695	6695	A	T	MI.3566	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	792	264	K	N	aaA/aaT	8.69	1	0	probably_damaging	1	neutral	0.06	neutral	2.64	neutral	-2.93	deleterious	-3.56	medium_impact	3.06	0.55	damaging	0.11	damaging	3.76	23.30	deleterious	0.45	0.55	0.45	neutral	0.87	disease	0.55	disease	0.5	neutral	0	1	deleterious	0.03	neutral	1	deleterious	0.82	deleterious	-3.58	low_impact	-0.47	medium_impact	1.73	medium_impact	0.55	0.9	3.12	6.71	0.5	P	0.76	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6695	6695	A	C	MI.3567	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	792	264	K	N	aaA/aaC	8.69	1	0	probably_damaging	1	neutral	0.06	neutral	2.64	neutral	-2.93	deleterious	-3.56	medium_impact	3.06	0.55	damaging	0.11	damaging	3.68	23.30	deleterious	0.45	0.55	0.45	neutral	0.87	disease	0.55	disease	0.5	neutral	0	1	deleterious	0.03	neutral	1	deleterious	0.82	deleterious	-3.58	low_impact	-0.47	medium_impact	1.73	medium_impact	0.55	0.9	3.12	6.71	0.48	P	0.76	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6696	6696	A	C	MI.3568	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	793	265	K	Q	Aaa/Caa	4.06	1	0	benign	0	deleterious	0.03	neutral	2.61	neutral	-2.71	neutral	-1.81	high_impact	3.75	0.64	neutral	0.68	neutral	3.16	22.60	deleterious	0.49	0.55	0.72	disease	0.84	disease	0.47	neutral	0.65	disease	3	0.97	neutral	0.52	deleterious	2	deleterious	0.33	neutral	2.07	high_impact	-0.65	medium_impact	2.36	high_impact	0.79	0.9	2.73	7.44	0.54	P	0.55	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6696	6696	A	G	MI.3569	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	793	265	K	E	Aaa/Gaa	4.06	1	0	benign	0.04	deleterious	0.03	neutral	2.65	neutral	-2.33	neutral	-2.03	medium_impact	2.77	0.59	damaging	0.78	neutral	3.70	23.30	deleterious	0.4	0.55	0.78	disease	0.91	disease	0.42	neutral	0.65	disease	3	0.97	neutral	0.5	deleterious	1	deleterious	0.41	neutral	0.54	medium_impact	-0.65	medium_impact	1.46	medium_impact	0.78	0.9	2.73	7.44	0.49	N	0.07	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8694	8694	A	T	MI.357	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	168	56	Q	H	caA/caT	8.69	1	0	probably_damaging	1	neutral	0.21	neutral	4.31	neutral	-2.27	deleterious	-4.58	medium_impact	2	0.82	neutral	0.18	damaging	3.30	22.90	deleterious	0.55	0.65	0.84	disease	0.68	disease	0.42	neutral	0.63	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	-0.03	medium_impact	0.62	medium_impact	0.59	0.9	50	8.48	0.49	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6697	6697	A	T	MI.3570	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	794	265	K	M	aAa/aTa	7.07	1	0	possibly_damaging	0.64	deleterious	0.01	neutral	2.54	deleterious	-4.67	deleterious	-2.91	medium_impact	3.46	0.65	neutral	0.65	neutral	3.72	23.30	deleterious	0.24	0.55	0.93	disease	0.86	disease	0.47	neutral	0.75	disease	5	0.99	deleterious	0.19	neutral	4	deleterious	0.66	deleterious	-0.99	medium_impact	-0.92	medium_impact	2.1	high_impact	0.61	0.9	2.73	7.44	0.49	P	0.70	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6697	6697	A	C	MI.3571	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	794	265	K	T	aAa/aCa	7.07	1	0	benign	0.27	deleterious	0.01	neutral	2.6	deleterious	-3.1	deleterious	-2.86	high_impact	3.54	0.63	neutral	0.59	neutral	3.43	23.00	deleterious	0.34	0.55	0.67	disease	0.9	disease	0.59	disease	0.65	disease	3	0.99	deleterious	0.37	neutral	2	deleterious	0.52	deleterious	-0.35	medium_impact	-0.92	medium_impact	2.17	high_impact	0.77	0.9	2.73	7.44	0.51	P	0.59	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6698	6698	A	C	MI.3572	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	795	265	K	N	aaA/aaC	5.68	1	0	benign	0.21	neutral	0.07	neutral	2.62	deleterious	-3.16	neutral	-2.26	medium_impact	2	0.59	damaging	0.65	neutral	2.66	20.60	deleterious	0.61	0.65	0.82	disease	0.78	disease	0.35	neutral	0.6	disease	2	0.92	neutral	0.43	neutral	-3	neutral	0.58	deleterious	-0.22	medium_impact	-0.43	medium_impact	0.75	medium_impact	0.80	0.9	2.73	7.44	0.52	P	0.62	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6698	6698	A	T	MI.3573	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	795	265	K	N	aaA/aaT	5.68	1	0	benign	0.21	neutral	0.07	neutral	2.62	deleterious	-3.16	neutral	-2.26	medium_impact	2	0.59	damaging	0.65	neutral	2.80	21.40	deleterious	0.61	0.65	0.82	disease	0.78	disease	0.35	neutral	0.6	disease	2	0.92	neutral	0.43	neutral	-3	neutral	0.58	deleterious	-0.22	medium_impact	-0.43	medium_impact	0.75	medium_impact	0.80	0.9	2.73	7.44	0.51	P	0.62	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6699	6699	G	C	MI.3574	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	796	266	E	Q	Gaa/Caa	2.67	1	0	probably_damaging	0.98	neutral	0.09	neutral	2.75	neutral	-0.77	neutral	-1.94	medium_impact	2.31	0.58	damaging	0.18	damaging	2.25	17.86	deleterious	0.43	0.55	0.3	neutral	0.71	disease	0.23	neutral	0.44	neutral	1	0.99	deleterious	0.06	neutral	1	deleterious	0.79	deleterious	-2.35	low_impact	-0.37	medium_impact	1.03	medium_impact	0.70	0.9	3.51	8.4	0.46	N	0.66	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6699	6699	G	A	MI.3575	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	796	266	E	K	Gaa/Aaa	2.67	1	0	probably_damaging	0.97	deleterious	0	neutral	2.8	neutral	-0.03	deleterious	-2.67	high_impact	3.77	0.54	damaging	0.12	damaging	4.51	24.30	deleterious	0.32	0.55	0.27	neutral	0.92	disease	0.46	neutral	0.65	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.18	low_impact	-1.48	low_impact	2.38	high_impact	0.63	0.9	3.51	8.4	0.45	N	0.72	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6700	6700	A	T	MI.3576	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	797	266	E	V	gAa/gTa	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.71	neutral	-1.37	deleterious	-4.77	high_impact	3.77	0.55	damaging	0.15	damaging	4.06	23.70	deleterious	0.25	0.55	0.2	neutral	0.94	disease	0.47	neutral	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.38	high_impact	0.63	0.9	3.51	8.4	0.44	N	0.67	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6700	6700	A	G	MI.3577	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	797	266	E	G	gAa/gGa	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.71	neutral	-1.53	deleterious	-4.72	high_impact	3.65	0.48	damaging	0.19	damaging	4.18	23.80	deleterious	0.31	0.55	0.3	neutral	0.87	disease	0.5	neutral	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	2.27	high_impact	0.58	0.9	3.51	8.4	0.49	P	0.67	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6700	6700	A	C	MI.3578	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	797	266	E	A	gAa/gCa	7.53	1	0	probably_damaging	0.98	deleterious	0.04	neutral	2.74	neutral	-0.86	deleterious	-3.98	high_impact	3.77	0.65	neutral	0.16	damaging	3.63	23.20	deleterious	0.33	0.55	0.31	neutral	0.87	disease	0.49	neutral	0.64	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.80	deleterious	-2.35	low_impact	-0.58	medium_impact	2.38	high_impact	0.65	0.9	3.51	8.4	0.48	P	0.71	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6701	6701	A	T	MI.3579	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	798	266	E	D	gaA/gaT	8.69	1	0.01	possibly_damaging	0.9	deleterious	0	neutral	2.72	neutral	-1.21	neutral	-2.04	high_impact	3.7	0.55	damaging	0.17	damaging	3.75	23.30	deleterious	0.36	0.55	0.37	neutral	0.84	disease	0.37	neutral	0.64	disease	3	1	deleterious	0.05	neutral	5	deleterious	0.77	deleterious	-1.65	low_impact	-1.48	low_impact	2.32	high_impact	0.77	0.9	3.51	8.4	0.57	P	0.69	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8695	8695	A	T	MI.358	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	169	57	M	L	Atg/Ttg	3.83	1	0	possibly_damaging	0.81	neutral	0.96	neutral	4.62	neutral	2.65	neutral	-0.23	neutral_impact	-1.15	0.88	neutral	0.95	neutral	0.37	6.36	deleterious	0.53	0.65	0.45	neutral	0.18	neutral	0.25	neutral	0.28	neutral	4	0.8	neutral	0.58	deleterious	-3	neutral	0.52	deleterious	-1.35	low_impact	1.07	medium_impact	-2.08	low_impact	0.61	0.9	14.16	15.31	0.45	N	0.94	disease_causing	0.61	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6701	6701	A	C	MI.3580	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	798	266	E	D	gaA/gaC	8.69	1	0.01	possibly_damaging	0.9	deleterious	0	neutral	2.72	neutral	-1.21	neutral	-2.04	high_impact	3.7	0.55	damaging	0.17	damaging	3.65	23.20	deleterious	0.36	0.55	0.37	neutral	0.84	disease	0.37	neutral	0.64	disease	3	1	deleterious	0.05	neutral	5	deleterious	0.77	deleterious	-1.65	low_impact	-1.48	low_impact	2.32	high_impact	0.77	0.9	3.51	8.4	0.57	P	0.69	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6702	6702	C	A	MI.3581	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	799	267	P	T	Cca/Aca	-0.1	0.34	0	probably_damaging	1	neutral	0.45	neutral	3.02	neutral	-0.14	neutral	-1.37	neutral_impact	-0.3	0.54	damaging	0.1	damaging	1.53	13.47	neutral	0.4	0.55	0.25	neutral	0.29	neutral	0.22	neutral	0.44	neutral	1	1	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-3.58	low_impact	0.14	medium_impact	-1.38	low_impact	0.50	0.9	1.36	6.61	0.29	N	0.80	disease_causing	0.98	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6702	6702	C	T	MI.3582	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	799	267	P	S	Cca/Tca	-0.1	0.34	0	probably_damaging	1	neutral	0.11	neutral	3	neutral	-0.18	neutral	-2.19	neutral_impact	0.48	0.49	damaging	0.06	damaging	2.36	18.57	deleterious	0.45	0.55	0.2	neutral	0.45	neutral	0.26	neutral	0.46	neutral	1	1	deleterious	0.06	neutral	-2	neutral	0.69	deleterious	-3.58	low_impact	-0.31	medium_impact	-0.66	medium_impact	0.28	0.9	1.36	6.61	0.33	N	0.85	disease_causing	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6702	6702	C	G	MI.3583	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	799	267	P	A	Cca/Gca	-0.1	0.34	0	probably_damaging	0.99	neutral	0.39	neutral	3.02	neutral	0.3	neutral	-2.3	neutral_impact	0.54	0.52	damaging	0.17	damaging	1.37	12.62	neutral	0.41	0.55	0.22	neutral	0.32	neutral	0.26	neutral	0.45	neutral	1	0.99	deleterious	0.2	neutral	-2	neutral	0.68	deleterious	-2.64	low_impact	0.09	medium_impact	-0.6	medium_impact	0.55	0.9	1.36	6.61	0.34	N	0.76	disease_causing	0.96	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6703	6703	C	T	MI.3584	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	800	267	P	L	cCa/cTa	5.68	1	0	probably_damaging	1	neutral	0.31	neutral	3.27	neutral	2.3	deleterious	-3.68	low_impact	1.55	0.49	damaging	0.04	damaging	4.35	24.10	deleterious	0.37	0.55	0.27	neutral	0.69	disease	0.43	neutral	0.51	disease	0	1	deleterious	0.16	neutral	-2	neutral	0.71	deleterious	-3.58	low_impact	0	medium_impact	0.33	medium_impact	0.64	0.9	1.36	6.61	0.45	N	0.87	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6703	6703	C	G	MI.3585	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	800	267	P	R	cCa/cGa	5.68	1	0	probably_damaging	1	deleterious	0.03	neutral	2.99	neutral	-1.07	deleterious	-3.37	high_impact	3.63	0.51	damaging	0.05	damaging	3.60	23.20	deleterious	0.36	0.55	0.41	neutral	0.79	disease	0.69	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-0.65	medium_impact	2.25	high_impact	0.43	0.9	1.36	6.61	0.43	N	0.90	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6703	6703	C	A	MI.3586	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	800	267	P	Q	cCa/cAa	5.68	1	0	probably_damaging	1	deleterious	0.03	neutral	2.97	neutral	-1.75	deleterious	-2.95	medium_impact	3.29	0.51	damaging	0.04	damaging	4.22	23.90	deleterious	0.29	0.55	0.42	neutral	0.55	disease	0.59	disease	0.69	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.65	medium_impact	1.94	medium_impact	0.46	0.9	1.36	6.61	0.45	N	0.82	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6705	6705	T	C	MI.3587	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	802	268	F	L	Ttt/Ctt	-9.13	0	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.1	deleterious	-4.18	high_impact	4.25	0.57	damaging	0.68	neutral	4.06	23.70	deleterious	0.38	0.55	0.34	neutral	0.85	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.51	0.9	2.14	6.81	0.47	N	0.83	polymorphism	0.88	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6705	6705	T	A	MI.3588	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	802	268	F	I	Ttt/Att	-9.13	0	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-2.81	deleterious	-4.21	high_impact	4.74	0.68	neutral	0.7	neutral	4.42	24.20	deleterious	0.2	0.55	0.28	neutral	0.88	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.28	high_impact	0.43	0.9	2.14	6.81	0.66	P	0.88	polymorphism	0.89	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6705	6705	T	G	MI.3589	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	802	268	F	V	Ttt/Gtt	-9.13	0	0	probably_damaging	1	deleterious	0	neutral	2.66	neutral	-2.28	deleterious	-4.94	high_impact	4.49	0.61	neutral	0.6	neutral	4.13	23.80	deleterious	0.27	0.55	0.43	neutral	0.92	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.05	high_impact	0.34	0.9	2.14	6.81	0.54	N	0.84	polymorphism	0.79	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8695	8695	A	G	MI.359	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	169	57	M	V	Atg/Gtg	3.83	1	0	possibly_damaging	0.87	neutral	0.36	neutral	4.66	neutral	2.87	neutral	-1.6	neutral_impact	-0.46	0.9	neutral	0.53	neutral	2.38	18.71	deleterious	0.55	0.65	0.49	neutral	0.51	disease	0.54	disease	0.5	disease	0	0.88	neutral	0.25	neutral	-3	neutral	0.63	deleterious	-1.54	low_impact	0.15	medium_impact	-1.49	low_impact	0.57	0.9	14.16	15.31	0.4	N	0.95	disease_causing	0.66	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6706	6706	T	G	MI.3590	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	803	268	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-5.29	deleterious	-5.7	high_impact	5.29	0.64	neutral	0.57	neutral	4.14	23.80	deleterious	0.22	0.55	0.83	disease	0.9	disease	0.77	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.25	0.9	2.14	6.81	0.66	P	0.91	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6706	6706	T	C	MI.3591	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	803	268	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.61	deleterious	-3.47	deleterious	-5.69	high_impact	4.59	0.75	neutral	0.73	neutral	4.30	24.00	deleterious	0.25	0.55	0.7	disease	0.89	disease	0.73	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-0.92	medium_impact	3.14	high_impact	0.28	0.9	2.14	6.81	0.56	P	0.84	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6706	6706	T	A	MI.3592	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	803	268	F	Y	tTt/tAt	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.74	neutral	-1.45	neutral	-2.15	high_impact	4.19	0.67	neutral	0.54	neutral	4.33	24.00	deleterious	0.23	0.55	0.75	disease	0.84	disease	0.66	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-0.92	medium_impact	2.77	high_impact	0.58	0.9	2.14	6.81	0.58	P	0.59	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6707	6707	T	A	MI.3593	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	804	268	F	L	ttT/ttA	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.1	deleterious	-4.18	high_impact	4.25	0.57	damaging	0.68	neutral	4.48	24.30	deleterious	0.38	0.55	0.34	neutral	0.85	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.51	0.9	2.14	6.81	0.55	P	0.83	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6707	6707	T	G	MI.3594	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	804	268	F	L	ttT/ttG	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.1	deleterious	-4.18	high_impact	4.25	0.57	damaging	0.68	neutral	4.38	24.10	deleterious	0.38	0.55	0.34	neutral	0.85	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.51	0.9	2.14	6.81	0.54	P	0.83	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6708	6708	G	T	MI.3595	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	805	269	G	W	Gga/Tga	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-6.4	deleterious	-5.88	high_impact	4.95	0.52	damaging	0.15	damaging	4.49	24.30	deleterious	0.16	0.55	0.38	neutral	0.92	disease	0.73	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.36	0.9	3.31	6.76	0.52	P	0.83	disease_causing	0.91	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6708	6708	G	C	MI.3596	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	805	269	G	R	Gga/Cga	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-3.48	deleterious	-5.88	high_impact	5.3	0.51	damaging	0.12	damaging	4.00	23.60	deleterious	0.14	0.55	0.79	disease	0.93	disease	0.77	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.58	0.9	3.31	6.76	0.64	P	0.95	disease_causing	0.87	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6709	6709	G	C	MI.3597	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	806	269	G	A	gGa/gCa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-2.76	deleterious	-4.4	high_impact	4.33	0.66	neutral	0.3	neutral	3.14	22.60	deleterious	0.17	0.55	0.59	disease	0.83	disease	0.63	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.9	high_impact	0.49	0.9	3.31	6.76	0.48	P	0.64	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6709	6709	G	A	MI.3598	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	806	269	G	E	gGa/gAa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-2.98	deleterious	-5.88	high_impact	5.3	0.46	damaging	0.16	damaging	3.88	23.50	deleterious	0.15	0.55	0.72	disease	0.89	disease	0.73	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.49	0.9	3.31	6.76	0.72	P	0.93	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6709	6709	G	T	MI.3599	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	806	269	G	V	gGa/gTa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-4.85	deleterious	-6.61	high_impact	5.3	0.49	damaging	0.16	damaging	3.82	23.40	deleterious	0.14	0.55	0.74	disease	0.94	disease	0.68	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.39	0.9	3.31	6.76	0.62	P	0.93	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8542	8542	T	C	MI.36	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	16	6	F	L	Ttc/Ctc	0.13	0.97	0	probably_damaging	0.92	deleterious	0.01	neutral	4.01	neutral	-0.1	deleterious	-5.08	medium_impact	3.32	0.56	damaging	0.6	neutral	3.90	23.50	deleterious	0.46	0.65	0.61	disease	0.63	disease	0.75	disease	0.75	disease	5	1	deleterious	0.05	neutral	5	deleterious	0.73	deleterious	-1.76	low_impact	-0.84	medium_impact	1.75	medium_impact	0.33	0.9	39.82	8.43	0.43	N	0.89	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8695	8695	A	C	MI.360	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	169	57	M	L	Atg/Ctg	3.83	1	0	possibly_damaging	0.81	neutral	0.96	neutral	4.62	neutral	2.65	neutral	-0.23	neutral_impact	-1.15	0.88	neutral	0.95	neutral	0.33	6.02	deleterious	0.53	0.65	0.45	neutral	0.18	neutral	0.25	neutral	0.28	neutral	4	0.8	neutral	0.58	deleterious	-3	neutral	0.52	deleterious	-1.35	low_impact	1.07	medium_impact	-2.08	low_impact	0.61	0.9	14.16	15.31	0.45	N	0.94	disease_causing	0.61	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6711	6711	T	C	MI.3600	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	808	270	Y	H	Tac/Cac	-12.13	0	0	probably_damaging	1	neutral	0.12	neutral	2.64	neutral	-1.7	neutral	-0.47	low_impact	1.41	0.66	neutral	0.45	neutral	1.97	15.99	deleterious	0.51	0.6	0.69	disease	0.69	disease	0.37	neutral	0.54	disease	1	1	deleterious	0.06	neutral	-2	neutral	0.80	deleterious	-3.58	low_impact	-0.29	medium_impact	0.2	medium_impact	0.32	0.9	2.92	6.77	0.41	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6711	6711	T	G	MI.3601	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	808	270	Y	D	Tac/Gac	-12.13	0	0	probably_damaging	1	neutral	0.05	neutral	2.61	neutral	-2.33	neutral	-0.8	high_impact	3.76	0.65	neutral	0.4	neutral	2.80	21.40	deleterious	0.35	0.55	0.58	disease	0.89	disease	0.64	disease	0.75	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.82	deleterious	-3.58	low_impact	-0.52	medium_impact	2.37	high_impact	0.40	0.9	2.92	6.77	0.42	N	0.98	polymorphism	0.96	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6711	6711	T	A	MI.3602	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	808	270	Y	N	Tac/Aac	-12.13	0	0	probably_damaging	1	neutral	0.16	neutral	2.64	neutral	-1.67	neutral	0.01	neutral_impact	0.72	0.63	neutral	0.68	neutral	2.63	20.40	deleterious	0.4	0.55	0.49	neutral	0.74	disease	0.39	neutral	0.51	disease	0	1	deleterious	0.08	neutral	-2	neutral	0.78	deleterious	-3.58	low_impact	-0.21	medium_impact	-0.43	medium_impact	0.40	0.9	2.92	6.77	0.44	N	0.94	polymorphism	0.95	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6712	6712	A	T	MI.3603	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	809	270	Y	F	tAc/tTc	7.53	1	0	probably_damaging	1	neutral	0.2	neutral	2.6	neutral	-2.62	neutral	-0.61	low_impact	1.75	0.62	neutral	0.44	neutral	1.51	13.37	neutral	0.43	0.55	0.69	disease	0.69	disease	0.3	neutral	0.53	disease	1	1	deleterious	0.1	neutral	-2	neutral	0.81	deleterious	-3.58	low_impact	-0.14	medium_impact	0.52	medium_impact	0.40	0.9	2.92	6.77	0.57	P	0.50	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6712	6712	A	G	MI.3604	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	809	270	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	neutral	0.07	neutral	2.56	deleterious	-5.33	neutral	-0.65	medium_impact	2.71	0.63	neutral	0.66	neutral	2.24	17.76	deleterious	0.32	0.55	0.82	disease	0.87	disease	0.41	neutral	0.65	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.84	deleterious	-3.58	low_impact	-0.43	medium_impact	1.4	medium_impact	0.17	0.9	2.92	6.77	0.5	P	0.89	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6712	6712	A	C	MI.3605	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	809	270	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	neutral	0.32	neutral	2.64	neutral	-1.68	neutral	0.74	neutral_impact	0.03	0.64	neutral	0.67	neutral	2.02	16.34	deleterious	0.31	0.55	0.28	neutral	0.58	disease	0.37	neutral	0.45	neutral	1	1	deleterious	0.16	neutral	-2	neutral	0.73	deleterious	-3.58	low_impact	0.01	medium_impact	-1.07	low_impact	0.36	0.9	2.92	6.77	0.54	P	0.90	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6714	6714	A	G	MI.3606	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	811	271	M	V	Ata/Gta	-3.57	0	0	possibly_damaging	0.79	neutral	0.09	neutral	2.83	neutral	0.95	neutral	-0.8	neutral_impact	0.42	0.53	damaging	0.09	damaging	0.78	9.31	deleterious	0.65	0.7	0.31	neutral	0.8	disease	0.44	neutral	0.52	disease	0	0.94	neutral	0.15	neutral	-3	neutral	0.60	deleterious	-1.3	low_impact	-0.37	medium_impact	-0.71	medium_impact	0.63	0.9	2.14	6.71	0.3	N	0.88	disease_causing	0.51	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6714	6714	A	C	MI.3607	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	811	271	M	L	Ata/Cta	-3.57	0	0	possibly_damaging	0.7	neutral	1	neutral	2.84	neutral	1.22	neutral	1.11	neutral_impact	-2.77	0.57	damaging	0.24	damaging	-1.43	0.00	neutral	0.6	0.65	0.23	neutral	0.35	neutral	0.32	neutral	0.44	neutral	1	0.7	neutral	0.65	deleterious	-3	neutral	0.41	neutral	-1.1	low_impact	1.86	high_impact	-3.66	low_impact	0.61	0.9	2.14	6.71	0.25	N	0.61	polymorphism	0.54	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6714	6714	A	T	MI.3608	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	811	271	M	L	Ata/Tta	-3.57	0	0	possibly_damaging	0.7	neutral	1	neutral	2.84	neutral	1.22	neutral	1.11	neutral_impact	-2.77	0.57	damaging	0.24	damaging	-1.39	0.00	neutral	0.6	0.65	0.23	neutral	0.35	neutral	0.32	neutral	0.44	neutral	1	0.7	neutral	0.65	deleterious	-3	neutral	0.41	neutral	-1.1	low_impact	1.86	high_impact	-3.66	low_impact	0.61	0.9	2.14	6.71	0.25	N	0.61	polymorphism	0.54	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6715	6715	T	C	MI.3609	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	812	271	M	T	aTa/aCa	8.69	1	0	probably_damaging	0.95	neutral	0.13	neutral	2.9	neutral	2.14	neutral	-2.27	neutral_impact	0.01	0.55	damaging	0.19	damaging	1.04	10.88	neutral	0.55	0.6	0.19	neutral	0.77	disease	0.63	disease	0.69	disease	4	0.98	neutral	0.09	neutral	-2	neutral	0.72	deleterious	-1.96	low_impact	-0.27	medium_impact	-1.09	low_impact	0.48	0.9	2.14	6.71	0.44	N	0.79	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8696	8696	T	C	MI.361	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	170	57	M	T	aTg/aCg	-0.1	0.87	0	probably_damaging	0.94	neutral	0.11	neutral	4.45	neutral	1.25	deleterious	-3.61	low_impact	1.18	0.93	neutral	0.67	neutral	2.83	21.50	deleterious	0.34	0.65	0.65	disease	0.57	disease	0.56	disease	0.62	disease	2	0.98	neutral	0.09	neutral	-2	neutral	0.78	deleterious	-1.89	low_impact	-0.22	medium_impact	-0.09	medium_impact	0.34	0.9	14.16	15.31	0.37	N	0.97	polymorphism	0.78	0.06	.	.	.	.	.	pancreatic cancer cell line	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6715	6715	T	A	MI.3610	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	812	271	M	K	aTa/aAa	8.69	1	0	possibly_damaging	0.9	deleterious	0	neutral	3.13	neutral	3.82	deleterious	-2.97	neutral_impact	0.28	0.62	neutral	0.1	damaging	2.12	16.98	deleterious	0.33	0.55	0.16	neutral	0.88	disease	0.71	disease	0.69	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.70	deleterious	-1.65	low_impact	-1.48	low_impact	-0.84	medium_impact	0.63	0.9	2.14	6.71	0.41	N	0.93	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6716	6716	A	C	MI.3611	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	813	271	M	I	atA/atC	5.91	1	0	possibly_damaging	0.85	neutral	0.05	neutral	2.82	neutral	0.47	neutral	-0.14	neutral_impact	-1.04	0.55	damaging	0.12	damaging	1.55	13.57	neutral	0.63	0.65	0.34	neutral	0.69	disease	0.38	neutral	0.48	neutral	0	0.97	neutral	0.1	neutral	-3	neutral	0.64	deleterious	-1.47	low_impact	-0.52	medium_impact	-2.06	low_impact	0.67	0.9	2.14	6.71	0.56	P	0.87	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6716	6716	A	T	MI.3612	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	813	271	M	I	atA/atT	5.91	1	0	possibly_damaging	0.85	neutral	0.05	neutral	2.82	neutral	0.47	neutral	-0.14	neutral_impact	-1.04	0.55	damaging	0.12	damaging	1.68	14.27	neutral	0.63	0.65	0.34	neutral	0.69	disease	0.38	neutral	0.48	neutral	0	0.97	neutral	0.1	neutral	-3	neutral	0.64	deleterious	-1.47	low_impact	-0.52	medium_impact	-2.06	low_impact	0.67	0.9	2.14	6.71	0.57	P	0.87	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6717	6717	G	C	MI.3613	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	814	272	G	R	Ggt/Cgt	-0.1	0.69	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.11	deleterious	-5.54	high_impact	4.83	0.6	neutral	0.19	damaging	3.91	23.50	deleterious	0.14	0.55	0.43	neutral	0.94	disease	0.79	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.36	high_impact	0.80	0.9	2.14	6.69	0.65	P	0.95	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6717	6717	G	T	MI.3614	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	814	272	G	C	Ggt/Tgt	-0.1	0.69	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.53	deleterious	-6.23	high_impact	4.62	0.55	damaging	0.2	damaging	4.12	23.80	deleterious	0.19	0.55	0.71	disease	0.94	disease	0.7	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.75	0.9	2.14	6.69	0.42	N	0.98	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6717	6717	G	A	MI.3615	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	814	272	G	S	Ggt/Agt	-0.1	0.69	0	probably_damaging	1	neutral	0.14	neutral	2.81	neutral	0.07	deleterious	-3.94	medium_impact	2.6	0.46	damaging	0.61	neutral	3.06	22.40	deleterious	0.35	0.55	0.2	neutral	0.86	disease	0.48	neutral	0.16	neutral	7	1	deleterious	0.07	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.25	medium_impact	1.3	medium_impact	0.76	0.9	2.14	6.69	0.45	N	0.73	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6718	6718	G	C	MI.3616	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	815	272	G	A	gGt/gCt	9.15	1	0	probably_damaging	1	neutral	0.08	neutral	2.84	neutral	0.38	deleterious	-4.07	medium_impact	2.98	0.72	neutral	0.38	neutral	3.13	22.60	deleterious	0.35	0.55	0.21	neutral	0.83	disease	0.48	neutral	0.18	neutral	6	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-3.58	low_impact	-0.4	medium_impact	1.65	medium_impact	0.69	0.9	2.14	6.69	0.53	P	0.64	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6718	6718	G	A	MI.3617	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	815	272	G	D	gGt/gAt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.23	deleterious	-4.81	high_impact	5.17	0.57	damaging	0.22	damaging	3.85	23.40	deleterious	0.16	0.55	0.32	neutral	0.93	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.49	0.9	2.14	6.69	0.73	P	0.97	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6718	6718	G	T	MI.3618	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	815	272	G	V	gGt/gTt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.92	neutral	1.17	deleterious	-6.27	high_impact	4.62	0.57	damaging	0.26	damaging	3.77	23.40	deleterious	0.16	0.55	0.27	neutral	0.94	disease	0.69	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.62	0.9	2.14	6.69	0.5	P	0.93	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6720	6720	A	T	MI.3619	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	817	273	M	L	Atg/Ttg	-6.12	0	0	probably_damaging	0.91	neutral	0.06	neutral	2.83	neutral	-0.9	neutral	-2.19	medium_impact	3.12	0.59	damaging	0.07	damaging	3.46	23.00	deleterious	0.49	0.55	0.33	neutral	0.85	disease	0.71	disease	0.72	disease	4	0.98	neutral	0.08	neutral	1	deleterious	0.61	deleterious	-1.7	low_impact	-0.47	medium_impact	1.78	medium_impact	0.52	0.9	3.7	8.28	0.26	N	0.61	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8696	8696	T	A	MI.362	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	170	57	M	K	aTg/aAg	-0.1	0.87	0	probably_damaging	0.94	neutral	0.2	neutral	4.37	neutral	-0.91	deleterious	-4.34	medium_impact	2.52	0.84	neutral	0.36	neutral	4.04	23.70	deleterious	0.15	0.65	0.72	disease	0.75	disease	0.68	disease	0.71	disease	4	0.96	neutral	0.13	neutral	1	deleterious	0.82	deleterious	-1.89	low_impact	-0.05	medium_impact	1.06	medium_impact	0.56	0.9	14.16	15.31	0.28	N	0.99	disease_causing	0.68	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6720	6720	A	G	MI.3620	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	817	273	M	V	Atg/Gtg	-6.12	0	0	probably_damaging	0.94	deleterious	0	neutral	2.73	neutral	-0.91	deleterious	-2.92	high_impact	3.79	0.5	damaging	0.12	damaging	2.81	21.40	deleterious	0.45	0.55	0.36	neutral	0.9	disease	0.7	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.73	deleterious	-1.88	low_impact	-1.48	low_impact	2.4	high_impact	0.46	0.9	3.7	8.28	0.33	N	0.88	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6720	6720	A	C	MI.3621	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	817	273	M	L	Atg/Ctg	-6.12	0	0	probably_damaging	0.91	neutral	0.06	neutral	2.83	neutral	-0.9	neutral	-2.19	medium_impact	3.12	0.59	damaging	0.07	damaging	3.42	23.00	deleterious	0.49	0.55	0.33	neutral	0.85	disease	0.71	disease	0.72	disease	4	0.98	neutral	0.08	neutral	1	deleterious	0.61	deleterious	-1.7	low_impact	-0.47	medium_impact	1.78	medium_impact	0.52	0.9	3.7	8.28	0.26	N	0.61	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6721	6721	T	C	MI.3622	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	818	273	M	T	aTg/aCg	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.64	neutral	-2.34	deleterious	-4.37	high_impact	5.24	0.61	neutral	0.1	damaging	3.03	22.30	deleterious	0.36	0.55	0.46	neutral	0.91	disease	0.74	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.64	low_impact	-1.48	low_impact	3.74	high_impact	0.40	0.9	3.7	8.28	0.72	P	0.79	disease_causing_automatic	1	0.22	rs199476127	Pathogenic	Sideroblastic_anemia,_acquired_idiopathic	24704	MedGen:C4016601	bone marrow, whole blood, platelets, granulocytes	.	.	.	T6721C	Acquired Idiopathic Sideroblastic Anemia	-	+	Reported	2	P	P	P	damaging
chrM	6721	6721	T	A	MI.3623	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	818	273	M	K	aTg/aAg	8.69	1	0	probably_damaging	0.97	deleterious	0	neutral	2.59	deleterious	-3.52	deleterious	-4.37	high_impact	4.88	0.54	damaging	0.08	damaging	3.93	23.50	deleterious	0.2	0.55	0.66	disease	0.93	disease	0.77	disease	0.8	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-2.18	low_impact	-1.48	low_impact	3.41	high_impact	0.37	0.9	3.7	8.28	0.71	P	0.93	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6722	6722	G	T	MI.3624	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	819	273	M	I	atG/atT	4.76	1	0	probably_damaging	0.96	deleterious	0	neutral	2.69	neutral	-1.3	deleterious	-2.92	high_impact	3.88	0.52	damaging	0.1	damaging	3.72	23.30	deleterious	0.4	0.55	0.29	neutral	0.91	disease	0.69	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.76	deleterious	-2.06	low_impact	-1.48	low_impact	2.48	high_impact	0.61	0.9	3.7	8.28	0.43	N	0.87	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6722	6722	G	C	MI.3625	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	819	273	M	I	atG/atC	4.76	1	0	probably_damaging	0.96	deleterious	0	neutral	2.69	neutral	-1.3	deleterious	-2.92	high_impact	3.88	0.52	damaging	0.1	damaging	3.61	23.20	deleterious	0.4	0.55	0.29	neutral	0.91	disease	0.69	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.76	deleterious	-2.06	low_impact	-1.48	low_impact	2.48	high_impact	0.61	0.9	3.7	8.28	0.42	N	0.87	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6723	6723	G	C	MI.3626	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	820	274	V	L	Gtc/Ctc	0.36	0.97	0	benign	0.09	deleterious	0.01	neutral	2.69	neutral	-1.48	neutral	-1.02	medium_impact	2.52	0.6	neutral	0.51	neutral	1.71	14.49	neutral	0.33	0.55	0.35	neutral	0.78	disease	0.49	neutral	0.6	disease	2	0.99	deleterious	0.46	neutral	1	deleterious	0.31	neutral	0.19	medium_impact	-0.92	medium_impact	1.23	medium_impact	0.73	0.9	3.9	9.77	0.45	N	0.55	disease_causing	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6723	6723	G	T	MI.3627	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	820	274	V	F	Gtc/Ttc	0.36	0.97	0	possibly_damaging	0.89	deleterious	0	neutral	2.58	neutral	-2.96	neutral	-2.46	medium_impact	3.02	0.58	damaging	0.48	neutral	3.75	23.30	deleterious	0.16	0.55	0.63	disease	0.9	disease	0.46	neutral	0.73	disease	5	1	deleterious	0.06	neutral	4	deleterious	0.79	deleterious	-1.61	low_impact	-1.48	low_impact	1.69	medium_impact	0.64	0.9	3.9	9.77	0.43	N	0.86	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6723	6723	G	A	MI.3628	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	820	274	V	I	Gtc/Atc	0.36	0.97	0	benign	0.09	neutral	0.66	neutral	2.68	neutral	-1.03	neutral	0.41	neutral_impact	-1.21	0.65	neutral	0.71	neutral	-0.94	0.02	neutral	0.39	0.55	0.24	neutral	0.16	neutral	0.17	neutral	0.27	neutral	5	0.24	neutral	0.79	deleterious	-6	neutral	0.16	neutral	0.19	medium_impact	0.35	medium_impact	-2.22	low_impact	0.78	0.9	3.9	9.77	0.41	N	0.24	disease_causing	0.94	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6724	6724	T	A	MI.3629	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	821	274	V	D	gTc/gAc	6.14	1	0	probably_damaging	0.91	deleterious	0	neutral	2.53	deleterious	-5.15	deleterious	-4.46	high_impact	3.72	0.6	damaging	0.48	neutral	4.49	24.30	deleterious	0.07	0.55	0.86	disease	0.91	disease	0.64	disease	0.8	disease	6	1	deleterious	0.05	neutral	6	deleterious	0.85	deleterious	-1.7	low_impact	-1.48	low_impact	2.34	high_impact	0.59	0.9	3.9	9.77	0.41	N	0.83	disease_causing	1	0.37	rs28393263	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8697	8697	G	C	MI.363	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	171	57	M	I	atG/atC	7.53	0.99	0.1	probably_damaging	0.91	neutral	0.41	neutral	4.63	neutral	2.75	neutral	-1.08	neutral_impact	-0.34	0.84	neutral	0.73	neutral	1.96	15.94	deleterious	0.59	0.7	0.38	neutral	0.34	neutral	0.29	neutral	0.47	neutral	1	0.91	neutral	0.25	neutral	-2	neutral	0.64	deleterious	-1.71	low_impact	0.2	medium_impact	-1.39	low_impact	0.68	0.9	14.16	15.31	0.47	N	0.92	disease_causing	0.67	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6724	6724	T	C	MI.3630	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	821	274	V	A	gTc/gCc	6.14	1	0	benign	0.41	deleterious	0.02	neutral	2.64	neutral	-1.57	deleterious	-2.86	medium_impact	2.15	0.62	neutral	0.62	neutral	3.10	22.50	deleterious	0.26	0.55	0.29	neutral	0.66	disease	0.34	neutral	0.46	neutral	1	0.98	neutral	0.31	neutral	1	deleterious	0.39	neutral	-0.61	medium_impact	-0.75	medium_impact	0.89	medium_impact	0.55	0.9	3.9	9.77	0.51	P	0.47	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6724	6724	T	G	MI.3631	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	821	274	V	G	gTc/gGc	6.14	1	0	possibly_damaging	0.9	deleterious	0.02	neutral	2.54	deleterious	-4.36	deleterious	-5.04	medium_impact	3.17	0.6	damaging	0.59	neutral	3.81	23.40	deleterious	0.14	0.55	0.77	disease	0.82	disease	0.53	disease	0.73	disease	5	0.99	deleterious	0.06	neutral	4	deleterious	0.78	deleterious	-1.65	low_impact	-0.75	medium_impact	1.83	medium_impact	0.55	0.9	3.9	9.77	0.48	N	0.71	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6726	6726	T	C	MI.3632	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	823	275	W	R	Tga/Cga	-12.6	0	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-1.67	deleterious	-3.64	low_impact	1.84	0.5	damaging	0.05	damaging	3.59	23.20	deleterious	0.34	0.55	0.49	neutral	0.92	disease	0.67	disease	0.81	disease	6	1	deleterious	0	neutral	2	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	0.6	medium_impact	0.49	0.9	5.07	8.67	0.25	N	0.98	polymorphism	0.98	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6726	6726	T	G	MI.3633	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	823	275	W	G	Tga/Gga	-12.6	0	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-1.71	deleterious	-4.22	neutral_impact	0.32	0.54	damaging	0.07	damaging	3.87	23.50	deleterious	0.31	0.55	0.27	neutral	0.77	disease	0.63	disease	0.74	disease	5	1	deleterious	0	neutral	2	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	-0.8	medium_impact	0.44	0.9	5.07	8.67	0.26	N	0.89	polymorphism	0.95	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6727	6727	G	C	MI.3634	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	824	275	W	S	tGa/tCa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	0.29	deleterious	-3.63	low_impact	0.87	0.48	damaging	0.05	damaging	4.04	23.70	deleterious	0.3	0.55	0.31	neutral	0.8	disease	0.61	disease	0.74	disease	5	1	deleterious	0	neutral	2	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	-0.3	medium_impact	0.43	0.9	5.07	8.67	0.4	N	0.89	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6727	6727	G	T	MI.3635	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	824	275	W	L	tGa/tTa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	3.04	neutral	2.25	deleterious	-2.91	neutral_impact	0.2	0.54	damaging	0.04	damaging	4.30	24.00	deleterious	0.29	0.55	0.16	neutral	0.77	disease	0.59	disease	0.73	disease	5	1	deleterious	0	neutral	2	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	-0.91	medium_impact	0.37	0.9	5.07	8.67	0.37	N	0.95	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6728	6728	A	T	MI.3636	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	825	275	W	C	tgA/tgT	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-0.74	deleterious	-3.57	neutral_impact	0.6	0.52	damaging	0.05	damaging	4.16	23.80	deleterious	0.36	0.55	0.45	neutral	0.87	disease	0.58	disease	0.73	disease	5	1	deleterious	0	neutral	2	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	-0.55	medium_impact	0.57	0.9	5.07	8.67	0.37	N	0.88	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6728	6728	A	C	MI.3637	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	825	275	W	C	tgA/tgC	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-0.74	deleterious	-3.57	neutral_impact	0.6	0.52	damaging	0.05	damaging	4.06	23.70	deleterious	0.36	0.55	0.45	neutral	0.87	disease	0.58	disease	0.73	disease	5	1	deleterious	0	neutral	2	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	-0.55	medium_impact	0.57	0.9	5.07	8.67	0.37	N	0.88	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6729	6729	G	T	MI.3638	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	826	276	A	S	Gct/Tct	-0.1	0.84	0	probably_damaging	0.99	deleterious	0	neutral	2.69	neutral	-1.63	neutral	-2.18	medium_impact	3.49	0.68	neutral	0.15	damaging	3.73	23.30	deleterious	0.2	0.55	0.28	neutral	0.76	disease	0.56	disease	0.65	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.12	high_impact	0.84	0.9	4.09	8.37	0.3	N	0.64	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6729	6729	G	A	MI.3639	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	826	276	A	T	Gct/Act	-0.1	0.84	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.11	deleterious	-2.91	high_impact	5.28	0.46	damaging	0.18	damaging	4.22	23.90	deleterious	0.27	0.55	0.61	disease	0.81	disease	0.59	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.73	0.9	4.09	8.37	0.65	P	0.20	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8697	8697	G	T	MI.364	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	171	57	M	I	atG/atT	7.53	0.99	0.1	probably_damaging	0.91	neutral	0.41	neutral	4.63	neutral	2.75	neutral	-1.08	neutral_impact	-0.34	0.84	neutral	0.73	neutral	2.11	16.91	deleterious	0.59	0.7	0.38	neutral	0.34	neutral	0.29	neutral	0.47	neutral	1	0.91	neutral	0.25	neutral	-2	neutral	0.64	deleterious	-1.71	low_impact	0.2	medium_impact	-1.39	low_impact	0.68	0.9	14.16	15.31	0.47	N	0.92	disease_causing	0.67	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6729	6729	G	C	MI.3640	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	826	276	A	P	Gct/Cct	-0.1	0.84	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.32	deleterious	-3.65	high_impact	5.28	0.52	damaging	0.15	damaging	3.87	23.50	deleterious	0.11	0.55	0.81	disease	0.83	disease	0.76	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.74	0.9	4.09	8.37	0.66	P	0.85	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6730	6730	C	A	MI.3641	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	827	276	A	D	gCt/gAt	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-3.49	deleterious	-4.38	high_impact	5.28	0.59	damaging	0.12	damaging	4.59	24.40	deleterious	0.08	0.55	0.76	disease	0.88	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.70	0.9	4.09	8.37	0.75	P	0.89	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6730	6730	C	G	MI.3642	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	827	276	A	G	gCt/gGt	5.22	1	0	probably_damaging	0.98	deleterious	0	neutral	2.61	neutral	-2.47	deleterious	-2.92	high_impact	4.48	0.59	damaging	0.15	damaging	3.95	23.60	deleterious	0.15	0.55	0.7	disease	0.71	disease	0.63	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.35	low_impact	-1.48	low_impact	3.04	high_impact	0.80	0.9	4.09	8.37	0.51	P	0.56	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6730	6730	C	T	MI.3643	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	827	276	A	V	gCt/gTt	5.22	1	0	probably_damaging	0.99	deleterious	0	neutral	2.59	neutral	-2.79	deleterious	-2.92	high_impact	4.93	0.53	damaging	0.12	damaging	4.40	24.10	deleterious	0.28	0.55	0.74	disease	0.86	disease	0.65	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.45	high_impact	0.71	0.9	4.09	8.37	0.75	P	0.75	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6732	6732	A	C	MI.3644	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	829	277	M	L	Atg/Ctg	-10.51	0	0	probably_damaging	0.91	deleterious	0.01	neutral	2.79	neutral	-0.16	neutral	-2.08	high_impact	3.56	0.62	neutral	0.05	damaging	3.42	23.00	deleterious	0.44	0.55	0.24	neutral	0.89	disease	0.6	disease	0.65	disease	3	1	deleterious	0.05	neutral	6	deleterious	0.69	deleterious	-1.7	low_impact	-0.92	medium_impact	2.19	high_impact	0.63	0.9	2.53	6.72	0.27	N	0.61	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6732	6732	A	G	MI.3645	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	829	277	M	V	Atg/Gtg	-10.51	0	0	probably_damaging	0.94	deleterious	0	neutral	2.78	neutral	-0.21	deleterious	-2.77	high_impact	4.11	0.56	damaging	0.08	damaging	2.82	21.50	deleterious	0.48	0.55	0.29	neutral	0.93	disease	0.63	disease	0.73	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.77	deleterious	-1.88	low_impact	-1.48	low_impact	2.7	high_impact	0.64	0.9	2.53	6.72	0.29	N	0.88	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6732	6732	A	T	MI.3646	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	829	277	M	L	Atg/Ttg	-10.51	0	0	probably_damaging	0.91	deleterious	0.01	neutral	2.79	neutral	-0.16	neutral	-2.08	high_impact	3.56	0.62	neutral	0.05	damaging	3.48	23.10	deleterious	0.44	0.55	0.24	neutral	0.89	disease	0.6	disease	0.65	disease	3	1	deleterious	0.05	neutral	6	deleterious	0.69	deleterious	-1.7	low_impact	-0.92	medium_impact	2.19	high_impact	0.63	0.9	2.53	6.72	0.27	N	0.61	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6733	6733	T	C	MI.3647	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	830	277	M	T	aTg/aCg	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.77	neutral	-0.32	deleterious	-4.24	medium_impact	3.04	0.58	damaging	0.09	damaging	3.00	22.20	deleterious	0.36	0.55	0.3	neutral	0.92	disease	0.67	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-2.64	low_impact	-1.48	low_impact	1.71	medium_impact	0.41	0.9	2.53	6.72	0.39	N	0.79	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6733	6733	T	A	MI.3648	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	830	277	M	K	aTg/aAg	8.69	1	0	probably_damaging	0.97	deleterious	0	neutral	2.65	deleterious	-3.04	deleterious	-4.29	high_impact	5.14	0.55	damaging	0.06	damaging	3.93	23.50	deleterious	0.23	0.55	0.55	disease	0.95	disease	0.74	disease	0.85	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.18	low_impact	-1.48	low_impact	3.65	high_impact	0.51	0.9	2.53	6.72	0.69	P	0.93	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6734	6734	G	C	MI.3649	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	831	277	M	I	atG/atC	7.53	1	0.02	probably_damaging	0.96	neutral	0.11	neutral	2.84	neutral	0.27	deleterious	-2.75	medium_impact	2.5	0.51	damaging	0.13	damaging	3.57	23.10	deleterious	0.43	0.55	0.24	neutral	0.92	disease	0.5	neutral	0.47	neutral	1	0.98	deleterious	0.08	neutral	1	deleterious	0.79	deleterious	-2.06	low_impact	-0.31	medium_impact	1.21	medium_impact	0.73	0.9	2.53	6.72	0.45	N	0.87	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8698	8698	A	T	MI.365	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	172	58	M	L	Ata/Tta	-1.03	0	0	possibly_damaging	0.81	neutral	0.67	neutral	4.38	neutral	-0.22	neutral	-1.32	neutral_impact	0.19	0.9	neutral	0.98	neutral	1.03	10.84	neutral	0.69	0.75	NA	NA	0.3	neutral	0.25	neutral	0.2	neutral	6	0.77	neutral	0.43	neutral	-3	neutral	0.56	deleterious	-1.35	low_impact	0.47	medium_impact	-0.94	medium_impact	0.58	0.9	40.71	8.78	0.33	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6734	6734	G	T	MI.3650	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	831	277	M	I	atG/atT	7.53	1	0.02	probably_damaging	0.96	neutral	0.11	neutral	2.84	neutral	0.27	deleterious	-2.75	medium_impact	2.5	0.51	damaging	0.13	damaging	3.69	23.30	deleterious	0.43	0.55	0.24	neutral	0.92	disease	0.5	neutral	0.47	neutral	1	0.98	deleterious	0.08	neutral	1	deleterious	0.79	deleterious	-2.06	low_impact	-0.31	medium_impact	1.21	medium_impact	0.73	0.9	2.53	6.72	0.46	N	0.87	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6735	6735	A	G	MI.3651	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	832	278	M	V	Ata/Gta	-1.03	0	0	benign	0	neutral	0.21	neutral	2.97	neutral	1.83	neutral	-0.3	neutral_impact	0.26	0.79	neutral	0.95	neutral	-0.51	0.21	neutral	0.52	0.6	0.19	neutral	0.75	disease	0.27	neutral	0.41	neutral	2	0.79	neutral	0.61	deleterious	-6	neutral	0.19	neutral	2.07	high_impact	-0.13	medium_impact	-0.86	medium_impact	0.62	0.9	9.36	31.7	0.36	N	0.01	polymorphism	0.65	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6735	6735	A	T	MI.3652	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	832	278	M	L	Ata/Tta	-1.03	0	0	benign	0	neutral	0.78	neutral	2.98	neutral	1.88	neutral	-0.01	neutral_impact	-0.58	0.63	neutral	0.72	neutral	-1.20	0.01	neutral	0.47	0.55	0.18	neutral	0.62	disease	0.25	neutral	0.39	neutral	2	0.21	neutral	0.89	deleterious	-6	neutral	0.18	neutral	2.07	high_impact	0.5	medium_impact	-1.64	low_impact	0.62	0.9	9.36	31.7	0.38	N	0.40	polymorphism	0.7	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6735	6735	A	C	MI.3653	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	832	278	M	L	Ata/Cta	-1.03	0	0	benign	0	neutral	0.78	neutral	2.98	neutral	1.88	neutral	-0.01	neutral_impact	-0.58	0.63	neutral	0.72	neutral	-1.27	0.01	neutral	0.47	0.55	0.18	neutral	0.62	disease	0.25	neutral	0.39	neutral	2	0.21	neutral	0.89	deleterious	-6	neutral	0.18	neutral	2.07	high_impact	0.5	medium_impact	-1.64	low_impact	0.62	0.9	9.36	31.7	0.37	N	0.40	polymorphism	0.7	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6736	6736	T	C	MI.3654	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	833	278	M	T	aTa/aCa	3.14	0.99	0	benign	0.05	deleterious	0.02	neutral	2.81	neutral	0.14	neutral	-1.88	low_impact	1.23	0.64	neutral	0.53	neutral	0.03	2.84	deleterious	0.33	0.55	0.32	neutral	0.82	disease	0.35	neutral	0.45	neutral	1	0.98	neutral	0.49	deleterious	-2	neutral	0.27	neutral	0.45	medium_impact	-0.75	medium_impact	0.04	medium_impact	0.50	0.9	9.36	31.7	0.47	N	0.68	disease_causing	0.92	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6736	6736	T	A	MI.3655	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	833	278	M	K	aTa/aAa	3.14	0.99	0	benign	0.05	deleterious	0	neutral	2.76	neutral	-1.58	deleterious	-2.68	medium_impact	3.12	0.64	neutral	0.38	neutral	2.13	17.06	deleterious	0.15	0.55	0.51	disease	0.94	disease	0.6	disease	0.82	disease	6	1	deleterious	0.48	deleterious	1	deleterious	0.33	neutral	0.45	medium_impact	-1.48	low_impact	1.78	medium_impact	0.60	0.9	9.36	31.7	0.45	N	0.83	disease_causing	0.99	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6737	6737	A	C	MI.3656	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	834	278	M	I	atA/atC	7.53	1	0.01	benign	0	neutral	0.39	neutral	2.97	neutral	1.78	neutral	-0.16	neutral_impact	-0.16	0.74	neutral	0.78	neutral	0.07	3.24	deleterious	0.47	0.55	0.17	neutral	0.79	disease	0.25	neutral	0.42	neutral	2	0.61	neutral	0.7	deleterious	-6	neutral	0.21	neutral	2.07	high_impact	0.09	medium_impact	-1.25	low_impact	0.68	0.9	9.36	31.7	0.51	P	0.50	disease_causing	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6737	6737	A	T	MI.3657	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	834	278	M	I	atA/atT	7.53	1	0.01	benign	0	neutral	0.39	neutral	2.97	neutral	1.78	neutral	-0.16	neutral_impact	-0.16	0.74	neutral	0.78	neutral	0.13	3.93	deleterious	0.47	0.55	0.17	neutral	0.79	disease	0.25	neutral	0.42	neutral	2	0.61	neutral	0.7	deleterious	-6	neutral	0.21	neutral	2.07	high_impact	0.09	medium_impact	-1.25	low_impact	0.68	0.9	9.36	31.7	0.51	P	0.50	disease_causing	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6738	6738	T	C	MI.3658	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	835	279	S	P	Tca/Cca	-0.33	0.18	0	probably_damaging	1	deleterious	0.01	neutral	2.65	deleterious	-3.52	neutral	-1.84	high_impact	3.76	0.41	damaging	0.06	damaging	4.00	23.60	deleterious	0.13	0.55	0.6	disease	0.96	disease	0.65	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-0.92	medium_impact	2.37	high_impact	0.71	0.9	1.56	6.63	0.46	N	0.91	disease_causing	0.78	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6738	6738	T	G	MI.3659	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	835	279	S	A	Tca/Gca	-0.33	0.18	0	probably_damaging	0.99	neutral	0.88	neutral	2.89	neutral	0.58	neutral	0.58	neutral_impact	-0.06	0.61	neutral	0.41	neutral	0.99	10.63	neutral	0.38	0.55	0.19	neutral	0.38	neutral	0.26	neutral	0.44	neutral	1	0.99	deleterious	0.45	neutral	-2	neutral	0.64	deleterious	-2.64	low_impact	0.67	medium_impact	-1.15	low_impact	0.78	0.9	1.56	6.63	0.27	N	0.35	polymorphism	0.85	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8698	8698	A	C	MI.366	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	172	58	M	L	Ata/Cta	-1.03	0	0	possibly_damaging	0.81	neutral	0.67	neutral	4.38	neutral	-0.22	neutral	-1.32	neutral_impact	0.19	0.9	neutral	0.98	neutral	0.96	10.44	neutral	0.69	0.75	NA	NA	0.3	neutral	0.25	neutral	0.2	neutral	6	0.77	neutral	0.43	neutral	-3	neutral	0.56	deleterious	-1.35	low_impact	0.47	medium_impact	-0.94	medium_impact	0.58	0.9	40.71	8.78	0.33	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6738	6738	T	A	MI.3660	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	835	279	S	T	Tca/Aca	-0.33	0.18	0	probably_damaging	0.98	neutral	0.15	neutral	2.76	neutral	-0.44	neutral	-0.6	low_impact	1.07	0.52	damaging	0.12	damaging	2.58	19.96	deleterious	0.25	0.55	0.37	neutral	0.77	disease	0.31	neutral	0.43	neutral	1	0.99	deleterious	0.09	neutral	-2	neutral	0.75	deleterious	-2.35	low_impact	-0.23	medium_impact	-0.11	medium_impact	0.87	0.9	1.56	6.63	0.35	N	0.43	polymorphism	0.64	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6739	6739	C	G	MI.3661	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	836	279	S	W	tCa/tGa	5.91	1	0	probably_damaging	1	neutral	0.08	neutral	2.65	deleterious	-3.74	deleterious	-2.92	high_impact	3.96	0.44	damaging	0.05	damaging	4.30	24.00	deleterious	0.13	0.55	0.8	disease	0.97	disease	0.58	disease	0.78	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.86	deleterious	-3.58	low_impact	-0.4	medium_impact	2.56	high_impact	0.49	0.9	1.56	6.63	0.53	P	0.94	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6739	6739	C	T	MI.3662	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	836	279	S	L	tCa/tTa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.9	neutral	0.67	neutral	-2.25	medium_impact	3.27	0.46	damaging	0.05	damaging	4.62	24.50	deleterious	0.17	0.55	0.28	neutral	0.95	disease	0.49	neutral	0.76	disease	5	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	1.92	medium_impact	0.90	0.95	1.56	6.63	0.5	P	0.90	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6741	6741	A	C	MI.3663	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	838	280	I	L	Att/Ctt	-13.75	0	0	probably_damaging	0.98	deleterious	0	neutral	2.66	neutral	-1.57	neutral	-1.45	high_impact	4.61	0.65	neutral	0.09	damaging	3.83	23.40	deleterious	0.3	0.55	0.5	neutral	0.62	disease	0.6	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.67	deleterious	-2.35	low_impact	-1.48	low_impact	3.16	high_impact	0.67	0.9	3.7	8.34	0.4	N	0.61	polymorphism	0.97	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6741	6741	A	T	MI.3664	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	838	280	I	F	Att/Ttt	-13.75	0	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.91	deleterious	-2.9	high_impact	5.29	0.6	damaging	0.07	damaging	4.03	23.60	deleterious	0.23	0.55	0.7	disease	0.78	disease	0.64	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.70	0.9	3.7	8.34	0.61	P	0.85	disease_causing	0.76	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6741	6741	A	G	MI.3665	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	838	280	I	V	Att/Gtt	-13.75	0	0	probably_damaging	0.95	deleterious	0.01	neutral	2.5	neutral	-2.18	neutral	-0.72	high_impact	4.61	0.63	neutral	0.12	damaging	3.05	22.40	deleterious	0.4	0.55	0.5	neutral	0.53	disease	0.57	disease	0.63	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.64	deleterious	-1.96	low_impact	-0.92	medium_impact	3.16	high_impact	0.54	0.9	3.7	8.34	0.43	N	0.23	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6742	6742	T	C	MI.3666	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	839	280	I	T	aTt/aCt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.79	deleterious	-3.62	high_impact	4.75	0.6	neutral	0.09	damaging	3.45	23.00	deleterious	0.33	0.55	0.52	disease	0.7	disease	0.63	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.49	0.9	3.7	8.34	0.63	P	0.76	disease_causing_automatic	1	0.26	rs199476126	Pathogenic	Sideroblastic_anemia,_acquired_idiopathic	24703	MedGen:C4016601	bone marrow, whole blood, platelets,  granulocytes	.	.	.	T6742C	Acquired Idiopathic Sideroblastic Anemia	-	+	Reported	2	P	P	P	damaging
chrM	6742	6742	T	A	MI.3667	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	839	280	I	N	aTt/aAt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.39	deleterious	-5.66	deleterious	-5.08	high_impact	4.95	0.57	damaging	0.09	damaging	4.49	24.30	deleterious	0.19	0.55	0.75	disease	0.78	disease	0.66	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.46	0.9	3.7	8.34	0.66	P	0.94	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6742	6742	T	G	MI.3668	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	839	280	I	S	aTt/aGt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.54	deleterious	-4.35	high_impact	5.29	0.61	neutral	0.14	damaging	4.31	24.00	deleterious	0.21	0.55	0.64	disease	0.79	disease	0.63	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.37	0.9	3.7	8.34	0.7	P	0.62	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6743	6743	T	A	MI.3669	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	840	280	I	M	atT/atA	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-4.39	neutral	-2.18	high_impact	4.5	0.63	neutral	0.09	damaging	3.71	23.30	deleterious	0.28	0.55	0.56	disease	0.63	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.73	0.9	3.7	8.34	0.49	P	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8698	8698	A	G	MI.367	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	172	58	M	V	Ata/Gta	-1.03	0	0	possibly_damaging	0.87	neutral	0.5	neutral	4.44	neutral	0.94	deleterious	-2.58	low_impact	1.57	0.81	neutral	0.51	neutral	2.56	19.85	deleterious	0.74	0.8	NA	NA	0.58	disease	0.47	neutral	0.47	neutral	1	0.86	neutral	0.32	neutral	-3	neutral	0.66	deleterious	-1.54	low_impact	0.29	medium_impact	0.25	medium_impact	0.48	0.9	40.71	8.78	0.23	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6743	6743	T	G	MI.3670	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	840	280	I	M	atT/atG	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-4.39	neutral	-2.18	high_impact	4.5	0.63	neutral	0.09	damaging	3.45	23.00	deleterious	0.28	0.55	0.56	disease	0.63	disease	0.64	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.73	0.9	3.7	8.34	0.48	P	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6744	6744	G	T	MI.3671	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	841	281	G	C	Ggc/Tgc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-2.41	deleterious	-6.24	high_impact	4.32	0.37	damaging	0.01	damaging	4.12	23.80	deleterious	0.18	0.55	0.72	disease	0.94	disease	0.61	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.89	high_impact	0.64	0.9	2.73	6.68	0.45	N	0.98	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6744	6744	G	C	MI.3672	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	841	281	G	R	Ggc/Cgc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-2.55	deleterious	-5.55	high_impact	4.43	0.43	damaging	0.01	damaging	3.90	23.50	deleterious	0.11	0.55	0.56	disease	0.95	disease	0.73	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.99	high_impact	0.74	0.9	2.73	6.68	0.47	N	0.95	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6744	6744	G	A	MI.3673	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	841	281	G	S	Ggc/Agc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-0.64	deleterious	-4.09	medium_impact	3.37	0.45	damaging	0.03	damaging	4.16	23.80	deleterious	0.21	0.55	0.29	neutral	0.87	disease	0.5	neutral	0.5	disease	0	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.01	high_impact	0.73	0.9	2.73	6.68	0.35	N	0.73	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6745	6745	G	A	MI.3674	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	842	281	G	D	gGc/gAc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.5	deleterious	-4.86	high_impact	5.12	0.32	damaging	0.01	damaging	3.82	23.40	deleterious	0.14	0.55	0.63	disease	0.93	disease	0.72	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.58	0.9	2.73	6.68	0.74	P	0.97	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6745	6745	G	T	MI.3675	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	842	281	G	V	gGc/gTc	6.14	1	0	probably_damaging	1	neutral	0.06	neutral	2.81	neutral	0.08	deleterious	-6.22	high_impact	3.63	0.46	damaging	0.02	damaging	3.79	23.40	deleterious	0.15	0.55	0.31	neutral	0.94	disease	0.59	disease	0.74	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.80	deleterious	-3.58	low_impact	-0.47	medium_impact	2.25	high_impact	0.51	0.9	2.73	6.68	0.46	N	0.93	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6745	6745	G	C	MI.3676	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	842	281	G	A	gGc/gCc	6.14	1	0	probably_damaging	1	neutral	0.11	neutral	3	neutral	1.36	deleterious	-4.09	medium_impact	2.12	0.43	damaging	0.13	damaging	3.04	22.40	deleterious	0.3	0.55	0.2	neutral	0.81	disease	0.38	neutral	0.21	neutral	6	1	deleterious	0.06	neutral	1	deleterious	0.74	deleterious	-3.58	low_impact	-0.31	medium_impact	0.86	medium_impact	0.74	0.9	2.73	6.68	0.55	P	0.64	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6747	6747	T	C	MI.3677	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	844	282	F	L	Ttc/Ctc	-20	0	0	probably_damaging	0.96	neutral	1	neutral	2.86	neutral	-0.47	neutral	0.99	neutral_impact	-0.94	0.62	neutral	0.43	neutral	-0.53	0.18	neutral	0.27	0.55	0.17	neutral	0.35	neutral	0.25	neutral	0.45	neutral	1	0.96	neutral	0.52	deleterious	-2	neutral	0.65	deleterious	-2.06	low_impact	1.86	high_impact	-1.97	low_impact	0.75	0.9	2.53	7.37	0.27	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6747	6747	T	A	MI.3678	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	844	282	F	I	Ttc/Atc	-20	0	0	probably_damaging	0.98	neutral	0.37	neutral	2.76	neutral	-0.63	neutral	0.79	neutral_impact	-0.48	0.64	neutral	0.22	damaging	0.94	10.33	neutral	0.22	0.55	0.31	neutral	0.65	disease	0.25	neutral	0.36	neutral	3	0.98	neutral	0.2	neutral	-2	neutral	0.71	deleterious	-2.35	low_impact	0.06	medium_impact	-1.54	low_impact	0.59	0.9	2.53	7.37	0.32	N	0.88	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6747	6747	T	G	MI.3679	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	844	282	F	V	Ttc/Gtc	-20	0	0	probably_damaging	0.99	neutral	0.3	neutral	2.81	neutral	-0.26	neutral	0.39	neutral_impact	-0.04	0.7	neutral	0.26	damaging	0.98	10.53	neutral	0.28	0.55	0.21	neutral	0.69	disease	0.25	neutral	0.35	neutral	3	0.99	deleterious	0.16	neutral	-2	neutral	0.69	deleterious	-2.64	low_impact	-0.01	medium_impact	-1.14	low_impact	0.59	0.9	2.53	7.37	0.34	N	0.84	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8699	8699	T	A	MI.368	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	173	58	M	K	aTa/aAa	0.36	0.03	0	probably_damaging	0.94	neutral	0.33	neutral	4.62	neutral	2.41	deleterious	-4.64	neutral_impact	0.69	0.77	neutral	0.41	neutral	3.83	23.40	deleterious	0.35	0.65	NA	NA	0.73	disease	0.4	neutral	0.52	disease	0	0.95	neutral	0.2	neutral	-2	neutral	0.79	deleterious	-1.89	low_impact	0.12	medium_impact	-0.51	medium_impact	0.59	0.9	40.71	8.78	0.27	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6748	6748	T	A	MI.3680	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	845	282	F	Y	tTc/tAc	4.29	1	0	probably_damaging	0.96	deleterious	0	neutral	2.62	neutral	-2.9	neutral	-0.76	medium_impact	2.63	0.63	neutral	0.11	damaging	2.46	19.24	deleterious	0.26	0.55	0.41	neutral	0.78	disease	0.46	neutral	0.61	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-2.06	low_impact	-1.48	low_impact	1.33	medium_impact	0.62	0.9	2.53	7.37	0.46	N	0.59	disease_causing	0.96	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6748	6748	T	G	MI.3681	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	845	282	F	C	tTc/tGc	4.29	1	0	probably_damaging	1	neutral	0.12	neutral	2.61	deleterious	-4.04	neutral	-1.22	low_impact	1.9	0.62	neutral	0.11	damaging	4.03	23.60	deleterious	0.22	0.55	0.68	disease	0.88	disease	0.55	disease	0.76	disease	5	1	deleterious	0.06	neutral	-2	neutral	0.79	deleterious	-3.58	low_impact	-0.29	medium_impact	0.66	medium_impact	0.39	0.9	2.53	7.37	0.39	N	0.91	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6748	6748	T	C	MI.3682	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	845	282	F	S	tTc/tCc	4.29	1	0	probably_damaging	0.99	deleterious	0	neutral	2.66	neutral	-2.66	neutral	-1.44	medium_impact	2.42	0.7	neutral	0.14	damaging	3.88	23.50	deleterious	0.32	0.55	0.48	neutral	0.76	disease	0.54	disease	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-2.64	low_impact	-1.48	low_impact	1.14	medium_impact	0.57	0.9	2.53	7.37	0.39	N	0.84	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6749	6749	C	G	MI.3683	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	846	282	F	L	ttC/ttG	5.91	1	0	probably_damaging	0.96	neutral	1	neutral	2.86	neutral	-0.47	neutral	0.99	neutral_impact	-0.94	0.62	neutral	0.43	neutral	-0.26	0.82	neutral	0.27	0.55	0.17	neutral	0.35	neutral	0.25	neutral	0.45	neutral	1	0.96	neutral	0.52	deleterious	-2	neutral	0.65	deleterious	-2.06	low_impact	1.86	high_impact	-1.97	low_impact	0.75	0.9	2.53	7.37	0.47	N	0.83	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6749	6749	C	A	MI.3684	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	846	282	F	L	ttC/ttA	5.91	1	0	probably_damaging	0.96	neutral	1	neutral	2.86	neutral	-0.47	neutral	0.99	neutral_impact	-0.94	0.62	neutral	0.43	neutral	0.07	3.28	deleterious	0.27	0.55	0.17	neutral	0.35	neutral	0.25	neutral	0.45	neutral	1	0.96	neutral	0.52	deleterious	-2	neutral	0.65	deleterious	-2.06	low_impact	1.86	high_impact	-1.97	low_impact	0.75	0.9	2.53	7.37	0.49	N	0.83	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6750	6750	C	G	MI.3685	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	847	283	L	V	Cta/Gta	-4.27	0	0	probably_damaging	0.99	deleterious	0	neutral	2.66	neutral	-0.88	neutral	-1.8	high_impact	3.73	0.42	damaging	0.08	damaging	3.45	23.00	deleterious	0.43	0.55	0.28	neutral	0.74	disease	0.45	neutral	0.49	neutral	0	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-1.48	low_impact	2.35	high_impact	0.72	0.9	3.7	6.76	0.37	N	0.66	polymorphism	0.85	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6750	6750	C	A	MI.3686	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	847	283	L	M	Cta/Ata	-4.27	0	0	probably_damaging	1	deleterious	0.02	neutral	2.52	neutral	-2.82	neutral	-0.85	medium_impact	2.88	0.51	damaging	0.17	damaging	3.71	23.30	deleterious	0.27	0.55	0.52	disease	0.64	disease	0.56	disease	0.47	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.75	medium_impact	1.56	medium_impact	0.70	0.9	3.7	6.76	0.34	N	0.59	polymorphism	0.88	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6751	6751	T	C	MI.3687	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	848	283	L	P	cTa/cCa	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.67	deleterious	-4.64	high_impact	4.67	0.37	damaging	0.08	damaging	3.94	23.50	deleterious	0.17	0.55	0.94	disease	0.89	disease	0.76	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.21	high_impact	0.62	0.9	3.7	6.76	0.59	P	0.83	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6751	6751	T	A	MI.3688	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	848	283	L	Q	cTa/cAa	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-3.73	deleterious	-3.84	high_impact	4.88	0.46	damaging	0.08	damaging	4.11	23.70	deleterious	0.16	0.55	0.93	disease	0.87	disease	0.65	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.41	high_impact	0.66	0.9	3.7	6.76	0.61	P	0.82	disease_causing	0.89	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6751	6751	T	G	MI.3689	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	848	283	L	R	cTa/cGa	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.06	deleterious	-3.95	high_impact	5.22	0.45	damaging	0.07	damaging	4.20	23.90	deleterious	0.14	0.55	0.93	disease	0.95	disease	0.76	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.48	0.9	3.7	6.76	0.63	P	0.90	disease_causing	0.91	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8699	8699	T	C	MI.369	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	173	58	M	T	aTa/aCa	0.36	0.03	0	probably_damaging	0.94	neutral	0.4	neutral	4.42	neutral	0.51	deleterious	-4.26	low_impact	1.66	0.85	neutral	0.57	neutral	2.84	21.60	deleterious	0.55	0.65	NA	NA	0.62	disease	0.38	neutral	0.47	neutral	1	0.94	neutral	0.23	neutral	-2	neutral	0.75	deleterious	-1.89	low_impact	0.19	medium_impact	0.33	medium_impact	0.19	0.9	40.71	8.78	0.27	N	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6753	6753	G	T	MI.3690	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	850	284	G	W	Ggg/Tgg	-0.8	0.01	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-6.15	deleterious	-5.77	high_impact	5.25	0.42	damaging	0.02	damaging	4.43	24.20	deleterious	0.15	0.55	0.92	disease	0.93	disease	0.74	disease	0.61	disease	2	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.36	0.9	1.95	6.65	0.55	P	0.83	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6753	6753	G	C	MI.3691	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	850	284	G	R	Ggg/Cgg	-0.8	0.01	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-4.14	deleterious	-5.76	high_impact	4.7	0.44	damaging	0.02	damaging	3.94	23.50	deleterious	0.11	0.55	0.28	neutral	0.93	disease	0.79	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.64	0.9	1.95	6.65	0.53	P	0.95	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6754	6754	G	A	MI.3692	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	851	284	G	E	gGg/gAg	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-3.81	deleterious	-5.76	high_impact	5.25	0.38	damaging	0.02	damaging	4.01	23.60	deleterious	0.15	0.55	0.52	disease	0.9	disease	0.79	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.52	0.9	1.95	6.65	0.74	P	0.93	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6754	6754	G	T	MI.3693	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	851	284	G	V	gGg/gTg	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-3.38	deleterious	-6.48	high_impact	5.25	0.48	damaging	0.03	damaging	3.84	23.40	deleterious	0.14	0.55	0.61	disease	0.92	disease	0.7	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.40	0.9	1.95	6.65	0.64	P	0.93	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6754	6754	G	C	MI.3694	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	851	284	G	A	gGg/gCg	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.51	deleterious	-4.32	high_impact	4.7	0.58	damaging	0.04	damaging	3.19	22.70	deleterious	0.2	0.55	0.48	neutral	0.79	disease	0.68	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.68	0.9	1.95	6.65	0.59	P	0.64	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6756	6756	T	C	MI.3695	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	853	285	F	L	Ttt/Ctt	-20	0	0	probably_damaging	0.99	deleterious	0	neutral	2.86	neutral	-1.37	deleterious	-4.3	high_impact	3.63	0.75	neutral	0.05	damaging	4.21	23.90	deleterious	0.3	0.55	0.45	neutral	0.83	disease	0.58	disease	0.55	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	2.25	high_impact	0.76	0.9	3.7	8.17	0.27	N	0.83	polymorphism	0.81	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6756	6756	T	G	MI.3696	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	853	285	F	V	Ttt/Gtt	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.83	neutral	-1.45	deleterious	-5.02	high_impact	3.58	0.72	neutral	0.07	damaging	4.21	23.90	deleterious	0.25	0.55	0.45	neutral	0.92	disease	0.67	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.21	high_impact	0.63	0.9	3.7	8.17	0.3	N	0.84	polymorphism	0.69	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6756	6756	T	A	MI.3697	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	853	285	F	I	Ttt/Att	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.92	neutral	-1.61	deleterious	-4.3	high_impact	3.67	0.74	neutral	0.07	damaging	4.51	24.30	deleterious	0.22	0.55	0.53	disease	0.93	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.29	high_impact	0.64	0.9	3.7	8.17	0.3	N	0.88	polymorphism	0.83	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6757	6757	T	C	MI.3698	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	854	285	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-2.78	deleterious	-5.74	medium_impact	3.35	0.75	neutral	0.08	damaging	4.27	24.00	deleterious	0.24	0.55	0.58	disease	0.87	disease	0.65	disease	0.7	disease	4	1	deleterious	0	neutral	5	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	1.99	medium_impact	0.62	0.9	3.7	8.17	0.46	N	0.84	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6757	6757	T	A	MI.3699	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	854	285	F	Y	tTt/tAt	7.53	1	0	probably_damaging	0.99	deleterious	0.02	neutral	2.76	deleterious	-3.13	neutral	-2.15	high_impact	4.13	0.72	neutral	0.06	damaging	4.27	23.90	deleterious	0.29	0.55	0.51	disease	0.86	disease	0.66	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-0.75	medium_impact	2.71	high_impact	0.71	0.9	3.7	8.17	0.53	P	0.59	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8542	8542	T	A	MI.37	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	16	6	F	I	Ttc/Atc	0.13	0.97	0	probably_damaging	0.95	deleterious	0	neutral	3.93	neutral	-1.13	deleterious	-5.08	medium_impact	3.32	0.66	neutral	0.68	neutral	4.30	24.00	deleterious	0.38	0.65	0.78	disease	0.72	disease	0.8	disease	0.8	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.79	deleterious	-1.97	low_impact	-1.4	low_impact	1.75	medium_impact	0.39	0.9	39.82	8.43	0.47	N	0.95	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8700	8700	A	T	MI.370	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	174	58	M	I	atA/atT	7.53	0.97	0	probably_damaging	0.91	neutral	0.39	neutral	4.37	neutral	-0.83	neutral	-2.25	low_impact	1.34	0.81	neutral	0.56	neutral	3.24	22.80	deleterious	0.75	0.8	NA	NA	0.55	disease	0.31	neutral	0.47	neutral	1	0.91	neutral	0.24	neutral	-2	neutral	0.72	deleterious	-1.71	low_impact	0.18	medium_impact	0.05	medium_impact	0.51	0.9	40.71	8.78	0.47	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6757	6757	T	G	MI.3700	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	854	285	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	neutral	0.19	neutral	2.73	deleterious	-4.32	deleterious	-5.74	high_impact	3.63	0.74	neutral	0.06	damaging	4.15	23.80	deleterious	0.21	0.55	0.62	disease	0.88	disease	0.5	neutral	0.25	neutral	5	1	deleterious	0.1	neutral	2	deleterious	0.80	deleterious	-3.58	low_impact	-0.16	medium_impact	2.25	high_impact	0.43	0.9	3.7	8.17	0.45	N	0.91	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6758	6758	T	G	MI.3701	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	855	285	F	L	ttT/ttG	5.91	1	0	probably_damaging	0.99	deleterious	0	neutral	2.86	neutral	-1.37	deleterious	-4.3	high_impact	3.63	0.75	neutral	0.05	damaging	4.38	24.10	deleterious	0.3	0.55	0.45	neutral	0.83	disease	0.58	disease	0.55	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	2.25	high_impact	0.76	0.9	3.7	8.17	0.53	P	0.83	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6758	6758	T	A	MI.3702	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	855	285	F	L	ttT/ttA	5.91	1	0	probably_damaging	0.99	deleterious	0	neutral	2.86	neutral	-1.37	deleterious	-4.3	high_impact	3.63	0.75	neutral	0.05	damaging	4.50	24.30	deleterious	0.3	0.55	0.45	neutral	0.83	disease	0.58	disease	0.55	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	2.25	high_impact	0.76	0.9	3.7	8.17	0.54	P	0.83	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6759	6759	A	G	MI.3703	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	856	286	I	V	Atc/Gtc	-2.65	0	0	possibly_damaging	0.84	neutral	0.36	neutral	2.93	neutral	-0.55	neutral	-0.11	neutral_impact	0.44	0.71	neutral	0.3	neutral	1.36	12.56	neutral	0.6	0.65	0.19	neutral	0.12	neutral	0.38	neutral	0.27	neutral	5	0.85	neutral	0.26	neutral	-3	neutral	0.50	deleterious	-1.43	low_impact	0.05	medium_impact	-0.69	medium_impact	0.70	0.9	3.31	6.76	0.39	N	0.23	disease_causing	0.96	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6759	6759	A	C	MI.3704	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	856	286	I	L	Atc/Ctc	-2.65	0	0	probably_damaging	0.94	neutral	0.05	neutral	3.02	neutral	0.11	neutral	-0.99	low_impact	1.51	0.62	neutral	0.2	damaging	2.58	19.96	deleterious	0.35	0.55	0.17	neutral	0.55	disease	0.37	neutral	0.23	neutral	5	0.99	deleterious	0.06	neutral	-2	neutral	0.55	deleterious	-1.88	low_impact	-0.52	medium_impact	0.3	medium_impact	0.78	0.9	3.31	6.76	0.39	N	0.61	disease_causing	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6759	6759	A	T	MI.3705	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	856	286	I	F	Atc/Ttc	-2.65	0	0	probably_damaging	0.99	deleterious	0	neutral	2.85	neutral	-1.64	deleterious	-2.6	medium_impact	2.75	0.61	neutral	0.1	damaging	3.77	23.40	deleterious	0.29	0.55	0.38	neutral	0.79	disease	0.43	neutral	0.46	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	1.44	medium_impact	0.80	0.9	3.31	6.76	0.28	N	0.85	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6760	6760	T	G	MI.3706	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	857	286	I	S	aTc/aGc	5.68	1	0	probably_damaging	1	neutral	0.05	neutral	2.83	neutral	-2.17	deleterious	-3.73	medium_impact	3.4	0.65	neutral	0.17	damaging	4.27	24.00	deleterious	0.28	0.55	0.45	neutral	0.81	disease	0.61	disease	0.67	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.58	low_impact	-0.52	medium_impact	2.04	high_impact	0.56	0.9	3.31	6.76	0.49	P	0.62	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6760	6760	T	C	MI.3707	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	857	286	I	T	aTc/aCc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-1.95	deleterious	-2.73	medium_impact	3.1	0.63	neutral	0.16	damaging	3.45	23.00	deleterious	0.44	0.55	0.18	neutral	0.69	disease	0.59	disease	0.65	disease	3	1	deleterious	0	neutral	5	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	1.76	medium_impact	0.68	0.9	3.31	6.76	0.43	N	0.76	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6760	6760	T	A	MI.3708	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	857	286	I	N	aTc/aAc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.81	neutral	-2.57	deleterious	-4.45	high_impact	4.59	0.59	damaging	0.12	damaging	4.38	24.10	deleterious	0.25	0.55	0.5	disease	0.81	disease	0.61	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.14	high_impact	0.64	0.9	3.31	6.76	0.5	P	0.94	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6761	6761	C	A	MI.3709	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	858	286	I	M	atC/atA	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-2.39	neutral	-1.45	medium_impact	3.15	0.65	neutral	0.17	damaging	3.89	23.50	deleterious	0.39	0.55	0.33	neutral	0.56	disease	0.4	neutral	0.38	neutral	2	1	deleterious	0	neutral	5	deleterious	0.70	deleterious	-3.58	low_impact	-1.48	low_impact	1.81	medium_impact	0.84	0.9	3.31	6.76	0.47	N	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8700	8700	A	C	MI.371	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	174	58	M	I	atA/atC	7.53	0.97	0	probably_damaging	0.91	neutral	0.39	neutral	4.37	neutral	-0.83	neutral	-2.25	low_impact	1.34	0.81	neutral	0.56	neutral	3.19	22.70	deleterious	0.75	0.8	NA	NA	0.55	disease	0.31	neutral	0.47	neutral	1	0.91	neutral	0.24	neutral	-2	neutral	0.72	deleterious	-1.71	low_impact	0.18	medium_impact	0.05	medium_impact	0.51	0.9	40.71	8.78	0.46	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6761	6761	C	G	MI.3710	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	858	286	I	M	atC/atG	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-2.39	neutral	-1.45	medium_impact	3.15	0.65	neutral	0.17	damaging	3.38	22.90	deleterious	0.39	0.55	0.33	neutral	0.56	disease	0.4	neutral	0.38	neutral	2	1	deleterious	0	neutral	5	deleterious	0.70	deleterious	-3.58	low_impact	-1.48	low_impact	1.81	medium_impact	0.84	0.9	3.31	6.76	0.47	N	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6762	6762	G	C	MI.3711	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	859	287	V	L	Gtg/Ctg	-4.04	0	0	probably_damaging	0.97	deleterious	0	neutral	2.3	deleterious	-3.42	neutral	-2.14	high_impact	4.5	0.67	neutral	0.06	damaging	3.56	23.10	deleterious	0.31	0.55	0.5	disease	0.79	disease	0.63	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-2.18	low_impact	-1.48	low_impact	3.06	high_impact	0.59	0.9	2.53	6.69	0.38	N	0.55	polymorphism	0.94	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6762	6762	G	T	MI.3712	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	859	287	V	L	Gtg/Ttg	-4.04	0	0	probably_damaging	0.97	deleterious	0	neutral	2.3	deleterious	-3.42	neutral	-2.14	high_impact	4.5	0.67	neutral	0.06	damaging	3.71	23.30	deleterious	0.31	0.55	0.5	disease	0.79	disease	0.63	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-2.18	low_impact	-1.48	low_impact	3.06	high_impact	0.59	0.9	2.53	6.69	0.38	N	0.55	polymorphism	0.94	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6762	6762	G	A	MI.3713	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	859	287	V	M	Gtg/Atg	-4.04	0	0	probably_damaging	1	deleterious	0	neutral	2.21	deleterious	-5.39	neutral	-2.14	high_impact	5.3	0.67	neutral	0.08	damaging	3.70	23.30	deleterious	0.25	0.55	0.84	disease	0.79	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.73	0.9	2.53	6.69	0.65	P	0.82	polymorphism	0.94	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6763	6763	T	A	MI.3714	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	860	287	V	E	gTg/gAg	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.21	deleterious	-6.43	deleterious	-4.28	high_impact	5.3	0.64	neutral	0.09	damaging	4.82	24.80	deleterious	0.1	0.55	0.91	disease	0.89	disease	0.78	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.8	high_impact	0.47	0.9	2.53	6.69	0.72	P	0.84	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6763	6763	T	C	MI.3715	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	860	287	V	A	gTg/gCg	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.37	deleterious	-4.21	deleterious	-2.85	high_impact	4.95	0.66	neutral	0.13	damaging	3.60	23.20	deleterious	0.23	0.55	0.76	disease	0.72	disease	0.61	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.42	0.9	2.53	6.69	0.73	P	0.47	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6763	6763	T	G	MI.3716	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	860	287	V	G	gTg/gGg	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.35	deleterious	-5.89	deleterious	-4.99	high_impact	4.95	0.64	neutral	0.12	damaging	3.89	23.50	deleterious	0.13	0.55	0.9	disease	0.83	disease	0.67	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.51	0.9	2.53	6.69	0.68	P	0.71	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6765	6765	T	C	MI.3717	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	862	288	W	R	Tga/Cga	-4.27	0	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-4.38	deleterious	-9.77	high_impact	4.59	0.62	neutral	0.23	damaging	3.61	23.20	deleterious	0.2	0.55	0.78	disease	0.95	disease	0.85	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.14	high_impact	0.19	0.9	4.48	6.79	0.52	N	0.98	disease_causing	0.92	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6765	6765	T	G	MI.3718	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	862	288	W	G	Tga/Gga	-4.27	0	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-2.18	deleterious	-9.07	high_impact	4.74	0.62	neutral	0.42	neutral	3.93	23.50	deleterious	0.17	0.55	0.52	disease	0.89	disease	0.8	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.28	high_impact	0.17	0.9	4.48	6.79	0.63	P	0.89	disease_causing	0.97	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6766	6766	G	T	MI.3719	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	863	288	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.29	deleterious	-9.07	high_impact	4.25	0.63	neutral	0.37	neutral	4.37	24.10	deleterious	0.16	0.55	0.77	disease	0.89	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.16	0.9	4.48	6.79	0.58	P	0.95	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8701	8701	A	T	MI.372	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	175	59	T	S	Acc/Tcc	-1.72	0	0.71	benign	0.14	neutral	0.51	neutral	4.44	neutral	0.53	neutral	-0.64	neutral_impact	-0.26	0.9	neutral	0.98	neutral	-1.23	0.01	neutral	0.81	0.85	NA	NA	0.14	neutral	0.28	neutral	0.21	neutral	6	0.4	neutral	0.69	deleterious	-6	neutral	0.19	neutral	-0.01	medium_impact	0.3	medium_impact	-1.32	low_impact	0.83	0.9	24.34	15.68	0.42	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6766	6766	G	C	MI.3720	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	863	288	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-4.14	deleterious	-9.76	high_impact	5.29	0.7	neutral	0.41	neutral	4.09	23.70	deleterious	0.17	0.55	0.75	disease	0.92	disease	0.8	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.14	0.9	4.48	6.79	0.63	P	0.89	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6767	6767	A	C	MI.3721	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	864	288	W	C	tgA/tgC	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-6.01	deleterious	-9.07	high_impact	5.29	0.6	neutral	0.24	damaging	4.07	23.70	deleterious	0.2	0.55	0.93	disease	0.93	disease	0.83	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.22	0.9	4.48	6.79	0.62	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6767	6767	A	T	MI.3722	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	864	288	W	C	tgA/tgT	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-6.01	deleterious	-9.07	high_impact	5.29	0.6	neutral	0.24	damaging	4.19	23.80	deleterious	0.2	0.55	0.93	disease	0.93	disease	0.83	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.22	0.9	4.48	6.79	0.62	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6768	6768	G	T	MI.3723	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	865	289	A	S	Gca/Tca	0.82	0.99	0	probably_damaging	1	deleterious	0	neutral	2.55	neutral	-2.54	neutral	-2.08	high_impact	3.71	0.65	neutral	0.07	damaging	3.79	23.40	deleterious	0.3	0.55	0.33	neutral	0.76	disease	0.4	neutral	0.21	neutral	6	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.33	high_impact	0.88	0.9	2.53	6.62	0.39	N	0.64	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6768	6768	G	C	MI.3724	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	865	289	A	P	Gca/Cca	0.82	0.99	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.51	deleterious	-3.49	high_impact	4.81	0.55	damaging	0.06	damaging	3.89	23.50	deleterious	0.13	0.55	0.66	disease	0.89	disease	0.74	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.34	high_impact	0.84	0.9	2.53	6.62	0.68	P	0.85	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6768	6768	G	A	MI.3725	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	865	289	A	T	Gca/Aca	0.82	0.99	0	probably_damaging	1	deleterious	0	neutral	2.57	neutral	-2.24	deleterious	-2.78	high_impact	5.16	0.62	neutral	0.07	damaging	4.24	23.90	deleterious	0.28	0.55	0.36	neutral	0.86	disease	0.63	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.77	0.9	2.53	6.62	0.66	P	0.20	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6769	6769	C	T	MI.3726	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	866	289	A	V	gCa/gTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-0.79	deleterious	-2.79	high_impact	3.96	0.61	neutral	0.06	damaging	4.44	24.20	deleterious	0.27	0.55	0.24	neutral	0.9	disease	0.63	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.75	0.9	2.53	6.62	0.51	P	0.75	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6769	6769	C	G	MI.3727	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	866	289	A	G	gCa/gGa	7.53	1	0	probably_damaging	0.99	neutral	0.17	neutral	2.73	neutral	-0.42	deleterious	-2.77	medium_impact	2.14	0.64	neutral	0.07	damaging	3.93	23.50	deleterious	0.24	0.55	0.31	neutral	0.71	disease	0.37	neutral	0.21	neutral	6	1	deleterious	0.09	neutral	1	deleterious	0.77	deleterious	-2.64	low_impact	-0.19	medium_impact	0.88	medium_impact	0.86	0.9	2.53	6.62	0.47	N	0.56	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6769	6769	C	A	MI.3728	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	866	289	A	E	gCa/gAa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-3.83	deleterious	-3.48	high_impact	5.16	0.6	neutral	0.07	damaging	4.53	24.30	deleterious	0.12	0.55	0.48	neutral	0.92	disease	0.72	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.76	0.9	2.53	6.62	0.72	P	0.76	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6771	6771	C	G	MI.3729	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	868	290	H	D	Cac/Gac	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	1.09	deleterious	-7.42	deleterious	-6.26	high_impact	5.29	0.52	damaging	0.04	damaging	3.92	23.50	deleterious	0.21	0.55	0.62	disease	0.88	disease	0.83	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.57	0.9	2.14	7.15	0.53	P	0.97	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8701	8701	A	C	MI.373	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	175	59	T	P	Acc/Ccc	-1.72	0	0.71	possibly_damaging	0.48	neutral	0.24	neutral	4.3	neutral	-2.24	neutral	-2.35	low_impact	1.54	0.85	neutral	0.52	neutral	0.45	7.08	deleterious	0.4	0.65	NA	NA	0.63	disease	0.57	disease	0.67	disease	3	0.73	neutral	0.38	neutral	-3	neutral	0.58	deleterious	-0.72	medium_impact	0.01	medium_impact	0.22	medium_impact	0.72	0.9	24.34	15.68	0.3	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6771	6771	C	A	MI.3730	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	868	290	H	N	Cac/Aac	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	1.09	deleterious	-7.46	deleterious	-4.87	high_impact	5.29	0.57	damaging	0.04	damaging	3.98	23.60	deleterious	0.35	0.55	0.81	disease	0.87	disease	0.81	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.61	0.9	2.14	7.15	0.62	P	0.86	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6771	6771	C	T	MI.3731	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	868	290	H	Y	Cac/Tac	-2.42	0	0	probably_damaging	1	deleterious	0	neutral	1.08	deleterious	-7.68	deleterious	-4.17	high_impact	4.95	0.6	damaging	0.04	damaging	3.80	23.40	deleterious	0.33	0.55	0.89	disease	0.92	disease	0.81	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.47	high_impact	0.52	0.9	2.14	7.15	0.64	P	0.72	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6772	6772	A	G	MI.3732	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	869	290	H	R	cAc/cGc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	1.09	deleterious	-7.14	deleterious	-5.57	high_impact	4.74	0.61	neutral	0.04	damaging	2.92	21.90	deleterious	0.35	0.55	0.86	disease	0.93	disease	0.8	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.28	high_impact	0.44	0.9	2.14	7.15	0.65	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6772	6772	A	C	MI.3733	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	869	290	H	P	cAc/cCc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	1.08	deleterious	-8.22	deleterious	-6.95	high_impact	4.59	0.51	damaging	0.05	damaging	3.17	22.70	deleterious	0.2	0.55	0.91	disease	0.9	disease	0.87	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.14	high_impact	0.50	0.9	2.14	7.15	0.52	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6772	6772	A	T	MI.3734	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	869	290	H	L	cAc/cTc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	1.09	deleterious	-7.22	deleterious	-7.64	high_impact	5.29	0.66	neutral	0.03	damaging	3.74	23.30	deleterious	0.19	0.55	0.9	disease	0.92	disease	0.8	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.40	0.9	2.14	7.15	0.65	P	0.92	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6773	6773	C	A	MI.3735	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	870	290	H	Q	caC/caA	7.07	1	0	probably_damaging	1	deleterious	0	neutral	1.08	deleterious	-7.61	deleterious	-5.56	high_impact	5.29	0.63	neutral	0.04	damaging	3.95	23.60	deleterious	0.36	0.55	0.84	disease	0.85	disease	0.81	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.56	0.9	2.14	7.15	0.66	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6773	6773	C	G	MI.3736	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	870	290	H	Q	caC/caG	7.07	1	0	probably_damaging	1	deleterious	0	neutral	1.08	deleterious	-7.61	deleterious	-5.56	high_impact	5.29	0.63	neutral	0.04	damaging	3.61	23.20	deleterious	0.36	0.55	0.84	disease	0.85	disease	0.81	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.56	0.9	2.14	7.15	0.66	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6774	6774	C	A	MI.3737	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	871	291	H	N	Cat/Aat	-4.5	0	0	probably_damaging	0.98	deleterious	0	neutral	0.57	deleterious	-9.08	deleterious	-4.78	high_impact	5.28	0.55	damaging	0.04	damaging	4.12	23.80	deleterious	0.25	0.55	0.82	disease	0.87	disease	0.81	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.35	low_impact	-1.48	low_impact	3.78	high_impact	0.59	0.9	2.73	6.78	0.57	P	0.86	disease_causing	0.94	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6774	6774	C	T	MI.3738	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	871	291	H	Y	Cat/Tat	-4.5	0	0	probably_damaging	0.98	deleterious	0	neutral	0.65	deleterious	-5.86	deleterious	-4.09	high_impact	4.73	0.56	damaging	0.03	damaging	3.72	23.30	deleterious	0.26	0.55	0.87	disease	0.91	disease	0.82	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.35	low_impact	-1.48	low_impact	3.27	high_impact	0.58	0.9	2.73	6.78	0.62	P	0.72	disease_causing	0.95	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6774	6774	C	G	MI.3739	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	871	291	H	D	Cat/Gat	-4.5	0	0	probably_damaging	0.99	deleterious	0	neutral	0.57	deleterious	-9.16	deleterious	-6.14	high_impact	4.59	0.49	damaging	0.04	damaging	3.88	23.50	deleterious	0.18	0.55	0.78	disease	0.88	disease	0.86	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.64	low_impact	-1.48	low_impact	3.14	high_impact	0.53	0.9	2.73	6.78	0.42	N	0.97	disease_causing	0.98	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8701	8701	A	G	MI.374	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	175	59	T	A	Acc/Gcc	-1.72	0	0.71	benign	0.01	neutral	0.6	neutral	4.37	neutral	-0.27	neutral	-0.94	neutral_impact	0.36	0.98	neutral	0.98	neutral	-0.66	0.09	neutral	0.73	0.75	NA	NA	0.18	neutral	0.38	neutral	0.22	neutral	6	0.39	neutral	0.8	deleterious	-6	neutral	0.07	neutral	1.14	medium_impact	0.39	medium_impact	-0.79	medium_impact	0.36	0.9	24.34	15.68	0.29	N	0.03	polymorphism	1	0.02	rs2000975	.	.	.	.	thyroid tumors	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6775	6775	A	C	MI.3740	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	872	291	H	P	cAt/cCt	7.3	1	0	probably_damaging	0.99	deleterious	0	neutral	0.57	deleterious	-10.12	deleterious	-6.82	high_impact	4.59	0.49	damaging	0.04	damaging	3.31	22.90	deleterious	0.18	0.55	0.9	disease	0.9	disease	0.86	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.92	deleterious	-2.64	low_impact	-1.48	low_impact	3.14	high_impact	0.55	0.9	2.73	6.78	0.5	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6775	6775	A	T	MI.3741	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	872	291	H	L	cAt/cTt	7.3	1	0	probably_damaging	0.98	deleterious	0	neutral	0.58	deleterious	-8.16	deleterious	-7.5	high_impact	5.28	0.68	neutral	0.03	damaging	3.96	23.60	deleterious	0.14	0.55	0.86	disease	0.92	disease	0.79	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.35	low_impact	-1.48	low_impact	3.78	high_impact	0.51	0.9	2.73	6.78	0.62	P	0.92	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6775	6775	A	G	MI.3742	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	872	291	H	R	cAt/cGt	7.3	1	0	probably_damaging	0.98	deleterious	0	neutral	0.58	deleterious	-8.74	deleterious	-5.46	high_impact	5.28	0.57	damaging	0.04	damaging	3.08	22.50	deleterious	0.28	0.55	0.7	disease	0.93	disease	0.83	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.35	low_impact	-1.48	low_impact	3.78	high_impact	0.55	0.9	2.73	6.78	0.59	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6776	6776	T	A	MI.3743	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	873	291	H	Q	caT/caA	8.69	1	0.1	probably_damaging	0.99	deleterious	0	neutral	0.57	deleterious	-9.16	deleterious	-5.46	high_impact	5.28	0.62	neutral	0.04	damaging	3.71	23.30	deleterious	0.25	0.55	0.8	disease	0.85	disease	0.8	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.64	low_impact	-1.48	low_impact	3.78	high_impact	0.61	0.9	2.73	6.78	0.65	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6776	6776	T	G	MI.3744	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	873	291	H	Q	caT/caG	8.69	1	0.1	probably_damaging	0.99	deleterious	0	neutral	0.57	deleterious	-9.16	deleterious	-5.46	high_impact	5.28	0.62	neutral	0.04	damaging	3.62	23.20	deleterious	0.25	0.55	0.8	disease	0.85	disease	0.8	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.64	low_impact	-1.48	low_impact	3.78	high_impact	0.61	0.9	2.73	6.78	0.65	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6777	6777	A	G	MI.3745	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	874	292	M	V	Ata/Gta	-4.5	0	0	probably_damaging	0.97	deleterious	0	neutral	2.61	neutral	-2.14	deleterious	-2.73	high_impact	5.28	0.61	neutral	0.05	damaging	2.65	20.50	deleterious	0.4	0.55	0.54	disease	0.91	disease	0.75	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-2.18	low_impact	-1.48	low_impact	3.78	high_impact	0.55	0.9	2.73	6.76	0.59	P	0.88	polymorphism	0.74	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6777	6777	A	T	MI.3746	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	874	292	M	L	Ata/Tta	-4.5	0	0	probably_damaging	0.95	deleterious	0	neutral	2.79	neutral	-0.87	neutral	-2.05	high_impact	4.38	0.66	neutral	0.04	damaging	3.29	22.80	deleterious	0.39	0.55	0.33	neutral	0.86	disease	0.67	disease	0.58	disease	2	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-1.96	low_impact	-1.48	low_impact	2.95	high_impact	0.49	0.9	2.73	6.76	0.39	N	0.61	polymorphism	0.78	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6777	6777	A	C	MI.3747	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	874	292	M	L	Ata/Cta	-4.5	0	0	probably_damaging	0.95	deleterious	0	neutral	2.79	neutral	-0.87	neutral	-2.05	high_impact	4.38	0.66	neutral	0.04	damaging	3.19	22.70	deleterious	0.39	0.55	0.33	neutral	0.86	disease	0.67	disease	0.58	disease	2	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-1.96	low_impact	-1.48	low_impact	2.95	high_impact	0.49	0.9	2.73	6.76	0.39	N	0.61	polymorphism	0.78	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6778	6778	T	C	MI.3748	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	875	292	M	T	aTa/aCa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-3.14	deleterious	-4.09	high_impact	4.93	0.66	neutral	0.06	damaging	3.01	22.30	deleterious	0.37	0.55	0.7	disease	0.91	disease	0.74	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.41	0.9	2.73	6.76	0.73	P	0.79	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6778	6778	T	A	MI.3749	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	875	292	M	K	aTa/aAa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.31	deleterious	-4.09	high_impact	5.28	0.61	neutral	0.03	damaging	4.01	23.60	deleterious	0.17	0.55	0.77	disease	0.94	disease	0.82	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.37	0.9	2.73	6.76	0.75	P	0.93	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8702	8702	C	G	MI.375	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	176	59	T	S	aCc/aGc	-7.51	0	0.01	benign	0.14	neutral	0.51	neutral	4.44	neutral	0.53	neutral	-0.64	neutral_impact	-0.26	0.9	neutral	0.98	neutral	-1.05	0.01	neutral	0.81	0.85	NA	NA	0.14	neutral	0.28	neutral	0.21	neutral	6	0.4	neutral	0.69	deleterious	-6	neutral	0.19	neutral	-0.01	medium_impact	0.3	medium_impact	-1.32	low_impact	0.83	0.9	24.34	15.68	0.37	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6779	6779	A	C	MI.3750	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	876	292	M	I	atA/atC	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.6	neutral	-2.3	deleterious	-2.73	high_impact	4.58	0.55	damaging	0.06	damaging	3.44	23.00	deleterious	0.38	0.55	0.52	disease	0.92	disease	0.7	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.35	low_impact	-1.48	low_impact	3.13	high_impact	0.63	0.9	2.73	6.76	0.53	P	0.87	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6779	6779	A	T	MI.3751	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	876	292	M	I	atA/atT	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.6	neutral	-2.3	deleterious	-2.73	high_impact	4.58	0.55	damaging	0.06	damaging	3.46	23.00	deleterious	0.38	0.55	0.52	disease	0.92	disease	0.7	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.35	low_impact	-1.48	low_impact	3.13	high_impact	0.63	0.9	2.73	6.76	0.55	P	0.87	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6780	6780	T	C	MI.3752	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	877	293	F	L	Ttt/Ctt	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-2.49	deleterious	-4.07	high_impact	4.63	0.52	damaging	0.14	damaging	4.08	23.70	deleterious	0.38	0.55	0.77	disease	0.85	disease	0.62	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.18	high_impact	0.87	0.9	2.73	6.71	0.46	N	0.83	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6780	6780	T	G	MI.3753	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	877	293	F	V	Ttt/Gtt	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-3.43	deleterious	-4.74	high_impact	4.84	0.52	damaging	0.11	damaging	4.03	23.70	deleterious	0.28	0.55	0.88	disease	0.94	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.67	0.9	2.73	6.71	0.62	P	0.84	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6780	6780	T	A	MI.3754	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	877	293	F	I	Ttt/Att	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-3.89	deleterious	-4.07	high_impact	4.03	0.59	damaging	0.14	damaging	4.42	24.20	deleterious	0.22	0.55	0.88	disease	0.92	disease	0.64	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.62	high_impact	0.72	0.9	2.73	6.71	0.32	N	0.88	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6781	6781	T	A	MI.3755	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	878	293	F	Y	tTt/tAt	4.76	1	0	probably_damaging	1	neutral	0.17	neutral	2.62	neutral	-1.68	neutral	-1.99	medium_impact	2.47	0.57	damaging	0.12	damaging	4.36	24.10	deleterious	0.29	0.55	0.36	neutral	0.74	disease	0.45	neutral	0.36	neutral	3	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.58	low_impact	-0.19	medium_impact	1.18	medium_impact	0.80	0.9	2.73	6.71	0.5	P	0.59	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6781	6781	T	G	MI.3756	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	878	293	F	C	tTt/tGt	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-6.31	deleterious	-5.43	high_impact	5.18	0.54	damaging	0.12	damaging	4.15	23.80	deleterious	0.23	0.55	0.97	disease	0.93	disease	0.72	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.43	0.9	2.73	6.71	0.62	P	0.91	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6781	6781	T	C	MI.3757	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	878	293	F	S	tTt/tCt	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.91	deleterious	-5.42	high_impact	4.49	0.64	neutral	0.15	damaging	4.36	24.10	deleterious	0.24	0.55	0.92	disease	0.91	disease	0.7	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.05	high_impact	0.60	0.9	2.73	6.71	0.52	P	0.84	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6782	6782	T	A	MI.3758	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	879	293	F	L	ttT/ttA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-2.49	deleterious	-4.07	high_impact	4.63	0.52	damaging	0.14	damaging	4.50	24.30	deleterious	0.38	0.55	0.77	disease	0.85	disease	0.62	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.18	high_impact	0.87	0.9	2.73	6.71	0.62	P	0.83	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6782	6782	T	G	MI.3759	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	879	293	F	L	ttT/ttG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-2.49	deleterious	-4.07	high_impact	4.63	0.52	damaging	0.14	damaging	4.38	24.10	deleterious	0.38	0.55	0.77	disease	0.85	disease	0.62	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.18	high_impact	0.87	0.9	2.73	6.71	0.61	P	0.83	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8702	8702	C	A	MI.376	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	176	59	T	N	aCc/aAc	-7.51	0	0.01	possibly_damaging	0.56	neutral	0.39	neutral	4.37	neutral	-0.36	neutral	-1.92	low_impact	0.9	0.89	neutral	0.83	neutral	1.67	14.21	neutral	0.78	0.8	NA	NA	0.31	neutral	0.29	neutral	0.15	neutral	7	0.62	neutral	0.42	neutral	-3	neutral	0.54	deleterious	-0.86	medium_impact	0.18	medium_impact	-0.33	medium_impact	0.77	0.9	24.34	15.68	0.42	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6783	6783	A	C	MI.3760	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	880	294	T	P	Aca/Cca	-2.19	0	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.49	deleterious	-3.65	high_impact	5.16	0.63	neutral	0.14	damaging	3.58	23.20	deleterious	0.14	0.55	0.82	disease	0.86	disease	0.61	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.68	0.9	1.95	6.72	0.68	P	0.92	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6783	6783	A	T	MI.3761	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	880	294	T	S	Aca/Tca	-2.19	0	0	probably_damaging	0.98	deleterious	0.04	neutral	2.55	neutral	-2.52	neutral	-2	medium_impact	3.04	0.77	neutral	0.16	damaging	3.35	22.90	deleterious	0.47	0.55	0.63	disease	0.73	disease	0.48	neutral	0.48	neutral	0	1	deleterious	0.03	neutral	5	deleterious	0.79	deleterious	-2.35	low_impact	-0.58	medium_impact	1.71	medium_impact	0.72	0.9	1.95	6.72	0.28	N	0.79	disease_causing	0.9	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6783	6783	A	G	MI.3762	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	880	294	T	A	Aca/Gca	-2.19	0	0	probably_damaging	0.98	deleterious	0	neutral	2.59	neutral	-1.75	deleterious	-2.87	medium_impact	3.24	0.64	neutral	0.16	damaging	3.54	23.10	deleterious	0.58	0.65	0.46	neutral	0.76	disease	0.52	disease	0.55	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-2.35	low_impact	-1.48	low_impact	1.89	medium_impact	0.69	0.9	1.95	6.72	0.33	N	0.69	disease_causing	0.96	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6784	6784	C	A	MI.3763	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	881	294	T	K	aCa/aAa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-3.61	deleterious	-3.56	high_impact	5.16	0.67	neutral	0.1	damaging	4.46	24.20	deleterious	0.2	0.55	0.7	disease	0.91	disease	0.74	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.73	0.9	1.95	6.72	0.75	P	0.88	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6784	6784	C	T	MI.3764	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	881	294	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.55	neutral	-2.73	deleterious	-3.66	high_impact	3.91	0.77	neutral	0.12	damaging	4.07	23.70	deleterious	0.39	0.55	0.72	disease	0.84	disease	0.52	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.51	high_impact	0.76	0.9	1.95	6.72	0.44	N	0.96	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6786	6786	G	C	MI.3765	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	883	295	V	L	Gta/Cta	-7.97	0	0	probably_damaging	0.99	deleterious	0	neutral	2.73	neutral	-0.8	neutral	-1.86	high_impact	5.07	0.63	neutral	0.12	damaging	3.67	23.30	deleterious	0.4	0.55	0.41	neutral	0.82	disease	0.64	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.58	high_impact	0.77	0.9	2.92	7.3	0.67	P	0.55	polymorphism	0.94	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6786	6786	G	A	MI.3766	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	883	295	V	M	Gta/Ata	-7.97	0	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-1.06	neutral	-1.94	high_impact	3.92	0.66	neutral	0.15	damaging	3.80	23.40	deleterious	0.34	0.55	0.41	neutral	0.82	disease	0.52	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.52	high_impact	0.77	0.9	2.92	7.3	0.35	N	0.82	polymorphism	0.94	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6786	6786	G	T	MI.3767	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	883	295	V	L	Gta/Tta	-7.97	0	0	probably_damaging	0.99	deleterious	0	neutral	2.73	neutral	-0.8	neutral	-1.86	high_impact	5.07	0.63	neutral	0.12	damaging	3.78	23.40	deleterious	0.4	0.55	0.41	neutral	0.82	disease	0.64	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.58	high_impact	0.77	0.9	2.92	7.3	0.67	P	0.55	polymorphism	0.94	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6787	6787	T	G	MI.3768	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	884	295	V	G	gTa/gGa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-1.09	deleterious	-4.73	high_impact	4.72	0.52	damaging	0.17	damaging	3.94	23.50	deleterious	0.15	0.55	0.61	disease	0.89	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.53	0.9	2.92	7.3	0.7	P	0.71	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6787	6787	T	C	MI.3769	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	884	295	V	A	gTa/gCa	9.15	1	0	probably_damaging	1	deleterious	0.04	neutral	2.76	neutral	-0.45	deleterious	-2.69	high_impact	3.75	0.53	damaging	0.18	damaging	3.69	23.30	deleterious	0.37	0.55	0.36	neutral	0.76	disease	0.57	disease	0.55	disease	1	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-0.58	medium_impact	2.36	high_impact	0.56	0.9	2.92	7.3	0.52	P	0.47	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8702	8702	C	T	MI.377	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	176	59	T	I	aCc/aTc	-7.51	0	0.01	benign	0.01	neutral	0.42	neutral	4.3	neutral	-2.41	neutral	-1.02	neutral_impact	0.79	0.93	neutral	0.96	neutral	0.29	5.56	deleterious	0.58	0.7	NA	NA	0.3	neutral	0.33	neutral	0.14	neutral	7	0.57	neutral	0.71	deleterious	-6	neutral	0.11	neutral	1.14	medium_impact	0.21	medium_impact	-0.42	medium_impact	0.46	0.9	24.34	15.68	0.35	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6787	6787	T	A	MI.3770	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	884	295	V	E	gTa/gAa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-2.72	deleterious	-4.05	high_impact	5.07	0.63	neutral	0.15	damaging	5.02	25.20	deleterious	0.09	0.55	0.45	neutral	0.92	disease	0.77	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.58	high_impact	0.42	0.9	2.92	7.3	0.75	P	0.84	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6789	6789	G	C	MI.3771	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	886	296	G	R	Gga/Cga	-3.8	0	0	probably_damaging	1	deleterious	0	neutral	2.02	deleterious	-5.11	deleterious	-5.39	high_impact	4.93	0.68	neutral	0.08	damaging	4.02	23.60	deleterious	0.14	0.55	0.74	disease	0.91	disease	0.82	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.76	0.9	2.92	6.67	0.66	P	0.95	disease_causing	0.83	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6789	6789	G	T	MI.3772	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	886	296	G	W	Gga/Tga	-3.8	0	0	probably_damaging	1	deleterious	0	neutral	1.99	deleterious	-8.55	deleterious	-5.41	high_impact	5.28	0.68	neutral	0.09	damaging	4.47	24.20	deleterious	0.14	0.55	0.94	disease	0.91	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.33	0.9	2.92	6.67	0.6	P	0.83	disease_causing	0.89	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6790	6790	G	A	MI.3773	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	887	296	G	E	gGa/gAa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.05	deleterious	-4.06	deleterious	-5.36	high_impact	5.28	0.58	damaging	0.13	damaging	4.00	23.60	deleterious	0.16	0.55	0.7	disease	0.89	disease	0.82	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.69	0.9	2.92	6.67	0.75	P	0.93	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6790	6790	G	T	MI.3774	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	887	296	G	V	gGa/gTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.03	deleterious	-4.82	deleterious	-6.07	high_impact	4.59	0.64	neutral	0.09	damaging	3.85	23.40	deleterious	0.13	0.55	0.65	disease	0.91	disease	0.72	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.14	high_impact	0.50	0.9	2.92	6.67	0.5	N	0.93	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6790	6790	G	C	MI.3775	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	887	296	G	A	gGa/gCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.05	deleterious	-4.09	deleterious	-4.04	high_impact	4.93	0.74	neutral	0.14	damaging	3.22	22.70	deleterious	0.22	0.55	0.57	disease	0.78	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.68	0.9	2.92	6.67	0.71	P	0.64	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6792	6792	A	G	MI.3776	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	889	297	M	V	Ata/Gta	-7.74	0	0	possibly_damaging	0.89	deleterious	0	neutral	2.98	neutral	-0.72	neutral	-2.41	high_impact	4.39	0.62	neutral	0.12	damaging	2.85	21.60	deleterious	0.45	0.55	0.22	neutral	0.88	disease	0.58	disease	0.69	disease	4	1	deleterious	0.06	neutral	5	deleterious	0.70	deleterious	-1.61	low_impact	-1.48	low_impact	2.95	high_impact	0.43	0.9	8.38	36.17	0.34	N	0.46	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6792	6792	A	C	MI.3777	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	889	297	M	L	Ata/Cta	-7.74	0	0	possibly_damaging	0.84	neutral	0.36	neutral	3.14	neutral	0.29	neutral	-1.6	low_impact	1.32	0.64	neutral	0.89	neutral	2.14	17.14	deleterious	0.48	0.55	0.22	neutral	0.59	disease	0.28	neutral	0.41	neutral	2	0.85	neutral	0.26	neutral	-3	neutral	0.57	deleterious	-1.43	low_impact	0.05	medium_impact	0.12	medium_impact	0.48	0.9	8.38	36.17	0.43	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6792	6792	A	T	MI.3778	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	889	297	M	L	Ata/Tta	-7.74	0	0	possibly_damaging	0.84	neutral	0.36	neutral	3.14	neutral	0.29	neutral	-1.6	low_impact	1.32	0.64	neutral	0.89	neutral	2.25	17.83	deleterious	0.48	0.55	0.22	neutral	0.59	disease	0.28	neutral	0.41	neutral	2	0.85	neutral	0.26	neutral	-3	neutral	0.57	deleterious	-1.43	low_impact	0.05	medium_impact	0.12	medium_impact	0.48	0.9	8.38	36.17	0.43	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6793	6793	T	C	MI.3779	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	890	297	M	T	aTa/aCa	1.98	0.87	0	probably_damaging	0.98	deleterious	0	neutral	2.93	neutral	-1.55	deleterious	-3.72	high_impact	3.9	0.67	neutral	0.17	damaging	3.11	22.50	deleterious	0.44	0.55	0.27	neutral	0.9	disease	0.69	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.35	low_impact	-1.48	low_impact	2.5	high_impact	0.24	0.9	8.38	36.17	0.34	N	0.61	polymorphism	0.9	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8704	8704	A	G	MI.378	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	178	60	M	V	Ata/Gta	-9.59	0	0	benign	0	neutral	0.55	neutral	4.48	neutral	1.62	neutral	0.03	neutral_impact	0.24	0.99	neutral	0.94	neutral	-0.61	0.12	neutral	0.84	0.85	NA	NA	0.37	neutral	0.52	disease	0.32	neutral	4	0.45	neutral	0.78	deleterious	-6	neutral	0.15	neutral	2.09	high_impact	0.34	medium_impact	-0.89	medium_impact	0.43	0.9	26.99	19.59	0.37	N	0.30	polymorphism	1	0.01	rs878852994	Uncertain_significance	not_provided	236947	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6793	6793	T	A	MI.3780	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	890	297	M	K	aTa/aAa	1.98	0.87	0	probably_damaging	0.95	deleterious	0	neutral	2.85	deleterious	-3.18	deleterious	-3.8	high_impact	4.39	0.62	neutral	0.1	damaging	4.36	24.10	deleterious	0.21	0.55	0.44	neutral	0.93	disease	0.76	disease	0.78	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.84	deleterious	-1.96	low_impact	-1.48	low_impact	2.95	high_impact	0.33	0.9	8.38	36.17	0.47	N	0.73	polymorphism	0.54	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6794	6794	A	T	MI.3781	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	891	297	M	I	atA/atT	4.76	0.97	0	probably_damaging	0.92	deleterious	0	neutral	2.95	neutral	-0.02	neutral	-2.33	medium_impact	3.42	0.63	neutral	0.13	damaging	3.59	23.20	deleterious	0.53	0.6	0.24	neutral	0.89	disease	0.38	neutral	0.63	disease	3	1	deleterious	0.04	neutral	5	deleterious	0.75	deleterious	-1.76	low_impact	-1.48	low_impact	2.06	high_impact	0.56	0.9	8.38	36.17	0.46	N	0.31	disease_causing	0.94	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6794	6794	A	C	MI.3782	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	891	297	M	I	atA/atC	4.76	0.97	0	probably_damaging	0.92	deleterious	0	neutral	2.95	neutral	-0.02	neutral	-2.33	medium_impact	3.42	0.63	neutral	0.13	damaging	3.45	23.00	deleterious	0.53	0.6	0.24	neutral	0.89	disease	0.38	neutral	0.63	disease	3	1	deleterious	0.04	neutral	5	deleterious	0.75	deleterious	-1.76	low_impact	-1.48	low_impact	2.06	high_impact	0.56	0.9	8.38	36.17	0.46	N	0.31	disease_causing	0.94	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6795	6795	G	T	MI.3783	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	892	298	D	Y	Gac/Tac	-0.33	0.23	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-4.24	deleterious	-5.83	high_impact	5.17	0.58	damaging	0.05	damaging	3.97	23.60	deleterious	0.25	0.55	0.67	disease	0.95	disease	0.66	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.37	0.9	2.34	6.69	0.56	P	0.94	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6795	6795	G	A	MI.3784	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	892	298	D	N	Gac/Aac	-0.33	0.23	0	probably_damaging	0.99	deleterious	0.04	neutral	2.77	neutral	-1.87	deleterious	-3.19	medium_impact	3.08	0.54	damaging	0.12	damaging	4.25	23.90	deleterious	0.61	0.65	0.41	neutral	0.83	disease	0.27	neutral	0.45	neutral	1	1	deleterious	0.03	neutral	5	deleterious	0.81	deleterious	-2.64	low_impact	-0.58	medium_impact	1.75	medium_impact	0.87	0.9	2.34	6.69	0.32	N	0.89	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6795	6795	G	C	MI.3785	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	892	298	D	H	Gac/Cac	-0.33	0.23	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.34	deleterious	-4.5	high_impact	4.82	0.58	damaging	0.04	damaging	3.70	23.30	deleterious	0.35	0.55	0.58	disease	0.89	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.61	0.9	2.34	6.69	0.6	P	0.97	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6796	6796	A	G	MI.3786	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	893	298	D	G	gAc/gGc	6.38	1	0	probably_damaging	0.99	deleterious	0	neutral	2.8	neutral	-1.41	deleterious	-4.54	high_impact	4.62	0.58	damaging	0.06	damaging	4.05	23.70	deleterious	0.26	0.55	0.35	neutral	0.92	disease	0.62	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	3.17	high_impact	0.39	0.9	2.34	6.69	0.47	P	0.85	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6796	6796	A	C	MI.3787	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	893	298	D	A	gAc/gCc	6.38	1	0	probably_damaging	0.99	deleterious	0	neutral	2.73	neutral	-2.67	deleterious	-5.17	high_impact	4.82	0.62	neutral	0.07	damaging	3.72	23.30	deleterious	0.26	0.55	0.36	neutral	0.86	disease	0.63	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.35	high_impact	0.49	0.9	2.34	6.69	0.64	P	0.85	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6796	6796	A	T	MI.3788	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	893	298	D	V	gAc/gTc	6.38	1	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-4.93	deleterious	-5.83	medium_impact	3.32	0.59	damaging	0.05	damaging	3.81	23.40	deleterious	0.24	0.55	0.25	neutral	0.94	disease	0.63	disease	0.77	disease	5	1	deleterious	0	neutral	5	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	1.97	medium_impact	0.40	0.9	2.34	6.69	0.38	N	0.93	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6797	6797	C	A	MI.3789	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	894	298	D	E	gaC/gaA	5.68	1	0	probably_damaging	0.94	deleterious	0	neutral	2.75	neutral	-2.19	deleterious	-2.52	high_impact	3.56	0.55	damaging	0.06	damaging	4.30	24.00	deleterious	0.46	0.55	0.29	neutral	0.83	disease	0.44	neutral	0.64	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.77	deleterious	-1.88	low_impact	-1.48	low_impact	2.19	high_impact	0.69	0.9	2.34	6.69	0.45	N	0.65	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8704	8704	A	T	MI.379	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	178	60	M	L	Ata/Tta	-9.59	0	0	benign	0	neutral	0.89	neutral	4.47	neutral	1.44	neutral	-0.56	neutral_impact	-0.76	0.95	neutral	0.85	neutral	0.38	6.44	deleterious	0.73	0.75	NA	NA	0.23	neutral	0.4	neutral	0.14	neutral	7	0.11	neutral	0.95	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.8	medium_impact	-1.75	low_impact	0.60	0.9	26.99	19.59	0.33	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6797	6797	C	G	MI.3790	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	894	298	D	E	gaC/gaG	5.68	1	0	probably_damaging	0.94	deleterious	0	neutral	2.75	neutral	-2.19	deleterious	-2.52	high_impact	3.56	0.55	damaging	0.06	damaging	3.94	23.50	deleterious	0.46	0.55	0.29	neutral	0.83	disease	0.44	neutral	0.64	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.77	deleterious	-1.88	low_impact	-1.48	low_impact	2.19	high_impact	0.69	0.9	2.34	6.69	0.44	N	0.65	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6798	6798	G	T	MI.3791	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	895	299	V	L	Gta/Tta	-1.72	0	0	probably_damaging	0.97	neutral	0.13	neutral	2.87	neutral	-0.52	neutral	-1.81	medium_impact	2.58	0.57	damaging	0.06	damaging	1.83	15.15	deleterious	0.41	0.55	0.41	neutral	0.73	disease	0.36	neutral	0.43	neutral	1	0.99	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-2.18	low_impact	-0.27	medium_impact	1.28	medium_impact	0.89	0.9	4.29	7.92	0.29	N	0.55	disease_causing	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6798	6798	G	C	MI.3792	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	895	299	V	L	Gta/Cta	-1.72	0	0	probably_damaging	0.97	neutral	0.13	neutral	2.87	neutral	-0.52	neutral	-1.81	medium_impact	2.58	0.57	damaging	0.06	damaging	1.73	14.58	neutral	0.41	0.55	0.41	neutral	0.73	disease	0.36	neutral	0.43	neutral	1	0.99	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-2.18	low_impact	-0.27	medium_impact	1.28	medium_impact	0.89	0.9	4.29	7.92	0.29	N	0.55	disease_causing	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6798	6798	G	A	MI.3793	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	895	299	V	M	Gta/Ata	-1.72	0	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-2.67	neutral	-1.89	high_impact	3.96	0.57	damaging	0.07	damaging	3.71	23.30	deleterious	0.4	0.55	0.67	disease	0.77	disease	0.39	neutral	0.56	disease	1	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.78	0.9	4.29	7.92	0.31	N	0.82	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6799	6799	T	C	MI.3794	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	896	299	V	A	gTa/gCa	5.22	1	0	probably_damaging	1	deleterious	0.03	neutral	2.86	neutral	-0.57	deleterious	-2.55	medium_impact	2.83	0.58	damaging	0.1	damaging	3.35	22.90	deleterious	0.34	0.55	0.32	neutral	0.64	disease	0.3	neutral	0.39	neutral	2	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-0.65	medium_impact	1.51	medium_impact	0.43	0.9	4.29	7.92	0.45	N	0.47	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6799	6799	T	A	MI.3795	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	896	299	V	E	gTa/gAa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-1.4	deleterious	-3.91	high_impact	4.58	0.56	damaging	0.08	damaging	4.69	24.60	deleterious	0.11	0.55	0.27	neutral	0.89	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.46	0.9	4.29	7.92	0.52	P	0.84	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6799	6799	T	G	MI.3796	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	896	299	V	G	gTa/gGa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.81	neutral	-2.38	deleterious	-4.55	high_impact	4.04	0.57	damaging	0.08	damaging	3.87	23.50	deleterious	0.15	0.55	0.43	neutral	0.87	disease	0.56	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.63	high_impact	0.54	0.9	4.29	7.92	0.43	N	0.71	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6801	6801	G	C	MI.3797	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	898	300	D	H	Gac/Cac	-8.89	0	0	probably_damaging	1	deleterious	0	neutral	2.83	deleterious	-3.02	deleterious	-4.56	high_impact	4.84	0.58	damaging	0.04	damaging	3.72	23.30	deleterious	0.35	0.55	0.61	disease	0.88	disease	0.69	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.56	0.9	1.36	6.75	0.63	P	0.97	polymorphism	0.74	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6801	6801	G	T	MI.3798	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	898	300	D	Y	Gac/Tac	-8.89	0	0	probably_damaging	1	deleterious	0	neutral	2.9	neutral	-1.06	deleterious	-5.88	high_impact	4.49	0.53	damaging	0.05	damaging	4.01	23.60	deleterious	0.29	0.55	0.57	disease	0.94	disease	0.64	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.05	high_impact	0.30	0.9	1.36	6.75	0.38	N	0.94	polymorphism	0.57	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6801	6801	G	A	MI.3799	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	898	300	D	N	Gac/Aac	-8.89	0	0	probably_damaging	0.99	deleterious	0.02	neutral	2.85	neutral	-2.19	deleterious	-3.22	high_impact	3.8	0.48	damaging	0.05	damaging	4.30	24.00	deleterious	0.56	0.6	0.34	neutral	0.83	disease	0.55	disease	0.49	neutral	0	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-0.75	medium_impact	2.41	high_impact	0.77	0.9	1.36	6.75	0.31	N	0.89	polymorphism	0.94	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8543	8543	T	C	MI.38	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	17	6	F	S	tTc/tCc	4.76	1	0	probably_damaging	0.97	deleterious	0.01	neutral	3.9	neutral	-1.89	deleterious	-6.56	medium_impact	3.32	0.77	neutral	0.66	neutral	4.15	23.80	deleterious	0.44	0.65	0.64	disease	0.74	disease	0.78	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-2.19	low_impact	-0.84	medium_impact	1.75	medium_impact	0.24	0.9	39.82	8.43	0.56	P	0.99	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8704	8704	A	C	MI.380	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	178	60	M	L	Ata/Cta	-9.59	0	0	benign	0	neutral	0.89	neutral	4.47	neutral	1.44	neutral	-0.56	neutral_impact	-0.76	0.95	neutral	0.85	neutral	0.20	4.63	deleterious	0.73	0.75	NA	NA	0.23	neutral	0.4	neutral	0.14	neutral	7	0.11	neutral	0.95	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.8	medium_impact	-1.75	low_impact	0.60	0.9	26.99	19.59	0.33	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6802	6802	A	G	MI.3800	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	899	300	D	G	gAc/gGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	-2.01	deleterious	-4.57	high_impact	4.49	0.58	damaging	0.06	damaging	4.05	23.70	deleterious	0.26	0.55	0.55	disease	0.91	disease	0.67	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.05	high_impact	0.47	0.9	1.36	6.75	0.5	P	0.85	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6802	6802	A	T	MI.3801	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	899	300	D	V	gAc/gTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.9	neutral	-1.02	deleterious	-5.89	high_impact	3.83	0.55	damaging	0.05	damaging	3.82	23.40	deleterious	0.25	0.55	0.17	neutral	0.94	disease	0.65	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.44	high_impact	0.28	0.9	1.36	6.75	0.45	N	0.93	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6802	6802	A	C	MI.3802	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	899	300	D	A	gAc/gCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.91	neutral	-0.86	deleterious	-5.23	high_impact	4.63	0.63	neutral	0.09	damaging	3.77	23.40	deleterious	0.3	0.55	0.25	neutral	0.85	disease	0.65	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.18	high_impact	0.37	0.9	1.36	6.75	0.5	P	0.85	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6803	6803	C	A	MI.3803	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	900	300	D	E	gaC/gaA	8.69	1	0	probably_damaging	0.97	deleterious	0	neutral	2.84	neutral	-2.3	deleterious	-2.61	high_impact	4.63	0.51	damaging	0.06	damaging	4.24	23.90	deleterious	0.44	0.55	0.4	neutral	0.82	disease	0.52	disease	0.62	disease	2	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-2.18	low_impact	-1.48	low_impact	3.18	high_impact	0.62	0.9	1.36	6.75	0.49	P	0.65	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6803	6803	C	G	MI.3804	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	900	300	D	E	gaC/gaG	8.69	1	0	probably_damaging	0.97	deleterious	0	neutral	2.84	neutral	-2.3	deleterious	-2.61	high_impact	4.63	0.51	damaging	0.06	damaging	3.92	23.50	deleterious	0.44	0.55	0.4	neutral	0.82	disease	0.52	disease	0.62	disease	2	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-2.18	low_impact	-1.48	low_impact	3.18	high_impact	0.62	0.9	1.36	6.75	0.49	P	0.65	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6804	6804	A	C	MI.3805	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	901	301	T	P	Aca/Cca	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-2.7	deleterious	-3.9	medium_impact	3.26	0.59	damaging	0.44	neutral	3.57	23.20	deleterious	0.14	0.55	0.72	disease	0.83	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	1.91	medium_impact	0.54	0.9	3.51	6.73	0.29	N	0.92	disease_causing	0.99	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6804	6804	A	G	MI.3806	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	901	301	T	A	Aca/Gca	-5.42	0	0	probably_damaging	0.97	deleterious	0	neutral	2.78	neutral	-0.37	deleterious	-3.21	high_impact	3.91	0.75	neutral	0.57	neutral	3.48	23.10	deleterious	0.6	0.65	0.21	neutral	0.67	disease	0.48	neutral	0.45	neutral	1	1	deleterious	0.02	neutral	6	deleterious	0.68	deleterious	-2.18	low_impact	-1.48	low_impact	2.51	high_impact	0.51	0.9	3.51	6.73	0.45	N	0.69	disease_causing	0.95	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6804	6804	A	T	MI.3807	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	901	301	T	S	Aca/Tca	-5.42	0	0	probably_damaging	0.97	neutral	0.19	neutral	2.76	neutral	-0.63	deleterious	-2.52	medium_impact	2.25	0.58	damaging	0.73	neutral	3.27	22.80	deleterious	0.44	0.55	0.32	neutral	0.7	disease	0.29	neutral	0.45	neutral	1	0.98	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-2.18	low_impact	-0.16	medium_impact	0.98	medium_impact	0.72	0.9	3.51	6.73	0.42	N	0.79	disease_causing	0.87	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6805	6805	C	T	MI.3808	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	902	301	T	M	aCa/aTa	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-1.36	deleterious	-3.89	high_impact	4.13	0.61	neutral	0.58	neutral	4.16	23.80	deleterious	0.34	0.55	0.57	disease	0.83	disease	0.49	neutral	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.61	0.9	3.51	6.73	0.49	P	0.96	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6805	6805	C	A	MI.3809	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	902	301	T	K	aCa/aAa	6.84	1	0	probably_damaging	0.99	deleterious	0	neutral	2.69	neutral	-2.54	deleterious	-3.88	high_impact	4.76	0.63	neutral	0.42	neutral	4.54	24.30	deleterious	0.23	0.55	0.46	neutral	0.89	disease	0.72	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.3	high_impact	0.56	0.9	3.51	6.73	0.71	P	0.88	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8705	8705	T	C	MI.381	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	179	60	M	T	aTa/aCa	4.99	0.98	0.01	benign	0	neutral	0.49	neutral	4.47	neutral	1.51	neutral	0.32	neutral_impact	-0.69	0.98	neutral	0.98	neutral	-0.64	0.10	neutral	0.61	0.7	NA	NA	0.38	neutral	0.45	neutral	0.14	neutral	7	0.51	neutral	0.75	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	0.28	medium_impact	-1.69	low_impact	0.13	0.9	26.99	19.59	0.53	P	0.04	polymorphism	1	0.01	rs878959404	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6807	6807	C	G	MI.3810	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	904	302	R	G	Cga/Gga	-8.43	0	0	benign	0.02	deleterious	0	neutral	2.79	neutral	-0.59	deleterious	-4.61	high_impact	4.38	0.57	damaging	0.04	damaging	2.42	18.92	deleterious	0.24	0.55	0.5	disease	0.85	disease	0.74	disease	0.73	disease	5	1	deleterious	0.49	deleterious	2	deleterious	0.29	neutral	0.83	medium_impact	-1.48	low_impact	2.95	high_impact	0.37	0.9	1.36	7.12	0.4	N	0.92	polymorphism	0.88	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6807	6807	C	T	MI.3811	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	904	302	R	W	Cga/Tga	-8.43	0	0	probably_damaging	1	deleterious	0	neutral	2.77	deleterious	-5.11	deleterious	-5.27	high_impact	5.19	0.5	damaging	0.03	damaging	5.32	25.80	deleterious	0.37	0.55	0.52	disease	0.88	disease	0.75	disease	0.74	disease	5	1	deleterious	0	deleterious	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.72	0.9	1.36	7.12	0.59	P	1.00	polymorphism	0.72	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6808	6808	G	T	MI.3812	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	905	302	R	L	cGa/cTa	5.68	1	0	possibly_damaging	0.88	deleterious	0	neutral	2.94	neutral	-1.42	deleterious	-4.61	high_impact	3.66	0.61	neutral	0.02	damaging	4.34	24.00	deleterious	0.26	0.55	0.38	neutral	0.9	disease	0.72	disease	0.67	disease	3	1	deleterious	0.06	neutral	5	deleterious	0.77	deleterious	-1.57	low_impact	-1.48	low_impact	2.28	high_impact	0.32	0.9	1.36	7.12	0.54	P	0.99	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6808	6808	G	C	MI.3813	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	905	302	R	P	cGa/cCa	5.68	1	0	probably_damaging	0.98	deleterious	0	neutral	2.78	neutral	-2.65	deleterious	-4.61	high_impact	4.49	0.44	damaging	0.03	damaging	4.34	24.00	deleterious	0.18	0.55	0.68	disease	0.87	disease	0.81	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.35	low_impact	-1.48	low_impact	3.05	high_impact	0.22	0.9	1.36	7.12	0.68	P	0.99	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6808	6808	G	A	MI.3814	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	905	302	R	Q	cGa/cAa	5.68	1	0	probably_damaging	0.95	deleterious	0	neutral	2.9	neutral	-0.98	deleterious	-2.63	high_impact	4.09	0.58	damaging	0.02	damaging	4.58	24.40	deleterious	0.46	0.55	0.4	neutral	0.78	disease	0.66	disease	0.47	neutral	1	1	deleterious	0.03	neutral	6	deleterious	0.76	deleterious	-1.96	low_impact	-1.48	low_impact	2.68	high_impact	0.79	0.9	1.36	7.12	0.56	P	0.99	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6810	6810	G	C	MI.3815	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	907	303	A	P	Gca/Cca	0.13	0.97	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.08	deleterious	-3.3	high_impact	3.7	0.54	damaging	0.15	damaging	1.99	16.13	deleterious	0.11	0.55	0.49	neutral	0.89	disease	0.76	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.32	high_impact	0.82	0.9	2.34	6.8	0.46	N	0.85	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6810	6810	G	T	MI.3816	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	907	303	A	S	Gca/Tca	0.13	0.97	0	probably_damaging	1	neutral	0.06	neutral	2.66	neutral	-1.36	neutral	-1.96	medium_impact	2.62	0.63	neutral	0.18	damaging	2.23	17.71	deleterious	0.36	0.55	0.31	neutral	0.87	disease	0.54	disease	0.51	disease	0	1	deleterious	0.03	neutral	1	deleterious	0.83	deleterious	-3.58	low_impact	-0.47	medium_impact	1.32	medium_impact	0.85	0.9	2.34	6.8	0.39	N	0.64	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6810	6810	G	A	MI.3817	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	907	303	A	T	Gca/Aca	0.13	0.97	0	probably_damaging	1	neutral	0.05	neutral	2.72	neutral	-0.67	deleterious	-2.63	high_impact	4.08	0.56	damaging	0.15	damaging	3.94	23.50	deleterious	0.44	0.55	0.36	neutral	0.86	disease	0.62	disease	0.7	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.84	deleterious	-3.58	low_impact	-0.52	medium_impact	2.67	high_impact	0.80	0.9	2.34	6.8	0.45	N	0.20	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6811	6811	C	T	MI.3818	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	908	303	A	V	gCa/gTa	7.3	1	0	probably_damaging	1	neutral	0.07	neutral	2.66	neutral	-1.25	deleterious	-2.64	high_impact	3.62	0.42	damaging	0.16	damaging	4.19	23.80	deleterious	0.33	0.55	0.3	neutral	0.9	disease	0.63	disease	0.7	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.82	deleterious	-3.58	low_impact	-0.43	medium_impact	2.24	high_impact	0.77	0.9	2.34	6.8	0.7	P	0.75	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6811	6811	C	A	MI.3819	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	908	303	A	E	gCa/gAa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-3.74	deleterious	-3.29	high_impact	5.12	0.57	damaging	0.16	damaging	4.53	24.30	deleterious	0.13	0.55	0.5	neutral	0.92	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.72	0.9	2.34	6.8	0.73	P	0.76	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8705	8705	T	A	MI.382	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	179	60	M	K	aTa/aAa	4.99	0.98	0.01	benign	0.04	neutral	0.3	neutral	4.44	neutral	1.11	neutral	-1.14	neutral_impact	0.38	0.83	neutral	0.44	neutral	1.93	15.76	deleterious	0.35	0.65	NA	NA	0.59	disease	0.55	disease	0.61	disease	2	0.68	neutral	0.63	deleterious	-6	neutral	0.23	neutral	0.55	medium_impact	0.08	medium_impact	-0.77	medium_impact	0.51	0.9	26.99	19.59	0.5	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6811	6811	C	G	MI.3820	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	908	303	A	G	gCa/gGa	7.3	1	0	probably_damaging	0.99	deleterious	0	neutral	2.58	deleterious	-3.14	deleterious	-2.63	high_impact	4.15	0.54	damaging	0.17	damaging	2.29	18.10	deleterious	0.31	0.55	0.47	neutral	0.87	disease	0.6	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	2.73	high_impact	0.84	0.9	2.34	6.8	0.5	P	0.56	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6813	6813	T	C	MI.3821	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	910	304	Y	H	Tat/Cat	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	2.7	deleterious	-3.03	deleterious	-3.28	high_impact	4.38	0.66	neutral	0.09	damaging	3.70	23.30	deleterious	0.31	0.55	0.67	disease	0.88	disease	0.79	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.43	0.9	2.34	6.64	0.46	N	0.61	polymorphism	0.92	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6813	6813	T	G	MI.3822	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	910	304	Y	D	Tat/Gat	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.25	deleterious	-6.55	high_impact	5.19	0.6	neutral	0.09	damaging	4.10	23.70	deleterious	0.17	0.55	0.75	disease	0.93	disease	0.8	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.35	0.9	2.34	6.64	0.64	P	0.98	polymorphism	0.6	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6813	6813	T	A	MI.3823	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	910	304	Y	N	Tat/Aat	-7.04	0	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-2.76	deleterious	-5.9	high_impact	5.19	0.58	damaging	0.11	damaging	4.15	23.80	deleterious	0.29	0.55	0.63	disease	0.91	disease	0.74	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.28	0.9	2.34	6.64	0.63	P	0.94	polymorphism	0.52	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6814	6814	A	C	MI.3824	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	911	304	Y	S	tAt/tCt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-1.29	deleterious	-5.89	high_impact	4.09	0.69	neutral	0.14	damaging	3.60	23.20	deleterious	0.25	0.55	0.38	neutral	0.92	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.68	high_impact	0.36	0.9	2.34	6.64	0.49	N	0.90	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6814	6814	A	T	MI.3825	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	911	304	Y	F	tAt/tTt	5.68	1	0	probably_damaging	0.98	neutral	0.1	neutral	2.94	neutral	1.15	deleterious	-2.62	medium_impact	2.9	0.54	damaging	0.1	damaging	3.28	22.80	deleterious	0.3	0.55	0.18	neutral	0.9	disease	0.64	disease	0.71	disease	4	0.99	deleterious	0.06	neutral	1	deleterious	0.77	deleterious	-2.35	low_impact	-0.34	medium_impact	1.58	medium_impact	0.49	0.9	2.34	6.64	0.49	P	0.50	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6814	6814	A	G	MI.3826	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	911	304	Y	C	tAt/tGt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-2.86	deleterious	-5.91	high_impact	5.19	0.51	damaging	0.1	damaging	3.43	23.00	deleterious	0.33	0.55	0.62	disease	0.92	disease	0.75	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.32	0.9	2.34	6.64	0.69	P	0.89	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6816	6816	T	G	MI.3827	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	913	305	F	V	Ttc/Gtc	-1.72	0	0	probably_damaging	1	deleterious	0.01	neutral	2.65	neutral	-2.48	deleterious	-4.62	high_impact	5.27	0.71	neutral	0.07	damaging	4.28	24.00	deleterious	0.21	0.55	0.62	disease	0.91	disease	0.78	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-0.92	medium_impact	3.77	high_impact	0.58	0.9	1.75	6.66	0.72	P	0.84	polymorphism	0.53	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6816	6816	T	C	MI.3828	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	913	305	F	L	Ttc/Ctc	-1.72	0	0	probably_damaging	0.99	deleterious	0	neutral	2.67	neutral	-2.48	deleterious	-3.96	high_impact	4.58	0.84	neutral	0.05	damaging	4.29	24.00	deleterious	0.36	0.55	0.57	disease	0.84	disease	0.69	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.13	high_impact	0.73	0.9	1.75	6.66	0.39	N	0.83	polymorphism	0.69	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6816	6816	T	A	MI.3829	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	913	305	F	I	Ttc/Atc	-1.72	0	0	probably_damaging	0.99	deleterious	0	neutral	2.65	neutral	-2.58	deleterious	-3.96	high_impact	4.92	0.73	neutral	0.08	damaging	4.67	24.50	deleterious	0.19	0.55	0.49	neutral	0.88	disease	0.77	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	3.44	high_impact	0.65	0.9	1.75	6.66	0.73	P	0.88	polymorphism	0.71	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8706	8706	A	C	MI.383	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	180	60	M	I	atA/atC	2.21	0.98	0.01	benign	0.01	neutral	0.5	neutral	4.39	neutral	0.01	neutral	-0.38	neutral_impact	-1.04	0.88	neutral	0.97	neutral	-0.15	1.40	neutral	0.77	0.8	NA	NA	0.32	neutral	0.51	disease	0.23	neutral	5	0.49	neutral	0.75	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	0.29	medium_impact	-1.99	low_impact	0.56	0.9	26.99	19.59	0.46	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6817	6817	T	A	MI.3830	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	914	305	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.63	deleterious	-4.3	neutral	-1.98	high_impact	3.92	0.69	neutral	0.06	damaging	4.27	23.90	deleterious	0.21	0.55	0.49	neutral	0.82	disease	0.71	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.52	high_impact	0.73	0.9	1.75	6.66	0.54	P	0.59	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6817	6817	T	C	MI.3831	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	914	305	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.48	deleterious	-5.29	high_impact	4.12	0.73	neutral	0.08	damaging	4.34	24.00	deleterious	0.15	0.55	0.74	disease	0.89	disease	0.75	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.55	0.9	1.75	6.66	0.54	P	0.84	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6817	6817	T	G	MI.3832	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	914	305	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-5.32	deleterious	-5.29	high_impact	5.27	0.69	neutral	0.05	damaging	4.18	23.80	deleterious	0.17	0.55	0.89	disease	0.88	disease	0.77	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.41	0.9	1.75	6.66	0.69	P	0.91	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6818	6818	C	G	MI.3833	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	915	305	F	L	ttC/ttG	5.91	1	0	probably_damaging	0.99	deleterious	0	neutral	2.67	neutral	-2.48	deleterious	-3.96	high_impact	4.58	0.84	neutral	0.05	damaging	4.42	24.20	deleterious	0.36	0.55	0.57	disease	0.84	disease	0.69	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.13	high_impact	0.73	0.9	1.75	6.66	0.54	P	0.83	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6818	6818	C	A	MI.3834	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	915	305	F	L	ttC/ttA	5.91	1	0	probably_damaging	0.99	deleterious	0	neutral	2.67	neutral	-2.48	deleterious	-3.96	high_impact	4.58	0.84	neutral	0.05	damaging	4.71	24.60	deleterious	0.36	0.55	0.57	disease	0.84	disease	0.69	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.13	high_impact	0.73	0.9	1.75	6.66	0.54	P	0.83	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6819	6819	A	T	MI.3835	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	916	306	T	S	Acc/Tcc	-3.57	0	0	probably_damaging	0.98	neutral	0.18	neutral	2.86	neutral	0.36	deleterious	-2.52	medium_impact	2.17	0.64	neutral	0.08	damaging	3.33	22.90	deleterious	0.41	0.55	0.17	neutral	0.71	disease	0.39	neutral	0.35	neutral	3	0.99	deleterious	0.1	neutral	1	deleterious	0.71	deleterious	-2.35	low_impact	-0.17	medium_impact	0.91	medium_impact	0.78	0.9	2.73	6.69	0.27	N	0.79	disease_causing	0.92	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6819	6819	A	C	MI.3836	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	916	306	T	P	Acc/Ccc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.86	deleterious	-3.9	high_impact	5.11	0.5	damaging	0.08	damaging	3.57	23.10	deleterious	0.15	0.55	0.66	disease	0.85	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.62	0.9	2.73	6.69	0.69	P	0.92	disease_causing	0.99	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6819	6819	A	G	MI.3837	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	916	306	T	A	Acc/Gcc	-3.57	0	0	probably_damaging	0.98	deleterious	0	neutral	2.7	neutral	-1.06	deleterious	-3.22	high_impact	3.61	0.69	neutral	0.06	damaging	3.57	23.20	deleterious	0.42	0.55	0.34	neutral	0.67	disease	0.66	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.71	deleterious	-2.35	low_impact	-1.48	low_impact	2.23	high_impact	0.63	0.9	2.73	6.69	0.31	N	0.69	disease_causing	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6820	6820	C	T	MI.3838	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	917	306	T	I	aCc/aTc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-0.79	deleterious	-3.91	high_impact	4.3	0.64	neutral	0.04	damaging	4.10	23.70	deleterious	0.28	0.55	0.41	neutral	0.9	disease	0.65	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.87	high_impact	0.76	0.9	2.73	6.69	0.48	P	0.92	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6820	6820	C	G	MI.3839	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	917	306	T	S	aCc/aGc	7.07	1	0	probably_damaging	0.98	neutral	0.18	neutral	2.86	neutral	0.36	deleterious	-2.52	medium_impact	2.17	0.64	neutral	0.08	damaging	3.57	23.20	deleterious	0.41	0.55	0.17	neutral	0.71	disease	0.39	neutral	0.35	neutral	3	0.99	deleterious	0.1	neutral	1	deleterious	0.71	deleterious	-2.35	low_impact	-0.17	medium_impact	0.91	medium_impact	0.78	0.9	2.73	6.69	0.47	N	0.79	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8706	8706	A	T	MI.384	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	180	60	M	I	atA/atT	2.21	0.98	0.01	benign	0.01	neutral	0.5	neutral	4.39	neutral	0.01	neutral	-0.38	neutral_impact	-1.04	0.88	neutral	0.97	neutral	-0.11	1.68	neutral	0.77	0.8	NA	NA	0.32	neutral	0.51	disease	0.23	neutral	5	0.49	neutral	0.75	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	0.29	medium_impact	-1.99	low_impact	0.56	0.9	26.99	19.59	0.46	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6820	6820	C	A	MI.3840	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	917	306	T	N	aCc/aAc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-2.39	deleterious	-3.22	high_impact	5.11	0.58	damaging	0.05	damaging	3.80	23.40	deleterious	0.32	0.55	0.54	disease	0.85	disease	0.66	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.77	0.9	2.73	6.69	0.7	P	0.80	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6822	6822	T	A	MI.3841	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	919	307	S	T	Tcc/Acc	-3.57	0	0	probably_damaging	0.95	deleterious	0.02	neutral	2.81	neutral	-0.01	neutral	-1.25	medium_impact	2.62	0.5	damaging	0.08	damaging	3.85	23.40	deleterious	0.28	0.55	0.25	neutral	0.57	disease	0.38	neutral	0.41	neutral	2	1	deleterious	0.04	neutral	5	deleterious	0.68	deleterious	-1.96	low_impact	-0.75	medium_impact	1.32	medium_impact	0.89	0.9	2.53	6.65	0.34	N	0.43	disease_causing	0.99	0.03	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6822	6822	T	C	MI.3842	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	919	307	S	P	Tcc/Ccc	-3.57	0	0	probably_damaging	0.99	deleterious	0	neutral	2.71	neutral	-2.1	neutral	-2.26	high_impact	4.62	0.44	damaging	0.05	damaging	4.08	23.70	deleterious	0.18	0.55	0.64	disease	0.86	disease	0.72	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.64	low_impact	-1.48	low_impact	3.17	high_impact	0.78	0.9	2.53	6.65	0.51	P	0.91	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6822	6822	T	G	MI.3843	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	919	307	S	A	Tcc/Gcc	-3.57	0	0	probably_damaging	0.97	neutral	0.63	neutral	2.86	neutral	0.5	neutral	0.01	neutral_impact	0.29	0.53	damaging	0.19	damaging	1.84	15.25	deleterious	0.45	0.55	0.17	neutral	0.09	neutral	0.28	neutral	0.21	neutral	6	0.97	neutral	0.33	neutral	-2	neutral	0.60	deleterious	-2.18	low_impact	0.32	medium_impact	-0.83	medium_impact	0.74	0.9	2.53	6.65	0.33	N	0.35	disease_causing	0.95	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6823	6823	C	T	MI.3844	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	920	307	S	F	tCc/tTc	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.81	neutral	-0.03	deleterious	-2.92	medium_impact	2.86	0.49	damaging	0.04	damaging	4.35	24.10	deleterious	0.2	0.55	0.31	neutral	0.84	disease	0.56	disease	0.46	neutral	1	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	1.54	medium_impact	0.55	0.9	2.53	6.65	0.4	N	0.98	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6823	6823	C	G	MI.3845	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	920	307	S	C	tCc/tGc	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-2.94	neutral	-1.96	high_impact	4.27	0.48	damaging	0.02	damaging	3.68	23.30	deleterious	0.27	0.55	0.62	disease	0.79	disease	0.58	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.84	high_impact	0.78	0.9	2.53	6.65	0.46	N	0.85	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6823	6823	C	A	MI.3846	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	920	307	S	Y	tCc/tAc	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-1.95	deleterious	-2.92	high_impact	3.92	0.47	damaging	0.04	damaging	4.14	23.80	deleterious	0.22	0.55	0.39	neutral	0.82	disease	0.63	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.52	high_impact	0.75	0.9	2.53	6.65	0.46	N	0.92	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6825	6825	G	C	MI.3847	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	922	308	A	P	Gct/Cct	-11.21	0	0	possibly_damaging	0.9	deleterious	0	neutral	2.76	deleterious	-3.48	deleterious	-3.3	high_impact	5.11	0.52	damaging	0.47	neutral	3.98	23.60	deleterious	0.14	0.55	0.3	neutral	0.89	disease	0.63	disease	0.7	disease	4	1	deleterious	0.05	neutral	5	deleterious	0.80	deleterious	-1.65	low_impact	-1.48	low_impact	3.62	high_impact	0.79	0.9	2.34	7.25	0.65	P	0.85	polymorphism	0.72	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6825	6825	G	A	MI.3848	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	922	308	A	T	Gct/Act	-11.21	0	0	benign	0.06	deleterious	0	neutral	2.83	neutral	-1.56	deleterious	-2.63	medium_impact	3.08	0.56	damaging	0.44	neutral	4.32	24.00	deleterious	0.44	0.55	0.28	neutral	0.84	disease	0.54	disease	0.58	disease	2	1	deleterious	0.47	deleterious	1	deleterious	0.27	neutral	0.37	medium_impact	-1.48	low_impact	1.75	medium_impact	0.75	0.9	2.34	7.25	0.4	N	0.20	polymorphism	0.9	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6825	6825	G	T	MI.3849	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	922	308	A	S	Gct/Tct	-11.21	0	0	possibly_damaging	0.63	deleterious	0	neutral	2.8	neutral	-2.13	neutral	-1.98	high_impact	3.9	0.67	neutral	0.56	neutral	3.79	23.40	deleterious	0.35	0.55	0.34	neutral	0.87	disease	0.52	disease	0.68	disease	4	1	deleterious	0.19	neutral	5	deleterious	0.46	deleterious	-0.97	medium_impact	-1.48	low_impact	2.5	high_impact	0.81	0.9	2.34	7.25	0.47	N	0.64	polymorphism	0.95	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8707	8707	C	A	MI.385	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	181	61	H	N	Cac/Aac	-12.83	0	0	probably_damaging	0.98	neutral	0.07	neutral	4.38	neutral	-0.55	deleterious	-3.82	neutral_impact	0.44	0.89	neutral	0.1	damaging	3.76	23.30	deleterious	0.58	0.7	0.38	neutral	0.44	neutral	0.68	disease	0.49	neutral	0	0.99	deleterious	0.05	neutral	-2	neutral	0.70	deleterious	-2.36	low_impact	-0.34	medium_impact	-0.72	medium_impact	0.49	0.9	48.67	8.33	0.38	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6826	6826	C	T	MI.3850	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	923	308	A	V	gCt/gTt	9.15	1	0	possibly_damaging	0.5	neutral	0.11	neutral	2.87	neutral	-1.07	deleterious	-2.63	medium_impact	2.4	0.4	damaging	0.48	neutral	4.47	24.20	deleterious	0.4	0.55	0.36	neutral	0.87	disease	0.45	neutral	0.38	neutral	2	0.88	neutral	0.31	neutral	0	NA	0.64	deleterious	-0.76	medium_impact	-0.31	medium_impact	1.12	medium_impact	0.79	0.9	2.34	7.25	0.77	P	0.75	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6826	6826	C	A	MI.3851	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	923	308	A	D	gCt/gAt	9.15	1	0	possibly_damaging	0.87	deleterious	0	neutral	2.76	deleterious	-3.7	deleterious	-3.95	high_impact	5.11	0.6	damaging	0.44	neutral	4.53	24.30	deleterious	0.14	0.55	0.68	disease	0.93	disease	0.73	disease	0.75	disease	5	1	deleterious	0.07	neutral	5	deleterious	0.83	deleterious	-1.53	low_impact	-1.48	low_impact	3.62	high_impact	0.74	0.9	2.34	7.25	0.72	P	0.89	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6826	6826	C	G	MI.3852	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	923	308	A	G	gCt/gGt	9.15	1	0	benign	0.38	deleterious	0	neutral	2.77	deleterious	-3.28	deleterious	-2.64	high_impact	4.55	0.57	damaging	0.57	neutral	4.06	23.70	deleterious	0.31	0.55	0.64	disease	0.85	disease	0.62	disease	0.68	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.45	deleterious	-0.56	medium_impact	-1.48	low_impact	3.1	high_impact	0.82	0.9	2.34	7.25	0.54	P	0.56	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6828	6828	A	C	MI.3853	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	925	309	T	P	Acc/Ccc	-8.89	0	0	probably_damaging	1	deleterious	0	neutral	2.12	deleterious	-6.46	deleterious	-3.94	high_impact	4.91	0.62	neutral	0.09	damaging	4.04	23.70	deleterious	0.2	0.55	0.88	disease	0.83	disease	0.75	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.52	0.9	2.14	6.7	0.64	P	0.92	polymorphism	0.73	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6828	6828	A	T	MI.3854	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	925	309	T	S	Acc/Tcc	-8.89	0	0	probably_damaging	0.99	deleterious	0.03	neutral	2.64	neutral	-0.93	deleterious	-2.63	medium_impact	3.39	0.74	neutral	0.08	damaging	3.92	23.50	deleterious	0.37	0.55	0.46	neutral	0.75	disease	0.65	disease	0.6	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-2.64	low_impact	-0.65	medium_impact	2.03	high_impact	0.57	0.9	2.14	6.7	0.28	N	0.79	polymorphism	0.98	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6828	6828	A	G	MI.3855	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	925	309	T	A	Acc/Gcc	-8.89	0	0	probably_damaging	0.99	deleterious	0	neutral	2.15	deleterious	-4.64	deleterious	-3.29	high_impact	5.25	0.75	neutral	0.07	damaging	4.07	23.70	deleterious	0.47	0.55	0.66	disease	0.64	disease	0.72	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.64	low_impact	-1.48	low_impact	3.75	high_impact	0.43	0.9	2.14	6.7	0.62	P	0.69	polymorphism	0.93	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6829	6829	C	T	MI.3856	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	926	309	T	I	aCc/aTc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.11	deleterious	-6.97	deleterious	-3.95	high_impact	4.91	0.71	neutral	0.06	damaging	4.04	23.70	deleterious	0.32	0.55	0.89	disease	0.88	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.63	0.9	2.14	6.7	0.71	P	0.92	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6829	6829	C	G	MI.3857	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	926	309	T	S	aCc/aGc	7.07	1	0	probably_damaging	0.99	deleterious	0.03	neutral	2.64	neutral	-0.93	deleterious	-2.63	medium_impact	3.39	0.74	neutral	0.08	damaging	3.59	23.20	deleterious	0.37	0.55	0.46	neutral	0.75	disease	0.65	disease	0.6	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-2.64	low_impact	-0.65	medium_impact	2.03	high_impact	0.57	0.9	2.14	6.7	0.49	N	0.79	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6829	6829	C	A	MI.3858	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	926	309	T	N	aCc/aAc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.13	deleterious	-5.46	deleterious	-3.29	high_impact	4.91	0.69	neutral	0.06	damaging	3.71	23.30	deleterious	0.43	0.55	0.83	disease	0.85	disease	0.76	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.80	0.9	2.14	6.7	0.71	P	0.80	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6831	6831	A	G	MI.3859	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	928	310	M	V	Ata/Gta	-10.28	0	0	probably_damaging	0.94	deleterious	0	neutral	2.69	neutral	-1.42	deleterious	-2.63	high_impact	4.28	0.59	damaging	0.1	damaging	2.95	22.10	deleterious	0.43	0.55	0.43	neutral	0.85	disease	0.66	disease	0.71	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-1.88	low_impact	-1.48	low_impact	2.85	high_impact	0.36	0.9	2.34	6.69	0.36	N	0.88	polymorphism	0.99	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8707	8707	C	T	MI.386	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	181	61	H	Y	Cac/Tac	-12.83	0	0	probably_damaging	0.98	neutral	0.26	neutral	4.41	neutral	0.74	deleterious	-2.57	neutral_impact	0.39	0.96	neutral	0.12	damaging	3.57	23.10	deleterious	0.62	0.7	0.45	neutral	0.45	neutral	0.69	disease	0.5	disease	0	0.98	deleterious	0.14	neutral	-2	neutral	0.68	deleterious	-2.36	low_impact	0.04	medium_impact	-0.76	medium_impact	0.23	0.9	48.67	8.33	0.33	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6831	6831	A	C	MI.3860	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	928	310	M	L	Ata/Cta	-10.28	0	0	possibly_damaging	0.9	deleterious	0.04	neutral	2.71	neutral	0.1	neutral	-1.97	medium_impact	3.42	0.64	neutral	0.1	damaging	3.44	23.00	deleterious	0.41	0.55	0.25	neutral	0.78	disease	0.53	disease	0.24	neutral	5	0.99	deleterious	0.07	neutral	4	deleterious	0.67	deleterious	-1.65	low_impact	-0.58	medium_impact	2.06	high_impact	0.41	0.9	2.34	6.69	0.33	N	0.61	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6831	6831	A	T	MI.3861	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	928	310	M	L	Ata/Tta	-10.28	0	0	possibly_damaging	0.9	deleterious	0.04	neutral	2.71	neutral	0.1	neutral	-1.97	medium_impact	3.42	0.64	neutral	0.1	damaging	3.63	23.20	deleterious	0.41	0.55	0.25	neutral	0.78	disease	0.53	disease	0.24	neutral	5	0.99	deleterious	0.07	neutral	4	deleterious	0.67	deleterious	-1.65	low_impact	-0.58	medium_impact	2.06	high_impact	0.41	0.9	2.34	6.69	0.33	N	0.61	polymorphism	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6832	6832	T	C	MI.3862	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	929	310	M	T	aTa/aCa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-2.42	deleterious	-3.94	high_impact	4.62	0.63	neutral	0.11	damaging	3.09	22.50	deleterious	0.33	0.55	0.61	disease	0.86	disease	0.7	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.26	0.9	2.34	6.69	0.54	P	0.79	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6832	6832	T	A	MI.3863	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	929	310	M	K	aTa/aAa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.81	deleterious	-3.94	high_impact	5.17	0.57	damaging	0.06	damaging	4.09	23.70	deleterious	0.19	0.55	0.77	disease	0.91	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.35	0.9	2.34	6.69	0.75	P	0.93	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6833	6833	A	C	MI.3864	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	930	310	M	I	atA/atC	5.91	1	0	probably_damaging	0.96	deleterious	0.01	neutral	2.64	neutral	-1.37	deleterious	-2.62	medium_impact	3.43	0.52	damaging	0.1	damaging	3.52	23.10	deleterious	0.43	0.55	0.32	neutral	0.82	disease	0.65	disease	0.57	disease	1	1	deleterious	0.03	neutral	5	deleterious	0.78	deleterious	-2.06	low_impact	-0.92	medium_impact	2.07	high_impact	0.43	0.9	2.34	6.69	0.47	N	0.87	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6833	6833	A	T	MI.3865	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	930	310	M	I	atA/atT	5.91	1	0	probably_damaging	0.96	deleterious	0.01	neutral	2.64	neutral	-1.37	deleterious	-2.62	medium_impact	3.43	0.52	damaging	0.1	damaging	3.58	23.20	deleterious	0.43	0.55	0.32	neutral	0.82	disease	0.65	disease	0.57	disease	1	1	deleterious	0.03	neutral	5	deleterious	0.78	deleterious	-2.06	low_impact	-0.92	medium_impact	2.07	high_impact	0.43	0.9	2.34	6.69	0.5	P	0.87	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6834	6834	A	T	MI.3866	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	931	311	I	F	Atc/Ttc	4.06	1	0	probably_damaging	0.99	deleterious	0	neutral	2.69	neutral	-1.97	deleterious	-2.57	high_impact	4.07	0.6	damaging	0.1	damaging	3.85	23.40	deleterious	0.37	0.55	0.51	disease	0.89	disease	0.52	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	2.66	high_impact	0.73	0.9	1.36	6.72	0.47	N	0.85	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6834	6834	A	G	MI.3867	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	931	311	I	V	Atc/Gtc	4.06	1	0	possibly_damaging	0.84	neutral	0.24	neutral	2.8	neutral	-0.76	neutral	-0.48	low_impact	1.5	0.56	damaging	0.26	damaging	1.93	15.76	deleterious	0.56	0.6	0.28	neutral	0.33	neutral	0.34	neutral	0.38	neutral	2	0.89	neutral	0.2	neutral	-3	neutral	0.54	deleterious	-1.43	low_impact	-0.09	medium_impact	0.29	medium_impact	0.59	0.9	1.36	6.72	0.59	P	0.23	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6834	6834	A	C	MI.3868	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	931	311	I	L	Atc/Ctc	4.06	1	0	probably_damaging	0.94	neutral	0.05	neutral	3.01	neutral	-0.16	neutral	-1.27	medium_impact	2.34	0.63	neutral	0.13	damaging	3.87	23.50	deleterious	0.38	0.55	0.18	neutral	0.76	disease	0.46	neutral	0.51	disease	0	0.99	deleterious	0.06	neutral	1	deleterious	0.57	deleterious	-1.88	low_impact	-0.52	medium_impact	1.06	medium_impact	0.69	0.9	1.36	6.72	0.49	N	0.61	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6835	6835	T	A	MI.3869	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	932	311	I	N	aTc/aAc	7.07	1	0	probably_damaging	1	deleterious	0.01	neutral	2.66	deleterious	-4.13	deleterious	-4.38	high_impact	4.42	0.61	neutral	0.12	damaging	4.67	24.50	deleterious	0.32	0.55	0.68	disease	0.9	disease	0.61	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-0.92	medium_impact	2.98	high_impact	0.67	0.9	1.36	6.72	0.48	P	0.94	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8707	8707	C	G	MI.387	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	181	61	H	D	Cac/Gac	-12.83	0	0	probably_damaging	0.99	neutral	0.06	neutral	4.37	neutral	-1.39	deleterious	-5.17	low_impact	1.59	0.88	neutral	0.09	damaging	3.76	23.30	deleterious	0.38	0.65	0.5	neutral	0.6	disease	0.77	disease	0.76	disease	5	1	deleterious	0.04	neutral	-2	neutral	0.75	deleterious	-2.65	low_impact	-0.38	medium_impact	0.27	medium_impact	0.58	0.9	48.67	8.33	0.33	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6835	6835	T	G	MI.3870	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	932	311	I	S	aTc/aGc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-2.51	deleterious	-3.72	high_impact	4.27	0.69	neutral	0.18	damaging	4.38	24.10	deleterious	0.27	0.55	0.51	disease	0.92	disease	0.61	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.84	high_impact	0.59	0.9	1.36	6.72	0.48	N	0.62	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6835	6835	T	C	MI.3871	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	932	311	I	T	aTc/aCc	7.07	1	0	probably_damaging	1	deleterious	0.01	neutral	2.73	neutral	-2.22	deleterious	-2.95	high_impact	3.87	0.64	neutral	0.14	damaging	3.55	23.10	deleterious	0.5	0.6	0.35	neutral	0.81	disease	0.52	disease	0.59	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-0.92	medium_impact	2.47	high_impact	0.55	0.9	1.36	6.72	0.43	N	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6836	6836	C	G	MI.3872	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	933	311	I	M	atC/atG	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-1.81	neutral	-1.84	high_impact	3.61	0.65	neutral	0.15	damaging	3.46	23.00	deleterious	0.54	0.6	0.39	neutral	0.77	disease	0.5	neutral	0.57	disease	1	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.76	0.9	1.36	6.72	0.43	N	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6836	6836	C	A	MI.3873	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	933	311	I	M	atC/atA	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-1.81	neutral	-1.84	high_impact	3.61	0.65	neutral	0.15	damaging	3.96	23.60	deleterious	0.54	0.6	0.39	neutral	0.77	disease	0.5	neutral	0.57	disease	1	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.76	0.9	1.36	6.72	0.44	N	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6837	6837	A	C	MI.3874	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	934	312	I	L	Atc/Ctc	-1.03	0.02	0	probably_damaging	0.98	deleterious	0	neutral	2.57	neutral	-2.41	neutral	-1.31	high_impact	4.92	0.64	neutral	0.09	damaging	3.92	23.50	deleterious	0.31	0.55	0.62	disease	0.77	disease	0.57	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.54	deleterious	-2.35	low_impact	-1.48	low_impact	3.44	high_impact	0.68	0.9	3.9	6.77	0.64	P	0.61	disease_causing	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6837	6837	A	T	MI.3875	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	934	312	I	F	Atc/Ttc	-1.03	0.02	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-4.74	deleterious	-2.62	high_impact	4.92	0.58	damaging	0.08	damaging	3.84	23.40	deleterious	0.23	0.55	0.86	disease	0.9	disease	0.63	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.71	0.9	3.9	6.77	0.64	P	0.85	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6837	6837	A	G	MI.3876	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	934	312	I	V	Atc/Gtc	-1.03	0.02	0	probably_damaging	0.95	deleterious	0	neutral	2.61	neutral	-1.22	neutral	-0.66	high_impact	3.86	0.61	neutral	0.12	damaging	3.16	22.60	deleterious	0.42	0.55	0.28	neutral	0.66	disease	0.58	disease	0.64	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.55	deleterious	-1.96	low_impact	-1.48	low_impact	2.47	high_impact	0.68	0.9	3.9	6.77	0.41	N	0.23	disease_causing	0.95	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6838	6838	T	G	MI.3877	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	935	312	I	S	aTc/aGc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.45	deleterious	-5.5	deleterious	-3.93	high_impact	5.28	0.61	neutral	0.13	damaging	4.41	24.10	deleterious	0.17	0.55	0.88	disease	0.92	disease	0.68	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.46	0.9	3.9	6.77	0.7	P	0.62	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6838	6838	T	C	MI.3878	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	935	312	I	T	aTc/aCc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.45	deleterious	-4.51	deleterious	-3.27	high_impact	4.58	0.6	neutral	0.09	damaging	3.54	23.10	deleterious	0.29	0.55	0.81	disease	0.83	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.56	0.9	3.9	6.77	0.49	P	0.76	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6838	6838	T	A	MI.3879	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	935	312	I	N	aTc/aAc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-6.67	deleterious	-4.59	high_impact	5.28	0.58	damaging	0.09	damaging	4.58	24.40	deleterious	0.14	0.55	0.8	disease	0.9	disease	0.69	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.78	high_impact	0.50	0.9	3.9	6.77	0.66	P	0.94	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8708	8708	A	T	MI.388	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	182	61	H	L	cAc/cTc	-0.33	0	0	probably_damaging	0.99	neutral	1	neutral	4.61	neutral	2.99	deleterious	-3.73	neutral_impact	-2.02	0.78	neutral	0.46	neutral	0.89	10.03	neutral	0.41	0.65	0.4	neutral	0.25	neutral	0.53	disease	0.46	neutral	1	0.99	deleterious	0.51	deleterious	-2	neutral	0.67	deleterious	-2.65	low_impact	1.98	high_impact	-2.83	low_impact	0.31	0.9	48.67	8.33	0.25	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6839	6839	C	A	MI.3880	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	936	312	I	M	atC/atA	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-5.08	neutral	-1.97	high_impact	4.72	0.63	neutral	0.09	damaging	3.95	23.60	deleterious	0.28	0.55	0.83	disease	0.78	disease	0.61	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.76	0.9	3.9	6.77	0.66	P	0.76	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6839	6839	C	G	MI.3881	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	936	312	I	M	atC/atG	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-5.08	neutral	-1.97	high_impact	4.72	0.63	neutral	0.09	damaging	3.46	23.00	deleterious	0.28	0.55	0.83	disease	0.78	disease	0.61	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.76	0.9	3.9	6.77	0.66	P	0.76	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6840	6840	G	C	MI.3882	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	937	313	A	P	Gct/Cct	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.47	deleterious	-5.23	deleterious	-3.3	high_impact	5.24	0.58	damaging	0.15	damaging	3.87	23.50	deleterious	0.13	0.55	0.84	disease	0.9	disease	0.67	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.76	0.9	4.29	6.68	0.66	P	0.85	polymorphism	0.63	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6840	6840	G	T	MI.3883	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	937	313	A	S	Gct/Tct	-3.11	0	0	probably_damaging	0.99	deleterious	0	neutral	2.51	neutral	-2.09	neutral	-1.98	high_impact	3.55	0.73	neutral	0.17	damaging	3.77	23.40	deleterious	0.27	0.55	0.32	neutral	0.89	disease	0.64	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	2.18	high_impact	0.78	0.9	4.29	6.68	0.35	N	0.64	polymorphism	0.93	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6840	6840	G	A	MI.3884	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	937	313	A	T	Gct/Act	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.3	deleterious	-2.64	high_impact	4.88	0.65	neutral	0.15	damaging	4.28	24.00	deleterious	0.35	0.55	0.68	disease	0.87	disease	0.62	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.41	high_impact	0.73	0.9	4.29	6.68	0.7	P	0.20	polymorphism	0.86	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6841	6841	C	G	MI.3885	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	938	313	A	G	gCt/gGt	4.52	1	0	probably_damaging	0.98	neutral	0.06	neutral	2.45	deleterious	-3.75	deleterious	-2.64	medium_impact	3.08	0.5	damaging	0.2	damaging	4.06	23.70	deleterious	0.21	0.55	0.6	disease	0.85	disease	0.47	neutral	0.51	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.83	deleterious	-2.35	low_impact	-0.47	medium_impact	1.75	medium_impact	0.79	0.9	4.29	6.68	0.53	P	0.56	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6841	6841	C	A	MI.3886	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	938	313	A	D	gCt/gAt	4.52	1	0	probably_damaging	1	deleterious	0	neutral	2.4	deleterious	-4.92	deleterious	-3.96	high_impact	5.24	0.67	neutral	0.14	damaging	4.53	24.30	deleterious	0.11	0.55	0.79	disease	0.94	disease	0.77	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.62	0.9	4.29	6.68	0.72	P	0.89	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6841	6841	C	T	MI.3887	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	938	313	A	V	gCt/gTt	4.52	1	0	probably_damaging	0.99	deleterious	0	neutral	2.55	neutral	-2.38	deleterious	-2.64	high_impact	4.68	0.58	damaging	0.13	damaging	4.49	24.30	deleterious	0.32	0.55	0.79	disease	0.91	disease	0.66	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-2.64	low_impact	-1.48	low_impact	3.22	high_impact	0.75	0.9	4.29	6.68	0.61	P	0.75	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6843	6843	A	T	MI.3888	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	940	314	I	F	Atc/Ttc	-9.13	0	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-4.52	deleterious	-2.63	high_impact	4.12	0.53	damaging	0.07	damaging	3.98	23.60	deleterious	0.31	0.55	0.77	disease	0.84	disease	0.68	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.87	0.9	2.34	6.75	0.29	N	0.85	polymorphism	0.63	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6843	6843	A	G	MI.3889	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	940	314	I	V	Atc/Gtc	-9.13	0	0	probably_damaging	0.92	neutral	1	neutral	3.15	neutral	0.49	neutral	0.23	neutral_impact	-0.79	0.52	damaging	0.23	damaging	0.41	6.69	deleterious	0.5	0.6	0.19	neutral	0.06	neutral	0.34	neutral	0.19	neutral	6	0.92	neutral	0.54	deleterious	-2	neutral	0.52	deleterious	-1.76	low_impact	1.86	high_impact	-1.83	low_impact	0.77	0.9	2.34	6.75	0.33	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8708	8708	A	G	MI.389	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	182	61	H	R	cAc/cGc	-0.33	0	0	probably_damaging	0.99	neutral	0.09	neutral	4.39	neutral	-0.29	deleterious	-4.09	low_impact	1.59	0.85	neutral	0.1	damaging	2.76	21.20	deleterious	0.63	0.7	0.53	disease	0.54	disease	0.73	disease	0.75	disease	5	1	deleterious	0.05	neutral	-2	neutral	0.78	deleterious	-2.65	low_impact	-0.28	medium_impact	0.27	medium_impact	0.34	0.9	48.67	8.33	0.29	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6843	6843	A	C	MI.3890	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	940	314	I	L	Atc/Ctc	-9.13	0	0	probably_damaging	0.97	deleterious	0	neutral	2.79	neutral	-1.02	neutral	-1.31	medium_impact	2.43	0.51	damaging	0.08	damaging	3.90	23.50	deleterious	0.35	0.55	0.33	neutral	0.63	disease	0.55	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.61	deleterious	-2.18	low_impact	-1.48	low_impact	1.15	medium_impact	0.83	0.9	2.34	6.75	0.32	N	0.61	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6844	6844	T	C	MI.3891	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	941	314	I	T	aTc/aCc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.84	neutral	-2.4	high_impact	4.12	0.48	damaging	0.09	damaging	3.48	23.10	deleterious	0.43	0.55	0.74	disease	0.64	disease	0.65	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.68	0.9	2.34	6.75	0.5	P	0.76	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6844	6844	T	A	MI.3892	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	941	314	I	N	aTc/aAc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-6.6	deleterious	-4.16	high_impact	4.12	0.48	damaging	0.09	damaging	4.49	24.30	deleterious	0.3	0.55	0.92	disease	0.88	disease	0.68	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.75	0.9	2.34	6.75	0.48	N	0.94	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6844	6844	T	G	MI.3893	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	941	314	I	S	aTc/aGc	7.07	1	0	probably_damaging	1	deleterious	0.02	neutral	2.57	deleterious	-4.29	deleterious	-3.5	high_impact	4.12	0.47	damaging	0.13	damaging	4.34	24.00	deleterious	0.27	0.55	0.85	disease	0.84	disease	0.65	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-0.75	medium_impact	2.71	high_impact	0.65	0.9	2.34	6.75	0.53	P	0.62	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6845	6845	C	G	MI.3894	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	942	314	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.26	neutral	-1.53	high_impact	3.56	0.54	damaging	0.08	damaging	3.50	23.10	deleterious	0.41	0.55	0.52	disease	0.62	disease	0.67	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.19	high_impact	0.93	0.95	2.34	6.75	0.46	N	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6845	6845	C	A	MI.3895	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	942	314	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.26	neutral	-1.53	high_impact	3.56	0.54	damaging	0.08	damaging	3.94	23.50	deleterious	0.41	0.55	0.52	disease	0.62	disease	0.67	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.19	high_impact	0.93	0.95	2.34	6.75	0.46	N	0.76	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6846	6846	C	A	MI.3896	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	943	315	P	T	Ccc/Acc	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	0.47	deleterious	-8.06	deleterious	-5.24	high_impact	4.94	0.72	neutral	0.05	damaging	3.77	23.40	deleterious	0.29	0.55	0.96	disease	0.83	disease	0.73	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.46	high_impact	0.66	0.9	2.34	6.64	0.59	P	0.80	disease_causing	0.66	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6846	6846	C	T	MI.3897	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	943	315	P	S	Ccc/Tcc	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	0.47	deleterious	-8.3	deleterious	-5.24	high_impact	4.94	0.73	neutral	0.05	damaging	3.98	23.60	deleterious	0.37	0.55	0.95	disease	0.87	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.46	high_impact	0.31	0.9	2.34	6.64	0.61	P	0.85	disease_causing	0.67	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6846	6846	C	G	MI.3898	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	943	315	P	A	Ccc/Gcc	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	0.48	deleterious	-7.43	deleterious	-5.24	high_impact	5.29	0.71	neutral	0.07	damaging	3.19	22.70	deleterious	0.26	0.55	0.94	disease	0.72	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.68	0.9	2.34	6.64	0.59	P	0.76	disease_causing	0.55	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6847	6847	C	T	MI.3899	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	944	315	P	L	cCc/cTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	0.46	deleterious	-8.94	deleterious	-6.55	high_impact	4.94	0.71	neutral	0.03	damaging	4.50	24.30	deleterious	0.31	0.55	0.97	disease	0.89	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.46	high_impact	0.70	0.9	2.34	6.64	0.62	P	0.87	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8543	8543	T	A	MI.39	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	17	6	F	Y	tTc/tAc	4.76	1	0	probably_damaging	0.92	deleterious	0	neutral	4.01	neutral	-1.33	deleterious	-2.52	medium_impact	3.32	0.58	damaging	0.54	neutral	4.13	23.80	deleterious	0.41	0.65	0.35	neutral	0.62	disease	0.78	disease	0.74	disease	5	1	deleterious	0.04	neutral	5	deleterious	0.72	deleterious	-1.76	low_impact	-1.4	low_impact	1.75	medium_impact	0.48	0.9	39.82	8.43	0.62	P	0.89	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8708	8708	A	C	MI.390	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	182	61	H	P	cAc/cCc	-0.33	0	0	probably_damaging	0.99	neutral	0.07	neutral	4.38	neutral	-0.9	deleterious	-5.46	low_impact	1.25	0.78	neutral	0.08	damaging	3.07	22.40	deleterious	0.35	0.65	0.43	neutral	0.8	disease	0.79	disease	0.77	disease	5	1	deleterious	0.04	neutral	-2	neutral	0.80	deleterious	-2.65	low_impact	-0.34	medium_impact	-0.03	medium_impact	0.33	0.9	48.67	8.33	0.25	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6847	6847	C	A	MI.3900	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	944	315	P	H	cCc/cAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	0.45	deleterious	-10.45	deleterious	-5.9	high_impact	4.74	0.72	neutral	0.04	damaging	4.12	23.80	deleterious	0.24	0.55	0.98	disease	0.88	disease	0.82	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.28	high_impact	0.66	0.9	2.34	6.64	0.6	P	0.81	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6847	6847	C	G	MI.3901	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	944	315	P	R	cCc/cGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	0.45	deleterious	-9.57	deleterious	-5.9	high_impact	5.29	0.72	neutral	0.04	damaging	3.68	23.30	deleterious	0.21	0.55	0.97	disease	0.92	disease	0.83	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.59	0.9	2.34	6.64	0.62	P	0.90	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6849	6849	A	C	MI.3902	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	946	316	T	P	Acc/Ccc	-10.75	0	0	probably_damaging	0.91	deleterious	0	neutral	2.63	deleterious	-4.1	deleterious	-3.93	high_impact	4.72	0.52	damaging	0.17	damaging	4.11	23.70	deleterious	0.17	0.55	0.88	disease	0.86	disease	0.69	disease	0.75	disease	5	1	deleterious	0.05	neutral	6	deleterious	0.83	deleterious	-1.7	low_impact	-1.48	low_impact	3.26	high_impact	0.42	0.9	2.34	7.13	0.62	P	0.92	disease_causing	0.77	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6849	6849	A	G	MI.3903	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	946	316	T	A	Acc/Gcc	-10.75	0	0	benign	0.18	deleterious	0	neutral	2.68	neutral	-2.64	deleterious	-3.27	high_impact	5.28	0.8	neutral	0.14	damaging	4.11	23.80	deleterious	0.35	0.55	0.53	disease	0.7	disease	0.69	disease	0.67	disease	3	1	deleterious	0.41	neutral	2	deleterious	0.36	neutral	-0.14	medium_impact	-1.48	low_impact	3.78	high_impact	0.45	0.9	2.34	7.13	0.57	N	0.69	polymorphism	0.6	0.27	.	.	.	.	.	lymphoblast cell line	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6849	6849	A	T	MI.3904	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	946	316	T	S	Acc/Tcc	-10.75	0	0	benign	0.37	deleterious	0.04	neutral	2.85	neutral	-0.76	deleterious	-2.62	high_impact	3.89	0.76	neutral	0.16	damaging	3.96	23.60	deleterious	0.3	0.55	0.44	neutral	0.8	disease	0.65	disease	0.67	disease	3	0.95	neutral	0.34	neutral	2	deleterious	0.47	deleterious	-0.54	medium_impact	-0.58	medium_impact	2.49	high_impact	0.54	0.9	2.34	7.13	0.35	N	0.79	polymorphism	0.82	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6850	6850	C	G	MI.3905	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	947	316	T	S	aCc/aGc	8.69	1	0	benign	0.37	deleterious	0.04	neutral	2.85	neutral	-0.76	deleterious	-2.62	high_impact	3.89	0.76	neutral	0.16	damaging	3.60	23.20	deleterious	0.3	0.55	0.44	neutral	0.8	disease	0.65	disease	0.67	disease	3	0.95	neutral	0.34	neutral	2	deleterious	0.47	deleterious	-0.54	medium_impact	-0.58	medium_impact	2.49	high_impact	0.54	0.9	2.34	7.13	0.53	P	0.79	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6850	6850	C	T	MI.3906	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	947	316	T	I	aCc/aTc	8.69	1	0	benign	0.04	deleterious	0	neutral	2.68	neutral	-2.59	deleterious	-3.93	high_impact	5.28	0.59	damaging	0.15	damaging	4.06	23.70	deleterious	0.29	0.55	0.91	disease	0.91	disease	0.65	disease	0.77	disease	5	1	deleterious	0.48	deleterious	2	deleterious	0.35	neutral	0.54	medium_impact	-1.48	low_impact	3.78	high_impact	0.50	0.9	2.34	7.13	0.66	P	0.92	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6850	6850	C	A	MI.3907	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	947	316	T	N	aCc/aAc	8.69	1	0	possibly_damaging	0.87	deleterious	0	neutral	2.63	deleterious	-4.2	deleterious	-3.27	high_impact	4.93	0.64	neutral	0.11	damaging	3.74	23.30	deleterious	0.35	0.55	0.87	disease	0.86	disease	0.72	disease	0.75	disease	5	1	deleterious	0.07	neutral	5	deleterious	0.81	deleterious	-1.53	low_impact	-1.48	low_impact	3.45	high_impact	0.75	0.9	2.34	7.13	0.73	P	0.80	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6852	6852	G	C	MI.3908	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	949	317	G	R	Ggc/Cgc	-13.06	0	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.37	deleterious	-5.25	high_impact	5.26	0.48	damaging	0.15	damaging	4.04	23.70	deleterious	0.17	0.55	0.73	disease	0.9	disease	0.8	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.78	0.9	1.95	6.99	0.65	P	0.95	polymorphism	0.65	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6852	6852	G	T	MI.3909	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	949	317	G	C	Ggc/Tgc	-13.06	0	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.84	deleterious	-5.9	high_impact	4.58	0.44	damaging	0.15	damaging	4.23	23.90	deleterious	0.15	0.55	0.81	disease	0.89	disease	0.71	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.55	0.9	1.95	6.99	0.46	N	0.98	disease_causing	0.52	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8709	8709	C	G	MI.391	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	183	61	H	Q	caC/caG	6.14	0.87	0	probably_damaging	0.99	neutral	0.06	neutral	4.38	neutral	-0.44	deleterious	-4.06	low_impact	1.04	0.88	neutral	0.26	damaging	3.39	23.00	deleterious	0.62	0.7	0.56	disease	0.41	neutral	0.69	disease	0.65	disease	3	1	deleterious	0.04	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	-0.38	medium_impact	-0.21	medium_impact	0.44	0.9	48.67	8.33	0.47	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6852	6852	G	A	MI.3910	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	949	317	G	S	Ggc/Agc	-13.06	0	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-2.97	deleterious	-3.93	high_impact	4.12	0.44	damaging	0.24	damaging	4.25	23.90	deleterious	0.2	0.55	0.59	disease	0.84	disease	0.63	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.56	0.9	1.95	6.99	0.42	N	0.73	polymorphism	0.79	0.28	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6853	6853	G	C	MI.3911	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	950	317	G	A	gGc/gCc	7.53	1	0	probably_damaging	1	deleterious	0.04	neutral	2.75	neutral	-1.92	deleterious	-3.93	high_impact	3.82	0.51	damaging	0.33	neutral	3.24	22.80	deleterious	0.23	0.55	0.41	neutral	0.69	disease	0.66	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-0.58	medium_impact	2.43	high_impact	0.68	0.9	1.95	6.99	0.52	P	0.64	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6853	6853	G	T	MI.3912	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	950	317	G	V	gGc/gTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-1.31	deleterious	-5.9	high_impact	5.26	0.47	damaging	0.19	damaging	3.88	23.50	deleterious	0.15	0.55	0.47	neutral	0.89	disease	0.7	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.54	0.9	1.95	6.99	0.71	P	0.93	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6853	6853	G	A	MI.3913	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	950	317	G	D	gGc/gAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-4.14	deleterious	-4.59	high_impact	4.92	0.43	damaging	0.17	damaging	3.89	23.50	deleterious	0.16	0.55	0.8	disease	0.88	disease	0.79	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.35	0.9	1.95	6.99	0.82	P	0.97	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6855	6855	G	A	MI.3914	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	952	318	V	I	Gtc/Atc	-11.67	0	0	probably_damaging	0.97	neutral	1	neutral	2.8	neutral	-0.43	neutral	0.57	neutral_impact	-1.62	0.64	neutral	0.29	neutral	-0.95	0.02	neutral	0.47	0.55	0.16	neutral	0.07	neutral	0.18	neutral	0.25	neutral	5	0.97	neutral	0.52	deleterious	-2	neutral	0.58	deleterious	-2.18	low_impact	1.86	high_impact	-2.6	low_impact	0.86	0.9	3.51	7.96	0.35	N	0.24	polymorphism	1	0.01	.	.	.	.	.	pituitary oncocytoma	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6855	6855	G	T	MI.3915	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	952	318	V	F	Gtc/Ttc	-11.67	0	0	probably_damaging	1	deleterious	0	neutral	2.62	neutral	-2.74	neutral	-2.05	medium_impact	2.77	0.61	neutral	0.12	damaging	3.87	23.50	deleterious	0.15	0.55	0.64	disease	0.9	disease	0.57	disease	0.76	disease	5	1	deleterious	0	deleterious	5	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	1.46	medium_impact	0.79	0.9	3.51	7.96	0.25	N	0.86	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6855	6855	G	C	MI.3916	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	952	318	V	L	Gtc/Ctc	-11.67	0	0	probably_damaging	0.97	deleterious	0	neutral	2.86	neutral	-0.6	neutral	-0.74	medium_impact	2.77	0.68	neutral	0.13	damaging	1.77	14.81	neutral	0.38	0.55	0.41	neutral	0.7	disease	0.42	neutral	0.49	neutral	0	1	deleterious	0.02	neutral	5	deleterious	0.76	deleterious	-2.18	low_impact	-1.48	low_impact	1.46	medium_impact	0.79	0.9	3.51	7.96	0.35	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6856	6856	T	G	MI.3917	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	953	318	V	G	gTc/gGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-4.26	deleterious	-4.59	medium_impact	3.46	0.64	neutral	0.17	damaging	3.89	23.50	deleterious	0.13	0.55	0.76	disease	0.81	disease	0.56	disease	0.72	disease	4	1	deleterious	0	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.1	high_impact	0.64	0.9	3.51	7.96	0.46	N	0.71	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6856	6856	T	C	MI.3918	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	953	318	V	A	gTc/gCc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.74	neutral	-1.99	deleterious	-2.62	medium_impact	3.46	0.64	neutral	0.16	damaging	3.40	23.00	deleterious	0.31	0.55	0.28	neutral	0.57	disease	0.55	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	2.1	high_impact	0.64	0.9	3.51	7.96	0.5	P	0.47	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6856	6856	T	A	MI.3919	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	953	318	V	D	gTc/gAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-5.38	deleterious	-3.97	medium_impact	3.46	0.61	neutral	0.14	damaging	4.51	24.30	deleterious	0.08	0.55	0.85	disease	0.9	disease	0.68	disease	0.73	disease	5	1	deleterious	0	neutral	5	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.1	high_impact	0.76	0.9	3.51	7.96	0.46	N	0.83	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8709	8709	C	A	MI.392	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	183	61	H	Q	caC/caA	6.14	0.87	0	probably_damaging	0.99	neutral	0.06	neutral	4.38	neutral	-0.44	deleterious	-4.06	low_impact	1.04	0.88	neutral	0.26	damaging	3.77	23.40	deleterious	0.62	0.7	0.56	disease	0.41	neutral	0.69	disease	0.65	disease	3	1	deleterious	0.04	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	-0.38	medium_impact	-0.21	medium_impact	0.44	0.9	48.67	8.33	0.47	N	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6858	6858	A	G	MI.3920	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	955	319	K	E	Aaa/Gaa	-9.13	0	0	benign	0.33	deleterious	0	neutral	2.68	neutral	-2.21	deleterious	-2.56	high_impact	5.28	0.51	damaging	0.51	neutral	4.11	23.70	deleterious	0.31	0.55	0.66	disease	0.9	disease	0.71	disease	0.73	disease	5	1	deleterious	0.34	neutral	2	deleterious	0.84	deleterious	-0.47	medium_impact	-1.48	low_impact	3.78	high_impact	0.66	0.9	2.34	6.86	0.66	P	0.75	polymorphism	0.98	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6858	6858	A	C	MI.3921	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	955	319	K	Q	Aaa/Caa	-9.13	0	0	benign	0.39	deleterious	0	neutral	2.69	neutral	-2.33	deleterious	-2.56	high_impact	4.72	0.65	neutral	0.55	neutral	3.54	23.10	deleterious	0.39	0.55	0.55	disease	0.84	disease	0.68	disease	0.71	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.79	deleterious	-0.57	medium_impact	-1.48	low_impact	3.26	high_impact	0.73	0.9	2.34	6.86	0.64	P	0.64	polymorphism	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6859	6859	A	C	MI.3922	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	956	319	K	T	aAa/aCa	8.69	1	0	benign	0.03	deleterious	0	neutral	2.82	neutral	-1.23	deleterious	-3.83	high_impact	5.28	0.61	neutral	0.52	neutral	3.79	23.40	deleterious	0.24	0.55	0.34	neutral	0.85	disease	0.66	disease	0.71	disease	4	1	deleterious	0.49	deleterious	2	deleterious	0.37	neutral	0.66	medium_impact	-1.48	low_impact	3.78	high_impact	0.55	0.9	2.34	6.86	0.65	P	0.76	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6859	6859	A	T	MI.3923	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	956	319	K	M	aAa/aTa	8.69	1	0	possibly_damaging	0.89	deleterious	0	neutral	2.72	deleterious	-4.18	deleterious	-3.86	high_impact	4.72	0.67	neutral	0.58	neutral	4.07	23.70	deleterious	0.19	0.55	0.89	disease	0.86	disease	0.69	disease	0.72	disease	4	1	deleterious	0.06	neutral	5	deleterious	0.85	deleterious	-1.61	low_impact	-1.48	low_impact	3.26	high_impact	0.55	0.9	2.34	6.86	0.72	P	0.89	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6860	6860	A	C	MI.3924	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	957	319	K	N	aaA/aaC	8.69	1	0	possibly_damaging	0.54	deleterious	0	neutral	2.67	deleterious	-3.15	deleterious	-3.19	high_impact	4.93	0.57	damaging	0.46	neutral	3.83	23.40	deleterious	0.44	0.55	0.74	disease	0.84	disease	0.64	disease	0.69	disease	4	1	deleterious	0.23	neutral	5	deleterious	0.85	deleterious	-0.82	medium_impact	-1.48	low_impact	3.45	high_impact	0.70	0.9	2.34	6.86	0.68	P	0.76	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6860	6860	A	T	MI.3925	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	957	319	K	N	aaA/aaT	8.69	1	0	possibly_damaging	0.54	deleterious	0	neutral	2.67	deleterious	-3.15	deleterious	-3.19	high_impact	4.93	0.57	damaging	0.46	neutral	4.02	23.60	deleterious	0.44	0.55	0.74	disease	0.84	disease	0.64	disease	0.69	disease	4	1	deleterious	0.23	neutral	5	deleterious	0.85	deleterious	-0.82	medium_impact	-1.48	low_impact	3.45	high_impact	0.70	0.9	2.34	6.86	0.69	P	0.76	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6861	6861	G	T	MI.3926	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	958	320	V	L	Gta/Tta	4.76	1	0	probably_damaging	0.99	deleterious	0	neutral	2.57	neutral	-1.43	neutral	-1.24	medium_impact	3.29	0.57	damaging	0.11	damaging	1.89	15.52	deleterious	0.43	0.55	0.42	neutral	0.79	disease	0.5	neutral	0.62	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	1.94	medium_impact	0.80	0.9	3.51	7.73	0.46	N	0.55	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6861	6861	G	C	MI.3927	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	958	320	V	L	Gta/Cta	4.76	1	0	probably_damaging	0.99	deleterious	0	neutral	2.57	neutral	-1.43	neutral	-1.24	medium_impact	3.29	0.57	damaging	0.11	damaging	1.77	14.80	neutral	0.43	0.55	0.42	neutral	0.79	disease	0.5	neutral	0.62	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	1.94	medium_impact	0.80	0.9	3.51	7.73	0.43	N	0.55	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6861	6861	G	A	MI.3928	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	958	320	V	M	Gta/Ata	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.53	neutral	-1.78	neutral	-1.6	medium_impact	3.29	0.6	damaging	0.15	damaging	3.81	23.40	deleterious	0.41	0.55	0.69	disease	0.74	disease	0.51	disease	0.47	neutral	1	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	1.94	medium_impact	0.80	0.9	3.51	7.73	0.43	N	0.82	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6862	6862	T	C	MI.3929	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	959	320	V	A	gTa/gCa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-1.77	deleterious	-2.6	high_impact	4.26	0.59	damaging	0.16	damaging	3.62	23.20	deleterious	0.34	0.55	0.45	neutral	0.68	disease	0.58	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.68	0.9	3.51	7.73	0.51	P	0.47	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8710	8710	A	C	MI.393	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	184	62	N	H	Aac/Cac	-4.5	0	0	possibly_damaging	0.8	neutral	0.1	neutral	4.38	neutral	-0.25	deleterious	-4.11	medium_impact	2.81	0.82	neutral	0.62	neutral	2.73	21.00	deleterious	0.86	0.9	0.56	disease	0.73	disease	0.35	neutral	0.5	disease	0	0.94	neutral	0.15	neutral	0	NA	0.67	deleterious	-1.33	low_impact	-0.25	medium_impact	1.31	medium_impact	0.64	0.9	18.14	14.91	0.35	N	0.50	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6862	6862	T	A	MI.3930	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	959	320	V	E	gTa/gAa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.65	deleterious	-3.92	high_impact	4.26	0.59	damaging	0.16	damaging	4.90	24.90	deleterious	0.09	0.55	0.83	disease	0.93	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.50	0.9	3.51	7.73	0.5	N	0.84	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6862	6862	T	G	MI.3931	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	959	320	V	G	gTa/gGa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.78	deleterious	-4.57	high_impact	3.91	0.6	damaging	0.15	damaging	3.90	23.50	deleterious	0.13	0.55	0.82	disease	0.85	disease	0.63	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.51	high_impact	0.70	0.9	3.51	7.73	0.46	N	0.71	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6864	6864	T	G	MI.3932	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	961	321	F	V	Ttt/Gtt	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	2.55	neutral	-2.8	deleterious	-4.58	high_impact	4.22	0.72	neutral	0.06	damaging	4.04	23.70	deleterious	0.17	0.55	0.53	disease	0.87	disease	0.66	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.8	high_impact	0.66	0.9	3.31	6.68	0.34	N	0.84	polymorphism	0.78	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6864	6864	T	A	MI.3933	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	961	321	F	I	Ttt/Att	-6.12	0	0	probably_damaging	0.99	deleterious	0	neutral	2.51	deleterious	-3	deleterious	-3.92	high_impact	4.92	0.74	neutral	0.07	damaging	4.42	24.20	deleterious	0.16	0.55	0.68	disease	0.83	disease	0.64	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.64	low_impact	-1.48	low_impact	3.44	high_impact	0.64	0.9	3.31	6.68	0.62	P	0.88	polymorphism	0.88	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6864	6864	T	C	MI.3934	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	961	321	F	L	Ttt/Ctt	-6.12	0	0	probably_damaging	0.98	deleterious	0	neutral	2.53	neutral	-2.13	deleterious	-3.92	high_impact	4.03	0.74	neutral	0.05	damaging	4.07	23.70	deleterious	0.31	0.55	0.6	disease	0.79	disease	0.63	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	2.62	high_impact	0.72	0.9	3.31	6.68	0.28	N	0.83	polymorphism	0.87	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6865	6865	T	A	MI.3935	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	962	321	F	Y	tTt/tAt	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.39	deleterious	-3.49	neutral	-1.96	high_impact	4.23	0.74	neutral	0.06	damaging	4.42	24.20	deleterious	0.18	0.55	0.7	disease	0.8	disease	0.61	disease	0.59	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.35	low_impact	-1.48	low_impact	2.81	high_impact	0.68	0.9	3.31	6.68	0.55	P	0.59	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6865	6865	T	G	MI.3936	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	962	321	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.37	deleterious	-5.59	deleterious	-5.23	high_impact	5.27	0.72	neutral	0.05	damaging	4.18	23.80	deleterious	0.14	0.55	0.91	disease	0.86	disease	0.68	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.77	high_impact	0.44	0.9	3.31	6.68	0.68	P	0.91	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6865	6865	T	C	MI.3937	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	962	321	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.38	deleterious	-4.19	deleterious	-5.23	high_impact	4.58	0.74	neutral	0.08	damaging	4.39	24.10	deleterious	0.13	0.55	0.77	disease	0.86	disease	0.64	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.60	0.9	3.31	6.68	0.53	P	0.84	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6866	6866	T	A	MI.3938	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	963	321	F	L	ttT/ttA	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.53	neutral	-2.13	deleterious	-3.92	high_impact	4.03	0.74	neutral	0.05	damaging	4.55	24.40	deleterious	0.31	0.55	0.6	disease	0.79	disease	0.63	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	2.62	high_impact	0.72	0.9	3.31	6.68	0.57	P	0.83	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6866	6866	T	G	MI.3939	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	963	321	F	L	ttT/ttG	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.53	neutral	-2.13	deleterious	-3.92	high_impact	4.03	0.74	neutral	0.05	damaging	4.51	24.30	deleterious	0.31	0.55	0.6	disease	0.79	disease	0.63	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	2.62	high_impact	0.72	0.9	3.31	6.68	0.56	P	0.83	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8710	8710	A	G	MI.394	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	184	62	N	D	Aac/Gac	-4.5	0	0	benign	0.19	neutral	0.18	neutral	4.41	neutral	0.28	deleterious	-3.9	medium_impact	2.46	0.75	neutral	0.58	neutral	1.85	15.28	deleterious	0.9	0.95	0.45	neutral	0.73	disease	0.54	disease	0.57	disease	1	0.79	neutral	0.5	deleterious	-3	neutral	0.34	neutral	-0.16	medium_impact	-0.08	medium_impact	1.01	medium_impact	0.74	0.9	18.14	14.91	0.38	N	0.55	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6867	6867	A	G	MI.3940	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	964	322	S	G	Agc/Ggc	-3.11	0	0	probably_damaging	0.99	neutral	0.05	neutral	2.81	neutral	-1.49	deleterious	-2.59	high_impact	4.49	0.43	damaging	0.09	damaging	3.65	23.20	deleterious	0.28	0.55	0.59	disease	0.69	disease	0.57	disease	0.64	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.77	deleterious	-2.64	low_impact	-0.52	medium_impact	3.05	high_impact	0.72	0.9	1.75	6.66	0.45	N	0.70	polymorphism	0.75	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6867	6867	A	C	MI.3941	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	964	322	S	R	Agc/Cgc	-3.11	0	0	probably_damaging	1	deleterious	0.02	neutral	2.78	neutral	-1.86	deleterious	-3.26	high_impact	5.18	0.54	damaging	0.02	damaging	3.90	23.50	deleterious	0.15	0.55	0.61	disease	0.87	disease	0.74	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-0.75	medium_impact	3.68	high_impact	0.77	0.9	1.75	6.66	0.66	P	0.98	disease_causing	0.63	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6867	6867	A	T	MI.3942	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	964	322	S	C	Agc/Tgc	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.81	deleterious	-3.26	high_impact	5.18	0.51	damaging	0.02	damaging	3.49	23.10	deleterious	0.2	0.55	0.53	disease	0.83	disease	0.62	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.65	0.9	1.75	6.66	0.6	P	0.85	disease_causing	0.58	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6868	6868	G	T	MI.3943	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	965	322	S	I	aGc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-2.07	deleterious	-3.91	high_impact	5.18	0.55	damaging	0.04	damaging	4.20	23.90	deleterious	0.17	0.55	0.72	disease	0.9	disease	0.64	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.75	0.9	1.75	6.66	0.72	P	0.96	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6868	6868	G	C	MI.3944	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	965	322	S	T	aGc/aCc	8.69	1	0	probably_damaging	0.97	deleterious	0	neutral	2.83	neutral	-0.64	neutral	-1.96	high_impact	4.21	0.53	damaging	0.04	damaging	3.44	23.00	deleterious	0.25	0.55	0.35	neutral	0.73	disease	0.62	disease	0.65	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.18	low_impact	-1.48	low_impact	2.79	high_impact	0.78	0.9	1.75	6.66	0.5	P	0.43	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6868	6868	G	A	MI.3945	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	965	322	S	N	aGc/aAc	8.69	1	0	probably_damaging	0.97	neutral	0.06	neutral	3.09	neutral	0.95	neutral	-1.95	medium_impact	2.51	0.47	damaging	0.04	damaging	3.65	23.20	deleterious	0.48	0.55	0.17	neutral	0.79	disease	0.55	disease	0.56	disease	1	0.99	deleterious	0.05	neutral	1	deleterious	0.72	deleterious	-2.18	low_impact	-0.47	medium_impact	1.22	medium_impact	0.58	0.9	1.75	6.66	0.55	P	0.66	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6870	6870	T	C	MI.3946	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	967	323	W	R	Tga/Cga	0.13	0.98	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-3.8	deleterious	-9.15	high_impact	4.74	0.62	neutral	0.04	damaging	3.66	23.20	deleterious	0.19	0.55	0.93	disease	0.93	disease	0.79	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.28	high_impact	0.28	0.9	1.36	6.89	0.6	P	0.98	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6870	6870	T	G	MI.3947	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	967	323	W	G	Tga/Gga	0.13	0.98	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.03	deleterious	-8.49	high_impact	5.29	0.66	neutral	0.05	damaging	3.99	23.60	deleterious	0.15	0.55	0.94	disease	0.88	disease	0.77	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.23	0.9	1.36	6.89	0.6	P	0.89	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6871	6871	G	T	MI.3948	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	968	323	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-1.21	deleterious	-8.49	high_impact	4.93	0.69	neutral	0.04	damaging	4.32	24.00	deleterious	0.15	0.55	0.61	disease	0.87	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.20	0.9	1.36	6.89	0.7	P	0.95	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6871	6871	G	C	MI.3949	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	968	323	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.08	deleterious	-9.14	high_impact	4.93	0.65	neutral	0.06	damaging	4.11	23.70	deleterious	0.15	0.55	0.9	disease	0.93	disease	0.76	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.22	0.9	1.36	6.89	0.63	P	0.89	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8710	8710	A	T	MI.395	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	184	62	N	Y	Aac/Tac	-4.5	0	0	possibly_damaging	0.8	neutral	0.15	neutral	4.3	neutral	-2.6	deleterious	-6.55	medium_impact	3.06	0.8	neutral	0.42	neutral	3.29	22.80	deleterious	0.57	0.65	0.56	disease	0.83	disease	0.45	neutral	0.71	disease	4	0.91	neutral	0.18	neutral	0	NA	0.72	deleterious	-1.33	low_impact	-0.13	medium_impact	1.53	medium_impact	0.62	0.9	18.14	14.91	0.33	N	0.89	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6872	6872	A	T	MI.3950	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	969	323	W	C	tgA/tgT	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.66	deleterious	-8.49	high_impact	5.29	0.59	damaging	0.05	damaging	4.21	23.90	deleterious	0.19	0.55	0.96	disease	0.93	disease	0.81	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.27	0.9	1.36	6.89	0.61	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6872	6872	A	C	MI.3951	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	969	323	W	C	tgA/tgC	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.66	deleterious	-8.49	high_impact	5.29	0.59	damaging	0.05	damaging	4.09	23.70	deleterious	0.19	0.55	0.96	disease	0.93	disease	0.81	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.79	high_impact	0.27	0.9	1.36	6.89	0.61	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6873	6873	C	G	MI.3952	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	970	324	L	V	Ctc/Gtc	0.59	0.11	0	probably_damaging	0.99	deleterious	0.02	neutral	2.64	neutral	-0.99	neutral	-1.37	medium_impact	2.42	0.56	damaging	0.07	damaging	3.51	23.10	deleterious	0.33	0.55	0.31	neutral	0.63	disease	0.32	neutral	0.21	neutral	6	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-2.64	low_impact	-0.75	medium_impact	1.14	medium_impact	0.76	0.9	2.14	6.81	0.33	N	0.66	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6873	6873	C	A	MI.3953	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	970	324	L	I	Ctc/Atc	0.59	0.11	0	probably_damaging	1	neutral	0.12	neutral	2.72	neutral	-0.4	neutral	-0.91	low_impact	1.46	0.57	damaging	0.09	damaging	4.08	23.70	deleterious	0.27	0.55	0.26	neutral	0.4	neutral	0.25	neutral	0.43	neutral	1	1	deleterious	0.06	neutral	-2	neutral	0.72	deleterious	-3.58	low_impact	-0.29	medium_impact	0.25	medium_impact	0.86	0.9	2.14	6.81	0.37	N	0.54	disease_causing	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6873	6873	C	T	MI.3954	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	970	324	L	F	Ctc/Ttc	0.59	0.11	0	probably_damaging	1	deleterious	0	neutral	2.62	neutral	-2.31	neutral	-2.15	high_impact	3.92	0.52	damaging	0.05	damaging	4.10	23.70	deleterious	0.35	0.55	0.68	disease	0.74	disease	0.45	neutral	0.41	neutral	2	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.52	high_impact	0.83	0.9	2.14	6.81	0.34	N	0.87	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6874	6874	T	A	MI.3955	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	971	324	L	H	cTc/cAc	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-4.7	deleterious	-3.9	high_impact	4.47	0.56	damaging	0.04	damaging	4.33	24.00	deleterious	0.11	0.55	0.88	disease	0.84	disease	0.62	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.03	high_impact	0.64	0.9	2.14	6.81	0.35	N	0.83	disease_causing	0.98	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6874	6874	T	C	MI.3956	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	971	324	L	P	cTc/cCc	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.75	deleterious	-3.88	high_impact	4.82	0.47	damaging	0.05	damaging	4.04	23.70	deleterious	0.11	0.55	0.87	disease	0.88	disease	0.66	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.72	0.9	2.14	6.81	0.57	P	0.83	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6874	6874	T	G	MI.3957	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	971	324	L	R	cTc/cGc	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.17	deleterious	-3.3	high_impact	4.82	0.53	damaging	0.04	damaging	4.32	24.00	deleterious	0.1	0.55	0.83	disease	0.9	disease	0.66	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.55	0.9	2.14	6.81	0.63	P	0.90	disease_causing	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6876	6876	G	T	MI.3958	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	973	325	A	S	Gcc/Tcc	-1.95	0	0	probably_damaging	1	neutral	0.08	neutral	2.74	neutral	-2.56	neutral	-1.65	low_impact	1.61	0.63	neutral	0.2	damaging	3.71	23.30	deleterious	0.29	0.55	0.46	neutral	0.76	disease	0.33	neutral	0.23	neutral	5	1	deleterious	0.04	neutral	-2	neutral	0.80	deleterious	-3.58	low_impact	-0.4	medium_impact	0.39	medium_impact	0.81	0.9	3.9	7.44	0.32	N	0.64	disease_causing	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6876	6876	G	C	MI.3959	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	973	325	A	P	Gcc/Ccc	-1.95	0	0	probably_damaging	1	deleterious	0.01	neutral	2.68	deleterious	-4.63	deleterious	-2.98	high_impact	4.88	0.5	damaging	0.15	damaging	3.90	23.50	deleterious	0.09	0.55	0.33	neutral	0.87	disease	0.69	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-0.92	medium_impact	3.41	high_impact	0.78	0.9	3.9	7.44	0.61	P	0.85	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8711	8711	A	T	MI.396	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	185	62	N	I	aAc/aTc	1.29	0	0	possibly_damaging	0.74	neutral	0.14	neutral	4.31	neutral	-2.31	deleterious	-7.31	medium_impact	2.81	0.78	neutral	0.48	neutral	3.59	23.20	deleterious	0.46	0.65	0.73	disease	0.87	disease	0.51	disease	0.64	disease	3	0.9	neutral	0.2	neutral	0	NA	0.67	deleterious	-1.19	low_impact	-0.15	medium_impact	1.31	medium_impact	0.51	0.9	18.14	14.91	0.34	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6876	6876	G	A	MI.3960	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	973	325	A	T	Gcc/Acc	-1.95	0	0	probably_damaging	1	deleterious	0.03	neutral	2.74	neutral	-1.98	neutral	-2.28	medium_impact	2.6	0.46	damaging	0.2	damaging	4.30	24.00	deleterious	0.33	0.55	0.51	disease	0.78	disease	0.47	neutral	0.26	neutral	5	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-3.58	low_impact	-0.65	medium_impact	1.3	medium_impact	0.81	0.9	3.9	7.44	0.37	N	0.20	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6877	6877	C	A	MI.3961	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	974	325	A	D	gCc/gAc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-4.28	deleterious	-3.5	high_impact	4.54	0.56	damaging	0.13	damaging	4.63	24.50	deleterious	0.12	0.55	0.73	disease	0.9	disease	0.67	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.09	high_impact	0.70	0.9	3.9	7.44	0.53	P	0.89	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6877	6877	C	G	MI.3962	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	974	325	A	G	gCc/gGc	9.15	1	0	probably_damaging	1	neutral	0.09	neutral	2.73	neutral	-2.23	neutral	-2.11	low_impact	1.81	0.43	damaging	0.2	damaging	2.99	22.20	deleterious	0.27	0.55	0.38	neutral	0.67	disease	0.35	neutral	0.22	neutral	6	1	deleterious	0.05	neutral	-2	neutral	0.75	deleterious	-3.58	low_impact	-0.37	medium_impact	0.57	medium_impact	0.81	0.9	3.9	7.44	0.66	P	0.56	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6877	6877	C	T	MI.3963	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	974	325	A	V	gCc/gTc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.75	neutral	-2.21	neutral	-2.4	high_impact	4.19	0.51	damaging	0.12	damaging	4.61	24.40	deleterious	0.25	0.55	0.43	neutral	0.81	disease	0.56	disease	0.64	disease	3	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.77	high_impact	0.83	0.9	3.9	7.44	0.55	P	0.75	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6879	6879	A	C	MI.3964	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	976	326	T	P	Aca/Cca	-13.06	0	0	probably_damaging	1	deleterious	0	neutral	2.4	deleterious	-4.88	deleterious	-3.9	high_impact	5.21	0.54	damaging	0.05	damaging	3.61	23.20	deleterious	0.16	0.55	0.85	disease	0.82	disease	0.76	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.71	high_impact	0.68	0.9	1.95	6.61	0.59	P	0.92	polymorphism	0.88	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6879	6879	A	T	MI.3965	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	976	326	T	S	Aca/Tca	-13.06	0	0	probably_damaging	0.98	deleterious	0.01	neutral	2.48	neutral	-2.84	deleterious	-2.59	medium_impact	2.81	0.67	neutral	0.06	damaging	3.52	23.10	deleterious	0.42	0.55	0.52	disease	0.65	disease	0.35	neutral	0.34	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.77	deleterious	-2.35	low_impact	-0.92	medium_impact	1.5	medium_impact	0.76	0.9	1.95	6.61	0.24	N	0.79	polymorphism	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6879	6879	A	G	MI.3966	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	976	326	T	A	Aca/Gca	-13.06	0	0	probably_damaging	0.98	deleterious	0	neutral	2.45	deleterious	-3.46	deleterious	-3.24	high_impact	5.21	0.7	neutral	0.06	damaging	3.60	23.20	deleterious	0.42	0.55	0.6	disease	0.7	disease	0.61	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-1.48	low_impact	3.71	high_impact	0.55	0.9	1.95	6.61	0.58	P	0.69	polymorphism	0.97	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6880	6880	C	A	MI.3967	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	977	326	T	K	aCa/aAa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.41	deleterious	-4.44	deleterious	-3.9	high_impact	5.21	0.62	neutral	0.04	damaging	4.53	24.30	deleterious	0.19	0.55	0.79	disease	0.86	disease	0.74	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.71	high_impact	0.63	0.9	1.95	6.61	0.75	P	0.88	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6880	6880	C	T	MI.3968	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	977	326	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	neutral	0.06	neutral	2.47	neutral	-2.99	deleterious	-3.9	high_impact	3.74	0.67	neutral	0.04	damaging	4.16	23.80	deleterious	0.36	0.55	0.85	disease	0.79	disease	0.66	disease	0.69	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.80	deleterious	-3.58	low_impact	-0.47	medium_impact	2.35	high_impact	0.63	0.9	1.95	6.61	0.52	P	0.96	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6882	6882	C	A	MI.3969	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	979	327	L	I	Ctc/Atc	-9.82	0	0	probably_damaging	0.99	neutral	0.24	neutral	2.7	neutral	-1.57	neutral	-0.62	neutral_impact	0.75	0.59	damaging	0.24	damaging	2.65	20.50	deleterious	0.33	0.55	0.31	neutral	0.36	neutral	0.15	neutral	0.44	neutral	1	0.99	deleterious	0.13	neutral	-2	neutral	0.68	deleterious	-2.64	low_impact	-0.09	medium_impact	-0.41	medium_impact	0.72	0.9	1.95	6.8	0.47	N	0.54	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8711	8711	A	G	MI.397	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	185	62	N	S	aAc/aGc	1.29	0	0	benign	0.02	neutral	0.81	neutral	4.44	neutral	0.51	deleterious	-3.55	neutral_impact	0.71	0.9	neutral	0.94	neutral	-0.24	0.92	neutral	0.85	0.9	0.41	neutral	0.47	neutral	0.26	neutral	0.46	neutral	1	0.14	neutral	0.9	deleterious	-6	neutral	0.18	neutral	0.85	medium_impact	0.65	medium_impact	-0.49	medium_impact	0.40	0.9	18.14	14.91	0.3	N	0.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6882	6882	C	G	MI.3970	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	979	327	L	V	Ctc/Gtc	-9.82	0	0	probably_damaging	0.97	deleterious	0.02	neutral	2.72	neutral	-1.69	neutral	-1.21	medium_impact	2.94	0.56	damaging	0.14	damaging	3.54	23.10	deleterious	0.38	0.55	0.39	neutral	0.57	disease	0.24	neutral	0.37	neutral	3	1	deleterious	0.03	neutral	5	deleterious	0.69	deleterious	-2.18	low_impact	-0.75	medium_impact	1.62	medium_impact	0.65	0.9	1.95	6.8	0.37	N	0.66	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6882	6882	C	T	MI.3971	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	979	327	L	F	Ctc/Ttc	-9.82	0	0	probably_damaging	1	neutral	0.08	neutral	2.6	neutral	-2.64	neutral	-1.89	low_impact	1.84	0.58	damaging	0.17	damaging	4.03	23.60	deleterious	0.36	0.55	0.57	disease	0.63	disease	0.22	neutral	0.26	neutral	5	1	deleterious	0.04	neutral	-2	neutral	0.76	deleterious	-3.58	low_impact	-0.4	medium_impact	0.6	medium_impact	0.70	0.9	1.95	6.8	0.34	N	0.87	polymorphism	0.9	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6883	6883	T	C	MI.3972	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	980	327	L	P	cTc/cCc	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.98	deleterious	-4.01	high_impact	4.5	0.52	damaging	0.1	damaging	4.07	23.70	deleterious	0.13	0.55	0.76	disease	0.89	disease	0.66	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.59	0.9	1.95	6.8	0.38	N	0.83	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6883	6883	T	A	MI.3973	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	980	327	L	H	cTc/cAc	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.94	deleterious	-3.86	high_impact	4.5	0.59	damaging	0.09	damaging	4.42	24.20	deleterious	0.15	0.55	0.75	disease	0.78	disease	0.61	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.49	0.9	1.95	6.8	0.38	N	0.83	disease_causing	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6883	6883	T	G	MI.3974	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	980	327	L	R	cTc/cGc	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.41	deleterious	-3.5	high_impact	4.5	0.57	damaging	0.09	damaging	4.31	24.00	deleterious	0.13	0.55	0.67	disease	0.88	disease	0.65	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.42	0.9	1.95	6.8	0.39	N	0.90	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6885	6885	C	G	MI.3975	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	982	328	H	D	Cac/Gac	-15.6	0	0	probably_damaging	1	deleterious	0.03	neutral	2.79	neutral	-1.2	deleterious	-4.1	high_impact	4.04	0.61	neutral	0.08	damaging	3.98	23.60	deleterious	0.29	0.55	0.65	disease	0.86	disease	0.7	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.65	medium_impact	2.63	high_impact	0.52	0.9	1.75	6.76	0.29	N	0.97	polymorphism	0.89	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6885	6885	C	A	MI.3976	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	982	328	H	N	Cac/Aac	-15.6	0	0	probably_damaging	0.99	deleterious	0.04	neutral	2.83	neutral	-0.86	deleterious	-3.15	low_impact	1.7	0.6	neutral	0.1	damaging	3.98	23.60	deleterious	0.61	0.65	0.52	disease	0.81	disease	0.36	neutral	0.41	neutral	2	1	deleterious	0.03	neutral	2	deleterious	0.80	deleterious	-2.64	low_impact	-0.58	medium_impact	0.47	medium_impact	0.47	0.9	1.75	6.76	0.27	N	0.86	polymorphism	0.97	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6885	6885	C	T	MI.3977	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	982	328	H	Y	Cac/Tac	-15.6	0	0	probably_damaging	0.99	neutral	0.45	neutral	2.89	neutral	0.86	neutral	-1.19	neutral_impact	0.06	0.66	neutral	0.31	neutral	2.39	18.78	deleterious	0.68	0.7	0.17	neutral	0.59	disease	0.21	neutral	0.34	neutral	3	0.99	deleterious	0.23	neutral	-2	neutral	0.73	deleterious	-2.64	low_impact	0.14	medium_impact	-1.04	low_impact	0.29	0.9	1.75	6.76	0.32	N	0.72	polymorphism	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6886	6886	A	C	MI.3978	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	983	328	H	P	cAc/cCc	4.52	1	0	probably_damaging	1	deleterious	0.03	neutral	2.78	neutral	-2	deleterious	-4.54	high_impact	4.04	0.59	damaging	0.09	damaging	3.34	22.90	deleterious	0.28	0.55	0.57	disease	0.93	disease	0.72	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-0.65	medium_impact	2.63	high_impact	0.31	0.9	1.75	6.76	0.44	N	0.90	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6886	6886	A	T	MI.3979	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	983	328	H	L	cAc/cTc	4.52	1	0	probably_damaging	0.99	neutral	0.16	neutral	2.91	neutral	0.19	deleterious	-4.5	low_impact	1.9	0.63	neutral	0.07	damaging	3.94	23.50	deleterious	0.33	0.55	0.27	neutral	0.86	disease	0.43	neutral	0.57	disease	1	0.99	deleterious	0.09	neutral	-2	neutral	0.74	deleterious	-2.64	low_impact	-0.21	medium_impact	0.66	medium_impact	0.32	0.9	1.75	6.76	0.37	N	0.92	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8711	8711	A	C	MI.398	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	185	62	N	T	aAc/aCc	1.29	0	0	benign	0.19	neutral	0.34	neutral	4.35	neutral	-0.68	deleterious	-4.58	medium_impact	2.46	0.89	neutral	0.93	neutral	0.39	6.48	deleterious	0.82	0.85	0.28	neutral	0.71	disease	0.25	neutral	0.47	neutral	1	0.59	neutral	0.58	deleterious	-3	neutral	0.28	neutral	-0.16	medium_impact	0.13	medium_impact	1.01	medium_impact	0.66	0.9	18.14	14.91	0.44	N	0.06	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6886	6886	A	G	MI.3980	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	983	328	H	R	cAc/cGc	4.52	1	0	probably_damaging	0.99	neutral	0.05	neutral	2.87	neutral	-0.2	deleterious	-3.52	high_impact	4.04	0.61	neutral	0.07	damaging	3.10	22.50	deleterious	0.64	0.65	0.48	neutral	0.83	disease	0.51	disease	0.66	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.82	deleterious	-2.64	low_impact	-0.52	medium_impact	2.63	high_impact	0.32	0.9	1.75	6.76	0.46	N	0.85	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6887	6887	C	A	MI.3981	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	984	328	H	Q	caC/caA	8.69	1	0	probably_damaging	0.99	neutral	0.12	neutral	2.83	neutral	-0.7	deleterious	-3.14	low_impact	1.68	0.63	neutral	0.11	damaging	2.84	21.50	deleterious	0.66	0.7	0.5	disease	0.72	disease	0.32	neutral	0.37	neutral	3	1	deleterious	0.07	neutral	-2	neutral	0.79	deleterious	-2.64	low_impact	-0.29	medium_impact	0.45	medium_impact	0.54	0.9	1.75	6.76	0.47	N	0.83	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6887	6887	C	G	MI.3982	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	984	328	H	Q	caC/caG	8.69	1	0	probably_damaging	0.99	neutral	0.12	neutral	2.83	neutral	-0.7	deleterious	-3.14	low_impact	1.68	0.63	neutral	0.11	damaging	2.46	19.19	deleterious	0.66	0.7	0.5	disease	0.72	disease	0.32	neutral	0.37	neutral	3	1	deleterious	0.07	neutral	-2	neutral	0.79	deleterious	-2.64	low_impact	-0.29	medium_impact	0.45	medium_impact	0.54	0.9	1.75	6.76	0.46	N	0.83	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6888	6888	G	T	MI.3983	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	985	329	G	W	Gga/Tga	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-6.38	deleterious	-5.2	high_impact	4.83	0.62	neutral	0.09	damaging	4.53	24.30	deleterious	0.17	0.55	0.88	disease	0.91	disease	0.67	disease	0.63	disease	3	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.36	high_impact	0.42	0.9	3.9	6.65	0.58	P	0.83	disease_causing	0.56	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6888	6888	G	C	MI.3984	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	985	329	G	R	Gga/Cga	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-1.74	deleterious	-5.2	medium_impact	3.42	0.61	neutral	0.07	damaging	4.06	23.70	deleterious	0.2	0.55	0.31	neutral	0.88	disease	0.63	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.06	high_impact	0.76	0.9	3.9	6.65	0.28	N	0.95	polymorphism	0.56	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6889	6889	G	C	MI.3985	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	986	329	G	A	gGa/gCa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-3.38	deleterious	-3.9	high_impact	4.28	0.78	neutral	0.14	damaging	3.20	22.70	deleterious	0.27	0.55	0.21	neutral	0.73	disease	0.56	disease	0.51	disease	0	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.85	high_impact	0.65	0.9	3.9	6.65	0.44	N	0.64	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6889	6889	G	A	MI.3986	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	986	329	G	E	gGa/gAa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.1	deleterious	-5.2	high_impact	4.28	0.5	damaging	0.12	damaging	3.95	23.60	deleterious	0.22	0.55	0.24	neutral	0.88	disease	0.62	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.85	high_impact	0.56	0.9	3.9	6.65	0.44	N	0.93	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6889	6889	G	T	MI.3987	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	986	329	G	V	gGa/gTa	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.23	deleterious	-5.85	high_impact	5.17	0.61	neutral	0.09	damaging	3.81	23.40	deleterious	0.17	0.55	0.42	neutral	0.87	disease	0.6	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.49	0.9	3.9	6.65	0.61	P	0.93	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6891	6891	A	G	MI.3988	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	988	330	S	G	Agc/Ggc	-3.11	0	0	benign	0	neutral	1	neutral	3.15	neutral	1.75	neutral	-1.52	low_impact	1.46	0.75	neutral	0.99	neutral	-0.69	0.08	neutral	0.34	0.55	0.42	neutral	0.19	neutral	0.14	neutral	0.36	neutral	3	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	1.86	high_impact	0.25	medium_impact	0.81	0.9	7.21	28.88	0.44	N	0.00	polymorphism	1	0.04	rs879091068	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	6891	6891	A	C	MI.3989	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	988	330	S	R	Agc/Cgc	-3.11	0	0	benign	0	deleterious	0.01	neutral	2.9	neutral	-1.12	neutral	-2.2	high_impact	3.51	0.61	neutral	0.59	neutral	2.03	16.40	deleterious	0.25	0.55	0.44	neutral	0.84	disease	0.48	neutral	0.63	disease	3	0.99	deleterious	0.51	deleterious	2	deleterious	0.24	neutral	2.07	high_impact	-0.92	medium_impact	2.14	high_impact	0.80	0.9	7.21	28.88	0.42	N	0.49	polymorphism	0.99	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8712	8712	C	A	MI.399	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	186	62	N	K	aaC/aaA	0.59	0	0	benign	0.28	neutral	0.41	neutral	4.45	neutral	0.61	deleterious	-4.78	low_impact	1.54	0.75	neutral	0.49	neutral	2.46	19.20	deleterious	0.89	0.9	0.35	neutral	0.76	disease	0.36	neutral	0.52	disease	0	0.5	neutral	0.57	deleterious	-6	neutral	0.39	neutral	-0.37	medium_impact	0.2	medium_impact	0.22	medium_impact	0.78	0.9	18.14	14.91	0.32	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6891	6891	A	T	MI.3990	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	988	330	S	C	Agc/Tgc	-3.11	0	0	benign	0.1	deleterious	0.04	neutral	2.81	deleterious	-4.12	neutral	-2.19	medium_impact	3.44	0.56	damaging	0.47	neutral	1.67	14.25	neutral	0.28	0.55	0.65	disease	0.8	disease	0.36	neutral	0.62	disease	2	0.96	neutral	0.47	deleterious	1	deleterious	0.37	neutral	0.14	medium_impact	-0.58	medium_impact	2.08	high_impact	0.74	0.9	7.21	28.88	0.4	N	0.55	polymorphism	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6892	6892	G	C	MI.3991	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	989	330	S	T	aGc/aCc	5.22	1	0	benign	0	neutral	0.34	neutral	2.87	neutral	-1.05	neutral	-0.48	low_impact	1.04	0.65	neutral	0.76	neutral	-0.43	0.33	neutral	0.32	0.55	0.28	neutral	0.25	neutral	0.15	neutral	0.44	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	0.03	medium_impact	-0.14	medium_impact	0.78	0.9	7.21	28.88	0.67	P	0.32	polymorphism	0.66	0.04	.	.	.	.	.	.	COSM5656135	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6892	6892	G	A	MI.3992	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	989	330	S	N	aGc/aAc	5.22	1	0	benign	0	deleterious	0.01	neutral	2.88	neutral	-1.15	neutral	-1.32	medium_impact	2.79	0.68	neutral	0.78	neutral	0.70	8.83	deleterious	0.55	0.6	0.44	neutral	0.7	disease	0.4	neutral	0.33	neutral	3	0.99	deleterious	0.51	deleterious	1	deleterious	0.19	neutral	2.07	high_impact	-0.92	medium_impact	1.48	medium_impact	0.64	0.9	7.21	28.88	0.57	P	0.23	polymorphism	0.61	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6892	6892	G	T	MI.3993	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	989	330	S	I	aGc/aTc	5.22	1	0	benign	0.02	deleterious	0.02	neutral	2.83	neutral	-2.31	neutral	-2.49	medium_impact	2.9	0.6	neutral	0.65	neutral	1.22	11.84	neutral	0.26	0.55	0.42	neutral	0.86	disease	0.37	neutral	0.45	neutral	1	0.98	neutral	0.5	deleterious	1	deleterious	0.23	neutral	0.83	medium_impact	-0.75	medium_impact	1.58	medium_impact	0.84	0.9	7.21	28.88	0.55	P	0.59	disease_causing	0.83	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6894	6894	A	T	MI.3994	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	991	331	N	Y	Aat/Tat	-12.6	0	0	probably_damaging	0.95	neutral	0.17	neutral	2.75	deleterious	-3.18	neutral	0.07	neutral_impact	-0.02	0.78	neutral	0.49	neutral	2.05	16.56	deleterious	0.41	0.55	0.58	disease	0.32	neutral	0.18	neutral	0.6	disease	2	0.97	neutral	0.11	neutral	-2	neutral	0.67	deleterious	-1.96	low_impact	-0.19	medium_impact	-1.12	low_impact	0.53	0.9	11.89	12.58	0.48	N	0.93	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6894	6894	A	C	MI.3995	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	991	331	N	H	Aat/Cat	-12.6	0	0	possibly_damaging	0.88	neutral	0.21	neutral	2.77	neutral	-1.96	neutral	0.06	neutral_impact	0.68	0.79	neutral	0.55	neutral	1.65	14.11	neutral	0.65	0.7	0.46	neutral	0.24	neutral	0.19	neutral	0.46	neutral	1	0.92	neutral	0.17	neutral	-3	neutral	0.60	deleterious	-1.57	low_impact	-0.13	medium_impact	-0.47	medium_impact	0.55	0.9	11.89	12.58	0.5	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6894	6894	A	G	MI.3996	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	991	331	N	D	Aat/Gat	-12.6	0	0	benign	0.01	neutral	0.3	neutral	2.8	neutral	-0.71	neutral	-0.63	low_impact	1.52	0.81	neutral	0.62	neutral	0.79	9.39	deleterious	0.76	0.8	0.27	neutral	0.34	neutral	0.27	neutral	0.45	neutral	1	0.69	neutral	0.65	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	-0.01	medium_impact	0.3	medium_impact	0.61	0.9	11.89	12.58	0.47	N	0.92	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6895	6895	A	G	MI.3997	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	992	331	N	S	aAt/aGt	0.59	0	0	benign	0.1	neutral	0.82	neutral	2.86	neutral	0.41	neutral	-0.12	neutral_impact	-0.6	0.74	neutral	0.75	neutral	-0.48	0.25	neutral	0.71	0.75	0.2	neutral	0.11	neutral	0.11	neutral	0.24	neutral	5	0.08	neutral	0.86	deleterious	-6	neutral	0.14	neutral	0.14	medium_impact	0.56	medium_impact	-1.65	low_impact	0.33	0.9	11.89	12.58	0.39	N	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6895	6895	A	C	MI.3998	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	992	331	N	T	aAt/aCt	0.59	0	0	benign	0.4	neutral	0.51	neutral	2.8	neutral	-1.04	neutral	-0.52	neutral_impact	0.71	0.71	neutral	0.63	neutral	0.16	4.30	deleterious	0.5	0.55	0.28	neutral	0.2	neutral	0.25	neutral	0.36	neutral	3	0.43	neutral	0.56	deleterious	-6	neutral	0.34	neutral	-0.59	medium_impact	0.2	medium_impact	-0.44	medium_impact	0.56	0.9	11.89	12.58	0.39	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6895	6895	A	T	MI.3999	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	992	331	N	I	aAt/aTt	0.59	0	0	probably_damaging	0.92	neutral	0.25	neutral	2.75	neutral	-2.91	neutral	-1.4	low_impact	0.83	0.75	neutral	0.61	neutral	2.59	20.10	deleterious	0.38	0.55	0.54	disease	0.5	disease	0.27	neutral	0.29	neutral	4	0.94	neutral	0.17	neutral	-2	neutral	0.67	deleterious	-1.76	low_impact	-0.07	medium_impact	-0.33	medium_impact	0.49	0.9	11.89	12.58	0.38	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8528	8528	T	C	MI.4	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	2	1	M	T	aTg/aCg	5.68	1	0	possibly_damaging	0.8	deleterious	0	neutral	4.49	neutral	-0.97	deleterious	-4.97	NA	NA	0.7	neutral	0.13	damaging	3.65	23.20	deleterious	0.47	0.65	0.58	disease	0.5	neutral	0.65	disease	0.66	disease	3	1	deleterious	0.1	neutral	3	deleterious	0.76	deleterious	NA	NA	NA	NA	NA	NA	0.24	0.9	50	8.74	0.63	P	0.97	NA	NA	0.31	rs387906422	Pathogenic	Cardiomyopathy,_infantile_hypertrophic	24679	MedGen:C2748884,OMIM:500006	.	.	.	.	T8528C	Infantile cardiomyopathy	+	+	Cfrm	3	P	P	P	damaging
chrM	8543	8543	T	G	MI.40	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	17	6	F	C	tTc/tGc	4.76	1	0	probably_damaging	0.99	deleterious	0	neutral	3.87	deleterious	-3.88	deleterious	-6.74	medium_impact	3.32	0.58	damaging	0.53	neutral	4.06	23.70	deleterious	0.31	0.65	0.92	disease	0.72	disease	0.82	disease	0.87	disease	7	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-2.65	low_impact	-1.4	low_impact	1.75	medium_impact	0.19	0.9	39.82	8.43	0.58	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8712	8712	C	G	MI.400	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	186	62	N	K	aaC/aaG	0.59	0	0	benign	0.28	neutral	0.41	neutral	4.45	neutral	0.61	deleterious	-4.78	low_impact	1.54	0.75	neutral	0.49	neutral	2.01	16.29	deleterious	0.89	0.9	0.35	neutral	0.76	disease	0.36	neutral	0.52	disease	0	0.5	neutral	0.57	deleterious	-6	neutral	0.39	neutral	-0.37	medium_impact	0.2	medium_impact	0.22	medium_impact	0.78	0.9	18.14	14.91	0.32	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6896	6896	T	G	MI.4000	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	993	331	N	K	aaT/aaG	1.98	0	0	possibly_damaging	0.54	neutral	1	neutral	2.96	neutral	0.15	neutral	0.88	neutral_impact	-1.42	0.73	neutral	0.54	neutral	-0.08	1.92	neutral	0.73	0.75	0.18	neutral	0.13	neutral	0.14	neutral	0.24	neutral	5	0.54	neutral	0.73	deleterious	-3	neutral	0.47	deleterious	-0.82	medium_impact	1.86	high_impact	-2.41	low_impact	0.71	0.9	11.89	12.58	0.35	N	0.92	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6896	6896	T	A	MI.4001	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	993	331	N	K	aaT/aaA	1.98	0	0	possibly_damaging	0.54	neutral	1	neutral	2.96	neutral	0.15	neutral	0.88	neutral_impact	-1.42	0.73	neutral	0.54	neutral	0.25	5.15	deleterious	0.73	0.75	0.18	neutral	0.13	neutral	0.14	neutral	0.24	neutral	5	0.54	neutral	0.73	deleterious	-3	neutral	0.47	deleterious	-0.82	medium_impact	1.86	high_impact	-2.41	low_impact	0.71	0.9	11.89	12.58	0.36	N	0.92	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6897	6897	A	C	MI.4002	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	994	332	M	L	Atg/Ctg	-6.12	0	0	benign	0	neutral	0.46	neutral	3.05	neutral	2.33	neutral	0.31	neutral_impact	-1.73	0.66	neutral	0.81	neutral	-0.39	0.41	neutral	0.48	0.55	0.26	neutral	0.33	neutral	0.22	neutral	0.44	neutral	1	0.54	neutral	0.73	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.15	medium_impact	-2.7	low_impact	0.55	0.9	7.99	24.73	0.44	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6897	6897	A	G	MI.4003	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	994	332	M	V	Atg/Gtg	-6.12	0	0	benign	0	neutral	0.21	neutral	2.9	neutral	1.27	neutral	0	neutral_impact	-0.78	0.75	neutral	0.86	neutral	-0.46	0.27	neutral	0.49	0.55	0.26	neutral	0.42	neutral	0.23	neutral	0.44	neutral	1	0.79	neutral	0.61	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	-0.13	medium_impact	-1.82	low_impact	0.42	0.9	7.99	24.73	0.47	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6897	6897	A	T	MI.4004	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	994	332	M	L	Atg/Ttg	-6.12	0	0	benign	0	neutral	0.46	neutral	3.05	neutral	2.33	neutral	0.31	neutral_impact	-1.73	0.66	neutral	0.81	neutral	-0.38	0.44	neutral	0.48	0.55	0.26	neutral	0.33	neutral	0.22	neutral	0.44	neutral	1	0.54	neutral	0.73	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.15	medium_impact	-2.7	low_impact	0.55	0.9	7.99	24.73	0.45	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6898	6898	T	C	MI.4005	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	995	332	M	T	aTg/aCg	4.76	0.99	0	benign	0	neutral	0.09	neutral	2.82	neutral	-0.4	neutral	-1.54	low_impact	0.95	0.7	neutral	0.91	neutral	1.08	11.10	neutral	0.38	0.55	0.27	neutral	0.52	disease	0.42	neutral	0.22	neutral	6	0.91	neutral	0.55	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	-0.37	medium_impact	-0.22	medium_impact	0.18	0.9	7.99	24.73	0.61	P	0.00	polymorphism	0.62	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6898	6898	T	A	MI.4006	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	995	332	M	K	aTg/aAg	4.76	0.99	0	benign	0	deleterious	0.01	neutral	2.77	neutral	-1.65	neutral	-2.4	neutral_impact	0.68	0.58	damaging	0.51	neutral	2.09	16.76	deleterious	0.23	0.55	0.45	neutral	0.71	disease	0.45	neutral	0.35	neutral	3	0.99	deleterious	0.51	deleterious	-2	neutral	0.23	neutral	2.07	high_impact	-0.92	medium_impact	-0.47	medium_impact	0.49	0.9	7.99	24.73	0.5	P	0.32	disease_causing	0.82	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6899	6899	G	C	MI.4007	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	996	332	M	I	atG/atC	3.83	1	0.01	benign	0	neutral	1	neutral	3	neutral	2.13	neutral	0.49	neutral_impact	-1.9	0.77	neutral	1	neutral	-0.93	0.02	neutral	0.58	0.65	0.32	neutral	0.18	neutral	0.15	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	1.86	high_impact	-2.85	low_impact	0.52	0.9	7.99	24.73	0.46	N	0.00	polymorphism	0.97	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6899	6899	G	T	MI.4008	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	996	332	M	I	atG/atT	3.83	1	0.01	benign	0	neutral	1	neutral	3	neutral	2.13	neutral	0.49	neutral_impact	-1.9	0.77	neutral	1	neutral	-0.83	0.04	neutral	0.58	0.65	0.32	neutral	0.18	neutral	0.15	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	1.86	high_impact	-2.85	low_impact	0.52	0.9	7.99	24.73	0.45	N	0.00	polymorphism	0.97	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6900	6900	A	C	MI.4009	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	997	333	K	Q	Aaa/Caa	-4.27	0	0	benign	0.08	neutral	0.05	neutral	2.89	neutral	-0.55	neutral	-0.66	low_impact	1.83	0.69	neutral	0.21	damaging	0.38	6.44	deleterious	0.51	0.6	0.28	neutral	0.58	disease	0.23	neutral	0.21	neutral	6	0.95	neutral	0.49	deleterious	-6	neutral	0.27	neutral	0.24	medium_impact	-0.52	medium_impact	0.59	medium_impact	0.70	0.9	11.11	8.78	0.44	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8713	8713	A	T	MI.401	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	187	63	T	S	Act/Tct	-2.42	0	0	benign	0.07	neutral	0.76	neutral	3.98	neutral	1.07	neutral	-1.04	neutral_impact	0.16	0.87	neutral	0.82	neutral	-0.88	0.03	neutral	0.67	0.75	0.33	neutral	0.22	neutral	0.14	neutral	0.42	neutral	2	0.15	neutral	0.85	deleterious	-6	neutral	0.12	neutral	0.31	medium_impact	0.57	medium_impact	-0.96	medium_impact	0.80	0.9	18.58	14.48	0.39	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6900	6900	A	G	MI.4010	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	997	333	K	E	Aaa/Gaa	-4.27	0	0	benign	0.06	deleterious	0.02	neutral	2.9	neutral	-0.41	neutral	-0.74	medium_impact	1.97	0.63	neutral	0.18	damaging	1.07	11.06	neutral	0.39	0.55	0.29	neutral	0.75	disease	0.28	neutral	0.23	neutral	5	0.98	neutral	0.48	deleterious	1	deleterious	0.28	neutral	0.37	medium_impact	-0.75	medium_impact	0.72	medium_impact	0.63	0.9	11.11	8.78	0.39	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6901	6901	A	C	MI.4011	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	998	333	K	T	aAa/aCa	7.07	1	0	benign	0	neutral	0.09	neutral	2.94	neutral	-0.78	neutral	-0.85	low_impact	1.29	0.67	neutral	0.22	damaging	0.46	7.10	deleterious	0.29	0.55	0.41	neutral	0.47	neutral	0.34	neutral	0.34	neutral	3	0.91	neutral	0.55	deleterious	-6	neutral	0.18	neutral	2.07	high_impact	-0.37	medium_impact	0.09	medium_impact	0.58	0.9	11.11	8.78	0.61	P	0.76	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6901	6901	A	T	MI.4012	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	998	333	K	M	aAa/aTa	7.07	1	0	possibly_damaging	0.52	deleterious	0.04	neutral	2.88	deleterious	-3.52	neutral	-1.5	medium_impact	2.44	0.68	neutral	0.16	damaging	2.43	19.04	deleterious	0.34	0.55	0.66	disease	0.56	disease	0.26	neutral	0.25	neutral	5	0.96	neutral	0.26	neutral	4	deleterious	0.50	deleterious	-0.79	medium_impact	-0.58	medium_impact	1.15	medium_impact	0.57	0.9	11.11	8.78	0.49	P	0.89	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6902	6902	A	C	MI.4013	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	999	333	K	N	aaA/aaC	5.68	1	0	benign	0.14	neutral	0.39	neutral	2.91	neutral	-1.25	neutral	0.18	neutral_impact	0.34	0.66	neutral	0.39	neutral	0.31	5.78	deleterious	0.64	0.65	0.42	neutral	0.4	neutral	0.24	neutral	0.46	neutral	1	0.54	neutral	0.63	deleterious	-6	neutral	0.41	neutral	-0.01	medium_impact	0.09	medium_impact	-0.79	medium_impact	0.87	0.9	11.11	8.78	0.56	P	0.76	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6902	6902	A	T	MI.4014	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	999	333	K	N	aaA/aaT	5.68	1	0	benign	0.14	neutral	0.39	neutral	2.91	neutral	-1.25	neutral	0.18	neutral_impact	0.34	0.66	neutral	0.39	neutral	0.31	5.79	deleterious	0.64	0.65	0.42	neutral	0.4	neutral	0.24	neutral	0.46	neutral	1	0.54	neutral	0.63	deleterious	-6	neutral	0.41	neutral	-0.01	medium_impact	0.09	medium_impact	-0.79	medium_impact	0.87	0.9	11.11	8.78	0.55	P	0.76	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6903	6903	T	G	MI.4015	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1000	334	W	G	Tga/Gga	1.29	1	0	probably_damaging	0.99	deleterious	0.01	neutral	2.75	deleterious	-3.24	deleterious	-3.13	low_impact	1.68	0.56	damaging	0.06	damaging	4.01	23.60	deleterious	0.35	0.55	0.46	neutral	0.59	disease	0.6	disease	0.68	disease	4	1	deleterious	0.01	neutral	2	deleterious	0.74	deleterious	-2.64	low_impact	-0.92	medium_impact	0.45	medium_impact	0.41	0.9	2.34	6.98	0.3	N	0.89	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6903	6903	T	C	MI.4016	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1000	334	W	R	Tga/Cga	1.29	1	0	probably_damaging	1	neutral	0.14	neutral	2.76	deleterious	-3.11	deleterious	-2.79	low_impact	1.62	0.51	damaging	0.04	damaging	3.69	23.30	deleterious	0.47	0.55	0.29	neutral	0.73	disease	0.61	disease	0.7	disease	4	1	deleterious	0.07	neutral	-2	neutral	0.75	deleterious	-3.58	low_impact	-0.25	medium_impact	0.4	medium_impact	0.35	0.9	2.34	6.98	0.31	N	0.98	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6904	6904	G	C	MI.4017	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1001	334	W	S	tGa/tCa	5.91	1	0	probably_damaging	1	neutral	0.05	neutral	2.78	neutral	-2.18	deleterious	-2.5	low_impact	1.22	0.52	damaging	0.06	damaging	3.01	22.30	deleterious	0.31	0.55	0.31	neutral	0.6	disease	0.56	disease	0.33	neutral	3	1	deleterious	0.03	neutral	-2	neutral	0.73	deleterious	-3.58	low_impact	-0.52	medium_impact	0.03	medium_impact	0.44	0.9	2.34	6.98	0.43	N	0.89	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6904	6904	G	T	MI.4018	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1001	334	W	L	tGa/tTa	5.91	1	0	probably_damaging	0.99	neutral	0.16	neutral	2.89	neutral	0.29	neutral	-1.34	neutral_impact	-0.86	0.54	damaging	0.04	damaging	3.06	22.40	deleterious	0.3	0.55	0.22	neutral	0.4	neutral	0.3	neutral	0.43	neutral	1	0.99	deleterious	0.09	neutral	-2	neutral	0.68	deleterious	-2.64	low_impact	-0.21	medium_impact	-1.89	low_impact	0.26	0.9	2.34	6.98	0.51	N	0.95	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6905	6905	A	T	MI.4019	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1002	334	W	C	tgA/tgT	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.57	neutral	-2.42	medium_impact	2.31	0.52	damaging	0.04	damaging	4.21	23.90	deleterious	0.39	0.55	0.5	disease	0.77	disease	0.66	disease	0.73	disease	5	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	1.03	medium_impact	0.33	0.9	2.34	6.98	0.42	N	0.88	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8713	8713	A	G	MI.402	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	187	63	T	A	Act/Gct	-2.42	0	0	benign	0	neutral	0.75	neutral	3.92	neutral	0.25	neutral	-1.01	neutral_impact	0.64	0.97	neutral	0.96	neutral	-0.96	0.02	neutral	0.63	0.7	0.28	neutral	0.26	neutral	0.27	neutral	0.42	neutral	2	0.24	neutral	0.88	deleterious	-6	neutral	0.09	neutral	2.09	high_impact	0.56	medium_impact	-0.55	medium_impact	0.36	0.9	18.58	14.48	0.34	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6905	6905	A	C	MI.4020	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1002	334	W	C	tgA/tgC	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.57	neutral	-2.42	medium_impact	2.31	0.52	damaging	0.04	damaging	4.16	23.80	deleterious	0.39	0.55	0.5	disease	0.77	disease	0.66	disease	0.73	disease	5	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	1.03	medium_impact	0.33	0.9	2.34	6.98	0.42	N	0.88	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6906	6906	T	A	MI.4021	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1003	335	S	T	Tct/Act	2.21	1	0	benign	0.15	neutral	0.14	neutral	2.93	neutral	-0.67	neutral	-1	neutral_impact	0.72	0.69	neutral	0.25	damaging	0.78	9.32	deleterious	0.53	0.6	0.16	neutral	0.38	neutral	0.14	neutral	0.45	neutral	1	0.84	neutral	0.5	deleterious	-6	neutral	0.16	neutral	-0.05	medium_impact	-0.25	medium_impact	-0.43	medium_impact	0.83	0.9	10.92	10.49	0.51	P	0.43	polymorphism	0.7	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6906	6906	T	C	MI.4022	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1003	335	S	P	Tct/Cct	2.21	1	0	possibly_damaging	0.73	deleterious	0.02	neutral	2.83	neutral	-2.52	neutral	-2.01	medium_impact	2.77	0.51	damaging	0.09	damaging	3.86	23.50	deleterious	0.32	0.55	0.53	disease	0.9	disease	0.32	neutral	0.52	disease	0	0.98	deleterious	0.15	neutral	4	deleterious	0.65	deleterious	-1.16	low_impact	-0.75	medium_impact	1.46	medium_impact	0.71	0.9	10.92	10.49	0.4	N	0.91	disease_causing	0.73	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6906	6906	T	G	MI.4023	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1003	335	S	A	Tct/Gct	2.21	1	0	benign	0.01	deleterious	0.03	neutral	2.85	neutral	-1.91	neutral	-1.55	medium_impact	2.57	0.71	neutral	0.57	neutral	0.80	9.45	deleterious	0.53	0.6	0.27	neutral	0.58	disease	0.28	neutral	0.4	neutral	2	0.97	neutral	0.51	deleterious	1	deleterious	0.17	neutral	1.12	medium_impact	-0.65	medium_impact	1.27	medium_impact	0.68	0.9	10.92	10.49	0.55	P	0.35	polymorphism	0.89	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6907	6907	C	G	MI.4024	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1004	335	S	C	tCt/tGt	2.9	1	0	probably_damaging	0.92	deleterious	0	neutral	2.8	deleterious	-5.28	deleterious	-2.65	high_impact	3.81	0.57	damaging	0.11	damaging	3.57	23.20	deleterious	0.38	0.55	0.79	disease	0.84	disease	0.22	neutral	0.68	disease	4	1	deleterious	0.04	neutral	6	deleterious	0.73	deleterious	-1.76	low_impact	-1.48	low_impact	2.42	high_impact	0.82	0.9	10.92	10.49	0.38	N	0.85	polymorphism	0.88	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6907	6907	C	T	MI.4025	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1004	335	S	F	tCt/tTt	2.9	1	0	probably_damaging	0.96	deleterious	0	neutral	2.8	deleterious	-4.38	deleterious	-2.86	high_impact	3.81	0.6	damaging	0.09	damaging	4.15	23.80	deleterious	0.37	0.55	0.67	disease	0.86	disease	0.21	neutral	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-2.06	low_impact	-1.48	low_impact	2.42	high_impact	0.38	0.9	10.92	10.49	0.38	N	0.98	polymorphism	0.71	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6907	6907	C	A	MI.4026	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1004	335	S	Y	tCt/tAt	2.9	1	0	probably_damaging	0.96	deleterious	0.01	neutral	2.81	deleterious	-3.58	deleterious	-2.63	medium_impact	3.19	0.63	neutral	0.1	damaging	4.13	23.80	deleterious	0.36	0.55	0.61	disease	0.86	disease	0.19	neutral	0.54	disease	1	1	deleterious	0.03	neutral	5	deleterious	0.78	deleterious	-2.06	low_impact	-0.92	medium_impact	1.85	medium_impact	0.72	0.9	10.92	10.49	0.4	N	0.92	polymorphism	0.81	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6909	6909	G	T	MI.4027	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1006	336	A	S	Gct/Tct	-5.42	0	0	benign	0.13	deleterious	0.03	neutral	2.93	neutral	-0.96	neutral	0.01	neutral_impact	0.2	0.75	neutral	0.71	neutral	1.92	15.69	deleterious	0.38	0.55	0.19	neutral	0.51	disease	0.09	neutral	0.27	neutral	5	0.97	neutral	0.45	neutral	-2	neutral	0.21	neutral	0.02	medium_impact	-0.65	medium_impact	-0.91	medium_impact	0.74	0.9	10.14	27.75	0.56	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6909	6909	G	A	MI.4028	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1006	336	A	T	Gct/Act	-5.42	0	0	benign	0.18	neutral	0.74	neutral	3	neutral	0.05	neutral	0.39	neutral_impact	-0.55	0.64	neutral	0.72	neutral	0.91	10.12	neutral	0.3	0.55	0.18	neutral	0.23	neutral	0.1	neutral	0.42	neutral	2	0.15	neutral	0.78	deleterious	-6	neutral	0.20	neutral	-0.14	medium_impact	0.45	medium_impact	-1.61	low_impact	0.56	0.9	10.14	27.75	0.37	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6909	6909	G	C	MI.4029	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1006	336	A	P	Gct/Cct	-5.42	0	0	benign	0	neutral	1	neutral	3.17	neutral	1.18	neutral	1.93	neutral_impact	-1.57	0.74	neutral	0.97	neutral	-0.68	0.08	neutral	0.16	0.55	0.25	neutral	0.27	neutral	0.11	neutral	0.42	neutral	2	0	neutral	1	deleterious	-6	neutral	0.17	neutral	2.07	high_impact	1.86	high_impact	-2.55	low_impact	0.68	0.9	10.14	27.75	0.38	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8713	8713	A	C	MI.403	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	187	63	T	P	Act/Cct	-2.42	0	0	benign	0	neutral	0.77	neutral	3.92	neutral	0.23	neutral	-1.3	neutral_impact	-0.55	0.94	neutral	0.99	neutral	-0.94	0.02	neutral	0.33	0.65	0.31	neutral	0.46	neutral	0.11	neutral	0.44	neutral	1	0.22	neutral	0.89	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.59	medium_impact	-1.57	low_impact	0.64	0.9	18.58	14.48	0.37	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6910	6910	C	T	MI.4030	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1007	336	A	V	gCt/gTt	2.44	0.98	0	benign	0.23	neutral	0.08	neutral	2.98	neutral	-0.17	neutral	-0.68	neutral_impact	0.02	0.76	neutral	0.68	neutral	1.76	14.74	neutral	0.19	0.55	0.23	neutral	0.54	disease	0.13	neutral	0.23	neutral	5	0.91	neutral	0.43	neutral	-6	neutral	0.23	neutral	-0.26	medium_impact	-0.4	medium_impact	-1.08	low_impact	0.63	0.9	10.14	27.75	0.54	P	0.63	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6910	6910	C	G	MI.4031	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1007	336	A	G	gCt/gGt	2.44	0.98	0	benign	0.18	deleterious	0	neutral	2.89	neutral	-2.19	neutral	-1.09	low_impact	1.72	0.68	neutral	0.57	neutral	2.33	18.39	deleterious	0.22	0.55	0.46	neutral	0.59	disease	0.21	neutral	0.45	neutral	1	1	deleterious	0.41	neutral	-2	neutral	0.27	neutral	-0.14	medium_impact	-1.48	low_impact	0.49	medium_impact	0.66	0.9	10.14	27.75	0.52	P	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6910	6910	C	A	MI.4032	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1007	336	A	D	gCt/gAt	2.44	0.98	0	benign	0.33	neutral	0.14	neutral	2.87	neutral	-2.95	neutral	-0.78	low_impact	1.82	0.65	neutral	0.45	neutral	2.92	21.90	deleterious	0.19	0.55	0.41	neutral	0.86	disease	0.39	neutral	0.69	disease	4	0.83	neutral	0.41	neutral	-6	neutral	0.38	neutral	-0.47	medium_impact	-0.25	medium_impact	0.58	medium_impact	0.49	0.9	10.14	27.75	0.51	N	0.48	polymorphism	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6912	6912	G	A	MI.4033	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1009	337	A	T	Gca/Aca	-16.07	0	0	probably_damaging	1	neutral	0.11	neutral	2.7	neutral	-1.48	neutral	-0.37	low_impact	1.03	0.68	neutral	0.17	damaging	3.21	22.70	deleterious	0.43	0.55	0.33	neutral	0.52	disease	0.22	neutral	0.28	neutral	4	1	deleterious	0.06	neutral	-2	neutral	0.72	deleterious	-3.58	low_impact	-0.31	medium_impact	-0.15	medium_impact	0.72	0.9	4.87	10.37	0.41	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6912	6912	G	C	MI.4034	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1009	337	A	P	Gca/Cca	-16.07	0	0	probably_damaging	1	neutral	1	neutral	2.84	neutral	0.8	neutral	0.84	neutral_impact	-1.01	0.66	neutral	0.4	neutral	1.24	11.95	neutral	0.18	0.55	0.23	neutral	0.38	neutral	0.34	neutral	0.43	neutral	2	1	deleterious	0.5	deleterious	-2	neutral	0.70	deleterious	-3.58	low_impact	1.86	high_impact	-2.03	low_impact	0.78	0.9	4.87	10.37	0.27	N	0.85	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6912	6912	G	T	MI.4035	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1009	337	A	S	Gca/Tca	-16.07	0	0	probably_damaging	1	neutral	0.32	neutral	2.67	neutral	-1.28	neutral	0.36	neutral_impact	-0.87	0.65	neutral	0.24	damaging	1.69	14.33	neutral	0.44	0.55	0.24	neutral	0.2	neutral	0.24	neutral	0.35	neutral	3	1	deleterious	0.16	neutral	-2	neutral	0.68	deleterious	-3.58	low_impact	0.01	medium_impact	-1.9	low_impact	0.81	0.9	4.87	10.37	0.38	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6913	6913	C	T	MI.4036	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1010	337	A	V	gCa/gTa	4.06	1	0	probably_damaging	1	neutral	0.06	neutral	2.73	neutral	-1.87	neutral	-1.41	medium_impact	1.99	0.66	neutral	0.16	damaging	4.47	24.20	deleterious	0.37	0.55	0.41	neutral	0.68	disease	0.3	neutral	0.25	neutral	5	1	deleterious	0.03	neutral	1	deleterious	0.74	deleterious	-3.58	low_impact	-0.47	medium_impact	0.74	medium_impact	0.75	0.9	4.87	10.37	0.52	P	0.75	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6913	6913	C	A	MI.4037	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1010	337	A	E	gCa/gAa	4.06	1	0	probably_damaging	1	deleterious	0.04	neutral	2.69	neutral	-1.21	neutral	-0.87	medium_impact	1.95	0.59	damaging	0.13	damaging	4.47	24.20	deleterious	0.21	0.55	0.16	neutral	0.85	disease	0.6	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-0.58	medium_impact	0.7	medium_impact	0.64	0.9	4.87	10.37	0.4	N	0.76	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6913	6913	C	G	MI.4038	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1010	337	A	G	gCa/gGa	4.06	1	0	probably_damaging	1	deleterious	0.01	neutral	2.61	neutral	-1.96	neutral	-1.05	medium_impact	2.72	0.65	neutral	0.15	damaging	4.02	23.60	deleterious	0.31	0.55	0.45	neutral	0.65	disease	0.52	disease	0.58	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.74	deleterious	-3.58	low_impact	-0.92	medium_impact	1.41	medium_impact	0.66	0.9	4.87	10.37	0.46	N	0.56	disease_causing	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6915	6915	G	A	MI.4039	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1012	338	V	M	Gtg/Atg	-15.6	0	0	benign	0	neutral	1	neutral	2.86	neutral	1.96	neutral	1.04	neutral_impact	-1.96	0.76	neutral	0.99	neutral	-0.91	0.03	neutral	0.4	0.55	0.28	neutral	0.12	neutral	0.14	neutral	0.29	neutral	4	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	1.86	high_impact	-2.91	low_impact	0.97	1	10.33	30.3	0.42	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8714	8714	C	A	MI.404	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	188	63	T	N	aCt/aAt	-4.5	0	0	benign	0.28	neutral	0.58	neutral	3.96	neutral	0.89	neutral	-1.81	neutral_impact	0.73	0.9	neutral	0.86	neutral	-0.06	2.08	deleterious	0.71	0.75	0.42	neutral	0.42	neutral	0.25	neutral	0.46	neutral	1	0.32	neutral	0.65	deleterious	-6	neutral	0.25	neutral	-0.37	medium_impact	0.37	medium_impact	-0.47	medium_impact	0.78	0.9	18.58	14.48	0.32	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6915	6915	G	C	MI.4040	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1012	338	V	L	Gtg/Ctg	-15.6	0	0	benign	0	neutral	0.92	neutral	2.89	neutral	1.1	neutral	0.86	neutral_impact	-1.56	0.76	neutral	0.97	neutral	-0.70	0.07	neutral	0.36	0.55	0.16	neutral	0.39	neutral	0.19	neutral	0.44	neutral	1	0.07	neutral	0.96	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.78	medium_impact	-2.54	low_impact	0.66	0.9	10.33	30.3	0.35	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6915	6915	G	T	MI.4041	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1012	338	V	L	Gtg/Ttg	-15.6	0	0	benign	0	neutral	0.92	neutral	2.89	neutral	1.1	neutral	0.86	neutral_impact	-1.56	0.76	neutral	0.97	neutral	-0.60	0.13	neutral	0.36	0.55	0.16	neutral	0.39	neutral	0.19	neutral	0.44	neutral	1	0.07	neutral	0.96	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.78	medium_impact	-2.54	low_impact	0.66	0.9	10.33	30.3	0.35	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6916	6916	T	C	MI.4042	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1013	338	V	A	gTg/gCg	0.82	0.23	0	benign	0.02	neutral	0.06	neutral	2.74	neutral	-0.27	neutral	-1.23	neutral_impact	0.78	0.67	neutral	0.75	neutral	1.71	14.45	neutral	0.36	0.55	0.25	neutral	0.52	disease	0.33	neutral	0.42	neutral	2	0.94	neutral	0.52	deleterious	-6	neutral	0.18	neutral	0.83	medium_impact	-0.47	medium_impact	-0.38	medium_impact	0.68	0.9	10.33	30.3	0.45	N	0.10	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6916	6916	T	A	MI.4043	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1013	338	V	E	gTg/gAg	0.82	0.23	0	benign	0.06	deleterious	0.01	neutral	2.65	neutral	-2.01	neutral	-2.2	low_impact	1.6	0.63	neutral	0.56	neutral	2.96	22.10	deleterious	0.16	0.55	0.25	neutral	0.87	disease	0.61	disease	0.75	disease	5	0.99	deleterious	0.48	deleterious	-2	neutral	0.25	neutral	0.37	medium_impact	-0.92	medium_impact	0.38	medium_impact	0.61	0.9	10.33	30.3	0.34	N	0.27	polymorphism	0.71	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6916	6916	T	G	MI.4044	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1013	338	V	G	gTg/gGg	0.82	0.23	0	benign	0.04	deleterious	0.01	neutral	2.69	neutral	-2.14	deleterious	-2.82	low_impact	1.72	0.65	neutral	0.51	neutral	1.98	16.08	deleterious	0.2	0.55	0.17	neutral	0.7	disease	0.47	neutral	0.48	neutral	0	0.99	deleterious	0.49	deleterious	-2	neutral	0.18	neutral	0.54	medium_impact	-0.92	medium_impact	0.49	medium_impact	0.59	0.9	10.33	30.3	0.38	N	0.30	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6918	6918	C	A	MI.4045	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1015	339	L	I	Ctc/Atc	-1.03	0	0	benign	0.34	neutral	0.08	neutral	2.5	neutral	-2.4	neutral	-0.94	low_impact	1.9	0.52	damaging	0.59	neutral	2.42	18.94	deleterious	0.33	0.55	0.49	neutral	0.75	disease	0.41	neutral	0.21	neutral	6	0.91	neutral	0.37	neutral	-6	neutral	0.41	neutral	-0.49	medium_impact	-0.4	medium_impact	0.66	medium_impact	0.81	0.9	3.9	51.21	0.46	N	0.21	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6918	6918	C	G	MI.4046	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1015	339	L	V	Ctc/Gtc	-1.03	0	0	benign	0.34	deleterious	0	neutral	2.51	neutral	-2.38	neutral	-1.41	medium_impact	3	0.52	damaging	0.49	neutral	1.77	14.81	neutral	0.35	0.55	0.45	neutral	0.72	disease	0.45	neutral	0.21	neutral	6	1	deleterious	0.33	neutral	1	deleterious	0.37	neutral	-0.49	medium_impact	-1.48	low_impact	1.67	medium_impact	0.81	0.9	3.9	51.21	0.42	N	0.49	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6918	6918	C	T	MI.4047	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1015	339	L	F	Ctc/Ttc	-1.03	0	0	benign	0.04	deleterious	0	neutral	2.49	deleterious	-3.35	neutral	-1.82	medium_impact	2.89	0.42	damaging	0.58	neutral	2.07	16.64	deleterious	0.38	0.55	0.63	disease	0.85	disease	0.58	disease	0.57	disease	1	1	deleterious	0.48	deleterious	1	deleterious	0.28	neutral	0.54	medium_impact	-1.48	low_impact	1.57	medium_impact	0.77	0.9	3.9	51.21	0.51	N	0.82	polymorphism	0.96	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6919	6919	T	G	MI.4048	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1016	339	L	R	cTc/cGc	-1.26	0	0	possibly_damaging	0.86	deleterious	0	neutral	2.52	deleterious	-4.47	deleterious	-3.16	high_impact	4.49	0.56	damaging	0.35	neutral	4.18	23.80	deleterious	0.09	0.55	0.75	disease	0.95	disease	0.76	disease	0.83	disease	7	1	deleterious	0.07	neutral	5	deleterious	0.81	deleterious	-1.5	low_impact	-1.48	low_impact	3.05	high_impact	0.75	0.9	3.9	51.21	0.52	N	0.91	polymorphism	0.89	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6919	6919	T	C	MI.4049	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1016	339	L	P	cTc/cCc	-1.26	0	0	probably_damaging	0.93	deleterious	0	neutral	2.45	neutral	-2.35	deleterious	-3.76	high_impact	4.49	0.48	damaging	0.4	neutral	3.92	23.50	deleterious	0.11	0.55	0.81	disease	0.93	disease	0.76	disease	0.75	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.86	deleterious	-1.81	low_impact	-1.48	low_impact	3.05	high_impact	0.66	0.9	3.9	51.21	0.56	P	0.81	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8714	8714	C	G	MI.405	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	188	63	T	S	aCt/aGt	-4.5	0	0	benign	0.07	neutral	0.76	neutral	3.98	neutral	1.07	neutral	-1.04	neutral_impact	0.16	0.87	neutral	0.82	neutral	-0.49	0.24	neutral	0.67	0.75	0.33	neutral	0.22	neutral	0.14	neutral	0.42	neutral	2	0.15	neutral	0.85	deleterious	-6	neutral	0.12	neutral	0.31	medium_impact	0.57	medium_impact	-0.96	medium_impact	0.80	0.9	18.58	14.48	0.36	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6919	6919	T	A	MI.4050	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1016	339	L	H	cTc/cAc	-1.26	0	0	probably_damaging	0.95	deleterious	0	neutral	2.45	deleterious	-4.84	deleterious	-3.59	high_impact	4.13	0.57	damaging	0.42	neutral	4.20	23.90	deleterious	0.14	0.55	0.81	disease	0.89	disease	0.67	disease	0.7	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-1.96	low_impact	-1.48	low_impact	2.71	high_impact	0.65	0.9	3.9	51.21	0.35	N	0.70	polymorphism	0.94	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6921	6921	T	C	MI.4051	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1018	340	W	R	Tga/Cga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.74	deleterious	-3.63	deleterious	-8.77	high_impact	5.14	0.57	damaging	0.08	damaging	3.65	23.20	deleterious	0.22	0.55	0.85	disease	0.96	disease	0.83	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.33	0.9	3.51	6.73	0.61	P	0.98	disease_causing	0.96	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6921	6921	T	G	MI.4052	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1018	340	W	G	Tga/Gga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.23	deleterious	-8.14	high_impact	5.14	0.52	damaging	0.11	damaging	3.97	23.60	deleterious	0.19	0.55	0.86	disease	0.92	disease	0.79	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.31	0.9	3.51	6.73	0.6	P	0.89	disease_causing	0.98	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6922	6922	G	C	MI.4053	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1019	340	W	S	tGa/tCa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.77	neutral	-2.56	deleterious	-8.76	high_impact	4.45	0.66	neutral	0.1	damaging	4.10	23.70	deleterious	0.21	0.55	0.78	disease	0.94	disease	0.77	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.28	0.9	3.51	6.73	0.56	P	0.89	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6922	6922	G	T	MI.4054	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1019	340	W	L	tGa/tTa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.87	neutral	-0.97	deleterious	-8.14	high_impact	3.86	0.61	neutral	0.08	damaging	4.36	24.10	deleterious	0.18	0.55	0.47	neutral	0.93	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.47	high_impact	0.27	0.9	3.51	6.73	0.55	P	0.95	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6923	6923	A	C	MI.4055	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1020	340	W	C	tgA/tgC	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.86	deleterious	-8.14	high_impact	5.14	0.56	damaging	0.07	damaging	4.11	23.70	deleterious	0.24	0.55	0.9	disease	0.95	disease	0.8	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.36	0.9	3.51	6.73	0.65	P	0.88	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6923	6923	A	T	MI.4056	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1020	340	W	C	tgA/tgT	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.86	deleterious	-8.14	high_impact	5.14	0.56	damaging	0.07	damaging	4.22	23.90	deleterious	0.24	0.55	0.9	disease	0.95	disease	0.8	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.36	0.9	3.51	6.73	0.65	P	0.88	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6924	6924	G	T	MI.4057	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1021	341	A	S	Gcc/Tcc	1.75	1	0	probably_damaging	1	neutral	0.34	neutral	2.64	neutral	-1.4	neutral	-0.34	neutral_impact	0.1	0.59	damaging	0.32	neutral	2.06	16.61	deleterious	0.33	0.55	0.32	neutral	0.32	neutral	0.25	neutral	0.45	neutral	1	1	deleterious	0.17	neutral	-2	neutral	0.71	deleterious	-3.58	low_impact	0.03	medium_impact	-1.01	low_impact	0.84	0.9	2.34	7.65	0.49	N	0.64	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6924	6924	G	A	MI.4058	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1021	341	A	T	Gcc/Acc	1.75	1	0	probably_damaging	1	neutral	0.1	neutral	2.68	neutral	-0.99	neutral	-0.87	low_impact	1.61	0.56	damaging	0.17	damaging	2.75	21.10	deleterious	0.32	0.55	0.52	disease	0.66	disease	0.3	neutral	0.25	neutral	5	1	deleterious	0.05	neutral	-2	neutral	0.77	deleterious	-3.58	low_impact	-0.34	medium_impact	0.39	medium_impact	0.80	0.9	2.34	7.65	0.52	P	0.20	disease_causing	1	0.03	.	.	.	.	.	.	COSM1138393	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6924	6924	G	C	MI.4059	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1021	341	A	P	Gcc/Ccc	1.75	1	0	probably_damaging	1	deleterious	0.01	neutral	2.55	deleterious	-4.32	neutral	-2.06	high_impact	4	0.52	damaging	0.12	damaging	3.87	23.50	deleterious	0.1	0.55	0.74	disease	0.94	disease	0.66	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-0.92	medium_impact	2.59	high_impact	0.81	0.9	2.34	7.65	0.39	N	0.85	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8714	8714	C	T	MI.406	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	188	63	T	I	aCt/aTt	-4.5	0	0	benign	0.17	neutral	0.5	neutral	3.85	deleterious	-3.21	neutral	-1.43	neutral_impact	0.58	0.86	neutral	0.97	neutral	-0.05	2.14	deleterious	0.52	0.65	0.69	disease	0.44	neutral	0.2	neutral	0.61	disease	2	0.4	neutral	0.67	deleterious	-6	neutral	0.23	neutral	-0.1	medium_impact	0.29	medium_impact	-0.6	medium_impact	0.51	0.9	18.58	14.48	0.37	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6925	6925	C	A	MI.4060	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1022	341	A	D	gCc/gAc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.83	neutral	-2.19	high_impact	4.35	0.56	damaging	0.13	damaging	4.65	24.50	deleterious	0.11	0.55	0.66	disease	0.93	disease	0.67	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.92	high_impact	0.66	0.9	2.34	7.65	0.49	N	0.89	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6925	6925	C	G	MI.4061	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1022	341	A	G	gCc/gGc	9.15	1	0	probably_damaging	0.99	neutral	0.06	neutral	2.56	deleterious	-3.47	neutral	-1.67	medium_impact	3.03	0.58	damaging	0.16	damaging	2.47	19.30	deleterious	0.19	0.55	0.65	disease	0.8	disease	0.5	neutral	0.49	neutral	0	1	deleterious	0.04	neutral	1	deleterious	0.79	deleterious	-2.64	low_impact	-0.47	medium_impact	1.7	medium_impact	0.81	0.9	2.34	7.65	0.51	P	0.56	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6925	6925	C	T	MI.4062	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1022	341	A	V	gCc/gTc	9.15	1	0	probably_damaging	1	neutral	0.33	neutral	2.76	neutral	-0.31	neutral	-1.55	low_impact	1.5	0.61	neutral	0.17	damaging	1.47	13.16	neutral	0.29	0.55	0.37	neutral	0.75	disease	0.3	neutral	0.24	neutral	5	1	deleterious	0.17	neutral	-2	neutral	0.74	deleterious	-3.58	low_impact	0.02	medium_impact	0.29	medium_impact	0.75	0.9	2.34	7.65	0.54	P	0.75	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6927	6927	C	G	MI.4063	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1024	342	L	V	Cta/Gta	-6.81	0	0	probably_damaging	0.99	neutral	0.07	neutral	2.64	neutral	-1.21	neutral	-1.34	medium_impact	2.23	0.53	damaging	0.12	damaging	1.81	15.07	deleterious	0.31	0.55	0.27	neutral	0.59	disease	0.33	neutral	0.32	neutral	4	1	deleterious	0.04	neutral	1	deleterious	0.70	deleterious	-2.64	low_impact	-0.43	medium_impact	0.96	medium_impact	0.78	0.9	2.34	7.81	0.33	N	0.66	polymorphism	0.96	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6927	6927	C	A	MI.4064	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1024	342	L	M	Cta/Ata	-6.81	0	0	probably_damaging	1	neutral	0.18	neutral	2.53	neutral	-2.74	neutral	-0.84	low_impact	1.5	0.59	damaging	0.23	damaging	2.66	20.50	deleterious	0.24	0.55	0.36	neutral	0.46	neutral	0.33	neutral	0.43	neutral	1	1	deleterious	0.09	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.17	medium_impact	0.29	medium_impact	0.66	0.9	2.34	7.81	0.41	N	0.59	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6928	6928	T	A	MI.4065	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1025	342	L	Q	cTa/cAa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-3.96	deleterious	-3.32	high_impact	4.36	0.62	neutral	0.08	damaging	4.11	23.70	deleterious	0.13	0.55	0.71	disease	0.85	disease	0.56	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.93	high_impact	0.76	0.9	2.34	7.81	0.36	N	0.82	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6928	6928	T	G	MI.4066	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1025	342	L	R	cTa/cGa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-4.42	deleterious	-3.39	high_impact	4.36	0.61	neutral	0.06	damaging	4.21	23.90	deleterious	0.1	0.55	0.69	disease	0.94	disease	0.68	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.93	high_impact	0.74	0.9	2.34	7.81	0.37	N	0.90	polymorphism	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6928	6928	T	C	MI.4067	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1025	342	L	P	cTa/cCa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.67	deleterious	-3.9	high_impact	4.7	0.57	damaging	0.07	damaging	3.97	23.60	deleterious	0.1	0.55	0.76	disease	0.92	disease	0.69	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.59	0.9	2.34	7.81	0.47	N	0.83	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6930	6930	G	C	MI.4068	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1027	343	G	R	Gga/Cga	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.03	deleterious	-4.97	high_impact	5.24	0.6	damaging	0.08	damaging	3.96	23.60	deleterious	0.1	0.55	0.46	neutral	0.94	disease	0.8	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.71	0.9	3.31	7.47	0.64	P	0.95	disease_causing	0.77	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6930	6930	G	T	MI.4069	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1027	343	G	W	Gga/Tga	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-5.39	deleterious	-4.96	high_impact	5.24	0.61	neutral	0.09	damaging	4.47	24.20	deleterious	0.1	0.55	0.89	disease	0.94	disease	0.74	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.46	0.9	3.31	7.47	0.59	P	0.83	disease_causing	0.85	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8716	8716	A	C	MI.407	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	190	64	K	Q	Aaa/Caa	-6.35	0	0	probably_damaging	1	neutral	0.4	neutral	4.17	neutral	-1.33	neutral	-2.12	low_impact	1.29	0.91	neutral	0.65	neutral	2.10	16.82	deleterious	0.55	0.65	0.41	neutral	0.64	disease	0.33	neutral	0.48	neutral	0	1	deleterious	0.2	neutral	-2	neutral	0.72	deleterious	-3.6	low_impact	0.19	medium_impact	0.01	medium_impact	0.75	0.9	18.14	20.1	0.31	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6931	6931	G	T	MI.4070	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1028	343	G	V	gGa/gTa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-1.63	deleterious	-5.59	high_impact	4.89	0.58	damaging	0.09	damaging	3.84	23.40	deleterious	0.11	0.55	0.55	disease	0.92	disease	0.7	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.42	high_impact	0.56	0.9	3.31	7.47	0.67	P	0.93	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6931	6931	G	C	MI.4071	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1028	343	G	A	gGa/gCa	9.15	1	0	probably_damaging	1	neutral	0.06	neutral	2.61	neutral	-1.32	deleterious	-3.72	high_impact	4	0.75	neutral	0.13	damaging	3.18	22.70	deleterious	0.23	0.55	0.25	neutral	0.82	disease	0.6	disease	0.56	disease	1	1	deleterious	0.03	neutral	2	deleterious	0.76	deleterious	-3.58	low_impact	-0.47	medium_impact	2.59	high_impact	0.68	0.9	3.31	7.47	0.51	P	0.64	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6931	6931	G	A	MI.4072	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1028	343	G	E	gGa/gAa	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.21	deleterious	-4.96	high_impact	5.24	0.56	damaging	0.09	damaging	4.01	23.60	deleterious	0.13	0.55	0.36	neutral	0.92	disease	0.79	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.74	high_impact	0.64	0.9	3.31	7.47	0.68	P	0.93	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6933	6933	T	C	MI.4073	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1030	344	F	L	Ttc/Ctc	-8.43	0	0	probably_damaging	0.99	deleterious	0	neutral	2.69	neutral	-1.57	deleterious	-3.7	high_impact	4.71	0.74	neutral	0.05	damaging	4.20	23.90	deleterious	0.35	0.55	0.76	disease	0.87	disease	0.63	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.25	high_impact	0.63	0.9	2.14	6.69	0.61	P	0.83	polymorphism	0.82	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6933	6933	T	A	MI.4074	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1030	344	F	I	Ttc/Atc	-8.43	0	0	probably_damaging	1	deleterious	0	neutral	2.66	neutral	-2.57	deleterious	-3.7	high_impact	4.46	0.74	neutral	0.08	damaging	4.51	24.30	deleterious	0.22	0.55	0.81	disease	0.9	disease	0.69	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.62	0.9	2.14	6.69	0.41	N	0.88	polymorphism	0.83	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6933	6933	T	G	MI.4075	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1030	344	F	V	Ttc/Gtc	-8.43	0	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-2.25	deleterious	-4.32	high_impact	4.57	0.72	neutral	0.06	damaging	4.23	23.90	deleterious	0.23	0.55	0.75	disease	0.91	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.63	0.9	2.14	6.69	0.44	N	0.84	polymorphism	0.7	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6934	6934	T	A	MI.4076	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1031	344	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.99	deleterious	0.01	neutral	2.65	deleterious	-3.82	neutral	-1.85	high_impact	5.26	0.69	neutral	0.07	damaging	4.49	24.30	deleterious	0.25	0.55	0.8	disease	0.86	disease	0.66	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.64	low_impact	-0.92	medium_impact	3.76	high_impact	0.65	0.9	2.14	6.69	0.76	P	0.59	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6934	6934	T	C	MI.4077	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1031	344	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-2.82	deleterious	-4.93	high_impact	4.22	0.75	neutral	0.08	damaging	4.40	24.10	deleterious	0.18	0.55	0.35	neutral	0.88	disease	0.67	disease	0.6	disease	2	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.8	high_impact	0.65	0.9	2.14	6.69	0.5	N	0.84	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6934	6934	T	G	MI.4078	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1031	344	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-4.58	deleterious	-4.94	high_impact	4.36	0.72	neutral	0.05	damaging	4.21	23.90	deleterious	0.19	0.55	0.89	disease	0.91	disease	0.72	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.93	high_impact	0.40	0.9	2.14	6.69	0.48	N	0.91	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6935	6935	C	A	MI.4079	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1032	344	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.69	neutral	-1.57	deleterious	-3.7	high_impact	4.71	0.74	neutral	0.05	damaging	4.78	24.70	deleterious	0.35	0.55	0.76	disease	0.87	disease	0.63	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.25	high_impact	0.63	0.9	2.14	6.69	0.7	P	0.83	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8716	8716	A	G	MI.408	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	190	64	K	E	Aaa/Gaa	-6.35	0	0	probably_damaging	0.99	neutral	0.74	neutral	4.2	neutral	-0.19	neutral	-2.19	low_impact	0.98	0.88	neutral	0.28	damaging	2.51	19.53	deleterious	0.37	0.65	0.35	neutral	0.78	disease	0.43	neutral	0.53	disease	1	0.99	deleterious	0.38	neutral	-2	neutral	0.75	deleterious	-2.65	low_impact	0.55	medium_impact	-0.26	medium_impact	0.67	0.9	18.14	20.1	0.19	N	0.91	polymorphism	1	0.03	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6935	6935	C	G	MI.4080	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1032	344	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.69	neutral	-1.57	deleterious	-3.7	high_impact	4.71	0.74	neutral	0.05	damaging	4.45	24.20	deleterious	0.35	0.55	0.76	disease	0.87	disease	0.63	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.25	high_impact	0.63	0.9	2.14	6.69	0.7	P	0.83	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6936	6936	A	G	MI.4081	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1033	345	I	V	Atc/Gtc	-5.66	0	0	probably_damaging	0.92	neutral	0.26	neutral	2.67	neutral	-0.08	neutral	-0.09	neutral_impact	0.76	0.68	neutral	0.71	neutral	-0.77	0.05	neutral	0.53	0.6	0.27	neutral	0.12	neutral	0.37	neutral	0.29	neutral	4	0.93	neutral	0.17	neutral	-2	neutral	0.56	deleterious	-1.76	low_impact	-0.06	medium_impact	-0.4	medium_impact	0.70	0.9	3.7	6.94	0.47	N	0.23	polymorphism	0.65	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6936	6936	A	T	MI.4082	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1033	345	I	F	Atc/Ttc	-5.66	0	0	probably_damaging	1	deleterious	0.01	neutral	2.54	neutral	-2.5	neutral	-2.41	high_impact	4.16	0.6	neutral	0.39	neutral	3.62	23.20	deleterious	0.3	0.55	0.56	disease	0.88	disease	0.64	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-0.92	medium_impact	2.74	high_impact	0.81	0.9	3.7	6.94	0.37	N	0.85	disease_causing	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6936	6936	A	C	MI.4083	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1033	345	I	L	Atc/Ctc	-5.66	0	0	probably_damaging	0.97	neutral	0.12	neutral	2.75	neutral	-0.17	neutral	-1.16	low_impact	1.5	0.65	neutral	0.55	neutral	1.98	16.06	deleterious	0.31	0.55	0.21	neutral	0.65	disease	0.34	neutral	0.24	neutral	5	0.99	deleterious	0.08	neutral	-2	neutral	0.60	deleterious	-2.18	low_impact	-0.29	medium_impact	0.29	medium_impact	0.76	0.9	3.7	6.94	0.44	N	0.61	disease_causing	0.55	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6937	6937	T	A	MI.4084	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1034	345	I	N	aTc/aAc	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.12	deleterious	-3.99	high_impact	4.01	0.61	neutral	0.43	neutral	4.47	24.20	deleterious	0.22	0.55	0.73	disease	0.91	disease	0.65	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.6	high_impact	0.79	0.9	3.7	6.94	0.5	P	0.94	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6937	6937	T	G	MI.4085	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1034	345	I	S	aTc/aGc	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.56	neutral	-2.33	deleterious	-3.38	high_impact	4.16	0.67	neutral	0.5	neutral	4.27	23.90	deleterious	0.2	0.55	0.57	disease	0.88	disease	0.64	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.74	high_impact	0.65	0.9	3.7	6.94	0.5	P	0.62	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6937	6937	T	C	MI.4086	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1034	345	I	T	aTc/aCc	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.58	neutral	-2.6	deleterious	-2.51	high_impact	4.71	0.61	neutral	0.4	neutral	3.20	22.70	deleterious	0.4	0.55	0.52	disease	0.73	disease	0.63	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	3.25	high_impact	0.78	0.9	3.7	6.94	0.68	P	0.76	disease_causing	1	0.36	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6938	6938	C	A	MI.4087	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1035	345	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.55	neutral	-1.38	neutral	-1.48	medium_impact	3.42	0.66	neutral	0.53	neutral	3.81	23.40	deleterious	0.38	0.55	0.47	neutral	0.71	disease	0.53	disease	0.59	disease	2	1	deleterious	0	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-1.48	low_impact	2.06	high_impact	0.83	0.9	3.7	6.94	0.5	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6938	6938	C	G	MI.4088	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1035	345	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.55	neutral	-1.38	neutral	-1.48	medium_impact	3.42	0.66	neutral	0.53	neutral	3.37	22.90	deleterious	0.38	0.55	0.47	neutral	0.71	disease	0.53	disease	0.59	disease	2	1	deleterious	0	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-1.48	low_impact	2.06	high_impact	0.83	0.9	3.7	6.94	0.5	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6939	6939	T	C	MI.4089	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1036	346	F	L	Ttt/Ctt	-3.11	0	0	probably_damaging	0.98	deleterious	0.02	neutral	2.8	neutral	-0.02	deleterious	-3.58	medium_impact	2.84	0.74	neutral	0.06	damaging	4.10	23.70	deleterious	0.34	0.55	0.25	neutral	0.86	disease	0.45	neutral	0.37	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-2.35	low_impact	-0.75	medium_impact	1.52	medium_impact	0.66	0.9	3.9	6.99	0.26	N	0.83	polymorphism	0.86	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8717	8717	A	T	MI.409	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	191	64	K	M	aAa/aTa	0.82	0	0	probably_damaging	1	neutral	0.09	neutral	4.09	deleterious	-3.67	deleterious	-3.58	medium_impact	2.13	0.86	neutral	0.21	damaging	3.80	23.40	deleterious	0.26	0.65	0.82	disease	0.64	disease	0.38	neutral	0.56	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.28	medium_impact	0.73	medium_impact	0.47	0.9	18.14	20.1	0.34	N	0.81	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6939	6939	T	G	MI.4090	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1036	346	F	V	Ttt/Gtt	-3.11	0	0	probably_damaging	1	deleterious	0.03	neutral	2.89	neutral	0.54	deleterious	-4.17	medium_impact	2.33	0.72	neutral	0.07	damaging	4.06	23.70	deleterious	0.25	0.55	0.27	neutral	0.9	disease	0.46	neutral	0.37	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.65	medium_impact	1.05	medium_impact	0.64	0.9	3.9	6.99	0.25	N	0.84	polymorphism	0.76	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6939	6939	T	A	MI.4091	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1036	346	F	I	Ttt/Att	-3.11	0	0	probably_damaging	0.99	neutral	0.07	neutral	2.84	neutral	0.25	deleterious	-3.58	medium_impact	2.58	0.73	neutral	0.08	damaging	4.44	24.20	deleterious	0.15	0.55	0.29	neutral	0.87	disease	0.44	neutral	0.38	neutral	2	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-2.64	low_impact	-0.43	medium_impact	1.28	medium_impact	0.64	0.9	3.9	6.99	0.27	N	0.88	polymorphism	0.87	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6940	6940	T	C	MI.4092	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1037	346	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-2.43	deleterious	-4.8	medium_impact	3.39	0.76	neutral	0.08	damaging	4.27	24.00	deleterious	0.22	0.55	0.42	neutral	0.89	disease	0.62	disease	0.7	disease	4	1	deleterious	0	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.03	high_impact	0.68	0.9	3.9	6.99	0.44	N	0.84	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6940	6940	T	G	MI.4093	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1037	346	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-3.32	deleterious	-4.8	high_impact	3.77	0.74	neutral	0.06	damaging	4.19	23.80	deleterious	0.19	0.55	0.47	neutral	0.93	disease	0.59	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.38	high_impact	0.42	0.9	3.9	6.99	0.42	N	0.91	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6940	6940	T	A	MI.4094	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1037	346	F	Y	tTt/tAt	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.62	neutral	-2.93	neutral	-1.67	high_impact	3.92	0.73	neutral	0.07	damaging	4.30	24.00	deleterious	0.24	0.55	0.56	disease	0.87	disease	0.57	disease	0.59	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.35	low_impact	-1.48	low_impact	2.52	high_impact	0.65	0.9	3.9	6.99	0.51	N	0.59	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6941	6941	T	A	MI.4095	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1038	346	F	L	ttT/ttA	5.91	1	0.01	probably_damaging	0.98	deleterious	0.02	neutral	2.8	neutral	-0.02	deleterious	-3.58	medium_impact	2.84	0.74	neutral	0.06	damaging	4.61	24.40	deleterious	0.34	0.55	0.25	neutral	0.86	disease	0.45	neutral	0.37	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-2.35	low_impact	-0.75	medium_impact	1.52	medium_impact	0.66	0.9	3.9	6.99	0.51	P	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6941	6941	T	G	MI.4096	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1038	346	F	L	ttT/ttG	5.91	1	0.01	probably_damaging	0.98	deleterious	0.02	neutral	2.8	neutral	-0.02	deleterious	-3.58	medium_impact	2.84	0.74	neutral	0.06	damaging	4.47	24.20	deleterious	0.34	0.55	0.25	neutral	0.86	disease	0.45	neutral	0.37	neutral	3	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-2.35	low_impact	-0.75	medium_impact	1.52	medium_impact	0.66	0.9	3.9	6.99	0.5	P	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6942	6942	C	A	MI.4097	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1039	347	L	I	Ctt/Att	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-1.95	neutral	-1.22	high_impact	4.15	0.49	damaging	0.13	damaging	4.23	23.90	deleterious	0.35	0.55	0.26	neutral	0.81	disease	0.52	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.73	high_impact	0.75	0.9	2.34	6.78	0.4	N	0.54	polymorphism	0.96	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6942	6942	C	T	MI.4098	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1039	347	L	F	Ctt/Ttt	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.47	neutral	-2.54	neutral	-2.44	high_impact	3.73	0.41	damaging	0.09	damaging	4.02	23.60	deleterious	0.39	0.55	0.58	disease	0.85	disease	0.54	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.35	high_impact	0.68	0.9	2.34	6.78	0.44	N	0.87	polymorphism	0.7	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6942	6942	C	G	MI.4099	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1039	347	L	V	Ctt/Gtt	-0.1	0	0	probably_damaging	0.99	deleterious	0	neutral	2.52	neutral	-1.85	neutral	-1.84	high_impact	4.32	0.47	damaging	0.11	damaging	3.52	23.10	deleterious	0.36	0.55	0.38	neutral	0.78	disease	0.53	disease	0.55	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.64	low_impact	-1.48	low_impact	2.89	high_impact	0.74	0.9	2.34	6.78	0.41	N	0.66	polymorphism	0.92	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8544	8544	C	A	MI.41	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	18	6	F	L	ttC/ttA	5.91	1	0	probably_damaging	0.92	deleterious	0.01	neutral	4.01	neutral	-0.1	deleterious	-5.08	medium_impact	3.32	0.56	damaging	0.6	neutral	7.51	34.00	deleterious	0.46	0.65	0.61	disease	0.63	disease	0.75	disease	0.75	disease	5	1	deleterious	0.05	neutral	5	deleterious	0.73	deleterious	-1.76	low_impact	-0.84	medium_impact	1.75	medium_impact	0.33	0.9	39.82	8.43	0.58	P	0.89	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8717	8717	A	C	MI.410	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	191	64	K	T	aAa/aCa	0.82	0	0	probably_damaging	0.99	neutral	0.39	neutral	4.18	neutral	-1.88	deleterious	-3.21	low_impact	1.47	0.89	neutral	0.3	neutral	2.36	18.56	deleterious	0.36	0.65	0.39	neutral	0.62	disease	0.34	neutral	0.46	neutral	1	0.99	deleterious	0.2	neutral	-2	neutral	0.72	deleterious	-2.65	low_impact	0.18	medium_impact	0.16	medium_impact	0.46	0.9	18.14	20.1	0.33	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6943	6943	T	C	MI.4100	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1040	347	L	P	cTt/cCt	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.41	deleterious	-4.98	deleterious	-4.29	high_impact	4.57	0.42	damaging	0.11	damaging	3.77	23.40	deleterious	0.13	0.55	0.76	disease	0.89	disease	0.72	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.68	0.9	2.34	6.78	0.47	N	0.83	disease_causing	0.96	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6943	6943	T	A	MI.4101	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1040	347	L	H	cTt/cAt	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.16	deleterious	-4.29	high_impact	5.12	0.53	damaging	0.09	damaging	4.04	23.70	deleterious	0.15	0.55	0.75	disease	0.9	disease	0.69	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.68	0.9	2.34	6.78	0.63	P	0.83	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6943	6943	T	G	MI.4102	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1040	347	L	R	cTt/cGt	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.35	deleterious	-3.67	high_impact	5.12	0.49	damaging	0.1	damaging	4.05	23.70	deleterious	0.11	0.55	0.68	disease	0.95	disease	0.72	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.68	0.9	2.34	6.78	0.61	P	0.90	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6945	6945	T	C	MI.4103	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1042	348	F	L	Ttc/Ctc	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.14	deleterious	-3.84	deleterious	-3.67	high_impact	4.55	0.68	neutral	0.15	damaging	4.11	23.70	deleterious	0.33	0.55	0.77	disease	0.89	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.59	0.9	NA	NA	0.45	N	0.83	polymorphism	0.74	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6945	6945	T	G	MI.4104	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1042	348	F	V	Ttc/Gtc	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.08	deleterious	-5.4	deleterious	-4.28	high_impact	5.25	0.65	neutral	0.16	damaging	4.15	23.80	deleterious	0.23	0.55	0.85	disease	0.93	disease	0.75	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.75	high_impact	0.53	0.9	NA	NA	0.66	P	0.84	polymorphism	0.59	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6945	6945	T	A	MI.4105	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1042	348	F	I	Ttc/Atc	-7.51	0	0	probably_damaging	1	deleterious	0	neutral	2.07	deleterious	-5.51	deleterious	-3.67	high_impact	3.93	0.72	neutral	0.19	damaging	4.50	24.30	deleterious	0.17	0.55	0.86	disease	0.9	disease	0.74	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.53	high_impact	0.59	0.9	NA	NA	0.3	N	0.88	polymorphism	0.76	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6946	6946	T	G	MI.4106	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1043	348	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.05	deleterious	-7.31	deleterious	-4.89	high_impact	4.9	0.7	neutral	0.16	damaging	4.16	23.80	deleterious	0.22	0.55	0.96	disease	0.93	disease	0.75	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.43	high_impact	0.35	0.9	NA	NA	0.65	P	0.91	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6946	6946	T	A	MI.4107	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1043	348	F	Y	tTc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.33	neutral	-2.13	neutral	-1.83	high_impact	4.9	0.71	neutral	0.16	damaging	4.25	23.90	deleterious	0.2	0.55	0.69	disease	0.89	disease	0.69	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.43	high_impact	0.64	0.9	NA	NA	0.75	P	0.59	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6946	6946	T	C	MI.4108	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1043	348	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.08	deleterious	-5.18	deleterious	-4.89	high_impact	4.01	0.66	neutral	0.22	damaging	4.35	24.10	deleterious	0.23	0.55	0.88	disease	0.9	disease	0.73	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.6	high_impact	0.49	0.9	NA	NA	0.52	P	0.84	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6947	6947	C	A	MI.4109	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1044	348	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.14	deleterious	-3.84	deleterious	-3.67	high_impact	4.55	0.68	neutral	0.15	damaging	4.70	24.60	deleterious	0.33	0.55	0.77	disease	0.89	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.59	0.9	NA	NA	0.58	P	0.83	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8718	8718	A	T	MI.411	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	192	64	K	N	aaA/aaT	0.13	0	0	probably_damaging	1	neutral	0.52	neutral	4.17	neutral	-1.84	neutral	-2.35	low_impact	1.09	0.81	neutral	0.33	neutral	2.63	20.40	deleterious	0.66	0.7	0.34	neutral	0.53	disease	0.31	neutral	0.46	neutral	1	0.99	deleterious	0.26	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.31	medium_impact	-0.16	medium_impact	0.62	0.9	18.14	20.1	0.23	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6947	6947	C	G	MI.4110	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1044	348	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.14	deleterious	-3.84	deleterious	-3.67	high_impact	4.55	0.68	neutral	0.15	damaging	4.42	24.20	deleterious	0.33	0.55	0.77	disease	0.89	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.59	0.9	NA	NA	0.57	P	0.83	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6948	6948	A	T	MI.4111	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1045	349	T	S	Acc/Tcc	-0.8	0.06	0	probably_damaging	0.99	deleterious	0.01	neutral	2.66	neutral	-1.91	neutral	-2.41	medium_impact	2.75	0.71	neutral	0.11	damaging	3.35	22.90	deleterious	0.33	0.55	0.52	disease	0.81	disease	0.59	disease	0.38	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-2.64	low_impact	-0.92	medium_impact	1.44	medium_impact	0.56	0.9	3.31	6.76	0.27	N	0.79	disease_causing	0.83	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6948	6948	A	G	MI.4112	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1045	349	T	A	Acc/Gcc	-0.8	0.06	0	probably_damaging	0.99	deleterious	0.01	neutral	2.7	neutral	-1.04	deleterious	-3.03	high_impact	4.42	0.74	neutral	0.07	damaging	3.58	23.20	deleterious	0.45	0.55	0.42	neutral	0.83	disease	0.61	disease	0.55	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-0.92	medium_impact	2.98	high_impact	0.46	0.9	3.31	6.76	0.38	N	0.69	disease_causing	0.93	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6948	6948	A	C	MI.4113	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1045	349	T	P	Acc/Ccc	-0.8	0.06	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-3.91	deleterious	-3.65	high_impact	4.77	0.59	damaging	0.09	damaging	3.56	23.10	deleterious	0.16	0.55	0.29	neutral	0.92	disease	0.74	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.31	high_impact	0.52	0.9	3.31	6.76	0.64	P	0.92	disease_causing	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6949	6949	C	A	MI.4114	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1046	349	T	N	aCc/aAc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-2.68	deleterious	-3.03	high_impact	4.42	0.66	neutral	0.06	damaging	3.75	23.30	deleterious	0.35	0.55	0.68	disease	0.92	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.67	0.9	3.31	6.76	0.5	N	0.80	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6949	6949	C	T	MI.4115	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1046	349	T	I	aCc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-0.14	deleterious	-3.65	high_impact	3.87	0.71	neutral	0.05	damaging	4.07	23.70	deleterious	0.31	0.55	0.3	neutral	0.94	disease	0.67	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.47	high_impact	0.64	0.9	3.31	6.76	0.45	N	0.92	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6949	6949	C	G	MI.4116	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1046	349	T	S	aCc/aGc	8.69	1	0	probably_damaging	0.99	deleterious	0.01	neutral	2.66	neutral	-1.91	neutral	-2.41	medium_impact	2.75	0.71	neutral	0.11	damaging	3.57	23.10	deleterious	0.33	0.55	0.52	disease	0.81	disease	0.59	disease	0.38	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-2.64	low_impact	-0.92	medium_impact	1.44	medium_impact	0.56	0.9	3.31	6.76	0.41	N	0.79	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6951	6951	G	A	MI.4117	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1048	350	V	M	Gta/Ata	-7.28	0	0	benign	0.12	neutral	0.13	neutral	2.71	neutral	-1.08	neutral	-0.48	neutral_impact	0.42	0.67	neutral	0.66	neutral	0.63	8.36	deleterious	0.38	0.55	0.5	neutral	0.51	disease	0.36	neutral	0.4	neutral	2	0.85	neutral	0.51	deleterious	-6	neutral	0.21	neutral	0.06	medium_impact	-0.27	medium_impact	-0.71	medium_impact	0.91	0.95	12.09	24.13	0.41	N	0.75	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6951	6951	G	T	MI.4118	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1048	350	V	L	Gta/Tta	-7.28	0	0	benign	0.02	neutral	0.23	neutral	2.86	neutral	0.43	neutral	-0.41	neutral_impact	0.41	0.64	neutral	0.64	neutral	0.50	7.46	deleterious	0.32	0.55	0.27	neutral	0.62	disease	0.33	neutral	0.38	neutral	2	0.76	neutral	0.61	deleterious	-6	neutral	0.18	neutral	0.83	medium_impact	-0.1	medium_impact	-0.72	medium_impact	0.66	0.9	12.09	24.13	0.43	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6951	6951	G	C	MI.4119	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1048	350	V	L	Gta/Cta	-7.28	0	0	benign	0.02	neutral	0.23	neutral	2.86	neutral	0.43	neutral	-0.41	neutral_impact	0.41	0.64	neutral	0.64	neutral	0.40	6.58	deleterious	0.32	0.55	0.27	neutral	0.62	disease	0.33	neutral	0.38	neutral	2	0.76	neutral	0.61	deleterious	-6	neutral	0.18	neutral	0.83	medium_impact	-0.1	medium_impact	-0.72	medium_impact	0.66	0.9	12.09	24.13	0.42	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8718	8718	A	C	MI.412	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	192	64	K	N	aaA/aaC	0.13	0	0	probably_damaging	1	neutral	0.52	neutral	4.17	neutral	-1.84	neutral	-2.35	low_impact	1.09	0.81	neutral	0.33	neutral	2.53	19.65	deleterious	0.66	0.7	0.34	neutral	0.53	disease	0.31	neutral	0.46	neutral	1	0.99	deleterious	0.26	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.31	medium_impact	-0.16	medium_impact	0.62	0.9	18.14	20.1	0.23	N	0.88	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6952	6952	T	A	MI.4120	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1049	350	V	E	gTa/gAa	0.82	0.54	0	possibly_damaging	0.66	deleterious	0	neutral	2.64	deleterious	-3.36	deleterious	-3.01	high_impact	3.98	0.63	neutral	0.43	neutral	4.49	24.30	deleterious	0.09	0.55	0.84	disease	0.92	disease	0.75	disease	0.76	disease	5	1	deleterious	0.17	neutral	5	deleterious	0.72	deleterious	-1.03	low_impact	-1.48	low_impact	2.58	high_impact	0.41	0.9	12.09	24.13	0.36	N	0.92	polymorphism	0.85	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6952	6952	T	G	MI.4121	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1049	350	V	G	gTa/gGa	0.82	0.54	0	possibly_damaging	0.81	deleterious	0	neutral	2.79	neutral	-0.13	deleterious	-3.59	medium_impact	3.28	0.69	neutral	0.59	neutral	3.72	23.30	deleterious	0.14	0.55	0.83	disease	0.83	disease	0.64	disease	0.74	disease	5	1	deleterious	0.1	neutral	4	deleterious	0.74	deleterious	-1.35	low_impact	-1.48	low_impact	1.93	medium_impact	0.42	0.9	12.09	24.13	0.3	N	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6952	6952	T	C	MI.4122	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1049	350	V	A	gTa/gCa	0.82	0.54	0	possibly_damaging	0.44	deleterious	0	neutral	2.73	neutral	-0.88	neutral	-1.89	medium_impact	3.08	0.69	neutral	0.67	neutral	2.03	16.40	deleterious	0.28	0.55	0.49	neutral	0.68	disease	0.61	disease	0.69	disease	4	1	deleterious	0.28	neutral	4	deleterious	0.37	neutral	-0.66	medium_impact	-1.48	low_impact	1.75	medium_impact	0.63	0.9	12.09	24.13	0.35	N	0.67	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6954	6954	G	T	MI.4123	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1051	351	G	C	Ggt/Tgt	-11.44	0	0	probably_damaging	1	deleterious	0	neutral	2.01	deleterious	-6.75	deleterious	-5.47	high_impact	5.26	0.45	damaging	0.16	damaging	4.19	23.80	deleterious	0.12	0.55	0.9	disease	0.96	disease	0.78	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.46	0.9	1.56	6.79	0.54	P	0.98	disease_causing	0.56	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6954	6954	G	A	MI.4124	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1051	351	G	S	Ggt/Agt	-11.44	0	0	probably_damaging	1	deleterious	0	neutral	2.16	deleterious	-3	deleterious	-3.64	high_impact	4.92	0.45	damaging	0.24	damaging	4.24	23.90	deleterious	0.18	0.55	0.67	disease	0.91	disease	0.77	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.54	0.9	1.56	6.79	0.7	P	0.73	polymorphism	0.76	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6954	6954	G	C	MI.4125	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1051	351	G	R	Ggt/Cgt	-11.44	0	0	probably_damaging	1	deleterious	0	neutral	2	deleterious	-7.54	deleterious	-4.87	high_impact	4.92	0.49	damaging	0.15	damaging	4.01	23.60	deleterious	0.11	0.55	0.9	disease	0.96	disease	0.84	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.63	0.9	1.56	6.79	0.56	P	0.95	polymorphism	0.6	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6955	6955	G	A	MI.4126	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1052	351	G	D	gGt/gAt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2	deleterious	-7.1	deleterious	-4.26	high_impact	5.26	0.44	damaging	0.17	damaging	3.87	23.50	deleterious	0.14	0.55	0.9	disease	0.94	disease	0.84	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.38	0.9	1.56	6.79	0.83	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	COSM1155666	.	.	G6955A	Mild EXIT and MR	+	+	Reported	1	.	P	P	damaging
chrM	6955	6955	G	T	MI.4127	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1052	351	G	V	gGt/gTt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.02	deleterious	-5.77	deleterious	-5.47	high_impact	5.26	0.46	damaging	0.19	damaging	3.88	23.50	deleterious	0.11	0.55	0.38	neutral	0.95	disease	0.79	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.44	0.9	1.56	6.79	0.62	P	0.93	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6955	6955	G	C	MI.4128	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1052	351	G	A	gGt/gCt	9.15	1	0	probably_damaging	1	deleterious	0	neutral	2.42	neutral	-1.55	deleterious	-3.65	high_impact	4.71	0.62	neutral	0.33	neutral	3.20	22.70	deleterious	0.17	0.55	0.5	disease	0.86	disease	0.74	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.25	high_impact	0.58	0.9	1.56	6.79	0.71	P	0.64	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6957	6957	G	A	MI.4129	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1054	352	G	S	Ggc/Agc	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	1.44	deleterious	-3.84	deleterious	-3.65	high_impact	4.92	0.48	damaging	0.02	damaging	4.26	23.90	deleterious	0.19	0.55	0.37	neutral	0.91	disease	0.73	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.60	0.9	2.14	6.72	0.61	P	0.73	disease_causing	0.53	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8719	8719	G	T	MI.413	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	193	65	G	W	Gga/Tga	-1.26	0	0	probably_damaging	1	neutral	0.07	neutral	4.28	deleterious	-6.63	deleterious	-7.23	high_impact	4.09	0.63	neutral	0.25	damaging	4.33	24.00	deleterious	0.25	0.65	0.8	disease	0.88	disease	0.68	disease	0.73	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.34	medium_impact	2.41	high_impact	0.39	0.9	49.12	8.59	0.33	N	0.99	disease_causing	0.97	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6957	6957	G	T	MI.4130	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1054	352	G	C	Ggc/Tgc	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	1.3	deleterious	-6.28	deleterious	-5.48	high_impact	5.26	0.4	damaging	0.01	damaging	4.30	24.00	deleterious	0.12	0.55	0.92	disease	0.95	disease	0.75	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.47	0.9	2.14	6.72	0.52	P	0.98	disease_causing	0.82	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6957	6957	G	C	MI.4131	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1054	352	G	R	Ggc/Cgc	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	1.27	deleterious	-8.17	deleterious	-4.87	high_impact	4.92	0.45	damaging	0.02	damaging	4.07	23.70	deleterious	0.13	0.55	0.92	disease	0.95	disease	0.83	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.54	0.9	2.14	6.72	0.52	P	0.95	disease_causing	0.7	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6958	6958	G	A	MI.4132	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1055	352	G	D	gGc/gAc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	1.27	deleterious	-8.25	deleterious	-4.26	high_impact	5.26	0.33	damaging	0.01	damaging	3.91	23.50	deleterious	0.11	0.55	0.88	disease	0.93	disease	0.82	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.38	0.9	2.14	6.72	0.72	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6958	6958	G	T	MI.4133	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1055	352	G	V	gGc/gTc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	1.28	deleterious	-7.16	deleterious	-5.48	high_impact	5.26	0.47	damaging	0.02	damaging	3.86	23.50	deleterious	0.13	0.55	0.87	disease	0.94	disease	0.76	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.51	0.9	2.14	6.72	0.62	P	0.93	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6958	6958	G	C	MI.4134	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1055	352	G	A	gGc/gCc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	1.33	deleterious	-5.31	deleterious	-3.65	high_impact	5.26	0.57	damaging	0.03	damaging	3.15	22.60	deleterious	0.18	0.55	0.66	disease	0.84	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.67	0.9	2.14	6.72	0.71	P	0.64	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6960	6960	C	G	MI.4135	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1057	353	L	V	Ctg/Gtg	-20	0	0.01	probably_damaging	0.99	neutral	0.06	neutral	2.78	neutral	-0.13	neutral	-1.39	medium_impact	2.3	0.41	damaging	0.47	neutral	3.52	23.10	deleterious	0.44	0.55	0.25	neutral	0.56	disease	0.4	neutral	0.2	neutral	6	1	deleterious	0.04	neutral	1	deleterious	0.71	deleterious	-2.64	low_impact	-0.47	medium_impact	1.03	medium_impact	0.75	0.9	3.12	6.69	0.57	P	0.66	polymorphism	0.96	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6960	6960	C	A	MI.4136	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1057	353	L	M	Ctg/Atg	-20	0	0.01	probably_damaging	1	deleterious	0.03	neutral	2.54	neutral	-2.44	neutral	-0.98	medium_impact	3.21	0.49	damaging	0.66	neutral	3.77	23.40	deleterious	0.32	0.55	0.52	disease	0.67	disease	0.54	disease	0.49	neutral	0	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-3.58	low_impact	-0.65	medium_impact	1.87	medium_impact	0.80	0.9	3.12	6.69	0.45	N	0.59	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6961	6961	T	G	MI.4137	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1058	353	L	R	cTg/cGg	-0.1	0.01	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-4.37	deleterious	-3.46	high_impact	5.03	0.45	damaging	0.32	neutral	4.27	23.90	deleterious	0.17	0.55	0.72	disease	0.94	disease	0.77	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.55	high_impact	0.56	0.9	3.12	6.69	0.69	P	0.90	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6961	6961	T	A	MI.4138	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1058	353	L	Q	cTg/cAg	-0.1	0.01	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.55	deleterious	-3.42	high_impact	5.03	0.45	damaging	0.41	neutral	4.28	24.00	deleterious	0.18	0.55	0.74	disease	0.88	disease	0.67	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.55	high_impact	0.75	0.9	3.12	6.69	0.67	P	0.82	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6961	6961	T	C	MI.4139	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1058	353	L	P	cTg/cCg	-0.1	0.01	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.92	deleterious	-3.97	high_impact	4.48	0.3	damaging	0.36	neutral	3.95	23.60	deleterious	0.18	0.55	0.79	disease	0.9	disease	0.76	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.04	high_impact	0.64	0.9	3.12	6.69	0.72	P	0.83	disease_causing	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8719	8719	G	C	MI.414	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	193	65	G	R	Gga/Cga	-1.26	0	0	probably_damaging	1	neutral	0.13	neutral	4.37	deleterious	-3.81	deleterious	-7.17	medium_impact	3.06	0.59	damaging	0.25	damaging	3.86	23.50	deleterious	0.26	0.65	0.7	disease	0.89	disease	0.67	disease	0.74	disease	5	1	deleterious	0.07	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	-0.18	medium_impact	1.53	medium_impact	0.65	0.9	49.12	8.59	0.28	N	0.98	disease_causing	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6963	6963	A	G	MI.4140	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1060	354	T	A	Act/Gct	-1.95	0	0	probably_damaging	0.99	deleterious	0	neutral	2.49	neutral	-2.59	deleterious	-3.02	high_impact	5.22	0.72	neutral	0.06	damaging	3.58	23.20	deleterious	0.47	0.55	0.67	disease	0.78	disease	0.71	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	3.72	high_impact	0.49	0.9	2.34	7.35	0.67	P	0.69	polymorphism	0.93	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6963	6963	A	C	MI.4141	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1060	354	T	P	Act/Cct	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-4.25	deleterious	-3.63	high_impact	5.22	0.57	damaging	0.08	damaging	3.56	23.10	deleterious	0.19	0.55	0.89	disease	0.9	disease	0.82	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.57	0.9	2.34	7.35	0.7	P	0.92	polymorphism	0.73	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6963	6963	A	T	MI.4142	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1060	354	T	S	Act/Tct	-1.95	0	0	probably_damaging	0.99	deleterious	0.04	neutral	2.55	neutral	-1.59	neutral	-2.41	medium_impact	2.79	0.69	neutral	0.07	damaging	3.39	23.00	deleterious	0.39	0.55	0.55	disease	0.8	disease	0.55	disease	0.45	neutral	1	1	deleterious	0.03	neutral	5	deleterious	0.79	deleterious	-2.64	low_impact	-0.58	medium_impact	1.48	medium_impact	0.70	0.9	2.34	7.35	0.24	N	0.79	polymorphism	0.98	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6964	6964	C	A	MI.4143	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1061	354	T	N	aCt/aAt	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.45	deleterious	-3.6	deleterious	-3.02	high_impact	5.22	0.63	neutral	0.04	damaging	3.64	23.20	deleterious	0.42	0.55	0.88	disease	0.89	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.72	high_impact	0.85	0.9	2.34	7.35	0.74	P	0.80	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6964	6964	C	G	MI.4144	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1061	354	T	S	aCt/aGt	6.84	1	0	probably_damaging	0.99	deleterious	0.04	neutral	2.55	neutral	-1.59	neutral	-2.41	medium_impact	2.79	0.69	neutral	0.07	damaging	3.59	23.20	deleterious	0.39	0.55	0.55	disease	0.8	disease	0.55	disease	0.45	neutral	1	1	deleterious	0.03	neutral	5	deleterious	0.79	deleterious	-2.64	low_impact	-0.58	medium_impact	1.48	medium_impact	0.70	0.9	2.34	7.35	0.43	N	0.79	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6964	6964	C	T	MI.4145	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1061	354	T	I	aCt/aTt	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.23	deleterious	-3.62	high_impact	4.53	0.69	neutral	0.04	damaging	4.03	23.70	deleterious	0.42	0.55	0.92	disease	0.92	disease	0.74	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.08	high_impact	0.63	0.9	2.34	7.35	0.53	P	0.92	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6966	6966	G	A	MI.4146	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1063	355	G	S	Ggc/Agc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	0	deleterious	-9.49	deleterious	-3.63	high_impact	4.92	0.63	neutral	0.25	damaging	4.25	23.90	deleterious	0.23	0.55	0.81	disease	0.88	disease	0.73	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.73	0.9	2.92	6.68	0.67	P	0.73	polymorphism	0.73	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6966	6966	G	T	MI.4147	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1063	355	G	C	Ggc/Tgc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	-0.02	deleterious	-12.37	deleterious	-5.44	high_impact	5.26	0.52	damaging	0.18	damaging	4.22	23.90	deleterious	0.12	0.55	0.96	disease	0.93	disease	0.72	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.68	0.9	2.92	6.68	0.45	N	0.98	disease_causing	0.61	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6966	6966	G	C	MI.4148	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1063	355	G	R	Ggc/Cgc	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	-0.01	deleterious	-11.07	deleterious	-4.84	high_impact	4.57	0.56	damaging	0.16	damaging	4.03	23.70	deleterious	0.09	0.55	0.8	disease	0.93	disease	0.82	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.66	0.9	2.92	6.68	0.47	N	0.95	polymorphism	0.56	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6967	6967	G	T	MI.4149	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1064	355	G	V	gGc/gTc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	-0.01	deleterious	-11.11	deleterious	-5.44	high_impact	4.92	0.54	damaging	0.22	damaging	3.85	23.40	deleterious	0.1	0.55	0.91	disease	0.91	disease	0.75	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.59	0.9	2.92	6.68	0.58	P	0.93	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8720	8720	G	A	MI.415	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	194	65	G	E	gGa/gAa	2.44	0.99	0	probably_damaging	1	neutral	0.11	neutral	4.46	deleterious	-3.31	deleterious	-7.17	medium_impact	3.4	0.73	neutral	0.33	neutral	3.84	23.40	deleterious	0.35	0.65	0.57	disease	0.87	disease	0.64	disease	0.73	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.22	medium_impact	1.82	medium_impact	0.38	0.9	49.12	8.59	0.43	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6967	6967	G	C	MI.4150	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1064	355	G	A	gGc/gCc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	0.08	deleterious	-6.65	deleterious	-3.63	high_impact	5.26	0.71	neutral	0.35	neutral	3.17	22.70	deleterious	0.26	0.55	0.8	disease	0.79	disease	0.69	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.63	0.9	2.92	6.68	0.7	P	0.64	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6967	6967	G	A	MI.4151	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1064	355	G	D	gGc/gAc	9.15	1	0	probably_damaging	1	deleterious	0	neutral	-0.01	deleterious	-10.23	deleterious	-4.24	high_impact	5.26	0.49	damaging	0.19	damaging	3.89	23.50	deleterious	0.11	0.55	0.82	disease	0.92	disease	0.81	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.76	high_impact	0.50	0.9	2.92	6.68	0.62	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6969	6969	A	G	MI.4152	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1066	356	I	V	Att/Gtt	-10.28	0	0	benign	0	neutral	0.52	neutral	2.97	neutral	0.04	neutral	0.06	neutral_impact	-0.16	0.69	neutral	0.71	neutral	0.72	8.94	deleterious	0.59	0.65	0.2	neutral	0.09	neutral	0.25	neutral	0.26	neutral	5	0.47	neutral	0.76	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.21	medium_impact	-1.25	low_impact	0.74	0.9	3.7	8.4	0.46	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6969	6969	A	C	MI.4153	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1066	356	I	L	Att/Ctt	-10.28	0	0	benign	0.08	deleterious	0.03	neutral	2.75	neutral	-0.67	neutral	-1.15	medium_impact	2.39	0.64	neutral	0.59	neutral	2.84	21.60	deleterious	0.41	0.55	0.26	neutral	0.74	disease	0.34	neutral	0.44	neutral	1	0.97	neutral	0.48	deleterious	1	deleterious	0.21	neutral	0.24	medium_impact	-0.65	medium_impact	1.11	medium_impact	0.77	0.9	3.7	8.4	0.46	N	0.61	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6969	6969	A	T	MI.4154	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1066	356	I	F	Att/Ttt	-10.28	0	0	possibly_damaging	0.58	deleterious	0	neutral	2.72	deleterious	-3.39	neutral	-2.37	high_impact	4.11	0.6	neutral	0.41	neutral	3.94	23.50	deleterious	0.29	0.55	0.59	disease	0.88	disease	0.61	disease	0.74	disease	5	1	deleterious	0.21	neutral	5	deleterious	0.69	deleterious	-0.89	medium_impact	-1.48	low_impact	2.7	high_impact	0.79	0.9	3.7	8.4	0.37	N	0.85	polymorphism	0.63	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6970	6970	T	C	MI.4155	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1067	356	I	T	aTt/aCt	8.69	1	0	possibly_damaging	0.56	deleterious	0	neutral	2.64	deleterious	-3.51	neutral	-2.31	high_impact	3.9	0.65	neutral	0.44	neutral	3.47	23.00	deleterious	0.4	0.55	0.54	disease	0.75	disease	0.55	disease	0.67	disease	3	1	deleterious	0.22	neutral	5	deleterious	0.53	deleterious	-0.86	medium_impact	-1.48	low_impact	2.5	high_impact	0.69	0.9	3.7	8.4	0.53	P	0.76	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6970	6970	T	A	MI.4156	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1067	356	I	N	aTt/aAt	8.69	1	0	probably_damaging	0.95	deleterious	0	neutral	2.59	deleterious	-4.97	deleterious	-3.84	high_impact	4.45	0.62	neutral	0.44	neutral	4.46	24.20	deleterious	0.2	0.55	0.77	disease	0.91	disease	0.6	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.84	deleterious	-1.96	low_impact	-1.48	low_impact	3.01	high_impact	0.58	0.9	3.7	8.4	0.5	P	0.94	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6970	6970	T	G	MI.4157	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1067	356	I	S	aTt/aGt	8.69	1	0	possibly_damaging	0.81	deleterious	0	neutral	2.66	deleterious	-4	deleterious	-3.24	high_impact	4.11	0.67	neutral	0.51	neutral	4.37	24.10	deleterious	0.2	0.55	0.62	disease	0.9	disease	0.58	disease	0.73	disease	5	1	deleterious	0.1	neutral	5	deleterious	0.73	deleterious	-1.35	low_impact	-1.48	low_impact	2.7	high_impact	0.53	0.9	3.7	8.4	0.53	P	0.62	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6971	6971	T	A	MI.4158	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1068	356	I	M	atT/atA	7.53	1	0	possibly_damaging	0.81	deleterious	0	neutral	2.66	neutral	-2.65	neutral	-1.43	high_impact	3.56	0.67	neutral	0.6	neutral	3.81	23.40	deleterious	0.36	0.55	0.42	neutral	0.73	disease	0.49	neutral	0.53	disease	1	1	deleterious	0.1	neutral	5	deleterious	0.60	deleterious	-1.35	low_impact	-1.48	low_impact	2.19	high_impact	0.83	0.9	3.7	8.4	0.54	P	0.76	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6971	6971	T	G	MI.4159	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1068	356	I	M	atT/atG	7.53	1	0	possibly_damaging	0.81	deleterious	0	neutral	2.66	neutral	-2.65	neutral	-1.43	high_impact	3.56	0.67	neutral	0.6	neutral	3.47	23.00	deleterious	0.36	0.55	0.42	neutral	0.73	disease	0.49	neutral	0.53	disease	1	1	deleterious	0.1	neutral	5	deleterious	0.60	deleterious	-1.35	low_impact	-1.48	low_impact	2.19	high_impact	0.83	0.9	3.7	8.4	0.53	P	0.76	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8720	8720	G	T	MI.416	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	194	65	G	V	gGa/gTa	2.44	0.99	0	probably_damaging	1	neutral	0.2	neutral	4.33	deleterious	-3.53	deleterious	-8.05	medium_impact	3.2	0.59	damaging	0.32	neutral	3.68	23.30	deleterious	0.33	0.65	0.73	disease	0.86	disease	0.6	disease	0.71	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	-0.05	medium_impact	1.65	medium_impact	0.45	0.9	49.12	8.59	0.42	N	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6972	6972	G	A	MI.4160	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1069	357	V	M	Gta/Ata	-3.34	0	0	possibly_damaging	0.82	neutral	0.21	neutral	2.88	neutral	0.68	neutral	-1.08	low_impact	1.32	0.66	neutral	0.6	neutral	2.25	17.85	deleterious	0.47	0.55	0.25	neutral	0.65	disease	0.33	neutral	0.45	neutral	1	0.89	neutral	0.2	neutral	-3	neutral	0.64	deleterious	-1.38	low_impact	-0.13	medium_impact	0.12	medium_impact	0.97	1	12.09	28.1	0.43	N	0.74	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6972	6972	G	T	MI.4161	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1069	357	V	L	Gta/Tta	-3.34	0	0	benign	0.03	neutral	0.06	neutral	3	neutral	1.37	neutral	-1.03	medium_impact	2.47	0.65	neutral	0.57	neutral	1.77	14.83	neutral	0.37	0.55	0.29	neutral	0.78	disease	0.37	neutral	0.56	disease	1	0.94	neutral	0.52	deleterious	-3	neutral	0.23	neutral	0.66	medium_impact	-0.47	medium_impact	1.18	medium_impact	0.77	0.9	12.09	28.1	0.46	N	0.49	disease_causing	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6972	6972	G	C	MI.4162	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1069	357	V	L	Gta/Cta	-3.34	0	0	benign	0.03	neutral	0.06	neutral	3	neutral	1.37	neutral	-1.03	medium_impact	2.47	0.65	neutral	0.57	neutral	1.62	13.95	neutral	0.37	0.55	0.29	neutral	0.78	disease	0.37	neutral	0.56	disease	1	0.94	neutral	0.52	deleterious	-3	neutral	0.23	neutral	0.66	medium_impact	-0.47	medium_impact	1.18	medium_impact	0.77	0.9	12.09	28.1	0.46	N	0.49	disease_causing	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6973	6973	T	C	MI.4163	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1070	357	V	A	gTa/gCa	3.6	1	0	possibly_damaging	0.54	deleterious	0	neutral	2.78	neutral	-0.33	neutral	-2.18	medium_impact	3	0.65	neutral	0.62	neutral	1.95	15.92	deleterious	0.29	0.55	0.39	neutral	0.67	disease	0.42	neutral	0.49	neutral	0	1	deleterious	0.23	neutral	4	deleterious	0.52	deleterious	-0.82	medium_impact	-1.48	low_impact	1.67	medium_impact	0.64	0.9	12.09	28.1	0.48	N	0.66	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6973	6973	T	A	MI.4164	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1070	357	V	E	gTa/gAa	3.6	1	0	possibly_damaging	0.86	deleterious	0	neutral	2.69	neutral	-2.98	deleterious	-3.31	high_impact	4.28	0.6	neutral	0.5	neutral	4.48	24.20	deleterious	0.09	0.55	0.69	disease	0.93	disease	0.72	disease	0.81	disease	6	1	deleterious	0.07	neutral	5	deleterious	0.87	deleterious	-1.5	low_impact	-1.48	low_impact	2.85	high_impact	0.61	0.9	12.09	28.1	0.54	P	0.92	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6973	6973	T	G	MI.4165	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1070	357	V	G	gTa/gGa	3.6	1	0	possibly_damaging	0.9	deleterious	0	neutral	2.69	neutral	-2.75	deleterious	-3.9	high_impact	4.28	0.61	neutral	0.61	neutral	3.69	23.30	deleterious	0.13	0.55	0.66	disease	0.85	disease	0.6	disease	0.73	disease	5	1	deleterious	0.05	neutral	5	deleterious	0.80	deleterious	-1.65	low_impact	-1.48	low_impact	2.85	high_impact	0.49	0.9	12.09	28.1	0.48	N	0.75	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6975	6975	T	A	MI.4166	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1072	358	L	M	Tta/Ata	-13.29	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-3.47	neutral	-1.17	high_impact	4.68	0.56	damaging	0.07	damaging	3.63	23.20	deleterious	0.32	0.55	0.67	disease	0.71	disease	0.61	disease	0.57	disease	1	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.81	0.9	1.56	6.7	0.47	N	0.59	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6975	6975	T	G	MI.4167	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1072	358	L	V	Tta/Gta	-13.29	0	0	probably_damaging	0.99	deleterious	0	neutral	2.61	neutral	-2.75	neutral	-1.74	high_impact	4.13	0.5	damaging	0.07	damaging	3.48	23.10	deleterious	0.34	0.55	0.42	neutral	0.74	disease	0.62	disease	0.58	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.64	low_impact	-1.48	low_impact	2.71	high_impact	0.66	0.9	1.56	6.7	0.31	N	0.66	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6976	6976	T	C	MI.4168	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1073	358	L	S	tTa/tCa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-3.37	deleterious	-3.55	high_impact	4.68	0.51	damaging	0.08	damaging	3.88	23.50	deleterious	0.24	0.55	0.62	disease	0.88	disease	0.68	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.63	0.9	1.56	6.7	0.5	N	0.73	polymorphism	1	0.45	.	.	.	.	.	.	COSM1331632	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6976	6976	T	G	MI.4169	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1073	358	L	W	tTa/tGa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-6.4	deleterious	-3.56	high_impact	4.88	0.47	damaging	0.05	damaging	3.87	23.50	deleterious	0.11	0.55	0.89	disease	0.83	disease	0.66	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.41	high_impact	0.55	0.9	1.56	6.7	0.56	P	0.92	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8720	8720	G	C	MI.417	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	194	65	G	A	gGa/gCa	2.44	0.99	0	probably_damaging	1	neutral	0.26	neutral	4.36	neutral	-2.39	deleterious	-5.29	medium_impact	2.15	0.66	neutral	0.41	neutral	2.90	21.80	deleterious	0.3	0.65	0.64	disease	0.65	disease	0.36	neutral	0.48	neutral	0	1	deleterious	0.13	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	0.04	medium_impact	0.75	medium_impact	0.57	0.9	49.12	8.59	0.43	N	0.79	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6977	6977	A	T	MI.4170	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1074	358	L	F	ttA/ttT	5.91	0.9	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.97	neutral	-2.37	high_impact	4.88	0.49	damaging	0.04	damaging	3.66	23.20	deleterious	0.34	0.55	0.68	disease	0.83	disease	0.63	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.41	high_impact	0.66	0.9	1.56	6.7	0.66	P	0.87	polymorphism	0.9	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6977	6977	A	C	MI.4171	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1074	358	L	F	ttA/ttC	5.91	0.9	0	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-3.97	neutral	-2.37	high_impact	4.88	0.49	damaging	0.04	damaging	3.58	23.20	deleterious	0.34	0.55	0.68	disease	0.83	disease	0.63	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.41	high_impact	0.66	0.9	1.56	6.7	0.66	P	0.87	polymorphism	0.9	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6978	6978	G	A	MI.4172	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1075	359	A	T	Gca/Aca	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.57	neutral	-2.52	neutral	-1.55	high_impact	4.37	0.64	neutral	0.19	damaging	4.34	24.00	deleterious	0.43	0.55	0.61	disease	0.79	disease	0.53	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.94	high_impact	0.76	0.9	5.85	39.81	0.36	N	0.38	polymorphism	0.97	0.13	rs28451817	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6978	6978	G	C	MI.4173	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1075	359	A	P	Gca/Cca	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.53	deleterious	-3.28	neutral	-2.31	high_impact	4.37	0.62	neutral	0.11	damaging	3.93	23.50	deleterious	0.12	0.55	0.78	disease	0.91	disease	0.54	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	2.94	high_impact	0.83	0.9	5.85	39.81	0.38	N	0.59	polymorphism	0.9	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6978	6978	G	T	MI.4174	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1075	359	A	S	Gca/Tca	-1.26	0	0	probably_damaging	1	neutral	0.66	neutral	2.79	neutral	-0.85	neutral	-0.54	neutral_impact	0.39	0.63	neutral	0.89	neutral	2.34	18.41	deleterious	0.34	0.55	0.35	neutral	0.34	neutral	0.28	neutral	0.42	neutral	2	1	deleterious	0.33	neutral	-2	neutral	0.75	deleterious	-3.58	low_impact	0.35	medium_impact	-0.74	medium_impact	0.90	0.95	5.85	39.81	0.36	N	0.09	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6979	6979	C	A	MI.4175	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1076	359	A	E	gCa/gAa	4.06	1	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-3.93	neutral	-2.12	high_impact	4.71	0.64	neutral	0.12	damaging	4.62	24.50	deleterious	0.11	0.55	0.29	neutral	0.92	disease	0.72	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.25	high_impact	0.75	0.9	5.85	39.81	0.66	P	0.67	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6979	6979	C	T	MI.4176	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1076	359	A	V	gCa/gTa	4.06	1	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-5.03	neutral	-2.15	high_impact	4.71	0.6	damaging	0.12	damaging	4.51	24.30	deleterious	0.36	0.55	0.73	disease	0.85	disease	0.62	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.25	high_impact	0.76	0.9	5.85	39.81	0.68	P	0.56	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6979	6979	C	G	MI.4177	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1076	359	A	G	gCa/gGa	4.06	1	0	probably_damaging	1	deleterious	0.04	neutral	2.6	neutral	-2.15	neutral	-1.53	medium_impact	2.98	0.64	neutral	0.16	damaging	3.93	23.50	deleterious	0.23	0.55	0.32	neutral	0.76	disease	0.52	disease	0.57	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-3.58	low_impact	-0.58	medium_impact	1.65	medium_impact	0.83	0.9	5.85	39.81	0.42	N	0.34	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6981	6981	A	C	MI.4178	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1078	360	N	H	Aac/Cac	-8.2	0	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	-2.84	deleterious	-2.96	high_impact	4.13	0.58	damaging	0.05	damaging	3.17	22.70	deleterious	0.48	0.55	0.42	neutral	0.88	disease	0.7	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.42	0.9	1.75	7.28	0.32	N	0.83	disease_causing	0.74	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6981	6981	A	G	MI.4179	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1078	360	N	D	Aac/Gac	-8.2	0	0	probably_damaging	0.99	deleterious	0	neutral	2.86	neutral	-1.05	deleterious	-2.96	high_impact	4.3	0.48	damaging	0.07	damaging	3.97	23.60	deleterious	0.54	0.6	0.48	neutral	0.86	disease	0.76	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	2.87	high_impact	0.46	0.9	1.75	7.28	0.46	N	0.92	disease_causing	0.58	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8722	8722	C	T	MI.418	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	196	66	R	W	Cga/Tga	-3.11	0	0	possibly_damaging	0.86	neutral	0.15	neutral	4.28	deleterious	-5.25	deleterious	-3.81	low_impact	1.07	0.87	neutral	0.25	damaging	5.05	25.20	deleterious	0.36	0.65	0.94	disease	0.69	disease	0.64	disease	0.85	disease	7	0.93	neutral	0.15	neutral	-3	neutral	0.76	deleterious	-1.5	low_impact	-0.13	medium_impact	-0.18	medium_impact	0.87	0.9	18.14	13.71	0.33	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6981	6981	A	T	MI.4180	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1078	360	N	Y	Aac/Tac	-8.2	0	0	probably_damaging	1	deleterious	0	neutral	2.86	deleterious	-3.54	deleterious	-4.74	high_impact	5.11	0.54	damaging	0.06	damaging	3.87	23.50	deleterious	0.33	0.55	0.24	neutral	0.92	disease	0.74	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.32	0.9	1.75	7.28	0.58	P	0.93	disease_causing	0.92	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6982	6982	A	G	MI.4181	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1079	360	N	S	aAc/aGc	8.69	1	0	probably_damaging	0.98	neutral	0.07	neutral	2.95	neutral	0.28	deleterious	-2.96	medium_impact	2.44	0.56	damaging	0.07	damaging	3.07	22.40	deleterious	0.49	0.55	0.18	neutral	0.85	disease	0.45	neutral	0.42	neutral	2	1	deleterious	0.05	neutral	1	deleterious	0.76	deleterious	-2.35	low_impact	-0.43	medium_impact	1.15	medium_impact	0.27	0.9	1.75	7.28	0.46	N	0.79	disease_causing	1	0.08	rs201872766	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	6982	6982	A	T	MI.4182	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1079	360	N	I	aAc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.98	neutral	-1.76	deleterious	-5.34	high_impact	4.3	0.59	damaging	0.06	damaging	3.87	23.50	deleterious	0.32	0.55	0.34	neutral	0.93	disease	0.69	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.87	high_impact	0.26	0.9	1.75	7.28	0.48	N	0.98	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6982	6982	A	C	MI.4183	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1079	360	N	T	aAc/aCc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.91	neutral	-1.32	deleterious	-3.56	high_impact	4.07	0.59	damaging	0.07	damaging	3.39	23.00	deleterious	0.47	0.55	0.33	neutral	0.87	disease	0.69	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.66	high_impact	0.43	0.9	1.75	7.28	0.46	N	0.59	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6983	6983	C	A	MI.4184	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1080	360	N	K	aaC/aaA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	-0.85	deleterious	-3.56	high_impact	5.11	0.51	damaging	0.06	damaging	4.54	24.30	deleterious	0.55	0.6	0.35	neutral	0.9	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.47	0.9	1.75	7.28	0.71	P	0.92	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6983	6983	C	G	MI.4185	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1080	360	N	K	aaC/aaG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	-0.85	deleterious	-3.56	high_impact	5.11	0.51	damaging	0.06	damaging	4.14	23.80	deleterious	0.55	0.6	0.35	neutral	0.9	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.47	0.9	1.75	7.28	0.7	P	0.92	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6984	6984	T	C	MI.4186	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1081	361	S	P	Tca/Cca	-1.03	0.01	0	probably_damaging	1	deleterious	0	neutral	2.95	neutral	-0.41	deleterious	-2.88	medium_impact	2.96	0.29	damaging	0.07	damaging	4.16	23.80	deleterious	0.2	0.55	0.49	neutral	0.87	disease	0.56	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	1.63	medium_impact	0.60	0.9	1.56	6.95	0.69	P	0.91	disease_causing	0.99	0.08	.	.	.	.	.	.	COSM1155667	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6984	6984	T	A	MI.4187	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1081	361	S	T	Tca/Aca	-1.03	0.01	0	probably_damaging	0.99	deleterious	0	neutral	2.87	neutral	-0.96	neutral	-1.69	high_impact	4.11	0.47	damaging	0.06	damaging	4.07	23.70	deleterious	0.33	0.55	0.39	neutral	0.69	disease	0.42	neutral	0.49	neutral	0	1	deleterious	0.01	neutral	6	deleterious	0.72	deleterious	-2.64	low_impact	-1.48	low_impact	2.7	high_impact	0.64	0.9	1.56	6.95	0.39	N	0.43	disease_causing	0.94	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6984	6984	T	G	MI.4188	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1081	361	S	A	Tca/Gca	-1.03	0.01	0	probably_damaging	0.99	neutral	0.15	neutral	2.97	neutral	0.58	neutral	-1.66	medium_impact	2.36	0.53	damaging	0.15	damaging	3.83	23.40	deleterious	0.41	0.55	0.22	neutral	0.4	neutral	0.21	neutral	0.39	neutral	2	1	deleterious	0.08	neutral	1	deleterious	0.70	deleterious	-2.64	low_impact	-0.23	medium_impact	1.08	medium_impact	0.59	0.9	1.56	6.95	0.45	N	0.35	disease_causing	0.81	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6985	6985	C	G	MI.4189	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1082	361	S	W	tCa/tGa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.83	deleterious	-3.42	deleterious	-3.98	high_impact	5	0.44	damaging	0.04	damaging	4.49	24.30	deleterious	0.19	0.55	0.83	disease	0.9	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.43	0.9	1.56	6.95	0.7	P	0.94	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8722	8722	C	G	MI.419	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	196	66	R	G	Cga/Gga	-3.11	0	0	benign	0.28	neutral	0.34	neutral	4.38	neutral	-2.38	deleterious	-3.54	neutral_impact	-0.51	0.84	neutral	0.36	neutral	2.31	18.26	deleterious	0.39	0.65	0.32	neutral	0.47	neutral	0.61	disease	0.49	neutral	0	0.59	neutral	0.53	deleterious	-6	neutral	0.40	neutral	-0.37	medium_impact	0.13	medium_impact	-1.54	low_impact	0.46	0.9	18.14	13.71	0.29	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6985	6985	C	T	MI.4190	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1082	361	S	L	tCa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.92	neutral	-0.22	deleterious	-3.38	high_impact	4.2	0.5	damaging	0.03	damaging	4.81	24.80	deleterious	0.23	0.55	0.32	neutral	0.87	disease	0.6	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.78	high_impact	0.79	0.9	1.56	6.95	0.52	P	0.90	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6987	6987	T	A	MI.4191	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1084	362	S	T	Tca/Aca	-13.75	0	0	probably_damaging	0.95	deleterious	0	neutral	2.72	neutral	-0.97	neutral	-1.63	medium_impact	3.46	0.49	damaging	0.17	damaging	3.91	23.50	deleterious	0.26	0.55	0.38	neutral	0.67	disease	0.4	neutral	0.47	neutral	1	1	deleterious	0.03	neutral	5	deleterious	0.74	deleterious	-1.96	low_impact	-1.48	low_impact	2.1	high_impact	0.63	0.9	2.92	6.73	0.41	N	0.43	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6987	6987	T	G	MI.4192	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1084	362	S	A	Tca/Gca	-13.75	0	0	probably_damaging	0.97	deleterious	0.01	neutral	2.79	neutral	-0.45	neutral	-1.67	medium_impact	2.6	0.59	damaging	0.19	damaging	3.81	23.40	deleterious	0.34	0.55	0.19	neutral	0.56	disease	0.26	neutral	0.4	neutral	2	1	deleterious	0.02	neutral	5	deleterious	0.66	deleterious	-2.18	low_impact	-0.92	medium_impact	1.3	medium_impact	0.56	0.9	2.92	6.73	0.36	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6987	6987	T	C	MI.4193	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1084	362	S	P	Tca/Cca	-13.75	0	0	probably_damaging	0.99	deleterious	0	neutral	2.84	neutral	-0.29	deleterious	-2.87	medium_impact	2.5	0.38	damaging	0.22	damaging	4.12	23.80	deleterious	0.16	0.55	0.23	neutral	0.86	disease	0.4	neutral	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.79	deleterious	-2.64	low_impact	-1.48	low_impact	1.21	medium_impact	0.55	0.9	2.92	6.73	0.44	N	0.91	polymorphism	0.93	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6988	6988	C	G	MI.4194	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1085	362	S	W	tCa/tGa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-5.52	deleterious	-4.04	high_impact	5	0.49	damaging	0.15	damaging	4.40	24.10	deleterious	0.18	0.55	0.87	disease	0.9	disease	0.63	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.39	0.9	2.92	6.73	0.67	P	0.94	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6988	6988	C	T	MI.4195	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1085	362	S	L	tCa/tTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-2.16	deleterious	-3.43	high_impact	5	0.5	damaging	0.13	damaging	4.68	24.60	deleterious	0.21	0.55	0.5	neutral	0.88	disease	0.56	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.76	0.9	2.92	6.73	0.7	P	0.90	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6990	6990	C	A	MI.4196	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1087	363	L	M	Cta/Ata	-8.66	0	0	probably_damaging	1	deleterious	0.02	neutral	2.74	neutral	-2.78	neutral	-0.84	medium_impact	3.06	0.58	damaging	0.06	damaging	3.88	23.50	deleterious	0.34	0.55	0.46	neutral	0.5	disease	0.21	neutral	0.47	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.75	medium_impact	1.73	medium_impact	0.86	0.9	2.92	6.66	0.33	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6990	6990	C	G	MI.4197	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1087	363	L	V	Cta/Gta	-8.66	0	0	probably_damaging	0.97	neutral	0.08	neutral	3.09	neutral	0.4	neutral	-0.52	medium_impact	2.02	0.55	damaging	0.08	damaging	2.44	19.07	deleterious	0.35	0.55	0.23	neutral	0.48	neutral	0.21	neutral	0.44	neutral	1	0.99	deleterious	0.06	neutral	1	deleterious	0.70	deleterious	-2.18	low_impact	-0.4	medium_impact	0.77	medium_impact	0.62	0.9	2.92	6.66	0.37	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6991	6991	T	C	MI.4198	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1088	363	L	P	cTa/cCa	-0.57	0	0.01	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-4.17	deleterious	-3.47	high_impact	4.47	0.49	damaging	0.03	damaging	4.07	23.70	deleterious	0.16	0.55	0.31	neutral	0.88	disease	0.56	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.03	high_impact	0.57	0.9	2.92	6.66	0.37	N	0.83	disease_causing	1	0.32	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6991	6991	T	G	MI.4199	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1088	363	L	R	cTa/cGa	-0.57	0	0.01	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-3.69	deleterious	-3.21	high_impact	4.47	0.52	damaging	0.03	damaging	4.32	24.00	deleterious	0.15	0.55	0.67	disease	0.89	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.03	high_impact	0.49	0.9	2.92	6.66	0.41	N	0.90	polymorphism	0.98	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8544	8544	C	G	MI.42	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	18	6	F	L	ttC/ttG	5.91	1	0	probably_damaging	0.92	deleterious	0.01	neutral	4.01	neutral	-0.1	deleterious	-5.08	medium_impact	3.32	0.56	damaging	0.6	neutral	4.30	24.00	deleterious	0.46	0.65	0.61	disease	0.63	disease	0.75	disease	0.75	disease	5	1	deleterious	0.05	neutral	5	deleterious	0.73	deleterious	-1.76	low_impact	-0.84	medium_impact	1.75	medium_impact	0.33	0.9	39.82	8.43	0.59	P	0.89	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8723	8723	G	C	MI.420	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	197	66	R	P	cGa/cCa	1.75	0.01	0.02	possibly_damaging	0.56	neutral	0.31	neutral	4.37	deleterious	-3.16	deleterious	-3.37	neutral_impact	0.52	0.75	neutral	0.27	damaging	3.86	23.50	deleterious	0.27	0.65	0.47	neutral	0.78	disease	0.63	disease	0.73	disease	5	0.69	neutral	0.38	neutral	-3	neutral	0.67	deleterious	-0.86	medium_impact	0.1	medium_impact	-0.65	medium_impact	0.51	0.9	18.14	13.71	0.29	N	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6991	6991	T	A	MI.4200	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1088	363	L	Q	cTa/cAa	-0.57	0	0.01	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-4.09	deleterious	-3.17	high_impact	4.47	0.53	damaging	0.04	damaging	4.47	24.20	deleterious	0.16	0.55	0.69	disease	0.76	disease	0.57	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.03	high_impact	0.71	0.9	2.92	6.66	0.38	N	0.82	polymorphism	0.98	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6993	6993	G	T	MI.4201	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1090	364	D	Y	Gac/Tac	0.13	0.96	0	probably_damaging	0.99	deleterious	0	neutral	2.29	deleterious	-8.09	deleterious	-5.26	high_impact	4.86	0.59	damaging	0.09	damaging	4.02	23.60	deleterious	0.18	0.55	0.94	disease	0.95	disease	0.79	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.93	deleterious	-2.64	low_impact	-1.48	low_impact	3.39	high_impact	0.57	0.9	4.29	7.75	0.59	P	0.94	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6993	6993	G	A	MI.4202	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1090	364	D	N	Gac/Aac	0.13	0.96	0	benign	0.08	deleterious	0	neutral	2.81	neutral	-2.01	deleterious	-2.91	high_impact	3.68	0.44	damaging	0.11	damaging	4.31	24.00	deleterious	0.52	0.6	0.43	neutral	0.85	disease	0.62	disease	0.63	disease	3	1	deleterious	0.46	neutral	2	deleterious	0.32	neutral	0.24	medium_impact	-1.48	low_impact	2.3	high_impact	0.81	0.9	4.29	7.75	0.49	N	0.89	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6993	6993	G	C	MI.4203	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1090	364	D	H	Gac/Cac	0.13	0.96	0	probably_damaging	0.97	deleterious	0	neutral	2.3	deleterious	-6.81	deleterious	-4.08	high_impact	5.21	0.62	neutral	0.08	damaging	3.73	23.30	deleterious	0.25	0.55	0.87	disease	0.9	disease	0.82	disease	0.77	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.90	deleterious	-2.18	low_impact	-1.48	low_impact	3.71	high_impact	0.65	0.9	4.29	7.75	0.64	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6994	6994	A	G	MI.4204	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1091	364	D	G	gAc/gGc	9.15	1	0	possibly_damaging	0.79	deleterious	0	neutral	2.32	deleterious	-5.05	deleterious	-4.09	high_impact	4.51	0.57	damaging	0.11	damaging	4.07	23.70	deleterious	0.24	0.55	0.38	neutral	0.91	disease	0.75	disease	0.74	disease	5	1	deleterious	0.11	neutral	5	deleterious	0.66	deleterious	-1.3	low_impact	-1.48	low_impact	3.07	high_impact	0.63	0.9	4.29	7.75	0.51	P	0.85	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6994	6994	A	C	MI.4205	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1091	364	D	A	gAc/gCc	9.15	1	0	possibly_damaging	0.73	deleterious	0	neutral	2.31	deleterious	-5.75	deleterious	-4.67	high_impact	5.21	0.71	neutral	0.12	damaging	3.79	23.40	deleterious	0.23	0.55	0.77	disease	0.88	disease	0.75	disease	0.75	disease	5	1	deleterious	0.14	neutral	5	deleterious	0.78	deleterious	-1.16	low_impact	-1.48	low_impact	3.71	high_impact	0.62	0.9	4.29	7.75	0.68	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6994	6994	A	T	MI.4206	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1091	364	D	V	gAc/gTc	9.15	1	0	probably_damaging	0.96	deleterious	0	neutral	2.29	deleterious	-7.47	deleterious	-5.26	high_impact	5.21	0.47	damaging	0.11	damaging	3.84	23.40	deleterious	0.18	0.55	0.91	disease	0.95	disease	0.76	disease	0.8	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.90	deleterious	-2.06	low_impact	-1.48	low_impact	3.71	high_impact	0.42	0.9	4.29	7.75	0.62	P	0.93	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6995	6995	C	G	MI.4207	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1092	364	D	E	gaC/gaG	6.84	1	0	benign	0.36	deleterious	0	neutral	2.34	deleterious	-3.88	neutral	-2.33	high_impact	4.66	0.48	damaging	0.12	damaging	4.00	23.60	deleterious	0.45	0.55	0.56	disease	0.88	disease	0.68	disease	0.71	disease	4	1	deleterious	0.32	neutral	2	deleterious	0.52	deleterious	-0.52	medium_impact	-1.48	low_impact	3.2	high_impact	0.67	0.9	4.29	7.75	0.55	P	0.65	disease_causing	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6995	6995	C	A	MI.4208	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1092	364	D	E	gaC/gaA	6.84	1	0	benign	0.36	deleterious	0	neutral	2.34	deleterious	-3.88	neutral	-2.33	high_impact	4.66	0.48	damaging	0.12	damaging	4.33	24.00	deleterious	0.45	0.55	0.56	disease	0.88	disease	0.68	disease	0.71	disease	4	1	deleterious	0.32	neutral	2	deleterious	0.52	deleterious	-0.52	medium_impact	-1.48	low_impact	3.2	high_impact	0.67	0.9	4.29	7.75	0.56	P	0.65	disease_causing	1	0.53	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6996	6996	A	C	MI.4209	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1093	365	I	L	Atc/Ctc	-3.8	0	0	probably_damaging	0.96	neutral	0.07	neutral	2.8	neutral	-0.03	neutral	-1.1	medium_impact	2.1	0.66	neutral	0.13	damaging	3.81	23.40	deleterious	0.4	0.55	0.22	neutral	0.73	disease	0.21	neutral	0.4	neutral	2	0.99	deleterious	0.06	neutral	1	deleterious	0.56	deleterious	-2.06	low_impact	-0.43	medium_impact	0.84	medium_impact	0.77	0.9	5.07	9.12	0.35	N	0.61	disease_causing	0.96	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8723	8723	G	T	MI.421	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	197	66	R	L	cGa/cTa	1.75	0.01	0.02	benign	0.22	neutral	0.57	neutral	4.31	neutral	-2.05	deleterious	-3.61	neutral_impact	-0.33	0.94	neutral	0.69	neutral	2.35	18.47	deleterious	0.36	0.65	0.57	disease	0.63	disease	0.53	disease	0.59	disease	2	0.32	neutral	0.68	deleterious	-6	neutral	0.44	deleterious	-0.23	medium_impact	0.36	medium_impact	-1.38	low_impact	0.57	0.9	18.14	13.71	0.26	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6996	6996	A	T	MI.4210	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1093	365	I	F	Atc/Ttc	-3.8	0	0	probably_damaging	0.99	deleterious	0	neutral	2.72	neutral	-1.03	neutral	-2.22	medium_impact	2.84	0.63	neutral	0.1	damaging	3.76	23.30	deleterious	0.33	0.55	0.4	neutral	0.86	disease	0.56	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-2.64	low_impact	-1.48	low_impact	1.52	medium_impact	0.73	0.9	5.07	9.12	0.26	N	0.85	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6996	6996	A	G	MI.4211	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1093	365	I	V	Atc/Gtc	-3.8	0	0	probably_damaging	0.91	neutral	0.24	neutral	2.85	neutral	0.31	neutral	-0.41	low_impact	1.84	0.72	neutral	0.69	neutral	1.88	15.48	deleterious	0.59	0.65	0.25	neutral	0.31	neutral	0.21	neutral	0.41	neutral	2	0.93	neutral	0.17	neutral	-2	neutral	0.53	deleterious	-1.7	low_impact	-0.09	medium_impact	0.6	medium_impact	0.70	0.9	5.07	9.12	0.49	N	0.23	disease_causing	0.9	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	6997	6997	T	A	MI.4212	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1094	365	I	N	aTc/aAc	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.66	neutral	-2.84	deleterious	-3.77	high_impact	3.93	0.65	neutral	0.13	damaging	4.61	24.40	deleterious	0.22	0.55	0.68	disease	0.87	disease	0.58	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.53	high_impact	0.65	0.9	5.07	9.12	0.43	N	0.94	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6997	6997	T	C	MI.4213	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1094	365	I	T	aTc/aCc	4.76	1	0	probably_damaging	1	deleterious	0.03	neutral	2.75	neutral	-0.61	deleterious	-2.51	medium_impact	2.37	0.64	neutral	0.16	damaging	3.51	23.10	deleterious	0.29	0.55	0.46	neutral	0.75	disease	0.3	neutral	0.44	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-0.65	medium_impact	1.09	medium_impact	0.74	0.9	5.07	9.12	0.42	N	0.76	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6997	6997	T	G	MI.4214	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1094	365	I	S	aTc/aGc	4.76	1	0	probably_damaging	1	neutral	0.07	neutral	2.69	neutral	-1.8	deleterious	-3.2	high_impact	3.67	0.68	neutral	0.16	damaging	4.45	24.20	deleterious	0.26	0.55	0.51	disease	0.9	disease	0.58	disease	0.7	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.85	deleterious	-3.58	low_impact	-0.43	medium_impact	2.29	high_impact	0.59	0.9	5.07	9.12	0.47	N	0.62	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6998	6998	C	A	MI.4215	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1095	365	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.71	neutral	-1.3	neutral	-1.58	medium_impact	3.2	0.66	neutral	0.15	damaging	4.00	23.60	deleterious	0.35	0.55	0.46	neutral	0.64	disease	0.36	neutral	0.42	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	1.86	medium_impact	0.81	0.9	5.07	9.12	0.48	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6998	6998	C	G	MI.4216	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1095	365	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.71	neutral	-1.3	neutral	-1.58	medium_impact	3.2	0.66	neutral	0.15	damaging	3.49	23.10	deleterious	0.35	0.55	0.46	neutral	0.64	disease	0.36	neutral	0.42	neutral	2	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	1.86	medium_impact	0.81	0.9	5.07	9.12	0.48	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6999	6999	G	T	MI.4217	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1096	366	V	L	Gta/Tta	-2.42	0	0	benign	0.07	neutral	0.2	neutral	2.76	neutral	-0.5	neutral	-0.8	low_impact	1.46	0.73	neutral	0.17	damaging	0.81	9.52	deleterious	0.3	0.55	0.27	neutral	0.6	disease	0.27	neutral	0.46	neutral	1	0.78	neutral	0.57	deleterious	-6	neutral	0.18	neutral	0.3	medium_impact	-0.14	medium_impact	0.25	medium_impact	0.72	0.9	8.19	18.05	0.4	N	0.55	polymorphism	0.9	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6999	6999	G	C	MI.4218	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1096	366	V	L	Gta/Cta	-2.42	0	0	benign	0.07	neutral	0.2	neutral	2.76	neutral	-0.5	neutral	-0.8	low_impact	1.46	0.73	neutral	0.17	damaging	0.66	8.53	deleterious	0.3	0.55	0.27	neutral	0.6	disease	0.27	neutral	0.46	neutral	1	0.78	neutral	0.57	deleterious	-6	neutral	0.18	neutral	0.3	medium_impact	-0.14	medium_impact	0.25	medium_impact	0.72	0.9	8.19	18.05	0.4	N	0.55	polymorphism	0.9	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	6999	6999	G	A	MI.4219	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1096	366	V	M	Gta/Ata	-2.42	0	0	benign	0.21	neutral	0.09	neutral	2.7	neutral	-1.35	neutral	-0.94	low_impact	1.48	0.65	neutral	0.27	damaging	0.51	7.48	deleterious	0.29	0.55	0.46	neutral	0.37	neutral	0.25	neutral	0.47	neutral	1	0.9	neutral	0.44	neutral	-6	neutral	0.27	neutral	-0.22	medium_impact	-0.37	medium_impact	0.27	medium_impact	0.73	0.9	8.19	18.05	0.42	N	0.82	polymorphism	0.88	0.03	rs879099364	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8723	8723	G	A	MI.422	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	197	66	R	Q	cGa/cAa	1.75	0.01	0.02	benign	0.01	neutral	0.52	neutral	4.4	neutral	-0.97	neutral	-0.52	neutral_impact	-1.06	0.91	neutral	0.94	neutral	0.79	9.41	deleterious	0.39	0.65	0.31	neutral	0.27	neutral	0.32	neutral	0.43	neutral	1	0.46	neutral	0.76	deleterious	-6	neutral	0.16	neutral	1.14	medium_impact	0.31	medium_impact	-2.01	low_impact	0.81	0.9	18.14	13.71	0.36	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7000	7000	T	A	MI.4220	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1097	366	V	E	gTa/gAa	1.52	0.93	0	possibly_damaging	0.85	deleterious	0	neutral	2.66	neutral	-2.36	deleterious	-2.96	medium_impact	3.28	0.67	neutral	0.18	damaging	4.67	24.50	deleterious	0.1	0.55	0.41	neutral	0.86	disease	0.7	disease	0.75	disease	5	1	deleterious	0.08	neutral	4	deleterious	0.77	deleterious	-1.47	low_impact	-1.48	low_impact	1.93	medium_impact	0.48	0.9	8.19	18.05	0.34	N	0.84	disease_causing	0.95	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7000	7000	T	G	MI.4221	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1097	366	V	G	gTa/gGa	1.52	0.93	0	probably_damaging	0.93	deleterious	0	neutral	2.65	neutral	-2.81	deleterious	-3.48	medium_impact	3.08	0.68	neutral	0.19	damaging	3.90	23.50	deleterious	0.16	0.55	0.42	neutral	0.73	disease	0.6	disease	0.7	disease	4	1	deleterious	0.04	neutral	5	deleterious	0.72	deleterious	-1.81	low_impact	-1.48	low_impact	1.75	medium_impact	0.46	0.9	8.19	18.05	0.33	N	0.71	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7000	7000	T	C	MI.4222	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1097	366	V	A	gTa/gCa	1.52	0.93	0	possibly_damaging	0.7	neutral	0.23	neutral	2.72	neutral	-0.93	neutral	-1.82	low_impact	0.88	0.66	neutral	0.4	neutral	2.01	16.26	deleterious	0.25	0.55	0.21	neutral	0.28	neutral	0.3	neutral	0.44	neutral	1	0.82	neutral	0.27	neutral	-3	neutral	0.47	deleterious	-1.1	low_impact	-0.1	medium_impact	-0.29	medium_impact	0.57	0.9	8.19	18.05	0.44	N	0.47	polymorphism	0.5	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7002	7002	C	A	MI.4223	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1099	367	L	M	Cta/Ata	-12.37	0	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-3.11	neutral	-1.01	medium_impact	2.87	0.49	damaging	0.08	damaging	3.76	23.30	deleterious	0.33	0.55	0.41	neutral	0.55	disease	0.32	neutral	0.21	neutral	6	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	1.55	medium_impact	0.70	0.9	NA	NA	0.34	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7002	7002	C	G	MI.4224	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1099	367	L	V	Cta/Gta	-12.37	0	0	probably_damaging	0.98	deleterious	0	neutral	2.79	neutral	-0.32	neutral	-1.65	medium_impact	3.12	0.5	damaging	0.04	damaging	3.52	23.10	deleterious	0.28	0.55	0.19	neutral	0.67	disease	0.63	disease	0.56	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-2.35	low_impact	-1.48	low_impact	1.78	medium_impact	0.56	0.9	NA	NA	0.31	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7003	7003	T	C	MI.4225	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1100	367	L	P	cTa/cCa	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.84	deleterious	-3.91	high_impact	4.29	0.36	damaging	0.05	damaging	4.07	23.70	deleterious	0.1	0.55	0.76	disease	0.83	disease	0.65	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	2.86	high_impact	0.63	0.9	NA	NA	0.45	N	0.83	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7003	7003	T	G	MI.4226	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1100	367	L	R	cTa/cGa	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.26	deleterious	-3.34	high_impact	5.09	0.48	damaging	0.03	damaging	4.27	24.00	deleterious	0.09	0.55	0.69	disease	0.89	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.6	high_impact	0.45	0.9	NA	NA	0.66	P	0.90	disease_causing	0.89	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7003	7003	T	A	MI.4227	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1100	367	L	Q	cTa/cAa	0.36	0.02	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-3.95	deleterious	-3.31	high_impact	5.09	0.51	damaging	0.03	damaging	4.34	24.10	deleterious	0.11	0.55	0.71	disease	0.84	disease	0.64	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.6	high_impact	0.64	0.9	NA	NA	0.62	P	0.82	disease_causing	0.87	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7005	7005	C	A	MI.4228	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1102	368	H	N	Cac/Aac	-10.05	0	0	probably_damaging	1	deleterious	0	neutral	2.14	deleterious	-4.36	deleterious	-3.84	high_impact	4.61	0.55	damaging	0.04	damaging	4.03	23.60	deleterious	0.39	0.55	0.69	disease	0.87	disease	0.81	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.16	high_impact	0.57	0.9	3.51	7.83	0.5	N	0.86	polymorphism	0.97	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7005	7005	C	G	MI.4229	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1102	368	H	D	Cac/Gac	-10.05	0	0	probably_damaging	1	deleterious	0	neutral	2.13	deleterious	-4.63	deleterious	-4.94	high_impact	4.46	0.5	damaging	0.03	damaging	3.99	23.60	deleterious	0.23	0.55	0.7	disease	0.89	disease	0.86	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.45	0.9	3.51	7.83	0.49	N	0.97	polymorphism	0.9	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8725	8725	A	C	MI.423	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	199	67	T	P	Acc/Ccc	-1.03	0	0.01	possibly_damaging	0.56	neutral	0.32	neutral	4.35	neutral	-0.73	deleterious	-2.92	neutral_impact	0.22	0.87	neutral	0.41	neutral	3.11	22.50	deleterious	0.28	0.65	0.46	neutral	0.87	disease	0.24	neutral	0.52	disease	0	0.68	neutral	0.38	neutral	-3	neutral	0.69	deleterious	-0.86	medium_impact	0.11	medium_impact	-0.91	medium_impact	0.64	0.9	13.27	10.97	0.3	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7005	7005	C	T	MI.4230	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1102	368	H	Y	Cac/Tac	-10.05	0	0	probably_damaging	1	deleterious	0	neutral	2.09	deleterious	-6.14	deleterious	-3.29	high_impact	5.16	0.56	damaging	0.03	damaging	3.83	23.40	deleterious	0.36	0.55	0.34	neutral	0.9	disease	0.81	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.39	0.9	3.51	7.83	0.61	P	0.72	polymorphism	0.96	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7006	7006	A	G	MI.4231	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1103	368	H	R	cAc/cGc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.14	deleterious	-4.16	deleterious	-4.38	high_impact	4.82	0.58	damaging	0.04	damaging	3.02	22.30	deleterious	0.39	0.55	0.67	disease	0.89	disease	0.83	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.45	0.9	3.51	7.83	0.73	P	0.85	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7006	7006	A	C	MI.4232	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1103	368	H	P	cAc/cCc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.1	deleterious	-5.48	deleterious	-5.49	high_impact	4.82	0.49	damaging	0.04	damaging	3.31	22.90	deleterious	0.25	0.55	0.81	disease	0.89	disease	0.78	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.34	0.9	3.51	7.83	0.65	P	0.90	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7006	7006	A	T	MI.4233	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1103	368	H	L	cAc/cTc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.11	deleterious	-5.21	deleterious	-6.03	high_impact	5.16	0.66	neutral	0.03	damaging	3.85	23.40	deleterious	0.23	0.55	0.62	disease	0.93	disease	0.8	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.34	0.9	3.51	7.83	0.68	P	0.92	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7007	7007	C	A	MI.4234	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1104	368	H	Q	caC/caA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.14	deleterious	-4.33	deleterious	-4.38	high_impact	4.46	0.62	neutral	0.04	damaging	4.02	23.60	deleterious	0.39	0.55	0.67	disease	0.84	disease	0.77	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.55	0.9	3.51	7.83	0.55	P	0.83	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7007	7007	C	G	MI.4235	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1104	368	H	Q	caC/caG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.14	deleterious	-4.33	deleterious	-4.38	high_impact	4.46	0.62	neutral	0.04	damaging	3.70	23.30	deleterious	0.39	0.55	0.67	disease	0.84	disease	0.77	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.55	0.9	3.51	7.83	0.55	P	0.83	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7008	7008	G	A	MI.4236	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1105	369	D	N	Gac/Aac	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.9	neutral	-0.11	deleterious	-2.75	high_impact	4.15	0.48	damaging	0.05	damaging	4.38	24.10	deleterious	0.53	0.6	0.39	neutral	0.82	disease	0.65	disease	0.59	disease	2	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.73	high_impact	0.70	0.9	4.48	7.96	0.39	N	0.89	disease_causing	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7008	7008	G	C	MI.4237	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1105	369	D	H	Gac/Cac	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-5.05	deleterious	-3.85	high_impact	5.19	0.58	damaging	0.04	damaging	3.74	23.30	deleterious	0.28	0.55	0.86	disease	0.88	disease	0.79	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.63	0.9	4.48	7.96	0.65	P	0.97	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7008	7008	G	T	MI.4238	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1105	369	D	Y	Gac/Tac	-4.5	0	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-6.25	deleterious	-4.96	high_impact	4.84	0.55	damaging	0.05	damaging	4.01	23.60	deleterious	0.18	0.55	0.92	disease	0.94	disease	0.78	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.92	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.46	0.9	4.48	7.96	0.56	P	0.94	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7009	7009	A	C	MI.4239	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1106	369	D	A	gAc/gCc	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.61	deleterious	-4.41	high_impact	4.84	0.63	neutral	0.09	damaging	3.78	23.40	deleterious	0.23	0.55	0.74	disease	0.84	disease	0.75	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.57	0.9	4.48	7.96	0.73	P	0.85	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8725	8725	A	G	MI.424	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	199	67	T	A	Acc/Gcc	-1.03	0	0.01	benign	0.01	neutral	0.39	neutral	4.38	neutral	-0.23	neutral	-2.14	low_impact	0.9	0.96	neutral	0.78	neutral	1.38	12.66	neutral	0.61	0.7	0.54	disease	0.56	disease	0.42	neutral	0.49	neutral	0	0.6	neutral	0.69	deleterious	-6	neutral	0.20	neutral	1.14	medium_impact	0.18	medium_impact	-0.33	medium_impact	0.41	0.9	13.27	10.97	0.28	N	0.63	polymorphism	1	0.03	rs879216744	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7009	7009	A	T	MI.4240	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1106	369	D	V	gAc/gTc	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-5.46	deleterious	-4.96	high_impact	5.19	0.55	damaging	0.05	damaging	4.00	23.60	deleterious	0.17	0.55	0.87	disease	0.93	disease	0.78	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.40	0.9	4.48	7.96	0.67	P	0.93	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7009	7009	A	G	MI.4241	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1106	369	D	G	gAc/gGc	5.22	1	0	probably_damaging	1	deleterious	0	neutral	2.84	deleterious	-3.15	deleterious	-3.86	high_impact	4.5	0.58	damaging	0.06	damaging	4.17	23.80	deleterious	0.22	0.55	0.78	disease	0.89	disease	0.75	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.54	0.9	4.48	7.96	0.54	P	0.85	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7010	7010	C	G	MI.4242	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1107	369	D	E	gaC/gaG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-2.41	neutral	-2.2	high_impact	3.87	0.49	damaging	0.07	damaging	3.96	23.60	deleterious	0.44	0.55	0.57	disease	0.82	disease	0.64	disease	0.6	disease	2	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.47	high_impact	0.60	0.9	4.48	7.96	0.5	P	0.65	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7010	7010	C	A	MI.4243	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1107	369	D	E	gaC/gaA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-2.41	neutral	-2.2	high_impact	3.87	0.49	damaging	0.07	damaging	4.29	24.00	deleterious	0.44	0.55	0.57	disease	0.82	disease	0.64	disease	0.6	disease	2	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.47	high_impact	0.60	0.9	4.48	7.96	0.5	P	0.65	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7011	7011	A	G	MI.4244	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1108	370	T	A	Acg/Gcg	-1.49	0	0	probably_damaging	0.99	deleterious	0	neutral	1.43	deleterious	-6.92	deleterious	-2.75	high_impact	5.16	0.72	neutral	0.1	damaging	3.53	23.10	deleterious	0.43	0.55	0.55	disease	0.63	disease	0.74	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	3.67	high_impact	0.59	0.9	2.14	6.69	0.66	P	0.69	disease_causing	0.95	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7011	7011	A	T	MI.4245	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1108	370	T	S	Acg/Tcg	-1.49	0	0	probably_damaging	0.99	deleterious	0.01	neutral	1.67	deleterious	-3.33	neutral	-2.19	medium_impact	3.1	0.66	neutral	0.09	damaging	3.30	22.90	deleterious	0.4	0.55	0.33	neutral	0.68	disease	0.62	disease	0.37	neutral	3	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-2.64	low_impact	-0.92	medium_impact	1.76	medium_impact	0.75	0.9	2.14	6.69	0.27	N	0.79	disease_causing	0.88	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7011	7011	A	C	MI.4246	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1108	370	T	P	Acg/Ccg	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	1.42	deleterious	-8.28	deleterious	-3.3	high_impact	5.16	0.55	damaging	0.08	damaging	3.56	23.10	deleterious	0.16	0.55	0.8	disease	0.76	disease	0.76	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.60	0.9	2.14	6.69	0.64	P	0.92	disease_causing	0.99	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7012	7012	C	T	MI.4247	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1109	370	T	M	aCg/aTg	8.69	1	0	probably_damaging	1	deleterious	0	neutral	1.41	deleterious	-9.37	deleterious	-3.3	high_impact	5.16	0.69	neutral	0.07	damaging	4.21	23.90	deleterious	0.36	0.55	0.84	disease	0.77	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.74	0.9	2.14	6.69	0.67	P	0.96	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7012	7012	C	A	MI.4248	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1109	370	T	K	aCg/aAg	8.69	1	0	probably_damaging	1	deleterious	0	neutral	1.42	deleterious	-8.11	deleterious	-3.3	high_impact	5.16	0.62	neutral	0.06	damaging	4.65	24.50	deleterious	0.22	0.55	0.55	disease	0.82	disease	0.83	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.71	0.9	2.14	6.69	0.7	P	0.88	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7014	7014	T	A	MI.4249	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1111	371	Y	N	Tac/Aac	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	2.48	deleterious	-4.57	deleterious	-4.95	high_impact	5.19	0.51	damaging	0.09	damaging	4.20	23.90	deleterious	0.24	0.55	0.79	disease	0.88	disease	0.8	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.21	0.9	4.29	7.68	0.64	P	0.94	polymorphism	0.67	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8725	8725	A	T	MI.425	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	199	67	T	S	Acc/Tcc	-1.03	0	0.01	benign	0.19	neutral	0.45	neutral	4.39	neutral	-0.23	neutral	-1.04	neutral_impact	0.6	0.91	neutral	0.86	neutral	0.18	4.50	deleterious	0.64	0.7	0.38	neutral	0.49	neutral	0.25	neutral	0.46	neutral	1	0.46	neutral	0.63	deleterious	-6	neutral	0.33	neutral	-0.16	medium_impact	0.24	medium_impact	-0.58	medium_impact	0.78	0.9	13.27	10.97	0.37	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7014	7014	T	C	MI.4250	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1111	371	Y	H	Tac/Cac	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.44	deleterious	-2.75	high_impact	4.64	0.52	damaging	0.09	damaging	3.72	23.30	deleterious	0.33	0.55	0.8	disease	0.85	disease	0.85	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.19	high_impact	0.44	0.9	4.29	7.68	0.55	P	0.61	polymorphism	0.96	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7014	7014	T	G	MI.4251	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1111	371	Y	D	Tac/Gac	-6.12	0	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.89	deleterious	-5.5	high_impact	5.19	0.54	damaging	0.07	damaging	4.14	23.80	deleterious	0.14	0.55	0.84	disease	0.91	disease	0.85	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.28	0.9	4.29	7.68	0.62	P	0.98	polymorphism	0.73	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7015	7015	A	C	MI.4252	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1112	371	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-3.32	deleterious	-4.94	high_impact	5.19	0.62	neutral	0.11	damaging	3.87	23.50	deleterious	0.22	0.55	0.68	disease	0.89	disease	0.78	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.26	0.9	4.29	7.68	0.76	P	0.90	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7015	7015	A	G	MI.4253	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1112	371	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.45	deleterious	-4.91	deleterious	-4.95	high_impact	5.19	0.53	damaging	0.06	damaging	3.67	23.30	deleterious	0.3	0.55	0.86	disease	0.89	disease	0.81	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.24	0.9	4.29	7.68	0.69	P	0.89	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7015	7015	A	T	MI.4254	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1112	371	Y	F	tAc/tTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-3.1	neutral	-2.2	high_impact	4.04	0.47	damaging	0.08	damaging	3.59	23.20	deleterious	0.26	0.55	0.47	neutral	0.88	disease	0.73	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.63	high_impact	0.52	0.9	4.29	7.68	0.6	P	0.50	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7017	7017	T	C	MI.4255	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1114	372	Y	H	Tac/Cac	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-4.56	deleterious	-2.75	high_impact	5.08	0.61	neutral	0.05	damaging	3.76	23.30	deleterious	0.3	0.55	0.79	disease	0.87	disease	0.75	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.42	0.9	3.9	7.79	0.69	P	0.61	disease_causing	0.98	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7017	7017	T	A	MI.4256	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1114	372	Y	N	Tac/Aac	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.74	deleterious	-5.56	deleterious	-4.94	high_impact	4.39	0.56	damaging	0.05	damaging	4.33	24.00	deleterious	0.25	0.55	0.9	disease	0.89	disease	0.7	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.24	0.9	3.9	7.79	0.33	N	0.94	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7017	7017	T	G	MI.4257	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1114	372	Y	D	Tac/Gac	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-6.63	deleterious	-5.5	high_impact	5.08	0.48	damaging	0.04	damaging	4.08	23.70	deleterious	0.15	0.55	0.95	disease	0.92	disease	0.77	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.27	0.9	3.9	7.79	0.53	P	0.98	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7018	7018	A	G	MI.4258	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1115	372	Y	C	tAc/tGc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-6.46	deleterious	-4.95	high_impact	5.08	0.56	damaging	0.04	damaging	3.68	23.30	deleterious	0.29	0.55	0.95	disease	0.9	disease	0.7	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.22	0.9	3.9	7.79	0.64	P	0.89	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7018	7018	A	T	MI.4259	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1115	372	Y	F	tAc/tTc	5.91	1	0	probably_damaging	1	neutral	0.13	neutral	2.94	neutral	0.67	neutral	-2.2	medium_impact	2.67	0.6	damaging	0.04	damaging	3.55	23.10	deleterious	0.26	0.55	0.16	neutral	0.86	disease	0.42	neutral	0.37	neutral	3	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.58	low_impact	-0.27	medium_impact	1.37	medium_impact	0.48	0.9	3.9	7.79	0.45	N	0.50	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8726	8726	C	G	MI.426	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	200	67	T	S	aCc/aGc	3.14	0.77	0	benign	0.19	neutral	0.45	neutral	4.39	neutral	-0.23	neutral	-1.04	neutral_impact	0.6	0.91	neutral	0.86	neutral	0.31	5.77	deleterious	0.64	0.7	0.38	neutral	0.49	neutral	0.25	neutral	0.46	neutral	1	0.46	neutral	0.63	deleterious	-6	neutral	0.33	neutral	-0.16	medium_impact	0.24	medium_impact	-0.58	medium_impact	0.78	0.9	13.27	10.97	0.32	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7018	7018	A	C	MI.4260	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1115	372	Y	S	tAc/tCc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-4.97	deleterious	-4.95	high_impact	5.08	0.61	neutral	0.06	damaging	3.83	23.40	deleterious	0.23	0.55	0.89	disease	0.9	disease	0.66	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.59	high_impact	0.28	0.9	3.9	7.79	0.69	P	0.90	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7020	7020	G	A	MI.4261	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1117	373	V	I	Gtt/Att	-3.11	0	0	probably_damaging	0.98	deleterious	0.02	neutral	2.4	neutral	-2.52	neutral	-0.54	high_impact	3.91	0.67	neutral	0.17	damaging	3.78	23.40	deleterious	0.37	0.55	0.38	neutral	0.62	disease	0.55	disease	0.54	disease	1	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.35	low_impact	-0.75	medium_impact	2.51	high_impact	0.84	0.9	1.75	6.65	0.41	N	0.24	polymorphism	0.82	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7020	7020	G	T	MI.4262	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1117	373	V	F	Gtt/Ttt	-3.11	0	0	probably_damaging	1	deleterious	0	neutral	2.19	deleterious	-6.83	deleterious	-2.71	high_impact	5.19	0.57	damaging	0.11	damaging	3.99	23.60	deleterious	0.13	0.55	0.76	disease	0.92	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.69	high_impact	0.54	0.9	1.75	6.65	0.64	P	0.86	disease_causing	0.89	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7020	7020	G	C	MI.4263	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1117	373	V	L	Gtt/Ctt	-3.11	0	0	probably_damaging	0.98	deleterious	0	neutral	2.3	deleterious	-3.76	neutral	-1.63	high_impact	4.38	0.62	neutral	0.14	damaging	3.68	23.30	deleterious	0.24	0.55	0.4	neutral	0.8	disease	0.56	disease	0.65	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-1.48	low_impact	2.95	high_impact	0.68	0.9	1.75	6.65	0.38	N	0.55	polymorphism	0.58	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7021	7021	T	C	MI.4264	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1118	373	V	A	gTt/gCt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.24	deleterious	-5.86	neutral	-2.17	high_impact	4.64	0.53	damaging	0.17	damaging	3.67	23.30	deleterious	0.23	0.55	0.68	disease	0.68	disease	0.69	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.19	high_impact	0.44	0.9	1.75	6.65	0.6	P	0.47	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7021	7021	T	G	MI.4265	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1118	373	V	G	gTt/gGt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.19	deleterious	-8.26	deleterious	-3.8	high_impact	4.84	0.61	neutral	0.16	damaging	3.94	23.50	deleterious	0.1	0.55	0.87	disease	0.85	disease	0.68	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.47	0.9	1.75	6.65	0.67	P	0.71	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7021	7021	T	A	MI.4266	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1118	373	V	D	gTt/gAt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.18	deleterious	-9	deleterious	-3.8	high_impact	4.84	0.63	neutral	0.13	damaging	4.54	24.30	deleterious	0.09	0.55	0.91	disease	0.9	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.37	high_impact	0.50	0.9	1.75	6.65	0.69	P	0.83	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7023	7023	G	A	MI.4267	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1120	374	V	M	Gta/Ata	-5.89	0	0	probably_damaging	1	deleterious	0	neutral	2.25	deleterious	-5.28	neutral	-1.61	high_impact	4.76	0.69	neutral	0.07	damaging	3.80	23.40	deleterious	0.31	0.55	0.68	disease	0.78	disease	0.73	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.93	0.95	5.65	8.39	0.61	P	0.82	polymorphism	0.91	0.25	.	.	.	.	.	.	COSM1138397	.	.	G7023A	MELAS-like syndrome	-	+	Reported	1	.	P	P	damaging
chrM	7023	7023	G	C	MI.4268	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1120	374	V	L	Gta/Cta	-5.89	0	0	probably_damaging	0.99	deleterious	0	neutral	2.31	deleterious	-3.62	neutral	-1.61	high_impact	4.42	0.67	neutral	0.05	damaging	3.59	23.20	deleterious	0.3	0.55	0.47	neutral	0.82	disease	0.68	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.98	high_impact	0.69	0.9	5.65	8.39	0.4	N	0.55	polymorphism	0.92	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7023	7023	G	T	MI.4269	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1120	374	V	L	Gta/Tta	-5.89	0	0	probably_damaging	0.99	deleterious	0	neutral	2.31	deleterious	-3.62	neutral	-1.61	high_impact	4.42	0.67	neutral	0.05	damaging	3.75	23.30	deleterious	0.3	0.55	0.47	neutral	0.82	disease	0.68	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.98	high_impact	0.69	0.9	5.65	8.39	0.4	N	0.55	polymorphism	0.92	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8726	8726	C	T	MI.427	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	200	67	T	I	aCc/aTc	3.14	0.77	0	possibly_damaging	0.48	neutral	0.3	neutral	4.34	neutral	-1.22	deleterious	-3.67	neutral_impact	0.24	0.87	neutral	0.53	neutral	2.17	17.30	deleterious	0.41	0.65	0.66	disease	0.8	disease	0.5	neutral	0.69	disease	4	0.67	neutral	0.41	neutral	-3	neutral	0.58	deleterious	-0.72	medium_impact	0.08	medium_impact	-0.89	medium_impact	0.50	0.9	13.27	10.97	0.3	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7024	7024	T	A	MI.4270	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1121	374	V	E	gTa/gAa	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.24	deleterious	-6.43	deleterious	-3.23	high_impact	5.11	0.65	neutral	0.08	damaging	4.69	24.60	deleterious	0.12	0.55	0.81	disease	0.9	disease	0.81	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.56	0.9	5.65	8.39	0.73	P	0.84	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7024	7024	T	G	MI.4271	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1121	374	V	G	gTa/gGa	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.24	deleterious	-6.45	deleterious	-3.77	high_impact	5.11	0.65	neutral	0.1	damaging	3.92	23.50	deleterious	0.15	0.55	0.8	disease	0.87	disease	0.73	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.55	0.9	5.65	8.39	0.72	P	0.71	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7024	7024	T	C	MI.4272	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1121	374	V	A	gTa/gCa	9.38	1	0	probably_damaging	1	deleterious	0	neutral	2.39	neutral	-2.58	neutral	-2.15	high_impact	4.56	0.67	neutral	0.1	damaging	3.65	23.20	deleterious	0.28	0.55	0.59	disease	0.7	disease	0.69	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.11	high_impact	0.58	0.9	5.65	8.39	0.54	P	0.47	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7026	7026	G	A	MI.4273	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1123	375	A	T	Gcc/Acc	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.04	deleterious	-5.83	neutral	-2.15	high_impact	4.76	0.45	damaging	0.13	damaging	4.33	24.00	deleterious	0.19	0.55	0.7	disease	0.86	disease	0.59	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.52	0.9	3.12	7.31	0.62	P	0.20	disease_causing	1	0.26	.	.	.	.	.	.	COSM1133250	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7026	7026	G	C	MI.4274	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1123	375	A	P	Gcc/Ccc	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.02	deleterious	-7.06	deleterious	-2.68	high_impact	5.11	0.46	damaging	0.11	damaging	3.89	23.50	deleterious	0.09	0.55	0.85	disease	0.85	disease	0.77	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.75	0.9	3.12	7.31	0.64	P	0.85	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7026	7026	G	T	MI.4275	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1123	375	A	S	Gcc/Tcc	-3.34	0	0	probably_damaging	1	neutral	0.09	neutral	2.1	deleterious	-3.88	neutral	-1.6	high_impact	3.73	0.6	neutral	0.11	damaging	3.79	23.40	deleterious	0.16	0.55	0.5	neutral	0.83	disease	0.57	disease	0.6	disease	2	1	deleterious	0.05	neutral	2	deleterious	0.84	deleterious	-3.58	low_impact	-0.37	medium_impact	2.35	high_impact	0.79	0.9	3.12	7.31	0.31	N	0.64	disease_causing	0.99	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7027	7027	C	T	MI.4276	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1124	375	A	V	gCc/gTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.04	deleterious	-5.44	neutral	-2.15	high_impact	5.11	0.45	damaging	0.08	damaging	4.52	24.30	deleterious	0.22	0.55	0.82	disease	0.89	disease	0.66	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.62	0.9	3.12	7.31	0.71	P	0.75	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7027	7027	C	G	MI.4277	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1124	375	A	G	gCc/gGc	7.53	1	0	probably_damaging	0.99	neutral	0.08	neutral	2.55	neutral	-1.11	neutral	-2.09	medium_impact	2.58	0.5	damaging	0.12	damaging	4.04	23.70	deleterious	0.13	0.55	0.24	neutral	0.77	disease	0.45	neutral	0.4	neutral	2	1	deleterious	0.05	neutral	1	deleterious	0.76	deleterious	-2.64	low_impact	-0.4	medium_impact	1.28	medium_impact	0.80	0.9	3.12	7.31	0.5	P	0.56	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7027	7027	C	A	MI.4278	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1124	375	A	D	gCc/gAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.02	deleterious	-7.76	deleterious	-3.21	high_impact	5.11	0.51	damaging	0.09	damaging	4.71	24.60	deleterious	0.07	0.55	0.89	disease	0.93	disease	0.75	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.62	high_impact	0.66	0.9	3.12	7.31	0.64	P	0.89	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7029	7029	C	G	MI.4279	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1126	376	H	D	Cac/Gac	-9.13	0	0	probably_damaging	1	deleterious	0	deleterious	-1.53	deleterious	-13.51	deleterious	-4.8	high_impact	5.17	0.49	damaging	0.03	damaging	3.96	23.60	deleterious	0.18	0.55	0.78	disease	0.91	disease	0.84	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.33	0.9	7.6	8.33	0.44	N	0.97	disease_causing	0.8	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8726	8726	C	A	MI.428	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	200	67	T	N	aCc/aAc	3.14	0.77	0	possibly_damaging	0.64	neutral	0.26	neutral	4.39	neutral	-0.43	neutral	-1.83	neutral_impact	0.28	0.83	neutral	0.57	neutral	3.27	22.80	deleterious	0.71	0.75	0.47	neutral	0.71	disease	0.28	neutral	0.52	disease	0	0.77	neutral	0.31	neutral	-3	neutral	0.60	deleterious	-0.99	medium_impact	0.04	medium_impact	-0.86	medium_impact	0.74	0.9	13.27	10.97	0.32	N	0.90	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7029	7029	C	A	MI.4280	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1126	376	H	N	Cac/Aac	-9.13	0	0	probably_damaging	1	deleterious	0	deleterious	-1.52	deleterious	-11.53	deleterious	-3.73	high_impact	5.17	0.55	damaging	0.04	damaging	4.03	23.60	deleterious	0.27	0.55	0.81	disease	0.88	disease	0.78	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.36	0.9	7.6	8.33	0.53	P	0.86	disease_causing	0.54	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7029	7029	C	T	MI.4281	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1126	376	H	Y	Cac/Tac	-9.13	0	0	probably_damaging	1	deleterious	0	deleterious	-1.52	deleterious	-11.61	deleterious	-3.2	high_impact	4.82	0.57	damaging	0.03	damaging	3.84	23.40	deleterious	0.25	0.55	0.87	disease	0.92	disease	0.79	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.35	high_impact	0.40	0.9	7.6	8.33	0.53	N	0.72	disease_causing	0.59	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7030	7030	A	T	MI.4282	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1127	376	H	L	cAc/cTc	4.52	1	0	probably_damaging	1	deleterious	0	deleterious	-1.53	deleterious	-14.51	deleterious	-5.86	high_impact	5.17	0.65	neutral	0.03	damaging	3.97	23.60	deleterious	0.16	0.55	0.86	disease	0.94	disease	0.79	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.37	0.9	7.6	8.33	0.51	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7030	7030	A	C	MI.4283	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1127	376	H	P	cAc/cCc	4.52	1	0	probably_damaging	1	deleterious	0	deleterious	-1.53	deleterious	-13.85	deleterious	-5.33	high_impact	5.17	0.51	damaging	0.04	damaging	3.35	22.90	deleterious	0.19	0.55	0.89	disease	0.9	disease	0.86	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.39	0.9	7.6	8.33	0.5	P	0.90	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7030	7030	A	G	MI.4284	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1127	376	H	R	cAc/cGc	4.52	1	0	probably_damaging	1	deleterious	0	deleterious	-1.51	deleterious	-11.11	deleterious	-4.27	high_impact	5.17	0.59	damaging	0.03	damaging	3.13	22.60	deleterious	0.3	0.55	0.81	disease	0.91	disease	0.82	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.34	0.9	7.6	8.33	0.59	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7031	7031	C	A	MI.4285	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1128	376	H	Q	caC/caA	7.07	1	0	probably_damaging	1	deleterious	0	deleterious	-1.52	deleterious	-12.23	deleterious	-4.26	high_impact	5.17	0.62	neutral	0.04	damaging	3.92	23.50	deleterious	0.28	0.55	0.83	disease	0.87	disease	0.8	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.42	0.9	7.6	8.33	0.6	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7031	7031	C	G	MI.4286	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1128	376	H	Q	caC/caG	7.07	1	0	probably_damaging	1	deleterious	0	deleterious	-1.52	deleterious	-12.23	deleterious	-4.26	high_impact	5.17	0.62	neutral	0.04	damaging	3.65	23.20	deleterious	0.28	0.55	0.83	disease	0.87	disease	0.8	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.68	high_impact	0.42	0.9	7.6	8.33	0.6	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7032	7032	T	C	MI.4287	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1129	377	F	L	Ttc/Ctc	-2.65	0	0	probably_damaging	0.98	deleterious	0	neutral	2.57	deleterious	-3.85	deleterious	-3.2	high_impact	3.52	0.75	neutral	0.05	damaging	4.26	23.90	deleterious	0.29	0.55	0.35	neutral	0.83	disease	0.67	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.35	low_impact	-1.48	low_impact	2.15	high_impact	0.56	0.9	1.56	6.85	0.3	N	0.83	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7032	7032	T	A	MI.4288	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1129	377	F	I	Ttc/Atc	-2.65	0	0	probably_damaging	0.99	deleterious	0	neutral	2.53	deleterious	-4.45	deleterious	-3.2	high_impact	4.8	0.76	neutral	0.07	damaging	4.66	24.50	deleterious	0.16	0.55	0.66	disease	0.87	disease	0.72	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.33	high_impact	0.56	0.9	1.56	6.85	0.66	P	0.88	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7032	7032	T	G	MI.4289	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1129	377	F	V	Ttc/Gtc	-2.65	0	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-4.13	deleterious	-3.73	high_impact	5.14	0.74	neutral	0.07	damaging	4.26	23.90	deleterious	0.23	0.55	0.67	disease	0.91	disease	0.74	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.61	0.9	1.56	6.85	0.7	P	0.84	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8728	8728	T	G	MI.429	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	202	68	W	G	Tga/Gga	-1.95	0	0	probably_damaging	0.99	neutral	0.21	neutral	4.28	neutral	-2.71	deleterious	-11.52	medium_impact	2.92	0.6	neutral	0.43	neutral	3.81	23.40	deleterious	0.29	0.65	0.67	disease	0.85	disease	0.79	disease	0.66	disease	3	0.99	deleterious	0.11	neutral	1	deleterious	0.81	deleterious	-2.65	low_impact	-0.03	medium_impact	1.41	medium_impact	0.36	0.9	49.56	8.58	0.41	N	1.00	disease_causing	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7033	7033	T	A	MI.4290	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1130	377	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.54	deleterious	-5.3	neutral	-1.6	high_impact	4.25	0.76	neutral	0.06	damaging	4.35	24.10	deleterious	0.21	0.55	0.65	disease	0.84	disease	0.69	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.35	low_impact	-1.48	low_impact	2.83	high_impact	0.66	0.9	1.56	6.85	0.52	N	0.59	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7033	7033	T	G	MI.4291	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1130	377	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.47	deleterious	-7.09	deleterious	-4.27	high_impact	5.14	0.78	neutral	0.06	damaging	4.21	23.90	deleterious	0.22	0.55	0.91	disease	0.87	disease	0.74	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.65	high_impact	0.40	0.9	1.56	6.85	0.67	P	0.91	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7033	7033	T	C	MI.4292	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1130	377	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-5.02	deleterious	-4.27	high_impact	4.17	0.78	neutral	0.08	damaging	4.36	24.10	deleterious	0.2	0.55	0.8	disease	0.88	disease	0.73	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.75	high_impact	0.51	0.9	1.56	6.85	0.5	N	0.84	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7034	7034	C	G	MI.4293	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1131	377	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.57	deleterious	-3.85	deleterious	-3.2	high_impact	3.52	0.75	neutral	0.05	damaging	4.47	24.20	deleterious	0.29	0.55	0.35	neutral	0.83	disease	0.67	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.35	low_impact	-1.48	low_impact	2.15	high_impact	0.56	0.9	1.56	6.85	0.47	N	0.83	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7034	7034	C	A	MI.4294	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1131	377	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.57	deleterious	-3.85	deleterious	-3.2	high_impact	3.52	0.75	neutral	0.05	damaging	4.75	24.70	deleterious	0.29	0.55	0.35	neutral	0.83	disease	0.67	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.35	low_impact	-1.48	low_impact	2.15	high_impact	0.56	0.9	1.56	6.85	0.5	N	0.83	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7035	7035	C	A	MI.4295	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1132	378	H	N	Cac/Aac	-0.57	0.14	0	probably_damaging	1	deleterious	0	deleterious	-1.54	deleterious	-11.57	deleterious	-3.72	high_impact	5.16	0.54	damaging	0.04	damaging	3.96	23.60	deleterious	0.29	0.55	0.84	disease	0.89	disease	0.79	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.47	0.9	3.9	8.09	0.54	P	0.86	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7035	7035	C	G	MI.4296	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1132	378	H	D	Cac/Gac	-0.57	0.14	0	probably_damaging	1	deleterious	0	deleterious	-1.55	deleterious	-13.55	deleterious	-4.79	high_impact	5.16	0.49	damaging	0.04	damaging	3.95	23.60	deleterious	0.19	0.55	0.87	disease	0.91	disease	0.84	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.48	0.9	3.9	8.09	0.49	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7035	7035	C	T	MI.4297	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1132	378	H	Y	Cac/Tac	-0.57	0.14	0	probably_damaging	1	deleterious	0.01	deleterious	-1.53	deleterious	-10.63	deleterious	-3.19	high_impact	4.12	0.55	damaging	0.04	damaging	3.78	23.40	deleterious	0.29	0.55	0.89	disease	0.92	disease	0.81	disease	0.86	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-0.92	medium_impact	2.71	high_impact	0.54	0.9	3.9	8.09	0.39	N	0.72	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7036	7036	A	G	MI.4298	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1133	378	H	R	cAc/cGc	7.3	1	0	probably_damaging	1	deleterious	0	deleterious	-1.55	deleterious	-13.21	deleterious	-4.25	high_impact	4.62	0.56	damaging	0.04	damaging	3.07	22.40	deleterious	0.33	0.55	0.35	neutral	0.92	disease	0.79	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.54	0.9	3.9	8.09	0.45	N	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7036	7036	A	T	MI.4299	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1133	378	H	L	cAc/cTc	7.3	1	0	probably_damaging	1	deleterious	0	deleterious	-1.55	deleterious	-14.92	deleterious	-5.85	high_impact	5.16	0.63	neutral	0.03	damaging	3.92	23.50	deleterious	0.17	0.55	0.86	disease	0.94	disease	0.78	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.48	0.9	3.9	8.09	0.52	P	0.92	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8545	8545	G	C	MI.43	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	19	7	A	P	Gct/Cct	-1.03	0	0.01	benign	0.25	deleterious	0.02	neutral	4.61	neutral	-2.12	neutral	-1.51	low_impact	1.7	0.72	neutral	0.36	neutral	2.08	16.70	deleterious	0.23	0.65	0.7	disease	0.79	disease	0.62	disease	0.77	disease	5	0.98	neutral	0.39	neutral	-2	neutral	0.60	deleterious	-0.3	medium_impact	-0.66	medium_impact	0.36	medium_impact	0.77	0.9	9.29	10.06	0.28	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8728	8728	T	C	MI.430	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	202	68	W	R	Tga/Cga	-1.95	0	0	probably_damaging	1	neutral	0.15	neutral	4.31	deleterious	-3.17	deleterious	-12.41	high_impact	3.6	0.48	damaging	0.25	damaging	3.43	23.00	deleterious	0.38	0.65	0.74	disease	0.91	disease	0.83	disease	0.86	disease	7	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.13	medium_impact	1.99	medium_impact	0.36	0.9	49.56	8.58	0.47	N	0.97	disease_causing	0.9	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7036	7036	A	C	MI.4300	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1133	378	H	P	cAc/cCc	7.3	1	0	probably_damaging	1	deleterious	0	deleterious	-1.55	deleterious	-13.3	deleterious	-5.32	high_impact	5.16	0.47	damaging	0.04	damaging	3.29	22.80	deleterious	0.2	0.55	0.91	disease	0.9	disease	0.87	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.67	high_impact	0.43	0.9	3.9	8.09	0.57	P	0.90	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7037	7037	C	A	MI.4301	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1134	378	H	Q	caC/caA	8.69	1	0	probably_damaging	1	deleterious	0	deleterious	-1.54	deleterious	-12.1	deleterious	-4.25	high_impact	4.62	0.59	damaging	0.04	damaging	3.89	23.50	deleterious	0.33	0.55	0.77	disease	0.86	disease	0.78	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.54	0.9	3.9	8.09	0.49	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7037	7037	C	G	MI.4302	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1134	378	H	Q	caC/caG	8.69	1	0	probably_damaging	1	deleterious	0	deleterious	-1.54	deleterious	-12.1	deleterious	-4.25	high_impact	4.62	0.59	damaging	0.04	damaging	3.64	23.20	deleterious	0.33	0.55	0.77	disease	0.86	disease	0.78	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.54	0.9	3.9	8.09	0.49	P	0.83	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7038	7038	T	C	MI.4303	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1135	379	Y	H	Tat/Cat	-0.1	0.79	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.09	deleterious	-2.66	high_impact	4.79	0.66	neutral	0.11	damaging	3.76	23.30	deleterious	0.33	0.55	0.78	disease	0.86	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.43	0.9	2.34	7.1	0.68	P	0.61	disease_causing	0.99	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7038	7038	T	A	MI.4304	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1135	379	Y	N	Tat/Aat	-0.1	0.79	0	probably_damaging	1	deleterious	0	neutral	2.58	neutral	-2.43	deleterious	-4.8	high_impact	4.79	0.59	damaging	0.12	damaging	4.31	24.00	deleterious	0.29	0.55	0.61	disease	0.9	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.27	0.9	2.34	7.1	0.65	P	0.94	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7038	7038	T	G	MI.4305	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1135	379	Y	D	Tat/Gat	-0.1	0.79	0	probably_damaging	1	deleterious	0	neutral	2.55	deleterious	-4.69	deleterious	-5.33	high_impact	5.13	0.63	neutral	0.1	damaging	4.04	23.70	deleterious	0.17	0.55	0.83	disease	0.92	disease	0.8	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.33	0.9	2.34	7.1	0.65	P	0.98	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7039	7039	A	C	MI.4306	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1136	379	Y	S	tAt/tCt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	-2.44	deleterious	-4.79	high_impact	4.79	0.7	neutral	0.15	damaging	3.94	23.50	deleterious	0.25	0.55	0.63	disease	0.91	disease	0.68	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.31	0.9	2.34	7.1	0.7	P	0.90	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7039	7039	A	G	MI.4307	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1136	379	Y	C	tAt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-3.86	deleterious	-4.8	high_impact	5.13	0.62	neutral	0.09	damaging	3.70	23.30	deleterious	0.31	0.55	0.81	disease	0.91	disease	0.73	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.64	high_impact	0.26	0.9	2.34	7.1	0.72	P	0.89	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7039	7039	A	T	MI.4308	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1136	379	Y	F	tAt/tTt	7.53	1	0	probably_damaging	0.99	deleterious	0.03	neutral	2.61	neutral	-1.45	neutral	-2.13	medium_impact	3.48	0.51	damaging	0.13	damaging	3.64	23.20	deleterious	0.31	0.55	0.5	disease	0.91	disease	0.64	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-2.64	low_impact	-0.65	medium_impact	2.11	high_impact	0.58	0.9	2.34	7.1	0.5	P	0.50	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7041	7041	G	A	MI.4309	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1138	380	V	I	Gtc/Atc	-0.8	0.07	0	probably_damaging	0.98	deleterious	0	neutral	2.54	neutral	-1.73	neutral	-0.53	high_impact	4.14	0.52	damaging	0.6	neutral	3.78	23.40	deleterious	0.46	0.55	0.53	disease	0.75	disease	0.62	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.35	low_impact	-1.48	low_impact	2.72	high_impact	0.91	0.95	1.75	6.67	0.57	P	0.24	disease_causing	0.99	0.07	.	not_provided	Mitochondrial_DNA-related_disorder	434700	MedGen:CN552492	.	.	.	.	G7041A	Prostate Cancer	+	-	Reported	1	.	P	P	damaging
chrM	8729	8729	G	C	MI.431	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	203	68	W	S	tGa/tCa	5.91	1	0	probably_damaging	1	neutral	0.55	neutral	4.36	neutral	-2.22	deleterious	-12.36	medium_impact	2.08	0.58	damaging	0.46	neutral	3.99	23.60	deleterious	0.3	0.65	0.54	disease	0.88	disease	0.76	disease	0.65	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.83	deleterious	-3.6	low_impact	0.34	medium_impact	0.69	medium_impact	0.37	0.9	49.56	8.58	0.43	N	0.98	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7041	7041	G	C	MI.4310	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1138	380	V	L	Gtc/Ctc	-0.8	0.07	0	probably_damaging	0.98	deleterious	0	neutral	2.54	neutral	-2.23	neutral	-1.6	high_impact	4.57	0.57	damaging	0.52	neutral	3.65	23.20	deleterious	0.32	0.55	0.55	disease	0.84	disease	0.65	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.35	low_impact	-1.48	low_impact	3.12	high_impact	0.71	0.9	1.75	6.67	0.52	N	0.55	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7041	7041	G	T	MI.4311	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1138	380	V	F	Gtc/Ttc	-0.8	0.07	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-3.57	deleterious	-2.66	high_impact	4.78	0.53	damaging	0.47	neutral	3.91	23.50	deleterious	0.14	0.55	0.76	disease	0.95	disease	0.7	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.74	0.9	1.75	6.67	0.68	P	0.86	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7042	7042	T	A	MI.4312	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1139	380	V	D	gTc/gAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.44	deleterious	-5.55	deleterious	-3.73	high_impact	5.12	0.57	damaging	0.5	neutral	4.52	24.30	deleterious	0.09	0.55	0.87	disease	0.92	disease	0.77	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.65	0.9	1.75	6.67	0.7	P	0.83	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7042	7042	T	C	MI.4313	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1139	380	V	A	gTc/gCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-2.48	neutral	-2.13	high_impact	3.88	0.56	damaging	0.57	neutral	3.62	23.20	deleterious	0.39	0.55	0.59	disease	0.72	disease	0.63	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.48	high_impact	0.70	0.9	1.75	6.67	0.54	P	0.47	disease_causing	1	0.12	.	.	.	.	.	.	COSM1138398	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7042	7042	T	G	MI.4314	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1139	380	V	G	gTc/gGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.63	deleterious	-3.73	high_impact	5.12	0.58	damaging	0.59	neutral	3.89	23.50	deleterious	0.15	0.55	0.39	neutral	0.88	disease	0.7	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.63	high_impact	0.57	0.9	1.75	6.67	0.62	P	0.71	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7044	7044	C	A	MI.4315	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1141	381	L	M	Cta/Ata	-14.22	0	0	probably_damaging	1	deleterious	0	neutral	2.52	neutral	-1.42	neutral	-1.07	high_impact	3.62	0.56	damaging	0.09	damaging	3.80	23.40	deleterious	0.29	0.55	0.45	neutral	0.74	disease	0.55	disease	0.58	disease	2	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.24	high_impact	0.71	0.9	3.12	6.67	0.27	N	0.59	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7044	7044	C	G	MI.4316	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1141	381	L	V	Cta/Gta	-14.22	0	0	probably_damaging	0.97	deleterious	0	neutral	2.6	neutral	-0.89	neutral	-1.6	medium_impact	3.38	0.53	damaging	0.06	damaging	3.45	23.00	deleterious	0.36	0.55	0.39	neutral	0.85	disease	0.63	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-2.18	low_impact	-1.48	low_impact	2.02	high_impact	0.59	0.9	3.12	6.67	0.27	N	0.66	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7045	7045	T	A	MI.4317	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1142	381	L	Q	cTa/cAa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-5.69	deleterious	-3.2	high_impact	5.09	0.56	damaging	0.05	damaging	4.17	23.80	deleterious	0.18	0.55	0.86	disease	0.89	disease	0.64	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.6	high_impact	0.62	0.9	3.12	6.67	0.61	P	0.82	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7045	7045	T	C	MI.4318	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1142	381	L	P	cTa/cCa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-6.07	deleterious	-3.74	high_impact	5.09	0.41	damaging	0.05	damaging	4.01	23.60	deleterious	0.17	0.55	0.4	neutral	0.88	disease	0.72	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.6	high_impact	0.43	0.9	3.12	6.67	0.49	P	0.83	disease_causing	0.75	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7045	7045	T	G	MI.4319	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1142	381	L	R	cTa/cGa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-5.58	deleterious	-3.2	high_impact	5.09	0.53	damaging	0.04	damaging	4.28	24.00	deleterious	0.17	0.55	0.86	disease	0.95	disease	0.75	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.93	deleterious	-3.58	low_impact	-1.48	low_impact	3.6	high_impact	0.51	0.9	3.12	6.67	0.59	P	0.90	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8729	8729	G	T	MI.432	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	203	68	W	L	tGa/tTa	5.91	1	0	probably_damaging	0.99	neutral	0.37	neutral	4.41	neutral	-0.24	deleterious	-11.52	medium_impact	2.37	0.57	damaging	0.33	neutral	4.20	23.90	deleterious	0.25	0.65	0.53	disease	0.84	disease	0.77	disease	0.77	disease	5	0.99	deleterious	0.19	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	0.16	medium_impact	0.93	medium_impact	0.30	0.9	49.56	8.58	0.46	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7047	7047	T	G	MI.4320	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1144	382	S	A	Tca/Gca	-5.66	0	0	benign	0.07	deleterious	0	neutral	2.8	neutral	-0.06	neutral	-1.6	high_impact	4.36	0.58	damaging	0.13	damaging	3.77	23.40	deleterious	0.39	0.55	0.38	neutral	0.75	disease	0.61	disease	0.66	disease	3	1	deleterious	0.47	neutral	2	deleterious	0.25	neutral	0.3	medium_impact	-1.48	low_impact	2.93	high_impact	0.70	0.9	7.8	8.18	0.4	N	0.35	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7047	7047	T	A	MI.4321	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1144	382	S	T	Tca/Aca	-5.66	0	0	benign	0.06	deleterious	0.02	neutral	2.72	neutral	-1.4	neutral	-1.6	high_impact	4.16	0.51	damaging	0.08	damaging	3.80	23.40	deleterious	0.31	0.55	0.43	neutral	0.8	disease	0.59	disease	0.67	disease	3	0.98	neutral	0.48	deleterious	2	deleterious	0.30	neutral	0.37	medium_impact	-0.75	medium_impact	2.74	high_impact	0.83	0.9	7.8	8.18	0.36	N	0.43	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7047	7047	T	C	MI.4322	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1144	382	S	P	Tca/Cca	-5.66	0	0	benign	0	deleterious	0	neutral	2.68	deleterious	-3.31	deleterious	-2.66	high_impact	4.5	0.36	damaging	0.08	damaging	4.06	23.70	deleterious	0.18	0.55	0.67	disease	0.87	disease	0.77	disease	0.8	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.34	neutral	2.07	high_impact	-1.48	low_impact	3.06	high_impact	0.70	0.9	7.8	8.18	0.51	P	0.91	polymorphism	0.96	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7048	7048	C	G	MI.4323	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1145	382	S	W	tCa/tGa	5.91	1	0	probably_damaging	0.96	deleterious	0	neutral	2.72	neutral	-1.48	deleterious	-3.74	high_impact	5.05	0.49	damaging	0.06	damaging	4.37	24.10	deleterious	0.17	0.55	0.82	disease	0.93	disease	0.69	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.06	low_impact	-1.48	low_impact	3.56	high_impact	0.51	0.9	7.8	8.18	0.66	P	0.94	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7048	7048	C	T	MI.4324	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1145	382	S	L	tCa/tTa	5.91	1	0	benign	0.41	deleterious	0	neutral	2.87	neutral	0.6	deleterious	-3.2	high_impact	4.36	0.55	damaging	0.05	damaging	4.68	24.60	deleterious	0.23	0.55	0.36	neutral	0.91	disease	0.6	disease	0.71	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.57	deleterious	-0.61	medium_impact	-1.48	low_impact	2.93	high_impact	0.85	0.9	7.8	8.18	0.43	N	0.90	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7050	7050	A	G	MI.4325	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1147	383	M	V	Ata/Gta	-8.2	0	0	probably_damaging	0.94	deleterious	0	neutral	2.82	neutral	0.16	neutral	-2.06	high_impact	3.95	0.56	damaging	0.39	neutral	2.90	21.80	deleterious	0.4	0.55	0.3	neutral	0.93	disease	0.69	disease	0.76	disease	5	1	deleterious	0.03	neutral	6	deleterious	0.75	deleterious	-1.88	low_impact	-1.48	low_impact	2.55	high_impact	0.49	0.9	5.26	8.17	0.4	N	0.88	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7050	7050	A	T	MI.4326	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1147	383	M	L	Ata/Tta	-8.2	0	0	probably_damaging	0.91	neutral	0.21	neutral	2.89	neutral	1.04	neutral	-1.5	medium_impact	2.91	0.59	damaging	0.45	neutral	3.54	23.10	deleterious	0.33	0.55	0.16	neutral	0.83	disease	0.48	neutral	0.49	neutral	0	0.94	neutral	0.15	neutral	1	deleterious	0.62	deleterious	-1.7	low_impact	-0.13	medium_impact	1.59	medium_impact	0.44	0.9	5.26	8.17	0.37	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7050	7050	A	C	MI.4327	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1147	383	M	L	Ata/Cta	-8.2	0	0	probably_damaging	0.91	neutral	0.21	neutral	2.89	neutral	1.04	neutral	-1.5	medium_impact	2.91	0.59	damaging	0.45	neutral	3.40	23.00	deleterious	0.33	0.55	0.16	neutral	0.83	disease	0.48	neutral	0.49	neutral	0	0.94	neutral	0.15	neutral	1	deleterious	0.62	deleterious	-1.7	low_impact	-0.13	medium_impact	1.59	medium_impact	0.44	0.9	5.26	8.17	0.37	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7051	7051	T	A	MI.4328	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1148	383	M	K	aTa/aAa	8.69	1	0	probably_damaging	0.97	deleterious	0	neutral	2.76	neutral	-1.19	deleterious	-3.13	high_impact	4.92	0.58	damaging	0.39	neutral	4.34	24.00	deleterious	0.23	0.55	0.58	disease	0.95	disease	0.76	disease	0.88	disease	8	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-2.18	low_impact	-1.48	low_impact	3.44	high_impact	0.46	0.9	5.26	8.17	0.71	P	0.93	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7051	7051	T	C	MI.4329	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1148	383	M	T	aTa/aCa	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.82	neutral	0.19	deleterious	-3.11	high_impact	4.58	0.52	damaging	0.39	neutral	3.10	22.50	deleterious	0.43	0.55	0.42	neutral	0.92	disease	0.68	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.64	low_impact	-1.48	low_impact	3.13	high_impact	0.39	0.9	5.26	8.17	0.52	P	0.79	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8730	8730	A	C	MI.433	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	204	68	W	C	tgA/tgC	7.3	1	0	probably_damaging	1	neutral	0.09	neutral	4.28	deleterious	-3.65	deleterious	-11.57	high_impact	3.6	0.45	damaging	0.24	damaging	3.94	23.50	deleterious	0.29	0.65	0.62	disease	0.9	disease	0.8	disease	0.84	disease	7	1	deleterious	0.05	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.28	medium_impact	1.99	medium_impact	0.24	0.9	49.56	8.58	0.57	P	1.00	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7052	7052	A	C	MI.4330	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1149	383	M	I	atA/atC	7.53	1	0	probably_damaging	0.96	deleterious	0	neutral	2.81	neutral	0.05	neutral	-2.05	high_impact	3.64	0.54	damaging	0.49	neutral	3.51	23.10	deleterious	0.41	0.55	0.29	neutral	0.93	disease	0.63	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-2.06	low_impact	-1.48	low_impact	2.26	high_impact	0.62	0.9	5.26	8.17	0.5	P	0.87	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7052	7052	A	T	MI.4331	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1149	383	M	I	atA/atT	7.53	1	0	probably_damaging	0.96	deleterious	0	neutral	2.81	neutral	0.05	neutral	-2.05	high_impact	3.64	0.54	damaging	0.49	neutral	3.68	23.30	deleterious	0.41	0.55	0.29	neutral	0.93	disease	0.63	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-2.06	low_impact	-1.48	low_impact	2.26	high_impact	0.62	0.9	5.26	8.17	0.52	P	0.87	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7053	7053	G	C	MI.4332	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1150	384	G	R	Gga/Cga	0.36	0.99	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.84	deleterious	-4.26	high_impact	5.05	0.49	damaging	0.03	damaging	3.99	23.60	deleterious	0.16	0.55	0.82	disease	0.94	disease	0.8	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.85	0.9	2.14	6.66	0.63	P	0.95	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7053	7053	G	T	MI.4333	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1150	384	G	W	Gga/Tga	0.36	0.99	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-5.31	deleterious	-4.26	high_impact	5.05	0.46	damaging	0.04	damaging	4.47	24.20	deleterious	0.13	0.55	0.96	disease	0.93	disease	0.74	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.40	0.9	2.14	6.66	0.61	P	0.83	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7054	7054	G	T	MI.4334	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1151	384	G	V	gGa/gTa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.62	neutral	-1.35	deleterious	-4.8	high_impact	5.05	0.52	damaging	0.04	damaging	3.86	23.50	deleterious	0.16	0.55	0.72	disease	0.94	disease	0.71	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.53	0.9	2.14	6.66	0.69	P	0.93	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7054	7054	G	A	MI.4335	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1151	384	G	E	gGa/gAa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.91	deleterious	-4.26	high_impact	5.05	0.43	damaging	0.03	damaging	3.98	23.60	deleterious	0.22	0.55	0.8	disease	0.91	disease	0.79	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.62	0.9	2.14	6.66	0.76	P	0.93	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7054	7054	G	C	MI.4336	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1151	384	G	A	gGa/gCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-0.26	deleterious	-3.2	high_impact	3.66	0.62	neutral	0.06	damaging	3.22	22.70	deleterious	0.21	0.55	0.25	neutral	0.78	disease	0.59	disease	0.63	disease	3	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	2.28	high_impact	0.70	0.9	2.14	6.66	0.42	N	0.64	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7056	7056	G	C	MI.4337	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1153	385	A	P	Gct/Cct	-4.73	0	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-3.8	deleterious	-2.6	high_impact	4.17	0.41	damaging	0.28	damaging	3.97	23.60	deleterious	0.14	0.55	0.69	disease	0.9	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.75	high_impact	0.81	0.9	3.31	6.67	0.51	P	0.85	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7056	7056	G	T	MI.4338	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1153	385	A	S	Gct/Tct	-4.73	0	0	probably_damaging	1	neutral	0.06	neutral	2.72	neutral	-0.89	neutral	-1.55	medium_impact	3.38	0.56	damaging	0.32	neutral	3.86	23.40	deleterious	0.33	0.55	0.36	neutral	0.87	disease	0.49	neutral	0.72	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.82	deleterious	-3.58	low_impact	-0.47	medium_impact	2.02	high_impact	0.76	0.9	3.31	6.67	0.34	N	0.64	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7056	7056	G	A	MI.4339	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1153	385	A	T	Gct/Act	-4.73	0	0	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-0.46	neutral	-2.06	high_impact	4.42	0.41	damaging	0.22	damaging	4.32	24.00	deleterious	0.44	0.55	0.22	neutral	0.88	disease	0.57	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.66	0.9	3.31	6.67	0.58	P	0.20	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8730	8730	A	T	MI.434	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	204	68	W	C	tgA/tgT	7.3	1	0	probably_damaging	1	neutral	0.09	neutral	4.28	deleterious	-3.65	deleterious	-11.57	high_impact	3.6	0.45	damaging	0.24	damaging	4.03	23.60	deleterious	0.29	0.65	0.62	disease	0.9	disease	0.8	disease	0.84	disease	7	1	deleterious	0.05	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-0.28	medium_impact	1.99	medium_impact	0.24	0.9	49.56	8.58	0.58	P	1.00	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7057	7057	C	T	MI.4340	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1154	385	A	V	gCt/gTt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.81	neutral	0	neutral	-2	medium_impact	2.79	0.42	damaging	0.18	damaging	4.42	24.20	deleterious	0.4	0.55	0.24	neutral	0.92	disease	0.5	neutral	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	1.48	medium_impact	0.73	0.9	3.31	6.67	0.6	P	0.75	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7057	7057	C	A	MI.4341	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1154	385	A	D	gCt/gAt	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-4.29	deleterious	-3.1	high_impact	4.97	0.45	damaging	0.3	neutral	4.60	24.40	deleterious	0.17	0.55	0.59	disease	0.94	disease	0.7	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.49	high_impact	0.66	0.9	3.31	6.67	0.71	P	0.89	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7057	7057	C	G	MI.4342	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1154	385	A	G	gCt/gGt	6.14	1	0	probably_damaging	0.99	deleterious	0	neutral	2.65	neutral	-2.5	neutral	-2.04	high_impact	4.08	0.47	damaging	0.39	neutral	4.03	23.70	deleterious	0.3	0.55	0.6	disease	0.85	disease	0.58	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.67	high_impact	0.78	0.9	3.31	6.67	0.57	P	0.56	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7059	7059	G	C	MI.4343	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1156	386	V	L	Gta/Cta	-7.74	0	0	probably_damaging	0.98	deleterious	0	neutral	2.68	neutral	-0.9	neutral	-1.56	medium_impact	3.48	0.69	neutral	0.05	damaging	3.68	23.30	deleterious	0.4	0.55	0.26	neutral	0.81	disease	0.4	neutral	0.63	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-2.35	low_impact	-1.48	low_impact	2.11	high_impact	0.75	0.9	2.34	6.59	0.3	N	0.55	polymorphism	0.95	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7059	7059	G	T	MI.4344	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1156	386	V	L	Gta/Tta	-7.74	0	0	probably_damaging	0.98	deleterious	0	neutral	2.68	neutral	-0.9	neutral	-1.56	medium_impact	3.48	0.69	neutral	0.05	damaging	3.78	23.40	deleterious	0.4	0.55	0.26	neutral	0.81	disease	0.4	neutral	0.63	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-2.35	low_impact	-1.48	low_impact	2.11	high_impact	0.75	0.9	2.34	6.59	0.3	N	0.55	polymorphism	0.95	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7059	7059	G	A	MI.4345	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1156	386	V	M	Gta/Ata	-7.74	0	0	probably_damaging	1	deleterious	0	neutral	2.54	deleterious	-3.18	neutral	-1.57	high_impact	4.08	0.7	neutral	0.07	damaging	3.81	23.40	deleterious	0.36	0.55	0.48	neutral	0.81	disease	0.53	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.67	high_impact	0.79	0.9	2.34	6.59	0.27	N	0.82	polymorphism	0.94	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7060	7060	T	A	MI.4346	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1157	386	V	E	gTa/gAa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.52	deleterious	-4.53	deleterious	-3.18	high_impact	4.63	0.67	neutral	0.08	damaging	4.71	24.60	deleterious	0.12	0.55	0.33	neutral	0.91	disease	0.73	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.18	high_impact	0.58	0.9	2.34	6.59	0.5	N	0.84	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7060	7060	T	C	MI.4347	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1157	386	V	A	gTa/gCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.68	neutral	-1.47	neutral	-2.12	high_impact	3.83	0.68	neutral	0.1	damaging	3.61	23.20	deleterious	0.33	0.55	0.43	neutral	0.71	disease	0.59	disease	0.6	disease	2	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.44	high_impact	0.40	0.9	2.34	6.59	0.49	P	0.47	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7060	7060	T	G	MI.4348	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1157	386	V	G	gTa/gGa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-4.09	deleterious	-3.71	high_impact	4.08	0.66	neutral	0.1	damaging	3.88	23.50	deleterious	0.16	0.55	0.74	disease	0.86	disease	0.61	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.67	high_impact	0.54	0.9	2.34	6.59	0.44	N	0.71	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7062	7062	T	A	MI.4349	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1159	387	F	I	Ttt/Att	-10.75	0	0	probably_damaging	1	deleterious	0	neutral	2.62	neutral	-1.34	deleterious	-3.17	medium_impact	3.09	0.74	neutral	0.08	damaging	4.44	24.20	deleterious	0.2	0.55	0.34	neutral	0.93	disease	0.64	disease	0.76	disease	5	1	deleterious	0	neutral	5	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	1.75	medium_impact	0.64	0.9	3.7	8.35	0.27	N	0.88	polymorphism	0.76	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8731	8731	T	G	MI.435	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	205	69	S	A	Tct/Gct	1.75	0.85	0	probably_damaging	0.97	neutral	1	neutral	4.45	neutral	0.64	neutral	0.03	neutral_impact	-1.31	0.87	neutral	0.96	neutral	0.83	9.67	deleterious	0.49	0.65	0.27	neutral	0.13	neutral	0.28	neutral	0.22	neutral	6	0.97	neutral	0.52	deleterious	-2	neutral	0.66	deleterious	-2.19	low_impact	1.98	high_impact	-2.22	low_impact	0.80	0.9	12.39	14.86	0.29	N	0.03	polymorphism	0.97	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7062	7062	T	G	MI.4350	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1159	387	F	V	Ttt/Gtt	-10.75	0	0	probably_damaging	1	deleterious	0	neutral	2.6	neutral	-1.56	deleterious	-3.7	high_impact	4.07	0.72	neutral	0.07	damaging	4.05	23.70	deleterious	0.2	0.55	0.39	neutral	0.94	disease	0.65	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.66	high_impact	0.58	0.9	3.7	8.35	0.32	N	0.84	polymorphism	0.6	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7062	7062	T	C	MI.4351	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1159	387	F	L	Ttt/Ctt	-10.75	0	0	probably_damaging	0.99	deleterious	0	neutral	2.72	neutral	-0.48	deleterious	-3.17	high_impact	4	0.76	neutral	0.08	damaging	4.07	23.70	deleterious	0.29	0.55	0.26	neutral	0.88	disease	0.61	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.59	high_impact	0.68	0.9	3.7	8.35	0.29	N	0.83	polymorphism	0.74	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7063	7063	T	C	MI.4352	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1160	387	F	S	tTt/tCt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.53	neutral	-2.74	deleterious	-4.23	high_impact	3.85	0.76	neutral	0.08	damaging	4.37	24.10	deleterious	0.14	0.55	0.58	disease	0.9	disease	0.64	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.46	high_impact	0.53	0.9	3.7	8.35	0.46	N	0.84	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7063	7063	T	A	MI.4353	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1160	387	F	Y	tTt/tAt	5.91	1	0	probably_damaging	0.99	deleterious	0.04	neutral	2.58	neutral	-1.81	neutral	-1.58	high_impact	3.65	0.73	neutral	0.06	damaging	4.37	24.10	deleterious	0.23	0.55	0.66	disease	0.87	disease	0.49	neutral	0.53	disease	1	1	deleterious	0.03	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-0.58	medium_impact	2.27	high_impact	0.70	0.9	3.7	8.35	0.53	P	0.59	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7063	7063	T	G	MI.4354	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1160	387	F	C	tTt/tGt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-3.84	deleterious	-4.23	high_impact	5.04	0.74	neutral	0.06	damaging	4.22	23.90	deleterious	0.17	0.55	0.76	disease	0.92	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.40	0.9	3.7	8.35	0.68	P	0.91	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7064	7064	T	G	MI.4355	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1161	387	F	L	ttT/ttG	4.76	1	0	probably_damaging	0.99	deleterious	0	neutral	2.72	neutral	-0.48	deleterious	-3.17	high_impact	4	0.76	neutral	0.08	damaging	4.39	24.10	deleterious	0.29	0.55	0.26	neutral	0.88	disease	0.61	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.59	high_impact	0.68	0.9	3.7	8.35	0.5	N	0.83	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7064	7064	T	A	MI.4356	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1161	387	F	L	ttT/ttA	4.76	1	0	probably_damaging	0.99	deleterious	0	neutral	2.72	neutral	-0.48	deleterious	-3.17	high_impact	4	0.76	neutral	0.08	damaging	4.53	24.30	deleterious	0.29	0.55	0.26	neutral	0.88	disease	0.61	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-1.48	low_impact	2.59	high_impact	0.68	0.9	3.7	8.35	0.51	P	0.83	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7065	7065	G	A	MI.4357	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1162	388	A	T	Gcc/Acc	-7.97	0	0	probably_damaging	1	neutral	0.06	neutral	2.59	neutral	-1.83	neutral	-1.92	medium_impact	2.46	0.56	damaging	0.08	damaging	4.34	24.10	deleterious	0.39	0.55	0.57	disease	0.83	disease	0.33	neutral	0.53	disease	1	1	deleterious	0.03	neutral	1	deleterious	0.83	deleterious	-3.58	low_impact	-0.47	medium_impact	1.17	medium_impact	0.84	0.9	4.09	8.05	0.27	N	0.20	polymorphism	0.72	0.04	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7065	7065	G	C	MI.4358	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1162	388	A	P	Gcc/Ccc	-7.97	0	0	probably_damaging	1	deleterious	0	neutral	2.54	neutral	-2.91	neutral	-2.44	high_impact	4	0.53	damaging	0.05	damaging	3.93	23.50	deleterious	0.09	0.55	0.55	disease	0.93	disease	0.65	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	2.59	high_impact	0.83	0.9	4.09	8.05	0.3	N	0.85	disease_causing	0.58	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7065	7065	G	T	MI.4359	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1162	388	A	S	Gcc/Tcc	-7.97	0	0	probably_damaging	1	neutral	0.09	neutral	2.57	neutral	-2.09	neutral	-1.36	medium_impact	1.98	0.54	damaging	0.07	damaging	3.81	23.40	deleterious	0.27	0.55	0.49	neutral	0.78	disease	0.29	neutral	0.5	disease	0	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-3.58	low_impact	-0.37	medium_impact	0.73	medium_impact	0.81	0.9	4.09	8.05	0.27	N	0.64	polymorphism	0.85	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8731	8731	T	A	MI.436	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	205	69	S	T	Tct/Act	1.75	0.85	0	probably_damaging	0.98	neutral	0.62	neutral	4.34	neutral	0.65	neutral	-1.21	neutral_impact	-0.53	0.9	neutral	0.9	neutral	2.44	19.09	deleterious	0.36	0.65	0.58	disease	0.42	neutral	0.34	neutral	0.61	disease	2	0.98	neutral	0.32	neutral	-2	neutral	0.75	deleterious	-2.36	low_impact	0.41	medium_impact	-1.55	low_impact	0.84	0.9	12.39	14.86	0.3	N	0.02	polymorphism	0.91	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7066	7066	C	G	MI.4360	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1163	388	A	G	gCc/gGc	7.3	1	0	probably_damaging	0.99	neutral	0.3	neutral	2.67	neutral	-0.89	neutral	-1.57	low_impact	1.84	0.46	damaging	0.06	damaging	3.00	22.20	deleterious	0.22	0.55	0.19	neutral	0.74	disease	0.27	neutral	0.47	neutral	1	0.99	deleterious	0.16	neutral	-2	neutral	0.72	deleterious	-2.64	low_impact	-0.01	medium_impact	0.6	medium_impact	0.85	0.9	4.09	8.05	0.51	P	0.56	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7066	7066	C	T	MI.4361	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1163	388	A	V	gCc/gTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-1.17	neutral	-2.03	high_impact	4	0.55	damaging	0.06	damaging	4.59	24.40	deleterious	0.28	0.55	0.41	neutral	0.92	disease	0.53	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.59	high_impact	0.81	0.9	4.09	8.05	0.5	P	0.75	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7066	7066	C	A	MI.4362	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1163	388	A	D	gCc/gAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.51	deleterious	-4.56	deleterious	-2.85	high_impact	4.8	0.53	damaging	0.05	damaging	4.59	24.40	deleterious	0.1	0.55	0.75	disease	0.95	disease	0.64	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.33	high_impact	0.80	0.9	4.09	8.05	0.66	P	0.89	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7068	7068	A	C	MI.4363	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1165	389	I	L	Atc/Ctc	-8.89	0	0	probably_damaging	0.98	deleterious	0.04	neutral	2.9	neutral	0.32	neutral	-0.99	low_impact	1.75	0.55	damaging	0.54	neutral	2.79	21.30	deleterious	0.33	0.55	0.22	neutral	0.5	neutral	0.29	neutral	0.42	neutral	2	1	deleterious	0.03	neutral	2	deleterious	0.63	deleterious	-2.35	low_impact	-0.58	medium_impact	0.52	medium_impact	0.81	0.9	7.6	8.19	0.49	N	0.61	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7068	7068	A	G	MI.4364	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1165	389	I	V	Atc/Gtc	-8.89	0	0	probably_damaging	0.95	neutral	0.06	neutral	2.82	neutral	-0.38	neutral	-0.53	medium_impact	3.08	0.57	damaging	0.36	neutral	3.15	22.60	deleterious	0.5	0.55	0.3	neutral	0.51	disease	0.35	neutral	0.45	neutral	1	0.99	deleterious	0.06	neutral	1	deleterious	0.62	deleterious	-1.96	low_impact	-0.47	medium_impact	1.75	medium_impact	0.71	0.9	7.6	8.19	0.46	N	0.23	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7068	7068	A	T	MI.4365	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1165	389	I	F	Atc/Ttc	-8.89	0	0	probably_damaging	1	deleterious	0.01	neutral	2.83	neutral	-0.29	neutral	-2.08	high_impact	3.92	0.54	damaging	0.31	neutral	4.00	23.60	deleterious	0.25	0.55	0.33	neutral	0.83	disease	0.47	neutral	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-0.92	medium_impact	2.52	high_impact	0.78	0.9	7.6	8.19	0.36	N	0.85	disease_causing	0.74	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7069	7069	T	C	MI.4366	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1166	389	I	T	aTc/aCc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-1.35	deleterious	-2.61	medium_impact	3.27	0.61	neutral	0.34	neutral	3.54	23.10	deleterious	0.3	0.55	0.47	neutral	0.74	disease	0.53	disease	0.58	disease	2	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	1.92	medium_impact	0.63	0.9	7.6	8.19	0.46	P	0.76	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7069	7069	T	A	MI.4367	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1166	389	I	N	aTc/aAc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.69	deleterious	-3.6	deleterious	-3.67	high_impact	4.46	0.55	damaging	0.36	neutral	4.50	24.30	deleterious	0.19	0.55	0.69	disease	0.83	disease	0.56	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.66	0.9	7.6	8.19	0.5	P	0.94	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7069	7069	T	G	MI.4368	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1166	389	I	S	aTc/aGc	7.07	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.25	deleterious	-3.14	high_impact	3.57	0.67	neutral	0.42	neutral	4.41	24.10	deleterious	0.2	0.55	0.52	disease	0.83	disease	0.56	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	2.2	high_impact	0.56	0.9	7.6	8.19	0.46	N	0.62	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7070	7070	C	A	MI.4369	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1167	389	I	M	atC/atA	5.91	1	0	probably_damaging	1	deleterious	0.01	neutral	2.72	neutral	-1	neutral	-1.53	medium_impact	2.58	0.58	damaging	0.5	neutral	3.94	23.60	deleterious	0.33	0.55	0.32	neutral	0.54	disease	0.3	neutral	0.43	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.68	deleterious	-3.58	low_impact	-0.92	medium_impact	1.28	medium_impact	0.80	0.9	7.6	8.19	0.49	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8731	8731	T	C	MI.437	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	205	69	S	P	Tct/Cct	1.75	0.85	0	probably_damaging	0.99	neutral	0.11	neutral	4.29	neutral	-1.54	deleterious	-3.03	low_impact	0.95	0.71	neutral	0.14	damaging	3.84	23.40	deleterious	0.18	0.65	0.84	disease	0.92	disease	0.71	disease	0.82	disease	6	1	deleterious	0.06	neutral	-2	neutral	0.91	deleterious	-2.65	low_impact	-0.22	medium_impact	-0.28	medium_impact	0.81	0.9	12.39	14.86	0.24	N	0.78	polymorphism	0.61	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7070	7070	C	G	MI.4370	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1167	389	I	M	atC/atG	5.91	1	0	probably_damaging	1	deleterious	0.01	neutral	2.72	neutral	-1	neutral	-1.53	medium_impact	2.58	0.58	damaging	0.5	neutral	3.42	23.00	deleterious	0.33	0.55	0.32	neutral	0.54	disease	0.3	neutral	0.43	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.68	deleterious	-3.58	low_impact	-0.92	medium_impact	1.28	medium_impact	0.80	0.9	7.6	8.19	0.49	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7071	7071	A	C	MI.4371	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1168	390	M	L	Ata/Cta	-4.04	0	0	possibly_damaging	0.84	neutral	0.22	neutral	2.91	neutral	0.33	neutral	-0.45	low_impact	0.86	0.69	neutral	0.38	neutral	2.07	16.64	deleterious	0.31	0.55	0.18	neutral	0.72	disease	0.37	neutral	0.51	disease	0	0.89	neutral	0.19	neutral	-3	neutral	0.56	deleterious	-1.43	low_impact	-0.11	medium_impact	-0.31	medium_impact	0.46	0.9	9.94	14.87	0.34	N	0.61	polymorphism	0.74	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7071	7071	A	G	MI.4372	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1168	390	M	V	Ata/Gta	-4.04	0	0	possibly_damaging	0.89	neutral	0.19	neutral	2.76	neutral	-0.28	neutral	-1.09	medium_impact	2.23	0.69	neutral	0.26	damaging	2.87	21.70	deleterious	0.32	0.55	0.22	neutral	0.87	disease	0.43	neutral	0.69	disease	4	0.94	neutral	0.15	neutral	0	NA	0.67	deleterious	-1.61	low_impact	-0.16	medium_impact	0.96	medium_impact	0.51	0.9	9.94	14.87	0.33	N	0.88	polymorphism	0.7	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7071	7071	A	T	MI.4373	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1168	390	M	L	Ata/Tta	-4.04	0	0	possibly_damaging	0.84	neutral	0.22	neutral	2.91	neutral	0.33	neutral	-0.45	low_impact	0.86	0.69	neutral	0.38	neutral	2.14	17.10	deleterious	0.31	0.55	0.18	neutral	0.72	disease	0.37	neutral	0.51	disease	0	0.89	neutral	0.19	neutral	-3	neutral	0.56	deleterious	-1.43	low_impact	-0.11	medium_impact	-0.31	medium_impact	0.46	0.9	9.94	14.87	0.34	N	0.61	polymorphism	0.74	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7072	7072	T	A	MI.4374	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1169	390	M	K	aTa/aAa	2.67	0.98	0	probably_damaging	0.95	deleterious	0	neutral	2.63	neutral	-2.75	deleterious	-2.51	high_impact	3.82	0.65	neutral	0.11	damaging	4.07	23.70	deleterious	0.16	0.55	0.56	disease	0.94	disease	0.69	disease	0.83	disease	6	1	deleterious	0.03	neutral	6	deleterious	0.83	deleterious	-1.96	low_impact	-1.48	low_impact	2.43	high_impact	0.55	0.9	9.94	14.87	0.43	N	0.93	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7072	7072	T	C	MI.4375	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1169	390	M	T	aTa/aCa	2.67	0.98	0	probably_damaging	0.98	deleterious	0	neutral	2.68	neutral	-0.83	neutral	-2.17	medium_impact	3.27	0.66	neutral	0.17	damaging	3.09	22.50	deleterious	0.28	0.55	0.39	neutral	0.85	disease	0.62	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-2.35	low_impact	-1.48	low_impact	1.92	medium_impact	0.51	0.9	9.94	14.87	0.4	N	0.79	disease_causing	0.99	0.05	.	.	.	.	.	.	COSM1138400	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7073	7073	A	C	MI.4376	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1170	390	M	I	atA/atC	5.91	0.99	0	probably_damaging	0.92	neutral	0.32	neutral	2.77	neutral	-0.14	neutral	-0.81	neutral_impact	0.66	0.68	neutral	0.6	neutral	2.38	18.66	deleterious	0.31	0.55	0.29	neutral	0.85	disease	0.38	neutral	0.53	disease	1	0.93	neutral	0.2	neutral	-2	neutral	0.71	deleterious	-1.76	low_impact	0.01	medium_impact	-0.49	medium_impact	0.55	0.9	9.94	14.87	0.47	N	0.87	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7073	7073	A	T	MI.4377	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1170	390	M	I	atA/atT	5.91	0.99	0	probably_damaging	0.92	neutral	0.32	neutral	2.77	neutral	-0.14	neutral	-0.81	neutral_impact	0.66	0.68	neutral	0.6	neutral	2.50	19.49	deleterious	0.31	0.55	0.29	neutral	0.85	disease	0.38	neutral	0.53	disease	1	0.93	neutral	0.2	neutral	-2	neutral	0.71	deleterious	-1.76	low_impact	0.01	medium_impact	-0.49	medium_impact	0.55	0.9	9.94	14.87	0.49	N	0.87	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7074	7074	G	T	MI.4378	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1171	391	G	W	Gga/Tga	-1.03	0.01	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-7.5	neutral	-2.2	high_impact	3.81	0.68	neutral	0.31	neutral	4.48	24.20	deleterious	0.12	0.55	0.94	disease	0.93	disease	0.58	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.42	high_impact	0.52	0.9	7.41	38.69	0.32	N	0.71	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7074	7074	G	C	MI.4379	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1171	391	G	R	Gga/Cga	-1.03	0.01	0	probably_damaging	1	deleterious	0.01	neutral	2.47	deleterious	-5.59	neutral	-1.45	medium_impact	3.25	0.63	neutral	0.28	damaging	4.00	23.60	deleterious	0.1	0.55	0.73	disease	0.95	disease	0.69	disease	0.84	disease	7	1	deleterious	0.01	neutral	5	deleterious	0.89	deleterious	-3.58	low_impact	-0.92	medium_impact	1.9	medium_impact	0.65	0.9	7.41	38.69	0.28	N	0.70	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8732	8732	C	A	MI.438	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	206	69	S	Y	tCt/tAt	-0.57	0.15	0	probably_damaging	1	neutral	0.28	neutral	4.28	neutral	-1.05	deleterious	-3.9	low_impact	1.23	0.88	neutral	0.19	damaging	4.00	23.60	deleterious	0.21	0.65	0.53	disease	0.85	disease	0.64	disease	0.78	disease	6	1	deleterious	0.14	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.06	medium_impact	-0.04	medium_impact	0.75	0.9	12.39	14.86	0.35	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7075	7075	G	T	MI.4380	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1172	391	G	V	gGa/gTa	6.14	0.99	0	probably_damaging	1	deleterious	0.01	neutral	2.5	deleterious	-4.09	neutral	-1.23	medium_impact	3	0.71	neutral	0.47	neutral	3.81	23.40	deleterious	0.14	0.55	0.61	disease	0.91	disease	0.57	disease	0.78	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-0.92	medium_impact	1.67	medium_impact	0.66	0.9	7.41	38.69	0.45	N	0.61	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7075	7075	G	C	MI.4381	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1172	391	G	A	gGa/gCa	6.14	0.99	0	probably_damaging	1	neutral	0.89	neutral	3.16	neutral	0.47	neutral	0.62	neutral_impact	-0.8	0.7	neutral	0.89	neutral	0.49	7.37	deleterious	0.22	0.55	0.27	neutral	0.17	neutral	0.2	neutral	0.28	neutral	4	1	deleterious	0.45	neutral	-2	neutral	0.65	deleterious	-3.58	low_impact	0.7	medium_impact	-1.84	low_impact	0.58	0.9	7.41	38.69	0.49	N	0.01	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7075	7075	G	A	MI.4382	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1172	391	G	E	gGa/gAa	6.14	0.99	0	probably_damaging	1	deleterious	0.01	neutral	2.47	deleterious	-5.43	neutral	-1.43	high_impact	3.81	0.64	neutral	0.35	neutral	3.99	23.60	deleterious	0.13	0.55	0.71	disease	0.91	disease	0.68	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.92	medium_impact	2.42	high_impact	0.60	0.9	7.41	38.69	0.49	N	0.84	polymorphism	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7077	7077	G	A	MI.4383	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1174	392	G	S	Ggc/Agc	-9.13	0	0	probably_damaging	1	neutral	0.16	neutral	2.64	neutral	-2.78	neutral	-2.48	low_impact	1.87	0.65	neutral	0.62	neutral	3.17	22.70	deleterious	0.28	0.55	0.32	neutral	0.71	disease	0.47	neutral	0.5	disease	0	1	deleterious	0.08	neutral	-2	neutral	0.74	deleterious	-3.58	low_impact	-0.21	medium_impact	0.63	medium_impact	0.73	0.9	2.92	7.5	0.37	N	0.73	polymorphism	0.8	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7077	7077	G	T	MI.4384	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1174	392	G	C	Ggc/Tgc	-9.13	0	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-4.85	deleterious	-4.11	high_impact	4.91	0.59	damaging	0.26	damaging	4.30	24.00	deleterious	0.16	0.55	0.88	disease	0.94	disease	0.67	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.68	0.9	2.92	7.5	0.64	P	0.98	disease_causing	0.51	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7077	7077	G	C	MI.4385	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1174	392	G	R	Ggc/Cgc	-9.13	0	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.85	deleterious	-3.69	high_impact	4.55	0.62	neutral	0.23	damaging	4.07	23.70	deleterious	0.11	0.55	0.84	disease	0.95	disease	0.77	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.59	0.9	2.92	7.5	0.48	N	0.95	polymorphism	0.65	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7078	7078	G	C	MI.4386	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1175	392	G	A	gGc/gCc	7.53	1	0	probably_damaging	1	neutral	0.15	neutral	2.86	neutral	-0.91	deleterious	-2.55	medium_impact	2.4	0.62	neutral	0.61	neutral	2.01	16.26	deleterious	0.36	0.55	0.4	neutral	0.67	disease	0.45	neutral	0.47	neutral	1	1	deleterious	0.08	neutral	1	deleterious	0.75	deleterious	-3.58	low_impact	-0.23	medium_impact	1.12	medium_impact	0.76	0.9	2.92	7.5	0.51	P	0.64	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7078	7078	G	A	MI.4387	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1175	392	G	D	gGc/gAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-4.5	deleterious	-3.21	high_impact	4.91	0.6	damaging	0.28	damaging	3.93	23.50	deleterious	0.12	0.55	0.84	disease	0.91	disease	0.76	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.55	0.9	2.92	7.5	0.72	P	0.97	disease_causing	1	0.37	.	.	.	.	.	.	COSM1155670	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7078	7078	G	T	MI.4388	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1175	392	G	V	gGc/gTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.69	neutral	-1.64	deleterious	-4.16	high_impact	4.55	0.69	neutral	0.33	neutral	3.85	23.40	deleterious	0.13	0.55	0.76	disease	0.93	disease	0.68	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.1	high_impact	0.69	0.9	2.92	7.5	0.53	P	0.93	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7080	7080	T	G	MI.4389	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1177	393	F	V	Ttc/Gtc	-10.05	0	0	probably_damaging	1	neutral	0.12	neutral	2.85	neutral	0.43	neutral	-1.46	low_impact	1.36	0.61	neutral	0.62	neutral	2.78	21.30	deleterious	0.32	0.55	0.24	neutral	0.87	disease	0.43	neutral	0.52	disease	0	1	deleterious	0.06	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.29	medium_impact	0.16	medium_impact	0.61	0.9	6.43	9.35	0.42	N	0.84	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8732	8732	C	G	MI.439	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	206	69	S	C	tCt/tGt	-0.57	0.15	0	probably_damaging	1	neutral	0.11	neutral	4.27	neutral	-2.2	deleterious	-2.61	low_impact	1.92	0.87	neutral	0.2	damaging	3.43	23.00	deleterious	0.27	0.65	0.82	disease	0.81	disease	0.43	neutral	0.74	disease	5	1	deleterious	0.06	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	-0.22	medium_impact	0.55	medium_impact	0.77	0.9	12.39	14.86	0.34	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7080	7080	T	C	MI.4390	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1177	393	F	L	Ttc/Ctc	-10.05	0	0	probably_damaging	0.99	neutral	0.16	neutral	2.9	neutral	0.79	neutral	-1.12	low_impact	0.96	0.61	neutral	0.71	neutral	0.89	9.99	deleterious	0.38	0.55	0.28	neutral	0.66	disease	0.39	neutral	0.48	neutral	0	1	deleterious	0.09	neutral	-2	neutral	0.70	deleterious	-2.64	low_impact	-0.21	medium_impact	-0.21	medium_impact	0.66	0.9	6.43	9.35	0.43	N	0.83	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	1.19	T7080C	Prostate Cancer	+	-	Reported	1	.	P	P	neutral
chrM	7080	7080	T	A	MI.4391	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1177	393	F	I	Ttc/Atc	-10.05	0	0	probably_damaging	1	neutral	0.22	neutral	3.02	neutral	1.42	neutral	-1.04	low_impact	1.02	0.58	damaging	0.75	neutral	1.51	13.37	neutral	0.22	0.55	0.34	neutral	0.76	disease	0.38	neutral	0.52	disease	0	1	deleterious	0.11	neutral	-2	neutral	0.73	deleterious	-3.58	low_impact	-0.11	medium_impact	-0.16	medium_impact	0.61	0.9	6.43	9.35	0.43	N	0.88	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7081	7081	T	G	MI.4392	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1178	393	F	C	tTc/tGc	3.14	0.99	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.1	neutral	-2.45	high_impact	4.04	0.6	damaging	0.51	neutral	4.19	23.80	deleterious	0.25	0.55	0.73	disease	0.91	disease	0.61	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.63	high_impact	0.41	0.9	6.43	9.35	0.41	N	0.91	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7081	7081	T	A	MI.4393	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1178	393	F	Y	tTc/tAc	3.14	0.99	0	probably_damaging	0.99	neutral	0.07	neutral	2.73	neutral	-1.09	neutral	-1.05	medium_impact	2.9	0.66	neutral	0.5	neutral	4.04	23.70	deleterious	0.31	0.55	0.53	disease	0.81	disease	0.4	neutral	0.53	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-2.64	low_impact	-0.43	medium_impact	1.58	medium_impact	0.65	0.9	6.43	9.35	0.52	P	0.59	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7081	7081	T	C	MI.4394	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1178	393	F	S	tTc/tCc	3.14	0.99	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-1.66	deleterious	-2.6	high_impact	3.68	0.71	neutral	0.58	neutral	4.29	24.00	deleterious	0.32	0.55	0.4	neutral	0.84	disease	0.59	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.3	high_impact	0.55	0.9	6.43	9.35	0.44	N	0.84	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7082	7082	C	A	MI.4395	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1179	393	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.99	neutral	0.16	neutral	2.9	neutral	0.79	neutral	-1.12	low_impact	0.96	0.61	neutral	0.71	neutral	1.48	13.20	neutral	0.38	0.55	0.28	neutral	0.66	disease	0.39	neutral	0.48	neutral	0	1	deleterious	0.09	neutral	-2	neutral	0.70	deleterious	-2.64	low_impact	-0.21	medium_impact	-0.21	medium_impact	0.66	0.9	6.43	9.35	0.6	P	0.83	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7082	7082	C	G	MI.4396	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1179	393	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.99	neutral	0.16	neutral	2.9	neutral	0.79	neutral	-1.12	low_impact	0.96	0.61	neutral	0.71	neutral	1.12	11.31	neutral	0.38	0.55	0.28	neutral	0.66	disease	0.39	neutral	0.48	neutral	0	1	deleterious	0.09	neutral	-2	neutral	0.70	deleterious	-2.64	low_impact	-0.21	medium_impact	-0.21	medium_impact	0.66	0.9	6.43	9.35	0.56	P	0.83	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7083	7083	A	T	MI.4397	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1180	394	I	F	Att/Ttt	-3.11	0	0	benign	0.22	deleterious	0.03	neutral	2.8	neutral	-0.16	neutral	-1.48	medium_impact	2.08	0.61	neutral	0.46	neutral	0.99	10.61	neutral	0.44	0.55	0.33	neutral	0.8	disease	0.3	neutral	0.66	disease	3	0.97	neutral	0.41	neutral	1	deleterious	0.30	neutral	-0.24	medium_impact	-0.65	medium_impact	0.82	medium_impact	0.65	0.9	13.65	40.83	0.41	N	0.37	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7083	7083	A	C	MI.4398	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1180	394	I	L	Att/Ctt	-3.11	0	0	benign	0.01	neutral	0.07	neutral	2.89	neutral	0.88	neutral	-0.66	medium_impact	2	0.72	neutral	0.51	neutral	0.88	9.96	deleterious	0.35	0.55	0.19	neutral	0.64	disease	0.38	neutral	0.51	disease	0	0.93	neutral	0.53	deleterious	-3	neutral	0.11	neutral	1.12	medium_impact	-0.43	medium_impact	0.75	medium_impact	0.55	0.9	13.65	40.83	0.46	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7083	7083	A	G	MI.4399	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1180	394	I	V	Att/Gtt	-3.11	0	0	benign	0	neutral	1	neutral	2.81	neutral	0	neutral	0.06	low_impact	1.04	0.86	neutral	0.99	neutral	-1.16	0.01	neutral	0.57	0.6	0.19	neutral	0.21	neutral	0.29	neutral	0.36	neutral	3	0	neutral	1	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	1.86	high_impact	-0.14	medium_impact	0.65	0.9	13.65	40.83	0.41	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	75.22	A7083G	Prostate Cancer	+	-	Reported	1	.	P	P	neutral
chrM	8545	8545	G	A	MI.44	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	19	7	A	T	Gct/Act	-1.03	0	0.01	benign	0	neutral	0.07	neutral	4.67	neutral	-0.68	neutral	0.22	low_impact	0.8	1	neutral	0.96	neutral	0.75	9.13	deleterious	0.54	0.65	0.41	neutral	0.32	neutral	0.26	neutral	0.47	neutral	1	0.93	neutral	0.54	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	-0.34	medium_impact	-0.41	medium_impact	0.61	0.9	9.29	10.06	0.51	P	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8732	8732	C	T	MI.440	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	206	69	S	F	tCt/tTt	-0.57	0.15	0	probably_damaging	1	neutral	0.41	neutral	4.38	neutral	1.32	deleterious	-3.9	neutral_impact	-0.04	0.77	neutral	0.16	damaging	4.02	23.60	deleterious	0.28	0.65	0.3	neutral	0.84	disease	0.62	disease	0.59	disease	2	1	deleterious	0.21	neutral	-2	neutral	0.76	deleterious	-3.6	low_impact	0.2	medium_impact	-1.13	low_impact	0.64	0.9	12.39	14.86	0.25	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7084	7084	T	G	MI.4400	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1181	394	I	S	aTt/aGt	1.05	0.46	0	benign	0.09	neutral	0.12	neutral	2.8	neutral	-0.15	neutral	-1.44	medium_impact	2.22	0.62	neutral	0.55	neutral	1.44	13.02	neutral	0.33	0.55	0.34	neutral	0.75	disease	0.45	neutral	0.54	disease	1	0.87	neutral	0.52	deleterious	-3	neutral	0.20	neutral	0.19	medium_impact	-0.29	medium_impact	0.95	medium_impact	0.63	0.9	13.65	40.83	0.38	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7084	7084	T	A	MI.4401	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1181	394	I	N	aTt/aAt	1.05	0.46	0	possibly_damaging	0.46	neutral	0.1	neutral	2.72	neutral	-2.08	neutral	-1.95	low_impact	1.92	0.71	neutral	0.61	neutral	1.47	13.17	neutral	0.36	0.55	0.59	disease	0.79	disease	0.32	neutral	0.55	disease	1	0.89	neutral	0.32	neutral	-3	neutral	0.54	deleterious	-0.69	medium_impact	-0.34	medium_impact	0.67	medium_impact	0.70	0.9	13.65	40.83	0.33	N	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7084	7084	T	C	MI.4402	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1181	394	I	T	aTt/aCt	1.05	0.46	0	benign	0.09	neutral	0.48	neutral	2.78	neutral	-0.36	neutral	-0.55	low_impact	1.06	0.72	neutral	0.92	neutral	-0.74	0.06	neutral	0.43	0.55	0.25	neutral	0.44	neutral	0.31	neutral	0.45	neutral	1	0.45	neutral	0.7	deleterious	-6	neutral	0.16	neutral	0.19	medium_impact	0.17	medium_impact	-0.12	medium_impact	0.68	0.9	13.65	40.83	0.34	N	0.25	polymorphism	1	0.02	rs28445709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7085	7085	T	G	MI.4403	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1182	394	I	M	atT/atG	2.9	0.52	0.01	benign	0.02	deleterious	0.02	neutral	2.74	neutral	-1.45	neutral	-0.84	medium_impact	3.12	0.73	neutral	0.81	neutral	1.54	13.51	neutral	0.48	0.55	0.42	neutral	0.49	neutral	0.31	neutral	0.5	disease	0	0.98	neutral	0.5	deleterious	1	deleterious	0.13	neutral	0.83	medium_impact	-0.75	medium_impact	1.78	medium_impact	0.76	0.9	13.65	40.83	0.44	N	0.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7085	7085	T	A	MI.4404	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1182	394	I	M	atT/atA	2.9	0.52	0.01	benign	0.02	deleterious	0.02	neutral	2.74	neutral	-1.45	neutral	-0.84	medium_impact	3.12	0.73	neutral	0.81	neutral	1.80	15.01	deleterious	0.48	0.55	0.42	neutral	0.49	neutral	0.31	neutral	0.5	disease	0	0.98	neutral	0.5	deleterious	1	deleterious	0.13	neutral	0.83	medium_impact	-0.75	medium_impact	1.78	medium_impact	0.76	0.9	13.65	40.83	0.45	N	0.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7086	7086	C	A	MI.4405	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1183	395	H	N	Cac/Aac	-8.89	0	0	probably_damaging	1	deleterious	0.04	neutral	2.76	neutral	-1.71	deleterious	-2.69	medium_impact	2.36	0.54	damaging	0.07	damaging	2.89	21.80	deleterious	0.54	0.6	0.87	disease	0.86	disease	0.52	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-3.58	low_impact	-0.58	medium_impact	1.08	medium_impact	0.58	0.9	2.34	6.69	0.22	N	0.86	polymorphism	0.94	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7086	7086	C	T	MI.4406	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1183	395	H	Y	Cac/Tac	-8.89	0	0	probably_damaging	1	neutral	0.25	neutral	3.1	neutral	2.54	neutral	-1.19	neutral_impact	0.72	0.43	damaging	0.04	damaging	2.56	19.84	deleterious	0.62	0.65	0.16	neutral	0.61	disease	0.41	neutral	0.42	neutral	2	1	deleterious	0.13	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.07	medium_impact	-0.43	medium_impact	0.35	0.9	2.34	6.69	0.31	N	0.72	polymorphism	0.93	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7086	7086	C	G	MI.4407	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1183	395	H	D	Cac/Gac	-8.89	0	0	probably_damaging	1	deleterious	0.01	neutral	2.79	neutral	-0.52	deleterious	-3.48	high_impact	4.31	0.5	damaging	0.04	damaging	3.97	23.60	deleterious	0.26	0.55	0.93	disease	0.89	disease	0.73	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-0.92	medium_impact	2.88	high_impact	0.57	0.9	2.34	6.69	0.35	N	0.97	polymorphism	0.83	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7087	7087	A	T	MI.4408	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1184	395	H	L	cAc/cTc	7.3	1	0	probably_damaging	1	neutral	0.27	neutral	2.9	neutral	1.3	deleterious	-3.97	medium_impact	2.89	0.53	damaging	0.03	damaging	3.89	23.50	deleterious	0.35	0.55	0.58	disease	0.91	disease	0.51	disease	0.55	disease	1	1	deleterious	0.14	neutral	1	deleterious	0.84	deleterious	-3.58	low_impact	-0.05	medium_impact	1.57	medium_impact	0.46	0.9	2.34	6.69	0.47	N	0.92	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7087	7087	A	C	MI.4409	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1184	395	H	P	cAc/cCc	7.3	1	0	probably_damaging	1	deleterious	0.01	neutral	2.75	neutral	-2.23	deleterious	-3.9	high_impact	4.31	0.48	damaging	0.04	damaging	3.31	22.90	deleterious	0.3	0.55	0.93	disease	0.95	disease	0.76	disease	0.87	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-0.92	medium_impact	2.88	high_impact	0.50	0.9	2.34	6.69	0.55	P	0.90	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8734	8734	C	G	MI.441	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	208	70	L	V	Ctt/Gtt	-16.07	0	0	probably_damaging	0.99	neutral	0.33	neutral	3.79	neutral	-0.63	neutral	-2.19	low_impact	1.41	0.8	neutral	0.57	neutral	2.23	17.73	deleterious	0.48	0.65	0.32	neutral	0.48	neutral	0.34	neutral	0.46	neutral	1	0.99	deleterious	0.17	neutral	-2	neutral	0.71	deleterious	-2.65	low_impact	0.12	medium_impact	0.11	medium_impact	0.81	0.9	49.12	8.68	0.32	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7087	7087	A	G	MI.4410	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1184	395	H	R	cAc/cGc	7.3	1	0	probably_damaging	1	deleterious	0.02	neutral	2.76	neutral	-1.49	deleterious	-3.01	high_impact	4.31	0.56	damaging	0.04	damaging	3.10	22.50	deleterious	0.58	0.65	0.9	disease	0.92	disease	0.69	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-0.75	medium_impact	2.88	high_impact	0.55	0.9	2.34	6.69	0.48	P	0.85	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7088	7088	C	G	MI.4411	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1185	395	H	Q	caC/caG	8.69	1	0	probably_damaging	1	neutral	0.07	neutral	2.76	neutral	-1.57	deleterious	-2.66	low_impact	1.46	0.47	damaging	0.06	damaging	2.29	18.08	deleterious	0.61	0.65	0.88	disease	0.54	disease	0.48	neutral	0.64	disease	3	1	deleterious	0.04	neutral	-2	neutral	0.81	deleterious	-3.58	low_impact	-0.43	medium_impact	0.25	medium_impact	0.59	0.9	2.34	6.69	0.52	P	0.83	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7088	7088	C	A	MI.4412	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1185	395	H	Q	caC/caA	8.69	1	0	probably_damaging	1	neutral	0.07	neutral	2.76	neutral	-1.57	deleterious	-2.66	low_impact	1.46	0.47	damaging	0.06	damaging	2.55	19.78	deleterious	0.61	0.65	0.88	disease	0.54	disease	0.48	neutral	0.64	disease	3	1	deleterious	0.04	neutral	-2	neutral	0.81	deleterious	-3.58	low_impact	-0.43	medium_impact	0.25	medium_impact	0.59	0.9	2.34	6.69	0.52	P	0.83	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7089	7089	T	G	MI.4413	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1186	396	W	G	Tga/Gga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-5.18	deleterious	-6.71	high_impact	5.05	0.6	neutral	0.04	damaging	3.98	23.60	deleterious	0.18	0.55	0.93	disease	0.88	disease	0.78	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.19	0.9	2.34	6.59	0.6	P	0.89	disease_causing	0.99	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7089	7089	T	C	MI.4414	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1186	396	W	R	Tga/Cga	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-5.08	deleterious	-7.21	high_impact	4.36	0.57	damaging	0.03	damaging	3.69	23.30	deleterious	0.21	0.55	0.92	disease	0.95	disease	0.81	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.93	high_impact	0.19	0.9	2.34	6.59	0.41	N	0.98	disease_causing	0.98	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7090	7090	G	T	MI.4415	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1187	396	W	L	tGa/tTa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-1.56	deleterious	-6.68	high_impact	4.36	0.64	neutral	0.03	damaging	4.37	24.10	deleterious	0.15	0.55	0.72	disease	0.9	disease	0.75	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.93	high_impact	0.18	0.9	2.34	6.59	0.53	P	0.95	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7090	7090	G	C	MI.4416	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1187	396	W	S	tGa/tCa	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.59	deleterious	-4.09	deleterious	-7.21	high_impact	4.7	0.59	damaging	0.03	damaging	4.17	23.80	deleterious	0.19	0.55	0.89	disease	0.91	disease	0.76	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.16	0.9	2.34	6.59	0.57	P	0.89	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7091	7091	A	T	MI.4417	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1188	396	W	C	tgA/tgT	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-5.43	deleterious	-6.7	high_impact	4.5	0.53	damaging	0.03	damaging	4.22	23.90	deleterious	0.22	0.55	0.95	disease	0.93	disease	0.79	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.20	0.9	2.34	6.59	0.5	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7091	7091	A	C	MI.4418	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1188	396	W	C	tgA/tgC	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-5.43	deleterious	-6.7	high_impact	4.5	0.53	damaging	0.03	damaging	4.14	23.80	deleterious	0.22	0.55	0.95	disease	0.93	disease	0.79	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.06	high_impact	0.20	0.9	2.34	6.59	0.5	P	0.88	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7092	7092	T	C	MI.4419	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1189	397	F	L	Ttt/Ctt	5.91	1	0	probably_damaging	1	neutral	0.07	neutral	2.81	neutral	0.02	deleterious	-2.55	medium_impact	2.23	0.54	damaging	0.05	damaging	4.25	23.90	deleterious	0.25	0.55	0.28	neutral	0.85	disease	0.44	neutral	0.66	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-3.58	low_impact	-0.43	medium_impact	0.96	medium_impact	0.75	0.9	3.12	6.64	0.48	P	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8734	8734	C	A	MI.442	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	208	70	L	I	Ctt/Att	-16.07	0	0	probably_damaging	0.99	neutral	0.42	neutral	3.76	neutral	-1.13	neutral	-1.47	low_impact	1.36	0.84	neutral	0.62	neutral	3.99	23.60	deleterious	0.41	0.65	0.47	neutral	0.52	disease	0.31	neutral	0.47	neutral	1	0.99	deleterious	0.22	neutral	-2	neutral	0.74	deleterious	-2.65	low_impact	0.21	medium_impact	0.07	medium_impact	0.75	0.9	49.12	8.68	0.28	N	0.87	polymorphism	1	0.02	rs878902140	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7092	7092	T	G	MI.4420	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1189	397	F	V	Ttt/Gtt	5.91	1	0	probably_damaging	1	deleterious	0.01	neutral	2.79	neutral	-0.16	deleterious	-2.85	medium_impact	2.79	0.52	damaging	0.06	damaging	4.23	23.90	deleterious	0.28	0.55	0.2	neutral	0.89	disease	0.49	neutral	0.53	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-0.92	medium_impact	1.48	medium_impact	0.49	0.9	3.12	6.64	0.39	N	0.84	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7092	7092	T	A	MI.4421	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1189	397	F	I	Ttt/Att	5.91	1	0	probably_damaging	1	deleterious	0.01	neutral	2.75	neutral	-0.43	deleterious	-2.53	medium_impact	2.9	0.57	damaging	0.07	damaging	4.58	24.40	deleterious	0.21	0.55	0.33	neutral	0.83	disease	0.25	neutral	0.48	neutral	0	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	1.58	medium_impact	0.54	0.9	3.12	6.64	0.47	N	0.88	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7093	7093	T	C	MI.4422	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1190	397	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	deleterious	0.02	neutral	2.65	neutral	-1.94	deleterious	-3.38	medium_impact	2.3	0.55	damaging	0.08	damaging	4.47	24.20	deleterious	0.31	0.55	0.37	neutral	0.84	disease	0.38	neutral	0.54	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-0.75	medium_impact	1.03	medium_impact	0.50	0.9	3.12	6.64	0.41	N	0.84	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7093	7093	T	G	MI.4423	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1190	397	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.78	deleterious	-3.41	high_impact	3.82	0.53	damaging	0.05	damaging	4.33	24.00	deleterious	0.23	0.55	0.66	disease	0.92	disease	0.47	neutral	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.43	high_impact	0.30	0.9	3.12	6.64	0.42	N	0.91	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7093	7093	T	A	MI.4424	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1190	397	F	Y	tTt/tAt	7.53	1	0	probably_damaging	1	neutral	0.23	neutral	2.64	neutral	-2.1	neutral	-0.27	neutral_impact	0.48	0.52	damaging	0.1	damaging	2.85	21.60	deleterious	0.3	0.55	0.26	neutral	0.42	neutral	0.2	neutral	0.44	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.1	medium_impact	-0.66	medium_impact	0.59	0.9	3.12	6.64	0.59	P	0.59	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7094	7094	T	A	MI.4425	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1191	397	F	L	ttT/ttA	7.53	1	0.01	probably_damaging	1	neutral	0.07	neutral	2.81	neutral	0.02	deleterious	-2.55	medium_impact	2.23	0.54	damaging	0.05	damaging	4.57	24.40	deleterious	0.25	0.55	0.28	neutral	0.85	disease	0.44	neutral	0.66	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-3.58	low_impact	-0.43	medium_impact	0.96	medium_impact	0.75	0.9	3.12	6.64	0.5	P	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7094	7094	T	G	MI.4426	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1191	397	F	L	ttT/ttG	7.53	1	0.01	probably_damaging	1	neutral	0.07	neutral	2.81	neutral	0.02	deleterious	-2.55	medium_impact	2.23	0.54	damaging	0.05	damaging	4.45	24.20	deleterious	0.25	0.55	0.28	neutral	0.85	disease	0.44	neutral	0.66	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-3.58	low_impact	-0.43	medium_impact	0.96	medium_impact	0.75	0.9	3.12	6.64	0.49	P	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7095	7095	C	T	MI.4427	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1192	398	P	S	Ccc/Tcc	-1.03	0.01	0	probably_damaging	1	neutral	0.11	neutral	2.18	deleterious	-3.54	deleterious	-4.01	medium_impact	3.44	0.64	neutral	0.05	damaging	3.97	23.60	deleterious	0.39	0.55	0.34	neutral	0.79	disease	0.3	neutral	0.51	disease	0	1	deleterious	0.06	neutral	1	deleterious	0.76	deleterious	-3.58	low_impact	-0.31	medium_impact	2.08	high_impact	0.34	0.9	2.92	6.75	0.31	N	0.85	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7095	7095	C	A	MI.4428	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1192	398	P	T	Ccc/Acc	-1.03	0.01	0	probably_damaging	1	deleterious	0	neutral	2.15	deleterious	-4.39	deleterious	-4.04	high_impact	3.81	0.64	neutral	0.05	damaging	3.80	23.40	deleterious	0.28	0.55	0.56	disease	0.84	disease	0.56	disease	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.42	high_impact	0.80	0.9	2.92	6.75	0.29	N	0.80	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7095	7095	C	G	MI.4429	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1192	398	P	A	Ccc/Gcc	-1.03	0.01	0	probably_damaging	1	deleterious	0	neutral	2.16	deleterious	-4.04	deleterious	-4.04	high_impact	3.92	0.66	neutral	0.06	damaging	3.22	22.70	deleterious	0.25	0.55	0.51	disease	0.77	disease	0.59	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.52	high_impact	0.76	0.9	2.92	6.75	0.3	N	0.76	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8734	8734	C	T	MI.443	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	208	70	L	F	Ctt/Ttt	-16.07	0	0	probably_damaging	1	neutral	0.48	neutral	3.75	neutral	-1.69	deleterious	-2.83	low_impact	1.76	0.79	neutral	0.46	neutral	2.79	21.30	deleterious	0.42	0.65	0.65	disease	0.48	neutral	0.36	neutral	0.58	disease	2	0.99	deleterious	0.24	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	0.27	medium_impact	0.41	medium_impact	0.73	0.9	49.12	8.68	0.25	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7096	7096	C	G	MI.4430	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1193	398	P	R	cCc/cGc	4.52	0.99	0	probably_damaging	1	deleterious	0	neutral	2.3	neutral	-2.1	deleterious	-4.57	high_impact	4.07	0.63	neutral	0.03	damaging	3.76	23.30	deleterious	0.21	0.55	0.57	disease	0.94	disease	0.72	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.66	high_impact	0.73	0.9	2.92	6.75	0.41	N	0.90	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7096	7096	C	T	MI.4431	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1193	398	P	L	cCc/cTc	4.52	0.99	0	probably_damaging	1	deleterious	0	neutral	2.13	deleterious	-5.11	deleterious	-5.1	high_impact	4.41	0.67	neutral	0.02	damaging	4.53	24.30	deleterious	0.28	0.55	0.67	disease	0.91	disease	0.56	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.97	high_impact	0.82	0.9	2.92	6.75	0.44	N	0.87	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7096	7096	C	A	MI.4432	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1193	398	P	H	cCc/cAc	4.52	0.99	0	probably_damaging	1	deleterious	0.01	neutral	2.13	deleterious	-5.35	deleterious	-4.57	high_impact	4.62	0.66	neutral	0.02	damaging	4.11	23.70	deleterious	0.25	0.55	0.32	neutral	0.9	disease	0.6	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-0.92	medium_impact	3.17	high_impact	0.70	0.9	2.92	6.75	0.41	N	0.81	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7098	7098	C	G	MI.4433	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1195	399	L	V	Cta/Gta	-14.22	0	0	probably_damaging	0.98	neutral	0.05	neutral	2.76	neutral	-1.1	neutral	-1.31	medium_impact	2.22	0.5	damaging	0.04	damaging	3.50	23.10	deleterious	0.43	0.55	0.33	neutral	0.66	disease	0.19	neutral	0.43	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.71	deleterious	-2.35	low_impact	-0.52	medium_impact	0.95	medium_impact	0.57	0.9	2.34	6.71	0.39	N	0.66	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7098	7098	C	A	MI.4434	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1195	399	L	M	Cta/Ata	-14.22	0	0	probably_damaging	1	neutral	0.08	neutral	2.71	neutral	-1.42	neutral	-0.85	medium_impact	2.35	0.54	damaging	0.06	damaging	3.82	23.40	deleterious	0.27	0.55	0.5	disease	0.53	disease	0.18	neutral	0.43	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.71	deleterious	-3.58	low_impact	-0.4	medium_impact	1.07	medium_impact	0.74	0.9	2.34	6.71	0.38	N	0.59	polymorphism	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7099	7099	T	G	MI.4435	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1196	399	L	R	cTa/cGa	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.84	neutral	-0.66	deleterious	-2.96	high_impact	4.65	0.52	damaging	0.03	damaging	4.33	24.00	deleterious	0.24	0.55	0.48	neutral	0.93	disease	0.58	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.71	0.9	2.34	6.71	0.43	N	0.90	polymorphism	0.82	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7099	7099	T	A	MI.4436	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1196	399	L	Q	cTa/cAa	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-0.16	deleterious	-2.92	high_impact	4.3	0.54	damaging	0.03	damaging	4.20	23.90	deleterious	0.22	0.55	0.44	neutral	0.82	disease	0.43	neutral	0.65	disease	3	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.87	high_impact	0.62	0.9	2.34	6.71	0.34	N	0.82	polymorphism	0.85	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7099	7099	T	C	MI.4437	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1196	399	L	P	cTa/cCa	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.2	deleterious	-3.43	high_impact	3.96	0.42	damaging	0.03	damaging	4.04	23.70	deleterious	0.18	0.55	0.64	disease	0.89	disease	0.69	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.43	0.9	2.34	6.71	0.39	N	0.83	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7101	7101	T	C	MI.4438	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1198	400	F	L	Ttc/Ctc	-0.57	0.17	0	probably_damaging	1	neutral	0.22	neutral	3.02	neutral	1.61	neutral	-1.95	low_impact	1.68	0.67	neutral	0.45	neutral	1.00	10.66	neutral	0.31	0.55	0.16	neutral	0.76	disease	0.23	neutral	0.48	neutral	0	1	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.11	medium_impact	0.45	medium_impact	0.73	0.9	6.82	9.8	0.39	N	0.83	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7101	7101	T	A	MI.4439	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1198	400	F	I	Ttc/Atc	-0.57	0.17	0	probably_damaging	1	neutral	0.4	neutral	2.88	neutral	0.93	neutral	-1.98	low_impact	0.95	0.67	neutral	0.28	damaging	1.62	13.96	neutral	0.23	0.55	0.2	neutral	0.5	disease	0.17	neutral	0.41	neutral	2	1	deleterious	0.2	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	0.1	medium_impact	-0.22	medium_impact	0.45	0.9	6.82	9.8	0.41	N	0.88	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8735	8735	T	G	MI.444	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	209	70	L	R	cTt/cGt	-1.26	0	0	probably_damaging	1	neutral	0.17	neutral	3.72	neutral	-1.64	deleterious	-4.71	medium_impact	3.32	0.77	neutral	0.41	neutral	4.00	23.60	deleterious	0.15	0.65	0.71	disease	0.84	disease	0.54	disease	0.59	disease	2	1	deleterious	0.09	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.1	medium_impact	1.75	medium_impact	0.78	0.9	49.12	8.68	0.31	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7101	7101	T	G	MI.4440	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1198	400	F	V	Ttc/Gtc	-0.57	0.17	0	probably_damaging	1	deleterious	0.04	neutral	2.92	neutral	0.92	neutral	-2.46	medium_impact	2.92	0.63	neutral	0.15	damaging	3.82	23.40	deleterious	0.34	0.55	0.19	neutral	0.86	disease	0.28	neutral	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-0.58	medium_impact	1.6	medium_impact	0.49	0.9	6.82	9.8	0.33	N	0.84	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7102	7102	T	A	MI.4441	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1199	400	F	Y	tTc/tAc	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.75	neutral	-1.39	neutral	-1.29	high_impact	3.56	0.67	neutral	0.15	damaging	4.26	23.90	deleterious	0.35	0.55	0.51	disease	0.81	disease	0.44	neutral	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	2.19	high_impact	0.59	0.9	6.82	9.8	0.48	P	0.59	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7102	7102	T	G	MI.4442	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1199	400	F	C	tTc/tGc	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.45	deleterious	-3.22	high_impact	4.45	0.64	neutral	0.14	damaging	4.18	23.80	deleterious	0.25	0.55	0.63	disease	0.91	disease	0.59	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.31	0.9	6.82	9.8	0.46	N	0.91	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7102	7102	T	C	MI.4443	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1199	400	F	S	tTc/tCc	3.83	1	0	probably_damaging	1	deleterious	0	neutral	2.75	neutral	-0.89	deleterious	-3.32	high_impact	4.45	0.69	neutral	0.16	damaging	4.38	24.10	deleterious	0.29	0.55	0.43	neutral	0.83	disease	0.58	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.40	0.9	6.82	9.8	0.47	N	0.84	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7103	7103	C	G	MI.4444	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1200	400	F	L	ttC/ttG	7.53	1	0	probably_damaging	1	neutral	0.22	neutral	3.02	neutral	1.61	neutral	-1.95	low_impact	1.68	0.67	neutral	0.45	neutral	1.36	12.59	neutral	0.31	0.55	0.16	neutral	0.76	disease	0.23	neutral	0.48	neutral	0	1	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.11	medium_impact	0.45	medium_impact	0.73	0.9	6.82	9.8	0.51	P	0.83	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7103	7103	C	A	MI.4445	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1200	400	F	L	ttC/ttA	7.53	1	0	probably_damaging	1	neutral	0.22	neutral	3.02	neutral	1.61	neutral	-1.95	low_impact	1.68	0.67	neutral	0.45	neutral	1.60	13.83	neutral	0.31	0.55	0.16	neutral	0.76	disease	0.23	neutral	0.48	neutral	0	1	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.11	medium_impact	0.45	medium_impact	0.73	0.9	6.82	9.8	0.54	P	0.83	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7104	7104	T	A	MI.4446	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1201	401	S	T	Tca/Aca	-4.5	0	0	benign	0.01	neutral	1	neutral	3.22	neutral	2.01	neutral	1.04	neutral_impact	-1.96	0.73	neutral	0.95	neutral	1.09	11.17	neutral	0.35	0.55	0.24	neutral	0.07	neutral	0.13	neutral	0.25	neutral	5	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	1.86	high_impact	-2.91	low_impact	0.81	0.9	9.16	26.09	0.43	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7104	7104	T	G	MI.4447	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1201	401	S	A	Tca/Gca	-4.5	0	0	benign	0.24	deleterious	0.01	neutral	2.97	neutral	-0.26	neutral	-0.5	medium_impact	2.15	0.64	neutral	0.25	damaging	3.78	23.40	deleterious	0.34	0.55	0.25	neutral	0.56	disease	0.35	neutral	0.49	neutral	0	0.99	deleterious	0.39	neutral	1	deleterious	0.21	neutral	-0.29	medium_impact	-0.92	medium_impact	0.89	medium_impact	0.64	0.9	9.16	26.09	0.4	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7104	7104	T	C	MI.4448	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1201	401	S	P	Tca/Cca	-4.5	0	0	possibly_damaging	0.73	deleterious	0	neutral	2.93	neutral	-2.05	neutral	-1.22	medium_impact	2.36	0.56	damaging	0.12	damaging	4.08	23.70	deleterious	0.19	0.55	0.51	disease	0.91	disease	0.44	neutral	0.78	disease	6	1	deleterious	0.14	neutral	4	deleterious	0.69	deleterious	-1.16	low_impact	-1.48	low_impact	1.08	medium_impact	0.58	0.9	9.16	26.09	0.32	N	0.62	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7105	7105	C	T	MI.4449	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1202	401	S	L	tCa/tTa	-0.33	0	0	probably_damaging	0.93	neutral	0.08	neutral	3.05	neutral	0.23	neutral	-0.72	neutral_impact	0.66	0.67	neutral	0.18	damaging	3.66	23.20	deleterious	0.24	0.55	0.24	neutral	0.78	disease	0.23	neutral	0.5	neutral	0	0.98	deleterious	0.08	neutral	-2	neutral	0.67	deleterious	-1.81	low_impact	-0.4	medium_impact	-0.49	medium_impact	0.84	0.9	9.16	26.09	0.36	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8735	8735	T	A	MI.445	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	209	70	L	H	cTt/cAt	-1.26	0	0	probably_damaging	1	neutral	0.33	neutral	3.72	neutral	-2.8	deleterious	-5.47	medium_impact	3.12	0.76	neutral	0.3	neutral	3.93	23.50	deleterious	0.21	0.65	0.48	neutral	0.78	disease	0.48	neutral	0.62	disease	2	1	deleterious	0.17	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	0.12	medium_impact	1.58	medium_impact	0.69	0.9	49.12	8.68	0.3	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7105	7105	C	G	MI.4450	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1202	401	S	W	tCa/tGa	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	2.96	deleterious	-3.38	neutral	-1.15	medium_impact	2.7	0.64	neutral	0.14	damaging	4.49	24.30	deleterious	0.18	0.55	0.75	disease	0.91	disease	0.47	neutral	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	1.39	medium_impact	0.54	0.9	9.16	26.09	0.29	N	0.78	polymorphism	0.56	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7107	7107	G	C	MI.4451	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1204	402	G	R	Ggc/Cgc	-0.57	0.06	0	probably_damaging	1	deleterious	0	neutral	2.41	deleterious	-3.5	deleterious	-3.92	high_impact	4.67	0.46	damaging	0.03	damaging	4.11	23.70	deleterious	0.18	0.55	0.89	disease	0.92	disease	0.81	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.21	high_impact	0.87	0.9	1.75	6.75	0.61	P	0.95	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7107	7107	G	T	MI.4452	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1204	402	G	C	Ggc/Tgc	-0.57	0.06	0	probably_damaging	1	deleterious	0	neutral	2.34	deleterious	-7.27	deleterious	-4.49	high_impact	5.01	0.41	damaging	0.03	damaging	4.27	24.00	deleterious	0.15	0.55	0.91	disease	0.92	disease	0.62	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.53	high_impact	0.54	0.9	1.75	6.75	0.52	P	0.98	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7107	7107	G	A	MI.4453	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1204	402	G	S	Ggc/Agc	-0.57	0.06	0	probably_damaging	1	deleterious	0.01	neutral	2.42	deleterious	-3.16	deleterious	-2.91	medium_impact	3	0.49	damaging	0.05	damaging	4.30	24.00	deleterious	0.21	0.55	0.62	disease	0.83	disease	0.57	disease	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-3.58	low_impact	-0.92	medium_impact	1.67	medium_impact	0.72	0.9	1.75	6.75	0.28	N	0.73	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7108	7108	G	T	MI.4454	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1205	402	G	V	gGc/gTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.34	deleterious	-6.2	deleterious	-4.49	high_impact	4.33	0.51	damaging	0.04	damaging	3.88	23.50	deleterious	0.15	0.55	0.85	disease	0.9	disease	0.71	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	2.9	high_impact	0.52	0.9	1.75	6.75	0.45	N	0.93	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7108	7108	G	A	MI.4455	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1205	402	G	D	gGc/gAc	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.42	deleterious	-3.2	deleterious	-3.4	high_impact	4.67	0.3	damaging	0.03	damaging	3.96	23.60	deleterious	0.17	0.55	0.8	disease	0.9	disease	0.79	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-0.92	medium_impact	3.21	high_impact	0.47	0.9	1.75	6.75	0.75	P	0.97	disease_causing	1	0.47	.	.	.	.	.	.	COSM1138402	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7108	7108	G	C	MI.4456	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1205	402	G	A	gGc/gCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.38	deleterious	-3.99	deleterious	-3	high_impact	3.87	0.61	neutral	0.06	damaging	3.23	22.80	deleterious	0.22	0.55	0.64	disease	0.74	disease	0.67	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.47	high_impact	0.65	0.9	1.75	6.75	0.46	N	0.64	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7110	7110	T	C	MI.4457	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1207	403	Y	H	Tac/Cac	-15.84	0	0	probably_damaging	1	deleterious	0.02	neutral	2.78	neutral	-0.25	neutral	-1.22	medium_impact	2.29	0.64	neutral	0.1	damaging	3.72	23.30	deleterious	0.57	0.6	0.22	neutral	0.54	disease	0.2	neutral	0.48	neutral	1	1	deleterious	0.01	neutral	5	deleterious	0.71	deleterious	-3.58	low_impact	-0.75	medium_impact	1.02	medium_impact	0.23	0.9	7.21	13.45	0.36	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7110	7110	T	G	MI.4458	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1207	403	Y	D	Tac/Gac	-15.84	0	0	probably_damaging	1	deleterious	0.01	neutral	2.79	neutral	0.05	neutral	-1.92	medium_impact	2.29	0.62	neutral	0.11	damaging	4.10	23.70	deleterious	0.38	0.55	0.24	neutral	0.77	disease	0.4	neutral	0.62	disease	2	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	1.02	medium_impact	0.42	0.9	7.21	13.45	0.3	N	0.85	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7110	7110	T	A	MI.4459	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1207	403	Y	N	Tac/Aac	-15.84	0	0	probably_damaging	1	neutral	0.11	neutral	2.81	neutral	0.19	neutral	-1.54	low_impact	1.59	0.66	neutral	0.12	damaging	4.17	23.80	deleterious	0.41	0.55	0.24	neutral	0.75	disease	0.34	neutral	0.56	disease	1	1	deleterious	0.06	neutral	-2	neutral	0.73	deleterious	-3.58	low_impact	-0.31	medium_impact	0.37	medium_impact	0.31	0.9	7.21	13.45	0.31	N	0.80	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8735	8735	T	C	MI.446	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	209	70	L	P	cTt/cCt	-1.26	0	0	probably_damaging	1	neutral	0.28	neutral	3.97	neutral	1.99	deleterious	-5.61	low_impact	1.1	0.74	neutral	0.44	neutral	3.67	23.20	deleterious	0.2	0.65	0.4	neutral	0.81	disease	0.53	disease	0.54	disease	1	1	deleterious	0.14	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.06	medium_impact	-0.16	medium_impact	0.59	0.9	49.12	8.68	0.3	N	1.00	polymorphism	0.9	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7111	7111	A	C	MI.4460	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1208	403	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	deleterious	0.02	neutral	2.82	neutral	0.51	neutral	-1.11	low_impact	1.48	0.65	neutral	0.14	damaging	3.81	23.40	deleterious	0.29	0.55	0.17	neutral	0.6	disease	0.34	neutral	0.48	neutral	0	1	deleterious	0.01	neutral	2	deleterious	0.71	deleterious	-3.58	low_impact	-0.75	medium_impact	0.27	medium_impact	0.31	0.9	7.21	13.45	0.46	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7111	7111	A	G	MI.4461	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1208	403	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	deleterious	0.03	neutral	2.77	neutral	-2.77	neutral	-0.87	low_impact	1.48	0.64	neutral	0.1	damaging	3.63	23.20	deleterious	0.37	0.55	0.66	disease	0.78	disease	0.22	neutral	0.62	disease	2	1	deleterious	0.02	neutral	2	deleterious	0.78	deleterious	-3.58	low_impact	-0.65	medium_impact	0.27	medium_impact	0.07	0.9	7.21	13.45	0.41	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7111	7111	A	T	MI.4462	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1208	403	Y	F	tAc/tTc	7.53	1	0	probably_damaging	1	neutral	0.37	neutral	2.82	neutral	0.19	neutral	0.16	neutral_impact	-0.33	0.71	neutral	0.85	neutral	2.27	17.99	deleterious	0.45	0.55	0.38	neutral	0.47	neutral	0.15	neutral	0.47	neutral	1	1	deleterious	0.19	neutral	-2	neutral	0.72	deleterious	-3.58	low_impact	0.06	medium_impact	-1.4	low_impact	0.34	0.9	7.21	13.45	0.58	P	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7113	7113	A	T	MI.4463	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1210	404	T	S	Acc/Tcc	-7.74	0	0	probably_damaging	0.99	neutral	0.58	neutral	2.85	neutral	0.07	neutral	-0.52	neutral_impact	0.16	0.68	neutral	0.86	neutral	-0.26	0.83	neutral	0.45	0.55	0.32	neutral	0.21	neutral	0.12	neutral	0.38	neutral	2	0.99	deleterious	0.3	neutral	-2	neutral	0.67	deleterious	-2.64	low_impact	0.27	medium_impact	-0.95	medium_impact	0.53	0.9	9.16	16.82	0.42	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7113	7113	A	C	MI.4464	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1210	404	T	P	Acc/Ccc	-7.74	0	0	probably_damaging	1	deleterious	0.02	neutral	2.8	neutral	-1.18	neutral	-1.81	medium_impact	3.02	0.59	damaging	0.4	neutral	3.38	23.00	deleterious	0.21	0.55	0.57	disease	0.83	disease	0.29	neutral	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.58	low_impact	-0.75	medium_impact	1.69	medium_impact	0.46	0.9	9.16	16.82	0.35	N	0.75	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7113	7113	A	G	MI.4465	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1210	404	T	A	Acc/Gcc	-7.74	0	0	probably_damaging	0.99	neutral	0.06	neutral	2.84	neutral	0.3	neutral	-1.06	medium_impact	2.16	0.68	neutral	0.68	neutral	1.55	13.60	neutral	0.67	0.7	0.3	neutral	0.45	neutral	0.31	neutral	0.46	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.68	deleterious	-2.64	low_impact	-0.47	medium_impact	0.9	medium_impact	0.41	0.9	9.16	16.82	0.5	N	0.67	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7114	7114	C	A	MI.4466	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1211	404	T	N	aCc/aAc	3.14	0.97	0	probably_damaging	1	neutral	0.13	neutral	2.81	neutral	-0.3	neutral	-1.11	low_impact	1.07	0.65	neutral	0.67	neutral	2.14	17.12	deleterious	0.52	0.6	0.18	neutral	0.69	disease	0.18	neutral	0.47	neutral	1	1	deleterious	0.07	neutral	-2	neutral	0.69	deleterious	-3.58	low_impact	-0.27	medium_impact	-0.11	medium_impact	0.69	0.9	9.16	16.82	0.52	P	0.71	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7114	7114	C	T	MI.4467	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1211	404	T	I	aCc/aTc	3.14	0.97	0	probably_damaging	1	deleterious	0.02	neutral	2.8	neutral	-1.46	neutral	-1.6	medium_impact	2.58	0.67	neutral	0.55	neutral	2.50	19.45	deleterious	0.44	0.55	0.33	neutral	0.72	disease	0.34	neutral	0.52	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-3.58	low_impact	-0.75	medium_impact	1.28	medium_impact	0.57	0.9	9.16	16.82	0.43	N	0.57	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7114	7114	C	G	MI.4468	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1211	404	T	S	aCc/aGc	3.14	0.97	0	probably_damaging	0.99	neutral	0.58	neutral	2.85	neutral	0.07	neutral	-0.52	neutral_impact	0.16	0.68	neutral	0.86	neutral	0.09	3.48	deleterious	0.45	0.55	0.32	neutral	0.21	neutral	0.12	neutral	0.38	neutral	2	0.99	deleterious	0.3	neutral	-2	neutral	0.67	deleterious	-2.64	low_impact	0.27	medium_impact	-0.95	medium_impact	0.53	0.9	9.16	16.82	0.42	N	0.42	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7116	7116	C	G	MI.4469	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1213	405	L	V	Cta/Gta	-12.13	0	0	probably_damaging	0.99	deleterious	0	neutral	2.73	neutral	-2.04	neutral	-1.12	medium_impact	3.33	0.61	neutral	0.14	damaging	3.56	23.10	deleterious	0.39	0.55	0.23	neutral	0.67	disease	0.56	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.69	deleterious	-2.64	low_impact	-1.48	low_impact	1.98	medium_impact	0.48	0.9	8.58	10.68	0.34	N	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8737	8737	A	C	MI.447	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	211	71	M	L	Ata/Cta	-4.73	0	0	possibly_damaging	0.81	neutral	1	neutral	4.88	neutral	2.79	neutral	-1.2	neutral_impact	0.17	0.88	neutral	0.45	neutral	0.93	10.24	neutral	0.35	0.65	0.27	neutral	0.36	neutral	0.38	neutral	0.44	neutral	1	0.81	neutral	0.6	deleterious	-3	neutral	0.51	deleterious	-1.35	low_impact	1.98	high_impact	-0.95	medium_impact	0.46	0.9	44.25	8.42	0.27	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7116	7116	C	A	MI.4470	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1213	405	L	M	Cta/Ata	-12.13	0	0	probably_damaging	1	neutral	0.16	neutral	2.66	neutral	-1.85	neutral	-0.13	neutral_impact	0.4	0.63	neutral	0.43	neutral	1.95	15.89	deleterious	0.26	0.55	0.59	disease	0.13	neutral	0.17	neutral	0.33	neutral	3	1	deleterious	0.08	neutral	-2	neutral	0.70	deleterious	-3.58	low_impact	-0.21	medium_impact	-0.73	medium_impact	0.70	0.9	8.58	10.68	0.53	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7117	7117	T	G	MI.4471	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1214	405	L	R	cTa/cGa	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-4.26	neutral	-2.47	high_impact	4.37	0.63	neutral	0.1	damaging	4.30	24.00	deleterious	0.19	0.55	0.77	disease	0.93	disease	0.72	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	2.94	high_impact	0.65	0.9	8.58	10.68	0.4	N	0.90	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7117	7117	T	C	MI.4472	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1214	405	L	P	cTa/cCa	-0.1	0	0	probably_damaging	1	deleterious	0.02	neutral	2.66	deleterious	-4.54	deleterious	-2.98	medium_impact	3.48	0.59	damaging	0.11	damaging	4.03	23.70	deleterious	0.18	0.55	0.83	disease	0.9	disease	0.72	disease	0.8	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.92	deleterious	-3.58	low_impact	-0.75	medium_impact	2.11	high_impact	0.48	0.9	8.58	10.68	0.24	N	0.83	disease_causing	0.8	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7117	7117	T	A	MI.4473	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1214	405	L	Q	cTa/cAa	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-4.59	neutral	-2.3	high_impact	4.37	0.68	neutral	0.12	damaging	4.19	23.80	deleterious	0.2	0.55	0.79	disease	0.81	disease	0.58	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.94	high_impact	0.54	0.9	8.58	10.68	0.38	N	0.82	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7119	7119	G	A	MI.4474	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1216	406	D	N	Gac/Aac	-6.81	0	0	benign	0	neutral	1	neutral	3.18	neutral	1.29	neutral	1.96	neutral_impact	-1.94	0.85	neutral	0.93	neutral	-0.35	0.51	neutral	0.77	0.8	0.18	neutral	0.1	neutral	0.11	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	1.86	high_impact	-2.89	low_impact	0.66	0.9	12.67	21.61	0.36	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7119	7119	G	T	MI.4475	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1216	406	D	Y	Gac/Tac	-6.81	0	0	possibly_damaging	0.78	deleterious	0	neutral	2.91	neutral	-1.52	neutral	-1	medium_impact	1.96	0.66	neutral	0.58	neutral	3.97	23.60	deleterious	0.27	0.55	0.6	disease	0.71	disease	0.51	disease	0.54	disease	1	1	deleterious	0.11	neutral	4	deleterious	0.62	deleterious	-1.27	low_impact	-1.48	low_impact	0.71	medium_impact	0.23	0.9	12.67	21.61	0.34	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7119	7119	G	C	MI.4476	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1216	406	D	H	Gac/Cac	-6.81	0	0	possibly_damaging	0.72	neutral	0.62	neutral	2.91	neutral	-1.54	neutral	0.68	neutral_impact	0.24	0.67	neutral	0.85	neutral	1.89	15.53	deleterious	0.43	0.55	0.31	neutral	0.28	neutral	0.24	neutral	0.4	neutral	2	0.67	neutral	0.45	neutral	-3	neutral	0.45	deleterious	-1.14	low_impact	0.31	medium_impact	-0.88	medium_impact	0.31	0.9	12.67	21.61	0.32	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7120	7120	A	C	MI.4477	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1217	406	D	A	gAc/gCc	-0.1	0	0	benign	0.11	deleterious	0	neutral	2.93	neutral	-0.98	neutral	-1.22	medium_impact	2.77	0.63	neutral	0.67	neutral	2.09	16.82	deleterious	0.38	0.55	0.28	neutral	0.43	neutral	0.47	neutral	0.45	neutral	1	1	deleterious	0.45	neutral	1	deleterious	0.19	neutral	0.1	medium_impact	-1.48	low_impact	1.46	medium_impact	0.35	0.9	12.67	21.61	0.49	N	0.44	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7120	7120	A	G	MI.4478	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1217	406	D	G	gAc/gGc	-0.1	0	0	benign	0.18	deleterious	0.01	neutral	2.95	neutral	-0.64	neutral	-0.55	low_impact	1.8	0.67	neutral	0.52	neutral	2.31	18.26	deleterious	0.34	0.55	0.43	neutral	0.62	disease	0.48	neutral	0.5	neutral	0	0.99	deleterious	0.42	neutral	-2	neutral	0.24	neutral	-0.14	medium_impact	-0.92	medium_impact	0.56	medium_impact	0.29	0.9	12.67	21.61	0.41	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7120	7120	A	T	MI.4479	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1217	406	D	V	gAc/gTc	-0.1	0	0	possibly_damaging	0.46	deleterious	0	neutral	2.89	neutral	-2.81	neutral	-1.8	medium_impact	2.77	0.65	neutral	0.64	neutral	3.63	23.20	deleterious	0.28	0.55	0.46	neutral	0.67	disease	0.45	neutral	0.5	neutral	0	1	deleterious	0.27	neutral	4	deleterious	0.46	deleterious	-0.69	medium_impact	-1.48	low_impact	1.46	medium_impact	0.16	0.9	12.67	21.61	0.41	N	0.77	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8737	8737	A	T	MI.448	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	211	71	M	L	Ata/Tta	-4.73	0	0	possibly_damaging	0.81	neutral	1	neutral	4.88	neutral	2.79	neutral	-1.2	neutral_impact	0.17	0.88	neutral	0.45	neutral	1.03	10.84	neutral	0.35	0.65	0.27	neutral	0.36	neutral	0.38	neutral	0.44	neutral	1	0.81	neutral	0.6	deleterious	-3	neutral	0.51	deleterious	-1.35	low_impact	1.98	high_impact	-0.95	medium_impact	0.46	0.9	44.25	8.42	0.27	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7121	7121	C	G	MI.4480	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1218	406	D	E	gaC/gaG	5.91	0.67	0	benign	0.18	deleterious	0	neutral	2.93	neutral	-1.07	neutral	-0.28	medium_impact	2.42	0.63	neutral	0.57	neutral	2.29	18.11	deleterious	0.58	0.65	0.22	neutral	0.52	disease	0.39	neutral	0.5	disease	0	1	deleterious	0.41	neutral	1	deleterious	0.19	neutral	-0.14	medium_impact	-1.48	low_impact	1.14	medium_impact	0.62	0.9	12.67	21.61	0.49	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7121	7121	C	A	MI.4481	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1218	406	D	E	gaC/gaA	5.91	0.67	0	benign	0.18	deleterious	0	neutral	2.93	neutral	-1.07	neutral	-0.28	medium_impact	2.42	0.63	neutral	0.57	neutral	2.59	20.20	deleterious	0.58	0.65	0.22	neutral	0.52	disease	0.39	neutral	0.5	disease	0	1	deleterious	0.41	neutral	1	deleterious	0.19	neutral	-0.14	medium_impact	-1.48	low_impact	1.14	medium_impact	0.62	0.9	12.67	21.61	0.49	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7122	7122	C	G	MI.4482	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1219	407	Q	E	Caa/Gaa	-1.95	0	0	benign	0	neutral	0.82	neutral	2.99	neutral	1.24	neutral	0.09	neutral_impact	-1.22	0.74	neutral	0.85	neutral	-0.42	0.35	neutral	0.61	0.65	0.32	neutral	0.22	neutral	0.13	neutral	0.4	neutral	2	0.17	neutral	0.91	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.56	medium_impact	-2.23	low_impact	0.59	0.9	14.42	24.47	0.4	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7122	7122	C	A	MI.4483	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1219	407	Q	K	Caa/Aaa	-1.95	0	0	benign	0.09	neutral	1	neutral	2.8	neutral	-0.13	neutral	-0.13	neutral_impact	-0.34	0.71	neutral	0.38	neutral	1.08	11.10	neutral	0.57	0.6	0.18	neutral	0.49	neutral	0.17	neutral	0.41	neutral	2	0.09	neutral	0.96	deleterious	-6	neutral	0.17	neutral	0.19	medium_impact	1.86	high_impact	-1.41	low_impact	0.43	0.9	14.42	24.47	0.3	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7123	7123	A	C	MI.4484	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1220	407	Q	P	cAa/cCa	-3.57	0	0	benign	0.24	neutral	0.9	neutral	2.76	neutral	-0.58	neutral	0.31	neutral_impact	-1.3	0.72	neutral	0.95	neutral	-0.92	0.02	neutral	0.25	0.55	0.16	neutral	0.52	disease	0.31	neutral	0.4	neutral	2	0.13	neutral	0.83	deleterious	-6	neutral	0.28	neutral	-0.29	medium_impact	0.72	medium_impact	-2.3	low_impact	0.35	0.9	14.42	24.47	0.26	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7123	7123	A	T	MI.4485	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1220	407	Q	L	cAa/cTa	-3.57	0	0	benign	0.09	neutral	0.1	neutral	2.7	neutral	-2.04	neutral	-1.35	low_impact	1.26	0.72	neutral	0.41	neutral	2.16	17.27	deleterious	0.39	0.55	0.38	neutral	0.64	disease	0.28	neutral	0.46	neutral	1	0.89	neutral	0.51	deleterious	-6	neutral	0.20	neutral	0.19	medium_impact	-0.34	medium_impact	0.06	medium_impact	0.15	0.9	14.42	24.47	0.45	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7123	7123	A	G	MI.4486	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1220	407	Q	R	cAa/cGa	-3.57	0	0	benign	0.09	neutral	0.42	neutral	2.75	neutral	-0.69	neutral	-0.51	neutral_impact	0.76	0.65	neutral	0.2	damaging	1.71	14.48	neutral	0.53	0.6	0.2	neutral	0.64	disease	0.22	neutral	0.49	neutral	0	0.52	neutral	0.67	deleterious	-6	neutral	0.19	neutral	0.19	medium_impact	0.12	medium_impact	-0.4	medium_impact	0.35	0.9	14.42	24.47	0.34	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7124	7124	A	C	MI.4487	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1221	407	Q	H	caA/caC	-0.8	0	0	benign	0	neutral	0.2	neutral	2.68	neutral	-2.49	neutral	-0.54	low_impact	1.26	0.71	neutral	0.48	neutral	2.11	16.92	deleterious	0.55	0.6	0.41	neutral	0.42	neutral	0.2	neutral	0.49	neutral	0	0.8	neutral	0.6	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	-0.14	medium_impact	0.06	medium_impact	0.56	0.9	14.42	24.47	0.51	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7124	7124	A	T	MI.4488	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1221	407	Q	H	caA/caT	-0.8	0	0	benign	0	neutral	0.2	neutral	2.68	neutral	-2.49	neutral	-0.54	low_impact	1.26	0.71	neutral	0.48	neutral	2.33	18.39	deleterious	0.55	0.6	0.41	neutral	0.42	neutral	0.2	neutral	0.49	neutral	0	0.8	neutral	0.6	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	-0.14	medium_impact	0.06	medium_impact	0.56	0.9	14.42	24.47	0.51	N	0.26	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7125	7125	A	G	MI.4489	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1222	408	T	A	Acc/Gcc	-5.89	0	0	benign	0	neutral	0.2	neutral	2.96	neutral	-0.61	neutral	-0.42	low_impact	1.75	0.7	neutral	0.9	neutral	-0.65	0.10	neutral	0.53	0.6	0.3	neutral	0.36	neutral	0.22	neutral	0.45	neutral	1	0.8	neutral	0.6	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	-0.14	medium_impact	0.52	medium_impact	0.32	0.9	11.7	29.21	0.53	P	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8737	8737	A	G	MI.449	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	211	71	M	V	Ata/Gta	-4.73	0	0	possibly_damaging	0.87	neutral	0.18	neutral	4.44	neutral	0.54	neutral	-2.11	low_impact	1.72	0.84	neutral	0.18	damaging	2.52	19.59	deleterious	0.42	0.65	0.37	neutral	0.67	disease	0.49	neutral	0.48	neutral	0	0.93	neutral	0.16	neutral	-3	neutral	0.62	deleterious	-1.54	low_impact	-0.08	medium_impact	0.38	medium_impact	0.58	0.9	44.25	8.42	0.28	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7125	7125	A	T	MI.4490	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1222	408	T	S	Acc/Tcc	-5.89	0	0	benign	0.03	neutral	0.41	neutral	2.97	neutral	-0.47	neutral	-0.1	neutral_impact	0.62	0.67	neutral	0.71	neutral	-0.69	0.08	neutral	0.54	0.6	0.3	neutral	0.39	neutral	0.22	neutral	0.45	neutral	1	0.56	neutral	0.69	deleterious	-6	neutral	0.16	neutral	0.66	medium_impact	0.11	medium_impact	-0.53	medium_impact	0.67	0.9	11.7	29.21	0.45	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7125	7125	A	C	MI.4491	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1222	408	T	P	Acc/Ccc	-5.89	0	0	benign	0.32	neutral	0.07	neutral	2.92	neutral	-1.83	neutral	-0.8	low_impact	1.84	0.59	damaging	0.37	neutral	0.37	6.36	deleterious	0.19	0.55	0.58	disease	0.83	disease	0.38	neutral	0.72	disease	4	0.92	neutral	0.38	neutral	-6	neutral	0.45	deleterious	-0.45	medium_impact	-0.43	medium_impact	0.6	medium_impact	0.57	0.9	11.7	29.21	0.36	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7126	7126	C	T	MI.4492	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1223	408	T	I	aCc/aTc	1.29	0.01	0	benign	0.01	neutral	0.31	neutral	2.96	neutral	-0.65	neutral	-0.79	low_impact	1.4	0.67	neutral	0.76	neutral	0.44	6.94	deleterious	0.48	0.55	0.55	disease	0.58	disease	0.14	neutral	0.45	neutral	1	0.68	neutral	0.65	deleterious	-6	neutral	0.20	neutral	1.12	medium_impact	0	medium_impact	0.19	medium_impact	0.50	0.9	11.7	29.21	0.54	N	0.55	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7126	7126	C	G	MI.4493	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1223	408	T	S	aCc/aGc	1.29	0.01	0	benign	0.03	neutral	0.41	neutral	2.97	neutral	-0.47	neutral	-0.1	neutral_impact	0.62	0.67	neutral	0.71	neutral	-0.36	0.48	neutral	0.54	0.6	0.3	neutral	0.39	neutral	0.22	neutral	0.45	neutral	1	0.56	neutral	0.69	deleterious	-6	neutral	0.16	neutral	0.66	medium_impact	0.11	medium_impact	-0.53	medium_impact	0.67	0.9	11.7	29.21	0.49	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7126	7126	C	A	MI.4494	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1223	408	T	N	aCc/aAc	1.29	0.01	0	benign	0.32	neutral	0.13	neutral	2.93	neutral	-1.39	neutral	-0.21	neutral_impact	0.18	0.66	neutral	0.67	neutral	0.56	7.89	deleterious	0.62	0.65	0.29	neutral	0.64	disease	0.14	neutral	0.43	neutral	1	0.85	neutral	0.41	neutral	-6	neutral	0.40	neutral	-0.45	medium_impact	-0.27	medium_impact	-0.93	medium_impact	0.70	0.9	11.7	29.21	0.58	N	0.71	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7128	7128	T	G	MI.4495	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1225	409	Y	D	Tac/Gac	-3.57	0	0	possibly_damaging	0.73	deleterious	0	neutral	2.78	neutral	-2.07	neutral	-2.21	low_impact	1.94	0.52	damaging	0.39	neutral	2.45	19.15	deleterious	0.31	0.55	0.51	disease	0.78	disease	0.64	disease	0.78	disease	6	1	deleterious	0.14	neutral	1	deleterious	0.71	deleterious	-1.16	low_impact	-1.48	low_impact	0.69	medium_impact	0.54	0.9	14.62	66.11	0.31	N	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7128	7128	T	A	MI.4496	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1225	409	Y	N	Tac/Aac	-3.57	0	0	possibly_damaging	0.72	deleterious	0.02	neutral	2.78	neutral	-1.18	neutral	-2	low_impact	1.38	0.58	damaging	0.56	neutral	2.45	19.14	deleterious	0.38	0.55	0.39	neutral	0.74	disease	0.52	disease	0.62	disease	2	0.98	deleterious	0.15	neutral	1	deleterious	0.63	deleterious	-1.14	low_impact	-0.75	medium_impact	0.18	medium_impact	0.38	0.9	14.62	66.11	0.34	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7128	7128	T	C	MI.4497	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1225	409	Y	H	Tac/Cac	-3.57	0	0	possibly_damaging	0.79	deleterious	0.01	neutral	2.78	neutral	-1.44	neutral	-1.43	neutral_impact	0.5	0.64	neutral	0.41	neutral	1.72	14.53	neutral	0.49	0.55	0.28	neutral	0.51	disease	0.4	neutral	0.49	neutral	0	0.99	deleterious	0.11	neutral	1	deleterious	0.65	deleterious	-1.3	low_impact	-0.92	medium_impact	-0.64	medium_impact	0.51	0.9	14.62	66.11	0.37	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7129	7129	A	C	MI.4498	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1226	409	Y	S	tAc/tCc	5.91	1	0	benign	0.2	deleterious	0.02	neutral	2.82	neutral	0.5	neutral	-1.51	neutral_impact	0.62	0.61	neutral	0.62	neutral	2.05	16.50	deleterious	0.28	0.55	0.24	neutral	0.58	disease	0.53	disease	0.56	disease	1	0.98	neutral	0.41	neutral	-2	neutral	0.37	neutral	-0.19	medium_impact	-0.75	medium_impact	-0.53	medium_impact	0.50	0.9	14.62	66.11	0.52	P	0.64	disease_causing	0.96	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7129	7129	A	G	MI.4499	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1226	409	Y	C	tAc/tGc	5.91	1	0	benign	0.01	deleterious	0	neutral	2.78	neutral	-1.27	neutral	-1.29	low_impact	1.94	0.63	neutral	0.74	neutral	1.74	14.63	neutral	0.34	0.55	0.42	neutral	0.8	disease	0.55	disease	0.78	disease	6	1	deleterious	0.5	deleterious	-2	neutral	0.21	neutral	1.12	medium_impact	-1.48	low_impact	0.69	medium_impact	0.18	0.9	14.62	66.11	0.53	P	0.05	disease_causing	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8545	8545	G	T	MI.45	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	19	7	A	S	Gct/Tct	-1.03	0	0.01	benign	0.06	neutral	1	neutral	4.78	neutral	0.02	neutral	0.22	neutral_impact	0.11	0.91	neutral	0.9	neutral	0.49	7.33	deleterious	0.45	0.65	0.32	neutral	0.22	neutral	0.28	neutral	0.35	neutral	3	0.06	neutral	0.97	deleterious	-6	neutral	0.18	neutral	0.38	medium_impact	1.98	high_impact	-1	low_impact	0.71	0.9	9.29	10.06	0.29	N	0.53	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8738	8738	T	A	MI.450	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	212	71	M	K	aTa/aAa	0.82	0.22	0	probably_damaging	0.94	deleterious	0.03	neutral	4.31	neutral	-2.26	deleterious	-4.72	medium_impact	2.37	0.79	neutral	0.08	damaging	3.74	23.30	deleterious	0.21	0.65	0.69	disease	0.87	disease	0.72	disease	0.8	disease	6	0.99	deleterious	0.05	neutral	5	deleterious	0.83	deleterious	-1.89	low_impact	-0.56	medium_impact	0.93	medium_impact	0.46	0.9	44.25	8.42	0.22	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7129	7129	A	T	MI.4500	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1226	409	Y	F	tAc/tTc	5.91	1	0	benign	0.13	neutral	0.07	neutral	2.84	neutral	0.95	neutral	-0.13	neutral_impact	-0.11	0.67	neutral	0.8	neutral	0.78	9.33	deleterious	0.42	0.55	0.17	neutral	0.52	disease	0.29	neutral	0.42	neutral	2	0.92	neutral	0.47	deleterious	-6	neutral	0.24	neutral	0.02	medium_impact	-0.43	medium_impact	-1.2	low_impact	0.40	0.9	14.62	66.11	0.56	P	0.15	disease_causing	0.64	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7131	7131	G	C	MI.4501	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1228	410	A	P	Gcc/Ccc	1.75	1	0	probably_damaging	0.98	neutral	0.17	neutral	2.57	deleterious	-3.58	neutral	-1.12	medium_impact	2.53	0.58	damaging	0.35	neutral	2.88	21.80	deleterious	0.12	0.55	0.66	disease	0.89	disease	0.54	disease	0.8	disease	6	0.99	deleterious	0.1	neutral	1	deleterious	0.89	deleterious	-2.35	low_impact	-0.19	medium_impact	1.24	medium_impact	0.86	0.9	9.16	16.63	0.42	N	0.66	polymorphism	0.87	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7131	7131	G	T	MI.4502	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1228	410	A	S	Gcc/Tcc	1.75	1	0	possibly_damaging	0.5	neutral	0.66	neutral	2.66	neutral	-1.4	neutral	-0.31	neutral_impact	0.12	0.69	neutral	0.53	neutral	1.92	15.74	deleterious	0.38	0.55	0.39	neutral	0.47	neutral	0.23	neutral	0.47	neutral	1	0.42	neutral	0.58	deleterious	-3	neutral	0.34	neutral	-0.76	medium_impact	0.35	medium_impact	-0.99	medium_impact	0.86	0.9	9.16	16.63	0.4	N	0.31	polymorphism	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7131	7131	G	A	MI.4503	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1228	410	A	T	Gcc/Acc	1.75	1	0	benign	0.04	neutral	0.8	neutral	2.61	neutral	-1.76	neutral	0.04	low_impact	1.03	0.72	neutral	0.91	neutral	0.76	9.19	deleterious	0.4	0.55	0.35	neutral	0.45	neutral	0.28	neutral	0.47	neutral	1	0.13	neutral	0.88	deleterious	-6	neutral	0.19	neutral	0.54	medium_impact	0.53	medium_impact	-0.15	medium_impact	0.77	0.9	9.16	16.63	0.41	N	0.36	polymorphism	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7132	7132	C	A	MI.4504	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1229	410	A	D	gCc/gAc	0.36	0.99	0	probably_damaging	0.97	neutral	0.07	neutral	2.59	neutral	-2.52	neutral	-1.46	medium_impact	2.88	0.64	neutral	0.36	neutral	4.60	24.40	deleterious	0.14	0.55	0.64	disease	0.86	disease	0.55	disease	0.8	disease	6	0.99	deleterious	0.05	neutral	1	deleterious	0.84	deleterious	-2.18	low_impact	-0.43	medium_impact	1.56	medium_impact	0.64	0.9	9.16	16.63	0.38	N	0.93	disease_causing	0.68	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7132	7132	C	G	MI.4505	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1229	410	A	G	gCc/gGc	0.36	0.99	0	benign	0.27	neutral	0.43	neutral	2.78	neutral	0.7	neutral	-1.32	neutral_impact	0.5	0.7	neutral	0.57	neutral	1.05	10.94	neutral	0.28	0.55	0.19	neutral	0.42	neutral	0.25	neutral	0.44	neutral	1	0.48	neutral	0.58	deleterious	-6	neutral	0.27	neutral	-0.35	medium_impact	0.13	medium_impact	-0.64	medium_impact	0.79	0.9	9.16	16.63	0.42	N	0.53	polymorphism	0.72	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7132	7132	C	T	MI.4506	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1229	410	A	V	gCc/gTc	0.36	0.99	0	benign	0.38	neutral	0.12	neutral	2.66	neutral	-1.91	neutral	0.27	low_impact	1.9	0.69	neutral	0.54	neutral	2.90	21.90	deleterious	0.3	0.55	0.17	neutral	0.72	disease	0.39	neutral	0.5	disease	0	0.86	neutral	0.37	neutral	-6	neutral	0.53	deleterious	-0.56	medium_impact	-0.29	medium_impact	0.66	medium_impact	0.81	0.9	9.16	16.63	0.48	N	0.53	polymorphism	0.67	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7134	7134	A	C	MI.4507	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1231	411	K	Q	Aaa/Caa	-6.35	0	0	probably_damaging	1	neutral	0.09	neutral	2.63	neutral	-2.02	neutral	-1.77	medium_impact	3.15	0.53	damaging	0.43	neutral	3.48	23.10	deleterious	0.39	0.55	0.38	neutral	0.76	disease	0.41	neutral	0.52	disease	0	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.37	medium_impact	1.81	medium_impact	0.76	0.9	2.53	6.64	0.44	N	0.64	polymorphism	0.66	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7134	7134	A	G	MI.4508	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1231	411	K	E	Aaa/Gaa	-6.35	0	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-1.99	neutral	-1.8	high_impact	4.04	0.52	damaging	0.38	neutral	4.11	23.70	deleterious	0.28	0.55	0.38	neutral	0.91	disease	0.64	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.63	high_impact	0.73	0.9	2.53	6.64	0.42	N	0.75	polymorphism	0.53	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7135	7135	A	C	MI.4509	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1232	411	K	T	aAa/aCa	6.84	1	0	probably_damaging	1	deleterious	0.01	neutral	2.61	neutral	-2.43	deleterious	-2.68	high_impact	3.95	0.57	damaging	0.38	neutral	3.69	23.30	deleterious	0.2	0.55	0.45	neutral	0.87	disease	0.61	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-0.92	medium_impact	2.55	high_impact	0.54	0.9	2.53	6.64	0.49	P	0.76	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8738	8738	T	C	MI.451	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	212	71	M	T	aTa/aCa	0.82	0.22	0	probably_damaging	0.94	neutral	0.06	neutral	4.34	neutral	-0.93	deleterious	-4.19	medium_impact	2.12	0.88	neutral	0.17	damaging	2.74	21.10	deleterious	0.34	0.65	0.5	disease	0.64	disease	0.52	disease	0.47	neutral	1	0.99	deleterious	0.06	neutral	1	deleterious	0.74	deleterious	-1.89	low_impact	-0.38	medium_impact	0.72	medium_impact	0.39	0.9	44.25	8.42	0.32	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7135	7135	A	T	MI.4510	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1232	411	K	M	aAa/aTa	6.84	1	0	probably_damaging	1	neutral	0.05	neutral	2.6	deleterious	-3.69	deleterious	-2.7	high_impact	3.95	0.61	neutral	0.46	neutral	4.09	23.70	deleterious	0.21	0.55	0.29	neutral	0.86	disease	0.62	disease	0.68	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.74	deleterious	-3.58	low_impact	-0.52	medium_impact	2.55	high_impact	0.61	0.9	2.53	6.64	0.53	P	0.89	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7136	7136	A	T	MI.4511	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1233	411	K	N	aaA/aaT	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.66	neutral	-2.43	neutral	-2.17	medium_impact	2.85	0.5	damaging	0.31	neutral	3.99	23.60	deleterious	0.44	0.55	0.4	neutral	0.85	disease	0.55	disease	0.53	disease	1	1	deleterious	0	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	1.53	medium_impact	0.75	0.9	2.53	6.64	0.49	P	0.76	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7136	7136	A	C	MI.4512	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1233	411	K	N	aaA/aaC	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.66	neutral	-2.43	neutral	-2.17	medium_impact	2.85	0.5	damaging	0.31	neutral	3.94	23.50	deleterious	0.44	0.55	0.4	neutral	0.85	disease	0.55	disease	0.53	disease	1	1	deleterious	0	neutral	5	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	1.53	medium_impact	0.75	0.9	2.53	6.64	0.49	P	0.76	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7137	7137	A	G	MI.4513	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1234	412	I	V	Atc/Gtc	3.37	0.99	0	benign	0	neutral	0.49	neutral	2.77	neutral	-0.32	neutral	-0.2	low_impact	1.34	0.7	neutral	0.94	neutral	-0.23	0.93	neutral	0.61	0.65	0.28	neutral	0.42	neutral	0.33	neutral	0.45	neutral	1	0.51	neutral	0.75	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	0.18	medium_impact	0.14	medium_impact	0.59	0.9	13.06	40.88	0.56	P	0.04	polymorphism	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7137	7137	A	C	MI.4514	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1234	412	I	L	Atc/Ctc	3.37	0.99	0	benign	0.02	neutral	0.14	neutral	2.89	neutral	0.53	neutral	-0.48	low_impact	1.82	0.69	neutral	0.56	neutral	0.73	9.03	deleterious	0.38	0.55	0.26	neutral	0.69	disease	0.32	neutral	0.5	disease	0	0.85	neutral	0.56	deleterious	-6	neutral	0.16	neutral	0.83	medium_impact	-0.25	medium_impact	0.58	medium_impact	0.78	0.9	13.06	40.88	0.54	P	0.35	polymorphism	0.96	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7137	7137	A	T	MI.4515	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1234	412	I	F	Atc/Ttc	3.37	0.99	0	benign	0.28	deleterious	0.03	neutral	2.69	neutral	-1.31	neutral	-1.36	medium_impact	3.02	0.62	neutral	0.35	neutral	1.89	15.55	deleterious	0.32	0.55	0.54	disease	0.86	disease	0.5	neutral	0.67	disease	3	0.97	neutral	0.38	neutral	1	deleterious	0.42	neutral	-0.37	medium_impact	-0.65	medium_impact	1.69	medium_impact	0.79	0.9	13.06	40.88	0.42	N	0.59	disease_causing	0.78	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7138	7138	T	C	MI.4516	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1235	412	I	T	aTc/aCc	0.36	0.12	0	benign	0.08	neutral	0.08	neutral	2.68	neutral	-1.57	neutral	-1.24	low_impact	1.73	0.71	neutral	0.97	neutral	0.40	6.59	deleterious	0.29	0.55	0.48	neutral	0.69	disease	0.37	neutral	0.51	disease	0	0.91	neutral	0.5	deleterious	-6	neutral	0.24	neutral	0.24	medium_impact	-0.4	medium_impact	0.5	medium_impact	0.83	0.9	13.06	40.88	0.47	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7138	7138	T	G	MI.4517	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1235	412	I	S	aTc/aGc	0.36	0.12	0	possibly_damaging	0.64	neutral	0.27	neutral	2.66	neutral	-1.85	neutral	-1.48	low_impact	1.93	0.69	neutral	0.72	neutral	1.67	14.26	neutral	0.19	0.55	0.51	disease	0.82	disease	0.39	neutral	0.53	disease	1	0.76	neutral	0.32	neutral	-3	neutral	0.43	deleterious	-0.99	medium_impact	-0.05	medium_impact	0.68	medium_impact	0.68	0.9	13.06	40.88	0.38	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7138	7138	T	A	MI.4518	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1235	412	I	N	aTc/aAc	0.36	0.12	0	possibly_damaging	0.83	deleterious	0.01	neutral	2.62	deleterious	-3.57	neutral	-2.2	high_impact	3.5	0.69	neutral	0.45	neutral	4.44	24.20	deleterious	0.17	0.55	0.71	disease	0.89	disease	0.58	disease	0.68	disease	4	0.99	deleterious	0.09	neutral	5	deleterious	0.76	deleterious	-1.4	low_impact	-0.92	medium_impact	2.13	high_impact	0.72	0.9	13.06	40.88	0.36	N	0.61	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7139	7139	C	A	MI.4519	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1236	412	I	M	atC/atA	1.05	0.1	0	possibly_damaging	0.54	neutral	0.07	neutral	2.67	neutral	-1.68	neutral	-0.74	medium_impact	2.03	0.69	neutral	0.59	neutral	1.19	11.70	neutral	0.39	0.55	0.42	neutral	0.63	disease	0.35	neutral	0.48	neutral	0	0.93	neutral	0.27	neutral	0	NA	0.29	neutral	-0.82	medium_impact	-0.43	medium_impact	0.78	medium_impact	0.82	0.9	13.06	40.88	0.51	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8739	8739	A	T	MI.452	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	213	71	M	I	atA/atT	5.68	0.91	0	probably_damaging	0.91	neutral	0.53	neutral	4.5	neutral	1.13	neutral	-1.79	neutral_impact	-0.08	0.8	neutral	0.41	neutral	1.71	14.47	neutral	0.35	0.65	0.3	neutral	0.36	neutral	0.42	neutral	0.44	neutral	1	0.9	neutral	0.31	neutral	-2	neutral	0.63	deleterious	-1.71	low_impact	0.32	medium_impact	-1.17	low_impact	0.59	0.9	44.25	8.42	0.4	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7139	7139	C	G	MI.4520	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1236	412	I	M	atC/atG	1.05	0.1	0	possibly_damaging	0.54	neutral	0.07	neutral	2.67	neutral	-1.68	neutral	-0.74	medium_impact	2.03	0.69	neutral	0.59	neutral	0.75	9.17	deleterious	0.39	0.55	0.42	neutral	0.63	disease	0.35	neutral	0.48	neutral	0	0.93	neutral	0.27	neutral	0	NA	0.29	neutral	-0.82	medium_impact	-0.43	medium_impact	0.78	medium_impact	0.82	0.9	13.06	40.88	0.5	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7140	7140	C	A	MI.4521	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1237	413	H	N	Cat/Aat	-4.04	0	0	benign	0.36	deleterious	0	neutral	2.74	neutral	-2.95	neutral	-1.08	medium_impact	3.24	0.66	neutral	0.39	neutral	2.45	19.13	deleterious	0.44	0.55	0.45	neutral	0.9	disease	0.69	disease	0.77	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.49	deleterious	-0.52	medium_impact	-1.48	low_impact	1.89	medium_impact	0.72	0.9	10.53	13.67	0.36	N	0.56	polymorphism	0.94	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7140	7140	C	G	MI.4522	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1237	413	H	D	Cat/Gat	-4.04	0	0	possibly_damaging	0.82	deleterious	0	neutral	2.73	deleterious	-3.06	neutral	-1.38	high_impact	4.21	0.63	neutral	0.32	neutral	3.91	23.50	deleterious	0.22	0.55	0.47	neutral	0.92	disease	0.78	disease	0.81	disease	6	1	deleterious	0.09	neutral	5	deleterious	0.62	deleterious	-1.38	low_impact	-1.48	low_impact	2.79	high_impact	0.74	0.9	10.53	13.67	0.48	N	0.78	polymorphism	0.83	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7140	7140	C	T	MI.4523	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1237	413	H	Y	Cat/Tat	-4.04	0	0	possibly_damaging	0.63	deleterious	0	neutral	2.72	deleterious	-3.4	neutral	-1.26	high_impact	3.66	0.64	neutral	0.29	neutral	3.60	23.20	deleterious	0.43	0.55	0.62	disease	0.91	disease	0.7	disease	0.78	disease	6	1	deleterious	0.19	neutral	5	deleterious	0.76	deleterious	-0.97	medium_impact	-1.48	low_impact	2.28	high_impact	0.61	0.9	10.53	13.67	0.32	N	0.78	polymorphism	0.93	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7141	7141	A	C	MI.4524	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1238	413	H	P	cAt/cCt	4.52	1	0	possibly_damaging	0.81	deleterious	0.01	neutral	2.72	deleterious	-3.5	neutral	-1.88	high_impact	3.66	0.62	neutral	0.29	neutral	3.21	22.70	deleterious	0.21	0.55	0.62	disease	0.96	disease	0.78	disease	0.9	disease	8	0.99	deleterious	0.1	neutral	5	deleterious	0.77	deleterious	-1.35	low_impact	-0.92	medium_impact	2.28	high_impact	0.60	0.9	10.53	13.67	0.51	P	0.83	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7141	7141	A	T	MI.4525	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1238	413	H	L	cAt/cTt	4.52	1	0	possibly_damaging	0.74	neutral	0.07	neutral	2.77	neutral	-2.14	neutral	-2.37	high_impact	4.21	0.68	neutral	0.38	neutral	4.01	23.60	deleterious	0.23	0.55	0.34	neutral	0.94	disease	0.7	disease	0.84	disease	7	0.95	neutral	0.17	neutral	1	deleterious	0.74	deleterious	-1.18	low_impact	-0.43	medium_impact	2.79	high_impact	0.48	0.9	10.53	13.67	0.6	P	0.73	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7141	7141	A	G	MI.4526	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1238	413	H	R	cAt/cGt	4.52	1	0	possibly_damaging	0.67	deleterious	0	neutral	2.73	deleterious	-3.01	neutral	-0.89	high_impact	3.52	0.63	neutral	0.28	neutral	2.92	21.90	deleterious	0.51	0.6	0.43	neutral	0.94	disease	0.74	disease	0.88	disease	8	1	deleterious	0.17	neutral	5	deleterious	0.77	deleterious	-1.05	low_impact	-1.48	low_impact	2.15	high_impact	0.63	0.9	10.53	13.67	0.49	N	0.68	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7142	7142	T	G	MI.4527	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1239	413	H	Q	caT/caG	8.69	1	0	benign	0.15	neutral	0.49	neutral	2.9	neutral	-0.6	neutral	0.47	neutral_impact	-0.26	0.77	neutral	0.92	neutral	-0.90	0.03	neutral	0.54	0.6	0.33	neutral	0.2	neutral	0.46	neutral	0.34	neutral	3	0.42	neutral	0.67	deleterious	-6	neutral	0.20	neutral	-0.05	medium_impact	0.18	medium_impact	-1.34	low_impact	0.81	0.9	10.53	13.67	0.57	P	0.06	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7142	7142	T	A	MI.4528	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1239	413	H	Q	caT/caA	8.69	1	0	benign	0.15	neutral	0.49	neutral	2.9	neutral	-0.6	neutral	0.47	neutral_impact	-0.26	0.77	neutral	0.92	neutral	-0.81	0.04	neutral	0.54	0.6	0.33	neutral	0.2	neutral	0.46	neutral	0.34	neutral	3	0.42	neutral	0.67	deleterious	-6	neutral	0.20	neutral	-0.05	medium_impact	0.18	medium_impact	-1.34	low_impact	0.81	0.9	10.53	13.67	0.58	P	0.06	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7143	7143	T	G	MI.4529	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1240	414	F	V	Ttc/Gtc	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.34	neutral	-2.59	deleterious	-3.44	high_impact	4.37	0.69	neutral	0.04	damaging	4.30	24.00	deleterious	0.19	0.55	0.65	disease	0.92	disease	0.61	disease	0.72	disease	4	1	deleterious	0	deleterious	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.94	high_impact	0.75	0.9	2.14	6.8	0.37	N	0.84	polymorphism	0.62	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8739	8739	A	C	MI.453	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	213	71	M	I	atA/atC	5.68	0.91	0	probably_damaging	0.91	neutral	0.53	neutral	4.5	neutral	1.13	neutral	-1.79	neutral_impact	-0.08	0.8	neutral	0.41	neutral	1.66	14.21	neutral	0.35	0.65	0.3	neutral	0.36	neutral	0.42	neutral	0.44	neutral	1	0.9	neutral	0.31	neutral	-2	neutral	0.63	deleterious	-1.71	low_impact	0.32	medium_impact	-1.17	low_impact	0.59	0.9	44.25	8.42	0.39	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7143	7143	T	C	MI.4530	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1240	414	F	L	Ttc/Ctc	-3.34	0	0	probably_damaging	0.99	deleterious	0	neutral	2.38	neutral	-2.16	deleterious	-2.95	high_impact	4.02	0.72	neutral	0.04	damaging	4.31	24.00	deleterious	0.38	0.55	0.48	neutral	0.87	disease	0.6	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.61	high_impact	0.80	0.9	2.14	6.8	0.25	N	0.83	polymorphism	0.76	0.27	rs879117005	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7143	7143	T	A	MI.4531	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1240	414	F	I	Ttc/Atc	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	2.37	neutral	-2.25	deleterious	-2.95	high_impact	4.02	0.71	neutral	0.05	damaging	4.71	24.60	deleterious	0.18	0.55	0.68	disease	0.9	disease	0.66	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.61	high_impact	0.73	0.9	2.14	6.8	0.31	N	0.88	polymorphism	0.77	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7144	7144	T	G	MI.4532	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1241	414	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	neutral	0.06	neutral	2.25	deleterious	-4.73	deleterious	-3.94	high_impact	4.16	0.73	neutral	0.04	damaging	4.23	23.90	deleterious	0.15	0.55	0.89	disease	0.91	disease	0.69	disease	0.8	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.87	deleterious	-3.58	low_impact	-0.47	medium_impact	2.74	high_impact	0.52	0.9	2.14	6.8	0.5	N	0.91	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7144	7144	T	A	MI.4533	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1241	414	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.27	deleterious	-4.19	neutral	-1.48	high_impact	4.25	0.71	neutral	0.04	damaging	4.30	24.00	deleterious	0.18	0.55	0.3	neutral	0.87	disease	0.58	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.64	low_impact	-1.48	low_impact	2.83	high_impact	0.75	0.9	2.14	6.8	0.51	N	0.59	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7144	7144	T	C	MI.4534	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1241	414	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.28	deleterious	-3.65	deleterious	-3.93	high_impact	4.08	0.73	neutral	0.05	damaging	4.39	24.10	deleterious	0.11	0.55	0.63	disease	0.9	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.67	high_impact	0.67	0.9	2.14	6.8	0.48	N	0.84	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7145	7145	C	A	MI.4535	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1242	414	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.38	neutral	-2.16	deleterious	-2.95	high_impact	4.02	0.72	neutral	0.04	damaging	4.76	24.70	deleterious	0.38	0.55	0.48	neutral	0.87	disease	0.6	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.61	high_impact	0.80	0.9	2.14	6.8	0.51	N	0.83	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7145	7145	C	G	MI.4536	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1242	414	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	2.38	neutral	-2.16	deleterious	-2.95	high_impact	4.02	0.72	neutral	0.04	damaging	4.48	24.20	deleterious	0.38	0.55	0.48	neutral	0.87	disease	0.6	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.64	low_impact	-1.48	low_impact	2.61	high_impact	0.80	0.9	2.14	6.8	0.51	N	0.83	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7146	7146	A	G	MI.4537	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1243	415	T	A	Act/Gct	-3.8	0	0	benign	0.02	neutral	0.51	neutral	2.86	neutral	-0.07	neutral	-0.18	neutral_impact	0.1	0.9	neutral	1	neutral	-0.04	2.19	deleterious	0.4	0.55	0.17	neutral	0.22	neutral	0.3	neutral	0.4	neutral	2	0.46	neutral	0.75	deleterious	-6	neutral	0.10	neutral	0.83	medium_impact	0.2	medium_impact	-1.01	low_impact	0.68	0.9	14.23	27.59	0.3	N	0.00	polymorphism	1	0.01	rs372136420	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7146	7146	A	C	MI.4538	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1243	415	T	P	Act/Cct	-3.8	0	0	benign	0	neutral	0.2	neutral	2.77	neutral	-2.71	neutral	-1.09	low_impact	0.92	0.67	neutral	0.49	neutral	0.65	8.51	deleterious	0.12	0.55	0.49	neutral	0.73	disease	0.55	disease	0.7	disease	4	0.8	neutral	0.6	deleterious	-6	neutral	0.25	neutral	2.07	high_impact	-0.14	medium_impact	-0.25	medium_impact	0.69	0.9	14.23	27.59	0.35	N	0.20	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7146	7146	A	T	MI.4539	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1243	415	T	S	Act/Tct	-3.8	0	0	benign	0	neutral	0.4	neutral	2.81	neutral	-0.96	neutral	-0.34	neutral_impact	0.26	0.77	neutral	0.97	neutral	-0.04	2.20	deleterious	0.31	0.55	0.22	neutral	0.25	neutral	0.28	neutral	0.44	neutral	1	0.6	neutral	0.7	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.1	medium_impact	-0.86	medium_impact	0.83	0.9	14.23	27.59	0.44	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8740	8740	C	A	MI.454	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	214	72	L	M	Cta/Ata	-1.26	0	0	probably_damaging	1	neutral	0.09	neutral	4.28	deleterious	-3.07	neutral	-1.73	medium_impact	2.38	0.88	neutral	0.17	damaging	3.58	23.20	deleterious	0.33	0.65	0.67	disease	0.49	neutral	0.42	neutral	0.53	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.28	medium_impact	0.94	medium_impact	0.75	0.9	27.88	11.58	0.38	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7147	7147	C	A	MI.4540	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1244	415	T	N	aCt/aAt	-0.33	0	0	benign	0.09	neutral	0.31	neutral	2.77	neutral	-2.12	neutral	-0.81	low_impact	1.54	0.6	neutral	0.58	neutral	0.67	8.64	deleterious	0.33	0.55	0.42	neutral	0.51	disease	0.4	neutral	0.49	neutral	0	0.65	neutral	0.61	deleterious	-6	neutral	0.20	neutral	0.19	medium_impact	0	medium_impact	0.32	medium_impact	0.83	0.9	14.23	27.59	0.47	N	0.20	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7147	7147	C	T	MI.4541	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1244	415	T	I	aCt/aTt	-0.33	0	0	benign	0	neutral	0.41	neutral	2.88	neutral	0.01	neutral	0.46	neutral_impact	-1.27	0.8	neutral	0.96	neutral	0.05	3.06	deleterious	0.22	0.55	0.18	neutral	0.31	neutral	0.19	neutral	0.44	neutral	1	0.59	neutral	0.71	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.11	medium_impact	-2.27	low_impact	0.77	0.9	14.23	27.59	0.43	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7147	7147	C	G	MI.4542	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1244	415	T	S	aCt/aGt	-0.33	0	0	benign	0	neutral	0.4	neutral	2.81	neutral	-0.96	neutral	-0.34	neutral_impact	0.26	0.77	neutral	0.97	neutral	0.16	4.26	deleterious	0.31	0.55	0.22	neutral	0.25	neutral	0.28	neutral	0.44	neutral	1	0.6	neutral	0.7	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.1	medium_impact	-0.86	medium_impact	0.83	0.9	14.23	27.59	0.43	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7149	7149	A	T	MI.4543	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1246	416	I	F	Atc/Ttc	-6.81	0	0	possibly_damaging	0.56	neutral	0.14	neutral	2.78	neutral	-0.33	neutral	-1.34	medium_impact	2.48	0.59	damaging	0.35	neutral	3.66	23.20	deleterious	0.28	0.55	0.3	neutral	0.72	disease	0.6	disease	0.67	disease	3	0.85	neutral	0.29	neutral	0	NA	0.51	deleterious	-0.86	medium_impact	-0.25	medium_impact	1.19	medium_impact	0.75	0.9	11.31	15.83	0.34	N	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7149	7149	A	G	MI.4544	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1246	416	I	V	Atc/Gtc	-6.81	0	0	benign	0	neutral	1	neutral	2.83	neutral	0.25	neutral	-0.06	neutral_impact	0.54	0.69	neutral	0.95	neutral	-1.29	0.01	neutral	0.46	0.55	0.27	neutral	0.15	neutral	0.31	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	1.86	high_impact	-0.6	medium_impact	0.63	0.9	11.31	15.83	0.38	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7149	7149	A	C	MI.4545	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1246	416	I	L	Atc/Ctc	-6.81	0	0	benign	0.08	neutral	0.93	neutral	3.16	neutral	1.97	neutral	-0.48	neutral_impact	0.08	0.71	neutral	0.68	neutral	0.38	6.47	deleterious	0.29	0.55	0.16	neutral	0.32	neutral	0.28	neutral	0.45	neutral	1	0.02	neutral	0.93	deleterious	-6	neutral	0.10	neutral	0.24	medium_impact	0.82	medium_impact	-1.03	low_impact	0.70	0.9	11.31	15.83	0.32	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7150	7150	T	G	MI.4546	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1247	416	I	S	aTc/aGc	0.82	0.67	0	possibly_damaging	0.8	neutral	0.09	neutral	2.75	neutral	-0.81	neutral	-1.42	neutral_impact	0.54	0.72	neutral	0.7	neutral	1.44	13.02	neutral	0.17	0.55	0.48	neutral	0.58	disease	0.42	neutral	0.48	neutral	0	0.94	neutral	0.15	neutral	-3	neutral	0.54	deleterious	-1.32	low_impact	-0.37	medium_impact	-0.6	medium_impact	0.70	0.9	11.31	15.83	0.36	N	0.56	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7150	7150	T	A	MI.4547	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1247	416	I	N	aTc/aAc	0.82	0.67	0	probably_damaging	0.95	deleterious	0	neutral	2.68	deleterious	-3.05	neutral	-2.02	medium_impact	2.89	0.65	neutral	0.4	neutral	4.20	23.90	deleterious	0.16	0.55	0.65	disease	0.78	disease	0.62	disease	0.74	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.75	deleterious	-1.96	low_impact	-1.48	low_impact	1.57	medium_impact	0.74	0.9	11.31	15.83	0.27	N	0.75	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7150	7150	T	C	MI.4548	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1247	416	I	T	aTc/aCc	0.82	0.67	0	possibly_damaging	0.54	neutral	0.23	neutral	2.76	neutral	-0.64	neutral	-0.9	neutral_impact	0.23	0.74	neutral	0.75	neutral	-0.33	0.58	neutral	0.24	0.55	0.29	neutral	0.33	neutral	0.37	neutral	0.44	neutral	1	0.76	neutral	0.35	neutral	-3	neutral	0.30	neutral	-0.82	medium_impact	-0.1	medium_impact	-0.89	medium_impact	0.76	0.9	11.31	15.83	0.4	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7151	7151	C	G	MI.4549	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1248	416	I	M	atC/atG	5.91	0.97	0	possibly_damaging	0.8	neutral	0.16	neutral	2.79	neutral	-0.25	neutral	-0.63	low_impact	0.84	0.69	neutral	0.63	neutral	1.77	14.82	neutral	0.3	0.55	0.48	neutral	0.3	neutral	0.33	neutral	0.41	neutral	2	0.9	neutral	0.18	neutral	-3	neutral	0.44	deleterious	-1.32	low_impact	-0.21	medium_impact	-0.32	medium_impact	0.80	0.9	11.31	15.83	0.58	P	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8740	8740	C	G	MI.455	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	214	72	L	V	Cta/Gta	-1.26	0	0	probably_damaging	0.99	neutral	0.15	neutral	4.34	neutral	-1.48	deleterious	-2.63	low_impact	1.79	0.83	neutral	0.13	damaging	3.29	22.80	deleterious	0.32	0.65	0.38	neutral	0.6	disease	0.61	disease	0.5	disease	0	0.99	deleterious	0.08	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	-0.13	medium_impact	0.44	medium_impact	0.68	0.9	27.88	11.58	0.26	N	0.39	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7151	7151	C	A	MI.4550	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1248	416	I	M	atC/atA	5.91	0.97	0	possibly_damaging	0.8	neutral	0.16	neutral	2.79	neutral	-0.25	neutral	-0.63	low_impact	0.84	0.69	neutral	0.63	neutral	2.30	18.16	deleterious	0.3	0.55	0.48	neutral	0.3	neutral	0.33	neutral	0.41	neutral	2	0.9	neutral	0.18	neutral	-3	neutral	0.44	deleterious	-1.32	low_impact	-0.21	medium_impact	-0.32	medium_impact	0.80	0.9	11.31	15.83	0.59	P	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7152	7152	A	T	MI.4551	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1249	417	M	L	Ata/Tta	-8.89	0	0	benign	0.03	neutral	0.05	neutral	2.89	neutral	0.87	neutral	-1.39	medium_impact	2.25	0.56	damaging	0.45	neutral	1.68	14.28	neutral	0.4	0.55	0.21	neutral	0.84	disease	0.53	disease	0.52	disease	0	0.95	neutral	0.51	deleterious	-3	neutral	0.24	neutral	0.66	medium_impact	-0.52	medium_impact	0.98	medium_impact	0.60	0.9	7.02	13.9	0.37	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7152	7152	A	C	MI.4552	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1249	417	M	L	Ata/Cta	-8.89	0	0	benign	0.03	neutral	0.05	neutral	2.89	neutral	0.87	neutral	-1.39	medium_impact	2.25	0.56	damaging	0.45	neutral	1.61	13.89	neutral	0.4	0.55	0.21	neutral	0.84	disease	0.53	disease	0.52	disease	0	0.95	neutral	0.51	deleterious	-3	neutral	0.24	neutral	0.66	medium_impact	-0.52	medium_impact	0.98	medium_impact	0.60	0.9	7.02	13.9	0.37	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7152	7152	A	G	MI.4553	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1249	417	M	V	Ata/Gta	-8.89	0	0	benign	0.04	deleterious	0	neutral	2.83	neutral	0.51	neutral	-1.84	medium_impact	3.45	0.57	damaging	0.37	neutral	1.10	11.22	neutral	0.42	0.55	0.22	neutral	0.9	disease	0.68	disease	0.75	disease	5	1	deleterious	0.48	deleterious	1	deleterious	0.27	neutral	0.54	medium_impact	-1.48	low_impact	2.09	high_impact	0.59	0.9	7.02	13.9	0.36	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7153	7153	T	C	MI.4554	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1250	417	M	T	aTa/aCa	8.69	1	0	benign	0.01	neutral	0.09	neutral	2.82	neutral	1.33	deleterious	-2.68	low_impact	1.75	0.52	damaging	0.5	neutral	0.11	3.68	deleterious	0.3	0.55	0.25	neutral	0.8	disease	0.55	disease	0.51	disease	0	0.91	neutral	0.54	deleterious	-6	neutral	0.27	neutral	1.12	medium_impact	-0.37	medium_impact	0.52	medium_impact	0.40	0.9	7.02	13.9	0.56	P	0.79	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7153	7153	T	A	MI.4555	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1250	417	M	K	aTa/aAa	8.69	1	0	benign	0.09	deleterious	0	neutral	2.7	neutral	-1.82	deleterious	-2.78	high_impact	4.73	0.58	damaging	0.37	neutral	2.29	18.11	deleterious	0.2	0.55	0.56	disease	0.95	disease	0.8	disease	0.91	disease	8	1	deleterious	0.46	neutral	2	deleterious	0.41	neutral	0.19	medium_impact	-1.48	low_impact	3.27	high_impact	0.62	0.9	7.02	13.9	0.68	P	0.93	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7154	7154	A	T	MI.4556	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1251	417	M	I	atA/atT	4.76	1	0	benign	0.09	deleterious	0	neutral	2.82	neutral	0.22	neutral	-1.86	medium_impact	3.49	0.54	damaging	0.45	neutral	1.74	14.62	neutral	0.43	0.55	0.21	neutral	0.9	disease	0.71	disease	0.74	disease	5	1	deleterious	0.46	neutral	1	deleterious	0.31	neutral	0.19	medium_impact	-1.48	low_impact	2.12	high_impact	0.62	0.9	7.02	13.9	0.53	P	0.87	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7154	7154	A	C	MI.4557	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1251	417	M	I	atA/atC	4.76	1	0	benign	0.09	deleterious	0	neutral	2.82	neutral	0.22	neutral	-1.86	medium_impact	3.49	0.54	damaging	0.45	neutral	1.65	14.12	neutral	0.43	0.55	0.21	neutral	0.9	disease	0.71	disease	0.74	disease	5	1	deleterious	0.46	neutral	1	deleterious	0.31	neutral	0.19	medium_impact	-1.48	low_impact	2.12	high_impact	0.62	0.9	7.02	13.9	0.54	P	0.87	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7155	7155	T	C	MI.4558	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1252	418	F	L	Ttc/Ctc	0.59	0.99	0	probably_damaging	0.98	deleterious	0	neutral	2.74	neutral	-1.41	deleterious	-2.88	medium_impact	3.01	0.74	neutral	0.07	damaging	4.21	23.90	deleterious	0.32	0.55	0.2	neutral	0.83	disease	0.64	disease	0.66	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-2.35	low_impact	-1.48	low_impact	1.68	medium_impact	0.77	0.9	2.14	6.77	0.38	N	0.83	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7155	7155	T	A	MI.4559	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1252	418	F	I	Ttc/Atc	0.59	0.99	0	probably_damaging	0.99	deleterious	0	neutral	2.68	neutral	-2.15	deleterious	-2.88	high_impact	4.31	0.72	neutral	0.08	damaging	4.55	24.30	deleterious	0.19	0.55	0.41	neutral	0.88	disease	0.7	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.64	low_impact	-1.48	low_impact	2.88	high_impact	0.64	0.9	2.14	6.77	0.43	N	0.88	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8741	8741	T	G	MI.456	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	215	72	L	R	cTa/cGa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	4.23	deleterious	-4.81	deleterious	-5.32	high_impact	3.82	0.79	neutral	0.12	damaging	4.08	23.70	deleterious	0.13	0.65	0.79	disease	0.9	disease	0.73	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.18	high_impact	0.66	0.9	27.88	11.58	0.36	N	1.00	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	T8741G	MILS protective factor	-	+	Reported	1	.	P	P	damaging
chrM	7155	7155	T	G	MI.4560	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1252	418	F	V	Ttc/Gtc	0.59	0.99	0	probably_damaging	1	deleterious	0.03	neutral	2.72	neutral	-1.93	deleterious	-3.36	high_impact	3.76	0.7	neutral	0.07	damaging	4.23	23.90	deleterious	0.21	0.55	0.45	neutral	0.9	disease	0.66	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-0.65	medium_impact	2.37	high_impact	0.65	0.9	2.14	6.77	0.37	N	0.84	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7156	7156	T	A	MI.4561	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1253	418	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.62	deleterious	-3.98	neutral	-1.44	high_impact	4.11	0.7	neutral	0.06	damaging	4.53	24.30	deleterious	0.26	0.55	0.72	disease	0.84	disease	0.71	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.35	low_impact	-1.48	low_impact	2.7	high_impact	0.65	0.9	2.14	6.77	0.55	P	0.59	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7156	7156	T	G	MI.4562	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1253	418	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-4.74	deleterious	-3.84	high_impact	5	0.71	neutral	0.06	damaging	4.25	23.90	deleterious	0.19	0.55	0.82	disease	0.89	disease	0.73	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.39	0.9	2.14	6.77	0.72	P	0.91	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7156	7156	T	C	MI.4563	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1253	418	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.69	deleterious	-3.39	deleterious	-3.84	high_impact	4.46	0.73	neutral	0.08	damaging	4.48	24.20	deleterious	0.2	0.55	0.51	disease	0.87	disease	0.7	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-0.92	medium_impact	3.02	high_impact	0.65	0.9	2.14	6.77	0.51	N	0.84	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7157	7157	C	G	MI.4564	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1254	418	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.74	neutral	-1.41	deleterious	-2.88	medium_impact	3.01	0.74	neutral	0.07	damaging	4.50	24.30	deleterious	0.32	0.55	0.2	neutral	0.83	disease	0.64	disease	0.66	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-2.35	low_impact	-1.48	low_impact	1.68	medium_impact	0.77	0.9	2.14	6.77	0.49	N	0.83	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7157	7157	C	A	MI.4565	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1254	418	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.74	neutral	-1.41	deleterious	-2.88	medium_impact	3.01	0.74	neutral	0.07	damaging	4.83	24.80	deleterious	0.32	0.55	0.2	neutral	0.83	disease	0.64	disease	0.66	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.72	deleterious	-2.35	low_impact	-1.48	low_impact	1.68	medium_impact	0.77	0.9	2.14	6.77	0.5	N	0.83	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7158	7158	A	T	MI.4566	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1255	419	I	F	Atc/Ttc	-0.57	0	0	benign	0.14	neutral	0.07	neutral	2.5	neutral	-2.72	neutral	-1.49	medium_impact	2.19	0.72	neutral	0.69	neutral	0.79	9.42	deleterious	0.27	0.55	0.46	neutral	0.73	disease	0.45	neutral	0.53	disease	1	0.92	neutral	0.47	neutral	-3	neutral	0.26	neutral	-0.01	medium_impact	-0.43	medium_impact	0.92	medium_impact	0.81	0.9	14.62	17.04	0.45	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7158	7158	A	G	MI.4567	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1255	419	I	V	Atc/Gtc	-0.57	0	0	benign	0	neutral	0.8	neutral	2.69	neutral	-0.51	neutral	-0.22	neutral_impact	0.74	0.83	neutral	1	neutral	-0.61	0.12	neutral	0.54	0.6	0.26	neutral	0.2	neutral	0.38	neutral	0.35	neutral	3	0.19	neutral	0.9	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.53	medium_impact	-0.42	medium_impact	0.68	0.9	14.62	17.04	0.39	N	0.00	polymorphism	1	0.02	rs878887002	.	.	.	.	.	.	.	89.91	A7158G	Prostate Cancer	+	-	Reported	1	N	P	N,P	neutral
chrM	7158	7158	A	C	MI.4568	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1255	419	I	L	Atc/Ctc	-0.57	0	0	benign	0.01	neutral	0.4	neutral	2.67	neutral	-1.22	neutral	-0.48	low_impact	0.86	0.68	neutral	0.82	neutral	0.28	5.51	deleterious	0.37	0.55	0.31	neutral	0.34	neutral	0.36	neutral	0.44	neutral	1	0.59	neutral	0.7	deleterious	-6	neutral	0.12	neutral	1.12	medium_impact	0.1	medium_impact	-0.31	medium_impact	0.77	0.9	14.62	17.04	0.44	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7159	7159	T	C	MI.4569	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1256	419	I	T	aTc/aCc	0.13	0	0	benign	0	neutral	0.08	neutral	2.48	neutral	-2.91	neutral	-1.62	medium_impact	2.28	0.69	neutral	0.83	neutral	0.32	5.86	deleterious	0.37	0.55	0.23	neutral	0.56	disease	0.48	neutral	0.46	neutral	1	0.92	neutral	0.54	deleterious	-3	neutral	0.14	neutral	2.07	high_impact	-0.4	medium_impact	1.01	medium_impact	0.71	0.9	14.62	17.04	0.49	P	0.51	polymorphism	1	0.05	rs3929989	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8741	8741	T	C	MI.457	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	215	72	L	P	cTa/cCa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	4.22	deleterious	-5.38	deleterious	-6.26	medium_impact	3.48	0.81	neutral	0.12	damaging	3.83	23.40	deleterious	0.15	0.65	0.84	disease	0.88	disease	0.74	disease	0.79	disease	6	1	deleterious	0	neutral	5	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	1.89	medium_impact	0.61	0.9	27.88	11.58	0.27	N	0.89	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7159	7159	T	G	MI.4570	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1256	419	I	S	aTc/aGc	0.13	0	0	benign	0.09	deleterious	0	neutral	2.49	deleterious	-3.42	neutral	-2.22	medium_impact	3.46	0.72	neutral	0.47	neutral	2.52	19.56	deleterious	0.25	0.55	0.41	neutral	0.79	disease	0.65	disease	0.73	disease	5	1	deleterious	0.46	neutral	1	deleterious	0.22	neutral	0.19	medium_impact	-1.48	low_impact	2.1	high_impact	0.66	0.9	14.62	17.04	0.41	N	0.52	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7159	7159	T	A	MI.4571	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1256	419	I	N	aTc/aAc	0.13	0	0	benign	0.14	deleterious	0	neutral	2.44	deleterious	-4.72	deleterious	-2.71	high_impact	4	0.69	neutral	0.38	neutral	2.72	20.90	deleterious	0.26	0.55	0.66	disease	0.82	disease	0.67	disease	0.74	disease	5	1	deleterious	0.43	neutral	2	deleterious	0.31	neutral	-0.01	medium_impact	-1.48	low_impact	2.59	high_impact	0.71	0.9	14.62	17.04	0.39	N	0.65	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7160	7160	C	A	MI.4572	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1257	419	I	M	atC/atA	0.82	0	0	benign	0.02	deleterious	0.02	neutral	2.47	deleterious	-3.34	neutral	-0.87	medium_impact	2.68	0.71	neutral	0.69	neutral	0.93	10.24	neutral	0.36	0.55	0.54	disease	0.44	neutral	0.56	disease	0.62	disease	2	0.98	neutral	0.5	deleterious	1	deleterious	0.15	neutral	0.83	medium_impact	-0.75	medium_impact	1.38	medium_impact	0.85	0.9	14.62	17.04	0.43	N	0.01	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7160	7160	C	G	MI.4573	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1257	419	I	M	atC/atG	0.82	0	0	benign	0.02	deleterious	0.02	neutral	2.47	deleterious	-3.34	neutral	-0.87	medium_impact	2.68	0.71	neutral	0.69	neutral	0.42	6.78	deleterious	0.36	0.55	0.54	disease	0.44	neutral	0.56	disease	0.62	disease	2	0.98	neutral	0.5	deleterious	1	deleterious	0.15	neutral	0.83	medium_impact	-0.75	medium_impact	1.38	medium_impact	0.85	0.9	14.62	17.04	0.43	N	0.01	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7161	7161	G	C	MI.4574	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1258	420	G	R	Ggc/Cgc	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	0.53	deleterious	-9.66	deleterious	-3.65	high_impact	5.05	0.4	damaging	0.01	damaging	4.04	23.70	deleterious	0.1	0.55	0.9	disease	0.89	disease	0.77	disease	0.86	disease	7	1	deleterious	0	deleterious	6	deleterious	0.91	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.73	0.9	NA	NA	0.51	P	0.95	polymorphism	0.65	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7161	7161	G	T	MI.4575	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1258	420	G	C	Ggc/Tgc	-5.42	0	0	probably_damaging	1	deleterious	0	neutral	0.52	deleterious	-10.99	deleterious	-4.1	high_impact	5.05	0.36	damaging	0.01	damaging	4.26	23.90	deleterious	0.15	0.55	0.97	disease	0.87	disease	0.66	disease	0.83	disease	7	1	deleterious	0	deleterious	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.59	0.9	NA	NA	0.45	N	0.98	disease_causing	0.51	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7161	7161	G	A	MI.4576	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1258	420	G	S	Ggc/Agc	-5.42	0	0	probably_damaging	1	deleterious	0.01	neutral	0.58	deleterious	-6.84	deleterious	-2.68	medium_impact	2.98	0.43	damaging	0.03	damaging	4.28	24.00	deleterious	0.22	0.55	0.81	disease	0.75	disease	0.58	disease	0.66	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-3.58	low_impact	-0.92	medium_impact	1.65	medium_impact	0.74	0.9	NA	NA	0.31	N	0.73	polymorphism	0.8	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7162	7162	G	C	MI.4577	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1259	420	G	A	gGc/gCc	6.14	1	0	probably_damaging	1	deleterious	0.03	neutral	0.58	deleterious	-6.67	deleterious	-2.68	high_impact	4.01	0.53	damaging	0.05	damaging	3.30	22.90	deleterious	0.27	0.55	0.81	disease	0.6	disease	0.56	disease	0.6	disease	2	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-0.65	medium_impact	2.6	high_impact	0.75	0.9	NA	NA	0.48	P	0.64	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7162	7162	G	A	MI.4578	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1259	420	G	D	gGc/gAc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	0.53	deleterious	-9.04	deleterious	-3.2	high_impact	5.05	0.28	damaging	0.01	damaging	3.97	23.60	deleterious	0.11	0.55	0.71	disease	0.84	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.51	0.9	NA	NA	0.8	P	0.97	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7162	7162	G	T	MI.4579	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1259	420	G	V	gGc/gTc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	0.53	deleterious	-10.24	deleterious	-4.11	high_impact	4.7	0.44	damaging	0.02	damaging	3.95	23.60	deleterious	0.16	0.55	0.92	disease	0.87	disease	0.68	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.61	0.9	NA	NA	0.56	P	0.93	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8741	8741	T	A	MI.458	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	215	72	L	Q	cTa/cAa	-3.34	0	0	probably_damaging	1	deleterious	0	neutral	4.23	deleterious	-4.98	deleterious	-5.32	medium_impact	2.62	0.82	neutral	0.13	damaging	4.24	23.90	deleterious	0.18	0.65	0.8	disease	0.8	disease	0.62	disease	0.72	disease	4	1	deleterious	0	neutral	5	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	1.15	medium_impact	0.69	0.9	27.88	11.58	0.25	N	0.91	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7164	7164	G	A	MI.4580	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1261	421	V	M	Gta/Ata	-14.45	0	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-0.18	neutral	-1.41	high_impact	4.91	0.63	neutral	0.13	damaging	3.86	23.50	deleterious	0.38	0.55	0.21	neutral	0.67	disease	0.64	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.67	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.97	1	5.07	8.43	0.65	P	0.82	polymorphism	0.94	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7164	7164	G	C	MI.4581	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1261	421	V	L	Gta/Cta	-14.45	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.8	neutral	-0.09	neutral	-1.41	high_impact	4.01	0.57	damaging	0.12	damaging	3.77	23.40	deleterious	0.34	0.55	0.29	neutral	0.69	disease	0.61	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-0.92	medium_impact	2.6	high_impact	0.77	0.9	5.07	8.43	0.31	N	0.55	polymorphism	0.95	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7164	7164	G	T	MI.4582	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1261	421	V	L	Gta/Tta	-14.45	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.8	neutral	-0.09	neutral	-1.41	high_impact	4.01	0.57	damaging	0.12	damaging	3.89	23.50	deleterious	0.34	0.55	0.29	neutral	0.69	disease	0.61	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-0.92	medium_impact	2.6	high_impact	0.77	0.9	5.07	8.43	0.31	N	0.55	polymorphism	0.95	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7165	7165	T	A	MI.4583	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1262	421	V	E	gTa/gAa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-3.54	deleterious	-2.81	high_impact	4.57	0.56	damaging	0.13	damaging	4.83	24.80	deleterious	0.1	0.55	0.66	disease	0.83	disease	0.75	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.58	0.9	5.07	8.43	0.55	P	0.84	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7165	7165	T	C	MI.4584	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1262	421	V	A	gTa/gCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-1.09	neutral	-1.87	high_impact	3.59	0.5	damaging	0.14	damaging	3.74	23.30	deleterious	0.31	0.55	0.33	neutral	0.5	disease	0.58	disease	0.46	neutral	1	1	deleterious	0	neutral	6	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	2.22	high_impact	0.68	0.9	5.07	8.43	0.56	P	0.47	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7165	7165	T	G	MI.4585	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1262	421	V	G	gTa/gGa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.64	neutral	-2.54	deleterious	-3.28	high_impact	4.57	0.57	damaging	0.13	damaging	3.98	23.60	deleterious	0.14	0.55	0.65	disease	0.75	disease	0.64	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.63	0.9	5.07	8.43	0.52	P	0.71	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7167	7167	A	G	MI.4586	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1264	422	N	D	Aat/Gat	-7.97	0	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-3.74	neutral	-2.29	high_impact	4.99	0.53	damaging	0.06	damaging	4.00	23.60	deleterious	0.47	0.55	0.7	disease	0.75	disease	0.72	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.51	high_impact	0.60	0.9	NA	NA	0.65	P	0.92	polymorphism	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7167	7167	A	T	MI.4587	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1264	422	N	Y	Aat/Tat	-7.97	0	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-0.84	deleterious	-3.66	high_impact	3.94	0.6	neutral	0.05	damaging	3.88	23.50	deleterious	0.21	0.55	0.64	disease	0.89	disease	0.69	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.54	high_impact	0.48	0.9	NA	NA	0.27	N	0.93	polymorphism	0.89	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7167	7167	A	C	MI.4588	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1264	422	N	H	Aat/Cat	-7.97	0	0	probably_damaging	1	deleterious	0	neutral	2.63	neutral	-2.38	neutral	-2.29	medium_impact	3.03	0.61	neutral	0.05	damaging	3.23	22.80	deleterious	0.31	0.55	0.54	disease	0.84	disease	0.73	disease	0.78	disease	6	1	deleterious	0	neutral	5	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	1.7	medium_impact	0.55	0.9	NA	NA	0.24	N	0.83	polymorphism	0.97	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7168	7168	A	G	MI.4589	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1265	422	N	S	aAt/aGt	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.66	neutral	-2.1	neutral	-2.29	high_impact	4.09	0.62	neutral	0.06	damaging	3.21	22.70	deleterious	0.5	0.55	0.59	disease	0.76	disease	0.65	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.64	low_impact	-1.48	low_impact	2.68	high_impact	0.38	0.9	NA	NA	0.48	P	0.79	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8743	8743	G	C	MI.459	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	217	73	V	L	Gta/Cta	-4.04	0	0	benign	0.01	neutral	0.6	neutral	4.43	neutral	0.21	neutral	-0.47	neutral_impact	-0.04	0.92	neutral	0.83	neutral	0.22	4.90	deleterious	0.48	0.65	0.25	neutral	0.42	neutral	0.32	neutral	0.44	neutral	1	0.39	neutral	0.8	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.39	medium_impact	-1.13	low_impact	0.72	0.9	25.22	18.16	0.28	N	0.28	polymorphism	1	0.02	rs386829047	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7168	7168	A	T	MI.4590	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1265	422	N	I	aAt/aTt	8.69	1	0	probably_damaging	1	deleterious	0.01	neutral	2.71	neutral	-1.11	deleterious	-4.12	high_impact	4.18	0.63	neutral	0.06	damaging	3.95	23.60	deleterious	0.21	0.55	0.64	disease	0.92	disease	0.68	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-0.92	medium_impact	2.76	high_impact	0.48	0.9	NA	NA	0.5	P	0.98	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7168	7168	A	C	MI.4591	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1265	422	N	T	aAt/aCt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.65	neutral	-1.45	deleterious	-2.75	high_impact	4.18	0.64	neutral	0.06	damaging	3.50	23.10	deleterious	0.36	0.55	0.61	disease	0.81	disease	0.7	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.76	high_impact	0.53	0.9	NA	NA	0.48	P	0.59	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7169	7169	T	G	MI.4592	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1266	422	N	K	aaT/aaG	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.73	deleterious	-2.75	high_impact	4.18	0.59	damaging	0.04	damaging	4.21	23.90	deleterious	0.47	0.55	0.58	disease	0.86	disease	0.74	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.76	high_impact	0.80	0.9	NA	NA	0.54	P	0.92	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7169	7169	T	A	MI.4593	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1266	422	N	K	aaT/aaA	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.61	neutral	-2.73	deleterious	-2.75	high_impact	4.18	0.59	damaging	0.04	damaging	4.53	24.30	deleterious	0.47	0.55	0.58	disease	0.86	disease	0.74	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.76	high_impact	0.80	0.9	NA	NA	0.57	P	0.92	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7170	7170	C	A	MI.4594	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1267	423	L	M	Cta/Ata	-2.42	0	0	benign	0.09	neutral	0.29	neutral	2.43	deleterious	-3.01	neutral	-0.28	neutral_impact	0.78	0.7	neutral	0.97	neutral	0.62	8.28	deleterious	0.36	0.55	0.31	neutral	0.21	neutral	0.33	neutral	0.35	neutral	3	0.67	neutral	0.6	deleterious	-6	neutral	0.14	neutral	0.19	medium_impact	-0.02	medium_impact	-0.38	medium_impact	0.69	0.9	13.65	24.37	0.46	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7170	7170	C	G	MI.4595	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1267	423	L	V	Cta/Gta	-2.42	0	0	benign	0.33	deleterious	0.01	neutral	2.56	neutral	-1.35	neutral	-0.85	medium_impact	2.8	0.6	damaging	0.43	neutral	0.90	10.06	neutral	0.36	0.55	0.22	neutral	0.55	disease	0.37	neutral	0.45	neutral	1	0.99	deleterious	0.34	neutral	1	deleterious	0.26	neutral	-0.47	medium_impact	-0.92	medium_impact	1.49	medium_impact	0.56	0.9	13.65	24.37	0.44	N	0.27	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7171	7171	T	C	MI.4596	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1268	423	L	P	cTa/cCa	-3.34	0	0	probably_damaging	0.92	deleterious	0	neutral	2.39	deleterious	-5.1	deleterious	-2.64	high_impact	4.48	0.53	damaging	0.19	damaging	3.99	23.60	deleterious	0.12	0.55	0.74	disease	0.86	disease	0.72	disease	0.77	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.82	deleterious	-1.76	low_impact	-1.48	low_impact	3.04	high_impact	0.52	0.9	13.65	24.37	0.44	N	0.88	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7171	7171	T	A	MI.4597	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1268	423	L	Q	cTa/cAa	-3.34	0	0	possibly_damaging	0.86	deleterious	0	neutral	2.39	deleterious	-4.7	neutral	-2.15	high_impact	4.48	0.6	damaging	0.21	damaging	4.09	23.70	deleterious	0.14	0.55	0.69	disease	0.81	disease	0.61	disease	0.69	disease	4	1	deleterious	0.07	neutral	5	deleterious	0.68	deleterious	-1.5	low_impact	-1.48	low_impact	3.04	high_impact	0.71	0.9	13.65	24.37	0.43	N	0.63	polymorphism	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7171	7171	T	G	MI.4598	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1268	423	L	R	cTa/cGa	-3.34	0	0	possibly_damaging	0.86	deleterious	0	neutral	2.39	deleterious	-4.52	neutral	-2.27	high_impact	4.48	0.57	damaging	0.15	damaging	4.22	23.90	deleterious	0.12	0.55	0.66	disease	0.93	disease	0.72	disease	0.8	disease	6	1	deleterious	0.07	neutral	5	deleterious	0.75	deleterious	-1.5	low_impact	-1.48	low_impact	3.04	high_impact	0.61	0.9	13.65	24.37	0.45	N	0.71	polymorphism	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7173	7173	A	G	MI.4599	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1270	424	T	A	Act/Gct	-1.26	0	0	probably_damaging	0.99	deleterious	0	neutral	2.68	neutral	-1.06	neutral	-2.27	high_impact	4.24	0.75	neutral	0.1	damaging	3.66	23.20	deleterious	0.48	0.55	0.29	neutral	0.64	disease	0.63	disease	0.58	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.69	deleterious	-2.64	low_impact	-1.48	low_impact	2.82	high_impact	0.74	0.9	NA	NA	0.38	N	0.69	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8546	8546	C	T	MI.46	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	20	7	A	V	gCt/gTt	-0.33	0	0	benign	0.06	deleterious	0	neutral	4.63	neutral	-1.01	neutral	-1.69	low_impact	1.36	0.88	neutral	0.59	neutral	2.72	20.90	deleterious	0.39	0.65	0.19	neutral	0.51	disease	0.5	neutral	0.53	disease	1	1	deleterious	0.47	deleterious	-2	neutral	0.17	neutral	0.38	medium_impact	-1.4	low_impact	0.07	medium_impact	0.63	0.9	9.29	10.06	0.48	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8743	8743	G	A	MI.460	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	217	73	V	M	Gta/Ata	-4.04	0	0	benign	0.01	neutral	0.34	neutral	4.22	neutral	-1.86	neutral	0.03	neutral_impact	0.26	0.9	neutral	0.87	neutral	-0.37	0.46	neutral	0.45	0.65	0.49	neutral	0.25	neutral	0.3	neutral	0.41	neutral	2	0.65	neutral	0.67	deleterious	-6	neutral	0.16	neutral	1.14	medium_impact	0.13	medium_impact	-0.88	medium_impact	0.77	0.9	25.22	18.16	0.44	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7173	7173	A	C	MI.4600	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1270	424	T	P	Act/Cct	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.24	deleterious	-2.73	high_impact	5.04	0.64	neutral	0.08	damaging	3.64	23.20	deleterious	0.14	0.55	0.72	disease	0.83	disease	0.8	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.73	0.9	NA	NA	0.73	P	0.92	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7173	7173	A	T	MI.4601	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1270	424	T	S	Act/Tct	-1.26	0	0	probably_damaging	0.99	deleterious	0	neutral	2.59	neutral	-2.69	neutral	-1.82	high_impact	4.7	0.74	neutral	0.08	damaging	3.47	23.00	deleterious	0.43	0.55	0.48	neutral	0.69	disease	0.66	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-1.48	low_impact	3.24	high_impact	0.78	0.9	NA	NA	0.54	N	0.79	disease_causing	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7174	7174	C	G	MI.4602	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1271	424	T	S	aCt/aGt	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	2.59	neutral	-2.69	neutral	-1.82	high_impact	4.7	0.74	neutral	0.08	damaging	3.62	23.20	deleterious	0.43	0.55	0.48	neutral	0.69	disease	0.66	disease	0.68	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-1.48	low_impact	3.24	high_impact	0.78	0.9	NA	NA	0.6	P	0.79	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7174	7174	C	T	MI.4603	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1271	424	T	I	aCt/aTt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.67	neutral	-1.13	deleterious	-2.73	high_impact	3.76	0.72	neutral	0.06	damaging	4.03	23.70	deleterious	0.35	0.55	0.44	neutral	0.85	disease	0.63	disease	0.52	disease	0	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.37	high_impact	0.77	0.9	NA	NA	0.46	N	0.92	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7174	7174	C	A	MI.4604	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1271	424	T	N	aCt/aAt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	2.57	deleterious	-3.56	neutral	-2.27	high_impact	4.35	0.69	neutral	0.06	damaging	3.87	23.50	deleterious	0.38	0.55	0.6	disease	0.82	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.92	high_impact	0.81	0.9	NA	NA	0.49	N	0.80	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7176	7176	T	C	MI.4605	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1273	425	F	L	Ttc/Ctc	-10.51	0	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-2.08	deleterious	-2.6	high_impact	4.72	0.58	damaging	0.19	damaging	4.23	23.90	deleterious	0.36	0.55	0.52	disease	0.8	disease	0.74	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.81	0.9	2.53	7.02	0.64	P	0.83	polymorphism	0.8	0.40	rs878929873	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7176	7176	T	G	MI.4606	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1273	425	F	V	Ttc/Gtc	-10.51	0	0	probably_damaging	1	deleterious	0	neutral	2.58	neutral	-1.26	deleterious	-3.03	high_impact	5.07	0.65	neutral	0.15	damaging	4.30	24.00	deleterious	0.24	0.55	0.56	disease	0.88	disease	0.77	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.58	high_impact	0.57	0.9	2.53	7.02	0.73	P	0.84	polymorphism	0.68	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7176	7176	T	A	MI.4607	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1273	425	F	I	Ttc/Atc	-10.51	0	0	probably_damaging	1	deleterious	0	neutral	2.53	neutral	-1.82	deleterious	-2.6	high_impact	4.38	0.72	neutral	0.18	damaging	4.59	24.40	deleterious	0.18	0.55	0.6	disease	0.87	disease	0.77	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.64	0.9	2.53	7.02	0.48	N	0.88	polymorphism	0.82	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7177	7177	T	C	MI.4608	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1274	425	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-2.07	deleterious	-3.46	high_impact	4.52	0.77	neutral	0.19	damaging	4.40	24.10	deleterious	0.22	0.55	0.49	neutral	0.84	disease	0.73	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.07	high_impact	0.54	0.9	2.53	7.02	0.53	P	0.84	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7177	7177	T	G	MI.4609	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1274	425	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.78	deleterious	-3.47	high_impact	5.07	0.68	neutral	0.16	damaging	4.27	23.90	deleterious	0.24	0.55	0.85	disease	0.88	disease	0.79	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.58	high_impact	0.39	0.9	2.53	7.02	0.73	P	0.91	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8743	8743	G	T	MI.461	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	217	73	V	L	Gta/Tta	-4.04	0	0	benign	0.01	neutral	0.6	neutral	4.43	neutral	0.21	neutral	-0.47	neutral_impact	-0.04	0.92	neutral	0.83	neutral	0.38	6.45	deleterious	0.48	0.65	0.25	neutral	0.42	neutral	0.32	neutral	0.44	neutral	1	0.39	neutral	0.8	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.39	medium_impact	-1.13	low_impact	0.72	0.9	25.22	18.16	0.28	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7177	7177	T	A	MI.4610	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1274	425	F	Y	tTc/tAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	2.46	neutral	-2.91	neutral	-1.3	high_impact	4.17	0.7	neutral	0.15	damaging	4.43	24.20	deleterious	0.22	0.55	0.55	disease	0.82	disease	0.73	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.75	high_impact	0.68	0.9	2.53	7.02	0.57	P	0.59	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7178	7178	C	G	MI.4611	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1275	425	F	L	ttC/ttG	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-2.08	deleterious	-2.6	high_impact	4.72	0.58	damaging	0.19	damaging	4.54	24.30	deleterious	0.36	0.55	0.52	disease	0.8	disease	0.74	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.81	0.9	2.53	7.02	0.72	P	0.83	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7178	7178	C	A	MI.4612	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1275	425	F	L	ttC/ttA	4.76	1	0	probably_damaging	1	deleterious	0	neutral	2.51	neutral	-2.08	deleterious	-2.6	high_impact	4.72	0.58	damaging	0.19	damaging	4.82	24.80	deleterious	0.36	0.55	0.52	disease	0.8	disease	0.74	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.26	high_impact	0.81	0.9	2.53	7.02	0.72	P	0.83	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7179	7179	T	G	MI.4613	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1276	426	F	V	Ttc/Gtc	-0.57	0.16	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-1.46	deleterious	-2.97	high_impact	4.92	0.73	neutral	0.07	damaging	4.19	23.80	deleterious	0.33	0.55	0.32	neutral	0.89	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.68	0.9	2.53	6.61	0.67	P	0.84	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7179	7179	T	A	MI.4614	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1276	426	F	I	Ttc/Atc	-0.57	0.16	0	probably_damaging	0.99	deleterious	0.03	neutral	2.68	neutral	-1.86	deleterious	-2.54	high_impact	3.88	0.75	neutral	0.07	damaging	4.49	24.30	deleterious	0.24	0.55	0.24	neutral	0.86	disease	0.67	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-0.65	medium_impact	2.48	high_impact	0.64	0.9	2.53	6.61	0.36	N	0.88	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7179	7179	T	C	MI.4615	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1276	426	F	L	Ttc/Ctc	-0.57	0.16	0	probably_damaging	0.98	deleterious	0	neutral	2.84	neutral	-0.97	deleterious	-2.54	medium_impact	2.69	0.75	neutral	0.06	damaging	4.15	23.80	deleterious	0.42	0.55	0.21	neutral	0.79	disease	0.64	disease	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-2.35	low_impact	-1.48	low_impact	1.39	medium_impact	0.81	0.9	2.53	6.61	0.32	N	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7180	7180	T	C	MI.4616	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1277	426	F	S	tTc/tCc	5.91	1	0	probably_damaging	1	deleterious	0.01	neutral	2.59	deleterious	-3.14	deleterious	-3.39	high_impact	4.38	0.76	neutral	0.08	damaging	4.42	24.20	deleterious	0.23	0.55	0.59	disease	0.85	disease	0.71	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-0.92	medium_impact	2.95	high_impact	0.59	0.9	2.53	6.61	0.5	N	0.84	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7180	7180	T	A	MI.4617	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1277	426	F	Y	tTc/tAc	5.91	1	0	probably_damaging	0.98	deleterious	0	neutral	2.62	neutral	-2.75	neutral	-1.27	high_impact	4.12	0.74	neutral	0.07	damaging	4.44	24.20	deleterious	0.32	0.55	0.43	neutral	0.82	disease	0.71	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.35	low_impact	-1.48	low_impact	2.71	high_impact	0.77	0.9	2.53	6.61	0.54	N	0.59	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7180	7180	T	G	MI.4618	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1277	426	F	C	tTc/tGc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.56	deleterious	-4.44	deleterious	-3.4	high_impact	4.92	0.75	neutral	0.06	damaging	4.29	24.00	deleterious	0.27	0.55	0.76	disease	0.89	disease	0.74	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.44	0.9	2.53	6.61	0.72	P	0.91	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7181	7181	C	G	MI.4619	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1278	426	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.84	neutral	-0.97	deleterious	-2.54	medium_impact	2.69	0.75	neutral	0.06	damaging	4.56	24.40	deleterious	0.42	0.55	0.21	neutral	0.79	disease	0.64	disease	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-2.35	low_impact	-1.48	low_impact	1.39	medium_impact	0.81	0.9	2.53	6.61	0.5	N	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8744	8744	T	C	MI.462	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	218	73	V	A	gTa/gCa	0.82	0	0	benign	0.03	neutral	0.51	neutral	4.26	neutral	-0.18	neutral	-0.91	neutral_impact	0.1	0.87	neutral	0.77	neutral	-0.20	1.08	neutral	0.37	0.65	0.39	neutral	0.21	neutral	0.35	neutral	0.37	neutral	3	0.46	neutral	0.74	deleterious	-6	neutral	0.16	neutral	0.68	medium_impact	0.3	medium_impact	-1.01	low_impact	0.57	0.9	25.22	18.16	0.28	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7181	7181	C	A	MI.4620	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1278	426	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.98	deleterious	0	neutral	2.84	neutral	-0.97	deleterious	-2.54	medium_impact	2.69	0.75	neutral	0.06	damaging	4.84	24.80	deleterious	0.42	0.55	0.21	neutral	0.79	disease	0.64	disease	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.73	deleterious	-2.35	low_impact	-1.48	low_impact	1.39	medium_impact	0.81	0.9	2.53	6.61	0.5	N	0.83	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7182	7182	C	A	MI.4621	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1279	427	P	T	Cca/Aca	-0.8	0.02	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	-2.01	deleterious	-3.4	high_impact	4.97	0.7	neutral	0.05	damaging	3.83	23.40	deleterious	0.25	0.55	0.6	disease	0.83	disease	0.69	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.49	high_impact	0.73	0.9	3.31	6.87	0.66	P	0.80	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7182	7182	C	G	MI.4622	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1279	427	P	A	Cca/Gca	-0.8	0.02	0	probably_damaging	1	deleterious	0	neutral	2.78	neutral	-1.4	deleterious	-3.4	high_impact	3.77	0.7	neutral	0.07	damaging	3.23	22.80	deleterious	0.21	0.55	0.25	neutral	0.71	disease	0.69	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	2.38	high_impact	0.77	0.9	3.31	6.87	0.34	N	0.76	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7182	7182	C	T	MI.4623	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1279	427	P	S	Cca/Tca	-0.8	0.02	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-1.28	deleterious	-3.4	high_impact	4	0.7	neutral	0.06	damaging	4.05	23.70	deleterious	0.27	0.55	0.6	disease	0.82	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.59	high_impact	0.39	0.9	3.31	6.87	0.31	N	0.85	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7183	7183	C	G	MI.4624	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1280	427	P	R	cCa/cGa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-3.5	deleterious	-3.84	high_impact	4.97	0.68	neutral	0.04	damaging	3.73	23.30	deleterious	0.18	0.55	0.73	disease	0.92	disease	0.8	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.49	high_impact	0.74	0.9	3.31	6.87	0.73	P	0.90	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7183	7183	C	A	MI.4625	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1280	427	P	Q	cCa/cAa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-3.86	deleterious	-3.41	high_impact	4.42	0.69	neutral	0.04	damaging	4.22	23.90	deleterious	0.16	0.55	0.73	disease	0.87	disease	0.72	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.60	0.9	3.31	6.87	0.53	P	0.82	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7183	7183	C	T	MI.4626	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1280	427	P	L	cCa/cTa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-2.24	deleterious	-4.26	high_impact	4.17	0.71	neutral	0.03	damaging	4.55	24.40	deleterious	0.22	0.55	0.43	neutral	0.87	disease	0.68	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.75	high_impact	0.76	0.9	3.31	6.87	0.51	N	0.87	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7185	7185	C	A	MI.4627	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1282	428	Q	K	Caa/Aaa	-8.89	0	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.37	neutral	-1.68	high_impact	4.88	0.61	neutral	0.04	damaging	4.17	23.80	deleterious	0.37	0.55	0.45	neutral	0.87	disease	0.76	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.41	high_impact	0.63	0.9	NA	NA	0.7	P	0.83	polymorphism	0.95	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7185	7185	C	G	MI.4628	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1282	428	Q	E	Caa/Gaa	-8.89	0	0	probably_damaging	0.98	deleterious	0	neutral	2.72	neutral	-2.56	neutral	-1.26	high_impact	4.88	0.57	damaging	0.06	damaging	3.28	22.80	deleterious	0.36	0.55	0.49	neutral	0.75	disease	0.72	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-2.35	low_impact	-1.48	low_impact	3.41	high_impact	0.61	0.9	NA	NA	0.63	P	0.72	polymorphism	0.97	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7186	7186	A	G	MI.4629	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1283	428	Q	R	cAa/cGa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.63	neutral	-1.68	high_impact	4.53	0.62	neutral	0.05	damaging	3.55	23.10	deleterious	0.36	0.55	0.53	disease	0.88	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.08	high_impact	0.54	0.9	NA	NA	0.54	P	0.76	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8744	8744	T	A	MI.463	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	218	73	V	E	gTa/gAa	0.82	0	0	benign	0.1	neutral	0.18	neutral	4.19	deleterious	-3.54	neutral	-2.49	medium_impact	2.52	0.88	neutral	0.5	neutral	2.84	21.60	deleterious	0.16	0.65	0.78	disease	0.81	disease	0.67	disease	0.79	disease	6	0.8	neutral	0.54	deleterious	-3	neutral	0.36	neutral	0.15	medium_impact	-0.08	medium_impact	1.06	medium_impact	0.61	0.9	25.22	18.16	0.35	N	0.73	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7186	7186	A	C	MI.4630	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1283	428	Q	P	cAa/cCa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.4	deleterious	-2.51	high_impact	4.88	0.55	damaging	0.05	damaging	3.44	23.00	deleterious	0.19	0.55	0.3	neutral	0.87	disease	0.76	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.41	high_impact	0.48	0.9	NA	NA	0.69	P	0.84	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7186	7186	A	T	MI.4631	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1283	428	Q	L	cAa/cTa	5.68	1	0	probably_damaging	1	neutral	0.12	neutral	3.08	neutral	0.03	deleterious	-2.93	high_impact	3.77	0.65	neutral	0.05	damaging	3.83	23.40	deleterious	0.21	0.55	0.32	neutral	0.85	disease	0.63	disease	0.68	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.79	deleterious	-3.58	low_impact	-0.29	medium_impact	2.38	high_impact	0.36	0.9	NA	NA	0.51	P	0.71	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7187	7187	A	C	MI.4632	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1284	428	Q	H	caA/caC	8.69	1	0	probably_damaging	1	deleterious	0.02	neutral	2.72	deleterious	-3.17	neutral	-2.09	medium_impact	3.06	0.64	neutral	0.04	damaging	3.54	23.10	deleterious	0.38	0.55	0.7	disease	0.79	disease	0.58	disease	0.54	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-0.75	medium_impact	1.73	medium_impact	0.64	0.9	NA	NA	0.45	N	0.70	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7187	7187	A	T	MI.4633	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1284	428	Q	H	caA/caT	8.69	1	0	probably_damaging	1	deleterious	0.02	neutral	2.72	deleterious	-3.17	neutral	-2.09	medium_impact	3.06	0.64	neutral	0.04	damaging	3.74	23.30	deleterious	0.38	0.55	0.7	disease	0.79	disease	0.58	disease	0.54	disease	1	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.58	low_impact	-0.75	medium_impact	1.73	medium_impact	0.64	0.9	NA	NA	0.46	N	0.70	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7188	7188	C	T	MI.4634	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1285	429	H	Y	Cac/Tac	1.52	1	0	probably_damaging	1	deleterious	0	neutral	2.82	neutral	-2.81	deleterious	-2.51	high_impact	5.04	0.6	neutral	0.04	damaging	3.84	23.40	deleterious	0.35	0.55	0.36	neutral	0.83	disease	0.77	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.46	0.9	6.82	7.99	0.69	P	0.72	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7188	7188	C	A	MI.4635	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1285	429	H	N	Cac/Aac	1.52	1	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.85	deleterious	-2.93	high_impact	5.04	0.58	damaging	0.04	damaging	4.16	23.80	deleterious	0.36	0.55	0.88	disease	0.8	disease	0.75	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.58	0.9	6.82	7.99	0.65	P	0.86	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7188	7188	C	G	MI.4636	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1285	429	H	D	Cac/Gac	1.52	1	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.95	deleterious	-3.77	high_impact	5.04	0.53	damaging	0.04	damaging	3.97	23.60	deleterious	0.25	0.55	0.93	disease	0.8	disease	0.81	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.54	0.9	6.82	7.99	0.64	P	0.97	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7189	7189	A	G	MI.4637	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1286	429	H	R	cAc/cGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.76	deleterious	-3.72	deleterious	-3.35	high_impact	5.04	0.62	neutral	0.04	damaging	2.99	22.20	deleterious	0.43	0.55	0.89	disease	0.85	disease	0.79	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.51	0.9	6.82	7.99	0.75	P	0.85	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7189	7189	A	C	MI.4638	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1286	429	H	P	cAc/cCc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-4.8	deleterious	-4.19	high_impact	4.7	0.54	damaging	0.04	damaging	3.25	22.80	deleterious	0.24	0.55	0.93	disease	0.84	disease	0.83	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.54	0.9	6.82	7.99	0.67	P	0.90	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7189	7189	A	T	MI.4639	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1286	429	H	L	cAc/cTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.88	neutral	-2.25	deleterious	-4.6	high_impact	4	0.66	neutral	0.03	damaging	3.78	23.40	deleterious	0.22	0.55	0.69	disease	0.85	disease	0.75	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.59	high_impact	0.43	0.9	6.82	7.99	0.54	P	0.92	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8744	8744	T	G	MI.464	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	218	73	V	G	gTa/gGa	0.82	0	0	benign	0.1	neutral	0.21	neutral	4.22	neutral	-1.96	deleterious	-3.17	low_impact	1.72	0.84	neutral	0.49	neutral	1.83	15.17	deleterious	0.24	0.65	0.35	neutral	0.62	disease	0.57	disease	0.72	disease	4	0.76	neutral	0.56	deleterious	-6	neutral	0.22	neutral	0.15	medium_impact	-0.03	medium_impact	0.38	medium_impact	0.64	0.9	25.22	18.16	0.35	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7190	7190	C	G	MI.4640	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1287	429	H	Q	caC/caG	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.48	deleterious	-3.35	high_impact	5.04	0.64	neutral	0.04	damaging	3.77	23.40	deleterious	0.38	0.55	0.88	disease	0.78	disease	0.72	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.64	0.9	6.82	7.99	0.73	P	0.83	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7190	7190	C	A	MI.4641	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1287	429	H	Q	caC/caA	6.84	1	0	probably_damaging	1	deleterious	0	neutral	2.75	deleterious	-3.48	deleterious	-3.35	high_impact	5.04	0.64	neutral	0.04	damaging	4.04	23.70	deleterious	0.38	0.55	0.88	disease	0.78	disease	0.72	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.64	0.9	6.82	7.99	0.74	P	0.83	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7191	7191	T	A	MI.4642	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1288	430	F	I	Ttt/Att	-6.35	0	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	-0.55	neutral	-2.35	high_impact	4.21	0.68	neutral	0.62	neutral	4.84	24.80	deleterious	0.26	0.55	0.28	neutral	0.85	disease	0.64	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.79	high_impact	0.55	0.9	2.53	6.62	0.46	N	0.88	polymorphism	0.52	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7191	7191	T	C	MI.4643	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1288	430	F	L	Ttt/Ctt	-6.35	0	0	probably_damaging	0.99	deleterious	0	neutral	2.81	neutral	-0.61	neutral	-2.33	medium_impact	3.41	0.47	damaging	0.59	neutral	4.38	24.10	deleterious	0.36	0.55	0.35	neutral	0.79	disease	0.55	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.05	high_impact	0.73	0.9	2.53	6.62	0.48	N	0.83	disease_causing	0.5	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7191	7191	T	G	MI.4644	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1288	430	F	V	Ttt/Gtt	-6.35	0	0	probably_damaging	1	deleterious	0	neutral	2.8	neutral	-0.64	deleterious	-2.74	high_impact	4.01	0.61	neutral	0.5	neutral	4.31	24.00	deleterious	0.31	0.55	0.17	neutral	0.88	disease	0.66	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.71	deleterious	-3.58	low_impact	-1.48	low_impact	2.6	high_impact	0.55	0.9	2.53	6.62	0.43	N	0.84	disease_causing	0.66	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7192	7192	T	C	MI.4645	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1289	430	F	S	tTt/tCt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.66	neutral	-2.57	deleterious	-3.17	high_impact	4.21	0.74	neutral	0.63	neutral	4.35	24.10	deleterious	0.28	0.55	0.55	disease	0.86	disease	0.63	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.79	high_impact	0.60	0.9	2.53	6.62	0.56	P	0.84	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7192	7192	T	A	MI.4646	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1289	430	F	Y	tTt/tAt	5.91	1	0	probably_damaging	0.99	neutral	0.06	neutral	2.69	neutral	-1.44	neutral	-1.2	medium_impact	3.38	0.68	neutral	0.49	neutral	4.38	24.10	deleterious	0.38	0.55	0.43	neutral	0.78	disease	0.57	disease	0.52	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.76	deleterious	-2.64	low_impact	-0.47	medium_impact	2.02	high_impact	0.64	0.9	2.53	6.62	0.62	P	0.59	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7192	7192	T	G	MI.4647	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1289	430	F	C	tTt/tGt	5.91	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-3.92	deleterious	-3.18	high_impact	4.91	0.66	neutral	0.51	neutral	4.26	23.90	deleterious	0.27	0.55	0.73	disease	0.88	disease	0.66	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.40	0.9	2.53	6.62	0.71	P	0.91	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7193	7193	T	A	MI.4648	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1290	430	F	L	ttT/ttA	5.91	1	0	probably_damaging	0.99	deleterious	0	neutral	2.81	neutral	-0.61	neutral	-2.33	medium_impact	3.41	0.47	damaging	0.59	neutral	4.70	24.60	deleterious	0.36	0.55	0.35	neutral	0.79	disease	0.55	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.05	high_impact	0.73	0.9	2.53	6.62	0.64	P	0.83	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7193	7193	T	G	MI.4649	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1290	430	F	L	ttT/ttG	5.91	1	0	probably_damaging	0.99	deleterious	0	neutral	2.81	neutral	-0.61	neutral	-2.33	medium_impact	3.41	0.47	damaging	0.59	neutral	4.56	24.40	deleterious	0.36	0.55	0.35	neutral	0.79	disease	0.55	disease	0.68	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.05	high_impact	0.73	0.9	2.53	6.62	0.64	P	0.83	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8746	8746	T	G	MI.465	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	220	74	S	A	Tcc/Gcc	-9.36	0	0	benign	0.16	neutral	0.11	neutral	4.34	neutral	-0.93	neutral	-2.33	low_impact	1.49	0.87	neutral	0.66	neutral	0.57	7.93	deleterious	0.34	0.65	0.4	neutral	0.55	disease	0.47	neutral	0.44	neutral	1	0.87	neutral	0.48	deleterious	-6	neutral	0.24	neutral	-0.07	medium_impact	-0.22	medium_impact	0.18	medium_impact	0.72	0.9	16.81	15.96	0.42	N	0.45	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7194	7194	C	G	MI.4650	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1291	431	L	V	Ctc/Gtc	-0.1	0	0	probably_damaging	0.98	deleterious	0	neutral	2.63	neutral	-1.74	neutral	-1.23	high_impact	3.9	0.45	damaging	0.44	neutral	3.61	23.20	deleterious	0.42	0.55	0.42	neutral	0.71	disease	0.63	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.35	low_impact	-1.48	low_impact	2.5	high_impact	0.58	0.9	2.53	6.78	0.5	N	0.66	disease_causing	0.88	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7194	7194	C	T	MI.4651	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1291	431	L	F	Ctc/Ttc	-0.1	0	0	probably_damaging	1	neutral	0.07	neutral	2.52	deleterious	-3.68	neutral	-1.64	high_impact	4.1	0.36	damaging	0.37	neutral	4.15	23.80	deleterious	0.35	0.55	0.68	disease	0.76	disease	0.69	disease	0.7	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-3.58	low_impact	-0.43	medium_impact	2.69	high_impact	0.58	0.9	2.53	6.78	0.6	P	0.87	disease_causing	0.97	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7194	7194	C	A	MI.4652	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1291	431	L	I	Ctc/Atc	-0.1	0	0	probably_damaging	0.99	deleterious	0	neutral	2.6	neutral	-2.07	neutral	-0.82	high_impact	4.3	0.5	damaging	0.52	neutral	4.28	24.00	deleterious	0.33	0.55	0.54	disease	0.72	disease	0.69	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.87	high_impact	0.75	0.9	2.53	6.78	0.53	P	0.54	disease_causing	0.81	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7195	7195	T	G	MI.4653	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1292	431	L	R	cTc/cGc	-0.1	0.01	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.34	neutral	-2.47	high_impact	5	0.53	damaging	0.31	neutral	4.30	24.00	deleterious	0.18	0.55	0.63	disease	0.9	disease	0.8	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.62	0.9	2.53	6.78	0.72	P	0.90	disease_causing	0.95	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7195	7195	T	C	MI.4654	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1292	431	L	P	cTc/cCc	-0.1	0.01	0	probably_damaging	1	deleterious	0	neutral	2.5	deleterious	-4.7	deleterious	-2.88	high_impact	5	0.44	damaging	0.36	neutral	4.05	23.70	deleterious	0.15	0.55	0.77	disease	0.83	disease	0.79	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.61	0.9	2.53	6.78	0.76	P	0.83	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7195	7195	T	A	MI.4655	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1292	431	L	H	cTc/cAc	-0.1	0.01	0	probably_damaging	1	deleterious	0	neutral	2.49	deleterious	-5	deleterious	-2.88	high_impact	5	0.54	damaging	0.35	neutral	4.19	23.90	deleterious	0.19	0.55	0.76	disease	0.86	disease	0.77	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.59	0.9	2.53	6.78	0.73	P	0.83	disease_causing	0.91	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7197	7197	G	A	MI.4656	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1294	432	G	S	Ggc/Agc	-1.95	0	0	probably_damaging	1	deleterious	0.01	neutral	-0.39	deleterious	-9.76	neutral	-2.44	high_impact	4.51	0.7	neutral	0.1	damaging	4.36	24.10	deleterious	0.23	0.55	0.71	disease	0.77	disease	0.65	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-0.92	medium_impact	3.07	high_impact	0.71	0.9	2.14	6.59	0.42	N	0.73	polymorphism	0.61	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7197	7197	G	C	MI.4657	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1294	432	G	R	Ggc/Cgc	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	-0.4	deleterious	-11.39	deleterious	-3.27	high_impact	5.06	0.61	neutral	0.07	damaging	4.07	23.70	deleterious	0.19	0.55	0.91	disease	0.86	disease	0.79	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.57	high_impact	0.78	0.9	2.14	6.59	0.59	P	0.95	disease_causing	0.58	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7197	7197	G	T	MI.4658	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1294	432	G	C	Ggc/Tgc	-1.95	0	0	probably_damaging	1	deleterious	0	neutral	-0.4	deleterious	-12.88	deleterious	-3.68	high_impact	5.06	0.59	damaging	0.08	damaging	4.32	24.00	deleterious	0.16	0.55	0.91	disease	0.87	disease	0.69	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.57	high_impact	0.36	0.9	2.14	6.59	0.53	P	0.98	disease_causing	0.73	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7198	7198	G	C	MI.4659	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1295	432	G	A	gGc/gCc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	-0.37	deleterious	-8.56	neutral	-2.44	high_impact	4.71	0.79	neutral	0.13	damaging	3.35	22.90	deleterious	0.24	0.55	0.66	disease	0.68	disease	0.63	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.25	high_impact	0.59	0.9	2.14	6.59	0.64	P	0.64	disease_causing	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8746	8746	T	A	MI.466	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	220	74	S	T	Tcc/Acc	-9.36	0	0	benign	0.21	neutral	0.08	neutral	4.63	neutral	1.62	neutral	-2.13	low_impact	1.49	0.88	neutral	0.76	neutral	0.72	8.95	deleterious	0.34	0.65	0.28	neutral	0.58	disease	0.42	neutral	0.43	neutral	1	0.91	neutral	0.44	neutral	-6	neutral	0.27	neutral	-0.21	medium_impact	-0.31	medium_impact	0.18	medium_impact	0.78	0.9	16.81	15.96	0.43	N	0.67	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7198	7198	G	A	MI.4660	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1295	432	G	D	gGc/gAc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	-0.4	deleterious	-10.55	deleterious	-2.86	high_impact	5.06	0.59	damaging	0.08	damaging	4.02	23.60	deleterious	0.17	0.55	0.9	disease	0.86	disease	0.78	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.57	high_impact	0.35	0.9	2.14	6.59	0.67	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	COSM6716188	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7198	7198	G	T	MI.4661	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1295	432	G	V	gGc/gTc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	-0.4	deleterious	-12.14	deleterious	-3.67	high_impact	4.51	0.61	neutral	0.09	damaging	3.98	23.60	deleterious	0.15	0.55	0.39	neutral	0.86	disease	0.69	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.07	high_impact	0.37	0.9	2.14	6.59	0.38	N	0.93	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7200	7200	C	G	MI.4662	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1297	433	L	V	Cta/Gta	-20	0	0	probably_damaging	0.99	deleterious	0.03	neutral	2.67	neutral	-1.96	neutral	-1.21	medium_impact	3.25	0.53	damaging	0.07	damaging	3.61	23.20	deleterious	0.41	0.55	0.33	neutral	0.65	disease	0.42	neutral	0.48	neutral	0	1	deleterious	0.02	neutral	5	deleterious	0.72	deleterious	-2.64	low_impact	-0.65	medium_impact	1.9	medium_impact	0.58	0.9	3.12	6.95	0.3	N	0.66	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7200	7200	C	A	MI.4663	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1297	433	L	M	Cta/Ata	-20	0	0	probably_damaging	1	neutral	0.06	neutral	2.49	neutral	-2.52	neutral	-0.8	medium_impact	2.94	0.58	damaging	0.08	damaging	3.95	23.60	deleterious	0.26	0.55	0.51	disease	0.49	neutral	0.37	neutral	0.44	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.47	medium_impact	1.62	medium_impact	0.69	0.9	3.12	6.95	0.32	N	0.59	polymorphism	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7201	7201	T	C	MI.4664	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1298	433	L	P	cTa/cCa	-0.57	0	0	probably_damaging	1	deleterious	0	neutral	2.45	deleterious	-5.24	deleterious	-2.84	high_impact	4.87	0.45	damaging	0.05	damaging	4.13	23.80	deleterious	0.2	0.55	0.78	disease	0.8	disease	0.57	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.4	high_impact	0.62	0.9	3.12	6.95	0.56	P	0.83	disease_causing	0.97	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7201	7201	T	G	MI.4665	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1298	433	L	R	cTa/cGa	-0.57	0	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-4.43	neutral	-2.43	high_impact	4.32	0.57	damaging	0.04	damaging	4.41	24.20	deleterious	0.19	0.55	0.7	disease	0.88	disease	0.7	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.89	high_impact	0.60	0.9	3.12	6.95	0.36	N	0.90	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7201	7201	T	A	MI.4666	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1298	433	L	Q	cTa/cAa	-0.57	0	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-4.82	neutral	-2.42	high_impact	4.87	0.58	damaging	0.05	damaging	4.29	24.00	deleterious	0.2	0.55	0.72	disease	0.81	disease	0.58	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.4	high_impact	0.63	0.9	3.12	6.95	0.62	P	0.82	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7203	7203	T	C	MI.4667	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1300	434	S	P	Tcc/Ccc	-1.95	0	0	probably_damaging	1	deleterious	0.02	neutral	2.75	neutral	-2.15	neutral	-1.18	high_impact	3.84	0.39	damaging	0.08	damaging	4.15	23.80	deleterious	0.26	0.55	0.55	disease	0.87	disease	0.47	neutral	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-0.75	medium_impact	2.45	high_impact	0.48	0.9	9.75	9.22	0.44	N	0.62	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7203	7203	T	G	MI.4668	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1300	434	S	A	Tcc/Gcc	-1.95	0	0	probably_damaging	0.99	neutral	1	neutral	2.83	neutral	0.47	neutral	0.02	neutral_impact	0.02	0.73	neutral	0.91	neutral	1.16	11.51	neutral	0.31	0.55	0.17	neutral	0.13	neutral	0.12	neutral	0.25	neutral	5	0.99	deleterious	0.51	deleterious	-2	neutral	0.64	deleterious	-2.64	low_impact	1.86	high_impact	-1.08	low_impact	0.54	0.9	9.75	9.22	0.35	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7203	7203	T	A	MI.4669	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1300	434	S	T	Tcc/Acc	-1.95	0	0	probably_damaging	0.99	neutral	0.18	neutral	2.81	neutral	-0.04	neutral	-0.57	medium_impact	2.39	0.58	damaging	0.16	damaging	3.88	23.50	deleterious	0.32	0.55	0.34	neutral	0.55	disease	0.18	neutral	0.49	neutral	0	0.99	deleterious	0.1	neutral	1	deleterious	0.66	deleterious	-2.64	low_impact	-0.17	medium_impact	1.11	medium_impact	0.70	0.9	9.75	9.22	0.49	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8746	8746	T	C	MI.467	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	220	74	S	P	Tcc/Ccc	-9.36	0	0	possibly_damaging	0.53	deleterious	0.02	neutral	4.26	deleterious	-4.3	deleterious	-4.26	medium_impact	2.99	0.66	neutral	0.41	neutral	3.52	23.10	deleterious	0.15	0.65	0.86	disease	0.9	disease	0.75	disease	0.79	disease	6	0.98	neutral	0.25	neutral	4	deleterious	0.73	deleterious	-0.81	medium_impact	-0.66	medium_impact	1.47	medium_impact	0.63	0.9	16.81	15.96	0.3	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7204	7204	C	G	MI.4670	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1301	434	S	C	tCc/tGc	1.98	0.98	0	probably_damaging	1	neutral	0.12	neutral	2.77	neutral	-1.36	neutral	-1.07	medium_impact	3.03	0.51	damaging	0.1	damaging	3.73	23.30	deleterious	0.29	0.55	0.77	disease	0.8	disease	0.49	neutral	0.7	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.29	medium_impact	1.7	medium_impact	0.52	0.9	9.75	9.22	0.44	N	0.41	polymorphism	0.81	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7204	7204	C	T	MI.4671	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1301	434	S	F	tCc/tTc	1.98	0.98	0	probably_damaging	1	deleterious	0.01	neutral	2.79	neutral	-0.39	neutral	-1.55	medium_impact	3.48	0.48	damaging	0.08	damaging	4.35	24.10	deleterious	0.25	0.55	0.63	disease	0.81	disease	0.55	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-0.92	medium_impact	2.11	high_impact	0.38	0.9	9.75	9.22	0.41	N	0.82	polymorphism	0.59	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7204	7204	C	A	MI.4672	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1301	434	S	Y	tCc/tAc	1.98	0.98	0	probably_damaging	1	deleterious	0.01	neutral	2.83	neutral	0.45	neutral	-1.46	medium_impact	3.14	0.52	damaging	0.09	damaging	4.31	24.00	deleterious	0.29	0.55	0.6	disease	0.81	disease	0.54	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-0.92	medium_impact	1.8	medium_impact	0.63	0.9	9.75	9.22	0.38	N	0.91	polymorphism	0.71	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7206	7206	G	C	MI.4673	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1303	435	G	R	Gga/Cga	-10.51	0	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-4.1	deleterious	-3.22	high_impact	5.01	0.41	damaging	0.01	damaging	4.18	23.80	deleterious	0.21	0.55	0.83	disease	0.84	disease	0.82	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.53	high_impact	0.80	0.9	2.73	6.63	0.61	P	0.95	polymorphism	0.76	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7206	7206	G	T	MI.4674	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1303	435	G	W	Gga/Tga	-10.51	0	0	probably_damaging	1	deleterious	0	neutral	2.38	deleterious	-7.14	deleterious	-3.22	high_impact	4.66	0.38	damaging	0.02	damaging	4.62	24.50	deleterious	0.17	0.55	0.94	disease	0.84	disease	0.76	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.36	0.9	2.73	6.63	0.44	N	0.83	polymorphism	0.66	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7207	7207	G	A	MI.4675	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1304	435	G	E	gGa/gAa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.46	deleterious	-3.21	deleterious	-3.21	high_impact	4.66	0.33	damaging	0.02	damaging	4.08	23.70	deleterious	0.23	0.55	0.8	disease	0.79	disease	0.81	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.62	0.9	2.73	6.63	0.76	P	0.93	disease_causing	1	0.47	.	.	.	.	.	.	COSM1319396	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7207	7207	G	C	MI.4676	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1304	435	G	A	gGa/gCa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.43	deleterious	-3.87	neutral	-2.4	high_impact	4.46	0.56	damaging	0.04	damaging	3.32	22.90	deleterious	0.27	0.55	0.63	disease	0.69	disease	0.68	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.02	high_impact	0.59	0.9	2.73	6.63	0.51	P	0.64	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7207	7207	G	T	MI.4677	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1304	435	G	V	gGa/gTa	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.39	deleterious	-5.45	deleterious	-3.62	high_impact	3.73	0.45	damaging	0.02	damaging	3.94	23.50	deleterious	0.15	0.55	0.62	disease	0.86	disease	0.74	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.35	high_impact	0.37	0.9	2.73	6.63	0.51	N	0.93	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7209	7209	A	G	MI.4678	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1306	436	M	V	Atg/Gtg	-11.21	0	0	probably_damaging	0.94	deleterious	0	neutral	2.64	neutral	-1.3	neutral	-1.57	high_impact	4.28	0.62	neutral	0.12	damaging	3.00	22.20	deleterious	0.35	0.55	0.54	disease	0.73	disease	0.71	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.75	deleterious	-1.88	low_impact	-1.48	low_impact	2.85	high_impact	0.31	0.9	2.53	6.68	0.37	N	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7209	7209	A	C	MI.4679	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1306	436	M	L	Atg/Ctg	-11.21	0	0	probably_damaging	0.91	neutral	0.09	neutral	2.67	neutral	-1.4	neutral	-1.17	medium_impact	3.04	0.67	neutral	0.1	damaging	3.60	23.20	deleterious	0.33	0.55	0.26	neutral	0.62	disease	0.6	disease	0.47	neutral	1	0.97	neutral	0.09	neutral	1	deleterious	0.64	deleterious	-1.7	low_impact	-0.37	medium_impact	1.71	medium_impact	0.26	0.9	2.53	6.68	0.33	N	0.61	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8747	8747	C	T	MI.468	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	221	74	S	F	tCc/tTc	2.21	0.97	0	benign	0.22	neutral	0.07	neutral	4.36	deleterious	-4.4	deleterious	-5.13	medium_impact	3.34	0.68	neutral	0.39	neutral	2.28	18.02	deleterious	0.13	0.65	0.51	disease	0.92	disease	0.66	disease	0.75	disease	5	0.92	neutral	0.43	neutral	-3	neutral	0.36	neutral	-0.23	medium_impact	-0.34	medium_impact	1.77	medium_impact	0.46	0.9	16.81	15.96	0.45	N	1.00	disease_causing	0.96	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7209	7209	A	T	MI.4680	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1306	436	M	L	Atg/Ttg	-11.21	0	0	probably_damaging	0.91	neutral	0.09	neutral	2.67	neutral	-1.4	neutral	-1.17	medium_impact	3.04	0.67	neutral	0.1	damaging	3.63	23.20	deleterious	0.33	0.55	0.26	neutral	0.62	disease	0.6	disease	0.47	neutral	1	0.97	neutral	0.09	neutral	1	deleterious	0.64	deleterious	-1.7	low_impact	-0.37	medium_impact	1.71	medium_impact	0.26	0.9	2.53	6.68	0.33	N	0.61	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7210	7210	T	C	MI.4681	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1307	436	M	T	aTg/aCg	6.84	1	0	probably_damaging	0.99	deleterious	0	neutral	2.54	neutral	-2.76	neutral	-2.35	high_impact	4.62	0.7	neutral	0.13	damaging	3.24	22.80	deleterious	0.31	0.55	0.71	disease	0.79	disease	0.71	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.17	high_impact	0.15	0.9	2.53	6.68	0.53	P	0.79	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7210	7210	T	A	MI.4682	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1307	436	M	K	aTg/aAg	6.84	1	0	probably_damaging	0.97	deleterious	0	neutral	2.5	deleterious	-3.67	neutral	-2.36	high_impact	4.42	0.62	neutral	0.1	damaging	4.37	24.10	deleterious	0.21	0.55	0.83	disease	0.79	disease	0.72	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-2.18	low_impact	-1.48	low_impact	2.98	high_impact	0.21	0.9	2.53	6.68	0.55	P	0.93	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7211	7211	G	C	MI.4683	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1308	436	M	I	atG/atC	7.53	1	0	probably_damaging	0.96	deleterious	0	neutral	2.55	neutral	-1.91	neutral	-1.56	high_impact	4.28	0.57	damaging	0.15	damaging	3.76	23.30	deleterious	0.36	0.55	0.53	disease	0.69	disease	0.61	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.76	deleterious	-2.06	low_impact	-1.48	low_impact	2.85	high_impact	0.33	0.9	2.53	6.68	0.49	P	0.87	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7211	7211	G	T	MI.4684	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1308	436	M	I	atG/atT	7.53	1	0	probably_damaging	0.96	deleterious	0	neutral	2.55	neutral	-1.91	neutral	-1.56	high_impact	4.28	0.57	damaging	0.15	damaging	3.89	23.50	deleterious	0.36	0.55	0.53	disease	0.69	disease	0.61	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.76	deleterious	-2.06	low_impact	-1.48	low_impact	2.85	high_impact	0.33	0.9	2.53	6.68	0.5	P	0.87	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7212	7212	C	G	MI.4685	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1309	437	P	A	Ccc/Gcc	-0.33	0.28	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.21	deleterious	-3.05	high_impact	4.68	0.66	neutral	0.06	damaging	3.30	22.90	deleterious	0.36	0.55	0.63	disease	0.66	disease	0.69	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.55	0.9	2.92	6.71	0.49	N	0.76	disease_causing	0.93	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7212	7212	C	T	MI.4686	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1309	437	P	S	Ccc/Tcc	-0.33	0.28	0	probably_damaging	1	deleterious	0	neutral	2.68	deleterious	-3.55	deleterious	-3.05	high_impact	4.68	0.65	neutral	0.03	damaging	4.09	23.70	deleterious	0.41	0.55	0.67	disease	0.78	disease	0.67	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.28	0.9	2.92	6.71	0.49	N	0.85	disease_causing	0.96	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7212	7212	C	A	MI.4687	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1309	437	P	T	Ccc/Acc	-0.33	0.28	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	-2.69	deleterious	-3.05	high_impact	4.22	0.66	neutral	0.04	damaging	3.88	23.50	deleterious	0.36	0.55	0.59	disease	0.79	disease	0.68	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.8	high_impact	0.54	0.9	2.92	6.71	0.31	N	0.80	disease_causing	0.95	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7213	7213	C	A	MI.4688	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1310	437	P	H	cCc/cAc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-4.72	deleterious	-3.44	high_impact	5.03	0.65	neutral	0.02	damaging	4.17	23.80	deleterious	0.3	0.55	0.94	disease	0.81	disease	0.77	disease	0.85	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.55	high_impact	0.48	0.9	2.92	6.71	0.72	P	0.81	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7213	7213	C	G	MI.4689	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1310	437	P	R	cCc/cGc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-4.01	deleterious	-3.44	high_impact	4.68	0.62	neutral	0.03	damaging	3.77	23.40	deleterious	0.27	0.55	0.9	disease	0.85	disease	0.78	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.37	0.9	2.92	6.71	0.65	P	0.90	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8747	8747	C	G	MI.469	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	221	74	S	C	tCc/tGc	2.21	0.97	0	possibly_damaging	0.78	deleterious	0	neutral	4.25	deleterious	-4.93	deleterious	-4.22	medium_impact	2.52	0.71	neutral	0.37	neutral	3.22	22.70	deleterious	0.16	0.65	0.86	disease	0.86	disease	0.58	disease	0.72	disease	4	1	deleterious	0.11	neutral	4	deleterious	0.74	deleterious	-1.28	low_impact	-1.4	low_impact	1.06	medium_impact	0.64	0.9	16.81	15.96	0.4	N	0.99	disease_causing	0.88	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7213	7213	C	T	MI.4690	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1310	437	P	L	cCc/cTc	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.86	neutral	-2.5	deleterious	-3.82	high_impact	4.68	0.66	neutral	0.02	damaging	4.62	24.50	deleterious	0.35	0.55	0.89	disease	0.82	disease	0.66	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.22	high_impact	0.84	0.9	2.92	6.71	0.61	P	0.87	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7215	7215	C	T	MI.4691	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1312	438	R	W	Cga/Tga	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.1	deleterious	-10.74	deleterious	-3.01	high_impact	5.05	0.5	damaging	0.03	damaging	5.41	26.00	deleterious	0.2	0.55	0.97	disease	0.83	disease	0.77	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.83	0.9	2.34	6.74	0.55	P	1.00	polymorphism	0.71	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7215	7215	C	G	MI.4692	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1312	438	R	G	Cga/Gga	-3.57	0	0	probably_damaging	1	deleterious	0	neutral	2.11	deleterious	-8.13	deleterious	-2.63	high_impact	5.05	0.56	damaging	0.04	damaging	4.43	24.20	deleterious	0.22	0.55	0.83	disease	0.72	disease	0.76	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.51	0.9	2.34	6.74	0.62	P	0.92	polymorphism	0.88	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7216	7216	G	C	MI.4693	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1313	438	R	P	cGa/cCa	2.9	0.98	0	probably_damaging	1	deleterious	0	neutral	2.11	deleterious	-8.81	deleterious	-2.63	high_impact	4.7	0.44	damaging	0.03	damaging	4.45	24.20	deleterious	0.19	0.55	0.89	disease	0.8	disease	0.72	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.49	0.9	2.34	6.74	0.6	P	0.99	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7216	7216	G	A	MI.4694	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1313	438	R	Q	cGa/cAa	2.9	0.98	0	probably_damaging	1	deleterious	0	neutral	2.17	deleterious	-6.93	neutral	-1.5	high_impact	5.05	0.57	damaging	0.02	damaging	4.70	24.60	deleterious	0.26	0.55	0.8	disease	0.75	disease	0.77	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.69	0.9	2.34	6.74	0.7	P	0.99	disease_causing	1	0.25	.	.	.	.	.	.	COSM1155671	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7216	7216	G	T	MI.4695	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1313	438	R	L	cGa/cTa	2.9	0.98	0	probably_damaging	1	deleterious	0	neutral	2.18	deleterious	-8.05	deleterious	-2.63	high_impact	4.7	0.6	neutral	0.02	damaging	4.53	24.30	deleterious	0.2	0.55	0.86	disease	0.88	disease	0.74	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.24	high_impact	0.33	0.9	2.34	6.74	0.62	P	0.99	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7218	7218	C	A	MI.4696	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1315	439	R	S	Cgt/Agt	-0.33	0.41	0	probably_damaging	1	deleterious	0	neutral	2.35	deleterious	-6.75	neutral	-2.21	high_impact	4.13	0.63	neutral	0.29	neutral	4.78	24.70	deleterious	0.36	0.55	0.78	disease	0.79	disease	0.75	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.71	high_impact	0.57	0.9	1.36	6.8	0.4	N	0.80	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7218	7218	C	G	MI.4697	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1315	439	R	G	Cgt/Ggt	-0.33	0.41	0	probably_damaging	1	deleterious	0	neutral	2.33	deleterious	-6.89	deleterious	-2.59	high_impact	5.04	0.55	damaging	0.31	neutral	4.38	24.10	deleterious	0.33	0.55	0.85	disease	0.72	disease	0.76	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.50	0.9	1.36	6.8	0.65	P	0.92	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7218	7218	C	T	MI.4698	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1315	439	R	C	Cgt/Tgt	-0.33	0.41	0	probably_damaging	1	deleterious	0	neutral	2.28	deleterious	-9.63	deleterious	-2.96	high_impact	5.04	0.54	damaging	0.15	damaging	5.21	25.60	deleterious	0.23	0.55	0.96	disease	0.82	disease	0.76	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.72	0.9	1.36	6.8	0.62	P	1.00	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7219	7219	G	C	MI.4699	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1316	439	R	P	cGt/cCt	3.6	0.99	0	probably_damaging	1	deleterious	0	neutral	2.32	deleterious	-8.01	deleterious	-2.59	high_impact	4.69	0.48	damaging	0.21	damaging	4.42	24.20	deleterious	0.25	0.55	0.89	disease	0.81	disease	0.75	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.23	high_impact	0.54	0.9	1.36	6.8	0.61	P	0.99	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8546	8546	C	G	MI.47	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	20	7	A	G	gCt/gGt	-0.33	0	0	benign	0.06	neutral	0.14	neutral	4.65	neutral	-1.04	neutral	-1.29	low_impact	1.7	0.82	neutral	0.51	neutral	1.63	14.00	neutral	0.38	0.65	0.5	neutral	0.45	neutral	0.46	neutral	0.34	neutral	3	0.85	neutral	0.54	deleterious	-6	neutral	0.29	neutral	0.38	medium_impact	-0.15	medium_impact	0.36	medium_impact	0.80	0.9	9.29	10.06	0.44	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8747	8747	C	A	MI.470	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	221	74	S	Y	tCc/tAc	2.21	0.97	0	benign	0.22	deleterious	0.01	neutral	4.27	deleterious	-4.84	deleterious	-5.13	high_impact	3.8	0.72	neutral	0.37	neutral	2.28	18.02	deleterious	0.14	0.65	0.82	disease	0.91	disease	0.66	disease	0.75	disease	5	0.99	deleterious	0.4	neutral	2	deleterious	0.39	neutral	-0.23	medium_impact	-0.84	medium_impact	2.16	high_impact	0.59	0.9	16.81	15.96	0.43	N	1.00	disease_causing	0.93	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7219	7219	G	A	MI.4700	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1316	439	R	H	cGt/cAt	3.6	0.99	0	probably_damaging	1	deleterious	0	neutral	2.3	deleterious	-6.46	neutral	-1.85	high_impact	5.04	0.46	damaging	0.14	damaging	4.61	24.40	deleterious	0.36	0.55	0.84	disease	0.74	disease	0.58	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.56	high_impact	0.69	0.9	1.36	6.8	0.7	P	0.98	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7219	7219	G	T	MI.4701	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1316	439	R	L	cGt/cTt	3.6	0.99	0	probably_damaging	0.99	deleterious	0	neutral	2.3	deleterious	-7.02	deleterious	-2.59	high_impact	5.04	0.57	damaging	0.27	damaging	4.52	24.30	deleterious	0.31	0.55	0.84	disease	0.88	disease	0.73	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.64	low_impact	-1.48	low_impact	3.56	high_impact	0.34	0.9	1.36	6.8	0.71	P	0.99	disease_causing	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7221	7221	T	A	MI.4702	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1318	440	Y	N	Tac/Aac	-4.04	0	0	benign	0.4	deleterious	0	neutral	2.8	deleterious	-4.61	deleterious	-3.28	high_impact	4.88	0.55	damaging	0.12	damaging	4.25	23.90	deleterious	0.41	0.55	0.76	disease	0.83	disease	0.69	disease	0.73	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.52	deleterious	-0.59	medium_impact	-1.48	low_impact	3.41	high_impact	0.20	0.9	NA	NA	0.57	P	0.94	polymorphism	0.67	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7221	7221	T	C	MI.4703	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1318	440	Y	H	Tac/Cac	-4.04	0	0	possibly_damaging	0.87	deleterious	0	neutral	2.81	deleterious	-4.46	neutral	-1.82	high_impact	4.88	0.63	neutral	0.1	damaging	3.80	23.40	deleterious	0.54	0.6	0.79	disease	0.72	disease	0.71	disease	0.75	disease	5	1	deleterious	0.07	neutral	5	deleterious	0.72	deleterious	-1.53	low_impact	-1.48	low_impact	3.41	high_impact	0.26	0.9	NA	NA	0.67	P	0.61	polymorphism	0.96	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7221	7221	T	G	MI.4704	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1318	440	Y	D	Tac/Gac	-4.04	0	0	benign	0.02	deleterious	0	neutral	2.81	deleterious	-4.78	deleterious	-3.65	high_impact	4.88	0.6	damaging	0.11	damaging	4.17	23.80	deleterious	0.31	0.55	0.84	disease	0.84	disease	0.71	disease	0.79	disease	6	1	deleterious	0.49	deleterious	2	deleterious	0.31	neutral	0.83	medium_impact	-1.48	low_impact	3.41	high_impact	0.28	0.9	NA	NA	0.58	P	0.98	polymorphism	0.74	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7222	7222	A	G	MI.4705	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1319	440	Y	C	tAc/tGc	5.68	1	0	probably_damaging	0.94	deleterious	0	neutral	2.79	deleterious	-6.1	deleterious	-3.29	high_impact	4.08	0.58	damaging	0.09	damaging	3.77	23.40	deleterious	0.43	0.55	0.77	disease	0.82	disease	0.61	disease	0.7	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-1.88	low_impact	-1.48	low_impact	2.67	high_impact	0.08	0.9	NA	NA	0.41	N	0.89	disease_causing	1	0.34	.	.	.	.	.	muscle- pt with weakness, peripheral neuropathy, ptosis	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7222	7222	A	T	MI.4706	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1319	440	Y	F	tAc/tTc	5.68	1	0	benign	0.43	deleterious	0.01	neutral	2.87	neutral	-2.44	neutral	-1.46	high_impact	4.88	0.51	damaging	0.12	damaging	3.62	23.20	deleterious	0.37	0.55	0.59	disease	0.71	disease	0.64	disease	0.67	disease	3	0.99	deleterious	0.29	neutral	2	deleterious	0.52	deleterious	-0.64	medium_impact	-0.92	medium_impact	3.41	high_impact	0.26	0.9	NA	NA	0.67	P	0.50	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7222	7222	A	C	MI.4707	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1319	440	Y	S	tAc/tCc	5.68	1	0	benign	0.4	deleterious	0	neutral	2.83	deleterious	-4.11	deleterious	-3.28	high_impact	4.88	0.58	damaging	0.18	damaging	3.91	23.50	deleterious	0.3	0.55	0.61	disease	0.8	disease	0.66	disease	0.7	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.51	deleterious	-0.59	medium_impact	-1.48	low_impact	3.41	high_impact	0.23	0.9	NA	NA	0.65	P	0.90	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7224	7224	T	C	MI.4708	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1321	441	S	P	Tcg/Ccg	-2.19	0	0	probably_damaging	1	neutral	0.09	neutral	2.9	neutral	-1.43	neutral	-1.76	medium_impact	2.51	0.41	damaging	0.19	damaging	4.21	23.90	deleterious	0.34	0.55	0.2	neutral	0.43	neutral	0.17	neutral	0.4	neutral	2	1	deleterious	0.05	neutral	1	deleterious	0.69	deleterious	-3.58	low_impact	-0.37	medium_impact	1.22	medium_impact	0.61	0.9	NA	NA	0.55	P	0.91	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7224	7224	T	G	MI.4709	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1321	441	S	A	Tcg/Gcg	-2.19	0	0	probably_damaging	0.99	neutral	0.14	neutral	3.07	neutral	0.81	neutral	-1.01	medium_impact	2.02	0.6	neutral	0.2	damaging	3.90	23.50	deleterious	0.36	0.55	0.18	neutral	0.37	neutral	0.2	neutral	0.4	neutral	2	0.99	deleterious	0.08	neutral	1	deleterious	0.60	deleterious	-2.64	low_impact	-0.25	medium_impact	0.77	medium_impact	0.64	0.9	NA	NA	0.44	N	0.35	disease_causing	0.85	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8749	8749	T	A	MI.471	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	223	75	L	M	Tta/Ata	-10.75	0	0	probably_damaging	1	neutral	0.05	neutral	3.16	deleterious	-3.88	neutral	-1.79	medium_impact	2.81	0.65	neutral	0.54	neutral	3.52	23.10	deleterious	0.28	0.65	0.73	disease	0.53	disease	0.57	disease	0.52	disease	0	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.43	medium_impact	1.31	medium_impact	0.63	0.9	50.44	8.5	0.37	N	0.96	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7224	7224	T	A	MI.4710	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1321	441	S	T	Tcg/Acg	-2.19	0	0	probably_damaging	0.97	neutral	0.09	neutral	2.92	neutral	0.37	neutral	-0.97	medium_impact	2.88	0.52	damaging	0.15	damaging	4.09	23.70	deleterious	0.33	0.55	0.17	neutral	0.44	neutral	0.21	neutral	0.41	neutral	2	0.99	deleterious	0.06	neutral	1	deleterious	0.63	deleterious	-2.18	low_impact	-0.37	medium_impact	1.56	medium_impact	0.81	0.9	NA	NA	0.47	N	0.43	disease_causing	0.95	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7225	7225	C	G	MI.4711	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1322	441	S	W	tCg/tGg	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.85	neutral	-2.49	neutral	-2.48	high_impact	4.58	0.49	damaging	0.14	damaging	4.55	24.40	deleterious	0.23	0.55	0.78	disease	0.76	disease	0.59	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.49	0.9	NA	NA	0.54	P	0.94	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7225	7225	C	T	MI.4712	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1322	441	S	L	tCg/tTg	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	2.95	neutral	2.36	neutral	-2.1	high_impact	3.68	0.49	damaging	0.11	damaging	4.82	24.80	deleterious	0.28	0.55	0.29	neutral	0.7	disease	0.39	neutral	0.52	disease	0	1	deleterious	0.09	neutral	2	deleterious	0.69	deleterious	-3.58	low_impact	-0.17	medium_impact	2.3	high_impact	0.76	0.9	NA	NA	0.6	P	0.90	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7227	7227	G	A	MI.4713	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1324	442	D	N	Gac/Aac	-15.6	0	0	probably_damaging	1	deleterious	0.01	neutral	2.63	neutral	0.29	neutral	-1.68	high_impact	4.17	0.43	damaging	0.37	neutral	4.38	24.10	deleterious	0.73	0.75	0.68	disease	0.73	disease	0.53	disease	0.56	disease	1	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-0.92	medium_impact	2.75	high_impact	0.74	0.9	NA	NA	0.54	P	0.89	polymorphism	0.94	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7227	7227	G	C	MI.4714	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1324	442	D	H	Gac/Cac	-15.6	0	0	probably_damaging	1	deleterious	0.02	neutral	2.63	neutral	-0.5	neutral	-2.4	high_impact	4.07	0.5	damaging	0.29	neutral	3.85	23.40	deleterious	0.44	0.55	0.85	disease	0.72	disease	0.61	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.75	medium_impact	2.66	high_impact	0.58	0.9	NA	NA	0.32	N	0.97	polymorphism	0.75	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7227	7227	G	T	MI.4715	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1324	442	D	Y	Gac/Tac	-15.6	0	0	probably_damaging	1	deleterious	0	neutral	2.59	neutral	0.36	deleterious	-3.1	high_impact	4.97	0.38	damaging	0.29	neutral	4.09	23.70	deleterious	0.3	0.55	0.91	disease	0.85	disease	0.67	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.49	high_impact	0.32	0.9	NA	NA	0.65	P	0.94	polymorphism	0.58	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7228	7228	A	G	MI.4716	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1325	442	D	G	gAc/gGc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	0.47	neutral	-2.4	high_impact	4.97	0.45	damaging	0.43	neutral	4.24	23.90	deleterious	0.44	0.55	0.77	disease	0.75	disease	0.65	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.49	high_impact	0.43	0.9	NA	NA	0.73	P	0.85	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7228	7228	A	C	MI.4717	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1325	442	D	A	gAc/gCc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.72	neutral	2.15	deleterious	-2.76	high_impact	4.97	0.58	damaging	0.43	neutral	3.91	23.50	deleterious	0.42	0.55	0.74	disease	0.74	disease	0.66	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.49	high_impact	0.67	0.9	NA	NA	0.72	P	0.85	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7228	7228	A	T	MI.4718	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1325	442	D	V	gAc/gTc	6.14	1	0	probably_damaging	1	neutral	0.06	neutral	2.62	neutral	4.11	deleterious	-3.11	high_impact	4.28	0.45	damaging	0.34	neutral	4.04	23.70	deleterious	0.33	0.55	0.88	disease	0.84	disease	0.66	disease	0.78	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.86	deleterious	-3.58	low_impact	-0.47	medium_impact	2.85	high_impact	0.33	0.9	NA	NA	0.63	P	0.93	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7229	7229	C	G	MI.4719	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1326	442	D	E	gaC/gaG	5.6	1	0	probably_damaging	1	deleterious	0.01	neutral	2.73	neutral	0.61	neutral	-1.38	high_impact	3.93	0.44	damaging	0.35	neutral	4.11	23.80	deleterious	0.61	0.65	0.46	neutral	0.65	disease	0.48	neutral	0.51	disease	0	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-0.92	medium_impact	2.53	high_impact	0.61	0.9	NA	NA	0.7	P	0.65	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8749	8749	T	G	MI.472	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	223	75	L	V	Tta/Gta	-10.75	0	0	probably_damaging	0.99	neutral	0.06	neutral	3.29	neutral	-2.36	deleterious	-2.69	medium_impact	2.15	0.54	damaging	0.48	neutral	3.29	22.80	deleterious	0.28	0.65	0.6	disease	0.54	disease	0.48	neutral	0.47	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-2.65	low_impact	-0.38	medium_impact	0.75	medium_impact	0.54	0.9	50.44	8.5	0.4	N	0.87	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7229	7229	C	A	MI.4720	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1326	442	D	E	gaC/gaA	5.6	1	0	probably_damaging	1	deleterious	0.01	neutral	2.73	neutral	0.61	neutral	-1.38	high_impact	3.93	0.44	damaging	0.35	neutral	4.34	24.10	deleterious	0.61	0.65	0.46	neutral	0.65	disease	0.48	neutral	0.51	disease	0	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-0.92	medium_impact	2.53	high_impact	0.61	0.9	NA	NA	0.71	P	0.65	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7230	7230	T	C	MI.4721	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1327	443	Y	H	Tac/Cac	-0.86	0.02	0	probably_damaging	1	deleterious	0	neutral	2.39	deleterious	-3.86	neutral	-1.72	high_impact	4.24	0.62	neutral	0.05	damaging	3.82	23.40	deleterious	0.42	0.55	0.79	disease	0.72	disease	0.61	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.82	high_impact	0.22	0.9	2.92	6.71	0.34	N	0.61	disease_causing	0.87	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7230	7230	T	G	MI.4722	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1327	443	Y	D	Tac/Gac	-0.86	0.02	0	probably_damaging	1	deleterious	0	neutral	2.39	deleterious	-4.63	deleterious	-3.36	high_impact	4.93	0.52	damaging	0.05	damaging	4.18	23.80	deleterious	0.17	0.55	0.76	disease	0.83	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.23	0.9	2.92	6.71	0.62	P	0.98	disease_causing	0.98	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7230	7230	T	A	MI.4723	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1327	443	Y	N	Tac/Aac	-0.86	0.02	0	probably_damaging	1	deleterious	0	neutral	2.4	deleterious	-4.49	deleterious	-3.05	high_impact	4.58	0.53	damaging	0.06	damaging	4.42	24.20	deleterious	0.27	0.55	0.75	disease	0.84	disease	0.61	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.13	high_impact	0.19	0.9	2.92	6.71	0.4	N	0.94	disease_causing	0.99	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7231	7231	A	C	MI.4724	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1328	443	Y	S	tAc/tCc	4.67	1	0	probably_damaging	1	deleterious	0	neutral	2.42	deleterious	-3.95	deleterious	-3.01	high_impact	4.93	0.58	damaging	0.07	damaging	4.37	24.10	deleterious	0.28	0.55	0.49	neutral	0.82	disease	0.67	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.18	0.9	2.92	6.71	0.68	P	0.90	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7231	7231	A	G	MI.4725	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1328	443	Y	C	tAc/tGc	4.67	1	0	probably_damaging	1	deleterious	0	neutral	2.38	deleterious	-5.69	deleterious	-3.01	high_impact	4.93	0.55	damaging	0.05	damaging	4.25	23.90	deleterious	0.34	0.55	0.9	disease	0.83	disease	0.71	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.45	high_impact	0.16	0.9	2.92	6.71	0.64	P	0.89	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7231	7231	A	T	MI.4726	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1328	443	Y	F	tAc/tTc	4.67	1	0	probably_damaging	0.99	neutral	0.12	neutral	2.4	neutral	-0.47	neutral	-1.15	medium_impact	2.24	0.54	damaging	0.11	damaging	3.06	22.40	deleterious	0.3	0.55	0.46	neutral	0.6	disease	0.41	neutral	0.45	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-2.64	low_impact	-0.29	medium_impact	0.97	medium_impact	0.30	0.9	2.92	6.71	0.56	P	0.50	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7233	7233	C	T	MI.4727	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1330	444	P	S	Ccc/Tcc	-1.09	0	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.05	deleterious	-2.77	medium_impact	2.58	0.69	neutral	0.04	damaging	4.05	23.70	deleterious	0.34	0.55	0.36	neutral	0.75	disease	0.6	disease	0.63	disease	3	1	deleterious	0	neutral	5	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	1.28	medium_impact	0.28	0.9	NA	NA	0.24	N	0.85	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7233	7233	C	G	MI.4728	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1330	444	P	A	Ccc/Gcc	-1.09	0	0	probably_damaging	1	deleterious	0.03	neutral	2.77	neutral	-2.44	deleterious	-2.77	medium_impact	2.61	0.68	neutral	0.06	damaging	3.23	22.80	deleterious	0.32	0.55	0.37	neutral	0.61	disease	0.38	neutral	0.44	neutral	1	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-3.58	low_impact	-0.65	medium_impact	1.31	medium_impact	0.63	0.9	NA	NA	0.29	N	0.76	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7233	7233	C	A	MI.4729	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1330	444	P	T	Ccc/Acc	-1.09	0	0	probably_damaging	1	deleterious	0.01	neutral	2.72	neutral	-2.81	deleterious	-2.77	high_impact	3.52	0.7	neutral	0.04	damaging	4.01	23.60	deleterious	0.32	0.55	0.49	neutral	0.78	disease	0.6	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-0.92	medium_impact	2.15	high_impact	0.56	0.9	NA	NA	0.25	N	0.80	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8750	8750	T	C	MI.473	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	224	75	L	S	tTa/tCa	-1.49	0	0	probably_damaging	1	neutral	0.05	neutral	3.1	deleterious	-6.16	deleterious	-5.38	medium_impact	3.34	0.63	neutral	0.5	neutral	3.65	23.20	deleterious	0.19	0.65	0.86	disease	0.78	disease	0.63	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.43	medium_impact	1.77	medium_impact	0.60	0.9	50.44	8.5	0.31	N	0.98	polymorphism	0.78	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7234	7234	C	A	MI.4730	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1331	444	P	H	cCc/cAc	7.21	1	0	probably_damaging	1	deleterious	0.03	neutral	2.69	deleterious	-4.59	deleterious	-3.12	high_impact	3.9	0.69	neutral	0.02	damaging	4.21	23.90	deleterious	0.32	0.55	0.65	disease	0.76	disease	0.6	disease	0.64	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-0.65	medium_impact	2.5	high_impact	0.49	0.9	NA	NA	0.44	N	0.81	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7234	7234	C	G	MI.4731	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1331	444	P	R	cCc/cGc	7.21	1	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-3.94	deleterious	-3.12	high_impact	4.8	0.67	neutral	0.03	damaging	3.82	23.40	deleterious	0.31	0.55	0.49	neutral	0.84	disease	0.7	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.33	high_impact	0.43	0.9	NA	NA	0.68	P	0.90	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7234	7234	C	T	MI.4732	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1331	444	P	L	cCc/cTc	7.21	1	0	probably_damaging	1	deleterious	0.03	neutral	2.8	neutral	-1.84	deleterious	-3.47	medium_impact	3.36	0.69	neutral	0.02	damaging	4.61	24.40	deleterious	0.35	0.55	0.32	neutral	0.83	disease	0.6	disease	0.67	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.65	medium_impact	2	high_impact	0.65	0.9	NA	NA	0.46	N	0.87	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7236	7236	G	A	MI.4733	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1333	445	D	N	Gat/Aat	-0.86	0.02	0	benign	0.04	deleterious	0.01	neutral	2.74	neutral	-2.99	neutral	-1.6	high_impact	4.03	0.52	damaging	0.06	damaging	4.38	24.10	deleterious	0.51	0.6	0.42	neutral	0.74	disease	0.49	neutral	0.52	disease	0	0.99	deleterious	0.49	deleterious	2	deleterious	0.24	neutral	0.54	medium_impact	-0.92	medium_impact	2.62	high_impact	0.58	0.9	4.48	7.17	0.37	N	0.89	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7236	7236	G	C	MI.4734	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1333	445	D	H	Gat/Cat	-0.86	0.02	0	probably_damaging	0.94	deleterious	0	neutral	2.72	deleterious	-4.17	neutral	-2.34	high_impact	4.92	0.57	damaging	0.04	damaging	3.92	23.50	deleterious	0.33	0.55	0.58	disease	0.75	disease	0.66	disease	0.69	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.77	deleterious	-1.88	low_impact	-1.48	low_impact	3.44	high_impact	0.39	0.9	4.48	7.17	0.58	P	0.97	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7236	7236	G	T	MI.4735	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1333	445	D	Y	Gat/Tat	-0.86	0.02	0	probably_damaging	0.99	deleterious	0	neutral	2.75	deleterious	-4.28	deleterious	-3.05	high_impact	4.58	0.55	damaging	0.04	damaging	4.17	23.80	deleterious	0.27	0.55	0.67	disease	0.86	disease	0.65	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	3.13	high_impact	0.26	0.9	4.48	7.17	0.4	N	0.94	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7237	7237	A	C	MI.4736	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1334	445	D	A	gAt/gCt	9.29	1	0	possibly_damaging	0.57	neutral	0.06	neutral	2.8	neutral	-2.46	deleterious	-2.71	high_impact	3.95	0.63	neutral	0.07	damaging	4.02	23.60	deleterious	0.29	0.55	0.36	neutral	0.75	disease	0.62	disease	0.68	disease	4	0.94	neutral	0.25	neutral	1	deleterious	0.57	deleterious	-0.87	medium_impact	-0.47	medium_impact	2.55	high_impact	0.36	0.9	4.48	7.17	0.53	P	0.85	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7237	7237	A	G	MI.4737	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1334	445	D	G	gAt/gGt	9.29	1	0	possibly_damaging	0.65	deleterious	0	neutral	2.75	neutral	-1.03	neutral	-2.35	high_impact	4.58	0.58	damaging	0.05	damaging	4.29	24.00	deleterious	0.33	0.55	0.53	disease	0.79	disease	0.62	disease	0.7	disease	4	1	deleterious	0.18	neutral	5	deleterious	0.50	deleterious	-1.01	low_impact	-1.48	low_impact	3.13	high_impact	0.28	0.9	4.48	7.17	0.49	P	0.85	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7237	7237	A	T	MI.4738	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1334	445	D	V	gAt/gTt	9.29	1	0	probably_damaging	0.92	deleterious	0	neutral	2.78	neutral	-2.85	deleterious	-3.06	high_impact	4.38	0.56	damaging	0.05	damaging	4.09	23.70	deleterious	0.33	0.55	0.4	neutral	0.85	disease	0.62	disease	0.73	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.73	deleterious	-1.76	low_impact	-1.48	low_impact	2.95	high_impact	0.20	0.9	4.48	7.17	0.42	N	0.93	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7238	7238	T	G	MI.4739	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1335	445	D	E	gaT/gaG	6.98	1	0	benign	0.22	deleterious	0.03	neutral	2.78	neutral	-2.27	neutral	-1.34	medium_impact	3.38	0.49	damaging	0.05	damaging	4.08	23.70	deleterious	0.4	0.55	0.24	neutral	0.65	disease	0.3	neutral	0.44	neutral	1	0.97	neutral	0.41	neutral	1	deleterious	0.27	neutral	-0.24	medium_impact	-0.65	medium_impact	2.02	high_impact	0.38	0.9	4.48	7.17	0.53	P	0.65	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8750	8750	T	G	MI.474	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	224	75	L	W	tTa/tGa	-1.49	0	0	probably_damaging	1	deleterious	0	neutral	3.09	deleterious	-7.41	deleterious	-5.46	high_impact	4.38	0.55	damaging	0.4	neutral	3.64	23.20	deleterious	0.11	0.65	0.96	disease	0.79	disease	0.68	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	2.66	high_impact	0.48	0.9	50.44	8.5	0.36	N	1.00	polymorphism	0.69	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7238	7238	T	A	MI.4740	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1335	445	D	E	gaT/gaA	6.98	1	0	benign	0.22	deleterious	0.03	neutral	2.78	neutral	-2.27	neutral	-1.34	medium_impact	3.38	0.49	damaging	0.05	damaging	4.22	23.90	deleterious	0.4	0.55	0.24	neutral	0.65	disease	0.3	neutral	0.44	neutral	1	0.97	neutral	0.41	neutral	1	deleterious	0.27	neutral	-0.24	medium_impact	-0.65	medium_impact	2.02	high_impact	0.38	0.9	4.48	7.17	0.53	P	0.65	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7239	7239	G	C	MI.4741	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1336	446	A	P	Gca/Cca	-4.09	0	0	probably_damaging	1	deleterious	0.01	neutral	2.71	neutral	-1.9	neutral	-1.31	high_impact	3.62	0.45	damaging	0.06	damaging	4.03	23.60	deleterious	0.14	0.55	0.7	disease	0.74	disease	0.65	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-0.92	medium_impact	2.24	high_impact	0.80	0.9	NA	NA	0.32	N	0.85	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7239	7239	G	A	MI.4742	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1336	446	A	T	Gca/Aca	-4.09	0	0	probably_damaging	1	neutral	0.16	neutral	2.75	neutral	-0.39	neutral	-0.81	medium_impact	1.96	0.51	damaging	0.06	damaging	3.31	22.90	deleterious	0.43	0.55	0.49	neutral	0.49	neutral	0.23	neutral	0.47	neutral	1	1	deleterious	0.08	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.21	medium_impact	0.71	medium_impact	0.64	0.9	NA	NA	0.36	N	0.20	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7239	7239	G	T	MI.4743	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1336	446	A	S	Gca/Tca	-4.09	0	0	probably_damaging	1	neutral	0.24	neutral	2.77	neutral	-0.51	neutral	-0.43	neutral_impact	0.6	0.52	damaging	0.08	damaging	2.44	19.08	deleterious	0.39	0.55	0.44	neutral	0.19	neutral	0.18	neutral	0.36	neutral	3	1	deleterious	0.12	neutral	-2	neutral	0.72	deleterious	-3.58	low_impact	-0.09	medium_impact	-0.55	medium_impact	0.77	0.9	NA	NA	0.46	N	0.64	disease_causing	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7240	7240	C	T	MI.4744	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1337	446	A	V	gCa/gTa	6.06	1	0	probably_damaging	1	neutral	0.16	neutral	2.78	neutral	1	neutral	-1.04	medium_impact	2.19	0.5	damaging	0.08	damaging	3.45	23.00	deleterious	0.29	0.55	0.41	neutral	0.47	neutral	0.24	neutral	0.48	neutral	0	1	deleterious	0.08	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.21	medium_impact	0.92	medium_impact	0.65	0.9	NA	NA	0.61	P	0.75	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7240	7240	C	A	MI.4745	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1337	446	A	E	gCa/gAa	6.06	1	0	probably_damaging	1	neutral	0.06	neutral	2.79	neutral	-1.22	neutral	-1.2	medium_impact	2.58	0.5	damaging	0.07	damaging	4.63	24.50	deleterious	0.15	0.55	0.26	neutral	0.7	disease	0.63	disease	0.69	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.74	deleterious	-3.58	low_impact	-0.47	medium_impact	1.28	medium_impact	0.58	0.9	NA	NA	0.52	P	0.76	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7240	7240	C	G	MI.4746	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1337	446	A	G	gCa/gGa	6.06	1	0	probably_damaging	0.99	neutral	0.08	neutral	2.75	neutral	-1.4	neutral	-1	low_impact	1.52	0.53	damaging	0.09	damaging	4.12	23.80	deleterious	0.3	0.55	0.29	neutral	0.47	neutral	0.37	neutral	0.47	neutral	1	1	deleterious	0.05	neutral	-2	neutral	0.69	deleterious	-2.64	low_impact	-0.4	medium_impact	0.3	medium_impact	0.73	0.9	NA	NA	0.55	P	0.56	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7242	7242	T	C	MI.4747	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1339	447	Y	H	Tac/Cac	-5.47	0	0	probably_damaging	1	deleterious	0	neutral	2.71	neutral	-0.95	neutral	-1.56	high_impact	3.95	0.61	neutral	0.05	damaging	3.78	23.40	deleterious	0.34	0.55	0.69	disease	0.71	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.55	high_impact	0.43	0.9	1.75	6.73	0.3	N	0.61	polymorphism	0.92	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7242	7242	T	A	MI.4748	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1339	447	Y	N	Tac/Aac	-5.47	0	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-0.48	deleterious	-2.6	high_impact	3.95	0.55	damaging	0.06	damaging	4.23	23.90	deleterious	0.28	0.55	0.77	disease	0.84	disease	0.67	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.55	high_impact	0.20	0.9	1.75	6.73	0.24	N	0.94	polymorphism	0.52	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7242	7242	T	G	MI.4749	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1339	447	Y	D	Tac/Gac	-5.47	0	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-0.91	deleterious	-2.8	high_impact	4.29	0.52	damaging	0.05	damaging	4.20	23.90	deleterious	0.19	0.55	0.85	disease	0.85	disease	0.74	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.86	high_impact	0.36	0.9	1.75	6.73	0.33	N	0.98	polymorphism	0.6	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8751	8751	A	T	MI.475	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	225	75	L	F	ttA/ttT	5.68	0.9	0	probably_damaging	1	deleterious	0.01	neutral	3.16	deleterious	-3.94	deleterious	-3.61	medium_impact	3.23	0.55	damaging	0.4	neutral	3.50	23.10	deleterious	0.3	0.65	0.84	disease	0.72	disease	0.65	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	1.67	medium_impact	0.58	0.9	50.44	8.5	0.48	N	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7243	7243	A	T	MI.4750	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1340	447	Y	F	tAc/tTc	5.83	1	0	probably_damaging	1	neutral	0.25	neutral	2.86	neutral	1.2	neutral	-0.26	neutral_impact	0.11	0.51	damaging	0.15	damaging	1.91	15.63	deleterious	0.4	0.55	0.17	neutral	0.17	neutral	0.24	neutral	0.25	neutral	5	1	deleterious	0.13	neutral	-2	neutral	0.69	deleterious	-3.58	low_impact	-0.07	medium_impact	-1	medium_impact	0.45	0.9	1.75	6.73	0.64	P	0.50	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7243	7243	A	C	MI.4751	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1340	447	Y	S	tAc/tCc	5.83	1	0	probably_damaging	1	deleterious	0	neutral	2.73	neutral	0.68	neutral	-2.44	high_impact	3.95	0.59	damaging	0.07	damaging	3.85	23.40	deleterious	0.27	0.55	0.69	disease	0.82	disease	0.66	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.55	high_impact	0.25	0.9	1.75	6.73	0.44	N	0.90	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7243	7243	A	G	MI.4752	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1340	447	Y	C	tAc/tGc	5.83	1	0	probably_damaging	1	deleterious	0	neutral	2.7	neutral	-0.97	neutral	-2.44	high_impact	4.29	0.55	damaging	0.05	damaging	3.63	23.20	deleterious	0.32	0.55	0.85	disease	0.85	disease	0.69	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.86	high_impact	0.15	0.9	1.75	6.73	0.45	N	0.89	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7245	7245	A	G	MI.4753	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1342	448	T	A	Acc/Gcc	-3.86	0	0	probably_damaging	0.97	neutral	0.35	neutral	2.85	neutral	0.28	neutral	-0.82	low_impact	1.43	0.68	neutral	0.65	neutral	2.33	18.34	deleterious	0.62	0.65	0.28	neutral	0.15	neutral	0.16	neutral	0.28	neutral	4	0.97	neutral	0.19	neutral	-2	neutral	0.64	deleterious	-2.18	low_impact	0.04	medium_impact	0.22	medium_impact	0.48	0.9	2.34	7.44	0.51	N	0.69	polymorphism	0.52	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7245	7245	A	T	MI.4754	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1342	448	T	S	Acc/Tcc	-3.86	0	0	probably_damaging	0.97	neutral	0.53	neutral	2.8	neutral	-0.32	neutral	-0.74	low_impact	1	0.65	neutral	0.68	neutral	2.07	16.68	deleterious	0.45	0.55	0.36	neutral	0.28	neutral	0.16	neutral	0.46	neutral	1	0.97	neutral	0.28	neutral	-2	neutral	0.68	deleterious	-2.18	low_impact	0.22	medium_impact	-0.18	medium_impact	0.71	0.9	2.34	7.44	0.43	N	0.79	polymorphism	0.76	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7245	7245	A	C	MI.4755	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1342	448	T	P	Acc/Ccc	-3.86	0	0	probably_damaging	1	deleterious	0.03	neutral	2.71	neutral	-2.02	neutral	-1.35	high_impact	3.86	0.56	damaging	0.42	neutral	3.60	23.20	deleterious	0.17	0.55	0.66	disease	0.7	disease	0.48	neutral	0.51	disease	0	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.65	medium_impact	2.47	high_impact	0.66	0.9	2.34	7.44	0.39	N	0.92	disease_causing	0.82	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7246	7246	C	G	MI.4756	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1343	448	T	S	aCc/aGc	3.75	0.98	0	probably_damaging	0.97	neutral	0.53	neutral	2.8	neutral	-0.32	neutral	-0.74	low_impact	1	0.65	neutral	0.68	neutral	2.37	18.65	deleterious	0.45	0.55	0.36	neutral	0.28	neutral	0.16	neutral	0.46	neutral	1	0.97	neutral	0.28	neutral	-2	neutral	0.68	deleterious	-2.18	low_impact	0.22	medium_impact	-0.18	medium_impact	0.71	0.9	2.34	7.44	0.49	P	0.79	disease_causing	0.91	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7246	7246	C	T	MI.4757	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1343	448	T	I	aCc/aTc	3.75	0.98	0	probably_damaging	1	neutral	0.08	neutral	2.75	neutral	3.5	neutral	-0.79	low_impact	1.68	0.61	neutral	0.62	neutral	3.08	22.50	deleterious	0.42	0.55	0.47	neutral	0.41	neutral	0.2	neutral	0.47	neutral	1	1	deleterious	0.04	neutral	-2	neutral	0.73	deleterious	-3.58	low_impact	-0.4	medium_impact	0.45	medium_impact	0.70	0.9	2.34	7.44	0.6	P	0.92	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7246	7246	C	A	MI.4758	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1343	448	T	N	aCc/aAc	3.75	0.98	0	probably_damaging	1	deleterious	0.04	neutral	2.77	neutral	-1.52	neutral	-1.14	medium_impact	2.88	0.63	neutral	0.53	neutral	3.85	23.40	deleterious	0.53	0.6	0.43	neutral	0.6	disease	0.31	neutral	0.53	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-3.58	low_impact	-0.58	medium_impact	1.56	medium_impact	0.77	0.9	2.34	7.44	0.54	P	0.80	disease_causing	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7248	7248	A	T	MI.4759	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1345	449	T	S	Aca/Tca	-6.63	0	0	benign	0.18	neutral	0.34	neutral	2.77	neutral	2.51	neutral	-0.02	neutral_impact	-0.08	0.7	neutral	0.74	neutral	-0.37	0.46	neutral	0.4	0.55	0.32	neutral	0.08	neutral	0.17	neutral	0.29	neutral	4	0.6	neutral	0.58	deleterious	-6	neutral	0.19	neutral	-0.14	medium_impact	0.03	medium_impact	-1.17	low_impact	0.72	0.9	7.99	16.77	0.58	P	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8751	8751	A	C	MI.476	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	225	75	L	F	ttA/ttC	5.68	0.9	0	probably_damaging	1	deleterious	0.01	neutral	3.16	deleterious	-3.94	deleterious	-3.61	medium_impact	3.23	0.55	damaging	0.4	neutral	3.36	22.90	deleterious	0.3	0.65	0.84	disease	0.72	disease	0.65	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	1.67	medium_impact	0.58	0.9	50.44	8.5	0.47	N	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7248	7248	A	C	MI.4760	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1345	449	T	P	Aca/Cca	-6.63	0	0	possibly_damaging	0.54	neutral	0.08	neutral	3	neutral	-2.15	neutral	-0.82	low_impact	1.64	0.55	damaging	0.4	neutral	0.68	8.71	deleterious	0.18	0.55	0.61	disease	0.54	disease	0.49	neutral	0.49	neutral	0	0.92	neutral	0.27	neutral	-3	neutral	0.47	deleterious	-0.82	medium_impact	-0.4	medium_impact	0.42	medium_impact	0.70	0.9	7.99	16.77	0.4	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7248	7248	A	G	MI.4761	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1345	449	T	A	Aca/Gca	-6.63	0	0	benign	0.01	neutral	0.23	neutral	2.83	neutral	0.2	neutral	-0.26	low_impact	1.5	0.76	neutral	0.96	neutral	-0.22	0.99	neutral	0.5	0.55	0.16	neutral	0.15	neutral	0.31	neutral	0.28	neutral	4	0.76	neutral	0.61	deleterious	-6	neutral	0.09	neutral	1.12	medium_impact	-0.1	medium_impact	0.29	medium_impact	0.50	0.9	7.99	16.77	0.47	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7249	7249	C	A	MI.4762	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1346	449	T	K	aCa/aAa	-0.17	0	0	benign	0.26	neutral	0.25	neutral	2.75	neutral	1.76	neutral	-0.43	medium_impact	1.96	0.66	neutral	0.63	neutral	1.16	11.52	neutral	0.26	0.55	0.41	neutral	0.24	neutral	0.47	neutral	0.43	neutral	1	0.7	neutral	0.5	deleterious	-3	neutral	0.34	neutral	-0.33	medium_impact	-0.07	medium_impact	0.71	medium_impact	0.65	0.9	7.99	16.77	0.47	N	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7249	7249	C	T	MI.4763	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1346	449	T	M	aCa/aTa	-0.17	0	0	benign	0.05	neutral	0.25	neutral	2.77	neutral	-1.3	neutral	-0.16	neutral_impact	0.78	0.76	neutral	0.97	neutral	0.80	9.49	deleterious	0.34	0.55	0.37	neutral	0.13	neutral	0.22	neutral	0.31	neutral	4	0.73	neutral	0.6	deleterious	-6	neutral	0.13	neutral	0.45	medium_impact	-0.07	medium_impact	-0.38	medium_impact	0.66	0.9	7.99	16.77	0.52	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7251	7251	T	C	MI.4764	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1348	450	W	R	Tga/Cga	-2.71	0	0	probably_damaging	1	deleterious	0	neutral	2.64	deleterious	-5.28	deleterious	-4.84	high_impact	4.86	0.49	damaging	0.19	damaging	3.73	23.30	deleterious	0.22	0.55	0.63	disease	0.88	disease	0.85	disease	0.86	disease	7	1	deleterious	0	deleterious	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.40	0.9	3.12	6.92	0.66	P	0.98	polymorphism	0.99	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7251	7251	T	G	MI.4765	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1348	450	W	G	Tga/Gga	-2.71	0	0	probably_damaging	1	deleterious	0	neutral	2.65	deleterious	-4.67	deleterious	-4.49	high_impact	4.86	0.57	damaging	0.35	neutral	4.12	23.80	deleterious	0.19	0.55	0.48	neutral	0.83	disease	0.82	disease	0.82	disease	6	1	deleterious	0	deleterious	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.32	0.9	3.12	6.92	0.66	P	0.89	polymorphism	0.98	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7252	7252	G	C	MI.4766	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1349	450	W	S	tGa/tCa	5.83	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-4.98	deleterious	-4.84	high_impact	4.51	0.65	neutral	0.33	neutral	4.20	23.90	deleterious	0.17	0.55	0.52	disease	0.9	disease	0.8	disease	0.82	disease	6	1	deleterious	0	deleterious	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.07	high_impact	0.30	0.9	3.12	6.92	0.51	P	0.89	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7252	7252	G	T	MI.4767	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1349	450	W	L	tGa/tTa	5.83	1	0	probably_damaging	1	deleterious	0	neutral	2.83	deleterious	-4.37	deleterious	-4.5	medium_impact	2.73	0.58	damaging	0.32	neutral	4.41	24.10	deleterious	0.21	0.55	0.16	neutral	0.83	disease	0.78	disease	0.78	disease	6	1	deleterious	0	deleterious	5	deleterious	0.74	deleterious	-3.58	low_impact	-1.48	low_impact	1.42	medium_impact	0.36	0.9	3.12	6.92	0.43	N	0.95	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7253	7253	A	C	MI.4768	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1350	450	W	C	tgA/tgC	9.29	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-6.86	deleterious	-4.5	high_impact	4.86	0.56	damaging	0.2	damaging	4.19	23.80	deleterious	0.21	0.55	0.73	disease	0.89	disease	0.83	disease	0.85	disease	7	1	deleterious	0	deleterious	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.28	0.9	3.12	6.92	0.68	P	0.88	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7253	7253	A	T	MI.4769	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1350	450	W	C	tgA/tgT	9.29	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-6.86	deleterious	-4.5	high_impact	4.86	0.56	damaging	0.2	damaging	4.32	24.00	deleterious	0.21	0.55	0.73	disease	0.89	disease	0.83	disease	0.85	disease	7	1	deleterious	0	deleterious	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.28	0.9	3.12	6.92	0.69	P	0.88	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8752	8752	A	C	MI.477	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	226	76	I	L	Atc/Ctc	-1.95	0	0	probably_damaging	0.93	neutral	0.19	neutral	4.66	neutral	1.66	neutral	-0.53	neutral_impact	-0.16	0.92	neutral	0.81	neutral	2.47	19.24	deleterious	0.22	0.65	0.36	neutral	0.41	neutral	0.25	neutral	0.45	neutral	1	0.96	neutral	0.13	neutral	-2	neutral	0.62	deleterious	-1.82	low_impact	-0.06	medium_impact	-1.24	low_impact	0.47	0.9	18.58	16.92	0.43	N	0.83	polymorphism	0.5	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7254	7254	A	C	MI.4770	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1351	451	N	H	Aac/Cac	8.59	1	0	probably_damaging	1	deleterious	0.03	neutral	2.77	deleterious	-4.61	neutral	-1.73	medium_impact	2.66	0.54	damaging	0.06	damaging	3.29	22.80	deleterious	0.35	0.55	0.43	neutral	0.72	disease	0.64	disease	0.52	disease	0	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.58	low_impact	-0.65	medium_impact	1.36	medium_impact	0.68	0.9	2.34	6.89	0.42	N	0.83	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7254	7254	A	T	MI.4771	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1351	451	N	Y	Aac/Tac	8.59	1	0	probably_damaging	1	deleterious	0	neutral	2.87	deleterious	-5.08	deleterious	-2.76	high_impact	4.62	0.53	damaging	0.05	damaging	3.93	23.50	deleterious	0.21	0.55	0.83	disease	0.85	disease	0.76	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.64	0.9	2.34	6.89	0.55	P	0.93	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7254	7254	A	G	MI.4772	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1351	451	N	D	Aac/Gac	8.59	1	0	probably_damaging	0.99	deleterious	0	neutral	2.76	neutral	-2.69	neutral	-1.73	high_impact	4.96	0.44	damaging	0.06	damaging	4.05	23.70	deleterious	0.49	0.55	0.57	disease	0.73	disease	0.81	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.79	deleterious	-2.64	low_impact	-1.48	low_impact	3.48	high_impact	0.79	0.9	2.34	6.89	0.78	P	0.92	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7255	7255	A	G	MI.4773	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1352	451	N	S	aAc/aGc	8.59	1	0	probably_damaging	0.98	neutral	0.07	neutral	2.76	deleterious	-3.03	neutral	-1.72	high_impact	4.16	0.54	damaging	0.07	damaging	3.15	22.60	deleterious	0.5	0.6	0.55	disease	0.77	disease	0.74	disease	0.76	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.82	deleterious	-2.35	low_impact	-0.43	medium_impact	2.74	high_impact	0.54	0.9	2.34	6.89	0.56	P	0.79	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7255	7255	A	T	MI.4774	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1352	451	N	I	aAc/aTc	8.59	1	0	probably_damaging	1	deleterious	0	neutral	2.79	deleterious	-4.69	deleterious	-3.11	high_impact	4.96	0.57	damaging	0.06	damaging	3.96	23.60	deleterious	0.21	0.55	0.79	disease	0.88	disease	0.74	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.48	high_impact	0.57	0.9	2.34	6.89	0.73	P	0.98	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7255	7255	A	C	MI.4775	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1352	451	N	T	aAc/aCc	8.59	1	0	probably_damaging	1	deleterious	0	neutral	2.77	deleterious	-3.52	neutral	-2.07	high_impact	4.62	0.57	damaging	0.07	damaging	3.51	23.10	deleterious	0.35	0.55	0.61	disease	0.79	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.17	high_impact	0.75	0.9	2.34	6.89	0.56	P	0.59	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7256	7256	C	A	MI.4776	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1353	451	N	K	aaC/aaA	8.59	1	0.01	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-2.7	neutral	-2.07	high_impact	4.26	0.51	damaging	0.04	damaging	4.63	24.50	deleterious	0.42	0.55	0.28	neutral	0.77	disease	0.81	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.73	0.9	2.34	6.89	0.56	P	0.92	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7256	7256	C	G	MI.4777	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1353	451	N	K	aaC/aaG	8.59	1	0.01	probably_damaging	1	deleterious	0	neutral	2.76	neutral	-2.7	neutral	-2.07	high_impact	4.26	0.51	damaging	0.04	damaging	4.13	23.80	deleterious	0.42	0.55	0.28	neutral	0.77	disease	0.81	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.58	low_impact	-1.48	low_impact	2.83	high_impact	0.73	0.9	2.34	6.89	0.56	P	0.92	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7257	7257	A	T	MI.4778	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1354	452	I	F	Atc/Ttc	-6.63	0	0	benign	0.22	neutral	0.12	neutral	2.73	neutral	-1.33	neutral	-1.02	low_impact	1.09	0.66	neutral	0.68	neutral	2.25	17.81	deleterious	0.47	0.55	0.22	neutral	0.54	disease	0.21	neutral	0.42	neutral	2	0.86	neutral	0.45	neutral	-6	neutral	0.23	neutral	-0.24	medium_impact	-0.29	medium_impact	-0.09	medium_impact	0.83	0.9	15.2	52.77	0.52	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7257	7257	A	G	MI.4779	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1354	452	I	V	Atc/Gtc	-6.63	0	0	benign	0	neutral	0.81	neutral	2.82	neutral	-0.11	neutral	-0.02	neutral_impact	-0.22	0.8	neutral	0.99	neutral	-1.29	0.01	neutral	0.6	0.65	0.16	neutral	0.09	neutral	0.18	neutral	0.27	neutral	5	0.18	neutral	0.91	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.54	medium_impact	-1.3	low_impact	0.72	0.9	15.2	52.77	0.41	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8752	8752	A	T	MI.478	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	226	76	I	F	Atc/Ttc	-1.95	0	0	probably_damaging	0.99	neutral	1	neutral	5.08	neutral	2.92	neutral	-2.17	neutral_impact	-1.18	0.92	neutral	0.9	neutral	2.50	19.44	deleterious	0.23	0.65	0.51	disease	0.33	neutral	0.36	neutral	0.34	neutral	3	0.99	deleterious	0.51	deleterious	-2	neutral	0.68	deleterious	-2.65	low_impact	1.98	high_impact	-2.11	low_impact	0.60	0.9	18.58	16.92	0.27	N	0.97	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7257	7257	A	C	MI.4780	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1354	452	I	L	Atc/Ctc	-6.63	0	0	benign	0.01	neutral	0.39	neutral	2.91	neutral	-0.17	neutral	-0.38	neutral_impact	0.3	0.71	neutral	0.8	neutral	0.38	6.41	deleterious	0.37	0.55	0.17	neutral	0.26	neutral	0.16	neutral	0.43	neutral	1	0.6	neutral	0.69	deleterious	-6	neutral	0.08	neutral	1.12	medium_impact	0.09	medium_impact	-0.82	medium_impact	0.75	0.9	15.2	52.77	0.54	N	0.14	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7258	7258	T	A	MI.4781	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1355	452	I	N	aTc/aAc	0.75	0	0.01	benign	0.14	deleterious	0.02	neutral	2.68	neutral	2.81	neutral	-1.52	medium_impact	2.4	0.64	neutral	0.48	neutral	2.95	22.10	deleterious	0.32	0.55	0.47	neutral	0.66	disease	0.36	neutral	0.51	disease	0	0.98	neutral	0.44	neutral	1	deleterious	0.27	neutral	-0.01	medium_impact	-0.75	medium_impact	1.12	medium_impact	0.74	0.9	15.2	52.77	0.42	N	0.17	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7258	7258	T	C	MI.4782	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1355	452	I	T	aTc/aCc	0.75	0	0.01	benign	0	neutral	1	neutral	2.73	neutral	-0.01	neutral	-0.78	neutral_impact	0.46	0.75	neutral	0.97	neutral	-0.45	0.29	neutral	0.41	0.55	0.16	neutral	0.27	neutral	0.24	neutral	0.42	neutral	2	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	1.86	high_impact	-0.67	medium_impact	0.72	0.9	15.2	52.77	0.38	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7258	7258	T	G	MI.4783	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1355	452	I	S	aTc/aGc	0.75	0	0.01	benign	0	neutral	0.26	neutral	2.72	neutral	0.36	neutral	-1.23	neutral_impact	0.72	0.71	neutral	0.83	neutral	1.29	12.21	neutral	0.31	0.55	0.23	neutral	0.54	disease	0.26	neutral	0.43	neutral	1	0.74	neutral	0.63	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	-0.06	medium_impact	-0.43	medium_impact	0.69	0.9	15.2	52.77	0.47	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7259	7259	C	A	MI.4784	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1356	452	I	M	atC/atA	1.68	0	0	benign	0.02	neutral	0.19	neutral	2.75	neutral	-1.59	neutral	-0.44	neutral_impact	0.12	0.74	neutral	0.93	neutral	2.22	17.63	deleterious	0.54	0.6	0.25	neutral	0.13	neutral	0.18	neutral	0.29	neutral	4	0.8	neutral	0.59	deleterious	-6	neutral	0.09	neutral	0.83	medium_impact	-0.16	medium_impact	-0.99	medium_impact	0.84	0.9	15.2	52.77	0.6	P	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7259	7259	C	G	MI.4785	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1356	452	I	M	atC/atG	1.68	0	0	benign	0.02	neutral	0.19	neutral	2.75	neutral	-1.59	neutral	-0.44	neutral_impact	0.12	0.74	neutral	0.93	neutral	1.74	14.65	neutral	0.54	0.6	0.25	neutral	0.13	neutral	0.18	neutral	0.29	neutral	4	0.8	neutral	0.59	deleterious	-6	neutral	0.09	neutral	0.83	medium_impact	-0.16	medium_impact	-0.99	medium_impact	0.84	0.9	15.2	52.77	0.59	P	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7260	7260	C	A	MI.4786	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1357	453	L	M	Cta/Ata	-13.08	0	0	benign	0.02	neutral	0.12	neutral	2.59	neutral	-1.38	neutral	-0.23	neutral_impact	0.78	0.76	neutral	0.86	neutral	2.34	18.40	deleterious	0.34	0.55	0.4	neutral	0.25	neutral	0.29	neutral	0.46	neutral	1	0.88	neutral	0.55	deleterious	-6	neutral	0.12	neutral	0.83	medium_impact	-0.29	medium_impact	-0.38	medium_impact	0.73	0.9	14.23	34.92	0.48	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7260	7260	C	G	MI.4787	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1357	453	L	V	Cta/Gta	-13.08	0	0	benign	0	neutral	1	neutral	2.69	neutral	-0.29	neutral	0.35	neutral_impact	-0.7	0.84	neutral	0.99	neutral	-0.84	0.03	neutral	0.34	0.55	0.2	neutral	0.08	neutral	0.22	neutral	0.25	neutral	5	0	neutral	1	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	1.86	high_impact	-1.75	low_impact	0.72	0.9	14.23	34.92	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7261	7261	T	C	MI.4788	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1358	453	L	P	cTa/cCa	-2.48	0	0	benign	0.35	deleterious	0	neutral	2.5	neutral	0.34	neutral	-1.6	medium_impact	3.1	0.56	damaging	0.44	neutral	4.00	23.60	deleterious	0.09	0.55	0.81	disease	0.83	disease	0.64	disease	0.82	disease	6	1	deleterious	0.33	neutral	1	deleterious	0.58	deleterious	-0.5	medium_impact	-1.48	low_impact	1.76	medium_impact	0.57	0.9	14.23	34.92	0.29	N	0.73	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7261	7261	T	A	MI.4789	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1358	453	L	Q	cTa/cAa	-2.48	0	0	possibly_damaging	0.46	deleterious	0	neutral	2.5	neutral	-0.18	neutral	-1.54	medium_impact	3.1	0.68	neutral	0.6	neutral	4.20	23.90	deleterious	0.11	0.55	0.78	disease	0.59	disease	0.49	neutral	0.54	disease	1	1	deleterious	0.27	neutral	4	deleterious	0.46	deleterious	-0.69	medium_impact	-1.48	low_impact	1.76	medium_impact	0.66	0.9	14.23	34.92	0.37	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8752	8752	A	G	MI.479	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	226	76	I	V	Atc/Gtc	-1.95	0	0	probably_damaging	0.93	deleterious	0.02	neutral	4.32	neutral	-1.01	neutral	-0.48	low_impact	1.59	0.93	neutral	0.6	neutral	1.82	15.12	deleterious	0.36	0.65	0.49	neutral	0.28	neutral	0.34	neutral	0.4	neutral	2	0.99	deleterious	0.05	neutral	2	deleterious	0.63	deleterious	-1.82	low_impact	-0.66	medium_impact	0.27	medium_impact	0.32	0.9	18.58	16.92	0.47	N	0.77	polymorphism	0.7	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7261	7261	T	G	MI.4790	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1358	453	L	R	cTa/cGa	-2.48	0	0	benign	0.35	deleterious	0	neutral	2.5	neutral	-2.44	neutral	-1.64	medium_impact	3.1	0.63	neutral	0.5	neutral	4.28	24.00	deleterious	0.08	0.55	0.77	disease	0.81	disease	0.64	disease	0.79	disease	6	1	deleterious	0.33	neutral	1	deleterious	0.50	deleterious	-0.5	medium_impact	-1.48	low_impact	1.76	medium_impact	0.69	0.9	14.23	34.92	0.31	N	0.66	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7263	7263	T	A	MI.4791	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1360	454	S	T	Tca/Aca	-20	0	0	probably_damaging	0.97	deleterious	0	neutral	2.77	deleterious	-3.75	neutral	-1.03	high_impact	3.94	0.5	damaging	0.16	damaging	3.89	23.50	deleterious	0.22	0.55	0.5	disease	0.64	disease	0.66	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.18	low_impact	-1.48	low_impact	2.54	high_impact	0.73	0.9	1.56	6.65	0.4	N	0.43	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7263	7263	T	G	MI.4792	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1360	454	S	A	Tca/Gca	-20	0	0	probably_damaging	0.99	neutral	0.06	neutral	2.87	neutral	-2.98	neutral	-1.03	medium_impact	2.8	0.6	damaging	0.18	damaging	3.87	23.50	deleterious	0.28	0.55	0.28	neutral	0.46	neutral	0.47	neutral	0.4	neutral	2	1	deleterious	0.04	neutral	1	deleterious	0.67	deleterious	-2.64	low_impact	-0.47	medium_impact	1.49	medium_impact	0.74	0.9	1.56	6.65	0.38	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7263	7263	T	C	MI.4793	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1360	454	S	P	Tca/Cca	-20	0	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-5.11	neutral	-1.72	high_impact	3.77	0.38	damaging	0.21	damaging	4.14	23.80	deleterious	0.14	0.55	0.71	disease	0.82	disease	0.73	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.38	high_impact	0.77	0.9	1.56	6.65	0.44	N	0.91	polymorphism	0.96	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7264	7264	C	T	MI.4794	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1361	454	S	L	tCa/tTa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.82	deleterious	-4.68	neutral	-2.06	high_impact	4.57	0.5	damaging	0.13	damaging	4.78	24.70	deleterious	0.12	0.55	0.57	disease	0.85	disease	0.63	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.12	high_impact	0.80	0.9	1.56	6.65	0.54	P	0.90	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7264	7264	C	G	MI.4795	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1361	454	S	W	tCa/tGa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.72	deleterious	-7.75	neutral	-2.41	high_impact	4.92	0.49	damaging	0.15	damaging	4.47	24.20	deleterious	0.1	0.55	0.91	disease	0.88	disease	0.71	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.44	high_impact	0.49	0.9	1.56	6.65	0.69	P	0.94	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7266	7266	T	G	MI.4796	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1363	455	S	A	Tct/Gct	-7.55	0	0	probably_damaging	0.98	deleterious	0	neutral	2.71	neutral	-2.73	neutral	-0.9	high_impact	4.86	0.6	neutral	0.19	damaging	3.89	23.50	deleterious	0.31	0.55	0.36	neutral	0.57	disease	0.69	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.71	deleterious	-2.35	low_impact	-1.48	low_impact	3.39	high_impact	0.72	0.9	2.73	7.32	0.65	P	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7266	7266	T	C	MI.4797	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1363	455	S	P	Tct/Cct	-7.55	0	0	probably_damaging	1	deleterious	0	neutral	2.6	deleterious	-4.87	neutral	-1.53	high_impact	4.51	0.49	damaging	0.15	damaging	4.11	23.80	deleterious	0.18	0.55	0.77	disease	0.83	disease	0.8	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.07	high_impact	0.72	0.9	2.73	7.32	0.51	N	0.91	polymorphism	0.98	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7266	7266	T	A	MI.4798	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1363	455	S	T	Tct/Act	-7.55	0	0	probably_damaging	0.97	neutral	0.14	neutral	2.85	deleterious	-3.12	neutral	-0.59	low_impact	1.86	0.52	damaging	0.26	damaging	2.85	21.60	deleterious	0.24	0.55	0.24	neutral	0.49	neutral	0.47	neutral	0.42	neutral	2	0.99	deleterious	0.09	neutral	-2	neutral	0.65	deleterious	-2.18	low_impact	-0.25	medium_impact	0.62	medium_impact	0.79	0.9	2.73	7.32	0.41	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7267	7267	C	A	MI.4799	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1364	455	S	Y	tCt/tAt	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-4.24	neutral	-1.87	high_impact	4.86	0.55	damaging	0.13	damaging	4.24	23.90	deleterious	0.16	0.55	0.32	neutral	0.86	disease	0.71	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	3.39	high_impact	0.70	0.9	2.73	7.32	0.65	P	0.92	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8546	8546	C	A	MI.48	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	20	7	A	D	gCt/gAt	-0.33	0	0	benign	0.19	neutral	0.85	neutral	4.73	neutral	-0.32	neutral	0.33	neutral_impact	-0.82	0.73	neutral	0.71	neutral	2.46	19.23	deleterious	0.31	0.65	0.34	neutral	0.12	neutral	0.27	neutral	0.22	neutral	6	0.09	neutral	0.83	deleterious	-6	neutral	0.36	neutral	-0.16	medium_impact	0.72	medium_impact	-1.8	low_impact	0.54	0.9	9.29	10.06	0.31	N	0.96	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8753	8753	T	G	MI.480	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	227	76	I	S	aTc/aGc	4.76	0.99	0	probably_damaging	0.99	neutral	0.05	neutral	4.26	deleterious	-3.57	deleterious	-3.6	low_impact	1.8	0.84	neutral	0.42	neutral	4.17	23.80	deleterious	0.22	0.65	0.78	disease	0.69	disease	0.51	disease	0.59	disease	2	1	deleterious	0.03	neutral	-2	neutral	0.77	deleterious	-2.65	low_impact	-0.43	medium_impact	0.45	medium_impact	0.49	0.9	18.58	16.92	0.48	N	0.98	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7267	7267	C	T	MI.4800	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1364	455	S	F	tCt/tTt	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.67	deleterious	-3.81	neutral	-1.87	high_impact	4.51	0.44	damaging	0.08	damaging	4.25	23.90	deleterious	0.14	0.55	0.77	disease	0.9	disease	0.71	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.07	high_impact	0.48	0.9	2.73	7.32	0.62	P	0.98	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7267	7267	C	G	MI.4801	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1364	455	S	C	tCt/tGt	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.6	neutral	-0.92	neutral	-1.53	high_impact	4.51	0.55	damaging	0.12	damaging	3.70	23.30	deleterious	0.21	0.55	0.83	disease	0.82	disease	0.67	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	3.07	high_impact	0.61	0.9	2.73	7.32	0.48	P	0.85	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7269	7269	G	C	MI.4802	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1366	456	V	L	Gta/Cta	-20	0	0	benign	0.02	neutral	0.38	neutral	2.83	neutral	2.66	neutral	0.05	neutral_impact	-1.09	0.73	neutral	0.81	neutral	-0.21	1.04	neutral	0.52	0.6	0.27	neutral	0.24	neutral	0.22	neutral	0.43	neutral	1	0.6	neutral	0.68	deleterious	-6	neutral	0.16	neutral	0.83	medium_impact	0.07	medium_impact	-2.11	low_impact	0.85	0.9	15.01	35.33	0.49	N	0.06	polymorphism	1	0.01	rs386829004	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7269	7269	G	A	MI.4803	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1366	456	V	M	Gta/Ata	-20	0	0	benign	0.02	neutral	0.31	neutral	2.6	neutral	0.41	neutral	-0.17	neutral_impact	0.03	0.77	neutral	0.95	neutral	0.31	5.84	deleterious	0.48	0.55	0.37	neutral	0.18	neutral	0.22	neutral	0.35	neutral	3	0.68	neutral	0.65	deleterious	-6	neutral	0.15	neutral	0.83	medium_impact	0	medium_impact	-1.07	low_impact	0.87	0.9	15.01	35.33	0.44	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7269	7269	G	T	MI.4804	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1366	456	V	L	Gta/Tta	-20	0	0	benign	0.02	neutral	0.38	neutral	2.83	neutral	2.66	neutral	0.05	neutral_impact	-1.09	0.73	neutral	0.81	neutral	-0.10	1.71	neutral	0.52	0.6	0.27	neutral	0.24	neutral	0.22	neutral	0.43	neutral	1	0.6	neutral	0.68	deleterious	-6	neutral	0.16	neutral	0.83	medium_impact	0.07	medium_impact	-2.11	low_impact	0.85	0.9	15.01	35.33	0.49	N	0.06	polymorphism	1	0.01	rs386829004	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7270	7270	T	A	MI.4805	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1367	456	V	E	gTa/gAa	1.21	0.31	0.02	benign	0.38	deleterious	0	neutral	2.56	neutral	-2.89	neutral	-1.61	medium_impact	2.71	0.64	neutral	0.52	neutral	3.00	22.20	deleterious	0.15	0.55	0.7	disease	0.79	disease	0.64	disease	0.78	disease	6	1	deleterious	0.31	neutral	1	deleterious	0.44	deleterious	-0.56	medium_impact	-1.48	low_impact	1.4	medium_impact	0.59	0.9	15.01	35.33	0.29	N	0.24	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7270	7270	T	G	MI.4806	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1367	456	V	G	gTa/gGa	1.21	0.31	0.02	benign	0.2	deleterious	0.02	neutral	2.62	deleterious	-3.32	neutral	-1.92	medium_impact	2.71	0.68	neutral	0.55	neutral	2.20	17.51	deleterious	0.22	0.55	0.67	disease	0.57	disease	0.51	disease	0.57	disease	1	0.98	neutral	0.41	neutral	1	deleterious	0.35	neutral	-0.19	medium_impact	-0.75	medium_impact	1.4	medium_impact	0.63	0.9	15.01	35.33	0.35	N	0.23	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7270	7270	T	C	MI.4807	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1367	456	V	A	gTa/gCa	1.21	0.31	0.02	benign	0.13	deleterious	0	neutral	2.66	neutral	-1.52	neutral	-1	low_impact	1.32	0.71	neutral	0.91	neutral	1.79	14.92	neutral	0.41	0.55	0.41	neutral	0.31	neutral	0.48	neutral	0.47	neutral	1	1	deleterious	0.44	neutral	-2	neutral	0.22	neutral	0.02	medium_impact	-1.48	low_impact	0.12	medium_impact	0.52	0.9	15.01	35.33	0.42	N	0.00	polymorphism	1	0.03	rs879002867	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7272	7272	G	T	MI.4808	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1369	457	G	C	Ggc/Tgc	-2.48	0	0	probably_damaging	1	deleterious	0	neutral	1.87	deleterious	-7.42	deleterious	-3.07	high_impact	5	0.39	damaging	0.02	damaging	4.25	23.90	deleterious	0.14	0.55	0.9	disease	0.88	disease	0.7	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.57	0.9	3.31	6.61	0.52	P	0.98	polymorphism	0.82	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7272	7272	G	C	MI.4809	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1369	457	G	R	Ggc/Cgc	-2.48	0	0	probably_damaging	1	deleterious	0	neutral	1.87	deleterious	-6.4	deleterious	-2.73	high_impact	4.66	0.44	damaging	0.02	damaging	4.06	23.70	deleterious	0.11	0.55	0.92	disease	0.86	disease	0.8	disease	0.88	disease	8	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.58	low_impact	-1.48	low_impact	3.2	high_impact	0.62	0.9	3.31	6.61	0.54	P	0.95	polymorphism	0.9	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8753	8753	T	C	MI.481	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	227	76	I	T	aTc/aCc	4.76	0.99	0	probably_damaging	0.99	deleterious	0	neutral	4.27	neutral	-2.85	deleterious	-2.94	low_impact	0.98	0.92	neutral	0.74	neutral	3.33	22.90	deleterious	0.3	0.65	0.72	disease	0.38	neutral	0.45	neutral	0.65	disease	3	1	deleterious	0.01	neutral	2	deleterious	0.73	deleterious	-2.65	low_impact	-1.4	low_impact	-0.26	medium_impact	0.56	0.9	18.58	16.92	0.53	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7272	7272	G	A	MI.4810	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1369	457	G	S	Ggc/Agc	-2.48	0	0	probably_damaging	1	deleterious	0	neutral	1.96	deleterious	-5.1	neutral	-2.05	high_impact	3.68	0.47	damaging	0.03	damaging	4.34	24.00	deleterious	0.16	0.55	0.6	disease	0.81	disease	0.62	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-1.48	low_impact	2.3	high_impact	0.51	0.9	3.31	6.61	0.3	N	0.73	polymorphism	0.95	0.14	rs28415137	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7273	7273	G	T	MI.4811	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1370	457	G	V	gGc/gTc	9.29	1	0	probably_damaging	1	deleterious	0	neutral	1.89	deleterious	-6.19	deleterious	-3.07	high_impact	4.3	0.48	damaging	0.03	damaging	3.91	23.50	deleterious	0.14	0.55	0.85	disease	0.85	disease	0.69	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.87	high_impact	0.48	0.9	3.31	6.61	0.48	N	0.93	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7273	7273	G	C	MI.4812	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1370	457	G	A	gGc/gCc	9.29	1	0	probably_damaging	1	deleterious	0	neutral	2.04	deleterious	-4.83	neutral	-2.05	high_impact	4.03	0.58	damaging	0.04	damaging	3.27	22.80	deleterious	0.18	0.55	0.35	neutral	0.66	disease	0.62	disease	0.67	disease	3	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.62	high_impact	0.64	0.9	3.31	6.61	0.44	N	0.64	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7273	7273	G	A	MI.4813	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1370	457	G	D	gGc/gAc	9.29	1	0	probably_damaging	1	deleterious	0	neutral	1.88	deleterious	-5.9	neutral	-2.39	high_impact	5	0.29	damaging	0.02	damaging	4.02	23.60	deleterious	0.13	0.55	0.9	disease	0.86	disease	0.77	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.52	high_impact	0.48	0.9	3.31	6.61	0.82	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	COSM1319393	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7275	7275	T	G	MI.4814	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1372	458	S	A	Tca/Gca	-9.62	0	0	probably_damaging	0.98	deleterious	0.02	neutral	2.94	neutral	-2.98	neutral	-0.94	medium_impact	2.31	0.56	damaging	0.29	neutral	1.90	15.60	deleterious	0.41	0.55	0.19	neutral	0.52	disease	0.36	neutral	0.42	neutral	2	1	deleterious	0.02	neutral	5	deleterious	0.65	deleterious	-2.35	low_impact	-0.75	medium_impact	1.03	medium_impact	0.79	0.9	1.95	6.79	0.39	N	0.35	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7275	7275	T	A	MI.4815	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1372	458	S	T	Tca/Aca	-9.62	0	0	probably_damaging	0.97	deleterious	0	neutral	2.76	deleterious	-3.75	neutral	-0.99	high_impact	3.83	0.46	damaging	0.06	damaging	2.13	17.06	deleterious	0.32	0.55	0.55	disease	0.64	disease	0.49	neutral	0.47	neutral	1	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.18	low_impact	-1.48	low_impact	2.44	high_impact	0.84	0.9	1.95	6.79	0.37	N	0.43	polymorphism	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7275	7275	T	C	MI.4816	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1372	458	S	P	Tca/Cca	-9.62	0	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-5.11	neutral	-1.66	high_impact	4.32	0.24	damaging	0.06	damaging	3.86	23.50	deleterious	0.16	0.55	0.75	disease	0.85	disease	0.7	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	2.89	high_impact	0.75	0.9	1.95	6.79	0.66	P	0.91	disease_causing_automatic	0.12	0.18	rs267606884	Pathogenic	Familial_colorectal_cancer	24712	MedGen:CN029768	colonic crypts	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	7276	7276	C	G	MI.4817	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1373	458	S	W	tCa/tGa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.7	deleterious	-7.75	neutral	-2.34	high_impact	4.87	0.42	damaging	0.04	damaging	4.49	24.30	deleterious	0.13	0.55	0.94	disease	0.9	disease	0.63	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.58	low_impact	-1.48	low_impact	3.4	high_impact	0.49	0.9	1.95	6.79	0.65	P	0.94	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7276	7276	C	T	MI.4818	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1373	458	S	L	tCa/tTa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.71	deleterious	-4.68	neutral	-1.99	high_impact	4.17	0.5	damaging	0.03	damaging	4.44	24.20	deleterious	0.18	0.55	0.7	disease	0.87	disease	0.55	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.75	high_impact	0.90	0.95	1.95	6.79	0.5	P	0.90	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7278	7278	T	A	MI.4819	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1375	459	F	I	Ttc/Atc	-8.7	0	0	benign	0.11	neutral	0.28	neutral	2.75	neutral	2.29	neutral	0.3	neutral_impact	-0.12	0.73	neutral	0.7	neutral	1.27	12.12	neutral	0.27	0.55	0.31	neutral	0.38	neutral	0.22	neutral	0.44	neutral	1	0.68	neutral	0.59	deleterious	-6	neutral	0.26	neutral	0.1	medium_impact	-0.04	medium_impact	-1.21	low_impact	0.75	0.9	3.9	9.36	0.43	N	0.88	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8753	8753	T	A	MI.482	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	227	76	I	N	aTc/aAc	4.76	0.99	0	probably_damaging	1	deleterious	0	neutral	4.26	deleterious	-4.66	deleterious	-4.54	medium_impact	2.14	0.85	neutral	0.39	neutral	4.47	24.20	deleterious	0.2	0.65	0.88	disease	0.75	disease	0.54	disease	0.75	disease	5	1	deleterious	0	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	0.74	medium_impact	0.62	0.9	18.58	16.92	0.46	N	1.00	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7278	7278	T	C	MI.4820	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1375	459	F	L	Ttc/Ctc	-8.7	0	0	benign	0	neutral	1	neutral	2.83	neutral	2.5	neutral	0.4	neutral_impact	-0.44	0.71	neutral	0.72	neutral	-0.19	1.16	neutral	0.42	0.55	0.23	neutral	0.22	neutral	0.18	neutral	0.41	neutral	2	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	1.86	high_impact	-1.51	low_impact	0.77	0.9	3.9	9.36	0.42	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7278	7278	T	G	MI.4821	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1375	459	F	V	Ttc/Gtc	-8.7	0	0	benign	0.32	neutral	0.07	neutral	2.85	neutral	1.83	neutral	0.2	low_impact	0.92	0.69	neutral	0.58	neutral	2.81	21.40	deleterious	0.33	0.55	0.21	neutral	0.51	disease	0.28	neutral	0.43	neutral	1	0.92	neutral	0.38	neutral	-6	neutral	0.27	neutral	-0.45	medium_impact	-0.43	medium_impact	-0.25	medium_impact	0.79	0.9	3.9	9.36	0.49	N	0.84	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7279	7279	T	A	MI.4822	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1376	459	F	Y	tTc/tAc	0.06	0.04	0	benign	0.37	neutral	0.11	neutral	2.65	neutral	-1.03	neutral	-0.08	neutral_impact	0.43	0.67	neutral	0.64	neutral	0.93	10.27	neutral	0.45	0.55	0.47	neutral	0.26	neutral	0.24	neutral	0.42	neutral	2	0.87	neutral	0.37	neutral	-6	neutral	0.44	deleterious	-0.54	medium_impact	-0.31	medium_impact	-0.7	medium_impact	0.74	0.9	3.9	9.36	0.51	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7279	7279	T	C	MI.4823	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1376	459	F	S	tTc/tCc	0.06	0.04	0	possibly_damaging	0.78	neutral	0.07	neutral	2.73	neutral	-0.35	neutral	-0.4	medium_impact	2.74	0.62	neutral	0.64	neutral	3.02	22.30	deleterious	0.33	0.55	0.43	neutral	0.49	neutral	0.43	neutral	0.47	neutral	1	0.95	neutral	0.15	neutral	0	NA	0.62	deleterious	-1.27	low_impact	-0.43	medium_impact	1.43	medium_impact	0.65	0.9	3.9	9.36	0.51	P	0.84	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7279	7279	T	G	MI.4824	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1376	459	F	C	tTc/tGc	0.06	0.04	0	probably_damaging	0.94	deleterious	0.01	neutral	2.63	neutral	-1.69	neutral	-0.45	medium_impact	2.4	0.59	damaging	0.44	neutral	4.21	23.90	deleterious	0.25	0.55	0.69	disease	0.69	disease	0.43	neutral	0.5	neutral	0	1	deleterious	0.04	neutral	5	deleterious	0.75	deleterious	-1.88	low_impact	-0.92	medium_impact	1.12	medium_impact	0.50	0.9	3.9	9.36	0.4	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7280	7280	C	A	MI.4825	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1377	459	F	L	ttC/ttA	5.6	0.87	0.01	benign	0	neutral	1	neutral	2.83	neutral	2.5	neutral	0.4	neutral_impact	-0.44	0.71	neutral	0.72	neutral	0.43	6.86	deleterious	0.42	0.55	0.23	neutral	0.22	neutral	0.18	neutral	0.41	neutral	2	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	1.86	high_impact	-1.51	low_impact	0.77	0.9	3.9	9.36	0.46	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7280	7280	C	G	MI.4826	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1377	459	F	L	ttC/ttG	5.6	0.87	0.01	benign	0	neutral	1	neutral	2.83	neutral	2.5	neutral	0.4	neutral_impact	-0.44	0.71	neutral	0.72	neutral	0.09	3.51	deleterious	0.42	0.55	0.23	neutral	0.22	neutral	0.18	neutral	0.41	neutral	2	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	1.86	high_impact	-1.51	low_impact	0.77	0.9	3.9	9.36	0.46	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7281	7281	A	C	MI.4827	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1378	460	I	L	Att/Ctt	-5.01	0	0	benign	0.06	neutral	0.12	neutral	2.91	neutral	-0.33	neutral	-0.48	low_impact	1.24	0.66	neutral	0.17	damaging	0.87	9.89	deleterious	0.3	0.55	0.21	neutral	0.51	disease	0.29	neutral	0.42	neutral	2	0.87	neutral	0.53	deleterious	-6	neutral	0.16	neutral	0.37	medium_impact	-0.29	medium_impact	0.05	medium_impact	0.68	0.9	6.63	13.2	0.42	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7281	7281	A	T	MI.4828	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1378	460	I	F	Att/Ttt	-5.01	0	0	possibly_damaging	0.55	deleterious	0.03	neutral	2.58	neutral	-2.9	neutral	-1.15	medium_impact	3.06	0.61	neutral	0.09	damaging	2.29	18.09	deleterious	0.3	0.55	0.52	disease	0.78	disease	0.49	neutral	0.59	disease	2	0.97	neutral	0.24	neutral	4	deleterious	0.64	deleterious	-0.84	medium_impact	-0.65	medium_impact	1.73	medium_impact	0.72	0.9	6.63	13.2	0.26	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7281	7281	A	G	MI.4829	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1378	460	I	V	Att/Gtt	-5.01	0	0	benign	0.06	neutral	0.15	neutral	2.72	neutral	-1.38	neutral	-0.27	low_impact	1.82	0.65	neutral	0.41	neutral	0.22	4.87	deleterious	0.51	0.6	0.36	neutral	0.34	neutral	0.35	neutral	0.43	neutral	1	0.84	neutral	0.55	deleterious	-6	neutral	0.17	neutral	0.37	medium_impact	-0.23	medium_impact	0.58	medium_impact	0.62	0.9	6.63	13.2	0.47	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8754	8754	C	A	MI.483	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	228	76	I	M	atC/atA	3.14	0.99	0	probably_damaging	1	neutral	0.53	neutral	4.35	neutral	-0.48	neutral	-0.07	neutral_impact	-1.35	0.81	neutral	0.74	neutral	1.05	10.94	neutral	0.3	0.65	0.52	disease	0.08	neutral	0.22	neutral	0.25	neutral	5	0.99	deleterious	0.27	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.32	medium_impact	-2.25	low_impact	0.56	0.9	18.58	16.92	0.37	N	0.75	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7282	7282	T	G	MI.4830	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1379	460	I	S	aTt/aGt	3.98	0.99	0	probably_damaging	0.95	deleterious	0	neutral	2.53	deleterious	-4.53	neutral	-1.77	high_impact	4.21	0.66	neutral	0.15	damaging	4.32	24.00	deleterious	0.26	0.55	0.68	disease	0.84	disease	0.55	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.78	deleterious	-1.96	low_impact	-1.48	low_impact	2.79	high_impact	0.59	0.9	6.63	13.2	0.44	N	0.65	disease_causing	0.62	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7282	7282	T	A	MI.4831	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1379	460	I	N	aTt/aAt	3.98	0.99	0	probably_damaging	0.99	deleterious	0	neutral	2.52	deleterious	-5.65	neutral	-2.11	high_impact	4.21	0.63	neutral	0.11	damaging	4.51	24.30	deleterious	0.23	0.55	0.82	disease	0.78	disease	0.57	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.64	low_impact	-1.48	low_impact	2.79	high_impact	0.70	0.9	6.63	13.2	0.44	N	0.95	disease_causing	0.56	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7282	7282	T	C	MI.4832	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1379	460	I	T	aTt/aCt	3.98	0.99	0	probably_damaging	0.95	deleterious	0	neutral	2.54	deleterious	-4	neutral	-1.46	high_impact	3.86	0.66	neutral	0.14	damaging	3.36	22.90	deleterious	0.31	0.55	0.62	disease	0.66	disease	0.55	disease	0.58	disease	2	1	deleterious	0.03	neutral	6	deleterious	0.69	deleterious	-1.96	low_impact	-1.48	low_impact	2.47	high_impact	0.66	0.9	6.63	13.2	0.45	N	0.79	polymorphism	0.71	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7283	7283	T	G	MI.4833	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1380	460	I	M	atT/atG	5.83	1	0	benign	0.06	neutral	0.11	neutral	2.61	neutral	-2.44	neutral	-0.66	low_impact	1.82	0.66	neutral	0.26	damaging	0.53	7.66	deleterious	0.36	0.55	0.4	neutral	0.48	neutral	0.31	neutral	0.46	neutral	1	0.88	neutral	0.53	deleterious	-6	neutral	0.18	neutral	0.37	medium_impact	-0.31	medium_impact	0.58	medium_impact	0.78	0.9	6.63	13.2	0.59	P	0.73	disease_causing	0.58	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7283	7283	T	A	MI.4834	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1380	460	I	M	atT/atA	5.83	1	0	benign	0.06	neutral	0.11	neutral	2.61	neutral	-2.44	neutral	-0.66	low_impact	1.82	0.66	neutral	0.26	damaging	0.74	9.11	deleterious	0.36	0.55	0.4	neutral	0.48	neutral	0.31	neutral	0.46	neutral	1	0.88	neutral	0.53	deleterious	-6	neutral	0.18	neutral	0.37	medium_impact	-0.31	medium_impact	0.58	medium_impact	0.78	0.9	6.63	13.2	0.6	P	0.73	disease_causing	0.58	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7284	7284	T	C	MI.4835	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1381	461	S	P	Tct/Cct	-8.01	0	0	probably_damaging	0.99	deleterious	0	neutral	2.8	neutral	-1.82	neutral	-1.64	high_impact	4.75	0.41	damaging	0.48	neutral	4.10	23.70	deleterious	0.17	0.55	0.66	disease	0.85	disease	0.74	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.64	low_impact	-1.48	low_impact	3.29	high_impact	0.73	0.9	NA	NA	0.78	P	0.91	polymorphism	0.96	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7284	7284	T	G	MI.4836	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1381	461	S	A	Tct/Gct	-8.01	0	0	probably_damaging	0.97	deleterious	0.01	neutral	2.91	neutral	0.41	neutral	-0.98	high_impact	3.64	0.59	damaging	0.5	neutral	3.86	23.50	deleterious	0.38	0.55	0.32	neutral	0.56	disease	0.54	disease	0.46	neutral	1	1	deleterious	0.02	neutral	6	deleterious	0.69	deleterious	-2.18	low_impact	-0.92	medium_impact	2.26	high_impact	0.75	0.9	NA	NA	0.45	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7284	7284	T	A	MI.4837	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1381	461	S	T	Tct/Act	-8.01	0	0	probably_damaging	0.95	neutral	0.06	neutral	2.86	neutral	2.48	neutral	-0.9	medium_impact	2.44	0.5	damaging	0.46	neutral	3.92	23.50	deleterious	0.29	0.55	0.25	neutral	0.54	disease	0.39	neutral	0.44	neutral	1	0.99	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-1.96	low_impact	-0.47	medium_impact	1.15	medium_impact	0.86	0.9	NA	NA	0.5	N	0.42	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7285	7285	C	T	MI.4838	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1382	461	S	F	tCt/tTt	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.92	neutral	-1.71	neutral	-1.97	high_impact	3.6	0.39	damaging	0.38	neutral	4.33	24.00	deleterious	0.17	0.55	0.45	neutral	0.89	disease	0.63	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.61	0.9	NA	NA	0.73	P	0.98	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7285	7285	C	A	MI.4839	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1382	461	S	Y	tCt/tAt	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.86	neutral	-2.11	neutral	-1.97	high_impact	4.75	0.43	damaging	0.39	neutral	4.16	23.80	deleterious	0.18	0.55	0.52	disease	0.86	disease	0.65	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.81	0.9	NA	NA	0.8	P	0.92	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8754	8754	C	G	MI.484	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	228	76	I	M	atC/atG	3.14	0.99	0	probably_damaging	1	neutral	0.53	neutral	4.35	neutral	-0.48	neutral	-0.07	neutral_impact	-1.35	0.81	neutral	0.74	neutral	0.55	7.79	deleterious	0.3	0.65	0.52	disease	0.08	neutral	0.22	neutral	0.25	neutral	5	0.99	deleterious	0.27	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.32	medium_impact	-2.25	low_impact	0.56	0.9	18.58	16.92	0.37	N	0.75	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7285	7285	C	G	MI.4840	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1382	461	S	C	tCt/tGt	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.79	neutral	-2.4	neutral	-1.64	high_impact	4.75	0.48	damaging	0.41	neutral	3.75	23.30	deleterious	0.24	0.55	0.64	disease	0.81	disease	0.61	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.58	low_impact	-1.48	low_impact	3.29	high_impact	0.75	0.9	NA	NA	0.7	P	0.84	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7287	7287	C	A	MI.4841	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1384	462	L	M	Cta/Ata	-7.09	0	0	benign	0.05	neutral	0.29	neutral	2.76	neutral	-1.84	neutral	-0.1	low_impact	1.15	0.7	neutral	0.31	neutral	0.41	6.73	deleterious	0.33	0.55	0.46	neutral	0.26	neutral	0.23	neutral	0.46	neutral	1	0.69	neutral	0.62	deleterious	-6	neutral	0.14	neutral	0.45	medium_impact	-0.02	medium_impact	-0.04	medium_impact	0.74	0.9	3.12	8.28	0.45	N	0.55	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7287	7287	C	G	MI.4842	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1384	462	L	V	Cta/Gta	-7.09	0	0	benign	0.08	neutral	0.23	neutral	2.87	neutral	0.14	neutral	-0.43	medium_impact	2.92	0.61	neutral	0.14	damaging	0.30	5.67	deleterious	0.4	0.55	0.27	neutral	0.4	neutral	0.23	neutral	0.45	neutral	1	0.74	neutral	0.58	deleterious	-3	neutral	0.14	neutral	0.24	medium_impact	-0.1	medium_impact	1.6	medium_impact	0.70	0.9	3.12	8.28	0.48	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7288	7288	T	A	MI.4843	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1385	462	L	Q	cTa/cAa	-0.17	0	0	probably_damaging	0.96	deleterious	0	neutral	2.74	deleterious	-3.79	neutral	-1.22	medium_impact	3.46	0.63	neutral	0.11	damaging	4.07	23.70	deleterious	0.21	0.55	0.61	disease	0.68	disease	0.44	neutral	0.5	neutral	0	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-2.06	low_impact	-1.48	low_impact	2.1	high_impact	0.70	0.9	3.12	8.28	0.32	N	0.84	polymorphism	0.71	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7288	7288	T	G	MI.4844	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1385	462	L	R	cTa/cGa	-0.17	0	0	probably_damaging	0.96	deleterious	0	neutral	2.75	deleterious	-3.63	neutral	-1.29	medium_impact	3.46	0.58	damaging	0.09	damaging	4.18	23.80	deleterious	0.19	0.55	0.59	disease	0.87	disease	0.59	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-2.06	low_impact	-1.48	low_impact	2.1	high_impact	0.71	0.9	3.12	8.28	0.27	N	0.88	polymorphism	0.67	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7288	7288	T	C	MI.4845	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1385	462	L	P	cTa/cCa	-0.17	0	0	probably_damaging	0.99	deleterious	0	neutral	2.74	deleterious	-4.35	neutral	-1.55	medium_impact	3.46	0.52	damaging	0.1	damaging	3.94	23.50	deleterious	0.18	0.55	0.7	disease	0.84	disease	0.66	disease	0.77	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	2.1	high_impact	0.56	0.9	3.12	8.28	0.27	N	0.86	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7290	7290	A	C	MI.4846	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1387	463	T	P	Aca/Cca	-1.32	0	0	benign	0.13	deleterious	0	neutral	2.96	neutral	-1.83	neutral	-0.74	medium_impact	3.15	0.57	damaging	0.32	neutral	1.79	14.91	neutral	0.14	0.55	0.6	disease	0.8	disease	0.62	disease	0.78	disease	6	1	deleterious	0.44	neutral	1	deleterious	0.28	neutral	0.02	medium_impact	-1.48	low_impact	1.81	medium_impact	0.56	0.9	12.67	43.62	0.33	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7290	7290	A	T	MI.4847	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1387	463	T	S	Aca/Tca	-1.32	0	0	benign	0.01	deleterious	0	neutral	2.99	neutral	-0.54	neutral	-0.36	low_impact	1.64	0.68	neutral	0.51	neutral	1.41	12.82	neutral	0.4	0.55	0.37	neutral	0.43	neutral	0.38	neutral	0.47	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.12	neutral	1.12	medium_impact	-1.48	low_impact	0.42	medium_impact	0.65	0.9	12.67	43.62	0.49	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7290	7290	A	G	MI.4848	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1387	463	T	A	Aca/Gca	-1.32	0	0	benign	0	deleterious	0.03	neutral	3.08	neutral	0.34	neutral	-0.09	low_impact	1.64	0.75	neutral	0.6	neutral	0.46	7.13	deleterious	0.46	0.55	0.2	neutral	0.34	neutral	0.39	neutral	0.44	neutral	1	0.97	neutral	0.52	deleterious	-2	neutral	0.08	neutral	2.07	high_impact	-0.65	medium_impact	0.42	medium_impact	0.44	0.9	12.67	43.62	0.5	N	0.63	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7291	7291	C	T	MI.4849	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1388	463	T	M	aCa/aTa	0.06	0	0	benign	0.01	neutral	0.08	neutral	2.98	neutral	2.64	neutral	0.52	neutral_impact	0.46	0.69	neutral	0.67	neutral	0.87	9.89	deleterious	0.31	0.55	0.27	neutral	0.35	neutral	0.26	neutral	0.45	neutral	1	0.92	neutral	0.54	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	-0.4	medium_impact	-0.67	medium_impact	0.72	0.9	12.67	43.62	0.51	N	0.80	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8755	8755	A	G	MI.485	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	229	77	I	V	Att/Gtt	-2.65	0	0	benign	0.03	neutral	0.35	neutral	4.45	neutral	-0.59	neutral	-0.41	neutral_impact	0.09	0.83	neutral	0.8	neutral	-0.60	0.13	neutral	0.39	0.65	0.34	neutral	0.14	neutral	0.36	neutral	0.29	neutral	4	0.63	neutral	0.66	deleterious	-6	neutral	0.13	neutral	0.68	medium_impact	0.14	medium_impact	-1.02	low_impact	0.51	0.9	27.43	20.89	0.42	N	0.38	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7291	7291	C	A	MI.4850	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1388	463	T	K	aCa/aAa	0.06	0	0	benign	0.03	deleterious	0	neutral	2.96	neutral	-0.96	neutral	-0.58	medium_impact	3.15	0.65	neutral	0.35	neutral	2.71	20.80	deleterious	0.22	0.55	0.49	neutral	0.73	disease	0.63	disease	0.74	disease	5	1	deleterious	0.49	deleterious	1	deleterious	0.24	neutral	0.66	medium_impact	-1.48	low_impact	1.81	medium_impact	0.71	0.9	12.67	43.62	0.38	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7293	7293	G	T	MI.4851	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1390	464	A	S	Gca/Tca	-2.94	0	0	probably_damaging	0.99	neutral	0.49	neutral	3.05	neutral	0.23	neutral	0.17	neutral_impact	0.66	0.54	damaging	0.11	damaging	1.82	15.12	deleterious	0.41	0.55	0.19	neutral	0.2	neutral	0.27	neutral	0.35	neutral	3	0.99	deleterious	0.25	neutral	-2	neutral	0.63	deleterious	-2.64	low_impact	0.18	medium_impact	-0.49	medium_impact	0.87	0.9	1.95	6.68	0.34	N	0.61	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7293	7293	G	C	MI.4852	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1390	464	A	P	Gca/Cca	-2.94	0	0	probably_damaging	1	deleterious	0	neutral	2.66	deleterious	-5.35	neutral	-0.93	high_impact	4.05	0.52	damaging	0.04	damaging	4.03	23.60	deleterious	0.11	0.55	0.71	disease	0.91	disease	0.73	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.64	high_impact	0.84	0.9	1.95	6.68	0.33	N	0.85	polymorphism	0.96	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7293	7293	G	A	MI.4853	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1390	464	A	T	Gca/Aca	-2.94	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.67	deleterious	-4.15	neutral	-0.46	high_impact	3.71	0.57	damaging	0.06	damaging	4.31	24.00	deleterious	0.39	0.55	0.51	disease	0.64	disease	0.54	disease	0.59	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-0.92	medium_impact	2.33	high_impact	0.74	0.9	1.95	6.68	0.32	N	0.23	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7294	7294	C	T	MI.4854	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1391	464	A	V	gCa/gTa	9.29	1	0	probably_damaging	0.99	deleterious	0	neutral	2.68	deleterious	-3.88	neutral	-1.05	high_impact	4.05	0.55	damaging	0.04	damaging	4.54	24.30	deleterious	0.34	0.55	0.66	disease	0.82	disease	0.62	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.64	low_impact	-1.48	low_impact	2.64	high_impact	0.73	0.9	1.95	6.68	0.51	P	0.75	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7294	7294	C	A	MI.4855	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1391	464	A	E	gCa/gAa	9.29	1	0	probably_damaging	1	deleterious	0.01	neutral	2.65	deleterious	-5.95	neutral	-0.78	high_impact	4.05	0.56	damaging	0.06	damaging	4.64	24.50	deleterious	0.16	0.55	0.76	disease	0.9	disease	0.74	disease	0.83	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.58	low_impact	-0.92	medium_impact	2.64	high_impact	0.81	0.9	1.95	6.68	0.5	P	0.77	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7294	7294	C	G	MI.4856	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1391	464	A	G	gCa/gGa	9.29	1	0	probably_damaging	0.97	neutral	0.3	neutral	3.49	neutral	1.52	neutral	-0.04	low_impact	1.46	0.54	damaging	0.12	damaging	2.28	18.01	deleterious	0.23	0.55	0.29	neutral	0.39	neutral	0.33	neutral	0.44	neutral	1	0.98	neutral	0.17	neutral	-2	neutral	0.64	deleterious	-2.18	low_impact	-0.01	medium_impact	0.25	medium_impact	0.81	0.9	1.95	6.68	0.6	P	0.56	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7296	7296	G	A	MI.4857	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1393	465	V	M	Gta/Ata	-8.93	0	0	benign	0.02	neutral	0.13	neutral	2.91	neutral	-0.54	neutral	-0.55	low_impact	1.82	0.65	neutral	0.66	neutral	0.74	9.07	deleterious	0.47	0.55	0.45	neutral	0.58	disease	0.33	neutral	0.49	neutral	0	0.87	neutral	0.56	deleterious	-6	neutral	0.13	neutral	0.83	medium_impact	-0.27	medium_impact	0.58	medium_impact	0.90	0.95	10.33	43.73	0.47	N	0.77	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7296	7296	G	C	MI.4858	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1393	465	V	L	Gta/Cta	-8.93	0	0	benign	0.01	neutral	0.26	neutral	3.01	neutral	3.88	neutral	-0.5	medium_impact	2.1	0.59	damaging	0.59	neutral	0.57	7.92	deleterious	0.43	0.55	0.19	neutral	0.66	disease	0.29	neutral	0.44	neutral	1	0.74	neutral	0.63	deleterious	-3	neutral	0.12	neutral	1.12	medium_impact	-0.06	medium_impact	0.84	medium_impact	0.70	0.9	10.33	43.73	0.45	N	0.55	polymorphism	0.99	0.02	rs28625344	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7296	7296	G	T	MI.4859	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1393	465	V	L	Gta/Tta	-8.93	0	0	benign	0.01	neutral	0.26	neutral	3.01	neutral	3.88	neutral	-0.5	medium_impact	2.1	0.59	damaging	0.59	neutral	0.67	8.62	deleterious	0.43	0.55	0.19	neutral	0.66	disease	0.29	neutral	0.44	neutral	1	0.74	neutral	0.63	deleterious	-3	neutral	0.12	neutral	1.12	medium_impact	-0.06	medium_impact	0.84	medium_impact	0.70	0.9	10.33	43.73	0.47	N	0.55	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8755	8755	A	C	MI.486	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	229	77	I	L	Att/Ctt	-2.65	0	0	benign	0.03	neutral	1	neutral	4.54	neutral	0.37	neutral	0.02	neutral_impact	-0.75	0.87	neutral	0.96	neutral	-0.92	0.02	neutral	0.24	0.65	0.33	neutral	0.2	neutral	0.28	neutral	0.37	neutral	3	0.03	neutral	0.99	deleterious	-6	neutral	0.14	neutral	0.68	medium_impact	1.98	high_impact	-1.74	low_impact	0.55	0.9	27.43	20.89	0.29	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7297	7297	T	C	MI.4860	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1394	465	V	A	gTa/gCa	4.21	1	0	benign	0.2	neutral	0.17	neutral	2.99	neutral	0.55	neutral	-1	medium_impact	2.88	0.62	neutral	0.62	neutral	0.90	10.07	neutral	0.37	0.55	0.34	neutral	0.6	disease	0.4	neutral	0.48	neutral	0	0.8	neutral	0.49	deleterious	-3	neutral	0.21	neutral	-0.19	medium_impact	-0.19	medium_impact	1.56	medium_impact	0.55	0.9	10.33	43.73	0.57	P	0.47	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7297	7297	T	A	MI.4861	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1394	465	V	E	gTa/gAa	4.21	1	0	benign	0.3	deleterious	0	neutral	2.85	neutral	1.62	neutral	-1.66	high_impact	4.24	0.62	neutral	0.49	neutral	3.18	22.70	deleterious	0.18	0.55	0.61	disease	0.91	disease	0.73	disease	0.83	disease	7	1	deleterious	0.35	neutral	2	deleterious	0.37	neutral	-0.41	medium_impact	-1.48	low_impact	2.82	high_impact	0.59	0.9	10.33	43.73	0.46	N	0.83	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7297	7297	T	G	MI.4862	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1394	465	V	G	gTa/gGa	4.21	1	0	benign	0.29	deleterious	0	neutral	2.91	neutral	-0.72	neutral	-1.96	high_impact	3.54	0.63	neutral	0.58	neutral	2.26	17.89	deleterious	0.21	0.55	0.21	neutral	0.81	disease	0.61	disease	0.76	disease	5	1	deleterious	0.36	neutral	2	deleterious	0.40	neutral	-0.39	medium_impact	-1.48	low_impact	2.17	high_impact	0.59	0.9	10.33	43.73	0.51	P	0.72	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7299	7299	A	C	MI.4863	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1396	466	M	L	Ata/Cta	-5.01	0	0	benign	0	neutral	0.53	neutral	3.31	neutral	2.91	neutral	0.2	neutral_impact	0.42	0.76	neutral	0.95	neutral	-1.02	0.01	neutral	0.45	0.55	0.33	neutral	0.48	neutral	0.31	neutral	0.47	neutral	1	0.47	neutral	0.77	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.22	medium_impact	-0.71	medium_impact	0.46	0.9	14.62	41.08	0.38	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7299	7299	A	T	MI.4864	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1396	466	M	L	Ata/Tta	-5.01	0	0	benign	0	neutral	0.53	neutral	3.31	neutral	2.91	neutral	0.2	neutral_impact	0.42	0.76	neutral	0.95	neutral	-0.93	0.02	neutral	0.45	0.55	0.33	neutral	0.48	neutral	0.31	neutral	0.47	neutral	1	0.47	neutral	0.77	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.22	medium_impact	-0.71	medium_impact	0.46	0.9	14.62	41.08	0.38	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7299	7299	A	G	MI.4865	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1396	466	M	V	Ata/Gta	-5.01	0	0	benign	0	neutral	0.21	neutral	3.12	neutral	-0.24	neutral	-0.18	low_impact	1.24	0.79	neutral	0.95	neutral	-0.27	0.78	neutral	0.48	0.55	0.16	neutral	0.7	disease	0.37	neutral	0.53	disease	1	0.79	neutral	0.61	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	-0.13	medium_impact	0.05	medium_impact	0.38	0.9	14.62	41.08	0.35	N	0.18	polymorphism	1	0.01	rs879071265	.	.	.	.	.	COSM1155675	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7300	7300	T	A	MI.4866	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1397	466	M	K	aTa/aAa	4.67	1	0	benign	0.01	deleterious	0	neutral	2.94	neutral	-2.97	neutral	-1.37	medium_impact	3.25	0.62	neutral	0.41	neutral	2.35	18.49	deleterious	0.23	0.55	0.44	neutral	0.89	disease	0.68	disease	0.83	disease	6	1	deleterious	0.5	deleterious	1	deleterious	0.26	neutral	1.12	medium_impact	-1.48	low_impact	1.9	medium_impact	0.44	0.9	14.62	41.08	0.52	P	0.64	disease_causing	0.81	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7300	7300	T	C	MI.4867	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1397	466	M	T	aTa/aCa	4.67	1	0	benign	0.01	deleterious	0.01	neutral	2.97	neutral	-2.03	neutral	-0.98	medium_impact	1.97	0.7	neutral	0.8	neutral	1.24	11.96	neutral	0.35	0.55	0.26	neutral	0.69	disease	0.59	disease	0.7	disease	4	0.99	deleterious	0.5	deleterious	1	deleterious	0.17	neutral	1.12	medium_impact	-0.92	medium_impact	0.72	medium_impact	0.41	0.9	14.62	41.08	0.55	P	0.59	polymorphism	0.65	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7301	7301	A	C	MI.4868	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1398	466	M	I	atA/atC	7.44	1	0	benign	0	neutral	1	neutral	3.12	neutral	0.06	neutral	0.05	neutral_impact	-0.72	0.73	neutral	0.98	neutral	-1.16	0.01	neutral	0.48	0.55	0.2	neutral	0.54	disease	0.33	neutral	0.43	neutral	1	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	1.86	high_impact	-1.76	low_impact	0.54	0.9	14.62	41.08	0.5	N	0.00	disease_causing	0.64	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7301	7301	A	T	MI.4869	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1398	466	M	I	atA/atT	7.44	1	0	benign	0	neutral	1	neutral	3.12	neutral	0.06	neutral	0.05	neutral_impact	-0.72	0.73	neutral	0.98	neutral	-1.10	0.01	neutral	0.48	0.55	0.2	neutral	0.54	disease	0.33	neutral	0.43	neutral	1	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	1.86	high_impact	-1.76	low_impact	0.54	0.9	14.62	41.08	0.51	N	0.00	disease_causing	0.64	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8755	8755	A	T	MI.487	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	229	77	I	F	Att/Ttt	-2.65	0	0	benign	0.35	neutral	0.36	neutral	4.28	neutral	0.77	neutral	-2.38	neutral_impact	0.46	0.91	neutral	0.62	neutral	1.88	15.49	deleterious	0.29	0.65	0.3	neutral	0.56	disease	0.4	neutral	0.46	neutral	1	0.57	neutral	0.51	deleterious	-6	neutral	0.33	neutral	-0.5	medium_impact	0.15	medium_impact	-0.7	medium_impact	0.59	0.9	27.43	20.89	0.32	N	0.43	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7302	7302	T	G	MI.4870	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1399	467	L	V	Tta/Gta	-2.48	0	0	probably_damaging	0.94	deleterious	0.02	neutral	2.84	neutral	-1.1	neutral	-0.3	medium_impact	2.31	0.71	neutral	0.9	neutral	2.27	18.00	deleterious	0.35	0.55	0.21	neutral	0.48	neutral	0.28	neutral	0.44	neutral	1	1	deleterious	0.04	neutral	5	deleterious	0.61	deleterious	-1.88	low_impact	-0.75	medium_impact	1.03	medium_impact	0.57	0.9	9.16	29.82	0.48	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7302	7302	T	A	MI.4871	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1399	467	L	M	Tta/Ata	-2.48	0	0	probably_damaging	1	neutral	0.98	neutral	2.77	neutral	1.04	neutral	0.17	neutral_impact	-0.1	0.68	neutral	0.72	neutral	0.99	10.62	neutral	0.26	0.55	0.42	neutral	0.16	neutral	0.25	neutral	0.29	neutral	4	1	deleterious	0.49	deleterious	-2	neutral	0.64	deleterious	-3.58	low_impact	1.13	medium_impact	-1.19	low_impact	0.63	0.9	9.16	29.82	0.28	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7303	7303	T	G	MI.4872	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1400	467	L	W	tTa/tGa	-1.78	0	0	probably_damaging	1	neutral	0.1	neutral	2.68	deleterious	-3.8	neutral	-0.5	medium_impact	2.86	0.59	damaging	0.13	damaging	2.76	21.20	deleterious	0.14	0.55	0.79	disease	0.75	disease	0.37	neutral	0.66	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.34	medium_impact	1.54	medium_impact	0.56	0.9	9.16	29.82	0.34	N	0.68	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7303	7303	T	C	MI.4873	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1400	467	L	S	tTa/tCa	-1.78	0	0	probably_damaging	1	deleterious	0.01	neutral	2.71	neutral	-2.5	neutral	-0.87	medium_impact	3	0.58	damaging	0.18	damaging	3.85	23.40	deleterious	0.23	0.55	0.48	neutral	0.65	disease	0.55	disease	0.69	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.71	deleterious	-3.58	low_impact	-0.92	medium_impact	1.67	medium_impact	0.70	0.9	9.16	29.82	0.33	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7304	7304	A	C	MI.4874	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1401	467	L	F	ttA/ttC	7.44	0.98	0	probably_damaging	0.99	neutral	0.59	neutral	2.77	neutral	0.22	neutral	0.18	neutral_impact	0.77	0.66	neutral	0.3	neutral	1.35	12.51	neutral	0.38	0.55	0.33	neutral	0.3	neutral	0.23	neutral	0.46	neutral	1	0.99	deleterious	0.3	neutral	-2	neutral	0.66	deleterious	-2.64	low_impact	0.28	medium_impact	-0.39	medium_impact	0.59	0.9	9.16	29.82	0.54	P	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7304	7304	A	T	MI.4875	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1401	467	L	F	ttA/ttT	7.44	0.98	0	probably_damaging	0.99	neutral	0.59	neutral	2.77	neutral	0.22	neutral	0.18	neutral_impact	0.77	0.66	neutral	0.3	neutral	1.46	13.09	neutral	0.38	0.55	0.33	neutral	0.3	neutral	0.23	neutral	0.46	neutral	1	0.99	deleterious	0.3	neutral	-2	neutral	0.66	deleterious	-2.64	low_impact	0.28	medium_impact	-0.39	medium_impact	0.59	0.9	9.16	29.82	0.54	P	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7305	7305	A	G	MI.4876	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1402	468	M	V	Ata/Gta	-3.4	0	0	benign	0.01	deleterious	0	neutral	2.96	neutral	-0.16	neutral	-0.44	medium_impact	3.34	0.74	neutral	0.16	damaging	2.66	20.60	deleterious	0.42	0.55	0.22	neutral	0.85	disease	0.52	disease	0.73	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.18	neutral	1.12	medium_impact	-1.48	low_impact	1.99	medium_impact	0.36	0.9	3.51	7.7	0.36	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7305	7305	A	C	MI.4877	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1402	468	M	L	Ata/Cta	-3.4	0	0	benign	0	neutral	0.2	neutral	3.11	neutral	1.73	neutral	0.08	neutral_impact	-0.4	0.67	neutral	0.31	neutral	1.73	14.57	neutral	0.37	0.55	0.19	neutral	0.69	disease	0.39	neutral	0.5	disease	0	0.8	neutral	0.6	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	-0.14	medium_impact	-1.47	low_impact	0.32	0.9	3.51	7.7	0.39	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	0.45	A7305C	Prostate Cancer	+	-	Reported	1	.	P	P	neutral
chrM	7305	7305	A	T	MI.4878	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1402	468	M	L	Ata/Tta	-3.4	0	0	benign	0	neutral	0.2	neutral	3.11	neutral	1.73	neutral	0.08	neutral_impact	-0.4	0.67	neutral	0.31	neutral	1.80	14.96	neutral	0.37	0.55	0.19	neutral	0.69	disease	0.39	neutral	0.5	disease	0	0.8	neutral	0.6	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	-0.14	medium_impact	-1.47	low_impact	0.32	0.9	3.51	7.7	0.4	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7306	7306	T	C	MI.4879	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1403	468	M	T	aTa/aCa	2.37	0.98	0	benign	0.09	deleterious	0	neutral	2.94	neutral	-1.82	neutral	-0.94	medium_impact	3.34	0.67	neutral	0.14	damaging	3.08	22.50	deleterious	0.4	0.55	0.31	neutral	0.78	disease	0.58	disease	0.76	disease	5	1	deleterious	0.46	neutral	1	deleterious	0.25	neutral	0.19	medium_impact	-1.48	low_impact	1.99	medium_impact	0.34	0.9	3.51	7.7	0.49	N	0.80	polymorphism	0.84	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8756	8756	T	C	MI.488	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	230	77	I	T	aTt/aCt	-4.96	0	0.01	benign	0	neutral	0.25	neutral	4.32	neutral	-0.72	neutral	-2.17	low_impact	0.85	0.96	neutral	0.81	neutral	-0.18	1.22	neutral	0.29	0.65	0.28	neutral	0.25	neutral	0.38	neutral	0.42	neutral	2	0.75	neutral	0.63	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	0.02	medium_impact	-0.37	medium_impact	0.70	0.9	27.43	20.89	0.42	N	0.08	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7306	7306	T	A	MI.4880	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1403	468	M	K	aTa/aAa	2.37	0.98	0	benign	0.06	deleterious	0	neutral	2.91	neutral	-2.93	neutral	-1.24	medium_impact	3.34	0.64	neutral	0.07	damaging	4.14	23.80	deleterious	0.22	0.55	0.16	neutral	0.93	disease	0.66	disease	0.84	disease	7	1	deleterious	0.47	deleterious	1	deleterious	0.27	neutral	0.37	medium_impact	-1.48	low_impact	1.99	medium_impact	0.49	0.9	3.51	7.7	0.43	N	0.93	disease_causing	0.58	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7307	7307	A	T	MI.4881	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1404	468	M	I	atA/atT	7.44	1	0	benign	0.01	deleterious	0.02	neutral	2.95	neutral	0.26	neutral	-0.15	medium_impact	2.29	0.68	neutral	0.18	damaging	3.35	22.90	deleterious	0.41	0.55	0.25	neutral	0.9	disease	0.5	neutral	0.72	disease	4	0.98	neutral	0.51	deleterious	1	deleterious	0.22	neutral	1.12	medium_impact	-0.75	medium_impact	1.02	medium_impact	0.54	0.9	3.51	7.7	0.51	P	0.85	disease_causing	0.59	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7307	7307	A	C	MI.4882	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1404	468	M	I	atA/atC	7.44	1	0	benign	0.01	deleterious	0.02	neutral	2.95	neutral	0.26	neutral	-0.15	medium_impact	2.29	0.68	neutral	0.18	damaging	3.29	22.80	deleterious	0.41	0.55	0.25	neutral	0.9	disease	0.5	neutral	0.72	disease	4	0.98	neutral	0.51	deleterious	1	deleterious	0.22	neutral	1.12	medium_impact	-0.75	medium_impact	1.02	medium_impact	0.54	0.9	3.51	7.7	0.51	P	0.85	disease_causing	0.59	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7308	7308	A	C	MI.4883	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1405	469	I	L	Att/Ctt	0.52	0.21	0	benign	0	neutral	1	neutral	3.02	neutral	0.03	neutral	-0.18	neutral_impact	-0.3	0.73	neutral	0.86	neutral	-0.11	1.63	neutral	0.36	0.55	0.17	neutral	0.3	neutral	0.23	neutral	0.45	neutral	1	0	neutral	1	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	1.86	high_impact	-1.38	low_impact	0.66	0.9	9.16	11.34	0.27	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7308	7308	A	T	MI.4884	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1405	469	I	F	Att/Ttt	0.52	0.21	0	benign	0.07	neutral	0.08	neutral	2.86	deleterious	-3.85	neutral	-0.79	low_impact	1.5	0.69	neutral	0.71	neutral	0.92	10.20	neutral	0.35	0.55	0.21	neutral	0.6	disease	0.34	neutral	0.44	neutral	1	0.91	neutral	0.51	deleterious	-6	neutral	0.16	neutral	0.3	medium_impact	-0.4	medium_impact	0.29	medium_impact	0.71	0.9	9.16	11.34	0.46	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7308	7308	A	G	MI.4885	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1405	469	I	V	Att/Gtt	0.52	0.21	0	benign	0	neutral	0.32	neutral	3.02	neutral	-2.16	neutral	-0.22	low_impact	0.94	0.85	neutral	1	neutral	-0.02	2.39	deleterious	0.55	0.6	0.19	neutral	0.29	neutral	0.36	neutral	0.43	neutral	1	0.68	neutral	0.66	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.01	medium_impact	-0.23	medium_impact	0.41	0.9	9.16	11.34	0.42	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7309	7309	T	A	MI.4886	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1406	469	I	N	aTt/aAt	-0.63	0	0	benign	0.18	neutral	0.09	neutral	2.77	deleterious	-6.38	neutral	-1.81	medium_impact	3.34	0.64	neutral	0.43	neutral	2.94	22.00	deleterious	0.27	0.55	0.56	disease	0.76	disease	0.61	disease	0.72	disease	4	0.9	neutral	0.46	neutral	-3	neutral	0.32	neutral	-0.14	medium_impact	-0.37	medium_impact	1.99	medium_impact	0.63	0.9	9.16	11.34	0.4	N	0.75	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7309	7309	T	G	MI.4887	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1406	469	I	S	aTt/aGt	-0.63	0	0	benign	0.02	neutral	0.07	neutral	2.78	deleterious	-5.31	neutral	-1.47	medium_impact	2.99	0.68	neutral	0.5	neutral	2.49	19.43	deleterious	0.3	0.55	0.38	neutral	0.74	disease	0.58	disease	0.69	disease	4	0.93	neutral	0.53	deleterious	-3	neutral	0.17	neutral	0.83	medium_impact	-0.43	medium_impact	1.66	medium_impact	0.59	0.9	9.16	11.34	0.42	N	0.63	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7309	7309	T	C	MI.4888	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1406	469	I	T	aTt/aCt	-0.63	0	0	benign	0.02	deleterious	0.01	neutral	2.81	deleterious	-4.52	neutral	-1.21	medium_impact	2.79	0.78	neutral	0.91	neutral	0.58	8.02	deleterious	0.45	0.55	0.27	neutral	0.52	disease	0.51	disease	0.52	disease	0	0.99	deleterious	0.5	deleterious	1	deleterious	0.15	neutral	0.83	medium_impact	-0.92	medium_impact	1.48	medium_impact	0.61	0.9	9.16	11.34	0.42	N	0.74	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7310	7310	T	A	MI.4889	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1407	469	I	M	atT/atA	4.67	0.7	0.01	benign	0	neutral	0.34	neutral	2.8	neutral	-2.82	neutral	-0.28	neutral_impact	-0.02	0.69	neutral	0.86	neutral	0.53	7.68	deleterious	0.39	0.55	0.3	neutral	0.28	neutral	0.3	neutral	0.44	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.03	medium_impact	-1.12	low_impact	0.70	0.9	9.16	11.34	0.49	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8756	8756	T	A	MI.489	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	230	77	I	N	aTt/aAt	-4.96	0	0.01	benign	0.17	deleterious	0.02	neutral	4.25	deleterious	-3.31	deleterious	-4.37	low_impact	1.53	0.86	neutral	0.45	neutral	2.42	18.98	deleterious	0.2	0.65	0.79	disease	0.65	disease	0.51	disease	0.57	disease	1	0.98	neutral	0.43	neutral	-2	neutral	0.34	neutral	-0.1	medium_impact	-0.66	medium_impact	0.21	medium_impact	0.64	0.9	27.43	20.89	0.36	N	0.58	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7310	7310	T	G	MI.4890	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1407	469	I	M	atT/atG	4.67	0.7	0.01	benign	0	neutral	0.34	neutral	2.8	neutral	-2.82	neutral	-0.28	neutral_impact	-0.02	0.69	neutral	0.86	neutral	0.16	4.28	deleterious	0.39	0.55	0.3	neutral	0.28	neutral	0.3	neutral	0.44	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.03	medium_impact	-1.12	low_impact	0.70	0.9	9.16	11.34	0.48	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7311	7311	T	C	MI.4891	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1408	470	F	L	Ttc/Ctc	-8.93	0	0	benign	0.04	neutral	0.07	neutral	2.98	neutral	-1.41	neutral	-1.04	medium_impact	3.13	0.68	neutral	0.68	neutral	1.09	11.13	neutral	0.4	0.55	0.25	neutral	0.79	disease	0.4	neutral	0.53	disease	1	0.93	neutral	0.52	deleterious	-3	neutral	0.16	neutral	0.54	medium_impact	-0.43	medium_impact	1.79	medium_impact	0.52	0.9	11.5	53.78	0.48	N	0.63	polymorphism	0.92	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7311	7311	T	A	MI.4892	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1408	470	F	I	Ttc/Atc	-8.93	0	0	benign	0.06	neutral	0.09	neutral	2.98	neutral	-2.23	neutral	-0.99	medium_impact	2.68	0.66	neutral	0.71	neutral	1.23	11.88	neutral	0.25	0.55	0.37	neutral	0.82	disease	0.38	neutral	0.53	disease	1	0.9	neutral	0.52	deleterious	-3	neutral	0.25	neutral	0.37	medium_impact	-0.37	medium_impact	1.38	medium_impact	0.55	0.9	11.5	53.78	0.44	N	0.58	polymorphism	0.93	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7311	7311	T	G	MI.4893	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1408	470	F	V	Ttc/Gtc	-8.93	0	0	benign	0.08	deleterious	0.03	neutral	2.94	neutral	-2.29	neutral	-1.19	medium_impact	3.27	0.64	neutral	0.68	neutral	1.14	11.44	neutral	0.28	0.55	0.31	neutral	0.85	disease	0.4	neutral	0.53	disease	1	0.97	neutral	0.48	deleterious	1	deleterious	0.23	neutral	0.24	medium_impact	-0.65	medium_impact	1.92	medium_impact	0.57	0.9	11.5	53.78	0.44	N	0.73	polymorphism	0.86	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7312	7312	T	A	MI.4894	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1409	470	F	Y	tTc/tAc	7.44	1	0	benign	0	neutral	0.34	neutral	3.02	deleterious	-3.05	neutral	-0.36	low_impact	1.65	0.73	neutral	0.81	neutral	1.01	10.74	neutral	0.33	0.55	0.17	neutral	0.55	disease	0.3	neutral	0.42	neutral	2	0.66	neutral	0.67	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.03	medium_impact	0.43	medium_impact	0.64	0.9	11.5	53.78	0.62	P	0.13	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7312	7312	T	G	MI.4895	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1409	470	F	C	tTc/tGc	7.44	1	0	possibly_damaging	0.69	deleterious	0	neutral	2.82	deleterious	-4.74	neutral	-1.62	high_impact	4	0.68	neutral	0.47	neutral	3.96	23.60	deleterious	0.24	0.55	0.81	disease	0.89	disease	0.54	disease	0.73	disease	5	1	deleterious	0.16	neutral	5	deleterious	0.67	deleterious	-1.08	low_impact	-1.48	low_impact	2.59	high_impact	0.36	0.9	11.5	53.78	0.5	P	0.78	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7312	7312	T	C	MI.4896	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1409	470	F	S	tTc/tCc	7.44	1	0	benign	0	deleterious	0	neutral	2.86	deleterious	-3.44	neutral	-1.74	high_impact	4	0.71	neutral	0.49	neutral	2.61	20.20	deleterious	0.36	0.55	0.66	disease	0.86	disease	0.53	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.24	neutral	2.07	high_impact	-1.48	low_impact	2.59	high_impact	0.58	0.9	11.5	53.78	0.56	P	0.83	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7313	7313	C	G	MI.4897	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1410	470	F	L	ttC/ttG	4.67	1	0	benign	0.04	neutral	0.07	neutral	2.98	neutral	-1.41	neutral	-1.04	medium_impact	3.13	0.68	neutral	0.68	neutral	1.37	12.61	neutral	0.4	0.55	0.25	neutral	0.79	disease	0.4	neutral	0.53	disease	1	0.93	neutral	0.52	deleterious	-3	neutral	0.16	neutral	0.54	medium_impact	-0.43	medium_impact	1.79	medium_impact	0.52	0.9	11.5	53.78	0.61	P	0.63	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7313	7313	C	A	MI.4898	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1410	470	F	L	ttC/ttA	4.67	1	0	benign	0.04	neutral	0.07	neutral	2.98	neutral	-1.41	neutral	-1.04	medium_impact	3.13	0.68	neutral	0.68	neutral	1.70	14.40	neutral	0.4	0.55	0.25	neutral	0.79	disease	0.4	neutral	0.53	disease	1	0.93	neutral	0.52	deleterious	-3	neutral	0.16	neutral	0.54	medium_impact	-0.43	medium_impact	1.79	medium_impact	0.52	0.9	11.5	53.78	0.61	P	0.63	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7314	7314	A	C	MI.4899	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1411	471	M	L	Atg/Ctg	-4.09	0	0	possibly_damaging	0.7	neutral	0.19	neutral	3.11	neutral	2.08	neutral	0.26	neutral_impact	0.6	0.66	neutral	0.7	neutral	2.28	18.05	deleterious	0.47	0.55	0.23	neutral	0.71	disease	0.36	neutral	0.53	disease	1	0.85	neutral	0.25	neutral	-3	neutral	0.49	deleterious	-1.1	low_impact	-0.16	medium_impact	-0.55	medium_impact	0.54	0.9	5.65	41.36	0.42	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8548	8548	T	A	MI.49	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	22	8	S	T	Tca/Aca	-0.1	0.83	0	benign	0.08	neutral	1	neutral	4.67	neutral	-0.68	neutral	-1.31	low_impact	1.16	0.9	neutral	0.59	neutral	1.67	14.23	neutral	0.33	0.65	0.41	neutral	0.38	neutral	0.28	neutral	0.44	neutral	1	0.08	neutral	0.96	deleterious	-6	neutral	0.26	neutral	0.25	medium_impact	1.98	high_impact	-0.1	medium_impact	0.65	0.9	21.24	17.86	0.27	N	0.33	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8756	8756	T	G	MI.490	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	230	77	I	S	aTt/aGt	-4.96	0	0.01	benign	0.07	neutral	0.33	neutral	4.28	neutral	-1.53	deleterious	-3.41	low_impact	1.06	0.9	neutral	0.67	neutral	2.18	17.37	deleterious	0.24	0.65	0.51	disease	0.53	disease	0.56	disease	0.49	neutral	0	0.64	neutral	0.63	deleterious	-6	neutral	0.21	neutral	0.31	medium_impact	0.12	medium_impact	-0.19	medium_impact	0.61	0.9	27.43	20.89	0.34	N	0.41	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7314	7314	A	T	MI.4900	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1411	471	M	L	Atg/Ttg	-4.09	0	0	possibly_damaging	0.7	neutral	0.19	neutral	3.11	neutral	2.08	neutral	0.26	neutral_impact	0.6	0.66	neutral	0.7	neutral	2.26	17.89	deleterious	0.47	0.55	0.23	neutral	0.71	disease	0.36	neutral	0.53	disease	1	0.85	neutral	0.25	neutral	-3	neutral	0.49	deleterious	-1.1	low_impact	-0.16	medium_impact	-0.55	medium_impact	0.54	0.9	5.65	41.36	0.42	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7314	7314	A	G	MI.4901	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1411	471	M	V	Atg/Gtg	-4.09	0	0	possibly_damaging	0.79	neutral	0.16	neutral	3.07	neutral	2.7	neutral	0.53	low_impact	1.65	0.65	neutral	0.59	neutral	2.70	20.80	deleterious	0.55	0.6	0.17	neutral	0.72	disease	0.36	neutral	0.53	disease	1	0.9	neutral	0.19	neutral	-3	neutral	0.53	deleterious	-1.3	low_impact	-0.21	medium_impact	0.43	medium_impact	0.58	0.9	5.65	41.36	0.43	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7315	7315	T	C	MI.4902	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1412	471	M	T	aTg/aCg	6.75	1	0	possibly_damaging	0.9	deleterious	0.02	neutral	3.01	neutral	-0.15	neutral	-0.63	low_impact	0.93	0.73	neutral	0.75	neutral	3.04	22.40	deleterious	0.44	0.55	0.24	neutral	0.69	disease	0.58	disease	0.55	disease	1	0.99	deleterious	0.06	neutral	1	deleterious	0.67	deleterious	-1.65	low_impact	-0.75	medium_impact	-0.24	medium_impact	0.43	0.9	5.65	41.36	0.45	N	0.56	disease_causing	0.92	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7315	7315	T	A	MI.4903	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1412	471	M	K	aTg/aAg	6.75	1	0	possibly_damaging	0.9	deleterious	0	neutral	2.99	neutral	-1.46	neutral	-1.27	medium_impact	2.46	0.54	damaging	0.36	neutral	4.22	23.90	deleterious	0.23	0.55	0.21	neutral	0.91	disease	0.67	disease	0.83	disease	7	1	deleterious	0.05	neutral	4	deleterious	0.73	deleterious	-1.65	low_impact	-1.48	low_impact	1.17	medium_impact	0.61	0.9	5.65	41.36	0.5	P	0.74	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7316	7316	G	T	MI.4904	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1413	471	M	I	atG/atT	7.44	1	0	possibly_damaging	0.84	neutral	1	neutral	3.23	neutral	6.69	neutral	0.83	neutral_impact	-2.16	0.77	neutral	0.98	neutral	1.01	10.74	neutral	0.45	0.55	0.15	neutral	0.3	neutral	0.29	neutral	0.43	neutral	2	0.84	neutral	0.58	deleterious	-3	neutral	0.55	deleterious	-1.43	low_impact	1.86	high_impact	-3.09	low_impact	0.57	0.9	5.65	41.36	0.5	N	0.01	disease_causing	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7316	7316	G	C	MI.4905	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1413	471	M	I	atG/atC	7.44	1	0	possibly_damaging	0.84	neutral	1	neutral	3.23	neutral	6.69	neutral	0.83	neutral_impact	-2.16	0.77	neutral	0.98	neutral	0.89	10.05	neutral	0.45	0.55	0.15	neutral	0.3	neutral	0.29	neutral	0.43	neutral	2	0.84	neutral	0.58	deleterious	-3	neutral	0.55	deleterious	-1.43	low_impact	1.86	high_impact	-3.09	low_impact	0.57	0.9	5.65	41.36	0.5	N	0.01	disease_causing	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7317	7317	A	C	MI.4906	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1414	472	I	L	Att/Ctt	-3.4	0	0	benign	0.03	neutral	0.77	neutral	3.02	neutral	-1.83	neutral	-0.23	low_impact	1.17	0.65	neutral	0.72	neutral	-0.23	0.93	neutral	0.38	0.55	0.35	neutral	0.35	neutral	0.21	neutral	0.47	neutral	1	0.17	neutral	0.87	deleterious	-6	neutral	0.12	neutral	0.66	medium_impact	0.48	medium_impact	-0.02	medium_impact	0.78	0.9	11.11	14.52	0.36	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7317	7317	A	T	MI.4907	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1414	472	I	F	Att/Ttt	-3.4	0	0	benign	0.36	deleterious	0.01	neutral	2.84	deleterious	-5.75	neutral	-1.03	medium_impact	2.75	0.62	neutral	0.46	neutral	2.13	17.03	deleterious	0.38	0.55	0.76	disease	0.75	disease	0.39	neutral	0.6	disease	2	0.99	deleterious	0.33	neutral	1	deleterious	0.45	deleterious	-0.52	medium_impact	-0.92	medium_impact	1.44	medium_impact	0.80	0.9	11.11	14.52	0.37	N	0.85	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7317	7317	A	G	MI.4908	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1414	472	I	V	Att/Gtt	-3.4	0	0	benign	0.01	neutral	0.33	neutral	2.98	deleterious	-3.66	neutral	-0.24	low_impact	1.58	0.81	neutral	0.98	neutral	-0.57	0.15	neutral	0.67	0.7	0.23	neutral	0.23	neutral	0.27	neutral	0.44	neutral	1	0.66	neutral	0.66	deleterious	-6	neutral	0.08	neutral	1.12	medium_impact	0.02	medium_impact	0.36	medium_impact	0.61	0.9	11.11	14.52	0.46	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7318	7318	T	A	MI.4909	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1415	472	I	N	aTt/aAt	-0.63	0	0.01	benign	0.32	deleterious	0	neutral	2.74	deleterious	-7.17	neutral	-1.99	high_impact	3.99	0.65	neutral	0.39	neutral	4.39	24.10	deleterious	0.29	0.55	0.91	disease	0.84	disease	0.61	disease	0.8	disease	6	1	deleterious	0.34	neutral	2	deleterious	0.56	deleterious	-0.45	medium_impact	-1.48	low_impact	2.59	high_impact	0.69	0.9	11.11	14.52	0.35	N	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8757	8757	T	G	MI.491	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	231	77	I	M	atT/atG	1.52	0	0	possibly_damaging	0.54	neutral	0.32	neutral	4.36	neutral	-0.61	neutral	-0.76	neutral_impact	-0.4	0.9	neutral	0.94	neutral	1.34	12.48	neutral	0.31	0.65	0.38	neutral	0.16	neutral	0.31	neutral	0.29	neutral	4	0.67	neutral	0.39	neutral	-3	neutral	0.45	deleterious	-0.82	medium_impact	0.11	medium_impact	-1.44	low_impact	0.72	0.9	27.43	20.89	0.47	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7318	7318	T	G	MI.4910	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1415	472	I	S	aTt/aGt	-0.63	0	0.01	benign	0.14	deleterious	0	neutral	2.76	deleterious	-6.04	neutral	-1.66	high_impact	3.99	0.65	neutral	0.41	neutral	2.81	21.40	deleterious	0.39	0.55	0.83	disease	0.82	disease	0.59	disease	0.77	disease	5	1	deleterious	0.43	neutral	2	deleterious	0.34	neutral	-0.01	medium_impact	-1.48	low_impact	2.59	high_impact	0.63	0.9	11.11	14.52	0.38	N	0.65	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7318	7318	T	C	MI.4911	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1415	472	I	T	aTt/aCt	-0.63	0	0.01	benign	0.01	deleterious	0.01	neutral	2.79	deleterious	-5.55	neutral	-1.32	high_impact	3.54	0.69	neutral	0.59	neutral	1.75	14.71	neutral	0.47	0.55	0.74	disease	0.63	disease	0.51	disease	0.55	disease	1	0.99	deleterious	0.5	deleterious	2	deleterious	0.23	neutral	1.12	medium_impact	-0.92	medium_impact	2.17	high_impact	0.78	0.9	11.11	14.52	0.41	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7319	7319	T	A	MI.4912	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1416	472	I	M	atT/atA	5.83	0.89	0	possibly_damaging	0.55	neutral	0.06	neutral	2.8	deleterious	-5.11	neutral	-0.51	medium_impact	2.34	0.72	neutral	0.71	neutral	0.76	9.24	deleterious	0.44	0.55	0.44	neutral	0.43	neutral	0.29	neutral	0.48	neutral	0	0.94	neutral	0.26	neutral	0	NA	0.37	neutral	-0.84	medium_impact	-0.47	medium_impact	1.06	medium_impact	0.83	0.9	11.11	14.52	0.55	P	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7319	7319	T	G	MI.4913	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1416	472	I	M	atT/atG	5.83	0.89	0	possibly_damaging	0.55	neutral	0.06	neutral	2.8	deleterious	-5.11	neutral	-0.51	medium_impact	2.34	0.72	neutral	0.71	neutral	0.59	8.11	deleterious	0.44	0.55	0.44	neutral	0.43	neutral	0.29	neutral	0.48	neutral	0	0.94	neutral	0.26	neutral	0	NA	0.37	neutral	-0.84	medium_impact	-0.47	medium_impact	1.06	medium_impact	0.83	0.9	11.11	14.52	0.55	P	0.73	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7320	7320	T	C	MI.4914	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1417	473	W	R	Tga/Cga	-6.86	0	0	probably_damaging	1	deleterious	0	neutral	2.82	deleterious	-9.03	deleterious	-4.48	high_impact	4.69	0.61	neutral	0.04	damaging	3.69	23.30	deleterious	0.44	0.55	0.57	disease	0.95	disease	0.74	disease	0.89	disease	8	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.58	low_impact	-1.48	low_impact	3.23	high_impact	0.32	0.9	NA	NA	0.48	N	0.94	polymorphism	0.99	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7320	7320	T	G	MI.4915	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1417	473	W	G	Tga/Gga	-6.86	0	0	probably_damaging	0.99	deleterious	0	neutral	2.82	deleterious	-9.07	deleterious	-4.17	high_impact	4.34	0.65	neutral	0.06	damaging	4.01	23.60	deleterious	0.32	0.55	0.58	disease	0.93	disease	0.7	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.64	low_impact	-1.48	low_impact	2.91	high_impact	0.34	0.9	NA	NA	0.29	N	0.90	polymorphism	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7321	7321	G	T	MI.4916	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1418	473	W	L	tGa/tTa	7.44	1	0	probably_damaging	0.99	neutral	0.18	neutral	3.01	deleterious	-7.72	deleterious	-4.12	medium_impact	2.96	0.67	neutral	0.04	damaging	4.31	24.00	deleterious	0.27	0.55	0.2	neutral	0.87	disease	0.55	disease	0.52	disease	0	1	deleterious	0.1	neutral	1	deleterious	0.76	deleterious	-2.64	low_impact	-0.17	medium_impact	1.63	medium_impact	0.31	0.9	NA	NA	0.39	N	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7321	7321	G	C	MI.4917	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1418	473	W	S	tGa/tCa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.82	deleterious	-8.7	deleterious	-4.47	high_impact	4.34	0.63	neutral	0.05	damaging	4.12	23.80	deleterious	0.3	0.55	0.43	neutral	0.94	disease	0.68	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-1.48	low_impact	2.91	high_impact	0.32	0.9	NA	NA	0.38	N	0.88	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7322	7322	A	T	MI.4918	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1419	473	W	C	tgA/tgT	9.29	1	0	probably_damaging	1	deleterious	0.01	neutral	2.8	deleterious	-10.44	deleterious	-4.16	high_impact	4.69	0.54	damaging	0.05	damaging	4.29	24.00	deleterious	0.33	0.55	0.63	disease	0.93	disease	0.66	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.92	medium_impact	3.23	high_impact	0.28	0.9	NA	NA	0.47	P	0.88	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7322	7322	A	C	MI.4919	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1419	473	W	C	tgA/tgC	9.29	1	0	probably_damaging	1	deleterious	0.01	neutral	2.8	deleterious	-10.44	deleterious	-4.16	high_impact	4.69	0.54	damaging	0.05	damaging	4.17	23.80	deleterious	0.33	0.55	0.63	disease	0.93	disease	0.66	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.92	medium_impact	3.23	high_impact	0.28	0.9	NA	NA	0.47	P	0.88	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8757	8757	T	A	MI.492	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	231	77	I	M	atT/atA	1.52	0	0	possibly_damaging	0.54	neutral	0.32	neutral	4.36	neutral	-0.61	neutral	-0.76	neutral_impact	-0.4	0.9	neutral	0.94	neutral	1.68	14.29	neutral	0.31	0.65	0.38	neutral	0.16	neutral	0.31	neutral	0.29	neutral	4	0.67	neutral	0.39	neutral	-3	neutral	0.45	deleterious	-0.82	medium_impact	0.11	medium_impact	-1.44	low_impact	0.72	0.9	27.43	20.89	0.48	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7323	7323	G	C	MI.4920	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1420	474	E	Q	Gaa/Caa	2.14	1	0	probably_damaging	0.99	deleterious	0	neutral	2.83	deleterious	-4.26	neutral	-0.91	high_impact	4.76	0.56	damaging	0.16	damaging	3.56	23.10	deleterious	0.38	0.55	0.27	neutral	0.83	disease	0.59	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-1.48	low_impact	3.3	high_impact	0.78	0.9	2.73	6.62	0.63	P	0.66	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7323	7323	G	A	MI.4921	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1420	474	E	K	Gaa/Aaa	2.14	1	0	probably_damaging	1	deleterious	0	neutral	2.89	deleterious	-3.34	neutral	-1.19	high_impact	3.61	0.46	damaging	0.1	damaging	4.64	24.50	deleterious	0.26	0.55	0.2	neutral	0.93	disease	0.41	neutral	0.52	disease	0	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.63	0.9	2.73	6.62	0.51	N	0.72	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7324	7324	A	T	MI.4922	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1421	474	E	V	gAa/gTa	9.29	1	0	probably_damaging	1	deleterious	0	neutral	2.94	deleterious	-5.71	neutral	-2.19	high_impact	4.76	0.49	damaging	0.14	damaging	4.21	23.90	deleterious	0.19	0.55	0.48	neutral	0.94	disease	0.63	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.68	0.9	2.73	6.62	0.65	P	0.68	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7324	7324	A	G	MI.4923	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1421	474	E	G	gAa/gGa	9.29	1	0	probably_damaging	1	deleterious	0	neutral	2.83	deleterious	-5.18	neutral	-2.13	high_impact	4.42	0.44	damaging	0.19	damaging	4.35	24.10	deleterious	0.24	0.55	0.45	neutral	0.89	disease	0.62	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.55	0.9	2.73	6.62	0.6	P	0.67	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7324	7324	A	C	MI.4924	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1421	474	E	A	gAa/gCa	9.29	1	0	probably_damaging	1	deleterious	0	neutral	2.88	deleterious	-4.41	neutral	-1.86	high_impact	4.76	0.6	damaging	0.16	damaging	3.71	23.30	deleterious	0.16	0.55	0.3	neutral	0.84	disease	0.6	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.73	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.54	0.9	2.73	6.62	0.65	P	0.70	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7325	7325	A	C	MI.4925	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1422	474	E	D	gaA/gaC	6.98	1	0	probably_damaging	0.94	neutral	0.1	neutral	2.83	deleterious	-3.84	neutral	-0.84	medium_impact	3.48	0.5	damaging	0.16	damaging	3.77	23.40	deleterious	0.32	0.55	0.22	neutral	0.77	disease	0.25	neutral	0.48	neutral	0	0.98	neutral	0.08	neutral	1	deleterious	0.68	deleterious	-1.88	low_impact	-0.34	medium_impact	2.11	high_impact	0.74	0.9	2.73	6.62	0.57	P	0.70	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7325	7325	A	T	MI.4926	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1422	474	E	D	gaA/gaT	6.98	1	0	probably_damaging	0.94	neutral	0.1	neutral	2.83	deleterious	-3.84	neutral	-0.84	medium_impact	3.48	0.5	damaging	0.16	damaging	3.90	23.50	deleterious	0.32	0.55	0.22	neutral	0.77	disease	0.25	neutral	0.48	neutral	0	0.98	neutral	0.08	neutral	1	deleterious	0.68	deleterious	-1.88	low_impact	-0.34	medium_impact	2.11	high_impact	0.74	0.9	2.73	6.62	0.59	P	0.70	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7326	7326	G	C	MI.4927	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1423	475	A	P	Gcc/Ccc	-0.17	0.57	0	probably_damaging	1	deleterious	0.01	neutral	2.88	neutral	-2.3	neutral	-0.94	high_impact	4.32	0.48	damaging	0.07	damaging	4.01	23.60	deleterious	0.11	0.55	0.55	disease	0.94	disease	0.65	disease	0.84	disease	7	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.58	low_impact	-0.92	medium_impact	2.89	high_impact	0.86	0.9	3.9	7.29	0.39	N	0.85	disease_causing	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7326	7326	G	A	MI.4928	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1423	475	A	T	Gcc/Acc	-0.17	0.57	0	probably_damaging	0.99	deleterious	0.01	neutral	3.08	neutral	-0.91	neutral	-0.39	medium_impact	3.07	0.49	damaging	0.06	damaging	3.37	22.90	deleterious	0.38	0.55	0.27	neutral	0.69	disease	0.18	neutral	0.48	neutral	0	1	deleterious	0.01	neutral	5	deleterious	0.71	deleterious	-2.64	low_impact	-0.92	medium_impact	1.74	medium_impact	0.77	0.9	3.9	7.29	0.4	N	0.23	disease_causing	0.95	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7326	7326	G	T	MI.4929	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1423	475	A	S	Gcc/Tcc	-0.17	0.57	0	probably_damaging	0.99	neutral	0.76	neutral	3.15	neutral	3.69	neutral	0.39	low_impact	1.46	0.54	damaging	0.11	damaging	1.55	13.58	neutral	0.39	0.55	0.19	neutral	0.23	neutral	0.14	neutral	0.43	neutral	1	0.99	deleterious	0.39	neutral	-2	neutral	0.64	deleterious	-2.64	low_impact	0.47	medium_impact	0.25	medium_impact	0.79	0.9	3.9	7.29	0.33	N	0.61	disease_causing	0.88	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8758	8758	T	A	MI.493	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	232	78	F	I	Ttt/Att	-8.2	0	0	probably_damaging	0.99	neutral	0.11	neutral	4.13	deleterious	-3.1	deleterious	-5.26	medium_impact	2.48	0.9	neutral	0.2	damaging	4.26	23.90	deleterious	0.24	0.65	0.74	disease	0.82	disease	0.61	disease	0.59	disease	2	0.99	deleterious	0.06	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	-0.22	medium_impact	1.03	medium_impact	0.57	0.9	49.56	8.89	0.37	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7327	7327	C	A	MI.4930	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1424	475	A	D	gCc/gAc	7.21	1	0	probably_damaging	1	deleterious	0	neutral	2.86	neutral	-1.57	neutral	-0.79	high_impact	4.32	0.5	damaging	0.05	damaging	4.84	24.80	deleterious	0.19	0.55	0.5	disease	0.94	disease	0.64	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.58	low_impact	-1.48	low_impact	2.89	high_impact	0.68	0.9	3.9	7.29	0.49	P	0.89	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7327	7327	C	G	MI.4931	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1424	475	A	G	gCc/gGc	7.21	1	0	probably_damaging	0.97	neutral	0.08	neutral	2.91	neutral	-0.62	neutral	-0.51	medium_impact	2.96	0.5	damaging	0.11	damaging	4.08	23.70	deleterious	0.26	0.55	0.37	neutral	0.8	disease	0.21	neutral	0.48	neutral	0	0.99	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-2.18	low_impact	-0.4	medium_impact	1.63	medium_impact	0.84	0.9	3.9	7.29	0.54	P	0.56	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7327	7327	C	T	MI.4932	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1424	475	A	V	gCc/gTc	7.21	1	0	probably_damaging	0.99	deleterious	0	neutral	2.9	neutral	-1.75	neutral	-1.08	high_impact	4.32	0.5	damaging	0.06	damaging	4.58	24.40	deleterious	0.28	0.55	0.27	neutral	0.87	disease	0.51	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.64	low_impact	-1.48	low_impact	2.89	high_impact	0.76	0.9	3.9	7.29	0.49	P	0.75	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7329	7329	T	A	MI.4933	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1426	476	F	I	Ttc/Atc	-7.09	0	0	benign	0.1	neutral	0.12	neutral	3.07	neutral	0.37	neutral	-0.14	medium_impact	2.75	0.66	neutral	0.65	neutral	3.44	23.00	deleterious	0.28	0.55	0.33	neutral	0.87	disease	0.26	neutral	0.49	neutral	0	0.87	neutral	0.51	deleterious	-3	neutral	0.27	neutral	0.14	medium_impact	-0.29	medium_impact	1.44	medium_impact	0.52	0.9	5.07	8.7	0.48	N	0.87	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7329	7329	T	G	MI.4934	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1426	476	F	V	Ttc/Gtc	-7.09	0	0	benign	0.29	neutral	0.07	neutral	3.01	neutral	0.28	neutral	-0.3	high_impact	3.73	0.68	neutral	0.5	neutral	4.29	24.00	deleterious	0.3	0.55	0.27	neutral	0.9	disease	0.31	neutral	0.7	disease	4	0.92	neutral	0.39	neutral	-2	neutral	0.28	neutral	-0.39	medium_impact	-0.43	medium_impact	2.35	high_impact	0.43	0.9	5.07	8.7	0.49	N	0.84	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7329	7329	T	C	MI.4935	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1426	476	F	L	Ttc/Ctc	-7.09	0	0	benign	0	neutral	0.3	neutral	3.18	neutral	1.94	neutral	0.12	low_impact	0.88	0.71	neutral	0.92	neutral	2.27	17.98	deleterious	0.44	0.55	0.16	neutral	0.55	disease	0.16	neutral	0.43	neutral	2	0.7	neutral	0.65	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	-0.01	medium_impact	-0.29	medium_impact	0.44	0.9	5.07	8.7	0.54	N	0.81	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7330	7330	T	A	MI.4936	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1427	476	F	Y	tTc/tAc	5.83	1	0	benign	0.33	neutral	0.05	neutral	2.93	neutral	-1.83	neutral	-0.48	high_impact	3.93	0.67	neutral	0.46	neutral	4.35	24.10	deleterious	0.45	0.55	0.46	neutral	0.82	disease	0.28	neutral	0.52	disease	0	0.94	neutral	0.36	neutral	-2	neutral	0.44	deleterious	-0.47	medium_impact	-0.52	medium_impact	2.53	high_impact	0.64	0.9	5.07	8.7	0.6	P	0.58	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7330	7330	T	G	MI.4937	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1427	476	F	C	tTc/tGc	5.83	1	0	probably_damaging	0.94	neutral	0.05	neutral	2.89	neutral	-2.65	neutral	-0.9	high_impact	4.28	0.68	neutral	0.47	neutral	4.28	24.00	deleterious	0.26	0.55	0.66	disease	0.9	disease	0.46	neutral	0.75	disease	5	0.99	deleterious	0.06	neutral	2	deleterious	0.73	deleterious	-1.88	low_impact	-0.52	medium_impact	2.85	high_impact	0.27	0.9	5.07	8.7	0.57	P	0.91	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7330	7330	T	C	MI.4938	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1427	476	F	S	tTc/tCc	5.83	1	0	possibly_damaging	0.76	deleterious	0	neutral	2.92	neutral	-1.38	neutral	-0.98	high_impact	3.93	0.74	neutral	0.51	neutral	4.38	24.10	deleterious	0.35	0.55	0.29	neutral	0.87	disease	0.59	disease	0.74	disease	5	1	deleterious	0.12	neutral	5	deleterious	0.62	deleterious	-1.23	low_impact	-1.48	low_impact	2.53	high_impact	0.49	0.9	5.07	8.7	0.55	P	0.85	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7331	7331	C	G	MI.4939	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1428	476	F	L	ttC/ttG	7.44	1	0	benign	0	neutral	0.3	neutral	3.18	neutral	1.94	neutral	0.12	low_impact	0.88	0.71	neutral	0.92	neutral	2.56	19.88	deleterious	0.44	0.55	0.16	neutral	0.55	disease	0.16	neutral	0.43	neutral	2	0.7	neutral	0.65	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	-0.01	medium_impact	-0.29	medium_impact	0.44	0.9	5.07	8.7	0.62	P	0.81	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8758	8758	T	C	MI.494	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	232	78	F	L	Ttt/Ctt	-8.2	0	0	probably_damaging	0.98	neutral	0.52	neutral	4.21	neutral	-2.28	deleterious	-5.21	low_impact	1.2	0.84	neutral	0.29	neutral	2.82	21.50	deleterious	0.33	0.65	0.57	disease	0.63	disease	0.47	neutral	0.49	neutral	0	0.98	neutral	0.27	neutral	-2	neutral	0.74	deleterious	-2.36	low_impact	0.31	medium_impact	-0.07	medium_impact	0.55	0.9	49.56	8.89	0.23	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7331	7331	C	A	MI.4940	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1428	476	F	L	ttC/ttA	7.44	1	0	benign	0	neutral	0.3	neutral	3.18	neutral	1.94	neutral	0.12	low_impact	0.88	0.71	neutral	0.92	neutral	2.89	21.80	deleterious	0.44	0.55	0.16	neutral	0.55	disease	0.16	neutral	0.43	neutral	2	0.7	neutral	0.65	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	-0.01	medium_impact	-0.29	medium_impact	0.44	0.9	5.07	8.7	0.62	P	0.81	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7332	7332	G	T	MI.4941	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1429	477	A	S	Gct/Tct	-3.4	0	0	benign	0.01	neutral	0.6	neutral	3	neutral	1.9	neutral	-0.07	neutral_impact	-0.1	0.65	neutral	0.38	neutral	-0.39	0.40	neutral	0.3	0.55	0.25	neutral	0.29	neutral	0.12	neutral	0.44	neutral	1	0.39	neutral	0.8	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	0.29	medium_impact	-1.19	low_impact	0.61	0.9	9.75	25.17	0.41	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7332	7332	G	A	MI.4942	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1429	477	A	T	Gct/Act	-3.4	0	0	benign	0.13	neutral	0.52	neutral	2.98	neutral	-1.06	neutral	0.07	low_impact	0.94	0.65	neutral	0.74	neutral	0.72	8.93	deleterious	0.4	0.55	0.26	neutral	0.3	neutral	0.12	neutral	0.44	neutral	1	0.39	neutral	0.7	deleterious	-6	neutral	0.21	neutral	0.02	medium_impact	0.21	medium_impact	-0.23	medium_impact	0.56	0.9	9.75	25.17	0.48	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7332	7332	G	C	MI.4943	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1429	477	A	P	Gct/Cct	-3.4	0	0	possibly_damaging	0.9	neutral	0.2	neutral	2.94	neutral	-2.75	neutral	-0.7	medium_impact	3.47	0.6	damaging	0.13	damaging	3.81	23.40	deleterious	0.25	0.55	0.55	disease	0.84	disease	0.57	disease	0.8	disease	6	0.93	neutral	0.15	neutral	0	NA	0.71	deleterious	-1.65	low_impact	-0.14	medium_impact	2.11	high_impact	0.64	0.9	9.75	25.17	0.32	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7333	7333	C	G	MI.4944	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1430	477	A	G	gCt/gGt	0.29	0.04	0	benign	0.04	neutral	0.31	neutral	2.96	neutral	-2.14	neutral	-0.8	medium_impact	3.12	0.65	neutral	0.17	damaging	1.18	11.64	neutral	0.3	0.55	0.47	neutral	0.55	disease	0.28	neutral	0.47	neutral	1	0.67	neutral	0.64	deleterious	-3	neutral	0.18	neutral	0.54	medium_impact	0	medium_impact	1.78	medium_impact	0.55	0.9	9.75	25.17	0.43	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7333	7333	C	T	MI.4945	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1430	477	A	V	gCt/gTt	0.29	0.04	0	benign	0.11	neutral	0.62	neutral	3.05	neutral	0.47	neutral	0.29	low_impact	1.44	0.63	neutral	0.23	damaging	0.57	7.94	deleterious	0.35	0.55	0.24	neutral	0.42	neutral	0.12	neutral	0.45	neutral	1	0.28	neutral	0.76	deleterious	-6	neutral	0.38	neutral	0.1	medium_impact	0.31	medium_impact	0.23	medium_impact	0.46	0.9	9.75	25.17	0.38	N	0.75	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7333	7333	C	A	MI.4946	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1430	477	A	D	gCt/gAt	0.29	0.04	0	possibly_damaging	0.74	neutral	0.2	neutral	2.92	neutral	-1.66	neutral	-0.73	medium_impact	3.47	0.62	neutral	0.12	damaging	4.50	24.30	deleterious	0.25	0.55	0.4	neutral	0.81	disease	0.5	neutral	0.7	disease	4	0.85	neutral	0.23	neutral	0	NA	0.46	deleterious	-1.18	low_impact	-0.14	medium_impact	2.11	high_impact	0.48	0.9	9.75	25.17	0.39	N	0.89	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7335	7335	T	C	MI.4947	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1432	478	S	P	Tcg/Ccg	-4.78	0	0	benign	0.38	deleterious	0.02	neutral	2.83	deleterious	-3.53	neutral	-1.07	high_impact	4	0.51	damaging	0.33	neutral	3.75	23.30	deleterious	0.26	0.55	0.28	neutral	0.9	disease	0.64	disease	0.77	disease	5	0.98	neutral	0.32	neutral	2	deleterious	0.62	deleterious	-0.56	medium_impact	-0.75	medium_impact	2.59	high_impact	0.40	0.9	10.92	10.75	0.39	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7335	7335	T	A	MI.4948	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1432	478	S	T	Tcg/Acg	-4.78	0	0	benign	0.03	neutral	0.18	neutral	2.88	neutral	-0.54	neutral	-0.31	medium_impact	2.27	0.67	neutral	0.61	neutral	0.84	9.71	deleterious	0.45	0.55	0.35	neutral	0.49	neutral	0.2	neutral	0.45	neutral	1	0.81	neutral	0.58	deleterious	-3	neutral	0.16	neutral	0.66	medium_impact	-0.17	medium_impact	1	medium_impact	0.81	0.9	10.92	10.75	0.53	P	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7335	7335	T	G	MI.4949	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1432	478	S	A	Tcg/Gcg	-4.78	0	0	benign	0.03	neutral	0.63	neutral	2.91	neutral	-1.74	neutral	-0.56	low_impact	1.39	0.75	neutral	0.86	neutral	0.56	7.89	deleterious	0.43	0.55	0.22	neutral	0.49	neutral	0.37	neutral	0.46	neutral	1	0.32	neutral	0.8	deleterious	-6	neutral	0.14	neutral	0.66	medium_impact	0.32	medium_impact	0.18	medium_impact	0.63	0.9	10.92	10.75	0.32	N	0.33	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8758	8758	T	G	MI.495	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	232	78	F	V	Ttt/Gtt	-8.2	0	0	probably_damaging	0.99	neutral	0.27	neutral	4.22	neutral	-2.89	deleterious	-6.17	medium_impact	2.63	0.84	neutral	0.19	damaging	3.86	23.50	deleterious	0.21	0.65	0.61	disease	0.84	disease	0.67	disease	0.57	disease	1	0.99	deleterious	0.14	neutral	1	deleterious	0.78	deleterious	-2.65	low_impact	0.05	medium_impact	1.16	medium_impact	0.59	0.9	49.56	8.89	0.27	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7336	7336	C	G	MI.4950	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1433	478	S	W	tCg/tGg	3.29	1	0	probably_damaging	0.97	deleterious	0.04	neutral	2.82	deleterious	-5.96	neutral	-1.5	high_impact	4	0.66	neutral	0.41	neutral	4.48	24.20	deleterious	0.24	0.55	0.59	disease	0.92	disease	0.59	disease	0.77	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.78	deleterious	-2.18	low_impact	-0.58	medium_impact	2.59	high_impact	0.45	0.9	10.92	10.75	0.4	N	0.94	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7336	7336	C	T	MI.4951	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1433	478	S	L	tCg/tTg	3.29	1	0	benign	0.04	neutral	0.14	neutral	2.92	neutral	-2.69	neutral	-1.09	medium_impact	3.06	0.68	neutral	0.41	neutral	2.81	21.40	deleterious	0.36	0.55	0.32	neutral	0.81	disease	0.41	neutral	0.55	disease	1	0.85	neutral	0.55	deleterious	-3	neutral	0.20	neutral	0.54	medium_impact	-0.25	medium_impact	1.73	medium_impact	0.78	0.9	10.92	10.75	0.57	P	0.91	disease_causing	0.94	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7338	7338	A	G	MI.4952	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1435	479	K	E	Aag/Gag	-5.47	0	0	probably_damaging	0.99	neutral	0.15	neutral	2.89	deleterious	-3.9	neutral	-0.23	high_impact	3.77	0.53	damaging	0.11	damaging	4.08	23.70	deleterious	0.48	0.55	0.3	neutral	0.75	disease	0.38	neutral	0.53	disease	1	0.99	deleterious	0.08	neutral	2	deleterious	0.74	deleterious	-2.64	low_impact	-0.23	medium_impact	2.38	high_impact	0.68	0.9	NA	NA	0.39	N	0.75	polymorphism	0.97	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7338	7338	A	C	MI.4953	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1435	479	K	Q	Aag/Cag	-5.47	0	0	probably_damaging	0.99	neutral	0.26	neutral	2.94	deleterious	-4.09	neutral	0.18	low_impact	1.72	0.55	damaging	0.1	damaging	1.60	13.87	neutral	0.53	0.6	0.35	neutral	0.32	neutral	0.12	neutral	0.47	neutral	1	0.99	deleterious	0.14	neutral	-2	neutral	0.68	deleterious	-2.64	low_impact	-0.06	medium_impact	0.49	medium_impact	0.82	0.9	NA	NA	0.48	N	0.66	polymorphism	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7339	7339	A	C	MI.4954	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1436	479	K	T	aAg/aCg	8.59	1	0	probably_damaging	1	deleterious	0.03	neutral	2.88	deleterious	-4.6	neutral	-0.64	high_impact	3.91	0.52	damaging	0.12	damaging	2.86	21.70	deleterious	0.28	0.55	0.46	neutral	0.62	disease	0.35	neutral	0.52	disease	0	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-0.65	medium_impact	2.51	high_impact	0.66	0.9	NA	NA	0.51	P	0.77	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7339	7339	A	T	MI.4955	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1436	479	K	M	aAg/aTg	8.59	1	0	probably_damaging	1	deleterious	0	neutral	2.85	deleterious	-6.18	neutral	-0.58	medium_impact	2.98	0.51	damaging	0.1	damaging	4.19	23.80	deleterious	0.28	0.55	0.73	disease	0.56	disease	0.22	neutral	0.52	disease	0	1	deleterious	0	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	1.65	medium_impact	0.51	0.9	NA	NA	0.49	P	0.89	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7340	7340	G	T	MI.4956	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1437	479	K	N	aaG/aaT	8.59	1	0	probably_damaging	1	neutral	0.14	neutral	2.89	deleterious	-4.53	neutral	-0.36	medium_impact	2.51	0.51	damaging	0.08	damaging	2.87	21.70	deleterious	0.6	0.65	0.42	neutral	0.5	disease	0.2	neutral	0.44	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.25	medium_impact	1.22	medium_impact	0.78	0.9	NA	NA	0.55	P	0.77	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7340	7340	G	C	MI.4957	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1437	479	K	N	aaG/aaC	8.59	1	0	probably_damaging	1	neutral	0.14	neutral	2.89	deleterious	-4.53	neutral	-0.36	medium_impact	2.51	0.51	damaging	0.08	damaging	2.76	21.10	deleterious	0.6	0.65	0.42	neutral	0.5	disease	0.2	neutral	0.44	neutral	1	1	deleterious	0.07	neutral	1	deleterious	0.72	deleterious	-3.58	low_impact	-0.25	medium_impact	1.22	medium_impact	0.78	0.9	NA	NA	0.55	P	0.77	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7341	7341	C	T	MI.4958	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1438	480	R	W	Cga/Tga	0.75	0.99	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-9	neutral	-2.33	high_impact	4.78	0.62	neutral	0.19	damaging	5.33	25.80	deleterious	0.21	0.55	0.87	disease	0.88	disease	0.6	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.73	0.9	NA	NA	0.65	P	1.00	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7341	7341	C	G	MI.4959	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1438	480	R	G	Cga/Gga	0.75	0.99	0	probably_damaging	0.98	deleterious	0	neutral	2.72	deleterious	-6.73	neutral	-2.02	high_impact	4.78	0.45	damaging	0.35	neutral	4.35	24.10	deleterious	0.3	0.55	0.31	neutral	0.81	disease	0.65	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-2.35	low_impact	-1.48	low_impact	3.32	high_impact	0.52	0.9	NA	NA	0.64	P	0.91	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8759	8759	T	C	MI.496	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	233	78	F	S	tTt/tCt	0.82	0.32	0	probably_damaging	0.99	deleterious	0	neutral	4.09	deleterious	-4.16	deleterious	-7.11	medium_impact	3.12	0.83	neutral	0.21	damaging	4.05	23.70	deleterious	0.18	0.65	0.84	disease	0.85	disease	0.65	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-2.65	low_impact	-1.4	low_impact	1.58	medium_impact	0.52	0.9	49.56	8.89	0.29	N	0.99	disease_causing	0.91	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7342	7342	G	A	MI.4960	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1439	480	R	Q	cGa/cAa	3.52	1	0	probably_damaging	0.96	deleterious	0	neutral	2.68	deleterious	-4.8	neutral	-1.07	high_impact	4.23	0.58	damaging	0.23	damaging	4.61	24.40	deleterious	0.38	0.55	0.36	neutral	0.77	disease	0.59	disease	0.56	disease	1	1	deleterious	0.02	neutral	6	deleterious	0.75	deleterious	-2.06	low_impact	-1.48	low_impact	2.81	high_impact	0.77	0.9	NA	NA	0.51	P	0.99	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7342	7342	G	C	MI.4961	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1439	480	R	P	cGa/cCa	3.52	1	0	probably_damaging	0.99	deleterious	0	neutral	2.71	deleterious	-7.14	neutral	-1.98	high_impact	4.78	0.52	damaging	0.23	damaging	4.41	24.10	deleterious	0.18	0.55	0.5	neutral	0.89	disease	0.72	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.64	low_impact	-1.48	low_impact	3.32	high_impact	0.54	0.9	NA	NA	0.67	P	0.99	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7342	7342	G	T	MI.4962	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1439	480	R	L	cGa/cTa	3.52	1	0	probably_damaging	0.96	deleterious	0	neutral	2.66	deleterious	-6.24	neutral	-2.03	high_impact	4.78	0.57	damaging	0.28	damaging	4.52	24.30	deleterious	0.28	0.55	0.45	neutral	0.88	disease	0.69	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-2.06	low_impact	-1.48	low_impact	3.32	high_impact	0.46	0.9	NA	NA	0.66	P	0.98	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7344	7344	A	C	MI.4963	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1441	481	K	Q	Aaa/Caa	-1.09	0	0	benign	0.17	neutral	0.45	neutral	2.89	deleterious	-4.09	neutral	-0.06	medium_impact	2.01	0.71	neutral	0.46	neutral	1.62	13.96	neutral	0.49	0.55	0.34	neutral	0.31	neutral	0.17	neutral	0.46	neutral	1	0.46	neutral	0.64	deleterious	-3	neutral	0.27	neutral	-0.11	medium_impact	0.14	medium_impact	0.76	medium_impact	0.76	0.9	14.04	56.76	0.53	N	0.29	polymorphism	0.94	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7344	7344	A	G	MI.4964	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1441	481	K	E	Aaa/Gaa	-1.09	0	0	benign	0.01	neutral	1	neutral	2.91	deleterious	-3.9	neutral	-0.27	low_impact	0.94	0.7	neutral	0.92	neutral	1.50	13.33	neutral	0.46	0.55	0.22	neutral	0.53	disease	0.22	neutral	0.44	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.16	neutral	1.12	medium_impact	1.86	high_impact	-0.23	medium_impact	0.80	0.9	14.04	56.76	0.33	N	0.00	polymorphism	0.9	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7345	7345	A	C	MI.4965	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1442	481	K	T	aAa/aCa	4.9	1	0	benign	0.23	neutral	0.46	neutral	2.9	deleterious	-4.6	neutral	-0.38	low_impact	1.58	0.77	neutral	0.63	neutral	1.63	13.99	neutral	0.3	0.55	0.34	neutral	0.33	neutral	0.21	neutral	0.46	neutral	1	0.44	neutral	0.62	deleterious	-6	neutral	0.35	neutral	-0.26	medium_impact	0.15	medium_impact	0.36	medium_impact	0.63	0.9	14.04	56.76	0.55	P	0.46	disease_causing	0.59	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7345	7345	A	T	MI.4966	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1442	481	K	M	aAa/aTa	4.9	1	0	possibly_damaging	0.82	neutral	0.1	neutral	2.88	deleterious	-6.18	neutral	-0.33	low_impact	1.89	0.73	neutral	0.44	neutral	2.58	19.95	deleterious	0.27	0.55	0.67	disease	0.27	neutral	0.21	neutral	0.56	disease	1	0.94	neutral	0.14	neutral	-3	neutral	0.65	deleterious	-1.38	low_impact	-0.34	medium_impact	0.65	medium_impact	0.52	0.9	14.04	56.76	0.59	P	0.62	disease_causing	0.76	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7346	7346	A	C	MI.4967	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1443	481	K	N	aaA/aaC	8.59	1	0	benign	0.23	neutral	0.38	neutral	2.86	deleterious	-4.53	neutral	-0.45	medium_impact	2.6	0.73	neutral	0.41	neutral	2.08	16.74	deleterious	0.56	0.6	0.33	neutral	0.41	neutral	0.36	neutral	0.46	neutral	1	0.54	neutral	0.58	deleterious	-3	neutral	0.35	neutral	-0.26	medium_impact	0.07	medium_impact	1.3	medium_impact	0.81	0.9	14.04	56.76	0.62	P	0.40	disease_causing	0.97	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7346	7346	A	T	MI.4968	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1443	481	K	N	aaA/aaT	8.59	1	0	benign	0.23	neutral	0.38	neutral	2.86	deleterious	-4.53	neutral	-0.45	medium_impact	2.6	0.73	neutral	0.41	neutral	2.32	18.28	deleterious	0.56	0.6	0.33	neutral	0.41	neutral	0.36	neutral	0.46	neutral	1	0.54	neutral	0.58	deleterious	-3	neutral	0.35	neutral	-0.26	medium_impact	0.07	medium_impact	1.3	medium_impact	0.81	0.9	14.04	56.76	0.62	P	0.40	disease_causing	0.97	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7347	7347	G	C	MI.4969	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1444	482	V	L	Gtc/Ctc	0.98	1	0	benign	0	neutral	0.26	neutral	2.93	neutral	-0.36	neutral	-0.39	medium_impact	2.19	0.66	neutral	0.65	neutral	0.47	7.18	deleterious	0.44	0.55	0.13	neutral	0.39	neutral	0.16	neutral	0.44	neutral	1	0.74	neutral	0.63	deleterious	-3	neutral	0.09	neutral	2.07	high_impact	-0.06	medium_impact	0.92	medium_impact	0.70	0.9	9.94	12.51	0.58	P	0.55	disease_causing	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8759	8759	T	G	MI.497	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	233	78	F	C	tTt/tGt	0.82	0.32	0	probably_damaging	1	deleterious	0.04	neutral	4.07	deleterious	-5.66	deleterious	-7.15	medium_impact	3.25	0.84	neutral	0.16	damaging	3.95	23.60	deleterious	0.17	0.65	0.92	disease	0.88	disease	0.68	disease	0.82	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-3.6	low_impact	-0.49	medium_impact	1.69	medium_impact	0.39	0.9	49.56	8.89	0.3	N	1.00	disease_causing	0.94	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7347	7347	G	T	MI.4970	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1444	482	V	F	Gtc/Ttc	0.98	1	0	benign	0.27	neutral	0.27	neutral	2.82	neutral	-2.66	neutral	-0.83	medium_impact	2.67	0.64	neutral	0.53	neutral	1.04	10.91	neutral	0.24	0.55	0.4	neutral	0.64	disease	0.21	neutral	0.44	neutral	1	0.67	neutral	0.5	deleterious	-3	neutral	0.34	neutral	-0.35	medium_impact	-0.05	medium_impact	1.37	medium_impact	0.65	0.9	9.94	12.51	0.53	P	0.84	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7347	7347	G	A	MI.4971	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1444	482	V	I	Gtc/Atc	0.98	1	0	benign	0	neutral	0.27	neutral	2.91	neutral	1.45	neutral	0.03	neutral_impact	0.53	0.77	neutral	0.88	neutral	0.14	4.03	deleterious	0.59	0.65	0.2	neutral	0.19	neutral	0.16	neutral	0.36	neutral	3	0.73	neutral	0.64	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	-0.05	medium_impact	-0.61	medium_impact	0.79	0.9	9.94	12.51	0.57	P	0.18	disease_causing	0.96	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7348	7348	T	G	MI.4972	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1445	482	V	G	gTc/gGc	5.13	1	0	benign	0.16	deleterious	0.03	neutral	2.83	deleterious	-3.89	neutral	-1.61	medium_impact	3.13	0.65	neutral	0.56	neutral	2.17	17.32	deleterious	0.21	0.55	0.49	neutral	0.64	disease	0.46	neutral	0.49	neutral	0	0.97	neutral	0.44	neutral	1	deleterious	0.28	neutral	-0.08	medium_impact	-0.65	medium_impact	1.79	medium_impact	0.56	0.9	9.94	12.51	0.56	P	0.72	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7348	7348	T	A	MI.4973	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1445	482	V	D	gTc/gAc	5.13	1	0	benign	0.33	deleterious	0.01	neutral	2.79	deleterious	-4.34	neutral	-1.47	high_impact	3.83	0.65	neutral	0.42	neutral	3.04	22.40	deleterious	0.17	0.55	0.54	disease	0.8	disease	0.52	disease	0.71	disease	4	0.99	deleterious	0.34	neutral	2	deleterious	0.49	deleterious	-0.47	medium_impact	-0.92	medium_impact	2.44	high_impact	0.54	0.9	9.94	12.51	0.5	P	0.83	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7348	7348	T	C	MI.4974	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1445	482	V	A	gTc/gCc	5.13	1	0	benign	0.01	neutral	0.07	neutral	2.92	neutral	-2.06	neutral	-0.81	low_impact	1.36	0.67	neutral	0.62	neutral	0.66	8.57	deleterious	0.43	0.55	0.27	neutral	0.32	neutral	0.38	neutral	0.44	neutral	1	0.93	neutral	0.53	deleterious	-6	neutral	0.13	neutral	1.12	medium_impact	-0.43	medium_impact	0.16	medium_impact	0.40	0.9	9.94	12.51	0.66	P	0.47	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7350	7350	C	G	MI.4975	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1447	483	L	V	Cta/Gta	-20	0	0	benign	0.01	neutral	0.12	neutral	2.93	deleterious	-3.87	neutral	-0.13	low_impact	1.49	0.73	neutral	0.84	neutral	0.12	3.82	deleterious	0.6	0.65	0.17	neutral	0.32	neutral	0.12	neutral	0.45	neutral	1	0.88	neutral	0.56	deleterious	-6	neutral	0.10	neutral	1.12	medium_impact	-0.29	medium_impact	0.28	medium_impact	0.55	0.9	7.6	20.3	0.58	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7350	7350	C	A	MI.4976	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1447	483	L	M	Cta/Ata	-20	0	0	benign	0	neutral	0.12	neutral	2.86	deleterious	-4.68	neutral	-0.11	low_impact	1.4	0.73	neutral	0.96	neutral	0.49	7.32	deleterious	0.33	0.55	0.31	neutral	0.26	neutral	0.14	neutral	0.44	neutral	1	0.88	neutral	0.56	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	-0.29	medium_impact	0.19	medium_impact	0.75	0.9	7.6	20.3	0.58	P	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7351	7351	T	A	MI.4977	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1448	483	L	Q	cTa/cAa	-12.62	0	0	benign	0.06	neutral	0.05	neutral	2.85	deleterious	-7.38	neutral	-1.16	medium_impact	3.08	0.73	neutral	0.82	neutral	1.32	12.35	neutral	0.26	0.55	0.32	neutral	0.69	disease	0.22	neutral	0.53	disease	1	0.95	neutral	0.5	deleterious	-3	neutral	0.19	neutral	0.37	medium_impact	-0.52	medium_impact	1.75	medium_impact	0.59	0.9	7.6	20.3	0.46	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7351	7351	T	G	MI.4978	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1448	483	L	R	cTa/cGa	-12.62	0	0	benign	0.02	deleterious	0.02	neutral	2.89	deleterious	-7.35	neutral	-1.25	medium_impact	3.28	0.66	neutral	0.63	neutral	2.43	19.00	deleterious	0.35	0.55	0.2	neutral	0.79	disease	0.45	neutral	0.64	disease	3	0.98	neutral	0.5	deleterious	1	deleterious	0.20	neutral	0.83	medium_impact	-0.75	medium_impact	1.93	medium_impact	0.52	0.9	7.6	20.3	0.4	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7351	7351	T	C	MI.4979	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1448	483	L	P	cTa/cCa	-12.62	0	0	benign	0.21	deleterious	0.03	neutral	2.88	deleterious	-7.82	neutral	-1.35	medium_impact	3.42	0.73	neutral	0.84	neutral	2.09	16.81	deleterious	0.24	0.55	0.48	neutral	0.81	disease	0.4	neutral	0.58	disease	2	0.97	neutral	0.41	neutral	1	deleterious	0.38	neutral	-0.22	medium_impact	-0.65	medium_impact	2.06	high_impact	0.37	0.9	7.6	20.3	0.37	N	0.05	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8759	8759	T	A	MI.498	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	233	78	F	Y	tTt/tAt	0.82	0.32	0	probably_damaging	0.98	neutral	0.14	neutral	4.25	deleterious	-3.53	deleterious	-2.63	medium_impact	2.02	0.89	neutral	0.26	damaging	2.88	21.80	deleterious	0.27	0.65	0.81	disease	0.72	disease	0.49	neutral	0.62	disease	2	0.99	deleterious	0.08	neutral	1	deleterious	0.80	deleterious	-2.36	low_impact	-0.15	medium_impact	0.63	medium_impact	0.65	0.9	49.56	8.89	0.38	N	0.89	disease_causing	0.57	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7353	7353	A	C	MI.4980	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1450	484	M	L	Ata/Cta	-8.01	0	0	benign	0	neutral	0.62	neutral	3.1	neutral	2.26	neutral	-0.1	neutral_impact	0	0.79	neutral	0.93	neutral	0.07	3.32	deleterious	0.6	0.65	0.15	neutral	0.29	neutral	0.24	neutral	0.43	neutral	1	0.38	neutral	0.81	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.31	medium_impact	-1.1	low_impact	0.40	0.9	16.57	30.87	0.34	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7353	7353	A	T	MI.4981	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1450	484	M	L	Ata/Tta	-8.01	0	0	benign	0	neutral	0.62	neutral	3.1	neutral	2.26	neutral	-0.1	neutral_impact	0	0.79	neutral	0.93	neutral	0.18	4.43	deleterious	0.6	0.65	0.15	neutral	0.29	neutral	0.24	neutral	0.43	neutral	1	0.38	neutral	0.81	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.31	medium_impact	-1.1	low_impact	0.40	0.9	16.57	30.87	0.35	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7353	7353	A	G	MI.4982	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1450	484	M	V	Ata/Gta	-8.01	0	0	benign	0	neutral	0.45	neutral	3.06	neutral	1.02	neutral	-0.28	neutral_impact	0.34	0.84	neutral	0.96	neutral	-0.35	0.51	neutral	0.64	0.65	0.18	neutral	0.34	neutral	0.26	neutral	0.45	neutral	1	0.55	neutral	0.73	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.14	medium_impact	-0.79	medium_impact	0.29	0.9	16.57	30.87	0.37	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7354	7354	T	A	MI.4983	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1451	484	M	K	aTa/aAa	-2.48	0	0	benign	0.01	neutral	0.26	neutral	3.01	neutral	-0.86	neutral	-0.47	neutral_impact	0.41	0.77	neutral	0.74	neutral	1.27	12.10	neutral	0.28	0.55	0.19	neutral	0.6	disease	0.36	neutral	0.49	neutral	0	0.74	neutral	0.63	deleterious	-6	neutral	0.12	neutral	1.12	medium_impact	-0.06	medium_impact	-0.72	medium_impact	0.49	0.9	16.57	30.87	0.36	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7354	7354	T	C	MI.4984	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1451	484	M	T	aTa/aCa	-2.48	0	0	benign	0	neutral	0.42	neutral	3.04	neutral	-0.32	neutral	-0.27	neutral_impact	-0.34	0.78	neutral	0.99	neutral	-0.34	0.53	neutral	0.49	0.55	0.22	neutral	0.31	neutral	0.31	neutral	0.45	neutral	1	0.58	neutral	0.71	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.12	medium_impact	-1.41	low_impact	0.09	0.9	16.57	30.87	0.36	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7355	7355	A	C	MI.4985	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1452	484	M	I	atA/atC	-0.86	0	0	benign	0	neutral	0.41	neutral	3.03	neutral	1.06	neutral	-0.13	neutral_impact	0.52	0.81	neutral	0.86	neutral	0.21	4.77	deleterious	0.61	0.65	0.18	neutral	0.36	neutral	0.14	neutral	0.45	neutral	1	0.59	neutral	0.71	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.11	medium_impact	-0.62	medium_impact	0.35	0.9	16.57	30.87	0.5	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7355	7355	A	T	MI.4986	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1452	484	M	I	atA/atT	-0.86	0	0	benign	0	neutral	0.41	neutral	3.03	neutral	1.06	neutral	-0.13	neutral_impact	0.52	0.81	neutral	0.86	neutral	0.44	6.99	deleterious	0.61	0.65	0.18	neutral	0.36	neutral	0.14	neutral	0.45	neutral	1	0.59	neutral	0.71	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.11	medium_impact	-0.62	medium_impact	0.35	0.9	16.57	30.87	0.5	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7356	7356	G	C	MI.4987	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1453	485	V	L	Gta/Cta	-2.24	0	0	benign	0	neutral	0.33	neutral	3.02	neutral	0.79	neutral	-0.04	neutral_impact	0.48	0.71	neutral	0.61	neutral	-0.09	1.79	neutral	0.55	0.6	0.2	neutral	0.28	neutral	0.25	neutral	0.43	neutral	1	0.67	neutral	0.67	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.02	medium_impact	-0.66	medium_impact	0.55	0.9	14.62	44.85	0.47	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7356	7356	G	A	MI.4988	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1453	485	V	M	Gta/Ata	-2.24	0	0	benign	0	neutral	0.11	neutral	2.98	neutral	1.83	neutral	0.18	neutral_impact	0.74	0.77	neutral	0.63	neutral	0.58	8.02	deleterious	0.46	0.55	0.46	neutral	0.23	neutral	0.17	neutral	0.44	neutral	1	0.89	neutral	0.56	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	-0.31	medium_impact	-0.42	medium_impact	0.65	0.9	14.62	44.85	0.55	P	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7356	7356	G	T	MI.4989	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1453	485	V	L	Gta/Tta	-2.24	0	0	benign	0	neutral	0.33	neutral	3.02	neutral	0.79	neutral	-0.04	neutral_impact	0.48	0.71	neutral	0.61	neutral	0.06	3.21	deleterious	0.55	0.6	0.2	neutral	0.28	neutral	0.25	neutral	0.43	neutral	1	0.67	neutral	0.67	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.02	medium_impact	-0.66	medium_impact	0.55	0.9	14.62	44.85	0.48	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8760	8760	T	A	MI.499	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	234	78	F	L	ttT/ttA	2.9	0.43	0	probably_damaging	0.98	neutral	0.52	neutral	4.21	neutral	-2.28	deleterious	-5.21	low_impact	1.2	0.84	neutral	0.29	neutral	3.25	22.80	deleterious	0.33	0.65	0.57	disease	0.63	disease	0.47	neutral	0.49	neutral	0	0.98	neutral	0.27	neutral	-2	neutral	0.74	deleterious	-2.36	low_impact	0.31	medium_impact	-0.07	medium_impact	0.55	0.9	49.56	8.89	0.29	N	0.89	disease_causing	0.93	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7357	7357	T	G	MI.4990	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1454	485	V	G	gTa/gGa	-0.17	0	0	benign	0.03	neutral	0.38	neutral	2.98	neutral	1.49	neutral	-0.11	low_impact	1.31	0.71	neutral	0.61	neutral	0.65	8.47	deleterious	0.23	0.55	0.18	neutral	0.41	neutral	0.42	neutral	0.44	neutral	1	0.6	neutral	0.68	deleterious	-6	neutral	0.12	neutral	0.66	medium_impact	0.07	medium_impact	0.11	medium_impact	0.47	0.9	14.62	44.85	0.46	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7357	7357	T	C	MI.4991	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1454	485	V	A	gTa/gCa	-0.17	0	0	benign	0	neutral	0.77	neutral	3.02	neutral	0.7	neutral	0.29	low_impact	1.05	0.77	neutral	0.7	neutral	0.07	3.31	deleterious	0.5	0.55	0.18	neutral	0.24	neutral	0.35	neutral	0.41	neutral	2	0.23	neutral	0.89	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.48	medium_impact	-0.13	medium_impact	0.41	0.9	14.62	44.85	0.31	N	0.65	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7357	7357	T	A	MI.4992	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1454	485	V	E	gTa/gAa	-0.17	0	0	benign	0.03	neutral	1	neutral	3.06	neutral	-0.97	neutral	0.04	medium_impact	2.25	0.66	neutral	0.5	neutral	1.85	15.29	deleterious	0.2	0.55	0.18	neutral	0.64	disease	0.43	neutral	0.52	disease	0	0.03	neutral	0.99	deleterious	-3	neutral	0.16	neutral	0.66	medium_impact	1.86	high_impact	0.98	medium_impact	0.49	0.9	14.62	44.85	0.29	N	0.91	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7359	7359	G	C	MI.4993	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1456	486	E	Q	Gaa/Caa	-4.78	0	0	benign	0.29	neutral	0.34	neutral	2.99	neutral	0.11	neutral	0.07	medium_impact	2.19	0.71	neutral	0.39	neutral	-0.27	0.78	neutral	0.55	0.6	0.38	neutral	0.17	neutral	0.36	neutral	0.33	neutral	3	0.59	neutral	0.53	deleterious	-3	neutral	0.32	neutral	-0.39	medium_impact	0.03	medium_impact	0.92	medium_impact	0.68	0.9	7.02	40.53	0.44	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7359	7359	G	A	MI.4994	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1456	486	E	K	Gaa/Aaa	-4.78	0	0	benign	0.12	neutral	0.36	neutral	3.03	neutral	0.29	neutral	-0.14	low_impact	0.84	0.62	neutral	0.27	damaging	0.64	8.44	deleterious	0.29	0.55	0.31	neutral	0.28	neutral	0.44	neutral	0.42	neutral	2	0.58	neutral	0.62	deleterious	-6	neutral	0.19	neutral	0.06	medium_impact	0.05	medium_impact	-0.32	medium_impact	0.69	0.9	7.02	40.53	0.38	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7360	7360	A	T	MI.4995	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1457	486	E	V	gAa/gTa	3.52	1	0	benign	0.41	neutral	0.52	neutral	3.05	neutral	2.56	neutral	-0.1	medium_impact	2.25	0.66	neutral	0.29	neutral	0.53	7.66	deleterious	0.23	0.55	0.57	disease	0.32	neutral	0.41	neutral	0.56	disease	1	0.43	neutral	0.56	deleterious	-3	neutral	0.44	deleterious	-0.61	medium_impact	0.21	medium_impact	0.98	medium_impact	0.56	0.9	7.02	40.53	0.46	N	0.63	disease_causing	0.9	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7360	7360	A	G	MI.4996	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1457	486	E	G	gAa/gGa	3.52	1	0	benign	0.12	neutral	0.38	neutral	2.99	neutral	0.28	neutral	-0.64	medium_impact	2.33	0.67	neutral	0.3	neutral	0.75	9.13	deleterious	0.38	0.55	0.42	neutral	0.19	neutral	0.48	neutral	0.37	neutral	3	0.56	neutral	0.63	deleterious	-3	neutral	0.19	neutral	0.06	medium_impact	0.07	medium_impact	1.05	medium_impact	0.45	0.9	7.02	40.53	0.55	P	0.34	disease_causing	0.82	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7360	7360	A	C	MI.4997	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1457	486	E	A	gAa/gCa	3.52	1	0	benign	0.12	neutral	0.55	neutral	3.04	neutral	3.23	neutral	-0.17	medium_impact	1.98	0.71	neutral	0.35	neutral	-0.43	0.32	neutral	0.37	0.55	0.31	neutral	0.21	neutral	0.4	neutral	0.36	neutral	3	0.36	neutral	0.72	deleterious	-3	neutral	0.22	neutral	0.06	medium_impact	0.24	medium_impact	0.73	medium_impact	0.49	0.9	7.02	40.53	0.47	N	0.14	disease_causing	0.79	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7361	7361	A	C	MI.4998	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1458	486	E	D	gaA/gaC	6.75	1	0	benign	0.12	neutral	0.26	neutral	2.98	neutral	-0.86	neutral	-0.27	low_impact	1.22	0.71	neutral	0.91	neutral	0.21	4.76	deleterious	0.5	0.55	0.24	neutral	0.2	neutral	0.34	neutral	0.36	neutral	3	0.7	neutral	0.57	deleterious	-6	neutral	0.15	neutral	0.06	medium_impact	-0.06	medium_impact	0.03	medium_impact	0.75	0.9	7.02	40.53	0.68	P	0.01	disease_causing	0.52	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7361	7361	A	T	MI.4999	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1458	486	E	D	gaA/gaT	6.75	1	0	benign	0.12	neutral	0.26	neutral	2.98	neutral	-0.86	neutral	-0.27	low_impact	1.22	0.71	neutral	0.91	neutral	0.34	6.04	deleterious	0.5	0.55	0.24	neutral	0.2	neutral	0.34	neutral	0.36	neutral	3	0.7	neutral	0.57	deleterious	-6	neutral	0.15	neutral	0.06	medium_impact	-0.06	medium_impact	0.03	medium_impact	0.75	0.9	7.02	40.53	0.68	P	0.01	disease_causing	0.52	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8529	8529	G	T	MI.5	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	3	1	M	I	atG/atT	7.53	1	0	possibly_damaging	0.72	deleterious	0	neutral	4.58	neutral	0.17	deleterious	-3.33	NA	NA	0.68	neutral	0.12	damaging	4.28	24.00	deleterious	0.46	0.65	0.77	disease	0.44	neutral	0.64	disease	0.61	disease	2	1	deleterious	0.14	neutral	3	deleterious	0.68	deleterious	NA	NA	NA	NA	NA	NA	0.55	0.9	50	8.74	0.61	P	0.94	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8548	8548	T	G	MI.50	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	22	8	S	A	Tca/Gca	-0.1	0.83	0	benign	0.03	neutral	0.37	neutral	4.67	neutral	-0.28	neutral	-1.32	low_impact	1.84	0.82	neutral	0.56	neutral	1.55	13.58	neutral	0.4	0.65	0.58	disease	0.39	neutral	0.47	neutral	0.61	disease	2	0.61	neutral	0.67	deleterious	-6	neutral	0.23	neutral	0.68	medium_impact	0.16	medium_impact	0.48	medium_impact	0.57	0.9	21.24	17.86	0.32	N	0.27	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8760	8760	T	G	MI.500	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	234	78	F	L	ttT/ttG	2.9	0.43	0	probably_damaging	0.98	neutral	0.52	neutral	4.21	neutral	-2.28	deleterious	-5.21	low_impact	1.2	0.84	neutral	0.29	neutral	3.12	22.50	deleterious	0.33	0.65	0.57	disease	0.63	disease	0.47	neutral	0.49	neutral	0	0.98	neutral	0.27	neutral	-2	neutral	0.74	deleterious	-2.36	low_impact	0.31	medium_impact	-0.07	medium_impact	0.55	0.9	49.56	8.89	0.27	N	0.89	disease_causing	0.93	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7362	7362	G	A	MI.5000	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1459	487	E	K	Gaa/Aaa	-0.17	0	0	benign	0	neutral	0.28	neutral	3.04	neutral	3.9	neutral	-0.05	neutral_impact	-1.38	0.61	neutral	0.47	neutral	1.26	12.04	neutral	0.31	0.55	0.26	neutral	0.35	neutral	0.29	neutral	0.45	neutral	1	0.72	neutral	0.64	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	-0.04	medium_impact	-2.37	low_impact	0.65	0.9	16.18	50.61	0.47	N	0.23	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7362	7362	G	C	MI.5001	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1459	487	E	Q	Gaa/Caa	-0.17	0	0	benign	0	neutral	0.3	neutral	3.01	neutral	-0.19	neutral	0.25	neutral_impact	-1.54	0.74	neutral	0.91	neutral	-0.07	2.00	deleterious	0.47	0.55	0.31	neutral	0.11	neutral	0.21	neutral	0.32	neutral	4	0.7	neutral	0.65	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	-0.01	medium_impact	-2.52	low_impact	0.63	0.9	16.18	50.61	0.54	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7363	7363	A	G	MI.5002	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1460	487	E	G	gAa/gGa	-2.48	0	0	benign	0	neutral	0.34	neutral	3	neutral	-1.03	neutral	-0.33	neutral_impact	-0.5	0.68	neutral	0.76	neutral	0.82	9.60	deleterious	0.29	0.55	0.48	neutral	0.26	neutral	0.51	disease	0.44	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.03	medium_impact	-1.56	low_impact	0.47	0.9	16.18	50.61	0.42	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7363	7363	A	C	MI.5003	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1460	487	E	A	gAa/gCa	-2.48	0	0	benign	0	neutral	0.5	neutral	3.06	neutral	-0.34	neutral	-0.18	neutral_impact	-0.62	0.67	neutral	0.81	neutral	-0.04	2.26	deleterious	0.3	0.55	0.31	neutral	0.24	neutral	0.44	neutral	0.43	neutral	1	0.5	neutral	0.75	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.19	medium_impact	-1.67	low_impact	0.49	0.9	16.18	50.61	0.4	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7363	7363	A	T	MI.5004	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1460	487	E	V	gAa/gTa	-2.48	0	0	benign	0	neutral	0.49	neutral	3.05	neutral	-1.13	neutral	-0.25	neutral_impact	0.7	0.64	neutral	0.69	neutral	0.44	6.92	deleterious	0.22	0.55	0.49	neutral	0.38	neutral	0.42	neutral	0.42	neutral	2	0.51	neutral	0.75	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	0.18	medium_impact	-0.45	medium_impact	0.59	0.9	16.18	50.61	0.39	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7364	7364	A	C	MI.5005	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1461	487	E	D	gaA/gaC	4.67	0.66	0.01	benign	0	neutral	0.21	neutral	2.99	neutral	-0.62	neutral	-0.1	neutral_impact	0.34	0.58	damaging	0.44	neutral	0.60	8.14	deleterious	0.41	0.55	0.26	neutral	0.27	neutral	0.34	neutral	0.43	neutral	1	0.79	neutral	0.61	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	-0.13	medium_impact	-0.79	medium_impact	0.70	0.9	16.18	50.61	0.49	N	0.24	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7364	7364	A	T	MI.5006	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1461	487	E	D	gaA/gaT	4.67	0.66	0.01	benign	0	neutral	0.21	neutral	2.99	neutral	-0.62	neutral	-0.1	neutral_impact	0.34	0.58	damaging	0.44	neutral	0.70	8.81	deleterious	0.41	0.55	0.26	neutral	0.27	neutral	0.34	neutral	0.43	neutral	1	0.79	neutral	0.61	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	-0.13	medium_impact	-0.79	medium_impact	0.70	0.9	16.18	50.61	0.49	N	0.24	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7365	7365	C	A	MI.5007	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1462	488	P	T	Ccc/Acc	-3.63	0	0	benign	0	neutral	1	neutral	3.03	neutral	1.16	neutral	0.54	neutral_impact	-0.78	0.73	neutral	0.99	neutral	-0.14	1.47	neutral	0.38	0.55	0.35	neutral	0.12	neutral	0.22	neutral	0.29	neutral	4	0	neutral	1	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	1.86	high_impact	-1.82	low_impact	0.57	0.9	15.79	41.36	0.36	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7365	7365	C	G	MI.5008	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1462	488	P	A	Ccc/Gcc	-3.63	0	0	benign	0.01	neutral	0.42	neutral	3.04	neutral	1.39	neutral	0.28	low_impact	1.21	0.78	neutral	0.91	neutral	-0.32	0.58	neutral	0.38	0.55	0.41	neutral	0.18	neutral	0.37	neutral	0.31	neutral	4	0.57	neutral	0.71	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.12	medium_impact	0.02	medium_impact	0.63	0.9	15.79	41.36	0.39	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7365	7365	C	T	MI.5009	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1462	488	P	S	Ccc/Tcc	-3.63	0	0	benign	0	neutral	0.45	neutral	3.02	neutral	2.96	neutral	0.33	neutral_impact	0.39	0.81	neutral	0.97	neutral	0.35	6.19	deleterious	0.42	0.55	0.46	neutral	0.18	neutral	0.21	neutral	0.3	neutral	4	0.55	neutral	0.73	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.14	medium_impact	-0.74	medium_impact	0.31	0.9	15.79	41.36	0.42	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8761	8761	A	T	MI.501	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	235	79	I	F	Att/Ttt	-2.88	0	0	probably_damaging	0.99	deleterious	0	neutral	3.33	deleterious	-6.11	deleterious	-3	medium_impact	2.48	0.84	neutral	0.39	neutral	3.63	23.20	deleterious	0.27	0.65	0.81	disease	0.79	disease	0.59	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-2.65	low_impact	-1.4	low_impact	1.03	medium_impact	0.74	0.9	49.56	8.5	0.32	N	0.90	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7366	7366	C	G	MI.5010	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1463	488	P	R	cCc/cGc	0.52	0	0	benign	0.09	neutral	0.36	neutral	3.01	neutral	-0.04	neutral	0.11	low_impact	1.9	0.68	neutral	0.47	neutral	0.57	7.95	deleterious	0.3	0.55	0.58	disease	0.38	neutral	0.43	neutral	0.61	disease	2	0.59	neutral	0.64	deleterious	-6	neutral	0.19	neutral	0.19	medium_impact	0.05	medium_impact	0.66	medium_impact	0.51	0.9	15.79	41.36	0.47	N	0.38	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7366	7366	C	T	MI.5011	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1463	488	P	L	cCc/cTc	0.52	0	0	benign	0	neutral	0.46	neutral	3.13	neutral	4.48	neutral	0.87	neutral_impact	-0.57	0.72	neutral	0.8	neutral	-0.15	1.39	neutral	0.31	0.55	0.36	neutral	0.19	neutral	0.43	neutral	0.34	neutral	3	0.54	neutral	0.73	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.15	medium_impact	-1.63	low_impact	0.70	0.9	15.79	41.36	0.45	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7366	7366	C	A	MI.5012	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1463	488	P	H	cCc/cAc	0.52	0	0	benign	0.3	neutral	0.1	neutral	2.98	neutral	-0.7	neutral	-0.01	low_impact	1.9	0.72	neutral	0.49	neutral	1.31	12.32	neutral	0.36	0.55	0.7	disease	0.25	neutral	0.39	neutral	0.56	disease	1	0.88	neutral	0.4	neutral	-6	neutral	0.28	neutral	-0.41	medium_impact	-0.34	medium_impact	0.66	medium_impact	0.46	0.9	15.79	41.36	0.51	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7368	7368	T	C	MI.5013	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1465	489	S	P	Tcc/Ccc	-8.47	0	0	benign	0	neutral	0.45	neutral	2.91	deleterious	-3.51	neutral	-0.46	low_impact	1.05	0.79	neutral	0.77	neutral	0.48	7.26	deleterious	0.29	0.55	0.52	disease	0.57	disease	0.26	neutral	0.47	neutral	1	0.55	neutral	0.73	deleterious	-6	neutral	0.19	neutral	2.07	high_impact	0.14	medium_impact	-0.13	medium_impact	0.66	0.9	13.45	14.46	0.32	N	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7368	7368	T	G	MI.5014	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1465	489	S	A	Tcc/Gcc	-8.47	0	0	benign	0	neutral	0.29	neutral	3.03	neutral	-2.51	neutral	-0.58	low_impact	1.36	0.77	neutral	0.98	neutral	0.54	7.72	deleterious	0.36	0.55	0.17	neutral	0.24	neutral	0.4	neutral	0.43	neutral	1	0.71	neutral	0.65	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	-0.02	medium_impact	0.16	medium_impact	0.69	0.9	13.45	14.46	0.44	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7368	7368	T	A	MI.5015	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1465	489	S	T	Tcc/Acc	-8.47	0	0	benign	0	neutral	0.39	neutral	2.91	neutral	-2.87	neutral	-0.26	low_impact	1.01	0.81	neutral	1	neutral	0.28	5.48	deleterious	0.32	0.55	0.27	neutral	0.24	neutral	0.25	neutral	0.44	neutral	1	0.61	neutral	0.7	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.09	medium_impact	-0.17	medium_impact	0.75	0.9	13.45	14.46	0.48	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7369	7369	C	T	MI.5016	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1466	489	S	F	tCc/tTc	-2.48	0	0	benign	0	neutral	0.07	neutral	2.87	deleterious	-4.15	neutral	-1.13	medium_impact	2.8	0.7	neutral	0.44	neutral	1.22	11.87	neutral	0.27	0.55	0.41	neutral	0.54	disease	0.56	disease	0.62	disease	2	0.93	neutral	0.54	deleterious	-3	neutral	0.16	neutral	2.07	high_impact	-0.43	medium_impact	1.49	medium_impact	0.39	0.9	13.45	14.46	0.43	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7369	7369	C	G	MI.5017	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1466	489	S	C	tCc/tGc	-2.48	0	0	benign	0.2	deleterious	0.02	neutral	2.84	deleterious	-5.32	neutral	-1.04	medium_impact	3.35	0.68	neutral	0.64	neutral	0.97	10.49	neutral	0.34	0.55	0.6	disease	0.57	disease	0.5	neutral	0.48	neutral	0	0.98	neutral	0.41	neutral	1	deleterious	0.25	neutral	-0.19	medium_impact	-0.75	medium_impact	1.99	medium_impact	0.70	0.9	13.45	14.46	0.39	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7369	7369	C	A	MI.5018	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1466	489	S	Y	tCc/tAc	-2.48	0	0	benign	0.02	neutral	0.11	neutral	2.87	deleterious	-4.3	neutral	-0.92	medium_impact	2.38	0.8	neutral	0.71	neutral	0.94	10.34	neutral	0.27	0.55	0.46	neutral	0.6	disease	0.55	disease	0.62	disease	2	0.89	neutral	0.55	deleterious	-3	neutral	0.16	neutral	0.83	medium_impact	-0.31	medium_impact	1.1	medium_impact	0.69	0.9	13.45	14.46	0.37	N	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7371	7371	A	G	MI.5019	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1468	490	M	V	Ata/Gta	-8.93	0	0	benign	0	neutral	0.17	neutral	3.05	neutral	1.69	neutral	-0.14	neutral_impact	0.4	0.73	neutral	0.88	neutral	1.09	11.15	neutral	0.58	0.65	0.15	neutral	0.35	neutral	0.46	neutral	0.44	neutral	1	0.83	neutral	0.59	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	-0.19	medium_impact	-0.73	medium_impact	0.55	0.9	9.55	41.4	0.4	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8761	8761	A	C	MI.502	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	235	79	I	L	Att/Ctt	-2.88	0	0	probably_damaging	0.93	neutral	0.91	neutral	3.64	deleterious	-3.03	neutral	-0.51	neutral_impact	-0.12	0.73	neutral	0.68	neutral	0.96	10.44	neutral	0.31	0.65	0.44	neutral	0.21	neutral	0.28	neutral	0.37	neutral	3	0.92	neutral	0.49	deleterious	-2	neutral	0.63	deleterious	-1.82	low_impact	0.86	medium_impact	-1.2	low_impact	0.59	0.9	49.56	8.5	0.25	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7371	7371	A	C	MI.5020	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1468	490	M	L	Ata/Cta	-8.93	0	0	benign	0	neutral	0.06	neutral	3.09	neutral	1.14	neutral	-0.2	neutral_impact	0.4	0.7	neutral	0.66	neutral	1.63	14.01	neutral	0.52	0.6	0.19	neutral	0.34	neutral	0.4	neutral	0.44	neutral	1	0.94	neutral	0.53	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	-0.47	medium_impact	-0.73	medium_impact	0.55	0.9	9.55	41.4	0.5	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7371	7371	A	T	MI.5021	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1468	490	M	L	Ata/Tta	-8.93	0	0	benign	0	neutral	0.06	neutral	3.09	neutral	1.14	neutral	-0.2	neutral_impact	0.4	0.7	neutral	0.66	neutral	1.77	14.79	neutral	0.52	0.6	0.19	neutral	0.34	neutral	0.4	neutral	0.44	neutral	1	0.94	neutral	0.53	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	-0.47	medium_impact	-0.73	medium_impact	0.55	0.9	9.55	41.4	0.5	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7372	7372	T	A	MI.5022	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1469	490	M	K	aTa/aAa	4.67	0.98	0	benign	0	deleterious	0.04	neutral	3.01	neutral	1.11	neutral	0.16	neutral_impact	0.55	0.57	damaging	0.49	neutral	2.18	17.40	deleterious	0.32	0.55	0.22	neutral	0.57	disease	0.51	disease	0.53	disease	1	0.96	neutral	0.52	deleterious	-2	neutral	0.13	neutral	2.07	high_impact	-0.58	medium_impact	-0.59	medium_impact	0.62	0.9	9.55	41.4	0.53	P	0.16	polymorphism	0.99	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7372	7372	T	C	MI.5023	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1469	490	M	T	aTa/aCa	4.67	0.98	0	benign	0	neutral	0.95	neutral	3.1	neutral	4.65	neutral	0.73	neutral_impact	-2.98	0.79	neutral	0.97	neutral	-1.21	0.01	neutral	0.53	0.6	0.22	neutral	0.14	neutral	0.27	neutral	0.24	neutral	5	0.05	neutral	0.98	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.9	medium_impact	-3.85	low_impact	0.24	0.9	9.55	41.4	0.49	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7373	7373	A	C	MI.5024	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1470	490	M	I	atA/atC	2.83	0.97	0	benign	0	deleterious	0.02	neutral	3.05	neutral	0.67	neutral	-0.22	neutral_impact	-0.38	0.75	neutral	0.8	neutral	1.58	13.74	neutral	0.55	0.6	0.26	neutral	0.35	neutral	0.46	neutral	0.44	neutral	1	0.98	neutral	0.51	deleterious	-2	neutral	0.13	neutral	2.07	high_impact	-0.75	medium_impact	-1.45	low_impact	0.59	0.9	9.55	41.4	0.49	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7373	7373	A	T	MI.5025	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1470	490	M	I	atA/atT	2.83	0.97	0	benign	0	deleterious	0.02	neutral	3.05	neutral	0.67	neutral	-0.22	neutral_impact	-0.38	0.75	neutral	0.8	neutral	1.66	14.16	neutral	0.55	0.6	0.26	neutral	0.35	neutral	0.46	neutral	0.44	neutral	1	0.98	neutral	0.51	deleterious	-2	neutral	0.13	neutral	2.07	high_impact	-0.75	medium_impact	-1.45	low_impact	0.59	0.9	9.55	41.4	0.49	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7374	7374	A	G	MI.5026	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1471	491	N	D	Aac/Gac	-8.7	0	0	benign	0.14	deleterious	0.01	neutral	3	neutral	-0.25	neutral	-0.38	medium_impact	3.06	0.59	damaging	0.48	neutral	2.20	17.52	deleterious	0.57	0.6	0.38	neutral	0.38	neutral	0.46	neutral	0.47	neutral	1	0.99	deleterious	0.44	neutral	1	deleterious	0.25	neutral	-0.01	medium_impact	-0.92	medium_impact	1.73	medium_impact	0.47	0.9	10.92	16.37	0.46	N	0.76	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7374	7374	A	C	MI.5027	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1471	491	N	H	Aac/Cac	-8.7	0	0	possibly_damaging	0.8	neutral	0.14	neutral	2.93	neutral	-1.52	neutral	-0.57	medium_impact	2.8	0.56	damaging	0.57	neutral	3.11	22.50	deleterious	0.48	0.55	0.54	disease	0.32	neutral	0.33	neutral	0.51	disease	0	0.92	neutral	0.17	neutral	0	NA	0.61	deleterious	-1.32	low_impact	-0.25	medium_impact	1.49	medium_impact	0.52	0.9	10.92	16.37	0.5	P	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7374	7374	A	T	MI.5028	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1471	491	N	Y	Aac/Tac	-8.7	0	0	possibly_damaging	0.87	neutral	0.06	neutral	2.93	neutral	-2.38	neutral	-0.81	medium_impact	2.91	0.59	damaging	0.33	neutral	3.78	23.40	deleterious	0.32	0.55	0.63	disease	0.45	neutral	0.33	neutral	0.62	disease	2	0.97	neutral	0.1	neutral	0	NA	0.69	deleterious	-1.53	low_impact	-0.47	medium_impact	1.59	medium_impact	0.44	0.9	10.92	16.37	0.45	N	0.83	polymorphism	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7375	7375	A	G	MI.5029	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1472	491	N	S	aAc/aGc	6.75	1	0	benign	0	neutral	1	neutral	3.26	neutral	4.38	neutral	0.64	neutral_impact	0.25	0.65	neutral	0.69	neutral	-1.49	0.00	neutral	0.7	0.75	0.2	neutral	0.04	neutral	0.24	neutral	0.21	neutral	6	0	neutral	1	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	1.86	high_impact	-0.87	medium_impact	0.17	0.9	10.92	16.37	0.56	P	0.09	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8761	8761	A	G	MI.503	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	235	79	I	V	Att/Gtt	-2.88	0	0	probably_damaging	0.93	neutral	0.2	neutral	3.64	neutral	-1.71	neutral	-0.92	low_impact	1.86	0.92	neutral	0.47	neutral	2.95	22.10	deleterious	0.44	0.65	0.49	neutral	0.44	neutral	0.61	disease	0.5	neutral	0	0.95	neutral	0.14	neutral	-2	neutral	0.64	deleterious	-1.82	low_impact	-0.05	medium_impact	0.5	medium_impact	0.62	0.9	49.56	8.5	0.42	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7375	7375	A	C	MI.5030	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1472	491	N	T	aAc/aCc	6.75	1	0	benign	0.14	deleterious	0.04	neutral	3.09	neutral	-0.42	neutral	-0.1	medium_impact	2.19	0.58	damaging	0.39	neutral	1.63	14.02	neutral	0.45	0.55	0.2	neutral	0.21	neutral	0.45	neutral	0.37	neutral	3	0.96	neutral	0.45	neutral	1	deleterious	0.20	neutral	-0.01	medium_impact	-0.58	medium_impact	0.92	medium_impact	0.50	0.9	10.92	16.37	0.66	P	0.48	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7375	7375	A	T	MI.5031	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1472	491	N	I	aAc/aTc	6.75	1	0	possibly_damaging	0.83	deleterious	0.02	neutral	2.92	neutral	-1.94	neutral	-0.8	medium_impact	3.26	0.61	neutral	0.51	neutral	3.85	23.40	deleterious	0.29	0.55	0.52	disease	0.54	disease	0.44	neutral	0.49	neutral	0	0.99	deleterious	0.1	neutral	4	deleterious	0.64	deleterious	-1.4	low_impact	-0.75	medium_impact	1.91	medium_impact	0.28	0.9	10.92	16.37	0.59	P	0.84	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7376	7376	C	G	MI.5032	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1473	491	N	K	aaC/aaG	3.98	0.99	0	benign	0.39	deleterious	0.01	neutral	2.98	neutral	2.62	neutral	-0.36	high_impact	3.6	0.59	damaging	0.34	neutral	2.55	19.81	deleterious	0.64	0.65	0.29	neutral	0.44	neutral	0.48	neutral	0.48	neutral	0	0.99	deleterious	0.31	neutral	2	deleterious	0.46	deleterious	-0.57	medium_impact	-0.92	medium_impact	2.23	high_impact	0.62	0.9	10.92	16.37	0.49	P	0.76	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7376	7376	C	A	MI.5033	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1473	491	N	K	aaC/aaA	3.98	0.99	0	benign	0.39	deleterious	0.01	neutral	2.98	neutral	2.62	neutral	-0.36	high_impact	3.6	0.59	damaging	0.34	neutral	3.02	22.30	deleterious	0.64	0.65	0.29	neutral	0.44	neutral	0.48	neutral	0.48	neutral	0	0.99	deleterious	0.31	neutral	2	deleterious	0.46	deleterious	-0.57	medium_impact	-0.92	medium_impact	2.23	high_impact	0.62	0.9	10.92	16.37	0.48	P	0.76	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7377	7377	C	G	MI.5034	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1474	492	L	V	Ctg/Gtg	-3.4	0	0	benign	0	neutral	0.84	neutral	2.74	neutral	0.69	neutral	0.05	neutral_impact	0.8	0.73	neutral	0.86	neutral	1.97	16.04	deleterious	0.46	0.55	0.43	neutral	0.3	neutral	0.43	neutral	0.46	neutral	1	0.15	neutral	0.92	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.59	medium_impact	-0.36	medium_impact	0.77	0.9	9.36	29.6	0.31	N	0.21	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7377	7377	C	A	MI.5035	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1474	492	L	M	Ctg/Atg	-3.4	0	0	benign	0.06	neutral	0.13	neutral	2.67	neutral	-2.11	neutral	-0.19	low_impact	1.51	0.74	neutral	0.73	neutral	2.74	21.00	deleterious	0.31	0.55	0.64	disease	0.22	neutral	0.24	neutral	0.52	disease	0	0.86	neutral	0.54	deleterious	-6	neutral	0.17	neutral	0.37	medium_impact	-0.27	medium_impact	0.3	medium_impact	0.68	0.9	9.36	29.6	0.51	N	0.25	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7378	7378	T	C	MI.5036	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1475	492	L	P	cTg/cCg	-1.09	0	0	probably_damaging	0.99	neutral	0.42	neutral	2.67	deleterious	-4.57	neutral	-1.34	medium_impact	2.77	0.59	damaging	0.21	damaging	4.06	23.70	deleterious	0.16	0.55	0.88	disease	0.72	disease	0.34	neutral	0.67	disease	3	0.99	deleterious	0.22	neutral	1	deleterious	0.85	deleterious	-2.64	low_impact	0.12	medium_impact	1.46	medium_impact	0.56	0.9	9.36	29.6	0.3	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7378	7378	T	G	MI.5037	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1475	492	L	R	cTg/cGg	-1.09	0	0	probably_damaging	0.95	neutral	0.12	neutral	2.67	deleterious	-4.23	neutral	-1.21	medium_impact	2.48	0.6	neutral	0.11	damaging	4.31	24.00	deleterious	0.18	0.55	0.85	disease	0.73	disease	0.61	disease	0.74	disease	5	0.98	neutral	0.09	neutral	1	deleterious	0.83	deleterious	-1.96	low_impact	-0.29	medium_impact	1.19	medium_impact	0.68	0.9	9.36	29.6	0.26	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7378	7378	T	A	MI.5038	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1475	492	L	Q	cTg/cAg	-1.09	0	0	probably_damaging	0.95	neutral	0.09	neutral	2.65	deleterious	-4.35	neutral	-1.19	medium_impact	3.12	0.68	neutral	0.15	damaging	3.31	22.90	deleterious	0.2	0.55	0.85	disease	0.57	disease	0.32	neutral	0.6	disease	2	0.98	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-1.96	low_impact	-0.37	medium_impact	1.78	medium_impact	0.70	0.9	9.36	29.6	0.35	N	0.69	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7380	7380	G	A	MI.5039	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1477	493	E	K	Gag/Aag	-5.7	0	0	probably_damaging	1	deleterious	0	neutral	2.41	deleterious	-7.87	neutral	-1.19	high_impact	4.45	0.5	damaging	0.11	damaging	4.63	24.50	deleterious	0.42	0.55	0.77	disease	0.77	disease	0.62	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	3.01	high_impact	0.67	0.9	2.34	8.25	0.4	N	0.72	polymorphism	0.91	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8762	8762	T	A	MI.504	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	236	79	I	N	aTt/aAt	1.29	0.65	0	probably_damaging	1	deleterious	0	neutral	3.3	deleterious	-7.66	deleterious	-5.76	high_impact	3.77	0.84	neutral	0.39	neutral	4.15	23.80	deleterious	0.22	0.65	0.93	disease	0.82	disease	0.65	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.13	high_impact	0.40	0.9	49.56	8.5	0.38	N	0.99	polymorphism	0.99	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7380	7380	G	C	MI.5040	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1477	493	E	Q	Gag/Cag	-5.7	0	0	probably_damaging	0.99	deleterious	0	neutral	2.38	deleterious	-8.18	neutral	-0.89	high_impact	4.79	0.57	damaging	0.16	damaging	3.54	23.10	deleterious	0.43	0.55	0.77	disease	0.63	disease	0.59	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.64	low_impact	-1.48	low_impact	3.32	high_impact	0.79	0.9	2.34	8.25	0.62	P	0.66	polymorphism	0.98	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7381	7381	A	G	MI.5041	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1478	493	E	G	gAg/gGg	6.06	1	0	probably_damaging	1	deleterious	0	neutral	2.4	deleterious	-8.1	neutral	-2.09	high_impact	4.79	0.45	damaging	0.19	damaging	4.58	24.40	deleterious	0.3	0.55	0.78	disease	0.61	disease	0.56	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.50	0.9	2.34	8.25	0.69	P	0.67	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7381	7381	A	C	MI.5042	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1478	493	E	A	gAg/gCg	6.06	1	0	probably_damaging	1	deleterious	0.04	neutral	2.39	deleterious	-8.07	neutral	-1.79	high_impact	4.79	0.65	neutral	0.16	damaging	4.05	23.70	deleterious	0.23	0.55	0.78	disease	0.69	disease	0.6	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-0.58	medium_impact	3.32	high_impact	0.63	0.9	2.34	8.25	0.69	P	0.70	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7381	7381	A	T	MI.5043	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1478	493	E	V	gAg/gTg	6.06	1	0	probably_damaging	1	deleterious	0	neutral	2.34	deleterious	-9.33	neutral	-2.09	high_impact	4.79	0.51	damaging	0.14	damaging	4.61	24.40	deleterious	0.21	0.55	0.91	disease	0.81	disease	0.69	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.58	low_impact	-1.48	low_impact	3.32	high_impact	0.68	0.9	2.34	8.25	0.68	P	0.68	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7382	7382	G	C	MI.5044	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1479	493	E	D	gaG/gaC	8.59	1	0	probably_damaging	0.97	deleterious	0	neutral	2.44	deleterious	-6.85	neutral	-0.89	high_impact	3.64	0.55	damaging	0.15	damaging	3.86	23.50	deleterious	0.47	0.55	0.39	neutral	0.58	disease	0.42	neutral	0.46	neutral	1	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.18	low_impact	-1.48	low_impact	2.26	high_impact	0.84	0.9	2.34	8.25	0.51	P	0.70	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7382	7382	G	T	MI.5045	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1479	493	E	D	gaG/gaT	8.59	1	0	probably_damaging	0.97	deleterious	0	neutral	2.44	deleterious	-6.85	neutral	-0.89	high_impact	3.64	0.55	damaging	0.15	damaging	4.01	23.60	deleterious	0.47	0.55	0.39	neutral	0.58	disease	0.42	neutral	0.46	neutral	1	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.18	low_impact	-1.48	low_impact	2.26	high_impact	0.84	0.9	2.34	8.25	0.52	P	0.70	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7383	7383	T	C	MI.5046	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1480	494	W	R	Tga/Cga	-2.48	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-8.09	deleterious	-4.13	high_impact	4.42	0.65	neutral	0.05	damaging	3.80	23.40	deleterious	0.31	0.55	0.73	disease	0.84	disease	0.75	disease	0.78	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.25	0.9	2.14	6.66	0.43	N	0.94	disease_causing	0.93	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7383	7383	T	G	MI.5047	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1480	494	W	G	Tga/Gga	-2.48	0	0	probably_damaging	1	deleterious	0	neutral	2.62	deleterious	-7.99	deleterious	-3.84	high_impact	4.42	0.67	neutral	0.06	damaging	4.10	23.70	deleterious	0.27	0.55	0.72	disease	0.75	disease	0.72	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.58	low_impact	-1.48	low_impact	2.98	high_impact	0.27	0.9	2.14	6.66	0.4	N	0.90	disease_causing	0.98	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7384	7384	G	C	MI.5048	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1481	494	W	S	tGa/tCa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-7.83	deleterious	-4.12	high_impact	3.96	0.68	neutral	0.05	damaging	4.21	23.90	deleterious	0.23	0.55	0.6	disease	0.87	disease	0.7	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	2.56	high_impact	0.20	0.9	2.14	6.66	0.41	N	0.88	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7384	7384	G	T	MI.5049	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1481	494	W	L	tGa/tTa	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.7	deleterious	-6.41	deleterious	-3.83	high_impact	4.07	0.71	neutral	0.04	damaging	4.48	24.20	deleterious	0.23	0.55	0.54	disease	0.77	disease	0.67	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.66	high_impact	0.22	0.9	2.14	6.66	0.47	N	0.95	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8762	8762	T	C	MI.505	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	236	79	I	T	aTt/aCt	1.29	0.65	0	probably_damaging	0.99	deleterious	0	neutral	3.34	deleterious	-5.51	deleterious	-3.88	medium_impact	3.42	0.89	neutral	0.43	neutral	3.18	22.70	deleterious	0.4	0.65	0.78	disease	0.6	disease	0.62	disease	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.77	deleterious	-2.65	low_impact	-1.4	low_impact	1.83	medium_impact	0.53	0.9	49.56	8.5	0.44	N	0.70	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7385	7385	A	C	MI.5050	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1482	494	W	C	tgA/tgC	7.21	1	0.01	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-9.38	deleterious	-3.84	high_impact	4.76	0.63	neutral	0.04	damaging	4.20	23.90	deleterious	0.26	0.55	0.84	disease	0.83	disease	0.78	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.17	0.9	2.14	6.66	0.66	P	0.88	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7385	7385	A	T	MI.5051	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1482	494	W	C	tgA/tgT	7.21	1	0.01	probably_damaging	1	deleterious	0	neutral	2.58	deleterious	-9.38	deleterious	-3.84	high_impact	4.76	0.63	neutral	0.04	damaging	4.32	24.00	deleterious	0.26	0.55	0.84	disease	0.83	disease	0.78	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.3	high_impact	0.17	0.9	2.14	6.66	0.66	P	0.88	disease_causing	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7386	7386	C	A	MI.5052	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1483	495	L	M	Cta/Ata	2.6	0.98	0	possibly_damaging	0.79	neutral	0.11	neutral	2.83	neutral	-1.4	neutral	0.06	low_impact	1.9	0.72	neutral	0.92	neutral	2.62	20.30	deleterious	0.29	0.55	0.42	neutral	0.08	neutral	0.17	neutral	0.32	neutral	4	0.93	neutral	0.16	neutral	-3	neutral	0.53	deleterious	-1.3	low_impact	-0.31	medium_impact	0.66	medium_impact	0.73	0.9	8.38	10.14	0.64	P	0.55	disease_causing	0.9	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7386	7386	C	G	MI.5053	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1483	495	L	V	Cta/Gta	2.6	0.98	0	benign	0.05	neutral	0.16	neutral	2.87	neutral	-0.26	neutral	-0.16	medium_impact	3.23	0.71	neutral	0.21	damaging	2.35	18.51	deleterious	0.39	0.55	0.25	neutral	0.2	neutral	0.33	neutral	0.36	neutral	3	0.83	neutral	0.56	deleterious	-3	neutral	0.10	neutral	0.45	medium_impact	-0.21	medium_impact	1.88	medium_impact	0.54	0.9	8.38	10.14	0.65	P	0.64	disease_causing	0.92	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7387	7387	T	G	MI.5054	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1484	495	L	R	cTa/cGa	-0.86	0.02	0	possibly_damaging	0.88	neutral	0.05	neutral	2.82	neutral	1.58	neutral	-0.44	high_impact	4.26	0.56	damaging	0.12	damaging	3.22	22.70	deleterious	0.24	0.55	0.43	neutral	0.56	disease	0.46	neutral	0.49	neutral	0	0.98	neutral	0.09	neutral	1	deleterious	0.70	deleterious	-1.57	low_impact	-0.52	medium_impact	2.83	high_impact	0.55	0.9	8.38	10.14	0.43	N	0.88	polymorphism	0.86	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7387	7387	T	C	MI.5055	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1484	495	L	P	cTa/cCa	-0.86	0.02	0	probably_damaging	0.96	deleterious	0.03	neutral	2.83	neutral	-0.87	neutral	-0.72	high_impact	3.92	0.55	damaging	0.13	damaging	4.10	23.70	deleterious	0.17	0.55	0.58	disease	0.64	disease	0.29	neutral	0.49	neutral	0	0.99	deleterious	0.04	neutral	6	deleterious	0.76	deleterious	-2.06	low_impact	-0.65	medium_impact	2.52	high_impact	0.36	0.9	8.38	10.14	0.39	N	0.86	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7387	7387	T	A	MI.5056	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1484	495	L	Q	cTa/cAa	-0.86	0.02	0	probably_damaging	0.91	neutral	0.12	neutral	2.84	neutral	0.69	neutral	-0.27	medium_impact	2.65	0.68	neutral	0.23	damaging	3.00	22.20	deleterious	0.25	0.55	0.34	neutral	0.31	neutral	0.24	neutral	0.47	neutral	1	0.96	neutral	0.11	neutral	1	deleterious	0.64	deleterious	-1.7	low_impact	-0.29	medium_impact	1.35	medium_impact	0.57	0.9	8.38	10.14	0.47	N	0.84	polymorphism	0.88	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7389	7389	T	C	MI.5057	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1486	496	Y	H	Tat/Cat	-11.24	0	0.01	benign	0	neutral	1	neutral	3.02	neutral	2.06	neutral	0.5	neutral_impact	-2.33	0.76	neutral	0.98	neutral	-0.96	0.02	neutral	0.64	0.65	0.2	neutral	0.13	neutral	0.19	neutral	0.27	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	1.86	high_impact	-3.25	low_impact	0.27	0.9	11.5	36.42	0.37	N	0.03	polymorphism	1	0.00	rs9783095	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7389	7389	T	G	MI.5058	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1486	496	Y	D	Tat/Gat	-11.24	0	0.01	benign	0.02	neutral	0.1	neutral	2.99	neutral	1.69	neutral	-0.09	neutral_impact	0.31	0.59	damaging	0.36	neutral	0.94	10.30	neutral	0.42	0.55	0.24	neutral	0.48	neutral	0.45	neutral	0.45	neutral	1	0.9	neutral	0.54	deleterious	-6	neutral	0.12	neutral	0.83	medium_impact	-0.34	medium_impact	-0.81	medium_impact	0.32	0.9	11.5	36.42	0.46	N	0.55	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7389	7389	T	A	MI.5059	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1486	496	Y	N	Tat/Aat	-11.24	0	0.01	benign	0	neutral	0.34	neutral	3.01	neutral	2.1	neutral	0.14	neutral_impact	-1.66	0.85	neutral	0.98	neutral	0.61	8.21	deleterious	0.42	0.55	0.19	neutral	0.37	neutral	0.25	neutral	0.45	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.03	medium_impact	-2.63	low_impact	0.19	0.9	11.5	36.42	0.37	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8762	8762	T	G	MI.506	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	236	79	I	S	aTt/aGt	1.29	0.65	0	probably_damaging	0.99	deleterious	0	neutral	3.3	deleterious	-5.88	deleterious	-4.8	medium_impact	3.21	0.81	neutral	0.46	neutral	4.11	23.70	deleterious	0.21	0.65	0.56	disease	0.81	disease	0.62	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-2.65	low_impact	-1.4	low_impact	1.65	medium_impact	0.37	0.9	49.56	8.5	0.33	N	0.89	polymorphism	0.99	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7390	7390	A	C	MI.5060	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1487	496	Y	S	tAt/tCt	0.29	0.02	0	benign	0.02	neutral	0.16	neutral	3	neutral	1.98	neutral	-0.04	neutral_impact	-0.28	0.61	neutral	0.56	neutral	0.72	8.99	deleterious	0.29	0.55	0.17	neutral	0.33	neutral	0.29	neutral	0.45	neutral	1	0.83	neutral	0.57	deleterious	-6	neutral	0.12	neutral	0.83	medium_impact	-0.21	medium_impact	-1.36	low_impact	0.30	0.9	11.5	36.42	0.51	N	0.36	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7390	7390	A	T	MI.5061	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1487	496	Y	F	tAt/tTt	0.29	0.02	0	benign	0.05	neutral	0.26	neutral	3	neutral	-0.63	neutral	-0.57	neutral_impact	0.48	0.65	neutral	0.64	neutral	0.20	4.66	deleterious	0.39	0.55	0.27	neutral	0.27	neutral	0.32	neutral	0.43	neutral	1	0.72	neutral	0.61	deleterious	-6	neutral	0.13	neutral	0.45	medium_impact	-0.06	medium_impact	-0.66	medium_impact	0.26	0.9	11.5	36.42	0.51	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7390	7390	A	G	MI.5062	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1487	496	Y	C	tAt/tGt	0.29	0.02	0	possibly_damaging	0.48	neutral	0.07	neutral	2.96	neutral	-1.41	neutral	-0.78	low_impact	0.94	0.61	neutral	0.38	neutral	2.14	17.11	deleterious	0.37	0.55	0.25	neutral	0.57	disease	0.29	neutral	0.49	neutral	0	0.92	neutral	0.3	neutral	-3	neutral	0.44	deleterious	-0.72	medium_impact	-0.43	medium_impact	-0.23	medium_impact	0.12	0.9	11.5	36.42	0.46	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7392	7392	G	C	MI.5063	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1489	497	G	R	Gga/Cga	-1.78	0	0	probably_damaging	1	neutral	0.06	neutral	3	neutral	-0.08	neutral	-0.06	medium_impact	2.29	0.61	neutral	0.09	damaging	2.61	20.30	deleterious	0.37	0.55	0.25	neutral	0.57	disease	0.35	neutral	0.5	disease	0	1	deleterious	0.03	neutral	1	deleterious	0.67	deleterious	-3.58	low_impact	-0.47	medium_impact	1.02	medium_impact	0.72	0.9	2.92	6.67	0.37	N	0.90	disease_causing	0.93	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7392	7392	G	T	MI.5064	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1489	497	G	W	Gga/Tga	-1.78	0	0	probably_damaging	1	deleterious	0.01	neutral	2.96	deleterious	-3.29	neutral	-0.93	medium_impact	2.63	0.63	neutral	0.1	damaging	3.44	23.00	deleterious	0.22	0.55	0.79	disease	0.6	disease	0.52	disease	0.63	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-0.92	medium_impact	1.33	medium_impact	0.42	0.9	2.92	6.67	0.29	N	0.83	disease_causing	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7393	7393	G	C	MI.5065	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1490	497	G	A	gGa/gCa	6.06	1	0	probably_damaging	1	neutral	0.06	neutral	3.06	neutral	0.64	neutral	-0.36	medium_impact	2.04	0.68	neutral	0.17	damaging	1.59	13.79	neutral	0.41	0.55	0.17	neutral	0.27	neutral	0.27	neutral	0.43	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.62	deleterious	-3.58	low_impact	-0.47	medium_impact	0.79	medium_impact	0.61	0.9	2.92	6.67	0.58	P	0.66	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7393	7393	G	A	MI.5066	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1490	497	G	E	gGa/gAa	6.06	1	0	probably_damaging	1	neutral	0.09	neutral	3	neutral	0.88	neutral	-0.1	medium_impact	2.17	0.65	neutral	0.1	damaging	2.50	19.48	deleterious	0.4	0.55	0.15	neutral	0.51	disease	0.44	neutral	0.41	neutral	2	1	deleterious	0.05	neutral	1	deleterious	0.63	deleterious	-3.58	low_impact	-0.37	medium_impact	0.91	medium_impact	0.53	0.9	2.92	6.67	0.52	P	0.92	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7393	7393	G	T	MI.5067	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1490	497	G	V	gGa/gTa	6.06	1	0	probably_damaging	1	neutral	0.07	neutral	3.04	neutral	-0.49	neutral	-0.7	medium_impact	2.42	0.6	neutral	0.1	damaging	2.36	18.58	deleterious	0.37	0.55	0.38	neutral	0.43	neutral	0.38	neutral	0.46	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.67	deleterious	-3.58	low_impact	-0.43	medium_impact	1.14	medium_impact	0.43	0.9	2.92	6.67	0.54	P	0.92	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7395	7395	T	A	MI.5068	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1492	498	C	S	Tgc/Agc	-4.55	0	0	benign	0	neutral	0.55	neutral	3.19	neutral	-0.6	neutral	-0.18	low_impact	0.95	0.67	neutral	0.57	neutral	0.09	3.54	deleterious	0.43	0.55	0.24	neutral	0.12	neutral	0.41	neutral	0.3	neutral	4	0.45	neutral	0.78	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.24	medium_impact	-0.22	medium_impact	0.44	0.9	7.6	41.15	0.39	N	0.81	polymorphism	0.99	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7395	7395	T	C	MI.5069	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1492	498	C	R	Tgc/Cgc	-4.55	0	0	benign	0.31	neutral	0.1	neutral	3.02	neutral	-1.59	neutral	-0.51	medium_impact	2.8	0.58	damaging	0.34	neutral	0.87	9.91	deleterious	0.29	0.55	0.29	neutral	0.57	disease	0.63	disease	0.73	disease	5	0.88	neutral	0.4	neutral	-3	neutral	0.50	deleterious	-0.43	medium_impact	-0.34	medium_impact	1.49	medium_impact	0.20	0.9	7.6	41.15	0.39	N	0.80	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8763	8763	T	G	MI.507	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	237	79	I	M	atT/atG	5.68	0.95	0	probably_damaging	1	deleterious	0.04	neutral	3.34	deleterious	-5.44	neutral	-1.76	medium_impact	2.73	0.84	neutral	0.42	neutral	3.31	22.90	deleterious	0.34	0.65	0.85	disease	0.64	disease	0.64	disease	0.72	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.6	low_impact	-0.49	medium_impact	1.24	medium_impact	0.76	0.9	49.56	8.5	0.5	N	0.80	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7395	7395	T	G	MI.5070	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1492	498	C	G	Tgc/Ggc	-4.55	0	0	benign	0.09	neutral	0.26	neutral	3.02	neutral	-1.92	neutral	-0.75	medium_impact	2.8	0.63	neutral	0.48	neutral	0.44	6.93	deleterious	0.29	0.55	0.36	neutral	0.38	neutral	0.57	disease	0.48	neutral	0	0.71	neutral	0.59	deleterious	-3	neutral	0.20	neutral	0.19	medium_impact	-0.06	medium_impact	1.49	medium_impact	0.32	0.9	7.6	41.15	0.45	N	0.88	polymorphism	0.98	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7396	7396	G	C	MI.5071	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1493	498	C	S	tGc/tCc	7.44	1	0	benign	0	neutral	0.55	neutral	3.19	neutral	-0.6	neutral	-0.18	low_impact	0.95	0.67	neutral	0.57	neutral	-0.34	0.54	neutral	0.43	0.55	0.24	neutral	0.12	neutral	0.41	neutral	0.3	neutral	4	0.45	neutral	0.78	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.24	medium_impact	-0.22	medium_impact	0.44	0.9	7.6	41.15	0.59	P	0.81	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7396	7396	G	A	MI.5072	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1493	498	C	Y	tGc/tAc	7.44	1	0	possibly_damaging	0.65	neutral	0.53	neutral	3.08	neutral	2.16	neutral	0.06	neutral_impact	0.7	0.58	damaging	0.56	neutral	1.35	12.54	neutral	0.37	0.55	0.46	neutral	0.32	neutral	0.35	neutral	0.45	neutral	1	0.62	neutral	0.44	neutral	-3	neutral	0.56	deleterious	-1.01	low_impact	0.22	medium_impact	-0.45	medium_impact	0.50	0.9	7.6	41.15	0.55	P	0.90	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7396	7396	G	T	MI.5073	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1493	498	C	F	tGc/tTc	7.44	1	0	possibly_damaging	0.57	neutral	0.35	neutral	3.06	neutral	-0.46	neutral	0.21	low_impact	0.96	0.6	damaging	0.62	neutral	1.65	14.11	neutral	0.36	0.55	0.44	neutral	0.34	neutral	0.32	neutral	0.46	neutral	1	0.66	neutral	0.39	neutral	-3	neutral	0.53	deleterious	-0.87	medium_impact	0.04	medium_impact	-0.21	medium_impact	0.42	0.9	7.6	41.15	0.62	P	0.97	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7397	7397	C	A	MI.5074	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1494	498	C	W	tgC/tgA	6.06	1	0	possibly_damaging	0.8	neutral	0.05	neutral	2.99	deleterious	-3.46	neutral	-0.3	medium_impact	3.15	0.61	neutral	0.37	neutral	3.48	23.10	deleterious	0.31	0.55	0.67	disease	0.6	disease	0.47	neutral	0.5	neutral	0	0.97	neutral	0.13	neutral	0	NA	0.69	deleterious	-1.32	low_impact	-0.52	medium_impact	1.81	medium_impact	0.26	0.9	7.6	41.15	0.6	P	0.93	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7397	7397	C	G	MI.5075	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1494	498	C	W	tgC/tgG	6.06	1	0	possibly_damaging	0.8	neutral	0.05	neutral	2.99	deleterious	-3.46	neutral	-0.3	medium_impact	3.15	0.61	neutral	0.37	neutral	3.21	22.70	deleterious	0.31	0.55	0.67	disease	0.6	disease	0.47	neutral	0.5	neutral	0	0.97	neutral	0.13	neutral	0	NA	0.69	deleterious	-1.32	low_impact	-0.52	medium_impact	1.81	medium_impact	0.26	0.9	7.6	41.15	0.59	P	0.93	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7398	7398	C	T	MI.5076	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1495	499	P	S	Ccc/Tcc	-2.48	0	0	probably_damaging	1	deleterious	0.01	neutral	2.27	deleterious	-5.61	neutral	-2.16	medium_impact	3.4	0.72	neutral	0.05	damaging	4.12	23.80	deleterious	0.35	0.55	0.3	neutral	0.72	disease	0.67	disease	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-3.58	low_impact	-0.92	medium_impact	2.04	high_impact	0.21	0.9	NA	NA	0.28	N	0.84	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7398	7398	C	G	MI.5077	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1495	499	P	A	Ccc/Gcc	-2.48	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.28	deleterious	-5.67	neutral	-2.17	high_impact	4.38	0.71	neutral	0.06	damaging	3.23	22.80	deleterious	0.31	0.55	0.48	neutral	0.64	disease	0.75	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.76	deleterious	-2.64	low_impact	-0.92	medium_impact	2.95	high_impact	0.56	0.9	NA	NA	0.4	N	0.76	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7398	7398	C	A	MI.5078	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1495	499	P	T	Ccc/Acc	-2.48	0	0	probably_damaging	1	deleterious	0	neutral	2.28	deleterious	-6.2	neutral	-2.15	high_impact	4.04	0.71	neutral	0.05	damaging	3.86	23.50	deleterious	0.33	0.55	0.59	disease	0.8	disease	0.74	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.58	low_impact	-1.48	low_impact	2.63	high_impact	0.47	0.9	NA	NA	0.33	N	0.82	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7399	7399	C	G	MI.5079	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1496	499	P	R	cCc/cGc	4.44	0.99	0	probably_damaging	1	deleterious	0	neutral	2.26	deleterious	-6.32	neutral	-2.44	high_impact	4.38	0.71	neutral	0.04	damaging	3.84	23.40	deleterious	0.28	0.55	0.86	disease	0.82	disease	0.8	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.58	low_impact	-1.48	low_impact	2.95	high_impact	0.49	0.9	NA	NA	0.5	P	0.87	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8763	8763	T	A	MI.508	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	237	79	I	M	atT/atA	5.68	0.95	0	probably_damaging	1	deleterious	0.04	neutral	3.34	deleterious	-5.44	neutral	-1.76	medium_impact	2.73	0.84	neutral	0.42	neutral	3.60	23.20	deleterious	0.34	0.65	0.85	disease	0.64	disease	0.64	disease	0.72	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-3.6	low_impact	-0.49	medium_impact	1.24	medium_impact	0.76	0.9	49.56	8.5	0.52	N	0.80	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7399	7399	C	A	MI.5080	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1496	499	P	H	cCc/cAc	4.44	0.99	0	probably_damaging	1	deleterious	0.03	neutral	2.24	deleterious	-7.11	neutral	-2.41	high_impact	4.73	0.72	neutral	0.04	damaging	4.22	23.90	deleterious	0.3	0.55	0.92	disease	0.79	disease	0.78	disease	0.87	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-0.65	medium_impact	3.27	high_impact	0.45	0.9	NA	NA	0.67	P	0.82	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7399	7399	C	T	MI.5081	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1496	499	P	L	cCc/cTc	4.44	0.99	0	probably_damaging	1	deleterious	0	neutral	2.31	deleterious	-7.04	deleterious	-2.62	high_impact	4.73	0.71	neutral	0.04	damaging	4.62	24.50	deleterious	0.3	0.55	0.85	disease	0.8	disease	0.73	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.58	low_impact	-1.48	low_impact	3.27	high_impact	0.65	0.9	NA	NA	0.68	P	0.89	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7401	7401	C	G	MI.5082	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1498	500	P	A	Cca/Gca	-5.47	0	0	probably_damaging	0.99	deleterious	0.02	neutral	2.68	deleterious	-5.86	neutral	-1.94	high_impact	3.8	0.7	neutral	0.17	damaging	3.21	22.70	deleterious	0.29	0.55	0.27	neutral	0.6	disease	0.55	disease	0.45	neutral	1	1	deleterious	0.02	neutral	6	deleterious	0.71	deleterious	-2.64	low_impact	-0.75	medium_impact	2.41	high_impact	0.68	0.9	NA	NA	0.38	N	0.76	polymorphism	0.94	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7401	7401	C	A	MI.5083	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1498	500	P	T	Cca/Aca	-5.47	0	0	probably_damaging	1	deleterious	0.01	neutral	2.64	deleterious	-6.39	neutral	-1.97	high_impact	4.14	0.69	neutral	0.12	damaging	3.90	23.50	deleterious	0.3	0.55	0.39	neutral	0.79	disease	0.35	neutral	0.6	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	2.72	high_impact	0.58	0.9	NA	NA	0.35	N	0.82	polymorphism	0.91	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7401	7401	C	T	MI.5084	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1498	500	P	S	Cca/Tca	-5.47	0	0	probably_damaging	1	deleterious	0.02	neutral	2.65	deleterious	-5.8	neutral	-1.98	medium_impact	3.19	0.63	neutral	0.14	damaging	4.10	23.70	deleterious	0.33	0.55	0.38	neutral	0.69	disease	0.37	neutral	0.51	disease	0	1	deleterious	0.01	neutral	5	deleterious	0.75	deleterious	-3.58	low_impact	-0.75	medium_impact	1.85	medium_impact	0.28	0.9	NA	NA	0.35	N	0.84	polymorphism	0.9	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7402	7402	C	G	MI.5085	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1499	500	P	R	cCa/cGa	5.6	1	0	probably_damaging	1	deleterious	0	neutral	2.63	deleterious	-6.52	neutral	-2.26	high_impact	4.69	0.7	neutral	0.08	damaging	3.76	23.40	deleterious	0.26	0.55	0.44	neutral	0.8	disease	0.71	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	3.23	high_impact	0.51	0.9	NA	NA	0.55	P	0.87	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7402	7402	C	A	MI.5086	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1499	500	P	Q	cCa/cAa	5.6	1	0	probably_damaging	1	deleterious	0	neutral	2.61	deleterious	-6.14	neutral	-2.01	high_impact	4.34	0.71	neutral	0.09	damaging	4.22	23.90	deleterious	0.22	0.55	0.41	neutral	0.78	disease	0.66	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-1.48	low_impact	2.91	high_impact	0.41	0.9	NA	NA	0.44	N	0.83	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7402	7402	C	T	MI.5087	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1499	500	P	L	cCa/cTa	5.6	1	0	probably_damaging	1	neutral	0.1	neutral	2.7	deleterious	-7.23	neutral	-2.44	medium_impact	3.27	0.55	damaging	0.11	damaging	3.48	23.10	deleterious	0.35	0.55	0.54	disease	0.76	disease	0.55	disease	0.54	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.58	low_impact	-0.34	medium_impact	1.92	medium_impact	0.70	0.9	NA	NA	0.47	N	0.89	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7404	7404	C	G	MI.5088	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1501	501	P	A	Ccc/Gcc	-10.55	0	0	benign	0	neutral	0.62	neutral	2.98	neutral	2.25	neutral	0.47	neutral_impact	0.5	0.67	neutral	0.3	neutral	-1.34	0.00	neutral	0.25	0.55	0.23	neutral	0.07	neutral	0.16	neutral	0.24	neutral	5	0.37	neutral	0.81	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.31	medium_impact	-0.64	medium_impact	0.53	0.9	4.48	8	0.47	N	0.76	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7404	7404	C	T	MI.5089	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1501	501	P	S	Ccc/Tcc	-10.55	0	0	benign	0.28	neutral	0.36	neutral	2.89	neutral	3.23	neutral	0.32	neutral_impact	0.66	0.65	neutral	0.32	neutral	0.01	2.73	deleterious	0.32	0.55	0.19	neutral	0.14	neutral	0.16	neutral	0.26	neutral	5	0.56	neutral	0.54	deleterious	-6	neutral	0.33	neutral	-0.37	medium_impact	0.05	medium_impact	-0.49	medium_impact	0.31	0.9	4.48	8	0.51	N	0.84	polymorphism	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8764	8764	G	C	MI.509	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	238	80	A	P	Gcc/Ccc	-7.51	0	0.02	possibly_damaging	0.55	deleterious	0.01	neutral	4.35	neutral	-2.79	deleterious	-2.62	low_impact	1.5	0.79	neutral	0.4	neutral	3.28	22.80	deleterious	0.17	0.65	0.77	disease	0.77	disease	0.59	disease	0.75	disease	5	0.99	deleterious	0.23	neutral	1	deleterious	0.67	deleterious	-0.84	medium_impact	-0.84	medium_impact	0.19	medium_impact	0.75	0.9	25.66	23.52	0.27	N	0.88	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7404	7404	C	A	MI.5090	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1501	501	P	T	Ccc/Acc	-10.55	0	0	benign	0.28	neutral	0.15	neutral	2.87	neutral	2.11	neutral	0.07	low_impact	1.1	0.67	neutral	0.18	damaging	0.64	8.41	deleterious	0.23	0.55	0.33	neutral	0.25	neutral	0.34	neutral	0.45	neutral	1	0.82	neutral	0.44	neutral	-6	neutral	0.28	neutral	-0.37	medium_impact	-0.23	medium_impact	-0.08	medium_impact	0.50	0.9	4.48	8	0.43	N	0.82	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7405	7405	C	A	MI.5091	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1502	501	P	H	cCc/cAc	3.52	0.98	0	probably_damaging	0.93	neutral	0.06	neutral	2.83	neutral	0.05	neutral	-0.39	medium_impact	2.46	0.67	neutral	0.12	damaging	3.10	22.50	deleterious	0.25	0.55	0.45	neutral	0.3	neutral	0.28	neutral	0.47	neutral	1	0.98	deleterious	0.07	neutral	1	deleterious	0.65	deleterious	-1.81	low_impact	-0.47	medium_impact	1.17	medium_impact	0.46	0.9	4.48	8	0.52	P	0.82	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7405	7405	C	T	MI.5092	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1502	501	P	L	cCc/cTc	3.52	0.98	0	possibly_damaging	0.5	neutral	0.29	neutral	2.96	neutral	5.07	neutral	-0.22	low_impact	0.98	0.64	neutral	0.1	damaging	1.70	14.43	neutral	0.28	0.55	0.35	neutral	0.34	neutral	0.36	neutral	0.45	neutral	1	0.68	neutral	0.4	neutral	-3	neutral	0.48	deleterious	-0.76	medium_impact	-0.02	medium_impact	-0.19	medium_impact	0.74	0.9	4.48	8	0.49	N	0.89	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7405	7405	C	G	MI.5093	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1502	501	P	R	cCc/cGc	3.52	0.98	0	possibly_damaging	0.88	neutral	0.12	neutral	2.85	neutral	0.61	neutral	-0.25	medium_impact	3.36	0.64	neutral	0.09	damaging	2.23	17.69	deleterious	0.25	0.55	0.32	neutral	0.43	neutral	0.46	neutral	0.49	neutral	0	0.95	neutral	0.12	neutral	0	NA	0.61	deleterious	-1.57	low_impact	-0.29	medium_impact	2	high_impact	0.54	0.9	4.48	8	0.5	N	0.87	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7407	7407	T	C	MI.5094	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1504	502	Y	H	Tac/Cac	-5.01	0	0	benign	0.01	neutral	0.55	neutral	2.98	neutral	1.1	neutral	0.29	low_impact	1.16	0.72	neutral	0.77	neutral	0.04	2.96	deleterious	0.64	0.65	0.19	neutral	0.29	neutral	0.26	neutral	0.43	neutral	1	0.44	neutral	0.77	deleterious	-6	neutral	0.11	neutral	1.12	medium_impact	0.24	medium_impact	-0.03	medium_impact	0.27	0.9	11.89	12.5	0.35	N	0.64	polymorphism	1	0.00	rs201121626	.	.	.	.	.	COSM1138404	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7407	7407	T	A	MI.5095	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1504	502	Y	N	Tac/Aac	-5.01	0	0	benign	0.25	neutral	0.27	neutral	3	neutral	2.71	neutral	0.2	low_impact	0.98	0.64	neutral	0.48	neutral	1.06	10.98	neutral	0.43	0.55	0.3	neutral	0.5	disease	0.37	neutral	0.46	neutral	1	0.67	neutral	0.51	deleterious	-6	neutral	0.29	neutral	-0.31	medium_impact	-0.05	medium_impact	-0.19	medium_impact	0.31	0.9	11.89	12.5	0.41	N	0.95	polymorphism	0.95	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7407	7407	T	G	MI.5096	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1504	502	Y	D	Tac/Gac	-5.01	0	0	benign	0.32	neutral	0.2	neutral	2.98	neutral	3.6	neutral	0.63	low_impact	1.22	0.69	neutral	0.64	neutral	2.18	17.38	deleterious	0.44	0.55	0.31	neutral	0.43	neutral	0.45	neutral	0.46	neutral	1	0.76	neutral	0.44	neutral	-6	neutral	0.44	deleterious	-0.45	medium_impact	-0.14	medium_impact	0.03	medium_impact	0.39	0.9	11.89	12.5	0.41	N	0.98	polymorphism	0.96	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7408	7408	A	C	MI.5097	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1505	502	Y	S	tAc/tCc	1.91	0.95	0	benign	0.16	neutral	0.33	neutral	3.02	neutral	2.36	neutral	0.14	low_impact	1.06	0.64	neutral	0.52	neutral	1.20	11.73	neutral	0.32	0.55	0.16	neutral	0.41	neutral	0.37	neutral	0.44	neutral	1	0.61	neutral	0.59	deleterious	-6	neutral	0.32	neutral	-0.08	medium_impact	0.02	medium_impact	-0.12	medium_impact	0.27	0.9	11.89	12.5	0.44	N	0.90	polymorphism	0.57	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7408	7408	A	T	MI.5098	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1505	502	Y	F	tAc/tTc	1.91	0.95	0	benign	0	neutral	0.61	neutral	3.03	neutral	-0.51	neutral	-0.19	neutral_impact	0.72	0.75	neutral	0.97	neutral	0.15	4.14	deleterious	0.38	0.55	0.34	neutral	0.17	neutral	0.23	neutral	0.28	neutral	4	0.38	neutral	0.81	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.3	medium_impact	-0.43	medium_impact	0.35	0.9	11.89	12.5	0.43	N	0.50	polymorphism	0.94	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7408	7408	A	G	MI.5099	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1505	502	Y	C	tAc/tGc	1.91	0.95	0	possibly_damaging	0.81	neutral	0.14	neutral	2.93	neutral	-1.37	neutral	-0.62	medium_impact	2.82	0.64	neutral	0.32	neutral	2.99	22.20	deleterious	0.37	0.55	0.63	disease	0.65	disease	0.4	neutral	0.51	disease	0	0.92	neutral	0.17	neutral	0	NA	0.65	deleterious	-1.35	low_impact	-0.25	medium_impact	1.51	medium_impact	0.11	0.9	11.89	12.5	0.42	N	0.89	disease_causing	0.55	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8548	8548	T	C	MI.51	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	22	8	S	P	Tca/Cca	-0.1	0.83	0	benign	0	neutral	0.16	neutral	4.59	neutral	-1.94	neutral	-1.27	low_impact	1.84	0.95	neutral	0.86	neutral	0.64	8.41	deleterious	0.22	0.65	0.8	disease	0.84	disease	0.57	disease	0.67	disease	3	0.84	neutral	0.58	deleterious	-6	neutral	0.33	neutral	2.09	high_impact	-0.12	medium_impact	0.48	medium_impact	0.74	0.9	21.24	17.86	0.3	N	0.05	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8764	8764	G	A	MI.510	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	238	80	A	T	Gcc/Acc	-7.51	0	0.02	benign	0.01	neutral	0.05	neutral	4.37	neutral	-1.01	neutral	-1.22	neutral_impact	0.12	0.98	neutral	0.83	neutral	0.96	10.43	neutral	0.5	0.65	0.41	neutral	0.22	neutral	0.24	neutral	0.39	neutral	2	0.95	neutral	0.52	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	-0.43	medium_impact	-1	medium_impact	0.62	0.9	25.66	23.52	0.53	N	0.04	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7410	7410	C	G	MI.5100	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1507	503	H	D	Cac/Gac	-2.94	0	0	probably_damaging	0.97	deleterious	0.04	neutral	2.69	deleterious	-4.06	neutral	-2.36	high_impact	4.37	0.65	neutral	0.12	damaging	3.99	23.60	deleterious	0.28	0.55	0.53	disease	0.8	disease	0.81	disease	0.76	disease	5	0.99	deleterious	0.04	neutral	6	deleterious	0.75	deleterious	-2.18	low_impact	-0.58	medium_impact	2.94	high_impact	0.45	0.9	NA	NA	0.48	N	0.97	disease_causing	0.98	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7410	7410	C	A	MI.5101	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1507	503	H	N	Cac/Aac	-2.94	0	0	probably_damaging	0.95	deleterious	0.03	neutral	2.68	deleterious	-4.8	neutral	-1.84	high_impact	4.71	0.61	neutral	0.11	damaging	4.14	23.80	deleterious	0.55	0.6	0.51	disease	0.82	disease	0.76	disease	0.76	disease	5	0.99	deleterious	0.04	neutral	6	deleterious	0.74	deleterious	-1.96	low_impact	-0.65	medium_impact	3.25	high_impact	0.45	0.9	NA	NA	0.67	P	0.87	disease_causing	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7410	7410	C	T	MI.5102	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1507	503	H	Y	Cac/Tac	-2.94	0	0	probably_damaging	0.93	deleterious	0	neutral	2.76	deleterious	-6.83	neutral	-1.58	high_impact	4.37	0.66	neutral	0.11	damaging	3.82	23.40	deleterious	0.54	0.6	0.2	neutral	0.83	disease	0.79	disease	0.77	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.70	deleterious	-1.81	low_impact	-1.48	low_impact	2.94	high_impact	0.32	0.9	NA	NA	0.49	N	0.72	disease_causing	0.96	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7411	7411	A	G	MI.5103	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1508	503	H	R	cAc/cGc	5.6	1	0	probably_damaging	0.93	deleterious	0	neutral	2.69	deleterious	-5.14	neutral	-2.1	high_impact	4.16	0.65	neutral	0.12	damaging	3.11	22.50	deleterious	0.55	0.6	0.49	neutral	0.82	disease	0.76	disease	0.76	disease	5	1	deleterious	0.04	neutral	6	deleterious	0.77	deleterious	-1.81	low_impact	-1.48	low_impact	2.74	high_impact	0.37	0.9	NA	NA	0.5	P	0.85	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7411	7411	A	C	MI.5104	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1508	503	H	P	cAc/cCc	5.6	1	0	probably_damaging	0.98	deleterious	0	neutral	2.66	deleterious	-6.41	deleterious	-2.63	high_impact	4.71	0.59	damaging	0.13	damaging	3.38	22.90	deleterious	0.3	0.55	0.68	disease	0.83	disease	0.78	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.35	low_impact	-1.48	low_impact	3.25	high_impact	0.25	0.9	NA	NA	0.68	P	0.88	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7411	7411	A	T	MI.5105	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1508	503	H	L	cAc/cTc	5.6	1	0	probably_damaging	0.93	deleterious	0	neutral	2.72	deleterious	-6.21	deleterious	-2.88	high_impact	4.71	0.68	neutral	0.13	damaging	4.01	23.60	deleterious	0.32	0.55	0.29	neutral	0.87	disease	0.8	disease	0.79	disease	6	1	deleterious	0.04	neutral	6	deleterious	0.72	deleterious	-1.81	low_impact	-1.48	low_impact	3.25	high_impact	0.30	0.9	NA	NA	0.66	P	0.91	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7412	7412	C	G	MI.5106	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1509	503	H	Q	caC/caG	6.98	1	0	probably_damaging	0.96	deleterious	0	neutral	2.67	deleterious	-5.05	neutral	-2.1	high_impact	4.37	0.61	neutral	0.15	damaging	3.64	23.20	deleterious	0.57	0.6	0.48	neutral	0.76	disease	0.76	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.06	low_impact	-1.48	low_impact	2.94	high_impact	0.39	0.9	NA	NA	0.51	P	0.84	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7412	7412	C	A	MI.5107	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1509	503	H	Q	caC/caA	6.98	1	0	probably_damaging	0.96	deleterious	0	neutral	2.67	deleterious	-5.05	neutral	-2.1	high_impact	4.37	0.61	neutral	0.15	damaging	3.97	23.60	deleterious	0.57	0.6	0.48	neutral	0.76	disease	0.76	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.74	deleterious	-2.06	low_impact	-1.48	low_impact	2.94	high_impact	0.39	0.9	NA	NA	0.51	P	0.84	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7413	7413	A	G	MI.5108	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1510	504	T	A	Aca/Gca	-0.4	0.35	0	probably_damaging	0.94	deleterious	0	neutral	2.96	neutral	0.1	neutral	-0.54	medium_impact	2.8	0.5	damaging	0.1	damaging	3.53	23.10	deleterious	0.6	0.65	0.23	neutral	0.3	neutral	0.46	neutral	0.45	neutral	1	1	deleterious	0.03	neutral	5	deleterious	0.61	deleterious	-1.88	low_impact	-1.48	low_impact	1.49	medium_impact	0.50	0.9	NA	NA	0.41	N	0.65	disease_causing	0.83	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7413	7413	A	C	MI.5109	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1510	504	T	P	Aca/Cca	-0.4	0.35	0	probably_damaging	0.99	deleterious	0	neutral	2.94	neutral	-2.12	neutral	-0.94	high_impact	3.95	0.47	damaging	0.09	damaging	3.63	23.20	deleterious	0.19	0.55	0.51	disease	0.69	disease	0.53	disease	0.63	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-2.64	low_impact	-1.48	low_impact	2.55	high_impact	0.56	0.9	NA	NA	0.36	N	0.91	disease_causing	0.96	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8764	8764	G	T	MI.511	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	238	80	A	S	Gcc/Tcc	-7.51	0	0.02	benign	0.19	deleterious	0.04	neutral	4.36	neutral	-1.6	neutral	-0.89	neutral_impact	-0.04	0.88	neutral	0.91	neutral	0.64	8.45	deleterious	0.4	0.65	0.57	disease	0.3	neutral	0.4	neutral	0.57	disease	1	0.95	neutral	0.43	neutral	-2	neutral	0.24	neutral	-0.16	medium_impact	-0.49	medium_impact	-1.13	low_impact	0.72	0.9	25.66	23.52	0.46	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7413	7413	A	T	MI.5110	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1510	504	T	S	Aca/Tca	-0.4	0.35	0	probably_damaging	0.94	neutral	0.56	neutral	3.22	neutral	3.82	neutral	0.02	low_impact	1.07	0.55	damaging	0.18	damaging	0.94	10.33	neutral	0.53	0.6	0.22	neutral	0.04	neutral	0.16	neutral	0.25	neutral	5	0.93	neutral	0.31	neutral	-2	neutral	0.58	deleterious	-1.88	low_impact	0.25	medium_impact	-0.11	medium_impact	0.51	0.9	NA	NA	0.41	N	0.77	disease_causing	0.63	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7414	7414	C	T	MI.5111	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1511	504	T	M	aCa/aTa	8.59	1	0	probably_damaging	1	deleterious	0	neutral	2.89	neutral	-1.78	neutral	-0.93	medium_impact	3.15	0.54	damaging	0.1	damaging	4.19	23.80	deleterious	0.42	0.55	0.6	disease	0.42	neutral	0.59	disease	0.66	disease	3	1	deleterious	0	neutral	5	deleterious	0.68	deleterious	-3.58	low_impact	-1.48	low_impact	1.81	medium_impact	0.74	0.9	NA	NA	0.49	P	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7414	7414	C	A	MI.5112	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1511	504	T	K	aCa/aAa	8.59	1	0	probably_damaging	1	deleterious	0	neutral	2.97	neutral	-1.4	neutral	-0.78	high_impact	3.6	0.5	damaging	0.08	damaging	4.70	24.60	deleterious	0.4	0.55	0.24	neutral	0.6	disease	0.63	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.68	deleterious	-3.58	low_impact	-1.48	low_impact	2.23	high_impact	0.74	0.9	NA	NA	0.51	P	0.87	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7416	7416	T	A	MI.5113	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1513	505	F	I	Ttc/Atc	-0.17	0.58	0	probably_damaging	0.99	deleterious	0	neutral	2.79	deleterious	-5.91	neutral	-1.07	medium_impact	3.12	0.66	neutral	0.17	damaging	4.58	24.40	deleterious	0.28	0.55	0.35	neutral	0.54	disease	0.64	disease	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.69	deleterious	-2.64	low_impact	-1.48	low_impact	1.78	medium_impact	0.48	0.9	NA	NA	0.34	N	0.87	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7416	7416	T	G	MI.5114	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1513	505	F	V	Ttc/Gtc	-0.17	0.58	0	probably_damaging	1	deleterious	0.01	neutral	2.79	deleterious	-5.81	neutral	-1.15	high_impact	3.58	0.64	neutral	0.16	damaging	4.31	24.00	deleterious	0.34	0.55	0.37	neutral	0.74	disease	0.72	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.71	deleterious	-3.58	low_impact	-0.92	medium_impact	2.21	high_impact	0.32	0.9	NA	NA	0.31	N	0.84	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7416	7416	T	C	MI.5115	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1513	505	F	L	Ttc/Ctc	-0.17	0.58	0	probably_damaging	0.98	neutral	0.06	neutral	2.83	deleterious	-4.78	neutral	-1.06	medium_impact	2.88	0.69	neutral	0.2	damaging	3.15	22.60	deleterious	0.44	0.55	0.34	neutral	0.55	disease	0.61	disease	0.51	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.69	deleterious	-2.35	low_impact	-0.47	medium_impact	1.56	medium_impact	0.37	0.9	NA	NA	0.35	N	0.81	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7417	7417	T	C	MI.5116	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1514	505	F	S	tTc/tCc	7.44	1	0	probably_damaging	1	deleterious	0	neutral	2.76	deleterious	-6.45	neutral	-1.22	medium_impact	3.03	0.71	neutral	0.17	damaging	4.44	24.20	deleterious	0.37	0.55	0.5	disease	0.68	disease	0.65	disease	0.68	disease	4	1	deleterious	0	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-1.48	low_impact	1.7	medium_impact	0.28	0.9	NA	NA	0.45	N	0.85	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7417	7417	T	A	MI.5117	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1514	505	F	Y	tTc/tAc	7.44	1	0	probably_damaging	0.98	neutral	0.86	neutral	2.93	neutral	-2.62	neutral	0.42	neutral_impact	0.06	0.67	neutral	0.35	neutral	1.79	14.92	neutral	0.43	0.55	0.52	disease	0.08	neutral	0.34	neutral	0.28	neutral	4	0.98	deleterious	0.44	neutral	-2	neutral	0.67	deleterious	-2.35	low_impact	0.63	medium_impact	-1.04	low_impact	0.45	0.9	NA	NA	0.51	P	0.58	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7417	7417	T	G	MI.5118	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1514	505	F	C	tTc/tGc	7.44	1	0	probably_damaging	1	deleterious	0.01	neutral	2.72	deleterious	-7.96	neutral	-1.39	medium_impact	3.23	0.65	neutral	0.16	damaging	4.24	23.90	deleterious	0.25	0.55	0.74	disease	0.75	disease	0.65	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.78	deleterious	-3.58	low_impact	-0.92	medium_impact	1.88	medium_impact	0.21	0.9	NA	NA	0.44	N	0.91	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7418	7418	C	A	MI.5119	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1515	505	F	L	ttC/ttA	2.6	0.99	0	probably_damaging	0.98	neutral	0.06	neutral	2.83	deleterious	-4.78	neutral	-1.06	medium_impact	2.88	0.69	neutral	0.2	damaging	3.68	23.30	deleterious	0.44	0.55	0.34	neutral	0.55	disease	0.61	disease	0.51	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.69	deleterious	-2.35	low_impact	-0.47	medium_impact	1.56	medium_impact	0.37	0.9	NA	NA	0.51	N	0.81	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8765	8765	C	T	MI.512	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	239	80	A	V	gCc/gTc	-0.1	0	0	benign	0.19	neutral	0.24	neutral	4.42	neutral	0.55	neutral	-0.8	neutral_impact	-0.84	0.9	neutral	0.78	neutral	0.51	7.49	deleterious	0.42	0.65	0.38	neutral	0.35	neutral	0.25	neutral	0.47	neutral	1	0.72	neutral	0.53	deleterious	-6	neutral	0.25	neutral	-0.16	medium_impact	0.01	medium_impact	-1.82	low_impact	0.71	0.9	25.66	23.52	0.45	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7418	7418	C	G	MI.5120	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1515	505	F	L	ttC/ttG	2.6	0.99	0	probably_damaging	0.98	neutral	0.06	neutral	2.83	deleterious	-4.78	neutral	-1.06	medium_impact	2.88	0.69	neutral	0.2	damaging	3.40	23.00	deleterious	0.44	0.55	0.34	neutral	0.55	disease	0.61	disease	0.51	disease	0	1	deleterious	0.04	neutral	1	deleterious	0.69	deleterious	-2.35	low_impact	-0.47	medium_impact	1.56	medium_impact	0.37	0.9	NA	NA	0.48	N	0.81	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7419	7419	G	C	MI.5121	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1516	506	E	Q	Gaa/Caa	-3.17	0	0	benign	0.12	neutral	0.4	neutral	2.93	neutral	-0.69	neutral	-0.19	medium_impact	2.83	0.65	neutral	0.54	neutral	0.32	5.92	deleterious	0.4	0.55	0.32	neutral	0.17	neutral	0.31	neutral	0.32	neutral	4	0.53	neutral	0.64	deleterious	-3	neutral	0.25	neutral	0.06	medium_impact	0.1	medium_impact	1.51	medium_impact	0.63	0.9	7.8	32.1	0.49	N	0.66	polymorphism	0.65	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7419	7419	G	A	MI.5122	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1516	506	E	K	Gaa/Aaa	-3.17	0	0	benign	0.1	neutral	0.24	neutral	2.96	neutral	-0.12	neutral	-0.27	medium_impact	2.72	0.62	neutral	0.57	neutral	1.44	13.02	neutral	0.35	0.55	0.22	neutral	0.34	neutral	0.5	neutral	0.45	neutral	1	0.73	neutral	0.57	deleterious	-3	neutral	0.28	neutral	0.14	medium_impact	-0.09	medium_impact	1.41	medium_impact	0.75	0.9	7.8	32.1	0.51	N	0.72	disease_causing	0.7	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7420	7420	A	C	MI.5123	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1517	506	E	A	gAa/gCa	6.06	1	0	benign	0.18	neutral	0.17	neutral	3.04	neutral	0.07	neutral	-0.49	medium_impact	2.33	0.63	neutral	0.64	neutral	0.68	8.68	deleterious	0.36	0.55	0.14	neutral	0.2	neutral	0.46	neutral	0.36	neutral	3	0.8	neutral	0.5	deleterious	-3	neutral	0.21	neutral	-0.14	medium_impact	-0.19	medium_impact	1.05	medium_impact	0.63	0.9	7.8	32.1	0.67	P	0.70	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7420	7420	A	G	MI.5124	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1517	506	E	G	gAa/gGa	6.06	1	0	benign	0.14	neutral	0.08	neutral	2.96	neutral	-1.01	neutral	-0.49	medium_impact	2.62	0.63	neutral	0.58	neutral	1.30	12.28	neutral	0.35	0.55	0.34	neutral	0.25	neutral	0.51	disease	0.46	neutral	1	0.91	neutral	0.47	deleterious	-3	neutral	0.33	neutral	-0.01	medium_impact	-0.4	medium_impact	1.32	medium_impact	0.44	0.9	7.8	32.1	0.68	P	0.67	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7420	7420	A	T	MI.5125	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1517	506	E	V	gAa/gTa	6.06	1	0	benign	0.25	neutral	0.1	neutral	2.93	neutral	-1.21	neutral	-0.83	medium_impact	2.72	0.61	neutral	0.5	neutral	1.34	12.48	neutral	0.31	0.55	0.49	neutral	0.41	neutral	0.5	neutral	0.43	neutral	1	0.88	neutral	0.43	neutral	-3	neutral	0.42	neutral	-0.31	medium_impact	-0.34	medium_impact	1.41	medium_impact	0.60	0.9	7.8	32.1	0.63	P	0.68	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7421	7421	A	C	MI.5126	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1518	506	E	D	gaA/gaC	8.59	1	0	benign	0	neutral	0.19	neutral	3	neutral	-0.49	neutral	-0.1	low_impact	1.86	0.62	neutral	0.58	neutral	0.34	6.06	deleterious	0.51	0.6	0.29	neutral	0.17	neutral	0.25	neutral	0.31	neutral	4	0.81	neutral	0.6	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	-0.16	medium_impact	0.62	medium_impact	0.75	0.9	7.8	32.1	0.71	P	0.70	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7421	7421	A	T	MI.5127	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1518	506	E	D	gaA/gaT	8.59	1	0	benign	0	neutral	0.19	neutral	3	neutral	-0.49	neutral	-0.1	low_impact	1.86	0.62	neutral	0.58	neutral	0.46	7.09	deleterious	0.51	0.6	0.29	neutral	0.17	neutral	0.25	neutral	0.31	neutral	4	0.81	neutral	0.6	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	-0.16	medium_impact	0.62	medium_impact	0.75	0.9	7.8	32.1	0.7	P	0.70	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7422	7422	G	C	MI.5128	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1519	507	E	Q	Gaa/Caa	0.52	0.99	0	probably_damaging	0.99	neutral	0.05	neutral	2.71	deleterious	-3.94	neutral	-0.34	medium_impact	3.15	0.49	damaging	0.67	neutral	2.31	18.25	deleterious	0.59	0.65	0.28	neutral	0.34	neutral	0.41	neutral	0.39	neutral	2	1	deleterious	0.03	neutral	1	deleterious	0.70	deleterious	-2.64	low_impact	-0.52	medium_impact	1.81	medium_impact	0.94	0.95	8.38	26.27	0.61	P	0.11	disease_causing	0.99	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7422	7422	G	A	MI.5129	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1519	507	E	K	Gaa/Aaa	0.52	0.99	0	probably_damaging	1	deleterious	0.01	neutral	2.72	deleterious	-3.47	neutral	-0.61	high_impact	4.27	0.55	damaging	0.15	damaging	4.68	24.60	deleterious	0.55	0.6	0.21	neutral	0.64	disease	0.7	disease	0.62	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.74	deleterious	-3.58	low_impact	-0.92	medium_impact	2.84	high_impact	0.87	0.9	8.38	26.27	0.46	N	0.66	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8765	8765	C	G	MI.513	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	239	80	A	G	gCc/gGc	-0.1	0	0	benign	0.19	neutral	0.18	neutral	4.35	neutral	-2.55	neutral	-1.15	neutral_impact	0.05	0.85	neutral	0.97	neutral	0.63	8.39	deleterious	0.31	0.65	0.48	neutral	0.25	neutral	0.32	neutral	0.41	neutral	2	0.79	neutral	0.5	deleterious	-6	neutral	0.24	neutral	-0.16	medium_impact	-0.08	medium_impact	-1.06	low_impact	0.72	0.9	25.66	23.52	0.49	N	0.02	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7423	7423	A	T	MI.5130	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1520	507	E	V	gAa/gTa	4.21	1	0	probably_damaging	1	deleterious	0	neutral	2.73	deleterious	-4.05	neutral	-0.49	high_impact	4.07	0.56	damaging	0.17	damaging	4.20	23.90	deleterious	0.4	0.55	0.47	neutral	0.72	disease	0.7	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.58	low_impact	-1.48	low_impact	2.66	high_impact	0.84	0.9	8.38	26.27	0.49	N	0.78	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7423	7423	A	G	MI.5131	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1520	507	E	G	gAa/gGa	4.21	1	0	probably_damaging	1	deleterious	0.01	neutral	2.71	deleterious	-4.75	neutral	-1.14	high_impact	4.62	0.54	damaging	0.19	damaging	4.33	24.00	deleterious	0.47	0.55	0.53	disease	0.54	disease	0.69	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.58	low_impact	-0.92	medium_impact	3.17	high_impact	0.77	0.9	8.38	26.27	0.57	P	0.54	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7423	7423	A	C	MI.5132	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1520	507	E	A	gAa/gCa	4.21	1	0	probably_damaging	1	deleterious	0.02	neutral	2.72	deleterious	-3.76	neutral	-0.75	high_impact	4.27	0.66	neutral	0.18	damaging	3.77	23.40	deleterious	0.55	0.6	0.36	neutral	0.49	neutral	0.67	disease	0.64	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.72	deleterious	-3.58	low_impact	-0.75	medium_impact	2.84	high_impact	0.86	0.9	8.38	26.27	0.48	P	0.54	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7424	7424	A	C	MI.5133	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1521	507	E	D	gaA/gaC	6.75	1	0.01	probably_damaging	0.94	deleterious	0.01	neutral	2.72	deleterious	-3.76	neutral	-0.58	high_impact	3.58	0.63	neutral	0.16	damaging	3.79	23.40	deleterious	0.58	0.65	0.41	neutral	0.46	neutral	0.4	neutral	0.42	neutral	2	1	deleterious	0.04	neutral	6	deleterious	0.68	deleterious	-1.88	low_impact	-0.92	medium_impact	2.21	high_impact	0.97	1	8.38	26.27	0.6	P	0.51	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7424	7424	A	T	MI.5134	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1521	507	E	D	gaA/gaT	6.75	1	0.01	probably_damaging	0.94	deleterious	0.01	neutral	2.72	deleterious	-3.76	neutral	-0.58	high_impact	3.58	0.63	neutral	0.16	damaging	3.89	23.50	deleterious	0.58	0.65	0.41	neutral	0.46	neutral	0.4	neutral	0.42	neutral	2	1	deleterious	0.04	neutral	6	deleterious	0.68	deleterious	-1.88	low_impact	-0.92	medium_impact	2.21	high_impact	0.97	1	8.38	26.27	0.6	P	0.51	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7425	7425	C	G	MI.5135	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1522	508	P	A	Ccc/Gcc	-0.63	0.02	0	benign	0	neutral	0.65	neutral	3.05	neutral	-1.79	neutral	-0.22	medium_impact	2.51	0.64	neutral	0.61	neutral	0.19	4.60	deleterious	0.42	0.55	0.4	neutral	0.2	neutral	0.38	neutral	0.3	neutral	4	0.35	neutral	0.83	deleterious	-3	neutral	0.12	neutral	2.07	high_impact	0.34	medium_impact	1.22	medium_impact	0.70	0.9	NA	NA	0.4	N	0.76	disease_causing	0.8	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7425	7425	C	A	MI.5136	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1522	508	P	T	Ccc/Acc	-0.63	0.02	0	benign	0.06	neutral	0.56	neutral	3.08	neutral	0.6	neutral	-0.06	low_impact	1.34	0.61	neutral	0.42	neutral	1.13	11.36	neutral	0.41	0.55	0.27	neutral	0.36	neutral	0.23	neutral	0.42	neutral	2	0.38	neutral	0.75	deleterious	-6	neutral	0.16	neutral	0.37	medium_impact	0.25	medium_impact	0.14	medium_impact	0.65	0.9	NA	NA	0.36	N	0.82	disease_causing	0.86	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7425	7425	C	T	MI.5137	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1522	508	P	S	Ccc/Tcc	-0.63	0.02	0	benign	0	neutral	0.49	neutral	3.03	neutral	-2.06	neutral	-0.29	medium_impact	2.23	0.61	neutral	0.56	neutral	3.64	23.20	deleterious	0.46	0.55	0.49	neutral	0.32	neutral	0.23	neutral	0.4	neutral	2	0.51	neutral	0.75	deleterious	-3	neutral	0.16	neutral	2.07	high_impact	0.18	medium_impact	0.96	medium_impact	0.28	0.9	NA	NA	0.46	N	0.84	disease_causing	0.86	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7426	7426	C	A	MI.5138	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1523	508	P	H	cCc/cAc	5.6	1	0	possibly_damaging	0.7	neutral	0.39	neutral	2.99	deleterious	-4.59	neutral	-0.59	medium_impact	3.21	0.62	neutral	0.36	neutral	4.44	24.20	deleterious	0.42	0.55	0.71	disease	0.41	neutral	0.31	neutral	0.62	disease	2	0.72	neutral	0.35	neutral	0	NA	0.65	deleterious	-1.1	low_impact	0.09	medium_impact	1.87	medium_impact	0.58	0.9	NA	NA	0.59	P	0.82	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7426	7426	C	G	MI.5139	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1523	508	P	R	cCc/cGc	5.6	1	0	benign	0.39	neutral	0.28	neutral	3	deleterious	-3.47	neutral	-0.47	medium_impact	3.21	0.57	damaging	0.44	neutral	3.92	23.50	deleterious	0.44	0.55	0.61	disease	0.5	neutral	0.51	disease	0.54	disease	1	0.67	neutral	0.45	neutral	-3	neutral	0.58	deleterious	-0.57	medium_impact	-0.04	medium_impact	1.87	medium_impact	0.56	0.9	NA	NA	0.6	P	0.87	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8765	8765	C	A	MI.514	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	239	80	A	D	gCc/gAc	-0.1	0	0	possibly_damaging	0.48	deleterious	0.01	neutral	4.34	deleterious	-3.48	deleterious	-2.78	low_impact	1.15	0.85	neutral	0.45	neutral	2.78	21.30	deleterious	0.18	0.65	0.83	disease	0.67	disease	0.58	disease	0.72	disease	4	0.99	deleterious	0.27	neutral	1	deleterious	0.57	deleterious	-0.72	medium_impact	-0.84	medium_impact	-0.11	medium_impact	0.64	0.9	25.66	23.52	0.3	N	0.73	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7426	7426	C	T	MI.5140	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1523	508	P	L	cCc/cTc	5.6	1	0	benign	0.2	neutral	1	neutral	3.23	deleterious	-3.29	neutral	0.29	neutral_impact	0.62	0.57	damaging	0.5	neutral	1.54	13.53	neutral	0.44	0.55	0.14	neutral	0.26	neutral	0.27	neutral	0.38	neutral	2	0.2	neutral	0.9	deleterious	-6	neutral	0.29	neutral	-0.19	medium_impact	1.86	high_impact	-0.53	medium_impact	0.70	0.9	NA	NA	0.5	N	0.89	disease_causing	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7428	7428	G	C	MI.5141	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1525	509	V	L	Gta/Cta	-16.08	0	0	benign	0.01	neutral	0.25	neutral	2.97	neutral	-2.72	neutral	-0.08	low_impact	0.8	0.69	neutral	0.69	neutral	0.65	8.50	deleterious	0.65	0.7	0.2	neutral	0.08	neutral	0.25	neutral	0.16	neutral	7	0.75	neutral	0.62	deleterious	-6	neutral	0.05	neutral	1.12	medium_impact	-0.07	medium_impact	-0.36	medium_impact	0.68	0.9	11.7	13.89	0.55	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7428	7428	G	A	MI.5142	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1525	509	V	M	Gta/Ata	-16.08	0	0	benign	0.2	neutral	0.15	neutral	2.89	deleterious	-4.4	neutral	-0.03	low_impact	1.01	0.66	neutral	0.74	neutral	1.11	11.26	neutral	0.48	0.55	0.36	neutral	0.07	neutral	0.14	neutral	0.16	neutral	7	0.82	neutral	0.48	deleterious	-6	neutral	0.19	neutral	-0.19	medium_impact	-0.23	medium_impact	-0.17	medium_impact	0.79	0.9	11.7	13.89	0.6	P	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7428	7428	G	T	MI.5143	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1525	509	V	L	Gta/Tta	-16.08	0	0	benign	0.01	neutral	0.25	neutral	2.97	neutral	-2.72	neutral	-0.08	low_impact	0.8	0.69	neutral	0.69	neutral	0.74	9.09	deleterious	0.65	0.7	0.2	neutral	0.08	neutral	0.25	neutral	0.16	neutral	7	0.75	neutral	0.62	deleterious	-6	neutral	0.05	neutral	1.12	medium_impact	-0.07	medium_impact	-0.36	medium_impact	0.68	0.9	11.7	13.89	0.55	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7429	7429	T	A	MI.5144	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1526	509	V	E	gTa/gAa	-0.63	0	0	benign	0.02	deleterious	0.04	neutral	2.92	deleterious	-4.59	neutral	-0.22	low_impact	1.7	0.61	neutral	0.62	neutral	2.01	16.26	deleterious	0.34	0.55	0.31	neutral	0.3	neutral	0.4	neutral	0.42	neutral	2	0.96	neutral	0.51	deleterious	-2	neutral	0.12	neutral	0.83	medium_impact	-0.58	medium_impact	0.47	medium_impact	0.38	0.9	11.7	13.89	0.53	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7429	7429	T	C	MI.5145	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1526	509	V	A	gTa/gCa	-0.63	0	0	benign	0	neutral	0.85	neutral	2.97	neutral	-2.93	neutral	-0.03	neutral_impact	-0.78	0.75	neutral	0.97	neutral	-0.57	0.15	neutral	0.48	0.55	0.19	neutral	0.04	neutral	0.16	neutral	0.14	neutral	7	0.15	neutral	0.93	deleterious	-6	neutral	0.05	neutral	2.07	high_impact	0.61	medium_impact	-1.82	low_impact	0.44	0.9	11.7	13.89	0.45	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7429	7429	T	G	MI.5146	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1526	509	V	G	gTa/gGa	-0.63	0	0	benign	0.02	neutral	0.08	neutral	2.88	deleterious	-4.38	neutral	-0.24	low_impact	0.9	0.66	neutral	0.66	neutral	2.26	17.89	deleterious	0.29	0.55	0.38	neutral	0.19	neutral	0.45	neutral	0.33	neutral	3	0.92	neutral	0.53	deleterious	-6	neutral	0.09	neutral	0.83	medium_impact	-0.4	medium_impact	-0.27	medium_impact	0.54	0.9	11.7	13.89	0.5	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7431	7431	T	C	MI.5147	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1528	510	Y	H	Tac/Cac	-13.31	0	0	possibly_damaging	0.85	neutral	0.08	neutral	2.96	neutral	-1.28	neutral	-0.26	low_impact	0.8	0.73	neutral	0.85	neutral	2.53	19.63	deleterious	0.84	0.85	0.42	neutral	0.1	neutral	0.2	neutral	0.2	neutral	6	0.96	neutral	0.12	neutral	-3	neutral	0.59	deleterious	-1.47	low_impact	-0.4	medium_impact	-0.36	medium_impact	0.43	0.9	9.16	31.3	0.52	N	0.80	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7431	7431	T	G	MI.5148	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1528	510	Y	D	Tac/Gac	-13.31	0	0	possibly_damaging	0.9	deleterious	0.01	neutral	2.97	neutral	-1.05	neutral	-0.37	medium_impact	2.25	0.59	damaging	0.53	neutral	4.15	23.80	deleterious	0.55	0.6	0.41	neutral	0.29	neutral	0.48	neutral	0.43	neutral	1	1	deleterious	0.06	neutral	4	deleterious	0.65	deleterious	-1.65	low_impact	-0.92	medium_impact	0.98	medium_impact	0.46	0.9	9.16	31.3	0.46	N	0.87	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7431	7431	T	A	MI.5149	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1528	510	Y	N	Tac/Aac	-13.31	0	0	possibly_damaging	0.9	neutral	0.14	neutral	2.97	neutral	-0.86	neutral	-0.14	medium_impact	2.25	0.65	neutral	0.64	neutral	4.26	23.90	deleterious	0.5	0.6	0.35	neutral	0.2	neutral	0.42	neutral	0.32	neutral	4	0.95	neutral	0.12	neutral	0	NA	0.63	deleterious	-1.65	low_impact	-0.25	medium_impact	0.98	medium_impact	0.34	0.9	9.16	31.3	0.52	N	0.81	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8767	8767	A	C	MI.515	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	241	81	T	P	Aca/Cca	-9.36	0	0	possibly_damaging	0.68	neutral	0.11	neutral	4.28	neutral	-2.96	deleterious	-3.22	medium_impact	3.2	0.76	neutral	0.42	neutral	3.16	22.60	deleterious	0.12	0.65	0.81	disease	0.85	disease	0.67	disease	0.77	disease	5	0.9	neutral	0.22	neutral	0	NA	0.77	deleterious	-1.07	low_impact	-0.22	medium_impact	1.65	medium_impact	0.62	0.9	26.99	25.17	0.32	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7432	7432	A	T	MI.5150	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1529	510	Y	F	tAc/tTc	4.67	0.83	0	benign	0.01	neutral	1	neutral	3	neutral	-0.25	neutral	0.09	neutral_impact	-0.4	0.77	neutral	0.96	neutral	-1.00	0.02	neutral	0.53	0.6	0.18	neutral	0.03	neutral	0.18	neutral	0.2	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.07	neutral	1.12	medium_impact	1.86	high_impact	-1.47	low_impact	0.36	0.9	9.16	31.3	0.37	N	0.22	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7432	7432	A	C	MI.5151	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1529	510	Y	S	tAc/tCc	4.67	0.83	0	possibly_damaging	0.66	deleterious	0.04	neutral	3.02	neutral	-0.17	neutral	0	neutral_impact	0.68	0.65	neutral	0.67	neutral	2.69	20.80	deleterious	0.67	0.7	0.23	neutral	0.17	neutral	0.43	neutral	0.25	neutral	5	0.96	neutral	0.19	neutral	1	deleterious	0.56	deleterious	-1.03	low_impact	-0.58	medium_impact	-0.47	medium_impact	0.41	0.9	9.16	31.3	0.54	P	0.75	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7432	7432	A	G	MI.5152	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1529	510	Y	C	tAc/tGc	4.67	0.83	0	probably_damaging	0.93	deleterious	0.01	neutral	2.94	neutral	-2.45	neutral	-0.11	low_impact	1.9	0.59	damaging	0.54	neutral	3.70	23.30	deleterious	0.68	0.7	0.46	neutral	0.25	neutral	0.28	neutral	0.43	neutral	1	1	deleterious	0.04	neutral	2	deleterious	0.62	deleterious	-1.81	low_impact	-0.92	medium_impact	0.66	medium_impact	0.15	0.9	9.16	31.3	0.53	P	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7434	7434	A	G	MI.5153	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1531	511	M	V	Ata/Gta	-6.63	0	0	benign	0	neutral	1	neutral	3.14	neutral	1.85	neutral	0.15	neutral_impact	-1.68	0.81	neutral	0.98	neutral	-1.66	0.00	neutral	0.73	0.75	0.32	neutral	0.03	neutral	0.23	neutral	0.08	neutral	8	0	neutral	1	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	1.86	high_impact	-2.65	low_impact	0.32	0.9	NA	NA	0.29	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7434	7434	A	T	MI.5154	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1531	511	M	L	Ata/Tta	-6.63	0	0	benign	0	neutral	0.47	neutral	3.19	neutral	1.99	neutral	0.15	neutral_impact	-1.23	0.67	neutral	0.81	neutral	0.32	5.86	deleterious	0.67	0.7	0.14	neutral	0.08	neutral	0.2	neutral	0.1	neutral	8	0.53	neutral	0.74	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.16	medium_impact	-2.24	low_impact	0.34	0.9	NA	NA	0.49	N	0.16	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7434	7434	A	C	MI.5155	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1531	511	M	L	Ata/Cta	-6.63	0	0	benign	0	neutral	0.47	neutral	3.19	neutral	1.99	neutral	0.15	neutral_impact	-1.23	0.67	neutral	0.81	neutral	0.28	5.54	deleterious	0.67	0.7	0.14	neutral	0.08	neutral	0.2	neutral	0.1	neutral	8	0.53	neutral	0.74	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.16	medium_impact	-2.24	low_impact	0.34	0.9	NA	NA	0.49	N	0.16	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7435	7435	T	A	MI.5156	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1532	511	M	K	aTa/aAa	0.06	0.02	0	benign	0.03	deleterious	0	neutral	2.98	neutral	0.08	neutral	-0.41	low_impact	1.1	0.65	neutral	0.68	neutral	2.39	18.76	deleterious	0.37	0.55	0.37	neutral	0.25	neutral	0.48	neutral	0.4	neutral	2	1	deleterious	0.49	deleterious	-2	neutral	0.15	neutral	0.66	medium_impact	-1.48	low_impact	-0.08	medium_impact	0.43	0.9	NA	NA	0.5	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7435	7435	T	C	MI.5157	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1532	511	M	T	aTa/aCa	0.06	0.02	0	benign	0.01	deleterious	0	neutral	2.99	neutral	0.23	neutral	0.05	neutral_impact	0.2	0.64	neutral	0.78	neutral	1.36	12.56	neutral	0.62	0.65	0.24	neutral	0.14	neutral	0.28	neutral	0.15	neutral	7	1	deleterious	0.5	deleterious	-2	neutral	0.09	neutral	1.12	medium_impact	-1.48	low_impact	-0.91	medium_impact	0.10	0.9	NA	NA	0.55	P	0.17	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7436	7436	A	C	MI.5158	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1533	511	M	I	atA/atC	4.67	0.69	0	benign	0	neutral	0.47	neutral	3.12	neutral	1.74	neutral	0.19	neutral_impact	-1.1	0.81	neutral	0.99	neutral	0.16	4.23	deleterious	0.71	0.75	0.28	neutral	0.04	neutral	0.23	neutral	0.11	neutral	8	0.53	neutral	0.74	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.16	medium_impact	-2.12	low_impact	0.33	0.9	NA	NA	0.46	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7436	7436	A	T	MI.5159	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1533	511	M	I	atA/atT	4.67	0.69	0	benign	0	neutral	0.47	neutral	3.12	neutral	1.74	neutral	0.19	neutral_impact	-1.1	0.81	neutral	0.99	neutral	0.23	5.03	deleterious	0.71	0.75	0.28	neutral	0.04	neutral	0.23	neutral	0.11	neutral	8	0.53	neutral	0.74	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.16	medium_impact	-2.12	low_impact	0.33	0.9	NA	NA	0.47	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8767	8767	A	T	MI.516	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	241	81	T	S	Aca/Tca	-9.36	0	0	benign	0.03	neutral	0.64	neutral	4.38	neutral	-0.83	neutral	-0.33	neutral_impact	-0.14	0.86	neutral	0.94	neutral	-1.36	0.00	neutral	0.48	0.65	0.43	neutral	0.15	neutral	0.31	neutral	0.25	neutral	5	0.31	neutral	0.81	deleterious	-6	neutral	0.16	neutral	0.68	medium_impact	0.43	medium_impact	-1.22	low_impact	0.62	0.9	26.99	25.17	0.35	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7437	7437	A	G	MI.5160	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1534	512	K	E	Aaa/Gaa	-13.77	0	0	probably_damaging	0.98	deleterious	0.04	neutral	2.96	neutral	-0.56	neutral	-0.09	low_impact	1.04	0.67	neutral	0.33	neutral	3.18	22.70	deleterious	0.39	0.55	0.12	neutral	0.25	neutral	0.39	neutral	0.33	neutral	3	1	deleterious	0.03	neutral	2	deleterious	0.63	deleterious	-2.35	low_impact	-0.58	medium_impact	-0.14	medium_impact	0.67	0.9	7.6	59.6	0.43	N	0.40	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7437	7437	A	C	MI.5161	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1534	512	K	Q	Aaa/Caa	-13.77	0	0	probably_damaging	0.99	neutral	1	neutral	2.92	neutral	-1.05	neutral	-0.02	neutral_impact	-1.1	0.64	neutral	0.61	neutral	1.00	10.69	neutral	0.4	0.55	0.24	neutral	0.06	neutral	0.24	neutral	0.14	neutral	7	0.99	deleterious	0.51	deleterious	-2	neutral	0.61	deleterious	-2.64	low_impact	1.86	high_impact	-2.12	low_impact	0.72	0.9	7.6	59.6	0.33	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7438	7438	A	C	MI.5162	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1535	512	K	T	aAa/aCa	2.6	0.87	0	probably_damaging	0.99	neutral	0.32	neutral	2.93	neutral	-1.02	neutral	0.31	neutral_impact	-0.66	0.7	neutral	0.77	neutral	2.67	20.60	deleterious	0.35	0.55	0.31	neutral	0.2	neutral	0.38	neutral	0.27	neutral	5	0.99	deleterious	0.17	neutral	-2	neutral	0.65	deleterious	-2.64	low_impact	0.01	medium_impact	-1.71	low_impact	0.59	0.9	7.6	59.6	0.44	N	0.48	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7438	7438	A	T	MI.5163	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1535	512	K	M	aAa/aTa	2.6	0.87	0	probably_damaging	1	deleterious	0.01	neutral	2.87	neutral	-2.45	neutral	0.1	neutral_impact	0.14	0.68	neutral	0.37	neutral	4.02	23.60	deleterious	0.26	0.55	0.59	disease	0.15	neutral	0.28	neutral	0.21	neutral	6	1	deleterious	0.01	neutral	2	deleterious	0.66	deleterious	-3.58	low_impact	-0.92	medium_impact	-0.97	medium_impact	0.51	0.9	7.6	59.6	0.44	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7439	7439	A	C	MI.5164	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1536	512	K	N	aaA/aaC	3.75	0.88	0	probably_damaging	0.99	neutral	0.09	neutral	2.92	neutral	-1.17	neutral	0.22	neutral_impact	-0.11	0.72	neutral	0.94	neutral	2.98	22.20	deleterious	0.58	0.65	0.26	neutral	0.13	neutral	0.39	neutral	0.17	neutral	7	1	deleterious	0.05	neutral	-2	neutral	0.63	deleterious	-2.64	low_impact	-0.37	medium_impact	-1.2	low_impact	0.74	0.9	7.6	59.6	0.5	P	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7439	7439	A	T	MI.5165	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1536	512	K	N	aaA/aaT	3.75	0.88	0	probably_damaging	0.99	neutral	0.09	neutral	2.92	neutral	-1.17	neutral	0.22	neutral_impact	-0.11	0.72	neutral	0.94	neutral	3.06	22.40	deleterious	0.58	0.65	0.26	neutral	0.13	neutral	0.39	neutral	0.17	neutral	7	1	deleterious	0.05	neutral	-2	neutral	0.63	deleterious	-2.64	low_impact	-0.37	medium_impact	-1.2	low_impact	0.74	0.9	7.6	59.6	0.52	P	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7440	7440	T	G	MI.5166	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1537	513	S	A	Tct/Gct	0.75	0.09	0	benign	0	neutral	0.22	neutral	3.01	neutral	0.19	neutral	-0.08	neutral_impact	0	0.81	neutral	0.97	neutral	0.89	9.98	deleterious	0.46	0.55	0.17	neutral	0.02	neutral	0.51	disease	0.11	neutral	8	0.78	neutral	0.61	deleterious	-6	neutral	0.03	neutral	2.07	high_impact	-0.11	medium_impact	-1.1	low_impact	0.70	0.9	NA	NA	0.52	N	0.03	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7440	7440	T	C	MI.5167	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1537	513	S	P	Tct/Cct	0.75	0.09	0	benign	0.02	deleterious	0.02	neutral	2.92	neutral	-1.32	neutral	-0.18	neutral_impact	0	0.53	damaging	0.23	damaging	2.30	18.19	deleterious	0.4	0.55	0.37	neutral	0.22	neutral	0.56	disease	0.27	neutral	5	0.98	neutral	0.5	deleterious	-2	neutral	0.04	neutral	0.83	medium_impact	-0.75	medium_impact	-1.1	low_impact	0.57	0.9	NA	NA	0.45	N	0.08	polymorphism	1	0.03	.	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7440	7440	T	A	MI.5168	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1537	513	S	T	Tct/Act	0.75	0.09	0	benign	0	neutral	0.7	neutral	2.96	neutral	-0.47	neutral	-0.03	neutral_impact	0	0.81	neutral	0.98	neutral	-0.41	0.37	neutral	0.47	0.55	0.22	neutral	0.02	neutral	0.45	neutral	0.1	neutral	8	0.3	neutral	0.85	deleterious	-6	neutral	0.03	neutral	2.07	high_impact	0.4	medium_impact	-1.1	low_impact	0.74	0.9	NA	NA	0.46	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7441	7441	C	T	MI.5169	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1538	513	S	F	tCt/tTt	-2.48	0.01	0.01	benign	0.06	deleterious	0.01	neutral	2.93	neutral	-1.06	neutral	0.15	neutral_impact	0	0.64	neutral	0.25	damaging	2.45	19.15	deleterious	0.35	0.55	0.51	disease	0.12	neutral	0.62	disease	0.18	neutral	6	0.99	deleterious	0.48	deleterious	-2	neutral	0.12	neutral	0.37	medium_impact	-0.92	medium_impact	-1.1	low_impact	0.48	0.9	NA	NA	0.4	N	0.31	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8767	8767	A	G	MI.517	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	241	81	T	A	Aca/Gca	-9.36	0	0	benign	0.28	neutral	0.26	neutral	4.35	neutral	0.46	neutral	-1.67	low_impact	1.88	0.91	neutral	0.82	neutral	0.45	7.07	deleterious	0.68	0.75	0.35	neutral	0.42	neutral	0.48	neutral	0.47	neutral	1	0.69	neutral	0.49	deleterious	-6	neutral	0.33	neutral	-0.37	medium_impact	0.04	medium_impact	0.51	medium_impact	0.47	0.9	26.99	25.17	0.41	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7441	7441	C	A	MI.5170	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1538	513	S	Y	tCt/tAt	-2.48	0.01	0.01	benign	0.09	deleterious	0.01	neutral	2.92	neutral	-1.3	neutral	-0.03	neutral_impact	0	0.63	neutral	0.29	neutral	2.44	19.05	deleterious	0.37	0.55	0.48	neutral	0.13	neutral	0.53	disease	0.18	neutral	7	0.99	deleterious	0.46	neutral	-2	neutral	0.11	neutral	0.19	medium_impact	-0.92	medium_impact	-1.1	low_impact	0.66	0.9	NA	NA	0.41	N	0.24	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7441	7441	C	G	MI.5171	MT-CO1	IV	ENSG00000198804	ENSP00000354499	ENST00000361624	COX1_HUMAN	P00395	4512	YP_003024028.1	1538	513	S	C	tCt/tGt	-2.48	0.01	0.01	benign	0.12	neutral	0.08	neutral	2.9	neutral	-2.2	neutral	-0.21	neutral_impact	0	0.59	damaging	0.31	neutral	1.82	15.12	deleterious	0.42	0.55	0.6	disease	0.11	neutral	0.59	disease	0.17	neutral	7	0.91	neutral	0.48	deleterious	-6	neutral	0.14	neutral	0.06	medium_impact	-0.4	medium_impact	-1.1	low_impact	0.71	0.9	NA	NA	0.41	N	0.30	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7586	7586	A	C	MI.5172	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	1	1	M	L	Atg/Ctg	-3.4	0	0	possibly_damaging	0.9	deleterious	0	neutral	1.28	neutral	-2.12	deleterious	-2.87	NA	NA	0.16	damaging	0.02	damaging	3.13	22.60	deleterious	0.35	0.5	NA	NA	0.22	neutral	0.56	disease	0.37	neutral	3	1	deleterious	0.05	neutral	3	deleterious	0.67	deleterious	NA	NA	NA	NA	NA	NA	0.33	0.8	68.72	19.52	0.76	P	0.70	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7586	7586	A	G	MI.5173	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	1	1	M	V	Atg/Gtg	-3.4	0	0	probably_damaging	0.94	deleterious	0	neutral	1.25	neutral	-2.64	deleterious	-3.82	NA	NA	0.12	damaging	0.01	damaging	2.51	19.52	deleterious	0.49	0.55	NA	NA	0.29	neutral	0.65	disease	0.39	neutral	2	1	deleterious	0.03	neutral	4	deleterious	0.70	deleterious	NA	NA	NA	NA	NA	NA	0.46	0.8	68.72	19.52	0.74	P	0.89	NA	NA	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7586	7586	A	T	MI.5174	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	1	1	M	L	Atg/Ttg	-3.4	0	0	possibly_damaging	0.9	deleterious	0	neutral	1.28	neutral	-2.12	deleterious	-2.87	NA	NA	0.16	damaging	0.02	damaging	3.10	22.50	deleterious	0.35	0.5	NA	NA	0.22	neutral	0.56	disease	0.37	neutral	3	1	deleterious	0.05	neutral	3	deleterious	0.67	deleterious	NA	NA	NA	NA	NA	NA	0.33	0.8	68.72	19.52	0.76	P	0.70	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7587	7587	T	A	MI.5175	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	2	1	M	K	aTg/aAg	6.98	1	0	probably_damaging	0.97	deleterious	0	neutral	1.27	neutral	-2.18	deleterious	-5.73	NA	NA	0.15	damaging	0.01	damaging	3.80	23.40	deleterious	0.3	0.45	NA	NA	0.44	neutral	0.67	disease	0.43	neutral	1	1	deleterious	0.02	neutral	4	deleterious	0.79	deleterious	NA	NA	NA	NA	NA	NA	0.36	0.8	68.72	19.52	0.83	P	1.00	NA	NA	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7587	7587	T	C	MI.5176	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	2	1	M	T	aTg/aCg	6.98	1	0	probably_damaging	0.97	deleterious	0	neutral	1.24	neutral	-2.89	deleterious	-5.73	NA	NA	0.16	damaging	0.02	damaging	2.73	21.00	deleterious	0.37	0.5	NA	NA	0.39	neutral	0.65	disease	0.39	neutral	2	1	deleterious	0.02	neutral	4	deleterious	0.79	deleterious	NA	NA	NA	NA	NA	NA	0.22	0.8	68.72	19.52	0.79	P	0.92	NA	NA	0.23	rs199474825	Pathogenic	Hepatic_failure,_early-onset,_and_neurologic_disorder_due_to_cytochrome_C_oxidase_deficiency	24697	MedGen:C0268237,OMIM:220110,Orphanet:ORPHA254905,SNOMED_CT:67434000	.	.	.	.	T7587C	Mitochondrial Encephalomyopathy	-	+	Reported	2	P	P	P	damaging
chrM	7588	7588	G	C	MI.5177	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	3	1	M	I	atG/atC	7.44	1	0	probably_damaging	0.96	deleterious	0	neutral	1.23	neutral	-2.92	deleterious	-3.82	NA	NA	0.16	damaging	0.01	damaging	3.33	22.90	deleterious	0.46	0.55	NA	NA	0.32	neutral	0.56	disease	0.37	neutral	3	1	deleterious	0.02	neutral	4	deleterious	0.75	deleterious	NA	NA	NA	NA	NA	NA	0.59	0.8	68.72	19.52	0.84	P	0.78	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7588	7588	G	T	MI.5178	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	3	1	M	I	atG/atT	7.44	1	0	probably_damaging	0.96	deleterious	0	neutral	1.23	neutral	-2.92	deleterious	-3.82	NA	NA	0.16	damaging	0.01	damaging	3.43	23.00	deleterious	0.46	0.55	NA	NA	0.32	neutral	0.56	disease	0.37	neutral	3	1	deleterious	0.02	neutral	4	deleterious	0.75	deleterious	NA	NA	NA	NA	NA	NA	0.59	0.8	68.72	19.52	0.84	P	0.78	NA	NA	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7589	7589	G	A	MI.5179	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	4	2	A	T	Gca/Aca	7.44	1	0	possibly_damaging	0.66	neutral	0.52	neutral	1.44	neutral	-1.4	deleterious	-3.6	low_impact	1.52	0.47	damaging	0.39	neutral	1.98	16.08	deleterious	0.67	0.7	NA	NA	0.16	neutral	0.15	neutral	0.23	neutral	5	0.63	neutral	0.43	neutral	-3	neutral	0.54	deleterious	-0.99	medium_impact	0.22	medium_impact	0.32	medium_impact	0.70	0.85	67.4	14.6	0.66	P	0.86	disease_causing	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8768	8768	C	T	MI.518	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	242	81	T	M	aCa/aTa	-0.33	0	0	probably_damaging	0.93	neutral	0.31	neutral	4.34	neutral	-1.05	deleterious	-2.61	low_impact	1.32	0.8	neutral	0.64	neutral	2.68	20.70	deleterious	0.41	0.65	0.5	disease	0.43	neutral	0.39	neutral	0.2	neutral	6	0.94	neutral	0.19	neutral	-2	neutral	0.68	deleterious	-1.82	low_impact	0.1	medium_impact	0.03	medium_impact	0.76	0.9	26.99	25.17	0.31	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7589	7589	G	T	MI.5180	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	4	2	A	S	Gca/Tca	7.44	1	0	possibly_damaging	0.45	neutral	0.75	neutral	1.58	neutral	-0.01	deleterious	-2.56	low_impact	1.1	0.49	damaging	0.45	neutral	0.62	8.29	deleterious	0.55	0.6	NA	NA	0.11	neutral	0.11	neutral	0.27	neutral	5	0.34	neutral	0.65	deleterious	-3	neutral	0.35	neutral	-0.64	medium_impact	0.47	medium_impact	-0.07	medium_impact	0.77	0.85	67.4	14.6	0.57	P	0.48	disease_causing	0.94	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7589	7589	G	C	MI.5181	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	4	2	A	P	Gca/Cca	7.44	1	0	benign	0.04	neutral	0.33	neutral	1.53	neutral	-0.42	deleterious	-4.49	low_impact	1.43	0.58	damaging	0.66	neutral	0.55	7.84	deleterious	0.38	0.5	NA	NA	0.38	neutral	0.13	neutral	0.2	neutral	6	0.65	neutral	0.65	deleterious	-6	neutral	0.19	neutral	0.57	medium_impact	0.04	medium_impact	0.24	medium_impact	0.72	0.85	67.4	14.6	0.58	P	0.51	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7590	7590	C	G	MI.5182	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	5	2	A	G	gCa/gGa	2.37	1	0	benign	0.37	neutral	0.33	neutral	1.39	neutral	-2.51	deleterious	-3.64	medium_impact	3.04	0.44	damaging	0.52	neutral	1.90	15.58	deleterious	0.55	0.6	NA	NA	0.26	neutral	0.39	neutral	0.2	neutral	6	0.61	neutral	0.48	deleterious	-3	neutral	0.29	neutral	-0.51	medium_impact	0.04	medium_impact	1.75	medium_impact	0.79	0.85	67.4	14.6	0.67	P	0.71	disease_causing	0.94	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7590	7590	C	A	MI.5183	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	5	2	A	E	gCa/gAa	2.37	1	0	possibly_damaging	0.83	neutral	0.7	neutral	1.45	neutral	-1.32	deleterious	-4.55	medium_impact	2.29	0.37	damaging	0.31	neutral	3.84	23.40	deleterious	0.45	0.55	NA	NA	0.43	neutral	0.47	neutral	0.24	neutral	5	0.8	neutral	0.44	neutral	0	NA	0.65	deleterious	-1.36	low_impact	0.41	medium_impact	1.04	medium_impact	0.62	0.8	67.4	14.6	0.75	P	0.90	disease_causing	0.97	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7590	7590	C	T	MI.5184	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	5	2	A	V	gCa/gTa	2.37	1	0	possibly_damaging	0.61	neutral	0.34	neutral	1.39	neutral	-2.51	deleterious	-3.75	medium_impact	2.92	0.41	damaging	0.39	neutral	2.48	19.36	deleterious	0.62	0.65	NA	NA	0.31	neutral	0.42	neutral	0.19	neutral	6	0.69	neutral	0.37	neutral	0	NA	0.57	deleterious	-0.9	medium_impact	0.05	medium_impact	1.63	medium_impact	0.69	0.85	67.4	14.6	0.73	P	0.76	disease_causing	0.96	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7592	7592	C	G	MI.5185	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	7	3	H	D	Cat/Gat	-6.63	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.58	neutral	-0.24	deleterious	-5.96	low_impact	1.62	0.55	damaging	0.21	damaging	3.68	23.30	deleterious	0.52	0.6	NA	NA	0.4	neutral	0.39	neutral	0.16	neutral	7	1	deleterious	0.11	neutral	-2	neutral	0.74	deleterious	-2.58	low_impact	-0.13	medium_impact	0.41	medium_impact	0.44	0.8	31.72	63.41	0.33	N	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7592	7592	C	A	MI.5186	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	7	3	H	N	Cat/Aat	-6.63	0	0	probably_damaging	0.99	neutral	0.34	neutral	1.6	neutral	0.3	deleterious	-4.36	low_impact	1.21	0.74	neutral	0.62	neutral	2.36	18.55	deleterious	0.72	0.75	NA	NA	0.26	neutral	0.25	neutral	0.18	neutral	6	0.99	deleterious	0.18	neutral	-2	neutral	0.70	deleterious	-2.58	low_impact	0.05	medium_impact	0.03	medium_impact	0.46	0.8	31.72	63.41	0.37	N	0.73	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7592	7592	C	T	MI.5187	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	7	3	H	Y	Cat/Tat	-6.63	0	0	probably_damaging	0.99	neutral	1	neutral	1.58	neutral	-0.22	neutral	-1.82	neutral_impact	0.76	0.78	neutral	0.97	neutral	1.65	14.13	neutral	0.6	0.65	NA	NA	0.19	neutral	0.16	neutral	0.19	neutral	6	0.99	deleterious	0.51	deleterious	-2	neutral	0.72	deleterious	-2.58	low_impact	1.86	high_impact	-0.39	medium_impact	0.35	0.8	31.72	63.41	0.32	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7593	7593	A	C	MI.5188	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	8	3	H	P	cAt/cCt	2.14	0.97	0	probably_damaging	1	neutral	0.2	neutral	1.56	neutral	-0.99	deleterious	-6.68	low_impact	0.99	0.48	damaging	0.17	damaging	2.98	22.20	deleterious	0.47	0.55	NA	NA	0.61	disease	0.34	neutral	0.5	disease	0	1	deleterious	0.1	neutral	-2	neutral	0.78	deleterious	-3.52	low_impact	-0.13	medium_impact	-0.18	medium_impact	0.24	0.8	31.72	63.41	0.45	N	0.93	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7593	7593	A	T	MI.5189	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	8	3	H	L	cAt/cTt	2.14	0.97	0	probably_damaging	0.99	neutral	0.65	neutral	1.69	neutral	1.73	deleterious	-6.72	low_impact	0.9	0.59	damaging	0.27	damaging	2.37	18.66	deleterious	0.34	0.5	NA	NA	0.31	neutral	0.31	neutral	0.17	neutral	7	0.99	deleterious	0.33	neutral	-2	neutral	0.71	deleterious	-2.58	low_impact	0.35	medium_impact	-0.26	medium_impact	0.36	0.8	31.72	63.41	0.35	N	0.79	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8768	8768	C	A	MI.519	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	242	81	T	K	aCa/aAa	-0.33	0	0	benign	0.39	neutral	0.15	neutral	4.29	neutral	-2.36	deleterious	-2.7	medium_impact	3.2	0.79	neutral	0.51	neutral	2.69	20.70	deleterious	0.19	0.65	0.75	disease	0.8	disease	0.65	disease	0.74	disease	5	0.82	neutral	0.38	neutral	-3	neutral	0.56	deleterious	-0.57	medium_impact	-0.13	medium_impact	1.65	medium_impact	0.74	0.9	26.99	25.17	0.3	N	0.52	polymorphism	1	0.28	rs386829048	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7593	7593	A	G	MI.5190	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	8	3	H	R	cAt/cGt	2.14	0.97	0	probably_damaging	0.99	neutral	0.33	neutral	1.59	neutral	0.13	deleterious	-5.13	low_impact	1.7	0.51	damaging	0.21	damaging	1.57	13.71	neutral	0.7	0.75	NA	NA	0.36	neutral	0.33	neutral	0.16	neutral	7	0.99	deleterious	0.17	neutral	-2	neutral	0.76	deleterious	-2.58	low_impact	0.04	medium_impact	0.49	medium_impact	0.24	0.8	31.72	63.41	0.46	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7594	7594	T	G	MI.5191	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	9	3	H	Q	caT/caG	6.75	0.99	0	probably_damaging	1	neutral	0.29	neutral	1.59	neutral	0.21	deleterious	-4.56	low_impact	1.07	0.67	neutral	0.42	neutral	2.22	17.62	deleterious	0.76	0.8	NA	NA	0.18	neutral	0.23	neutral	0.22	neutral	6	1	deleterious	0.15	neutral	-2	neutral	0.70	deleterious	-3.52	low_impact	-0.01	medium_impact	-0.1	medium_impact	0.29	0.8	31.72	63.41	0.57	P	0.61	polymorphism	0.87	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7594	7594	T	A	MI.5192	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	9	3	H	Q	caT/caA	6.75	0.99	0	probably_damaging	1	neutral	0.29	neutral	1.59	neutral	0.21	deleterious	-4.56	low_impact	1.07	0.67	neutral	0.42	neutral	2.43	18.99	deleterious	0.76	0.8	NA	NA	0.18	neutral	0.23	neutral	0.22	neutral	6	1	deleterious	0.15	neutral	-2	neutral	0.70	deleterious	-3.52	low_impact	-0.01	medium_impact	-0.1	medium_impact	0.29	0.8	31.72	63.41	0.58	P	0.61	polymorphism	0.87	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7595	7595	G	A	MI.5193	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	10	4	A	T	Gca/Aca	-1.55	0	0	benign	0	neutral	0.4	neutral	1.57	neutral	-0.36	neutral	-0.1	low_impact	0.9	0.72	neutral	0.59	neutral	0.46	7.13	deleterious	0.5	0.6	NA	NA	0.15	neutral	0.35	neutral	0.26	neutral	5	0.6	neutral	0.7	deleterious	-6	neutral	0.15	neutral	2.08	high_impact	0.11	medium_impact	-0.26	medium_impact	0.62	0.8	67.4	12.96	0.44	N	0.55	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7595	7595	G	T	MI.5194	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	10	4	A	S	Gca/Tca	-1.55	0	0	benign	0.09	neutral	0.41	neutral	1.59	neutral	0.1	neutral	0.13	neutral_impact	-0.42	0.7	neutral	0.76	neutral	-0.07	1.99	neutral	0.36	0.5	NA	NA	0.17	neutral	0.18	neutral	0.25	neutral	5	0.53	neutral	0.66	deleterious	-6	neutral	0.20	neutral	0.22	medium_impact	0.12	medium_impact	-1.5	low_impact	0.55	0.8	67.4	12.96	0.52	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7595	7595	G	C	MI.5195	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	10	4	A	P	Gca/Cca	-1.55	0	0	benign	0	neutral	0.31	neutral	1.67	neutral	1.01	neutral	5.86	neutral_impact	-1.98	0.87	neutral	0.9	neutral	-0.94	0.02	neutral	0.28	0.45	NA	NA	0.12	neutral	0.15	neutral	0.24	neutral	5	0.69	neutral	0.66	deleterious	-6	neutral	0.17	neutral	2.08	high_impact	0.01	medium_impact	-2.96	low_impact	0.57	0.8	67.4	12.96	0.49	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7596	7596	C	A	MI.5196	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	11	4	A	E	gCa/gAa	3.52	0.88	0	benign	0.09	neutral	0.28	neutral	1.56	neutral	-0.4	neutral	-0.05	neutral_impact	0.55	0.64	neutral	0.59	neutral	2.35	18.48	deleterious	0.33	0.5	NA	NA	0.42	neutral	0.45	neutral	0.16	neutral	7	0.68	neutral	0.6	deleterious	-6	neutral	0.23	neutral	0.22	medium_impact	-0.02	medium_impact	-0.59	medium_impact	0.56	0.8	67.4	12.96	0.42	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7596	7596	C	T	MI.5197	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	11	4	A	V	gCa/gTa	3.52	0.88	0	benign	0.09	neutral	0.51	neutral	1.58	neutral	-0.06	neutral	-1.14	low_impact	0.9	0.69	neutral	0.72	neutral	1.36	12.56	neutral	0.4	0.5	NA	NA	0.22	neutral	0.36	neutral	0.15	neutral	7	0.42	neutral	0.71	deleterious	-6	neutral	0.19	neutral	0.22	medium_impact	0.21	medium_impact	-0.26	medium_impact	0.61	0.8	67.4	12.96	0.41	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7596	7596	C	G	MI.5198	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	11	4	A	G	gCa/gGa	3.52	0.88	0	benign	0.09	neutral	0.34	neutral	1.53	neutral	-1.42	neutral	-0.97	neutral_impact	0.55	0.65	neutral	0.62	neutral	0.82	9.56	deleterious	0.36	0.5	NA	NA	0.21	neutral	0.32	neutral	0.18	neutral	6	0.62	neutral	0.63	deleterious	-6	neutral	0.21	neutral	0.22	medium_impact	0.05	medium_impact	-0.59	medium_impact	0.71	0.85	67.4	12.96	0.46	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7598	7598	G	A	MI.5199	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	13	5	A	T	Gcg/Acg	-6.63	0	0.01	benign	0	neutral	0.56	neutral	1.54	neutral	-0.65	neutral	-0.14	low_impact	0.81	0.86	neutral	0.83	neutral	0.50	7.45	deleterious	0.67	0.7	NA	NA	0.15	neutral	0.3	neutral	0.24	neutral	5	0.44	neutral	0.78	deleterious	-6	neutral	0.09	neutral	2.08	high_impact	0.26	medium_impact	-0.35	medium_impact	0.73	0.85	32.16	66.12	0.4	N	0.31	polymorphism	1	0.01	rs386420012	.	.	.	.	.	.	.	.	G7598A	Possible LHON helper variant	-	+	Reported	2	N	P	N,P	neutral
chrM	8549	8549	C	G	MI.52	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	23	8	S	W	tCa/tGa	2.9	1	0	possibly_damaging	0.77	deleterious	0.03	neutral	4.57	deleterious	-4.19	deleterious	-3.29	low_impact	1.84	0.78	neutral	0.38	neutral	3.89	23.50	deleterious	0.23	0.65	0.94	disease	0.84	disease	0.52	disease	0.84	disease	7	0.98	neutral	0.13	neutral	1	deleterious	0.78	deleterious	-1.25	low_impact	-0.56	medium_impact	0.48	medium_impact	0.50	0.9	21.24	17.86	0.45	N	0.81	disease_causing	0.92	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8770	8770	A	C	MI.520	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	244	82	T	P	Act/Cct	-6.81	0	0	probably_damaging	1	neutral	0.06	neutral	4.31	neutral	-2.12	deleterious	-3.93	low_impact	1.94	0.77	neutral	0.09	damaging	2.25	17.82	deleterious	0.14	0.65	0.72	disease	0.75	disease	0.66	disease	0.73	disease	5	1	deleterious	0.03	neutral	-2	neutral	0.83	deleterious	-3.6	low_impact	-0.38	medium_impact	0.57	medium_impact	0.63	0.9	15.49	18.3	0.22	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7598	7598	G	T	MI.5200	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	13	5	A	S	Gcg/Tcg	-6.63	0	0.01	benign	0.07	neutral	0.91	neutral	1.58	neutral	-0.02	neutral	0.3	neutral_impact	-1	0.73	neutral	0.77	neutral	-0.97	0.02	neutral	0.49	0.55	NA	NA	0.04	neutral	0.2	neutral	0.19	neutral	6	0.03	neutral	0.92	deleterious	-6	neutral	0.11	neutral	0.33	medium_impact	0.76	medium_impact	-2.04	low_impact	0.81	0.85	32.16	66.12	0.35	N	0.34	polymorphism	1	0.00	rs386420012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7598	7598	G	C	MI.5201	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	13	5	A	P	Gcg/Ccg	-6.63	0	0.01	benign	0.3	neutral	0.26	neutral	1.48	neutral	-2.55	neutral	-2.37	low_impact	1.32	0.56	damaging	0.37	neutral	1.06	10.98	neutral	0.33	0.5	NA	NA	0.54	disease	0.46	neutral	0.49	neutral	0	0.69	neutral	0.48	deleterious	-6	neutral	0.34	neutral	-0.38	medium_impact	-0.05	medium_impact	0.13	medium_impact	0.87	0.9	32.16	66.12	0.34	N	0.57	polymorphism	1	0.07	rs386420012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7599	7599	C	G	MI.5202	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	14	5	A	G	gCg/gGg	-0.4	0	0	benign	0.07	neutral	0.5	neutral	1.53	neutral	-0.82	neutral	-1.98	neutral_impact	0.26	0.69	neutral	0.61	neutral	0.52	7.59	deleterious	0.46	0.55	NA	NA	0.16	neutral	0.27	neutral	0.23	neutral	5	0.44	neutral	0.72	deleterious	-6	neutral	0.15	neutral	0.33	medium_impact	0.21	medium_impact	-0.86	medium_impact	0.84	0.9	32.16	66.12	0.36	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7599	7599	C	A	MI.5203	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	14	5	A	E	gCg/gAg	-0.4	0	0	benign	0.11	neutral	0.55	neutral	1.52	neutral	-1.14	neutral	-1.98	low_impact	1.92	0.64	neutral	0.53	neutral	1.54	13.53	neutral	0.33	0.5	NA	NA	0.44	neutral	0.55	disease	0.41	neutral	2	0.36	neutral	0.72	deleterious	-6	neutral	0.23	neutral	0.13	medium_impact	0.25	medium_impact	0.7	medium_impact	0.66	0.8	32.16	66.12	0.31	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7599	7599	C	T	MI.5204	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	14	5	A	V	gCg/gTg	-0.4	0	0	benign	0	neutral	0.55	neutral	1.57	neutral	-0.19	neutral	-1.4	low_impact	1.92	0.83	neutral	0.75	neutral	1.08	11.12	neutral	0.51	0.6	NA	NA	0.24	neutral	0.48	neutral	0.19	neutral	6	0.45	neutral	0.78	deleterious	-6	neutral	0.11	neutral	2.08	high_impact	0.25	medium_impact	0.7	medium_impact	0.76	0.85	32.16	66.12	0.29	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7601	7601	C	A	MI.5205	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	16	6	Q	K	Caa/Aaa	-9.39	0	0	probably_damaging	1	neutral	0.33	neutral	1.44	neutral	-1.2	deleterious	-3.76	medium_impact	2.3	0.19	damaging	0.03	damaging	3.95	23.60	deleterious	0.59	0.65	NA	NA	0.44	neutral	0.54	disease	0.38	neutral	2	1	deleterious	0.17	neutral	1	deleterious	0.74	deleterious	-3.52	low_impact	0.04	medium_impact	1.05	medium_impact	0.68	0.85	68.28	15.91	0.7	P	0.84	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7601	7601	C	G	MI.5206	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	16	6	Q	E	Caa/Gaa	-9.39	0	0	probably_damaging	0.98	neutral	0.29	neutral	1.45	neutral	-0.97	deleterious	-2.74	medium_impact	2.61	0.33	damaging	0.35	neutral	3.01	22.30	deleterious	0.65	0.7	NA	NA	0.33	neutral	0.68	disease	0.41	neutral	2	0.99	deleterious	0.16	neutral	1	deleterious	0.72	deleterious	-2.3	low_impact	-0.01	medium_impact	1.34	medium_impact	0.71	0.85	68.28	15.91	0.58	P	0.28	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7602	7602	A	T	MI.5207	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	17	6	Q	L	cAa/cTa	2.83	0.98	0	probably_damaging	1	neutral	0.81	neutral	1.41	neutral	-2.79	deleterious	-6.65	medium_impact	2.52	0.29	damaging	0.05	damaging	3.86	23.50	deleterious	0.41	0.5	NA	NA	0.45	neutral	0.65	disease	0.47	neutral	1	1	deleterious	0.41	neutral	1	deleterious	0.73	deleterious	-3.52	low_impact	0.55	medium_impact	1.26	medium_impact	0.34	0.8	68.28	15.91	0.72	P	0.83	disease_causing	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7602	7602	A	G	MI.5208	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	17	6	Q	R	cAa/cGa	2.83	0.98	0	probably_damaging	1	neutral	0.35	neutral	1.41	neutral	-1.85	deleterious	-3.77	high_impact	3.96	0.21	damaging	0.06	damaging	3.48	23.10	deleterious	0.63	0.65	NA	NA	0.46	neutral	0.71	disease	0.49	neutral	0	1	deleterious	0.18	neutral	2	deleterious	0.76	deleterious	-3.52	low_impact	0.06	medium_impact	2.61	high_impact	0.50	0.8	68.28	15.91	0.84	P	0.71	disease_causing	0.8	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7602	7602	A	C	MI.5209	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	17	6	Q	P	cAa/cCa	2.83	0.98	0	probably_damaging	1	neutral	0.24	neutral	1.4	deleterious	-3.52	deleterious	-5.68	high_impact	3.96	0.15	damaging	0.03	damaging	3.39	23.00	deleterious	0.35	0.5	NA	NA	0.65	disease	0.67	disease	0.72	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-3.52	low_impact	-0.07	medium_impact	2.61	high_impact	0.51	0.8	68.28	15.91	0.82	P	0.79	disease_causing	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8770	8770	A	T	MI.521	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	244	82	T	S	Act/Tct	-6.81	0	0	probably_damaging	0.99	neutral	0.14	neutral	4.49	neutral	1.39	neutral	-2.31	neutral_impact	0.35	0.87	neutral	0.15	damaging	1.83	15.18	deleterious	0.44	0.65	0.31	neutral	0.24	neutral	0.37	neutral	0.42	neutral	2	0.99	deleterious	0.08	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	-0.15	medium_impact	-0.8	medium_impact	0.63	0.9	15.49	18.3	0.36	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7603	7603	A	C	MI.5210	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	18	6	Q	H	caA/caC	6.98	1	0	probably_damaging	1	neutral	0.55	neutral	1.39	deleterious	-3.23	deleterious	-4.71	medium_impact	2.77	0.35	damaging	0.2	damaging	3.41	23.00	deleterious	0.64	0.7	NA	NA	0.3	neutral	0.64	disease	0.38	neutral	2	1	deleterious	0.28	neutral	1	deleterious	0.72	deleterious	-3.52	low_impact	0.25	medium_impact	1.49	medium_impact	0.75	0.85	68.28	15.91	0.72	P	0.75	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7603	7603	A	T	MI.5211	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	18	6	Q	H	caA/caT	6.98	1	0	probably_damaging	1	neutral	0.55	neutral	1.39	deleterious	-3.23	deleterious	-4.71	medium_impact	2.77	0.35	damaging	0.2	damaging	3.56	23.10	deleterious	0.64	0.7	NA	NA	0.3	neutral	0.64	disease	0.38	neutral	2	1	deleterious	0.28	neutral	1	deleterious	0.72	deleterious	-3.52	low_impact	0.25	medium_impact	1.49	medium_impact	0.75	0.85	68.28	15.91	0.73	P	0.75	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7604	7604	G	C	MI.5212	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	19	7	V	L	Gta/Cta	3.29	0.99	0	benign	0	neutral	1	neutral	1.77	neutral	1.26	neutral	2.41	neutral_impact	-2.23	0.82	neutral	0.98	neutral	-1.09	0.01	neutral	0.47	0.55	NA	NA	0.06	neutral	0.19	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.08	high_impact	1.86	high_impact	-3.2	low_impact	0.42	0.8	61.67	18.86	0.42	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7604	7604	G	A	MI.5213	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	19	7	V	M	Gta/Ata	3.29	0.99	0	benign	0	neutral	0.11	neutral	1.62	neutral	-1.04	neutral	0.82	neutral_impact	-0.38	0.82	neutral	0.9	neutral	0.76	9.22	deleterious	0.49	0.55	NA	NA	0.15	neutral	0.21	neutral	0.24	neutral	5	0.89	neutral	0.56	deleterious	-6	neutral	0.13	neutral	2.08	high_impact	-0.3	medium_impact	-1.46	low_impact	0.73	0.85	61.67	18.86	0.54	P	0.49	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7604	7604	G	T	MI.5214	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	19	7	V	L	Gta/Tta	3.29	0.99	0	benign	0	neutral	1	neutral	1.77	neutral	1.26	neutral	2.41	neutral_impact	-2.23	0.82	neutral	0.98	neutral	-0.98	0.02	neutral	0.47	0.55	NA	NA	0.06	neutral	0.19	neutral	0.22	neutral	6	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.08	high_impact	1.86	high_impact	-3.2	low_impact	0.42	0.8	61.67	18.86	0.42	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7605	7605	T	G	MI.5215	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	20	7	V	G	gTa/gGa	-0.86	0.02	0	benign	0.14	neutral	0.13	neutral	1.49	neutral	-2.92	deleterious	-4.59	low_impact	1.82	0.64	neutral	0.54	neutral	2.13	17.05	deleterious	0.26	0.45	NA	NA	0.39	neutral	0.57	disease	0.35	neutral	3	0.85	neutral	0.5	deleterious	-6	neutral	0.29	neutral	0.01	medium_impact	-0.25	medium_impact	0.6	medium_impact	0.38	0.8	61.67	18.86	0.44	N	0.88	polymorphism	0.58	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7605	7605	T	A	MI.5216	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	20	7	V	E	gTa/gAa	-0.86	0.02	0	benign	0.14	neutral	0.11	neutral	1.49	neutral	-2.7	deleterious	-3.68	low_impact	1.82	0.63	neutral	0.53	neutral	3.22	22.70	deleterious	0.29	0.45	NA	NA	0.58	disease	0.7	disease	0.72	disease	4	0.87	neutral	0.49	deleterious	-6	neutral	0.36	neutral	0.01	medium_impact	-0.3	medium_impact	0.6	medium_impact	0.35	0.8	61.67	18.86	0.38	N	0.85	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7605	7605	T	C	MI.5217	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	20	7	V	A	gTa/gCa	-0.86	0.02	0	benign	0.05	neutral	0.2	neutral	1.55	neutral	-1.14	neutral	-1.87	low_impact	1.12	0.67	neutral	0.71	neutral	1.76	14.76	neutral	0.43	0.55	NA	NA	0.17	neutral	0.57	disease	0.28	neutral	4	0.79	neutral	0.58	deleterious	-6	neutral	0.16	neutral	0.47	medium_impact	-0.13	medium_impact	-0.06	medium_impact	0.29	0.8	61.67	18.86	0.48	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7607	7607	G	C	MI.5218	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	22	8	G	R	Ggt/Cgt	0.52	0.98	0	probably_damaging	0.92	neutral	0.37	neutral	1.53	neutral	-1.06	deleterious	-7.15	medium_impact	3.08	0.37	damaging	0.15	damaging	3.64	23.20	deleterious	0.32	0.5	NA	NA	0.8	disease	0.73	disease	0.77	disease	5	0.92	neutral	0.23	neutral	1	deleterious	0.81	deleterious	-1.71	low_impact	0.08	medium_impact	1.78	medium_impact	0.74	0.85	66.96	15.06	0.64	P	0.99	polymorphism	0.84	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7607	7607	G	T	MI.5219	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	22	8	G	C	Ggt/Tgt	0.52	0.98	0	probably_damaging	0.95	neutral	0.16	neutral	1.49	neutral	-2.99	deleterious	-8.22	high_impact	3.78	0.41	damaging	0.18	damaging	3.82	23.40	deleterious	0.28	0.45	NA	NA	0.79	disease	0.67	disease	0.74	disease	5	0.97	neutral	0.11	neutral	2	deleterious	0.77	deleterious	-1.91	low_impact	-0.19	medium_impact	2.44	high_impact	0.53	0.8	66.96	15.06	0.6	P	0.88	polymorphism	0.73	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8770	8770	A	G	MI.522	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	244	82	T	A	Act/Gct	-6.81	0	0	probably_damaging	0.99	neutral	0.23	neutral	4.48	neutral	1.42	deleterious	-2.67	neutral_impact	0.22	0.86	neutral	0.12	damaging	2.06	16.60	deleterious	0.55	0.65	0.26	neutral	0.24	neutral	0.49	neutral	0.43	neutral	1	0.99	deleterious	0.12	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	-0.01	medium_impact	-0.91	medium_impact	0.54	0.9	15.49	18.3	0.3	N	0.63	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7607	7607	G	A	MI.5220	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	22	8	G	S	Ggt/Agt	0.52	0.98	0	benign	0.06	neutral	0.67	neutral	1.56	neutral	-0.36	deleterious	-5.25	low_impact	1.37	0.55	damaging	0.43	neutral	0.93	10.28	neutral	0.46	0.55	NA	NA	0.38	neutral	0.36	neutral	0.17	neutral	7	0.25	neutral	0.81	deleterious	-6	neutral	0.16	neutral	0.39	medium_impact	0.38	medium_impact	0.18	medium_impact	0.60	0.8	66.96	15.06	0.44	N	0.38	polymorphism	0.92	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7608	7608	G	A	MI.5221	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	23	8	G	D	gGt/gAt	6.06	1	0	possibly_damaging	0.69	neutral	0.19	neutral	1.52	neutral	-1.35	deleterious	-6.16	medium_impact	2.5	0.38	damaging	0.17	damaging	3.44	23.00	deleterious	0.29	0.45	NA	NA	0.8	disease	0.71	disease	0.76	disease	5	0.84	neutral	0.25	neutral	0	NA	0.72	deleterious	-1.04	low_impact	-0.14	medium_impact	1.24	medium_impact	0.33	0.8	66.96	15.06	0.69	P	0.90	disease_causing	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7608	7608	G	T	MI.5222	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	23	8	G	V	gGt/gTt	6.06	1	0	possibly_damaging	0.89	neutral	0.5	neutral	1.56	neutral	-0.45	deleterious	-8.2	medium_impact	3.44	0.4	damaging	0.18	damaging	3.48	23.10	deleterious	0.3	0.45	NA	NA	0.73	disease	0.65	disease	0.71	disease	4	0.88	neutral	0.31	neutral	0	NA	0.75	deleterious	-1.57	low_impact	0.21	medium_impact	2.12	high_impact	0.37	0.8	66.96	15.06	0.68	P	0.96	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7608	7608	G	C	MI.5223	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	23	8	G	A	gGt/gCt	6.06	1	0	benign	0.19	neutral	0.55	neutral	1.57	neutral	-0.27	deleterious	-5.42	medium_impact	3.08	0.52	damaging	0.32	neutral	1.11	11.25	neutral	0.53	0.6	NA	NA	0.46	neutral	0.55	disease	0.43	neutral	1	0.34	neutral	0.68	deleterious	-3	neutral	0.43	neutral	-0.13	medium_impact	0.25	medium_impact	1.78	medium_impact	0.61	0.8	66.96	15.06	0.52	P	0.72	disease_causing	0.94	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7610	7610	C	G	MI.5224	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	25	9	L	V	Cta/Gta	-11.01	0	0	probably_damaging	0.99	neutral	0.22	neutral	0.99	deleterious	-3.37	neutral	-1.58	medium_impact	3.02	0.49	damaging	0.21	damaging	3.22	22.70	deleterious	0.42	0.55	NA	NA	0.61	disease	0.68	disease	0.7	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	-0.1	medium_impact	1.73	medium_impact	0.43	0.8	25.55	20.86	0.34	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7610	7610	C	A	MI.5225	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	25	9	L	M	Cta/Ata	-11.01	0	0	probably_damaging	1	neutral	0.11	neutral	1.07	neutral	-2.41	neutral	-0.62	low_impact	1.66	0.57	damaging	0.22	damaging	3.52	23.10	deleterious	0.32	0.5	NA	NA	0.49	neutral	0.35	neutral	0.4	neutral	2	1	deleterious	0.06	neutral	-2	neutral	0.76	deleterious	-3.52	low_impact	-0.3	medium_impact	0.45	medium_impact	0.68	0.85	25.55	20.86	0.41	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7611	7611	T	A	MI.5226	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	26	9	L	Q	cTa/cAa	1.21	0.87	0	probably_damaging	1	neutral	0.13	neutral	0.93	deleterious	-6.26	deleterious	-3.8	medium_impact	3.23	0.56	damaging	0.18	damaging	3.79	23.40	deleterious	0.19	0.45	NA	NA	0.79	disease	0.68	disease	0.72	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	-0.25	medium_impact	1.92	medium_impact	0.52	0.8	25.55	20.86	0.35	N	0.85	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7611	7611	T	G	MI.5227	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	26	9	L	R	cTa/cGa	1.21	0.87	0	probably_damaging	1	neutral	0.13	neutral	0.92	deleterious	-6.36	deleterious	-3.81	medium_impact	3.23	0.44	damaging	0.11	damaging	3.89	23.50	deleterious	0.18	0.45	NA	NA	0.89	disease	0.78	disease	0.82	disease	6	1	deleterious	0.07	neutral	1	deleterious	0.91	deleterious	-3.52	low_impact	-0.25	medium_impact	1.92	medium_impact	0.62	0.8	25.55	20.86	0.47	N	0.92	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7611	7611	T	C	MI.5228	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	26	9	L	P	cTa/cCa	1.21	0.87	0	probably_damaging	1	neutral	0.11	neutral	0.92	deleterious	-6.82	deleterious	-4.77	medium_impact	3.02	0.42	damaging	0.1	damaging	3.65	23.20	deleterious	0.16	0.45	NA	NA	0.87	disease	0.67	disease	0.75	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.89	deleterious	-3.52	low_impact	-0.3	medium_impact	1.73	medium_impact	0.45	0.8	25.55	20.86	0.41	N	0.95	polymorphism	0.95	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7613	7613	C	A	MI.5229	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	28	10	Q	K	Caa/Aaa	-8.47	0	0	probably_damaging	0.99	neutral	0.65	neutral	1.23	neutral	-2.33	deleterious	-3.89	high_impact	3.95	0.14	damaging	0.04	damaging	3.75	23.30	deleterious	0.52	0.6	NA	NA	0.82	disease	0.72	disease	0.74	disease	5	0.99	deleterious	0.33	neutral	2	deleterious	0.85	deleterious	-2.58	low_impact	0.35	medium_impact	2.6	high_impact	0.56	0.8	68.28	17.96	0.65	P	0.97	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8771	8771	C	A	MI.523	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	245	82	T	N	aCt/aAt	0.36	0.01	0	probably_damaging	1	neutral	0.32	neutral	4.35	neutral	1.39	deleterious	-3.12	neutral_impact	0.08	0.87	neutral	0.25	damaging	2.41	18.88	deleterious	0.53	0.65	0.28	neutral	0.21	neutral	0.35	neutral	0.35	neutral	3	1	deleterious	0.16	neutral	-2	neutral	0.67	deleterious	-3.6	low_impact	0.11	medium_impact	-1.03	low_impact	0.80	0.9	15.49	18.3	0.34	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7613	7613	C	G	MI.5230	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	28	10	Q	E	Caa/Gaa	-8.47	0	0	probably_damaging	0.98	neutral	0.68	neutral	1.22	neutral	-2.52	deleterious	-2.92	high_impact	3.95	0.15	damaging	0.05	damaging	2.93	22.00	deleterious	0.5	0.6	NA	NA	0.69	disease	0.72	disease	0.72	disease	4	0.98	deleterious	0.35	neutral	2	deleterious	0.83	deleterious	-2.3	low_impact	0.39	medium_impact	2.6	high_impact	0.61	0.8	68.28	17.96	0.64	P	0.85	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7614	7614	A	G	MI.5231	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	29	10	Q	R	cAa/cGa	5.6	1	0	probably_damaging	1	neutral	0.37	neutral	1.2	neutral	-2.93	deleterious	-3.89	high_impact	4.5	0.15	damaging	0.03	damaging	3.17	22.70	deleterious	0.58	0.65	NA	NA	0.82	disease	0.72	disease	0.74	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.08	medium_impact	3.11	high_impact	0.42	0.8	68.28	17.96	0.86	P	0.95	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7614	7614	A	C	MI.5232	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	29	10	Q	P	cAa/cCa	5.6	1	0	probably_damaging	1	neutral	0.25	neutral	1.2	neutral	-2.75	deleterious	-5.84	medium_impact	3.4	0.14	damaging	0.03	damaging	3.01	22.30	deleterious	0.23	0.45	NA	NA	0.84	disease	0.67	disease	0.75	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	-0.06	medium_impact	2.08	high_impact	0.49	0.8	68.28	17.96	0.86	P	0.95	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7614	7614	A	T	MI.5233	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	29	10	Q	L	cAa/cTa	5.6	1	0	probably_damaging	0.99	neutral	0.36	neutral	1.24	neutral	-2.12	deleterious	-6.82	medium_impact	2.93	0.2	damaging	0.03	damaging	3.45	23.00	deleterious	0.31	0.45	NA	NA	0.78	disease	0.64	disease	0.53	disease	1	0.99	deleterious	0.19	neutral	1	deleterious	0.83	deleterious	-2.58	low_impact	0.07	medium_impact	1.64	medium_impact	0.30	0.8	68.28	17.96	0.84	P	0.97	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7615	7615	A	T	MI.5234	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	30	10	Q	H	caA/caT	6.98	1	0	probably_damaging	1	neutral	0.14	neutral	1.16	deleterious	-4.19	deleterious	-4.87	high_impact	3.95	0.15	damaging	0.02	damaging	3.40	23.00	deleterious	0.49	0.55	NA	NA	0.72	disease	0.71	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.23	medium_impact	2.6	high_impact	0.48	0.8	68.28	17.96	0.89	P	0.86	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7615	7615	A	C	MI.5235	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	30	10	Q	H	caA/caC	6.98	1	0	probably_damaging	1	neutral	0.14	neutral	1.16	deleterious	-4.19	deleterious	-4.87	high_impact	3.95	0.15	damaging	0.02	damaging	3.23	22.80	deleterious	0.49	0.55	NA	NA	0.72	disease	0.71	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.23	medium_impact	2.6	high_impact	0.48	0.8	68.28	17.96	0.88	P	0.86	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7616	7616	G	A	MI.5236	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	31	11	D	N	Gac/Aac	3.98	1	0	probably_damaging	1	neutral	0.42	neutral	1.38	neutral	-1.26	deleterious	-4.13	low_impact	1.73	0.32	damaging	0.25	damaging	2.94	22.00	deleterious	0.75	0.8	NA	NA	0.56	disease	0.66	disease	0.45	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.76	deleterious	-3.52	low_impact	0.13	medium_impact	0.52	medium_impact	0.61	0.8	70.93	13.97	0.79	P	0.99	disease_causing	0.96	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7616	7616	G	C	MI.5237	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	31	11	D	H	Gac/Cac	3.98	1	0	probably_damaging	1	neutral	0.08	neutral	1.24	deleterious	-3.69	deleterious	-6.3	high_impact	4.02	0.5	damaging	0.02	damaging	3.41	23.00	deleterious	0.35	0.5	NA	NA	0.8	disease	0.8	disease	0.78	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	-0.38	medium_impact	2.66	high_impact	0.26	0.8	70.93	13.97	0.51	P	0.98	disease_causing	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7616	7616	G	T	MI.5238	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	31	11	D	Y	Gac/Tac	3.98	1	0	probably_damaging	1	neutral	0.07	neutral	1.23	deleterious	-4.29	deleterious	-8.32	medium_impact	3.47	0.32	damaging	0.02	damaging	3.68	23.30	deleterious	0.26	0.45	NA	NA	0.9	disease	0.8	disease	0.82	disease	6	1	deleterious	0.04	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	-0.42	medium_impact	2.15	high_impact	0.21	0.8	70.93	13.97	0.64	P	0.99	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7617	7617	A	T	MI.5239	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	32	11	D	V	gAc/gTc	9.29	1	0	probably_damaging	1	neutral	0.26	neutral	1.23	deleterious	-4.11	deleterious	-8.4	high_impact	4.02	0.38	damaging	0.02	damaging	3.47	23.00	deleterious	0.31	0.45	NA	NA	0.87	disease	0.79	disease	0.81	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	-0.05	medium_impact	2.66	high_impact	0.25	0.8	70.93	13.97	0.65	P	0.99	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8771	8771	C	T	MI.524	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	245	82	T	I	aCt/aTt	0.36	0.01	0	probably_damaging	1	neutral	0.92	neutral	4.41	neutral	0.09	neutral	-2.02	neutral_impact	-0.54	0.75	neutral	0.37	neutral	1.86	15.34	deleterious	0.48	0.65	0.42	neutral	0.25	neutral	0.38	neutral	0.43	neutral	1	0.99	deleterious	0.46	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.89	medium_impact	-1.56	low_impact	0.69	0.9	15.49	18.3	0.21	N	0.97	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7617	7617	A	G	MI.5240	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	32	11	D	G	gAc/gGc	9.29	1	0	probably_damaging	1	neutral	0.27	neutral	1.29	neutral	-2.28	deleterious	-6.38	high_impact	3.67	0.41	damaging	0.03	damaging	3.74	23.30	deleterious	0.3	0.45	NA	NA	0.82	disease	0.76	disease	0.76	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	-0.03	medium_impact	2.34	high_impact	0.26	0.8	70.93	13.97	0.68	P	0.97	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7617	7617	A	C	MI.5241	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	32	11	D	A	gAc/gCc	9.29	1	0	probably_damaging	1	neutral	0.45	neutral	1.28	neutral	-2.6	deleterious	-7.42	medium_impact	3.4	0.75	neutral	0.09	damaging	3.38	23.00	deleterious	0.29	0.45	NA	NA	0.75	disease	0.76	disease	0.74	disease	5	1	deleterious	0.23	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	0.16	medium_impact	2.08	high_impact	0.28	0.8	70.93	13.97	0.55	N	0.96	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7618	7618	C	A	MI.5242	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	33	11	D	E	gaC/gaA	8.59	1	0	probably_damaging	1	neutral	0.61	neutral	1.35	neutral	-1.47	deleterious	-3.67	medium_impact	2.52	0.27	damaging	0.03	damaging	4.00	23.60	deleterious	0.58	0.65	NA	NA	0.7	disease	0.67	disease	0.54	disease	1	1	deleterious	0.31	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.31	medium_impact	1.26	medium_impact	0.42	0.8	70.93	13.97	0.85	P	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7618	7618	C	G	MI.5243	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	33	11	D	E	gaC/gaG	8.59	1	0	probably_damaging	1	neutral	0.61	neutral	1.35	neutral	-1.47	deleterious	-3.67	medium_impact	2.52	0.27	damaging	0.03	damaging	3.66	23.20	deleterious	0.58	0.65	NA	NA	0.7	disease	0.67	disease	0.54	disease	1	1	deleterious	0.31	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.31	medium_impact	1.26	medium_impact	0.42	0.8	70.93	13.97	0.85	P	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7619	7619	G	A	MI.5244	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	34	12	A	T	Gct/Act	-5.01	0	0	benign	0.03	neutral	0.26	neutral	1.16	deleterious	-3.14	deleterious	-3.9	medium_impact	3.12	0.5	damaging	0.3	neutral	2.14	17.14	deleterious	0.57	0.65	NA	NA	0.72	disease	0.65	disease	0.7	disease	4	0.73	neutral	0.62	deleterious	-3	neutral	0.24	neutral	0.69	medium_impact	-0.05	medium_impact	1.82	medium_impact	0.65	0.8	68.28	17.75	0.37	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7619	7619	G	T	MI.5245	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	34	12	A	S	Gct/Tct	-5.01	0	0	possibly_damaging	0.47	neutral	0.74	neutral	1.62	neutral	0.13	deleterious	-2.92	low_impact	1.2	0.52	damaging	0.36	neutral	1.92	15.74	deleterious	0.51	0.6	NA	NA	0.14	neutral	0.27	neutral	0.23	neutral	5	0.36	neutral	0.64	deleterious	-3	neutral	0.36	neutral	-0.67	medium_impact	0.46	medium_impact	0.02	medium_impact	0.67	0.85	68.28	17.75	0.32	N	0.71	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7619	7619	G	C	MI.5246	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	34	12	A	P	Gct/Cct	-5.01	0	0	possibly_damaging	0.82	neutral	0.27	neutral	1.14	deleterious	-3.41	deleterious	-4.87	low_impact	1.86	0.36	damaging	0.3	neutral	3.53	23.10	deleterious	0.19	0.45	NA	NA	0.89	disease	0.49	neutral	0.67	disease	3	0.87	neutral	0.23	neutral	-3	neutral	0.83	deleterious	-1.33	low_impact	-0.03	medium_impact	0.64	medium_impact	0.73	0.85	68.28	17.75	0.47	N	0.90	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7620	7620	C	T	MI.5247	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	35	12	A	V	gCt/gTt	5.13	1	0	benign	0.35	neutral	0.2	neutral	1.13	deleterious	-4.02	deleterious	-3.9	medium_impact	3.47	0.45	damaging	0.28	neutral	2.51	19.54	deleterious	0.37	0.5	NA	NA	0.78	disease	0.63	disease	0.73	disease	5	0.76	neutral	0.43	neutral	-3	neutral	0.63	deleterious	-0.47	medium_impact	-0.13	medium_impact	2.15	high_impact	0.67	0.85	68.28	17.75	0.56	P	0.79	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7620	7620	C	A	MI.5248	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	35	12	A	D	gCt/gAt	5.13	1	0	possibly_damaging	0.78	neutral	0.15	neutral	1.12	deleterious	-4.45	deleterious	-5.85	high_impact	3.67	0.38	damaging	0.31	neutral	4.11	23.70	deleterious	0.25	0.45	NA	NA	0.9	disease	0.69	disease	0.78	disease	6	0.9	neutral	0.19	neutral	1	deleterious	0.80	deleterious	-1.23	low_impact	-0.21	medium_impact	2.34	high_impact	0.41	0.8	68.28	17.75	0.72	P	0.94	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7620	7620	C	G	MI.5249	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	35	12	A	G	gCt/gGt	5.13	1	0	benign	0.24	neutral	0.3	neutral	1.22	neutral	-2.09	deleterious	-3.9	medium_impact	2.16	0.43	damaging	0.44	neutral	2.00	16.23	deleterious	0.43	0.55	NA	NA	0.66	disease	0.36	neutral	0.48	neutral	0	0.64	neutral	0.53	deleterious	-3	neutral	0.44	deleterious	-0.25	medium_impact	0	medium_impact	0.92	medium_impact	0.71	0.85	68.28	17.75	0.66	P	0.74	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8771	8771	C	G	MI.525	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	245	82	T	S	aCt/aGt	0.36	0.01	0	probably_damaging	0.99	neutral	0.14	neutral	4.49	neutral	1.39	neutral	-2.31	neutral_impact	0.35	0.87	neutral	0.15	damaging	1.97	16.05	deleterious	0.44	0.65	0.31	neutral	0.24	neutral	0.37	neutral	0.42	neutral	2	0.99	deleterious	0.08	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	-0.15	medium_impact	-0.8	medium_impact	0.63	0.9	15.49	18.3	0.36	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7622	7622	A	T	MI.5250	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	37	13	T	S	Act/Tct	-1.09	0	0	probably_damaging	0.99	neutral	0.76	neutral	1.78	neutral	1.63	neutral	-0.41	neutral_impact	-0.38	0.72	neutral	0.62	neutral	0.07	3.26	deleterious	0.49	0.55	NA	NA	0.23	neutral	0.21	neutral	0.17	neutral	7	0.99	deleterious	0.39	neutral	-2	neutral	0.71	deleterious	-2.58	low_impact	0.48	medium_impact	-1.46	low_impact	0.44	0.8	70.04	13.93	0.32	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7622	7622	A	G	MI.5251	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	37	13	T	A	Act/Gct	-1.09	0	0	probably_damaging	0.99	neutral	1	neutral	2.06	neutral	2.77	neutral	0.72	neutral_impact	-1.58	0.77	neutral	0.71	neutral	-1.38	0.00	neutral	0.48	0.55	NA	NA	0.06	neutral	0.23	neutral	0.19	neutral	6	0.99	deleterious	0.51	deleterious	-2	neutral	0.65	deleterious	-2.58	low_impact	1.86	high_impact	-2.59	low_impact	0.33	0.8	70.04	13.93	0.27	N	0.87	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7622	7622	A	C	MI.5252	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	37	13	T	P	Act/Cct	-1.09	0	0	probably_damaging	1	neutral	0.22	neutral	1.51	neutral	-2.08	neutral	-2.41	medium_impact	2.06	0.38	damaging	0.13	damaging	3.23	22.80	deleterious	0.18	0.45	NA	NA	0.82	disease	0.49	neutral	0.73	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	-0.1	medium_impact	0.83	medium_impact	0.35	0.8	70.04	13.93	0.45	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7623	7623	C	A	MI.5253	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	38	13	T	N	aCt/aAt	-0.17	0	0	probably_damaging	1	neutral	0.58	neutral	1.62	neutral	0.46	deleterious	-2.54	neutral_impact	0	0.54	damaging	0.17	damaging	3.26	22.80	deleterious	0.47	0.55	NA	NA	0.54	disease	0.25	neutral	0.44	neutral	1	1	deleterious	0.29	neutral	-2	neutral	0.75	deleterious	-3.52	low_impact	0.28	medium_impact	-1.11	low_impact	0.56	0.8	70.04	13.93	0.28	N	0.82	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7623	7623	C	T	MI.5254	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	38	13	T	I	aCt/aTt	-0.17	0	0	probably_damaging	1	neutral	0.32	neutral	1.51	neutral	-2.14	neutral	-1.96	low_impact	1.31	0.53	damaging	0.2	damaging	3.64	23.20	deleterious	0.31	0.45	NA	NA	0.59	disease	0.29	neutral	0.48	neutral	0	1	deleterious	0.16	neutral	-2	neutral	0.77	deleterious	-3.52	low_impact	0.02	medium_impact	0.12	medium_impact	0.49	0.8	70.04	13.93	0.46	N	0.84	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	C7623T	LHON	+	-	Reported	1	.	P	P	neutral
chrM	7623	7623	C	G	MI.5255	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	38	13	T	S	aCt/aGt	-0.17	0	0	probably_damaging	0.99	neutral	0.76	neutral	1.78	neutral	1.63	neutral	-0.41	neutral_impact	-0.38	0.72	neutral	0.62	neutral	0.23	5.04	deleterious	0.49	0.55	NA	NA	0.23	neutral	0.21	neutral	0.17	neutral	7	0.99	deleterious	0.39	neutral	-2	neutral	0.71	deleterious	-2.58	low_impact	0.48	medium_impact	-1.46	low_impact	0.44	0.8	70.04	13.93	0.31	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7625	7625	T	C	MI.5256	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	40	14	S	P	Tcc/Ccc	-3.86	0	0	probably_damaging	1	neutral	0.16	neutral	0.52	deleterious	-6.15	deleterious	-4.88	high_impact	3.92	0.3	damaging	0.34	neutral	3.81	23.40	deleterious	0.24	0.45	NA	NA	0.83	disease	0.71	disease	0.75	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.19	medium_impact	2.57	high_impact	0.52	0.8	68.28	17.25	0.57	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7625	7625	T	A	MI.5257	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	40	14	S	T	Tcc/Acc	-3.86	0	0	probably_damaging	0.99	neutral	0.06	neutral	0.72	neutral	-2.74	deleterious	-2.93	low_impact	1.92	0.32	damaging	0.37	neutral	3.60	23.20	deleterious	0.44	0.55	NA	NA	0.66	disease	0.61	disease	0.57	disease	1	1	deleterious	0.04	neutral	-2	neutral	0.79	deleterious	-2.58	low_impact	-0.46	medium_impact	0.7	medium_impact	0.71	0.85	68.28	17.25	0.6	P	0.53	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7625	7625	T	G	MI.5258	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	40	14	S	A	Tcc/Gcc	-3.86	0	0	probably_damaging	0.99	neutral	0.15	neutral	0.6	deleterious	-3.88	deleterious	-2.92	medium_impact	3.38	0.34	damaging	0.42	neutral	3.53	23.10	deleterious	0.43	0.55	NA	NA	0.56	disease	0.65	disease	0.55	disease	1	1	deleterious	0.08	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	-0.21	medium_impact	2.06	high_impact	0.64	0.8	68.28	17.25	0.59	P	0.36	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7626	7626	C	G	MI.5259	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	41	14	S	C	tCc/tGc	5.83	1	0	probably_damaging	1	deleterious	0	neutral	0.51	deleterious	-6.77	deleterious	-4.88	high_impact	3.67	0.31	damaging	0.33	neutral	3.41	23.00	deleterious	0.32	0.5	NA	NA	0.77	disease	0.66	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.52	low_impact	-1.45	low_impact	2.34	high_impact	0.61	0.8	68.28	17.25	0.7	P	0.91	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8773	8773	A	C	MI.526	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	247	83	N	H	Aac/Cac	-9.59	0	0	probably_damaging	1	deleterious	0.01	neutral	2.79	deleterious	-8.45	deleterious	-4.6	high_impact	4.65	0.61	neutral	0.3	neutral	2.97	22.10	deleterious	0.35	0.65	0.99	disease	0.86	disease	0.76	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-0.84	medium_impact	2.89	high_impact	0.44	0.9	49.12	8.61	0.47	N	0.98	disease_causing	0.53	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7626	7626	C	A	MI.5260	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	41	14	S	Y	tCc/tAc	5.83	1	0	probably_damaging	1	deleterious	0	neutral	0.5	deleterious	-7.54	deleterious	-5.86	high_impact	4.47	0.29	damaging	0.26	damaging	3.86	23.50	deleterious	0.23	0.45	NA	NA	0.84	disease	0.74	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.52	low_impact	-1.45	low_impact	3.09	high_impact	0.62	0.8	68.28	17.25	0.87	P	1.00	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7626	7626	C	T	MI.5261	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	41	14	S	F	tCc/tTc	5.83	1	0	probably_damaging	1	neutral	0.06	neutral	0.5	deleterious	-7.31	deleterious	-5.86	high_impact	4.47	0.31	damaging	0.28	damaging	4.05	23.70	deleterious	0.22	0.45	NA	NA	0.86	disease	0.74	disease	0.78	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.46	medium_impact	3.09	high_impact	0.39	0.8	68.28	17.25	0.74	P	0.99	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7628	7628	C	G	MI.5262	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	43	15	P	A	Cct/Gct	-8.24	0	0	probably_damaging	0.98	neutral	0.2	neutral	1.35	neutral	-1.5	deleterious	-7.85	high_impact	3.94	0.32	damaging	0.43	neutral	2.87	21.70	deleterious	0.37	0.5	NA	NA	0.66	disease	0.62	disease	0.66	disease	3	0.99	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-2.3	low_impact	-0.13	medium_impact	2.59	high_impact	0.78	0.85	68.72	18.24	0.61	P	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7628	7628	C	A	MI.5263	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	43	15	P	T	Cct/Act	-8.24	0	0	probably_damaging	1	neutral	0.08	neutral	1.27	neutral	-2.6	deleterious	-7.84	high_impact	3.68	0.31	damaging	0.29	neutral	3.56	23.10	deleterious	0.36	0.5	NA	NA	0.81	disease	0.61	disease	0.69	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.38	medium_impact	2.35	high_impact	0.64	0.8	68.72	18.24	0.54	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7628	7628	C	T	MI.5264	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	43	15	P	S	Cct/Tct	-8.24	0	0	probably_damaging	1	neutral	0.2	neutral	1.28	neutral	-2.38	deleterious	-7.84	medium_impact	2.79	0.34	damaging	0.36	neutral	3.71	23.30	deleterious	0.51	0.6	NA	NA	0.79	disease	0.55	disease	0.49	neutral	0	1	deleterious	0.1	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	-0.13	medium_impact	1.51	medium_impact	0.26	0.8	68.72	18.24	0.48	N	0.94	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7629	7629	C	G	MI.5265	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	44	15	P	R	cCt/cGt	5.6	1	0	probably_damaging	1	neutral	0.1	neutral	1.24	deleterious	-3.21	deleterious	-8.83	high_impact	4.14	0.28	damaging	0.33	neutral	3.40	23.00	deleterious	0.31	0.5	NA	NA	0.89	disease	0.72	disease	0.77	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.32	medium_impact	2.78	high_impact	0.47	0.8	68.72	18.24	0.89	P	0.85	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7629	7629	C	T	MI.5266	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	44	15	P	L	cCt/cTt	5.6	1	0	probably_damaging	1	neutral	0.1	neutral	1.33	neutral	-1.67	deleterious	-9.81	high_impact	3.52	0.29	damaging	0.44	neutral	4.11	23.70	deleterious	0.44	0.55	NA	NA	0.84	disease	0.61	disease	0.71	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.32	medium_impact	2.2	high_impact	0.73	0.85	68.72	18.24	0.86	P	0.92	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7629	7629	C	A	MI.5267	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	44	15	P	H	cCt/cAt	5.6	1	0	probably_damaging	1	deleterious	0.03	neutral	1.22	deleterious	-4.11	deleterious	-8.83	high_impact	3.79	0.28	damaging	0.33	neutral	3.73	23.30	deleterious	0.31	0.45	NA	NA	0.85	disease	0.64	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-3.52	low_impact	-0.63	medium_impact	2.45	high_impact	0.55	0.8	68.72	18.24	0.89	P	0.79	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7631	7631	A	T	MI.5268	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	46	16	I	F	Atc/Ttc	-9.62	0	0	possibly_damaging	0.53	neutral	0.59	neutral	1.45	neutral	-2.3	deleterious	-3.62	medium_impact	2.36	0.49	damaging	0.3	neutral	3.38	22.90	deleterious	0.52	0.6	NA	NA	0.62	disease	0.64	disease	0.71	disease	4	0.48	neutral	0.53	deleterious	0	NA	0.58	deleterious	-0.77	medium_impact	0.29	medium_impact	1.11	medium_impact	0.63	0.8	68.28	13.53	0.33	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7631	7631	A	G	MI.5269	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	46	16	I	V	Atc/Gtc	-9.62	0	0	benign	0	neutral	0.73	neutral	1.56	neutral	-0.56	neutral	-0.79	neutral_impact	0.73	0.9	neutral	0.87	neutral	-0.97	0.02	neutral	0.62	0.65	NA	NA	0.17	neutral	0.32	neutral	0.22	neutral	6	0.26	neutral	0.87	deleterious	-6	neutral	0.10	neutral	2.08	high_impact	0.44	medium_impact	-0.42	medium_impact	0.52	0.8	68.28	13.53	0.36	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8773	8773	A	G	MI.527	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	247	83	N	D	Aac/Gac	-9.59	0	0	probably_damaging	0.99	deleterious	0.01	neutral	2.81	deleterious	-7.2	deleterious	-4.6	high_impact	4.65	0.55	damaging	0.36	neutral	3.78	23.40	deleterious	0.46	0.65	0.97	disease	0.81	disease	0.8	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-0.84	medium_impact	2.89	high_impact	0.49	0.9	49.12	8.61	0.49	N	0.97	polymorphism	0.65	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7631	7631	A	C	MI.5270	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	46	16	I	L	Atc/Ctc	-9.62	0	0	benign	0.07	neutral	1	neutral	1.6	neutral	-0.61	neutral	-1.35	neutral_impact	0.63	0.72	neutral	0.77	neutral	-0.11	1.64	neutral	0.45	0.55	NA	NA	0.12	neutral	0.2	neutral	0.23	neutral	5	0.07	neutral	0.97	deleterious	-6	neutral	0.10	neutral	0.33	medium_impact	1.86	high_impact	-0.52	medium_impact	0.68	0.85	68.28	13.53	0.32	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7632	7632	T	A	MI.5271	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	47	16	I	N	aTc/aAc	2.14	0.97	0	probably_damaging	0.94	neutral	0.29	neutral	1.44	neutral	-2.39	deleterious	-6.46	medium_impact	2.23	0.53	damaging	0.31	neutral	4.12	23.80	deleterious	0.44	0.55	NA	NA	0.74	disease	0.67	disease	0.73	disease	5	0.95	neutral	0.18	neutral	1	deleterious	0.77	deleterious	-1.83	low_impact	-0.01	medium_impact	0.99	medium_impact	0.42	0.8	68.28	13.53	0.38	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7632	7632	T	G	MI.5272	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	47	16	I	S	aTc/aGc	2.14	0.97	0	possibly_damaging	0.78	neutral	0.35	neutral	1.45	neutral	-1.69	deleterious	-5.48	medium_impact	2.06	0.55	damaging	0.38	neutral	3.88	23.50	deleterious	0.39	0.5	NA	NA	0.7	disease	0.57	disease	0.67	disease	3	0.8	neutral	0.29	neutral	0	NA	0.64	deleterious	-1.23	low_impact	0.06	medium_impact	0.83	medium_impact	0.41	0.8	68.28	13.53	0.41	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7632	7632	T	C	MI.5273	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	47	16	I	T	aTc/aCc	2.14	0.97	0	possibly_damaging	0.51	neutral	0.49	neutral	1.48	neutral	-1.41	deleterious	-4.41	low_impact	1.76	0.66	neutral	0.37	neutral	1.57	13.70	neutral	0.55	0.6	NA	NA	0.48	neutral	0.44	neutral	0.33	neutral	3	0.52	neutral	0.49	deleterious	-3	neutral	0.46	deleterious	-0.74	medium_impact	0.2	medium_impact	0.55	medium_impact	0.46	0.8	68.28	13.53	0.42	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7633	7633	C	G	MI.5274	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	48	16	I	M	atC/atG	5.83	0.99	0	possibly_damaging	0.78	neutral	0.3	neutral	1.45	neutral	-1.94	neutral	-2.39	low_impact	1.39	0.65	neutral	0.4	neutral	1.86	15.35	deleterious	0.64	0.7	NA	NA	0.35	neutral	0.32	neutral	0.17	neutral	7	0.82	neutral	0.26	neutral	-3	neutral	0.53	deleterious	-1.23	low_impact	0	medium_impact	0.2	medium_impact	0.68	0.85	68.28	13.53	0.56	P	0.79	polymorphism	1	0.05	rs386829011	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7633	7633	C	A	MI.5275	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	48	16	I	M	atC/atA	5.83	0.99	0	possibly_damaging	0.78	neutral	0.3	neutral	1.45	neutral	-1.94	neutral	-2.39	low_impact	1.39	0.65	neutral	0.4	neutral	2.39	18.75	deleterious	0.64	0.7	NA	NA	0.35	neutral	0.32	neutral	0.17	neutral	7	0.82	neutral	0.26	neutral	-3	neutral	0.53	deleterious	-1.23	low_impact	0	medium_impact	0.2	medium_impact	0.68	0.85	68.28	13.53	0.56	P	0.79	polymorphism	1	0.05	rs386829011	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7634	7634	A	C	MI.5276	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	49	17	M	L	Ata/Cta	-3.4	0	0	probably_damaging	0.95	neutral	0.28	neutral	1.42	neutral	-1.31	deleterious	-2.93	high_impact	3.53	0.3	damaging	0.38	neutral	3.15	22.60	deleterious	0.46	0.55	NA	NA	0.74	disease	0.64	disease	0.67	disease	3	0.96	neutral	0.17	neutral	2	deleterious	0.80	deleterious	-1.91	low_impact	-0.02	medium_impact	2.2	high_impact	0.58	0.8	68.28	18.34	0.62	P	0.70	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7634	7634	A	G	MI.5277	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	49	17	M	V	Ata/Gta	-3.4	0	0	probably_damaging	0.97	neutral	0.18	neutral	1.39	neutral	-1.83	deleterious	-3.91	high_impact	3.96	0.3	damaging	0.26	damaging	2.65	20.50	deleterious	0.43	0.55	NA	NA	0.78	disease	0.71	disease	0.73	disease	5	0.98	neutral	0.11	neutral	2	deleterious	0.82	deleterious	-2.13	low_impact	-0.16	medium_impact	2.61	high_impact	0.50	0.8	68.28	18.34	0.65	P	0.89	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7634	7634	A	T	MI.5278	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	49	17	M	L	Ata/Tta	-3.4	0	0	probably_damaging	0.95	neutral	0.28	neutral	1.42	neutral	-1.31	deleterious	-2.93	high_impact	3.53	0.3	damaging	0.38	neutral	3.22	22.70	deleterious	0.46	0.55	NA	NA	0.74	disease	0.64	disease	0.67	disease	3	0.96	neutral	0.17	neutral	2	deleterious	0.80	deleterious	-1.91	low_impact	-0.02	medium_impact	2.2	high_impact	0.58	0.8	68.28	18.34	0.63	P	0.70	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7635	7635	T	C	MI.5279	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	50	17	M	T	aTa/aCa	6.98	1	0	probably_damaging	1	neutral	0.21	neutral	1.37	neutral	-2.22	deleterious	-5.85	high_impact	3.96	0.31	damaging	0.31	neutral	2.79	21.30	deleterious	0.33	0.5	NA	NA	0.84	disease	0.68	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.11	medium_impact	2.61	high_impact	0.32	0.8	68.28	18.34	0.75	P	0.92	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8773	8773	A	T	MI.528	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	247	83	N	Y	Aac/Tac	-9.59	0	0	probably_damaging	1	deleterious	0	neutral	2.79	deleterious	-8.43	deleterious	-7.37	high_impact	4.65	0.49	damaging	0.29	neutral	3.63	23.20	deleterious	0.25	0.65	0.99	disease	0.9	disease	0.75	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.89	high_impact	0.39	0.9	49.12	8.61	0.43	N	1.00	disease_causing	0.82	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7635	7635	T	A	MI.5280	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	50	17	M	K	aTa/aAa	6.98	1	0	probably_damaging	1	neutral	0.29	neutral	1.35	neutral	-2.7	deleterious	-5.87	medium_impact	3.31	0.32	damaging	0.26	damaging	3.82	23.40	deleterious	0.19	0.45	NA	NA	0.86	disease	0.76	disease	0.78	disease	6	1	deleterious	0.15	neutral	1	deleterious	0.90	deleterious	-3.52	low_impact	-0.01	medium_impact	2	medium_impact	0.32	0.8	68.28	18.34	0.77	P	1.00	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7636	7636	A	C	MI.5281	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	51	17	M	I	atA/atC	7.44	1	0	probably_damaging	0.98	neutral	0.17	neutral	1.38	neutral	-2.02	deleterious	-3.91	high_impact	3.81	0.3	damaging	0.4	neutral	3.24	22.80	deleterious	0.45	0.55	NA	NA	0.8	disease	0.7	disease	0.73	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.3	low_impact	-0.18	medium_impact	2.47	high_impact	0.74	0.85	68.28	18.34	0.81	P	0.78	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7636	7636	A	T	MI.5282	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	51	17	M	I	atA/atT	7.44	1	0	probably_damaging	0.98	neutral	0.17	neutral	1.38	neutral	-2.02	deleterious	-3.91	high_impact	3.81	0.3	damaging	0.4	neutral	3.32	22.90	deleterious	0.45	0.55	NA	NA	0.8	disease	0.7	disease	0.73	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.3	low_impact	-0.18	medium_impact	2.47	high_impact	0.74	0.85	68.28	18.34	0.83	P	0.78	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7637	7637	G	C	MI.5283	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	52	18	E	Q	Gaa/Caa	1.91	1	0	probably_damaging	0.99	neutral	0.33	neutral	1.27	neutral	-2.21	deleterious	-2.94	medium_impact	2.69	0.3	damaging	0.33	neutral	3.10	22.50	deleterious	0.4	0.5	NA	NA	0.73	disease	0.49	neutral	0.51	disease	0	0.99	deleterious	0.17	neutral	1	deleterious	0.82	deleterious	-2.58	low_impact	0.04	medium_impact	1.42	medium_impact	0.64	0.8	68.72	18.52	0.74	P	0.76	disease_causing	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7637	7637	G	A	MI.5284	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	52	18	E	K	Gaa/Aaa	1.91	1	0	probably_damaging	0.99	neutral	0.25	neutral	1.29	neutral	-1.93	deleterious	-3.92	high_impact	3.91	0.29	damaging	0.15	damaging	4.31	24.00	deleterious	0.28	0.45	NA	NA	0.84	disease	0.58	disease	0.7	disease	4	0.99	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-2.58	low_impact	-0.06	medium_impact	2.56	high_impact	0.62	0.8	68.72	18.52	0.91	P	0.99	disease_causing	0.99	0.10	.	Uncertain_significance	not_specified	433703	MedGen:CN169374	.	.	.	.	G7637A	PD risk factor	-	+	Reported	1	.	P	P	damaging
chrM	7638	7638	A	C	MI.5285	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	53	18	E	A	gAa/gCa	9.05	1	0	probably_damaging	1	neutral	0.47	neutral	1.26	neutral	-2.37	deleterious	-5.89	high_impact	3.56	0.34	damaging	0.36	neutral	3.39	23.00	deleterious	0.25	0.45	NA	NA	0.66	disease	0.62	disease	0.66	disease	3	0.99	deleterious	0.24	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	0.18	medium_impact	2.23	high_impact	0.50	0.8	68.72	18.52	0.76	P	0.66	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7638	7638	A	G	MI.5286	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	53	18	E	G	gAa/gGa	9.05	1	0	probably_damaging	1	neutral	0.28	neutral	1.21	deleterious	-3.51	deleterious	-6.86	high_impact	3.56	0.26	damaging	0.42	neutral	4.02	23.60	deleterious	0.31	0.45	NA	NA	0.77	disease	0.65	disease	0.68	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	-0.02	medium_impact	2.23	high_impact	0.36	0.8	68.72	18.52	0.91	P	0.64	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7638	7638	A	T	MI.5287	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	53	18	E	V	gAa/gTa	9.05	1	0	probably_damaging	1	neutral	0.48	neutral	1.2	deleterious	-3.64	deleterious	-6.87	high_impact	3.56	0.26	damaging	0.26	damaging	3.90	23.50	deleterious	0.25	0.45	NA	NA	0.85	disease	0.65	disease	0.73	disease	5	1	deleterious	0.24	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.19	medium_impact	2.23	high_impact	0.44	0.8	68.72	18.52	0.9	P	0.82	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7639	7639	A	T	MI.5288	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	54	18	E	D	gaA/gaT	8.59	1	0	probably_damaging	0.97	neutral	0.25	neutral	1.28	neutral	-2.03	deleterious	-2.93	medium_impact	2.56	0.3	damaging	0.3	neutral	3.62	23.20	deleterious	0.38	0.5	NA	NA	0.71	disease	0.55	disease	0.64	disease	3	0.98	neutral	0.14	neutral	1	deleterious	0.81	deleterious	-2.13	low_impact	-0.06	medium_impact	1.3	medium_impact	0.48	0.8	68.72	18.52	0.81	P	0.81	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7639	7639	A	C	MI.5289	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	54	18	E	D	gaA/gaC	8.59	1	0	probably_damaging	0.97	neutral	0.25	neutral	1.28	neutral	-2.03	deleterious	-2.93	medium_impact	2.56	0.3	damaging	0.3	neutral	3.49	23.10	deleterious	0.38	0.5	NA	NA	0.71	disease	0.55	disease	0.64	disease	3	0.98	neutral	0.14	neutral	1	deleterious	0.81	deleterious	-2.13	low_impact	-0.06	medium_impact	1.3	medium_impact	0.48	0.8	68.72	18.52	0.81	P	0.81	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8774	8774	A	T	MI.529	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	248	83	N	I	aAc/aTc	8.46	1	0	probably_damaging	1	deleterious	0	neutral	2.8	deleterious	-7.69	deleterious	-8.29	high_impact	4.65	0.56	damaging	0.47	neutral	3.82	23.40	deleterious	0.21	0.65	0.98	disease	0.92	disease	0.71	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.89	high_impact	0.39	0.9	49.12	8.61	0.52	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7640	7640	G	C	MI.5290	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	55	19	E	Q	Gag/Cag	2.6	1	0	probably_damaging	0.99	neutral	0.66	neutral	1.57	neutral	-0.12	deleterious	-2.95	neutral_impact	0.39	0.42	damaging	0.03	damaging	1.85	15.30	deleterious	0.4	0.5	NA	NA	0.07	neutral	0.16	neutral	0.23	neutral	5	0.98	deleterious	0.34	neutral	-2	neutral	0.70	deleterious	-2.58	low_impact	0.36	medium_impact	-0.74	medium_impact	0.64	0.8	68.72	18.75	0.5	P	0.76	disease_causing	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7640	7640	G	A	MI.5291	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	55	19	E	K	Gag/Aag	2.6	1	0	probably_damaging	0.98	neutral	0.25	neutral	1.57	neutral	-0.14	deleterious	-3.93	medium_impact	2.9	0.27	damaging	0.03	damaging	4.32	24.00	deleterious	0.28	0.45	NA	NA	0.76	disease	0.57	disease	0.71	disease	4	0.99	deleterious	0.14	neutral	1	deleterious	0.85	deleterious	-2.3	low_impact	-0.06	medium_impact	1.61	medium_impact	0.56	0.8	68.72	18.75	0.84	P	0.99	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7641	7641	A	C	MI.5292	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	56	19	E	A	gAg/gCg	9.29	1	0	probably_damaging	0.99	neutral	0.43	neutral	1.49	neutral	-1.08	deleterious	-5.89	medium_impact	2.79	0.38	damaging	0.11	damaging	3.39	23.00	deleterious	0.25	0.45	NA	NA	0.52	disease	0.56	disease	0.66	disease	3	0.99	deleterious	0.22	neutral	1	deleterious	0.77	deleterious	-2.58	low_impact	0.14	medium_impact	1.51	medium_impact	0.65	0.8	68.72	18.75	0.67	P	0.66	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7641	7641	A	T	MI.5293	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	56	19	E	V	gAg/gTg	9.29	1	0	probably_damaging	0.99	neutral	0.46	neutral	1.43	neutral	-2.38	deleterious	-6.88	medium_impact	3.25	0.33	damaging	0.03	damaging	3.95	23.60	deleterious	0.22	0.45	NA	NA	0.76	disease	0.59	disease	0.71	disease	4	0.99	deleterious	0.24	neutral	1	deleterious	0.83	deleterious	-2.58	low_impact	0.17	medium_impact	1.94	medium_impact	0.60	0.8	68.72	18.75	0.63	P	0.82	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7641	7641	A	G	MI.5294	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	56	19	E	G	gAg/gGg	9.29	1	0	probably_damaging	0.99	neutral	0.4	neutral	1.54	neutral	-0.37	deleterious	-6.88	low_impact	1.56	0.34	damaging	0.06	damaging	3.94	23.60	deleterious	0.32	0.5	NA	NA	0.67	disease	0.59	disease	0.69	disease	4	0.99	deleterious	0.21	neutral	-2	neutral	0.81	deleterious	-2.58	low_impact	0.11	medium_impact	0.36	medium_impact	0.48	0.8	68.72	18.75	0.62	P	0.64	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7642	7642	G	T	MI.5295	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	57	19	E	D	gaG/gaT	8.59	1	0	probably_damaging	0.94	neutral	0.18	neutral	1.49	neutral	-1.06	deleterious	-2.95	medium_impact	2.21	0.32	damaging	0.05	damaging	3.57	23.10	deleterious	0.4	0.5	NA	NA	0.62	disease	0.39	neutral	0.49	neutral	0	0.96	neutral	0.12	neutral	1	deleterious	0.79	deleterious	-1.83	low_impact	-0.16	medium_impact	0.97	medium_impact	0.70	0.85	68.72	18.75	0.69	P	0.81	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7642	7642	G	C	MI.5296	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	57	19	E	D	gaG/gaC	8.59	1	0	probably_damaging	0.94	neutral	0.18	neutral	1.49	neutral	-1.06	deleterious	-2.95	medium_impact	2.21	0.32	damaging	0.05	damaging	3.41	23.00	deleterious	0.4	0.5	NA	NA	0.62	disease	0.39	neutral	0.49	neutral	0	0.96	neutral	0.12	neutral	1	deleterious	0.79	deleterious	-1.83	low_impact	-0.16	medium_impact	0.97	medium_impact	0.70	0.85	68.72	18.75	0.69	P	0.81	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7643	7643	C	G	MI.5297	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	58	20	L	V	Ctt/Gtt	0.06	0	0	probably_damaging	0.98	neutral	0.25	neutral	1.32	neutral	-1.26	deleterious	-2.91	medium_impact	3	0.24	damaging	0.01	damaging	3.23	22.80	deleterious	0.35	0.5	NA	NA	0.6	disease	0.46	neutral	0.47	neutral	1	0.99	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-2.3	low_impact	-0.06	medium_impact	1.71	medium_impact	0.74	0.85	68.72	18.21	0.69	P	0.66	polymorphism	0.53	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7643	7643	C	A	MI.5298	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	58	20	L	I	Ctt/Att	0.06	0	0	probably_damaging	0.99	neutral	0.25	neutral	1.33	neutral	-1.16	neutral	-1.95	low_impact	1.54	0.31	damaging	0.05	damaging	4.04	23.70	deleterious	0.33	0.5	NA	NA	0.64	disease	0.41	neutral	0.47	neutral	1	1	deleterious	0.13	neutral	-2	neutral	0.79	deleterious	-2.58	low_impact	-0.06	medium_impact	0.34	medium_impact	0.71	0.85	68.72	18.21	0.53	P	0.63	polymorphism	0.67	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7643	7643	C	T	MI.5299	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	58	20	L	F	Ctt/Ttt	0.06	0	0	probably_damaging	1	neutral	0.29	neutral	1.14	deleterious	-3.52	deleterious	-3.9	medium_impact	3.04	0.23	damaging	0.04	damaging	3.77	23.40	deleterious	0.35	0.5	NA	NA	0.7	disease	0.51	disease	0.53	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	-0.01	medium_impact	1.75	medium_impact	0.74	0.85	68.72	18.21	0.71	P	0.91	disease_causing	0.82	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8549	8549	C	T	MI.53	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	23	8	S	L	tCa/tTa	2.9	1	0	benign	0.09	neutral	0.18	neutral	4.65	neutral	-0.84	deleterious	-2.65	low_impact	1.84	0.84	neutral	0.61	neutral	3.59	23.20	deleterious	0.36	0.65	0.68	disease	0.73	disease	0.48	neutral	0.53	disease	1	0.8	neutral	0.55	deleterious	-6	neutral	0.40	neutral	0.2	medium_impact	-0.08	medium_impact	0.48	medium_impact	0.84	0.9	21.24	17.86	0.57	P	0.87	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8774	8774	A	C	MI.530	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	248	83	N	T	aAc/aCc	8.46	1	0	probably_damaging	0.99	deleterious	0	neutral	2.82	deleterious	-6.31	deleterious	-5.49	high_impact	4.65	0.54	damaging	0.4	neutral	3.27	22.80	deleterious	0.34	0.65	0.95	disease	0.81	disease	0.71	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-1.4	low_impact	2.89	high_impact	0.49	0.9	49.12	8.61	0.53	P	0.96	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7644	7644	T	G	MI.5300	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	59	20	L	R	cTt/cGt	-0.4	0	0	probably_damaging	1	neutral	0.09	neutral	1.11	deleterious	-4.85	deleterious	-5.85	high_impact	4.32	0.2	damaging	0.01	damaging	4.03	23.70	deleterious	0.09	0.35	NA	NA	0.89	disease	0.73	disease	0.78	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.35	medium_impact	2.95	high_impact	0.61	0.8	68.72	18.21	0.71	P	0.99	disease_causing	0.97	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7644	7644	T	C	MI.5301	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	59	20	L	P	cTt/cCt	-0.4	0	0	probably_damaging	1	neutral	0.15	neutral	1.1	deleterious	-5.44	deleterious	-6.83	high_impact	3.97	0.16	damaging	0.04	damaging	3.67	23.30	deleterious	0.09	0.35	NA	NA	0.81	disease	0.74	disease	0.74	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.21	medium_impact	2.62	high_impact	0.54	0.8	68.72	18.21	0.72	P	0.99	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7644	7644	T	A	MI.5302	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	59	20	L	H	cTt/cAt	-0.4	0	0	probably_damaging	1	neutral	0.14	neutral	1.1	deleterious	-5.49	deleterious	-6.83	high_impact	4.32	0.26	damaging	0.01	damaging	3.93	23.50	deleterious	0.14	0.4	NA	NA	0.81	disease	0.69	disease	0.69	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.23	medium_impact	2.95	high_impact	0.64	0.8	68.72	18.21	0.61	P	0.94	disease_causing	0.95	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7646	7646	A	G	MI.5303	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	61	21	I	V	Atc/Gtc	-14.47	0	0	benign	0	neutral	0.53	neutral	1.47	neutral	-1	neutral	-0.82	low_impact	1.07	0.85	neutral	0.86	neutral	-0.23	0.95	neutral	0.64	0.7	NA	NA	0.25	neutral	0.27	neutral	0.21	neutral	6	0.47	neutral	0.77	deleterious	-6	neutral	0.10	neutral	2.08	high_impact	0.23	medium_impact	-0.1	medium_impact	0.54	0.8	32.6	58.85	0.37	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7646	7646	A	C	MI.5304	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	61	21	I	L	Atc/Ctc	-14.47	0	0	benign	0.02	neutral	1	neutral	1.52	neutral	-0.53	neutral	0.86	neutral_impact	0.48	0.77	neutral	0.96	neutral	-0.99	0.02	neutral	0.43	0.55	NA	NA	0.27	neutral	0.19	neutral	0.2	neutral	6	0.02	neutral	0.99	deleterious	-6	neutral	0.12	neutral	0.86	medium_impact	1.86	high_impact	-0.66	medium_impact	0.74	0.85	32.6	58.85	0.35	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7646	7646	A	T	MI.5305	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	61	21	I	F	Atc/Ttc	-14.47	0	0	benign	0.24	neutral	0.64	neutral	1.42	neutral	-1.84	neutral	-2.3	medium_impact	2.69	0.54	damaging	0.49	neutral	1.91	15.62	deleterious	0.42	0.55	NA	NA	0.62	disease	0.56	disease	0.68	disease	4	0.25	neutral	0.7	deleterious	-3	neutral	0.38	neutral	-0.25	medium_impact	0.34	medium_impact	1.42	medium_impact	0.72	0.85	32.6	58.85	0.33	N	0.36	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7647	7647	T	C	MI.5306	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	62	21	I	T	aTc/aCc	-0.86	0	0	benign	0.07	neutral	0.35	neutral	1.44	neutral	-1.55	deleterious	-3.12	low_impact	1.44	0.73	neutral	0.73	neutral	0.20	4.73	deleterious	0.49	0.55	NA	NA	0.35	neutral	0.31	neutral	0.2	neutral	6	0.61	neutral	0.64	deleterious	-6	neutral	0.16	neutral	0.33	medium_impact	0.06	medium_impact	0.25	medium_impact	0.59	0.8	32.6	58.85	0.42	N	0.14	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7647	7647	T	G	MI.5307	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	62	21	I	S	aTc/aGc	-0.86	0	0	benign	0.11	neutral	0.51	neutral	1.43	neutral	-1.73	deleterious	-4.06	low_impact	1.14	0.62	neutral	0.53	neutral	2.13	17.02	deleterious	0.36	0.5	NA	NA	0.6	disease	0.33	neutral	0.46	neutral	1	0.41	neutral	0.7	deleterious	-6	neutral	0.23	neutral	0.13	medium_impact	0.21	medium_impact	-0.04	medium_impact	0.56	0.8	32.6	58.85	0.33	N	0.22	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7647	7647	T	A	MI.5308	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	62	21	I	N	aTc/aAc	-0.86	0	0	benign	0.41	neutral	0.27	neutral	1.41	neutral	-2.24	deleterious	-5	low_impact	1.73	0.62	neutral	0.48	neutral	2.49	19.38	deleterious	0.31	0.45	NA	NA	0.61	disease	0.34	neutral	0.46	neutral	1	0.69	neutral	0.43	neutral	-6	neutral	0.46	deleterious	-0.57	medium_impact	-0.03	medium_impact	0.52	medium_impact	0.58	0.8	32.6	58.85	0.39	N	0.46	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7648	7648	C	A	MI.5309	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	63	21	I	M	atC/atA	3.75	0.41	0	possibly_damaging	0.49	neutral	0.4	neutral	1.41	neutral	-2.14	neutral	-0.38	neutral_impact	0.76	0.76	neutral	0.95	neutral	2.02	16.35	deleterious	0.49	0.55	NA	NA	0.25	neutral	0.22	neutral	0.21	neutral	6	0.57	neutral	0.46	neutral	-3	neutral	0.36	neutral	-0.7	medium_impact	0.11	medium_impact	-0.39	medium_impact	0.80	0.85	32.6	58.85	0.4	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8774	8774	A	G	MI.531	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	248	83	N	S	aAc/aGc	8.46	1	0	probably_damaging	0.99	deleterious	0	neutral	2.84	deleterious	-5.83	deleterious	-4.57	high_impact	4.1	0.48	damaging	0.47	neutral	3.03	22.30	deleterious	0.52	0.65	0.93	disease	0.81	disease	0.69	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-1.4	low_impact	2.42	high_impact	0.37	0.9	49.12	8.61	0.53	P	0.91	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7648	7648	C	G	MI.5310	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	63	21	I	M	atC/atG	3.75	0.41	0	possibly_damaging	0.49	neutral	0.4	neutral	1.41	neutral	-2.14	neutral	-0.38	neutral_impact	0.76	0.76	neutral	0.95	neutral	1.57	13.71	neutral	0.49	0.55	NA	NA	0.25	neutral	0.22	neutral	0.21	neutral	6	0.57	neutral	0.46	neutral	-3	neutral	0.36	neutral	-0.7	medium_impact	0.11	medium_impact	-0.39	medium_impact	0.80	0.85	32.6	58.85	0.4	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7649	7649	A	G	MI.5311	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	64	22	T	A	Acc/Gcc	-5.01	0	0	benign	0	neutral	0.5	neutral	1.6	neutral	0	neutral	0	neutral_impact	-0.42	0.91	neutral	0.88	neutral	0.21	4.74	deleterious	0.58	0.65	NA	NA	0.28	neutral	0.34	neutral	0.15	neutral	7	0.5	neutral	0.75	deleterious	-6	neutral	0.12	neutral	2.08	high_impact	0.21	medium_impact	-1.5	low_impact	0.50	0.8	34.36	63.84	0.32	N	0.25	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7649	7649	A	C	MI.5312	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	64	22	T	P	Acc/Ccc	-5.01	0	0	benign	0.14	neutral	0.22	neutral	1.54	neutral	-1.81	neutral	-0.42	low_impact	0.9	0.65	neutral	0.49	neutral	1.55	13.58	neutral	0.12	0.4	NA	NA	0.76	disease	0.58	disease	0.69	disease	4	0.75	neutral	0.54	deleterious	-6	neutral	0.29	neutral	0.01	medium_impact	-0.1	medium_impact	-0.26	medium_impact	0.66	0.8	34.36	63.84	0.34	N	0.32	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7649	7649	A	T	MI.5313	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	64	22	T	S	Acc/Tcc	-5.01	0	0	benign	0	neutral	0.41	neutral	1.6	neutral	0.35	neutral	0.69	neutral_impact	-0.77	0.86	neutral	0.95	neutral	0.00	2.62	deleterious	0.43	0.55	NA	NA	0.3	neutral	0.32	neutral	0.15	neutral	7	0.59	neutral	0.71	deleterious	-6	neutral	0.14	neutral	2.08	high_impact	0.12	medium_impact	-1.83	low_impact	0.75	0.85	34.36	63.84	0.31	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7650	7650	C	A	MI.5314	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	65	22	T	N	aCc/aAc	-0.17	0	0	benign	0.08	neutral	0.3	neutral	1.59	neutral	-0.27	neutral	1.93	neutral_impact	-1	0.75	neutral	0.96	neutral	1.60	13.88	neutral	0.44	0.55	NA	NA	0.5	neutral	0.21	neutral	0.42	neutral	2	0.67	neutral	0.61	deleterious	-6	neutral	0.18	neutral	0.27	medium_impact	0	medium_impact	-2.04	low_impact	0.78	0.85	34.36	63.84	0.41	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7650	7650	C	G	MI.5315	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	65	22	T	S	aCc/aGc	-0.17	0	0	benign	0	neutral	0.41	neutral	1.6	neutral	0.35	neutral	0.69	neutral_impact	-0.77	0.86	neutral	0.95	neutral	0.23	5.02	deleterious	0.43	0.55	NA	NA	0.3	neutral	0.32	neutral	0.15	neutral	7	0.59	neutral	0.71	deleterious	-6	neutral	0.14	neutral	2.08	high_impact	0.12	medium_impact	-1.83	low_impact	0.75	0.85	34.36	63.84	0.31	N	0.13	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7650	7650	C	T	MI.5316	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	65	22	T	I	aCc/aTc	-0.17	0	0	benign	0	neutral	0.44	neutral	1.6	neutral	-1.31	neutral	-0.95	neutral_impact	-0.3	0.83	neutral	0.83	neutral	1.87	15.42	deleterious	0.41	0.5	NA	NA	0.6	disease	0.44	neutral	0.47	neutral	1	0.56	neutral	0.72	deleterious	-6	neutral	0.17	neutral	2.08	high_impact	0.15	medium_impact	-1.39	low_impact	0.70	0.85	34.36	63.84	0.31	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7652	7652	T	G	MI.5317	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	67	23	F	V	Ttt/Gtt	-3.4	0	0	probably_damaging	1	neutral	0.12	neutral	1.18	neutral	-2.63	deleterious	-6.06	high_impact	4.17	0.34	damaging	0.4	neutral	3.89	23.50	deleterious	0.22	0.45	NA	NA	0.89	disease	0.76	disease	0.76	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.27	medium_impact	2.8	high_impact	0.68	0.85	68.28	18.81	0.69	P	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7652	7652	T	C	MI.5318	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	67	23	F	L	Ttt/Ctt	-3.4	0	0	probably_damaging	1	neutral	0.25	neutral	1.68	neutral	0.29	deleterious	-4.87	medium_impact	2	0.38	damaging	0.58	neutral	3.81	23.40	deleterious	0.37	0.5	NA	NA	0.76	disease	0.52	disease	0.47	neutral	1	1	deleterious	0.13	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	-0.06	medium_impact	0.77	medium_impact	0.74	0.85	68.28	18.81	0.57	P	0.81	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7652	7652	T	A	MI.5319	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	67	23	F	I	Ttt/Att	-3.4	0	0	probably_damaging	1	neutral	0.16	neutral	1.29	neutral	-1.46	deleterious	-5.08	high_impact	4.17	0.32	damaging	0.51	neutral	4.22	23.90	deleterious	0.2	0.45	NA	NA	0.88	disease	0.75	disease	0.76	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.19	medium_impact	2.8	high_impact	0.67	0.85	68.28	18.81	0.74	P	0.87	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8775	8775	C	G	MI.532	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	249	83	N	K	aaC/aaG	6.61	1	0	probably_damaging	0.99	deleterious	0	neutral	2.81	deleterious	-7.02	deleterious	-5.52	high_impact	4.65	0.46	damaging	0.32	neutral	3.91	23.50	deleterious	0.42	0.65	0.98	disease	0.88	disease	0.79	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.65	low_impact	-1.4	low_impact	2.89	high_impact	0.58	0.9	49.12	8.61	0.61	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7653	7653	T	A	MI.5320	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	68	23	F	Y	tTt/tAt	7.44	1	0	probably_damaging	1	neutral	0.12	neutral	1.11	deleterious	-4.58	deleterious	-2.75	medium_impact	3.42	0.33	damaging	0.36	neutral	4.03	23.60	deleterious	0.23	0.45	NA	NA	0.8	disease	0.77	disease	0.73	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	-0.27	medium_impact	2.1	high_impact	0.68	0.85	68.28	18.81	0.78	P	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7653	7653	T	C	MI.5321	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	68	23	F	S	tTt/tCt	7.44	1	0	probably_damaging	1	neutral	0.07	neutral	1.1	deleterious	-5.21	deleterious	-7.25	high_impact	4.51	0.34	damaging	0.47	neutral	4.03	23.60	deleterious	0.16	0.45	NA	NA	0.85	disease	0.75	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.42	medium_impact	3.12	high_impact	0.49	0.8	68.28	18.81	0.75	P	0.96	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7653	7653	T	G	MI.5322	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	68	23	F	C	tTt/tGt	7.44	1	0	probably_damaging	1	deleterious	0.01	neutral	1.09	deleterious	-6.04	deleterious	-7.15	high_impact	4.51	0.32	damaging	0.4	neutral	3.96	23.60	deleterious	0.18	0.45	NA	NA	0.84	disease	0.78	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-3.52	low_impact	-0.9	medium_impact	3.12	high_impact	0.46	0.8	68.28	18.81	0.74	P	1.00	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7654	7654	T	A	MI.5323	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	69	23	F	L	ttT/ttA	7.44	1	0	probably_damaging	1	neutral	0.25	neutral	1.68	neutral	0.29	deleterious	-4.87	medium_impact	2	0.38	damaging	0.58	neutral	4.25	23.90	deleterious	0.37	0.5	NA	NA	0.76	disease	0.52	disease	0.47	neutral	1	1	deleterious	0.13	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	-0.06	medium_impact	0.77	medium_impact	0.74	0.85	68.28	18.81	0.76	P	0.81	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7654	7654	T	G	MI.5324	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	69	23	F	L	ttT/ttG	7.44	1	0	probably_damaging	1	neutral	0.25	neutral	1.68	neutral	0.29	deleterious	-4.87	medium_impact	2	0.38	damaging	0.58	neutral	4.17	23.80	deleterious	0.37	0.5	NA	NA	0.76	disease	0.52	disease	0.47	neutral	1	1	deleterious	0.13	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	-0.06	medium_impact	0.77	medium_impact	0.74	0.85	68.28	18.81	0.76	P	0.81	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7655	7655	C	A	MI.5325	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	70	24	H	N	Cat/Aat	-2.94	0	0	probably_damaging	1	neutral	0.16	neutral	1.2	neutral	-2.86	deleterious	-6.89	medium_impact	2.8	0.17	damaging	0.01	damaging	3.74	23.30	deleterious	0.5	0.6	NA	NA	0.79	disease	0.81	disease	0.73	disease	5	1	deleterious	0.08	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	-0.19	medium_impact	1.52	medium_impact	0.47	0.8	67.84	19.12	0.74	P	0.96	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7655	7655	C	T	MI.5326	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	70	24	H	Y	Cat/Tat	-2.94	0	0	probably_damaging	1	neutral	0.51	neutral	1.22	neutral	-2.39	deleterious	-5.88	medium_impact	2.98	0.18	damaging	0.01	damaging	3.41	23.00	deleterious	0.46	0.55	NA	NA	0.84	disease	0.78	disease	0.69	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.87	deleterious	-3.52	low_impact	0.21	medium_impact	1.69	medium_impact	0.26	0.8	67.84	19.12	0.71	P	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7655	7655	C	G	MI.5327	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	70	24	H	D	Cat/Gat	-2.94	0	0	probably_damaging	1	neutral	0.17	neutral	1.2	neutral	-2.74	deleterious	-8.86	medium_impact	3.38	0.21	damaging	0.02	damaging	3.68	23.30	deleterious	0.25	0.45	NA	NA	0.84	disease	0.86	disease	0.77	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	-0.18	medium_impact	2.06	high_impact	0.44	0.8	67.84	19.12	0.67	P	0.97	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7656	7656	A	G	MI.5328	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	71	24	H	R	cAt/cGt	7.21	1	0	probably_damaging	1	neutral	0.14	neutral	1.17	deleterious	-3.44	deleterious	-7.87	high_impact	4.53	0.19	damaging	0.01	damaging	2.64	20.50	deleterious	0.45	0.55	NA	NA	0.89	disease	0.84	disease	0.78	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.23	medium_impact	3.14	high_impact	0.48	0.8	67.84	19.12	0.84	P	0.95	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7656	7656	A	C	MI.5329	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	71	24	H	P	cAt/cCt	7.21	1	0	probably_damaging	1	neutral	0.2	neutral	1.15	deleterious	-4.69	deleterious	-9.84	high_impact	4.18	0.16	damaging	0.04	damaging	3.13	22.60	deleterious	0.26	0.45	NA	NA	0.87	disease	0.87	disease	0.77	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.13	medium_impact	2.81	high_impact	0.28	0.8	67.84	19.12	0.82	P	0.98	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8775	8775	C	A	MI.533	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	249	83	N	K	aaC/aaA	6.61	1	0	probably_damaging	0.99	deleterious	0	neutral	2.81	deleterious	-7.02	deleterious	-5.52	high_impact	4.65	0.46	damaging	0.32	neutral	4.38	24.10	deleterious	0.42	0.65	0.98	disease	0.88	disease	0.79	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-2.65	low_impact	-1.4	low_impact	2.89	high_impact	0.58	0.9	49.12	8.61	0.62	P	1.00	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7656	7656	A	T	MI.5330	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	71	24	H	L	cAt/cTt	7.21	1	0	probably_damaging	1	neutral	0.41	neutral	1.19	deleterious	-3.13	deleterious	-10.81	high_impact	4.53	0.14	damaging	0.01	damaging	1.69	14.35	neutral	0.34	0.5	NA	NA	0.9	disease	0.82	disease	0.77	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.12	medium_impact	3.14	high_impact	0.26	0.8	67.84	19.12	0.79	P	0.91	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7657	7657	T	G	MI.5331	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	72	24	H	Q	caT/caG	6.98	1	0	probably_damaging	1	neutral	0.16	neutral	1.18	deleterious	-3.28	deleterious	-7.87	high_impact	3.98	0.14	damaging	0.02	damaging	3.30	22.90	deleterious	0.47	0.55	NA	NA	0.79	disease	0.81	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.19	medium_impact	2.63	high_impact	0.44	0.8	67.84	19.12	0.86	P	0.94	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7657	7657	T	A	MI.5332	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	72	24	H	Q	caT/caA	6.98	1	0	probably_damaging	1	neutral	0.16	neutral	1.18	deleterious	-3.28	deleterious	-7.87	high_impact	3.98	0.14	damaging	0.02	damaging	3.55	23.10	deleterious	0.47	0.55	NA	NA	0.79	disease	0.81	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.19	medium_impact	2.63	high_impact	0.44	0.8	67.84	19.12	0.86	P	0.94	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7658	7658	G	C	MI.5333	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	73	25	D	H	Gat/Cat	-2.48	0	0	probably_damaging	1	neutral	0.35	neutral	1.09	neutral	-2.92	deleterious	-6.9	medium_impact	2.73	0.12	damaging	0.03	damaging	3.47	23.00	deleterious	0.3	0.45	NA	NA	0.87	disease	0.73	disease	0.74	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	0.06	medium_impact	1.45	medium_impact	0.26	0.8	67.84	18.97	0.71	P	0.98	polymorphism	0.79	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7658	7658	G	A	MI.5334	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	73	25	D	N	Gat/Aat	-2.48	0	0	probably_damaging	1	neutral	0.17	neutral	1.32	neutral	-0.99	deleterious	-4.93	medium_impact	2.32	0.15	damaging	0.02	damaging	4.10	23.70	deleterious	0.62	0.65	NA	NA	0.78	disease	0.62	disease	0.61	disease	2	1	deleterious	0.09	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	-0.18	medium_impact	1.07	medium_impact	0.46	0.8	67.84	18.97	0.79	P	0.99	polymorphism	0.95	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7658	7658	G	T	MI.5335	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	73	25	D	Y	Gat/Tat	-2.48	0	0	probably_damaging	1	neutral	0.56	neutral	1.01	deleterious	-5.94	deleterious	-8.88	high_impact	3.91	0.16	damaging	0.03	damaging	3.74	23.30	deleterious	0.3	0.45	NA	NA	0.93	disease	0.72	disease	0.8	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.26	medium_impact	2.56	high_impact	0.25	0.8	67.84	18.97	0.54	P	0.99	polymorphism	0.65	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7659	7659	A	C	MI.5336	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	74	25	D	A	gAt/gCt	5.13	1	0	probably_damaging	1	neutral	0.26	neutral	1.05	deleterious	-3.73	deleterious	-7.89	high_impact	3.77	0.23	damaging	0.1	damaging	3.57	23.20	deleterious	0.33	0.5	NA	NA	0.82	disease	0.72	disease	0.71	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	-0.05	medium_impact	2.43	high_impact	0.24	0.8	67.84	18.97	0.83	P	0.96	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7659	7659	A	G	MI.5337	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	74	25	D	G	gAt/gGt	5.13	1	0	probably_damaging	1	neutral	0.19	neutral	1.04	deleterious	-4.16	deleterious	-6.9	medium_impact	3.26	0.11	damaging	0.03	damaging	3.93	23.50	deleterious	0.3	0.45	NA	NA	0.89	disease	0.7	disease	0.74	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	-0.14	medium_impact	1.95	medium_impact	0.24	0.8	67.84	18.97	0.85	P	0.97	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7659	7659	A	T	MI.5338	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	74	25	D	V	gAt/gTt	5.13	1	0	probably_damaging	1	neutral	0.3	neutral	1.02	deleterious	-5.21	deleterious	-8.88	high_impact	4.11	0.13	damaging	0.01	damaging	3.64	23.20	deleterious	0.31	0.45	NA	NA	0.93	disease	0.73	disease	0.79	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0	medium_impact	2.75	high_impact	0.20	0.8	67.84	18.97	0.79	P	0.99	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7660	7660	T	A	MI.5339	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	75	25	D	E	gaT/gaA	8.59	1	0	probably_damaging	0.99	neutral	0.17	neutral	1.13	neutral	-2.43	deleterious	-3.94	medium_impact	3.14	0.15	damaging	0.03	damaging	3.92	23.50	deleterious	0.47	0.55	NA	NA	0.84	disease	0.67	disease	0.72	disease	4	0.99	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-2.58	low_impact	-0.18	medium_impact	1.84	medium_impact	0.44	0.8	67.84	18.97	0.91	P	0.95	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8776	8776	C	T	MI.534	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	250	84	L	F	Ctc/Ttc	-4.04	0	0	probably_damaging	1	neutral	0.65	neutral	4.18	neutral	-2.54	deleterious	-3.31	low_impact	1.81	0.94	neutral	0.65	neutral	3.85	23.40	deleterious	0.41	0.65	0.55	disease	0.35	neutral	0.5	neutral	0.58	disease	2	0.99	deleterious	0.33	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.44	medium_impact	0.45	medium_impact	0.50	0.9	42.04	7.65	0.28	N	0.97	polymorphism	0.8	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7660	7660	T	G	MI.5340	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	75	25	D	E	gaT/gaG	8.59	1	0	probably_damaging	0.99	neutral	0.17	neutral	1.13	neutral	-2.43	deleterious	-3.94	medium_impact	3.14	0.15	damaging	0.03	damaging	3.78	23.40	deleterious	0.47	0.55	NA	NA	0.84	disease	0.67	disease	0.72	disease	4	0.99	deleterious	0.09	neutral	1	deleterious	0.86	deleterious	-2.58	low_impact	-0.18	medium_impact	1.84	medium_impact	0.44	0.8	67.84	18.97	0.91	P	0.95	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7661	7661	C	A	MI.5341	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	76	26	H	N	Cac/Aac	-2.94	0	0	benign	0.09	neutral	0.14	neutral	1.53	neutral	-0.56	deleterious	-6.89	medium_impact	2.92	0.31	damaging	0.18	damaging	1.96	15.95	deleterious	0.48	0.55	NA	NA	0.82	disease	0.71	disease	0.72	disease	4	0.85	neutral	0.53	deleterious	-3	neutral	0.33	neutral	0.22	medium_impact	-0.23	medium_impact	1.63	medium_impact	0.46	0.8	69.16	14.91	0.56	P	0.96	disease_causing	0.68	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7661	7661	C	G	MI.5342	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	76	26	H	D	Cac/Gac	-2.94	0	0	benign	0.14	neutral	0.05	neutral	1.47	neutral	-1.4	deleterious	-8.87	medium_impact	2.64	0.33	damaging	0.17	damaging	1.81	15.05	deleterious	0.24	0.45	NA	NA	0.87	disease	0.79	disease	0.75	disease	5	0.94	neutral	0.46	neutral	-3	neutral	0.38	neutral	0.01	medium_impact	-0.5	medium_impact	1.37	medium_impact	0.46	0.8	69.16	14.91	0.58	P	0.97	disease_causing	0.88	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7661	7661	C	T	MI.5343	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	76	26	H	Y	Cac/Tac	-2.94	0	0	benign	0	neutral	0.31	neutral	1.52	neutral	-0.65	deleterious	-5.9	medium_impact	2.16	0.46	damaging	0.16	damaging	1.48	13.22	neutral	0.58	0.65	NA	NA	0.85	disease	0.56	disease	0.43	neutral	1	0.69	neutral	0.66	deleterious	-3	neutral	0.30	neutral	2.08	high_impact	0.01	medium_impact	0.92	medium_impact	0.28	0.8	69.16	14.91	0.34	N	0.99	disease_causing	0.73	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7662	7662	A	C	MI.5344	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	77	26	H	P	cAc/cCc	2.83	0.98	0	benign	0.42	neutral	0.09	neutral	1.43	neutral	-2.92	deleterious	-9.85	high_impact	3.76	0.29	damaging	0.18	damaging	2.63	20.40	deleterious	0.24	0.45	NA	NA	0.9	disease	0.81	disease	0.76	disease	5	0.9	neutral	0.34	neutral	-2	neutral	0.53	deleterious	-0.59	medium_impact	-0.35	medium_impact	2.42	high_impact	0.24	0.8	69.16	14.91	0.77	P	0.98	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7662	7662	A	T	MI.5345	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	77	26	H	L	cAc/cTc	2.83	0.98	0	benign	0.04	neutral	0.26	neutral	1.47	neutral	-1.43	deleterious	-10.83	medium_impact	2.68	0.3	damaging	0.3	neutral	1.69	14.33	neutral	0.34	0.5	NA	NA	0.92	disease	0.72	disease	0.74	disease	5	0.72	neutral	0.61	deleterious	-3	neutral	0.33	neutral	0.57	medium_impact	-0.05	medium_impact	1.41	medium_impact	0.24	0.8	69.16	14.91	0.74	P	0.91	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7662	7662	A	G	MI.5346	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	77	26	H	R	cAc/cGc	2.83	0.98	0	benign	0.06	neutral	0.08	neutral	1.47	neutral	-1.62	deleterious	-7.88	high_impact	3.76	0.28	damaging	0.15	damaging	0.91	10.14	neutral	0.48	0.55	NA	NA	0.91	disease	0.76	disease	0.75	disease	5	0.91	neutral	0.51	deleterious	-2	neutral	0.37	neutral	0.39	medium_impact	-0.38	medium_impact	2.42	high_impact	0.42	0.8	69.16	14.91	0.8	P	0.95	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7663	7663	C	A	MI.5347	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	78	26	H	Q	caC/caA	8.59	1	0	benign	0	neutral	0.2	neutral	1.48	neutral	-1.21	deleterious	-7.87	medium_impact	2.9	0.41	damaging	0.2	damaging	1.75	14.69	neutral	0.52	0.6	NA	NA	0.79	disease	0.69	disease	0.49	neutral	0	0.8	neutral	0.6	deleterious	-3	neutral	0.26	neutral	2.08	high_impact	-0.13	medium_impact	1.61	medium_impact	0.42	0.8	69.16	14.91	0.65	P	0.94	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7663	7663	C	G	MI.5348	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	78	26	H	Q	caC/caG	8.59	1	0	benign	0	neutral	0.2	neutral	1.48	neutral	-1.21	deleterious	-7.87	medium_impact	2.9	0.41	damaging	0.2	damaging	1.41	12.83	neutral	0.52	0.6	NA	NA	0.79	disease	0.69	disease	0.49	neutral	0	0.8	neutral	0.6	deleterious	-3	neutral	0.26	neutral	2.08	high_impact	-0.13	medium_impact	1.61	medium_impact	0.42	0.8	69.16	14.91	0.65	P	0.94	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7664	7664	G	T	MI.5349	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	79	27	A	S	Gcc/Tcc	-2.48	0	0.02	benign	0.34	neutral	0.53	neutral	1.47	neutral	-1.25	neutral	-1.41	low_impact	1.37	0.54	damaging	0.59	neutral	0.78	9.36	deleterious	0.48	0.55	NA	NA	0.47	neutral	0.38	neutral	0.27	neutral	5	0.39	neutral	0.6	deleterious	-6	neutral	0.34	neutral	-0.45	medium_impact	0.23	medium_impact	0.18	medium_impact	0.71	0.85	28.63	44.66	0.36	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8776	8776	C	A	MI.535	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	250	84	L	I	Ctc/Atc	-4.04	0	0	probably_damaging	0.99	neutral	0.17	neutral	4.17	neutral	-2.06	neutral	-1.55	low_impact	1.56	0.94	neutral	0.9	neutral	3.00	22.20	deleterious	0.42	0.65	0.43	neutral	0.37	neutral	0.41	neutral	0.46	neutral	1	0.99	deleterious	0.09	neutral	-2	neutral	0.71	deleterious	-2.65	low_impact	-0.1	medium_impact	0.24	medium_impact	0.65	0.9	42.04	7.65	0.45	N	0.87	polymorphism	0.97	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7664	7664	G	C	MI.5350	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	79	27	A	P	Gcc/Ccc	-2.48	0	0.02	possibly_damaging	0.74	neutral	0.3	neutral	1.42	neutral	-2.96	deleterious	-3.37	medium_impact	3.23	0.42	damaging	0.32	neutral	3.54	23.10	deleterious	0.13	0.4	NA	NA	0.89	disease	0.72	disease	0.77	disease	5	0.79	neutral	0.28	neutral	0	NA	0.79	deleterious	-1.14	low_impact	0	medium_impact	1.92	medium_impact	0.71	0.85	28.63	44.66	0.44	N	0.69	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7664	7664	G	A	MI.5351	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	79	27	A	T	Gcc/Acc	-2.48	0	0.02	benign	0.02	neutral	0.66	neutral	1.57	neutral	-0.53	neutral	-0.56	neutral_impact	-0.05	0.79	neutral	0.95	neutral	0.01	2.69	deleterious	0.48	0.55	NA	NA	0.12	neutral	0.28	neutral	0.21	neutral	6	0.3	neutral	0.82	deleterious	-6	neutral	0.12	neutral	0.86	medium_impact	0.36	medium_impact	-1.15	low_impact	0.61	0.8	28.63	44.66	0.3	N	0.01	polymorphism	1	0.03	rs879139393	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7665	7665	C	A	MI.5352	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	80	27	A	D	gCc/gAc	0.29	0	0	possibly_damaging	0.67	neutral	0.3	neutral	1.42	deleterious	-3.39	deleterious	-3.97	high_impact	3.58	0.47	damaging	0.33	neutral	4.17	23.80	deleterious	0.22	0.45	NA	NA	0.87	disease	0.71	disease	0.77	disease	5	0.75	neutral	0.32	neutral	1	deleterious	0.72	deleterious	-1.01	low_impact	0	medium_impact	2.25	high_impact	0.68	0.85	28.63	44.66	0.4	N	0.74	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7665	7665	C	G	MI.5353	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	80	27	A	G	gCc/gGc	0.29	0	0	possibly_damaging	0.54	neutral	0.41	neutral	1.43	neutral	-2.07	deleterious	-3.16	medium_impact	2.68	0.49	damaging	0.57	neutral	3.35	22.90	deleterious	0.28	0.45	NA	NA	0.73	disease	0.57	disease	0.69	disease	4	0.59	neutral	0.44	neutral	0	NA	0.50	deleterious	-0.79	medium_impact	0.12	medium_impact	1.41	medium_impact	0.63	0.8	28.63	44.66	0.39	N	0.59	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7665	7665	C	T	MI.5354	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	80	27	A	V	gCc/gTc	0.29	0	0	benign	0.02	neutral	0.65	neutral	1.62	neutral	0.26	neutral	-2.25	low_impact	1.64	0.63	neutral	0.56	neutral	1.30	12.29	neutral	0.31	0.45	NA	NA	0.72	disease	0.4	neutral	0.49	neutral	0	0.31	neutral	0.82	deleterious	-6	neutral	0.23	neutral	0.86	medium_impact	0.35	medium_impact	0.43	medium_impact	0.68	0.85	28.63	44.66	0.27	N	0.44	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7667	7667	C	G	MI.5355	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	82	28	L	V	Ctc/Gtc	-11.7	0	0	benign	0.26	neutral	0.23	neutral	1.21	neutral	-2.12	deleterious	-2.62	medium_impact	3.19	0.33	damaging	0.32	neutral	1.38	12.68	neutral	0.41	0.5	NA	NA	0.69	disease	0.57	disease	0.64	disease	3	0.72	neutral	0.49	deleterious	-3	neutral	0.32	neutral	-0.3	medium_impact	-0.09	medium_impact	1.89	medium_impact	0.70	0.85	25.99	26.93	0.5	N	0.55	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7667	7667	C	T	MI.5356	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	82	28	L	F	Ctc/Ttc	-11.7	0	0	benign	0.04	neutral	0.37	neutral	1.15	neutral	-2.93	deleterious	-3.46	medium_impact	2.46	0.51	damaging	0.37	neutral	1.81	15.03	deleterious	0.4	0.5	NA	NA	0.74	disease	0.58	disease	0.61	disease	2	0.6	neutral	0.67	deleterious	-3	neutral	0.26	neutral	0.57	medium_impact	0.08	medium_impact	1.2	medium_impact	0.65	0.8	25.99	26.93	0.36	N	0.34	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7667	7667	C	A	MI.5357	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	82	28	L	I	Ctc/Atc	-11.7	0	0	possibly_damaging	0.49	neutral	0.24	neutral	1.19	neutral	-2.32	neutral	-1.76	medium_impact	2.52	0.36	damaging	0.46	neutral	2.14	17.09	deleterious	0.41	0.5	NA	NA	0.72	disease	0.55	disease	0.57	disease	1	0.73	neutral	0.38	neutral	0	NA	0.36	neutral	-0.7	medium_impact	-0.07	medium_impact	1.26	medium_impact	0.68	0.85	25.99	26.93	0.53	P	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7668	7668	T	C	MI.5358	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	83	28	L	P	cTc/cCc	-1.32	0	0	probably_damaging	0.98	neutral	0.06	neutral	1.09	deleterious	-5.6	deleterious	-6.47	high_impact	4	0.27	damaging	0.3	neutral	3.66	23.20	deleterious	0.16	0.45	NA	NA	0.89	disease	0.75	disease	0.77	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.89	deleterious	-2.3	low_impact	-0.46	medium_impact	2.65	high_impact	0.57	0.8	25.99	26.93	0.82	P	0.90	polymorphism	0.97	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7668	7668	T	A	MI.5359	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	83	28	L	H	cTc/cAc	-1.32	0	0	probably_damaging	0.97	neutral	0.28	neutral	1.09	deleterious	-5.66	deleterious	-6.41	high_impact	4	0.39	damaging	0.29	neutral	3.84	23.40	deleterious	0.17	0.45	NA	NA	0.84	disease	0.73	disease	0.74	disease	5	0.98	neutral	0.16	neutral	2	deleterious	0.84	deleterious	-2.13	low_impact	-0.02	medium_impact	2.65	high_impact	0.65	0.8	25.99	26.93	0.46	N	0.84	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8776	8776	C	G	MI.536	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	250	84	L	V	Ctc/Gtc	-4.04	0	0	probably_damaging	0.99	neutral	0.2	neutral	4.23	neutral	-2.07	neutral	-2.32	low_impact	1.79	0.84	neutral	0.63	neutral	2.21	17.57	deleterious	0.45	0.65	0.67	disease	0.39	neutral	0.45	neutral	0.62	disease	2	0.99	deleterious	0.11	neutral	-2	neutral	0.74	deleterious	-2.65	low_impact	-0.05	medium_impact	0.44	medium_impact	0.47	0.9	42.04	7.65	0.34	N	0.87	polymorphism	0.95	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7668	7668	T	G	MI.5360	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	83	28	L	R	cTc/cGc	-1.32	0	0	probably_damaging	0.94	neutral	0.17	neutral	1.09	deleterious	-5.05	deleterious	-5.52	high_impact	4	0.28	damaging	0.26	damaging	3.72	23.30	deleterious	0.18	0.45	NA	NA	0.93	disease	0.75	disease	0.82	disease	6	0.97	neutral	0.12	neutral	2	deleterious	0.88	deleterious	-1.83	low_impact	-0.18	medium_impact	2.65	high_impact	0.66	0.8	25.99	26.93	0.79	P	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7670	7670	A	T	MI.5361	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	85	29	M	L	Ata/Tta	-0.86	0.01	0	possibly_damaging	0.84	neutral	0.61	neutral	1.57	neutral	0.6	neutral	-2.44	low_impact	1.53	0.36	damaging	0.05	damaging	2.06	16.61	deleterious	0.32	0.5	NA	NA	0.57	disease	0.41	neutral	0.44	neutral	1	0.81	neutral	0.39	neutral	-3	neutral	0.59	deleterious	-1.39	low_impact	0.31	medium_impact	0.33	medium_impact	0.29	0.8	68.72	18.95	0.5	N	0.70	polymorphism	1	0.09	rs879117428	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7670	7670	A	G	MI.5362	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	85	29	M	V	Ata/Gta	-0.86	0.01	0	possibly_damaging	0.89	neutral	0.53	neutral	1.53	neutral	0.47	deleterious	-3.25	medium_impact	2.06	0.18	damaging	0.07	damaging	2.52	19.62	deleterious	0.42	0.55	NA	NA	0.8	disease	0.49	neutral	0.49	neutral	0	0.88	neutral	0.32	neutral	0	NA	0.75	deleterious	-1.57	low_impact	0.23	medium_impact	0.83	medium_impact	0.30	0.8	68.72	18.95	0.75	P	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7670	7670	A	C	MI.5363	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	85	29	M	L	Ata/Cta	-0.86	0.01	0	possibly_damaging	0.84	neutral	0.61	neutral	1.57	neutral	0.6	neutral	-2.44	low_impact	1.53	0.36	damaging	0.05	damaging	1.96	15.95	deleterious	0.32	0.5	NA	NA	0.57	disease	0.41	neutral	0.44	neutral	1	0.81	neutral	0.39	neutral	-3	neutral	0.59	deleterious	-1.39	low_impact	0.31	medium_impact	0.33	medium_impact	0.29	0.8	68.72	18.95	0.49	N	0.70	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7671	7671	T	C	MI.5364	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	86	29	M	T	aTa/aCa	8.59	1	0	probably_damaging	0.98	neutral	0.22	neutral	1.52	neutral	-0.82	deleterious	-5.13	medium_impact	2.37	0.18	damaging	0.09	damaging	2.75	21.10	deleterious	0.3	0.45	NA	NA	0.75	disease	0.51	disease	0.48	neutral	0	0.98	deleterious	0.12	neutral	1	deleterious	0.81	deleterious	-2.3	low_impact	-0.1	medium_impact	1.12	medium_impact	0.30	0.8	68.72	18.95	0.85	P	0.92	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7671	7671	T	A	MI.5365	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	86	29	M	K	aTa/aAa	8.59	1	0	probably_damaging	0.95	neutral	0.11	neutral	1.43	neutral	-2.46	deleterious	-5.5	high_impact	3.98	0.07	damaging	0.01	damaging	3.79	23.40	deleterious	0.19	0.45	NA	NA	0.93	disease	0.72	disease	0.8	disease	6	0.98	deleterious	0.08	neutral	2	deleterious	0.86	deleterious	-1.91	low_impact	-0.3	medium_impact	2.63	high_impact	0.38	0.8	68.72	18.95	0.9	P	1.00	disease_causing_automatic	1	0.35	rs199474827	Pathogenic	Hepatic_failure,_early-onset,_and_neurologic_disorder_due_to_cytochrome_C_oxidase_deficiency	24699	MedGen:C0268237,OMIM:220110,Orphanet:ORPHA254905,SNOMED_CT:67434000	.	.	.	.	T7671A	MM	-	+	Reported	2	P	P	P	damaging
chrM	7672	7672	A	T	MI.5366	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	87	29	M	I	atA/atT	4.67	1	0	probably_damaging	0.92	neutral	0.5	neutral	1.53	neutral	0.22	deleterious	-3.23	low_impact	1.54	0.34	damaging	0.15	damaging	2.20	17.49	deleterious	0.37	0.5	NA	NA	0.83	disease	0.47	neutral	0.49	neutral	0	0.92	neutral	0.29	neutral	-2	neutral	0.77	deleterious	-1.71	low_impact	0.21	medium_impact	0.34	medium_impact	0.37	0.8	68.72	18.95	0.68	P	0.78	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7672	7672	A	C	MI.5367	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	87	29	M	I	atA/atC	4.67	1	0	probably_damaging	0.92	neutral	0.5	neutral	1.53	neutral	0.22	deleterious	-3.23	low_impact	1.54	0.34	damaging	0.15	damaging	2.14	17.13	deleterious	0.37	0.5	NA	NA	0.83	disease	0.47	neutral	0.49	neutral	0	0.92	neutral	0.29	neutral	-2	neutral	0.77	deleterious	-1.71	low_impact	0.21	medium_impact	0.34	medium_impact	0.37	0.8	68.72	18.95	0.67	P	0.78	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7673	7673	A	C	MI.5368	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	88	30	I	L	Atc/Ctc	2.14	1	0.01	benign	0.11	neutral	0.51	neutral	1.36	neutral	-1.28	neutral	-1.67	medium_impact	2.31	0.57	damaging	0.36	neutral	1.81	15.06	deleterious	0.32	0.5	NA	NA	0.7	disease	0.51	disease	0.48	neutral	0	0.41	neutral	0.7	deleterious	-3	neutral	0.26	neutral	0.13	medium_impact	0.21	medium_impact	1.06	medium_impact	0.50	0.8	62.11	14.6	0.44	N	0.61	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7673	7673	A	T	MI.5369	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	88	30	I	F	Atc/Ttc	2.14	1	0.01	possibly_damaging	0.69	neutral	0.11	neutral	1.25	neutral	-2.62	deleterious	-3.5	medium_impact	2.15	0.5	damaging	0.3	neutral	3.30	22.90	deleterious	0.31	0.45	NA	NA	0.82	disease	0.58	disease	0.65	disease	3	0.91	neutral	0.21	neutral	0	NA	0.70	deleterious	-1.04	low_impact	-0.3	medium_impact	0.91	medium_impact	0.63	0.8	62.11	14.6	0.51	P	0.86	polymorphism	0.9	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8777	8777	T	A	MI.537	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	251	84	L	H	cTc/cAc	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	4.07	deleterious	-5.48	deleterious	-5.93	high_impact	4.07	0.79	neutral	0.41	neutral	4.06	23.70	deleterious	0.2	0.65	0.93	disease	0.75	disease	0.74	disease	0.8	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.39	high_impact	0.57	0.9	42.04	7.65	0.34	N	0.97	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7673	7673	A	G	MI.5370	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	88	30	I	V	Atc/Gtc	2.14	1	0.01	benign	0.04	neutral	0.44	neutral	1.36	neutral	-1.31	neutral	-0.19	low_impact	1.19	0.88	neutral	0.9	neutral	-0.59	0.13	neutral	0.42	0.5	NA	NA	0.29	neutral	0.4	neutral	0.16	neutral	7	0.52	neutral	0.7	deleterious	-6	neutral	0.18	neutral	0.57	medium_impact	0.15	medium_impact	0.01	medium_impact	0.37	0.8	62.11	14.6	0.5	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7674	7674	T	G	MI.5371	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	89	30	I	S	aTc/aGc	3.52	1	0	benign	0.4	neutral	0.3	neutral	1.24	deleterious	-3.05	deleterious	-4.47	high_impact	3.84	0.55	damaging	0.35	neutral	2.50	19.44	deleterious	0.23	0.45	NA	NA	0.82	disease	0.64	disease	0.66	disease	3	0.65	neutral	0.45	neutral	-2	neutral	0.55	deleterious	-0.56	medium_impact	0	medium_impact	2.5	high_impact	0.54	0.8	62.11	14.6	0.47	N	0.86	polymorphism	0.96	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7674	7674	T	C	MI.5372	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	89	30	I	T	aTc/aCc	3.52	1	0	benign	0.03	neutral	0.16	neutral	1.26	neutral	-2.47	deleterious	-3.52	medium_impact	3.21	0.7	neutral	0.42	neutral	1.35	12.53	neutral	0.35	0.5	NA	NA	0.68	disease	0.56	disease	0.54	disease	1	0.83	neutral	0.57	deleterious	-3	neutral	0.24	neutral	0.69	medium_impact	-0.19	medium_impact	1.9	medium_impact	0.60	0.8	62.11	14.6	0.54	P	0.93	polymorphism	0.99	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7674	7674	T	A	MI.5373	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	89	30	I	N	aTc/aAc	3.52	1	0	possibly_damaging	0.65	neutral	0.08	neutral	1.21	deleterious	-4.2	deleterious	-5.75	high_impact	3.63	0.55	damaging	0.28	neutral	4.10	23.70	deleterious	0.2	0.45	NA	NA	0.81	disease	0.64	disease	0.66	disease	3	0.93	neutral	0.22	neutral	1	deleterious	0.68	deleterious	-0.97	medium_impact	-0.38	medium_impact	2.3	high_impact	0.60	0.8	62.11	14.6	0.47	N	0.99	polymorphism	0.97	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7675	7675	C	A	MI.5374	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	90	30	I	M	atC/atA	4.67	1	0	possibly_damaging	0.83	neutral	0.29	neutral	1.23	deleterious	-3.12	neutral	-2.26	medium_impact	2.83	0.6	neutral	0.35	neutral	3.55	23.10	deleterious	0.33	0.5	NA	NA	0.6	disease	0.43	neutral	0.38	neutral	3	0.86	neutral	0.23	neutral	0	NA	0.67	deleterious	-1.36	low_impact	-0.01	medium_impact	1.55	medium_impact	0.67	0.85	62.11	14.6	0.53	P	0.76	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7675	7675	C	G	MI.5375	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	90	30	I	M	atC/atG	4.67	1	0	possibly_damaging	0.83	neutral	0.29	neutral	1.23	deleterious	-3.12	neutral	-2.26	medium_impact	2.83	0.6	neutral	0.35	neutral	3.05	22.40	deleterious	0.33	0.5	NA	NA	0.6	disease	0.43	neutral	0.38	neutral	3	0.86	neutral	0.23	neutral	0	NA	0.67	deleterious	-1.36	low_impact	-0.01	medium_impact	1.55	medium_impact	0.67	0.85	62.11	14.6	0.53	P	0.76	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7676	7676	A	C	MI.5376	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	91	31	I	L	Att/Ctt	-7.78	0	0	benign	0.03	neutral	1	neutral	1.99	neutral	1.53	neutral	-1.37	neutral_impact	0.73	0.71	neutral	0.68	neutral	-0.06	2.04	deleterious	0.32	0.5	NA	NA	0.13	neutral	0.24	neutral	0.2	neutral	6	0.03	neutral	0.99	deleterious	-6	neutral	0.12	neutral	0.69	medium_impact	1.86	high_impact	-0.42	medium_impact	0.50	0.8	33.04	38.83	0.33	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7676	7676	A	T	MI.5377	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	91	31	I	F	Att/Ttt	-7.78	0	0	benign	0.42	neutral	0.44	neutral	1.36	neutral	-2.84	deleterious	-3.33	medium_impact	3.25	0.59	damaging	0.5	neutral	1.92	15.69	deleterious	0.3	0.45	NA	NA	0.71	disease	0.63	disease	0.71	disease	4	0.51	neutral	0.51	deleterious	-3	neutral	0.48	deleterious	-0.59	medium_impact	0.15	medium_impact	1.94	medium_impact	0.59	0.8	33.04	38.83	0.33	N	0.70	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7676	7676	A	G	MI.5378	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	91	31	I	V	Att/Gtt	-7.78	0	0	benign	0.01	neutral	0.61	neutral	1.53	neutral	-0.33	neutral	0.65	neutral_impact	0.52	0.85	neutral	0.98	neutral	-1.75	0.00	neutral	0.41	0.5	NA	NA	0.14	neutral	0.35	neutral	0.22	neutral	6	0.38	neutral	0.8	deleterious	-6	neutral	0.13	neutral	1.14	medium_impact	0.31	medium_impact	-0.62	medium_impact	0.44	0.8	33.04	38.83	0.33	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7677	7677	T	G	MI.5379	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	92	31	I	S	aTt/aGt	4.21	1	0	possibly_damaging	0.45	neutral	0.16	neutral	1.34	deleterious	-3.38	deleterious	-3.96	medium_impact	2.8	0.62	neutral	0.51	neutral	3.61	23.20	deleterious	0.23	0.45	NA	NA	0.67	disease	0.6	disease	0.69	disease	4	0.82	neutral	0.36	neutral	0	NA	0.48	deleterious	-0.64	medium_impact	-0.19	medium_impact	1.52	medium_impact	0.51	0.8	33.04	38.83	0.5	N	0.70	polymorphism	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8777	8777	T	G	MI.538	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	251	84	L	R	cTc/cGc	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	4.08	deleterious	-4.95	deleterious	-5.04	high_impact	4.07	0.79	neutral	0.38	neutral	4.12	23.80	deleterious	0.18	0.65	0.91	disease	0.86	disease	0.77	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.39	high_impact	0.58	0.9	42.04	7.65	0.39	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7677	7677	T	C	MI.5380	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	92	31	I	T	aTt/aCt	4.21	1	0	benign	0.3	neutral	0.35	neutral	1.36	neutral	-2.81	deleterious	-2.58	medium_impact	2.45	0.76	neutral	0.53	neutral	1.29	12.22	neutral	0.28	0.45	NA	NA	0.44	neutral	0.6	disease	0.4	neutral	2	0.58	neutral	0.53	deleterious	-3	neutral	0.38	neutral	-0.38	medium_impact	0.06	medium_impact	1.19	medium_impact	0.62	0.8	33.04	38.83	0.53	N	0.55	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7677	7677	T	A	MI.5381	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	92	31	I	N	aTt/aAt	4.21	1	0	possibly_damaging	0.81	neutral	0.07	neutral	1.33	deleterious	-4.49	deleterious	-5.2	medium_impact	2.91	0.59	damaging	0.48	neutral	4.00	23.60	deleterious	0.18	0.45	NA	NA	0.75	disease	0.62	disease	0.7	disease	4	0.96	neutral	0.13	neutral	0	NA	0.69	deleterious	-1.31	low_impact	-0.42	medium_impact	1.62	medium_impact	0.58	0.8	33.04	38.83	0.48	N	0.87	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7678	7678	T	G	MI.5382	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	93	31	I	M	atT/atG	5.83	1	0	benign	0.06	neutral	0.27	neutral	1.36	neutral	-2.61	neutral	-1.46	low_impact	1.25	0.85	neutral	0.64	neutral	1.26	12.07	neutral	0.32	0.5	NA	NA	0.38	neutral	0.37	neutral	0.15	neutral	7	0.7	neutral	0.61	deleterious	-6	neutral	0.17	neutral	0.39	medium_impact	-0.03	medium_impact	0.07	medium_impact	0.63	0.8	33.04	38.83	0.58	P	0.03	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7678	7678	T	A	MI.5383	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	93	31	I	M	atT/atA	5.83	1	0	benign	0.06	neutral	0.27	neutral	1.36	neutral	-2.61	neutral	-1.46	low_impact	1.25	0.85	neutral	0.64	neutral	1.60	13.86	neutral	0.32	0.5	NA	NA	0.38	neutral	0.37	neutral	0.15	neutral	7	0.7	neutral	0.61	deleterious	-6	neutral	0.17	neutral	0.39	medium_impact	-0.03	medium_impact	0.07	medium_impact	0.63	0.8	33.04	38.83	0.58	P	0.03	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7679	7679	T	G	MI.5384	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	94	32	F	V	Ttc/Gtc	-13.31	0	0	benign	0.02	neutral	0.65	neutral	1.64	neutral	-0.28	deleterious	-4.32	neutral_impact	0.5	0.63	neutral	0.55	neutral	0.70	8.81	deleterious	0.25	0.45	NA	NA	0.47	neutral	0.38	neutral	0.26	neutral	5	0.31	neutral	0.82	deleterious	-6	neutral	0.15	neutral	0.86	medium_impact	0.35	medium_impact	-0.64	medium_impact	0.61	0.8	26.43	36.86	0.36	N	0.85	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7679	7679	T	C	MI.5385	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	94	32	F	L	Ttc/Ctc	-13.31	0	0	benign	0.01	neutral	1	neutral	1.67	neutral	-0.66	deleterious	-3.31	neutral_impact	0.21	0.77	neutral	0.81	neutral	0.45	7.04	deleterious	0.38	0.5	NA	NA	0.4	neutral	0.37	neutral	0.14	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.13	neutral	1.14	medium_impact	1.86	high_impact	-0.91	medium_impact	0.41	0.8	26.43	36.86	0.27	N	0.89	polymorphism	1	0.10	rs879003775	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7679	7679	T	A	MI.5386	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	94	32	F	I	Ttc/Atc	-13.31	0	0	benign	0.02	neutral	0.65	neutral	1.69	neutral	-0.29	deleterious	-3.48	neutral_impact	-0.7	0.7	neutral	0.72	neutral	0.88	9.95	deleterious	0.25	0.45	NA	NA	0.32	neutral	0.32	neutral	0.14	neutral	7	0.31	neutral	0.82	deleterious	-6	neutral	0.14	neutral	0.86	medium_impact	0.35	medium_impact	-1.76	low_impact	0.51	0.8	26.43	36.86	0.33	N	0.83	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7680	7680	T	G	MI.5387	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	95	32	F	C	tTc/tGc	4.67	1	0	benign	0	neutral	0.05	neutral	1.5	neutral	-2.77	deleterious	-5.75	low_impact	1.72	0.63	neutral	0.37	neutral	1.89	15.55	deleterious	0.2	0.45	NA	NA	0.74	disease	0.54	disease	0.68	disease	4	0.95	neutral	0.53	deleterious	-6	neutral	0.18	neutral	2.08	high_impact	-0.5	medium_impact	0.51	medium_impact	0.35	0.8	26.43	36.86	0.48	N	0.94	polymorphism	0.52	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7680	7680	T	C	MI.5388	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	95	32	F	S	tTc/tCc	4.67	1	0	benign	0	neutral	0.07	neutral	1.53	neutral	-2.13	deleterious	-5.91	low_impact	1.29	0.8	neutral	0.49	neutral	2.01	16.29	deleterious	0.28	0.45	NA	NA	0.57	disease	0.51	disease	0.48	neutral	0	0.93	neutral	0.54	deleterious	-6	neutral	0.18	neutral	2.08	high_impact	-0.42	medium_impact	0.1	medium_impact	0.55	0.8	26.43	36.86	0.5	N	0.42	polymorphism	0.62	0.12	rs386829012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7680	7680	T	A	MI.5389	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	95	32	F	Y	tTc/tAc	4.67	1	0	benign	0.06	neutral	0.06	neutral	1.5	neutral	-2.61	neutral	-2.3	low_impact	1.57	0.72	neutral	0.91	neutral	1.07	11.03	neutral	0.27	0.45	NA	NA	0.56	disease	0.42	neutral	0.45	neutral	1	0.94	neutral	0.5	deleterious	-6	neutral	0.21	neutral	0.39	medium_impact	-0.46	medium_impact	0.37	medium_impact	0.56	0.8	26.43	36.86	0.56	P	0.74	polymorphism	0.93	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8777	8777	T	C	MI.539	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	251	84	L	P	cTc/cCc	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	4.09	deleterious	-5.29	deleterious	-5.95	high_impact	3.52	0.84	neutral	0.41	neutral	3.83	23.40	deleterious	0.17	0.65	0.56	disease	0.84	disease	0.77	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	1.92	medium_impact	0.56	0.9	42.04	7.65	0.4	N	1.00	disease_causing	0.99	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7681	7681	C	G	MI.5390	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	96	32	F	L	ttC/ttG	3.75	1	0.01	benign	0.01	neutral	1	neutral	1.67	neutral	-0.66	deleterious	-3.31	neutral_impact	0.21	0.77	neutral	0.81	neutral	0.77	9.27	deleterious	0.38	0.5	NA	NA	0.4	neutral	0.37	neutral	0.14	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.13	neutral	1.14	medium_impact	1.86	high_impact	-0.91	medium_impact	0.41	0.8	26.43	36.86	0.36	N	0.89	disease_causing	0.68	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7681	7681	C	A	MI.5391	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	96	32	F	L	ttC/ttA	3.75	1	0.01	benign	0.01	neutral	1	neutral	1.67	neutral	-0.66	deleterious	-3.31	neutral_impact	0.21	0.77	neutral	0.81	neutral	1.10	11.21	neutral	0.38	0.5	NA	NA	0.4	neutral	0.37	neutral	0.14	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.13	neutral	1.14	medium_impact	1.86	high_impact	-0.91	medium_impact	0.41	0.8	26.43	36.86	0.36	N	0.89	disease_causing	0.68	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7682	7682	C	T	MI.5392	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	97	33	L	F	Ctt/Ttt	-1.78	0	0	possibly_damaging	0.57	neutral	0.64	neutral	1.4	neutral	-1.89	deleterious	-3.57	medium_impact	1.94	0.52	damaging	0.43	neutral	2.43	19.01	deleterious	0.28	0.45	NA	NA	0.73	disease	0.41	neutral	0.39	neutral	2	0.49	neutral	0.54	deleterious	0	NA	0.71	deleterious	-0.84	medium_impact	0.34	medium_impact	0.71	medium_impact	0.57	0.8	66.52	17.02	0.31	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7682	7682	C	G	MI.5393	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	97	33	L	V	Ctt/Gtt	-1.78	0	0	benign	0.14	neutral	0.26	neutral	1.46	neutral	0.1	neutral	-2.44	medium_impact	2.02	0.55	damaging	0.39	neutral	1.45	13.04	neutral	0.26	0.45	NA	NA	0.62	disease	0.38	neutral	0.23	neutral	5	0.7	neutral	0.56	deleterious	-3	neutral	0.28	neutral	0.01	medium_impact	-0.05	medium_impact	0.79	medium_impact	0.59	0.8	66.52	17.02	0.42	N	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7682	7682	C	A	MI.5394	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	97	33	L	I	Ctt/Att	-1.78	0	0	benign	0.32	neutral	0.45	neutral	1.49	neutral	-0.24	neutral	-1.64	low_impact	1.28	0.59	damaging	0.53	neutral	1.19	11.67	neutral	0.32	0.5	NA	NA	0.47	neutral	0.33	neutral	0.19	neutral	6	0.46	neutral	0.57	deleterious	-6	neutral	0.29	neutral	-0.42	medium_impact	0.16	medium_impact	0.1	medium_impact	0.55	0.8	66.52	17.02	0.34	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7683	7683	T	G	MI.5395	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	98	33	L	R	cTt/cGt	-1.32	0	0	possibly_damaging	0.85	neutral	0.16	neutral	1.34	deleterious	-3.41	deleterious	-5.3	high_impact	3.87	0.44	damaging	0.27	damaging	3.88	23.50	deleterious	0.12	0.4	NA	NA	0.93	disease	0.7	disease	0.77	disease	5	0.92	neutral	0.16	neutral	1	deleterious	0.85	deleterious	-1.42	low_impact	-0.19	medium_impact	2.52	high_impact	0.56	0.8	66.52	17.02	0.45	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7683	7683	T	C	MI.5396	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	98	33	L	P	cTt/cCt	-1.32	0	0	probably_damaging	0.96	neutral	0.09	neutral	1.33	neutral	-2.99	deleterious	-6.16	medium_impact	2.77	0.57	damaging	0.27	damaging	3.63	23.20	deleterious	0.1	0.4	NA	NA	0.9	disease	0.69	disease	0.76	disease	5	0.99	deleterious	0.07	neutral	1	deleterious	0.88	deleterious	-2.01	low_impact	-0.35	medium_impact	1.49	medium_impact	0.61	0.8	66.52	17.02	0.27	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7683	7683	T	A	MI.5397	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	98	33	L	H	cTt/cAt	-1.32	0	0	probably_damaging	0.94	neutral	0.3	neutral	1.33	deleterious	-3.95	deleterious	-6.24	high_impact	3.87	0.53	damaging	0.3	neutral	3.89	23.50	deleterious	0.13	0.4	NA	NA	0.8	disease	0.66	disease	0.73	disease	5	0.95	neutral	0.18	neutral	2	deleterious	0.82	deleterious	-1.83	low_impact	0	medium_impact	2.52	high_impact	0.57	0.8	66.52	17.02	0.35	N	0.94	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7685	7685	A	C	MI.5398	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	100	34	I	L	Atc/Ctc	-2.01	0	0	benign	0.2	neutral	0.24	neutral	0.69	deleterious	-3.24	neutral	-1.98	high_impact	3.79	0.31	damaging	0.33	neutral	1.86	15.34	deleterious	0.31	0.45	NA	NA	0.79	disease	0.67	disease	0.67	disease	3	0.72	neutral	0.52	deleterious	-2	neutral	0.31	neutral	-0.16	medium_impact	-0.07	medium_impact	2.45	high_impact	0.41	0.8	68.72	18.96	0.58	P	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7685	7685	A	G	MI.5399	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	100	34	I	V	Atc/Gtc	-2.01	0	0	benign	0.01	neutral	0.15	neutral	0.9	neutral	-1.88	neutral	-0.91	medium_impact	2.71	0.34	damaging	0.26	damaging	-0.09	1.79	neutral	0.39	0.5	NA	NA	0.46	neutral	0.52	disease	0.3	neutral	4	0.85	neutral	0.57	deleterious	-3	neutral	0.23	neutral	1.14	medium_impact	-0.21	medium_impact	1.44	medium_impact	0.40	0.8	68.72	18.96	0.63	P	0.54	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8551	8551	T	C	MI.54	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	25	9	F	L	Ttc/Ctc	0.59	0.99	0	probably_damaging	0.92	neutral	0.06	neutral	3.94	neutral	-0.84	deleterious	-5.27	medium_impact	2.34	0.57	damaging	0.59	neutral	3.79	23.40	deleterious	0.4	0.65	0.6	disease	0.77	disease	0.82	disease	0.8	disease	6	0.98	deleterious	0.07	neutral	1	deleterious	0.76	deleterious	-1.76	low_impact	-0.38	medium_impact	0.91	medium_impact	0.44	0.9	49.56	8.77	0.5	P	0.89	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8779	8779	C	G	MI.540	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	253	85	L	V	Ctc/Gtc	-20	0	0	probably_damaging	0.99	neutral	0.08	neutral	4.17	neutral	-1.48	deleterious	-2.75	medium_impact	2.7	0.94	neutral	0.17	damaging	3.36	22.90	deleterious	0.47	0.65	0.59	disease	0.53	disease	0.61	disease	0.53	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.75	deleterious	-2.65	low_impact	-0.31	medium_impact	1.22	medium_impact	0.59	0.9	49.56	8.74	0.38	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7685	7685	A	T	MI.5400	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	100	34	I	F	Atc/Ttc	-2.01	0	0	possibly_damaging	0.84	neutral	0.15	neutral	0.57	deleterious	-5.71	deleterious	-3.95	high_impact	4.04	0.29	damaging	0.24	damaging	3.54	23.10	deleterious	0.3	0.45	NA	NA	0.86	disease	0.72	disease	0.72	disease	4	0.92	neutral	0.16	neutral	1	deleterious	0.83	deleterious	-1.39	low_impact	-0.21	medium_impact	2.68	high_impact	0.62	0.8	68.72	18.96	0.75	P	0.92	polymorphism	0.86	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7686	7686	T	G	MI.5401	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	101	34	I	S	aTc/aGc	6.75	1	0	probably_damaging	0.92	neutral	0.1	neutral	0.55	deleterious	-7.45	deleterious	-5.88	high_impact	4.59	0.29	damaging	0.31	neutral	4.01	23.60	deleterious	0.22	0.45	NA	NA	0.86	disease	0.69	disease	0.71	disease	4	0.97	neutral	0.09	neutral	2	deleterious	0.83	deleterious	-1.71	low_impact	-0.32	medium_impact	3.2	high_impact	0.42	0.8	68.72	18.96	0.87	P	0.91	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7686	7686	T	A	MI.5402	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	101	34	I	N	aTc/aAc	6.75	1	0	probably_damaging	0.98	deleterious	0.03	neutral	0.54	deleterious	-8.51	deleterious	-6.86	high_impact	4.04	0.31	damaging	0.23	damaging	4.22	23.90	deleterious	0.2	0.45	NA	NA	0.86	disease	0.72	disease	0.72	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.86	deleterious	-2.3	low_impact	-0.63	medium_impact	2.68	high_impact	0.54	0.8	68.72	18.96	0.68	P	0.99	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7686	7686	T	C	MI.5403	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	101	34	I	T	aTc/aCc	6.75	1	0	possibly_damaging	0.78	neutral	0.13	neutral	0.57	deleterious	-5.44	deleterious	-4.86	medium_impact	3.44	0.34	damaging	0.26	damaging	3.05	22.40	deleterious	0.32	0.5	NA	NA	0.73	disease	0.65	disease	0.57	disease	1	0.91	neutral	0.18	neutral	0	NA	0.74	deleterious	-1.23	low_impact	-0.25	medium_impact	2.12	high_impact	0.54	0.8	68.72	18.96	0.7	P	0.96	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7687	7687	C	G	MI.5404	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	102	34	I	M	atC/atG	7.44	1	0	probably_damaging	0.92	neutral	0.11	neutral	0.58	deleterious	-5.2	deleterious	-2.92	high_impact	3.56	0.33	damaging	0.35	neutral	3.14	22.60	deleterious	0.31	0.45	NA	NA	0.71	disease	0.66	disease	0.55	disease	1	0.97	neutral	0.1	neutral	2	deleterious	0.77	deleterious	-1.71	low_impact	-0.3	medium_impact	2.23	high_impact	0.64	0.8	68.72	18.96	0.73	P	0.79	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7687	7687	C	A	MI.5405	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	102	34	I	M	atC/atA	7.44	1	0	probably_damaging	0.92	neutral	0.11	neutral	0.58	deleterious	-5.2	deleterious	-2.92	high_impact	3.56	0.33	damaging	0.35	neutral	3.49	23.10	deleterious	0.31	0.45	NA	NA	0.71	disease	0.66	disease	0.55	disease	1	0.97	neutral	0.1	neutral	2	deleterious	0.77	deleterious	-1.71	low_impact	-0.3	medium_impact	2.23	high_impact	0.64	0.8	68.72	18.96	0.73	P	0.79	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7688	7688	T	C	MI.5406	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	103	35	C	R	Tgc/Cgc	-4.09	0	0	benign	0.11	neutral	0.34	neutral	1.59	neutral	-1.44	neutral	-0.7	low_impact	1.28	0.6	damaging	0.55	neutral	1.39	12.73	neutral	0.25	0.45	NA	NA	0.9	disease	0.67	disease	0.77	disease	5	0.61	neutral	0.62	deleterious	-6	neutral	0.36	neutral	0.13	medium_impact	0.05	medium_impact	0.1	medium_impact	0.35	0.8	63.44	17.24	0.31	N	0.64	disease_causing	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7688	7688	T	A	MI.5407	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	103	35	C	S	Tgc/Agc	-4.09	0	0	benign	0	neutral	0.52	neutral	1.67	neutral	0.23	neutral	3.88	neutral_impact	-2.03	0.85	neutral	0.95	neutral	-1.37	0.00	neutral	0.3	0.45	NA	NA	0.23	neutral	0.32	neutral	0.14	neutral	7	0.48	neutral	0.76	deleterious	-6	neutral	0.15	neutral	2.08	high_impact	0.22	medium_impact	-3.01	low_impact	0.58	0.8	63.44	17.24	0.25	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7688	7688	T	G	MI.5408	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	103	35	C	G	Tgc/Ggc	-4.09	0	0	benign	0.02	neutral	0.35	neutral	1.58	neutral	-0.62	neutral	0.14	neutral_impact	0.31	0.67	neutral	0.6	neutral	1.15	11.48	neutral	0.28	0.45	NA	NA	0.69	disease	0.47	neutral	0.37	neutral	3	0.63	neutral	0.67	deleterious	-6	neutral	0.23	neutral	0.86	medium_impact	0.06	medium_impact	-0.82	medium_impact	0.52	0.8	63.44	17.24	0.36	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7689	7689	G	T	MI.5409	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	104	35	C	F	tGc/tTc	5.6	1	0	benign	0.28	neutral	0.76	neutral	1.7	neutral	0.15	neutral	-1.53	neutral_impact	-0.45	0.61	neutral	0.64	neutral	1.93	15.76	deleterious	0.27	0.45	NA	NA	0.83	disease	0.56	disease	0.71	disease	4	0.18	neutral	0.74	deleterious	-6	neutral	0.36	neutral	-0.34	medium_impact	0.48	medium_impact	-1.53	low_impact	0.52	0.8	63.44	17.24	0.41	N	0.76	disease_causing	0.73	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8779	8779	C	A	MI.541	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	253	85	L	I	Ctc/Atc	-20	0	0	probably_damaging	0.99	neutral	0.11	neutral	4.24	neutral	-0.67	neutral	-1.83	low_impact	1.34	0.89	neutral	0.17	damaging	4.02	23.60	deleterious	0.41	0.65	0.44	neutral	0.51	disease	0.38	neutral	0.33	neutral	3	0.99	deleterious	0.06	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	-0.22	medium_impact	0.05	medium_impact	0.55	0.9	49.56	8.74	0.38	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7689	7689	G	A	MI.5410	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	104	35	C	Y	tGc/tAc	5.6	1	0	benign	0.28	neutral	1	neutral	1.59	neutral	-1.07	neutral	-1.53	low_impact	1.28	0.75	neutral	0.67	neutral	1.63	14.03	neutral	0.28	0.45	NA	NA	0.78	disease	0.58	disease	0.72	disease	4	0.28	neutral	0.86	deleterious	-6	neutral	0.36	neutral	-0.34	medium_impact	1.86	high_impact	0.1	medium_impact	0.47	0.8	63.44	17.24	0.42	N	0.76	disease_causing	0.51	0.04	.	.	.	.	.	.	COSM1636835	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7689	7689	G	C	MI.5411	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	104	35	C	S	tGc/tCc	5.6	1	0	benign	0	neutral	0.52	neutral	1.67	neutral	0.23	neutral	3.88	neutral_impact	-2.03	0.85	neutral	0.95	neutral	-1.65	0.00	neutral	0.3	0.45	NA	NA	0.23	neutral	0.32	neutral	0.14	neutral	7	0.48	neutral	0.76	deleterious	-6	neutral	0.15	neutral	2.08	high_impact	0.22	medium_impact	-3.01	low_impact	0.58	0.8	63.44	17.24	0.5	N	0.06	polymorphism	0.67	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7690	7690	C	G	MI.5412	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	105	35	C	W	tgC/tgG	9.29	1	0	possibly_damaging	0.65	neutral	0.18	neutral	1.56	neutral	-1.93	neutral	-2.45	low_impact	0.94	0.64	neutral	0.52	neutral	3.76	23.30	deleterious	0.2	0.45	NA	NA	0.87	disease	0.62	disease	0.77	disease	5	0.84	neutral	0.27	neutral	-3	neutral	0.69	deleterious	-0.97	medium_impact	-0.16	medium_impact	-0.22	medium_impact	0.32	0.8	63.44	17.24	0.45	N	0.78	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7690	7690	C	A	MI.5413	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	105	35	C	W	tgC/tgA	9.29	1	0	possibly_damaging	0.65	neutral	0.18	neutral	1.56	neutral	-1.93	neutral	-2.45	low_impact	0.94	0.64	neutral	0.52	neutral	4.06	23.70	deleterious	0.2	0.45	NA	NA	0.87	disease	0.62	disease	0.77	disease	5	0.84	neutral	0.27	neutral	-3	neutral	0.69	deleterious	-0.97	medium_impact	-0.16	medium_impact	-0.22	medium_impact	0.32	0.8	63.44	17.24	0.45	N	0.78	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7691	7691	T	G	MI.5414	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	106	36	F	V	Ttc/Gtc	-0.86	0.03	0	benign	0.27	neutral	0.57	neutral	1.68	neutral	-0.56	neutral	1.71	neutral_impact	-0.64	0.75	neutral	0.75	neutral	0.82	9.58	deleterious	0.27	0.45	NA	NA	0.31	neutral	0.26	neutral	0.15	neutral	7	0.32	neutral	0.65	deleterious	-6	neutral	0.26	neutral	-0.32	medium_impact	0.27	medium_impact	-1.71	low_impact	0.57	0.8	29.52	57.04	0.27	N	0.69	polymorphism	0.83	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7691	7691	T	C	MI.5415	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	106	36	F	L	Ttc/Ctc	-0.86	0.03	0	benign	0.01	neutral	0.75	neutral	1.71	neutral	-0.66	neutral	0.85	neutral_impact	-0.42	0.79	neutral	0.48	neutral	1.95	15.91	deleterious	0.41	0.5	NA	NA	0.45	neutral	0.31	neutral	0.15	neutral	7	0.23	neutral	0.87	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.47	medium_impact	-1.5	low_impact	0.42	0.8	29.52	57.04	0.21	N	0.57	polymorphism	0.91	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7691	7691	T	A	MI.5416	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	106	36	F	I	Ttc/Atc	-0.86	0.03	0	benign	0.18	neutral	1	neutral	1.72	neutral	-1.25	neutral	1.27	neutral_impact	-1.09	0.71	neutral	0.78	neutral	1.06	10.97	neutral	0.25	0.45	NA	NA	0.22	neutral	0.25	neutral	0.15	neutral	7	0.18	neutral	0.91	deleterious	-6	neutral	0.23	neutral	-0.11	medium_impact	1.86	high_impact	-2.13	low_impact	0.54	0.8	29.52	57.04	0.24	N	0.47	polymorphism	0.91	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7692	7692	T	C	MI.5417	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	107	36	F	S	tTc/tCc	2.83	0.89	0	possibly_damaging	0.73	neutral	0.61	neutral	1.62	neutral	-2.14	neutral	2.01	neutral_impact	-1.34	0.78	neutral	0.95	neutral	2.11	16.94	deleterious	0.33	0.5	NA	NA	0.25	neutral	0.34	neutral	0.13	neutral	7	0.68	neutral	0.44	neutral	-3	neutral	0.53	deleterious	-1.12	low_impact	0.31	medium_impact	-2.36	low_impact	0.57	0.8	29.52	57.04	0.32	N	0.03	polymorphism	1	0.01	rs370059789	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7692	7692	T	G	MI.5418	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	107	36	F	C	tTc/tGc	2.83	0.89	0	probably_damaging	0.93	neutral	0.06	neutral	1.54	deleterious	-3.43	neutral	0.33	neutral_impact	0.44	0.64	neutral	0.44	neutral	3.86	23.50	deleterious	0.2	0.45	NA	NA	0.62	disease	0.35	neutral	0.41	neutral	2	0.98	deleterious	0.07	neutral	-2	neutral	0.73	deleterious	-1.77	low_impact	-0.46	medium_impact	-0.69	medium_impact	0.39	0.8	29.52	57.04	0.4	N	0.58	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7692	7692	T	A	MI.5419	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	107	36	F	Y	tTc/tAc	2.83	0.89	0	possibly_damaging	0.49	neutral	0.28	neutral	1.53	deleterious	-3.23	neutral	-0.24	low_impact	1.17	0.71	neutral	0.6	neutral	3.76	23.40	deleterious	0.27	0.45	NA	NA	0.39	neutral	0.5	neutral	0.13	neutral	7	0.69	neutral	0.4	neutral	-3	neutral	0.51	deleterious	-0.7	medium_impact	-0.02	medium_impact	-0.01	medium_impact	0.59	0.8	29.52	57.04	0.45	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8779	8779	C	T	MI.542	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	253	85	L	F	Ctc/Ttc	-20	0	0	probably_damaging	1	neutral	0.1	neutral	4.12	neutral	-1.38	deleterious	-3.66	medium_impact	2.04	0.93	neutral	0.16	damaging	3.90	23.50	deleterious	0.45	0.65	0.7	disease	0.62	disease	0.43	neutral	0.37	neutral	3	1	deleterious	0.05	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.25	medium_impact	0.65	medium_impact	0.51	0.9	49.56	8.74	0.36	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7693	7693	C	A	MI.5420	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	108	36	F	L	ttC/ttA	3.06	0.89	0	benign	0.01	neutral	0.75	neutral	1.71	neutral	-0.66	neutral	0.85	neutral_impact	-0.42	0.79	neutral	0.48	neutral	2.56	19.85	deleterious	0.41	0.5	NA	NA	0.45	neutral	0.31	neutral	0.15	neutral	7	0.23	neutral	0.87	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.47	medium_impact	-1.5	low_impact	0.42	0.8	29.52	57.04	0.23	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7693	7693	C	G	MI.5421	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	108	36	F	L	ttC/ttG	3.06	0.89	0	benign	0.01	neutral	0.75	neutral	1.71	neutral	-0.66	neutral	0.85	neutral_impact	-0.42	0.79	neutral	0.48	neutral	2.23	17.71	deleterious	0.41	0.5	NA	NA	0.45	neutral	0.31	neutral	0.15	neutral	7	0.23	neutral	0.87	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.47	medium_impact	-1.5	low_impact	0.42	0.8	29.52	57.04	0.23	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7694	7694	C	A	MI.5422	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	109	37	L	M	Cta/Ata	-7.55	0	0	probably_damaging	1	neutral	0.21	neutral	1.29	neutral	-2.15	neutral	-1.02	low_impact	1.01	0.69	neutral	0.74	neutral	2.36	18.54	deleterious	0.25	0.45	NA	NA	0.2	neutral	0.36	neutral	0.2	neutral	6	1	deleterious	0.11	neutral	-2	neutral	0.73	deleterious	-3.52	low_impact	-0.11	medium_impact	-0.16	medium_impact	0.54	0.8	68.28	18.34	0.46	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7694	7694	C	G	MI.5423	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	109	37	L	V	Cta/Gta	-7.55	0	0	probably_damaging	0.99	neutral	0.4	neutral	1.37	neutral	-0.18	neutral	-1.91	low_impact	1.41	0.59	damaging	0.47	neutral	2.11	16.92	deleterious	0.26	0.45	NA	NA	0.35	neutral	0.37	neutral	0.16	neutral	7	0.99	deleterious	0.21	neutral	-2	neutral	0.76	deleterious	-2.58	low_impact	0.11	medium_impact	0.22	medium_impact	0.52	0.8	68.28	18.34	0.36	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7695	7695	T	C	MI.5424	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	110	37	L	P	cTa/cCa	-5.24	0	0	probably_damaging	1	deleterious	0.02	neutral	1.24	deleterious	-4.08	deleterious	-5.8	medium_impact	3.23	0.38	damaging	0.29	neutral	3.73	23.30	deleterious	0.11	0.4	NA	NA	0.86	disease	0.7	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.89	deleterious	-3.52	low_impact	-0.73	medium_impact	1.92	medium_impact	0.46	0.8	68.28	18.34	0.46	N	0.99	disease_causing	0.98	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7695	7695	T	G	MI.5425	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	110	37	L	R	cTa/cGa	-5.24	0	0	probably_damaging	1	neutral	0.08	neutral	1.25	deleterious	-3.63	deleterious	-5.03	high_impact	3.79	0.44	damaging	0.26	damaging	3.99	23.60	deleterious	0.12	0.4	NA	NA	0.89	disease	0.7	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.38	medium_impact	2.45	high_impact	0.40	0.8	68.28	18.34	0.41	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7695	7695	T	A	MI.5426	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	110	37	L	Q	cTa/cAa	-5.24	0	0	probably_damaging	1	neutral	0.09	neutral	1.24	deleterious	-3.8	deleterious	-4.83	medium_impact	3.1	0.54	damaging	0.38	neutral	3.90	23.50	deleterious	0.12	0.4	NA	NA	0.68	disease	0.58	disease	0.68	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.35	medium_impact	1.8	medium_impact	0.43	0.8	68.28	18.34	0.34	N	0.95	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7697	7697	G	C	MI.5427	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	112	38	V	L	Gtc/Ctc	-0.63	0.1	0	benign	0.17	deleterious	0.04	neutral	0.49	deleterious	-4.09	deleterious	-2.81	medium_impact	2.73	0.35	damaging	0.41	neutral	1.53	13.45	neutral	0.33	0.5	NA	NA	0.83	disease	0.6	disease	0.57	disease	1	0.95	neutral	0.44	neutral	1	deleterious	0.33	neutral	-0.08	medium_impact	-0.56	medium_impact	1.45	medium_impact	0.34	0.8	66.96	16.57	0.56	P	0.23	polymorphism	0.64	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7697	7697	G	T	MI.5428	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	112	38	V	F	Gtc/Ttc	-0.63	0.1	0	probably_damaging	0.92	neutral	0.35	neutral	0.4	deleterious	-6.31	deleterious	-4.77	high_impact	3.91	0.33	damaging	0.33	neutral	3.62	23.20	deleterious	0.2	0.45	NA	NA	0.92	disease	0.65	disease	0.72	disease	4	0.93	neutral	0.22	neutral	2	deleterious	0.84	deleterious	-1.71	low_impact	0.06	medium_impact	2.56	high_impact	0.49	0.8	66.96	16.57	0.53	P	0.94	disease_causing	0.86	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7697	7697	G	A	MI.5429	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	112	38	V	I	Gtc/Atc	-0.63	0.1	0	benign	0.03	neutral	0.25	neutral	0.63	neutral	-2.78	neutral	-0.84	low_impact	1.68	0.59	damaging	0.57	neutral	0.44	6.93	deleterious	0.33	0.5	NA	NA	0.57	disease	0.51	disease	0.19	neutral	6	0.74	neutral	0.61	deleterious	-6	neutral	0.22	neutral	0.69	medium_impact	-0.06	medium_impact	0.47	medium_impact	0.57	0.8	66.96	16.57	0.55	P	0.30	polymorphism	0.86	0.03	rs879212765	.	.	.	.	.	.	.	.	G7697A	Possible HCM susceptibility	+	-	Reported	3	N	P	N,P	neutral
chrM	8780	8780	T	A	MI.543	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	254	85	L	H	cTc/cAc	-4.04	0	0	probably_damaging	1	deleterious	0.01	neutral	4.07	deleterious	-4.72	deleterious	-6.43	high_impact	3.8	0.84	neutral	0.13	damaging	4.09	23.70	deleterious	0.23	0.65	0.88	disease	0.79	disease	0.7	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	2.16	high_impact	0.55	0.9	49.56	8.74	0.31	N	0.97	polymorphism	0.63	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7698	7698	T	G	MI.5430	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	113	38	V	G	gTc/gGc	6.29	1	0	probably_damaging	1	neutral	0.08	neutral	0.39	deleterious	-7.31	deleterious	-6.87	high_impact	4.46	0.37	damaging	0.43	neutral	3.67	23.20	deleterious	0.17	0.45	NA	NA	0.86	disease	0.68	disease	0.71	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.38	medium_impact	3.08	high_impact	0.37	0.8	66.96	16.57	0.71	P	0.84	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7698	7698	T	A	MI.5431	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	113	38	V	D	gTc/gAc	6.29	1	0	probably_damaging	1	deleterious	0.01	neutral	0.39	deleterious	-8.09	deleterious	-6.8	high_impact	4.46	0.35	damaging	0.31	neutral	4.49	24.30	deleterious	0.09	0.35	NA	NA	0.9	disease	0.78	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.52	low_impact	-0.9	medium_impact	3.08	high_impact	0.55	0.8	66.96	16.57	0.7	P	0.90	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7698	7698	T	C	MI.5432	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	113	38	V	A	gTc/gCc	6.29	1	0	possibly_damaging	0.79	deleterious	0.03	neutral	0.43	deleterious	-5.28	deleterious	-3.92	high_impact	3.91	0.42	damaging	0.45	neutral	3.31	22.90	deleterious	0.28	0.45	NA	NA	0.63	disease	0.66	disease	0.66	disease	3	0.98	neutral	0.12	neutral	5	deleterious	0.67	deleterious	-1.26	low_impact	-0.63	medium_impact	2.56	high_impact	0.28	0.8	66.96	16.57	0.73	P	0.59	disease_causing	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7700	7700	C	G	MI.5433	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	115	39	L	V	Ctg/Gtg	-15.85	0	0	probably_damaging	0.97	neutral	0.48	neutral	1.47	neutral	-0.52	neutral	-2.37	medium_impact	2.4	0.36	damaging	0.07	damaging	3.23	22.80	deleterious	0.43	0.55	NA	NA	0.43	neutral	0.39	neutral	0.21	neutral	6	0.97	neutral	0.26	neutral	1	deleterious	0.75	deleterious	-2.13	low_impact	0.19	medium_impact	1.15	medium_impact	0.51	0.8	68.72	19.1	0.41	N	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7700	7700	C	A	MI.5434	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	115	39	L	M	Ctg/Atg	-15.85	0	0	probably_damaging	1	neutral	0.22	neutral	1.42	neutral	-2.11	neutral	-1.52	medium_impact	2.11	0.43	damaging	0.06	damaging	3.55	23.10	deleterious	0.29	0.45	NA	NA	0.31	neutral	0.29	neutral	0.19	neutral	6	1	deleterious	0.11	neutral	1	deleterious	0.74	deleterious	-3.52	low_impact	-0.1	medium_impact	0.87	medium_impact	0.52	0.8	68.72	19.1	0.36	N	0.78	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7701	7701	T	A	MI.5435	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	116	39	L	Q	cTg/cAg	0.06	0	0	probably_damaging	1	neutral	0.13	neutral	1.4	deleterious	-3.78	deleterious	-5.16	high_impact	3.9	0.35	damaging	0.04	damaging	4.02	23.60	deleterious	0.19	0.45	NA	NA	0.63	disease	0.42	neutral	0.47	neutral	1	1	deleterious	0.07	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	-0.25	medium_impact	2.55	high_impact	0.58	0.8	68.72	19.1	0.42	N	0.95	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7701	7701	T	C	MI.5436	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	116	39	L	P	cTg/cCg	0.06	0	0	probably_damaging	1	neutral	0.09	neutral	1.38	deleterious	-4.33	deleterious	-6.11	high_impact	3.9	0.14	damaging	0.02	damaging	3.71	23.30	deleterious	0.15	0.4	NA	NA	0.86	disease	0.59	disease	0.71	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.35	medium_impact	2.55	high_impact	0.57	0.8	68.72	19.1	0.71	P	0.99	polymorphism	0.76	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7701	7701	T	G	MI.5437	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	116	39	L	R	cTg/cGg	0.06	0	0	probably_damaging	1	neutral	0.15	neutral	1.4	deleterious	-3.63	deleterious	-5.23	high_impact	3.9	0.19	damaging	0.02	damaging	4.01	23.60	deleterious	0.18	0.45	NA	NA	0.87	disease	0.56	disease	0.69	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.21	medium_impact	2.55	high_impact	0.56	0.8	68.72	19.1	0.7	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7703	7703	T	G	MI.5438	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	118	40	Y	D	Tat/Gat	-20	0	0	probably_damaging	1	deleterious	0.02	neutral	1.33	deleterious	-4	deleterious	-9.75	high_impact	3.83	0.18	damaging	0.03	damaging	3.77	23.40	deleterious	0.3	0.45	NA	NA	0.91	disease	0.69	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.52	low_impact	-0.73	medium_impact	2.49	high_impact	0.28	0.8	68.28	19.11	0.48	P	0.99	polymorphism	0.99	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7703	7703	T	A	MI.5439	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	118	40	Y	N	Tat/Aat	-20	0	0	probably_damaging	1	deleterious	0.03	neutral	1.34	deleterious	-3.16	deleterious	-8.76	high_impact	4.03	0.15	damaging	0.02	damaging	3.85	23.40	deleterious	0.43	0.55	NA	NA	0.89	disease	0.61	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-3.52	low_impact	-0.63	medium_impact	2.67	high_impact	0.26	0.8	68.28	19.11	0.51	P	0.99	polymorphism	0.99	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8780	8780	T	G	MI.544	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	254	85	L	R	cTc/cGc	-4.04	0	0	probably_damaging	1	deleterious	0.01	neutral	4.08	deleterious	-4.19	deleterious	-5.51	high_impact	4.14	0.85	neutral	0.13	damaging	4.13	23.80	deleterious	0.23	0.65	0.84	disease	0.87	disease	0.74	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-0.84	medium_impact	2.45	high_impact	0.62	0.9	49.56	8.74	0.33	N	0.99	disease_causing	0.52	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7703	7703	T	C	MI.5440	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	118	40	Y	H	Tat/Cat	-20	0	0	probably_damaging	1	neutral	0.18	neutral	1.34	deleterious	-3.51	deleterious	-4.79	high_impact	4.03	0.15	damaging	0.03	damaging	3.34	22.90	deleterious	0.48	0.55	NA	NA	0.87	disease	0.65	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.16	medium_impact	2.67	high_impact	0.33	0.8	68.28	19.11	0.54	P	0.94	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7704	7704	A	C	MI.5441	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	119	40	Y	S	tAt/tCt	7.44	1	0	probably_damaging	1	neutral	0.13	neutral	1.37	neutral	-1.72	deleterious	-8.78	medium_impact	3.34	0.13	damaging	0.03	damaging	3.71	23.30	deleterious	0.35	0.5	NA	NA	0.87	disease	0.6	disease	0.69	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	-0.25	medium_impact	2.03	high_impact	0.33	0.8	68.28	19.11	0.82	P	0.99	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7704	7704	A	G	MI.5442	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	119	40	Y	C	tAt/tGt	7.44	1	0	probably_damaging	1	neutral	0.06	neutral	1.35	deleterious	-3.4	deleterious	-8.8	high_impact	3.57	0.13	damaging	0.02	damaging	3.43	23.00	deleterious	0.43	0.55	NA	NA	0.9	disease	0.65	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.46	medium_impact	2.24	high_impact	0.16	0.8	68.28	19.11	0.82	P	0.96	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7704	7704	A	T	MI.5443	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	119	40	Y	F	tAt/tTt	7.44	1	0	probably_damaging	0.98	neutral	0.31	neutral	1.39	neutral	0.18	deleterious	-3.92	medium_impact	2.45	0.16	damaging	0.02	damaging	3.34	22.90	deleterious	0.34	0.5	NA	NA	0.82	disease	0.45	neutral	0.19	neutral	6	0.98	deleterious	0.17	neutral	1	deleterious	0.87	deleterious	-2.3	low_impact	0.01	medium_impact	1.19	medium_impact	0.28	0.8	68.28	19.11	0.87	P	0.87	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7706	7706	G	A	MI.5444	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	121	41	A	T	Gcc/Acc	-2.48	0	0	possibly_damaging	0.46	neutral	0.41	neutral	1.53	neutral	-0.85	neutral	0.32	neutral_impact	-0.55	0.83	neutral	0.75	neutral	1.28	12.17	neutral	0.57	0.65	NA	NA	0.17	neutral	0.29	neutral	0.22	neutral	6	0.55	neutral	0.48	deleterious	-3	neutral	0.38	neutral	-0.66	medium_impact	0.12	medium_impact	-1.62	low_impact	0.77	0.85	28.63	41.18	0.35	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	G7706A	Alpers-Huttenlocher-like	NA	+	Reported	1	.	P	P	neutral
chrM	7706	7706	G	T	MI.5445	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	121	41	A	S	Gcc/Tcc	-2.48	0	0	possibly_damaging	0.62	neutral	0.35	neutral	1.53	neutral	-0.97	neutral	-0.72	neutral_impact	0.05	0.71	neutral	0.68	neutral	3.16	22.60	deleterious	0.53	0.6	NA	NA	0.3	neutral	0.29	neutral	0.16	neutral	7	0.69	neutral	0.37	neutral	-3	neutral	0.46	deleterious	-0.92	medium_impact	0.06	medium_impact	-1.06	low_impact	0.80	0.85	28.63	41.18	0.4	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7706	7706	G	C	MI.5446	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	121	41	A	P	Gcc/Ccc	-2.48	0	0	possibly_damaging	0.9	neutral	0.17	neutral	1.48	neutral	-2.77	neutral	-1.95	low_impact	1.52	0.53	damaging	0.38	neutral	3.61	23.20	deleterious	0.24	0.45	NA	NA	0.78	disease	0.67	disease	0.74	disease	5	0.95	neutral	0.14	neutral	-3	neutral	0.80	deleterious	-1.61	low_impact	-0.18	medium_impact	0.32	medium_impact	0.86	0.9	28.63	41.18	0.33	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7707	7707	C	A	MI.5447	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	122	41	A	D	gCc/gAc	0.75	0.09	0	possibly_damaging	0.86	neutral	0.21	neutral	1.47	deleterious	-3.23	neutral	-2.12	low_impact	1.52	0.58	damaging	0.45	neutral	4.21	23.90	deleterious	0.26	0.45	NA	NA	0.69	disease	0.66	disease	0.71	disease	4	0.91	neutral	0.18	neutral	-3	neutral	0.72	deleterious	-1.46	low_impact	-0.11	medium_impact	0.32	medium_impact	0.70	0.85	28.63	41.18	0.39	N	0.74	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7707	7707	C	G	MI.5448	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	122	41	A	G	gCc/gGc	0.75	0.09	0	possibly_damaging	0.69	neutral	0.24	neutral	1.5	neutral	-1.8	deleterious	-2.58	low_impact	1.18	0.68	neutral	0.66	neutral	2.50	19.47	deleterious	0.46	0.55	NA	NA	0.38	neutral	0.41	neutral	0.15	neutral	7	0.81	neutral	0.28	neutral	-3	neutral	0.54	deleterious	-1.04	low_impact	-0.07	medium_impact	0	medium_impact	0.76	0.85	28.63	41.18	0.47	N	0.68	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7707	7707	C	T	MI.5449	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	122	41	A	V	gCc/gTc	0.75	0.09	0	benign	0.02	neutral	0.44	neutral	1.68	neutral	0.87	neutral	2.59	neutral_impact	-0.42	0.9	neutral	0.93	neutral	1.09	11.19	neutral	0.58	0.65	NA	NA	0.28	neutral	0.3	neutral	0.16	neutral	7	0.54	neutral	0.71	deleterious	-6	neutral	0.17	neutral	0.86	medium_impact	0.15	medium_impact	-1.5	low_impact	0.82	0.85	28.63	41.18	0.38	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8780	8780	T	C	MI.545	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	254	85	L	P	cTc/cCc	-4.04	0	0	probably_damaging	1	deleterious	0.01	neutral	4.07	deleterious	-3.91	deleterious	-6.47	high_impact	3.8	0.83	neutral	0.14	damaging	3.84	23.40	deleterious	0.17	0.65	0.88	disease	0.81	disease	0.74	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-0.84	medium_impact	2.16	high_impact	0.58	0.9	49.56	8.74	0.31	N	1.00	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7709	7709	C	G	MI.5450	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	124	42	L	V	Ctt/Gtt	-2.94	0	0	probably_damaging	0.99	neutral	0.47	neutral	1.14	neutral	-2.49	neutral	0.42	low_impact	1.72	0.53	damaging	0.27	damaging	3.32	22.90	deleterious	0.55	0.6	NA	NA	0.39	neutral	0.56	disease	0.35	neutral	3	0.99	deleterious	0.24	neutral	-2	neutral	0.78	deleterious	-2.58	low_impact	0.18	medium_impact	0.51	medium_impact	0.75	0.85	28.19	63.57	0.41	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7709	7709	C	A	MI.5451	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	124	42	L	I	Ctt/Att	-2.94	0	0	probably_damaging	0.99	neutral	0.7	neutral	1.22	neutral	-1.63	neutral	1.33	neutral_impact	-0.87	0.75	neutral	0.97	neutral	1.30	12.25	neutral	0.51	0.6	NA	NA	0.08	neutral	0.27	neutral	0.22	neutral	6	0.99	deleterious	0.36	neutral	-2	neutral	0.73	deleterious	-2.58	low_impact	0.41	medium_impact	-1.92	low_impact	0.72	0.85	28.19	63.57	0.33	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7709	7709	C	T	MI.5452	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	124	42	L	F	Ctt/Ttt	-2.94	0	0	probably_damaging	1	neutral	0.55	neutral	1.11	neutral	-2.8	neutral	-2.21	low_impact	1.22	0.48	damaging	0.25	damaging	3.79	23.40	deleterious	0.53	0.6	NA	NA	0.55	disease	0.4	neutral	0.38	neutral	2	1	deleterious	0.28	neutral	-2	neutral	0.80	deleterious	-3.52	low_impact	0.25	medium_impact	0.04	medium_impact	0.75	0.85	28.19	63.57	0.32	N	0.35	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7710	7710	T	A	MI.5453	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	125	42	L	H	cTt/cAt	1.21	0.51	0	probably_damaging	1	neutral	0.19	neutral	1.03	deleterious	-5.61	deleterious	-5.03	medium_impact	2.35	0.53	damaging	0.2	damaging	3.87	23.50	deleterious	0.29	0.45	NA	NA	0.62	disease	0.52	disease	0.57	disease	1	1	deleterious	0.1	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	-0.14	medium_impact	1.1	medium_impact	0.61	0.8	28.19	63.57	0.34	N	0.82	disease_causing	0.74	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7710	7710	T	G	MI.5454	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	125	42	L	R	cTt/cGt	1.21	0.51	0	probably_damaging	1	neutral	0.12	neutral	1.04	deleterious	-5.02	deleterious	-4.88	medium_impact	2.35	0.44	damaging	0.18	damaging	3.97	23.60	deleterious	0.34	0.5	NA	NA	0.86	disease	0.7	disease	0.76	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.89	deleterious	-3.52	low_impact	-0.27	medium_impact	1.1	medium_impact	0.66	0.8	28.19	63.57	0.42	N	0.93	disease_causing	0.84	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7710	7710	T	C	MI.5455	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	125	42	L	P	cTt/cCt	1.21	0.51	0	probably_damaging	1	neutral	0.07	neutral	1.03	deleterious	-5.59	deleterious	-5.03	medium_impact	2.69	0.42	damaging	0.18	damaging	3.61	23.20	deleterious	0.26	0.45	NA	NA	0.85	disease	0.71	disease	0.76	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.90	deleterious	-3.52	low_impact	-0.42	medium_impact	1.42	medium_impact	0.70	0.85	28.19	63.57	0.44	N	0.97	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7712	7712	T	C	MI.5456	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	127	43	F	L	Ttc/Ctc	-2.24	0	0	benign	0	neutral	0.66	neutral	1.68	neutral	-0.48	neutral	1.01	neutral_impact	-0.46	0.81	neutral	0.75	neutral	-0.07	1.94	neutral	0.54	0.6	NA	NA	0.27	neutral	0.26	neutral	0.16	neutral	7	0.33	neutral	0.83	deleterious	-6	neutral	0.12	neutral	2.08	high_impact	0.36	medium_impact	-1.54	low_impact	0.43	0.8	30.84	24.7	0.27	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7712	7712	T	A	MI.5457	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	127	43	F	I	Ttc/Atc	-2.24	0	0	benign	0.09	neutral	0.92	neutral	1.63	neutral	-0.58	neutral	1.48	neutral_impact	-0.66	0.75	neutral	0.85	neutral	0.28	5.48	deleterious	0.29	0.45	NA	NA	0.12	neutral	0.23	neutral	0.23	neutral	5	0.03	neutral	0.92	deleterious	-6	neutral	0.17	neutral	0.22	medium_impact	0.79	medium_impact	-1.72	low_impact	0.39	0.8	30.84	24.7	0.27	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7712	7712	T	G	MI.5458	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	127	43	F	V	Ttc/Gtc	-2.24	0	0	benign	0.14	neutral	0.61	neutral	1.76	neutral	-0.77	neutral	1.9	neutral_impact	-0.67	0.78	neutral	0.87	neutral	-0.64	0.10	neutral	0.39	0.5	NA	NA	0.23	neutral	0.26	neutral	0.16	neutral	7	0.28	neutral	0.74	deleterious	-6	neutral	0.19	neutral	0.01	medium_impact	0.31	medium_impact	-1.73	low_impact	0.32	0.8	30.84	24.7	0.23	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7713	7713	T	A	MI.5459	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	128	43	F	Y	tTc/tAc	-0.63	0	0	benign	0.42	neutral	0.47	neutral	1.53	neutral	-2.27	neutral	-0.23	low_impact	0.81	0.73	neutral	0.6	neutral	0.51	7.50	deleterious	0.34	0.5	NA	NA	0.31	neutral	0.33	neutral	0.15	neutral	7	0.48	neutral	0.53	deleterious	-6	neutral	0.41	neutral	-0.59	medium_impact	0.18	medium_impact	-0.35	medium_impact	0.39	0.8	30.84	24.7	0.38	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8782	8782	G	C	MI.546	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	256	86	G	R	Gga/Cga	0.13	0.93	0	probably_damaging	1	deleterious	0	neutral	3.68	deleterious	-6.97	deleterious	-7.35	high_impact	4.23	0.55	damaging	0.08	damaging	3.82	23.40	deleterious	0.21	0.65	0.85	disease	0.89	disease	0.83	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.53	high_impact	0.87	0.9	50.44	8.61	0.47	N	0.98	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7713	7713	T	G	MI.5460	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	128	43	F	C	tTc/tGc	-0.63	0	0	possibly_damaging	0.74	neutral	0.16	neutral	1.51	deleterious	-3.74	neutral	0.33	low_impact	1.65	0.67	neutral	0.44	neutral	2.55	19.77	deleterious	0.29	0.45	NA	NA	0.6	disease	0.47	neutral	0.47	neutral	1	0.88	neutral	0.21	neutral	-3	neutral	0.59	deleterious	-1.14	low_impact	-0.19	medium_impact	0.44	medium_impact	0.27	0.8	30.84	24.7	0.43	N	0.35	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7713	7713	T	C	MI.5461	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	128	43	F	S	tTc/tCc	-0.63	0	0	benign	0.01	neutral	0.51	neutral	1.56	neutral	-2.29	neutral	1.84	neutral_impact	-0.4	0.87	neutral	0.97	neutral	-0.14	1.45	neutral	0.46	0.55	NA	NA	0.24	neutral	0.35	neutral	0.14	neutral	7	0.47	neutral	0.75	deleterious	-6	neutral	0.14	neutral	1.14	medium_impact	0.21	medium_impact	-1.48	low_impact	0.34	0.8	30.84	24.7	0.3	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7714	7714	C	G	MI.5462	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	129	43	F	L	ttC/ttG	0.75	0	0	benign	0	neutral	0.66	neutral	1.68	neutral	-0.48	neutral	1.01	neutral_impact	-0.46	0.81	neutral	0.75	neutral	0.30	5.71	deleterious	0.54	0.6	NA	NA	0.27	neutral	0.26	neutral	0.16	neutral	7	0.33	neutral	0.83	deleterious	-6	neutral	0.12	neutral	2.08	high_impact	0.36	medium_impact	-1.54	low_impact	0.43	0.8	30.84	24.7	0.29	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7714	7714	C	A	MI.5463	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	129	43	F	L	ttC/ttA	0.75	0	0	benign	0	neutral	0.66	neutral	1.68	neutral	-0.48	neutral	1.01	neutral_impact	-0.46	0.81	neutral	0.75	neutral	0.63	8.37	deleterious	0.54	0.6	NA	NA	0.27	neutral	0.26	neutral	0.16	neutral	7	0.33	neutral	0.83	deleterious	-6	neutral	0.12	neutral	2.08	high_impact	0.36	medium_impact	-1.54	low_impact	0.43	0.8	30.84	24.7	0.29	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7715	7715	C	G	MI.5464	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	130	44	L	V	Cta/Gta	-4.55	0	0	benign	0.11	neutral	0.73	neutral	1.56	neutral	-0.33	neutral	-0.4	neutral_impact	0.79	0.78	neutral	0.8	neutral	-0.17	1.29	neutral	0.62	0.65	NA	NA	0.19	neutral	0.34	neutral	0.18	neutral	6	0.16	neutral	0.81	deleterious	-6	neutral	0.18	neutral	0.13	medium_impact	0.44	medium_impact	-0.37	medium_impact	0.39	0.8	28.19	26.29	0.25	N	0.39	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7715	7715	C	A	MI.5465	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	130	44	L	M	Cta/Ata	-4.55	0	0	possibly_damaging	0.8	neutral	0.8	neutral	1.5	neutral	-1.16	neutral	-0.35	neutral_impact	0.68	0.75	neutral	0.81	neutral	1.89	15.53	deleterious	0.32	0.5	NA	NA	0.06	neutral	0.22	neutral	0.2	neutral	6	0.77	neutral	0.5	deleterious	-3	neutral	0.57	deleterious	-1.28	low_impact	0.54	medium_impact	-0.47	medium_impact	0.61	0.8	28.19	26.29	0.33	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7716	7716	T	A	MI.5466	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	131	44	L	Q	cTa/cAa	-1.55	0	0	probably_damaging	0.94	neutral	0.35	neutral	1.47	neutral	-2.06	neutral	-1.85	medium_impact	2.77	0.69	neutral	0.46	neutral	2.65	20.50	deleterious	0.18	0.45	NA	NA	0.5	neutral	0.39	neutral	0.49	neutral	0	0.94	neutral	0.21	neutral	1	deleterious	0.73	deleterious	-1.83	low_impact	0.06	medium_impact	1.49	medium_impact	0.55	0.8	28.19	26.29	0.41	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7716	7716	T	G	MI.5467	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	131	44	L	R	cTa/cGa	-1.55	0	0	possibly_damaging	0.86	neutral	0.3	neutral	1.51	neutral	-1.04	neutral	-2.11	low_impact	0.88	0.61	neutral	0.35	neutral	2.64	20.50	deleterious	0.18	0.45	NA	NA	0.68	disease	0.53	disease	0.49	neutral	0	0.89	neutral	0.22	neutral	-3	neutral	0.77	deleterious	-1.46	low_impact	0	medium_impact	-0.28	medium_impact	0.54	0.8	28.19	26.29	0.29	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7716	7716	T	C	MI.5468	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	131	44	L	P	cTa/cCa	-1.55	0	0	probably_damaging	0.95	neutral	0.18	neutral	1.47	neutral	-2.33	neutral	-2.42	medium_impact	2.21	0.6	neutral	0.34	neutral	2.57	19.91	deleterious	0.08	0.35	NA	NA	0.76	disease	0.56	disease	0.7	disease	4	0.97	neutral	0.12	neutral	1	deleterious	0.82	deleterious	-1.91	low_impact	-0.16	medium_impact	0.97	medium_impact	0.52	0.8	28.19	26.29	0.3	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7718	7718	A	G	MI.5469	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	133	45	T	A	Aca/Gca	-20	0	0	benign	0.27	neutral	0.17	neutral	1.61	neutral	0.3	neutral	-0.82	neutral_impact	0.28	0.76	neutral	0.75	neutral	1.32	12.36	neutral	0.68	0.7	NA	NA	0.26	neutral	0.47	neutral	0.16	neutral	7	0.8	neutral	0.45	neutral	-6	neutral	0.25	neutral	-0.32	medium_impact	-0.18	medium_impact	-0.84	medium_impact	0.48	0.8	28.19	66.11	0.41	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8782	8782	G	T	MI.547	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	256	86	G	W	Gga/Tga	0.13	0.93	0	probably_damaging	1	deleterious	0	neutral	3.66	deleterious	-10.28	deleterious	-7.39	high_impact	4.58	0.59	damaging	0.08	damaging	4.33	24.00	deleterious	0.16	0.65	0.99	disease	0.87	disease	0.78	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.83	high_impact	0.43	0.9	50.44	8.61	0.46	N	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7718	7718	A	C	MI.5470	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	133	45	T	P	Aca/Cca	-20	0	0	possibly_damaging	0.8	neutral	0.12	neutral	1.5	neutral	-2.58	neutral	-2.01	low_impact	1.42	0.62	neutral	0.4	neutral	2.99	22.20	deleterious	0.29	0.45	NA	NA	0.83	disease	0.7	disease	0.78	disease	6	0.93	neutral	0.16	neutral	-3	neutral	0.77	deleterious	-1.28	low_impact	-0.27	medium_impact	0.23	medium_impact	0.63	0.8	28.19	66.11	0.32	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7718	7718	A	T	MI.5471	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	133	45	T	S	Aca/Tca	-20	0	0	benign	0.41	neutral	0.18	neutral	1.53	neutral	-1.03	neutral	-0.88	neutral_impact	0.46	0.67	neutral	0.64	neutral	1.36	12.59	neutral	0.69	0.75	NA	NA	0.37	neutral	0.34	neutral	0.15	neutral	7	0.79	neutral	0.39	neutral	-6	neutral	0.33	neutral	-0.57	medium_impact	-0.16	medium_impact	-0.67	medium_impact	0.62	0.8	28.19	66.11	0.44	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7719	7719	C	T	MI.5472	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	134	45	T	M	aCa/aTa	5.6	1	0	benign	0.08	neutral	0.68	neutral	1.65	neutral	0.7	neutral	3.25	neutral_impact	-1.72	0.73	neutral	0.97	neutral	-0.81	0.04	neutral	0.42	0.55	NA	NA	0.16	neutral	0.31	neutral	0.2	neutral	6	0.22	neutral	0.8	deleterious	-6	neutral	0.16	neutral	0.27	medium_impact	0.39	medium_impact	-2.72	low_impact	0.68	0.85	28.19	66.11	0.52	P	0.03	polymorphism	0.62	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7719	7719	C	A	MI.5473	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	134	45	T	K	aCa/aAa	5.6	1	0	possibly_damaging	0.53	neutral	0.05	neutral	1.51	neutral	-1.88	neutral	-1.22	medium_impact	2.11	0.61	neutral	0.52	neutral	2.63	20.40	deleterious	0.37	0.5	NA	NA	0.71	disease	0.66	disease	0.72	disease	4	0.95	neutral	0.26	neutral	0	NA	0.49	deleterious	-0.77	medium_impact	-0.5	medium_impact	0.87	medium_impact	0.62	0.8	28.19	66.11	0.58	P	0.48	disease_causing	0.53	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7721	7721	C	G	MI.5474	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	136	46	L	V	Ctc/Gtc	-0.17	0	0	probably_damaging	0.99	neutral	0.45	neutral	1.41	neutral	-0.94	neutral	-0.33	low_impact	0.8	0.78	neutral	0.68	neutral	0.74	9.10	deleterious	0.6	0.65	NA	NA	0.17	neutral	0.34	neutral	0.22	neutral	6	0.99	deleterious	0.23	neutral	-2	neutral	0.72	deleterious	-2.58	low_impact	0.16	medium_impact	-0.36	medium_impact	0.71	0.85	68.72	18.95	0.32	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7721	7721	C	T	MI.5475	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	136	46	L	F	Ctc/Ttc	-0.17	0	0	probably_damaging	1	neutral	0.39	neutral	1.29	neutral	-2.11	deleterious	-2.61	low_impact	1.07	0.55	damaging	0.17	damaging	2.42	18.92	deleterious	0.64	0.7	NA	NA	0.12	neutral	0.3	neutral	0.2	neutral	6	1	deleterious	0.2	neutral	-2	neutral	0.72	deleterious	-3.52	low_impact	0.1	medium_impact	-0.1	medium_impact	0.60	0.8	68.72	18.95	0.36	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7721	7721	C	A	MI.5476	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	136	46	L	I	Ctc/Atc	-0.17	0	0	probably_damaging	1	neutral	0.72	neutral	1.41	neutral	-0.92	neutral	-0.13	low_impact	0.87	0.69	neutral	0.54	neutral	2.38	18.67	deleterious	0.54	0.6	NA	NA	0.14	neutral	0.29	neutral	0.23	neutral	6	0.99	deleterious	0.36	neutral	-2	neutral	0.72	deleterious	-3.52	low_impact	0.43	medium_impact	-0.29	medium_impact	0.70	0.85	68.72	18.95	0.29	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7722	7722	T	A	MI.5477	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	137	46	L	H	cTc/cAc	-1.78	0	0	probably_damaging	1	neutral	0.06	neutral	1.21	deleterious	-4.57	deleterious	-4.92	high_impact	3.58	0.49	damaging	0.17	damaging	4.11	23.70	deleterious	0.34	0.5	NA	NA	0.58	disease	0.65	disease	0.67	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	-0.46	medium_impact	2.25	high_impact	0.65	0.8	68.72	18.95	0.36	N	0.94	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7722	7722	T	G	MI.5478	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	137	46	L	R	cTc/cGc	-1.78	0	0	probably_damaging	1	neutral	0.1	neutral	1.22	deleterious	-4.01	deleterious	-4.42	high_impact	3.58	0.3	damaging	0.13	damaging	4.03	23.70	deleterious	0.39	0.5	NA	NA	0.78	disease	0.67	disease	0.73	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.32	medium_impact	2.25	high_impact	0.57	0.8	68.72	18.95	0.5	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7722	7722	T	C	MI.5479	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	137	46	L	P	cTc/cCc	-1.78	0	0	probably_damaging	1	deleterious	0.02	neutral	1.21	deleterious	-4.6	deleterious	-4.76	medium_impact	3.23	0.3	damaging	0.09	damaging	3.81	23.40	deleterious	0.47	0.55	NA	NA	0.81	disease	0.69	disease	0.75	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.87	deleterious	-3.52	low_impact	-0.73	medium_impact	1.92	medium_impact	0.62	0.8	68.72	18.95	0.46	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8783	8783	G	T	MI.548	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	257	86	G	V	gGa/gTa	7.07	1	0	probably_damaging	1	deleterious	0	neutral	3.67	deleterious	-6.63	deleterious	-8.27	high_impact	4.58	0.55	damaging	0.09	damaging	3.68	23.30	deleterious	0.19	0.65	0.92	disease	0.84	disease	0.77	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.83	high_impact	0.56	0.9	50.44	8.61	0.55	P	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7724	7724	A	C	MI.5480	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	139	47	T	P	Aca/Cca	-2.01	0	0	possibly_damaging	0.75	neutral	0.12	neutral	1.49	neutral	-2.6	deleterious	-4.51	medium_impact	2.73	0.49	damaging	0.31	neutral	3.18	22.70	deleterious	0.43	0.55	NA	NA	0.82	disease	0.59	disease	0.7	disease	4	0.91	neutral	0.19	neutral	0	NA	0.77	deleterious	-1.17	low_impact	-0.27	medium_impact	1.45	medium_impact	0.80	0.85	66.52	17.39	0.35	N	0.90	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7724	7724	A	G	MI.5481	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	139	47	T	A	Aca/Gca	-2.01	0	0	benign	0.09	neutral	0.41	neutral	1.56	neutral	-0.36	deleterious	-3.67	medium_impact	2.47	0.69	neutral	0.67	neutral	1.39	12.74	neutral	0.71	0.75	NA	NA	0.3	neutral	0.39	neutral	0.16	neutral	7	0.53	neutral	0.66	deleterious	-3	neutral	0.19	neutral	0.22	medium_impact	0.12	medium_impact	1.21	medium_impact	0.59	0.8	66.52	17.39	0.43	N	0.65	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7724	7724	A	T	MI.5482	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	139	47	T	S	Aca/Tca	-2.01	0	0	benign	0.16	neutral	0.45	neutral	1.54	neutral	-0.79	neutral	-2.43	neutral_impact	0.4	0.78	neutral	0.81	neutral	-0.53	0.19	neutral	0.73	0.75	NA	NA	0.27	neutral	0.3	neutral	0.17	neutral	7	0.46	neutral	0.65	deleterious	-6	neutral	0.22	neutral	-0.05	medium_impact	0.16	medium_impact	-0.73	medium_impact	0.81	0.85	66.52	17.39	0.3	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7725	7725	C	T	MI.5483	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	140	47	T	M	aCa/aTa	1.44	0.02	0	benign	0.13	neutral	0.38	neutral	1.56	neutral	-0.36	deleterious	-4.54	low_impact	1.42	0.79	neutral	0.74	neutral	0.95	10.36	neutral	0.6	0.65	NA	NA	0.41	neutral	0.34	neutral	0.14	neutral	7	0.56	neutral	0.63	deleterious	-6	neutral	0.21	neutral	0.05	medium_impact	0.09	medium_impact	0.23	medium_impact	0.71	0.85	66.52	17.39	0.37	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7725	7725	C	A	MI.5484	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	140	47	T	K	aCa/aAa	1.44	0.02	0	benign	0.27	neutral	0.17	neutral	1.52	neutral	-1.06	deleterious	-4.56	low_impact	1.28	0.62	neutral	0.36	neutral	2.57	19.94	deleterious	0.52	0.6	NA	NA	0.67	disease	0.56	disease	0.27	neutral	5	0.8	neutral	0.45	neutral	-6	neutral	0.54	deleterious	-0.32	medium_impact	-0.18	medium_impact	0.1	medium_impact	0.61	0.8	66.52	17.39	0.34	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7727	7727	A	C	MI.5485	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	142	48	T	P	Aca/Cca	-4.09	0	0	probably_damaging	1	neutral	0.27	neutral	1.49	neutral	-2.12	deleterious	-4.69	medium_impact	2.78	0.33	damaging	0.1	damaging	3.31	22.90	deleterious	0.4	0.5	NA	NA	0.88	disease	0.68	disease	0.75	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.87	deleterious	-3.52	low_impact	-0.03	medium_impact	1.5	medium_impact	0.59	0.8	67.84	19.05	0.44	N	0.90	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7727	7727	A	T	MI.5486	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	142	48	T	S	Aca/Tca	-4.09	0	0	probably_damaging	0.99	neutral	0.79	neutral	1.6	neutral	0.18	deleterious	-2.63	low_impact	1.2	0.55	damaging	0.15	damaging	2.05	16.55	deleterious	0.71	0.75	NA	NA	0.52	disease	0.32	neutral	0.2	neutral	6	0.98	deleterious	0.4	neutral	-2	neutral	0.75	deleterious	-2.58	low_impact	0.52	medium_impact	0.02	medium_impact	0.78	0.85	67.84	19.05	0.24	N	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7727	7727	A	G	MI.5487	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	142	48	T	A	Aca/Gca	-4.09	0	0	probably_damaging	0.99	neutral	0.76	neutral	1.56	neutral	-0.36	deleterious	-3.24	medium_impact	2.08	0.65	neutral	0.41	neutral	2.21	17.61	deleterious	0.73	0.75	NA	NA	0.41	neutral	0.42	neutral	0.14	neutral	7	0.98	deleterious	0.39	neutral	1	deleterious	0.72	deleterious	-2.58	low_impact	0.48	medium_impact	0.85	medium_impact	0.64	0.8	67.84	19.05	0.24	N	0.65	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7728	7728	C	T	MI.5488	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	143	48	T	M	aCa/aTa	3.98	0.99	0	probably_damaging	1	neutral	0.15	neutral	1.49	neutral	-2.62	deleterious	-4.66	medium_impact	2.15	0.49	damaging	0.08	damaging	3.82	23.40	deleterious	0.64	0.7	NA	NA	0.68	disease	0.47	neutral	0.39	neutral	2	1	deleterious	0.08	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	-0.21	medium_impact	0.91	medium_impact	0.70	0.85	67.84	19.05	0.42	N	0.92	polymorphism	0.57	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7728	7728	C	A	MI.5489	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	143	48	T	K	aCa/aAa	3.98	0.99	0	probably_damaging	1	neutral	0.89	neutral	1.59	neutral	0.09	deleterious	-4.53	low_impact	1.84	0.42	damaging	0.03	damaging	4.36	24.10	deleterious	0.52	0.6	NA	NA	0.81	disease	0.41	neutral	0.63	disease	3	1	deleterious	0.45	neutral	-2	neutral	0.83	deleterious	-3.52	low_impact	0.71	medium_impact	0.62	medium_impact	0.79	0.85	67.84	19.05	0.48	N	0.94	disease_causing	0.58	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8783	8783	G	A	MI.549	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	257	86	G	E	gGa/gAa	7.07	1	0	probably_damaging	1	deleterious	0	neutral	3.73	deleterious	-5.88	deleterious	-7.34	high_impact	4.58	0.61	neutral	0.08	damaging	3.77	23.40	deleterious	0.27	0.65	0.87	disease	0.86	disease	0.83	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.83	high_impact	0.74	0.9	50.44	8.61	0.59	P	1.00	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7730	7730	A	C	MI.5490	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	145	49	K	Q	Aaa/Caa	-2.94	0	0	benign	0.13	neutral	0.28	neutral	1.41	neutral	-2.28	neutral	-2.49	medium_impact	2.84	0.57	damaging	0.48	neutral	1.44	13.02	neutral	0.65	0.7	NA	NA	0.74	disease	0.4	neutral	0.16	neutral	7	0.68	neutral	0.58	deleterious	-3	neutral	0.25	neutral	0.05	medium_impact	-0.02	medium_impact	1.56	medium_impact	0.75	0.85	67.4	17.16	0.42	N	0.90	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7730	7730	A	G	MI.5491	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	145	49	K	E	Aaa/Gaa	-2.94	0	0	benign	0.08	neutral	0.26	neutral	1.41	neutral	-1.63	deleterious	-2.54	medium_impact	2.84	0.58	damaging	0.75	neutral	1.99	16.16	deleterious	0.53	0.6	NA	NA	0.83	disease	0.67	disease	0.55	disease	1	0.71	neutral	0.59	deleterious	-3	neutral	0.28	neutral	0.27	medium_impact	-0.05	medium_impact	1.56	medium_impact	0.71	0.85	67.4	17.16	0.38	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7731	7731	A	T	MI.5492	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	146	49	K	M	aAa/aTa	6.98	1	0	possibly_damaging	0.66	neutral	0.2	neutral	1.39	deleterious	-4.59	deleterious	-4.1	medium_impact	3.42	0.52	damaging	0.45	neutral	3.43	23.00	deleterious	0.37	0.5	NA	NA	0.73	disease	0.56	disease	0.51	disease	0	0.82	neutral	0.27	neutral	0	NA	0.42	neutral	-0.99	medium_impact	-0.13	medium_impact	2.1	high_impact	0.51	0.8	67.4	17.16	0.58	P	0.75	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7731	7731	A	C	MI.5493	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	146	49	K	T	aAa/aCa	6.98	1	0	benign	0.01	neutral	0.45	neutral	1.44	neutral	-2.66	deleterious	-3.57	medium_impact	2.64	0.62	neutral	0.67	neutral	0.42	6.80	deleterious	0.43	0.55	NA	NA	0.66	disease	0.4	neutral	0.16	neutral	7	0.54	neutral	0.72	deleterious	-3	neutral	0.18	neutral	1.14	medium_impact	0.16	medium_impact	1.37	medium_impact	0.51	0.8	67.4	17.16	0.58	P	0.88	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7732	7732	A	T	MI.5494	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	147	49	K	N	aaA/aaT	3.75	0.99	0	benign	0.22	neutral	0.33	neutral	1.44	neutral	-2.28	deleterious	-2.71	medium_impact	2.2	0.64	neutral	0.67	neutral	0.86	9.80	deleterious	0.85	0.9	NA	NA	0.65	disease	0.42	neutral	0.16	neutral	7	0.6	neutral	0.56	deleterious	-3	neutral	0.37	neutral	-0.21	medium_impact	0.04	medium_impact	0.96	medium_impact	0.68	0.85	67.4	17.16	0.49	N	0.84	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7732	7732	A	C	MI.5495	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	147	49	K	N	aaA/aaC	3.75	0.99	0	benign	0.22	neutral	0.33	neutral	1.44	neutral	-2.28	deleterious	-2.71	medium_impact	2.2	0.64	neutral	0.67	neutral	0.81	9.50	deleterious	0.85	0.9	NA	NA	0.65	disease	0.42	neutral	0.16	neutral	7	0.6	neutral	0.56	deleterious	-3	neutral	0.37	neutral	-0.21	medium_impact	0.04	medium_impact	0.96	medium_impact	0.68	0.85	67.4	17.16	0.49	N	0.84	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7733	7733	C	A	MI.5496	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	148	50	L	M	Cta/Ata	0.06	0	0	benign	0.38	deleterious	0.04	neutral	1.37	neutral	-2.27	neutral	-1.59	medium_impact	2.51	0.6	damaging	0.49	neutral	3.39	23.00	deleterious	0.53	0.6	NA	NA	0.34	neutral	0.28	neutral	0.19	neutral	6	0.95	neutral	0.33	neutral	1	deleterious	0.29	neutral	-0.52	medium_impact	-0.56	medium_impact	1.25	medium_impact	0.78	0.85	68.72	18.99	0.48	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7733	7733	C	G	MI.5497	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	148	50	L	V	Cta/Gta	0.06	0	0	benign	0.38	neutral	0.24	neutral	1.47	neutral	-0.8	neutral	-2.49	medium_impact	2.25	0.51	damaging	0.49	neutral	2.87	21.70	deleterious	0.47	0.55	NA	NA	0.31	neutral	0.43	neutral	0.17	neutral	7	0.72	neutral	0.43	neutral	-3	neutral	0.35	neutral	-0.52	medium_impact	-0.07	medium_impact	1	medium_impact	0.70	0.85	68.72	18.99	0.46	N	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7734	7734	T	G	MI.5498	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	149	50	L	R	cTa/cGa	-0.86	0	0	probably_damaging	0.99	neutral	0.1	neutral	1.34	deleterious	-3.12	deleterious	-5.43	medium_impact	2.28	0.37	damaging	0.26	damaging	4.09	23.70	deleterious	0.47	0.55	NA	NA	0.81	disease	0.53	disease	0.64	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.85	deleterious	-2.58	low_impact	-0.32	medium_impact	1.03	medium_impact	0.49	0.8	68.72	18.99	0.49	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7734	7734	T	A	MI.5499	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	149	50	L	Q	cTa/cAa	-0.86	0	0	probably_damaging	0.99	neutral	0.12	neutral	1.39	neutral	-1.8	deleterious	-5.37	medium_impact	2.56	0.57	damaging	0.32	neutral	4.08	23.70	deleterious	0.42	0.55	NA	NA	0.63	disease	0.31	neutral	0.18	neutral	6	1	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-2.58	low_impact	-0.27	medium_impact	1.3	medium_impact	0.61	0.8	68.72	18.99	0.35	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8551	8551	T	A	MI.55	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	25	9	F	I	Ttc/Atc	0.59	0.99	0	probably_damaging	0.95	deleterious	0.01	neutral	3.88	neutral	-1.47	deleterious	-5.27	medium_impact	3.24	0.66	neutral	0.69	neutral	4.17	23.80	deleterious	0.29	0.65	0.66	disease	0.82	disease	0.81	disease	0.81	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.80	deleterious	-1.97	low_impact	-0.84	medium_impact	1.68	medium_impact	0.46	0.9	49.56	8.77	0.49	N	0.95	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8783	8783	G	C	MI.550	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	257	86	G	A	gGa/gCa	7.07	1	0	probably_damaging	1	deleterious	0	neutral	3.71	deleterious	-4.2	deleterious	-5.47	high_impact	4.03	0.66	neutral	0.11	damaging	3.05	22.40	deleterious	0.35	0.65	0.84	disease	0.62	disease	0.72	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.36	high_impact	0.75	0.9	50.44	8.61	0.51	N	0.79	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7734	7734	T	C	MI.5500	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	149	50	L	P	cTa/cCa	-0.86	0	0	probably_damaging	1	neutral	0.06	neutral	1.32	deleterious	-3.89	deleterious	-6.33	medium_impact	2.28	0.35	damaging	0.28	damaging	3.87	23.50	deleterious	0.51	0.6	NA	NA	0.83	disease	0.54	disease	0.69	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.87	deleterious	-3.52	low_impact	-0.46	medium_impact	1.03	medium_impact	0.52	0.8	68.72	18.99	0.5	N	0.99	polymorphism	0.93	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7736	7736	A	G	MI.5501	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	151	51	T	A	Act/Gct	-2.24	0	0	benign	0.28	neutral	0.4	neutral	1.53	neutral	0.15	deleterious	-3.58	medium_impact	2.02	0.52	damaging	0.52	neutral	1.72	14.51	neutral	0.76	0.8	NA	NA	0.35	neutral	0.44	neutral	0.17	neutral	7	0.52	neutral	0.56	deleterious	-3	neutral	0.46	deleterious	-0.34	medium_impact	0.11	medium_impact	0.79	medium_impact	0.33	0.8	67.4	17.12	0.41	N	0.65	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7736	7736	A	C	MI.5502	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	151	51	T	P	Act/Cct	-2.24	0	0	probably_damaging	0.95	neutral	0.16	neutral	1.47	neutral	-1.25	deleterious	-4.71	medium_impact	2.39	0.42	damaging	0.3	neutral	3.33	22.90	deleterious	0.52	0.6	NA	NA	0.79	disease	0.43	neutral	0.43	neutral	1	0.97	neutral	0.11	neutral	1	deleterious	0.82	deleterious	-1.91	low_impact	-0.19	medium_impact	1.14	medium_impact	0.52	0.8	67.4	17.12	0.42	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7736	7736	A	T	MI.5503	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	151	51	T	S	Act/Tct	-2.24	0	0	possibly_damaging	0.5	neutral	0.58	neutral	1.53	neutral	0.21	neutral	-2.45	low_impact	1.76	0.66	neutral	0.75	neutral	1.57	13.68	neutral	0.74	0.75	NA	NA	0.34	neutral	0.25	neutral	0.19	neutral	6	0.45	neutral	0.54	deleterious	-3	neutral	0.52	deleterious	-0.72	medium_impact	0.28	medium_impact	0.55	medium_impact	0.54	0.8	67.4	17.12	0.31	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7737	7737	C	T	MI.5504	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	152	51	T	I	aCt/aTt	4.44	0.9	0	benign	0.35	neutral	0.47	neutral	1.49	neutral	-1.45	deleterious	-4.43	neutral_impact	0.72	0.75	neutral	0.84	neutral	0.96	10.41	neutral	0.79	0.8	NA	NA	0.23	neutral	0.28	neutral	0.19	neutral	6	0.45	neutral	0.56	deleterious	-6	neutral	0.30	neutral	-0.47	medium_impact	0.18	medium_impact	-0.43	medium_impact	0.46	0.8	67.4	17.12	0.43	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7737	7737	C	G	MI.5505	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	152	51	T	S	aCt/aGt	4.44	0.9	0	possibly_damaging	0.5	neutral	0.58	neutral	1.53	neutral	0.21	neutral	-2.45	low_impact	1.76	0.66	neutral	0.75	neutral	1.70	14.42	neutral	0.74	0.75	NA	NA	0.34	neutral	0.25	neutral	0.19	neutral	6	0.45	neutral	0.54	deleterious	-3	neutral	0.52	deleterious	-0.72	medium_impact	0.28	medium_impact	0.55	medium_impact	0.54	0.8	67.4	17.12	0.36	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7737	7737	C	A	MI.5506	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	152	51	T	N	aCt/aAt	4.44	0.9	0	probably_damaging	0.92	neutral	0.3	neutral	1.44	neutral	-0.13	deleterious	-3.67	medium_impact	1.94	0.51	damaging	0.41	neutral	3.54	23.10	deleterious	0.9	0.95	NA	NA	0.6	disease	0.3	neutral	0.19	neutral	6	0.93	neutral	0.19	neutral	1	deleterious	0.75	deleterious	-1.71	low_impact	0	medium_impact	0.71	medium_impact	0.64	0.8	67.4	17.12	0.45	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7739	7739	A	T	MI.5507	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	154	52	N	Y	Aat/Tat	-11.47	0	0	possibly_damaging	0.9	neutral	1	neutral	1.43	neutral	-2.07	deleterious	-2.85	low_impact	1.65	0.7	neutral	0.75	neutral	2.43	19.05	deleterious	0.66	0.7	NA	NA	0.72	disease	0.46	neutral	0.5	neutral	0	0.89	neutral	0.55	deleterious	-3	neutral	0.76	deleterious	-1.61	low_impact	1.86	high_impact	0.44	medium_impact	0.43	0.8	27.75	67.09	0.24	N	0.44	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7739	7739	A	G	MI.5508	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	154	52	N	D	Aat/Gat	-11.47	0	0	benign	0.34	neutral	0.2	neutral	1.5	neutral	-0.85	neutral	-1.92	neutral_impact	0.52	0.72	neutral	0.81	neutral	0.61	8.23	deleterious	0.92	0.95	NA	NA	0.4	neutral	0.36	neutral	0.17	neutral	7	0.76	neutral	0.43	neutral	-6	neutral	0.39	neutral	-0.45	medium_impact	-0.13	medium_impact	-0.62	medium_impact	0.52	0.8	27.75	67.09	0.45	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7739	7739	A	C	MI.5509	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	154	52	N	H	Aat/Cat	-11.47	0	0	possibly_damaging	0.9	neutral	0.58	neutral	1.48	neutral	-1.1	neutral	0.1	neutral_impact	0.47	0.74	neutral	0.93	neutral	1.29	12.21	neutral	0.89	0.9	NA	NA	0.44	neutral	0.39	neutral	0.2	neutral	6	0.88	neutral	0.34	neutral	-3	neutral	0.70	deleterious	-1.61	low_impact	0.28	medium_impact	-0.67	medium_impact	0.44	0.8	27.75	67.09	0.33	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8785	8785	C	A	MI.551	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	259	87	L	I	Ctc/Atc	-14.45	0	0	probably_damaging	0.99	deleterious	0.02	neutral	3.88	neutral	-2.93	neutral	-1.79	medium_impact	3.17	0.56	damaging	0.56	neutral	4.01	23.60	deleterious	0.41	0.65	0.56	disease	0.42	neutral	0.58	disease	0.56	disease	1	1	deleterious	0.02	neutral	5	deleterious	0.73	deleterious	-2.65	low_impact	-0.66	medium_impact	1.62	medium_impact	0.71	0.9	14.6	18.39	0.42	N	0.87	polymorphism	0.56	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7740	7740	A	G	MI.5510	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	155	52	N	S	aAt/aGt	0.29	0.05	0	benign	0.04	neutral	0.45	neutral	1.47	neutral	-1.17	neutral	-2.48	low_impact	1.26	0.8	neutral	0.94	neutral	-0.03	2.30	deleterious	0.85	0.85	NA	NA	0.59	disease	0.39	neutral	0.45	neutral	1	0.51	neutral	0.71	deleterious	-6	neutral	0.19	neutral	0.57	medium_impact	0.16	medium_impact	0.08	medium_impact	0.23	0.8	27.75	67.09	0.33	N	0.11	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7740	7740	A	C	MI.5511	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	155	52	N	T	aAt/aCt	0.29	0.05	0	benign	0.34	neutral	0.38	neutral	1.46	neutral	-1.3	deleterious	-3.54	medium_impact	2.28	0.56	damaging	0.61	neutral	1.67	14.25	neutral	0.8	0.85	NA	NA	0.66	disease	0.38	neutral	0.47	neutral	1	0.55	neutral	0.52	deleterious	-3	neutral	0.35	neutral	-0.45	medium_impact	0.09	medium_impact	1.03	medium_impact	0.40	0.8	27.75	67.09	0.39	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7740	7740	A	T	MI.5512	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	155	52	N	I	aAt/aTt	0.29	0.05	0	possibly_damaging	0.86	neutral	0.39	neutral	1.4	deleterious	-3.12	deleterious	-5.38	medium_impact	2.93	0.54	damaging	0.61	neutral	3.72	23.30	deleterious	0.65	0.7	NA	NA	0.79	disease	0.61	disease	0.67	disease	3	0.86	neutral	0.27	neutral	0	NA	0.70	deleterious	-1.46	low_impact	0.1	medium_impact	1.64	medium_impact	0.32	0.8	27.75	67.09	0.35	N	0.88	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7741	7741	T	A	MI.5513	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	156	52	N	K	aaT/aaA	4.21	0.43	0	possibly_damaging	0.46	neutral	0.29	neutral	1.53	neutral	-0.45	deleterious	-3.27	medium_impact	2.79	0.5	damaging	0.51	neutral	2.56	19.84	deleterious	0.89	0.9	NA	NA	0.77	disease	0.64	disease	0.67	disease	3	0.67	neutral	0.42	neutral	0	NA	0.49	deleterious	-0.66	medium_impact	-0.01	medium_impact	1.51	medium_impact	0.46	0.8	27.75	67.09	0.42	N	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7741	7741	T	G	MI.5514	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	156	52	N	K	aaT/aaG	4.21	0.43	0	possibly_damaging	0.46	neutral	0.29	neutral	1.53	neutral	-0.45	deleterious	-3.27	medium_impact	2.79	0.5	damaging	0.51	neutral	2.26	17.93	deleterious	0.89	0.9	NA	NA	0.77	disease	0.64	disease	0.67	disease	3	0.67	neutral	0.42	neutral	0	NA	0.49	deleterious	-0.66	medium_impact	-0.01	medium_impact	1.51	medium_impact	0.46	0.8	27.75	67.09	0.4	N	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7742	7742	A	T	MI.5515	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	157	53	T	S	Act/Tct	-5.7	0	0	probably_damaging	0.99	neutral	0.45	neutral	1.63	neutral	0.57	neutral	-2.12	low_impact	0.9	0.71	neutral	0.58	neutral	1.20	11.72	neutral	0.75	0.8	NA	NA	0.37	neutral	0.55	disease	0.31	neutral	4	0.99	deleterious	0.23	neutral	-2	neutral	0.75	deleterious	-2.58	low_impact	0.16	medium_impact	-0.26	medium_impact	0.59	0.8	66.52	19.11	0.28	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7742	7742	A	G	MI.5516	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	157	53	T	A	Act/Gct	-5.7	0	0	probably_damaging	0.99	neutral	0.53	neutral	1.58	neutral	-0.03	deleterious	-3	low_impact	1.42	0.62	neutral	0.38	neutral	0.16	4.28	deleterious	0.68	0.7	NA	NA	0.28	neutral	0.59	disease	0.35	neutral	3	0.99	deleterious	0.27	neutral	-2	neutral	0.72	deleterious	-2.58	low_impact	0.23	medium_impact	0.23	medium_impact	0.28	0.8	66.52	19.11	0.25	N	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7742	7742	A	C	MI.5517	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	157	53	T	P	Act/Cct	-5.7	0	0	probably_damaging	1	neutral	0.22	neutral	1.52	neutral	-1.78	deleterious	-3.82	low_impact	1.07	0.41	damaging	0.13	damaging	2.05	16.53	deleterious	0.41	0.5	NA	NA	0.78	disease	0.56	disease	0.69	disease	4	1	deleterious	0.11	neutral	-2	neutral	0.83	deleterious	-3.52	low_impact	-0.1	medium_impact	-0.1	medium_impact	0.57	0.8	66.52	19.11	0.41	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7743	7743	C	T	MI.5518	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	158	53	T	I	aCt/aTt	4.67	1	0	probably_damaging	1	neutral	0.43	neutral	1.52	neutral	-1.69	deleterious	-3.89	low_impact	1.36	0.52	damaging	0.17	damaging	0.70	8.84	deleterious	0.51	0.6	NA	NA	0.48	neutral	0.57	disease	0.49	neutral	0	1	deleterious	0.22	neutral	-2	neutral	0.79	deleterious	-3.52	low_impact	0.14	medium_impact	0.17	medium_impact	0.45	0.8	66.52	19.11	0.47	N	0.77	disease_causing	0.8	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7743	7743	C	A	MI.5519	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	158	53	T	N	aCt/aAt	4.67	1	0	probably_damaging	1	neutral	0.37	neutral	1.56	neutral	-0.45	deleterious	-2.71	low_impact	1.32	0.56	damaging	0.26	damaging	2.19	17.47	deleterious	0.7	0.75	NA	NA	0.62	disease	0.46	neutral	0.38	neutral	2	1	deleterious	0.19	neutral	-2	neutral	0.78	deleterious	-3.52	low_impact	0.08	medium_impact	0.13	medium_impact	0.56	0.8	66.52	19.11	0.43	N	0.87	disease_causing	0.79	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8785	8785	C	T	MI.552	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	259	87	L	F	Ctc/Ttc	-14.45	0	0	probably_damaging	1	deleterious	0	neutral	3.83	deleterious	-3.93	deleterious	-3.59	high_impact	3.94	0.35	damaging	0.43	neutral	3.95	23.60	deleterious	0.41	0.65	0.74	disease	0.6	disease	0.69	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.79	deleterious	-3.6	low_impact	-1.4	low_impact	2.28	high_impact	0.66	0.9	14.6	18.39	0.54	P	0.97	disease_causing	0.88	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7743	7743	C	G	MI.5520	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	158	53	T	S	aCt/aGt	4.67	1	0	probably_damaging	0.99	neutral	0.45	neutral	1.63	neutral	0.57	neutral	-2.12	low_impact	0.9	0.71	neutral	0.58	neutral	1.56	13.63	neutral	0.75	0.8	NA	NA	0.37	neutral	0.55	disease	0.31	neutral	4	0.99	deleterious	0.23	neutral	-2	neutral	0.75	deleterious	-2.58	low_impact	0.16	medium_impact	-0.26	medium_impact	0.59	0.8	66.52	19.11	0.45	N	0.80	polymorphism	0.73	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7745	7745	A	C	MI.5521	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	160	54	N	H	Aac/Cac	-5.7	0	0	possibly_damaging	0.72	neutral	0.48	neutral	1.53	neutral	-1.23	neutral	-1.27	low_impact	1.02	0.79	neutral	0.74	neutral	0.80	9.49	deleterious	0.73	0.75	NA	NA	0.24	neutral	0.32	neutral	0.15	neutral	7	0.71	neutral	0.38	neutral	-3	neutral	0.54	deleterious	-1.1	low_impact	0.19	medium_impact	-0.15	medium_impact	0.37	0.8	29.52	35.15	0.3	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7745	7745	A	G	MI.5522	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	160	54	N	D	Aac/Gac	-5.7	0	0	benign	0.14	neutral	0.23	neutral	1.55	neutral	-0.9	neutral	-1.86	medium_impact	2.02	0.68	neutral	0.48	neutral	0.62	8.27	deleterious	0.85	0.9	NA	NA	0.34	neutral	0.45	neutral	0.15	neutral	7	0.73	neutral	0.55	deleterious	-3	neutral	0.19	neutral	0.01	medium_impact	-0.09	medium_impact	0.79	medium_impact	0.53	0.8	29.52	35.15	0.43	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7745	7745	A	T	MI.5523	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	160	54	N	Y	Aac/Tac	-5.7	0	0	possibly_damaging	0.72	neutral	1	neutral	1.7	neutral	-1.31	neutral	-2.29	neutral_impact	-0.04	0.74	neutral	0.86	neutral	0.56	7.88	deleterious	0.47	0.55	NA	NA	0.17	neutral	0.26	neutral	0.17	neutral	7	0.72	neutral	0.64	deleterious	-3	neutral	0.54	deleterious	-1.1	low_impact	1.86	high_impact	-1.14	low_impact	0.37	0.8	29.52	35.15	0.24	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7746	7746	A	C	MI.5524	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	161	54	N	T	aAc/aCc	2.6	0.02	0	benign	0.14	neutral	0.43	neutral	1.59	neutral	-0.68	neutral	-1.85	low_impact	1.24	0.79	neutral	0.83	neutral	-0.17	1.28	neutral	0.61	0.65	NA	NA	0.27	neutral	0.26	neutral	0.18	neutral	6	0.49	neutral	0.65	deleterious	-6	neutral	0.16	neutral	0.01	medium_impact	0.14	medium_impact	0.06	medium_impact	0.32	0.8	29.52	35.15	0.4	N	0.14	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7746	7746	A	T	MI.5525	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	161	54	N	I	aAc/aTc	2.6	0.02	0	possibly_damaging	0.66	neutral	0.47	neutral	1.57	neutral	-2.64	deleterious	-3.53	medium_impact	2.11	0.68	neutral	0.55	neutral	0.59	8.11	deleterious	0.46	0.55	NA	NA	0.4	neutral	0.43	neutral	0.15	neutral	7	0.64	neutral	0.41	neutral	0	NA	0.48	deleterious	-0.99	medium_impact	0.18	medium_impact	0.87	medium_impact	0.29	0.8	29.52	35.15	0.4	N	0.38	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7746	7746	A	G	MI.5526	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	161	54	N	S	aAc/aGc	2.6	0.02	0	benign	0.01	neutral	0.44	neutral	1.59	neutral	-0.49	neutral	-0.95	neutral_impact	0.16	0.87	neutral	0.99	neutral	-0.67	0.08	neutral	0.74	0.75	NA	NA	0.23	neutral	0.3	neutral	0.17	neutral	7	0.55	neutral	0.72	deleterious	-6	neutral	0.11	neutral	1.14	medium_impact	0.15	medium_impact	-0.96	medium_impact	0.14	0.8	29.52	35.15	0.43	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7747	7747	C	A	MI.5527	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	162	54	N	K	aaC/aaA	-0.4	0	0	benign	0.2	neutral	0.32	neutral	1.62	neutral	-0.11	neutral	-2.27	neutral_impact	0.7	0.7	neutral	0.47	neutral	1.01	10.73	neutral	0.79	0.8	NA	NA	0.39	neutral	0.48	neutral	0.15	neutral	7	0.62	neutral	0.56	deleterious	-6	neutral	0.26	neutral	-0.16	medium_impact	0.02	medium_impact	-0.45	medium_impact	0.43	0.8	29.52	35.15	0.36	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7747	7747	C	G	MI.5528	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	162	54	N	K	aaC/aaG	-0.4	0	0	benign	0.2	neutral	0.32	neutral	1.62	neutral	-0.11	neutral	-2.27	neutral_impact	0.7	0.7	neutral	0.47	neutral	0.48	7.31	deleterious	0.79	0.8	NA	NA	0.39	neutral	0.48	neutral	0.15	neutral	7	0.62	neutral	0.56	deleterious	-6	neutral	0.26	neutral	-0.16	medium_impact	0.02	medium_impact	-0.45	medium_impact	0.43	0.8	29.52	35.15	0.36	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7748	7748	A	G	MI.5529	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	163	55	I	V	Atc/Gtc	-2.01	0	0	probably_damaging	0.97	neutral	0.38	neutral	1.55	neutral	-0.04	neutral	0.51	neutral_impact	0.05	0.78	neutral	0.86	neutral	-0.39	0.42	neutral	0.69	0.75	NA	NA	0.13	neutral	0.36	neutral	0.23	neutral	5	0.97	neutral	0.21	neutral	-2	neutral	0.62	deleterious	-2.13	low_impact	0.09	medium_impact	-1.06	low_impact	0.44	0.8	28.63	65.2	0.38	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8785	8785	C	G	MI.553	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	259	87	L	V	Ctc/Gtc	-14.45	0	0	probably_damaging	0.99	deleterious	0.01	neutral	3.92	neutral	-2.38	deleterious	-2.66	high_impact	3.94	0.36	damaging	0.42	neutral	3.35	22.90	deleterious	0.47	0.65	0.59	disease	0.45	neutral	0.68	disease	0.58	disease	2	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-2.65	low_impact	-0.84	medium_impact	2.28	high_impact	0.74	0.9	14.6	18.39	0.56	P	0.87	disease_causing	0.58	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7748	7748	A	C	MI.5530	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	163	55	I	L	Atc/Ctc	-2.01	0	0	probably_damaging	0.97	neutral	1	neutral	1.7	neutral	-0.5	neutral	-0.26	neutral_impact	-0.2	0.68	neutral	0.64	neutral	-0.65	0.10	neutral	0.55	0.6	NA	NA	0.09	neutral	0.21	neutral	0.21	neutral	6	0.97	neutral	0.52	deleterious	-2	neutral	0.61	deleterious	-2.13	low_impact	1.86	high_impact	-1.29	low_impact	0.63	0.8	28.63	65.2	0.29	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7748	7748	A	T	MI.5531	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	163	55	I	F	Atc/Ttc	-2.01	0	0	probably_damaging	0.99	neutral	0.33	neutral	1.58	neutral	-0.04	neutral	-1.62	neutral_impact	0.36	0.58	damaging	0.43	neutral	2.02	16.32	deleterious	0.49	0.55	NA	NA	0.47	neutral	0.34	neutral	0.23	neutral	5	0.99	deleterious	0.17	neutral	-2	neutral	0.71	deleterious	-2.58	low_impact	0.04	medium_impact	-0.77	medium_impact	0.67	0.85	28.63	65.2	0.36	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7749	7749	T	A	MI.5532	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	164	55	I	N	aTc/aAc	4.44	0.94	0	probably_damaging	1	neutral	0.1	neutral	1.46	deleterious	-3.25	neutral	-1.15	low_impact	1.5	0.6	damaging	0.45	neutral	2.64	20.40	deleterious	0.46	0.55	NA	NA	0.65	disease	0.6	disease	0.69	disease	4	1	deleterious	0.05	neutral	-2	neutral	0.76	deleterious	-3.52	low_impact	-0.32	medium_impact	0.3	medium_impact	0.59	0.8	28.63	65.2	0.44	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7749	7749	T	G	MI.5533	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	164	55	I	S	aTc/aGc	4.44	0.94	0	probably_damaging	0.99	neutral	0.34	neutral	1.49	neutral	-1.96	neutral	0.07	low_impact	1.21	0.67	neutral	0.64	neutral	1.16	11.52	neutral	0.4	0.5	NA	NA	0.59	disease	0.4	neutral	0.33	neutral	3	0.99	deleterious	0.18	neutral	-2	neutral	0.74	deleterious	-2.58	low_impact	0.05	medium_impact	0.03	medium_impact	0.63	0.8	28.63	65.2	0.44	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7749	7749	T	C	MI.5534	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	164	55	I	T	aTc/aCc	4.44	0.94	0	probably_damaging	0.99	neutral	0.24	neutral	1.52	neutral	-0.8	neutral	2.38	neutral_impact	-0.26	0.78	neutral	0.91	neutral	-1.36	0.00	neutral	0.58	0.65	NA	NA	0.24	neutral	0.35	neutral	0.14	neutral	7	1	deleterious	0.13	neutral	-2	neutral	0.69	deleterious	-2.58	low_impact	-0.07	medium_impact	-1.35	low_impact	0.65	0.8	28.63	65.2	0.43	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7750	7750	C	G	MI.5535	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	165	55	I	M	atC/atG	2.14	0.91	0	probably_damaging	1	neutral	0.25	neutral	1.5	neutral	-1.91	neutral	-0.29	neutral_impact	0.22	0.67	neutral	0.61	neutral	1.93	15.77	deleterious	0.62	0.65	NA	NA	0.22	neutral	0.27	neutral	0.16	neutral	7	1	deleterious	0.13	neutral	-2	neutral	0.68	deleterious	-3.52	low_impact	-0.06	medium_impact	-0.9	medium_impact	0.70	0.85	28.63	65.2	0.43	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7750	7750	C	A	MI.5536	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	165	55	I	M	atC/atA	2.14	0.91	0	probably_damaging	1	neutral	0.25	neutral	1.5	neutral	-1.91	neutral	-0.29	neutral_impact	0.22	0.67	neutral	0.61	neutral	2.35	18.47	deleterious	0.62	0.65	NA	NA	0.22	neutral	0.27	neutral	0.16	neutral	7	1	deleterious	0.13	neutral	-2	neutral	0.68	deleterious	-3.52	low_impact	-0.06	medium_impact	-0.9	medium_impact	0.70	0.85	28.63	65.2	0.43	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7751	7751	T	G	MI.5537	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	166	56	S	A	Tca/Gca	-12.16	0	0	benign	0.03	neutral	0.49	neutral	1.61	neutral	-0.63	neutral	0.37	low_impact	1.21	0.77	neutral	0.71	neutral	1.65	14.15	neutral	0.63	0.7	NA	NA	0.16	neutral	0.54	disease	0.22	neutral	6	0.48	neutral	0.73	deleterious	-6	neutral	0.13	neutral	0.69	medium_impact	0.2	medium_impact	0.03	medium_impact	0.54	0.8	29.52	67.06	0.37	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7751	7751	T	C	MI.5538	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	166	56	S	P	Tca/Cca	-12.16	0	0	benign	0.2	neutral	0.18	neutral	1.54	neutral	-1.32	neutral	-1.2	medium_impact	2.02	0.69	neutral	0.38	neutral	2.12	16.96	deleterious	0.41	0.5	NA	NA	0.66	disease	0.53	disease	0.58	disease	2	0.79	neutral	0.49	deleterious	-3	neutral	0.32	neutral	-0.16	medium_impact	-0.16	medium_impact	0.79	medium_impact	0.50	0.8	29.52	67.06	0.35	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7751	7751	T	A	MI.5539	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	166	56	S	T	Tca/Aca	-12.16	0	0	benign	0	neutral	0.48	neutral	1.65	neutral	-0.71	neutral	0.81	neutral_impact	-0.42	0.92	neutral	0.84	neutral	0.38	6.43	deleterious	0.48	0.55	NA	NA	0.16	neutral	0.27	neutral	0.22	neutral	6	0.52	neutral	0.74	deleterious	-6	neutral	0.11	neutral	2.08	high_impact	0.19	medium_impact	-1.5	low_impact	0.59	0.8	29.52	67.06	0.41	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8786	8786	T	A	MI.554	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	260	87	L	H	cTc/cAc	0.13	0	0	probably_damaging	1	deleterious	0	neutral	3.8	deleterious	-5.48	deleterious	-6.31	high_impact	4.49	0.43	damaging	0.37	neutral	4.26	23.90	deleterious	0.22	0.65	0.92	disease	0.75	disease	0.76	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.75	high_impact	0.61	0.9	14.6	18.39	0.6	P	0.97	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7752	7752	C	G	MI.5540	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	167	56	S	W	tCa/tGa	0.52	0.06	0	possibly_damaging	0.74	neutral	0.24	neutral	1.53	deleterious	-5.48	neutral	-0.84	medium_impact	2.02	0.62	neutral	0.44	neutral	4.07	23.70	deleterious	0.27	0.45	NA	NA	0.59	disease	0.63	disease	0.65	disease	3	0.83	neutral	0.25	neutral	0	NA	0.64	deleterious	-1.14	low_impact	-0.07	medium_impact	0.79	medium_impact	0.51	0.8	29.52	67.06	0.41	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7752	7752	C	T	MI.5541	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	167	56	S	L	tCa/tTa	0.52	0.06	0	benign	0.07	neutral	1	neutral	1.81	neutral	-2.21	neutral	2.97	neutral_impact	-1.88	0.7	neutral	0.81	neutral	-0.02	2.39	deleterious	0.52	0.6	NA	NA	0.09	neutral	0.27	neutral	0.18	neutral	6	0.07	neutral	0.97	deleterious	-6	neutral	0.10	neutral	0.33	medium_impact	1.86	high_impact	-2.87	low_impact	0.84	0.9	29.52	67.06	0.29	N	0.30	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7754	7754	G	A	MI.5542	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	169	57	D	N	Gac/Aac	0.29	0.96	0	benign	0.01	neutral	0.45	neutral	1.53	neutral	-0.67	deleterious	-3.56	low_impact	1.43	0.71	neutral	0.71	neutral	1.03	10.85	neutral	0.85	0.9	NA	NA	0.54	disease	0.41	neutral	0.17	neutral	7	0.54	neutral	0.72	deleterious	-6	neutral	0.16	neutral	1.14	medium_impact	0.16	medium_impact	0.24	medium_impact	0.65	0.8	71.81	14.32	0.39	N	0.99	polymorphism	0.66	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7754	7754	G	T	MI.5543	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	169	57	D	Y	Gac/Tac	0.29	0.96	0	probably_damaging	0.91	neutral	0.05	neutral	1.44	deleterious	-3.26	deleterious	-7.82	medium_impact	3.21	0.48	damaging	0.25	damaging	3.75	23.30	deleterious	0.33	0.5	NA	NA	0.78	disease	0.67	disease	0.71	disease	4	0.98	deleterious	0.07	neutral	1	deleterious	0.76	deleterious	-1.66	low_impact	-0.5	medium_impact	1.9	medium_impact	0.23	0.8	71.81	14.32	0.42	N	0.99	disease_causing	0.85	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7754	7754	G	C	MI.5544	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	169	57	D	H	Gac/Cac	0.29	0.96	0	possibly_damaging	0.69	neutral	0.12	neutral	1.63	neutral	0.4	deleterious	-5.83	low_impact	0.96	0.55	damaging	0.22	damaging	2.20	17.52	deleterious	0.6	0.65	NA	NA	0.4	neutral	0.5	neutral	0.15	neutral	7	0.9	neutral	0.22	neutral	-3	neutral	0.58	deleterious	-1.04	low_impact	-0.27	medium_impact	-0.21	medium_impact	0.63	0.8	71.81	14.32	0.38	N	0.98	disease_causing	0.73	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7755	7755	A	C	MI.5545	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	170	57	D	A	gAc/gCc	3.52	1	0	benign	0.16	neutral	0.66	neutral	1.48	neutral	-1.45	deleterious	-6.96	medium_impact	2.66	0.64	neutral	0.39	neutral	1.68	14.30	neutral	0.34	0.5	NA	NA	0.58	disease	0.64	disease	0.67	disease	3	0.22	neutral	0.75	deleterious	-3	neutral	0.37	neutral	-0.05	medium_impact	0.36	medium_impact	1.39	medium_impact	0.36	0.8	71.81	14.32	0.4	N	0.96	disease_causing	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7755	7755	A	G	MI.5546	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	170	57	D	G	gAc/gGc	3.52	1	0	benign	0.21	neutral	0.32	neutral	1.6	neutral	0.16	deleterious	-6.01	medium_impact	2.58	0.57	damaging	0.36	neutral	2.10	16.83	deleterious	0.41	0.5	NA	NA	0.7	disease	0.64	disease	0.68	disease	4	0.62	neutral	0.56	deleterious	-3	neutral	0.27	neutral	-0.18	medium_impact	0.02	medium_impact	1.31	medium_impact	0.36	0.8	71.81	14.32	0.43	N	0.97	disease_causing	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7755	7755	A	T	MI.5547	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	170	57	D	V	gAc/gTc	3.52	1	0	possibly_damaging	0.61	neutral	0.25	neutral	1.44	deleterious	-3.64	deleterious	-7.92	medium_impact	2.87	0.51	damaging	0.26	damaging	3.27	22.80	deleterious	0.3	0.45	NA	NA	0.68	disease	0.63	disease	0.69	disease	4	0.76	neutral	0.32	neutral	0	NA	0.59	deleterious	-0.9	medium_impact	-0.06	medium_impact	1.59	medium_impact	0.29	0.8	71.81	14.32	0.44	N	0.99	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7756	7756	C	A	MI.5548	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	171	57	D	E	gaC/gaA	8.59	1	0	benign	0.04	neutral	1	neutral	1.71	neutral	0.89	deleterious	-3.31	neutral_impact	0.34	0.55	damaging	0.33	neutral	0.86	9.81	deleterious	0.72	0.75	NA	NA	0.16	neutral	0.26	neutral	0.16	neutral	7	0.04	neutral	0.98	deleterious	-6	neutral	0.13	neutral	0.57	medium_impact	1.86	high_impact	-0.79	medium_impact	0.54	0.8	71.81	14.32	0.51	P	0.95	disease_causing	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7756	7756	C	G	MI.5549	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	171	57	D	E	gaC/gaG	8.59	1	0	benign	0.04	neutral	1	neutral	1.71	neutral	0.89	deleterious	-3.31	neutral_impact	0.34	0.55	damaging	0.33	neutral	0.51	7.53	deleterious	0.72	0.75	NA	NA	0.16	neutral	0.26	neutral	0.16	neutral	7	0.04	neutral	0.98	deleterious	-6	neutral	0.13	neutral	0.57	medium_impact	1.86	high_impact	-0.79	medium_impact	0.54	0.8	71.81	14.32	0.52	P	0.95	disease_causing	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8786	8786	T	G	MI.555	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	260	87	L	R	cTc/cGc	0.13	0	0	probably_damaging	1	deleterious	0	neutral	3.81	deleterious	-4.87	deleterious	-5.39	high_impact	4.14	0.31	damaging	0.36	neutral	4.15	23.80	deleterious	0.16	0.65	0.89	disease	0.81	disease	0.79	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.45	high_impact	0.59	0.9	14.6	18.39	0.72	P	0.99	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7757	7757	G	T	MI.5550	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	172	58	A	S	Gct/Tct	-5.47	0	0	probably_damaging	0.99	neutral	0.78	neutral	1.7	neutral	0.7	neutral	-0.98	neutral_impact	0.24	0.7	neutral	0.77	neutral	1.40	12.78	neutral	0.49	0.55	NA	NA	0.34	neutral	0.28	neutral	0.16	neutral	7	0.99	deleterious	0.4	neutral	-2	neutral	0.76	deleterious	-2.58	low_impact	0.51	medium_impact	-0.88	medium_impact	0.69	0.85	68.28	18.75	0.28	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7757	7757	G	C	MI.5551	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	172	58	A	P	Gct/Cct	-5.47	0	0	probably_damaging	1	neutral	0.26	neutral	1.54	neutral	-1.92	deleterious	-3.86	medium_impact	3.13	0.51	damaging	0.27	damaging	3.76	23.40	deleterious	0.29	0.45	NA	NA	0.84	disease	0.57	disease	0.74	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.87	deleterious	-3.52	low_impact	-0.05	medium_impact	1.83	medium_impact	0.76	0.85	68.28	18.75	0.38	N	0.90	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7757	7757	G	A	MI.5552	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	172	58	A	T	Gct/Act	-5.47	0	0	probably_damaging	0.99	neutral	0.55	neutral	1.55	neutral	-0.95	neutral	-2.43	medium_impact	2.58	0.69	neutral	0.44	neutral	4.18	23.80	deleterious	0.61	0.65	NA	NA	0.51	disease	0.59	disease	0.66	disease	3	0.99	deleterious	0.28	neutral	1	deleterious	0.77	deleterious	-2.58	low_impact	0.25	medium_impact	1.31	medium_impact	0.84	0.9	68.28	18.75	0.26	N	0.72	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7758	7758	C	G	MI.5553	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	173	58	A	G	gCt/gGt	3.06	0.99	0	probably_damaging	0.98	neutral	0.43	neutral	1.73	neutral	-0.31	deleterious	-2.79	neutral_impact	0.2	0.58	damaging	0.52	neutral	2.22	17.64	deleterious	0.48	0.55	NA	NA	0.07	neutral	0.23	neutral	0.22	neutral	6	0.97	neutral	0.23	neutral	-2	neutral	0.68	deleterious	-2.3	low_impact	0.14	medium_impact	-0.92	medium_impact	0.71	0.85	68.28	18.75	0.48	P	0.74	disease_causing	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7758	7758	C	A	MI.5554	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	173	58	A	D	gCt/gAt	3.06	0.99	0	probably_damaging	1	neutral	0.59	neutral	1.58	neutral	-1.07	deleterious	-4.18	medium_impact	2.04	0.54	damaging	0.34	neutral	4.35	24.10	deleterious	0.28	0.45	NA	NA	0.78	disease	0.65	disease	0.72	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.29	medium_impact	0.81	medium_impact	0.64	0.8	68.28	18.75	0.41	N	0.94	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7758	7758	C	T	MI.5555	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	173	58	A	V	gCt/gTt	3.06	0.99	0	probably_damaging	0.99	neutral	0.32	neutral	1.52	neutral	-1.87	deleterious	-3.5	medium_impact	2.44	0.64	neutral	0.66	neutral	4.27	24.00	deleterious	0.44	0.55	NA	NA	0.52	disease	0.49	neutral	0.32	neutral	4	0.99	deleterious	0.17	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	0.02	medium_impact	1.18	medium_impact	0.67	0.85	68.28	18.75	0.53	P	0.79	disease_causing	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7760	7760	C	A	MI.5556	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	175	59	Q	K	Cag/Aag	-13.77	0	0	probably_damaging	0.91	neutral	0.25	neutral	1.37	neutral	-1.59	deleterious	-3.73	high_impact	3.58	0.3	damaging	0.22	damaging	3.90	23.50	deleterious	0.55	0.6	NA	NA	0.8	disease	0.65	disease	0.65	disease	3	0.94	neutral	0.17	neutral	2	deleterious	0.79	deleterious	-1.66	low_impact	-0.06	medium_impact	2.25	high_impact	0.59	0.8	67.84	19.24	0.53	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7760	7760	C	G	MI.5557	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	175	59	Q	E	Cag/Gag	-13.77	0	0	possibly_damaging	0.82	neutral	0.52	neutral	1.37	neutral	-1.59	deleterious	-2.73	medium_impact	3.15	0.31	damaging	0.29	neutral	2.95	22.10	deleterious	0.49	0.55	NA	NA	0.73	disease	0.64	disease	0.54	disease	1	0.8	neutral	0.35	neutral	0	NA	0.77	deleterious	-1.33	low_impact	0.22	medium_impact	1.85	medium_impact	0.57	0.8	67.84	19.24	0.54	P	0.85	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7761	7761	A	T	MI.5558	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	176	59	Q	L	cAg/cTg	7.21	1	0	probably_damaging	0.91	neutral	0.54	neutral	1.29	deleterious	-3.12	deleterious	-6.68	high_impact	3.69	0.32	damaging	0.35	neutral	3.72	23.30	deleterious	0.35	0.5	NA	NA	0.83	disease	0.67	disease	0.67	disease	3	0.9	neutral	0.32	neutral	2	deleterious	0.82	deleterious	-1.66	low_impact	0.24	medium_impact	2.35	high_impact	0.24	0.8	67.84	19.24	0.75	P	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7761	7761	A	G	MI.5559	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	176	59	Q	R	cAg/cGg	7.21	1	0	probably_damaging	0.94	neutral	0.26	neutral	1.32	neutral	-2.3	deleterious	-3.77	high_impact	3.84	0.32	damaging	0.25	damaging	3.43	23.00	deleterious	0.59	0.65	NA	NA	0.81	disease	0.72	disease	0.68	disease	4	0.96	neutral	0.16	neutral	2	deleterious	0.84	deleterious	-1.83	low_impact	-0.05	medium_impact	2.5	high_impact	0.50	0.8	67.84	19.24	0.79	P	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8786	8786	T	C	MI.556	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	260	87	L	P	cTc/cCc	0.13	0	0	probably_damaging	1	deleterious	0	neutral	3.8	deleterious	-5.55	deleterious	-6.34	high_impact	4.49	0.22	damaging	0.41	neutral	3.89	23.50	deleterious	0.18	0.65	0.92	disease	0.71	disease	0.68	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	2.75	high_impact	0.72	0.9	14.6	18.39	0.9	P	1.00	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7761	7761	A	C	MI.5560	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	176	59	Q	P	cAg/cCg	7.21	1	0	probably_damaging	0.98	neutral	0.21	neutral	1.28	deleterious	-3.79	deleterious	-5.37	high_impact	3.69	0.33	damaging	0.21	damaging	3.29	22.80	deleterious	0.16	0.45	NA	NA	0.85	disease	0.63	disease	0.67	disease	3	0.98	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-2.3	low_impact	-0.11	medium_impact	2.35	high_impact	0.41	0.8	67.84	19.24	0.71	P	0.95	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7762	7762	G	C	MI.5561	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	177	59	Q	H	caG/caC	8.59	1	0.01	probably_damaging	0.98	neutral	0.47	neutral	1.33	neutral	-2.15	deleterious	-4.52	low_impact	1.92	0.33	damaging	0.24	damaging	3.37	22.90	deleterious	0.52	0.6	NA	NA	0.69	disease	0.49	neutral	0.15	neutral	7	0.98	deleterious	0.25	neutral	-2	neutral	0.85	deleterious	-2.3	low_impact	0.18	medium_impact	0.7	medium_impact	0.64	0.8	67.84	19.24	0.71	P	0.86	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7762	7762	G	T	MI.5562	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	177	59	Q	H	caG/caT	8.59	1	0.01	probably_damaging	0.98	neutral	0.47	neutral	1.33	neutral	-2.15	deleterious	-4.52	low_impact	1.92	0.33	damaging	0.24	damaging	3.46	23.00	deleterious	0.52	0.6	NA	NA	0.69	disease	0.49	neutral	0.15	neutral	7	0.98	deleterious	0.25	neutral	-2	neutral	0.85	deleterious	-2.3	low_impact	0.18	medium_impact	0.7	medium_impact	0.64	0.8	67.84	19.24	0.71	P	0.86	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7763	7763	G	C	MI.5563	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	178	60	E	Q	Gaa/Caa	3.29	1	0	probably_damaging	0.98	neutral	0.34	neutral	1.52	neutral	-0.52	neutral	-1.79	low_impact	1.9	0.56	damaging	0.46	neutral	2.18	17.41	deleterious	0.54	0.6	NA	NA	0.21	neutral	0.28	neutral	0.19	neutral	6	0.98	neutral	0.18	neutral	-2	neutral	0.70	deleterious	-2.3	low_impact	0.05	medium_impact	0.68	medium_impact	0.73	0.85	67.4	19.04	0.55	P	0.76	disease_causing	0.96	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7763	7763	G	A	MI.5564	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	178	60	E	K	Gaa/Aaa	3.29	1	0	probably_damaging	0.97	neutral	0.33	neutral	1.55	neutral	1.15	deleterious	-2.81	low_impact	1.8	0.63	neutral	0.28	damaging	3.33	22.90	deleterious	0.38	0.5	NA	NA	0.36	neutral	0.51	disease	0.22	neutral	6	0.98	neutral	0.18	neutral	-2	neutral	0.74	deleterious	-2.13	low_impact	0.04	medium_impact	0.58	medium_impact	0.51	0.8	67.4	19.04	0.53	P	0.99	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7764	7764	A	G	MI.5565	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	179	60	E	G	gAa/gGa	7.44	1	0	probably_damaging	0.99	neutral	0.36	neutral	1.51	neutral	-1.44	deleterious	-4.89	low_impact	1.66	0.61	neutral	0.59	neutral	3.14	22.60	deleterious	0.37	0.5	NA	NA	0.27	neutral	0.53	disease	0.32	neutral	4	0.99	deleterious	0.19	neutral	-2	neutral	0.72	deleterious	-2.58	low_impact	0.07	medium_impact	0.45	medium_impact	0.60	0.8	67.4	19.04	0.57	P	0.64	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7764	7764	A	C	MI.5566	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	179	60	E	A	gAa/gCa	7.44	1	0	probably_damaging	0.98	neutral	0.51	neutral	1.57	neutral	0.39	deleterious	-3.94	low_impact	1.58	0.65	neutral	0.73	neutral	2.57	19.91	deleterious	0.32	0.5	NA	NA	0.22	neutral	0.44	neutral	0.16	neutral	7	0.98	deleterious	0.27	neutral	-2	neutral	0.71	deleterious	-2.3	low_impact	0.21	medium_impact	0.38	medium_impact	0.59	0.8	67.4	19.04	0.57	P	0.66	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7764	7764	A	T	MI.5567	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	179	60	E	V	gAa/gTa	7.44	1	0	probably_damaging	0.99	neutral	0.53	neutral	1.63	neutral	-0.95	deleterious	-4.79	low_impact	1.42	0.66	neutral	0.74	neutral	4.16	23.80	deleterious	0.28	0.45	NA	NA	0.35	neutral	0.46	neutral	0.15	neutral	7	0.98	deleterious	0.27	neutral	-2	neutral	0.74	deleterious	-2.58	low_impact	0.23	medium_impact	0.23	medium_impact	0.71	0.85	67.4	19.04	0.5	P	0.82	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7765	7765	A	C	MI.5568	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	180	60	E	D	gaA/gaC	3.75	1	0	possibly_damaging	0.9	neutral	0.21	neutral	1.51	neutral	-0.8	neutral	-2.33	medium_impact	2.35	0.51	damaging	0.37	neutral	3.52	23.10	deleterious	0.49	0.55	NA	NA	0.25	neutral	0.41	neutral	0.16	neutral	7	0.93	neutral	0.16	neutral	0	NA	0.66	deleterious	-1.61	low_impact	-0.11	medium_impact	1.1	medium_impact	0.85	0.9	67.4	19.04	0.74	P	0.81	disease_causing	0.95	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7765	7765	A	T	MI.5569	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	180	60	E	D	gaA/gaT	3.75	1	0	possibly_damaging	0.9	neutral	0.21	neutral	1.51	neutral	-0.8	neutral	-2.33	medium_impact	2.35	0.51	damaging	0.37	neutral	3.67	23.30	deleterious	0.49	0.55	NA	NA	0.25	neutral	0.41	neutral	0.16	neutral	7	0.93	neutral	0.16	neutral	0	NA	0.66	deleterious	-1.61	low_impact	-0.11	medium_impact	1.1	medium_impact	0.85	0.9	67.4	19.04	0.73	P	0.81	disease_causing	0.95	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8788	8788	C	A	MI.557	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	262	88	L	M	Ctg/Atg	-11.9	0	0	probably_damaging	0.91	neutral	0.11	neutral	4.04	deleterious	-3.26	neutral	-1.66	medium_impact	2.53	0.94	neutral	0.21	damaging	3.61	23.20	deleterious	0.36	0.65	0.69	disease	0.33	neutral	0.56	disease	0.62	disease	2	0.97	neutral	0.1	neutral	1	deleterious	0.69	deleterious	-1.71	low_impact	-0.22	medium_impact	1.07	medium_impact	0.75	0.9	15.49	18.89	0.4	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7766	7766	A	G	MI.5570	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	181	61	M	V	Ata/Gta	1.68	1	0	probably_damaging	0.94	neutral	0.48	neutral	1.77	neutral	1.85	neutral	1.94	neutral_impact	-1.27	0.78	neutral	0.93	neutral	0.87	9.88	deleterious	0.45	0.55	NA	NA	0.3	neutral	0.31	neutral	0.13	neutral	7	0.93	neutral	0.27	neutral	-2	neutral	0.64	deleterious	-1.83	low_impact	0.19	medium_impact	-2.3	low_impact	0.84	0.9	32.6	67.92	0.38	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7766	7766	A	T	MI.5571	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	181	61	M	L	Ata/Tta	1.68	1	0	possibly_damaging	0.9	neutral	0.92	neutral	1.76	neutral	1.79	neutral	0.38	neutral_impact	-1.26	0.65	neutral	0.31	neutral	2.08	16.73	deleterious	0.39	0.5	NA	NA	0.28	neutral	0.32	neutral	0.12	neutral	8	0.89	neutral	0.51	deleterious	-3	neutral	0.60	deleterious	-1.61	low_impact	0.79	medium_impact	-2.29	low_impact	0.77	0.85	32.6	67.92	0.38	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7766	7766	A	C	MI.5572	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	181	61	M	L	Ata/Cta	1.68	1	0	possibly_damaging	0.9	neutral	0.92	neutral	1.76	neutral	1.79	neutral	0.38	neutral_impact	-1.26	0.65	neutral	0.31	neutral	2.02	16.32	deleterious	0.39	0.5	NA	NA	0.28	neutral	0.32	neutral	0.12	neutral	8	0.89	neutral	0.51	deleterious	-3	neutral	0.60	deleterious	-1.61	low_impact	0.79	medium_impact	-2.29	low_impact	0.77	0.85	32.6	67.92	0.36	N	0.35	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7767	7767	T	C	MI.5573	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	182	61	M	T	aTa/aCa	0.52	0.99	0	probably_damaging	0.97	neutral	0.42	neutral	1.56	neutral	-0.56	neutral	-1.91	low_impact	0.86	0.6	damaging	0.29	neutral	2.96	22.10	deleterious	0.28	0.45	NA	NA	0.5	neutral	0.54	disease	0.55	disease	1	0.97	neutral	0.23	neutral	-2	neutral	0.76	deleterious	-2.13	low_impact	0.13	medium_impact	-0.3	medium_impact	0.43	0.8	32.6	67.92	0.34	N	0.45	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7767	7767	T	A	MI.5574	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	182	61	M	K	aTa/aAa	0.52	0.99	0	probably_damaging	0.97	neutral	0.22	neutral	1.53	neutral	-1.82	deleterious	-3.75	low_impact	1.32	0.52	damaging	0.24	damaging	4.24	23.90	deleterious	0.15	0.4	NA	NA	0.66	disease	0.67	disease	0.66	disease	3	0.98	deleterious	0.13	neutral	-2	neutral	0.81	deleterious	-2.13	low_impact	-0.1	medium_impact	0.13	medium_impact	0.55	0.8	32.6	67.92	0.4	N	0.74	polymorphism	0.94	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7768	7768	A	C	MI.5575	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	183	61	M	I	atA/atC	7.44	1	0.04	probably_damaging	0.96	neutral	1	neutral	2.03	neutral	2.95	neutral	2.16	neutral_impact	-2.42	0.75	neutral	0.7	neutral	0.58	7.99	deleterious	0.44	0.55	NA	NA	0.08	neutral	0.23	neutral	0.2	neutral	6	0.95	neutral	0.52	deleterious	-2	neutral	0.63	deleterious	-2.01	low_impact	1.86	high_impact	-3.37	low_impact	0.90	0.95	32.6	67.92	0.47	N	0.01	polymorphism	0.93	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7768	7768	A	T	MI.5576	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	183	61	M	I	atA/atT	7.44	1	0.04	probably_damaging	0.96	neutral	1	neutral	2.03	neutral	2.95	neutral	2.16	neutral_impact	-2.42	0.75	neutral	0.7	neutral	0.71	8.90	deleterious	0.44	0.55	NA	NA	0.08	neutral	0.23	neutral	0.2	neutral	6	0.95	neutral	0.52	deleterious	-2	neutral	0.63	deleterious	-2.01	low_impact	1.86	high_impact	-3.37	low_impact	0.90	0.95	32.6	67.92	0.49	N	0.01	polymorphism	0.93	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7769	7769	G	A	MI.5577	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	184	62	E	K	Gaa/Aaa	-5.47	0	0	probably_damaging	1	neutral	0.3	neutral	-0.44	deleterious	-7.15	deleterious	-3.97	high_impact	4.65	0.28	damaging	0.17	damaging	4.44	24.20	deleterious	0.28	0.45	NA	NA	0.82	disease	0.88	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0	medium_impact	3.25	high_impact	0.68	0.85	68.72	19.33	0.79	P	0.99	polymorphism	0.95	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7769	7769	G	C	MI.5578	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	184	62	E	Q	Gaa/Caa	-5.47	0	0	probably_damaging	1	neutral	0.3	neutral	-0.44	deleterious	-7.49	deleterious	-2.97	high_impact	4.65	0.27	damaging	0.4	neutral	3.26	22.80	deleterious	0.33	0.5	NA	NA	0.69	disease	0.82	disease	0.67	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0	medium_impact	3.25	high_impact	0.70	0.85	68.72	19.33	0.85	P	0.76	polymorphism	0.99	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7770	7770	A	G	MI.5579	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	185	62	E	G	gAa/gGa	7.21	1	0	probably_damaging	1	neutral	0.36	neutral	-0.44	deleterious	-7.48	deleterious	-6.95	high_impact	4.65	0.25	damaging	0.42	neutral	3.98	23.60	deleterious	0.23	0.45	NA	NA	0.72	disease	0.85	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.07	medium_impact	3.25	high_impact	0.43	0.8	68.72	19.33	0.92	P	0.64	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8788	8788	C	G	MI.558	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	262	88	L	V	Ctg/Gtg	-11.9	0	0	benign	0.39	neutral	0.14	neutral	4.23	neutral	-0.81	deleterious	-2.53	low_impact	1.7	0.9	neutral	0.12	damaging	1.70	14.40	neutral	0.33	0.65	0.3	neutral	0.35	neutral	0.56	disease	0.46	neutral	1	0.84	neutral	0.38	neutral	-6	neutral	0.36	neutral	-0.57	medium_impact	-0.15	medium_impact	0.36	medium_impact	0.72	0.9	15.49	18.89	0.38	N	0.68	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7770	7770	A	T	MI.5580	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	185	62	E	V	gAa/gTa	7.21	1	0	probably_damaging	1	neutral	0.49	neutral	-0.46	deleterious	-8.6	deleterious	-6.96	high_impact	4.3	0.27	damaging	0.28	neutral	3.94	23.50	deleterious	0.17	0.45	NA	NA	0.82	disease	0.84	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.2	medium_impact	2.93	high_impact	0.70	0.85	68.72	19.33	0.88	P	0.82	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7770	7770	A	C	MI.5581	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	185	62	E	A	gAa/gCa	7.21	1	0	probably_damaging	1	neutral	0.5	neutral	-0.44	deleterious	-7.38	deleterious	-5.96	high_impact	4.65	0.28	damaging	0.35	neutral	3.46	23.00	deleterious	0.2	0.45	NA	NA	0.66	disease	0.82	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	0.21	medium_impact	3.25	high_impact	0.58	0.8	68.72	19.33	0.91	P	0.66	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7771	7771	A	T	MI.5582	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	186	62	E	D	gaA/gaT	8.59	1	0	probably_damaging	0.98	neutral	0.2	neutral	-0.41	deleterious	-6.22	deleterious	-2.96	high_impact	4.11	0.3	damaging	0.3	neutral	3.73	23.30	deleterious	0.37	0.5	NA	NA	0.65	disease	0.84	disease	0.68	disease	4	0.99	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-2.3	low_impact	-0.13	medium_impact	2.75	high_impact	0.69	0.85	68.72	19.33	0.82	P	0.81	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7771	7771	A	C	MI.5583	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	186	62	E	D	gaA/gaC	8.59	1	0	probably_damaging	0.98	neutral	0.2	neutral	-0.41	deleterious	-6.22	deleterious	-2.96	high_impact	4.11	0.3	damaging	0.3	neutral	3.63	23.20	deleterious	0.37	0.5	NA	NA	0.65	disease	0.84	disease	0.68	disease	4	0.99	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-2.3	low_impact	-0.13	medium_impact	2.75	high_impact	0.69	0.85	68.72	19.33	0.82	P	0.81	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7772	7772	A	C	MI.5584	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	187	63	T	P	Acc/Ccc	-0.17	0.69	0	possibly_damaging	0.7	neutral	0.16	neutral	1.43	deleterious	-3.55	deleterious	-3.4	medium_impact	2.82	0.6	neutral	0.38	neutral	3.05	22.40	deleterious	0.11	0.4	NA	NA	0.79	disease	0.51	disease	0.57	disease	1	0.87	neutral	0.23	neutral	0	NA	0.64	deleterious	-1.06	low_impact	-0.19	medium_impact	1.54	medium_impact	0.66	0.8	69.16	15.32	0.32	N	0.90	polymorphism	0.59	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7772	7772	A	T	MI.5585	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	187	63	T	S	Acc/Tcc	-0.17	0.69	0	benign	0.11	neutral	0.33	neutral	1.46	neutral	-2.07	neutral	-1.98	low_impact	1.62	0.72	neutral	0.56	neutral	1.23	11.90	neutral	0.38	0.5	NA	NA	0.41	neutral	0.48	neutral	0.14	neutral	7	0.62	neutral	0.61	deleterious	-6	neutral	0.20	neutral	0.13	medium_impact	0.04	medium_impact	0.41	medium_impact	0.81	0.85	69.16	15.32	0.39	N	0.80	polymorphism	0.96	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7772	7772	A	G	MI.5586	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	187	63	T	A	Acc/Gcc	-0.17	0.69	0	benign	0.05	neutral	0.26	neutral	1.49	neutral	-1.28	neutral	-2.12	low_impact	1.92	0.78	neutral	0.63	neutral	0.25	5.15	deleterious	0.54	0.6	NA	NA	0.35	neutral	0.45	neutral	0.14	neutral	7	0.72	neutral	0.61	deleterious	-6	neutral	0.15	neutral	0.47	medium_impact	-0.05	medium_impact	0.7	medium_impact	0.51	0.8	69.16	15.32	0.36	N	0.65	polymorphism	0.88	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7773	7773	C	G	MI.5587	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	188	63	T	S	aCc/aGc	3.06	0.97	0	benign	0.11	neutral	0.33	neutral	1.46	neutral	-2.07	neutral	-1.98	low_impact	1.62	0.72	neutral	0.56	neutral	1.52	13.44	neutral	0.38	0.5	NA	NA	0.41	neutral	0.48	neutral	0.14	neutral	7	0.62	neutral	0.61	deleterious	-6	neutral	0.20	neutral	0.13	medium_impact	0.04	medium_impact	0.41	medium_impact	0.81	0.85	69.16	15.32	0.53	P	0.80	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7773	7773	C	A	MI.5588	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	188	63	T	N	aCc/aAc	3.06	0.97	0	possibly_damaging	0.59	neutral	0.22	neutral	1.44	deleterious	-3.27	deleterious	-2.97	medium_impact	2.82	0.66	neutral	0.53	neutral	3.39	23.00	deleterious	0.29	0.45	NA	NA	0.58	disease	0.52	disease	0.53	disease	1	0.78	neutral	0.32	neutral	0	NA	0.58	deleterious	-0.87	medium_impact	-0.1	medium_impact	1.54	medium_impact	0.77	0.85	69.16	15.32	0.48	N	0.87	polymorphism	0.91	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7773	7773	C	T	MI.5589	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	188	63	T	I	aCc/aTc	3.06	0.97	0	benign	0.01	neutral	1	neutral	1.76	neutral	1.13	neutral	-0.64	neutral_impact	-0.88	0.78	neutral	0.77	neutral	-0.91	0.03	neutral	0.29	0.45	NA	NA	0.23	neutral	0.35	neutral	0.14	neutral	7	0.01	neutral	1	deleterious	-6	neutral	0.13	neutral	1.14	medium_impact	1.86	high_impact	-1.93	low_impact	0.70	0.85	69.16	15.32	0.33	N	0.77	polymorphism	0.91	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8789	8789	T	C	MI.559	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	263	88	L	P	cTg/cCg	-1.95	0	0	probably_damaging	0.94	deleterious	0	neutral	4	deleterious	-5.85	deleterious	-6.11	high_impact	4	0.8	neutral	0.1	damaging	3.80	23.40	deleterious	0.15	0.65	0.92	disease	0.75	disease	0.67	disease	0.69	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.85	deleterious	-1.89	low_impact	-1.4	low_impact	2.33	high_impact	0.65	0.9	15.49	18.89	0.28	N	0.95	polymorphism	0.88	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7775	7775	G	C	MI.5590	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	190	64	V	L	Gtc/Ctc	-14.7	0	0	benign	0.01	neutral	0.87	neutral	1.57	neutral	-0.11	neutral	-1.72	low_impact	1.17	0.59	damaging	0.48	neutral	1.56	13.63	neutral	0.46	0.55	NA	NA	0.52	disease	0.42	neutral	0.2	neutral	6	0.1	neutral	0.93	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	0.66	medium_impact	-0.01	medium_impact	0.77	0.85	63.88	15.77	0.29	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7775	7775	G	T	MI.5591	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	190	64	V	F	Gtc/Ttc	-14.7	0	0	benign	0.18	neutral	0.84	neutral	1.33	deleterious	-3.09	deleterious	-3.72	low_impact	1.64	0.47	damaging	0.47	neutral	1.94	15.83	deleterious	0.23	0.45	NA	NA	0.76	disease	0.48	neutral	0.16	neutral	7	0.09	neutral	0.83	deleterious	-6	neutral	0.32	neutral	-0.11	medium_impact	0.6	medium_impact	0.43	medium_impact	0.70	0.85	63.88	15.77	0.34	N	0.68	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7775	7775	G	A	MI.5592	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	190	64	V	I	Gtc/Atc	-14.7	0	0	benign	0	neutral	0.97	neutral	1.86	neutral	1.1	neutral	0.17	neutral_impact	-0.85	0.86	neutral	0.99	neutral	-1.14	0.01	neutral	0.53	0.6	NA	NA	0.06	neutral	0.36	neutral	0.12	neutral	8	0.02	neutral	0.99	deleterious	-6	neutral	0.09	neutral	2.08	high_impact	1.04	medium_impact	-1.9	low_impact	0.82	0.85	63.88	15.77	0.36	N	0.00	polymorphism	1	0.01	.	.	.	.	.	colonic crypts, thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7776	7776	T	C	MI.5593	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	191	64	V	A	gTc/gCc	0.29	0.08	0	benign	0.07	neutral	0.58	neutral	1.36	neutral	-2.07	deleterious	-3.83	low_impact	1.29	0.59	damaging	0.64	neutral	0.42	6.75	deleterious	0.37	0.5	NA	NA	0.31	neutral	0.52	disease	0.27	neutral	5	0.34	neutral	0.76	deleterious	-6	neutral	0.16	neutral	0.33	medium_impact	0.28	medium_impact	0.1	medium_impact	0.54	0.8	63.88	15.77	0.39	N	0.67	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7776	7776	T	G	MI.5594	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	191	64	V	G	gTc/gGc	0.29	0.08	0	benign	0.11	neutral	0.47	neutral	1.31	deleterious	-4.2	deleterious	-6.82	medium_impact	2.42	0.5	damaging	0.5	neutral	1.91	15.64	deleterious	0.24	0.45	NA	NA	0.71	disease	0.69	disease	0.7	disease	4	0.45	neutral	0.68	deleterious	-3	neutral	0.31	neutral	0.13	medium_impact	0.18	medium_impact	1.16	medium_impact	0.58	0.8	63.88	15.77	0.38	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7776	7776	T	A	MI.5595	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	191	64	V	D	gTc/gAc	0.29	0.08	0	benign	0.24	neutral	0.21	neutral	1.3	deleterious	-4.96	deleterious	-6.27	medium_impact	3.31	0.48	damaging	0.4	neutral	2.58	20.00	deleterious	0.1	0.4	NA	NA	0.83	disease	0.77	disease	0.72	disease	4	0.75	neutral	0.49	deleterious	-3	neutral	0.38	neutral	-0.25	medium_impact	-0.11	medium_impact	2	medium_impact	0.57	0.8	63.88	15.77	0.47	N	0.91	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7778	7778	T	C	MI.5596	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	193	65	W	R	Tga/Cga	-6.63	0	0	probably_damaging	1	neutral	0.1	neutral	-0.97	deleterious	-9.07	deleterious	-13.89	high_impact	4.24	0.3	damaging	0.18	damaging	3.47	23.00	deleterious	0.27	0.45	NA	NA	0.91	disease	0.87	disease	0.75	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	-0.32	medium_impact	2.87	high_impact	0.34	0.8	67.84	19.21	0.61	P	0.96	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7778	7778	T	G	MI.5597	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	193	65	W	G	Tga/Gga	-6.63	0	0	probably_damaging	1	neutral	0.15	neutral	-0.97	deleterious	-9.78	deleterious	-12.91	high_impact	3.9	0.31	damaging	0.33	neutral	3.79	23.40	deleterious	0.24	0.45	NA	NA	0.87	disease	0.84	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.21	medium_impact	2.55	high_impact	0.30	0.8	67.84	19.21	0.63	P	0.98	polymorphism	0.99	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7779	7779	G	C	MI.5598	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	194	65	W	S	tGa/tCa	7.44	1	0	probably_damaging	1	neutral	0.11	neutral	-0.97	deleterious	-9.75	deleterious	-13.89	high_impact	4.24	0.3	damaging	0.29	neutral	3.94	23.50	deleterious	0.22	0.45	NA	NA	0.91	disease	0.83	disease	0.74	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.3	medium_impact	2.87	high_impact	0.26	0.8	67.84	19.21	0.65	P	0.97	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7779	7779	G	T	MI.5599	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	194	65	W	L	tGa/tTa	7.44	1	0	probably_damaging	1	neutral	0.45	neutral	-0.96	deleterious	-8.54	deleterious	-12.91	high_impact	4.58	0.33	damaging	0.36	neutral	4.13	23.80	deleterious	0.2	0.45	NA	NA	0.84	disease	0.83	disease	0.71	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.16	medium_impact	3.19	high_impact	0.30	0.8	67.84	19.21	0.7	P	0.98	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8551	8551	T	G	MI.56	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	25	9	F	V	Ttc/Gtc	0.59	0.99	0	probably_damaging	0.95	deleterious	0	neutral	3.88	neutral	-1.51	deleterious	-6.14	medium_impact	3.24	0.54	damaging	0.62	neutral	3.86	23.50	deleterious	0.38	0.65	0.62	disease	0.84	disease	0.84	disease	0.85	disease	7	1	deleterious	0.03	neutral	5	deleterious	0.79	deleterious	-1.97	low_impact	-1.4	low_impact	1.68	medium_impact	0.43	0.9	49.56	8.77	0.52	P	0.98	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8789	8789	T	G	MI.560	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	263	88	L	R	cTg/cGg	-1.95	0	0	probably_damaging	0.91	deleterious	0	neutral	4	deleterious	-5.44	deleterious	-5.19	high_impact	4	0.83	neutral	0.09	damaging	4.05	23.70	deleterious	0.15	0.65	0.9	disease	0.79	disease	0.79	disease	0.76	disease	5	1	deleterious	0.05	neutral	6	deleterious	0.83	deleterious	-1.71	low_impact	-1.4	low_impact	2.33	high_impact	0.56	0.9	15.49	18.89	0.38	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7780	7780	A	T	MI.5600	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	195	65	W	C	tgA/tgT	9.29	1	0	probably_damaging	1	deleterious	0.04	neutral	-0.95	deleterious	-7.71	deleterious	-12.9	high_impact	4.24	0.27	damaging	0.19	damaging	4.05	23.70	deleterious	0.26	0.45	NA	NA	0.88	disease	0.87	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-3.52	low_impact	-0.56	medium_impact	2.87	high_impact	0.35	0.8	67.84	19.21	0.8	P	0.94	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7780	7780	A	C	MI.5601	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	195	65	W	C	tgA/tgC	9.29	1	0	probably_damaging	1	deleterious	0.04	neutral	-0.95	deleterious	-7.71	deleterious	-12.9	high_impact	4.24	0.27	damaging	0.19	damaging	3.93	23.50	deleterious	0.26	0.45	NA	NA	0.88	disease	0.87	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-3.52	low_impact	-0.56	medium_impact	2.87	high_impact	0.35	0.8	67.84	19.21	0.79	P	0.94	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7781	7781	A	T	MI.5602	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	196	66	T	S	Act/Tct	4.67	1	0	probably_damaging	0.97	neutral	0.38	neutral	0.49	deleterious	-3.49	deleterious	-3.95	high_impact	3.58	0.15	damaging	0.04	damaging	3.26	22.80	deleterious	0.35	0.5	NA	NA	0.72	disease	0.77	disease	0.69	disease	4	0.97	neutral	0.21	neutral	2	deleterious	0.83	deleterious	-2.13	low_impact	0.09	medium_impact	2.25	high_impact	0.75	0.85	69.16	19.07	0.88	P	0.80	disease_causing	0.79	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7781	7781	A	C	MI.5603	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	196	66	T	P	Act/Cct	4.67	1	0	probably_damaging	1	neutral	0.13	neutral	0.34	deleterious	-6.78	deleterious	-5.94	high_impact	4.62	0.17	damaging	0.06	damaging	3.46	23.00	deleterious	0.15	0.4	NA	NA	0.82	disease	0.86	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.25	medium_impact	3.23	high_impact	0.61	0.8	69.16	19.07	0.87	P	0.90	disease_causing	0.98	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7781	7781	A	G	MI.5604	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	196	66	T	A	Act/Gct	4.67	1	0	probably_damaging	0.97	neutral	0.34	neutral	0.37	deleterious	-5.23	deleterious	-4.95	high_impact	4.27	0.22	damaging	0.1	damaging	3.40	23.00	deleterious	0.46	0.55	NA	NA	0.66	disease	0.78	disease	0.68	disease	4	0.97	neutral	0.19	neutral	2	deleterious	0.79	deleterious	-2.13	low_impact	0.05	medium_impact	2.9	high_impact	0.54	0.8	69.16	19.07	0.86	P	0.65	disease_causing	0.92	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7782	7782	C	G	MI.5605	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	197	66	T	S	aCt/aGt	6.98	1	0	probably_damaging	0.97	neutral	0.38	neutral	0.49	deleterious	-3.49	deleterious	-3.95	high_impact	3.58	0.15	damaging	0.04	damaging	3.37	22.90	deleterious	0.35	0.5	NA	NA	0.72	disease	0.77	disease	0.69	disease	4	0.97	neutral	0.21	neutral	2	deleterious	0.83	deleterious	-2.13	low_impact	0.09	medium_impact	2.25	high_impact	0.75	0.85	69.16	19.07	0.87	P	0.80	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7782	7782	C	T	MI.5606	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	197	66	T	I	aCt/aTt	6.98	1	0	probably_damaging	1	neutral	0.37	neutral	0.35	deleterious	-5.78	deleterious	-5.95	high_impact	4.27	0.16	damaging	0.02	damaging	3.78	23.40	deleterious	0.38	0.5	NA	NA	0.87	disease	0.78	disease	0.71	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.08	medium_impact	2.9	high_impact	0.72	0.85	69.16	19.07	0.83	P	0.77	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7782	7782	C	A	MI.5607	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	197	66	T	N	aCt/aAt	6.98	1	0	probably_damaging	1	neutral	0.23	neutral	0.35	deleterious	-5.95	deleterious	-4.95	high_impact	4.62	0.16	damaging	0.03	damaging	3.64	23.20	deleterious	0.39	0.5	NA	NA	0.81	disease	0.78	disease	0.69	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.09	medium_impact	3.23	high_impact	0.78	0.85	69.16	19.07	0.85	P	0.87	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7784	7784	A	T	MI.5608	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	199	67	I	F	Atc/Ttc	-12.85	0	0	benign	0.18	neutral	0.09	neutral	1.14	deleterious	-3.84	deleterious	-3.7	medium_impact	2.45	0.46	damaging	0.29	neutral	2.10	16.85	deleterious	0.48	0.55	NA	NA	0.78	disease	0.7	disease	0.67	disease	3	0.9	neutral	0.46	neutral	-3	neutral	0.35	neutral	-0.11	medium_impact	-0.35	medium_impact	1.19	medium_impact	0.75	0.85	67.4	18.75	0.34	N	0.93	polymorphism	0.94	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7784	7784	A	G	MI.5609	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	199	67	I	V	Atc/Gtc	-12.85	0	0	benign	0	neutral	0.33	neutral	1.42	neutral	-0.68	neutral	-0.48	low_impact	1	0.8	neutral	0.89	neutral	-0.75	0.06	neutral	0.68	0.7	NA	NA	0.16	neutral	0.42	neutral	0.2	neutral	6	0.67	neutral	0.67	deleterious	-6	neutral	0.14	neutral	2.08	high_impact	0.04	medium_impact	-0.17	medium_impact	0.61	0.8	67.4	18.75	0.4	N	0.28	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8789	8789	T	A	MI.561	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	263	88	L	Q	cTg/cAg	-1.95	0	0	probably_damaging	0.94	deleterious	0	neutral	4	deleterious	-5.48	deleterious	-5.18	high_impact	4	0.8	neutral	0.11	damaging	4.09	23.70	deleterious	0.19	0.65	0.91	disease	0.73	disease	0.69	disease	0.68	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-1.89	low_impact	-1.4	low_impact	2.33	high_impact	0.66	0.9	15.49	18.89	0.3	N	0.91	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7784	7784	A	C	MI.5610	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	199	67	I	L	Atc/Ctc	-12.85	0	0	benign	0.01	neutral	0.38	neutral	1.29	neutral	-1.49	neutral	-1.73	low_impact	1.51	0.66	neutral	0.74	neutral	0.71	8.86	deleterious	0.41	0.5	NA	NA	0.54	disease	0.44	neutral	0.15	neutral	7	0.61	neutral	0.69	deleterious	-6	neutral	0.19	neutral	1.14	medium_impact	0.09	medium_impact	0.31	medium_impact	0.68	0.85	67.4	18.75	0.41	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7785	7785	T	A	MI.5611	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	200	67	I	N	aTc/aAc	0.29	0.02	0	benign	0.2	deleterious	0.02	neutral	1.12	deleterious	-5.05	deleterious	-6.21	high_impact	4.08	0.53	damaging	0.28	damaging	2.60	20.20	deleterious	0.37	0.5	NA	NA	0.81	disease	0.71	disease	0.69	disease	4	0.98	neutral	0.41	neutral	2	deleterious	0.40	neutral	-0.16	medium_impact	-0.73	medium_impact	2.72	high_impact	0.64	0.8	67.4	18.75	0.35	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7785	7785	T	G	MI.5612	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	200	67	I	S	aTc/aGc	0.29	0.02	0	benign	0.13	neutral	0.11	neutral	1.14	deleterious	-3.92	deleterious	-5.17	medium_impact	2.64	0.53	damaging	0.36	neutral	2.30	18.19	deleterious	0.38	0.5	NA	NA	0.83	disease	0.69	disease	0.66	disease	3	0.88	neutral	0.49	deleterious	-3	neutral	0.29	neutral	0.05	medium_impact	-0.3	medium_impact	1.37	medium_impact	0.55	0.8	67.4	18.75	0.33	N	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7785	7785	T	C	MI.5613	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	200	67	I	T	aTc/aCc	0.29	0.02	0	benign	0	neutral	0.26	neutral	1.2	neutral	-2.47	deleterious	-3.95	medium_impact	2.1	0.64	neutral	0.36	neutral	1.33	12.44	neutral	0.57	0.65	NA	NA	0.66	disease	0.62	disease	0.54	disease	1	0.74	neutral	0.63	deleterious	-3	neutral	0.21	neutral	2.08	high_impact	-0.05	medium_impact	0.86	medium_impact	0.57	0.8	67.4	18.75	0.37	N	0.91	polymorphism	1	0.12	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7786	7786	C	A	MI.5614	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	201	67	I	M	atC/atA	5.83	0.89	0	benign	0.32	neutral	0.05	neutral	1.16	deleterious	-3.33	neutral	-2.5	medium_impact	2.4	0.59	damaging	0.39	neutral	2.08	16.75	deleterious	0.64	0.7	NA	NA	0.56	disease	0.46	neutral	0.15	neutral	7	0.94	neutral	0.37	neutral	-3	neutral	0.25	neutral	-0.42	medium_impact	-0.5	medium_impact	1.15	medium_impact	0.89	0.9	67.4	18.75	0.48	N	0.77	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7786	7786	C	G	MI.5615	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	201	67	I	M	atC/atG	5.83	0.89	0	benign	0.32	neutral	0.05	neutral	1.16	deleterious	-3.33	neutral	-2.5	medium_impact	2.4	0.59	damaging	0.39	neutral	1.61	13.91	neutral	0.64	0.7	NA	NA	0.56	disease	0.46	neutral	0.15	neutral	7	0.94	neutral	0.37	neutral	-3	neutral	0.25	neutral	-0.42	medium_impact	-0.5	medium_impact	1.15	medium_impact	0.89	0.9	67.4	18.75	0.48	N	0.77	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7787	7787	C	G	MI.5616	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	202	68	L	V	Ctg/Gtg	-3.86	0	0	probably_damaging	0.94	neutral	0.37	neutral	1.49	neutral	1.05	neutral	-2.4	medium_impact	2.05	0.53	damaging	0.2	damaging	3.26	22.80	deleterious	0.47	0.55	NA	NA	0.52	disease	0.43	neutral	0.17	neutral	7	0.94	neutral	0.22	neutral	1	deleterious	0.75	deleterious	-1.83	low_impact	0.08	medium_impact	0.82	medium_impact	0.48	0.8	68.28	18.9	0.34	N	0.60	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7787	7787	C	A	MI.5617	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	202	68	L	M	Ctg/Atg	-3.86	0	0	probably_damaging	1	neutral	0.22	neutral	1.35	neutral	-2.09	neutral	-1.01	low_impact	1.55	0.6	damaging	0.57	neutral	2.49	19.42	deleterious	0.34	0.5	NA	NA	0.35	neutral	0.4	neutral	0.15	neutral	7	1	deleterious	0.11	neutral	-2	neutral	0.76	deleterious	-3.52	low_impact	-0.1	medium_impact	0.35	medium_impact	0.56	0.8	68.28	18.9	0.48	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7788	7788	T	A	MI.5618	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	203	68	L	Q	cTg/cAg	-2.01	0	0	probably_damaging	1	neutral	0.2	neutral	1.32	deleterious	-3.24	deleterious	-5.07	high_impact	4.01	0.38	damaging	0.05	damaging	4.12	23.80	deleterious	0.2	0.45	NA	NA	0.74	disease	0.65	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	-0.13	medium_impact	2.65	high_impact	0.62	0.8	68.28	18.9	0.43	N	0.89	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7788	7788	T	G	MI.5619	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	203	68	L	R	cTg/cGg	-2.01	0	0	probably_damaging	1	neutral	0.2	neutral	1.32	deleterious	-3.07	deleterious	-5.26	high_impact	4.01	0.25	damaging	0.01	damaging	4.13	23.80	deleterious	0.17	0.45	NA	NA	0.88	disease	0.76	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.13	medium_impact	2.65	high_impact	0.48	0.8	68.28	18.9	0.69	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8791	8791	C	A	MI.562	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	265	89	P	T	Cct/Act	-7.28	0	0	probably_damaging	1	deleterious	0.02	neutral	2.16	deleterious	-6.12	deleterious	-7.12	high_impact	4.29	0.61	neutral	0.06	damaging	3.64	23.20	deleterious	0.21	0.65	0.74	disease	0.69	disease	0.73	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-0.66	medium_impact	2.58	high_impact	0.61	0.9	49.12	8.71	0.3	N	0.93	disease_causing	0.77	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7788	7788	T	C	MI.5620	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	203	68	L	P	cTg/cCg	-2.01	0	0	probably_damaging	1	neutral	0.31	neutral	1.31	deleterious	-3.65	deleterious	-6.2	high_impact	4.01	0.23	damaging	0.03	damaging	3.84	23.40	deleterious	0.17	0.45	NA	NA	0.87	disease	0.77	disease	0.72	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.01	medium_impact	2.65	high_impact	0.45	0.8	68.28	18.9	0.67	P	0.95	polymorphism	0.96	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7790	7790	C	A	MI.5621	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	205	69	P	T	Ccc/Acc	-8.47	0	0	probably_damaging	1	neutral	0.19	neutral	-1.39	deleterious	-9.49	deleterious	-7.93	high_impact	4.62	0.12	damaging	0.02	damaging	3.62	23.20	deleterious	0.24	0.45	NA	NA	0.79	disease	0.69	disease	0.66	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.14	medium_impact	3.23	high_impact	0.60	0.8	68.28	19.34	0.51	P	0.96	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7790	7790	C	T	MI.5622	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	205	69	P	S	Ccc/Tcc	-8.47	0	0	probably_damaging	1	neutral	0.15	neutral	-1.38	deleterious	-9.05	deleterious	-7.92	high_impact	4.28	0.11	damaging	0.03	damaging	3.80	23.40	deleterious	0.24	0.45	NA	NA	0.83	disease	0.69	disease	0.67	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.21	medium_impact	2.91	high_impact	0.28	0.8	68.28	19.34	0.52	P	0.94	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7790	7790	C	G	MI.5623	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	205	69	P	A	Ccc/Gcc	-8.47	0	0	probably_damaging	1	neutral	0.35	neutral	-1.38	deleterious	-8.75	deleterious	-7.93	high_impact	4.62	0.13	damaging	0.11	damaging	3.02	22.30	deleterious	0.19	0.45	NA	NA	0.71	disease	0.7	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.06	medium_impact	3.23	high_impact	0.58	0.8	68.28	19.34	0.57	P	0.90	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7791	7791	C	A	MI.5624	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	206	69	P	H	cCc/cAc	7.21	1	0	probably_damaging	1	neutral	0.14	neutral	-1.4	deleterious	-11.09	deleterious	-8.92	high_impact	4.28	0.08	damaging	0.02	damaging	3.90	23.50	deleterious	0.16	0.45	NA	NA	0.87	disease	0.79	disease	0.69	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.23	medium_impact	2.91	high_impact	0.57	0.8	68.28	19.34	0.78	P	0.79	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7791	7791	C	G	MI.5625	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	206	69	P	R	cCc/cGc	7.21	1	0	probably_damaging	1	neutral	0.2	neutral	-1.39	deleterious	-10.07	deleterious	-8.92	high_impact	4.62	0.12	damaging	0.02	damaging	3.51	23.10	deleterious	0.15	0.4	NA	NA	0.91	disease	0.78	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	-0.13	medium_impact	3.23	high_impact	0.53	0.8	68.28	19.34	0.76	P	0.85	disease_causing	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7791	7791	C	T	MI.5626	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	206	69	P	L	cCc/cTc	7.21	1	0	probably_damaging	1	neutral	0.26	neutral	-1.39	deleterious	-9.97	deleterious	-9.91	high_impact	4.62	0.07	damaging	0.02	damaging	4.36	24.10	deleterious	0.21	0.45	NA	NA	0.89	disease	0.68	disease	0.69	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.05	medium_impact	3.23	high_impact	0.70	0.85	68.28	19.34	0.74	P	0.92	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7793	7793	G	T	MI.5627	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	208	70	A	S	Gcc/Tcc	-2.24	0	0	probably_damaging	0.99	neutral	0.42	neutral	1.26	neutral	-2.03	deleterious	-2.89	medium_impact	2.4	0.46	damaging	0.52	neutral	3.64	23.20	deleterious	0.42	0.55	NA	NA	0.74	disease	0.59	disease	0.39	neutral	2	0.99	deleterious	0.22	neutral	1	deleterious	0.84	deleterious	-2.58	low_impact	0.13	medium_impact	1.15	medium_impact	0.77	0.85	68.72	19.4	0.42	N	0.71	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7793	7793	G	A	MI.5628	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	208	70	A	T	Gcc/Acc	-2.24	0	0	probably_damaging	1	neutral	0.46	neutral	1.34	neutral	-1.32	deleterious	-3.82	medium_impact	2.36	0.32	damaging	0.34	neutral	4.13	23.80	deleterious	0.46	0.55	NA	NA	0.69	disease	0.49	neutral	0.15	neutral	7	0.99	deleterious	0.23	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	0.17	medium_impact	1.11	medium_impact	0.72	0.85	68.72	19.4	0.63	P	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7793	7793	G	C	MI.5629	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	208	70	A	P	Gcc/Ccc	-2.24	0	0	probably_damaging	1	neutral	0.25	neutral	1.19	deleterious	-4.3	deleterious	-4.89	medium_impact	2.98	0.28	damaging	0.29	neutral	3.80	23.40	deleterious	0.18	0.45	NA	NA	0.87	disease	0.79	disease	0.72	disease	4	1	deleterious	0.13	neutral	1	deleterious	0.91	deleterious	-3.52	low_impact	-0.06	medium_impact	1.69	medium_impact	0.69	0.85	68.72	19.4	0.83	P	0.90	polymorphism	0.99	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8791	8791	C	G	MI.563	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	265	89	P	A	Cct/Gct	-7.28	0	0	probably_damaging	1	deleterious	0	neutral	2.15	deleterious	-6.18	deleterious	-7.13	high_impact	4.64	0.61	neutral	0.1	damaging	3.00	22.20	deleterious	0.19	0.65	0.86	disease	0.48	neutral	0.69	disease	0.66	disease	3	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-1.4	low_impact	2.88	high_impact	0.67	0.9	49.12	8.71	0.42	N	0.79	disease_causing	0.68	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7794	7794	C	T	MI.5630	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	209	70	A	V	gCc/gTc	9.29	1	0	probably_damaging	0.99	neutral	0.51	neutral	1.32	neutral	-0.35	deleterious	-3.9	medium_impact	2.17	0.35	damaging	0.32	neutral	4.39	24.10	deleterious	0.38	0.5	NA	NA	0.73	disease	0.51	disease	0.14	neutral	7	0.99	deleterious	0.26	neutral	1	deleterious	0.86	deleterious	-2.58	low_impact	0.21	medium_impact	0.93	medium_impact	0.75	0.85	68.72	19.4	0.78	P	0.79	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7794	7794	C	G	MI.5631	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	209	70	A	G	gCc/gGc	9.29	1	0	probably_damaging	0.98	neutral	0.33	neutral	1.2	deleterious	-3.11	deleterious	-3.94	medium_impact	2.98	0.37	damaging	0.48	neutral	3.89	23.50	deleterious	0.33	0.5	NA	NA	0.72	disease	0.65	disease	0.54	disease	1	0.99	deleterious	0.18	neutral	1	deleterious	0.81	deleterious	-2.3	low_impact	0.04	medium_impact	1.69	medium_impact	0.67	0.85	68.72	19.4	0.77	P	0.74	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7794	7794	C	A	MI.5632	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	209	70	A	D	gCc/gAc	9.29	1	0	probably_damaging	1	neutral	0.23	neutral	1.2	deleterious	-4.23	deleterious	-5.87	high_impact	4.26	0.34	damaging	0.3	neutral	4.47	24.20	deleterious	0.18	0.45	NA	NA	0.89	disease	0.77	disease	0.73	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.09	medium_impact	2.89	high_impact	0.58	0.8	68.72	19.4	0.8	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7796	7796	A	C	MI.5633	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	211	71	I	L	Atc/Ctc	-9.85	0	0	benign	0.06	neutral	0.43	neutral	1.61	neutral	0.12	neutral	-1.34	low_impact	1.15	0.75	neutral	0.78	neutral	0.61	8.22	deleterious	0.33	0.5	NA	NA	0.45	neutral	0.36	neutral	0.16	neutral	7	0.52	neutral	0.69	deleterious	-6	neutral	0.17	neutral	0.39	medium_impact	0.14	medium_impact	-0.03	medium_impact	0.52	0.8	66.52	14.61	0.38	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7796	7796	A	T	MI.5634	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	211	71	I	F	Atc/Ttc	-9.85	0	0	possibly_damaging	0.59	neutral	0.23	neutral	1.37	neutral	-1.42	deleterious	-2.69	low_impact	0.84	0.68	neutral	0.5	neutral	0.80	9.48	deleterious	0.36	0.5	NA	NA	0.51	disease	0.44	neutral	0.18	neutral	6	0.77	neutral	0.32	neutral	-3	neutral	0.55	deleterious	-0.87	medium_impact	-0.09	medium_impact	-0.32	medium_impact	0.59	0.8	66.52	14.61	0.35	N	0.83	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7796	7796	A	G	MI.5635	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	211	71	I	V	Atc/Gtc	-9.85	0	0	benign	0	neutral	0.45	neutral	1.6	neutral	0.05	neutral	-0.59	neutral_impact	0.39	0.84	neutral	0.87	neutral	-0.59	0.13	neutral	0.51	0.6	NA	NA	0.14	neutral	0.38	neutral	0.21	neutral	6	0.55	neutral	0.73	deleterious	-6	neutral	0.12	neutral	2.08	high_impact	0.16	medium_impact	-0.74	medium_impact	0.35	0.8	66.52	14.61	0.39	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7797	7797	T	A	MI.5636	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	212	71	I	N	aTc/aAc	0.06	0	0	probably_damaging	0.94	deleterious	0.03	neutral	1.24	deleterious	-5.2	deleterious	-5.82	high_impact	3.66	0.6	damaging	0.29	neutral	4.20	23.90	deleterious	0.23	0.45	NA	NA	0.74	disease	0.65	disease	0.68	disease	4	0.99	deleterious	0.05	neutral	6	deleterious	0.75	deleterious	-1.83	low_impact	-0.63	medium_impact	2.33	high_impact	0.56	0.8	66.52	14.61	0.3	N	0.95	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7797	7797	T	G	MI.5637	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	212	71	I	S	aTc/aGc	0.06	0	0	possibly_damaging	0.76	neutral	0.09	neutral	1.25	deleterious	-4.02	deleterious	-4.71	medium_impact	2.97	0.57	damaging	0.35	neutral	3.85	23.40	deleterious	0.27	0.45	NA	NA	0.76	disease	0.61	disease	0.67	disease	3	0.94	neutral	0.17	neutral	0	NA	0.56	deleterious	-1.19	low_impact	-0.35	medium_impact	1.68	medium_impact	0.42	0.8	66.52	14.61	0.32	N	0.84	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7797	7797	T	C	MI.5638	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	212	71	I	T	aTc/aCc	0.06	0	0	possibly_damaging	0.5	neutral	0.26	neutral	1.26	deleterious	-3.38	deleterious	-3.75	medium_impact	2.97	0.59	damaging	0.37	neutral	1.60	13.83	neutral	0.4	0.5	NA	NA	0.5	disease	0.6	disease	0.57	disease	1	0.72	neutral	0.38	neutral	0	NA	0.36	neutral	-0.72	medium_impact	-0.05	medium_impact	1.68	medium_impact	0.54	0.8	66.52	14.61	0.36	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7798	7798	C	A	MI.5639	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	213	71	I	M	atC/atA	3.06	0.17	0	possibly_damaging	0.76	neutral	0.07	neutral	1.3	neutral	-2.44	neutral	-2.04	low_impact	1.3	0.77	neutral	0.78	neutral	0.74	9.08	deleterious	0.38	0.5	NA	NA	0.3	neutral	0.41	neutral	0.16	neutral	7	0.95	neutral	0.16	neutral	-3	neutral	0.43	neutral	-1.19	low_impact	-0.42	medium_impact	0.11	medium_impact	0.64	0.8	66.52	14.61	0.41	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8791	8791	C	T	MI.564	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	265	89	P	S	Cct/Tct	-7.28	0	0	probably_damaging	1	deleterious	0.02	neutral	2.15	deleterious	-6.47	deleterious	-7.08	high_impact	4.09	0.6	damaging	0.07	damaging	3.81	23.40	deleterious	0.25	0.65	0.88	disease	0.7	disease	0.73	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-0.66	medium_impact	2.41	high_impact	0.42	0.9	49.12	8.71	0.27	N	0.82	disease_causing	0.78	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7798	7798	C	G	MI.5640	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	213	71	I	M	atC/atG	3.06	0.17	0	possibly_damaging	0.76	neutral	0.07	neutral	1.3	neutral	-2.44	neutral	-2.04	low_impact	1.3	0.77	neutral	0.78	neutral	0.21	4.83	deleterious	0.38	0.5	NA	NA	0.3	neutral	0.41	neutral	0.16	neutral	7	0.95	neutral	0.16	neutral	-3	neutral	0.43	neutral	-1.19	low_impact	-0.42	medium_impact	0.11	medium_impact	0.64	0.8	66.52	14.61	0.41	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7799	7799	A	G	MI.5641	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	214	72	I	V	Atc/Gtc	-6.16	0	0	probably_damaging	0.92	neutral	0.48	neutral	1.13	neutral	-1.71	neutral	-0.4	low_impact	1.64	0.71	neutral	0.54	neutral	1.56	13.63	neutral	0.45	0.55	NA	NA	0.14	neutral	0.46	neutral	0.2	neutral	6	0.92	neutral	0.28	neutral	-2	neutral	0.58	deleterious	-1.71	low_impact	0.19	medium_impact	0.43	medium_impact	0.46	0.8	68.28	19.06	0.37	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7799	7799	A	T	MI.5642	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	214	72	I	F	Atc/Ttc	-6.16	0	0	probably_damaging	1	neutral	0.21	neutral	0.91	deleterious	-4.62	deleterious	-3.73	medium_impact	2.68	0.37	damaging	0.06	damaging	3.71	23.30	deleterious	0.32	0.5	NA	NA	0.75	disease	0.63	disease	0.64	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.11	medium_impact	1.41	medium_impact	0.73	0.85	68.28	19.06	0.41	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7799	7799	A	C	MI.5643	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	214	72	I	L	Atc/Ctc	-6.16	0	0	probably_damaging	0.97	neutral	0.53	neutral	1.07	neutral	-2.14	neutral	-1.81	medium_impact	2.27	0.36	damaging	0.12	damaging	3.74	23.30	deleterious	0.29	0.45	NA	NA	0.62	disease	0.56	disease	0.47	neutral	1	0.97	neutral	0.28	neutral	1	deleterious	0.63	deleterious	-2.13	low_impact	0.23	medium_impact	1.02	medium_impact	0.57	0.8	68.28	19.06	0.46	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7800	7800	T	A	MI.5644	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	215	72	I	N	aTc/aAc	4.67	1	0	probably_damaging	1	neutral	0.19	neutral	0.89	deleterious	-6.14	deleterious	-6.07	high_impact	3.88	0.38	damaging	0.07	damaging	4.41	24.10	deleterious	0.17	0.45	NA	NA	0.79	disease	0.68	disease	0.66	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	-0.14	medium_impact	2.53	high_impact	0.55	0.8	68.28	19.06	0.59	P	0.99	disease_causing	0.83	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7800	7800	T	C	MI.5645	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	215	72	I	T	aTc/aCc	4.67	1	0	probably_damaging	1	neutral	0.52	neutral	0.98	deleterious	-3.06	deleterious	-3.62	low_impact	1.87	0.44	damaging	0.17	damaging	2.27	17.99	deleterious	0.38	0.5	NA	NA	0.23	neutral	0.5	neutral	0.16	neutral	7	1	deleterious	0.26	neutral	-2	neutral	0.71	deleterious	-3.52	low_impact	0.22	medium_impact	0.65	medium_impact	0.51	0.8	68.28	19.06	0.63	P	0.96	disease_causing	0.61	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7800	7800	T	G	MI.5646	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	215	72	I	S	aTc/aGc	4.67	1	0	probably_damaging	1	neutral	0.05	neutral	0.9	deleterious	-5.02	deleterious	-5.08	high_impact	4.23	0.37	damaging	0.1	damaging	4.25	23.90	deleterious	0.21	0.45	NA	NA	0.79	disease	0.65	disease	0.65	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	-0.5	medium_impact	2.86	high_impact	0.49	0.8	68.28	19.06	0.65	P	0.91	disease_causing	0.86	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7801	7801	C	A	MI.5647	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	216	72	I	M	atC/atA	5.6	1	0	probably_damaging	1	neutral	0.11	neutral	0.97	deleterious	-3.27	deleterious	-2.52	medium_impact	2.1	0.4	damaging	0.08	damaging	3.81	23.40	deleterious	0.37	0.5	NA	NA	0.52	disease	0.61	disease	0.56	disease	1	1	deleterious	0.06	neutral	1	deleterious	0.74	deleterious	-3.52	low_impact	-0.3	medium_impact	0.86	medium_impact	0.70	0.85	68.28	19.06	0.64	P	0.79	disease_causing	0.75	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7801	7801	C	G	MI.5648	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	216	72	I	M	atC/atG	5.6	1	0	probably_damaging	1	neutral	0.11	neutral	0.97	deleterious	-3.27	deleterious	-2.52	medium_impact	2.1	0.4	damaging	0.08	damaging	3.34	22.90	deleterious	0.37	0.5	NA	NA	0.52	disease	0.61	disease	0.56	disease	1	1	deleterious	0.06	neutral	1	deleterious	0.74	deleterious	-3.52	low_impact	-0.3	medium_impact	0.86	medium_impact	0.70	0.85	68.28	19.06	0.63	P	0.79	disease_causing	0.75	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7802	7802	C	A	MI.5649	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	217	73	L	M	Cta/Ata	-4.32	0	0	probably_damaging	1	neutral	0.06	neutral	0.34	deleterious	-5.4	neutral	-1.92	high_impact	3.68	0.25	damaging	0.2	damaging	3.58	23.20	deleterious	0.28	0.45	NA	NA	0.57	disease	0.58	disease	0.52	disease	0	1	deleterious	0.03	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	-0.46	medium_impact	2.35	high_impact	0.56	0.8	68.72	19.46	0.83	P	0.78	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8792	8792	C	T	MI.565	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	266	89	P	L	cCt/cTt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.13	deleterious	-7.26	deleterious	-9.02	high_impact	4.29	0.55	damaging	0.05	damaging	4.31	24.00	deleterious	0.21	0.65	0.95	disease	0.77	disease	0.72	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.58	high_impact	0.77	0.9	49.12	8.71	0.48	N	0.95	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7802	7802	C	G	MI.5650	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	217	73	L	V	Cta/Gta	-4.32	0	0	probably_damaging	0.99	neutral	0.16	neutral	0.5	deleterious	-3.2	deleterious	-2.94	high_impact	3.88	0.17	damaging	0.02	damaging	3.34	22.90	deleterious	0.27	0.45	NA	NA	0.65	disease	0.67	disease	0.65	disease	3	0.99	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-2.58	low_impact	-0.19	medium_impact	2.53	high_impact	0.46	0.8	68.72	19.46	0.71	P	0.66	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7803	7803	T	G	MI.5651	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	218	73	L	R	cTa/cGa	-0.17	0	0	probably_damaging	1	deleterious	0.02	neutral	0.3	deleterious	-7.94	deleterious	-5.91	high_impact	4.57	0.21	damaging	0.01	damaging	4.11	23.70	deleterious	0.13	0.4	NA	NA	0.87	disease	0.77	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.92	deleterious	-3.52	low_impact	-0.73	medium_impact	3.18	high_impact	0.36	0.8	68.72	19.46	0.72	P	0.99	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7803	7803	T	C	MI.5652	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	218	73	L	P	cTa/cCa	-0.17	0	0	probably_damaging	1	deleterious	0.04	neutral	0.3	deleterious	-7.67	deleterious	-6.91	high_impact	4.22	0.18	damaging	0.02	damaging	3.85	23.40	deleterious	0.14	0.4	NA	NA	0.8	disease	0.76	disease	0.68	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.90	deleterious	-3.52	low_impact	-0.56	medium_impact	2.85	high_impact	0.54	0.8	68.72	19.46	0.7	P	0.99	polymorphism	0.79	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7803	7803	T	A	MI.5653	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	218	73	L	Q	cTa/cAa	-0.17	0	0	probably_damaging	1	deleterious	0.01	neutral	0.3	deleterious	-7.68	deleterious	-5.9	high_impact	4.22	0.18	damaging	0.02	damaging	4.01	23.60	deleterious	0.14	0.4	NA	NA	0.78	disease	0.66	disease	0.66	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.52	low_impact	-0.9	medium_impact	2.85	high_impact	0.47	0.8	68.72	19.46	0.69	P	0.95	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7805	7805	G	T	MI.5654	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	220	74	V	F	Gtc/Ttc	-4.09	0	0.01	benign	0.33	neutral	0.15	neutral	1.37	neutral	-1.62	deleterious	-3.05	low_impact	1.28	0.56	damaging	0.56	neutral	2.07	16.68	deleterious	0.22	0.45	NA	NA	0.74	disease	0.54	disease	0.21	neutral	6	0.82	neutral	0.41	neutral	-6	neutral	0.44	deleterious	-0.43	medium_impact	-0.21	medium_impact	0.1	medium_impact	0.64	0.8	47.14	14.51	0.34	N	0.67	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7805	7805	G	A	MI.5655	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	220	74	V	I	Gtc/Atc	-4.09	0	0.01	benign	0	neutral	1	neutral	1.72	neutral	0.55	neutral	0.57	neutral_impact	-1.18	0.81	neutral	0.99	neutral	-1.10	0.01	neutral	0.46	0.55	NA	NA	0.05	neutral	0.29	neutral	0.12	neutral	8	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.08	high_impact	1.86	high_impact	-2.21	low_impact	0.67	0.85	47.14	14.51	0.35	N	0.00	polymorphism	1	0.01	rs879119797	.	.	.	.	.	COSM1138406	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7805	7805	G	C	MI.5656	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	220	74	V	L	Gtc/Ctc	-4.09	0	0.01	benign	0.02	neutral	0.61	neutral	1.56	neutral	-0.12	neutral	-1.19	neutral_impact	0.64	0.66	neutral	0.57	neutral	0.32	5.87	deleterious	0.35	0.5	NA	NA	0.4	neutral	0.37	neutral	0.13	neutral	7	0.36	neutral	0.8	deleterious	-6	neutral	0.16	neutral	0.86	medium_impact	0.31	medium_impact	-0.51	medium_impact	0.44	0.8	47.14	14.51	0.29	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7806	7806	T	G	MI.5657	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	221	74	V	G	gTc/gGc	1.91	0.92	0	benign	0.31	neutral	0.15	neutral	1.26	deleterious	-4.88	deleterious	-6.38	medium_impact	2.46	0.57	damaging	0.48	neutral	2.02	16.35	deleterious	0.17	0.45	NA	NA	0.68	disease	0.59	disease	0.68	disease	4	0.82	neutral	0.42	neutral	-3	neutral	0.31	neutral	-0.4	medium_impact	-0.21	medium_impact	1.2	medium_impact	0.50	0.8	47.14	14.51	0.42	N	0.94	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7806	7806	T	A	MI.5658	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	221	74	V	D	gTc/gAc	1.91	0.92	0	possibly_damaging	0.49	deleterious	0.01	neutral	1.25	deleterious	-5.82	deleterious	-5.51	medium_impact	3	0.53	damaging	0.4	neutral	3.00	22.20	deleterious	0.08	0.35	NA	NA	0.82	disease	0.72	disease	0.72	disease	4	0.99	deleterious	0.26	neutral	4	deleterious	0.52	deleterious	-0.7	medium_impact	-0.9	medium_impact	1.71	medium_impact	0.47	0.8	47.14	14.51	0.39	N	0.91	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7806	7806	T	C	MI.5659	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	221	74	V	A	gTc/gCc	1.91	0.92	0	benign	0.1	neutral	0.1	neutral	1.29	neutral	-2.93	deleterious	-3.5	medium_impact	2.03	0.64	neutral	0.66	neutral	1.69	14.33	neutral	0.32	0.5	NA	NA	0.44	neutral	0.57	disease	0.38	neutral	2	0.89	neutral	0.5	deleterious	-3	neutral	0.20	neutral	0.17	medium_impact	-0.32	medium_impact	0.8	medium_impact	0.38	0.8	47.14	14.51	0.46	N	0.66	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8792	8792	C	G	MI.566	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	266	89	P	R	cCt/cGt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.12	deleterious	-7.83	deleterious	-8.1	high_impact	4.64	0.61	neutral	0.06	damaging	3.54	23.10	deleterious	0.16	0.65	0.97	disease	0.8	disease	0.82	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.88	high_impact	0.63	0.9	49.12	8.71	0.56	P	0.65	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7808	7808	C	G	MI.5660	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	223	75	L	V	Ctc/Gtc	-5.7	0	0	probably_damaging	0.97	neutral	0.28	neutral	1.45	neutral	-0.07	neutral	-0.72	neutral_impact	0.77	0.75	neutral	0.77	neutral	1.73	14.57	neutral	0.41	0.5	NA	NA	0.51	disease	0.38	neutral	0.19	neutral	6	0.98	neutral	0.16	neutral	-2	neutral	0.76	deleterious	-2.13	low_impact	-0.02	medium_impact	-0.38	medium_impact	0.53	0.8	66.08	15.78	0.4	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7808	7808	C	A	MI.5661	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	223	75	L	I	Ctc/Atc	-5.7	0	0	probably_damaging	0.99	neutral	0.45	neutral	1.5	neutral	-0.45	neutral	-0.57	low_impact	1.22	0.69	neutral	0.66	neutral	2.86	21.70	deleterious	0.4	0.5	NA	NA	0.5	disease	0.35	neutral	0.18	neutral	6	0.99	deleterious	0.23	neutral	-2	neutral	0.76	deleterious	-2.58	low_impact	0.16	medium_impact	0.04	medium_impact	0.58	0.8	66.08	15.78	0.35	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7808	7808	C	T	MI.5662	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	223	75	L	F	Ctc/Ttc	-5.7	0	0	probably_damaging	1	neutral	0.5	neutral	1.49	neutral	-1.04	neutral	-2.04	neutral_impact	-0.2	0.74	neutral	0.65	neutral	1.91	15.66	deleterious	0.43	0.55	NA	NA	0.07	neutral	0.26	neutral	0.15	neutral	7	1	deleterious	0.25	neutral	-2	neutral	0.72	deleterious	-3.52	low_impact	0.21	medium_impact	-1.29	low_impact	0.54	0.8	66.08	15.78	0.31	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7809	7809	T	A	MI.5663	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	224	75	L	H	cTc/cAc	-2.71	0	0	probably_damaging	1	deleterious	0.03	neutral	1.33	deleterious	-4.21	deleterious	-4.42	medium_impact	2.77	0.6	damaging	0.44	neutral	4.06	23.70	deleterious	0.18	0.45	NA	NA	0.72	disease	0.67	disease	0.69	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.81	deleterious	-3.52	low_impact	-0.63	medium_impact	1.49	medium_impact	0.61	0.8	66.08	15.78	0.31	N	0.81	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7809	7809	T	C	MI.5664	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	224	75	L	P	cTc/cCc	-2.71	0	0	probably_damaging	1	neutral	0.08	neutral	1.33	deleterious	-4.26	deleterious	-4.32	medium_impact	3.11	0.55	damaging	0.31	neutral	3.84	23.40	deleterious	0.18	0.45	NA	NA	0.89	disease	0.7	disease	0.74	disease	5	1	deleterious	0.04	neutral	1	deleterious	0.89	deleterious	-3.52	low_impact	-0.38	medium_impact	1.81	medium_impact	0.56	0.8	66.08	15.78	0.3	N	0.95	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7809	7809	T	G	MI.5665	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	224	75	L	R	cTc/cGc	-2.71	0	0	probably_damaging	1	deleterious	0.02	neutral	1.34	deleterious	-3.67	deleterious	-3.86	medium_impact	3.11	0.55	damaging	0.35	neutral	4.12	23.80	deleterious	0.2	0.45	NA	NA	0.89	disease	0.71	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.90	deleterious	-3.52	low_impact	-0.73	medium_impact	1.81	medium_impact	0.64	0.8	66.08	15.78	0.3	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7811	7811	A	C	MI.5666	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	226	76	I	L	Atc/Ctc	-2.24	0	0	probably_damaging	0.98	neutral	0.51	neutral	1.53	neutral	-0.18	neutral	-1.68	low_impact	1.75	0.69	neutral	0.83	neutral	0.73	9.04	deleterious	0.35	0.5	NA	NA	0.63	disease	0.46	neutral	0.14	neutral	7	0.98	deleterious	0.27	neutral	-2	neutral	0.59	deleterious	-2.3	low_impact	0.21	medium_impact	0.54	medium_impact	0.48	0.8	69.16	19.08	0.32	N	0.71	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7811	7811	A	G	MI.5667	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	226	76	I	V	Atc/Gtc	-2.24	0	0	probably_damaging	0.95	neutral	0.36	neutral	1.16	neutral	-2.37	neutral	-0.89	medium_impact	2.83	0.56	damaging	0.45	neutral	0.11	3.71	deleterious	0.46	0.55	NA	NA	0.5	neutral	0.54	disease	0.2	neutral	6	0.96	neutral	0.21	neutral	1	deleterious	0.72	deleterious	-1.91	low_impact	0.07	medium_impact	1.55	medium_impact	0.33	0.8	69.16	19.08	0.43	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7811	7811	A	T	MI.5668	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	226	76	I	F	Atc/Ttc	-2.24	0	0	probably_damaging	1	deleterious	0.02	neutral	1.1	deleterious	-3.48	deleterious	-3.81	high_impact	3.72	0.49	damaging	0.28	damaging	3.59	23.20	deleterious	0.32	0.5	NA	NA	0.82	disease	0.73	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.52	low_impact	-0.73	medium_impact	2.38	high_impact	0.59	0.8	69.16	19.08	0.39	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7812	7812	T	A	MI.5669	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	227	76	I	N	aTc/aAc	5.6	1	0	probably_damaging	1	deleterious	0.01	neutral	1.05	deleterious	-5.9	deleterious	-6.74	high_impact	4.42	0.53	damaging	0.29	neutral	4.40	24.10	deleterious	0.24	0.45	NA	NA	0.83	disease	0.73	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-3.52	low_impact	-0.9	medium_impact	3.04	high_impact	0.37	0.8	69.16	19.08	0.48	N	0.99	disease_causing	0.99	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8792	8792	C	A	MI.567	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	266	89	P	H	cCt/cAt	7.3	1	0	probably_damaging	1	deleterious	0	neutral	2.11	deleterious	-8.99	deleterious	-8.1	high_impact	4.64	0.63	neutral	0.04	damaging	3.85	23.40	deleterious	0.21	0.65	0.98	disease	0.79	disease	0.82	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.88	high_impact	0.61	0.9	49.12	8.71	0.55	P	0.64	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7812	7812	T	G	MI.5670	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	227	76	I	S	aTc/aGc	5.6	1	0	probably_damaging	1	deleterious	0.01	neutral	1.06	deleterious	-5.13	deleterious	-5.75	high_impact	4.42	0.5	damaging	0.36	neutral	4.19	23.90	deleterious	0.29	0.45	NA	NA	0.85	disease	0.7	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.52	low_impact	-0.9	medium_impact	3.04	high_impact	0.30	0.8	69.16	19.08	0.49	P	0.91	disease_causing	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7812	7812	T	C	MI.5671	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	227	76	I	T	aTc/aCc	5.6	1	0	probably_damaging	1	neutral	0.05	neutral	1.07	deleterious	-4.45	deleterious	-4.7	high_impact	3.72	0.54	damaging	0.33	neutral	1.72	14.53	neutral	0.41	0.5	NA	NA	0.68	disease	0.67	disease	0.53	disease	1	1	deleterious	0.03	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	-0.5	medium_impact	2.38	high_impact	0.41	0.8	69.16	19.08	0.53	P	0.96	disease_causing	0.96	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7813	7813	C	G	MI.5672	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	228	76	I	M	atC/atG	5.83	1	0	probably_damaging	1	neutral	0.19	neutral	1.19	neutral	-2.08	deleterious	-2.7	medium_impact	2.81	0.61	neutral	0.37	neutral	3.25	22.80	deleterious	0.41	0.5	NA	NA	0.67	disease	0.65	disease	0.54	disease	1	1	deleterious	0.1	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.14	medium_impact	1.53	medium_impact	0.58	0.8	69.16	19.08	0.51	P	0.79	disease_causing	0.96	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7813	7813	C	A	MI.5673	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	228	76	I	M	atC/atA	5.83	1	0	probably_damaging	1	neutral	0.19	neutral	1.19	neutral	-2.08	deleterious	-2.7	medium_impact	2.81	0.61	neutral	0.37	neutral	3.74	23.30	deleterious	0.41	0.5	NA	NA	0.67	disease	0.65	disease	0.54	disease	1	1	deleterious	0.1	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.14	medium_impact	1.53	medium_impact	0.58	0.8	69.16	19.08	0.52	P	0.79	disease_causing	0.96	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7814	7814	G	C	MI.5674	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	229	77	A	P	Gcc/Ccc	-2.71	0	0	probably_damaging	1	neutral	0.14	neutral	0.59	deleterious	-6.24	deleterious	-4.96	high_impact	4.53	0.28	damaging	0.23	damaging	3.74	23.30	deleterious	0.15	0.4	NA	NA	0.87	disease	0.79	disease	0.7	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	-0.23	medium_impact	3.14	high_impact	0.59	0.8	68.72	19.49	0.83	P	0.90	disease_causing	0.97	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7814	7814	G	T	MI.5675	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	229	77	A	S	Gcc/Tcc	-2.71	0	0	probably_damaging	1	neutral	0.3	neutral	0.68	deleterious	-3.66	deleterious	-2.97	medium_impact	3.17	0.26	damaging	0.3	neutral	3.65	23.20	deleterious	0.42	0.55	NA	NA	0.8	disease	0.67	disease	0.66	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	0	medium_impact	1.87	medium_impact	0.62	0.8	68.72	19.49	0.84	P	0.71	disease_causing	0.78	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7814	7814	G	A	MI.5676	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	229	77	A	T	Gcc/Acc	-2.71	0	0	probably_damaging	1	neutral	0.39	neutral	0.63	deleterious	-4.63	deleterious	-3.94	medium_impact	3.43	0.29	damaging	0.25	damaging	4.18	23.80	deleterious	0.43	0.55	NA	NA	0.75	disease	0.62	disease	0.55	disease	1	1	deleterious	0.2	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	0.1	medium_impact	2.11	high_impact	0.72	0.85	68.72	19.49	0.77	P	0.72	disease_causing	0.89	0.22	.	.	.	.	.	.	COSM1155680	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7815	7815	C	A	MI.5677	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	230	77	A	D	gCc/gAc	5.13	1	0	probably_damaging	1	neutral	0.24	neutral	0.58	deleterious	-6.71	deleterious	-5.94	high_impact	4.53	0.32	damaging	0.25	damaging	4.48	24.20	deleterious	0.18	0.45	NA	NA	0.91	disease	0.78	disease	0.71	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.07	medium_impact	3.14	high_impact	0.39	0.8	68.72	19.49	0.77	P	0.94	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7815	7815	C	G	MI.5678	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	230	77	A	G	gCc/gGc	5.13	1	0	probably_damaging	0.99	neutral	0.25	neutral	0.73	deleterious	-3.06	deleterious	-3.96	medium_impact	2.81	0.29	damaging	0.38	neutral	3.93	23.50	deleterious	0.38	0.5	NA	NA	0.73	disease	0.61	disease	0.35	neutral	3	0.99	deleterious	0.13	neutral	1	deleterious	0.83	deleterious	-2.58	low_impact	-0.06	medium_impact	1.53	medium_impact	0.65	0.8	68.72	19.49	0.92	P	0.74	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7815	7815	C	T	MI.5679	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	230	77	A	V	gCc/gTc	5.13	1	0	probably_damaging	1	neutral	0.51	neutral	0.63	deleterious	-4.63	deleterious	-3.97	medium_impact	3.38	0.25	damaging	0.2	damaging	4.47	24.20	deleterious	0.41	0.5	NA	NA	0.85	disease	0.68	disease	0.7	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.89	deleterious	-3.52	low_impact	0.21	medium_impact	2.06	high_impact	0.74	0.85	68.72	19.49	0.92	P	0.79	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8794	8794	C	A	MI.568	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	268	90	H	N	Cac/Aac	-20	0	0.17	possibly_damaging	0.46	deleterious	0	neutral	4.38	neutral	-0.55	deleterious	-4.88	low_impact	1.18	0.83	neutral	0.47	neutral	2.29	18.12	deleterious	0.67	0.75	0.68	disease	0.54	disease	0.76	disease	0.73	disease	5	1	deleterious	0.27	neutral	1	deleterious	0.58	deleterious	-0.69	medium_impact	-1.4	low_impact	-0.09	medium_impact	0.63	0.9	23.45	16.35	0.39	N	0.75	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7817	7817	C	A	MI.5680	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	232	78	L	I	Ctc/Atc	-2.24	0	0	benign	0.18	neutral	0.44	neutral	1.39	neutral	-1.14	neutral	-1.95	low_impact	1.34	0.55	damaging	0.46	neutral	2.20	17.51	deleterious	0.47	0.55	NA	NA	0.5	disease	0.39	neutral	0.18	neutral	6	0.47	neutral	0.63	deleterious	-6	neutral	0.24	neutral	-0.11	medium_impact	0.15	medium_impact	0.15	medium_impact	0.58	0.8	67.84	18.28	0.39	N	0.63	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7817	7817	C	G	MI.5681	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	232	78	L	V	Ctc/Gtc	-2.24	0	0	benign	0.07	neutral	0.48	neutral	1.48	neutral	-0.51	deleterious	-2.93	medium_impact	2.04	0.48	damaging	0.33	neutral	1.48	13.22	neutral	0.48	0.55	NA	NA	0.56	disease	0.55	disease	0.22	neutral	6	0.46	neutral	0.71	deleterious	-3	neutral	0.24	neutral	0.33	medium_impact	0.19	medium_impact	0.81	medium_impact	0.50	0.8	67.84	18.28	0.35	N	0.66	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7817	7817	C	T	MI.5682	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	232	78	L	F	Ctc/Ttc	-2.24	0	0	benign	0.01	neutral	0.41	neutral	1.4	neutral	-1.09	deleterious	-3.88	low_impact	1.77	0.58	damaging	0.41	neutral	0.71	8.89	deleterious	0.48	0.55	NA	NA	0.36	neutral	0.42	neutral	0.15	neutral	7	0.58	neutral	0.7	deleterious	-6	neutral	0.20	neutral	1.14	medium_impact	0.12	medium_impact	0.55	medium_impact	0.64	0.8	67.84	18.28	0.39	N	0.91	polymorphism	0.95	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7818	7818	T	C	MI.5683	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	233	78	L	P	cTc/cCc	1.68	0.87	0.01	probably_damaging	0.92	neutral	0.35	neutral	1.22	deleterious	-4.77	deleterious	-6.9	high_impact	3.77	0.34	damaging	0.28	neutral	3.82	23.40	deleterious	0.18	0.45	NA	NA	0.87	disease	0.76	disease	0.72	disease	4	0.93	neutral	0.22	neutral	2	deleterious	0.85	deleterious	-1.71	low_impact	0.06	medium_impact	2.43	high_impact	0.49	0.8	67.84	18.28	0.62	P	0.99	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7818	7818	T	G	MI.5684	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	233	78	L	R	cTc/cGc	1.68	0.87	0.01	possibly_damaging	0.78	neutral	0.2	neutral	1.23	deleterious	-4.2	deleterious	-5.9	high_impact	4.11	0.35	damaging	0.24	damaging	3.97	23.60	deleterious	0.2	0.45	NA	NA	0.89	disease	0.77	disease	0.73	disease	5	0.87	neutral	0.21	neutral	1	deleterious	0.77	deleterious	-1.23	low_impact	-0.13	medium_impact	2.75	high_impact	0.46	0.8	67.84	18.28	0.66	P	0.99	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7818	7818	T	A	MI.5685	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	233	78	L	H	cTc/cAc	1.68	0.87	0.01	possibly_damaging	0.88	neutral	0.17	neutral	1.22	deleterious	-4.79	deleterious	-6.86	high_impact	4.11	0.41	damaging	0.29	neutral	3.98	23.60	deleterious	0.23	0.45	NA	NA	0.79	disease	0.74	disease	0.69	disease	4	0.94	neutral	0.15	neutral	1	deleterious	0.78	deleterious	-1.53	low_impact	-0.18	medium_impact	2.75	high_impact	0.57	0.8	67.84	18.28	0.59	P	0.94	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7820	7820	C	T	MI.5686	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	235	79	P	S	Cca/Tca	-20	0	0	probably_damaging	1	neutral	0.32	neutral	0.69	deleterious	-4.77	deleterious	-7.97	high_impact	4.02	0.11	damaging	0.03	damaging	3.82	23.40	deleterious	0.43	0.55	NA	NA	0.85	disease	0.72	disease	0.69	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.02	medium_impact	2.66	high_impact	0.18	0.8	68.28	19.19	0.5	P	0.94	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7820	7820	C	A	MI.5687	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	235	79	P	T	Cca/Aca	-20	0	0	probably_damaging	1	neutral	0.2	neutral	0.69	deleterious	-4.83	deleterious	-7.97	high_impact	4.57	0.1	damaging	0.02	damaging	3.61	23.20	deleterious	0.28	0.45	NA	NA	0.81	disease	0.72	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.13	medium_impact	3.18	high_impact	0.72	0.85	68.28	19.19	0.5	P	0.96	polymorphism	1	0.29	.	.	.	.	.	.	COSM1319392	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7820	7820	C	G	MI.5688	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	235	79	P	A	Cca/Gca	-20	0	0	probably_damaging	0.99	neutral	0.41	neutral	0.71	deleterious	-4.33	deleterious	-7.97	high_impact	4.57	0.14	damaging	0.11	damaging	3.01	22.30	deleterious	0.29	0.45	NA	NA	0.72	disease	0.71	disease	0.67	disease	3	0.99	deleterious	0.21	neutral	2	deleterious	0.84	deleterious	-2.58	low_impact	0.12	medium_impact	3.18	high_impact	0.62	0.8	68.28	19.19	0.52	P	0.90	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7821	7821	C	G	MI.5689	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	236	79	P	R	cCa/cGa	7.21	1	0	probably_damaging	1	neutral	0.13	neutral	0.68	deleterious	-5.26	deleterious	-8.96	high_impact	4.57	0.11	damaging	0.02	damaging	3.54	23.10	deleterious	0.21	0.45	NA	NA	0.92	disease	0.81	disease	0.73	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	-0.25	medium_impact	3.18	high_impact	0.65	0.8	68.28	19.19	0.82	P	0.85	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8794	8794	C	T	MI.569	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	268	90	H	Y	Cac/Tac	-20	0	0.17	benign	0	neutral	1	neutral	4.68	neutral	3.37	neutral	0.24	neutral_impact	-2.38	0.96	neutral	0.89	neutral	-0.94	0.02	neutral	0.7	0.75	0.43	neutral	0.06	neutral	0.52	disease	0.21	neutral	6	0	neutral	1	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	1.98	high_impact	-3.14	low_impact	0.39	0.9	23.45	16.35	0.44	N	0.04	polymorphism	1	0.03	rs2298007	.	.	.	.	.	COSM1138408	.	14.37	C8794T	Exercise Endurance / Coronary Atherosclerosis risk	+	-	Reported	2	N	P	N,P	neutral
chrM	7821	7821	C	A	MI.5690	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	236	79	P	Q	cCa/cAa	7.21	1	0	probably_damaging	1	neutral	0.15	neutral	0.67	deleterious	-5.38	deleterious	-7.97	high_impact	4.57	0.11	damaging	0.03	damaging	4.10	23.70	deleterious	0.2	0.45	NA	NA	0.87	disease	0.76	disease	0.71	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.21	medium_impact	3.18	high_impact	0.55	0.8	68.28	19.19	0.82	P	0.88	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7821	7821	C	T	MI.5691	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	236	79	P	L	cCa/cTa	7.21	1	0	probably_damaging	1	neutral	0.4	neutral	0.73	deleterious	-3.95	deleterious	-9.93	high_impact	4.22	0.09	damaging	0.03	damaging	4.35	24.10	deleterious	0.32	0.5	NA	NA	0.92	disease	0.69	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.11	medium_impact	2.85	high_impact	0.74	0.85	68.28	19.19	0.78	P	0.92	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7823	7823	T	A	MI.5692	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	238	80	S	T	Tcc/Acc	-12.16	0	0	benign	0.05	neutral	0.28	neutral	-0.21	deleterious	-6.35	deleterious	-2.99	high_impact	4.24	0.3	damaging	0.33	neutral	1.87	15.38	deleterious	0.38	0.5	NA	NA	0.67	disease	0.7	disease	0.67	disease	3	0.7	neutral	0.62	deleterious	-2	neutral	0.27	neutral	0.47	medium_impact	-0.02	medium_impact	2.87	high_impact	0.79	0.85	68.28	19.22	0.49	P	0.53	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7823	7823	T	C	MI.5693	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	238	80	S	P	Tcc/Ccc	-12.16	0	0	benign	0	neutral	0.16	neutral	-0.23	deleterious	-7.66	deleterious	-4.98	high_impact	4.58	0.31	damaging	0.31	neutral	1.99	16.17	deleterious	0.2	0.45	NA	NA	0.84	disease	0.81	disease	0.7	disease	4	0.84	neutral	0.58	deleterious	-2	neutral	0.32	neutral	2.08	high_impact	-0.19	medium_impact	3.19	high_impact	0.46	0.8	68.28	19.22	0.55	P	0.99	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7823	7823	T	G	MI.5694	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	238	80	S	A	Tcc/Gcc	-12.16	0	0	benign	0.07	neutral	0.36	neutral	-0.17	deleterious	-5.52	deleterious	-2.99	high_impact	4.58	0.32	damaging	0.39	neutral	1.81	15.04	deleterious	0.37	0.5	NA	NA	0.63	disease	0.7	disease	0.67	disease	3	0.6	neutral	0.65	deleterious	-2	neutral	0.27	neutral	0.33	medium_impact	0.07	medium_impact	3.19	high_impact	0.72	0.85	68.28	19.22	0.52	P	0.36	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7824	7824	C	G	MI.5695	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	239	80	S	C	tCc/tGc	7.44	1	0	possibly_damaging	0.81	neutral	0.08	neutral	-0.24	deleterious	-8.33	deleterious	-4.98	high_impact	4.58	0.3	damaging	0.3	neutral	3.40	23.00	deleterious	0.25	0.45	NA	NA	0.76	disease	0.7	disease	0.66	disease	3	0.95	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-1.31	low_impact	-0.38	medium_impact	3.19	high_impact	0.49	0.8	68.28	19.22	0.7	P	0.91	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7824	7824	C	T	MI.5696	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	239	80	S	F	tCc/tTc	7.44	1	0	possibly_damaging	0.88	neutral	0.36	neutral	-0.24	deleterious	-8.65	deleterious	-5.98	high_impact	4.58	0.3	damaging	0.25	damaging	4.10	23.70	deleterious	0.18	0.45	NA	NA	0.88	disease	0.74	disease	0.7	disease	4	0.89	neutral	0.24	neutral	1	deleterious	0.84	deleterious	-1.53	low_impact	0.07	medium_impact	3.19	high_impact	0.33	0.8	68.28	19.22	0.73	P	0.99	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7824	7824	C	A	MI.5697	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	239	80	S	Y	tCc/tAc	7.44	1	0	possibly_damaging	0.88	neutral	0.35	neutral	-0.24	deleterious	-8.81	deleterious	-5.98	high_impact	4.58	0.29	damaging	0.24	damaging	4.08	23.70	deleterious	0.18	0.45	NA	NA	0.85	disease	0.74	disease	0.7	disease	4	0.89	neutral	0.24	neutral	1	deleterious	0.82	deleterious	-1.53	low_impact	0.06	medium_impact	3.19	high_impact	0.68	0.85	68.28	19.22	0.85	P	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7826	7826	C	A	MI.5698	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	241	81	L	M	Cta/Ata	-14.47	0	0	probably_damaging	1	neutral	0.13	neutral	0.76	deleterious	-4.43	neutral	-1.96	medium_impact	3.17	0.17	damaging	0.06	damaging	3.72	23.30	deleterious	0.34	0.5	0.68	disease	0.63	disease	0.54	disease	0.48	neutral	0	1	deleterious	0.07	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	-0.25	medium_impact	1.87	medium_impact	0.69	0.85	67.84	19.51	0.61	P	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7826	7826	C	G	MI.5699	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	241	81	L	V	Cta/Gta	-14.47	0	0	probably_damaging	0.94	neutral	0.35	neutral	0.77	deleterious	-4.06	deleterious	-2.85	high_impact	3.67	0.14	damaging	0.02	damaging	3.36	22.90	deleterious	0.32	0.5	0.66	disease	0.69	disease	0.55	disease	0.48	neutral	0	0.95	neutral	0.21	neutral	2	deleterious	0.80	deleterious	-1.83	low_impact	0.06	medium_impact	2.34	high_impact	0.55	0.8	67.84	19.51	0.55	P	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8552	8552	T	A	MI.57	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	26	9	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.92	deleterious	0.02	neutral	3.95	neutral	-1.79	deleterious	-2.53	medium_impact	2.9	0.59	damaging	0.54	neutral	4.05	23.70	deleterious	0.35	0.65	0.81	disease	0.75	disease	0.82	disease	0.84	disease	7	0.99	deleterious	0.05	neutral	5	deleterious	0.80	deleterious	-1.76	low_impact	-0.66	medium_impact	1.39	medium_impact	0.46	0.9	49.56	8.77	0.64	P	0.89	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8794	8794	C	G	MI.570	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	268	90	H	D	Cac/Gac	-20	0	0.17	possibly_damaging	0.56	deleterious	0	neutral	4.37	neutral	-1.32	deleterious	-6.2	low_impact	1.1	0.81	neutral	0.39	neutral	3.47	23.10	deleterious	0.32	0.65	0.78	disease	0.55	disease	0.79	disease	0.71	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.67	deleterious	-0.86	medium_impact	-1.4	low_impact	-0.16	medium_impact	0.61	0.9	23.45	16.35	0.35	N	0.90	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7827	7827	T	A	MI.5700	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	242	81	L	Q	cTa/cAa	-0.86	0	0	probably_damaging	1	neutral	0.23	neutral	0.71	deleterious	-6.88	deleterious	-5.94	high_impact	4.37	0.14	damaging	0.02	damaging	4.00	23.60	deleterious	0.2	0.45	0.92	disease	0.81	disease	0.64	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.09	medium_impact	2.99	high_impact	0.67	0.85	67.84	19.51	0.74	P	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7827	7827	T	C	MI.5701	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	242	81	L	P	cTa/cCa	-0.86	0	0	probably_damaging	1	neutral	0.34	neutral	0.71	deleterious	-7.46	deleterious	-6.91	high_impact	4.37	0.14	damaging	0.02	damaging	3.85	23.40	deleterious	0.17	0.45	0.94	disease	0.84	disease	0.77	disease	0.67	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.05	medium_impact	2.99	high_impact	0.49	0.8	67.84	19.51	0.72	P	0.99	polymorphism	0.92	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7827	7827	T	G	MI.5702	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	242	81	L	R	cTa/cGa	-0.86	0	0	probably_damaging	1	neutral	0.19	neutral	0.71	deleterious	-6.99	deleterious	-5.94	high_impact	4.37	0.16	damaging	0.01	damaging	4.15	23.80	deleterious	0.16	0.45	0.93	disease	0.9	disease	0.75	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	-0.14	medium_impact	2.99	high_impact	0.56	0.8	67.84	19.51	0.77	P	0.99	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7829	7829	C	A	MI.5703	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	244	82	R	S	Cgc/Agc	-2.48	0	0	probably_damaging	0.98	neutral	0.79	neutral	1.52	neutral	-0.73	deleterious	-5.59	medium_impact	2.87	0.44	damaging	0.22	damaging	4.51	24.30	deleterious	0.24	0.45	0.25	neutral	0.86	disease	0.67	disease	0.68	disease	4	0.98	neutral	0.41	neutral	1	deleterious	0.76	deleterious	-2.3	low_impact	0.52	medium_impact	1.59	medium_impact	0.42	0.8	68.72	19.03	0.35	N	0.77	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7829	7829	C	T	MI.5704	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	244	82	R	C	Cgc/Tgc	-2.48	0	0	probably_damaging	1	neutral	0.06	neutral	1.4	deleterious	-4.94	deleterious	-7.66	high_impact	4.14	0.37	damaging	0.12	damaging	4.95	25.00	deleterious	0.26	0.45	0.79	disease	0.87	disease	0.72	disease	0.67	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.46	medium_impact	2.78	high_impact	0.72	0.85	68.72	19.03	0.52	P	1.00	polymorphism	0.88	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7829	7829	C	G	MI.5705	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	244	82	R	G	Cgc/Ggc	-2.48	0	0	probably_damaging	0.98	neutral	0.39	neutral	1.44	neutral	-1.67	deleterious	-6.66	high_impact	4.14	0.4	damaging	0.24	damaging	4.16	23.80	deleterious	0.24	0.45	0.46	neutral	0.82	disease	0.72	disease	0.68	disease	4	0.98	deleterious	0.21	neutral	2	deleterious	0.76	deleterious	-2.3	low_impact	0.1	medium_impact	2.78	high_impact	0.56	0.8	68.72	19.03	0.53	P	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7830	7830	G	C	MI.5706	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	245	82	R	P	cGc/cCc	2.37	0.74	0.01	probably_damaging	0.99	neutral	0.3	neutral	1.45	neutral	-2.47	deleterious	-6.58	medium_impact	3.1	0.36	damaging	0.14	damaging	4.19	23.80	deleterious	0.11	0.4	0.54	disease	0.91	disease	0.81	disease	0.73	disease	5	0.99	deleterious	0.16	neutral	1	deleterious	0.85	deleterious	-2.58	low_impact	0	medium_impact	1.8	medium_impact	0.46	0.8	68.72	19.03	0.64	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7830	7830	G	T	MI.5707	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	245	82	R	L	cGc/cTc	2.37	0.74	0.01	probably_damaging	0.96	neutral	0.39	neutral	1.44	neutral	-2.33	deleterious	-6.66	medium_impact	3.17	0.41	damaging	0.25	damaging	4.25	23.90	deleterious	0.36	0.5	0.46	neutral	0.93	disease	0.67	disease	0.71	disease	4	0.96	neutral	0.22	neutral	1	deleterious	0.80	deleterious	-2.01	low_impact	0.1	medium_impact	1.87	medium_impact	0.37	0.8	68.72	19.03	0.55	P	1.00	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7830	7830	G	A	MI.5708	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	245	82	R	H	cGc/cAc	2.37	0.74	0.01	probably_damaging	0.99	neutral	0.15	neutral	1.44	neutral	-2.07	deleterious	-4.66	low_impact	1.82	0.47	damaging	0.18	damaging	4.38	24.10	deleterious	0.45	0.55	0.43	neutral	0.79	disease	0.47	neutral	0.16	neutral	7	0.99	deleterious	0.08	neutral	-2	neutral	0.78	deleterious	-2.58	low_impact	-0.21	medium_impact	0.6	medium_impact	0.82	0.85	68.72	19.03	0.39	N	0.99	disease_causing	1	0.10	rs878897170	.	.	.	.	.	COSM488769	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7832	7832	A	G	MI.5709	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	247	83	I	V	Atc/Gtc	-2.01	0	0	benign	0.01	neutral	0.06	neutral	1.48	neutral	-0.55	neutral	-0.72	medium_impact	2.3	0.63	neutral	0.56	neutral	1.07	11.05	neutral	0.68	0.7	0.34	neutral	0.48	neutral	0.38	neutral	0.3	neutral	4	0.94	neutral	0.53	deleterious	-3	neutral	0.18	neutral	1.14	medium_impact	-0.46	medium_impact	1.05	medium_impact	0.49	0.8	68.28	19.24	0.51	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8795	8795	A	T	MI.571	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	269	90	H	L	cAc/cTc	1.52	0.91	0	benign	0.16	deleterious	0.01	neutral	4.51	neutral	2.21	deleterious	-5.94	neutral_impact	0.57	0.86	neutral	0.43	neutral	1.96	15.96	deleterious	0.41	0.65	0.27	neutral	0.52	disease	0.76	disease	0.71	disease	4	0.99	deleterious	0.43	neutral	-2	neutral	0.35	neutral	-0.07	medium_impact	-0.84	medium_impact	-0.61	medium_impact	0.29	0.9	23.45	16.35	0.33	N	0.91	polymorphism	0.92	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7832	7832	A	T	MI.5710	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	247	83	I	F	Atc/Ttc	-2.01	0	0	possibly_damaging	0.85	neutral	0.16	neutral	1.27	deleterious	-3.34	deleterious	-3.8	medium_impact	3.4	0.5	damaging	0.24	damaging	3.72	23.30	deleterious	0.47	0.55	0.53	disease	0.8	disease	0.57	disease	0.69	disease	4	0.92	neutral	0.16	neutral	0	NA	0.77	deleterious	-1.42	low_impact	-0.19	medium_impact	2.08	high_impact	0.71	0.85	68.28	19.24	0.35	N	0.92	polymorphism	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7832	7832	A	C	MI.5711	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	247	83	I	L	Atc/Ctc	-2.01	0	0	benign	0.21	neutral	1	neutral	2.06	neutral	1.47	neutral	-1.65	neutral_impact	-0.02	0.59	damaging	0.47	neutral	0.46	7.12	deleterious	0.44	0.55	0.19	neutral	0.21	neutral	0.26	neutral	0.35	neutral	3	0.21	neutral	0.9	deleterious	-6	neutral	0.16	neutral	-0.18	medium_impact	1.86	high_impact	-1.12	low_impact	0.59	0.8	68.28	19.24	0.32	N	0.70	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7833	7833	T	A	MI.5712	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	248	83	I	N	aTc/aAc	6.98	1	0	probably_damaging	1	deleterious	0.04	neutral	1.23	deleterious	-5.89	deleterious	-6.63	medium_impact	3.4	0.44	damaging	0.23	damaging	4.42	24.20	deleterious	0.38	0.5	0.64	disease	0.87	disease	0.66	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.84	deleterious	-3.52	low_impact	-0.56	medium_impact	2.08	high_impact	0.49	0.8	68.28	19.24	0.59	P	0.99	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7833	7833	T	C	MI.5713	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	248	83	I	T	aTc/aCc	6.98	1	0	probably_damaging	0.97	neutral	0.07	neutral	1.25	deleterious	-3.88	deleterious	-4.49	medium_impact	2.22	0.55	damaging	0.54	neutral	3.29	22.80	deleterious	0.6	0.65	0.46	neutral	0.67	disease	0.42	neutral	0.34	neutral	3	0.99	deleterious	0.05	neutral	1	deleterious	0.67	deleterious	-2.13	low_impact	-0.42	medium_impact	0.98	medium_impact	0.47	0.8	68.28	19.24	0.52	P	0.96	disease_causing	1	0.12	.	.	.	.	.	.	COSM6716198	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7833	7833	T	G	MI.5714	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	248	83	I	S	aTc/aGc	6.98	1	0	probably_damaging	0.99	neutral	0.25	neutral	1.24	deleterious	-4.81	deleterious	-5.64	medium_impact	2.54	0.49	damaging	0.32	neutral	4.26	23.90	deleterious	0.37	0.5	0.49	neutral	0.85	disease	0.65	disease	0.61	disease	2	0.99	deleterious	0.13	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	-0.06	medium_impact	1.28	medium_impact	0.44	0.8	68.28	19.24	0.48	N	0.91	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7834	7834	C	A	MI.5715	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	249	83	I	M	atC/atA	4.67	1	0	probably_damaging	0.93	neutral	0.05	neutral	1.28	neutral	-2.97	deleterious	-2.59	medium_impact	3.05	0.51	damaging	0.35	neutral	3.80	23.40	deleterious	0.61	0.65	0.53	disease	0.65	disease	0.56	disease	0.66	disease	3	0.99	deleterious	0.06	neutral	1	deleterious	0.54	deleterious	-1.77	low_impact	-0.5	medium_impact	1.75	medium_impact	0.73	0.85	68.28	19.24	0.54	P	0.77	disease_causing	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7834	7834	C	G	MI.5716	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	249	83	I	M	atC/atG	4.67	1	0	probably_damaging	0.93	neutral	0.05	neutral	1.28	neutral	-2.97	deleterious	-2.59	medium_impact	3.05	0.51	damaging	0.35	neutral	3.33	22.90	deleterious	0.61	0.65	0.53	disease	0.65	disease	0.56	disease	0.66	disease	3	0.99	deleterious	0.06	neutral	1	deleterious	0.54	deleterious	-1.77	low_impact	-0.5	medium_impact	1.75	medium_impact	0.73	0.85	68.28	19.24	0.54	P	0.77	disease_causing	0.97	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7835	7835	C	G	MI.5717	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	250	84	L	V	Ctt/Gtt	-4.78	0	0	probably_damaging	0.97	deleterious	0.04	neutral	0.74	deleterious	-3.51	deleterious	-2.99	high_impact	3.94	0.27	damaging	0.27	damaging	3.37	22.90	deleterious	0.42	0.55	0.5	disease	0.66	disease	0.7	disease	0.67	disease	3	0.99	deleterious	0.04	neutral	6	deleterious	0.72	deleterious	-2.13	low_impact	-0.56	medium_impact	2.59	high_impact	0.75	0.85	68.72	19.53	0.81	P	0.63	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7835	7835	C	T	MI.5718	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	250	84	L	F	Ctt/Ttt	-4.78	0	0	probably_damaging	1	neutral	0.14	neutral	0.68	deleterious	-4.54	deleterious	-3.98	high_impact	4.41	0.3	damaging	0.28	neutral	3.91	23.50	deleterious	0.4	0.5	0.54	disease	0.71	disease	0.58	disease	0.64	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.76	deleterious	-3.52	low_impact	-0.23	medium_impact	3.03	high_impact	0.67	0.85	68.72	19.53	0.6	P	0.91	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7835	7835	C	A	MI.5719	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	250	84	L	I	Ctt/Att	-4.78	0	0	probably_damaging	0.99	neutral	0.33	neutral	0.75	deleterious	-3.45	neutral	-1.99	medium_impact	3.14	0.28	damaging	0.42	neutral	4.08	23.70	deleterious	0.42	0.55	0.54	disease	0.59	disease	0.51	disease	0.22	neutral	6	0.99	deleterious	0.17	neutral	1	deleterious	0.72	deleterious	-2.58	low_impact	0.04	medium_impact	1.84	medium_impact	0.72	0.85	68.72	19.53	0.85	P	0.60	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8795	8795	A	C	MI.572	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	269	90	H	P	cAc/cCc	1.52	0.91	0	possibly_damaging	0.78	deleterious	0	neutral	4.38	neutral	-0.96	deleterious	-6.63	medium_impact	2.07	0.74	neutral	0.32	neutral	2.96	22.10	deleterious	0.34	0.65	0.73	disease	0.76	disease	0.74	disease	0.74	disease	5	1	deleterious	0.11	neutral	4	deleterious	0.77	deleterious	-1.28	low_impact	-1.4	low_impact	0.68	medium_impact	0.42	0.9	23.45	16.35	0.27	N	0.96	polymorphism	0.92	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7836	7836	T	A	MI.5720	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	251	84	L	H	cTt/cAt	0.98	0.43	0	probably_damaging	1	neutral	0.12	neutral	0.64	deleterious	-6.32	deleterious	-6.97	high_impact	4.75	0.28	damaging	0.25	damaging	4.03	23.60	deleterious	0.17	0.45	0.83	disease	0.82	disease	0.78	disease	0.69	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	-0.27	medium_impact	3.35	high_impact	0.64	0.8	68.72	19.53	0.89	P	0.94	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7836	7836	T	C	MI.5721	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	251	84	L	P	cTt/cCt	0.98	0.43	0	probably_damaging	1	deleterious	0.02	neutral	0.65	deleterious	-6.1	deleterious	-6.97	high_impact	4.75	0.29	damaging	0.25	damaging	3.73	23.30	deleterious	0.12	0.4	0.83	disease	0.81	disease	0.81	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.52	low_impact	-0.73	medium_impact	3.35	high_impact	0.49	0.8	68.72	19.53	0.88	P	0.99	polymorphism	0.64	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7836	7836	T	G	MI.5722	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	251	84	L	R	cTt/cGt	0.98	0.43	0	probably_damaging	1	neutral	0.05	neutral	0.65	deleterious	-5.58	deleterious	-5.97	high_impact	4.75	0.27	damaging	0.2	damaging	4.07	23.70	deleterious	0.13	0.4	0.75	disease	0.89	disease	0.81	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.5	medium_impact	3.35	high_impact	0.54	0.8	68.72	19.53	0.9	P	0.99	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7838	7838	T	A	MI.5723	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	253	85	Y	N	Tac/Aac	-16.08	0	0	probably_damaging	0.99	deleterious	0.03	neutral	1.12	deleterious	-4.2	deleterious	-8.96	high_impact	4.37	0.29	damaging	0.31	neutral	3.93	23.50	deleterious	0.4	0.5	0.65	disease	0.86	disease	0.79	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-2.58	low_impact	-0.63	medium_impact	2.99	high_impact	0.17	0.8	68.28	19.5	0.73	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7838	7838	T	G	MI.5724	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	253	85	Y	D	Tac/Gac	-16.08	0	0	probably_damaging	0.99	deleterious	0.02	neutral	1.12	deleterious	-4.05	deleterious	-9.96	high_impact	4.71	0.3	damaging	0.28	damaging	3.85	23.40	deleterious	0.25	0.45	0.69	disease	0.89	disease	0.85	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-2.58	low_impact	-0.73	medium_impact	3.31	high_impact	0.27	0.8	68.28	19.5	0.66	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7838	7838	T	C	MI.5725	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	253	85	Y	H	Tac/Cac	-16.08	0	0	probably_damaging	0.99	neutral	0.06	neutral	1.11	deleterious	-4.24	deleterious	-4.98	high_impact	4.16	0.27	damaging	0.28	neutral	3.47	23.00	deleterious	0.55	0.6	0.73	disease	0.84	disease	0.84	disease	0.74	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-2.58	low_impact	-0.46	medium_impact	2.8	high_impact	0.31	0.8	68.28	19.5	0.81	P	0.94	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7839	7839	A	G	MI.5726	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	254	85	Y	C	tAc/tGc	7.44	1	0	probably_damaging	1	deleterious	0.02	neutral	1.1	deleterious	-5.2	deleterious	-8.96	high_impact	4.37	0.26	damaging	0.24	damaging	3.49	23.10	deleterious	0.38	0.5	0.84	disease	0.86	disease	0.81	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.52	low_impact	-0.73	medium_impact	2.99	high_impact	0.11	0.8	68.28	19.5	0.9	P	0.96	disease_causing	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7839	7839	A	T	MI.5727	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	254	85	Y	F	tAc/tTc	7.44	1	0	probably_damaging	0.92	neutral	0.08	neutral	1.18	neutral	-2.58	deleterious	-3.98	medium_impact	2.66	0.29	damaging	0.29	neutral	3.29	22.80	deleterious	0.47	0.55	0.31	neutral	0.81	disease	0.66	disease	0.66	disease	3	0.98	neutral	0.08	neutral	1	deleterious	0.71	deleterious	-1.71	low_impact	-0.38	medium_impact	1.39	medium_impact	0.36	0.8	68.28	19.5	0.88	P	0.87	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7839	7839	A	C	MI.5728	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	254	85	Y	S	tAc/tCc	7.44	1	0	probably_damaging	0.99	neutral	0.1	neutral	1.14	deleterious	-3.43	deleterious	-8.96	high_impact	4.37	0.27	damaging	0.39	neutral	3.67	23.30	deleterious	0.29	0.45	0.36	neutral	0.88	disease	0.78	disease	0.69	disease	4	0.99	deleterious	0.06	neutral	2	deleterious	0.78	deleterious	-2.58	low_impact	-0.32	medium_impact	2.99	high_impact	0.23	0.8	68.28	19.5	0.91	P	0.99	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7841	7841	A	C	MI.5729	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	256	86	M	L	Ata/Cta	-4.09	0	0	benign	0	neutral	1	neutral	1.84	neutral	2.24	neutral	0.66	neutral_impact	-0.7	0.81	neutral	0.93	neutral	-1.44	0.00	neutral	0.6	0.65	0.32	neutral	0.19	neutral	0.21	neutral	0.36	neutral	3	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.08	high_impact	1.86	high_impact	-1.76	low_impact	0.55	0.8	27.75	43.33	0.33	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8795	8795	A	G	MI.573	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	269	90	H	R	cAc/cGc	1.52	0.91	0	benign	0.38	deleterious	0	neutral	4.39	neutral	-0.31	deleterious	-5.28	low_impact	1.73	0.81	neutral	0.4	neutral	1.32	12.35	neutral	0.61	0.7	0.65	disease	0.6	disease	0.75	disease	0.73	disease	5	1	deleterious	0.31	neutral	-2	neutral	0.58	deleterious	-0.55	medium_impact	-1.4	low_impact	0.39	medium_impact	0.46	0.9	23.45	16.35	0.32	N	0.86	polymorphism	0.98	0.18	.	.	.	.	.	.	.	.	.	A8795G	MILS protective factor	-	+	Reported	1	.	P	P	damaging
chrM	7841	7841	A	G	MI.5730	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	256	86	M	V	Ata/Gta	-4.09	0	0	benign	0	neutral	0.12	neutral	1.61	neutral	0.41	neutral	-1.66	low_impact	1.84	0.68	neutral	0.46	neutral	0.72	8.94	deleterious	0.62	0.65	0.26	neutral	0.57	disease	0.53	disease	0.59	disease	2	0.88	neutral	0.56	deleterious	-6	neutral	0.14	neutral	2.08	high_impact	-0.27	medium_impact	0.62	medium_impact	0.41	0.8	27.75	43.33	0.45	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7841	7841	A	T	MI.5731	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	256	86	M	L	Ata/Tta	-4.09	0	0	benign	0	neutral	1	neutral	1.84	neutral	2.24	neutral	0.66	neutral_impact	-0.7	0.81	neutral	0.93	neutral	-1.41	0.00	neutral	0.6	0.65	0.32	neutral	0.19	neutral	0.21	neutral	0.36	neutral	3	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.08	high_impact	1.86	high_impact	-1.76	low_impact	0.55	0.8	27.75	43.33	0.33	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7842	7842	T	A	MI.5732	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	257	86	M	K	aTa/aAa	0.75	0.11	0	benign	0	neutral	0.12	neutral	1.59	neutral	0.16	deleterious	-4.5	low_impact	1.56	0.58	damaging	0.38	neutral	2.09	16.78	deleterious	0.3	0.45	0.29	neutral	0.73	disease	0.74	disease	0.7	disease	4	0.88	neutral	0.56	deleterious	-6	neutral	0.20	neutral	2.08	high_impact	-0.27	medium_impact	0.36	medium_impact	0.55	0.8	27.75	43.33	0.41	N	0.96	polymorphism	0.92	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7842	7842	T	C	MI.5733	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	257	86	M	T	aTa/aCa	0.75	0.11	0	benign	0	neutral	0.07	neutral	1.58	neutral	-0.08	deleterious	-3.73	medium_impact	2.03	0.66	neutral	0.48	neutral	1.02	10.77	neutral	0.51	0.6	0.34	neutral	0.54	disease	0.56	disease	0.65	disease	3	0.93	neutral	0.54	deleterious	-3	neutral	0.17	neutral	2.08	high_impact	-0.42	medium_impact	0.8	medium_impact	0.19	0.8	27.75	43.33	0.49	N	0.85	polymorphism	0.99	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7843	7843	A	C	MI.5734	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	258	86	M	I	atA/atC	7.44	0.97	0	benign	0	neutral	0.2	neutral	1.6	neutral	0.31	neutral	-0.93	neutral_impact	0.5	0.74	neutral	0.59	neutral	1.48	13.19	neutral	0.59	0.65	0.3	neutral	0.47	neutral	0.32	neutral	0.34	neutral	3	0.8	neutral	0.6	deleterious	-6	neutral	0.15	neutral	2.08	high_impact	-0.13	medium_impact	-0.64	medium_impact	0.55	0.8	27.75	43.33	0.59	P	0.53	polymorphism	0.66	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7843	7843	A	T	MI.5735	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	258	86	M	I	atA/atT	7.44	0.97	0	benign	0	neutral	0.2	neutral	1.6	neutral	0.31	neutral	-0.93	neutral_impact	0.5	0.74	neutral	0.59	neutral	1.51	13.36	neutral	0.59	0.65	0.3	neutral	0.47	neutral	0.32	neutral	0.34	neutral	3	0.8	neutral	0.6	deleterious	-6	neutral	0.15	neutral	2.08	high_impact	-0.13	medium_impact	-0.64	medium_impact	0.55	0.8	27.75	43.33	0.57	P	0.53	polymorphism	0.66	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7844	7844	A	T	MI.5736	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	259	87	T	S	Aca/Tca	-1.09	0	0	benign	0.12	neutral	0.17	neutral	1.58	neutral	-0.09	neutral	-0.51	low_impact	1.08	0.69	neutral	0.72	neutral	1.31	12.32	neutral	0.46	0.55	0.34	neutral	0.31	neutral	0.33	neutral	0.45	neutral	1	0.81	neutral	0.53	deleterious	-6	neutral	0.22	neutral	0.09	medium_impact	-0.18	medium_impact	-0.09	medium_impact	0.59	0.8	29.52	66.93	0.51	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7844	7844	A	C	MI.5737	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	259	87	T	P	Aca/Cca	-1.09	0	0	benign	0.41	neutral	0.05	neutral	1.52	neutral	-1.56	neutral	-1.64	medium_impact	2.94	0.6	neutral	0.44	neutral	1.81	15.05	deleterious	0.17	0.45	0.71	disease	0.71	disease	0.67	disease	0.69	disease	4	0.94	neutral	0.32	neutral	-3	neutral	0.64	deleterious	-0.57	medium_impact	-0.5	medium_impact	1.65	medium_impact	0.51	0.8	29.52	66.93	0.34	N	0.62	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7844	7844	A	G	MI.5738	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	259	87	T	A	Aca/Gca	-1.09	0	0	benign	0.01	neutral	0.13	neutral	1.57	neutral	-0.27	neutral	-0.64	medium_impact	2.04	0.85	neutral	0.82	neutral	1.53	13.48	neutral	0.56	0.6	0.4	neutral	0.26	neutral	0.53	disease	0.46	neutral	1	0.87	neutral	0.56	deleterious	-3	neutral	0.14	neutral	1.14	medium_impact	-0.25	medium_impact	0.81	medium_impact	0.24	0.8	29.52	66.93	0.45	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7845	7845	C	A	MI.5739	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	260	87	T	K	aCa/aAa	8.59	1	0	benign	0.17	neutral	0.22	neutral	1.54	neutral	-1.09	neutral	-0.77	medium_impact	2.6	0.66	neutral	0.58	neutral	2.67	20.60	deleterious	0.31	0.45	0.37	neutral	0.53	disease	0.63	disease	0.67	disease	3	0.74	neutral	0.53	deleterious	-3	neutral	0.36	neutral	-0.08	medium_impact	-0.1	medium_impact	1.33	medium_impact	0.58	0.8	29.52	66.93	0.62	P	0.48	disease_causing	0.53	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8796	8796	C	A	MI.574	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	270	90	H	Q	caC/caA	6.84	0.98	0	possibly_damaging	0.6	deleterious	0	neutral	4.38	neutral	-0.43	deleterious	-4.75	medium_impact	2.07	0.85	neutral	0.4	neutral	3.38	22.90	deleterious	0.69	0.75	0.67	disease	0.41	neutral	0.76	disease	0.69	disease	4	1	deleterious	0.2	neutral	4	deleterious	0.57	deleterious	-0.92	medium_impact	-1.4	low_impact	0.68	medium_impact	0.63	0.9	23.45	16.35	0.55	P	0.76	polymorphism	0.82	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7845	7845	C	T	MI.5740	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	260	87	T	M	aCa/aTa	8.59	1	0	possibly_damaging	0.76	neutral	0.62	neutral	1.69	neutral	1.13	neutral	4.42	neutral_impact	-1.04	0.73	neutral	0.96	neutral	1.04	10.90	neutral	0.44	0.55	0.25	neutral	0.06	neutral	0.15	neutral	0.2	neutral	6	0.71	neutral	0.43	neutral	-3	neutral	0.50	deleterious	-1.19	low_impact	0.32	medium_impact	-2.08	low_impact	0.55	0.8	29.52	66.93	0.56	P	0.03	polymorphism	0.61	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7847	7847	G	T	MI.5741	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	262	88	D	Y	Gac/Tac	-0.17	0.7	0	probably_damaging	1	neutral	1	neutral	1.17	deleterious	-3.64	deleterious	-8.96	medium_impact	3.29	0.17	damaging	0.03	damaging	3.85	23.40	deleterious	0.28	0.45	0.79	disease	0.89	disease	0.74	disease	0.67	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.88	deleterious	-3.52	low_impact	1.86	high_impact	1.98	medium_impact	0.24	0.8	68.72	19.54	0.62	P	0.99	disease_causing	0.98	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7847	7847	G	A	MI.5742	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	262	88	D	N	Gac/Aac	-0.17	0.7	0	probably_damaging	0.98	neutral	0.25	neutral	1.22	neutral	-2.44	deleterious	-4.97	medium_impact	2.59	0.16	damaging	0.02	damaging	4.17	23.80	deleterious	0.75	0.8	0.55	disease	0.77	disease	0.56	disease	0.64	disease	3	0.98	deleterious	0.14	neutral	1	deleterious	0.80	deleterious	-2.3	low_impact	-0.06	medium_impact	1.32	medium_impact	0.63	0.8	68.72	19.54	0.84	P	0.99	disease_causing	0.86	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7847	7847	G	C	MI.5743	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	262	88	D	H	Gac/Cac	-0.17	0.7	0	probably_damaging	1	neutral	0.43	neutral	1.16	deleterious	-4.12	deleterious	-6.97	high_impact	3.72	0.13	damaging	0.02	damaging	3.63	23.20	deleterious	0.44	0.55	0.44	neutral	0.84	disease	0.74	disease	0.7	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.14	medium_impact	2.38	high_impact	0.39	0.8	68.72	19.54	0.75	P	0.98	disease_causing	0.97	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7848	7848	A	T	MI.5744	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	263	88	D	V	gAc/gTc	7.44	1	0	probably_damaging	1	neutral	0.69	neutral	1.14	deleterious	-5.18	deleterious	-8.96	high_impact	3.84	0.13	damaging	0.01	damaging	3.71	23.30	deleterious	0.36	0.5	0.68	disease	0.9	disease	0.7	disease	0.7	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.4	medium_impact	2.5	high_impact	0.21	0.8	68.72	19.54	0.75	P	0.99	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7848	7848	A	C	MI.5745	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	263	88	D	A	gAc/gCc	7.44	1	0	probably_damaging	0.99	neutral	0.55	neutral	1.19	neutral	-2.94	deleterious	-7.96	high_impact	4.53	0.25	damaging	0.11	damaging	3.61	23.20	deleterious	0.42	0.55	0.49	neutral	0.8	disease	0.7	disease	0.68	disease	4	0.99	deleterious	0.28	neutral	2	deleterious	0.80	deleterious	-2.58	low_impact	0.25	medium_impact	3.14	high_impact	0.44	0.8	68.72	19.54	0.79	P	0.97	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7848	7848	A	G	MI.5746	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	263	88	D	G	gAc/gGc	7.44	1	0	probably_damaging	0.99	neutral	0.26	neutral	1.24	neutral	-2.18	deleterious	-6.97	medium_impact	3.48	0.14	damaging	0.04	damaging	3.95	23.60	deleterious	0.4	0.5	0.57	disease	0.84	disease	0.7	disease	0.7	disease	4	0.99	deleterious	0.14	neutral	1	deleterious	0.80	deleterious	-2.58	low_impact	-0.05	medium_impact	2.16	high_impact	0.33	0.8	68.72	19.54	0.87	P	0.97	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7849	7849	C	G	MI.5747	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	264	88	D	E	gaC/gaG	6.98	1	0	possibly_damaging	0.9	neutral	0.42	neutral	1.38	neutral	-0.95	deleterious	-3.98	low_impact	1.63	0.17	damaging	0.05	damaging	3.80	23.40	deleterious	0.57	0.65	0.35	neutral	0.71	disease	0.33	neutral	0.17	neutral	7	0.9	neutral	0.26	neutral	-3	neutral	0.74	deleterious	-1.61	low_impact	0.13	medium_impact	0.42	medium_impact	0.53	0.8	68.72	19.54	0.84	P	0.95	disease_causing	1	0.12	rs386829015	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7849	7849	C	A	MI.5748	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	264	88	D	E	gaC/gaA	6.98	1	0	possibly_damaging	0.9	neutral	0.42	neutral	1.38	neutral	-0.95	deleterious	-3.98	low_impact	1.63	0.17	damaging	0.05	damaging	4.14	23.80	deleterious	0.57	0.65	0.35	neutral	0.71	disease	0.33	neutral	0.17	neutral	7	0.9	neutral	0.26	neutral	-3	neutral	0.74	deleterious	-1.61	low_impact	0.13	medium_impact	0.42	medium_impact	0.53	0.8	68.72	19.54	0.84	P	0.95	disease_causing	1	0.12	rs386829015	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7850	7850	G	A	MI.5749	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	265	89	E	K	Gag/Aag	-3.17	0	0	probably_damaging	0.9	neutral	0.35	neutral	0.76	deleterious	-4.34	deleterious	-3.98	high_impact	3.86	0.28	damaging	0.17	damaging	4.46	24.20	deleterious	0.48	0.55	0.35	neutral	0.86	disease	0.74	disease	0.69	disease	4	0.91	neutral	0.23	neutral	2	deleterious	0.77	deleterious	-1.61	low_impact	0.06	medium_impact	2.51	high_impact	0.68	0.85	68.28	19.18	0.74	P	0.99	disease_causing	0.89	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8796	8796	C	G	MI.575	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	270	90	H	Q	caC/caG	6.84	0.98	0	possibly_damaging	0.6	deleterious	0	neutral	4.38	neutral	-0.43	deleterious	-4.75	medium_impact	2.07	0.85	neutral	0.4	neutral	3.16	22.60	deleterious	0.69	0.75	0.67	disease	0.41	neutral	0.76	disease	0.69	disease	4	1	deleterious	0.2	neutral	4	deleterious	0.57	deleterious	-0.92	medium_impact	-1.4	low_impact	0.68	medium_impact	0.63	0.9	23.45	16.35	0.55	P	0.76	polymorphism	0.82	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7850	7850	G	C	MI.5750	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	265	89	E	Q	Gag/Cag	-3.17	0	0	probably_damaging	0.91	neutral	0.33	neutral	0.75	deleterious	-4.47	deleterious	-2.98	high_impact	4.11	0.27	damaging	0.37	neutral	3.35	22.90	deleterious	0.55	0.6	0.52	disease	0.74	disease	0.69	disease	0.66	disease	3	0.92	neutral	0.21	neutral	2	deleterious	0.76	deleterious	-1.66	low_impact	0.04	medium_impact	2.75	high_impact	0.77	0.85	68.28	19.18	0.83	P	0.75	disease_causing	0.65	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7851	7851	A	C	MI.5751	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	266	89	E	A	gAg/gCg	4.21	1	0	probably_damaging	0.93	neutral	0.57	neutral	0.75	deleterious	-4.53	deleterious	-5.96	high_impact	4.31	0.29	damaging	0.36	neutral	3.71	23.30	deleterious	0.44	0.55	0.45	neutral	0.71	disease	0.69	disease	0.66	disease	3	0.92	neutral	0.32	neutral	2	deleterious	0.74	deleterious	-1.77	low_impact	0.27	medium_impact	2.94	high_impact	0.70	0.85	68.28	19.18	0.85	P	0.67	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7851	7851	A	T	MI.5752	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	266	89	E	V	gAg/gTg	4.21	1	0	probably_damaging	0.94	neutral	0.49	neutral	0.71	deleterious	-6.29	deleterious	-6.96	high_impact	3.68	0.26	damaging	0.28	damaging	4.27	24.00	deleterious	0.36	0.5	0.7	disease	0.87	disease	0.71	disease	0.69	disease	4	0.94	neutral	0.28	neutral	2	deleterious	0.82	deleterious	-1.83	low_impact	0.2	medium_impact	2.35	high_impact	0.71	0.85	68.28	19.18	0.86	P	0.82	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7851	7851	A	G	MI.5753	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	266	89	E	G	gAg/gGg	4.21	1	0	probably_damaging	0.96	neutral	0.37	neutral	0.73	deleterious	-5.32	deleterious	-6.96	high_impact	3.76	0.24	damaging	0.43	neutral	4.29	24.00	deleterious	0.49	0.55	0.6	disease	0.78	disease	0.72	disease	0.67	disease	3	0.96	neutral	0.21	neutral	2	deleterious	0.78	deleterious	-2.01	low_impact	0.08	medium_impact	2.42	high_impact	0.55	0.8	68.28	19.18	0.9	P	0.64	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7852	7852	G	T	MI.5754	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	267	89	E	D	gaG/gaT	6.98	1	0	possibly_damaging	0.69	neutral	0.26	neutral	1.07	neutral	-1.52	deleterious	-2.98	medium_impact	2.48	0.29	damaging	0.3	neutral	3.75	23.30	deleterious	0.58	0.65	0.45	neutral	0.69	disease	0.51	disease	0.13	neutral	7	0.79	neutral	0.29	neutral	0	NA	0.60	deleterious	-1.04	low_impact	-0.05	medium_impact	1.22	medium_impact	0.81	0.85	68.28	19.18	0.91	P	0.82	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7852	7852	G	C	MI.5755	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	267	89	E	D	gaG/gaC	6.98	1	0	possibly_damaging	0.69	neutral	0.26	neutral	1.07	neutral	-1.52	deleterious	-2.98	medium_impact	2.48	0.29	damaging	0.3	neutral	3.59	23.20	deleterious	0.58	0.65	0.45	neutral	0.69	disease	0.51	disease	0.13	neutral	7	0.79	neutral	0.29	neutral	0	NA	0.60	deleterious	-1.04	low_impact	-0.05	medium_impact	1.22	medium_impact	0.81	0.85	68.28	19.18	0.91	P	0.82	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7853	7853	G	C	MI.5756	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	268	90	V	L	Gtc/Ctc	-0.17	0.28	0.11	benign	0.01	neutral	0.8	neutral	1.31	neutral	-1.69	neutral	-1.14	low_impact	1.42	0.71	neutral	0.68	neutral	0.55	7.80	deleterious	0.61	0.65	0.45	neutral	0.61	disease	0.23	neutral	0.2	neutral	6	0.18	neutral	0.9	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	0.54	medium_impact	0.23	medium_impact	0.66	0.8	25.11	28.78	0.29	N	0.46	polymorphism	1	0.02	rs386420037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7853	7853	G	T	MI.5757	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	268	90	V	F	Gtc/Ttc	-0.17	0.28	0.11	benign	0.15	neutral	0.46	neutral	1.21	deleterious	-3.54	deleterious	-2.86	low_impact	1.52	0.69	neutral	0.71	neutral	1.96	15.95	deleterious	0.21	0.45	0.65	disease	0.8	disease	0.45	neutral	0.55	disease	1	0.45	neutral	0.66	deleterious	-6	neutral	0.41	neutral	-0.02	medium_impact	0.17	medium_impact	0.32	medium_impact	0.57	0.8	25.11	28.78	0.25	N	0.72	polymorphism	0.96	0.06	rs386420037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7853	7853	G	A	MI.5758	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	268	90	V	I	Gtc/Atc	-0.17	0.28	0.11	benign	0	neutral	0.62	neutral	1.5	neutral	-0.38	neutral	0.52	neutral_impact	-0.22	0.85	neutral	0.99	neutral	-0.94	0.02	neutral	0.58	0.65	0.28	neutral	0.06	neutral	0.14	neutral	0.22	neutral	6	0.38	neutral	0.81	deleterious	-6	neutral	0.08	neutral	2.08	high_impact	0.32	medium_impact	-1.31	low_impact	0.64	0.8	25.11	28.78	0.42	N	0.00	polymorphism	1	0.00	rs386420037	.	.	.	.	.	COSM1155681	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7854	7854	T	A	MI.5759	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	269	90	V	D	gTc/gAc	0.75	0.37	0	benign	0.4	neutral	0.69	neutral	1.19	deleterious	-4.84	deleterious	-5.83	medium_impact	2.88	0.57	damaging	0.43	neutral	2.93	22.00	deleterious	0.26	0.45	0.69	disease	0.85	disease	0.6	disease	0.72	disease	4	0.31	neutral	0.65	deleterious	-3	neutral	0.55	deleterious	-0.56	medium_impact	0.4	medium_impact	1.6	medium_impact	0.47	0.8	25.11	28.78	0.27	N	0.92	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8797	8797	T	C	MI.576	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	271	91	S	P	Tca/Cca	-1.72	0	0	probably_damaging	0.99	deleterious	0.03	neutral	4.19	deleterious	-3.36	deleterious	-3.42	medium_impact	2.44	0.65	neutral	0.08	damaging	4.00	23.60	deleterious	0.22	0.65	0.77	disease	0.73	disease	0.54	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-2.65	low_impact	-0.56	medium_impact	0.99	medium_impact	0.78	0.9	20.35	20.41	0.22	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7854	7854	T	G	MI.5760	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	269	90	V	G	gTc/gGc	0.75	0.37	0	benign	0.23	neutral	0.61	neutral	1.2	deleterious	-4.35	deleterious	-6.52	medium_impact	2.88	0.59	damaging	0.52	neutral	2.21	17.57	deleterious	0.26	0.45	0.7	disease	0.75	disease	0.58	disease	0.67	disease	3	0.28	neutral	0.69	deleterious	-3	neutral	0.50	deleterious	-0.23	medium_impact	0.31	medium_impact	1.6	medium_impact	0.56	0.8	25.11	28.78	0.28	N	0.92	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7854	7854	T	C	MI.5761	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	269	90	V	A	gTc/gCc	0.75	0.37	0	benign	0.04	neutral	0.87	neutral	1.28	neutral	-2.08	deleterious	-3.66	medium_impact	2.42	0.7	neutral	0.68	neutral	1.69	14.35	neutral	0.57	0.65	0.35	neutral	0.5	disease	0.54	disease	0.59	disease	2	0.06	neutral	0.92	deleterious	-3	neutral	0.20	neutral	0.57	medium_impact	0.66	medium_impact	1.16	medium_impact	0.30	0.8	25.11	28.78	0.29	N	0.70	polymorphism	0.96	0.07	.	.	.	.	.	.	COSM1132233	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7856	7856	A	C	MI.5762	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	271	91	N	H	Aac/Cac	-9.16	0	0	probably_damaging	0.98	neutral	0.23	neutral	1.85	neutral	-1.99	deleterious	-3.79	medium_impact	2.1	0.55	damaging	0.31	neutral	3.06	22.40	deleterious	0.64	0.7	0.61	disease	0.66	disease	0.28	neutral	0.23	neutral	5	0.99	deleterious	0.13	neutral	1	deleterious	0.73	deleterious	-2.3	low_impact	-0.09	medium_impact	0.86	medium_impact	0.34	0.8	67.4	16.13	0.35	N	0.64	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7856	7856	A	T	MI.5763	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	271	91	N	Y	Aac/Tac	-9.16	0	0	probably_damaging	0.99	neutral	0.28	neutral	1.85	deleterious	-3.04	deleterious	-5.95	low_impact	1.34	0.66	neutral	0.65	neutral	2.65	20.50	deleterious	0.46	0.55	0.7	disease	0.76	disease	0.27	neutral	0.26	neutral	5	0.99	deleterious	0.15	neutral	-2	neutral	0.77	deleterious	-2.58	low_impact	-0.02	medium_impact	0.15	medium_impact	0.37	0.8	67.4	16.13	0.3	N	0.49	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7856	7856	A	G	MI.5764	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	271	91	N	D	Aac/Gac	-9.16	0	0	possibly_damaging	0.86	neutral	0.58	neutral	1.93	neutral	-0.7	deleterious	-3.53	low_impact	1.47	0.69	neutral	0.74	neutral	2.64	20.40	deleterious	0.72	0.75	0.22	neutral	0.69	disease	0.26	neutral	0.19	neutral	6	0.84	neutral	0.36	neutral	-3	neutral	0.62	deleterious	-1.46	low_impact	0.28	medium_impact	0.27	medium_impact	0.55	0.8	67.4	16.13	0.31	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7857	7857	A	T	MI.5765	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	272	91	N	I	aAc/aTc	2.14	0.73	0	probably_damaging	0.99	neutral	0.24	neutral	1.85	neutral	-1.64	deleterious	-6.94	low_impact	1.06	0.54	damaging	0.52	neutral	2.89	21.80	deleterious	0.42	0.55	0.51	disease	0.8	disease	0.24	neutral	0.2	neutral	6	0.99	deleterious	0.13	neutral	-2	neutral	0.73	deleterious	-2.58	low_impact	-0.07	medium_impact	-0.11	medium_impact	0.30	0.8	67.4	16.13	0.35	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7857	7857	A	G	MI.5766	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	272	91	N	S	aAc/aGc	2.14	0.73	0	possibly_damaging	0.69	neutral	0.76	neutral	1.92	neutral	0.21	deleterious	-3	neutral_impact	0.5	0.66	neutral	0.71	neutral	1.57	13.71	neutral	0.7	0.75	0.36	neutral	0.43	neutral	0.23	neutral	0.43	neutral	1	0.63	neutral	0.54	deleterious	-3	neutral	0.61	deleterious	-1.04	low_impact	0.48	medium_impact	-0.64	medium_impact	0.27	0.8	67.4	16.13	0.27	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7857	7857	A	C	MI.5767	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	272	91	N	T	aAc/aCc	2.14	0.73	0	probably_damaging	0.91	neutral	0.56	neutral	1.9	neutral	-0.49	deleterious	-4.17	low_impact	1.6	0.63	neutral	0.73	neutral	3.31	22.90	deleterious	0.6	0.65	0.44	neutral	0.67	disease	0.35	neutral	0.2	neutral	6	0.9	neutral	0.33	neutral	-2	neutral	0.67	deleterious	-1.66	low_impact	0.26	medium_impact	0.4	medium_impact	0.38	0.8	67.4	16.13	0.29	N	0.71	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7858	7858	C	A	MI.5768	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	273	91	N	K	aaC/aaA	3.98	0.77	0	probably_damaging	0.96	neutral	0.86	neutral	1.91	neutral	0.08	deleterious	-4.44	low_impact	0.99	0.46	damaging	0.32	neutral	4.44	24.20	deleterious	0.68	0.7	0.3	neutral	0.77	disease	0.41	neutral	0.38	neutral	2	0.96	neutral	0.45	neutral	-2	neutral	0.72	deleterious	-2.01	low_impact	0.64	medium_impact	-0.18	medium_impact	0.44	0.8	67.4	16.13	0.39	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7858	7858	C	G	MI.5769	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	273	91	N	K	aaC/aaG	3.98	0.77	0	probably_damaging	0.96	neutral	0.86	neutral	1.91	neutral	0.08	deleterious	-4.44	low_impact	0.99	0.46	damaging	0.32	neutral	3.97	23.60	deleterious	0.68	0.7	0.3	neutral	0.77	disease	0.41	neutral	0.38	neutral	2	0.96	neutral	0.45	neutral	-2	neutral	0.72	deleterious	-2.01	low_impact	0.64	medium_impact	-0.18	medium_impact	0.44	0.8	67.4	16.13	0.38	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8797	8797	T	A	MI.577	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	271	91	S	T	Tca/Aca	-1.72	0	0	probably_damaging	0.98	neutral	1	neutral	4.25	neutral	-1.4	neutral	0	neutral_impact	-0.88	0.87	neutral	0.92	neutral	1.16	11.55	neutral	0.37	0.65	0.56	disease	0.03	neutral	0.16	neutral	0.33	neutral	3	0.98	neutral	0.51	deleterious	-2	neutral	0.66	deleterious	-2.36	low_impact	1.98	high_impact	-1.85	low_impact	0.75	0.9	20.35	20.41	0.37	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7859	7859	G	A	MI.5770	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	274	92	D	N	Gat/Aat	-5.24	0	0.01	benign	0	neutral	0.4	neutral	2.01	neutral	0.05	neutral	0.64	neutral_impact	-0.33	0.9	neutral	0.99	neutral	-0.35	0.50	neutral	0.82	0.85	0.45	neutral	0.13	neutral	0.16	neutral	0.26	neutral	5	0.6	neutral	0.7	deleterious	-6	neutral	0.12	neutral	2.08	high_impact	0.11	medium_impact	-1.42	low_impact	0.61	0.8	29.52	32.33	0.63	P	0.00	polymorphism	1	0.00	rs373105186	.	.	.	.	.	.	.	.	G7859A	Progressive Encephalomyopathy	+	-	Reported	1	N	P	N,P	neutral
chrM	7859	7859	G	T	MI.5771	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	274	92	D	Y	Gat/Tat	-5.24	0	0.01	possibly_damaging	0.76	neutral	1	neutral	1.78	deleterious	-3.55	deleterious	-4.47	medium_impact	2.14	0.62	neutral	0.48	neutral	3.60	23.20	deleterious	0.36	0.5	0.91	disease	0.72	disease	0.59	disease	0.68	disease	4	0.76	neutral	0.62	deleterious	0	NA	0.74	deleterious	-1.19	low_impact	1.86	high_impact	0.9	medium_impact	0.29	0.8	29.52	32.33	0.19	N	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7859	7859	G	C	MI.5772	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	274	92	D	H	Gat/Cat	-5.24	0	0.01	possibly_damaging	0.61	neutral	0.54	neutral	1.8	neutral	-2.77	neutral	-2.38	medium_impact	2.09	0.64	neutral	0.45	neutral	3.20	22.70	deleterious	0.56	0.6	0.84	disease	0.55	disease	0.36	neutral	0.48	neutral	0	0.57	neutral	0.47	neutral	0	NA	0.60	deleterious	-0.9	medium_impact	0.24	medium_impact	0.85	medium_impact	0.61	0.8	29.52	32.33	0.21	N	0.39	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7860	7860	A	G	MI.5773	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	275	92	D	G	gAt/gGt	0.52	0.16	0	benign	0.12	neutral	0.35	neutral	1.86	neutral	-1.36	deleterious	-2.65	medium_impact	2.14	0.56	damaging	0.51	neutral	2.24	17.75	deleterious	0.54	0.6	0.79	disease	0.65	disease	0.57	disease	0.67	disease	3	0.6	neutral	0.62	deleterious	-3	neutral	0.31	neutral	0.09	medium_impact	0.06	medium_impact	0.9	medium_impact	0.32	0.8	29.52	32.33	0.28	N	0.41	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7860	7860	A	C	MI.5774	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	275	92	D	A	gAt/gCt	0.52	0.16	0	benign	0.17	neutral	0.53	neutral	1.84	neutral	-1.7	deleterious	-3.4	medium_impact	2.09	0.64	neutral	0.67	neutral	1.79	14.94	neutral	0.5	0.6	0.69	disease	0.55	disease	0.56	disease	0.65	disease	3	0.37	neutral	0.68	deleterious	-3	neutral	0.40	neutral	-0.08	medium_impact	0.23	medium_impact	0.85	medium_impact	0.50	0.8	29.52	32.33	0.28	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7860	7860	A	T	MI.5775	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	275	92	D	V	gAt/gTt	0.52	0.16	0	possibly_damaging	0.53	neutral	0.53	neutral	1.78	deleterious	-3.5	deleterious	-4.74	medium_impact	2.35	0.6	damaging	0.51	neutral	2.33	18.33	deleterious	0.4	0.5	0.86	disease	0.72	disease	0.55	disease	0.65	disease	3	0.5	neutral	0.5	deleterious	0	NA	0.64	deleterious	-0.77	medium_impact	0.23	medium_impact	1.1	medium_impact	0.32	0.8	29.52	32.33	0.26	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7861	7861	T	A	MI.5776	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	276	92	D	E	gaT/gaA	3.75	0.94	0.01	benign	0.12	neutral	0.33	neutral	1.93	neutral	-0.51	neutral	-1.43	neutral_impact	0.44	0.72	neutral	0.79	neutral	0.75	9.17	deleterious	0.65	0.7	0.27	neutral	0.4	neutral	0.22	neutral	0.45	neutral	1	0.62	neutral	0.61	deleterious	-6	neutral	0.23	neutral	0.09	medium_impact	0.04	medium_impact	-0.69	medium_impact	0.59	0.8	29.52	32.33	0.49	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7861	7861	T	G	MI.5777	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	276	92	D	E	gaT/gaG	3.75	0.94	0.01	benign	0.12	neutral	0.33	neutral	1.93	neutral	-0.51	neutral	-1.43	neutral_impact	0.44	0.72	neutral	0.79	neutral	0.62	8.29	deleterious	0.65	0.7	0.27	neutral	0.4	neutral	0.22	neutral	0.45	neutral	1	0.62	neutral	0.61	deleterious	-6	neutral	0.23	neutral	0.09	medium_impact	0.04	medium_impact	-0.69	medium_impact	0.59	0.8	29.52	32.33	0.49	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7862	7862	C	A	MI.5778	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	277	93	P	T	Ccc/Acc	0.29	0.94	0	probably_damaging	1	neutral	0.43	neutral	1.71	neutral	-2.68	deleterious	-7.65	medium_impact	3.25	0.13	damaging	0.02	damaging	3.85	23.40	deleterious	0.52	0.6	0.61	disease	0.84	disease	0.53	disease	0.68	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.14	medium_impact	1.94	medium_impact	0.74	0.85	68.28	19.42	0.74	P	0.96	polymorphism	0.67	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7862	7862	C	T	MI.5779	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	277	93	P	S	Ccc/Tcc	0.29	0.94	0	probably_damaging	1	neutral	0.49	neutral	1.75	neutral	-1.87	deleterious	-7.61	medium_impact	2.81	0.11	damaging	0.03	damaging	3.87	23.50	deleterious	0.67	0.7	0.51	disease	0.82	disease	0.36	neutral	0.18	neutral	7	1	deleterious	0.25	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	0.2	medium_impact	1.53	medium_impact	0.20	0.8	68.28	19.42	0.65	P	0.91	polymorphism	0.66	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8797	8797	T	G	MI.578	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	271	91	S	A	Tca/Gca	-1.72	0	0	probably_damaging	0.97	neutral	0.19	neutral	4.29	neutral	-0.93	neutral	-1.8	low_impact	1.05	0.83	neutral	0.41	neutral	3.57	23.20	deleterious	0.41	0.65	0.59	disease	0.18	neutral	0.3	neutral	0.4	neutral	2	0.98	neutral	0.11	neutral	-2	neutral	0.71	deleterious	-2.19	low_impact	-0.06	medium_impact	-0.2	medium_impact	0.76	0.9	20.35	20.41	0.39	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7862	7862	C	G	MI.5780	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	277	93	P	A	Ccc/Gcc	0.29	0.94	0	probably_damaging	0.98	neutral	0.54	neutral	1.76	neutral	-1.73	deleterious	-7.51	medium_impact	2.29	0.2	damaging	0.16	damaging	3.07	22.40	deleterious	0.47	0.55	0.38	neutral	0.68	disease	0.55	disease	0.49	neutral	0	0.98	neutral	0.28	neutral	1	deleterious	0.72	deleterious	-2.3	low_impact	0.24	medium_impact	1.04	medium_impact	0.78	0.85	68.28	19.42	0.83	P	0.90	polymorphism	0.76	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7863	7863	C	T	MI.5781	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	278	93	P	L	cCc/cTc	3.52	1	0	probably_damaging	1	neutral	0.42	neutral	1.67	deleterious	-3.81	deleterious	-9.61	high_impact	4.01	0.1	damaging	0.02	damaging	4.44	24.20	deleterious	0.45	0.55	0.72	disease	0.87	disease	0.62	disease	0.68	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	0.13	medium_impact	2.65	high_impact	0.85	0.9	68.28	19.42	0.77	P	0.89	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7863	7863	C	G	MI.5782	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	278	93	P	R	cCc/cGc	3.52	1	0	probably_damaging	1	neutral	0.24	neutral	1.71	neutral	-2.65	deleterious	-8.65	high_impact	4.01	0.11	damaging	0.02	damaging	3.65	23.20	deleterious	0.47	0.55	0.61	disease	0.89	disease	0.73	disease	0.71	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	-0.07	medium_impact	2.65	high_impact	0.61	0.8	68.28	19.42	0.83	P	0.82	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7863	7863	C	A	MI.5783	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	278	93	P	H	cCc/cAc	3.52	1	0	probably_damaging	1	neutral	0.07	neutral	1.68	deleterious	-3.5	deleterious	-8.68	high_impact	4.22	0.11	damaging	0.02	damaging	4.06	23.70	deleterious	0.55	0.6	0.75	disease	0.86	disease	0.69	disease	0.68	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	-0.42	medium_impact	2.85	high_impact	0.62	0.8	68.28	19.42	0.84	P	0.79	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7865	7865	T	G	MI.5784	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	280	94	S	A	Tcc/Gcc	-16.08	0	0	possibly_damaging	0.9	neutral	0.53	neutral	2.05	neutral	0.85	neutral	-1.09	neutral_impact	0.76	0.73	neutral	0.86	neutral	0.58	8.03	deleterious	0.62	0.65	0.31	neutral	0.16	neutral	0.32	neutral	0.26	neutral	5	0.89	neutral	0.32	neutral	-3	neutral	0.53	deleterious	-1.61	low_impact	0.23	medium_impact	-0.39	medium_impact	0.71	0.85	24.67	37.99	0.35	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7865	7865	T	C	MI.5785	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	280	94	S	P	Tcc/Ccc	-16.08	0	0	probably_damaging	0.98	neutral	0.22	neutral	2.01	neutral	-0.98	neutral	-1.6	medium_impact	2.77	0.59	damaging	0.39	neutral	3.55	23.10	deleterious	0.45	0.55	0.54	disease	0.72	disease	0.3	neutral	0.4	neutral	2	0.98	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-2.3	low_impact	-0.1	medium_impact	1.49	medium_impact	0.59	0.8	24.67	37.99	0.37	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7865	7865	T	A	MI.5786	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	280	94	S	T	Tcc/Acc	-16.08	0	0	possibly_damaging	0.84	neutral	0.4	neutral	1.99	neutral	-0.35	neutral	-1.08	low_impact	1.44	0.76	neutral	0.97	neutral	0.66	8.54	deleterious	0.6	0.65	0.45	neutral	0.23	neutral	0.33	neutral	0.42	neutral	2	0.84	neutral	0.28	neutral	-3	neutral	0.59	deleterious	-1.39	low_impact	0.11	medium_impact	0.25	medium_impact	0.87	0.9	24.67	37.99	0.42	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7866	7866	C	G	MI.5787	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	281	94	S	C	tCc/tGc	-0.4	0	0	probably_damaging	0.99	neutral	0.18	neutral	1.92	deleterious	-4.56	neutral	-2.09	medium_impact	2.35	0.58	damaging	0.79	neutral	2.23	17.71	deleterious	0.45	0.55	0.93	disease	0.53	disease	0.23	neutral	0.68	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.76	deleterious	-2.58	low_impact	-0.16	medium_impact	1.1	medium_impact	0.61	0.8	24.67	37.99	0.38	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7866	7866	C	A	MI.5788	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	281	94	S	Y	tCc/tAc	-0.4	0	0	probably_damaging	1	neutral	1	neutral	1.96	neutral	-2.74	neutral	1.46	low_impact	1.13	0.73	neutral	0.83	neutral	0.74	9.07	deleterious	0.44	0.55	0.86	disease	0.52	disease	0.22	neutral	0.5	neutral	0	1	deleterious	0.5	deleterious	-2	neutral	0.78	deleterious	-3.52	low_impact	1.86	high_impact	-0.05	medium_impact	0.71	0.85	24.67	37.99	0.24	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7866	7866	C	T	MI.5789	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	281	94	S	F	tCc/tTc	-0.4	0	0	probably_damaging	1	neutral	0.7	neutral	1.96	deleterious	-3.3	neutral	-0.62	low_impact	1.64	0.64	neutral	0.62	neutral	1.04	10.90	neutral	0.41	0.5	0.89	disease	0.55	disease	0.25	neutral	0.54	disease	1	1	deleterious	0.35	neutral	-2	neutral	0.78	deleterious	-3.52	low_impact	0.41	medium_impact	0.43	medium_impact	0.52	0.8	24.67	37.99	0.28	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8798	8798	C	G	MI.579	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	272	91	S	W	tCa/tGa	2.67	0.96	0	probably_damaging	1	deleterious	0.02	neutral	4.18	deleterious	-3.54	deleterious	-4.88	medium_impact	2.98	0.77	neutral	0.11	damaging	4.32	24.00	deleterious	0.17	0.65	0.96	disease	0.65	disease	0.63	disease	0.8	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-0.66	medium_impact	1.46	medium_impact	0.49	0.9	20.35	20.41	0.34	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7868	7868	C	A	MI.5790	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	283	95	L	I	Ctt/Att	-10.08	0	0	benign	0.14	neutral	0.41	neutral	1.93	neutral	-0.33	neutral	-1.55	low_impact	1.27	0.76	neutral	0.94	neutral	1.09	11.14	neutral	0.44	0.55	0.36	neutral	0.11	neutral	0.25	neutral	0.29	neutral	4	0.52	neutral	0.64	deleterious	-6	neutral	0.18	neutral	0.01	medium_impact	0.12	medium_impact	0.09	medium_impact	0.76	0.85	28.19	65.66	0.5	N	0.32	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7868	7868	C	G	MI.5791	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	283	95	L	V	Ctt/Gtt	-10.08	0	0	benign	0.06	neutral	0.25	neutral	2.03	neutral	0.12	neutral	-2.4	medium_impact	1.94	0.77	neutral	0.93	neutral	0.47	7.17	deleterious	0.42	0.55	0.59	disease	0.37	neutral	0.3	neutral	0.61	disease	2	0.73	neutral	0.6	deleterious	-3	neutral	0.21	neutral	0.39	medium_impact	-0.06	medium_impact	0.71	medium_impact	0.52	0.8	28.19	65.66	0.39	N	0.35	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7868	7868	C	T	MI.5792	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	283	95	L	F	Ctt/Ttt	-10.08	0	0	benign	0	neutral	0.36	neutral	1.7	neutral	-2.52	deleterious	-3.52	medium_impact	2.49	0.68	neutral	0.84	neutral	2.01	16.26	deleterious	0.44	0.55	0.77	disease	0.57	disease	0.48	neutral	0.42	neutral	2	0.64	neutral	0.68	deleterious	-3	neutral	0.26	neutral	2.08	high_impact	0.07	medium_impact	1.23	medium_impact	0.67	0.85	28.19	65.66	0.36	N	0.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	C7868T	LHON	+	-	Possibly synergistic	1	.	N	N	damaging
chrM	7869	7869	T	C	MI.5793	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	284	95	L	P	cTt/cCt	-4.32	0	0	probably_damaging	0.99	neutral	0.27	neutral	1.64	deleterious	-5.12	deleterious	-6.49	medium_impact	3.4	0.33	damaging	0.33	neutral	3.88	23.50	deleterious	0.12	0.4	0.83	disease	0.84	disease	0.58	disease	0.67	disease	3	0.99	deleterious	0.14	neutral	1	deleterious	0.87	deleterious	-2.58	low_impact	-0.03	medium_impact	2.08	high_impact	0.43	0.8	28.19	65.66	0.52	P	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7869	7869	T	G	MI.5794	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	284	95	L	R	cTt/cGt	-4.32	0	0	probably_damaging	0.94	neutral	0.08	neutral	1.65	deleterious	-4.64	deleterious	-5.63	high_impact	4.09	0.36	damaging	0.31	neutral	4.16	23.80	deleterious	0.14	0.4	0.7	disease	0.84	disease	0.7	disease	0.71	disease	4	0.98	deleterious	0.07	neutral	2	deleterious	0.73	deleterious	-1.83	low_impact	-0.38	medium_impact	2.73	high_impact	0.61	0.8	28.19	65.66	0.54	P	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7869	7869	T	A	MI.5795	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	284	95	L	H	cTt/cAt	-4.32	0	0	probably_damaging	0.97	neutral	0.12	neutral	1.64	deleterious	-5.31	deleterious	-6.48	high_impact	4.09	0.46	damaging	0.4	neutral	4.08	23.70	deleterious	0.17	0.45	0.81	disease	0.73	disease	0.67	disease	0.69	disease	4	0.99	deleterious	0.08	neutral	2	deleterious	0.74	deleterious	-2.13	low_impact	-0.27	medium_impact	2.73	high_impact	0.55	0.8	28.19	65.66	0.37	N	0.82	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7871	7871	A	G	MI.5796	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	286	96	T	A	Acc/Gcc	-9.39	0	0	probably_damaging	0.98	neutral	0.22	neutral	1.76	neutral	-2.18	deleterious	-4.89	high_impact	3.63	0.22	damaging	0.13	damaging	3.53	23.10	deleterious	0.47	0.55	0.57	disease	0.58	disease	0.64	disease	0.63	disease	3	0.99	deleterious	0.12	neutral	2	deleterious	0.74	deleterious	-2.3	low_impact	-0.1	medium_impact	2.3	high_impact	0.39	0.8	68.72	19.4	0.75	P	0.65	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7871	7871	A	T	MI.5797	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	286	96	T	S	Acc/Tcc	-9.39	0	0	probably_damaging	0.98	neutral	0.78	neutral	1.77	neutral	-2.04	deleterious	-3.86	low_impact	1.75	0.18	damaging	0.06	damaging	3.31	22.90	deleterious	0.42	0.55	0.57	disease	0.49	neutral	0.42	neutral	0.24	neutral	5	0.98	deleterious	0.4	neutral	-2	neutral	0.76	deleterious	-2.3	low_impact	0.51	medium_impact	0.54	medium_impact	0.57	0.8	68.72	19.4	0.67	P	0.80	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7871	7871	A	C	MI.5798	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	286	96	T	P	Acc/Ccc	-9.39	0	0	probably_damaging	1	neutral	0.05	neutral	1.72	deleterious	-3.61	deleterious	-5.9	medium_impact	3.29	0.17	damaging	0.06	damaging	3.50	23.10	deleterious	0.15	0.4	0.35	neutral	0.76	disease	0.66	disease	0.65	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	-0.5	medium_impact	1.98	medium_impact	0.51	0.8	68.72	19.4	0.67	P	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7872	7872	C	A	MI.5799	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	287	96	T	N	aCc/aAc	6.98	1	0	probably_damaging	1	neutral	0.17	neutral	1.74	neutral	-2.37	deleterious	-4.88	medium_impact	2.17	0.14	damaging	0.04	damaging	3.64	23.20	deleterious	0.44	0.55	0.7	disease	0.78	disease	0.61	disease	0.66	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.18	medium_impact	0.93	medium_impact	0.68	0.85	68.72	19.4	0.88	P	0.87	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8552	8552	T	G	MI.58	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	26	9	F	C	tTc/tGc	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	3.82	deleterious	-4.53	deleterious	-7.02	medium_impact	3.24	0.58	damaging	0.54	neutral	3.85	23.40	deleterious	0.26	0.65	0.75	disease	0.83	disease	0.85	disease	0.85	disease	7	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-2.65	low_impact	-1.4	low_impact	1.68	medium_impact	0.21	0.9	49.56	8.77	0.58	P	1.00	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8798	8798	C	T	MI.580	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	272	91	S	L	tCa/tTa	2.67	0.96	0	probably_damaging	0.99	neutral	0.09	neutral	4.22	neutral	-2.06	deleterious	-3.89	low_impact	1.83	0.81	neutral	0.1	damaging	4.64	24.50	deleterious	0.34	0.65	0.76	disease	0.47	neutral	0.57	disease	0.67	disease	3	1	deleterious	0.05	neutral	-2	neutral	0.78	deleterious	-2.65	low_impact	-0.28	medium_impact	0.47	medium_impact	0.84	0.9	20.35	20.41	0.38	N	0.93	polymorphism	0.94	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7872	7872	C	G	MI.5800	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	287	96	T	S	aCc/aGc	6.98	1	0	probably_damaging	0.98	neutral	0.78	neutral	1.77	neutral	-2.04	deleterious	-3.86	low_impact	1.75	0.18	damaging	0.06	damaging	3.52	23.10	deleterious	0.42	0.55	0.57	disease	0.49	neutral	0.42	neutral	0.24	neutral	5	0.98	deleterious	0.4	neutral	-2	neutral	0.76	deleterious	-2.3	low_impact	0.51	medium_impact	0.54	medium_impact	0.57	0.8	68.72	19.4	0.82	P	0.80	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7872	7872	C	T	MI.5801	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	287	96	T	I	aCc/aTc	6.98	1	0	probably_damaging	1	neutral	0.28	neutral	1.76	deleterious	-3.39	deleterious	-5.92	high_impact	3.52	0.16	damaging	0.03	damaging	3.99	23.60	deleterious	0.33	0.5	0.56	disease	0.78	disease	0.62	disease	0.66	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.78	deleterious	-3.52	low_impact	-0.02	medium_impact	2.2	high_impact	0.63	0.8	68.72	19.4	0.85	P	0.77	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7874	7874	A	C	MI.5802	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	289	97	I	L	Atc/Ctc	-7.32	0	0	probably_damaging	0.97	neutral	1	neutral	1.67	neutral	-2.73	neutral	-1.4	low_impact	1.55	0.65	neutral	0.82	neutral	2.25	17.85	deleterious	0.24	0.45	0.55	disease	0.12	neutral	0.27	neutral	0.27	neutral	5	0.97	neutral	0.52	deleterious	-2	neutral	0.66	deleterious	-2.13	low_impact	1.86	high_impact	0.35	medium_impact	0.62	0.8	32.6	59.31	0.26	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7874	7874	A	T	MI.5803	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	289	97	I	F	Atc/Ttc	-7.32	0	0	probably_damaging	0.99	neutral	0.39	neutral	1.5	deleterious	-4.72	deleterious	-3.65	medium_impact	2.24	0.5	damaging	0.35	neutral	3.96	23.60	deleterious	0.15	0.4	0.49	neutral	0.65	disease	0.55	disease	0.56	disease	1	0.99	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-2.58	low_impact	0.1	medium_impact	1	medium_impact	0.71	0.85	32.6	59.31	0.33	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7874	7874	A	G	MI.5804	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	289	97	I	V	Atc/Gtc	-7.32	0	0	probably_damaging	0.97	neutral	0.46	neutral	1.96	neutral	-0.03	neutral	-0.44	neutral_impact	0.3	0.86	neutral	1	neutral	1.28	12.15	neutral	0.34	0.5	0.25	neutral	0.16	neutral	0.32	neutral	0.28	neutral	4	0.96	neutral	0.25	neutral	-2	neutral	0.60	deleterious	-2.13	low_impact	0.17	medium_impact	-0.82	medium_impact	0.59	0.8	32.6	59.31	0.34	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7875	7875	T	C	MI.5805	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	290	97	I	T	aTc/aCc	-0.17	0	0	probably_damaging	0.99	neutral	0.29	neutral	1.51	deleterious	-4.66	deleterious	-4.11	high_impact	3.56	0.59	damaging	0.33	neutral	3.46	23.00	deleterious	0.16	0.45	0.84	disease	0.57	disease	0.65	disease	0.58	disease	2	0.99	deleterious	0.15	neutral	2	deleterious	0.80	deleterious	-2.58	low_impact	-0.01	medium_impact	2.23	high_impact	0.43	0.8	32.6	59.31	0.31	N	0.77	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7875	7875	T	A	MI.5806	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	290	97	I	N	aTc/aAc	-0.17	0	0	probably_damaging	1	neutral	0.2	neutral	1.47	deleterious	-6.53	deleterious	-6.34	high_impact	3.9	0.5	damaging	0.31	neutral	4.46	24.20	deleterious	0.11	0.4	0.96	disease	0.8	disease	0.68	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.13	medium_impact	2.55	high_impact	0.31	0.8	32.6	59.31	0.34	N	0.98	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7875	7875	T	G	MI.5807	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	290	97	I	S	aTc/aGc	-0.17	0	0	probably_damaging	0.99	neutral	0.37	neutral	1.48	deleterious	-5.24	deleterious	-5.35	medium_impact	3.21	0.54	damaging	0.37	neutral	4.33	24.00	deleterious	0.11	0.4	0.92	disease	0.74	disease	0.67	disease	0.69	disease	4	0.99	deleterious	0.19	neutral	1	deleterious	0.85	deleterious	-2.58	low_impact	0.08	medium_impact	1.9	medium_impact	0.37	0.8	32.6	59.31	0.27	N	0.88	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7876	7876	C	G	MI.5808	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	291	97	I	M	atC/atG	5.83	0.94	0	probably_damaging	1	neutral	0.14	neutral	1.5	deleterious	-4.42	neutral	-2.15	medium_impact	2.55	0.66	neutral	0.57	neutral	3.28	22.80	deleterious	0.2	0.45	0.83	disease	0.33	neutral	0.37	neutral	0.64	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.76	deleterious	-3.52	low_impact	-0.23	medium_impact	1.29	medium_impact	0.68	0.85	32.6	59.31	0.54	P	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7876	7876	C	A	MI.5809	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	291	97	I	M	atC/atA	5.83	0.94	0	probably_damaging	1	neutral	0.14	neutral	1.5	deleterious	-4.42	neutral	-2.15	medium_impact	2.55	0.66	neutral	0.57	neutral	3.76	23.30	deleterious	0.2	0.45	0.83	disease	0.33	neutral	0.37	neutral	0.64	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.76	deleterious	-3.52	low_impact	-0.23	medium_impact	1.29	medium_impact	0.68	0.85	32.6	59.31	0.54	P	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8800	8800	T	A	MI.581	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	274	92	F	I	Ttt/Att	-3.34	0	0	probably_damaging	0.99	deleterious	0	neutral	4.12	neutral	-1.61	deleterious	-5.51	high_impact	3.71	0.58	damaging	0.1	damaging	4.36	24.10	deleterious	0.31	0.65	0.65	disease	0.72	disease	0.77	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.65	low_impact	-1.4	low_impact	2.08	high_impact	0.61	0.9	50	8.7	0.34	N	0.94	disease_causing	0.95	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7877	7877	A	C	MI.5810	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	292	98	K	Q	Aaa/Caa	-5.24	0	0	probably_damaging	1	neutral	0.25	neutral	1.71	neutral	-1.87	deleterious	-3.98	medium_impact	2.94	0.12	damaging	0.08	damaging	3.47	23.00	deleterious	0.28	0.45	0.59	disease	0.82	disease	0.65	disease	0.66	disease	3	1	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.06	medium_impact	1.65	medium_impact	0.69	0.85	68.72	19.61	0.83	P	0.90	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	A7877C	PEG glaucoma	+	-	Reported	1	.	P	P	damaging
chrM	7877	7877	A	G	MI.5811	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	292	98	K	E	Aaa/Gaa	-5.24	0	0	probably_damaging	1	neutral	0.45	neutral	1.81	neutral	-0.45	deleterious	-3.98	medium_impact	2.99	0.11	damaging	0.05	damaging	4.07	23.70	deleterious	0.24	0.45	0.41	neutral	0.88	disease	0.77	disease	0.69	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	0.16	medium_impact	1.7	medium_impact	0.77	0.85	68.72	19.61	0.81	P	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7878	7878	A	T	MI.5812	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	293	98	K	M	aAa/aTa	6.98	1	0	probably_damaging	1	neutral	0.07	neutral	1.62	deleterious	-4.26	deleterious	-5.97	high_impact	3.75	0.13	damaging	0.04	damaging	4.00	23.60	deleterious	0.15	0.4	0.84	disease	0.82	disease	0.73	disease	0.64	disease	3	1	deleterious	0.04	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	-0.42	medium_impact	2.41	high_impact	0.43	0.8	68.72	19.61	0.9	P	0.75	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7878	7878	A	C	MI.5813	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	293	98	K	T	aAa/aCa	6.98	1	0	probably_damaging	1	neutral	0.3	neutral	1.68	neutral	-2.32	deleterious	-5.97	medium_impact	3.06	0.12	damaging	0.04	damaging	3.73	23.30	deleterious	0.16	0.45	0.63	disease	0.87	disease	0.72	disease	0.68	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	0	medium_impact	1.76	medium_impact	0.52	0.8	68.72	19.61	0.89	P	0.88	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7879	7879	A	T	MI.5814	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	294	98	K	N	aaA/aaT	8.59	1	0.01	probably_damaging	1	neutral	0.21	neutral	1.7	neutral	-2.21	deleterious	-4.98	high_impact	3.52	0.11	damaging	0.03	damaging	3.95	23.60	deleterious	0.33	0.5	0.44	neutral	0.85	disease	0.73	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	-0.11	medium_impact	2.2	high_impact	0.64	0.8	68.72	19.61	0.91	P	0.84	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7879	7879	A	C	MI.5815	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	294	98	K	N	aaA/aaC	8.59	1	0.01	probably_damaging	1	neutral	0.21	neutral	1.7	neutral	-2.21	deleterious	-4.98	high_impact	3.52	0.11	damaging	0.03	damaging	3.85	23.40	deleterious	0.33	0.5	0.44	neutral	0.85	disease	0.73	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	-0.11	medium_impact	2.2	high_impact	0.64	0.8	68.72	19.61	0.91	P	0.84	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7880	7880	T	C	MI.5816	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	295	99	S	P	Tca/Cca	1.68	1	0	possibly_damaging	0.46	neutral	0.23	neutral	1.96	neutral	-1.49	neutral	-2.04	medium_impact	2.38	0.49	damaging	0.39	neutral	2.49	19.42	deleterious	0.12	0.4	0.68	disease	0.85	disease	0.58	disease	0.73	disease	5	0.74	neutral	0.39	neutral	0	NA	0.46	deleterious	-0.66	medium_impact	-0.09	medium_impact	1.13	medium_impact	0.63	0.8	32.16	66.63	0.51	N	0.68	polymorphism	0.9	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7880	7880	T	A	MI.5817	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	295	99	S	T	Tca/Aca	1.68	1	0	benign	0.14	neutral	0.74	neutral	2.03	neutral	0.16	neutral	0.64	neutral_impact	-0.66	0.76	neutral	0.96	neutral	0.42	6.81	deleterious	0.25	0.45	0.32	neutral	0.08	neutral	0.19	neutral	0.24	neutral	5	0.14	neutral	0.8	deleterious	-6	neutral	0.16	neutral	0.01	medium_impact	0.46	medium_impact	-1.72	low_impact	0.77	0.85	32.16	66.63	0.44	N	0.00	polymorphism	0.98	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7880	7880	T	G	MI.5818	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	295	99	S	A	Tca/Gca	1.68	1	0	benign	0	neutral	0.68	neutral	2.17	neutral	2.05	neutral	1.41	neutral_impact	-1.09	0.81	neutral	0.86	neutral	-0.87	0.03	neutral	0.24	0.45	0.41	neutral	0.11	neutral	0.2	neutral	0.25	neutral	5	0.31	neutral	0.84	deleterious	-6	neutral	0.13	neutral	2.08	high_impact	0.39	medium_impact	-2.13	low_impact	0.72	0.85	32.16	66.63	0.4	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7881	7881	C	T	MI.5819	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	296	99	S	L	tCa/tTa	1.91	1	0	benign	0.2	neutral	0.81	neutral	2.05	neutral	1.09	neutral	-1.99	low_impact	1.57	0.59	damaging	0.54	neutral	2.82	21.50	deleterious	0.15	0.4	0.35	neutral	0.69	disease	0.57	disease	0.69	disease	4	0.11	neutral	0.81	deleterious	-6	neutral	0.25	neutral	-0.16	medium_impact	0.55	medium_impact	0.37	medium_impact	0.75	0.85	32.16	66.63	0.36	N	0.66	polymorphism	0.93	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8800	8800	T	C	MI.582	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	274	92	F	L	Ttt/Ctt	-3.34	0	0	probably_damaging	0.98	deleterious	0.02	neutral	4.19	neutral	-1.01	deleterious	-5.51	high_impact	3.54	0.56	damaging	0.06	damaging	3.98	23.60	deleterious	0.44	0.65	0.68	disease	0.69	disease	0.75	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.36	low_impact	-0.66	medium_impact	1.94	medium_impact	0.64	0.9	50	8.7	0.29	N	0.89	disease_causing	0.96	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7881	7881	C	G	MI.5820	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	296	99	S	W	tCa/tGa	1.91	1	0	possibly_damaging	0.85	neutral	0.25	neutral	1.95	neutral	-2.73	deleterious	-3.68	medium_impact	2.38	0.58	damaging	0.45	neutral	4.26	23.90	deleterious	0.1	0.4	0.82	disease	0.84	disease	0.67	disease	0.74	disease	5	0.89	neutral	0.2	neutral	0	NA	0.77	deleterious	-1.42	low_impact	-0.06	medium_impact	1.13	medium_impact	0.46	0.8	32.16	66.63	0.39	N	0.78	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7883	7883	A	C	MI.5821	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	298	100	I	L	Att/Ctt	-12.85	0	0	benign	0.07	neutral	0.79	neutral	1.91	neutral	-0.72	neutral	-0.53	low_impact	0.86	0.78	neutral	0.91	neutral	0.63	8.39	deleterious	0.39	0.5	0.27	neutral	0.56	disease	0.4	neutral	0.18	neutral	6	0.11	neutral	0.86	deleterious	-6	neutral	0.17	neutral	0.33	medium_impact	0.52	medium_impact	-0.3	medium_impact	0.68	0.85	28.63	65.81	0.26	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7883	7883	A	T	MI.5822	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	298	100	I	F	Att/Ttt	-12.85	0	0	possibly_damaging	0.55	neutral	0.32	neutral	1.81	neutral	-2.29	deleterious	-2.73	medium_impact	2.33	0.58	damaging	0.45	neutral	3.70	23.30	deleterious	0.33	0.5	0.66	disease	0.77	disease	0.6	disease	0.65	disease	3	0.67	neutral	0.39	neutral	0	NA	0.51	deleterious	-0.8	medium_impact	0.02	medium_impact	1.08	medium_impact	0.63	0.8	28.63	65.81	0.31	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7883	7883	A	G	MI.5823	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	298	100	I	V	Att/Gtt	-12.85	0	0	benign	0.01	neutral	0.66	neutral	1.95	neutral	0.17	neutral	-0.39	neutral_impact	0.6	0.79	neutral	0.93	neutral	-0.53	0.19	neutral	0.61	0.65	0.4	neutral	0.16	neutral	0.39	neutral	0.27	neutral	5	0.32	neutral	0.83	deleterious	-6	neutral	0.12	neutral	1.14	medium_impact	0.36	medium_impact	-0.54	medium_impact	0.39	0.8	28.63	65.81	0.35	N	0.55	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7884	7884	T	C	MI.5824	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	299	100	I	T	aTt/aCt	0.75	0.2	0	benign	0.33	neutral	0.77	neutral	1.92	neutral	1	deleterious	-3.36	neutral_impact	-0.06	0.66	neutral	0.66	neutral	0.65	8.48	deleterious	0.39	0.5	0.36	neutral	0.7	disease	0.45	neutral	0.18	neutral	6	0.22	neutral	0.72	deleterious	-6	neutral	0.27	neutral	-0.43	medium_impact	0.5	medium_impact	-1.16	low_impact	0.43	0.8	28.63	65.81	0.23	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7884	7884	T	G	MI.5825	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	299	100	I	S	aTt/aGt	0.75	0.2	0	possibly_damaging	0.62	neutral	0.7	neutral	1.81	neutral	-2.08	deleterious	-4.2	low_impact	1.84	0.57	damaging	0.47	neutral	3.96	23.60	deleterious	0.27	0.45	0.34	neutral	0.81	disease	0.69	disease	0.67	disease	3	0.55	neutral	0.54	deleterious	-3	neutral	0.40	neutral	-0.92	medium_impact	0.41	medium_impact	0.62	medium_impact	0.41	0.8	28.63	65.81	0.28	N	0.56	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7884	7884	T	A	MI.5826	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	299	100	I	N	aTt/aAt	0.75	0.2	0	possibly_damaging	0.88	neutral	0.34	neutral	1.79	neutral	-2.87	deleterious	-5.19	medium_impact	3.08	0.6	damaging	0.42	neutral	4.43	24.20	deleterious	0.25	0.45	0.58	disease	0.86	disease	0.69	disease	0.7	disease	4	0.89	neutral	0.23	neutral	0	NA	0.71	deleterious	-1.53	low_impact	0.05	medium_impact	1.78	medium_impact	0.39	0.8	28.63	65.81	0.3	N	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7885	7885	T	G	MI.5827	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	300	100	I	M	atT/atG	5.83	0.91	0	possibly_damaging	0.79	neutral	0.46	neutral	1.81	neutral	-1.6	neutral	-0.18	neutral_impact	0.8	0.79	neutral	0.98	neutral	1.41	12.82	neutral	0.4	0.5	0.44	neutral	0.34	neutral	0.37	neutral	0.44	neutral	1	0.78	neutral	0.34	neutral	-3	neutral	0.45	deleterious	-1.26	low_impact	0.17	medium_impact	-0.36	medium_impact	0.70	0.85	28.63	65.81	0.5	P	0.06	polymorphism	1	0.01	rs386829019	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7885	7885	T	A	MI.5828	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	300	100	I	M	atT/atA	5.83	0.91	0	possibly_damaging	0.79	neutral	0.46	neutral	1.81	neutral	-1.6	neutral	-0.18	neutral_impact	0.8	0.79	neutral	0.98	neutral	1.66	14.21	neutral	0.4	0.5	0.44	neutral	0.34	neutral	0.37	neutral	0.44	neutral	1	0.78	neutral	0.34	neutral	-3	neutral	0.45	deleterious	-1.26	low_impact	0.17	medium_impact	-0.36	medium_impact	0.70	0.85	28.63	65.81	0.5	P	0.06	polymorphism	1	0.01	rs386829019	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7886	7886	G	T	MI.5829	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	301	101	G	C	Ggc/Tgc	-3.17	0	0	probably_damaging	1	neutral	0.16	neutral	0.9	deleterious	-7.58	deleterious	-8.95	high_impact	4.65	0.27	damaging	0.12	damaging	4.14	23.80	deleterious	0.1	0.4	0.95	disease	0.86	disease	0.74	disease	0.62	disease	2	1	deleterious	0.08	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.19	medium_impact	3.25	high_impact	0.44	0.8	68.28	19.55	0.7	P	0.99	polymorphism	0.96	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8800	8800	T	G	MI.583	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	274	92	F	V	Ttt/Gtt	-3.34	0	0	probably_damaging	0.99	deleterious	0	neutral	4.1	neutral	-1.75	deleterious	-6.43	high_impact	4.17	0.55	damaging	0.09	damaging	4.02	23.60	deleterious	0.35	0.65	0.57	disease	0.75	disease	0.78	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-2.65	low_impact	-1.4	low_impact	2.48	high_impact	0.51	0.9	50	8.7	0.37	N	0.99	disease_causing	0.98	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7886	7886	G	A	MI.5830	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	301	101	G	S	Ggc/Agc	-3.17	0	0	probably_damaging	1	neutral	0.4	neutral	1	deleterious	-4.08	deleterious	-5.96	medium_impact	3.21	0.28	damaging	0.15	damaging	4.20	23.90	deleterious	0.13	0.4	0.49	neutral	0.78	disease	0.64	disease	0.65	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	0.11	medium_impact	1.9	medium_impact	0.54	0.8	68.28	19.55	0.72	P	0.98	polymorphism	0.99	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7886	7886	G	C	MI.5831	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	301	101	G	R	Ggc/Cgc	-3.17	0	0	probably_damaging	1	neutral	0.33	neutral	0.89	deleterious	-7.62	deleterious	-7.96	high_impact	4.3	0.28	damaging	0.1	damaging	3.92	23.50	deleterious	0.09	0.35	0.96	disease	0.84	disease	0.83	disease	0.67	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0.04	medium_impact	2.93	high_impact	0.51	0.8	68.28	19.55	0.7	P	1.00	polymorphism	0.98	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7887	7887	G	C	MI.5832	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	302	101	G	A	gGc/gCc	7.21	1	0	probably_damaging	1	neutral	0.5	neutral	1.26	neutral	-2.1	deleterious	-5.96	medium_impact	2.73	0.35	damaging	0.28	damaging	3.09	22.50	deleterious	0.15	0.45	0.32	neutral	0.67	disease	0.65	disease	0.54	disease	1	1	deleterious	0.25	neutral	1	deleterious	0.76	deleterious	-3.52	low_impact	0.21	medium_impact	1.45	medium_impact	0.59	0.8	68.28	19.55	0.7	P	0.85	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7887	7887	G	T	MI.5833	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	302	101	G	V	gGc/gTc	7.21	1	0	probably_damaging	1	neutral	0.62	neutral	0.91	deleterious	-6.64	deleterious	-8.95	high_impact	4.3	0.28	damaging	0.13	damaging	3.83	23.40	deleterious	0.1	0.4	0.92	disease	0.85	disease	0.73	disease	0.61	disease	2	1	deleterious	0.31	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.32	medium_impact	2.93	high_impact	0.36	0.8	68.28	19.55	0.76	P	1.00	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7887	7887	G	A	MI.5834	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	302	101	G	D	gGc/gAc	7.21	1	0	probably_damaging	1	neutral	0.22	neutral	0.9	deleterious	-6.82	deleterious	-6.96	high_impact	4.65	0.3	damaging	0.11	damaging	3.88	23.50	deleterious	0.1	0.4	0.96	disease	0.85	disease	0.82	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.1	medium_impact	3.25	high_impact	0.37	0.8	68.28	19.55	0.77	P	0.99	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7889	7889	C	G	MI.5835	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	304	102	H	D	Cac/Gac	-20	0	0	probably_damaging	1	neutral	0.62	neutral	1.84	neutral	-1.79	deleterious	-8.96	high_impact	4.4	0.21	damaging	0.02	damaging	3.87	23.50	deleterious	0.2	0.45	0.63	disease	0.81	disease	0.77	disease	0.7	disease	4	1	deleterious	0.31	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.32	medium_impact	3.02	high_impact	0.44	0.8	68.28	19.75	0.5	P	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7889	7889	C	T	MI.5836	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	304	102	H	Y	Cac/Tac	-20	0	0	probably_damaging	1	neutral	0.4	neutral	1.81	neutral	-0.54	deleterious	-5.97	low_impact	1.8	0.19	damaging	0.01	damaging	3.80	23.40	deleterious	0.43	0.55	0.62	disease	0.84	disease	0.75	disease	0.7	disease	4	1	deleterious	0.2	neutral	-2	neutral	0.84	deleterious	-3.52	low_impact	0.11	medium_impact	0.58	medium_impact	0.52	0.8	68.28	19.75	0.61	P	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7889	7889	C	A	MI.5837	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	304	102	H	N	Cac/Aac	-20	0	0	probably_damaging	1	neutral	0.54	neutral	1.84	neutral	-1.18	deleterious	-6.97	medium_impact	2.27	0.17	damaging	0.01	damaging	3.92	23.50	deleterious	0.38	0.5	0.31	neutral	0.82	disease	0.69	disease	0.54	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	0.24	medium_impact	1.02	medium_impact	0.49	0.8	68.28	19.75	0.55	P	0.96	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7890	7890	A	C	MI.5838	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	305	102	H	P	cAc/cCc	7.21	1	0	probably_damaging	1	neutral	0.33	neutral	1.84	deleterious	-3.12	deleterious	-9.96	high_impact	4.4	0.17	damaging	0.02	damaging	3.73	23.30	deleterious	0.2	0.45	0.74	disease	0.85	disease	0.73	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.04	medium_impact	3.02	high_impact	0.38	0.8	68.28	19.75	0.78	P	0.98	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7890	7890	A	T	MI.5839	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	305	102	H	L	cAc/cTc	7.21	1	0	probably_damaging	1	neutral	0.56	neutral	1.86	neutral	-1.8	deleterious	-10.95	medium_impact	3.5	0.15	damaging	0.02	damaging	4.37	24.10	deleterious	0.24	0.45	0.32	neutral	0.89	disease	0.74	disease	0.68	disease	4	1	deleterious	0.28	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.26	medium_impact	2.18	high_impact	0.46	0.8	68.28	19.75	0.75	P	0.91	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8801	8801	T	G	MI.584	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	275	92	F	C	tTt/tGt	5.68	1	0	probably_damaging	1	deleterious	0	neutral	4.02	deleterious	-3.07	deleterious	-7.37	high_impact	4.17	0.55	damaging	0.07	damaging	4.04	23.70	deleterious	0.33	0.65	0.91	disease	0.8	disease	0.78	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	2.48	high_impact	0.26	0.9	50	8.7	0.54	P	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7890	7890	A	G	MI.5840	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	305	102	H	R	cAc/cGc	7.21	1	0	probably_damaging	1	neutral	0.63	neutral	1.88	neutral	-0.84	deleterious	-7.96	medium_impact	2.68	0.19	damaging	0.02	damaging	3.52	23.10	deleterious	0.44	0.55	0.36	neutral	0.8	disease	0.67	disease	0.54	disease	1	1	deleterious	0.32	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.33	medium_impact	1.41	medium_impact	0.43	0.8	68.28	19.75	0.76	P	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7891	7891	C	A	MI.5841	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	306	102	H	Q	caC/caA	8.59	1	0	probably_damaging	1	neutral	0.68	neutral	1.86	neutral	-0.56	deleterious	-7.96	medium_impact	3.36	0.14	damaging	0.02	damaging	3.94	23.50	deleterious	0.47	0.55	0.57	disease	0.76	disease	0.73	disease	0.69	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.39	medium_impact	2.05	high_impact	0.64	0.8	68.28	19.75	0.8	P	0.94	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7891	7891	C	G	MI.5842	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	306	102	H	Q	caC/caG	8.59	1	0	probably_damaging	1	neutral	0.68	neutral	1.86	neutral	-0.56	deleterious	-7.96	medium_impact	3.36	0.14	damaging	0.02	damaging	3.60	23.20	deleterious	0.47	0.55	0.57	disease	0.76	disease	0.73	disease	0.69	disease	4	1	deleterious	0.34	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.39	medium_impact	2.05	high_impact	0.64	0.8	68.28	19.75	0.8	P	0.94	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7892	7892	C	G	MI.5843	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	307	103	Q	E	Caa/Gaa	-5.47	0	0	probably_damaging	0.94	neutral	0.32	neutral	1.6	deleterious	-3.23	deleterious	-2.99	high_impact	3.98	0.33	damaging	0.24	damaging	3.05	22.40	deleterious	0.29	0.45	0.58	disease	0.73	disease	0.81	disease	0.67	disease	3	0.95	neutral	0.19	neutral	2	deleterious	0.82	deleterious	-1.83	low_impact	0.02	medium_impact	2.63	high_impact	0.69	0.85	68.72	19.57	0.58	P	0.85	polymorphism	0.95	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7892	7892	C	A	MI.5844	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	307	103	Q	K	Caa/Aaa	-5.47	0	0	probably_damaging	0.98	neutral	0.24	neutral	1.6	neutral	-2.87	deleterious	-3.98	high_impact	4.33	0.32	damaging	0.23	damaging	4.07	23.70	deleterious	0.26	0.45	0.46	neutral	0.75	disease	0.8	disease	0.67	disease	3	0.98	deleterious	0.13	neutral	2	deleterious	0.81	deleterious	-2.3	low_impact	-0.07	medium_impact	2.95	high_impact	0.61	0.8	68.72	19.57	0.66	P	0.97	polymorphism	0.9	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7893	7893	A	G	MI.5845	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	308	103	Q	R	cAa/cGa	7.21	1	0	probably_damaging	0.98	neutral	0.28	neutral	1.55	deleterious	-3.7	deleterious	-3.98	high_impact	3.58	0.32	damaging	0.25	damaging	3.50	23.10	deleterious	0.26	0.45	0.55	disease	0.81	disease	0.78	disease	0.69	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-2.3	low_impact	-0.02	medium_impact	2.25	high_impact	0.58	0.8	68.72	19.57	0.79	P	0.95	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7893	7893	A	C	MI.5846	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	308	103	Q	P	cAa/cCa	7.21	1	0	probably_damaging	0.99	neutral	0.24	neutral	1.51	deleterious	-5.37	deleterious	-5.97	high_impact	4.12	0.33	damaging	0.22	damaging	3.39	23.00	deleterious	0.2	0.45	0.69	disease	0.83	disease	0.74	disease	0.7	disease	4	0.99	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-2.58	low_impact	-0.07	medium_impact	2.76	high_impact	0.54	0.8	68.72	19.57	0.74	P	0.95	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7893	7893	A	T	MI.5847	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	308	103	Q	L	cAa/cTa	7.21	1	0	probably_damaging	0.98	neutral	0.56	neutral	1.51	deleterious	-3.88	deleterious	-6.97	high_impact	3.7	0.29	damaging	0.37	neutral	3.82	23.40	deleterious	0.17	0.45	0.5	neutral	0.87	disease	0.73	disease	0.7	disease	4	0.97	neutral	0.29	neutral	2	deleterious	0.84	deleterious	-2.3	low_impact	0.26	medium_impact	2.36	high_impact	0.39	0.8	68.72	19.57	0.89	P	0.97	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7894	7894	A	T	MI.5848	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	309	103	Q	H	caA/caT	5.6	1	0	probably_damaging	1	neutral	0.52	neutral	1.49	deleterious	-5.12	deleterious	-4.98	high_impact	4.33	0.3	damaging	0.22	damaging	3.64	23.20	deleterious	0.31	0.45	0.81	disease	0.74	disease	0.81	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.22	medium_impact	2.95	high_impact	0.77	0.85	68.72	19.57	0.84	P	0.86	disease_causing	1	0.28	rs386829020	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7894	7894	A	C	MI.5849	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	309	103	Q	H	caA/caC	5.6	1	0	probably_damaging	1	neutral	0.52	neutral	1.49	deleterious	-5.12	deleterious	-4.98	high_impact	4.33	0.3	damaging	0.22	damaging	3.59	23.20	deleterious	0.31	0.45	0.81	disease	0.74	disease	0.81	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.22	medium_impact	2.95	high_impact	0.77	0.85	68.72	19.57	0.83	P	0.86	disease_causing	1	0.28	rs386829020	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8801	8801	T	C	MI.585	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	275	92	F	S	tTt/tCt	5.68	1	0	probably_damaging	0.99	deleterious	0	neutral	4.01	deleterious	-3.36	deleterious	-7.31	medium_impact	3.42	0.55	damaging	0.11	damaging	4.24	23.90	deleterious	0.33	0.65	0.74	disease	0.78	disease	0.75	disease	0.71	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-2.65	low_impact	-1.4	low_impact	1.83	medium_impact	0.31	0.9	50	8.7	0.47	N	0.99	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7895	7895	T	G	MI.5850	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	310	104	W	G	Tgg/Ggg	-0.17	0.58	0	probably_damaging	1	neutral	0.28	neutral	1.02	deleterious	-7.74	deleterious	-12.94	high_impact	4.68	0.16	damaging	0.01	damaging	3.93	23.50	deleterious	0.15	0.4	0.95	disease	0.8	disease	0.81	disease	0.7	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.02	medium_impact	3.28	high_impact	0.19	0.8	68.72	19.46	0.66	P	0.98	disease_causing	0.96	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7895	7895	T	C	MI.5851	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	310	104	W	R	Tgg/Cgg	-0.17	0.58	0	probably_damaging	1	neutral	0.15	neutral	1.03	deleterious	-7.42	deleterious	-13.94	high_impact	4.68	0.19	damaging	0.01	damaging	3.65	23.20	deleterious	0.18	0.45	0.94	disease	0.86	disease	0.84	disease	0.64	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.21	medium_impact	3.28	high_impact	0.19	0.8	68.72	19.46	0.64	P	0.96	disease_causing	0.9	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7896	7896	G	T	MI.5852	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	311	104	W	L	tGg/tTg	5.6	1	0	probably_damaging	1	neutral	0.39	neutral	1.15	deleterious	-5.63	deleterious	-12.94	high_impact	4.34	0.22	damaging	0.02	damaging	4.28	24.00	deleterious	0.12	0.4	0.88	disease	0.84	disease	0.79	disease	0.63	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.1	medium_impact	2.96	high_impact	0.17	0.8	68.72	19.46	0.72	P	0.98	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7896	7896	G	C	MI.5853	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	311	104	W	S	tGg/tCg	5.6	1	0	probably_damaging	1	neutral	0.17	neutral	1.03	deleterious	-7.15	deleterious	-13.94	high_impact	4.34	0.15	damaging	0.01	damaging	4.05	23.70	deleterious	0.15	0.4	0.63	disease	0.85	disease	0.79	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.18	medium_impact	2.96	high_impact	0.20	0.8	68.72	19.46	0.7	P	0.97	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7897	7897	G	C	MI.5854	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	312	104	W	C	tgG/tgC	7.44	1	0	probably_damaging	1	neutral	0.08	neutral	1.02	deleterious	-8.62	deleterious	-12.94	high_impact	4.68	0.16	damaging	0.01	damaging	4.03	23.70	deleterious	0.17	0.45	0.98	disease	0.85	disease	0.83	disease	0.67	disease	3	1	deleterious	0.04	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.38	medium_impact	3.28	high_impact	0.26	0.8	68.72	19.46	0.7	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7897	7897	G	T	MI.5855	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	312	104	W	C	tgG/tgT	7.44	1	0	probably_damaging	1	neutral	0.08	neutral	1.02	deleterious	-8.62	deleterious	-12.94	high_impact	4.68	0.16	damaging	0.01	damaging	4.19	23.80	deleterious	0.17	0.45	0.98	disease	0.85	disease	0.83	disease	0.67	disease	3	1	deleterious	0.04	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.38	medium_impact	3.28	high_impact	0.26	0.8	68.72	19.46	0.7	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7898	7898	T	C	MI.5856	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	313	105	Y	H	Tac/Cac	3.29	1	0	probably_damaging	1	neutral	0.25	neutral	1.78	neutral	-2.59	deleterious	-4.97	high_impact	4.32	0.12	damaging	0.03	damaging	3.64	23.20	deleterious	0.4	0.5	0.7	disease	0.72	disease	0.78	disease	0.7	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.06	medium_impact	2.95	high_impact	0.36	0.8	68.28	19.32	0.87	P	0.94	disease_causing	0.88	0.09	.	.	.	.	.	.	COSM488771	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7898	7898	T	G	MI.5857	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	313	105	Y	D	Tac/Gac	3.29	1	0	probably_damaging	1	neutral	0.1	neutral	1.79	neutral	-1.63	deleterious	-9.95	high_impact	4.32	0.19	damaging	0.02	damaging	4.01	23.60	deleterious	0.22	0.45	0.58	disease	0.83	disease	0.79	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.32	medium_impact	2.95	high_impact	0.28	0.8	68.28	19.32	0.79	P	0.99	disease_causing	0.98	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7898	7898	T	A	MI.5858	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	313	105	Y	N	Tac/Aac	3.29	1	0	probably_damaging	1	neutral	0.08	neutral	1.81	neutral	-0.92	deleterious	-8.95	medium_impact	3.22	0.16	damaging	0.02	damaging	4.09	23.70	deleterious	0.35	0.5	0.57	disease	0.86	disease	0.73	disease	0.7	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	-0.38	medium_impact	1.91	medium_impact	0.23	0.8	68.28	19.32	0.83	P	0.99	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7899	7899	A	T	MI.5859	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	314	105	Y	F	tAc/tTc	7.44	1	0	probably_damaging	1	neutral	0.22	neutral	1.82	neutral	-2.55	deleterious	-3.97	low_impact	1.46	0.21	damaging	0.08	damaging	3.46	23.00	deleterious	0.39	0.5	0.67	disease	0.75	disease	0.61	disease	0.37	neutral	3	1	deleterious	0.11	neutral	-2	neutral	0.83	deleterious	-3.52	low_impact	-0.1	medium_impact	0.26	medium_impact	0.50	0.8	68.28	19.32	0.88	P	0.87	disease_causing	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8801	8801	T	A	MI.586	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	275	92	F	Y	tTt/tAt	5.68	1	0	probably_damaging	0.98	neutral	0.15	neutral	4.02	deleterious	-3.03	deleterious	-2.73	medium_impact	2.24	0.62	neutral	0.13	damaging	4.23	23.90	deleterious	0.42	0.65	0.78	disease	0.61	disease	0.57	disease	0.37	neutral	3	0.99	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-2.36	low_impact	-0.13	medium_impact	0.82	medium_impact	0.68	0.9	50	8.7	0.57	P	0.89	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7899	7899	A	G	MI.5860	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	314	105	Y	C	tAc/tGc	7.44	1	0	probably_damaging	1	neutral	0.05	neutral	1.77	deleterious	-4.54	deleterious	-8.94	high_impact	4.32	0.13	damaging	0.02	damaging	3.56	23.10	deleterious	0.36	0.5	0.86	disease	0.84	disease	0.74	disease	0.64	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.5	medium_impact	2.95	high_impact	0.16	0.8	68.28	19.32	0.84	P	0.96	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7899	7899	A	C	MI.5861	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	314	105	Y	S	tAc/tCc	7.44	1	0	probably_damaging	1	neutral	0.1	neutral	1.83	neutral	-0.7	deleterious	-8.95	high_impact	3.77	0.13	damaging	0.03	damaging	3.77	23.40	deleterious	0.29	0.45	0.43	neutral	0.8	disease	0.72	disease	0.67	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	-0.32	medium_impact	2.43	high_impact	0.24	0.8	68.28	19.32	0.85	P	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7901	7901	T	C	MI.5862	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	316	106	W	R	Tga/Cga	-1.32	0	0	probably_damaging	1	neutral	0.05	neutral	1.47	deleterious	-6.31	deleterious	-13.94	high_impact	4.12	0.19	damaging	0.01	damaging	3.64	23.20	deleterious	0.19	0.45	0.85	disease	0.88	disease	0.84	disease	0.66	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.5	medium_impact	2.76	high_impact	0.19	0.8	68.72	19.55	0.64	P	0.96	disease_causing	0.74	0.28	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7901	7901	T	G	MI.5863	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	316	106	W	G	Tga/Gga	-1.32	0	0	probably_damaging	1	neutral	0.05	neutral	1.46	deleterious	-7.79	deleterious	-12.94	high_impact	4.33	0.15	damaging	0.01	damaging	3.93	23.50	deleterious	0.16	0.45	0.9	disease	0.81	disease	0.8	disease	0.65	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.5	medium_impact	2.95	high_impact	0.25	0.8	68.72	19.55	0.63	P	0.98	disease_causing	0.88	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7902	7902	G	T	MI.5864	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	317	106	W	L	tGa/tTa	5.83	1	0	probably_damaging	1	neutral	0.16	neutral	1.52	deleterious	-5.67	deleterious	-12.94	high_impact	4.33	0.2	damaging	0.02	damaging	4.21	23.90	deleterious	0.13	0.4	0.89	disease	0.86	disease	0.79	disease	0.62	disease	2	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.19	medium_impact	2.95	high_impact	0.20	0.8	68.72	19.55	0.74	P	0.98	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7902	7902	G	C	MI.5865	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	317	106	W	S	tGa/tCa	5.83	1	0	probably_damaging	1	neutral	0.23	neutral	1.48	deleterious	-6.83	deleterious	-13.94	high_impact	4.12	0.14	damaging	0.01	damaging	4.03	23.60	deleterious	0.16	0.45	0.72	disease	0.88	disease	0.79	disease	0.71	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.09	medium_impact	2.76	high_impact	0.21	0.8	68.72	19.55	0.71	P	0.97	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7903	7903	A	C	MI.5866	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	318	106	W	C	tgA/tgC	7.21	1	0	probably_damaging	1	deleterious	0.03	neutral	1.43	deleterious	-8.59	deleterious	-12.94	high_impact	4.67	0.16	damaging	0.01	damaging	4.05	23.70	deleterious	0.18	0.45	0.96	disease	0.88	disease	0.81	disease	0.63	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.91	deleterious	-3.52	low_impact	-0.63	medium_impact	3.27	high_impact	0.24	0.8	68.72	19.55	0.72	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7903	7903	A	T	MI.5867	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	318	106	W	C	tgA/tgT	7.21	1	0	probably_damaging	1	deleterious	0.03	neutral	1.43	deleterious	-8.59	deleterious	-12.94	high_impact	4.67	0.16	damaging	0.01	damaging	4.17	23.80	deleterious	0.18	0.45	0.96	disease	0.88	disease	0.81	disease	0.63	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.91	deleterious	-3.52	low_impact	-0.63	medium_impact	3.27	high_impact	0.24	0.8	68.72	19.55	0.73	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7904	7904	A	C	MI.5868	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	319	107	T	P	Acc/Ccc	5.83	1	0	possibly_damaging	0.46	neutral	0.2	neutral	1.9	neutral	-2.11	deleterious	-2.56	medium_impact	2.48	0.58	damaging	0.37	neutral	3.29	22.80	deleterious	0.11	0.4	0.81	disease	0.8	disease	0.58	disease	0.72	disease	4	0.77	neutral	0.37	neutral	0	NA	0.70	deleterious	-0.66	medium_impact	-0.13	medium_impact	1.22	medium_impact	0.63	0.8	28.19	64.45	0.53	P	0.61	disease_causing	0.97	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7904	7904	A	T	MI.5869	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	319	107	T	S	Acc/Tcc	5.83	1	0	benign	0.14	neutral	0.51	neutral	2.27	neutral	1.73	neutral	1.76	neutral_impact	-1.77	0.72	neutral	0.97	neutral	-1.11	0.01	neutral	0.27	0.45	0.37	neutral	0.02	neutral	0.16	neutral	0.22	neutral	6	0.4	neutral	0.69	deleterious	-6	neutral	0.22	neutral	0.01	medium_impact	0.21	medium_impact	-2.77	low_impact	0.68	0.85	28.19	64.45	0.62	P	0.01	disease_causing	0.66	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8802	8802	T	A	MI.587	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	276	92	F	L	ttT/ttA	4.52	1	0	probably_damaging	0.98	deleterious	0.02	neutral	4.19	neutral	-1.01	deleterious	-5.51	high_impact	3.54	0.56	damaging	0.06	damaging	4.39	24.10	deleterious	0.44	0.65	0.68	disease	0.69	disease	0.75	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.36	low_impact	-0.66	medium_impact	1.94	medium_impact	0.64	0.9	50	8.7	0.54	P	0.89	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7904	7904	A	G	MI.5870	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	319	107	T	A	Acc/Gcc	5.83	1	0	benign	0.01	neutral	0.47	neutral	1.99	neutral	-0.13	neutral	-0.64	low_impact	1.45	0.83	neutral	0.76	neutral	1.63	14.00	neutral	0.28	0.45	0.59	disease	0.47	neutral	0.59	disease	0.63	disease	3	0.52	neutral	0.73	deleterious	-6	neutral	0.29	neutral	1.14	medium_impact	0.18	medium_impact	0.25	medium_impact	0.57	0.8	28.19	64.45	0.53	N	0.14	disease_causing	0.85	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7905	7905	C	T	MI.5871	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	320	107	T	I	aCc/aTc	3.06	1	0	benign	0.31	neutral	0.36	neutral	1.91	neutral	-1.77	deleterious	-3.38	low_impact	1.94	0.66	neutral	0.58	neutral	2.25	17.86	deleterious	0.33	0.5	0.54	disease	0.6	disease	0.56	disease	0.68	disease	4	0.57	neutral	0.53	deleterious	-6	neutral	0.47	deleterious	-0.4	medium_impact	0.07	medium_impact	0.71	medium_impact	0.75	0.85	28.19	64.45	0.45	N	0.78	polymorphism	0.77	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7905	7905	C	G	MI.5872	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	320	107	T	S	aCc/aGc	3.06	1	0	benign	0.14	neutral	0.51	neutral	2.27	neutral	1.73	neutral	1.76	neutral_impact	-1.77	0.72	neutral	0.97	neutral	-1.01	0.02	neutral	0.27	0.45	0.37	neutral	0.02	neutral	0.16	neutral	0.22	neutral	6	0.4	neutral	0.69	deleterious	-6	neutral	0.22	neutral	0.01	medium_impact	0.21	medium_impact	-2.77	low_impact	0.68	0.85	28.19	64.45	0.53	P	0.01	polymorphism	0.97	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7905	7905	C	A	MI.5873	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	320	107	T	N	aCc/aAc	3.06	1	0	possibly_damaging	0.46	neutral	0.28	neutral	1.93	neutral	-1.06	neutral	-0.8	neutral_impact	0.13	0.63	neutral	0.58	neutral	2.24	17.75	deleterious	0.36	0.5	0.66	disease	0.76	disease	0.42	neutral	0.28	neutral	4	0.69	neutral	0.41	neutral	-3	neutral	0.56	deleterious	-0.66	medium_impact	-0.02	medium_impact	-0.98	medium_impact	0.62	0.8	28.19	64.45	0.42	N	0.37	polymorphism	0.78	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7907	7907	T	C	MI.5874	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	322	108	Y	H	Tac/Cac	-2.01	0	0	probably_damaging	1	neutral	0.13	neutral	0.98	deleterious	-5.46	deleterious	-4.98	high_impact	3.92	0.11	damaging	0.02	damaging	3.63	23.20	deleterious	0.27	0.45	0.86	disease	0.75	disease	0.76	disease	0.65	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.25	medium_impact	2.57	high_impact	0.37	0.8	67.84	19.73	0.81	P	0.94	disease_causing	0.57	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7907	7907	T	A	MI.5875	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	322	108	Y	N	Tac/Aac	-2.01	0	0	probably_damaging	1	neutral	0.13	neutral	0.98	deleterious	-5.84	deleterious	-8.96	high_impact	4.27	0.15	damaging	0.02	damaging	4.11	23.80	deleterious	0.27	0.45	0.87	disease	0.86	disease	0.75	disease	0.62	disease	2	1	deleterious	0.07	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.25	medium_impact	2.9	high_impact	0.21	0.8	67.84	19.73	0.71	P	0.99	disease_causing	0.94	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7907	7907	T	G	MI.5876	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	322	108	Y	D	Tac/Gac	-2.01	0	0	probably_damaging	1	neutral	0.1	neutral	0.97	deleterious	-6.09	deleterious	-9.96	high_impact	4.62	0.18	damaging	0.02	damaging	4.05	23.70	deleterious	0.18	0.45	0.92	disease	0.84	disease	0.8	disease	0.67	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.32	medium_impact	3.23	high_impact	0.29	0.8	67.84	19.73	0.69	P	0.99	disease_causing	0.92	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7908	7908	A	G	MI.5877	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	323	108	Y	C	tAc/tGc	7.44	1	0	probably_damaging	1	deleterious	0.04	neutral	0.96	deleterious	-7.26	deleterious	-8.96	high_impact	4.27	0.13	damaging	0.03	damaging	3.63	23.20	deleterious	0.32	0.5	0.89	disease	0.85	disease	0.76	disease	0.62	disease	2	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-3.52	low_impact	-0.56	medium_impact	2.9	high_impact	0.23	0.8	67.84	19.73	0.82	P	0.96	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7908	7908	A	C	MI.5878	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	323	108	Y	S	tAc/tCc	7.44	1	0	probably_damaging	1	neutral	0.16	neutral	0.99	deleterious	-5.38	deleterious	-8.96	high_impact	4.27	0.11	damaging	0.03	damaging	3.81	23.40	deleterious	0.23	0.45	0.77	disease	0.8	disease	0.73	disease	0.69	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.19	medium_impact	2.9	high_impact	0.29	0.8	67.84	19.73	0.84	P	0.99	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7908	7908	A	T	MI.5879	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	323	108	Y	F	tAc/tTc	7.44	1	0	probably_damaging	0.99	neutral	0.17	neutral	1.1	deleterious	-3.31	deleterious	-3.98	medium_impact	2.8	0.14	damaging	0.02	damaging	3.55	23.10	deleterious	0.27	0.45	0.3	neutral	0.8	disease	0.67	disease	0.65	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.78	deleterious	-2.58	low_impact	-0.18	medium_impact	1.52	medium_impact	0.51	0.8	67.84	19.73	0.89	P	0.87	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8802	8802	T	G	MI.588	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	276	92	F	L	ttT/ttG	4.52	1	0	probably_damaging	0.98	deleterious	0.02	neutral	4.19	neutral	-1.01	deleterious	-5.51	high_impact	3.54	0.56	damaging	0.06	damaging	4.28	24.00	deleterious	0.44	0.65	0.68	disease	0.69	disease	0.75	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-2.36	low_impact	-0.66	medium_impact	1.94	medium_impact	0.64	0.9	50	8.7	0.53	P	0.89	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7910	7910	G	C	MI.5880	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	325	109	E	Q	Gag/Cag	-2.71	0	0	probably_damaging	1	neutral	0.2	neutral	1.54	neutral	-2.62	deleterious	-2.98	medium_impact	2.9	0.16	damaging	0.06	damaging	3.40	23.00	deleterious	0.33	0.5	0.52	disease	0.67	disease	0.66	disease	0.64	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.13	medium_impact	1.61	medium_impact	0.71	0.85	67.4	19.68	0.8	P	0.76	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7910	7910	G	A	MI.5881	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	325	109	E	K	Gag/Aag	-2.71	0	0	probably_damaging	1	neutral	0.24	neutral	1.54	neutral	-2.62	deleterious	-3.98	medium_impact	3.17	0.13	damaging	0.02	damaging	4.55	24.40	deleterious	0.29	0.45	0.37	neutral	0.82	disease	0.78	disease	0.68	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	-0.07	medium_impact	1.87	medium_impact	0.77	0.85	67.4	19.68	0.8	P	0.99	polymorphism	0.98	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7911	7911	A	G	MI.5882	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	326	109	E	G	gAg/gGg	6.06	1	0	probably_damaging	1	neutral	0.22	neutral	1.48	deleterious	-3.74	deleterious	-6.97	high_impact	3.86	0.11	damaging	0.05	damaging	4.41	24.10	deleterious	0.29	0.45	0.7	disease	0.73	disease	0.77	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	-0.1	medium_impact	2.51	high_impact	0.35	0.8	67.4	19.68	0.89	P	0.64	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7911	7911	A	C	MI.5883	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	326	109	E	A	gAg/gCg	6.06	1	0	probably_damaging	1	neutral	0.34	neutral	1.51	deleterious	-3.15	deleterious	-5.97	medium_impact	3.4	0.2	damaging	0.1	damaging	3.82	23.40	deleterious	0.27	0.45	0.54	disease	0.77	disease	0.76	disease	0.69	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	0.05	medium_impact	2.08	high_impact	0.48	0.8	67.4	19.68	0.9	P	0.66	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7911	7911	A	T	MI.5884	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	326	109	E	V	gAg/gTg	6.06	1	0	probably_damaging	1	neutral	0.38	neutral	1.46	deleterious	-4.34	deleterious	-6.97	medium_impact	3.46	0.13	damaging	0.03	damaging	4.39	24.10	deleterious	0.23	0.45	0.72	disease	0.87	disease	0.78	disease	0.7	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.87	deleterious	-3.52	low_impact	0.09	medium_impact	2.14	high_impact	0.55	0.8	67.4	19.68	0.88	P	0.82	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7912	7912	G	C	MI.5885	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	327	109	E	D	gaG/gaC	6.98	1	0.01	probably_damaging	0.99	neutral	0.14	neutral	1.56	neutral	-2.3	deleterious	-2.99	medium_impact	2.66	0.2	damaging	0.04	damaging	3.75	23.30	deleterious	0.29	0.45	0.42	neutral	0.71	disease	0.73	disease	0.67	disease	3	1	deleterious	0.08	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	-0.23	medium_impact	1.39	medium_impact	0.75	0.85	67.4	19.68	0.89	P	0.81	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7912	7912	G	T	MI.5886	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	327	109	E	D	gaG/gaT	6.98	1	0.01	probably_damaging	0.99	neutral	0.14	neutral	1.56	neutral	-2.3	deleterious	-2.99	medium_impact	2.66	0.2	damaging	0.04	damaging	3.88	23.50	deleterious	0.29	0.45	0.42	neutral	0.71	disease	0.73	disease	0.67	disease	3	1	deleterious	0.08	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	-0.23	medium_impact	1.39	medium_impact	0.75	0.85	67.4	19.68	0.89	P	0.81	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7913	7913	T	A	MI.5887	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	328	110	Y	N	Tac/Aac	-2.01	0	0	probably_damaging	1	neutral	0.13	neutral	1.47	deleterious	-6.9	deleterious	-8.8	high_impact	3.7	0.35	damaging	0.03	damaging	4.27	24.00	deleterious	0.28	0.45	0.84	disease	0.89	disease	0.73	disease	0.65	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.25	medium_impact	2.36	high_impact	0.19	0.8	69.16	19.05	0.48	N	0.99	disease_causing	0.56	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7913	7913	T	G	MI.5888	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	328	110	Y	D	Tac/Gac	-2.01	0	0	probably_damaging	1	neutral	0.08	neutral	1.46	deleterious	-7.44	deleterious	-9.75	high_impact	4.05	0.34	damaging	0.03	damaging	4.04	23.70	deleterious	0.17	0.45	0.92	disease	0.85	disease	0.76	disease	0.61	disease	2	1	deleterious	0.04	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.38	medium_impact	2.69	high_impact	0.25	0.8	69.16	19.05	0.48	N	0.99	polymorphism	0.52	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7913	7913	T	C	MI.5889	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	328	110	Y	H	Tac/Cac	-2.01	0	0	probably_damaging	1	neutral	0.2	neutral	1.47	deleterious	-5.85	deleterious	-4.92	high_impact	3.5	0.33	damaging	0.02	damaging	3.66	23.20	deleterious	0.33	0.5	0.79	disease	0.78	disease	0.7	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.13	medium_impact	2.18	high_impact	0.33	0.8	69.16	19.05	0.45	N	0.94	polymorphism	0.9	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8803	8803	A	T	MI.589	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	277	93	T	S	Aca/Tca	-5.89	0	0.01	probably_damaging	0.99	neutral	0.17	neutral	4.15	neutral	-2.53	deleterious	-3.46	medium_impact	2.08	0.6	neutral	0.54	neutral	3.17	22.70	deleterious	0.46	0.65	0.52	disease	0.35	neutral	0.59	disease	0.45	neutral	1	0.99	deleterious	0.09	neutral	1	deleterious	0.71	deleterious	-2.65	low_impact	-0.1	medium_impact	0.69	medium_impact	0.57	0.9	46.02	8.31	0.37	N	0.88	polymorphism	0.95	0.11	rs878853020	Uncertain_significance	not_provided	237056	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7914	7914	A	G	MI.5890	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	329	110	Y	C	tAc/tGc	5.83	1	0	probably_damaging	1	neutral	0.06	neutral	1.45	deleterious	-7.7	deleterious	-8.75	high_impact	3.85	0.27	damaging	0.03	damaging	3.62	23.20	deleterious	0.28	0.45	0.95	disease	0.89	disease	0.76	disease	0.63	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.46	medium_impact	2.5	high_impact	0.22	0.8	69.16	19.05	0.74	P	0.96	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7914	7914	A	C	MI.5891	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	329	110	Y	S	tAc/tCc	5.83	1	0	probably_damaging	1	neutral	0.28	neutral	1.48	deleterious	-6.02	deleterious	-8.75	high_impact	3.85	0.33	damaging	0.05	damaging	3.82	23.40	deleterious	0.24	0.45	0.85	disease	0.82	disease	0.72	disease	0.63	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.02	medium_impact	2.5	high_impact	0.26	0.8	69.16	19.05	0.63	P	0.99	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7914	7914	A	T	MI.5892	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	329	110	Y	F	tAc/tTc	5.83	1	0	probably_damaging	1	neutral	0.28	neutral	1.61	deleterious	-4.55	deleterious	-3.63	medium_impact	2.42	0.48	damaging	0.39	neutral	2.39	18.77	deleterious	0.26	0.45	0.77	disease	0.78	disease	0.65	disease	0.39	neutral	2	1	deleterious	0.14	neutral	1	deleterious	0.87	deleterious	-3.52	low_impact	-0.02	medium_impact	1.16	medium_impact	0.44	0.8	69.16	19.05	0.63	P	0.87	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7916	7916	A	G	MI.5893	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	331	111	T	A	Acc/Gcc	-2.94	0	0	probably_damaging	0.99	neutral	0.55	neutral	2.01	neutral	0.46	deleterious	-3.66	low_impact	1.21	0.64	neutral	0.52	neutral	3.38	22.90	deleterious	0.44	0.55	0.34	neutral	0.55	disease	0.49	neutral	0.38	neutral	2	0.99	deleterious	0.28	neutral	-2	neutral	0.74	deleterious	-2.58	low_impact	0.25	medium_impact	0.03	medium_impact	0.51	0.8	68.28	16.39	0.27	N	0.65	polymorphism	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7916	7916	A	T	MI.5894	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	331	111	T	S	Acc/Tcc	-2.94	0	0	probably_damaging	0.99	neutral	0.66	neutral	2.09	neutral	0.45	neutral	-2.4	neutral_impact	-1.07	0.61	neutral	0.77	neutral	1.51	13.38	neutral	0.41	0.5	0.21	neutral	0.03	neutral	0.21	neutral	0.23	neutral	5	0.99	deleterious	0.34	neutral	-2	neutral	0.66	deleterious	-2.58	low_impact	0.36	medium_impact	-2.11	low_impact	0.46	0.8	68.28	16.39	0.33	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7916	7916	A	C	MI.5895	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	331	111	T	P	Acc/Ccc	-2.94	0	0	probably_damaging	1	neutral	0.27	neutral	2.13	neutral	2.04	deleterious	-5	neutral_impact	0.3	0.43	damaging	0.3	neutral	3.48	23.10	deleterious	0.39	0.5	0.17	neutral	0.83	disease	0.53	disease	0.55	disease	1	1	deleterious	0.14	neutral	-2	neutral	0.77	deleterious	-3.52	low_impact	-0.03	medium_impact	-0.82	medium_impact	0.57	0.8	68.28	16.39	0.39	N	0.90	polymorphism	0.95	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7917	7917	C	G	MI.5896	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	332	111	T	S	aCc/aGc	6.75	1	0	probably_damaging	0.99	neutral	0.66	neutral	2.09	neutral	0.45	neutral	-2.4	neutral_impact	-1.07	0.61	neutral	0.77	neutral	1.83	15.15	deleterious	0.41	0.5	0.21	neutral	0.03	neutral	0.21	neutral	0.23	neutral	5	0.99	deleterious	0.34	neutral	-2	neutral	0.66	deleterious	-2.58	low_impact	0.36	medium_impact	-2.11	low_impact	0.46	0.8	68.28	16.39	0.51	P	0.80	disease_causing	0.83	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7917	7917	C	A	MI.5897	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	332	111	T	N	aCc/aAc	6.75	1	0	probably_damaging	1	neutral	0.34	neutral	1.96	neutral	-0.68	deleterious	-3.86	neutral_impact	0.59	0.5	damaging	0.34	neutral	3.72	23.30	deleterious	0.55	0.6	0.36	neutral	0.83	disease	0.5	neutral	0.69	disease	4	1	deleterious	0.17	neutral	-2	neutral	0.78	deleterious	-3.52	low_impact	0.05	medium_impact	-0.55	medium_impact	0.62	0.8	68.28	16.39	0.47	N	0.87	disease_causing	0.98	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7917	7917	C	T	MI.5898	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	332	111	T	I	aCc/aTc	6.75	1	0	probably_damaging	1	neutral	0.42	neutral	2.05	neutral	-0.77	deleterious	-5.19	low_impact	1.38	0.51	damaging	0.44	neutral	4.04	23.70	deleterious	0.5	0.6	0.59	disease	0.73	disease	0.57	disease	0.68	disease	4	1	deleterious	0.21	neutral	-2	neutral	0.83	deleterious	-3.52	low_impact	0.13	medium_impact	0.19	medium_impact	0.54	0.8	68.28	16.39	0.48	N	0.77	disease_causing	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7919	7919	G	A	MI.5899	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	334	112	D	N	Gac/Aac	-5.93	0	0	probably_damaging	1	neutral	0.35	neutral	1.59	neutral	-2.16	deleterious	-4.55	medium_impact	2.04	0.5	damaging	0.51	neutral	4.16	23.80	deleterious	0.69	0.75	0.46	neutral	0.8	disease	0.59	disease	0.34	neutral	3	1	deleterious	0.18	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	0.06	medium_impact	0.81	medium_impact	0.68	0.85	67.84	19.4	0.38	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8552	8552	T	C	MI.59	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	26	9	F	S	tTc/tCc	7.53	1	0	probably_damaging	0.97	deleterious	0	neutral	3.85	neutral	-2.62	deleterious	-7	medium_impact	3.24	0.63	neutral	0.73	neutral	4.04	23.70	deleterious	0.43	0.65	0.66	disease	0.84	disease	0.83	disease	0.84	disease	7	1	deleterious	0.02	neutral	5	deleterious	0.82	deleterious	-2.19	low_impact	-1.4	low_impact	1.68	medium_impact	0.39	0.9	49.56	8.77	0.6	P	0.99	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8803	8803	A	C	MI.590	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	277	93	T	P	Aca/Cca	-5.89	0	0.01	probably_damaging	1	neutral	0.05	neutral	4.14	neutral	-2.87	deleterious	-5.37	medium_impact	3.22	0.53	damaging	0.41	neutral	3.47	23.00	deleterious	0.18	0.65	0.71	disease	0.67	disease	0.59	disease	0.63	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.43	medium_impact	1.66	medium_impact	0.50	0.9	46.02	8.31	0.35	N	0.99	polymorphism	0.56	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7919	7919	G	T	MI.5900	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	334	112	D	Y	Gac/Tac	-5.93	0	0	probably_damaging	1	neutral	0.71	neutral	1.47	deleterious	-5.38	deleterious	-8.7	high_impact	3.88	0.43	damaging	0.22	damaging	3.92	23.50	deleterious	0.28	0.45	0.92	disease	0.91	disease	0.68	disease	0.59	disease	2	1	deleterious	0.36	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.42	medium_impact	2.53	high_impact	0.35	0.8	67.84	19.4	0.41	N	0.99	polymorphism	0.98	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7919	7919	G	C	MI.5901	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	334	112	D	H	Gac/Cac	-5.93	0	0	probably_damaging	1	neutral	0.29	neutral	1.49	deleterious	-4.35	deleterious	-6.67	high_impact	3.88	0.43	damaging	0.23	damaging	3.67	23.30	deleterious	0.53	0.6	0.86	disease	0.77	disease	0.73	disease	0.64	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.01	medium_impact	2.53	high_impact	0.65	0.8	67.84	19.4	0.43	N	0.98	polymorphism	0.99	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7920	7920	A	G	MI.5902	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	335	112	D	G	gAc/gGc	6.06	1	0	probably_damaging	1	neutral	0.37	neutral	1.51	deleterious	-3.52	deleterious	-6.7	medium_impact	2.68	0.46	damaging	0.34	neutral	4.14	23.80	deleterious	0.51	0.6	0.44	neutral	0.79	disease	0.68	disease	0.65	disease	3	1	deleterious	0.19	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	0.08	medium_impact	1.41	medium_impact	0.46	0.8	67.84	19.4	0.54	P	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7920	7920	A	C	MI.5903	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	335	112	D	A	gAc/gCc	6.06	1	0	probably_damaging	1	neutral	0.51	neutral	1.53	deleterious	-3.09	deleterious	-7.75	medium_impact	3.23	0.46	damaging	0.36	neutral	3.78	23.40	deleterious	0.37	0.5	0.75	disease	0.81	disease	0.69	disease	0.66	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	0.21	medium_impact	1.92	medium_impact	0.66	0.8	67.84	19.4	0.56	P	0.96	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7920	7920	A	T	MI.5904	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	335	112	D	V	gAc/gTc	6.06	1	0	probably_damaging	1	neutral	0.36	neutral	1.48	deleterious	-4.52	deleterious	-8.74	high_impact	3.73	0.4	damaging	0.24	damaging	3.94	23.50	deleterious	0.31	0.45	0.88	disease	0.87	disease	0.7	disease	0.62	disease	2	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.07	medium_impact	2.39	high_impact	0.40	0.8	67.84	19.4	0.71	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7921	7921	C	G	MI.5905	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	336	112	D	E	gaC/gaG	8.59	1	0	probably_damaging	1	neutral	0.72	neutral	1.65	neutral	-1.68	deleterious	-3.85	medium_impact	2.46	0.43	damaging	0.22	damaging	3.95	23.60	deleterious	0.58	0.65	0.59	disease	0.74	disease	0.57	disease	0.64	disease	3	1	deleterious	0.36	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.43	medium_impact	1.2	medium_impact	0.71	0.85	67.84	19.4	0.69	P	0.95	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7921	7921	C	A	MI.5906	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	336	112	D	E	gaC/gaA	8.59	1	0	probably_damaging	1	neutral	0.72	neutral	1.65	neutral	-1.68	deleterious	-3.85	medium_impact	2.46	0.43	damaging	0.22	damaging	4.20	23.90	deleterious	0.58	0.65	0.59	disease	0.74	disease	0.57	disease	0.64	disease	3	1	deleterious	0.36	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.43	medium_impact	1.2	medium_impact	0.71	0.85	67.84	19.4	0.7	P	0.95	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7922	7922	T	A	MI.5907	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	337	113	Y	N	Tac/Aac	-2.24	0	0	benign	0.43	neutral	0.31	neutral	1.91	neutral	-1.68	deleterious	-8.33	low_impact	1.77	0.58	damaging	0.4	neutral	2.68	20.70	deleterious	0.6	0.65	0.67	disease	0.9	disease	0.56	disease	0.69	disease	4	0.64	neutral	0.44	neutral	-6	neutral	0.64	deleterious	-0.61	medium_impact	0.01	medium_impact	0.55	medium_impact	0.23	0.8	69.6	18.98	0.32	N	0.99	polymorphism	0.54	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7922	7922	T	G	MI.5908	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	337	113	Y	D	Tac/Gac	-2.24	0	0	possibly_damaging	0.6	neutral	0.21	neutral	1.93	neutral	-1.15	deleterious	-9.16	low_impact	1.75	0.53	damaging	0.33	neutral	3.82	23.40	deleterious	0.53	0.6	0.73	disease	0.88	disease	0.61	disease	0.72	disease	4	0.79	neutral	0.31	neutral	-3	neutral	0.74	deleterious	-0.89	medium_impact	-0.11	medium_impact	0.54	medium_impact	0.36	0.8	69.6	18.98	0.33	N	0.99	polymorphism	0.62	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7922	7922	T	C	MI.5909	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	337	113	Y	H	Tac/Cac	-2.24	0	0	benign	0.01	neutral	0.47	neutral	1.9	neutral	-2.1	deleterious	-4.76	low_impact	1.8	0.66	neutral	0.34	neutral	1.69	14.37	neutral	0.66	0.7	0.75	disease	0.69	disease	0.46	neutral	0.47	neutral	1	0.51	neutral	0.73	deleterious	-6	neutral	0.30	neutral	1.14	medium_impact	0.18	medium_impact	0.58	medium_impact	0.23	0.8	69.6	18.98	0.27	N	0.94	polymorphism	0.93	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8803	8803	A	G	MI.591	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	277	93	T	A	Aca/Gca	-5.89	0	0.01	probably_damaging	0.99	deleterious	0.03	neutral	4.24	neutral	-1.13	deleterious	-4.24	medium_impact	2.43	0.81	neutral	0.58	neutral	3.42	23.00	deleterious	0.48	0.65	0.32	neutral	0.37	neutral	0.5	neutral	0.4	neutral	2	1	deleterious	0.02	neutral	5	deleterious	0.68	deleterious	-2.65	low_impact	-0.56	medium_impact	0.99	medium_impact	0.50	0.9	46.02	8.31	0.4	N	0.63	polymorphism	0.87	0.12	.	.	.	.	.	head/neck tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7923	7923	A	G	MI.5910	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	338	113	Y	C	tAc/tGc	5.83	1	0	probably_damaging	0.91	neutral	0.16	neutral	1.89	neutral	-2.78	deleterious	-8.06	medium_impact	2.74	0.59	damaging	0.29	neutral	3.58	23.20	deleterious	0.58	0.65	0.78	disease	0.9	disease	0.58	disease	0.69	disease	4	0.95	neutral	0.13	neutral	1	deleterious	0.82	deleterious	-1.66	low_impact	-0.19	medium_impact	1.46	medium_impact	0.12	0.8	69.6	18.98	0.46	N	0.96	disease_causing	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7923	7923	A	T	MI.5911	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	338	113	Y	F	tAc/tTc	5.83	1	0	benign	0.19	neutral	0.86	neutral	2.1	neutral	0.86	deleterious	-2.82	neutral_impact	-0.16	0.71	neutral	0.84	neutral	-0.15	1.40	neutral	0.57	0.65	0.39	neutral	0.1	neutral	0.17	neutral	0.29	neutral	4	0.09	neutral	0.84	deleterious	-6	neutral	0.37	neutral	-0.13	medium_impact	0.64	medium_impact	-1.26	low_impact	0.28	0.8	69.6	18.98	0.49	P	0.87	disease_causing	0.78	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7923	7923	A	C	MI.5912	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	338	113	Y	S	tAc/tCc	5.83	1	0	possibly_damaging	0.52	neutral	0.42	neutral	1.94	neutral	-0.87	deleterious	-8.12	low_impact	1.52	0.58	damaging	0.46	neutral	3.38	22.90	deleterious	0.54	0.6	0.44	neutral	0.79	disease	0.48	neutral	0.56	disease	1	0.57	neutral	0.45	neutral	-3	neutral	0.61	deleterious	-0.75	medium_impact	0.13	medium_impact	0.32	medium_impact	0.23	0.8	69.6	18.98	0.49	P	0.99	disease_causing	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7925	7925	G	T	MI.5913	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	340	114	G	C	Ggc/Tgc	-1.55	0	0	probably_damaging	0.99	neutral	0.09	neutral	1.78	deleterious	-5.34	neutral	-1.59	low_impact	1.84	0.63	neutral	0.44	neutral	4.13	23.80	deleterious	0.2	0.45	0.79	disease	0.65	disease	0.19	neutral	0.4	neutral	2	1	deleterious	0.05	neutral	-2	neutral	0.78	deleterious	-2.58	low_impact	-0.35	medium_impact	0.62	medium_impact	0.35	0.8	29.07	71.47	0.42	N	0.75	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7925	7925	G	C	MI.5914	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	340	114	G	R	Ggc/Cgc	-1.55	0	0	probably_damaging	0.94	neutral	0.4	neutral	1.83	neutral	-1.89	neutral	1.15	low_impact	1.64	0.65	neutral	0.45	neutral	2.81	21.40	deleterious	0.33	0.5	0.53	disease	0.65	disease	0.37	neutral	0.41	neutral	2	0.95	neutral	0.23	neutral	-2	neutral	0.74	deleterious	-1.83	low_impact	0.11	medium_impact	0.43	medium_impact	0.75	0.85	29.07	71.47	0.37	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7925	7925	G	A	MI.5915	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	340	114	G	S	Ggc/Agc	-1.55	0	0	possibly_damaging	0.82	neutral	0.85	neutral	1.86	neutral	-1.4	neutral	1.39	neutral_impact	0.48	0.79	neutral	0.82	neutral	2.68	20.70	deleterious	0.42	0.55	0.44	neutral	0.22	neutral	0.11	neutral	0.43	neutral	1	0.79	neutral	0.52	deleterious	-3	neutral	0.62	deleterious	-1.33	low_impact	0.62	medium_impact	-0.66	medium_impact	0.73	0.85	29.07	71.47	0.27	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7926	7926	G	C	MI.5916	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	341	114	G	A	gGc/gCc	0.52	0.03	0	possibly_damaging	0.73	neutral	0.64	neutral	1.85	neutral	-1.25	neutral	0.54	neutral_impact	0.56	0.75	neutral	0.76	neutral	1.71	14.48	neutral	0.43	0.55	0.42	neutral	0.28	neutral	0.19	neutral	0.45	neutral	1	0.68	neutral	0.46	neutral	-3	neutral	0.60	deleterious	-1.12	low_impact	0.34	medium_impact	-0.58	medium_impact	0.59	0.8	29.07	71.47	0.38	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7926	7926	G	A	MI.5917	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	341	114	G	D	gGc/gAc	0.52	0.03	0	possibly_damaging	0.82	neutral	0.83	neutral	1.88	neutral	-0.27	neutral	1.83	neutral_impact	-0.13	0.77	neutral	0.94	neutral	2.26	17.87	deleterious	0.31	0.45	0.57	disease	0.55	disease	0.31	neutral	0.24	neutral	5	0.79	neutral	0.51	deleterious	-3	neutral	0.68	deleterious	-1.33	low_impact	0.59	medium_impact	-1.23	low_impact	0.53	0.8	29.07	71.47	0.23	N	0.44	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7926	7926	G	T	MI.5918	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	341	114	G	V	gGc/gTc	0.52	0.03	0	probably_damaging	0.97	neutral	0.39	neutral	1.84	neutral	-2.87	neutral	-0.25	neutral_impact	0.52	0.78	neutral	0.79	neutral	2.66	20.50	deleterious	0.28	0.45	0.28	neutral	0.47	neutral	0.25	neutral	0.45	neutral	1	0.97	neutral	0.21	neutral	-2	neutral	0.65	deleterious	-2.13	low_impact	0.1	medium_impact	-0.62	medium_impact	0.35	0.8	29.07	71.47	0.35	N	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7928	7928	G	C	MI.5919	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	343	115	G	R	Gga/Cga	-0.4	0.02	0	probably_damaging	0.94	neutral	0.63	neutral	2.01	neutral	0.14	neutral	-0.61	low_impact	1.75	0.63	neutral	0.44	neutral	3.98	23.60	deleterious	0.52	0.6	0.39	neutral	0.76	disease	0.64	disease	0.68	disease	4	0.93	neutral	0.35	neutral	-2	neutral	0.74	deleterious	-1.83	low_impact	0.33	medium_impact	0.54	medium_impact	0.84	0.9	27.75	74.03	0.27	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8804	8804	C	A	MI.592	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	278	93	T	K	aCa/aAa	6.84	1	0	probably_damaging	1	deleterious	0.01	neutral	4.13	deleterious	-3.08	deleterious	-5.32	high_impact	4.07	0.62	neutral	0.39	neutral	4.32	24.00	deleterious	0.21	0.65	0.83	disease	0.71	disease	0.74	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.6	low_impact	-0.84	medium_impact	2.39	high_impact	0.65	0.9	46.02	8.31	0.54	P	1.00	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7928	7928	G	T	MI.5920	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	343	115	G	W	Gga/Tga	-0.4	0.02	0	probably_damaging	0.99	neutral	0.22	neutral	1.93	deleterious	-3.7	deleterious	-3.02	medium_impact	2.56	0.68	neutral	0.46	neutral	4.56	24.40	deleterious	0.33	0.5	0.88	disease	0.76	disease	0.63	disease	0.73	disease	5	0.99	deleterious	0.12	neutral	1	deleterious	0.83	deleterious	-2.58	low_impact	-0.1	medium_impact	1.3	medium_impact	0.43	0.8	27.75	74.03	0.27	N	0.48	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7929	7929	G	A	MI.5921	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	344	115	G	E	gGa/gAa	1.68	0.96	0	possibly_damaging	0.82	neutral	0.85	neutral	2.08	neutral	1.12	neutral	2	neutral_impact	0.77	0.82	neutral	0.86	neutral	2.53	19.68	deleterious	0.53	0.6	0.29	neutral	0.63	disease	0.39	neutral	0.23	neutral	6	0.8	neutral	0.52	deleterious	-3	neutral	0.67	deleterious	-1.33	low_impact	0.62	medium_impact	-0.38	medium_impact	0.43	0.8	27.75	74.03	0.28	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7929	7929	G	C	MI.5922	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	344	115	G	A	gGa/gCa	1.68	0.96	0	possibly_damaging	0.5	neutral	0.95	neutral	2.03	neutral	0.55	neutral	-0.97	low_impact	1.41	0.74	neutral	0.78	neutral	2.72	20.90	deleterious	0.51	0.6	0.35	neutral	0.37	neutral	0.37	neutral	0.46	neutral	1	0.45	neutral	0.73	deleterious	-3	neutral	0.52	deleterious	-0.72	medium_impact	0.91	medium_impact	0.22	medium_impact	0.57	0.8	27.75	74.03	0.34	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7929	7929	G	T	MI.5923	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	344	115	G	V	gGa/gTa	1.68	0.96	0	probably_damaging	0.94	neutral	0.66	neutral	1.99	neutral	-0.31	neutral	-2.04	low_impact	1.52	0.73	neutral	0.6	neutral	3.74	23.30	deleterious	0.44	0.55	0.54	disease	0.6	disease	0.53	disease	0.59	disease	2	0.93	neutral	0.36	neutral	-2	neutral	0.73	deleterious	-1.83	low_impact	0.36	medium_impact	0.32	medium_impact	0.37	0.8	27.75	74.03	0.3	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7931	7931	C	G	MI.5924	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	346	116	L	V	Cta/Gta	-1.55	0	0	probably_damaging	0.99	neutral	0.52	neutral	2.02	neutral	0.1	neutral	-2.49	low_impact	1.07	0.37	damaging	0.08	damaging	2.32	18.30	deleterious	0.56	0.6	0.42	neutral	0.18	neutral	0.22	neutral	0.31	neutral	4	0.99	deleterious	0.27	neutral	-2	neutral	0.68	deleterious	-2.58	low_impact	0.22	medium_impact	-0.1	medium_impact	0.67	0.85	68.72	19.34	0.46	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7931	7931	C	A	MI.5925	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	346	116	L	M	Cta/Ata	-1.55	0	0	probably_damaging	1	neutral	0.22	neutral	1.78	neutral	-2.11	neutral	-1.47	low_impact	1.32	0.4	damaging	0.25	damaging	2.69	20.70	deleterious	0.33	0.5	0.67	disease	0.25	neutral	0.23	neutral	0.56	disease	1	1	deleterious	0.11	neutral	-2	neutral	0.73	deleterious	-3.52	low_impact	-0.1	medium_impact	0.13	medium_impact	0.77	0.85	68.72	19.34	0.54	P	0.78	polymorphism	1	0.02	rs28705169	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7932	7932	T	G	MI.5926	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	347	116	L	R	cTa/cGa	-2.01	0	0	probably_damaging	1	neutral	0.35	neutral	1.73	deleterious	-3.56	deleterious	-5.59	medium_impact	3.31	0.16	damaging	0.02	damaging	4.23	23.90	deleterious	0.4	0.5	0.78	disease	0.81	disease	0.66	disease	0.72	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	0.06	medium_impact	2	medium_impact	0.54	0.8	68.72	19.34	0.75	P	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7932	7932	T	C	MI.5927	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	347	116	L	P	cTa/cCa	-2.01	0	0	probably_damaging	1	neutral	0.22	neutral	1.72	deleterious	-4.25	deleterious	-6.46	medium_impact	2.27	0.11	damaging	0.03	damaging	3.99	23.60	deleterious	0.38	0.5	0.84	disease	0.79	disease	0.57	disease	0.68	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.89	deleterious	-3.52	low_impact	-0.1	medium_impact	1.02	medium_impact	0.48	0.8	68.72	19.34	0.72	P	0.99	polymorphism	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7932	7932	T	A	MI.5928	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	347	116	L	Q	cTa/cAa	-2.01	0	0	probably_damaging	1	neutral	0.31	neutral	1.73	deleterious	-3.62	deleterious	-5.45	medium_impact	2.62	0.32	damaging	0.05	damaging	4.26	23.90	deleterious	0.46	0.55	0.8	disease	0.56	disease	0.57	disease	0.65	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	0.01	medium_impact	1.35	medium_impact	0.58	0.8	68.72	19.34	0.51	P	0.95	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7934	7934	A	T	MI.5929	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	349	117	I	F	Atc/Ttc	-10.08	0	0	benign	0.38	neutral	0.7	neutral	1.98	neutral	-1.15	neutral	-0.47	neutral_impact	0.2	0.71	neutral	0.69	neutral	2.21	17.59	deleterious	0.53	0.6	0.4	neutral	0.61	disease	0.49	neutral	0.45	neutral	1	0.29	neutral	0.66	deleterious	-6	neutral	0.41	neutral	-0.52	medium_impact	0.41	medium_impact	-0.92	medium_impact	0.48	0.8	32.16	56.45	0.24	N	0.32	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8804	8804	C	T	MI.593	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	278	93	T	M	aCa/aTa	6.84	1	0	probably_damaging	1	deleterious	0	neutral	4.14	neutral	-2.84	deleterious	-5.32	high_impact	4.42	0.7	neutral	0.53	neutral	3.94	23.50	deleterious	0.32	0.65	0.91	disease	0.63	disease	0.7	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.6	low_impact	-1.4	low_impact	2.69	high_impact	0.70	0.9	46.02	8.31	0.56	P	0.98	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7934	7934	A	G	MI.5930	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	349	117	I	V	Atc/Gtc	-10.08	0	0	benign	0	neutral	0.5	neutral	2.01	neutral	0.24	neutral	0.57	neutral_impact	0.38	0.85	neutral	0.93	neutral	-0.04	2.24	deleterious	0.67	0.7	0.15	neutral	0.27	neutral	0.46	neutral	0.37	neutral	3	0.49	neutral	0.75	deleterious	-6	neutral	0.09	neutral	2.08	high_impact	0.21	medium_impact	-0.75	medium_impact	0.52	0.8	32.16	56.45	0.3	N	0.34	polymorphism	1	0.00	rs374261450	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7934	7934	A	C	MI.5931	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	349	117	I	L	Atc/Ctc	-10.08	0	0	benign	0.04	neutral	0.65	neutral	2.01	neutral	0.32	neutral	-0.01	neutral_impact	0.16	0.69	neutral	0.63	neutral	0.67	8.63	deleterious	0.52	0.6	0.22	neutral	0.46	neutral	0.44	neutral	0.43	neutral	1	0.29	neutral	0.81	deleterious	-6	neutral	0.14	neutral	0.57	medium_impact	0.35	medium_impact	-0.96	medium_impact	0.42	0.8	32.16	56.45	0.36	N	0.33	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7935	7935	T	A	MI.5932	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	350	117	I	N	aTc/aAc	-0.86	0	0	possibly_damaging	0.8	neutral	0.31	neutral	2.04	neutral	0.87	neutral	1.69	neutral_impact	-0.41	0.74	neutral	0.94	neutral	2.99	22.20	deleterious	0.49	0.55	0.29	neutral	0.73	disease	0.38	neutral	0.22	neutral	6	0.83	neutral	0.26	neutral	-3	neutral	0.59	deleterious	-1.28	low_impact	0.01	medium_impact	-1.49	low_impact	0.55	0.8	32.16	56.45	0.32	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7935	7935	T	G	MI.5933	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	350	117	I	S	aTc/aGc	-0.86	0	0	possibly_damaging	0.46	neutral	0.4	neutral	2.11	neutral	1.8	neutral	2.31	neutral_impact	-1.58	0.75	neutral	0.95	neutral	0.64	8.46	deleterious	0.38	0.5	0.2	neutral	0.49	neutral	0.23	neutral	0.28	neutral	4	0.56	neutral	0.47	deleterious	-3	neutral	0.26	neutral	-0.66	medium_impact	0.11	medium_impact	-2.59	low_impact	0.42	0.8	32.16	56.45	0.33	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7935	7935	T	C	MI.5934	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	350	117	I	T	aTc/aCc	-0.86	0	0	benign	0.2	neutral	0.39	neutral	2.05	neutral	1.03	neutral	2.06	neutral_impact	-0.92	0.76	neutral	0.94	neutral	0.00	2.55	deleterious	0.6	0.65	0.13	neutral	0.37	neutral	0.23	neutral	0.4	neutral	2	0.53	neutral	0.6	deleterious	-6	neutral	0.16	neutral	-0.16	medium_impact	0.1	medium_impact	-1.97	low_impact	0.42	0.8	32.16	56.45	0.31	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7936	7936	C	G	MI.5935	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	351	117	I	M	atC/atG	-2.48	0	0	possibly_damaging	0.66	neutral	0.22	neutral	1.98	neutral	-0.87	neutral	0.62	neutral_impact	-0.09	0.72	neutral	0.9	neutral	2.00	16.19	deleterious	0.64	0.7	0.39	neutral	0.35	neutral	0.19	neutral	0.44	neutral	1	0.81	neutral	0.28	neutral	-3	neutral	0.40	neutral	-0.99	medium_impact	-0.1	medium_impact	-1.19	low_impact	0.72	0.85	32.16	56.45	0.53	N	0.52	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7936	7936	C	A	MI.5936	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	351	117	I	M	atC/atA	-2.48	0	0	possibly_damaging	0.66	neutral	0.22	neutral	1.98	neutral	-0.87	neutral	0.62	neutral_impact	-0.09	0.72	neutral	0.9	neutral	2.41	18.91	deleterious	0.64	0.7	0.39	neutral	0.35	neutral	0.19	neutral	0.44	neutral	1	0.81	neutral	0.28	neutral	-3	neutral	0.40	neutral	-0.99	medium_impact	-0.1	medium_impact	-1.19	low_impact	0.72	0.85	32.16	56.45	0.53	N	0.52	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7937	7937	T	C	MI.5937	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	352	118	F	L	Ttc/Ctc	-2.71	0	0	probably_damaging	1	neutral	0.67	neutral	1.58	neutral	-1.78	deleterious	-5.56	medium_impact	3.04	0.32	damaging	0.54	neutral	4.14	23.80	deleterious	0.46	0.55	0.46	neutral	0.84	disease	0.72	disease	0.69	disease	4	0.99	deleterious	0.34	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.38	medium_impact	1.75	medium_impact	0.50	0.8	67.84	19.52	0.67	P	0.81	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7937	7937	T	A	MI.5938	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	352	118	F	I	Ttc/Atc	-2.71	0	0	probably_damaging	1	neutral	0.4	neutral	1.5	neutral	-2.5	deleterious	-5.63	medium_impact	2.36	0.32	damaging	0.52	neutral	4.46	24.20	deleterious	0.37	0.5	0.54	disease	0.81	disease	0.72	disease	0.58	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	0.11	medium_impact	1.11	medium_impact	0.44	0.8	67.84	19.52	0.64	P	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7937	7937	T	G	MI.5939	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	352	118	F	V	Ttc/Gtc	-2.71	0	0	probably_damaging	1	neutral	0.5	neutral	1.47	neutral	-2.82	deleterious	-6.62	medium_impact	2.83	0.32	damaging	0.43	neutral	4.16	23.80	deleterious	0.33	0.5	0.39	neutral	0.88	disease	0.79	disease	0.7	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.21	medium_impact	1.55	medium_impact	0.42	0.8	67.84	19.52	0.67	P	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8806	8806	C	G	MI.594	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	280	94	P	A	Cca/Gca	-8.43	0	0	probably_damaging	1	neutral	0.13	neutral	3.67	neutral	-1.42	deleterious	-7.2	medium_impact	2.19	0.78	neutral	0.22	damaging	3.03	22.30	deleterious	0.3	0.65	0.64	disease	0.37	neutral	0.54	disease	0.61	disease	2	1	deleterious	0.07	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.18	medium_impact	0.78	medium_impact	0.86	0.9	49.56	8.53	0.3	N	0.79	polymorphism	0.82	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7938	7938	T	C	MI.5940	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	353	118	F	S	tTc/tCc	4.67	1	0	probably_damaging	1	neutral	0.44	neutral	1.4	deleterious	-4.46	deleterious	-7.69	high_impact	4.08	0.37	damaging	0.52	neutral	4.35	24.10	deleterious	0.28	0.45	0.65	disease	0.85	disease	0.79	disease	0.69	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.15	medium_impact	2.72	high_impact	0.31	0.8	67.84	19.52	0.77	P	0.96	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7938	7938	T	A	MI.5941	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	353	118	F	Y	tTc/tAc	4.67	1	0	probably_damaging	1	neutral	1	neutral	1.47	neutral	-2.84	deleterious	-2.89	low_impact	1.87	0.35	damaging	0.41	neutral	4.33	24.00	deleterious	0.34	0.5	0.41	neutral	0.76	disease	0.71	disease	0.57	disease	1	0.99	deleterious	0.5	deleterious	-2	neutral	0.79	deleterious	-3.52	low_impact	1.86	high_impact	0.65	medium_impact	0.56	0.8	67.84	19.52	0.72	P	0.76	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7938	7938	T	G	MI.5942	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	353	118	F	C	tTc/tGc	4.67	1	0	probably_damaging	1	neutral	0.18	neutral	1.37	deleterious	-5.94	deleterious	-7.66	high_impact	4.08	0.3	damaging	0.44	neutral	4.19	23.80	deleterious	0.28	0.45	0.83	disease	0.86	disease	0.8	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.16	medium_impact	2.72	high_impact	0.25	0.8	67.84	19.52	0.76	P	1.00	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7939	7939	C	A	MI.5943	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	354	118	F	L	ttC/ttA	5.83	1	0	probably_damaging	1	neutral	0.67	neutral	1.58	neutral	-1.78	deleterious	-5.56	medium_impact	3.04	0.32	damaging	0.54	neutral	4.75	24.70	deleterious	0.46	0.55	0.46	neutral	0.84	disease	0.72	disease	0.69	disease	4	0.99	deleterious	0.34	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.38	medium_impact	1.75	medium_impact	0.50	0.8	67.84	19.52	0.81	P	0.81	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7939	7939	C	G	MI.5944	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	354	118	F	L	ttC/ttG	5.83	1	0	probably_damaging	1	neutral	0.67	neutral	1.58	neutral	-1.78	deleterious	-5.56	medium_impact	3.04	0.32	damaging	0.54	neutral	4.44	24.20	deleterious	0.46	0.55	0.46	neutral	0.84	disease	0.72	disease	0.69	disease	4	0.99	deleterious	0.34	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.38	medium_impact	1.75	medium_impact	0.50	0.8	67.84	19.52	0.81	P	0.81	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7940	7940	A	G	MI.5945	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	355	119	N	D	Aac/Gac	-3.17	0	0	probably_damaging	0.99	neutral	1	neutral	2.47	neutral	2.44	neutral	4.57	neutral_impact	-2.04	0.76	neutral	0.93	neutral	1.15	11.49	neutral	0.76	0.8	0.21	neutral	0.03	neutral	0.28	neutral	0.15	neutral	7	0.99	deleterious	0.51	deleterious	-2	neutral	0.64	deleterious	-2.58	low_impact	1.86	high_impact	-3.02	low_impact	0.55	0.8	28.63	71.46	0.28	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7940	7940	A	C	MI.5946	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	355	119	N	H	Aac/Cac	-3.17	0	0	probably_damaging	1	neutral	0.38	neutral	1.9	neutral	-2.07	neutral	-2.07	medium_impact	2.04	0.75	neutral	0.55	neutral	3.12	22.60	deleterious	0.51	0.6	0.14	neutral	0.29	neutral	0.71	disease	0.39	neutral	2	1	deleterious	0.19	neutral	1	deleterious	0.70	deleterious	-3.52	low_impact	0.09	medium_impact	0.81	medium_impact	0.33	0.8	28.63	71.46	0.33	N	0.44	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7940	7940	A	T	MI.5947	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	355	119	N	Y	Aac/Tac	-3.17	0	0	probably_damaging	1	neutral	0.92	neutral	1.89	deleterious	-3.15	deleterious	-4.09	low_impact	1	0.72	neutral	0.63	neutral	3.77	23.40	deleterious	0.35	0.5	0.51	disease	0.43	neutral	0.71	disease	0.51	disease	0	1	deleterious	0.46	neutral	-2	neutral	0.78	deleterious	-3.52	low_impact	0.79	medium_impact	-0.17	medium_impact	0.46	0.8	28.63	71.46	0.23	N	0.86	polymorphism	0.97	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7941	7941	A	G	MI.5948	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	356	119	N	S	aAc/aGc	6.06	1	0	probably_damaging	0.99	neutral	0.59	neutral	1.95	neutral	-0.68	neutral	-1.12	low_impact	1.14	0.75	neutral	0.65	neutral	3.15	22.60	deleterious	0.7	0.75	0.2	neutral	0.28	neutral	0.58	disease	0.39	neutral	2	0.99	deleterious	0.3	neutral	-2	neutral	0.71	deleterious	-2.58	low_impact	0.29	medium_impact	-0.04	medium_impact	0.25	0.8	28.63	71.46	0.53	P	0.21	polymorphism	0.57	0.02	.	.	.	.	.	.	COSM5651997	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7941	7941	A	C	MI.5949	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	356	119	N	T	aAc/aCc	6.06	1	0	probably_damaging	1	neutral	0.43	neutral	1.92	neutral	-1.33	neutral	-2.11	low_impact	1.1	0.69	neutral	0.63	neutral	3.45	23.00	deleterious	0.56	0.6	0.17	neutral	0.29	neutral	0.55	disease	0.38	neutral	2	1	deleterious	0.22	neutral	-2	neutral	0.69	deleterious	-3.52	low_impact	0.14	medium_impact	-0.07	medium_impact	0.34	0.8	28.63	71.46	0.54	P	0.36	disease_causing	0.71	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8806	8806	C	A	MI.595	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	280	94	P	T	Cca/Aca	-8.43	0	0	probably_damaging	1	neutral	0.23	neutral	3.63	neutral	-2.55	deleterious	-7.21	medium_impact	2.44	0.74	neutral	0.17	damaging	3.67	23.20	deleterious	0.28	0.65	0.74	disease	0.55	disease	0.49	neutral	0.44	neutral	1	1	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.01	medium_impact	0.99	medium_impact	0.78	0.9	49.56	8.53	0.28	N	0.93	polymorphism	0.75	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7941	7941	A	T	MI.5950	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	356	119	N	I	aAc/aTc	6.06	1	0	probably_damaging	1	neutral	0.29	neutral	1.89	neutral	-2.99	deleterious	-4.13	low_impact	1.23	0.73	neutral	0.66	neutral	4.02	23.60	deleterious	0.29	0.45	0.47	neutral	0.53	disease	0.65	disease	0.66	disease	3	1	deleterious	0.15	neutral	-2	neutral	0.77	deleterious	-3.52	low_impact	-0.01	medium_impact	0.05	medium_impact	0.35	0.8	28.63	71.46	0.54	P	0.88	disease_causing	0.88	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7942	7942	C	G	MI.5951	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	357	119	N	K	aaC/aaG	8.59	1	0	probably_damaging	1	neutral	0.31	neutral	1.95	neutral	-0.66	neutral	-2.1	medium_impact	2.04	0.69	neutral	0.53	neutral	4.06	23.70	deleterious	0.78	0.8	0.13	neutral	0.44	neutral	0.72	disease	0.44	neutral	1	1	deleterious	0.16	neutral	1	deleterious	0.70	deleterious	-3.52	low_impact	0.01	medium_impact	0.81	medium_impact	0.57	0.8	28.63	71.46	0.56	P	0.65	disease_causing	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7942	7942	C	A	MI.5952	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	357	119	N	K	aaC/aaA	8.59	1	0	probably_damaging	1	neutral	0.31	neutral	1.95	neutral	-0.66	neutral	-2.1	medium_impact	2.04	0.69	neutral	0.53	neutral	4.48	24.20	deleterious	0.78	0.8	0.13	neutral	0.44	neutral	0.72	disease	0.44	neutral	1	1	deleterious	0.16	neutral	1	deleterious	0.70	deleterious	-3.52	low_impact	0.01	medium_impact	0.81	medium_impact	0.57	0.8	28.63	71.46	0.57	P	0.65	disease_causing	0.91	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7943	7943	T	C	MI.5953	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	358	120	S	P	Tcc/Ccc	0.06	0.96	0	probably_damaging	1	neutral	0.2	neutral	1.41	deleterious	-4.48	deleterious	-4.83	high_impact	4.59	0.35	damaging	0.4	neutral	4.12	23.80	deleterious	0.27	0.45	0.7	disease	0.85	disease	0.75	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.13	medium_impact	3.2	high_impact	0.66	0.8	69.16	19.57	0.75	P	0.99	disease_causing	0.91	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7943	7943	T	A	MI.5954	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	358	120	S	T	Tcc/Acc	0.06	0.96	0	probably_damaging	0.99	neutral	0.38	neutral	1.49	neutral	-2.77	deleterious	-2.88	high_impact	3.62	0.38	damaging	0.4	neutral	4.08	23.70	deleterious	0.36	0.5	0.49	neutral	0.71	disease	0.66	disease	0.54	disease	1	0.99	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-2.58	low_impact	0.09	medium_impact	2.29	high_impact	0.80	0.85	69.16	19.57	0.67	P	0.53	disease_causing	0.62	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7943	7943	T	G	MI.5955	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	358	120	S	A	Tcc/Gcc	0.06	0.96	0	probably_damaging	0.99	neutral	0.49	neutral	1.59	neutral	-1.76	deleterious	-2.73	medium_impact	2.9	0.53	damaging	0.73	neutral	2.76	21.10	deleterious	0.41	0.5	0.39	neutral	0.54	disease	0.51	disease	0.16	neutral	7	0.99	deleterious	0.25	neutral	1	deleterious	0.75	deleterious	-2.58	low_impact	0.2	medium_impact	1.61	medium_impact	0.76	0.85	69.16	19.57	0.48	N	0.36	polymorphism	0.67	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7944	7944	C	A	MI.5956	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	359	120	S	Y	tCc/tAc	5.6	1	0	probably_damaging	1	neutral	1	neutral	1.39	deleterious	-5.6	deleterious	-5.8	high_impact	4.25	0.35	damaging	0.33	neutral	4.19	23.80	deleterious	0.24	0.45	0.82	disease	0.86	disease	0.78	disease	0.69	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.86	deleterious	-3.52	low_impact	1.86	high_impact	2.88	high_impact	0.74	0.85	69.16	19.57	0.73	P	1.00	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7944	7944	C	T	MI.5957	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	359	120	S	F	tCc/tTc	5.6	1	0	probably_damaging	1	neutral	0.7	neutral	1.39	deleterious	-5.4	deleterious	-5.8	high_impact	4.25	0.33	damaging	0.32	neutral	4.36	24.10	deleterious	0.21	0.45	0.81	disease	0.88	disease	0.78	disease	0.7	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.41	medium_impact	2.88	high_impact	0.43	0.8	69.16	19.57	0.76	P	0.99	disease_causing	1	0.25	.	.	.	.	.	.	COSM1331630	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7944	7944	C	G	MI.5958	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	359	120	S	C	tCc/tGc	5.6	1	0	probably_damaging	1	neutral	0.17	neutral	1.4	deleterious	-5.17	deleterious	-4.79	medium_impact	3.27	0.37	damaging	0.37	neutral	3.69	23.30	deleterious	0.27	0.45	0.47	neutral	0.82	disease	0.74	disease	0.69	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	-0.18	medium_impact	1.96	medium_impact	0.65	0.8	69.16	19.57	0.72	P	0.91	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7946	7946	T	A	MI.5959	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	361	121	Y	N	Tac/Aac	-11.24	0	0	probably_damaging	1	neutral	0.11	neutral	1.36	deleterious	-4.98	deleterious	-8.88	medium_impact	2.44	0.17	damaging	0.02	damaging	4.13	23.80	deleterious	0.34	0.5	0.42	neutral	0.87	disease	0.76	disease	0.68	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	-0.3	medium_impact	1.18	medium_impact	0.26	0.8	68.28	19.64	0.6	P	0.99	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8806	8806	C	T	MI.596	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	280	94	P	S	Cca/Tca	-8.43	0	0	probably_damaging	1	neutral	0.43	neutral	3.66	neutral	-2.17	deleterious	-7.2	low_impact	1.82	0.73	neutral	0.19	damaging	3.87	23.50	deleterious	0.42	0.65	0.59	disease	0.35	neutral	0.47	neutral	0.57	disease	1	1	deleterious	0.22	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.22	medium_impact	0.46	medium_impact	0.33	0.9	49.56	8.53	0.26	N	0.82	polymorphism	0.74	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7946	7946	T	C	MI.5960	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	361	121	Y	H	Tac/Cac	-11.24	0	0	probably_damaging	1	neutral	0.15	neutral	1.38	deleterious	-4.38	deleterious	-4.93	high_impact	3.84	0.12	damaging	0.02	damaging	3.67	23.30	deleterious	0.52	0.6	0.63	disease	0.84	disease	0.74	disease	0.7	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	-0.21	medium_impact	2.5	high_impact	0.36	0.8	68.28	19.64	0.68	P	0.94	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7946	7946	T	G	MI.5961	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	361	121	Y	D	Tac/Gac	-11.24	0	0	probably_damaging	1	neutral	0.18	neutral	1.35	deleterious	-5.65	deleterious	-9.86	high_impact	4.38	0.2	damaging	0.02	damaging	4.08	23.70	deleterious	0.22	0.45	0.47	neutral	0.88	disease	0.79	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	-0.16	medium_impact	3	high_impact	0.32	0.8	68.28	19.64	0.52	P	0.99	polymorphism	0.99	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7947	7947	A	C	MI.5962	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	362	121	Y	S	tAc/tCc	5.83	1	0	probably_damaging	1	neutral	0.29	neutral	1.38	deleterious	-4.42	deleterious	-8.87	high_impact	3.58	0.13	damaging	0.02	damaging	3.84	23.40	deleterious	0.27	0.45	0.44	neutral	0.85	disease	0.76	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	-0.01	medium_impact	2.25	high_impact	0.23	0.8	68.28	19.64	0.82	P	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7947	7947	A	T	MI.5963	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	362	121	Y	F	tAc/tTc	5.83	1	0	probably_damaging	0.99	neutral	0.4	neutral	1.55	neutral	-1.85	deleterious	-3.94	low_impact	1.88	0.16	damaging	0.03	damaging	3.63	23.20	deleterious	0.4	0.5	0.61	disease	0.76	disease	0.56	disease	0.28	neutral	4	0.99	deleterious	0.21	neutral	-2	neutral	0.82	deleterious	-2.58	low_impact	0.11	medium_impact	0.66	medium_impact	0.36	0.8	68.28	19.64	0.87	P	0.87	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7947	7947	A	G	MI.5964	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	362	121	Y	C	tAc/tGc	5.83	1	0	probably_damaging	1	neutral	0.05	neutral	1.35	deleterious	-6.12	deleterious	-8.88	high_impact	4.38	0.14	damaging	0.02	damaging	3.67	23.30	deleterious	0.37	0.5	0.81	disease	0.87	disease	0.81	disease	0.69	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.5	medium_impact	3	high_impact	0.15	0.8	68.28	19.64	0.83	P	0.96	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7949	7949	A	G	MI.5965	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	364	122	M	V	Ata/Gta	-5.7	0	0	probably_damaging	0.94	neutral	0.45	neutral	1.83	neutral	-0.97	deleterious	-3.72	medium_impact	3.34	0.14	damaging	0.03	damaging	2.72	20.90	deleterious	0.49	0.55	0.23	neutral	0.84	disease	0.78	disease	0.69	disease	4	0.94	neutral	0.26	neutral	1	deleterious	0.74	deleterious	-1.83	low_impact	0.16	medium_impact	2.03	high_impact	0.51	0.8	70.93	16.47	0.71	P	0.89	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7949	7949	A	T	MI.5966	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	364	122	M	L	Ata/Tta	-5.7	0	0	probably_damaging	0.91	neutral	0.61	neutral	1.9	neutral	-0.54	deleterious	-2.81	medium_impact	2.17	0.17	damaging	0.05	damaging	3.27	22.80	deleterious	0.35	0.5	0.25	neutral	0.82	disease	0.68	disease	0.53	disease	1	0.9	neutral	0.35	neutral	1	deleterious	0.67	deleterious	-1.66	low_impact	0.31	medium_impact	0.93	medium_impact	0.54	0.8	70.93	16.47	0.72	P	0.70	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7949	7949	A	C	MI.5967	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	364	122	M	L	Ata/Cta	-5.7	0	0	probably_damaging	0.91	neutral	0.61	neutral	1.9	neutral	-0.54	deleterious	-2.81	medium_impact	2.17	0.17	damaging	0.05	damaging	3.24	22.80	deleterious	0.35	0.5	0.25	neutral	0.82	disease	0.68	disease	0.53	disease	1	0.9	neutral	0.35	neutral	1	deleterious	0.67	deleterious	-1.66	low_impact	0.31	medium_impact	0.93	medium_impact	0.54	0.8	70.93	16.47	0.72	P	0.70	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7950	7950	T	C	MI.5968	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	365	122	M	T	aTa/aCa	6.75	1	0	probably_damaging	0.99	neutral	0.35	neutral	1.71	neutral	-2.48	deleterious	-5.76	high_impact	3.63	0.14	damaging	0.02	damaging	3.07	22.40	deleterious	0.39	0.5	0.21	neutral	0.88	disease	0.78	disease	0.68	disease	4	0.99	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-2.58	low_impact	0.06	medium_impact	2.3	high_impact	0.40	0.8	70.93	16.47	0.82	P	0.92	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7950	7950	T	A	MI.5969	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	365	122	M	K	aTa/aAa	6.75	1	0	probably_damaging	0.98	neutral	0.27	neutral	1.68	deleterious	-3.44	deleterious	-5.84	high_impact	4.09	0.15	damaging	0.03	damaging	4.09	23.70	deleterious	0.23	0.45	0.22	neutral	0.9	disease	0.83	disease	0.71	disease	4	0.98	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-2.3	low_impact	-0.03	medium_impact	2.73	high_impact	0.36	0.8	70.93	16.47	0.85	P	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8807	8807	C	A	MI.597	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	281	94	P	Q	cCa/cAa	5.45	0.99	0	probably_damaging	1	deleterious	0.01	neutral	3.59	deleterious	-3.78	deleterious	-7.24	medium_impact	3.19	0.7	neutral	0.13	damaging	4.10	23.70	deleterious	0.21	0.65	0.91	disease	0.75	disease	0.74	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-0.84	medium_impact	1.64	medium_impact	0.74	0.9	49.56	8.53	0.43	N	0.82	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7951	7951	A	C	MI.5970	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	366	122	M	I	atA/atC	7.44	1	0	probably_damaging	0.96	neutral	0.42	neutral	1.84	neutral	-0.92	deleterious	-3.68	medium_impact	2.1	0.26	damaging	0.28	damaging	3.46	23.00	deleterious	0.48	0.55	0.26	neutral	0.81	disease	0.71	disease	0.56	disease	1	0.96	neutral	0.23	neutral	1	deleterious	0.77	deleterious	-2.01	low_impact	0.13	medium_impact	0.86	medium_impact	0.54	0.8	70.93	16.47	0.91	P	0.78	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7951	7951	A	T	MI.5971	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	366	122	M	I	atA/atT	7.44	1	0	probably_damaging	0.96	neutral	0.42	neutral	1.84	neutral	-0.92	deleterious	-3.68	medium_impact	2.1	0.26	damaging	0.28	damaging	3.52	23.10	deleterious	0.48	0.55	0.26	neutral	0.81	disease	0.71	disease	0.56	disease	1	0.96	neutral	0.23	neutral	1	deleterious	0.77	deleterious	-2.01	low_impact	0.13	medium_impact	0.86	medium_impact	0.54	0.8	70.93	16.47	0.91	P	0.78	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7952	7952	C	T	MI.5972	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	367	123	L	F	Ctt/Ttt	0.06	0	0	possibly_damaging	0.7	neutral	0.24	neutral	1.84	neutral	-2.13	neutral	-2.03	low_impact	1.9	0.73	neutral	0.59	neutral	3.91	23.50	deleterious	0.37	0.5	0.36	neutral	0.48	neutral	0.66	disease	0.59	disease	2	0.81	neutral	0.27	neutral	-3	neutral	0.61	deleterious	-1.06	low_impact	-0.07	medium_impact	0.68	medium_impact	0.56	0.8	29.96	72.1	0.37	N	0.39	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7952	7952	C	G	MI.5973	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	367	123	L	V	Ctt/Gtt	0.06	0	0	possibly_damaging	0.45	neutral	0.43	neutral	2.01	neutral	0.04	neutral	0.99	neutral_impact	-0.12	0.78	neutral	0.92	neutral	1.33	12.43	neutral	0.39	0.5	0.14	neutral	0.22	neutral	0.34	neutral	0.37	neutral	3	0.53	neutral	0.49	deleterious	-3	neutral	0.33	neutral	-0.64	medium_impact	0.14	medium_impact	-1.22	low_impact	0.50	0.8	29.96	72.1	0.31	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7952	7952	C	A	MI.5974	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	367	123	L	I	Ctt/Att	0.06	0	0	possibly_damaging	0.45	neutral	0.37	neutral	2.04	neutral	0.27	neutral	1.18	neutral_impact	-1.17	0.75	neutral	0.98	neutral	1.13	11.37	neutral	0.37	0.5	0.12	neutral	0.03	neutral	0.24	neutral	0.19	neutral	6	0.59	neutral	0.46	neutral	-3	neutral	0.32	neutral	-0.64	medium_impact	0.08	medium_impact	-2.2	low_impact	0.59	0.8	29.96	72.1	0.43	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7953	7953	T	A	MI.5975	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	368	123	L	H	cTt/cAt	0.29	0	0	probably_damaging	0.97	neutral	0.26	neutral	1.81	deleterious	-3.23	deleterious	-4.29	medium_impact	2.6	0.71	neutral	0.5	neutral	4.30	24.00	deleterious	0.29	0.45	0.53	disease	0.57	disease	0.68	disease	0.71	disease	4	0.97	neutral	0.15	neutral	1	deleterious	0.72	deleterious	-2.13	low_impact	-0.05	medium_impact	1.33	medium_impact	0.57	0.8	29.96	72.1	0.33	N	0.55	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7953	7953	T	C	MI.5976	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	368	123	L	P	cTt/cCt	0.29	0	0	probably_damaging	0.95	neutral	0.34	neutral	1.81	deleterious	-3.31	deleterious	-3.91	medium_impact	2.05	0.8	neutral	0.4	neutral	3.99	23.60	deleterious	0.21	0.45	0.35	neutral	0.81	disease	0.65	disease	0.76	disease	5	0.96	neutral	0.2	neutral	1	deleterious	0.73	deleterious	-1.91	low_impact	0.05	medium_impact	0.82	medium_impact	0.56	0.8	29.96	72.1	0.25	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7953	7953	T	G	MI.5977	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	368	123	L	R	cTt/cGt	0.29	0	0	probably_damaging	0.91	neutral	0.57	neutral	1.83	neutral	-2.38	deleterious	-4.01	low_impact	1.9	0.69	neutral	0.45	neutral	4.26	23.90	deleterious	0.32	0.5	0.25	neutral	0.83	disease	0.71	disease	0.75	disease	5	0.89	neutral	0.33	neutral	-2	neutral	0.70	deleterious	-1.66	low_impact	0.27	medium_impact	0.68	medium_impact	0.65	0.8	29.96	72.1	0.24	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7955	7955	C	G	MI.5978	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	370	124	P	A	Ccc/Gcc	-5.24	0	0	probably_damaging	0.99	neutral	0.49	neutral	1.86	neutral	-0.96	deleterious	-6.86	medium_impact	2.31	0.44	damaging	0.12	damaging	3.16	22.60	deleterious	0.28	0.45	0.46	neutral	0.62	disease	0.59	disease	0.56	disease	1	0.99	deleterious	0.25	neutral	1	deleterious	0.74	deleterious	-2.58	low_impact	0.2	medium_impact	1.06	medium_impact	0.51	0.8	68.72	18.75	0.33	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7955	7955	C	A	MI.5979	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	370	124	P	T	Ccc/Acc	-5.24	0	0	probably_damaging	1	neutral	0.39	neutral	1.82	neutral	-0.76	deleterious	-6.77	medium_impact	2.22	0.36	damaging	0.04	damaging	3.77	23.40	deleterious	0.3	0.45	0.44	neutral	0.75	disease	0.45	neutral	0.52	disease	0	1	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-3.52	low_impact	0.1	medium_impact	0.98	medium_impact	0.37	0.8	68.72	18.75	0.37	N	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8807	8807	C	G	MI.598	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	281	94	P	R	cCa/cGa	5.45	0.99	0	probably_damaging	1	deleterious	0.01	neutral	3.6	deleterious	-3.79	deleterious	-8.15	high_impact	4.09	0.69	neutral	0.13	damaging	3.48	23.10	deleterious	0.23	0.65	0.91	disease	0.78	disease	0.79	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	2.41	high_impact	0.74	0.9	49.56	8.53	0.51	P	0.65	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7955	7955	C	T	MI.5980	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	370	124	P	S	Ccc/Tcc	-5.24	0	0	probably_damaging	1	neutral	0.4	neutral	1.87	neutral	-1.03	deleterious	-6.69	low_impact	1.82	0.38	damaging	0.06	damaging	3.96	23.60	deleterious	0.32	0.5	0.25	neutral	0.71	disease	0.31	neutral	0.39	neutral	2	1	deleterious	0.2	neutral	-2	neutral	0.73	deleterious	-3.52	low_impact	0.11	medium_impact	0.6	medium_impact	0.20	0.8	68.72	18.75	0.36	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7956	7956	C	G	MI.5981	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	371	124	P	R	cCc/cGc	4.44	0.99	0	probably_damaging	1	neutral	0.33	neutral	1.81	neutral	-1.35	deleterious	-7.55	medium_impact	3.3	0.24	damaging	0.03	damaging	3.72	23.30	deleterious	0.29	0.45	0.68	disease	0.89	disease	0.67	disease	0.72	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	0.04	medium_impact	1.99	medium_impact	0.38	0.8	68.72	18.75	0.79	P	0.85	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7956	7956	C	A	MI.5982	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	371	124	P	H	cCc/cAc	4.44	0.99	0	probably_damaging	1	neutral	0.52	neutral	1.78	neutral	-2.63	deleterious	-7.58	medium_impact	3.15	0.4	damaging	0.05	damaging	4.09	23.70	deleterious	0.29	0.45	0.79	disease	0.84	disease	0.55	disease	0.69	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	0.22	medium_impact	1.85	medium_impact	0.40	0.8	68.72	18.75	0.57	P	0.79	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7956	7956	C	T	MI.5983	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	371	124	P	L	cCc/cTc	4.44	0.99	0	probably_damaging	1	neutral	0.64	neutral	1.8	neutral	-2.45	deleterious	-8.62	medium_impact	2.25	0.36	damaging	0.03	damaging	4.47	24.20	deleterious	0.35	0.5	0.72	disease	0.86	disease	0.55	disease	0.68	disease	4	1	deleterious	0.32	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	0.34	medium_impact	1	medium_impact	0.70	0.85	68.72	18.75	0.58	P	0.92	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7958	7958	C	T	MI.5984	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	373	125	P	S	Cca/Tca	-8.47	0	0	benign	0.07	neutral	0.76	neutral	2.09	neutral	-0.7	neutral	1.63	neutral_impact	-1.34	0.82	neutral	0.82	neutral	0.99	10.60	neutral	0.61	0.65	0.23	neutral	0.13	neutral	0.15	neutral	0.3	neutral	4	0.15	neutral	0.85	deleterious	-6	neutral	0.12	neutral	0.33	medium_impact	0.48	medium_impact	-2.36	low_impact	0.31	0.8	27.31	73.7	0.34	N	0.41	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7958	7958	C	G	MI.5985	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	373	125	P	A	Cca/Gca	-8.47	0	0	benign	0.33	neutral	0.68	neutral	2.07	neutral	-0.75	neutral	0.75	neutral_impact	-0.06	0.77	neutral	0.86	neutral	1.46	13.09	neutral	0.43	0.55	0.26	neutral	0.14	neutral	0.31	neutral	0.3	neutral	4	0.26	neutral	0.68	deleterious	-6	neutral	0.34	neutral	-0.43	medium_impact	0.39	medium_impact	-1.16	low_impact	0.82	0.85	27.31	73.7	0.31	N	0.32	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7958	7958	C	A	MI.5986	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	373	125	P	T	Cca/Aca	-8.47	0	0	possibly_damaging	0.57	neutral	0.75	neutral	2.09	neutral	-0.68	neutral	4.93	neutral_impact	-2.15	0.75	neutral	0.94	neutral	0.73	9.02	deleterious	0.53	0.6	0.14	neutral	0.05	neutral	0.1	neutral	0.2	neutral	6	0.48	neutral	0.59	deleterious	-3	neutral	0.41	neutral	-0.84	medium_impact	0.47	medium_impact	-3.12	low_impact	0.73	0.85	27.31	73.7	0.34	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7959	7959	C	G	MI.5987	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	374	125	P	R	cCa/cGa	4.44	0.99	0	possibly_damaging	0.88	neutral	0.47	neutral	2.05	neutral	-0.88	neutral	-0.34	neutral_impact	-0.59	0.66	neutral	0.47	neutral	3.54	23.10	deleterious	0.41	0.5	0.3	neutral	0.51	disease	0.55	disease	0.64	disease	3	0.87	neutral	0.3	neutral	-3	neutral	0.62	deleterious	-1.53	low_impact	0.18	medium_impact	-1.66	low_impact	0.68	0.85	27.31	73.7	0.41	N	0.70	polymorphism	0.94	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7959	7959	C	T	MI.5988	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	374	125	P	L	cCa/cTa	4.44	0.99	0	possibly_damaging	0.76	neutral	0.31	neutral	2.04	neutral	-2.16	neutral	-0.14	neutral_impact	-1.23	0.72	neutral	0.6	neutral	4.24	23.90	deleterious	0.5	0.6	0.31	neutral	0.31	neutral	0.32	neutral	0.45	neutral	1	0.81	neutral	0.28	neutral	-3	neutral	0.54	deleterious	-1.19	low_impact	0.01	medium_impact	-2.26	low_impact	0.74	0.85	27.31	73.7	0.59	P	0.74	disease_causing	0.94	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7959	7959	C	A	MI.5989	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	374	125	P	Q	cCa/cAa	4.44	0.99	0	possibly_damaging	0.88	neutral	0.59	neutral	2.06	neutral	-0.78	neutral	-0.24	neutral_impact	-0.76	0.75	neutral	0.53	neutral	4.05	23.70	deleterious	0.4	0.5	0.27	neutral	0.13	neutral	0.21	neutral	0.3	neutral	4	0.86	neutral	0.36	neutral	-3	neutral	0.59	deleterious	-1.53	low_impact	0.29	medium_impact	-1.82	low_impact	0.64	0.8	27.31	73.7	0.48	N	0.66	polymorphism	0.97	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8807	8807	C	T	MI.599	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	281	94	P	L	cCa/cTa	5.45	0.99	0	probably_damaging	1	neutral	0.19	neutral	3.69	neutral	-1.73	deleterious	-9.06	medium_impact	2.4	0.66	neutral	0.14	damaging	4.28	24.00	deleterious	0.35	0.65	0.7	disease	0.71	disease	0.7	disease	0.67	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.06	medium_impact	0.96	medium_impact	0.75	0.9	49.56	8.53	0.45	N	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7961	7961	T	G	MI.5990	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	376	126	L	V	Tta/Gta	-4.55	0	0.01	probably_damaging	0.99	neutral	0.25	neutral	1.99	neutral	-0.54	neutral	0.02	low_impact	0.82	0.71	neutral	0.7	neutral	2.43	18.99	deleterious	0.63	0.65	0.36	neutral	0.32	neutral	0.34	neutral	0.45	neutral	1	1	deleterious	0.13	neutral	-2	neutral	0.66	deleterious	-2.58	low_impact	-0.06	medium_impact	-0.34	medium_impact	0.71	0.85	33.48	60.65	0.44	N	0.18	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7961	7961	T	A	MI.5991	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	376	126	L	M	Tta/Ata	-4.55	0	0.01	probably_damaging	1	neutral	0.14	neutral	1.98	neutral	-1.52	neutral	1.11	neutral_impact	0.7	0.75	neutral	0.71	neutral	2.61	20.30	deleterious	0.48	0.55	0.5	disease	0.23	neutral	0.23	neutral	0.18	neutral	6	1	deleterious	0.07	neutral	-2	neutral	0.67	deleterious	-3.52	low_impact	-0.23	medium_impact	-0.45	medium_impact	0.70	0.85	33.48	60.65	0.47	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7962	7962	T	C	MI.5992	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	377	126	L	S	tTa/tCa	-2.01	0	0	probably_damaging	1	neutral	0.78	neutral	2.16	neutral	2.97	neutral	2.04	neutral_impact	-0.63	0.81	neutral	0.96	neutral	2.22	17.66	deleterious	0.52	0.6	0.16	neutral	0.24	neutral	0.17	neutral	0.42	neutral	2	1	deleterious	0.39	neutral	-2	neutral	0.64	deleterious	-3.52	low_impact	0.51	medium_impact	-1.7	low_impact	0.73	0.85	33.48	60.65	0.37	N	0.06	polymorphism	1	0.00	.	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7962	7962	T	G	MI.5993	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	377	126	L	W	tTa/tGa	-2.01	0	0	probably_damaging	1	neutral	0.05	neutral	1.98	neutral	-1.86	neutral	-0.65	low_impact	1.79	0.66	neutral	0.49	neutral	3.84	23.40	deleterious	0.35	0.5	0.78	disease	0.55	disease	0.41	neutral	0.51	disease	0	1	deleterious	0.03	neutral	-2	neutral	0.76	deleterious	-3.52	low_impact	-0.5	medium_impact	0.57	medium_impact	0.68	0.85	33.48	60.65	0.41	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7963	7963	A	C	MI.5994	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	378	126	L	F	ttA/ttC	-0.17	0	0	probably_damaging	1	neutral	0.05	neutral	1.99	neutral	-0.82	neutral	-0.72	low_impact	1.25	0.68	neutral	0.64	neutral	3.60	23.20	deleterious	0.58	0.65	0.56	disease	0.38	neutral	0.36	neutral	0.62	disease	2	1	deleterious	0.03	neutral	-2	neutral	0.71	deleterious	-3.52	low_impact	-0.5	medium_impact	0.07	medium_impact	0.54	0.8	33.48	60.65	0.46	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7963	7963	A	T	MI.5995	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	378	126	L	F	ttA/ttT	-0.17	0	0	probably_damaging	1	neutral	0.05	neutral	1.99	neutral	-0.82	neutral	-0.72	low_impact	1.25	0.68	neutral	0.64	neutral	3.64	23.20	deleterious	0.58	0.65	0.56	disease	0.38	neutral	0.36	neutral	0.62	disease	2	1	deleterious	0.03	neutral	-2	neutral	0.71	deleterious	-3.52	low_impact	-0.5	medium_impact	0.07	medium_impact	0.54	0.8	33.48	60.65	0.46	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7964	7964	T	C	MI.5996	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	379	127	F	L	Ttc/Ctc	-0.4	0	0.01	probably_damaging	0.99	neutral	0.7	neutral	2.05	neutral	1.46	neutral	-1.1	neutral_impact	-0.02	0.76	neutral	0.49	neutral	4.09	23.70	deleterious	0.49	0.55	0.17	neutral	0.42	neutral	0.52	disease	0.47	neutral	1	0.99	deleterious	0.36	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.41	medium_impact	-1.12	low_impact	0.31	0.8	28.19	61.06	0.28	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7964	7964	T	G	MI.5997	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	379	127	F	V	Ttc/Gtc	-0.4	0	0.01	probably_damaging	0.99	neutral	0.43	neutral	2.02	neutral	0.92	neutral	-0.31	low_impact	1.3	0.7	neutral	0.61	neutral	4.13	23.80	deleterious	0.45	0.55	0.23	neutral	0.54	disease	0.55	disease	0.61	disease	2	0.99	deleterious	0.22	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.14	medium_impact	0.11	medium_impact	0.42	0.8	28.19	61.06	0.34	N	0.50	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7964	7964	T	A	MI.5998	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	379	127	F	I	Ttc/Atc	-0.4	0	0.01	probably_damaging	0.99	neutral	0.3	neutral	2.01	neutral	0.34	neutral	-0.42	low_impact	1.3	0.69	neutral	0.58	neutral	4.43	24.20	deleterious	0.46	0.55	0.16	neutral	0.43	neutral	0.54	disease	0.48	neutral	0	0.99	deleterious	0.16	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0	medium_impact	0.11	medium_impact	0.33	0.8	28.19	61.06	0.4	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7965	7965	T	G	MI.5999	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	380	127	F	C	tTc/tGc	5.13	1	0	probably_damaging	1	neutral	0.1	neutral	1.98	neutral	-1.48	neutral	-0.73	low_impact	1.3	0.66	neutral	0.45	neutral	4.20	23.90	deleterious	0.33	0.5	0.56	disease	0.61	disease	0.57	disease	0.67	disease	3	1	deleterious	0.05	neutral	-2	neutral	0.71	deleterious	-3.52	low_impact	-0.32	medium_impact	0.11	medium_impact	0.27	0.8	28.19	61.06	0.51	P	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8529	8529	G	C	MI.6	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	3	1	M	I	atG/atC	7.53	1	0	possibly_damaging	0.72	deleterious	0	neutral	4.58	neutral	0.17	deleterious	-3.33	NA	NA	0.68	neutral	0.12	damaging	4.06	23.70	deleterious	0.46	0.65	0.77	disease	0.44	neutral	0.64	disease	0.61	disease	2	1	deleterious	0.14	neutral	3	deleterious	0.68	deleterious	NA	NA	NA	NA	NA	NA	0.55	0.9	50	8.74	0.6	P	0.94	NA	NA	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8553	8553	C	G	MI.60	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	27	9	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.92	neutral	0.06	neutral	3.94	neutral	-0.84	deleterious	-5.27	medium_impact	2.34	0.57	damaging	0.59	neutral	4.64	24.50	deleterious	0.4	0.65	0.6	disease	0.77	disease	0.82	disease	0.8	disease	6	0.98	deleterious	0.07	neutral	1	deleterious	0.76	deleterious	-1.76	low_impact	-0.38	medium_impact	0.91	medium_impact	0.44	0.9	49.56	8.77	0.59	P	0.89	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8809	8809	A	C	MI.600	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	283	95	T	P	Acc/Ccc	-13.29	0	0	probably_damaging	1	deleterious	0.01	neutral	3.28	deleterious	-4.81	deleterious	-5.53	high_impact	3.84	0.53	damaging	0.13	damaging	4.00	23.60	deleterious	0.21	0.65	0.96	disease	0.68	disease	0.77	disease	0.78	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	2.19	high_impact	0.50	0.9	50.44	8.81	0.31	N	0.99	disease_causing	0.98	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7965	7965	T	C	MI.6000	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	380	127	F	S	tTc/tCc	5.13	1	0	probably_damaging	1	neutral	0.95	neutral	2.08	neutral	2.11	neutral	2.26	neutral_impact	-0.61	0.68	neutral	0.71	neutral	4.39	24.10	deleterious	0.36	0.5	0.15	neutral	0.43	neutral	0.36	neutral	0.44	neutral	1	1	deleterious	0.48	deleterious	-2	neutral	0.65	deleterious	-3.52	low_impact	0.91	medium_impact	-1.68	low_impact	0.30	0.8	28.19	61.06	0.47	N	0.38	polymorphism	1	0.00	.	Uncertain_significance	Hepatic_failure,_early-onset,_and_neurologic_disorder_due_to_cytochrome_C_oxidase_deficiency	434458	MedGen:C0268237,OMIM:220110,Orphanet:ORPHA254905,SNOMED_CT:67434000	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7965	7965	T	A	MI.6001	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	380	127	F	Y	tTc/tAc	5.13	1	0	probably_damaging	0.99	neutral	0.51	neutral	2	neutral	-0.13	neutral	0.04	neutral_impact	0.02	0.73	neutral	0.75	neutral	4.53	24.30	deleterious	0.46	0.55	0.37	neutral	0.32	neutral	0.55	disease	0.47	neutral	1	0.99	deleterious	0.26	neutral	-2	neutral	0.67	deleterious	-2.58	low_impact	0.21	medium_impact	-1.09	low_impact	0.38	0.8	28.19	61.06	0.56	P	0.31	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7966	7966	C	G	MI.6002	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	381	127	F	L	ttC/ttG	4.67	1	0	probably_damaging	0.99	neutral	0.7	neutral	2.05	neutral	1.46	neutral	-1.1	neutral_impact	-0.02	0.76	neutral	0.49	neutral	4.49	24.30	deleterious	0.49	0.55	0.17	neutral	0.42	neutral	0.52	disease	0.47	neutral	1	0.99	deleterious	0.36	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.41	medium_impact	-1.12	low_impact	0.31	0.8	28.19	61.06	0.44	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7966	7966	C	A	MI.6003	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	381	127	F	L	ttC/ttA	4.67	1	0	probably_damaging	0.99	neutral	0.7	neutral	2.05	neutral	1.46	neutral	-1.1	neutral_impact	-0.02	0.76	neutral	0.49	neutral	4.81	24.80	deleterious	0.49	0.55	0.17	neutral	0.42	neutral	0.52	disease	0.47	neutral	1	0.99	deleterious	0.36	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.41	medium_impact	-1.12	low_impact	0.31	0.8	28.19	61.06	0.44	N	0.51	polymorphism	1	0.01	rs879093898	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	7967	7967	C	G	MI.6004	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	382	128	L	V	Cta/Gta	-4.32	0	0	probably_damaging	0.99	neutral	0.3	neutral	1.49	neutral	-2.37	deleterious	-2.96	medium_impact	2.81	0.34	damaging	0.33	neutral	3.50	23.10	deleterious	0.52	0.6	0.37	neutral	0.51	disease	0.62	disease	0.62	disease	2	0.99	deleterious	0.16	neutral	1	deleterious	0.71	deleterious	-2.58	low_impact	0	medium_impact	1.53	medium_impact	0.37	0.8	68.72	19.83	0.54	P	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7967	7967	C	A	MI.6005	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	382	128	L	M	Cta/Ata	-4.32	0	0	probably_damaging	1	neutral	0.13	neutral	1.42	deleterious	-3.23	neutral	-1.97	low_impact	1.9	0.48	damaging	0.48	neutral	3.78	23.40	deleterious	0.28	0.45	0.59	disease	0.15	neutral	0.29	neutral	0.34	neutral	3	1	deleterious	0.07	neutral	-2	neutral	0.71	deleterious	-3.52	low_impact	-0.25	medium_impact	0.68	medium_impact	0.65	0.8	68.72	19.83	0.49	P	0.78	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7968	7968	T	G	MI.6006	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	383	128	L	R	cTa/cGa	-1.32	0	0	probably_damaging	1	neutral	0.54	neutral	1.37	deleterious	-4.66	deleterious	-5.92	medium_impact	3.26	0.28	damaging	0.26	damaging	4.27	24.00	deleterious	0.28	0.45	0.66	disease	0.85	disease	0.71	disease	0.76	disease	5	1	deleterious	0.27	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.24	medium_impact	1.95	medium_impact	0.50	0.8	68.72	19.83	0.8	P	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7968	7968	T	A	MI.6007	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	383	128	L	Q	cTa/cAa	-1.32	0	0	probably_damaging	1	neutral	0.58	neutral	1.36	deleterious	-4.75	deleterious	-5.92	medium_impact	3	0.44	damaging	0.34	neutral	4.16	23.80	deleterious	0.28	0.45	0.67	disease	0.7	disease	0.56	disease	0.6	disease	2	1	deleterious	0.29	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.28	medium_impact	1.71	medium_impact	0.53	0.8	68.72	19.83	0.4	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7968	7968	T	C	MI.6008	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	383	128	L	P	cTa/cCa	-1.32	0	0	probably_damaging	1	neutral	0.3	neutral	1.36	deleterious	-4.77	deleterious	-6.9	medium_impact	2.96	0.28	damaging	0.32	neutral	4.01	23.60	deleterious	0.24	0.45	0.32	neutral	0.81	disease	0.64	disease	0.69	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	0	medium_impact	1.67	medium_impact	0.36	0.8	68.72	19.83	0.75	P	0.99	polymorphism	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7970	7970	G	C	MI.6009	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	385	129	E	Q	Gaa/Caa	-1.78	0	0	benign	0.14	neutral	0.6	neutral	1.86	neutral	-1.42	neutral	-0.31	neutral_impact	0.6	0.8	neutral	0.78	neutral	-0.35	0.52	neutral	0.59	0.65	0.24	neutral	0.16	neutral	0.24	neutral	0.29	neutral	4	0.29	neutral	0.73	deleterious	-6	neutral	0.16	neutral	0.01	medium_impact	0.3	medium_impact	-0.54	medium_impact	0.57	0.8	34.8	62.05	0.33	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8809	8809	A	T	MI.601	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	283	95	T	S	Acc/Tcc	-13.29	0	0	probably_damaging	0.99	neutral	0.22	neutral	3.47	neutral	-1.81	deleterious	-3.64	medium_impact	2.25	0.68	neutral	0.17	damaging	3.86	23.40	deleterious	0.31	0.65	0.75	disease	0.28	neutral	0.57	disease	0.53	disease	1	0.99	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	-0.02	medium_impact	0.83	medium_impact	0.74	0.9	50.44	8.81	0.31	N	0.88	disease_causing	0.8	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7970	7970	G	A	MI.6010	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	385	129	E	K	Gaa/Aaa	-1.78	0	0	benign	0	neutral	0.93	neutral	1.92	neutral	-1.01	neutral	-0.25	neutral_impact	-0.12	0.78	neutral	0.93	neutral	0.10	3.61	deleterious	0.43	0.55	0.25	neutral	0.27	neutral	0.25	neutral	0.44	neutral	1	0.05	neutral	0.97	deleterious	-6	neutral	0.13	neutral	2.08	high_impact	0.83	medium_impact	-1.22	low_impact	0.74	0.85	34.8	62.05	0.3	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7971	7971	A	G	MI.6011	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	386	129	E	G	gAa/gGa	0.06	0	0	benign	0.14	neutral	0.39	neutral	1.81	neutral	-2.59	neutral	-1.95	low_impact	1.31	0.76	neutral	0.64	neutral	0.96	10.41	neutral	0.49	0.55	0.53	disease	0.24	neutral	0.42	neutral	0.34	neutral	3	0.54	neutral	0.63	deleterious	-6	neutral	0.20	neutral	0.01	medium_impact	0.1	medium_impact	0.12	medium_impact	0.52	0.8	34.8	62.05	0.4	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7971	7971	A	T	MI.6012	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	386	129	E	V	gAa/gTa	0.06	0	0	benign	0.34	neutral	0.32	neutral	1.81	neutral	-2.86	neutral	-1.03	low_impact	1.55	0.77	neutral	0.7	neutral	1.10	11.20	neutral	0.42	0.55	0.38	neutral	0.41	neutral	0.39	neutral	0.46	neutral	1	0.62	neutral	0.49	deleterious	-6	neutral	0.31	neutral	-0.45	medium_impact	0.02	medium_impact	0.35	medium_impact	0.65	0.8	34.8	62.05	0.41	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7971	7971	A	C	MI.6013	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	386	129	E	A	gAa/gCa	0.06	0	0	benign	0.14	neutral	0.77	neutral	1.89	neutral	-1.17	neutral	-0.2	neutral_impact	0.38	0.78	neutral	0.85	neutral	-0.37	0.46	neutral	0.45	0.55	0.35	neutral	0.23	neutral	0.36	neutral	0.43	neutral	1	0.12	neutral	0.82	deleterious	-6	neutral	0.19	neutral	0.01	medium_impact	0.5	medium_impact	-0.75	medium_impact	0.55	0.8	34.8	62.05	0.27	N	0.22	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7972	7972	A	C	MI.6014	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	387	129	E	D	gaA/gaC	0.29	0	0	benign	0.09	neutral	0.63	neutral	1.86	neutral	-0.39	neutral	-0.96	neutral_impact	0.44	0.77	neutral	0.75	neutral	0.15	4.09	deleterious	0.6	0.65	0.41	neutral	0.22	neutral	0.19	neutral	0.41	neutral	2	0.27	neutral	0.77	deleterious	-6	neutral	0.16	neutral	0.22	medium_impact	0.33	medium_impact	-0.69	medium_impact	0.78	0.85	34.8	62.05	0.38	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7972	7972	A	T	MI.6015	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	387	129	E	D	gaA/gaT	0.29	0	0	benign	0.09	neutral	0.63	neutral	1.86	neutral	-0.39	neutral	-0.96	neutral_impact	0.44	0.77	neutral	0.75	neutral	0.24	5.14	deleterious	0.6	0.65	0.41	neutral	0.22	neutral	0.19	neutral	0.41	neutral	2	0.27	neutral	0.77	deleterious	-6	neutral	0.16	neutral	0.22	medium_impact	0.33	medium_impact	-0.69	medium_impact	0.78	0.85	34.8	62.05	0.38	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7973	7973	C	T	MI.6016	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	388	130	P	S	Cca/Tca	-6.86	0	0	probably_damaging	1	neutral	0.77	neutral	2.04	neutral	-0.7	deleterious	-4.45	low_impact	1.16	0.62	neutral	0.49	neutral	2.71	20.80	deleterious	0.57	0.65	0.27	neutral	0.18	neutral	0.18	neutral	0.3	neutral	4	1	deleterious	0.39	neutral	-2	neutral	0.65	deleterious	-3.52	low_impact	0.5	medium_impact	-0.02	medium_impact	0.30	0.8	67.84	18.83	0.33	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7973	7973	C	G	MI.6017	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	388	130	P	A	Cca/Gca	-6.86	0	0	probably_damaging	0.99	neutral	0.81	neutral	2.03	neutral	-0.42	deleterious	-4.93	low_impact	1.64	0.59	damaging	0.33	neutral	2.04	16.47	deleterious	0.48	0.55	0.25	neutral	0.2	neutral	0.33	neutral	0.37	neutral	3	0.99	deleterious	0.41	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.55	medium_impact	0.43	medium_impact	0.74	0.85	67.84	18.83	0.24	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7973	7973	C	A	MI.6018	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	388	130	P	T	Cca/Aca	-6.86	0	0	probably_damaging	1	neutral	0.62	neutral	2.02	neutral	-1.22	deleterious	-4.83	low_impact	1.34	0.57	damaging	0.2	damaging	2.81	21.40	deleterious	0.49	0.55	0.16	neutral	0.17	neutral	0.32	neutral	0.28	neutral	4	1	deleterious	0.31	neutral	-2	neutral	0.63	deleterious	-3.52	low_impact	0.32	medium_impact	0.15	medium_impact	0.68	0.85	67.84	18.83	0.23	N	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7974	7974	C	T	MI.6019	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	389	130	P	L	cCa/cTa	0.98	0	0	probably_damaging	1	neutral	0.42	neutral	2.02	neutral	-1.21	deleterious	-6.66	low_impact	0.94	0.58	damaging	0.53	neutral	3.17	22.70	deleterious	0.49	0.55	0.16	neutral	0.32	neutral	0.35	neutral	0.43	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.65	deleterious	-3.52	low_impact	0.13	medium_impact	-0.22	medium_impact	0.88	0.9	67.84	18.83	0.35	N	0.92	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8809	8809	A	G	MI.602	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	283	95	T	A	Acc/Gcc	-13.29	0	0	probably_damaging	0.99	neutral	0.06	neutral	3.31	deleterious	-3.67	deleterious	-4.55	high_impact	3.73	0.69	neutral	0.15	damaging	4.01	23.60	deleterious	0.38	0.65	0.85	disease	0.4	neutral	0.77	disease	0.68	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.79	deleterious	-2.65	low_impact	-0.38	medium_impact	2.1	high_impact	0.62	0.9	50.44	8.81	0.38	N	0.63	disease_causing	0.92	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7974	7974	C	G	MI.6020	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	389	130	P	R	cCa/cGa	0.98	0	0	probably_damaging	1	neutral	0.56	neutral	2.01	neutral	-1.25	deleterious	-5.59	low_impact	1.84	0.44	damaging	0.11	damaging	3.63	23.20	deleterious	0.49	0.55	0.33	neutral	0.51	disease	0.45	neutral	0.49	neutral	0	1	deleterious	0.28	neutral	-2	neutral	0.70	deleterious	-3.52	low_impact	0.26	medium_impact	0.62	medium_impact	0.68	0.85	67.84	18.83	0.33	N	0.85	polymorphism	0.77	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7974	7974	C	A	MI.6021	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	389	130	P	Q	cCa/cAa	0.98	0	0	probably_damaging	1	neutral	0.62	neutral	2.02	neutral	-1.18	deleterious	-4.85	low_impact	1.76	0.65	neutral	0.41	neutral	3.11	22.50	deleterious	0.47	0.55	0.31	neutral	0.25	neutral	0.28	neutral	0.44	neutral	1	1	deleterious	0.31	neutral	-2	neutral	0.67	deleterious	-3.52	low_impact	0.32	medium_impact	0.55	medium_impact	0.49	0.8	67.84	18.83	0.29	N	0.88	polymorphism	0.86	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7976	7976	G	A	MI.6022	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	391	131	G	S	Ggc/Agc	-5.24	0	0	probably_damaging	1	neutral	0.93	neutral	1.88	neutral	-1.36	deleterious	-5.88	medium_impact	2.06	0.57	damaging	0.22	damaging	4.23	23.90	deleterious	0.64	0.7	0.39	neutral	0.47	neutral	0.33	neutral	0.39	neutral	2	1	deleterious	0.47	neutral	1	deleterious	0.71	deleterious	-3.52	low_impact	0.83	medium_impact	0.83	medium_impact	0.88	0.9	67.84	19.7	0.23	N	0.98	disease_causing	0.88	0.05	rs377368526	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	7976	7976	G	T	MI.6023	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	391	131	G	C	Ggc/Tgc	-5.24	0	0	probably_damaging	1	neutral	0.2	neutral	1.76	deleterious	-5.67	deleterious	-8.81	high_impact	4.08	0.46	damaging	0.18	damaging	4.27	23.90	deleterious	0.24	0.45	0.77	disease	0.79	disease	0.59	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	-0.13	medium_impact	2.72	high_impact	0.41	0.8	67.84	19.7	0.34	N	0.99	disease_causing	0.97	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7976	7976	G	C	MI.6024	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	391	131	G	R	Ggc/Cgc	-5.24	0	0	probably_damaging	1	neutral	0.7	neutral	1.84	neutral	-2.21	deleterious	-7.84	medium_impact	3.11	0.39	damaging	0.16	damaging	4.08	23.70	deleterious	0.38	0.5	0.47	neutral	0.83	disease	0.68	disease	0.72	disease	4	1	deleterious	0.35	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.41	medium_impact	1.81	medium_impact	0.86	0.9	67.84	19.7	0.41	N	1.00	disease_causing	0.94	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7977	7977	G	T	MI.6025	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	392	131	G	V	gGc/gTc	9.05	1	0	probably_damaging	1	neutral	0.67	neutral	1.78	deleterious	-3.02	deleterious	-8.82	medium_impact	3.19	0.46	damaging	0.2	damaging	3.86	23.50	deleterious	0.39	0.5	0.43	neutral	0.72	disease	0.58	disease	0.67	disease	3	1	deleterious	0.34	neutral	1	deleterious	0.76	deleterious	-3.52	low_impact	0.38	medium_impact	1.89	medium_impact	0.44	0.8	67.84	19.7	0.47	N	1.00	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7977	7977	G	A	MI.6026	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	392	131	G	D	gGc/gAc	9.05	1	0	probably_damaging	1	neutral	0.65	neutral	1.89	neutral	-1.89	deleterious	-6.87	medium_impact	2.21	0.53	damaging	0.17	damaging	3.91	23.50	deleterious	0.42	0.5	0.42	neutral	0.67	disease	0.49	neutral	0.23	neutral	5	1	deleterious	0.33	neutral	1	deleterious	0.74	deleterious	-3.52	low_impact	0.35	medium_impact	0.97	medium_impact	0.41	0.8	67.84	19.7	0.37	N	0.99	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7977	7977	G	C	MI.6027	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	392	131	G	A	gGc/gCc	9.05	1	0	probably_damaging	1	neutral	0.99	neutral	1.83	neutral	-1.53	deleterious	-5.88	medium_impact	3.04	0.58	damaging	0.34	neutral	3.22	22.80	deleterious	0.62	0.65	0.37	neutral	0.57	disease	0.56	disease	0.64	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.72	deleterious	-3.52	low_impact	1.31	medium_impact	1.75	medium_impact	0.66	0.8	67.84	19.7	0.44	N	0.85	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7979	7979	G	T	MI.6028	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	394	132	D	Y	Gac/Tac	-11.24	0	0	probably_damaging	1	neutral	0.17	neutral	1.93	deleterious	-3.92	neutral	-0.3	low_impact	0.96	0.76	neutral	0.74	neutral	2.97	22.10	deleterious	0.33	0.5	0.66	disease	0.42	neutral	0.5	neutral	0.6	disease	2	1	deleterious	0.09	neutral	-2	neutral	0.72	deleterious	-3.52	low_impact	-0.18	medium_impact	-0.21	medium_impact	0.19	0.8	30.84	49.86	0.42	N	0.82	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7979	7979	G	C	MI.6029	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	394	132	D	H	Gac/Cac	-11.24	0	0	probably_damaging	1	neutral	0.18	neutral	1.95	neutral	-2.82	neutral	1.29	low_impact	0.87	0.76	neutral	0.85	neutral	2.05	16.53	deleterious	0.41	0.5	0.47	neutral	0.3	neutral	0.34	neutral	0.42	neutral	2	1	deleterious	0.09	neutral	-2	neutral	0.67	deleterious	-3.52	low_impact	-0.16	medium_impact	-0.29	medium_impact	0.38	0.8	30.84	49.86	0.43	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8810	8810	C	T	MI.603	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	284	95	T	I	aCc/aTc	6.84	1	0	probably_damaging	1	deleterious	0.01	neutral	3.29	deleterious	-4.35	deleterious	-5.5	high_impact	3.98	0.66	neutral	0.14	damaging	3.89	23.50	deleterious	0.31	0.65	0.97	disease	0.71	disease	0.79	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-0.84	medium_impact	2.31	high_impact	0.74	0.9	50.44	8.81	0.52	P	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7979	7979	G	A	MI.6030	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	394	132	D	N	Gac/Aac	-11.24	0	0	probably_damaging	1	neutral	0.5	neutral	2.01	neutral	-1.63	neutral	-0.04	neutral_impact	0.42	0.74	neutral	0.85	neutral	3.11	22.50	deleterious	0.68	0.7	0.32	neutral	0.13	neutral	0.2	neutral	0.27	neutral	5	1	deleterious	0.25	neutral	-2	neutral	0.64	deleterious	-3.52	low_impact	0.21	medium_impact	-0.71	medium_impact	0.57	0.8	30.84	49.86	0.42	N	0.39	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7980	7980	A	G	MI.6031	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	395	132	D	G	gAc/gGc	0.52	0	0	probably_damaging	1	neutral	0.42	neutral	1.98	neutral	-2.45	neutral	-1.72	neutral_impact	0.12	0.77	neutral	0.79	neutral	3.32	22.90	deleterious	0.35	0.5	0.43	neutral	0.19	neutral	0.32	neutral	0.36	neutral	3	1	deleterious	0.21	neutral	-2	neutral	0.66	deleterious	-3.52	low_impact	0.13	medium_impact	-0.99	medium_impact	0.38	0.8	30.84	49.86	0.33	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7980	7980	A	T	MI.6032	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	395	132	D	V	gAc/gTc	0.52	0	0	probably_damaging	1	neutral	0.34	neutral	1.95	neutral	-2.85	neutral	-2.05	low_impact	1.66	0.71	neutral	0.63	neutral	4.39	24.10	deleterious	0.34	0.5	0.52	disease	0.41	neutral	0.43	neutral	0.33	neutral	3	1	deleterious	0.17	neutral	-2	neutral	0.69	deleterious	-3.52	low_impact	0.05	medium_impact	0.45	medium_impact	0.24	0.8	30.84	49.86	0.39	N	0.77	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7980	7980	A	C	MI.6033	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	395	132	D	A	gAc/gCc	0.52	0	0	probably_damaging	1	neutral	0.75	neutral	2.02	neutral	-1.49	neutral	-1.28	low_impact	1.11	0.79	neutral	0.69	neutral	3.14	22.60	deleterious	0.35	0.5	0.21	neutral	0.35	neutral	0.41	neutral	0.42	neutral	2	1	deleterious	0.38	neutral	-2	neutral	0.65	deleterious	-3.52	low_impact	0.47	medium_impact	-0.07	medium_impact	0.32	0.8	30.84	49.86	0.24	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7981	7981	C	G	MI.6034	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	396	132	D	E	gaC/gaG	2.14	0	0	probably_damaging	1	neutral	1	neutral	2.1	neutral	-0.56	neutral	1.34	neutral_impact	-0.46	0.76	neutral	0.95	neutral	2.16	17.25	deleterious	0.56	0.6	0.2	neutral	0.19	neutral	0.18	neutral	0.37	neutral	3	1	deleterious	0.5	deleterious	-2	neutral	0.62	deleterious	-3.52	low_impact	1.86	high_impact	-1.54	low_impact	0.41	0.8	30.84	49.86	0.3	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7981	7981	C	A	MI.6035	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	396	132	D	E	gaC/gaA	2.14	0	0	probably_damaging	1	neutral	1	neutral	2.1	neutral	-0.56	neutral	1.34	neutral_impact	-0.46	0.76	neutral	0.95	neutral	2.51	19.50	deleterious	0.56	0.6	0.2	neutral	0.19	neutral	0.18	neutral	0.37	neutral	3	1	deleterious	0.5	deleterious	-2	neutral	0.62	deleterious	-3.52	low_impact	1.86	high_impact	-1.54	low_impact	0.41	0.8	30.84	49.86	0.3	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7982	7982	C	A	MI.6036	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	397	133	L	M	Ctg/Atg	-2.01	0	0	probably_damaging	1	neutral	0.23	neutral	1.87	neutral	-2.04	neutral	-0.28	low_impact	1.48	0.74	neutral	0.56	neutral	3.92	23.50	deleterious	0.38	0.5	0.65	disease	0.45	neutral	0.37	neutral	0.59	disease	2	1	deleterious	0.12	neutral	-2	neutral	0.77	deleterious	-3.52	low_impact	-0.09	medium_impact	0.28	medium_impact	0.77	0.85	68.28	16.14	0.43	N	0.78	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7982	7982	C	G	MI.6037	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	397	133	L	V	Ctg/Gtg	-2.01	0	0	probably_damaging	0.99	neutral	0.51	neutral	1.93	neutral	-0.73	neutral	-1.06	low_impact	1.38	0.71	neutral	0.52	neutral	3.50	23.10	deleterious	0.36	0.5	0.55	disease	0.56	disease	0.54	disease	0.62	disease	2	0.99	deleterious	0.26	neutral	-2	neutral	0.77	deleterious	-2.58	low_impact	0.21	medium_impact	0.19	medium_impact	0.41	0.8	68.28	16.14	0.27	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7983	7983	T	G	MI.6038	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	398	133	L	R	cTg/cGg	0.06	0.02	0	probably_damaging	1	neutral	0.39	neutral	1.87	neutral	-1.8	deleterious	-3.08	low_impact	1.58	0.63	neutral	0.4	neutral	4.32	24.00	deleterious	0.24	0.45	0.38	neutral	0.88	disease	0.68	disease	0.77	disease	5	1	deleterious	0.2	neutral	-2	neutral	0.82	deleterious	-3.52	low_impact	0.1	medium_impact	0.38	medium_impact	0.56	0.8	68.28	16.14	0.32	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7983	7983	T	C	MI.6039	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	398	133	L	P	cTg/cCg	0.06	0.02	0	probably_damaging	1	neutral	0.22	neutral	1.87	neutral	-1.92	deleterious	-3.01	neutral_impact	-0.14	0.71	neutral	0.42	neutral	2.93	22.00	deleterious	0.22	0.45	0.46	neutral	0.85	disease	0.33	neutral	0.2	neutral	6	1	deleterious	0.11	neutral	-2	neutral	0.85	deleterious	-3.52	low_impact	-0.1	medium_impact	-1.24	low_impact	0.46	0.8	68.28	16.14	0.32	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8810	8810	C	A	MI.604	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	284	95	T	N	aCc/aAc	6.84	1	0	probably_damaging	1	deleterious	0	neutral	3.3	deleterious	-3.87	deleterious	-4.58	high_impact	3.63	0.67	neutral	0.13	damaging	3.74	23.30	deleterious	0.26	0.65	0.96	disease	0.63	disease	0.75	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	2.01	high_impact	0.72	0.9	50.44	8.81	0.49	N	0.90	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7983	7983	T	A	MI.6040	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	398	133	L	Q	cTg/cAg	0.06	0.02	0	probably_damaging	1	neutral	0.32	neutral	1.86	neutral	-2.21	deleterious	-2.95	low_impact	1.73	0.69	neutral	0.47	neutral	4.31	24.00	deleterious	0.22	0.45	0.46	neutral	0.71	disease	0.55	disease	0.67	disease	3	1	deleterious	0.16	neutral	-2	neutral	0.78	deleterious	-3.52	low_impact	0.02	medium_impact	0.52	medium_impact	0.49	0.8	68.28	16.14	0.32	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7985	7985	C	G	MI.6041	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	400	134	R	G	Cga/Gga	-8.7	0	0	probably_damaging	1	neutral	0.37	neutral	1.51	deleterious	-3.84	deleterious	-6.93	high_impact	3.72	0.32	damaging	0.23	damaging	4.31	24.00	deleterious	0.26	0.45	0.63	disease	0.8	disease	0.78	disease	0.69	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	0.08	medium_impact	2.38	high_impact	0.44	0.8	68.72	19.77	0.6	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7985	7985	C	T	MI.6042	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	400	134	R	W	Cga/Tga	-8.7	0	0	probably_damaging	1	neutral	0.18	neutral	1.47	deleterious	-6.72	deleterious	-7.92	high_impact	3.98	0.32	damaging	0.1	damaging	5.24	25.60	deleterious	0.37	0.5	0.92	disease	0.89	disease	0.79	disease	0.62	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.16	medium_impact	2.63	high_impact	0.71	0.85	68.72	19.77	0.56	P	1.00	polymorphism	0.99	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7986	7986	G	T	MI.6043	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	401	134	R	L	cGa/cTa	2.83	0.97	0	probably_damaging	1	neutral	0.75	neutral	1.51	deleterious	-3.65	deleterious	-6.93	high_impact	3.83	0.28	damaging	0.28	damaging	4.49	24.30	deleterious	0.3	0.45	0.57	disease	0.91	disease	0.76	disease	0.7	disease	4	1	deleterious	0.38	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.47	medium_impact	2.49	high_impact	0.31	0.8	68.72	19.77	0.86	P	1.00	disease_causing	1	0.08	.	.	.	.	.	pancreatic cancer cell line	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7986	7986	G	A	MI.6044	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	401	134	R	Q	cGa/cAa	2.83	0.97	0	probably_damaging	1	neutral	0.3	neutral	1.54	deleterious	-3.03	deleterious	-3.96	high_impact	3.72	0.31	damaging	0.14	damaging	4.63	24.50	deleterious	0.54	0.6	0.47	neutral	0.85	disease	0.79	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	0	medium_impact	2.38	high_impact	0.94	0.95	68.72	19.77	0.82	P	1.00	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7986	7986	G	C	MI.6045	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	401	134	R	P	cGa/cCa	2.83	0.97	0	probably_damaging	1	neutral	0.24	neutral	1.49	deleterious	-4.58	deleterious	-6.93	high_impact	3.72	0.31	damaging	0.15	damaging	4.37	24.10	deleterious	0.16	0.45	0.71	disease	0.88	disease	0.8	disease	0.72	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.07	medium_impact	2.38	high_impact	0.28	0.8	68.72	19.77	0.74	P	1.00	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7988	7988	C	G	MI.6046	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	403	135	L	V	Ctc/Gtc	-3.63	0	0	probably_damaging	0.99	neutral	0.51	neutral	1.56	neutral	-2.46	deleterious	-2.97	medium_impact	2.85	0.13	damaging	0.01	damaging	3.52	23.10	deleterious	0.46	0.55	0.41	neutral	0.75	disease	0.55	disease	0.63	disease	3	0.99	deleterious	0.26	neutral	1	deleterious	0.77	deleterious	-2.58	low_impact	0.21	medium_impact	1.57	medium_impact	0.66	0.8	68.28	19.43	0.68	P	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7988	7988	C	A	MI.6047	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	403	135	L	I	Ctc/Atc	-3.63	0	0	probably_damaging	1	neutral	0.39	neutral	1.56	neutral	-2.43	neutral	-1.98	medium_impact	3.12	0.17	damaging	0.02	damaging	4.21	23.90	deleterious	0.45	0.55	0.37	neutral	0.73	disease	0.66	disease	0.65	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.75	deleterious	-3.52	low_impact	0.1	medium_impact	1.82	medium_impact	0.70	0.85	68.28	19.43	0.76	P	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7988	7988	C	T	MI.6048	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	403	135	L	F	Ctc/Ttc	-3.63	0	0	probably_damaging	1	neutral	0.7	neutral	1.5	deleterious	-3.51	deleterious	-3.96	medium_impact	2.81	0.12	damaging	0.01	damaging	4.13	23.80	deleterious	0.44	0.55	0.62	disease	0.77	disease	0.67	disease	0.66	disease	3	1	deleterious	0.35	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	0.41	medium_impact	1.53	medium_impact	0.61	0.8	68.28	19.43	0.7	P	0.91	polymorphism	0.99	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7989	7989	T	C	MI.6049	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	404	135	L	P	cTc/cCc	-0.4	0	0	probably_damaging	1	neutral	0.23	neutral	1.46	deleterious	-5.1	deleterious	-6.93	medium_impact	3.23	0.14	damaging	0.01	damaging	4.08	23.70	deleterious	0.18	0.45	0.71	disease	0.86	disease	0.7	disease	0.69	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	-0.09	medium_impact	1.92	medium_impact	0.50	0.8	68.28	19.43	0.71	P	0.99	disease_causing	1	0.10	rs1131692064	Pathogenic	Mitochondrial_diseases	424212	MedGen:C0751651,Orphanet:ORPHA68380	.	.	.	.	T7989C	Rhabdomyolysis	-	+	Reported	2	.	P	P	damaging
chrM	8810	8810	C	G	MI.605	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	284	95	T	S	aCc/aGc	6.84	1	0	probably_damaging	0.99	neutral	0.22	neutral	3.47	neutral	-1.81	deleterious	-3.64	medium_impact	2.25	0.68	neutral	0.17	damaging	3.46	23.00	deleterious	0.31	0.65	0.75	disease	0.28	neutral	0.57	disease	0.53	disease	1	0.99	deleterious	0.12	neutral	1	deleterious	0.76	deleterious	-2.65	low_impact	-0.02	medium_impact	0.83	medium_impact	0.74	0.9	50.44	8.81	0.56	P	0.88	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7989	7989	T	A	MI.6050	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	404	135	L	H	cTc/cAc	-0.4	0	0	probably_damaging	1	neutral	0.54	neutral	1.46	deleterious	-4.97	deleterious	-6.93	high_impact	3.96	0.13	damaging	0.01	damaging	4.45	24.20	deleterious	0.22	0.45	0.69	disease	0.89	disease	0.75	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.24	medium_impact	2.61	high_impact	0.53	0.8	68.28	19.43	0.72	P	0.94	disease_causing	0.56	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7989	7989	T	G	MI.6051	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	404	135	L	R	cTc/cGc	-0.4	0	0	probably_damaging	1	neutral	0.37	neutral	1.49	deleterious	-3.84	deleterious	-5.94	medium_impact	3.15	0.15	damaging	0.01	damaging	4.34	24.00	deleterious	0.19	0.45	0.55	disease	0.92	disease	0.79	disease	0.71	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.08	medium_impact	1.85	medium_impact	0.55	0.8	68.28	19.43	0.78	P	0.99	disease_causing	0.7	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7991	7991	C	T	MI.6052	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	406	136	L	F	Ctt/Ttt	-8.01	0	0	probably_damaging	1	neutral	0.71	neutral	0.98	deleterious	-4.76	deleterious	-3.96	medium_impact	2.9	0.12	damaging	0.02	damaging	4.07	23.70	deleterious	0.45	0.55	0.71	disease	0.75	disease	0.66	disease	0.65	disease	3	1	deleterious	0.36	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	0.42	medium_impact	1.61	medium_impact	0.57	0.8	68.72	19.58	0.65	P	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7991	7991	C	G	MI.6053	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	406	136	L	V	Ctt/Gtt	-8.01	0	0	probably_damaging	0.99	neutral	0.57	neutral	1.04	deleterious	-3.71	deleterious	-2.97	medium_impact	3.02	0.14	damaging	0.01	damaging	3.55	23.10	deleterious	0.45	0.55	0.44	neutral	0.74	disease	0.53	disease	0.6	disease	2	0.99	deleterious	0.29	neutral	1	deleterious	0.78	deleterious	-2.58	low_impact	0.27	medium_impact	1.73	medium_impact	0.63	0.8	68.72	19.58	0.58	P	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7991	7991	C	A	MI.6054	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	406	136	L	I	Ctt/Att	-8.01	0	0	probably_damaging	1	neutral	0.43	neutral	1.05	deleterious	-3.56	neutral	-1.98	medium_impact	2.52	0.18	damaging	0.03	damaging	4.27	24.00	deleterious	0.41	0.5	0.24	neutral	0.67	disease	0.47	neutral	0.22	neutral	6	1	deleterious	0.22	neutral	1	deleterious	0.72	deleterious	-3.52	low_impact	0.14	medium_impact	1.26	medium_impact	0.71	0.85	68.72	19.58	0.64	P	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7992	7992	T	A	MI.6055	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	407	136	L	H	cTt/cAt	-2.48	0	0	probably_damaging	1	neutral	0.54	neutral	0.93	deleterious	-7.03	deleterious	-6.93	high_impact	4.61	0.13	damaging	0.01	damaging	4.19	23.80	deleterious	0.22	0.45	0.78	disease	0.89	disease	0.74	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.24	medium_impact	3.22	high_impact	0.55	0.8	68.72	19.58	0.66	P	0.94	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7992	7992	T	G	MI.6056	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	407	136	L	R	cTt/cGt	-2.48	0	0	probably_damaging	1	neutral	0.51	neutral	0.94	deleterious	-6.03	deleterious	-5.94	high_impact	3.71	0.15	damaging	0.01	damaging	4.28	24.00	deleterious	0.21	0.45	0.83	disease	0.91	disease	0.78	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.21	medium_impact	2.37	high_impact	0.60	0.8	68.72	19.58	0.71	P	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7992	7992	T	C	MI.6057	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	407	136	L	P	cTt/cCt	-2.48	0	0	probably_damaging	1	neutral	0.31	neutral	0.93	deleterious	-6.86	deleterious	-6.93	high_impact	4.61	0.14	damaging	0.02	damaging	4.00	23.60	deleterious	0.18	0.45	0.87	disease	0.86	disease	0.67	disease	0.64	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.01	medium_impact	3.22	high_impact	0.44	0.8	68.72	19.58	0.65	P	0.99	disease_causing	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7994	7994	G	T	MI.6058	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	409	137	D	Y	Gac/Tac	-0.17	0.61	0	possibly_damaging	0.73	neutral	0.61	neutral	1.77	deleterious	-3.92	deleterious	-4.8	medium_impact	3.17	0.62	neutral	0.57	neutral	3.82	23.40	deleterious	0.31	0.45	0.6	disease	0.89	disease	0.67	disease	0.72	disease	4	0.69	neutral	0.44	neutral	0	NA	0.71	deleterious	-1.12	low_impact	0.31	medium_impact	1.87	medium_impact	0.35	0.8	64.76	16.86	0.3	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7994	7994	G	C	MI.6059	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	409	137	D	H	Gac/Cac	-0.17	0.61	0	possibly_damaging	0.57	neutral	0.38	neutral	1.79	neutral	-2.95	deleterious	-2.88	medium_impact	2.48	0.61	neutral	0.5	neutral	3.39	23.00	deleterious	0.39	0.5	0.49	neutral	0.84	disease	0.66	disease	0.71	disease	4	0.64	neutral	0.41	neutral	0	NA	0.57	deleterious	-0.84	medium_impact	0.09	medium_impact	1.22	medium_impact	0.59	0.8	64.76	16.86	0.29	N	0.51	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8812	8812	A	T	MI.606	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	286	96	T	S	Acc/Tcc	-13.52	0	0.01	probably_damaging	0.99	neutral	1	neutral	4.57	neutral	1.33	deleterious	-3.07	low_impact	1.12	0.71	neutral	0.67	neutral	2.70	20.80	deleterious	0.52	0.65	0.4	neutral	0.13	neutral	0.33	neutral	0.25	neutral	5	0.99	deleterious	0.51	deleterious	-2	neutral	0.67	deleterious	-2.65	low_impact	1.98	high_impact	-0.14	medium_impact	0.73	0.9	34.51	7.56	0.3	N	0.88	polymorphism	0.97	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7994	7994	G	A	MI.6060	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	409	137	D	N	Gac/Aac	-0.17	0.61	0	benign	0.15	neutral	0.57	neutral	1.85	neutral	-1.44	neutral	-2.44	low_impact	1.86	0.58	damaging	0.59	neutral	2.45	19.15	deleterious	0.71	0.75	0.34	neutral	0.78	disease	0.51	disease	0.57	disease	1	0.32	neutral	0.71	deleterious	-6	neutral	0.31	neutral	-0.02	medium_impact	0.27	medium_impact	0.64	medium_impact	0.76	0.85	64.76	16.86	0.3	N	0.45	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7995	7995	A	G	MI.6061	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	410	137	D	G	gAc/gGc	9.29	1	0	benign	0.14	neutral	0.46	neutral	1.81	neutral	-2.25	deleterious	-4.42	low_impact	1.75	0.58	damaging	0.51	neutral	2.32	18.29	deleterious	0.37	0.5	0.45	neutral	0.84	disease	0.63	disease	0.7	disease	4	0.46	neutral	0.66	deleterious	-6	neutral	0.29	neutral	0.01	medium_impact	0.17	medium_impact	0.54	medium_impact	0.46	0.8	64.76	16.86	0.52	N	0.86	disease_causing	0.87	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7995	7995	A	C	MI.6062	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	410	137	D	A	gAc/gCc	9.29	1	0	benign	0.1	neutral	0.81	neutral	1.88	neutral	-1.08	deleterious	-3.77	low_impact	1.18	0.63	neutral	0.65	neutral	1.95	15.89	deleterious	0.32	0.5	0.2	neutral	0.85	disease	0.61	disease	0.7	disease	4	0.09	neutral	0.86	deleterious	-6	neutral	0.25	neutral	0.17	medium_impact	0.55	medium_impact	0	medium_impact	0.36	0.8	64.76	16.86	0.48	P	0.59	disease_causing	0.83	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7995	7995	A	T	MI.6063	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	410	137	D	V	gAc/gTc	9.29	1	0	benign	0.38	neutral	0.56	neutral	1.79	neutral	-2.99	deleterious	-4.73	low_impact	1.52	0.59	damaging	0.62	neutral	2.21	17.58	deleterious	0.32	0.5	0.25	neutral	0.9	disease	0.63	disease	0.72	disease	4	0.38	neutral	0.59	deleterious	-6	neutral	0.36	neutral	-0.52	medium_impact	0.26	medium_impact	0.32	medium_impact	0.38	0.8	64.76	16.86	0.45	N	0.82	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7996	7996	C	G	MI.6064	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	411	137	D	E	gaC/gaG	8.59	1	0	benign	0	neutral	1	neutral	2.19	neutral	0.91	neutral	1.56	neutral_impact	-1.04	0.85	neutral	0.95	neutral	-0.70	0.07	neutral	0.61	0.65	0.36	neutral	0.24	neutral	0.18	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.16	neutral	2.08	high_impact	1.86	high_impact	-2.08	low_impact	0.44	0.8	64.76	16.86	0.49	N	0.01	polymorphism	0.87	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7996	7996	C	A	MI.6065	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	411	137	D	E	gaC/gaA	8.59	1	0	benign	0	neutral	1	neutral	2.19	neutral	0.91	neutral	1.56	neutral_impact	-1.04	0.85	neutral	0.95	neutral	-0.34	0.55	neutral	0.61	0.65	0.36	neutral	0.24	neutral	0.18	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.16	neutral	2.08	high_impact	1.86	high_impact	-2.08	low_impact	0.44	0.8	64.76	16.86	0.5	N	0.01	polymorphism	0.87	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	7997	7997	G	A	MI.6066	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	412	138	V	I	Gtt/Att	1.68	1	0	probably_damaging	0.99	neutral	0.22	neutral	1.76	neutral	-1.25	neutral	-0.99	high_impact	4.45	0.44	damaging	0.11	damaging	3.78	23.40	deleterious	0.67	0.7	0.59	disease	0.59	disease	0.73	disease	0.69	disease	4	0.99	deleterious	0.12	neutral	2	deleterious	0.68	deleterious	-2.58	low_impact	-0.1	medium_impact	3.07	high_impact	0.75	0.85	68.72	19.45	0.67	P	0.30	disease_causing	0.52	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7997	7997	G	C	MI.6067	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	412	138	V	L	Gtt/Ctt	1.68	1	0	probably_damaging	0.99	neutral	0.39	neutral	1.71	neutral	-1.6	deleterious	-2.53	medium_impact	3.48	0.41	damaging	0.12	damaging	3.66	23.20	deleterious	0.54	0.6	0.53	disease	0.76	disease	0.7	disease	0.66	disease	3	0.99	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-2.58	low_impact	0.1	medium_impact	2.16	high_impact	0.65	0.8	68.72	19.45	0.64	P	0.23	disease_causing	0.79	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7997	7997	G	T	MI.6068	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	412	138	V	F	Gtt/Ttt	1.68	1	0	probably_damaging	1	neutral	0.12	neutral	1.65	neutral	-2.35	deleterious	-4.29	high_impact	4.45	0.38	damaging	0.11	damaging	3.96	23.60	deleterious	0.21	0.45	0.72	disease	0.87	disease	0.75	disease	0.72	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.27	medium_impact	3.07	high_impact	0.70	0.85	68.72	19.45	0.68	P	0.94	disease_causing	0.98	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7998	7998	T	A	MI.6069	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	413	138	V	D	gTt/gAt	3.29	1	0	probably_damaging	1	neutral	0.65	neutral	1.57	deleterious	-4.9	deleterious	-5.69	high_impact	3.75	0.38	damaging	0.11	damaging	4.52	24.30	deleterious	0.15	0.4	0.65	disease	0.9	disease	0.8	disease	0.73	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	0.35	medium_impact	2.41	high_impact	0.55	0.8	68.72	19.45	0.68	P	0.90	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8812	8812	A	G	MI.607	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	286	96	T	A	Acc/Gcc	-13.52	0	0.01	probably_damaging	0.99	neutral	0.14	neutral	4.56	neutral	1.25	deleterious	-3.89	low_impact	1.88	0.84	neutral	0.67	neutral	3.88	23.50	deleterious	0.62	0.7	0.28	neutral	0.31	neutral	0.42	neutral	0.42	neutral	2	0.99	deleterious	0.08	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	-0.15	medium_impact	0.51	medium_impact	0.43	0.9	34.51	7.56	0.4	N	0.63	polymorphism	0.93	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7998	7998	T	G	MI.6070	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	413	138	V	G	gTt/gGt	3.29	1	0	probably_damaging	1	neutral	0.39	neutral	1.58	deleterious	-4.34	deleterious	-5.7	high_impact	3.64	0.45	damaging	0.14	damaging	3.92	23.50	deleterious	0.27	0.45	0.36	neutral	0.83	disease	0.76	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.74	deleterious	-3.52	low_impact	0.1	medium_impact	2.31	high_impact	0.32	0.8	68.72	19.45	0.52	N	0.84	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	7998	7998	T	C	MI.6071	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	413	138	V	A	gTt/gCt	3.29	1	0	probably_damaging	1	neutral	0.76	neutral	1.64	neutral	-2.58	deleterious	-2.81	medium_impact	3.06	0.71	neutral	0.61	neutral	2.33	18.37	deleterious	0.54	0.6	0.49	neutral	0.71	disease	0.66	disease	0.36	neutral	3	1	deleterious	0.38	neutral	1	deleterious	0.75	deleterious	-3.52	low_impact	0.48	medium_impact	1.76	medium_impact	0.38	0.8	68.72	19.45	0.39	N	0.59	disease_causing	0.93	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8000	8000	G	A	MI.6072	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	415	139	D	N	Gac/Aac	-11.7	0	0	probably_damaging	1	neutral	0.37	neutral	1.66	neutral	-2.58	deleterious	-4.37	medium_impact	2.96	0.2	damaging	0.02	damaging	4.30	24.00	deleterious	0.66	0.7	0.54	disease	0.85	disease	0.65	disease	0.55	disease	1	1	deleterious	0.19	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	0.08	medium_impact	1.67	medium_impact	0.74	0.85	68.72	19.59	0.65	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8000	8000	G	T	MI.6073	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	415	139	D	Y	Gac/Tac	-11.7	0	0	probably_damaging	1	neutral	1	neutral	1.63	deleterious	-3.35	deleterious	-8.49	high_impact	4.06	0.17	damaging	0.02	damaging	4.01	23.60	deleterious	0.27	0.45	0.78	disease	0.94	disease	0.75	disease	0.75	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.52	low_impact	1.86	high_impact	2.7	high_impact	0.27	0.8	68.72	19.59	0.44	N	0.99	polymorphism	0.98	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8000	8000	G	C	MI.6074	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	415	139	D	H	Gac/Cac	-11.7	0	0	probably_damaging	1	neutral	0.56	neutral	1.61	deleterious	-3.89	deleterious	-6.49	high_impact	4.26	0.12	damaging	0.02	damaging	3.71	23.30	deleterious	0.35	0.5	0.69	disease	0.9	disease	0.74	disease	0.7	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.26	medium_impact	2.89	high_impact	0.44	0.8	68.72	19.59	0.55	P	0.98	polymorphism	0.99	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8001	8001	A	T	MI.6075	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	416	139	D	V	gAc/gTc	6.06	1	0	probably_damaging	1	neutral	0.55	neutral	1.62	deleterious	-3.59	deleterious	-8.53	high_impact	4.61	0.12	damaging	0.01	damaging	3.86	23.50	deleterious	0.31	0.45	0.36	neutral	0.94	disease	0.7	disease	0.76	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	0.25	medium_impact	3.22	high_impact	0.22	0.8	68.72	19.59	0.75	P	0.99	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8001	8001	A	C	MI.6076	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	416	139	D	A	gAc/gCc	6.06	1	0	probably_damaging	1	neutral	0.57	neutral	1.67	neutral	-2.47	deleterious	-7.5	medium_impact	2.4	0.23	damaging	0.1	damaging	3.78	23.40	deleterious	0.35	0.5	0.26	neutral	0.9	disease	0.69	disease	0.69	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	0.27	medium_impact	1.15	medium_impact	0.37	0.8	68.72	19.59	0.78	P	0.96	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8001	8001	A	G	MI.6077	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	416	139	D	G	gAc/gGc	6.06	1	0	probably_damaging	1	neutral	0.36	neutral	1.63	deleterious	-3.31	deleterious	-6.43	high_impact	3.63	0.12	damaging	0.03	damaging	4.13	23.80	deleterious	0.34	0.5	0.54	disease	0.88	disease	0.72	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	0.07	medium_impact	2.3	high_impact	0.32	0.8	68.72	19.59	0.86	P	0.97	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8002	8002	C	G	MI.6078	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	417	139	D	E	gaC/gaG	6.98	1	0	probably_damaging	0.98	neutral	0.4	neutral	1.72	neutral	-1.72	deleterious	-3.75	high_impact	3.81	0.17	damaging	0.03	damaging	3.97	23.60	deleterious	0.53	0.6	0.42	neutral	0.85	disease	0.61	disease	0.68	disease	4	0.98	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-2.3	low_impact	0.11	medium_impact	2.47	high_impact	0.54	0.8	68.72	19.59	0.88	P	0.95	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8002	8002	C	A	MI.6079	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	417	139	D	E	gaC/gaA	6.98	1	0	probably_damaging	0.98	neutral	0.4	neutral	1.72	neutral	-1.72	deleterious	-3.75	high_impact	3.81	0.17	damaging	0.03	damaging	4.29	24.00	deleterious	0.53	0.6	0.42	neutral	0.85	disease	0.61	disease	0.68	disease	4	0.98	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-2.3	low_impact	0.11	medium_impact	2.47	high_impact	0.54	0.8	68.72	19.59	0.88	P	0.95	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8812	8812	A	C	MI.608	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	286	96	T	P	Acc/Ccc	-13.52	0	0.01	probably_damaging	1	deleterious	0.01	neutral	4.28	neutral	-2.58	deleterious	-5.06	medium_impact	3.41	0.58	damaging	0.47	neutral	3.93	23.50	deleterious	0.22	0.65	0.84	disease	0.76	disease	0.77	disease	0.74	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.6	low_impact	-0.84	medium_impact	1.83	medium_impact	0.52	0.9	34.51	7.56	0.34	N	0.99	polymorphism	0.71	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8003	8003	A	G	MI.6080	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	418	140	N	D	Aat/Gat	-2.01	0	0	probably_damaging	0.99	neutral	0.29	neutral	1.67	neutral	-2.11	deleterious	-3.25	medium_impact	3.5	0.51	damaging	0.16	damaging	3.39	23.00	deleterious	0.67	0.7	0.66	disease	0.78	disease	0.66	disease	0.66	disease	3	0.99	deleterious	0.15	neutral	1	deleterious	0.77	deleterious	-2.58	low_impact	-0.01	medium_impact	2.18	high_impact	0.50	0.8	67.84	19.51	0.34	N	0.97	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8003	8003	A	T	MI.6081	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	418	140	N	Y	Aat/Tat	-2.01	0	0	probably_damaging	1	neutral	1	neutral	1.58	deleterious	-4.84	deleterious	-2.85	medium_impact	3.15	0.56	damaging	0.23	damaging	3.21	22.70	deleterious	0.32	0.5	0.86	disease	0.85	disease	0.66	disease	0.61	disease	2	1	deleterious	0.5	deleterious	1	deleterious	0.84	deleterious	-3.52	low_impact	1.86	high_impact	1.85	medium_impact	0.37	0.8	67.84	19.51	0.22	N	0.98	polymorphism	0.94	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8003	8003	A	C	MI.6082	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	418	140	N	H	Aat/Cat	-2.01	0	0	probably_damaging	1	neutral	0.58	neutral	1.61	deleterious	-3.35	neutral	1.18	medium_impact	2.1	0.7	neutral	0.67	neutral	0.66	8.58	deleterious	0.53	0.6	0.46	neutral	0.58	disease	0.45	neutral	0.16	neutral	7	1	deleterious	0.29	neutral	1	deleterious	0.74	deleterious	-3.52	low_impact	0.28	medium_impact	0.86	medium_impact	0.41	0.8	67.84	19.51	0.3	N	0.94	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8004	8004	A	C	MI.6083	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	419	140	N	T	aAt/aCt	3.52	0.99	0	probably_damaging	0.99	neutral	0.4	neutral	1.63	neutral	-2.75	deleterious	-4.1	medium_impact	2.35	0.52	damaging	0.2	damaging	3.11	22.50	deleterious	0.48	0.55	0.62	disease	0.78	disease	0.58	disease	0.54	disease	1	0.99	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	0.11	medium_impact	1.1	medium_impact	0.40	0.8	67.84	19.51	0.41	N	0.92	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8004	8004	A	G	MI.6084	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	419	140	N	S	aAt/aGt	3.52	0.99	0	probably_damaging	0.97	neutral	0.41	neutral	1.67	neutral	-2.22	deleterious	-3.11	medium_impact	2.55	0.55	damaging	0.2	damaging	1.43	12.96	neutral	0.71	0.75	0.56	disease	0.8	disease	0.58	disease	0.55	disease	1	0.97	neutral	0.22	neutral	1	deleterious	0.78	deleterious	-2.13	low_impact	0.12	medium_impact	1.29	medium_impact	0.31	0.8	67.84	19.51	0.39	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8004	8004	A	T	MI.6085	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	419	140	N	I	aAt/aTt	3.52	0.99	0	probably_damaging	1	neutral	0.4	neutral	1.57	deleterious	-5.76	deleterious	-5.95	medium_impact	3.5	0.57	damaging	0.16	damaging	3.82	23.40	deleterious	0.3	0.45	0.84	disease	0.88	disease	0.67	disease	0.63	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	0.11	medium_impact	2.18	high_impact	0.27	0.8	67.84	19.51	0.42	N	0.97	polymorphism	0.96	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8005	8005	T	G	MI.6086	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	420	140	N	K	aaT/aaG	6.98	1	0	probably_damaging	1	neutral	0.29	neutral	1.65	neutral	-2.4	deleterious	-3.66	medium_impact	2.6	0.51	damaging	0.14	damaging	3.92	23.50	deleterious	0.63	0.65	0.47	neutral	0.86	disease	0.66	disease	0.69	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.01	medium_impact	1.33	medium_impact	0.59	0.8	67.84	19.51	0.53	P	0.99	polymorphism	0.94	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8005	8005	T	A	MI.6087	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	420	140	N	K	aaT/aaA	6.98	1	0	probably_damaging	1	neutral	0.29	neutral	1.65	neutral	-2.4	deleterious	-3.66	medium_impact	2.6	0.51	damaging	0.14	damaging	4.14	23.80	deleterious	0.63	0.65	0.47	neutral	0.86	disease	0.66	disease	0.69	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.01	medium_impact	1.33	medium_impact	0.59	0.8	67.84	19.51	0.55	P	0.99	polymorphism	0.94	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8006	8006	C	T	MI.6088	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	421	141	R	W	Cga/Tga	-7.32	0	0	probably_damaging	1	neutral	0.19	neutral	1.78	deleterious	-5.54	deleterious	-7.53	high_impact	3.55	0.33	damaging	0.1	damaging	5.26	25.70	deleterious	0.3	0.45	0.94	disease	0.91	disease	0.71	disease	0.61	disease	2	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.14	medium_impact	2.22	high_impact	0.71	0.85	68.28	19	0.46	N	1.00	polymorphism	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8006	8006	C	G	MI.6089	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	421	141	R	G	Cga/Gga	-7.32	0	0	probably_damaging	1	neutral	0.34	neutral	1.82	neutral	-2.36	deleterious	-6.49	high_impact	3.55	0.3	damaging	0.23	damaging	4.29	24.00	deleterious	0.25	0.45	0.45	neutral	0.84	disease	0.7	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	0.05	medium_impact	2.22	high_impact	0.31	0.8	68.28	19	0.5	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8813	8813	C	A	MI.609	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	287	96	T	N	aCc/aAc	8.69	1	0	probably_damaging	1	deleterious	0.01	neutral	4.34	neutral	-0.67	deleterious	-4.13	high_impact	3.62	0.67	neutral	0.54	neutral	3.64	23.20	deleterious	0.43	0.65	0.38	neutral	0.66	disease	0.7	disease	0.69	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.71	deleterious	-3.6	low_impact	-0.84	medium_impact	2.01	high_impact	0.77	0.9	34.51	7.56	0.52	P	0.90	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8007	8007	G	A	MI.6090	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	422	141	R	Q	cGa/cAa	4.44	0.99	0	probably_damaging	1	neutral	0.29	neutral	1.87	neutral	-0.76	deleterious	-3.66	medium_impact	3.21	0.34	damaging	0.13	damaging	4.57	24.40	deleterious	0.34	0.5	0.53	disease	0.85	disease	0.7	disease	0.71	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.01	medium_impact	1.9	medium_impact	0.74	0.85	68.28	19	0.75	P	1.00	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8007	8007	G	T	MI.6091	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	422	141	R	L	cGa/cTa	4.44	0.99	0	probably_damaging	1	neutral	0.66	neutral	1.83	neutral	-2.23	deleterious	-6.62	medium_impact	3.12	0.29	damaging	0.27	damaging	4.36	24.10	deleterious	0.27	0.45	0.69	disease	0.92	disease	0.68	disease	0.71	disease	4	1	deleterious	0.33	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	0.36	medium_impact	1.82	medium_impact	0.25	0.8	68.28	19	0.88	P	1.00	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8007	8007	G	C	MI.6092	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	422	141	R	P	cGa/cCa	4.44	0.99	0	probably_damaging	1	neutral	0.2	neutral	1.83	neutral	-0.51	deleterious	-6.55	low_impact	1.89	0.33	damaging	0.14	damaging	4.31	24.00	deleterious	0.14	0.4	0.75	disease	0.91	disease	0.69	disease	0.69	disease	4	1	deleterious	0.1	neutral	-2	neutral	0.89	deleterious	-3.52	low_impact	-0.13	medium_impact	0.67	medium_impact	0.29	0.8	68.28	19	0.63	P	1.00	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8009	8009	G	T	MI.6093	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	424	142	V	L	Gta/Tta	-1.55	0	0	probably_damaging	0.97	neutral	0.74	neutral	2.22	neutral	1.1	neutral	-0.07	neutral_impact	-1.06	0.75	neutral	0.87	neutral	2.59	20.10	deleterious	0.47	0.55	0.4	neutral	0.36	neutral	0.43	neutral	0.45	neutral	1	0.97	neutral	0.39	neutral	-2	neutral	0.67	deleterious	-2.13	low_impact	0.46	medium_impact	-2.1	low_impact	0.85	0.9	31.72	28.73	0.27	N	0.23	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8009	8009	G	A	MI.6094	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	424	142	V	M	Gta/Ata	-1.55	0	0	probably_damaging	1	neutral	0.32	neutral	1.93	neutral	-1.36	neutral	1.6	neutral_impact	-0.7	0.75	neutral	0.79	neutral	1.08	11.11	neutral	0.52	0.6	0.48	neutral	0.13	neutral	0.33	neutral	0.2	neutral	6	1	deleterious	0.16	neutral	-2	neutral	0.69	deleterious	-3.52	low_impact	0.02	medium_impact	-1.76	low_impact	0.78	0.85	31.72	28.73	0.48	N	0.87	disease_causing_automatic	0	0.00	rs199474826	Pathogenic	Familial_colorectal_cancer	24698	MedGen:CN029768	colorectal tumor	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	8009	8009	G	C	MI.6095	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	424	142	V	L	Gta/Cta	-1.55	0	0	probably_damaging	0.97	neutral	0.74	neutral	2.22	neutral	1.1	neutral	-0.07	neutral_impact	-1.06	0.75	neutral	0.87	neutral	2.46	19.18	deleterious	0.47	0.55	0.4	neutral	0.36	neutral	0.43	neutral	0.45	neutral	1	0.97	neutral	0.39	neutral	-2	neutral	0.67	deleterious	-2.13	low_impact	0.46	medium_impact	-2.1	low_impact	0.85	0.9	31.72	28.73	0.27	N	0.23	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8010	8010	T	A	MI.6096	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	425	142	V	E	gTa/gAa	0.52	0.09	0	probably_damaging	1	neutral	0.27	neutral	1.87	deleterious	-4.31	deleterious	-3.75	medium_impact	2.74	0.58	damaging	0.43	neutral	5.04	25.20	deleterious	0.12	0.4	0.78	disease	0.8	disease	0.77	disease	0.71	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	-0.03	medium_impact	1.46	medium_impact	0.44	0.8	31.72	28.73	0.38	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8010	8010	T	C	MI.6097	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	425	142	V	A	gTa/gCa	0.52	0.09	0	probably_damaging	1	neutral	0.51	neutral	1.91	neutral	-2.16	neutral	-2.43	low_impact	1.54	0.74	neutral	0.88	neutral	2.57	19.90	deleterious	0.4	0.5	0.34	neutral	0.33	neutral	0.52	disease	0.46	neutral	1	1	deleterious	0.26	neutral	-2	neutral	0.71	deleterious	-3.52	low_impact	0.21	medium_impact	0.34	medium_impact	0.63	0.8	31.72	28.73	0.4	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	T8010C	Developmental delay, ataxia, seizure, hypotonia, lactic acidosis	-	+	Reported	1	.	P	P	neutral
chrM	8010	8010	T	G	MI.6098	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	425	142	V	G	gTa/gGa	0.52	0.09	0	probably_damaging	1	neutral	0.36	neutral	1.87	deleterious	-4.06	deleterious	-4.74	medium_impact	2.39	0.61	neutral	0.57	neutral	3.96	23.60	deleterious	0.15	0.4	0.76	disease	0.61	disease	0.7	disease	0.72	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.07	medium_impact	1.14	medium_impact	0.64	0.8	31.72	28.73	0.35	N	0.84	disease_causing	0.78	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8012	8012	G	C	MI.6099	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	427	143	V	L	Gta/Cta	-10.32	0	0	probably_damaging	0.97	neutral	0.48	neutral	1.78	neutral	-2.75	deleterious	-2.6	medium_impact	2.34	0.5	damaging	0.47	neutral	3.61	23.20	deleterious	0.38	0.5	0.55	disease	0.7	disease	0.6	disease	0.55	disease	1	0.97	neutral	0.26	neutral	1	deleterious	0.75	deleterious	-2.13	low_impact	0.19	medium_impact	1.09	medium_impact	0.77	0.85	69.16	16.28	0.35	N	0.23	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8553	8553	C	A	MI.61	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	27	9	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.92	neutral	0.06	neutral	3.94	neutral	-0.84	deleterious	-5.27	medium_impact	2.34	0.57	damaging	0.59	neutral	8.72	35.00	deleterious	0.4	0.65	0.6	disease	0.77	disease	0.82	disease	0.8	disease	6	0.98	deleterious	0.07	neutral	1	deleterious	0.76	deleterious	-1.76	low_impact	-0.38	medium_impact	0.91	medium_impact	0.44	0.9	49.56	8.77	0.59	P	0.89	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8813	8813	C	G	MI.610	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	287	96	T	S	aCc/aGc	8.69	1	0	probably_damaging	0.99	neutral	1	neutral	4.57	neutral	1.33	deleterious	-3.07	low_impact	1.12	0.71	neutral	0.67	neutral	2.43	19.03	deleterious	0.52	0.65	0.4	neutral	0.13	neutral	0.33	neutral	0.25	neutral	5	0.99	deleterious	0.51	deleterious	-2	neutral	0.67	deleterious	-2.65	low_impact	1.98	high_impact	-0.14	medium_impact	0.73	0.9	34.51	7.56	0.46	N	0.88	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8012	8012	G	A	MI.6100	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	427	143	V	M	Gta/Ata	-10.32	0	0	probably_damaging	1	neutral	0.24	neutral	1.7	deleterious	-4.06	deleterious	-2.73	medium_impact	2.77	0.53	damaging	0.49	neutral	3.78	23.40	deleterious	0.38	0.5	0.7	disease	0.65	disease	0.49	neutral	0.33	neutral	3	1	deleterious	0.12	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	-0.07	medium_impact	1.49	medium_impact	0.71	0.85	69.16	16.28	0.38	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8012	8012	G	T	MI.6101	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	427	143	V	L	Gta/Tta	-10.32	0	0	probably_damaging	0.97	neutral	0.48	neutral	1.78	neutral	-2.75	deleterious	-2.6	medium_impact	2.34	0.5	damaging	0.47	neutral	3.77	23.40	deleterious	0.38	0.5	0.55	disease	0.7	disease	0.6	disease	0.55	disease	1	0.97	neutral	0.26	neutral	1	deleterious	0.75	deleterious	-2.13	low_impact	0.19	medium_impact	1.09	medium_impact	0.77	0.85	69.16	16.28	0.35	N	0.23	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8013	8013	T	A	MI.6102	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	428	143	V	E	gTa/gAa	3.52	1	0	probably_damaging	1	neutral	1	neutral	1.71	deleterious	-3.76	deleterious	-5.71	high_impact	3.58	0.43	damaging	0.34	neutral	4.89	24.90	deleterious	0.21	0.45	0.84	disease	0.9	disease	0.74	disease	0.67	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.89	deleterious	-3.52	low_impact	1.86	high_impact	2.25	high_impact	0.43	0.8	69.16	16.28	0.63	P	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8013	8013	T	G	MI.6103	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	428	143	V	G	gTa/gGa	3.52	1	0	probably_damaging	1	neutral	0.41	neutral	1.68	deleterious	-4.78	deleterious	-6.69	high_impact	4.13	0.55	damaging	0.53	neutral	3.89	23.50	deleterious	0.28	0.45	0.84	disease	0.82	disease	0.68	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.12	medium_impact	2.77	high_impact	0.33	0.8	69.16	16.28	0.45	N	0.84	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8013	8013	T	C	MI.6104	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	428	143	V	A	gTa/gCa	3.52	1	0	probably_damaging	1	neutral	0.78	neutral	1.76	deleterious	-3.04	deleterious	-3.77	medium_impact	2.88	0.55	damaging	0.57	neutral	3.68	23.30	deleterious	0.38	0.5	0.47	neutral	0.67	disease	0.62	disease	0.57	disease	1	1	deleterious	0.39	neutral	1	deleterious	0.75	deleterious	-3.52	low_impact	0.51	medium_impact	1.6	medium_impact	0.40	0.8	69.16	16.28	0.43	N	0.59	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8015	8015	C	A	MI.6105	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	430	144	L	I	Ctc/Atc	-20	0	0	probably_damaging	0.99	neutral	0.45	neutral	1.67	neutral	-1.12	neutral	0.62	neutral_impact	0.62	0.75	neutral	0.66	neutral	2.18	17.37	deleterious	0.38	0.5	0.27	neutral	0.44	neutral	0.24	neutral	0.43	neutral	1	0.99	deleterious	0.23	neutral	-2	neutral	0.71	deleterious	-2.58	low_impact	0.16	medium_impact	-0.52	medium_impact	0.81	0.85	68.28	18.94	0.4	N	0.63	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8015	8015	C	T	MI.6106	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	430	144	L	F	Ctc/Ttc	-20	0	0	probably_damaging	1	neutral	0.7	neutral	1.47	deleterious	-3.86	neutral	-2.29	medium_impact	2.52	0.42	damaging	0.15	damaging	4.04	23.70	deleterious	0.44	0.55	0.49	neutral	0.72	disease	0.52	disease	0.46	neutral	1	1	deleterious	0.35	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.41	medium_impact	1.26	medium_impact	0.71	0.85	68.28	18.94	0.3	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8015	8015	C	G	MI.6107	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	430	144	L	V	Ctc/Gtc	-20	0	0	probably_damaging	0.98	neutral	0.66	neutral	1.71	neutral	-0.58	neutral	0.75	neutral_impact	0.66	0.75	neutral	0.66	neutral	0.79	9.43	deleterious	0.46	0.55	0.32	neutral	0.47	neutral	0.25	neutral	0.43	neutral	1	0.98	deleterious	0.34	neutral	-2	neutral	0.74	deleterious	-2.3	low_impact	0.36	medium_impact	-0.49	medium_impact	0.74	0.85	68.28	18.94	0.32	N	0.66	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8016	8016	T	A	MI.6108	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	431	144	L	H	cTc/cAc	-3.63	0	0	probably_damaging	1	neutral	0.51	neutral	1.4	deleterious	-6.46	deleterious	-4.37	high_impact	3.96	0.46	damaging	0.15	damaging	4.41	24.10	deleterious	0.13	0.4	0.93	disease	0.87	disease	0.72	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.21	medium_impact	2.61	high_impact	0.52	0.8	68.28	18.94	0.35	N	0.94	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8016	8016	T	G	MI.6109	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	431	144	L	R	cTc/cGc	-3.63	0	0	probably_damaging	1	neutral	0.39	neutral	1.41	deleterious	-5.86	deleterious	-3.95	high_impact	3.96	0.35	damaging	0.12	damaging	4.29	24.00	deleterious	0.13	0.4	0.9	disease	0.92	disease	0.75	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	0.1	medium_impact	2.61	high_impact	0.40	0.8	68.28	18.94	0.48	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8813	8813	C	T	MI.611	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	287	96	T	I	aCc/aTc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	4.29	neutral	-2.13	deleterious	-5.08	high_impact	3.96	0.71	neutral	0.6	neutral	3.97	23.60	deleterious	0.39	0.65	0.89	disease	0.72	disease	0.7	disease	0.7	disease	4	1	deleterious	0	deleterious	6	deleterious	0.79	deleterious	-3.6	low_impact	-1.4	low_impact	2.3	high_impact	0.74	0.9	34.51	7.56	0.52	P	0.97	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8016	8016	T	C	MI.6110	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	431	144	L	P	cTc/cCc	-3.63	0	0	probably_damaging	1	neutral	0.3	neutral	1.4	deleterious	-6.34	deleterious	-3.83	high_impact	3.96	0.33	damaging	0.09	damaging	4.06	23.70	deleterious	0.14	0.4	0.92	disease	0.9	disease	0.65	disease	0.68	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	0	medium_impact	2.61	high_impact	0.35	0.8	68.28	18.94	0.4	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8018	8018	C	G	MI.6111	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	433	145	P	A	Ccg/Gcg	-11.24	0	0	probably_damaging	1	neutral	0.51	neutral	0.38	deleterious	-5.98	deleterious	-7.84	high_impact	4.38	0.15	damaging	0.11	damaging	3.15	22.60	deleterious	0.22	0.45	0.88	disease	0.84	disease	0.74	disease	0.66	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.21	medium_impact	3	high_impact	0.60	0.8	68.28	19.5	0.58	P	0.90	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8018	8018	C	T	MI.6112	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	433	145	P	S	Ccg/Tcg	-11.24	0	0	probably_damaging	1	neutral	0.42	neutral	0.37	deleterious	-6.42	deleterious	-7.83	high_impact	4.72	0.11	damaging	0.03	damaging	3.98	23.60	deleterious	0.27	0.45	0.91	disease	0.9	disease	0.74	disease	0.66	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.13	medium_impact	3.32	high_impact	0.21	0.8	68.28	19.5	0.58	P	0.94	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8018	8018	C	A	MI.6113	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	433	145	P	T	Ccg/Acg	-11.24	0	0	probably_damaging	1	neutral	0.41	neutral	0.35	deleterious	-7	deleterious	-7.84	high_impact	4.17	0.12	damaging	0.02	damaging	3.75	23.30	deleterious	0.25	0.45	0.92	disease	0.89	disease	0.75	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.12	medium_impact	2.8	high_impact	0.58	0.8	68.28	19.5	0.51	P	0.96	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8019	8019	C	A	MI.6114	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	434	145	P	Q	cCg/cAg	5.6	1	0	probably_damaging	1	neutral	0.31	neutral	0.35	deleterious	-7.07	deleterious	-7.84	high_impact	4.38	0.11	damaging	0.03	damaging	4.16	23.80	deleterious	0.17	0.45	0.97	disease	0.9	disease	0.77	disease	0.66	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.01	medium_impact	3	high_impact	0.52	0.8	68.28	19.5	0.8	P	0.88	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8019	8019	C	G	MI.6115	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	434	145	P	R	cCg/cGg	5.6	1	0	probably_damaging	1	neutral	0.4	neutral	0.35	deleterious	-7.24	deleterious	-8.82	high_impact	4.72	0.12	damaging	0.02	damaging	3.70	23.30	deleterious	0.2	0.45	0.97	disease	0.94	disease	0.83	disease	0.68	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	0.11	medium_impact	3.32	high_impact	0.44	0.8	68.28	19.5	0.77	P	0.85	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8019	8019	C	T	MI.6116	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	434	145	P	L	cCg/cTg	5.6	1	0	probably_damaging	1	neutral	0.68	neutral	0.36	deleterious	-6.5	deleterious	-9.8	high_impact	3.83	0.08	damaging	0.02	damaging	4.51	24.30	deleterious	0.26	0.45	0.84	disease	0.91	disease	0.73	disease	0.68	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.39	medium_impact	2.49	high_impact	0.64	0.8	68.28	19.5	0.73	P	0.92	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8021	8021	A	G	MI.6117	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	436	146	I	V	Att/Gtt	-10.08	0	0	benign	0	neutral	0.7	neutral	2.12	neutral	2.31	neutral	0.27	neutral_impact	-1.06	0.89	neutral	0.96	neutral	-0.25	0.87	neutral	0.71	0.75	0.36	neutral	0.29	neutral	0.2	neutral	0.45	neutral	1	0.29	neutral	0.85	deleterious	-6	neutral	0.14	neutral	2.08	high_impact	0.41	medium_impact	-2.1	low_impact	0.28	0.8	29.07	74.35	0.37	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	A8021G	Asthenozoospermia	+	-	Reported	1	.	P	P	neutral
chrM	8021	8021	A	C	MI.6118	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	436	146	I	L	Att/Ctt	-10.08	0	0	benign	0.04	neutral	0.88	neutral	2.04	neutral	0.27	neutral	0.18	neutral_impact	-0.04	0.71	neutral	0.64	neutral	0.86	9.83	deleterious	0.52	0.6	0.36	neutral	0.37	neutral	0.19	neutral	0.46	neutral	1	0.05	neutral	0.92	deleterious	-6	neutral	0.16	neutral	0.57	medium_impact	0.68	medium_impact	-1.14	low_impact	0.55	0.8	29.07	74.35	0.37	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8021	8021	A	T	MI.6119	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	436	146	I	F	Att/Ttt	-10.08	0	0	benign	0.38	neutral	0.7	neutral	1.99	neutral	-1.49	neutral	-1.42	neutral_impact	-0.96	0.69	neutral	0.53	neutral	2.45	19.12	deleterious	0.58	0.65	0.29	neutral	0.44	neutral	0.18	neutral	0.43	neutral	1	0.29	neutral	0.66	deleterious	-6	neutral	0.40	neutral	-0.52	medium_impact	0.41	medium_impact	-2.01	low_impact	0.42	0.8	29.07	74.35	0.35	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8815	8815	C	A	MI.612	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	289	97	Q	K	Caa/Aaa	-10.28	0	0	probably_damaging	0.97	deleterious	0.01	neutral	4.35	neutral	-0.52	deleterious	-3.44	high_impact	3.98	0.58	damaging	0.14	damaging	3.97	23.60	deleterious	0.53	0.65	0.46	neutral	0.76	disease	0.72	disease	0.69	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.75	deleterious	-2.19	low_impact	-0.84	medium_impact	2.31	high_impact	0.66	0.9	48.23	8.28	0.3	N	0.99	polymorphism	0.65	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8022	8022	T	A	MI.6120	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	437	146	I	N	aTt/aAt	1.91	0	0	possibly_damaging	0.8	neutral	0.56	neutral	1.93	neutral	-1.21	deleterious	-2.67	low_impact	0.84	0.68	neutral	0.46	neutral	4.31	24.00	deleterious	0.38	0.5	0.71	disease	0.7	disease	0.42	neutral	0.45	neutral	1	0.76	neutral	0.38	neutral	-3	neutral	0.69	deleterious	-1.28	low_impact	0.26	medium_impact	-0.32	medium_impact	0.36	0.8	29.07	74.35	0.23	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8022	8022	T	G	MI.6121	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	437	146	I	S	aTt/aGt	1.91	0	0	possibly_damaging	0.46	neutral	0.68	neutral	1.97	neutral	0.14	neutral	-1.59	neutral_impact	-0.2	0.68	neutral	0.61	neutral	2.31	18.20	deleterious	0.41	0.5	0.55	disease	0.66	disease	0.27	neutral	0.26	neutral	5	0.37	neutral	0.61	deleterious	-3	neutral	0.37	neutral	-0.66	medium_impact	0.39	medium_impact	-1.29	low_impact	0.33	0.8	29.07	74.35	0.25	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8022	8022	T	C	MI.6122	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	437	146	I	T	aTt/aCt	1.91	0	0	benign	0.2	neutral	0.68	neutral	2	neutral	0.58	neutral	-0.5	neutral_impact	-0.56	0.82	neutral	0.91	neutral	0.08	3.44	deleterious	0.55	0.6	0.26	neutral	0.34	neutral	0.23	neutral	0.44	neutral	1	0.21	neutral	0.74	deleterious	-6	neutral	0.21	neutral	-0.16	medium_impact	0.39	medium_impact	-1.63	low_impact	0.19	0.8	29.07	74.35	0.28	N	0.36	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8023	8023	T	A	MI.6123	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	438	146	I	M	atT/atA	0.06	0	0	possibly_damaging	0.66	neutral	0.38	neutral	1.97	neutral	-1.13	neutral	1.59	neutral_impact	-1.36	0.75	neutral	0.97	neutral	0.79	9.42	deleterious	0.74	0.8	0.34	neutral	0.08	neutral	0.11	neutral	0.26	neutral	5	0.69	neutral	0.36	neutral	-3	neutral	0.39	neutral	-0.99	medium_impact	0.09	medium_impact	-2.38	low_impact	0.65	0.8	29.07	74.35	0.52	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8023	8023	T	G	MI.6124	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	438	146	I	M	atT/atG	0.06	0	0	possibly_damaging	0.66	neutral	0.38	neutral	1.97	neutral	-1.13	neutral	1.59	neutral_impact	-1.36	0.75	neutral	0.97	neutral	0.46	7.14	deleterious	0.74	0.8	0.34	neutral	0.08	neutral	0.11	neutral	0.26	neutral	5	0.69	neutral	0.36	neutral	-3	neutral	0.39	neutral	-0.99	medium_impact	0.09	medium_impact	-2.38	low_impact	0.65	0.8	29.07	74.35	0.52	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8024	8024	G	C	MI.6125	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	439	147	E	Q	Gaa/Caa	-0.17	0	0	benign	0.08	neutral	0.61	neutral	1.95	neutral	-0.88	neutral	-1.92	neutral_impact	0.43	0.68	neutral	0.63	neutral	0.21	4.75	deleterious	0.4	0.5	0.47	neutral	0.29	neutral	0.18	neutral	0.45	neutral	1	0.3	neutral	0.77	deleterious	-6	neutral	0.22	neutral	0.27	medium_impact	0.31	medium_impact	-0.7	medium_impact	0.77	0.85	67.4	18.75	0.39	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8024	8024	G	A	MI.6126	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	439	147	E	K	Gaa/Aaa	-0.17	0	0	benign	0	neutral	0.92	neutral	2	neutral	-0.01	deleterious	-2.66	neutral_impact	-0.47	0.62	neutral	0.26	damaging	1.56	13.64	neutral	0.3	0.45	0.34	neutral	0.69	disease	0.24	neutral	0.24	neutral	5	0.06	neutral	0.96	deleterious	-6	neutral	0.21	neutral	2.08	high_impact	0.79	medium_impact	-1.55	low_impact	0.80	0.85	67.4	18.75	0.24	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8025	8025	A	T	MI.6127	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	440	147	E	V	gAa/gTa	1.91	0.97	0	benign	0.23	neutral	0.39	neutral	1.91	deleterious	-3.07	deleterious	-5.17	medium_impact	2.16	0.59	damaging	0.4	neutral	2.56	19.85	deleterious	0.23	0.45	0.56	disease	0.75	disease	0.48	neutral	0.51	disease	0	0.53	neutral	0.58	deleterious	-3	neutral	0.31	neutral	-0.23	medium_impact	0.1	medium_impact	0.92	medium_impact	0.71	0.85	67.4	18.75	0.41	N	0.82	disease_causing	0.88	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8025	8025	A	G	MI.6128	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	440	147	E	G	gAa/gGa	1.91	0.97	0	benign	0.17	neutral	0.43	neutral	2.17	neutral	1.5	deleterious	-3.57	neutral_impact	-1.38	0.66	neutral	0.75	neutral	1.41	12.83	neutral	0.26	0.45	0.28	neutral	0.54	disease	0.36	neutral	0.22	neutral	6	0.49	neutral	0.63	deleterious	-6	neutral	0.26	neutral	-0.08	medium_impact	0.14	medium_impact	-2.4	low_impact	0.46	0.8	67.4	18.75	0.37	N	0.64	disease_causing	0.78	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8025	8025	A	C	MI.6129	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	440	147	E	A	gAa/gCa	1.91	0.97	0	benign	0.11	neutral	0.81	neutral	1.95	neutral	-0.84	deleterious	-3.86	low_impact	1.61	0.61	neutral	0.52	neutral	1.92	15.73	deleterious	0.25	0.45	0.46	neutral	0.53	disease	0.4	neutral	0.46	neutral	1	0.09	neutral	0.85	deleterious	-6	neutral	0.23	neutral	0.13	medium_impact	0.55	medium_impact	0.4	medium_impact	0.64	0.8	67.4	18.75	0.38	N	0.66	disease_causing	0.75	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8815	8815	C	G	MI.613	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	289	97	Q	E	Caa/Gaa	-10.28	0	0	probably_damaging	0.94	neutral	0.09	neutral	4.35	neutral	-0.45	deleterious	-2.58	high_impact	3.98	0.6	neutral	0.14	damaging	3.05	22.40	deleterious	0.47	0.65	0.48	neutral	0.65	disease	0.7	disease	0.66	disease	3	0.98	neutral	0.08	neutral	2	deleterious	0.73	deleterious	-1.89	low_impact	-0.28	medium_impact	2.31	high_impact	0.55	0.9	48.23	8.28	0.34	N	0.94	polymorphism	0.79	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8026	8026	A	C	MI.6130	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	441	147	E	D	gaA/gaC	4.67	0.98	0	benign	0	neutral	0.62	neutral	2.09	neutral	0.97	neutral	-1.17	neutral_impact	0.1	0.76	neutral	0.73	neutral	0.59	8.11	deleterious	0.34	0.5	0.35	neutral	0.47	neutral	0.19	neutral	0.37	neutral	3	0.38	neutral	0.81	deleterious	-6	neutral	0.17	neutral	2.08	high_impact	0.32	medium_impact	-1.01	low_impact	0.75	0.85	67.4	18.75	0.47	N	0.81	disease_causing	0.59	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8026	8026	A	T	MI.6131	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	441	147	E	D	gaA/gaT	4.67	0.98	0	benign	0	neutral	0.62	neutral	2.09	neutral	0.97	neutral	-1.17	neutral_impact	0.1	0.76	neutral	0.73	neutral	0.75	9.14	deleterious	0.34	0.5	0.35	neutral	0.47	neutral	0.19	neutral	0.37	neutral	3	0.38	neutral	0.81	deleterious	-6	neutral	0.17	neutral	2.08	high_impact	0.32	medium_impact	-1.01	low_impact	0.75	0.85	67.4	18.75	0.48	N	0.81	disease_causing	0.59	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8027	8027	G	T	MI.6132	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	442	148	A	S	Gcc/Tcc	-0.4	0	0.01	probably_damaging	1	neutral	0.82	neutral	2.03	neutral	0.01	neutral	1.57	neutral_impact	-0.54	0.73	neutral	0.73	neutral	1.08	11.08	neutral	0.54	0.6	0.28	neutral	0.11	neutral	0.31	neutral	0.25	neutral	5	1	deleterious	0.41	neutral	-2	neutral	0.66	deleterious	-3.52	low_impact	0.57	medium_impact	-1.61	low_impact	0.84	0.9	30.4	66	0.28	N	0.44	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8027	8027	G	A	MI.6133	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	442	148	A	T	Gcc/Acc	-0.4	0	0.01	probably_damaging	1	neutral	0.61	neutral	2.05	neutral	0.95	neutral	0.15	neutral_impact	-1.17	0.95	neutral	0.78	neutral	2.81	21.40	deleterious	0.59	0.65	0.29	neutral	0.1	neutral	0.29	neutral	0.21	neutral	6	1	deleterious	0.31	neutral	-2	neutral	0.64	deleterious	-3.52	low_impact	0.31	medium_impact	-2.2	low_impact	0.61	0.8	30.4	66	0.31	N	0.09	polymorphism	1	0.00	rs1116904	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8027	8027	G	C	MI.6134	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	442	148	A	P	Gcc/Ccc	-0.4	0	0.01	probably_damaging	1	neutral	0.33	neutral	1.92	neutral	-2.15	neutral	-2.02	medium_impact	2	0.55	damaging	0.36	neutral	3.94	23.50	deleterious	0.28	0.45	0.61	disease	0.78	disease	0.6	disease	0.74	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	0.04	medium_impact	0.77	medium_impact	0.84	0.9	30.4	66	0.28	N	0.61	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8028	8028	C	A	MI.6135	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	443	148	A	D	gCc/gAc	0.06	0	0	probably_damaging	1	neutral	0.63	neutral	1.99	neutral	-0.55	neutral	-1.63	low_impact	1.09	0.57	damaging	0.43	neutral	4.76	24.70	deleterious	0.28	0.45	0.41	neutral	0.72	disease	0.67	disease	0.72	disease	4	1	deleterious	0.32	neutral	-2	neutral	0.76	deleterious	-3.52	low_impact	0.33	medium_impact	-0.08	medium_impact	0.76	0.85	30.4	66	0.26	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8028	8028	C	G	MI.6136	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	443	148	A	G	gCc/gGc	0.06	0	0	probably_damaging	1	neutral	0.39	neutral	1.93	neutral	-1.57	neutral	-1.56	low_impact	1.65	0.65	neutral	0.66	neutral	4.12	23.80	deleterious	0.51	0.6	0.53	disease	0.44	neutral	0.6	disease	0.52	disease	0	1	deleterious	0.2	neutral	-2	neutral	0.72	deleterious	-3.52	low_impact	0.1	medium_impact	0.44	medium_impact	0.84	0.9	30.4	66	0.35	N	0.36	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8028	8028	C	T	MI.6137	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	443	148	A	V	gCc/gTc	0.06	0	0	probably_damaging	1	neutral	0.31	neutral	1.99	neutral	-0.88	neutral	-1.76	neutral_impact	0.02	0.75	neutral	0.78	neutral	3.45	23.00	deleterious	0.53	0.6	0.28	neutral	0.5	disease	0.46	neutral	0.25	neutral	5	1	deleterious	0.16	neutral	-2	neutral	0.70	deleterious	-3.52	low_impact	0.01	medium_impact	-1.09	low_impact	0.68	0.85	30.4	66	0.35	N	0.21	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8030	8030	C	G	MI.6138	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	445	149	P	A	Ccc/Gcc	-10.55	0	0	benign	0.33	neutral	0.76	neutral	2.02	neutral	-1.84	deleterious	-5.46	low_impact	1.88	0.59	damaging	0.64	neutral	1.47	13.17	neutral	0.44	0.55	0.63	disease	0.4	neutral	0.37	neutral	0.62	disease	2	0.22	neutral	0.72	deleterious	-6	neutral	0.43	neutral	-0.43	medium_impact	0.48	medium_impact	0.66	medium_impact	0.54	0.8	29.96	51.16	0.3	N	0.61	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8030	8030	C	A	MI.6139	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	445	149	P	T	Ccc/Acc	-10.55	0	0	possibly_damaging	0.57	neutral	0.58	neutral	2	neutral	-1.33	deleterious	-5.09	low_impact	1.4	0.74	neutral	0.97	neutral	2.28	18.06	deleterious	0.39	0.5	0.44	neutral	0.43	neutral	0.36	neutral	0.43	neutral	1	0.52	neutral	0.51	deleterious	-3	neutral	0.51	deleterious	-0.84	medium_impact	0.28	medium_impact	0.21	medium_impact	0.51	0.8	29.96	51.16	0.38	N	0.12	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8816	8816	A	G	MI.614	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	290	97	Q	R	cAa/cGa	7.3	1	0	probably_damaging	0.97	deleterious	0.02	neutral	4.3	neutral	-1.27	deleterious	-3.47	high_impact	3.98	0.63	neutral	0.16	damaging	3.47	23.00	deleterious	0.48	0.65	0.59	disease	0.79	disease	0.74	disease	0.71	disease	4	1	deleterious	0.03	neutral	6	deleterious	0.81	deleterious	-2.19	low_impact	-0.66	medium_impact	2.31	high_impact	0.54	0.9	48.23	8.28	0.51	P	0.91	disease_causing	1	0.11	rs1057520102	Uncertain_significance	not_provided	363859	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8030	8030	C	T	MI.6140	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	445	149	P	S	Ccc/Tcc	-10.55	0	0	benign	0.07	neutral	0.74	neutral	2.04	neutral	-1.67	deleterious	-5.38	low_impact	1.69	0.69	neutral	0.76	neutral	0.97	10.48	neutral	0.57	0.65	0.62	disease	0.53	disease	0.25	neutral	0.28	neutral	4	0.17	neutral	0.84	deleterious	-6	neutral	0.25	neutral	0.33	medium_impact	0.46	medium_impact	0.48	medium_impact	0.23	0.8	29.96	51.16	0.28	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8031	8031	C	A	MI.6141	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	446	149	P	H	cCc/cAc	1.68	0.79	0	probably_damaging	0.95	neutral	0.13	neutral	1.99	neutral	-1.75	deleterious	-6.7	low_impact	1.12	0.55	damaging	0.53	neutral	4.06	23.70	deleterious	0.37	0.5	0.57	disease	0.57	disease	0.34	neutral	0.28	neutral	4	0.98	neutral	0.09	neutral	-2	neutral	0.73	deleterious	-1.91	low_impact	-0.25	medium_impact	-0.06	medium_impact	0.38	0.8	29.96	51.16	0.36	N	0.81	disease_causing	0.89	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8031	8031	C	T	MI.6142	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	446	149	P	L	cCc/cTc	1.68	0.79	0	possibly_damaging	0.76	neutral	0.34	neutral	1.96	neutral	-2.96	deleterious	-7.17	low_impact	1.5	0.64	neutral	0.54	neutral	4.27	23.90	deleterious	0.42	0.55	0.51	disease	0.52	disease	0.35	neutral	0.29	neutral	4	0.8	neutral	0.29	neutral	-3	neutral	0.61	deleterious	-1.19	low_impact	0.05	medium_impact	0.3	medium_impact	0.62	0.8	29.96	51.16	0.38	N	0.91	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8031	8031	C	G	MI.6143	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	446	149	P	R	cCc/cGc	1.68	0.79	0	possibly_damaging	0.88	neutral	0.53	neutral	2.01	neutral	-1.44	deleterious	-6.63	low_impact	1.74	0.45	damaging	0.34	neutral	3.56	23.10	deleterious	0.37	0.5	0.5	neutral	0.74	disease	0.47	neutral	0.48	neutral	0	0.86	neutral	0.33	neutral	-3	neutral	0.71	deleterious	-1.53	low_impact	0.23	medium_impact	0.53	medium_impact	0.37	0.8	29.96	51.16	0.34	N	0.90	disease_causing	0.94	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8033	8033	A	C	MI.6144	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	448	150	I	L	Att/Ctt	-11.47	0	0	benign	0	neutral	0.36	neutral	1.83	neutral	-2.19	neutral	-1.66	medium_impact	2.49	0.56	damaging	0.39	neutral	2.00	16.23	deleterious	0.33	0.5	0.64	disease	0.56	disease	0.55	disease	0.49	neutral	0	0.64	neutral	0.68	deleterious	-3	neutral	0.25	neutral	2.08	high_impact	0.07	medium_impact	1.23	medium_impact	0.73	0.85	27.75	40.03	0.36	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8033	8033	A	G	MI.6145	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	448	150	I	V	Att/Gtt	-11.47	0	0	benign	0	neutral	0.33	neutral	2.11	neutral	1.58	neutral	-0.37	neutral_impact	0.77	0.85	neutral	0.92	neutral	-0.44	0.32	neutral	0.46	0.55	0.28	neutral	0.21	neutral	0.35	neutral	0.35	neutral	3	0.67	neutral	0.67	deleterious	-6	neutral	0.16	neutral	2.08	high_impact	0.04	medium_impact	-0.38	medium_impact	0.56	0.8	27.75	40.03	0.42	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8033	8033	A	T	MI.6146	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	448	150	I	F	Att/Ttt	-11.47	0	0	benign	0.08	neutral	0.06	neutral	1.69	deleterious	-3.82	deleterious	-3.49	high_impact	3.62	0.48	damaging	0.28	neutral	2.42	18.92	deleterious	0.24	0.45	0.91	disease	0.74	disease	0.67	disease	0.68	disease	4	0.93	neutral	0.49	deleterious	-2	neutral	0.44	deleterious	0.27	medium_impact	-0.46	medium_impact	2.29	high_impact	0.68	0.85	27.75	40.03	0.32	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8034	8034	T	G	MI.6147	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	449	150	I	S	aTt/aGt	1.21	0.38	0	possibly_damaging	0.68	neutral	0.74	neutral	1.69	deleterious	-4.82	deleterious	-4.56	medium_impact	2.89	0.55	damaging	0.36	neutral	4.37	24.10	deleterious	0.16	0.45	0.93	disease	0.84	disease	0.6	disease	0.69	disease	4	0.61	neutral	0.53	deleterious	0	NA	0.54	deleterious	-1.03	low_impact	0.46	medium_impact	1.6	medium_impact	0.48	0.8	27.75	40.03	0.29	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8034	8034	T	A	MI.6148	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	449	150	I	N	aTt/aAt	1.21	0.38	0	possibly_damaging	0.88	neutral	0.49	neutral	1.67	deleterious	-6.02	deleterious	-5.58	medium_impact	3.48	0.54	damaging	0.28	neutral	4.48	24.20	deleterious	0.12	0.4	0.96	disease	0.79	disease	0.68	disease	0.72	disease	4	0.86	neutral	0.31	neutral	0	NA	0.85	deleterious	-1.53	low_impact	0.2	medium_impact	2.16	high_impact	0.56	0.8	27.75	40.03	0.31	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8034	8034	T	C	MI.6149	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	449	150	I	T	aTt/aCt	1.21	0.38	0	benign	0.32	neutral	0.57	neutral	1.72	neutral	-2.89	deleterious	-3.11	low_impact	1.42	0.69	neutral	0.77	neutral	2.15	17.15	deleterious	0.29	0.45	0.6	disease	0.54	disease	0.45	neutral	0.23	neutral	5	0.34	neutral	0.63	deleterious	-6	neutral	0.32	neutral	-0.42	medium_impact	0.27	medium_impact	0.23	medium_impact	0.50	0.8	27.75	40.03	0.27	N	0.87	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8816	8816	A	T	MI.615	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	290	97	Q	L	cAa/cTa	7.3	1	0	probably_damaging	0.97	deleterious	0.04	neutral	4.27	neutral	-2.14	deleterious	-6.09	medium_impact	2.7	0.61	neutral	0.12	damaging	3.80	23.40	deleterious	0.32	0.65	0.71	disease	0.77	disease	0.66	disease	0.59	disease	2	1	deleterious	0.04	neutral	5	deleterious	0.78	deleterious	-2.19	low_impact	-0.49	medium_impact	1.22	medium_impact	0.36	0.9	48.23	8.28	0.48	P	0.99	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8035	8035	T	A	MI.6150	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	450	150	I	M	atT/atA	4.67	0.8	0	benign	0.11	neutral	0.11	neutral	1.71	deleterious	-4.33	neutral	-2.31	medium_impact	2.73	0.59	damaging	0.39	neutral	3.41	23.00	deleterious	0.32	0.5	0.89	disease	0.57	disease	0.56	disease	0.63	disease	3	0.88	neutral	0.5	deleterious	-3	neutral	0.32	neutral	0.13	medium_impact	-0.3	medium_impact	1.45	medium_impact	0.72	0.85	27.75	40.03	0.44	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8035	8035	T	G	MI.6151	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	450	150	I	M	atT/atG	4.67	0.8	0	benign	0.11	neutral	0.11	neutral	1.71	deleterious	-4.33	neutral	-2.31	medium_impact	2.73	0.59	damaging	0.39	neutral	3.20	22.70	deleterious	0.32	0.5	0.89	disease	0.57	disease	0.56	disease	0.63	disease	3	0.88	neutral	0.5	deleterious	-3	neutral	0.32	neutral	0.13	medium_impact	-0.3	medium_impact	1.45	medium_impact	0.72	0.85	27.75	40.03	0.45	N	0.72	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8036	8036	C	A	MI.6152	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	451	151	R	S	Cgt/Agt	-11.47	0	0	probably_damaging	1	neutral	0.82	neutral	1.8	neutral	-2.06	deleterious	-5.89	medium_impact	3.03	0.11	damaging	0.01	damaging	4.67	24.50	deleterious	0.23	0.45	0.58	disease	0.83	disease	0.74	disease	0.72	disease	4	1	deleterious	0.41	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	0.57	medium_impact	1.74	medium_impact	0.43	0.8	68.72	19.92	0.64	P	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8036	8036	C	G	MI.6153	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	451	151	R	G	Cgt/Ggt	-11.47	0	0	probably_damaging	1	neutral	0.49	neutral	1.76	deleterious	-3.37	deleterious	-6.87	high_impact	3.63	0.12	damaging	0.02	damaging	4.29	24.00	deleterious	0.25	0.45	0.51	disease	0.77	disease	0.76	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	0.2	medium_impact	2.3	high_impact	0.37	0.8	68.72	19.92	0.59	P	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8036	8036	C	T	MI.6154	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	451	151	R	C	Cgt/Tgt	-11.47	0	0	probably_damaging	1	neutral	0.13	neutral	1.74	deleterious	-5.77	deleterious	-7.86	high_impact	3.98	0.13	damaging	0	damaging	5.09	25.30	deleterious	0.3	0.45	0.93	disease	0.81	disease	0.79	disease	0.73	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.25	medium_impact	2.63	high_impact	0.78	0.85	68.72	19.92	0.66	P	1.00	disease_causing	0.57	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8037	8037	G	A	MI.6155	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	452	151	R	H	cGt/cAt	3.52	0.99	0	probably_damaging	1	neutral	0.36	neutral	1.77	neutral	-2.89	deleterious	-4.91	high_impact	3.56	0.1	damaging	0	damaging	4.45	24.20	deleterious	0.41	0.5	0.79	disease	0.8	disease	0.75	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.07	medium_impact	2.23	high_impact	0.85	0.9	68.72	19.92	0.9	P	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8037	8037	G	T	MI.6156	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	452	151	R	L	cGt/cTt	3.52	0.99	0	probably_damaging	1	neutral	0.6	neutral	1.84	neutral	-2.16	deleterious	-6.88	medium_impact	2.94	0.11	damaging	0.01	damaging	4.42	24.20	deleterious	0.28	0.45	0.41	neutral	0.87	disease	0.75	disease	0.71	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	0.3	medium_impact	1.65	medium_impact	0.26	0.8	68.72	19.92	0.85	P	1.00	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8037	8037	G	C	MI.6157	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	452	151	R	P	cGt/cCt	3.52	0.99	0	probably_damaging	1	neutral	0.34	neutral	1.76	deleterious	-4.05	deleterious	-6.88	high_impact	4.18	0.14	damaging	0.02	damaging	4.29	24.00	deleterious	0.16	0.45	0.82	disease	0.85	disease	0.75	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.05	medium_impact	2.81	high_impact	0.37	0.8	68.72	19.92	0.83	P	1.00	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8039	8039	A	T	MI.6158	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	454	152	M	L	Ata/Tta	-6.63	0	0	probably_damaging	0.91	neutral	0.83	neutral	2.2	neutral	2.2	neutral	-1.18	neutral_impact	-0.36	0.65	neutral	0.22	damaging	2.36	18.56	deleterious	0.41	0.5	0.45	neutral	0.54	disease	0.3	neutral	0.21	neutral	6	0.89	neutral	0.46	neutral	-2	neutral	0.60	deleterious	-1.66	low_impact	0.59	medium_impact	-1.44	low_impact	0.74	0.85	69.6	17.45	0.26	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8039	8039	A	G	MI.6159	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	454	152	M	V	Ata/Gta	-6.63	0	0	probably_damaging	0.94	neutral	1	neutral	2.21	neutral	1.61	neutral	-0.77	neutral_impact	0.32	0.72	neutral	0.89	neutral	0.19	4.53	deleterious	0.44	0.55	0.26	neutral	0.39	neutral	0.3	neutral	0.44	neutral	1	0.94	neutral	0.53	deleterious	-2	neutral	0.65	deleterious	-1.83	low_impact	1.86	high_impact	-0.81	medium_impact	0.77	0.85	69.6	17.45	0.3	N	0.89	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8816	8816	A	C	MI.616	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	290	97	Q	P	cAa/cCa	7.3	1	0	probably_damaging	0.98	deleterious	0.01	neutral	4.26	neutral	-2.69	deleterious	-4.92	high_impact	3.98	0.53	damaging	0.2	damaging	3.24	22.80	deleterious	0.18	0.65	0.77	disease	0.83	disease	0.77	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-2.36	low_impact	-0.84	medium_impact	2.31	high_impact	0.56	0.9	48.23	8.28	0.56	P	0.98	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8039	8039	A	C	MI.6160	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	454	152	M	L	Ata/Cta	-6.63	0	0	probably_damaging	0.91	neutral	0.83	neutral	2.2	neutral	2.2	neutral	-1.18	neutral_impact	-0.36	0.65	neutral	0.22	damaging	2.25	17.86	deleterious	0.41	0.5	0.45	neutral	0.54	disease	0.3	neutral	0.21	neutral	6	0.89	neutral	0.46	neutral	-2	neutral	0.60	deleterious	-1.66	low_impact	0.59	medium_impact	-1.44	low_impact	0.74	0.85	69.6	17.45	0.26	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8040	8040	T	A	MI.6161	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	455	152	M	K	aTa/aAa	0.06	0	0	probably_damaging	0.97	neutral	0.31	neutral	1.93	neutral	-2.06	deleterious	-4.31	medium_impact	3.32	0.49	damaging	0.1	damaging	4.02	23.60	deleterious	0.09	0.4	0.75	disease	0.83	disease	0.67	disease	0.72	disease	4	0.98	neutral	0.17	neutral	1	deleterious	0.84	deleterious	-2.13	low_impact	0.01	medium_impact	2.01	high_impact	0.53	0.8	69.6	17.45	0.3	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8040	8040	T	C	MI.6162	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	455	152	M	T	aTa/aCa	0.06	0	0	probably_damaging	0.99	neutral	0.57	neutral	1.98	neutral	-0.27	deleterious	-3.12	medium_impact	2.63	0.66	neutral	0.32	neutral	1.97	16.05	deleterious	0.28	0.45	0.56	disease	0.63	disease	0.51	disease	0.19	neutral	6	0.99	deleterious	0.29	neutral	1	deleterious	0.78	deleterious	-2.58	low_impact	0.27	medium_impact	1.36	medium_impact	0.57	0.8	69.6	17.45	0.22	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8041	8041	A	T	MI.6163	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	456	152	M	I	atA/atT	5.83	0.88	0	probably_damaging	0.96	neutral	0.95	neutral	2.14	neutral	1.39	neutral	-0.92	neutral_impact	0.55	0.73	neutral	0.56	neutral	1.92	15.74	deleterious	0.41	0.5	0.34	neutral	0.28	neutral	0.28	neutral	0.45	neutral	1	0.96	neutral	0.5	deleterious	-2	neutral	0.66	deleterious	-2.01	low_impact	0.91	medium_impact	-0.59	medium_impact	0.85	0.9	69.6	17.45	0.43	N	0.78	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8041	8041	A	C	MI.6164	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	456	152	M	I	atA/atC	5.83	0.88	0	probably_damaging	0.96	neutral	0.95	neutral	2.14	neutral	1.39	neutral	-0.92	neutral_impact	0.55	0.73	neutral	0.56	neutral	1.86	15.33	deleterious	0.41	0.5	0.34	neutral	0.28	neutral	0.28	neutral	0.45	neutral	1	0.96	neutral	0.5	deleterious	-2	neutral	0.66	deleterious	-2.01	low_impact	0.91	medium_impact	-0.59	medium_impact	0.85	0.9	69.6	17.45	0.43	N	0.78	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8042	8042	A	C	MI.6165	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	457	153	M	L	Ata/Cta	-2.01	0	0	possibly_damaging	0.9	neutral	0.74	neutral	2.27	neutral	2.79	neutral	1.7	neutral_impact	-1.69	0.78	neutral	0.97	neutral	0.75	9.12	deleterious	0.52	0.6	0.39	neutral	0.18	neutral	0.33	neutral	0.26	neutral	5	0.88	neutral	0.42	neutral	-3	neutral	0.55	deleterious	-1.61	low_impact	0.46	medium_impact	-2.69	low_impact	0.49	0.8	28.63	71.78	0.27	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8042	8042	A	T	MI.6166	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	457	153	M	L	Ata/Tta	-2.01	0	0	possibly_damaging	0.9	neutral	0.74	neutral	2.27	neutral	2.79	neutral	1.7	neutral_impact	-1.69	0.78	neutral	0.97	neutral	0.82	9.56	deleterious	0.52	0.6	0.39	neutral	0.18	neutral	0.33	neutral	0.26	neutral	5	0.88	neutral	0.42	neutral	-3	neutral	0.55	deleterious	-1.61	low_impact	0.46	medium_impact	-2.69	low_impact	0.49	0.8	28.63	71.78	0.27	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8042	8042	A	G	MI.6167	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	457	153	M	V	Ata/Gta	-2.01	0	0	probably_damaging	0.94	neutral	0.5	neutral	2.07	neutral	1.25	neutral	-0.82	neutral_impact	0.02	0.62	neutral	0.29	neutral	2.94	22.00	deleterious	0.64	0.7	0.36	neutral	0.55	disease	0.43	neutral	0.17	neutral	7	0.93	neutral	0.28	neutral	-2	neutral	0.65	deleterious	-1.83	low_impact	0.21	medium_impact	-1.09	low_impact	0.52	0.8	28.63	71.78	0.3	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8043	8043	T	C	MI.6168	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	458	153	M	T	aTa/aCa	-2.24	0	0	probably_damaging	0.97	neutral	0.6	neutral	2.02	neutral	0.46	deleterious	-2.96	low_impact	1.19	0.6	neutral	0.3	neutral	3.14	22.60	deleterious	0.51	0.6	0.37	neutral	0.49	neutral	0.64	disease	0.65	disease	3	0.97	neutral	0.32	neutral	-2	neutral	0.73	deleterious	-2.13	low_impact	0.3	medium_impact	0.01	medium_impact	0.28	0.8	28.63	71.78	0.21	N	0.72	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8043	8043	T	A	MI.6169	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	458	153	M	K	aTa/aAa	-2.24	0	0	probably_damaging	0.97	neutral	0.85	neutral	2.02	neutral	0.48	deleterious	-4	low_impact	1.32	0.5	damaging	0.23	damaging	4.20	23.90	deleterious	0.3	0.45	0.47	neutral	0.71	disease	0.7	disease	0.7	disease	4	0.97	neutral	0.44	neutral	-2	neutral	0.75	deleterious	-2.13	low_impact	0.62	medium_impact	0.13	medium_impact	0.58	0.8	28.63	71.78	0.27	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8817	8817	A	C	MI.617	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	291	97	Q	H	caA/caC	8.69	1	0	probably_damaging	1	neutral	1	neutral	4.4	neutral	0.1	deleterious	-4.34	low_impact	1.16	0.65	neutral	0.18	damaging	3.43	23.00	deleterious	0.55	0.65	0.26	neutral	0.25	neutral	0.54	disease	0.4	neutral	2	0.99	deleterious	0.5	deleterious	-2	neutral	0.72	deleterious	-3.6	low_impact	1.98	high_impact	-0.1	medium_impact	0.72	0.9	48.23	8.28	0.44	N	0.97	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8044	8044	A	C	MI.6170	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	459	153	M	I	atA/atC	7.44	0.96	0	probably_damaging	0.96	neutral	0.42	neutral	2.13	neutral	1.85	neutral	0.12	neutral_impact	-0.38	0.77	neutral	0.68	neutral	2.38	18.69	deleterious	0.58	0.65	0.35	neutral	0.34	neutral	0.39	neutral	0.43	neutral	1	0.95	neutral	0.23	neutral	-2	neutral	0.66	deleterious	-2.01	low_impact	0.13	medium_impact	-1.46	low_impact	0.61	0.8	28.63	71.78	0.51	P	0.29	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8044	8044	A	T	MI.6171	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	459	153	M	I	atA/atT	7.44	0.96	0	probably_damaging	0.96	neutral	0.42	neutral	2.13	neutral	1.85	neutral	0.12	neutral_impact	-0.38	0.77	neutral	0.68	neutral	2.44	19.07	deleterious	0.58	0.65	0.35	neutral	0.34	neutral	0.39	neutral	0.43	neutral	1	0.95	neutral	0.23	neutral	-2	neutral	0.66	deleterious	-2.01	low_impact	0.13	medium_impact	-1.46	low_impact	0.61	0.8	28.63	71.78	0.52	P	0.29	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8045	8045	A	T	MI.6172	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	460	154	I	F	Att/Ttt	-0.17	0	0	probably_damaging	0.99	neutral	0.49	neutral	1.64	deleterious	-3.54	deleterious	-3.92	medium_impact	2.58	0.51	damaging	0.32	neutral	3.85	23.40	deleterious	0.19	0.45	0.71	disease	0.7	disease	0.69	disease	0.69	disease	4	0.99	deleterious	0.25	neutral	1	deleterious	0.81	deleterious	-2.58	low_impact	0.2	medium_impact	1.31	medium_impact	0.75	0.85	65.2	18.48	0.31	N	0.87	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8045	8045	A	G	MI.6173	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	460	154	I	V	Att/Gtt	-0.17	0	0	probably_damaging	0.97	neutral	1	neutral	2.08	neutral	0.29	neutral	-0.36	neutral_impact	0.27	0.7	neutral	0.88	neutral	0.64	8.45	deleterious	0.47	0.55	0.26	neutral	0.05	neutral	0.28	neutral	0.16	neutral	7	0.97	neutral	0.52	deleterious	-2	neutral	0.62	deleterious	-2.13	low_impact	1.86	high_impact	-0.85	medium_impact	0.71	0.85	65.2	18.48	0.33	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8045	8045	A	C	MI.6174	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	460	154	I	L	Att/Ctt	-0.17	0	0	probably_damaging	0.97	neutral	0.48	neutral	1.85	neutral	-0.74	neutral	-1.96	low_impact	1.53	0.59	damaging	0.36	neutral	3.91	23.50	deleterious	0.29	0.45	0.29	neutral	0.52	disease	0.61	disease	0.65	disease	3	0.96	neutral	0.26	neutral	-2	neutral	0.66	deleterious	-2.13	low_impact	0.19	medium_impact	0.33	medium_impact	0.79	0.85	65.2	18.48	0.31	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8046	8046	T	A	MI.6175	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	461	154	I	N	aTt/aAt	0.06	0.01	0	probably_damaging	1	neutral	0.22	neutral	1.62	deleterious	-4.84	deleterious	-6.54	high_impact	3.56	0.53	damaging	0.32	neutral	4.65	24.50	deleterious	0.15	0.4	0.85	disease	0.78	disease	0.69	disease	0.67	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.1	medium_impact	2.23	high_impact	0.62	0.8	65.2	18.48	0.31	N	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8046	8046	T	G	MI.6176	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	461	154	I	S	aTt/aGt	0.06	0.01	0	probably_damaging	0.99	neutral	0.37	neutral	1.64	deleterious	-3.76	deleterious	-5.56	medium_impact	2.62	0.54	damaging	0.34	neutral	4.41	24.10	deleterious	0.18	0.45	0.72	disease	0.77	disease	0.66	disease	0.7	disease	4	0.99	deleterious	0.19	neutral	1	deleterious	0.83	deleterious	-2.58	low_impact	0.08	medium_impact	1.35	medium_impact	0.56	0.8	65.2	18.48	0.26	N	0.89	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8046	8046	T	C	MI.6177	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	461	154	I	T	aTt/aCt	0.06	0.01	0	probably_damaging	0.99	neutral	0.55	neutral	1.69	neutral	-2.37	deleterious	-4.26	low_impact	1.3	0.66	neutral	0.35	neutral	3.58	23.20	deleterious	0.22	0.45	0.52	disease	0.6	disease	0.58	disease	0.58	disease	2	0.99	deleterious	0.28	neutral	-2	neutral	0.77	deleterious	-2.58	low_impact	0.25	medium_impact	0.11	medium_impact	0.54	0.8	65.2	18.48	0.21	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8047	8047	T	A	MI.6178	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	462	154	I	M	atT/atA	7.44	0.96	0	probably_damaging	1	neutral	0.14	neutral	1.65	deleterious	-3.34	deleterious	-2.63	medium_impact	2.41	0.59	damaging	0.35	neutral	3.83	23.40	deleterious	0.27	0.45	0.29	neutral	0.51	disease	0.58	disease	0.63	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.70	deleterious	-3.52	low_impact	-0.23	medium_impact	1.15	medium_impact	0.82	0.85	65.2	18.48	0.53	P	0.69	polymorphism	1	0.04	rs386829022	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8047	8047	T	G	MI.6179	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	462	154	I	M	atT/atG	7.44	0.96	0	probably_damaging	1	neutral	0.14	neutral	1.65	deleterious	-3.34	deleterious	-2.63	medium_impact	2.41	0.59	damaging	0.35	neutral	3.53	23.10	deleterious	0.27	0.45	0.29	neutral	0.51	disease	0.58	disease	0.63	disease	3	1	deleterious	0.07	neutral	1	deleterious	0.70	deleterious	-3.52	low_impact	-0.23	medium_impact	1.15	medium_impact	0.82	0.85	65.2	18.48	0.52	P	0.69	polymorphism	1	0.04	rs386829022	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8817	8817	A	T	MI.618	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	291	97	Q	H	caA/caT	8.69	1	0	probably_damaging	1	neutral	1	neutral	4.4	neutral	0.1	deleterious	-4.34	low_impact	1.16	0.65	neutral	0.18	damaging	3.57	23.10	deleterious	0.55	0.65	0.26	neutral	0.25	neutral	0.54	disease	0.4	neutral	2	0.99	deleterious	0.5	deleterious	-2	neutral	0.72	deleterious	-3.6	low_impact	1.98	high_impact	-0.1	medium_impact	0.72	0.9	48.23	8.28	0.44	N	0.97	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8048	8048	A	C	MI.6180	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	463	155	T	P	Aca/Cca	-6.4	0	0	probably_damaging	1	neutral	0.31	neutral	1.4	deleterious	-4.74	deleterious	-3.77	high_impact	3.75	0.49	damaging	0.16	damaging	3.61	23.20	deleterious	0.17	0.45	0.83	disease	0.86	disease	0.76	disease	0.68	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.01	medium_impact	2.41	high_impact	0.54	0.8	27.75	60.5	0.39	N	0.61	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8048	8048	A	T	MI.6181	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	463	155	T	S	Aca/Tca	-6.4	0	0	probably_damaging	0.99	neutral	1	neutral	1.59	neutral	-1.72	neutral	-0.21	neutral_impact	0.32	0.75	neutral	0.97	neutral	0.77	9.25	deleterious	0.41	0.5	0.39	neutral	0.23	neutral	0.46	neutral	0.38	neutral	2	0.99	deleterious	0.51	deleterious	-2	neutral	0.70	deleterious	-2.58	low_impact	1.86	high_impact	-0.81	medium_impact	0.70	0.85	27.75	60.5	0.29	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8048	8048	A	G	MI.6182	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	463	155	T	A	Aca/Gca	-6.4	0	0	probably_damaging	0.99	neutral	0.93	neutral	1.54	neutral	-2.18	neutral	-2.26	medium_impact	3.12	0.57	damaging	0.26	damaging	3.60	23.20	deleterious	0.56	0.6	0.61	disease	0.66	disease	0.7	disease	0.66	disease	3	0.99	deleterious	0.47	deleterious	1	deleterious	0.76	deleterious	-2.58	low_impact	0.83	medium_impact	1.82	medium_impact	0.59	0.8	27.75	60.5	0.2	N	0.14	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8049	8049	C	T	MI.6183	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	464	155	T	M	aCa/aTa	1.21	0.86	0	probably_damaging	1	neutral	0.23	neutral	1.39	deleterious	-5.37	deleterious	-3.77	high_impact	4.09	0.55	damaging	0.2	damaging	4.12	23.80	deleterious	0.4	0.5	0.84	disease	0.77	disease	0.78	disease	0.7	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	-0.09	medium_impact	2.73	high_impact	0.67	0.85	27.75	60.5	0.47	N	0.68	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8049	8049	C	A	MI.6184	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	464	155	T	K	aCa/aAa	1.21	0.86	0	probably_damaging	1	neutral	0.8	neutral	1.43	deleterious	-3.83	deleterious	-3.24	medium_impact	2.85	0.5	damaging	0.18	damaging	4.55	24.40	deleterious	0.24	0.45	0.32	neutral	0.86	disease	0.8	disease	0.7	disease	4	1	deleterious	0.4	neutral	1	deleterious	0.76	deleterious	-3.52	low_impact	0.54	medium_impact	1.57	medium_impact	0.72	0.85	27.75	60.5	0.42	N	0.50	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8051	8051	T	C	MI.6185	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	466	156	S	P	Tca/Cca	-3.17	0	0	probably_damaging	1	neutral	0.32	neutral	1.39	deleterious	-5.46	deleterious	-2.87	high_impact	3.77	0.35	damaging	0.13	damaging	4.13	23.80	deleterious	0.18	0.45	0.83	disease	0.91	disease	0.71	disease	0.69	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	0.02	medium_impact	2.43	high_impact	0.73	0.85	68.72	19.53	0.47	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8051	8051	T	A	MI.6186	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	466	156	S	T	Tca/Aca	-3.17	0	0	probably_damaging	0.99	neutral	0.61	neutral	1.47	deleterious	-3.66	neutral	-1.58	medium_impact	3.35	0.51	damaging	0.18	damaging	3.94	23.50	deleterious	0.23	0.45	0.79	disease	0.63	disease	0.72	disease	0.69	disease	4	0.98	deleterious	0.31	neutral	1	deleterious	0.83	deleterious	-2.58	low_impact	0.31	medium_impact	2.04	high_impact	0.80	0.85	68.72	19.53	0.29	N	0.53	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8051	8051	T	G	MI.6187	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	466	156	S	A	Tca/Gca	-3.17	0	0	probably_damaging	0.99	neutral	1	neutral	1.69	neutral	-1.36	neutral	1.14	neutral_impact	0.67	0.71	neutral	0.7	neutral	1.14	11.42	neutral	0.27	0.45	0.44	neutral	0.12	neutral	0.33	neutral	0.24	neutral	5	0.99	deleterious	0.51	deleterious	-2	neutral	0.71	deleterious	-2.58	low_impact	1.86	high_impact	-0.48	medium_impact	0.84	0.9	68.72	19.53	0.27	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8052	8052	C	G	MI.6188	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	467	156	S	W	tCa/tGa	4.21	1	0	probably_damaging	1	neutral	0.18	neutral	1.38	deleterious	-8.67	deleterious	-4.83	high_impact	4.32	0.44	damaging	0.2	damaging	4.41	24.10	deleterious	0.1	0.4	0.62	disease	0.92	disease	0.75	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.16	medium_impact	2.95	high_impact	0.36	0.8	68.72	19.53	0.58	P	1.00	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8052	8052	C	T	MI.6189	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	467	156	S	L	tCa/tTa	4.21	1	0	probably_damaging	1	neutral	0.74	neutral	1.42	deleterious	-5.36	deleterious	-3.17	high_impact	4.32	0.46	damaging	0.17	damaging	4.70	24.60	deleterious	0.12	0.4	0.56	disease	0.82	disease	0.69	disease	0.72	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.46	medium_impact	2.95	high_impact	0.87	0.9	68.72	19.53	0.6	P	0.99	disease_causing	0.96	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8818	8818	C	A	MI.619	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	292	98	L	M	Cta/Ata	1.29	0.85	0.01	probably_damaging	1	neutral	0.1	neutral	4.16	neutral	-2.64	neutral	-1.72	medium_impact	2.65	0.53	damaging	0.16	damaging	3.86	23.50	deleterious	0.39	0.65	0.78	disease	0.26	neutral	0.47	neutral	0.54	disease	1	1	deleterious	0.05	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	-0.25	medium_impact	1.17	medium_impact	0.81	0.9	48.67	8.57	0.42	N	0.96	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8054	8054	C	A	MI.6190	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	469	157	Q	K	Caa/Aaa	-14.24	0	0	probably_damaging	0.99	neutral	0.91	neutral	2.02	neutral	0.24	neutral	-1.15	neutral_impact	-0.34	0.57	damaging	0.25	damaging	4.11	23.70	deleterious	0.5	0.6	0.24	neutral	0.6	disease	0.37	neutral	0.41	neutral	2	0.99	deleterious	0.46	neutral	-2	neutral	0.69	deleterious	-2.58	low_impact	0.76	medium_impact	-1.42	low_impact	0.64	0.8	29.07	72.35	0.24	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8054	8054	C	G	MI.6191	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	469	157	Q	E	Caa/Gaa	-14.24	0	0	probably_damaging	0.97	neutral	1	neutral	2.08	neutral	0.15	neutral	2.3	neutral_impact	-1.68	0.74	neutral	0.96	neutral	0.51	7.50	deleterious	0.47	0.55	0.23	neutral	0.26	neutral	0.17	neutral	0.41	neutral	2	0.97	neutral	0.52	deleterious	-2	neutral	0.66	deleterious	-2.13	low_impact	1.86	high_impact	-2.68	low_impact	0.81	0.85	29.07	72.35	0.33	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8055	8055	A	T	MI.6192	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	470	157	Q	L	cAa/cTa	4.21	1	0	probably_damaging	0.99	neutral	0.7	neutral	1.98	neutral	-1.37	deleterious	-4.75	neutral_impact	-0.62	0.66	neutral	0.29	neutral	3.75	23.30	deleterious	0.34	0.5	0.59	disease	0.57	disease	0.36	neutral	0.35	neutral	3	0.99	deleterious	0.36	neutral	-2	neutral	0.75	deleterious	-2.58	low_impact	0.41	medium_impact	-1.69	low_impact	0.32	0.8	29.07	72.35	0.36	N	0.83	disease_causing	0.56	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8055	8055	A	C	MI.6193	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	470	157	Q	P	cAa/cCa	4.21	1	0	probably_damaging	0.99	neutral	0.35	neutral	1.92	neutral	-1.77	deleterious	-2.75	neutral_impact	0.3	0.51	damaging	0.2	damaging	3.32	22.90	deleterious	0.15	0.4	0.66	disease	0.82	disease	0.39	neutral	0.59	disease	2	0.99	deleterious	0.18	neutral	-2	neutral	0.84	deleterious	-2.58	low_impact	0.06	medium_impact	-0.82	medium_impact	0.41	0.8	29.07	72.35	0.44	N	0.75	disease_causing	0.62	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8055	8055	A	G	MI.6194	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	470	157	Q	R	cAa/cGa	4.21	1	0	probably_damaging	0.99	neutral	0.67	neutral	1.97	neutral	0.37	neutral	-2.03	neutral_impact	0.2	0.59	damaging	0.24	damaging	3.48	23.10	deleterious	0.51	0.6	0.39	neutral	0.65	disease	0.42	neutral	0.4	neutral	2	0.99	deleterious	0.34	neutral	-2	neutral	0.75	deleterious	-2.58	low_impact	0.38	medium_impact	-0.92	medium_impact	0.53	0.8	29.07	72.35	0.38	N	0.41	polymorphism	0.92	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8056	8056	A	C	MI.6195	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	471	157	Q	H	caA/caC	6.98	1	0	probably_damaging	1	neutral	0.46	neutral	1.92	neutral	-2.04	neutral	-1.93	neutral_impact	-0.28	0.73	neutral	0.28	neutral	3.53	23.10	deleterious	0.49	0.55	0.62	disease	0.44	neutral	0.27	neutral	0.61	disease	2	1	deleterious	0.23	neutral	-2	neutral	0.73	deleterious	-3.52	low_impact	0.17	medium_impact	-1.37	low_impact	0.72	0.85	29.07	72.35	0.48	N	0.49	disease_causing	0.78	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8056	8056	A	T	MI.6196	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	471	157	Q	H	caA/caT	6.98	1	0	probably_damaging	1	neutral	0.46	neutral	1.92	neutral	-2.04	neutral	-1.93	neutral_impact	-0.28	0.73	neutral	0.28	neutral	3.69	23.30	deleterious	0.49	0.55	0.62	disease	0.44	neutral	0.27	neutral	0.61	disease	2	1	deleterious	0.23	neutral	-2	neutral	0.73	deleterious	-3.52	low_impact	0.17	medium_impact	-1.37	low_impact	0.72	0.85	29.07	72.35	0.5	N	0.49	disease_causing	0.78	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8057	8057	G	T	MI.6197	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	472	158	D	Y	Gac/Tac	0.75	0.99	0	probably_damaging	1	neutral	1	neutral	0.39	deleterious	-9.31	deleterious	-8.84	high_impact	4.7	0.16	damaging	0.02	damaging	4.01	23.60	deleterious	0.17	0.45	0.98	disease	0.89	disease	0.81	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.93	deleterious	-3.52	low_impact	1.86	high_impact	3.3	high_impact	0.39	0.8	68.72	19.58	0.61	P	0.99	disease_causing	0.99	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8057	8057	G	C	MI.6198	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	472	158	D	H	Gac/Cac	0.75	0.99	0	probably_damaging	1	neutral	0.6	neutral	0.4	deleterious	-8.44	deleterious	-6.87	high_impact	4.7	0.13	damaging	0.01	damaging	3.74	23.30	deleterious	0.27	0.45	0.96	disease	0.82	disease	0.81	disease	0.7	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.3	medium_impact	3.3	high_impact	0.66	0.8	68.72	19.58	0.75	P	0.98	disease_causing	0.98	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8057	8057	G	A	MI.6199	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	472	158	D	N	Gac/Aac	0.75	0.99	0	probably_damaging	1	neutral	0.48	neutral	0.43	deleterious	-6.48	deleterious	-4.91	high_impact	3.66	0.15	damaging	0.01	damaging	4.38	24.10	deleterious	0.37	0.5	0.88	disease	0.73	disease	0.77	disease	0.65	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.19	medium_impact	2.33	high_impact	0.81	0.85	68.72	19.58	0.86	P	0.99	disease_causing	0.93	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8554	8554	A	C	MI.62	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	28	10	I	L	Att/Ctt	-0.33	0	0	benign	0	neutral	0.11	neutral	4.72	neutral	0.19	neutral	-0.24	neutral_impact	0.46	0.81	neutral	0.79	neutral	-0.07	1.97	neutral	0.35	0.65	0.38	neutral	0.28	neutral	0.18	neutral	0.45	neutral	1	0.89	neutral	0.56	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	-0.22	medium_impact	-0.7	medium_impact	0.27	0.9	27.43	16.7	0.56	P	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8818	8818	C	G	MI.620	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	292	98	L	V	Cta/Gta	1.29	0.85	0.01	probably_damaging	0.99	neutral	0.05	neutral	4.29	neutral	-0.85	deleterious	-2.53	medium_impact	2.95	0.39	damaging	0.14	damaging	3.33	22.90	deleterious	0.38	0.65	0.49	neutral	0.43	neutral	0.62	disease	0.45	neutral	1	1	deleterious	0.03	neutral	1	deleterious	0.71	deleterious	-2.65	low_impact	-0.43	medium_impact	1.43	medium_impact	0.65	0.9	48.67	8.57	0.58	P	0.87	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8058	8058	A	G	MI.6200	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	473	158	D	G	gAc/gGc	5.13	1	0	probably_damaging	1	neutral	0.44	neutral	0.42	deleterious	-6.88	deleterious	-6.87	high_impact	4.36	0.14	damaging	0.02	damaging	4.06	23.70	deleterious	0.21	0.45	0.75	disease	0.81	disease	0.75	disease	0.68	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.15	medium_impact	2.98	high_impact	0.48	0.8	68.72	19.58	0.82	P	0.97	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8058	8058	A	C	MI.6201	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	473	158	D	A	gAc/gCc	5.13	1	0	probably_damaging	1	neutral	0.73	neutral	0.42	deleterious	-7.15	deleterious	-7.86	high_impact	4.01	0.22	damaging	0.08	damaging	3.71	23.30	deleterious	0.18	0.45	0.64	disease	0.78	disease	0.77	disease	0.69	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.44	medium_impact	2.65	high_impact	0.51	0.8	68.72	19.58	0.77	P	0.96	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8058	8058	A	T	MI.6202	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	473	158	D	V	gAc/gTc	5.13	1	0	probably_damaging	1	neutral	0.73	neutral	0.4	deleterious	-9.11	deleterious	-8.84	high_impact	4.7	0.14	damaging	0.01	damaging	3.80	23.40	deleterious	0.17	0.45	0.96	disease	0.89	disease	0.78	disease	0.64	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0.44	medium_impact	3.3	high_impact	0.33	0.8	68.72	19.58	0.71	P	0.99	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8059	8059	C	G	MI.6203	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	474	158	D	E	gaC/gaG	8.59	1	0	probably_damaging	0.99	neutral	0.61	neutral	0.47	deleterious	-5.37	deleterious	-3.93	high_impact	4.01	0.16	damaging	0.03	damaging	3.99	23.60	deleterious	0.3	0.45	0.82	disease	0.75	disease	0.68	disease	0.64	disease	3	0.99	deleterious	0.31	neutral	2	deleterious	0.88	deleterious	-2.58	low_impact	0.31	medium_impact	2.65	high_impact	0.56	0.8	68.72	19.58	0.85	P	0.95	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8059	8059	C	A	MI.6204	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	474	158	D	E	gaC/gaA	8.59	1	0	probably_damaging	0.99	neutral	0.61	neutral	0.47	deleterious	-5.37	deleterious	-3.93	high_impact	4.01	0.16	damaging	0.03	damaging	4.36	24.10	deleterious	0.3	0.45	0.82	disease	0.75	disease	0.68	disease	0.64	disease	3	0.99	deleterious	0.31	neutral	2	deleterious	0.88	deleterious	-2.58	low_impact	0.31	medium_impact	2.65	high_impact	0.56	0.8	68.72	19.58	0.86	P	0.95	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8060	8060	G	C	MI.6205	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	475	159	V	L	Gtc/Ctc	-8.7	0	0	probably_damaging	0.99	neutral	0.36	neutral	1.47	deleterious	-4.37	deleterious	-2.95	high_impact	4.74	0.13	damaging	0.03	damaging	3.70	23.30	deleterious	0.24	0.45	0.72	disease	0.7	disease	0.75	disease	0.7	disease	4	0.99	deleterious	0.19	neutral	2	deleterious	0.83	deleterious	-2.58	low_impact	0.07	medium_impact	3.34	high_impact	0.56	0.8	68.72	19.45	0.74	P	0.23	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8060	8060	G	A	MI.6206	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	475	159	V	I	Gtc/Atc	-8.7	0	0	probably_damaging	0.99	neutral	0.28	neutral	1.5	deleterious	-4.28	neutral	-0.98	high_impact	4.18	0.2	damaging	0.03	damaging	3.83	23.40	deleterious	0.34	0.5	0.51	disease	0.63	disease	0.71	disease	0.66	disease	3	0.99	deleterious	0.15	neutral	2	deleterious	0.74	deleterious	-2.58	low_impact	-0.02	medium_impact	2.81	high_impact	0.80	0.85	68.72	19.45	0.7	P	0.30	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8060	8060	G	T	MI.6207	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	475	159	V	F	Gtc/Ttc	-8.7	0	0	probably_damaging	1	deleterious	0.02	neutral	1.35	deleterious	-5.89	deleterious	-4.91	high_impact	4.74	0.14	damaging	0.02	damaging	3.94	23.50	deleterious	0.12	0.4	0.87	disease	0.87	disease	0.79	disease	0.64	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.52	low_impact	-0.73	medium_impact	3.34	high_impact	0.47	0.8	68.72	19.45	0.74	P	0.94	polymorphism	0.99	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8061	8061	T	C	MI.6208	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	476	159	V	A	gTc/gCc	6.06	1	0	probably_damaging	1	neutral	0.36	neutral	1.37	deleterious	-4.98	deleterious	-3.93	high_impact	4.18	0.2	damaging	0.1	damaging	3.66	23.20	deleterious	0.23	0.45	0.57	disease	0.63	disease	0.76	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	0.07	medium_impact	2.81	high_impact	0.35	0.8	68.72	19.45	0.89	P	0.59	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8061	8061	T	A	MI.6209	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	476	159	V	D	gTc/gAc	6.06	1	0	probably_damaging	1	neutral	0.37	neutral	1.31	deleterious	-7.75	deleterious	-6.87	high_impact	4.74	0.22	damaging	0.03	damaging	4.58	24.40	deleterious	0.07	0.35	0.95	disease	0.87	disease	0.84	disease	0.68	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.08	medium_impact	3.34	high_impact	0.25	0.8	68.72	19.45	0.78	P	0.90	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8819	8819	T	G	MI.621	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	293	98	L	R	cTa/cGa	-0.1	0.62	0	probably_damaging	1	deleterious	0	neutral	4.12	deleterious	-3.9	deleterious	-5.16	high_impact	4.37	0.35	damaging	0.13	damaging	4.13	23.80	deleterious	0.12	0.65	0.69	disease	0.8	disease	0.81	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	2.65	high_impact	0.53	0.9	48.67	8.57	0.71	P	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8061	8061	T	G	MI.6210	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	476	159	V	G	gTc/gGc	6.06	1	0	probably_damaging	1	neutral	0.17	neutral	1.32	deleterious	-6.84	deleterious	-6.87	high_impact	4.18	0.16	damaging	0.05	damaging	3.97	23.60	deleterious	0.11	0.4	0.9	disease	0.79	disease	0.79	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.18	medium_impact	2.81	high_impact	0.29	0.8	68.72	19.45	0.85	P	0.84	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8063	8063	T	A	MI.6211	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	478	160	L	M	Ttg/Atg	-20	0	0.01	probably_damaging	1	neutral	0.26	neutral	1.88	neutral	-2.07	neutral	-1.91	medium_impact	2.45	0.4	damaging	0.05	damaging	3.63	23.20	deleterious	0.24	0.45	0.41	neutral	0.58	disease	0.45	neutral	0.46	neutral	1	1	deleterious	0.13	neutral	1	deleterious	0.75	deleterious	-3.52	low_impact	-0.05	medium_impact	1.19	medium_impact	0.64	0.8	70.04	18.81	0.37	N	0.78	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8063	8063	T	G	MI.6212	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	478	160	L	V	Ttg/Gtg	-20	0	0.01	probably_damaging	0.99	neutral	0.76	neutral	1.9	neutral	-1.27	deleterious	-2.73	medium_impact	2.48	0.29	damaging	0.02	damaging	3.52	23.10	deleterious	0.21	0.45	0.42	neutral	0.67	disease	0.51	disease	0.51	disease	0	0.99	deleterious	0.39	neutral	1	deleterious	0.76	deleterious	-2.58	low_impact	0.48	medium_impact	1.22	medium_impact	0.55	0.8	70.04	18.81	0.5	P	0.66	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8064	8064	T	C	MI.6213	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	479	160	L	S	tTg/tCg	-0.4	0	0	probably_damaging	1	neutral	0.75	neutral	1.84	neutral	-2.63	deleterious	-5.78	medium_impact	3.35	0.35	damaging	0.02	damaging	3.88	23.50	deleterious	0.15	0.4	0.69	disease	0.8	disease	0.62	disease	0.65	disease	3	1	deleterious	0.38	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.47	medium_impact	2.04	high_impact	0.48	0.8	70.04	18.81	0.38	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8064	8064	T	G	MI.6214	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	479	160	L	W	tTg/tGg	-0.4	0	0	probably_damaging	1	neutral	0.21	neutral	1.8	deleterious	-4.24	deleterious	-5.84	high_impact	3.54	0.23	damaging	0.01	damaging	3.91	23.50	deleterious	0.1	0.4	0.9	disease	0.81	disease	0.64	disease	0.64	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.11	medium_impact	2.21	high_impact	0.40	0.8	70.04	18.81	0.73	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8065	8065	G	C	MI.6215	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	480	160	L	F	ttG/ttC	7.44	0.96	0.01	probably_damaging	1	neutral	0.66	neutral	1.83	neutral	-2.77	deleterious	-3.82	high_impact	3.54	0.29	damaging	0.02	damaging	3.60	23.20	deleterious	0.24	0.45	0.69	disease	0.72	disease	0.62	disease	0.64	disease	3	1	deleterious	0.33	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.36	medium_impact	2.21	high_impact	0.64	0.8	70.04	18.81	0.73	P	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8065	8065	G	T	MI.6216	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	480	160	L	F	ttG/ttT	7.44	0.96	0.01	probably_damaging	1	neutral	0.66	neutral	1.83	neutral	-2.77	deleterious	-3.82	high_impact	3.54	0.29	damaging	0.02	damaging	3.75	23.30	deleterious	0.24	0.45	0.69	disease	0.72	disease	0.62	disease	0.64	disease	3	1	deleterious	0.33	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.36	medium_impact	2.21	high_impact	0.64	0.8	70.04	18.81	0.74	P	0.91	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8066	8066	C	G	MI.6217	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	481	161	H	D	Cac/Gac	-12.39	0	0	probably_damaging	1	neutral	0.22	neutral	1.04	deleterious	-6.55	deleterious	-8.83	high_impact	4.72	0.34	damaging	0.17	damaging	4.00	23.60	deleterious	0.15	0.4	0.88	disease	0.79	disease	0.88	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.1	medium_impact	3.32	high_impact	0.38	0.8	68.72	19.9	0.59	P	0.97	polymorphism	0.93	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8066	8066	C	A	MI.6218	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	481	161	H	N	Cac/Aac	-12.39	0	0	probably_damaging	1	neutral	0.31	neutral	1.1	deleterious	-5.8	deleterious	-6.87	high_impact	4.72	0.32	damaging	0.18	damaging	4.01	23.60	deleterious	0.22	0.45	0.74	disease	0.75	disease	0.83	disease	0.69	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.01	medium_impact	3.32	high_impact	0.48	0.8	68.72	19.9	0.63	P	0.96	polymorphism	0.98	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8066	8066	C	T	MI.6219	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	481	161	H	Y	Cac/Tac	-12.39	0	0	probably_damaging	0.99	neutral	1	neutral	1.02	deleterious	-7.03	deleterious	-5.89	high_impact	4.72	0.31	damaging	0.12	damaging	3.83	23.40	deleterious	0.2	0.45	0.92	disease	0.8	disease	0.84	disease	0.69	disease	4	0.99	deleterious	0.51	deleterious	2	deleterious	0.89	deleterious	-2.58	low_impact	1.86	high_impact	3.32	high_impact	0.39	0.8	68.72	19.9	0.59	P	0.99	polymorphism	0.97	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8819	8819	T	A	MI.622	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	293	98	L	Q	cTa/cAa	-0.1	0.62	0	probably_damaging	1	deleterious	0	neutral	4.12	deleterious	-3.95	deleterious	-5.16	high_impact	4.37	0.43	damaging	0.14	damaging	4.24	23.90	deleterious	0.16	0.65	0.88	disease	0.73	disease	0.71	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	2.65	high_impact	0.72	0.9	48.67	8.57	0.51	P	0.98	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8067	8067	A	G	MI.6220	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	482	161	H	R	cAc/cGc	5.6	1	0	probably_damaging	1	neutral	0.34	neutral	1.05	deleterious	-6.36	deleterious	-7.85	high_impact	4.72	0.32	damaging	0.15	damaging	3.14	22.60	deleterious	0.22	0.45	0.87	disease	0.82	disease	0.86	disease	0.65	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.05	medium_impact	3.32	high_impact	0.37	0.8	68.72	19.9	0.79	P	0.95	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8067	8067	A	T	MI.6221	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	482	161	H	L	cAc/cTc	5.6	1	0	probably_damaging	1	neutral	0.65	neutral	1.03	deleterious	-6.85	deleterious	-10.8	high_impact	4.72	0.28	damaging	0.31	neutral	4.00	23.60	deleterious	0.13	0.4	0.59	disease	0.84	disease	0.84	disease	0.72	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.35	medium_impact	3.32	high_impact	0.42	0.8	68.72	19.9	0.83	P	0.91	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8067	8067	A	C	MI.6222	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	482	161	H	P	cAc/cCc	5.6	1	0	probably_damaging	1	neutral	0.21	neutral	1.02	deleterious	-7.93	deleterious	-9.81	high_impact	4.38	0.3	damaging	0.18	damaging	3.40	23.00	deleterious	0.13	0.4	0.93	disease	0.83	disease	0.83	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.11	medium_impact	3	high_impact	0.34	0.8	68.72	19.9	0.75	P	0.98	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8068	8068	C	G	MI.6223	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	483	161	H	Q	caC/caG	6.98	1	0	probably_damaging	1	neutral	0.29	neutral	1.04	deleterious	-6.75	deleterious	-7.85	high_impact	4.72	0.32	damaging	0.2	damaging	3.71	23.30	deleterious	0.23	0.45	0.88	disease	0.75	disease	0.84	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.01	medium_impact	3.32	high_impact	0.49	0.8	68.72	19.9	0.8	P	0.94	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8068	8068	C	A	MI.6224	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	483	161	H	Q	caC/caA	6.98	1	0	probably_damaging	1	neutral	0.29	neutral	1.04	deleterious	-6.75	deleterious	-7.85	high_impact	4.72	0.32	damaging	0.2	damaging	3.94	23.50	deleterious	0.23	0.45	0.88	disease	0.75	disease	0.84	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.01	medium_impact	3.32	high_impact	0.49	0.8	68.72	19.9	0.81	P	0.94	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8069	8069	T	C	MI.6225	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	484	162	S	P	Tca/Cca	0.75	1	0	probably_damaging	1	neutral	0.32	neutral	1.44	deleterious	-4.47	deleterious	-4.88	high_impact	3.99	0.41	damaging	0.35	neutral	4.17	23.80	deleterious	0.16	0.45	0.91	disease	0.8	disease	0.71	disease	0.65	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.02	medium_impact	2.64	high_impact	0.71	0.85	66.96	19.91	0.65	P	0.83	disease_causing	0.84	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8069	8069	T	A	MI.6226	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	484	162	S	T	Tca/Aca	0.75	1	0	probably_damaging	0.97	neutral	0.69	neutral	1.46	deleterious	-3.83	deleterious	-2.93	high_impact	3.85	0.33	damaging	0.39	neutral	4.06	23.70	deleterious	0.18	0.45	0.79	disease	0.65	disease	0.72	disease	0.66	disease	3	0.97	neutral	0.36	neutral	2	deleterious	0.84	deleterious	-2.13	low_impact	0.4	medium_impact	2.5	high_impact	0.80	0.85	66.96	19.91	0.68	P	0.62	polymorphism	0.55	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8069	8069	T	G	MI.6227	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	484	162	S	A	Tca/Gca	0.75	1	0	probably_damaging	0.99	neutral	0.9	neutral	1.59	neutral	-1.89	deleterious	-2.9	medium_impact	2.07	0.56	damaging	0.81	neutral	2.75	21.10	deleterious	0.23	0.45	0.48	neutral	0.52	disease	0.51	disease	0.17	neutral	7	0.98	deleterious	0.46	neutral	1	deleterious	0.75	deleterious	-2.58	low_impact	0.73	medium_impact	0.84	medium_impact	0.83	0.85	66.96	19.91	0.4	N	0.15	polymorphism	0.8	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8070	8070	C	G	MI.6228	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	485	162	S	W	tCa/tGa	5.83	1	0	probably_damaging	1	neutral	0.14	neutral	1.41	deleterious	-7.35	deleterious	-6.85	high_impact	4.54	0.32	damaging	0.36	neutral	4.50	24.30	deleterious	0.09	0.35	0.97	disease	0.87	disease	0.76	disease	0.64	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.23	medium_impact	3.15	high_impact	0.44	0.8	66.96	19.91	0.73	P	0.99	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8070	8070	C	T	MI.6229	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	485	162	S	L	tCa/tTa	5.83	1	0	probably_damaging	1	neutral	0.55	neutral	1.43	deleterious	-5.33	deleterious	-5.86	high_impact	3.85	0.31	damaging	0.36	neutral	4.83	24.80	deleterious	0.11	0.4	0.58	disease	0.81	disease	0.69	disease	0.67	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.25	medium_impact	2.5	high_impact	0.82	0.85	66.96	19.91	0.76	P	0.94	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8819	8819	T	C	MI.623	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	293	98	L	P	cTa/cCa	-0.1	0.62	0	probably_damaging	1	neutral	0.13	neutral	4.18	deleterious	-3.8	deleterious	-6.06	medium_impact	3.17	0.46	damaging	0.17	damaging	3.97	23.60	deleterious	0.13	0.65	0.74	disease	0.71	disease	0.76	disease	0.71	disease	4	1	deleterious	0.07	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	-0.18	medium_impact	1.62	medium_impact	0.57	0.9	48.67	8.57	0.4	N	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8072	8072	T	C	MI.6230	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	487	163	W	R	Tga/Cga	-0.86	0.03	0	probably_damaging	1	neutral	0.58	neutral	1.61	deleterious	-5.05	deleterious	-13.75	high_impact	4.49	0.19	damaging	0.01	damaging	3.68	23.30	deleterious	0.23	0.45	0.41	neutral	0.88	disease	0.83	disease	0.74	disease	5	1	deleterious	0.29	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.28	medium_impact	3.1	high_impact	0.20	0.8	68.72	19.55	0.58	P	0.96	disease_causing	0.96	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8072	8072	T	G	MI.6231	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	487	163	W	G	Tga/Gga	-0.86	0.03	0	probably_damaging	1	neutral	0.45	neutral	1.61	deleterious	-5.28	deleterious	-12.76	high_impact	4.14	0.16	damaging	0.01	damaging	4.05	23.70	deleterious	0.19	0.45	0.81	disease	0.83	disease	0.8	disease	0.69	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.16	medium_impact	2.78	high_impact	0.23	0.8	68.72	19.55	0.63	P	0.98	disease_causing	0.98	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8073	8073	G	C	MI.6232	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	488	163	W	S	tGa/tCa	7.44	1	0	probably_damaging	1	neutral	0.79	neutral	1.62	deleterious	-4.38	deleterious	-13.74	high_impact	3.94	0.14	damaging	0.01	damaging	4.16	23.80	deleterious	0.19	0.45	0.7	disease	0.9	disease	0.78	disease	0.71	disease	4	1	deleterious	0.4	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.52	medium_impact	2.59	high_impact	0.19	0.8	68.72	19.55	0.69	P	0.97	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8073	8073	G	T	MI.6233	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	488	163	W	L	tGa/tTa	7.44	1	0	probably_damaging	1	neutral	0.45	neutral	1.67	neutral	-2.65	deleterious	-12.76	high_impact	3.59	0.2	damaging	0.02	damaging	4.37	24.10	deleterious	0.18	0.45	0.27	neutral	0.81	disease	0.78	disease	0.68	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.77	deleterious	-3.52	low_impact	0.16	medium_impact	2.26	high_impact	0.24	0.8	68.72	19.55	0.74	P	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8074	8074	A	T	MI.6234	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	489	163	W	C	tgA/tgT	9.29	1	0	probably_damaging	1	neutral	0.1	neutral	1.61	deleterious	-5.89	deleterious	-12.76	high_impact	4.49	0.16	damaging	0.01	damaging	4.25	23.90	deleterious	0.22	0.45	0.85	disease	0.88	disease	0.81	disease	0.66	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.32	medium_impact	3.1	high_impact	0.26	0.8	68.72	19.55	0.77	P	0.94	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8074	8074	A	C	MI.6235	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	489	163	W	C	tgA/tgC	9.29	1	0	probably_damaging	1	neutral	0.1	neutral	1.61	deleterious	-5.89	deleterious	-12.76	high_impact	4.49	0.16	damaging	0.01	damaging	4.17	23.80	deleterious	0.22	0.45	0.85	disease	0.88	disease	0.81	disease	0.66	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.32	medium_impact	3.1	high_impact	0.26	0.8	68.72	19.55	0.76	P	0.94	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8075	8075	G	C	MI.6236	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	490	164	A	P	Gct/Cct	2.37	1	0	probably_damaging	0.91	neutral	0.26	neutral	1.85	deleterious	-3.53	deleterious	-4.46	high_impact	4.03	0.35	damaging	0.3	neutral	3.92	23.50	deleterious	0.11	0.4	0.87	disease	0.83	disease	0.65	disease	0.66	disease	3	0.93	neutral	0.18	neutral	2	deleterious	0.80	deleterious	-1.66	low_impact	-0.05	medium_impact	2.67	high_impact	0.83	0.9	27.75	50.21	0.67	P	0.83	disease_causing	0.86	0.18	rs386829024	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8075	8075	G	A	MI.6237	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	490	164	A	T	Gct/Act	2.37	1	0	benign	0	neutral	0.52	neutral	2.02	neutral	-1.5	deleterious	-2.93	neutral_impact	0.48	0.76	neutral	0.86	neutral	0.64	8.41	deleterious	0.46	0.55	0.68	disease	0.06	neutral	0.21	neutral	0.41	neutral	2	0.47	neutral	0.76	deleterious	-6	neutral	0.19	neutral	2.08	high_impact	0.22	medium_impact	-0.66	medium_impact	0.73	0.85	27.75	50.21	0.47	N	0.00	disease_causing	0.63	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8075	8075	G	T	MI.6238	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	490	164	A	S	Gct/Tct	2.37	1	0	benign	0.19	neutral	0.52	neutral	1.9	neutral	-1.6	neutral	-2.5	medium_impact	2.08	0.47	damaging	0.43	neutral	2.01	16.25	deleterious	0.42	0.55	0.73	disease	0.59	disease	0.49	neutral	0.36	neutral	3	0.38	neutral	0.67	deleterious	-3	neutral	0.32	neutral	-0.13	medium_impact	0.22	medium_impact	0.85	medium_impact	0.86	0.9	27.75	50.21	0.5	N	0.47	polymorphism	0.57	0.04	rs386829024	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8076	8076	C	T	MI.6239	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	491	164	A	V	gCt/gTt	4.21	1	0	benign	0.12	neutral	0.58	neutral	1.91	neutral	-1.21	deleterious	-3.48	medium_impact	3.34	0.45	damaging	0.33	neutral	2.59	20.10	deleterious	0.31	0.5	0.64	disease	0.61	disease	0.68	disease	0.69	disease	4	0.32	neutral	0.73	deleterious	-3	neutral	0.45	deleterious	0.09	medium_impact	0.28	medium_impact	2.03	high_impact	0.75	0.85	27.75	50.21	0.62	P	0.48	disease_causing	0.62	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8821	8821	T	C	MI.624	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	295	99	S	P	Tct/Cct	-2.42	0	0	probably_damaging	0.99	neutral	0.1	neutral	3.78	deleterious	-3.23	deleterious	-4.37	high_impact	4.12	0.42	damaging	0.57	neutral	3.90	23.50	deleterious	0.18	0.65	0.8	disease	0.82	disease	0.77	disease	0.73	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-2.65	low_impact	-0.25	medium_impact	2.43	high_impact	0.71	0.9	43.36	8.06	0.6	P	0.99	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8076	8076	C	G	MI.6240	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	491	164	A	G	gCt/gGt	4.21	1	0	benign	0.08	neutral	0.37	neutral	1.89	neutral	-1.6	deleterious	-3.7	medium_impact	2.75	0.46	damaging	0.47	neutral	2.17	17.32	deleterious	0.33	0.5	0.87	disease	0.59	disease	0.64	disease	0.66	disease	3	0.59	neutral	0.65	deleterious	-3	neutral	0.33	neutral	0.27	medium_impact	0.08	medium_impact	1.47	medium_impact	0.81	0.85	27.75	50.21	0.54	P	0.54	disease_causing	0.57	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8076	8076	C	A	MI.6241	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	491	164	A	D	gCt/gAt	4.21	1	0	possibly_damaging	0.81	neutral	0.3	neutral	1.84	deleterious	-3.37	deleterious	-5.33	high_impact	3.68	0.49	damaging	0.31	neutral	4.48	24.20	deleterious	0.17	0.45	0.92	disease	0.83	disease	0.75	disease	0.65	disease	3	0.84	neutral	0.25	neutral	1	deleterious	0.70	deleterious	-1.31	low_impact	0	medium_impact	2.35	high_impact	0.61	0.8	27.75	50.21	0.57	P	0.95	disease_causing	0.88	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8078	8078	G	T	MI.6242	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	493	165	V	F	Gtc/Ttc	-16.08	0	0	possibly_damaging	0.5	neutral	0.75	neutral	1.42	deleterious	-5.25	deleterious	-4.21	high_impact	3.7	0.47	damaging	0.41	neutral	3.61	23.20	deleterious	0.17	0.45	0.93	disease	0.82	disease	0.71	disease	0.66	disease	3	0.4	neutral	0.63	deleterious	1	deleterious	0.57	deleterious	-0.72	medium_impact	0.47	medium_impact	2.36	high_impact	0.58	0.8	28.19	35.21	0.29	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8078	8078	G	A	MI.6243	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	493	165	V	I	Gtc/Atc	-16.08	0	0	benign	0	neutral	0.48	neutral	1.98	neutral	-0.06	neutral	-0.36	neutral_impact	0.52	0.89	neutral	0.95	neutral	0.12	3.83	deleterious	0.51	0.6	0.34	neutral	0.06	neutral	0.23	neutral	0.24	neutral	5	0.52	neutral	0.74	deleterious	-6	neutral	0.14	neutral	2.08	high_impact	0.19	medium_impact	-0.62	medium_impact	0.97	1	28.19	35.21	0.55	N	0.06	polymorphism	1	0.00	rs878993263	.	.	.	.	.	.	.	.	G8078A	DEAF	+	-	Reported	2	N	P	N,P	neutral
chrM	8078	8078	G	C	MI.6244	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	493	165	V	L	Gtc/Ctc	-16.08	0	0	benign	0.01	neutral	0.76	neutral	1.6	neutral	-1.79	neutral	-2.2	low_impact	1.08	0.57	damaging	0.54	neutral	0.75	9.12	deleterious	0.37	0.5	0.51	disease	0.52	disease	0.39	neutral	0.19	neutral	6	0.21	neutral	0.88	deleterious	-6	neutral	0.24	neutral	1.14	medium_impact	0.48	medium_impact	-0.09	medium_impact	0.74	0.85	28.19	35.21	0.27	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8079	8079	T	A	MI.6245	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	494	165	V	D	gTc/gAc	0.29	0.05	0	possibly_damaging	0.74	neutral	0.21	neutral	1.4	deleterious	-7.83	deleterious	-6.5	high_impact	4.05	0.48	damaging	0.34	neutral	4.40	24.10	deleterious	0.09	0.4	0.98	disease	0.85	disease	0.79	disease	0.76	disease	5	0.85	neutral	0.24	neutral	1	deleterious	0.79	deleterious	-1.14	low_impact	-0.11	medium_impact	2.69	high_impact	0.54	0.8	28.19	35.21	0.44	N	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8079	8079	T	C	MI.6246	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	494	165	V	A	gTc/gCc	0.29	0.05	0	benign	0.34	neutral	0.58	neutral	1.49	deleterious	-3.02	deleterious	-3.86	medium_impact	2.9	0.53	damaging	0.56	neutral	2.05	16.54	deleterious	0.3	0.45	0.89	disease	0.51	disease	0.68	disease	0.7	disease	4	0.34	neutral	0.62	deleterious	-3	neutral	0.42	neutral	-0.45	medium_impact	0.28	medium_impact	1.61	medium_impact	0.54	0.8	28.19	35.21	0.3	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8079	8079	T	G	MI.6247	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	494	165	V	G	gTc/gGc	0.29	0.05	0	possibly_damaging	0.79	neutral	0.33	neutral	1.41	deleterious	-6.59	deleterious	-6.79	high_impact	4.05	0.51	damaging	0.51	neutral	3.80	23.40	deleterious	0.16	0.45	0.98	disease	0.73	disease	0.71	disease	0.72	disease	4	0.82	neutral	0.27	neutral	1	deleterious	0.73	deleterious	-1.26	low_impact	0.04	medium_impact	2.69	high_impact	0.48	0.8	28.19	35.21	0.35	N	0.94	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8081	8081	C	G	MI.6248	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	496	166	P	A	Ccc/Gcc	-15.39	0	0	probably_damaging	1	neutral	0.56	neutral	1.37	deleterious	-3.64	deleterious	-7.58	high_impact	3.81	0.15	damaging	0.11	damaging	3.22	22.70	deleterious	0.19	0.45	0.77	disease	0.69	disease	0.7	disease	0.68	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.26	medium_impact	2.47	high_impact	0.59	0.8	68.72	19.6	0.53	P	0.90	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8081	8081	C	A	MI.6249	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	496	166	P	T	Ccc/Acc	-15.39	0	0	probably_damaging	1	neutral	0.54	neutral	1.36	deleterious	-4.04	deleterious	-7.58	high_impact	4.15	0.1	damaging	0.02	damaging	3.82	23.40	deleterious	0.22	0.45	0.81	disease	0.8	disease	0.63	disease	0.65	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.24	medium_impact	2.79	high_impact	0.62	0.8	68.72	19.6	0.47	P	0.96	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8821	8821	T	G	MI.625	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	295	99	S	A	Tct/Gct	-2.42	0	0	probably_damaging	0.97	neutral	0.34	neutral	3.88	neutral	0.26	deleterious	-2.51	low_impact	1.9	0.72	neutral	0.62	neutral	3.59	23.20	deleterious	0.44	0.65	0.35	neutral	0.37	neutral	0.53	disease	0.43	neutral	1	0.97	neutral	0.19	neutral	-2	neutral	0.68	deleterious	-2.19	low_impact	0.13	medium_impact	0.53	medium_impact	0.81	0.9	43.36	8.06	0.37	N	0.45	disease_causing	0.98	0.07	.	.	.	.	.	.	.	.	.	T8821G	Possible LHON helper variant	.	.	Reported	1	.	.	.	damaging
chrM	8081	8081	C	T	MI.6250	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	496	166	P	S	Ccc/Tcc	-15.39	0	0	probably_damaging	1	neutral	0.5	neutral	1.37	deleterious	-3.98	deleterious	-7.54	medium_impact	3.46	0.11	damaging	0.03	damaging	4.04	23.70	deleterious	0.31	0.5	0.82	disease	0.83	disease	0.7	disease	0.67	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	0.21	medium_impact	2.14	high_impact	0.24	0.8	68.72	19.6	0.54	P	0.94	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8082	8082	C	T	MI.6251	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	497	166	P	L	cCc/cTc	7.21	1	0	probably_damaging	1	neutral	0.78	neutral	1.38	deleterious	-3.88	deleterious	-9.48	high_impact	4.7	0.08	damaging	0.02	damaging	4.56	24.40	deleterious	0.25	0.45	0.64	disease	0.86	disease	0.69	disease	0.69	disease	4	1	deleterious	0.39	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.51	medium_impact	3.3	high_impact	0.87	0.9	68.72	19.6	0.74	P	0.92	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8082	8082	C	A	MI.6252	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	497	166	P	H	cCc/cAc	7.21	1	0	probably_damaging	1	neutral	0.56	neutral	1.32	deleterious	-5.54	deleterious	-8.59	high_impact	4.7	0.08	damaging	0.02	damaging	4.18	23.80	deleterious	0.18	0.45	0.92	disease	0.86	disease	0.8	disease	0.64	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.26	medium_impact	3.3	high_impact	0.56	0.8	68.72	19.6	0.8	P	0.79	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8082	8082	C	G	MI.6253	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	497	166	P	R	cCc/cGc	7.21	1	0	probably_damaging	1	neutral	0.35	neutral	1.34	deleterious	-4.57	deleterious	-8.58	high_impact	4.35	0.12	damaging	0.02	damaging	3.74	23.30	deleterious	0.16	0.45	0.88	disease	0.89	disease	0.82	disease	0.64	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.06	medium_impact	2.97	high_impact	0.51	0.8	68.72	19.6	0.83	P	0.85	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8084	8084	A	T	MI.6254	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	499	167	T	S	Aca/Tca	-11.7	0	0	benign	0	neutral	0.47	neutral	2.23	neutral	2.25	neutral	0.88	neutral_impact	-2.54	0.85	neutral	0.99	neutral	-1.09	0.01	neutral	0.55	0.6	0.49	neutral	0.05	neutral	0.12	neutral	0.23	neutral	6	0.52	neutral	0.74	deleterious	-6	neutral	0.13	neutral	2.08	high_impact	0.18	medium_impact	-3.49	low_impact	0.64	0.8	29.07	54.15	0.5	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8084	8084	A	G	MI.6255	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	499	167	T	A	Aca/Gca	-11.7	0	0	benign	0	neutral	0.55	neutral	2.1	neutral	1.37	neutral	0.22	neutral_impact	-1.3	0.78	neutral	0.9	neutral	-0.26	0.83	neutral	0.64	0.7	0.44	neutral	0.15	neutral	0.19	neutral	0.31	neutral	4	0.44	neutral	0.78	deleterious	-6	neutral	0.15	neutral	2.08	high_impact	0.25	medium_impact	-2.32	low_impact	0.46	0.8	29.07	54.15	0.46	N	0.20	polymorphism	1	0.00	rs1057518824	Uncertain_significance	Ischemic_stroke|Focal_white_matter_lesions	361110	Human_Phenotype_Ontology:HP:0002140,MedGen:C0948008,OMIM:601367,SNOMED_CT:422504002|Human_Phenotype_Ontology:HP:0007042,MedGen:C4024946	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8084	8084	A	C	MI.6256	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	499	167	T	P	Aca/Cca	-11.7	0	0	benign	0.38	neutral	0.23	neutral	1.99	neutral	-0.25	neutral	-2.24	low_impact	1.21	0.63	neutral	0.44	neutral	2.02	16.35	deleterious	0.22	0.45	0.34	neutral	0.81	disease	0.32	neutral	0.62	disease	2	0.73	neutral	0.43	neutral	-6	neutral	0.39	neutral	-0.52	medium_impact	-0.09	medium_impact	0.03	medium_impact	0.42	0.8	29.07	54.15	0.39	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8085	8085	C	A	MI.6257	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	500	167	T	K	aCa/aAa	-0.17	0	0	benign	0.15	neutral	0.29	neutral	2.03	neutral	0.53	neutral	-1.93	neutral_impact	0.38	0.63	neutral	0.55	neutral	2.84	21.60	deleterious	0.33	0.5	0.28	neutral	0.67	disease	0.53	disease	0.57	disease	1	0.66	neutral	0.57	deleterious	-6	neutral	0.27	neutral	-0.02	medium_impact	-0.01	medium_impact	-0.75	medium_impact	0.73	0.85	29.07	54.15	0.38	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8085	8085	C	T	MI.6258	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	500	167	T	M	aCa/aTa	-0.17	0	0	possibly_damaging	0.73	neutral	0.23	neutral	1.94	neutral	-2.89	neutral	-2.41	neutral_impact	0.79	0.71	neutral	0.55	neutral	4.00	23.60	deleterious	0.36	0.5	0.67	disease	0.53	disease	0.38	neutral	0.45	neutral	1	0.83	neutral	0.25	neutral	-3	neutral	0.58	deleterious	-1.12	low_impact	-0.09	medium_impact	-0.37	medium_impact	0.63	0.8	29.07	54.15	0.34	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8087	8087	T	A	MI.6259	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	502	168	L	M	Tta/Ata	-5.47	0	0	probably_damaging	1	neutral	0.16	neutral	1.66	neutral	-2.41	neutral	-1.45	low_impact	1.5	0.53	damaging	0.44	neutral	2.60	20.20	deleterious	0.38	0.5	0.84	disease	0.31	neutral	0.32	neutral	0.62	disease	2	1	deleterious	0.08	neutral	-2	neutral	0.78	deleterious	-3.52	low_impact	-0.19	medium_impact	0.3	medium_impact	0.73	0.85	68.72	19.34	0.4	N	0.78	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8821	8821	T	A	MI.626	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	295	99	S	T	Tct/Act	-2.42	0	0	probably_damaging	0.98	neutral	0.28	neutral	3.85	neutral	-0.9	neutral	-2.37	medium_impact	2.6	0.81	neutral	0.61	neutral	3.73	23.30	deleterious	0.36	0.65	0.53	disease	0.5	disease	0.54	disease	0.37	neutral	3	0.98	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-2.36	low_impact	0.06	medium_impact	1.13	medium_impact	0.91	0.95	43.36	8.06	0.32	N	0.67	disease_causing	0.99	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8087	8087	T	G	MI.6260	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	502	168	L	V	Tta/Gta	-5.47	0	0	probably_damaging	0.98	neutral	0.38	neutral	1.68	neutral	-1.94	deleterious	-2.71	medium_impact	3.3	0.33	damaging	0.04	damaging	3.55	23.10	deleterious	0.39	0.5	0.6	disease	0.58	disease	0.67	disease	0.55	disease	1	0.99	deleterious	0.2	neutral	1	deleterious	0.79	deleterious	-2.3	low_impact	0.09	medium_impact	1.99	medium_impact	0.54	0.8	68.72	19.34	0.48	N	0.66	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8088	8088	T	C	MI.6261	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	503	168	L	S	tTa/tCa	-1.32	0	0	probably_damaging	1	neutral	0.79	neutral	1.64	deleterious	-3.31	deleterious	-5.42	medium_impact	3.19	0.31	damaging	0.05	damaging	3.94	23.50	deleterious	0.24	0.45	0.83	disease	0.75	disease	0.66	disease	0.6	disease	2	1	deleterious	0.4	neutral	1	deleterious	0.87	deleterious	-3.52	low_impact	0.52	medium_impact	1.89	medium_impact	0.61	0.8	68.72	19.34	0.44	N	0.94	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8088	8088	T	G	MI.6262	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	503	168	L	W	tTa/tGa	-1.32	0	0	probably_damaging	1	deleterious	0.04	neutral	1.61	deleterious	-4.99	deleterious	-5.44	high_impact	3.79	0.31	damaging	0.02	damaging	3.93	23.50	deleterious	0.22	0.45	0.96	disease	0.74	disease	0.69	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.87	deleterious	-3.52	low_impact	-0.56	medium_impact	2.45	high_impact	0.51	0.8	68.72	19.34	0.51	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8089	8089	A	C	MI.6263	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	504	168	L	F	ttA/ttC	5.6	0.88	0	probably_damaging	1	neutral	0.09	neutral	1.77	neutral	-0.12	deleterious	-3.54	low_impact	1.62	0.45	damaging	0.03	damaging	3.61	23.20	deleterious	0.36	0.5	0.37	neutral	0.67	disease	0.53	disease	0.46	neutral	1	1	deleterious	0.05	neutral	-2	neutral	0.76	deleterious	-3.52	low_impact	-0.35	medium_impact	0.41	medium_impact	0.63	0.8	68.72	19.34	0.45	N	0.91	polymorphism	0.73	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8089	8089	A	T	MI.6264	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	504	168	L	F	ttA/ttT	5.6	0.88	0	probably_damaging	1	neutral	0.09	neutral	1.77	neutral	-0.12	deleterious	-3.54	low_impact	1.62	0.45	damaging	0.03	damaging	3.69	23.30	deleterious	0.36	0.5	0.37	neutral	0.67	disease	0.53	disease	0.46	neutral	1	1	deleterious	0.05	neutral	-2	neutral	0.76	deleterious	-3.52	low_impact	-0.35	medium_impact	0.41	medium_impact	0.63	0.8	68.72	19.34	0.46	N	0.91	polymorphism	0.73	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8090	8090	G	C	MI.6265	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	505	169	G	R	Ggc/Cgc	-5.47	0	0	probably_damaging	0.97	neutral	0.36	neutral	1.65	neutral	-2.19	deleterious	-7.58	high_impact	3.9	0.29	damaging	0.1	damaging	4.06	23.70	deleterious	0.36	0.5	0.38	neutral	0.86	disease	0.78	disease	0.69	disease	4	0.97	neutral	0.2	neutral	2	deleterious	0.82	deleterious	-2.13	low_impact	0.07	medium_impact	2.55	high_impact	0.91	0.95	67.4	19.84	0.63	P	1.00	disease_causing	0.7	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8090	8090	G	A	MI.6266	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	505	169	G	S	Ggc/Agc	-5.47	0	0	possibly_damaging	0.72	neutral	0.41	neutral	1.63	neutral	-2.54	deleterious	-5.66	medium_impact	2.69	0.29	damaging	0.16	damaging	4.16	23.80	deleterious	0.38	0.5	0.64	disease	0.74	disease	0.63	disease	0.35	neutral	3	0.73	neutral	0.35	neutral	0	NA	0.71	deleterious	-1.1	low_impact	0.12	medium_impact	1.42	medium_impact	0.77	0.85	67.4	19.84	0.7	P	0.98	disease_causing	0.52	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8090	8090	G	T	MI.6267	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	505	169	G	C	Ggc/Tgc	-5.47	0	0	probably_damaging	0.98	neutral	0.18	neutral	1.55	deleterious	-5.82	deleterious	-8.59	medium_impact	3.21	0.28	damaging	0.12	damaging	4.32	24.00	deleterious	0.24	0.45	0.94	disease	0.87	disease	0.73	disease	0.61	disease	2	0.99	deleterious	0.1	neutral	1	deleterious	0.89	deleterious	-2.3	low_impact	-0.16	medium_impact	1.9	medium_impact	0.61	0.8	67.4	19.84	0.67	P	0.99	disease_causing	0.82	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8091	8091	G	T	MI.6268	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	506	169	G	V	gGc/gTc	7.44	1	0	probably_damaging	0.97	neutral	0.52	neutral	1.57	deleterious	-4.23	deleterious	-8.59	high_impact	3.9	0.29	damaging	0.13	damaging	3.86	23.50	deleterious	0.25	0.45	0.79	disease	0.86	disease	0.75	disease	0.67	disease	3	0.97	neutral	0.28	neutral	2	deleterious	0.87	deleterious	-2.13	low_impact	0.22	medium_impact	2.55	high_impact	0.55	0.8	67.4	19.84	0.78	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8091	8091	G	A	MI.6269	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	506	169	G	D	gGc/gAc	7.44	1	0	benign	0.07	neutral	0.22	neutral	1.63	neutral	-2.48	deleterious	-6.7	high_impact	4.46	0.35	damaging	0.11	damaging	2.11	16.93	deleterious	0.28	0.45	0.77	disease	0.87	disease	0.76	disease	0.68	disease	4	0.76	neutral	0.58	deleterious	-2	neutral	0.37	neutral	0.33	medium_impact	-0.1	medium_impact	3.08	high_impact	0.53	0.8	67.4	19.84	0.71	P	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8822	8822	C	G	MI.627	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	296	99	S	C	tCt/tGt	3.83	0.99	0	probably_damaging	1	neutral	0.08	neutral	3.77	deleterious	-4.35	deleterious	-4.31	medium_impact	3.08	0.59	damaging	0.46	neutral	3.46	23.00	deleterious	0.24	0.65	0.88	disease	0.74	disease	0.69	disease	0.71	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.31	medium_impact	1.54	medium_impact	0.80	0.9	43.36	8.06	0.45	N	0.99	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8091	8091	G	C	MI.6270	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	506	169	G	A	gGc/gCc	7.44	1	0	possibly_damaging	0.56	neutral	0.51	neutral	1.64	neutral	-2.31	deleterious	-5.64	low_impact	1.71	0.35	damaging	0.32	neutral	2.89	21.80	deleterious	0.5	0.6	0.57	disease	0.65	disease	0.61	disease	0.37	neutral	3	0.54	neutral	0.48	deleterious	-3	neutral	0.67	deleterious	-0.82	medium_impact	0.21	medium_impact	0.5	medium_impact	0.74	0.85	67.4	19.84	0.71	P	0.85	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8093	8093	T	A	MI.6271	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	508	170	L	M	Tta/Ata	-12.85	0	0.01	probably_damaging	1	neutral	0.2	neutral	1.87	neutral	-2.1	neutral	-0.41	low_impact	1.09	0.57	damaging	0.31	neutral	3.72	23.30	deleterious	0.3	0.45	0.6	disease	0.36	neutral	0.18	neutral	0.61	disease	2	1	deleterious	0.1	neutral	-2	neutral	0.73	deleterious	-3.52	low_impact	-0.13	medium_impact	-0.08	medium_impact	0.80	0.85	55.07	18.46	0.47	N	0.78	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8093	8093	T	G	MI.6272	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	508	170	L	V	Tta/Gta	-12.85	0	0.01	probably_damaging	0.99	neutral	0.66	neutral	2.39	neutral	1.9	neutral	1.28	neutral_impact	-0.86	0.7	neutral	0.68	neutral	0.88	9.95	deleterious	0.35	0.5	0.35	neutral	0.03	neutral	0.14	neutral	0.22	neutral	6	0.99	deleterious	0.34	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.36	medium_impact	-1.91	low_impact	0.57	0.8	55.07	18.46	0.45	N	0.66	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8094	8094	T	G	MI.6273	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	509	170	L	W	tTa/tGa	-3.86	0	0	probably_damaging	1	deleterious	0.02	neutral	1.84	deleterious	-4.99	deleterious	-4.25	medium_impact	2.03	0.4	damaging	0.17	damaging	3.91	23.50	deleterious	0.21	0.45	0.9	disease	0.7	disease	0.56	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.85	deleterious	-3.52	low_impact	-0.73	medium_impact	0.8	medium_impact	0.55	0.8	55.07	18.46	0.44	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8094	8094	T	C	MI.6274	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	509	170	L	S	tTa/tCa	-3.86	0	0	probably_damaging	1	neutral	0.71	neutral	1.86	neutral	-2.53	deleterious	-3.36	medium_impact	2.46	0.47	damaging	0.16	damaging	3.92	23.50	deleterious	0.26	0.45	0.69	disease	0.58	disease	0.55	disease	0.66	disease	3	1	deleterious	0.36	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	0.42	medium_impact	1.2	medium_impact	0.52	0.8	55.07	18.46	0.26	N	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8095	8095	A	C	MI.6275	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	510	170	L	F	ttA/ttC	4.67	0.7	0	probably_damaging	1	neutral	0.05	neutral	1.87	neutral	-2.34	neutral	-2.26	low_impact	1.5	0.39	damaging	0.15	damaging	3.62	23.20	deleterious	0.34	0.5	0.69	disease	0.56	disease	0.53	disease	0.6	disease	2	1	deleterious	0.03	neutral	-2	neutral	0.80	deleterious	-3.52	low_impact	-0.5	medium_impact	0.3	medium_impact	0.59	0.8	55.07	18.46	0.64	P	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8095	8095	A	T	MI.6276	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	510	170	L	F	ttA/ttT	4.67	0.7	0	probably_damaging	1	neutral	0.05	neutral	1.87	neutral	-2.34	neutral	-2.26	low_impact	1.5	0.39	damaging	0.15	damaging	3.78	23.40	deleterious	0.34	0.5	0.69	disease	0.56	disease	0.53	disease	0.6	disease	2	1	deleterious	0.03	neutral	-2	neutral	0.80	deleterious	-3.52	low_impact	-0.5	medium_impact	0.3	medium_impact	0.59	0.8	55.07	18.46	0.64	P	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8096	8096	A	C	MI.6277	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	511	171	K	Q	Aaa/Caa	-2.01	0	0	probably_damaging	1	neutral	0.54	neutral	1.58	neutral	-2.83	deleterious	-3.93	high_impact	3.6	0.11	damaging	0.07	damaging	3.57	23.20	deleterious	0.38	0.5	0.7	disease	0.81	disease	0.76	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.24	medium_impact	2.27	high_impact	0.72	0.85	68.72	19.76	0.83	P	0.90	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8096	8096	A	G	MI.6278	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	511	171	K	E	Aaa/Gaa	-2.01	0	0	probably_damaging	1	neutral	0.9	neutral	1.54	deleterious	-3.76	deleterious	-3.93	high_impact	4.14	0.11	damaging	0.05	damaging	4.14	23.80	deleterious	0.34	0.5	0.85	disease	0.85	disease	0.76	disease	0.64	disease	3	1	deleterious	0.45	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.73	medium_impact	2.78	high_impact	0.73	0.85	68.72	19.76	0.73	P	0.95	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8097	8097	A	C	MI.6279	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	512	171	K	T	aAa/aCa	8.59	1	0	probably_damaging	1	neutral	0.57	neutral	1.48	deleterious	-4.2	deleterious	-5.88	high_impact	4.14	0.13	damaging	0.04	damaging	3.59	23.20	deleterious	0.24	0.45	0.61	disease	0.81	disease	0.75	disease	0.69	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.27	medium_impact	2.78	high_impact	0.47	0.8	68.72	19.76	0.86	P	0.88	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8822	8822	C	A	MI.628	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	296	99	S	Y	tCt/tAt	3.83	0.99	0	probably_damaging	1	neutral	0.47	neutral	3.8	neutral	-2.95	deleterious	-5.16	high_impact	4.12	0.6	neutral	0.45	neutral	4.05	23.70	deleterious	0.2	0.65	0.79	disease	0.79	disease	0.72	disease	0.71	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	0.26	medium_impact	2.43	high_impact	0.77	0.9	43.36	8.06	0.48	N	1.00	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8097	8097	A	T	MI.6280	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	512	171	K	M	aAa/aTa	8.59	1	0	probably_damaging	1	neutral	0.15	neutral	1.45	deleterious	-5.62	deleterious	-5.88	high_impact	4.7	0.14	damaging	0.04	damaging	3.86	23.50	deleterious	0.23	0.45	0.8	disease	0.82	disease	0.77	disease	0.67	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.21	medium_impact	3.3	high_impact	0.58	0.8	68.72	19.76	0.88	P	0.75	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8098	8098	A	C	MI.6281	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	513	171	K	N	aaA/aaC	8.59	1	0	probably_damaging	1	neutral	0.45	neutral	1.58	deleterious	-4.13	deleterious	-4.91	high_impact	4.7	0.11	damaging	0.04	damaging	3.93	23.50	deleterious	0.44	0.55	0.89	disease	0.83	disease	0.76	disease	0.62	disease	2	1	deleterious	0.23	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.16	medium_impact	3.3	high_impact	0.62	0.8	68.72	19.76	0.89	P	0.84	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8098	8098	A	T	MI.6282	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	513	171	K	N	aaA/aaT	8.59	1	0	probably_damaging	1	neutral	0.45	neutral	1.58	deleterious	-4.13	deleterious	-4.91	high_impact	4.7	0.11	damaging	0.04	damaging	3.97	23.60	deleterious	0.44	0.55	0.89	disease	0.83	disease	0.76	disease	0.62	disease	2	1	deleterious	0.23	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.16	medium_impact	3.3	high_impact	0.62	0.8	68.72	19.76	0.9	P	0.84	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8099	8099	A	T	MI.6283	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	514	172	T	S	Aca/Tca	4.67	1	0	probably_damaging	0.99	neutral	0.43	neutral	1.94	neutral	-0.78	deleterious	-2.56	medium_impact	2.22	0.47	damaging	0.17	damaging	1.83	15.16	deleterious	0.56	0.6	0.56	disease	0.34	neutral	0.43	neutral	0.59	disease	2	0.99	deleterious	0.22	neutral	1	deleterious	0.73	deleterious	-2.58	low_impact	0.14	medium_impact	0.98	medium_impact	0.77	0.85	70.93	17.12	0.64	P	0.63	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8099	8099	A	C	MI.6284	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	514	172	T	P	Aca/Cca	4.67	1	0	probably_damaging	1	neutral	0.22	neutral	1.89	neutral	-2.59	deleterious	-4.15	medium_impact	3.02	0.3	damaging	0.1	damaging	3.52	23.10	deleterious	0.16	0.45	0.78	disease	0.77	disease	0.41	neutral	0.53	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	-0.1	medium_impact	1.73	medium_impact	0.58	0.8	70.93	17.12	0.65	P	0.89	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8099	8099	A	G	MI.6285	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	514	172	T	A	Aca/Gca	4.67	1	0	probably_damaging	0.99	neutral	0.53	neutral	2.01	neutral	-0.13	deleterious	-2.92	neutral_impact	0.74	0.67	neutral	0.61	neutral	0.42	6.82	deleterious	0.71	0.75	0.47	neutral	0.15	neutral	0.23	neutral	0.26	neutral	5	0.99	deleterious	0.27	neutral	-2	neutral	0.70	deleterious	-2.58	low_impact	0.23	medium_impact	-0.41	medium_impact	0.31	0.8	70.93	17.12	0.43	N	0.44	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8100	8100	C	A	MI.6286	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	515	172	T	K	aCa/aAa	5.6	1	0	probably_damaging	1	neutral	0.32	neutral	1.91	neutral	0.26	deleterious	-3.9	low_impact	1.29	0.41	damaging	0.1	damaging	4.57	24.40	deleterious	0.32	0.5	0.29	neutral	0.64	disease	0.65	disease	0.69	disease	4	1	deleterious	0.16	neutral	-2	neutral	0.73	deleterious	-3.52	low_impact	0.02	medium_impact	0.1	medium_impact	0.65	0.8	70.93	17.12	0.63	P	0.88	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8100	8100	C	T	MI.6287	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	515	172	T	M	aCa/aTa	5.6	1	0	probably_damaging	1	neutral	0.27	neutral	2	neutral	0.82	neutral	-2.24	neutral_impact	-0.19	0.74	neutral	0.65	neutral	1.55	13.61	neutral	0.46	0.55	0.33	neutral	0.22	neutral	0.25	neutral	0.41	neutral	2	1	deleterious	0.14	neutral	-2	neutral	0.68	deleterious	-3.52	low_impact	-0.03	medium_impact	-1.28	low_impact	0.84	0.9	70.93	17.12	0.55	P	0.96	disease_causing	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8102	8102	G	A	MI.6288	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	517	173	D	N	Gat/Aat	-2.01	0	0	possibly_damaging	0.9	neutral	0.49	neutral	1.7	deleterious	-3.2	deleterious	-4.9	high_impact	4.36	0.28	damaging	0.2	damaging	4.27	23.90	deleterious	0.62	0.65	0.61	disease	0.84	disease	0.8	disease	0.69	disease	4	0.89	neutral	0.3	neutral	1	deleterious	0.81	deleterious	-1.61	low_impact	0.2	medium_impact	2.98	high_impact	0.77	0.85	68.28	19.89	0.85	P	0.99	disease_causing	0.79	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8102	8102	G	T	MI.6289	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	517	173	D	Y	Gat/Tat	-2.01	0	0	probably_damaging	1	deleterious	0.04	neutral	1.64	deleterious	-4.75	deleterious	-8.82	high_impact	3.66	0.28	damaging	0.15	damaging	4.08	23.70	deleterious	0.27	0.45	0.65	disease	0.93	disease	0.82	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.88	deleterious	-3.52	low_impact	-0.56	medium_impact	2.33	high_impact	0.45	0.8	68.28	19.89	0.79	P	0.99	disease_causing	0.98	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8822	8822	C	T	MI.629	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	296	99	S	F	tCt/tTt	3.83	0.99	0	probably_damaging	1	neutral	0.33	neutral	3.8	deleterious	-3.03	deleterious	-5.12	medium_impact	3.23	0.59	damaging	0.47	neutral	4.07	23.70	deleterious	0.2	0.65	0.78	disease	0.82	disease	0.72	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.12	medium_impact	1.67	medium_impact	0.49	0.9	43.36	8.06	0.44	N	1.00	disease_causing	1	0.12	.	.	.	.	.	.	COSM1331625	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8102	8102	G	C	MI.6290	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	517	173	D	H	Gat/Cat	-2.01	0	0	probably_damaging	1	neutral	0.12	neutral	1.65	deleterious	-5.17	deleterious	-6.86	high_impact	4.36	0.28	damaging	0.19	damaging	3.85	23.40	deleterious	0.32	0.5	0.94	disease	0.87	disease	0.83	disease	0.63	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.27	medium_impact	2.98	high_impact	0.49	0.8	68.28	19.89	0.86	P	0.98	disease_causing	0.95	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8103	8103	A	C	MI.6291	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	518	173	D	A	gAt/gCt	4.21	1	0	probably_damaging	0.95	neutral	0.8	neutral	1.71	deleterious	-3.7	deleterious	-7.84	high_impact	4.7	0.33	damaging	0.31	neutral	3.74	23.30	deleterious	0.24	0.45	0.88	disease	0.83	disease	0.78	disease	0.65	disease	3	0.94	neutral	0.43	neutral	2	deleterious	0.87	deleterious	-1.91	low_impact	0.54	medium_impact	3.3	high_impact	0.50	0.8	68.28	19.89	0.74	P	0.96	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8103	8103	A	G	MI.6292	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	518	173	D	G	gAt/gGt	4.21	1	0	benign	0.14	neutral	0.37	neutral	1.67	deleterious	-4.83	deleterious	-6.86	high_impact	4.36	0.3	damaging	0.28	neutral	2.14	17.13	deleterious	0.3	0.45	0.9	disease	0.85	disease	0.79	disease	0.64	disease	3	0.57	neutral	0.62	deleterious	-2	neutral	0.38	neutral	0.01	medium_impact	0.08	medium_impact	2.98	high_impact	0.47	0.8	68.28	19.89	0.74	P	0.97	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8103	8103	A	T	MI.6293	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	518	173	D	V	gAt/gTt	4.21	1	0	probably_damaging	1	neutral	0.33	neutral	1.66	deleterious	-4.81	deleterious	-8.82	high_impact	4.36	0.28	damaging	0.19	damaging	3.84	23.40	deleterious	0.22	0.45	0.95	disease	0.91	disease	0.8	disease	0.64	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.04	medium_impact	2.98	high_impact	0.30	0.8	68.28	19.89	0.86	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8104	8104	T	G	MI.6294	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	519	173	D	E	gaT/gaG	6.98	1	0	possibly_damaging	0.72	neutral	1	neutral	1.81	deleterious	-3.26	deleterious	-3.92	high_impact	4.15	0.31	damaging	0.16	damaging	3.82	23.40	deleterious	0.48	0.55	0.78	disease	0.81	disease	0.74	disease	0.69	disease	4	0.71	neutral	0.64	deleterious	1	deleterious	0.71	deleterious	-1.1	low_impact	1.86	high_impact	2.79	high_impact	0.65	0.8	68.28	19.89	0.75	P	0.95	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8104	8104	T	A	MI.6295	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	519	173	D	E	gaT/gaA	6.98	1	0	possibly_damaging	0.72	neutral	1	neutral	1.81	deleterious	-3.26	deleterious	-3.92	high_impact	4.15	0.31	damaging	0.16	damaging	3.96	23.60	deleterious	0.48	0.55	0.78	disease	0.81	disease	0.74	disease	0.69	disease	4	0.71	neutral	0.64	deleterious	1	deleterious	0.71	deleterious	-1.1	low_impact	1.86	high_impact	2.79	high_impact	0.65	0.8	68.28	19.89	0.76	P	0.95	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8105	8105	G	C	MI.6296	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	520	174	A	P	Gca/Cca	-6.86	0	0	probably_damaging	1	neutral	0.26	neutral	1.58	deleterious	-5.64	deleterious	-4.91	high_impact	4.48	0.19	damaging	0.02	damaging	4.02	23.60	deleterious	0.11	0.4	0.79	disease	0.87	disease	0.71	disease	0.7	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.05	medium_impact	3.1	high_impact	0.85	0.9	68.72	19.78	0.67	P	0.90	polymorphism	0.58	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8105	8105	G	A	MI.6297	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	520	174	A	T	Gca/Aca	-6.86	0	0	probably_damaging	1	neutral	0.42	neutral	1.64	neutral	-2.88	deleterious	-3.92	medium_impact	3.01	0.26	damaging	0.02	damaging	4.41	24.10	deleterious	0.42	0.5	0.34	neutral	0.79	disease	0.62	disease	0.65	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	0.13	medium_impact	1.72	medium_impact	0.71	0.85	68.72	19.78	0.63	P	0.72	polymorphism	0.83	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8105	8105	G	T	MI.6298	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	520	174	A	S	Gca/Tca	-6.86	0	0	probably_damaging	1	neutral	0.46	neutral	1.63	deleterious	-3.82	deleterious	-2.94	medium_impact	2.28	0.31	damaging	0.03	damaging	3.87	23.50	deleterious	0.32	0.5	0.75	disease	0.79	disease	0.6	disease	0.55	disease	1	1	deleterious	0.23	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	0.17	medium_impact	1.03	medium_impact	0.87	0.9	68.72	19.78	0.45	N	0.71	polymorphism	0.92	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8106	8106	C	T	MI.6299	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	521	174	A	V	gCa/gTa	6.06	1	0	probably_damaging	1	neutral	0.59	neutral	1.83	neutral	-1.58	deleterious	-3.93	medium_impact	2.98	0.24	damaging	0.01	damaging	4.60	24.40	deleterious	0.39	0.5	0.51	disease	0.8	disease	0.72	disease	0.67	disease	3	1	deleterious	0.3	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	0.29	medium_impact	1.69	medium_impact	0.68	0.85	68.72	19.78	0.84	P	0.79	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8554	8554	A	G	MI.63	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	28	10	I	V	Att/Gtt	-0.33	0	0	benign	0	neutral	0.07	neutral	4.7	neutral	0.02	neutral	0.18	low_impact	1.43	0.95	neutral	0.83	neutral	0.53	7.68	deleterious	0.47	0.65	0.48	neutral	0.2	neutral	0.35	neutral	0.34	neutral	3	0.93	neutral	0.54	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	-0.34	medium_impact	0.13	medium_impact	0.24	0.9	27.43	16.7	0.46	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8824	8824	A	G	MI.630	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	298	100	M	V	Ata/Gta	-15.14	0	0	possibly_damaging	0.87	neutral	0.52	neutral	4.55	neutral	1.8	neutral	-2.31	neutral_impact	0.18	0.9	neutral	0.59	neutral	2.61	20.30	deleterious	0.57	0.65	0.26	neutral	0.55	disease	0.53	disease	0.36	neutral	3	0.86	neutral	0.33	neutral	-3	neutral	0.55	deleterious	-1.54	low_impact	0.31	medium_impact	-0.94	medium_impact	0.66	0.9	27.43	8.87	0.33	N	0.95	polymorphism	0.81	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8106	8106	C	A	MI.6300	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	521	174	A	E	gCa/gAa	6.06	1	0	probably_damaging	1	neutral	0.32	neutral	1.59	deleterious	-5.14	deleterious	-4.91	high_impact	4.48	0.23	damaging	0.03	damaging	4.58	24.40	deleterious	0.12	0.4	0.86	disease	0.88	disease	0.77	disease	0.68	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.02	medium_impact	3.1	high_impact	0.75	0.85	68.72	19.78	0.85	P	0.91	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8106	8106	C	G	MI.6301	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	521	174	A	G	gCa/gGa	6.06	1	0	probably_damaging	0.99	neutral	0.41	neutral	1.6	deleterious	-4.95	deleterious	-3.91	medium_impact	2.78	0.38	damaging	0.17	damaging	4.05	23.70	deleterious	0.25	0.45	0.81	disease	0.43	neutral	0.45	neutral	0.56	disease	1	0.99	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	0.12	medium_impact	1.5	medium_impact	0.86	0.9	68.72	19.78	0.71	P	0.74	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8108	8108	A	G	MI.6302	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	523	175	I	V	Att/Gtt	-8.93	0	0	benign	0.01	neutral	0.35	neutral	1.98	neutral	0.2	neutral	-0.04	neutral_impact	0.02	0.87	neutral	0.87	neutral	-1.44	0.00	neutral	0.53	0.6	0.32	neutral	0.12	neutral	0.27	neutral	0.22	neutral	6	0.64	neutral	0.67	deleterious	-6	neutral	0.12	neutral	1.14	medium_impact	0.06	medium_impact	-1.09	low_impact	0.58	0.8	71.37	11.62	0.44	N	0.19	polymorphism	1	0.00	.	.	.	.	.	MNGIE fibroblasts	.	.	.	A8108G	SNHL	+	-	Reported	1	.	P	P	neutral
chrM	8108	8108	A	C	MI.6303	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	523	175	I	L	Att/Ctt	-8.93	0	0	benign	0.16	neutral	0.34	neutral	1.89	neutral	-1.55	neutral	-1.96	medium_impact	2.21	0.57	damaging	0.35	neutral	2.18	17.39	deleterious	0.37	0.5	0.57	disease	0.52	disease	0.62	disease	0.67	disease	3	0.6	neutral	0.59	deleterious	-3	neutral	0.25	neutral	-0.05	medium_impact	0.05	medium_impact	0.97	medium_impact	0.83	0.9	71.37	11.62	0.32	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8108	8108	A	T	MI.6304	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	523	175	I	F	Att/Ttt	-8.93	0	0	possibly_damaging	0.74	neutral	0.06	neutral	1.83	neutral	-2.63	deleterious	-3.92	medium_impact	2.86	0.52	damaging	0.28	neutral	4.06	23.70	deleterious	0.31	0.45	0.75	disease	0.69	disease	0.68	disease	0.7	disease	4	0.95	neutral	0.16	neutral	0	NA	0.75	deleterious	-1.14	low_impact	-0.46	medium_impact	1.58	medium_impact	0.80	0.85	71.37	11.62	0.31	N	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8109	8109	T	C	MI.6305	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	524	175	I	T	aTt/aCt	1.91	0.94	0	probably_damaging	0.96	neutral	0.58	neutral	1.86	neutral	-2.58	deleterious	-3.97	low_impact	1.57	0.62	neutral	0.35	neutral	2.19	17.44	deleterious	0.37	0.5	0.62	disease	0.12	neutral	0.36	neutral	0.32	neutral	4	0.95	neutral	0.31	neutral	-2	neutral	0.63	deleterious	-2.01	low_impact	0.28	medium_impact	0.37	medium_impact	0.72	0.85	71.37	11.62	0.33	N	0.94	polymorphism	0.81	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8109	8109	T	G	MI.6306	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	524	175	I	S	aTt/aGt	1.91	0.94	0	probably_damaging	0.99	neutral	0.73	neutral	1.83	deleterious	-3.2	deleterious	-5.42	medium_impact	2.67	0.55	damaging	0.37	neutral	4.46	24.20	deleterious	0.25	0.45	0.72	disease	0.75	disease	0.67	disease	0.6	disease	2	0.98	deleterious	0.37	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	0.44	medium_impact	1.4	medium_impact	0.56	0.8	71.37	11.62	0.3	N	0.92	polymorphism	0.52	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8109	8109	T	A	MI.6307	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	524	175	I	N	aTt/aAt	1.91	0.94	0	probably_damaging	1	neutral	0.5	neutral	1.83	neutral	-2.58	deleterious	-6.4	medium_impact	2.23	0.54	damaging	0.3	neutral	4.71	24.60	deleterious	0.27	0.45	0.48	neutral	0.82	disease	0.57	disease	0.46	neutral	1	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.21	medium_impact	0.99	medium_impact	0.58	0.8	71.37	11.62	0.32	N	0.98	polymorphism	0.58	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8110	8110	T	G	MI.6308	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	525	175	I	M	atT/atG	4.67	0.98	0	possibly_damaging	0.9	neutral	0.12	neutral	1.89	neutral	-1.66	neutral	-2.48	medium_impact	2.18	0.58	damaging	0.35	neutral	3.59	23.20	deleterious	0.41	0.5	0.39	neutral	0.51	disease	0.53	disease	0.48	neutral	0	0.96	neutral	0.11	neutral	0	NA	0.51	deleterious	-1.61	low_impact	-0.27	medium_impact	0.94	medium_impact	0.84	0.9	71.37	11.62	0.54	P	0.79	polymorphism	0.55	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8110	8110	T	A	MI.6309	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	525	175	I	M	atT/atA	4.67	0.98	0	possibly_damaging	0.9	neutral	0.12	neutral	1.89	neutral	-1.66	neutral	-2.48	medium_impact	2.18	0.58	damaging	0.35	neutral	3.86	23.50	deleterious	0.41	0.5	0.39	neutral	0.51	disease	0.53	disease	0.48	neutral	0	0.96	neutral	0.11	neutral	0	NA	0.51	deleterious	-1.61	low_impact	-0.27	medium_impact	0.94	medium_impact	0.84	0.9	71.37	11.62	0.58	P	0.79	polymorphism	0.55	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8824	8824	A	T	MI.631	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	298	100	M	L	Ata/Tta	-15.14	0	0	possibly_damaging	0.81	neutral	0.99	neutral	4.61	neutral	1.09	neutral	-1.09	neutral_impact	-0.04	0.87	neutral	0.9	neutral	1.33	12.43	neutral	0.51	0.65	0.27	neutral	0.3	neutral	0.42	neutral	0.43	neutral	1	0.81	neutral	0.59	deleterious	-3	neutral	0.49	deleterious	-1.35	low_impact	1.42	medium_impact	-1.13	low_impact	0.65	0.9	27.43	8.87	0.28	N	0.93	polymorphism	0.84	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8111	8111	C	G	MI.6310	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	526	176	P	A	Ccc/Gcc	-6.63	0	0	probably_damaging	1	neutral	0.8	neutral	-0.07	deleterious	-5.81	deleterious	-7.85	high_impact	4.33	0.15	damaging	0.11	damaging	3.26	22.80	deleterious	0.17	0.45	0.51	disease	0.64	disease	0.71	disease	0.66	disease	3	1	deleterious	0.4	neutral	2	deleterious	0.77	deleterious	-3.52	low_impact	0.54	medium_impact	2.95	high_impact	0.68	0.85	68.28	19.64	0.57	P	0.90	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8111	8111	C	T	MI.6311	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	526	176	P	S	Ccc/Tcc	-6.63	0	0	probably_damaging	1	neutral	0.76	neutral	-0.12	deleterious	-7.03	deleterious	-7.85	medium_impact	3.32	0.11	damaging	0.03	damaging	4.05	23.70	deleterious	0.22	0.45	0.76	disease	0.82	disease	0.71	disease	0.68	disease	4	1	deleterious	0.38	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	0.48	medium_impact	2.01	high_impact	0.33	0.8	68.28	19.64	0.5	P	0.94	polymorphism	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8111	8111	C	A	MI.6312	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	526	176	P	T	Ccc/Acc	-6.63	0	0	probably_damaging	1	neutral	0.59	neutral	-0.13	deleterious	-7.38	deleterious	-7.85	high_impact	3.87	0.11	damaging	0.02	damaging	3.84	23.40	deleterious	0.18	0.45	0.57	disease	0.8	disease	0.71	disease	0.68	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	0.29	medium_impact	2.52	high_impact	0.66	0.8	68.28	19.64	0.51	P	0.96	polymorphism	0.99	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8112	8112	C	T	MI.6313	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	527	176	P	L	cCc/cTc	7.21	1	0	probably_damaging	1	neutral	0.42	neutral	-0.14	deleterious	-7.76	deleterious	-9.82	high_impact	4.33	0.09	damaging	0.02	damaging	4.54	24.30	deleterious	0.18	0.45	0.94	disease	0.85	disease	0.69	disease	0.61	disease	2	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.13	medium_impact	2.95	high_impact	0.72	0.85	68.28	19.64	0.76	P	0.92	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8112	8112	C	A	MI.6314	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	527	176	P	H	cCc/cAc	7.21	1	0	probably_damaging	1	neutral	0.16	neutral	-0.15	deleterious	-10.03	deleterious	-8.84	high_impact	4.33	0.09	damaging	0.02	damaging	4.12	23.80	deleterious	0.15	0.45	0.96	disease	0.85	disease	0.77	disease	0.62	disease	2	1	deleterious	0.08	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.19	medium_impact	2.95	high_impact	0.61	0.8	68.28	19.64	0.78	P	0.79	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8112	8112	C	G	MI.6315	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	527	176	P	R	cCc/cGc	7.21	1	0	probably_damaging	1	neutral	0.56	neutral	-0.15	deleterious	-8.74	deleterious	-8.84	high_impact	4.33	0.12	damaging	0.02	damaging	3.73	23.30	deleterious	0.14	0.4	0.93	disease	0.88	disease	0.78	disease	0.63	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.26	medium_impact	2.95	high_impact	0.60	0.8	68.28	19.64	0.72	P	0.85	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8114	8114	G	C	MI.6316	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	529	177	G	R	Gga/Cga	-4.09	0	0	probably_damaging	1	neutral	0.42	neutral	1.35	deleterious	-4.52	deleterious	-7.85	high_impact	4.32	0.28	damaging	0.1	damaging	4.11	23.70	deleterious	0.14	0.4	0.86	disease	0.9	disease	0.84	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.13	medium_impact	2.95	high_impact	0.66	0.8	69.16	20.04	0.7	P	1.00	polymorphism	0.97	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8114	8114	G	T	MI.6317	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	529	177	G	W	Gga/Tga	-4.09	0	0	probably_damaging	1	neutral	0.18	neutral	1.31	deleterious	-8.42	deleterious	-7.85	high_impact	4.67	0.3	damaging	0.1	damaging	4.58	24.40	deleterious	0.12	0.4	0.99	disease	0.9	disease	0.8	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.16	medium_impact	3.27	high_impact	0.37	0.8	69.16	20.04	0.56	P	0.98	polymorphism	0.96	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8115	8115	G	C	MI.6318	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	530	177	G	A	gGa/gCa	9.29	1	0	probably_damaging	1	neutral	0.55	neutral	1.36	deleterious	-4.13	deleterious	-5.89	high_impact	3.98	0.31	damaging	0.28	damaging	3.27	22.80	deleterious	0.21	0.45	0.62	disease	0.72	disease	0.74	disease	0.69	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.25	medium_impact	2.63	high_impact	0.70	0.85	69.16	20.04	0.79	P	0.85	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8115	8115	G	T	MI.6319	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	530	177	G	V	gGa/gTa	9.29	1	0	probably_damaging	1	neutral	0.54	neutral	1.32	deleterious	-5.37	deleterious	-8.83	high_impact	4.32	0.28	damaging	0.13	damaging	3.91	23.50	deleterious	0.12	0.4	0.93	disease	0.88	disease	0.76	disease	0.61	disease	2	1	deleterious	0.27	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.24	medium_impact	2.95	high_impact	0.52	0.8	69.16	20.04	0.8	P	1.00	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8824	8824	A	C	MI.632	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	298	100	M	L	Ata/Cta	-15.14	0	0	possibly_damaging	0.81	neutral	0.99	neutral	4.61	neutral	1.09	neutral	-1.09	neutral_impact	-0.04	0.87	neutral	0.9	neutral	1.19	11.71	neutral	0.51	0.65	0.27	neutral	0.3	neutral	0.42	neutral	0.43	neutral	1	0.81	neutral	0.59	deleterious	-3	neutral	0.49	deleterious	-1.35	low_impact	1.42	medium_impact	-1.13	low_impact	0.65	0.9	27.43	8.87	0.28	N	0.93	polymorphism	0.84	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8115	8115	G	A	MI.6320	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	530	177	G	E	gGa/gAa	9.29	1	0	probably_damaging	1	neutral	0.27	neutral	1.39	deleterious	-3.49	deleterious	-7.85	high_impact	4.67	0.32	damaging	0.11	damaging	4.01	23.60	deleterious	0.15	0.45	0.76	disease	0.89	disease	0.82	disease	0.72	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.03	medium_impact	3.27	high_impact	0.66	0.8	69.16	20.04	0.8	P	1.00	disease_causing	1	0.22	.	.	.	.	.	.	COSM218997	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8117	8117	C	A	MI.6321	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	532	178	R	S	Cgt/Agt	-7.32	0	0	probably_damaging	1	neutral	0.84	neutral	1.8	neutral	-1.77	deleterious	-5.88	high_impact	3.87	0.12	damaging	0.01	damaging	4.72	24.60	deleterious	0.3	0.45	0.72	disease	0.84	disease	0.68	disease	0.69	disease	4	1	deleterious	0.42	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.6	medium_impact	2.52	high_impact	0.43	0.8	67.84	20.05	0.68	P	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8117	8117	C	T	MI.6322	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	532	178	R	C	Cgt/Tgt	-7.32	0	0	probably_damaging	1	neutral	0.1	neutral	1.72	deleterious	-4.96	deleterious	-7.84	high_impact	4.57	0.14	damaging	0	damaging	5.18	25.50	deleterious	0.36	0.5	0.96	disease	0.87	disease	0.71	disease	0.61	disease	2	1	deleterious	0.05	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.32	medium_impact	3.18	high_impact	0.73	0.85	67.84	20.05	0.68	P	1.00	disease_causing	0.57	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8117	8117	C	G	MI.6323	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	532	178	R	G	Cgt/Ggt	-7.32	0	0	probably_damaging	1	neutral	0.51	neutral	1.75	neutral	-2.93	deleterious	-6.86	high_impact	4.22	0.15	damaging	0	damaging	4.33	24.00	deleterious	0.31	0.5	0.84	disease	0.78	disease	0.68	disease	0.66	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.21	medium_impact	2.85	high_impact	0.38	0.8	67.84	20.05	0.59	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8118	8118	G	C	MI.6324	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	533	178	R	P	cGt/cCt	3.52	0.99	0	probably_damaging	1	neutral	0.33	neutral	1.74	deleterious	-3.5	deleterious	-6.86	high_impact	4.57	0.14	damaging	0.01	damaging	4.36	24.10	deleterious	0.22	0.45	0.88	disease	0.87	disease	0.7	disease	0.62	disease	2	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.04	medium_impact	3.18	high_impact	0.31	0.8	67.84	20.05	0.83	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8118	8118	G	A	MI.6325	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	533	178	R	H	cGt/cAt	3.52	0.99	0	probably_damaging	1	neutral	0.28	neutral	1.74	deleterious	-3.16	deleterious	-4.9	medium_impact	3.37	0.14	damaging	0	damaging	4.56	24.40	deleterious	0.44	0.55	0.78	disease	0.8	disease	0.65	disease	0.67	disease	3	1	deleterious	0.14	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	-0.02	medium_impact	2.05	high_impact	0.77	0.85	67.84	20.05	0.88	P	0.99	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8118	8118	G	T	MI.6326	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	533	178	R	L	cGt/cTt	3.52	0.99	0	probably_damaging	1	neutral	0.58	neutral	1.77	neutral	-2.38	deleterious	-6.86	medium_impact	3.12	0.13	damaging	0.01	damaging	4.43	24.20	deleterious	0.32	0.5	0.83	disease	0.89	disease	0.67	disease	0.65	disease	3	0.99	deleterious	0.29	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	0.28	medium_impact	1.82	medium_impact	0.32	0.8	67.84	20.05	0.85	P	1.00	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8120	8120	C	A	MI.6327	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	535	179	L	M	Cta/Ata	-6.86	0	0	probably_damaging	1	neutral	0.24	neutral	1.7	neutral	-2.92	neutral	-1.93	medium_impact	2.9	0.24	damaging	0.06	damaging	3.88	23.50	deleterious	0.36	0.5	0.73	disease	0.6	disease	0.48	neutral	0.39	neutral	2	1	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	-0.07	medium_impact	1.61	medium_impact	0.80	0.85	68.28	19.75	0.63	P	0.78	polymorphism	1	0.02	rs8936	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8120	8120	C	G	MI.6328	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	535	179	L	V	Cta/Gta	-6.86	0	0	probably_damaging	0.99	neutral	0.53	neutral	1.86	neutral	-0.82	deleterious	-2.91	medium_impact	2.06	0.18	damaging	0.01	damaging	3.55	23.10	deleterious	0.4	0.5	0.44	neutral	0.6	disease	0.51	disease	0.52	disease	0	0.99	deleterious	0.27	neutral	1	deleterious	0.76	deleterious	-2.58	low_impact	0.23	medium_impact	0.83	medium_impact	0.64	0.8	68.28	19.75	0.67	P	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8121	8121	T	A	MI.6329	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	536	179	L	Q	cTa/cAa	-1.09	0	0	probably_damaging	1	neutral	0.32	neutral	1.69	deleterious	-3.38	deleterious	-5.84	high_impact	3.65	0.2	damaging	0.02	damaging	4.13	23.80	deleterious	0.26	0.45	0.81	disease	0.85	disease	0.63	disease	0.66	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.02	medium_impact	2.32	high_impact	0.52	0.8	68.28	19.75	0.74	P	0.95	disease_causing	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8825	8825	T	A	MI.633	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	299	100	M	K	aTa/aAa	0.82	0.08	0	probably_damaging	0.94	deleterious	0	neutral	4.34	neutral	-2.19	deleterious	-4.62	medium_impact	3.34	0.75	neutral	0.09	damaging	3.81	23.40	deleterious	0.15	0.65	0.72	disease	0.82	disease	0.73	disease	0.75	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.81	deleterious	-1.89	low_impact	-1.4	low_impact	1.77	medium_impact	0.62	0.9	27.43	8.87	0.32	N	0.98	disease_causing	0.91	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8121	8121	T	C	MI.6330	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	536	179	L	P	cTa/cCa	-1.09	0	0	probably_damaging	1	neutral	0.22	neutral	1.67	deleterious	-4.22	deleterious	-6.82	high_impact	3.54	0.16	damaging	0.01	damaging	4.00	23.60	deleterious	0.21	0.45	0.86	disease	0.83	disease	0.63	disease	0.63	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.1	medium_impact	2.21	high_impact	0.45	0.8	68.28	19.75	0.72	P	0.99	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8121	8121	T	G	MI.6331	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	536	179	L	R	cTa/cGa	-1.09	0	0	probably_damaging	1	neutral	0.39	neutral	1.69	deleterious	-3.37	deleterious	-5.84	medium_impact	3.46	0.17	damaging	0.01	damaging	4.26	23.90	deleterious	0.25	0.45	0.8	disease	0.87	disease	0.75	disease	0.69	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.89	deleterious	-3.52	low_impact	0.1	medium_impact	2.14	high_impact	0.49	0.8	68.28	19.75	0.76	P	0.99	disease_causing	0.98	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8123	8123	A	T	MI.6332	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	538	180	N	Y	Aac/Tac	-2.24	0	0	probably_damaging	1	neutral	0.22	neutral	1.71	deleterious	-4.79	deleterious	-7.8	high_impact	4.26	0.14	damaging	0.05	damaging	3.86	23.50	deleterious	0.35	0.5	0.85	disease	0.78	disease	0.75	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	-0.1	medium_impact	2.89	high_impact	0.47	0.8	68.28	19.58	0.76	P	0.98	disease_causing	0.51	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8123	8123	A	G	MI.6333	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	538	180	N	D	Aac/Gac	-2.24	0	0	probably_damaging	0.99	neutral	0.66	neutral	1.78	deleterious	-3.14	deleterious	-4.87	high_impact	4.06	0.19	damaging	0.05	damaging	3.98	23.60	deleterious	0.53	0.6	0.78	disease	0.64	disease	0.74	disease	0.67	disease	3	0.99	deleterious	0.34	neutral	2	deleterious	0.78	deleterious	-2.58	low_impact	0.36	medium_impact	2.7	high_impact	0.55	0.8	68.28	19.58	0.73	P	0.97	polymorphism	0.89	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8123	8123	A	C	MI.6334	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	538	180	N	H	Aac/Cac	-2.24	0	0	probably_damaging	1	neutral	0.21	neutral	1.72	deleterious	-4.07	deleterious	-4.87	high_impact	3.92	0.13	damaging	0.05	damaging	3.23	22.80	deleterious	0.43	0.55	0.77	disease	0.68	disease	0.76	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	-0.11	medium_impact	2.57	high_impact	0.44	0.8	68.28	19.58	0.8	P	0.94	polymorphism	0.8	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8124	8124	A	G	MI.6335	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	539	180	N	S	aAc/aGc	6.98	1	0	probably_damaging	0.98	neutral	0.85	neutral	1.8	neutral	-2.22	deleterious	-4.84	medium_impact	2.96	0.16	damaging	0.05	damaging	3.12	22.60	deleterious	0.58	0.65	0.64	disease	0.7	disease	0.64	disease	0.65	disease	3	0.98	deleterious	0.44	neutral	1	deleterious	0.79	deleterious	-2.3	low_impact	0.62	medium_impact	1.67	medium_impact	0.35	0.8	68.28	19.58	0.83	P	0.87	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8124	8124	A	T	MI.6336	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	539	180	N	I	aAc/aTc	6.98	1	0	probably_damaging	1	neutral	0.31	neutral	1.72	deleterious	-3.78	deleterious	-8.78	high_impact	3.92	0.16	damaging	0.02	damaging	3.96	23.60	deleterious	0.37	0.5	0.75	disease	0.77	disease	0.71	disease	0.68	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	0.01	medium_impact	2.57	high_impact	0.40	0.8	68.28	19.58	0.83	P	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8124	8124	A	C	MI.6337	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	539	180	N	T	aAc/aCc	6.98	1	0	probably_damaging	1	neutral	0.64	neutral	1.76	neutral	-1.12	deleterious	-5.83	medium_impact	2.96	0.13	damaging	0.03	damaging	3.48	23.10	deleterious	0.51	0.6	0.38	neutral	0.71	disease	0.63	disease	0.65	disease	3	1	deleterious	0.32	neutral	1	deleterious	0.73	deleterious	-3.52	low_impact	0.34	medium_impact	1.67	medium_impact	0.64	0.8	68.28	19.58	0.84	P	0.92	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8125	8125	C	G	MI.6338	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	540	180	N	K	aaC/aaG	8.59	1	0	probably_damaging	1	neutral	0.93	neutral	1.79	neutral	-2.3	deleterious	-5.84	high_impact	4.26	0.13	damaging	0.02	damaging	4.18	23.80	deleterious	0.59	0.65	0.68	disease	0.74	disease	0.73	disease	0.68	disease	4	1	deleterious	0.47	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.83	medium_impact	2.89	high_impact	0.58	0.8	68.28	19.58	0.8	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8125	8125	C	A	MI.6339	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	540	180	N	K	aaC/aaA	8.59	1	0	probably_damaging	1	neutral	0.93	neutral	1.79	neutral	-2.3	deleterious	-5.84	high_impact	4.26	0.13	damaging	0.02	damaging	4.62	24.50	deleterious	0.59	0.65	0.68	disease	0.74	disease	0.73	disease	0.68	disease	4	1	deleterious	0.47	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.83	medium_impact	2.89	high_impact	0.58	0.8	68.28	19.58	0.8	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8825	8825	T	C	MI.634	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	299	100	M	T	aTa/aCa	0.82	0.08	0	probably_damaging	0.94	deleterious	0.03	neutral	4.43	neutral	0.35	deleterious	-4.19	medium_impact	2.24	0.87	neutral	0.49	neutral	1.78	14.87	neutral	0.37	0.65	0.28	neutral	0.67	disease	0.54	disease	0.41	neutral	2	0.99	deleterious	0.05	neutral	5	deleterious	0.68	deleterious	-1.89	low_impact	-0.56	medium_impact	0.82	medium_impact	0.52	0.9	27.43	8.87	0.46	N	0.97	disease_causing	0.57	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8126	8126	C	A	MI.6340	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	541	181	Q	K	Caa/Aaa	-2.48	0	0	probably_damaging	0.98	neutral	0.3	neutral	1.89	neutral	-0.33	deleterious	-3.92	medium_impact	2.9	0.16	damaging	0.02	damaging	4.20	23.90	deleterious	0.54	0.6	0.33	neutral	0.77	disease	0.69	disease	0.66	disease	3	0.98	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-2.3	low_impact	0	medium_impact	1.61	medium_impact	0.62	0.8	69.16	19.48	0.76	P	0.97	polymorphism	0.74	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8126	8126	C	G	MI.6341	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	541	181	Q	E	Caa/Gaa	-2.48	0	0	probably_damaging	0.95	neutral	0.28	neutral	1.88	neutral	0.5	deleterious	-2.93	low_impact	1.84	0.16	damaging	0.04	damaging	3.21	22.70	deleterious	0.5	0.6	0.45	neutral	0.64	disease	0.68	disease	0.65	disease	3	0.96	neutral	0.17	neutral	-2	neutral	0.75	deleterious	-1.91	low_impact	-0.02	medium_impact	0.62	medium_impact	0.63	0.8	69.16	19.48	0.77	P	0.85	polymorphism	0.86	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8127	8127	A	G	MI.6342	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	542	181	Q	R	cAa/cGa	7.21	1	0	probably_damaging	0.98	neutral	0.35	neutral	1.85	neutral	-1.15	deleterious	-3.92	medium_impact	2.41	0.15	damaging	0.03	damaging	3.63	23.20	deleterious	0.53	0.6	0.47	neutral	0.75	disease	0.71	disease	0.67	disease	3	0.99	deleterious	0.19	neutral	1	deleterious	0.79	deleterious	-2.3	low_impact	0.06	medium_impact	1.15	medium_impact	0.59	0.8	69.16	19.48	0.88	P	0.95	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8127	8127	A	C	MI.6343	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	542	181	Q	P	cAa/cCa	7.21	1	0	probably_damaging	0.99	neutral	0.21	neutral	1.77	neutral	-2.33	deleterious	-5.88	high_impact	4.19	0.16	damaging	0.03	damaging	3.48	23.10	deleterious	0.2	0.45	0.79	disease	0.78	disease	0.67	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-2.58	low_impact	-0.11	medium_impact	2.82	high_impact	0.36	0.8	69.16	19.48	0.86	P	0.95	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8127	8127	A	T	MI.6344	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	542	181	Q	L	cAa/cTa	7.21	1	0	probably_damaging	0.98	neutral	0.66	neutral	1.79	neutral	-2.5	deleterious	-6.86	medium_impact	2.81	0.13	damaging	0.03	damaging	3.95	23.60	deleterious	0.32	0.5	0.67	disease	0.77	disease	0.66	disease	0.66	disease	3	0.97	neutral	0.34	neutral	1	deleterious	0.80	deleterious	-2.3	low_impact	0.36	medium_impact	1.53	medium_impact	0.28	0.8	69.16	19.48	0.84	P	0.97	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8128	8128	A	T	MI.6345	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	543	181	Q	H	caA/caT	8.59	1	0	probably_damaging	1	neutral	0.54	neutral	1.77	neutral	-1.81	deleterious	-4.9	medium_impact	2.75	0.12	damaging	0.03	damaging	3.68	23.30	deleterious	0.48	0.55	0.39	neutral	0.69	disease	0.71	disease	0.67	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	0.24	medium_impact	1.47	medium_impact	0.68	0.85	69.16	19.48	0.88	P	0.86	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8128	8128	A	C	MI.6346	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	543	181	Q	H	caA/caC	8.59	1	0	probably_damaging	1	neutral	0.54	neutral	1.77	neutral	-1.81	deleterious	-4.9	medium_impact	2.75	0.12	damaging	0.03	damaging	3.46	23.00	deleterious	0.48	0.55	0.39	neutral	0.69	disease	0.71	disease	0.67	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	0.24	medium_impact	1.47	medium_impact	0.68	0.85	69.16	19.48	0.88	P	0.86	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8129	8129	A	G	MI.6347	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	544	182	T	A	Acc/Gcc	3.29	1	0	benign	0.01	neutral	0.78	neutral	1.98	neutral	-0.66	deleterious	-2.9	neutral_impact	0.02	0.75	neutral	0.97	neutral	0.19	4.54	deleterious	0.55	0.6	0.43	neutral	0.22	neutral	0.29	neutral	0.38	neutral	2	0.2	neutral	0.89	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.51	medium_impact	-1.09	low_impact	0.51	0.8	24.67	43.28	0.44	N	0.00	disease_causing	0.76	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8129	8129	A	C	MI.6348	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	544	182	T	P	Acc/Ccc	3.29	1	0	possibly_damaging	0.66	neutral	0.31	neutral	1.88	deleterious	-3.92	deleterious	-4.67	medium_impact	2.64	0.42	damaging	0.29	neutral	3.37	22.90	deleterious	0.15	0.4	0.38	neutral	0.78	disease	0.56	disease	0.62	disease	2	0.74	neutral	0.33	neutral	0	NA	0.61	deleterious	-0.99	medium_impact	0.01	medium_impact	1.37	medium_impact	0.65	0.8	24.67	43.28	0.57	P	0.74	disease_causing	0.94	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8129	8129	A	T	MI.6349	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	544	182	T	S	Acc/Tcc	3.29	1	0	benign	0.12	neutral	0.83	neutral	1.93	neutral	-1.81	deleterious	-2.73	neutral_impact	0.78	0.6	damaging	0.63	neutral	1.43	12.97	neutral	0.44	0.55	0.57	disease	0.43	neutral	0.27	neutral	0.57	disease	1	0.07	neutral	0.86	deleterious	-6	neutral	0.24	neutral	0.09	medium_impact	0.59	medium_impact	-0.37	medium_impact	0.70	0.85	24.67	43.28	0.36	N	0.29	disease_causing	0.51	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8826	8826	A	C	MI.635	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	300	100	M	I	atA/atC	3.83	0.49	0	probably_damaging	0.91	neutral	0.55	neutral	4.51	neutral	1.04	neutral	-2.05	low_impact	0.88	0.84	neutral	0.18	damaging	2.10	16.87	deleterious	0.53	0.65	0.37	neutral	0.61	disease	0.47	neutral	0.34	neutral	3	0.9	neutral	0.32	neutral	-2	neutral	0.63	deleterious	-1.71	low_impact	0.34	medium_impact	-0.34	medium_impact	0.78	0.9	27.43	8.87	0.26	N	0.91	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8130	8130	C	T	MI.6350	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	545	182	T	I	aCc/aTc	0.98	0.98	0	possibly_damaging	0.61	neutral	0.22	neutral	2.05	neutral	-0.51	deleterious	-4.38	neutral_impact	0.53	0.63	neutral	0.71	neutral	2.62	20.30	deleterious	0.34	0.5	0.34	neutral	0.46	neutral	0.26	neutral	0.41	neutral	2	0.79	neutral	0.31	neutral	-3	neutral	0.50	deleterious	-0.9	medium_impact	-0.1	medium_impact	-0.61	medium_impact	0.61	0.8	24.67	43.28	0.46	N	0.38	polymorphism	0.96	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8130	8130	C	G	MI.6351	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	545	182	T	S	aCc/aGc	0.98	0.98	0	benign	0.12	neutral	0.83	neutral	1.93	neutral	-1.81	deleterious	-2.73	neutral_impact	0.78	0.6	damaging	0.63	neutral	1.76	14.75	neutral	0.44	0.55	0.57	disease	0.43	neutral	0.27	neutral	0.57	disease	1	0.07	neutral	0.86	deleterious	-6	neutral	0.24	neutral	0.09	medium_impact	0.59	medium_impact	-0.37	medium_impact	0.70	0.85	24.67	43.28	0.37	N	0.29	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8130	8130	C	A	MI.6352	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	545	182	T	N	aCc/aAc	0.98	0.98	0	possibly_damaging	0.66	neutral	0.51	neutral	1.89	neutral	-2.45	deleterious	-4.11	medium_impact	2.3	0.53	damaging	0.42	neutral	3.67	23.20	deleterious	0.33	0.5	0.73	disease	0.69	disease	0.58	disease	0.63	disease	3	0.63	neutral	0.43	neutral	0	NA	0.56	deleterious	-0.99	medium_impact	0.21	medium_impact	1.05	medium_impact	0.73	0.85	24.67	43.28	0.44	N	0.59	polymorphism	0.96	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8132	8132	A	T	MI.6353	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	547	183	T	S	Act/Tct	-6.63	0	0	benign	0.1	neutral	0.42	neutral	1.95	neutral	0.35	neutral	-1.96	neutral_impact	-0.28	0.71	neutral	0.77	neutral	-0.44	0.31	neutral	0.49	0.55	0.39	neutral	0.06	neutral	0.17	neutral	0.21	neutral	6	0.52	neutral	0.66	deleterious	-6	neutral	0.15	neutral	0.17	medium_impact	0.13	medium_impact	-1.37	low_impact	0.63	0.8	26.87	28.4	0.49	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8132	8132	A	G	MI.6354	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	547	183	T	A	Act/Gct	-6.63	0	0	benign	0	neutral	0.51	neutral	1.89	neutral	-0.5	deleterious	-2.66	medium_impact	2.15	0.79	neutral	0.81	neutral	-0.13	1.52	neutral	0.62	0.65	0.59	disease	0.25	neutral	0.4	neutral	0.55	disease	1	0.49	neutral	0.76	deleterious	-3	neutral	0.19	neutral	2.08	high_impact	0.21	medium_impact	0.91	medium_impact	0.46	0.8	26.87	28.4	0.32	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8132	8132	A	C	MI.6355	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	547	183	T	P	Act/Cct	-6.63	0	0	possibly_damaging	0.62	neutral	0.2	neutral	1.85	neutral	-2.45	deleterious	-4.33	low_impact	1.54	0.59	damaging	0.32	neutral	3.26	22.80	deleterious	0.18	0.45	0.83	disease	0.77	disease	0.4	neutral	0.46	neutral	1	0.81	neutral	0.29	neutral	-3	neutral	0.51	deleterious	-0.92	medium_impact	-0.13	medium_impact	0.34	medium_impact	0.56	0.8	26.87	28.4	0.3	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8133	8133	C	T	MI.6356	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	548	183	T	I	aCt/aTt	2.37	0.28	0	benign	0.21	neutral	0.4	neutral	1.89	neutral	-1.68	deleterious	-4.25	low_impact	1.84	0.81	neutral	0.65	neutral	2.28	18.02	deleterious	0.44	0.55	0.78	disease	0.5	neutral	0.41	neutral	0.41	neutral	2	0.52	neutral	0.6	deleterious	-6	neutral	0.31	neutral	-0.18	medium_impact	0.11	medium_impact	0.62	medium_impact	0.68	0.85	26.87	28.4	0.29	N	0.73	polymorphism	1	0.04	rs386829026	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8133	8133	C	G	MI.6357	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	548	183	T	S	aCt/aGt	2.37	0.28	0	benign	0.1	neutral	0.42	neutral	1.95	neutral	0.35	neutral	-1.96	neutral_impact	-0.28	0.71	neutral	0.77	neutral	-0.22	1.00	neutral	0.49	0.55	0.39	neutral	0.06	neutral	0.17	neutral	0.21	neutral	6	0.52	neutral	0.66	deleterious	-6	neutral	0.15	neutral	0.17	medium_impact	0.13	medium_impact	-1.37	low_impact	0.63	0.8	26.87	28.4	0.46	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8133	8133	C	A	MI.6358	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	548	183	T	N	aCt/aAt	2.37	0.28	0	possibly_damaging	0.62	neutral	0.31	neutral	1.9	neutral	-0.99	deleterious	-3.52	neutral_impact	0.37	0.68	neutral	0.43	neutral	2.20	17.50	deleterious	0.55	0.6	0.66	disease	0.28	neutral	0.25	neutral	0.58	disease	1	0.72	neutral	0.35	neutral	-3	neutral	0.38	neutral	-0.92	medium_impact	0.01	medium_impact	-0.76	medium_impact	0.58	0.8	26.87	28.4	0.33	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8135	8135	T	A	MI.6359	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	550	184	F	I	Ttc/Atc	-12.16	0	0	probably_damaging	0.99	neutral	0.47	neutral	1.81	neutral	-1.7	deleterious	-4.35	low_impact	0.95	0.43	damaging	0.54	neutral	4.50	24.30	deleterious	0.23	0.45	0.55	disease	0.64	disease	0.41	neutral	0.2	neutral	6	0.99	deleterious	0.24	neutral	-2	neutral	0.77	deleterious	-2.58	low_impact	0.18	medium_impact	-0.22	medium_impact	0.65	0.8	29.07	68.25	0.49	N	0.34	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8826	8826	A	T	MI.636	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	300	100	M	I	atA/atT	3.83	0.49	0	probably_damaging	0.91	neutral	0.55	neutral	4.51	neutral	1.04	neutral	-2.05	low_impact	0.88	0.84	neutral	0.18	damaging	2.19	17.43	deleterious	0.53	0.65	0.37	neutral	0.61	disease	0.47	neutral	0.34	neutral	3	0.9	neutral	0.32	neutral	-2	neutral	0.63	deleterious	-1.71	low_impact	0.34	medium_impact	-0.34	medium_impact	0.78	0.9	27.43	8.87	0.27	N	0.91	disease_causing	0.99	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8135	8135	T	G	MI.6360	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	550	184	F	V	Ttc/Gtc	-12.16	0	0	probably_damaging	0.99	neutral	0.53	neutral	1.81	neutral	-1.41	deleterious	-5.29	low_impact	1.57	0.65	neutral	0.89	neutral	4.26	23.90	deleterious	0.28	0.45	0.49	neutral	0.83	disease	0.59	disease	0.56	disease	1	0.99	deleterious	0.27	neutral	-2	neutral	0.78	deleterious	-2.58	low_impact	0.23	medium_impact	0.37	medium_impact	0.59	0.8	29.07	68.25	0.31	N	0.01	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8135	8135	T	C	MI.6361	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	550	184	F	L	Ttc/Ctc	-12.16	0	0	probably_damaging	0.99	neutral	0.76	neutral	1.93	neutral	-1.34	deleterious	-4.08	neutral_impact	0.35	0.71	neutral	0.94	neutral	2.81	21.40	deleterious	0.48	0.55	0.28	neutral	0.5	neutral	0.37	neutral	0.2	neutral	6	0.99	deleterious	0.39	neutral	-2	neutral	0.70	deleterious	-2.58	low_impact	0.48	medium_impact	-0.78	medium_impact	0.84	0.9	29.07	68.25	0.31	N	0.02	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8136	8136	T	G	MI.6362	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	551	184	F	C	tTc/tGc	-0.4	0	0	probably_damaging	1	neutral	0.19	neutral	1.69	deleterious	-4.99	deleterious	-6.52	medium_impact	3.12	0.33	damaging	0.19	damaging	4.24	23.90	deleterious	0.2	0.45	0.87	disease	0.86	disease	0.69	disease	0.64	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	-0.14	medium_impact	1.82	medium_impact	0.36	0.8	29.07	68.25	0.52	P	0.57	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8136	8136	T	C	MI.6363	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	551	184	F	S	tTc/tCc	-0.4	0	0	probably_damaging	1	neutral	0.49	neutral	1.73	deleterious	-3.65	deleterious	-6.7	medium_impact	2.57	0.34	damaging	0.24	damaging	4.40	24.10	deleterious	0.14	0.4	0.74	disease	0.84	disease	0.68	disease	0.68	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.2	medium_impact	1.3	medium_impact	0.49	0.8	29.07	68.25	0.5	N	0.59	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8136	8136	T	A	MI.6364	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	551	184	F	Y	tTc/tAc	-0.4	0	0	probably_damaging	0.99	neutral	1	neutral	1.74	deleterious	-3.09	deleterious	-2.55	medium_impact	2.49	0.36	damaging	0.26	damaging	4.33	24.00	deleterious	0.3	0.45	0.71	disease	0.74	disease	0.68	disease	0.64	disease	3	0.99	deleterious	0.51	deleterious	1	deleterious	0.81	deleterious	-2.58	low_impact	1.86	high_impact	1.23	medium_impact	0.75	0.85	29.07	68.25	0.51	P	0.37	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8137	8137	C	A	MI.6365	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	552	184	F	L	ttC/ttA	7.44	0.96	0	probably_damaging	0.99	neutral	0.76	neutral	1.93	neutral	-1.34	deleterious	-4.08	neutral_impact	0.35	0.71	neutral	0.94	neutral	3.34	22.90	deleterious	0.48	0.55	0.28	neutral	0.5	neutral	0.37	neutral	0.2	neutral	6	0.99	deleterious	0.39	neutral	-2	neutral	0.70	deleterious	-2.58	low_impact	0.48	medium_impact	-0.78	medium_impact	0.84	0.9	29.07	68.25	0.46	N	0.02	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8137	8137	C	G	MI.6366	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	552	184	F	L	ttC/ttG	7.44	0.96	0	probably_damaging	0.99	neutral	0.76	neutral	1.93	neutral	-1.34	deleterious	-4.08	neutral_impact	0.35	0.71	neutral	0.94	neutral	3.06	22.40	deleterious	0.48	0.55	0.28	neutral	0.5	neutral	0.37	neutral	0.2	neutral	6	0.99	deleterious	0.39	neutral	-2	neutral	0.70	deleterious	-2.58	low_impact	0.48	medium_impact	-0.78	medium_impact	0.84	0.9	29.07	68.25	0.45	N	0.02	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8138	8138	A	G	MI.6367	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	553	185	T	A	Acc/Gcc	-7.09	0	0	probably_damaging	0.99	neutral	0.64	neutral	1.88	neutral	-2.02	neutral	-1.22	low_impact	1.41	0.77	neutral	0.86	neutral	2.52	19.57	deleterious	0.62	0.65	0.46	neutral	0.16	neutral	0.42	neutral	0.3	neutral	4	0.99	deleterious	0.33	neutral	-2	neutral	0.67	deleterious	-2.58	low_impact	0.34	medium_impact	0.22	medium_impact	0.48	0.8	30.84	46.13	0.27	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8138	8138	A	C	MI.6368	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	553	185	T	P	Acc/Ccc	-7.09	0	0	probably_damaging	1	neutral	0.25	neutral	1.84	deleterious	-3.71	deleterious	-2.87	medium_impact	2.65	0.59	damaging	0.38	neutral	3.61	23.20	deleterious	0.15	0.4	0.71	disease	0.58	disease	0.43	neutral	0.43	neutral	2	1	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	-0.06	medium_impact	1.38	medium_impact	0.56	0.8	30.84	46.13	0.32	N	0.86	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8138	8138	A	T	MI.6369	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	553	185	T	S	Acc/Tcc	-7.09	0	0	probably_damaging	0.99	neutral	0.55	neutral	1.87	neutral	-1.65	neutral	-1.56	neutral_impact	0.06	0.77	neutral	0.82	neutral	2.21	17.57	deleterious	0.47	0.55	0.35	neutral	0.14	neutral	0.25	neutral	0.28	neutral	4	0.99	deleterious	0.28	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.25	medium_impact	-1.05	low_impact	0.65	0.8	30.84	46.13	0.29	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8827	8827	A	C	MI.637	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	301	101	N	H	Aac/Cac	-0.8	0.02	0	probably_damaging	1	deleterious	0	neutral	4.31	neutral	-2.19	deleterious	-4.43	high_impact	3.84	0.57	damaging	0.34	neutral	3.03	22.30	deleterious	0.38	0.65	0.77	disease	0.73	disease	0.77	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.78	deleterious	-3.6	low_impact	-1.4	low_impact	2.19	high_impact	0.55	0.9	49.56	8.63	0.41	N	0.98	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8139	8139	C	T	MI.6370	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	554	185	T	I	aCc/aTc	1.91	0	0	probably_damaging	1	neutral	0.7	neutral	1.94	deleterious	-3.02	neutral	0.75	neutral_impact	0.08	0.76	neutral	0.8	neutral	1.40	12.79	neutral	0.47	0.55	0.57	disease	0.12	neutral	0.27	neutral	0.34	neutral	3	1	deleterious	0.35	neutral	-2	neutral	0.67	deleterious	-3.52	low_impact	0.41	medium_impact	-1.03	low_impact	0.68	0.85	30.84	46.13	0.31	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8139	8139	C	G	MI.6371	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	554	185	T	S	aCc/aGc	1.91	0	0	probably_damaging	0.99	neutral	0.55	neutral	1.87	neutral	-1.65	neutral	-1.56	neutral_impact	0.06	0.77	neutral	0.82	neutral	2.43	19.01	deleterious	0.47	0.55	0.35	neutral	0.14	neutral	0.25	neutral	0.28	neutral	4	0.99	deleterious	0.28	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.25	medium_impact	-1.05	low_impact	0.65	0.8	30.84	46.13	0.3	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8139	8139	C	A	MI.6372	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	554	185	T	N	aCc/aAc	1.91	0	0	probably_damaging	1	neutral	0.35	neutral	1.86	neutral	-1.99	deleterious	-2.61	low_impact	0.82	0.67	neutral	0.58	neutral	2.72	20.90	deleterious	0.5	0.6	0.52	disease	0.35	neutral	0.29	neutral	0.36	neutral	3	1	deleterious	0.18	neutral	-2	neutral	0.70	deleterious	-3.52	low_impact	0.06	medium_impact	-0.34	medium_impact	0.78	0.85	30.84	46.13	0.35	N	0.66	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8141	8141	G	C	MI.6373	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	556	186	A	P	Gct/Cct	-5.7	0	0	probably_damaging	1	neutral	0.21	neutral	1.79	neutral	-0.57	neutral	-2.27	low_impact	0.81	0.57	damaging	0.36	neutral	2.90	21.90	deleterious	0.13	0.4	0.3	neutral	0.65	disease	0.53	disease	0.24	neutral	5	1	deleterious	0.11	neutral	-2	neutral	0.75	deleterious	-3.52	low_impact	-0.11	medium_impact	-0.35	medium_impact	0.81	0.85	25.55	33	0.29	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8141	8141	G	T	MI.6374	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	556	186	A	S	Gct/Tct	-5.7	0	0	probably_damaging	1	neutral	0.44	neutral	1.75	neutral	-1.98	neutral	-0.27	neutral_impact	0.15	0.73	neutral	0.96	neutral	2.09	16.77	deleterious	0.34	0.5	0.41	neutral	0.2	neutral	0.22	neutral	0.37	neutral	3	1	deleterious	0.22	neutral	-2	neutral	0.69	deleterious	-3.52	low_impact	0.15	medium_impact	-0.97	medium_impact	0.77	0.85	25.55	33	0.41	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8141	8141	G	A	MI.6375	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	556	186	A	T	Gct/Act	-5.7	0	0	probably_damaging	1	neutral	0.41	neutral	1.76	neutral	-2.04	neutral	0.42	low_impact	0.95	0.75	neutral	0.79	neutral	1.90	15.59	deleterious	0.46	0.55	0.57	disease	0.18	neutral	0.23	neutral	0.37	neutral	3	1	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-3.52	low_impact	0.12	medium_impact	-0.22	medium_impact	0.62	0.8	25.55	33	0.43	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	COSM1169174	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8142	8142	C	T	MI.6376	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	557	186	A	V	gCt/gTt	-0.86	0	0	probably_damaging	1	neutral	0.52	neutral	1.79	neutral	-0.6	neutral	-0.28	neutral_impact	0.5	0.81	neutral	0.69	neutral	2.36	18.57	deleterious	0.3	0.45	0.39	neutral	0.27	neutral	0.28	neutral	0.45	neutral	1	1	deleterious	0.26	neutral	-2	neutral	0.67	deleterious	-3.52	low_impact	0.22	medium_impact	-0.64	medium_impact	0.70	0.85	25.55	33	0.3	N	0.80	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8142	8142	C	G	MI.6377	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	557	186	A	G	gCt/gGt	-0.86	0	0	probably_damaging	1	neutral	0.33	neutral	1.71	deleterious	-3.6	neutral	-2.46	medium_impact	2.27	0.65	neutral	0.67	neutral	4.13	23.80	deleterious	0.22	0.45	0.78	disease	0.3	neutral	0.52	disease	0.64	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.75	deleterious	-3.52	low_impact	0.04	medium_impact	1.02	medium_impact	0.80	0.85	25.55	33	0.35	N	0.42	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8142	8142	C	A	MI.6378	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	557	186	A	D	gCt/gAt	-0.86	0	0	probably_damaging	1	neutral	0.21	neutral	1.7	deleterious	-3.65	deleterious	-2.54	medium_impact	3.17	0.58	damaging	0.3	neutral	4.58	24.40	deleterious	0.11	0.4	0.86	disease	0.6	disease	0.68	disease	0.71	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	-0.11	medium_impact	1.87	medium_impact	0.70	0.85	25.55	33	0.3	N	0.70	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8144	8144	A	T	MI.6379	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	559	187	T	S	Aca/Tca	-20	0	0	possibly_damaging	0.5	neutral	0.87	neutral	1.97	neutral	-0.93	neutral	-0.38	neutral_impact	0.16	0.75	neutral	0.8	neutral	0.47	7.23	deleterious	0.63	0.7	0.45	neutral	0.11	neutral	0.43	neutral	0.3	neutral	4	0.41	neutral	0.69	deleterious	-3	neutral	0.39	neutral	-0.72	medium_impact	0.66	medium_impact	-0.96	medium_impact	0.68	0.85	59.47	14.31	0.29	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8827	8827	A	G	MI.638	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	301	101	N	D	Aac/Gac	-0.8	0.02	0	probably_damaging	0.99	deleterious	0	neutral	4.32	neutral	-1.63	deleterious	-4.42	high_impact	3.84	0.66	neutral	0.49	neutral	3.79	23.40	deleterious	0.51	0.65	0.45	neutral	0.69	disease	0.76	disease	0.7	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.73	deleterious	-2.65	low_impact	-1.4	low_impact	2.19	high_impact	0.65	0.9	49.56	8.63	0.45	N	0.97	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8144	8144	A	G	MI.6380	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	559	187	T	A	Aca/Gca	-20	0	0	benign	0.34	neutral	0.85	neutral	1.93	neutral	-1.35	neutral	-1.18	medium_impact	2.04	0.77	neutral	0.8	neutral	0.56	7.89	deleterious	0.58	0.65	0.5	disease	0.24	neutral	0.59	disease	0.42	neutral	2	0.22	neutral	0.76	deleterious	-3	neutral	0.33	neutral	-0.45	medium_impact	0.62	medium_impact	0.81	medium_impact	0.34	0.8	59.47	14.31	0.28	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8144	8144	A	C	MI.6381	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	559	187	T	P	Aca/Cca	-20	0	0	possibly_damaging	0.85	neutral	0.36	neutral	1.91	neutral	-2.39	neutral	-2.3	low_impact	1.29	0.7	neutral	0.72	neutral	2.45	19.11	deleterious	0.25	0.45	0.64	disease	0.7	disease	0.5	neutral	0.34	neutral	3	0.86	neutral	0.26	neutral	-3	neutral	0.78	deleterious	-1.42	low_impact	0.07	medium_impact	0.1	medium_impact	0.53	0.8	59.47	14.31	0.29	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8145	8145	C	T	MI.6382	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	560	187	T	M	aCa/aTa	-0.17	0	0	benign	0.16	neutral	0.16	neutral	1.88	deleterious	-3.68	neutral	-2.29	neutral_impact	0.72	0.95	neutral	0.78	neutral	1.03	10.84	neutral	0.34	0.5	0.77	disease	0.33	neutral	0.52	disease	0.65	disease	3	0.81	neutral	0.5	deleterious	-6	neutral	0.24	neutral	-0.05	medium_impact	-0.19	medium_impact	-0.43	medium_impact	0.48	0.8	59.47	14.31	0.41	N	0.27	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8145	8145	C	A	MI.6383	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	560	187	T	K	aCa/aAa	-0.17	0	0	possibly_damaging	0.54	neutral	0.95	neutral	1.94	neutral	-0.39	neutral	-2.41	neutral_impact	0.66	0.65	neutral	0.4	neutral	3.07	22.40	deleterious	0.38	0.5	0.34	neutral	0.47	neutral	0.54	disease	0.38	neutral	2	0.5	neutral	0.71	deleterious	-3	neutral	0.50	deleterious	-0.79	medium_impact	0.91	medium_impact	-0.49	medium_impact	0.72	0.85	59.47	14.31	0.24	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8147	8147	C	G	MI.6384	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	562	188	R	G	Cga/Gga	-8.7	0	0	probably_damaging	1	neutral	0.35	neutral	1.76	neutral	-2.78	deleterious	-5.41	medium_impact	3.17	0.35	damaging	0.24	damaging	4.40	24.10	deleterious	0.4	0.5	0.81	disease	0.82	disease	0.75	disease	0.67	disease	3	1	deleterious	0.18	neutral	1	deleterious	0.82	deleterious	-3.52	low_impact	0.06	medium_impact	1.87	medium_impact	0.30	0.8	68.72	19.82	0.53	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8147	8147	C	T	MI.6385	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	562	188	R	W	Cga/Tga	-8.7	0	0	probably_damaging	1	neutral	0.18	neutral	1.74	deleterious	-5.99	deleterious	-5.58	high_impact	4.07	0.45	damaging	0.11	damaging	5.36	25.90	deleterious	0.42	0.55	0.97	disease	0.88	disease	0.75	disease	0.63	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	-0.16	medium_impact	2.71	high_impact	0.68	0.85	68.72	19.82	0.33	N	1.00	polymorphism	0.99	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8148	8148	G	C	MI.6386	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	563	188	R	P	cGa/cCa	2.37	0.01	0	probably_damaging	1	neutral	0.22	neutral	1.76	deleterious	-3.38	deleterious	-5.36	medium_impact	3.17	0.34	damaging	0.16	damaging	4.37	24.10	deleterious	0.2	0.45	0.86	disease	0.9	disease	0.72	disease	0.63	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.89	deleterious	-3.52	low_impact	-0.1	medium_impact	1.87	medium_impact	0.28	0.8	68.72	19.82	0.54	P	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8148	8148	G	A	MI.6387	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	563	188	R	Q	cGa/cAa	2.37	0.01	0	probably_damaging	1	neutral	0.31	neutral	1.81	neutral	-0.71	deleterious	-2.68	medium_impact	2.35	0.45	damaging	0.2	damaging	4.67	24.50	deleterious	0.58	0.65	0.68	disease	0.84	disease	0.67	disease	0.55	disease	1	1	deleterious	0.16	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	0.01	medium_impact	1.1	medium_impact	0.86	0.9	68.72	19.82	0.38	N	1.00	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8148	8148	G	T	MI.6388	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	563	188	R	L	cGa/cTa	2.37	0.01	0	probably_damaging	1	neutral	0.66	neutral	1.81	neutral	-2.84	deleterious	-5.13	medium_impact	2.71	0.39	damaging	0.31	neutral	4.41	24.10	deleterious	0.4	0.5	0.81	disease	0.91	disease	0.72	disease	0.6	disease	2	1	deleterious	0.33	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	0.36	medium_impact	1.44	medium_impact	0.25	0.8	68.72	19.82	0.51	N	1.00	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8150	8150	C	T	MI.6389	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	565	189	P	S	Ccg/Tcg	-7.09	0	0	probably_damaging	1	neutral	0.75	neutral	1.74	neutral	-1.64	deleterious	-6.38	medium_impact	2.32	0.26	damaging	0.04	damaging	4.01	23.60	deleterious	0.5	0.6	0.33	neutral	0.62	disease	0.4	neutral	0.16	neutral	7	1	deleterious	0.38	neutral	1	deleterious	0.73	deleterious	-3.52	low_impact	0.47	medium_impact	1.07	medium_impact	0.25	0.8	68.28	19.3	0.48	N	0.94	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8827	8827	A	T	MI.639	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	301	101	N	Y	Aac/Tac	-0.8	0.02	0	probably_damaging	1	deleterious	0	neutral	4.32	neutral	-1.98	deleterious	-7.09	high_impact	3.84	0.59	damaging	0.36	neutral	3.63	23.20	deleterious	0.25	0.65	0.83	disease	0.8	disease	0.72	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	2.19	high_impact	0.51	0.9	49.56	8.63	0.32	N	1.00	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8150	8150	C	A	MI.6390	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	565	189	P	T	Ccg/Acg	-7.09	0	0	probably_damaging	1	neutral	0.61	neutral	1.76	neutral	-1.03	deleterious	-6.3	low_impact	1.89	0.19	damaging	0.03	damaging	3.76	23.30	deleterious	0.39	0.5	0.28	neutral	0.68	disease	0.39	neutral	0.16	neutral	7	1	deleterious	0.31	neutral	-2	neutral	0.71	deleterious	-3.52	low_impact	0.31	medium_impact	0.67	medium_impact	0.80	0.85	68.28	19.3	0.54	P	0.96	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8150	8150	C	G	MI.6391	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	565	189	P	A	Ccg/Gcg	-7.09	0	0	probably_damaging	1	neutral	0.76	neutral	1.78	neutral	-1.4	deleterious	-6.4	medium_impact	2.46	0.25	damaging	0.14	damaging	3.16	22.60	deleterious	0.42	0.55	0.47	neutral	0.53	disease	0.44	neutral	0.15	neutral	7	0.99	deleterious	0.38	neutral	1	deleterious	0.73	deleterious	-3.52	low_impact	0.48	medium_impact	1.2	medium_impact	0.79	0.85	68.28	19.3	0.64	P	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8151	8151	C	G	MI.6392	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	566	189	P	R	cCg/cGg	5.6	1	0	probably_damaging	1	neutral	0.63	neutral	1.71	neutral	-2.31	deleterious	-7.53	high_impact	3.56	0.14	damaging	0.02	damaging	3.68	23.30	deleterious	0.41	0.5	0.59	disease	0.79	disease	0.73	disease	0.7	disease	4	1	deleterious	0.32	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	0.33	medium_impact	2.23	high_impact	0.72	0.85	68.28	19.3	0.77	P	0.85	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8151	8151	C	T	MI.6393	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	566	189	P	L	cCg/cTg	5.6	1	0	probably_damaging	1	neutral	0.8	neutral	1.77	neutral	-2.48	deleterious	-8.29	medium_impact	2.02	0.21	damaging	0.03	damaging	4.42	24.20	deleterious	0.52	0.6	0.64	disease	0.77	disease	0.64	disease	0.65	disease	3	1	deleterious	0.4	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	0.54	medium_impact	0.79	medium_impact	0.73	0.85	68.28	19.3	0.71	P	0.92	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8151	8151	C	A	MI.6394	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	566	189	P	Q	cCg/cAg	5.6	1	0	probably_damaging	1	neutral	0.53	neutral	1.7	neutral	-1.8	deleterious	-6.58	high_impact	3.56	0.15	damaging	0.03	damaging	4.32	24.00	deleterious	0.32	0.5	0.56	disease	0.77	disease	0.69	disease	0.66	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.52	low_impact	0.23	medium_impact	2.23	high_impact	0.54	0.8	68.28	19.3	0.83	P	0.88	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8153	8153	G	T	MI.6395	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	568	190	G	W	Ggg/Tgg	-3.4	0	0	probably_damaging	1	neutral	0.18	neutral	-0.71	deleterious	-12.45	deleterious	-7.75	high_impact	4.63	0.17	damaging	0.01	damaging	4.61	24.40	deleterious	0.17	0.45	0.99	disease	0.86	disease	0.79	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.16	medium_impact	3.24	high_impact	0.34	0.8	68.72	19.86	0.62	P	0.98	disease_causing	0.98	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8153	8153	G	C	MI.6396	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	568	190	G	R	Ggg/Cgg	-3.4	0	0	probably_damaging	1	neutral	0.35	neutral	-0.69	deleterious	-8.78	deleterious	-7.73	high_impact	3.73	0.18	damaging	0.01	damaging	4.17	23.80	deleterious	0.18	0.45	0.93	disease	0.84	disease	0.83	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0.06	medium_impact	2.39	high_impact	0.72	0.85	68.72	19.86	0.68	P	1.00	disease_causing	0.97	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8154	8154	G	C	MI.6397	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	569	190	G	A	gGg/gCg	9.29	1	0	probably_damaging	1	neutral	0.51	neutral	-0.67	deleterious	-7.53	deleterious	-5.78	high_impact	3.94	0.2	damaging	0.09	damaging	3.32	22.90	deleterious	0.19	0.45	0.58	disease	0.67	disease	0.74	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.21	medium_impact	2.59	high_impact	0.44	0.8	68.72	19.86	0.85	P	0.85	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8154	8154	G	A	MI.6398	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	569	190	G	E	gGg/gAg	9.29	1	0	probably_damaging	1	neutral	0.27	neutral	-0.7	deleterious	-9.69	deleterious	-7.72	high_impact	4.08	0.16	damaging	0.01	damaging	4.07	23.70	deleterious	0.21	0.45	0.85	disease	0.84	disease	0.82	disease	0.67	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.03	medium_impact	2.72	high_impact	0.49	0.8	68.72	19.86	0.84	P	1.00	disease_causing	1	0.26	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8154	8154	G	T	MI.6399	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	569	190	G	V	gGg/gTg	9.29	1	0	probably_damaging	1	neutral	0.51	neutral	-0.7	deleterious	-9.39	deleterious	-8.71	high_impact	4.63	0.13	damaging	0.01	damaging	4.02	23.60	deleterious	0.16	0.45	0.93	disease	0.85	disease	0.76	disease	0.61	disease	2	1	deleterious	0.26	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.21	medium_impact	3.24	high_impact	0.46	0.8	68.72	19.86	0.74	P	1.00	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8554	8554	A	T	MI.64	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	28	10	I	F	Att/Ttt	-0.33	0	0	benign	0.02	neutral	0.09	neutral	4.68	neutral	-1.13	neutral	-1.33	low_impact	1.08	0.9	neutral	0.51	neutral	0.45	7.01	deleterious	0.39	0.65	0.67	disease	0.55	disease	0.36	neutral	0.51	disease	0	0.91	neutral	0.54	deleterious	-6	neutral	0.22	neutral	0.85	medium_impact	-0.28	medium_impact	-0.17	medium_impact	0.39	0.9	27.43	16.7	0.41	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8828	8828	A	G	MI.640	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	302	101	N	S	aAc/aGc	6.84	1	0	probably_damaging	0.99	neutral	0.28	neutral	4.36	neutral	-0.62	deleterious	-4.35	low_impact	1	0.64	neutral	0.61	neutral	2.91	21.90	deleterious	0.6	0.7	0.56	disease	0.52	disease	0.53	disease	0.39	neutral	2	0.99	deleterious	0.15	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	0.06	medium_impact	-0.24	medium_impact	0.54	0.9	49.56	8.63	0.51	P	0.91	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8156	8156	G	C	MI.6400	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	571	191	V	L	Gta/Cta	-11.7	0	0	benign	0.34	neutral	0.8	neutral	1.89	neutral	-1.38	neutral	-0.49	neutral_impact	0.39	0.75	neutral	0.97	neutral	-0.16	1.33	neutral	0.47	0.55	0.45	neutral	0.09	neutral	0.19	neutral	0.28	neutral	4	0.22	neutral	0.73	deleterious	-6	neutral	0.35	neutral	-0.45	medium_impact	0.54	medium_impact	-0.74	medium_impact	0.56	0.8	29.52	67.21	0.44	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8156	8156	G	T	MI.6401	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	571	191	V	L	Gta/Tta	-11.7	0	0	benign	0.34	neutral	0.8	neutral	1.89	neutral	-1.38	neutral	-0.49	neutral_impact	0.39	0.75	neutral	0.97	neutral	-0.04	2.25	deleterious	0.47	0.55	0.45	neutral	0.09	neutral	0.19	neutral	0.28	neutral	4	0.22	neutral	0.73	deleterious	-6	neutral	0.35	neutral	-0.45	medium_impact	0.54	medium_impact	-0.74	medium_impact	0.56	0.8	29.52	67.21	0.43	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8156	8156	G	A	MI.6402	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	571	191	V	M	Gta/Ata	-11.7	0	0	possibly_damaging	0.9	neutral	0.25	neutral	1.75	neutral	-2.28	neutral	-1.27	medium_impact	2.09	0.6	damaging	0.61	neutral	3.67	23.20	deleterious	0.38	0.5	0.53	disease	0.42	neutral	0.46	neutral	0.4	neutral	2	0.92	neutral	0.18	neutral	0	NA	0.65	deleterious	-1.61	low_impact	-0.06	medium_impact	0.85	medium_impact	0.79	0.85	29.52	67.21	0.41	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	COSM1319391	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8157	8157	T	A	MI.6403	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	572	191	V	E	gTa/gAa	-2.24	0	0	possibly_damaging	0.67	neutral	0.32	neutral	1.78	neutral	-1.13	deleterious	-4.94	medium_impact	2.74	0.5	damaging	0.42	neutral	4.61	24.50	deleterious	0.22	0.45	0.55	disease	0.79	disease	0.71	disease	0.72	disease	4	0.74	neutral	0.33	neutral	0	NA	0.65	deleterious	-1.01	low_impact	0.02	medium_impact	1.46	medium_impact	0.54	0.8	29.52	67.21	0.35	N	0.96	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8157	8157	T	G	MI.6404	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	572	191	V	G	gTa/gGa	-2.24	0	0	possibly_damaging	0.46	neutral	0.47	neutral	1.74	neutral	-2.55	deleterious	-5.91	high_impact	3.63	0.52	damaging	0.54	neutral	2.41	18.87	deleterious	0.24	0.45	0.81	disease	0.69	disease	0.61	disease	0.67	disease	3	0.5	neutral	0.51	deleterious	1	deleterious	0.57	deleterious	-0.66	medium_impact	0.18	medium_impact	2.3	high_impact	0.36	0.8	29.52	67.21	0.31	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8157	8157	T	C	MI.6405	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	572	191	V	A	gTa/gCa	-2.24	0	0	benign	0.01	neutral	0.56	neutral	1.79	neutral	-0.84	deleterious	-3.03	medium_impact	3.08	0.66	neutral	0.66	neutral	1.82	15.08	deleterious	0.37	0.5	0.62	disease	0.41	neutral	0.6	disease	0.65	disease	3	0.42	neutral	0.78	deleterious	-3	neutral	0.20	neutral	1.14	medium_impact	0.26	medium_impact	1.78	medium_impact	0.30	0.8	29.52	67.21	0.33	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8159	8159	T	G	MI.6406	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	574	192	Y	D	Tac/Gac	-5.01	0	0	probably_damaging	1	neutral	0.18	neutral	1.45	deleterious	-7.62	deleterious	-6.73	high_impact	3.58	0.59	damaging	0.33	neutral	4.06	23.70	deleterious	0.15	0.4	0.96	disease	0.78	disease	0.8	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.16	medium_impact	2.25	high_impact	0.27	0.8	68.72	15.57	0.34	N	0.91	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8159	8159	T	C	MI.6407	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	574	192	Y	H	Tac/Cac	-5.01	0	0	probably_damaging	1	neutral	0.5	neutral	1.56	deleterious	-5.84	deleterious	-4	medium_impact	2.89	0.65	neutral	0.37	neutral	3.70	23.30	deleterious	0.31	0.45	0.9	disease	0.52	disease	0.79	disease	0.71	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.86	deleterious	-3.52	low_impact	0.21	medium_impact	1.6	medium_impact	0.42	0.8	68.72	15.57	0.32	N	0.70	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8159	8159	T	A	MI.6408	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	574	192	Y	N	Tac/Aac	-5.01	0	0	probably_damaging	1	neutral	0.3	neutral	1.46	deleterious	-6.66	deleterious	-6.39	medium_impact	2.89	0.63	neutral	0.48	neutral	4.14	23.80	deleterious	0.21	0.45	0.93	disease	0.77	disease	0.72	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	0	medium_impact	1.6	medium_impact	0.29	0.8	68.72	15.57	0.28	N	0.88	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8160	8160	A	C	MI.6409	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	575	192	Y	S	tAc/tCc	5.83	0.97	0	probably_damaging	1	neutral	0.39	neutral	1.47	deleterious	-5.67	deleterious	-5.64	medium_impact	2.38	0.63	neutral	0.48	neutral	3.78	23.40	deleterious	0.18	0.45	0.55	disease	0.67	disease	0.68	disease	0.61	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.83	deleterious	-3.52	low_impact	0.1	medium_impact	1.13	medium_impact	0.33	0.8	68.72	15.57	0.49	N	0.86	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8828	8828	A	T	MI.641	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	302	101	N	I	aAc/aTc	6.84	1	0	probably_damaging	1	neutral	0.09	neutral	4.37	neutral	-0.32	deleterious	-8.01	medium_impact	2.48	0.63	neutral	0.58	neutral	3.77	23.40	deleterious	0.26	0.65	0.62	disease	0.87	disease	0.67	disease	0.71	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.28	medium_impact	1.03	medium_impact	0.51	0.9	49.56	8.63	0.49	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8160	8160	A	G	MI.6410	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	575	192	Y	C	tAc/tGc	5.83	0.97	0	probably_damaging	1	neutral	0.17	neutral	1.45	deleterious	-7.28	deleterious	-5.82	high_impact	3.58	0.66	neutral	0.36	neutral	3.55	23.10	deleterious	0.26	0.45	0.96	disease	0.83	disease	0.74	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	-0.18	medium_impact	2.25	high_impact	0.29	0.8	68.72	15.57	0.5	N	0.87	polymorphism	1	0.21	.	.	.	.	.	.	COSM218998	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8160	8160	A	T	MI.6411	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	575	192	Y	F	tAc/tTc	5.83	0.97	0	probably_damaging	1	neutral	0.81	neutral	2.01	neutral	-1.45	neutral	0.73	neutral_impact	-0.5	0.68	neutral	0.93	neutral	0.71	8.90	deleterious	0.27	0.45	0.25	neutral	0.07	neutral	0.25	neutral	0.21	neutral	6	1	deleterious	0.41	neutral	-2	neutral	0.68	deleterious	-3.52	low_impact	0.55	medium_impact	-1.57	low_impact	0.63	0.8	68.72	15.57	0.54	P	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8162	8162	T	A	MI.6412	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	577	193	Y	N	Tac/Aac	-3.63	0	0	probably_damaging	1	neutral	0.29	neutral	1.83	neutral	-2.64	deleterious	-8.39	high_impact	3.78	0.36	damaging	0.02	damaging	4.36	24.10	deleterious	0.33	0.5	0.45	neutral	0.87	disease	0.76	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	-0.01	medium_impact	2.44	high_impact	0.28	0.8	68.72	19.3	0.48	N	0.99	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8162	8162	T	G	MI.6413	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	577	193	Y	D	Tac/Gac	-3.63	0	0	probably_damaging	1	neutral	0.19	neutral	1.82	deleterious	-3.15	deleterious	-9.25	high_impact	3.78	0.29	damaging	0.03	damaging	4.11	23.80	deleterious	0.32	0.5	0.63	disease	0.88	disease	0.78	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	-0.14	medium_impact	2.44	high_impact	0.33	0.8	68.72	19.3	0.59	P	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8162	8162	T	C	MI.6414	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	577	193	Y	H	Tac/Cac	-3.63	0	0	probably_damaging	1	neutral	0.5	neutral	1.82	neutral	-2.96	deleterious	-4.73	medium_impact	3.15	0.38	damaging	0.02	damaging	3.77	23.40	deleterious	0.46	0.55	0.75	disease	0.76	disease	0.72	disease	0.67	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.21	medium_impact	1.85	medium_impact	0.35	0.8	68.72	19.3	0.42	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8163	8163	A	C	MI.6415	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	578	193	Y	S	tAc/tCc	7.44	1	0	probably_damaging	1	neutral	0.39	neutral	1.86	neutral	-1.7	deleterious	-8.28	medium_impact	3.15	0.33	damaging	0.04	damaging	3.86	23.50	deleterious	0.26	0.45	0.37	neutral	0.86	disease	0.74	disease	0.7	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	0.1	medium_impact	1.85	medium_impact	0.28	0.8	68.72	19.3	0.61	P	0.99	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8163	8163	A	G	MI.6416	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	578	193	Y	C	tAc/tGc	7.44	1	0	probably_damaging	1	neutral	0.17	neutral	1.82	deleterious	-3.4	deleterious	-8.28	medium_impact	3.23	0.28	damaging	0.02	damaging	3.71	23.30	deleterious	0.31	0.45	0.86	disease	0.9	disease	0.77	disease	0.69	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.88	deleterious	-3.52	low_impact	-0.18	medium_impact	1.92	medium_impact	0.19	0.8	68.72	19.3	0.79	P	0.96	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8163	8163	A	T	MI.6417	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	578	193	Y	F	tAc/tTc	7.44	1	0	probably_damaging	1	neutral	0.68	neutral	1.96	neutral	-0.31	deleterious	-3.15	low_impact	0.95	0.57	damaging	0.43	neutral	2.44	19.10	deleterious	0.41	0.5	0.47	neutral	0.28	neutral	0.47	neutral	0.39	neutral	2	1	deleterious	0.34	neutral	-2	neutral	0.75	deleterious	-3.52	low_impact	0.39	medium_impact	-0.22	medium_impact	0.42	0.8	68.72	19.3	0.54	P	0.87	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8165	8165	G	C	MI.6418	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	580	194	G	R	Ggt/Cgt	-5.24	0	0	probably_damaging	1	neutral	0.36	neutral	1.65	deleterious	-4.81	deleterious	-7.74	high_impact	4.63	0.19	damaging	0.01	damaging	4.14	23.80	deleterious	0.12	0.4	0.84	disease	0.86	disease	0.85	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0.07	medium_impact	3.24	high_impact	0.70	0.85	68.72	19.86	0.69	P	1.00	polymorphism	0.98	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8165	8165	G	A	MI.6419	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	580	194	G	S	Ggt/Agt	-5.24	0	0	probably_damaging	1	neutral	0.42	neutral	1.66	deleterious	-3.86	deleterious	-5.8	high_impact	4.63	0.16	damaging	0.01	damaging	4.41	24.10	deleterious	0.27	0.45	0.77	disease	0.86	disease	0.78	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.13	medium_impact	3.24	high_impact	0.73	0.85	68.72	19.86	0.76	P	0.98	polymorphism	0.99	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8828	8828	A	C	MI.642	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	302	101	N	T	aAc/aCc	6.84	1	0	probably_damaging	0.99	neutral	1	neutral	4.8	neutral	2.54	deleterious	-5.26	neutral_impact	0.73	0.62	neutral	0.52	neutral	3.26	22.80	deleterious	0.38	0.65	0.46	neutral	0.36	neutral	0.53	disease	0.42	neutral	2	0.99	deleterious	0.51	deleterious	-2	neutral	0.69	deleterious	-2.65	low_impact	1.98	high_impact	-0.47	medium_impact	0.58	0.9	49.56	8.63	0.44	N	0.96	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8165	8165	G	T	MI.6420	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	580	194	G	C	Ggt/Tgt	-5.24	0	0	probably_damaging	1	neutral	0.22	neutral	1.64	deleterious	-5.49	deleterious	-8.71	high_impact	4.63	0.19	damaging	0.01	damaging	4.31	24.00	deleterious	0.13	0.4	0.63	disease	0.91	disease	0.8	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.1	medium_impact	3.24	high_impact	0.71	0.85	68.72	19.86	0.62	P	0.99	polymorphism	0.96	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8166	8166	G	A	MI.6421	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	581	194	G	D	gGt/gAt	4.21	1	0	probably_damaging	1	neutral	0.21	neutral	1.63	deleterious	-5.61	deleterious	-6.77	high_impact	4.63	0.21	damaging	0.01	damaging	3.91	23.50	deleterious	0.13	0.4	0.89	disease	0.88	disease	0.84	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.11	medium_impact	3.24	high_impact	0.57	0.8	68.72	19.86	0.85	P	0.99	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8166	8166	G	C	MI.6422	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	581	194	G	A	gGt/gCt	4.21	1	0	probably_damaging	1	neutral	0.49	neutral	1.68	deleterious	-3.08	deleterious	-5.8	high_impact	4.28	0.22	damaging	0.07	damaging	3.30	22.90	deleterious	0.25	0.45	0.52	disease	0.74	disease	0.79	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	0.2	medium_impact	2.91	high_impact	0.80	0.85	68.72	19.86	0.85	P	0.85	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8166	8166	G	T	MI.6423	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	581	194	G	V	gGt/gTt	4.21	1	0	probably_damaging	1	neutral	0.52	neutral	1.72	neutral	-2.08	deleterious	-8.71	high_impact	4.63	0.15	damaging	0.01	damaging	3.95	23.60	deleterious	0.15	0.4	0.49	neutral	0.88	disease	0.81	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.22	medium_impact	3.24	high_impact	0.65	0.8	68.72	19.86	0.78	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8168	8168	C	G	MI.6424	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	583	195	Q	E	Caa/Gaa	-15.16	0	0	probably_damaging	0.98	neutral	0.27	neutral	1.81	neutral	-2.06	deleterious	-2.9	high_impact	3.85	0.17	damaging	0.04	damaging	3.26	22.80	deleterious	0.45	0.55	0.62	disease	0.76	disease	0.77	disease	0.69	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-2.3	low_impact	-0.03	medium_impact	2.5	high_impact	0.70	0.85	67.4	20.25	0.66	P	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8168	8168	C	A	MI.6425	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	583	195	Q	K	Caa/Aaa	-15.16	0	0	probably_damaging	0.99	neutral	0.29	neutral	1.83	neutral	-1.43	deleterious	-3.86	medium_impact	3.12	0.17	damaging	0.01	damaging	4.10	23.70	deleterious	0.45	0.55	0.46	neutral	0.86	disease	0.76	disease	0.7	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.85	deleterious	-2.58	low_impact	-0.01	medium_impact	1.82	medium_impact	0.58	0.8	67.4	20.25	0.68	P	0.97	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8169	8169	A	C	MI.6426	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	584	195	Q	P	cAa/cCa	4.44	1	0	probably_damaging	1	neutral	0.21	neutral	1.8	deleterious	-4.05	deleterious	-5.79	high_impact	3.99	0.16	damaging	0.04	damaging	3.52	23.10	deleterious	0.21	0.45	0.85	disease	0.86	disease	0.75	disease	0.62	disease	2	1	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	-0.11	medium_impact	2.64	high_impact	0.50	0.8	67.4	20.25	0.85	P	0.95	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8169	8169	A	T	MI.6427	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	584	195	Q	L	cAa/cTa	4.44	1	0	probably_damaging	0.99	neutral	0.65	neutral	1.94	neutral	-1.76	deleterious	-6.76	high_impact	3.99	0.14	damaging	0.03	damaging	4.00	23.60	deleterious	0.29	0.45	0.73	disease	0.87	disease	0.75	disease	0.68	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.88	deleterious	-2.58	low_impact	0.35	medium_impact	2.64	high_impact	0.23	0.8	67.4	20.25	0.83	P	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8169	8169	A	G	MI.6428	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	584	195	Q	R	cAa/cGa	4.44	1	0	probably_damaging	1	neutral	0.34	neutral	1.85	neutral	-1.53	deleterious	-3.86	high_impact	3.73	0.16	damaging	0.03	damaging	3.65	23.20	deleterious	0.49	0.55	0.44	neutral	0.82	disease	0.78	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.05	medium_impact	2.39	high_impact	0.58	0.8	67.4	20.25	0.87	P	0.95	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8170	8170	A	T	MI.6429	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	585	195	Q	H	caA/caT	8.59	1	0	probably_damaging	1	neutral	0.54	neutral	1.8	deleterious	-3.62	deleterious	-4.83	high_impact	4.2	0.13	damaging	0.03	damaging	3.74	23.30	deleterious	0.44	0.55	0.7	disease	0.77	disease	0.77	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.24	medium_impact	2.83	high_impact	0.68	0.85	67.4	20.25	0.87	P	0.86	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8829	8829	C	G	MI.643	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	303	101	N	K	aaC/aaG	8.69	1	0.06	probably_damaging	0.99	deleterious	0	neutral	4.35	neutral	-0.73	deleterious	-5.1	high_impact	3.84	0.57	damaging	0.4	neutral	3.97	23.60	deleterious	0.47	0.65	0.53	disease	0.79	disease	0.74	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.65	low_impact	-1.4	low_impact	2.19	high_impact	0.70	0.9	49.56	8.63	0.5	P	1.00	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8170	8170	A	C	MI.6430	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	585	195	Q	H	caA/caC	8.59	1	0	probably_damaging	1	neutral	0.54	neutral	1.8	deleterious	-3.62	deleterious	-4.83	high_impact	4.2	0.13	damaging	0.03	damaging	3.69	23.30	deleterious	0.44	0.55	0.7	disease	0.77	disease	0.77	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.24	medium_impact	2.83	high_impact	0.68	0.85	67.4	20.25	0.86	P	0.86	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8171	8171	T	A	MI.6431	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	586	196	C	S	Tgc/Agc	-0.17	0.33	0	probably_damaging	1	neutral	0.55	neutral	0.13	deleterious	-6.59	deleterious	-9.6	high_impact	3.92	0.11	damaging	0.02	damaging	3.87	23.50	deleterious	0.25	0.45	0.66	disease	0.9	disease	0.87	disease	0.74	disease	5	0.99	deleterious	0.28	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.25	medium_impact	2.57	high_impact	0.53	0.8	67.84	19.95	0.69	P	0.84	disease_causing	0.99	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8171	8171	T	G	MI.6432	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	586	196	C	G	Tgc/Ggc	-0.17	0.33	0	probably_damaging	1	neutral	0.46	neutral	0.12	deleterious	-6.91	deleterious	-11.52	high_impact	4.61	0.1	damaging	0.03	damaging	3.51	23.10	deleterious	0.2	0.45	0.87	disease	0.89	disease	0.88	disease	0.64	disease	3	1	deleterious	0.23	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.17	medium_impact	3.22	high_impact	0.44	0.8	67.84	19.95	0.67	P	0.96	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8171	8171	T	C	MI.6433	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	586	196	C	R	Tgc/Cgc	-0.17	0.33	0	probably_damaging	1	neutral	0.37	neutral	0.1	deleterious	-8.14	deleterious	-11.52	high_impact	4.26	0.13	damaging	0.02	damaging	3.73	23.30	deleterious	0.22	0.45	0.88	disease	0.91	disease	0.92	disease	0.64	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	0.08	medium_impact	2.89	high_impact	0.33	0.8	67.84	19.95	0.66	P	0.98	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8172	8172	G	A	MI.6434	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	587	196	C	Y	tGc/tAc	7.44	1	0	probably_damaging	1	neutral	1	neutral	0.1	deleterious	-8.61	deleterious	-10.56	high_impact	4.26	0.13	damaging	0.02	damaging	3.84	23.40	deleterious	0.23	0.45	0.89	disease	0.94	disease	0.9	disease	0.66	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.93	deleterious	-3.52	low_impact	1.86	high_impact	2.89	high_impact	0.50	0.8	67.84	19.95	0.67	P	0.97	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8172	8172	G	C	MI.6435	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	587	196	C	S	tGc/tCc	7.44	1	0	probably_damaging	1	neutral	0.55	neutral	0.13	deleterious	-6.59	deleterious	-9.6	high_impact	3.92	0.11	damaging	0.02	damaging	3.30	22.90	deleterious	0.25	0.45	0.66	disease	0.9	disease	0.87	disease	0.74	disease	5	0.99	deleterious	0.28	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.25	medium_impact	2.57	high_impact	0.53	0.8	67.84	19.95	0.74	P	0.84	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8172	8172	G	T	MI.6436	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	587	196	C	F	tGc/tTc	7.44	1	0	probably_damaging	1	neutral	0.72	neutral	0.1	deleterious	-8.21	deleterious	-10.56	high_impact	4.61	0.1	damaging	0.01	damaging	4.05	23.70	deleterious	0.19	0.45	0.87	disease	0.95	disease	0.9	disease	0.67	disease	3	1	deleterious	0.36	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	0.43	medium_impact	3.22	high_impact	0.46	0.8	67.84	19.95	0.72	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8173	8173	C	A	MI.6437	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	588	196	C	W	tgC/tgA	7.21	1	0	probably_damaging	1	neutral	0.17	neutral	0.09	deleterious	-10.04	deleterious	-10.56	high_impact	4.61	0.15	damaging	0.02	damaging	4.71	24.60	deleterious	0.16	0.45	0.96	disease	0.92	disease	0.92	disease	0.64	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	-0.18	medium_impact	3.22	high_impact	0.32	0.8	67.84	19.95	0.74	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8173	8173	C	G	MI.6438	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	588	196	C	W	tgC/tgG	7.21	1	0	probably_damaging	1	neutral	0.17	neutral	0.09	deleterious	-10.04	deleterious	-10.56	high_impact	4.61	0.15	damaging	0.02	damaging	4.48	24.20	deleterious	0.16	0.45	0.96	disease	0.92	disease	0.92	disease	0.64	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	-0.18	medium_impact	3.22	high_impact	0.32	0.8	67.84	19.95	0.74	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8174	8174	T	C	MI.6439	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	589	197	S	P	Tct/Cct	-0.17	0.71	0	probably_damaging	1	neutral	0.2	neutral	1.54	deleterious	-4.38	deleterious	-4.74	high_impact	3.73	0.17	damaging	0.04	damaging	4.13	23.80	deleterious	0.17	0.45	0.87	disease	0.82	disease	0.85	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	-0.13	medium_impact	2.39	high_impact	0.68	0.85	68.72	20.02	0.86	P	0.99	disease_causing	0.9	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8829	8829	C	A	MI.644	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	303	101	N	K	aaC/aaA	8.69	1	0.06	probably_damaging	0.99	deleterious	0	neutral	4.35	neutral	-0.73	deleterious	-5.1	high_impact	3.84	0.57	damaging	0.4	neutral	4.44	24.20	deleterious	0.47	0.65	0.53	disease	0.79	disease	0.74	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.65	low_impact	-1.4	low_impact	2.19	high_impact	0.70	0.9	49.56	8.63	0.51	P	1.00	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8174	8174	T	A	MI.6440	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	589	197	S	T	Tct/Act	-0.17	0.71	0	probably_damaging	0.99	neutral	0.38	neutral	1.57	deleterious	-3.19	deleterious	-2.83	medium_impact	2.73	0.16	damaging	0.03	damaging	4.02	23.60	deleterious	0.25	0.45	0.41	neutral	0.78	disease	0.76	disease	0.68	disease	4	0.99	deleterious	0.2	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	0.09	medium_impact	1.45	medium_impact	0.78	0.85	68.72	20.02	0.84	P	0.53	disease_causing	0.58	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8174	8174	T	G	MI.6441	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	589	197	S	A	Tct/Gct	-0.17	0.71	0	probably_damaging	0.99	neutral	0.5	neutral	1.6	neutral	-2.71	deleterious	-2.83	medium_impact	2.02	0.2	damaging	0.1	damaging	3.88	23.50	deleterious	0.37	0.5	0.29	neutral	0.66	disease	0.76	disease	0.66	disease	3	0.99	deleterious	0.26	neutral	1	deleterious	0.72	deleterious	-2.58	low_impact	0.21	medium_impact	0.79	medium_impact	0.59	0.8	68.72	20.02	0.85	P	0.36	polymorphism	0.71	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8175	8175	C	A	MI.6442	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	590	197	S	Y	tCt/tAt	5.83	1	0	probably_damaging	1	neutral	1	neutral	1.53	deleterious	-5.14	deleterious	-5.51	high_impact	3.73	0.17	damaging	0.06	damaging	4.18	23.80	deleterious	0.17	0.45	0.87	disease	0.89	disease	0.79	disease	0.65	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.52	low_impact	1.86	high_impact	2.39	high_impact	0.65	0.8	68.72	20.02	0.75	P	1.00	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8175	8175	C	G	MI.6443	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	590	197	S	C	tCt/tGt	5.83	1	0	probably_damaging	1	neutral	0.23	neutral	1.52	deleterious	-6.12	deleterious	-4.72	high_impact	4.42	0.2	damaging	0.02	damaging	3.76	23.30	deleterious	0.24	0.45	0.91	disease	0.82	disease	0.77	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.09	medium_impact	3.04	high_impact	0.61	0.8	68.72	20.02	0.81	P	0.91	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8175	8175	C	T	MI.6444	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	590	197	S	F	tCt/tTt	5.83	1	0	probably_damaging	1	neutral	0.71	neutral	1.52	deleterious	-5.44	deleterious	-5.58	high_impact	4.07	0.15	damaging	0.03	damaging	4.35	24.10	deleterious	0.16	0.45	0.85	disease	0.89	disease	0.79	disease	0.68	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.42	medium_impact	2.71	high_impact	0.39	0.8	68.72	20.02	0.78	P	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8177	8177	G	C	MI.6445	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	592	198	E	Q	Gaa/Caa	-2.01	0	0	probably_damaging	1	neutral	0.63	neutral	1.57	deleterious	-3.26	deleterious	-2.88	medium_impact	3.08	0.14	damaging	0.04	damaging	3.55	23.10	deleterious	0.34	0.5	0.73	disease	0.82	disease	0.74	disease	0.7	disease	4	1	deleterious	0.32	neutral	1	deleterious	0.87	deleterious	-3.52	low_impact	0.33	medium_impact	1.78	medium_impact	0.83	0.85	68.72	19.71	0.76	P	0.76	polymorphism	0.99	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8177	8177	G	A	MI.6446	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	592	198	E	K	Gaa/Aaa	-2.01	0	0	probably_damaging	1	neutral	0.89	neutral	1.55	deleterious	-3.32	deleterious	-3.84	high_impact	3.68	0.14	damaging	0.02	damaging	4.64	24.50	deleterious	0.32	0.5	0.8	disease	0.92	disease	0.79	disease	0.68	disease	4	1	deleterious	0.45	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0.71	medium_impact	2.35	high_impact	0.72	0.85	68.72	19.71	0.73	P	0.99	polymorphism	0.97	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8178	8178	A	G	MI.6447	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	593	198	E	G	gAa/gGa	7.21	1	0	probably_damaging	1	neutral	0.49	neutral	1.54	deleterious	-5.07	deleterious	-6.72	high_impact	4.58	0.1	damaging	0.06	damaging	4.48	24.20	deleterious	0.29	0.45	0.88	disease	0.83	disease	0.75	disease	0.62	disease	2	1	deleterious	0.25	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.2	medium_impact	3.19	high_impact	0.49	0.8	68.72	19.71	0.87	P	0.64	disease_causing	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8178	8178	A	C	MI.6448	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	593	198	E	A	gAa/gCa	7.21	1	0	probably_damaging	1	neutral	0.85	neutral	1.56	deleterious	-3.95	deleterious	-5.76	high_impact	4.58	0.19	damaging	0.11	damaging	3.91	23.50	deleterious	0.21	0.45	0.83	disease	0.83	disease	0.74	disease	0.68	disease	4	1	deleterious	0.43	neutral	2	deleterious	0.88	deleterious	-3.52	low_impact	0.62	medium_impact	3.19	high_impact	0.67	0.85	68.72	19.71	0.83	P	0.66	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8178	8178	A	T	MI.6449	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	593	198	E	V	gAa/gTa	7.21	1	0	probably_damaging	1	neutral	0.49	neutral	1.55	deleterious	-4.98	deleterious	-6.72	high_impact	4.23	0.12	damaging	0.03	damaging	4.47	24.20	deleterious	0.2	0.45	0.92	disease	0.93	disease	0.79	disease	0.65	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0.2	medium_impact	2.86	high_impact	0.68	0.85	68.72	19.71	0.85	P	0.82	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8830	8830	C	G	MI.645	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	304	102	L	V	Cta/Gta	-3.57	0	0	probably_damaging	0.99	neutral	0.06	neutral	4.17	neutral	-1.26	neutral	-2.01	medium_impact	2.23	0.86	neutral	0.48	neutral	3.35	22.90	deleterious	0.37	0.65	0.53	disease	0.5	neutral	0.56	disease	0.57	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.72	deleterious	-2.65	low_impact	-0.38	medium_impact	0.81	medium_impact	0.73	0.9	18.14	17.58	0.36	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8179	8179	A	T	MI.6450	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	594	198	E	D	gaA/gaT	8.59	1	0	probably_damaging	0.99	neutral	0.59	neutral	1.55	deleterious	-4.12	deleterious	-2.88	high_impact	4.58	0.19	damaging	0.03	damaging	4.05	23.70	deleterious	0.34	0.5	0.57	disease	0.8	disease	0.7	disease	0.67	disease	3	0.99	deleterious	0.3	neutral	2	deleterious	0.83	deleterious	-2.58	low_impact	0.29	medium_impact	3.19	high_impact	0.75	0.85	68.72	19.71	0.85	P	0.81	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8179	8179	A	C	MI.6451	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	594	198	E	D	gaA/gaC	8.59	1	0	probably_damaging	0.99	neutral	0.59	neutral	1.55	deleterious	-4.12	deleterious	-2.88	high_impact	4.58	0.19	damaging	0.03	damaging	3.90	23.50	deleterious	0.34	0.5	0.57	disease	0.8	disease	0.7	disease	0.67	disease	3	0.99	deleterious	0.3	neutral	2	deleterious	0.83	deleterious	-2.58	low_impact	0.29	medium_impact	3.19	high_impact	0.75	0.85	68.72	19.71	0.84	P	0.81	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8180	8180	A	C	MI.6452	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	595	199	I	L	Atc/Ctc	1.68	1	0	probably_damaging	0.98	neutral	0.81	neutral	2.16	neutral	1.76	neutral	-1.92	low_impact	1.09	0.13	damaging	0.05	damaging	3.87	23.50	deleterious	0.35	0.5	0.28	neutral	0.71	disease	0.59	disease	0.54	disease	1	0.98	deleterious	0.42	neutral	-2	neutral	0.69	deleterious	-2.3	low_impact	0.55	medium_impact	-0.08	medium_impact	0.70	0.85	68.72	19.93	0.85	P	0.71	disease_causing	0.69	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8180	8180	A	T	MI.6453	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	595	199	I	F	Atc/Ttc	1.68	1	0	probably_damaging	1	neutral	0.75	neutral	2	neutral	-1.03	deleterious	-3.84	medium_impact	2.25	0.13	damaging	0.03	damaging	3.84	23.40	deleterious	0.37	0.5	0.25	neutral	0.88	disease	0.73	disease	0.67	disease	3	1	deleterious	0.38	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	0.47	medium_impact	1	medium_impact	0.69	0.85	68.72	19.93	0.82	P	0.92	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8180	8180	A	G	MI.6454	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	595	199	I	V	Atc/Gtc	1.68	1	0	probably_damaging	0.95	neutral	0.64	neutral	1.85	neutral	-0.83	neutral	-0.96	medium_impact	2.96	0.14	damaging	0.07	damaging	3.11	22.50	deleterious	0.53	0.6	0.51	disease	0.61	disease	0.66	disease	0.64	disease	3	0.95	neutral	0.35	neutral	1	deleterious	0.70	deleterious	-1.91	low_impact	0.34	medium_impact	1.67	medium_impact	0.58	0.8	68.72	19.93	0.84	P	0.54	polymorphism	0.51	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8181	8181	T	A	MI.6455	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	596	199	I	N	aTc/aAc	5.6	1	0	probably_damaging	1	neutral	0.55	neutral	1.79	deleterious	-3.77	deleterious	-6.72	high_impact	4.11	0.15	damaging	0.02	damaging	4.84	24.80	deleterious	0.26	0.45	0.8	disease	0.89	disease	0.74	disease	0.67	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.25	medium_impact	2.75	high_impact	0.48	0.8	68.72	19.93	0.82	P	0.99	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8181	8181	T	C	MI.6456	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	596	199	I	T	aTc/aCc	5.6	1	0	probably_damaging	1	neutral	0.68	neutral	1.81	neutral	-2.14	deleterious	-4.8	high_impact	4.11	0.13	damaging	0.02	damaging	3.67	23.30	deleterious	0.37	0.5	0.61	disease	0.88	disease	0.72	disease	0.69	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.39	medium_impact	2.75	high_impact	0.52	0.8	68.72	19.93	0.81	P	0.96	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8181	8181	T	G	MI.6457	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	596	199	I	S	aTc/aGc	5.6	1	0	probably_damaging	1	neutral	0.87	neutral	1.8	neutral	-2.52	deleterious	-5.76	high_impact	4.11	0.12	damaging	0.06	damaging	4.50	24.30	deleterious	0.3	0.45	0.67	disease	0.9	disease	0.72	disease	0.69	disease	4	1	deleterious	0.44	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.66	medium_impact	2.75	high_impact	0.42	0.8	68.72	19.93	0.78	P	0.91	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8182	8182	C	A	MI.6458	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	597	199	I	M	atC/atA	7.44	1	0	probably_damaging	1	neutral	0.27	neutral	1.83	neutral	-1.37	deleterious	-2.88	medium_impact	3.02	0.15	damaging	0.03	damaging	3.92	23.50	deleterious	0.41	0.5	0.64	disease	0.74	disease	0.65	disease	0.65	disease	3	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	-0.03	medium_impact	1.73	medium_impact	0.79	0.85	68.72	19.93	0.88	P	0.79	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8182	8182	C	G	MI.6459	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	597	199	I	M	atC/atG	7.44	1	0	probably_damaging	1	neutral	0.27	neutral	1.83	neutral	-1.37	deleterious	-2.88	medium_impact	3.02	0.15	damaging	0.03	damaging	3.56	23.10	deleterious	0.41	0.5	0.64	disease	0.74	disease	0.65	disease	0.65	disease	3	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	-0.03	medium_impact	1.73	medium_impact	0.79	0.85	68.72	19.93	0.88	P	0.79	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8830	8830	C	A	MI.646	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	304	102	L	M	Cta/Ata	-3.57	0	0	probably_damaging	1	neutral	0.69	neutral	4.1	neutral	-1.86	neutral	-0.7	neutral_impact	0.32	0.84	neutral	0.71	neutral	1.87	15.38	deleterious	0.34	0.65	0.58	disease	0.05	neutral	0.32	neutral	0.31	neutral	4	1	deleterious	0.35	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.49	medium_impact	-0.82	medium_impact	0.70	0.9	18.14	17.58	0.3	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8183	8183	T	A	MI.6460	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	598	200	C	S	Tgt/Agt	-2.48	0	0	probably_damaging	1	neutral	0.86	neutral	0.13	deleterious	-6.59	deleterious	-9.59	high_impact	4.21	0.11	damaging	0.02	damaging	3.69	23.30	deleterious	0.23	0.45	0.62	disease	0.92	disease	0.82	disease	0.73	disease	5	0.99	deleterious	0.43	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.64	medium_impact	2.84	high_impact	0.42	0.8	68.72	19.58	0.59	P	0.84	disease_causing	0.99	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8183	8183	T	C	MI.6461	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	598	200	C	R	Tgt/Cgt	-2.48	0	0	probably_damaging	1	neutral	0.53	neutral	0.1	deleterious	-8.14	deleterious	-11.51	high_impact	3.86	0.13	damaging	0.02	damaging	3.61	23.20	deleterious	0.19	0.45	0.95	disease	0.94	disease	0.89	disease	0.65	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.95	deleterious	-3.52	low_impact	0.23	medium_impact	2.51	high_impact	0.24	0.8	68.72	19.58	0.6	P	0.98	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8183	8183	T	G	MI.6462	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	598	200	C	G	Tgt/Ggt	-2.48	0	0	probably_damaging	1	neutral	0.67	neutral	0.12	deleterious	-6.91	deleterious	-11.51	high_impact	4.21	0.11	damaging	0.03	damaging	3.48	23.10	deleterious	0.18	0.45	0.85	disease	0.92	disease	0.85	disease	0.66	disease	3	1	deleterious	0.34	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.38	medium_impact	2.84	high_impact	0.31	0.8	68.72	19.58	0.59	P	0.96	disease_causing	0.99	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8184	8184	G	C	MI.6463	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	599	200	C	S	tGt/tCt	7.44	1	0	probably_damaging	1	neutral	0.86	neutral	0.13	deleterious	-6.59	deleterious	-9.59	high_impact	4.21	0.11	damaging	0.02	damaging	3.45	23.00	deleterious	0.23	0.45	0.62	disease	0.92	disease	0.82	disease	0.73	disease	5	0.99	deleterious	0.43	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.64	medium_impact	2.84	high_impact	0.42	0.8	68.72	19.58	0.7	P	0.84	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8184	8184	G	A	MI.6464	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	599	200	C	Y	tGt/tAt	7.44	1	0	probably_damaging	1	neutral	0.12	neutral	0.1	deleterious	-8.61	deleterious	-10.55	high_impact	4.55	0.13	damaging	0.01	damaging	3.76	23.30	deleterious	0.21	0.45	0.98	disease	0.96	disease	0.88	disease	0.66	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.95	deleterious	-3.52	low_impact	-0.27	medium_impact	3.16	high_impact	0.44	0.8	68.72	19.58	0.78	P	0.97	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8184	8184	G	T	MI.6465	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	599	200	C	F	tGt/tTt	7.44	1	0	probably_damaging	1	neutral	0.21	neutral	0.1	deleterious	-8.21	deleterious	-10.55	high_impact	4.55	0.1	damaging	0.01	damaging	4.16	23.80	deleterious	0.18	0.45	0.97	disease	0.97	disease	0.86	disease	0.61	disease	2	1	deleterious	0.11	neutral	2	deleterious	0.95	deleterious	-3.52	low_impact	-0.11	medium_impact	3.16	high_impact	0.35	0.8	68.72	19.58	0.78	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8185	8185	T	G	MI.6466	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	600	200	C	W	tgT/tgG	7.21	1	0	probably_damaging	1	deleterious	0.03	neutral	0.09	deleterious	-10.04	deleterious	-10.55	high_impact	3.86	0.15	damaging	0.02	damaging	4.47	24.20	deleterious	0.16	0.45	0.99	disease	0.94	disease	0.89	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.94	deleterious	-3.52	low_impact	-0.63	medium_impact	2.51	high_impact	0.25	0.8	68.72	19.58	0.79	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8185	8185	T	A	MI.6467	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	600	200	C	W	tgT/tgA	7.21	1	0	probably_damaging	1	deleterious	0.03	neutral	0.09	deleterious	-10.04	deleterious	-10.55	high_impact	3.86	0.15	damaging	0.02	damaging	4.57	24.40	deleterious	0.16	0.45	0.99	disease	0.94	disease	0.89	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.94	deleterious	-3.52	low_impact	-0.63	medium_impact	2.51	high_impact	0.25	0.8	68.72	19.58	0.79	P	0.99	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8186	8186	G	T	MI.6468	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	601	201	G	W	Gga/Tga	-3.17	0	0	probably_damaging	1	neutral	0.18	neutral	-0.27	deleterious	-11.66	deleterious	-7.67	high_impact	4.58	0.19	damaging	0.02	damaging	4.70	24.60	deleterious	0.13	0.4	0.99	disease	0.91	disease	0.84	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	-0.16	medium_impact	3.19	high_impact	0.26	0.8	68.28	19.82	0.62	P	0.98	disease_causing	0.89	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8186	8186	G	C	MI.6469	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	601	201	G	R	Gga/Cga	-3.17	0	0	probably_damaging	1	neutral	0.4	neutral	-0.26	deleterious	-9.1	deleterious	-7.68	high_impact	4.58	0.18	damaging	0.01	damaging	4.17	23.80	deleterious	0.12	0.4	0.98	disease	0.9	disease	0.87	disease	0.74	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.94	deleterious	-3.52	low_impact	0.11	medium_impact	3.19	high_impact	0.58	0.8	68.28	19.82	0.67	P	1.00	disease_causing	0.84	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8831	8831	T	G	MI.647	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	305	102	L	R	cTa/cGa	-1.03	0	0	probably_damaging	1	deleterious	0.01	neutral	4	deleterious	-4.37	deleterious	-4.6	high_impact	3.81	0.73	neutral	0.09	damaging	4.14	23.80	deleterious	0.13	0.65	0.9	disease	0.88	disease	0.75	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-0.84	medium_impact	2.17	high_impact	0.68	0.9	18.14	17.58	0.29	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8187	8187	G	C	MI.6470	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	602	201	G	A	gGa/gCa	2.83	1	0	probably_damaging	1	neutral	0.65	neutral	-0.24	deleterious	-7.57	deleterious	-5.76	high_impact	4.24	0.22	damaging	0.09	damaging	3.28	22.80	deleterious	0.13	0.4	0.96	disease	0.78	disease	0.8	disease	0.72	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.35	medium_impact	2.87	high_impact	0.41	0.8	68.28	19.82	0.78	P	0.85	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8187	8187	G	T	MI.6471	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	602	201	G	V	gGa/gTa	2.83	1	0	probably_damaging	1	neutral	0.55	neutral	-0.27	deleterious	-10.17	deleterious	-8.64	high_impact	4.58	0.14	damaging	0.01	damaging	3.94	23.50	deleterious	0.12	0.4	0.99	disease	0.92	disease	0.83	disease	0.72	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0.25	medium_impact	3.19	high_impact	0.39	0.8	68.28	19.82	0.71	P	1.00	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8187	8187	G	A	MI.6472	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	602	201	G	E	gGa/gAa	2.83	1	0	probably_damaging	1	neutral	0.36	neutral	-0.26	deleterious	-8.84	deleterious	-7.67	high_impact	4.24	0.18	damaging	0.01	damaging	4.03	23.60	deleterious	0.13	0.4	0.98	disease	0.9	disease	0.87	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0.07	medium_impact	2.87	high_impact	0.43	0.8	68.28	19.82	0.8	P	1.00	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8189	8189	G	C	MI.6473	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	604	202	A	P	Gca/Cca	-16.08	0	0	possibly_damaging	0.82	neutral	0.39	neutral	1.8	neutral	-2.57	deleterious	-3.88	medium_impact	2.28	0.29	damaging	0.39	neutral	3.91	23.50	deleterious	0.2	0.45	0.29	neutral	0.9	disease	0.64	disease	0.71	disease	4	0.82	neutral	0.29	neutral	0	NA	0.75	deleterious	-1.33	low_impact	0.1	medium_impact	1.03	medium_impact	0.68	0.85	27.75	65.41	0.72	P	0.72	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8189	8189	G	A	MI.6474	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	604	202	A	T	Gca/Aca	-16.08	0	0	benign	0.04	neutral	0.52	neutral	1.88	neutral	-1.11	deleterious	-2.54	low_impact	1.35	0.37	damaging	0.54	neutral	2.43	19.04	deleterious	0.58	0.65	0.22	neutral	0.75	disease	0.38	neutral	0.21	neutral	6	0.44	neutral	0.74	deleterious	-6	neutral	0.23	neutral	0.57	medium_impact	0.22	medium_impact	0.16	medium_impact	0.79	0.85	27.75	65.41	0.57	P	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8189	8189	G	T	MI.6475	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	604	202	A	S	Gca/Tca	-16.08	0	0	possibly_damaging	0.45	neutral	0.69	neutral	1.84	neutral	-1.72	neutral	-1.2	low_impact	1	0.66	neutral	0.91	neutral	1.01	10.71	neutral	0.41	0.5	0.35	neutral	0.72	disease	0.39	neutral	0.21	neutral	6	0.36	neutral	0.62	deleterious	-3	neutral	0.44	deleterious	-0.64	medium_impact	0.4	medium_impact	-0.17	medium_impact	0.70	0.85	27.75	65.41	0.28	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8190	8190	C	A	MI.6476	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	605	202	A	E	gCa/gAa	1.91	0.98	0	possibly_damaging	0.76	neutral	0.63	neutral	1.81	neutral	-2.32	deleterious	-3.62	medium_impact	2.48	0.29	damaging	0.46	neutral	4.45	24.20	deleterious	0.29	0.45	0.22	neutral	0.9	disease	0.69	disease	0.72	disease	4	0.72	neutral	0.44	neutral	0	NA	0.61	deleterious	-1.19	low_impact	0.33	medium_impact	1.22	medium_impact	0.56	0.8	27.75	65.41	0.86	P	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8190	8190	C	G	MI.6477	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	605	202	A	G	gCa/gGa	1.91	0.98	0	possibly_damaging	0.45	neutral	0.5	neutral	1.79	neutral	-2.9	deleterious	-3	medium_impact	2.38	0.37	damaging	0.56	neutral	2.15	17.17	deleterious	0.37	0.5	0.6	disease	0.8	disease	0.6	disease	0.65	disease	3	0.47	neutral	0.53	deleterious	0	NA	0.49	deleterious	-0.64	medium_impact	0.21	medium_impact	1.13	medium_impact	0.68	0.85	27.75	65.41	0.7	P	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8190	8190	C	T	MI.6478	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	605	202	A	V	gCa/gTa	1.91	0.98	0	possibly_damaging	0.45	neutral	0.62	neutral	1.95	neutral	-0.33	deleterious	-3.36	neutral_impact	0.69	0.3	damaging	0.56	neutral	4.18	23.80	deleterious	0.46	0.55	0.41	neutral	0.84	disease	0.56	disease	0.36	neutral	3	0.39	neutral	0.59	deleterious	-3	neutral	0.49	deleterious	-0.64	medium_impact	0.32	medium_impact	-0.46	medium_impact	0.76	0.85	27.75	65.41	0.75	P	0.78	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8192	8192	A	G	MI.6479	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	607	203	N	D	Aac/Gac	-8.93	0	0	probably_damaging	0.99	neutral	0.21	neutral	1.92	neutral	0.63	deleterious	-4.8	medium_impact	2.02	0.31	damaging	0.26	damaging	4.02	23.60	deleterious	0.75	0.8	0.43	neutral	0.82	disease	0.74	disease	0.7	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-2.58	low_impact	-0.11	medium_impact	0.79	medium_impact	0.52	0.8	67.84	19.5	0.58	P	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8831	8831	T	A	MI.648	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	305	102	L	Q	cTa/cAa	-1.03	0	0	probably_damaging	1	deleterious	0.01	neutral	4	deleterious	-4.52	deleterious	-4.37	high_impact	3.81	0.78	neutral	0.12	damaging	4.05	23.70	deleterious	0.15	0.65	0.91	disease	0.76	disease	0.64	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-0.84	medium_impact	2.17	high_impact	0.78	0.9	18.14	17.58	0.29	N	0.95	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8192	8192	A	T	MI.6480	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	607	203	N	Y	Aac/Tac	-8.93	0	0	probably_damaging	1	neutral	1	neutral	1.91	neutral	-0.33	deleterious	-7.67	medium_impact	2.34	0.29	damaging	0.15	damaging	3.88	23.50	deleterious	0.44	0.55	0.36	neutral	0.92	disease	0.71	disease	0.73	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.83	deleterious	-3.52	low_impact	1.86	high_impact	1.09	medium_impact	0.36	0.8	67.84	19.5	0.55	P	0.98	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8192	8192	A	C	MI.6481	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	607	203	N	H	Aac/Cac	-8.93	0	0	probably_damaging	1	neutral	0.68	neutral	1.85	neutral	-1.89	deleterious	-4.8	high_impact	3.52	0.26	damaging	0.18	damaging	3.22	22.70	deleterious	0.57	0.65	0.28	neutral	0.85	disease	0.75	disease	0.71	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.79	deleterious	-3.52	low_impact	0.39	medium_impact	2.2	high_impact	0.36	0.8	67.84	19.5	0.68	P	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8193	8193	A	G	MI.6482	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	608	203	N	S	aAc/aGc	6.75	1	0	probably_damaging	0.97	neutral	0.57	neutral	1.92	neutral	0.5	deleterious	-4.8	medium_impact	2.27	0.25	damaging	0.31	neutral	3.12	22.60	deleterious	0.74	0.75	0.22	neutral	0.86	disease	0.71	disease	0.71	disease	4	0.97	neutral	0.3	neutral	1	deleterious	0.78	deleterious	-2.13	low_impact	0.27	medium_impact	1.02	medium_impact	0.28	0.8	67.84	19.5	0.9	P	0.87	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8193	8193	A	C	MI.6483	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	608	203	N	T	aAc/aCc	6.75	1	0	probably_damaging	0.99	neutral	0.39	neutral	1.88	neutral	-0.89	deleterious	-5.76	high_impact	4.07	0.25	damaging	0.26	damaging	3.46	23.00	deleterious	0.53	0.6	0.49	neutral	0.89	disease	0.73	disease	0.73	disease	5	0.99	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-2.58	low_impact	0.1	medium_impact	2.71	high_impact	0.46	0.8	67.84	19.5	0.93	P	0.92	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8193	8193	A	T	MI.6484	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	608	203	N	I	aAc/aTc	6.75	1	0	probably_damaging	1	neutral	0.48	neutral	1.86	neutral	-2.37	deleterious	-8.63	high_impact	4.07	0.27	damaging	0.36	neutral	3.97	23.60	deleterious	0.34	0.5	0.69	disease	0.93	disease	0.72	disease	0.76	disease	5	1	deleterious	0.24	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.19	medium_impact	2.71	high_impact	0.22	0.8	67.84	19.5	0.9	P	0.97	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8194	8194	C	G	MI.6485	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	609	203	N	K	aaC/aaG	6.75	1	0	probably_damaging	1	neutral	0.33	neutral	1.89	neutral	-0.03	deleterious	-5.76	medium_impact	3.17	0.27	damaging	0.17	damaging	4.20	23.90	deleterious	0.7	0.75	0.38	neutral	0.9	disease	0.75	disease	0.72	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	0.04	medium_impact	1.87	medium_impact	0.53	0.8	67.84	19.5	0.89	P	0.99	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8194	8194	C	A	MI.6486	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	609	203	N	K	aaC/aaA	6.75	1	0	probably_damaging	1	neutral	0.33	neutral	1.89	neutral	-0.03	deleterious	-5.76	medium_impact	3.17	0.27	damaging	0.17	damaging	4.64	24.50	deleterious	0.7	0.75	0.38	neutral	0.9	disease	0.75	disease	0.72	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.84	deleterious	-3.52	low_impact	0.04	medium_impact	1.87	medium_impact	0.53	0.8	67.84	19.5	0.89	P	0.99	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8195	8195	C	G	MI.6487	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	610	204	H	D	Cac/Gac	-2.94	0	0	probably_damaging	1	neutral	0.2	neutral	0.23	deleterious	-9.28	deleterious	-8.63	high_impact	4.57	0.2	damaging	0.02	damaging	4.02	23.60	deleterious	0.16	0.45	0.98	disease	0.86	disease	0.92	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	-0.13	medium_impact	3.18	high_impact	0.32	0.8	68.28	19.44	0.65	P	0.97	disease_causing	0.98	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8195	8195	C	T	MI.6488	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	610	204	H	Y	Cac/Tac	-2.94	0	0	probably_damaging	0.99	neutral	1	neutral	0.3	deleterious	-5.46	deleterious	-5.75	high_impact	4.22	0.18	damaging	0.01	damaging	3.86	23.50	deleterious	0.23	0.45	0.76	disease	0.88	disease	0.89	disease	0.75	disease	5	0.99	deleterious	0.51	deleterious	2	deleterious	0.89	deleterious	-2.58	low_impact	1.86	high_impact	2.85	high_impact	0.34	0.8	68.28	19.44	0.61	P	0.99	disease_causing	0.95	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8195	8195	C	A	MI.6489	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	610	204	H	N	Cac/Aac	-2.94	0	0	probably_damaging	1	neutral	0.34	neutral	0.24	deleterious	-7.84	deleterious	-6.71	high_impact	4.57	0.17	damaging	0.01	damaging	4.17	23.80	deleterious	0.22	0.45	0.96	disease	0.83	disease	0.89	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0.05	medium_impact	3.18	high_impact	0.31	0.8	68.28	19.44	0.71	P	0.96	disease_causing	0.94	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8831	8831	T	C	MI.649	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	305	102	L	P	cTa/cCa	-1.03	0	0	probably_damaging	1	deleterious	0	neutral	3.99	deleterious	-4.94	deleterious	-5.16	high_impact	3.81	0.8	neutral	0.12	damaging	3.79	23.40	deleterious	0.13	0.65	0.93	disease	0.86	disease	0.75	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.17	high_impact	0.68	0.9	18.14	17.58	0.29	N	0.97	disease_causing	0.99	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8196	8196	A	G	MI.6490	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	611	204	H	R	cAc/cGc	7.21	1	0	probably_damaging	1	neutral	0.35	neutral	0.23	deleterious	-8.72	deleterious	-7.67	high_impact	4.22	0.19	damaging	0.01	damaging	3.16	22.60	deleterious	0.24	0.45	0.97	disease	0.86	disease	0.91	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.93	deleterious	-3.52	low_impact	0.06	medium_impact	2.85	high_impact	0.33	0.8	68.28	19.44	0.78	P	0.95	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8196	8196	A	C	MI.6491	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	611	204	H	P	cAc/cCc	7.21	1	0	probably_damaging	1	neutral	0.2	neutral	0.23	deleterious	-9.68	deleterious	-9.59	high_impact	4.57	0.15	damaging	0.04	damaging	3.37	22.90	deleterious	0.17	0.45	0.98	disease	0.89	disease	0.88	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	-0.13	medium_impact	3.18	high_impact	0.26	0.8	68.28	19.44	0.78	P	0.98	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8196	8196	A	T	MI.6492	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	611	204	H	L	cAc/cTc	7.21	1	0	probably_damaging	1	neutral	0.66	neutral	0.23	deleterious	-8.06	deleterious	-10.55	high_impact	4.57	0.13	damaging	0.01	damaging	4.05	23.70	deleterious	0.15	0.45	0.91	disease	0.89	disease	0.89	disease	0.69	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.90	deleterious	-3.52	low_impact	0.36	medium_impact	3.18	high_impact	0.32	0.8	68.28	19.44	0.76	P	0.91	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8197	8197	C	G	MI.6493	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	612	204	H	Q	caC/caG	6.75	1	0	probably_damaging	1	neutral	0.3	neutral	0.23	deleterious	-8.52	deleterious	-7.67	high_impact	4.22	0.14	damaging	0.02	damaging	3.72	23.30	deleterious	0.24	0.45	0.97	disease	0.84	disease	0.9	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0	medium_impact	2.85	high_impact	0.42	0.8	68.28	19.44	0.8	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8197	8197	C	A	MI.6494	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	612	204	H	Q	caC/caA	6.75	1	0	probably_damaging	1	neutral	0.3	neutral	0.23	deleterious	-8.52	deleterious	-7.67	high_impact	4.22	0.14	damaging	0.02	damaging	4.08	23.70	deleterious	0.24	0.45	0.97	disease	0.84	disease	0.9	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-3.52	low_impact	0	medium_impact	2.85	high_impact	0.42	0.8	68.28	19.44	0.8	P	0.94	disease_causing	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8198	8198	A	G	MI.6495	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	613	205	S	G	Agt/Ggt	-2.94	0	0	probably_damaging	0.99	neutral	0.38	neutral	1.8	neutral	-0.88	deleterious	-3.84	low_impact	1.86	0.15	damaging	0.04	damaging	3.51	23.10	deleterious	0.38	0.5	0.51	disease	0.71	disease	0.75	disease	0.71	disease	4	0.99	deleterious	0.2	neutral	-2	neutral	0.76	deleterious	-2.58	low_impact	0.09	medium_impact	0.64	medium_impact	0.72	0.85	67.84	18.95	0.81	P	0.79	polymorphism	0.62	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8198	8198	A	C	MI.6496	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	613	205	S	R	Agt/Cgt	-2.94	0	0	probably_damaging	1	neutral	0.34	neutral	1.83	neutral	-2.16	deleterious	-4.8	high_impact	3.83	0.17	damaging	0.02	damaging	3.79	23.40	deleterious	0.23	0.45	0.65	disease	0.86	disease	0.81	disease	0.72	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.05	medium_impact	2.49	high_impact	0.64	0.8	67.84	18.95	0.79	P	1.00	disease_causing	0.76	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8198	8198	A	T	MI.6497	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	613	205	S	C	Agt/Tgt	-2.94	0	0	probably_damaging	1	neutral	0.18	neutral	1.76	deleterious	-4.84	deleterious	-4.79	high_impact	3.83	0.19	damaging	0.03	damaging	3.45	23.00	deleterious	0.25	0.45	0.92	disease	0.8	disease	0.74	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	-0.16	medium_impact	2.49	high_impact	0.70	0.85	67.84	18.95	0.78	P	0.91	disease_causing	0.72	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8199	8199	G	A	MI.6498	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	614	205	S	N	aGt/aAt	5.83	1	0	probably_damaging	0.97	neutral	0.35	neutral	1.82	neutral	-2.45	deleterious	-2.88	high_impact	3.83	0.16	damaging	0.03	damaging	3.67	23.20	deleterious	0.53	0.6	0.65	disease	0.74	disease	0.75	disease	0.71	disease	4	0.98	neutral	0.19	neutral	2	deleterious	0.79	deleterious	-2.13	low_impact	0.06	medium_impact	2.49	high_impact	0.50	0.8	67.84	18.95	0.86	P	0.80	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8199	8199	G	C	MI.6499	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	614	205	S	T	aGt/aCt	5.83	1	0	probably_damaging	0.97	neutral	0.39	neutral	1.83	neutral	-1.97	deleterious	-2.88	medium_impact	3.48	0.16	damaging	0.03	damaging	3.64	23.20	deleterious	0.32	0.5	0.4	neutral	0.75	disease	0.75	disease	0.7	disease	4	0.97	neutral	0.21	neutral	1	deleterious	0.78	deleterious	-2.13	low_impact	0.1	medium_impact	2.16	high_impact	0.79	0.85	67.84	18.95	0.85	P	0.53	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8555	8555	T	G	MI.65	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	29	10	I	S	aTt/aGt	-3.11	0	0	benign	0	neutral	0.23	neutral	4.74	neutral	0.07	neutral	-0.29	neutral_impact	0.68	0.85	neutral	0.83	neutral	2.52	19.60	deleterious	0.33	0.65	0.41	neutral	0.43	neutral	0.22	neutral	0.47	neutral	1	0.77	neutral	0.62	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	-0.01	medium_impact	-0.52	medium_impact	0.38	0.9	27.43	16.7	0.45	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8833	8833	G	C	MI.650	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	307	103	A	P	Gcc/Ccc	-0.33	0.56	0	probably_damaging	1	neutral	0.14	neutral	4.15	deleterious	-3.81	deleterious	-2.64	medium_impact	1.97	0.74	neutral	0.39	neutral	3.76	23.30	deleterious	0.1	0.65	0.89	disease	0.87	disease	0.72	disease	0.74	disease	5	1	deleterious	0.07	neutral	1	deleterious	0.88	deleterious	-3.6	low_impact	-0.15	medium_impact	0.59	medium_impact	0.79	0.9	22.12	23.58	0.26	N	0.86	disease_causing	0.73	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8199	8199	G	T	MI.6500	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	614	205	S	I	aGt/aTt	5.83	1	0	probably_damaging	1	neutral	0.41	neutral	1.79	neutral	-2.86	deleterious	-5.75	high_impact	3.62	0.19	damaging	0.03	damaging	4.28	24.00	deleterious	0.24	0.45	0.82	disease	0.91	disease	0.75	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.12	medium_impact	2.29	high_impact	0.73	0.85	67.84	18.95	0.86	P	0.99	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8201	8201	T	C	MI.6501	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	616	206	F	L	Ttc/Ctc	-0.4	0.15	0	probably_damaging	0.99	neutral	0.54	neutral	1.94	neutral	-0.92	deleterious	-5.73	medium_impact	2.48	0.24	damaging	0.03	damaging	4.28	24.00	deleterious	0.36	0.5	0.25	neutral	0.78	disease	0.7	disease	0.68	disease	4	0.99	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-2.58	low_impact	0.24	medium_impact	1.22	medium_impact	0.55	0.8	68.28	18.65	0.73	P	0.81	disease_causing	0.65	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8201	8201	T	G	MI.6502	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	616	206	F	V	Ttc/Gtc	-0.4	0.15	0	probably_damaging	1	neutral	0.44	neutral	1.88	neutral	-1.87	deleterious	-6.68	high_impact	3.75	0.24	damaging	0.02	damaging	4.33	24.00	deleterious	0.33	0.5	0.52	disease	0.88	disease	0.74	disease	0.73	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	0.15	medium_impact	2.41	high_impact	0.37	0.8	68.28	18.65	0.71	P	0.92	disease_causing	0.78	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8201	8201	T	A	MI.6503	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	616	206	F	I	Ttc/Atc	-0.4	0.15	0	probably_damaging	1	neutral	0.36	neutral	1.87	neutral	-2.62	deleterious	-5.73	high_impact	3.75	0.26	damaging	0.04	damaging	4.63	24.50	deleterious	0.26	0.45	0.32	neutral	0.85	disease	0.73	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.78	deleterious	-3.52	low_impact	0.07	medium_impact	2.41	high_impact	0.51	0.8	68.28	18.65	0.73	P	0.87	disease_causing	0.62	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8202	8202	T	C	MI.6504	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	617	206	F	S	tTc/tCc	5.83	1	0	probably_damaging	1	neutral	0.41	neutral	1.85	neutral	-0.58	deleterious	-7.64	medium_impact	3.06	0.25	damaging	0.02	damaging	4.43	24.20	deleterious	0.31	0.45	0.37	neutral	0.86	disease	0.71	disease	0.72	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.12	medium_impact	1.76	medium_impact	0.30	0.8	68.28	18.65	0.79	P	0.96	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8202	8202	T	G	MI.6505	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	617	206	F	C	tTc/tGc	5.83	1	0	probably_damaging	1	neutral	0.19	neutral	1.81	deleterious	-4.58	deleterious	-7.64	high_impact	4.3	0.25	damaging	0.02	damaging	4.26	23.90	deleterious	0.19	0.45	0.83	disease	0.84	disease	0.74	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.52	low_impact	-0.14	medium_impact	2.93	high_impact	0.23	0.8	68.28	18.65	0.78	P	1.00	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8202	8202	T	A	MI.6506	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	617	206	F	Y	tTc/tAc	5.83	1	0	probably_damaging	0.99	neutral	0.84	neutral	1.87	neutral	-1.27	deleterious	-2.8	low_impact	1.92	0.5	damaging	0.56	neutral	4.32	24.00	deleterious	0.32	0.5	0.62	disease	0.78	disease	0.67	disease	0.57	disease	1	0.99	deleterious	0.43	neutral	-2	neutral	0.80	deleterious	-2.58	low_impact	0.6	medium_impact	0.7	medium_impact	0.51	0.8	68.28	18.65	0.59	P	0.76	disease_causing	0.97	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8203	8203	C	G	MI.6507	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	618	206	F	L	ttC/ttG	3.06	0.99	0	probably_damaging	0.99	neutral	0.54	neutral	1.94	neutral	-0.92	deleterious	-5.73	medium_impact	2.48	0.24	damaging	0.03	damaging	4.53	24.30	deleterious	0.36	0.5	0.25	neutral	0.78	disease	0.7	disease	0.68	disease	4	0.99	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-2.58	low_impact	0.24	medium_impact	1.22	medium_impact	0.55	0.8	68.28	18.65	0.8	P	0.81	disease_causing	0.97	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8203	8203	C	A	MI.6508	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	618	206	F	L	ttC/ttA	3.06	0.99	0	probably_damaging	0.99	neutral	0.54	neutral	1.94	neutral	-0.92	deleterious	-5.73	medium_impact	2.48	0.24	damaging	0.03	damaging	4.87	24.90	deleterious	0.36	0.5	0.25	neutral	0.78	disease	0.7	disease	0.68	disease	4	0.99	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-2.58	low_impact	0.24	medium_impact	1.22	medium_impact	0.55	0.8	68.28	18.65	0.8	P	0.81	disease_causing	0.97	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8204	8204	A	G	MI.6509	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	619	207	M	V	Atg/Gtg	-4.09	0	0	probably_damaging	0.97	neutral	0.52	neutral	1.02	deleterious	-5.6	deleterious	-3.84	high_impact	4.56	0.12	damaging	0.03	damaging	2.98	22.20	deleterious	0.31	0.45	0.74	disease	0.86	disease	0.81	disease	0.71	disease	4	0.96	neutral	0.28	neutral	2	deleterious	0.86	deleterious	-2.13	low_impact	0.22	medium_impact	3.17	high_impact	0.37	0.8	68.72	19.3	0.67	P	0.89	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8833	8833	G	A	MI.651	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	307	103	A	T	Gcc/Acc	-0.33	0.56	0	probably_damaging	1	neutral	0.54	neutral	4.29	neutral	-0.74	neutral	-2.15	low_impact	1.18	0.89	neutral	0.63	neutral	4.18	23.80	deleterious	0.42	0.65	0.52	disease	0.45	neutral	0.39	neutral	0.39	neutral	2	1	deleterious	0.27	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.33	medium_impact	-0.09	medium_impact	0.73	0.9	22.12	23.58	0.28	N	0.52	polymorphism	0.57	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8204	8204	A	T	MI.6510	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	619	207	M	L	Atg/Ttg	-4.09	0	0	probably_damaging	0.95	neutral	0.65	neutral	1.12	deleterious	-4.78	deleterious	-2.88	high_impact	4.21	0.13	damaging	0.03	damaging	3.58	23.20	deleterious	0.24	0.45	0.63	disease	0.82	disease	0.79	disease	0.72	disease	4	0.94	neutral	0.35	neutral	2	deleterious	0.82	deleterious	-1.91	low_impact	0.35	medium_impact	2.84	high_impact	0.34	0.8	68.72	19.3	0.7	P	0.70	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8204	8204	A	C	MI.6511	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	619	207	M	L	Atg/Ctg	-4.09	0	0	probably_damaging	0.95	neutral	0.65	neutral	1.12	deleterious	-4.78	deleterious	-2.88	high_impact	4.21	0.13	damaging	0.03	damaging	3.60	23.20	deleterious	0.24	0.45	0.63	disease	0.82	disease	0.79	disease	0.72	disease	4	0.94	neutral	0.35	neutral	2	deleterious	0.82	deleterious	-1.91	low_impact	0.35	medium_impact	2.84	high_impact	0.34	0.8	68.72	19.3	0.69	P	0.70	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8205	8205	T	C	MI.6512	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	620	207	M	T	aTg/aCg	8.59	1	0	probably_damaging	1	neutral	0.38	neutral	0.96	deleterious	-6.15	deleterious	-5.75	high_impact	3.87	0.14	damaging	0.04	damaging	3.18	22.70	deleterious	0.26	0.45	0.76	disease	0.89	disease	0.79	disease	0.72	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.91	deleterious	-3.52	low_impact	0.09	medium_impact	2.52	high_impact	0.20	0.8	68.72	19.3	0.74	P	0.92	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8205	8205	T	A	MI.6513	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	620	207	M	K	aTg/aAg	8.59	1	0	probably_damaging	1	neutral	0.3	neutral	0.96	deleterious	-6.15	deleterious	-5.75	high_impact	4.56	0.15	damaging	0.02	damaging	4.29	24.00	deleterious	0.14	0.4	0.89	disease	0.92	disease	0.85	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.92	deleterious	-3.52	low_impact	0	medium_impact	3.17	high_impact	0.28	0.8	68.72	19.3	0.86	P	1.00	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8206	8206	G	C	MI.6514	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	621	207	M	I	atG/atC	4.67	1	0.05	probably_damaging	0.98	neutral	0.43	neutral	1.02	deleterious	-5.57	deleterious	-3.84	high_impact	3.87	0.18	damaging	0.04	damaging	3.76	23.30	deleterious	0.29	0.45	0.75	disease	0.86	disease	0.81	disease	0.7	disease	4	0.98	neutral	0.23	neutral	2	deleterious	0.88	deleterious	-2.3	low_impact	0.14	medium_impact	2.52	high_impact	0.42	0.8	68.72	19.3	0.83	P	0.78	disease_causing	1	0.26	rs28358883	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8206	8206	G	T	MI.6515	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	621	207	M	I	atG/atT	4.67	1	0.05	probably_damaging	0.98	neutral	0.43	neutral	1.02	deleterious	-5.57	deleterious	-3.84	high_impact	3.87	0.18	damaging	0.04	damaging	3.87	23.50	deleterious	0.29	0.45	0.75	disease	0.86	disease	0.81	disease	0.7	disease	4	0.98	neutral	0.23	neutral	2	deleterious	0.88	deleterious	-2.3	low_impact	0.14	medium_impact	2.52	high_impact	0.42	0.8	68.72	19.3	0.83	P	0.78	disease_causing	1	0.26	rs28358883	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8207	8207	C	G	MI.6516	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	622	208	P	A	Ccc/Gcc	-2.24	0	0	probably_damaging	1	neutral	0.51	neutral	1.86	neutral	-1.69	deleterious	-7.67	medium_impact	2.67	0.14	damaging	0.09	damaging	3.27	22.80	deleterious	0.37	0.5	0.35	neutral	0.72	disease	0.61	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	0.21	medium_impact	1.4	medium_impact	0.61	0.8	67.84	19.2	0.68	P	0.90	polymorphism	0.6	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8207	8207	C	T	MI.6517	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	622	208	P	S	Ccc/Tcc	-2.24	0	0	probably_damaging	1	neutral	0.43	neutral	1.84	neutral	-1.76	deleterious	-7.67	high_impact	3.56	0.09	damaging	0.02	damaging	4.07	23.70	deleterious	0.46	0.55	0.46	neutral	0.85	disease	0.6	disease	0.69	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.83	deleterious	-3.52	low_impact	0.14	medium_impact	2.23	high_impact	0.22	0.8	67.84	19.2	0.7	P	0.94	disease_causing	0.52	0.07	.	.	.	.	.	.	COSM5655026	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8207	8207	C	A	MI.6518	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	622	208	P	T	Ccc/Acc	-2.24	0	0	probably_damaging	1	neutral	0.4	neutral	1.85	neutral	-1.99	deleterious	-7.67	high_impact	4.12	0.11	damaging	0.02	damaging	3.86	23.50	deleterious	0.35	0.5	0.53	disease	0.85	disease	0.62	disease	0.7	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.11	medium_impact	2.76	high_impact	0.58	0.8	67.84	19.2	0.66	P	0.96	disease_causing	0.51	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8208	8208	C	A	MI.6519	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	623	208	P	H	cCc/cAc	4.44	0.99	0	probably_damaging	1	neutral	0.55	neutral	1.82	deleterious	-3.2	deleterious	-8.63	high_impact	4.46	0.1	damaging	0.02	damaging	4.14	23.80	deleterious	0.31	0.45	0.69	disease	0.88	disease	0.66	disease	0.71	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	0.25	medium_impact	3.08	high_impact	0.43	0.8	67.84	19.2	0.74	P	0.79	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8833	8833	G	T	MI.652	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	307	103	A	S	Gcc/Tcc	-0.33	0.56	0	probably_damaging	0.99	neutral	1	neutral	4.38	neutral	-0.06	neutral	-0.6	neutral_impact	0.16	0.9	neutral	0.8	neutral	2.54	19.75	deleterious	0.44	0.65	0.51	disease	0.38	neutral	0.34	neutral	0.35	neutral	3	0.99	deleterious	0.51	deleterious	-2	neutral	0.72	deleterious	-2.65	low_impact	1.98	high_impact	-0.96	medium_impact	0.85	0.9	22.12	23.58	0.25	N	0.04	polymorphism	0.75	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8208	8208	C	G	MI.6520	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	623	208	P	R	cCc/cGc	4.44	0.99	0	probably_damaging	1	neutral	0.34	neutral	1.89	neutral	-1.01	deleterious	-8.63	medium_impact	3.11	0.12	damaging	0.02	damaging	3.74	23.30	deleterious	0.29	0.45	0.44	neutral	0.91	disease	0.67	disease	0.72	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.05	medium_impact	1.81	medium_impact	0.51	0.8	67.84	19.2	0.79	P	0.85	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8208	8208	C	T	MI.6521	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	623	208	P	L	cCc/cTc	4.44	0.99	0	probably_damaging	1	neutral	0.65	neutral	1.93	neutral	-1.82	deleterious	-9.59	high_impact	3.65	0.08	damaging	0.03	damaging	4.58	24.40	deleterious	0.39	0.5	0.35	neutral	0.89	disease	0.6	disease	0.69	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.81	deleterious	-3.52	low_impact	0.35	medium_impact	2.32	high_impact	0.71	0.85	67.84	19.2	0.75	P	0.92	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8210	8210	A	C	MI.6522	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	625	209	I	L	Atc/Ctc	-11.47	0	0	probably_damaging	0.97	neutral	0.52	neutral	1.77	neutral	-1.51	neutral	-1.92	medium_impact	2.82	0.32	damaging	0.35	neutral	4.01	23.60	deleterious	0.45	0.55	0.57	disease	0.7	disease	0.49	neutral	0.51	disease	0	0.96	neutral	0.28	neutral	1	deleterious	0.71	deleterious	-2.13	low_impact	0.22	medium_impact	1.54	medium_impact	0.74	0.85	68.28	18.44	0.6	P	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8210	8210	A	T	MI.6523	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	625	209	I	F	Atc/Ttc	-11.47	0	0	probably_damaging	1	neutral	0.63	neutral	1.68	neutral	-0.53	deleterious	-3.83	medium_impact	2.35	0.32	damaging	0.25	damaging	4.07	23.70	deleterious	0.47	0.55	0.24	neutral	0.83	disease	0.51	disease	0.67	disease	3	0.99	deleterious	0.32	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	0.33	medium_impact	1.1	medium_impact	0.77	0.85	68.28	18.44	0.51	N	0.92	polymorphism	0.95	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8210	8210	A	G	MI.6524	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	625	209	I	V	Atc/Gtc	-11.47	0	0	probably_damaging	0.92	neutral	0.63	neutral	1.81	neutral	-1.44	neutral	-0.93	medium_impact	2.7	0.46	damaging	0.4	neutral	3.20	22.70	deleterious	0.62	0.65	0.5	neutral	0.54	disease	0.39	neutral	0.48	neutral	0	0.9	neutral	0.36	neutral	1	deleterious	0.67	deleterious	-1.71	low_impact	0.33	medium_impact	1.43	medium_impact	0.39	0.8	68.28	18.44	0.36	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8211	8211	T	G	MI.6525	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	626	209	I	S	aTc/aGc	6.98	1	0	probably_damaging	1	neutral	0.44	neutral	1.71	neutral	-2.94	deleterious	-5.74	high_impact	4.41	0.32	damaging	0.34	neutral	4.49	24.30	deleterious	0.32	0.5	0.53	disease	0.87	disease	0.56	disease	0.68	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	0.15	medium_impact	3.03	high_impact	0.45	0.8	68.28	18.44	0.77	P	0.91	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8211	8211	T	C	MI.6526	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	626	209	I	T	aTc/aCc	6.98	1	0	probably_damaging	1	neutral	0.37	neutral	1.71	neutral	-2.55	deleterious	-4.76	medium_impact	3.37	0.3	damaging	0.28	neutral	3.62	23.20	deleterious	0.47	0.55	0.6	disease	0.81	disease	0.45	neutral	0.66	disease	3	1	deleterious	0.19	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.08	medium_impact	2.05	high_impact	0.56	0.8	68.28	18.44	0.72	P	0.96	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8211	8211	T	A	MI.6527	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	626	209	I	N	aTc/aAc	6.98	1	0	probably_damaging	1	neutral	0.27	neutral	1.67	deleterious	-4.22	deleterious	-6.7	high_impact	4.06	0.34	damaging	0.24	damaging	4.64	24.50	deleterious	0.3	0.45	0.87	disease	0.85	disease	0.56	disease	0.74	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.52	low_impact	-0.03	medium_impact	2.7	high_impact	0.47	0.8	68.28	18.44	0.7	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8212	8212	C	A	MI.6528	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	627	209	I	M	atC/atA	5.6	1	0	probably_damaging	1	neutral	0.32	neutral	1.7	neutral	-2.71	deleterious	-2.86	medium_impact	3.12	0.36	damaging	0.35	neutral	4.05	23.70	deleterious	0.42	0.55	0.76	disease	0.72	disease	0.54	disease	0.64	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.02	medium_impact	1.82	medium_impact	0.75	0.85	68.28	18.44	0.73	P	0.79	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8212	8212	C	G	MI.6529	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	627	209	I	M	atC/atG	5.6	1	0	probably_damaging	1	neutral	0.32	neutral	1.7	neutral	-2.71	deleterious	-2.86	medium_impact	3.12	0.36	damaging	0.35	neutral	3.54	23.10	deleterious	0.42	0.55	0.76	disease	0.72	disease	0.54	disease	0.64	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.80	deleterious	-3.52	low_impact	0.02	medium_impact	1.82	medium_impact	0.75	0.85	68.28	18.44	0.72	P	0.79	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8834	8834	C	G	MI.653	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	308	103	A	G	gCc/gGc	2.21	0.99	0	probably_damaging	0.99	neutral	0.86	neutral	4.26	neutral	-1.06	neutral	2.17	neutral_impact	-0.62	0.82	neutral	0.95	neutral	1.19	11.67	neutral	0.3	0.65	0.42	neutral	0.11	neutral	0.29	neutral	0.24	neutral	5	0.99	deleterious	0.44	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	0.74	medium_impact	-1.63	low_impact	0.85	0.9	22.12	23.58	0.34	N	0.01	polymorphism	0.62	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8213	8213	G	T	MI.6530	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	628	210	V	F	Gtc/Ttc	-2.24	0	0	probably_damaging	1	neutral	0.56	neutral	1.83	deleterious	-3.91	deleterious	-4.1	medium_impact	2.93	0.43	damaging	0.35	neutral	4.00	23.60	deleterious	0.17	0.45	0.83	disease	0.91	disease	0.58	disease	0.72	disease	4	1	deleterious	0.28	neutral	1	deleterious	0.85	deleterious	-3.52	low_impact	0.26	medium_impact	1.64	medium_impact	0.78	0.85	67.84	17.77	0.41	N	0.94	disease_causing	0.9	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8213	8213	G	C	MI.6531	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	628	210	V	L	Gtc/Ctc	-2.24	0	0	probably_damaging	0.97	neutral	0.46	neutral	1.91	neutral	-2.33	neutral	-2.43	medium_impact	2.73	0.47	damaging	0.42	neutral	3.70	23.30	deleterious	0.36	0.5	0.41	neutral	0.77	disease	0.54	disease	0.61	disease	2	0.97	neutral	0.25	neutral	1	deleterious	0.75	deleterious	-2.13	low_impact	0.17	medium_impact	1.45	medium_impact	0.57	0.8	67.84	17.77	0.39	N	0.23	polymorphism	0.54	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8213	8213	G	A	MI.6532	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	628	210	V	I	Gtc/Atc	-2.24	0	0	probably_damaging	0.97	neutral	0.43	neutral	1.85	neutral	-2.36	neutral	-0.91	medium_impact	2.86	0.46	damaging	0.48	neutral	3.78	23.40	deleterious	0.39	0.5	0.76	disease	0.66	disease	0.43	neutral	0.48	neutral	0	0.97	neutral	0.23	neutral	1	deleterious	0.75	deleterious	-2.13	low_impact	0.14	medium_impact	1.58	medium_impact	0.81	0.85	67.84	17.77	0.41	N	0.30	polymorphism	0.8	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8214	8214	T	G	MI.6533	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	629	210	V	G	gTc/gGc	4.44	1	0	probably_damaging	1	neutral	0.27	neutral	1.8	neutral	-2.61	deleterious	-5.41	medium_impact	2.79	0.48	damaging	0.46	neutral	4.03	23.60	deleterious	0.23	0.45	0.68	disease	0.82	disease	0.6	disease	0.67	disease	3	1	deleterious	0.14	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	-0.03	medium_impact	1.51	medium_impact	0.50	0.8	67.84	17.77	0.47	N	0.84	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8214	8214	T	A	MI.6534	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	629	210	V	D	gTc/gAc	4.44	1	0	probably_damaging	1	neutral	0.18	neutral	1.8	neutral	-1.81	deleterious	-5.46	medium_impact	2.47	0.42	damaging	0.34	neutral	4.68	24.60	deleterious	0.16	0.45	0.31	neutral	0.9	disease	0.7	disease	0.75	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.77	deleterious	-3.52	low_impact	-0.16	medium_impact	1.21	medium_impact	0.65	0.8	67.84	17.77	0.6	P	0.90	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8214	8214	T	C	MI.6535	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	629	210	V	A	gTc/gCc	4.44	1	0	probably_damaging	1	neutral	0.41	neutral	1.9	neutral	-0.77	deleterious	-2.64	low_impact	1.2	0.61	neutral	0.62	neutral	2.58	19.97	deleterious	0.38	0.5	0.33	neutral	0.58	disease	0.35	neutral	0.44	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.73	deleterious	-3.52	low_impact	0.12	medium_impact	0.02	medium_impact	0.53	0.8	67.84	17.77	0.47	N	0.59	disease_causing	0.99	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8216	8216	C	G	MI.6536	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	631	211	L	V	Cta/Gta	-7.78	0	0	benign	0.09	neutral	1	neutral	2.02	neutral	2.29	neutral	1.11	neutral_impact	-1.38	0.79	neutral	0.89	neutral	-1.06	0.01	neutral	0.37	0.5	0.43	neutral	0.15	neutral	0.17	neutral	0.3	neutral	4	0.09	neutral	0.96	deleterious	-6	neutral	0.16	neutral	0.22	medium_impact	1.86	high_impact	-2.4	low_impact	0.71	0.85	28.19	51.33	0.33	N	0.46	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8216	8216	C	A	MI.6537	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	631	211	L	M	Cta/Ata	-7.78	0	0	possibly_damaging	0.82	neutral	0.33	neutral	1.83	neutral	-2.74	neutral	-0.54	low_impact	0.82	0.72	neutral	0.54	neutral	2.56	19.87	deleterious	0.29	0.45	0.74	disease	0.27	neutral	0.15	neutral	0.58	disease	2	0.84	neutral	0.26	neutral	-3	neutral	0.62	deleterious	-1.33	low_impact	0.04	medium_impact	-0.34	medium_impact	0.82	0.85	28.19	51.33	0.47	N	0.55	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8217	8217	T	C	MI.6538	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	632	211	L	P	cTa/cCa	-0.17	0	0	possibly_damaging	0.77	neutral	0.4	neutral	1.7	deleterious	-5.3	deleterious	-3.91	medium_impact	2.66	0.57	damaging	0.36	neutral	3.89	23.50	deleterious	0.15	0.45	0.91	disease	0.84	disease	0.51	disease	0.77	disease	5	0.77	neutral	0.32	neutral	0	NA	0.79	deleterious	-1.21	low_impact	0.11	medium_impact	1.39	medium_impact	0.61	0.8	28.19	51.33	0.27	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8217	8217	T	G	MI.6539	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	632	211	L	R	cTa/cGa	-0.17	0	0	possibly_damaging	0.6	neutral	0.3	neutral	1.7	deleterious	-5.01	deleterious	-4.22	medium_impact	2.66	0.63	neutral	0.41	neutral	4.00	23.60	deleterious	0.14	0.4	0.9	disease	0.86	disease	0.64	disease	0.84	disease	7	0.71	neutral	0.35	neutral	0	NA	0.69	deleterious	-0.89	medium_impact	0	medium_impact	1.39	medium_impact	0.46	0.8	28.19	51.33	0.27	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8834	8834	C	A	MI.654	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	308	103	A	D	gCc/gAc	2.21	0.99	0	probably_damaging	1	neutral	0.1	neutral	4.16	deleterious	-3.41	neutral	-2.24	medium_impact	3.21	0.89	neutral	0.51	neutral	4.53	24.30	deleterious	0.14	0.65	0.85	disease	0.85	disease	0.71	disease	0.76	disease	5	1	deleterious	0.05	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.25	medium_impact	1.65	medium_impact	0.74	0.9	22.12	23.58	0.49	N	0.74	disease_causing	0.77	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8217	8217	T	A	MI.6540	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	632	211	L	Q	cTa/cAa	-0.17	0	0	possibly_damaging	0.6	neutral	0.31	neutral	1.7	deleterious	-5.14	deleterious	-3.66	medium_impact	2.66	0.68	neutral	0.48	neutral	4.00	23.60	deleterious	0.15	0.4	0.9	disease	0.63	disease	0.5	neutral	0.65	disease	3	0.71	neutral	0.36	neutral	0	NA	0.72	deleterious	-0.89	medium_impact	0.01	medium_impact	1.39	medium_impact	0.70	0.85	28.19	51.33	0.32	N	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8219	8219	G	A	MI.6541	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	634	212	E	K	Gaa/Aaa	-5.01	0	0	possibly_damaging	0.58	neutral	0.87	neutral	1.88	neutral	-0.2	deleterious	-3.82	medium_impact	2.22	0.24	damaging	0.22	damaging	4.27	23.90	deleterious	0.4	0.5	0.28	neutral	0.87	disease	0.68	disease	0.72	disease	4	0.5	neutral	0.65	deleterious	0	NA	0.63	deleterious	-0.85	medium_impact	0.66	medium_impact	0.98	medium_impact	0.67	0.85	68.72	17.48	0.79	P	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8219	8219	G	C	MI.6542	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	634	212	E	Q	Gaa/Caa	-5.01	0	0	possibly_damaging	0.63	neutral	0.56	neutral	1.83	neutral	-1.21	deleterious	-2.87	medium_impact	2.27	0.27	damaging	0.38	neutral	3.23	22.80	deleterious	0.42	0.5	0.55	disease	0.71	disease	0.55	disease	0.64	disease	3	0.58	neutral	0.47	neutral	0	NA	0.64	deleterious	-0.94	medium_impact	0.26	medium_impact	1.02	medium_impact	0.70	0.85	68.72	17.48	0.87	P	0.76	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8220	8220	A	G	MI.6543	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	635	212	E	G	gAa/gGa	5.13	1	0	possibly_damaging	0.66	neutral	0.39	neutral	1.77	neutral	-2.89	deleterious	-6.7	high_impact	3.81	0.24	damaging	0.43	neutral	4.12	23.80	deleterious	0.37	0.5	0.71	disease	0.73	disease	0.68	disease	0.67	disease	3	0.69	neutral	0.37	neutral	1	deleterious	0.69	deleterious	-0.99	medium_impact	0.1	medium_impact	2.47	high_impact	0.44	0.8	68.72	17.48	0.92	P	0.64	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8220	8220	A	C	MI.6544	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	635	212	E	A	gAa/gCa	5.13	1	0	possibly_damaging	0.74	neutral	0.72	neutral	1.83	neutral	-1.67	deleterious	-5.74	medium_impact	3.46	0.28	damaging	0.35	neutral	3.58	23.20	deleterious	0.3	0.45	0.55	disease	0.68	disease	0.64	disease	0.66	disease	3	0.68	neutral	0.49	deleterious	0	NA	0.62	deleterious	-1.14	low_impact	0.43	medium_impact	2.14	high_impact	0.61	0.8	68.72	17.48	0.91	P	0.66	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8220	8220	A	T	MI.6545	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	635	212	E	V	gAa/gTa	5.13	1	0	possibly_damaging	0.8	neutral	0.3	neutral	1.79	neutral	-2.87	deleterious	-6.7	medium_impact	2.68	0.26	damaging	0.29	neutral	4.21	23.90	deleterious	0.32	0.5	0.72	disease	0.87	disease	0.66	disease	0.72	disease	4	0.84	neutral	0.25	neutral	0	NA	0.79	deleterious	-1.28	low_impact	0	medium_impact	1.41	medium_impact	0.72	0.85	68.72	17.48	0.9	P	0.82	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8221	8221	A	T	MI.6546	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	636	212	E	D	gaA/gaT	8.59	1	0	benign	0.01	neutral	0.59	neutral	1.8	neutral	-1.88	deleterious	-2.87	medium_impact	2.61	0.35	damaging	0.33	neutral	2.02	16.35	deleterious	0.42	0.5	0.61	disease	0.69	disease	0.52	disease	0.58	disease	2	0.39	neutral	0.79	deleterious	-3	neutral	0.25	neutral	1.14	medium_impact	0.29	medium_impact	1.34	medium_impact	0.80	0.85	68.72	17.48	0.75	P	0.81	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8221	8221	A	C	MI.6547	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	636	212	E	D	gaA/gaC	8.59	1	0	benign	0.01	neutral	0.59	neutral	1.8	neutral	-1.88	deleterious	-2.87	medium_impact	2.61	0.35	damaging	0.33	neutral	1.90	15.62	deleterious	0.42	0.5	0.61	disease	0.69	disease	0.52	disease	0.58	disease	2	0.39	neutral	0.79	deleterious	-3	neutral	0.25	neutral	1.14	medium_impact	0.29	medium_impact	1.34	medium_impact	0.80	0.85	68.72	17.48	0.75	P	0.81	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8222	8222	T	G	MI.6548	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	637	213	L	V	Tta/Gta	0.06	0	0	probably_damaging	0.98	neutral	0.4	neutral	2.31	neutral	1.82	neutral	0.17	neutral_impact	-1.74	0.66	neutral	0.37	neutral	2.37	18.63	deleterious	0.42	0.55	0.4	neutral	0.41	neutral	0.15	neutral	0.47	neutral	1	0.99	deleterious	0.21	neutral	-2	neutral	0.68	deleterious	-2.3	low_impact	0.11	medium_impact	-2.74	low_impact	0.64	0.8	23.79	40.34	0.48	N	0.36	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8222	8222	T	A	MI.6549	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	637	213	L	M	Tta/Ata	0.06	0	0	probably_damaging	1	neutral	0.15	neutral	1.92	neutral	-1.44	neutral	0.28	neutral_impact	-0.92	0.8	neutral	0.94	neutral	2.78	21.30	deleterious	0.36	0.5	0.47	neutral	0.3	neutral	0.16	neutral	0.45	neutral	1	1	deleterious	0.08	neutral	-2	neutral	0.70	deleterious	-3.52	low_impact	-0.21	medium_impact	-1.97	low_impact	0.78	0.85	23.79	40.34	0.49	N	0.13	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8834	8834	C	T	MI.655	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	308	103	A	V	gCc/gTc	2.21	0.99	0	probably_damaging	1	neutral	0.37	neutral	4.26	neutral	-1.09	deleterious	-2.99	low_impact	1.64	0.87	neutral	0.67	neutral	4.38	24.10	deleterious	0.33	0.65	0.38	neutral	0.65	disease	0.59	disease	0.63	disease	3	1	deleterious	0.19	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.16	medium_impact	0.31	medium_impact	0.77	0.9	22.12	23.58	0.45	N	0.68	polymorphism	0.57	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8223	8223	T	G	MI.6550	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	638	213	L	W	tTa/tGa	-2.71	0	0	probably_damaging	1	deleterious	0.03	neutral	1.9	deleterious	-3.77	neutral	-1.89	low_impact	0.98	0.55	damaging	0.16	damaging	3.94	23.50	deleterious	0.16	0.45	0.83	disease	0.65	disease	0.37	neutral	0.54	disease	1	1	deleterious	0.02	neutral	2	deleterious	0.80	deleterious	-3.52	low_impact	-0.63	medium_impact	-0.19	medium_impact	0.63	0.8	23.79	40.34	0.3	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8223	8223	T	C	MI.6551	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	638	213	L	S	tTa/tCa	-2.71	0	0	probably_damaging	1	neutral	0.82	neutral	2.01	neutral	-0.41	neutral	2.11	neutral_impact	-2.21	0.72	neutral	0.72	neutral	1.62	13.95	neutral	0.31	0.45	0.23	neutral	0.05	neutral	0.1	neutral	0.24	neutral	5	1	deleterious	0.41	neutral	-2	neutral	0.65	deleterious	-3.52	low_impact	0.57	medium_impact	-3.18	low_impact	0.63	0.8	23.79	40.34	0.33	N	0.62	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8224	8224	A	T	MI.6552	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	639	213	L	F	ttA/ttT	2.83	0.03	0	probably_damaging	1	neutral	0.15	neutral	1.94	neutral	-1.5	neutral	-0.75	neutral_impact	-1.11	0.68	neutral	0.55	neutral	2.63	20.40	deleterious	0.43	0.55	0.55	disease	0.46	neutral	0.12	neutral	0.61	disease	2	1	deleterious	0.08	neutral	-2	neutral	0.74	deleterious	-3.52	low_impact	-0.21	medium_impact	-2.15	low_impact	0.64	0.8	23.79	40.34	0.51	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8224	8224	A	C	MI.6553	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	639	213	L	F	ttA/ttC	2.83	0.03	0	probably_damaging	1	neutral	0.15	neutral	1.94	neutral	-1.5	neutral	-0.75	neutral_impact	-1.11	0.68	neutral	0.55	neutral	2.52	19.59	deleterious	0.43	0.55	0.55	disease	0.46	neutral	0.12	neutral	0.61	disease	2	1	deleterious	0.08	neutral	-2	neutral	0.74	deleterious	-3.52	low_impact	-0.21	medium_impact	-2.15	low_impact	0.64	0.8	23.79	40.34	0.49	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8225	8225	A	C	MI.6554	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	640	214	I	L	Att/Ctt	-5.7	0	0	probably_damaging	0.97	neutral	0.72	neutral	2.04	neutral	0.4	neutral	-0.95	neutral_impact	0.74	0.66	neutral	0.68	neutral	2.76	21.20	deleterious	0.53	0.6	0.27	neutral	0.45	neutral	0.25	neutral	0.46	neutral	1	0.96	neutral	0.38	neutral	-2	neutral	0.64	deleterious	-2.13	low_impact	0.43	medium_impact	-0.41	medium_impact	0.49	0.8	32.6	72.72	0.3	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8225	8225	A	T	MI.6555	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	640	214	I	F	Att/Ttt	-5.7	0	0	probably_damaging	0.99	neutral	0.7	neutral	1.93	neutral	-2.01	deleterious	-2.76	medium_impact	2.79	0.55	damaging	0.48	neutral	3.89	23.50	deleterious	0.54	0.6	0.24	neutral	0.63	disease	0.62	disease	0.71	disease	4	0.99	deleterious	0.36	neutral	1	deleterious	0.71	deleterious	-2.58	low_impact	0.41	medium_impact	1.51	medium_impact	0.58	0.8	32.6	72.72	0.28	N	0.70	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8225	8225	A	G	MI.6556	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	640	214	I	V	Att/Gtt	-5.7	0	0	probably_damaging	0.97	neutral	0.71	neutral	2.16	neutral	2.28	neutral	0.42	neutral_impact	-1.12	0.75	neutral	0.98	neutral	0.50	7.40	deleterious	0.6	0.65	0.46	neutral	0.06	neutral	0.22	neutral	0.26	neutral	5	0.96	neutral	0.37	neutral	-2	neutral	0.61	deleterious	-2.13	low_impact	0.42	medium_impact	-2.16	low_impact	0.29	0.8	32.6	72.72	0.34	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8226	8226	T	C	MI.6557	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	641	214	I	T	aTt/aCt	1.91	0.94	0	probably_damaging	0.99	neutral	0.44	neutral	1.97	neutral	-1.34	neutral	-1.17	neutral_impact	0.65	0.79	neutral	0.91	neutral	2.30	18.17	deleterious	0.44	0.55	0.35	neutral	0.37	neutral	0.31	neutral	0.46	neutral	1	0.99	deleterious	0.23	neutral	-2	neutral	0.69	deleterious	-2.58	low_impact	0.15	medium_impact	-0.5	medium_impact	0.41	0.8	32.6	72.72	0.31	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8226	8226	T	A	MI.6558	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	641	214	I	N	aTt/aAt	1.91	0.94	0	probably_damaging	1	neutral	0.38	neutral	1.9	deleterious	-3.23	deleterious	-3.98	medium_impact	2.24	0.58	damaging	0.43	neutral	4.71	24.60	deleterious	0.37	0.5	0.66	disease	0.73	disease	0.62	disease	0.71	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.78	deleterious	-3.52	low_impact	0.09	medium_impact	1	medium_impact	0.51	0.8	32.6	72.72	0.33	N	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8226	8226	T	G	MI.6559	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	641	214	I	S	aTt/aGt	1.91	0.94	0	probably_damaging	0.99	neutral	0.48	neutral	1.93	neutral	-2.09	deleterious	-2.83	low_impact	1.9	0.66	neutral	0.71	neutral	4.46	24.20	deleterious	0.39	0.5	0.49	neutral	0.71	disease	0.6	disease	0.7	disease	4	0.99	deleterious	0.25	neutral	-2	neutral	0.74	deleterious	-2.58	low_impact	0.19	medium_impact	0.68	medium_impact	0.39	0.8	32.6	72.72	0.31	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8836	8836	A	G	MI.656	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	310	104	M	V	Atg/Gtg	-10.05	0	0.01	possibly_damaging	0.87	neutral	0.07	neutral	4.29	neutral	-1.23	neutral	-2.46	low_impact	1.73	0.9	neutral	0.51	neutral	2.69	20.80	deleterious	0.55	0.65	0.53	disease	0.63	disease	0.63	disease	0.71	disease	4	0.97	neutral	0.1	neutral	-3	neutral	0.65	deleterious	-1.54	low_impact	-0.34	medium_impact	0.39	medium_impact	0.58	0.9	48.23	8.5	0.49	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	A8836G	LHON	+	-	Reported	2	.	P	P	damaging
chrM	8227	8227	T	G	MI.6560	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	642	214	I	M	atT/atG	3.06	0.95	0.01	probably_damaging	1	neutral	0.24	neutral	1.94	neutral	-0.99	neutral	-1.27	low_impact	1.5	0.59	damaging	0.41	neutral	3.64	23.20	deleterious	0.64	0.7	0.3	neutral	0.43	neutral	0.59	disease	0.5	neutral	0	1	deleterious	0.12	neutral	-2	neutral	0.67	deleterious	-3.52	low_impact	-0.07	medium_impact	0.3	medium_impact	0.55	0.8	32.6	72.72	0.44	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8227	8227	T	A	MI.6561	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	642	214	I	M	atT/atA	3.06	0.95	0.01	probably_damaging	1	neutral	0.24	neutral	1.94	neutral	-0.99	neutral	-1.27	low_impact	1.5	0.59	damaging	0.41	neutral	3.91	23.50	deleterious	0.64	0.7	0.3	neutral	0.43	neutral	0.59	disease	0.5	neutral	0	1	deleterious	0.12	neutral	-2	neutral	0.67	deleterious	-3.52	low_impact	-0.07	medium_impact	0.3	medium_impact	0.55	0.8	32.6	72.72	0.44	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8228	8228	C	T	MI.6562	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	643	215	P	S	Ccc/Tcc	-9.16	0	0	probably_damaging	1	neutral	0.66	neutral	2.11	neutral	0.76	deleterious	-6.35	neutral_impact	-0.3	0.42	damaging	0.31	neutral	2.86	21.70	deleterious	0.59	0.65	0.28	neutral	0.35	neutral	0.13	neutral	0.44	neutral	1	1	deleterious	0.33	neutral	-2	neutral	0.70	deleterious	-3.52	low_impact	0.36	medium_impact	-1.39	low_impact	0.19	0.8	23.35	40.36	0.42	N	0.28	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8228	8228	C	A	MI.6563	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	643	215	P	T	Ccc/Acc	-9.16	0	0	probably_damaging	1	neutral	0.56	neutral	1.95	neutral	-0.55	deleterious	-6.32	low_impact	1.25	0.38	damaging	0.21	damaging	3.76	23.30	deleterious	0.42	0.55	0.28	neutral	0.54	disease	0.17	neutral	0.46	neutral	1	1	deleterious	0.28	neutral	-2	neutral	0.72	deleterious	-3.52	low_impact	0.26	medium_impact	0.07	medium_impact	0.65	0.8	23.35	40.36	0.44	N	0.67	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8228	8228	C	G	MI.6564	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	643	215	P	A	Ccc/Gcc	-9.16	0	0	probably_damaging	0.99	neutral	0.74	neutral	1.92	neutral	-1.07	deleterious	-6.53	medium_impact	2.22	0.38	damaging	0.14	damaging	3.24	22.80	deleterious	0.48	0.55	0.26	neutral	0.54	disease	0.49	neutral	0.5	neutral	0	0.99	deleterious	0.38	neutral	1	deleterious	0.70	deleterious	-2.58	low_impact	0.46	medium_impact	0.98	medium_impact	0.73	0.85	23.35	40.36	0.41	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8229	8229	C	T	MI.6565	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	644	215	P	L	cCc/cTc	2.83	0.98	0	probably_damaging	1	neutral	0.77	neutral	1.87	neutral	-2.42	deleterious	-8.34	medium_impact	2.02	0.29	damaging	0.02	damaging	4.53	24.30	deleterious	0.43	0.55	0.56	disease	0.75	disease	0.49	neutral	0.58	disease	2	1	deleterious	0.39	neutral	1	deleterious	0.76	deleterious	-3.52	low_impact	0.5	medium_impact	0.79	medium_impact	0.72	0.85	23.35	40.36	0.62	P	0.89	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8229	8229	C	A	MI.6566	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	644	215	P	H	cCc/cAc	2.83	0.98	0	probably_damaging	1	neutral	0.59	neutral	1.87	neutral	-2.26	deleterious	-7.45	medium_impact	2.92	0.29	damaging	0.02	damaging	4.14	23.80	deleterious	0.4	0.5	0.73	disease	0.75	disease	0.57	disease	0.68	disease	4	1	deleterious	0.3	neutral	1	deleterious	0.79	deleterious	-3.52	low_impact	0.29	medium_impact	1.63	medium_impact	0.66	0.8	23.35	40.36	0.67	P	0.86	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8229	8229	C	G	MI.6567	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	644	215	P	R	cCc/cGc	2.83	0.98	0	probably_damaging	1	neutral	0.49	neutral	1.9	neutral	-1.43	deleterious	-7.51	medium_impact	2.92	0.22	damaging	0.02	damaging	3.78	23.40	deleterious	0.33	0.5	0.58	disease	0.85	disease	0.61	disease	0.74	disease	5	1	deleterious	0.25	neutral	1	deleterious	0.81	deleterious	-3.52	low_impact	0.2	medium_impact	1.63	medium_impact	0.64	0.8	23.35	40.36	0.72	P	0.93	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8231	8231	C	G	MI.6568	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	646	216	L	V	Cta/Gta	-14.47	0	0	possibly_damaging	0.89	neutral	0.54	neutral	1.94	neutral	-1.07	neutral	-2.15	low_impact	0.83	0.51	damaging	0.28	damaging	2.40	18.84	deleterious	0.56	0.6	0.72	disease	0.33	neutral	0.1	neutral	0.63	disease	3	0.88	neutral	0.33	neutral	-3	neutral	0.67	deleterious	-1.57	low_impact	0.24	medium_impact	-0.33	medium_impact	0.78	0.85	71.37	19.32	0.37	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8231	8231	C	A	MI.6569	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	646	216	L	M	Cta/Ata	-14.47	0	0	probably_damaging	0.99	neutral	0.23	neutral	1.88	neutral	-1.87	neutral	-1.64	low_impact	1.03	0.5	damaging	0.3	neutral	2.76	21.20	deleterious	0.44	0.55	0.81	disease	0.15	neutral	0.08	neutral	0.39	neutral	2	0.99	deleterious	0.12	neutral	-2	neutral	0.71	deleterious	-2.58	low_impact	-0.09	medium_impact	-0.14	medium_impact	0.81	0.85	71.37	19.32	0.44	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8836	8836	A	T	MI.657	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	310	104	M	L	Atg/Ttg	-10.05	0	0.01	possibly_damaging	0.81	neutral	1	neutral	5	neutral	2.39	neutral	-1.04	neutral_impact	-1.71	0.81	neutral	0.65	neutral	0.64	8.41	deleterious	0.42	0.65	0.57	disease	0.21	neutral	0.38	neutral	0.48	neutral	0	0.81	neutral	0.6	deleterious	-3	neutral	0.51	deleterious	-1.35	low_impact	1.98	high_impact	-2.56	low_impact	0.55	0.9	48.23	8.5	0.3	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8232	8232	T	A	MI.6570	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	647	216	L	Q	cTa/cAa	-0.17	0	0	probably_damaging	0.99	neutral	0.3	neutral	1.92	neutral	-0.2	deleterious	-5.31	low_impact	1.2	0.36	damaging	0.08	damaging	4.22	23.90	deleterious	0.24	0.45	0.66	disease	0.53	disease	0.25	neutral	0.49	neutral	0	0.99	deleterious	0.16	neutral	-2	neutral	0.76	deleterious	-2.58	low_impact	0	medium_impact	0.02	medium_impact	0.77	0.85	71.37	19.32	0.45	N	0.96	disease_causing	0.95	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8232	8232	T	C	MI.6571	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	647	216	L	P	cTa/cCa	-0.17	0	0	probably_damaging	1	neutral	0.23	neutral	1.96	neutral	-1.52	deleterious	-6.1	neutral_impact	-0.26	0.13	damaging	0.06	damaging	4.05	23.70	deleterious	0.36	0.5	0.58	disease	0.71	disease	0.24	neutral	0.51	disease	0	1	deleterious	0.12	neutral	-2	neutral	0.79	deleterious	-3.52	low_impact	-0.09	medium_impact	-1.35	low_impact	0.53	0.8	71.37	19.32	0.68	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8232	8232	T	G	MI.6572	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	647	216	L	R	cTa/cGa	-0.17	0	0	probably_damaging	0.99	neutral	0.35	neutral	1.91	neutral	-0.64	deleterious	-5.33	low_impact	1.48	0.16	damaging	0.06	damaging	4.30	24.00	deleterious	0.25	0.45	0.53	disease	0.81	disease	0.33	neutral	0.69	disease	4	0.99	deleterious	0.18	neutral	-2	neutral	0.79	deleterious	-2.58	low_impact	0.06	medium_impact	0.28	medium_impact	0.58	0.8	71.37	19.32	0.7	P	0.99	disease_causing	0.96	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8234	8234	A	G	MI.6573	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	649	217	K	E	Aaa/Gaa	-0.63	0	0	possibly_damaging	0.87	neutral	0.54	neutral	2.09	neutral	0.69	neutral	-0.6	neutral_impact	0.35	0.69	neutral	0.63	neutral	1.92	15.70	deleterious	0.27	0.45	0.25	neutral	0.6	disease	0.26	neutral	0.45	neutral	1	0.85	neutral	0.34	neutral	-3	neutral	0.66	deleterious	-1.49	low_impact	0.24	medium_impact	-0.78	medium_impact	0.63	0.8	61.67	17.69	0.31	N	0.92	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8234	8234	A	C	MI.6574	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	649	217	K	Q	Aaa/Caa	-0.63	0	0	possibly_damaging	0.86	neutral	0.45	neutral	1.93	neutral	-0.87	neutral	-0.88	low_impact	1.18	0.78	neutral	0.62	neutral	2.10	16.86	deleterious	0.33	0.5	0.58	disease	0.41	neutral	0.19	neutral	0.62	disease	2	0.85	neutral	0.3	neutral	-3	neutral	0.68	deleterious	-1.46	low_impact	0.16	medium_impact	0	medium_impact	0.75	0.85	61.67	17.69	0.41	N	0.84	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8235	8235	A	C	MI.6575	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	650	217	K	T	aAa/aCa	0.06	0	0	probably_damaging	0.96	neutral	0.54	neutral	1.92	neutral	-1.11	neutral	-2.1	low_impact	1.38	0.73	neutral	0.46	neutral	2.28	18.04	deleterious	0.22	0.45	0.59	disease	0.45	neutral	0.34	neutral	0.62	disease	2	0.95	neutral	0.29	neutral	-2	neutral	0.74	deleterious	-2.01	low_impact	0.24	medium_impact	0.19	medium_impact	0.59	0.8	61.67	17.69	0.25	N	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8235	8235	A	T	MI.6576	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	650	217	K	M	aAa/aTa	0.06	0	0	probably_damaging	0.98	neutral	0.24	neutral	1.86	deleterious	-4.02	deleterious	-2.67	medium_impact	3.08	0.57	damaging	0.21	damaging	3.81	23.40	deleterious	0.18	0.45	0.84	disease	0.47	neutral	0.46	neutral	0.64	disease	3	0.99	deleterious	0.13	neutral	1	deleterious	0.75	deleterious	-2.3	low_impact	-0.07	medium_impact	1.78	medium_impact	0.55	0.8	61.67	17.69	0.36	N	0.81	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8236	8236	A	C	MI.6577	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	651	217	K	N	aaA/aaC	0.98	0	0	probably_damaging	0.98	neutral	0.45	neutral	1.97	neutral	-0.34	neutral	-1.21	neutral_impact	0.56	0.66	neutral	0.55	neutral	1.78	14.84	neutral	0.49	0.55	0.57	disease	0.13	neutral	0.16	neutral	0.33	neutral	3	0.97	neutral	0.24	neutral	-2	neutral	0.69	deleterious	-2.3	low_impact	0.16	medium_impact	-0.58	medium_impact	0.66	0.8	61.67	17.69	0.43	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8236	8236	A	T	MI.6578	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	651	217	K	N	aaA/aaT	0.98	0	0	probably_damaging	0.98	neutral	0.45	neutral	1.97	neutral	-0.34	neutral	-1.21	neutral_impact	0.56	0.66	neutral	0.55	neutral	1.83	15.19	deleterious	0.49	0.55	0.57	disease	0.13	neutral	0.16	neutral	0.33	neutral	3	0.97	neutral	0.24	neutral	-2	neutral	0.69	deleterious	-2.3	low_impact	0.16	medium_impact	-0.58	medium_impact	0.66	0.8	61.67	17.69	0.43	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8237	8237	A	G	MI.6579	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	652	218	I	V	Atc/Gtc	-0.17	0	0	benign	0	neutral	0.5	neutral	2.01	neutral	0.55	neutral	0.06	neutral_impact	-0.49	0.8	neutral	0.58	neutral	0.02	2.81	deleterious	0.76	0.8	0.43	neutral	0.14	neutral	0.24	neutral	0.28	neutral	4	0.5	neutral	0.75	deleterious	-6	neutral	0.11	neutral	2.08	high_impact	0.21	medium_impact	-1.57	low_impact	0.58	0.8	34.36	63.36	0.37	N	0.50	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8836	8836	A	C	MI.658	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	310	104	M	L	Atg/Ctg	-10.05	0	0.01	possibly_damaging	0.81	neutral	1	neutral	5	neutral	2.39	neutral	-1.04	neutral_impact	-1.71	0.81	neutral	0.65	neutral	0.58	8.01	deleterious	0.42	0.65	0.57	disease	0.21	neutral	0.38	neutral	0.48	neutral	0	0.81	neutral	0.6	deleterious	-3	neutral	0.51	deleterious	-1.35	low_impact	1.98	high_impact	-2.56	low_impact	0.55	0.9	48.23	8.5	0.3	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8237	8237	A	T	MI.6580	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	652	218	I	F	Atc/Ttc	-0.17	0	0	benign	0.14	neutral	0.72	neutral	2	neutral	0.17	neutral	1.24	neutral_impact	-1.36	0.71	neutral	0.93	neutral	0.65	8.52	deleterious	0.64	0.7	0.27	neutral	0.27	neutral	0.12	neutral	0.42	neutral	2	0.16	neutral	0.79	deleterious	-6	neutral	0.23	neutral	0.01	medium_impact	0.43	medium_impact	-2.38	low_impact	0.65	0.8	34.36	63.36	0.37	N	0.42	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8237	8237	A	C	MI.6581	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	652	218	I	L	Atc/Ctc	-0.17	0	0	benign	0.01	neutral	0.67	neutral	2.02	neutral	0.9	neutral	-0.12	neutral_impact	-0.44	0.7	neutral	0.62	neutral	0.73	8.99	deleterious	0.68	0.7	0.29	neutral	0.22	neutral	0.19	neutral	0.39	neutral	2	0.31	neutral	0.83	deleterious	-6	neutral	0.10	neutral	1.14	medium_impact	0.38	medium_impact	-1.52	low_impact	0.59	0.8	34.36	63.36	0.43	N	0.44	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8238	8238	T	A	MI.6582	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	653	218	I	N	aTc/aAc	-2.94	0	0	possibly_damaging	0.5	neutral	0.33	neutral	2.08	neutral	2.06	neutral	3.12	neutral_impact	-2.04	0.73	neutral	0.88	neutral	1.66	14.17	neutral	0.47	0.55	0.26	neutral	0.3	neutral	0.16	neutral	0.43	neutral	1	0.64	neutral	0.42	neutral	-3	neutral	0.41	neutral	-0.72	medium_impact	0.04	medium_impact	-3.02	low_impact	0.49	0.8	34.36	63.36	0.46	N	0.19	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8238	8238	T	G	MI.6583	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	653	218	I	S	aTc/aGc	-2.94	0	0	benign	0.18	neutral	0.43	neutral	2.09	neutral	2.21	neutral	1.63	neutral_impact	-1.78	0.72	neutral	0.71	neutral	1.21	11.82	neutral	0.46	0.55	0.25	neutral	0.26	neutral	0.16	neutral	0.41	neutral	2	0.49	neutral	0.63	deleterious	-6	neutral	0.16	neutral	-0.11	medium_impact	0.14	medium_impact	-2.77	low_impact	0.39	0.8	34.36	63.36	0.45	N	0.50	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8238	8238	T	C	MI.6584	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	653	218	I	T	aTc/aCc	-2.94	0	0	benign	0.06	neutral	0.41	neutral	2.06	neutral	1.73	neutral	0.98	neutral_impact	-0.82	0.79	neutral	0.8	neutral	0.30	5.70	deleterious	0.51	0.6	0.31	neutral	0.11	neutral	0.15	neutral	0.28	neutral	4	0.55	neutral	0.68	deleterious	-6	neutral	0.12	neutral	0.39	medium_impact	0.12	medium_impact	-1.87	low_impact	0.39	0.8	34.36	63.36	0.48	N	0.45	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8239	8239	C	A	MI.6585	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	654	218	I	M	atC/atA	0.29	0	0	benign	0.32	neutral	0.23	neutral	1.99	neutral	-0.72	neutral	0.57	neutral_impact	-0.14	0.69	neutral	0.46	neutral	2.19	17.41	deleterious	0.78	0.8	0.58	disease	0.15	neutral	0.13	neutral	0.36	neutral	3	0.72	neutral	0.46	neutral	-6	neutral	0.27	neutral	-0.42	medium_impact	-0.09	medium_impact	-1.24	low_impact	0.75	0.85	34.36	63.36	0.53	N	0.63	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8239	8239	C	G	MI.6586	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	654	218	I	M	atC/atG	0.29	0	0	benign	0.32	neutral	0.23	neutral	1.99	neutral	-0.72	neutral	0.57	neutral_impact	-0.14	0.69	neutral	0.46	neutral	1.77	14.80	neutral	0.78	0.8	0.58	disease	0.15	neutral	0.13	neutral	0.36	neutral	3	0.72	neutral	0.46	neutral	-6	neutral	0.27	neutral	-0.42	medium_impact	-0.09	medium_impact	-1.24	low_impact	0.75	0.85	34.36	63.36	0.53	N	0.63	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8240	8240	T	C	MI.6587	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	655	219	F	L	Ttt/Ctt	-1.09	0	0	probably_damaging	0.98	neutral	0.69	neutral	1.23	deleterious	-4.45	deleterious	-5.33	medium_impact	3.48	0.31	damaging	0.48	neutral	4.16	23.80	deleterious	0.16	0.45	0.77	disease	0.79	disease	0.76	disease	0.78	disease	6	0.98	neutral	0.36	neutral	1	deleterious	0.82	deleterious	-2.3	low_impact	0.4	medium_impact	2.16	high_impact	0.54	0.8	67.84	19.2	0.68	P	0.80	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8240	8240	T	G	MI.6588	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	655	219	F	V	Ttt/Gtt	-1.09	0	0	probably_damaging	1	neutral	0.49	neutral	1.21	deleterious	-5.39	deleterious	-6.24	high_impact	4.72	0.3	damaging	0.4	neutral	4.10	23.70	deleterious	0.14	0.4	0.71	disease	0.88	disease	0.75	disease	0.81	disease	6	0.99	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.52	low_impact	0.2	medium_impact	3.32	high_impact	0.35	0.8	67.84	19.2	0.75	P	0.92	polymorphism	0.99	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8240	8240	T	A	MI.6589	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	655	219	F	I	Ttt/Att	-1.09	0	0	probably_damaging	0.99	neutral	0.4	neutral	1.2	deleterious	-5.85	deleterious	-5.41	high_impact	4.38	0.33	damaging	0.51	neutral	4.50	24.30	deleterious	0.12	0.4	0.58	disease	0.82	disease	0.77	disease	0.78	disease	6	0.99	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-2.58	low_impact	0.11	medium_impact	3	high_impact	0.34	0.8	67.84	19.2	0.69	P	0.88	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8837	8837	T	C	MI.659	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	311	104	M	T	aTg/aCg	0.36	0.03	0	probably_damaging	0.94	deleterious	0.04	neutral	4.24	neutral	-2.57	deleterious	-4.28	medium_impact	2.62	0.87	neutral	0.52	neutral	2.90	21.90	deleterious	0.37	0.65	0.71	disease	0.65	disease	0.64	disease	0.71	disease	4	0.99	deleterious	0.05	neutral	5	deleterious	0.78	deleterious	-1.89	low_impact	-0.49	medium_impact	1.15	medium_impact	0.44	0.9	48.23	8.5	0.39	N	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8241	8241	T	A	MI.6590	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	656	219	F	Y	tTt/tAt	7.44	1	0	probably_damaging	0.98	neutral	1	neutral	1.72	neutral	-0.76	deleterious	-2.79	medium_impact	2.04	0.33	damaging	0.35	neutral	4.34	24.10	deleterious	0.13	0.4	0.37	neutral	0.73	disease	0.62	disease	0.51	disease	0	0.98	deleterious	0.51	deleterious	1	deleterious	0.77	deleterious	-2.3	low_impact	1.86	high_impact	0.81	medium_impact	0.47	0.8	67.84	19.2	0.76	P	0.76	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8241	8241	T	C	MI.6591	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	656	219	F	S	tTt/tCt	7.44	1	0	probably_damaging	1	neutral	0.47	neutral	1.2	deleterious	-5.9	deleterious	-6.71	high_impact	4.03	0.28	damaging	0.5	neutral	4.38	24.10	deleterious	0.08	0.35	0.89	disease	0.85	disease	0.76	disease	0.84	disease	7	1	deleterious	0.24	neutral	2	deleterious	0.87	deleterious	-3.52	low_impact	0.18	medium_impact	2.67	high_impact	0.24	0.8	67.84	19.2	0.93	P	0.96	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8241	8241	T	G	MI.6592	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	656	219	F	C	tTt/tGt	7.44	1	0	probably_damaging	1	neutral	0.18	neutral	1.2	deleterious	-6.62	deleterious	-7.08	high_impact	4.72	0.3	damaging	0.39	neutral	4.23	23.90	deleterious	0.12	0.4	0.95	disease	0.83	disease	0.8	disease	0.87	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.52	low_impact	-0.16	medium_impact	3.32	high_impact	0.19	0.8	67.84	19.2	0.8	P	1.00	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8242	8242	T	A	MI.6593	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	657	219	F	L	ttT/ttA	7.44	1	0	probably_damaging	0.98	neutral	0.69	neutral	1.23	deleterious	-4.45	deleterious	-5.33	medium_impact	3.48	0.31	damaging	0.48	neutral	4.58	24.40	deleterious	0.16	0.45	0.77	disease	0.79	disease	0.76	disease	0.78	disease	6	0.98	neutral	0.36	neutral	1	deleterious	0.82	deleterious	-2.3	low_impact	0.4	medium_impact	2.16	high_impact	0.54	0.8	67.84	19.2	0.81	P	0.80	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8242	8242	T	G	MI.6594	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	657	219	F	L	ttT/ttG	7.44	1	0	probably_damaging	0.98	neutral	0.69	neutral	1.23	deleterious	-4.45	deleterious	-5.33	medium_impact	3.48	0.31	damaging	0.48	neutral	4.50	24.30	deleterious	0.16	0.45	0.77	disease	0.79	disease	0.76	disease	0.78	disease	6	0.98	neutral	0.36	neutral	1	deleterious	0.82	deleterious	-2.3	low_impact	0.4	medium_impact	2.16	high_impact	0.54	0.8	67.84	19.2	0.81	P	0.80	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8243	8243	G	A	MI.6595	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	658	220	E	K	Gaa/Aaa	-5.01	0	0	probably_damaging	0.94	neutral	0.3	neutral	2.53	neutral	-1.24	deleterious	-2.76	neutral_impact	-0.02	0.48	damaging	0.33	neutral	4.53	24.30	deleterious	0.42	0.55	0.25	neutral	0.74	disease	0.47	neutral	0.56	disease	1	0.95	neutral	0.18	neutral	-2	neutral	0.73	deleterious	-1.83	low_impact	0	medium_impact	-1.12	low_impact	0.75	0.85	NA	NA	0.35	N	0.99	polymorphism	0.97	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8243	8243	G	C	MI.6596	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	658	220	E	Q	Gaa/Caa	-5.01	0	0	probably_damaging	0.95	neutral	0.3	neutral	2.5	neutral	-1.49	neutral	-2.12	low_impact	0.84	0.59	damaging	0.69	neutral	2.27	17.99	deleterious	0.53	0.6	0.37	neutral	0.41	neutral	0.37	neutral	0.39	neutral	2	0.95	neutral	0.18	neutral	-2	neutral	0.69	deleterious	-1.91	low_impact	0	medium_impact	-0.32	medium_impact	0.68	0.85	NA	NA	0.39	N	0.76	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8244	8244	A	G	MI.6597	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	659	220	E	G	gAa/gGa	6.06	1	0	probably_damaging	0.98	neutral	0.33	neutral	2.43	neutral	-2.28	deleterious	-5.48	low_impact	1.32	0.52	damaging	0.51	neutral	4.41	24.10	deleterious	0.38	0.5	0.59	disease	0.6	disease	0.63	disease	0.67	disease	3	0.98	neutral	0.18	neutral	-2	neutral	0.74	deleterious	-2.3	low_impact	0.04	medium_impact	0.13	medium_impact	0.49	0.8	NA	NA	0.51	N	0.60	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8244	8244	A	C	MI.6598	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	659	220	E	A	gAa/gCa	6.06	1	0	probably_damaging	0.96	neutral	0.52	neutral	2.49	neutral	-1.68	deleterious	-4.48	neutral_impact	0.28	0.54	damaging	0.48	neutral	3.84	23.40	deleterious	0.35	0.5	0.45	neutral	0.55	disease	0.6	disease	0.65	disease	3	0.96	neutral	0.28	neutral	-2	neutral	0.72	deleterious	-2.01	low_impact	0.22	medium_impact	-0.84	medium_impact	0.68	0.85	NA	NA	0.47	N	0.65	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8244	8244	A	T	MI.6599	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	659	220	E	V	gAa/gTa	6.06	1	0	probably_damaging	0.97	neutral	0.5	neutral	2.45	neutral	-2.96	deleterious	-5.01	neutral_impact	0.14	0.51	damaging	0.42	neutral	4.40	24.10	deleterious	0.28	0.45	0.68	disease	0.77	disease	0.65	disease	0.69	disease	4	0.97	neutral	0.27	neutral	-2	neutral	0.78	deleterious	-2.13	low_impact	0.21	medium_impact	-0.97	medium_impact	0.77	0.85	NA	NA	0.48	N	0.81	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8555	8555	T	C	MI.66	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	29	10	I	T	aTt/aCt	-3.11	0	0	benign	0	neutral	0.12	neutral	4.73	neutral	-0.08	neutral	-0.17	neutral_impact	0.74	0.95	neutral	0.96	neutral	0.03	2.91	deleterious	0.39	0.65	0.21	neutral	0.29	neutral	0.23	neutral	0.43	neutral	1	0.88	neutral	0.56	deleterious	-6	neutral	0.08	neutral	2.09	high_impact	-0.2	medium_impact	-0.46	medium_impact	0.24	0.9	27.43	16.7	0.47	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8837	8837	T	A	MI.660	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	311	104	M	K	aTg/aAg	0.36	0.03	0	probably_damaging	0.94	deleterious	0	neutral	4.22	deleterious	-3.92	deleterious	-4.67	medium_impact	2.62	0.85	neutral	0.39	neutral	4.01	23.60	deleterious	0.13	0.65	0.85	disease	0.82	disease	0.71	disease	0.74	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.83	deleterious	-1.89	low_impact	-1.4	low_impact	1.15	medium_impact	0.40	0.9	48.23	8.5	0.31	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8245	8245	A	T	MI.6600	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	660	220	E	D	gaA/gaT	8.59	1	0	possibly_damaging	0.8	neutral	0.22	neutral	2.52	neutral	-0.14	neutral	-2.36	neutral_impact	0.08	0.56	damaging	0.39	neutral	3.90	23.50	deleterious	0.43	0.55	0.26	neutral	0.54	disease	0.48	neutral	0.46	neutral	1	0.87	neutral	0.21	neutral	-3	neutral	0.59	deleterious	-1.28	low_impact	-0.1	medium_impact	-1.03	low_impact	0.82	0.85	NA	NA	0.59	P	0.82	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8245	8245	A	C	MI.6601	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	660	220	E	D	gaA/gaC	8.59	1	0	possibly_damaging	0.8	neutral	0.22	neutral	2.52	neutral	-0.14	neutral	-2.36	neutral_impact	0.08	0.56	damaging	0.39	neutral	3.75	23.30	deleterious	0.43	0.55	0.26	neutral	0.54	disease	0.48	neutral	0.46	neutral	1	0.87	neutral	0.21	neutral	-3	neutral	0.59	deleterious	-1.28	low_impact	-0.1	medium_impact	-1.03	low_impact	0.82	0.85	NA	NA	0.58	P	0.82	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8246	8246	A	C	MI.6602	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	661	221	M	L	Ata/Cta	0.75	0.14	0	possibly_damaging	0.7	neutral	0.67	neutral	2.64	neutral	1.27	neutral	-0.69	neutral_impact	-0.8	0.82	neutral	0.75	neutral	-0.80	0.04	neutral	0.53	0.6	0.39	neutral	0.1	neutral	0.17	neutral	0.06	neutral	9	0.64	neutral	0.49	deleterious	-3	neutral	0.41	neutral	-1.06	low_impact	0.38	medium_impact	-1.86	low_impact	0.71	0.85	33.04	90.86	0.39	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8246	8246	A	T	MI.6603	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	661	221	M	L	Ata/Tta	0.75	0.14	0	possibly_damaging	0.7	neutral	0.67	neutral	2.64	neutral	1.27	neutral	-0.69	neutral_impact	-0.8	0.82	neutral	0.75	neutral	-0.73	0.06	neutral	0.53	0.6	0.39	neutral	0.1	neutral	0.17	neutral	0.06	neutral	9	0.64	neutral	0.49	deleterious	-3	neutral	0.41	neutral	-1.06	low_impact	0.38	medium_impact	-1.86	low_impact	0.71	0.85	33.04	90.86	0.39	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8246	8246	A	G	MI.6604	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	661	221	M	V	Ata/Gta	0.75	0.14	0	possibly_damaging	0.79	neutral	0.52	neutral	2.63	neutral	0.97	neutral	-0.53	neutral_impact	-0.52	0.83	neutral	0.82	neutral	-1.80	0.00	neutral	0.4	0.5	0.57	disease	0.18	neutral	0.2	neutral	0.08	neutral	8	0.76	neutral	0.37	neutral	-3	neutral	0.50	deleterious	-1.26	low_impact	0.22	medium_impact	-1.59	low_impact	0.76	0.85	33.04	90.86	0.36	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8247	8247	T	C	MI.6605	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	662	221	M	T	aTa/aCa	0.06	0	0	possibly_damaging	0.9	neutral	0.43	neutral	2.61	neutral	0.48	neutral	1.4	neutral_impact	0.65	0.82	neutral	0.85	neutral	-1.22	0.01	neutral	0.39	0.5	0.39	neutral	0.24	neutral	0.28	neutral	0.18	neutral	6	0.89	neutral	0.27	neutral	-3	neutral	0.61	deleterious	-1.61	low_impact	0.14	medium_impact	-0.5	medium_impact	0.31	0.8	33.04	90.86	0.32	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8247	8247	T	A	MI.6606	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	662	221	M	K	aTa/aAa	0.06	0	0	possibly_damaging	0.9	neutral	0.37	neutral	2.64	neutral	0.93	neutral	1.51	low_impact	1.2	0.8	neutral	0.83	neutral	0.15	4.19	deleterious	0.32	0.5	0.4	neutral	0.48	neutral	0.5	neutral	0.32	neutral	4	0.9	neutral	0.24	neutral	-3	neutral	0.63	deleterious	-1.61	low_impact	0.08	medium_impact	0.02	medium_impact	0.68	0.85	33.04	90.86	0.31	N	0.27	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8248	8248	A	T	MI.6607	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	663	221	M	I	atA/atT	-0.17	0	0	possibly_damaging	0.84	neutral	0.41	neutral	2.6	neutral	0.71	neutral	-0.76	neutral_impact	-1.01	0.82	neutral	0.84	neutral	-0.13	1.52	neutral	0.5	0.6	0.66	disease	0.2	neutral	0.17	neutral	0.15	neutral	7	0.84	neutral	0.29	neutral	-3	neutral	0.59	deleterious	-1.39	low_impact	0.12	medium_impact	-2.05	low_impact	0.77	0.85	33.04	90.86	0.42	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8248	8248	A	C	MI.6608	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	663	221	M	I	atA/atC	-0.17	0	0	possibly_damaging	0.84	neutral	0.41	neutral	2.6	neutral	0.71	neutral	-0.76	neutral_impact	-1.01	0.82	neutral	0.84	neutral	-0.31	0.64	neutral	0.5	0.6	0.66	disease	0.2	neutral	0.17	neutral	0.15	neutral	7	0.84	neutral	0.29	neutral	-3	neutral	0.59	deleterious	-1.39	low_impact	0.12	medium_impact	-2.05	low_impact	0.77	0.85	33.04	90.86	0.42	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8249	8249	G	T	MI.6609	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	664	222	G	W	Ggg/Tgg	-0.63	0	0	probably_damaging	1	neutral	0.28	neutral	2.53	neutral	-2.68	neutral	11.25	low_impact	0.9	0.72	neutral	0.77	neutral	1.79	14.94	neutral	0.13	0.4	0.63	disease	0.11	neutral	0.4	neutral	0.05	neutral	9	1	deleterious	0.14	neutral	-2	neutral	0.71	deleterious	-3.52	low_impact	-0.02	medium_impact	-0.26	medium_impact	0.38	0.8	28.63	77.15	0.45	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8838	8838	G	T	MI.661	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	312	104	M	I	atG/atT	7.53	0.97	0	probably_damaging	0.91	neutral	0.18	neutral	4.39	neutral	0.02	neutral	-2.09	neutral_impact	0.5	0.85	neutral	0.57	neutral	2.48	19.35	deleterious	0.51	0.65	0.53	disease	0.63	disease	0.45	neutral	0.36	neutral	3	0.95	neutral	0.14	neutral	-2	neutral	0.72	deleterious	-1.71	low_impact	-0.08	medium_impact	-0.67	medium_impact	0.70	0.9	48.23	8.5	0.48	N	0.91	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8249	8249	G	C	MI.6610	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	664	222	G	R	Ggg/Cgg	-0.63	0	0	probably_damaging	1	neutral	0.34	neutral	2.59	neutral	-0.85	neutral	-0.86	neutral_impact	0.2	0.6	damaging	0.51	neutral	2.97	22.10	deleterious	0.13	0.4	0.39	neutral	0.77	disease	0.56	disease	0.67	disease	3	1	deleterious	0.17	neutral	-2	neutral	0.81	deleterious	-3.52	low_impact	0.05	medium_impact	-0.92	medium_impact	0.47	0.8	28.63	77.15	0.33	N	0.78	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8250	8250	G	A	MI.6611	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	665	222	G	E	gGg/gAg	5.36	1	0	probably_damaging	1	neutral	0.28	neutral	2.6	neutral	-0.71	neutral	-0.83	neutral_impact	-0.2	0.64	neutral	0.54	neutral	3.29	22.80	deleterious	0.18	0.45	0.37	neutral	0.68	disease	0.54	disease	0.59	disease	2	1	deleterious	0.14	neutral	-2	neutral	0.77	deleterious	-3.52	low_impact	-0.02	medium_impact	-1.29	low_impact	0.39	0.8	28.63	77.15	0.42	N	0.86	disease_causing	0.88	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8250	8250	G	C	MI.6612	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	665	222	G	A	gGg/gCg	5.36	1	0	probably_damaging	1	neutral	0.51	neutral	2.64	neutral	-0.1	neutral	-0.6	neutral_impact	-0.38	0.66	neutral	0.61	neutral	2.24	17.79	deleterious	0.21	0.45	0.32	neutral	0.37	neutral	0.29	neutral	0.15	neutral	7	1	deleterious	0.26	neutral	-2	neutral	0.72	deleterious	-3.52	low_impact	0.21	medium_impact	-1.46	low_impact	0.38	0.8	28.63	77.15	0.44	N	0.49	disease_causing	0.74	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8250	8250	G	T	MI.6613	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	665	222	G	V	gGg/gTg	5.36	1	0	probably_damaging	1	neutral	0.53	neutral	2.63	neutral	-0.62	neutral	-0.82	neutral_impact	0.2	0.6	damaging	0.54	neutral	4.09	23.70	deleterious	0.15	0.4	0.3	neutral	0.64	disease	0.41	neutral	0.48	neutral	0	1	deleterious	0.27	neutral	-2	neutral	0.74	deleterious	-3.52	low_impact	0.23	medium_impact	-0.92	medium_impact	0.41	0.8	28.63	77.15	0.41	N	0.70	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8252	8252	C	T	MI.6614	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	667	223	P	S	Ccc/Tcc	3.52	1	0	benign	0.17	neutral	0.51	neutral	2.66	neutral	0.05	neutral	2.77	neutral_impact	-1.86	0.84	neutral	0.85	neutral	-0.29	0.72	neutral	0.46	0.55	0.37	neutral	0.04	neutral	0.17	neutral	0.05	neutral	9	0.39	neutral	0.67	deleterious	-6	neutral	0.21	neutral	-0.08	medium_impact	0.21	medium_impact	-2.85	low_impact	0.15	0.8	32.16	9.43	0.49	N	0.04	polymorphism	0.78	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8252	8252	C	G	MI.6615	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	667	223	P	A	Ccc/Gcc	3.52	1	0	benign	0.01	neutral	0.59	neutral	2.68	neutral	0.35	neutral	1.41	neutral_impact	-1.24	0.87	neutral	0.85	neutral	-0.03	2.34	deleterious	0.36	0.5	0.24	neutral	0.14	neutral	0.37	neutral	0.1	neutral	8	0.4	neutral	0.79	deleterious	-6	neutral	0.09	neutral	1.14	medium_impact	0.29	medium_impact	-2.27	low_impact	0.83	0.9	32.16	9.43	0.45	N	0.29	polymorphism	0.85	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8252	8252	C	A	MI.6616	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	667	223	P	T	Ccc/Acc	3.52	1	0	benign	0.17	neutral	0.46	neutral	2.63	neutral	-0.32	neutral	2.01	neutral_impact	-1.24	0.82	neutral	0.81	neutral	-0.48	0.25	neutral	0.43	0.55	0.26	neutral	0.11	neutral	0.39	neutral	0.05	neutral	9	0.45	neutral	0.65	deleterious	-6	neutral	0.21	neutral	-0.08	medium_impact	0.17	medium_impact	-2.27	low_impact	0.72	0.85	32.16	9.43	0.52	N	0.36	polymorphism	0.78	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8253	8253	C	G	MI.6617	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	668	223	P	R	cCc/cGc	2.44	1	0	possibly_damaging	0.6	neutral	0.41	neutral	2.62	neutral	-0.61	neutral	-0.16	neutral_impact	-0.55	0.79	neutral	0.76	neutral	1.24	11.96	neutral	0.37	0.5	0.23	neutral	0.5	neutral	0.58	disease	0.58	disease	2	0.63	neutral	0.41	neutral	-3	neutral	0.47	deleterious	-0.89	medium_impact	0.12	medium_impact	-1.62	low_impact	0.68	0.85	32.16	9.43	0.36	N	0.71	polymorphism	0.96	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8253	8253	C	T	MI.6618	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	668	223	P	L	cCc/cTc	2.44	1	0	benign	0.17	neutral	0.69	neutral	2.68	neutral	-0.09	neutral	0.4	neutral_impact	-0.9	0.9	neutral	0.8	neutral	1.83	15.15	deleterious	0.49	0.55	0.35	neutral	0.29	neutral	0.42	neutral	0.14	neutral	7	0.19	neutral	0.76	deleterious	-6	neutral	0.24	neutral	-0.08	medium_impact	0.4	medium_impact	-1.95	low_impact	0.74	0.85	32.16	9.43	0.42	N	0.80	disease_causing	0.91	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8253	8253	C	A	MI.6619	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	668	223	P	H	cCc/cAc	2.44	1	0	possibly_damaging	0.82	neutral	0.55	neutral	2.57	neutral	-1.8	neutral	-0.3	neutral_impact	-0.34	0.82	neutral	0.75	neutral	4.09	23.70	deleterious	0.38	0.5	0.46	neutral	0.29	neutral	0.62	disease	0.14	neutral	7	0.79	neutral	0.37	neutral	-3	neutral	0.59	deleterious	-1.33	low_impact	0.25	medium_impact	-1.42	low_impact	0.68	0.85	32.16	9.43	0.35	N	0.73	polymorphism	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8838	8838	G	C	MI.662	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	312	104	M	I	atG/atC	7.53	0.97	0	probably_damaging	0.91	neutral	0.18	neutral	4.39	neutral	0.02	neutral	-2.09	neutral_impact	0.5	0.85	neutral	0.57	neutral	2.38	18.69	deleterious	0.51	0.65	0.53	disease	0.63	disease	0.45	neutral	0.36	neutral	3	0.95	neutral	0.14	neutral	-2	neutral	0.72	deleterious	-1.71	low_impact	-0.08	medium_impact	-0.67	medium_impact	0.70	0.9	48.23	8.5	0.47	N	0.91	polymorphism	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8255	8255	G	T	MI.6620	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	670	224	V	L	Gta/Tta	-10.75	0	0	probably_damaging	0.96	neutral	0.7	neutral	2.57	neutral	-0.19	neutral	-0.12	neutral_impact	-0.34	0.88	neutral	0.7	neutral	2.35	18.52	deleterious	0.47	0.55	0.22	neutral	0.13	neutral	0.3	neutral	0.06	neutral	9	0.96	neutral	0.37	neutral	-2	neutral	0.59	deleterious	-2.01	low_impact	0.41	medium_impact	-1.42	low_impact	0.66	0.8	31.72	62.66	0.33	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8255	8255	G	C	MI.6621	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	670	224	V	L	Gta/Cta	-10.75	0	0	probably_damaging	0.96	neutral	0.7	neutral	2.57	neutral	-0.19	neutral	-0.12	neutral_impact	-0.34	0.88	neutral	0.7	neutral	2.26	17.93	deleterious	0.47	0.55	0.22	neutral	0.13	neutral	0.3	neutral	0.06	neutral	9	0.96	neutral	0.37	neutral	-2	neutral	0.59	deleterious	-2.01	low_impact	0.41	medium_impact	-1.42	low_impact	0.66	0.8	31.72	62.66	0.23	N	0.42	polymorphism	1	0.01	rs201246560	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8255	8255	G	A	MI.6622	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	670	224	V	M	Gta/Ata	-10.75	0	0	probably_damaging	1	neutral	0.23	neutral	2.45	neutral	-2.16	neutral	0.06	neutral_impact	-0.85	0.88	neutral	0.81	neutral	2.88	21.80	deleterious	0.41	0.5	0.53	disease	0.19	neutral	0.34	neutral	0.12	neutral	8	1	deleterious	0.12	neutral	-2	neutral	0.64	deleterious	-3.52	low_impact	-0.09	medium_impact	-1.9	low_impact	0.62	0.8	31.72	62.66	0.48	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8256	8256	T	C	MI.6623	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	671	224	V	A	gTa/gCa	-2.65	0	0	probably_damaging	0.98	neutral	0.62	neutral	2.55	neutral	-0.53	neutral	0.85	neutral_impact	0.34	0.89	neutral	0.86	neutral	2.23	17.69	deleterious	0.47	0.55	0.38	neutral	0.17	neutral	0.37	neutral	0.12	neutral	8	0.97	neutral	0.32	neutral	-2	neutral	0.62	deleterious	-2.3	low_impact	0.32	medium_impact	-0.79	medium_impact	0.55	0.8	31.72	62.66	0.31	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8256	8256	T	G	MI.6624	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	671	224	V	G	gTa/gGa	-2.65	0	0	probably_damaging	0.99	neutral	0.39	neutral	2.46	neutral	-1.48	neutral	-0.27	neutral_impact	0.7	0.77	neutral	0.83	neutral	4.12	23.80	deleterious	0.3	0.45	0.5	disease	0.32	neutral	0.44	neutral	0.16	neutral	7	0.99	deleterious	0.2	neutral	-2	neutral	0.66	deleterious	-2.58	low_impact	0.1	medium_impact	-0.45	medium_impact	0.63	0.8	31.72	62.66	0.36	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8256	8256	T	A	MI.6625	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	671	224	V	E	gTa/gAa	-2.65	0	0	probably_damaging	0.99	neutral	0.42	neutral	2.47	neutral	-1.5	neutral	0.12	neutral_impact	0.7	0.8	neutral	0.83	neutral	3.85	23.40	deleterious	0.26	0.45	0.26	neutral	0.48	neutral	0.49	neutral	0.32	neutral	4	0.99	deleterious	0.22	neutral	-2	neutral	0.65	deleterious	-2.58	low_impact	0.13	medium_impact	-0.45	medium_impact	0.66	0.8	31.72	62.66	0.3	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8258	8258	T	A	MI.6626	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	673	225	F	I	Ttt/Att	-5.42	0	0	benign	0.05	neutral	0.42	neutral	2.59	neutral	-0.01	neutral	0.35	neutral_impact	0.77	0.8	neutral	0.8	neutral	1.44	13.02	neutral	0.51	0.6	0.28	neutral	0.36	neutral	0.34	neutral	0.14	neutral	7	0.54	neutral	0.69	deleterious	-6	neutral	0.17	neutral	0.47	medium_impact	0.13	medium_impact	-0.38	medium_impact	0.59	0.8	35.24	88.5	0.34	N	0.27	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8258	8258	T	G	MI.6627	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	673	225	F	V	Ttt/Gtt	-5.42	0	0	benign	0.08	neutral	0.52	neutral	2.6	neutral	0.15	neutral	0.29	low_impact	1.32	0.8	neutral	0.81	neutral	1.21	11.82	neutral	0.46	0.55	0.37	neutral	0.46	neutral	0.36	neutral	0.19	neutral	6	0.41	neutral	0.72	deleterious	-6	neutral	0.19	neutral	0.27	medium_impact	0.22	medium_impact	0.13	medium_impact	0.68	0.85	35.24	88.5	0.3	N	0.37	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8258	8258	T	C	MI.6628	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	673	225	F	L	Ttt/Ctt	-5.42	0	0	benign	0	neutral	0.71	neutral	2.67	neutral	0.62	neutral	1.04	neutral_impact	0.17	0.89	neutral	0.82	neutral	-0.40	0.39	neutral	0.54	0.6	0.31	neutral	0.06	neutral	0.13	neutral	0.06	neutral	9	0.28	neutral	0.86	deleterious	-6	neutral	0.07	neutral	2.08	high_impact	0.42	medium_impact	-0.95	medium_impact	0.64	0.8	35.24	88.5	0.47	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8259	8259	T	A	MI.6629	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	674	225	F	Y	tTt/tAt	-0.33	0	0	benign	0.2	neutral	1	neutral	2.54	neutral	-0.86	neutral	-0.19	low_impact	1.32	0.82	neutral	0.88	neutral	2.81	21.40	deleterious	0.56	0.6	0.52	disease	0.33	neutral	0.35	neutral	0.16	neutral	7	0.2	neutral	0.9	deleterious	-6	neutral	0.40	neutral	-0.16	medium_impact	1.86	high_impact	0.13	medium_impact	0.60	0.8	35.24	88.5	0.26	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8839	8839	G	T	MI.663	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	313	105	A	S	Gcc/Tcc	-2.19	0	0.01	probably_damaging	0.99	neutral	0.31	neutral	3.27	neutral	-1.92	deleterious	-2.63	low_impact	1.7	0.52	damaging	0.48	neutral	3.64	23.20	deleterious	0.27	0.65	0.42	neutral	0.73	disease	0.54	disease	0.44	neutral	1	0.99	deleterious	0.16	neutral	-2	neutral	0.78	deleterious	-2.65	low_impact	0.1	medium_impact	0.36	medium_impact	0.71	0.9	49.12	8.67	0.37	N	0.95	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8259	8259	T	C	MI.6630	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	674	225	F	S	tTt/tCt	-0.33	0	0	benign	0.41	neutral	0.45	neutral	2.54	neutral	-0.64	neutral	1.4	low_impact	1.32	0.84	neutral	0.9	neutral	2.93	22.00	deleterious	0.5	0.6	0.33	neutral	0.43	neutral	0.28	neutral	0.19	neutral	6	0.49	neutral	0.52	deleterious	-6	neutral	0.41	neutral	-0.57	medium_impact	0.16	medium_impact	0.13	medium_impact	0.45	0.8	35.24	88.5	0.35	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8259	8259	T	G	MI.6631	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	674	225	F	C	tTt/tGt	-0.33	0	0	possibly_damaging	0.77	neutral	0.19	neutral	2.48	neutral	-2.64	neutral	-0.51	low_impact	1.32	0.71	neutral	0.74	neutral	4.20	23.90	deleterious	0.42	0.55	0.71	disease	0.48	neutral	0.46	neutral	0.38	neutral	2	0.87	neutral	0.21	neutral	-3	neutral	0.61	deleterious	-1.21	low_impact	-0.14	medium_impact	0.13	medium_impact	0.50	0.8	35.24	88.5	0.42	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8260	8260	T	A	MI.6632	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	675	225	F	L	ttT/ttA	-0.1	0	0	benign	0	neutral	0.71	neutral	2.67	neutral	0.62	neutral	1.04	neutral_impact	0.17	0.89	neutral	0.82	neutral	0.03	2.91	deleterious	0.54	0.6	0.31	neutral	0.06	neutral	0.13	neutral	0.06	neutral	9	0.28	neutral	0.86	deleterious	-6	neutral	0.07	neutral	2.08	high_impact	0.42	medium_impact	-0.95	medium_impact	0.64	0.8	35.24	88.5	0.48	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8260	8260	T	G	MI.6633	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	675	225	F	L	ttT/ttG	-0.1	0	0	benign	0	neutral	0.71	neutral	2.67	neutral	0.62	neutral	1.04	neutral_impact	0.17	0.89	neutral	0.82	neutral	-0.08	1.86	neutral	0.54	0.6	0.31	neutral	0.06	neutral	0.13	neutral	0.06	neutral	9	0.28	neutral	0.86	deleterious	-6	neutral	0.07	neutral	2.08	high_impact	0.42	medium_impact	-0.95	medium_impact	0.64	0.8	35.24	88.5	0.48	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8261	8261	A	C	MI.6634	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	676	226	T	P	Acc/Ccc	-2.88	0	0	benign	0.3	neutral	0.22	neutral	2.51	neutral	-1.74	neutral	-1.18	neutral_impact	0	0.7	neutral	0.74	neutral	1.99	16.16	deleterious	0.43	0.55	0.8	disease	0.38	neutral	0.57	disease	0.25	neutral	5	0.74	neutral	0.46	neutral	-6	neutral	0.43	neutral	-0.38	medium_impact	-0.1	medium_impact	-1.11	low_impact	0.68	0.85	NA	NA	0.37	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8261	8261	A	T	MI.6635	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	676	226	T	S	Acc/Tcc	-2.88	0	0	benign	0.07	neutral	0.42	neutral	2.59	neutral	-0.17	neutral	-0.31	neutral_impact	-0.8	0.8	neutral	0.87	neutral	0.47	7.21	deleterious	0.76	0.8	0.59	disease	0.08	neutral	0.39	neutral	0.04	neutral	9	0.53	neutral	0.68	deleterious	-6	neutral	0.17	neutral	0.33	medium_impact	0.13	medium_impact	-1.86	low_impact	0.81	0.85	NA	NA	0.38	N	0.19	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8261	8261	A	G	MI.6636	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	676	226	T	A	Acc/Gcc	-2.88	0	0	benign	0	neutral	0.52	neutral	2.63	neutral	0.15	neutral	-0.19	neutral_impact	-0.34	0.9	neutral	0.92	neutral	0.52	7.57	deleterious	0.74	0.8	0.4	neutral	0.14	neutral	0.39	neutral	0.11	neutral	8	0.47	neutral	0.76	deleterious	-6	neutral	0.11	neutral	2.08	high_impact	0.22	medium_impact	-1.42	low_impact	0.65	0.8	NA	NA	0.4	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8262	8262	C	G	MI.6637	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	677	226	T	S	aCc/aGc	2.9	0.89	0	benign	0.07	neutral	0.42	neutral	2.59	neutral	-0.17	neutral	-0.31	neutral_impact	-0.8	0.8	neutral	0.87	neutral	0.71	8.87	deleterious	0.76	0.8	0.59	disease	0.08	neutral	0.39	neutral	0.04	neutral	9	0.53	neutral	0.68	deleterious	-6	neutral	0.17	neutral	0.33	medium_impact	0.13	medium_impact	-1.86	low_impact	0.81	0.85	NA	NA	0.38	N	0.19	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8262	8262	C	T	MI.6638	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	677	226	T	I	aCc/aTc	2.9	0.89	0	benign	0.18	neutral	0.39	neutral	2.58	neutral	-0.38	neutral	1.15	neutral_impact	0	0.86	neutral	0.86	neutral	0.69	8.75	deleterious	0.71	0.75	0.63	disease	0.31	neutral	0.28	neutral	0.22	neutral	6	0.53	neutral	0.61	deleterious	-6	neutral	0.25	neutral	-0.11	medium_impact	0.1	medium_impact	-1.11	low_impact	0.67	0.85	NA	NA	0.33	N	0.18	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8262	8262	C	A	MI.6639	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	677	226	T	N	aCc/aAc	2.9	0.89	0	benign	0.3	neutral	0.32	neutral	2.54	neutral	-1.11	neutral	-1	neutral_impact	-0.98	0.78	neutral	0.83	neutral	2.08	16.70	deleterious	0.67	0.7	0.54	disease	0.3	neutral	0.45	neutral	0.19	neutral	6	0.61	neutral	0.51	deleterious	-6	neutral	0.31	neutral	-0.38	medium_impact	0.02	medium_impact	-2.02	low_impact	0.74	0.85	NA	NA	0.34	N	0.45	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8839	8839	G	C	MI.664	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	313	105	A	P	Gcc/Ccc	-2.19	0	0.01	probably_damaging	1	deleterious	0	neutral	2.97	deleterious	-6.3	deleterious	-4.63	high_impact	3.97	0.41	damaging	0.4	neutral	3.76	23.30	deleterious	0.13	0.65	0.95	disease	0.9	disease	0.76	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.3	high_impact	0.58	0.9	49.12	8.67	0.57	P	0.97	disease_causing_automatic	1	0.35	rs369202065	Pathogenic	Leigh_syndrome|Mitochondrial_diseases	165641	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C0751651,Orphanet:ORPHA68380	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	8264	8264	C	G	MI.6640	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	679	227	L	V	Cta/Gta	-0.8	0	0	probably_damaging	0.98	neutral	0.62	neutral	2.52	neutral	-0.72	neutral	-1.19	neutral_impact	0	0.7	neutral	0.52	neutral	3.58	23.20	deleterious	0.46	0.55	NA	NA	0.17	neutral	0.38	neutral	0.23	neutral	5	0.97	neutral	0.32	neutral	-2	neutral	0.87	deleterious	-2.3	low_impact	0.32	medium_impact	-1.11	low_impact	0.84	0.9	NA	NA	0.26	N	0.12	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8264	8264	C	A	MI.6641	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	679	227	L	M	Cta/Ata	-0.8	0	0	probably_damaging	1	neutral	0.26	neutral	2.43	neutral	-2.4	neutral	-0.63	neutral_impact	0	0.74	neutral	0.52	neutral	2.70	20.80	deleterious	0.31	0.45	NA	NA	0.13	neutral	0.33	neutral	0.18	neutral	6	1	deleterious	0.13	neutral	-2	neutral	0.88	deleterious	-3.52	low_impact	-0.05	medium_impact	-1.11	low_impact	0.63	0.8	NA	NA	0.42	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8265	8265	T	G	MI.6642	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	680	227	L	R	cTa/cGa	-3.11	0	0	probably_damaging	1	neutral	0.34	neutral	2.46	neutral	-1.8	deleterious	-2.62	neutral_impact	0	0.6	damaging	0.46	neutral	4.36	24.10	deleterious	0.31	0.45	NA	NA	0.48	neutral	0.62	disease	0.34	neutral	3	1	deleterious	0.17	neutral	-2	neutral	0.90	deleterious	-3.52	low_impact	0.05	medium_impact	-1.11	low_impact	0.58	0.8	NA	NA	0.27	N	0.51	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8265	8265	T	C	MI.6643	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	680	227	L	P	cTa/cCa	-3.11	0	0	probably_damaging	1	neutral	0.2	neutral	2.43	neutral	-2.71	deleterious	-2.54	neutral_impact	0	0.56	damaging	0.42	neutral	4.07	23.70	deleterious	0.34	0.5	NA	NA	0.31	neutral	0.53	disease	0.21	neutral	6	1	deleterious	0.1	neutral	-2	neutral	0.90	deleterious	-3.52	low_impact	-0.13	medium_impact	-1.11	low_impact	0.45	0.8	NA	NA	0.35	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8265	8265	T	A	MI.6644	MT-CO2	IV	ENSG00000198712	ENSP00000354876	ENST00000361739	COX2_HUMAN	P00403	4513	YP_003024029.1	680	227	L	Q	cTa/cAa	-3.11	0	0	probably_damaging	1	neutral	0.33	neutral	2.44	neutral	-2.21	neutral	-2.05	neutral_impact	0	0.68	neutral	0.52	neutral	4.23	23.90	deleterious	0.32	0.5	NA	NA	0.31	neutral	0.56	disease	0.21	neutral	6	1	deleterious	0.17	neutral	-2	neutral	0.89	deleterious	-3.52	low_impact	0.04	medium_impact	-1.11	low_impact	0.65	0.8	NA	NA	0.3	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9207	9207	A	C	MI.6645	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	1	1	M	L	Atg/Ctg	6.61	1	0	benign	0.42	deleterious	0	neutral	2.58	neutral	1.29	neutral	-1.85	NA	NA	0.53	damaging	0.1	damaging	3.11	22.50	deleterious	0.07	0.35	NA	NA	0.15	neutral	0.35	neutral	0.21	neutral	6	1	deleterious	0.29	neutral	0	NA	0.36	neutral	NA	NA	NA	NA	NA	NA	0.34	0.8	74.33	11.77	0.6	P	0.94	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9207	9207	A	T	MI.6646	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	1	1	M	L	Atg/Ttg	6.61	1	0	benign	0.42	deleterious	0	neutral	2.58	neutral	1.29	neutral	-1.85	NA	NA	0.53	damaging	0.1	damaging	3.09	22.50	deleterious	0.07	0.35	NA	NA	0.15	neutral	0.35	neutral	0.21	neutral	6	1	deleterious	0.29	neutral	0	NA	0.36	neutral	NA	NA	NA	NA	NA	NA	0.34	0.8	74.33	11.77	0.61	P	0.94	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9207	9207	A	G	MI.6647	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	1	1	M	V	Atg/Gtg	6.61	1	0	possibly_damaging	0.54	deleterious	0	neutral	2.55	neutral	0.83	neutral	-2.46	NA	NA	0.61	neutral	0.09	damaging	2.52	19.61	deleterious	0.08	0.35	NA	NA	0.26	neutral	0.62	disease	0.33	neutral	3	1	deleterious	0.23	neutral	3	deleterious	0.42	neutral	NA	NA	NA	NA	NA	NA	0.22	0.8	74.33	11.77	0.51	P	0.95	NA	NA	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9208	9208	T	C	MI.6648	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	2	1	M	T	aTg/aCg	8.69	1	0	possibly_damaging	0.73	deleterious	0	NA	NA	neutral	-0.27	NA	NA	NA	NA	0.63	neutral	0.09	damaging	2.70	20.80	deleterious	0.09	0.35	NA	NA	0.38	neutral	0.53	disease	0.29	neutral	4	1	deleterious	0.14	neutral	3	deleterious	0.67	deleterious	NA	NA	NA	NA	NA	NA	0.09	0.8	74.33	11.77	0.49	P	0.99	NA	NA	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9208	9208	T	A	MI.6649	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	2	1	M	K	aTg/aAg	8.69	1	0	possibly_damaging	0.73	deleterious	0	NA	NA	neutral	-0.19	NA	NA	NA	NA	0.64	neutral	0.13	damaging	3.86	23.50	deleterious	0.08	0.35	NA	NA	0.36	neutral	0.65	disease	0.33	neutral	4	1	deleterious	0.14	neutral	3	deleterious	0.66	deleterious	NA	NA	NA	NA	NA	NA	0.13	0.8	74.33	11.77	0.6	P	0.99	NA	NA	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8839	8839	G	A	MI.665	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	313	105	A	T	Gcc/Acc	-2.19	0	0.01	probably_damaging	1	neutral	0.09	neutral	2.99	deleterious	-4.96	deleterious	-3.64	high_impact	3.62	0.58	damaging	0.5	neutral	4.19	23.80	deleterious	0.31	0.65	0.88	disease	0.84	disease	0.65	disease	0.73	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.87	deleterious	-3.6	low_impact	-0.28	medium_impact	2.01	high_impact	0.76	0.9	49.12	8.67	0.31	N	0.80	disease_causing_automatic	1	0.22	rs369202065	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	9209	9209	G	C	MI.6650	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	3	1	M	I	atG/atC	7.53	1	0	possibly_damaging	0.63	deleterious	0	NA	NA	neutral	0.69	NA	NA	NA	NA	0.55	damaging	0.11	damaging	3.29	22.80	deleterious	0.08	0.35	NA	NA	0.28	neutral	0.48	neutral	0.19	neutral	6	1	deleterious	0.19	neutral	3	deleterious	0.54	deleterious	NA	NA	NA	NA	NA	NA	0.48	0.8	74.33	11.77	0.58	P	0.94	NA	NA	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9210	9210	A	G	MI.6651	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	4	2	T	A	Acc/Gcc	7.53	1	0	benign	0	neutral	1	neutral	2.6	neutral	-0.1	neutral	-1.44	neutral_impact	-0.12	0.69	neutral	0.93	neutral	-0.83	0.04	neutral	0.27	0.45	NA	NA	0.02	neutral	0.18	neutral	0.24	neutral	5	0	neutral	1	deleterious	-6	neutral	0.03	neutral	2.05	high_impact	1.9	high_impact	-1.29	low_impact	0.31	0.8	75.1	10.48	0.53	P	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9210	9210	A	C	MI.6652	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	4	2	T	P	Acc/Ccc	7.53	1	0	benign	0.01	neutral	0.19	neutral	2.53	neutral	-2.25	deleterious	-2.73	low_impact	1.75	0.56	damaging	0.42	neutral	1.27	12.09	neutral	0.14	0.4	NA	NA	0.29	neutral	0.18	neutral	0.22	neutral	6	0.81	neutral	0.59	deleterious	-6	neutral	0.09	neutral	1.07	medium_impact	-0.17	medium_impact	0.39	medium_impact	0.44	0.8	75.1	10.48	0.61	P	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9210	9210	A	T	MI.6653	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	4	2	T	S	Acc/Tcc	7.53	1	0	benign	0	neutral	0.77	neutral	2.57	neutral	-0.26	neutral	-1.06	neutral_impact	0.72	0.69	neutral	0.87	neutral	-0.19	1.13	neutral	0.42	0.55	NA	NA	0.05	neutral	0.06	neutral	0.22	neutral	6	0.23	neutral	0.89	deleterious	-6	neutral	0.04	neutral	2.05	high_impact	0.49	medium_impact	-0.54	medium_impact	0.53	0.8	75.1	10.48	0.57	P	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9211	9211	C	G	MI.6654	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	5	2	T	S	aCc/aGc	1.75	1	0	benign	0	neutral	0.77	neutral	2.57	neutral	-0.26	neutral	-1.06	neutral_impact	0.72	0.69	neutral	0.87	neutral	0.00	2.55	deleterious	0.42	0.55	NA	NA	0.05	neutral	0.06	neutral	0.22	neutral	6	0.23	neutral	0.89	deleterious	-6	neutral	0.04	neutral	2.05	high_impact	0.49	medium_impact	-0.54	medium_impact	0.53	0.8	75.1	10.48	0.47	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9211	9211	C	A	MI.6655	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	5	2	T	N	aCc/aAc	1.75	1	0	benign	0.01	neutral	0.39	neutral	2.55	neutral	-1.35	neutral	-1.86	neutral_impact	0.65	0.69	neutral	0.83	neutral	0.37	6.37	deleterious	0.41	0.5	NA	NA	0.14	neutral	0.08	neutral	0.26	neutral	5	0.6	neutral	0.69	deleterious	-6	neutral	0.05	neutral	1.07	medium_impact	0.08	medium_impact	-0.6	medium_impact	0.44	0.8	75.1	10.48	0.53	P	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9211	9211	C	T	MI.6656	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	5	2	T	I	aCc/aTc	1.75	1	0	benign	0	neutral	0.22	neutral	2.57	neutral	-1.47	neutral	-2.45	low_impact	1.12	0.68	neutral	0.9	neutral	1.84	15.20	deleterious	0.23	0.45	NA	NA	0.22	neutral	0.11	neutral	0.21	neutral	6	0.78	neutral	0.61	deleterious	-6	neutral	0.06	neutral	2.05	high_impact	-0.12	medium_impact	-0.18	medium_impact	0.36	0.8	75.1	10.48	0.56	P	0.61	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9213	9213	C	T	MI.6657	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	7	3	H	Y	Cac/Tac	-1.49	0	0	possibly_damaging	0.65	neutral	1	neutral	2.59	neutral	-1.28	neutral	-2.48	medium_impact	1.99	0.63	neutral	0.31	neutral	3.55	23.10	deleterious	0.2	0.45	NA	NA	0.45	neutral	0.36	neutral	0.24	neutral	5	0.65	neutral	0.68	deleterious	0	NA	0.56	deleterious	-1.13	low_impact	1.9	high_impact	0.6	medium_impact	0.30	0.8	74.33	12.75	0.23	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9213	9213	C	G	MI.6658	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	7	3	H	D	Cac/Gac	-1.49	0	0	possibly_damaging	0.81	neutral	0.19	neutral	2.56	neutral	-0.25	deleterious	-3.59	medium_impact	2.48	0.63	neutral	0.36	neutral	3.70	23.30	deleterious	0.2	0.45	NA	NA	0.5	disease	0.53	disease	0.56	disease	1	0.89	neutral	0.19	neutral	0	NA	0.59	deleterious	-1.48	low_impact	-0.17	medium_impact	1.04	medium_impact	0.19	0.8	74.33	12.75	0.35	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9213	9213	C	A	MI.6659	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	7	3	H	N	Cac/Aac	-1.49	0	0	possibly_damaging	0.73	neutral	0.34	neutral	2.58	neutral	-0.23	neutral	-2.15	low_impact	1.68	0.67	neutral	0.72	neutral	2.67	20.60	deleterious	0.37	0.5	NA	NA	0.27	neutral	0.39	neutral	0.17	neutral	7	0.77	neutral	0.31	neutral	-3	neutral	0.49	deleterious	-1.29	low_impact	0.03	medium_impact	0.32	medium_impact	0.26	0.8	74.33	12.75	0.42	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8840	8840	C	T	MI.666	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	314	105	A	V	gCc/gTc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	3.02	deleterious	-4.33	deleterious	-3.75	high_impact	3.97	0.44	damaging	0.34	neutral	4.46	24.20	deleterious	0.33	0.65	0.94	disease	0.85	disease	0.64	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.3	high_impact	0.62	0.9	49.12	8.67	0.69	P	0.75	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9214	9214	A	G	MI.6660	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	8	3	H	R	cAc/cGc	7.3	1	0	possibly_damaging	0.66	neutral	0.46	neutral	2.61	neutral	-0.12	neutral	-2.41	low_impact	1.71	0.88	neutral	0.7	neutral	3.31	22.90	deleterious	0.22	0.45	NA	NA	0.41	neutral	0.38	neutral	0.18	neutral	6	0.65	neutral	0.4	neutral	-3	neutral	0.55	deleterious	-1.15	low_impact	0.15	medium_impact	0.35	medium_impact	0.23	0.8	74.33	12.75	0.55	P	0.99	polymorphism	1	0.06	.	.	.	.	.	.	COSM1155699	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9214	9214	A	C	MI.6661	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	8	3	H	P	cAc/cCc	7.3	1	0	possibly_damaging	0.88	neutral	0.19	neutral	2.56	neutral	-1.52	deleterious	-4.11	medium_impact	2.68	0.62	neutral	0.35	neutral	3.59	23.20	deleterious	0.17	0.45	NA	NA	0.59	disease	0.49	neutral	0.52	disease	0	0.93	neutral	0.16	neutral	0	NA	0.72	deleterious	-1.71	low_impact	-0.17	medium_impact	1.22	medium_impact	0.19	0.8	74.33	12.75	0.57	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9214	9214	A	T	MI.6662	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	8	3	H	L	cAc/cTc	7.3	1	0	possibly_damaging	0.66	neutral	0.73	neutral	2.68	neutral	0	deleterious	-4.22	medium_impact	2.13	0.65	neutral	0.45	neutral	4.19	23.80	deleterious	0.2	0.45	NA	NA	0.47	neutral	0.47	neutral	0.31	neutral	4	0.59	neutral	0.54	deleterious	0	NA	0.56	deleterious	-1.15	low_impact	0.44	medium_impact	0.73	medium_impact	0.17	0.8	74.33	12.75	0.53	P	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9215	9215	C	A	MI.6663	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	9	3	H	Q	caC/caA	8.69	1	0	possibly_damaging	0.77	neutral	0.37	neutral	2.57	neutral	-0.05	neutral	-2.33	low_impact	1.49	0.65	neutral	0.57	neutral	3.70	23.30	deleterious	0.24	0.45	NA	NA	0.32	neutral	0.39	neutral	0.17	neutral	7	0.79	neutral	0.3	neutral	-3	neutral	0.56	deleterious	-1.38	low_impact	0.06	medium_impact	0.15	medium_impact	0.34	0.8	74.33	12.75	0.59	P	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9215	9215	C	G	MI.6664	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	9	3	H	Q	caC/caG	8.69	1	0	possibly_damaging	0.77	neutral	0.37	neutral	2.57	neutral	-0.05	neutral	-2.33	low_impact	1.49	0.65	neutral	0.57	neutral	3.36	22.90	deleterious	0.24	0.45	NA	NA	0.32	neutral	0.39	neutral	0.17	neutral	7	0.79	neutral	0.3	neutral	-3	neutral	0.56	deleterious	-1.38	low_impact	0.06	medium_impact	0.15	medium_impact	0.34	0.8	74.33	12.75	0.58	P	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9216	9216	C	G	MI.6665	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	10	4	Q	E	Caa/Gaa	2.21	1	0	possibly_damaging	0.58	neutral	0.19	neutral	2.58	neutral	-0.29	neutral	-1.6	medium_impact	2.98	0.62	neutral	0.35	neutral	2.86	21.70	deleterious	0.38	0.5	NA	NA	0.27	neutral	0.54	disease	0.37	neutral	3	0.81	neutral	0.31	neutral	0	NA	0.51	deleterious	-1.01	low_impact	-0.17	medium_impact	1.49	medium_impact	0.51	0.8	74.71	11.99	0.53	P	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9216	9216	C	A	MI.6666	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	10	4	Q	K	Caa/Aaa	2.21	1	0	possibly_damaging	0.77	neutral	0.29	neutral	2.61	neutral	0.58	neutral	-1.99	low_impact	1.48	0.62	neutral	0.57	neutral	2.82	21.50	deleterious	0.41	0.5	NA	NA	0.18	neutral	0.25	neutral	0.22	neutral	6	0.82	neutral	0.26	neutral	-3	neutral	0.53	deleterious	-1.38	low_impact	-0.03	medium_impact	0.14	medium_impact	0.49	0.8	74.71	11.99	0.58	P	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9217	9217	A	C	MI.6667	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	11	4	Q	P	cAa/cCa	3.6	1	0	probably_damaging	0.92	neutral	0.25	neutral	2.53	neutral	-2.41	deleterious	-3.4	medium_impact	2.77	0.6	damaging	0.3	neutral	3.24	22.80	deleterious	0.14	0.4	NA	NA	0.54	disease	0.51	disease	0.55	disease	1	0.94	neutral	0.17	neutral	1	deleterious	0.71	deleterious	-1.9	low_impact	-0.08	medium_impact	1.3	medium_impact	0.28	0.8	74.71	11.99	0.46	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9217	9217	A	T	MI.6668	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	11	4	Q	L	cAa/cTa	3.6	1	0	possibly_damaging	0.77	neutral	0.72	neutral	2.52	neutral	-1.73	deleterious	-3.98	medium_impact	2.35	0.64	neutral	0.4	neutral	3.67	23.30	deleterious	0.19	0.45	NA	NA	0.39	neutral	0.43	neutral	0.19	neutral	6	0.72	neutral	0.48	deleterious	0	NA	0.61	deleterious	-1.38	low_impact	0.43	medium_impact	0.92	medium_impact	0.26	0.8	74.71	11.99	0.45	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9217	9217	A	G	MI.6669	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	11	4	Q	R	cAa/cGa	3.6	1	0	possibly_damaging	0.84	neutral	0.23	neutral	2.53	neutral	-0.64	neutral	-2.05	low_impact	1.9	0.65	neutral	0.46	neutral	3.33	22.90	deleterious	0.34	0.5	NA	NA	0.38	neutral	0.35	neutral	0.19	neutral	6	0.89	neutral	0.2	neutral	-3	neutral	0.63	deleterious	-1.57	low_impact	-0.11	medium_impact	0.52	medium_impact	0.32	0.8	74.71	11.99	0.58	P	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8840	8840	C	A	MI.667	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	314	105	A	D	gCc/gAc	6.14	1	0	probably_damaging	1	deleterious	0	neutral	2.96	deleterious	-7.05	deleterious	-5.5	high_impact	4.32	0.56	damaging	0.42	neutral	4.43	24.20	deleterious	0.1	0.65	0.96	disease	0.92	disease	0.74	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.6	high_impact	0.55	0.9	49.12	8.67	0.51	P	0.99	disease_causing	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9218	9218	A	C	MI.6670	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	12	4	Q	H	caA/caC	5.68	1	0	probably_damaging	0.95	neutral	0.81	neutral	2.5	neutral	-2.17	neutral	-2.18	medium_impact	2.17	0.62	neutral	0.58	neutral	3.36	22.90	deleterious	0.3	0.45	NA	NA	0.25	neutral	0.25	neutral	0.21	neutral	6	0.95	neutral	0.43	neutral	1	deleterious	0.68	deleterious	-2.11	low_impact	0.55	medium_impact	0.76	medium_impact	0.30	0.8	74.71	11.99	0.48	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9218	9218	A	T	MI.6671	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	12	4	Q	H	caA/caT	5.68	1	0	probably_damaging	0.95	neutral	0.81	neutral	2.5	neutral	-2.17	neutral	-2.18	medium_impact	2.17	0.62	neutral	0.58	neutral	3.52	23.10	deleterious	0.3	0.45	NA	NA	0.25	neutral	0.25	neutral	0.21	neutral	6	0.95	neutral	0.43	neutral	1	deleterious	0.68	deleterious	-2.11	low_impact	0.55	medium_impact	0.76	medium_impact	0.30	0.8	74.71	11.99	0.51	P	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9219	9219	T	C	MI.6672	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	13	5	S	P	Tca/Cca	3.37	1	0	benign	0.07	neutral	0.23	neutral	2.55	neutral	-1.64	neutral	-1.14	neutral_impact	0.55	0.56	damaging	0.29	neutral	0.97	10.47	neutral	0.3	0.45	NA	NA	0.36	neutral	0.32	neutral	0.15	neutral	7	0.75	neutral	0.58	deleterious	-6	neutral	0.13	neutral	0.22	medium_impact	-0.11	medium_impact	-0.69	medium_impact	0.19	0.8	23.75	21.19	0.55	P	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9219	9219	T	G	MI.6673	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	13	5	S	A	Tca/Gca	3.37	1	0	benign	0	neutral	0.53	neutral	2.58	neutral	-0.08	neutral	-0.85	neutral_impact	-1.08	0.68	neutral	0.86	neutral	-1.04	0.01	neutral	0.5	0.6	NA	NA	0.03	neutral	0.29	neutral	0.17	neutral	7	0.47	neutral	0.77	deleterious	-6	neutral	0.04	neutral	2.05	high_impact	0.22	medium_impact	-2.15	low_impact	0.34	0.8	23.75	21.19	0.49	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9219	9219	T	A	MI.6674	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	13	5	S	T	Tca/Aca	3.37	1	0	benign	0	neutral	0.41	neutral	2.57	neutral	-0.39	neutral	0.17	neutral_impact	-0.85	0.77	neutral	0.97	neutral	-0.37	0.47	neutral	0.47	0.55	NA	NA	0.06	neutral	0.15	neutral	0.19	neutral	6	0.59	neutral	0.71	deleterious	-6	neutral	0.05	neutral	2.05	high_impact	0.1	medium_impact	-1.94	low_impact	0.48	0.8	23.75	21.19	0.55	P	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9220	9220	C	G	MI.6675	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	14	5	S	W	tCa/tGa	1.29	0.98	0	benign	0.32	neutral	0.18	neutral	2.5	deleterious	-4.38	neutral	-2.47	low_impact	0.9	0.63	neutral	0.38	neutral	2.78	21.20	deleterious	0.16	0.45	NA	NA	0.34	neutral	0.46	neutral	0.16	neutral	7	0.79	neutral	0.43	neutral	-6	neutral	0.42	neutral	-0.55	medium_impact	-0.18	medium_impact	-0.38	medium_impact	0.10	0.8	23.75	21.19	0.5	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9220	9220	C	T	MI.6676	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	14	5	S	L	tCa/tTa	1.29	0.98	0	benign	0	neutral	0.66	neutral	2.6	neutral	-0.96	neutral	-1.54	neutral_impact	-0.3	0.75	neutral	0.78	neutral	0.93	10.25	neutral	0.36	0.5	NA	NA	0.15	neutral	0.33	neutral	0.2	neutral	6	0.34	neutral	0.83	deleterious	-6	neutral	0.06	neutral	2.05	high_impact	0.36	medium_impact	-1.45	low_impact	0.50	0.8	23.75	21.19	0.42	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9222	9222	C	G	MI.6677	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	16	6	H	D	Cat/Gat	-5.19	0	0	probably_damaging	1	neutral	0.18	neutral	2.17	neutral	-1.08	deleterious	-6.46	medium_impact	2.87	0.6	neutral	0.03	damaging	3.88	23.50	deleterious	0.17	0.45	NA	NA	0.58	disease	0.78	disease	0.74	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	-0.18	medium_impact	1.39	medium_impact	0.28	0.8	73.56	11.82	0.3	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9222	9222	C	T	MI.6678	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	16	6	H	Y	Cat/Tat	-5.19	0	0	probably_damaging	0.99	neutral	0.92	neutral	2.19	neutral	-2.87	deleterious	-4.48	medium_impact	2.95	0.54	damaging	0.03	damaging	3.77	23.40	deleterious	0.23	0.45	NA	NA	0.56	disease	0.73	disease	0.7	disease	4	0.99	deleterious	0.47	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	0.8	medium_impact	1.46	medium_impact	0.21	0.8	73.56	11.82	0.21	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9222	9222	C	A	MI.6679	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	16	6	H	N	Cat/Aat	-5.19	0	0	probably_damaging	0.99	neutral	0.45	neutral	2.17	neutral	-1.2	deleterious	-4.66	low_impact	1.87	0.49	damaging	0.06	damaging	4.02	23.60	deleterious	0.43	0.55	NA	NA	0.45	neutral	0.73	disease	0.53	disease	1	0.99	deleterious	0.23	neutral	-2	neutral	0.76	deleterious	-2.81	low_impact	0.14	medium_impact	0.49	medium_impact	0.25	0.8	73.56	11.82	0.28	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8840	8840	C	G	MI.668	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	314	105	A	G	gCc/gGc	6.14	1	0	probably_damaging	0.99	neutral	0.14	neutral	3.1	deleterious	-3.14	deleterious	-3.68	medium_impact	2.25	0.54	damaging	0.48	neutral	3.89	23.50	deleterious	0.22	0.65	0.7	disease	0.74	disease	0.48	neutral	0.43	neutral	1	1	deleterious	0.08	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	-0.15	medium_impact	0.83	medium_impact	0.74	0.9	49.12	8.67	0.53	P	0.86	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9223	9223	A	C	MI.6680	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	17	6	H	P	cAt/cCt	4.52	1	0	probably_damaging	1	neutral	0.35	neutral	2.14	neutral	-2.34	deleterious	-6.38	medium_impact	2.64	0.59	damaging	0.04	damaging	3.16	22.60	deleterious	0.14	0.4	NA	NA	0.6	disease	0.75	disease	0.74	disease	5	1	deleterious	0.18	neutral	1	deleterious	0.82	deleterious	-3.78	low_impact	0.04	medium_impact	1.18	medium_impact	0.18	0.8	73.56	11.82	0.4	N	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9223	9223	A	T	MI.6681	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	17	6	H	L	cAt/cTt	4.52	1	0	probably_damaging	1	neutral	0.61	neutral	2.22	neutral	-1.68	deleterious	-7.99	medium_impact	3.15	0.57	damaging	0.04	damaging	3.68	23.30	deleterious	0.18	0.45	NA	NA	0.57	disease	0.77	disease	0.74	disease	5	1	deleterious	0.31	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	0.3	medium_impact	1.64	medium_impact	0.15	0.8	73.56	11.82	0.47	N	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9223	9223	A	G	MI.6682	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	17	6	H	R	cAt/cGt	4.52	1	0	probably_damaging	1	neutral	0.33	neutral	2.18	neutral	-1.24	deleterious	-5.74	medium_impact	3.15	0.66	neutral	0.06	damaging	2.81	21.40	deleterious	0.24	0.45	NA	NA	0.55	disease	0.73	disease	0.72	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	0.02	medium_impact	1.64	medium_impact	0.20	0.8	73.56	11.82	0.47	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9224	9224	T	A	MI.6683	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	18	6	H	Q	caT/caA	8.69	1	0	probably_damaging	1	neutral	0.26	neutral	2.18	neutral	-0.96	deleterious	-5.45	low_impact	1.72	0.57	damaging	0.04	damaging	3.78	23.40	deleterious	0.33	0.5	NA	NA	0.49	neutral	0.73	disease	0.54	disease	1	1	deleterious	0.13	neutral	-2	neutral	0.78	deleterious	-3.78	low_impact	-0.07	medium_impact	0.36	medium_impact	0.30	0.8	73.56	11.82	0.5	P	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9224	9224	T	G	MI.6684	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	18	6	H	Q	caT/caG	8.69	1	0	probably_damaging	1	neutral	0.26	neutral	2.18	neutral	-0.96	deleterious	-5.45	low_impact	1.72	0.57	damaging	0.04	damaging	3.57	23.20	deleterious	0.33	0.5	NA	NA	0.49	neutral	0.73	disease	0.54	disease	1	1	deleterious	0.13	neutral	-2	neutral	0.78	deleterious	-3.78	low_impact	-0.07	medium_impact	0.36	medium_impact	0.30	0.8	73.56	11.82	0.49	P	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9225	9225	G	A	MI.6685	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	19	7	A	T	Gcc/Acc	-2.19	0	0	possibly_damaging	0.47	neutral	0.35	neutral	2.29	neutral	-0.47	neutral	-0.21	neutral_impact	0.38	0.7	neutral	0.56	neutral	2.81	21.40	deleterious	0.43	0.55	NA	NA	0.31	neutral	0.32	neutral	0.17	neutral	7	0.62	neutral	0.44	neutral	-3	neutral	0.46	deleterious	-0.82	medium_impact	0.04	medium_impact	-0.84	medium_impact	0.64	0.8	55.56	9.3	0.41	N	0.86	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9225	9225	G	T	MI.6686	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	19	7	A	S	Gcc/Tcc	-2.19	0	0	benign	0.34	neutral	0.38	neutral	2.37	neutral	0.52	neutral	-0.1	neutral_impact	-0.42	0.68	neutral	0.94	neutral	2.01	16.30	deleterious	0.52	0.6	NA	NA	0.21	neutral	0.18	neutral	0.19	neutral	6	0.55	neutral	0.52	deleterious	-6	neutral	0.29	neutral	-0.59	medium_impact	0.07	medium_impact	-1.56	low_impact	0.31	0.8	55.56	9.3	0.52	N	0.89	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9225	9225	G	C	MI.6687	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	19	7	A	P	Gcc/Ccc	-2.19	0	0	benign	0.03	neutral	0.26	neutral	2.43	neutral	1.01	neutral	4.49	neutral_impact	-2.04	0.64	neutral	0.35	neutral	-0.39	0.40	neutral	0.36	0.5	NA	NA	0.05	neutral	0.16	neutral	0.2	neutral	6	0.72	neutral	0.62	deleterious	-6	neutral	0.14	neutral	0.6	medium_impact	-0.07	medium_impact	-3.01	low_impact	0.37	0.8	55.56	9.3	0.48	N	0.99	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9226	9226	C	A	MI.6688	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	20	7	A	D	gCc/gAc	2.21	0.99	0	probably_damaging	0.96	neutral	0.17	neutral	2.29	neutral	-0.54	neutral	-0.62	neutral_impact	-0.32	0.62	neutral	0.02	damaging	4.52	24.30	deleterious	0.35	0.5	NA	NA	0.43	neutral	0.31	neutral	0.2	neutral	6	0.98	neutral	0.11	neutral	-2	neutral	0.71	deleterious	-2.21	low_impact	-0.2	medium_impact	-1.47	low_impact	0.22	0.8	55.56	9.3	0.43	N	0.99	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9226	9226	C	G	MI.6689	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	20	7	A	G	gCc/gGc	2.21	0.99	0	benign	0.21	neutral	0.29	neutral	2.26	neutral	-1.09	neutral	-1.16	neutral_impact	-0.26	0.72	neutral	0.29	neutral	2.32	18.27	deleterious	0.51	0.6	NA	NA	0.29	neutral	0.45	neutral	0.17	neutral	7	0.65	neutral	0.54	deleterious	-6	neutral	0.25	neutral	-0.31	medium_impact	-0.03	medium_impact	-1.42	low_impact	0.50	0.8	55.56	9.3	0.45	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8842	8842	A	C	MI.669	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	316	106	I	L	Atc/Ctc	-11.44	0	0.02	benign	0.06	neutral	1	neutral	4.54	neutral	0.8	neutral	-1.59	neutral_impact	-0.54	0.92	neutral	0.58	neutral	0.69	8.77	deleterious	0.35	0.65	0.29	neutral	0.3	neutral	0.26	neutral	0.45	neutral	1	0.06	neutral	0.97	deleterious	-6	neutral	0.14	neutral	0.38	medium_impact	1.98	high_impact	-1.56	low_impact	0.59	0.9	42.48	7.64	0.29	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9226	9226	C	T	MI.6690	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	20	7	A	V	gCc/gTc	2.21	0.99	0	possibly_damaging	0.5	neutral	0.42	neutral	2.26	neutral	-1.06	neutral	-1.15	low_impact	0.9	0.59	damaging	0.09	damaging	4.27	24.00	deleterious	0.42	0.5	NA	NA	0.38	neutral	0.51	disease	0.25	neutral	5	0.56	neutral	0.46	neutral	-3	neutral	0.57	deleterious	-0.87	medium_impact	0.11	medium_impact	-0.38	medium_impact	0.64	0.8	55.56	9.3	0.42	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9228	9228	T	G	MI.6691	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	22	8	Y	D	Tat/Gat	-5.42	0	0	probably_damaging	1	neutral	0.16	neutral	2	deleterious	-6.38	deleterious	-6.57	high_impact	3.64	0.6	damaging	0.05	damaging	3.81	23.40	deleterious	0.03	0.35	NA	NA	0.65	disease	0.81	disease	0.75	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	-0.22	medium_impact	2.08	high_impact	0.10	0.8	78.16	10.8	0.31	N	0.99	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9228	9228	T	C	MI.6692	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	22	8	Y	H	Tat/Cat	-5.42	0	0	probably_damaging	1	neutral	0.64	neutral	2.02	deleterious	-4.74	deleterious	-3.47	medium_impact	2.84	0.64	neutral	0.07	damaging	3.39	23.00	deleterious	0.09	0.35	NA	NA	0.47	neutral	0.81	disease	0.71	disease	4	1	deleterious	0.32	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.33	medium_impact	1.36	medium_impact	0.09	0.8	78.16	10.8	0.26	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9228	9228	T	A	MI.6693	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	22	8	Y	N	Tat/Aat	-5.42	0	0	probably_damaging	1	neutral	0.29	neutral	2.01	deleterious	-5.59	deleterious	-6.1	medium_impact	2.94	0.65	neutral	0.07	damaging	3.86	23.50	deleterious	0.05	0.35	NA	NA	0.55	disease	0.75	disease	0.74	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	-0.03	medium_impact	1.45	medium_impact	0.10	0.8	78.16	10.8	0.27	N	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9229	9229	A	T	MI.6694	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	23	8	Y	F	tAt/tTt	5.91	1	0	probably_damaging	0.98	neutral	0.6	neutral	2.44	neutral	-2	neutral	-0.8	neutral_impact	-0.21	0.69	neutral	0.48	neutral	1.47	13.17	neutral	0.19	0.45	NA	NA	0.05	neutral	0.31	neutral	0.15	neutral	7	0.98	deleterious	0.31	neutral	-2	neutral	0.71	deleterious	-2.51	low_impact	0.29	medium_impact	-1.37	low_impact	0.20	0.8	78.16	10.8	0.57	P	0.72	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9229	9229	A	G	MI.6695	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	23	8	Y	C	tAt/tGt	5.91	1	0	probably_damaging	1	neutral	0.14	neutral	2	deleterious	-6.64	deleterious	-5.89	high_impact	3.64	0.58	damaging	0.04	damaging	3.37	22.90	deleterious	0.04	0.35	NA	NA	0.61	disease	0.79	disease	0.75	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	-0.26	medium_impact	2.08	high_impact	0.12	0.8	78.16	10.8	0.53	P	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9229	9229	A	C	MI.6696	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	23	8	Y	S	tAt/tCt	5.91	1	0	probably_damaging	1	neutral	0.37	neutral	2.03	deleterious	-5.01	deleterious	-5.81	medium_impact	3.09	0.65	neutral	0.09	damaging	3.58	23.20	deleterious	0.05	0.35	NA	NA	0.53	disease	0.75	disease	0.74	disease	5	1	deleterious	0.19	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.06	medium_impact	1.59	medium_impact	0.15	0.8	78.16	10.8	0.51	N	0.96	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9231	9231	C	G	MI.6697	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	25	9	H	D	Cat/Gat	-6.12	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.92	deleterious	-4.23	deleterious	-7.59	high_impact	3.96	0.6	neutral	0.02	damaging	3.64	23.20	deleterious	0.12	0.4	NA	NA	0.68	disease	0.84	disease	0.78	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-2.81	low_impact	-0.15	medium_impact	2.37	high_impact	0.19	0.8	75.1	11.39	0.36	N	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9231	9231	C	A	MI.6698	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	25	9	H	N	Cat/Aat	-6.12	0	0	probably_damaging	0.99	neutral	0.3	neutral	1.92	deleterious	-3.8	deleterious	-5.9	high_impact	3.5	0.6	neutral	0.02	damaging	3.90	23.50	deleterious	0.34	0.5	NA	NA	0.63	disease	0.79	disease	0.75	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-2.81	low_impact	-0.02	medium_impact	1.95	medium_impact	0.13	0.8	75.1	11.39	0.31	N	0.96	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9231	9231	C	T	MI.6699	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	25	9	H	Y	Cat/Tat	-6.12	0	0	probably_damaging	0.98	neutral	1	neutral	2.05	neutral	-0.05	deleterious	-5.03	medium_impact	2.29	0.6	damaging	0.02	damaging	3.51	23.10	deleterious	0.35	0.5	NA	NA	0.68	disease	0.74	disease	0.71	disease	4	0.98	deleterious	0.51	deleterious	1	deleterious	0.80	deleterious	-2.51	low_impact	1.9	high_impact	0.87	medium_impact	0.07	0.8	75.1	11.39	0.18	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	COSM6716199	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8555	8555	T	A	MI.67	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	29	10	I	N	aTt/aAt	-3.11	0	0	benign	0.01	neutral	0.15	neutral	4.71	neutral	-0.52	neutral	-1.57	low_impact	0.88	0.85	neutral	0.68	neutral	2.70	20.80	deleterious	0.32	0.65	0.38	neutral	0.65	disease	0.36	neutral	0.52	disease	0	0.85	neutral	0.57	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	-0.13	medium_impact	-0.34	medium_impact	0.45	0.9	27.43	16.7	0.39	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8842	8842	A	T	MI.670	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	316	106	I	F	Atc/Ttc	-11.44	0	0.02	possibly_damaging	0.56	neutral	0.41	neutral	4.38	neutral	-0.65	deleterious	-3.03	neutral_impact	-0.04	0.8	neutral	0.7	neutral	2.25	17.87	deleterious	0.44	0.65	0.29	neutral	0.51	disease	0.29	neutral	0.36	neutral	3	0.61	neutral	0.43	neutral	-3	neutral	0.52	deleterious	-0.86	medium_impact	0.2	medium_impact	-1.13	low_impact	0.61	0.9	42.48	7.64	0.3	N	0.97	polymorphism	0.99	0.07	rs386829052	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9232	9232	A	G	MI.6700	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	26	9	H	R	cAt/cGt	5.68	1	0	probably_damaging	0.98	neutral	0.34	neutral	1.94	deleterious	-3.77	deleterious	-6.74	high_impact	3.96	0.69	neutral	0.03	damaging	2.82	21.50	deleterious	0.21	0.45	NA	NA	0.68	disease	0.78	disease	0.74	disease	5	0.99	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-2.51	low_impact	0.03	medium_impact	2.37	high_impact	0.13	0.8	75.1	11.39	0.57	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9232	9232	A	T	MI.6701	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	26	9	H	L	cAt/cTt	5.68	1	0	probably_damaging	0.98	neutral	0.66	neutral	1.95	neutral	-2.47	deleterious	-9.26	high_impact	4.31	0.58	damaging	0.02	damaging	3.60	23.20	deleterious	0.08	0.35	NA	NA	0.7	disease	0.79	disease	0.77	disease	5	0.98	deleterious	0.34	neutral	2	deleterious	0.80	deleterious	-2.51	low_impact	0.36	medium_impact	2.68	high_impact	0.04	0.8	75.1	11.39	0.57	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9232	9232	A	C	MI.6702	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	26	9	H	P	cAt/cCt	5.68	1	0	probably_damaging	1	neutral	0.21	neutral	1.9	deleterious	-4.82	deleterious	-8.43	high_impact	3.96	0.57	damaging	0.03	damaging	3.05	22.40	deleterious	0.08	0.35	NA	NA	0.7	disease	0.79	disease	0.75	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.14	medium_impact	2.37	high_impact	0.06	0.8	75.1	11.39	0.56	P	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9233	9233	T	A	MI.6703	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	27	9	H	Q	caT/caA	8.69	1	0	probably_damaging	0.99	neutral	0.29	neutral	1.93	deleterious	-3.41	deleterious	-6.74	medium_impact	2.87	0.64	neutral	0.03	damaging	3.48	23.10	deleterious	0.3	0.45	NA	NA	0.65	disease	0.78	disease	0.73	disease	5	0.99	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-2.81	low_impact	-0.03	medium_impact	1.39	medium_impact	0.21	0.8	75.1	11.39	0.53	P	0.94	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9233	9233	T	G	MI.6704	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	27	9	H	Q	caT/caG	8.69	1	0	probably_damaging	0.99	neutral	0.29	neutral	1.93	deleterious	-3.41	deleterious	-6.74	medium_impact	2.87	0.64	neutral	0.03	damaging	3.38	22.90	deleterious	0.3	0.45	NA	NA	0.65	disease	0.78	disease	0.73	disease	5	0.99	deleterious	0.15	neutral	1	deleterious	0.80	deleterious	-2.81	low_impact	-0.03	medium_impact	1.39	medium_impact	0.21	0.8	75.1	11.39	0.51	P	0.94	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9234	9234	A	G	MI.6705	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	28	10	M	V	Ata/Gta	-1.26	0	0	possibly_damaging	0.54	neutral	0.51	neutral	2.37	neutral	0.43	neutral	-1.95	neutral_impact	0.36	0.65	neutral	0.47	neutral	2.35	18.47	deleterious	0.43	0.55	NA	NA	0.58	disease	0.47	neutral	0.51	disease	0	0.52	neutral	0.49	deleterious	-3	neutral	0.47	deleterious	-0.94	medium_impact	0.2	medium_impact	-0.86	medium_impact	0.17	0.8	73.18	11.92	0.27	N	0.96	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9234	9234	A	T	MI.6706	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	28	10	M	L	Ata/Tta	-1.26	0	0	benign	0.42	neutral	0.66	neutral	2.75	neutral	2.09	neutral	-0.38	neutral_impact	-0.86	0.64	neutral	0.77	neutral	1.16	11.56	neutral	0.35	0.5	NA	NA	0.14	neutral	0.22	neutral	0.23	neutral	5	0.34	neutral	0.62	deleterious	-6	neutral	0.30	neutral	-0.73	medium_impact	0.36	medium_impact	-1.95	low_impact	0.21	0.8	73.18	11.92	0.39	N	0.95	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9234	9234	A	C	MI.6707	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	28	10	M	L	Ata/Cta	-1.26	0	0	benign	0.42	neutral	0.66	neutral	2.75	neutral	2.09	neutral	-0.38	neutral_impact	-0.86	0.64	neutral	0.77	neutral	1.06	11.02	neutral	0.35	0.5	NA	NA	0.14	neutral	0.22	neutral	0.23	neutral	5	0.34	neutral	0.62	deleterious	-6	neutral	0.30	neutral	-0.73	medium_impact	0.36	medium_impact	-1.95	low_impact	0.21	0.8	73.18	11.92	0.39	N	0.95	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9235	9235	T	A	MI.6708	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	29	10	M	K	aTa/aAa	8.92	1	0	possibly_damaging	0.74	neutral	0.29	neutral	2.18	neutral	-2.96	deleterious	-4.24	medium_impact	2.51	0.61	neutral	0.4	neutral	3.74	23.30	deleterious	0.08	0.35	NA	NA	0.71	disease	0.68	disease	0.73	disease	5	0.8	neutral	0.28	neutral	0	NA	0.67	deleterious	-1.31	low_impact	-0.03	medium_impact	1.07	medium_impact	0.10	0.8	73.18	11.92	0.61	P	0.99	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9235	9235	T	C	MI.6709	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	29	10	M	T	aTa/aCa	8.92	1	0	possibly_damaging	0.86	neutral	0.39	neutral	2.21	neutral	-1.88	deleterious	-3.75	medium_impact	2.51	0.61	neutral	0.55	neutral	2.80	21.40	deleterious	0.17	0.45	NA	NA	0.69	disease	0.61	disease	0.72	disease	4	0.86	neutral	0.27	neutral	0	NA	0.70	deleterious	-1.64	low_impact	0.08	medium_impact	1.07	medium_impact	0.05	0.8	73.18	11.92	0.52	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8842	8842	A	G	MI.671	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	316	106	I	V	Atc/Gtc	-11.44	0	0.02	benign	0.01	neutral	0.44	neutral	4.35	neutral	0.47	neutral	-0.46	neutral_impact	-0.59	0.91	neutral	0.88	neutral	-1.30	0.01	neutral	0.52	0.65	0.3	neutral	0.1	neutral	0.24	neutral	0.24	neutral	5	0.55	neutral	0.72	deleterious	-6	neutral	0.09	neutral	1.14	medium_impact	0.23	medium_impact	-1.6	low_impact	0.36	0.9	42.48	7.64	0.48	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9236	9236	A	C	MI.6710	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	30	10	M	I	atA/atC	5.68	1	0	possibly_damaging	0.63	neutral	0.39	neutral	2.42	neutral	0.72	neutral	-1.5	neutral_impact	-0.02	0.62	neutral	0.71	neutral	3.17	22.70	deleterious	0.35	0.5	NA	NA	0.46	neutral	0.27	neutral	0.26	neutral	5	0.67	neutral	0.38	neutral	-3	neutral	0.50	deleterious	-1.09	low_impact	0.08	medium_impact	-1.2	low_impact	0.21	0.8	73.18	11.92	0.59	P	0.95	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9236	9236	A	T	MI.6711	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	30	10	M	I	atA/atT	5.68	1	0	possibly_damaging	0.63	neutral	0.39	neutral	2.42	neutral	0.72	neutral	-1.5	neutral_impact	-0.02	0.62	neutral	0.71	neutral	3.33	22.90	deleterious	0.35	0.5	NA	NA	0.46	neutral	0.27	neutral	0.26	neutral	5	0.67	neutral	0.38	neutral	-3	neutral	0.50	deleterious	-1.09	low_impact	0.08	medium_impact	-1.2	low_impact	0.21	0.8	73.18	11.92	0.6	P	0.95	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9237	9237	G	A	MI.6712	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	31	11	V	M	Gta/Ata	7.07	1	0	possibly_damaging	0.55	neutral	0.23	neutral	1.86	deleterious	-3.65	deleterious	-2.57	medium_impact	3.38	0.64	neutral	0.02	damaging	3.44	23.00	deleterious	0.25	0.45	NA	NA	0.56	disease	0.67	disease	0.66	disease	3	0.76	neutral	0.34	neutral	0	NA	0.57	deleterious	-0.95	medium_impact	-0.11	medium_impact	1.85	medium_impact	0.81	0.85	74.33	12.08	0.54	P	0.96	polymorphism	1	0.12	rs1057516064	Likely_pathogenic	Mitochondrial_encephalopathy|Seizure_Disorders|Developmental_delay	354305	Human_Phenotype_Ontology:HP:0006789,MedGen:C1852373|MedGen:C0014544,Orphanet:ORPHA166463|MedGen:C0424605	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	9237	9237	G	T	MI.6713	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	31	11	V	L	Gta/Tta	7.07	1	0	benign	0	neutral	0.74	neutral	2.01	neutral	-1.56	deleterious	-2.56	low_impact	1.74	0.6	damaging	0.02	damaging	1.55	13.56	neutral	0.22	0.45	NA	NA	0.41	neutral	0.49	neutral	0.17	neutral	7	0.25	neutral	0.87	deleterious	-6	neutral	0.19	neutral	2.05	high_impact	0.45	medium_impact	0.38	medium_impact	0.51	0.8	74.33	12.08	0.45	N	0.68	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9237	9237	G	C	MI.6714	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	31	11	V	L	Gta/Cta	7.07	1	0	benign	0	neutral	0.74	neutral	2.01	neutral	-1.56	deleterious	-2.56	low_impact	1.74	0.6	damaging	0.02	damaging	1.39	12.75	neutral	0.22	0.45	NA	NA	0.41	neutral	0.49	neutral	0.17	neutral	7	0.25	neutral	0.87	deleterious	-6	neutral	0.19	neutral	2.05	high_impact	0.45	medium_impact	0.38	medium_impact	0.51	0.8	74.33	12.08	0.45	N	0.68	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9238	9238	T	G	MI.6715	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	32	11	V	G	gTa/gGa	9.15	1	0	probably_damaging	0.96	neutral	0.32	neutral	1.85	deleterious	-4.23	deleterious	-6	high_impact	4.19	0.6	neutral	0.07	damaging	3.59	23.20	deleterious	0.05	0.35	NA	NA	0.61	disease	0.69	disease	0.68	disease	4	0.97	neutral	0.18	neutral	2	deleterious	0.74	deleterious	-2.21	low_impact	0.01	medium_impact	2.57	high_impact	0.12	0.8	74.33	12.08	0.53	P	0.88	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9238	9238	T	C	MI.6716	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	32	11	V	A	gTa/gCa	9.15	1	0	benign	0.3	neutral	0.49	neutral	1.91	neutral	-2.67	deleterious	-3.42	medium_impact	3.38	0.6	neutral	0.13	damaging	3.22	22.70	deleterious	0.22	0.45	NA	NA	0.45	neutral	0.56	disease	0.41	neutral	2	0.42	neutral	0.6	deleterious	-3	neutral	0.41	neutral	-0.51	medium_impact	0.18	medium_impact	1.85	medium_impact	0.18	0.8	74.33	12.08	0.56	P	0.39	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9238	9238	T	A	MI.6717	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	32	11	V	E	gTa/gAa	9.15	1	0	probably_damaging	0.92	neutral	0.27	neutral	1.85	deleterious	-3.87	deleterious	-5.14	high_impact	4.19	0.68	neutral	0.03	damaging	4.51	24.30	deleterious	0.05	0.35	NA	NA	0.74	disease	0.77	disease	0.75	disease	5	0.94	neutral	0.18	neutral	2	deleterious	0.68	deleterious	-1.9	low_impact	-0.06	medium_impact	2.57	high_impact	0.13	0.8	74.33	12.08	0.62	P	0.96	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9240	9240	A	C	MI.6718	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	34	12	K	Q	Aaa/Caa	-7.04	0	0	probably_damaging	0.99	neutral	0.51	neutral	2.56	neutral	-0.5	neutral	0.54	neutral_impact	-0.3	0.63	neutral	0.3	neutral	3.16	22.60	deleterious	0.43	0.55	NA	NA	0.31	neutral	0.39	neutral	0.15	neutral	7	0.99	deleterious	0.26	neutral	-2	neutral	0.71	deleterious	-2.81	low_impact	0.2	medium_impact	-1.45	low_impact	0.17	0.8	17.62	42.49	0.3	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9240	9240	A	G	MI.6719	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	34	12	K	E	Aaa/Gaa	-7.04	0	0	probably_damaging	0.98	neutral	0.62	neutral	2.67	neutral	0.91	neutral	1.88	neutral_impact	-2.01	0.73	neutral	0.47	neutral	2.36	18.58	deleterious	0.23	0.45	NA	NA	0.36	neutral	0.16	neutral	0.17	neutral	7	0.98	neutral	0.32	neutral	-2	neutral	0.72	deleterious	-2.51	low_impact	0.31	medium_impact	-2.98	low_impact	0.41	0.8	17.62	42.49	0.32	N	0.56	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8843	8843	T	C	MI.672	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	317	106	I	T	aTc/aCc	0.36	0.03	0.01	benign	0.28	deleterious	0.04	neutral	4.23	neutral	-1.76	deleterious	-3.71	low_impact	1.8	0.96	neutral	0.66	neutral	0.51	7.48	deleterious	0.47	0.65	0.58	disease	0.49	neutral	0.38	neutral	0.47	neutral	1	0.95	neutral	0.38	neutral	-2	neutral	0.42	neutral	-0.37	medium_impact	-0.49	medium_impact	0.45	medium_impact	0.52	0.9	42.48	7.64	0.42	N	0.99	polymorphism	1	0.08	rs386829053	.	.	.	.	.	COSM488776	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9241	9241	A	C	MI.6720	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	35	12	K	T	aAa/aCa	4.76	1	0	probably_damaging	0.99	neutral	0.58	neutral	2.57	neutral	-0.21	neutral	-0.34	neutral_impact	-0.48	0.67	neutral	0.42	neutral	1.43	12.94	neutral	0.19	0.45	NA	NA	0.31	neutral	0.15	neutral	0.17	neutral	7	0.99	deleterious	0.3	neutral	-2	neutral	0.71	deleterious	-2.81	low_impact	0.27	medium_impact	-1.61	low_impact	0.10	0.8	17.62	42.49	0.47	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9241	9241	A	T	MI.6721	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	35	12	K	M	aAa/aTa	4.76	1	0	probably_damaging	1	neutral	0.27	neutral	2.5	deleterious	-3.43	neutral	-1.85	low_impact	0.85	0.59	damaging	0.24	damaging	3.57	23.10	deleterious	0.12	0.4	NA	NA	0.3	neutral	0.4	neutral	0.15	neutral	7	1	deleterious	0.14	neutral	-2	neutral	0.71	deleterious	-3.78	low_impact	-0.06	medium_impact	-0.42	medium_impact	0.09	0.8	17.62	42.49	0.52	P	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9242	9242	A	T	MI.6722	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	36	12	K	N	aaA/aaT	8.69	1	0.02	probably_damaging	0.99	neutral	0.52	neutral	2.62	neutral	0.41	neutral	1.89	neutral_impact	-1.3	0.76	neutral	0.95	neutral	1.64	14.06	neutral	0.55	0.6	NA	NA	0.23	neutral	0.14	neutral	0.17	neutral	7	0.99	deleterious	0.27	neutral	-2	neutral	0.71	deleterious	-2.81	low_impact	0.21	medium_impact	-2.35	low_impact	0.21	0.8	17.62	42.49	0.56	P	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9242	9242	A	C	MI.6723	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	36	12	K	N	aaA/aaC	8.69	1	0.02	probably_damaging	0.99	neutral	0.52	neutral	2.62	neutral	0.41	neutral	1.89	neutral_impact	-1.3	0.76	neutral	0.95	neutral	1.56	13.66	neutral	0.55	0.6	NA	NA	0.23	neutral	0.14	neutral	0.17	neutral	7	0.99	deleterious	0.27	neutral	-2	neutral	0.71	deleterious	-2.81	low_impact	0.21	medium_impact	-2.35	low_impact	0.21	0.8	17.62	42.49	0.56	P	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9243	9243	C	G	MI.6724	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	37	13	P	A	Ccc/Gcc	-0.33	0.41	0	benign	0.06	neutral	0.44	neutral	2.53	neutral	-1.03	deleterious	-2.55	low_impact	1.73	0.55	damaging	0.09	damaging	1.06	11.02	neutral	0.28	0.45	NA	NA	0.38	neutral	0.39	neutral	0.19	neutral	6	0.51	neutral	0.69	deleterious	-6	neutral	0.23	neutral	0.29	medium_impact	0.13	medium_impact	0.37	medium_impact	0.53	0.8	75.1	11.56	0.3	N	0.70	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9243	9243	C	A	MI.6725	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	37	13	P	T	Ccc/Acc	-0.33	0.41	0	benign	0.33	neutral	0.34	neutral	2.5	neutral	-1.35	deleterious	-2.56	medium_impact	2.23	0.56	damaging	0.05	damaging	3.43	23.00	deleterious	0.24	0.45	NA	NA	0.57	disease	0.38	neutral	0.52	disease	0	0.59	neutral	0.51	deleterious	-3	neutral	0.39	neutral	-0.57	medium_impact	0.03	medium_impact	0.82	medium_impact	0.43	0.8	75.1	11.56	0.25	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9243	9243	C	T	MI.6726	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	37	13	P	S	Ccc/Tcc	-0.33	0.41	0	benign	0.02	neutral	0.48	neutral	2.5	neutral	-0.83	neutral	-2.34	medium_impact	2.17	0.54	damaging	0.05	damaging	1.76	14.76	neutral	0.27	0.45	NA	NA	0.54	disease	0.41	neutral	0.5	neutral	0	0.49	neutral	0.73	deleterious	-3	neutral	0.18	neutral	0.77	medium_impact	0.17	medium_impact	0.76	medium_impact	0.15	0.8	75.1	11.56	0.27	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9244	9244	C	G	MI.6727	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	38	13	P	R	cCc/cGc	7.3	1	0	possibly_damaging	0.87	neutral	0.35	neutral	2.49	neutral	-1.4	deleterious	-2.7	medium_impact	2.58	0.49	damaging	0.04	damaging	3.31	22.90	deleterious	0.12	0.4	NA	NA	0.71	disease	0.43	neutral	0.54	disease	1	0.88	neutral	0.24	neutral	0	NA	0.71	deleterious	-1.67	low_impact	0.04	medium_impact	1.13	medium_impact	0.34	0.8	75.1	11.56	0.5	P	0.93	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9244	9244	C	A	MI.6728	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	38	13	P	H	cCc/cAc	7.3	1	0	probably_damaging	0.92	neutral	0.49	neutral	2.46	neutral	-2.56	neutral	-2.48	medium_impact	3.07	0.56	damaging	0.03	damaging	3.89	23.50	deleterious	0.16	0.45	NA	NA	0.64	disease	0.48	neutral	0.52	disease	0	0.91	neutral	0.29	neutral	1	deleterious	0.73	deleterious	-1.9	low_impact	0.18	medium_impact	1.57	medium_impact	0.21	0.8	75.1	11.56	0.46	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9244	9244	C	T	MI.6729	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	38	13	P	L	cCc/cTc	7.3	1	0	possibly_damaging	0.75	neutral	0.57	neutral	2.57	neutral	-1.99	deleterious	-3.13	low_impact	1.59	0.49	damaging	0.03	damaging	4.02	23.60	deleterious	0.15	0.4	NA	NA	0.59	disease	0.4	neutral	0.45	neutral	1	0.71	neutral	0.41	neutral	-3	neutral	0.63	deleterious	-1.33	low_impact	0.26	medium_impact	0.24	medium_impact	0.57	0.8	75.1	11.56	0.5	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8843	8843	T	A	MI.673	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	317	106	I	N	aTc/aAc	0.36	0.03	0.01	possibly_damaging	0.85	deleterious	0	neutral	4.19	deleterious	-3.61	deleterious	-5.5	medium_impact	2.85	0.85	neutral	0.43	neutral	4.20	23.90	deleterious	0.27	0.65	0.84	disease	0.74	disease	0.57	disease	0.72	disease	4	1	deleterious	0.08	neutral	4	deleterious	0.73	deleterious	-1.47	low_impact	-1.4	low_impact	1.35	medium_impact	0.54	0.9	42.48	7.64	0.29	N	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9246	9246	A	G	MI.6730	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	40	14	S	G	Agc/Ggc	-10.28	0	0	probably_damaging	0.99	neutral	0.25	neutral	1.78	deleterious	-4.49	deleterious	-3.44	high_impact	4.14	0.57	damaging	0.06	damaging	3.41	23.00	deleterious	0.12	0.4	NA	NA	0.47	neutral	0.8	disease	0.69	disease	4	0.99	deleterious	0.13	neutral	2	deleterious	0.73	deleterious	-2.81	low_impact	-0.08	medium_impact	2.53	high_impact	0.41	0.8	73.95	11.54	0.4	N	0.83	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9246	9246	A	C	MI.6731	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	40	14	S	R	Agc/Cgc	-10.28	0	0	probably_damaging	1	neutral	0.26	neutral	1.77	deleterious	-5	deleterious	-4.3	high_impact	3.94	0.51	damaging	0.05	damaging	3.68	23.30	deleterious	0.05	0.35	NA	NA	0.73	disease	0.82	disease	0.79	disease	6	1	deleterious	0.13	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.07	medium_impact	2.35	high_impact	0.29	0.8	73.95	11.54	0.37	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9246	9246	A	T	MI.6732	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	40	14	S	C	Agc/Tgc	-10.28	0	0	probably_damaging	1	neutral	0.13	neutral	1.74	deleterious	-6.69	deleterious	-4.3	high_impact	4.49	0.61	neutral	0.03	damaging	3.27	22.80	deleterious	0.04	0.35	NA	NA	0.63	disease	0.79	disease	0.74	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	-0.28	medium_impact	2.84	high_impact	0.17	0.8	73.95	11.54	0.44	N	0.98	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9247	9247	G	C	MI.6733	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	41	14	S	T	aGc/aCc	8.69	1	0	probably_damaging	0.96	neutral	0.36	neutral	1.95	neutral	-2.32	deleterious	-2.58	high_impact	3.68	0.57	damaging	0.06	damaging	3.22	22.70	deleterious	0.2	0.45	NA	NA	0.56	disease	0.81	disease	0.77	disease	5	0.96	neutral	0.2	neutral	2	deleterious	0.71	deleterious	-2.21	low_impact	0.05	medium_impact	2.12	high_impact	0.49	0.8	73.95	11.54	0.61	P	0.63	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9247	9247	G	A	MI.6734	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	41	14	S	N	aGc/aAc	8.69	1	0	probably_damaging	0.96	neutral	0.23	neutral	1.82	deleterious	-3.72	deleterious	-2.57	high_impact	3.8	0.54	damaging	0.1	damaging	3.39	23.00	deleterious	0.24	0.45	NA	NA	0.62	disease	0.78	disease	0.74	disease	5	0.97	neutral	0.14	neutral	2	deleterious	0.73	deleterious	-2.21	low_impact	-0.11	medium_impact	2.22	high_impact	0.26	0.8	73.95	11.54	0.65	P	0.88	polymorphism	1	0.16	.	.	.	.	.	.	COSM6188307	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9247	9247	G	T	MI.6735	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	41	14	S	I	aGc/aTc	8.69	1	0	probably_damaging	1	neutral	0.36	neutral	1.75	deleterious	-6.09	deleterious	-5.16	high_impact	4.49	0.6	damaging	0.03	damaging	3.94	23.50	deleterious	0.04	0.35	NA	NA	0.8	disease	0.8	disease	0.79	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	0.05	medium_impact	2.84	high_impact	0.23	0.8	73.95	11.54	0.57	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9249	9249	C	A	MI.6736	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	43	15	P	T	Cca/Aca	1.52	1	0	probably_damaging	1	neutral	0.36	neutral	1.87	neutral	-2.95	deleterious	-6.9	high_impact	3.79	0.63	neutral	0.01	damaging	3.41	23.00	deleterious	0.26	0.45	NA	NA	0.76	disease	0.67	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.05	medium_impact	2.21	high_impact	0.44	0.8	73.95	11.6	0.36	N	0.93	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9249	9249	C	T	MI.6737	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	43	15	P	S	Cca/Tca	1.52	1	0	probably_damaging	1	neutral	0.48	neutral	1.95	neutral	-1.85	deleterious	-6.9	medium_impact	2.98	0.67	neutral	0.02	damaging	3.68	23.30	deleterious	0.26	0.45	NA	NA	0.74	disease	0.62	disease	0.62	disease	2	1	deleterious	0.24	neutral	1	deleterious	0.82	deleterious	-3.78	low_impact	0.17	medium_impact	1.49	medium_impact	0.26	0.8	73.95	11.6	0.28	N	0.79	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9249	9249	C	G	MI.6738	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	43	15	P	A	Cca/Gca	1.52	1	0	probably_damaging	0.98	neutral	0.47	neutral	1.92	neutral	-2.23	deleterious	-6.9	medium_impact	3.23	0.63	neutral	0.03	damaging	2.80	21.40	deleterious	0.22	0.45	NA	NA	0.58	disease	0.65	disease	0.65	disease	3	0.98	deleterious	0.25	neutral	1	deleterious	0.77	deleterious	-2.51	low_impact	0.16	medium_impact	1.71	medium_impact	0.46	0.8	73.95	11.6	0.33	N	0.70	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9250	9250	C	T	MI.6739	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	44	15	P	L	cCa/cTa	7.3	1	0	probably_damaging	1	neutral	0.62	neutral	1.83	deleterious	-3.84	deleterious	-8.62	medium_impact	3.02	0.59	damaging	0.02	damaging	4.16	23.80	deleterious	0.2	0.45	NA	NA	0.79	disease	0.63	disease	0.7	disease	4	1	deleterious	0.31	neutral	1	deleterious	0.82	deleterious	-3.78	low_impact	0.31	medium_impact	1.52	medium_impact	0.58	0.8	73.95	11.6	0.4	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8843	8843	T	G	MI.674	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	317	106	I	S	aTc/aGc	0.36	0.03	0.01	possibly_damaging	0.56	deleterious	0	neutral	4.22	neutral	-2.2	deleterious	-4.75	low_impact	1.8	0.83	neutral	0.44	neutral	2.66	20.50	deleterious	0.29	0.65	0.71	disease	0.72	disease	0.56	disease	0.68	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.51	deleterious	-0.86	medium_impact	-1.4	low_impact	0.45	medium_impact	0.45	0.9	42.48	7.64	0.32	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9250	9250	C	G	MI.6740	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	44	15	P	R	cCa/cGa	7.3	1	0	probably_damaging	1	neutral	0.32	neutral	1.83	deleterious	-3.78	deleterious	-7.76	medium_impact	3.05	0.74	neutral	0.02	damaging	3.35	22.90	deleterious	0.14	0.4	NA	NA	0.83	disease	0.69	disease	0.74	disease	5	1	deleterious	0.16	neutral	1	deleterious	0.85	deleterious	-3.78	low_impact	0.01	medium_impact	1.55	medium_impact	0.27	0.8	73.95	11.6	0.42	N	0.93	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9250	9250	C	A	MI.6741	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	44	15	P	Q	cCa/cAa	7.3	1	0	probably_damaging	1	neutral	0.27	neutral	1.83	deleterious	-3.83	deleterious	-6.9	high_impact	3.98	0.68	neutral	0.02	damaging	3.90	23.50	deleterious	0.18	0.45	NA	NA	0.82	disease	0.67	disease	0.73	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.06	medium_impact	2.38	high_impact	0.22	0.8	73.95	11.6	0.49	N	0.86	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9252	9252	T	G	MI.6742	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	46	16	W	G	Tga/Gga	-12.37	0	0	probably_damaging	1	neutral	0.33	neutral	1.79	deleterious	-5.36	deleterious	-11.27	high_impact	4.12	0.62	neutral	0.02	damaging	3.68	23.30	deleterious	0.05	0.35	NA	NA	0.79	disease	0.75	disease	0.76	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.02	medium_impact	2.51	high_impact	0.13	0.8	73.95	11.63	0.35	N	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9252	9252	T	C	MI.6743	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	46	16	W	R	Tga/Cga	-12.37	0	0	probably_damaging	1	neutral	0.35	neutral	1.8	deleterious	-4.86	deleterious	-12.14	high_impact	3.92	0.74	neutral	0.03	damaging	3.32	22.90	deleterious	0.04	0.35	NA	NA	0.87	disease	0.77	disease	0.79	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	0.04	medium_impact	2.33	high_impact	0.09	0.8	73.95	11.63	0.42	N	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9253	9253	G	T	MI.6744	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	47	16	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	neutral	0.65	neutral	1.86	deleterious	-3.02	deleterious	-11.27	medium_impact	2.8	0.61	neutral	0.02	damaging	4.00	23.60	deleterious	0.06	0.35	NA	NA	0.79	disease	0.74	disease	0.75	disease	5	0.99	deleterious	0.33	neutral	1	deleterious	0.81	deleterious	-3.78	low_impact	0.35	medium_impact	1.33	medium_impact	0.09	0.8	73.95	11.63	0.42	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9253	9253	G	C	MI.6745	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	47	16	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	neutral	0.4	neutral	1.81	deleterious	-4.36	deleterious	-12.14	high_impact	4.46	0.66	neutral	0.03	damaging	3.76	23.30	deleterious	0.04	0.35	NA	NA	0.88	disease	0.74	disease	0.79	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	0.09	medium_impact	2.81	high_impact	0.10	0.8	73.95	11.63	0.49	N	0.97	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9254	9254	A	T	MI.6746	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	48	16	W	C	tgA/tgT	9.15	1	0.02	probably_damaging	1	neutral	0.18	neutral	1.78	deleterious	-6.17	deleterious	-11.26	high_impact	4.46	0.67	neutral	0.02	damaging	3.89	23.50	deleterious	0.04	0.35	NA	NA	0.85	disease	0.77	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.18	medium_impact	2.81	high_impact	0.14	0.8	73.95	11.63	0.49	N	1.00	polymorphism	1	0.36	rs386829072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9254	9254	A	C	MI.6747	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	48	16	W	C	tgA/tgC	9.15	1	0.02	probably_damaging	1	neutral	0.18	neutral	1.78	deleterious	-6.17	deleterious	-11.26	high_impact	4.46	0.67	neutral	0.02	damaging	3.76	23.30	deleterious	0.04	0.35	NA	NA	0.85	disease	0.77	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.18	medium_impact	2.81	high_impact	0.14	0.8	73.95	11.63	0.48	N	1.00	polymorphism	1	0.36	rs386829072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9255	9255	C	G	MI.6748	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	49	17	P	A	Ccc/Gcc	1.05	1	0	probably_damaging	0.98	neutral	0.5	neutral	0.61	deleterious	-6.48	deleterious	-6.95	medium_impact	3.41	0.63	neutral	0.02	damaging	2.82	21.50	deleterious	0.07	0.35	NA	NA	0.58	disease	0.68	disease	0.68	disease	4	0.98	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-2.51	low_impact	0.19	medium_impact	1.87	medium_impact	0.59	0.8	73.95	11.72	0.34	N	0.70	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9255	9255	C	A	MI.6749	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	49	17	P	T	Ccc/Acc	1.05	1	0	probably_damaging	1	neutral	0.4	neutral	0.58	deleterious	-7.59	deleterious	-6.95	medium_impact	3.27	0.63	neutral	0.01	damaging	3.44	23.00	deleterious	0.05	0.35	NA	NA	0.74	disease	0.67	disease	0.69	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	0.09	medium_impact	1.75	medium_impact	0.48	0.8	73.95	11.72	0.3	N	0.93	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8844	8844	C	G	MI.675	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	318	106	I	M	atC/atG	4.76	0.83	0.01	possibly_damaging	0.74	neutral	0.2	neutral	4.24	neutral	-1.67	neutral	-2.15	low_impact	1.05	0.85	neutral	0.45	neutral	3.09	22.50	deleterious	0.44	0.65	0.54	disease	0.43	neutral	0.32	neutral	0.47	neutral	1	0.86	neutral	0.23	neutral	-3	neutral	0.55	deleterious	-1.19	low_impact	-0.05	medium_impact	-0.2	medium_impact	0.71	0.9	42.48	7.64	0.41	N	0.75	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9255	9255	C	T	MI.6750	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	49	17	P	S	Ccc/Tcc	1.05	1	0	probably_damaging	1	neutral	0.41	neutral	0.6	deleterious	-6.81	deleterious	-6.95	high_impact	3.7	0.68	neutral	0.02	damaging	3.71	23.30	deleterious	0.04	0.35	NA	NA	0.74	disease	0.66	disease	0.69	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.1	medium_impact	2.13	high_impact	0.12	0.8	73.95	11.72	0.38	N	0.79	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9256	9256	C	T	MI.6751	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	50	17	P	L	cCc/cTc	5.45	1	0	probably_damaging	1	neutral	0.67	neutral	0.58	deleterious	-7.49	deleterious	-8.69	high_impact	3.96	0.6	damaging	0.02	damaging	4.13	23.80	deleterious	0.03	0.35	NA	NA	0.81	disease	0.64	disease	0.7	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.37	medium_impact	2.37	high_impact	0.67	0.85	73.95	11.72	0.42	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	COSM6716206	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9256	9256	C	G	MI.6752	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	50	17	P	R	cCc/cGc	5.45	1	0	probably_damaging	1	neutral	0.35	neutral	0.58	deleterious	-7.98	deleterious	-7.82	high_impact	4.51	0.75	neutral	0.02	damaging	3.38	23.00	deleterious	0.03	0.35	NA	NA	0.83	disease	0.76	disease	0.78	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	0.04	medium_impact	2.86	high_impact	0.25	0.8	73.95	11.72	0.49	N	0.93	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9256	9256	C	A	MI.6753	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	50	17	P	H	cCc/cAc	5.45	1	0	probably_damaging	1	neutral	0.54	neutral	0.57	deleterious	-9.26	deleterious	-7.82	high_impact	4.51	0.61	neutral	0.02	damaging	3.91	23.50	deleterious	0.03	0.35	NA	NA	0.79	disease	0.75	disease	0.76	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.23	medium_impact	2.86	high_impact	0.28	0.8	73.95	11.72	0.45	N	0.88	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9258	9258	C	A	MI.6754	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	52	18	L	M	Cta/Ata	-11.21	0	0	probably_damaging	1	neutral	0.23	neutral	2	neutral	-2.44	neutral	-1.36	medium_impact	2.69	0.51	damaging	0.05	damaging	3.53	23.10	deleterious	0.28	0.45	NA	NA	0.39	neutral	0.41	neutral	0.19	neutral	6	1	deleterious	0.12	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.11	medium_impact	1.23	medium_impact	0.63	0.8	75.48	11.59	0.35	N	0.85	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9258	9258	C	G	MI.6755	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	52	18	L	V	Cta/Gta	-11.21	0	0	probably_damaging	0.98	neutral	0.51	neutral	2.08	neutral	-0.78	neutral	-1.81	low_impact	1.94	0.53	damaging	0.06	damaging	3.22	22.70	deleterious	0.24	0.45	NA	NA	0.42	neutral	0.29	neutral	0.22	neutral	6	0.97	neutral	0.27	neutral	-2	neutral	0.71	deleterious	-2.51	low_impact	0.2	medium_impact	0.56	medium_impact	0.55	0.8	75.48	11.59	0.28	N	0.81	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9259	9259	T	C	MI.6756	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	53	18	L	P	cTa/cCa	-0.33	0	0	probably_damaging	1	neutral	0.31	neutral	1.94	deleterious	-4.75	deleterious	-5.58	high_impact	3.89	0.45	damaging	0.02	damaging	3.69	23.30	deleterious	0.03	0.35	NA	NA	0.77	disease	0.66	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.01	medium_impact	2.3	high_impact	0.31	0.8	75.48	11.59	0.32	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9259	9259	T	G	MI.6757	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	53	18	L	R	cTa/cGa	-0.33	0	0	probably_damaging	1	neutral	0.34	neutral	1.95	deleterious	-4.19	deleterious	-4.89	high_impact	3.89	0.46	damaging	0.02	damaging	3.94	23.50	deleterious	0.02	0.35	NA	NA	0.81	disease	0.67	disease	0.72	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	0.03	medium_impact	2.3	high_impact	0.19	0.8	75.48	11.59	0.34	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9259	9259	T	A	MI.6758	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	53	18	L	Q	cTa/cAa	-0.33	0	0	probably_damaging	1	neutral	0.29	neutral	1.95	deleterious	-4.28	deleterious	-4.84	high_impact	3.89	0.47	damaging	0.02	damaging	3.86	23.40	deleterious	0.03	0.35	NA	NA	0.7	disease	0.54	disease	0.65	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	-0.03	medium_impact	2.3	high_impact	0.30	0.8	75.48	11.59	0.35	N	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9261	9261	A	T	MI.6759	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	55	19	T	S	Aca/Tca	-8.2	0	0.01	benign	0.06	neutral	0.43	neutral	2.52	neutral	-0.29	deleterious	-2.76	medium_impact	2.32	0.66	neutral	0.57	neutral	1.25	11.99	neutral	0.32	0.5	NA	NA	0.33	neutral	0.36	neutral	0.18	neutral	6	0.53	neutral	0.69	deleterious	-3	neutral	0.16	neutral	0.29	medium_impact	0.12	medium_impact	0.9	medium_impact	0.70	0.85	75.1	10.9	0.38	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8844	8844	C	A	MI.676	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	318	106	I	M	atC/atA	4.76	0.83	0.01	possibly_damaging	0.74	neutral	0.2	neutral	4.24	neutral	-1.67	neutral	-2.15	low_impact	1.05	0.85	neutral	0.45	neutral	3.53	23.10	deleterious	0.44	0.65	0.54	disease	0.43	neutral	0.32	neutral	0.47	neutral	1	0.86	neutral	0.23	neutral	-3	neutral	0.55	deleterious	-1.19	low_impact	-0.05	medium_impact	-0.2	medium_impact	0.71	0.9	42.48	7.64	0.41	N	0.75	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9261	9261	A	C	MI.6760	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	55	19	T	P	Aca/Cca	-8.2	0	0.01	possibly_damaging	0.48	neutral	0.21	neutral	2.5	neutral	-1.67	deleterious	-4.24	medium_impact	3.12	0.58	damaging	0.41	neutral	3.14	22.60	deleterious	0.07	0.35	NA	NA	0.7	disease	0.53	disease	0.61	disease	2	0.77	neutral	0.37	neutral	0	NA	0.60	deleterious	-0.84	medium_impact	-0.14	medium_impact	1.61	medium_impact	0.43	0.8	75.1	10.9	0.37	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9261	9261	A	G	MI.6761	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	55	19	T	A	Aca/Gca	-8.2	0	0.01	benign	0	neutral	0.52	neutral	2.55	neutral	0.45	deleterious	-3.08	medium_impact	2.02	0.7	neutral	0.75	neutral	1.27	12.12	neutral	0.32	0.5	NA	NA	0.29	neutral	0.36	neutral	0.19	neutral	6	0.47	neutral	0.76	deleterious	-3	neutral	0.12	neutral	2.05	high_impact	0.21	medium_impact	0.63	medium_impact	0.40	0.8	75.1	10.9	0.38	N	0.44	polymorphism	1	0.07	.	.	.	.	.	pituitary adenoma	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9262	9262	C	T	MI.6762	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	56	19	T	M	aCa/aTa	3.83	0.99	0	possibly_damaging	0.86	neutral	0.23	neutral	2.52	neutral	0.03	deleterious	-3.27	low_impact	1.48	0.7	neutral	0.66	neutral	3.68	23.30	deleterious	0.13	0.4	NA	NA	0.38	neutral	0.28	neutral	0.21	neutral	6	0.91	neutral	0.19	neutral	-3	neutral	0.66	deleterious	-1.64	low_impact	-0.11	medium_impact	0.14	medium_impact	0.63	0.8	75.1	10.9	0.5	P	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9262	9262	C	A	MI.6763	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	56	19	T	K	aCa/aAa	3.83	0.99	0	benign	0.14	neutral	0.29	neutral	2.51	neutral	-1.19	deleterious	-4.11	medium_impact	3.47	0.64	neutral	0.42	neutral	3.85	23.40	deleterious	0.07	0.35	NA	NA	0.64	disease	0.51	disease	0.55	disease	1	0.66	neutral	0.58	deleterious	-3	neutral	0.47	deleterious	-0.1	medium_impact	-0.03	medium_impact	1.93	medium_impact	0.58	0.8	75.1	10.9	0.57	P	0.99	polymorphism	1	0.16	rs386829073	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9264	9264	G	C	MI.6764	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	58	20	G	R	Ggg/Cgg	-2.42	0	0	probably_damaging	1	neutral	0.36	neutral	2.28	neutral	-0.96	deleterious	-6.04	high_impact	3.9	0.63	neutral	0.01	damaging	3.77	23.40	deleterious	0.04	0.35	NA	NA	0.72	disease	0.71	disease	0.72	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	0.05	medium_impact	2.31	high_impact	0.63	0.8	74.71	11.58	0.29	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9264	9264	G	T	MI.6765	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	58	20	G	W	Ggg/Tgg	-2.42	0	0	probably_damaging	1	neutral	0.19	neutral	2.24	deleterious	-3.23	deleterious	-6.31	high_impact	3.9	0.63	neutral	0.01	damaging	4.22	23.90	deleterious	0.06	0.35	NA	NA	0.72	disease	0.64	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.17	medium_impact	2.31	high_impact	0.23	0.8	74.71	11.58	0.3	N	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9265	9265	G	T	MI.6766	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	59	20	G	V	gGg/gTg	6.14	1	0	probably_damaging	1	neutral	0.51	neutral	2.46	neutral	1.35	deleterious	-6.71	medium_impact	2.26	0.53	damaging	0.03	damaging	3.55	23.10	deleterious	0.08	0.35	NA	NA	0.57	disease	0.41	neutral	0.46	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.2	medium_impact	0.84	medium_impact	0.20	0.8	74.71	11.58	0.41	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9265	9265	G	A	MI.6767	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	59	20	G	E	gGg/gAg	6.14	1	0	probably_damaging	1	neutral	0.28	neutral	2.29	neutral	-0.6	deleterious	-6.01	high_impact	3.56	0.62	neutral	0.01	damaging	3.71	23.30	deleterious	0.04	0.35	NA	NA	0.69	disease	0.7	disease	0.69	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.04	medium_impact	2.01	high_impact	0.35	0.8	74.71	11.58	0.55	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9265	9265	G	C	MI.6768	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	59	20	G	A	gGg/gCg	6.14	1	0	probably_damaging	1	neutral	0.53	neutral	2.37	neutral	0.62	deleterious	-3.99	low_impact	1.17	0.55	damaging	0.1	damaging	1.82	15.09	deleterious	0.17	0.45	NA	NA	0.25	neutral	0.29	neutral	0.2	neutral	6	1	deleterious	0.27	neutral	-2	neutral	0.73	deleterious	-3.78	low_impact	0.22	medium_impact	-0.13	medium_impact	0.56	0.8	74.71	11.58	0.45	N	0.30	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9267	9267	G	T	MI.6769	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	61	21	A	S	Gcc/Tcc	-1.72	0	0	probably_damaging	0.99	neutral	0.82	neutral	2.58	neutral	0	neutral	-1.15	neutral_impact	-0.06	0.54	damaging	0.07	damaging	2.35	18.47	deleterious	0.25	0.45	NA	NA	0.07	neutral	0.25	neutral	0.22	neutral	6	0.99	deleterious	0.42	neutral	-2	neutral	0.69	deleterious	-2.81	low_impact	0.57	medium_impact	-1.24	low_impact	0.62	0.8	74.33	11.65	0.26	N	0.89	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8845	8845	C	T	MI.677	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	319	107	P	S	Ccc/Tcc	-6.58	0	0	probably_damaging	1	neutral	0.15	neutral	4.39	neutral	0.56	deleterious	-7.55	medium_impact	2.24	0.72	neutral	0.19	damaging	3.86	23.50	deleterious	0.49	0.65	0.38	neutral	0.85	disease	0.64	disease	0.45	neutral	1	1	deleterious	0.08	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.13	medium_impact	0.82	medium_impact	0.28	0.9	48.67	8.6	0.28	N	0.82	disease_causing	0.87	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9267	9267	G	C	MI.6770	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	61	21	A	P	Gcc/Ccc	-1.72	0	0	probably_damaging	1	neutral	0.27	neutral	2.22	deleterious	-3.66	deleterious	-3.59	high_impact	3.77	0.53	damaging	0.03	damaging	3.62	23.20	deleterious	0.03	0.35	NA	NA	0.75	disease	0.65	disease	0.68	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.06	medium_impact	2.2	high_impact	0.71	0.85	74.33	11.65	0.33	N	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	G9267C	MIDD	-	+	Reported	1	.	P	P	damaging
chrM	9267	9267	G	A	MI.6771	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	61	21	A	T	Gcc/Acc	-1.72	0	0	probably_damaging	0.99	neutral	0.62	neutral	2.25	neutral	-2.81	neutral	-2.49	medium_impact	2.36	0.53	damaging	0.03	damaging	4.00	23.60	deleterious	0.11	0.4	NA	NA	0.46	neutral	0.58	disease	0.44	neutral	1	0.99	deleterious	0.32	neutral	1	deleterious	0.73	deleterious	-2.81	low_impact	0.31	medium_impact	0.93	medium_impact	0.78	0.85	74.33	11.65	0.24	N	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9268	9268	C	A	MI.6772	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	62	21	A	D	gCc/gAc	7.3	1	0	probably_damaging	1	neutral	0.21	neutral	2.24	deleterious	-3.09	deleterious	-3.95	high_impact	3.77	0.55	damaging	0.01	damaging	4.26	23.90	deleterious	0.02	0.35	NA	NA	0.76	disease	0.7	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.14	medium_impact	2.2	high_impact	0.42	0.8	74.33	11.65	0.56	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9268	9268	C	T	MI.6773	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	62	21	A	V	gCc/gTc	7.3	1	0	probably_damaging	0.99	neutral	0.63	neutral	2.23	deleterious	-3.26	deleterious	-3.23	medium_impact	2.88	0.5	damaging	0.03	damaging	4.30	24.00	deleterious	0.07	0.35	NA	NA	0.52	disease	0.59	disease	0.66	disease	3	0.99	deleterious	0.32	neutral	1	deleterious	0.75	deleterious	-2.81	low_impact	0.32	medium_impact	1.4	medium_impact	0.75	0.85	74.33	11.65	0.51	P	0.87	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9268	9268	C	G	MI.6774	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	62	21	A	G	gCc/gGc	7.3	1	0	probably_damaging	0.98	neutral	0.82	neutral	2.32	neutral	-1.74	deleterious	-2.54	medium_impact	2.19	0.5	damaging	0.05	damaging	3.69	23.30	deleterious	0.19	0.45	NA	NA	0.36	neutral	0.34	neutral	0.17	neutral	7	0.97	neutral	0.42	neutral	1	deleterious	0.71	deleterious	-2.51	low_impact	0.57	medium_impact	0.78	medium_impact	0.70	0.85	74.33	11.65	0.47	N	0.67	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9270	9270	C	G	MI.6775	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	64	22	L	V	Ctc/Gtc	-9.82	0	0	benign	0.1	neutral	0.54	neutral	2.31	neutral	-0.05	neutral	0.02	neutral_impact	0.07	0.75	neutral	0.81	neutral	-0.02	2.44	deleterious	0.3	0.45	NA	NA	0.12	neutral	0.25	neutral	0.24	neutral	5	0.38	neutral	0.72	deleterious	-6	neutral	0.12	neutral	0.06	medium_impact	0.23	medium_impact	-1.12	low_impact	0.75	0.85	69.35	10.21	0.39	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9270	9270	C	A	MI.6776	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	64	22	L	I	Ctc/Atc	-9.82	0	0	benign	0.23	neutral	0.5	neutral	2.31	neutral	-0.05	neutral	0.24	neutral_impact	-0.22	0.77	neutral	0.81	neutral	0.92	10.22	neutral	0.34	0.5	NA	NA	0.04	neutral	0.16	neutral	0.18	neutral	6	0.4	neutral	0.64	deleterious	-6	neutral	0.14	neutral	-0.36	medium_impact	0.19	medium_impact	-1.38	low_impact	0.61	0.8	69.35	10.21	0.5	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9270	9270	C	T	MI.6777	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	64	22	L	F	Ctc/Ttc	-9.82	0	0	benign	0.01	neutral	0.68	neutral	2.22	neutral	-0.74	neutral	-1.03	neutral_impact	0.7	0.78	neutral	0.77	neutral	0.76	9.23	deleterious	0.29	0.45	NA	NA	0.15	neutral	0.21	neutral	0.22	neutral	6	0.29	neutral	0.84	deleterious	-6	neutral	0.09	neutral	1.07	medium_impact	0.38	medium_impact	-0.56	medium_impact	0.74	0.85	69.35	10.21	0.34	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9271	9271	T	A	MI.6778	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	65	22	L	H	cTc/cAc	-0.8	0	0	probably_damaging	0.91	neutral	0.46	neutral	2.08	deleterious	-3.91	deleterious	-3.03	medium_impact	2.98	0.69	neutral	0.48	neutral	3.85	23.40	deleterious	0.04	0.35	NA	NA	0.43	neutral	0.53	disease	0.39	neutral	2	0.91	neutral	0.28	neutral	1	deleterious	0.67	deleterious	-1.85	low_impact	0.15	medium_impact	1.49	medium_impact	0.33	0.8	69.35	10.21	0.35	N	0.84	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9271	9271	T	G	MI.6779	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	65	22	L	R	cTc/cGc	-0.8	0	0	possibly_damaging	0.83	neutral	0.29	neutral	2.09	deleterious	-3.26	deleterious	-2.8	medium_impact	2.98	0.61	neutral	0.43	neutral	3.94	23.50	deleterious	0.02	0.35	NA	NA	0.61	disease	0.65	disease	0.72	disease	4	0.87	neutral	0.23	neutral	0	NA	0.70	deleterious	-1.54	low_impact	-0.03	medium_impact	1.49	medium_impact	0.36	0.8	69.35	10.21	0.36	N	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8845	8845	C	A	MI.678	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	319	107	P	T	Ccc/Acc	-6.58	0	0	probably_damaging	1	neutral	0.16	neutral	4.37	neutral	1.03	deleterious	-7.56	medium_impact	2.07	0.67	neutral	0.16	damaging	3.65	23.20	deleterious	0.32	0.65	0.36	neutral	0.84	disease	0.61	disease	0.45	neutral	1	1	deleterious	0.08	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.12	medium_impact	0.68	medium_impact	0.84	0.9	48.67	8.6	0.27	N	0.93	disease_causing	0.86	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9271	9271	T	C	MI.6780	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	65	22	L	P	cTc/cCc	-0.8	0	0	probably_damaging	0.94	neutral	0.29	neutral	2.08	deleterious	-3.89	deleterious	-3.06	medium_impact	2.63	0.56	damaging	0.36	neutral	3.65	23.20	deleterious	0.02	0.35	NA	NA	0.66	disease	0.66	disease	0.72	disease	4	0.95	neutral	0.18	neutral	1	deleterious	0.75	deleterious	-2.03	low_impact	-0.03	medium_impact	1.17	medium_impact	0.40	0.8	69.35	10.21	0.31	N	0.83	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9273	9273	T	G	MI.6781	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	67	23	S	A	Tca/Gca	-9.13	0	0	probably_damaging	0.96	neutral	0.63	neutral	2.23	neutral	-0.49	neutral	-0.16	neutral_impact	0	0.63	neutral	0.56	neutral	0.77	9.28	deleterious	0.24	0.45	NA	NA	0.09	neutral	0.28	neutral	0.24	neutral	5	0.95	neutral	0.34	neutral	-2	neutral	0.54	deleterious	-2.21	low_impact	0.32	medium_impact	-1.18	low_impact	0.52	0.8	74.33	11.74	0.35	N	0.40	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9273	9273	T	C	MI.6782	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	67	23	S	P	Tca/Cca	-9.13	0	0	probably_damaging	0.99	neutral	0.22	neutral	2.01	deleterious	-3.51	deleterious	-2.51	medium_impact	2.54	0.39	damaging	0.1	damaging	3.76	23.40	deleterious	0.05	0.35	NA	NA	0.79	disease	0.68	disease	0.75	disease	5	0.99	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	-0.12	medium_impact	1.09	medium_impact	0.37	0.8	74.33	11.74	0.36	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9273	9273	T	A	MI.6783	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	67	23	S	T	Tca/Aca	-9.13	0	0	probably_damaging	0.92	neutral	0.4	neutral	2.07	neutral	-1.94	neutral	-1.74	medium_impact	2	0.51	damaging	0.19	damaging	3.44	23.00	deleterious	0.21	0.45	NA	NA	0.27	neutral	0.56	disease	0.36	neutral	3	0.92	neutral	0.24	neutral	1	deleterious	0.63	deleterious	-1.9	low_impact	0.09	medium_impact	0.61	medium_impact	0.64	0.8	74.33	11.74	0.39	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9274	9274	C	T	MI.6784	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	68	23	S	L	tCa/tTa	4.52	1	0	probably_damaging	0.99	neutral	0.73	neutral	2.04	neutral	-2.51	deleterious	-3.61	medium_impact	2.89	0.43	damaging	0.07	damaging	4.47	24.20	deleterious	0.05	0.35	NA	NA	0.63	disease	0.52	disease	0.6	disease	2	0.99	deleterious	0.37	neutral	1	deleterious	0.74	deleterious	-2.81	low_impact	0.44	medium_impact	1.41	medium_impact	0.57	0.8	74.33	11.74	0.59	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9274	9274	C	G	MI.6785	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	68	23	S	W	tCa/tGa	4.52	1	0	probably_damaging	1	neutral	0.2	neutral	1.98	deleterious	-5.9	deleterious	-3.41	medium_impact	3.24	0.44	damaging	0.09	damaging	4.15	23.80	deleterious	0.06	0.35	NA	NA	0.74	disease	0.56	disease	0.7	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	-0.15	medium_impact	1.72	medium_impact	0.19	0.8	74.33	11.74	0.49	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9276	9276	G	A	MI.6786	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	70	24	A	T	Gcc/Acc	-5.66	0	0	benign	0.02	neutral	0.42	neutral	2.46	neutral	-1.27	deleterious	-2.71	medium_impact	2.6	0.51	damaging	0.75	neutral	2.07	16.65	deleterious	0.18	0.45	NA	NA	0.48	neutral	0.32	neutral	0.32	neutral	4	0.56	neutral	0.7	deleterious	-3	neutral	0.16	neutral	0.77	medium_impact	0.11	medium_impact	1.15	medium_impact	0.74	0.85	74.71	11.6	0.5	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9276	9276	G	T	MI.6787	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	70	24	A	S	Gcc/Tcc	-5.66	0	0	benign	0.34	neutral	0.44	neutral	2.44	neutral	-1.21	neutral	-2.02	low_impact	1.86	0.59	damaging	0.71	neutral	2.18	17.39	deleterious	0.26	0.45	NA	NA	0.48	neutral	0.31	neutral	0.29	neutral	4	0.48	neutral	0.55	deleterious	-6	neutral	0.27	neutral	-0.59	medium_impact	0.13	medium_impact	0.48	medium_impact	0.37	0.8	74.71	11.6	0.39	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9276	9276	G	C	MI.6788	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	70	24	A	P	Gcc/Ccc	-5.66	0	0	possibly_damaging	0.8	neutral	0.22	neutral	2.42	neutral	-2.88	deleterious	-3.94	high_impact	3.96	0.57	damaging	0.43	neutral	3.61	23.20	deleterious	0.04	0.35	NA	NA	0.77	disease	0.67	disease	0.7	disease	4	0.87	neutral	0.21	neutral	1	deleterious	0.74	deleterious	-1.45	low_impact	-0.12	medium_impact	2.37	high_impact	0.65	0.8	74.71	11.6	0.42	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9277	9277	C	G	MI.6789	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	71	24	A	G	gCc/gGc	3.6	1	0	benign	0.21	neutral	0.41	neutral	2.43	neutral	-2.23	deleterious	-3.12	medium_impact	1.97	0.59	damaging	0.78	neutral	3.50	23.10	deleterious	0.24	0.45	NA	NA	0.38	neutral	0.3	neutral	0.19	neutral	6	0.51	neutral	0.6	deleterious	-3	neutral	0.26	neutral	-0.31	medium_impact	0.1	medium_impact	0.58	medium_impact	0.75	0.85	74.71	11.6	0.52	P	0.67	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8845	8845	C	G	MI.679	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	319	107	P	A	Ccc/Gcc	-6.58	0	0	probably_damaging	1	deleterious	0.02	neutral	4.35	neutral	0.92	deleterious	-7.56	medium_impact	2.98	0.66	neutral	0.17	damaging	3.06	22.40	deleterious	0.35	0.65	0.51	disease	0.77	disease	0.65	disease	0.67	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-3.6	low_impact	-0.66	medium_impact	1.46	medium_impact	0.75	0.9	48.67	8.6	0.28	N	0.79	disease_causing	0.8	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9277	9277	C	A	MI.6790	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	71	24	A	D	gCc/gAc	3.6	1	0	possibly_damaging	0.68	neutral	0.2	neutral	2.4	neutral	-2.8	deleterious	-4.63	high_impact	3.61	0.59	damaging	0.48	neutral	4.36	24.10	deleterious	0.02	0.35	NA	NA	0.8	disease	0.65	disease	0.7	disease	4	0.83	neutral	0.26	neutral	1	deleterious	0.69	deleterious	-1.19	low_impact	-0.15	medium_impact	2.05	high_impact	0.46	0.8	74.71	11.6	0.53	P	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9277	9277	C	T	MI.6791	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	71	24	A	V	gCc/gTc	3.6	1	0	benign	0.24	neutral	0.52	neutral	2.52	neutral	-0.55	deleterious	-3.13	low_impact	1.72	0.54	damaging	0.77	neutral	4.00	23.60	deleterious	0.19	0.45	NA	NA	0.49	neutral	0.33	neutral	0.33	neutral	3	0.37	neutral	0.64	deleterious	-6	neutral	0.48	deleterious	-0.38	medium_impact	0.21	medium_impact	0.36	medium_impact	0.74	0.85	74.71	11.6	0.51	P	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9279	9279	C	T	MI.6792	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	73	25	L	F	Ctc/Ttc	-2.19	0	0	benign	0.02	neutral	0.85	neutral	2.45	neutral	-0.79	neutral	-1.34	neutral_impact	0.54	0.74	neutral	0.92	neutral	0.52	7.60	deleterious	0.38	0.5	NA	NA	0.15	neutral	0.27	neutral	0.22	neutral	6	0.09	neutral	0.92	deleterious	-6	neutral	0.12	neutral	0.77	medium_impact	0.62	medium_impact	-0.7	medium_impact	0.52	0.8	23.37	18.52	0.32	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9279	9279	C	A	MI.6793	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	73	25	L	I	Ctc/Atc	-2.19	0	0	benign	0.34	neutral	0.49	neutral	2.4	neutral	-1.75	neutral	-1.16	medium_impact	2.67	0.66	neutral	0.1	damaging	3.54	23.10	deleterious	0.33	0.5	NA	NA	0.51	disease	0.44	neutral	0.46	neutral	1	0.43	neutral	0.58	deleterious	-3	neutral	0.23	neutral	-0.59	medium_impact	0.18	medium_impact	1.21	medium_impact	0.55	0.8	23.37	18.52	0.27	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9279	9279	C	G	MI.6794	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	73	25	L	V	Ctc/Gtc	-2.19	0	0	benign	0.16	neutral	0.56	neutral	2.41	neutral	-1.57	neutral	-1.77	medium_impact	2.56	0.61	neutral	0.07	damaging	1.55	13.60	neutral	0.33	0.5	NA	NA	0.38	neutral	0.54	disease	0.38	neutral	2	0.33	neutral	0.7	deleterious	-3	neutral	0.18	neutral	-0.17	medium_impact	0.25	medium_impact	1.11	medium_impact	0.66	0.8	23.37	18.52	0.22	N	0.55	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9280	9280	T	C	MI.6795	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	74	25	L	P	cTc/cCc	0.59	0.07	0	probably_damaging	1	neutral	0.3	neutral	2.34	deleterious	-4.61	deleterious	-4.91	high_impact	3.57	0.52	damaging	0.02	damaging	3.70	23.30	deleterious	0.02	0.35	NA	NA	0.8	disease	0.68	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.02	medium_impact	2.02	high_impact	0.46	0.8	23.37	18.52	0.33	N	0.91	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9280	9280	T	G	MI.6796	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	74	25	L	R	cTc/cGc	0.59	0.07	0	probably_damaging	0.99	neutral	0.33	neutral	2.36	deleterious	-3.91	deleterious	-4.04	high_impact	3.92	0.54	damaging	0.02	damaging	3.99	23.60	deleterious	0.02	0.35	NA	NA	0.82	disease	0.68	disease	0.72	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-2.81	low_impact	0.02	medium_impact	2.33	high_impact	0.28	0.8	23.37	18.52	0.35	N	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9280	9280	T	A	MI.6797	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	74	25	L	H	cTc/cAc	0.59	0.07	0	probably_damaging	0.99	neutral	0.55	neutral	2.33	deleterious	-4.55	deleterious	-4.39	high_impact	3.92	0.61	neutral	0.05	damaging	3.91	23.50	deleterious	0.04	0.35	NA	NA	0.66	disease	0.64	disease	0.68	disease	4	0.99	deleterious	0.28	neutral	2	deleterious	0.74	deleterious	-2.81	low_impact	0.24	medium_impact	2.33	high_impact	0.28	0.8	23.37	18.52	0.28	N	0.87	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9282	9282	C	G	MI.6798	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	76	26	L	V	Cta/Gta	-16.07	0	0	benign	0.08	neutral	0.46	neutral	2.5	neutral	-0.46	neutral	-0.56	low_impact	1.27	0.68	neutral	0.63	neutral	0.51	7.54	deleterious	0.25	0.45	NA	NA	0.21	neutral	0.19	neutral	0.19	neutral	6	0.48	neutral	0.69	deleterious	-6	neutral	0.17	neutral	0.16	medium_impact	0.15	medium_impact	-0.04	medium_impact	0.52	0.8	75.1	11.41	0.51	N	0.81	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9282	9282	C	A	MI.6799	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	76	26	L	M	Cta/Ata	-16.07	0	0	possibly_damaging	0.81	neutral	0.52	neutral	2.44	neutral	-1.92	neutral	-0.04	low_impact	0.9	0.71	neutral	0.71	neutral	2.26	17.89	deleterious	0.23	0.45	NA	NA	0.19	neutral	0.18	neutral	0.21	neutral	6	0.78	neutral	0.36	neutral	-3	neutral	0.62	deleterious	-1.48	low_impact	0.21	medium_impact	-0.38	medium_impact	0.51	0.8	75.1	11.41	0.45	N	0.85	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8556	8556	T	A	MI.68	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	30	10	I	M	atT/atA	-0.33	0	0	benign	0.04	neutral	0.29	neutral	4.68	neutral	-1.06	neutral	0.07	neutral_impact	0.21	0.9	neutral	0.93	neutral	8.35	35.00	deleterious	0.43	0.65	0.6	disease	0.09	neutral	0.18	neutral	0.36	neutral	3	0.69	neutral	0.63	deleterious	-6	neutral	0.19	neutral	0.55	medium_impact	0.07	medium_impact	-0.92	medium_impact	0.40	0.9	27.43	16.7	0.59	P	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8846	8846	C	T	MI.680	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	320	107	P	L	cCc/cTc	5.68	1	0	probably_damaging	1	neutral	0.07	neutral	4.49	neutral	1.8	deleterious	-9.45	medium_impact	2.6	0.59	damaging	0.13	damaging	4.40	24.10	deleterious	0.44	0.65	0.27	neutral	0.91	disease	0.63	disease	0.71	disease	4	1	deleterious	0.04	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.34	medium_impact	1.13	medium_impact	0.78	0.9	48.67	8.6	0.43	N	0.95	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9283	9283	T	G	MI.6800	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	77	26	L	R	cTa/cGa	-0.33	0	0	possibly_damaging	0.52	neutral	0.26	neutral	2.43	deleterious	-3.12	deleterious	-2.66	medium_impact	3.15	0.55	damaging	0.3	neutral	3.90	23.50	deleterious	0.03	0.35	NA	NA	0.78	disease	0.49	neutral	0.63	disease	3	0.72	neutral	0.37	neutral	0	NA	0.65	deleterious	-0.9	medium_impact	-0.07	medium_impact	1.64	medium_impact	0.23	0.8	75.1	11.41	0.35	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9283	9283	T	C	MI.6801	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	77	26	L	P	cTa/cCa	-0.33	0	0	possibly_damaging	0.82	neutral	0.22	neutral	2.42	deleterious	-3.5	deleterious	-3.12	medium_impact	2.81	0.55	damaging	0.34	neutral	3.67	23.30	deleterious	0.02	0.35	NA	NA	0.79	disease	0.51	disease	0.65	disease	3	0.88	neutral	0.2	neutral	0	NA	0.72	deleterious	-1.51	low_impact	-0.12	medium_impact	1.34	medium_impact	0.26	0.8	75.1	11.41	0.34	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9283	9283	T	A	MI.6802	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	77	26	L	Q	cTa/cAa	-0.33	0	0	possibly_damaging	0.67	neutral	0.22	neutral	2.41	deleterious	-3.25	neutral	-2.44	medium_impact	3.15	0.64	neutral	0.35	neutral	3.81	23.40	deleterious	0.04	0.35	NA	NA	0.57	disease	0.34	neutral	0.49	neutral	0	0.81	neutral	0.28	neutral	0	NA	0.62	deleterious	-1.17	low_impact	-0.12	medium_impact	1.64	medium_impact	0.24	0.8	75.1	11.41	0.41	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9285	9285	A	T	MI.6803	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	79	27	M	L	Atg/Ttg	-4.73	0	0	benign	0	neutral	0.99	neutral	2.43	neutral	0.67	neutral	0.59	neutral_impact	-0.93	0.79	neutral	0.96	neutral	-1.39	0.00	neutral	0.26	0.45	NA	NA	0.27	neutral	0.31	neutral	0.2	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.11	neutral	2.05	high_impact	1.33	medium_impact	-2.02	low_impact	0.36	0.8	20.69	18.51	0.25	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9285	9285	A	G	MI.6804	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	79	27	M	V	Atg/Gtg	-4.73	0	0	benign	0.01	neutral	0.62	neutral	2.37	neutral	0.17	neutral	-0.88	low_impact	1.38	0.75	neutral	0.63	neutral	0.64	8.46	deleterious	0.22	0.45	NA	NA	0.6	disease	0.43	neutral	0.48	neutral	0	0.37	neutral	0.81	deleterious	-6	neutral	0.16	neutral	1.07	medium_impact	0.31	medium_impact	0.05	medium_impact	0.41	0.8	20.69	18.51	0.25	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9285	9285	A	C	MI.6805	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	79	27	M	L	Atg/Ctg	-4.73	0	0	benign	0	neutral	0.99	neutral	2.43	neutral	0.67	neutral	0.59	neutral_impact	-0.93	0.79	neutral	0.96	neutral	-1.41	0.00	neutral	0.26	0.45	NA	NA	0.27	neutral	0.31	neutral	0.2	neutral	6	0.01	neutral	1	deleterious	-6	neutral	0.11	neutral	2.05	high_impact	1.33	medium_impact	-2.02	low_impact	0.36	0.8	20.69	18.51	0.25	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9286	9286	T	C	MI.6806	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	80	27	M	T	aTg/aCg	-1.26	0	0	benign	0	neutral	0.87	neutral	2.33	neutral	-0.37	neutral	-1.7	neutral_impact	0.68	0.72	neutral	0.75	neutral	-0.77	0.05	neutral	0.12	0.4	NA	NA	0.39	neutral	0.41	neutral	0.17	neutral	7	0.13	neutral	0.94	deleterious	-6	neutral	0.14	neutral	2.05	high_impact	0.66	medium_impact	-0.57	medium_impact	0.19	0.8	20.69	18.51	0.31	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9286	9286	T	A	MI.6807	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	80	27	M	K	aTg/aAg	-1.26	0	0	benign	0.02	neutral	0.32	neutral	2.26	neutral	-2.15	deleterious	-3.25	medium_impact	2.64	0.65	neutral	0.36	neutral	2.03	16.41	deleterious	0.03	0.35	NA	NA	0.82	disease	0.68	disease	0.78	disease	6	0.67	neutral	0.65	deleterious	-3	neutral	0.23	neutral	0.77	medium_impact	0.01	medium_impact	1.18	medium_impact	0.31	0.8	20.69	18.51	0.3	N	0.83	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9287	9287	G	C	MI.6808	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	81	27	M	I	atG/atC	4.76	0.7	0.01	benign	0.01	neutral	0.48	neutral	2.34	neutral	0.06	neutral	-0.46	neutral_impact	0.76	0.74	neutral	0.75	neutral	0.32	5.84	deleterious	0.27	0.45	NA	NA	0.65	disease	0.38	neutral	0.48	neutral	0	0.51	neutral	0.74	deleterious	-6	neutral	0.18	neutral	1.07	medium_impact	0.17	medium_impact	-0.5	medium_impact	0.35	0.8	20.69	18.51	0.37	N	0.23	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9287	9287	G	T	MI.6809	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	81	27	M	I	atG/atT	4.76	0.7	0.01	benign	0.01	neutral	0.48	neutral	2.34	neutral	0.06	neutral	-0.46	neutral_impact	0.76	0.74	neutral	0.75	neutral	0.48	7.25	deleterious	0.27	0.45	NA	NA	0.65	disease	0.38	neutral	0.48	neutral	0	0.51	neutral	0.74	deleterious	-6	neutral	0.18	neutral	1.07	medium_impact	0.17	medium_impact	-0.5	medium_impact	0.35	0.8	20.69	18.51	0.36	N	0.23	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8846	8846	C	A	MI.681	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	320	107	P	H	cCc/cAc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	4.29	neutral	-1.99	deleterious	-8.5	high_impact	3.92	0.63	neutral	0.11	damaging	4.03	23.60	deleterious	0.3	0.65	0.79	disease	0.89	disease	0.72	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	2.26	high_impact	0.64	0.9	48.67	8.6	0.49	N	0.64	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9288	9288	A	T	MI.6810	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	82	28	T	S	Acc/Tcc	-3.34	0	0	probably_damaging	0.98	neutral	0.47	neutral	2.46	neutral	-1.69	deleterious	-2.96	medium_impact	3.03	0.6	damaging	0.51	neutral	2.82	21.50	deleterious	0.31	0.45	NA	NA	0.63	disease	0.56	disease	0.58	disease	2	0.97	neutral	0.25	neutral	1	deleterious	0.72	deleterious	-2.51	low_impact	0.16	medium_impact	1.53	medium_impact	0.75	0.85	75.48	11.24	0.33	N	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9288	9288	A	C	MI.6811	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	82	28	T	P	Acc/Ccc	-3.34	0	0	probably_damaging	1	neutral	0.2	neutral	2.45	neutral	-2.11	deleterious	-4.6	medium_impact	2.63	0.57	damaging	0.66	neutral	3.23	22.80	deleterious	0.07	0.35	NA	NA	0.87	disease	0.57	disease	0.67	disease	3	1	deleterious	0.1	neutral	1	deleterious	0.82	deleterious	-3.78	low_impact	-0.15	medium_impact	1.17	medium_impact	0.46	0.8	75.48	11.24	0.35	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9288	9288	A	G	MI.6812	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	82	28	T	A	Acc/Gcc	-3.34	0	0	probably_damaging	0.98	neutral	0.51	neutral	2.54	neutral	-0.47	deleterious	-3.42	low_impact	0.84	0.68	neutral	0.81	neutral	1.77	14.83	neutral	0.27	0.45	NA	NA	0.41	neutral	0.37	neutral	0.17	neutral	7	0.97	neutral	0.27	neutral	-2	neutral	0.70	deleterious	-2.51	low_impact	0.2	medium_impact	-0.43	medium_impact	0.46	0.8	75.48	11.24	0.3	N	0.44	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9289	9289	C	A	MI.6813	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	83	28	T	N	aCc/aAc	6.84	1	0	probably_damaging	1	neutral	0.3	neutral	2.44	neutral	-2.49	deleterious	-3.94	medium_impact	3.48	0.64	neutral	0.43	neutral	3.43	23.00	deleterious	0.25	0.45	NA	NA	0.81	disease	0.6	disease	0.7	disease	4	1	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	-0.02	medium_impact	1.94	medium_impact	0.65	0.8	75.48	11.24	0.54	P	0.89	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9289	9289	C	T	MI.6814	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	83	28	T	I	aCc/aTc	6.84	1	0	probably_damaging	1	neutral	0.41	neutral	2.5	neutral	-0.95	deleterious	-4.14	medium_impact	2.52	0.65	neutral	0.53	neutral	3.76	23.30	deleterious	0.13	0.4	NA	NA	0.87	disease	0.57	disease	0.67	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	0.1	medium_impact	1.08	medium_impact	0.70	0.85	75.48	11.24	0.47	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9289	9289	C	G	MI.6815	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	83	28	T	S	aCc/aGc	6.84	1	0	probably_damaging	0.98	neutral	0.47	neutral	2.46	neutral	-1.69	deleterious	-2.96	medium_impact	3.03	0.6	damaging	0.51	neutral	3.02	22.30	deleterious	0.31	0.45	NA	NA	0.63	disease	0.56	disease	0.58	disease	2	0.97	neutral	0.25	neutral	1	deleterious	0.72	deleterious	-2.51	low_impact	0.16	medium_impact	1.53	medium_impact	0.75	0.85	75.48	11.24	0.54	P	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9291	9291	T	G	MI.6816	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	85	29	S	A	Tcc/Gcc	-3.11	0	0	probably_damaging	0.98	neutral	0.53	neutral	2.29	neutral	0.46	neutral	-1.27	low_impact	1.46	0.62	neutral	0.22	damaging	3.46	23.00	deleterious	0.31	0.5	NA	NA	0.53	disease	0.39	neutral	0.45	neutral	1	0.97	neutral	0.28	neutral	-2	neutral	0.66	deleterious	-2.51	low_impact	0.22	medium_impact	0.13	medium_impact	0.61	0.8	75.1	11.48	0.24	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9291	9291	T	C	MI.6817	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	85	29	S	P	Tcc/Ccc	-3.11	0	0	probably_damaging	1	neutral	0.21	neutral	2.21	neutral	-1.97	deleterious	-2.9	medium_impact	3.48	0.58	damaging	0.04	damaging	3.80	23.40	deleterious	0.06	0.35	NA	NA	0.9	disease	0.58	disease	0.76	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.83	deleterious	-3.78	low_impact	-0.14	medium_impact	1.94	medium_impact	0.35	0.8	75.1	11.48	0.28	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9291	9291	T	A	MI.6818	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	85	29	S	T	Tcc/Acc	-3.11	0	0	probably_damaging	0.96	neutral	0.45	neutral	2.29	neutral	0.21	neutral	-0.67	low_impact	1.23	0.7	neutral	0.28	damaging	2.38	18.71	deleterious	0.3	0.45	NA	NA	0.39	neutral	0.28	neutral	0.2	neutral	6	0.96	neutral	0.25	neutral	-2	neutral	0.68	deleterious	-2.21	low_impact	0.14	medium_impact	-0.08	medium_impact	0.68	0.85	75.1	11.48	0.37	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9292	9292	C	G	MI.6819	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	86	29	S	C	tCc/tGc	5.68	1	0	probably_damaging	1	neutral	0.18	neutral	2.21	neutral	-1.87	deleterious	-2.54	medium_impact	2.93	0.62	neutral	0.18	damaging	3.38	22.90	deleterious	0.09	0.35	NA	NA	0.82	disease	0.36	neutral	0.67	disease	3	1	deleterious	0.09	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	-0.18	medium_impact	1.44	medium_impact	0.43	0.8	75.1	11.48	0.47	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8846	8846	C	G	MI.682	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	320	107	P	R	cCc/cGc	5.68	1	0	probably_damaging	1	deleterious	0	neutral	4.3	neutral	-1.46	deleterious	-8.51	high_impact	3.92	0.6	damaging	0.12	damaging	3.59	23.20	deleterious	0.25	0.65	0.43	neutral	0.94	disease	0.76	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.26	high_impact	0.65	0.9	48.67	8.6	0.53	P	0.65	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9292	9292	C	T	MI.6820	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	86	29	S	F	tCc/tTc	5.68	1	0	probably_damaging	1	neutral	0.72	neutral	2.24	neutral	0.62	deleterious	-3.01	low_impact	1.49	0.64	neutral	0.17	damaging	4.02	23.60	deleterious	0.07	0.35	NA	NA	0.8	disease	0.34	neutral	0.51	disease	0	1	deleterious	0.36	neutral	-2	neutral	0.78	deleterious	-3.78	low_impact	0.43	medium_impact	0.15	medium_impact	0.32	0.8	75.1	11.48	0.4	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9292	9292	C	A	MI.6821	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	86	29	S	Y	tCc/tAc	5.68	1	0	probably_damaging	1	neutral	1	neutral	2.22	neutral	-0.2	deleterious	-3.12	low_impact	1.82	0.62	neutral	0.05	damaging	3.84	23.40	deleterious	0.06	0.35	NA	NA	0.87	disease	0.42	neutral	0.75	disease	5	1	deleterious	0.5	deleterious	-2	neutral	0.79	deleterious	-3.78	low_impact	1.9	high_impact	0.45	medium_impact	0.36	0.8	75.1	11.48	0.35	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9294	9294	G	A	MI.6822	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	88	30	G	S	Ggc/Agc	-11.9	0	0	probably_damaging	1	neutral	0.41	neutral	2.29	neutral	-2.61	deleterious	-5.33	low_impact	1.79	0.46	damaging	0.04	damaging	3.98	23.60	deleterious	0.08	0.35	NA	NA	0.59	disease	0.47	neutral	0.44	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.78	deleterious	-3.78	low_impact	0.1	medium_impact	0.42	medium_impact	0.63	0.8	74.71	11.6	0.29	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	COSM1155700	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9294	9294	G	T	MI.6823	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	88	30	G	C	Ggc/Tgc	-11.9	0	0	probably_damaging	1	neutral	0.18	neutral	2.11	deleterious	-5.52	deleterious	-8	high_impact	3.83	0.54	damaging	0.02	damaging	3.94	23.50	deleterious	0.04	0.35	NA	NA	0.87	disease	0.69	disease	0.75	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.18	medium_impact	2.25	high_impact	0.28	0.8	74.71	11.6	0.31	N	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9294	9294	G	C	MI.6824	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	88	30	G	R	Ggc/Cgc	-11.9	0	0	probably_damaging	1	neutral	0.35	neutral	2.15	deleterious	-4.93	deleterious	-7.11	high_impact	4.38	0.62	neutral	0.02	damaging	3.78	23.40	deleterious	0.03	0.35	NA	NA	0.87	disease	0.79	disease	0.81	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	0.04	medium_impact	2.74	high_impact	0.33	0.8	74.71	11.6	0.43	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9295	9295	G	C	MI.6825	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	89	30	G	A	gGc/gCc	6.14	1	0	probably_damaging	1	neutral	0.51	neutral	2.19	neutral	-2.59	deleterious	-5.33	medium_impact	3.23	0.46	damaging	0.01	damaging	2.93	22.00	deleterious	0.09	0.35	NA	NA	0.59	disease	0.6	disease	0.56	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	0.2	medium_impact	1.71	medium_impact	0.38	0.8	74.71	11.6	0.47	N	0.30	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9295	9295	G	T	MI.6826	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	89	30	G	V	gGc/gTc	6.14	1	0	probably_damaging	1	neutral	0.52	neutral	2.13	deleterious	-4.19	deleterious	-7.99	high_impact	4.03	0.52	damaging	0.01	damaging	3.59	23.20	deleterious	0.03	0.35	NA	NA	0.82	disease	0.69	disease	0.72	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.21	medium_impact	2.43	high_impact	0.19	0.8	74.71	11.6	0.49	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9295	9295	G	A	MI.6827	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	89	30	G	D	gGc/gAc	6.14	1	0	probably_damaging	1	neutral	0.21	neutral	2.18	deleterious	-5.01	deleterious	-6.22	high_impact	4.38	0.48	damaging	0.02	damaging	3.62	23.20	deleterious	0.03	0.35	NA	NA	0.87	disease	0.78	disease	0.8	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.14	medium_impact	2.74	high_impact	0.16	0.8	74.71	11.6	0.59	P	0.98	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9297	9297	C	A	MI.6828	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	91	31	L	M	Cta/Ata	-10.75	0	0	probably_damaging	0.99	neutral	0.21	neutral	2.37	neutral	-1.94	neutral	-0.99	low_impact	1.38	0.74	neutral	0.77	neutral	2.37	18.62	deleterious	0.26	0.45	NA	NA	0.27	neutral	0.25	neutral	0.21	neutral	6	1	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-2.81	low_impact	-0.14	medium_impact	0.05	medium_impact	0.59	0.8	76.25	10.27	0.49	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9297	9297	C	G	MI.6829	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	91	31	L	V	Cta/Gta	-10.75	0	0	probably_damaging	0.91	neutral	0.56	neutral	2.41	neutral	-0.65	neutral	-1.95	medium_impact	2.19	0.62	neutral	0.53	neutral	3.23	22.80	deleterious	0.22	0.45	NA	NA	0.55	disease	0.42	neutral	0.48	neutral	0	0.9	neutral	0.33	neutral	1	deleterious	0.68	deleterious	-1.85	low_impact	0.25	medium_impact	0.78	medium_impact	0.57	0.8	76.25	10.27	0.32	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8848	8848	T	A	MI.683	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	322	108	L	M	Tta/Ata	-10.51	0	0	probably_damaging	1	neutral	0.15	neutral	4.19	neutral	-2.43	neutral	-1.83	low_impact	1.48	0.85	neutral	0.74	neutral	2.48	19.36	deleterious	0.4	0.65	0.72	disease	0.48	neutral	0.36	neutral	0.52	disease	0	1	deleterious	0.08	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	-0.13	medium_impact	0.17	medium_impact	0.73	0.9	47.79	8.45	0.41	N	0.96	disease_causing	0.53	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9298	9298	T	G	MI.6830	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	92	31	L	R	cTa/cGa	-1.49	0	0	probably_damaging	0.99	neutral	0.33	neutral	2.35	neutral	-2.44	deleterious	-4.54	medium_impact	3.5	0.59	damaging	0.29	neutral	3.99	23.60	deleterious	0.03	0.35	NA	NA	0.89	disease	0.59	disease	0.74	disease	5	0.99	deleterious	0.17	neutral	1	deleterious	0.85	deleterious	-2.81	low_impact	0.02	medium_impact	1.95	medium_impact	0.24	0.8	76.25	10.27	0.33	N	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9298	9298	T	C	MI.6831	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	92	31	L	P	cTa/cCa	-1.49	0	0	probably_damaging	1	neutral	0.19	neutral	2.33	deleterious	-3.34	deleterious	-5.31	high_impact	3.85	0.52	damaging	0.34	neutral	3.72	23.30	deleterious	0.03	0.35	NA	NA	0.85	disease	0.67	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.17	medium_impact	2.27	high_impact	0.32	0.8	76.25	10.27	0.37	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9298	9298	T	A	MI.6832	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	92	31	L	Q	cTa/cAa	-1.49	0	0	probably_damaging	0.99	neutral	0.31	neutral	2.33	neutral	-2.45	deleterious	-4.42	high_impact	3.85	0.61	neutral	0.37	neutral	3.88	23.50	deleterious	0.05	0.35	NA	NA	0.77	disease	0.44	neutral	0.59	disease	2	0.99	deleterious	0.16	neutral	2	deleterious	0.77	deleterious	-2.81	low_impact	-0.01	medium_impact	2.27	high_impact	0.30	0.8	76.25	10.27	0.41	N	0.79	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9300	9300	G	T	MI.6833	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	94	32	A	S	Gcc/Tcc	-1.03	0	0.02	benign	0.05	neutral	0.23	neutral	2.26	neutral	-0.94	neutral	-1.57	medium_impact	2.33	0.65	neutral	0.71	neutral	1.62	13.99	neutral	0.19	0.45	0.1	neutral	0.52	disease	0.54	disease	0.49	neutral	0	0.75	neutral	0.59	deleterious	-3	neutral	0.13	neutral	0.37	medium_impact	-0.11	medium_impact	0.91	medium_impact	0.54	0.8	17.62	14.59	0.43	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9300	9300	G	C	MI.6834	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	94	32	A	P	Gcc/Ccc	-1.03	0	0.02	benign	0.21	neutral	0.08	neutral	2.21	neutral	-2.59	deleterious	-2.62	medium_impact	3.19	0.55	damaging	0.32	neutral	3.24	22.80	deleterious	0.03	0.35	0.31	neutral	0.85	disease	0.7	disease	0.79	disease	6	0.91	neutral	0.44	neutral	-3	neutral	0.39	neutral	-0.31	medium_impact	-0.41	medium_impact	1.68	medium_impact	0.64	0.8	17.62	14.59	0.34	N	0.22	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9300	9300	G	A	MI.6835	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	94	32	A	T	Gcc/Acc	-1.03	0	0.02	benign	0	neutral	0.38	neutral	2.3	neutral	-0.29	neutral	-1.07	medium_impact	2	0.81	neutral	0.95	neutral	0.84	9.73	deleterious	0.15	0.4	0.12	neutral	0.43	neutral	0.34	neutral	0.44	neutral	1	0.62	neutral	0.69	deleterious	-3	neutral	0.11	neutral	2.05	high_impact	0.07	medium_impact	0.61	medium_impact	0.82	0.85	17.62	14.59	0.41	N	0.00	polymorphism	1	0.02	rs371745772	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9301	9301	C	T	MI.6836	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	95	32	A	V	gCc/gTc	-0.33	0	0	benign	0	neutral	0.37	neutral	2.58	neutral	1.71	neutral	0.5	neutral_impact	0.12	0.68	neutral	0.73	neutral	0.40	6.65	deleterious	0.14	0.4	0.09	neutral	0.2	neutral	0.27	neutral	0.33	neutral	3	0.63	neutral	0.69	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	0.06	medium_impact	-1.08	low_impact	0.80	0.85	17.62	14.59	0.48	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9301	9301	C	G	MI.6837	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	95	32	A	G	gCc/gGc	-0.33	0	0	benign	0.07	neutral	0.45	neutral	2.24	neutral	-1.47	deleterious	-2.57	low_impact	1.42	0.64	neutral	0.62	neutral	1.88	15.49	deleterious	0.15	0.45	0.18	neutral	0.58	disease	0.46	neutral	0.47	neutral	1	0.5	neutral	0.69	deleterious	-6	neutral	0.17	neutral	0.22	medium_impact	0.14	medium_impact	0.09	medium_impact	0.61	0.8	17.62	14.59	0.36	N	0.27	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9301	9301	C	A	MI.6838	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	95	32	A	D	gCc/gAc	-0.33	0	0	benign	0.16	neutral	0.08	neutral	2.22	neutral	-2.39	deleterious	-3.11	high_impact	3.53	0.55	damaging	0.37	neutral	2.76	21.10	deleterious	0.02	0.35	0.22	neutral	0.85	disease	0.69	disease	0.79	disease	6	0.91	neutral	0.46	neutral	-2	neutral	0.28	neutral	-0.17	medium_impact	-0.41	medium_impact	1.98	medium_impact	0.49	0.8	17.62	14.59	0.38	N	0.25	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9303	9303	A	G	MI.6839	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	97	33	M	V	Atg/Gtg	-16.07	0	0	benign	0	neutral	0.56	neutral	2.35	neutral	0.24	neutral	-1.06	low_impact	0.92	0.67	neutral	0.28	damaging	-0.65	0.10	neutral	0.26	0.45	0.14	neutral	0.58	disease	0.44	neutral	0.43	neutral	1	0.44	neutral	0.78	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	0.25	medium_impact	-0.36	medium_impact	0.48	0.8	76.25	10.49	0.27	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8848	8848	T	G	MI.684	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	322	108	L	V	Tta/Gta	-10.51	0	0	probably_damaging	0.99	deleterious	0.03	neutral	4.38	neutral	0.57	deleterious	-2.79	medium_impact	2.17	0.55	damaging	0.5	neutral	3.40	23.00	deleterious	0.35	0.65	0.31	neutral	0.73	disease	0.6	disease	0.59	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.71	deleterious	-2.65	low_impact	-0.56	medium_impact	0.76	medium_impact	0.56	0.9	47.79	8.45	0.37	N	0.87	disease_causing	0.59	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9303	9303	A	C	MI.6840	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	97	33	M	L	Atg/Ctg	-16.07	0	0	benign	0.01	neutral	1	neutral	2.51	neutral	1.36	neutral	-0.4	neutral_impact	-0.02	0.63	neutral	0.26	damaging	-0.26	0.82	neutral	0.23	0.45	0.12	neutral	0.51	disease	0.3	neutral	0.42	neutral	2	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.07	medium_impact	1.9	high_impact	-1.2	low_impact	0.40	0.8	76.25	10.49	0.27	N	0.95	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9303	9303	A	T	MI.6841	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	97	33	M	L	Atg/Ttg	-16.07	0	0	benign	0.01	neutral	1	neutral	2.51	neutral	1.36	neutral	-0.4	neutral_impact	-0.02	0.63	neutral	0.26	damaging	-0.20	1.10	neutral	0.23	0.45	0.12	neutral	0.51	disease	0.3	neutral	0.42	neutral	2	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.07	medium_impact	1.9	high_impact	-1.2	low_impact	0.40	0.8	76.25	10.49	0.27	N	0.95	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9304	9304	T	C	MI.6842	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	98	33	M	T	aTg/aCg	4.06	0.98	0	benign	0.1	neutral	0.26	neutral	2.27	neutral	-0.74	neutral	-1.62	low_impact	1.09	0.64	neutral	0.25	damaging	-0.19	1.14	neutral	0.13	0.4	0.14	neutral	0.61	disease	0.46	neutral	0.44	neutral	1	0.71	neutral	0.58	deleterious	-6	neutral	0.19	neutral	0.06	medium_impact	-0.07	medium_impact	-0.21	medium_impact	0.19	0.8	76.25	10.49	0.51	N	0.99	polymorphism	1	0.03	.	.	.	.	.	.	COSM1155702	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9304	9304	T	A	MI.6843	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	98	33	M	K	aTg/aAg	4.06	0.98	0	benign	0.12	neutral	0.46	neutral	2.25	neutral	-1.07	neutral	-1.09	low_impact	0.82	0.62	neutral	0.14	damaging	0.55	7.78	deleterious	0.04	0.35	0.16	neutral	0.62	disease	0.44	neutral	0.43	neutral	1	0.46	neutral	0.67	deleterious	-6	neutral	0.23	neutral	-0.03	medium_impact	0.15	medium_impact	-0.45	medium_impact	0.30	0.8	76.25	10.49	0.45	N	0.99	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9305	9305	G	T	MI.6844	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	99	33	M	I	atG/atT	2.44	0.98	0	benign	0.01	neutral	0.52	neutral	2.33	neutral	0.09	neutral	-1.1	neutral_impact	0.6	0.68	neutral	0.34	neutral	-0.04	2.26	deleterious	0.21	0.45	0.15	neutral	0.69	disease	0.44	neutral	0.49	neutral	0	0.46	neutral	0.76	deleterious	-6	neutral	0.16	neutral	1.07	medium_impact	0.21	medium_impact	-0.65	medium_impact	0.52	0.8	76.25	10.49	0.42	N	0.95	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9305	9305	G	C	MI.6845	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	99	33	M	I	atG/atC	2.44	0.98	0	benign	0.01	neutral	0.52	neutral	2.33	neutral	0.09	neutral	-1.1	neutral_impact	0.6	0.68	neutral	0.34	neutral	-0.17	1.29	neutral	0.21	0.45	0.15	neutral	0.69	disease	0.44	neutral	0.49	neutral	0	0.46	neutral	0.76	deleterious	-6	neutral	0.16	neutral	1.07	medium_impact	0.21	medium_impact	-0.65	medium_impact	0.52	0.8	76.25	10.49	0.42	N	0.95	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9306	9306	T	C	MI.6846	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	100	34	W	R	Tga/Cga	-0.8	0.02	0	probably_damaging	1	neutral	0.42	neutral	2.48	neutral	-1.51	deleterious	-11.88	high_impact	4.08	0.69	neutral	0.03	damaging	3.38	22.90	deleterious	0.04	0.35	0.15	neutral	0.87	disease	0.76	disease	0.76	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	0.11	medium_impact	2.47	high_impact	0.27	0.8	74.71	11.48	0.41	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9306	9306	T	G	MI.6847	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	100	34	W	G	Tga/Gga	-0.8	0.02	0	probably_damaging	1	neutral	0.3	neutral	2.46	neutral	-1.94	deleterious	-10.98	high_impact	3.53	0.63	neutral	0.04	damaging	3.70	23.30	deleterious	0.07	0.35	0.2	neutral	0.75	disease	0.72	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.71	deleterious	-3.78	low_impact	-0.02	medium_impact	1.98	medium_impact	0.22	0.8	74.71	11.48	0.31	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9307	9307	G	C	MI.6848	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	101	34	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	neutral	0.41	neutral	2.49	neutral	-1.33	deleterious	-11.84	medium_impact	2.69	0.62	neutral	0.03	damaging	3.89	23.50	deleterious	0.07	0.35	0.12	neutral	0.75	disease	0.7	disease	0.55	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	0.1	medium_impact	1.23	medium_impact	0.24	0.8	74.71	11.48	0.37	N	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9307	9307	G	T	MI.6849	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	101	34	W	L	tGa/tTa	7.53	1	0	probably_damaging	1	neutral	0.75	neutral	2.6	neutral	0.1	deleterious	-10.94	medium_impact	2.26	0.58	damaging	0.04	damaging	4.13	23.80	deleterious	0.1	0.4	0.09	neutral	0.73	disease	0.59	disease	0.52	disease	0	1	deleterious	0.38	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	0.46	medium_impact	0.84	medium_impact	0.18	0.8	74.71	11.48	0.35	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8849	8849	T	C	MI.685	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	323	108	L	S	tTa/tCa	-0.8	0	0	probably_damaging	1	deleterious	0.01	neutral	4.19	neutral	-0.66	deleterious	-5.58	medium_impact	2.81	0.65	neutral	0.55	neutral	3.73	23.30	deleterious	0.22	0.65	0.58	disease	0.84	disease	0.6	disease	0.69	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.6	low_impact	-0.84	medium_impact	1.31	medium_impact	0.66	0.9	47.79	8.45	0.29	N	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9308	9308	A	C	MI.6850	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	102	34	W	C	tgA/tgC	9.38	1	0	probably_damaging	1	neutral	0.21	neutral	2.44	deleterious	-3.22	deleterious	-11.03	high_impact	4.08	0.65	neutral	0.03	damaging	3.86	23.50	deleterious	0.06	0.35	0.33	neutral	0.84	disease	0.7	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.73	deleterious	-3.78	low_impact	-0.14	medium_impact	2.47	high_impact	0.20	0.8	74.71	11.48	0.48	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9308	9308	A	T	MI.6851	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	102	34	W	C	tgA/tgT	9.38	1	0	probably_damaging	1	neutral	0.21	neutral	2.44	deleterious	-3.22	deleterious	-11.03	high_impact	4.08	0.65	neutral	0.03	damaging	3.92	23.50	deleterious	0.06	0.35	0.33	neutral	0.84	disease	0.7	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.73	deleterious	-3.78	low_impact	-0.14	medium_impact	2.47	high_impact	0.20	0.8	74.71	11.48	0.49	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9309	9309	T	G	MI.6852	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	103	35	F	V	Ttt/Gtt	2.67	1	0	probably_damaging	1	neutral	0.51	neutral	2.24	neutral	-0.66	deleterious	-5.56	low_impact	1.66	0.7	neutral	0.56	neutral	3.81	23.40	deleterious	0.09	0.4	0.15	neutral	0.84	disease	0.69	disease	0.68	disease	4	1	deleterious	0.26	neutral	-2	neutral	0.69	deleterious	-3.78	low_impact	0.2	medium_impact	0.31	medium_impact	0.34	0.8	73.95	11.58	0.38	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9309	9309	T	A	MI.6853	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	103	35	F	I	Ttt/Att	2.67	1	0	probably_damaging	0.99	neutral	0.37	neutral	2.3	neutral	-0.17	deleterious	-4.75	low_impact	1.52	0.61	neutral	0.82	neutral	2.70	20.80	deleterious	0.13	0.4	0.18	neutral	0.85	disease	0.48	neutral	0.52	disease	0	0.99	deleterious	0.19	neutral	-2	neutral	0.71	deleterious	-2.81	low_impact	0.06	medium_impact	0.18	medium_impact	0.50	0.8	73.95	11.58	0.44	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9309	9309	T	C	MI.6854	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	103	35	F	L	Ttt/Ctt	2.67	1	0	probably_damaging	0.98	neutral	0.59	neutral	2.53	neutral	1.05	deleterious	-4.67	low_impact	1.47	0.54	damaging	0.8	neutral	2.09	16.80	deleterious	0.18	0.45	0.14	neutral	0.74	disease	0.58	disease	0.53	disease	1	0.98	deleterious	0.31	neutral	-2	neutral	0.68	deleterious	-2.51	low_impact	0.28	medium_impact	0.14	medium_impact	0.69	0.85	73.95	11.58	0.42	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9310	9310	T	A	MI.6855	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	104	35	F	Y	tTt/tAt	4.52	1	0	probably_damaging	0.98	neutral	1	neutral	2.13	neutral	-2.86	neutral	-2.5	high_impact	3.5	0.8	neutral	0.44	neutral	4.16	23.80	deleterious	0.14	0.4	0.28	neutral	0.76	disease	0.67	disease	0.69	disease	4	0.98	deleterious	0.51	deleterious	2	deleterious	0.71	deleterious	-2.51	low_impact	1.9	high_impact	1.95	medium_impact	0.68	0.85	73.95	11.58	0.45	N	0.80	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9310	9310	T	C	MI.6856	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	104	35	F	S	tTt/tCt	4.52	1	0	probably_damaging	1	neutral	0.42	neutral	2.14	neutral	-2.73	deleterious	-6.51	high_impact	3.5	0.91	neutral	0.61	neutral	4.13	23.80	deleterious	0.04	0.35	0.1	neutral	0.8	disease	0.66	disease	0.69	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.66	deleterious	-3.78	low_impact	0.11	medium_impact	1.95	medium_impact	0.34	0.8	73.95	11.58	0.48	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9310	9310	T	G	MI.6857	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	104	35	F	C	tTt/tGt	4.52	1	0	probably_damaging	1	neutral	0.15	neutral	2.12	deleterious	-3.91	deleterious	-6.53	high_impact	3.5	0.76	neutral	0.47	neutral	4.01	23.60	deleterious	0.04	0.35	0.43	neutral	0.86	disease	0.69	disease	0.74	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.73	deleterious	-3.78	low_impact	-0.24	medium_impact	1.95	medium_impact	0.20	0.8	73.95	11.58	0.47	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9311	9311	T	G	MI.6858	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	105	35	F	L	ttT/ttG	7.53	1	0	probably_damaging	0.98	neutral	0.59	neutral	2.53	neutral	1.05	deleterious	-4.67	low_impact	1.47	0.54	damaging	0.8	neutral	2.31	18.24	deleterious	0.18	0.45	0.14	neutral	0.74	disease	0.58	disease	0.53	disease	1	0.98	deleterious	0.31	neutral	-2	neutral	0.68	deleterious	-2.51	low_impact	0.28	medium_impact	0.14	medium_impact	0.69	0.85	73.95	11.58	0.51	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9311	9311	T	A	MI.6859	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	105	35	F	L	ttT/ttA	7.53	1	0	probably_damaging	0.98	neutral	0.59	neutral	2.53	neutral	1.05	deleterious	-4.67	low_impact	1.47	0.54	damaging	0.8	neutral	2.38	18.68	deleterious	0.18	0.45	0.14	neutral	0.74	disease	0.58	disease	0.53	disease	1	0.98	deleterious	0.31	neutral	-2	neutral	0.68	deleterious	-2.51	low_impact	0.28	medium_impact	0.14	medium_impact	0.69	0.85	73.95	11.58	0.52	P	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8849	8849	T	G	MI.686	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	323	108	L	W	tTa/tGa	-0.8	0	0	probably_damaging	1	deleterious	0	neutral	4.12	deleterious	-4.85	deleterious	-5.52	medium_impact	3.15	0.74	neutral	0.49	neutral	3.76	23.30	deleterious	0.14	0.65	0.92	disease	0.84	disease	0.62	disease	0.71	disease	4	1	deleterious	0	neutral	5	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	1.6	medium_impact	0.58	0.9	47.79	8.45	0.29	N	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9312	9312	C	A	MI.6860	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	106	36	H	N	Cac/Aac	-4.96	0	0	probably_damaging	0.98	neutral	0.29	neutral	2.15	neutral	-1.87	deleterious	-5.89	low_impact	1.56	0.56	damaging	0.44	neutral	1.78	14.88	neutral	0.3	0.45	0.44	neutral	0.6	disease	0.53	disease	0.45	neutral	1	0.98	deleterious	0.16	neutral	-2	neutral	0.72	deleterious	-2.51	low_impact	-0.03	medium_impact	0.22	medium_impact	0.35	0.8	73.95	11.55	0.32	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9312	9312	C	T	MI.6861	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	106	36	H	Y	Cac/Tac	-4.96	0	0	probably_damaging	0.97	neutral	0.74	neutral	2.13	neutral	-2.49	deleterious	-5.16	medium_impact	2.8	0.63	neutral	0.27	damaging	3.42	23.00	deleterious	0.17	0.45	0.1	neutral	0.72	disease	0.65	disease	0.52	disease	0	0.96	neutral	0.39	neutral	1	deleterious	0.70	deleterious	-2.34	low_impact	0.45	medium_impact	1.33	medium_impact	0.15	0.8	73.95	11.55	0.21	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9312	9312	C	G	MI.6862	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	106	36	H	D	Cac/Gac	-4.96	0	0	probably_damaging	0.98	neutral	0.2	neutral	2.15	neutral	-1.95	deleterious	-7.63	high_impact	3.87	0.68	neutral	0.28	damaging	3.35	22.90	deleterious	0.05	0.35	0.52	disease	0.78	disease	0.8	disease	0.77	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.75	deleterious	-2.51	low_impact	-0.15	medium_impact	2.29	high_impact	0.34	0.8	73.95	11.55	0.42	N	0.98	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9313	9313	A	G	MI.6863	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	107	36	H	R	cAc/cGc	4.52	1	0	probably_damaging	0.97	neutral	0.24	neutral	2.21	neutral	-0.95	deleterious	-6.78	medium_impact	2.77	0.56	damaging	0.52	neutral	1.24	11.97	neutral	0.09	0.4	0.43	neutral	0.8	disease	0.69	disease	0.57	disease	1	0.98	neutral	0.14	neutral	1	deleterious	0.78	deleterious	-2.34	low_impact	-0.09	medium_impact	1.3	medium_impact	0.24	0.8	73.95	11.55	0.42	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9313	9313	A	C	MI.6864	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	107	36	H	P	cAc/cCc	4.52	1	0	probably_damaging	0.99	neutral	0.14	neutral	2.11	deleterious	-3.15	deleterious	-8.38	high_impact	3.87	0.59	damaging	0.32	neutral	2.99	22.20	deleterious	0.03	0.35	0.57	disease	0.83	disease	0.82	disease	0.81	disease	6	1	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-2.81	low_impact	-0.26	medium_impact	2.29	high_impact	0.13	0.8	73.95	11.55	0.55	P	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9313	9313	A	T	MI.6865	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	107	36	H	L	cAc/cTc	4.52	1	0	probably_damaging	0.97	neutral	0.64	neutral	2.15	neutral	-2	deleterious	-9.4	medium_impact	2.93	0.66	neutral	0.34	neutral	3.33	22.90	deleterious	0.05	0.35	0.23	neutral	0.83	disease	0.72	disease	0.74	disease	5	0.96	neutral	0.34	neutral	1	deleterious	0.73	deleterious	-2.34	low_impact	0.33	medium_impact	1.44	medium_impact	0.07	0.8	73.95	11.55	0.42	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9314	9314	C	A	MI.6866	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	108	36	H	Q	caC/caA	6.84	1	0	probably_damaging	0.98	neutral	0.22	neutral	2.18	neutral	-1.34	deleterious	-6.67	medium_impact	2.58	0.58	damaging	0.35	neutral	3.47	23.00	deleterious	0.15	0.4	0.43	neutral	0.68	disease	0.65	disease	0.61	disease	2	0.99	deleterious	0.12	neutral	1	deleterious	0.74	deleterious	-2.51	low_impact	-0.12	medium_impact	1.13	medium_impact	0.31	0.8	73.95	11.55	0.49	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9314	9314	C	G	MI.6867	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	108	36	H	Q	caC/caG	6.84	1	0	probably_damaging	0.98	neutral	0.22	neutral	2.18	neutral	-1.34	deleterious	-6.67	medium_impact	2.58	0.58	damaging	0.35	neutral	3.19	22.70	deleterious	0.15	0.4	0.43	neutral	0.68	disease	0.65	disease	0.61	disease	2	0.99	deleterious	0.12	neutral	1	deleterious	0.74	deleterious	-2.51	low_impact	-0.12	medium_impact	1.13	medium_impact	0.31	0.8	73.95	11.55	0.48	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9315	9315	T	A	MI.6868	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	109	37	F	I	Ttc/Atc	-0.33	0.06	0	benign	0.01	neutral	0.38	neutral	2.59	neutral	0.07	neutral	-0.89	low_impact	1.69	0.71	neutral	0.57	neutral	1.31	12.34	neutral	0.11	0.4	0.15	neutral	0.67	disease	0.34	neutral	0.52	disease	0	0.61	neutral	0.69	deleterious	-6	neutral	0.16	neutral	1.07	medium_impact	0.07	medium_impact	0.33	medium_impact	0.42	0.8	70.88	10.44	0.4	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9315	9315	T	G	MI.6869	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	109	37	F	V	Ttc/Gtc	-0.33	0.06	0	benign	0.04	neutral	0.54	neutral	2.6	neutral	0.3	neutral	-0.57	low_impact	1.06	0.69	neutral	0.5	neutral	0.91	10.14	neutral	0.12	0.4	0.14	neutral	0.65	disease	0.34	neutral	0.5	disease	0	0.42	neutral	0.75	deleterious	-6	neutral	0.15	neutral	0.47	medium_impact	0.23	medium_impact	-0.23	medium_impact	0.30	0.8	70.88	10.44	0.3	N	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8850	8850	A	C	MI.687	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	324	108	L	F	ttA/ttC	5.91	0.9	0	probably_damaging	1	neutral	0.15	neutral	4.15	neutral	-2.56	deleterious	-3.57	low_impact	1.52	0.67	neutral	0.57	neutral	2.47	19.25	deleterious	0.39	0.65	0.73	disease	0.67	disease	0.42	neutral	0.4	neutral	2	1	deleterious	0.08	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	-0.13	medium_impact	0.21	medium_impact	0.64	0.9	47.79	8.45	0.46	N	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9315	9315	T	C	MI.6870	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	109	37	F	L	Ttc/Ctc	-0.33	0.06	0	benign	0	neutral	0.65	neutral	2.67	neutral	0.98	neutral	-0.48	low_impact	0.88	0.77	neutral	0.72	neutral	0.58	8.00	deleterious	0.18	0.45	0.13	neutral	0.51	disease	0.32	neutral	0.41	neutral	2	0.35	neutral	0.83	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	0.35	medium_impact	-0.39	medium_impact	0.44	0.8	70.88	10.44	0.27	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9316	9316	T	G	MI.6871	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	110	37	F	C	tTc/tGc	3.6	0.51	0	possibly_damaging	0.56	neutral	0.16	neutral	2.52	neutral	-2.03	neutral	-1.32	low_impact	1.69	0.67	neutral	0.54	neutral	2.70	20.80	deleterious	0.06	0.35	0.43	neutral	0.77	disease	0.25	neutral	0.59	disease	2	0.83	neutral	0.3	neutral	-3	neutral	0.59	deleterious	-0.97	medium_impact	-0.22	medium_impact	0.33	medium_impact	0.18	0.8	70.88	10.44	0.39	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9316	9316	T	C	MI.6872	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	110	37	F	S	tTc/tCc	3.6	0.51	0	benign	0.21	neutral	0.52	neutral	2.59	neutral	0.13	neutral	0.42	neutral_impact	-0.08	0.76	neutral	0.74	neutral	0.86	9.82	deleterious	0.06	0.35	0.15	neutral	0.51	disease	0.28	neutral	0.41	neutral	2	0.37	neutral	0.66	deleterious	-6	neutral	0.32	neutral	-0.31	medium_impact	0.21	medium_impact	-1.25	low_impact	0.16	0.8	70.88	10.44	0.31	N	0.93	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9316	9316	T	A	MI.6873	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	110	37	F	Y	tTc/tAc	3.6	0.51	0	benign	0.04	neutral	1	neutral	2.59	neutral	0.02	neutral	0.25	neutral_impact	0.19	0.79	neutral	0.94	neutral	0.27	5.39	deleterious	0.18	0.45	0.2	neutral	0.37	neutral	0.16	neutral	0.44	neutral	1	0.04	neutral	0.98	deleterious	-6	neutral	0.19	neutral	0.47	medium_impact	1.9	high_impact	-1.01	low_impact	0.51	0.8	70.88	10.44	0.33	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9317	9317	C	A	MI.6874	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	111	37	F	L	ttC/ttA	-0.1	0	0	benign	0	neutral	0.65	neutral	2.67	neutral	0.98	neutral	-0.48	low_impact	0.88	0.77	neutral	0.72	neutral	1.07	11.03	neutral	0.18	0.45	0.13	neutral	0.51	disease	0.32	neutral	0.41	neutral	2	0.35	neutral	0.83	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	0.35	medium_impact	-0.39	medium_impact	0.44	0.8	70.88	10.44	0.28	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9317	9317	C	G	MI.6875	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	111	37	F	L	ttC/ttG	-0.1	0	0	benign	0	neutral	0.65	neutral	2.67	neutral	0.98	neutral	-0.48	low_impact	0.88	0.77	neutral	0.72	neutral	0.78	9.35	deleterious	0.18	0.45	0.13	neutral	0.51	disease	0.32	neutral	0.41	neutral	2	0.35	neutral	0.83	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	0.35	medium_impact	-0.39	medium_impact	0.44	0.8	70.88	10.44	0.28	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9318	9318	C	A	MI.6876	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	112	38	H	N	Cac/Aac	-3.57	0	0	benign	0.26	neutral	0.4	neutral	2.35	neutral	0.94	neutral	-0.01	neutral_impact	-0.48	0.81	neutral	0.99	neutral	0.67	8.64	deleterious	0.32	0.5	0.08	neutral	0.2	neutral	0.34	neutral	0.34	neutral	3	0.52	neutral	0.57	deleterious	-6	neutral	0.26	neutral	-0.43	medium_impact	0.09	medium_impact	-1.61	low_impact	0.46	0.8	20.69	59.98	0.31	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9318	9318	C	T	MI.6877	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	112	38	H	Y	Cac/Tac	-3.57	0	0	benign	0	neutral	1	neutral	2.41	neutral	2	neutral	-1.02	neutral_impact	-0.32	0.81	neutral	0.91	neutral	-0.13	1.50	neutral	0.21	0.45	0.26	neutral	0.31	neutral	0.22	neutral	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.14	neutral	2.05	high_impact	1.9	high_impact	-1.47	low_impact	0.32	0.8	20.69	59.98	0.33	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9318	9318	C	G	MI.6878	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	112	38	H	D	Cac/Gac	-3.57	0	0	benign	0.26	neutral	0.2	neutral	2.34	neutral	0.52	neutral	-1.89	neutral_impact	0.78	0.71	neutral	0.65	neutral	2.30	18.16	deleterious	0.06	0.35	0.14	neutral	0.6	disease	0.55	disease	0.63	disease	3	0.76	neutral	0.47	deleterious	-6	neutral	0.29	neutral	-0.43	medium_impact	-0.15	medium_impact	-0.48	medium_impact	0.59	0.8	20.69	59.98	0.37	N	0.13	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9319	9319	A	G	MI.6879	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	113	38	H	R	cAc/cGc	0.13	0	0	benign	0.2	neutral	0.34	neutral	2.35	neutral	0.88	neutral	-1.61	low_impact	1.24	0.65	neutral	0.61	neutral	1.35	12.53	neutral	0.15	0.45	0.14	neutral	0.63	disease	0.44	neutral	0.5	disease	0	0.59	neutral	0.57	deleterious	-6	neutral	0.30	neutral	-0.28	medium_impact	0.03	medium_impact	-0.07	medium_impact	0.26	0.8	20.69	59.98	0.37	N	0.11	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8850	8850	A	T	MI.688	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	324	108	L	F	ttA/ttT	5.91	0.9	0	probably_damaging	1	neutral	0.15	neutral	4.15	neutral	-2.56	deleterious	-3.57	low_impact	1.52	0.67	neutral	0.57	neutral	2.48	19.34	deleterious	0.39	0.65	0.73	disease	0.67	disease	0.42	neutral	0.4	neutral	2	1	deleterious	0.08	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	-0.13	medium_impact	0.21	medium_impact	0.64	0.9	47.79	8.45	0.47	P	0.97	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9319	9319	A	C	MI.6880	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	113	38	H	P	cAc/cCc	0.13	0	0	possibly_damaging	0.47	neutral	0.2	neutral	2.32	neutral	-0.19	deleterious	-2.72	low_impact	1.04	0.62	neutral	0.32	neutral	2.88	21.80	deleterious	0.07	0.35	0.28	neutral	0.8	disease	0.52	disease	0.74	disease	5	0.78	neutral	0.37	neutral	-3	neutral	0.59	deleterious	-0.82	medium_impact	-0.15	medium_impact	-0.25	medium_impact	0.29	0.8	20.69	59.98	0.29	N	0.51	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9319	9319	A	T	MI.6881	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	113	38	H	L	cAc/cTc	0.13	0	0	benign	0.08	neutral	0.65	neutral	2.41	neutral	1.93	deleterious	-2.68	neutral_impact	-0.19	0.75	neutral	0.62	neutral	0.79	9.38	deleterious	0.08	0.35	0.19	neutral	0.6	disease	0.44	neutral	0.4	neutral	2	0.26	neutral	0.79	deleterious	-6	neutral	0.18	neutral	0.16	medium_impact	0.35	medium_impact	-1.35	low_impact	0.18	0.8	20.69	59.98	0.28	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9320	9320	C	A	MI.6882	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	114	38	H	Q	caC/caA	2.67	0.02	0	benign	0.38	neutral	0.33	neutral	2.35	neutral	0.95	neutral	-1.52	neutral_impact	0.24	0.76	neutral	0.81	neutral	2.22	17.65	deleterious	0.2	0.45	0.13	neutral	0.34	neutral	0.35	neutral	0.43	neutral	1	0.61	neutral	0.48	deleterious	-6	neutral	0.29	neutral	-0.66	medium_impact	0.02	medium_impact	-0.97	medium_impact	0.41	0.8	20.69	59.98	0.4	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9320	9320	C	G	MI.6883	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	114	38	H	Q	caC/caG	2.67	0.02	0	benign	0.38	neutral	0.33	neutral	2.35	neutral	0.95	neutral	-1.52	neutral_impact	0.24	0.76	neutral	0.81	neutral	2.00	16.21	deleterious	0.2	0.45	0.13	neutral	0.34	neutral	0.35	neutral	0.43	neutral	1	0.61	neutral	0.48	deleterious	-6	neutral	0.29	neutral	-0.66	medium_impact	0.02	medium_impact	-0.97	medium_impact	0.41	0.8	20.69	59.98	0.4	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9321	9321	T	C	MI.6884	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	115	39	S	P	Tcc/Ccc	-2.42	0	0	benign	0.14	neutral	0.21	neutral	2.23	neutral	-2	deleterious	-2.54	low_impact	1.33	0.58	damaging	0.05	damaging	1.95	15.88	deleterious	0.07	0.35	0.33	neutral	0.87	disease	0.48	neutral	0.7	disease	4	0.76	neutral	0.54	deleterious	-6	neutral	0.38	neutral	-0.1	medium_impact	-0.14	medium_impact	0.01	medium_impact	0.17	0.8	19.92	26.44	0.28	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9321	9321	T	A	MI.6885	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	115	39	S	T	Tcc/Acc	-2.42	0	0	benign	0	neutral	0.4	neutral	2.27	neutral	-0.77	neutral	-0.58	neutral_impact	0.35	0.74	neutral	0.52	neutral	0.47	7.18	deleterious	0.2	0.45	0.17	neutral	0.38	neutral	0.31	neutral	0.45	neutral	1	0.6	neutral	0.7	deleterious	-6	neutral	0.14	neutral	2.05	high_impact	0.09	medium_impact	-0.87	medium_impact	0.41	0.8	19.92	26.44	0.42	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9321	9321	T	G	MI.6886	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	115	39	S	A	Tcc/Gcc	-2.42	0	0	benign	0.02	neutral	0.49	neutral	2.3	neutral	-0.23	neutral	-1.8	low_impact	0.84	0.66	neutral	0.21	damaging	1.69	14.34	neutral	0.27	0.45	0.14	neutral	0.49	neutral	0.47	neutral	0.45	neutral	1	0.49	neutral	0.74	deleterious	-6	neutral	0.15	neutral	0.77	medium_impact	0.18	medium_impact	-0.43	medium_impact	0.25	0.8	19.92	26.44	0.27	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9322	9322	C	T	MI.6887	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	116	39	S	F	tCc/tTc	1.05	0.01	0	possibly_damaging	0.56	neutral	0.73	neutral	2.21	deleterious	-3.16	deleterious	-3.33	low_impact	1.6	0.67	neutral	0.22	damaging	2.18	17.35	deleterious	0.07	0.35	0.36	neutral	0.78	disease	0.55	disease	0.7	disease	4	0.47	neutral	0.59	deleterious	-3	neutral	0.59	deleterious	-0.97	medium_impact	0.44	medium_impact	0.25	medium_impact	0.13	0.8	19.92	26.44	0.23	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9322	9322	C	G	MI.6888	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	116	39	S	C	tCc/tGc	1.05	0.01	0	benign	0.42	neutral	0.17	neutral	2.19	deleterious	-4.21	deleterious	-3.08	medium_impact	2.4	0.63	neutral	0.06	damaging	3.07	22.40	deleterious	0.1	0.4	0.53	disease	0.78	disease	0.61	disease	0.74	disease	5	0.8	neutral	0.38	neutral	-3	neutral	0.55	deleterious	-0.73	medium_impact	-0.2	medium_impact	0.97	medium_impact	0.23	0.8	19.92	26.44	0.27	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9322	9322	C	A	MI.6889	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	116	39	S	Y	tCc/tAc	1.05	0.01	0	possibly_damaging	0.56	neutral	1	neutral	2.21	neutral	-2.82	deleterious	-2.99	low_impact	1.5	0.64	neutral	0.14	damaging	2.25	17.81	deleterious	0.06	0.35	0.35	neutral	0.8	disease	0.57	disease	0.71	disease	4	0.56	neutral	0.72	deleterious	-3	neutral	0.59	deleterious	-0.97	medium_impact	1.9	high_impact	0.16	medium_impact	0.18	0.8	19.92	26.44	0.22	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8851	8851	T	C	MI.689	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	325	109	W	R	Tga/Cga	-6.58	0	0	probably_damaging	1	deleterious	0	neutral	4.18	deleterious	-3.07	deleterious	-12.91	high_impact	4.46	0.41	damaging	0.25	damaging	3.56	23.10	deleterious	0.28	0.65	0.82	disease	0.96	disease	0.79	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.72	high_impact	0.24	0.9	49.12	8.75	0.69	P	0.97	disease_causing_automatic	0.98	0.43	rs199476136	Pathogenic	Leigh_syndrome|Striatonigral_degeneration,_infantile,_mitochondrial	24684	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1839022,OMIM:500003	.	.	.	.	T8851C	BSN / Leigh syndrome	+	+	Cfrm	5	P	P	P	damaging
chrM	9324	9324	A	C	MI.6890	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	118	40	M	L	Ata/Cta	-11.67	0	0	benign	0	neutral	0.85	neutral	2.68	neutral	1.43	neutral	-0.64	neutral_impact	0.04	0.81	neutral	0.92	neutral	-0.25	0.84	neutral	0.24	0.45	0.12	neutral	0.44	neutral	0.47	neutral	0.43	neutral	1	0.15	neutral	0.93	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.62	medium_impact	-1.15	low_impact	0.33	0.8	15.71	12.89	0.33	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9324	9324	A	T	MI.6891	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	118	40	M	L	Ata/Tta	-11.67	0	0	benign	0	neutral	0.85	neutral	2.68	neutral	1.43	neutral	-0.64	neutral_impact	0.04	0.81	neutral	0.92	neutral	-0.12	1.61	neutral	0.24	0.45	0.12	neutral	0.44	neutral	0.47	neutral	0.43	neutral	1	0.15	neutral	0.93	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.62	medium_impact	-1.15	low_impact	0.33	0.8	15.71	12.89	0.33	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9324	9324	A	G	MI.6892	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	118	40	M	V	Ata/Gta	-11.67	0	0	benign	0	neutral	0.47	neutral	2.66	neutral	1.21	neutral	-0.61	neutral_impact	0.46	0.83	neutral	0.97	neutral	-0.55	0.16	neutral	0.21	0.45	0.13	neutral	0.45	neutral	0.51	disease	0.43	neutral	1	0.53	neutral	0.74	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.16	medium_impact	-0.77	medium_impact	0.39	0.8	15.71	12.89	0.28	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9325	9325	T	A	MI.6893	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	119	40	M	K	aTa/aAa	-4.73	0	0.01	benign	0	neutral	0.3	neutral	2.59	neutral	0.02	neutral	-1.41	low_impact	1.23	0.8	neutral	0.61	neutral	0.74	9.09	deleterious	0.05	0.35	0.19	neutral	0.68	disease	0.65	disease	0.55	disease	1	0.7	neutral	0.65	deleterious	-6	neutral	0.14	neutral	2.05	high_impact	-0.02	medium_impact	-0.08	medium_impact	0.28	0.8	15.71	12.89	0.31	N	0.24	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9325	9325	T	C	MI.6894	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	119	40	M	T	aTa/aCa	-4.73	0	0.01	benign	0	neutral	0.56	neutral	2.62	neutral	0.66	neutral	0.04	neutral_impact	0.06	0.8	neutral	0.99	neutral	-1.80	0.00	neutral	0.14	0.4	0.14	neutral	0.28	neutral	0.4	neutral	0.41	neutral	2	0.44	neutral	0.78	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.25	medium_impact	-1.13	low_impact	0.17	0.8	15.71	12.89	0.27	N	0.00	polymorphism	1	0.01	rs879000531	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9326	9326	A	T	MI.6895	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	120	40	M	I	atA/atT	-8.2	0	0	benign	0	neutral	0.38	neutral	2.64	neutral	0.92	neutral	-0.76	neutral_impact	0.42	0.81	neutral	0.98	neutral	0.01	2.64	deleterious	0.2	0.45	0.14	neutral	0.48	neutral	0.33	neutral	0.41	neutral	2	0.62	neutral	0.69	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.07	medium_impact	-0.81	medium_impact	0.42	0.8	15.71	12.89	0.33	N	0.02	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9326	9326	A	C	MI.6896	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	120	40	M	I	atA/atC	-8.2	0	0	benign	0	neutral	0.38	neutral	2.64	neutral	0.92	neutral	-0.76	neutral_impact	0.42	0.81	neutral	0.98	neutral	-0.03	2.35	deleterious	0.2	0.45	0.14	neutral	0.48	neutral	0.33	neutral	0.41	neutral	2	0.62	neutral	0.69	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.07	medium_impact	-0.81	medium_impact	0.42	0.8	15.71	12.89	0.33	N	0.02	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9327	9327	A	C	MI.6897	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	121	41	T	P	Acg/Ccg	-13.06	0	0	benign	0.14	neutral	0.2	neutral	2.52	neutral	-1.32	neutral	-2.31	medium_impact	2.06	0.66	neutral	0.51	neutral	1.83	15.18	deleterious	0.06	0.35	0.22	neutral	0.74	disease	0.58	disease	0.69	disease	4	0.77	neutral	0.53	deleterious	-3	neutral	0.27	neutral	-0.1	medium_impact	-0.15	medium_impact	0.66	medium_impact	0.40	0.8	8.81	20.19	0.4	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9327	9327	A	T	MI.6898	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	121	41	T	S	Acg/Tcg	-13.06	0	0	benign	0.01	neutral	0.41	neutral	2.55	neutral	-0.56	neutral	-0.38	low_impact	0.86	0.8	neutral	0.85	neutral	-0.54	0.18	neutral	0.27	0.45	0.13	neutral	0.2	neutral	0.22	neutral	0.35	neutral	3	0.58	neutral	0.7	deleterious	-6	neutral	0.07	neutral	1.07	medium_impact	0.1	medium_impact	-0.41	medium_impact	0.60	0.8	8.81	20.19	0.41	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9327	9327	A	G	MI.6899	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	121	41	T	A	Acg/Gcg	-13.06	0	0	benign	0	neutral	0.36	neutral	2.57	neutral	-0.25	neutral	-1.23	low_impact	1.09	0.8	neutral	0.99	neutral	-0.08	1.86	neutral	0.2	0.45	0.11	neutral	0.29	neutral	0.39	neutral	0.42	neutral	2	0.64	neutral	0.68	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	0.05	medium_impact	-0.21	medium_impact	0.38	0.8	8.81	20.19	0.38	N	0.16	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8556	8556	T	G	MI.69	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	30	10	I	M	atT/atG	-0.33	0	0	benign	0.04	neutral	0.29	neutral	4.68	neutral	-1.06	neutral	0.07	neutral_impact	0.21	0.9	neutral	0.93	neutral	4.01	23.60	deleterious	0.43	0.65	0.6	disease	0.09	neutral	0.18	neutral	0.36	neutral	3	0.69	neutral	0.63	deleterious	-6	neutral	0.19	neutral	0.55	medium_impact	0.07	medium_impact	-0.92	medium_impact	0.40	0.9	27.43	16.7	0.61	P	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8851	8851	T	G	MI.690	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	325	109	W	G	Tga/Gga	-6.58	0	0	probably_damaging	0.99	deleterious	0	neutral	4.15	neutral	-2.76	deleterious	-11.98	high_impact	4.46	0.62	neutral	0.42	neutral	3.87	23.50	deleterious	0.24	0.65	0.83	disease	0.92	disease	0.75	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-2.65	low_impact	-1.4	low_impact	2.72	high_impact	0.28	0.9	49.12	8.75	0.5	N	1.00	disease_causing	0.99	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9328	9328	C	T	MI.6900	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	122	41	T	M	aCg/aTg	-4.27	0	0	benign	0.28	neutral	0.36	neutral	2.55	neutral	-0.63	neutral	-1.19	low_impact	0.88	0.75	neutral	0.68	neutral	2.45	19.13	deleterious	0.15	0.4	0.27	neutral	0.34	neutral	0.26	neutral	0.45	neutral	1	0.56	neutral	0.54	deleterious	-6	neutral	0.29	neutral	-0.47	medium_impact	0.05	medium_impact	-0.39	medium_impact	0.53	0.8	8.81	20.19	0.47	N	0.82	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9328	9328	C	A	MI.6901	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	122	41	T	K	aCg/aAg	-4.27	0	0	benign	0.03	neutral	0.2	neutral	2.53	neutral	-1.1	neutral	-1.62	low_impact	1.46	0.7	neutral	0.56	neutral	1.30	12.29	neutral	0.1	0.4	0.13	neutral	0.63	disease	0.56	disease	0.45	neutral	1	0.79	neutral	0.59	deleterious	-6	neutral	0.18	neutral	0.6	medium_impact	-0.15	medium_impact	0.13	medium_impact	0.43	0.8	8.81	20.19	0.37	N	0.86	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9330	9330	C	T	MI.6902	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	124	42	L	F	Ctc/Ttc	-8.66	0	0	probably_damaging	1	neutral	0.43	neutral	2.08	neutral	-1.97	deleterious	-2.95	medium_impact	2.04	0.59	damaging	0.11	damaging	3.79	23.40	deleterious	0.29	0.45	0.3	neutral	0.58	disease	0.57	disease	0.49	neutral	0	1	deleterious	0.22	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	0.12	medium_impact	0.65	medium_impact	0.64	0.8	76.25	10.63	0.19	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9330	9330	C	A	MI.6903	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	124	42	L	I	Ctc/Atc	-8.66	0	0	probably_damaging	0.99	neutral	0.22	neutral	2.15	neutral	-1.15	neutral	-1.13	low_impact	1.08	0.67	neutral	0.41	neutral	2.69	20.80	deleterious	0.3	0.45	0.17	neutral	0.48	neutral	0.37	neutral	0.44	neutral	1	0.99	deleterious	0.12	neutral	-2	neutral	0.66	deleterious	-2.81	low_impact	-0.12	medium_impact	-0.22	medium_impact	0.50	0.8	76.25	10.63	0.43	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9330	9330	C	G	MI.6904	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	124	42	L	V	Ctc/Gtc	-8.66	0	0	probably_damaging	0.98	neutral	0.21	neutral	2.16	neutral	-1.03	neutral	-1.71	low_impact	0.91	0.68	neutral	0.48	neutral	2.23	17.68	deleterious	0.31	0.45	0.21	neutral	0.41	neutral	0.4	neutral	0.44	neutral	1	0.98	deleterious	0.12	neutral	-2	neutral	0.65	deleterious	-2.51	low_impact	-0.14	medium_impact	-0.37	medium_impact	0.74	0.85	76.25	10.63	0.41	N	0.81	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9331	9331	T	C	MI.6905	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	125	42	L	P	cTc/cCc	-1.03	0	0	probably_damaging	1	neutral	0.07	neutral	2.01	deleterious	-4.01	deleterious	-5.04	medium_impact	2.52	0.61	neutral	0.05	damaging	3.69	23.30	deleterious	0.02	0.35	0.62	disease	0.8	disease	0.75	disease	0.64	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.83	deleterious	-3.78	low_impact	-0.45	medium_impact	1.08	medium_impact	0.34	0.8	76.25	10.63	0.24	N	0.99	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9331	9331	T	G	MI.6906	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	125	42	L	R	cTc/cGc	-1.03	0	0	probably_damaging	1	neutral	0.08	neutral	2.03	deleterious	-3.2	deleterious	-4.48	medium_impact	3.46	0.59	damaging	0.03	damaging	4.04	23.70	deleterious	0.02	0.35	0.53	disease	0.89	disease	0.76	disease	0.81	disease	6	1	deleterious	0.04	neutral	1	deleterious	0.85	deleterious	-3.78	low_impact	-0.41	medium_impact	1.92	medium_impact	0.24	0.8	76.25	10.63	0.32	N	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9331	9331	T	A	MI.6907	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	125	42	L	H	cTc/cAc	-1.03	0	0	probably_damaging	1	neutral	0.13	neutral	2.01	deleterious	-3.94	deleterious	-5.21	medium_impact	3.46	0.61	neutral	0.05	damaging	3.98	23.60	deleterious	0.04	0.35	0.62	disease	0.8	disease	0.73	disease	0.75	disease	5	1	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	-0.28	medium_impact	1.92	medium_impact	0.18	0.8	76.25	10.63	0.27	N	0.97	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9333	9333	C	A	MI.6908	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	127	43	L	I	Ctc/Atc	-7.51	0	0	probably_damaging	0.98	neutral	0.3	neutral	1.95	neutral	-2	neutral	-0.95	medium_impact	2.02	0.68	neutral	0.78	neutral	2.82	21.50	deleterious	0.26	0.45	0.17	neutral	0.47	neutral	0.32	neutral	0.45	neutral	1	0.99	deleterious	0.16	neutral	1	deleterious	0.65	deleterious	-2.51	low_impact	-0.02	medium_impact	0.63	medium_impact	0.46	0.8	78.16	10.28	0.45	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9333	9333	C	T	MI.6909	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	127	43	L	F	Ctc/Ttc	-7.51	0	0	probably_damaging	0.99	neutral	0.41	neutral	1.95	neutral	-2.07	neutral	-1.6	low_impact	0.9	0.75	neutral	0.75	neutral	2.66	20.60	deleterious	0.25	0.45	0.16	neutral	0.24	neutral	0.32	neutral	0.43	neutral	1	0.99	deleterious	0.21	neutral	-2	neutral	0.66	deleterious	-2.81	low_impact	0.1	medium_impact	-0.38	medium_impact	0.59	0.8	78.16	10.28	0.33	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8852	8852	G	C	MI.691	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	326	109	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	deleterious	0	neutral	4.23	neutral	-1.83	deleterious	-12.89	high_impact	4.46	0.59	damaging	0.44	neutral	4.00	23.60	deleterious	0.23	0.65	0.55	disease	0.95	disease	0.73	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.72	high_impact	0.23	0.9	49.12	8.75	0.5	P	0.98	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9333	9333	C	G	MI.6910	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	127	43	L	V	Ctc/Gtc	-7.51	0	0	probably_damaging	0.96	neutral	0.28	neutral	1.98	neutral	-1.77	neutral	-1.57	low_impact	1.8	0.73	neutral	0.77	neutral	3.23	22.80	deleterious	0.26	0.45	0.14	neutral	0.39	neutral	0.33	neutral	0.44	neutral	1	0.96	neutral	0.16	neutral	-2	neutral	0.63	deleterious	-2.21	low_impact	-0.04	medium_impact	0.43	medium_impact	0.66	0.8	78.16	10.28	0.39	N	0.81	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9334	9334	T	C	MI.6911	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	128	43	L	P	cTc/cCc	-1.26	0	0	probably_damaging	1	neutral	0.06	neutral	1.82	deleterious	-5.18	deleterious	-4.74	medium_impact	2.9	0.57	damaging	0.33	neutral	3.75	23.30	deleterious	0.02	0.35	0.48	neutral	0.84	disease	0.68	disease	0.76	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.82	deleterious	-3.78	low_impact	-0.49	medium_impact	1.42	medium_impact	0.40	0.8	78.16	10.28	0.28	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9334	9334	T	G	MI.6912	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	128	43	L	R	cTc/cGc	-1.26	0	0	probably_damaging	1	neutral	0.08	neutral	1.83	deleterious	-4.51	deleterious	-4.08	high_impact	3.88	0.56	damaging	0.35	neutral	4.05	23.70	deleterious	0.02	0.35	0.36	neutral	0.87	disease	0.69	disease	0.76	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.41	medium_impact	2.3	high_impact	0.24	0.8	78.16	10.28	0.35	N	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9334	9334	T	A	MI.6913	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	128	43	L	H	cTc/cAc	-1.26	0	0	probably_damaging	1	neutral	0.13	neutral	1.82	deleterious	-5.13	deleterious	-4.42	high_impact	3.88	0.63	neutral	0.42	neutral	3.99	23.60	deleterious	0.04	0.35	0.46	neutral	0.76	disease	0.65	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	-0.28	medium_impact	2.3	high_impact	0.26	0.8	78.16	10.28	0.41	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9336	9336	A	G	MI.6914	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	130	44	M	V	Ata/Gta	-4.5	0	0.01	benign	0	neutral	0.35	neutral	2.66	neutral	1.27	neutral	-0.32	neutral_impact	-0.86	0.83	neutral	0.93	neutral	-1.22	0.01	neutral	0.22	0.45	0.09	neutral	0.23	neutral	0.43	neutral	0.4	neutral	2	0.65	neutral	0.68	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	0.04	medium_impact	-1.95	low_impact	0.35	0.8	14.18	14.3	0.31	N	0.30	polymorphism	1	0.01	rs28474779	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9336	9336	A	T	MI.6915	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	130	44	M	L	Ata/Tta	-4.5	0	0.01	benign	0	neutral	1	neutral	2.74	neutral	1.48	neutral	-0.15	neutral_impact	-1.4	0.8	neutral	0.94	neutral	-1.08	0.01	neutral	0.2	0.45	0.08	neutral	0.18	neutral	0.28	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	1.9	high_impact	-2.44	low_impact	0.28	0.8	14.18	14.3	0.37	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9336	9336	A	C	MI.6916	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	130	44	M	L	Ata/Cta	-4.5	0	0.01	benign	0	neutral	1	neutral	2.74	neutral	1.48	neutral	-0.15	neutral_impact	-1.4	0.8	neutral	0.94	neutral	-1.18	0.01	neutral	0.2	0.45	0.08	neutral	0.18	neutral	0.28	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	1.9	high_impact	-2.44	low_impact	0.28	0.8	14.18	14.3	0.36	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9337	9337	T	C	MI.6917	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	131	44	M	T	aTa/aCa	-7.04	0	0	benign	0	neutral	0.39	neutral	2.62	neutral	0.24	neutral	-0.46	neutral_impact	-0.42	0.82	neutral	0.99	neutral	-1.36	0.00	neutral	0.11	0.4	0.08	neutral	0.2	neutral	0.32	neutral	0.33	neutral	3	0.61	neutral	0.7	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	0.08	medium_impact	-1.56	low_impact	0.20	0.8	14.18	14.3	0.33	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9337	9337	T	A	MI.6918	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	131	44	M	K	aTa/aAa	-7.04	0	0	benign	0	neutral	0.22	neutral	2.58	neutral	-1	neutral	-1.41	neutral_impact	0.38	0.77	neutral	0.68	neutral	0.25	5.16	deleterious	0.04	0.35	0.09	neutral	0.51	disease	0.53	disease	0.43	neutral	1	0.78	neutral	0.61	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	-0.12	medium_impact	-0.84	medium_impact	0.29	0.8	14.18	14.3	0.35	N	0.44	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9338	9338	A	T	MI.6919	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	132	44	M	I	atA/atT	-4.27	0	0	benign	0	neutral	0.47	neutral	2.66	neutral	1.12	neutral	-0.4	neutral_impact	-0.81	0.81	neutral	0.91	neutral	-0.72	0.07	neutral	0.27	0.45	0.08	neutral	0.18	neutral	0.28	neutral	0.28	neutral	4	0.53	neutral	0.74	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	0.16	medium_impact	-1.91	low_impact	0.34	0.8	14.18	14.3	0.34	N	0.17	disease_causing	1	0.01	rs386829075	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8852	8852	G	T	MI.692	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	326	109	W	L	tGa/tTa	7.53	1	0	probably_damaging	0.99	deleterious	0.04	neutral	4.25	neutral	-0.26	deleterious	-11.99	medium_impact	2.82	0.6	neutral	0.37	neutral	4.21	23.90	deleterious	0.22	0.65	0.38	neutral	0.91	disease	0.72	disease	0.65	disease	3	1	deleterious	0.03	neutral	5	deleterious	0.80	deleterious	-2.65	low_impact	-0.49	medium_impact	1.32	medium_impact	0.26	0.9	49.12	8.75	0.45	N	1.00	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9338	9338	A	C	MI.6920	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	132	44	M	I	atA/atC	-4.27	0	0	benign	0	neutral	0.47	neutral	2.66	neutral	1.12	neutral	-0.4	neutral_impact	-0.81	0.81	neutral	0.91	neutral	-0.78	0.05	neutral	0.27	0.45	0.08	neutral	0.18	neutral	0.28	neutral	0.28	neutral	4	0.53	neutral	0.74	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	0.16	medium_impact	-1.91	low_impact	0.34	0.8	14.18	14.3	0.33	N	0.17	disease_causing	1	0.01	rs386829075	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9339	9339	C	G	MI.6921	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	133	45	L	V	Cta/Gta	-11.9	0	0	benign	0.09	neutral	0.24	neutral	2.14	neutral	-1.13	neutral	-1.49	low_impact	1.29	0.7	neutral	0.47	neutral	1.25	12.02	neutral	0.28	0.45	0.16	neutral	0.36	neutral	0.34	neutral	0.44	neutral	1	0.73	neutral	0.58	deleterious	-6	neutral	0.15	neutral	0.11	medium_impact	-0.09	medium_impact	-0.03	medium_impact	0.62	0.8	20.69	31.76	0.45	N	0.08	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9339	9339	C	A	MI.6922	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	133	45	L	M	Cta/Ata	-11.9	0	0	possibly_damaging	0.62	neutral	0.18	neutral	2.07	neutral	-1.89	neutral	-1.02	medium_impact	1.95	0.72	neutral	0.73	neutral	2.12	16.96	deleterious	0.27	0.45	0.29	neutral	0.27	neutral	0.33	neutral	0.43	neutral	1	0.83	neutral	0.28	neutral	0	NA	0.41	neutral	-1.08	low_impact	-0.18	medium_impact	0.57	medium_impact	0.38	0.8	20.69	31.76	0.5	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9340	9340	T	G	MI.6923	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	134	45	L	R	cTa/cGa	-10.51	0	0	benign	0.38	neutral	0.13	neutral	2	deleterious	-3.57	deleterious	-4.62	high_impact	3.87	0.54	damaging	0.02	damaging	3.72	23.30	deleterious	0.02	0.35	0.56	disease	0.84	disease	0.71	disease	0.78	disease	6	0.85	neutral	0.38	neutral	-2	neutral	0.46	deleterious	-0.66	medium_impact	-0.28	medium_impact	2.29	high_impact	0.19	0.8	20.69	31.76	0.31	N	0.77	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9340	9340	T	A	MI.6924	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	134	45	L	Q	cTa/cAa	-10.51	0	0	possibly_damaging	0.54	neutral	0.11	neutral	2	deleterious	-3.63	deleterious	-4.5	high_impact	3.87	0.6	damaging	0.09	damaging	4.02	23.60	deleterious	0.03	0.35	0.57	disease	0.72	disease	0.59	disease	0.69	disease	4	0.88	neutral	0.29	neutral	1	deleterious	0.49	deleterious	-0.94	medium_impact	-0.33	medium_impact	2.29	high_impact	0.24	0.8	20.69	31.76	0.3	N	0.61	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9340	9340	T	C	MI.6925	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	134	45	L	P	cTa/cCa	-10.51	0	0	possibly_damaging	0.54	neutral	0.08	neutral	1.99	deleterious	-4.27	deleterious	-5.22	medium_impact	3.31	0.54	damaging	0.03	damaging	3.54	23.10	deleterious	0.02	0.35	0.64	disease	0.78	disease	0.72	disease	0.74	disease	5	0.91	neutral	0.27	neutral	0	NA	0.56	deleterious	-0.94	medium_impact	-0.41	medium_impact	1.78	medium_impact	0.33	0.8	20.69	31.76	0.27	N	0.84	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9342	9342	G	T	MI.6926	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	136	46	G	C	Ggc/Tgc	-2.42	0	0	probably_damaging	0.92	neutral	0.19	neutral	2.12	deleterious	-5.58	deleterious	-6.42	medium_impact	3.02	0.58	damaging	0.24	damaging	3.96	23.60	deleterious	0.06	0.35	0.59	disease	0.83	disease	0.6	disease	0.67	disease	3	0.95	neutral	0.14	neutral	1	deleterious	0.74	deleterious	-1.9	low_impact	-0.17	medium_impact	1.52	medium_impact	0.19	0.8	71.65	11.12	0.28	N	0.85	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9342	9342	G	A	MI.6927	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	136	46	G	S	Ggc/Agc	-2.42	0	0	benign	0.04	neutral	0.42	neutral	2.3	neutral	-2.39	deleterious	-3.77	low_impact	1.76	0.53	damaging	0.87	neutral	2.16	17.27	deleterious	0.11	0.4	0.16	neutral	0.52	disease	0.4	neutral	0.42	neutral	2	0.55	neutral	0.69	deleterious	-6	neutral	0.16	neutral	0.47	medium_impact	0.11	medium_impact	0.4	medium_impact	0.65	0.8	71.65	11.12	0.47	N	0.39	polymorphism	1	0.10	rs28672157	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9342	9342	G	C	MI.6928	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	136	46	G	R	Ggc/Cgc	-2.42	0	0	possibly_damaging	0.88	neutral	0.36	neutral	2.13	deleterious	-4.65	deleterious	-5.88	high_impact	4.34	0.65	neutral	0.2	damaging	3.70	23.30	deleterious	0.05	0.35	0.25	neutral	0.87	disease	0.77	disease	0.75	disease	5	0.89	neutral	0.24	neutral	1	deleterious	0.74	deleterious	-1.71	low_impact	0.05	medium_impact	2.71	high_impact	0.44	0.8	71.65	11.12	0.47	N	1.00	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9343	9343	G	C	MI.6929	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	137	46	G	A	gGc/gCc	5.22	1	0	benign	0.13	neutral	0.51	neutral	2.28	neutral	-2.45	deleterious	-3.71	medium_impact	2.17	0.59	damaging	0.55	neutral	1.32	12.39	neutral	0.16	0.45	0.14	neutral	0.45	neutral	0.41	neutral	0.39	neutral	2	0.4	neutral	0.69	deleterious	-3	neutral	0.29	neutral	-0.07	medium_impact	0.2	medium_impact	0.76	medium_impact	0.41	0.8	71.65	11.12	0.54	P	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8853	8853	A	C	MI.693	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	327	109	W	C	tgA/tgC	9.15	1	0	probably_damaging	1	deleterious	0	neutral	4.15	deleterious	-3.36	deleterious	-12.01	high_impact	4.12	0.53	damaging	0.24	damaging	4.00	23.60	deleterious	0.27	0.65	0.86	disease	0.94	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.43	high_impact	0.27	0.9	49.12	8.75	0.49	N	1.00	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9343	9343	G	A	MI.6930	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	137	46	G	D	gGc/gAc	5.22	1	0	possibly_damaging	0.59	neutral	0.2	neutral	2.12	deleterious	-4.68	deleterious	-5.17	high_impact	4.34	0.64	neutral	0.23	damaging	3.71	23.30	deleterious	0.06	0.35	0.24	neutral	0.83	disease	0.76	disease	0.75	disease	5	0.8	neutral	0.31	neutral	1	deleterious	0.62	deleterious	-1.02	low_impact	-0.15	medium_impact	2.71	high_impact	0.26	0.8	71.65	11.12	0.56	P	0.95	polymorphism	1	0.23	.	.	.	.	.	.	COSM1138425	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9343	9343	G	T	MI.6931	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	137	46	G	V	gGc/gTc	5.22	1	0	possibly_damaging	0.84	neutral	0.54	neutral	2.14	deleterious	-4.06	deleterious	-6.44	high_impact	3.65	0.57	damaging	0.29	neutral	3.57	23.10	deleterious	0.07	0.35	0.29	neutral	0.78	disease	0.67	disease	0.69	disease	4	0.82	neutral	0.35	neutral	1	deleterious	0.68	deleterious	-1.57	low_impact	0.23	medium_impact	2.09	high_impact	0.19	0.8	71.65	11.12	0.47	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9345	9345	C	A	MI.6932	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	139	47	L	M	Cta/Ata	-9.13	0	0	benign	0.01	neutral	0.37	neutral	1.99	neutral	-2.38	neutral	-0.53	medium_impact	2.21	0.69	neutral	0.43	neutral	0.45	7.02	deleterious	0.27	0.45	0.22	neutral	0.29	neutral	0.26	neutral	0.44	neutral	1	0.62	neutral	0.68	deleterious	-3	neutral	0.13	neutral	1.07	medium_impact	0.06	medium_impact	0.8	medium_impact	0.50	0.8	64.75	11.98	0.51	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9345	9345	C	G	MI.6933	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	139	47	L	V	Cta/Gta	-9.13	0	0	benign	0.01	neutral	0.48	neutral	2.07	neutral	-1.45	neutral	-1.31	low_impact	1.69	0.72	neutral	0.27	damaging	0.31	5.81	deleterious	0.25	0.45	0.16	neutral	0.31	neutral	0.26	neutral	0.45	neutral	1	0.5	neutral	0.74	deleterious	-6	neutral	0.13	neutral	1.07	medium_impact	0.17	medium_impact	0.33	medium_impact	0.51	0.8	64.75	11.98	0.36	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9346	9346	T	A	MI.6934	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	140	47	L	Q	cTa/cAa	-2.88	0	0	benign	0.32	neutral	0.22	neutral	1.93	deleterious	-3.96	deleterious	-3.56	high_impact	3.56	0.67	neutral	0.1	damaging	3.74	23.30	deleterious	0.06	0.35	0.28	neutral	0.7	disease	0.51	disease	0.55	disease	1	0.74	neutral	0.45	neutral	-2	neutral	0.44	deleterious	-0.55	medium_impact	-0.12	medium_impact	2.01	high_impact	0.23	0.8	64.75	11.98	0.34	N	0.87	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9346	9346	T	C	MI.6935	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	140	47	L	P	cTa/cCa	-2.88	0	0	possibly_damaging	0.68	neutral	0.15	neutral	1.91	deleterious	-4.65	deleterious	-4.44	high_impact	3.56	0.55	damaging	0.06	damaging	3.69	23.30	deleterious	0.04	0.35	0.29	neutral	0.81	disease	0.66	disease	0.74	disease	5	0.87	neutral	0.24	neutral	1	deleterious	0.69	deleterious	-1.19	low_impact	-0.24	medium_impact	2.01	high_impact	0.32	0.8	64.75	11.98	0.27	N	0.93	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9346	9346	T	G	MI.6936	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	140	47	L	R	cTa/cGa	-2.88	0	0	benign	0.32	neutral	0.26	neutral	1.93	deleterious	-3.92	deleterious	-3.82	high_impact	3.92	0.56	damaging	0.06	damaging	3.89	23.50	deleterious	0.04	0.35	0.28	neutral	0.84	disease	0.65	disease	0.75	disease	5	0.69	neutral	0.47	deleterious	-2	neutral	0.51	deleterious	-0.55	medium_impact	-0.07	medium_impact	2.33	high_impact	0.21	0.8	64.75	11.98	0.34	N	0.97	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9348	9348	C	A	MI.6937	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	142	48	L	M	Cta/Ata	-2.65	0	0	possibly_damaging	0.49	neutral	0.28	neutral	2.15	neutral	-2.02	neutral	-0.7	low_impact	1.48	0.76	neutral	0.92	neutral	2.23	17.71	deleterious	0.25	0.45	0.25	neutral	0.24	neutral	0.28	neutral	0.44	neutral	1	0.69	neutral	0.4	neutral	-3	neutral	0.34	neutral	-0.85	medium_impact	-0.04	medium_impact	0.14	medium_impact	0.52	0.8	16.86	19.7	0.48	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9348	9348	C	G	MI.6938	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	142	48	L	V	Cta/Gta	-2.65	0	0	benign	0	neutral	0.57	neutral	2.32	neutral	-0.04	neutral	-0.38	neutral_impact	0.55	0.77	neutral	0.93	neutral	-0.37	0.45	neutral	0.21	0.45	0.13	neutral	0.18	neutral	0.28	neutral	0.29	neutral	4	0.42	neutral	0.79	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	0.26	medium_impact	-0.69	medium_impact	0.41	0.8	16.86	19.7	0.32	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9349	9349	T	A	MI.6939	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	143	48	L	Q	cTa/cAa	-7.97	0	0	benign	0.41	neutral	0.16	neutral	2.12	neutral	-2.92	deleterious	-3.62	medium_impact	3.41	0.7	neutral	0.16	damaging	3.92	23.50	deleterious	0.06	0.35	0.36	neutral	0.56	disease	0.51	disease	0.53	disease	1	0.81	neutral	0.38	neutral	-3	neutral	0.37	neutral	-0.72	medium_impact	-0.22	medium_impact	1.87	medium_impact	0.27	0.8	16.86	19.7	0.36	N	0.73	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8853	8853	A	T	MI.694	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	327	109	W	C	tgA/tgT	9.15	1	0	probably_damaging	1	deleterious	0	neutral	4.15	deleterious	-3.36	deleterious	-12.01	high_impact	4.12	0.53	damaging	0.24	damaging	4.08	23.70	deleterious	0.27	0.65	0.86	disease	0.94	disease	0.75	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.43	high_impact	0.27	0.9	49.12	8.75	0.49	N	1.00	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9349	9349	T	C	MI.6940	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	143	48	L	P	cTa/cCa	-7.97	0	0	benign	0.3	neutral	0.11	neutral	2.11	deleterious	-3.57	deleterious	-4.11	medium_impact	2.61	0.59	damaging	0.12	damaging	3.59	23.20	deleterious	0.04	0.35	0.45	neutral	0.78	disease	0.66	disease	0.71	disease	4	0.87	neutral	0.41	neutral	-3	neutral	0.51	deleterious	-0.51	medium_impact	-0.33	medium_impact	1.16	medium_impact	0.37	0.8	16.86	19.7	0.27	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9349	9349	T	G	MI.6941	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	143	48	L	R	cTa/cGa	-7.97	0	0	benign	0.34	neutral	0.19	neutral	2.12	neutral	-2.85	deleterious	-3.8	medium_impact	3.41	0.6	damaging	0.11	damaging	3.86	23.50	deleterious	0.04	0.35	0.34	neutral	0.79	disease	0.64	disease	0.74	disease	5	0.77	neutral	0.43	neutral	-3	neutral	0.42	neutral	-0.59	medium_impact	-0.17	medium_impact	1.87	medium_impact	0.21	0.8	16.86	19.7	0.3	N	0.88	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9351	9351	A	T	MI.6942	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	145	49	T	S	Acc/Tcc	-3.57	0	0	probably_damaging	0.95	neutral	0.26	neutral	2.58	neutral	-0.37	neutral	-1	neutral_impact	-0.03	0.71	neutral	0.46	neutral	1.88	15.45	deleterious	0.35	0.5	0.1	neutral	0.2	neutral	0.23	neutral	0.35	neutral	3	0.96	neutral	0.16	neutral	-2	neutral	0.62	deleterious	-2.11	low_impact	-0.07	medium_impact	-1.21	low_impact	0.55	0.8	21.46	32.35	0.4	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9351	9351	A	G	MI.6943	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	145	49	T	A	Acc/Gcc	-3.57	0	0	probably_damaging	0.95	neutral	0.24	neutral	2.59	neutral	0.18	neutral	-0.31	neutral_impact	0.5	0.66	neutral	0.36	neutral	2.01	16.30	deleterious	0.24	0.45	0.14	neutral	0.27	neutral	0.35	neutral	0.42	neutral	2	0.97	neutral	0.15	neutral	-2	neutral	0.62	deleterious	-2.11	low_impact	-0.09	medium_impact	-0.73	medium_impact	0.31	0.8	21.46	32.35	0.38	N	0.56	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9351	9351	A	C	MI.6944	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	145	49	T	P	Acc/Ccc	-3.57	0	0	probably_damaging	0.99	neutral	0.05	neutral	2.51	neutral	-2.33	neutral	-2.14	medium_impact	2.1	0.57	damaging	0.06	damaging	3.32	22.90	deleterious	0.06	0.35	0.35	neutral	0.77	disease	0.61	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.75	deleterious	-2.81	low_impact	-0.54	medium_impact	0.7	medium_impact	0.33	0.8	21.46	32.35	0.23	N	0.93	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9352	9352	C	T	MI.6945	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	146	49	T	I	aCc/aTc	0.36	0	0	probably_damaging	1	neutral	0.65	neutral	2.62	neutral	0.63	neutral	1.6	neutral_impact	-0.1	0.68	neutral	0.45	neutral	1.68	14.32	neutral	0.11	0.4	0.1	neutral	0.22	neutral	0.22	neutral	0.36	neutral	3	1	deleterious	0.33	neutral	-2	neutral	0.64	deleterious	-3.78	low_impact	0.35	medium_impact	-1.27	low_impact	0.48	0.8	21.46	32.35	0.29	N	0.83	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9352	9352	C	A	MI.6946	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	146	49	T	N	aCc/aAc	0.36	0	0	probably_damaging	0.99	neutral	0.14	neutral	2.52	neutral	-1.76	neutral	-2.08	low_impact	1.25	0.72	neutral	0.12	damaging	3.59	23.20	deleterious	0.26	0.45	0.19	neutral	0.52	disease	0.37	neutral	0.48	neutral	0	1	deleterious	0.08	neutral	-2	neutral	0.67	deleterious	-2.81	low_impact	-0.26	medium_impact	-0.06	medium_impact	0.62	0.8	21.46	32.35	0.3	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9352	9352	C	G	MI.6947	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	146	49	T	S	aCc/aGc	0.36	0	0	probably_damaging	0.95	neutral	0.26	neutral	2.58	neutral	-0.37	neutral	-1	neutral_impact	-0.03	0.71	neutral	0.46	neutral	2.06	16.61	deleterious	0.35	0.5	0.1	neutral	0.2	neutral	0.23	neutral	0.35	neutral	3	0.96	neutral	0.16	neutral	-2	neutral	0.62	deleterious	-2.11	low_impact	-0.07	medium_impact	-1.21	low_impact	0.55	0.8	21.46	32.35	0.42	N	0.23	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9354	9354	A	C	MI.6948	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	148	50	N	H	Aac/Cac	-11.67	0	0	possibly_damaging	0.61	deleterious	0.04	neutral	2.58	neutral	-0.49	neutral	-0.9	low_impact	1.45	0.72	neutral	0.47	neutral	2.80	21.40	deleterious	0.25	0.45	0.29	neutral	0.24	neutral	0.56	disease	0.46	neutral	1	0.96	neutral	0.22	neutral	1	deleterious	0.55	deleterious	-1.06	low_impact	-0.6	medium_impact	0.12	medium_impact	0.33	0.8	24.9	36.4	0.48	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9354	9354	A	T	MI.6949	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	148	50	N	Y	Aac/Tac	-11.67	0	0	possibly_damaging	0.65	neutral	0.07	neutral	2.6	neutral	0.44	neutral	-0.15	low_impact	1.09	0.69	neutral	0.49	neutral	3.47	23.00	deleterious	0.12	0.4	0.28	neutral	0.33	neutral	0.49	neutral	0.45	neutral	1	0.93	neutral	0.21	neutral	-3	neutral	0.58	deleterious	-1.13	low_impact	-0.45	medium_impact	-0.21	medium_impact	0.33	0.8	24.9	36.4	0.48	N	0.96	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8854	8854	G	C	MI.695	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	328	110	A	P	Gcg/Ccg	1.29	0.99	0.01	possibly_damaging	0.55	deleterious	0	neutral	4.29	deleterious	-3.16	deleterious	-3.28	low_impact	1.7	0.71	neutral	0.34	neutral	3.46	23.00	deleterious	0.14	0.65	0.84	disease	0.91	disease	0.62	disease	0.75	disease	5	1	deleterious	0.23	neutral	1	deleterious	0.76	deleterious	-0.84	medium_impact	-1.4	low_impact	0.36	medium_impact	0.84	0.9	22.12	15.91	0.32	N	0.97	disease_causing	0.64	0.10	rs386829055	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9354	9354	A	G	MI.6950	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	148	50	N	D	Aac/Gac	-11.67	0	0	benign	0.06	deleterious	0.01	neutral	2.58	neutral	-0.93	neutral	-0.9	low_impact	1.45	0.66	neutral	0.51	neutral	1.93	15.76	deleterious	0.38	0.5	0.15	neutral	0.27	neutral	0.55	disease	0.45	neutral	1	0.99	deleterious	0.48	deleterious	-2	neutral	0.19	neutral	0.29	medium_impact	-0.95	medium_impact	0.12	medium_impact	0.43	0.8	24.9	36.4	0.45	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9355	9355	A	G	MI.6951	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	149	50	N	S	aAc/aGc	2.44	0.01	0.01	benign	0	deleterious	0.04	neutral	2.61	neutral	1.07	neutral	0.49	neutral_impact	0.34	0.74	neutral	0.78	neutral	-0.02	2.38	deleterious	0.37	0.5	0.14	neutral	0.15	neutral	0.28	neutral	0.3	neutral	4	0.96	neutral	0.52	deleterious	-2	neutral	0.10	neutral	2.05	high_impact	-0.6	medium_impact	-0.88	medium_impact	0.35	0.8	24.9	36.4	0.54	P	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9355	9355	A	T	MI.6952	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	149	50	N	I	aAc/aTc	2.44	0.01	0.01	benign	0.2	neutral	1	neutral	2.73	neutral	2.53	neutral	2.07	neutral_impact	-1.86	0.77	neutral	0.78	neutral	1.80	14.97	neutral	0.13	0.4	0.11	neutral	0.2	neutral	0.2	neutral	0.34	neutral	3	0.2	neutral	0.9	deleterious	-6	neutral	0.31	neutral	-0.28	medium_impact	1.9	high_impact	-2.85	low_impact	0.27	0.8	24.9	36.4	0.37	N	0.98	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9355	9355	A	C	MI.6953	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	149	50	N	T	aAc/aCc	2.44	0.01	0.01	benign	0	neutral	0.4	neutral	2.67	neutral	1.47	neutral	1.97	neutral_impact	-1.44	0.72	neutral	0.79	neutral	-0.97	0.02	neutral	0.21	0.45	0.14	neutral	0.08	neutral	0.2	neutral	0.28	neutral	4	0.6	neutral	0.7	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.09	medium_impact	-2.47	low_impact	0.41	0.8	24.9	36.4	0.51	N	0.73	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9356	9356	C	A	MI.6954	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	150	50	N	K	aaC/aaA	0.36	0	0	benign	0.13	deleterious	0.02	neutral	2.6	neutral	0.21	neutral	-0.35	low_impact	1.45	0.67	neutral	0.44	neutral	2.55	19.79	deleterious	0.25	0.45	0.14	neutral	0.31	neutral	0.55	disease	0.46	neutral	1	0.98	neutral	0.45	neutral	-2	neutral	0.33	neutral	-0.07	medium_impact	-0.77	medium_impact	0.12	medium_impact	0.44	0.8	24.9	36.4	0.45	N	0.97	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9356	9356	C	G	MI.6955	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	150	50	N	K	aaC/aaG	0.36	0	0	benign	0.13	deleterious	0.02	neutral	2.6	neutral	0.21	neutral	-0.35	low_impact	1.45	0.67	neutral	0.44	neutral	2.11	16.89	deleterious	0.25	0.45	0.14	neutral	0.31	neutral	0.55	disease	0.46	neutral	1	0.98	neutral	0.45	neutral	-2	neutral	0.33	neutral	-0.07	medium_impact	-0.77	medium_impact	0.12	medium_impact	0.44	0.8	24.9	36.4	0.45	N	0.97	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9357	9357	A	G	MI.6956	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	151	51	T	A	Aca/Gca	-8.89	0	0	benign	0	neutral	0.26	neutral	2.34	neutral	0.35	neutral	-0.24	neutral_impact	-0.48	0.7	neutral	0.89	neutral	0.11	3.67	deleterious	0.21	0.45	0.09	neutral	0.3	neutral	0.38	neutral	0.41	neutral	2	0.74	neutral	0.63	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	-0.07	medium_impact	-1.61	low_impact	0.44	0.8	20.69	20.98	0.41	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9357	9357	A	C	MI.6957	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	151	51	T	P	Aca/Cca	-8.89	0	0	benign	0.15	neutral	0.05	neutral	2.27	neutral	-1.88	neutral	-2.04	low_impact	1.04	0.58	damaging	0.14	damaging	1.55	13.56	neutral	0.07	0.35	0.34	neutral	0.78	disease	0.53	disease	0.75	disease	5	0.94	neutral	0.45	neutral	-6	neutral	0.26	neutral	-0.14	medium_impact	-0.54	medium_impact	-0.25	medium_impact	0.36	0.8	20.69	20.98	0.29	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9357	9357	A	T	MI.6958	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	151	51	T	S	Aca/Tca	-8.89	0	0	benign	0.03	neutral	0.53	neutral	2.32	neutral	-0.07	neutral	-0.92	neutral_impact	0.32	0.68	neutral	0.49	neutral	-0.06	2.07	deleterious	0.34	0.5	0.16	neutral	0.26	neutral	0.27	neutral	0.44	neutral	1	0.43	neutral	0.75	deleterious	-6	neutral	0.11	neutral	0.6	medium_impact	0.22	medium_impact	-0.9	medium_impact	0.57	0.8	20.69	20.98	0.35	N	0.19	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9358	9358	C	A	MI.6959	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	152	51	T	K	aCa/aAa	-4.5	0	0	benign	0.05	neutral	0.07	neutral	2.29	neutral	-0.95	neutral	-1.61	low_impact	1.73	0.63	neutral	0.16	damaging	2.42	18.92	deleterious	0.07	0.35	0.19	neutral	0.61	disease	0.61	disease	0.72	disease	4	0.93	neutral	0.51	deleterious	-6	neutral	0.17	neutral	0.37	medium_impact	-0.45	medium_impact	0.37	medium_impact	0.55	0.8	20.69	20.98	0.35	N	0.57	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8854	8854	G	A	MI.696	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	328	110	A	T	Gcg/Acg	1.29	0.99	0.01	benign	0.01	deleterious	0.04	neutral	4.36	neutral	-0.89	neutral	-1.75	neutral_impact	0.55	0.96	neutral	0.83	neutral	2.13	17.05	deleterious	0.46	0.65	0.51	disease	0.59	disease	0.28	neutral	0.41	neutral	2	0.96	neutral	0.52	deleterious	-2	neutral	0.22	neutral	1.14	medium_impact	-0.49	medium_impact	-0.63	medium_impact	0.70	0.9	22.12	15.91	0.47	N	0.80	polymorphism	0.66	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9358	9358	C	T	MI.6960	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	152	51	T	M	aCa/aTa	-4.5	0	0	benign	0	neutral	0.25	neutral	2.33	neutral	0.25	neutral	1.34	neutral_impact	-0.2	0.71	neutral	0.98	neutral	0.60	8.18	deleterious	0.12	0.4	0.19	neutral	0.33	neutral	0.28	neutral	0.45	neutral	1	0.75	neutral	0.63	deleterious	-6	neutral	0.11	neutral	2.05	high_impact	-0.08	medium_impact	-1.36	low_impact	0.56	0.8	20.69	20.98	0.46	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9360	9360	C	G	MI.6961	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	154	52	L	V	Cta/Gta	-9.59	0	0	benign	0.1	neutral	0.45	neutral	2.42	neutral	-0.2	neutral	-1.69	medium_impact	2.17	0.6	neutral	0.07	damaging	1.69	14.36	neutral	0.23	0.45	0.15	neutral	0.44	neutral	0.36	neutral	0.44	neutral	1	0.48	neutral	0.68	deleterious	-3	neutral	0.18	neutral	0.06	medium_impact	0.14	medium_impact	0.76	medium_impact	0.55	0.8	20.31	27.93	0.28	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9360	9360	C	A	MI.6962	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	154	52	L	M	Cta/Ata	-9.59	0	0	benign	0.1	neutral	0.32	neutral	2.36	neutral	-1.76	neutral	-0.87	low_impact	1.84	0.66	neutral	0.26	damaging	0.93	10.24	neutral	0.24	0.45	0.27	neutral	0.37	neutral	0.34	neutral	0.44	neutral	1	0.64	neutral	0.61	deleterious	-6	neutral	0.19	neutral	0.06	medium_impact	0.01	medium_impact	0.47	medium_impact	0.41	0.8	20.31	27.93	0.4	N	0.85	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9361	9361	T	G	MI.6963	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	155	52	L	R	cTa/cGa	-1.26	0	0	possibly_damaging	0.78	neutral	0.05	neutral	2.35	neutral	-2.5	deleterious	-4.66	high_impact	3.87	0.6	neutral	0.02	damaging	3.99	23.60	deleterious	0.02	0.35	0.36	neutral	0.88	disease	0.68	disease	0.75	disease	5	0.97	neutral	0.14	neutral	1	deleterious	0.72	deleterious	-1.4	low_impact	-0.54	medium_impact	2.29	high_impact	0.24	0.8	20.31	27.93	0.34	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9361	9361	T	C	MI.6964	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	155	52	L	P	cTa/cCa	-1.26	0	0	probably_damaging	0.94	deleterious	0.03	neutral	2.33	deleterious	-3.21	deleterious	-5.35	high_impact	3.52	0.59	damaging	0.01	damaging	3.80	23.40	deleterious	0.02	0.35	0.46	neutral	0.86	disease	0.68	disease	0.74	disease	5	0.99	deleterious	0.05	neutral	6	deleterious	0.82	deleterious	-2.03	low_impact	-0.67	medium_impact	1.97	medium_impact	0.27	0.8	20.31	27.93	0.25	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9361	9361	T	A	MI.6965	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	155	52	L	Q	cTa/cAa	-1.26	0	0	possibly_damaging	0.78	deleterious	0.04	neutral	2.33	neutral	-2.6	deleterious	-4.46	high_impact	3.87	0.6	neutral	0.02	damaging	4.00	23.60	deleterious	0.04	0.35	0.37	neutral	0.74	disease	0.55	disease	0.66	disease	3	0.97	neutral	0.13	neutral	5	deleterious	0.66	deleterious	-1.4	low_impact	-0.6	medium_impact	2.29	high_impact	0.31	0.8	20.31	27.93	0.35	N	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9363	9363	A	T	MI.6966	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	157	53	T	S	Acc/Tcc	-6.58	0	0	probably_damaging	0.98	neutral	0.41	neutral	2.49	neutral	-0.51	deleterious	-3.32	low_impact	1.48	0.53	damaging	0.11	damaging	1.28	12.18	neutral	0.36	0.5	0.18	neutral	0.44	neutral	0.4	neutral	0.43	neutral	1	0.97	neutral	0.22	neutral	-2	neutral	0.67	deleterious	-2.51	low_impact	0.1	medium_impact	0.14	medium_impact	0.61	0.8	76.63	10.86	0.27	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9363	9363	A	G	MI.6967	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	157	53	T	A	Acc/Gcc	-6.58	0	0	probably_damaging	0.98	neutral	0.34	neutral	2.48	neutral	-0.65	deleterious	-4.07	medium_impact	3.04	0.48	damaging	0.06	damaging	2.95	22.10	deleterious	0.21	0.45	0.12	neutral	0.61	disease	0.51	disease	0.47	neutral	1	0.98	neutral	0.18	neutral	1	deleterious	0.67	deleterious	-2.51	low_impact	0.03	medium_impact	1.54	medium_impact	0.46	0.8	76.63	10.86	0.31	N	0.44	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9363	9363	A	C	MI.6968	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	157	53	T	P	Acc/Ccc	-6.58	0	0	probably_damaging	1	neutral	0.06	neutral	2.44	neutral	-2.61	deleterious	-5.08	high_impact	3.6	0.46	damaging	0.03	damaging	3.29	22.80	deleterious	0.05	0.35	0.44	neutral	0.84	disease	0.72	disease	0.76	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.49	medium_impact	2.04	high_impact	0.35	0.8	76.63	10.86	0.32	N	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9364	9364	C	T	MI.6969	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	158	53	T	I	aCc/aTc	3.6	0.99	0	probably_damaging	1	neutral	0.55	neutral	2.55	neutral	-0.63	deleterious	-4.58	low_impact	1.3	0.56	damaging	0.15	damaging	3.70	23.30	deleterious	0.1	0.4	0.14	neutral	0.68	disease	0.4	neutral	0.47	neutral	1	1	deleterious	0.28	neutral	-2	neutral	0.70	deleterious	-3.78	low_impact	0.24	medium_impact	-0.02	medium_impact	0.65	0.8	76.63	10.86	0.31	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8854	8854	G	T	MI.697	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	328	110	A	S	Gcg/Tcg	1.29	0.99	0.01	benign	0.19	deleterious	0.03	neutral	4.3	neutral	-1.32	neutral	-1.78	neutral_impact	0.34	0.89	neutral	0.74	neutral	1.86	15.37	deleterious	0.33	0.65	0.61	disease	0.66	disease	0.47	neutral	0.49	neutral	0	0.97	neutral	0.42	neutral	-2	neutral	0.34	neutral	-0.16	medium_impact	-0.56	medium_impact	-0.81	medium_impact	0.84	0.9	22.12	15.91	0.43	N	0.95	polymorphism	0.82	0.02	rs386829055	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9364	9364	C	A	MI.6970	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	158	53	T	N	aCc/aAc	3.6	0.99	0	probably_damaging	1	neutral	0.1	neutral	2.44	neutral	-2.19	deleterious	-4.27	medium_impact	2.9	0.5	damaging	0.03	damaging	3.58	23.20	deleterious	0.23	0.45	0.33	neutral	0.78	disease	0.6	disease	0.69	disease	4	1	deleterious	0.05	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	-0.35	medium_impact	1.42	medium_impact	0.52	0.8	76.63	10.86	0.38	N	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9364	9364	C	G	MI.6971	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	158	53	T	S	aCc/aGc	3.6	0.99	0	probably_damaging	0.98	neutral	0.41	neutral	2.49	neutral	-0.51	deleterious	-3.32	low_impact	1.48	0.53	damaging	0.11	damaging	1.47	13.14	neutral	0.36	0.5	0.18	neutral	0.44	neutral	0.4	neutral	0.43	neutral	1	0.97	neutral	0.22	neutral	-2	neutral	0.67	deleterious	-2.51	low_impact	0.1	medium_impact	0.14	medium_impact	0.61	0.8	76.63	10.86	0.39	N	0.77	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9366	9366	A	G	MI.6972	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	160	54	M	V	Ata/Gta	-20	0	0	benign	0.01	neutral	0.51	neutral	2.53	neutral	-0.21	neutral	-2.44	medium_impact	2.79	0.62	neutral	0.64	neutral	0.77	9.26	deleterious	0.26	0.45	0.13	neutral	0.62	disease	0.51	disease	0.41	neutral	2	0.48	neutral	0.75	deleterious	-3	neutral	0.18	neutral	1.07	medium_impact	0.2	medium_impact	1.32	medium_impact	0.32	0.8	34.48	14.35	0.39	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9366	9366	A	T	MI.6973	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	160	54	M	L	Ata/Tta	-20	0	0	benign	0	neutral	1	neutral	2.66	neutral	1.28	neutral	-1.92	low_impact	1.38	0.6	damaging	0.69	neutral	1.44	13.02	neutral	0.28	0.45	0.13	neutral	0.66	disease	0.58	disease	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.19	neutral	2.05	high_impact	1.9	high_impact	0.05	medium_impact	0.30	0.8	34.48	14.35	0.37	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9366	9366	A	C	MI.6974	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	160	54	M	L	Ata/Cta	-20	0	0	benign	0	neutral	1	neutral	2.66	neutral	1.28	neutral	-1.92	low_impact	1.38	0.6	damaging	0.69	neutral	1.26	12.06	neutral	0.28	0.45	0.13	neutral	0.66	disease	0.58	disease	0.44	neutral	1	0	neutral	1	deleterious	-6	neutral	0.19	neutral	2.05	high_impact	1.9	high_impact	0.05	medium_impact	0.30	0.8	34.48	14.35	0.37	N	0.23	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9367	9367	T	C	MI.6975	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	161	54	M	T	aTa/aCa	3.83	0.99	0	benign	0.03	neutral	0.72	neutral	2.5	neutral	-1.47	deleterious	-3.26	medium_impact	3.16	0.68	neutral	0.61	neutral	0.95	10.37	neutral	0.1	0.4	0.21	neutral	0.71	disease	0.53	disease	0.5	neutral	0	0.23	neutral	0.85	deleterious	-3	neutral	0.22	neutral	0.6	medium_impact	0.43	medium_impact	1.65	medium_impact	0.12	0.8	34.48	14.35	0.49	N	0.88	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9367	9367	T	A	MI.6976	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	161	54	M	K	aTa/aAa	3.83	0.99	0	benign	0.01	neutral	0.28	neutral	2.46	neutral	-2.5	deleterious	-3.79	medium_impact	3.4	0.65	neutral	0.43	neutral	1.96	15.96	deleterious	0.03	0.35	0.25	neutral	0.84	disease	0.71	disease	0.74	disease	5	0.71	neutral	0.64	deleterious	-3	neutral	0.26	neutral	1.07	medium_impact	-0.04	medium_impact	1.86	medium_impact	0.17	0.8	34.48	14.35	0.54	P	0.95	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9368	9368	A	C	MI.6977	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	162	54	M	I	atA/atC	5.91	1	0	benign	0.01	neutral	0.62	neutral	2.52	neutral	-0.29	deleterious	-2.53	medium_impact	2.63	0.68	neutral	0.63	neutral	1.30	12.29	neutral	0.27	0.45	0.19	neutral	0.68	disease	0.58	disease	0.5	disease	0	0.36	neutral	0.81	deleterious	-3	neutral	0.22	neutral	1.07	medium_impact	0.31	medium_impact	1.17	medium_impact	0.36	0.8	34.48	14.35	0.56	P	0.82	disease_causing	1	0.08	rs386829076	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9368	9368	A	T	MI.6978	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	162	54	M	I	atA/atT	5.91	1	0	benign	0.01	neutral	0.62	neutral	2.52	neutral	-0.29	deleterious	-2.53	medium_impact	2.63	0.68	neutral	0.63	neutral	1.40	12.81	neutral	0.27	0.45	0.19	neutral	0.68	disease	0.58	disease	0.5	disease	0	0.36	neutral	0.81	deleterious	-3	neutral	0.22	neutral	1.07	medium_impact	0.31	medium_impact	1.17	medium_impact	0.36	0.8	34.48	14.35	0.56	P	0.82	disease_causing	1	0.08	rs386829076	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9369	9369	T	A	MI.6979	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	163	55	Y	N	Tac/Aac	0.13	0	0	benign	0.1	neutral	0.28	neutral	2.27	neutral	-1.81	deleterious	-4.92	medium_impact	3.14	0.65	neutral	0.4	neutral	1.99	16.12	deleterious	0.11	0.4	0.25	neutral	0.65	disease	0.48	neutral	0.49	neutral	0	0.68	neutral	0.59	deleterious	-3	neutral	0.22	neutral	0.06	medium_impact	-0.04	medium_impact	1.63	medium_impact	0.31	0.8	26.82	26.66	0.45	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8855	8855	C	T	MI.698	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	329	110	A	V	gCg/gTg	0.82	0.99	0	benign	0.19	deleterious	0.04	neutral	4.42	neutral	1.18	neutral	-1.15	neutral_impact	0.04	0.87	neutral	0.59	neutral	2.53	19.64	deleterious	0.36	0.65	0.31	neutral	0.73	disease	0.51	disease	0.42	neutral	2	0.95	neutral	0.43	neutral	-2	neutral	0.33	neutral	-0.16	medium_impact	-0.49	medium_impact	-1.06	low_impact	0.72	0.9	22.12	15.91	0.43	N	0.75	polymorphism	0.79	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9369	9369	T	G	MI.6980	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	163	55	Y	D	Tac/Gac	0.13	0	0	benign	0.13	neutral	0.16	neutral	2.26	neutral	-2.48	deleterious	-5.34	medium_impact	3.14	0.66	neutral	0.35	neutral	1.98	16.11	deleterious	0.05	0.35	0.19	neutral	0.69	disease	0.58	disease	0.7	disease	4	0.82	neutral	0.52	deleterious	-3	neutral	0.33	neutral	-0.07	medium_impact	-0.22	medium_impact	1.63	medium_impact	0.28	0.8	26.82	26.66	0.39	N	0.95	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9369	9369	T	C	MI.6981	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	163	55	Y	H	Tac/Cac	0.13	0	0	benign	0	neutral	0.33	neutral	2.26	neutral	-2.19	deleterious	-3.15	medium_impact	3.14	0.71	neutral	0.43	neutral	1.41	12.86	neutral	0.16	0.45	0.25	neutral	0.5	disease	0.56	disease	0.65	disease	3	0.67	neutral	0.67	deleterious	-3	neutral	0.15	neutral	2.05	high_impact	0.02	medium_impact	1.63	medium_impact	0.34	0.8	26.82	26.66	0.44	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9370	9370	A	T	MI.6982	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	164	55	Y	F	tAc/tTc	0.13	0	0	benign	0	neutral	0.86	neutral	2.39	neutral	1.08	neutral	-0.83	neutral_impact	-0.15	0.79	neutral	0.93	neutral	-0.18	1.19	neutral	0.28	0.45	0.11	neutral	0.13	neutral	0.29	neutral	0.21	neutral	6	0.14	neutral	0.93	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.64	medium_impact	-1.32	low_impact	0.42	0.8	26.82	26.66	0.37	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9370	9370	A	G	MI.6983	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	164	55	Y	C	tAc/tGc	0.13	0	0	possibly_damaging	0.58	neutral	0.12	neutral	2.26	neutral	-2.15	deleterious	-3.98	medium_impact	2.34	0.82	neutral	0.57	neutral	3.09	22.50	deleterious	0.06	0.35	0.37	neutral	0.72	disease	0.43	neutral	0.52	disease	0	0.88	neutral	0.27	neutral	0	NA	0.58	deleterious	-1.01	low_impact	-0.3	medium_impact	0.92	medium_impact	0.13	0.8	26.82	26.66	0.35	N	0.57	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9370	9370	A	C	MI.6984	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	164	55	Y	S	tAc/tCc	0.13	0	0	benign	0.08	neutral	0.42	neutral	2.31	neutral	-0.56	deleterious	-4.4	low_impact	1.7	0.71	neutral	0.6	neutral	1.69	14.35	neutral	0.07	0.35	0.14	neutral	0.53	disease	0.47	neutral	0.46	neutral	1	0.53	neutral	0.67	deleterious	-6	neutral	0.23	neutral	0.16	medium_impact	0.11	medium_impact	0.34	medium_impact	0.37	0.8	26.82	26.66	0.37	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9372	9372	C	G	MI.6985	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	166	56	Q	E	Caa/Gaa	-7.28	0	0	possibly_damaging	0.84	neutral	0.07	neutral	2.5	neutral	-1.37	deleterious	-2.66	high_impact	3.52	0.67	neutral	0.02	damaging	2.94	22.00	deleterious	0.28	0.45	0.13	neutral	0.67	disease	0.55	disease	0.63	disease	3	0.96	neutral	0.12	neutral	1	deleterious	0.66	deleterious	-1.57	low_impact	-0.45	medium_impact	1.97	medium_impact	0.51	0.8	74.71	11.45	0.3	N	0.95	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9372	9372	C	A	MI.6986	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	166	56	Q	K	Caa/Aaa	-7.28	0	0	probably_damaging	0.92	neutral	0.29	neutral	2.5	neutral	-1.39	deleterious	-3.55	medium_impact	2.89	0.63	neutral	0.02	damaging	3.94	23.50	deleterious	0.19	0.45	0.13	neutral	0.68	disease	0.58	disease	0.6	disease	2	0.94	neutral	0.19	neutral	1	deleterious	0.64	deleterious	-1.9	low_impact	-0.03	medium_impact	1.41	medium_impact	0.39	0.8	74.71	11.45	0.27	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9373	9373	A	C	MI.6987	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	167	56	Q	P	cAa/cCa	4.52	1	0	probably_damaging	0.98	neutral	0.06	neutral	2.49	neutral	-1.43	deleterious	-5.37	medium_impact	3.31	0.62	neutral	0.05	damaging	3.24	22.80	deleterious	0.04	0.35	0.34	neutral	0.84	disease	0.64	disease	0.72	disease	4	0.99	deleterious	0.04	neutral	1	deleterious	0.80	deleterious	-2.51	low_impact	-0.49	medium_impact	1.78	medium_impact	0.34	0.8	74.71	11.45	0.41	N	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9373	9373	A	T	MI.6988	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	167	56	Q	L	cAa/cTa	4.52	1	0	probably_damaging	0.92	neutral	0.59	neutral	2.64	neutral	0.46	deleterious	-6.3	low_impact	1.3	0.5	damaging	0.06	damaging	3.68	23.30	deleterious	0.08	0.35	0.15	neutral	0.64	disease	0.34	neutral	0.44	neutral	1	0.91	neutral	0.34	neutral	-2	neutral	0.68	deleterious	-1.9	low_impact	0.28	medium_impact	-0.02	medium_impact	0.16	0.8	74.71	11.45	0.34	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9373	9373	A	G	MI.6989	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	167	56	Q	R	cAa/cGa	4.52	1	0	probably_damaging	0.95	neutral	0.31	neutral	2.51	neutral	-1.1	deleterious	-3.56	medium_impact	2.97	0.68	neutral	0.03	damaging	3.35	22.90	deleterious	0.19	0.45	0.19	neutral	0.7	disease	0.57	disease	0.65	disease	3	0.96	neutral	0.18	neutral	1	deleterious	0.70	deleterious	-2.11	low_impact	-0.01	medium_impact	1.48	medium_impact	0.15	0.8	74.71	11.45	0.42	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8855	8855	C	A	MI.699	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	329	110	A	E	gCg/gAg	0.82	0.99	0	possibly_damaging	0.48	deleterious	0	neutral	4.27	deleterious	-3.02	deleterious	-3.27	low_impact	1.7	0.84	neutral	0.46	neutral	2.85	21.60	deleterious	0.15	0.65	0.82	disease	0.88	disease	0.62	disease	0.76	disease	5	1	deleterious	0.26	neutral	1	deleterious	0.59	deleterious	-0.72	medium_impact	-1.4	low_impact	0.36	medium_impact	0.79	0.9	22.12	15.91	0.34	N	0.99	polymorphism	0.68	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9374	9374	A	C	MI.6990	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	168	56	Q	H	caA/caC	8.69	1	0	probably_damaging	0.99	neutral	0.15	neutral	2.47	neutral	-2.19	deleterious	-4.42	high_impact	3.52	0.63	neutral	0.03	damaging	3.44	23.00	deleterious	0.2	0.45	0.31	neutral	0.64	disease	0.48	neutral	0.51	disease	0	0.99	deleterious	0.08	neutral	2	deleterious	0.74	deleterious	-2.81	low_impact	-0.24	medium_impact	1.97	medium_impact	0.46	0.8	74.71	11.45	0.54	P	0.98	polymorphism	1	0.24	rs386829077	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9374	9374	A	T	MI.6991	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	168	56	Q	H	caA/caT	8.69	1	0	probably_damaging	0.99	neutral	0.15	neutral	2.47	neutral	-2.19	deleterious	-4.42	high_impact	3.52	0.63	neutral	0.03	damaging	3.48	23.10	deleterious	0.2	0.45	0.31	neutral	0.64	disease	0.48	neutral	0.51	disease	0	0.99	deleterious	0.08	neutral	2	deleterious	0.74	deleterious	-2.81	low_impact	-0.24	medium_impact	1.97	medium_impact	0.46	0.8	74.71	11.45	0.55	P	0.98	polymorphism	1	0.24	rs386829077	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9375	9375	T	C	MI.6992	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	169	57	W	R	Tga/Cga	2.67	1	0	probably_damaging	1	neutral	0.62	neutral	1.08	deleterious	-6.27	deleterious	-12.91	high_impact	4.08	0.72	neutral	0.03	damaging	3.49	23.10	deleterious	0.03	0.35	0.2	neutral	0.8	disease	0.82	disease	0.73	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.31	medium_impact	2.47	high_impact	0.07	0.8	74.33	11.3	0.44	N	0.99	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9375	9375	T	G	MI.6993	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	169	57	W	G	Tga/Gga	2.67	1	0	probably_damaging	1	neutral	0.36	neutral	1.08	deleterious	-6.23	deleterious	-11.99	high_impact	4.63	0.61	neutral	0.02	damaging	3.78	23.40	deleterious	0.04	0.35	0.29	neutral	0.77	disease	0.78	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	0.05	medium_impact	2.97	high_impact	0.07	0.8	74.33	11.3	0.49	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9376	9376	G	T	MI.6994	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	170	57	W	L	tGa/tTa	5.91	1	0	probably_damaging	1	neutral	0.7	neutral	1.12	deleterious	-4.94	deleterious	-11.99	high_impact	4.63	0.61	neutral	0.02	damaging	4.15	23.80	deleterious	0.06	0.35	0.23	neutral	0.73	disease	0.77	disease	0.73	disease	5	1	deleterious	0.35	neutral	2	deleterious	0.74	deleterious	-3.78	low_impact	0.4	medium_impact	2.97	high_impact	0.06	0.8	74.33	11.3	0.5	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9376	9376	G	C	MI.6995	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	170	57	W	S	tGa/tCa	5.91	1	0	probably_damaging	1	neutral	0.46	neutral	1.08	deleterious	-6.14	deleterious	-12.91	high_impact	4.63	0.65	neutral	0.02	damaging	3.89	23.50	deleterious	0.04	0.35	0.18	neutral	0.84	disease	0.77	disease	0.75	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	0.15	medium_impact	2.97	high_impact	0.08	0.8	74.33	11.3	0.46	N	0.97	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9377	9377	A	T	MI.6996	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	171	57	W	C	tgA/tgT	7.53	1	0.08	probably_damaging	1	neutral	0.17	neutral	1.06	deleterious	-7.73	deleterious	-11.99	high_impact	4.63	0.67	neutral	0.02	damaging	4.01	23.60	deleterious	0.04	0.35	0.58	disease	0.83	disease	0.8	disease	0.78	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.2	medium_impact	2.97	high_impact	0.10	0.8	74.33	11.3	0.52	N	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9377	9377	A	C	MI.6997	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	171	57	W	C	tgA/tgC	7.53	1	0.08	probably_damaging	1	neutral	0.17	neutral	1.06	deleterious	-7.73	deleterious	-11.99	high_impact	4.63	0.67	neutral	0.02	damaging	4.03	23.60	deleterious	0.04	0.35	0.58	disease	0.83	disease	0.8	disease	0.78	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.2	medium_impact	2.97	high_impact	0.10	0.8	74.33	11.3	0.51	N	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9378	9378	T	G	MI.6998	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	172	58	W	G	Tgg/Ggg	1.05	1	0	probably_damaging	0.99	neutral	0.32	neutral	2.42	neutral	-2.63	deleterious	-11.99	medium_impact	3.15	0.61	neutral	0.36	neutral	3.86	23.50	deleterious	0.05	0.35	0.13	neutral	0.74	disease	0.71	disease	0.67	disease	3	0.99	deleterious	0.17	neutral	1	deleterious	0.71	deleterious	-2.81	low_impact	0.01	medium_impact	1.64	medium_impact	0.18	0.8	74.71	11.62	0.39	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9378	9378	T	C	MI.6999	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	172	58	W	R	Tgg/Cgg	1.05	1	0	probably_damaging	1	neutral	0.4	neutral	2.45	neutral	-2.54	deleterious	-12.91	high_impact	4.08	0.59	damaging	0.17	damaging	3.52	23.10	deleterious	0.03	0.35	0.14	neutral	0.79	disease	0.74	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.74	deleterious	-3.78	low_impact	0.09	medium_impact	2.47	high_impact	0.16	0.8	74.71	11.62	0.42	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8530	8530	A	G	MI.7	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	4	2	N	D	Aac/Gac	7.3	1	0	probably_damaging	0.95	deleterious	0.03	neutral	4.64	neutral	-0.68	deleterious	-3.06	low_impact	1.9	0.86	neutral	0.58	neutral	3.48	23.10	deleterious	0.84	0.85	0.4	neutral	0.27	neutral	0.12	neutral	0.46	neutral	1	0.99	deleterious	0.04	neutral	2	deleterious	0.64	deleterious	-1.97	low_impact	-0.56	medium_impact	0.53	medium_impact	0.39	0.9	41.59	7.23	0.57	P	0.96	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8557	8557	G	T	MI.70	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	31	11	A	S	Gcc/Tcc	-0.8	0	0.02	benign	0.19	neutral	0.96	neutral	4.75	neutral	0.13	neutral	0.8	neutral_impact	-1.72	0.85	neutral	0.9	neutral	2.73	21.00	deleterious	0.5	0.65	0.31	neutral	0.08	neutral	0.16	neutral	0.28	neutral	4	0.12	neutral	0.89	deleterious	-6	neutral	0.20	neutral	-0.16	medium_impact	1.07	medium_impact	-2.57	low_impact	0.64	0.9	23.45	19.76	0.35	N	0.53	polymorphism	1	0.01	rs386829040	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8855	8855	C	G	MI.700	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	329	110	A	G	gCg/gGg	0.82	0.99	0	benign	0.19	neutral	0.05	neutral	4.28	neutral	-1.35	deleterious	-3.23	neutral_impact	0.23	0.9	neutral	0.54	neutral	2.04	16.44	deleterious	0.2	0.65	0.4	neutral	0.68	disease	0.45	neutral	0.51	disease	0	0.94	neutral	0.43	neutral	-6	neutral	0.34	neutral	-0.16	medium_impact	-0.43	medium_impact	-0.9	medium_impact	0.76	0.9	22.12	15.91	0.47	N	0.86	polymorphism	0.83	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9379	9379	G	C	MI.7000	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	173	58	W	S	tGg/tCg	7.53	1	0	probably_damaging	1	neutral	0.41	neutral	2.45	neutral	-1.71	deleterious	-12.91	high_impact	3.54	0.56	damaging	0.34	neutral	3.95	23.60	deleterious	0.05	0.35	0.14	neutral	0.81	disease	0.69	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.1	medium_impact	1.99	medium_impact	0.18	0.8	74.71	11.62	0.44	N	0.97	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9379	9379	G	T	MI.7001	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	173	58	W	L	tGg/tTg	7.53	1	0	probably_damaging	0.99	neutral	0.68	neutral	2.53	neutral	-0.39	deleterious	-11.99	medium_impact	3.11	0.53	damaging	0.37	neutral	4.15	23.80	deleterious	0.07	0.35	0.12	neutral	0.73	disease	0.68	disease	0.66	disease	3	0.99	deleterious	0.35	neutral	1	deleterious	0.72	deleterious	-2.81	low_impact	0.38	medium_impact	1.61	medium_impact	0.18	0.8	74.71	11.62	0.48	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9380	9380	G	T	MI.7002	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	174	58	W	C	tgG/tgT	6.14	1	0.02	probably_damaging	1	neutral	0.18	neutral	2.39	deleterious	-3.3	deleterious	-11.99	high_impact	4.43	0.61	neutral	0.26	damaging	4.07	23.70	deleterious	0.04	0.35	0.4	neutral	0.83	disease	0.7	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	-0.18	medium_impact	2.79	high_impact	0.21	0.8	74.71	11.62	0.48	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9380	9380	G	C	MI.7003	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	174	58	W	C	tgG/tgC	6.14	1	0.02	probably_damaging	1	neutral	0.18	neutral	2.39	deleterious	-3.3	deleterious	-11.99	high_impact	4.43	0.61	neutral	0.26	damaging	3.92	23.50	deleterious	0.04	0.35	0.4	neutral	0.83	disease	0.7	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	-0.18	medium_impact	2.79	high_impact	0.21	0.8	74.71	11.62	0.47	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9381	9381	C	G	MI.7004	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	175	59	R	G	Cgc/Ggc	2.21	1	0	probably_damaging	1	neutral	0.33	neutral	1.77	deleterious	-4.37	deleterious	-6.45	medium_impact	2.66	0.62	neutral	0.01	damaging	4.08	23.70	deleterious	0.05	0.35	0.52	disease	0.7	disease	0.68	disease	0.55	disease	1	1	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	0.02	medium_impact	1.2	medium_impact	0.28	0.8	74.33	11.45	0.31	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9381	9381	C	T	MI.7005	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	175	59	R	C	Cgc/Tgc	2.21	1	0	probably_damaging	1	neutral	0.18	neutral	1.74	deleterious	-6.51	deleterious	-7.37	high_impact	4.37	0.65	neutral	0.01	damaging	4.94	25.00	deleterious	0.08	0.35	0.81	disease	0.85	disease	0.68	disease	0.75	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.18	medium_impact	2.73	high_impact	0.64	0.8	74.33	11.45	0.45	N	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9381	9381	C	A	MI.7006	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	175	59	R	S	Cgc/Agc	2.21	1	0	probably_damaging	1	neutral	0.41	neutral	1.8	deleterious	-3.5	deleterious	-5.53	medium_impact	1.97	0.65	neutral	0.01	damaging	4.44	24.20	deleterious	0.06	0.35	0.39	neutral	0.73	disease	0.66	disease	0.53	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.81	deleterious	-3.78	low_impact	0.1	medium_impact	0.58	medium_impact	0.32	0.8	74.33	11.45	0.29	N	0.88	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9382	9382	G	T	MI.7007	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	176	59	R	L	cGc/cTc	1.52	1	0	probably_damaging	0.99	neutral	0.68	neutral	1.78	deleterious	-3.96	deleterious	-6.45	high_impact	3.67	0.62	neutral	0.01	damaging	4.26	23.90	deleterious	0.06	0.35	0.46	neutral	0.87	disease	0.62	disease	0.71	disease	4	0.99	deleterious	0.35	neutral	2	deleterious	0.83	deleterious	-2.81	low_impact	0.38	medium_impact	2.11	high_impact	0.12	0.8	74.33	11.45	0.37	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9382	9382	G	C	MI.7008	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	176	59	R	P	cGc/cCc	1.52	1	0	probably_damaging	1	neutral	0.2	neutral	1.76	deleterious	-4.92	deleterious	-6.45	high_impact	4.02	0.59	damaging	0.02	damaging	4.14	23.80	deleterious	0.02	0.35	0.59	disease	0.85	disease	0.77	disease	0.79	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.15	medium_impact	2.42	high_impact	0.19	0.8	74.33	11.45	0.44	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9382	9382	G	A	MI.7009	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	176	59	R	H	cGc/cAc	1.52	1	0	probably_damaging	1	neutral	0.54	neutral	1.77	deleterious	-4.28	deleterious	-4.61	high_impact	4.37	0.61	neutral	0.01	damaging	4.29	24.00	deleterious	0.13	0.4	0.29	neutral	0.74	disease	0.62	disease	0.65	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	0.23	medium_impact	2.73	high_impact	0.73	0.85	74.33	11.45	0.4	N	1.00	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8857	8857	G	A	MI.701	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	331	111	G	S	Ggc/Agc	-13.06	0	0.01	benign	0.15	neutral	1	neutral	4.43	neutral	0.26	neutral	-2.1	neutral_impact	0.66	0.8	neutral	0.64	neutral	1.22	11.86	neutral	0.36	0.65	0.51	disease	0.47	neutral	0.35	neutral	0.4	neutral	2	0.15	neutral	0.93	deleterious	-6	neutral	0.27	neutral	-0.04	medium_impact	1.98	high_impact	-0.53	medium_impact	0.84	0.9	14.6	14.23	0.18	N	0.19	polymorphism	1	0.03	rs201017581	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9384	9384	G	T	MI.7010	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	178	60	D	Y	Gat/Tat	-1.03	0	0	probably_damaging	1	neutral	1	neutral	1.26	deleterious	-6.83	deleterious	-8.3	high_impact	4.54	0.62	neutral	0.02	damaging	3.90	23.50	deleterious	0.03	0.35	0.5	neutral	0.86	disease	0.71	disease	0.76	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.84	deleterious	-3.78	low_impact	1.9	high_impact	2.89	high_impact	0.10	0.8	75.1	11.32	0.34	N	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9384	9384	G	A	MI.7011	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	178	60	D	N	Gat/Aat	-1.03	0	0	probably_damaging	1	neutral	0.3	neutral	1.32	deleterious	-4.5	deleterious	-4.61	medium_impact	3.04	0.56	damaging	0.02	damaging	4.14	23.80	deleterious	0.35	0.5	0.36	neutral	0.72	disease	0.68	disease	0.63	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	-0.02	medium_impact	1.54	medium_impact	0.91	0.95	75.1	11.32	0.28	N	0.96	polymorphism	1	0.15	.	.	.	.	.	.	COSM1138428	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9384	9384	G	C	MI.7012	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	178	60	D	H	Gat/Cat	-1.03	0	0	probably_damaging	1	neutral	0.54	neutral	1.27	deleterious	-6.1	deleterious	-6.46	medium_impact	3.26	0.57	damaging	0.02	damaging	3.61	23.20	deleterious	0.05	0.35	0.53	disease	0.73	disease	0.72	disease	0.72	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.81	deleterious	-3.78	low_impact	0.23	medium_impact	1.74	medium_impact	0.54	0.8	75.1	11.32	0.21	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9385	9385	A	G	MI.7013	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	179	60	D	G	gAt/gGt	7.3	1	0	probably_damaging	1	neutral	0.33	neutral	1.3	deleterious	-4.99	deleterious	-6.46	high_impact	3.74	0.59	damaging	0.01	damaging	4.02	23.60	deleterious	0.05	0.35	0.45	neutral	0.75	disease	0.72	disease	0.72	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.02	medium_impact	2.17	high_impact	0.26	0.8	75.1	11.32	0.51	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9385	9385	A	T	MI.7014	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	179	60	D	V	gAt/gTt	7.3	1	0	probably_damaging	1	neutral	0.53	neutral	1.27	deleterious	-5.97	deleterious	-8.3	high_impact	4.54	0.56	damaging	0.02	damaging	3.83	23.40	deleterious	0.03	0.35	0.39	neutral	0.82	disease	0.7	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.22	medium_impact	2.89	high_impact	0.07	0.8	75.1	11.32	0.44	N	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9385	9385	A	C	MI.7015	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	179	60	D	A	gAt/gCt	7.3	1	0	probably_damaging	1	neutral	0.5	neutral	1.31	deleterious	-4.76	deleterious	-7.38	medium_impact	3.3	0.59	damaging	0.02	damaging	3.75	23.30	deleterious	0.04	0.35	0.32	neutral	0.76	disease	0.7	disease	0.7	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	0.19	medium_impact	1.78	medium_impact	0.22	0.8	75.1	11.32	0.41	N	0.83	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9386	9386	T	A	MI.7016	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	180	60	D	E	gaT/gaA	7.07	1	0	probably_damaging	0.98	neutral	0.27	neutral	1.37	deleterious	-3.63	deleterious	-3.69	medium_impact	3.23	0.6	neutral	0.02	damaging	3.99	23.60	deleterious	0.19	0.45	0.26	neutral	0.64	disease	0.57	disease	0.46	neutral	1	0.98	neutral	0.15	neutral	1	deleterious	0.75	deleterious	-2.51	low_impact	-0.06	medium_impact	1.71	medium_impact	0.51	0.8	75.1	11.32	0.54	P	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9386	9386	T	G	MI.7017	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	180	60	D	E	gaT/gaG	7.07	1	0	probably_damaging	0.98	neutral	0.27	neutral	1.37	deleterious	-3.63	deleterious	-3.69	medium_impact	3.23	0.6	neutral	0.02	damaging	3.81	23.40	deleterious	0.19	0.45	0.26	neutral	0.64	disease	0.57	disease	0.46	neutral	1	0.98	neutral	0.15	neutral	1	deleterious	0.75	deleterious	-2.51	low_impact	-0.06	medium_impact	1.71	medium_impact	0.51	0.8	75.1	11.32	0.53	P	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9387	9387	G	A	MI.7018	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	181	61	V	M	Gta/Ata	-2.88	0	0	benign	0.42	neutral	0.18	neutral	2	neutral	-2.5	neutral	-2.35	medium_impact	2.9	0.63	neutral	0.45	neutral	3.48	23.10	deleterious	0.17	0.45	0.21	neutral	0.5	disease	0.42	neutral	0.46	neutral	1	0.79	neutral	0.38	neutral	-3	neutral	0.43	neutral	-0.73	medium_impact	-0.18	medium_impact	1.42	medium_impact	0.97	1	72.41	10.38	0.54	N	0.69	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	G9387A	Asthenozoospermia	-	+	Reported	1	.	P	P	neutral
chrM	9387	9387	G	T	MI.7019	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	181	61	V	L	Gta/Tta	-2.88	0	0	benign	0.01	neutral	0.54	neutral	2.18	neutral	-0.68	neutral	-1.95	medium_impact	2.73	0.64	neutral	0.42	neutral	1.68	14.28	neutral	0.17	0.45	0.13	neutral	0.59	disease	0.55	disease	0.56	disease	1	0.45	neutral	0.77	deleterious	-3	neutral	0.16	neutral	1.07	medium_impact	0.23	medium_impact	1.26	medium_impact	0.68	0.85	72.41	10.38	0.31	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8857	8857	G	C	MI.702	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	331	111	G	R	Ggc/Cgc	-13.06	0	0.01	probably_damaging	0.92	neutral	0.08	neutral	4.24	neutral	-2.7	deleterious	-4.05	medium_impact	3.36	0.77	neutral	0.32	neutral	3.88	23.50	deleterious	0.13	0.65	0.79	disease	0.92	disease	0.7	disease	0.78	disease	6	0.98	neutral	0.08	neutral	1	deleterious	0.86	deleterious	-1.76	low_impact	-0.31	medium_impact	1.78	medium_impact	0.62	0.9	14.6	14.23	0.31	N	0.95	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9387	9387	G	C	MI.7020	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	181	61	V	L	Gta/Cta	-2.88	0	0	benign	0.01	neutral	0.54	neutral	2.18	neutral	-0.68	neutral	-1.95	medium_impact	2.73	0.64	neutral	0.42	neutral	1.58	13.73	neutral	0.17	0.45	0.13	neutral	0.59	disease	0.55	disease	0.56	disease	1	0.45	neutral	0.77	deleterious	-3	neutral	0.16	neutral	1.07	medium_impact	0.23	medium_impact	1.26	medium_impact	0.68	0.85	72.41	10.38	0.31	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9388	9388	T	C	MI.7021	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	182	61	V	A	gTa/gCa	-0.1	0	0	benign	0.16	neutral	0.87	neutral	1.98	neutral	-2.86	deleterious	-3.67	medium_impact	2.81	0.61	neutral	0.54	neutral	1.89	15.51	deleterious	0.09	0.35	0.14	neutral	0.57	disease	0.61	disease	0.65	disease	3	0.07	neutral	0.86	deleterious	-3	neutral	0.25	neutral	-0.17	medium_impact	0.66	medium_impact	1.34	medium_impact	0.24	0.8	72.41	10.38	0.28	N	0.87	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9388	9388	T	A	MI.7022	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	182	61	V	E	gTa/gAa	-0.1	0	0	possibly_damaging	0.5	neutral	1	neutral	1.94	deleterious	-4.65	deleterious	-5.52	high_impact	4.28	0.59	damaging	0.3	neutral	4.33	24.00	deleterious	0.02	0.35	0.27	neutral	0.83	disease	0.71	disease	0.74	disease	5	0.5	neutral	0.75	deleterious	1	deleterious	0.51	deleterious	-0.87	medium_impact	1.9	high_impact	2.65	high_impact	0.17	0.8	72.41	10.38	0.29	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9388	9388	T	G	MI.7023	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	182	61	V	G	gTa/gGa	-0.1	0	0	possibly_damaging	0.59	neutral	0.47	neutral	1.94	deleterious	-4.89	deleterious	-6.44	high_impact	3.94	0.61	neutral	0.34	neutral	3.64	23.20	deleterious	0.03	0.35	0.33	neutral	0.71	disease	0.59	disease	0.67	disease	3	0.58	neutral	0.44	neutral	1	deleterious	0.64	deleterious	-1.02	low_impact	0.16	medium_impact	2.35	high_impact	0.24	0.8	72.41	10.38	0.34	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9390	9390	A	T	MI.7024	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	184	62	T	S	Aca/Tca	-8.66	0	0	benign	0	neutral	0.87	neutral	2.35	neutral	0.43	neutral	-1.63	low_impact	0.94	0.72	neutral	0.75	neutral	0.09	3.54	deleterious	0.31	0.45	0.1	neutral	0.15	neutral	0.19	neutral	0.3	neutral	4	0.12	neutral	0.94	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	0.66	medium_impact	-0.34	medium_impact	0.73	0.85	15.33	13.99	0.41	N	0.10	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9390	9390	A	G	MI.7025	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	184	62	T	A	Aca/Gca	-8.66	0	0	benign	0	neutral	0.92	neutral	2.36	neutral	0.62	neutral	-0.8	low_impact	1.5	0.7	neutral	0.77	neutral	0.38	6.43	deleterious	0.23	0.45	0.11	neutral	0.25	neutral	0.38	neutral	0.42	neutral	2	0.08	neutral	0.96	deleterious	-6	neutral	0.11	neutral	2.05	high_impact	0.8	medium_impact	0.16	medium_impact	0.37	0.8	15.33	13.99	0.34	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9390	9390	A	C	MI.7026	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	184	62	T	P	Aca/Cca	-8.66	0	0	benign	0	neutral	0.37	neutral	2.27	neutral	-1.87	deleterious	-2.64	medium_impact	2.44	0.56	damaging	0.36	neutral	1.49	13.25	neutral	0.05	0.35	0.3	neutral	0.64	disease	0.61	disease	0.72	disease	4	0.63	neutral	0.69	deleterious	-3	neutral	0.23	neutral	2.05	high_impact	0.06	medium_impact	1	medium_impact	0.37	0.8	15.33	13.99	0.34	N	0.23	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9391	9391	C	T	MI.7027	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	185	62	T	M	aCa/aTa	-1.26	0	0	benign	0	neutral	0.25	neutral	2.3	neutral	-0.53	neutral	-0.63	low_impact	1.89	0.76	neutral	0.87	neutral	1.91	15.65	deleterious	0.1	0.4	0.2	neutral	0.25	neutral	0.39	neutral	0.43	neutral	1	0.75	neutral	0.63	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	-0.08	medium_impact	0.51	medium_impact	0.60	0.8	15.33	13.99	0.49	N	0.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9391	9391	C	A	MI.7028	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	185	62	T	K	aCa/aAa	-1.26	0	0	benign	0	neutral	0.86	neutral	2.29	neutral	-0.76	deleterious	-2.6	medium_impact	2.24	0.67	neutral	0.49	neutral	2.45	19.14	deleterious	0.07	0.35	0.14	neutral	0.41	neutral	0.59	disease	0.46	neutral	1	0.13	neutral	0.93	deleterious	-3	neutral	0.15	neutral	2.05	high_impact	0.64	medium_impact	0.83	medium_impact	0.43	0.8	15.33	13.99	0.3	N	0.22	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9393	9393	C	T	MI.7029	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	187	63	R	W	Cga/Tga	-10.51	0	0	probably_damaging	1	neutral	0.09	neutral	2.31	deleterious	-4.97	deleterious	-7.38	high_impact	4.34	0.56	damaging	0.03	damaging	5.14	25.40	deleterious	0.06	0.35	0.69	disease	0.88	disease	0.64	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.38	medium_impact	2.71	high_impact	0.80	0.85	73.56	11.64	0.33	N	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8857	8857	G	T	MI.703	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	331	111	G	C	Ggc/Tgc	-13.06	0	0.01	probably_damaging	0.98	neutral	0.07	neutral	4.29	neutral	-1.21	deleterious	-4.05	medium_impact	2	0.74	neutral	0.32	neutral	4.09	23.70	deleterious	0.18	0.65	0.76	disease	0.88	disease	0.59	disease	0.73	disease	5	0.99	deleterious	0.05	neutral	1	deleterious	0.83	deleterious	-2.36	low_impact	-0.34	medium_impact	0.62	medium_impact	0.70	0.9	14.6	14.23	0.29	N	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9393	9393	C	G	MI.7030	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	187	63	R	G	Cga/Gga	-10.51	0	0	probably_damaging	1	neutral	0.41	neutral	2.35	neutral	-1.77	deleterious	-6.46	medium_impact	3.1	0.57	damaging	0.04	damaging	4.18	23.80	deleterious	0.05	0.35	0.26	neutral	0.75	disease	0.64	disease	0.66	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.1	medium_impact	1.6	medium_impact	0.20	0.8	73.56	11.64	0.22	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9394	9394	G	C	MI.7031	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	188	63	R	P	cGa/cCa	2.9	0.98	0	probably_damaging	1	neutral	0.26	neutral	2.34	neutral	-2.58	deleterious	-6.46	high_impact	4.34	0.55	damaging	0.03	damaging	4.17	23.80	deleterious	0.02	0.35	0.39	neutral	0.86	disease	0.74	disease	0.76	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.07	medium_impact	2.71	high_impact	0.11	0.8	73.56	11.64	0.49	P	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9394	9394	G	A	MI.7032	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	188	63	R	Q	cGa/cAa	2.9	0.98	0	probably_damaging	0.99	neutral	0.55	neutral	2.34	neutral	-0.86	deleterious	-3.69	high_impact	3.79	0.64	neutral	0.03	damaging	4.46	24.20	deleterious	0.14	0.4	0.21	neutral	0.76	disease	0.63	disease	0.66	disease	3	0.99	deleterious	0.28	neutral	2	deleterious	0.74	deleterious	-2.81	low_impact	0.24	medium_impact	2.21	high_impact	0.66	0.8	73.56	11.64	0.44	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9394	9394	G	T	MI.7033	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	188	63	R	L	cGa/cTa	2.9	0.98	0	probably_damaging	0.99	neutral	0.55	neutral	2.41	neutral	-1.89	deleterious	-6.46	medium_impact	3.19	0.61	neutral	0.03	damaging	4.25	23.90	deleterious	0.06	0.35	0.2	neutral	0.87	disease	0.61	disease	0.71	disease	4	0.99	deleterious	0.28	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	0.24	medium_impact	1.68	medium_impact	0.08	0.8	73.56	11.64	0.36	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9396	9396	G	C	MI.7034	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	190	64	E	Q	Gaa/Caa	-0.1	0.9	0	probably_damaging	0.99	neutral	0.32	neutral	1.45	deleterious	-4.5	deleterious	-2.8	high_impact	4.28	0.56	damaging	0.05	damaging	3.32	22.90	deleterious	0.14	0.4	0.28	neutral	0.58	disease	0.59	disease	0.64	disease	3	0.99	deleterious	0.17	neutral	2	deleterious	0.75	deleterious	-2.81	low_impact	0.01	medium_impact	2.65	high_impact	0.77	0.85	73.95	11.56	0.36	N	0.87	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9396	9396	G	A	MI.7035	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	190	64	E	K	Gaa/Aaa	-0.1	0.9	0	probably_damaging	1	neutral	0.25	neutral	1.47	deleterious	-4.04	deleterious	-3.72	high_impact	3.58	0.51	damaging	0.04	damaging	4.40	24.10	deleterious	0.07	0.35	0.22	neutral	0.66	disease	0.68	disease	0.67	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	-0.08	medium_impact	2.03	high_impact	0.75	0.85	73.95	11.56	0.37	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9397	9397	A	C	MI.7036	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	191	64	E	A	gAa/gCa	9.15	1	0	probably_damaging	1	neutral	0.59	neutral	1.46	deleterious	-4.35	deleterious	-5.6	high_impact	3.93	0.52	damaging	0.08	damaging	3.42	23.00	deleterious	0.05	0.35	0.22	neutral	0.63	disease	0.66	disease	0.67	disease	3	1	deleterious	0.3	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.28	medium_impact	2.34	high_impact	0.30	0.8	73.95	11.56	0.5	N	0.66	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9397	9397	A	G	MI.7037	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	191	64	E	G	gAa/gGa	9.15	1	0	probably_damaging	1	neutral	0.32	neutral	1.44	deleterious	-4.75	deleterious	-6.54	high_impact	3.52	0.52	damaging	0.06	damaging	3.97	23.60	deleterious	0.05	0.35	0.33	neutral	0.59	disease	0.69	disease	0.68	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	0.01	medium_impact	1.97	medium_impact	0.26	0.8	73.95	11.56	0.51	N	0.62	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9397	9397	A	T	MI.7038	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	191	64	E	V	gAa/gTa	9.15	1	0	probably_damaging	1	neutral	0.53	neutral	1.43	deleterious	-5.36	deleterious	-6.54	high_impact	4.07	0.5	damaging	0.04	damaging	3.91	23.50	deleterious	0.03	0.35	0.42	neutral	0.75	disease	0.7	disease	0.7	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	0.22	medium_impact	2.47	high_impact	0.26	0.8	73.95	11.56	0.51	N	0.83	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9398	9398	A	C	MI.7039	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	192	64	E	D	gaA/gaC	8.69	1	0	probably_damaging	0.98	neutral	0.18	neutral	1.51	deleterious	-3.5	deleterious	-2.8	medium_impact	3.21	0.53	damaging	0.04	damaging	3.62	23.20	deleterious	0.23	0.45	0.29	neutral	0.55	disease	0.56	disease	0.62	disease	2	0.98	deleterious	0.1	neutral	1	deleterious	0.74	deleterious	-2.51	low_impact	-0.18	medium_impact	1.69	medium_impact	0.61	0.8	73.95	11.56	0.58	P	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8858	8858	G	C	MI.704	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	332	111	G	A	gGc/gCc	5.91	0.99	0	possibly_damaging	0.56	neutral	0.82	neutral	4.5	neutral	0.73	neutral	-0.81	neutral_impact	-0.24	0.82	neutral	0.74	neutral	-0.01	2.48	deleterious	0.44	0.65	0.37	neutral	0.17	neutral	0.28	neutral	0.24	neutral	5	0.47	neutral	0.63	deleterious	-3	neutral	0.50	deleterious	-0.86	medium_impact	0.66	medium_impact	-1.3	low_impact	0.68	0.9	14.6	14.23	0.45	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9398	9398	A	T	MI.7040	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	192	64	E	D	gaA/gaT	8.69	1	0	probably_damaging	0.98	neutral	0.18	neutral	1.51	deleterious	-3.5	deleterious	-2.8	medium_impact	3.21	0.53	damaging	0.04	damaging	3.74	23.30	deleterious	0.23	0.45	0.29	neutral	0.55	disease	0.56	disease	0.62	disease	2	0.98	deleterious	0.1	neutral	1	deleterious	0.74	deleterious	-2.51	low_impact	-0.18	medium_impact	1.69	medium_impact	0.61	0.8	73.95	11.56	0.59	P	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9399	9399	A	G	MI.7041	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	193	65	S	G	Agc/Ggc	0.59	0.93	0	benign	0	neutral	0.48	neutral	2.37	neutral	0.26	neutral	1.86	neutral_impact	0.34	0.72	neutral	0.96	neutral	-1.33	0.00	neutral	0.18	0.45	0.15	neutral	0.03	neutral	0.26	neutral	0.19	neutral	6	0.52	neutral	0.74	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.17	medium_impact	-0.88	medium_impact	0.50	0.8	16.09	23.32	0.4	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9399	9399	A	T	MI.7042	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	193	65	S	C	Agc/Tgc	0.59	0.93	0	possibly_damaging	0.88	neutral	0.18	neutral	2.07	deleterious	-3.8	deleterious	-2.68	medium_impact	3.46	0.56	damaging	0.31	neutral	3.14	22.60	deleterious	0.07	0.35	0.6	disease	0.5	disease	0.66	disease	0.69	disease	4	0.93	neutral	0.15	neutral	0	NA	0.69	deleterious	-1.71	low_impact	-0.18	medium_impact	1.92	medium_impact	0.31	0.8	16.09	23.32	0.42	N	0.72	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9399	9399	A	C	MI.7043	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	193	65	S	R	Agc/Cgc	0.59	0.93	0	possibly_damaging	0.79	neutral	0.46	neutral	2.09	neutral	-2.86	neutral	-2.46	medium_impact	3.46	0.53	damaging	0.32	neutral	3.59	23.20	deleterious	0.07	0.35	0.27	neutral	0.5	disease	0.77	disease	0.73	disease	5	0.78	neutral	0.34	neutral	0	NA	0.66	deleterious	-1.43	low_impact	0.15	medium_impact	1.92	medium_impact	0.27	0.8	16.09	23.32	0.51	P	0.60	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9400	9400	G	T	MI.7044	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	194	65	S	I	aGc/aTc	0.13	0.92	0	possibly_damaging	0.86	neutral	0.44	neutral	2.08	deleterious	-3.25	deleterious	-3.62	high_impact	3.81	0.65	neutral	0.49	neutral	4.04	23.70	deleterious	0.07	0.35	0.29	neutral	0.53	disease	0.66	disease	0.7	disease	4	0.85	neutral	0.29	neutral	1	deleterious	0.65	deleterious	-1.64	low_impact	0.13	medium_impact	2.23	high_impact	0.32	0.8	16.09	23.32	0.45	N	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9400	9400	G	C	MI.7045	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	194	65	S	T	aGc/aCc	0.13	0.92	0	benign	0.11	neutral	0.53	neutral	2.15	neutral	-1.6	neutral	-1.81	medium_impact	2.84	0.6	damaging	0.46	neutral	2.94	22.00	deleterious	0.24	0.45	0.24	neutral	0.3	neutral	0.64	disease	0.48	neutral	0	0.38	neutral	0.71	deleterious	-3	neutral	0.18	neutral	0.01	medium_impact	0.22	medium_impact	1.36	medium_impact	0.46	0.8	16.09	23.32	0.42	N	0.30	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9400	9400	G	A	MI.7046	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	194	65	S	N	aGc/aAc	0.13	0.92	0	benign	0.13	neutral	0.39	neutral	2.1	neutral	-2.47	neutral	-1.37	medium_impact	2.52	0.6	neutral	0.37	neutral	1.99	16.13	deleterious	0.44	0.55	0.28	neutral	0.43	neutral	0.68	disease	0.51	disease	0	0.54	neutral	0.63	deleterious	-3	neutral	0.23	neutral	-0.07	medium_impact	0.08	medium_impact	1.08	medium_impact	0.34	0.8	16.09	23.32	0.42	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	COSM1138429	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9402	9402	A	C	MI.7047	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	196	66	T	P	Aca/Cca	-9.13	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.94	deleterious	-3.8	deleterious	-5.45	high_impact	3.71	0.65	neutral	0.05	damaging	3.49	23.10	deleterious	0.04	0.35	0.28	neutral	0.55	disease	0.74	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.74	deleterious	-2.81	low_impact	-0.15	medium_impact	2.14	high_impact	0.17	0.8	73.95	11.61	0.29	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9402	9402	A	G	MI.7048	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	196	66	T	A	Aca/Gca	-9.13	0	0	probably_damaging	0.96	neutral	0.5	neutral	2.05	neutral	-1.7	deleterious	-4.45	medium_impact	3.12	0.61	neutral	0.09	damaging	3.42	23.00	deleterious	0.35	0.5	0.19	neutral	0.38	neutral	0.61	disease	0.41	neutral	2	0.95	neutral	0.27	neutral	1	deleterious	0.66	deleterious	-2.21	low_impact	0.19	medium_impact	1.61	medium_impact	0.30	0.8	73.95	11.61	0.29	N	0.44	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9402	9402	A	T	MI.7049	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	196	66	T	S	Aca/Tca	-9.13	0	0	probably_damaging	0.96	neutral	0.41	neutral	2.05	neutral	-1.66	deleterious	-3.46	medium_impact	2.02	0.48	damaging	0.11	damaging	3.24	22.80	deleterious	0.49	0.55	0.19	neutral	0.28	neutral	0.32	neutral	0.38	neutral	2	0.96	neutral	0.23	neutral	1	deleterious	0.67	deleterious	-2.21	low_impact	0.1	medium_impact	0.63	medium_impact	0.37	0.8	73.95	11.61	0.34	N	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8858	8858	G	T	MI.705	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	332	111	G	V	gGc/gTc	5.91	0.99	0	probably_damaging	0.92	neutral	0.09	neutral	4.28	neutral	-1.42	deleterious	-4.05	medium_impact	2.16	0.78	neutral	0.43	neutral	3.73	23.30	deleterious	0.25	0.65	0.67	disease	0.86	disease	0.53	disease	0.73	disease	5	0.97	neutral	0.09	neutral	1	deleterious	0.79	deleterious	-1.76	low_impact	-0.28	medium_impact	0.75	medium_impact	0.63	0.9	14.6	14.23	0.46	N	0.94	polymorphism	0.96	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9403	9403	C	A	MI.7050	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	197	66	T	K	aCa/aAa	8.69	1	0	probably_damaging	0.99	neutral	0.29	neutral	1.99	neutral	-2.53	deleterious	-5.4	medium_impact	3.02	0.69	neutral	0.02	damaging	4.44	24.20	deleterious	0.09	0.35	0.17	neutral	0.48	neutral	0.65	disease	0.48	neutral	0	0.99	deleterious	0.15	neutral	1	deleterious	0.70	deleterious	-2.81	low_impact	-0.03	medium_impact	1.52	medium_impact	0.21	0.8	73.95	11.61	0.52	P	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9403	9403	C	T	MI.7051	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	197	66	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	neutral	0.22	neutral	1.93	deleterious	-4.28	deleterious	-5.43	medium_impact	2.92	0.64	neutral	0.01	damaging	3.99	23.60	deleterious	0.15	0.4	0.45	neutral	0.4	neutral	0.64	disease	0.44	neutral	1	1	deleterious	0.11	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	-0.12	medium_impact	1.43	medium_impact	0.40	0.8	73.95	11.61	0.5	P	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9405	9405	T	C	MI.7052	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	199	67	Y	H	Tac/Cac	-13.06	0	0	probably_damaging	1	neutral	0.55	neutral	2.22	neutral	-2.19	deleterious	-3.5	medium_impact	2.27	0.64	neutral	0.32	neutral	3.50	23.10	deleterious	0.26	0.45	0.4	neutral	0.3	neutral	0.58	disease	0.49	neutral	0	1	deleterious	0.28	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	0.24	medium_impact	0.85	medium_impact	0.12	0.8	20.31	40.32	0.29	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9405	9405	T	A	MI.7053	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	199	67	Y	N	Tac/Aac	-13.06	0	0	probably_damaging	1	neutral	0.31	neutral	2.22	neutral	-1.86	deleterious	-5.54	medium_impact	2.68	0.62	neutral	0.22	damaging	3.99	23.60	deleterious	0.15	0.45	0.33	neutral	0.53	disease	0.66	disease	0.7	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.01	medium_impact	1.22	medium_impact	0.17	0.8	20.31	40.32	0.29	N	0.90	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9405	9405	T	G	MI.7054	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	199	67	Y	D	Tac/Gac	-13.06	0	0	probably_damaging	1	neutral	0.21	neutral	2.24	neutral	-1.44	deleterious	-6.14	medium_impact	3.37	0.54	damaging	0.15	damaging	3.95	23.60	deleterious	0.11	0.4	0.4	neutral	0.58	disease	0.71	disease	0.75	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	-0.14	medium_impact	1.84	medium_impact	0.19	0.8	20.31	40.32	0.31	N	0.97	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9406	9406	A	G	MI.7055	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	200	67	Y	C	tAc/tGc	5.68	0.99	0	probably_damaging	1	neutral	0.18	neutral	2.2	neutral	-2.82	deleterious	-5	medium_impact	2.82	0.55	damaging	0.13	damaging	3.35	22.90	deleterious	0.1	0.4	0.41	neutral	0.59	disease	0.61	disease	0.69	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	-0.18	medium_impact	1.35	medium_impact	0.01	0.8	20.31	40.32	0.46	N	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9406	9406	A	C	MI.7056	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	200	67	Y	S	tAc/tCc	5.68	0.99	0	probably_damaging	0.99	neutral	0.41	neutral	2.25	neutral	-1.01	deleterious	-5.12	medium_impact	2.82	0.59	damaging	0.22	damaging	3.54	23.10	deleterious	0.11	0.4	0.14	neutral	0.46	neutral	0.66	disease	0.52	disease	0	0.99	deleterious	0.21	neutral	1	deleterious	0.70	deleterious	-2.81	low_impact	0.1	medium_impact	1.35	medium_impact	0.12	0.8	20.31	40.32	0.48	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9406	9406	A	T	MI.7057	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	200	67	Y	F	tAc/tTc	5.68	0.99	0	probably_damaging	0.98	neutral	0.75	neutral	2.4	neutral	0.71	neutral	0.21	neutral_impact	-0.5	0.76	neutral	0.98	neutral	0.52	7.62	deleterious	0.28	0.45	0.15	neutral	0.03	neutral	0.24	neutral	0.2	neutral	6	0.98	neutral	0.39	neutral	-2	neutral	0.65	deleterious	-2.51	low_impact	0.46	medium_impact	-1.63	low_impact	0.17	0.8	20.31	40.32	0.57	P	0.14	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9408	9408	C	A	MI.7058	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	202	68	Q	K	Caa/Aaa	-1.26	0.01	0	probably_damaging	0.98	neutral	0.3	neutral	2.29	neutral	0.36	deleterious	-3.49	medium_impact	2.44	0.69	neutral	0.03	damaging	3.95	23.60	deleterious	0.48	0.55	0.15	neutral	0.57	disease	0.6	disease	0.56	disease	1	0.98	deleterious	0.16	neutral	1	deleterious	0.71	deleterious	-2.51	low_impact	-0.02	medium_impact	1	medium_impact	0.24	0.8	73.56	11.66	0.28	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9408	9408	C	G	MI.7059	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	202	68	Q	E	Caa/Gaa	-1.26	0.01	0	probably_damaging	0.95	neutral	0.28	neutral	2.31	neutral	0.58	deleterious	-2.67	low_impact	1.8	0.62	neutral	0.04	damaging	2.99	22.20	deleterious	0.48	0.55	0.12	neutral	0.34	neutral	0.35	neutral	0.4	neutral	2	0.96	neutral	0.17	neutral	-2	neutral	0.69	deleterious	-2.11	low_impact	-0.04	medium_impact	0.43	medium_impact	0.15	0.8	73.56	11.66	0.3	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8858	8858	G	A	MI.706	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	332	111	G	D	gGc/gAc	5.91	0.99	0	possibly_damaging	0.78	deleterious	0.03	neutral	4.23	deleterious	-3.17	deleterious	-4.04	medium_impact	3.36	0.76	neutral	0.36	neutral	3.61	23.20	deleterious	0.13	0.65	0.82	disease	0.9	disease	0.68	disease	0.79	disease	6	0.98	neutral	0.13	neutral	4	deleterious	0.82	deleterious	-1.28	low_impact	-0.56	medium_impact	1.78	medium_impact	0.48	0.9	14.6	14.23	0.55	P	0.73	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9409	9409	A	G	MI.7060	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	203	68	Q	R	cAa/cGa	5.45	1	0	probably_damaging	0.99	neutral	0.35	neutral	2.24	neutral	-0.24	deleterious	-3.51	medium_impact	2.75	0.72	neutral	0.02	damaging	3.42	23.00	deleterious	0.53	0.6	0.18	neutral	0.56	disease	0.64	disease	0.64	disease	3	0.99	deleterious	0.18	neutral	1	deleterious	0.73	deleterious	-2.81	low_impact	0.04	medium_impact	1.28	medium_impact	0.10	0.8	73.56	11.66	0.46	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9409	9409	A	T	MI.7061	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	203	68	Q	L	cAa/cTa	5.45	1	0	probably_damaging	0.98	neutral	0.65	neutral	2.28	neutral	-0.9	deleterious	-5.93	low_impact	1.4	0.59	damaging	0.18	damaging	3.69	23.30	deleterious	0.14	0.4	0.23	neutral	0.41	neutral	0.35	neutral	0.4	neutral	2	0.98	neutral	0.34	neutral	-2	neutral	0.72	deleterious	-2.51	low_impact	0.35	medium_impact	0.07	medium_impact	0.21	0.8	73.56	11.66	0.39	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9409	9409	A	C	MI.7062	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	203	68	Q	P	cAa/cCa	5.45	1	0	probably_damaging	0.99	neutral	0.2	neutral	2.19	neutral	-1.62	deleterious	-5.32	medium_impact	3.06	0.67	neutral	0.02	damaging	3.31	22.90	deleterious	0.07	0.35	0.39	neutral	0.73	disease	0.61	disease	0.65	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.80	deleterious	-2.81	low_impact	-0.15	medium_impact	1.56	medium_impact	0.22	0.8	73.56	11.66	0.39	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9410	9410	A	T	MI.7063	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	204	68	Q	H	caA/caT	5.45	1	0.01	probably_damaging	1	neutral	0.54	neutral	2.21	neutral	-1.32	deleterious	-4.45	medium_impact	2.99	0.61	neutral	0.02	damaging	3.48	23.10	deleterious	0.33	0.5	0.21	neutral	0.52	disease	0.53	disease	0.51	disease	0	1	deleterious	0.27	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	0.23	medium_impact	1.5	medium_impact	0.26	0.8	73.56	11.66	0.4	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9410	9410	A	C	MI.7064	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	204	68	Q	H	caA/caC	5.45	1	0.01	probably_damaging	1	neutral	0.54	neutral	2.21	neutral	-1.32	deleterious	-4.45	medium_impact	2.99	0.61	neutral	0.02	damaging	3.36	22.90	deleterious	0.33	0.5	0.21	neutral	0.52	disease	0.53	disease	0.51	disease	0	1	deleterious	0.27	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	0.23	medium_impact	1.5	medium_impact	0.26	0.8	73.56	11.66	0.39	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9411	9411	G	A	MI.7065	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	205	69	G	S	Ggc/Agc	1.29	1	0	probably_damaging	1	neutral	0.4	neutral	0.94	deleterious	-5.26	deleterious	-5.62	high_impact	4.27	0.57	damaging	0.02	damaging	4.16	23.80	deleterious	0.17	0.45	0.18	neutral	0.76	disease	0.65	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	0.09	medium_impact	2.64	high_impact	0.50	0.8	74.33	11.61	0.41	N	0.85	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9411	9411	G	C	MI.7066	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	205	69	G	R	Ggc/Cgc	1.29	1	0	probably_damaging	1	neutral	0.33	neutral	0.9	deleterious	-6.58	deleterious	-7.51	medium_impact	3.46	0.63	neutral	0.02	damaging	3.90	23.50	deleterious	0.09	0.35	0.25	neutral	0.77	disease	0.75	disease	0.74	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	0.02	medium_impact	1.92	medium_impact	0.55	0.8	74.33	11.61	0.34	N	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9411	9411	G	T	MI.7067	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	205	69	G	C	Ggc/Tgc	1.29	1	0	probably_damaging	1	neutral	0.18	neutral	0.89	deleterious	-7.58	deleterious	-8.45	high_impact	4.62	0.56	damaging	0.02	damaging	4.06	23.70	deleterious	0.07	0.35	0.7	disease	0.82	disease	0.74	disease	0.76	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.18	medium_impact	2.96	high_impact	0.08	0.8	74.33	11.61	0.47	N	0.98	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9412	9412	G	C	MI.7068	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	206	69	G	A	gGc/gCc	6.14	1	0	probably_damaging	1	neutral	0.5	neutral	0.95	deleterious	-4.99	deleterious	-5.63	high_impact	4.07	0.57	damaging	0.01	damaging	3.03	22.30	deleterious	0.23	0.45	0.19	neutral	0.62	disease	0.71	disease	0.7	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	0.19	medium_impact	2.47	high_impact	0.21	0.8	74.33	11.61	0.46	N	0.30	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9412	9412	G	A	MI.7069	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	206	69	G	D	gGc/gAc	6.14	1	0	probably_damaging	1	neutral	0.2	neutral	0.91	deleterious	-6.07	deleterious	-6.57	medium_impact	3.15	0.49	damaging	0.02	damaging	3.83	23.40	deleterious	0.08	0.35	0.25	neutral	0.81	disease	0.74	disease	0.73	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	-0.15	medium_impact	1.64	medium_impact	0.07	0.8	74.33	11.61	0.44	N	0.98	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8860	8860	A	T	MI.707	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	334	112	T	S	Aca/Tca	-9.59	0	0.24	benign	0.07	neutral	0.4	neutral	4.21	neutral	-1.87	deleterious	-3.36	medium_impact	2.32	0.64	neutral	0.61	neutral	1.39	12.76	neutral	0.39	0.65	0.34	neutral	0.78	disease	0.63	disease	0.61	disease	2	0.55	neutral	0.67	deleterious	-3	neutral	0.22	neutral	0.31	medium_impact	0.19	medium_impact	0.89	medium_impact	0.72	0.9	5.75	12.69	0.34	N	0.38	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9412	9412	G	T	MI.7070	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	206	69	G	V	gGc/gTc	6.14	1	0	probably_damaging	1	neutral	0.48	neutral	0.9	deleterious	-6.37	deleterious	-8.45	high_impact	4.27	0.52	damaging	0.01	damaging	3.70	23.30	deleterious	0.06	0.35	0.36	neutral	0.82	disease	0.75	disease	0.75	disease	5	1	deleterious	0.24	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	0.17	medium_impact	2.64	high_impact	0.03	0.8	74.33	11.61	0.46	N	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9414	9414	C	G	MI.7071	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	208	70	H	D	Cac/Gac	-12.6	0	0	probably_damaging	0.98	neutral	0.2	neutral	2.55	neutral	-0.15	deleterious	-4.99	low_impact	1.53	0.49	damaging	0.05	damaging	3.77	23.40	deleterious	0.2	0.45	0.21	neutral	0.37	neutral	0.59	disease	0.46	neutral	1	0.99	deleterious	0.11	neutral	-2	neutral	0.69	deleterious	-2.51	low_impact	-0.15	medium_impact	0.19	medium_impact	0.33	0.8	73.95	11.47	0.3	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9414	9414	C	A	MI.7072	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	208	70	H	N	Cac/Aac	-12.6	0	0	probably_damaging	0.98	neutral	0.31	neutral	2.51	neutral	-0.81	deleterious	-3.45	medium_impact	1.98	0.54	damaging	0.09	damaging	3.79	23.40	deleterious	0.5	0.6	0.26	neutral	0.38	neutral	0.43	neutral	0.44	neutral	1	0.98	neutral	0.17	neutral	1	deleterious	0.68	deleterious	-2.51	low_impact	-0.01	medium_impact	0.59	medium_impact	0.20	0.8	73.95	11.47	0.28	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9414	9414	C	T	MI.7073	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	208	70	H	Y	Cac/Tac	-12.6	0	0	probably_damaging	0.96	neutral	1	neutral	2.53	neutral	-1.88	deleterious	-2.81	low_impact	1.25	0.5	damaging	0.06	damaging	2.64	20.50	deleterious	0.28	0.45	0.36	neutral	0.42	neutral	0.32	neutral	0.47	neutral	1	0.96	neutral	0.52	deleterious	-2	neutral	0.72	deleterious	-2.21	low_impact	1.9	high_impact	-0.06	medium_impact	0.13	0.8	73.95	11.47	0.2	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9415	9415	A	C	MI.7074	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	209	70	H	P	cAc/cCc	5.45	1	0	probably_damaging	0.99	neutral	0.2	neutral	2.53	neutral	-2.13	deleterious	-5.53	medium_impact	3.2	0.45	damaging	0.03	damaging	3.63	23.20	deleterious	0.09	0.35	0.43	neutral	0.72	disease	0.54	disease	0.68	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.81	deleterious	-2.81	low_impact	-0.15	medium_impact	1.69	medium_impact	0.13	0.8	73.95	11.47	0.46	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9415	9415	A	T	MI.7075	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	209	70	H	L	cAc/cTc	5.45	1	0	probably_damaging	0.97	neutral	0.68	neutral	2.63	neutral	-0.34	deleterious	-4.77	low_impact	1.32	0.55	damaging	0.08	damaging	2.90	21.90	deleterious	0.18	0.45	0.25	neutral	0.27	neutral	0.37	neutral	0.43	neutral	2	0.96	neutral	0.36	neutral	-2	neutral	0.68	deleterious	-2.34	low_impact	0.38	medium_impact	0	medium_impact	0.10	0.8	73.95	11.47	0.39	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9415	9415	A	G	MI.7076	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	209	70	H	R	cAc/cGc	5.45	1	0	probably_damaging	0.97	neutral	0.35	neutral	2.53	neutral	-0.59	deleterious	-3.98	medium_impact	2.58	0.48	damaging	0.05	damaging	3.40	23.00	deleterious	0.22	0.45	0.25	neutral	0.41	neutral	0.49	neutral	0.45	neutral	1	0.97	neutral	0.19	neutral	1	deleterious	0.70	deleterious	-2.34	low_impact	0.04	medium_impact	1.13	medium_impact	0.11	0.8	73.95	11.47	0.48	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9416	9416	C	A	MI.7077	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	210	70	H	Q	caC/caA	8.69	1	0	probably_damaging	0.98	neutral	0.34	neutral	2.53	neutral	-0.49	deleterious	-3.93	low_impact	1.37	0.54	damaging	0.05	damaging	3.82	23.40	deleterious	0.35	0.5	0.23	neutral	0.34	neutral	0.4	neutral	0.44	neutral	1	0.98	deleterious	0.18	neutral	-2	neutral	0.69	deleterious	-2.51	low_impact	0.03	medium_impact	0.05	medium_impact	0.25	0.8	73.95	11.47	0.5	P	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9416	9416	C	G	MI.7078	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	210	70	H	Q	caC/caG	8.69	1	0	probably_damaging	0.98	neutral	0.34	neutral	2.53	neutral	-0.49	deleterious	-3.93	low_impact	1.37	0.54	damaging	0.05	damaging	3.48	23.10	deleterious	0.35	0.5	0.23	neutral	0.34	neutral	0.4	neutral	0.44	neutral	1	0.98	deleterious	0.18	neutral	-2	neutral	0.69	deleterious	-2.51	low_impact	0.03	medium_impact	0.05	medium_impact	0.25	0.8	73.95	11.47	0.5	P	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9417	9417	C	T	MI.7079	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	211	71	H	Y	Cac/Tac	-1.03	0.01	0	probably_damaging	0.99	neutral	1	neutral	1.45	deleterious	-4.71	deleterious	-5.64	medium_impact	2.6	0.59	damaging	0.02	damaging	3.62	23.20	deleterious	0.38	0.5	0.46	neutral	0.75	disease	0.74	disease	0.72	disease	4	0.99	deleterious	0.51	deleterious	1	deleterious	0.80	deleterious	-2.81	low_impact	1.9	high_impact	1.15	medium_impact	0.13	0.8	74.71	11.46	0.21	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8860	8860	A	G	MI.708	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	334	112	T	A	Aca/Gca	-9.59	0	0.24	benign	0	neutral	0.61	neutral	4.23	neutral	-0.73	deleterious	-3.97	medium_impact	2.15	0.96	neutral	0.91	neutral	0.35	6.13	deleterious	0.47	0.65	0.33	neutral	0.7	disease	0.61	disease	0.52	disease	0	0.38	neutral	0.81	deleterious	-3	neutral	0.14	neutral	2.09	high_impact	0.4	medium_impact	0.75	medium_impact	0.43	0.9	5.75	12.69	0.27	N	0.00	polymorphism	1	0.07	rs2001031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9417	9417	C	G	MI.7080	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	211	71	H	D	Cac/Gac	-1.03	0.01	0	probably_damaging	1	neutral	0.21	neutral	1.45	deleterious	-4.66	deleterious	-8.47	high_impact	4.22	0.58	damaging	0.02	damaging	3.77	23.40	deleterious	0.13	0.4	0.2	neutral	0.74	disease	0.81	disease	0.75	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	-0.14	medium_impact	2.6	high_impact	0.24	0.8	74.71	11.46	0.39	N	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9417	9417	C	A	MI.7081	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	211	71	H	N	Cac/Aac	-1.03	0.01	0	probably_damaging	0.99	neutral	0.31	neutral	1.44	deleterious	-4.93	deleterious	-6.58	medium_impact	3.25	0.58	damaging	0.02	damaging	3.94	23.50	deleterious	0.43	0.55	0.23	neutral	0.73	disease	0.78	disease	0.73	disease	5	0.99	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	-0.01	medium_impact	1.73	medium_impact	0.14	0.8	74.71	11.46	0.32	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9418	9418	A	T	MI.7082	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	212	71	H	L	cAc/cTc	7.3	1	0	probably_damaging	0.99	neutral	0.67	neutral	1.44	deleterious	-4.8	deleterious	-10.35	high_impact	3.76	0.56	damaging	0.02	damaging	3.84	23.40	deleterious	0.12	0.4	0.3	neutral	0.76	disease	0.78	disease	0.74	disease	5	0.99	deleterious	0.34	neutral	2	deleterious	0.77	deleterious	-2.81	low_impact	0.37	medium_impact	2.19	high_impact	0.09	0.8	74.71	11.46	0.48	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9418	9418	A	C	MI.7083	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	212	71	H	P	cAc/cCc	7.3	1	0	probably_damaging	1	neutral	0.21	neutral	1.42	deleterious	-5.91	deleterious	-9.41	high_impact	3.52	0.58	damaging	0.03	damaging	3.15	22.60	deleterious	0.06	0.35	0.32	neutral	0.78	disease	0.78	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.14	medium_impact	1.97	medium_impact	0.09	0.8	74.71	11.46	0.44	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9418	9418	A	G	MI.7084	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	212	71	H	R	cAc/cGc	7.3	1	0	probably_damaging	0.99	neutral	0.35	neutral	1.46	deleterious	-4.47	deleterious	-7.53	high_impact	3.6	0.66	neutral	0.02	damaging	2.95	22.10	deleterious	0.23	0.45	0.23	neutral	0.7	disease	0.77	disease	0.73	disease	5	0.99	deleterious	0.18	neutral	2	deleterious	0.77	deleterious	-2.81	low_impact	0.04	medium_impact	2.04	high_impact	0.12	0.8	74.71	11.46	0.49	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9419	9419	C	G	MI.7085	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	213	71	H	Q	caC/caG	7.07	1	0	probably_damaging	1	neutral	0.3	neutral	1.44	deleterious	-4.89	deleterious	-7.53	medium_impact	3.37	0.62	neutral	0.02	damaging	3.48	23.10	deleterious	0.3	0.45	0.16	neutral	0.73	disease	0.78	disease	0.73	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.02	medium_impact	1.84	medium_impact	0.19	0.8	74.71	11.46	0.45	N	0.94	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9419	9419	C	A	MI.7086	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	213	71	H	Q	caC/caA	7.07	1	0	probably_damaging	1	neutral	0.3	neutral	1.44	deleterious	-4.89	deleterious	-7.53	medium_impact	3.37	0.62	neutral	0.02	damaging	3.81	23.40	deleterious	0.3	0.45	0.16	neutral	0.73	disease	0.78	disease	0.73	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.02	medium_impact	1.84	medium_impact	0.19	0.8	74.71	11.46	0.46	N	0.94	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9420	9420	A	G	MI.7087	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	214	72	T	A	Aca/Gca	-2.42	0	0	probably_damaging	0.95	neutral	0.52	neutral	2	neutral	-1.94	deleterious	-4.7	medium_impact	3.12	0.65	neutral	0.05	damaging	1.56	13.63	neutral	0.36	0.5	0.19	neutral	0.47	neutral	0.65	disease	0.48	neutral	0	0.95	neutral	0.29	neutral	1	deleterious	0.68	deleterious	-2.11	low_impact	0.21	medium_impact	1.61	medium_impact	0.19	0.8	74.33	11.62	0.27	N	0.44	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9420	9420	A	C	MI.7088	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	214	72	T	P	Aca/Cca	-2.42	0	0	probably_damaging	0.99	neutral	0.21	neutral	1.9	deleterious	-4.02	deleterious	-5.64	high_impact	3.9	0.63	neutral	0.05	damaging	3.35	22.90	deleterious	0.08	0.35	0.44	neutral	0.65	disease	0.62	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.78	deleterious	-2.81	low_impact	-0.14	medium_impact	2.31	high_impact	0.15	0.8	74.33	11.62	0.3	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9420	9420	A	T	MI.7089	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	214	72	T	S	Aca/Tca	-2.42	0	0	probably_damaging	0.95	neutral	0.42	neutral	2.01	neutral	-1.84	deleterious	-3.75	low_impact	1.58	0.48	damaging	0.11	damaging	1.21	11.78	neutral	0.47	0.55	0.16	neutral	0.36	neutral	0.31	neutral	0.39	neutral	2	0.95	neutral	0.24	neutral	-2	neutral	0.69	deleterious	-2.11	low_impact	0.11	medium_impact	0.23	medium_impact	0.27	0.8	74.33	11.62	0.31	N	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8860	8860	A	C	MI.709	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	334	112	T	P	Aca/Cca	-9.59	0	0.24	benign	0.28	neutral	0.22	neutral	4.17	deleterious	-3.73	deleterious	-5.25	medium_impact	3.08	0.52	damaging	0.44	neutral	1.81	15.05	deleterious	0.11	0.65	0.8	disease	0.92	disease	0.76	disease	0.78	disease	6	0.74	neutral	0.47	deleterious	-3	neutral	0.54	deleterious	-0.37	medium_impact	-0.02	medium_impact	1.54	medium_impact	0.60	0.9	5.75	12.69	0.35	N	0.79	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9421	9421	C	T	MI.7090	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	215	72	T	M	aCa/aTa	6.84	1	0	probably_damaging	1	neutral	0.23	neutral	1.89	deleterious	-4.51	deleterious	-5.64	high_impact	4.45	0.68	neutral	0.01	damaging	3.98	23.60	deleterious	0.18	0.45	0.48	neutral	0.6	disease	0.65	disease	0.65	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.74	deleterious	-3.78	low_impact	-0.11	medium_impact	2.81	high_impact	0.26	0.8	74.33	11.62	0.54	P	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9421	9421	C	A	MI.7091	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	215	72	T	K	aCa/aAa	6.84	1	0	probably_damaging	0.99	neutral	0.32	neutral	1.95	neutral	-2.7	deleterious	-5.63	high_impact	3.75	0.69	neutral	0.02	damaging	4.09	23.70	deleterious	0.11	0.4	0.16	neutral	0.66	disease	0.7	disease	0.69	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.73	deleterious	-2.81	low_impact	0.01	medium_impact	2.18	high_impact	0.10	0.8	74.33	11.62	0.5	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9423	9423	C	G	MI.7092	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	217	73	P	A	Cca/Gca	-12.6	0	0	benign	0	neutral	0.72	neutral	2.62	neutral	0.49	neutral	-0.18	neutral_impact	0.76	0.69	neutral	0.6	neutral	-0.30	0.66	neutral	0.31	0.5	0.1	neutral	0.13	neutral	0.25	neutral	0.27	neutral	5	0.28	neutral	0.86	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.43	medium_impact	-0.5	medium_impact	0.38	0.8	19.54	40.68	0.38	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9423	9423	C	T	MI.7093	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	217	73	P	S	Cca/Tca	-12.6	0	0	benign	0.01	neutral	0.67	neutral	2.62	neutral	0.1	neutral	0.41	neutral_impact	-0.18	0.77	neutral	0.84	neutral	0.26	5.29	deleterious	0.35	0.5	0.09	neutral	0.12	neutral	0.12	neutral	0.29	neutral	4	0.32	neutral	0.83	deleterious	-6	neutral	0.09	neutral	1.07	medium_impact	0.37	medium_impact	-1.34	low_impact	0.28	0.8	19.54	40.68	0.43	N	0.51	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9423	9423	C	A	MI.7094	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	217	73	P	T	Cca/Aca	-12.6	0	0	benign	0	neutral	0.76	neutral	2.62	neutral	-0.04	neutral	-0.07	neutral_impact	0.68	0.7	neutral	0.78	neutral	0.14	4.07	deleterious	0.27	0.45	0.09	neutral	0.17	neutral	0.13	neutral	0.3	neutral	4	0.24	neutral	0.88	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	0.48	medium_impact	-0.57	medium_impact	0.27	0.8	19.54	40.68	0.47	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9424	9424	C	T	MI.7095	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	218	73	P	L	cCa/cTa	-0.1	0	0	benign	0	neutral	0.74	neutral	2.67	neutral	-0.68	neutral	-0.95	neutral_impact	0.27	0.75	neutral	0.89	neutral	0.53	7.64	deleterious	0.19	0.45	0.11	neutral	0.16	neutral	0.15	neutral	0.27	neutral	5	0.26	neutral	0.87	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.45	medium_impact	-0.94	medium_impact	0.64	0.8	19.54	40.68	0.44	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9424	9424	C	A	MI.7096	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	218	73	P	Q	cCa/cAa	-0.1	0	0	benign	0.04	neutral	0.44	neutral	2.56	neutral	-0.1	neutral	-0.49	low_impact	1.6	0.7	neutral	0.54	neutral	0.90	10.07	neutral	0.24	0.45	0.12	neutral	0.22	neutral	0.32	neutral	0.4	neutral	2	0.52	neutral	0.7	deleterious	-6	neutral	0.12	neutral	0.47	medium_impact	0.13	medium_impact	0.25	medium_impact	0.18	0.8	19.54	40.68	0.41	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9424	9424	C	G	MI.7097	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	218	73	P	R	cCa/cGa	-0.1	0	0	benign	0.03	neutral	0.47	neutral	2.58	neutral	0.39	neutral	-0.89	low_impact	1.14	0.62	neutral	0.4	neutral	0.38	6.46	deleterious	0.16	0.45	0.13	neutral	0.27	neutral	0.41	neutral	0.42	neutral	2	0.5	neutral	0.72	deleterious	-6	neutral	0.13	neutral	0.6	medium_impact	0.16	medium_impact	-0.16	medium_impact	0.25	0.8	19.54	40.68	0.38	N	0.80	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9426	9426	C	G	MI.7098	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	220	74	P	A	Cct/Gct	-12.83	0	0	benign	0.13	neutral	0.58	neutral	2.46	neutral	1.27	neutral	-0.7	neutral_impact	-0.18	0.69	neutral	0.91	neutral	0.09	3.53	deleterious	0.35	0.5	0.11	neutral	0.14	neutral	0.32	neutral	0.26	neutral	5	0.32	neutral	0.73	deleterious	-6	neutral	0.14	neutral	-0.07	medium_impact	0.27	medium_impact	-1.34	low_impact	0.53	0.8	16.86	35.62	0.43	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9426	9426	C	T	MI.7099	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	220	74	P	S	Cct/Tct	-12.83	0	0	benign	0.02	neutral	0.5	neutral	2.37	neutral	1.02	neutral	-0.96	neutral_impact	0.7	0.74	neutral	0.53	neutral	0.63	8.37	deleterious	0.37	0.5	0.11	neutral	0.21	neutral	0.3	neutral	0.35	neutral	3	0.47	neutral	0.74	deleterious	-6	neutral	0.10	neutral	0.77	medium_impact	0.19	medium_impact	-0.56	medium_impact	0.24	0.8	16.86	35.62	0.39	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	COSM6716210	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8557	8557	G	C	MI.71	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	31	11	A	P	Gcc/Ccc	-0.8	0	0.02	possibly_damaging	0.56	neutral	1	neutral	4.71	neutral	-1.53	neutral	-1.8	neutral_impact	-0.55	0.81	neutral	0.57	neutral	3.20	22.70	deleterious	0.27	0.65	0.46	neutral	0.73	disease	0.22	neutral	0.48	neutral	0	0.56	neutral	0.72	deleterious	-3	neutral	0.64	deleterious	-0.86	medium_impact	1.98	high_impact	-1.57	low_impact	0.62	0.9	23.45	19.76	0.19	N	0.75	polymorphism	1	0.03	rs386829040	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8861	8861	C	T	MI.710	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	335	112	T	M	aCa/aTa	0.59	0.04	0	possibly_damaging	0.64	neutral	0.25	neutral	4.22	neutral	-1.94	deleterious	-5.24	medium_impact	2.5	0.69	neutral	0.56	neutral	3.65	23.20	deleterious	0.29	0.65	0.61	disease	0.83	disease	0.59	disease	0.61	disease	2	0.78	neutral	0.31	neutral	0	NA	0.55	deleterious	-0.99	medium_impact	0.02	medium_impact	1.05	medium_impact	0.77	0.9	5.75	12.69	0.34	N	0.82	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9426	9426	C	A	MI.7100	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	220	74	P	T	Cct/Act	-12.83	0	0	benign	0.3	neutral	0.5	neutral	2.4	neutral	0.85	neutral	-0.79	neutral_impact	0.14	0.75	neutral	0.96	neutral	1.94	15.81	deleterious	0.26	0.45	0.12	neutral	0.22	neutral	0.31	neutral	0.38	neutral	2	0.4	neutral	0.6	deleterious	-6	neutral	0.19	neutral	-0.51	medium_impact	0.19	medium_impact	-1.06	low_impact	0.36	0.8	16.86	35.62	0.4	N	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9427	9427	C	G	MI.7101	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	221	74	P	R	cCt/cGt	-0.33	0	0	possibly_damaging	0.69	neutral	0.4	neutral	2.34	neutral	1.2	neutral	-1.5	neutral_impact	0.12	0.63	neutral	0.22	damaging	2.26	17.88	deleterious	0.16	0.45	0.14	neutral	0.4	neutral	0.44	neutral	0.44	neutral	1	0.71	neutral	0.36	neutral	-3	neutral	0.42	neutral	-1.21	low_impact	0.09	medium_impact	-1.08	low_impact	0.36	0.8	16.86	35.62	0.28	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9427	9427	C	T	MI.7102	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	221	74	P	L	cCt/cTt	-0.33	0	0	benign	0.42	neutral	0.7	neutral	2.44	neutral	0.31	neutral	-0.72	neutral_impact	0.35	0.71	neutral	0.31	neutral	2.69	20.80	deleterious	0.2	0.45	0.09	neutral	0.27	neutral	0.32	neutral	0.41	neutral	2	0.32	neutral	0.64	deleterious	-6	neutral	0.26	neutral	-0.73	medium_impact	0.4	medium_impact	-0.87	medium_impact	0.54	0.8	16.86	35.62	0.26	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9427	9427	C	A	MI.7103	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	221	74	P	H	cCt/cAt	-0.33	0	0	possibly_damaging	0.86	neutral	0.56	neutral	2.32	neutral	-0.47	neutral	-1.93	low_impact	1.07	0.69	neutral	0.24	damaging	2.84	21.60	deleterious	0.23	0.45	0.24	neutral	0.31	neutral	0.26	neutral	0.45	neutral	1	0.84	neutral	0.35	neutral	-3	neutral	0.57	deleterious	-1.64	low_impact	0.25	medium_impact	-0.22	medium_impact	0.28	0.8	16.86	35.62	0.28	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9429	9429	G	A	MI.7104	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	223	75	V	I	Gtc/Atc	-9.13	0	0	probably_damaging	0.93	neutral	0.49	neutral	1.84	neutral	-1.68	neutral	-0.93	medium_impact	3	0.52	damaging	0.63	neutral	3.57	23.10	deleterious	0.43	0.55	0.3	neutral	0.5	neutral	0.59	disease	0.47	neutral	1	0.92	neutral	0.28	neutral	1	deleterious	0.69	deleterious	-1.96	low_impact	0.18	medium_impact	1.51	medium_impact	0.66	0.8	73.56	11.46	0.45	N	0.21	polymorphism	1	0.03	.	.	.	.	.	.	COSM6716213	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9429	9429	G	C	MI.7105	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	223	75	V	L	Gtc/Ctc	-9.13	0	0	probably_damaging	0.93	neutral	0.72	neutral	1.73	neutral	-2.44	deleterious	-2.77	medium_impact	2.88	0.55	damaging	0.55	neutral	3.57	23.10	deleterious	0.29	0.45	0.25	neutral	0.7	disease	0.56	disease	0.59	disease	2	0.92	neutral	0.4	neutral	1	deleterious	0.73	deleterious	-1.96	low_impact	0.43	medium_impact	1.4	medium_impact	0.43	0.8	73.56	11.46	0.3	N	0.68	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9429	9429	G	T	MI.7106	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	223	75	V	F	Gtc/Ttc	-9.13	0	0	probably_damaging	1	neutral	0.54	neutral	1.6	deleterious	-4.67	deleterious	-4.63	high_impact	4.53	0.52	damaging	0.5	neutral	3.83	23.40	deleterious	0.12	0.4	0.44	neutral	0.88	disease	0.72	disease	0.76	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.23	medium_impact	2.88	high_impact	0.14	0.8	73.56	11.46	0.5	N	0.94	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9430	9430	T	A	MI.7107	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	224	75	V	D	gTc/gAc	7.53	1	0	probably_damaging	1	neutral	0.62	neutral	1.57	deleterious	-6.24	deleterious	-6.42	high_impact	4.18	0.6	damaging	0.5	neutral	4.40	24.10	deleterious	0.04	0.35	0.29	neutral	0.88	disease	0.78	disease	0.76	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.31	medium_impact	2.56	high_impact	0.05	0.8	73.56	11.46	0.56	P	0.94	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9430	9430	T	C	MI.7108	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	224	75	V	A	gTc/gCc	7.53	1	0	probably_damaging	0.99	neutral	0.85	neutral	1.63	deleterious	-3.84	deleterious	-3.67	high_impact	3.63	0.58	damaging	0.65	neutral	3.49	23.10	deleterious	0.28	0.45	0.21	neutral	0.66	disease	0.66	disease	0.66	disease	3	0.99	deleterious	0.43	neutral	2	deleterious	0.75	deleterious	-2.81	low_impact	0.62	medium_impact	2.07	high_impact	0.20	0.8	73.56	11.46	0.53	N	0.39	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9430	9430	T	G	MI.7109	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	224	75	V	G	gTc/gGc	7.53	1	0	probably_damaging	1	neutral	0.58	neutral	1.58	deleterious	-5.67	deleterious	-6.44	high_impact	3.56	0.57	damaging	0.61	neutral	3.75	23.30	deleterious	0.06	0.35	0.36	neutral	0.76	disease	0.68	disease	0.68	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	0.27	medium_impact	2.01	high_impact	0.17	0.8	73.56	11.46	0.48	N	0.88	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8861	8861	C	A	MI.711	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	335	112	T	K	aCa/aAa	0.59	0.04	0	benign	0.11	neutral	0.29	neutral	4.18	deleterious	-3.05	deleterious	-5.24	high_impact	3.54	0.61	neutral	0.45	neutral	2.56	19.82	deleterious	0.13	0.65	0.73	disease	0.93	disease	0.75	disease	0.79	disease	6	0.67	neutral	0.59	deleterious	-2	neutral	0.40	neutral	0.11	medium_impact	0.07	medium_impact	1.94	medium_impact	0.75	0.9	5.75	12.69	0.4	N	0.78	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9432	9432	C	G	MI.7110	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	226	76	Q	E	Caa/Gaa	-13.75	0	0	probably_damaging	0.91	neutral	0.32	neutral	2.29	neutral	0.01	neutral	-1.12	low_impact	1.38	0.5	damaging	0.07	damaging	3.04	22.30	deleterious	0.42	0.55	0.13	neutral	0.69	disease	0.31	neutral	0.53	disease	1	0.92	neutral	0.21	neutral	-2	neutral	0.69	deleterious	-1.85	low_impact	0.01	medium_impact	0.05	medium_impact	0.34	0.8	73.95	11.67	0.27	N	0.95	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9432	9432	C	A	MI.7111	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	226	76	Q	K	Caa/Aaa	-13.75	0	0	probably_damaging	0.96	neutral	0.35	neutral	2.3	neutral	0	neutral	-1.65	low_impact	1.61	0.49	damaging	0.11	damaging	3.88	23.50	deleterious	0.39	0.5	0.15	neutral	0.69	disease	0.31	neutral	0.48	neutral	0	0.96	neutral	0.2	neutral	-2	neutral	0.70	deleterious	-2.21	low_impact	0.04	medium_impact	0.26	medium_impact	0.33	0.8	73.95	11.67	0.3	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9433	9433	A	T	MI.7112	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	227	76	Q	L	cAa/cTa	7.3	1	0	probably_damaging	0.96	neutral	0.67	neutral	2.24	neutral	-1.71	deleterious	-2.56	low_impact	1.75	0.48	damaging	0.09	damaging	3.75	23.30	deleterious	0.14	0.4	0.29	neutral	0.76	disease	0.39	neutral	0.53	disease	1	0.95	neutral	0.36	neutral	-2	neutral	0.75	deleterious	-2.21	low_impact	0.37	medium_impact	0.39	medium_impact	0.12	0.8	73.95	11.67	0.46	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9433	9433	A	C	MI.7113	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	227	76	Q	P	cAa/cCa	7.3	1	0	probably_damaging	0.99	neutral	0.22	neutral	2.19	neutral	-2.1	deleterious	-2.79	low_impact	1.78	0.45	damaging	0.04	damaging	3.30	22.90	deleterious	0.18	0.45	0.25	neutral	0.89	disease	0.61	disease	0.75	disease	5	0.99	deleterious	0.12	neutral	-2	neutral	0.81	deleterious	-2.81	low_impact	-0.12	medium_impact	0.41	medium_impact	0.18	0.8	73.95	11.67	0.45	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9433	9433	A	G	MI.7114	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	227	76	Q	R	cAa/cGa	7.3	1	0	probably_damaging	0.97	neutral	0.38	neutral	2.26	neutral	-0.62	neutral	-1.87	low_impact	1.88	0.47	damaging	0.06	damaging	3.41	23.00	deleterious	0.48	0.55	0.16	neutral	0.69	disease	0.48	neutral	0.49	neutral	0	0.97	neutral	0.21	neutral	-2	neutral	0.74	deleterious	-2.34	low_impact	0.07	medium_impact	0.5	medium_impact	0.12	0.8	73.95	11.67	0.52	P	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9434	9434	A	C	MI.7115	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	228	76	Q	H	caA/caC	6.84	1	0	probably_damaging	0.99	neutral	0.55	neutral	2.2	neutral	-2.01	deleterious	-2.5	medium_impact	2.68	0.56	damaging	0.04	damaging	3.25	22.80	deleterious	0.34	0.5	0.34	neutral	0.68	disease	0.34	neutral	0.53	disease	1	0.99	deleterious	0.28	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	0.24	medium_impact	1.22	medium_impact	0.34	0.8	73.95	11.67	0.42	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9434	9434	A	T	MI.7116	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	228	76	Q	H	caA/caT	6.84	1	0	probably_damaging	0.99	neutral	0.55	neutral	2.2	neutral	-2.01	deleterious	-2.5	medium_impact	2.68	0.56	damaging	0.04	damaging	3.46	23.00	deleterious	0.34	0.5	0.34	neutral	0.68	disease	0.34	neutral	0.53	disease	1	0.99	deleterious	0.28	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	0.24	medium_impact	1.22	medium_impact	0.34	0.8	73.95	11.67	0.44	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9435	9435	A	G	MI.7117	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	229	77	K	E	Aaa/Gaa	4.76	1	0	probably_damaging	0.94	neutral	0.3	neutral	2.23	neutral	-0.71	neutral	-2.16	medium_impact	2.2	0.67	neutral	0.59	neutral	3.67	23.30	deleterious	0.28	0.45	0.19	neutral	0.74	disease	0.46	neutral	0.52	disease	0	0.95	neutral	0.18	neutral	1	deleterious	0.69	deleterious	-2.03	low_impact	-0.02	medium_impact	0.79	medium_impact	0.44	0.8	75.1	11.08	0.56	P	0.95	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9435	9435	A	C	MI.7118	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	229	77	K	Q	Aaa/Caa	4.76	1	0	probably_damaging	0.93	neutral	0.31	neutral	2.18	neutral	-1.27	neutral	-2.06	low_impact	1.6	0.66	neutral	0.33	neutral	3.12	22.60	deleterious	0.55	0.6	0.24	neutral	0.51	disease	0.26	neutral	0.43	neutral	1	0.94	neutral	0.19	neutral	-2	neutral	0.65	deleterious	-1.96	low_impact	-0.01	medium_impact	0.25	medium_impact	0.28	0.8	75.1	11.08	0.52	P	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9436	9436	A	C	MI.7119	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	230	77	K	T	aAa/aCa	4.76	1	0	probably_damaging	0.98	neutral	0.41	neutral	2.16	neutral	-1.59	deleterious	-2.61	low_impact	1.34	0.69	neutral	0.27	damaging	2.31	18.20	deleterious	0.23	0.45	0.27	neutral	0.55	disease	0.28	neutral	0.44	neutral	1	0.98	neutral	0.22	neutral	-2	neutral	0.69	deleterious	-2.51	low_impact	0.1	medium_impact	0.02	medium_impact	0.14	0.8	75.1	11.08	0.46	N	0.87	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8863	8863	G	C	MI.712	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	337	113	V	L	Gtg/Ctg	-8.43	0	0	probably_damaging	0.98	neutral	0.52	neutral	4.5	neutral	0.72	neutral	-2.46	low_impact	1.42	0.75	neutral	0.58	neutral	3.57	23.10	deleterious	0.4	0.65	0.33	neutral	0.7	disease	0.41	neutral	0.42	neutral	2	0.98	neutral	0.27	neutral	-2	neutral	0.72	deleterious	-2.36	low_impact	0.31	medium_impact	0.12	medium_impact	0.75	0.9	42.04	7.9	0.28	N	0.70	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9436	9436	A	T	MI.7120	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	230	77	K	M	aAa/aTa	4.76	1	0	probably_damaging	0.99	neutral	0.23	neutral	2.1	deleterious	-3.37	deleterious	-2.93	low_impact	1.14	0.73	neutral	0.26	damaging	3.59	23.20	deleterious	0.2	0.45	0.53	disease	0.48	neutral	0.28	neutral	0.51	disease	0	0.99	deleterious	0.12	neutral	-2	neutral	0.72	deleterious	-2.81	low_impact	-0.11	medium_impact	-0.16	medium_impact	0.15	0.8	75.1	11.08	0.47	N	0.72	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9437	9437	A	C	MI.7121	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	231	77	K	N	aaA/aaC	8.69	1	0	probably_damaging	0.99	neutral	0.32	neutral	2.18	neutral	-1.34	neutral	-1.98	low_impact	1.38	0.66	neutral	0.22	damaging	2.62	20.30	deleterious	0.63	0.65	0.24	neutral	0.51	disease	0.29	neutral	0.44	neutral	1	0.99	deleterious	0.17	neutral	-2	neutral	0.70	deleterious	-2.81	low_impact	0.01	medium_impact	0.05	medium_impact	0.30	0.8	75.1	11.08	0.53	P	0.94	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9437	9437	A	T	MI.7122	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	231	77	K	N	aaA/aaT	8.69	1	0	probably_damaging	0.99	neutral	0.32	neutral	2.18	neutral	-1.34	neutral	-1.98	low_impact	1.38	0.66	neutral	0.22	damaging	2.80	21.30	deleterious	0.63	0.65	0.24	neutral	0.51	disease	0.29	neutral	0.44	neutral	1	0.99	deleterious	0.17	neutral	-2	neutral	0.70	deleterious	-2.81	low_impact	0.01	medium_impact	0.05	medium_impact	0.30	0.8	75.1	11.08	0.57	P	0.94	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9438	9438	G	A	MI.7123	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	232	78	G	S	Ggc/Agc	0.36	0.98	0	benign	0.1	neutral	0.41	neutral	2.03	neutral	-1.72	deleterious	-4.27	medium_impact	2.14	0.22	damaging	0.59	neutral	2.33	18.37	deleterious	0.23	0.45	0.18	neutral	0.82	disease	0.68	disease	0.53	disease	1	0.53	neutral	0.66	deleterious	-3	neutral	0.27	neutral	0.06	medium_impact	0.1	medium_impact	0.74	medium_impact	0.46	0.8	30.65	18.16	0.93	P	0.34	disease_causing_automatic	0	0.11	rs267606611	Pathogenic	Leber's_optic_atrophy	24690	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	.	2.97	G9438A	LHON	+	-	Conflicting reports	13	P	N	P,N	damaging
chrM	9438	9438	G	C	MI.7124	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	232	78	G	R	Ggc/Cgc	0.36	0.98	0	probably_damaging	0.98	neutral	0.36	neutral	1.93	deleterious	-3.41	deleterious	-6.15	high_impact	3.69	0.7	neutral	0.15	damaging	3.90	23.50	deleterious	0.09	0.4	0.33	neutral	0.93	disease	0.77	disease	0.83	disease	7	0.98	deleterious	0.19	neutral	2	deleterious	0.86	deleterious	-2.51	low_impact	0.05	medium_impact	2.12	high_impact	0.43	0.8	30.65	18.16	0.47	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9438	9438	G	T	MI.7125	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	232	78	G	C	Ggc/Tgc	0.36	0.98	0	probably_damaging	0.99	neutral	0.18	neutral	1.9	deleterious	-4.76	deleterious	-7.29	high_impact	3.58	0.66	neutral	0.16	damaging	4.06	23.70	deleterious	0.07	0.35	0.63	disease	0.93	disease	0.73	disease	0.8	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-2.81	low_impact	-0.18	medium_impact	2.03	high_impact	0.08	0.8	30.65	18.16	0.4	N	0.84	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9439	9439	G	C	MI.7126	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	233	78	G	A	gGc/gCc	1.98	1	0	benign	0.19	neutral	0.51	neutral	2.01	neutral	-1.88	deleterious	-4.78	medium_impact	3.23	0.74	neutral	0.34	neutral	1.41	12.82	neutral	0.29	0.45	0.18	neutral	0.82	disease	0.72	disease	0.72	disease	4	0.39	neutral	0.66	deleterious	-3	neutral	0.47	deleterious	-0.26	medium_impact	0.2	medium_impact	1.71	medium_impact	0.39	0.8	30.65	18.16	0.48	N	0.76	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9439	9439	G	T	MI.7127	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	233	78	G	V	gGc/gTc	1.98	1	0	probably_damaging	0.98	neutral	0.5	neutral	1.95	neutral	-2.88	deleterious	-7.32	high_impact	4.04	0.62	neutral	0.23	damaging	3.70	23.30	deleterious	0.08	0.35	0.32	neutral	0.94	disease	0.74	disease	0.83	disease	7	0.98	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-2.51	low_impact	0.19	medium_impact	2.44	high_impact	0.12	0.8	30.65	18.16	0.46	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9439	9439	G	A	MI.7128	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	233	78	G	D	gGc/gAc	1.98	1	0	probably_damaging	0.91	neutral	0.21	neutral	1.93	deleterious	-3.28	deleterious	-5.21	high_impact	4.38	0.67	neutral	0.2	damaging	3.84	23.40	deleterious	0.09	0.35	0.33	neutral	0.93	disease	0.78	disease	0.8	disease	6	0.94	neutral	0.15	neutral	2	deleterious	0.74	deleterious	-1.85	low_impact	-0.14	medium_impact	2.74	high_impact	0.17	0.8	30.65	18.16	0.57	P	0.91	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9441	9441	C	G	MI.7129	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	235	79	L	V	Ctt/Gtt	-7.28	0	0	probably_damaging	0.91	neutral	0.55	neutral	1.95	neutral	-2.03	deleterious	-2.56	medium_impact	2.6	0.55	damaging	0.01	damaging	3.39	23.00	deleterious	0.28	0.45	0.22	neutral	0.78	disease	0.64	disease	0.68	disease	4	0.9	neutral	0.32	neutral	1	deleterious	0.72	deleterious	-1.85	low_impact	0.24	medium_impact	1.15	medium_impact	0.34	0.8	74.71	11.52	0.19	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8863	8863	G	A	MI.713	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	337	113	V	M	Gtg/Atg	-8.43	0	0	probably_damaging	1	neutral	0.6	neutral	4.28	neutral	-1.37	deleterious	-2.57	low_impact	1.52	0.77	neutral	0.54	neutral	3.66	23.20	deleterious	0.32	0.65	0.5	disease	0.52	disease	0.39	neutral	0.39	neutral	2	1	deleterious	0.3	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.39	medium_impact	0.21	medium_impact	0.81	0.9	42.04	7.9	0.21	N	0.96	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9441	9441	C	T	MI.7130	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	235	79	L	F	Ctt/Ttt	-7.28	0	0	probably_damaging	0.99	neutral	0.73	neutral	1.93	neutral	-2.23	deleterious	-3.5	low_impact	1.84	0.57	damaging	0.02	damaging	3.92	23.50	deleterious	0.29	0.45	0.26	neutral	0.76	disease	0.64	disease	0.55	disease	1	0.99	deleterious	0.37	neutral	-2	neutral	0.78	deleterious	-2.81	low_impact	0.44	medium_impact	0.47	medium_impact	0.51	0.8	74.71	11.52	0.19	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9441	9441	C	A	MI.7131	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	235	79	L	I	Ctt/Att	-7.28	0	0	probably_damaging	0.96	neutral	0.46	neutral	1.98	neutral	-1.74	neutral	-1.75	medium_impact	2.34	0.49	damaging	0.07	damaging	4.07	23.70	deleterious	0.3	0.45	0.23	neutral	0.64	disease	0.31	neutral	0.43	neutral	1	0.96	neutral	0.25	neutral	1	deleterious	0.71	deleterious	-2.21	low_impact	0.15	medium_impact	0.92	medium_impact	0.42	0.8	74.71	11.52	0.29	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9442	9442	T	A	MI.7132	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	236	79	L	H	cTt/cAt	-0.33	0	0	probably_damaging	1	neutral	0.55	neutral	1.82	deleterious	-5.1	deleterious	-6.19	medium_impact	3.11	0.58	damaging	0.02	damaging	4.01	23.60	deleterious	0.06	0.35	0.43	neutral	0.86	disease	0.64	disease	0.67	disease	3	1	deleterious	0.28	neutral	1	deleterious	0.83	deleterious	-3.78	low_impact	0.24	medium_impact	1.61	medium_impact	0.15	0.8	74.71	11.52	0.22	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9442	9442	T	G	MI.7133	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	236	79	L	R	cTt/cGt	-0.33	0	0	probably_damaging	0.99	neutral	0.38	neutral	1.83	deleterious	-4.4	deleterious	-5.25	medium_impact	2.47	0.71	neutral	0.02	damaging	4.12	23.80	deleterious	0.03	0.35	0.25	neutral	0.93	disease	0.75	disease	0.79	disease	6	0.99	deleterious	0.2	neutral	1	deleterious	0.85	deleterious	-2.81	low_impact	0.07	medium_impact	1.03	medium_impact	0.11	0.8	74.71	11.52	0.23	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9442	9442	T	C	MI.7134	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	236	79	L	P	cTt/cCt	-0.33	0	0	probably_damaging	1	neutral	0.21	neutral	1.83	deleterious	-4.25	deleterious	-6.19	medium_impact	3.17	0.56	damaging	0.02	damaging	3.74	23.30	deleterious	0.03	0.35	0.32	neutral	0.87	disease	0.42	neutral	0.65	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.84	deleterious	-3.78	low_impact	-0.14	medium_impact	1.66	medium_impact	0.15	0.8	74.71	11.52	0.26	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9444	9444	C	G	MI.7135	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	238	80	R	G	Cga/Gga	-7.97	0	0	probably_damaging	0.97	neutral	0.34	neutral	2.15	neutral	-2.91	deleterious	-6.32	high_impact	3.54	0.63	neutral	0.01	damaging	4.14	23.80	deleterious	0.08	0.35	0.3	neutral	0.81	disease	0.68	disease	0.7	disease	4	0.97	neutral	0.19	neutral	2	deleterious	0.76	deleterious	-2.34	low_impact	0.03	medium_impact	1.99	medium_impact	0.16	0.8	73.95	11.62	0.26	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9444	9444	C	T	MI.7136	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	238	80	R	W	Cga/Tga	-7.97	0	0	probably_damaging	1	neutral	0.18	neutral	2.11	deleterious	-4.72	deleterious	-7.25	high_impact	3.81	0.67	neutral	0.02	damaging	5.07	25.30	deleterious	0.1	0.4	0.67	disease	0.9	disease	0.67	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.18	medium_impact	2.23	high_impact	0.61	0.8	73.95	11.62	0.31	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9445	9445	G	A	MI.7137	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	239	80	R	Q	cGa/cAa	2.44	0.97	0	probably_damaging	0.94	neutral	0.3	neutral	2.2	neutral	-1.87	deleterious	-3.48	medium_impact	2.65	0.59	damaging	0.03	damaging	4.38	24.10	deleterious	0.28	0.45	0.2	neutral	0.79	disease	0.46	neutral	0.52	disease	0	0.95	neutral	0.18	neutral	1	deleterious	0.73	deleterious	-2.03	low_impact	-0.02	medium_impact	1.19	medium_impact	0.77	0.85	73.95	11.62	0.39	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	COSM6716218	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9445	9445	G	C	MI.7138	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	239	80	R	P	cGa/cCa	2.44	0.97	0	probably_damaging	0.99	neutral	0.21	neutral	2.13	deleterious	-3.54	deleterious	-6.23	high_impact	4	0.61	neutral	0.03	damaging	4.15	23.80	deleterious	0.02	0.35	0.38	neutral	0.92	disease	0.68	disease	0.74	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.14	medium_impact	2.4	high_impact	0.09	0.8	73.95	11.62	0.37	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9445	9445	G	T	MI.7139	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	239	80	R	L	cGa/cTa	2.44	0.97	0	probably_damaging	0.93	neutral	0.66	neutral	2.16	neutral	-2.52	deleterious	-6.32	medium_impact	2.73	0.63	neutral	0.02	damaging	4.26	23.90	deleterious	0.09	0.35	0.21	neutral	0.91	disease	0.65	disease	0.73	disease	5	0.92	neutral	0.37	neutral	1	deleterious	0.78	deleterious	-1.96	low_impact	0.36	medium_impact	1.26	medium_impact	0.00	0.8	73.95	11.62	0.3	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8863	8863	G	T	MI.714	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	337	113	V	L	Gtg/Ttg	-8.43	0	0	probably_damaging	0.98	neutral	0.52	neutral	4.5	neutral	0.72	neutral	-2.46	low_impact	1.42	0.75	neutral	0.58	neutral	3.67	23.20	deleterious	0.4	0.65	0.33	neutral	0.7	disease	0.41	neutral	0.42	neutral	2	0.98	neutral	0.27	neutral	-2	neutral	0.72	deleterious	-2.36	low_impact	0.31	medium_impact	0.12	medium_impact	0.75	0.9	42.04	7.9	0.28	N	0.70	polymorphism	0.99	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9447	9447	T	G	MI.7140	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	241	81	Y	D	Tac/Gac	-2.88	0	0	probably_damaging	1	neutral	0.2	neutral	2.5	deleterious	-3.36	deleterious	-6.33	medium_impact	2.89	0.61	neutral	0.41	neutral	3.90	23.50	deleterious	0.03	0.35	0.44	neutral	0.83	disease	0.71	disease	0.77	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	-0.15	medium_impact	1.41	medium_impact	0.13	0.8	73.95	11.7	0.31	N	0.99	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9447	9447	T	A	MI.7141	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	241	81	Y	N	Tac/Aac	-2.88	0	0	probably_damaging	1	neutral	0.28	neutral	2.5	neutral	-2.52	deleterious	-5.89	medium_impact	2.75	0.63	neutral	0.42	neutral	3.98	23.60	deleterious	0.07	0.35	0.34	neutral	0.76	disease	0.55	disease	0.71	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	-0.04	medium_impact	1.28	medium_impact	0.11	0.8	73.95	11.7	0.34	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9447	9447	T	C	MI.7142	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	241	81	Y	H	Tac/Cac	-2.88	0	0	probably_damaging	0.99	neutral	0.49	neutral	2.5	neutral	-2.8	deleterious	-3.56	medium_impact	3.44	0.62	neutral	0.44	neutral	3.51	23.10	deleterious	0.14	0.4	0.4	neutral	0.69	disease	0.63	disease	0.7	disease	4	0.99	deleterious	0.25	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	0.18	medium_impact	1.9	medium_impact	0.11	0.8	73.95	11.7	0.33	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9448	9448	A	T	MI.7143	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	242	81	Y	F	tAc/tTc	7.53	1	0	probably_damaging	0.93	neutral	0.67	neutral	2.62	neutral	-0.02	neutral	-1.9	neutral_impact	0.7	0.65	neutral	0.76	neutral	3.18	22.70	deleterious	0.25	0.45	0.19	neutral	0.57	disease	0.39	neutral	0.45	neutral	1	0.92	neutral	0.37	neutral	-2	neutral	0.68	deleterious	-1.96	low_impact	0.37	medium_impact	-0.56	medium_impact	0.38	0.8	73.95	11.7	0.53	P	0.72	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9448	9448	A	C	MI.7144	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	242	81	Y	S	tAc/tCc	7.53	1	0	probably_damaging	0.99	neutral	0.39	neutral	2.55	neutral	-0.93	deleterious	-5.42	medium_impact	2.54	0.66	neutral	0.46	neutral	3.58	23.20	deleterious	0.06	0.35	0.14	neutral	0.74	disease	0.61	disease	0.66	disease	3	0.99	deleterious	0.2	neutral	1	deleterious	0.74	deleterious	-2.81	low_impact	0.08	medium_impact	1.09	medium_impact	0.20	0.8	73.95	11.7	0.44	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9448	9448	A	G	MI.7145	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	242	81	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	neutral	0.16	neutral	2.49	neutral	-2.66	deleterious	-5.11	medium_impact	3.09	0.66	neutral	0.44	neutral	3.37	22.90	deleterious	0.05	0.35	0.4	neutral	0.83	disease	0.66	disease	0.74	disease	5	1	deleterious	0.08	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	-0.22	medium_impact	1.59	medium_impact	0.08	0.8	73.95	11.7	0.48	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9450	9450	G	C	MI.7146	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	244	82	G	R	Ggg/Cgg	-6.81	0	0	probably_damaging	1	neutral	0.35	neutral	1.64	deleterious	-6.11	deleterious	-7.42	high_impact	4.39	0.67	neutral	0.02	damaging	3.90	23.50	deleterious	0.02	0.35	0.89	disease	0.91	disease	0.83	disease	0.85	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.94	deleterious	-3.78	low_impact	0.04	medium_impact	2.75	high_impact	0.61	0.8	74.33	11.59	0.44	N	0.99	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9450	9450	G	T	MI.7147	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	244	82	G	W	Ggg/Tgg	-6.81	0	0	probably_damaging	1	neutral	0.19	neutral	1.63	deleterious	-8.07	deleterious	-7.42	high_impact	4.2	0.64	neutral	0.02	damaging	4.36	24.10	deleterious	0.03	0.35	0.97	disease	0.92	disease	0.77	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.93	deleterious	-3.78	low_impact	-0.17	medium_impact	2.58	high_impact	0.17	0.8	74.33	11.59	0.34	N	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9451	9451	G	A	MI.7148	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	245	82	G	E	gGg/gAg	6.14	1	0	probably_damaging	1	neutral	0.27	neutral	1.65	deleterious	-5.85	deleterious	-7.41	high_impact	4.75	0.57	damaging	0.01	damaging	3.80	23.40	deleterious	0.02	0.35	0.86	disease	0.9	disease	0.82	disease	0.86	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.92	deleterious	-3.78	low_impact	-0.06	medium_impact	3.07	high_impact	0.28	0.8	74.33	11.59	0.69	P	1.00	polymorphism	1	0.46	.	.	.	.	.	.	COSM6716220	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9451	9451	G	C	MI.7149	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	245	82	G	A	gGg/gCg	6.14	1	0	probably_damaging	1	neutral	0.5	neutral	1.86	neutral	-2.38	deleterious	-5.56	medium_impact	3.39	0.58	damaging	0.02	damaging	3.05	22.40	deleterious	0.06	0.35	0.73	disease	0.78	disease	0.73	disease	0.71	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.88	deleterious	-3.78	low_impact	0.19	medium_impact	1.86	medium_impact	0.52	0.8	74.33	11.59	0.47	N	0.30	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8864	8864	T	A	MI.715	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	338	113	V	E	gTg/gAg	4.06	1	0	probably_damaging	1	deleterious	0.03	neutral	4.23	neutral	-2.83	deleterious	-5.42	medium_impact	3.25	0.77	neutral	0.44	neutral	4.77	24.70	deleterious	0.15	0.65	0.75	disease	0.92	disease	0.73	disease	0.77	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.86	deleterious	-3.6	low_impact	-0.56	medium_impact	1.69	medium_impact	0.57	0.9	42.04	7.9	0.44	N	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9451	9451	G	T	MI.7150	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	245	82	G	V	gGg/gTg	6.14	1	0	probably_damaging	1	neutral	0.5	neutral	1.66	deleterious	-5.16	deleterious	-8.34	high_impact	4.39	0.54	damaging	0.01	damaging	3.70	23.30	deleterious	0.02	0.35	0.88	disease	0.93	disease	0.77	disease	0.85	disease	7	1	deleterious	0.25	neutral	2	deleterious	0.93	deleterious	-3.78	low_impact	0.19	medium_impact	2.75	high_impact	0.23	0.8	74.33	11.59	0.59	P	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9453	9453	A	G	MI.7151	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	247	83	M	V	Ata/Gta	-15.84	0	0	possibly_damaging	0.84	neutral	0.65	neutral	2.41	neutral	-2.01	deleterious	-3.67	medium_impact	2.52	0.45	damaging	0.07	damaging	2.77	21.20	deleterious	0.18	0.45	0.13	neutral	0.86	disease	0.53	disease	0.5	disease	0	0.81	neutral	0.41	neutral	0	NA	0.66	deleterious	-1.57	low_impact	0.35	medium_impact	1.08	medium_impact	0.39	0.8	74.33	11.59	0.26	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9453	9453	A	C	MI.7152	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	247	83	M	L	Ata/Cta	-15.84	0	0	possibly_damaging	0.77	neutral	0.87	neutral	2.47	neutral	-1.88	deleterious	-2.75	medium_impact	2.8	0.57	damaging	0.04	damaging	3.29	22.80	deleterious	0.18	0.45	0.13	neutral	0.88	disease	0.65	disease	0.72	disease	4	0.73	neutral	0.55	deleterious	0	NA	0.57	deleterious	-1.38	low_impact	0.66	medium_impact	1.33	medium_impact	0.38	0.8	74.33	11.59	0.22	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9453	9453	A	T	MI.7153	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	247	83	M	L	Ata/Tta	-15.84	0	0	possibly_damaging	0.77	neutral	0.87	neutral	2.47	neutral	-1.88	deleterious	-2.75	medium_impact	2.8	0.57	damaging	0.04	damaging	3.40	23.00	deleterious	0.18	0.45	0.13	neutral	0.88	disease	0.65	disease	0.72	disease	4	0.73	neutral	0.55	deleterious	0	NA	0.57	deleterious	-1.38	low_impact	0.66	medium_impact	1.33	medium_impact	0.38	0.8	74.33	11.59	0.22	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9454	9454	T	A	MI.7154	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	248	83	M	K	aTa/aAa	6.84	1	0	probably_damaging	0.93	neutral	0.3	neutral	2.32	deleterious	-4.65	deleterious	-5.51	high_impact	3.97	0.65	neutral	0.03	damaging	3.92	23.50	deleterious	0.02	0.35	0.36	neutral	0.95	disease	0.76	disease	0.87	disease	7	0.94	neutral	0.19	neutral	2	deleterious	0.83	deleterious	-1.96	low_impact	-0.02	medium_impact	2.38	high_impact	0.21	0.8	74.33	11.59	0.53	P	0.99	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9454	9454	T	C	MI.7155	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	248	83	M	T	aTa/aCa	6.84	1	0	probably_damaging	0.96	neutral	0.31	neutral	2.36	neutral	-2.1	deleterious	-5.51	medium_impact	2.6	0.6	damaging	0.06	damaging	2.93	22.00	deleterious	0.05	0.35	0.16	neutral	0.91	disease	0.69	disease	0.74	disease	5	0.97	neutral	0.18	neutral	1	deleterious	0.80	deleterious	-2.21	low_impact	-0.01	medium_impact	1.15	medium_impact	0.15	0.8	74.33	11.59	0.36	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9455	9455	A	C	MI.7156	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	249	83	M	I	atA/atC	5.91	1	0	possibly_damaging	0.88	neutral	0.96	neutral	2.4	neutral	-2.15	deleterious	-3.67	medium_impact	3.1	0.51	damaging	0.05	damaging	3.39	23.00	deleterious	0.12	0.4	0.11	neutral	0.89	disease	0.63	disease	0.66	disease	3	0.88	neutral	0.54	deleterious	0	NA	0.70	deleterious	-1.71	low_impact	0.98	medium_impact	1.6	medium_impact	0.45	0.8	74.33	11.59	0.45	N	0.95	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9455	9455	A	T	MI.7157	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	249	83	M	I	atA/atT	5.91	1	0	possibly_damaging	0.88	neutral	0.96	neutral	2.4	neutral	-2.15	deleterious	-3.67	medium_impact	3.1	0.51	damaging	0.05	damaging	3.46	23.00	deleterious	0.12	0.4	0.11	neutral	0.89	disease	0.63	disease	0.66	disease	3	0.88	neutral	0.54	deleterious	0	NA	0.70	deleterious	-1.71	low_impact	0.98	medium_impact	1.6	medium_impact	0.45	0.8	74.33	11.59	0.46	N	0.95	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9456	9456	A	C	MI.7158	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	250	84	I	L	Atc/Ctc	1.52	0.97	0	benign	0.01	neutral	0.64	neutral	2.55	neutral	-0.53	neutral	-1.4	medium_impact	1.97	0.59	damaging	0.71	neutral	1.80	15.00	deleterious	0.23	0.45	0.13	neutral	0.65	disease	0.36	neutral	0.45	neutral	1	0.35	neutral	0.82	deleterious	-3	neutral	0.16	neutral	1.07	medium_impact	0.33	medium_impact	0.58	medium_impact	0.64	0.8	18.39	29.81	0.42	N	0.53	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9456	9456	A	G	MI.7159	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	250	84	I	V	Atc/Gtc	1.52	0.97	0	benign	0	neutral	0.3	neutral	2.49	neutral	-0.61	neutral	-0.48	low_impact	1.21	0.71	neutral	0.93	neutral	-0.11	1.64	neutral	0.36	0.5	0.19	neutral	0.52	disease	0.36	neutral	0.43	neutral	1	0.7	neutral	0.65	deleterious	-6	neutral	0.14	neutral	2.05	high_impact	-0.02	medium_impact	-0.1	medium_impact	0.48	0.8	18.39	29.81	0.53	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8864	8864	T	G	MI.716	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	338	113	V	G	gTg/gGg	4.06	1	0	probably_damaging	1	neutral	0.17	neutral	4.23	neutral	-2.94	deleterious	-6.29	high_impact	3.81	0.73	neutral	0.58	neutral	3.75	23.30	deleterious	0.14	0.65	0.77	disease	0.86	disease	0.64	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.6	low_impact	-0.1	medium_impact	2.17	high_impact	0.54	0.9	42.04	7.9	0.48	N	0.93	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9456	9456	A	T	MI.7160	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	250	84	I	F	Atc/Ttc	1.52	0.97	0	benign	0.1	neutral	1	neutral	2.42	neutral	-2.1	deleterious	-3.1	medium_impact	2.66	0.63	neutral	0.47	neutral	1.90	15.61	deleterious	0.13	0.4	0.33	neutral	0.87	disease	0.54	disease	0.65	disease	3	0.1	neutral	0.95	deleterious	-3	neutral	0.30	neutral	0.06	medium_impact	1.9	high_impact	1.2	medium_impact	0.61	0.8	18.39	29.81	0.38	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9457	9457	T	C	MI.7161	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	251	84	I	T	aTc/aCc	0.13	0.91	0	benign	0	neutral	0.13	neutral	2.43	neutral	-1.8	deleterious	-3.13	medium_impact	2.8	0.62	neutral	0.56	neutral	1.44	12.98	neutral	0.07	0.35	0.25	neutral	0.81	disease	0.58	disease	0.63	disease	3	0.87	neutral	0.57	deleterious	-3	neutral	0.23	neutral	2.05	high_impact	-0.28	medium_impact	1.33	medium_impact	0.28	0.8	18.39	29.81	0.41	N	0.28	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9457	9457	T	G	MI.7162	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	251	84	I	S	aTc/aGc	0.13	0.91	0	benign	0.06	neutral	0.13	neutral	2.44	neutral	-1.02	deleterious	-4.05	medium_impact	2.48	0.67	neutral	0.4	neutral	2.43	19.04	deleterious	0.03	0.35	0.34	neutral	0.9	disease	0.61	disease	0.68	disease	4	0.86	neutral	0.54	deleterious	-3	neutral	0.30	neutral	0.29	medium_impact	-0.28	medium_impact	1.04	medium_impact	0.27	0.8	18.39	29.81	0.35	N	0.74	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9457	9457	T	A	MI.7163	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	251	84	I	N	aTc/aAc	0.13	0.91	0	benign	0.15	neutral	0.1	neutral	2.4	deleterious	-3.49	deleterious	-5.19	high_impact	3.87	0.61	neutral	0.34	neutral	2.88	21.80	deleterious	0.07	0.35	0.51	disease	0.91	disease	0.54	disease	0.71	disease	4	0.89	neutral	0.48	deleterious	-2	neutral	0.48	deleterious	-0.14	medium_impact	-0.35	medium_impact	2.29	high_impact	0.28	0.8	18.39	29.81	0.39	N	0.83	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9458	9458	C	A	MI.7164	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	252	84	I	M	atC/atA	4.76	0.97	0	benign	0.25	neutral	0.61	neutral	2.41	neutral	-1.95	neutral	-2.09	medium_impact	2.58	0.7	neutral	0.58	neutral	1.89	15.52	deleterious	0.17	0.45	0.28	neutral	0.7	disease	0.5	neutral	0.51	disease	0	0.28	neutral	0.68	deleterious	-3	neutral	0.25	neutral	-0.41	medium_impact	0.3	medium_impact	1.13	medium_impact	0.50	0.8	18.39	29.81	0.47	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9458	9458	C	G	MI.7165	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	252	84	I	M	atC/atG	4.76	0.97	0	benign	0.25	neutral	0.61	neutral	2.41	neutral	-1.95	neutral	-2.09	medium_impact	2.58	0.7	neutral	0.58	neutral	1.42	12.90	neutral	0.17	0.45	0.28	neutral	0.7	disease	0.5	neutral	0.51	disease	0	0.28	neutral	0.68	deleterious	-3	neutral	0.25	neutral	-0.41	medium_impact	0.3	medium_impact	1.13	medium_impact	0.50	0.8	18.39	29.81	0.48	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9459	9459	C	G	MI.7166	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	253	85	L	V	Cta/Gta	-5.66	0	0	probably_damaging	0.96	neutral	0.14	neutral	1.65	neutral	-2.62	deleterious	-2.75	medium_impact	2.29	0.51	damaging	0.01	damaging	3.32	22.90	deleterious	0.22	0.45	0.25	neutral	0.82	disease	0.63	disease	0.68	disease	4	0.98	neutral	0.09	neutral	1	deleterious	0.76	deleterious	-2.21	low_impact	-0.26	medium_impact	0.87	medium_impact	0.62	0.8	73.18	11.63	0.25	N	0.81	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9459	9459	C	A	MI.7167	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	253	85	L	M	Cta/Ata	-5.66	0	0	probably_damaging	1	neutral	0.21	neutral	1.57	deleterious	-3.51	neutral	-1.82	medium_impact	2.54	0.56	damaging	0.05	damaging	3.63	23.20	deleterious	0.23	0.45	0.35	neutral	0.64	disease	0.55	disease	0.45	neutral	1	1	deleterious	0.11	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	-0.14	medium_impact	1.09	medium_impact	0.41	0.8	73.18	11.63	0.27	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9460	9460	T	A	MI.7168	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	254	85	L	Q	cTa/cAa	-0.33	0	0	probably_damaging	1	deleterious	0.02	neutral	1.5	deleterious	-5.79	deleterious	-5.5	high_impact	4.49	0.59	damaging	0.03	damaging	4.00	23.60	deleterious	0.02	0.35	0.58	disease	0.88	disease	0.61	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.78	low_impact	-0.77	medium_impact	2.84	high_impact	0.42	0.8	73.18	11.63	0.36	N	0.97	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9460	9460	T	G	MI.7169	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	254	85	L	R	cTa/cGa	-0.33	0	0	probably_damaging	1	neutral	0.09	neutral	1.5	deleterious	-5.74	deleterious	-5.5	high_impact	4.49	0.66	neutral	0.02	damaging	4.11	23.70	deleterious	0.02	0.35	0.56	disease	0.95	disease	0.75	disease	0.88	disease	8	1	deleterious	0.05	neutral	2	deleterious	0.90	deleterious	-3.78	low_impact	-0.38	medium_impact	2.84	high_impact	0.27	0.8	73.18	11.63	0.44	N	0.99	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8864	8864	T	C	MI.717	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	338	113	V	A	gTg/gCg	4.06	1	0	probably_damaging	0.99	neutral	0.09	neutral	4.28	neutral	-1.25	deleterious	-3.43	medium_impact	3.46	0.81	neutral	0.62	neutral	3.52	23.10	deleterious	0.35	0.65	0.41	neutral	0.72	disease	0.61	disease	0.65	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.74	deleterious	-2.65	low_impact	-0.28	medium_impact	1.87	medium_impact	0.51	0.9	42.04	7.9	0.48	N	0.60	disease_causing	0.98	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9460	9460	T	C	MI.7170	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	254	85	L	P	cTa/cCa	-0.33	0	0	probably_damaging	1	deleterious	0.01	neutral	1.49	deleterious	-6.52	deleterious	-6.42	high_impact	3.8	0.48	damaging	0.03	damaging	3.84	23.40	deleterious	0.02	0.35	0.6	disease	0.89	disease	0.6	disease	0.67	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.78	low_impact	-0.95	medium_impact	2.22	high_impact	0.45	0.8	73.18	11.63	0.28	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9462	9462	T	C	MI.7171	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	256	86	F	L	Ttt/Ctt	-7.51	0	0	probably_damaging	0.95	neutral	1	neutral	1.48	deleterious	-4.47	deleterious	-5.45	high_impact	3.64	0.65	neutral	0.03	damaging	3.88	23.50	deleterious	0.05	0.35	0.32	neutral	0.88	disease	0.73	disease	0.73	disease	5	0.95	neutral	0.53	deleterious	2	deleterious	0.78	deleterious	-2.11	low_impact	1.9	high_impact	2.08	high_impact	0.64	0.8	73.56	11.56	0.22	N	0.92	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9462	9462	T	A	MI.7172	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	256	86	F	I	Ttt/Att	-7.51	0	0	probably_damaging	0.97	neutral	0.86	neutral	1.41	deleterious	-5.06	deleterious	-5.45	high_impact	4.39	0.69	neutral	0.02	damaging	4.28	24.00	deleterious	0.07	0.35	0.35	neutral	0.92	disease	0.73	disease	0.76	disease	5	0.96	neutral	0.45	neutral	2	deleterious	0.81	deleterious	-2.34	low_impact	0.64	medium_impact	2.75	high_impact	0.51	0.8	73.56	11.56	0.32	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9462	9462	T	G	MI.7173	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	256	86	F	V	Ttt/Gtt	-7.51	0	0	probably_damaging	0.98	neutral	0.31	neutral	1.41	deleterious	-5.36	deleterious	-6.35	high_impact	4.19	0.66	neutral	0.02	damaging	3.86	23.50	deleterious	0.05	0.35	0.41	neutral	0.94	disease	0.77	disease	0.84	disease	7	0.99	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-2.51	low_impact	-0.01	medium_impact	2.57	high_impact	0.43	0.8	73.56	11.56	0.38	N	0.97	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9463	9463	T	A	MI.7174	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	257	86	F	Y	tTt/tAt	5.91	1	0	probably_damaging	0.95	neutral	0.16	neutral	1.46	deleterious	-3.57	deleterious	-2.72	high_impact	4.04	0.71	neutral	0.03	damaging	4.25	23.90	deleterious	0.09	0.35	0.4	neutral	0.89	disease	0.73	disease	0.76	disease	5	0.97	neutral	0.11	neutral	2	deleterious	0.80	deleterious	-2.11	low_impact	-0.22	medium_impact	2.44	high_impact	0.62	0.8	73.56	11.56	0.59	P	0.80	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9463	9463	T	G	MI.7175	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	257	86	F	C	tTt/tGt	5.91	1	0	probably_damaging	1	deleterious	0.03	neutral	1.35	deleterious	-7.81	deleterious	-7.27	high_impact	4.74	0.72	neutral	0.02	damaging	4.01	23.60	deleterious	0.02	0.35	0.78	disease	0.92	disease	0.78	disease	0.8	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.86	deleterious	-3.78	low_impact	-0.67	medium_impact	3.07	high_impact	0.29	0.8	73.56	11.56	0.59	P	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9463	9463	T	C	MI.7176	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	257	86	F	S	tTt/tCt	5.91	1	0	probably_damaging	0.99	neutral	0.25	neutral	1.38	deleterious	-6.41	deleterious	-7.25	high_impact	4.04	0.72	neutral	0.02	damaging	4.22	23.90	deleterious	0.02	0.35	0.59	disease	0.92	disease	0.75	disease	0.8	disease	6	0.99	deleterious	0.13	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.08	medium_impact	2.44	high_impact	0.37	0.8	73.56	11.56	0.53	N	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9464	9464	T	A	MI.7177	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	258	86	F	L	ttT/ttA	7.53	1	0	probably_damaging	0.95	neutral	1	neutral	1.48	deleterious	-4.47	deleterious	-5.45	high_impact	3.64	0.65	neutral	0.03	damaging	4.39	24.10	deleterious	0.05	0.35	0.32	neutral	0.88	disease	0.73	disease	0.73	disease	5	0.95	neutral	0.53	deleterious	2	deleterious	0.78	deleterious	-2.11	low_impact	1.9	high_impact	2.08	high_impact	0.64	0.8	73.56	11.56	0.47	N	0.92	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9464	9464	T	G	MI.7178	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	258	86	F	L	ttT/ttG	7.53	1	0	probably_damaging	0.95	neutral	1	neutral	1.48	deleterious	-4.47	deleterious	-5.45	high_impact	3.64	0.65	neutral	0.03	damaging	4.28	24.00	deleterious	0.05	0.35	0.32	neutral	0.88	disease	0.73	disease	0.73	disease	5	0.95	neutral	0.53	deleterious	2	deleterious	0.78	deleterious	-2.11	low_impact	1.9	high_impact	2.08	high_impact	0.64	0.8	73.56	11.56	0.46	N	0.92	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9465	9465	A	G	MI.7179	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	259	87	I	V	Att/Gtt	-3.11	0	0	possibly_damaging	0.79	neutral	0.31	neutral	2.06	neutral	-2.3	neutral	-0.91	medium_impact	3.07	0.53	damaging	0.08	damaging	3.00	22.20	deleterious	0.31	0.45	0.18	neutral	0.61	disease	0.67	disease	0.44	neutral	1	0.82	neutral	0.26	neutral	0	NA	0.51	deleterious	-1.43	low_impact	-0.01	medium_impact	1.57	medium_impact	0.64	0.8	74.33	11.54	0.31	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8866	8866	A	G	MI.718	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	340	114	I	V	Att/Gtt	-3.8	0	0	benign	0	neutral	0.11	neutral	4.22	neutral	-1.27	neutral	-0.39	low_impact	1.47	0.93	neutral	0.98	neutral	-0.14	1.44	neutral	0.52	0.65	0.61	disease	0.44	neutral	0.39	neutral	0.6	disease	2	0.89	neutral	0.56	deleterious	-6	neutral	0.16	neutral	2.09	high_impact	-0.22	medium_impact	0.16	medium_impact	0.50	0.9	18.14	12.08	0.39	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	COSM1331623	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9465	9465	A	C	MI.7180	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	259	87	I	L	Att/Ctt	-3.11	0	0	probably_damaging	0.91	neutral	0.59	neutral	2.52	neutral	-0.16	neutral	-1.82	low_impact	1.7	0.59	damaging	0.04	damaging	3.73	23.30	deleterious	0.17	0.45	0.11	neutral	0.78	disease	0.67	disease	0.63	disease	3	0.9	neutral	0.34	neutral	-2	neutral	0.54	deleterious	-1.85	low_impact	0.28	medium_impact	0.34	medium_impact	0.55	0.8	74.33	11.54	0.22	N	0.83	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9465	9465	A	T	MI.7181	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	259	87	I	F	Att/Ttt	-3.11	0	0	probably_damaging	0.98	neutral	1	neutral	1.93	deleterious	-4.5	deleterious	-3.63	high_impact	4.04	0.57	damaging	0.02	damaging	3.65	23.20	deleterious	0.03	0.35	0.54	disease	0.89	disease	0.77	disease	0.79	disease	6	0.98	deleterious	0.51	deleterious	2	deleterious	0.83	deleterious	-2.51	low_impact	1.9	high_impact	2.44	high_impact	0.63	0.8	74.33	11.54	0.3	N	0.94	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9466	9466	T	C	MI.7182	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	260	87	I	T	aTt/aCt	8.69	1	0	probably_damaging	0.99	neutral	0.33	neutral	1.91	deleterious	-5.89	deleterious	-4.53	high_impact	4.04	0.57	damaging	0.02	damaging	3.24	22.80	deleterious	0.02	0.35	0.6	disease	0.82	disease	0.74	disease	0.76	disease	5	0.99	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-2.81	low_impact	0.02	medium_impact	2.44	high_impact	0.26	0.8	74.33	11.54	0.51	N	0.91	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9466	9466	T	G	MI.7183	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	260	87	I	S	aTt/aGt	8.69	1	0	probably_damaging	0.99	neutral	0.64	neutral	1.9	deleterious	-7.38	deleterious	-5.43	high_impact	4.59	0.61	neutral	0.06	damaging	4.15	23.80	deleterious	0.01	0.35	0.73	disease	0.9	disease	0.73	disease	0.78	disease	6	0.99	deleterious	0.33	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	0.33	medium_impact	2.93	high_impact	0.29	0.8	74.33	11.54	0.55	P	0.93	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9466	9466	T	A	MI.7184	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	260	87	I	N	aTt/aAt	8.69	1	0	probably_damaging	1	neutral	0.24	neutral	1.9	deleterious	-8.23	deleterious	-6.35	high_impact	4.59	0.58	damaging	0.02	damaging	4.22	23.90	deleterious	0.02	0.35	0.84	disease	0.91	disease	0.77	disease	0.81	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.09	medium_impact	2.93	high_impact	0.33	0.8	74.33	11.54	0.58	P	0.97	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9467	9467	T	A	MI.7185	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	261	87	I	M	atT/atA	5.91	1	0	probably_damaging	0.99	neutral	0.1	neutral	1.98	deleterious	-3.39	deleterious	-2.72	high_impact	4.25	0.61	neutral	0.02	damaging	3.60	23.20	deleterious	0.07	0.35	0.49	neutral	0.77	disease	0.74	disease	0.74	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.75	deleterious	-2.81	low_impact	-0.35	medium_impact	2.63	high_impact	0.64	0.8	74.33	11.54	0.58	P	0.66	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9467	9467	T	G	MI.7186	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	261	87	I	M	atT/atG	5.91	1	0	probably_damaging	0.99	neutral	0.1	neutral	1.98	deleterious	-3.39	deleterious	-2.72	high_impact	4.25	0.61	neutral	0.02	damaging	3.31	22.90	deleterious	0.07	0.35	0.49	neutral	0.77	disease	0.74	disease	0.74	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.75	deleterious	-2.81	low_impact	-0.35	medium_impact	2.63	high_impact	0.64	0.8	74.33	11.54	0.57	P	0.66	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9468	9468	A	G	MI.7187	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	262	88	T	A	Acc/Gcc	-2.19	0	0.01	benign	0.03	neutral	0.48	neutral	2.33	neutral	0.14	neutral	-1.35	neutral_impact	0.37	0.75	neutral	0.72	neutral	0.33	5.99	deleterious	0.28	0.45	0.14	neutral	0.48	neutral	0.41	neutral	0.44	neutral	1	0.49	neutral	0.73	deleterious	-6	neutral	0.10	neutral	0.6	medium_impact	0.17	medium_impact	-0.85	medium_impact	0.39	0.8	16.09	18.26	0.33	N	0.16	polymorphism	1	0.03	rs879015841	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9468	9468	A	T	MI.7188	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	262	88	T	S	Acc/Tcc	-2.19	0	0.01	benign	0.09	neutral	0.26	neutral	2.28	neutral	-0.81	neutral	-1.89	neutral_impact	0.62	0.69	neutral	0.69	neutral	1.37	12.66	neutral	0.33	0.5	0.13	neutral	0.61	disease	0.55	disease	0.62	disease	2	0.71	neutral	0.59	deleterious	-6	neutral	0.14	neutral	0.11	medium_impact	-0.07	medium_impact	-0.63	medium_impact	0.73	0.85	16.09	18.26	0.37	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9468	9468	A	C	MI.7189	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	262	88	T	P	Acc/Ccc	-2.19	0	0.01	benign	0.37	neutral	0.1	neutral	2.25	neutral	-2.31	deleterious	-3.07	medium_impact	2.92	0.59	damaging	0.34	neutral	1.76	14.77	neutral	0.05	0.35	0.39	neutral	0.9	disease	0.71	disease	0.8	disease	6	0.88	neutral	0.37	neutral	-3	neutral	0.43	neutral	-0.64	medium_impact	-0.35	medium_impact	1.43	medium_impact	0.47	0.8	16.09	18.26	0.33	N	0.74	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8866	8866	A	C	MI.719	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	340	114	I	L	Att/Ctt	-3.8	0	0	benign	0	neutral	1	neutral	4.44	neutral	0.26	neutral	-0.57	neutral_impact	-0.05	0.89	neutral	0.94	neutral	-0.36	0.47	neutral	0.29	0.65	0.51	disease	0.2	neutral	0.27	neutral	0.29	neutral	4	0	neutral	1	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	1.98	high_impact	-1.14	low_impact	0.65	0.9	18.14	12.08	0.33	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9469	9469	C	A	MI.7190	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	263	88	T	N	aCc/aAc	0.59	0	0	benign	0.37	neutral	0.06	neutral	2.26	neutral	-1.87	deleterious	-2.98	medium_impact	2.92	0.66	neutral	0.51	neutral	1.92	15.69	deleterious	0.26	0.45	0.31	neutral	0.81	disease	0.6	disease	0.76	disease	5	0.93	neutral	0.35	neutral	-3	neutral	0.34	neutral	-0.64	medium_impact	-0.49	medium_impact	1.43	medium_impact	0.56	0.8	16.09	18.26	0.39	N	0.53	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9469	9469	C	T	MI.7191	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	263	88	T	I	aCc/aTc	0.59	0	0	benign	0	neutral	0.72	neutral	2.49	neutral	1.59	neutral	-0.16	neutral_impact	-0.33	0.74	neutral	0.93	neutral	0.29	5.63	deleterious	0.13	0.4	0.12	neutral	0.58	disease	0.37	neutral	0.43	neutral	1	0.28	neutral	0.86	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.43	medium_impact	-1.48	low_impact	0.72	0.85	16.09	18.26	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9469	9469	C	G	MI.7192	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	263	88	T	S	aCc/aGc	0.59	0	0	benign	0.09	neutral	0.26	neutral	2.28	neutral	-0.81	neutral	-1.89	neutral_impact	0.62	0.69	neutral	0.69	neutral	1.58	13.76	neutral	0.33	0.5	0.13	neutral	0.61	disease	0.55	disease	0.62	disease	2	0.71	neutral	0.59	deleterious	-6	neutral	0.14	neutral	0.11	medium_impact	-0.07	medium_impact	-0.63	medium_impact	0.73	0.85	16.09	18.26	0.39	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9471	9471	T	C	MI.7193	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	265	89	S	P	Tca/Cca	-5.19	0	0	probably_damaging	1	neutral	0.06	neutral	1.49	deleterious	-5.22	deleterious	-4.56	high_impact	4.18	0.52	damaging	0.05	damaging	3.91	23.50	deleterious	0.03	0.35	0.65	disease	0.87	disease	0.82	disease	0.82	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.49	medium_impact	2.56	high_impact	0.33	0.8	74.71	11.51	0.43	N	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9471	9471	T	A	MI.7194	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	265	89	S	T	Tca/Aca	-5.19	0	0	probably_damaging	0.96	neutral	0.15	neutral	1.54	deleterious	-3.87	deleterious	-2.72	medium_impact	3.23	0.53	damaging	0.03	damaging	3.73	23.30	deleterious	0.18	0.45	0.21	neutral	0.73	disease	0.74	disease	0.69	disease	4	0.98	neutral	0.1	neutral	1	deleterious	0.72	deleterious	-2.21	low_impact	-0.24	medium_impact	1.71	medium_impact	0.71	0.85	74.71	11.51	0.31	N	0.63	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9471	9471	T	G	MI.7195	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	265	89	S	A	Tca/Gca	-5.19	0	0	probably_damaging	0.98	neutral	0.16	neutral	1.59	deleterious	-3.09	deleterious	-2.72	medium_impact	3.01	0.57	damaging	0.09	damaging	3.65	23.20	deleterious	0.14	0.4	0.22	neutral	0.72	disease	0.71	disease	0.71	disease	4	0.99	deleterious	0.09	neutral	1	deleterious	0.67	deleterious	-2.51	low_impact	-0.22	medium_impact	1.52	medium_impact	0.50	0.8	74.71	11.51	0.26	N	0.40	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9472	9472	C	G	MI.7196	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	266	89	S	W	tCa/tGa	7.53	1	0	probably_damaging	1	neutral	0.05	neutral	1.47	deleterious	-7.87	deleterious	-6.37	high_impact	4.38	0.62	neutral	0.02	damaging	4.27	24.00	deleterious	0.04	0.35	0.92	disease	0.93	disease	0.77	disease	0.86	disease	7	1	deleterious	0.03	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.54	medium_impact	2.74	high_impact	0.15	0.8	74.71	11.51	0.52	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9472	9472	C	T	MI.7197	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	266	89	S	L	tCa/tTa	7.53	1	0	probably_damaging	1	neutral	0.54	neutral	1.5	deleterious	-4.81	deleterious	-5.45	high_impact	4.38	0.57	damaging	0.03	damaging	4.58	24.40	deleterious	0.02	0.35	0.63	disease	0.91	disease	0.71	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	0.23	medium_impact	2.74	high_impact	0.46	0.8	74.71	11.51	0.53	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9474	9474	G	A	MI.7198	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	268	90	E	K	Gaa/Aaa	-4.04	0	0	probably_damaging	0.99	neutral	0.35	neutral	1.56	deleterious	-4.69	deleterious	-3.63	high_impact	4.21	0.52	damaging	0.04	damaging	4.39	24.10	deleterious	0.05	0.35	0.55	disease	0.92	disease	0.83	disease	0.83	disease	7	0.99	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-2.81	low_impact	0.04	medium_impact	2.59	high_impact	0.76	0.85	73.95	11.74	0.45	N	0.97	polymorphism	1	0.50	.	.	.	.	.	.	COSM1138432	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9474	9474	G	C	MI.7199	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	268	90	E	Q	Gaa/Caa	-4.04	0	0	probably_damaging	0.99	neutral	0.33	neutral	1.55	deleterious	-5.03	deleterious	-2.72	high_impact	4.76	0.56	damaging	0.05	damaging	3.30	22.90	deleterious	0.1	0.4	0.59	disease	0.79	disease	0.78	disease	0.76	disease	5	0.99	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-2.81	low_impact	0.02	medium_impact	3.08	high_impact	0.62	0.8	73.95	11.74	0.68	P	0.87	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8557	8557	G	A	MI.72	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	31	11	A	T	Gcc/Acc	-0.8	0	0.02	benign	0.01	neutral	0.33	neutral	4.68	neutral	-0.25	neutral	1.16	neutral_impact	0	0.99	neutral	0.95	neutral	0.67	8.62	deleterious	0.49	0.65	0.32	neutral	0.32	neutral	0.19	neutral	0.46	neutral	1	0.67	neutral	0.66	deleterious	-6	neutral	0.11	neutral	1.14	medium_impact	0.12	medium_impact	-1.1	low_impact	0.63	0.9	23.45	19.76	0.54	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8866	8866	A	T	MI.720	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	340	114	I	F	Att/Ttt	-3.8	0	0	benign	0.03	neutral	0.29	neutral	4.24	neutral	-1.12	neutral	-2.4	low_impact	1.8	0.91	neutral	0.9	neutral	1.73	14.58	neutral	0.37	0.65	0.58	disease	0.79	disease	0.54	disease	0.55	disease	1	0.69	neutral	0.63	deleterious	-6	neutral	0.28	neutral	0.68	medium_impact	0.07	medium_impact	0.45	medium_impact	0.77	0.9	18.14	12.08	0.3	N	0.62	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9475	9475	A	T	MI.7200	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	269	90	E	V	gAa/gTa	7.53	1	0	probably_damaging	1	neutral	0.53	neutral	1.53	deleterious	-5.55	deleterious	-6.35	high_impact	4.76	0.47	damaging	0.05	damaging	3.98	23.60	deleterious	0.03	0.35	0.76	disease	0.93	disease	0.78	disease	0.82	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	0.22	medium_impact	3.08	high_impact	0.23	0.8	73.95	11.74	0.69	P	0.83	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9475	9475	A	G	MI.7201	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	269	90	E	G	gAa/gGa	7.53	1	0	probably_damaging	1	neutral	0.35	neutral	1.52	deleterious	-6.54	deleterious	-6.35	high_impact	4.76	0.52	damaging	0.06	damaging	4.11	23.70	deleterious	0.04	0.35	0.48	neutral	0.86	disease	0.77	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.04	medium_impact	3.08	high_impact	0.15	0.8	73.95	11.74	0.68	P	0.62	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9475	9475	A	C	MI.7202	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	269	90	E	A	gAa/gCa	7.53	1	0	probably_damaging	1	neutral	0.55	neutral	1.56	deleterious	-4.69	deleterious	-5.43	high_impact	4.76	0.53	damaging	0.08	damaging	3.50	23.10	deleterious	0.04	0.35	0.55	disease	0.82	disease	0.76	disease	0.76	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	0.24	medium_impact	3.08	high_impact	0.31	0.8	73.95	11.74	0.72	P	0.66	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9476	9476	A	T	MI.7203	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	270	90	E	D	gaA/gaT	8.69	1	0	probably_damaging	0.98	neutral	0.25	neutral	1.76	neutral	-2.47	deleterious	-2.72	medium_impact	3.13	0.53	damaging	0.04	damaging	3.77	23.40	deleterious	0.14	0.4	0.41	neutral	0.8	disease	0.77	disease	0.74	disease	5	0.98	deleterious	0.14	neutral	1	deleterious	0.76	deleterious	-2.51	low_impact	-0.08	medium_impact	1.62	medium_impact	0.56	0.8	73.95	11.74	0.61	P	0.93	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9476	9476	A	C	MI.7204	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	270	90	E	D	gaA/gaC	8.69	1	0	probably_damaging	0.98	neutral	0.25	neutral	1.76	neutral	-2.47	deleterious	-2.72	medium_impact	3.13	0.53	damaging	0.04	damaging	3.62	23.20	deleterious	0.14	0.4	0.41	neutral	0.8	disease	0.77	disease	0.74	disease	5	0.98	deleterious	0.14	neutral	1	deleterious	0.76	deleterious	-2.51	low_impact	-0.08	medium_impact	1.62	medium_impact	0.56	0.8	73.95	11.74	0.61	P	0.93	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9477	9477	G	T	MI.7205	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	271	91	V	F	Gtt/Ttt	0.36	0.93	0.13	benign	0.2	neutral	0.49	neutral	1.98	deleterious	-3.38	deleterious	-4.07	medium_impact	3.32	0.62	neutral	0.49	neutral	2.18	17.35	deleterious	0.05	0.35	0.31	neutral	0.93	disease	0.61	disease	0.69	disease	4	0.41	neutral	0.65	deleterious	-3	neutral	0.46	deleterious	-0.28	medium_impact	0.18	medium_impact	1.79	medium_impact	0.28	0.8	26.05	16.97	0.4	N	0.98	polymorphism	1	0.13	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9477	9477	G	C	MI.7206	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	271	91	V	L	Gtt/Ctt	0.36	0.93	0.13	benign	0	neutral	0.41	neutral	2.09	neutral	-1.09	neutral	-2.25	medium_impact	2.22	0.66	neutral	0.47	neutral	1.50	13.32	neutral	0.25	0.45	0.18	neutral	0.79	disease	0.47	neutral	0.52	disease	0	0.59	neutral	0.71	deleterious	-3	neutral	0.16	neutral	2.05	high_impact	0.1	medium_impact	0.81	medium_impact	0.61	0.8	26.05	16.97	0.41	N	0.72	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9477	9477	G	A	MI.7207	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	271	91	V	I	Gtt/Att	0.36	0.93	0.13	benign	0	neutral	0.47	neutral	2.14	neutral	-1.43	neutral	-0.54	low_impact	1.45	0.93	neutral	0.88	neutral	0.45	7.07	deleterious	0.37	0.5	0.13	neutral	0.42	neutral	0.34	neutral	0.38	neutral	2	0.53	neutral	0.74	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	0.16	medium_impact	0.12	medium_impact	0.78	0.85	26.05	16.97	0.34	N	0.32	polymorphism	1	0.02	rs2853825	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9478	9478	T	A	MI.7208	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	272	91	V	D	gTt/gAt	3.6	1	0	benign	0.25	deleterious	0.02	neutral	1.91	deleterious	-5.56	deleterious	-6.04	high_impact	4.36	0.57	damaging	0.42	neutral	4.27	24.00	deleterious	0.03	0.35	0.62	disease	0.9	disease	0.71	disease	0.78	disease	6	0.98	neutral	0.39	neutral	2	deleterious	0.57	deleterious	-0.41	medium_impact	-0.77	medium_impact	2.73	high_impact	0.14	0.8	26.05	16.97	0.43	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9478	9478	T	G	MI.7209	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	272	91	V	G	gTt/gGt	3.6	1	0	benign	0.12	deleterious	0.01	neutral	1.92	deleterious	-4.03	deleterious	-6.17	medium_impact	2.57	0.58	damaging	0.62	neutral	2.10	16.84	deleterious	0.05	0.35	0.39	neutral	0.85	disease	0.62	disease	0.71	disease	4	0.99	deleterious	0.45	neutral	1	deleterious	0.33	neutral	-0.03	medium_impact	-0.95	medium_impact	1.12	medium_impact	0.23	0.8	26.05	16.97	0.41	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8867	8867	T	C	MI.721	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	341	114	I	T	aTt/aCt	-1.03	0	0	benign	0	neutral	0.07	neutral	4.14	neutral	-2.63	deleterious	-2.82	medium_impact	2.1	0.91	neutral	0.63	neutral	1.42	12.89	neutral	0.38	0.65	0.55	disease	0.71	disease	0.56	disease	0.62	disease	2	0.93	neutral	0.54	deleterious	-3	neutral	0.21	neutral	2.09	high_impact	-0.34	medium_impact	0.7	medium_impact	0.50	0.9	18.14	12.08	0.35	N	0.57	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9478	9478	T	C	MI.7210	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	272	91	V	A	gTt/gCt	3.6	1	0	benign	0	neutral	0.36	neutral	2.01	neutral	-2.06	deleterious	-3.41	medium_impact	2.28	0.76	neutral	0.68	neutral	1.56	13.61	neutral	0.13	0.4	0.16	neutral	0.62	disease	0.51	disease	0.42	neutral	2	0.64	neutral	0.68	deleterious	-3	neutral	0.14	neutral	2.05	high_impact	0.05	medium_impact	0.86	medium_impact	0.17	0.8	26.05	16.97	0.59	P	0.37	disease_causing_automatic	0	0.11	rs587776437	Pathogenic	Leigh_syndrome	165634	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	CPD	1.34	T9478C	Leigh Disease	-	+	Reported	1	P	P	P	neutral
chrM	9480	9480	T	C	MI.7211	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	274	92	F	L	Ttt/Ctt	-16.07	0	0	probably_damaging	0.97	neutral	0.32	neutral	2.55	neutral	1.12	neutral	-0.35	low_impact	1.1	0.78	neutral	0.96	neutral	0.46	7.12	deleterious	0.22	0.45	0.15	neutral	0.46	neutral	0.3	neutral	0.45	neutral	1	0.97	neutral	0.18	neutral	-2	neutral	0.63	deleterious	-2.34	low_impact	0.01	medium_impact	-0.2	medium_impact	0.57	0.8	10.34	40.23	0.34	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9480	9480	T	G	MI.7212	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	274	92	F	V	Ttt/Gtt	-16.07	0	0	probably_damaging	0.98	neutral	0.3	neutral	2.34	neutral	0.2	neutral	-1.89	medium_impact	2.06	0.63	neutral	0.52	neutral	3.49	23.10	deleterious	0.15	0.4	0.1	neutral	0.82	disease	0.47	neutral	0.62	disease	2	0.98	deleterious	0.16	neutral	1	deleterious	0.65	deleterious	-2.51	low_impact	-0.02	medium_impact	0.66	medium_impact	0.17	0.8	10.34	40.23	0.39	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9480	9480	T	A	MI.7213	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	274	92	F	I	Ttt/Att	-16.07	0	0	probably_damaging	0.98	neutral	0.16	neutral	2.34	neutral	-0.06	neutral	-1.16	medium_impact	2.24	0.66	neutral	0.51	neutral	2.60	20.20	deleterious	0.15	0.4	0.15	neutral	0.84	disease	0.36	neutral	0.73	disease	5	0.99	deleterious	0.09	neutral	1	deleterious	0.68	deleterious	-2.51	low_impact	-0.22	medium_impact	0.83	medium_impact	0.30	0.8	10.34	40.23	0.39	N	0.78	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9481	9481	T	A	MI.7214	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	275	92	F	Y	tTt/tAt	1.52	0.91	0	probably_damaging	0.97	neutral	0.2	neutral	2.21	neutral	-2	neutral	-1.49	high_impact	3.65	0.64	neutral	0.47	neutral	3.88	23.50	deleterious	0.21	0.45	0.34	neutral	0.76	disease	0.57	disease	0.7	disease	4	0.98	deleterious	0.12	neutral	2	deleterious	0.70	deleterious	-2.34	low_impact	-0.15	medium_impact	2.09	high_impact	0.41	0.8	10.34	40.23	0.4	N	0.73	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9481	9481	T	G	MI.7215	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	275	92	F	C	tTt/tGt	1.52	0.91	0	probably_damaging	1	neutral	0.07	neutral	2.22	neutral	-2.67	neutral	-1.69	neutral_impact	0.55	0.7	neutral	0.79	neutral	2.61	20.30	deleterious	0.1	0.4	0.46	neutral	0.77	disease	0.36	neutral	0.52	disease	0	1	deleterious	0.04	neutral	-2	neutral	0.71	deleterious	-3.78	low_impact	-0.45	medium_impact	-0.69	medium_impact	0.13	0.8	10.34	40.23	0.34	N	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9481	9481	T	C	MI.7216	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	275	92	F	S	tTt/tCt	1.52	0.91	0	probably_damaging	0.99	neutral	0.17	neutral	2.23	neutral	-1.34	deleterious	-3.47	medium_impact	2.5	0.68	neutral	0.48	neutral	3.92	23.50	deleterious	0.06	0.35	0.28	neutral	0.76	disease	0.56	disease	0.7	disease	4	0.99	deleterious	0.09	neutral	1	deleterious	0.70	deleterious	-2.81	low_impact	-0.2	medium_impact	1.06	medium_impact	0.26	0.8	10.34	40.23	0.34	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9482	9482	T	G	MI.7217	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	276	92	F	L	ttT/ttG	4.52	0.97	0	probably_damaging	0.97	neutral	0.32	neutral	2.55	neutral	1.12	neutral	-0.35	low_impact	1.1	0.78	neutral	0.96	neutral	0.65	8.53	deleterious	0.22	0.45	0.15	neutral	0.46	neutral	0.3	neutral	0.45	neutral	1	0.97	neutral	0.18	neutral	-2	neutral	0.63	deleterious	-2.34	low_impact	0.01	medium_impact	-0.2	medium_impact	0.57	0.8	10.34	40.23	0.46	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9482	9482	T	A	MI.7218	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	276	92	F	L	ttT/ttA	4.52	0.97	0	probably_damaging	0.97	neutral	0.32	neutral	2.55	neutral	1.12	neutral	-0.35	low_impact	1.1	0.78	neutral	0.96	neutral	0.84	9.69	deleterious	0.22	0.45	0.15	neutral	0.46	neutral	0.3	neutral	0.45	neutral	1	0.97	neutral	0.18	neutral	-2	neutral	0.63	deleterious	-2.34	low_impact	0.01	medium_impact	-0.2	medium_impact	0.57	0.8	10.34	40.23	0.47	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9483	9483	T	G	MI.7219	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	277	93	F	V	Ttc/Gtc	-1.03	0.01	0	benign	0.23	neutral	0.11	neutral	2.16	neutral	-1.44	deleterious	-6.21	medium_impact	3.21	0.66	neutral	0.02	damaging	3.66	23.20	deleterious	0.12	0.4	0.19	neutral	0.87	disease	0.61	disease	0.67	disease	3	0.87	neutral	0.44	neutral	-3	neutral	0.33	neutral	-0.36	medium_impact	-0.33	medium_impact	1.69	medium_impact	0.28	0.8	73.18	11.45	0.32	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8867	8867	T	G	MI.722	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	341	114	I	S	aTt/aGt	-1.03	0	0	benign	0.01	neutral	0.14	neutral	4.13	deleterious	-3.03	deleterious	-3.41	medium_impact	2.66	0.84	neutral	0.49	neutral	2.25	17.82	deleterious	0.24	0.65	0.74	disease	0.85	disease	0.59	disease	0.65	disease	3	0.86	neutral	0.57	deleterious	-3	neutral	0.28	neutral	1.14	medium_impact	-0.15	medium_impact	1.18	medium_impact	0.51	0.9	18.14	12.08	0.34	N	0.54	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9483	9483	T	C	MI.7220	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	277	93	F	L	Ttc/Ctc	-1.03	0.01	0	benign	0	neutral	0.3	neutral	2.32	neutral	-0.54	deleterious	-5.32	medium_impact	2.71	0.47	damaging	0.06	damaging	1.99	16.12	deleterious	0.18	0.45	0.1	neutral	0.77	disease	0.42	neutral	0.5	neutral	0	0.7	neutral	0.65	deleterious	-3	neutral	0.14	neutral	2.05	high_impact	-0.02	medium_impact	1.25	medium_impact	0.42	0.8	73.18	11.45	0.34	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9483	9483	T	A	MI.7221	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	277	93	F	I	Ttc/Atc	-1.03	0.01	0	benign	0.07	neutral	0.25	neutral	2.19	neutral	-1.58	deleterious	-5.33	medium_impact	2.67	0.7	neutral	0.02	damaging	2.55	19.81	deleterious	0.16	0.45	0.16	neutral	0.86	disease	0.6	disease	0.53	disease	1	0.72	neutral	0.59	deleterious	-3	neutral	0.33	neutral	0.22	medium_impact	-0.08	medium_impact	1.21	medium_impact	0.44	0.8	73.18	11.45	0.28	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9484	9484	T	C	MI.7222	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	278	93	F	S	tTc/tCc	7.53	1	0	possibly_damaging	0.69	neutral	0.08	neutral	2.04	deleterious	-3.62	deleterious	-6.89	high_impact	4.11	0.66	neutral	0.03	damaging	4.05	23.70	deleterious	0.05	0.35	0.32	neutral	0.84	disease	0.61	disease	0.7	disease	4	0.93	neutral	0.2	neutral	1	deleterious	0.64	deleterious	-1.21	low_impact	-0.41	medium_impact	2.5	high_impact	0.38	0.8	73.18	11.45	0.52	P	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9484	9484	T	A	MI.7223	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	278	93	F	Y	tTc/tAc	7.53	1	0	benign	0.26	deleterious	0.02	neutral	2.05	deleterious	-4.23	deleterious	-2.67	high_impact	4.65	0.7	neutral	0.03	damaging	3.98	23.60	deleterious	0.17	0.45	0.41	neutral	0.83	disease	0.62	disease	0.69	disease	4	0.98	neutral	0.38	neutral	2	deleterious	0.51	deleterious	-0.43	medium_impact	-0.77	medium_impact	2.99	high_impact	0.53	0.8	73.18	11.45	0.52	P	0.80	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9484	9484	T	G	MI.7224	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	278	93	F	C	tTc/tGc	7.53	1	0	probably_damaging	0.91	deleterious	0.02	neutral	2.02	deleterious	-4.99	deleterious	-6.88	high_impact	4.65	0.71	neutral	0.02	damaging	3.98	23.60	deleterious	0.07	0.35	0.54	disease	0.9	disease	0.64	disease	0.72	disease	4	0.99	deleterious	0.06	neutral	6	deleterious	0.74	deleterious	-1.85	low_impact	-0.77	medium_impact	2.99	high_impact	0.26	0.8	73.18	11.45	0.47	N	0.98	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9485	9485	C	A	MI.7225	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	279	93	F	L	ttC/ttA	7.53	1	0	benign	0	neutral	0.3	neutral	2.32	neutral	-0.54	deleterious	-5.32	medium_impact	2.71	0.47	damaging	0.06	damaging	2.66	20.60	deleterious	0.18	0.45	0.1	neutral	0.77	disease	0.42	neutral	0.5	neutral	0	0.7	neutral	0.65	deleterious	-3	neutral	0.14	neutral	2.05	high_impact	-0.02	medium_impact	1.25	medium_impact	0.42	0.8	73.18	11.45	0.52	P	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9485	9485	C	G	MI.7226	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	279	93	F	L	ttC/ttG	7.53	1	0	benign	0	neutral	0.3	neutral	2.32	neutral	-0.54	deleterious	-5.32	medium_impact	2.71	0.47	damaging	0.06	damaging	2.37	18.62	deleterious	0.18	0.45	0.1	neutral	0.77	disease	0.42	neutral	0.5	neutral	0	0.7	neutral	0.65	deleterious	-3	neutral	0.14	neutral	2.05	high_impact	-0.02	medium_impact	1.25	medium_impact	0.42	0.8	73.18	11.45	0.51	P	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9486	9486	T	G	MI.7227	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	280	94	F	V	Ttc/Gtc	-1.49	0	0	probably_damaging	1	deleterious	0.04	neutral	0.43	deleterious	-7.69	deleterious	-6.18	high_impact	4.79	0.66	neutral	0.02	damaging	3.95	23.60	deleterious	0.06	0.35	0.56	disease	0.86	disease	0.71	disease	0.76	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.77	deleterious	-3.78	low_impact	-0.6	medium_impact	3.11	high_impact	0.20	0.8	73.95	11.75	0.55	P	0.97	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9486	9486	T	C	MI.7228	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	280	94	F	L	Ttc/Ctc	-1.49	0	0	probably_damaging	0.98	neutral	0.14	neutral	0.49	deleterious	-5.79	deleterious	-5.34	high_impact	3.98	0.51	damaging	0.03	damaging	3.93	23.50	deleterious	0.05	0.35	0.27	neutral	0.79	disease	0.63	disease	0.63	disease	3	0.99	deleterious	0.08	neutral	2	deleterious	0.72	deleterious	-2.51	low_impact	-0.26	medium_impact	2.38	high_impact	0.35	0.8	73.95	11.75	0.32	N	0.92	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9486	9486	T	A	MI.7229	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	280	94	F	I	Ttc/Atc	-1.49	0	0	probably_damaging	0.99	neutral	0.14	neutral	0.43	deleterious	-7.41	deleterious	-5.32	high_impact	4.79	0.69	neutral	0.02	damaging	4.26	23.90	deleterious	0.06	0.35	0.53	disease	0.87	disease	0.69	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.79	deleterious	-2.81	low_impact	-0.26	medium_impact	3.11	high_impact	0.26	0.8	73.95	11.75	0.57	P	0.96	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8867	8867	T	A	MI.723	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	341	114	I	N	aTt/aAt	-1.03	0	0	benign	0.02	deleterious	0	neutral	4.11	deleterious	-4.24	deleterious	-4.75	high_impact	3.7	0.78	neutral	0.43	neutral	2.43	19.04	deleterious	0.22	0.65	0.66	disease	0.87	disease	0.62	disease	0.74	disease	5	1	deleterious	0.49	deleterious	2	deleterious	0.28	neutral	0.85	medium_impact	-1.4	low_impact	2.07	high_impact	0.61	0.9	18.14	12.08	0.37	N	0.82	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9487	9487	T	A	MI.7230	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	281	94	F	Y	tTc/tAc	5.91	1	0	probably_damaging	0.98	neutral	0.06	neutral	0.48	deleterious	-5.92	deleterious	-2.67	high_impact	4.44	0.7	neutral	0.03	damaging	4.24	23.90	deleterious	0.09	0.35	0.44	neutral	0.81	disease	0.66	disease	0.69	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.76	deleterious	-2.51	low_impact	-0.49	medium_impact	2.8	high_impact	0.44	0.8	73.95	11.75	0.56	P	0.80	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9487	9487	T	G	MI.7231	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	281	94	F	C	tTc/tGc	5.91	1	0	probably_damaging	1	deleterious	0	neutral	0.41	deleterious	-10.25	deleterious	-6.99	high_impact	4.79	0.71	neutral	0.02	damaging	4.06	23.70	deleterious	0.04	0.35	0.89	disease	0.88	disease	0.72	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.78	low_impact	-1.52	low_impact	3.11	high_impact	0.15	0.8	73.95	11.75	0.58	P	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9487	9487	T	C	MI.7232	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	281	94	F	S	tTc/tCc	5.91	1	0	probably_damaging	1	neutral	0.19	neutral	0.41	deleterious	-9.65	deleterious	-6.9	high_impact	4.44	0.69	neutral	0.03	damaging	4.16	23.80	deleterious	0.03	0.35	0.78	disease	0.82	disease	0.66	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.17	medium_impact	2.8	high_impact	0.17	0.8	73.95	11.75	0.5	N	0.96	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9488	9488	C	G	MI.7233	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	282	94	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.98	neutral	0.14	neutral	0.49	deleterious	-5.79	deleterious	-5.34	high_impact	3.98	0.51	damaging	0.03	damaging	4.29	24.00	deleterious	0.05	0.35	0.27	neutral	0.79	disease	0.63	disease	0.63	disease	3	0.99	deleterious	0.08	neutral	2	deleterious	0.72	deleterious	-2.51	low_impact	-0.26	medium_impact	2.38	high_impact	0.35	0.8	73.95	11.75	0.51	N	0.92	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9488	9488	C	A	MI.7234	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	282	94	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.98	neutral	0.14	neutral	0.49	deleterious	-5.79	deleterious	-5.34	high_impact	3.98	0.51	damaging	0.03	damaging	4.62	24.50	deleterious	0.05	0.35	0.27	neutral	0.79	disease	0.63	disease	0.63	disease	3	0.99	deleterious	0.08	neutral	2	deleterious	0.72	deleterious	-2.51	low_impact	-0.26	medium_impact	2.38	high_impact	0.35	0.8	73.95	11.75	0.52	N	0.92	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9489	9489	G	T	MI.7235	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	283	95	A	S	Gca/Tca	-2.65	0	0	benign	0.08	neutral	0.19	neutral	2.23	neutral	-1.37	neutral	-0.57	low_impact	1.45	0.74	neutral	0.89	neutral	0.79	9.42	deleterious	0.16	0.45	0.18	neutral	0.38	neutral	0.42	neutral	0.45	neutral	1	0.79	neutral	0.56	deleterious	-6	neutral	0.15	neutral	0.16	medium_impact	-0.17	medium_impact	0.12	medium_impact	0.34	0.8	18.39	37.46	0.49	N	0.05	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9489	9489	G	C	MI.7236	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	283	95	A	P	Gca/Cca	-2.65	0	0	benign	0.3	deleterious	0.01	neutral	2.19	neutral	-2.92	neutral	-2.06	medium_impact	2.64	0.55	damaging	0.32	neutral	3.52	23.10	deleterious	0.04	0.35	0.48	neutral	0.79	disease	0.59	disease	0.76	disease	5	0.99	deleterious	0.36	neutral	1	deleterious	0.57	deleterious	-0.51	medium_impact	-0.95	medium_impact	1.18	medium_impact	0.43	0.8	18.39	37.46	0.29	N	0.76	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9489	9489	G	A	MI.7237	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	283	95	A	T	Gca/Aca	-2.65	0	0	benign	0	neutral	0.05	neutral	2.25	neutral	-0.9	neutral	-0.13	medium_impact	2.3	0.78	neutral	0.97	neutral	1.06	11.00	neutral	0.11	0.4	0.22	neutral	0.35	neutral	0.38	neutral	0.44	neutral	1	0.95	neutral	0.53	deleterious	-3	neutral	0.11	neutral	2.05	high_impact	-0.54	medium_impact	0.88	medium_impact	0.60	0.8	18.39	37.46	0.48	N	0.03	polymorphism	1	0.02	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9490	9490	C	T	MI.7238	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	284	95	A	V	gCa/gTa	-1.26	0	0	benign	0	neutral	0.09	neutral	2.35	neutral	0.29	neutral	1.07	neutral_impact	0.73	0.77	neutral	0.78	neutral	1.20	11.72	neutral	0.09	0.35	0.15	neutral	0.28	neutral	0.24	neutral	0.43	neutral	1	0.91	neutral	0.55	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	-0.38	medium_impact	-0.53	medium_impact	0.55	0.8	18.39	37.46	0.41	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9490	9490	C	G	MI.7239	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	284	95	A	G	gCa/gGa	-1.26	0	0	benign	0.16	neutral	0.12	neutral	2.2	neutral	-2.41	neutral	-2.11	low_impact	1.09	0.66	neutral	0.66	neutral	2.12	16.96	deleterious	0.14	0.4	0.23	neutral	0.47	neutral	0.41	neutral	0.49	neutral	0	0.86	neutral	0.48	deleterious	-6	neutral	0.25	neutral	-0.17	medium_impact	-0.3	medium_impact	-0.21	medium_impact	0.51	0.8	18.39	37.46	0.47	N	0.22	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8868	8868	T	A	MI.724	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	342	114	I	M	atT/atA	3.6	0.36	0	benign	0.07	neutral	0.14	neutral	4.14	neutral	-2.76	neutral	-1.41	medium_impact	2.02	0.91	neutral	0.67	neutral	1.77	14.79	neutral	0.37	0.65	0.8	disease	0.57	disease	0.41	neutral	0.52	disease	0	0.85	neutral	0.54	deleterious	-3	neutral	0.30	neutral	0.31	medium_impact	-0.15	medium_impact	0.63	medium_impact	0.76	0.9	18.14	12.08	0.37	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9490	9490	C	A	MI.7240	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	284	95	A	E	gCa/gAa	-1.26	0	0	benign	0.24	deleterious	0.01	neutral	2.21	neutral	-2.05	neutral	-1.71	medium_impact	2.99	0.63	neutral	0.58	neutral	2.80	21.40	deleterious	0.05	0.35	0.29	neutral	0.67	disease	0.59	disease	0.71	disease	4	0.99	deleterious	0.39	neutral	1	deleterious	0.32	neutral	-0.38	medium_impact	-0.95	medium_impact	1.5	medium_impact	0.41	0.8	18.39	37.46	0.42	N	0.70	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9492	9492	G	T	MI.7241	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	286	96	G	W	Gga/Tga	-10.75	0	0	probably_damaging	1	neutral	0.13	neutral	2.16	deleterious	-4.94	deleterious	-4.42	high_impact	3.58	0.58	damaging	0.15	damaging	4.33	24.00	deleterious	0.06	0.35	0.77	disease	0.85	disease	0.61	disease	0.75	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.28	medium_impact	2.03	high_impact	0.12	0.8	73.95	11.69	0.25	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9492	9492	G	C	MI.7242	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	286	96	G	R	Gga/Cga	-10.75	0	0	probably_damaging	1	neutral	0.12	neutral	2.2	neutral	-2	deleterious	-3.23	medium_impact	3.23	0.55	damaging	0.17	damaging	3.89	23.50	deleterious	0.05	0.35	0.31	neutral	0.86	disease	0.61	disease	0.75	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	-0.3	medium_impact	1.71	medium_impact	0.41	0.8	73.95	11.69	0.31	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9493	9493	G	A	MI.7243	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	287	96	G	E	gGa/gAa	9.38	1	0	probably_damaging	1	neutral	0.11	neutral	2.21	neutral	-1.56	deleterious	-2.87	high_impact	3.58	0.56	damaging	0.19	damaging	3.86	23.50	deleterious	0.06	0.35	0.24	neutral	0.79	disease	0.65	disease	0.73	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.72	deleterious	-3.78	low_impact	-0.33	medium_impact	2.03	high_impact	0.25	0.8	73.95	11.69	0.52	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9493	9493	G	T	MI.7244	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	287	96	G	V	gGa/gTa	9.38	1	0	probably_damaging	1	neutral	0.28	neutral	2.22	neutral	-1.35	deleterious	-3.67	medium_impact	2.6	0.62	neutral	0.27	damaging	3.69	23.30	deleterious	0.09	0.35	0.31	neutral	0.75	disease	0.55	disease	0.65	disease	3	1	deleterious	0.14	neutral	1	deleterious	0.71	deleterious	-3.78	low_impact	-0.04	medium_impact	1.15	medium_impact	0.13	0.8	73.95	11.69	0.48	P	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9493	9493	G	C	MI.7245	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	287	96	G	A	gGa/gCa	9.38	1	0	probably_damaging	1	neutral	0.19	neutral	2.45	neutral	0.89	neutral	-0.66	neutral_impact	-0.42	0.68	neutral	0.71	neutral	1.77	14.83	neutral	0.13	0.4	0.13	neutral	0.19	neutral	0.27	neutral	0.34	neutral	3	1	deleterious	0.1	neutral	-2	neutral	0.64	deleterious	-3.78	low_impact	-0.17	medium_impact	-1.56	low_impact	0.38	0.8	73.95	11.69	0.59	P	0.30	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9495	9495	T	C	MI.7246	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	289	97	F	L	Ttt/Ctt	-12.37	0	0.01	probably_damaging	0.98	neutral	0.05	neutral	2.45	neutral	0.75	deleterious	-5.31	low_impact	1.84	0.57	damaging	0.58	neutral	2.16	17.25	deleterious	0.17	0.45	0.15	neutral	0.72	disease	0.53	disease	0.49	neutral	0	1	deleterious	0.04	neutral	-2	neutral	0.66	deleterious	-2.51	low_impact	-0.54	medium_impact	0.47	medium_impact	0.36	0.8	72.8	11.81	0.39	N	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9495	9495	T	G	MI.7247	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	289	97	F	V	Ttt/Gtt	-12.37	0	0.01	probably_damaging	1	deleterious	0.02	neutral	2.29	neutral	-1.42	deleterious	-6.22	medium_impact	3.23	0.53	damaging	0.54	neutral	3.92	23.50	deleterious	0.09	0.4	0.2	neutral	0.83	disease	0.61	disease	0.64	disease	3	1	deleterious	0.01	neutral	5	deleterious	0.69	deleterious	-3.78	low_impact	-0.77	medium_impact	1.71	medium_impact	0.20	0.8	72.8	11.81	0.41	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9495	9495	T	A	MI.7248	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	289	97	F	I	Ttt/Att	-12.37	0	0.01	probably_damaging	0.99	neutral	0.09	neutral	2.4	neutral	-1.28	deleterious	-5.34	medium_impact	2.81	0.6	neutral	0.58	neutral	2.78	21.30	deleterious	0.13	0.4	0.14	neutral	0.79	disease	0.51	disease	0.49	neutral	0	1	deleterious	0.05	neutral	1	deleterious	0.70	deleterious	-2.81	low_impact	-0.38	medium_impact	1.34	medium_impact	0.32	0.8	72.8	11.81	0.41	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9496	9496	T	G	MI.7249	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	290	97	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	2.1	deleterious	-4.27	deleterious	-7.12	high_impact	4.55	0.64	neutral	0.45	neutral	4.08	23.70	deleterious	0.05	0.35	0.6	disease	0.88	disease	0.67	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-3.78	low_impact	-0.95	medium_impact	2.9	high_impact	0.19	0.8	72.8	11.81	0.51	P	0.98	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8868	8868	T	G	MI.725	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	342	114	I	M	atT/atG	3.6	0.36	0	benign	0.07	neutral	0.14	neutral	4.14	neutral	-2.76	neutral	-1.41	medium_impact	2.02	0.91	neutral	0.67	neutral	1.45	13.05	neutral	0.37	0.65	0.8	disease	0.57	disease	0.41	neutral	0.52	disease	0	0.85	neutral	0.54	deleterious	-3	neutral	0.30	neutral	0.31	medium_impact	-0.15	medium_impact	0.63	medium_impact	0.76	0.9	18.14	12.08	0.37	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9496	9496	T	C	MI.7250	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	290	97	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	neutral	0.39	neutral	2.12	neutral	-2.98	deleterious	-7.08	high_impact	3.86	0.7	neutral	0.62	neutral	4.25	23.90	deleterious	0.04	0.35	0.42	neutral	0.81	disease	0.63	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.08	medium_impact	2.28	high_impact	0.28	0.8	72.8	11.81	0.56	P	0.96	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9496	9496	T	A	MI.7251	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	290	97	F	Y	tTt/tAt	7.53	1	0	probably_damaging	0.98	deleterious	0.04	neutral	2.12	neutral	-2.74	deleterious	-2.69	high_impact	4	0.65	neutral	0.42	neutral	4.36	24.10	deleterious	0.15	0.4	0.29	neutral	0.79	disease	0.64	disease	0.67	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.72	deleterious	-2.51	low_impact	-0.6	medium_impact	2.4	high_impact	0.46	0.8	72.8	11.81	0.6	P	0.80	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9497	9497	T	G	MI.7252	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	291	97	F	L	ttT/ttG	7.53	1	0	probably_damaging	0.98	neutral	0.05	neutral	2.45	neutral	0.75	deleterious	-5.31	low_impact	1.84	0.57	damaging	0.58	neutral	2.22	17.64	deleterious	0.17	0.45	0.15	neutral	0.72	disease	0.53	disease	0.49	neutral	0	1	deleterious	0.04	neutral	-2	neutral	0.66	deleterious	-2.51	low_impact	-0.54	medium_impact	0.47	medium_impact	0.36	0.8	72.8	11.81	0.53	P	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9497	9497	T	A	MI.7253	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	291	97	F	L	ttT/ttA	7.53	1	0	probably_damaging	0.98	neutral	0.05	neutral	2.45	neutral	0.75	deleterious	-5.31	low_impact	1.84	0.57	damaging	0.58	neutral	2.41	18.91	deleterious	0.17	0.45	0.15	neutral	0.72	disease	0.53	disease	0.49	neutral	0	1	deleterious	0.04	neutral	-2	neutral	0.66	deleterious	-2.51	low_impact	-0.54	medium_impact	0.47	medium_impact	0.36	0.8	72.8	11.81	0.54	P	0.92	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9498	9498	T	C	MI.7254	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	292	98	F	L	Ttc/Ctc	-4.04	0	0	probably_damaging	0.98	neutral	0.12	neutral	1.95	neutral	-2.04	deleterious	-5.25	medium_impact	2.81	0.54	damaging	0.61	neutral	3.89	23.50	deleterious	0.1	0.4	0.34	neutral	0.76	disease	0.64	disease	0.61	disease	2	0.99	deleterious	0.07	neutral	1	deleterious	0.73	deleterious	-2.51	low_impact	-0.3	medium_impact	1.34	medium_impact	0.34	0.8	73.95	11.7	0.36	N	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9498	9498	T	A	MI.7255	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	292	98	F	I	Ttc/Atc	-4.04	0	0	probably_damaging	0.98	deleterious	0.02	neutral	1.85	neutral	-2.72	deleterious	-5.31	medium_impact	3.5	0.68	neutral	0.62	neutral	4.26	23.90	deleterious	0.1	0.4	0.52	disease	0.85	disease	0.71	disease	0.76	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.78	deleterious	-2.51	low_impact	-0.77	medium_impact	1.95	medium_impact	0.39	0.8	73.95	11.7	0.35	N	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9498	9498	T	G	MI.7256	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	292	98	F	V	Ttc/Gtc	-4.04	0	0	probably_damaging	0.99	neutral	0.06	neutral	1.74	deleterious	-4	deleterious	-6.24	high_impact	4.19	0.58	damaging	0.54	neutral	3.96	23.60	deleterious	0.07	0.35	0.51	disease	0.84	disease	0.71	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	-0.49	medium_impact	2.57	high_impact	0.29	0.8	73.95	11.7	0.4	N	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9499	9499	T	G	MI.7257	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	293	98	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	1.68	deleterious	-7.21	deleterious	-7.22	high_impact	4.74	0.61	neutral	0.46	neutral	4.00	23.60	deleterious	0.05	0.35	0.84	disease	0.86	disease	0.73	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-3.78	low_impact	-0.95	medium_impact	3.07	high_impact	0.23	0.8	73.95	11.7	0.59	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9499	9499	T	C	MI.7258	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	293	98	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	neutral	0.16	neutral	1.68	deleterious	-6.5	deleterious	-7.23	high_impact	4.74	0.71	neutral	0.63	neutral	4.17	23.80	deleterious	0.05	0.35	0.64	disease	0.81	disease	0.7	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.22	medium_impact	3.07	high_impact	0.39	0.8	73.95	11.7	0.65	P	0.96	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9499	9499	T	A	MI.7259	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	293	98	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.98	neutral	0.1	neutral	1.7	deleterious	-5.24	deleterious	-2.72	high_impact	4.74	0.64	neutral	0.42	neutral	4.16	23.80	deleterious	0.1	0.4	0.42	neutral	0.78	disease	0.69	disease	0.68	disease	4	0.99	deleterious	0.06	neutral	2	deleterious	0.75	deleterious	-2.51	low_impact	-0.35	medium_impact	3.07	high_impact	0.43	0.8	73.95	11.7	0.68	P	0.80	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8869	8869	A	G	MI.726	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	343	115	M	V	Ata/Gta	-4.73	0	0.02	benign	0	neutral	0.37	neutral	4.47	neutral	1.07	neutral	0.29	neutral_impact	0.38	0.95	neutral	0.95	neutral	-0.43	0.33	neutral	0.59	0.7	0.42	neutral	0.57	disease	0.42	neutral	0.39	neutral	2	0.63	neutral	0.69	deleterious	-6	neutral	0.17	neutral	2.09	high_impact	0.16	medium_impact	-0.77	medium_impact	0.35	0.9	21.24	12.41	0.28	N	0.02	polymorphism	1	0.01	rs41432347	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9500	9500	C	A	MI.7260	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	294	98	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.98	neutral	0.12	neutral	1.95	neutral	-2.04	deleterious	-5.25	medium_impact	2.81	0.54	damaging	0.61	neutral	4.54	24.30	deleterious	0.1	0.4	0.34	neutral	0.76	disease	0.64	disease	0.61	disease	2	0.99	deleterious	0.07	neutral	1	deleterious	0.73	deleterious	-2.51	low_impact	-0.3	medium_impact	1.34	medium_impact	0.34	0.8	73.95	11.7	0.54	P	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9500	9500	C	G	MI.7261	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	294	98	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.98	neutral	0.12	neutral	1.95	neutral	-2.04	deleterious	-5.25	medium_impact	2.81	0.54	damaging	0.61	neutral	4.30	24.00	deleterious	0.1	0.4	0.34	neutral	0.76	disease	0.64	disease	0.61	disease	2	0.99	deleterious	0.07	neutral	1	deleterious	0.73	deleterious	-2.51	low_impact	-0.3	medium_impact	1.34	medium_impact	0.34	0.8	73.95	11.7	0.54	P	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9501	9501	T	C	MI.7262	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	295	99	W	R	Tga/Cga	0.82	1	0	probably_damaging	1	deleterious	0.02	neutral	2.03	neutral	-2.47	deleterious	-12.55	medium_impact	3.42	0.59	damaging	0.02	damaging	3.53	23.10	deleterious	0.04	0.35	0.44	neutral	0.91	disease	0.79	disease	0.76	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.80	deleterious	-3.78	low_impact	-0.77	medium_impact	1.88	medium_impact	0.13	0.8	74.71	11.56	0.42	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9501	9501	T	G	MI.7263	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	295	99	W	G	Tga/Gga	0.82	1	0	probably_damaging	0.99	deleterious	0.02	neutral	1.99	deleterious	-3.45	deleterious	-11.65	low_impact	1.86	0.62	neutral	0.02	damaging	3.85	23.40	deleterious	0.06	0.35	0.34	neutral	0.86	disease	0.74	disease	0.73	disease	5	1	deleterious	0.02	neutral	2	deleterious	0.74	deleterious	-2.81	low_impact	-0.77	medium_impact	0.48	medium_impact	0.14	0.8	74.71	11.56	0.31	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9502	9502	G	T	MI.7264	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	296	99	W	L	tGa/tTa	7.53	1	0	probably_damaging	0.99	neutral	0.16	neutral	2.08	neutral	-1.76	deleterious	-11.52	high_impact	3.55	0.63	neutral	0.03	damaging	4.23	23.90	deleterious	0.08	0.35	0.2	neutral	0.86	disease	0.7	disease	0.73	disease	5	0.99	deleterious	0.09	neutral	2	deleterious	0.73	deleterious	-2.81	low_impact	-0.22	medium_impact	2	medium_impact	0.09	0.8	74.71	11.56	0.46	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9502	9502	G	C	MI.7265	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	296	99	W	S	tGa/tCa	7.53	1	0	probably_damaging	1	neutral	0.1	neutral	2.03	neutral	-2.5	deleterious	-12.43	medium_impact	3.33	0.66	neutral	0.03	damaging	3.96	23.60	deleterious	0.06	0.35	0.29	neutral	0.9	disease	0.72	disease	0.76	disease	5	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	-0.35	medium_impact	1.8	medium_impact	0.17	0.8	74.71	11.56	0.42	N	0.97	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9503	9503	A	T	MI.7266	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	297	99	W	C	tgA/tgT	9.15	1	0	probably_damaging	1	deleterious	0.01	neutral	2	deleterious	-3.43	deleterious	-11.66	high_impact	3.98	0.67	neutral	0.02	damaging	4.08	23.70	deleterious	0.06	0.35	0.27	neutral	0.91	disease	0.75	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.78	low_impact	-0.95	medium_impact	2.38	high_impact	0.11	0.8	74.71	11.56	0.45	N	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9503	9503	A	C	MI.7267	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	297	99	W	C	tgA/tgC	9.15	1	0	probably_damaging	1	deleterious	0.01	neutral	2	deleterious	-3.43	deleterious	-11.66	high_impact	3.98	0.67	neutral	0.02	damaging	3.98	23.60	deleterious	0.06	0.35	0.27	neutral	0.91	disease	0.75	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.75	deleterious	-3.78	low_impact	-0.95	medium_impact	2.38	high_impact	0.11	0.8	74.71	11.56	0.45	N	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9504	9504	G	C	MI.7268	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	298	100	A	P	Gcc/Ccc	3.37	1	0	probably_damaging	1	deleterious	0.02	neutral	1.8	deleterious	-4.35	deleterious	-4	high_impact	4.48	0.62	neutral	0.02	damaging	3.79	23.40	deleterious	0.03	0.35	0.55	disease	0.89	disease	0.68	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.78	low_impact	-0.77	medium_impact	2.83	high_impact	0.55	0.8	74.71	11.47	0.49	N	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9504	9504	G	A	MI.7269	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	298	100	A	T	Gcc/Acc	3.37	1	0	probably_damaging	0.99	neutral	0.07	neutral	1.98	neutral	-1.52	deleterious	-2.6	medium_impact	2.05	0.47	damaging	0.06	damaging	3.06	22.40	deleterious	0.1	0.4	0.21	neutral	0.73	disease	0.34	neutral	0.47	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.72	deleterious	-2.81	low_impact	-0.45	medium_impact	0.66	medium_impact	0.63	0.8	74.71	11.47	0.52	P	0.86	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8869	8869	A	C	MI.727	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	343	115	M	L	Ata/Cta	-4.73	0	0.02	benign	0	neutral	0.87	neutral	4.55	neutral	1.7	neutral	0.07	neutral_impact	-0.88	0.91	neutral	0.98	neutral	-0.29	0.69	neutral	0.52	0.65	0.42	neutral	0.47	neutral	0.35	neutral	0.45	neutral	1	0.11	neutral	0.94	deleterious	-6	neutral	0.17	neutral	2.09	high_impact	0.76	medium_impact	-1.85	low_impact	0.48	0.9	21.24	12.41	0.32	N	0.03	polymorphism	1	0.01	rs41432347	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9504	9504	G	T	MI.7270	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	298	100	A	S	Gcc/Tcc	3.37	1	0	probably_damaging	0.99	neutral	0.06	neutral	1.89	neutral	-2.41	neutral	-1.89	medium_impact	2.46	0.47	damaging	0.07	damaging	3.62	23.20	deleterious	0.18	0.45	0.26	neutral	0.71	disease	0.32	neutral	0.47	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.73	deleterious	-2.81	low_impact	-0.49	medium_impact	1.02	medium_impact	0.39	0.8	74.71	11.47	0.52	P	0.89	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9505	9505	C	T	MI.7271	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	299	100	A	V	gCc/gTc	6.14	1	0	probably_damaging	0.99	neutral	0.05	neutral	1.84	deleterious	-3.08	deleterious	-3.26	medium_impact	3.28	0.57	damaging	0.02	damaging	4.39	24.10	deleterious	0.07	0.35	0.38	neutral	0.85	disease	0.56	disease	0.63	disease	3	1	deleterious	0.03	neutral	1	deleterious	0.75	deleterious	-2.81	low_impact	-0.54	medium_impact	1.76	medium_impact	0.67	0.85	74.71	11.47	0.48	N	0.87	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9505	9505	C	G	MI.7272	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	299	100	A	G	gCc/gGc	6.14	1	0	probably_damaging	0.98	neutral	0.12	neutral	1.83	deleterious	-3.25	deleterious	-2.72	medium_impact	2.13	0.48	damaging	0.07	damaging	2.82	21.50	deleterious	0.17	0.45	0.29	neutral	0.75	disease	0.32	neutral	0.48	neutral	1	0.99	deleterious	0.07	neutral	1	deleterious	0.71	deleterious	-2.51	low_impact	-0.3	medium_impact	0.73	medium_impact	0.57	0.8	74.71	11.47	0.49	P	0.67	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9505	9505	C	A	MI.7273	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	299	100	A	D	gCc/gAc	6.14	1	0	probably_damaging	1	deleterious	0.02	neutral	1.8	deleterious	-4.15	deleterious	-4.57	high_impact	4.48	0.64	neutral	0.01	damaging	4.59	24.40	deleterious	0.02	0.35	0.32	neutral	0.92	disease	0.66	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-3.78	low_impact	-0.77	medium_impact	2.83	high_impact	0.35	0.8	74.71	11.47	0.46	N	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9507	9507	T	C	MI.7274	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	301	101	F	L	Ttt/Ctt	-14.68	0	0	probably_damaging	0.97	neutral	0.24	neutral	1.84	neutral	-2.71	deleterious	-4.58	low_impact	1.76	0.6	neutral	0.15	damaging	2.85	21.60	deleterious	0.14	0.4	0.16	neutral	0.72	disease	0.58	disease	0.51	disease	0	0.98	neutral	0.14	neutral	-2	neutral	0.68	deleterious	-2.34	low_impact	-0.09	medium_impact	0.4	medium_impact	0.33	0.8	74.71	11.68	0.26	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9507	9507	T	A	MI.7275	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	301	101	F	I	Ttt/Att	-14.68	0	0	probably_damaging	0.98	neutral	0.08	neutral	1.8	deleterious	-3.49	deleterious	-4.75	high_impact	3.93	0.68	neutral	0.05	damaging	4.33	24.00	deleterious	0.12	0.4	0.19	neutral	0.83	disease	0.66	disease	0.7	disease	4	0.99	deleterious	0.05	neutral	2	deleterious	0.70	deleterious	-2.51	low_impact	-0.41	medium_impact	2.34	high_impact	0.32	0.8	74.71	11.68	0.3	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9507	9507	T	G	MI.7276	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	301	101	F	V	Ttt/Gtt	-14.68	0	0	probably_damaging	0.99	neutral	0.1	neutral	1.81	deleterious	-3.29	deleterious	-5.58	high_impact	4.28	0.67	neutral	0.04	damaging	4.01	23.60	deleterious	0.08	0.35	0.2	neutral	0.83	disease	0.66	disease	0.7	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.68	deleterious	-2.81	low_impact	-0.35	medium_impact	2.65	high_impact	0.25	0.8	74.71	11.68	0.31	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9508	9508	T	G	MI.7277	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	302	101	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	deleterious	0.04	neutral	1.75	deleterious	-5.74	deleterious	-6.62	high_impact	3.73	0.72	neutral	0.03	damaging	4.00	23.60	deleterious	0.05	0.35	0.37	neutral	0.87	disease	0.67	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.73	deleterious	-3.78	low_impact	-0.6	medium_impact	2.16	high_impact	0.20	0.8	74.71	11.68	0.41	N	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9508	9508	T	C	MI.7278	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	302	101	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	neutral	0.21	neutral	1.81	deleterious	-3.41	deleterious	-6.66	medium_impact	3.31	0.59	damaging	0.04	damaging	4.07	23.70	deleterious	0.03	0.35	0.26	neutral	0.78	disease	0.66	disease	0.62	disease	2	1	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.14	medium_impact	1.78	medium_impact	0.35	0.8	74.71	11.68	0.45	N	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9508	9508	T	A	MI.7279	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	302	101	F	Y	tTt/tAt	7.53	1	0	probably_damaging	0.97	neutral	0.24	neutral	2.02	neutral	-1.21	neutral	-2.15	neutral_impact	0.6	0.55	damaging	0.09	damaging	4.02	23.60	deleterious	0.16	0.45	0.11	neutral	0.53	disease	0.43	neutral	0.41	neutral	2	0.98	neutral	0.14	neutral	-2	neutral	0.67	deleterious	-2.34	low_impact	-0.09	medium_impact	-0.65	medium_impact	0.48	0.8	74.71	11.68	0.53	P	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8869	8869	A	T	MI.728	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	343	115	M	L	Ata/Tta	-4.73	0	0.02	benign	0	neutral	0.87	neutral	4.55	neutral	1.7	neutral	0.07	neutral_impact	-0.88	0.91	neutral	0.98	neutral	-0.22	0.98	neutral	0.52	0.65	0.42	neutral	0.47	neutral	0.35	neutral	0.45	neutral	1	0.11	neutral	0.94	deleterious	-6	neutral	0.17	neutral	2.09	high_impact	0.76	medium_impact	-1.85	low_impact	0.48	0.9	21.24	12.41	0.32	N	0.03	polymorphism	1	0.01	rs41432347	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9509	9509	T	G	MI.7280	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	303	101	F	L	ttT/ttG	7.53	1	0	probably_damaging	0.97	neutral	0.24	neutral	1.84	neutral	-2.71	deleterious	-4.58	low_impact	1.76	0.6	neutral	0.15	damaging	3.20	22.70	deleterious	0.14	0.4	0.16	neutral	0.72	disease	0.58	disease	0.51	disease	0	0.98	neutral	0.14	neutral	-2	neutral	0.68	deleterious	-2.34	low_impact	-0.09	medium_impact	0.4	medium_impact	0.33	0.8	74.71	11.68	0.5	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9509	9509	T	A	MI.7281	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	303	101	F	L	ttT/ttA	7.53	1	0	probably_damaging	0.97	neutral	0.24	neutral	1.84	neutral	-2.71	deleterious	-4.58	low_impact	1.76	0.6	neutral	0.15	damaging	3.30	22.90	deleterious	0.14	0.4	0.16	neutral	0.72	disease	0.58	disease	0.51	disease	0	0.98	neutral	0.14	neutral	-2	neutral	0.68	deleterious	-2.34	low_impact	-0.09	medium_impact	0.4	medium_impact	0.33	0.8	74.71	11.68	0.5	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9510	9510	T	C	MI.7282	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	304	102	Y	H	Tac/Cac	-4.27	0	0	probably_damaging	1	neutral	0.57	neutral	2.19	neutral	-2.28	deleterious	-3.97	medium_impact	2.6	0.48	damaging	0.03	damaging	3.50	23.10	deleterious	0.11	0.4	0.48	neutral	0.65	disease	0.67	disease	0.7	disease	4	1	deleterious	0.29	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.26	medium_impact	1.15	medium_impact	0.33	0.8	74.71	11.6	0.23	N	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9510	9510	T	G	MI.7283	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	304	102	Y	D	Tac/Gac	-4.27	0	0	probably_damaging	1	neutral	0.11	neutral	2.17	deleterious	-3.05	deleterious	-6.52	medium_impact	2.6	0.45	damaging	0.02	damaging	3.85	23.40	deleterious	0.04	0.35	0.56	disease	0.82	disease	0.69	disease	0.75	disease	5	1	deleterious	0.06	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	-0.33	medium_impact	1.15	medium_impact	0.22	0.8	74.71	11.6	0.26	N	0.99	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9510	9510	T	A	MI.7284	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	304	102	Y	N	Tac/Aac	-4.27	0	0	probably_damaging	1	neutral	0.1	neutral	2.18	neutral	-2.57	deleterious	-6.25	medium_impact	2.6	0.52	damaging	0.04	damaging	3.92	23.50	deleterious	0.05	0.35	0.45	neutral	0.84	disease	0.61	disease	0.75	disease	5	1	deleterious	0.05	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	-0.35	medium_impact	1.15	medium_impact	0.33	0.8	74.71	11.6	0.24	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9511	9511	A	G	MI.7285	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	305	102	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	neutral	0.06	neutral	2.17	deleterious	-3.67	deleterious	-5.53	medium_impact	2.6	0.48	damaging	0.02	damaging	3.53	23.10	deleterious	0.04	0.35	0.52	disease	0.85	disease	0.62	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	-0.49	medium_impact	1.15	medium_impact	0.27	0.8	74.71	11.6	0.41	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9511	9511	A	C	MI.7286	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	305	102	Y	S	tAc/tCc	7.53	1	0	probably_damaging	0.99	neutral	0.81	neutral	2.22	neutral	-1.32	deleterious	-5.54	low_impact	1.46	0.51	damaging	0.05	damaging	3.68	23.30	deleterious	0.06	0.35	0.23	neutral	0.67	disease	0.6	disease	0.64	disease	3	0.99	deleterious	0.41	neutral	-2	neutral	0.71	deleterious	-2.81	low_impact	0.55	medium_impact	0.13	medium_impact	0.32	0.8	74.71	11.6	0.39	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9511	9511	A	T	MI.7287	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	305	102	Y	F	tAc/tTc	7.53	1	0	probably_damaging	0.96	neutral	1	neutral	2.79	neutral	2.14	neutral	1.1	neutral_impact	-1.86	0.61	neutral	0.35	neutral	1.32	12.38	neutral	0.23	0.45	0.12	neutral	0.09	neutral	0.23	neutral	0.27	neutral	5	0.96	neutral	0.52	deleterious	-2	neutral	0.59	deleterious	-2.21	low_impact	1.9	high_impact	-2.85	low_impact	0.50	0.8	74.71	11.6	0.5	P	0.72	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9513	9513	C	T	MI.7288	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	307	103	H	Y	Cac/Tac	-2.88	0	0	probably_damaging	0.98	neutral	0.76	neutral	2	deleterious	-3.88	deleterious	-4.51	low_impact	1.72	0.55	damaging	0.03	damaging	3.66	23.20	deleterious	0.2	0.45	0.42	neutral	0.82	disease	0.63	disease	0.49	neutral	0	0.98	deleterious	0.39	neutral	-2	neutral	0.77	deleterious	-2.51	low_impact	0.48	medium_impact	0.36	medium_impact	0.18	0.8	73.56	11.77	0.14	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9513	9513	C	G	MI.7289	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	307	103	H	D	Cac/Gac	-2.88	0	0	probably_damaging	0.99	neutral	0.15	neutral	2.14	neutral	-1.19	deleterious	-7.53	medium_impact	2.37	0.55	damaging	0.02	damaging	3.81	23.40	deleterious	0.05	0.35	0.29	neutral	0.78	disease	0.74	disease	0.52	disease	0	1	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-2.81	low_impact	-0.24	medium_impact	0.94	medium_impact	0.32	0.8	73.56	11.77	0.25	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8870	8870	T	C	MI.729	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	344	115	M	T	aTa/aCa	-0.1	0	0	benign	0	neutral	0.53	neutral	4.46	neutral	0.89	neutral	0.15	neutral_impact	-0.57	0.91	neutral	0.97	neutral	-0.86	0.03	neutral	0.48	0.65	0.27	neutral	0.33	neutral	0.39	neutral	0.43	neutral	1	0.47	neutral	0.77	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.32	medium_impact	-1.59	low_impact	0.23	0.9	21.24	12.41	0.25	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9513	9513	C	A	MI.7290	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	307	103	H	N	Cac/Aac	-2.88	0	0	probably_damaging	0.99	neutral	0.28	neutral	2.07	neutral	-1.96	deleterious	-5.69	medium_impact	2.51	0.58	damaging	0.27	damaging	2.80	21.40	deleterious	0.22	0.45	0.31	neutral	0.79	disease	0.65	disease	0.48	neutral	0	0.99	deleterious	0.15	neutral	1	deleterious	0.73	deleterious	-2.81	low_impact	-0.04	medium_impact	1.07	medium_impact	0.35	0.8	73.56	11.77	0.26	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9514	9514	A	T	MI.7291	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	308	103	H	L	cAc/cTc	5.45	1	0	probably_damaging	0.98	neutral	0.6	neutral	2.02	deleterious	-3.08	deleterious	-9.01	medium_impact	3.26	0.53	damaging	0.03	damaging	3.81	23.40	deleterious	0.06	0.35	0.22	neutral	0.89	disease	0.69	disease	0.72	disease	4	0.98	deleterious	0.31	neutral	1	deleterious	0.73	deleterious	-2.51	low_impact	0.29	medium_impact	1.74	medium_impact	0.17	0.8	73.56	11.77	0.4	N	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9514	9514	A	C	MI.7292	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	308	103	H	P	cAc/cCc	5.45	1	0	probably_damaging	1	neutral	0.15	neutral	2.01	deleterious	-3.7	deleterious	-8.53	high_impact	4.3	0.54	damaging	0.05	damaging	3.18	22.70	deleterious	0.04	0.35	0.46	neutral	0.89	disease	0.79	disease	0.72	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.24	medium_impact	2.67	high_impact	0.17	0.8	73.56	11.77	0.57	P	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9514	9514	A	G	MI.7293	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	308	103	H	R	cAc/cGc	5.45	1	0	probably_damaging	0.98	neutral	0.25	neutral	2.04	neutral	-2.51	deleterious	-6.74	high_impact	4.3	0.57	damaging	0.09	damaging	2.93	22.00	deleterious	0.1	0.4	0.3	neutral	0.86	disease	0.73	disease	0.64	disease	3	0.99	deleterious	0.14	neutral	2	deleterious	0.76	deleterious	-2.51	low_impact	-0.08	medium_impact	2.67	high_impact	0.28	0.8	73.56	11.77	0.5	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9515	9515	C	G	MI.7294	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	309	103	H	Q	caC/caG	8.69	1	0	probably_damaging	0.99	neutral	0.22	neutral	2.06	neutral	-2.28	deleterious	-6.7	high_impact	3.75	0.58	damaging	0.03	damaging	3.55	23.10	deleterious	0.11	0.4	0.29	neutral	0.79	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.12	neutral	2	deleterious	0.72	deleterious	-2.81	low_impact	-0.12	medium_impact	2.18	high_impact	0.37	0.8	73.56	11.77	0.44	N	0.94	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9515	9515	C	A	MI.7295	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	309	103	H	Q	caC/caA	8.69	1	0	probably_damaging	0.99	neutral	0.22	neutral	2.06	neutral	-2.28	deleterious	-6.7	high_impact	3.75	0.58	damaging	0.03	damaging	3.77	23.40	deleterious	0.11	0.4	0.29	neutral	0.79	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.12	neutral	2	deleterious	0.72	deleterious	-2.81	low_impact	-0.12	medium_impact	2.18	high_impact	0.37	0.8	73.56	11.77	0.45	N	0.94	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9516	9516	T	C	MI.7296	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	310	104	S	P	Tcc/Ccc	0.13	0.98	0	probably_damaging	1	neutral	0.22	neutral	1.88	deleterious	-4.04	deleterious	-4.05	high_impact	3.9	0.43	damaging	0.04	damaging	4.02	23.60	deleterious	0.05	0.35	0.51	disease	0.87	disease	0.72	disease	0.72	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.12	medium_impact	2.31	high_impact	0.26	0.8	75.1	11.72	0.55	P	0.98	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9516	9516	T	A	MI.7297	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	310	104	S	T	Tcc/Acc	0.13	0.98	0	probably_damaging	0.96	neutral	0.39	neutral	1.94	neutral	-2.64	neutral	-2.13	medium_impact	3	0.44	damaging	0.06	damaging	3.97	23.60	deleterious	0.21	0.45	0.26	neutral	0.69	disease	0.57	disease	0.64	disease	3	0.96	neutral	0.22	neutral	1	deleterious	0.61	deleterious	-2.21	low_impact	0.08	medium_impact	1.51	medium_impact	0.48	0.8	75.1	11.72	0.5	P	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9516	9516	T	G	MI.7298	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	310	104	S	A	Tcc/Gcc	0.13	0.98	0	probably_damaging	0.98	neutral	0.52	neutral	2.03	neutral	-1.51	neutral	-2.11	low_impact	1.39	0.6	damaging	0.36	neutral	2.45	19.13	deleterious	0.24	0.45	0.16	neutral	0.4	neutral	0.27	neutral	0.41	neutral	2	0.97	neutral	0.27	neutral	-2	neutral	0.65	deleterious	-2.51	low_impact	0.21	medium_impact	0.06	medium_impact	0.28	0.8	75.1	11.72	0.41	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9517	9517	C	T	MI.7299	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	311	104	S	F	tCc/tTc	2.21	1	0	probably_damaging	1	neutral	0.73	neutral	1.87	deleterious	-4.89	deleterious	-4.5	low_impact	1.94	0.41	damaging	0.03	damaging	4.24	23.90	deleterious	0.06	0.35	0.18	neutral	0.88	disease	0.39	neutral	0.39	neutral	2	1	deleterious	0.37	neutral	-2	neutral	0.72	deleterious	-3.78	low_impact	0.44	medium_impact	0.56	medium_impact	0.09	0.8	75.1	11.72	0.44	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8558	8558	C	A	MI.73	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	32	11	A	D	gCc/gAc	1.05	0.01	0	possibly_damaging	0.48	neutral	0.11	neutral	4.65	neutral	-0.81	neutral	-1.68	neutral_impact	0	0.8	neutral	0.43	neutral	3.94	23.50	deleterious	0.27	0.65	0.51	disease	0.82	disease	0.56	disease	0.73	disease	5	0.88	neutral	0.32	neutral	-3	neutral	0.61	deleterious	-0.72	medium_impact	-0.22	medium_impact	-1.1	low_impact	0.42	0.9	23.45	19.76	0.33	N	0.80	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8870	8870	T	A	MI.730	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	344	115	M	K	aTa/aAa	-0.1	0	0	benign	0.01	neutral	0.18	neutral	4.34	neutral	-1.43	deleterious	-2.66	low_impact	1.12	0.86	neutral	0.76	neutral	1.95	15.90	deleterious	0.33	0.65	0.67	disease	0.81	disease	0.66	disease	0.72	disease	4	0.82	neutral	0.59	deleterious	-6	neutral	0.29	neutral	1.14	medium_impact	-0.08	medium_impact	-0.14	medium_impact	0.56	0.9	21.24	12.41	0.29	N	0.69	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9517	9517	C	G	MI.7300	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	311	104	S	C	tCc/tGc	2.21	1	0	probably_damaging	1	neutral	0.18	neutral	1.87	deleterious	-5	deleterious	-3.8	medium_impact	3	0.43	damaging	0.03	damaging	3.56	23.10	deleterious	0.06	0.35	0.53	disease	0.85	disease	0.57	disease	0.68	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	-0.18	medium_impact	1.51	medium_impact	0.25	0.8	75.1	11.72	0.44	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9517	9517	C	A	MI.7301	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	311	104	S	Y	tCc/tAc	2.21	1	0	probably_damaging	1	neutral	1	neutral	1.87	deleterious	-4.91	deleterious	-4.58	medium_impact	2.37	0.41	damaging	0.03	damaging	4.06	23.70	deleterious	0.05	0.35	0.3	neutral	0.87	disease	0.62	disease	0.63	disease	3	1	deleterious	0.5	deleterious	1	deleterious	0.75	deleterious	-3.78	low_impact	1.9	high_impact	0.94	medium_impact	0.18	0.8	75.1	11.72	0.44	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9519	9519	A	G	MI.7302	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	313	105	S	G	Agc/Ggc	-5.66	0	0	probably_damaging	0.99	neutral	0.32	neutral	1.98	neutral	-2.66	deleterious	-3.8	medium_impact	3.12	0.48	damaging	0.17	damaging	3.59	23.20	deleterious	0.12	0.4	0.26	neutral	0.65	disease	0.62	disease	0.64	disease	3	0.99	deleterious	0.17	neutral	1	deleterious	0.69	deleterious	-2.81	low_impact	0.01	medium_impact	1.61	medium_impact	0.50	0.8	73.18	11.71	0.34	N	0.83	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9519	9519	A	C	MI.7303	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	313	105	S	R	Agc/Cgc	-5.66	0	0	probably_damaging	1	neutral	0.34	neutral	1.94	deleterious	-3.57	deleterious	-4.75	low_impact	1.75	0.51	damaging	0.04	damaging	3.82	23.40	deleterious	0.09	0.35	0.12	neutral	0.88	disease	0.6	disease	0.65	disease	3	1	deleterious	0.17	neutral	-2	neutral	0.73	deleterious	-3.78	low_impact	0.03	medium_impact	0.39	medium_impact	0.26	0.8	73.18	11.71	0.22	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9519	9519	A	T	MI.7304	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	313	105	S	C	Agc/Tgc	-5.66	0	0	probably_damaging	1	neutral	0.19	neutral	1.93	deleterious	-4.47	deleterious	-4.77	medium_impact	3.24	0.49	damaging	0.05	damaging	3.46	23.00	deleterious	0.06	0.35	0.41	neutral	0.85	disease	0.5	neutral	0.7	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.17	medium_impact	1.72	medium_impact	0.17	0.8	73.18	11.71	0.29	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9520	9520	G	T	MI.7305	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	314	105	S	I	aGc/aTc	8.69	1	0	probably_damaging	1	neutral	0.45	neutral	1.94	deleterious	-3.75	deleterious	-5.7	high_impact	3.73	0.53	damaging	0.07	damaging	4.11	23.70	deleterious	0.05	0.35	0.38	neutral	0.9	disease	0.62	disease	0.71	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	0.14	medium_impact	2.16	high_impact	0.21	0.8	73.18	11.71	0.44	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9520	9520	G	C	MI.7306	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	314	105	S	T	aGc/aCc	8.69	1	0	probably_damaging	0.96	neutral	0.43	neutral	2	neutral	-2.31	deleterious	-2.85	high_impact	4.28	0.54	damaging	0.07	damaging	3.40	23.00	deleterious	0.17	0.45	0.22	neutral	0.71	disease	0.6	disease	0.64	disease	3	0.96	neutral	0.24	neutral	2	deleterious	0.68	deleterious	-2.21	low_impact	0.12	medium_impact	2.65	high_impact	0.32	0.8	73.18	11.71	0.5	N	0.63	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9520	9520	G	A	MI.7307	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	314	105	S	N	aGc/aAc	8.69	1	0	probably_damaging	0.96	neutral	0.32	neutral	1.95	deleterious	-3.24	deleterious	-2.86	high_impact	4.28	0.46	damaging	0.06	damaging	3.58	23.20	deleterious	0.36	0.5	0.23	neutral	0.82	disease	0.61	disease	0.67	disease	3	0.96	neutral	0.18	neutral	2	deleterious	0.70	deleterious	-2.21	low_impact	0.01	medium_impact	2.65	high_impact	0.23	0.8	73.18	11.71	0.55	P	0.88	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9522	9522	C	A	MI.7308	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	316	106	L	M	Cta/Ata	-0.1	0	0	probably_damaging	0.99	neutral	0.22	neutral	1.63	deleterious	-3.12	neutral	-1.75	medium_impact	2.73	0.58	damaging	0.04	damaging	3.69	23.30	deleterious	0.26	0.45	0.29	neutral	0.45	neutral	0.44	neutral	0.4	neutral	2	1	deleterious	0.12	neutral	1	deleterious	0.67	deleterious	-2.81	low_impact	-0.12	medium_impact	1.26	medium_impact	0.50	0.8	73.95	11.57	0.33	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9522	9522	C	G	MI.7309	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	316	106	L	V	Cta/Gta	-0.1	0	0	probably_damaging	0.91	neutral	0.51	neutral	1.67	neutral	-2.72	deleterious	-2.52	medium_impact	2.43	0.5	damaging	0.06	damaging	3.37	22.90	deleterious	0.22	0.45	0.21	neutral	0.6	disease	0.49	neutral	0.43	neutral	1	0.9	neutral	0.3	neutral	1	deleterious	0.52	deleterious	-1.85	low_impact	0.2	medium_impact	1	medium_impact	0.41	0.8	73.95	11.57	0.25	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8871	8871	A	T	MI.731	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	345	115	M	I	atA/atT	-1.03	0	0	benign	0.01	neutral	0.78	neutral	4.44	neutral	0.76	neutral	0.34	neutral_impact	-1.41	0.88	neutral	0.96	neutral	-1.04	0.01	neutral	0.61	0.7	0.34	neutral	0.23	neutral	0.34	neutral	0.41	neutral	2	0.2	neutral	0.89	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.6	medium_impact	-2.31	low_impact	0.46	0.9	21.24	12.41	0.28	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9523	9523	T	A	MI.7310	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	317	106	L	Q	cTa/cAa	-0.1	0	0	probably_damaging	0.99	neutral	0.29	neutral	1.53	deleterious	-5.82	deleterious	-5.41	high_impact	3.64	0.6	damaging	0.02	damaging	4.06	23.70	deleterious	0.04	0.35	0.42	neutral	0.81	disease	0.62	disease	0.66	disease	3	0.99	deleterious	0.15	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	-0.03	medium_impact	2.08	high_impact	0.08	0.8	73.95	11.57	0.26	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9523	9523	T	G	MI.7311	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	317	106	L	R	cTa/cGa	-0.1	0	0	probably_damaging	0.99	neutral	0.35	neutral	1.53	deleterious	-5.84	deleterious	-5.46	high_impact	4.09	0.67	neutral	0.02	damaging	4.16	23.80	deleterious	0.03	0.35	0.42	neutral	0.88	disease	0.69	disease	0.72	disease	4	0.99	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-2.81	low_impact	0.04	medium_impact	2.48	high_impact	0.07	0.8	73.95	11.57	0.29	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9523	9523	T	C	MI.7312	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	317	106	L	P	cTa/cCa	-0.1	0	0	probably_damaging	1	neutral	0.22	neutral	1.53	deleterious	-6.51	deleterious	-6.34	high_impact	3.75	0.53	damaging	0.04	damaging	3.89	23.50	deleterious	0.03	0.35	0.56	disease	0.8	disease	0.62	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.12	medium_impact	2.18	high_impact	0.10	0.8	73.95	11.57	0.27	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9525	9525	G	T	MI.7313	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	319	107	A	S	Gcc/Tcc	-2.42	0	0	probably_damaging	0.98	neutral	0.82	neutral	2.33	neutral	0.04	neutral	-0.46	neutral_impact	-0.02	0.64	neutral	0.73	neutral	0.57	7.92	deleterious	0.21	0.45	0.11	neutral	0.12	neutral	0.13	neutral	0.25	neutral	5	0.98	deleterious	0.42	neutral	-2	neutral	0.61	deleterious	-2.51	low_impact	0.57	medium_impact	-1.2	low_impact	0.31	0.8	33.72	16.42	0.36	N	0.33	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9525	9525	G	C	MI.7314	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	319	107	A	P	Gcc/Ccc	-2.42	0	0	probably_damaging	1	neutral	0.34	neutral	2.1	deleterious	-3.15	deleterious	-3.28	medium_impact	3.23	0.54	damaging	0.36	neutral	3.69	23.30	deleterious	0.06	0.35	0.42	neutral	0.83	disease	0.48	neutral	0.72	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	0.03	medium_impact	1.71	medium_impact	0.28	0.8	33.72	16.42	0.35	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9525	9525	G	A	MI.7315	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	319	107	A	T	Gcc/Acc	-2.42	0	0	probably_damaging	0.99	neutral	0.59	neutral	2.17	neutral	-1.37	neutral	-1.85	low_impact	1.44	0.64	neutral	0.66	neutral	2.24	17.78	deleterious	0.19	0.45	0.17	neutral	0.56	disease	0.22	neutral	0.42	neutral	2	0.98	deleterious	0.3	neutral	-2	neutral	0.66	deleterious	-2.81	low_impact	0.28	medium_impact	0.11	medium_impact	0.48	0.8	33.72	16.42	0.33	N	0.41	polymorphism	1	0.03	rs878977410	.	.	.	.	.	COSM6716211	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9526	9526	C	T	MI.7316	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	320	107	A	V	gCc/gTc	5.22	1	0	probably_damaging	0.98	neutral	0.33	neutral	2.2	neutral	-1.01	deleterious	-2.8	low_impact	0.98	0.64	neutral	0.71	neutral	1.66	14.18	neutral	0.13	0.4	0.16	neutral	0.54	disease	0.25	neutral	0.43	neutral	1	0.98	deleterious	0.18	neutral	-2	neutral	0.67	deleterious	-2.51	low_impact	0.02	medium_impact	-0.3	medium_impact	0.54	0.8	33.72	16.42	0.51	P	0.11	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9526	9526	C	G	MI.7317	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	320	107	A	G	gCc/gGc	5.22	1	0	probably_damaging	0.95	neutral	0.39	neutral	2.12	neutral	-2.29	neutral	-2.39	low_impact	1.54	0.63	neutral	0.62	neutral	2.27	17.98	deleterious	0.22	0.45	0.33	neutral	0.5	neutral	0.37	neutral	0.46	neutral	1	0.95	neutral	0.22	neutral	-2	neutral	0.66	deleterious	-2.11	low_impact	0.08	medium_impact	0.2	medium_impact	0.56	0.8	33.72	16.42	0.5	N	0.60	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9526	9526	C	A	MI.7318	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	320	107	A	D	gCc/gAc	5.22	1	0	probably_damaging	1	neutral	0.63	neutral	2.11	neutral	-2.66	deleterious	-3.32	medium_impact	2.6	0.61	neutral	0.4	neutral	4.43	24.20	deleterious	0.05	0.35	0.28	neutral	0.81	disease	0.59	disease	0.66	disease	3	1	deleterious	0.32	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	0.32	medium_impact	1.15	medium_impact	0.16	0.8	33.72	16.42	0.43	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9528	9528	C	G	MI.7319	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	322	108	P	A	Cct/Gct	-7.97	0	0	probably_damaging	0.99	neutral	1	neutral	1.05	deleterious	-4.98	deleterious	-7.54	medium_impact	2.48	0.64	neutral	0.04	damaging	3.07	22.40	deleterious	0.17	0.45	0.31	neutral	0.55	disease	0.55	disease	0.53	disease	1	0.99	deleterious	0.51	deleterious	1	deleterious	0.72	deleterious	-2.81	low_impact	1.9	high_impact	1.04	medium_impact	0.39	0.8	73.56	11.63	0.16	N	0.70	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8871	8871	A	C	MI.732	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	345	115	M	I	atA/atC	-1.03	0	0	benign	0.01	neutral	0.78	neutral	4.44	neutral	0.76	neutral	0.34	neutral_impact	-1.41	0.88	neutral	0.96	neutral	-1.15	0.01	neutral	0.61	0.7	0.34	neutral	0.23	neutral	0.34	neutral	0.41	neutral	2	0.2	neutral	0.89	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.6	medium_impact	-2.31	low_impact	0.46	0.9	21.24	12.41	0.28	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9528	9528	C	T	MI.7320	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	322	108	P	S	Cct/Tct	-7.97	0	0	probably_damaging	1	neutral	0.76	neutral	1.04	deleterious	-5.25	deleterious	-7.52	medium_impact	2.1	0.67	neutral	0.02	damaging	3.89	23.50	deleterious	0.21	0.45	0.32	neutral	0.64	disease	0.54	disease	0.43	neutral	2	1	deleterious	0.38	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	0.48	medium_impact	0.7	medium_impact	0.03	0.8	73.56	11.63	0.17	N	0.79	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9528	9528	C	A	MI.7321	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	322	108	P	T	Cct/Act	-7.97	0	0	probably_damaging	1	neutral	0.51	neutral	1.02	deleterious	-5.67	deleterious	-7.54	medium_impact	2.1	0.63	neutral	0.02	damaging	3.72	23.30	deleterious	0.17	0.45	0.22	neutral	0.71	disease	0.54	disease	0.55	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	0.2	medium_impact	0.7	medium_impact	0.30	0.8	73.56	11.63	0.19	N	0.93	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9529	9529	C	T	MI.7322	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	323	108	P	L	cCt/cTt	7.3	1	0	probably_damaging	1	neutral	0.87	neutral	1.01	deleterious	-6	deleterious	-9.46	medium_impact	3.2	0.64	neutral	0.02	damaging	4.27	24.00	deleterious	0.13	0.4	0.44	neutral	0.75	disease	0.62	disease	0.6	disease	2	1	deleterious	0.44	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.66	medium_impact	1.69	medium_impact	0.57	0.8	73.56	11.63	0.36	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9529	9529	C	G	MI.7323	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	323	108	P	R	cCt/cGt	7.3	1	0	probably_damaging	1	neutral	0.31	neutral	1.01	deleterious	-6.18	deleterious	-8.5	high_impact	4.09	0.75	neutral	0.01	damaging	3.57	23.10	deleterious	0.08	0.35	0.4	neutral	0.78	disease	0.72	disease	0.65	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.01	medium_impact	2.48	high_impact	0.17	0.8	73.56	11.63	0.47	N	0.93	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9529	9529	C	A	MI.7324	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	323	108	P	H	cCt/cAt	7.3	1	0	probably_damaging	1	neutral	0.47	neutral	0.99	deleterious	-7.29	deleterious	-8.5	medium_impact	3.06	0.62	neutral	0.02	damaging	3.91	23.50	deleterious	0.09	0.35	0.39	neutral	0.76	disease	0.71	disease	0.71	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	0.16	medium_impact	1.56	medium_impact	0.15	0.8	73.56	11.63	0.36	N	0.88	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9531	9531	A	C	MI.7325	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	325	109	T	P	Acc/Ccc	-10.28	0	0	probably_damaging	0.99	neutral	0.25	neutral	2.16	neutral	-2.63	deleterious	-3.97	medium_impact	2.69	0.54	damaging	0.39	neutral	4.00	23.60	deleterious	0.1	0.4	0.37	neutral	0.63	disease	0.5	neutral	0.51	disease	0	1	deleterious	0.13	neutral	1	deleterious	0.70	deleterious	-2.81	low_impact	-0.08	medium_impact	1.23	medium_impact	0.16	0.8	75.86	10.85	0.38	N	0.98	polymorphism	1	0.08	rs386829082	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9531	9531	A	T	MI.7326	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	325	109	T	S	Acc/Tcc	-10.28	0	0	probably_damaging	0.96	neutral	0.42	neutral	2.3	neutral	-0.19	neutral	-1.34	neutral_impact	0.45	0.65	neutral	0.72	neutral	2.64	20.50	deleterious	0.31	0.45	0.14	neutral	0.11	neutral	0.2	neutral	0.29	neutral	4	0.96	neutral	0.23	neutral	-2	neutral	0.61	deleterious	-2.21	low_impact	0.11	medium_impact	-0.78	medium_impact	0.33	0.8	75.86	10.85	0.41	N	0.77	polymorphism	1	0.03	rs386829082	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9531	9531	A	G	MI.7327	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	325	109	T	A	Acc/Gcc	-10.28	0	0	probably_damaging	0.96	neutral	0.52	neutral	2.32	neutral	-0.01	neutral	-2.37	low_impact	1.61	0.72	neutral	0.77	neutral	2.90	21.80	deleterious	0.22	0.45	0.1	neutral	0.17	neutral	0.25	neutral	0.28	neutral	4	0.95	neutral	0.28	neutral	-2	neutral	0.60	deleterious	-2.21	low_impact	0.21	medium_impact	0.26	medium_impact	0.20	0.8	75.86	10.85	0.36	N	0.44	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9532	9532	C	T	MI.7328	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	326	109	T	I	aCc/aTc	7.07	1	0	probably_damaging	1	neutral	0.42	neutral	2.18	neutral	-2.06	deleterious	-4.23	medium_impact	1.96	0.65	neutral	0.52	neutral	3.94	23.50	deleterious	0.12	0.4	0.35	neutral	0.5	neutral	0.55	disease	0.58	disease	2	1	deleterious	0.21	neutral	1	deleterious	0.69	deleterious	-3.78	low_impact	0.11	medium_impact	0.57	medium_impact	0.22	0.8	75.86	10.85	0.45	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9532	9532	C	G	MI.7329	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	326	109	T	S	aCc/aGc	7.07	1	0	probably_damaging	0.96	neutral	0.42	neutral	2.3	neutral	-0.19	neutral	-1.34	neutral_impact	0.45	0.65	neutral	0.72	neutral	2.29	18.11	deleterious	0.31	0.45	0.14	neutral	0.11	neutral	0.2	neutral	0.29	neutral	4	0.96	neutral	0.23	neutral	-2	neutral	0.61	deleterious	-2.21	low_impact	0.11	medium_impact	-0.78	medium_impact	0.33	0.8	75.86	10.85	0.57	P	0.77	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8872	8872	G	C	MI.733	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	346	116	G	R	Ggc/Cgc	-3.34	0	0	possibly_damaging	0.87	neutral	0.06	neutral	3.85	deleterious	-3.96	deleterious	-7.44	high_impact	3.7	0.43	damaging	0.24	damaging	3.75	23.30	deleterious	0.17	0.65	0.98	disease	0.94	disease	0.82	disease	0.75	disease	5	0.97	neutral	0.1	neutral	1	deleterious	0.90	deleterious	-1.54	low_impact	-0.38	medium_impact	2.07	high_impact	0.88	0.9	49.56	8.7	0.53	P	0.98	disease_causing	0.95	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9532	9532	C	A	MI.7330	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	326	109	T	N	aCc/aAc	7.07	1	0	probably_damaging	0.99	neutral	0.31	neutral	2.22	neutral	-1.19	deleterious	-2.71	neutral_impact	0.72	0.67	neutral	0.72	neutral	3.55	23.10	deleterious	0.27	0.45	0.19	neutral	0.35	neutral	0.25	neutral	0.45	neutral	1	0.99	deleterious	0.16	neutral	-2	neutral	0.65	deleterious	-2.81	low_impact	-0.01	medium_impact	-0.54	medium_impact	0.29	0.8	75.86	10.85	0.54	P	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9534	9534	C	G	MI.7331	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	328	110	P	A	Ccc/Gcc	-13.06	0	0	probably_damaging	0.98	neutral	0.77	neutral	2.4	neutral	-1.55	neutral	-1.88	low_impact	1.7	0.56	damaging	0.08	damaging	1.97	16.00	deleterious	0.25	0.45	0.13	neutral	0.18	neutral	0.32	neutral	0.31	neutral	4	0.98	deleterious	0.4	neutral	-2	neutral	0.63	deleterious	-2.51	low_impact	0.49	medium_impact	0.34	medium_impact	0.37	0.8	20.69	26.12	0.23	N	0.65	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9534	9534	C	A	MI.7332	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	328	110	P	T	Ccc/Acc	-13.06	0	0	probably_damaging	1	neutral	0.6	neutral	2.37	neutral	-1.94	neutral	-1.86	low_impact	1.47	0.55	damaging	0.05	damaging	2.60	20.20	deleterious	0.32	0.5	0.15	neutral	0.27	neutral	0.32	neutral	0.44	neutral	1	1	deleterious	0.3	neutral	-2	neutral	0.64	deleterious	-3.78	low_impact	0.29	medium_impact	0.14	medium_impact	0.28	0.8	20.69	26.12	0.23	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9534	9534	C	T	MI.7333	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	328	110	P	S	Ccc/Tcc	-13.06	0	0	probably_damaging	1	neutral	0.63	neutral	2.36	neutral	-1.73	neutral	-2.41	low_impact	1.88	0.54	damaging	0.05	damaging	3.81	23.40	deleterious	0.29	0.45	0.15	neutral	0.26	neutral	0.3	neutral	0.43	neutral	1	1	deleterious	0.32	neutral	-2	neutral	0.64	deleterious	-3.78	low_impact	0.32	medium_impact	0.5	medium_impact	0.11	0.8	20.69	26.12	0.21	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9535	9535	C	T	MI.7334	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	329	110	P	L	cCc/cTc	4.52	0.97	0	probably_damaging	1	neutral	0.8	neutral	2.45	neutral	-2.33	neutral	-1.61	medium_impact	2	0.57	damaging	0.08	damaging	3.25	22.80	deleterious	0.2	0.45	0.13	neutral	0.35	neutral	0.33	neutral	0.44	neutral	1	1	deleterious	0.4	neutral	1	deleterious	0.64	deleterious	-3.78	low_impact	0.54	medium_impact	0.61	medium_impact	0.24	0.8	20.69	26.12	0.36	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9535	9535	C	G	MI.7335	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	329	110	P	R	cCc/cGc	4.52	0.97	0	probably_damaging	1	neutral	0.51	neutral	2.33	neutral	-2.09	deleterious	-3.17	medium_impact	3.42	0.5	damaging	0.04	damaging	3.56	23.10	deleterious	0.14	0.4	0.19	neutral	0.48	neutral	0.46	neutral	0.49	neutral	0	1	deleterious	0.26	neutral	1	deleterious	0.68	deleterious	-3.78	low_impact	0.2	medium_impact	1.88	medium_impact	0.29	0.8	20.69	26.12	0.44	N	0.86	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9535	9535	C	A	MI.7336	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	329	110	P	H	cCc/cAc	4.52	0.97	0	probably_damaging	1	neutral	0.63	neutral	2.33	neutral	-2.74	deleterious	-2.54	low_impact	1.32	0.56	damaging	0.09	damaging	2.84	21.50	deleterious	0.15	0.45	0.15	neutral	0.35	neutral	0.28	neutral	0.45	neutral	1	1	deleterious	0.32	neutral	-2	neutral	0.65	deleterious	-3.78	low_impact	0.32	medium_impact	0	medium_impact	0.18	0.8	20.69	26.12	0.36	N	0.22	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9537	9537	C	A	MI.7337	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	331	111	Q	K	Caa/Aaa	-13.29	0	0	benign	0.01	neutral	0.91	neutral	2.34	neutral	0.35	neutral	-1.1	neutral_impact	0.7	0.57	damaging	0.24	damaging	2.05	16.52	deleterious	0.31	0.5	0.09	neutral	0.32	neutral	0.56	disease	0.43	neutral	2	0.05	neutral	0.95	deleterious	-6	neutral	0.15	neutral	1.07	medium_impact	0.76	medium_impact	-0.56	medium_impact	0.11	0.8	23.37	58.38	0.28	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9537	9537	C	G	MI.7338	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	331	111	Q	E	Caa/Gaa	-13.29	0	0	benign	0.02	neutral	1	neutral	2.79	neutral	3.06	neutral	2.16	neutral_impact	-3.04	0.76	neutral	0.94	neutral	-1.53	0.00	neutral	0.38	0.5	0.12	neutral	0.04	neutral	0.19	neutral	0.23	neutral	5	0.02	neutral	0.99	deleterious	-6	neutral	0.10	neutral	0.77	medium_impact	1.9	high_impact	-3.91	low_impact	0.12	0.8	23.37	58.38	0.39	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9538	9538	A	C	MI.7339	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	332	111	Q	P	cAa/cCa	3.6	1	0	benign	0.08	neutral	0.28	neutral	2.27	neutral	-1.39	deleterious	-2.63	neutral_impact	0	0.48	damaging	0.14	damaging	1.33	12.45	neutral	0.12	0.4	0.26	neutral	0.62	disease	0.51	disease	0.52	disease	0	0.69	neutral	0.6	deleterious	-6	neutral	0.27	neutral	0.16	medium_impact	-0.04	medium_impact	-1.18	low_impact	0.12	0.8	23.37	58.38	0.49	N	0.67	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8872	8872	G	A	MI.734	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	346	116	G	S	Ggc/Agc	-3.34	0	0	benign	0.1	neutral	0.1	neutral	3.97	deleterious	-3.5	deleterious	-5.54	medium_impact	2.5	0.44	damaging	0.37	neutral	2.24	17.79	deleterious	0.27	0.65	0.81	disease	0.86	disease	0.66	disease	0.51	disease	0	0.89	neutral	0.5	deleterious	-3	neutral	0.38	neutral	0.15	medium_impact	-0.25	medium_impact	1.05	medium_impact	0.77	0.9	49.56	8.7	0.45	N	0.98	disease_causing	0.9	0.18	rs28410452	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9538	9538	A	T	MI.7340	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	332	111	Q	L	cAa/cTa	3.6	1	0	benign	0.02	neutral	0.34	neutral	2.28	neutral	-1.09	deleterious	-4.55	neutral_impact	0.2	0.62	neutral	0.24	damaging	1.89	15.55	deleterious	0.14	0.4	0.19	neutral	0.35	neutral	0.49	neutral	0.4	neutral	2	0.65	neutral	0.66	deleterious	-6	neutral	0.16	neutral	0.77	medium_impact	0.03	medium_impact	-1	low_impact	0.04	0.8	23.37	58.38	0.47	N	0.57	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9538	9538	A	G	MI.7341	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	332	111	Q	R	cAa/cGa	3.6	1	0	benign	0	neutral	0.53	neutral	2.3	neutral	-0.45	neutral	-1.94	neutral_impact	-0.04	0.53	damaging	0.22	damaging	1.50	13.30	neutral	0.3	0.45	0.13	neutral	0.42	neutral	0.59	disease	0.41	neutral	2	0.47	neutral	0.77	deleterious	-6	neutral	0.17	neutral	2.05	high_impact	0.22	medium_impact	-1.22	low_impact	0.04	0.8	23.37	58.38	0.48	N	0.42	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9539	9539	A	T	MI.7342	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	333	111	Q	H	caA/caT	7.07	1	0	benign	0	neutral	0.17	neutral	2.28	neutral	-1.25	neutral	-1.96	neutral_impact	0.7	0.63	neutral	0.42	neutral	1.80	14.98	neutral	0.33	0.5	0.23	neutral	0.24	neutral	0.43	neutral	0.38	neutral	2	0.83	neutral	0.59	deleterious	-6	neutral	0.15	neutral	2.05	high_impact	-0.2	medium_impact	-0.56	medium_impact	0.09	0.8	23.37	58.38	0.66	P	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9539	9539	A	C	MI.7343	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	333	111	Q	H	caA/caC	7.07	1	0	benign	0	neutral	0.17	neutral	2.28	neutral	-1.25	neutral	-1.96	neutral_impact	0.7	0.63	neutral	0.42	neutral	1.50	13.29	neutral	0.33	0.5	0.23	neutral	0.24	neutral	0.43	neutral	0.38	neutral	2	0.83	neutral	0.59	deleterious	-6	neutral	0.15	neutral	2.05	high_impact	-0.2	medium_impact	-0.56	medium_impact	0.09	0.8	23.37	58.38	0.66	P	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9540	9540	T	G	MI.7344	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	334	112	L	V	Tta/Gta	0.82	0.13	0.71	probably_damaging	0.95	neutral	0.59	neutral	2.04	neutral	-1.26	neutral	-1.38	low_impact	1.64	0.64	neutral	0.19	damaging	1.68	14.31	neutral	0.34	0.5	0.18	neutral	0.27	neutral	0.32	neutral	0.43	neutral	1	0.94	neutral	0.32	neutral	-2	neutral	0.62	deleterious	-2.11	low_impact	0.28	medium_impact	0.29	medium_impact	0.22	0.8	18.77	32.97	0.27	N	0.81	polymorphism	1	0.02	rs2248727	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9540	9540	T	A	MI.7345	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	334	112	L	M	Tta/Ata	0.82	0.13	0.71	probably_damaging	1	neutral	0.25	neutral	1.86	deleterious	-3.25	neutral	-1.48	medium_impact	2.9	0.6	damaging	0.04	damaging	3.68	23.30	deleterious	0.3	0.45	0.29	neutral	0.27	neutral	0.52	disease	0.47	neutral	1	1	deleterious	0.13	neutral	1	deleterious	0.67	deleterious	-3.78	low_impact	-0.08	medium_impact	1.42	medium_impact	0.38	0.8	18.77	32.97	0.4	N	0.85	polymorphism	1	0.03	rs2248727	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9541	9541	T	G	MI.7346	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	335	112	L	W	tTa/tGa	-1.03	0	0	probably_damaging	1	neutral	0.2	neutral	1.81	deleterious	-6.38	deleterious	-5.19	high_impact	3.75	0.59	damaging	0.03	damaging	3.76	23.30	deleterious	0.08	0.35	0.64	disease	0.52	disease	0.67	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	-0.15	medium_impact	2.18	high_impact	0.18	0.8	18.77	32.97	0.32	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9541	9541	T	C	MI.7347	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	335	112	L	S	tTa/tCa	-1.03	0	0	probably_damaging	1	neutral	0.66	neutral	1.83	deleterious	-4.14	deleterious	-4.74	medium_impact	3	0.56	damaging	0.02	damaging	3.63	23.20	deleterious	0.04	0.35	0.32	neutral	0.52	disease	0.65	disease	0.66	disease	3	1	deleterious	0.33	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	0.36	medium_impact	1.51	medium_impact	0.18	0.8	18.77	32.97	0.22	N	0.92	polymorphism	1	0.09	rs879143185	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9542	9542	A	T	MI.7348	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	336	112	L	F	ttA/ttT	7.53	0.99	0	probably_damaging	0.99	neutral	0.71	neutral	1.85	deleterious	-3.53	deleterious	-3.06	medium_impact	2.9	0.58	damaging	0.03	damaging	3.51	23.10	deleterious	0.28	0.45	0.28	neutral	0.44	neutral	0.64	disease	0.49	neutral	0	0.99	deleterious	0.36	neutral	1	deleterious	0.68	deleterious	-2.81	low_impact	0.41	medium_impact	1.42	medium_impact	0.36	0.8	18.77	32.97	0.47	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9542	9542	A	C	MI.7349	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	336	112	L	F	ttA/ttC	7.53	0.99	0	probably_damaging	0.99	neutral	0.71	neutral	1.85	deleterious	-3.53	deleterious	-3.06	medium_impact	2.9	0.58	damaging	0.03	damaging	3.43	23.00	deleterious	0.28	0.45	0.28	neutral	0.44	neutral	0.64	disease	0.49	neutral	0	0.99	deleterious	0.36	neutral	1	deleterious	0.68	deleterious	-2.81	low_impact	0.41	medium_impact	1.42	medium_impact	0.36	0.8	18.77	32.97	0.47	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8872	8872	G	T	MI.735	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	346	116	G	C	Ggc/Tgc	-3.34	0	0	probably_damaging	0.95	deleterious	0.03	neutral	3.84	deleterious	-6.43	deleterious	-8.35	medium_impact	3.23	0.47	damaging	0.23	damaging	4.01	23.60	deleterious	0.18	0.65	0.97	disease	0.94	disease	0.74	disease	0.72	disease	4	0.99	deleterious	0.04	neutral	5	deleterious	0.91	deleterious	-1.97	low_impact	-0.56	medium_impact	1.67	medium_impact	0.68	0.9	49.56	8.7	0.33	N	1.00	disease_causing	0.97	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9543	9543	G	T	MI.7350	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	337	113	G	W	Gga/Tga	-0.1	0.79	0	probably_damaging	1	neutral	0.19	neutral	1.63	deleterious	-7.62	deleterious	-7.61	high_impact	4.53	0.65	neutral	0.02	damaging	4.46	24.20	deleterious	0.09	0.35	0.3	neutral	0.76	disease	0.77	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	-0.17	medium_impact	2.88	high_impact	0.04	0.8	73.56	11.53	0.39	N	0.98	polymorphism	1	0.16	rs28635722	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9543	9543	G	C	MI.7351	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	337	113	G	R	Gga/Cga	-0.1	0.79	0	probably_damaging	1	neutral	0.35	neutral	1.67	deleterious	-4.38	deleterious	-7.6	high_impact	4.18	0.68	neutral	0.02	damaging	3.95	23.60	deleterious	0.07	0.35	0.22	neutral	0.76	disease	0.78	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	0.04	medium_impact	2.56	high_impact	0.36	0.8	73.56	11.53	0.41	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9544	9544	G	C	MI.7352	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	338	113	G	A	gGa/gCa	8.92	1	0	probably_damaging	1	neutral	0.52	neutral	1.74	neutral	-2.87	deleterious	-5.69	medium_impact	2.96	0.56	damaging	0	damaging	3.12	22.60	deleterious	0.17	0.45	0.13	neutral	0.52	disease	0.59	disease	0.54	disease	1	1	deleterious	0.26	neutral	1	deleterious	0.71	deleterious	-3.78	low_impact	0.21	medium_impact	1.47	medium_impact	0.17	0.8	73.56	11.53	0.4	N	0.30	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9544	9544	G	T	MI.7353	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	338	113	G	V	gGa/gTa	8.92	1	0	probably_damaging	1	neutral	0.51	neutral	1.67	deleterious	-4.34	deleterious	-8.54	high_impact	3.98	0.54	damaging	0.01	damaging	3.76	23.30	deleterious	0.07	0.35	0.21	neutral	0.76	disease	0.71	disease	0.7	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.74	deleterious	-3.78	low_impact	0.2	medium_impact	2.38	high_impact	0.07	0.8	73.56	11.53	0.46	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9544	9544	G	A	MI.7354	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	338	113	G	E	gGa/gAa	8.92	1	0	probably_damaging	1	neutral	0.29	neutral	1.71	deleterious	-3.43	deleterious	-7.6	high_impact	3.73	0.58	damaging	0.01	damaging	3.89	23.50	deleterious	0.08	0.35	0.18	neutral	0.75	disease	0.77	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	-0.03	medium_impact	2.16	high_impact	0.16	0.8	73.56	11.53	0.64	P	1.00	polymorphism	1	0.14	.	.	.	.	.	colonic crypts	.	.	.	G9544A	Sporadic bilateral optic neuropathy	.	.	Reported	1	.	P	P	damaging
chrM	9546	9546	G	C	MI.7355	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	340	114	G	R	Ggg/Cgg	-6.58	0	0	possibly_damaging	0.9	neutral	0.37	neutral	2.5	neutral	-1.81	neutral	-1.15	medium_impact	2.86	0.61	neutral	0.04	damaging	2.87	21.70	deleterious	0.1	0.4	0.19	neutral	0.61	disease	0.47	neutral	0.5	neutral	0	0.9	neutral	0.24	neutral	0	NA	0.68	deleterious	-1.8	low_impact	0.06	medium_impact	1.38	medium_impact	0.43	0.8	73.56	10.38	0.28	N	0.99	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9546	9546	G	T	MI.7356	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	340	114	G	W	Ggg/Tgg	-6.58	0	0	probably_damaging	0.93	neutral	0.32	neutral	2.46	deleterious	-4.73	neutral	-1.87	medium_impact	3.4	0.64	neutral	0.05	damaging	4.50	24.30	deleterious	0.11	0.4	0.62	disease	0.6	disease	0.47	neutral	0.48	neutral	0	0.94	neutral	0.2	neutral	1	deleterious	0.73	deleterious	-1.96	low_impact	0.01	medium_impact	1.86	medium_impact	0.10	0.8	73.56	10.38	0.28	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9547	9547	G	T	MI.7357	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	341	114	G	V	gGg/gTg	4.52	1	0	possibly_damaging	0.62	neutral	0.53	neutral	2.54	neutral	-2.4	neutral	0.03	medium_impact	2.08	0.71	neutral	0.15	damaging	2.54	19.71	deleterious	0.13	0.4	0.18	neutral	0.46	neutral	0.37	neutral	0.44	neutral	1	0.59	neutral	0.46	neutral	0	NA	0.58	deleterious	-1.08	low_impact	0.22	medium_impact	0.68	medium_impact	0.07	0.8	73.56	10.38	0.46	N	0.97	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9547	9547	G	A	MI.7358	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	341	114	G	E	gGg/gAg	4.52	1	0	possibly_damaging	0.9	neutral	0.35	neutral	2.52	neutral	-0.97	neutral	-1.14	low_impact	1.49	0.66	neutral	0.39	neutral	2.40	18.82	deleterious	0.11	0.4	0.11	neutral	0.51	disease	0.44	neutral	0.43	neutral	1	0.91	neutral	0.23	neutral	-3	neutral	0.64	deleterious	-1.8	low_impact	0.04	medium_impact	0.15	medium_impact	0.13	0.8	73.56	10.38	0.54	P	1.00	polymorphism	1	0.02	.	.	.	.	.	cloned platelet mtDNA	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9547	9547	G	C	MI.7359	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	341	114	G	A	gGg/gCg	4.52	1	0	benign	0.1	neutral	0.58	neutral	2.62	neutral	-0.25	neutral	0.85	neutral_impact	0.68	0.68	neutral	0.76	neutral	1.27	12.13	neutral	0.24	0.45	0.08	neutral	0.13	neutral	0.16	neutral	0.26	neutral	5	0.33	neutral	0.74	deleterious	-6	neutral	0.25	neutral	0.06	medium_impact	0.27	medium_impact	-0.57	medium_impact	0.24	0.8	73.56	10.38	0.51	P	0.30	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8873	8873	G	T	MI.736	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	347	116	G	V	gGc/gTc	9.15	1	0	possibly_damaging	0.87	deleterious	0.01	neutral	3.89	deleterious	-3.82	deleterious	-8.35	medium_impact	3.36	0.44	damaging	0.28	neutral	3.61	23.20	deleterious	0.16	0.65	0.95	disease	0.94	disease	0.75	disease	0.73	disease	5	1	deleterious	0.07	neutral	4	deleterious	0.88	deleterious	-1.54	low_impact	-0.84	medium_impact	1.78	medium_impact	0.63	0.9	49.56	8.7	0.62	P	0.99	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9549	9549	C	A	MI.7360	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	343	115	H	N	Cac/Aac	-11.67	0	0	probably_damaging	0.97	neutral	0.31	neutral	2.6	neutral	-0.16	neutral	0.43	neutral_impact	-0.97	0.76	neutral	0.85	neutral	2.16	17.23	deleterious	0.4	0.5	0.07	neutral	0.19	neutral	0.39	neutral	0.33	neutral	3	0.97	neutral	0.17	neutral	-2	neutral	0.59	deleterious	-2.34	low_impact	-0.01	medium_impact	-2.05	low_impact	0.28	0.8	22.61	51.84	0.38	N	0.52	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9549	9549	C	T	MI.7361	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	343	115	H	Y	Cac/Tac	-11.67	0	0	probably_damaging	0.97	neutral	1	neutral	2.61	neutral	-2.29	neutral	-0.31	neutral_impact	0.06	0.78	neutral	0.92	neutral	-0.17	1.27	neutral	0.36	0.5	0.14	neutral	0.17	neutral	0.43	neutral	0.28	neutral	4	0.97	neutral	0.52	deleterious	-2	neutral	0.62	deleterious	-2.34	low_impact	1.9	high_impact	-1.13	low_impact	0.18	0.8	22.61	51.84	0.23	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9549	9549	C	G	MI.7362	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	343	115	H	D	Cac/Gac	-11.67	0	0	probably_damaging	0.98	neutral	0.2	neutral	2.58	neutral	-0.54	neutral	-0.3	neutral_impact	-0.32	0.66	neutral	0.49	neutral	2.31	18.25	deleterious	0.11	0.4	0.1	neutral	0.25	neutral	0.55	disease	0.44	neutral	1	0.99	deleterious	0.11	neutral	-2	neutral	0.62	deleterious	-2.51	low_impact	-0.15	medium_impact	-1.47	low_impact	0.39	0.8	22.61	51.84	0.4	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9550	9550	A	T	MI.7363	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	344	115	H	L	cAc/cTc	1.98	0.09	0	probably_damaging	0.98	neutral	0.65	neutral	2.69	neutral	-0.92	neutral	0.1	neutral_impact	-0.73	0.76	neutral	0.77	neutral	0.24	5.11	deleterious	0.12	0.4	0.06	neutral	0.21	neutral	0.42	neutral	0.33	neutral	4	0.98	neutral	0.34	neutral	-2	neutral	0.61	deleterious	-2.51	low_impact	0.35	medium_impact	-1.84	low_impact	0.09	0.8	22.61	51.84	0.34	N	0.54	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9550	9550	A	C	MI.7364	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	344	115	H	P	cAc/cCc	1.98	0.09	0	probably_damaging	0.99	neutral	0.22	neutral	2.59	neutral	-1.07	neutral	-0.75	neutral_impact	-0.64	0.6	damaging	0.36	neutral	1.96	15.96	deleterious	0.12	0.4	0.16	neutral	0.53	disease	0.5	neutral	0.46	neutral	1	0.99	deleterious	0.12	neutral	-2	neutral	0.68	deleterious	-2.81	low_impact	-0.12	medium_impact	-1.76	low_impact	0.19	0.8	22.61	51.84	0.38	N	0.82	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9550	9550	A	G	MI.7365	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	344	115	H	R	cAc/cGc	1.98	0.09	0	probably_damaging	0.98	neutral	0.34	neutral	2.6	neutral	-0.59	neutral	-0.1	neutral_impact	0.34	0.73	neutral	0.56	neutral	1.37	12.64	neutral	0.22	0.45	0.08	neutral	0.23	neutral	0.45	neutral	0.39	neutral	2	0.98	deleterious	0.18	neutral	-2	neutral	0.63	deleterious	-2.51	low_impact	0.03	medium_impact	-0.88	medium_impact	0.16	0.8	22.61	51.84	0.47	N	0.49	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9551	9551	C	G	MI.7366	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	345	115	H	Q	caC/caG	0.36	0.02	0	probably_damaging	0.99	neutral	0.29	neutral	2.61	neutral	0.12	neutral	0.75	neutral_impact	-1.51	0.77	neutral	0.84	neutral	1.71	14.47	neutral	0.32	0.5	0.07	neutral	0.08	neutral	0.32	neutral	0.25	neutral	5	0.99	deleterious	0.15	neutral	-2	neutral	0.60	deleterious	-2.81	low_impact	-0.03	medium_impact	-2.54	low_impact	0.25	0.8	22.61	51.84	0.42	N	0.50	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9551	9551	C	A	MI.7367	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	345	115	H	Q	caC/caA	0.36	0.02	0	probably_damaging	0.99	neutral	0.29	neutral	2.61	neutral	0.12	neutral	0.75	neutral_impact	-1.51	0.77	neutral	0.84	neutral	1.98	16.10	deleterious	0.32	0.5	0.07	neutral	0.08	neutral	0.32	neutral	0.25	neutral	5	0.99	deleterious	0.15	neutral	-2	neutral	0.60	deleterious	-2.81	low_impact	-0.03	medium_impact	-2.54	low_impact	0.25	0.8	22.61	51.84	0.42	N	0.50	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9552	9552	T	C	MI.7368	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	346	116	W	R	Tgg/Cgg	-0.8	0	0	probably_damaging	1	neutral	0.53	neutral	1.08	deleterious	-6.27	deleterious	-13.29	high_impact	3.94	0.67	neutral	0.03	damaging	3.62	23.20	deleterious	0.07	0.35	0.58	disease	0.86	disease	0.84	disease	0.75	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.22	medium_impact	2.35	high_impact	0.07	0.8	73.18	11.82	0.36	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9552	9552	T	G	MI.7369	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	346	116	W	G	Tgg/Ggg	-0.8	0	0	probably_damaging	0.99	neutral	0.41	neutral	1.08	deleterious	-6.23	deleterious	-12.34	high_impact	3.94	0.61	neutral	0.02	damaging	3.91	23.50	deleterious	0.07	0.35	0.65	disease	0.71	disease	0.83	disease	0.72	disease	4	0.99	deleterious	0.21	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	0.1	medium_impact	2.35	high_impact	0.10	0.8	73.18	11.82	0.34	N	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8873	8873	G	C	MI.737	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	347	116	G	A	gGc/gCc	9.15	1	0	benign	0.31	neutral	0.06	neutral	3.91	deleterious	-3.25	deleterious	-5.5	medium_impact	2.86	0.57	damaging	0.36	neutral	1.32	12.38	neutral	0.34	0.65	0.74	disease	0.82	disease	0.7	disease	0.64	disease	3	0.93	neutral	0.38	neutral	-3	neutral	0.63	deleterious	-0.43	medium_impact	-0.38	medium_impact	1.35	medium_impact	0.81	0.9	49.56	8.7	0.52	P	0.79	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9553	9553	G	C	MI.7370	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	347	116	W	S	tGg/tCg	7.53	1	0	probably_damaging	1	neutral	0.74	neutral	1.08	deleterious	-6.14	deleterious	-13.28	high_impact	4.39	0.65	neutral	0.02	damaging	4.03	23.70	deleterious	0.1	0.4	0.54	disease	0.87	disease	0.81	disease	0.74	disease	5	1	deleterious	0.37	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	0.45	medium_impact	2.75	high_impact	0.11	0.8	73.18	11.82	0.47	N	0.97	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9553	9553	G	T	MI.7371	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	347	116	W	L	tGg/tTg	7.53	1	0	probably_damaging	0.99	neutral	0.33	neutral	1.12	deleterious	-4.94	deleterious	-12.34	high_impact	3.64	0.6	damaging	0.02	damaging	4.24	23.90	deleterious	0.12	0.4	0.21	neutral	0.76	disease	0.82	disease	0.71	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.73	deleterious	-2.81	low_impact	0.02	medium_impact	2.08	high_impact	0.13	0.8	73.18	11.82	0.47	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9554	9554	G	T	MI.7372	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	348	116	W	C	tgG/tgT	7.53	1	0.02	probably_damaging	1	neutral	0.07	neutral	1.06	deleterious	-7.73	deleterious	-12.35	high_impact	4.39	0.66	neutral	0.02	damaging	4.17	23.80	deleterious	0.07	0.35	0.77	disease	0.86	disease	0.84	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.45	medium_impact	2.75	high_impact	0.10	0.8	73.18	11.82	0.47	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9554	9554	G	C	MI.7373	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	348	116	W	C	tgG/tgC	7.53	1	0.02	probably_damaging	1	neutral	0.07	neutral	1.06	deleterious	-7.73	deleterious	-12.35	high_impact	4.39	0.66	neutral	0.02	damaging	4.00	23.60	deleterious	0.07	0.35	0.77	disease	0.86	disease	0.84	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.45	medium_impact	2.75	high_impact	0.10	0.8	73.18	11.82	0.47	N	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9555	9555	C	T	MI.7374	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	349	117	P	S	Ccc/Tcc	2.67	1	0	probably_damaging	1	neutral	0.42	neutral	1.95	neutral	-1.85	deleterious	-7.58	medium_impact	3.48	0.65	neutral	0.01	damaging	3.93	23.50	deleterious	0.36	0.5	0.18	neutral	0.6	disease	0.65	disease	0.54	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	0.11	medium_impact	1.94	medium_impact	0.03	0.8	73.56	11.79	0.37	N	0.79	polymorphism	1	0.20	rs28754412	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9555	9555	C	G	MI.7375	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	349	117	P	A	Ccc/Gcc	2.67	1	0	probably_damaging	0.99	neutral	0.51	neutral	1.92	neutral	-2.23	deleterious	-7.58	medium_impact	3.48	0.64	neutral	0.03	damaging	3.04	22.40	deleterious	0.3	0.45	0.19	neutral	0.49	neutral	0.71	disease	0.58	disease	2	0.99	deleterious	0.26	neutral	1	deleterious	0.69	deleterious	-2.81	low_impact	0.2	medium_impact	1.94	medium_impact	0.33	0.8	73.56	11.79	0.37	N	0.70	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9555	9555	C	A	MI.7376	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	349	117	P	T	Ccc/Acc	2.67	1	0	probably_damaging	1	neutral	0.41	neutral	1.87	neutral	-2.95	deleterious	-7.58	high_impact	3.53	0.64	neutral	0.01	damaging	3.67	23.20	deleterious	0.33	0.5	0.24	neutral	0.7	disease	0.63	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.72	deleterious	-3.78	low_impact	0.1	medium_impact	1.98	medium_impact	0.34	0.8	73.56	11.79	0.31	N	0.93	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9556	9556	C	G	MI.7377	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	350	117	P	R	cCc/cGc	4.52	1	0	probably_damaging	1	neutral	0.36	neutral	1.83	deleterious	-3.78	deleterious	-8.54	high_impact	4.13	0.76	neutral	0.01	damaging	3.56	23.10	deleterious	0.17	0.45	0.3	neutral	0.73	disease	0.75	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	0.05	medium_impact	2.52	high_impact	0.21	0.8	73.56	11.79	0.46	N	0.93	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9556	9556	C	T	MI.7378	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	350	117	P	L	cCc/cTc	4.52	1	0	probably_damaging	1	neutral	0.67	neutral	1.83	deleterious	-3.84	deleterious	-9.49	medium_impact	3	0.63	neutral	0.01	damaging	4.42	24.20	deleterious	0.18	0.45	0.23	neutral	0.64	disease	0.69	disease	0.67	disease	3	1	deleterious	0.34	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	0.37	medium_impact	1.51	medium_impact	0.44	0.8	73.56	11.79	0.35	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9556	9556	C	A	MI.7379	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	350	117	P	H	cCc/cAc	4.52	1	0	probably_damaging	1	neutral	0.54	neutral	1.81	deleterious	-4.9	deleterious	-8.54	high_impact	3.98	0.62	neutral	0.01	damaging	3.97	23.60	deleterious	0.19	0.45	0.44	neutral	0.71	disease	0.76	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.23	medium_impact	2.38	high_impact	0.17	0.8	73.56	11.79	0.46	N	0.88	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8873	8873	G	A	MI.738	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	347	116	G	D	gGc/gAc	9.15	1	0	possibly_damaging	0.68	deleterious	0	neutral	3.85	deleterious	-4.5	deleterious	-6.53	high_impact	4.51	0.54	damaging	0.27	damaging	3.61	23.20	deleterious	0.19	0.65	0.97	disease	0.94	disease	0.81	disease	0.69	disease	4	1	deleterious	0.16	neutral	5	deleterious	0.85	deleterious	-1.07	low_impact	-1.4	low_impact	2.77	high_impact	0.50	0.9	49.56	8.7	0.55	P	1.00	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9558	9558	C	A	MI.7380	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	352	118	P	T	Cca/Aca	-20	0	0	probably_damaging	1	neutral	0.49	neutral	1.02	deleterious	-5.67	deleterious	-7.68	high_impact	3.6	0.59	damaging	0.37	neutral	3.72	23.30	deleterious	0.35	0.5	0.54	disease	0.73	disease	0.72	disease	0.68	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	0.18	medium_impact	2.04	high_impact	0.46	0.8	73.56	11.66	0.27	N	0.93	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9558	9558	C	G	MI.7381	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	352	118	P	A	Cca/Gca	-20	0	0	probably_damaging	0.99	neutral	0.49	neutral	1.05	deleterious	-4.98	deleterious	-7.68	medium_impact	3.31	0.58	damaging	0.49	neutral	3.08	22.50	deleterious	0.35	0.5	0.45	neutral	0.52	disease	0.72	disease	0.59	disease	2	0.99	deleterious	0.25	neutral	1	deleterious	0.75	deleterious	-2.81	low_impact	0.18	medium_impact	1.78	medium_impact	0.53	0.8	73.56	11.66	0.34	N	0.70	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9558	9558	C	T	MI.7382	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	352	118	P	S	Cca/Tca	-20	0	0	probably_damaging	1	neutral	0.53	neutral	1.04	deleterious	-5.25	deleterious	-7.68	medium_impact	3.1	0.65	neutral	0.44	neutral	3.92	23.50	deleterious	0.36	0.5	0.46	neutral	0.64	disease	0.69	disease	0.55	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.22	medium_impact	1.6	medium_impact	0.10	0.8	73.56	11.66	0.3	N	0.79	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9559	9559	C	G	MI.7383	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	353	118	P	R	cCa/cGa	7.3	1	0	probably_damaging	1	neutral	0.33	neutral	1.01	deleterious	-6.18	deleterious	-8.64	high_impact	4.34	0.53	damaging	0.33	neutral	3.57	23.20	deleterious	0.16	0.45	0.62	disease	0.78	disease	0.79	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.02	medium_impact	2.71	high_impact	0.17	0.8	73.56	11.66	0.56	P	0.93	polymorphism	1	0.26	rs2856984	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9559	9559	C	T	MI.7384	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	353	118	P	L	cCa/cTa	7.3	1	0	probably_damaging	1	neutral	0.68	neutral	1.01	deleterious	-6	deleterious	-9.61	high_impact	3.54	0.54	damaging	0.45	neutral	4.36	24.10	deleterious	0.26	0.45	0.65	disease	0.69	disease	0.7	disease	0.57	disease	1	1	deleterious	0.34	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.38	medium_impact	1.99	medium_impact	0.45	0.8	73.56	11.66	0.52	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9559	9559	C	A	MI.7385	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	353	118	P	Q	cCa/cAa	7.3	1	0	probably_damaging	1	neutral	0.28	neutral	1.01	deleterious	-6.42	deleterious	-7.69	high_impact	3.6	0.61	neutral	0.41	neutral	4.05	23.70	deleterious	0.24	0.45	0.57	disease	0.75	disease	0.75	disease	0.6	disease	2	1	deleterious	0.14	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	-0.04	medium_impact	2.04	high_impact	0.19	0.8	73.56	11.66	0.52	N	0.86	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9561	9561	A	C	MI.7386	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	355	119	T	P	Aca/Cca	-7.51	0	0	probably_damaging	0.99	neutral	0.26	neutral	2.62	neutral	-1.41	deleterious	-2.64	low_impact	1.45	0.59	damaging	0.06	damaging	3.50	23.10	deleterious	0.16	0.45	0.36	neutral	0.48	neutral	0.24	neutral	0.41	neutral	2	0.99	deleterious	0.14	neutral	-2	neutral	0.69	deleterious	-2.81	low_impact	-0.07	medium_impact	0.12	medium_impact	0.17	0.8	48.66	11.95	0.3	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9561	9561	A	T	MI.7387	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	355	119	T	S	Aca/Tca	-7.51	0	0	probably_damaging	0.92	neutral	0.4	neutral	2.55	neutral	-0.09	neutral	-0.72	low_impact	1	0.68	neutral	0.42	neutral	2.23	17.69	deleterious	0.42	0.55	0.16	neutral	0.12	neutral	0.15	neutral	0.3	neutral	4	0.92	neutral	0.24	neutral	-2	neutral	0.59	deleterious	-1.9	low_impact	0.09	medium_impact	-0.29	medium_impact	0.15	0.8	48.66	11.95	0.45	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9561	9561	A	G	MI.7388	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	355	119	T	A	Aca/Gca	-7.51	0	0	probably_damaging	0.92	neutral	0.51	neutral	2.58	neutral	0.41	neutral	-1.45	neutral_impact	0.44	0.71	neutral	0.55	neutral	2.16	17.23	deleterious	0.32	0.5	0.13	neutral	0.09	neutral	0.25	neutral	0.29	neutral	4	0.91	neutral	0.3	neutral	-2	neutral	0.57	deleterious	-1.9	low_impact	0.2	medium_impact	-0.79	medium_impact	0.18	0.8	48.66	11.95	0.28	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9562	9562	C	A	MI.7389	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	356	119	T	K	aCa/aAa	0.82	0	0	probably_damaging	0.98	neutral	0.3	neutral	2.58	neutral	0.3	neutral	-1.01	neutral_impact	0.54	0.65	neutral	0.21	damaging	3.15	22.60	deleterious	0.14	0.4	0.14	neutral	0.16	neutral	0.17	neutral	0.27	neutral	5	0.98	deleterious	0.16	neutral	-2	neutral	0.63	deleterious	-2.51	low_impact	-0.02	medium_impact	-0.7	medium_impact	0.24	0.8	48.66	11.95	0.47	N	0.92	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8875	8875	T	C	MI.739	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	349	117	F	L	Ttt/Ctt	-20	0	0	benign	0	neutral	0.97	neutral	4.5	neutral	-0.84	neutral	-1.16	neutral_impact	-0.11	0.95	neutral	0.89	neutral	-0.53	0.19	neutral	0.39	0.65	0.4	neutral	0.3	neutral	0.27	neutral	0.47	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.14	medium_impact	-1.19	low_impact	0.76	0.9	22.57	16.62	0.28	N	0.07	polymorphism	1	0.02	rs201123510	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9562	9562	C	T	MI.7390	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	356	119	T	M	aCa/aTa	0.82	0	0	probably_damaging	1	neutral	0.25	neutral	2.53	neutral	-2.15	neutral	-1.83	low_impact	1.33	0.68	neutral	0.35	neutral	2.81	21.40	deleterious	0.23	0.45	0.25	neutral	0.12	neutral	0.17	neutral	0.31	neutral	4	1	deleterious	0.13	neutral	-2	neutral	0.62	deleterious	-3.78	low_impact	-0.08	medium_impact	0.01	medium_impact	0.18	0.8	48.66	11.95	0.5	N	0.95	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9564	9564	G	T	MI.7391	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	358	120	G	C	Ggc/Tgc	-2.65	0	0	probably_damaging	1	neutral	0.18	neutral	1.64	deleterious	-5.82	deleterious	-8.23	high_impact	4.21	0.6	neutral	0.02	damaging	4.14	23.80	deleterious	0.09	0.35	0.78	disease	0.89	disease	0.63	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.18	medium_impact	2.59	high_impact	0.03	0.8	73.95	11.76	0.33	N	0.98	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9564	9564	G	A	MI.7392	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	358	120	G	S	Ggc/Agc	-2.65	0	0	probably_damaging	1	neutral	0.55	neutral	1.73	deleterious	-3.08	deleterious	-5.28	medium_impact	3.01	0.48	damaging	0.05	damaging	4.13	23.80	deleterious	0.18	0.45	0.43	neutral	0.74	disease	0.5	neutral	0.43	neutral	1	1	deleterious	0.28	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	0.24	medium_impact	1.52	medium_impact	0.43	0.8	73.95	11.76	0.27	N	0.85	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9564	9564	G	C	MI.7393	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	358	120	G	R	Ggc/Cgc	-2.65	0	0	probably_damaging	1	neutral	0.45	neutral	1.67	deleterious	-4.38	deleterious	-7.24	high_impact	4.21	0.6	damaging	0.02	damaging	3.95	23.60	deleterious	0.11	0.4	0.54	disease	0.87	disease	0.7	disease	0.73	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	0.14	medium_impact	2.59	high_impact	0.54	0.8	73.95	11.76	0.31	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9565	9565	G	T	MI.7394	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	359	120	G	V	gGc/gTc	7.3	1	0	probably_damaging	1	neutral	0.57	neutral	1.67	deleterious	-4.34	deleterious	-8.23	high_impact	4	0.57	damaging	0.01	damaging	3.78	23.40	deleterious	0.1	0.4	0.53	disease	0.87	disease	0.65	disease	0.71	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.26	medium_impact	2.4	high_impact	0.05	0.8	73.95	11.76	0.45	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9565	9565	G	C	MI.7395	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	359	120	G	A	gGc/gCc	7.3	1	0	probably_damaging	0.99	neutral	0.65	neutral	1.74	neutral	-2.87	deleterious	-5.43	medium_impact	2.89	0.64	neutral	0.03	damaging	3.13	22.60	deleterious	0.23	0.45	0.4	neutral	0.73	disease	0.49	neutral	0.47	neutral	1	0.98	deleterious	0.33	neutral	1	deleterious	0.80	deleterious	-2.81	low_impact	0.35	medium_impact	1.41	medium_impact	0.16	0.8	73.95	11.76	0.36	N	0.30	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9565	9565	G	A	MI.7396	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	359	120	G	D	gGc/gAc	7.3	1	0	probably_damaging	1	neutral	0.32	neutral	1.7	deleterious	-3.59	deleterious	-6.02	medium_impact	3.4	0.56	damaging	0.02	damaging	3.84	23.40	deleterious	0.12	0.4	0.53	disease	0.85	disease	0.5	neutral	0.6	disease	2	1	deleterious	0.16	neutral	1	deleterious	0.83	deleterious	-3.78	low_impact	0.01	medium_impact	1.86	medium_impact	0.06	0.8	73.95	11.76	0.4	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9567	9567	A	G	MI.7397	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	361	121	I	V	Atc/Gtc	-9.82	0	0	possibly_damaging	0.87	neutral	0.35	neutral	1.98	neutral	-1.37	neutral	-0.67	low_impact	1.56	0.68	neutral	0.81	neutral	1.92	15.74	deleterious	0.54	0.6	0.17	neutral	0.2	neutral	0.34	neutral	0.32	neutral	4	0.88	neutral	0.24	neutral	-3	neutral	0.46	deleterious	-1.67	low_impact	0.04	medium_impact	0.22	medium_impact	0.20	0.8	76.63	10.68	0.46	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9567	9567	A	T	MI.7398	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	361	121	I	F	Atc/Ttc	-9.82	0	0	probably_damaging	0.99	neutral	0.15	neutral	1.76	deleterious	-3.93	deleterious	-3.83	high_impact	3.62	0.6	damaging	0.05	damaging	3.85	23.40	deleterious	0.17	0.45	0.38	neutral	0.66	disease	0.68	disease	0.56	disease	1	1	deleterious	0.08	neutral	2	deleterious	0.74	deleterious	-2.81	low_impact	-0.24	medium_impact	2.06	high_impact	0.28	0.8	76.63	10.68	0.26	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9567	9567	A	C	MI.7399	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	361	121	I	L	Atc/Ctc	-9.82	0	0	probably_damaging	0.95	neutral	0.43	neutral	1.96	neutral	-1.48	neutral	-1.88	medium_impact	2.56	0.66	neutral	0.13	damaging	3.82	23.40	deleterious	0.27	0.45	0.2	neutral	0.48	neutral	0.49	neutral	0.37	neutral	3	0.95	neutral	0.24	neutral	1	deleterious	0.51	deleterious	-2.11	low_impact	0.12	medium_impact	1.11	medium_impact	0.37	0.8	76.63	10.68	0.29	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8558	8558	C	G	MI.74	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	32	11	A	G	gCc/gGc	1.05	0.01	0	benign	0.19	neutral	0.11	neutral	4.62	neutral	-1.42	neutral	-1.8	neutral_impact	0	0.82	neutral	0.56	neutral	3.33	22.90	deleterious	0.36	0.65	0.51	disease	0.58	disease	0.44	neutral	0.48	neutral	0	0.87	neutral	0.46	neutral	-6	neutral	0.39	neutral	-0.16	medium_impact	-0.22	medium_impact	-1.1	low_impact	0.58	0.9	23.45	19.76	0.39	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8875	8875	T	A	MI.740	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	349	117	F	I	Ttt/Att	-20	0	0	benign	0.07	neutral	0.74	neutral	4.54	neutral	-0.12	neutral	-1.96	low_impact	1.39	0.85	neutral	0.57	neutral	2.50	19.49	deleterious	0.26	0.65	0.43	neutral	0.69	disease	0.36	neutral	0.5	neutral	0	0.17	neutral	0.84	deleterious	-6	neutral	0.24	neutral	0.31	medium_impact	0.55	medium_impact	0.09	medium_impact	0.60	0.9	22.57	16.62	0.24	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9568	9568	T	C	MI.7400	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	362	121	I	T	aTc/aCc	3.83	0.99	0	probably_damaging	1	neutral	0.62	neutral	1.76	deleterious	-3.99	deleterious	-4.48	medium_impact	2.5	0.65	neutral	0.05	damaging	3.42	23.00	deleterious	0.14	0.4	0.31	neutral	0.73	disease	0.63	disease	0.65	disease	3	1	deleterious	0.31	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.31	medium_impact	1.06	medium_impact	0.17	0.8	76.63	10.68	0.33	N	0.91	polymorphism	1	0.11	.	Uncertain_significance	not_specified	433705	MedGen:CN169374	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9568	9568	T	G	MI.7401	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	362	121	I	S	aTc/aGc	3.83	0.99	0	probably_damaging	1	neutral	0.78	neutral	1.74	deleterious	-4.63	deleterious	-5.59	medium_impact	3.23	0.68	neutral	0.05	damaging	4.31	24.00	deleterious	0.05	0.35	0.3	neutral	0.79	disease	0.64	disease	0.66	disease	3	1	deleterious	0.39	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	0.51	medium_impact	1.71	medium_impact	0.10	0.8	76.63	10.68	0.33	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9568	9568	T	A	MI.7402	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	362	121	I	N	aTc/aAc	3.83	0.99	0	probably_damaging	1	neutral	0.55	neutral	1.72	deleterious	-5.62	deleterious	-6.57	high_impact	3.88	0.61	neutral	0.05	damaging	4.45	24.20	deleterious	0.11	0.4	0.52	disease	0.8	disease	0.66	disease	0.67	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	0.24	medium_impact	2.3	high_impact	0.08	0.8	76.63	10.68	0.42	N	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9569	9569	C	A	MI.7403	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	363	121	I	M	atC/atA	7.53	1	0	probably_damaging	1	neutral	0.17	neutral	1.81	neutral	-2.9	deleterious	-2.71	medium_impact	3.04	0.66	neutral	0.05	damaging	3.76	23.30	deleterious	0.32	0.5	0.32	neutral	0.52	disease	0.53	disease	0.48	neutral	0	1	deleterious	0.09	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	-0.2	medium_impact	1.54	medium_impact	0.32	0.8	76.63	10.68	0.49	N	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9569	9569	C	G	MI.7404	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	363	121	I	M	atC/atG	7.53	1	0	probably_damaging	1	neutral	0.17	neutral	1.81	neutral	-2.9	deleterious	-2.71	medium_impact	3.04	0.66	neutral	0.05	damaging	3.31	22.90	deleterious	0.32	0.5	0.32	neutral	0.52	disease	0.53	disease	0.48	neutral	0	1	deleterious	0.09	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	-0.2	medium_impact	1.54	medium_impact	0.32	0.8	76.63	10.68	0.49	N	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9570	9570	A	T	MI.7405	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	364	122	T	S	Acc/Tcc	-3.34	0	0	benign	0.12	neutral	0.78	neutral	2.32	neutral	0	neutral	-0.53	low_impact	1.25	0.79	neutral	0.8	neutral	-0.22	0.99	neutral	0.62	0.65	0.11	neutral	0.1	neutral	0.14	neutral	0.31	neutral	4	0.11	neutral	0.83	deleterious	-6	neutral	0.12	neutral	-0.03	medium_impact	0.51	medium_impact	-0.06	medium_impact	0.59	0.8	22.61	31.69	0.4	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9570	9570	A	G	MI.7406	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	364	122	T	A	Acc/Gcc	-3.34	0	0	benign	0.06	neutral	0.79	neutral	2.34	neutral	0.19	neutral	-1.36	low_impact	1.5	0.73	neutral	0.39	neutral	0.08	3.36	deleterious	0.28	0.45	0.17	neutral	0.15	neutral	0.27	neutral	0.28	neutral	5	0.12	neutral	0.87	deleterious	-6	neutral	0.10	neutral	0.29	medium_impact	0.52	medium_impact	0.16	medium_impact	0.18	0.8	22.61	31.69	0.33	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9570	9570	A	C	MI.7407	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	364	122	T	P	Acc/Ccc	-3.34	0	0	possibly_damaging	0.55	neutral	0.37	neutral	2.24	neutral	-1.79	neutral	-2.25	low_impact	1.51	0.63	neutral	0.17	damaging	2.08	16.70	deleterious	0.1	0.4	0.37	neutral	0.47	neutral	0.3	neutral	0.5	disease	0	0.63	neutral	0.41	neutral	-3	neutral	0.44	deleterious	-0.95	medium_impact	0.06	medium_impact	0.17	medium_impact	0.31	0.8	22.61	31.69	0.3	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9571	9571	C	T	MI.7408	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	365	122	T	I	aCc/aTc	0.36	0	0	benign	0	neutral	0.34	neutral	2.26	neutral	-1.33	neutral	-1.66	low_impact	1.51	0.76	neutral	0.55	neutral	0.26	5.28	deleterious	0.27	0.45	0.2	neutral	0.15	neutral	0.23	neutral	0.29	neutral	4	0.66	neutral	0.67	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	0.03	medium_impact	0.17	medium_impact	0.23	0.8	22.61	31.69	0.46	N	0.03	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9571	9571	C	A	MI.7409	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	365	122	T	N	aCc/aAc	0.36	0	0	benign	0.43	neutral	0.56	neutral	2.3	neutral	-0.32	neutral	-0.81	low_impact	0.95	0.77	neutral	0.95	neutral	1.86	15.32	deleterious	0.49	0.55	0.22	neutral	0.19	neutral	0.16	neutral	0.36	neutral	3	0.41	neutral	0.57	deleterious	-6	neutral	0.38	neutral	-0.75	medium_impact	0.25	medium_impact	-0.33	medium_impact	0.25	0.8	22.61	31.69	0.41	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8875	8875	T	G	MI.741	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	349	117	F	V	Ttt/Gtt	-20	0	0	benign	0.11	neutral	0.17	neutral	4.44	neutral	-1.15	deleterious	-2.75	low_impact	1.84	0.85	neutral	0.57	neutral	1.19	11.68	neutral	0.3	0.65	0.67	disease	0.75	disease	0.4	neutral	0.56	disease	1	0.81	neutral	0.53	deleterious	-6	neutral	0.29	neutral	0.11	medium_impact	-0.1	medium_impact	0.48	medium_impact	0.54	0.9	22.57	16.62	0.3	N	0.86	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9571	9571	C	G	MI.7410	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	365	122	T	S	aCc/aGc	0.36	0	0	benign	0.12	neutral	0.78	neutral	2.32	neutral	0	neutral	-0.53	low_impact	1.25	0.79	neutral	0.8	neutral	0.02	2.78	deleterious	0.62	0.65	0.11	neutral	0.1	neutral	0.14	neutral	0.31	neutral	4	0.11	neutral	0.83	deleterious	-6	neutral	0.12	neutral	-0.03	medium_impact	0.51	medium_impact	-0.06	medium_impact	0.59	0.8	22.61	31.69	0.37	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9573	9573	C	A	MI.7411	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	367	123	P	T	Ccg/Acg	-4.5	0	0	probably_damaging	0.99	neutral	0.4	neutral	2.54	neutral	-0.33	deleterious	-4.9	low_impact	1.14	0.66	neutral	0.28	neutral	2.46	19.18	deleterious	0.46	0.55	0.18	neutral	0.31	neutral	0.23	neutral	0.43	neutral	1	0.99	deleterious	0.21	neutral	-2	neutral	0.65	deleterious	-2.81	low_impact	0.09	medium_impact	-0.16	medium_impact	0.49	0.8	73.18	11.49	0.33	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9573	9573	C	T	MI.7412	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	367	123	P	S	Ccg/Tcg	-4.5	0	0	probably_damaging	0.99	neutral	0.4	neutral	2.51	neutral	-0.41	deleterious	-5.35	medium_impact	2.1	0.53	damaging	0.08	damaging	3.82	23.40	deleterious	0.47	0.55	0.15	neutral	0.46	neutral	0.29	neutral	0.4	neutral	2	0.99	deleterious	0.21	neutral	1	deleterious	0.67	deleterious	-2.81	low_impact	0.09	medium_impact	0.7	medium_impact	0.06	0.8	73.18	11.49	0.26	N	0.79	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9573	9573	C	G	MI.7413	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	367	123	P	A	Ccg/Gcg	-4.5	0	0	probably_damaging	0.94	neutral	0.51	neutral	2.58	neutral	-0.06	deleterious	-5.49	low_impact	1.12	0.65	neutral	0.29	neutral	1.99	16.18	deleterious	0.47	0.55	0.15	neutral	0.26	neutral	0.28	neutral	0.43	neutral	2	0.94	neutral	0.29	neutral	-2	neutral	0.64	deleterious	-2.03	low_impact	0.2	medium_impact	-0.18	medium_impact	0.46	0.8	73.18	11.49	0.28	N	0.70	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9574	9574	C	T	MI.7414	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	368	123	P	L	cCg/cTg	3.14	0.99	0	probably_damaging	1	neutral	0.66	neutral	2.56	neutral	-1.69	deleterious	-7.41	medium_impact	2.32	0.5	damaging	0.02	damaging	4.36	24.10	deleterious	0.25	0.45	0.2	neutral	0.58	disease	0.44	neutral	0.36	neutral	3	1	deleterious	0.33	neutral	1	deleterious	0.68	deleterious	-3.78	low_impact	0.36	medium_impact	0.9	medium_impact	0.41	0.8	73.18	11.49	0.3	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9574	9574	C	G	MI.7415	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	368	123	P	R	cCg/cGg	3.14	0.99	0	probably_damaging	1	neutral	0.35	neutral	2.49	neutral	-1.02	deleterious	-6.65	high_impact	3.54	0.48	damaging	0.02	damaging	3.61	23.20	deleterious	0.2	0.45	0.21	neutral	0.68	disease	0.65	disease	0.65	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.72	deleterious	-3.78	low_impact	0.04	medium_impact	1.99	medium_impact	0.26	0.8	73.18	11.49	0.37	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9574	9574	C	A	MI.7416	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	368	123	P	Q	cCg/cAg	3.14	0.99	0	probably_damaging	1	neutral	0.3	neutral	2.5	neutral	-0.69	deleterious	-5.87	medium_impact	3.08	0.5	damaging	0.02	damaging	4.09	23.70	deleterious	0.23	0.45	0.2	neutral	0.6	disease	0.59	disease	0.64	disease	3	1	deleterious	0.15	neutral	1	deleterious	0.67	deleterious	-3.78	low_impact	-0.02	medium_impact	1.58	medium_impact	0.22	0.8	73.18	11.49	0.36	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9576	9576	C	G	MI.7417	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	370	124	L	V	Cta/Gta	-12.83	0	0	probably_damaging	0.92	neutral	0.51	neutral	2.21	neutral	-0.62	neutral	-1.61	low_impact	1.68	0.49	damaging	0.01	damaging	3.44	23.00	deleterious	0.37	0.5	0.14	neutral	0.3	neutral	0.44	neutral	0.43	neutral	1	0.91	neutral	0.3	neutral	-2	neutral	0.61	deleterious	-1.9	low_impact	0.2	medium_impact	0.32	medium_impact	0.27	0.8	73.18	11.39	0.28	N	0.81	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9576	9576	C	A	MI.7418	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	370	124	L	M	Cta/Ata	-12.83	0	0	probably_damaging	1	neutral	0.23	neutral	2.04	neutral	-2.5	neutral	-0.78	low_impact	1.4	0.56	damaging	0.06	damaging	3.74	23.30	deleterious	0.29	0.45	0.26	neutral	0.29	neutral	0.26	neutral	0.44	neutral	1	1	deleterious	0.12	neutral	-2	neutral	0.68	deleterious	-3.78	low_impact	-0.11	medium_impact	0.07	medium_impact	0.46	0.8	73.18	11.39	0.35	N	0.85	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9577	9577	T	C	MI.7419	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	371	124	L	P	cTa/cCa	-0.8	0	0	probably_damaging	1	neutral	0.25	neutral	2.02	deleterious	-3.14	deleterious	-5.22	medium_impact	2.56	0.48	damaging	0.02	damaging	3.91	23.50	deleterious	0.05	0.35	0.45	neutral	0.77	disease	0.59	disease	0.62	disease	2	1	deleterious	0.13	neutral	1	deleterious	0.81	deleterious	-3.78	low_impact	-0.08	medium_impact	1.11	medium_impact	0.13	0.8	73.18	11.39	0.27	N	0.99	polymorphism	1	0.09	rs386829086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8876	8876	T	C	MI.742	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	350	117	F	S	tTt/tCt	0.36	0.1	0	benign	0.34	neutral	0.18	neutral	4.26	neutral	-2.85	deleterious	-4.51	medium_impact	2.41	0.82	neutral	0.52	neutral	3.74	23.30	deleterious	0.22	0.65	0.86	disease	0.73	disease	0.59	disease	0.74	disease	5	0.79	neutral	0.42	neutral	-3	neutral	0.54	deleterious	-0.48	medium_impact	-0.08	medium_impact	0.97	medium_impact	0.63	0.9	22.57	16.62	0.35	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9577	9577	T	A	MI.7420	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	371	124	L	Q	cTa/cAa	-0.8	0	0	probably_damaging	1	neutral	0.32	neutral	2.01	deleterious	-3.58	deleterious	-4.29	high_impact	4.08	0.56	damaging	0.02	damaging	4.06	23.70	deleterious	0.07	0.35	0.25	neutral	0.68	disease	0.6	disease	0.68	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.72	deleterious	-3.78	low_impact	0.01	medium_impact	2.47	high_impact	0.11	0.8	73.18	11.39	0.32	N	0.97	polymorphism	1	0.12	rs386829086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9577	9577	T	G	MI.7421	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	371	124	L	R	cTa/cGa	-0.8	0	0	probably_damaging	1	neutral	0.37	neutral	2.01	deleterious	-3.53	deleterious	-4.35	medium_impact	3.38	0.49	damaging	0.02	damaging	4.18	23.80	deleterious	0.04	0.35	0.31	neutral	0.78	disease	0.68	disease	0.7	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	0.06	medium_impact	1.85	medium_impact	0.15	0.8	73.18	11.39	0.29	N	0.99	polymorphism	1	0.16	rs386829086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9579	9579	A	T	MI.7422	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	373	125	N	Y	Aat/Tat	-7.28	0	0	possibly_damaging	0.72	neutral	1	neutral	2.01	deleterious	-4.34	deleterious	-7.24	medium_impact	3	0.64	neutral	0.38	neutral	3.69	23.30	deleterious	0.2	0.45	0.3	neutral	0.67	disease	0.66	disease	0.66	disease	3	0.72	neutral	0.64	deleterious	0	NA	0.64	deleterious	-1.27	low_impact	1.9	high_impact	1.51	medium_impact	0.12	0.8	77.78	9.98	0.22	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9579	9579	A	G	MI.7423	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	373	125	N	D	Aat/Gat	-7.28	0	0	benign	0	neutral	0.22	neutral	2.19	neutral	-0.79	deleterious	-3.7	low_impact	0.88	0.71	neutral	0.73	neutral	0.10	3.56	deleterious	0.53	0.6	0.13	neutral	0.14	neutral	0.36	neutral	0.26	neutral	5	0.78	neutral	0.61	deleterious	-6	neutral	0.11	neutral	2.05	high_impact	-0.12	medium_impact	-0.39	medium_impact	0.22	0.8	77.78	9.98	0.47	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9579	9579	A	C	MI.7424	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	373	125	N	H	Aat/Cat	-7.28	0	0	possibly_damaging	0.61	neutral	0.54	neutral	2.02	deleterious	-3.43	deleterious	-4.47	medium_impact	3	0.67	neutral	0.38	neutral	3.05	22.40	deleterious	0.4	0.5	0.32	neutral	0.63	disease	0.6	disease	0.64	disease	3	0.57	neutral	0.47	neutral	0	NA	0.58	deleterious	-1.06	low_impact	0.23	medium_impact	1.51	medium_impact	0.13	0.8	77.78	9.98	0.26	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9580	9580	A	T	MI.7425	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	374	125	N	I	aAt/aTt	1.29	0.73	0	possibly_damaging	0.63	neutral	0.39	neutral	2.01	deleterious	-4	deleterious	-8.09	high_impact	3.6	0.66	neutral	0.55	neutral	3.73	23.30	deleterious	0.16	0.45	0.35	neutral	0.69	disease	0.61	disease	0.64	disease	3	0.67	neutral	0.38	neutral	1	deleterious	0.57	deleterious	-1.09	low_impact	0.08	medium_impact	2.04	high_impact	0.09	0.8	77.78	9.98	0.4	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9580	9580	A	C	MI.7426	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	374	125	N	T	aAt/aCt	1.29	0.73	0	benign	0.12	neutral	0.39	neutral	2.05	neutral	-2.49	deleterious	-5.29	medium_impact	3.11	0.64	neutral	0.54	neutral	2.94	22.00	deleterious	0.35	0.5	0.19	neutral	0.62	disease	0.61	disease	0.64	disease	3	0.55	neutral	0.64	deleterious	-3	neutral	0.23	neutral	-0.03	medium_impact	0.08	medium_impact	1.61	medium_impact	0.18	0.8	77.78	9.98	0.4	N	0.87	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9580	9580	A	G	MI.7427	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	374	125	N	S	aAt/aGt	1.29	0.73	0	benign	0.02	neutral	0.4	neutral	2.1	neutral	-1.73	deleterious	-4.32	low_impact	1.53	0.67	neutral	0.61	neutral	1.15	11.46	neutral	0.52	0.6	0.14	neutral	0.47	neutral	0.4	neutral	0.33	neutral	3	0.59	neutral	0.69	deleterious	-6	neutral	0.15	neutral	0.77	medium_impact	0.09	medium_impact	0.19	medium_impact	0.17	0.8	77.78	9.98	0.37	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9581	9581	T	G	MI.7428	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	375	125	N	K	aaT/aaG	8.69	0.98	0	benign	0.14	neutral	0.3	neutral	2.09	neutral	-1.8	deleterious	-5.31	medium_impact	2.91	0.63	neutral	0.38	neutral	3.74	23.30	deleterious	0.39	0.5	0.13	neutral	0.62	disease	0.64	disease	0.57	disease	1	0.65	neutral	0.58	deleterious	-3	neutral	0.38	neutral	-0.1	medium_impact	-0.02	medium_impact	1.43	medium_impact	0.13	0.8	77.78	9.98	0.56	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9581	9581	T	A	MI.7429	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	375	125	N	K	aaT/aaA	8.69	0.98	0	benign	0.14	neutral	0.3	neutral	2.09	neutral	-1.8	deleterious	-5.31	medium_impact	2.91	0.63	neutral	0.38	neutral	4.01	23.60	deleterious	0.39	0.5	0.13	neutral	0.62	disease	0.64	disease	0.57	disease	1	0.65	neutral	0.58	deleterious	-3	neutral	0.38	neutral	-0.1	medium_impact	-0.02	medium_impact	1.43	medium_impact	0.13	0.8	77.78	9.98	0.57	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8876	8876	T	G	MI.743	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	350	117	F	C	tTt/tGt	0.36	0.1	0	possibly_damaging	0.81	neutral	0.05	neutral	4.28	deleterious	-3.97	deleterious	-4.19	medium_impact	2.49	0.78	neutral	0.45	neutral	3.97	23.60	deleterious	0.21	0.65	0.93	disease	0.84	disease	0.61	disease	0.81	disease	6	0.97	neutral	0.12	neutral	0	NA	0.78	deleterious	-1.35	low_impact	-0.43	medium_impact	1.04	medium_impact	0.37	0.9	22.57	16.62	0.31	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9582	9582	C	T	MI.7430	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	376	126	P	S	Ccc/Tcc	-1.03	0	0	probably_damaging	1	neutral	0.94	neutral	2.02	neutral	-2.01	deleterious	-7.08	medium_impact	3.15	0.67	neutral	0.03	damaging	3.86	23.40	deleterious	0.46	0.55	0.13	neutral	0.66	disease	0.55	disease	0.61	disease	2	1	deleterious	0.47	deleterious	1	deleterious	0.71	deleterious	-3.78	low_impact	0.87	medium_impact	1.64	medium_impact	0.07	0.8	73.95	11.66	0.18	N	0.79	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9582	9582	C	G	MI.7431	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	376	126	P	A	Ccc/Gcc	-1.03	0	0	probably_damaging	0.99	neutral	0.99	neutral	2.06	neutral	-1.52	deleterious	-6.91	medium_impact	2.46	0.53	damaging	0.11	damaging	3.08	22.50	deleterious	0.36	0.5	0.15	neutral	0.35	neutral	0.34	neutral	0.38	neutral	2	0.99	deleterious	0.5	deleterious	1	deleterious	0.68	deleterious	-2.81	low_impact	1.33	medium_impact	1.02	medium_impact	0.56	0.8	73.95	11.66	0.23	N	0.70	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9582	9582	C	A	MI.7432	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	376	126	P	T	Ccc/Acc	-1.03	0	0	probably_damaging	1	neutral	0.8	neutral	2.01	neutral	-2.08	deleterious	-7.14	medium_impact	3	0.51	damaging	0.04	damaging	3.86	23.50	deleterious	0.35	0.5	0.2	neutral	0.63	disease	0.47	neutral	0.23	neutral	5	1	deleterious	0.4	neutral	1	deleterious	0.71	deleterious	-3.78	low_impact	0.54	medium_impact	1.51	medium_impact	0.51	0.8	73.95	11.66	0.21	N	0.93	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9583	9583	C	G	MI.7433	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	377	126	P	R	cCc/cGc	7.3	1	0	probably_damaging	1	neutral	0.68	neutral	1.95	deleterious	-3.3	deleterious	-8.12	high_impact	3.92	0.73	neutral	0.02	damaging	3.64	23.20	deleterious	0.17	0.45	0.21	neutral	0.74	disease	0.69	disease	0.66	disease	3	1	deleterious	0.34	neutral	2	deleterious	0.74	deleterious	-3.78	low_impact	0.38	medium_impact	2.33	high_impact	0.24	0.8	73.95	11.66	0.43	N	0.93	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9583	9583	C	A	MI.7434	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	377	126	P	H	cCc/cAc	7.3	1	0	probably_damaging	1	neutral	0.59	neutral	1.92	deleterious	-4.43	deleterious	-8.18	medium_impact	3.5	0.61	neutral	0.01	damaging	4.01	23.60	deleterious	0.19	0.45	0.33	neutral	0.73	disease	0.64	disease	0.65	disease	3	1	deleterious	0.3	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.28	medium_impact	1.95	medium_impact	0.19	0.8	73.95	11.66	0.37	N	0.88	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9583	9583	C	T	MI.7435	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	377	126	P	L	cCc/cTc	7.3	1	0	probably_damaging	1	neutral	0.9	neutral	1.96	neutral	-2.93	deleterious	-9.02	medium_impact	2.58	0.61	neutral	0.01	damaging	4.41	24.10	deleterious	0.26	0.45	0.19	neutral	0.68	disease	0.56	disease	0.62	disease	2	1	deleterious	0.45	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	0.74	medium_impact	1.13	medium_impact	0.41	0.8	73.95	11.66	0.36	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9585	9585	C	G	MI.7436	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	379	127	L	V	Cta/Gta	-5.89	0	0	benign	0.05	neutral	0.51	neutral	2.39	neutral	-0.93	neutral	-1.16	low_impact	1.72	0.61	neutral	0.08	damaging	1.71	14.49	neutral	0.34	0.5	0.15	neutral	0.27	neutral	0.58	disease	0.46	neutral	1	0.44	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.37	medium_impact	0.2	medium_impact	0.36	medium_impact	0.27	0.8	20.31	19.28	0.27	N	0.40	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9585	9585	C	A	MI.7437	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	379	127	L	M	Cta/Ata	-5.89	0	0	benign	0.05	neutral	0.22	neutral	2.33	neutral	-2.53	neutral	0.37	low_impact	1.05	0.72	neutral	0.83	neutral	0.64	8.43	deleterious	0.29	0.45	0.33	neutral	0.14	neutral	0.28	neutral	0.29	neutral	4	0.76	neutral	0.59	deleterious	-6	neutral	0.17	neutral	0.37	medium_impact	-0.12	medium_impact	-0.24	medium_impact	0.56	0.8	20.31	19.28	0.52	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9586	9586	T	G	MI.7438	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	380	127	L	R	cTa/cGa	-1.49	0	0	possibly_damaging	0.62	neutral	0.36	neutral	2.33	deleterious	-3.65	deleterious	-3.18	medium_impact	1.97	0.55	damaging	0.04	damaging	4.15	23.80	deleterious	0.03	0.35	0.27	neutral	0.7	disease	0.63	disease	0.7	disease	4	0.68	neutral	0.37	neutral	0	NA	0.64	deleterious	-1.08	low_impact	0.05	medium_impact	0.58	medium_impact	0.14	0.8	20.31	19.28	0.22	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9586	9586	T	A	MI.7439	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	380	127	L	Q	cTa/cAa	-1.49	0	0	possibly_damaging	0.62	neutral	0.3	neutral	2.31	deleterious	-3.55	deleterious	-2.94	medium_impact	2.47	0.62	neutral	0.06	damaging	4.04	23.70	deleterious	0.05	0.35	0.34	neutral	0.53	disease	0.57	disease	0.68	disease	4	0.73	neutral	0.34	neutral	0	NA	0.63	deleterious	-1.08	low_impact	-0.02	medium_impact	1.03	medium_impact	0.12	0.8	20.31	19.28	0.27	N	0.79	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8876	8876	T	A	MI.744	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	350	117	F	Y	tTt/tAt	0.36	0.1	0	benign	0.34	neutral	0.46	neutral	4.25	neutral	-2.92	neutral	-1.87	medium_impact	2.23	0.85	neutral	0.48	neutral	2.49	19.43	deleterious	0.29	0.65	0.89	disease	0.67	disease	0.57	disease	0.71	disease	4	0.46	neutral	0.56	deleterious	-3	neutral	0.52	deleterious	-0.48	medium_impact	0.25	medium_impact	0.81	medium_impact	0.68	0.9	22.57	16.62	0.29	N	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9586	9586	T	C	MI.7440	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	380	127	L	P	cTa/cCa	-1.49	0	0	possibly_damaging	0.88	neutral	0.22	neutral	2.36	deleterious	-4.07	deleterious	-4.12	low_impact	1.66	0.5	damaging	0.04	damaging	3.90	23.50	deleterious	0.04	0.35	0.49	neutral	0.74	disease	0.56	disease	0.69	disease	4	0.92	neutral	0.17	neutral	-3	neutral	0.80	deleterious	-1.71	low_impact	-0.12	medium_impact	0.31	medium_impact	0.13	0.8	20.31	19.28	0.26	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9588	9588	G	C	MI.7441	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	382	128	E	Q	Gaa/Caa	-1.26	0	0	probably_damaging	0.92	neutral	0.3	neutral	2.14	neutral	-1.43	neutral	0.2	low_impact	0.9	0.63	neutral	0.73	neutral	1.81	15.05	deleterious	0.31	0.45	0.2	neutral	0.13	neutral	0.29	neutral	0.23	neutral	5	0.94	neutral	0.19	neutral	-2	neutral	0.65	deleterious	-1.9	low_impact	-0.02	medium_impact	-0.38	medium_impact	0.43	0.8	73.56	11.27	0.51	N	0.87	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9588	9588	G	A	MI.7442	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	382	128	E	K	Gaa/Aaa	-1.26	0	0	probably_damaging	0.92	neutral	0.29	neutral	2.15	neutral	-1.33	neutral	-1.62	low_impact	1.25	0.72	neutral	0.56	neutral	4.50	24.30	deleterious	0.11	0.4	0.15	neutral	0.57	disease	0.5	neutral	0.39	neutral	2	0.94	neutral	0.19	neutral	-2	neutral	0.69	deleterious	-1.9	low_impact	-0.03	medium_impact	-0.06	medium_impact	0.71	0.85	73.56	11.27	0.34	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9589	9589	A	T	MI.7443	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	383	128	E	V	gAa/gTa	5.22	1	0	probably_damaging	0.96	neutral	0.5	neutral	2.06	neutral	-2.92	deleterious	-3.92	medium_impact	2.65	0.61	neutral	0.54	neutral	4.09	23.70	deleterious	0.09	0.35	0.38	neutral	0.52	disease	0.49	neutral	0.46	neutral	1	0.95	neutral	0.27	neutral	1	deleterious	0.71	deleterious	-2.21	low_impact	0.19	medium_impact	1.19	medium_impact	0.39	0.8	73.56	11.27	0.5	N	0.83	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9589	9589	A	G	MI.7444	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	383	128	E	G	gAa/gGa	5.22	1	0	probably_damaging	0.96	neutral	0.33	neutral	2.1	neutral	-2.08	deleterious	-3.39	neutral_impact	0.38	0.66	neutral	0.67	neutral	3.13	22.60	deleterious	0.15	0.4	0.32	neutral	0.25	neutral	0.42	neutral	0.44	neutral	1	0.97	neutral	0.19	neutral	-2	neutral	0.68	deleterious	-2.21	low_impact	0.02	medium_impact	-0.84	medium_impact	0.28	0.8	73.56	11.27	0.51	P	0.62	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9589	9589	A	C	MI.7445	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	383	128	E	A	gAa/gCa	5.22	1	0	probably_damaging	0.94	neutral	0.51	neutral	2.12	neutral	-1.72	deleterious	-2.66	low_impact	1.37	0.65	neutral	0.65	neutral	3.53	23.10	deleterious	0.17	0.45	0.2	neutral	0.3	neutral	0.45	neutral	0.44	neutral	1	0.94	neutral	0.29	neutral	-2	neutral	0.67	deleterious	-2.03	low_impact	0.2	medium_impact	0.05	medium_impact	0.29	0.8	73.56	11.27	0.53	P	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9590	9590	A	C	MI.7446	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	384	128	E	D	gaA/gaC	8.69	1	0	possibly_damaging	0.74	neutral	0.21	neutral	2.14	neutral	-1.41	neutral	-1.55	low_impact	0.8	0.63	neutral	0.68	neutral	3.62	23.20	deleterious	0.3	0.45	0.27	neutral	0.29	neutral	0.31	neutral	0.44	neutral	1	0.85	neutral	0.24	neutral	-3	neutral	0.53	deleterious	-1.31	low_impact	-0.14	medium_impact	-0.47	medium_impact	0.67	0.85	73.56	11.27	0.68	P	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9590	9590	A	T	MI.7447	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	384	128	E	D	gaA/gaT	8.69	1	0	possibly_damaging	0.74	neutral	0.21	neutral	2.14	neutral	-1.41	neutral	-1.55	low_impact	0.8	0.63	neutral	0.68	neutral	3.76	23.30	deleterious	0.3	0.45	0.27	neutral	0.29	neutral	0.31	neutral	0.44	neutral	1	0.85	neutral	0.24	neutral	-3	neutral	0.53	deleterious	-1.31	low_impact	-0.14	medium_impact	-0.47	medium_impact	0.67	0.85	73.56	11.27	0.69	P	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9591	9591	G	C	MI.7448	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	385	129	V	L	Gtc/Ctc	2.67	1	0	probably_damaging	0.93	neutral	0.87	neutral	2.16	neutral	-0.76	neutral	-2.08	low_impact	1.2	0.6	damaging	0.53	neutral	1.69	14.35	neutral	0.28	0.45	0.09	neutral	0.42	neutral	0.47	neutral	0.41	neutral	2	0.92	neutral	0.47	deleterious	-2	neutral	0.58	deleterious	-1.96	low_impact	0.66	medium_impact	-0.11	medium_impact	0.46	0.8	75.48	11.31	0.4	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9591	9591	G	T	MI.7449	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	385	129	V	F	Gtc/Ttc	2.67	1	0	probably_damaging	1	neutral	0.38	neutral	1.93	deleterious	-3.49	deleterious	-4.01	medium_impact	2.32	0.56	damaging	0.52	neutral	3.71	23.30	deleterious	0.07	0.35	0.35	neutral	0.8	disease	0.69	disease	0.71	disease	4	1	deleterious	0.19	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	0.07	medium_impact	0.9	medium_impact	0.35	0.8	75.48	11.31	0.39	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8877	8877	T	A	MI.745	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	351	117	F	L	ttT/ttA	7.53	0.97	0.01	benign	0	neutral	0.97	neutral	4.5	neutral	-0.84	neutral	-1.16	neutral_impact	-0.11	0.95	neutral	0.89	neutral	-0.23	0.95	neutral	0.39	0.65	0.4	neutral	0.3	neutral	0.27	neutral	0.47	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.14	medium_impact	-1.19	low_impact	0.76	0.9	22.57	16.62	0.49	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9591	9591	G	A	MI.7450	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	385	129	V	I	Gtc/Atc	2.67	1	0	probably_damaging	0.93	neutral	0.37	neutral	2.23	neutral	-0.39	neutral	-0.16	neutral_impact	0.73	0.65	neutral	0.76	neutral	0.49	7.37	deleterious	0.45	0.55	0.13	neutral	0.07	neutral	0.34	neutral	0.23	neutral	5	0.93	neutral	0.22	neutral	-2	neutral	0.55	deleterious	-1.96	low_impact	0.06	medium_impact	-0.53	medium_impact	0.64	0.8	75.48	11.31	0.56	P	0.21	polymorphism	1	0.01	rs878949273	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9592	9592	T	C	MI.7451	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	386	129	V	A	gTc/gCc	3.6	1	0	probably_damaging	0.99	neutral	0.92	neutral	1.96	neutral	-2.78	deleterious	-3.84	medium_impact	2.88	0.62	neutral	0.65	neutral	3.47	23.00	deleterious	0.18	0.45	0.28	neutral	0.52	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.47	neutral	1	deleterious	0.72	deleterious	-2.81	low_impact	0.8	medium_impact	1.4	medium_impact	0.11	0.8	75.48	11.31	0.42	N	0.39	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9592	9592	T	A	MI.7452	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	386	129	V	D	gTc/gAc	3.6	1	0	probably_damaging	1	neutral	0.64	neutral	1.9	deleterious	-5.2	deleterious	-6.34	medium_impact	3.23	0.57	damaging	0.5	neutral	4.66	24.50	deleterious	0.02	0.35	0.67	disease	0.83	disease	0.75	disease	0.75	disease	5	1	deleterious	0.32	neutral	1	deleterious	0.82	deleterious	-3.78	low_impact	0.33	medium_impact	1.71	medium_impact	0.08	0.8	75.48	11.31	0.43	N	0.94	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9592	9592	T	G	MI.7453	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	386	129	V	G	gTc/gGc	3.6	1	0	probably_damaging	1	neutral	0.46	neutral	1.9	deleterious	-4.7	deleterious	-6.74	high_impact	3.92	0.59	damaging	0.6	neutral	3.87	23.50	deleterious	0.04	0.35	0.54	disease	0.67	disease	0.68	disease	0.69	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	0.15	medium_impact	2.33	high_impact	0.23	0.8	75.48	11.31	0.47	N	0.88	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9594	9594	C	G	MI.7454	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	388	130	P	A	Cca/Gca	-20	0	0	probably_damaging	0.98	neutral	0.51	neutral	1.89	neutral	-2.33	deleterious	-7.67	medium_impact	2.42	0.62	neutral	0.03	damaging	3.08	22.50	deleterious	0.17	0.45	0.16	neutral	0.6	disease	0.72	disease	0.67	disease	3	0.98	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-2.51	low_impact	0.2	medium_impact	0.99	medium_impact	0.63	0.8	73.95	11.67	0.23	N	0.70	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9594	9594	C	T	MI.7455	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	388	130	P	S	Cca/Tca	-20	0	0	probably_damaging	1	neutral	0.4	neutral	1.92	neutral	-2.05	deleterious	-7.67	high_impact	3.54	0.68	neutral	0.01	damaging	3.91	23.50	deleterious	0.2	0.45	0.23	neutral	0.78	disease	0.72	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.09	medium_impact	1.99	medium_impact	0.15	0.8	73.95	11.67	0.27	N	0.79	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9594	9594	C	A	MI.7456	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	388	130	P	T	Cca/Aca	-20	0	0	probably_damaging	1	neutral	0.44	neutral	1.84	deleterious	-3.06	deleterious	-7.67	high_impact	3.79	0.63	neutral	0.01	damaging	3.67	23.20	deleterious	0.15	0.4	0.25	neutral	0.75	disease	0.72	disease	0.67	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	0.13	medium_impact	2.21	high_impact	0.50	0.8	73.95	11.67	0.26	N	0.93	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9595	9595	C	A	MI.7457	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	389	130	P	Q	cCa/cAa	5.68	1	0	probably_damaging	1	neutral	0.33	neutral	1.8	deleterious	-3.93	deleterious	-7.68	high_impact	4.69	0.68	neutral	0.01	damaging	4.07	23.70	deleterious	0.11	0.4	0.27	neutral	0.84	disease	0.75	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.02	medium_impact	3.02	high_impact	0.32	0.8	73.95	11.67	0.58	P	0.86	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9595	9595	C	G	MI.7458	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	389	130	P	R	cCa/cGa	5.68	1	0	probably_damaging	1	neutral	0.35	neutral	1.8	deleterious	-3.87	deleterious	-8.64	high_impact	4.14	0.75	neutral	0.01	damaging	3.59	23.20	deleterious	0.05	0.35	0.28	neutral	0.84	disease	0.83	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	0.04	medium_impact	2.53	high_impact	0.37	0.8	73.95	11.67	0.53	N	0.93	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9595	9595	C	T	MI.7459	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	389	130	P	L	cCa/cTa	5.68	1	0	probably_damaging	1	neutral	0.81	neutral	1.8	deleterious	-3.93	deleterious	-9.6	high_impact	4	0.59	damaging	0.02	damaging	4.41	24.10	deleterious	0.13	0.4	0.27	neutral	0.83	disease	0.69	disease	0.68	disease	4	1	deleterious	0.41	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	0.55	medium_impact	2.4	high_impact	0.59	0.8	73.95	11.67	0.41	N	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8877	8877	T	G	MI.746	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	351	117	F	L	ttT/ttG	7.53	0.97	0.01	benign	0	neutral	0.97	neutral	4.5	neutral	-0.84	neutral	-1.16	neutral_impact	-0.11	0.95	neutral	0.89	neutral	-0.33	0.58	neutral	0.39	0.65	0.4	neutral	0.3	neutral	0.27	neutral	0.47	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.14	medium_impact	-1.19	low_impact	0.76	0.9	22.57	16.62	0.49	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9597	9597	C	T	MI.7460	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	391	131	L	F	Ctc/Ttc	-15.37	0	0	probably_damaging	0.99	neutral	0.11	neutral	1.61	neutral	-2.99	deleterious	-3.85	medium_impact	2.53	0.46	damaging	0.03	damaging	3.93	23.50	deleterious	0.21	0.45	0.27	neutral	0.46	neutral	0.47	neutral	0.37	neutral	3	0.99	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-2.81	low_impact	-0.33	medium_impact	1.09	medium_impact	0.56	0.8	73.95	11.81	0.33	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9597	9597	C	G	MI.7461	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	391	131	L	V	Ctc/Gtc	-15.37	0	0	probably_damaging	0.91	neutral	0.18	neutral	1.6	deleterious	-3.14	deleterious	-2.88	medium_impact	3.29	0.52	damaging	0.01	damaging	3.46	23.00	deleterious	0.3	0.45	0.26	neutral	0.47	neutral	0.68	disease	0.49	neutral	0	0.95	neutral	0.14	neutral	1	deleterious	0.66	deleterious	-1.85	low_impact	-0.18	medium_impact	1.77	medium_impact	0.56	0.8	73.95	11.81	0.3	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9597	9597	C	A	MI.7462	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	391	131	L	I	Ctc/Atc	-15.37	0	0	probably_damaging	0.96	neutral	0.24	neutral	1.62	neutral	-2.9	neutral	-1.92	medium_impact	3.14	0.57	damaging	0.02	damaging	4.10	23.70	deleterious	0.3	0.45	0.28	neutral	0.47	neutral	0.58	disease	0.44	neutral	1	0.97	neutral	0.14	neutral	1	deleterious	0.68	deleterious	-2.21	low_impact	-0.09	medium_impact	1.63	medium_impact	0.52	0.8	73.95	11.81	0.32	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9598	9598	T	G	MI.7463	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	392	131	L	R	cTc/cGc	0.13	0.02	0	probably_damaging	0.99	neutral	0.1	neutral	1.49	deleterious	-5.86	deleterious	-5.77	high_impact	4.26	0.67	neutral	0.02	damaging	4.22	23.90	deleterious	0.02	0.35	0.52	disease	0.8	disease	0.79	disease	0.7	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.83	deleterious	-2.81	low_impact	-0.35	medium_impact	2.64	high_impact	0.13	0.8	73.95	11.81	0.44	N	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9598	9598	T	C	MI.7464	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	392	131	L	P	cTc/cCc	0.13	0.02	0	probably_damaging	1	neutral	0.25	neutral	1.48	deleterious	-6.55	deleterious	-6.75	high_impact	4.26	0.53	damaging	0.03	damaging	3.98	23.60	deleterious	0.03	0.35	0.63	disease	0.75	disease	0.79	disease	0.71	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.08	medium_impact	2.64	high_impact	0.26	0.8	73.95	11.81	0.36	N	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9598	9598	T	A	MI.7465	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	392	131	L	H	cTc/cAc	0.13	0.02	0	probably_damaging	1	neutral	0.09	neutral	1.48	deleterious	-6.33	deleterious	-6.74	high_impact	4.61	0.55	damaging	0.02	damaging	4.33	24.00	deleterious	0.05	0.35	0.63	disease	0.77	disease	0.76	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.38	medium_impact	2.95	high_impact	0.20	0.8	73.95	11.81	0.44	N	0.97	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9600	9600	C	G	MI.7466	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	394	132	L	V	Cta/Gta	-6.81	0	0	probably_damaging	0.98	neutral	0.18	neutral	1.6	deleterious	-3.13	deleterious	-2.92	medium_impact	2.62	0.49	damaging	0.02	damaging	3.43	23.00	deleterious	0.32	0.5	0.21	neutral	0.5	neutral	0.58	disease	0.55	disease	1	0.98	deleterious	0.1	neutral	1	deleterious	0.69	deleterious	-2.51	low_impact	-0.18	medium_impact	1.17	medium_impact	0.58	0.8	73.95	11.73	0.3	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9600	9600	C	A	MI.7467	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	394	132	L	M	Cta/Ata	-6.81	0	0	probably_damaging	1	neutral	0.08	neutral	1.55	deleterious	-3.87	neutral	-1.94	medium_impact	3.13	0.59	damaging	0.05	damaging	3.76	23.30	deleterious	0.27	0.45	0.43	neutral	0.5	neutral	0.55	disease	0.47	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.41	medium_impact	1.62	medium_impact	0.55	0.8	73.95	11.73	0.29	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9601	9601	T	A	MI.7468	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	395	132	L	Q	cTa/cAa	-0.1	0	0	probably_damaging	1	neutral	0.13	neutral	1.49	deleterious	-5.84	deleterious	-5.84	high_impact	4.55	0.6	damaging	0.02	damaging	4.11	23.70	deleterious	0.02	0.35	0.68	disease	0.8	disease	0.58	disease	0.65	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.28	medium_impact	2.9	high_impact	0.33	0.8	73.95	11.73	0.38	N	0.97	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9601	9601	T	C	MI.7469	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	395	132	L	P	cTa/cCa	-0.1	0	0	probably_damaging	1	neutral	0.2	neutral	1.49	deleterious	-6.54	deleterious	-6.82	medium_impact	3.13	0.56	damaging	0.03	damaging	3.94	23.50	deleterious	0.02	0.35	0.73	disease	0.79	disease	0.75	disease	0.72	disease	4	1	deleterious	0.1	neutral	1	deleterious	0.86	deleterious	-3.78	low_impact	-0.15	medium_impact	1.62	medium_impact	0.26	0.8	73.95	11.73	0.26	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8878	8878	C	G	MI.747	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	352	118	R	G	Cgc/Ggc	-6.12	0	0	probably_damaging	0.99	neutral	0.33	neutral	4.33	neutral	-1.95	deleterious	-6.39	medium_impact	3.02	0.69	neutral	0.46	neutral	4.17	23.80	deleterious	0.23	0.65	0.75	disease	0.88	disease	0.64	disease	0.71	disease	4	0.99	deleterious	0.17	neutral	1	deleterious	0.84	deleterious	-2.65	low_impact	0.12	medium_impact	1.49	medium_impact	0.46	0.9	47.35	8.78	0.27	N	1.00	polymorphism	0.98	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9601	9601	T	G	MI.7470	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	395	132	L	R	cTa/cGa	-0.1	0	0	probably_damaging	1	neutral	0.12	neutral	1.49	deleterious	-5.86	deleterious	-5.84	high_impact	4.21	0.67	neutral	0.02	damaging	4.18	23.80	deleterious	0.01	0.35	0.66	disease	0.82	disease	0.74	disease	0.72	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.3	medium_impact	2.59	high_impact	0.20	0.8	73.95	11.73	0.38	N	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9603	9603	A	T	MI.7471	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	397	133	N	Y	Aac/Tac	-7.97	0	0	probably_damaging	1	neutral	1	neutral	1.83	deleterious	-5.06	deleterious	-7.79	high_impact	4.38	0.55	damaging	0.17	damaging	3.74	23.30	deleterious	0.07	0.35	0.47	neutral	0.85	disease	0.74	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.80	deleterious	-3.78	low_impact	1.9	high_impact	2.74	high_impact	0.21	0.8	73.95	11.62	0.34	N	1.00	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9603	9603	A	G	MI.7472	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	397	133	N	D	Aac/Gac	-7.97	0	0	probably_damaging	0.96	neutral	0.22	neutral	1.94	neutral	-2.14	deleterious	-4.87	high_impact	4.38	0.54	damaging	0.37	neutral	3.86	23.50	deleterious	0.25	0.45	0.4	neutral	0.76	disease	0.79	disease	0.7	disease	4	0.98	neutral	0.13	neutral	2	deleterious	0.73	deleterious	-2.21	low_impact	-0.12	medium_impact	2.74	high_impact	0.33	0.8	73.95	11.62	0.55	N	0.97	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9603	9603	A	C	MI.7473	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	397	133	N	H	Aac/Cac	-7.97	0	0	probably_damaging	1	neutral	0.54	neutral	1.84	deleterious	-4.29	deleterious	-4.87	high_impact	4.74	0.54	damaging	0.28	damaging	3.11	22.50	deleterious	0.2	0.45	0.49	neutral	0.82	disease	0.8	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	0.23	medium_impact	3.07	high_impact	0.28	0.8	73.95	11.62	0.65	P	0.96	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9604	9604	A	C	MI.7474	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	398	133	N	T	aAc/aCc	8.69	1	0.01	probably_damaging	0.98	neutral	0.65	neutral	1.87	deleterious	-3.37	deleterious	-5.84	high_impact	4.74	0.58	damaging	0.42	neutral	3.41	23.00	deleterious	0.16	0.45	0.29	neutral	0.79	disease	0.73	disease	0.69	disease	4	0.97	neutral	0.34	neutral	2	deleterious	0.75	deleterious	-2.51	low_impact	0.35	medium_impact	3.07	high_impact	0.30	0.8	73.95	11.62	0.64	P	0.87	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9604	9604	A	T	MI.7475	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	398	133	N	I	aAc/aTc	8.69	1	0.01	probably_damaging	1	neutral	0.46	neutral	1.83	deleterious	-4.65	deleterious	-8.77	medium_impact	3.38	0.56	damaging	0.48	neutral	3.85	23.40	deleterious	0.08	0.35	0.25	neutral	0.87	disease	0.74	disease	0.69	disease	4	1	deleterious	0.23	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.15	medium_impact	1.85	medium_impact	0.19	0.8	73.95	11.62	0.51	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9604	9604	A	G	MI.7476	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	398	133	N	S	aAc/aGc	8.69	1	0.01	probably_damaging	0.91	neutral	0.62	neutral	1.89	neutral	-2.84	deleterious	-4.87	high_impact	3.84	0.5	damaging	0.41	neutral	2.99	22.20	deleterious	0.34	0.5	0.28	neutral	0.79	disease	0.71	disease	0.69	disease	4	0.89	neutral	0.36	neutral	2	deleterious	0.73	deleterious	-1.85	low_impact	0.31	medium_impact	2.26	high_impact	0.39	0.8	73.95	11.62	0.58	P	0.94	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9605	9605	C	G	MI.7477	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	399	133	N	K	aaC/aaG	8.69	1	0	probably_damaging	0.99	neutral	0.31	neutral	1.91	neutral	-2.6	deleterious	-5.84	high_impact	4.18	0.53	damaging	0.26	damaging	3.99	23.60	deleterious	0.18	0.45	0.28	neutral	0.83	disease	0.79	disease	0.7	disease	4	0.99	deleterious	0.16	neutral	2	deleterious	0.77	deleterious	-2.81	low_impact	-0.01	medium_impact	2.56	high_impact	0.36	0.8	73.95	11.62	0.59	P	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9605	9605	C	A	MI.7478	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	399	133	N	K	aaC/aaA	8.69	1	0	probably_damaging	0.99	neutral	0.31	neutral	1.91	neutral	-2.6	deleterious	-5.84	high_impact	4.18	0.53	damaging	0.26	damaging	4.41	24.10	deleterious	0.18	0.45	0.28	neutral	0.83	disease	0.79	disease	0.7	disease	4	0.99	deleterious	0.16	neutral	2	deleterious	0.77	deleterious	-2.81	low_impact	-0.01	medium_impact	2.56	high_impact	0.36	0.8	73.95	11.62	0.6	P	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9606	9606	A	C	MI.7479	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	400	134	T	P	Aca/Cca	-3.11	0	0	possibly_damaging	0.85	neutral	0.21	neutral	0.95	deleterious	-8.08	deleterious	-5.84	high_impact	4.78	0.64	neutral	0.06	damaging	3.41	23.00	deleterious	0.02	0.35	0.71	disease	0.72	disease	0.83	disease	0.74	disease	5	0.91	neutral	0.18	neutral	1	deleterious	0.75	deleterious	-1.6	low_impact	-0.14	medium_impact	3.1	high_impact	0.28	0.8	75.1	11.46	0.6	P	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8878	8878	C	A	MI.748	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	352	118	R	S	Cgc/Agc	-6.12	0	0	probably_damaging	0.99	neutral	0.4	neutral	4.42	neutral	-1.19	deleterious	-5.42	low_impact	1.48	0.7	neutral	0.48	neutral	4.54	24.30	deleterious	0.19	0.65	0.45	neutral	0.89	disease	0.54	disease	0.63	disease	3	0.99	deleterious	0.21	neutral	-2	neutral	0.82	deleterious	-2.65	low_impact	0.19	medium_impact	0.17	medium_impact	0.39	0.9	47.35	8.78	0.26	N	0.77	polymorphism	0.98	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9606	9606	A	G	MI.7480	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	400	134	T	A	Aca/Gca	-3.11	0	0	benign	0.11	neutral	0.49	neutral	0.97	deleterious	-6.55	deleterious	-4.87	high_impact	4.22	0.65	neutral	0.04	damaging	2.98	22.20	deleterious	0.03	0.35	0.39	neutral	0.54	disease	0.74	disease	0.69	disease	4	0.43	neutral	0.69	deleterious	-2	neutral	0.26	neutral	0.01	medium_impact	0.18	medium_impact	2.6	high_impact	0.33	0.8	75.1	11.46	0.38	N	0.44	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9606	9606	A	T	MI.7481	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	400	134	T	S	Aca/Tca	-3.11	0	0	benign	0.24	neutral	0.34	neutral	1.14	deleterious	-3.81	deleterious	-3.9	medium_impact	3.09	0.66	neutral	0.07	damaging	3.05	22.40	deleterious	0.08	0.35	0.36	neutral	0.6	disease	0.57	disease	0.39	neutral	2	0.59	neutral	0.55	deleterious	-3	neutral	0.33	neutral	-0.38	medium_impact	0.03	medium_impact	1.59	medium_impact	0.48	0.8	75.1	11.46	0.31	N	0.77	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9607	9607	C	T	MI.7482	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	401	134	T	M	aCa/aTa	8.69	1	0	possibly_damaging	0.82	neutral	0.19	neutral	0.94	deleterious	-9.09	deleterious	-5.84	high_impact	4.78	0.69	neutral	0.01	damaging	4.07	23.70	deleterious	0.03	0.35	0.73	disease	0.7	disease	0.76	disease	0.72	disease	4	0.9	neutral	0.19	neutral	1	deleterious	0.71	deleterious	-1.51	low_impact	-0.17	medium_impact	3.1	high_impact	0.49	0.8	75.1	11.46	0.63	P	0.96	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9607	9607	C	A	MI.7483	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	401	134	T	K	aCa/aAa	8.69	1	0	possibly_damaging	0.6	neutral	0.24	neutral	0.95	deleterious	-7.92	deleterious	-5.84	high_impact	4.43	0.69	neutral	0.02	damaging	4.49	24.30	deleterious	0.03	0.35	0.58	disease	0.78	disease	0.81	disease	0.73	disease	5	0.77	neutral	0.32	neutral	1	deleterious	0.65	deleterious	-1.04	low_impact	-0.09	medium_impact	2.79	high_impact	0.43	0.8	75.1	11.46	0.58	P	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9609	9609	T	G	MI.7484	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	403	135	S	A	Tcc/Gcc	-2.88	0	0	benign	0	neutral	0.7	neutral	2.69	neutral	1.25	neutral	1.31	neutral_impact	-1.64	0.63	neutral	0.52	neutral	-0.87	0.03	neutral	0.21	0.45	0.11	neutral	0.04	neutral	0.25	neutral	0.18	neutral	6	0.29	neutral	0.85	deleterious	-6	neutral	0.11	neutral	2.05	high_impact	0.4	medium_impact	-2.65	low_impact	0.60	0.8	21.46	24.65	0.34	N	0.40	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9609	9609	T	C	MI.7485	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	403	135	S	P	Tcc/Ccc	-2.88	0	0	possibly_damaging	0.52	neutral	0.15	neutral	2.56	neutral	-2.09	neutral	-1.84	low_impact	0.94	0.44	damaging	0.09	damaging	3.95	23.60	deleterious	0.06	0.35	0.26	neutral	0.63	disease	0.57	disease	0.64	disease	3	0.84	neutral	0.32	neutral	-3	neutral	0.45	deleterious	-0.9	medium_impact	-0.24	medium_impact	-0.34	medium_impact	0.42	0.8	21.46	24.65	0.36	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9609	9609	T	A	MI.7486	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	403	135	S	T	Tcc/Acc	-2.88	0	0	benign	0.06	neutral	0.62	neutral	2.6	neutral	0.15	neutral	-0.23	neutral_impact	-0.43	0.62	neutral	0.23	damaging	0.97	10.49	neutral	0.21	0.45	0.16	neutral	0.11	neutral	0.28	neutral	0.3	neutral	4	0.31	neutral	0.78	deleterious	-6	neutral	0.13	neutral	0.29	medium_impact	0.31	medium_impact	-1.57	low_impact	0.64	0.8	21.46	24.65	0.28	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9610	9610	C	T	MI.7487	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	404	135	S	F	tCc/tTc	1.52	0.96	0	possibly_damaging	0.89	neutral	0.58	neutral	2.67	neutral	0.79	neutral	-1.89	neutral_impact	-0.04	0.45	damaging	0.14	damaging	4.16	23.80	deleterious	0.08	0.35	0.16	neutral	0.43	neutral	0.45	neutral	0.45	neutral	1	0.87	neutral	0.35	neutral	-3	neutral	0.64	deleterious	-1.75	low_impact	0.27	medium_impact	-1.22	low_impact	0.30	0.8	21.46	24.65	0.42	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9610	9610	C	A	MI.7488	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	404	135	S	Y	tCc/tAc	1.52	0.96	0	possibly_damaging	0.89	neutral	0.8	neutral	2.58	neutral	-0.87	neutral	-2.15	low_impact	1.56	0.47	damaging	0.12	damaging	4.13	23.80	deleterious	0.07	0.35	0.29	neutral	0.38	neutral	0.44	neutral	0.45	neutral	1	0.87	neutral	0.46	neutral	-3	neutral	0.65	deleterious	-1.75	low_impact	0.54	medium_impact	0.22	medium_impact	0.44	0.8	21.46	24.65	0.41	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9610	9610	C	G	MI.7489	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	404	135	S	C	tCc/tGc	1.52	0.96	0	possibly_damaging	0.82	neutral	0.13	neutral	2.54	neutral	-2.08	neutral	-0.96	low_impact	1.22	0.48	damaging	0.2	damaging	3.51	23.10	deleterious	0.06	0.35	0.41	neutral	0.38	neutral	0.43	neutral	0.47	neutral	1	0.93	neutral	0.16	neutral	-3	neutral	0.60	deleterious	-1.51	low_impact	-0.28	medium_impact	-0.09	medium_impact	0.39	0.8	21.46	24.65	0.51	P	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8878	8878	C	T	MI.749	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	352	118	R	C	Cgc/Tgc	-6.12	0	0	probably_damaging	1	neutral	0.18	neutral	4.31	deleterious	-4.83	deleterious	-7.1	medium_impact	2.82	0.7	neutral	0.29	neutral	4.96	25.00	deleterious	0.24	0.65	0.93	disease	0.93	disease	0.65	disease	0.77	disease	5	1	deleterious	0.09	neutral	1	deleterious	0.89	deleterious	-3.6	low_impact	-0.08	medium_impact	1.32	medium_impact	0.74	0.9	47.35	8.78	0.26	N	1.00	disease_causing	0.87	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9612	9612	G	A	MI.7490	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	406	136	V	M	Gta/Ata	-20	0	0.01	probably_damaging	1	neutral	0.07	neutral	2.04	neutral	-2.78	neutral	-2.35	high_impact	3.63	0.66	neutral	0.5	neutral	3.75	23.30	deleterious	0.16	0.45	0.5	disease	0.63	disease	0.62	disease	0.69	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.74	deleterious	-3.78	low_impact	-0.45	medium_impact	2.07	high_impact	0.80	0.85	67.82	10.97	0.39	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9612	9612	G	C	MI.7491	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	406	136	V	L	Gta/Cta	-20	0	0.01	probably_damaging	0.92	neutral	1	neutral	2.24	neutral	-0.44	neutral	-1.85	low_impact	1.23	0.69	neutral	0.48	neutral	3.64	23.20	deleterious	0.16	0.45	0.18	neutral	0.57	disease	0.39	neutral	0.33	neutral	4	0.92	neutral	0.54	deleterious	-2	neutral	0.62	deleterious	-1.9	low_impact	1.9	high_impact	-0.08	medium_impact	0.46	0.8	67.82	10.97	0.27	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9612	9612	G	T	MI.7492	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	406	136	V	L	Gta/Tta	-20	0	0.01	probably_damaging	0.92	neutral	1	neutral	2.24	neutral	-0.44	neutral	-1.85	low_impact	1.23	0.69	neutral	0.48	neutral	3.75	23.30	deleterious	0.16	0.45	0.18	neutral	0.57	disease	0.39	neutral	0.33	neutral	4	0.92	neutral	0.54	deleterious	-2	neutral	0.62	deleterious	-1.9	low_impact	1.9	high_impact	-0.08	medium_impact	0.46	0.8	67.82	10.97	0.27	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9613	9613	T	G	MI.7493	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	407	136	V	G	gTa/gGa	1.52	0.92	0	probably_damaging	1	neutral	0.12	neutral	2	deleterious	-4.68	deleterious	-6.65	high_impact	3.98	0.62	neutral	0.61	neutral	3.88	23.50	deleterious	0.03	0.35	0.8	disease	0.76	disease	0.64	disease	0.71	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.3	medium_impact	2.38	high_impact	0.30	0.8	67.82	10.97	0.43	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9613	9613	T	C	MI.7494	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	407	136	V	A	gTa/gCa	1.52	0.92	0	probably_damaging	0.99	neutral	0.37	neutral	2.04	neutral	-2.65	deleterious	-3.76	high_impact	3.63	0.62	neutral	0.63	neutral	3.61	23.20	deleterious	0.09	0.35	0.5	disease	0.55	disease	0.59	disease	0.67	disease	3	0.99	deleterious	0.19	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	0.06	medium_impact	2.07	high_impact	0.28	0.8	67.82	10.97	0.42	N	0.84	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9613	9613	T	A	MI.7495	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	407	136	V	E	gTa/gAa	1.52	0.92	0	probably_damaging	0.99	neutral	0.07	neutral	2	deleterious	-4.44	deleterious	-5.68	high_impact	3.98	0.62	neutral	0.41	neutral	4.68	24.50	deleterious	0.03	0.35	0.8	disease	0.89	disease	0.75	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.88	deleterious	-2.81	low_impact	-0.45	medium_impact	2.38	high_impact	0.24	0.8	67.82	10.97	0.46	N	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9615	9615	T	A	MI.7496	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	409	137	L	M	Tta/Ata	-10.28	0	0.01	probably_damaging	1	neutral	0.12	neutral	0.58	deleterious	-6.26	neutral	-1.95	high_impact	4.8	0.59	damaging	0.55	neutral	3.60	23.20	deleterious	0.06	0.35	0.62	disease	0.58	disease	0.74	disease	0.7	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	-0.3	medium_impact	3.12	high_impact	0.43	0.8	73.56	11.67	0.69	P	0.85	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9615	9615	T	G	MI.7497	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	409	137	L	V	Tta/Gta	-10.28	0	0.01	probably_damaging	0.98	neutral	0.36	neutral	0.58	deleterious	-6.21	deleterious	-2.92	high_impact	4.8	0.47	damaging	0.38	neutral	3.45	23.00	deleterious	0.05	0.35	0.54	disease	0.61	disease	0.76	disease	0.71	disease	4	0.98	neutral	0.19	neutral	2	deleterious	0.77	deleterious	-2.51	low_impact	0.05	medium_impact	3.12	high_impact	0.55	0.8	73.56	11.67	0.65	P	0.81	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9616	9616	T	C	MI.7498	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	410	137	L	S	tTa/tCa	0.13	0	0	probably_damaging	1	neutral	0.81	neutral	0.52	deleterious	-10.18	deleterious	-5.85	high_impact	4.8	0.5	damaging	0.44	neutral	3.82	23.40	deleterious	0.02	0.35	0.82	disease	0.8	disease	0.72	disease	0.7	disease	4	1	deleterious	0.41	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	0.55	medium_impact	3.12	high_impact	0.22	0.8	73.56	11.67	0.57	P	0.92	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9616	9616	T	G	MI.7499	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	410	137	L	W	tTa/tGa	0.13	0	0	probably_damaging	1	deleterious	0.01	neutral	0.52	deleterious	-10.27	deleterious	-5.85	high_impact	4.8	0.59	damaging	0.37	neutral	3.77	23.40	deleterious	0.03	0.35	0.92	disease	0.74	disease	0.77	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.78	low_impact	-0.95	medium_impact	3.12	high_impact	0.20	0.8	73.56	11.67	0.58	P	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8558	8558	C	T	MI.75	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	32	11	A	V	gCc/gTc	1.05	0.01	0	benign	0.19	neutral	0.11	neutral	4.65	neutral	-0.5	neutral	-1.14	neutral_impact	0	0.96	neutral	0.94	neutral	4.14	23.80	deleterious	0.37	0.65	0.57	disease	0.59	disease	0.36	neutral	0.51	disease	0	0.87	neutral	0.46	neutral	-6	neutral	0.30	neutral	-0.16	medium_impact	-0.22	medium_impact	-1.1	low_impact	0.65	0.9	23.45	19.76	0.57	P	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	C8558T	Possibly LVNC cardiomyopathy-associated	+	-	Reported	1	.	P	P	neutral
chrM	8879	8879	G	A	MI.750	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	353	118	R	H	cGc/cAc	0.59	0.43	0	probably_damaging	1	neutral	0.54	neutral	4.32	neutral	-2.88	deleterious	-4.56	medium_impact	3.37	0.66	neutral	0.29	neutral	4.42	24.20	deleterious	0.36	0.65	0.78	disease	0.85	disease	0.49	neutral	0.69	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.85	deleterious	-3.6	low_impact	0.33	medium_impact	1.79	medium_impact	0.77	0.9	47.35	8.78	0.26	N	1.00	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9617	9617	A	T	MI.7500	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	411	137	L	F	ttA/ttT	7.53	0.97	0	probably_damaging	1	deleterious	0.04	neutral	0.57	deleterious	-6.52	deleterious	-3.9	high_impact	4.8	0.46	damaging	0.4	neutral	3.62	23.20	deleterious	0.04	0.35	0.64	disease	0.72	disease	0.75	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-3.78	low_impact	-0.6	medium_impact	3.12	high_impact	0.42	0.8	73.56	11.67	0.76	P	0.95	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9617	9617	A	C	MI.7501	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	411	137	L	F	ttA/ttC	7.53	0.97	0	probably_damaging	1	deleterious	0.04	neutral	0.57	deleterious	-6.52	deleterious	-3.9	high_impact	4.8	0.46	damaging	0.4	neutral	3.48	23.10	deleterious	0.04	0.35	0.64	disease	0.72	disease	0.75	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-3.78	low_impact	-0.6	medium_impact	3.12	high_impact	0.42	0.8	73.56	11.67	0.76	P	0.95	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9618	9618	C	G	MI.7502	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	412	138	L	V	Ctc/Gtc	-15.6	0	0	probably_damaging	0.91	neutral	0.68	neutral	1.76	neutral	-2.19	deleterious	-2.79	low_impact	1.91	0.55	damaging	0.04	damaging	3.48	23.10	deleterious	0.23	0.45	0.22	neutral	0.58	disease	0.63	disease	0.38	neutral	2	0.9	neutral	0.39	neutral	-2	neutral	0.64	deleterious	-1.85	low_impact	0.38	medium_impact	0.53	medium_impact	0.54	0.8	73.95	11.76	0.2	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9618	9618	C	A	MI.7503	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	412	138	L	I	Ctc/Atc	-15.6	0	0	probably_damaging	0.96	neutral	0.68	neutral	1.77	neutral	-2.07	neutral	-1.82	medium_impact	2.38	0.55	damaging	0.08	damaging	4.11	23.70	deleterious	0.27	0.45	0.29	neutral	0.53	disease	0.47	neutral	0.2	neutral	6	0.96	neutral	0.36	neutral	1	deleterious	0.66	deleterious	-2.21	low_impact	0.38	medium_impact	0.95	medium_impact	0.52	0.8	73.95	11.76	0.23	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9618	9618	C	T	MI.7504	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	412	138	L	F	Ctc/Ttc	-15.6	0	0	probably_damaging	0.99	neutral	0.1	neutral	1.61	deleterious	-4.05	deleterious	-3.84	high_impact	4.04	0.57	damaging	0.02	damaging	4.01	23.60	deleterious	0.16	0.45	0.43	neutral	0.76	disease	0.69	disease	0.66	disease	3	0.99	deleterious	0.06	neutral	2	deleterious	0.78	deleterious	-2.81	low_impact	-0.35	medium_impact	2.44	high_impact	0.47	0.8	73.95	11.76	0.27	N	0.95	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9619	9619	T	C	MI.7505	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	413	138	L	P	cTc/cCc	-0.1	0	0	probably_damaging	1	neutral	0.06	neutral	1.56	deleterious	-6.4	deleterious	-6.76	high_impact	4.04	0.52	damaging	0.03	damaging	4.00	23.60	deleterious	0.01	0.35	0.49	neutral	0.83	disease	0.79	disease	0.71	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.49	medium_impact	2.44	high_impact	0.36	0.8	73.95	11.76	0.35	N	0.99	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9619	9619	T	G	MI.7506	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	413	138	L	R	cTc/cGc	-0.1	0	0	probably_damaging	0.99	neutral	0.05	neutral	1.57	deleterious	-5.71	deleterious	-5.82	high_impact	4.59	0.65	neutral	0.03	damaging	4.24	23.90	deleterious	0.01	0.35	0.55	disease	0.87	disease	0.79	disease	0.74	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.54	medium_impact	2.93	high_impact	0.17	0.8	73.95	11.76	0.49	N	0.99	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9619	9619	T	A	MI.7507	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	413	138	L	H	cTc/cAc	-0.1	0	0	probably_damaging	1	deleterious	0.03	neutral	1.56	deleterious	-6.61	deleterious	-6.76	high_impact	4.59	0.6	damaging	0.02	damaging	4.27	23.90	deleterious	0.03	0.35	0.65	disease	0.83	disease	0.76	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.78	low_impact	-0.67	medium_impact	2.93	high_impact	0.26	0.8	73.95	11.76	0.42	N	0.97	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9621	9621	G	A	MI.7508	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	415	139	A	T	Gca/Aca	-1.03	0	0	probably_damaging	1	neutral	0.39	neutral	2.6	neutral	0.54	neutral	-1.05	neutral_impact	0.71	0.64	neutral	0.7	neutral	3.12	22.60	deleterious	0.14	0.4	0.17	neutral	0.37	neutral	0.39	neutral	0.43	neutral	1	1	deleterious	0.2	neutral	-2	neutral	0.68	deleterious	-3.78	low_impact	0.08	medium_impact	-0.55	medium_impact	0.80	0.85	73.18	11.54	0.42	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9621	9621	G	C	MI.7509	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	415	139	A	P	Gca/Cca	-1.03	0	0	probably_damaging	1	neutral	0.2	neutral	2.45	deleterious	-3.42	deleterious	-3.09	medium_impact	2.77	0.54	damaging	0.38	neutral	3.86	23.50	deleterious	0.03	0.35	0.5	disease	0.84	disease	0.75	disease	0.75	disease	5	1	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-3.78	low_impact	-0.15	medium_impact	1.3	medium_impact	0.62	0.8	73.18	11.54	0.33	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8879	8879	G	T	MI.751	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	353	118	R	L	cGc/cTc	0.59	0.43	0	probably_damaging	0.99	neutral	0.66	neutral	4.38	neutral	-2.12	deleterious	-6.32	low_impact	1.51	0.71	neutral	0.39	neutral	4.31	24.00	deleterious	0.3	0.65	0.74	disease	0.92	disease	0.53	disease	0.54	disease	1	0.99	deleterious	0.34	neutral	-2	neutral	0.87	deleterious	-2.65	low_impact	0.45	medium_impact	0.2	medium_impact	0.35	0.9	47.35	8.78	0.22	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9621	9621	G	T	MI.7510	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	415	139	A	S	Gca/Tca	-1.03	0	0	probably_damaging	1	neutral	0.45	neutral	2.65	neutral	-0.05	neutral	-0.13	neutral_impact	-0.3	0.62	neutral	0.66	neutral	2.41	18.86	deleterious	0.24	0.45	0.17	neutral	0.14	neutral	0.3	neutral	0.22	neutral	6	0.99	deleterious	0.23	neutral	-2	neutral	0.66	deleterious	-3.78	low_impact	0.14	medium_impact	-1.45	low_impact	0.53	0.8	73.18	11.54	0.41	N	0.89	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9622	9622	C	T	MI.7511	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	416	139	A	V	gCa/gTa	9.38	1	0	probably_damaging	1	neutral	0.52	neutral	2.54	neutral	-0.45	deleterious	-2.82	medium_impact	2.05	0.57	damaging	0.63	neutral	4.55	24.30	deleterious	0.12	0.4	0.2	neutral	0.6	disease	0.64	disease	0.69	disease	4	0.99	deleterious	0.26	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	0.21	medium_impact	0.66	medium_impact	0.78	0.85	73.18	11.54	0.58	P	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9622	9622	C	G	MI.7512	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	416	139	A	G	gCa/gGa	9.38	1	0	probably_damaging	0.99	neutral	0.35	neutral	2.46	neutral	-2.29	neutral	-2.2	low_impact	1.5	0.58	damaging	0.62	neutral	3.97	23.60	deleterious	0.22	0.45	0.41	neutral	0.53	disease	0.56	disease	0.33	neutral	3	0.99	deleterious	0.18	neutral	-2	neutral	0.71	deleterious	-2.81	low_impact	0.04	medium_impact	0.16	medium_impact	0.68	0.85	73.18	11.54	0.51	P	0.67	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9622	9622	C	A	MI.7513	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	416	139	A	E	gCa/gAa	9.38	1	0	probably_damaging	1	neutral	0.27	neutral	2.45	neutral	-2.61	deleterious	-2.8	medium_impact	3.23	0.56	damaging	0.4	neutral	4.58	24.40	deleterious	0.03	0.35	0.32	neutral	0.82	disease	0.73	disease	0.74	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	-0.06	medium_impact	1.71	medium_impact	0.33	0.8	73.18	11.54	0.56	P	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9624	9624	T	C	MI.7514	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	418	140	S	P	Tca/Cca	-6.81	0	0	probably_damaging	0.99	neutral	0.26	neutral	1.21	deleterious	-7.13	deleterious	-4.87	high_impact	4.09	0.5	damaging	0.06	damaging	4.03	23.60	deleterious	0.03	0.35	0.78	disease	0.82	disease	0.87	disease	0.73	disease	5	0.99	deleterious	0.14	neutral	2	deleterious	0.87	deleterious	-2.81	low_impact	-0.07	medium_impact	2.48	high_impact	0.28	0.8	73.56	11.73	0.39	N	0.98	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9624	9624	T	G	MI.7515	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	418	140	S	A	Tca/Gca	-6.81	0	0	probably_damaging	0.96	neutral	0.61	neutral	1.36	deleterious	-3.79	deleterious	-2.92	high_impact	4.79	0.57	damaging	0.1	damaging	3.78	23.40	deleterious	0.07	0.35	0.49	neutral	0.61	disease	0.75	disease	0.71	disease	4	0.95	neutral	0.33	neutral	2	deleterious	0.68	deleterious	-2.21	low_impact	0.3	medium_impact	3.11	high_impact	0.40	0.8	73.56	11.73	0.63	P	0.40	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9624	9624	T	A	MI.7516	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	418	140	S	T	Tca/Aca	-6.81	0	0	probably_damaging	0.92	neutral	0.46	neutral	1.3	deleterious	-4.47	deleterious	-2.92	high_impact	3.82	0.55	damaging	0.04	damaging	3.85	23.40	deleterious	0.08	0.35	0.61	disease	0.68	disease	0.79	disease	0.69	disease	4	0.92	neutral	0.27	neutral	2	deleterious	0.77	deleterious	-1.9	low_impact	0.15	medium_impact	2.24	high_impact	0.51	0.8	73.56	11.73	0.37	N	0.63	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9625	9625	C	G	MI.7517	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	419	140	S	W	tCa/tGa	7.53	1	0	probably_damaging	1	neutral	0.17	neutral	1.2	deleterious	-10.15	deleterious	-6.82	high_impact	4.79	0.63	neutral	0.03	damaging	4.35	24.10	deleterious	0.03	0.35	0.95	disease	0.89	disease	0.81	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.78	low_impact	-0.2	medium_impact	3.11	high_impact	0.12	0.8	73.56	11.73	0.62	P	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9625	9625	C	T	MI.7518	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	419	140	S	L	tCa/tTa	7.53	1	0	probably_damaging	0.99	neutral	0.75	neutral	1.21	deleterious	-7.42	deleterious	-5.85	high_impact	4.79	0.56	damaging	0.03	damaging	4.63	24.50	deleterious	0.02	0.35	0.78	disease	0.86	disease	0.75	disease	0.7	disease	4	0.99	deleterious	0.38	neutral	2	deleterious	0.86	deleterious	-2.81	low_impact	0.46	medium_impact	3.11	high_impact	0.49	0.8	73.56	11.73	0.7	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9627	9627	G	C	MI.7519	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	421	141	G	R	Gga/Cga	-12.13	0	0	probably_damaging	1	neutral	0.24	neutral	0.9	deleterious	-6.58	deleterious	-7.8	high_impact	4.58	0.6	neutral	0.02	damaging	4.02	23.60	deleterious	0.02	0.35	0.42	neutral	0.82	disease	0.83	disease	0.74	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.09	medium_impact	2.92	high_impact	0.70	0.85	74.33	11.54	0.44	N	0.99	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8879	8879	G	C	MI.752	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	353	118	R	P	cGc/cCc	0.59	0.43	0	probably_damaging	1	neutral	0.2	neutral	4.32	deleterious	-3.37	deleterious	-6.4	high_impact	3.71	0.6	damaging	0.33	neutral	4.21	23.90	deleterious	0.13	0.65	0.81	disease	0.95	disease	0.76	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.6	low_impact	-0.05	medium_impact	2.08	high_impact	0.37	0.9	47.35	8.78	0.38	N	1.00	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9627	9627	G	T	MI.7520	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	421	141	G	W	Gga/Tga	-12.13	0	0	probably_damaging	1	neutral	0.13	neutral	0.88	deleterious	-9.11	deleterious	-7.8	high_impact	4.58	0.58	damaging	0.02	damaging	4.46	24.20	deleterious	0.03	0.35	0.83	disease	0.87	disease	0.78	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.28	medium_impact	2.92	high_impact	0.15	0.8	74.33	11.54	0.4	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9628	9628	G	T	MI.7521	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	422	141	G	V	gGa/gTa	7.3	1	0	probably_damaging	1	neutral	0.48	neutral	0.9	deleterious	-6.37	deleterious	-8.77	high_impact	3.77	0.51	damaging	0.01	damaging	3.79	23.40	deleterious	0.03	0.35	0.38	neutral	0.83	disease	0.76	disease	0.71	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.17	medium_impact	2.2	high_impact	0.17	0.8	74.33	11.54	0.46	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9628	9628	G	C	MI.7522	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	422	141	G	A	gGa/gCa	7.3	1	0	probably_damaging	1	neutral	0.45	neutral	0.95	deleterious	-4.99	deleterious	-5.85	medium_impact	3.48	0.56	damaging	0.01	damaging	3.16	22.60	deleterious	0.08	0.35	0.2	neutral	0.64	disease	0.72	disease	0.67	disease	3	1	deleterious	0.23	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	0.14	medium_impact	1.94	medium_impact	0.49	0.8	74.33	11.54	0.44	N	0.30	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9628	9628	G	A	MI.7523	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	422	141	G	E	gGa/gAa	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	0.91	deleterious	-5.97	deleterious	-7.8	high_impact	4.58	0.49	damaging	0.01	damaging	3.92	23.50	deleterious	0.02	0.35	0.33	neutral	0.85	disease	0.82	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.17	medium_impact	2.92	high_impact	0.24	0.8	74.33	11.54	0.53	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9630	9630	G	A	MI.7524	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	424	142	V	M	Gta/Ata	-3.8	0	0	possibly_damaging	0.72	neutral	0.21	neutral	2.08	neutral	-2.52	neutral	-2.06	medium_impact	2.25	0.62	neutral	0.66	neutral	3.70	23.30	deleterious	0.17	0.45	0.3	neutral	0.53	disease	0.39	neutral	0.36	neutral	3	0.84	neutral	0.25	neutral	0	NA	0.55	deleterious	-1.27	low_impact	-0.14	medium_impact	0.83	medium_impact	0.92	0.95	75.1	11.19	0.41	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	COSM1138440	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9630	9630	G	C	MI.7525	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	424	142	V	L	Gta/Cta	-3.8	0	0	benign	0.04	neutral	0.65	neutral	2.2	neutral	-0.24	neutral	-1.84	low_impact	1.76	0.64	neutral	0.73	neutral	1.85	15.27	deleterious	0.18	0.45	0.11	neutral	0.6	disease	0.37	neutral	0.33	neutral	4	0.3	neutral	0.81	deleterious	-6	neutral	0.16	neutral	0.47	medium_impact	0.35	medium_impact	0.4	medium_impact	0.60	0.8	75.1	11.19	0.34	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9630	9630	G	T	MI.7526	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	424	142	V	L	Gta/Tta	-3.8	0	0	benign	0.04	neutral	0.65	neutral	2.2	neutral	-0.24	neutral	-1.84	low_impact	1.76	0.64	neutral	0.73	neutral	1.97	16.02	deleterious	0.18	0.45	0.11	neutral	0.6	disease	0.37	neutral	0.33	neutral	4	0.3	neutral	0.81	deleterious	-6	neutral	0.16	neutral	0.47	medium_impact	0.35	medium_impact	0.4	medium_impact	0.60	0.8	75.1	11.19	0.34	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9631	9631	T	G	MI.7527	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	425	142	V	G	gTa/gGa	7.53	1	0	possibly_damaging	0.83	neutral	0.48	neutral	2.05	neutral	-2.04	deleterious	-5.7	medium_impact	2.35	0.6	neutral	0.57	neutral	3.83	23.40	deleterious	0.04	0.35	0.32	neutral	0.73	disease	0.6	disease	0.61	disease	2	0.82	neutral	0.33	neutral	0	NA	0.68	deleterious	-1.54	low_impact	0.17	medium_impact	0.92	medium_impact	0.16	0.8	75.1	11.19	0.48	N	0.88	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9631	9631	T	C	MI.7528	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	425	142	V	A	gTa/gCa	7.53	1	0	benign	0.4	neutral	0.61	neutral	2.22	neutral	-1.09	deleterious	-2.74	neutral_impact	0.79	0.71	neutral	0.73	neutral	2.37	18.60	deleterious	0.11	0.4	0.14	neutral	0.23	neutral	0.36	neutral	0.39	neutral	2	0.35	neutral	0.61	deleterious	-6	neutral	0.31	neutral	-0.7	medium_impact	0.3	medium_impact	-0.48	medium_impact	0.22	0.8	75.1	11.19	0.51	P	0.39	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9631	9631	T	A	MI.7529	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	425	142	V	E	gTa/gAa	7.53	1	0	possibly_damaging	0.78	neutral	0.26	neutral	2.06	deleterious	-3.89	deleterious	-4.99	high_impact	3.96	0.6	damaging	0.44	neutral	4.84	24.80	deleterious	0.03	0.35	0.4	neutral	0.87	disease	0.73	disease	0.74	disease	5	0.84	neutral	0.24	neutral	1	deleterious	0.71	deleterious	-1.4	low_impact	-0.07	medium_impact	2.37	high_impact	0.15	0.8	75.1	11.19	0.63	P	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8881	8881	T	C	MI.753	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	355	119	S	P	Tct/Cct	-2.42	0	0	benign	0.21	neutral	0.06	neutral	4.3	neutral	-2.46	neutral	-2.21	low_impact	1.38	0.73	neutral	0.42	neutral	2.12	16.95	deleterious	0.28	0.65	0.79	disease	0.91	disease	0.56	disease	0.73	disease	5	0.93	neutral	0.43	neutral	-6	neutral	0.49	deleterious	-0.21	medium_impact	-0.38	medium_impact	0.09	medium_impact	0.55	0.9	24.34	26.09	0.29	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9633	9633	T	G	MI.7530	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	427	143	S	A	Tca/Gca	-20	0	0	benign	0.04	neutral	0.52	neutral	2.59	neutral	0.68	neutral	-1.28	low_impact	1.58	0.64	neutral	0.57	neutral	1.88	15.45	deleterious	0.28	0.45	0.15	neutral	0.41	neutral	0.48	neutral	0.44	neutral	1	0.44	neutral	0.74	deleterious	-6	neutral	0.17	neutral	0.47	medium_impact	0.21	medium_impact	0.23	medium_impact	0.56	0.8	20.31	43.72	0.39	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9633	9633	T	A	MI.7531	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	427	143	S	T	Tca/Aca	-20	0	0	benign	0	neutral	1	neutral	2.85	neutral	3.14	neutral	2.84	neutral_impact	-1.1	0.73	neutral	0.89	neutral	-0.90	0.03	neutral	0.25	0.45	0.13	neutral	0.07	neutral	0.39	neutral	0.2	neutral	6	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	1.9	high_impact	-2.17	low_impact	0.58	0.8	20.31	43.72	0.36	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9633	9633	T	C	MI.7532	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	427	143	S	P	Tca/Cca	-20	0	0	benign	0.21	neutral	0.1	neutral	2.52	neutral	-1.68	neutral	-2.4	medium_impact	2.27	0.42	damaging	0.33	neutral	3.62	23.20	deleterious	0.05	0.35	0.48	neutral	0.88	disease	0.77	disease	0.76	disease	5	0.88	neutral	0.45	neutral	-3	neutral	0.45	deleterious	-0.31	medium_impact	-0.35	medium_impact	0.85	medium_impact	0.33	0.8	20.31	43.72	0.46	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9634	9634	C	G	MI.7533	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	428	143	S	W	tCa/tGa	3.37	0.99	0	possibly_damaging	0.88	neutral	0.24	neutral	2.5	neutral	-2.71	deleterious	-3.53	medium_impact	2.51	0.54	damaging	0.41	neutral	4.29	24.00	deleterious	0.05	0.35	0.79	disease	0.88	disease	0.7	disease	0.74	disease	5	0.92	neutral	0.18	neutral	0	NA	0.82	deleterious	-1.71	low_impact	-0.09	medium_impact	1.07	medium_impact	0.18	0.8	20.31	43.72	0.42	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9634	9634	C	T	MI.7534	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	428	143	S	L	tCa/tTa	3.37	0.99	0	benign	0.18	neutral	0.43	neutral	2.63	neutral	0.83	deleterious	-2.56	medium_impact	2.42	0.57	damaging	0.41	neutral	3.06	22.40	deleterious	0.08	0.35	0.32	neutral	0.76	disease	0.62	disease	0.71	disease	4	0.49	neutral	0.63	deleterious	-3	neutral	0.30	neutral	-0.23	medium_impact	0.12	medium_impact	0.99	medium_impact	0.40	0.8	20.31	43.72	0.39	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9636	9636	A	C	MI.7535	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	430	144	I	L	Atc/Ctc	-9.82	0	0	probably_damaging	0.95	neutral	0.72	neutral	2.13	neutral	-1.01	neutral	-1.88	low_impact	1.06	0.52	damaging	0.08	damaging	3.56	23.10	deleterious	0.25	0.45	0.17	neutral	0.4	neutral	0.42	neutral	0.44	neutral	1	0.94	neutral	0.39	neutral	-2	neutral	0.39	neutral	-2.11	low_impact	0.43	medium_impact	-0.23	medium_impact	0.48	0.8	75.86	11.24	0.25	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9636	9636	A	T	MI.7536	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	430	144	I	F	Atc/Ttc	-9.82	0	0	probably_damaging	0.99	neutral	0.7	neutral	1.95	deleterious	-3.53	deleterious	-3.83	medium_impact	2.02	0.47	damaging	0.02	damaging	3.89	23.50	deleterious	0.15	0.4	0.35	neutral	0.67	disease	0.66	disease	0.7	disease	4	0.99	deleterious	0.36	neutral	1	deleterious	0.73	deleterious	-2.81	low_impact	0.4	medium_impact	0.63	medium_impact	0.56	0.8	75.86	11.24	0.25	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9636	9636	A	G	MI.7537	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	430	144	I	V	Atc/Gtc	-9.82	0	0	possibly_damaging	0.87	neutral	0.67	neutral	2.51	neutral	0.64	neutral	0.38	neutral_impact	-0.97	0.62	neutral	0.49	neutral	-1.33	0.00	neutral	0.37	0.5	0.11	neutral	0.04	neutral	0.33	neutral	0.18	neutral	6	0.84	neutral	0.4	neutral	-3	neutral	0.42	neutral	-1.67	low_impact	0.37	medium_impact	-2.05	low_impact	0.40	0.8	75.86	11.24	0.31	N	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9637	9637	T	C	MI.7538	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	431	144	I	T	aTc/aCc	2.67	0.99	0	probably_damaging	1	neutral	0.62	neutral	1.96	deleterious	-3.28	deleterious	-3.47	medium_impact	3.29	0.5	damaging	0.03	damaging	3.22	22.70	deleterious	0.06	0.35	0.3	neutral	0.47	neutral	0.62	disease	0.54	disease	1	1	deleterious	0.31	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	0.31	medium_impact	1.77	medium_impact	0.21	0.8	75.86	11.24	0.39	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9637	9637	T	A	MI.7539	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	431	144	I	N	aTc/aAc	2.67	0.99	0	probably_damaging	1	neutral	0.31	neutral	1.93	deleterious	-5.07	deleterious	-6.07	medium_impact	3.29	0.49	damaging	0.02	damaging	4.61	24.40	deleterious	0.06	0.35	0.54	disease	0.74	disease	0.66	disease	0.71	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	-0.01	medium_impact	1.77	medium_impact	0.38	0.8	75.86	11.24	0.39	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8881	8881	T	A	MI.754	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	355	119	S	T	Tct/Act	-2.42	0	0	benign	0.04	neutral	0.17	neutral	4.36	neutral	-0.38	neutral	-0.62	neutral_impact	-0.4	0.92	neutral	0.87	neutral	0.84	9.68	deleterious	0.45	0.65	0.62	disease	0.41	neutral	0.15	neutral	0.61	disease	2	0.82	neutral	0.57	deleterious	-6	neutral	0.24	neutral	0.55	medium_impact	-0.1	medium_impact	-1.44	low_impact	0.83	0.9	24.34	26.09	0.44	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9637	9637	T	G	MI.7540	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	431	144	I	S	aTc/aGc	2.67	0.99	0	probably_damaging	1	neutral	0.43	neutral	1.94	deleterious	-4.06	deleterious	-5.09	medium_impact	2.15	0.47	damaging	0.04	damaging	4.31	24.00	deleterious	0.03	0.35	0.26	neutral	0.71	disease	0.63	disease	0.7	disease	4	1	deleterious	0.22	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	0.12	medium_impact	0.74	medium_impact	0.32	0.8	75.86	11.24	0.34	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9638	9638	C	A	MI.7541	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	432	144	I	M	atC/atA	7.53	1	0	probably_damaging	1	neutral	0.22	neutral	1.96	deleterious	-3.23	neutral	-2.11	low_impact	1.53	0.52	damaging	0.04	damaging	3.80	23.40	deleterious	0.21	0.45	0.17	neutral	0.42	neutral	0.56	disease	0.47	neutral	1	1	deleterious	0.11	neutral	-2	neutral	0.66	deleterious	-3.78	low_impact	-0.12	medium_impact	0.19	medium_impact	0.55	0.8	75.86	11.24	0.5	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9638	9638	C	G	MI.7542	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	432	144	I	M	atC/atG	7.53	1	0	probably_damaging	1	neutral	0.22	neutral	1.96	deleterious	-3.23	neutral	-2.11	low_impact	1.53	0.52	damaging	0.04	damaging	3.38	22.90	deleterious	0.21	0.45	0.17	neutral	0.42	neutral	0.56	disease	0.47	neutral	1	1	deleterious	0.11	neutral	-2	neutral	0.66	deleterious	-3.78	low_impact	-0.12	medium_impact	0.19	medium_impact	0.55	0.8	75.86	11.24	0.5	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9639	9639	A	C	MI.7543	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	433	145	T	P	Acc/Ccc	-9.82	0	0	probably_damaging	0.99	neutral	0.19	neutral	1.54	deleterious	-5.26	deleterious	-5.84	high_impact	4.59	0.67	neutral	0.05	damaging	3.50	23.10	deleterious	0.04	0.35	0.48	neutral	0.79	disease	0.77	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-2.81	low_impact	-0.17	medium_impact	2.93	high_impact	0.45	0.8	73.95	11.6	0.45	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9639	9639	A	T	MI.7544	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	433	145	T	S	Acc/Tcc	-9.82	0	0	probably_damaging	0.96	neutral	0.39	neutral	1.61	deleterious	-3.47	deleterious	-3.88	medium_impact	3.49	0.69	neutral	0.03	damaging	3.32	22.90	deleterious	0.28	0.45	0.25	neutral	0.69	disease	0.57	disease	0.53	disease	1	0.96	neutral	0.22	neutral	1	deleterious	0.71	deleterious	-2.21	low_impact	0.08	medium_impact	1.95	medium_impact	0.66	0.8	73.95	11.6	0.25	N	0.77	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9639	9639	A	G	MI.7545	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	433	145	T	A	Acc/Gcc	-9.82	0	0	probably_damaging	0.96	neutral	0.56	neutral	1.63	deleterious	-3.15	deleterious	-4.86	medium_impact	3.17	0.65	neutral	0.04	damaging	3.55	23.10	deleterious	0.2	0.45	0.16	neutral	0.64	disease	0.64	disease	0.66	disease	3	0.95	neutral	0.3	neutral	1	deleterious	0.67	deleterious	-2.21	low_impact	0.25	medium_impact	1.66	medium_impact	0.53	0.8	73.95	11.6	0.22	N	0.44	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9640	9640	C	G	MI.7546	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	434	145	T	S	aCc/aGc	8.69	1	0	probably_damaging	0.96	neutral	0.39	neutral	1.61	deleterious	-3.47	deleterious	-3.88	medium_impact	3.49	0.69	neutral	0.03	damaging	3.55	23.10	deleterious	0.28	0.45	0.25	neutral	0.69	disease	0.57	disease	0.53	disease	1	0.96	neutral	0.22	neutral	1	deleterious	0.71	deleterious	-2.21	low_impact	0.08	medium_impact	1.95	medium_impact	0.66	0.8	73.95	11.6	0.46	N	0.77	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9640	9640	C	T	MI.7547	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	434	145	T	I	aCc/aTc	8.69	1	0	probably_damaging	1	neutral	0.41	neutral	1.56	deleterious	-4.36	deleterious	-5.84	high_impact	4.04	0.7	neutral	0.02	damaging	4.05	23.70	deleterious	0.06	0.35	0.28	neutral	0.88	disease	0.62	disease	0.69	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.1	medium_impact	2.44	high_impact	0.74	0.85	73.95	11.6	0.44	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9640	9640	C	A	MI.7548	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	434	145	T	N	aCc/aAc	8.69	1	0	probably_damaging	0.99	neutral	0.3	neutral	1.55	deleterious	-4.72	deleterious	-4.86	medium_impact	2.96	0.67	neutral	0.03	damaging	3.75	23.30	deleterious	0.21	0.45	0.33	neutral	0.78	disease	0.67	disease	0.67	disease	3	0.99	deleterious	0.16	neutral	1	deleterious	0.73	deleterious	-2.81	low_impact	-0.02	medium_impact	1.47	medium_impact	0.61	0.8	73.95	11.6	0.41	N	0.89	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9642	9642	T	G	MI.7549	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	436	146	W	G	Tga/Gga	-5.42	0	0	probably_damaging	1	neutral	0.33	neutral	2.18	neutral	-2.55	deleterious	-12.67	high_impact	4.14	0.62	neutral	0.02	damaging	3.99	23.60	deleterious	0.05	0.35	0.38	neutral	0.86	disease	0.73	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.02	medium_impact	2.53	high_impact	0.17	0.8	75.1	11.59	0.4	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8881	8881	T	G	MI.755	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	355	119	S	A	Tct/Gct	-2.42	0	0	benign	0.01	neutral	0.17	neutral	4.36	neutral	-0.09	neutral	-1.59	neutral_impact	0.24	0.87	neutral	0.77	neutral	1.72	14.53	neutral	0.42	0.65	0.53	disease	0.47	neutral	0.27	neutral	0.45	neutral	1	0.83	neutral	0.58	deleterious	-6	neutral	0.22	neutral	1.14	medium_impact	-0.1	medium_impact	-0.89	medium_impact	0.59	0.9	24.34	26.09	0.38	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9642	9642	T	C	MI.7550	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	436	146	W	R	Tga/Cga	-5.42	0	0	probably_damaging	1	neutral	0.35	neutral	2.19	neutral	-2.02	deleterious	-13.64	medium_impact	3.1	0.72	neutral	0.03	damaging	3.60	23.20	deleterious	0.03	0.35	0.34	neutral	0.9	disease	0.78	disease	0.71	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.81	deleterious	-3.78	low_impact	0.04	medium_impact	1.6	medium_impact	0.26	0.8	75.1	11.59	0.38	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9643	9643	G	T	MI.7551	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	437	146	W	L	tGa/tTa	5.91	1	0	probably_damaging	1	neutral	0.66	neutral	2.29	neutral	-0.26	deleterious	-12.67	medium_impact	2.51	0.61	neutral	0.02	damaging	4.35	24.10	deleterious	0.09	0.35	0.11	neutral	0.84	disease	0.71	disease	0.57	disease	1	0.99	deleterious	0.33	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	0.36	medium_impact	1.07	medium_impact	0.17	0.8	75.1	11.59	0.34	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9643	9643	G	C	MI.7552	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	437	146	W	S	tGa/tCa	5.91	1	0	probably_damaging	1	neutral	0.43	neutral	2.21	neutral	-1.48	deleterious	-13.64	high_impact	3.52	0.65	neutral	0.02	damaging	4.07	23.70	deleterious	0.05	0.35	0.24	neutral	0.91	disease	0.71	disease	0.68	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.12	medium_impact	1.97	medium_impact	0.23	0.8	75.1	11.59	0.4	N	0.97	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9644	9644	A	C	MI.7553	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	438	146	W	C	tgA/tgC	9.38	1	0.02	probably_damaging	1	neutral	0.18	neutral	2.17	deleterious	-3.37	deleterious	-12.67	high_impact	3.8	0.67	neutral	0.02	damaging	4.08	23.70	deleterious	0.04	0.35	0.45	neutral	0.9	disease	0.73	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.18	medium_impact	2.22	high_impact	0.21	0.8	75.1	11.59	0.48	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9644	9644	A	T	MI.7554	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	438	146	W	C	tgA/tgT	9.38	1	0.02	probably_damaging	1	neutral	0.18	neutral	2.17	deleterious	-3.37	deleterious	-12.67	high_impact	3.8	0.67	neutral	0.02	damaging	4.19	23.80	deleterious	0.04	0.35	0.45	neutral	0.9	disease	0.73	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.18	medium_impact	2.22	high_impact	0.21	0.8	75.1	11.59	0.49	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9645	9645	G	C	MI.7555	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	439	147	A	P	Gct/Cct	0.59	0.99	0	probably_damaging	1	neutral	0.2	neutral	2	deleterious	-5.48	deleterious	-4.56	high_impact	4.43	0.56	damaging	0.03	damaging	3.85	23.40	deleterious	0.02	0.35	0.7	disease	0.87	disease	0.73	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.15	medium_impact	2.79	high_impact	0.52	0.8	78.16	10.08	0.51	P	0.95	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9645	9645	G	A	MI.7556	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	439	147	A	T	Gct/Act	0.59	0.99	0	probably_damaging	0.99	neutral	0.41	neutral	2.04	deleterious	-3.78	deleterious	-3.47	medium_impact	3.12	0.51	damaging	0.18	damaging	2.26	17.89	deleterious	0.05	0.35	0.48	neutral	0.76	disease	0.53	disease	0.25	neutral	5	0.99	deleterious	0.21	neutral	1	deleterious	0.81	deleterious	-2.81	low_impact	0.1	medium_impact	1.61	medium_impact	0.63	0.8	78.16	10.08	0.45	N	0.78	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9645	9645	G	T	MI.7557	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	439	147	A	S	Gct/Tct	0.59	0.99	0	probably_damaging	0.99	neutral	0.42	neutral	2.12	neutral	-2.46	neutral	-2.31	low_impact	1.3	0.51	damaging	0.19	damaging	2.36	18.58	deleterious	0.08	0.35	0.33	neutral	0.54	disease	0.37	neutral	0.21	neutral	6	0.99	deleterious	0.22	neutral	-2	neutral	0.77	deleterious	-2.81	low_impact	0.11	medium_impact	-0.02	medium_impact	0.53	0.8	78.16	10.08	0.42	N	0.30	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9646	9646	C	T	MI.7558	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	440	147	A	V	gCt/gTt	5.22	1	0	probably_damaging	0.99	neutral	0.5	neutral	2.07	deleterious	-3.89	deleterious	-3.78	high_impact	4.43	0.55	damaging	0.03	damaging	4.07	23.70	deleterious	0.04	0.35	0.45	neutral	0.79	disease	0.61	disease	0.65	disease	3	0.99	deleterious	0.26	neutral	2	deleterious	0.79	deleterious	-2.81	low_impact	0.19	medium_impact	2.79	high_impact	0.65	0.8	78.16	10.08	0.53	P	0.72	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9646	9646	C	A	MI.7559	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	440	147	A	D	gCt/gAt	5.22	1	0	probably_damaging	1	neutral	0.2	neutral	2	deleterious	-4.77	deleterious	-5.33	high_impact	4.43	0.56	damaging	0.02	damaging	4.53	24.30	deleterious	0.02	0.35	0.76	disease	0.9	disease	0.72	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.15	medium_impact	2.79	high_impact	0.35	0.8	78.16	10.08	0.57	P	0.99	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8882	8882	C	G	MI.756	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	356	119	S	C	tCt/tGt	0.36	0	0	benign	0.37	neutral	0.1	neutral	4.31	deleterious	-4.18	neutral	-2.27	low_impact	1.04	0.9	neutral	0.45	neutral	1.87	15.42	deleterious	0.4	0.65	0.93	disease	0.78	disease	0.42	neutral	0.74	disease	5	0.88	neutral	0.37	neutral	-6	neutral	0.56	deleterious	-0.54	medium_impact	-0.25	medium_impact	-0.21	medium_impact	0.61	0.9	24.34	26.09	0.35	N	0.32	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9646	9646	C	G	MI.7560	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	440	147	A	G	gCt/gGt	5.22	1	0	probably_damaging	0.98	neutral	0.33	neutral	2.07	deleterious	-3.18	deleterious	-3.59	low_impact	1.9	0.55	damaging	0.02	damaging	3.60	23.20	deleterious	0.06	0.35	0.34	neutral	0.72	disease	0.53	disease	0.47	neutral	1	0.98	neutral	0.18	neutral	-2	neutral	0.75	deleterious	-2.51	low_impact	0.02	medium_impact	0.52	medium_impact	0.64	0.8	78.16	10.08	0.38	N	0.65	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9648	9648	C	G	MI.7561	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	442	148	H	D	Cac/Gac	-7.51	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.45	deleterious	-4.66	deleterious	-8.77	medium_impact	3.4	0.61	neutral	0.02	damaging	3.92	23.50	deleterious	0.04	0.35	0.35	neutral	0.84	disease	0.79	disease	0.7	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-2.81	low_impact	-0.15	medium_impact	1.86	medium_impact	0.25	0.8	74.33	11.67	0.33	N	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9648	9648	C	T	MI.7562	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	442	148	H	Y	Cac/Tac	-7.51	0	0	probably_damaging	0.98	neutral	1	neutral	1.45	deleterious	-4.71	deleterious	-5.85	high_impact	3.63	0.58	damaging	0.02	damaging	3.81	23.40	deleterious	0.12	0.4	0.38	neutral	0.87	disease	0.74	disease	0.7	disease	4	0.98	deleterious	0.51	deleterious	2	deleterious	0.80	deleterious	-2.51	low_impact	1.9	high_impact	2.07	high_impact	0.14	0.8	74.33	11.67	0.25	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9648	9648	C	A	MI.7563	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	442	148	H	N	Cac/Aac	-7.51	0	0	probably_damaging	0.99	neutral	0.3	neutral	1.44	deleterious	-4.93	deleterious	-6.82	high_impact	4.05	0.55	damaging	0.02	damaging	3.99	23.60	deleterious	0.18	0.45	0.25	neutral	0.82	disease	0.74	disease	0.68	disease	4	0.99	deleterious	0.16	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	-0.02	medium_impact	2.45	high_impact	0.28	0.8	74.33	11.67	0.29	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9649	9649	A	G	MI.7564	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	443	148	H	R	cAc/cGc	7.3	1	0	probably_damaging	0.98	neutral	0.35	neutral	1.46	deleterious	-4.47	deleterious	-7.8	high_impact	4.05	0.7	neutral	0.02	damaging	3.06	22.40	deleterious	0.06	0.35	0.29	neutral	0.82	disease	0.74	disease	0.69	disease	4	0.99	deleterious	0.19	neutral	2	deleterious	0.80	deleterious	-2.51	low_impact	0.04	medium_impact	2.45	high_impact	0.27	0.8	74.33	11.67	0.5	N	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9649	9649	A	T	MI.7565	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	443	148	H	L	cAc/cTc	7.3	1	0	probably_damaging	0.98	neutral	0.67	neutral	1.44	deleterious	-4.8	deleterious	-10.72	medium_impact	2.96	0.57	damaging	0.02	damaging	3.85	23.40	deleterious	0.03	0.35	0.13	neutral	0.87	disease	0.71	disease	0.69	disease	4	0.98	deleterious	0.35	neutral	1	deleterious	0.76	deleterious	-2.51	low_impact	0.37	medium_impact	1.47	medium_impact	0.08	0.8	74.33	11.67	0.33	N	0.96	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9649	9649	A	C	MI.7566	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	443	148	H	P	cAc/cCc	7.3	1	0	probably_damaging	1	neutral	0.2	neutral	1.42	deleterious	-5.91	deleterious	-9.75	high_impact	4.61	0.59	damaging	0.02	damaging	3.25	22.80	deleterious	0.02	0.35	0.45	neutral	0.87	disease	0.83	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.15	medium_impact	2.95	high_impact	0.10	0.8	74.33	11.67	0.54	P	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9650	9650	C	G	MI.7567	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	444	148	H	Q	caC/caG	8.69	1	0.01	probably_damaging	0.99	neutral	0.29	neutral	1.44	deleterious	-4.89	deleterious	-7.8	medium_impact	3.25	0.63	neutral	0.02	damaging	3.60	23.20	deleterious	0.1	0.4	0.29	neutral	0.84	disease	0.67	disease	0.68	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	-0.03	medium_impact	1.73	medium_impact	0.33	0.8	74.33	11.67	0.38	N	0.94	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9650	9650	C	A	MI.7568	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	444	148	H	Q	caC/caA	8.69	1	0.01	probably_damaging	0.99	neutral	0.29	neutral	1.44	deleterious	-4.89	deleterious	-7.8	medium_impact	3.25	0.63	neutral	0.02	damaging	3.95	23.60	deleterious	0.1	0.4	0.29	neutral	0.84	disease	0.67	disease	0.68	disease	4	0.99	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	-0.03	medium_impact	1.73	medium_impact	0.33	0.8	74.33	11.67	0.39	N	0.94	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9651	9651	C	A	MI.7569	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	445	149	H	N	Cat/Aat	-3.11	0	0	benign	0.31	neutral	0.32	neutral	2.21	neutral	-0.97	deleterious	-6.82	medium_impact	2.69	0.52	damaging	0.49	neutral	4.12	23.80	deleterious	0.27	0.45	0.31	neutral	0.77	disease	0.53	disease	0.4	neutral	2	0.61	neutral	0.51	deleterious	-3	neutral	0.45	deleterious	-0.53	medium_impact	0.01	medium_impact	1.23	medium_impact	0.27	0.8	74.33	11.21	0.36	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8882	8882	C	T	MI.757	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	356	119	S	F	tCt/tTt	0.36	0	0	benign	0	neutral	0.25	neutral	4.31	deleterious	-3.14	neutral	-0.46	neutral_impact	-0.28	0.96	neutral	0.93	neutral	0.84	9.69	deleterious	0.32	0.65	0.85	disease	0.82	disease	0.26	neutral	0.54	disease	1	0.75	neutral	0.63	deleterious	-6	neutral	0.33	neutral	2.09	high_impact	0.02	medium_impact	-1.34	low_impact	0.39	0.9	24.34	26.09	0.31	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9651	9651	C	G	MI.7570	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	445	149	H	D	Cat/Gat	-3.11	0	0	benign	0.31	neutral	0.2	neutral	2.2	neutral	-1.51	deleterious	-8.77	high_impact	3.66	0.64	neutral	0.27	damaging	3.89	23.50	deleterious	0.06	0.35	0.33	neutral	0.82	disease	0.67	disease	0.68	disease	4	0.76	neutral	0.45	neutral	-2	neutral	0.46	deleterious	-0.53	medium_impact	-0.15	medium_impact	2.1	high_impact	0.22	0.8	74.33	11.21	0.41	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9651	9651	C	T	MI.7571	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	445	149	H	Y	Cat/Tat	-3.11	0	0	benign	0	neutral	1	neutral	2.21	neutral	-2.44	deleterious	-5.84	medium_impact	1.99	0.59	damaging	0.29	neutral	3.72	23.30	deleterious	0.16	0.45	0.25	neutral	0.78	disease	0.33	neutral	0.35	neutral	3	0	neutral	1	deleterious	-3	neutral	0.25	neutral	2.05	high_impact	1.9	high_impact	0.6	medium_impact	0.12	0.8	74.33	11.21	0.27	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9652	9652	A	G	MI.7572	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	446	149	H	R	cAt/cGt	5.45	1	0	benign	0.12	neutral	0.34	neutral	2.22	neutral	-0.75	deleterious	-7.8	medium_impact	2.69	0.57	damaging	0.2	damaging	3.10	22.50	deleterious	0.1	0.4	0.2	neutral	0.8	disease	0.58	disease	0.65	disease	3	0.61	neutral	0.61	deleterious	-3	neutral	0.44	deleterious	-0.03	medium_impact	0.03	medium_impact	1.23	medium_impact	0.23	0.8	74.33	11.21	0.47	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9652	9652	A	T	MI.7573	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	446	149	H	L	cAt/cTt	5.45	1	0	benign	0.04	neutral	0.77	neutral	2.2	neutral	-1.57	deleterious	-10.72	medium_impact	3.04	0.6	neutral	0.34	neutral	3.98	23.60	deleterious	0.05	0.35	0.23	neutral	0.84	disease	0.59	disease	0.61	disease	2	0.15	neutral	0.87	deleterious	-3	neutral	0.32	neutral	0.47	medium_impact	0.49	medium_impact	1.54	medium_impact	0.09	0.8	74.33	11.21	0.43	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9652	9652	A	C	MI.7574	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	446	149	H	P	cAt/cCt	5.45	1	0	possibly_damaging	0.64	neutral	0.2	neutral	2.16	neutral	-2.67	deleterious	-9.75	high_impact	4.01	0.56	damaging	0.26	damaging	3.31	22.90	deleterious	0.04	0.35	0.46	neutral	0.88	disease	0.69	disease	0.71	disease	4	0.82	neutral	0.28	neutral	1	deleterious	0.72	deleterious	-1.11	low_impact	-0.15	medium_impact	2.41	high_impact	0.12	0.8	74.33	11.21	0.55	P	0.98	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9653	9653	T	G	MI.7575	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	447	149	H	Q	caT/caG	8.69	1	0	benign	0.25	neutral	0.3	neutral	2.21	neutral	-0.71	deleterious	-7.79	medium_impact	3	0.66	neutral	0.31	neutral	3.58	23.20	deleterious	0.13	0.4	0.21	neutral	0.8	disease	0.51	disease	0.51	disease	0	0.64	neutral	0.53	deleterious	-3	neutral	0.44	deleterious	-0.41	medium_impact	-0.02	medium_impact	1.51	medium_impact	0.32	0.8	74.33	11.21	0.54	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9653	9653	T	A	MI.7576	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	447	149	H	Q	caT/caA	8.69	1	0	benign	0.25	neutral	0.3	neutral	2.21	neutral	-0.71	deleterious	-7.79	medium_impact	3	0.66	neutral	0.31	neutral	3.69	23.30	deleterious	0.13	0.4	0.21	neutral	0.8	disease	0.51	disease	0.51	disease	0	0.64	neutral	0.53	deleterious	-3	neutral	0.44	deleterious	-0.41	medium_impact	-0.02	medium_impact	1.51	medium_impact	0.32	0.8	74.33	11.21	0.53	P	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9654	9654	A	G	MI.7577	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	448	150	S	G	Agt/Ggt	-5.19	0	0	probably_damaging	0.97	neutral	0.33	neutral	2.49	neutral	-0.98	deleterious	-2.71	low_impact	1.88	0.62	neutral	0.72	neutral	1.71	14.49	neutral	0.14	0.4	0.35	neutral	0.59	disease	0.23	neutral	0.37	neutral	3	0.98	neutral	0.18	neutral	-2	neutral	0.72	deleterious	-2.34	low_impact	0.02	medium_impact	0.5	medium_impact	0.48	0.8	74.71	11.23	0.41	N	0.83	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9654	9654	A	C	MI.7578	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	448	150	S	R	Agt/Cgt	-5.19	0	0	probably_damaging	1	neutral	0.34	neutral	2.49	neutral	-0.9	deleterious	-3.98	medium_impact	3.19	0.64	neutral	0.43	neutral	3.58	23.20	deleterious	0.04	0.35	0.28	neutral	0.87	disease	0.63	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	0.03	medium_impact	1.68	medium_impact	0.31	0.8	74.71	11.23	0.35	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9654	9654	A	T	MI.7579	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	448	150	S	C	Agt/Tgt	-5.19	0	0	probably_damaging	1	neutral	0.17	neutral	2.47	deleterious	-3.28	deleterious	-3.82	low_impact	1.9	0.67	neutral	0.42	neutral	3.22	22.70	deleterious	0.06	0.35	0.3	neutral	0.82	disease	0.23	neutral	0.59	disease	2	1	deleterious	0.09	neutral	-2	neutral	0.74	deleterious	-3.78	low_impact	-0.2	medium_impact	0.52	medium_impact	0.23	0.8	74.71	11.23	0.38	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8882	8882	C	A	MI.758	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	356	119	S	Y	tCt/tAt	0.36	0	0	benign	0.02	neutral	0.33	neutral	4.33	neutral	-1.9	neutral	0.37	neutral_impact	-0.91	0.93	neutral	0.98	neutral	0.76	9.23	deleterious	0.38	0.65	0.66	disease	0.78	disease	0.23	neutral	0.4	neutral	2	0.65	neutral	0.66	deleterious	-6	neutral	0.29	neutral	0.85	medium_impact	0.12	medium_impact	-1.88	low_impact	0.64	0.9	24.34	26.09	0.29	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9655	9655	G	T	MI.7580	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	449	150	S	I	aGt/aTt	5.68	1	0	probably_damaging	1	neutral	0.43	neutral	2.5	neutral	-2.06	deleterious	-4.75	medium_impact	3.34	0.67	neutral	0.59	neutral	4.08	23.70	deleterious	0.04	0.35	0.18	neutral	0.92	disease	0.49	neutral	0.73	disease	5	1	deleterious	0.22	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.12	medium_impact	1.81	medium_impact	0.33	0.8	74.71	11.23	0.5	P	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9655	9655	G	A	MI.7581	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	449	150	S	N	aGt/aAt	5.68	1	0	probably_damaging	0.92	neutral	0.38	neutral	2.49	neutral	-1.23	deleterious	-2.72	medium_impact	2.73	0.69	neutral	0.51	neutral	1.63	14.04	neutral	0.49	0.55	0.3	neutral	0.74	disease	0.26	neutral	0.48	neutral	0	0.92	neutral	0.23	neutral	1	deleterious	0.73	deleterious	-1.9	low_impact	0.07	medium_impact	1.26	medium_impact	0.26	0.8	74.71	11.23	0.52	P	0.88	polymorphism	1	0.09	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9655	9655	G	C	MI.7582	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	449	150	S	T	aGt/aCt	5.68	1	0	probably_damaging	0.92	neutral	0.45	neutral	2.5	neutral	-1.09	neutral	-2.25	medium_impact	2.73	0.68	neutral	0.69	neutral	1.57	13.71	neutral	0.23	0.45	0.18	neutral	0.74	disease	0.47	neutral	0.52	disease	0	0.92	neutral	0.27	neutral	1	deleterious	0.68	deleterious	-1.9	low_impact	0.14	medium_impact	1.26	medium_impact	0.50	0.8	74.71	11.23	0.51	N	0.63	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9657	9657	C	G	MI.7583	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	451	151	L	V	Cta/Gta	-1.03	0	0	probably_damaging	0.95	neutral	0.62	neutral	2.14	neutral	-1.07	neutral	-1.28	low_impact	1.84	0.49	damaging	0.08	damaging	3.46	23.00	deleterious	0.22	0.45	0.2	neutral	0.64	disease	0.21	neutral	0.33	neutral	3	0.95	neutral	0.34	neutral	-2	neutral	0.69	deleterious	-2.11	low_impact	0.31	medium_impact	0.47	medium_impact	0.41	0.8	74.71	11.38	0.26	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9657	9657	C	A	MI.7584	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	451	151	L	M	Cta/Ata	-1.03	0	0	probably_damaging	1	neutral	0.26	neutral	2.04	neutral	-2.24	neutral	-1	low_impact	1.84	0.55	damaging	0.28	damaging	2.46	19.20	deleterious	0.27	0.45	0.22	neutral	0.49	neutral	0.17	neutral	0.4	neutral	2	1	deleterious	0.13	neutral	-2	neutral	0.70	deleterious	-3.78	low_impact	-0.07	medium_impact	0.47	medium_impact	0.48	0.8	74.71	11.38	0.48	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9658	9658	T	A	MI.7585	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	452	151	L	Q	cTa/cAa	-1.72	0	0	probably_damaging	1	neutral	0.51	neutral	1.99	deleterious	-3.56	deleterious	-5.01	high_impact	3.66	0.47	damaging	0.03	damaging	4.03	23.60	deleterious	0.02	0.35	0.58	disease	0.87	disease	0.5	neutral	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	0.2	medium_impact	2.1	high_impact	0.18	0.8	74.71	11.38	0.26	N	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9658	9658	T	C	MI.7586	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	452	151	L	P	cTa/cCa	-1.72	0	0	probably_damaging	1	neutral	0.3	neutral	1.98	deleterious	-4.34	deleterious	-5.75	high_impact	4	0.39	damaging	0.02	damaging	3.92	23.50	deleterious	0.01	0.35	0.66	disease	0.91	disease	0.66	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.90	deleterious	-3.78	low_impact	-0.02	medium_impact	2.4	high_impact	0.15	0.8	74.71	11.38	0.38	N	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9658	9658	T	G	MI.7587	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	452	151	L	R	cTa/cGa	-1.72	0	0	probably_damaging	1	neutral	0.54	neutral	1.99	deleterious	-3.5	deleterious	-5.13	high_impact	4	0.43	damaging	0.03	damaging	4.16	23.80	deleterious	0.01	0.35	0.57	disease	0.91	disease	0.64	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.89	deleterious	-3.78	low_impact	0.23	medium_impact	2.4	high_impact	0.14	0.8	74.71	11.38	0.3	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9660	9660	A	G	MI.7588	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	454	152	M	V	Ata/Gta	-6.12	0	0	possibly_damaging	0.54	neutral	0.43	neutral	2.4	neutral	0.99	deleterious	-2.65	low_impact	1.75	0.6	damaging	0.66	neutral	0.96	10.45	neutral	0.33	0.5	0.13	neutral	0.65	disease	0.25	neutral	0.24	neutral	5	0.58	neutral	0.45	neutral	-3	neutral	0.36	neutral	-0.94	medium_impact	0.12	medium_impact	0.39	medium_impact	0.29	0.8	75.86	10.9	0.36	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9660	9660	A	T	MI.7589	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	454	152	M	L	Ata/Tta	-6.12	0	0	benign	0.42	neutral	0.58	neutral	2.46	neutral	1.44	neutral	-1.64	neutral_impact	0.4	0.66	neutral	0.74	neutral	0.43	6.89	deleterious	0.24	0.45	0.11	neutral	0.47	neutral	0.17	neutral	0.4	neutral	2	0.39	neutral	0.58	deleterious	-6	neutral	0.28	neutral	-0.73	medium_impact	0.27	medium_impact	-0.82	medium_impact	0.31	0.8	75.86	10.9	0.46	N	0.95	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8884	8884	A	G	MI.759	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	358	120	K	E	Aag/Gag	-4.96	0	0	probably_damaging	0.99	neutral	0.64	neutral	4.29	neutral	-0.76	neutral	-1.86	low_impact	1.87	0.91	neutral	0.44	neutral	4.00	23.60	deleterious	0.4	0.65	0.55	disease	0.86	disease	0.63	disease	0.76	disease	5	0.99	deleterious	0.33	neutral	-2	neutral	0.85	deleterious	-2.65	low_impact	0.43	medium_impact	0.51	medium_impact	0.71	0.9	50.44	8.68	0.22	N	0.85	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9660	9660	A	C	MI.7590	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	454	152	M	L	Ata/Cta	-6.12	0	0	benign	0.42	neutral	0.58	neutral	2.46	neutral	1.44	neutral	-1.64	neutral_impact	0.4	0.66	neutral	0.74	neutral	0.33	5.97	deleterious	0.24	0.45	0.11	neutral	0.47	neutral	0.17	neutral	0.4	neutral	2	0.39	neutral	0.58	deleterious	-6	neutral	0.28	neutral	-0.73	medium_impact	0.27	medium_impact	-0.82	medium_impact	0.31	0.8	75.86	10.9	0.5	N	0.95	polymorphism	1	0.02	.	.	.	.	.	.	.	CPD	0.3	A9660C	LHON	+	-	Reported	1	.	P	P	neutral
chrM	9661	9661	T	C	MI.7591	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	455	152	M	T	aTa/aCa	5.68	1	0	possibly_damaging	0.86	neutral	0.69	neutral	2.34	neutral	0.3	deleterious	-4.62	low_impact	1.78	0.72	neutral	0.74	neutral	1.06	11.01	neutral	0.23	0.45	0.15	neutral	0.8	disease	0.3	neutral	0.25	neutral	5	0.84	neutral	0.42	neutral	-3	neutral	0.62	deleterious	-1.64	low_impact	0.39	medium_impact	0.41	medium_impact	0.06	0.8	75.86	10.9	0.43	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9661	9661	T	A	MI.7592	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	455	152	M	K	aTa/aAa	5.68	1	0	possibly_damaging	0.74	neutral	0.95	neutral	2.29	neutral	-0.61	deleterious	-4.86	low_impact	0.91	0.65	neutral	0.4	neutral	2.44	19.05	deleterious	0.1	0.4	0.11	neutral	0.87	disease	0.55	disease	0.57	disease	1	0.71	neutral	0.61	deleterious	-3	neutral	0.56	deleterious	-1.31	low_impact	0.92	medium_impact	-0.37	medium_impact	0.15	0.8	75.86	10.9	0.39	N	0.99	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9662	9662	A	T	MI.7593	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	456	152	M	I	atA/atT	2.44	1	0	possibly_damaging	0.63	neutral	0.32	neutral	2.46	neutral	1.48	neutral	-2.44	neutral_impact	0.62	0.65	neutral	0.74	neutral	1.60	13.87	neutral	0.29	0.45	0.11	neutral	0.62	disease	0.16	neutral	0.28	neutral	4	0.72	neutral	0.35	neutral	-3	neutral	0.41	neutral	-1.09	low_impact	0.01	medium_impact	-0.63	medium_impact	0.40	0.8	75.86	10.9	0.49	P	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9662	9662	A	C	MI.7594	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	456	152	M	I	atA/atC	2.44	1	0	possibly_damaging	0.63	neutral	0.32	neutral	2.46	neutral	1.48	neutral	-2.44	neutral_impact	0.62	0.65	neutral	0.74	neutral	1.47	13.15	neutral	0.29	0.45	0.11	neutral	0.62	disease	0.16	neutral	0.28	neutral	4	0.72	neutral	0.35	neutral	-3	neutral	0.41	neutral	-1.09	low_impact	0.01	medium_impact	-0.63	medium_impact	0.40	0.8	75.86	10.9	0.48	P	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9663	9663	G	A	MI.7595	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	457	153	E	K	Gaa/Aaa	0.36	0.98	0	benign	0.06	neutral	0.34	neutral	2.28	neutral	0.02	neutral	-2.13	low_impact	0.9	0.66	neutral	0.54	neutral	1.63	14.01	neutral	0.18	0.45	0.16	neutral	0.76	disease	0.25	neutral	0.25	neutral	5	0.63	neutral	0.64	deleterious	-6	neutral	0.21	neutral	0.29	medium_impact	0.03	medium_impact	-0.38	medium_impact	0.43	0.8	26.82	21.02	0.45	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9663	9663	G	C	MI.7596	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	457	153	E	Q	Gaa/Caa	0.36	0.98	0	benign	0.12	neutral	0.32	neutral	2.24	neutral	-0.66	neutral	-1.59	low_impact	1.51	0.73	neutral	0.8	neutral	0.51	7.52	deleterious	0.61	0.65	0.23	neutral	0.55	disease	0.19	neutral	0.24	neutral	5	0.63	neutral	0.6	deleterious	-6	neutral	0.24	neutral	-0.03	medium_impact	0.01	medium_impact	0.17	medium_impact	0.44	0.8	26.82	21.02	0.6	P	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9664	9664	A	G	MI.7597	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	458	153	E	G	gAa/gGa	4.29	1	0.01	benign	0.09	neutral	0.35	neutral	2.19	neutral	-2.36	deleterious	-4.44	low_impact	1.86	0.73	neutral	0.71	neutral	2.31	18.26	deleterious	0.29	0.45	0.36	neutral	0.61	disease	0.41	neutral	0.24	neutral	5	0.61	neutral	0.63	deleterious	-6	neutral	0.24	neutral	0.11	medium_impact	0.04	medium_impact	0.48	medium_impact	0.26	0.8	26.82	21.02	0.55	P	0.89	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9664	9664	A	T	MI.7598	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	458	153	E	V	gAa/gTa	4.29	1	0.01	benign	0.06	neutral	0.51	neutral	2.22	neutral	-2.27	deleterious	-4.61	medium_impact	2	0.67	neutral	0.61	neutral	2.24	17.75	deleterious	0.21	0.45	0.29	neutral	0.74	disease	0.37	neutral	0.25	neutral	5	0.43	neutral	0.73	deleterious	-3	neutral	0.21	neutral	0.29	medium_impact	0.2	medium_impact	0.61	medium_impact	0.49	0.8	26.82	21.02	0.51	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9664	9664	A	C	MI.7599	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	458	153	E	A	gAa/gCa	4.29	1	0.01	benign	0.09	neutral	0.54	neutral	2.3	neutral	-0.53	deleterious	-3.41	neutral_impact	0.63	0.69	neutral	0.76	neutral	0.56	7.86	deleterious	0.34	0.5	0.15	neutral	0.48	neutral	0.25	neutral	0.36	neutral	3	0.38	neutral	0.73	deleterious	-6	neutral	0.17	neutral	0.11	medium_impact	0.23	medium_impact	-0.62	medium_impact	0.48	0.8	26.82	21.02	0.41	N	0.71	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8560	8560	C	A	MI.76	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	34	12	P	T	Ccc/Acc	0.36	0.11	0	probably_damaging	1	neutral	0.11	neutral	4.66	neutral	0.64	deleterious	-6.86	medium_impact	2.12	0.62	neutral	0.07	damaging	3.42	23.00	deleterious	0.44	0.65	0.38	neutral	0.77	disease	0.66	disease	0.55	disease	1	1	deleterious	0.06	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	-0.22	medium_impact	0.72	medium_impact	0.71	0.9	50	8.94	0.3	N	0.93	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8884	8884	A	C	MI.760	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	358	120	K	Q	Aag/Cag	-4.96	0	0	probably_damaging	1	neutral	0.99	neutral	4.28	neutral	-0.89	neutral	-0.83	neutral_impact	-1.02	0.81	neutral	0.63	neutral	0.79	9.40	deleterious	0.6	0.7	0.34	neutral	0.18	neutral	0.19	neutral	0.28	neutral	4	0.99	deleterious	0.5	deleterious	-2	neutral	0.70	deleterious	-3.6	low_impact	1.42	medium_impact	-1.97	low_impact	0.81	0.9	50.44	8.68	0.27	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9665	9665	A	T	MI.7600	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	459	153	E	D	gaA/gaT	4.76	1	0	benign	0.02	neutral	0.24	neutral	2.22	neutral	-1.39	neutral	-1.96	medium_impact	2.65	0.64	neutral	0.6	neutral	1.91	15.66	deleterious	0.62	0.65	0.26	neutral	0.58	disease	0.28	neutral	0.26	neutral	5	0.75	neutral	0.61	deleterious	-3	neutral	0.16	neutral	0.77	medium_impact	-0.09	medium_impact	1.19	medium_impact	0.38	0.8	26.82	21.02	0.64	P	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9665	9665	A	C	MI.7601	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	459	153	E	D	gaA/gaC	4.76	1	0	benign	0.02	neutral	0.24	neutral	2.22	neutral	-1.39	neutral	-1.96	medium_impact	2.65	0.64	neutral	0.6	neutral	1.78	14.86	neutral	0.62	0.65	0.26	neutral	0.58	disease	0.28	neutral	0.26	neutral	5	0.75	neutral	0.61	deleterious	-3	neutral	0.16	neutral	0.77	medium_impact	-0.09	medium_impact	1.19	medium_impact	0.38	0.8	26.82	21.02	0.64	P	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9666	9666	A	T	MI.7602	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	460	154	N	Y	Aac/Tac	0.59	0.98	0	possibly_damaging	0.8	neutral	1	neutral	2.41	deleterious	-3.46	deleterious	-4.17	medium_impact	2.24	0.68	neutral	0.63	neutral	3.45	23.00	deleterious	0.16	0.45	0.39	neutral	0.79	disease	0.55	disease	0.7	disease	4	0.8	neutral	0.6	deleterious	0	NA	0.65	deleterious	-1.45	low_impact	1.9	high_impact	0.83	medium_impact	0.20	0.8	19.92	56.92	0.35	N	0.90	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9666	9666	A	C	MI.7603	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	460	154	N	H	Aac/Cac	0.59	0.98	0	possibly_damaging	0.8	neutral	0.59	neutral	2.43	neutral	-2.39	deleterious	-2.67	low_impact	1.44	0.73	neutral	0.63	neutral	2.88	21.80	deleterious	0.59	0.65	0.23	neutral	0.65	disease	0.56	disease	0.68	disease	4	0.76	neutral	0.4	neutral	-3	neutral	0.59	deleterious	-1.45	low_impact	0.28	medium_impact	0.11	medium_impact	0.17	0.8	19.92	56.92	0.36	N	0.43	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9666	9666	A	G	MI.7604	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	460	154	N	D	Aac/Gac	0.59	0.98	0	benign	0.24	neutral	0.32	neutral	2.53	neutral	-0.54	neutral	-2.09	low_impact	1.38	0.66	neutral	0.68	neutral	1.98	16.11	deleterious	0.72	0.75	0.14	neutral	0.63	disease	0.34	neutral	0.34	neutral	3	0.61	neutral	0.54	deleterious	-6	neutral	0.24	neutral	-0.38	medium_impact	0.01	medium_impact	0.05	medium_impact	0.32	0.8	19.92	56.92	0.49	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9667	9667	A	G	MI.7605	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	461	154	N	S	aAc/aGc	1.52	0.98	0.01	benign	0.14	neutral	0.57	neutral	2.5	neutral	-0.86	neutral	-0.9	low_impact	0.86	0.74	neutral	0.81	neutral	-0.06	2.02	deleterious	0.74	0.8	0.13	neutral	0.48	neutral	0.3	neutral	0.41	neutral	2	0.33	neutral	0.72	deleterious	-6	neutral	0.19	neutral	-0.1	medium_impact	0.26	medium_impact	-0.41	medium_impact	0.41	0.8	19.92	56.92	0.46	N	0.21	polymorphism	1	0.02	rs41482146	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9667	9667	A	C	MI.7606	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	461	154	N	T	aAc/aCc	1.52	0.98	0.01	benign	0.34	neutral	0.49	neutral	2.44	neutral	-1.89	deleterious	-2.55	medium_impact	2.44	0.65	neutral	0.82	neutral	1.58	13.74	neutral	0.45	0.55	0.17	neutral	0.68	disease	0.51	disease	0.5	neutral	0	0.43	neutral	0.58	deleterious	-3	neutral	0.31	neutral	-0.59	medium_impact	0.18	medium_impact	1	medium_impact	0.24	0.8	19.92	56.92	0.5	N	0.43	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9667	9667	A	T	MI.7607	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	461	154	N	I	aAc/aTc	1.52	0.98	0.01	possibly_damaging	0.73	neutral	0.42	neutral	2.4	deleterious	-4.86	deleterious	-4.88	medium_impact	3.13	0.71	neutral	0.67	neutral	3.58	23.20	deleterious	0.14	0.4	0.34	neutral	0.85	disease	0.51	disease	0.72	disease	4	0.73	neutral	0.35	neutral	0	NA	0.61	deleterious	-1.29	low_impact	0.11	medium_impact	1.62	medium_impact	0.16	0.8	19.92	56.92	0.48	N	0.90	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9668	9668	C	G	MI.7608	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	462	154	N	K	aaC/aaG	1.52	0.95	0	benign	0.34	neutral	0.5	neutral	2.49	neutral	-0.93	deleterious	-2.56	low_impact	1.19	0.69	neutral	0.72	neutral	0.98	10.52	neutral	0.6	0.65	0.12	neutral	0.66	disease	0.33	neutral	0.33	neutral	3	0.41	neutral	0.58	deleterious	-6	neutral	0.31	neutral	-0.59	medium_impact	0.19	medium_impact	-0.12	medium_impact	0.35	0.8	19.92	56.92	0.38	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9668	9668	C	A	MI.7609	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	462	154	N	K	aaC/aaA	1.52	0.95	0	benign	0.34	neutral	0.5	neutral	2.49	neutral	-0.93	deleterious	-2.56	low_impact	1.19	0.69	neutral	0.72	neutral	1.43	12.97	neutral	0.6	0.65	0.12	neutral	0.66	disease	0.33	neutral	0.33	neutral	3	0.41	neutral	0.58	deleterious	-6	neutral	0.31	neutral	-0.59	medium_impact	0.19	medium_impact	-0.12	medium_impact	0.35	0.8	19.92	56.92	0.38	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8885	8885	A	T	MI.761	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	359	120	K	M	aAg/aTg	3.14	0.99	0	probably_damaging	1	neutral	0.18	neutral	4.16	deleterious	-3.94	deleterious	-3.71	low_impact	1.76	0.9	neutral	0.57	neutral	4.03	23.60	deleterious	0.28	0.65	0.86	disease	0.72	disease	0.49	neutral	0.61	disease	2	1	deleterious	0.09	neutral	-2	neutral	0.84	deleterious	-3.6	low_impact	-0.08	medium_impact	0.41	medium_impact	0.49	0.9	50.44	8.68	0.51	N	0.53	polymorphism	0.8	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9669	9669	A	C	MI.7610	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	463	155	N	H	Aac/Cac	-20	0	0	possibly_damaging	0.65	neutral	0.52	neutral	2.34	neutral	-2.85	deleterious	-3.11	medium_impact	2.52	0.77	neutral	0.95	neutral	1.77	14.83	neutral	0.73	0.75	0.41	neutral	0.78	disease	0.47	neutral	0.33	neutral	3	0.62	neutral	0.44	neutral	0	NA	0.48	deleterious	-1.13	low_impact	0.21	medium_impact	1.08	medium_impact	0.15	0.8	18.39	17.31	0.31	N	0.39	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9669	9669	A	G	MI.7611	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	463	155	N	D	Aac/Gac	-20	0	0	benign	0.01	neutral	0.54	neutral	2.46	neutral	-0.92	deleterious	-2.61	neutral_impact	0.68	0.8	neutral	0.99	neutral	0.49	7.38	deleterious	0.82	0.85	0.14	neutral	0.54	disease	0.28	neutral	0.23	neutral	5	0.45	neutral	0.77	deleterious	-6	neutral	0.11	neutral	1.07	medium_impact	0.23	medium_impact	-0.57	medium_impact	0.28	0.8	18.39	17.31	0.35	N	0.01	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9669	9669	A	T	MI.7612	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	463	155	N	Y	Aac/Tac	-20	0	0	possibly_damaging	0.65	neutral	0.58	neutral	2.32	deleterious	-3.83	deleterious	-5.41	medium_impact	2.46	0.73	neutral	0.54	neutral	3.39	23.00	deleterious	0.19	0.45	0.55	disease	0.87	disease	0.56	disease	0.6	disease	2	0.6	neutral	0.47	neutral	0	NA	0.60	deleterious	-1.13	low_impact	0.27	medium_impact	1.02	medium_impact	0.19	0.8	18.39	17.31	0.25	N	0.80	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9670	9670	A	G	MI.7613	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	464	155	N	S	aAc/aGc	-0.33	0	0	benign	0.01	neutral	0.94	neutral	2.42	neutral	-1.33	deleterious	-2.82	medium_impact	2.26	0.76	neutral	0.95	neutral	0.60	8.13	deleterious	0.8	0.85	0.18	neutral	0.69	disease	0.29	neutral	0.24	neutral	5	0.03	neutral	0.97	deleterious	-3	neutral	0.15	neutral	1.07	medium_impact	0.87	medium_impact	0.84	medium_impact	0.33	0.8	18.39	17.31	0.3	N	0.01	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9670	9670	A	T	MI.7614	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	464	155	N	I	aAc/aTc	-0.33	0	0	possibly_damaging	0.5	neutral	0.36	neutral	2.31	deleterious	-4.35	deleterious	-6.26	high_impact	3.96	0.73	neutral	0.53	neutral	4.23	23.90	deleterious	0.19	0.45	0.51	disease	0.92	disease	0.49	neutral	0.69	disease	4	0.61	neutral	0.43	neutral	1	deleterious	0.47	deleterious	-0.87	medium_impact	0.05	medium_impact	2.37	high_impact	0.17	0.8	18.39	17.31	0.41	N	0.78	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9670	9670	A	C	MI.7615	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	464	155	N	T	aAc/aCc	-0.33	0	0	benign	0.1	neutral	0.6	neutral	2.35	neutral	-2.56	deleterious	-3.77	medium_impact	3.41	0.71	neutral	0.63	neutral	2.10	16.86	deleterious	0.55	0.6	0.27	neutral	0.83	disease	0.41	neutral	0.65	disease	3	0.31	neutral	0.75	deleterious	-3	neutral	0.20	neutral	0.06	medium_impact	0.29	medium_impact	1.87	medium_impact	0.17	0.8	18.39	17.31	0.35	N	0.15	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9671	9671	C	A	MI.7616	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	465	155	N	K	aaC/aaA	3.83	0.09	0	benign	0.1	neutral	0.9	neutral	2.42	neutral	-1.33	deleterious	-3.37	low_impact	1.41	0.68	neutral	0.75	neutral	1.27	12.09	neutral	0.67	0.7	0.13	neutral	0.74	disease	0.31	neutral	0.25	neutral	5	0.04	neutral	0.9	deleterious	-6	neutral	0.19	neutral	0.06	medium_impact	0.74	medium_impact	0.08	medium_impact	0.51	0.8	18.39	17.31	0.35	N	0.15	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9671	9671	C	G	MI.7617	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	465	155	N	K	aaC/aaG	3.83	0.09	0	benign	0.1	neutral	0.9	neutral	2.42	neutral	-1.33	deleterious	-3.37	low_impact	1.41	0.68	neutral	0.75	neutral	0.85	9.79	deleterious	0.67	0.7	0.13	neutral	0.74	disease	0.31	neutral	0.25	neutral	5	0.04	neutral	0.9	deleterious	-6	neutral	0.19	neutral	0.06	medium_impact	0.74	medium_impact	0.08	medium_impact	0.51	0.8	18.39	17.31	0.35	N	0.15	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9672	9672	C	G	MI.7618	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	466	156	R	G	Cga/Gga	-3.57	0	0	probably_damaging	1	neutral	0.54	neutral	2.16	deleterious	-3.14	deleterious	-4	medium_impact	2.25	0.53	damaging	0.06	damaging	4.13	23.80	deleterious	0.08	0.35	0.32	neutral	0.71	disease	0.53	disease	0.56	disease	1	1	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	0.23	medium_impact	0.83	medium_impact	0.24	0.8	76.25	10.2	0.2	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9672	9672	C	T	MI.7619	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	466	156	R	W	Cga/Tga	-3.57	0	0	probably_damaging	1	neutral	0.12	neutral	2.12	deleterious	-6.05	deleterious	-3.69	low_impact	1.8	0.55	damaging	0.02	damaging	5.17	25.50	deleterious	0.09	0.35	0.73	disease	0.84	disease	0.33	neutral	0.55	disease	1	1	deleterious	0.06	neutral	-2	neutral	0.79	deleterious	-3.78	low_impact	-0.3	medium_impact	0.43	medium_impact	0.55	0.8	76.25	10.2	0.25	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8885	8885	A	C	MI.762	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	359	120	K	T	aAg/aCg	3.14	0.99	0	probably_damaging	0.99	neutral	0.44	neutral	4.21	neutral	-2.01	deleterious	-3.98	low_impact	1.76	0.87	neutral	0.51	neutral	3.74	23.30	deleterious	0.33	0.65	0.66	disease	0.67	disease	0.59	disease	0.69	disease	4	0.99	deleterious	0.23	neutral	-2	neutral	0.82	deleterious	-2.65	low_impact	0.23	medium_impact	0.41	medium_impact	0.71	0.9	50.44	8.68	0.4	N	0.81	polymorphism	0.9	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9673	9673	G	C	MI.7620	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	467	156	R	P	cGa/cCa	3.6	0.97	0	probably_damaging	1	neutral	0.21	neutral	2.14	deleterious	-3.44	deleterious	-4	medium_impact	2.59	0.45	damaging	0.02	damaging	4.23	23.90	deleterious	0.03	0.35	0.3	neutral	0.92	disease	0.49	neutral	0.71	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	-0.14	medium_impact	1.14	medium_impact	0.17	0.8	76.25	10.2	0.43	N	0.99	polymorphism	1	0.10	rs28463067	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9673	9673	G	T	MI.7621	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	467	156	R	L	cGa/cTa	3.6	0.97	0	probably_damaging	0.99	neutral	0.6	neutral	2.18	neutral	-2.56	deleterious	-3.54	low_impact	1.37	0.53	damaging	0.03	damaging	4.01	23.60	deleterious	0.11	0.4	0.24	neutral	0.84	disease	0.44	neutral	0.5	disease	0	0.99	deleterious	0.31	neutral	-2	neutral	0.73	deleterious	-2.81	low_impact	0.29	medium_impact	0.05	medium_impact	0.03	0.8	76.25	10.2	0.33	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9673	9673	G	A	MI.7622	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	467	156	R	Q	cGa/cAa	3.6	0.97	0	probably_damaging	0.99	neutral	0.41	neutral	2.21	neutral	-1.96	neutral	-1.75	low_impact	1.9	0.56	damaging	0.06	damaging	2.57	19.89	deleterious	0.37	0.5	0.18	neutral	0.72	disease	0.33	neutral	0.48	neutral	0	0.99	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-2.81	low_impact	0.1	medium_impact	0.52	medium_impact	0.80	0.85	76.25	10.2	0.38	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9675	9675	A	C	MI.7623	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	469	157	N	H	Aac/Cac	-1.26	0	0	benign	0.34	neutral	0.56	neutral	2.25	neutral	-1.27	neutral	-1.38	low_impact	1.21	0.7	neutral	0.17	damaging	1.56	13.65	neutral	0.66	0.7	0.34	neutral	0.49	neutral	0.46	neutral	0.51	disease	0	0.36	neutral	0.61	deleterious	-6	neutral	0.23	neutral	-0.59	medium_impact	0.25	medium_impact	-0.1	medium_impact	0.15	0.8	16.86	15.28	0.24	N	0.37	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9675	9675	A	G	MI.7624	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	469	157	N	D	Aac/Gac	-1.26	0	0	benign	0.03	neutral	0.25	neutral	2.29	neutral	-0.17	neutral	-1.09	low_impact	0.88	0.65	neutral	0.16	damaging	2.04	16.45	deleterious	0.73	0.75	0.19	neutral	0.48	neutral	0.34	neutral	0.43	neutral	1	0.74	neutral	0.61	deleterious	-6	neutral	0.13	neutral	0.6	medium_impact	-0.08	medium_impact	-0.39	medium_impact	0.48	0.8	16.86	15.28	0.39	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9675	9675	A	T	MI.7625	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	469	157	N	Y	Aac/Tac	-1.26	0	0	benign	0.19	neutral	1	neutral	2.24	neutral	-1.79	neutral	-2.26	low_impact	0.8	0.72	neutral	0.82	neutral	2.07	16.69	deleterious	0.21	0.45	0.47	neutral	0.61	disease	0.35	neutral	0.48	neutral	0	0.19	neutral	0.91	deleterious	-6	neutral	0.28	neutral	-0.26	medium_impact	1.9	high_impact	-0.47	medium_impact	0.37	0.8	16.86	15.28	0.24	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9676	9676	A	G	MI.7626	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	470	157	N	S	aAc/aGc	5.68	0.69	0	benign	0.02	neutral	0.48	neutral	2.33	neutral	0.75	neutral	0.63	neutral_impact	0.02	0.77	neutral	0.79	neutral	-0.24	0.92	neutral	0.71	0.75	0.13	neutral	0.24	neutral	0.21	neutral	0.42	neutral	2	0.5	neutral	0.73	deleterious	-6	neutral	0.10	neutral	0.77	medium_impact	0.17	medium_impact	-1.17	low_impact	0.31	0.8	16.86	15.28	0.41	N	0.22	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9676	9676	A	T	MI.7627	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	470	157	N	I	aAc/aTc	5.68	0.69	0	benign	0.05	neutral	0.4	neutral	2.25	neutral	-1.81	deleterious	-2.51	low_impact	1.07	0.75	neutral	0.46	neutral	1.92	15.73	deleterious	0.22	0.45	0.42	neutral	0.71	disease	0.39	neutral	0.53	disease	1	0.56	neutral	0.68	deleterious	-6	neutral	0.19	neutral	0.37	medium_impact	0.09	medium_impact	-0.22	medium_impact	0.33	0.8	16.86	15.28	0.39	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9676	9676	A	C	MI.7628	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	470	157	N	T	aAc/aCc	5.68	0.69	0	benign	0	neutral	0.43	neutral	2.3	neutral	0.07	neutral	0.06	neutral_impact	0.24	0.68	neutral	0.46	neutral	0.16	4.22	deleterious	0.53	0.6	0.22	neutral	0.34	neutral	0.18	neutral	0.44	neutral	1	0.57	neutral	0.72	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.12	medium_impact	-0.97	medium_impact	0.29	0.8	16.86	15.28	0.5	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9677	9677	C	A	MI.7629	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	471	157	N	K	aaC/aaA	0.82	0.14	0	benign	0	neutral	0.42	neutral	2.42	neutral	1.51	neutral	1.27	neutral_impact	-1.32	0.77	neutral	0.95	neutral	-0.16	1.33	neutral	0.59	0.65	0.16	neutral	0.19	neutral	0.19	neutral	0.37	neutral	3	0.58	neutral	0.71	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	0.11	medium_impact	-2.37	low_impact	0.57	0.8	16.86	15.28	0.43	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8886	8886	G	C	MI.763	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	360	120	K	N	aaG/aaC	8.69	1	0	probably_damaging	1	neutral	0.81	neutral	4.25	neutral	-1.29	deleterious	-2.98	neutral_impact	0.2	0.89	neutral	0.47	neutral	3.92	23.50	deleterious	0.6	0.7	0.44	neutral	0.59	disease	0.31	neutral	0.4	neutral	2	0.99	deleterious	0.41	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.65	medium_impact	-0.93	medium_impact	0.76	0.9	50.44	8.68	0.42	N	0.76	disease_causing	0.68	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9677	9677	C	G	MI.7630	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	471	157	N	K	aaC/aaG	0.82	0.14	0	benign	0	neutral	0.42	neutral	2.42	neutral	1.51	neutral	1.27	neutral_impact	-1.32	0.77	neutral	0.95	neutral	-0.60	0.13	neutral	0.59	0.65	0.16	neutral	0.19	neutral	0.19	neutral	0.37	neutral	3	0.58	neutral	0.71	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	0.11	medium_impact	-2.37	low_impact	0.57	0.8	16.86	15.28	0.43	N	0.07	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9678	9678	C	G	MI.7631	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	472	158	Q	E	Caa/Gaa	-1.03	0	0	benign	0	neutral	0.97	neutral	2.34	neutral	0.19	neutral	0.04	neutral_impact	-0.4	0.68	neutral	0.52	neutral	-0.96	0.02	neutral	0.34	0.5	0.11	neutral	0.4	neutral	0.17	neutral	0.44	neutral	1	0.02	neutral	0.99	deleterious	-6	neutral	0.14	neutral	2.05	high_impact	1.05	medium_impact	-1.54	low_impact	0.43	0.8	22.22	41.6	0.38	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9678	9678	C	A	MI.7632	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	472	158	Q	K	Caa/Aaa	-1.03	0	0	benign	0.08	neutral	0.89	neutral	2.34	neutral	0.2	neutral	-1.68	neutral_impact	0.12	0.66	neutral	0.27	damaging	1.41	12.85	neutral	0.25	0.45	0.13	neutral	0.78	disease	0.31	neutral	0.52	disease	0	0.03	neutral	0.91	deleterious	-6	neutral	0.20	neutral	0.16	medium_impact	0.71	medium_impact	-1.08	low_impact	0.43	0.8	22.22	41.6	0.22	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9679	9679	A	T	MI.7633	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	473	158	Q	L	cAa/cTa	-0.1	0	0	benign	0.16	neutral	0.79	neutral	2.25	neutral	-1.06	deleterious	-4.88	low_impact	1.39	0.63	neutral	0.18	damaging	3.55	23.10	deleterious	0.13	0.4	0.28	neutral	0.77	disease	0.33	neutral	0.58	disease	2	0.11	neutral	0.82	deleterious	-6	neutral	0.27	neutral	-0.17	medium_impact	0.52	medium_impact	0.06	medium_impact	0.14	0.8	22.22	41.6	0.22	N	0.74	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9679	9679	A	C	MI.7634	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	473	158	Q	P	cAa/cCa	-0.1	0	0	benign	0.2	neutral	0.35	neutral	2.22	neutral	-2.1	deleterious	-3.49	low_impact	1.55	0.74	neutral	0.91	neutral	2.20	17.48	deleterious	0.07	0.35	0.35	neutral	0.88	disease	0.5	neutral	0.54	disease	1	0.58	neutral	0.58	deleterious	-6	neutral	0.40	neutral	-0.28	medium_impact	0.04	medium_impact	0.21	medium_impact	0.28	0.8	22.22	41.6	0.36	N	0.90	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9679	9679	A	G	MI.7635	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	473	158	Q	R	cAa/cGa	-0.1	0	0	benign	0.08	neutral	0.64	neutral	2.28	neutral	-0.49	neutral	-2.19	low_impact	0.82	0.61	neutral	0.15	damaging	3.13	22.60	deleterious	0.34	0.5	0.15	neutral	0.75	disease	0.38	neutral	0.57	disease	1	0.27	neutral	0.78	deleterious	-6	neutral	0.23	neutral	0.16	medium_impact	0.33	medium_impact	-0.45	medium_impact	0.20	0.8	22.22	41.6	0.22	N	0.33	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9680	9680	A	T	MI.7636	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	474	158	Q	H	caA/caT	4.76	0.31	0.01	possibly_damaging	0.57	neutral	0.6	neutral	2.24	neutral	-1.34	neutral	-2.36	low_impact	1.32	0.74	neutral	0.96	neutral	2.20	17.51	deleterious	0.21	0.45	0.23	neutral	0.6	disease	0.28	neutral	0.45	neutral	1	0.51	neutral	0.52	deleterious	-3	neutral	0.47	deleterious	-0.99	medium_impact	0.29	medium_impact	0	medium_impact	0.46	0.8	22.22	41.6	0.37	N	0.08	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9680	9680	A	C	MI.7637	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	474	158	Q	H	caA/caC	4.76	0.31	0.01	possibly_damaging	0.57	neutral	0.6	neutral	2.24	neutral	-1.34	neutral	-2.36	low_impact	1.32	0.74	neutral	0.96	neutral	2.03	16.41	deleterious	0.21	0.45	0.23	neutral	0.6	disease	0.28	neutral	0.45	neutral	1	0.51	neutral	0.52	deleterious	-3	neutral	0.47	deleterious	-0.99	medium_impact	0.29	medium_impact	0	medium_impact	0.46	0.8	22.22	41.6	0.36	N	0.08	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9681	9681	A	T	MI.7638	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	475	159	M	L	Ata/Tta	-1.72	0	0	benign	0.02	neutral	0.97	neutral	2.69	neutral	1.29	neutral	-0.57	neutral_impact	-0.68	0.67	neutral	0.5	neutral	1.41	12.83	neutral	0.26	0.45	0.1	neutral	0.49	neutral	0.41	neutral	0.42	neutral	2	0	neutral	0.98	deleterious	-6	neutral	0.16	neutral	0.77	medium_impact	1.05	medium_impact	-1.79	low_impact	0.40	0.8	22.22	41.39	0.3	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9681	9681	A	G	MI.7639	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	475	159	M	V	Ata/Gta	-1.72	0	0	benign	0.02	neutral	0.67	neutral	2.69	neutral	0.6	neutral	-0.02	neutral_impact	0	0.8	neutral	0.73	neutral	0.74	9.06	deleterious	0.26	0.45	0.1	neutral	0.49	neutral	0.37	neutral	0.42	neutral	2	0.29	neutral	0.83	deleterious	-6	neutral	0.16	neutral	0.77	medium_impact	0.37	medium_impact	-1.18	low_impact	0.42	0.8	22.22	41.39	0.21	N	0.87	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8886	8886	G	T	MI.764	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	360	120	K	N	aaG/aaT	8.69	1	0	probably_damaging	1	neutral	0.81	neutral	4.25	neutral	-1.29	deleterious	-2.98	neutral_impact	0.2	0.89	neutral	0.47	neutral	4.05	23.70	deleterious	0.6	0.7	0.44	neutral	0.59	disease	0.31	neutral	0.4	neutral	2	0.99	deleterious	0.41	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.65	medium_impact	-0.93	medium_impact	0.76	0.9	50.44	8.68	0.43	N	0.76	disease_causing	0.68	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9681	9681	A	C	MI.7640	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	475	159	M	L	Ata/Cta	-1.72	0	0	benign	0.02	neutral	0.97	neutral	2.69	neutral	1.29	neutral	-0.57	neutral_impact	-0.68	0.67	neutral	0.5	neutral	1.31	12.31	neutral	0.26	0.45	0.1	neutral	0.49	neutral	0.41	neutral	0.42	neutral	2	0	neutral	0.98	deleterious	-6	neutral	0.16	neutral	0.77	medium_impact	1.05	medium_impact	-1.79	low_impact	0.40	0.8	22.22	41.39	0.3	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9682	9682	T	C	MI.7641	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	476	159	M	T	aTa/aCa	1.52	0.21	0	benign	0	neutral	0.65	neutral	2.65	neutral	0.29	neutral	1.17	neutral_impact	-0.94	0.78	neutral	0.8	neutral	-0.42	0.36	neutral	0.13	0.4	0.19	neutral	0.34	neutral	0.34	neutral	0.43	neutral	1	0.34	neutral	0.83	deleterious	-6	neutral	0.14	neutral	2.05	high_impact	0.35	medium_impact	-2.03	low_impact	0.17	0.8	22.22	41.39	0.23	N	0.51	polymorphism	1	0.00	rs199750417	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9682	9682	T	A	MI.7642	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	476	159	M	K	aTa/aAa	1.52	0.21	0	benign	0.05	neutral	0.47	neutral	2.56	neutral	-2.13	neutral	-0.88	low_impact	1.25	0.58	damaging	0.41	neutral	2.34	18.45	deleterious	0.03	0.35	0.3	neutral	0.8	disease	0.48	neutral	0.66	disease	3	0.48	neutral	0.71	deleterious	-6	neutral	0.26	neutral	0.37	medium_impact	0.16	medium_impact	-0.06	medium_impact	0.21	0.8	22.22	41.39	0.34	N	0.95	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9683	9683	A	C	MI.7643	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	477	159	M	I	atA/atC	2.21	0.22	0	benign	0.05	neutral	0.52	neutral	2.6	neutral	-0.26	neutral	-0.71	low_impact	1.02	0.67	neutral	0.56	neutral	1.64	14.09	neutral	0.21	0.45	0.16	neutral	0.59	disease	0.35	neutral	0.48	neutral	0	0.43	neutral	0.74	deleterious	-6	neutral	0.20	neutral	0.37	medium_impact	0.21	medium_impact	-0.27	medium_impact	0.40	0.8	22.22	41.39	0.36	N	0.80	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9683	9683	A	T	MI.7644	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	477	159	M	I	atA/atT	2.21	0.22	0	benign	0.05	neutral	0.52	neutral	2.6	neutral	-0.26	neutral	-0.71	low_impact	1.02	0.67	neutral	0.56	neutral	1.70	14.42	neutral	0.21	0.45	0.16	neutral	0.59	disease	0.35	neutral	0.48	neutral	0	0.43	neutral	0.74	deleterious	-6	neutral	0.20	neutral	0.37	medium_impact	0.21	medium_impact	-0.27	medium_impact	0.40	0.8	22.22	41.39	0.36	N	0.80	disease_causing	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9684	9684	A	T	MI.7645	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	478	160	I	F	Att/Ttt	-1.03	0	0	benign	0.28	neutral	0.64	neutral	2.19	neutral	-1.47	neutral	-2.02	low_impact	1.22	0.68	neutral	0.59	neutral	3.38	22.90	deleterious	0.21	0.45	0.32	neutral	0.64	disease	0.42	neutral	0.48	neutral	0	0.26	neutral	0.68	deleterious	-6	neutral	0.38	neutral	-0.47	medium_impact	0.33	medium_impact	-0.09	medium_impact	0.54	0.8	26.05	51.21	0.28	N	0.64	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9684	9684	A	G	MI.7646	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	478	160	I	V	Att/Gtt	-1.03	0	0	benign	0.03	neutral	0.55	neutral	2.31	neutral	-0.1	neutral	-0.19	low_impact	1.28	0.71	neutral	0.73	neutral	0.09	3.50	deleterious	0.55	0.6	0.12	neutral	0.23	neutral	0.28	neutral	0.41	neutral	2	0.41	neutral	0.76	deleterious	-6	neutral	0.10	neutral	0.6	medium_impact	0.24	medium_impact	-0.04	medium_impact	0.59	0.8	26.05	51.21	0.34	N	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9684	9684	A	C	MI.7647	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	478	160	I	L	Att/Ctt	-1.03	0	0	benign	0.03	neutral	1	neutral	2.38	neutral	0.37	neutral	-0.62	neutral_impact	0.15	0.78	neutral	0.94	neutral	0.39	6.52	deleterious	0.26	0.45	0.12	neutral	0.38	neutral	0.22	neutral	0.43	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.10	neutral	0.6	medium_impact	1.9	high_impact	-1.05	low_impact	0.52	0.8	26.05	51.21	0.29	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9685	9685	T	G	MI.7648	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	479	160	I	S	aTt/aGt	0.13	0	0	benign	0.05	neutral	0.81	neutral	2.18	neutral	-1.64	neutral	-1.92	low_impact	1.54	0.71	neutral	0.75	neutral	2.42	18.96	deleterious	0.08	0.35	0.29	neutral	0.69	disease	0.43	neutral	0.51	disease	0	0.11	neutral	0.88	deleterious	-6	neutral	0.18	neutral	0.37	medium_impact	0.55	medium_impact	0.2	medium_impact	0.15	0.8	26.05	51.21	0.32	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9685	9685	T	A	MI.7649	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	479	160	I	N	aTt/aAt	0.13	0	0	benign	0	neutral	0.42	neutral	2.15	neutral	-2.61	deleterious	-2.73	low_impact	1.47	0.72	neutral	0.72	neutral	1.54	13.54	neutral	0.21	0.45	0.38	neutral	0.71	disease	0.32	neutral	0.51	disease	0	0.58	neutral	0.71	deleterious	-6	neutral	0.19	neutral	2.05	high_impact	0.11	medium_impact	0.14	medium_impact	0.16	0.8	26.05	51.21	0.38	N	0.20	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8887	8887	A	T	MI.765	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	361	121	I	F	Att/Ttt	0.36	0.13	0.01	benign	0	neutral	0.54	neutral	4.43	neutral	-0.55	neutral	-1.08	neutral_impact	-0.9	0.9	neutral	0.64	neutral	1.53	13.50	neutral	0.47	0.65	0.62	disease	0.58	disease	0.36	neutral	0.42	neutral	2	0.46	neutral	0.77	deleterious	-6	neutral	0.23	neutral	2.09	high_impact	0.33	medium_impact	-1.87	low_impact	0.64	0.9	23.01	21.88	0.28	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9685	9685	T	C	MI.7650	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	479	160	I	T	aTt/aCt	0.13	0	0	benign	0	neutral	0.9	neutral	2.22	neutral	-1.06	neutral	-0.96	low_impact	1	0.7	neutral	0.75	neutral	-0.07	1.95	neutral	0.23	0.45	0.22	neutral	0.41	neutral	0.33	neutral	0.44	neutral	1	0.09	neutral	0.95	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.74	medium_impact	-0.29	medium_impact	0.26	0.8	26.05	51.21	0.35	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9686	9686	T	G	MI.7651	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	480	160	I	M	atT/atG	1.05	0	0	possibly_damaging	0.47	neutral	0.24	neutral	2.17	neutral	-1.87	neutral	-0.94	low_impact	1.73	0.78	neutral	0.75	neutral	2.22	17.65	deleterious	0.47	0.55	0.26	neutral	0.46	neutral	0.3	neutral	0.47	neutral	1	0.73	neutral	0.39	neutral	-3	neutral	0.36	neutral	-0.82	medium_impact	-0.09	medium_impact	0.37	medium_impact	0.64	0.8	26.05	51.21	0.42	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9686	9686	T	A	MI.7652	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	480	160	I	M	atT/atA	1.05	0	0	possibly_damaging	0.47	neutral	0.24	neutral	2.17	neutral	-1.87	neutral	-0.94	low_impact	1.73	0.78	neutral	0.75	neutral	2.45	19.18	deleterious	0.47	0.55	0.26	neutral	0.46	neutral	0.3	neutral	0.47	neutral	1	0.73	neutral	0.39	neutral	-3	neutral	0.36	neutral	-0.82	medium_impact	-0.09	medium_impact	0.37	medium_impact	0.64	0.8	26.05	51.21	0.43	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9687	9687	C	A	MI.7653	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	481	161	Q	K	Caa/Aaa	-6.58	0	0	possibly_damaging	0.86	neutral	0.32	neutral	2.58	neutral	-0.17	neutral	-2.33	low_impact	1.55	0.5	damaging	0.06	damaging	3.91	23.50	deleterious	0.25	0.45	0.11	neutral	0.84	disease	0.32	neutral	0.5	neutral	0	0.88	neutral	0.23	neutral	-3	neutral	0.60	deleterious	-1.64	low_impact	0.01	medium_impact	0.21	medium_impact	0.38	0.8	75.1	11.31	0.28	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9687	9687	C	G	MI.7654	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	481	161	Q	E	Caa/Gaa	-6.58	0	0	possibly_damaging	0.72	neutral	0.29	neutral	2.55	neutral	-0.76	neutral	-2.01	medium_impact	2	0.51	damaging	0.04	damaging	3.16	22.60	deleterious	0.42	0.55	0.15	neutral	0.81	disease	0.4	neutral	0.63	disease	3	0.79	neutral	0.29	neutral	0	NA	0.60	deleterious	-1.27	low_impact	-0.03	medium_impact	0.61	medium_impact	0.50	0.8	75.1	11.31	0.26	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9688	9688	A	T	MI.7655	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	482	161	Q	L	cAa/cTa	7.3	1	0	possibly_damaging	0.86	neutral	0.75	neutral	2.72	neutral	1.49	deleterious	-4.08	neutral_impact	0.6	0.5	damaging	0.06	damaging	3.80	23.40	deleterious	0.12	0.4	0.15	neutral	0.82	disease	0.28	neutral	0.47	neutral	1	0.83	neutral	0.45	neutral	-3	neutral	0.65	deleterious	-1.64	low_impact	0.46	medium_impact	-0.65	medium_impact	0.12	0.8	75.1	11.31	0.42	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9688	9688	A	G	MI.7656	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	482	161	Q	R	cAa/cGa	7.3	1	0	possibly_damaging	0.9	neutral	0.35	neutral	2.6	neutral	0.27	neutral	-2.5	low_impact	1.6	0.5	damaging	0.06	damaging	3.47	23.00	deleterious	0.25	0.45	0.2	neutral	0.84	disease	0.36	neutral	0.52	disease	0	0.91	neutral	0.23	neutral	-3	neutral	0.69	deleterious	-1.8	low_impact	0.04	medium_impact	0.25	medium_impact	0.11	0.8	75.1	11.31	0.47	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9688	9688	A	C	MI.7657	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	482	161	Q	P	cAa/cCa	7.3	1	0	probably_damaging	0.96	neutral	0.2	neutral	2.54	neutral	-1.34	deleterious	-4.13	high_impact	3.5	0.46	damaging	0.02	damaging	3.38	22.90	deleterious	0.06	0.35	0.37	neutral	0.94	disease	0.55	disease	0.76	disease	5	0.97	neutral	0.12	neutral	2	deleterious	0.80	deleterious	-2.21	low_impact	-0.15	medium_impact	1.95	medium_impact	0.32	0.8	75.1	11.31	0.49	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9689	9689	A	C	MI.7658	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	483	161	Q	H	caA/caC	8.69	1	0	probably_damaging	0.97	neutral	0.56	neutral	2.54	neutral	-1.17	deleterious	-3.03	medium_impact	2	0.57	damaging	0.3	neutral	2.28	18.01	deleterious	0.32	0.5	0.3	neutral	0.72	disease	0.3	neutral	0.49	neutral	0	0.97	neutral	0.3	neutral	1	deleterious	0.74	deleterious	-2.34	low_impact	0.25	medium_impact	0.61	medium_impact	0.43	0.8	75.1	11.31	0.44	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9689	9689	A	T	MI.7659	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	483	161	Q	H	caA/caT	8.69	1	0	probably_damaging	0.97	neutral	0.56	neutral	2.54	neutral	-1.17	deleterious	-3.03	medium_impact	2	0.57	damaging	0.3	neutral	2.41	18.91	deleterious	0.32	0.5	0.3	neutral	0.72	disease	0.3	neutral	0.49	neutral	0	0.97	neutral	0.3	neutral	1	deleterious	0.74	deleterious	-2.34	low_impact	0.25	medium_impact	0.61	medium_impact	0.43	0.8	75.1	11.31	0.44	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8887	8887	A	G	MI.766	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	361	121	I	V	Att/Gtt	0.36	0.13	0.01	benign	0	neutral	0.24	neutral	4.41	neutral	0.63	neutral	0.64	neutral_impact	0.14	0.93	neutral	0.62	neutral	0.94	10.33	neutral	0.67	0.75	0.43	neutral	0.31	neutral	0.5	neutral	0.46	neutral	1	0.76	neutral	0.62	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	0.01	medium_impact	-0.98	medium_impact	0.63	0.9	23.01	21.88	0.36	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9690	9690	G	C	MI.7660	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	484	162	A	P	Gca/Cca	0.13	0.96	0	probably_damaging	1	neutral	0.24	neutral	2.5	neutral	-2.93	deleterious	-3.33	medium_impact	2.64	0.46	damaging	0.03	damaging	3.89	23.50	deleterious	0.04	0.35	0.46	neutral	0.92	disease	0.7	disease	0.79	disease	6	1	deleterious	0.12	neutral	1	deleterious	0.85	deleterious	-3.78	low_impact	-0.09	medium_impact	1.18	medium_impact	0.52	0.8	72.03	11.53	0.36	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9690	9690	G	T	MI.7661	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	484	162	A	S	Gca/Tca	0.13	0.96	0	probably_damaging	0.99	neutral	0.61	neutral	2.57	neutral	-0.68	neutral	-0.62	neutral_impact	-0.07	0.61	neutral	0.36	neutral	1.54	13.55	neutral	0.3	0.45	0.17	neutral	0.26	neutral	0.25	neutral	0.44	neutral	1	0.99	deleterious	0.31	neutral	-2	neutral	0.68	deleterious	-2.81	low_impact	0.3	medium_impact	-1.25	low_impact	0.41	0.8	72.03	11.53	0.35	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9690	9690	G	A	MI.7662	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	484	162	A	T	Gca/Aca	0.13	0.96	0	probably_damaging	0.99	neutral	0.53	neutral	2.52	neutral	-0.95	neutral	-2.34	medium_impact	2.09	0.48	damaging	0.03	damaging	4.30	24.00	deleterious	0.21	0.45	0.25	neutral	0.66	disease	0.57	disease	0.63	disease	3	0.99	deleterious	0.27	neutral	1	deleterious	0.72	deleterious	-2.81	low_impact	0.22	medium_impact	0.69	medium_impact	0.72	0.85	72.03	11.53	0.35	N	0.86	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9691	9691	C	G	MI.7663	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	485	162	A	G	gCa/gGa	2.9	1	0	probably_damaging	0.98	neutral	0.49	neutral	2.59	neutral	0.34	neutral	-0.75	neutral_impact	-0.22	0.56	damaging	0.17	damaging	2.32	18.33	deleterious	0.25	0.45	0.23	neutral	0.16	neutral	0.26	neutral	0.24	neutral	5	0.97	neutral	0.26	neutral	-2	neutral	0.66	deleterious	-2.51	low_impact	0.18	medium_impact	-1.38	low_impact	0.44	0.8	72.03	11.53	0.45	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9691	9691	C	A	MI.7664	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	485	162	A	E	gCa/gAa	2.9	1	0	probably_damaging	1	neutral	0.42	neutral	2.5	neutral	-2.1	deleterious	-3.07	medium_impact	3.34	0.5	damaging	0.03	damaging	4.51	24.30	deleterious	0.03	0.35	0.27	neutral	0.89	disease	0.7	disease	0.78	disease	6	1	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	0.11	medium_impact	1.81	medium_impact	0.31	0.8	72.03	11.53	0.4	N	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9691	9691	C	T	MI.7665	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	485	162	A	V	gCa/gTa	2.9	1	0	probably_damaging	0.99	neutral	0.61	neutral	2.55	neutral	-0.37	deleterious	-3.36	medium_impact	2.79	0.46	damaging	0.04	damaging	4.42	24.20	deleterious	0.21	0.45	0.21	neutral	0.71	disease	0.58	disease	0.69	disease	4	0.99	deleterious	0.31	neutral	1	deleterious	0.73	deleterious	-2.81	low_impact	0.3	medium_impact	1.32	medium_impact	0.68	0.85	72.03	11.53	0.45	N	0.87	polymorphism	1	0.12	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9693	9693	C	A	MI.7666	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	487	163	L	M	Ctg/Atg	-9.59	0	0	probably_damaging	1	neutral	0.2	neutral	1.97	neutral	-2.43	neutral	-1.89	medium_impact	2.54	0.49	damaging	0.08	damaging	3.83	23.40	deleterious	0.17	0.45	0.32	neutral	0.58	disease	0.44	neutral	0.43	neutral	1	1	deleterious	0.1	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.15	medium_impact	1.09	medium_impact	0.47	0.8	75.48	11.49	0.31	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9693	9693	C	G	MI.7667	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	487	163	L	V	Ctg/Gtg	-9.59	0	0	probably_damaging	0.95	neutral	0.31	neutral	1.98	neutral	-2.51	deleterious	-2.75	high_impact	3.8	0.52	damaging	0.01	damaging	3.47	23.00	deleterious	0.15	0.4	0.22	neutral	0.72	disease	0.65	disease	0.66	disease	3	0.96	neutral	0.18	neutral	2	deleterious	0.72	deleterious	-2.11	low_impact	-0.01	medium_impact	2.22	high_impact	0.61	0.8	75.48	11.49	0.28	N	0.81	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9694	9694	T	G	MI.7668	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	488	163	L	R	cTg/cGg	-0.33	0	0	probably_damaging	1	neutral	0.11	neutral	1.93	deleterious	-4.88	deleterious	-5.75	high_impact	4.6	0.68	neutral	0.02	damaging	4.19	23.80	deleterious	0.02	0.35	0.56	disease	0.93	disease	0.76	disease	0.81	disease	6	1	deleterious	0.06	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.33	medium_impact	2.94	high_impact	0.18	0.8	75.48	11.49	0.46	N	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9694	9694	T	C	MI.7669	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	488	163	L	P	cTg/cCg	-0.33	0	0	probably_damaging	1	neutral	0.07	neutral	1.91	deleterious	-5.27	deleterious	-6.68	high_impact	4.05	0.59	damaging	0.03	damaging	3.96	23.60	deleterious	0.02	0.35	0.65	disease	0.9	disease	0.75	disease	0.81	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.45	medium_impact	2.45	high_impact	0.37	0.8	75.48	11.49	0.33	N	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8887	8887	A	C	MI.767	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	361	121	I	L	Att/Ctt	0.36	0.13	0.01	benign	0	neutral	0.34	neutral	4.41	neutral	0.27	neutral	0.1	neutral_impact	-0.46	0.93	neutral	0.88	neutral	0.44	6.92	deleterious	0.57	0.65	0.28	neutral	0.37	neutral	0.46	neutral	0.45	neutral	1	0.66	neutral	0.67	deleterious	-6	neutral	0.14	neutral	2.09	high_impact	0.13	medium_impact	-1.49	low_impact	0.63	0.9	23.01	21.88	0.41	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9694	9694	T	A	MI.7670	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	488	163	L	Q	cTg/cAg	-0.33	0	0	probably_damaging	1	neutral	0.25	neutral	1.92	deleterious	-4.55	deleterious	-5.75	high_impact	4.25	0.62	neutral	0.02	damaging	4.25	23.90	deleterious	0.03	0.35	0.58	disease	0.87	disease	0.66	disease	0.73	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.08	medium_impact	2.63	high_impact	0.28	0.8	75.48	11.49	0.34	N	0.97	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9696	9696	C	G	MI.7671	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	490	164	L	V	Ctt/Gtt	-4.5	0	0	benign	0.06	neutral	0.33	neutral	2.29	neutral	-0.23	neutral	-0.44	neutral_impact	0.79	0.76	neutral	0.85	neutral	-0.29	0.71	neutral	0.36	0.5	0.12	neutral	0.27	neutral	0.21	neutral	0.41	neutral	2	0.64	neutral	0.64	deleterious	-6	neutral	0.14	neutral	0.29	medium_impact	0.02	medium_impact	-0.48	medium_impact	0.61	0.8	22.99	31.12	0.42	N	0.35	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9696	9696	C	T	MI.7672	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	490	164	L	F	Ctt/Ttt	-4.5	0	0	benign	0	neutral	0.47	neutral	2.22	neutral	-0.79	neutral	-0.21	neutral_impact	0.6	0.78	neutral	0.98	neutral	-0.37	0.46	neutral	0.27	0.45	0.21	neutral	0.2	neutral	0.21	neutral	0.37	neutral	3	0.53	neutral	0.74	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	0.16	medium_impact	-0.65	medium_impact	0.53	0.8	22.99	31.12	0.43	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9696	9696	C	A	MI.7673	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	490	164	L	I	Ctt/Att	-4.5	0	0	benign	0.06	neutral	0.38	neutral	2.28	neutral	-0.28	neutral	-0.24	neutral_impact	0.34	0.8	neutral	0.86	neutral	0.54	7.72	deleterious	0.34	0.5	0.14	neutral	0.18	neutral	0.17	neutral	0.31	neutral	4	0.58	neutral	0.66	deleterious	-6	neutral	0.14	neutral	0.29	medium_impact	0.07	medium_impact	-0.88	medium_impact	0.52	0.8	22.99	31.12	0.47	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9697	9697	T	A	MI.7674	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	491	164	L	H	cTt/cAt	-3.11	0	0	possibly_damaging	0.62	neutral	0.35	neutral	2.09	deleterious	-3.69	deleterious	-2.51	medium_impact	3.36	0.75	neutral	0.51	neutral	2.02	16.33	deleterious	0.05	0.35	0.51	disease	0.61	disease	0.44	neutral	0.46	neutral	1	0.69	neutral	0.37	neutral	0	NA	0.58	deleterious	-1.08	low_impact	0.04	medium_impact	1.83	medium_impact	0.21	0.8	22.99	31.12	0.37	N	0.70	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9697	9697	T	G	MI.7675	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	491	164	L	R	cTt/cGt	-3.11	0	0	benign	0.3	neutral	0.18	neutral	2.1	deleterious	-3.05	neutral	-2.38	medium_impact	3.02	0.64	neutral	0.48	neutral	2.19	17.43	deleterious	0.02	0.35	0.42	neutral	0.8	disease	0.5	neutral	0.65	disease	3	0.79	neutral	0.44	neutral	-3	neutral	0.45	deleterious	-0.51	medium_impact	-0.18	medium_impact	1.52	medium_impact	0.26	0.8	22.99	31.12	0.39	N	0.82	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9697	9697	T	C	MI.7676	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	491	164	L	P	cTt/cCt	-3.11	0	0	possibly_damaging	0.45	neutral	0.11	neutral	2.09	deleterious	-3.73	deleterious	-2.82	medium_impact	3.02	0.56	damaging	0.35	neutral	2.27	17.98	deleterious	0.02	0.35	0.52	disease	0.84	disease	0.53	disease	0.74	disease	5	0.88	neutral	0.33	neutral	0	NA	0.57	deleterious	-0.78	medium_impact	-0.33	medium_impact	1.52	medium_impact	0.22	0.8	22.99	31.12	0.35	N	0.90	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9699	9699	A	G	MI.7677	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	493	165	I	V	Att/Gtt	-14.22	0	0	benign	0.01	neutral	0.29	neutral	2.33	neutral	0.08	neutral	-0.67	neutral_impact	0.42	0.78	neutral	0.75	neutral	1.18	11.66	neutral	0.4	0.5	0.13	neutral	0.31	neutral	0.31	neutral	0.44	neutral	1	0.7	neutral	0.64	deleterious	-6	neutral	0.09	neutral	1.07	medium_impact	-0.03	medium_impact	-0.81	medium_impact	0.31	0.8	20.69	32.67	0.36	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9699	9699	A	C	MI.7678	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	493	165	I	L	Att/Ctt	-14.22	0	0	benign	0.04	neutral	1	neutral	2.51	neutral	1	neutral	0.36	neutral_impact	-0.57	0.73	neutral	0.83	neutral	-0.72	0.06	neutral	0.26	0.45	0.13	neutral	0.22	neutral	0.22	neutral	0.41	neutral	2	0.04	neutral	0.98	deleterious	-6	neutral	0.10	neutral	0.47	medium_impact	1.9	high_impact	-1.69	low_impact	0.39	0.8	20.69	32.67	0.32	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9699	9699	A	T	MI.7679	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	493	165	I	F	Att/Ttt	-14.22	0	0	benign	0.41	neutral	0.6	neutral	2.2	neutral	-1.24	neutral	-1.35	neutral_impact	0.7	0.71	neutral	0.75	neutral	2.29	18.09	deleterious	0.19	0.45	0.2	neutral	0.54	disease	0.31	neutral	0.45	neutral	1	0.37	neutral	0.6	deleterious	-6	neutral	0.40	neutral	-0.72	medium_impact	0.29	medium_impact	-0.56	medium_impact	0.46	0.8	20.69	32.67	0.32	N	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8888	8888	T	A	MI.768	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	362	121	I	N	aTt/aAt	1.05	0.13	0	benign	0	neutral	0.14	neutral	4.42	neutral	-1.69	neutral	-0.14	neutral_impact	0.06	0.88	neutral	0.52	neutral	2.49	19.38	deleterious	0.58	0.7	0.55	disease	0.76	disease	0.64	disease	0.67	disease	3	0.86	neutral	0.57	deleterious	-6	neutral	0.25	neutral	2.09	high_impact	-0.15	medium_impact	-1.05	low_impact	0.45	0.9	23.01	21.88	0.35	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9700	9700	T	C	MI.7680	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	494	165	I	T	aTt/aCt	0.36	0.01	0	benign	0.01	neutral	0.48	neutral	2.17	neutral	-1.8	deleterious	-2.89	medium_impact	1.97	0.7	neutral	0.69	neutral	0.31	5.81	deleterious	0.13	0.4	0.19	neutral	0.54	disease	0.51	disease	0.49	neutral	0	0.51	neutral	0.74	deleterious	-3	neutral	0.12	neutral	1.07	medium_impact	0.17	medium_impact	0.58	medium_impact	0.26	0.8	20.69	32.67	0.42	N	0.91	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9700	9700	T	A	MI.7681	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	494	165	I	N	aTt/aAt	0.36	0.01	0	benign	0.37	neutral	0.13	neutral	2.13	deleterious	-3.25	deleterious	-4.57	medium_impact	2.87	0.67	neutral	0.29	neutral	4.04	23.70	deleterious	0.1	0.4	0.5	disease	0.81	disease	0.53	disease	0.74	disease	5	0.85	neutral	0.38	neutral	-3	neutral	0.56	deleterious	-0.64	medium_impact	-0.28	medium_impact	1.39	medium_impact	0.34	0.8	20.69	32.67	0.34	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9700	9700	T	G	MI.7682	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	494	165	I	S	aTt/aGt	0.36	0.01	0	benign	0.17	neutral	0.12	neutral	2.16	neutral	-2.21	deleterious	-3.52	medium_impact	2.32	0.66	neutral	0.39	neutral	2.67	20.60	deleterious	0.04	0.35	0.32	neutral	0.73	disease	0.43	neutral	0.52	disease	0	0.86	neutral	0.48	deleterious	-3	neutral	0.30	neutral	-0.2	medium_impact	-0.3	medium_impact	0.9	medium_impact	0.25	0.8	20.69	32.67	0.44	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9701	9701	T	G	MI.7683	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	495	165	I	M	atT/atG	3.83	0.4	0.01	possibly_damaging	0.61	neutral	0.11	neutral	2.2	neutral	-1.34	neutral	-0.13	neutral_impact	0.77	0.72	neutral	0.73	neutral	1.99	16.16	deleterious	0.29	0.45	0.28	neutral	0.43	neutral	0.3	neutral	0.46	neutral	1	0.89	neutral	0.25	neutral	-3	neutral	0.44	deleterious	-1.06	low_impact	-0.33	medium_impact	-0.49	medium_impact	0.50	0.8	20.69	32.67	0.46	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9701	9701	T	A	MI.7684	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	495	165	I	M	atT/atA	3.83	0.4	0.01	possibly_damaging	0.61	neutral	0.11	neutral	2.2	neutral	-1.34	neutral	-0.13	neutral_impact	0.77	0.72	neutral	0.73	neutral	2.28	18.06	deleterious	0.29	0.45	0.28	neutral	0.43	neutral	0.3	neutral	0.46	neutral	1	0.89	neutral	0.25	neutral	-3	neutral	0.44	deleterious	-1.06	low_impact	-0.33	medium_impact	-0.49	medium_impact	0.50	0.8	20.69	32.67	0.46	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9702	9702	A	G	MI.7685	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	496	166	T	A	Aca/Gca	-6.35	0	0	probably_damaging	0.95	neutral	0.52	neutral	1.98	deleterious	-3.1	deleterious	-4.82	medium_impact	3.44	0.66	neutral	0.03	damaging	3.51	23.10	deleterious	0.1	0.4	0.45	neutral	0.65	disease	0.68	disease	0.49	neutral	0	0.95	neutral	0.29	neutral	1	deleterious	0.72	deleterious	-2.11	low_impact	0.21	medium_impact	1.9	medium_impact	0.28	0.8	74.33	11.51	0.25	N	0.44	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9702	9702	A	T	MI.7686	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	496	166	T	S	Aca/Tca	-6.35	0	0	probably_damaging	0.95	neutral	0.41	neutral	1.95	deleterious	-3.56	deleterious	-3.86	medium_impact	2.65	0.66	neutral	0.03	damaging	3.30	22.90	deleterious	0.14	0.4	0.52	disease	0.72	disease	0.67	disease	0.6	disease	2	0.95	neutral	0.23	neutral	1	deleterious	0.74	deleterious	-2.11	low_impact	0.1	medium_impact	1.19	medium_impact	0.53	0.8	74.33	11.51	0.21	N	0.77	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9702	9702	A	C	MI.7687	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	496	166	T	P	Aca/Cca	-6.35	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.84	deleterious	-6.01	deleterious	-5.78	high_impact	4.73	0.68	neutral	0.05	damaging	3.51	23.10	deleterious	0.03	0.35	0.76	disease	0.88	disease	0.8	disease	0.8	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-2.81	low_impact	-0.15	medium_impact	3.06	high_impact	0.34	0.8	74.33	11.51	0.61	P	0.98	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9703	9703	C	T	MI.7688	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	497	166	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	neutral	0.24	neutral	1.84	deleterious	-5.39	deleterious	-5.78	high_impact	4.73	0.69	neutral	0.01	damaging	4.02	23.60	deleterious	0.04	0.35	0.7	disease	0.87	disease	0.72	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.09	medium_impact	3.06	high_impact	0.45	0.8	74.33	11.51	0.69	P	0.96	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9703	9703	C	A	MI.7689	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	497	166	T	K	aCa/aAa	8.69	1	0	probably_damaging	0.99	neutral	0.28	neutral	1.84	deleterious	-4.75	deleterious	-5.78	high_impact	4.73	0.72	neutral	0.02	damaging	4.43	24.20	deleterious	0.05	0.35	0.65	disease	0.92	disease	0.79	disease	0.81	disease	6	0.99	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.04	medium_impact	3.06	high_impact	0.33	0.8	74.33	11.51	0.73	P	0.99	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8888	8888	T	C	MI.769	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	362	121	I	T	aTt/aCt	1.05	0.13	0	benign	0	neutral	0.71	neutral	4.47	neutral	-1.01	neutral	2.42	neutral_impact	-1.76	0.92	neutral	0.97	neutral	-0.48	0.24	neutral	0.58	0.7	0.29	neutral	0.16	neutral	0.37	neutral	0.29	neutral	4	0.29	neutral	0.86	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	0.51	medium_impact	-2.61	low_impact	0.37	0.9	23.01	21.88	0.29	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9705	9705	A	G	MI.7690	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	499	167	I	V	Att/Gtt	-20	0	0	possibly_damaging	0.87	neutral	0.43	neutral	2.24	neutral	-0.36	neutral	0.14	neutral_impact	0.07	0.69	neutral	0.78	neutral	-0.54	0.18	neutral	0.41	0.5	0.14	neutral	0.09	neutral	0.28	neutral	0.25	neutral	5	0.86	neutral	0.28	neutral	-3	neutral	0.44	deleterious	-1.67	low_impact	0.12	medium_impact	-1.12	low_impact	0.42	0.8	74.33	11.42	0.41	N	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9705	9705	A	C	MI.7691	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	499	167	I	L	Att/Ctt	-20	0	0	probably_damaging	0.95	neutral	1	neutral	2.09	neutral	-1.23	neutral	-1.75	low_impact	1.77	0.62	neutral	0.69	neutral	3.51	23.10	deleterious	0.24	0.45	0.15	neutral	0.7	disease	0.32	neutral	0.5	neutral	0	0.95	neutral	0.53	deleterious	-2	neutral	0.50	deleterious	-2.11	low_impact	1.9	high_impact	0.4	medium_impact	0.48	0.8	74.33	11.42	0.28	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9705	9705	A	T	MI.7692	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	499	167	I	F	Att/Ttt	-20	0	0	probably_damaging	0.99	neutral	0.78	neutral	1.95	neutral	-2.95	deleterious	-3.6	medium_impact	2.33	0.61	neutral	0.45	neutral	4.03	23.70	deleterious	0.17	0.45	0.25	neutral	0.81	disease	0.6	disease	0.66	disease	3	0.99	deleterious	0.4	neutral	1	deleterious	0.71	deleterious	-2.81	low_impact	0.51	medium_impact	0.91	medium_impact	0.50	0.8	74.33	11.42	0.27	N	0.94	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9706	9706	T	G	MI.7693	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	500	167	I	S	aTt/aGt	2.21	0.95	0	probably_damaging	1	neutral	0.34	neutral	1.93	deleterious	-3.58	deleterious	-4.66	medium_impact	3.42	0.64	neutral	0.44	neutral	4.27	23.90	deleterious	0.04	0.35	0.47	neutral	0.82	disease	0.57	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.03	medium_impact	1.88	medium_impact	0.29	0.8	74.33	11.42	0.44	N	0.93	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9706	9706	T	A	MI.7694	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	500	167	I	N	aTt/aAt	2.21	0.95	0	probably_damaging	1	neutral	0.19	neutral	1.9	deleterious	-4.67	deleterious	-5.71	high_impact	3.98	0.6	damaging	0.38	neutral	4.65	24.50	deleterious	0.09	0.35	0.65	disease	0.87	disease	0.59	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.17	medium_impact	2.38	high_impact	0.30	0.8	74.33	11.42	0.49	N	0.97	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9706	9706	T	C	MI.7695	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	500	167	I	T	aTt/aCt	2.21	0.95	0	probably_damaging	1	neutral	0.85	neutral	1.94	deleterious	-3.03	deleterious	-3.21	medium_impact	2.69	0.67	neutral	0.55	neutral	1.69	14.34	neutral	0.1	0.4	0.33	neutral	0.63	disease	0.56	disease	0.49	neutral	0	1	deleterious	0.43	neutral	1	deleterious	0.69	deleterious	-3.78	low_impact	0.62	medium_impact	1.23	medium_impact	0.35	0.8	74.33	11.42	0.36	N	0.91	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9707	9707	T	A	MI.7696	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	501	167	I	M	atT/atA	7.53	0.99	0	probably_damaging	1	neutral	0.18	neutral	1.94	deleterious	-3.19	neutral	-2.17	medium_impact	2.27	0.61	neutral	0.48	neutral	3.84	23.40	deleterious	0.28	0.45	0.43	neutral	0.7	disease	0.59	disease	0.68	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.71	deleterious	-3.78	low_impact	-0.18	medium_impact	0.85	medium_impact	0.58	0.8	74.33	11.42	0.52	P	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9707	9707	T	G	MI.7697	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	501	167	I	M	atT/atG	7.53	0.99	0	probably_damaging	1	neutral	0.18	neutral	1.94	deleterious	-3.19	neutral	-2.17	medium_impact	2.27	0.61	neutral	0.48	neutral	3.47	23.00	deleterious	0.28	0.45	0.43	neutral	0.7	disease	0.59	disease	0.68	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.71	deleterious	-3.78	low_impact	-0.18	medium_impact	0.85	medium_impact	0.58	0.8	74.33	11.42	0.52	P	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9708	9708	T	G	MI.7698	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	502	168	L	V	Tta/Gta	-8.2	0	0	probably_damaging	0.98	neutral	0.56	neutral	2.41	neutral	-0.94	neutral	-0.31	neutral_impact	0.6	0.79	neutral	0.85	neutral	1.93	15.76	deleterious	0.29	0.45	0.19	neutral	0.27	neutral	0.23	neutral	0.44	neutral	1	0.98	deleterious	0.29	neutral	-2	neutral	0.63	deleterious	-2.51	low_impact	0.25	medium_impact	-0.65	medium_impact	0.42	0.8	9.96	29.93	0.28	N	0.31	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9708	9708	T	A	MI.7699	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	502	168	L	M	Tta/Ata	-8.2	0	0	probably_damaging	1	neutral	0.12	neutral	2.29	deleterious	-3	neutral	-0.54	low_impact	1.39	0.81	neutral	0.94	neutral	2.34	18.45	deleterious	0.25	0.45	0.38	neutral	0.27	neutral	0.24	neutral	0.46	neutral	1	1	deleterious	0.06	neutral	-2	neutral	0.65	deleterious	-3.78	low_impact	-0.3	medium_impact	0.06	medium_impact	0.35	0.8	9.96	29.93	0.45	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8560	8560	C	T	MI.77	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	34	12	P	S	Ccc/Tcc	0.36	0.11	0	probably_damaging	1	neutral	0.73	neutral	4.74	neutral	0.74	deleterious	-6.74	medium_impact	2.21	0.61	neutral	0.08	damaging	3.66	23.20	deleterious	0.54	0.65	0.29	neutral	0.75	disease	0.52	disease	0.52	disease	0	1	deleterious	0.37	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.54	medium_impact	0.8	medium_impact	0.26	0.9	50	8.94	0.21	N	0.79	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8888	8888	T	G	MI.770	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	362	121	I	S	aTt/aGt	1.05	0.13	0	benign	0	neutral	0.28	neutral	4.44	neutral	-1.41	neutral	0.9	neutral_impact	-0.34	0.83	neutral	0.53	neutral	2.35	18.49	deleterious	0.49	0.65	0.45	neutral	0.63	disease	0.46	neutral	0.42	neutral	2	0.72	neutral	0.64	deleterious	-6	neutral	0.20	neutral	2.09	high_impact	0.06	medium_impact	-1.39	low_impact	0.40	0.9	23.01	21.88	0.33	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9709	9709	T	C	MI.7700	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	503	168	L	S	tTa/tCa	-5.89	0	0	probably_damaging	0.99	neutral	0.19	neutral	2.3	deleterious	-3.17	deleterious	-3.12	low_impact	1.41	0.8	neutral	0.93	neutral	0.75	9.15	deleterious	0.07	0.35	0.26	neutral	0.46	neutral	0.4	neutral	0.46	neutral	1	1	deleterious	0.1	neutral	-2	neutral	0.65	deleterious	-2.81	low_impact	-0.17	medium_impact	0.08	medium_impact	0.28	0.8	9.96	29.93	0.37	N	0.12	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9709	9709	T	G	MI.7701	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	503	168	L	W	tTa/tGa	-5.89	0	0	probably_damaging	1	neutral	0.08	neutral	2.26	deleterious	-4.99	deleterious	-4.05	medium_impact	2.73	0.65	neutral	0.36	neutral	3.68	23.30	deleterious	0.07	0.35	0.53	disease	0.72	disease	0.51	disease	0.55	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.41	medium_impact	1.26	medium_impact	0.21	0.8	9.96	29.93	0.3	N	0.59	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9710	9710	A	C	MI.7702	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	504	168	L	F	ttA/ttC	-0.57	0	0	probably_damaging	0.99	neutral	0.44	neutral	2.33	neutral	-2.61	neutral	-2.15	low_impact	0.98	0.8	neutral	0.83	neutral	2.34	18.43	deleterious	0.25	0.45	0.39	neutral	0.43	neutral	0.26	neutral	0.47	neutral	1	0.99	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-2.81	low_impact	0.13	medium_impact	-0.3	medium_impact	0.42	0.8	9.96	29.93	0.32	N	0.36	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9710	9710	A	T	MI.7703	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	504	168	L	F	ttA/ttT	-0.57	0	0	probably_damaging	0.99	neutral	0.44	neutral	2.33	neutral	-2.61	neutral	-2.15	low_impact	0.98	0.8	neutral	0.83	neutral	2.45	19.14	deleterious	0.25	0.45	0.39	neutral	0.43	neutral	0.26	neutral	0.47	neutral	1	0.99	deleterious	0.23	neutral	-2	neutral	0.68	deleterious	-2.81	low_impact	0.13	medium_impact	-0.3	medium_impact	0.42	0.8	9.96	29.93	0.32	N	0.36	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9711	9711	C	A	MI.7704	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	505	169	L	M	Ctg/Atg	-6.12	0	0.01	probably_damaging	1	neutral	0.21	neutral	1.68	deleterious	-3.88	neutral	-1.6	medium_impact	2.45	0.53	damaging	0.04	damaging	3.80	23.40	deleterious	0.2	0.45	0.35	neutral	0.67	disease	0.55	disease	0.56	disease	1	1	deleterious	0.11	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	-0.14	medium_impact	1.01	medium_impact	0.46	0.8	73.18	11.49	0.26	N	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9711	9711	C	G	MI.7705	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	505	169	L	V	Ctg/Gtg	-6.12	0	0.01	probably_damaging	0.98	neutral	0.61	neutral	1.78	neutral	-2.41	deleterious	-2.72	high_impact	4.7	0.52	damaging	0.03	damaging	3.49	23.10	deleterious	0.18	0.45	0.3	neutral	0.66	disease	0.65	disease	0.67	disease	3	0.97	neutral	0.32	neutral	2	deleterious	0.73	deleterious	-2.51	low_impact	0.3	medium_impact	3.03	high_impact	0.39	0.8	73.18	11.49	0.45	N	0.81	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9712	9712	T	G	MI.7706	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	506	169	L	R	cTg/cGg	-1.03	0	0	probably_damaging	1	neutral	0.24	neutral	1.65	deleterious	-4.99	deleterious	-5.58	high_impact	4.7	0.66	neutral	0.02	damaging	4.21	23.90	deleterious	0.04	0.35	0.63	disease	0.92	disease	0.76	disease	0.8	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.09	medium_impact	3.03	high_impact	0.15	0.8	73.18	11.49	0.56	P	0.99	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9712	9712	T	C	MI.7707	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	506	169	L	P	cTg/cCg	-1.03	0	0	probably_damaging	1	neutral	0.14	neutral	1.64	deleterious	-5.69	deleterious	-6.53	high_impact	4.34	0.57	damaging	0.03	damaging	3.99	23.60	deleterious	0.04	0.35	0.72	disease	0.86	disease	0.76	disease	0.78	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.26	medium_impact	2.71	high_impact	0.25	0.8	73.18	11.49	0.37	N	0.99	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9712	9712	T	A	MI.7708	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	506	169	L	Q	cTg/cAg	-1.03	0	0	probably_damaging	1	neutral	0.25	neutral	1.65	deleterious	-5.14	deleterious	-5.51	high_impact	4.7	0.62	neutral	0.02	damaging	4.23	23.90	deleterious	0.05	0.35	0.65	disease	0.83	disease	0.65	disease	0.7	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.08	medium_impact	3.03	high_impact	0.25	0.8	73.18	11.49	0.51	N	0.97	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9714	9714	G	A	MI.7709	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	508	170	G	S	Ggt/Agt	-0.33	0.22	0	probably_damaging	1	neutral	0.37	neutral	1.31	deleterious	-4.63	deleterious	-5.79	medium_impact	3.42	0.56	damaging	0.01	damaging	4.20	23.90	deleterious	0.06	0.35	0.32	neutral	0.8	disease	0.62	disease	0.62	disease	2	1	deleterious	0.19	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.06	medium_impact	1.88	medium_impact	0.55	0.8	73.95	11.77	0.27	N	0.85	polymorphism	1	0.26	.	Uncertain_significance	not_specified	433704	MedGen:CN169374	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8889	8889	T	A	MI.771	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	363	121	I	M	atT/atA	1.75	0.12	0	benign	0	neutral	0.09	neutral	4.38	neutral	-1.34	neutral	0.46	neutral_impact	-0.16	0.93	neutral	0.89	neutral	0.64	8.40	deleterious	0.73	0.75	0.61	disease	0.38	neutral	0.48	neutral	0.61	disease	2	0.91	neutral	0.55	deleterious	-6	neutral	0.18	neutral	2.09	high_impact	-0.28	medium_impact	-1.24	low_impact	0.78	0.9	23.01	21.88	0.44	N	0.04	polymorphism	1	0.01	rs386829058	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9714	9714	G	C	MI.7710	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	508	170	G	R	Ggt/Cgt	-0.33	0.22	0	probably_damaging	1	neutral	0.31	neutral	1.23	deleterious	-7.98	deleterious	-7.71	high_impact	4.7	0.63	neutral	0.02	damaging	3.95	23.60	deleterious	0.03	0.35	0.63	disease	0.92	disease	0.76	disease	0.82	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.01	medium_impact	3.03	high_impact	0.32	0.8	73.95	11.77	0.51	N	0.99	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9714	9714	G	T	MI.7711	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	508	170	G	C	Ggt/Tgt	-0.33	0.22	0	probably_damaging	1	neutral	0.16	neutral	1.24	deleterious	-7.45	deleterious	-8.68	high_impact	4.7	0.55	damaging	0.01	damaging	4.19	23.80	deleterious	0.04	0.35	0.73	disease	0.9	disease	0.65	disease	0.72	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.22	medium_impact	3.03	high_impact	0.14	0.8	73.95	11.77	0.46	N	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9715	9715	G	A	MI.7712	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	509	170	G	D	gGt/gAt	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	1.23	deleterious	-7.6	deleterious	-6.75	high_impact	4.7	0.5	damaging	0.01	damaging	3.81	23.40	deleterious	0.03	0.35	0.64	disease	0.91	disease	0.75	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.18	medium_impact	3.03	high_impact	0.15	0.8	73.95	11.77	0.56	P	0.98	polymorphism	1	0.49	.	.	.	.	.	.	COSM1155707	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9715	9715	G	T	MI.7713	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	509	170	G	V	gGt/gTt	7.3	1	0	probably_damaging	1	neutral	0.58	neutral	1.24	deleterious	-6.78	deleterious	-8.68	high_impact	4.36	0.53	damaging	0.01	damaging	3.89	23.50	deleterious	0.03	0.35	0.52	disease	0.87	disease	0.67	disease	0.74	disease	5	1	deleterious	0.29	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	0.27	medium_impact	2.73	high_impact	0.12	0.8	73.95	11.77	0.45	N	0.97	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9715	9715	G	C	MI.7714	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	509	170	G	A	gGt/gCt	7.3	1	0	probably_damaging	1	neutral	0.45	neutral	1.55	neutral	-2.65	deleterious	-5.79	medium_impact	2.4	0.45	damaging	0.02	damaging	3.19	22.70	deleterious	0.07	0.35	0.15	neutral	0.48	neutral	0.39	neutral	0.4	neutral	2	1	deleterious	0.23	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	0.14	medium_impact	0.97	medium_impact	0.24	0.8	73.95	11.77	0.44	N	0.30	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9717	9717	C	A	MI.7715	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	511	171	L	I	Ctc/Atc	-14.22	0	0	benign	0	neutral	0.37	neutral	2.29	neutral	-0.97	neutral	0.36	neutral_impact	0.42	0.8	neutral	0.98	neutral	0.21	4.77	deleterious	0.36	0.5	0.2	neutral	0.09	neutral	0.17	neutral	0.3	neutral	4	0.63	neutral	0.69	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.06	medium_impact	-0.81	medium_impact	0.55	0.8	18.39	27.73	0.55	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9717	9717	C	T	MI.7716	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	511	171	L	F	Ctc/Ttc	-14.22	0	0	benign	0.08	neutral	0.97	neutral	2.18	neutral	-1.86	neutral	-2.03	low_impact	1.09	0.7	neutral	0.85	neutral	0.49	7.39	deleterious	0.2	0.45	0.27	neutral	0.34	neutral	0.27	neutral	0.45	neutral	1	0.03	neutral	0.95	deleterious	-6	neutral	0.15	neutral	0.16	medium_impact	1.05	medium_impact	-0.21	medium_impact	0.45	0.8	18.39	27.73	0.35	N	0.41	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9717	9717	C	G	MI.7717	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	511	171	L	V	Ctc/Gtc	-14.22	0	0	benign	0	neutral	0.59	neutral	2.32	neutral	-0.44	neutral	0.02	neutral_impact	0.26	0.83	neutral	0.98	neutral	-0.25	0.85	neutral	0.34	0.5	0.14	neutral	0.14	neutral	0.2	neutral	0.28	neutral	4	0.41	neutral	0.8	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	0.28	medium_impact	-0.95	medium_impact	0.58	0.8	18.39	27.73	0.4	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9718	9718	T	C	MI.7718	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	512	171	L	P	cTc/cCc	-5.66	0	0	benign	0.15	neutral	0.17	neutral	2.11	deleterious	-4.11	deleterious	-4.34	medium_impact	2.79	0.55	damaging	0.3	neutral	2.09	16.76	deleterious	0.03	0.35	0.55	disease	0.86	disease	0.63	disease	0.76	disease	5	0.8	neutral	0.51	deleterious	-3	neutral	0.32	neutral	-0.14	medium_impact	-0.2	medium_impact	1.32	medium_impact	0.22	0.8	18.39	27.73	0.31	N	0.76	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9718	9718	T	A	MI.7719	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	512	171	L	H	cTc/cAc	-5.66	0	0	possibly_damaging	0.53	neutral	0.45	neutral	2.11	deleterious	-4.18	deleterious	-4.49	high_impact	3.59	0.68	neutral	0.46	neutral	3.79	23.40	deleterious	0.05	0.35	0.54	disease	0.65	disease	0.58	disease	0.69	disease	4	0.56	neutral	0.46	neutral	1	deleterious	0.42	neutral	-0.92	medium_impact	0.14	medium_impact	2.04	high_impact	0.19	0.8	18.39	27.73	0.32	N	0.55	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8889	8889	T	G	MI.772	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	363	121	I	M	atT/atG	1.75	0.12	0	benign	0	neutral	0.09	neutral	4.38	neutral	-1.34	neutral	0.46	neutral_impact	-0.16	0.93	neutral	0.89	neutral	0.40	6.64	deleterious	0.73	0.75	0.61	disease	0.38	neutral	0.48	neutral	0.61	disease	2	0.91	neutral	0.55	deleterious	-6	neutral	0.18	neutral	2.09	high_impact	-0.28	medium_impact	-1.24	low_impact	0.78	0.9	23.01	21.88	0.44	N	0.04	polymorphism	1	0.01	rs386829058	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9718	9718	T	G	MI.7720	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	512	171	L	R	cTc/cGc	-5.66	0	0	benign	0.15	neutral	0.29	neutral	2.12	deleterious	-3.61	deleterious	-4.13	high_impact	3.59	0.61	neutral	0.39	neutral	2.39	18.74	deleterious	0.02	0.35	0.44	neutral	0.83	disease	0.63	disease	0.75	disease	5	0.66	neutral	0.57	deleterious	-2	neutral	0.30	neutral	-0.14	medium_impact	-0.03	medium_impact	2.04	high_impact	0.17	0.8	18.39	27.73	0.39	N	0.62	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9720	9720	T	C	MI.7721	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	514	172	Y	H	Tat/Cat	-11.44	0	0	probably_damaging	1	neutral	0.16	neutral	2.19	neutral	-2.87	deleterious	-4.68	high_impact	4.16	0.57	damaging	0.03	damaging	1.71	14.44	neutral	0.22	0.45	0.43	neutral	0.84	disease	0.69	disease	0.72	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	-0.22	medium_impact	2.55	high_impact	0.24	0.8	73.95	11.67	0.33	N	0.97	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9720	9720	T	G	MI.7722	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	514	172	Y	D	Tat/Gat	-11.44	0	0	probably_damaging	1	neutral	0.06	neutral	2.19	neutral	-2.96	deleterious	-9.3	high_impact	4.16	0.63	neutral	0.02	damaging	3.92	23.50	deleterious	0.08	0.35	0.5	neutral	0.91	disease	0.69	disease	0.75	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.49	medium_impact	2.55	high_impact	0.23	0.8	73.95	11.67	0.39	N	0.99	disease_causing	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9720	9720	T	A	MI.7723	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	514	172	Y	N	Tat/Aat	-11.44	0	0	probably_damaging	1	neutral	0.09	neutral	2.2	neutral	-2.42	deleterious	-8.37	high_impact	3.82	0.6	damaging	0.02	damaging	3.96	23.60	deleterious	0.15	0.45	0.38	neutral	0.87	disease	0.61	disease	0.71	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	-0.38	medium_impact	2.24	high_impact	0.26	0.8	73.95	11.67	0.35	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9721	9721	A	C	MI.7724	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	515	172	Y	S	tAt/tCt	7.53	1	0	probably_damaging	0.99	neutral	0.11	neutral	2.23	neutral	-1.42	deleterious	-8.31	medium_impact	2.88	0.61	neutral	0.04	damaging	3.74	23.30	deleterious	0.12	0.4	0.23	neutral	0.82	disease	0.59	disease	0.64	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.74	deleterious	-2.81	low_impact	-0.33	medium_impact	1.4	medium_impact	0.29	0.8	73.95	11.67	0.41	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9721	9721	A	T	MI.7725	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	515	172	Y	F	tAt/tTt	7.53	1	0	probably_damaging	0.96	neutral	0.71	neutral	2.23	neutral	-1.3	deleterious	-3.64	medium_impact	2.31	0.53	damaging	0.05	damaging	3.44	23.00	deleterious	0.28	0.45	0.24	neutral	0.76	disease	0.41	neutral	0.51	disease	0	0.96	neutral	0.38	neutral	1	deleterious	0.71	deleterious	-2.21	low_impact	0.41	medium_impact	0.89	medium_impact	0.41	0.8	73.95	11.67	0.42	N	0.72	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9721	9721	A	G	MI.7726	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	515	172	Y	C	tAt/tGt	7.53	1	0	probably_damaging	1	neutral	0.12	neutral	2.19	neutral	-2.88	deleterious	-8.29	medium_impact	2.53	0.61	neutral	0.03	damaging	3.61	23.20	deleterious	0.1	0.4	0.24	neutral	0.88	disease	0.58	disease	0.66	disease	3	1	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	-0.3	medium_impact	1.09	medium_impact	0.07	0.8	73.95	11.67	0.37	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9723	9723	T	G	MI.7727	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	517	173	F	V	Ttt/Gtt	-3.11	0	0	probably_damaging	1	neutral	0.33	neutral	0.63	deleterious	-7.79	deleterious	-6.75	high_impact	4.8	0.66	neutral	0.02	damaging	4.22	23.90	deleterious	0.04	0.35	0.67	disease	0.87	disease	0.75	disease	0.78	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	0.02	medium_impact	3.12	high_impact	0.16	0.8	73.95	11.66	0.6	P	0.97	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9723	9723	T	C	MI.7728	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	517	173	F	L	Ttt/Ctt	-3.11	0	0	probably_damaging	0.98	neutral	0.52	neutral	0.66	deleterious	-6.34	deleterious	-5.78	high_impact	4.45	0.64	neutral	0.03	damaging	4.25	23.90	deleterious	0.04	0.35	0.56	disease	0.87	disease	0.7	disease	0.73	disease	5	0.98	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-2.51	low_impact	0.21	medium_impact	2.81	high_impact	0.39	0.8	73.95	11.66	0.37	N	0.92	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9723	9723	T	A	MI.7729	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	517	173	F	I	Ttt/Att	-3.11	0	0	probably_damaging	0.99	neutral	0.24	neutral	0.63	deleterious	-7.6	deleterious	-5.78	high_impact	4.8	0.69	neutral	0.02	damaging	4.73	24.60	deleterious	0.06	0.35	0.69	disease	0.83	disease	0.74	disease	0.76	disease	5	0.99	deleterious	0.13	neutral	2	deleterious	0.81	deleterious	-2.81	low_impact	-0.09	medium_impact	3.12	high_impact	0.24	0.8	73.95	11.66	0.61	P	0.96	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8890	8890	A	C	MI.773	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	364	122	K	Q	Aaa/Caa	-20	0	0	probably_damaging	1	neutral	0.51	neutral	4.38	neutral	-0.26	neutral	-2.26	low_impact	1.26	0.87	neutral	0.18	damaging	3.46	23.00	deleterious	0.48	0.65	0.61	disease	0.49	neutral	0.34	neutral	0.52	disease	0	0.99	deleterious	0.26	neutral	-2	neutral	0.78	deleterious	-3.6	low_impact	0.3	medium_impact	-0.02	medium_impact	0.66	0.9	47.35	8.39	0.25	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9724	9724	T	C	MI.7730	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	518	173	F	S	tTt/tCt	7.3	1	0	probably_damaging	1	neutral	0.14	neutral	0.62	deleterious	-8.52	deleterious	-7.71	high_impact	4.45	0.56	damaging	0.02	damaging	4.29	24.00	deleterious	0.02	0.35	0.61	disease	0.85	disease	0.69	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.26	medium_impact	2.81	high_impact	0.13	0.8	73.95	11.66	0.46	N	0.96	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9724	9724	T	G	MI.7731	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	518	173	F	C	tTt/tGt	7.3	1	0	probably_damaging	1	neutral	0.09	neutral	0.62	deleterious	-9.7	deleterious	-7.71	high_impact	4.8	0.72	neutral	0.02	damaging	4.16	23.80	deleterious	0.02	0.35	0.89	disease	0.86	disease	0.75	disease	0.81	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.38	medium_impact	3.12	high_impact	0.09	0.8	73.95	11.66	0.59	P	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9724	9724	T	A	MI.7732	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	518	173	F	Y	tTt/tAt	7.3	1	0	probably_damaging	0.98	neutral	0.73	neutral	0.79	deleterious	-4.49	deleterious	-2.89	high_impact	4.45	0.71	neutral	0.03	damaging	4.25	23.90	deleterious	0.09	0.4	0.45	neutral	0.8	disease	0.7	disease	0.7	disease	4	0.98	deleterious	0.38	neutral	2	deleterious	0.78	deleterious	-2.51	low_impact	0.44	medium_impact	2.81	high_impact	0.36	0.8	73.95	11.66	0.53	N	0.80	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9725	9725	T	G	MI.7733	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	519	173	F	L	ttT/ttG	7.3	1	0	probably_damaging	0.98	neutral	0.52	neutral	0.66	deleterious	-6.34	deleterious	-5.78	high_impact	4.45	0.64	neutral	0.03	damaging	4.30	24.00	deleterious	0.04	0.35	0.56	disease	0.87	disease	0.7	disease	0.73	disease	5	0.98	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-2.51	low_impact	0.21	medium_impact	2.81	high_impact	0.39	0.8	73.95	11.66	0.53	N	0.92	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9725	9725	T	A	MI.7734	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	519	173	F	L	ttT/ttA	7.3	1	0	probably_damaging	0.98	neutral	0.52	neutral	0.66	deleterious	-6.34	deleterious	-5.78	high_impact	4.45	0.64	neutral	0.03	damaging	4.44	24.20	deleterious	0.04	0.35	0.56	disease	0.87	disease	0.7	disease	0.73	disease	5	0.98	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-2.51	low_impact	0.21	medium_impact	2.81	high_impact	0.39	0.8	73.95	11.66	0.54	N	0.92	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9726	9726	A	C	MI.7735	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	520	174	T	P	Acc/Ccc	-6.58	0	0	probably_damaging	0.99	neutral	0.15	neutral	2.46	neutral	-2.73	deleterious	-5.11	high_impact	4.34	0.63	neutral	0.05	damaging	3.54	23.10	deleterious	0.04	0.35	0.55	disease	0.91	disease	0.72	disease	0.78	disease	6	0.99	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-2.81	low_impact	-0.24	medium_impact	2.71	high_impact	0.31	0.8	73.56	11.63	0.36	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9726	9726	A	T	MI.7736	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	520	174	T	S	Acc/Tcc	-6.58	0	0	probably_damaging	0.91	neutral	0.36	neutral	2.5	neutral	-0.74	deleterious	-2.67	low_impact	1.8	0.5	damaging	0.12	damaging	2.21	17.57	deleterious	0.37	0.5	0.33	neutral	0.51	disease	0.36	neutral	0.43	neutral	1	0.92	neutral	0.23	neutral	-2	neutral	0.68	deleterious	-1.85	low_impact	0.05	medium_impact	0.43	medium_impact	0.52	0.8	73.56	11.63	0.31	N	0.77	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9726	9726	A	G	MI.7737	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	520	174	T	A	Acc/Gcc	-6.58	0	0	probably_damaging	0.91	neutral	0.43	neutral	2.51	neutral	-0.19	deleterious	-3.98	medium_impact	3.37	0.64	neutral	0.04	damaging	3.54	23.10	deleterious	0.22	0.45	0.19	neutral	0.71	disease	0.59	disease	0.65	disease	3	0.91	neutral	0.26	neutral	1	deleterious	0.67	deleterious	-1.85	low_impact	0.12	medium_impact	1.84	medium_impact	0.27	0.8	73.56	11.63	0.26	N	0.44	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9727	9727	C	T	MI.7738	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	521	174	T	I	aCc/aTc	6.84	1	0	probably_damaging	0.99	neutral	0.43	neutral	2.56	neutral	0.4	deleterious	-5.28	medium_impact	2.61	0.63	neutral	0.02	damaging	4.03	23.60	deleterious	0.1	0.4	0.16	neutral	0.88	disease	0.51	disease	0.66	disease	3	0.99	deleterious	0.22	neutral	1	deleterious	0.73	deleterious	-2.81	low_impact	0.12	medium_impact	1.16	medium_impact	0.50	0.8	73.56	11.63	0.34	N	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9727	9727	C	G	MI.7739	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	521	174	T	S	aCc/aGc	6.84	1	0	probably_damaging	0.91	neutral	0.36	neutral	2.5	neutral	-0.74	deleterious	-2.67	low_impact	1.8	0.5	damaging	0.12	damaging	2.46	19.18	deleterious	0.37	0.5	0.33	neutral	0.51	disease	0.36	neutral	0.43	neutral	1	0.92	neutral	0.23	neutral	-2	neutral	0.68	deleterious	-1.85	low_impact	0.05	medium_impact	0.43	medium_impact	0.52	0.8	73.56	11.63	0.52	P	0.77	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8890	8890	A	G	MI.774	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	364	122	K	E	Aaa/Gaa	-20	0	0	probably_damaging	0.99	neutral	0.45	neutral	4.4	neutral	0.18	neutral	-2.25	low_impact	1.93	0.88	neutral	0.17	damaging	4.03	23.70	deleterious	0.46	0.65	0.71	disease	0.75	disease	0.67	disease	0.64	disease	3	0.99	deleterious	0.23	neutral	-2	neutral	0.85	deleterious	-2.65	low_impact	0.24	medium_impact	0.56	medium_impact	0.68	0.9	47.35	8.39	0.22	N	0.85	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	A8890G	Juvenile-onset metabolic syndrome	-	+	Reported	1	.	P	P	damaging
chrM	9727	9727	C	A	MI.7740	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	521	174	T	N	aCc/aAc	6.84	1	0	probably_damaging	0.99	neutral	0.23	neutral	2.45	neutral	-2.56	deleterious	-3.98	high_impact	4	0.66	neutral	0.02	damaging	3.71	23.30	deleterious	0.27	0.45	0.49	neutral	0.89	disease	0.61	disease	0.7	disease	4	0.99	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-2.81	low_impact	-0.11	medium_impact	2.4	high_impact	0.50	0.8	73.56	11.63	0.48	N	0.89	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9729	9729	C	A	MI.7741	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	523	175	L	I	Ctc/Atc	-10.51	0	0	probably_damaging	0.93	neutral	0.48	neutral	2.56	neutral	-0.26	neutral	-0.01	neutral_impact	0.68	0.84	neutral	0.77	neutral	0.46	7.16	deleterious	0.32	0.5	0.14	neutral	0.11	neutral	0.19	neutral	0.29	neutral	4	0.93	neutral	0.28	neutral	-2	neutral	0.49	deleterious	-1.96	low_impact	0.17	medium_impact	-0.57	medium_impact	0.63	0.8	22.99	37.57	0.44	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9729	9729	C	G	MI.7742	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	523	175	L	V	Ctc/Gtc	-10.51	0	0	possibly_damaging	0.83	neutral	0.36	neutral	2.59	neutral	0.52	neutral	0.09	neutral_impact	0.74	0.77	neutral	0.8	neutral	-0.31	0.62	neutral	0.28	0.45	0.13	neutral	0.24	neutral	0.25	neutral	0.41	neutral	2	0.85	neutral	0.27	neutral	-3	neutral	0.49	deleterious	-1.54	low_impact	0.05	medium_impact	-0.52	medium_impact	0.61	0.8	22.99	37.57	0.38	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9729	9729	C	T	MI.7743	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	523	175	L	F	Ctc/Ttc	-10.51	0	0	probably_damaging	0.97	neutral	0.81	neutral	2.51	neutral	-0.92	neutral	-0.88	neutral_impact	0.34	0.79	neutral	0.86	neutral	0.06	3.21	deleterious	0.27	0.45	0.23	neutral	0.27	neutral	0.2	neutral	0.43	neutral	1	0.97	neutral	0.42	neutral	-2	neutral	0.63	deleterious	-2.34	low_impact	0.55	medium_impact	-0.88	medium_impact	0.59	0.8	22.99	37.57	0.31	N	0.49	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9730	9730	T	G	MI.7744	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	524	175	L	R	cTc/cGc	-0.1	0	0	probably_damaging	0.99	neutral	0.31	neutral	2.46	neutral	-2.72	neutral	-2.04	medium_impact	2.69	0.64	neutral	0.36	neutral	2.31	18.23	deleterious	0.02	0.35	0.33	neutral	0.75	disease	0.51	disease	0.59	disease	2	0.99	deleterious	0.16	neutral	1	deleterious	0.75	deleterious	-2.81	low_impact	-0.01	medium_impact	1.23	medium_impact	0.32	0.8	22.99	37.57	0.32	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9730	9730	T	A	MI.7745	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	524	175	L	H	cTc/cAc	-0.1	0	0	probably_damaging	0.99	neutral	0.38	neutral	2.45	deleterious	-3.3	neutral	-2.46	medium_impact	3.25	0.74	neutral	0.39	neutral	2.14	17.12	deleterious	0.04	0.35	0.43	neutral	0.55	disease	0.44	neutral	0.48	neutral	0	0.99	deleterious	0.2	neutral	1	deleterious	0.71	deleterious	-2.81	low_impact	0.07	medium_impact	1.73	medium_impact	0.31	0.8	22.99	37.57	0.37	N	0.84	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9730	9730	T	C	MI.7746	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	524	175	L	P	cTc/cCc	-0.1	0	0	probably_damaging	1	neutral	0.14	neutral	2.45	deleterious	-3.36	neutral	-2.31	medium_impact	3.25	0.55	damaging	0.26	damaging	2.48	19.33	deleterious	0.02	0.35	0.45	neutral	0.81	disease	0.54	disease	0.73	disease	5	1	deleterious	0.07	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	-0.26	medium_impact	1.73	medium_impact	0.38	0.8	22.99	37.57	0.33	N	0.93	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9732	9732	C	A	MI.7747	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	526	176	L	M	Cta/Ata	-8.66	0	0	possibly_damaging	0.78	neutral	0.2	neutral	2.12	neutral	-1.44	neutral	-1.89	medium_impact	2.8	0.53	damaging	0.03	damaging	3.74	23.30	deleterious	0.24	0.45	0.36	neutral	0.56	disease	0.48	neutral	0.47	neutral	1	0.87	neutral	0.21	neutral	0	NA	0.58	deleterious	-1.4	low_impact	-0.15	medium_impact	1.33	medium_impact	0.61	0.8	73.95	11.53	0.32	N	0.85	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9732	9732	C	G	MI.7748	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	526	176	L	V	Cta/Gta	-8.66	0	0	benign	0	neutral	0.28	neutral	2.25	neutral	-0.31	deleterious	-2.76	medium_impact	2.33	0.51	damaging	0.03	damaging	1.54	13.53	neutral	0.23	0.45	0.16	neutral	0.51	disease	0.51	disease	0.42	neutral	2	0.72	neutral	0.64	deleterious	-3	neutral	0.15	neutral	2.05	high_impact	-0.04	medium_impact	0.91	medium_impact	0.54	0.8	73.95	11.53	0.35	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9733	9733	T	G	MI.7749	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	527	176	L	R	cTa/cGa	1.05	0.43	0	possibly_damaging	0.83	neutral	0.19	neutral	2.09	deleterious	-3.56	deleterious	-5.75	high_impact	4.38	0.67	neutral	0.02	damaging	4.21	23.90	deleterious	0.03	0.35	0.47	neutral	0.9	disease	0.71	disease	0.78	disease	6	0.9	neutral	0.18	neutral	1	deleterious	0.77	deleterious	-1.54	low_impact	-0.17	medium_impact	2.74	high_impact	0.25	0.8	73.95	11.53	0.38	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8891	8891	A	C	MI.775	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	365	122	K	T	aAa/aCa	3.83	0.99	0	probably_damaging	0.99	neutral	1	neutral	4.42	neutral	0.51	neutral	-1.47	neutral_impact	-0.86	0.74	neutral	0.39	neutral	0.94	10.30	neutral	0.34	0.65	0.51	disease	0.14	neutral	0.24	neutral	0.23	neutral	5	0.99	deleterious	0.51	deleterious	-2	neutral	0.72	deleterious	-2.65	low_impact	1.98	high_impact	-1.83	low_impact	0.53	0.9	47.35	8.39	0.36	N	0.81	polymorphism	0.84	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9733	9733	T	A	MI.7750	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	527	176	L	Q	cTa/cAa	1.05	0.43	0	possibly_damaging	0.88	neutral	0.44	neutral	2.09	deleterious	-3.73	deleterious	-5.75	high_impact	4.38	0.61	neutral	0.02	damaging	4.10	23.70	deleterious	0.06	0.35	0.49	neutral	0.8	disease	0.58	disease	0.66	disease	3	0.87	neutral	0.28	neutral	1	deleterious	0.73	deleterious	-1.71	low_impact	0.13	medium_impact	2.74	high_impact	0.33	0.8	73.95	11.53	0.34	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9733	9733	T	C	MI.7751	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	527	176	L	P	cTa/cCa	1.05	0.43	0	probably_damaging	0.94	neutral	0.11	neutral	2.07	deleterious	-3.95	deleterious	-6.68	high_impact	3.83	0.55	damaging	0.03	damaging	3.94	23.60	deleterious	0.03	0.35	0.57	disease	0.86	disease	0.71	disease	0.76	disease	5	0.98	neutral	0.09	neutral	2	deleterious	0.82	deleterious	-2.03	low_impact	-0.33	medium_impact	2.25	high_impact	0.29	0.8	73.95	11.53	0.32	N	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9735	9735	C	G	MI.7752	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	529	177	Q	E	Caa/Gaa	-13.06	0	0	probably_damaging	0.95	neutral	0.31	neutral	2.18	neutral	-1.6	deleterious	-2.89	high_impact	3.81	0.77	neutral	0.01	damaging	3.20	22.70	deleterious	0.13	0.4	0.2	neutral	0.73	disease	0.77	disease	0.72	disease	4	0.96	neutral	0.18	neutral	2	deleterious	0.72	deleterious	-2.11	low_impact	-0.01	medium_impact	2.23	high_impact	0.43	0.8	74.33	11.67	0.36	N	0.95	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9735	9735	C	A	MI.7753	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	529	177	Q	K	Caa/Aaa	-13.06	0	0	probably_damaging	1	neutral	0.29	neutral	2.16	neutral	-1.74	deleterious	-3.86	high_impact	3.81	0.76	neutral	0.01	damaging	4.04	23.70	deleterious	0.09	0.35	0.19	neutral	0.84	disease	0.77	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	-0.03	medium_impact	2.23	high_impact	0.40	0.8	74.33	11.67	0.36	N	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9736	9736	A	T	MI.7754	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	530	177	Q	L	cAa/cTa	4.52	1	0	probably_damaging	1	neutral	0.68	neutral	1.96	deleterious	-4.83	deleterious	-6.75	high_impact	4.24	0.64	neutral	0.02	damaging	3.72	23.30	deleterious	0.03	0.35	0.52	disease	0.9	disease	0.69	disease	0.72	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.38	medium_impact	2.62	high_impact	0.20	0.8	74.33	11.67	0.46	N	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9736	9736	A	C	MI.7755	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	530	177	Q	P	cAa/cCa	4.52	1	0	probably_damaging	0.99	neutral	0.2	neutral	1.96	deleterious	-5.23	deleterious	-5.79	high_impact	4.79	0.71	neutral	0.04	damaging	3.28	22.80	deleterious	0.03	0.35	0.6	disease	0.87	disease	0.81	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.15	medium_impact	3.11	high_impact	0.30	0.8	74.33	11.67	0.67	P	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9736	9736	A	G	MI.7756	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	530	177	Q	R	cAa/cGa	4.52	1	0	probably_damaging	1	neutral	0.34	neutral	2.02	deleterious	-3.18	deleterious	-3.86	high_impact	4.79	0.84	neutral	0.02	damaging	3.44	23.00	deleterious	0.09	0.35	0.32	neutral	0.87	disease	0.79	disease	0.74	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	0.03	medium_impact	3.11	high_impact	0.28	0.8	74.33	11.67	0.71	P	0.98	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9737	9737	A	C	MI.7757	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	531	177	Q	H	caA/caC	8.69	1	0	probably_damaging	1	neutral	0.54	neutral	1.96	deleterious	-5.31	deleterious	-4.82	high_impact	4.09	0.63	neutral	0.01	damaging	3.52	23.10	deleterious	0.07	0.35	0.4	neutral	0.81	disease	0.77	disease	0.74	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	0.23	medium_impact	2.48	high_impact	0.56	0.8	74.33	11.67	0.53	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9737	9737	A	T	MI.7758	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	531	177	Q	H	caA/caT	8.69	1	0	probably_damaging	1	neutral	0.54	neutral	1.96	deleterious	-5.31	deleterious	-4.82	high_impact	4.09	0.63	neutral	0.01	damaging	3.70	23.30	deleterious	0.07	0.35	0.4	neutral	0.81	disease	0.77	disease	0.74	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	0.23	medium_impact	2.48	high_impact	0.56	0.8	74.33	11.67	0.55	P	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9738	9738	G	A	MI.7759	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	532	178	A	T	Gcc/Acc	0.82	0.99	0	benign	0.06	neutral	0.38	neutral	2.48	neutral	-1.93	deleterious	-2.83	medium_impact	3.39	0.63	neutral	0.59	neutral	2.45	19.14	deleterious	0.16	0.45	0.18	neutral	0.68	disease	0.38	neutral	0.49	neutral	0	0.58	neutral	0.66	deleterious	-3	neutral	0.23	neutral	0.29	medium_impact	0.07	medium_impact	1.86	medium_impact	0.72	0.85	21.07	51.57	0.55	P	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8891	8891	A	T	MI.776	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	365	122	K	M	aAa/aTa	3.83	0.99	0	probably_damaging	1	neutral	0.15	neutral	4.38	neutral	-0.34	deleterious	-3.44	low_impact	1.45	0.87	neutral	0.15	damaging	4.02	23.60	deleterious	0.28	0.65	0.73	disease	0.55	disease	0.6	disease	0.68	disease	4	1	deleterious	0.08	neutral	-2	neutral	0.79	deleterious	-3.6	low_impact	-0.13	medium_impact	0.15	medium_impact	0.51	0.9	47.35	8.39	0.47	N	0.53	polymorphism	0.69	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9738	9738	G	T	MI.7760	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	532	178	A	S	Gcc/Tcc	0.82	0.99	0	benign	0.06	neutral	0.39	neutral	2.47	neutral	-2.22	neutral	-2.24	medium_impact	2.62	0.65	neutral	0.52	neutral	1.93	15.79	deleterious	0.19	0.45	0.2	neutral	0.72	disease	0.36	neutral	0.5	disease	0	0.57	neutral	0.67	deleterious	-3	neutral	0.21	neutral	0.29	medium_impact	0.08	medium_impact	1.17	medium_impact	0.57	0.8	21.07	51.57	0.6	P	0.44	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	G9738T	LHON	+	-	Reported	1	.	P	P	damaging
chrM	9738	9738	G	C	MI.7761	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	532	178	A	P	Gcc/Ccc	0.82	0.99	0	benign	0.39	neutral	0.2	neutral	2.44	deleterious	-4.17	deleterious	-3.88	high_impact	3.94	0.54	damaging	0.33	neutral	3.58	23.20	deleterious	0.03	0.35	0.48	neutral	0.9	disease	0.62	disease	0.73	disease	5	0.76	neutral	0.41	neutral	-2	neutral	0.62	deleterious	-0.68	medium_impact	-0.15	medium_impact	2.35	high_impact	0.64	0.8	21.07	51.57	0.45	N	0.97	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9739	9739	C	A	MI.7762	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	533	178	A	D	gCc/gAc	2.44	0.99	0	benign	0.3	neutral	0.2	neutral	2.43	deleterious	-4.59	deleterious	-4.71	high_impact	3.6	0.55	damaging	0.36	neutral	4.32	24.00	deleterious	0.02	0.35	0.44	neutral	0.9	disease	0.62	disease	0.73	disease	5	0.76	neutral	0.45	neutral	-2	neutral	0.51	deleterious	-0.51	medium_impact	-0.15	medium_impact	2.04	high_impact	0.48	0.8	21.07	51.57	0.46	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9739	9739	C	T	MI.7763	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	533	178	A	V	gCc/gTc	2.44	0.99	0	benign	0	neutral	0.5	neutral	2.59	neutral	-0.27	neutral	-2.4	low_impact	1.44	0.66	neutral	0.67	neutral	2.47	19.24	deleterious	0.16	0.45	0.14	neutral	0.7	disease	0.28	neutral	0.48	neutral	0	0.49	neutral	0.75	deleterious	-6	neutral	0.15	neutral	2.05	high_impact	0.19	medium_impact	0.11	medium_impact	0.74	0.85	21.07	51.57	0.47	N	0.51	polymorphism	1	0.08	rs879159866	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9739	9739	C	G	MI.7764	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	533	178	A	G	gCc/gGc	2.44	0.99	0	benign	0.04	neutral	0.33	neutral	2.51	neutral	-1.34	deleterious	-2.98	neutral_impact	0.7	0.67	neutral	0.7	neutral	1.04	10.90	neutral	0.23	0.45	0.21	neutral	0.44	neutral	0.22	neutral	0.44	neutral	1	0.65	neutral	0.65	deleterious	-6	neutral	0.16	neutral	0.47	medium_impact	0.02	medium_impact	-0.56	medium_impact	0.77	0.85	21.07	51.57	0.53	P	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9741	9741	T	G	MI.7765	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	535	179	S	A	Tca/Gca	-5.19	0	0	possibly_damaging	0.84	neutral	0.53	neutral	2.61	neutral	0.44	neutral	-0.48	low_impact	0.86	0.68	neutral	0.66	neutral	2.44	19.07	deleterious	0.22	0.45	0.15	neutral	0.25	neutral	0.32	neutral	0.43	neutral	1	0.82	neutral	0.35	neutral	-3	neutral	0.42	neutral	-1.57	low_impact	0.22	medium_impact	-0.41	medium_impact	0.44	0.8	24.14	20.87	0.3	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9741	9741	T	C	MI.7766	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	535	179	S	P	Tca/Cca	-5.19	0	0	probably_damaging	0.96	neutral	0.19	neutral	2.55	neutral	-1.05	neutral	-1.83	medium_impact	1.96	0.48	damaging	0.25	damaging	2.92	22.00	deleterious	0.09	0.35	0.39	neutral	0.81	disease	0.49	neutral	0.69	disease	4	0.97	neutral	0.12	neutral	1	deleterious	0.77	deleterious	-2.21	low_impact	-0.17	medium_impact	0.57	medium_impact	0.32	0.8	24.14	20.87	0.39	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9741	9741	T	A	MI.7767	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	535	179	S	T	Tca/Aca	-5.19	0	0	possibly_damaging	0.74	neutral	0.37	neutral	2.61	neutral	0.51	neutral	-0.37	neutral_impact	0.33	0.7	neutral	0.69	neutral	2.46	19.19	deleterious	0.19	0.45	0.14	neutral	0.25	neutral	0.33	neutral	0.42	neutral	2	0.76	neutral	0.32	neutral	-3	neutral	0.50	deleterious	-1.31	low_impact	0.06	medium_impact	-0.89	medium_impact	0.50	0.8	24.14	20.87	0.37	N	0.61	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9742	9742	C	T	MI.7768	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	536	179	S	L	tCa/tTa	4.06	0.87	0	probably_damaging	0.97	neutral	0.66	neutral	2.69	neutral	1.55	neutral	0.21	neutral_impact	-0.72	0.73	neutral	0.72	neutral	2.99	22.20	deleterious	0.11	0.4	0.11	neutral	0.47	neutral	0.26	neutral	0.42	neutral	2	0.97	neutral	0.35	neutral	-2	neutral	0.65	deleterious	-2.34	low_impact	0.36	medium_impact	-1.83	low_impact	0.41	0.8	24.14	20.87	0.36	N	0.93	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9742	9742	C	G	MI.7769	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	536	179	S	W	tCa/tGa	4.06	0.87	0	probably_damaging	1	neutral	0.17	neutral	2.62	neutral	0.64	neutral	1.18	neutral_impact	0.44	0.69	neutral	0.62	neutral	3.19	22.70	deleterious	0.07	0.35	0.54	disease	0.7	disease	0.35	neutral	0.52	disease	0	1	deleterious	0.09	neutral	-2	neutral	0.76	deleterious	-3.78	low_impact	-0.2	medium_impact	-0.79	medium_impact	0.18	0.8	24.14	20.87	0.37	N	1.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8892	8892	A	T	MI.777	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	366	122	K	N	aaA/aaT	6.14	1	0	probably_damaging	1	neutral	0.77	neutral	4.41	neutral	0.41	neutral	-2.43	neutral_impact	0.02	0.87	neutral	0.16	damaging	2.53	19.66	deleterious	0.59	0.7	0.76	disease	0.46	neutral	0.32	neutral	0.64	disease	3	0.99	deleterious	0.39	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.59	medium_impact	-1.08	low_impact	0.80	0.9	47.35	8.39	0.44	N	0.76	polymorphism	0.68	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9744	9744	G	C	MI.7770	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	538	180	E	Q	Gag/Cag	-0.33	0.34	0	probably_damaging	0.98	neutral	0.24	neutral	1.2	deleterious	-5.81	deleterious	-2.89	high_impact	4.78	0.55	damaging	0.52	neutral	3.45	23.00	deleterious	0.07	0.35	0.77	disease	0.79	disease	0.78	disease	0.77	disease	5	0.99	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-2.51	low_impact	-0.09	medium_impact	3.1	high_impact	0.59	0.8	73.18	11.71	0.7	P	0.87	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9744	9744	G	A	MI.7771	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	538	180	E	K	Gag/Aag	-0.33	0.34	0	probably_damaging	0.98	neutral	0.2	neutral	1.2	deleterious	-5.7	deleterious	-3.86	high_impact	4.08	0.43	damaging	0.29	neutral	4.55	24.30	deleterious	0.03	0.35	0.73	disease	0.87	disease	0.76	disease	0.77	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-2.51	low_impact	-0.15	medium_impact	2.47	high_impact	0.77	0.85	73.18	11.71	0.57	P	0.97	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9745	9745	A	T	MI.7772	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	539	180	E	V	gAg/gTg	7.3	1	0	probably_damaging	0.99	neutral	0.37	neutral	1.17	deleterious	-7.52	deleterious	-6.75	high_impact	4.42	0.46	damaging	0.46	neutral	4.22	23.90	deleterious	0.02	0.35	0.87	disease	0.89	disease	0.78	disease	0.83	disease	7	0.99	deleterious	0.19	neutral	2	deleterious	0.87	deleterious	-2.81	low_impact	0.06	medium_impact	2.78	high_impact	0.28	0.8	73.18	11.71	0.66	P	0.83	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9745	9745	A	G	MI.7773	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	539	180	E	G	gAg/gGg	7.3	1	0	probably_damaging	0.99	neutral	0.25	neutral	1.18	deleterious	-6.65	deleterious	-6.74	high_impact	4.78	0.46	damaging	0.57	neutral	4.19	23.80	deleterious	0.03	0.35	0.77	disease	0.82	disease	0.75	disease	0.77	disease	5	0.99	deleterious	0.13	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.08	medium_impact	3.1	high_impact	0.11	0.8	73.18	11.71	0.68	P	0.62	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9745	9745	A	C	MI.7774	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	539	180	E	A	gAg/gCg	7.3	1	0	probably_damaging	0.98	neutral	0.44	neutral	1.25	deleterious	-4.62	deleterious	-5.78	high_impact	4.42	0.56	damaging	0.53	neutral	3.63	23.20	deleterious	0.03	0.35	0.76	disease	0.73	disease	0.75	disease	0.76	disease	5	0.98	deleterious	0.23	neutral	2	deleterious	0.83	deleterious	-2.51	low_impact	0.13	medium_impact	2.78	high_impact	0.27	0.8	73.18	11.71	0.62	P	0.66	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9746	9746	G	T	MI.7775	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	540	180	E	D	gaG/gaT	8.69	1	0	probably_damaging	0.92	neutral	0.14	neutral	1.31	deleterious	-3.94	deleterious	-2.89	high_impact	4.78	0.51	damaging	0.49	neutral	3.89	23.50	deleterious	0.11	0.4	0.61	disease	0.78	disease	0.73	disease	0.74	disease	5	0.96	neutral	0.11	neutral	2	deleterious	0.77	deleterious	-1.9	low_impact	-0.26	medium_impact	3.1	high_impact	0.58	0.8	73.18	11.71	0.76	P	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9746	9746	G	C	MI.7776	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	540	180	E	D	gaG/gaC	8.69	1	0	probably_damaging	0.92	neutral	0.14	neutral	1.31	deleterious	-3.94	deleterious	-2.89	high_impact	4.78	0.51	damaging	0.49	neutral	3.76	23.30	deleterious	0.11	0.4	0.61	disease	0.78	disease	0.73	disease	0.74	disease	5	0.96	neutral	0.11	neutral	2	deleterious	0.77	deleterious	-1.9	low_impact	-0.26	medium_impact	3.1	high_impact	0.58	0.8	73.18	11.71	0.76	P	0.93	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9747	9747	T	A	MI.7777	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	541	181	Y	N	Tac/Aac	-2.19	0	0	probably_damaging	1	neutral	0.27	neutral	1.75	deleterious	-8.27	deleterious	-8.68	high_impact	4.74	0.6	neutral	0.01	damaging	4.29	24.00	deleterious	0.02	0.35	0.84	disease	0.87	disease	0.73	disease	0.8	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.06	medium_impact	3.07	high_impact	0.05	0.8	73.56	11.67	0.52	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9747	9747	T	C	MI.7778	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	541	181	Y	H	Tac/Cac	-2.19	0	0	probably_damaging	1	neutral	0.45	neutral	1.76	deleterious	-6.81	deleterious	-4.82	high_impact	4.19	0.56	damaging	0.03	damaging	3.69	23.30	deleterious	0.04	0.35	0.69	disease	0.81	disease	0.74	disease	0.75	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	0.14	medium_impact	2.57	high_impact	0.09	0.8	73.56	11.67	0.32	N	0.97	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9747	9747	T	G	MI.7779	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	541	181	Y	D	Tac/Gac	-2.19	0	0	probably_damaging	1	neutral	0.19	neutral	1.75	deleterious	-9.07	deleterious	-9.64	high_impact	4.74	0.65	neutral	0.01	damaging	4.05	23.70	deleterious	0.01	0.35	0.92	disease	0.87	disease	0.8	disease	0.86	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.17	medium_impact	3.07	high_impact	0.05	0.8	73.56	11.67	0.51	N	0.99	disease_causing	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8892	8892	A	C	MI.778	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	366	122	K	N	aaA/aaC	6.14	1	0	probably_damaging	1	neutral	0.77	neutral	4.41	neutral	0.41	neutral	-2.43	neutral_impact	0.02	0.87	neutral	0.16	damaging	2.44	19.10	deleterious	0.59	0.7	0.76	disease	0.46	neutral	0.32	neutral	0.64	disease	3	0.99	deleterious	0.39	neutral	-2	neutral	0.82	deleterious	-3.6	low_impact	0.59	medium_impact	-1.08	low_impact	0.80	0.9	47.35	8.39	0.43	N	0.76	polymorphism	0.68	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9748	9748	A	T	MI.7780	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	542	181	Y	F	tAc/tTc	7.53	1	0	probably_damaging	0.98	neutral	0.62	neutral	2.19	neutral	-1.15	deleterious	-3.86	medium_impact	3.33	0.6	damaging	0.03	damaging	3.52	23.10	deleterious	0.15	0.4	0.29	neutral	0.8	disease	0.61	disease	0.63	disease	3	0.98	deleterious	0.32	neutral	1	deleterious	0.76	deleterious	-2.51	low_impact	0.31	medium_impact	1.8	medium_impact	0.33	0.8	73.56	11.67	0.44	N	0.72	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9748	9748	A	C	MI.7781	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	542	181	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	neutral	0.42	neutral	1.75	deleterious	-7.47	deleterious	-8.68	high_impact	4.74	0.65	neutral	0.02	damaging	3.81	23.40	deleterious	0.02	0.35	0.82	disease	0.85	disease	0.73	disease	0.78	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	0.11	medium_impact	3.07	high_impact	0.06	0.8	73.56	11.67	0.6	P	0.96	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9748	9748	A	G	MI.7782	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	542	181	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	neutral	0.15	neutral	1.75	deleterious	-7.89	deleterious	-8.68	high_impact	4.74	0.68	neutral	0.02	damaging	3.62	23.20	deleterious	0.02	0.35	0.92	disease	0.87	disease	0.77	disease	0.84	disease	7	1	deleterious	0.08	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.24	medium_impact	3.07	high_impact	0.10	0.8	73.56	11.67	0.62	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9750	9750	T	A	MI.7783	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	544	182	F	I	Ttc/Atc	-1.72	0	0	benign	0	neutral	0.36	neutral	2.62	neutral	-0.16	neutral	-0.57	neutral_impact	-0.63	0.78	neutral	0.77	neutral	1.35	12.52	neutral	0.11	0.4	0.11	neutral	0.21	neutral	0.16	neutral	0.36	neutral	3	0.64	neutral	0.68	deleterious	-6	neutral	0.11	neutral	2.05	high_impact	0.05	medium_impact	-1.75	low_impact	0.60	0.8	26.05	34.16	0.47	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9750	9750	T	C	MI.7784	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	544	182	F	L	Ttc/Ctc	-1.72	0	0	benign	0.01	neutral	0.56	neutral	2.66	neutral	-0.14	neutral	-0.5	neutral_impact	0.13	0.75	neutral	0.82	neutral	1.04	10.87	neutral	0.16	0.45	0.11	neutral	0.25	neutral	0.18	neutral	0.41	neutral	2	0.42	neutral	0.78	deleterious	-6	neutral	0.11	neutral	1.07	medium_impact	0.25	medium_impact	-1.07	low_impact	0.50	0.8	26.05	34.16	0.43	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9750	9750	T	G	MI.7785	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	544	182	F	V	Ttc/Gtc	-1.72	0	0	benign	0.02	neutral	0.41	neutral	2.61	neutral	-0.34	neutral	-0.83	neutral_impact	-0.44	0.75	neutral	0.78	neutral	1.23	11.89	neutral	0.1	0.4	0.1	neutral	0.37	neutral	0.18	neutral	0.43	neutral	1	0.58	neutral	0.7	deleterious	-6	neutral	0.11	neutral	0.77	medium_impact	0.1	medium_impact	-1.58	low_impact	0.31	0.8	26.05	34.16	0.47	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9751	9751	T	G	MI.7786	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	545	182	F	C	tTc/tGc	4.52	0.99	0	possibly_damaging	0.63	neutral	0.14	neutral	2.53	deleterious	-3.33	deleterious	-2.55	low_impact	1.12	0.66	neutral	0.52	neutral	3.91	23.50	deleterious	0.07	0.35	0.38	neutral	0.59	disease	0.38	neutral	0.47	neutral	1	0.87	neutral	0.26	neutral	-3	neutral	0.54	deleterious	-1.09	low_impact	-0.26	medium_impact	-0.18	medium_impact	0.14	0.8	26.05	34.16	0.48	N	0.78	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9751	9751	T	C	MI.7787	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	545	182	F	S	tTc/tCc	4.52	0.99	0	benign	0.13	neutral	0.34	neutral	2.64	neutral	-0.8	deleterious	-2.58	neutral_impact	-0.48	0.74	neutral	0.87	neutral	2.35	18.51	deleterious	0.05	0.35	0.13	neutral	0.32	neutral	0.27	neutral	0.43	neutral	1	0.6	neutral	0.61	deleterious	-6	neutral	0.18	neutral	-0.07	medium_impact	0.03	medium_impact	-1.61	low_impact	0.15	0.8	26.05	34.16	0.52	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9751	9751	T	A	MI.7788	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	545	182	F	Y	tTc/tAc	4.52	0.99	0	benign	0	neutral	1	neutral	2.63	neutral	-0.91	neutral	0.48	neutral_impact	-1.61	0.78	neutral	0.99	neutral	-0.31	0.65	neutral	0.18	0.45	0.12	neutral	0.09	neutral	0.12	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.11	neutral	2.05	high_impact	1.9	high_impact	-2.63	low_impact	0.67	0.85	26.05	34.16	0.5	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9752	9752	C	G	MI.7789	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	546	182	F	L	ttC/ttG	2.9	0.98	0	benign	0.01	neutral	0.56	neutral	2.66	neutral	-0.14	neutral	-0.5	neutral_impact	0.13	0.75	neutral	0.82	neutral	1.21	11.80	neutral	0.16	0.45	0.11	neutral	0.25	neutral	0.18	neutral	0.41	neutral	2	0.42	neutral	0.78	deleterious	-6	neutral	0.11	neutral	1.07	medium_impact	0.25	medium_impact	-1.07	low_impact	0.50	0.8	26.05	34.16	0.51	P	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8893	8893	A	G	MI.779	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	367	123	N	D	Aat/Gat	-1.03	0	0	benign	0.11	neutral	0.59	neutral	3.89	neutral	-0.57	neutral	-0.99	neutral_impact	0.38	0.91	neutral	0.57	neutral	0.35	6.19	deleterious	0.8	0.85	0.28	neutral	0.45	neutral	0.32	neutral	0.47	neutral	1	0.31	neutral	0.74	deleterious	-6	neutral	0.28	neutral	0.11	medium_impact	0.38	medium_impact	-0.77	medium_impact	0.63	0.9	24.34	21.11	0.3	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9752	9752	C	A	MI.7790	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	546	182	F	L	ttC/ttA	2.9	0.98	0	benign	0.01	neutral	0.56	neutral	2.66	neutral	-0.14	neutral	-0.5	neutral_impact	0.13	0.75	neutral	0.82	neutral	1.48	13.22	neutral	0.16	0.45	0.11	neutral	0.25	neutral	0.18	neutral	0.41	neutral	2	0.42	neutral	0.78	deleterious	-6	neutral	0.11	neutral	1.07	medium_impact	0.25	medium_impact	-1.07	low_impact	0.50	0.8	26.05	34.16	0.5	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9753	9753	G	C	MI.7791	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	547	183	E	Q	Gag/Cag	-4.04	0	0	probably_damaging	0.98	neutral	0.29	neutral	2.48	neutral	-1.5	neutral	-2.2	medium_impact	2.37	0.52	damaging	0.55	neutral	3.44	23.00	deleterious	0.31	0.45	0.22	neutral	0.59	disease	0.25	neutral	0.41	neutral	2	0.98	deleterious	0.16	neutral	1	deleterious	0.70	deleterious	-2.51	low_impact	-0.03	medium_impact	0.94	medium_impact	0.54	0.8	73.95	11.58	0.44	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9753	9753	G	A	MI.7792	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	547	183	E	K	Gag/Aag	-4.04	0	0	probably_damaging	0.98	neutral	0.27	neutral	2.47	neutral	-0.98	deleterious	-3.29	medium_impact	2.83	0.56	damaging	0.39	neutral	4.54	24.30	deleterious	0.12	0.4	0.2	neutral	0.83	disease	0.54	disease	0.68	disease	4	0.98	deleterious	0.15	neutral	1	deleterious	0.76	deleterious	-2.51	low_impact	-0.06	medium_impact	1.35	medium_impact	0.77	0.85	73.95	11.58	0.35	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9754	9754	A	C	MI.7793	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	548	183	E	A	gAg/gCg	6.14	1	0	probably_damaging	0.98	neutral	0.5	neutral	2.51	neutral	-1.56	deleterious	-5.03	medium_impact	2.83	0.64	neutral	0.61	neutral	3.88	23.50	deleterious	0.13	0.4	0.25	neutral	0.65	disease	0.5	neutral	0.49	neutral	0	0.98	deleterious	0.26	neutral	1	deleterious	0.71	deleterious	-2.51	low_impact	0.19	medium_impact	1.35	medium_impact	0.26	0.8	73.95	11.58	0.49	N	0.66	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9754	9754	A	T	MI.7794	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	548	183	E	V	gAg/gTg	6.14	1	0	probably_damaging	0.99	neutral	0.48	neutral	2.49	neutral	-2.94	deleterious	-5.91	medium_impact	2.09	0.51	damaging	0.53	neutral	4.43	24.20	deleterious	0.07	0.35	0.36	neutral	0.82	disease	0.43	neutral	0.52	disease	0	0.99	deleterious	0.25	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	0.17	medium_impact	0.69	medium_impact	0.29	0.8	73.95	11.58	0.45	N	0.83	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9754	9754	A	G	MI.7795	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	548	183	E	G	gAg/gGg	6.14	1	0	probably_damaging	0.99	neutral	0.32	neutral	2.47	neutral	-2.12	deleterious	-5.9	medium_impact	2.76	0.54	damaging	0.64	neutral	4.45	24.20	deleterious	0.11	0.4	0.33	neutral	0.74	disease	0.52	disease	0.55	disease	1	0.99	deleterious	0.17	neutral	1	deleterious	0.74	deleterious	-2.81	low_impact	0.01	medium_impact	1.29	medium_impact	0.22	0.8	73.95	11.58	0.46	N	0.62	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9755	9755	G	C	MI.7796	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	549	183	E	D	gaG/gaC	8.69	1	0.03	probably_damaging	0.92	neutral	0.19	neutral	2.47	neutral	-1.77	neutral	-2.34	medium_impact	1.98	0.62	neutral	0.66	neutral	2.72	20.90	deleterious	0.35	0.5	0.29	neutral	0.62	disease	0.24	neutral	0.41	neutral	2	0.95	neutral	0.14	neutral	1	deleterious	0.63	deleterious	-1.9	low_impact	-0.17	medium_impact	0.59	medium_impact	0.63	0.8	73.95	11.58	0.55	P	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9755	9755	G	T	MI.7797	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	549	183	E	D	gaG/gaT	8.69	1	0.03	probably_damaging	0.92	neutral	0.19	neutral	2.47	neutral	-1.77	neutral	-2.34	medium_impact	1.98	0.62	neutral	0.66	neutral	2.87	21.70	deleterious	0.35	0.5	0.29	neutral	0.62	disease	0.24	neutral	0.41	neutral	2	0.95	neutral	0.14	neutral	1	deleterious	0.63	deleterious	-1.9	low_impact	-0.17	medium_impact	0.59	medium_impact	0.63	0.8	73.95	11.58	0.57	P	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9756	9756	T	C	MI.7798	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	550	184	S	P	Tct/Cct	1.75	0.98	0	benign	0.13	neutral	0.23	neutral	2.17	neutral	-2.53	neutral	-2.38	low_impact	1.66	0.44	damaging	0.33	neutral	2.24	17.79	deleterious	0.08	0.35	0.33	neutral	0.87	disease	0.53	disease	0.76	disease	5	0.74	neutral	0.55	deleterious	-6	neutral	0.28	neutral	-0.07	medium_impact	-0.11	medium_impact	0.31	medium_impact	0.12	0.8	14.18	37.72	0.6	P	0.54	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9756	9756	T	A	MI.7799	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	550	184	S	T	Tct/Act	1.75	0.98	0	benign	0.05	neutral	0.44	neutral	2.25	neutral	-0.8	neutral	-0.56	neutral_impact	-0.04	0.75	neutral	0.93	neutral	0.91	10.13	neutral	0.38	0.5	0.12	neutral	0.28	neutral	0.23	neutral	0.4	neutral	2	0.52	neutral	0.7	deleterious	-6	neutral	0.12	neutral	0.37	medium_impact	0.13	medium_impact	-1.22	low_impact	0.48	0.8	14.18	37.72	0.52	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8560	8560	C	G	MI.78	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	34	12	P	A	Ccc/Gcc	0.36	0.11	0	probably_damaging	1	neutral	0.07	neutral	4.67	neutral	0.7	deleterious	-6.91	medium_impact	2.67	0.61	neutral	0.09	damaging	2.85	21.60	deleterious	0.43	0.65	0.49	neutral	0.62	disease	0.58	disease	0.46	neutral	1	1	deleterious	0.04	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	-0.34	medium_impact	1.19	medium_impact	0.80	0.9	50	8.94	0.32	N	0.76	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8893	8893	A	T	MI.780	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	367	123	N	Y	Aat/Tat	-1.03	0	0	possibly_damaging	0.66	neutral	0.14	neutral	4.08	neutral	2.31	neutral	-1.03	low_impact	0.86	0.89	neutral	0.68	neutral	1.13	11.37	neutral	0.49	0.65	0.74	disease	0.57	disease	0.39	neutral	0.43	neutral	1	0.88	neutral	0.24	neutral	-3	neutral	0.63	deleterious	-1.03	low_impact	-0.15	medium_impact	-0.36	medium_impact	0.53	0.9	24.34	21.11	0.42	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9756	9756	T	G	MI.7800	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	550	184	S	A	Tct/Gct	1.75	0.98	0	benign	0	neutral	0.58	neutral	2.63	neutral	1.56	neutral	1.42	neutral_impact	-1.63	0.73	neutral	0.99	neutral	-0.84	0.04	neutral	0.36	0.5	0.13	neutral	0.05	neutral	0.18	neutral	0.25	neutral	5	0.42	neutral	0.79	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	0.27	medium_impact	-2.64	low_impact	0.25	0.8	14.18	37.72	0.49	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9757	9757	C	A	MI.7801	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	551	184	S	Y	tCt/tAt	-0.1	0.93	0	benign	0.37	neutral	1	neutral	2.16	deleterious	-3.37	deleterious	-3.34	medium_impact	2.01	0.54	damaging	0.54	neutral	2.25	17.86	deleterious	0.08	0.35	0.3	neutral	0.73	disease	0.62	disease	0.71	disease	4	0.37	neutral	0.82	deleterious	-3	neutral	0.30	neutral	-0.64	medium_impact	1.9	high_impact	0.62	medium_impact	0.17	0.8	14.18	37.72	0.35	N	0.64	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9757	9757	C	G	MI.7802	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	551	184	S	C	tCt/tGt	-0.1	0.93	0	possibly_damaging	0.44	neutral	0.18	neutral	2.16	deleterious	-3.34	neutral	-1.71	low_impact	0.9	0.5	damaging	0.4	neutral	1.92	15.71	deleterious	0.12	0.4	0.44	neutral	0.71	disease	0.46	neutral	0.54	disease	1	0.79	neutral	0.37	neutral	-3	neutral	0.32	neutral	-0.77	medium_impact	-0.18	medium_impact	-0.38	medium_impact	0.17	0.8	14.18	37.72	0.43	N	0.39	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9757	9757	C	T	MI.7803	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	551	184	S	F	tCt/tTt	-0.1	0.93	0	benign	0.37	neutral	0.72	neutral	2.16	deleterious	-3.24	deleterious	-3.34	low_impact	1.52	0.51	damaging	0.53	neutral	2.51	19.54	deleterious	0.11	0.4	0.18	neutral	0.81	disease	0.62	disease	0.77	disease	5	0.27	neutral	0.68	deleterious	-6	neutral	0.29	neutral	-0.64	medium_impact	0.43	medium_impact	0.18	medium_impact	0.04	0.8	14.18	37.72	0.39	N	0.69	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9759	9759	C	T	MI.7804	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	553	185	P	S	Ccc/Tcc	-8.66	0	0	probably_damaging	0.99	neutral	0.49	neutral	2.61	neutral	0.33	deleterious	-4.54	neutral_impact	0.07	0.7	neutral	0.88	neutral	2.35	18.46	deleterious	0.27	0.45	0.12	neutral	0.31	neutral	0.23	neutral	0.43	neutral	2	0.99	deleterious	0.25	neutral	-2	neutral	0.66	deleterious	-2.81	low_impact	0.18	medium_impact	-1.12	low_impact	0.06	0.8	70.88	9.08	0.3	N	0.23	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9759	9759	C	G	MI.7805	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	553	185	P	A	Ccc/Gcc	-8.66	0	0	probably_damaging	0.97	neutral	0.6	neutral	2.54	neutral	-0.7	deleterious	-5.21	medium_impact	2.08	0.68	neutral	0.55	neutral	1.49	13.26	neutral	0.23	0.45	0.15	neutral	0.43	neutral	0.46	neutral	0.44	neutral	1	0.97	neutral	0.32	neutral	1	deleterious	0.66	deleterious	-2.34	low_impact	0.29	medium_impact	0.68	medium_impact	0.63	0.8	70.88	9.08	0.29	N	0.57	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9759	9759	C	A	MI.7806	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	553	185	P	T	Ccc/Acc	-8.66	0	0	probably_damaging	0.99	neutral	0.4	neutral	2.53	neutral	-0.84	deleterious	-5.05	medium_impact	2	0.64	neutral	0.54	neutral	1.88	15.46	deleterious	0.2	0.45	0.23	neutral	0.58	disease	0.32	neutral	0.44	neutral	1	0.99	deleterious	0.21	neutral	1	deleterious	0.67	deleterious	-2.81	low_impact	0.09	medium_impact	0.61	medium_impact	0.55	0.8	70.88	9.08	0.35	N	0.51	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9760	9760	C	G	MI.7807	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	554	185	P	R	cCc/cGc	0.13	0.01	0	probably_damaging	1	neutral	0.33	neutral	2.51	neutral	-1.3	deleterious	-6.26	medium_impact	3.4	0.67	neutral	0.37	neutral	3.67	23.30	deleterious	0.09	0.35	0.23	neutral	0.82	disease	0.64	disease	0.69	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	0.02	medium_impact	1.86	medium_impact	0.37	0.8	70.88	9.08	0.34	N	0.93	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9760	9760	C	A	MI.7808	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	554	185	P	H	cCc/cAc	0.13	0.01	0	probably_damaging	1	neutral	0.54	neutral	2.51	neutral	-1.36	deleterious	-6.34	medium_impact	2.6	0.67	neutral	0.37	neutral	4.11	23.80	deleterious	0.12	0.4	0.37	neutral	0.72	disease	0.62	disease	0.67	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	0.23	medium_impact	1.15	medium_impact	0.34	0.8	70.88	9.08	0.25	N	0.91	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9760	9760	C	T	MI.7809	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	554	185	P	L	cCc/cTc	0.13	0.01	0	probably_damaging	1	neutral	0.64	neutral	2.52	neutral	-1.2	deleterious	-7.28	medium_impact	2.86	0.67	neutral	0.44	neutral	4.43	24.20	deleterious	0.15	0.4	0.31	neutral	0.79	disease	0.55	disease	0.67	disease	3	1	deleterious	0.32	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	0.33	medium_impact	1.38	medium_impact	0.56	0.8	70.88	9.08	0.29	N	0.84	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8893	8893	A	C	MI.781	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	367	123	N	H	Aat/Cat	-1.03	0	0	possibly_damaging	0.66	neutral	0.33	neutral	3.95	neutral	0.97	neutral	-0.57	neutral_impact	-1.15	0.82	neutral	0.83	neutral	0.59	8.12	deleterious	0.67	0.75	0.36	neutral	0.14	neutral	0.22	neutral	0.29	neutral	4	0.73	neutral	0.34	neutral	-3	neutral	0.52	deleterious	-1.03	low_impact	0.12	medium_impact	-2.08	low_impact	0.51	0.9	24.34	21.11	0.38	N	0.37	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9762	9762	T	C	MI.7810	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	556	186	F	L	Ttc/Ctc	-20	0	0	probably_damaging	0.98	neutral	0.66	neutral	1.81	neutral	-2.74	deleterious	-5.79	medium_impact	2.45	0.64	neutral	0.02	damaging	4.21	23.90	deleterious	0.21	0.45	0.23	neutral	0.69	disease	0.69	disease	0.61	disease	2	0.98	deleterious	0.34	neutral	1	deleterious	0.74	deleterious	-2.51	low_impact	0.36	medium_impact	1.01	medium_impact	0.61	0.8	73.56	11.72	0.21	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9762	9762	T	A	MI.7811	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	556	186	F	I	Ttc/Atc	-20	0	0	probably_damaging	0.99	neutral	0.52	neutral	1.77	deleterious	-3.52	deleterious	-5.79	high_impact	3.86	0.68	neutral	0.02	damaging	4.54	24.30	deleterious	0.14	0.4	0.24	neutral	0.74	disease	0.71	disease	0.71	disease	4	0.99	deleterious	0.27	neutral	2	deleterious	0.75	deleterious	-2.81	low_impact	0.21	medium_impact	2.28	high_impact	0.40	0.8	73.56	11.72	0.26	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9762	9762	T	G	MI.7812	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	556	186	F	V	Ttc/Gtc	-20	0	0	probably_damaging	1	neutral	0.49	neutral	1.77	deleterious	-3.32	deleterious	-6.75	medium_impact	3.22	0.65	neutral	0.01	damaging	4.28	24.00	deleterious	0.06	0.35	0.24	neutral	0.8	disease	0.72	disease	0.71	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.18	medium_impact	1.7	medium_impact	0.25	0.8	73.56	11.72	0.25	N	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9763	9763	T	A	MI.7813	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	557	186	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.98	neutral	1	neutral	1.91	neutral	-1.78	deleterious	-2.89	medium_impact	3.31	0.7	neutral	0.02	damaging	4.36	24.10	deleterious	0.16	0.45	0.3	neutral	0.67	disease	0.64	disease	0.59	disease	2	0.98	deleterious	0.51	deleterious	1	deleterious	0.75	deleterious	-2.51	low_impact	1.9	high_impact	1.78	medium_impact	0.61	0.8	73.56	11.72	0.46	N	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9763	9763	T	C	MI.7814	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	557	186	F	S	tTc/tCc	7.53	1	0	probably_damaging	1	neutral	0.44	neutral	1.77	deleterious	-3.49	deleterious	-7.71	high_impact	4.12	0.54	damaging	0.01	damaging	4.38	24.10	deleterious	0.03	0.35	0.3	neutral	0.8	disease	0.66	disease	0.68	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.13	medium_impact	2.51	high_impact	0.14	0.8	73.56	11.72	0.5	N	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9763	9763	T	G	MI.7815	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	557	186	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	neutral	0.19	neutral	1.71	deleterious	-5.81	deleterious	-7.71	high_impact	4.66	0.73	neutral	0.01	damaging	4.23	23.90	deleterious	0.04	0.35	0.6	disease	0.8	disease	0.73	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.17	medium_impact	2.99	high_impact	0.16	0.8	73.56	11.72	0.57	P	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9764	9764	C	G	MI.7816	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	558	186	F	L	ttC/ttG	7.53	1	0	probably_damaging	0.98	neutral	0.66	neutral	1.81	neutral	-2.74	deleterious	-5.79	medium_impact	2.45	0.64	neutral	0.02	damaging	4.45	24.20	deleterious	0.21	0.45	0.23	neutral	0.69	disease	0.69	disease	0.61	disease	2	0.98	deleterious	0.34	neutral	1	deleterious	0.74	deleterious	-2.51	low_impact	0.36	medium_impact	1.01	medium_impact	0.61	0.8	73.56	11.72	0.4	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9764	9764	C	A	MI.7817	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	558	186	F	L	ttC/ttA	7.53	1	0	probably_damaging	0.98	neutral	0.66	neutral	1.81	neutral	-2.74	deleterious	-5.79	medium_impact	2.45	0.64	neutral	0.02	damaging	4.76	24.70	deleterious	0.21	0.45	0.23	neutral	0.69	disease	0.69	disease	0.61	disease	2	0.98	deleterious	0.34	neutral	1	deleterious	0.74	deleterious	-2.51	low_impact	0.36	medium_impact	1.01	medium_impact	0.61	0.8	73.56	11.72	0.41	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9765	9765	A	G	MI.7818	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	559	187	T	A	Acc/Gcc	-4.73	0	0	benign	0.01	neutral	0.66	neutral	2.39	neutral	-0.99	deleterious	-3.71	low_impact	1.94	0.67	neutral	0.77	neutral	1.64	14.04	neutral	0.18	0.45	0.23	neutral	0.36	neutral	0.49	neutral	0.44	neutral	1	0.33	neutral	0.83	deleterious	-6	neutral	0.13	neutral	1.07	medium_impact	0.36	medium_impact	0.56	medium_impact	0.28	0.8	63.98	10.92	0.37	N	0.43	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9765	9765	A	T	MI.7819	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	559	187	T	S	Acc/Tcc	-4.73	0	0	benign	0.11	neutral	0.59	neutral	2.48	neutral	-0.97	deleterious	-2.64	neutral_impact	0.34	0.65	neutral	0.71	neutral	1.86	15.35	deleterious	0.26	0.45	0.18	neutral	0.19	neutral	0.26	neutral	0.33	neutral	3	0.31	neutral	0.74	deleterious	-6	neutral	0.17	neutral	0.01	medium_impact	0.28	medium_impact	-0.88	medium_impact	0.47	0.8	63.98	10.92	0.33	N	0.07	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8894	8894	A	G	MI.782	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	368	123	N	S	aAt/aGt	-2.42	0	0.02	benign	0.01	neutral	0.81	neutral	3.94	neutral	0.77	neutral	0.54	neutral_impact	-0.28	0.91	neutral	0.97	neutral	-0.80	0.04	neutral	0.83	0.85	0.27	neutral	0.24	neutral	0.18	neutral	0.43	neutral	1	0.16	neutral	0.9	deleterious	-6	neutral	0.12	neutral	1.14	medium_impact	0.65	medium_impact	-1.34	low_impact	0.24	0.9	24.34	21.11	0.34	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9765	9765	A	C	MI.7820	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	559	187	T	P	Acc/Ccc	-4.73	0	0	possibly_damaging	0.64	neutral	0.26	neutral	2.35	neutral	-2.74	deleterious	-4.9	medium_impact	3.15	0.57	damaging	0.41	neutral	3.55	23.10	deleterious	0.04	0.35	0.53	disease	0.79	disease	0.6	disease	0.67	disease	3	0.77	neutral	0.31	neutral	0	NA	0.68	deleterious	-1.11	low_impact	-0.07	medium_impact	1.64	medium_impact	0.29	0.8	63.98	10.92	0.34	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9766	9766	C	G	MI.7821	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	560	187	T	S	aCc/aGc	1.98	0.77	0	benign	0.11	neutral	0.59	neutral	2.48	neutral	-0.97	deleterious	-2.64	neutral_impact	0.34	0.65	neutral	0.71	neutral	2.07	16.65	deleterious	0.26	0.45	0.18	neutral	0.19	neutral	0.26	neutral	0.33	neutral	3	0.31	neutral	0.74	deleterious	-6	neutral	0.17	neutral	0.01	medium_impact	0.28	medium_impact	-0.88	medium_impact	0.47	0.8	63.98	10.92	0.34	N	0.07	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9766	9766	C	A	MI.7822	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	560	187	T	N	aCc/aAc	1.98	0.77	0	possibly_damaging	0.64	neutral	0.41	neutral	2.39	neutral	-1.69	deleterious	-3.62	medium_impact	2.52	0.61	neutral	0.56	neutral	3.74	23.30	deleterious	0.33	0.5	0.39	neutral	0.71	disease	0.36	neutral	0.51	disease	0	0.66	neutral	0.39	neutral	0	NA	0.51	deleterious	-1.11	low_impact	0.1	medium_impact	1.08	medium_impact	0.59	0.8	63.98	10.92	0.36	N	0.52	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9766	9766	C	T	MI.7823	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	560	187	T	I	aCc/aTc	1.98	0.77	0	possibly_damaging	0.59	neutral	0.46	neutral	2.38	deleterious	-3.15	deleterious	-4.98	high_impact	4.05	0.63	neutral	0.56	neutral	4.04	23.70	deleterious	0.13	0.4	0.27	neutral	0.72	disease	0.59	disease	0.66	disease	3	0.59	neutral	0.44	neutral	1	deleterious	0.53	deleterious	-1.02	low_impact	0.15	medium_impact	2.45	high_impact	0.49	0.8	63.98	10.92	0.43	N	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9768	9768	A	C	MI.7824	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	562	188	I	L	Att/Ctt	-5.89	0	0	probably_damaging	0.91	neutral	0.66	neutral	2.14	neutral	-0.71	neutral	-1.7	low_impact	1.34	0.51	damaging	0.13	damaging	3.89	23.50	deleterious	0.22	0.45	0.16	neutral	0.59	disease	0.38	neutral	0.41	neutral	2	0.89	neutral	0.38	neutral	-2	neutral	0.49	deleterious	-1.85	low_impact	0.36	medium_impact	0.02	medium_impact	0.59	0.8	75.48	11.41	0.26	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	COSM1155709	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9768	9768	A	T	MI.7825	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	562	188	I	F	Att/Ttt	-5.89	0	0	probably_damaging	0.98	neutral	0.71	neutral	1.9	neutral	-2.65	deleterious	-3.69	low_impact	1.57	0.53	damaging	0.11	damaging	4.18	23.80	deleterious	0.13	0.4	0.48	neutral	0.63	disease	0.41	neutral	0.45	neutral	1	0.98	deleterious	0.37	neutral	-2	neutral	0.75	deleterious	-2.51	low_impact	0.41	medium_impact	0.22	medium_impact	0.61	0.8	75.48	11.41	0.22	N	0.94	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9768	9768	A	G	MI.7826	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	562	188	I	V	Att/Gtt	-5.89	0	0	possibly_damaging	0.79	neutral	0.51	neutral	2.01	neutral	-1.51	neutral	-0.94	medium_impact	3.19	0.59	damaging	0.18	damaging	3.19	22.70	deleterious	0.37	0.5	0.25	neutral	0.45	neutral	0.58	disease	0.45	neutral	1	0.76	neutral	0.36	neutral	0	NA	0.46	deleterious	-1.43	low_impact	0.2	medium_impact	1.68	medium_impact	0.37	0.8	75.48	11.41	0.34	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9769	9769	T	C	MI.7827	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	563	188	I	T	aTt/aCt	6.84	1	0	probably_damaging	0.99	neutral	0.44	neutral	1.85	deleterious	-3.68	deleterious	-4.66	high_impact	3.88	0.59	damaging	0.01	damaging	3.40	23.00	deleterious	0.04	0.35	0.47	neutral	0.73	disease	0.68	disease	0.67	disease	3	0.99	deleterious	0.23	neutral	2	deleterious	0.78	deleterious	-2.81	low_impact	0.13	medium_impact	2.3	high_impact	0.22	0.8	75.48	11.41	0.48	N	0.91	polymorphism	1	0.15	.	.	.	.	.	.	COSM1138442	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9769	9769	T	A	MI.7828	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	563	188	I	N	aTt/aAt	6.84	1	0	probably_damaging	1	neutral	0.34	neutral	1.82	deleterious	-5.29	deleterious	-6.57	high_impact	3.68	0.63	neutral	0.02	damaging	4.47	24.20	deleterious	0.05	0.35	0.69	disease	0.85	disease	0.69	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	0.03	medium_impact	2.12	high_impact	0.15	0.8	75.48	11.41	0.47	N	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9769	9769	T	G	MI.7829	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	563	188	I	S	aTt/aGt	6.84	1	0	probably_damaging	0.99	neutral	0.46	neutral	1.84	deleterious	-4.28	deleterious	-5.6	high_impact	3.68	0.65	neutral	0.05	damaging	4.36	24.10	deleterious	0.02	0.35	0.54	disease	0.85	disease	0.68	disease	0.73	disease	5	0.99	deleterious	0.24	neutral	2	deleterious	0.83	deleterious	-2.81	low_impact	0.15	medium_impact	2.12	high_impact	0.17	0.8	75.48	11.41	0.47	N	0.93	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8894	8894	A	T	MI.783	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	368	123	N	I	aAt/aTt	-2.42	0	0.02	benign	0.01	neutral	0.24	neutral	3.95	neutral	1.02	neutral	-0.18	neutral_impact	-0.18	0.87	neutral	0.94	neutral	0.05	3.12	deleterious	0.48	0.65	0.64	disease	0.43	neutral	0.21	neutral	0.59	disease	2	0.76	neutral	0.62	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	0.01	medium_impact	-1.25	low_impact	0.35	0.9	24.34	21.11	0.39	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9770	9770	T	G	MI.7830	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	564	188	I	M	atT/atG	5.68	1	0.01	probably_damaging	0.99	neutral	0.23	neutral	1.89	neutral	-2.75	deleterious	-2.61	low_impact	1.47	0.54	damaging	0.09	damaging	3.54	23.10	deleterious	0.21	0.45	0.26	neutral	0.43	neutral	0.36	neutral	0.4	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.68	deleterious	-2.81	low_impact	-0.11	medium_impact	0.14	medium_impact	0.49	0.8	75.48	11.41	0.49	N	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9770	9770	T	A	MI.7831	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	564	188	I	M	atT/atA	5.68	1	0.01	probably_damaging	0.99	neutral	0.23	neutral	1.89	neutral	-2.75	deleterious	-2.61	low_impact	1.47	0.54	damaging	0.09	damaging	3.75	23.30	deleterious	0.21	0.45	0.26	neutral	0.43	neutral	0.36	neutral	0.4	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.68	deleterious	-2.81	low_impact	-0.11	medium_impact	0.14	medium_impact	0.49	0.8	75.48	11.41	0.49	P	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9771	9771	T	C	MI.7832	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	565	189	S	P	Tcc/Ccc	-4.04	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.97	deleterious	-3.7	deleterious	-3.22	medium_impact	2.04	0.48	damaging	0.05	damaging	4.07	23.70	deleterious	0.05	0.35	0.47	neutral	0.86	disease	0.69	disease	0.69	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.80	deleterious	-2.81	low_impact	-0.15	medium_impact	0.65	medium_impact	0.09	0.8	74.33	11.3	0.27	N	0.98	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9771	9771	T	A	MI.7833	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	565	189	S	T	Tcc/Acc	-4.04	0	0	probably_damaging	0.92	neutral	0.4	neutral	2.03	neutral	-2.24	neutral	-1.74	low_impact	1.1	0.62	neutral	0.14	damaging	3.86	23.50	deleterious	0.25	0.45	0.22	neutral	0.52	disease	0.38	neutral	0.45	neutral	1	0.92	neutral	0.24	neutral	-2	neutral	0.55	deleterious	-1.9	low_impact	0.09	medium_impact	-0.2	medium_impact	0.50	0.8	74.33	11.3	0.28	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9771	9771	T	G	MI.7834	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	565	189	S	A	Tcc/Gcc	-4.04	0	0	probably_damaging	0.96	neutral	0.53	neutral	2.25	neutral	-0.33	neutral	0.22	neutral_impact	-0.08	0.7	neutral	0.78	neutral	1.08	11.11	neutral	0.28	0.45	0.19	neutral	0.09	neutral	0.28	neutral	0.23	neutral	5	0.95	neutral	0.29	neutral	-2	neutral	0.44	deleterious	-2.21	low_impact	0.22	medium_impact	-1.25	low_impact	0.24	0.8	74.33	11.3	0.36	N	0.40	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9772	9772	C	A	MI.7835	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	566	189	S	Y	tCc/tAc	1.05	0.87	0	probably_damaging	1	neutral	1	neutral	1.95	deleterious	-4.6	deleterious	-4.19	medium_impact	3.16	0.55	damaging	0.06	damaging	4.15	23.80	deleterious	0.06	0.35	0.54	disease	0.83	disease	0.71	disease	0.76	disease	5	1	deleterious	0.5	deleterious	1	deleterious	0.79	deleterious	-3.78	low_impact	1.9	high_impact	1.65	medium_impact	0.14	0.8	74.33	11.3	0.27	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9772	9772	C	G	MI.7836	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	566	189	S	C	tCc/tGc	1.05	0.87	0	probably_damaging	1	neutral	0.17	neutral	1.95	deleterious	-4.53	deleterious	-2.71	medium_impact	3.16	0.57	damaging	0.06	damaging	3.69	23.30	deleterious	0.06	0.35	0.72	disease	0.83	disease	0.58	disease	0.72	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	-0.2	medium_impact	1.65	medium_impact	0.20	0.8	74.33	11.3	0.27	N	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9772	9772	C	T	MI.7837	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	566	189	S	F	tCc/tTc	1.05	0.87	0	probably_damaging	1	neutral	0.71	neutral	1.95	deleterious	-4.5	deleterious	-4.19	medium_impact	3.16	0.52	damaging	0.06	damaging	4.37	24.10	deleterious	0.07	0.35	0.59	disease	0.86	disease	0.71	disease	0.77	disease	5	1	deleterious	0.36	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	0.41	medium_impact	1.65	medium_impact	0.04	0.8	74.33	11.3	0.28	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9774	9774	G	T	MI.7838	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	568	190	D	Y	Gac/Tac	-13.98	0	0	probably_damaging	1	neutral	0.44	neutral	1.26	deleterious	-6.83	deleterious	-8.63	high_impact	4.51	0.62	neutral	0.01	damaging	4.01	23.60	deleterious	0.03	0.35	0.61	disease	0.94	disease	0.78	disease	0.87	disease	7	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	0.13	medium_impact	2.86	high_impact	0.04	0.8	73.95	11.69	0.43	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9774	9774	G	C	MI.7839	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	568	190	D	H	Gac/Cac	-13.98	0	0	probably_damaging	1	neutral	0.28	neutral	1.27	deleterious	-6.1	deleterious	-6.7	high_impact	3.62	0.57	damaging	0.01	damaging	3.77	23.40	deleterious	0.08	0.35	0.51	disease	0.88	disease	0.78	disease	0.77	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.04	medium_impact	2.06	high_impact	0.28	0.8	73.95	11.69	0.33	N	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8894	8894	A	C	MI.784	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	368	123	N	T	aAt/aCt	-2.42	0	0.02	benign	0.11	neutral	0.59	neutral	3.93	neutral	0.59	neutral	0.39	neutral_impact	0.07	0.87	neutral	0.97	neutral	-0.39	0.41	neutral	0.64	0.7	0.43	neutral	0.25	neutral	0.17	neutral	0.45	neutral	1	0.31	neutral	0.74	deleterious	-6	neutral	0.22	neutral	0.11	medium_impact	0.38	medium_impact	-1.04	low_impact	0.50	0.9	24.34	21.11	0.37	N	0.16	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9774	9774	G	A	MI.7840	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	568	190	D	N	Gac/Aac	-13.98	0	0	probably_damaging	1	neutral	0.54	neutral	1.32	deleterious	-4.5	deleterious	-4.79	medium_impact	3.27	0.53	damaging	0.03	damaging	4.32	24.00	deleterious	0.53	0.6	0.34	neutral	0.85	disease	0.64	disease	0.65	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	0.23	medium_impact	1.75	medium_impact	0.69	0.85	73.95	11.69	0.25	N	0.96	polymorphism	1	0.11	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9775	9775	A	C	MI.7841	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	569	190	D	A	gAc/gCc	9.15	1	0	probably_damaging	1	neutral	0.91	neutral	1.31	deleterious	-4.76	deleterious	-7.67	medium_impact	2.94	0.59	damaging	0.02	damaging	3.86	23.50	deleterious	0.08	0.35	0.25	neutral	0.85	disease	0.74	disease	0.73	disease	5	1	deleterious	0.46	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.76	medium_impact	1.45	medium_impact	0.15	0.8	73.95	11.69	0.39	N	0.83	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9775	9775	A	G	MI.7842	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	569	190	D	G	gAc/gGc	9.15	1	0	probably_damaging	1	neutral	0.45	neutral	1.3	deleterious	-4.99	deleterious	-6.72	medium_impact	2.63	0.6	damaging	0.01	damaging	4.21	23.90	deleterious	0.08	0.35	0.44	neutral	0.83	disease	0.7	disease	0.55	disease	1	1	deleterious	0.23	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	0.14	medium_impact	1.17	medium_impact	0.12	0.8	73.95	11.69	0.41	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9775	9775	A	T	MI.7843	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	569	190	D	V	gAc/gTc	9.15	1	0	probably_damaging	1	neutral	0.46	neutral	1.27	deleterious	-5.97	deleterious	-8.63	high_impact	3.7	0.56	damaging	0.01	damaging	4.00	23.60	deleterious	0.03	0.35	0.45	neutral	0.94	disease	0.75	disease	0.85	disease	7	1	deleterious	0.23	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.15	medium_impact	2.13	high_impact	0.03	0.8	73.95	11.69	0.48	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9776	9776	C	G	MI.7844	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	570	190	D	E	gaC/gaG	8.69	1	0	probably_damaging	0.99	neutral	1	neutral	1.37	deleterious	-3.63	deleterious	-3.8	medium_impact	3.04	0.6	damaging	0.03	damaging	3.95	23.60	deleterious	0.25	0.45	0.23	neutral	0.79	disease	0.61	disease	0.51	disease	0	0.99	deleterious	0.51	deleterious	1	deleterious	0.76	deleterious	-2.81	low_impact	1.9	high_impact	1.54	medium_impact	0.38	0.8	73.95	11.69	0.41	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9776	9776	C	A	MI.7845	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	570	190	D	E	gaC/gaA	8.69	1	0	probably_damaging	0.99	neutral	1	neutral	1.37	deleterious	-3.63	deleterious	-3.8	medium_impact	3.04	0.6	damaging	0.03	damaging	4.29	24.00	deleterious	0.25	0.45	0.23	neutral	0.79	disease	0.61	disease	0.51	disease	0	0.99	deleterious	0.51	deleterious	1	deleterious	0.76	deleterious	-2.81	low_impact	1.9	high_impact	1.54	medium_impact	0.38	0.8	73.95	11.69	0.41	N	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9777	9777	G	A	MI.7846	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	571	191	G	S	Ggc/Agc	-6.58	0	0	probably_damaging	1	neutral	0.43	neutral	2.7	neutral	0.59	neutral	1.27	neutral_impact	-0.25	0.62	neutral	0.66	neutral	1.91	15.67	deleterious	0.14	0.4	0.1	neutral	0.11	neutral	0.25	neutral	0.25	neutral	5	1	deleterious	0.22	neutral	-2	neutral	0.66	deleterious	-3.78	low_impact	0.12	medium_impact	-1.41	low_impact	0.52	0.8	73.95	11.23	0.38	N	0.85	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9777	9777	G	T	MI.7847	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	571	191	G	C	Ggc/Tgc	-6.58	0	0	probably_damaging	1	neutral	0.17	neutral	2.34	deleterious	-4.81	neutral	-2.06	high_impact	3.9	0.62	neutral	0.19	damaging	4.21	23.90	deleterious	0.04	0.35	0.65	disease	0.87	disease	0.6	disease	0.76	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.2	medium_impact	2.31	high_impact	0.21	0.8	73.95	11.23	0.32	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9777	9777	G	C	MI.7848	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	571	191	G	R	Ggc/Cgc	-6.58	0	0	probably_damaging	1	neutral	0.33	neutral	2.39	neutral	-2.28	neutral	-2.27	high_impact	3.55	0.58	damaging	0.19	damaging	4.10	23.70	deleterious	0.03	0.35	0.27	neutral	0.86	disease	0.81	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.02	medium_impact	2	medium_impact	0.44	0.8	73.95	11.23	0.38	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9778	9778	G	C	MI.7849	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	572	191	G	A	gGc/gCc	1.98	0.98	0	probably_damaging	1	neutral	0.54	neutral	2.4	neutral	-1.86	neutral	-0.12	medium_impact	2.45	0.66	neutral	0.7	neutral	1.74	14.65	neutral	0.13	0.4	0.14	neutral	0.45	neutral	0.37	neutral	0.44	neutral	1	1	deleterious	0.27	neutral	1	deleterious	0.69	deleterious	-3.78	low_impact	0.23	medium_impact	1.01	medium_impact	0.46	0.8	73.95	11.23	0.49	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8895	8895	T	G	MI.785	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	369	123	N	K	aaT/aaG	-3.34	0	0	benign	0.16	neutral	1	neutral	3.93	neutral	0.61	neutral	-0.31	neutral_impact	-0.62	0.94	neutral	0.79	neutral	0.53	7.62	deleterious	0.79	0.85	0.3	neutral	0.51	disease	0.19	neutral	0.34	neutral	3	0.16	neutral	0.92	deleterious	-6	neutral	0.30	neutral	-0.07	medium_impact	1.98	high_impact	-1.63	low_impact	0.59	0.9	24.34	21.11	0.31	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9778	9778	G	T	MI.7850	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	572	191	G	V	gGc/gTc	1.98	0.98	0	probably_damaging	1	neutral	0.52	neutral	2.34	deleterious	-4.57	deleterious	-2.94	high_impact	3.55	0.59	damaging	0.25	damaging	3.90	23.50	deleterious	0.03	0.35	0.32	neutral	0.79	disease	0.71	disease	0.76	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	0.21	medium_impact	2	medium_impact	0.13	0.8	73.95	11.23	0.42	N	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9778	9778	G	A	MI.7851	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	572	191	G	D	gGc/gAc	1.98	0.98	0	probably_damaging	1	neutral	0.28	neutral	2.44	neutral	-1.23	neutral	-1.6	medium_impact	2.75	0.6	neutral	0.23	damaging	3.91	23.50	deleterious	0.04	0.35	0.22	neutral	0.81	disease	0.78	disease	0.71	disease	4	1	deleterious	0.14	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	-0.04	medium_impact	1.28	medium_impact	0.14	0.8	73.95	11.23	0.48	P	0.98	polymorphism	1	0.03	.	.	.	.	.	.	COSM6716204	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9780	9780	A	G	MI.7852	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	574	192	I	V	Atc/Gtc	-12.13	0	0	possibly_damaging	0.9	neutral	0.52	neutral	2.57	neutral	0.88	neutral	0.47	neutral_impact	-0.78	0.74	neutral	0.98	neutral	-1.40	0.00	neutral	0.6	0.65	0.11	neutral	0.05	neutral	0.23	neutral	0.23	neutral	5	0.89	neutral	0.31	neutral	-3	neutral	0.50	deleterious	-1.8	low_impact	0.21	medium_impact	-1.88	low_impact	0.40	0.8	14.56	21.19	0.4	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9780	9780	A	C	MI.7853	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	574	192	I	L	Atc/Ctc	-12.13	0	0	possibly_damaging	0.9	neutral	0.62	neutral	2.12	neutral	-1.27	neutral	-1.34	low_impact	1.38	0.64	neutral	0.1	damaging	2.21	17.58	deleterious	0.2	0.45	0.16	neutral	0.56	disease	0.62	disease	0.62	disease	2	0.88	neutral	0.36	neutral	-3	neutral	0.56	deleterious	-1.8	low_impact	0.31	medium_impact	0.05	medium_impact	0.73	0.85	14.56	21.19	0.2	N	0.47	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9780	9780	A	T	MI.7854	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	574	192	I	F	Atc/Ttc	-12.13	0	0	probably_damaging	0.98	neutral	0.68	neutral	2	deleterious	-3.41	deleterious	-2.96	medium_impact	3.4	0.6	damaging	0.11	damaging	3.88	23.50	deleterious	0.11	0.4	0.34	neutral	0.78	disease	0.68	disease	0.73	disease	5	0.98	neutral	0.35	neutral	1	deleterious	0.72	deleterious	-2.51	low_impact	0.38	medium_impact	1.86	medium_impact	0.64	0.8	14.56	21.19	0.22	N	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9781	9781	T	C	MI.7855	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	575	192	I	T	aTc/aCc	-0.1	0.01	0	probably_damaging	0.98	neutral	0.39	neutral	2.02	neutral	-2.86	neutral	-1.89	low_impact	1.56	0.64	neutral	0.37	neutral	2.08	16.74	deleterious	0.06	0.35	0.28	neutral	0.57	disease	0.57	disease	0.5	neutral	0	0.98	deleterious	0.21	neutral	-2	neutral	0.69	deleterious	-2.51	low_impact	0.08	medium_impact	0.22	medium_impact	0.26	0.8	14.56	21.19	0.33	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9781	9781	T	A	MI.7856	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	575	192	I	N	aTc/aAc	-0.1	0.01	0	probably_damaging	1	neutral	0.3	neutral	1.98	deleterious	-4.47	deleterious	-4.41	medium_impact	2.51	0.62	neutral	0.1	damaging	4.50	24.30	deleterious	0.06	0.35	0.49	neutral	0.84	disease	0.68	disease	0.76	disease	5	1	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	-0.02	medium_impact	1.07	medium_impact	0.22	0.8	14.56	21.19	0.24	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9781	9781	T	G	MI.7857	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	575	192	I	S	aTc/aGc	-0.1	0.01	0	probably_damaging	0.98	neutral	0.45	neutral	2	deleterious	-3.42	deleterious	-3	low_impact	1.47	0.63	neutral	0.27	damaging	4.31	24.00	deleterious	0.02	0.35	0.33	neutral	0.78	disease	0.58	disease	0.55	disease	1	0.98	deleterious	0.24	neutral	-2	neutral	0.73	deleterious	-2.51	low_impact	0.14	medium_impact	0.14	medium_impact	0.20	0.8	14.56	21.19	0.25	N	0.91	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9782	9782	C	A	MI.7858	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	576	192	I	M	atC/atA	4.52	0.69	0	probably_damaging	0.99	neutral	0.21	neutral	2.01	deleterious	-3.15	neutral	-1.56	medium_impact	2.86	0.63	neutral	0.1	damaging	3.89	23.50	deleterious	0.21	0.45	0.21	neutral	0.51	disease	0.67	disease	0.68	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.66	deleterious	-2.81	low_impact	-0.14	medium_impact	1.38	medium_impact	0.73	0.85	14.56	21.19	0.34	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9782	9782	C	G	MI.7859	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	576	192	I	M	atC/atG	4.52	0.69	0	probably_damaging	0.99	neutral	0.21	neutral	2.01	deleterious	-3.15	neutral	-1.56	medium_impact	2.86	0.63	neutral	0.1	damaging	3.45	23.00	deleterious	0.21	0.45	0.21	neutral	0.51	disease	0.67	disease	0.68	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.66	deleterious	-2.81	low_impact	-0.14	medium_impact	1.38	medium_impact	0.73	0.85	14.56	21.19	0.38	N	0.61	polymorphism	1	0.03	rs28433045	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8895	8895	T	A	MI.786	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	369	123	N	K	aaT/aaA	-3.34	0	0	benign	0.16	neutral	1	neutral	3.93	neutral	0.61	neutral	-0.31	neutral_impact	-0.62	0.94	neutral	0.79	neutral	0.82	9.58	deleterious	0.79	0.85	0.3	neutral	0.51	disease	0.19	neutral	0.34	neutral	3	0.16	neutral	0.92	deleterious	-6	neutral	0.30	neutral	-0.07	medium_impact	1.98	high_impact	-1.63	low_impact	0.59	0.9	24.34	21.11	0.31	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9783	9783	T	G	MI.7860	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	577	193	Y	D	Tac/Gac	-14.68	0	0	probably_damaging	1	neutral	0.2	neutral	1.57	deleterious	-6.21	deleterious	-9.45	high_impact	4.61	0.61	neutral	0.01	damaging	4.04	23.70	deleterious	0.02	0.35	0.79	disease	0.86	disease	0.84	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.15	medium_impact	2.95	high_impact	0.13	0.8	74.33	11.58	0.48	N	0.99	disease_causing	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9783	9783	T	C	MI.7861	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	577	193	Y	H	Tac/Cac	-14.68	0	0	probably_damaging	1	neutral	0.52	neutral	1.6	deleterious	-4.51	deleterious	-4.75	high_impact	3.92	0.57	damaging	0.03	damaging	3.68	23.30	deleterious	0.1	0.4	0.62	disease	0.79	disease	0.84	disease	0.8	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	0.21	medium_impact	2.33	high_impact	0.22	0.8	74.33	11.58	0.3	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9783	9783	T	A	MI.7862	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	577	193	Y	N	Tac/Aac	-14.68	0	0	probably_damaging	1	neutral	0.29	neutral	1.58	deleterious	-5.41	deleterious	-8.52	high_impact	4.26	0.59	damaging	0.01	damaging	4.11	23.70	deleterious	0.03	0.35	0.7	disease	0.85	disease	0.78	disease	0.78	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.03	medium_impact	2.64	high_impact	0.11	0.8	74.33	11.58	0.39	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9784	9784	A	G	MI.7863	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	578	193	Y	C	tAc/tGc	7.53	1	0	probably_damaging	1	neutral	0.18	neutral	1.56	deleterious	-6.64	deleterious	-8.49	high_impact	3.8	0.63	neutral	0.02	damaging	3.66	23.20	deleterious	0.03	0.35	0.79	disease	0.89	disease	0.8	disease	0.83	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.18	medium_impact	2.22	high_impact	0.13	0.8	74.33	11.58	0.52	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9784	9784	A	C	MI.7864	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	578	193	Y	S	tAc/tCc	7.53	1	0	probably_damaging	1	neutral	0.42	neutral	1.59	deleterious	-4.98	deleterious	-8.49	high_impact	4.61	0.61	neutral	0.02	damaging	3.84	23.40	deleterious	0.04	0.35	0.59	disease	0.85	disease	0.77	disease	0.78	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	0.11	medium_impact	2.95	high_impact	0.15	0.8	74.33	11.58	0.57	P	0.96	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9784	9784	A	T	MI.7865	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	578	193	Y	F	tAc/tTc	7.53	1	0	probably_damaging	0.99	neutral	0.68	neutral	1.89	neutral	-1.42	deleterious	-3.62	low_impact	1.69	0.56	damaging	0.08	damaging	3.53	23.10	deleterious	0.24	0.45	0.16	neutral	0.64	disease	0.54	disease	0.42	neutral	2	0.99	deleterious	0.35	neutral	-2	neutral	0.74	deleterious	-2.81	low_impact	0.38	medium_impact	0.33	medium_impact	0.50	0.8	74.33	11.58	0.44	N	0.72	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9786	9786	G	T	MI.7866	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	580	194	G	C	Ggc/Tgc	-6.81	0	0	probably_damaging	1	neutral	0.17	neutral	0.89	deleterious	-7.58	deleterious	-8.61	high_impact	4.72	0.55	damaging	0.01	damaging	4.27	24.00	deleterious	0.03	0.35	0.77	disease	0.92	disease	0.75	disease	0.8	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.2	medium_impact	3.05	high_impact	0.28	0.8	73.18	11.8	0.5	N	0.98	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9786	9786	G	C	MI.7867	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	580	194	G	R	Ggc/Cgc	-6.81	0	0	probably_damaging	1	neutral	0.33	neutral	0.9	deleterious	-6.58	deleterious	-7.65	high_impact	4.72	0.62	neutral	0.02	damaging	4.12	23.80	deleterious	0.03	0.35	0.6	disease	0.91	disease	0.84	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	0.02	medium_impact	3.05	high_impact	0.51	0.8	73.18	11.8	0.55	P	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9786	9786	G	A	MI.7868	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	580	194	G	S	Ggc/Agc	-6.81	0	0	probably_damaging	1	neutral	0.43	neutral	0.94	deleterious	-5.26	deleterious	-5.74	medium_impact	3.08	0.55	damaging	0.03	damaging	4.38	24.10	deleterious	0.06	0.35	0.5	neutral	0.81	disease	0.65	disease	0.52	disease	0	1	deleterious	0.22	neutral	1	deleterious	0.84	deleterious	-3.78	low_impact	0.12	medium_impact	1.58	medium_impact	0.58	0.8	73.18	11.8	0.18	N	0.85	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9787	9787	G	C	MI.7869	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	581	194	G	A	gGc/gCc	7.3	1	0	probably_damaging	1	neutral	0.48	neutral	0.95	deleterious	-4.99	deleterious	-5.74	medium_impact	2.89	0.55	damaging	0.02	damaging	3.25	22.80	deleterious	0.08	0.35	0.44	neutral	0.69	disease	0.72	disease	0.68	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.79	deleterious	-3.78	low_impact	0.17	medium_impact	1.41	medium_impact	0.52	0.8	73.18	11.8	0.43	N	0.30	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8896	8896	G	A	MI.787	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	370	124	A	T	Gcc/Acc	-6.12	0	0	benign	0	neutral	0.39	neutral	3.89	neutral	-1	neutral	-0.66	low_impact	1.29	0.91	neutral	0.77	neutral	1.16	11.55	neutral	0.48	0.65	0.55	disease	0.55	disease	0.25	neutral	0.28	neutral	4	0.61	neutral	0.7	deleterious	-6	neutral	0.20	neutral	2.09	high_impact	0.18	medium_impact	0.01	medium_impact	0.80	0.9	19.91	7.92	0.36	N	0.06	polymorphism	1	0.01	rs202120082	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9787	9787	G	T	MI.7870	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	581	194	G	V	gGc/gTc	7.3	1	0	probably_damaging	1	neutral	0.5	neutral	0.9	deleterious	-6.37	deleterious	-8.61	high_impact	4.72	0.52	damaging	0.01	damaging	3.90	23.50	deleterious	0.03	0.35	0.42	neutral	0.9	disease	0.77	disease	0.78	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	0.19	medium_impact	3.05	high_impact	0.16	0.8	73.18	11.8	0.54	P	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9787	9787	G	A	MI.7871	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	581	194	G	D	gGc/gAc	7.3	1	0	probably_damaging	1	neutral	0.2	neutral	0.91	deleterious	-6.07	deleterious	-6.7	high_impact	4.17	0.48	damaging	0.01	damaging	3.92	23.50	deleterious	0.03	0.35	0.68	disease	0.88	disease	0.83	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.15	medium_impact	2.55	high_impact	0.23	0.8	73.18	11.8	0.6	P	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9789	9789	T	C	MI.7872	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	583	195	S	P	Tca/Cca	-3.11	0	0	probably_damaging	0.99	neutral	0.17	neutral	1.76	deleterious	-4.41	deleterious	-4.58	high_impact	4.12	0.49	damaging	0.04	damaging	4.12	23.80	deleterious	0.02	0.35	0.68	disease	0.87	disease	0.81	disease	0.81	disease	6	0.99	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-2.81	low_impact	-0.2	medium_impact	2.51	high_impact	0.35	0.8	73.56	11.73	0.5	N	0.98	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	T9789C	Myopathy	-	+	Reported	1	.	P	P	damaging
chrM	9789	9789	T	A	MI.7873	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	583	195	S	T	Tca/Aca	-3.11	0	0	probably_damaging	0.92	neutral	0.58	neutral	1.86	neutral	-2.35	neutral	-2.48	low_impact	1.56	0.58	damaging	0.26	damaging	2.80	21.30	deleterious	0.13	0.4	0.23	neutral	0.56	disease	0.44	neutral	0.42	neutral	2	0.91	neutral	0.33	neutral	-2	neutral	0.66	deleterious	-1.9	low_impact	0.27	medium_impact	0.22	medium_impact	0.73	0.85	73.56	11.73	0.24	N	0.63	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9789	9789	T	G	MI.7874	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	583	195	S	A	Tca/Gca	-3.11	0	0	probably_damaging	0.96	neutral	0.43	neutral	1.91	neutral	-1.88	deleterious	-2.69	low_impact	1.94	0.59	damaging	0.34	neutral	2.78	21.30	deleterious	0.11	0.4	0.31	neutral	0.44	neutral	0.47	neutral	0.4	neutral	2	0.95	neutral	0.24	neutral	-2	neutral	0.60	deleterious	-2.21	low_impact	0.12	medium_impact	0.56	medium_impact	0.48	0.8	73.56	11.73	0.3	N	0.40	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9790	9790	C	T	MI.7875	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	584	195	S	L	tCa/tTa	5.68	1	0	probably_damaging	0.99	neutral	0.57	neutral	1.77	deleterious	-3.95	deleterious	-5.47	high_impact	4.46	0.49	damaging	0.03	damaging	4.76	24.70	deleterious	0.02	0.35	0.67	disease	0.89	disease	0.68	disease	0.74	disease	5	0.99	deleterious	0.29	neutral	2	deleterious	0.83	deleterious	-2.81	low_impact	0.26	medium_impact	2.81	high_impact	0.39	0.8	73.56	11.73	0.57	P	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9790	9790	C	G	MI.7876	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	584	195	S	W	tCa/tGa	5.68	1	0	probably_damaging	1	neutral	0.2	neutral	1.73	deleterious	-7.26	deleterious	-6.44	high_impact	4.46	0.53	damaging	0.03	damaging	4.46	24.20	deleterious	0.03	0.35	0.94	disease	0.91	disease	0.76	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.15	medium_impact	2.81	high_impact	0.15	0.8	73.56	11.73	0.54	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9792	9792	A	G	MI.7877	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	586	196	T	A	Aca/Gca	-6.35	0	0	probably_damaging	0.98	neutral	0.54	neutral	2.23	neutral	-0.68	deleterious	-3.86	medium_impact	2.14	0.68	neutral	0.67	neutral	3.59	23.20	deleterious	0.16	0.45	0.16	neutral	0.6	disease	0.44	neutral	0.43	neutral	1	0.97	neutral	0.28	neutral	1	deleterious	0.67	deleterious	-2.51	low_impact	0.23	medium_impact	0.74	medium_impact	0.37	0.8	74.71	11.64	0.29	N	0.44	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9792	9792	A	C	MI.7878	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	586	196	T	P	Aca/Cca	-6.35	0	0	probably_damaging	1	neutral	0.18	neutral	2.14	deleterious	-3.99	deleterious	-5	high_impact	4.17	0.63	neutral	0.44	neutral	3.61	23.20	deleterious	0.03	0.35	0.5	disease	0.87	disease	0.77	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.18	medium_impact	2.55	high_impact	0.31	0.8	74.71	11.64	0.47	N	0.98	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9792	9792	A	T	MI.7879	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	586	196	T	S	Aca/Tca	-6.35	0	0	probably_damaging	0.98	neutral	0.66	neutral	2.21	neutral	-1.44	deleterious	-3.08	low_impact	1.59	0.59	damaging	0.71	neutral	2.41	18.90	deleterious	0.23	0.45	0.24	neutral	0.56	disease	0.39	neutral	0.44	neutral	1	0.97	neutral	0.34	neutral	-2	neutral	0.70	deleterious	-2.51	low_impact	0.36	medium_impact	0.24	medium_impact	0.58	0.8	74.71	11.64	0.31	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8896	8896	G	C	MI.788	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	370	124	A	P	Gcc/Ccc	-6.12	0	0	benign	0.27	neutral	0.18	neutral	3.84	neutral	-2.18	deleterious	-2.57	medium_impact	3.21	0.69	neutral	0.39	neutral	2.16	17.26	deleterious	0.14	0.65	0.79	disease	0.91	disease	0.73	disease	0.75	disease	5	0.79	neutral	0.46	neutral	-3	neutral	0.57	deleterious	-0.35	medium_impact	-0.08	medium_impact	1.65	medium_impact	0.81	0.9	19.91	7.92	0.32	N	0.46	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9793	9793	C	T	MI.7880	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	587	196	T	M	aCa/aTa	6.84	1	0	probably_damaging	1	neutral	0.23	neutral	2.17	neutral	-2.34	deleterious	-4.57	medium_impact	2.67	0.66	neutral	0.55	neutral	4.10	23.70	deleterious	0.05	0.35	0.32	neutral	0.76	disease	0.67	disease	0.68	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.70	deleterious	-3.78	low_impact	-0.11	medium_impact	1.21	medium_impact	0.60	0.8	74.71	11.64	0.49	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9793	9793	C	A	MI.7881	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	587	196	T	K	aCa/aAa	6.84	1	0	probably_damaging	1	neutral	0.26	neutral	2.17	deleterious	-3.09	deleterious	-4.91	high_impact	4.17	0.65	neutral	0.41	neutral	4.70	24.60	deleterious	0.04	0.35	0.35	neutral	0.88	disease	0.75	disease	0.77	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.07	medium_impact	2.55	high_impact	0.49	0.8	74.71	11.64	0.62	P	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9795	9795	T	C	MI.7882	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	589	197	F	L	Ttt/Ctt	-5.66	0	0	probably_damaging	0.98	neutral	0.39	neutral	1.55	deleterious	-4	deleterious	-5.71	high_impact	4.44	0.64	neutral	0.03	damaging	4.13	23.80	deleterious	0.04	0.35	0.59	disease	0.83	disease	0.74	disease	0.76	disease	5	0.99	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-2.51	low_impact	0.08	medium_impact	2.8	high_impact	0.56	0.8	72.41	11.91	0.41	N	0.92	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9795	9795	T	G	MI.7883	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	589	197	F	V	Ttt/Gtt	-5.66	0	0	probably_damaging	1	neutral	0.23	neutral	1.49	deleterious	-5.23	deleterious	-6.67	high_impact	4.79	0.65	neutral	0.02	damaging	4.16	23.80	deleterious	0.04	0.35	0.75	disease	0.9	disease	0.77	disease	0.79	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.11	medium_impact	3.11	high_impact	0.33	0.8	72.41	11.91	0.62	P	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9795	9795	T	A	MI.7884	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	589	197	F	I	Ttt/Att	-5.66	0	0	probably_damaging	0.99	neutral	0.19	neutral	1.47	deleterious	-6.04	deleterious	-5.71	high_impact	4.79	0.68	neutral	0.03	damaging	4.49	24.30	deleterious	0.05	0.35	0.75	disease	0.86	disease	0.76	disease	0.78	disease	6	0.99	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.17	medium_impact	3.11	high_impact	0.44	0.8	72.41	11.91	0.63	P	0.96	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9796	9796	T	G	MI.7885	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	590	197	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	neutral	0.06	neutral	1.48	deleterious	-5.71	deleterious	-7.62	high_impact	4.79	0.71	neutral	0.02	damaging	4.21	23.90	deleterious	0.02	0.35	0.92	disease	0.9	disease	0.79	disease	0.86	disease	7	1	deleterious	0.03	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.49	medium_impact	3.11	high_impact	0.20	0.8	72.41	11.91	0.65	P	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9796	9796	T	C	MI.7886	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	590	197	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	neutral	0.33	neutral	1.47	deleterious	-5.88	deleterious	-7.62	high_impact	4.44	0.71	neutral	0.02	damaging	4.41	24.10	deleterious	0.02	0.35	0.82	disease	0.88	disease	0.75	disease	0.8	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.78	low_impact	0.02	medium_impact	2.8	high_impact	0.23	0.8	72.41	11.91	0.58	P	0.96	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9796	9796	T	A	MI.7887	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	590	197	F	Y	tTt/tAt	7.53	1	0	probably_damaging	0.98	neutral	0.38	neutral	1.75	neutral	-2.38	deleterious	-2.86	high_impact	3.58	0.7	neutral	0.03	damaging	4.57	24.40	deleterious	0.09	0.35	0.31	neutral	0.84	disease	0.73	disease	0.75	disease	5	0.99	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-2.51	low_impact	0.07	medium_impact	2.03	high_impact	0.44	0.8	72.41	11.91	0.56	P	0.80	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9797	9797	T	A	MI.7888	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	591	197	F	L	ttT/ttA	5.68	1	0	probably_damaging	0.98	neutral	0.39	neutral	1.55	deleterious	-4	deleterious	-5.71	high_impact	4.44	0.64	neutral	0.03	damaging	4.53	24.30	deleterious	0.04	0.35	0.59	disease	0.83	disease	0.74	disease	0.76	disease	5	0.99	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-2.51	low_impact	0.08	medium_impact	2.8	high_impact	0.56	0.8	72.41	11.91	0.63	P	0.92	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9797	9797	T	G	MI.7889	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	591	197	F	L	ttT/ttG	5.68	1	0	probably_damaging	0.98	neutral	0.39	neutral	1.55	deleterious	-4	deleterious	-5.71	high_impact	4.44	0.64	neutral	0.03	damaging	4.34	24.00	deleterious	0.04	0.35	0.59	disease	0.83	disease	0.74	disease	0.76	disease	5	0.99	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-2.51	low_impact	0.08	medium_impact	2.8	high_impact	0.56	0.8	72.41	11.91	0.63	P	0.92	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8896	8896	G	T	MI.789	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	370	124	A	S	Gcc/Tcc	-6.12	0	0	benign	0.01	neutral	0.78	neutral	3.91	neutral	-0.14	neutral	1.04	neutral_impact	0.06	0.86	neutral	0.92	neutral	-0.95	0.02	neutral	0.43	0.65	0.31	neutral	0.21	neutral	0.19	neutral	0.38	neutral	2	0.19	neutral	0.89	deleterious	-6	neutral	0.15	neutral	1.14	medium_impact	0.6	medium_impact	-1.05	low_impact	0.80	0.9	19.91	7.92	0.34	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9798	9798	T	A	MI.7890	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	592	198	F	I	Ttt/Att	-3.11	0	0	benign	0.3	neutral	0.08	neutral	1.68	deleterious	-6.43	deleterious	-5.58	high_impact	4.17	0.67	neutral	0.03	damaging	4.21	23.90	deleterious	0.05	0.35	0.7	disease	0.84	disease	0.71	disease	0.76	disease	5	0.91	neutral	0.39	neutral	-2	neutral	0.57	deleterious	-0.51	medium_impact	-0.41	medium_impact	2.55	high_impact	0.38	0.8	75.1	11.32	0.32	N	0.96	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9798	9798	T	G	MI.7891	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	592	198	F	V	Ttt/Gtt	-3.11	0	0	benign	0.4	neutral	0.22	neutral	1.68	deleterious	-6.78	deleterious	-6.47	high_impact	4.51	0.63	neutral	0.03	damaging	3.85	23.40	deleterious	0.04	0.35	0.69	disease	0.89	disease	0.72	disease	0.78	disease	6	0.74	neutral	0.41	neutral	-2	neutral	0.57	deleterious	-0.7	medium_impact	-0.12	medium_impact	2.86	high_impact	0.34	0.8	75.1	11.32	0.37	N	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9798	9798	T	C	MI.7892	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	592	198	F	L	Ttt/Ctt	-3.11	0	0	benign	0.16	neutral	0.21	neutral	1.7	deleterious	-5.47	deleterious	-5.58	high_impact	4.51	0.62	neutral	0.03	damaging	3.64	23.20	deleterious	0.03	0.35	0.47	neutral	0.81	disease	0.65	disease	0.67	disease	3	0.76	neutral	0.53	deleterious	-2	neutral	0.39	neutral	-0.17	medium_impact	-0.14	medium_impact	2.86	high_impact	0.56	0.8	75.1	11.32	0.38	N	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9799	9799	T	G	MI.7893	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	593	198	F	C	tTt/tGt	5.68	1	0	probably_damaging	0.94	deleterious	0.04	neutral	1.68	deleterious	-7.41	deleterious	-7.42	high_impact	4.51	0.7	neutral	0.03	damaging	4.11	23.80	deleterious	0.02	0.35	0.89	disease	0.9	disease	0.73	disease	0.82	disease	6	0.99	deleterious	0.05	neutral	6	deleterious	0.85	deleterious	-2.03	low_impact	-0.6	medium_impact	2.86	high_impact	0.23	0.8	75.1	11.32	0.48	N	0.98	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9799	9799	T	C	MI.7894	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	593	198	F	S	tTt/tCt	5.68	1	0	possibly_damaging	0.69	neutral	0.21	neutral	1.68	deleterious	-6.62	deleterious	-7.42	high_impact	3.7	0.66	neutral	0.02	damaging	4.18	23.80	deleterious	0.02	0.35	0.77	disease	0.85	disease	0.7	disease	0.7	disease	4	0.83	neutral	0.26	neutral	1	deleterious	0.73	deleterious	-1.21	low_impact	-0.14	medium_impact	2.13	high_impact	0.28	0.8	75.1	11.32	0.52	N	0.96	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9799	9799	T	A	MI.7895	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	593	198	F	Y	tTt/tAt	5.68	1	0	benign	0.01	neutral	0.23	neutral	2.3	neutral	-0.68	neutral	-2.41	low_impact	1.21	0.56	damaging	0.14	damaging	2.20	17.52	deleterious	0.11	0.4	0.11	neutral	0.58	disease	0.5	neutral	0.41	neutral	2	0.77	neutral	0.61	deleterious	-6	neutral	0.18	neutral	1.07	medium_impact	-0.11	medium_impact	-0.1	medium_impact	0.52	0.8	75.1	11.32	0.5	P	0.80	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9800	9800	T	A	MI.7896	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	594	198	F	L	ttT/ttA	7.53	1	0	benign	0.16	neutral	0.21	neutral	1.7	deleterious	-5.47	deleterious	-5.58	high_impact	4.51	0.62	neutral	0.03	damaging	4.16	23.80	deleterious	0.03	0.35	0.47	neutral	0.81	disease	0.65	disease	0.67	disease	3	0.76	neutral	0.53	deleterious	-2	neutral	0.39	neutral	-0.17	medium_impact	-0.14	medium_impact	2.86	high_impact	0.56	0.8	75.1	11.32	0.53	P	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9800	9800	T	G	MI.7897	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	594	198	F	L	ttT/ttG	7.53	1	0	benign	0.16	neutral	0.21	neutral	1.7	deleterious	-5.47	deleterious	-5.58	high_impact	4.51	0.62	neutral	0.03	damaging	4.06	23.70	deleterious	0.03	0.35	0.47	neutral	0.81	disease	0.65	disease	0.67	disease	3	0.76	neutral	0.53	deleterious	-2	neutral	0.39	neutral	-0.17	medium_impact	-0.14	medium_impact	2.86	high_impact	0.56	0.8	75.1	11.32	0.53	P	0.92	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9801	9801	G	C	MI.7898	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	595	199	V	L	Gta/Cta	-3.8	0	0	benign	0	neutral	0.61	neutral	2.41	neutral	0.51	neutral	-1.16	neutral_impact	0.74	0.58	damaging	0.69	neutral	1.63	14.04	neutral	0.16	0.45	0.14	neutral	0.59	disease	0.32	neutral	0.43	neutral	1	0.38	neutral	0.81	deleterious	-6	neutral	0.16	neutral	2.05	high_impact	0.3	medium_impact	-0.52	medium_impact	0.40	0.8	16.48	24.65	0.34	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9801	9801	G	T	MI.7899	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	595	199	V	L	Gta/Tta	-3.8	0	0	benign	0	neutral	0.61	neutral	2.41	neutral	0.51	neutral	-1.16	neutral_impact	0.74	0.58	damaging	0.69	neutral	1.80	14.96	neutral	0.16	0.45	0.14	neutral	0.59	disease	0.32	neutral	0.43	neutral	1	0.38	neutral	0.81	deleterious	-6	neutral	0.16	neutral	2.05	high_impact	0.3	medium_impact	-0.52	medium_impact	0.40	0.8	16.48	24.65	0.34	N	0.36	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8561	8561	C	G	MI.79	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	35	12	P	R	cCc/cGc	7.3	1	0	probably_damaging	1	deleterious	0.02	neutral	4.64	neutral	0.07	deleterious	-7.81	medium_impact	3.02	0.62	neutral	0.06	damaging	3.37	22.90	deleterious	0.31	0.65	0.54	disease	0.92	disease	0.78	disease	0.83	disease	7	1	deleterious	0.01	neutral	5	deleterious	0.83	deleterious	-3.6	low_impact	-0.66	medium_impact	1.49	medium_impact	0.58	0.9	50	8.94	0.46	N	0.72	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	C8561G	Ataxia w neuropathy, DM, SNHL, and hypogonadism	+	+	Reported	1	.	P	P	damaging
chrM	8897	8897	C	A	MI.790	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	371	124	A	D	gCc/gAc	1.52	0.6	0	benign	0.16	neutral	0.15	neutral	3.83	deleterious	-3.06	neutral	-2.21	medium_impact	3.21	0.75	neutral	0.47	neutral	2.69	20.70	deleterious	0.3	0.65	0.64	disease	0.89	disease	0.71	disease	0.75	disease	5	0.83	neutral	0.5	deleterious	-3	neutral	0.44	deleterious	-0.07	medium_impact	-0.13	medium_impact	1.65	medium_impact	0.54	0.9	19.91	7.92	0.31	N	0.23	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9801	9801	G	A	MI.7900	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	595	199	V	M	Gta/Ata	-3.8	0	0	benign	0.02	neutral	0.26	neutral	2.24	neutral	-0.22	neutral	-0.33	neutral_impact	0.5	0.69	neutral	0.77	neutral	0.31	5.80	deleterious	0.18	0.45	0.29	neutral	0.12	neutral	0.28	neutral	0.25	neutral	5	0.73	neutral	0.62	deleterious	-6	neutral	0.13	neutral	0.77	medium_impact	-0.07	medium_impact	-0.73	medium_impact	0.65	0.8	16.48	24.65	0.54	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9802	9802	T	G	MI.7901	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	596	199	V	G	gTa/gGa	0.36	0.09	0	possibly_damaging	0.49	neutral	0.51	neutral	2.12	deleterious	-3.06	deleterious	-5.56	medium_impact	2.56	0.59	damaging	0.56	neutral	3.82	23.40	deleterious	0.03	0.35	0.49	neutral	0.8	disease	0.6	disease	0.71	disease	4	0.48	neutral	0.51	deleterious	0	NA	0.59	deleterious	-0.85	medium_impact	0.2	medium_impact	1.11	medium_impact	0.25	0.8	16.48	24.65	0.33	N	0.73	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9802	9802	T	A	MI.7902	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	596	199	V	E	gTa/gAa	0.36	0.09	0	benign	0.3	neutral	0.25	neutral	2.13	deleterious	-3.61	deleterious	-4.61	high_impact	3.81	0.55	damaging	0.42	neutral	4.45	24.20	deleterious	0.02	0.35	0.5	disease	0.89	disease	0.72	disease	0.79	disease	6	0.7	neutral	0.48	deleterious	-2	neutral	0.48	deleterious	-0.51	medium_impact	-0.08	medium_impact	2.23	high_impact	0.22	0.8	16.48	24.65	0.47	N	0.87	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9802	9802	T	C	MI.7903	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	596	199	V	A	gTa/gCa	0.36	0.09	0	benign	0.15	neutral	0.6	neutral	2.23	neutral	-1.02	deleterious	-3.04	medium_impact	1.97	0.6	damaging	0.58	neutral	2.04	16.49	deleterious	0.08	0.35	0.18	neutral	0.59	disease	0.49	neutral	0.45	neutral	1	0.29	neutral	0.73	deleterious	-3	neutral	0.21	neutral	-0.14	medium_impact	0.29	medium_impact	0.58	medium_impact	0.16	0.8	16.48	24.65	0.36	N	0.55	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9804	9804	G	C	MI.7904	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	598	200	A	P	Gcc/Ccc	-4.5	0	0.01	probably_damaging	0.93	neutral	0.2	neutral	2.44	deleterious	-3.29	deleterious	-4.49	high_impact	4.29	0.58	damaging	0.36	neutral	3.89	23.50	deleterious	0.02	0.35	0.51	disease	0.91	disease	0.75	disease	0.8	disease	6	0.96	neutral	0.14	neutral	2	deleterious	0.84	deleterious	-1.96	low_impact	-0.15	medium_impact	2.66	high_impact	0.59	0.8	73.95	10.14	0.49	N	0.94	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9804	9804	G	A	MI.7905	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	598	200	A	T	Gcc/Acc	-4.5	0	0.01	benign	0.01	neutral	0.47	neutral	2.54	neutral	-0.32	deleterious	-3.26	medium_impact	2.1	0.19	damaging	0.31	neutral	2.33	18.38	deleterious	0.16	0.45	0.2	neutral	0.78	disease	0.43	neutral	0.5	disease	0	0.52	neutral	0.73	deleterious	-3	neutral	0.25	neutral	1.07	medium_impact	0.16	medium_impact	0.7	medium_impact	0.71	0.85	73.95	10.14	0.86	P	0.85	disease_causing_automatic	0	0.08	rs200613617	Pathogenic	Leber's_optic_atrophy	24691	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	pancreatic cancer cell line	.	CPD	3.26	G9804A	LHON	+	-	Reported	8	P	P	P	damaging
chrM	9804	9804	G	T	MI.7906	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	598	200	A	S	Gcc/Tcc	-4.5	0	0.01	benign	0.24	neutral	0.41	neutral	2.47	neutral	-1.64	deleterious	-2.53	medium_impact	2.5	0.46	damaging	0.58	neutral	2.19	17.41	deleterious	0.2	0.45	0.23	neutral	0.79	disease	0.44	neutral	0.5	disease	0	0.5	neutral	0.59	deleterious	-3	neutral	0.30	neutral	-0.38	medium_impact	0.1	medium_impact	1.06	medium_impact	0.44	0.8	73.95	10.14	0.45	N	0.49	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9805	9805	C	A	MI.7907	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	599	200	A	D	gCc/gAc	4.29	1	0	probably_damaging	0.91	neutral	0.22	neutral	2.43	deleterious	-4	deleterious	-5.35	high_impact	4.29	0.65	neutral	0.36	neutral	4.69	24.60	deleterious	0.01	0.35	0.48	neutral	0.94	disease	0.73	disease	0.85	disease	7	0.94	neutral	0.16	neutral	2	deleterious	0.80	deleterious	-1.85	low_impact	-0.12	medium_impact	2.66	high_impact	0.39	0.8	73.95	10.14	0.55	P	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9805	9805	C	G	MI.7908	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	599	200	A	G	gCc/gGc	4.29	1	0	benign	0.1	neutral	0.42	neutral	2.45	neutral	-2.4	deleterious	-3.64	medium_impact	2.82	0.53	damaging	0.54	neutral	2.29	18.11	deleterious	0.13	0.4	0.35	neutral	0.8	disease	0.61	disease	0.54	disease	1	0.52	neutral	0.66	deleterious	-3	neutral	0.28	neutral	0.06	medium_impact	0.11	medium_impact	1.35	medium_impact	0.66	0.8	73.95	10.14	0.48	N	0.66	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9805	9805	C	T	MI.7909	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	599	200	A	V	gCc/gTc	4.29	1	0	benign	0.16	neutral	0.58	neutral	2.51	neutral	-0.48	deleterious	-3.58	high_impact	3.73	0.55	damaging	0.43	neutral	2.84	21.60	deleterious	0.1	0.4	0.17	neutral	0.9	disease	0.64	disease	0.72	disease	4	0.31	neutral	0.71	deleterious	-2	neutral	0.51	deleterious	-0.17	medium_impact	0.27	medium_impact	2.16	high_impact	0.68	0.85	73.95	10.14	0.53	P	0.49	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8897	8897	C	G	MI.791	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	371	124	A	G	gCc/gGc	1.52	0.6	0	benign	0.11	neutral	0.24	neutral	3.85	neutral	-0.34	neutral	-1.77	medium_impact	2.51	0.76	neutral	0.58	neutral	2.17	17.32	deleterious	0.39	0.65	0.43	neutral	0.69	disease	0.57	disease	0.68	disease	4	0.73	neutral	0.57	deleterious	-3	neutral	0.25	neutral	0.11	medium_impact	0.01	medium_impact	1.05	medium_impact	0.74	0.9	19.91	7.92	0.34	N	0.27	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9807	9807	A	T	MI.7910	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	601	201	T	S	Aca/Tca	-13.06	0	0	probably_damaging	0.95	neutral	0.4	neutral	1.92	deleterious	-3.66	deleterious	-3.71	high_impact	4.43	0.68	neutral	0.03	damaging	3.50	23.10	deleterious	0.17	0.45	0.43	neutral	0.8	disease	0.76	disease	0.74	disease	5	0.95	neutral	0.23	neutral	2	deleterious	0.77	deleterious	-2.11	low_impact	0.09	medium_impact	2.79	high_impact	0.76	0.85	73.95	11.6	0.46	N	0.77	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9807	9807	A	C	MI.7911	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	601	201	T	P	Aca/Cca	-13.06	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.88	deleterious	-5.92	deleterious	-5.62	high_impact	4.79	0.64	neutral	0.05	damaging	3.59	23.20	deleterious	0.03	0.35	0.69	disease	0.86	disease	0.86	disease	0.81	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.15	medium_impact	3.11	high_impact	0.48	0.8	73.95	11.6	0.6	P	0.98	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9807	9807	A	G	MI.7912	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	601	201	T	A	Aca/Gca	-13.06	0	0	probably_damaging	0.95	neutral	0.52	neutral	1.93	deleterious	-3.47	deleterious	-4.63	high_impact	4.43	0.65	neutral	0.04	damaging	3.56	23.10	deleterious	0.07	0.35	0.29	neutral	0.75	disease	0.76	disease	0.73	disease	5	0.95	neutral	0.29	neutral	2	deleterious	0.72	deleterious	-2.11	low_impact	0.21	medium_impact	2.79	high_impact	0.50	0.8	73.95	11.6	0.44	N	0.44	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9808	9808	C	A	MI.7913	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	602	201	T	K	aCa/aAa	5.68	1	0	probably_damaging	0.99	neutral	0.29	neutral	1.89	deleterious	-4.76	deleterious	-5.59	high_impact	4.79	0.68	neutral	0.02	damaging	4.57	24.40	deleterious	0.05	0.35	0.54	disease	0.91	disease	0.85	disease	0.83	disease	7	0.99	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.03	medium_impact	3.11	high_impact	0.41	0.8	73.95	11.6	0.75	P	0.99	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9808	9808	C	T	MI.7914	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	602	201	T	M	aCa/aTa	5.68	1	0	probably_damaging	1	neutral	0.23	neutral	1.88	deleterious	-5.03	deleterious	-5.62	high_impact	4.43	0.68	neutral	0.01	damaging	4.15	23.80	deleterious	0.05	0.35	0.59	disease	0.85	disease	0.8	disease	0.78	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.11	medium_impact	2.79	high_impact	0.58	0.8	73.95	11.6	0.57	P	0.96	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9810	9810	G	C	MI.7915	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	604	202	G	R	Ggc/Cgc	-4.96	0	0	probably_damaging	1	neutral	0.35	neutral	0.9	deleterious	-6.58	deleterious	-7.57	high_impact	4.79	0.63	neutral	0.02	damaging	4.06	23.70	deleterious	0.02	0.35	0.77	disease	0.94	disease	0.84	disease	0.88	disease	8	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.78	low_impact	0.04	medium_impact	3.11	high_impact	0.67	0.85	72.8	11.69	0.58	P	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9810	9810	G	T	MI.7916	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	604	202	G	C	Ggc/Tgc	-4.96	0	0	probably_damaging	1	neutral	0.18	neutral	0.89	deleterious	-7.58	deleterious	-8.51	high_impact	4.44	0.56	damaging	0.02	damaging	4.24	23.90	deleterious	0.03	0.35	0.87	disease	0.94	disease	0.77	disease	0.87	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.78	low_impact	-0.18	medium_impact	2.8	high_impact	0.24	0.8	72.8	11.69	0.44	N	0.98	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9810	9810	G	A	MI.7917	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	604	202	G	S	Ggc/Agc	-4.96	0	0	probably_damaging	1	neutral	0.44	neutral	0.94	deleterious	-5.26	deleterious	-5.64	high_impact	4.09	0.56	damaging	0.02	damaging	4.27	23.90	deleterious	0.04	0.35	0.56	disease	0.88	disease	0.73	disease	0.77	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	0.13	medium_impact	2.48	high_impact	0.65	0.8	72.8	11.69	0.28	N	0.85	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9811	9811	G	A	MI.7918	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	605	202	G	D	gGc/gAc	7.3	1	0	probably_damaging	1	neutral	0.25	neutral	0.91	deleterious	-6.07	deleterious	-6.62	high_impact	4.79	0.49	damaging	0.02	damaging	3.96	23.60	deleterious	0.02	0.35	0.62	disease	0.92	disease	0.83	disease	0.85	disease	7	1	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.08	medium_impact	3.11	high_impact	0.11	0.8	72.8	11.69	0.66	P	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9811	9811	G	T	MI.7919	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	605	202	G	V	gGc/gTc	7.3	1	0	probably_damaging	1	neutral	0.68	neutral	0.9	deleterious	-6.37	deleterious	-8.52	high_impact	4.79	0.52	damaging	0.01	damaging	3.86	23.50	deleterious	0.02	0.35	0.76	disease	0.94	disease	0.79	disease	0.88	disease	8	1	deleterious	0.34	neutral	2	deleterious	0.89	deleterious	-3.78	low_impact	0.38	medium_impact	3.11	high_impact	0.20	0.8	72.8	11.69	0.59	P	0.97	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8897	8897	C	T	MI.792	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	371	124	A	V	gCc/gTc	1.52	0.6	0	benign	0.11	neutral	0.4	neutral	3.92	neutral	0	deleterious	-2.74	low_impact	1.88	0.79	neutral	0.66	neutral	2.63	20.40	deleterious	0.3	0.65	0.4	neutral	0.72	disease	0.46	neutral	0.24	neutral	5	0.54	neutral	0.65	deleterious	-6	neutral	0.25	neutral	0.11	medium_impact	0.19	medium_impact	0.51	medium_impact	0.72	0.9	19.91	7.92	0.28	N	0.31	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9811	9811	G	C	MI.7920	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	605	202	G	A	gGc/gCc	7.3	1	0	probably_damaging	1	neutral	0.62	neutral	0.95	deleterious	-4.99	deleterious	-5.66	high_impact	4.09	0.57	damaging	0.01	damaging	3.21	22.70	deleterious	0.05	0.35	0.53	disease	0.81	disease	0.73	disease	0.74	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	0.31	medium_impact	2.48	high_impact	0.47	0.8	72.8	11.69	0.48	N	0.30	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9813	9813	T	C	MI.7921	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	607	203	F	L	Ttc/Ctc	-5.19	0	0	probably_damaging	0.95	neutral	0.66	neutral	2.26	neutral	-0.22	deleterious	-5.63	medium_impact	2.58	0.58	damaging	0.54	neutral	4.21	23.90	deleterious	0.25	0.45	0.13	neutral	0.72	disease	0.49	neutral	0.48	neutral	0	0.94	neutral	0.36	neutral	1	deleterious	0.71	deleterious	-2.11	low_impact	0.36	medium_impact	1.13	medium_impact	0.59	0.8	74.33	11.75	0.26	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9813	9813	T	A	MI.7922	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	607	203	F	I	Ttc/Atc	-5.19	0	0	probably_damaging	0.97	neutral	0.4	neutral	1.98	neutral	-2.1	deleterious	-5.64	high_impact	3.83	0.64	neutral	0.58	neutral	4.56	24.40	deleterious	0.14	0.4	0.2	neutral	0.86	disease	0.68	disease	0.72	disease	4	0.97	neutral	0.22	neutral	2	deleterious	0.76	deleterious	-2.34	low_impact	0.09	medium_impact	2.25	high_impact	0.30	0.8	74.33	11.75	0.39	N	0.96	polymorphism	1	0.14	.	not_provided	not_provided	434784	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9813	9813	T	G	MI.7923	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	607	203	F	V	Ttc/Gtc	-5.19	0	0	probably_damaging	0.98	neutral	0.49	neutral	1.97	neutral	-2.24	deleterious	-6.59	high_impact	4.72	0.58	damaging	0.49	neutral	4.26	23.90	deleterious	0.09	0.35	0.21	neutral	0.9	disease	0.68	disease	0.73	disease	5	0.98	deleterious	0.26	neutral	2	deleterious	0.76	deleterious	-2.51	low_impact	0.18	medium_impact	3.05	high_impact	0.19	0.8	74.33	11.75	0.56	P	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9814	9814	T	A	MI.7924	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	608	203	F	Y	tTc/tAc	7.53	1	0	probably_damaging	0.95	neutral	1	neutral	1.94	neutral	-2.61	deleterious	-2.84	high_impact	4.72	0.66	neutral	0.37	neutral	4.39	24.10	deleterious	0.16	0.45	0.44	neutral	0.84	disease	0.7	disease	0.73	disease	5	0.95	neutral	0.53	deleterious	2	deleterious	0.78	deleterious	-2.11	low_impact	1.9	high_impact	3.05	high_impact	0.49	0.8	74.33	11.75	0.7	P	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9814	9814	T	G	MI.7925	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	608	203	F	C	tTc/tGc	7.53	1	0	probably_damaging	1	neutral	0.17	neutral	1.87	deleterious	-5.41	deleterious	-7.55	high_impact	4.72	0.63	neutral	0.41	neutral	4.24	23.90	deleterious	0.04	0.35	0.57	disease	0.89	disease	0.71	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.2	medium_impact	3.05	high_impact	0.12	0.8	74.33	11.75	0.62	P	0.98	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9814	9814	T	C	MI.7926	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	608	203	F	S	tTc/tCc	7.53	1	0	probably_damaging	0.99	neutral	0.4	neutral	1.89	deleterious	-4.07	deleterious	-7.56	high_impact	4.37	0.72	neutral	0.55	neutral	4.38	24.10	deleterious	0.03	0.35	0.34	neutral	0.86	disease	0.67	disease	0.72	disease	4	0.99	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-2.81	low_impact	0.09	medium_impact	2.73	high_impact	0.14	0.8	74.33	11.75	0.56	P	0.96	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9815	9815	C	A	MI.7927	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	609	203	F	L	ttC/ttA	5.68	1	0	probably_damaging	0.95	neutral	0.66	neutral	2.26	neutral	-0.22	deleterious	-5.63	medium_impact	2.58	0.58	damaging	0.54	neutral	4.76	24.70	deleterious	0.25	0.45	0.13	neutral	0.72	disease	0.49	neutral	0.48	neutral	0	0.94	neutral	0.36	neutral	1	deleterious	0.71	deleterious	-2.11	low_impact	0.36	medium_impact	1.13	medium_impact	0.59	0.8	74.33	11.75	0.43	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9815	9815	C	G	MI.7928	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	609	203	F	L	ttC/ttG	5.68	1	0	probably_damaging	0.95	neutral	0.66	neutral	2.26	neutral	-0.22	deleterious	-5.63	medium_impact	2.58	0.58	damaging	0.54	neutral	4.48	24.20	deleterious	0.25	0.45	0.13	neutral	0.72	disease	0.49	neutral	0.48	neutral	0	0.94	neutral	0.36	neutral	1	deleterious	0.71	deleterious	-2.11	low_impact	0.36	medium_impact	1.13	medium_impact	0.59	0.8	74.33	11.75	0.42	N	0.92	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9816	9816	C	A	MI.7929	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	610	204	H	N	Cac/Aac	-3.11	0	0	probably_damaging	0.99	neutral	0.31	deleterious	-1.84	deleterious	-11.11	deleterious	-6.58	high_impact	4.79	0.62	neutral	0.02	damaging	3.99	23.60	deleterious	0.08	0.35	0.85	disease	0.83	disease	0.82	disease	0.84	disease	7	0.99	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.01	medium_impact	3.11	high_impact	0.20	0.8	73.95	11.69	0.53	N	0.96	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8899	8899	C	A	MI.793	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	373	125	L	M	Cta/Ata	-7.74	0	0	possibly_damaging	0.86	neutral	0.08	neutral	4.09	deleterious	-4.66	neutral	-1.78	medium_impact	2.68	0.76	neutral	0.61	neutral	3.68	23.30	deleterious	0.31	0.65	0.74	disease	0.55	disease	0.55	disease	0.51	disease	0	0.96	neutral	0.11	neutral	0	NA	0.70	deleterious	-1.5	low_impact	-0.31	medium_impact	1.2	medium_impact	0.63	0.9	48.23	8.39	0.34	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9816	9816	C	G	MI.7930	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	610	204	H	D	Cac/Gac	-3.11	0	0	probably_damaging	1	neutral	0.2	deleterious	-1.85	deleterious	-13.06	deleterious	-8.47	high_impact	4.79	0.64	neutral	0.01	damaging	3.98	23.60	deleterious	0.04	0.35	0.82	disease	0.85	disease	0.87	disease	0.83	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.15	medium_impact	3.11	high_impact	0.20	0.8	73.95	11.69	0.44	N	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9816	9816	C	T	MI.7931	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	610	204	H	Y	Cac/Tac	-3.11	0	0	probably_damaging	0.99	neutral	1	deleterious	-1.84	deleterious	-10.91	deleterious	-5.65	high_impact	4.45	0.64	neutral	0.02	damaging	3.81	23.40	deleterious	0.04	0.35	0.8	disease	0.89	disease	0.81	disease	0.84	disease	7	0.99	deleterious	0.51	deleterious	2	deleterious	0.88	deleterious	-2.81	low_impact	1.9	high_impact	2.81	high_impact	0.21	0.8	73.95	11.69	0.41	N	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9817	9817	A	T	MI.7932	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	611	204	H	L	cAc/cTc	7.3	1	0	probably_damaging	1	neutral	0.66	deleterious	-1.86	deleterious	-14.23	deleterious	-10.36	high_impact	4.79	0.6	damaging	0.02	damaging	3.95	23.60	deleterious	0.03	0.35	0.84	disease	0.9	disease	0.81	disease	0.84	disease	7	1	deleterious	0.33	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	0.36	medium_impact	3.11	high_impact	0.17	0.8	73.95	11.69	0.56	P	0.96	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9817	9817	A	C	MI.7933	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	611	204	H	P	cAc/cCc	7.3	1	0	probably_damaging	1	neutral	0.2	deleterious	-1.85	deleterious	-13.42	deleterious	-9.42	high_impact	4.79	0.61	neutral	0.02	damaging	3.33	22.90	deleterious	0.03	0.35	0.89	disease	0.87	disease	0.88	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.78	low_impact	-0.15	medium_impact	3.11	high_impact	0.14	0.8	73.95	11.69	0.53	P	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9817	9817	A	G	MI.7934	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	611	204	H	R	cAc/cGc	7.3	1	0	probably_damaging	1	neutral	0.35	deleterious	-1.85	deleterious	-12.68	deleterious	-7.5	high_impact	4.79	0.72	neutral	0.02	damaging	3.10	22.50	deleterious	0.04	0.35	0.81	disease	0.88	disease	0.85	disease	0.85	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.78	low_impact	0.04	medium_impact	3.11	high_impact	0.33	0.8	73.95	11.69	0.58	P	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9818	9818	C	A	MI.7935	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	612	204	H	Q	caC/caA	8.69	1	0	probably_damaging	1	neutral	0.29	deleterious	-1.85	deleterious	-11.93	deleterious	-7.49	high_impact	4.24	0.65	neutral	0.02	damaging	4.03	23.60	deleterious	0.05	0.35	0.86	disease	0.83	disease	0.82	disease	0.84	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.03	medium_impact	2.62	high_impact	0.30	0.8	73.95	11.69	0.54	P	0.94	polymorphism	1	0.34	rs2854139	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9818	9818	C	G	MI.7936	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	612	204	H	Q	caC/caG	8.69	1	0	probably_damaging	1	neutral	0.29	deleterious	-1.85	deleterious	-11.93	deleterious	-7.49	high_impact	4.24	0.65	neutral	0.02	damaging	3.65	23.20	deleterious	0.05	0.35	0.86	disease	0.83	disease	0.82	disease	0.84	disease	7	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.03	medium_impact	2.62	high_impact	0.30	0.8	73.95	11.69	0.53	P	0.94	polymorphism	1	0.34	rs2854139	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9819	9819	G	C	MI.7937	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	613	205	G	R	Gga/Cga	-6.35	0	0	probably_damaging	1	neutral	0.12	neutral	1.9	deleterious	-4.94	deleterious	-7.51	high_impact	4.77	0.66	neutral	0.03	damaging	4.06	23.70	deleterious	0.02	0.35	0.58	disease	0.91	disease	0.78	disease	0.81	disease	6	1	deleterious	0.06	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.3	medium_impact	3.09	high_impact	0.36	0.8	74.33	11.77	0.58	P	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9819	9819	G	T	MI.7938	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	613	205	G	W	Gga/Tga	-6.35	0	0	probably_damaging	1	neutral	0.07	neutral	1.88	deleterious	-6.56	deleterious	-7.56	high_impact	4.77	0.64	neutral	0.02	damaging	4.52	24.30	deleterious	0.04	0.35	0.87	disease	0.9	disease	0.74	disease	0.82	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.89	deleterious	-3.78	low_impact	-0.45	medium_impact	3.09	high_impact	0.12	0.8	74.33	11.77	0.53	N	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9820	9820	G	A	MI.7939	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	614	205	G	E	gGa/gAa	6.14	1	0	probably_damaging	1	neutral	0.09	neutral	1.9	deleterious	-4.9	deleterious	-7.54	high_impact	4.77	0.58	damaging	0.01	damaging	3.93	23.50	deleterious	0.02	0.35	0.5	disease	0.88	disease	0.77	disease	0.79	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.38	medium_impact	3.09	high_impact	0.25	0.8	74.33	11.77	0.66	P	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8899	8899	C	G	MI.794	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	373	125	L	V	Cta/Gta	-7.74	0	0	benign	0.28	deleterious	0.03	neutral	4.1	deleterious	-3.67	deleterious	-2.69	medium_impact	2.42	0.71	neutral	0.52	neutral	1.68	14.28	neutral	0.26	0.65	0.38	neutral	0.59	disease	0.55	disease	0.43	neutral	2	0.97	neutral	0.38	neutral	1	deleterious	0.38	neutral	-0.37	medium_impact	-0.56	medium_impact	0.98	medium_impact	0.61	0.9	48.23	8.39	0.39	N	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9820	9820	G	C	MI.7940	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	614	205	G	A	gGa/gCa	6.14	1	0	probably_damaging	0.99	neutral	0.2	neutral	2.02	neutral	-2.52	deleterious	-5.66	medium_impact	3.27	0.59	damaging	0	damaging	3.20	22.70	deleterious	0.09	0.35	0.35	neutral	0.71	disease	0.66	disease	0.67	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.79	deleterious	-2.81	low_impact	-0.15	medium_impact	1.75	medium_impact	0.48	0.8	74.33	11.77	0.43	N	0.30	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9820	9820	G	T	MI.7941	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	614	205	G	V	gGa/gTa	6.14	1	0	probably_damaging	1	neutral	0.29	neutral	1.92	deleterious	-4.05	deleterious	-8.51	high_impact	4.42	0.54	damaging	0.02	damaging	3.83	23.40	deleterious	0.03	0.35	0.46	neutral	0.9	disease	0.72	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.03	medium_impact	2.78	high_impact	0.22	0.8	74.33	11.77	0.51	N	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9822	9822	C	A	MI.7942	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	616	206	L	I	Ctt/Att	-13.98	0	0	benign	0.12	neutral	0.36	neutral	2.02	neutral	-1.22	neutral	-1.43	medium_impact	2.26	0.58	damaging	0.71	neutral	3.78	23.40	deleterious	0.3	0.45	0.17	neutral	0.51	disease	0.32	neutral	0.44	neutral	1	0.58	neutral	0.62	deleterious	-3	neutral	0.17	neutral	-0.03	medium_impact	0.05	medium_impact	0.84	medium_impact	0.56	0.8	76.25	10.72	0.48	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9822	9822	C	G	MI.7943	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	616	206	L	V	Ctt/Gtt	-13.98	0	0	benign	0.05	neutral	0.27	neutral	1.94	neutral	-1.83	neutral	-2.29	medium_impact	3.05	0.53	damaging	0.49	neutral	1.78	14.86	neutral	0.25	0.45	0.19	neutral	0.68	disease	0.58	disease	0.6	disease	2	0.71	neutral	0.61	deleterious	-3	neutral	0.17	neutral	0.37	medium_impact	-0.06	medium_impact	1.55	medium_impact	0.61	0.8	76.25	10.72	0.44	N	0.81	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9822	9822	C	T	MI.7944	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	616	206	L	F	Ctt/Ttt	-13.98	0	0	benign	0.01	neutral	0.29	neutral	1.87	neutral	-2.55	deleterious	-3.3	low_impact	1.24	0.53	damaging	0.7	neutral	2.15	17.20	deleterious	0.22	0.45	0.22	neutral	0.46	neutral	0.33	neutral	0.42	neutral	2	0.71	neutral	0.64	deleterious	-6	neutral	0.16	neutral	1.07	medium_impact	-0.03	medium_impact	-0.07	medium_impact	0.61	0.8	76.25	10.72	0.52	N	0.95	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9823	9823	T	A	MI.7945	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	617	206	L	H	cTt/cAt	0.59	0.17	0	possibly_damaging	0.83	neutral	0.15	neutral	1.76	deleterious	-5.84	deleterious	-6.09	high_impact	4.33	0.57	damaging	0.4	neutral	4.36	24.10	deleterious	0.03	0.35	0.54	disease	0.85	disease	0.67	disease	0.72	disease	4	0.92	neutral	0.16	neutral	1	deleterious	0.74	deleterious	-1.54	low_impact	-0.24	medium_impact	2.7	high_impact	0.31	0.8	76.25	10.72	0.42	N	0.97	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9823	9823	T	C	MI.7946	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	617	206	L	P	cTt/cCt	0.59	0.17	0	possibly_damaging	0.88	neutral	0.06	neutral	1.77	deleterious	-5.69	deleterious	-6.12	high_impact	4.33	0.54	damaging	0.4	neutral	4.07	23.70	deleterious	0.01	0.35	0.55	disease	0.88	disease	0.71	disease	0.78	disease	6	0.97	neutral	0.09	neutral	1	deleterious	0.80	deleterious	-1.71	low_impact	-0.49	medium_impact	2.7	high_impact	0.38	0.8	76.25	10.72	0.45	N	0.99	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9823	9823	T	G	MI.7947	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	617	206	L	R	cTt/cGt	0.59	0.17	0	possibly_damaging	0.69	neutral	0.08	neutral	1.77	deleterious	-5.13	deleterious	-5.3	high_impact	4.33	0.57	damaging	0.32	neutral	4.34	24.10	deleterious	0.01	0.35	0.45	neutral	0.92	disease	0.7	disease	0.79	disease	6	0.93	neutral	0.2	neutral	1	deleterious	0.70	deleterious	-1.21	low_impact	-0.41	medium_impact	2.7	high_impact	0.22	0.8	76.25	10.72	0.4	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9825	9825	C	A	MI.7948	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	619	207	H	N	Cac/Aac	-11.9	0	0	probably_damaging	0.99	neutral	0.31	deleterious	-1.6	deleterious	-10.79	deleterious	-6.64	high_impact	4.79	0.59	damaging	0.02	damaging	4.01	23.60	deleterious	0.06	0.35	0.83	disease	0.85	disease	0.76	disease	0.8	disease	6	0.99	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-2.81	low_impact	-0.01	medium_impact	3.11	high_impact	0.19	0.8	73.56	11.76	0.48	N	0.96	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9825	9825	C	G	MI.7949	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	619	207	H	D	Cac/Gac	-11.9	0	0	probably_damaging	1	neutral	0.2	deleterious	-1.6	deleterious	-10.88	deleterious	-8.53	high_impact	4.79	0.59	damaging	0.02	damaging	3.97	23.60	deleterious	0.04	0.35	0.79	disease	0.87	disease	0.82	disease	0.83	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.15	medium_impact	3.11	high_impact	0.17	0.8	73.56	11.76	0.44	N	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8900	8900	T	C	MI.795	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	374	125	L	P	cTa/cCa	-0.57	0	0	probably_damaging	0.9	deleterious	0	neutral	4.08	deleterious	-5.82	deleterious	-6.37	high_impact	3.81	0.44	damaging	0.44	neutral	3.85	23.40	deleterious	0.12	0.65	0.57	disease	0.87	disease	0.8	disease	0.77	disease	5	1	deleterious	0.05	neutral	6	deleterious	0.82	deleterious	-1.66	low_impact	-1.4	low_impact	2.17	high_impact	0.58	0.9	48.23	8.39	0.54	P	1.00	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9825	9825	C	T	MI.7950	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	619	207	H	Y	Cac/Tac	-11.9	0	0	probably_damaging	0.99	neutral	1	deleterious	-1.6	deleterious	-10.91	deleterious	-5.69	high_impact	4.44	0.61	neutral	0.02	damaging	3.82	23.40	deleterious	0.03	0.35	0.77	disease	0.9	disease	0.75	disease	0.8	disease	6	0.99	deleterious	0.51	deleterious	2	deleterious	0.87	deleterious	-2.81	low_impact	1.9	high_impact	2.8	high_impact	0.25	0.8	73.56	11.76	0.34	N	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9826	9826	A	G	MI.7951	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	620	207	H	R	cAc/cGc	5.45	1	0	probably_damaging	0.99	neutral	0.35	deleterious	-1.61	deleterious	-12.31	deleterious	-7.58	high_impact	4.79	0.67	neutral	0.03	damaging	3.07	22.40	deleterious	0.02	0.35	0.78	disease	0.9	disease	0.8	disease	0.8	disease	6	0.99	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-2.81	low_impact	0.04	medium_impact	3.11	high_impact	0.28	0.8	73.56	11.76	0.53	P	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9826	9826	A	T	MI.7952	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	620	207	H	L	cAc/cTc	5.45	1	0	probably_damaging	0.99	neutral	0.71	deleterious	-1.61	deleterious	-13.76	deleterious	-10.44	high_impact	4.79	0.57	damaging	0.02	damaging	3.88	23.50	deleterious	0.02	0.35	0.82	disease	0.91	disease	0.76	disease	0.82	disease	6	0.99	deleterious	0.36	neutral	2	deleterious	0.87	deleterious	-2.81	low_impact	0.41	medium_impact	3.11	high_impact	0.17	0.8	73.56	11.76	0.53	P	0.96	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9826	9826	A	C	MI.7953	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	620	207	H	P	cAc/cCc	5.45	1	0	probably_damaging	1	neutral	0.2	deleterious	-1.61	deleterious	-13.09	deleterious	-9.48	high_impact	4.44	0.58	damaging	0.03	damaging	3.36	22.90	deleterious	0.02	0.35	0.88	disease	0.89	disease	0.84	disease	0.86	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.78	low_impact	-0.15	medium_impact	2.8	high_impact	0.14	0.8	73.56	11.76	0.5	P	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9827	9827	C	A	MI.7954	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	621	207	H	Q	caC/caA	5.68	1	0	probably_damaging	1	neutral	0.29	deleterious	-1.6	deleterious	-11.6	deleterious	-7.57	high_impact	4.79	0.61	neutral	0.02	damaging	4.08	23.70	deleterious	0.03	0.35	0.83	disease	0.85	disease	0.76	disease	0.8	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.03	medium_impact	3.11	high_impact	0.26	0.8	73.56	11.76	0.55	P	0.94	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9827	9827	C	G	MI.7955	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	621	207	H	Q	caC/caG	5.68	1	0	probably_damaging	1	neutral	0.29	deleterious	-1.6	deleterious	-11.6	deleterious	-7.57	high_impact	4.79	0.61	neutral	0.02	damaging	3.71	23.30	deleterious	0.03	0.35	0.83	disease	0.85	disease	0.76	disease	0.8	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.03	medium_impact	3.11	high_impact	0.26	0.8	73.56	11.76	0.55	P	0.94	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9828	9828	G	T	MI.7956	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	622	208	V	F	Gtc/Ttc	-5.89	0	0	probably_damaging	1	neutral	0.45	neutral	1.16	deleterious	-7.17	deleterious	-4.75	high_impact	4.78	0.53	damaging	0.52	neutral	3.92	23.50	deleterious	0.02	0.35	0.68	disease	0.93	disease	0.71	disease	0.81	disease	6	1	deleterious	0.23	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	0.14	medium_impact	3.1	high_impact	0.33	0.8	73.95	11.68	0.61	P	0.94	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9828	9828	G	A	MI.7957	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	622	208	V	I	Gtc/Atc	-5.89	0	0	probably_damaging	0.92	neutral	0.56	neutral	1.3	deleterious	-3.89	neutral	-0.95	high_impact	3.81	0.56	damaging	0.65	neutral	3.77	23.40	deleterious	0.22	0.45	0.24	neutral	0.68	disease	0.6	disease	0.59	disease	2	0.91	neutral	0.32	neutral	2	deleterious	0.68	deleterious	-1.9	low_impact	0.25	medium_impact	2.23	high_impact	0.80	0.85	73.95	11.68	0.37	N	0.21	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9828	9828	G	C	MI.7958	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	622	208	V	L	Gtc/Ctc	-5.89	0	0	probably_damaging	0.92	neutral	1	neutral	1.28	deleterious	-4.17	deleterious	-2.85	high_impact	4.43	0.56	damaging	0.58	neutral	3.68	23.30	deleterious	0.06	0.35	0.34	neutral	0.81	disease	0.65	disease	0.68	disease	4	0.92	neutral	0.54	deleterious	2	deleterious	0.74	deleterious	-1.9	low_impact	1.9	high_impact	2.79	high_impact	0.34	0.8	73.95	11.68	0.38	N	0.68	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9829	9829	T	C	MI.7959	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	623	208	V	A	gTc/gCc	4.29	1	0	probably_damaging	0.99	neutral	0.23	neutral	1.23	deleterious	-4.78	deleterious	-3.8	high_impact	4.22	0.56	damaging	0.67	neutral	3.68	23.30	deleterious	0.03	0.35	0.59	disease	0.7	disease	0.63	disease	0.66	disease	3	0.99	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-2.81	low_impact	-0.11	medium_impact	2.6	high_impact	0.18	0.8	73.95	11.68	0.54	P	0.39	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8900	8900	T	G	MI.796	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	374	125	L	R	cTa/cGa	-0.57	0	0	possibly_damaging	0.86	deleterious	0	neutral	4.08	deleterious	-5.22	deleterious	-5.43	high_impact	4.15	0.52	damaging	0.39	neutral	4.07	23.70	deleterious	0.14	0.65	0.84	disease	0.89	disease	0.79	disease	0.75	disease	5	1	deleterious	0.07	neutral	5	deleterious	0.83	deleterious	-1.5	low_impact	-1.4	low_impact	2.46	high_impact	0.50	0.9	48.23	8.39	0.43	N	0.99	polymorphism	0.9	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9829	9829	T	A	MI.7960	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	623	208	V	D	gTc/gAc	4.29	1	0	probably_damaging	1	neutral	0.08	neutral	1.15	deleterious	-9.71	deleterious	-6.66	high_impact	4.78	0.58	damaging	0.52	neutral	4.59	24.40	deleterious	0.01	0.35	0.89	disease	0.91	disease	0.77	disease	0.84	disease	7	1	deleterious	0.04	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.41	medium_impact	3.1	high_impact	0.15	0.8	73.95	11.68	0.59	P	0.94	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9829	9829	T	G	MI.7961	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	623	208	V	G	gTc/gGc	4.29	1	0	probably_damaging	1	neutral	0.3	neutral	1.16	deleterious	-8.37	deleterious	-6.65	high_impact	4.78	0.56	damaging	0.64	neutral	3.95	23.60	deleterious	0.02	0.35	0.84	disease	0.86	disease	0.68	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.02	medium_impact	3.1	high_impact	0.12	0.8	73.95	11.68	0.6	P	0.88	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9831	9831	A	T	MI.7962	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	625	209	I	F	Att/Ttt	-7.74	0	0	probably_damaging	0.97	neutral	0.54	neutral	2.07	neutral	-1.45	deleterious	-3.08	medium_impact	2.02	0.62	neutral	0.39	neutral	3.87	23.50	deleterious	0.13	0.4	0.48	neutral	0.84	disease	0.43	neutral	0.53	disease	1	0.96	neutral	0.29	neutral	1	deleterious	0.77	deleterious	-2.34	low_impact	0.23	medium_impact	0.63	medium_impact	0.58	0.8	73.95	11.02	0.26	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9831	9831	A	C	MI.7963	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	625	209	I	L	Att/Ctt	-7.74	0	0	possibly_damaging	0.82	neutral	0.88	neutral	2.31	neutral	0.08	neutral	-0.84	neutral_impact	0.42	0.68	neutral	0.76	neutral	2.67	20.60	deleterious	0.17	0.45	0.13	neutral	0.37	neutral	0.34	neutral	0.42	neutral	2	0.8	neutral	0.53	deleterious	-3	neutral	0.35	neutral	-1.51	low_impact	0.69	medium_impact	-0.81	medium_impact	0.54	0.8	73.95	11.02	0.27	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9831	9831	A	G	MI.7964	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	625	209	I	V	Att/Gtt	-7.74	0	0	possibly_damaging	0.63	neutral	0.81	neutral	2.27	neutral	-0.57	neutral	-0.82	medium_impact	2.4	0.66	neutral	0.45	neutral	3.12	22.60	deleterious	0.35	0.5	0.17	neutral	0.5	disease	0.55	disease	0.45	neutral	1	0.55	neutral	0.59	deleterious	0	NA	0.31	neutral	-1.09	low_impact	0.55	medium_impact	0.97	medium_impact	0.42	0.8	73.95	11.02	0.29	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9832	9832	T	C	MI.7965	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	626	209	I	T	aTt/aCt	5.68	1	0	probably_damaging	0.98	neutral	0.48	neutral	2.08	neutral	-0.23	deleterious	-4.03	low_impact	1.79	0.68	neutral	0.45	neutral	3.49	23.10	deleterious	0.06	0.35	0.26	neutral	0.76	disease	0.58	disease	0.67	disease	3	0.98	deleterious	0.25	neutral	-2	neutral	0.72	deleterious	-2.51	low_impact	0.17	medium_impact	0.42	medium_impact	0.30	0.8	73.95	11.02	0.43	N	0.91	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9832	9832	T	G	MI.7966	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	626	209	I	S	aTt/aGt	5.68	1	0	probably_damaging	0.98	neutral	0.37	neutral	2.07	neutral	-1.91	deleterious	-4.86	medium_impact	2.52	0.66	neutral	0.44	neutral	4.38	24.10	deleterious	0.04	0.35	0.51	disease	0.87	disease	0.59	disease	0.71	disease	4	0.98	deleterious	0.2	neutral	1	deleterious	0.81	deleterious	-2.51	low_impact	0.06	medium_impact	1.08	medium_impact	0.24	0.8	73.95	11.02	0.44	N	0.93	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9832	9832	T	A	MI.7967	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	626	209	I	N	aTt/aAt	5.68	1	0	probably_damaging	1	neutral	0.24	neutral	2.04	deleterious	-3.81	deleterious	-5.82	high_impact	3.99	0.61	neutral	0.37	neutral	4.53	24.30	deleterious	0.09	0.4	0.68	disease	0.87	disease	0.62	disease	0.71	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.09	medium_impact	2.39	high_impact	0.26	0.8	73.95	11.02	0.55	P	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9833	9833	T	G	MI.7968	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	627	209	I	M	atT/atG	7.53	1	0.01	probably_damaging	0.99	neutral	0.21	neutral	2.12	neutral	-2.43	neutral	-1.47	low_impact	1.42	0.71	neutral	0.73	neutral	2.27	17.95	deleterious	0.25	0.45	0.46	neutral	0.53	disease	0.39	neutral	0.47	neutral	1	0.99	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-2.81	low_impact	-0.14	medium_impact	0.09	medium_impact	0.52	0.8	73.95	11.02	0.53	P	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9833	9833	T	A	MI.7969	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	627	209	I	M	atT/atA	7.53	1	0.01	probably_damaging	0.99	neutral	0.21	neutral	2.12	neutral	-2.43	neutral	-1.47	low_impact	1.42	0.71	neutral	0.73	neutral	2.59	20.10	deleterious	0.25	0.45	0.46	neutral	0.53	disease	0.39	neutral	0.47	neutral	1	0.99	deleterious	0.11	neutral	-2	neutral	0.70	deleterious	-2.81	low_impact	-0.14	medium_impact	0.09	medium_impact	0.52	0.8	73.95	11.02	0.51	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8900	8900	T	A	MI.797	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	374	125	L	Q	cTa/cAa	-0.57	0	0	probably_damaging	0.9	deleterious	0	neutral	4.08	deleterious	-5.11	deleterious	-5.43	high_impact	4.15	0.58	damaging	0.48	neutral	4.01	23.60	deleterious	0.16	0.65	0.85	disease	0.85	disease	0.69	disease	0.71	disease	4	1	deleterious	0.05	neutral	6	deleterious	0.81	deleterious	-1.66	low_impact	-1.4	low_impact	2.46	high_impact	0.58	0.9	48.23	8.39	0.33	N	0.98	polymorphism	0.92	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9834	9834	A	C	MI.7970	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	628	210	I	L	Att/Ctt	-1.03	0.05	0	possibly_damaging	0.82	neutral	0.56	neutral	2.19	neutral	-0.75	neutral	-1.9	medium_impact	2.19	0.59	damaging	0.04	damaging	3.93	23.50	deleterious	0.17	0.45	0.16	neutral	0.73	disease	0.54	disease	0.59	disease	2	0.8	neutral	0.37	neutral	0	NA	0.41	neutral	-1.51	low_impact	0.25	medium_impact	0.78	medium_impact	0.48	0.8	73.18	11.43	0.22	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9834	9834	A	T	MI.7971	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	628	210	I	F	Att/Ttt	-1.03	0.05	0	probably_damaging	0.97	neutral	0.65	neutral	2.03	neutral	-2.51	deleterious	-3.8	medium_impact	2.85	0.59	damaging	0.02	damaging	3.86	23.50	deleterious	0.12	0.4	0.27	neutral	0.87	disease	0.61	disease	0.71	disease	4	0.96	neutral	0.34	neutral	1	deleterious	0.75	deleterious	-2.34	low_impact	0.35	medium_impact	1.37	medium_impact	0.47	0.8	73.18	11.43	0.2	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9834	9834	A	G	MI.7972	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	628	210	I	V	Att/Gtt	-1.03	0.05	0	possibly_damaging	0.63	neutral	0.48	neutral	2.32	neutral	0	neutral	-0.94	low_impact	1.49	0.5	damaging	0.2	damaging	3.15	22.60	deleterious	0.33	0.5	0.14	neutral	0.31	neutral	0.37	neutral	0.37	neutral	3	0.61	neutral	0.43	neutral	-3	neutral	0.32	neutral	-1.09	low_impact	0.17	medium_impact	0.15	medium_impact	0.39	0.8	73.18	11.43	0.36	N	0.62	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9835	9835	T	G	MI.7973	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	629	210	I	S	aTt/aGt	6.84	1	0	probably_damaging	0.98	neutral	0.28	neutral	2.01	deleterious	-3.16	deleterious	-5.7	high_impact	3.63	0.64	neutral	0.06	damaging	4.32	24.00	deleterious	0.04	0.35	0.37	neutral	0.88	disease	0.6	disease	0.71	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.80	deleterious	-2.51	low_impact	-0.04	medium_impact	2.07	high_impact	0.22	0.8	73.18	11.43	0.45	N	0.93	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9835	9835	T	A	MI.7974	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	629	210	I	N	aTt/aAt	6.84	1	0	probably_damaging	1	neutral	0.11	neutral	1.99	deleterious	-4.26	deleterious	-6.65	high_impact	3.77	0.61	neutral	0.02	damaging	4.36	24.10	deleterious	0.09	0.4	0.55	disease	0.88	disease	0.62	disease	0.71	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.33	medium_impact	2.2	high_impact	0.24	0.8	73.18	11.43	0.45	N	0.97	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9835	9835	T	C	MI.7975	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	629	210	I	T	aTt/aCt	6.84	1	0	probably_damaging	0.98	neutral	0.31	neutral	2.03	neutral	-2.63	deleterious	-4.74	medium_impact	2.66	0.59	damaging	0.02	damaging	3.41	23.00	deleterious	0.09	0.35	0.32	neutral	0.8	disease	0.57	disease	0.66	disease	3	0.99	deleterious	0.17	neutral	1	deleterious	0.76	deleterious	-2.51	low_impact	-0.01	medium_impact	1.2	medium_impact	0.23	0.8	73.18	11.43	0.37	N	0.91	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9836	9836	T	A	MI.7976	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	630	210	I	M	atT/atA	4.76	1	0	probably_damaging	0.99	neutral	0.16	neutral	2.05	neutral	-2.14	deleterious	-2.85	medium_impact	2.33	0.6	neutral	0.03	damaging	3.74	23.30	deleterious	0.2	0.45	0.31	neutral	0.65	disease	0.52	disease	0.45	neutral	1	0.99	deleterious	0.09	neutral	1	deleterious	0.70	deleterious	-2.81	low_impact	-0.22	medium_impact	0.91	medium_impact	0.49	0.8	73.18	11.43	0.41	N	0.66	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9836	9836	T	G	MI.7977	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	630	210	I	M	atT/atG	4.76	1	0	probably_damaging	0.99	neutral	0.16	neutral	2.05	neutral	-2.14	deleterious	-2.85	medium_impact	2.33	0.6	neutral	0.03	damaging	3.49	23.10	deleterious	0.2	0.45	0.31	neutral	0.65	disease	0.52	disease	0.45	neutral	1	0.99	deleterious	0.09	neutral	1	deleterious	0.70	deleterious	-2.81	low_impact	-0.22	medium_impact	0.91	medium_impact	0.49	0.8	73.18	11.43	0.4	N	0.66	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9837	9837	G	C	MI.7978	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	631	211	G	R	Ggc/Cgc	-1.03	0.03	0	probably_damaging	1	neutral	0.33	neutral	-0.4	deleterious	-10.57	deleterious	-7.61	high_impact	4.78	0.57	damaging	0.09	damaging	3.99	23.60	deleterious	0.02	0.35	0.55	disease	0.92	disease	0.8	disease	0.82	disease	6	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.78	low_impact	0.02	medium_impact	3.1	high_impact	0.44	0.8	74.33	11.7	0.47	P	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9837	9837	G	A	MI.7979	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	631	211	G	S	Ggc/Agc	-1.03	0.03	0	probably_damaging	1	neutral	0.43	neutral	-0.39	deleterious	-9.08	deleterious	-5.71	high_impact	4.08	0.62	neutral	0.1	damaging	4.27	24.00	deleterious	0.03	0.35	0.48	neutral	0.84	disease	0.7	disease	0.76	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	0.12	medium_impact	2.47	high_impact	0.38	0.8	74.33	11.7	0.29	N	0.85	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8902	8902	G	T	MI.798	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	376	126	A	S	Gcc/Tcc	-0.1	0.7	0	benign	0.39	neutral	0.65	neutral	4.44	neutral	0.44	neutral	-1.71	low_impact	0.84	0.81	neutral	0.57	neutral	3.68	23.30	deleterious	0.47	0.65	0.3	neutral	0.63	disease	0.28	neutral	0.34	neutral	3	0.32	neutral	0.63	deleterious	-6	neutral	0.45	deleterious	-0.57	medium_impact	0.44	medium_impact	-0.38	medium_impact	0.91	0.95	50.44	8.66	0.22	N	0.65	polymorphism	0.98	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9837	9837	G	T	MI.7980	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	631	211	G	C	Ggc/Tgc	-1.03	0.03	0	probably_damaging	1	neutral	0.2	neutral	-0.4	deleterious	-12.01	deleterious	-8.56	high_impact	4.78	0.54	damaging	0.09	damaging	4.21	23.90	deleterious	0.02	0.35	0.83	disease	0.92	disease	0.72	disease	0.79	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.78	low_impact	-0.15	medium_impact	3.1	high_impact	0.11	0.8	74.33	11.7	0.42	N	0.98	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9838	9838	G	A	MI.7981	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	632	211	G	D	gGc/gAc	9.15	1	0	probably_damaging	1	neutral	0.19	neutral	-0.38	deleterious	-8.46	deleterious	-6.66	high_impact	4.78	0.54	damaging	0.13	damaging	3.91	23.50	deleterious	0.02	0.35	0.53	disease	0.9	disease	0.79	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.17	medium_impact	3.1	high_impact	0.14	0.8	74.33	11.7	0.62	P	0.98	polymorphism	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9838	9838	G	C	MI.7982	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	632	211	G	A	gGc/gCc	9.15	1	0	probably_damaging	1	neutral	0.48	neutral	-0.36	deleterious	-7.88	deleterious	-5.71	high_impact	4.43	0.64	neutral	0.28	neutral	3.19	22.70	deleterious	0.03	0.35	0.46	neutral	0.75	disease	0.69	disease	0.68	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	0.17	medium_impact	2.79	high_impact	0.31	0.8	74.33	11.7	0.52	P	0.30	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9838	9838	G	T	MI.7983	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	632	211	G	V	gGc/gTc	9.15	1	0	probably_damaging	1	neutral	0.54	neutral	-0.39	deleterious	-9.8	deleterious	-8.56	high_impact	4.43	0.52	damaging	0.14	damaging	3.89	23.50	deleterious	0.02	0.35	0.61	disease	0.92	disease	0.74	disease	0.79	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	0.23	medium_impact	2.79	high_impact	0.17	0.8	74.33	11.7	0.51	P	0.97	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9840	9840	T	C	MI.7984	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	634	212	S	P	Tca/Cca	-6.81	0	0	probably_damaging	1	neutral	0.2	neutral	2.51	neutral	-1.99	deleterious	-2.59	medium_impact	3.48	0.58	damaging	0.38	neutral	4.06	23.70	deleterious	0.06	0.35	0.44	neutral	0.92	disease	0.7	disease	0.79	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.83	deleterious	-3.78	low_impact	-0.15	medium_impact	1.94	medium_impact	0.25	0.8	19.92	24.09	0.35	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9840	9840	T	G	MI.7985	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	634	212	S	A	Tca/Gca	-6.81	0	0	probably_damaging	0.98	neutral	0.51	neutral	2.59	neutral	1.2	neutral	-1.4	low_impact	1.57	0.6	neutral	0.76	neutral	3.66	23.20	deleterious	0.27	0.45	0.15	neutral	0.58	disease	0.47	neutral	0.45	neutral	1	0.97	neutral	0.27	neutral	-2	neutral	0.62	deleterious	-2.51	low_impact	0.2	medium_impact	0.22	medium_impact	0.43	0.8	19.92	24.09	0.32	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9840	9840	T	A	MI.7986	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	634	212	S	T	Tca/Aca	-6.81	0	0	probably_damaging	0.96	neutral	0.4	neutral	2.68	neutral	1.3	neutral	2.2	neutral_impact	-0.57	0.69	neutral	0.9	neutral	1.22	11.83	neutral	0.32	0.5	0.15	neutral	0.08	neutral	0.26	neutral	0.23	neutral	5	0.96	neutral	0.22	neutral	-2	neutral	0.61	deleterious	-2.21	low_impact	0.09	medium_impact	-1.69	low_impact	0.41	0.8	19.92	24.09	0.39	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9841	9841	C	G	MI.7987	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	635	212	S	W	tCa/tGa	1.75	0.96	0	probably_damaging	1	neutral	0.19	neutral	2.5	neutral	-2.75	deleterious	-3.77	medium_impact	3.48	0.62	neutral	0.43	neutral	4.43	24.20	deleterious	0.06	0.35	0.67	disease	0.93	disease	0.63	disease	0.79	disease	6	1	deleterious	0.1	neutral	1	deleterious	0.84	deleterious	-3.78	low_impact	-0.17	medium_impact	1.94	medium_impact	0.12	0.8	19.92	24.09	0.42	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9841	9841	C	T	MI.7988	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	635	212	S	L	tCa/tTa	1.75	0.96	0	probably_damaging	1	neutral	0.66	neutral	2.81	neutral	2.45	deleterious	-2.82	low_impact	1.28	0.63	neutral	0.42	neutral	4.57	24.40	deleterious	0.09	0.4	0.11	neutral	0.85	disease	0.56	disease	0.7	disease	4	1	deleterious	0.33	neutral	-2	neutral	0.70	deleterious	-3.78	low_impact	0.36	medium_impact	-0.04	medium_impact	0.31	0.8	19.92	24.09	0.33	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9843	9843	A	C	MI.7989	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	637	213	T	P	Act/Cct	-13.75	0	0	possibly_damaging	0.48	neutral	0.12	neutral	2.5	neutral	-2.17	deleterious	-4	medium_impact	3.23	0.56	damaging	0.34	neutral	3.50	23.10	deleterious	0.05	0.35	0.45	neutral	0.86	disease	0.58	disease	0.75	disease	5	0.87	neutral	0.32	neutral	0	NA	0.66	deleterious	-0.84	medium_impact	-0.3	medium_impact	1.71	medium_impact	0.23	0.8	76.25	9.77	0.35	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8902	8902	G	C	MI.799	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	376	126	A	P	Gcc/Ccc	-0.1	0.7	0	possibly_damaging	0.83	deleterious	0.04	neutral	4.27	neutral	-2.55	deleterious	-3.6	high_impact	3.8	0.71	neutral	0.35	neutral	3.83	23.40	deleterious	0.15	0.65	0.8	disease	0.91	disease	0.72	disease	0.74	disease	5	0.98	neutral	0.11	neutral	5	deleterious	0.86	deleterious	-1.41	low_impact	-0.49	medium_impact	2.16	high_impact	0.73	0.9	50.44	8.66	0.36	N	0.95	polymorphism	0.85	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9843	9843	A	T	MI.7990	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	637	213	T	S	Act/Tct	-13.75	0	0	benign	0.06	neutral	0.46	neutral	2.53	neutral	-1.02	neutral	-1.69	neutral_impact	0.65	0.69	neutral	0.74	neutral	0.26	5.28	deleterious	0.37	0.5	0.22	neutral	0.34	neutral	0.3	neutral	0.45	neutral	1	0.49	neutral	0.7	deleterious	-6	neutral	0.18	neutral	0.29	medium_impact	0.15	medium_impact	-0.6	medium_impact	0.38	0.8	76.25	9.77	0.45	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9843	9843	A	G	MI.7991	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	637	213	T	A	Act/Gct	-13.75	0	0	benign	0.03	neutral	0.31	neutral	2.58	neutral	0.52	deleterious	-2.56	low_impact	1.12	0.73	neutral	0.66	neutral	1.66	14.19	neutral	0.26	0.45	0.15	neutral	0.5	disease	0.33	neutral	0.44	neutral	1	0.67	neutral	0.64	deleterious	-6	neutral	0.15	neutral	0.6	medium_impact	-0.01	medium_impact	-0.18	medium_impact	0.24	0.8	76.25	9.77	0.43	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9844	9844	C	A	MI.7992	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	638	213	T	N	aCt/aAt	-0.33	0	0	benign	0.39	neutral	0.18	neutral	2.5	neutral	-2.4	deleterious	-3.11	medium_impact	2.68	0.62	neutral	0.39	neutral	3.70	23.30	deleterious	0.27	0.45	0.39	neutral	0.71	disease	0.54	disease	0.68	disease	4	0.79	neutral	0.4	neutral	-3	neutral	0.41	neutral	-0.68	medium_impact	-0.18	medium_impact	1.22	medium_impact	0.38	0.8	76.25	9.77	0.35	N	0.87	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9844	9844	C	G	MI.7993	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	638	213	T	S	aCt/aGt	-0.33	0	0	benign	0.06	neutral	0.46	neutral	2.53	neutral	-1.02	neutral	-1.69	neutral_impact	0.65	0.69	neutral	0.74	neutral	0.40	6.59	deleterious	0.37	0.5	0.22	neutral	0.34	neutral	0.3	neutral	0.45	neutral	1	0.49	neutral	0.7	deleterious	-6	neutral	0.18	neutral	0.29	medium_impact	0.15	medium_impact	-0.6	medium_impact	0.38	0.8	76.25	9.77	0.41	N	0.34	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9844	9844	C	T	MI.7994	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	638	213	T	I	aCt/aTt	-0.33	0	0	benign	0.18	neutral	0.47	neutral	2.77	neutral	1.97	deleterious	-3.29	neutral_impact	-0.48	0.68	neutral	0.68	neutral	1.14	11.42	neutral	0.12	0.4	0.12	neutral	0.4	neutral	0.3	neutral	0.44	neutral	1	0.44	neutral	0.65	deleterious	-6	neutral	0.31	neutral	-0.23	medium_impact	0.16	medium_impact	-1.61	low_impact	0.49	0.8	76.25	9.77	0.32	N	0.85	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9846	9846	T	A	MI.7995	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	640	214	F	I	Ttc/Atc	-7.74	0	0	probably_damaging	0.97	neutral	0.55	neutral	2.09	neutral	-0.49	deleterious	-5.7	medium_impact	3	0.69	neutral	0.02	damaging	4.57	24.40	deleterious	0.16	0.45	0.23	neutral	0.88	disease	0.63	disease	0.71	disease	4	0.96	neutral	0.29	neutral	1	deleterious	0.75	deleterious	-2.34	low_impact	0.24	medium_impact	1.51	medium_impact	0.30	0.8	74.33	11.72	0.24	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9846	9846	T	C	MI.7996	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	640	214	F	L	Ttc/Ctc	-7.74	0	0	probably_damaging	0.95	neutral	0.98	neutral	2.18	neutral	-0.13	deleterious	-5.7	medium_impact	2.37	0.65	neutral	0.03	damaging	4.23	23.90	deleterious	0.17	0.45	0.1	neutral	0.85	disease	0.6	disease	0.66	disease	3	0.94	neutral	0.52	deleterious	1	deleterious	0.71	deleterious	-2.11	low_impact	1.16	medium_impact	0.94	medium_impact	0.52	0.8	74.33	11.72	0.17	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9846	9846	T	G	MI.7997	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	640	214	F	V	Ttc/Gtc	-7.74	0	0	probably_damaging	0.98	neutral	0.34	neutral	2.1	neutral	-0.54	deleterious	-6.65	high_impact	3.71	0.66	neutral	0.02	damaging	4.28	24.00	deleterious	0.13	0.4	0.17	neutral	0.92	disease	0.64	disease	0.72	disease	4	0.99	deleterious	0.18	neutral	2	deleterious	0.75	deleterious	-2.51	low_impact	0.03	medium_impact	2.14	high_impact	0.35	0.8	74.33	11.72	0.29	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9847	9847	T	A	MI.7998	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	641	214	F	Y	tTc/tAc	5.68	1	0	probably_damaging	0.95	neutral	0.38	neutral	2.07	neutral	-2.39	deleterious	-2.85	medium_impact	3.1	0.69	neutral	0.03	damaging	4.36	24.10	deleterious	0.23	0.45	0.28	neutral	0.87	disease	0.65	disease	0.71	disease	4	0.95	neutral	0.22	neutral	1	deleterious	0.75	deleterious	-2.11	low_impact	0.07	medium_impact	1.6	medium_impact	0.44	0.8	74.33	11.72	0.49	N	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9847	9847	T	C	MI.7999	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	641	214	F	S	tTc/tCc	5.68	1	0	probably_damaging	0.99	neutral	0.35	neutral	2.05	neutral	-2.09	deleterious	-7.6	high_impact	3.55	0.58	damaging	0.03	damaging	4.35	24.10	deleterious	0.06	0.35	0.37	neutral	0.89	disease	0.62	disease	0.71	disease	4	0.99	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-2.81	low_impact	0.04	medium_impact	2	medium_impact	0.30	0.8	74.33	11.72	0.42	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8530	8530	A	C	MI.8	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	4	2	N	H	Aac/Cac	7.3	1	0	probably_damaging	0.99	deleterious	0.03	neutral	4.61	neutral	-1.76	deleterious	-3.06	medium_impact	2.6	0.89	neutral	0.39	neutral	4.07	23.70	deleterious	0.65	0.7	0.71	disease	0.28	neutral	0.14	neutral	0.59	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.69	deleterious	-2.65	low_impact	-0.56	medium_impact	1.13	medium_impact	0.30	0.9	41.59	7.23	0.62	P	0.98	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8561	8561	C	A	MI.80	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	35	12	P	H	cCc/cAc	7.3	1	0	probably_damaging	1	neutral	0.1	neutral	4.6	neutral	-1.03	deleterious	-7.84	medium_impact	3.02	0.64	neutral	0.07	damaging	3.80	23.40	deleterious	0.38	0.65	0.7	disease	0.87	disease	0.74	disease	0.81	disease	6	1	deleterious	0.05	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	-0.25	medium_impact	1.49	medium_impact	0.62	0.9	50	8.94	0.5	P	0.67	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8902	8902	G	A	MI.800	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	376	126	A	T	Gcc/Acc	-0.1	0.7	0	benign	0.03	neutral	0.06	neutral	4.32	neutral	-0.9	deleterious	-2.86	medium_impact	2.44	0.85	neutral	0.58	neutral	4.25	23.90	deleterious	0.5	0.65	0.55	disease	0.72	disease	0.48	neutral	0.42	neutral	2	0.94	neutral	0.52	deleterious	-3	neutral	0.26	neutral	0.68	medium_impact	-0.38	medium_impact	0.99	medium_impact	0.80	0.9	50.44	8.66	0.33	N	0.54	polymorphism	0.95	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9847	9847	T	G	MI.8000	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	641	214	F	C	tTc/tGc	5.68	1	0	probably_damaging	1	neutral	0.09	neutral	2	deleterious	-3.55	deleterious	-7.6	high_impact	3.83	0.7	neutral	0.02	damaging	4.21	23.90	deleterious	0.07	0.35	0.56	disease	0.91	disease	0.62	disease	0.71	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.38	medium_impact	2.25	high_impact	0.19	0.8	74.33	11.72	0.46	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9848	9848	C	G	MI.8001	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	642	214	F	L	ttC/ttG	5.68	1	0	probably_damaging	0.95	neutral	0.98	neutral	2.18	neutral	-0.13	deleterious	-5.7	medium_impact	2.37	0.65	neutral	0.03	damaging	4.54	24.30	deleterious	0.17	0.45	0.1	neutral	0.85	disease	0.6	disease	0.66	disease	3	0.94	neutral	0.52	deleterious	1	deleterious	0.71	deleterious	-2.11	low_impact	1.16	medium_impact	0.94	medium_impact	0.52	0.8	74.33	11.72	0.36	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9848	9848	C	A	MI.8002	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	642	214	F	L	ttC/ttA	5.68	1	0	probably_damaging	0.95	neutral	0.98	neutral	2.18	neutral	-0.13	deleterious	-5.7	medium_impact	2.37	0.65	neutral	0.03	damaging	4.87	24.90	deleterious	0.17	0.45	0.1	neutral	0.85	disease	0.6	disease	0.66	disease	3	0.94	neutral	0.52	deleterious	1	deleterious	0.71	deleterious	-2.11	low_impact	1.16	medium_impact	0.94	medium_impact	0.52	0.8	74.33	11.72	0.36	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9849	9849	C	T	MI.8003	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	643	215	L	F	Ctc/Ttc	-1.72	0	0	probably_damaging	0.99	neutral	0.67	neutral	1.7	deleterious	-3.27	deleterious	-3.74	medium_impact	2.56	0.55	damaging	0.02	damaging	4.11	23.80	deleterious	0.12	0.4	0.45	neutral	0.82	disease	0.62	disease	0.69	disease	4	0.99	deleterious	0.34	neutral	1	deleterious	0.81	deleterious	-2.81	low_impact	0.37	medium_impact	1.11	medium_impact	0.38	0.8	74.33	11.66	0.18	N	0.95	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9849	9849	C	A	MI.8004	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	643	215	L	I	Ctc/Atc	-1.72	0	0	probably_damaging	0.98	neutral	0.25	neutral	1.77	neutral	-2.16	neutral	-1.78	low_impact	1.6	0.46	damaging	0.07	damaging	4.25	23.90	deleterious	0.24	0.45	0.18	neutral	0.7	disease	0.39	neutral	0.5	neutral	0	0.99	deleterious	0.14	neutral	-2	neutral	0.71	deleterious	-2.51	low_impact	-0.08	medium_impact	0.25	medium_impact	0.42	0.8	74.33	11.66	0.31	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9849	9849	C	G	MI.8005	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	643	215	L	V	Ctc/Gtc	-1.72	0	0	probably_damaging	0.95	neutral	0.46	neutral	1.78	neutral	-2.53	deleterious	-2.73	high_impact	4.19	0.52	damaging	0.01	damaging	3.58	23.20	deleterious	0.15	0.4	0.27	neutral	0.78	disease	0.63	disease	0.68	disease	4	0.95	neutral	0.26	neutral	2	deleterious	0.73	deleterious	-2.11	low_impact	0.15	medium_impact	2.57	high_impact	0.46	0.8	74.33	11.66	0.31	N	0.81	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9850	9850	T	A	MI.8006	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	644	215	L	H	cTc/cAc	0.13	0.01	0	probably_damaging	1	neutral	0.21	neutral	1.67	deleterious	-5.54	deleterious	-6.59	high_impact	4.54	0.55	damaging	0.02	damaging	4.27	24.00	deleterious	0.04	0.35	0.58	disease	0.88	disease	0.71	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.14	medium_impact	2.89	high_impact	0.24	0.8	74.33	11.66	0.41	N	0.97	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9850	9850	T	C	MI.8007	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	644	215	L	P	cTc/cCc	0.13	0.01	0	probably_damaging	1	neutral	0.05	neutral	1.67	deleterious	-5.59	deleterious	-6.6	high_impact	3.98	0.54	damaging	0.03	damaging	4.05	23.70	deleterious	0.02	0.35	0.6	disease	0.88	disease	0.73	disease	0.78	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.54	medium_impact	2.38	high_impact	0.39	0.8	74.33	11.66	0.31	N	0.99	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9850	9850	T	G	MI.8008	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	644	215	L	R	cTc/cGc	0.13	0.01	0	probably_damaging	1	neutral	0.25	neutral	1.69	deleterious	-4.99	deleterious	-5.67	high_impact	4.54	0.66	neutral	0.02	damaging	4.33	24.00	deleterious	0.02	0.35	0.45	neutral	0.93	disease	0.73	disease	0.83	disease	7	1	deleterious	0.13	neutral	2	deleterious	0.87	deleterious	-3.78	low_impact	-0.08	medium_impact	2.89	high_impact	0.12	0.8	74.33	11.66	0.42	N	0.99	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9852	9852	A	G	MI.8009	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	646	216	T	A	Act/Gct	-13.29	0	0	benign	0	neutral	0.31	neutral	2.66	neutral	1.06	neutral	-0.5	neutral_impact	-0.44	0.73	neutral	0.85	neutral	-0.50	0.22	neutral	0.25	0.45	0.12	neutral	0.17	neutral	0.24	neutral	0.26	neutral	5	0.69	neutral	0.66	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	-0.01	medium_impact	-1.58	low_impact	0.34	0.8	19.92	32.03	0.45	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8903	8903	C	G	MI.801	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	377	126	A	G	gCc/gGc	4.29	0.99	0	possibly_damaging	0.47	neutral	0.47	neutral	4.32	neutral	-1	neutral	-0.45	neutral_impact	0.48	0.77	neutral	0.59	neutral	1.61	13.91	neutral	0.35	0.65	0.33	neutral	0.16	neutral	0.26	neutral	0.27	neutral	5	0.5	neutral	0.5	deleterious	-3	neutral	0.47	deleterious	-0.71	medium_impact	0.26	medium_impact	-0.69	medium_impact	0.81	0.9	50.44	8.66	0.5	N	0.68	polymorphism	0.85	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9852	9852	A	T	MI.8010	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	646	216	T	S	Act/Tct	-13.29	0	0	benign	0	neutral	0.28	neutral	2.56	neutral	-0.72	neutral	-0.91	neutral_impact	0.16	0.73	neutral	0.81	neutral	0.20	4.70	deleterious	0.42	0.55	0.18	neutral	0.25	neutral	0.22	neutral	0.42	neutral	2	0.72	neutral	0.64	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	-0.04	medium_impact	-1.04	low_impact	0.58	0.8	19.92	32.03	0.55	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9852	9852	A	C	MI.8011	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	646	216	T	P	Act/Cct	-13.29	0	0	benign	0.15	deleterious	0.04	neutral	2.51	neutral	-2.73	neutral	-2.32	medium_impact	2.6	0.58	damaging	0.31	neutral	1.88	15.47	deleterious	0.05	0.35	0.43	neutral	0.78	disease	0.49	neutral	0.65	disease	3	0.96	neutral	0.45	neutral	1	deleterious	0.31	neutral	-0.14	medium_impact	-0.6	medium_impact	1.15	medium_impact	0.33	0.8	19.92	32.03	0.36	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9853	9853	C	A	MI.8012	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	647	216	T	N	aCt/aAt	-1.95	0	0	benign	0.05	neutral	0.16	neutral	2.51	neutral	-2.36	neutral	-2.06	medium_impact	2.25	0.7	neutral	0.54	neutral	1.83	15.19	deleterious	0.24	0.45	0.34	neutral	0.52	disease	0.36	neutral	0.48	neutral	1	0.83	neutral	0.56	deleterious	-3	neutral	0.16	neutral	0.37	medium_impact	-0.22	medium_impact	0.83	medium_impact	0.54	0.8	19.92	32.03	0.46	N	0.56	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9853	9853	C	G	MI.8013	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	647	216	T	S	aCt/aGt	-1.95	0	0	benign	0	neutral	0.28	neutral	2.56	neutral	-0.72	neutral	-0.91	neutral_impact	0.16	0.73	neutral	0.81	neutral	0.40	6.59	deleterious	0.42	0.55	0.18	neutral	0.25	neutral	0.22	neutral	0.42	neutral	2	0.72	neutral	0.64	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	-0.04	medium_impact	-1.04	low_impact	0.58	0.8	19.92	32.03	0.5	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9853	9853	C	T	MI.8014	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	647	216	T	I	aCt/aTt	-1.95	0	0	benign	0	neutral	0.24	neutral	2.64	neutral	0.76	neutral	1.14	neutral_impact	-0.48	0.78	neutral	0.98	neutral	-0.29	0.69	neutral	0.11	0.4	0.11	neutral	0.33	neutral	0.21	neutral	0.43	neutral	2	0.76	neutral	0.62	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	-0.09	medium_impact	-1.61	low_impact	0.58	0.8	19.92	32.03	0.37	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9855	9855	A	C	MI.8015	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	649	217	I	L	Atc/Ctc	-9.36	0	0	benign	0.01	neutral	1	neutral	2.25	neutral	-0.56	neutral	-1.6	low_impact	1.72	0.68	neutral	0.43	neutral	2.05	16.54	deleterious	0.19	0.45	0.15	neutral	0.59	disease	0.53	disease	0.54	disease	1	0.01	neutral	1	deleterious	-6	neutral	0.14	neutral	1.07	medium_impact	1.9	high_impact	0.36	medium_impact	0.43	0.8	22.99	32.68	0.29	N	0.16	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9855	9855	A	G	MI.8016	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	649	217	I	V	Atc/Gtc	-9.36	0	0	benign	0	neutral	0.59	neutral	2.58	neutral	1.16	neutral	0.4	neutral_impact	-0.7	0.74	neutral	0.99	neutral	-1.44	0.00	neutral	0.38	0.5	0.11	neutral	0.06	neutral	0.27	neutral	0.19	neutral	6	0.41	neutral	0.8	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	0.28	medium_impact	-1.81	low_impact	0.37	0.8	22.99	32.68	0.34	N	0.00	polymorphism	1	0.01	rs201552272	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	9855	9855	A	T	MI.8017	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	649	217	I	F	Atc/Ttc	-9.36	0	0	benign	0.16	neutral	0.63	neutral	2.15	neutral	-1.71	deleterious	-3.32	low_impact	1.6	0.62	neutral	0.42	neutral	3.63	23.20	deleterious	0.16	0.45	0.24	neutral	0.77	disease	0.51	disease	0.54	disease	1	0.25	neutral	0.74	deleterious	-6	neutral	0.29	neutral	-0.17	medium_impact	0.32	medium_impact	0.25	medium_impact	0.41	0.8	22.99	32.68	0.32	N	0.40	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9856	9856	T	A	MI.8018	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	650	217	I	N	aTc/aAc	-0.33	0	0	benign	0.12	neutral	0.08	neutral	2.1	deleterious	-3.45	deleterious	-4.9	medium_impact	3.44	0.64	neutral	0.36	neutral	2.94	22.00	deleterious	0.09	0.35	0.44	neutral	0.82	disease	0.59	disease	0.75	disease	5	0.91	neutral	0.48	deleterious	-3	neutral	0.31	neutral	-0.03	medium_impact	-0.41	medium_impact	1.9	medium_impact	0.19	0.8	22.99	32.68	0.4	N	0.50	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9856	9856	T	C	MI.8019	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	650	217	I	T	aTc/aCc	-0.33	0	0	benign	0	neutral	0.12	neutral	2.15	neutral	-1.78	neutral	-2.24	low_impact	1.19	0.75	neutral	0.93	neutral	0.31	5.83	deleterious	0.12	0.4	0.19	neutral	0.49	neutral	0.39	neutral	0.45	neutral	1	0.88	neutral	0.56	deleterious	-6	neutral	0.14	neutral	2.05	high_impact	-0.3	medium_impact	-0.12	medium_impact	0.20	0.8	22.99	32.68	0.47	N	0.23	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8903	8903	C	T	MI.802	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	377	126	A	V	gCc/gTc	4.29	0.99	0	benign	0.39	neutral	0.12	neutral	4.28	neutral	-2.11	deleterious	-3.31	medium_impact	3.1	0.8	neutral	0.53	neutral	4.47	24.20	deleterious	0.34	0.65	0.58	disease	0.77	disease	0.6	disease	0.63	disease	3	0.86	neutral	0.37	neutral	-3	neutral	0.56	deleterious	-0.57	medium_impact	-0.2	medium_impact	1.56	medium_impact	0.84	0.9	50.44	8.66	0.47	N	0.68	polymorphism	0.82	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9856	9856	T	G	MI.8020	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	650	217	I	S	aTc/aGc	-0.33	0	0	benign	0.07	neutral	0.25	neutral	2.12	neutral	-2.43	deleterious	-3.88	low_impact	1.85	0.63	neutral	0.43	neutral	2.57	19.90	deleterious	0.04	0.35	0.28	neutral	0.77	disease	0.56	disease	0.68	disease	4	0.72	neutral	0.59	deleterious	-6	neutral	0.21	neutral	0.22	medium_impact	-0.08	medium_impact	0.48	medium_impact	0.18	0.8	22.99	32.68	0.38	N	0.41	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9857	9857	C	A	MI.8021	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	651	217	I	M	atC/atA	2.44	0.1	0	benign	0.37	neutral	0.1	neutral	2.13	neutral	-2.33	neutral	-1.82	low_impact	1.71	0.68	neutral	0.7	neutral	3.52	23.10	deleterious	0.25	0.45	0.29	neutral	0.5	disease	0.49	neutral	0.47	neutral	1	0.88	neutral	0.37	neutral	-6	neutral	0.26	neutral	-0.64	medium_impact	-0.35	medium_impact	0.35	medium_impact	0.35	0.8	22.99	32.68	0.53	N	0.12	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9857	9857	C	G	MI.8022	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	651	217	I	M	atC/atG	2.44	0.1	0	benign	0.37	neutral	0.1	neutral	2.13	neutral	-2.33	neutral	-1.82	low_impact	1.71	0.68	neutral	0.7	neutral	3.16	22.60	deleterious	0.25	0.45	0.29	neutral	0.5	disease	0.49	neutral	0.47	neutral	1	0.88	neutral	0.37	neutral	-6	neutral	0.26	neutral	-0.64	medium_impact	-0.35	medium_impact	0.35	medium_impact	0.35	0.8	22.99	32.68	0.54	N	0.12	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9858	9858	T	C	MI.8023	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	652	218	C	R	Tgc/Cgc	-15.37	0	0	probably_damaging	1	neutral	0.49	neutral	2.5	neutral	-2.2	deleterious	-10.59	high_impact	3.58	0.72	neutral	0.03	damaging	3.58	23.20	deleterious	0.06	0.35	0.34	neutral	0.96	disease	0.73	disease	0.86	disease	7	1	deleterious	0.25	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	0.18	medium_impact	2.03	high_impact	0.07	0.8	73.56	11.78	0.3	N	0.94	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9858	9858	T	A	MI.8024	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	652	218	C	S	Tgc/Agc	-15.37	0	0	probably_damaging	1	neutral	0.41	neutral	2.53	neutral	-1.07	deleterious	-8.62	low_impact	1.53	0.48	damaging	0.07	damaging	3.60	23.20	deleterious	0.08	0.35	0.24	neutral	0.8	disease	0.42	neutral	0.51	disease	0	1	deleterious	0.21	neutral	-2	neutral	0.76	deleterious	-3.78	low_impact	0.1	medium_impact	0.19	medium_impact	0.41	0.8	73.56	11.78	0.32	N	0.86	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9858	9858	T	G	MI.8025	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	652	218	C	G	Tgc/Ggc	-15.37	0	0	probably_damaging	1	neutral	0.46	neutral	2.49	neutral	-1.76	deleterious	-10.56	medium_impact	2.65	0.53	damaging	0.05	damaging	3.39	23.00	deleterious	0.07	0.35	0.24	neutral	0.91	disease	0.48	neutral	0.51	disease	0	1	deleterious	0.23	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	0.15	medium_impact	1.19	medium_impact	0.26	0.8	73.56	11.78	0.28	N	0.95	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9859	9859	G	T	MI.8026	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	653	218	C	F	tGc/tTc	5.68	1	0	probably_damaging	1	neutral	0.84	neutral	2.5	neutral	-1.26	deleterious	-9.73	high_impact	3.78	0.62	neutral	0.03	damaging	4.04	23.70	deleterious	0.08	0.35	0.26	neutral	0.96	disease	0.63	disease	0.78	disease	6	1	deleterious	0.42	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	0.6	medium_impact	2.21	high_impact	0.27	0.8	73.56	11.78	0.4	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9859	9859	G	A	MI.8027	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	653	218	C	Y	tGc/tAc	5.68	1	0	probably_damaging	1	neutral	1	neutral	2.51	neutral	-1.34	deleterious	-9.72	high_impact	3.58	0.65	neutral	0.02	damaging	3.74	23.30	deleterious	0.07	0.35	0.21	neutral	0.95	disease	0.65	disease	0.78	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.81	deleterious	-3.78	low_impact	1.9	high_impact	2.03	high_impact	0.41	0.8	73.56	11.78	0.37	N	1.00	polymorphism	1	0.16	.	.	.	.	.	.	COSM1138445	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9859	9859	G	C	MI.8028	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	653	218	C	S	tGc/tCc	5.68	1	0	probably_damaging	1	neutral	0.41	neutral	2.53	neutral	-1.07	deleterious	-8.62	low_impact	1.53	0.48	damaging	0.07	damaging	3.31	22.90	deleterious	0.08	0.35	0.24	neutral	0.8	disease	0.42	neutral	0.51	disease	0	1	deleterious	0.21	neutral	-2	neutral	0.76	deleterious	-3.78	low_impact	0.1	medium_impact	0.19	medium_impact	0.41	0.8	73.56	11.78	0.4	N	0.86	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9860	9860	C	G	MI.8029	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	654	218	C	W	tgC/tgG	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	2.47	deleterious	-3.59	deleterious	-9.69	high_impact	4.12	0.69	neutral	0.03	damaging	4.43	24.20	deleterious	0.05	0.35	0.58	disease	0.96	disease	0.69	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.18	medium_impact	2.51	high_impact	0.27	0.8	73.56	11.78	0.47	N	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8903	8903	C	A	MI.803	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	377	126	A	D	gCc/gAc	4.29	0.99	0	possibly_damaging	0.77	deleterious	0.01	neutral	4.33	neutral	-0.73	deleterious	-3.84	medium_impact	3.44	0.78	neutral	0.42	neutral	4.66	24.50	deleterious	0.19	0.65	0.68	disease	0.91	disease	0.65	disease	0.74	disease	5	0.99	deleterious	0.12	neutral	4	deleterious	0.79	deleterious	-1.25	low_impact	-0.84	medium_impact	1.85	medium_impact	0.63	0.9	50.44	8.66	0.47	N	1.00	polymorphism	0.52	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9860	9860	C	A	MI.8030	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	654	218	C	W	tgC/tgA	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	2.47	deleterious	-3.59	deleterious	-9.69	high_impact	4.12	0.69	neutral	0.03	damaging	4.74	24.60	deleterious	0.05	0.35	0.58	disease	0.96	disease	0.69	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.18	medium_impact	2.51	high_impact	0.27	0.8	73.56	11.78	0.48	N	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9861	9861	T	C	MI.8031	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	655	219	F	L	Ttc/Ctc	-0.33	0	0	benign	0	neutral	1	neutral	2.81	neutral	1.43	neutral	2.72	neutral_impact	-1.69	0.69	neutral	0.95	neutral	-0.44	0.31	neutral	0.21	0.45	0.1	neutral	0.14	neutral	0.17	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	1.9	high_impact	-2.7	low_impact	0.69	0.85	21.46	37.53	0.48	N	0.00	polymorphism	1	0.01	rs878853060	Likely_benign	not_provided	237218	MedGen:CN517202	.	.	CPD	17.06	T9861C	AD	+	-	Reported	1	N	P	N,P	neutral
chrM	9861	9861	T	G	MI.8032	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	655	219	F	V	Ttc/Gtc	-0.33	0	0	benign	0.05	neutral	0.27	neutral	2.56	neutral	-0.17	neutral	0.19	low_impact	1.6	0.66	neutral	0.58	neutral	2.40	18.81	deleterious	0.11	0.4	0.15	neutral	0.74	disease	0.48	neutral	0.55	disease	1	0.71	neutral	0.61	deleterious	-6	neutral	0.15	neutral	0.37	medium_impact	-0.06	medium_impact	0.25	medium_impact	0.26	0.8	21.46	37.53	0.41	N	0.35	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9861	9861	T	A	MI.8033	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	655	219	F	I	Ttc/Atc	-0.33	0	0	benign	0.01	neutral	0.5	neutral	2.6	neutral	-0.09	neutral	1.09	low_impact	1.32	0.66	neutral	0.63	neutral	2.62	20.30	deleterious	0.14	0.4	0.15	neutral	0.67	disease	0.35	neutral	0.51	disease	0	0.48	neutral	0.75	deleterious	-6	neutral	0.15	neutral	1.07	medium_impact	0.19	medium_impact	0	medium_impact	0.35	0.8	21.46	37.53	0.34	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9862	9862	T	A	MI.8034	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	656	219	F	Y	tTc/tAc	-0.33	0	0	benign	0.09	neutral	0.54	neutral	2.53	neutral	-0.93	neutral	-1.11	low_impact	0.84	0.71	neutral	0.66	neutral	2.66	20.50	deleterious	0.19	0.45	0.27	neutral	0.57	disease	0.35	neutral	0.47	neutral	1	0.38	neutral	0.73	deleterious	-6	neutral	0.20	neutral	0.11	medium_impact	0.23	medium_impact	-0.43	medium_impact	0.58	0.8	21.46	37.53	0.31	N	0.42	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9862	9862	T	C	MI.8035	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	656	219	F	S	tTc/tCc	-0.33	0	0	benign	0.18	neutral	0.31	neutral	2.53	neutral	-1.56	neutral	-2.41	medium_impact	1.94	0.64	neutral	0.48	neutral	2.81	21.40	deleterious	0.04	0.35	0.27	neutral	0.65	disease	0.47	neutral	0.52	disease	0	0.63	neutral	0.57	deleterious	-3	neutral	0.31	neutral	-0.23	medium_impact	-0.01	medium_impact	0.56	medium_impact	0.17	0.8	21.46	37.53	0.41	N	0.68	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9862	9862	T	G	MI.8036	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	656	219	F	C	tTc/tGc	-0.33	0	0	possibly_damaging	0.67	neutral	0.5	neutral	2.48	neutral	-2.92	neutral	-1.58	low_impact	1.25	0.63	neutral	0.48	neutral	4.16	23.80	deleterious	0.05	0.35	0.47	neutral	0.79	disease	0.37	neutral	0.65	disease	3	0.64	neutral	0.42	neutral	-3	neutral	0.60	deleterious	-1.17	low_impact	0.19	medium_impact	-0.06	medium_impact	0.15	0.8	21.46	37.53	0.28	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9863	9863	C	G	MI.8037	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	657	219	F	L	ttC/ttG	7.53	0.96	0	benign	0	neutral	1	neutral	2.81	neutral	1.43	neutral	2.72	neutral_impact	-1.69	0.69	neutral	0.95	neutral	-0.20	1.07	neutral	0.21	0.45	0.1	neutral	0.14	neutral	0.17	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	1.9	high_impact	-2.7	low_impact	0.69	0.85	21.46	37.53	0.54	P	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9863	9863	C	A	MI.8038	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	657	219	F	L	ttC/ttA	7.53	0.96	0	benign	0	neutral	1	neutral	2.81	neutral	1.43	neutral	2.72	neutral_impact	-1.69	0.69	neutral	0.95	neutral	0.16	4.22	deleterious	0.21	0.45	0.1	neutral	0.14	neutral	0.17	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	1.9	high_impact	-2.7	low_impact	0.69	0.85	21.46	37.53	0.55	P	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9864	9864	A	C	MI.8039	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	658	220	I	L	Atc/Ctc	-11.21	0	0	benign	0.01	neutral	1	neutral	2.39	neutral	0.03	neutral	0.18	neutral_impact	-0.74	0.77	neutral	0.95	neutral	-0.67	0.09	neutral	0.17	0.45	0.14	neutral	0.16	neutral	0.11	neutral	0.28	neutral	5	0.01	neutral	1	deleterious	-6	neutral	0.09	neutral	1.07	medium_impact	1.9	high_impact	-1.85	low_impact	0.28	0.8	18.01	34.58	0.4	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8905	8905	C	A	MI.804	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	379	127	H	N	Cac/Aac	-6.35	0	0.01	probably_damaging	0.98	deleterious	0.02	neutral	3.76	neutral	-2.48	deleterious	-6.47	high_impact	3.86	0.56	damaging	0.4	neutral	3.96	23.60	deleterious	0.59	0.7	0.46	neutral	0.83	disease	0.77	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.78	deleterious	-2.36	low_impact	-0.66	medium_impact	2.21	high_impact	0.50	0.9	50.44	8.73	0.41	N	0.98	disease_causing	0.65	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9864	9864	A	G	MI.8040	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	658	220	I	V	Atc/Gtc	-11.21	0	0	benign	0	neutral	0.29	neutral	2.34	neutral	-0.25	neutral	-0.49	neutral_impact	-0.34	0.77	neutral	0.83	neutral	0.15	4.10	deleterious	0.3	0.45	0.19	neutral	0.18	neutral	0.16	neutral	0.31	neutral	4	0.71	neutral	0.65	deleterious	-6	neutral	0.09	neutral	2.05	high_impact	-0.03	medium_impact	-1.49	low_impact	0.32	0.8	18.01	34.58	0.52	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9864	9864	A	T	MI.8041	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	658	220	I	F	Atc/Ttc	-11.21	0	0	benign	0.11	neutral	0.41	neutral	2.25	neutral	-1.27	neutral	-1.6	neutral_impact	-0.58	0.79	neutral	0.97	neutral	0.78	9.35	deleterious	0.14	0.4	0.23	neutral	0.39	neutral	0.13	neutral	0.44	neutral	1	0.53	neutral	0.65	deleterious	-6	neutral	0.15	neutral	0.01	medium_impact	0.1	medium_impact	-1.7	low_impact	0.32	0.8	18.01	34.58	0.45	N	0.14	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9865	9865	T	C	MI.8042	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	659	220	I	T	aTc/aCc	-7.51	0	0	benign	0	neutral	0.19	neutral	2.24	neutral	-1.79	deleterious	-2.6	low_impact	1.58	0.69	neutral	0.74	neutral	1.60	13.85	neutral	0.12	0.4	0.29	neutral	0.39	neutral	0.34	neutral	0.45	neutral	1	0.81	neutral	0.6	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	-0.17	medium_impact	0.23	medium_impact	0.19	0.8	18.01	34.58	0.5	N	0.34	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9865	9865	T	A	MI.8043	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	659	220	I	N	aTc/aAc	-7.51	0	0	benign	0.05	neutral	0.15	neutral	2.2	deleterious	-3.38	deleterious	-4.12	low_impact	1.66	0.71	neutral	0.47	neutral	2.78	21.30	deleterious	0.09	0.35	0.5	neutral	0.67	disease	0.46	neutral	0.48	neutral	0	0.84	neutral	0.55	deleterious	-6	neutral	0.22	neutral	0.37	medium_impact	-0.24	medium_impact	0.31	medium_impact	0.15	0.8	18.01	34.58	0.37	N	0.57	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9865	9865	T	G	MI.8044	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	659	220	I	S	aTc/aGc	-7.51	0	0	benign	0	neutral	0.23	neutral	2.23	neutral	-2.21	deleterious	-3.22	low_impact	1.51	0.69	neutral	0.6	neutral	2.48	19.35	deleterious	0.04	0.35	0.25	neutral	0.6	disease	0.36	neutral	0.48	neutral	0	0.77	neutral	0.62	deleterious	-6	neutral	0.15	neutral	2.05	high_impact	-0.11	medium_impact	0.17	medium_impact	0.15	0.8	18.01	34.58	0.46	N	0.37	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9866	9866	C	G	MI.8045	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	660	220	I	M	atC/atG	3.83	0.39	0	benign	0.27	neutral	0.12	neutral	2.22	neutral	-2.08	neutral	-0.33	neutral_impact	0.21	0.76	neutral	0.96	neutral	0.55	7.83	deleterious	0.19	0.45	0.34	neutral	0.21	neutral	0.15	neutral	0.37	neutral	3	0.86	neutral	0.43	neutral	-6	neutral	0.18	neutral	-0.45	medium_impact	-0.3	medium_impact	-0.99	medium_impact	0.36	0.8	18.01	34.58	0.5	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9866	9866	C	A	MI.8046	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	660	220	I	M	atC/atA	3.83	0.39	0	benign	0.27	neutral	0.12	neutral	2.22	neutral	-2.08	neutral	-0.33	neutral_impact	0.21	0.76	neutral	0.96	neutral	0.97	10.47	neutral	0.19	0.45	0.34	neutral	0.21	neutral	0.15	neutral	0.37	neutral	3	0.86	neutral	0.43	neutral	-6	neutral	0.18	neutral	-0.45	medium_impact	-0.3	medium_impact	-0.99	medium_impact	0.36	0.8	18.01	34.58	0.5	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9867	9867	C	T	MI.8047	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	661	221	R	C	Cgc/Tgc	-7.04	0	0	benign	0.01	neutral	0.18	neutral	1.72	deleterious	-6.32	deleterious	-7.41	high_impact	4.14	0.67	neutral	0.02	damaging	3.23	22.80	deleterious	0.09	0.4	0.8	disease	0.85	disease	0.75	disease	0.8	disease	6	0.82	neutral	0.59	deleterious	-2	neutral	0.31	neutral	1.07	medium_impact	-0.18	medium_impact	2.53	high_impact	0.89	0.9	72.8	11.99	0.32	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9867	9867	C	G	MI.8048	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	661	221	R	G	Cgc/Ggc	-7.04	0	0	benign	0.28	neutral	0.33	neutral	1.76	deleterious	-4.21	deleterious	-6.46	high_impact	4.35	0.64	neutral	0.01	damaging	4.16	23.80	deleterious	0.05	0.35	0.48	neutral	0.8	disease	0.74	disease	0.74	disease	5	0.6	neutral	0.53	deleterious	-2	neutral	0.52	deleterious	-0.47	medium_impact	0.02	medium_impact	2.72	high_impact	0.28	0.8	72.8	11.99	0.37	N	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9867	9867	C	A	MI.8049	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	661	221	R	S	Cgc/Agc	-7.04	0	0	benign	0.17	neutral	0.4	neutral	1.79	deleterious	-3.37	deleterious	-5.56	high_impact	4.14	0.67	neutral	0.01	damaging	4.39	24.10	deleterious	0.05	0.35	0.32	neutral	0.8	disease	0.69	disease	0.7	disease	4	0.52	neutral	0.62	deleterious	-2	neutral	0.49	deleterious	-0.2	medium_impact	0.09	medium_impact	2.53	high_impact	0.31	0.8	72.8	11.99	0.33	N	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8905	8905	C	G	MI.805	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	379	127	H	D	Cac/Gac	-6.35	0	0.01	probably_damaging	0.99	deleterious	0.03	neutral	3.75	neutral	-2.97	deleterious	-8.32	high_impact	4.06	0.67	neutral	0.39	neutral	3.90	23.50	deleterious	0.32	0.65	0.74	disease	0.83	disease	0.77	disease	0.72	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.82	deleterious	-2.65	low_impact	-0.56	medium_impact	2.38	high_impact	0.46	0.9	50.44	8.73	0.41	N	1.00	disease_causing	0.86	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9868	9868	G	C	MI.8050	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	662	221	R	P	cGc/cCc	7.3	1	0	possibly_damaging	0.69	neutral	0.2	neutral	1.74	deleterious	-4.89	deleterious	-6.49	high_impact	3.8	0.62	neutral	0.03	damaging	4.38	24.10	deleterious	0.03	0.35	0.57	disease	0.84	disease	0.82	disease	0.8	disease	6	0.83	neutral	0.26	neutral	1	deleterious	0.75	deleterious	-1.21	low_impact	-0.15	medium_impact	2.22	high_impact	0.24	0.8	72.8	11.99	0.56	P	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9868	9868	G	A	MI.8051	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	662	221	R	H	cGc/cAc	7.3	1	0	possibly_damaging	0.58	neutral	0.54	neutral	1.75	deleterious	-4.44	deleterious	-4.63	high_impact	4.14	0.63	neutral	0.02	damaging	4.50	24.30	deleterious	0.14	0.4	0.5	disease	0.8	disease	0.7	disease	0.72	disease	4	0.54	neutral	0.48	deleterious	1	deleterious	0.70	deleterious	-1.01	low_impact	0.23	medium_impact	2.53	high_impact	0.96	1	72.8	11.99	0.55	P	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9868	9868	G	T	MI.8052	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	662	221	R	L	cGc/cTc	7.3	1	0	benign	0.05	neutral	0.66	neutral	1.76	deleterious	-3.98	deleterious	-6.49	high_impact	3.89	0.64	neutral	0.02	damaging	2.87	21.70	deleterious	0.06	0.35	0.35	neutral	0.89	disease	0.7	disease	0.75	disease	5	0.27	neutral	0.81	deleterious	-2	neutral	0.33	neutral	0.37	medium_impact	0.36	medium_impact	2.3	high_impact	0.09	0.8	72.8	11.99	0.48	N	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9870	9870	C	G	MI.8053	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	664	222	Q	E	Caa/Gaa	-8.66	0	0	probably_damaging	0.91	neutral	0.27	neutral	2.58	neutral	-0.2	neutral	-1.42	low_impact	1.82	0.53	damaging	0.07	damaging	3.18	22.70	deleterious	0.34	0.5	0.22	neutral	0.47	neutral	0.41	neutral	0.49	neutral	0	0.93	neutral	0.18	neutral	-2	neutral	0.67	deleterious	-1.85	low_impact	-0.06	medium_impact	0.45	medium_impact	0.42	0.8	78.16	10.52	0.32	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9870	9870	C	A	MI.8054	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	664	222	Q	K	Caa/Aaa	-8.66	0	0	probably_damaging	0.96	neutral	0.29	neutral	2.58	neutral	-0.24	neutral	-1.9	low_impact	1.91	0.52	damaging	0.04	damaging	4.07	23.70	deleterious	0.21	0.45	0.21	neutral	0.62	disease	0.41	neutral	0.49	neutral	0	0.97	neutral	0.17	neutral	-2	neutral	0.69	deleterious	-2.21	low_impact	-0.03	medium_impact	0.53	medium_impact	0.40	0.8	78.16	10.52	0.29	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9871	9871	A	C	MI.8055	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	665	222	Q	P	cAa/cCa	4.52	1	0	probably_damaging	0.99	neutral	0.2	neutral	2.58	neutral	-0.34	deleterious	-3.15	medium_impact	2.71	0.46	damaging	0.05	damaging	3.47	23.00	deleterious	0.05	0.35	0.39	neutral	0.79	disease	0.53	disease	0.72	disease	4	0.99	deleterious	0.11	neutral	1	deleterious	0.80	deleterious	-2.81	low_impact	-0.15	medium_impact	1.25	medium_impact	0.28	0.8	78.16	10.52	0.43	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9871	9871	A	T	MI.8056	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	665	222	Q	L	cAa/cTa	4.52	1	0	probably_damaging	0.96	neutral	0.69	neutral	2.78	neutral	2.45	neutral	-2.32	neutral_impact	-0.42	0.61	neutral	0.31	neutral	2.55	19.78	deleterious	0.09	0.35	0.1	neutral	0.29	neutral	0.16	neutral	0.42	neutral	2	0.95	neutral	0.37	neutral	-2	neutral	0.65	deleterious	-2.21	low_impact	0.39	medium_impact	-1.56	low_impact	0.11	0.8	78.16	10.52	0.41	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9871	9871	A	G	MI.8057	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	665	222	Q	R	cAa/cGa	4.52	1	0	probably_damaging	0.98	neutral	0.38	neutral	2.58	neutral	-0.1	neutral	-1.67	medium_impact	2.71	0.48	damaging	0.05	damaging	3.62	23.20	deleterious	0.21	0.45	0.26	neutral	0.61	disease	0.44	neutral	0.5	disease	0	0.98	neutral	0.2	neutral	1	deleterious	0.72	deleterious	-2.51	low_impact	0.07	medium_impact	1.25	medium_impact	0.16	0.8	78.16	10.52	0.46	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9872	9872	A	C	MI.8058	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	666	222	Q	H	caA/caC	4.52	1	0	probably_damaging	0.99	neutral	0.54	neutral	2.59	neutral	0.07	neutral	-0.32	neutral_impact	-0.06	0.6	damaging	0.1	damaging	2.15	17.18	deleterious	0.21	0.45	0.32	neutral	0.23	neutral	0.18	neutral	0.44	neutral	1	0.99	deleterious	0.28	neutral	-2	neutral	0.70	deleterious	-2.81	low_impact	0.23	medium_impact	-1.24	low_impact	0.57	0.8	78.16	10.52	0.42	N	0.98	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9872	9872	A	T	MI.8059	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	666	222	Q	H	caA/caT	4.52	1	0	probably_damaging	0.99	neutral	0.54	neutral	2.59	neutral	0.07	neutral	-0.32	neutral_impact	-0.06	0.6	damaging	0.1	damaging	2.29	18.08	deleterious	0.21	0.45	0.32	neutral	0.23	neutral	0.18	neutral	0.44	neutral	1	0.99	deleterious	0.28	neutral	-2	neutral	0.70	deleterious	-2.81	low_impact	0.23	medium_impact	-1.24	low_impact	0.57	0.8	78.16	10.52	0.42	N	0.98	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8905	8905	C	T	MI.806	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	379	127	H	Y	Cac/Tac	-6.35	0	0.01	probably_damaging	0.98	neutral	0.13	neutral	3.84	neutral	-0.67	deleterious	-5.55	medium_impact	3.08	0.57	damaging	0.32	neutral	3.77	23.40	deleterious	0.59	0.7	0.75	disease	0.84	disease	0.78	disease	0.72	disease	4	0.99	deleterious	0.08	neutral	1	deleterious	0.83	deleterious	-2.36	low_impact	-0.18	medium_impact	1.54	medium_impact	0.37	0.9	50.44	8.73	0.33	N	1.00	disease_causing	0.69	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9873	9873	C	A	MI.8060	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	667	223	L	M	Cta/Ata	2.9	0.98	0	probably_damaging	1	neutral	0.23	neutral	2.19	neutral	-1.59	neutral	-0.27	neutral_impact	0.78	0.75	neutral	0.95	neutral	2.76	21.10	deleterious	0.29	0.45	0.19	neutral	0.12	neutral	0.12	neutral	0.29	neutral	4	1	deleterious	0.12	neutral	-2	neutral	0.62	deleterious	-3.78	low_impact	-0.11	medium_impact	-0.48	medium_impact	0.53	0.8	20.69	26.81	0.61	P	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9873	9873	C	G	MI.8061	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	667	223	L	V	Cta/Gta	2.9	0.98	0	probably_damaging	0.96	neutral	0.5	neutral	2.29	neutral	-0.91	neutral	-0.9	low_impact	1.7	0.79	neutral	0.93	neutral	2.09	16.81	deleterious	0.26	0.45	0.14	neutral	0.26	neutral	0.14	neutral	0.42	neutral	2	0.95	neutral	0.27	neutral	-2	neutral	0.60	deleterious	-2.21	low_impact	0.19	medium_impact	0.34	medium_impact	0.47	0.8	20.69	26.81	0.47	N	0.56	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9874	9874	T	C	MI.8062	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	668	223	L	P	cTa/cCa	-2.88	0	0	probably_damaging	1	neutral	0.2	neutral	2.13	deleterious	-4	deleterious	-4.1	medium_impact	3.08	0.58	damaging	0.04	damaging	4.11	23.80	deleterious	0.04	0.35	0.52	disease	0.76	disease	0.47	neutral	0.56	disease	1	1	deleterious	0.1	neutral	1	deleterious	0.81	deleterious	-3.78	low_impact	-0.15	medium_impact	1.58	medium_impact	0.14	0.8	20.69	26.81	0.26	N	0.90	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9874	9874	T	A	MI.8063	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	668	223	L	Q	cTa/cAa	-2.88	0	0	probably_damaging	1	neutral	0.29	neutral	2.15	deleterious	-3.02	deleterious	-3.1	medium_impact	2.33	0.74	neutral	0.2	damaging	4.32	24.00	deleterious	0.09	0.35	0.45	neutral	0.54	disease	0.3	neutral	0.48	neutral	0	1	deleterious	0.15	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	-0.03	medium_impact	0.91	medium_impact	0.15	0.8	20.69	26.81	0.34	N	0.92	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9874	9874	T	G	MI.8064	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	668	223	L	R	cTa/cGa	-2.88	0	0	probably_damaging	1	neutral	0.35	neutral	2.17	neutral	-1.63	deleterious	-3.43	low_impact	1.45	0.61	neutral	0.06	damaging	4.33	24.00	deleterious	0.06	0.35	0.34	neutral	0.72	disease	0.43	neutral	0.55	disease	1	1	deleterious	0.18	neutral	-2	neutral	0.75	deleterious	-3.78	low_impact	0.04	medium_impact	0.12	medium_impact	0.13	0.8	20.69	26.81	0.24	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9876	9876	A	G	MI.8065	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	670	224	M	V	Ata/Gta	-3.34	0	0	benign	0	neutral	0.5	neutral	2.34	neutral	0.96	neutral	-1.26	low_impact	0.87	0.78	neutral	0.72	neutral	-0.75	0.06	neutral	0.32	0.5	0.13	neutral	0.4	neutral	0.34	neutral	0.43	neutral	1	0.49	neutral	0.75	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.19	medium_impact	-0.4	medium_impact	0.26	0.8	24.52	40.54	0.31	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9876	9876	A	C	MI.8066	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	670	224	M	L	Ata/Cta	-3.34	0	0	benign	0	neutral	0.66	neutral	2.35	neutral	1.17	neutral	-0.62	neutral_impact	-0.8	0.78	neutral	0.9	neutral	-0.78	0.05	neutral	0.27	0.45	0.11	neutral	0.27	neutral	0.19	neutral	0.41	neutral	2	0.34	neutral	0.83	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.36	medium_impact	-1.9	low_impact	0.24	0.8	24.52	40.54	0.38	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9876	9876	A	T	MI.8067	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	670	224	M	L	Ata/Tta	-3.34	0	0	benign	0	neutral	0.66	neutral	2.35	neutral	1.17	neutral	-0.62	neutral_impact	-0.8	0.78	neutral	0.9	neutral	-0.67	0.08	neutral	0.27	0.45	0.11	neutral	0.27	neutral	0.19	neutral	0.41	neutral	2	0.34	neutral	0.83	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.36	medium_impact	-1.9	low_impact	0.24	0.8	24.52	40.54	0.38	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9877	9877	T	C	MI.8068	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	671	224	M	T	aTa/aCa	-0.1	0	0.01	benign	0.01	neutral	0.39	neutral	2.38	neutral	1.48	neutral	-1.05	neutral_impact	0.69	0.76	neutral	0.77	neutral	-0.42	0.34	neutral	0.22	0.45	0.11	neutral	0.37	neutral	0.38	neutral	0.43	neutral	1	0.6	neutral	0.69	deleterious	-6	neutral	0.11	neutral	1.07	medium_impact	0.08	medium_impact	-0.56	medium_impact	0.04	0.8	24.52	40.54	0.36	N	0.15	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9877	9877	T	A	MI.8069	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	671	224	M	K	aTa/aAa	-0.1	0	0.01	benign	0.01	neutral	0.3	neutral	2.44	neutral	2.62	neutral	-0.62	neutral_impact	-0.98	0.79	neutral	0.88	neutral	0.44	6.92	deleterious	0.13	0.4	0.2	neutral	0.36	neutral	0.31	neutral	0.44	neutral	1	0.69	neutral	0.65	deleterious	-6	neutral	0.13	neutral	1.07	medium_impact	-0.02	medium_impact	-2.06	low_impact	0.12	0.8	24.52	40.54	0.33	N	0.23	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8906	8906	A	G	MI.807	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	380	127	H	R	cAc/cGc	7.3	1	0	probably_damaging	0.99	deleterious	0.01	neutral	3.77	neutral	-1.97	deleterious	-7.39	high_impact	4.06	0.49	damaging	0.34	neutral	3.07	22.40	deleterious	0.59	0.7	0.61	disease	0.84	disease	0.76	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.65	low_impact	-0.84	medium_impact	2.38	high_impact	0.35	0.9	50.44	8.73	0.55	P	1.00	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9878	9878	A	C	MI.8070	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	672	224	M	I	atA/atC	0.13	0	0	benign	0	neutral	0.4	neutral	2.32	neutral	-0.15	neutral	-1.22	neutral_impact	0.66	0.78	neutral	0.56	neutral	-0.05	2.15	deleterious	0.25	0.45	0.21	neutral	0.44	neutral	0.32	neutral	0.47	neutral	1	0.59	neutral	0.7	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	0.09	medium_impact	-0.59	medium_impact	0.34	0.8	24.52	40.54	0.34	N	0.06	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9878	9878	A	T	MI.8071	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	672	224	M	I	atA/atT	0.13	0	0	benign	0	neutral	0.4	neutral	2.32	neutral	-0.15	neutral	-1.22	neutral_impact	0.66	0.78	neutral	0.56	neutral	0.02	2.73	deleterious	0.25	0.45	0.21	neutral	0.44	neutral	0.32	neutral	0.47	neutral	1	0.59	neutral	0.7	deleterious	-6	neutral	0.13	neutral	2.05	high_impact	0.09	medium_impact	-0.59	medium_impact	0.34	0.8	24.52	40.54	0.35	N	0.06	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9879	9879	T	C	MI.8072	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	673	225	F	L	Ttt/Ctt	-1.72	0	0	benign	0.14	neutral	0.59	neutral	2.61	neutral	0.3	deleterious	-2.56	low_impact	1.42	0.74	neutral	0.69	neutral	1.40	12.80	neutral	0.19	0.45	0.16	neutral	0.4	neutral	0.3	neutral	0.45	neutral	1	0.3	neutral	0.73	deleterious	-6	neutral	0.23	neutral	-0.1	medium_impact	0.28	medium_impact	0.09	medium_impact	0.33	0.8	20.31	24.77	0.32	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9879	9879	T	G	MI.8073	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	673	225	F	V	Ttt/Gtt	-1.72	0	0	benign	0.37	neutral	0.31	neutral	2.58	neutral	0.27	deleterious	-2.99	medium_impact	2.57	0.71	neutral	0.52	neutral	3.74	23.30	deleterious	0.18	0.45	0.17	neutral	0.62	disease	0.32	neutral	0.5	disease	0	0.63	neutral	0.47	deleterious	-3	neutral	0.35	neutral	-0.64	medium_impact	-0.01	medium_impact	1.12	medium_impact	0.25	0.8	20.31	24.77	0.43	N	0.76	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9879	9879	T	A	MI.8074	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	673	225	F	I	Ttt/Att	-1.72	0	0	benign	0.21	neutral	0.3	neutral	2.57	neutral	0.06	deleterious	-2.65	medium_impact	2.37	0.73	neutral	0.59	neutral	4.06	23.70	deleterious	0.18	0.45	0.21	neutral	0.55	disease	0.32	neutral	0.5	disease	0	0.64	neutral	0.55	deleterious	-3	neutral	0.36	neutral	-0.31	medium_impact	-0.02	medium_impact	0.94	medium_impact	0.27	0.8	20.31	24.77	0.44	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9880	9880	T	G	MI.8075	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	674	225	F	C	tTt/tGt	3.14	0.16	0	probably_damaging	0.93	neutral	0.11	neutral	2.51	neutral	-2.39	deleterious	-2.9	medium_impact	1.94	0.73	neutral	0.57	neutral	3.17	22.70	deleterious	0.07	0.35	0.49	neutral	0.67	disease	0.23	neutral	0.46	neutral	1	0.97	neutral	0.09	neutral	1	deleterious	0.69	deleterious	-1.96	low_impact	-0.33	medium_impact	0.56	medium_impact	0.19	0.8	20.31	24.77	0.38	N	0.81	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9880	9880	T	A	MI.8076	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	674	225	F	Y	tTt/tAt	3.14	0.16	0	benign	0	neutral	0.95	neutral	2.59	neutral	0.43	neutral	0.09	neutral_impact	0.18	0.8	neutral	0.96	neutral	-0.07	1.99	neutral	0.25	0.45	0.11	neutral	0.26	neutral	0.15	neutral	0.42	neutral	2	0.03	neutral	0.98	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.92	medium_impact	-1.02	low_impact	0.28	0.8	20.31	24.77	0.37	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9880	9880	T	C	MI.8077	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	674	225	F	S	tTt/tCt	3.14	0.16	0	possibly_damaging	0.46	neutral	0.44	neutral	2.56	neutral	1.26	neutral	-2.23	low_impact	0.96	0.76	neutral	0.78	neutral	3.10	22.50	deleterious	0.1	0.4	0.16	neutral	0.46	neutral	0.29	neutral	0.45	neutral	1	0.52	neutral	0.49	deleterious	-3	neutral	0.47	deleterious	-0.8	medium_impact	0.13	medium_impact	-0.32	medium_impact	0.19	0.8	20.31	24.77	0.35	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9881	9881	T	A	MI.8078	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	675	225	F	L	ttT/ttA	-0.1	0	0	benign	0.14	neutral	0.59	neutral	2.61	neutral	0.3	deleterious	-2.56	low_impact	1.42	0.74	neutral	0.69	neutral	1.84	15.22	deleterious	0.19	0.45	0.16	neutral	0.4	neutral	0.3	neutral	0.45	neutral	1	0.3	neutral	0.73	deleterious	-6	neutral	0.23	neutral	-0.1	medium_impact	0.28	medium_impact	0.09	medium_impact	0.33	0.8	20.31	24.77	0.31	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9881	9881	T	G	MI.8079	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	675	225	F	L	ttT/ttG	-0.1	0	0	benign	0.14	neutral	0.59	neutral	2.61	neutral	0.3	deleterious	-2.56	low_impact	1.42	0.74	neutral	0.69	neutral	1.77	14.83	neutral	0.19	0.45	0.16	neutral	0.4	neutral	0.3	neutral	0.45	neutral	1	0.3	neutral	0.73	deleterious	-6	neutral	0.23	neutral	-0.1	medium_impact	0.28	medium_impact	0.09	medium_impact	0.33	0.8	20.31	24.77	0.31	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8906	8906	A	T	MI.808	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	380	127	H	L	cAc/cTc	7.3	1	0	probably_damaging	0.99	deleterious	0.02	neutral	3.95	neutral	0.33	deleterious	-10.17	medium_impact	2.27	0.62	neutral	0.39	neutral	3.91	23.50	deleterious	0.35	0.65	0.51	disease	0.84	disease	0.75	disease	0.62	disease	2	1	deleterious	0.02	neutral	5	deleterious	0.79	deleterious	-2.65	low_impact	-0.66	medium_impact	0.85	medium_impact	0.31	0.9	50.44	8.73	0.48	N	0.96	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9882	9882	C	A	MI.8080	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	676	226	H	N	Cac/Aac	-3.57	0	0	probably_damaging	0.99	neutral	0.47	neutral	2.11	neutral	-2.02	deleterious	-6.13	medium_impact	2.54	0.61	neutral	0.25	damaging	4.04	23.70	deleterious	0.53	0.6	0.21	neutral	0.78	disease	0.68	disease	0.65	disease	3	0.99	deleterious	0.24	neutral	1	deleterious	0.74	deleterious	-2.81	low_impact	0.16	medium_impact	1.09	medium_impact	0.22	0.8	74.33	11.46	0.24	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9882	9882	C	G	MI.8081	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	676	226	H	D	Cac/Gac	-3.57	0	0	probably_damaging	1	neutral	0.18	neutral	2.13	neutral	-1.68	deleterious	-7.92	medium_impact	2.88	0.64	neutral	0.26	damaging	4.03	23.70	deleterious	0.1	0.4	0.24	neutral	0.78	disease	0.71	disease	0.55	disease	1	1	deleterious	0.09	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	-0.18	medium_impact	1.4	medium_impact	0.24	0.8	74.33	11.46	0.31	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9882	9882	C	T	MI.8082	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	676	226	H	Y	Cac/Tac	-3.57	0	0	probably_damaging	0.99	neutral	0.64	neutral	2.06	deleterious	-3.74	deleterious	-5.35	high_impact	3.88	0.6	neutral	0.16	damaging	3.86	23.50	deleterious	0.39	0.5	0.48	neutral	0.87	disease	0.66	disease	0.73	disease	5	0.99	deleterious	0.33	neutral	2	deleterious	0.82	deleterious	-2.81	low_impact	0.33	medium_impact	2.3	high_impact	0.19	0.8	74.33	11.46	0.25	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9883	9883	A	C	MI.8083	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	677	226	H	P	cAc/cCc	5.45	1	0	probably_damaging	1	neutral	0.12	neutral	2.06	deleterious	-3.47	deleterious	-8.86	high_impact	4.08	0.56	damaging	0.25	damaging	3.38	22.90	deleterious	0.05	0.35	0.41	neutral	0.88	disease	0.68	disease	0.74	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.3	medium_impact	2.47	high_impact	0.16	0.8	74.33	11.46	0.51	P	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9883	9883	A	T	MI.8084	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	677	226	H	L	cAc/cTc	5.45	1	0	probably_damaging	0.99	neutral	0.54	neutral	2.08	neutral	-2.66	deleterious	-9.76	medium_impact	3.4	0.63	neutral	0.33	neutral	3.97	23.60	deleterious	0.11	0.4	0.31	neutral	0.86	disease	0.69	disease	0.68	disease	4	0.99	deleterious	0.28	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	0.23	medium_impact	1.86	medium_impact	0.16	0.8	74.33	11.46	0.47	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9883	9883	A	G	MI.8085	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	677	226	H	R	cAc/cGc	5.45	1	0	probably_damaging	0.99	neutral	0.21	neutral	2.13	neutral	-1.65	deleterious	-7	medium_impact	2.7	0.64	neutral	0.21	damaging	3.17	22.70	deleterious	0.25	0.45	0.2	neutral	0.86	disease	0.67	disease	0.73	disease	5	0.99	deleterious	0.11	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	-0.14	medium_impact	1.24	medium_impact	0.17	0.8	74.33	11.46	0.39	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9884	9884	C	G	MI.8086	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	678	226	H	Q	caC/caG	5.68	1	0	probably_damaging	1	neutral	0.24	neutral	2.16	neutral	-1.29	deleterious	-6.82	medium_impact	1.97	0.49	damaging	0.66	neutral	3.70	23.30	deleterious	0.35	0.5	0.21	neutral	0.61	disease	0.53	disease	0.42	neutral	2	1	deleterious	0.12	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	-0.09	medium_impact	0.58	medium_impact	0.23	0.8	74.33	11.46	0.5	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9884	9884	C	A	MI.8087	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	678	226	H	Q	caC/caA	5.68	1	0	probably_damaging	1	neutral	0.24	neutral	2.16	neutral	-1.29	deleterious	-6.82	medium_impact	1.97	0.49	damaging	0.66	neutral	3.98	23.60	deleterious	0.35	0.5	0.21	neutral	0.61	disease	0.53	disease	0.42	neutral	2	1	deleterious	0.12	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	-0.09	medium_impact	0.58	medium_impact	0.23	0.8	74.33	11.46	0.5	N	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9885	9885	T	G	MI.8088	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	679	227	F	V	Ttt/Gtt	-0.1	0.87	0	probably_damaging	1	neutral	0.49	neutral	2.16	neutral	-1.22	deleterious	-5.99	medium_impact	3.27	0.63	neutral	0.03	damaging	4.31	24.00	deleterious	0.11	0.4	0.14	neutral	0.85	disease	0.7	disease	0.69	disease	4	1	deleterious	0.25	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	0.18	medium_impact	1.75	medium_impact	0.28	0.8	74.71	11.66	0.26	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9885	9885	T	C	MI.8089	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	679	227	F	L	Ttt/Ctt	-0.1	0.87	0	probably_damaging	0.98	neutral	0.73	neutral	2.44	neutral	0.54	deleterious	-5.05	medium_impact	2.04	0.5	damaging	0.06	damaging	4.36	24.10	deleterious	0.21	0.45	0.12	neutral	0.64	disease	0.42	neutral	0.43	neutral	1	0.98	deleterious	0.38	neutral	1	deleterious	0.71	deleterious	-2.51	low_impact	0.44	medium_impact	0.65	medium_impact	0.54	0.8	74.71	11.66	0.26	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8906	8906	A	C	MI.809	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	380	127	H	P	cAc/cCc	7.3	1	0	probably_damaging	0.99	deleterious	0	neutral	3.76	neutral	-2.63	deleterious	-9.27	high_impact	4.41	0.52	damaging	0.38	neutral	3.30	22.90	deleterious	0.29	0.65	0.63	disease	0.88	disease	0.85	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.85	deleterious	-2.65	low_impact	-1.4	low_impact	2.68	high_impact	0.40	0.9	50.44	8.73	0.61	P	1.00	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9885	9885	T	A	MI.8090	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	679	227	F	I	Ttt/Att	-0.1	0.87	0	probably_damaging	0.99	neutral	0.41	neutral	2.16	neutral	-1.2	deleterious	-5.13	medium_impact	3.08	0.63	neutral	0.04	damaging	4.84	24.80	deleterious	0.15	0.45	0.19	neutral	0.84	disease	0.6	disease	0.68	disease	4	0.99	deleterious	0.21	neutral	1	deleterious	0.75	deleterious	-2.81	low_impact	0.1	medium_impact	1.58	medium_impact	0.44	0.8	74.71	11.66	0.28	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9886	9886	T	C	MI.8091	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	680	227	F	S	tTt/tCt	7.53	1	0	probably_damaging	1	neutral	0.52	neutral	2.06	neutral	-2.9	deleterious	-6.96	medium_impact	3.02	0.69	neutral	0.02	damaging	4.37	24.10	deleterious	0.03	0.35	0.27	neutral	0.81	disease	0.68	disease	0.65	disease	3	1	deleterious	0.26	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	0.21	medium_impact	1.52	medium_impact	0.16	0.8	74.71	11.66	0.41	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9886	9886	T	G	MI.8092	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	680	227	F	C	tTt/tGt	7.53	1	0	probably_damaging	1	neutral	0.2	neutral	2.04	deleterious	-4.36	deleterious	-6.95	high_impact	3.92	0.7	neutral	0.02	damaging	4.23	23.90	deleterious	0.05	0.35	0.48	neutral	0.87	disease	0.7	disease	0.75	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.15	medium_impact	2.33	high_impact	0.15	0.8	74.71	11.66	0.48	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9886	9886	T	A	MI.8093	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	680	227	F	Y	tTt/tAt	7.53	1	0	probably_damaging	0.98	neutral	1	neutral	2.07	neutral	-2.59	neutral	-2.25	low_impact	1.9	0.57	damaging	0.1	damaging	4.33	24.00	deleterious	0.16	0.45	0.29	neutral	0.79	disease	0.42	neutral	0.53	disease	1	0.98	deleterious	0.51	deleterious	-2	neutral	0.77	deleterious	-2.51	low_impact	1.9	high_impact	0.52	medium_impact	0.49	0.8	74.71	11.66	0.43	N	0.80	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9887	9887	T	G	MI.8094	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	681	227	F	L	ttT/ttG	5.68	1	0	probably_damaging	0.98	neutral	0.73	neutral	2.44	neutral	0.54	deleterious	-5.05	medium_impact	2.04	0.5	damaging	0.06	damaging	4.45	24.20	deleterious	0.21	0.45	0.12	neutral	0.64	disease	0.42	neutral	0.43	neutral	1	0.98	deleterious	0.38	neutral	1	deleterious	0.71	deleterious	-2.51	low_impact	0.44	medium_impact	0.65	medium_impact	0.54	0.8	74.71	11.66	0.43	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9887	9887	T	A	MI.8095	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	681	227	F	L	ttT/ttA	5.68	1	0	probably_damaging	0.98	neutral	0.73	neutral	2.44	neutral	0.54	deleterious	-5.05	medium_impact	2.04	0.5	damaging	0.06	damaging	4.58	24.40	deleterious	0.21	0.45	0.12	neutral	0.64	disease	0.42	neutral	0.43	neutral	1	0.98	deleterious	0.38	neutral	1	deleterious	0.71	deleterious	-2.51	low_impact	0.44	medium_impact	0.65	medium_impact	0.54	0.8	74.71	11.66	0.43	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9888	9888	A	C	MI.8096	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	682	228	T	P	Aca/Cca	-7.28	0	0	probably_damaging	1	neutral	0.21	neutral	2.03	deleterious	-3.65	deleterious	-3.39	medium_impact	3.38	0.48	damaging	0.05	damaging	3.66	23.20	deleterious	0.07	0.35	0.59	disease	0.83	disease	0.61	disease	0.73	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.81	deleterious	-3.78	low_impact	-0.14	medium_impact	1.85	medium_impact	0.29	0.8	73.18	12.16	0.27	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9888	9888	A	T	MI.8097	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	682	228	T	S	Aca/Tca	-7.28	0	0	probably_damaging	0.98	neutral	0.44	neutral	2.24	neutral	-1.25	neutral	0.07	neutral_impact	0.02	0.56	damaging	0.1	damaging	1.67	14.23	neutral	0.57	0.65	0.3	neutral	0.07	neutral	0.19	neutral	0.25	neutral	5	0.97	neutral	0.23	neutral	-2	neutral	0.65	deleterious	-2.51	low_impact	0.13	medium_impact	-1.17	low_impact	0.58	0.8	73.18	12.16	0.42	N	0.77	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9888	9888	A	G	MI.8098	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	682	228	T	A	Aca/Gca	-7.28	0	0	probably_damaging	0.98	neutral	0.54	neutral	2.13	neutral	-2.17	neutral	-1.92	medium_impact	3.13	0.51	damaging	0.04	damaging	3.63	23.20	deleterious	0.35	0.5	0.31	neutral	0.52	disease	0.63	disease	0.68	disease	4	0.97	neutral	0.28	neutral	1	deleterious	0.68	deleterious	-2.51	low_impact	0.23	medium_impact	1.62	medium_impact	0.28	0.8	73.18	12.16	0.26	N	0.44	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9889	9889	C	A	MI.8099	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	683	228	T	K	aCa/aAa	8.69	1	0	probably_damaging	1	neutral	0.33	neutral	2.08	neutral	-1.66	deleterious	-2.85	medium_impact	2.73	0.51	damaging	0.02	damaging	4.58	24.40	deleterious	0.11	0.4	0.33	neutral	0.83	disease	0.6	disease	0.73	disease	5	1	deleterious	0.17	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.02	medium_impact	1.26	medium_impact	0.33	0.8	73.18	12.16	0.45	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8561	8561	C	T	MI.81	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	35	12	P	L	cCc/cTc	7.3	1	0	probably_damaging	1	deleterious	0.04	neutral	4.63	neutral	0.66	deleterious	-8.73	medium_impact	2.67	0.58	damaging	0.05	damaging	4.18	23.80	deleterious	0.37	0.65	0.27	neutral	0.89	disease	0.71	disease	0.79	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.74	deleterious	-3.6	low_impact	-0.49	medium_impact	1.19	medium_impact	0.80	0.9	50	8.94	0.43	N	0.97	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8907	8907	C	G	MI.810	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	381	127	H	Q	caC/caG	6.84	1	0	probably_damaging	0.99	deleterious	0.01	neutral	3.76	neutral	-2.32	deleterious	-7.39	medium_impact	3.25	0.61	neutral	0.38	neutral	3.63	23.20	deleterious	0.56	0.65	0.69	disease	0.83	disease	0.77	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-2.65	low_impact	-0.84	medium_impact	1.69	medium_impact	0.56	0.9	50.44	8.73	0.49	N	0.95	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9889	9889	C	T	MI.8100	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	683	228	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	neutral	0.22	neutral	2.02	deleterious	-4.12	deleterious	-3.36	medium_impact	3.38	0.51	damaging	0.01	damaging	4.13	23.80	deleterious	0.11	0.4	0.56	disease	0.65	disease	0.64	disease	0.69	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	-0.12	medium_impact	1.85	medium_impact	0.41	0.8	73.18	12.16	0.5	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9891	9891	T	A	MI.8101	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	685	229	S	T	Tcc/Acc	-0.1	0.28	0	benign	0.08	neutral	0.71	neutral	2.29	neutral	-1	neutral	-0.1	neutral_impact	0.69	0.73	neutral	0.78	neutral	0.63	8.36	deleterious	0.57	0.65	0.23	neutral	0.34	neutral	0.18	neutral	0.45	neutral	1	0.19	neutral	0.82	deleterious	-6	neutral	0.17	neutral	0.16	medium_impact	0.41	medium_impact	-0.56	medium_impact	0.42	0.8	36.78	13.35	0.36	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9891	9891	T	C	MI.8102	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	685	229	S	P	Tcc/Ccc	-0.1	0.28	0	benign	0.01	neutral	0.34	neutral	2.21	neutral	0.02	neutral	-2.12	neutral_impact	0.73	0.78	neutral	0.73	neutral	1.02	10.77	neutral	0.17	0.45	0.23	neutral	0.68	disease	0.19	neutral	0.44	neutral	1	0.65	neutral	0.67	deleterious	-6	neutral	0.19	neutral	1.07	medium_impact	0.03	medium_impact	-0.53	medium_impact	0.15	0.8	36.78	13.35	0.41	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9891	9891	T	G	MI.8103	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	685	229	S	A	Tcc/Gcc	-0.1	0.28	0	benign	0.08	neutral	0.91	neutral	2.29	neutral	0.25	neutral	-1.55	low_impact	1.5	0.74	neutral	0.8	neutral	1.17	11.56	neutral	0.62	0.65	0.17	neutral	0.36	neutral	0.31	neutral	0.45	neutral	1	0.03	neutral	0.92	deleterious	-6	neutral	0.15	neutral	0.16	medium_impact	0.76	medium_impact	0.16	medium_impact	0.25	0.8	36.78	13.35	0.3	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9892	9892	C	T	MI.8104	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	686	229	S	F	tCc/tTc	0.36	0.33	0	possibly_damaging	0.89	neutral	0.44	neutral	2.2	deleterious	-3.42	deleterious	-3.73	low_impact	1.83	0.62	neutral	0.48	neutral	4.33	24.00	deleterious	0.13	0.4	0.54	disease	0.79	disease	0.49	neutral	0.62	disease	2	0.89	neutral	0.28	neutral	-3	neutral	0.74	deleterious	-1.75	low_impact	0.13	medium_impact	0.46	medium_impact	0.03	0.8	36.78	13.35	0.26	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9892	9892	C	A	MI.8105	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	686	229	S	Y	tCc/tAc	0.36	0.33	0	possibly_damaging	0.89	neutral	0.53	neutral	2.22	deleterious	-3.21	deleterious	-3.46	medium_impact	2.29	0.65	neutral	0.33	neutral	4.32	24.00	deleterious	0.14	0.4	0.38	neutral	0.82	disease	0.5	neutral	0.66	disease	3	0.88	neutral	0.32	neutral	0	NA	0.71	deleterious	-1.75	low_impact	0.22	medium_impact	0.87	medium_impact	0.15	0.8	36.78	13.35	0.23	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9892	9892	C	G	MI.8106	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	686	229	S	C	tCc/tGc	0.36	0.33	0	possibly_damaging	0.82	neutral	0.13	neutral	2.18	deleterious	-4.66	deleterious	-3.04	medium_impact	3.19	0.64	neutral	0.39	neutral	3.68	23.30	deleterious	0.14	0.4	0.68	disease	0.76	disease	0.37	neutral	0.59	disease	2	0.93	neutral	0.16	neutral	0	NA	0.70	deleterious	-1.51	low_impact	-0.28	medium_impact	1.68	medium_impact	0.19	0.8	36.78	13.35	0.36	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9894	9894	A	G	MI.8107	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	688	230	K	E	Aaa/Gaa	-20	0	0	benign	0.05	neutral	1	neutral	2.34	neutral	0.31	neutral	-0.16	neutral_impact	0.08	0.72	neutral	0.45	neutral	0.10	3.66	deleterious	0.22	0.45	0.12	neutral	0.38	neutral	0.43	neutral	0.43	neutral	1	0.05	neutral	0.98	deleterious	-6	neutral	0.12	neutral	0.37	medium_impact	1.9	high_impact	-1.11	low_impact	0.51	0.8	NA	NA	0.27	N	0.56	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9894	9894	A	C	MI.8108	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	688	230	K	Q	Aaa/Caa	-20	0	0	benign	0.14	neutral	0.61	neutral	2.31	neutral	-0.84	neutral	-0.27	neutral_impact	0.25	0.73	neutral	0.48	neutral	0.12	3.84	deleterious	0.38	0.5	0.17	neutral	0.29	neutral	0.24	neutral	0.43	neutral	1	0.28	neutral	0.74	deleterious	-6	neutral	0.14	neutral	-0.1	medium_impact	0.3	medium_impact	-0.96	medium_impact	0.36	0.8	NA	NA	0.36	N	0.62	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9895	9895	A	T	MI.8109	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	689	230	K	M	aAa/aTa	1.98	0	0	possibly_damaging	0.56	neutral	0.26	neutral	2.22	deleterious	-3.15	neutral	-1.23	low_impact	1.85	0.77	neutral	0.35	neutral	3.83	23.40	deleterious	0.13	0.4	0.44	neutral	0.3	neutral	0.41	neutral	0.46	neutral	1	0.74	neutral	0.35	neutral	-3	neutral	0.45	deleterious	-0.97	medium_impact	-0.07	medium_impact	0.48	medium_impact	0.28	0.8	NA	NA	0.41	N	0.72	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8907	8907	C	A	MI.811	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	381	127	H	Q	caC/caA	6.84	1	0	probably_damaging	0.99	deleterious	0.01	neutral	3.76	neutral	-2.32	deleterious	-7.39	medium_impact	3.25	0.61	neutral	0.38	neutral	3.90	23.50	deleterious	0.56	0.65	0.69	disease	0.83	disease	0.77	disease	0.73	disease	5	1	deleterious	0.01	neutral	5	deleterious	0.81	deleterious	-2.65	low_impact	-0.84	medium_impact	1.69	medium_impact	0.56	0.9	50.44	8.73	0.49	P	0.95	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9895	9895	A	C	MI.8110	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	689	230	K	T	aAa/aCa	1.98	0	0	benign	0.05	neutral	0.69	neutral	2.29	neutral	-1.14	neutral	0.63	neutral_impact	0.16	0.78	neutral	0.87	neutral	-0.22	1.00	neutral	0.15	0.45	0.19	neutral	0.21	neutral	0.24	neutral	0.35	neutral	3	0.24	neutral	0.82	deleterious	-6	neutral	0.12	neutral	0.37	medium_impact	0.39	medium_impact	-1.04	low_impact	0.25	0.8	NA	NA	0.29	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9896	9896	A	T	MI.8111	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	690	230	K	N	aaA/aaT	0.36	0	0	benign	0	neutral	0.61	neutral	2.32	neutral	-0.94	neutral	1.46	neutral_impact	-0.22	0.77	neutral	0.96	neutral	-0.60	0.13	neutral	0.47	0.55	0.12	neutral	0.19	neutral	0.21	neutral	0.35	neutral	3	0.39	neutral	0.81	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.3	medium_impact	-1.38	low_impact	0.33	0.8	NA	NA	0.33	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9896	9896	A	C	MI.8112	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	690	230	K	N	aaA/aaC	0.36	0	0	benign	0	neutral	0.61	neutral	2.32	neutral	-0.94	neutral	1.46	neutral_impact	-0.22	0.77	neutral	0.96	neutral	-0.64	0.10	neutral	0.47	0.55	0.12	neutral	0.19	neutral	0.21	neutral	0.35	neutral	3	0.39	neutral	0.81	deleterious	-6	neutral	0.10	neutral	2.05	high_impact	0.3	medium_impact	-1.38	low_impact	0.33	0.8	NA	NA	0.32	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9897	9897	C	G	MI.8113	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	691	231	H	D	Cat/Gat	-6.81	0	0	probably_damaging	0.99	neutral	0.2	neutral	1.94	deleterious	-3.1	deleterious	-8.22	medium_impact	2.73	0.58	damaging	0.02	damaging	4.04	23.70	deleterious	0.06	0.35	0.24	neutral	0.85	disease	0.78	disease	0.76	disease	5	1	deleterious	0.11	neutral	1	deleterious	0.77	deleterious	-2.81	low_impact	-0.15	medium_impact	1.26	medium_impact	0.51	0.8	73.95	12.04	0.31	N	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9897	9897	C	T	MI.8114	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	691	231	H	Y	Cat/Tat	-6.81	0	0	probably_damaging	0.98	neutral	1	neutral	1.91	deleterious	-3.8	deleterious	-5.48	high_impact	3.62	0.58	damaging	0.02	damaging	3.86	23.50	deleterious	0.24	0.45	0.32	neutral	0.88	disease	0.78	disease	0.78	disease	6	0.98	deleterious	0.51	deleterious	2	deleterious	0.81	deleterious	-2.51	low_impact	1.9	high_impact	2.06	high_impact	0.32	0.8	73.95	12.04	0.28	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9897	9897	C	A	MI.8115	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	691	231	H	N	Cat/Aat	-6.81	0	0	probably_damaging	0.99	neutral	0.4	neutral	1.94	deleterious	-3.14	deleterious	-6.38	medium_impact	2.03	0.56	damaging	0.02	damaging	4.27	23.90	deleterious	0.37	0.5	0.21	neutral	0.82	disease	0.73	disease	0.63	disease	3	0.99	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	0.09	medium_impact	0.64	medium_impact	0.37	0.8	73.95	12.04	0.2	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9898	9898	A	C	MI.8116	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	692	231	H	P	cAt/cCt	5.45	1	0	probably_damaging	1	neutral	0.23	neutral	1.9	deleterious	-4.35	deleterious	-9.13	high_impact	3.96	0.56	damaging	0.02	damaging	3.28	22.80	deleterious	0.04	0.35	0.4	neutral	0.89	disease	0.77	disease	0.79	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.11	medium_impact	2.37	high_impact	0.16	0.8	73.95	12.04	0.5	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9898	9898	A	T	MI.8117	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	692	231	H	L	cAt/cTt	5.45	1	0	probably_damaging	0.98	neutral	0.67	neutral	1.93	deleterious	-3.21	deleterious	-10.04	high_impact	3.96	0.56	damaging	0.02	damaging	3.84	23.40	deleterious	0.09	0.35	0.21	neutral	0.88	disease	0.77	disease	0.77	disease	5	0.98	deleterious	0.35	neutral	2	deleterious	0.78	deleterious	-2.51	low_impact	0.37	medium_impact	2.37	high_impact	0.13	0.8	73.95	12.04	0.49	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9898	9898	A	G	MI.8118	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	692	231	H	R	cAt/cGt	5.45	1	0	probably_damaging	0.98	neutral	0.35	neutral	2.02	neutral	-1.75	deleterious	-7.31	medium_impact	2.34	0.63	neutral	0.03	damaging	3.08	22.50	deleterious	0.19	0.45	0.19	neutral	0.84	disease	0.71	disease	0.54	disease	1	0.99	deleterious	0.19	neutral	1	deleterious	0.79	deleterious	-2.51	low_impact	0.04	medium_impact	0.92	medium_impact	0.15	0.8	73.95	12.04	0.32	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9899	9899	T	A	MI.8119	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	693	231	H	Q	caT/caA	8.69	1	0.02	probably_damaging	0.99	neutral	0.31	neutral	1.95	neutral	-2.81	deleterious	-7.31	medium_impact	2.09	0.5	damaging	0.05	damaging	3.87	23.50	deleterious	0.26	0.45	0.18	neutral	0.73	disease	0.73	disease	0.59	disease	2	0.99	deleterious	0.16	neutral	1	deleterious	0.74	deleterious	-2.81	low_impact	-0.01	medium_impact	0.69	medium_impact	0.39	0.8	73.95	12.04	0.42	N	0.94	polymorphism	1	0.10	rs41345446	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8908	8908	T	A	MI.812	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	382	128	F	I	Ttc/Atc	-1.95	0	0	benign	0.02	neutral	0.08	neutral	4.34	neutral	-2.18	neutral	-1.03	medium_impact	2.21	0.86	neutral	0.59	neutral	2.66	20.60	deleterious	0.26	0.65	0.64	disease	0.46	neutral	0.56	disease	0.64	disease	3	0.92	neutral	0.53	deleterious	-3	neutral	0.23	neutral	0.85	medium_impact	-0.31	medium_impact	0.8	medium_impact	0.51	0.9	19.91	15.56	0.42	N	0.75	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9899	9899	T	G	MI.8120	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	693	231	H	Q	caT/caG	8.69	1	0.02	probably_damaging	0.99	neutral	0.31	neutral	1.95	neutral	-2.81	deleterious	-7.31	medium_impact	2.09	0.5	damaging	0.05	damaging	3.74	23.30	deleterious	0.26	0.45	0.18	neutral	0.73	disease	0.73	disease	0.59	disease	2	0.99	deleterious	0.16	neutral	1	deleterious	0.74	deleterious	-2.81	low_impact	-0.01	medium_impact	0.69	medium_impact	0.39	0.8	73.95	12.04	0.4	N	0.94	polymorphism	1	0.10	rs41345446	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9900	9900	C	G	MI.8121	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	694	232	H	D	Cac/Gac	-2.88	0	0	probably_damaging	1	neutral	0.16	neutral	2	neutral	-2.4	deleterious	-8.18	high_impact	3.69	0.61	neutral	0.02	damaging	3.98	23.60	deleterious	0.06	0.35	0.29	neutral	0.88	disease	0.8	disease	0.79	disease	6	1	deleterious	0.08	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.22	medium_impact	2.12	high_impact	0.16	0.8	73.56	11.8	0.39	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9900	9900	C	A	MI.8122	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	694	232	H	N	Cac/Aac	-2.88	0	0	probably_damaging	0.99	neutral	0.37	neutral	2.03	neutral	-1.98	deleterious	-6.37	high_impact	3.52	0.59	damaging	0.02	damaging	4.15	23.80	deleterious	0.23	0.45	0.28	neutral	0.87	disease	0.77	disease	0.73	disease	5	0.99	deleterious	0.19	neutral	2	deleterious	0.78	deleterious	-2.81	low_impact	0.06	medium_impact	1.97	medium_impact	0.14	0.8	73.56	11.8	0.33	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9900	9900	C	T	MI.8123	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	694	232	H	Y	Cac/Tac	-2.88	0	0	probably_damaging	0.99	neutral	0.82	neutral	1.95	deleterious	-3.58	deleterious	-5.47	medium_impact	2.17	0.51	damaging	0.04	damaging	3.84	23.40	deleterious	0.18	0.45	0.19	neutral	0.9	disease	0.73	disease	0.72	disease	4	0.99	deleterious	0.42	neutral	1	deleterious	0.79	deleterious	-2.81	low_impact	0.57	medium_impact	0.76	medium_impact	0.10	0.8	73.56	11.8	0.25	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9901	9901	A	T	MI.8124	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	695	232	H	L	cAc/cTc	5.45	1	0	probably_damaging	1	neutral	0.6	neutral	1.96	deleterious	-3.22	deleterious	-9.99	medium_impact	3.46	0.58	damaging	0.02	damaging	3.99	23.60	deleterious	0.06	0.35	0.26	neutral	0.92	disease	0.77	disease	0.78	disease	6	1	deleterious	0.3	neutral	1	deleterious	0.82	deleterious	-3.78	low_impact	0.29	medium_impact	1.92	medium_impact	0.10	0.8	73.56	11.8	0.45	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9901	9901	A	G	MI.8125	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	695	232	H	R	cAc/cGc	5.45	1	0	probably_damaging	1	neutral	0.32	neutral	1.99	neutral	-2.53	deleterious	-7.28	high_impact	3.95	0.7	neutral	0.02	damaging	3.18	22.70	deleterious	0.09	0.35	0.27	neutral	0.9	disease	0.75	disease	0.77	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.01	medium_impact	2.36	high_impact	0.17	0.8	73.56	11.8	0.48	N	0.99	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9901	9901	A	C	MI.8126	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	695	232	H	P	cAc/cCc	5.45	1	0	probably_damaging	1	neutral	0.16	neutral	1.94	deleterious	-4.12	deleterious	-9.09	high_impact	3.95	0.57	damaging	0.03	damaging	3.32	22.90	deleterious	0.04	0.35	0.32	neutral	0.89	disease	0.74	disease	0.77	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.22	medium_impact	2.36	high_impact	0.06	0.8	73.56	11.8	0.47	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9902	9902	C	A	MI.8127	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	696	232	H	Q	caC/caA	8.69	1	0	probably_damaging	1	neutral	0.25	neutral	1.98	neutral	-2.74	deleterious	-7.28	medium_impact	3.46	0.64	neutral	0.02	damaging	4.05	23.70	deleterious	0.14	0.4	0.25	neutral	0.85	disease	0.79	disease	0.77	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	-0.08	medium_impact	1.92	medium_impact	0.19	0.8	73.56	11.8	0.48	P	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9902	9902	C	G	MI.8128	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	696	232	H	Q	caC/caG	8.69	1	0	probably_damaging	1	neutral	0.25	neutral	1.98	neutral	-2.74	deleterious	-7.28	medium_impact	3.46	0.64	neutral	0.02	damaging	3.77	23.40	deleterious	0.14	0.4	0.25	neutral	0.85	disease	0.79	disease	0.77	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	-0.08	medium_impact	1.92	medium_impact	0.19	0.8	73.56	11.8	0.48	P	0.94	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9903	9903	T	G	MI.8129	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	697	233	F	V	Ttt/Gtt	-1.26	0	0	probably_damaging	0.99	neutral	0.21	neutral	2.4	neutral	0.69	deleterious	-5.47	medium_impact	2.17	0.5	damaging	0.74	neutral	4.25	23.90	deleterious	0.1	0.4	0.12	neutral	0.69	disease	0.37	neutral	0.49	neutral	0	1	deleterious	0.11	neutral	1	deleterious	0.70	deleterious	-2.81	low_impact	-0.14	medium_impact	0.76	medium_impact	0.28	0.8	75.1	11.59	0.4	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8908	8908	T	C	MI.813	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	382	128	F	L	Ttc/Ctc	-1.95	0	0	benign	0	neutral	1	neutral	4.64	neutral	-0.75	neutral	0.09	neutral_impact	-0.74	0.93	neutral	0.95	neutral	-0.45	0.29	neutral	0.44	0.65	0.26	neutral	0.12	neutral	0.24	neutral	0.29	neutral	4	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.98	high_impact	-1.73	low_impact	0.73	0.9	19.91	15.56	0.34	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9903	9903	T	C	MI.8130	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	697	233	F	L	Ttt/Ctt	-1.26	0	0	probably_damaging	0.98	neutral	0.46	neutral	2.42	neutral	0.84	deleterious	-4.7	low_impact	1.88	0.48	damaging	0.78	neutral	4.33	24.00	deleterious	0.15	0.45	0.14	neutral	0.62	disease	0.37	neutral	0.44	neutral	1	0.97	neutral	0.24	neutral	-2	neutral	0.71	deleterious	-2.51	low_impact	0.15	medium_impact	0.5	medium_impact	0.50	0.8	75.1	11.59	0.47	N	0.92	polymorphism	1	0.08	rs199999390	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9903	9903	T	A	MI.8131	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	697	233	F	I	Ttt/Att	-1.26	0	0	probably_damaging	0.98	neutral	0.33	neutral	2.33	neutral	0.09	deleterious	-4.66	medium_impact	2.84	0.64	neutral	0.63	neutral	4.81	24.80	deleterious	0.14	0.4	0.15	neutral	0.82	disease	0.53	disease	0.51	disease	0	0.99	deleterious	0.18	neutral	1	deleterious	0.75	deleterious	-2.51	low_impact	0.02	medium_impact	1.36	medium_impact	0.43	0.8	75.1	11.59	0.32	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9904	9904	T	C	MI.8132	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	698	233	F	S	tTt/tCt	5.68	1	0	probably_damaging	1	neutral	0.21	neutral	2.25	neutral	-1	deleterious	-6.67	high_impact	4.01	0.78	neutral	0.58	neutral	4.38	24.10	deleterious	0.04	0.35	0.21	neutral	0.81	disease	0.65	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.75	deleterious	-3.78	low_impact	-0.14	medium_impact	2.41	high_impact	0.16	0.8	75.1	11.59	0.51	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	COSM1636304	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9904	9904	T	A	MI.8133	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	698	233	F	Y	tTt/tAt	5.68	1	0	probably_damaging	0.98	neutral	0.46	neutral	2.24	neutral	-1.31	neutral	-2.5	medium_impact	3.27	0.68	neutral	0.43	neutral	4.33	24.00	deleterious	0.21	0.45	0.35	neutral	0.83	disease	0.55	disease	0.71	disease	4	0.97	neutral	0.24	neutral	1	deleterious	0.77	deleterious	-2.51	low_impact	0.15	medium_impact	1.75	medium_impact	0.52	0.8	75.1	11.59	0.53	P	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9904	9904	T	G	MI.8134	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	698	233	F	C	tTt/tGt	5.68	1	0	probably_damaging	1	neutral	0.07	neutral	2.21	neutral	-2.57	deleterious	-6.59	high_impact	4.01	0.69	neutral	0.47	neutral	4.22	23.90	deleterious	0.06	0.35	0.48	neutral	0.88	disease	0.66	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.45	medium_impact	2.41	high_impact	0.10	0.8	75.1	11.59	0.52	P	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9905	9905	T	G	MI.8135	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	699	233	F	L	ttT/ttG	4.76	1	0	probably_damaging	0.98	neutral	0.46	neutral	2.42	neutral	0.84	deleterious	-4.7	low_impact	1.88	0.48	damaging	0.78	neutral	4.48	24.20	deleterious	0.15	0.45	0.14	neutral	0.62	disease	0.37	neutral	0.44	neutral	1	0.97	neutral	0.24	neutral	-2	neutral	0.71	deleterious	-2.51	low_impact	0.15	medium_impact	0.5	medium_impact	0.50	0.8	75.1	11.59	0.58	P	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9905	9905	T	A	MI.8136	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	699	233	F	L	ttT/ttA	4.76	1	0	probably_damaging	0.98	neutral	0.46	neutral	2.42	neutral	0.84	deleterious	-4.7	low_impact	1.88	0.48	damaging	0.78	neutral	4.57	24.40	deleterious	0.15	0.45	0.14	neutral	0.62	disease	0.37	neutral	0.44	neutral	1	0.97	neutral	0.24	neutral	-2	neutral	0.71	deleterious	-2.51	low_impact	0.15	medium_impact	0.5	medium_impact	0.50	0.8	75.1	11.59	0.57	P	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9906	9906	G	A	MI.8137	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	700	234	G	S	Ggc/Agc	-4.04	0	0	probably_damaging	1	neutral	0.4	neutral	1.82	neutral	-2.83	deleterious	-5.41	medium_impact	2.62	0.54	damaging	0.02	damaging	4.34	24.10	deleterious	0.08	0.35	0.26	neutral	0.71	disease	0.61	disease	0.61	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-3.78	low_impact	0.09	medium_impact	1.17	medium_impact	0.56	0.8	74.33	11.76	0.22	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9906	9906	G	T	MI.8138	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	700	234	G	C	Ggc/Tgc	-4.04	0	0	probably_damaging	1	neutral	0.17	neutral	1.73	deleterious	-5.65	deleterious	-8.11	high_impact	3.99	0.54	damaging	0.02	damaging	4.33	24.00	deleterious	0.05	0.35	0.66	disease	0.86	disease	0.72	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.2	medium_impact	2.39	high_impact	0.13	0.8	74.33	11.76	0.3	N	0.98	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9906	9906	G	C	MI.8139	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	700	234	G	R	Ggc/Cgc	-4.04	0	0	probably_damaging	1	neutral	0.36	neutral	1.76	deleterious	-4.05	deleterious	-7.21	high_impact	4.2	0.61	neutral	0.02	damaging	4.08	23.70	deleterious	0.04	0.35	0.32	neutral	0.84	disease	0.75	disease	0.77	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	0.05	medium_impact	2.58	high_impact	0.42	0.8	74.33	11.76	0.35	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8908	8908	T	G	MI.814	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	382	128	F	V	Ttc/Gtc	-1.95	0	0	benign	0.03	neutral	0.09	neutral	4.4	neutral	-2.05	neutral	-1.94	medium_impact	2.9	0.89	neutral	0.56	neutral	2.27	17.99	deleterious	0.34	0.65	0.59	disease	0.62	disease	0.7	disease	0.73	disease	5	0.91	neutral	0.53	deleterious	-3	neutral	0.23	neutral	0.68	medium_impact	-0.28	medium_impact	1.39	medium_impact	0.48	0.9	19.91	15.56	0.41	N	0.86	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9907	9907	G	C	MI.8140	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	701	234	G	A	gGc/gCc	4.29	1	0	probably_damaging	1	neutral	0.53	neutral	1.83	neutral	-2.65	deleterious	-5.41	medium_impact	2.48	0.56	damaging	0.01	damaging	3.22	22.70	deleterious	0.13	0.4	0.19	neutral	0.61	disease	0.7	disease	0.64	disease	3	1	deleterious	0.27	neutral	1	deleterious	0.73	deleterious	-3.78	low_impact	0.22	medium_impact	1.04	medium_impact	0.32	0.8	74.33	11.76	0.32	N	0.30	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9907	9907	G	A	MI.8141	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	701	234	G	D	gGc/gAc	4.29	1	0	probably_damaging	1	neutral	0.22	neutral	1.79	deleterious	-3.2	deleterious	-6.31	high_impact	3.64	0.48	damaging	0.02	damaging	3.94	23.50	deleterious	0.03	0.35	0.35	neutral	0.84	disease	0.77	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.12	medium_impact	2.08	high_impact	0.10	0.8	74.33	11.76	0.48	P	0.98	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9907	9907	G	T	MI.8142	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	701	234	G	V	gGc/gTc	4.29	1	0	probably_damaging	1	neutral	0.5	neutral	1.76	deleterious	-4.1	deleterious	-8.11	high_impact	4.54	0.51	damaging	0.01	damaging	3.91	23.50	deleterious	0.05	0.35	0.26	neutral	0.83	disease	0.73	disease	0.74	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	0.19	medium_impact	2.89	high_impact	0.10	0.8	74.33	11.76	0.45	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9909	9909	T	A	MI.8143	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	703	235	F	I	Ttc/Atc	-10.05	0	0	probably_damaging	0.99	neutral	0.38	neutral	1.88	neutral	-2.98	deleterious	-5.2	medium_impact	2.94	0.79	neutral	0.58	neutral	4.61	24.40	deleterious	0.09	0.35	0.15	neutral	0.83	disease	0.68	disease	0.72	disease	4	0.99	deleterious	0.2	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	0.07	medium_impact	1.45	medium_impact	0.47	0.8	73.18	12.06	0.29	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9909	9909	T	G	MI.8144	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	703	235	F	V	Ttc/Gtc	-10.05	0	0	probably_damaging	1	neutral	0.48	neutral	1.89	neutral	-2.91	deleterious	-6.06	medium_impact	2.21	0.67	neutral	0.53	neutral	4.30	24.00	deleterious	0.09	0.35	0.14	neutral	0.81	disease	0.67	disease	0.7	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.72	deleterious	-3.78	low_impact	0.17	medium_impact	0.8	medium_impact	0.31	0.8	73.18	12.06	0.27	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9909	9909	T	C	MI.8145	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	703	235	F	L	Ttc/Ctc	-10.05	0	0	probably_damaging	0.98	neutral	0.61	neutral	2.03	neutral	-1.33	deleterious	-5.21	low_impact	1.49	0.51	damaging	0.73	neutral	4.26	23.90	deleterious	0.11	0.4	0.13	neutral	0.62	disease	0.4	neutral	0.41	neutral	2	0.98	deleterious	0.32	neutral	-2	neutral	0.72	deleterious	-2.51	low_impact	0.3	medium_impact	0.15	medium_impact	0.59	0.8	73.18	12.06	0.36	N	0.92	polymorphism	1	0.09	rs28690056	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9910	9910	T	G	MI.8146	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	704	235	F	C	tTc/tGc	5.68	1	0	probably_damaging	1	neutral	0.17	neutral	1.82	deleterious	-5.55	deleterious	-6.94	high_impact	3.98	0.71	neutral	0.48	neutral	4.28	24.00	deleterious	0.03	0.35	0.33	neutral	0.84	disease	0.59	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	-0.2	medium_impact	2.38	high_impact	0.24	0.8	73.18	12.06	0.47	N	0.98	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9910	9910	T	C	MI.8147	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	704	235	F	S	tTc/tCc	5.68	1	0	probably_damaging	1	neutral	0.42	neutral	1.84	deleterious	-4.01	deleterious	-6.97	high_impact	3.79	0.84	neutral	0.55	neutral	4.43	24.20	deleterious	0.03	0.35	0.34	neutral	0.77	disease	0.69	disease	0.7	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	0.11	medium_impact	2.21	high_impact	0.34	0.8	73.18	12.06	0.5	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9910	9910	T	A	MI.8148	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	704	235	F	Y	tTc/tAc	5.68	1	0	probably_damaging	0.98	neutral	1	neutral	2.06	neutral	-1.14	neutral	-2.43	medium_impact	2.44	0.61	neutral	0.69	neutral	4.38	24.10	deleterious	0.09	0.35	0.33	neutral	0.74	disease	0.43	neutral	0.52	disease	0	0.98	deleterious	0.51	deleterious	1	deleterious	0.77	deleterious	-2.51	low_impact	1.9	high_impact	1	medium_impact	0.56	0.8	73.18	12.06	0.49	N	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9911	9911	C	G	MI.8149	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	705	235	F	L	ttC/ttG	5.68	1	0	probably_damaging	0.98	neutral	0.61	neutral	2.03	neutral	-1.33	deleterious	-5.21	low_impact	1.49	0.51	damaging	0.73	neutral	4.51	24.30	deleterious	0.11	0.4	0.13	neutral	0.62	disease	0.4	neutral	0.41	neutral	2	0.98	deleterious	0.32	neutral	-2	neutral	0.72	deleterious	-2.51	low_impact	0.3	medium_impact	0.15	medium_impact	0.59	0.8	73.18	12.06	0.43	N	0.92	polymorphism	1	0.09	rs28615236	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8909	8909	T	C	MI.815	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	383	128	F	S	tTc/tCc	0.36	0.04	0	benign	0.11	deleterious	0	neutral	4.29	deleterious	-3.19	deleterious	-3.96	medium_impact	3.1	0.82	neutral	0.52	neutral	2.40	18.82	deleterious	0.31	0.65	0.39	neutral	0.6	disease	0.68	disease	0.71	disease	4	1	deleterious	0.45	neutral	1	deleterious	0.28	neutral	0.11	medium_impact	-1.4	low_impact	1.56	medium_impact	0.37	0.9	19.91	15.56	0.41	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9911	9911	C	A	MI.8150	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	705	235	F	L	ttC/ttA	5.68	1	0	probably_damaging	0.98	neutral	0.61	neutral	2.03	neutral	-1.33	deleterious	-5.21	low_impact	1.49	0.51	damaging	0.73	neutral	4.78	24.70	deleterious	0.11	0.4	0.13	neutral	0.62	disease	0.4	neutral	0.41	neutral	2	0.98	deleterious	0.32	neutral	-2	neutral	0.72	deleterious	-2.51	low_impact	0.3	medium_impact	0.15	medium_impact	0.59	0.8	73.18	12.06	0.5	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9912	9912	G	C	MI.8151	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	706	236	E	Q	Gaa/Caa	-2.42	0	0	probably_damaging	0.98	neutral	0.29	neutral	1.79	deleterious	-3.37	deleterious	-2.68	medium_impact	3	0.53	damaging	0.75	neutral	3.46	23.00	deleterious	0.14	0.4	0.22	neutral	0.82	disease	0.75	disease	0.75	disease	5	0.98	deleterious	0.16	neutral	1	deleterious	0.76	deleterious	-2.51	low_impact	-0.03	medium_impact	1.51	medium_impact	0.50	0.8	73.56	11.71	0.42	N	0.01	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9912	9912	G	A	MI.8152	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	706	236	E	K	Gaa/Aaa	-2.42	0	0	probably_damaging	0.98	neutral	0.29	neutral	1.82	neutral	-2.81	deleterious	-3.57	medium_impact	3.08	0.39	damaging	0.47	neutral	4.61	24.40	deleterious	0.05	0.35	0.19	neutral	0.89	disease	0.71	disease	0.76	disease	5	0.98	deleterious	0.16	neutral	1	deleterious	0.80	deleterious	-2.51	low_impact	-0.03	medium_impact	1.58	medium_impact	0.66	0.8	73.56	11.71	0.62	P	0.88	polymorphism	1	0.12	rs28580363	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9913	9913	A	G	MI.8153	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	707	236	E	G	gAa/gGa	6.14	1	0	probably_damaging	0.99	neutral	0.33	neutral	1.77	deleterious	-3.92	deleterious	-6.24	high_impact	3.98	0.49	damaging	0.69	neutral	4.42	24.20	deleterious	0.04	0.35	0.34	neutral	0.85	disease	0.75	disease	0.77	disease	5	0.99	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-2.81	low_impact	0.02	medium_impact	2.38	high_impact	0.24	0.8	73.56	11.71	0.56	P	0.83	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9913	9913	A	C	MI.8154	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	707	236	E	A	gAa/gCa	6.14	1	0	probably_damaging	0.98	neutral	0.51	neutral	1.8	deleterious	-3.21	deleterious	-5.35	medium_impact	3.49	0.56	damaging	0.63	neutral	3.92	23.50	deleterious	0.05	0.35	0.19	neutral	0.8	disease	0.73	disease	0.71	disease	4	0.98	deleterious	0.27	neutral	1	deleterious	0.76	deleterious	-2.51	low_impact	0.2	medium_impact	1.95	medium_impact	0.30	0.8	73.56	11.71	0.5	N	0.59	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9913	9913	A	T	MI.8155	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	707	236	E	V	gAa/gTa	6.14	1	0	probably_damaging	0.99	neutral	0.5	neutral	1.76	deleterious	-3.98	deleterious	-6.24	medium_impact	3.49	0.47	damaging	0.59	neutral	4.42	24.20	deleterious	0.03	0.35	0.37	neutral	0.91	disease	0.75	disease	0.79	disease	6	0.99	deleterious	0.26	neutral	1	deleterious	0.81	deleterious	-2.81	low_impact	0.19	medium_impact	1.95	medium_impact	0.23	0.8	73.56	11.71	0.59	P	0.90	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9914	9914	A	T	MI.8156	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	708	236	E	D	gaA/gaT	8.69	1	0	probably_damaging	0.92	neutral	0.2	neutral	1.83	neutral	-2.73	deleterious	-2.68	medium_impact	3.33	0.53	damaging	0.57	neutral	4.01	23.60	deleterious	0.2	0.45	0.3	neutral	0.81	disease	0.68	disease	0.71	disease	4	0.95	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-1.9	low_impact	-0.15	medium_impact	1.8	medium_impact	0.41	0.8	73.56	11.71	0.61	P	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9914	9914	A	C	MI.8157	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	708	236	E	D	gaA/gaC	8.69	1	0	probably_damaging	0.92	neutral	0.2	neutral	1.83	neutral	-2.73	deleterious	-2.68	medium_impact	3.33	0.53	damaging	0.57	neutral	3.88	23.50	deleterious	0.2	0.45	0.3	neutral	0.81	disease	0.68	disease	0.71	disease	4	0.95	neutral	0.14	neutral	1	deleterious	0.75	deleterious	-1.9	low_impact	-0.15	medium_impact	1.8	medium_impact	0.41	0.8	73.56	11.71	0.58	P	0.80	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9915	9915	G	A	MI.8158	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	709	237	A	T	Gcc/Acc	1.75	1	0	probably_damaging	1	neutral	0.42	neutral	2.41	neutral	-1.69	deleterious	-3.51	medium_impact	2.69	0.56	damaging	0.06	damaging	4.45	24.20	deleterious	0.11	0.4	0.23	neutral	0.76	disease	0.41	neutral	0.52	disease	0	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.11	medium_impact	1.23	medium_impact	0.56	0.8	73.95	11.92	0.38	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	COSM1155711	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9915	9915	G	T	MI.8159	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	709	237	A	S	Gcc/Tcc	1.75	1	0	probably_damaging	1	neutral	0.42	neutral	2.39	neutral	-2.08	deleterious	-2.6	medium_impact	2.88	0.54	damaging	0.08	damaging	3.83	23.40	deleterious	0.13	0.4	0.25	neutral	0.74	disease	0.39	neutral	0.52	disease	0	0.99	deleterious	0.21	neutral	1	deleterious	0.78	deleterious	-3.78	low_impact	0.11	medium_impact	1.4	medium_impact	0.33	0.8	73.95	11.92	0.36	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8909	8909	T	G	MI.816	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	383	128	F	C	tTc/tGc	0.36	0.04	0	possibly_damaging	0.53	deleterious	0	neutral	4.26	deleterious	-4.69	deleterious	-3.45	medium_impact	3.45	0.89	neutral	0.46	neutral	3.73	23.30	deleterious	0.29	0.65	0.87	disease	0.7	disease	0.69	disease	0.74	disease	5	1	deleterious	0.24	neutral	4	deleterious	0.58	deleterious	-0.81	medium_impact	-1.4	low_impact	1.86	medium_impact	0.30	0.9	19.91	15.56	0.41	N	0.81	polymorphism	0.99	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9915	9915	G	C	MI.8160	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	709	237	A	P	Gcc/Ccc	1.75	1	0	probably_damaging	1	neutral	0.2	neutral	2.36	deleterious	-3.08	deleterious	-4.42	high_impact	3.71	0.48	damaging	0.06	damaging	4.00	23.60	deleterious	0.03	0.35	0.33	neutral	0.85	disease	0.69	disease	0.74	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.15	medium_impact	2.14	high_impact	0.31	0.8	73.95	11.92	0.42	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9916	9916	C	T	MI.8161	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	710	237	A	V	gCc/gTc	9.15	1	0	probably_damaging	1	neutral	0.49	neutral	2.48	neutral	-0.83	deleterious	-3.54	medium_impact	2.38	0.48	damaging	0.06	damaging	4.54	24.30	deleterious	0.09	0.35	0.15	neutral	0.81	disease	0.55	disease	0.68	disease	4	0.99	deleterious	0.25	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	0.18	medium_impact	0.95	medium_impact	0.50	0.8	73.95	11.92	0.48	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9916	9916	C	A	MI.8162	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	710	237	A	D	gCc/gAc	9.15	1	0	probably_damaging	1	neutral	0.22	neutral	2.35	deleterious	-3.6	deleterious	-5.29	high_impact	4.41	0.57	damaging	0.06	damaging	4.74	24.70	deleterious	0.03	0.35	0.52	disease	0.9	disease	0.67	disease	0.76	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.12	medium_impact	2.77	high_impact	0.26	0.8	73.95	11.92	0.54	P	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9916	9916	C	G	MI.8163	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	710	237	A	G	gCc/gGc	9.15	1	0	probably_damaging	0.99	neutral	0.34	neutral	2.37	neutral	-2.54	deleterious	-3.53	medium_impact	2.84	0.53	damaging	0.11	damaging	4.11	23.70	deleterious	0.1	0.4	0.29	neutral	0.75	disease	0.54	disease	0.6	disease	2	0.99	deleterious	0.18	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	0.03	medium_impact	1.36	medium_impact	0.44	0.8	73.95	11.92	0.46	N	0.67	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9918	9918	G	T	MI.8164	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	712	238	A	S	Gcc/Tcc	-11.21	0	0	probably_damaging	1	neutral	0.39	neutral	2.01	neutral	-1.77	deleterious	-2.66	low_impact	1.73	0.43	damaging	0.17	damaging	3.85	23.40	deleterious	0.15	0.4	0.19	neutral	0.68	disease	0.37	neutral	0.43	neutral	1	1	deleterious	0.2	neutral	-2	neutral	0.77	deleterious	-3.78	low_impact	0.08	medium_impact	0.37	medium_impact	0.34	0.8	73.95	11.73	0.39	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9918	9918	G	A	MI.8165	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	712	238	A	T	Gcc/Acc	-11.21	0	0	probably_damaging	1	neutral	0.38	neutral	2	neutral	-1.88	deleterious	-3.55	medium_impact	2.51	0.6	damaging	0.06	damaging	4.38	24.10	deleterious	0.12	0.4	0.15	neutral	0.78	disease	0.65	disease	0.54	disease	1	1	deleterious	0.19	neutral	1	deleterious	0.77	deleterious	-3.78	low_impact	0.07	medium_impact	1.07	medium_impact	0.65	0.8	73.95	11.73	0.23	N	0.86	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9918	9918	G	C	MI.8166	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	712	238	A	P	Gcc/Ccc	-11.21	0	0	probably_damaging	1	neutral	0.2	neutral	1.89	deleterious	-4	deleterious	-4.44	high_impact	3.85	0.53	damaging	0.06	damaging	4.01	23.60	deleterious	0.03	0.35	0.52	disease	0.84	disease	0.78	disease	0.78	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.15	medium_impact	2.27	high_impact	0.31	0.8	73.95	11.73	0.37	N	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9919	9919	C	G	MI.8167	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	713	238	A	G	gCc/gGc	7.3	1	0	probably_damaging	0.99	neutral	0.34	neutral	1.99	neutral	-1.97	deleterious	-3.54	medium_impact	2.68	0.48	damaging	0.14	damaging	4.15	23.80	deleterious	0.12	0.4	0.31	neutral	0.72	disease	0.55	disease	0.52	disease	0	0.99	deleterious	0.18	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	0.03	medium_impact	1.22	medium_impact	0.42	0.8	73.95	11.73	0.49	N	0.67	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9919	9919	C	T	MI.8168	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	713	238	A	V	gCc/gTc	7.3	1	0	probably_damaging	1	neutral	0.49	neutral	1.93	neutral	-2.87	deleterious	-3.55	medium_impact	2.29	0.53	damaging	0.05	damaging	4.64	24.50	deleterious	0.1	0.4	0.17	neutral	0.83	disease	0.65	disease	0.71	disease	4	0.99	deleterious	0.25	neutral	1	deleterious	0.75	deleterious	-3.78	low_impact	0.18	medium_impact	0.87	medium_impact	0.56	0.8	73.95	11.73	0.45	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9919	9919	C	A	MI.8169	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	713	238	A	D	gCc/gAc	7.3	1	0	probably_damaging	1	neutral	0.2	neutral	1.89	deleterious	-4.06	deleterious	-5.32	high_impact	4.4	0.63	neutral	0.05	damaging	4.65	24.50	deleterious	0.03	0.35	0.45	neutral	0.9	disease	0.76	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.15	medium_impact	2.76	high_impact	0.26	0.8	73.95	11.73	0.58	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8909	8909	T	A	MI.817	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	383	128	F	Y	tTc/tAc	0.36	0.04	0	benign	0.11	deleterious	0	neutral	4.4	deleterious	-3.01	neutral	-1.64	medium_impact	2.64	0.89	neutral	0.48	neutral	2.41	18.89	deleterious	0.39	0.65	0.78	disease	0.49	neutral	0.67	disease	0.68	disease	4	1	deleterious	0.45	neutral	1	deleterious	0.31	neutral	0.11	medium_impact	-1.4	low_impact	1.17	medium_impact	0.61	0.9	19.91	15.56	0.42	N	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9921	9921	G	C	MI.8170	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	715	239	A	P	Gcc/Ccc	-9.59	0	0	possibly_damaging	0.8	neutral	0.2	neutral	2.14	deleterious	-3.42	deleterious	-4.19	high_impact	4.2	0.58	damaging	0.37	neutral	3.96	23.60	deleterious	0.03	0.35	0.52	disease	0.86	disease	0.79	disease	0.79	disease	6	0.88	neutral	0.2	neutral	1	deleterious	0.80	deleterious	-1.45	low_impact	-0.15	medium_impact	2.58	high_impact	0.41	0.8	75.1	11.16	0.48	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9921	9921	G	A	MI.8171	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	715	239	A	T	Gcc/Acc	-9.59	0	0	benign	0.02	neutral	0.39	neutral	2.2	neutral	-1.33	deleterious	-3.19	medium_impact	2.77	0.44	damaging	0.48	neutral	2.47	19.30	deleterious	0.08	0.35	0.28	neutral	0.8	disease	0.63	disease	0.65	disease	3	0.59	neutral	0.69	deleterious	-3	neutral	0.26	neutral	0.77	medium_impact	0.08	medium_impact	1.3	medium_impact	0.73	0.85	75.1	11.16	0.47	N	0.86	polymorphism	1	0.08	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9921	9921	G	T	MI.8172	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	715	239	A	S	Gcc/Tcc	-9.59	0	0	benign	0.34	neutral	0.4	neutral	2.18	neutral	-1.75	neutral	-2.47	low_impact	1.76	0.48	damaging	0.7	neutral	3.64	23.20	deleterious	0.15	0.4	0.13	neutral	0.74	disease	0.48	neutral	0.51	disease	0	0.53	neutral	0.53	deleterious	-6	neutral	0.31	neutral	-0.59	medium_impact	0.09	medium_impact	0.4	medium_impact	0.38	0.8	75.1	11.16	0.41	N	0.89	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9922	9922	C	G	MI.8173	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	716	239	A	G	gCc/gGc	4.29	1	0	benign	0.21	neutral	0.32	neutral	2.15	neutral	-2.68	deleterious	-3.42	medium_impact	2.67	0.61	neutral	0.55	neutral	3.91	23.50	deleterious	0.13	0.4	0.3	neutral	0.79	disease	0.68	disease	0.7	disease	4	0.62	neutral	0.56	deleterious	-3	neutral	0.32	neutral	-0.31	medium_impact	0.01	medium_impact	1.21	medium_impact	0.54	0.8	75.1	11.16	0.48	N	0.67	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9922	9922	C	T	MI.8174	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	716	239	A	V	gCc/gTc	4.29	1	0	benign	0.24	neutral	0.54	neutral	2.33	neutral	0.09	deleterious	-3.09	medium_impact	2.15	0.49	damaging	0.45	neutral	4.46	24.20	deleterious	0.07	0.35	0.24	neutral	0.81	disease	0.65	disease	0.55	disease	1	0.35	neutral	0.65	deleterious	-3	neutral	0.49	deleterious	-0.38	medium_impact	0.23	medium_impact	0.74	medium_impact	0.63	0.8	75.1	11.16	0.5	P	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9922	9922	C	A	MI.8175	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	716	239	A	D	gCc/gAc	4.29	1	0	possibly_damaging	0.68	neutral	0.2	neutral	2.14	deleterious	-3.2	deleterious	-5	high_impact	4.2	0.63	neutral	0.39	neutral	4.61	24.40	deleterious	0.03	0.35	0.45	neutral	0.91	disease	0.77	disease	0.81	disease	6	0.83	neutral	0.26	neutral	1	deleterious	0.73	deleterious	-1.19	low_impact	-0.15	medium_impact	2.58	high_impact	0.41	0.8	75.1	11.16	0.62	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9924	9924	T	C	MI.8176	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	718	240	W	R	Tga/Cga	-7.97	0	0	probably_damaging	1	neutral	0.09	neutral	2.16	neutral	-2.76	deleterious	-12.07	high_impact	3.88	0.59	damaging	0.05	damaging	3.66	23.20	deleterious	0.03	0.35	0.37	neutral	0.9	disease	0.76	disease	0.81	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.38	medium_impact	2.3	high_impact	0.17	0.8	73.56	11.87	0.41	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9924	9924	T	G	MI.8177	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	718	240	W	G	Tga/Gga	-7.97	0	0	probably_damaging	0.99	neutral	0.09	neutral	2.15	neutral	-2.9	deleterious	-11.21	high_impact	3.54	0.6	neutral	0.02	damaging	4.04	23.70	deleterious	0.05	0.35	0.39	neutral	0.85	disease	0.72	disease	0.77	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.78	deleterious	-2.81	low_impact	-0.38	medium_impact	1.99	medium_impact	0.12	0.8	73.56	11.87	0.3	N	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9925	9925	G	T	MI.8178	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	719	240	W	L	tGa/tTa	7.3	1	0	probably_damaging	0.99	neutral	0.17	neutral	2.41	neutral	1.42	deleterious	-11.21	medium_impact	2.09	0.51	damaging	0.02	damaging	4.44	24.20	deleterious	0.09	0.35	0.17	neutral	0.78	disease	0.57	disease	0.5	disease	0	0.99	deleterious	0.09	neutral	1	deleterious	0.72	deleterious	-2.81	low_impact	-0.2	medium_impact	0.69	medium_impact	0.13	0.8	73.56	11.87	0.38	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9925	9925	G	C	MI.8179	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	719	240	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.14	neutral	2.18	neutral	-1.73	deleterious	-12.07	high_impact	4.43	0.67	neutral	0.02	damaging	4.23	23.90	deleterious	0.05	0.35	0.26	neutral	0.89	disease	0.71	disease	0.78	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.26	medium_impact	2.79	high_impact	0.15	0.8	73.56	11.87	0.47	N	0.97	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8910	8910	C	G	MI.818	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	384	128	F	L	ttC/ttG	7.53	0.97	0	benign	0	neutral	1	neutral	4.64	neutral	-0.75	neutral	0.09	neutral_impact	-0.74	0.93	neutral	0.95	neutral	-0.25	0.85	neutral	0.44	0.65	0.26	neutral	0.12	neutral	0.24	neutral	0.29	neutral	4	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.98	high_impact	-1.73	low_impact	0.73	0.9	19.91	15.56	0.5	N	0.07	polymorphism	0.96	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9926	9926	A	T	MI.8180	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	720	240	W	C	tgA/tgT	9.15	1	0	probably_damaging	1	neutral	0.11	neutral	2.14	deleterious	-3.05	deleterious	-11.21	high_impact	4.43	0.67	neutral	0.02	damaging	4.22	23.90	deleterious	0.04	0.35	0.44	neutral	0.9	disease	0.74	disease	0.8	disease	6	1	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.33	medium_impact	2.79	high_impact	0.19	0.8	73.56	11.87	0.52	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9926	9926	A	C	MI.8181	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	720	240	W	C	tgA/tgC	9.15	1	0	probably_damaging	1	neutral	0.11	neutral	2.14	deleterious	-3.05	deleterious	-11.21	high_impact	4.43	0.67	neutral	0.02	damaging	4.11	23.80	deleterious	0.04	0.35	0.44	neutral	0.9	disease	0.74	disease	0.8	disease	6	1	deleterious	0.06	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.33	medium_impact	2.79	high_impact	0.19	0.8	73.56	11.87	0.52	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9927	9927	T	G	MI.8182	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	721	241	Y	D	Tac/Gac	3.83	1	0	probably_damaging	1	deleterious	0.04	neutral	1.08	deleterious	-9.99	deleterious	-8.62	high_impact	4.3	0.6	neutral	0.01	damaging	4.09	23.70	deleterious	0.02	0.35	0.88	disease	0.84	disease	0.82	disease	0.87	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.78	low_impact	-0.6	medium_impact	2.67	high_impact	0.15	0.8	73.95	11.49	0.47	N	0.99	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9927	9927	T	C	MI.8183	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	721	241	Y	H	Tac/Cac	3.83	1	0	probably_damaging	1	neutral	0.54	neutral	1.1	deleterious	-7.43	deleterious	-4.31	high_impact	4.11	0.56	damaging	0.02	damaging	3.72	23.30	deleterious	0.05	0.35	0.7	disease	0.78	disease	0.8	disease	0.79	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	0.23	medium_impact	2.5	high_impact	0.19	0.8	73.95	11.49	0.5	N	0.97	polymorphism	1	0.42	.	.	.	.	.	.	COSM1155713	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9927	9927	T	A	MI.8184	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	721	241	Y	N	Tac/Aac	3.83	1	0	probably_damaging	1	neutral	0.07	neutral	1.08	deleterious	-8.78	deleterious	-7.76	high_impact	4.66	0.59	damaging	0.01	damaging	4.17	23.80	deleterious	0.02	0.35	0.81	disease	0.86	disease	0.77	disease	0.82	disease	6	1	deleterious	0.04	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.45	medium_impact	2.99	high_impact	0.15	0.8	73.95	11.49	0.54	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9928	9928	A	G	MI.8185	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	722	241	Y	C	tAc/tGc	7.3	1	0	probably_damaging	1	deleterious	0.04	neutral	1.08	deleterious	-10.17	deleterious	-7.76	high_impact	4.66	0.64	neutral	0.01	damaging	3.51	23.10	deleterious	0.02	0.35	0.89	disease	0.85	disease	0.79	disease	0.86	disease	7	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-3.78	low_impact	-0.6	medium_impact	2.99	high_impact	0.15	0.8	73.95	11.49	0.55	P	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9928	9928	A	C	MI.8186	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	722	241	Y	S	tAc/tCc	7.3	1	0	probably_damaging	1	neutral	0.09	neutral	1.08	deleterious	-8.53	deleterious	-7.76	high_impact	4.66	0.61	neutral	0.02	damaging	3.71	23.30	deleterious	0.02	0.35	0.75	disease	0.8	disease	0.76	disease	0.78	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.38	medium_impact	2.99	high_impact	0.15	0.8	73.95	11.49	0.55	P	0.96	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9928	9928	A	T	MI.8187	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	722	241	Y	F	tAc/tTc	7.3	1	0	probably_damaging	0.99	neutral	0.42	neutral	1.39	deleterious	-3.93	deleterious	-3.45	medium_impact	2.9	0.58	damaging	0.02	damaging	3.38	23.00	deleterious	0.11	0.4	0.31	neutral	0.81	disease	0.72	disease	0.74	disease	5	0.99	deleterious	0.22	neutral	1	deleterious	0.78	deleterious	-2.81	low_impact	0.11	medium_impact	1.42	medium_impact	0.55	0.8	73.95	11.49	0.44	N	0.72	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9930	9930	T	C	MI.8188	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	724	242	W	R	Tgg/Cgg	-1.49	0	0	probably_damaging	1	neutral	0.11	neutral	-0.75	deleterious	-10.24	deleterious	-12.07	high_impact	3.98	0.66	neutral	0.03	damaging	3.74	23.30	deleterious	0.02	0.35	0.64	disease	0.93	disease	0.8	disease	0.86	disease	7	1	deleterious	0.06	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.33	medium_impact	2.38	high_impact	0.17	0.8	73.95	11.58	0.37	N	0.99	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9930	9930	T	G	MI.8189	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	724	242	W	G	Tgg/Ggg	-1.49	0	0	probably_damaging	1	neutral	0.19	neutral	-0.76	deleterious	-11.81	deleterious	-11.21	high_impact	4.33	0.61	neutral	0.02	damaging	4.02	23.60	deleterious	0.03	0.35	0.65	disease	0.88	disease	0.78	disease	0.82	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.17	medium_impact	2.7	high_impact	0.12	0.8	73.95	11.58	0.36	N	0.98	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8910	8910	C	A	MI.819	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	384	128	F	L	ttC/ttA	7.53	0.97	0	benign	0	neutral	1	neutral	4.64	neutral	-0.75	neutral	0.09	neutral_impact	-0.74	0.93	neutral	0.95	neutral	0.05	3.06	deleterious	0.44	0.65	0.26	neutral	0.12	neutral	0.24	neutral	0.29	neutral	4	0	neutral	1	deleterious	-6	neutral	0.12	neutral	2.09	high_impact	1.98	high_impact	-1.73	low_impact	0.73	0.9	19.91	15.56	0.51	N	0.07	polymorphism	0.96	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9931	9931	G	C	MI.8190	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	725	242	W	S	tGg/tCg	7.3	1	0	probably_damaging	1	neutral	0.13	neutral	-0.76	deleterious	-11.8	deleterious	-12.07	high_impact	4.33	0.65	neutral	0.02	damaging	4.15	23.80	deleterious	0.02	0.35	0.52	disease	0.91	disease	0.76	disease	0.81	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.84	deleterious	-3.78	low_impact	-0.28	medium_impact	2.7	high_impact	0.13	0.8	73.95	11.58	0.41	N	0.97	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9931	9931	G	T	MI.8191	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	725	242	W	L	tGg/tTg	7.3	1	0	probably_damaging	1	neutral	0.21	neutral	-0.75	deleterious	-9.37	deleterious	-11.21	high_impact	3.63	0.61	neutral	0.02	damaging	4.39	24.10	deleterious	0.03	0.35	0.37	neutral	0.87	disease	0.76	disease	0.77	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.14	medium_impact	2.07	high_impact	0.10	0.8	73.95	11.58	0.41	N	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9932	9932	G	T	MI.8192	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	726	242	W	C	tgG/tgT	6.14	1	0.03	probably_damaging	1	neutral	0.06	neutral	-0.76	deleterious	-12.02	deleterious	-11.21	high_impact	4.33	0.66	neutral	0.02	damaging	4.29	24.00	deleterious	0.03	0.35	0.77	disease	0.92	disease	0.79	disease	0.82	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.49	medium_impact	2.7	high_impact	0.13	0.8	73.95	11.58	0.42	N	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9932	9932	G	C	MI.8193	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	726	242	W	C	tgG/tgC	6.14	1	0.03	probably_damaging	1	neutral	0.06	neutral	-0.76	deleterious	-12.02	deleterious	-11.21	high_impact	4.33	0.66	neutral	0.02	damaging	4.14	23.80	deleterious	0.03	0.35	0.77	disease	0.92	disease	0.79	disease	0.82	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	-0.49	medium_impact	2.7	high_impact	0.13	0.8	73.95	11.58	0.43	N	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9933	9933	C	T	MI.8194	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	727	243	H	Y	Cat/Tat	3.14	1	0	probably_damaging	0.96	neutral	1	neutral	1.21	deleterious	-4.58	deleterious	-5.16	high_impact	4.66	0.66	neutral	0.02	damaging	3.91	23.50	deleterious	0.06	0.35	0.6	disease	0.91	disease	0.75	disease	0.82	disease	6	0.96	neutral	0.52	deleterious	2	deleterious	0.84	deleterious	-2.21	low_impact	1.9	high_impact	2.99	high_impact	0.29	0.8	73.56	11.37	0.5	N	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9933	9933	C	A	MI.8195	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	727	243	H	N	Cat/Aat	3.14	1	0	probably_damaging	0.98	neutral	0.25	neutral	1.13	deleterious	-6.43	deleterious	-6.02	high_impact	4.66	0.62	neutral	0.02	damaging	4.06	23.70	deleterious	0.11	0.4	0.66	disease	0.89	disease	0.74	disease	0.8	disease	6	0.98	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-2.51	low_impact	-0.08	medium_impact	2.99	high_impact	0.26	0.8	73.56	11.37	0.53	P	0.96	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9933	9933	C	G	MI.8196	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	727	243	H	D	Cat/Gat	3.14	1	0	probably_damaging	0.98	neutral	0.31	neutral	1.13	deleterious	-6.89	deleterious	-7.73	high_impact	3.96	0.64	neutral	0.01	damaging	4.00	23.60	deleterious	0.05	0.35	0.66	disease	0.86	disease	0.8	disease	0.83	disease	7	0.99	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-2.51	low_impact	-0.01	medium_impact	2.37	high_impact	0.19	0.8	73.56	11.37	0.46	N	0.98	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9934	9934	A	C	MI.8197	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	728	243	H	P	cAt/cCt	4.29	1	0	probably_damaging	0.99	neutral	0.17	neutral	1.11	deleterious	-8.12	deleterious	-8.6	high_impact	4.66	0.62	neutral	0.02	damaging	3.41	23.00	deleterious	0.03	0.35	0.78	disease	0.89	disease	0.82	disease	0.86	disease	7	0.99	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-2.81	low_impact	-0.2	medium_impact	2.99	high_impact	0.20	0.8	73.56	11.37	0.54	P	0.98	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9934	9934	A	T	MI.8198	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	728	243	H	L	cAt/cTt	4.29	1	0	probably_damaging	0.97	neutral	0.61	neutral	1.13	deleterious	-6.59	deleterious	-9.46	high_impact	3.76	0.59	damaging	0.02	damaging	4.02	23.60	deleterious	0.04	0.35	0.56	disease	0.92	disease	0.75	disease	0.82	disease	6	0.96	neutral	0.32	neutral	2	deleterious	0.83	deleterious	-2.34	low_impact	0.3	medium_impact	2.19	high_impact	0.25	0.8	73.56	11.37	0.45	N	0.96	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9934	9934	A	G	MI.8199	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	728	243	H	R	cAt/cGt	4.29	1	0	probably_damaging	0.97	neutral	0.33	neutral	1.14	deleterious	-5.97	deleterious	-6.88	high_impact	4.31	0.73	neutral	0.02	damaging	3.17	22.70	deleterious	0.05	0.35	0.59	disease	0.9	disease	0.78	disease	0.82	disease	6	0.97	neutral	0.18	neutral	2	deleterious	0.85	deleterious	-2.34	low_impact	0.02	medium_impact	2.68	high_impact	0.40	0.8	73.56	11.37	0.5	N	0.99	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8563	8563	A	T	MI.82	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	37	13	T	S	Aca/Tca	-8.89	0	0.12	probably_damaging	0.99	neutral	0.54	neutral	4.61	neutral	-0.58	neutral	-1.82	low_impact	0.94	0.88	neutral	0.96	neutral	1.76	14.75	neutral	0.5	0.65	0.24	neutral	0.37	neutral	0.39	neutral	0.44	neutral	1	0.99	deleterious	0.28	neutral	-2	neutral	0.64	deleterious	-2.65	low_impact	0.33	medium_impact	-0.29	medium_impact	0.73	0.9	15.49	16.77	0.35	N	0.37	polymorphism	1	0.03	rs386829041	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8911	8911	T	G	MI.820	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	385	129	L	V	Tta/Gta	-9.59	0	0	probably_damaging	0.99	neutral	0.68	neutral	4.41	neutral	0.64	deleterious	-2.76	low_impact	1.5	0.72	neutral	0.15	damaging	3.42	23.00	deleterious	0.49	0.65	0.31	neutral	0.25	neutral	0.31	neutral	0.43	neutral	1	0.99	deleterious	0.35	neutral	-2	neutral	0.72	deleterious	-2.65	low_impact	0.48	medium_impact	0.19	medium_impact	0.54	0.9	49.12	8.65	0.24	N	0.87	polymorphism	0.96	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9935	9935	T	G	MI.8200	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	729	243	H	Q	caT/caG	8.69	1	0	probably_damaging	0.98	neutral	0.24	neutral	1.14	deleterious	-6.26	deleterious	-6.88	high_impact	4.66	0.65	neutral	0.02	damaging	3.60	23.20	deleterious	0.06	0.35	0.65	disease	0.81	disease	0.75	disease	0.78	disease	6	0.99	deleterious	0.13	neutral	2	deleterious	0.80	deleterious	-2.51	low_impact	-0.09	medium_impact	2.99	high_impact	0.37	0.8	73.56	11.37	0.6	P	0.94	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9935	9935	T	A	MI.8201	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	729	243	H	Q	caT/caA	8.69	1	0	probably_damaging	0.98	neutral	0.24	neutral	1.14	deleterious	-6.26	deleterious	-6.88	high_impact	4.66	0.65	neutral	0.02	damaging	3.72	23.30	deleterious	0.06	0.35	0.65	disease	0.81	disease	0.75	disease	0.78	disease	6	0.99	deleterious	0.13	neutral	2	deleterious	0.80	deleterious	-2.51	low_impact	-0.09	medium_impact	2.99	high_impact	0.37	0.8	73.56	11.37	0.61	P	0.94	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9936	9936	T	C	MI.8202	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	730	244	F	L	Ttt/Ctt	-1.72	0	0	probably_damaging	0.98	neutral	0.58	neutral	1.61	deleterious	-3.03	deleterious	-5.17	high_impact	3.51	0.65	neutral	0.03	damaging	4.33	24.00	deleterious	0.03	0.35	0.36	neutral	0.83	disease	0.61	disease	0.71	disease	4	0.98	deleterious	0.3	neutral	2	deleterious	0.75	deleterious	-2.51	low_impact	0.27	medium_impact	1.96	medium_impact	0.43	0.8	73.56	11.67	0.23	N	0.92	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9936	9936	T	A	MI.8203	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	730	244	F	I	Ttt/Att	-1.72	0	0	probably_damaging	0.99	neutral	0.31	neutral	1.48	deleterious	-4.56	deleterious	-5.17	high_impact	4.12	0.68	neutral	0.02	damaging	4.79	24.70	deleterious	0.05	0.35	0.43	neutral	0.87	disease	0.6	disease	0.73	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.80	deleterious	-2.81	low_impact	-0.01	medium_impact	2.51	high_impact	0.45	0.8	73.56	11.67	0.34	N	0.96	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9936	9936	T	G	MI.8204	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	730	244	F	V	Ttt/Gtt	-1.72	0	0	probably_damaging	1	neutral	0.8	neutral	1.48	deleterious	-4.56	deleterious	-6.03	medium_impact	3.08	0.59	damaging	0.02	damaging	4.26	23.90	deleterious	0.04	0.35	0.28	neutral	0.84	disease	0.61	disease	0.54	disease	1	1	deleterious	0.4	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	0.54	medium_impact	1.58	medium_impact	0.38	0.8	73.56	11.67	0.2	N	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9937	9937	T	C	MI.8205	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	731	244	F	S	tTt/tCt	5.68	1	0	probably_damaging	1	neutral	0.27	neutral	1.41	deleterious	-7.37	deleterious	-6.89	high_impact	4.32	0.7	neutral	0.03	damaging	4.33	24.00	deleterious	0.03	0.35	0.52	disease	0.84	disease	0.63	disease	0.73	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.06	medium_impact	2.69	high_impact	0.19	0.8	73.56	11.67	0.47	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9937	9937	T	G	MI.8206	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	731	244	F	C	tTt/tGt	5.68	1	0	probably_damaging	1	neutral	0.12	neutral	1.41	deleterious	-7.98	deleterious	-6.89	high_impact	4.66	0.72	neutral	0.02	damaging	4.20	23.90	deleterious	0.02	0.35	0.76	disease	0.87	disease	0.66	disease	0.74	disease	5	1	deleterious	0.06	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.3	medium_impact	2.99	high_impact	0.21	0.8	73.56	11.67	0.52	P	0.98	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9937	9937	T	A	MI.8207	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	731	244	F	Y	tTt/tAt	5.68	1	0	probably_damaging	0.98	neutral	0.78	neutral	1.44	deleterious	-5.43	deleterious	-2.58	high_impact	4.32	0.71	neutral	0.03	damaging	4.25	23.90	deleterious	0.09	0.35	0.5	disease	0.82	disease	0.62	disease	0.71	disease	4	0.98	deleterious	0.4	neutral	2	deleterious	0.79	deleterious	-2.51	low_impact	0.51	medium_impact	2.69	high_impact	0.49	0.8	73.56	11.67	0.5	N	0.80	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9938	9938	T	G	MI.8208	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	732	244	F	L	ttT/ttG	7.3	1	0.01	probably_damaging	0.98	neutral	0.58	neutral	1.61	deleterious	-3.03	deleterious	-5.17	high_impact	3.51	0.65	neutral	0.03	damaging	4.48	24.20	deleterious	0.03	0.35	0.36	neutral	0.83	disease	0.61	disease	0.71	disease	4	0.98	deleterious	0.3	neutral	2	deleterious	0.75	deleterious	-2.51	low_impact	0.27	medium_impact	1.96	medium_impact	0.43	0.8	73.56	11.67	0.44	N	0.92	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9938	9938	T	A	MI.8209	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	732	244	F	L	ttT/ttA	7.3	1	0.01	probably_damaging	0.98	neutral	0.58	neutral	1.61	deleterious	-3.03	deleterious	-5.17	high_impact	3.51	0.65	neutral	0.03	damaging	4.58	24.40	deleterious	0.03	0.35	0.36	neutral	0.83	disease	0.61	disease	0.71	disease	4	0.98	deleterious	0.3	neutral	2	deleterious	0.75	deleterious	-2.51	low_impact	0.27	medium_impact	1.96	medium_impact	0.43	0.8	73.56	11.67	0.45	N	0.92	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8911	8911	T	A	MI.821	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	385	129	L	M	Tta/Ata	-9.59	0	0	probably_damaging	1	neutral	0.13	neutral	4.13	neutral	-1.37	neutral	-1.84	medium_impact	2.56	0.78	neutral	0.16	damaging	3.56	23.10	deleterious	0.36	0.65	0.69	disease	0.49	neutral	0.68	disease	0.59	disease	2	1	deleterious	0.07	neutral	1	deleterious	0.77	deleterious	-3.6	low_impact	-0.18	medium_impact	1.1	medium_impact	0.67	0.9	49.12	8.65	0.31	N	0.96	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9939	9939	G	T	MI.8210	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	733	245	V	L	Gta/Tta	-5.89	0	0	probably_damaging	0.92	neutral	0.67	neutral	1.89	neutral	-2.88	deleterious	-2.58	medium_impact	3.29	0.61	neutral	0.02	damaging	3.81	23.40	deleterious	0.11	0.4	0.27	neutral	0.8	disease	0.66	disease	0.54	disease	1	0.91	neutral	0.38	neutral	1	deleterious	0.75	deleterious	-1.9	low_impact	0.37	medium_impact	1.77	medium_impact	0.24	0.8	73.95	11.87	0.2	N	0.68	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9939	9939	G	C	MI.8211	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	733	245	V	L	Gta/Cta	-5.89	0	0	probably_damaging	0.92	neutral	0.67	neutral	1.89	neutral	-2.88	deleterious	-2.58	medium_impact	3.29	0.61	neutral	0.02	damaging	3.65	23.20	deleterious	0.11	0.4	0.27	neutral	0.8	disease	0.66	disease	0.54	disease	1	0.91	neutral	0.38	neutral	1	deleterious	0.75	deleterious	-1.9	low_impact	0.37	medium_impact	1.77	medium_impact	0.24	0.8	73.95	11.87	0.2	N	0.68	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9939	9939	G	A	MI.8212	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	733	245	V	M	Gta/Ata	-5.89	0	0	probably_damaging	1	neutral	0.22	neutral	1.58	deleterious	-5.28	deleterious	-2.58	high_impact	4.64	0.65	neutral	0.01	damaging	3.81	23.40	deleterious	0.07	0.35	0.63	disease	0.75	disease	0.73	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	-0.12	medium_impact	2.98	high_impact	0.51	0.8	73.95	11.87	0.49	N	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9940	9940	T	C	MI.8213	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	734	245	V	A	gTa/gCa	9.15	1	0	probably_damaging	0.99	neutral	0.54	neutral	1.63	deleterious	-5.53	deleterious	-3.44	high_impact	4.29	0.61	neutral	0.05	damaging	3.68	23.30	deleterious	0.05	0.35	0.56	disease	0.76	disease	0.72	disease	0.74	disease	5	0.99	deleterious	0.28	neutral	2	deleterious	0.80	deleterious	-2.81	low_impact	0.23	medium_impact	2.66	high_impact	0.12	0.8	73.95	11.87	0.54	P	0.39	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9940	9940	T	A	MI.8214	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	734	245	V	E	gTa/gAa	9.15	1	0	probably_damaging	0.99	neutral	0.26	neutral	1.56	deleterious	-7.65	deleterious	-5.16	high_impact	3.94	0.67	neutral	0.04	damaging	4.72	24.60	deleterious	0.02	0.35	0.83	disease	0.89	disease	0.77	disease	0.84	disease	7	1	deleterious	0.14	neutral	2	deleterious	0.88	deleterious	-2.81	low_impact	-0.07	medium_impact	2.35	high_impact	0.14	0.8	73.95	11.87	0.57	P	0.96	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9940	9940	T	G	MI.8215	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	734	245	V	G	gTa/gGa	9.15	1	0	probably_damaging	1	neutral	0.31	neutral	1.56	deleterious	-7.59	deleterious	-6.02	high_impact	4.09	0.57	damaging	0.05	damaging	3.96	23.60	deleterious	0.02	0.35	0.83	disease	0.84	disease	0.71	disease	0.78	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	-0.01	medium_impact	2.48	high_impact	0.15	0.8	73.95	11.87	0.48	N	0.88	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9942	9942	G	A	MI.8216	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	736	246	D	N	Gat/Aat	-0.1	0.73	0	probably_damaging	0.99	neutral	0.31	neutral	1.43	deleterious	-5.62	deleterious	-4.3	high_impact	3.96	0.55	damaging	0.02	damaging	4.31	24.00	deleterious	0.27	0.45	0.47	neutral	0.89	disease	0.67	disease	0.74	disease	5	0.99	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-2.81	low_impact	-0.01	medium_impact	2.37	high_impact	0.80	0.85	73.56	12.71	0.35	N	0.96	polymorphism	1	0.47	rs28715301	.	.	.	.	endometrial tumor	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9942	9942	G	C	MI.8217	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	736	246	D	H	Gat/Cat	-0.1	0.73	0	probably_damaging	1	neutral	0.56	neutral	1.41	deleterious	-7.09	deleterious	-6.02	high_impact	4.66	0.58	damaging	0.01	damaging	3.76	23.30	deleterious	0.05	0.35	0.7	disease	0.89	disease	0.79	disease	0.82	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	0.25	medium_impact	2.99	high_impact	0.33	0.8	73.56	12.71	0.51	N	0.99	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9942	9942	G	T	MI.8218	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	736	246	D	Y	Gat/Tat	-0.1	0.73	0	probably_damaging	1	neutral	1	neutral	1.41	deleterious	-7.57	deleterious	-7.74	high_impact	4.66	0.6	neutral	0.01	damaging	4.05	23.70	deleterious	0.03	0.35	0.81	disease	0.96	disease	0.72	disease	0.85	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.89	deleterious	-3.78	low_impact	1.9	high_impact	2.99	high_impact	0.15	0.8	73.56	12.71	0.43	N	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9943	9943	A	C	MI.8219	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	737	246	D	A	gAt/gCt	7.3	1	0	probably_damaging	1	neutral	0.51	neutral	1.44	deleterious	-5.48	deleterious	-6.88	high_impact	4.66	0.6	damaging	0.02	damaging	3.81	23.40	deleterious	0.05	0.35	0.53	disease	0.9	disease	0.72	disease	0.78	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.2	medium_impact	2.99	high_impact	0.30	0.8	73.56	12.71	0.55	P	0.83	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8912	8912	T	G	MI.822	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	386	129	L	W	tTa/tGa	-0.33	0	0	probably_damaging	1	neutral	0.09	neutral	4.07	neutral	-2.73	deleterious	-5.54	high_impact	4.14	0.78	neutral	0.13	damaging	3.82	23.40	deleterious	0.17	0.65	0.92	disease	0.71	disease	0.72	disease	0.79	disease	6	1	deleterious	0.05	neutral	2	deleterious	0.86	deleterious	-3.6	low_impact	-0.28	medium_impact	2.45	high_impact	0.55	0.9	49.12	8.65	0.29	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9943	9943	A	G	MI.8220	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	737	246	D	G	gAt/gGt	7.3	1	0	probably_damaging	1	neutral	0.33	neutral	1.43	deleterious	-5.87	deleterious	-6.02	high_impact	4.11	0.58	damaging	0.01	damaging	4.04	23.70	deleterious	0.06	0.35	0.59	disease	0.89	disease	0.71	disease	0.77	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	0.02	medium_impact	2.5	high_impact	0.24	0.8	73.56	12.71	0.48	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9943	9943	A	T	MI.8221	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	737	246	D	V	gAt/gTt	7.3	1	0	probably_damaging	1	neutral	0.68	neutral	1.43	deleterious	-5.91	deleterious	-7.74	high_impact	4.3	0.56	damaging	0.01	damaging	3.80	23.40	deleterious	0.03	0.35	0.72	disease	0.94	disease	0.73	disease	0.86	disease	7	1	deleterious	0.34	neutral	2	deleterious	0.86	deleterious	-3.78	low_impact	0.38	medium_impact	2.67	high_impact	0.11	0.8	73.56	12.71	0.49	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9944	9944	T	A	MI.8222	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	738	246	D	E	gaT/gaA	6.84	1	0	probably_damaging	0.97	neutral	0.29	neutral	1.6	deleterious	-3.06	deleterious	-3.44	high_impact	4.11	0.62	neutral	0.02	damaging	4.18	23.80	deleterious	0.17	0.45	0.28	neutral	0.85	disease	0.67	disease	0.74	disease	5	0.98	neutral	0.16	neutral	2	deleterious	0.76	deleterious	-2.34	low_impact	-0.03	medium_impact	2.5	high_impact	0.44	0.8	73.56	12.71	0.55	P	0.93	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9944	9944	T	G	MI.8223	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	738	246	D	E	gaT/gaG	6.84	1	0	probably_damaging	0.97	neutral	0.29	neutral	1.6	deleterious	-3.06	deleterious	-3.44	high_impact	4.11	0.62	neutral	0.02	damaging	4.00	23.60	deleterious	0.17	0.45	0.28	neutral	0.85	disease	0.67	disease	0.74	disease	5	0.98	neutral	0.16	neutral	2	deleterious	0.76	deleterious	-2.34	low_impact	-0.03	medium_impact	2.5	high_impact	0.44	0.8	73.56	12.71	0.53	P	0.93	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9945	9945	G	C	MI.8224	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	739	247	V	L	Gtg/Ctg	-1.72	0	0	possibly_damaging	0.85	neutral	0.37	neutral	1.8	neutral	-2.08	neutral	-2.3	medium_impact	3	0.57	damaging	0.03	damaging	1.75	14.71	neutral	0.25	0.45	0.24	neutral	0.84	disease	0.47	neutral	0.67	disease	3	0.86	neutral	0.26	neutral	0	NA	0.61	deleterious	-1.6	low_impact	0.06	medium_impact	1.51	medium_impact	0.30	0.8	72.8	11.58	0.25	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9945	9945	G	T	MI.8225	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	739	247	V	L	Gtg/Ttg	-1.72	0	0	possibly_damaging	0.85	neutral	0.37	neutral	1.8	neutral	-2.08	neutral	-2.3	medium_impact	3	0.57	damaging	0.03	damaging	1.88	15.48	deleterious	0.25	0.45	0.24	neutral	0.84	disease	0.47	neutral	0.67	disease	3	0.86	neutral	0.26	neutral	0	NA	0.61	deleterious	-1.6	low_impact	0.06	medium_impact	1.51	medium_impact	0.30	0.8	72.8	11.58	0.25	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9945	9945	G	A	MI.8226	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	739	247	V	M	Gtg/Atg	-1.72	0	0	probably_damaging	0.99	neutral	0.06	neutral	1.64	deleterious	-4.27	neutral	-2.29	high_impact	3.52	0.61	neutral	0.04	damaging	3.59	23.20	deleterious	0.17	0.45	0.57	disease	0.75	disease	0.54	disease	0.59	disease	2	1	deleterious	0.04	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	-0.49	medium_impact	1.97	medium_impact	0.55	0.8	72.8	11.58	0.27	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9946	9946	T	G	MI.8227	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	740	247	V	G	gTg/gGg	4.29	1	0	probably_damaging	0.99	deleterious	0.02	neutral	1.61	deleterious	-5.68	deleterious	-5.9	medium_impact	3.11	0.57	damaging	0.05	damaging	3.84	23.40	deleterious	0.03	0.35	0.82	disease	0.86	disease	0.59	disease	0.74	disease	5	1	deleterious	0.02	neutral	5	deleterious	0.83	deleterious	-2.81	low_impact	-0.77	medium_impact	1.61	medium_impact	0.21	0.8	72.8	11.58	0.32	N	0.88	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9946	9946	T	C	MI.8228	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	740	247	V	A	gTg/gCg	4.29	1	0	probably_damaging	0.98	deleterious	0.04	neutral	1.66	deleterious	-3.8	deleterious	-3.35	medium_impact	3.35	0.59	damaging	0.04	damaging	2.11	16.94	deleterious	0.13	0.4	0.55	disease	0.79	disease	0.58	disease	0.69	disease	4	1	deleterious	0.03	neutral	5	deleterious	0.78	deleterious	-2.51	low_impact	-0.6	medium_impact	1.82	medium_impact	0.09	0.8	72.8	11.58	0.38	N	0.39	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9946	9946	T	A	MI.8229	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	740	247	V	E	gTg/gAg	4.29	1	0	probably_damaging	0.99	deleterious	0.01	neutral	1.62	deleterious	-5.46	deleterious	-5.04	high_impact	4.5	0.65	neutral	0.03	damaging	4.54	24.30	deleterious	0.02	0.35	0.82	disease	0.91	disease	0.68	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.81	low_impact	-0.95	medium_impact	2.85	high_impact	0.13	0.8	72.8	11.58	0.46	N	0.96	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8912	8912	T	C	MI.823	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	386	129	L	S	tTa/tCa	-0.33	0	0	probably_damaging	1	neutral	0.13	neutral	4.11	neutral	-2.32	deleterious	-5.5	high_impact	3.8	0.88	neutral	0.17	damaging	3.79	23.40	deleterious	0.26	0.65	0.72	disease	0.74	disease	0.69	disease	0.69	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.83	deleterious	-3.6	low_impact	-0.18	medium_impact	2.16	high_impact	0.68	0.9	49.12	8.65	0.35	N	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9948	9948	G	C	MI.8230	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	742	248	V	L	Gtt/Ctt	-9.59	0	0.01	benign	0.06	neutral	0.52	neutral	1.69	deleterious	-3.19	deleterious	-2.54	high_impact	4.56	0.63	neutral	0.56	neutral	1.86	15.33	deleterious	0.1	0.4	0.26	neutral	0.86	disease	0.63	disease	0.74	disease	5	0.42	neutral	0.73	deleterious	-2	neutral	0.25	neutral	0.29	medium_impact	0.21	medium_impact	2.9	high_impact	0.27	0.8	75.1	10.79	0.47	N	0.71	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9948	9948	G	A	MI.8231	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	742	248	V	I	Gtt/Att	-9.59	0	0.01	benign	0.01	neutral	0.31	neutral	1.93	neutral	-2.26	neutral	-0.84	low_impact	1.73	0.61	neutral	0.64	neutral	0.74	9.11	deleterious	0.21	0.45	0.2	neutral	0.61	disease	0.57	disease	0.43	neutral	1	0.68	neutral	0.65	deleterious	-6	neutral	0.19	neutral	1.07	medium_impact	-0.01	medium_impact	0.37	medium_impact	0.51	0.8	75.1	10.79	0.38	N	0.06	polymorphism	1	0.03	.	.	.	.	.	papillary thyroid carcinoma	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9948	9948	G	T	MI.8232	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	742	248	V	F	Gtt/Ttt	-9.59	0	0.01	possibly_damaging	0.78	neutral	0.4	neutral	1.59	deleterious	-6.22	deleterious	-4.25	high_impact	4.56	0.58	damaging	0.51	neutral	3.92	23.50	deleterious	0.03	0.35	0.51	disease	0.94	disease	0.69	disease	0.82	disease	6	0.79	neutral	0.31	neutral	1	deleterious	0.74	deleterious	-1.4	low_impact	0.09	medium_impact	2.9	high_impact	0.17	0.8	75.1	10.79	0.45	N	0.97	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9949	9949	T	C	MI.8233	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	743	248	V	A	gTt/gCt	4.29	1	0	possibly_damaging	0.54	neutral	0.22	neutral	1.66	deleterious	-5.34	deleterious	-3.4	high_impact	4.01	0.63	neutral	0.7	neutral	3.60	23.20	deleterious	0.05	0.35	0.43	neutral	0.78	disease	0.67	disease	0.71	disease	4	0.77	neutral	0.34	neutral	1	deleterious	0.49	deleterious	-0.94	medium_impact	-0.12	medium_impact	2.41	high_impact	0.11	0.8	75.1	10.79	0.52	P	0.82	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9949	9949	T	A	MI.8234	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	743	248	V	D	gTt/gAt	4.29	1	0	possibly_damaging	0.9	neutral	0.18	neutral	1.57	deleterious	-8.62	deleterious	-5.95	high_impact	4.56	0.61	neutral	0.5	neutral	4.57	24.40	deleterious	0.02	0.35	0.8	disease	0.91	disease	0.76	disease	0.84	disease	7	0.94	neutral	0.14	neutral	1	deleterious	0.81	deleterious	-1.8	low_impact	-0.18	medium_impact	2.9	high_impact	0.09	0.8	75.1	10.79	0.53	P	0.97	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9949	9949	T	G	MI.8235	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	743	248	V	G	gTt/gGt	4.29	1	0	possibly_damaging	0.9	neutral	0.21	neutral	1.58	deleterious	-7.84	deleterious	-5.96	high_impact	4.56	0.61	neutral	0.66	neutral	3.96	23.60	deleterious	0.03	0.35	0.7	disease	0.85	disease	0.69	disease	0.75	disease	5	0.93	neutral	0.16	neutral	1	deleterious	0.79	deleterious	-1.8	low_impact	-0.14	medium_impact	2.9	high_impact	0.13	0.8	75.1	10.79	0.5	N	0.96	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9951	9951	T	C	MI.8236	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	745	249	W	R	Tga/Cga	-13.29	0	0	probably_damaging	1	neutral	0.05	neutral	-1.2	deleterious	-11.85	deleterious	-12.02	high_impact	3.98	0.48	damaging	0.16	damaging	3.69	23.30	deleterious	0.04	0.35	0.38	neutral	0.89	disease	0.76	disease	0.78	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.54	medium_impact	2.38	high_impact	0.09	0.8	74.33	11.7	0.41	N	0.99	polymorphism	1	0.46	rs879091798	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	9951	9951	T	G	MI.8237	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	745	249	W	G	Tga/Gga	-13.29	0	0	probably_damaging	1	neutral	0.05	neutral	-1.21	deleterious	-12.4	deleterious	-11.16	high_impact	3.98	0.6	damaging	0.37	neutral	4.01	23.60	deleterious	0.04	0.35	0.71	disease	0.83	disease	0.73	disease	0.77	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.54	medium_impact	2.38	high_impact	0.05	0.8	74.33	11.7	0.36	N	0.98	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9952	9952	G	T	MI.8238	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	746	249	W	L	tGa/tTa	7.3	1	0	probably_damaging	1	neutral	1	neutral	-1.2	deleterious	-10.54	deleterious	-11.15	high_impact	4.33	0.57	damaging	0.37	neutral	4.36	24.10	deleterious	0.04	0.35	0.31	neutral	0.88	disease	0.72	disease	0.78	disease	6	0.99	deleterious	0.5	deleterious	2	deleterious	0.78	deleterious	-3.78	low_impact	1.9	high_impact	2.7	high_impact	0.05	0.8	74.33	11.7	0.42	N	1.00	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9952	9952	G	C	MI.8239	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	746	249	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.06	neutral	-1.21	deleterious	-12.47	deleterious	-12.01	high_impact	4.67	0.63	neutral	0.36	neutral	4.09	23.70	deleterious	0.04	0.35	0.59	disease	0.88	disease	0.72	disease	0.78	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.83	deleterious	-3.78	low_impact	-0.49	medium_impact	3	high_impact	0.05	0.8	74.33	11.7	0.42	N	0.97	disease_causing	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8913	8913	A	T	MI.824	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	387	129	L	F	ttA/ttT	7.53	0.96	0	probably_damaging	1	deleterious	0	neutral	4.13	neutral	-1.33	deleterious	-3.67	high_impact	3.6	0.88	neutral	0.15	damaging	3.61	23.20	deleterious	0.41	0.65	0.75	disease	0.67	disease	0.69	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	1.99	medium_impact	0.58	0.9	49.12	8.65	0.54	P	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9953	9953	A	C	MI.8240	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	747	249	W	C	tgA/tgC	7.3	1	0	probably_damaging	1	deleterious	0.03	neutral	-1.21	deleterious	-14.66	deleterious	-11.15	high_impact	4.67	0.58	damaging	0.17	damaging	4.12	23.80	deleterious	0.04	0.35	0.82	disease	0.9	disease	0.74	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-3.78	low_impact	-0.67	medium_impact	3	high_impact	0.06	0.8	74.33	11.7	0.43	N	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9953	9953	A	T	MI.8241	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	747	249	W	C	tgA/tgT	7.3	1	0	probably_damaging	1	deleterious	0.03	neutral	-1.21	deleterious	-14.66	deleterious	-11.15	high_impact	4.67	0.58	damaging	0.17	damaging	4.23	23.90	deleterious	0.04	0.35	0.82	disease	0.9	disease	0.74	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-3.78	low_impact	-0.67	medium_impact	3	high_impact	0.06	0.8	74.33	11.7	0.43	N	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9954	9954	C	G	MI.8242	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	748	250	L	V	Cta/Gta	3.14	0.99	0	probably_damaging	0.91	neutral	0.43	neutral	2.19	neutral	-0.52	neutral	-2.14	low_impact	1.73	0.54	damaging	0.04	damaging	3.55	23.10	deleterious	0.15	0.4	0.21	neutral	0.68	disease	0.45	neutral	0.49	neutral	0	0.91	neutral	0.26	neutral	-2	neutral	0.64	deleterious	-1.85	low_impact	0.12	medium_impact	0.37	medium_impact	0.53	0.8	73.95	11.7	0.34	N	0.81	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9954	9954	C	A	MI.8243	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	748	250	L	M	Cta/Ata	3.14	0.99	0	probably_damaging	0.99	neutral	0.09	neutral	1.97	deleterious	-3.96	neutral	-1.56	high_impact	3.54	0.61	neutral	0.04	damaging	3.83	23.40	deleterious	0.12	0.4	0.46	neutral	0.54	disease	0.54	disease	0.62	disease	2	1	deleterious	0.05	neutral	2	deleterious	0.71	deleterious	-2.81	low_impact	-0.38	medium_impact	1.99	medium_impact	0.50	0.8	73.95	11.7	0.42	N	0.85	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9955	9955	T	A	MI.8244	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	749	250	L	Q	cTa/cAa	-0.57	0.13	0	probably_damaging	0.99	neutral	0.09	neutral	1.94	deleterious	-5.7	deleterious	-4.99	high_impact	4.23	0.62	neutral	0.02	damaging	4.38	24.10	deleterious	0.03	0.35	0.58	disease	0.75	disease	0.57	disease	0.67	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	-0.38	medium_impact	2.61	high_impact	0.30	0.8	73.95	11.7	0.35	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9955	9955	T	G	MI.8245	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	749	250	L	R	cTa/cGa	-0.57	0.13	0	probably_damaging	0.99	deleterious	0.03	neutral	1.94	deleterious	-6.08	deleterious	-5	high_impact	4.23	0.68	neutral	0.02	damaging	4.29	24.00	deleterious	0.02	0.35	0.73	disease	0.89	disease	0.68	disease	0.75	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-2.81	low_impact	-0.67	medium_impact	2.61	high_impact	0.12	0.8	73.95	11.7	0.33	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9955	9955	T	C	MI.8246	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	749	250	L	P	cTa/cCa	-0.57	0.13	0	probably_damaging	1	deleterious	0.02	neutral	1.95	deleterious	-6.45	deleterious	-5.75	high_impact	3.88	0.57	damaging	0.03	damaging	4.10	23.70	deleterious	0.02	0.35	0.79	disease	0.8	disease	0.68	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.78	low_impact	-0.77	medium_impact	2.3	high_impact	0.35	0.8	73.95	11.7	0.33	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9957	9957	T	C	MI.8247	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	751	251	F	L	Ttt/Ctt	-4.5	0	0	benign	0	neutral	0.9	neutral	1.92	neutral	-2.01	deleterious	-4.7	medium_impact	2.51	0.51	damaging	0.7	neutral	2.06	16.61	deleterious	0.13	0.4	0.21	neutral	0.78	disease	0.58	disease	0.52	disease	0	0.09	neutral	0.95	deleterious	-3	neutral	0.17	neutral	2.05	high_impact	0.74	medium_impact	1.07	medium_impact	0.34	0.8	62.07	11.69	0.46	N	0.41	polymorphism	1	0.11	.	.	.	.	.	.	.	CPD	3.56	T9957C	PEM / MELAS / NAION / HCM	-	+	Reported	7	.	P	P	damaging
chrM	9957	9957	T	A	MI.8248	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	751	251	F	I	Ttt/Att	-4.5	0	0	benign	0.01	neutral	0.08	neutral	1.86	neutral	-2.74	deleterious	-4.76	medium_impact	2.54	0.63	neutral	0.62	neutral	2.56	19.87	deleterious	0.15	0.4	0.28	neutral	0.85	disease	0.59	disease	0.69	disease	4	0.92	neutral	0.54	deleterious	-3	neutral	0.23	neutral	1.07	medium_impact	-0.41	medium_impact	1.09	medium_impact	0.30	0.8	62.07	11.69	0.42	N	0.78	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9957	9957	T	G	MI.8249	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	751	251	F	V	Ttt/Gtt	-4.5	0	0	benign	0.04	neutral	0.21	neutral	1.87	neutral	-2.6	deleterious	-5.61	medium_impact	2.64	0.67	neutral	0.56	neutral	2.23	17.69	deleterious	0.11	0.4	0.21	neutral	0.87	disease	0.63	disease	0.73	disease	5	0.78	neutral	0.59	deleterious	-3	neutral	0.19	neutral	0.47	medium_impact	-0.14	medium_impact	1.18	medium_impact	0.27	0.8	62.07	11.69	0.37	N	0.90	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8913	8913	A	C	MI.825	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	387	129	L	F	ttA/ttC	7.53	0.96	0	probably_damaging	1	deleterious	0	neutral	4.13	neutral	-1.33	deleterious	-3.67	high_impact	3.6	0.88	neutral	0.15	damaging	3.48	23.10	deleterious	0.41	0.65	0.75	disease	0.67	disease	0.69	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	1.99	medium_impact	0.58	0.9	49.12	8.65	0.54	P	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9958	9958	T	A	MI.8250	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	752	251	F	Y	tTt/tAt	4.52	1	0	benign	0.08	neutral	0.54	neutral	1.84	deleterious	-3.03	neutral	-2.47	high_impact	3.73	0.74	neutral	0.41	neutral	2.68	20.70	deleterious	0.2	0.45	0.3	neutral	0.83	disease	0.65	disease	0.72	disease	4	0.39	neutral	0.73	deleterious	-2	neutral	0.26	neutral	0.16	medium_impact	0.23	medium_impact	2.16	high_impact	0.39	0.8	62.07	11.69	0.52	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9958	9958	T	C	MI.8251	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	752	251	F	S	tTt/tCt	4.52	1	0	benign	0.17	neutral	0.21	neutral	1.82	deleterious	-3.57	deleterious	-6.54	high_impact	4.08	0.83	neutral	0.59	neutral	2.81	21.40	deleterious	0.07	0.35	0.4	neutral	0.82	disease	0.63	disease	0.71	disease	4	0.75	neutral	0.52	deleterious	-2	neutral	0.41	neutral	-0.2	medium_impact	-0.14	medium_impact	2.47	high_impact	0.20	0.8	62.07	11.69	0.55	P	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9958	9958	T	G	MI.8252	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	752	251	F	C	tTt/tGt	4.52	1	0	possibly_damaging	0.62	deleterious	0.01	neutral	1.78	deleterious	-5.42	deleterious	-6.43	medium_impact	2.98	0.74	neutral	0.45	neutral	4.17	23.80	deleterious	0.08	0.35	0.62	disease	0.86	disease	0.61	disease	0.68	disease	4	0.99	deleterious	0.2	neutral	4	deleterious	0.65	deleterious	-1.08	low_impact	-0.95	medium_impact	1.49	medium_impact	0.12	0.8	62.07	11.69	0.39	N	0.95	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9959	9959	T	A	MI.8253	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	753	251	F	L	ttT/ttA	5.68	1	0	benign	0	neutral	0.9	neutral	1.92	neutral	-2.01	deleterious	-4.7	medium_impact	2.51	0.51	damaging	0.7	neutral	2.63	20.40	deleterious	0.13	0.4	0.21	neutral	0.78	disease	0.58	disease	0.52	disease	0	0.09	neutral	0.95	deleterious	-3	neutral	0.17	neutral	2.05	high_impact	0.74	medium_impact	1.07	medium_impact	0.34	0.8	62.07	11.69	0.57	P	0.41	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9959	9959	T	G	MI.8254	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	753	251	F	L	ttT/ttG	5.68	1	0	benign	0	neutral	0.9	neutral	1.92	neutral	-2.01	deleterious	-4.7	medium_impact	2.51	0.51	damaging	0.7	neutral	2.50	19.46	deleterious	0.13	0.4	0.21	neutral	0.78	disease	0.58	disease	0.52	disease	0	0.09	neutral	0.95	deleterious	-3	neutral	0.17	neutral	2.05	high_impact	0.74	medium_impact	1.07	medium_impact	0.34	0.8	62.07	11.69	0.56	P	0.41	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9960	9960	C	A	MI.8255	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	754	252	L	M	Ctg/Atg	2.9	1	0	probably_damaging	1	deleterious	0.03	neutral	1.7	deleterious	-4.07	neutral	-1.72	high_impact	4.04	0.58	damaging	0.04	damaging	3.90	23.50	deleterious	0.12	0.4	0.46	neutral	0.61	disease	0.54	disease	0.63	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.72	deleterious	-3.78	low_impact	-0.67	medium_impact	2.44	high_impact	0.45	0.8	74.71	11.64	0.38	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9960	9960	C	G	MI.8256	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	754	252	L	V	Ctg/Gtg	2.9	1	0	probably_damaging	0.95	neutral	0.22	neutral	1.92	neutral	-2.04	deleterious	-2.58	medium_impact	2.41	0.48	damaging	0.05	damaging	3.58	23.20	deleterious	0.15	0.45	0.19	neutral	0.72	disease	0.54	disease	0.51	disease	0	0.97	neutral	0.14	neutral	1	deleterious	0.67	deleterious	-2.11	low_impact	-0.12	medium_impact	0.98	medium_impact	0.42	0.8	74.71	11.64	0.38	N	0.81	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9961	9961	T	G	MI.8257	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	755	252	L	R	cTg/cGg	0.13	0.98	0	probably_damaging	1	deleterious	0.04	neutral	1.62	deleterious	-8.17	deleterious	-5.15	high_impact	4.59	0.68	neutral	0.02	damaging	4.27	23.90	deleterious	0.03	0.35	0.65	disease	0.91	disease	0.74	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-3.78	low_impact	-0.6	medium_impact	2.93	high_impact	0.17	0.8	74.71	11.64	0.49	N	0.99	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9961	9961	T	A	MI.8258	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	755	252	L	Q	cTg/cAg	0.13	0.98	0	probably_damaging	1	deleterious	0.03	neutral	1.62	deleterious	-8.29	deleterious	-5.14	high_impact	4.59	0.6	damaging	0.03	damaging	4.15	23.80	deleterious	0.03	0.35	0.66	disease	0.81	disease	0.63	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.80	deleterious	-3.78	low_impact	-0.67	medium_impact	2.93	high_impact	0.23	0.8	74.71	11.64	0.44	N	0.97	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9961	9961	T	C	MI.8259	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	755	252	L	P	cTg/cCg	0.13	0.98	0	probably_damaging	1	deleterious	0.02	neutral	1.62	deleterious	-7.76	deleterious	-6	high_impact	4.04	0.48	damaging	0.03	damaging	3.95	23.60	deleterious	0.02	0.35	0.59	disease	0.83	disease	0.71	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.84	deleterious	-3.78	low_impact	-0.77	medium_impact	2.44	high_impact	0.22	0.8	74.71	11.64	0.38	N	0.99	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8914	8914	C	A	MI.826	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	388	130	P	T	Cca/Aca	-6.81	0	0	probably_damaging	1	deleterious	0.04	neutral	3.42	deleterious	-3.05	deleterious	-7.29	high_impact	3.53	0.59	damaging	0.07	damaging	3.71	23.30	deleterious	0.44	0.65	0.71	disease	0.8	disease	0.71	disease	0.7	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-0.49	medium_impact	1.93	medium_impact	0.68	0.9	49.12	8.75	0.26	N	0.93	disease_causing	0.74	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9963	9963	T	A	MI.8260	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	757	253	Y	N	Tat/Aat	-14.91	0	0	probably_damaging	1	neutral	0.07	neutral	1.71	deleterious	-5.14	deleterious	-6.86	high_impact	3.93	0.62	neutral	0.37	neutral	4.13	23.80	deleterious	0.06	0.35	0.39	neutral	0.87	disease	0.65	disease	0.75	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	-0.45	medium_impact	2.34	high_impact	0.11	0.8	74.71	12.44	0.34	N	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9963	9963	T	C	MI.8261	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	757	253	Y	H	Tat/Cat	-14.91	0	0	probably_damaging	1	neutral	0.22	neutral	1.74	deleterious	-4.08	deleterious	-4	high_impact	3.93	0.67	neutral	0.39	neutral	3.64	23.20	deleterious	0.08	0.35	0.48	neutral	0.81	disease	0.72	disease	0.73	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.76	deleterious	-3.78	low_impact	-0.12	medium_impact	2.34	high_impact	0.17	0.8	74.71	12.44	0.39	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9963	9963	T	G	MI.8262	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	757	253	Y	D	Tat/Gat	-14.91	0	0	probably_damaging	1	neutral	0.14	neutral	1.7	deleterious	-6.15	deleterious	-7.42	high_impact	3.93	0.66	neutral	0.4	neutral	4.06	23.70	deleterious	0.03	0.35	0.43	neutral	0.88	disease	0.74	disease	0.8	disease	6	1	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-3.78	low_impact	-0.26	medium_impact	2.34	high_impact	0.15	0.8	74.71	12.44	0.4	N	0.99	disease_causing	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9964	9964	A	C	MI.8263	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	758	253	Y	S	tAt/tCt	5.68	1	0	probably_damaging	1	neutral	0.28	neutral	1.72	deleterious	-4.75	deleterious	-6.56	medium_impact	3.24	0.71	neutral	0.5	neutral	3.99	23.60	deleterious	0.06	0.35	0.29	neutral	0.84	disease	0.63	disease	0.73	disease	5	1	deleterious	0.14	neutral	1	deleterious	0.74	deleterious	-3.78	low_impact	-0.04	medium_impact	1.72	medium_impact	0.13	0.8	74.71	12.44	0.46	N	0.96	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9964	9964	A	T	MI.8264	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	758	253	Y	F	tAt/tTt	5.68	1	0	probably_damaging	0.99	neutral	0.62	neutral	2.13	neutral	-0.61	neutral	-1.41	neutral_impact	0.09	0.57	damaging	0.75	neutral	2.42	18.94	deleterious	0.18	0.45	0.12	neutral	0.29	neutral	0.42	neutral	0.38	neutral	2	0.99	deleterious	0.32	neutral	-2	neutral	0.68	deleterious	-2.81	low_impact	0.31	medium_impact	-1.1	low_impact	0.34	0.8	74.71	12.44	0.51	P	0.72	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9964	9964	A	G	MI.8265	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	758	253	Y	C	tAt/tGt	5.68	1	0	probably_damaging	1	neutral	0.13	neutral	1.7	deleterious	-6.31	deleterious	-6.56	high_impact	3.58	0.61	neutral	0.25	damaging	3.71	23.30	deleterious	0.06	0.35	0.58	disease	0.9	disease	0.69	disease	0.77	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.78	deleterious	-3.78	low_impact	-0.28	medium_impact	2.03	high_impact	0.12	0.8	74.71	12.44	0.43	N	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9966	9966	G	A	MI.8266	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	760	254	V	I	Gtc/Atc	-4.73	0	0.03	benign	0	neutral	0.59	neutral	2.22	neutral	-0.48	neutral	0.19	neutral_impact	-0.12	0.92	neutral	0.96	neutral	-0.85	0.03	neutral	0.34	0.5	0.18	neutral	0.09	neutral	0.19	neutral	0.26	neutral	5	0.41	neutral	0.8	deleterious	-6	neutral	0.07	neutral	2.05	high_impact	0.28	medium_impact	-1.29	low_impact	0.73	0.85	NA	NA	0.4	N	0.06	polymorphism	1	0.01	rs200809063	Likely_benign	not_provided	363898	MedGen:CN517202	.	.	.	.	G9966A	LHON possible helper variant	.	.	Reported	1	N	.	N	neutral
chrM	9966	9966	G	T	MI.8267	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	760	254	V	F	Gtc/Ttc	-4.73	0	0.03	benign	0.13	neutral	0.48	neutral	1.97	deleterious	-3.18	deleterious	-2.83	low_impact	1.63	0.63	neutral	0.45	neutral	1.99	16.16	deleterious	0.05	0.35	0.29	neutral	0.79	disease	0.44	neutral	0.55	disease	1	0.43	neutral	0.68	deleterious	-6	neutral	0.27	neutral	-0.07	medium_impact	0.17	medium_impact	0.28	medium_impact	0.33	0.8	NA	NA	0.34	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9966	9966	G	C	MI.8268	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	760	254	V	L	Gtc/Ctc	-4.73	0	0.03	benign	0	neutral	0.54	neutral	2.14	neutral	-0.93	neutral	-1.12	neutral_impact	0.07	0.75	neutral	0.79	neutral	0.55	7.80	deleterious	0.19	0.45	0.18	neutral	0.47	neutral	0.26	neutral	0.46	neutral	1	0.46	neutral	0.77	deleterious	-6	neutral	0.12	neutral	2.05	high_impact	0.23	medium_impact	-1.12	low_impact	0.54	0.8	NA	NA	0.37	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9967	9967	T	C	MI.8269	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	761	254	V	A	gTc/gCc	0.36	0.13	0	benign	0.07	neutral	0.21	neutral	2.01	neutral	-2.38	deleterious	-2.9	low_impact	0.86	0.7	neutral	0.7	neutral	1.72	14.52	neutral	0.13	0.4	0.2	neutral	0.53	disease	0.45	neutral	0.46	neutral	1	0.77	neutral	0.57	deleterious	-6	neutral	0.16	neutral	0.22	medium_impact	-0.14	medium_impact	-0.41	medium_impact	0.28	0.8	NA	NA	0.46	N	0.82	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8914	8914	C	T	MI.827	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	388	130	P	S	Cca/Tca	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	3.42	neutral	-2.76	deleterious	-7.29	high_impact	4.63	0.59	damaging	0.08	damaging	3.93	23.50	deleterious	0.48	0.65	0.85	disease	0.78	disease	0.71	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.28	0.9	49.12	8.75	0.38	N	0.82	disease_causing	0.75	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9967	9967	T	A	MI.8270	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	761	254	V	D	gTc/gAc	0.36	0.13	0	benign	0.31	neutral	0.15	neutral	1.94	deleterious	-4.88	deleterious	-4.89	medium_impact	3.28	0.62	neutral	0.34	neutral	2.92	22.00	deleterious	0.02	0.35	0.57	disease	0.82	disease	0.64	disease	0.77	disease	5	0.82	neutral	0.42	neutral	-3	neutral	0.54	deleterious	-0.53	medium_impact	-0.24	medium_impact	1.76	medium_impact	0.08	0.8	NA	NA	0.37	N	0.97	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9967	9967	T	G	MI.8271	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	761	254	V	G	gTc/gGc	0.36	0.13	0	benign	0.37	neutral	0.13	neutral	1.95	deleterious	-4.24	deleterious	-5.39	low_impact	1.49	0.63	neutral	0.53	neutral	2.30	18.17	deleterious	0.04	0.35	0.29	neutral	0.67	disease	0.55	disease	0.7	disease	4	0.85	neutral	0.38	neutral	-6	neutral	0.39	neutral	-0.64	medium_impact	-0.28	medium_impact	0.15	medium_impact	0.16	0.8	NA	NA	0.41	N	0.96	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9969	9969	T	A	MI.8272	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	763	255	S	T	Tcc/Acc	-12.37	0	0	probably_damaging	0.96	neutral	0.16	neutral	2.58	neutral	0.38	neutral	-2	low_impact	1.32	0.67	neutral	0.77	neutral	3.83	23.40	deleterious	0.4	0.5	0.19	neutral	0.41	neutral	0.42	neutral	0.44	neutral	1	0.98	neutral	0.1	neutral	-2	neutral	0.60	deleterious	-2.21	low_impact	-0.22	medium_impact	0	medium_impact	0.68	0.85	73.56	12.63	0.48	N	0.63	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9969	9969	T	C	MI.8273	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	763	255	S	P	Tcc/Ccc	-12.37	0	0	probably_damaging	1	neutral	0.05	neutral	2.51	neutral	-2.23	deleterious	-3.81	medium_impact	3.28	0.58	damaging	0.46	neutral	4.07	23.70	deleterious	0.05	0.35	0.51	disease	0.81	disease	0.67	disease	0.72	disease	4	1	deleterious	0.03	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	-0.54	medium_impact	1.76	medium_impact	0.36	0.8	73.56	12.63	0.35	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9969	9969	T	G	MI.8274	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	763	255	S	A	Tcc/Gcc	-12.37	0	0	probably_damaging	0.98	neutral	0.12	neutral	2.58	neutral	0.66	neutral	-2	low_impact	1.92	0.64	neutral	0.65	neutral	3.75	23.30	deleterious	0.38	0.5	0.22	neutral	0.46	neutral	0.44	neutral	0.45	neutral	1	0.99	deleterious	0.07	neutral	-2	neutral	0.66	deleterious	-2.51	low_impact	-0.3	medium_impact	0.54	medium_impact	0.54	0.8	73.56	12.63	0.46	N	0.40	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9970	9970	C	T	MI.8275	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	764	255	S	F	tCc/tTc	3.6	1	0	probably_damaging	1	neutral	0.2	neutral	2.67	neutral	1.53	deleterious	-4.26	low_impact	0.84	0.63	neutral	0.77	neutral	4.39	24.10	deleterious	0.08	0.35	0.23	neutral	0.61	disease	0.5	neutral	0.45	neutral	1	1	deleterious	0.1	neutral	-2	neutral	0.70	deleterious	-3.78	low_impact	-0.15	medium_impact	-0.43	medium_impact	0.20	0.8	73.56	12.63	0.42	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9970	9970	C	A	MI.8276	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	764	255	S	Y	tCc/tAc	3.6	1	0	probably_damaging	1	neutral	1	neutral	2.53	neutral	-1.18	deleterious	-4.3	high_impact	3.62	0.63	neutral	0.39	neutral	4.21	23.90	deleterious	0.06	0.35	0.33	neutral	0.8	disease	0.57	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.73	deleterious	-3.78	low_impact	1.9	high_impact	2.06	high_impact	0.30	0.8	73.56	12.63	0.36	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9970	9970	C	G	MI.8277	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	764	255	S	C	tCc/tGc	3.6	1	0	probably_damaging	1	neutral	0.06	neutral	2.51	neutral	-1.3	neutral	-2.34	low_impact	1.11	0.61	neutral	0.75	neutral	2.59	20.10	deleterious	0.1	0.4	0.51	disease	0.58	disease	0.44	neutral	0.49	neutral	0	1	deleterious	0.03	neutral	-2	neutral	0.72	deleterious	-3.78	low_impact	-0.49	medium_impact	-0.19	medium_impact	0.41	0.8	73.56	12.63	0.45	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	9972	9972	A	T	MI.8278	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	766	256	I	F	Atc/Ttc	-12.37	0	0	possibly_damaging	0.64	neutral	0.63	neutral	1.97	neutral	-0.37	deleterious	-3.42	medium_impact	2.46	0.65	neutral	0.37	neutral	4.06	23.70	deleterious	0.13	0.4	0.28	neutral	0.63	disease	0.54	disease	0.48	neutral	0	0.57	neutral	0.5	deleterious	0	NA	0.59	deleterious	-1.11	low_impact	0.32	medium_impact	1.02	medium_impact	0.54	0.8	75.1	12.41	0.29	N	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9972	9972	A	G	MI.8279	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	766	256	I	V	Atc/Gtc	-12.37	0	0	benign	0	neutral	0.46	neutral	2.33	neutral	0.34	neutral	-0.71	neutral_impact	0.76	0.66	neutral	0.78	neutral	0.41	6.72	deleterious	0.55	0.6	0.12	neutral	0.1	neutral	0.35	neutral	0.29	neutral	4	0.54	neutral	0.73	deleterious	-6	neutral	0.08	neutral	2.05	high_impact	0.15	medium_impact	-0.5	medium_impact	0.51	0.8	75.1	12.41	0.4	N	0.18	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8914	8914	C	G	MI.828	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	388	130	P	A	Cca/Gca	-6.81	0	0	probably_damaging	1	deleterious	0	neutral	3.42	deleterious	-3	deleterious	-7.29	high_impact	4.63	0.57	damaging	0.1	damaging	3.09	22.50	deleterious	0.34	0.65	0.83	disease	0.58	disease	0.72	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.77	0.9	49.12	8.75	0.42	N	0.79	disease_causing	0.64	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9972	9972	A	C	MI.8280	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	766	256	I	L	Atc/Ctc	-12.37	0	0	benign	0.08	neutral	0.5	neutral	2.14	neutral	-0.26	neutral	-1.7	medium_impact	2.07	0.71	neutral	0.48	neutral	2.28	18.01	deleterious	0.24	0.45	0.16	neutral	0.47	neutral	0.47	neutral	0.43	neutral	1	0.44	neutral	0.71	deleterious	-3	neutral	0.14	neutral	0.16	medium_impact	0.19	medium_impact	0.67	medium_impact	0.53	0.8	75.1	12.41	0.36	N	0.58	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	A9972C	EXIT & APS2 - possible link	-	+	Reported	1	.	P	P	damaging
chrM	9973	9973	T	G	MI.8281	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	767	256	I	S	aTc/aGc	6.84	1	0	probably_damaging	0.97	neutral	0.6	neutral	1.94	deleterious	-3.32	deleterious	-5.06	high_impact	4.18	0.76	neutral	0.47	neutral	4.62	24.50	deleterious	0.02	0.35	0.46	neutral	0.69	disease	0.6	disease	0.66	disease	3	0.97	neutral	0.32	neutral	2	deleterious	0.70	deleterious	-2.34	low_impact	0.29	medium_impact	2.56	high_impact	0.17	0.8	75.1	12.41	0.49	N	0.96	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9973	9973	T	C	MI.8282	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	767	256	I	T	aTc/aCc	6.84	1	0	probably_damaging	0.9	neutral	0.3	neutral	1.96	neutral	-2.86	deleterious	-4.14	high_impact	3.84	0.71	neutral	0.48	neutral	3.70	23.30	deleterious	0.05	0.35	0.39	neutral	0.53	disease	0.59	disease	0.65	disease	3	0.92	neutral	0.2	neutral	2	deleterious	0.59	deleterious	-1.8	low_impact	-0.02	medium_impact	2.26	high_impact	0.23	0.8	75.1	12.41	0.56	P	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9973	9973	T	A	MI.8283	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	767	256	I	N	aTc/aAc	6.84	1	0	probably_damaging	0.99	neutral	0.24	neutral	1.92	deleterious	-4.55	deleterious	-5.92	high_impact	3.84	0.66	neutral	0.34	neutral	4.73	24.60	deleterious	0.07	0.35	0.64	disease	0.74	disease	0.63	disease	0.68	disease	4	0.99	deleterious	0.13	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	-0.09	medium_impact	2.26	high_impact	0.28	0.8	75.1	12.41	0.52	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9974	9974	C	A	MI.8284	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	768	256	I	M	atC/atA	5.68	1	0	possibly_damaging	0.8	neutral	0.24	neutral	1.99	neutral	-2.69	neutral	-2.49	medium_impact	2.73	0.64	neutral	0.77	neutral	2.38	18.66	deleterious	0.17	0.45	0.37	neutral	0.27	neutral	0.53	disease	0.45	neutral	1	0.86	neutral	0.22	neutral	0	NA	0.40	neutral	-1.45	low_impact	-0.09	medium_impact	1.26	medium_impact	0.52	0.8	75.1	12.41	0.59	P	0.82	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9974	9974	C	G	MI.8285	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	768	256	I	M	atC/atG	5.68	1	0	possibly_damaging	0.8	neutral	0.24	neutral	1.99	neutral	-2.69	neutral	-2.49	medium_impact	2.73	0.64	neutral	0.77	neutral	1.94	15.81	deleterious	0.17	0.45	0.37	neutral	0.27	neutral	0.53	disease	0.45	neutral	1	0.86	neutral	0.22	neutral	0	NA	0.40	neutral	-1.45	low_impact	-0.09	medium_impact	1.26	medium_impact	0.52	0.8	75.1	12.41	0.59	P	0.82	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9975	9975	T	A	MI.8286	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	769	257	Y	N	Tat/Aat	-3.57	0	0	probably_damaging	1	neutral	0.09	neutral	0.63	deleterious	-8.63	deleterious	-7.68	high_impact	4.7	0.6	damaging	0.02	damaging	4.32	24.00	deleterious	0.04	0.35	0.77	disease	0.67	disease	0.76	disease	0.77	disease	5	1	deleterious	0.05	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.38	medium_impact	3.03	high_impact	0.09	0.8	72.8	13.53	0.44	N	1.00	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9975	9975	T	G	MI.8287	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	769	257	Y	D	Tat/Gat	-3.57	0	0	probably_damaging	1	neutral	0.06	neutral	0.62	deleterious	-9.55	deleterious	-8.54	high_impact	4.7	0.64	neutral	0.02	damaging	4.26	23.90	deleterious	0.02	0.35	0.79	disease	0.66	disease	0.82	disease	0.76	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	-0.49	medium_impact	3.03	high_impact	0.13	0.8	72.8	13.53	0.44	N	0.99	disease_causing	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9975	9975	T	C	MI.8288	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	769	257	Y	H	Tat/Cat	-3.57	0	0	probably_damaging	1	neutral	0.24	neutral	0.65	deleterious	-6.99	deleterious	-4.27	high_impact	4.35	0.57	damaging	0.02	damaging	3.86	23.50	deleterious	0.06	0.35	0.73	disease	0.56	disease	0.81	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.79	deleterious	-3.78	low_impact	-0.09	medium_impact	2.72	high_impact	0.14	0.8	72.8	13.53	0.42	N	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9976	9976	A	C	MI.8289	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	770	257	Y	S	tAt/tCt	5.68	1	0	probably_damaging	1	neutral	0.32	neutral	0.63	deleterious	-8.58	deleterious	-7.68	high_impact	4.7	0.63	neutral	0.04	damaging	4.05	23.70	deleterious	0.03	0.35	0.69	disease	0.61	disease	0.75	disease	0.75	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.80	deleterious	-3.78	low_impact	0.01	medium_impact	3.03	high_impact	0.11	0.8	72.8	13.53	0.58	P	0.96	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8915	8915	C	A	MI.829	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	389	130	P	Q	cCa/cAa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	3.4	deleterious	-3.21	deleterious	-7.31	high_impact	4.63	0.55	damaging	0.06	damaging	4.13	23.80	deleterious	0.29	0.65	0.95	disease	0.86	disease	0.74	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.56	0.9	49.12	8.75	0.54	P	0.82	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9976	9976	A	G	MI.8290	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	770	257	Y	C	tAt/tGt	5.68	1	0	probably_damaging	1	neutral	0.05	neutral	0.62	deleterious	-9.08	deleterious	-7.57	high_impact	4.7	0.66	neutral	0.02	damaging	3.87	23.50	deleterious	0.03	0.35	0.88	disease	0.68	disease	0.78	disease	0.79	disease	6	1	deleterious	0.03	neutral	2	deleterious	0.82	deleterious	-3.78	low_impact	-0.54	medium_impact	3.03	high_impact	0.18	0.8	72.8	13.53	0.55	P	1.00	polymorphism	1	0.45	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9976	9976	A	T	MI.8291	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	770	257	Y	F	tAt/tTt	5.68	1	0	probably_damaging	0.99	neutral	0.27	neutral	0.75	deleterious	-4.9	deleterious	-3.41	high_impact	4.14	0.6	damaging	0.03	damaging	3.96	23.60	deleterious	0.12	0.4	0.43	neutral	0.59	disease	0.73	disease	0.72	disease	4	0.99	deleterious	0.14	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	-0.06	medium_impact	2.53	high_impact	0.28	0.8	72.8	13.53	0.57	P	0.72	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9978	9978	T	G	MI.8292	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	772	258	W	G	Tga/Gga	-0.1	0.8	0	benign	0.1	neutral	0.44	neutral	2.43	neutral	-2.72	deleterious	-10.61	medium_impact	3.43	0.53	damaging	0.38	neutral	2.52	19.60	deleterious	0.04	0.35	0.4	neutral	0.54	disease	0.71	disease	0.7	disease	4	0.49	neutral	0.67	deleterious	-3	neutral	0.28	neutral	0.06	medium_impact	0.13	medium_impact	1.89	medium_impact	0.08	0.8	75.1	12.93	0.36	N	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9978	9978	T	C	MI.8293	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	772	258	W	R	Tga/Cga	-0.1	0.8	0	benign	0	neutral	0.07	neutral	2.44	neutral	-2.34	deleterious	-11.42	high_impact	4.12	0.6	neutral	0.17	damaging	1.93	15.78	deleterious	0.04	0.35	0.28	neutral	0.69	disease	0.74	disease	0.72	disease	4	0.93	neutral	0.54	deleterious	-2	neutral	0.22	neutral	2.05	high_impact	-0.45	medium_impact	2.51	high_impact	0.07	0.8	75.1	12.93	0.44	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9979	9979	G	C	MI.8294	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	773	258	W	S	tGa/tCa	4.52	1	0	benign	0.09	neutral	0.19	neutral	2.44	neutral	-2.23	deleterious	-11.35	high_impact	4.12	0.65	neutral	0.33	neutral	2.67	20.60	deleterious	0.06	0.35	0.26	neutral	0.66	disease	0.7	disease	0.69	disease	4	0.79	neutral	0.55	deleterious	-2	neutral	0.30	neutral	0.11	medium_impact	-0.17	medium_impact	2.51	high_impact	0.08	0.8	75.1	12.93	0.55	P	0.97	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9979	9979	G	T	MI.8295	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	773	258	W	L	tGa/tTa	4.52	1	0	benign	0.06	neutral	0.34	neutral	2.84	neutral	1.38	deleterious	-10.55	low_impact	1.82	0.61	neutral	0.36	neutral	2.75	21.10	deleterious	0.1	0.4	0.08	neutral	0.61	disease	0.66	disease	0.64	disease	3	0.63	neutral	0.64	deleterious	-6	neutral	0.24	neutral	0.29	medium_impact	0.03	medium_impact	0.45	medium_impact	0.06	0.8	75.1	12.93	0.48	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9980	9980	A	T	MI.8296	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	774	258	W	C	tgA/tgT	7.3	1	0	possibly_damaging	0.56	neutral	0.12	neutral	2.42	deleterious	-3.19	deleterious	-10.22	medium_impact	2.15	0.62	neutral	0.17	damaging	4.26	23.90	deleterious	0.05	0.35	0.47	neutral	0.68	disease	0.7	disease	0.66	disease	3	0.88	neutral	0.28	neutral	0	NA	0.62	deleterious	-0.97	medium_impact	-0.3	medium_impact	0.74	medium_impact	0.06	0.8	75.1	12.93	0.45	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9980	9980	A	C	MI.8297	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	774	258	W	C	tgA/tgC	7.3	1	0	possibly_damaging	0.56	neutral	0.12	neutral	2.42	deleterious	-3.19	deleterious	-10.22	medium_impact	2.15	0.62	neutral	0.17	damaging	4.28	24.00	deleterious	0.05	0.35	0.47	neutral	0.68	disease	0.7	disease	0.66	disease	3	0.88	neutral	0.28	neutral	0	NA	0.62	deleterious	-0.97	medium_impact	-0.3	medium_impact	0.74	medium_impact	0.06	0.8	75.1	12.93	0.45	N	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9981	9981	T	G	MI.8298	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	775	259	W	G	Tga/Gga	6.84	1	0	probably_damaging	0.96	neutral	0.22	neutral	1.75	deleterious	-4.9	deleterious	-10.19	high_impact	3.96	0.55	damaging	0.13	damaging	4.12	23.80	deleterious	0.1	0.4	0.38	neutral	0.55	disease	0.75	disease	0.74	disease	5	0.98	neutral	0.13	neutral	2	deleterious	0.72	deleterious	-2.21	low_impact	-0.12	medium_impact	2.37	high_impact	0.15	0.8	73.56	12.88	0.47	N	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9981	9981	T	C	MI.8299	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	775	259	W	R	Tga/Cga	6.84	1	0	probably_damaging	0.99	neutral	0.05	neutral	1.76	deleterious	-4.36	deleterious	-11.1	high_impact	4.3	0.64	neutral	0.05	damaging	3.81	23.40	deleterious	0.12	0.4	0.34	neutral	0.68	disease	0.74	disease	0.73	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.77	deleterious	-2.81	low_impact	-0.54	medium_impact	2.67	high_impact	0.06	0.8	73.56	12.88	0.45	N	0.99	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8563	8563	A	G	MI.83	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	37	13	T	A	Aca/Gca	-8.89	0	0.12	probably_damaging	0.99	neutral	0.1	neutral	4.58	neutral	-0.53	deleterious	-2.73	medium_impact	2.1	0.91	neutral	0.7	neutral	3.22	22.70	deleterious	0.65	0.7	0.45	neutral	0.55	disease	0.58	disease	0.64	disease	3	0.99	deleterious	0.06	neutral	1	deleterious	0.68	deleterious	-2.65	low_impact	-0.25	medium_impact	0.7	medium_impact	0.41	0.9	15.49	16.77	0.46	N	0.74	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8915	8915	C	G	MI.830	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	389	130	P	R	cCa/cGa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	3.4	deleterious	-3.33	deleterious	-8.23	high_impact	4.63	0.58	damaging	0.06	damaging	3.54	23.10	deleterious	0.35	0.65	0.95	disease	0.87	disease	0.78	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.57	0.9	49.12	8.75	0.59	P	0.65	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9982	9982	G	C	MI.8300	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	776	259	W	S	tGa/tCa	5.68	1	0	probably_damaging	0.99	neutral	0.34	neutral	1.77	deleterious	-4.14	deleterious	-10.9	high_impact	3.75	0.69	neutral	0.05	damaging	4.26	23.90	deleterious	0.12	0.4	0.24	neutral	0.67	disease	0.74	disease	0.73	disease	5	0.99	deleterious	0.18	neutral	2	deleterious	0.76	deleterious	-2.81	low_impact	0.03	medium_impact	2.18	high_impact	0.13	0.8	73.56	12.88	0.43	N	0.97	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9982	9982	G	T	MI.8301	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	776	259	W	L	tGa/tTa	5.68	1	0	probably_damaging	0.96	neutral	0.15	neutral	1.89	neutral	-2.09	deleterious	-10.35	medium_impact	2.31	0.62	neutral	0.07	damaging	4.48	24.20	deleterious	0.13	0.4	0.13	neutral	0.6	disease	0.72	disease	0.71	disease	4	0.98	deleterious	0.1	neutral	1	deleterious	0.71	deleterious	-2.21	low_impact	-0.24	medium_impact	0.89	medium_impact	0.10	0.8	73.56	12.88	0.41	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9983	9983	A	C	MI.8302	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	777	259	W	C	tgA/tgC	7.3	1	0	probably_damaging	0.99	neutral	0.06	neutral	1.74	deleterious	-5.92	deleterious	-10.25	high_impact	4.3	0.64	neutral	0.04	damaging	4.24	23.90	deleterious	0.09	0.35	0.45	neutral	0.67	disease	0.76	disease	0.74	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.77	deleterious	-2.81	low_impact	-0.49	medium_impact	2.67	high_impact	0.09	0.8	73.56	12.88	0.46	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9983	9983	A	T	MI.8303	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	777	259	W	C	tgA/tgT	7.3	1	0	probably_damaging	0.99	neutral	0.06	neutral	1.74	deleterious	-5.92	deleterious	-10.25	high_impact	4.3	0.64	neutral	0.04	damaging	4.32	24.00	deleterious	0.09	0.35	0.45	neutral	0.67	disease	0.76	disease	0.74	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.77	deleterious	-2.81	low_impact	-0.49	medium_impact	2.67	high_impact	0.09	0.8	73.56	12.88	0.47	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9984	9984	G	T	MI.8304	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	778	260	G	W	Ggg/Tgg	6.84	1	0	probably_damaging	1	neutral	0.54	neutral	2.03	deleterious	-6.5	deleterious	-6.54	high_impact	4.19	0.58	damaging	0.02	damaging	4.76	24.70	deleterious	0.08	0.35	0.93	disease	0.66	disease	0.71	disease	0.77	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.78	low_impact	0.23	medium_impact	2.57	high_impact	0.09	0.8	73.56	12.64	0.48	N	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9984	9984	G	C	MI.8305	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	778	260	G	R	Ggg/Cgg	6.84	1	0	probably_damaging	1	neutral	0.32	neutral	2.11	neutral	-2.81	deleterious	-6.54	medium_impact	2.84	0.62	neutral	0.03	damaging	4.23	23.90	deleterious	0.11	0.4	0.47	neutral	0.57	disease	0.67	disease	0.67	disease	3	1	deleterious	0.16	neutral	1	deleterious	0.80	deleterious	-3.78	low_impact	0.01	medium_impact	1.36	medium_impact	0.51	0.8	73.56	12.64	0.45	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9985	9985	G	C	MI.8306	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	779	260	G	A	gGg/gCg	9.15	1	0	probably_damaging	0.99	neutral	0.46	neutral	2.09	deleterious	-3.29	deleterious	-4.9	medium_impact	2.95	0.54	damaging	0.05	damaging	3.37	22.90	deleterious	0.16	0.45	0.46	neutral	0.34	neutral	0.55	disease	0.42	neutral	2	0.99	deleterious	0.24	neutral	1	deleterious	0.76	deleterious	-2.81	low_impact	0.15	medium_impact	1.46	medium_impact	0.32	0.8	73.56	12.64	0.5	N	0.31	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9985	9985	G	T	MI.8307	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	779	260	G	V	gGg/gTg	9.15	1	0	probably_damaging	1	neutral	0.5	neutral	2.04	deleterious	-5.02	deleterious	-7.36	medium_impact	3.29	0.51	damaging	0.01	damaging	4.01	23.60	deleterious	0.08	0.35	0.67	disease	0.58	disease	0.66	disease	0.67	disease	3	1	deleterious	0.25	neutral	1	deleterious	0.81	deleterious	-3.78	low_impact	0.19	medium_impact	1.77	medium_impact	0.10	0.8	73.56	12.64	0.44	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9985	9985	G	A	MI.8308	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	779	260	G	E	gGg/gAg	9.15	1	0	probably_damaging	1	neutral	0.25	neutral	2.11	neutral	-2.87	deleterious	-6.54	high_impact	3.64	0.52	damaging	0.02	damaging	4.19	23.80	deleterious	0.11	0.4	0.58	disease	0.56	disease	0.7	disease	0.69	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.81	deleterious	-3.78	low_impact	-0.08	medium_impact	2.08	high_impact	0.24	0.8	73.56	12.64	0.51	P	0.99	polymorphism	1	0.35	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9987	9987	T	G	MI.8309	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	781	261	S	A	Tct/Gct	-5.19	0	0	possibly_damaging	0.75	neutral	1	neutral	2.23	neutral	-0.49	neutral	-1.8	low_impact	1.82	0.6	neutral	0.68	neutral	1.96	15.93	deleterious	0.61	0.65	NA	NA	0.15	neutral	0.27	neutral	0.22	neutral	6	0.75	neutral	0.63	deleterious	-3	neutral	0.48	deleterious	-1.33	low_impact	1.9	high_impact	0.45	medium_impact	0.33	0.8	NA	NA	0.3	N	0.46	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8915	8915	C	T	MI.831	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	389	130	P	L	cCa/cTa	5.68	1	0	probably_damaging	1	deleterious	0	neutral	3.43	deleterious	-3.61	deleterious	-9.14	high_impact	4.63	0.54	damaging	0.05	damaging	4.34	24.00	deleterious	0.39	0.65	0.96	disease	0.82	disease	0.71	disease	0.71	disease	4	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.75	0.9	49.12	8.75	0.54	P	0.95	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9987	9987	T	A	MI.8310	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	781	261	S	T	Tct/Act	-5.19	0	0	possibly_damaging	0.62	neutral	0.52	neutral	2.19	neutral	-1.37	neutral	-1.93	medium_impact	2.57	0.62	neutral	0.49	neutral	2.12	16.99	deleterious	0.56	0.6	NA	NA	0.17	neutral	0.41	neutral	0.21	neutral	6	0.59	neutral	0.45	neutral	0	NA	0.60	deleterious	-1.08	low_impact	0.21	medium_impact	1.12	medium_impact	0.44	0.8	NA	NA	0.39	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9987	9987	T	C	MI.8311	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	781	261	S	P	Tct/Cct	-5.19	0	0	probably_damaging	0.93	neutral	0.27	neutral	2.13	neutral	-2.9	deleterious	-3.41	medium_impact	3.26	0.55	damaging	0.41	neutral	3.82	23.40	deleterious	0.23	0.45	NA	NA	0.39	neutral	0.49	neutral	0.19	neutral	6	0.94	neutral	0.17	neutral	1	deleterious	0.89	deleterious	-1.96	low_impact	-0.06	medium_impact	1.74	medium_impact	0.43	0.8	NA	NA	0.44	N	0.94	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9988	9988	C	T	MI.8312	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	782	261	S	F	tCt/tTt	7.3	1	0	probably_damaging	0.99	neutral	0.11	neutral	2.13	deleterious	-3.58	deleterious	-4.1	low_impact	1.88	0.59	damaging	0.43	neutral	4.31	24.00	deleterious	0.21	0.45	NA	NA	0.44	neutral	0.5	neutral	0.24	neutral	5	0.99	deleterious	0.06	neutral	-2	neutral	0.93	deleterious	-2.81	low_impact	-0.33	medium_impact	0.5	medium_impact	0.11	0.8	NA	NA	0.54	P	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9988	9988	C	G	MI.8313	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	782	261	S	C	tCt/tGt	7.3	1	0	probably_damaging	0.98	neutral	0.12	neutral	2.11	deleterious	-3.71	deleterious	-3.3	medium_impact	2.23	0.59	damaging	0.39	neutral	3.63	23.20	deleterious	0.24	0.45	NA	NA	0.29	neutral	0.43	neutral	0.19	neutral	6	0.99	deleterious	0.07	neutral	1	deleterious	0.93	deleterious	-2.51	low_impact	-0.3	medium_impact	0.82	medium_impact	0.28	0.8	NA	NA	0.59	P	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	9988	9988	C	A	MI.8314	MT-CO3	IV	ENSG00000198938	ENSP00000354982	ENST00000362079	COX3_HUMAN	P00414	4514	YP_003024032.1	782	261	S	Y	tCt/tAt	7.3	1	0	probably_damaging	0.99	neutral	0.13	neutral	2.17	deleterious	-3.7	deleterious	-4	low_impact	1.4	0.59	damaging	0.32	neutral	4.17	23.80	deleterious	0.23	0.45	NA	NA	0.43	neutral	0.52	disease	0.39	neutral	2	0.99	deleterious	0.07	neutral	-2	neutral	0.93	deleterious	-2.81	low_impact	-0.28	medium_impact	0.07	medium_impact	0.28	0.8	NA	NA	0.51	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14747	14747	A	C	MI.8315	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1	1	M	L	Atg/Ctg	2.02	0.8	0	possibly_damaging	0.75	deleterious	0	neutral	4.79	neutral	1.23	neutral	-1.02	NA	NA	0.89	neutral	0.07	damaging	1.34	12.49	neutral	0.09	0.35	0.21	neutral	0.16	neutral	0.26	neutral	0.3	neutral	4	1	deleterious	0.13	neutral	3	deleterious	0.52	deleterious	NA	NA	NA	NA	NA	NA	0.16	0.8	57.37	8.8	0.38	N	0.93	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14747	14747	A	T	MI.8316	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1	1	M	L	Atg/Ttg	2.02	0.8	0	possibly_damaging	0.75	deleterious	0	neutral	4.79	neutral	1.23	neutral	-1.02	NA	NA	0.89	neutral	0.07	damaging	1.39	12.71	neutral	0.09	0.35	0.21	neutral	0.16	neutral	0.26	neutral	0.3	neutral	4	1	deleterious	0.13	neutral	3	deleterious	0.52	deleterious	NA	NA	NA	NA	NA	NA	0.16	0.8	57.37	8.8	0.38	N	0.93	NA	NA	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14747	14747	A	G	MI.8317	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	1	1	M	V	Atg/Gtg	2.02	0.8	0	possibly_damaging	0.83	deleterious	0	neutral	4.68	neutral	0.74	neutral	-1.23	NA	NA	0.84	neutral	0.09	damaging	0.73	9.05	deleterious	0.14	0.4	0.17	neutral	0.21	neutral	0.43	neutral	0.36	neutral	3	1	deleterious	0.09	neutral	3	deleterious	0.57	deleterious	NA	NA	NA	NA	NA	NA	0.17	0.8	57.37	8.8	0.32	N	0.99	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14748	14748	T	A	MI.8318	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	2	1	M	K	aTg/aAg	6.38	1	0	probably_damaging	0.92	deleterious	0	neutral	4.59	neutral	-0.31	neutral	-1.93	NA	NA	0.87	neutral	0.07	damaging	2.02	16.35	deleterious	0.1	0.4	0.33	neutral	0.36	neutral	0.6	disease	0.44	neutral	1	1	deleterious	0.04	neutral	4	deleterious	0.73	deleterious	NA	NA	NA	NA	NA	NA	0.06	0.8	57.37	8.8	0.54	P	0.99	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14748	14748	T	C	MI.8319	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	2	1	M	T	aTg/aCg	6.38	1	0	probably_damaging	0.92	deleterious	0	neutral	4.59	neutral	-0.39	neutral	-1.48	NA	NA	0.88	neutral	0.09	damaging	0.88	9.94	deleterious	0.11	0.4	0.29	neutral	0.32	neutral	0.46	neutral	0.41	neutral	2	1	deleterious	0.04	neutral	4	deleterious	0.73	deleterious	NA	NA	NA	NA	NA	NA	0.03	0.8	57.37	8.8	0.52	P	0.99	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8917	8917	C	A	MI.832	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	391	131	Q	K	Caa/Aaa	-4.5	0	0	probably_damaging	0.97	neutral	0.53	neutral	4.39	neutral	-0.05	deleterious	-2.52	low_impact	1.82	0.82	neutral	0.14	damaging	3.97	23.60	deleterious	0.57	0.65	0.37	neutral	0.67	disease	0.47	neutral	0.41	neutral	2	0.97	neutral	0.28	neutral	-2	neutral	0.71	deleterious	-2.19	low_impact	0.32	medium_impact	0.46	medium_impact	0.59	0.9	44.69	8.63	0.18	N	0.99	polymorphism	0.97	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14749	14749	G	T	MI.8320	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	3	1	M	I	atG/atT	7.07	1	0	possibly_damaging	0.88	deleterious	0	neutral	4.68	neutral	0.61	neutral	-1.33	NA	NA	0.89	neutral	0.06	damaging	1.60	13.87	neutral	0.11	0.4	0.19	neutral	0.21	neutral	0.4	neutral	0.34	neutral	3	1	deleterious	0.06	neutral	3	deleterious	0.65	deleterious	NA	NA	NA	NA	NA	NA	0.25	0.8	57.37	8.8	0.55	P	0.99	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14749	14749	G	C	MI.8321	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	3	1	M	I	atG/atC	7.07	1	0	possibly_damaging	0.88	deleterious	0	neutral	4.68	neutral	0.61	neutral	-1.33	NA	NA	0.89	neutral	0.06	damaging	1.44	13.01	neutral	0.11	0.4	0.19	neutral	0.21	neutral	0.4	neutral	0.34	neutral	3	1	deleterious	0.06	neutral	3	deleterious	0.65	deleterious	NA	NA	NA	NA	NA	NA	0.25	0.8	57.37	8.8	0.55	P	0.99	NA	NA	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14750	14750	A	C	MI.8322	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	4	2	T	P	Acc/Ccc	6.84	1	0.01	benign	0.12	neutral	0.36	neutral	4.57	neutral	-1.01	neutral	-1.68	medium_impact	2.74	0.96	neutral	0.3	neutral	1.44	13.01	neutral	0.15	0.45	0.17	neutral	0.33	neutral	0.08	neutral	0.46	neutral	1	0.58	neutral	0.62	deleterious	-3	neutral	0.32	neutral	0.08	medium_impact	0.09	medium_impact	1.29	medium_impact	0.28	0.8	44.74	8.4	0.6	P	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14750	14750	A	G	MI.8323	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	4	2	T	A	Acc/Gcc	6.84	1	0.01	benign	0	neutral	1	neutral	4.75	neutral	-0.19	neutral	-0.8	low_impact	0.83	0.98	neutral	0.71	neutral	0.00	2.58	deleterious	0.44	0.55	0.26	neutral	0.02	neutral	0.07	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.05	neutral	2.07	high_impact	1.85	high_impact	-0.44	medium_impact	0.18	0.8	44.74	8.4	0.53	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14750	14750	A	T	MI.8324	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	4	2	T	S	Acc/Tcc	6.84	1	0.01	benign	0.01	neutral	0.71	neutral	4.67	neutral	0.05	neutral	-0.95	medium_impact	2.6	0.96	neutral	0.47	neutral	1.17	11.60	neutral	0.62	0.65	0.31	neutral	0.13	neutral	0.06	neutral	0.28	neutral	4	0.27	neutral	0.85	deleterious	-3	neutral	0.08	neutral	1.13	medium_impact	0.43	medium_impact	1.17	medium_impact	0.52	0.8	44.74	8.4	0.53	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14751	14751	C	T	MI.8325	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	5	2	T	I	aCc/aTc	1.33	0.99	0.01	benign	0.1	neutral	0.47	neutral	4.62	neutral	-2.6	neutral	-1.43	medium_impact	2.62	0.95	neutral	0.66	neutral	1.96	15.95	deleterious	0.34	0.5	0.26	neutral	0.22	neutral	0.21	neutral	0.43	neutral	2	0.46	neutral	0.69	deleterious	-3	neutral	0.27	neutral	0.16	medium_impact	0.19	medium_impact	1.19	medium_impact	0.24	0.8	44.74	8.4	0.51	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14751	14751	C	G	MI.8326	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	5	2	T	S	aCc/aGc	1.33	0.99	0.01	benign	0.01	neutral	0.71	neutral	4.67	neutral	0.05	neutral	-0.95	medium_impact	2.6	0.96	neutral	0.47	neutral	1.36	12.58	neutral	0.62	0.65	0.31	neutral	0.13	neutral	0.06	neutral	0.28	neutral	4	0.27	neutral	0.85	deleterious	-3	neutral	0.08	neutral	1.13	medium_impact	0.43	medium_impact	1.17	medium_impact	0.52	0.8	44.74	8.4	0.43	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14751	14751	C	A	MI.8327	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	5	2	T	N	aCc/aAc	1.33	0.99	0.01	benign	0.12	neutral	0.58	neutral	4.6	neutral	0.13	neutral	-1.35	medium_impact	3.43	0.96	neutral	0.63	neutral	1.57	13.67	neutral	0.54	0.6	0.43	neutral	0.23	neutral	0.09	neutral	0.44	neutral	1	0.32	neutral	0.73	deleterious	-3	neutral	0.23	neutral	0.08	medium_impact	0.3	medium_impact	1.92	medium_impact	0.32	0.8	44.74	8.4	0.43	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14753	14753	C	A	MI.8328	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	7	3	P	T	Cca/Aca	-2.11	0	0	benign	0.31	neutral	0.72	neutral	4.74	neutral	0.28	neutral	0.14	low_impact	0.92	0.95	neutral	0.74	neutral	2.18	17.37	deleterious	0.33	0.5	0.3	neutral	0.09	neutral	0.15	neutral	0.33	neutral	3	0.22	neutral	0.71	deleterious	-6	neutral	0.23	neutral	-0.41	medium_impact	0.44	medium_impact	-0.36	medium_impact	0.44	0.8	25.53	51.21	0.4	N	0.36	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14753	14753	C	T	MI.8329	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	7	3	P	S	Cca/Tca	-2.11	0	0	benign	0.02	neutral	0.92	neutral	4.78	neutral	0.16	neutral	0.43	neutral_impact	-0.06	0.94	neutral	0.78	neutral	2.04	16.45	deleterious	0.41	0.5	0.24	neutral	0.05	neutral	0.11	neutral	0.27	neutral	5	0.03	neutral	0.95	deleterious	-6	neutral	0.07	neutral	0.85	medium_impact	0.8	medium_impact	-1.25	low_impact	0.32	0.8	25.53	51.21	0.37	N	0.01	polymorphism	1	0.01	rs527236162	Likely_pathogenic	Neoplasm_of_ovary	153590	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	8917	8917	C	G	MI.833	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	391	131	Q	E	Caa/Gaa	-4.5	0	0	probably_damaging	0.94	neutral	1	neutral	4.37	neutral	-0.2	neutral	-0.61	neutral_impact	-0.48	0.77	neutral	0.56	neutral	0.38	6.41	deleterious	0.62	0.7	0.31	neutral	0.08	neutral	0.19	neutral	0.29	neutral	4	0.94	neutral	0.53	deleterious	-2	neutral	0.63	deleterious	-1.89	low_impact	1.98	high_impact	-1.51	low_impact	0.59	0.9	44.69	8.63	0.32	N	0.94	polymorphism	0.98	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14753	14753	C	G	MI.8330	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	7	3	P	A	Cca/Gca	-2.11	0	0	benign	0.14	neutral	0.93	neutral	4.77	neutral	0.48	neutral	-0.29	low_impact	1.38	0.95	neutral	0.71	neutral	2.55	19.78	deleterious	0.37	0.5	0.17	neutral	0.06	neutral	0.3	neutral	0.27	neutral	5	0.05	neutral	0.9	deleterious	-6	neutral	0.14	neutral	0	medium_impact	0.83	medium_impact	0.06	medium_impact	0.59	0.8	25.53	51.21	0.35	N	0.43	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14754	14754	C	T	MI.8331	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	8	3	P	L	cCa/cTa	1.33	0	0	possibly_damaging	0.52	neutral	0.89	neutral	4.72	neutral	1.03	neutral	-0.56	low_impact	1.82	0.95	neutral	0.53	neutral	4.01	23.60	deleterious	0.27	0.45	0.4	neutral	0.12	neutral	0.39	neutral	0.35	neutral	3	0.44	neutral	0.69	deleterious	-3	neutral	0.33	neutral	-0.76	medium_impact	0.71	medium_impact	0.46	medium_impact	0.50	0.8	25.53	51.21	0.29	N	0.59	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14754	14754	C	G	MI.8332	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	8	3	P	R	cCa/cGa	1.33	0	0	possibly_damaging	0.71	neutral	0.63	neutral	4.72	neutral	-0.02	neutral	-0.35	low_impact	1.82	0.95	neutral	0.48	neutral	3.32	22.90	deleterious	0.23	0.45	0.31	neutral	0.26	neutral	0.4	neutral	0.45	neutral	1	0.65	neutral	0.46	neutral	-3	neutral	0.46	deleterious	-1.09	low_impact	0.35	medium_impact	0.46	medium_impact	0.32	0.8	25.53	51.21	0.31	N	0.48	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14754	14754	C	A	MI.8333	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	8	3	P	Q	cCa/cAa	1.33	0	0	possibly_damaging	0.7	neutral	0.62	neutral	4.72	neutral	-0.49	neutral	-0.17	low_impact	1.73	0.95	neutral	0.53	neutral	3.83	23.40	deleterious	0.26	0.45	0.2	neutral	0.14	neutral	0.4	neutral	0.33	neutral	3	0.65	neutral	0.46	neutral	-3	neutral	0.44	deleterious	-1.07	low_impact	0.34	medium_impact	0.38	medium_impact	0.32	0.8	25.53	51.21	0.35	N	0.39	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14756	14756	A	C	MI.8334	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	10	4	M	L	Ata/Cta	-0.04	0	0	benign	0	neutral	0.44	neutral	4.9	neutral	1.96	neutral	0.14	neutral_impact	-0.94	0.98	neutral	0.93	neutral	-1.04	0.01	neutral	0.32	0.5	0.19	neutral	0.04	neutral	0.22	neutral	0.2	neutral	6	0.56	neutral	0.72	deleterious	-6	neutral	0.05	neutral	2.07	high_impact	0.17	medium_impact	-2.05	low_impact	0.09	0.8	26.32	48.86	0.49	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14756	14756	A	T	MI.8335	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	10	4	M	L	Ata/Tta	-0.04	0	0	benign	0	neutral	0.44	neutral	4.9	neutral	1.96	neutral	0.14	neutral_impact	-0.94	0.98	neutral	0.93	neutral	-0.90	0.03	neutral	0.32	0.5	0.19	neutral	0.04	neutral	0.22	neutral	0.2	neutral	6	0.56	neutral	0.72	deleterious	-6	neutral	0.05	neutral	2.07	high_impact	0.17	medium_impact	-2.05	low_impact	0.09	0.8	26.32	48.86	0.5	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14756	14756	A	G	MI.8336	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	10	4	M	V	Ata/Gta	-0.04	0	0	benign	0.01	neutral	0.37	neutral	4.79	neutral	1.31	neutral	-0.52	medium_impact	2.05	0.97	neutral	0.7	neutral	0.85	9.76	deleterious	0.38	0.5	0.22	neutral	0.18	neutral	0.36	neutral	0.34	neutral	3	0.62	neutral	0.68	deleterious	-3	neutral	0.08	neutral	1.13	medium_impact	0.1	medium_impact	0.67	medium_impact	0.09	0.8	26.32	48.86	0.41	N	0.22	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14757	14757	T	C	MI.8337	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	11	4	M	T	aTa/aCa	0.64	0	0	benign	0	neutral	0.62	neutral	4.71	neutral	-0.12	neutral	-1.13	neutral_impact	0.69	0.99	neutral	0.97	neutral	-0.28	0.72	neutral	0.22	0.45	0.29	neutral	0.17	neutral	0.4	neutral	0.31	neutral	4	0.38	neutral	0.81	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.34	medium_impact	-0.57	medium_impact	0.04	0.8	26.32	48.86	0.39	N	0.01	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14757	14757	T	A	MI.8338	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	11	4	M	K	aTa/aAa	0.64	0	0	benign	0.03	neutral	0.94	neutral	4.68	neutral	-0.32	neutral	-1.79	medium_impact	2.46	0.95	neutral	0.49	neutral	2.16	17.23	deleterious	0.17	0.45	0.48	neutral	0.38	neutral	0.67	disease	0.48	neutral	0	0.01	neutral	0.96	deleterious	-3	neutral	0.16	neutral	0.68	medium_impact	0.87	medium_impact	1.04	medium_impact	0.11	0.8	26.32	48.86	0.25	N	0.48	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14758	14758	A	C	MI.8339	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	12	4	M	I	atA/atC	1.56	0	0	benign	0.01	neutral	0.27	neutral	4.8	neutral	1.29	neutral	-0.3	neutral_impact	-0.28	0.96	neutral	0.97	neutral	-1.23	0.01	neutral	0.3	0.45	0.15	neutral	0.05	neutral	0.21	neutral	0.24	neutral	5	0.73	neutral	0.63	deleterious	-6	neutral	0.06	neutral	1.13	medium_impact	-0.01	medium_impact	-1.45	low_impact	0.14	0.8	26.32	48.86	0.5	N	0.01	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8918	8918	A	C	MI.834	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	392	131	Q	P	cAa/cCa	4.52	1	0	probably_damaging	0.98	neutral	0.18	neutral	4.43	neutral	0.36	deleterious	-4.35	low_impact	1.86	0.69	neutral	0.17	damaging	3.24	22.80	deleterious	0.19	0.65	0.68	disease	0.83	disease	0.43	neutral	0.67	disease	3	0.99	deleterious	0.1	neutral	-2	neutral	0.83	deleterious	-2.36	low_impact	-0.08	medium_impact	0.5	medium_impact	0.41	0.9	44.69	8.63	0.37	N	0.98	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14758	14758	A	T	MI.8340	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	12	4	M	I	atA/atT	1.56	0	0	benign	0.01	neutral	0.27	neutral	4.8	neutral	1.29	neutral	-0.3	neutral_impact	-0.28	0.96	neutral	0.97	neutral	-1.16	0.01	neutral	0.3	0.45	0.15	neutral	0.05	neutral	0.21	neutral	0.24	neutral	5	0.73	neutral	0.63	deleterious	-6	neutral	0.06	neutral	1.13	medium_impact	-0.01	medium_impact	-1.45	low_impact	0.14	0.8	26.32	48.86	0.51	P	0.01	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14759	14759	C	A	MI.8341	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	13	5	R	S	Cgc/Agc	-11.28	0	0	probably_damaging	0.95	neutral	0.44	neutral	4.6	neutral	-0.35	deleterious	-3.01	high_impact	4.29	0.95	neutral	0.34	neutral	2.63	20.40	deleterious	0.09	0.4	0.54	disease	0.52	disease	0.64	disease	0.65	disease	3	0.95	neutral	0.25	neutral	2	deleterious	0.74	deleterious	-1.92	low_impact	0.17	medium_impact	2.7	high_impact	0.22	0.8	58.95	8.56	0.4	N	0.77	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14759	14759	C	G	MI.8342	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	13	5	R	G	Cgc/Ggc	-11.28	0	0	probably_damaging	0.95	neutral	0.34	neutral	4.54	neutral	-1.47	deleterious	-3.51	high_impact	3.81	0.96	neutral	0.36	neutral	2.24	17.78	deleterious	0.1	0.4	0.69	disease	0.42	neutral	0.67	disease	0.58	disease	2	0.95	neutral	0.2	neutral	2	deleterious	0.74	deleterious	-1.92	low_impact	0.07	medium_impact	2.27	high_impact	0.13	0.8	58.95	8.56	0.41	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14759	14759	C	T	MI.8343	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	13	5	R	C	Cgc/Tgc	-11.28	0	0	probably_damaging	0.99	neutral	0.18	neutral	4.51	deleterious	-3.22	deleterious	-4.01	high_impact	4.84	0.95	neutral	0.17	damaging	3.33	22.90	deleterious	0.08	0.35	0.89	disease	0.53	disease	0.7	disease	0.74	disease	5	0.99	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	-0.14	medium_impact	3.2	high_impact	0.57	0.8	58.95	8.56	0.64	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14760	14760	G	T	MI.8344	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	14	5	R	L	cGc/cTc	1.56	0.54	0	possibly_damaging	0.89	neutral	0.69	neutral	4.6	neutral	0.04	deleterious	-3.47	high_impact	3.52	0.94	neutral	0.27	damaging	2.35	18.52	deleterious	0.11	0.4	0.63	disease	0.61	disease	0.65	disease	0.66	disease	3	0.87	neutral	0.4	neutral	1	deleterious	0.75	deleterious	-1.58	low_impact	0.41	medium_impact	2	high_impact	0.01	0.8	58.95	8.56	0.27	N	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14760	14760	G	A	MI.8345	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	14	5	R	H	cGc/cAc	1.56	0.54	0	probably_damaging	0.97	neutral	0.55	neutral	4.53	neutral	-1.8	deleterious	-2.52	medium_impact	3.46	0.93	neutral	0.21	damaging	2.59	20.10	deleterious	0.23	0.45	0.4	neutral	0.48	neutral	0.55	disease	0.51	disease	0	0.97	neutral	0.29	neutral	1	deleterious	0.73	deleterious	-2.14	low_impact	0.27	medium_impact	1.95	medium_impact	0.48	0.8	58.95	8.56	0.27	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14760	14760	G	C	MI.8346	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	14	5	R	P	cGc/cCc	1.56	0.54	0	probably_damaging	0.98	neutral	0.21	neutral	4.53	neutral	-1.75	deleterious	-3.51	medium_impact	3.46	0.93	neutral	0.21	damaging	2.38	18.68	deleterious	0.05	0.35	0.61	disease	0.58	disease	0.66	disease	0.67	disease	3	0.99	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-2.31	low_impact	-0.09	medium_impact	1.95	medium_impact	0.15	0.8	58.95	8.56	0.36	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14762	14762	A	G	MI.8347	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	16	6	K	E	Aaa/Gaa	-2.8	0	0	probably_damaging	0.95	neutral	0.69	neutral	4.42	neutral	-1.7	neutral	-2.08	medium_impact	3.12	0.86	neutral	0.4	neutral	2.19	17.41	deleterious	0.24	0.45	0.49	neutral	0.62	disease	0.67	disease	0.68	disease	4	0.94	neutral	0.37	neutral	1	deleterious	0.76	deleterious	-1.92	low_impact	0.41	medium_impact	1.64	medium_impact	0.53	0.8	58.95	8.87	0.2	N	0.95	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14762	14762	A	C	MI.8348	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	16	6	K	Q	Aaa/Caa	-2.8	0	0	probably_damaging	0.95	neutral	0.52	neutral	4.4	neutral	-1.92	neutral	-2.08	high_impact	3.75	0.96	neutral	0.44	neutral	1.59	13.80	neutral	0.39	0.5	0.54	disease	0.58	disease	0.5	neutral	0.5	disease	0	0.94	neutral	0.29	neutral	2	deleterious	0.73	deleterious	-1.92	low_impact	0.24	medium_impact	2.21	high_impact	0.37	0.8	58.95	8.87	0.32	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14763	14763	A	C	MI.8349	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	17	6	K	T	aAa/aCa	8.44	1	0	probably_damaging	0.98	neutral	0.64	neutral	4.37	neutral	-2.44	deleterious	-3.12	high_impact	4.18	0.93	neutral	0.45	neutral	1.94	15.83	deleterious	0.09	0.4	0.58	disease	0.6	disease	0.55	disease	0.54	disease	1	0.98	deleterious	0.33	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0.36	medium_impact	2.6	high_impact	0.18	0.8	58.95	8.87	0.55	P	0.88	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8918	8918	A	G	MI.835	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	392	131	Q	R	cAa/cGa	4.52	1	0	probably_damaging	0.97	neutral	0.21	neutral	4.3	neutral	-1.24	deleterious	-2.86	medium_impact	2.6	0.86	neutral	0.15	damaging	3.34	22.90	deleterious	0.56	0.65	0.48	neutral	0.73	disease	0.58	disease	0.69	disease	4	0.98	deleterious	0.12	neutral	1	deleterious	0.78	deleterious	-2.19	low_impact	-0.03	medium_impact	1.13	medium_impact	0.36	0.9	44.69	8.63	0.42	N	0.91	disease_causing	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14763	14763	A	T	MI.8350	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	17	6	K	M	aAa/aTa	8.44	1	0	probably_damaging	0.99	neutral	0.26	neutral	4.32	deleterious	-4.03	deleterious	-3.12	high_impact	4.43	0.96	neutral	0.46	neutral	3.63	23.20	deleterious	0.1	0.4	0.79	disease	0.61	disease	0.64	disease	0.69	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.76	deleterious	-2.59	low_impact	-0.02	medium_impact	2.83	high_impact	0.17	0.8	58.95	8.87	0.64	P	0.67	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14764	14764	A	T	MI.8351	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	18	6	K	N	aaA/aaT	6.61	1	0	probably_damaging	0.99	neutral	0.59	neutral	4.38	neutral	-2.46	deleterious	-2.6	medium_impact	3.16	0.93	neutral	0.43	neutral	2.23	17.69	deleterious	0.46	0.55	0.44	neutral	0.53	disease	0.53	disease	0.57	disease	1	0.99	deleterious	0.3	neutral	1	deleterious	0.74	deleterious	-2.59	low_impact	0.31	medium_impact	1.68	medium_impact	0.36	0.8	58.95	8.87	0.52	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14764	14764	A	C	MI.8352	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	18	6	K	N	aaA/aaC	6.61	1	0	probably_damaging	0.99	neutral	0.59	neutral	4.38	neutral	-2.46	deleterious	-2.6	medium_impact	3.16	0.93	neutral	0.43	neutral	2.20	17.48	deleterious	0.46	0.55	0.44	neutral	0.53	disease	0.53	disease	0.57	disease	1	0.99	deleterious	0.3	neutral	1	deleterious	0.74	deleterious	-2.59	low_impact	0.31	medium_impact	1.68	medium_impact	0.36	0.8	58.95	8.87	0.51	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14765	14765	A	C	MI.8353	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	19	7	T	P	Act/Cct	2.48	0.98	0	benign	0.4	neutral	0.29	neutral	4.6	neutral	-1.16	neutral	-2.38	NA	NA	0.99	neutral	0.36	neutral	1.44	12.99	neutral	0.04	0.35	0.39	neutral	0.65	disease	0.61	disease	0.66	disease	3	0.66	neutral	0.45	neutral	-4	neutral	0.46	deleterious	NA	NA	NA	NA	NA	NA	0.33	0.8	17.89	14.22	0.5	N	0.61	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14765	14765	A	G	MI.8354	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	19	7	T	A	Act/Gct	2.48	0.98	0	benign	0.01	neutral	0.69	neutral	4.68	neutral	-0.54	neutral	-1.74	NA	NA	0.99	neutral	0.63	neutral	1.37	12.62	neutral	0.25	0.45	0.17	neutral	0.27	neutral	0.53	disease	0.46	neutral	1	0.3	neutral	0.84	deleterious	-4	neutral	0.07	neutral	NA	NA	NA	NA	NA	NA	0.20	0.8	17.89	14.22	0.41	N	0.10	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14765	14765	A	T	MI.8355	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	19	7	T	S	Act/Tct	2.48	0.98	0	benign	0.11	neutral	0.72	neutral	4.71	neutral	-0.05	neutral	-1.05	NA	NA	0.97	neutral	0.97	neutral	-1.03	0.01	neutral	0.37	0.5	0.27	neutral	0.11	neutral	0.3	neutral	0.26	neutral	5	0.17	neutral	0.81	deleterious	-4	neutral	0.11	neutral	NA	NA	NA	NA	NA	NA	0.55	0.8	17.89	14.22	0.5	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14766	14766	C	A	MI.8356	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	20	7	T	N	aCt/aAt	-0.04	0	0.83	possibly_damaging	0.48	neutral	0.54	neutral	4.65	neutral	-0.53	neutral	-1.63	NA	NA	0.96	neutral	0.87	neutral	0.65	8.49	deleterious	0.43	0.55	0.21	neutral	0.4	neutral	0.41	neutral	0.43	neutral	1	0.45	neutral	0.53	deleterious	-1	neutral	0.41	neutral	NA	NA	NA	NA	NA	NA	0.50	0.8	17.89	14.22	0.33	N	0.04	polymorphism	1	0.02	rs193302980	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	14766	14766	C	T	MI.8357	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	20	7	T	I	aCt/aTt	-0.04	0	0.83	benign	0.01	neutral	0.21	neutral	4.61	neutral	-1.54	neutral	-2.35	NA	NA	0.98	neutral	0.62	neutral	1.93	15.79	deleterious	0.12	0.4	0.17	neutral	0.52	disease	0.6	disease	0.48	neutral	0	0.79	neutral	0.6	deleterious	-4	neutral	0.09	neutral	NA	NA	NA	NA	NA	NA	0.32	0.8	17.89	14.22	0.48	N	0.09	polymorphism	1	0.08	rs193302980,rs527236041	Likely_pathogenic	Familial_cancer_of_breast	150279	MedGen:C0346153,OMIM:114480,Orphanet:ORPHA227535,SNOMED_CT:254843006	.	.	.	0.74	.	.	.	.	.	.	P	.	P	damaging
chrM	14766	14766	C	G	MI.8358	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	20	7	T	S	aCt/aGt	-0.04	0	0.83	benign	0.11	neutral	0.72	neutral	4.71	neutral	-0.05	neutral	-1.05	NA	NA	0.97	neutral	0.97	neutral	-0.64	0.10	neutral	0.37	0.5	0.27	neutral	0.11	neutral	0.3	neutral	0.26	neutral	5	0.17	neutral	0.81	deleterious	-4	neutral	0.11	neutral	NA	NA	NA	NA	NA	NA	0.55	0.8	17.89	14.22	0.39	N	0.00	polymorphism	1	0.02	rs193302980	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	14768	14768	A	G	MI.8359	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	22	8	N	D	Aac/Gac	-8.99	0	0	probably_damaging	0.98	neutral	0.33	neutral	4.65	neutral	-0.78	neutral	-1.38	low_impact	0.99	0.95	neutral	0.55	neutral	2.00	16.20	deleterious	0.43	0.55	0.39	neutral	0.35	neutral	0.67	disease	0.46	neutral	1	0.98	deleterious	0.18	neutral	-2	neutral	0.69	deleterious	-2.31	low_impact	0.06	medium_impact	-0.29	medium_impact	0.33	0.8	21.32	58.66	0.34	N	0.67	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8918	8918	A	T	MI.836	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	392	131	Q	L	cAa/cTa	4.52	1	0	probably_damaging	0.97	neutral	0.37	neutral	4.29	neutral	-1.52	deleterious	-5.44	low_impact	1.24	0.89	neutral	0.69	neutral	3.63	23.20	deleterious	0.52	0.65	0.3	neutral	0.56	disease	0.38	neutral	0.34	neutral	3	0.97	neutral	0.2	neutral	-2	neutral	0.71	deleterious	-2.19	low_impact	0.16	medium_impact	-0.04	medium_impact	0.26	0.9	44.69	8.63	0.51	N	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14768	14768	A	C	MI.8360	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	22	8	N	H	Aac/Cac	-8.99	0	0	probably_damaging	1	neutral	0.59	neutral	4.7	neutral	0.62	neutral	2.67	neutral_impact	-2.67	0.93	neutral	0.93	neutral	-0.06	2.07	deleterious	0.27	0.45	0.18	neutral	0.04	neutral	0.36	neutral	0.17	neutral	7	1	deleterious	0.3	neutral	-2	neutral	0.61	deleterious	-3.53	low_impact	0.31	medium_impact	-3.62	low_impact	0.20	0.8	21.32	58.66	0.31	N	0.03	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14768	14768	A	T	MI.8361	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	22	8	N	Y	Aac/Tac	-8.99	0	0	probably_damaging	1	neutral	1	neutral	4.61	neutral	0.4	neutral	-0.28	neutral_impact	0.49	0.97	neutral	0.7	neutral	3.31	22.90	deleterious	0.12	0.4	0.63	disease	0.36	neutral	0.66	disease	0.62	disease	2	1	deleterious	0.5	deleterious	-2	neutral	0.75	deleterious	-3.53	low_impact	1.85	high_impact	-0.75	medium_impact	0.20	0.8	21.32	58.66	0.25	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14769	14769	A	T	MI.8362	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	23	8	N	I	aAc/aTc	2.71	0.99	0	probably_damaging	1	neutral	0.44	neutral	4.64	neutral	0.71	deleterious	-2.62	neutral_impact	0.64	0.96	neutral	0.59	neutral	3.52	23.10	deleterious	0.13	0.4	0.29	neutral	0.49	neutral	0.65	disease	0.59	disease	2	1	deleterious	0.22	neutral	-2	neutral	0.70	deleterious	-3.53	low_impact	0.17	medium_impact	-0.61	medium_impact	0.21	0.8	21.32	58.66	0.41	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14769	14769	A	C	MI.8363	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	23	8	N	T	aAc/aCc	2.71	0.99	0	probably_damaging	0.99	neutral	0.52	neutral	4.67	neutral	0.27	neutral	-1.9	low_impact	1.29	0.96	neutral	0.65	neutral	1.58	13.76	neutral	0.22	0.45	0.39	neutral	0.29	neutral	0.66	disease	0.44	neutral	1	0.99	deleterious	0.27	neutral	-2	neutral	0.68	deleterious	-2.59	low_impact	0.24	medium_impact	-0.02	medium_impact	0.31	0.8	21.32	58.66	0.42	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14769	14769	A	G	MI.8364	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	23	8	N	S	aAc/aGc	2.71	0.99	0	probably_damaging	0.98	neutral	0.58	neutral	4.69	neutral	0.07	neutral	-1.35	low_impact	0.87	0.97	neutral	0.66	neutral	1.25	11.99	neutral	0.38	0.5	0.34	neutral	0.25	neutral	0.6	disease	0.43	neutral	1	0.98	deleterious	0.3	neutral	-2	neutral	0.67	deleterious	-2.31	low_impact	0.3	medium_impact	-0.4	medium_impact	0.20	0.8	21.32	58.66	0.34	N	0.27	polymorphism	1	0.02	rs28357679	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14770	14770	C	A	MI.8365	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	24	8	N	K	aaC/aaA	5.46	1	0	probably_damaging	0.99	neutral	0.5	neutral	4.71	neutral	-0.13	neutral	-1.47	low_impact	1.22	0.96	neutral	0.54	neutral	2.67	20.60	deleterious	0.29	0.45	0.29	neutral	0.42	neutral	0.69	disease	0.46	neutral	1	0.99	deleterious	0.26	neutral	-2	neutral	0.69	deleterious	-2.59	low_impact	0.22	medium_impact	-0.09	medium_impact	0.30	0.8	21.32	58.66	0.5	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14770	14770	C	G	MI.8366	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	24	8	N	K	aaC/aaG	5.46	1	0	probably_damaging	0.99	neutral	0.5	neutral	4.71	neutral	-0.13	neutral	-1.47	low_impact	1.22	0.96	neutral	0.54	neutral	2.23	17.74	deleterious	0.29	0.45	0.29	neutral	0.42	neutral	0.69	disease	0.46	neutral	1	0.99	deleterious	0.26	neutral	-2	neutral	0.69	deleterious	-2.59	low_impact	0.22	medium_impact	-0.09	medium_impact	0.30	0.8	21.32	58.66	0.5	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14771	14771	C	T	MI.8367	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	25	9	P	S	Ccc/Tcc	-0.04	0.87	0	probably_damaging	0.98	neutral	0.41	neutral	4.55	neutral	-1.09	deleterious	-4.38	high_impact	3.63	0.92	neutral	0.11	damaging	1.88	15.45	deleterious	0.14	0.4	0.41	neutral	0.73	disease	0.52	disease	0.54	disease	1	0.98	neutral	0.22	neutral	2	deleterious	0.76	deleterious	-2.31	low_impact	0.14	medium_impact	2.1	high_impact	0.14	0.8	24.21	8.33	0.35	N	0.85	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14771	14771	C	G	MI.8368	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	25	9	P	A	Ccc/Gcc	-0.04	0.87	0	probably_damaging	0.91	neutral	0.5	neutral	4.55	neutral	-1.11	deleterious	-4.39	high_impact	3.68	0.94	neutral	0.15	damaging	1.02	10.80	neutral	0.14	0.4	0.3	neutral	0.56	disease	0.61	disease	0.64	disease	3	0.9	neutral	0.3	neutral	2	deleterious	0.69	deleterious	-1.67	low_impact	0.22	medium_impact	2.15	high_impact	0.33	0.8	24.21	8.33	0.34	N	0.82	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14771	14771	C	A	MI.8369	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	25	9	P	T	Ccc/Acc	-0.04	0.87	0	probably_damaging	0.98	neutral	0.39	neutral	4.53	neutral	-1.52	deleterious	-4.39	high_impact	3.73	0.92	neutral	0.11	damaging	1.90	15.57	deleterious	0.14	0.4	0.44	neutral	0.77	disease	0.51	disease	0.61	disease	2	0.98	neutral	0.21	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0.12	medium_impact	2.19	high_impact	0.26	0.8	24.21	8.33	0.36	N	0.96	polymorphism	1	0.24	.	Uncertain_significance	Spinocerebellar_ataxia,_autosomal_recessive_20	361117	MedGen:C4225355,OMIM:616354,Orphanet:ORPHA397709	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8919	8919	A	C	MI.837	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	393	131	Q	H	caA/caC	5.68	1	0	probably_damaging	1	neutral	0.05	neutral	4.3	neutral	-1.33	deleterious	-3.38	medium_impact	2.04	0.81	neutral	0.16	damaging	3.42	23.00	deleterious	0.64	0.7	0.64	disease	0.52	disease	0.46	neutral	0.49	neutral	0	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.43	medium_impact	0.65	medium_impact	0.57	0.9	44.69	8.63	0.49	N	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14772	14772	C	A	MI.8370	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	26	9	P	H	cCc/cAc	4.31	0.99	0	probably_damaging	1	neutral	0.57	neutral	4.48	neutral	-2.85	deleterious	-4.94	high_impact	4.16	0.9	neutral	0.09	damaging	3.60	23.20	deleterious	0.09	0.35	0.66	disease	0.8	disease	0.66	disease	0.7	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.29	medium_impact	2.58	high_impact	0.17	0.8	24.21	8.33	0.46	N	0.71	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14772	14772	C	T	MI.8371	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	26	9	P	L	cCc/cTc	4.31	0.99	0	probably_damaging	1	neutral	0.67	neutral	4.52	neutral	-1.62	deleterious	-5.5	high_impact	3.81	0.94	neutral	0.13	damaging	3.83	23.40	deleterious	0.08	0.35	0.46	neutral	0.76	disease	0.59	disease	0.61	disease	2	0.99	deleterious	0.34	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.39	medium_impact	2.27	high_impact	0.63	0.8	24.21	8.33	0.43	N	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14772	14772	C	G	MI.8372	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	26	9	P	R	cCc/cGc	4.31	0.99	0	probably_damaging	1	neutral	0.36	neutral	4.55	neutral	-1.34	deleterious	-4.92	high_impact	3.77	0.93	neutral	0.08	damaging	3.18	22.70	deleterious	0.07	0.35	0.5	neutral	0.84	disease	0.69	disease	0.74	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.09	medium_impact	2.23	high_impact	0.19	0.8	24.21	8.33	0.46	N	0.81	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14774	14774	C	G	MI.8373	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	28	10	L	V	Cta/Gta	-6.47	0	0	possibly_damaging	0.84	neutral	0.58	neutral	4.5	neutral	-0.92	neutral	-0.9	low_impact	1.78	0.96	neutral	0.14	damaging	1.33	12.42	neutral	0.24	0.45	0.38	neutral	0.56	disease	0.29	neutral	0.46	neutral	1	0.82	neutral	0.37	neutral	-3	neutral	0.65	deleterious	-1.4	low_impact	0.3	medium_impact	0.42	medium_impact	0.57	0.8	21.05	43.58	0.23	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14774	14774	C	A	MI.8374	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	28	10	L	M	Cta/Ata	-6.47	0	0	probably_damaging	0.99	neutral	0.26	neutral	4.4	neutral	-2.36	neutral	-0.74	low_impact	1.94	0.95	neutral	0.12	damaging	1.86	15.35	deleterious	0.28	0.45	0.58	disease	0.52	disease	0.33	neutral	0.48	neutral	0	0.99	deleterious	0.14	neutral	-2	neutral	0.75	deleterious	-2.59	low_impact	-0.02	medium_impact	0.57	medium_impact	0.54	0.8	21.05	43.58	0.36	N	0.62	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14775	14775	T	C	MI.8375	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	29	10	L	P	cTa/cCa	-1.42	0	0	probably_damaging	1	neutral	0.36	neutral	4.35	deleterious	-4.06	deleterious	-3.32	medium_impact	3.4	0.95	neutral	0.06	damaging	3.48	23.10	deleterious	0.01	0.35	0.85	disease	0.84	disease	0.7	disease	0.79	disease	6	1	deleterious	0.18	neutral	1	deleterious	0.90	deleterious	-3.53	low_impact	0.09	medium_impact	1.89	medium_impact	0.20	0.8	21.05	43.58	0.35	N	0.95	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14775	14775	T	A	MI.8376	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	29	10	L	Q	cTa/cAa	-1.42	0	0	probably_damaging	0.99	neutral	0.42	neutral	4.36	deleterious	-3.34	deleterious	-2.91	high_impact	4.43	0.95	neutral	0.08	damaging	3.48	23.10	deleterious	0.02	0.35	0.81	disease	0.84	disease	0.64	disease	0.74	disease	5	0.99	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0.15	medium_impact	2.83	high_impact	0.14	0.8	21.05	43.58	0.43	N	0.92	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14775	14775	T	G	MI.8377	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	29	10	L	R	cTa/cGa	-1.42	0	0	probably_damaging	0.99	neutral	0.46	neutral	4.37	neutral	-2.99	deleterious	-2.98	high_impact	4.78	0.95	neutral	0.06	damaging	3.56	23.10	deleterious	0.01	0.35	0.8	disease	0.9	disease	0.75	disease	0.84	disease	7	0.99	deleterious	0.24	neutral	2	deleterious	0.90	deleterious	-2.59	low_impact	0.18	medium_impact	3.15	high_impact	0.02	0.8	21.05	43.58	0.73	P	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14777	14777	A	T	MI.8378	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	31	11	M	L	Ata/Tta	-1.88	0	0	benign	0	neutral	0.81	neutral	4.85	neutral	1.26	neutral	0.18	neutral_impact	-1.14	0.98	neutral	0.86	neutral	-1.37	0.00	neutral	0.16	0.45	0.16	neutral	0.15	neutral	0.21	neutral	0.26	neutral	5	0.18	neutral	0.91	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.56	medium_impact	-2.23	low_impact	0.31	0.8	18.16	13.84	0.4	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14777	14777	A	G	MI.8379	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	31	11	M	V	Ata/Gta	-1.88	0	0	benign	0	neutral	0.54	neutral	4.77	neutral	0.92	neutral	-0.72	low_impact	1.08	0.98	neutral	0.79	neutral	-0.36	0.48	neutral	0.19	0.45	0.21	neutral	0.49	neutral	0.29	neutral	0.49	neutral	0	0.46	neutral	0.77	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	0.26	medium_impact	-0.21	medium_impact	0.40	0.8	18.16	13.84	0.33	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8919	8919	A	T	MI.838	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	393	131	Q	H	caA/caT	5.68	1	0	probably_damaging	1	neutral	0.05	neutral	4.3	neutral	-1.33	deleterious	-3.38	medium_impact	2.04	0.81	neutral	0.16	damaging	3.58	23.20	deleterious	0.64	0.7	0.64	disease	0.52	disease	0.46	neutral	0.49	neutral	0	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.43	medium_impact	0.65	medium_impact	0.57	0.9	44.69	8.63	0.49	N	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14777	14777	A	C	MI.8380	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	31	11	M	L	Ata/Cta	-1.88	0	0	benign	0	neutral	0.81	neutral	4.85	neutral	1.26	neutral	0.18	neutral_impact	-1.14	0.98	neutral	0.86	neutral	-1.47	0.00	neutral	0.16	0.45	0.16	neutral	0.15	neutral	0.21	neutral	0.26	neutral	5	0.18	neutral	0.91	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.56	medium_impact	-2.23	low_impact	0.31	0.8	18.16	13.84	0.39	N	0.09	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14778	14778	T	A	MI.8381	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	32	11	M	K	aTa/aAa	-3.94	0	0	benign	0.04	neutral	1	neutral	4.64	neutral	-0.82	deleterious	-2.53	medium_impact	2.39	0.94	neutral	0.54	neutral	1.96	15.95	deleterious	0.02	0.35	0.32	neutral	0.74	disease	0.62	disease	0.74	disease	5	0.04	neutral	0.98	deleterious	-3	neutral	0.25	neutral	0.56	medium_impact	1.85	high_impact	0.98	medium_impact	0.24	0.8	18.16	13.84	0.2	N	0.71	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14778	14778	T	C	MI.8382	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	32	11	M	T	aTa/aCa	-3.94	0	0	benign	0.03	neutral	0.72	neutral	4.69	neutral	0.04	neutral	-1.97	low_impact	1.04	0.99	neutral	0.93	neutral	0.85	9.79	deleterious	0.06	0.35	0.3	neutral	0.53	disease	0.46	neutral	0.49	neutral	0	0.22	neutral	0.85	deleterious	-6	neutral	0.20	neutral	0.68	medium_impact	0.44	medium_impact	-0.25	medium_impact	0.19	0.8	18.16	13.84	0.32	N	0.49	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14779	14779	A	C	MI.8383	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	33	11	M	I	atA/atC	2.48	0.05	0	benign	0	neutral	0.44	neutral	4.74	neutral	0.54	neutral	-0.35	neutral_impact	-0.24	0.97	neutral	0.87	neutral	-0.64	0.10	neutral	0.18	0.45	0.19	neutral	0.3	neutral	0.21	neutral	0.44	neutral	1	0.55	neutral	0.72	deleterious	-6	neutral	0.15	neutral	2.07	high_impact	0.17	medium_impact	-1.41	low_impact	0.44	0.8	18.16	13.84	0.46	N	0.04	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14779	14779	A	T	MI.8384	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	33	11	M	I	atA/atT	2.48	0.05	0	benign	0	neutral	0.44	neutral	4.74	neutral	0.54	neutral	-0.35	neutral_impact	-0.24	0.97	neutral	0.87	neutral	-0.56	0.16	neutral	0.18	0.45	0.19	neutral	0.3	neutral	0.21	neutral	0.44	neutral	1	0.55	neutral	0.72	deleterious	-6	neutral	0.15	neutral	2.07	high_impact	0.17	medium_impact	-1.41	low_impact	0.44	0.8	18.16	13.84	0.46	N	0.04	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14780	14780	A	C	MI.8385	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	34	12	K	Q	Aaa/Caa	-1.65	0	0	probably_damaging	0.94	neutral	0.37	neutral	4.52	neutral	-1.79	neutral	-2.25	medium_impact	3.5	0.94	neutral	0.14	damaging	1.38	12.68	neutral	0.25	0.45	0.44	neutral	0.79	disease	0.47	neutral	0.62	disease	2	0.94	neutral	0.22	neutral	1	deleterious	0.75	deleterious	-1.85	low_impact	0.1	medium_impact	1.98	medium_impact	0.39	0.8	57.89	8.54	0.32	N	0.93	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14780	14780	A	G	MI.8386	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	34	12	K	E	Aaa/Gaa	-1.65	0	0	probably_damaging	0.94	neutral	0.41	neutral	4.56	neutral	-0.4	neutral	-2.25	high_impact	3.75	0.79	neutral	0.13	damaging	2.00	16.19	deleterious	0.13	0.4	0.36	neutral	0.82	disease	0.6	disease	0.69	disease	4	0.94	neutral	0.24	neutral	2	deleterious	0.78	deleterious	-1.85	low_impact	0.14	medium_impact	2.21	high_impact	0.48	0.8	57.89	8.54	0.27	N	0.95	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14781	14781	A	T	MI.8387	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	35	12	K	M	aAa/aTa	5.46	1	0	probably_damaging	0.99	neutral	0.26	neutral	4.45	deleterious	-4.22	deleterious	-3.43	high_impact	4.03	0.91	neutral	0.15	damaging	3.26	22.80	deleterious	0.06	0.35	0.74	disease	0.79	disease	0.49	neutral	0.65	disease	3	0.99	deleterious	0.14	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	-0.02	medium_impact	2.47	high_impact	0.18	0.8	57.89	8.54	0.54	N	0.67	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14781	14781	A	C	MI.8388	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	35	12	K	T	aAa/aCa	5.46	1	0	probably_damaging	0.98	neutral	0.47	neutral	4.51	neutral	-1.63	deleterious	-3.37	high_impact	3.85	0.91	neutral	0.14	damaging	1.70	14.40	neutral	0.04	0.35	0.46	neutral	0.8	disease	0.5	neutral	0.66	disease	3	0.98	neutral	0.25	neutral	2	deleterious	0.80	deleterious	-2.31	low_impact	0.19	medium_impact	2.3	high_impact	0.20	0.8	57.89	8.54	0.53	N	0.88	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14782	14782	A	T	MI.8389	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	36	12	K	N	aaA/aaT	6.61	1	0	probably_damaging	0.99	neutral	0.39	neutral	4.52	neutral	-0.72	deleterious	-2.65	medium_impact	2.56	0.91	neutral	0.14	damaging	1.91	15.64	deleterious	0.31	0.45	0.4	neutral	0.76	disease	0.49	neutral	0.56	disease	1	0.99	deleterious	0.2	neutral	1	deleterious	0.78	deleterious	-2.59	low_impact	0.12	medium_impact	1.13	medium_impact	0.47	0.8	57.89	8.54	0.52	N	0.84	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8920	8920	G	A	MI.839	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	394	132	G	S	Ggc/Agc	2.67	1	0	probably_damaging	1	neutral	0.07	neutral	3.52	neutral	-2.98	deleterious	-5.42	medium_impact	3.17	0.61	neutral	0.5	neutral	4.19	23.90	deleterious	0.41	0.65	0.83	disease	0.75	disease	0.61	disease	0.54	disease	1	1	deleterious	0.04	neutral	1	deleterious	0.82	deleterious	-3.6	low_impact	-0.34	medium_impact	1.62	medium_impact	0.79	0.9	48.23	8.73	0.41	N	0.98	disease_causing	1	0.20	rs28406348	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14782	14782	A	C	MI.8390	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	36	12	K	N	aaA/aaC	6.61	1	0	probably_damaging	0.99	neutral	0.39	neutral	4.52	neutral	-0.72	deleterious	-2.65	medium_impact	2.56	0.91	neutral	0.14	damaging	1.85	15.26	deleterious	0.31	0.45	0.4	neutral	0.76	disease	0.49	neutral	0.56	disease	1	0.99	deleterious	0.2	neutral	1	deleterious	0.78	deleterious	-2.59	low_impact	0.12	medium_impact	1.13	medium_impact	0.47	0.8	57.89	8.54	0.5	N	0.84	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14783	14783	T	G	MI.8391	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	37	13	L	V	Tta/Gta	6.84	1	0.71	probably_damaging	0.98	neutral	0.64	neutral	4.61	neutral	-0.67	neutral	0.31	low_impact	1.36	0.96	neutral	0.78	neutral	1.62	13.94	neutral	0.27	0.45	0.29	neutral	0.4	neutral	0.21	neutral	0.42	neutral	2	0.98	deleterious	0.33	neutral	-2	neutral	0.69	deleterious	-2.31	low_impact	0.36	medium_impact	0.04	medium_impact	0.71	0.85	22.37	58.02	0.5	N	0.25	polymorphism	1	0.01	rs193302982	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	14783	14783	T	A	MI.8392	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	37	13	L	M	Tta/Ata	6.84	1	0.71	probably_damaging	1	neutral	0.23	neutral	4.53	neutral	-1.63	neutral	-0.48	neutral_impact	0.19	0.94	neutral	0.91	neutral	2.24	17.76	deleterious	0.24	0.45	0.47	neutral	0.29	neutral	0.18	neutral	0.4	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.71	deleterious	-3.53	low_impact	-0.06	medium_impact	-1.02	low_impact	0.56	0.8	22.37	58.02	0.58	P	0.04	polymorphism	1	0.02	rs193302982	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	14784	14784	T	C	MI.8393	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	38	13	L	S	tTa/tCa	3.63	1	0	probably_damaging	0.99	neutral	0.54	neutral	4.48	neutral	-2.26	neutral	-2.36	medium_impact	2.14	0.94	neutral	0.64	neutral	3.35	22.90	deleterious	0.03	0.35	0.59	disease	0.54	disease	0.52	disease	0.56	disease	1	0.99	deleterious	0.28	neutral	1	deleterious	0.78	deleterious	-2.59	low_impact	0.26	medium_impact	0.75	medium_impact	0.17	0.8	22.37	58.02	0.4	N	0.63	polymorphism	1	0.08	rs527236163	Likely_pathogenic	Neoplasm_of_ovary	153591	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	14784	14784	T	G	MI.8394	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	38	13	L	W	tTa/tGa	3.63	1	0	probably_damaging	1	neutral	0.18	neutral	4.43	deleterious	-4.71	deleterious	-2.92	medium_impact	2.48	0.94	neutral	0.47	neutral	3.54	23.10	deleterious	0.04	0.35	0.85	disease	0.65	disease	0.54	disease	0.68	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	-0.14	medium_impact	1.06	medium_impact	0.20	0.8	22.37	58.02	0.53	N	0.76	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14785	14785	A	C	MI.8395	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	39	13	L	F	ttA/ttC	1.79	0.98	0	probably_damaging	0.99	neutral	0.75	neutral	4.49	neutral	-1.91	neutral	-1.3	low_impact	1.45	0.94	neutral	0.67	neutral	2.97	22.10	deleterious	0.19	0.45	0.57	disease	0.5	disease	0.51	disease	0.52	disease	0	0.99	deleterious	0.38	neutral	-2	neutral	0.77	deleterious	-2.59	low_impact	0.48	medium_impact	0.12	medium_impact	0.74	0.85	22.37	58.02	0.39	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14785	14785	A	T	MI.8396	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	39	13	L	F	ttA/ttT	1.79	0.98	0	probably_damaging	0.99	neutral	0.75	neutral	4.49	neutral	-1.91	neutral	-1.3	low_impact	1.45	0.94	neutral	0.67	neutral	3.08	22.50	deleterious	0.19	0.45	0.57	disease	0.5	disease	0.51	disease	0.52	disease	0	0.99	deleterious	0.38	neutral	-2	neutral	0.77	deleterious	-2.59	low_impact	0.48	medium_impact	0.12	medium_impact	0.74	0.85	22.37	58.02	0.4	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14786	14786	A	G	MI.8397	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	40	14	I	V	Att/Gtt	-1.65	0	0	benign	0	neutral	0.74	neutral	4.7	neutral	0.5	neutral	-0.1	neutral_impact	0.4	0.98	neutral	0.91	neutral	-0.52	0.20	neutral	0.49	0.55	0.16	neutral	0.16	neutral	0.24	neutral	0.27	neutral	5	0.26	neutral	0.87	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.47	medium_impact	-0.83	medium_impact	0.32	0.8	12.11	20.15	0.36	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14786	14786	A	T	MI.8398	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	40	14	I	F	Att/Ttt	-1.65	0	0	benign	0.12	neutral	0.65	neutral	4.59	neutral	-0.84	neutral	-1.85	medium_impact	2.06	0.95	neutral	0.15	damaging	1.64	14.08	neutral	0.09	0.35	0.71	disease	0.67	disease	0.33	neutral	0.5	neutral	0	0.24	neutral	0.77	deleterious	-3	neutral	0.45	deleterious	0.08	medium_impact	0.37	medium_impact	0.68	medium_impact	0.56	0.8	12.11	20.15	0.22	N	0.95	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14786	14786	A	C	MI.8399	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	40	14	I	L	Att/Ctt	-1.65	0	0	benign	0.01	neutral	1	neutral	4.7	neutral	0.4	neutral	-0.77	low_impact	1.14	0.97	neutral	0.69	neutral	0.60	8.18	deleterious	0.22	0.45	0.28	neutral	0.51	disease	0.24	neutral	0.46	neutral	1	0.01	neutral	1	deleterious	-6	neutral	0.17	neutral	1.13	medium_impact	1.85	high_impact	-0.16	medium_impact	0.62	0.8	12.11	20.15	0.29	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8563	8563	A	C	MI.84	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	37	13	T	P	Aca/Cca	-8.89	0	0.12	probably_damaging	1	deleterious	0.02	neutral	4.5	neutral	-2.58	deleterious	-3.81	medium_impact	2.1	0.73	neutral	0.33	neutral	3.31	22.90	deleterious	0.19	0.65	0.81	disease	0.9	disease	0.72	disease	0.82	disease	6	1	deleterious	0.01	neutral	5	deleterious	0.82	deleterious	-3.6	low_impact	-0.66	medium_impact	0.7	medium_impact	0.56	0.9	15.49	16.77	0.26	N	0.96	polymorphism	1	0.18	rs386829041	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8920	8920	G	C	MI.840	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	394	132	G	R	Ggc/Cgc	2.67	1	0	probably_damaging	1	deleterious	0	neutral	3.47	deleterious	-3.62	deleterious	-7.28	high_impact	4.03	0.55	damaging	0.31	neutral	3.97	23.60	deleterious	0.33	0.65	0.88	disease	0.88	disease	0.73	disease	0.68	disease	4	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.36	high_impact	0.87	0.9	48.23	8.73	0.43	N	0.98	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14787	14787	T	G	MI.8400	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	41	14	I	S	aTt/aGt	-0.04	0	0	benign	0.23	neutral	0.78	neutral	4.56	neutral	-1.21	neutral	-2.12	medium_impact	3.26	0.94	neutral	0.15	damaging	2.25	17.81	deleterious	0.02	0.35	0.77	disease	0.79	disease	0.55	disease	0.74	disease	5	0.14	neutral	0.78	deleterious	-3	neutral	0.47	deleterious	-0.24	medium_impact	0.52	medium_impact	1.77	medium_impact	0.23	0.8	12.11	20.15	0.2	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14787	14787	T	A	MI.8401	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	41	14	I	N	aTt/aAt	-0.04	0	0	possibly_damaging	0.57	neutral	0.67	neutral	4.53	neutral	-2.38	deleterious	-3.07	high_impact	4.24	0.93	neutral	0.16	damaging	2.51	19.56	deleterious	0.05	0.35	0.87	disease	0.8	disease	0.58	disease	0.78	disease	6	0.49	neutral	0.55	deleterious	1	deleterious	0.74	deleterious	-0.85	medium_impact	0.39	medium_impact	2.66	high_impact	0.23	0.8	12.11	20.15	0.28	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14787	14787	T	C	MI.8402	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	41	14	I	T	aTt/aCt	-0.04	0	0	benign	0.08	neutral	0.66	neutral	4.58	neutral	-0.9	neutral	-1.76	medium_impact	2.69	0.94	neutral	0.16	damaging	1.39	12.72	neutral	0.04	0.35	0.66	disease	0.61	disease	0.39	neutral	0.52	disease	0	0.25	neutral	0.79	deleterious	-3	neutral	0.33	neutral	0.26	medium_impact	0.38	medium_impact	1.25	medium_impact	0.30	0.8	12.11	20.15	0.21	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14788	14788	T	A	MI.8403	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	42	14	I	M	atT/atA	2.48	0.04	0	benign	0.23	neutral	0.29	neutral	4.58	neutral	-0.96	neutral	-1.1	low_impact	1.64	0.97	neutral	0.76	neutral	0.51	7.53	deleterious	0.21	0.45	0.59	disease	0.45	neutral	0.25	neutral	0.61	disease	2	0.65	neutral	0.53	deleterious	-6	neutral	0.32	neutral	-0.24	medium_impact	0.01	medium_impact	0.3	medium_impact	0.57	0.8	12.11	20.15	0.44	N	0.70	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14788	14788	T	G	MI.8404	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	42	14	I	M	atT/atG	2.48	0.04	0	benign	0.23	neutral	0.29	neutral	4.58	neutral	-0.96	neutral	-1.1	low_impact	1.64	0.97	neutral	0.76	neutral	0.27	5.37	deleterious	0.21	0.45	0.59	disease	0.45	neutral	0.25	neutral	0.61	disease	2	0.65	neutral	0.53	deleterious	-6	neutral	0.32	neutral	-0.24	medium_impact	0.01	medium_impact	0.3	medium_impact	0.57	0.8	12.11	20.15	0.44	N	0.70	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14789	14789	A	G	MI.8405	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	43	15	N	D	Aac/Gac	-6.24	0	0	benign	0.04	neutral	0.36	neutral	4.58	neutral	-1.04	deleterious	-3.05	high_impact	3.66	0.92	neutral	0.34	neutral	1.80	15.00	deleterious	0.46	0.55	0.52	disease	0.7	disease	0.62	disease	0.66	disease	3	0.61	neutral	0.66	deleterious	-2	neutral	0.29	neutral	0.56	medium_impact	0.09	medium_impact	2.13	high_impact	0.23	0.8	57.37	8.49	0.32	N	0.95	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14789	14789	A	C	MI.8406	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	43	15	N	H	Aac/Cac	-6.24	0	0	possibly_damaging	0.53	neutral	0.57	neutral	4.54	neutral	-1.89	deleterious	-3.05	high_impact	4.07	0.94	neutral	0.19	damaging	2.53	19.64	deleterious	0.21	0.45	0.72	disease	0.77	disease	0.68	disease	0.7	disease	4	0.48	neutral	0.52	deleterious	1	deleterious	0.69	deleterious	-0.78	medium_impact	0.29	medium_impact	2.5	high_impact	0.25	0.8	57.37	8.49	0.24	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14789	14789	A	T	MI.8407	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	43	15	N	Y	Aac/Tac	-6.24	0	0	possibly_damaging	0.65	neutral	1	neutral	4.55	neutral	-2.24	deleterious	-4.87	medium_impact	3.48	0.97	neutral	0.35	neutral	3.23	22.80	deleterious	0.05	0.35	0.45	neutral	0.82	disease	0.63	disease	0.69	disease	4	0.65	neutral	0.68	deleterious	0	NA	0.71	deleterious	-0.98	medium_impact	1.85	high_impact	1.97	medium_impact	0.24	0.8	57.37	8.49	0.23	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14790	14790	A	T	MI.8408	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	44	15	N	I	aAc/aTc	6.61	1	0	possibly_damaging	0.57	neutral	0.45	neutral	4.53	neutral	-2.39	deleterious	-5.49	high_impact	4.21	0.94	neutral	0.41	neutral	3.45	23.00	deleterious	0.05	0.35	0.74	disease	0.85	disease	0.62	disease	0.71	disease	4	0.58	neutral	0.44	neutral	1	deleterious	0.66	deleterious	-0.85	medium_impact	0.18	medium_impact	2.63	high_impact	0.17	0.8	57.37	8.49	0.63	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14790	14790	A	G	MI.8409	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	44	15	N	S	aAc/aGc	6.61	1	0	benign	0	neutral	0.59	neutral	4.62	neutral	-0.6	deleterious	-3.03	high_impact	3.56	0.94	neutral	0.44	neutral	1.03	10.85	neutral	0.39	0.5	0.52	disease	0.73	disease	0.48	neutral	0.49	neutral	0	0.41	neutral	0.8	deleterious	-2	neutral	0.27	neutral	2.07	high_impact	0.31	medium_impact	2.04	high_impact	0.32	0.8	57.37	8.49	0.52	N	0.86	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8920	8920	G	T	MI.841	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	394	132	G	C	Ggc/Tgc	2.67	1	0	probably_damaging	1	deleterious	0	neutral	3.43	deleterious	-6	deleterious	-8.21	high_impact	4.58	0.57	damaging	0.29	neutral	4.13	23.80	deleterious	0.24	0.65	0.98	disease	0.86	disease	0.69	disease	0.74	disease	5	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	2.83	high_impact	0.53	0.9	48.23	8.73	0.46	N	1.00	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14790	14790	A	C	MI.8410	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	44	15	N	T	aAc/aCc	6.61	1	0	benign	0.04	neutral	0.53	neutral	4.59	neutral	-0.91	deleterious	-3.64	medium_impact	3.41	0.94	neutral	0.4	neutral	1.39	12.76	neutral	0.16	0.45	0.59	disease	0.79	disease	0.64	disease	0.69	disease	4	0.42	neutral	0.75	deleterious	-3	neutral	0.34	neutral	0.56	medium_impact	0.25	medium_impact	1.9	medium_impact	0.26	0.8	57.37	8.49	0.51	N	0.94	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14791	14791	C	A	MI.8411	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	45	15	N	K	aaC/aaA	5.46	1	0	benign	0.15	neutral	0.53	neutral	4.66	neutral	-0.05	deleterious	-3.66	medium_impact	3.41	0.94	neutral	0.27	damaging	2.58	19.96	deleterious	0.22	0.45	0.38	neutral	0.81	disease	0.64	disease	0.69	disease	4	0.37	neutral	0.69	deleterious	-3	neutral	0.52	deleterious	-0.03	medium_impact	0.25	medium_impact	1.9	medium_impact	0.46	0.8	57.37	8.49	0.47	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14791	14791	C	G	MI.8412	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	45	15	N	K	aaC/aaG	5.46	1	0	benign	0.15	neutral	0.53	neutral	4.66	neutral	-0.05	deleterious	-3.66	medium_impact	3.41	0.94	neutral	0.27	damaging	2.14	17.09	deleterious	0.22	0.45	0.38	neutral	0.81	disease	0.64	disease	0.69	disease	4	0.37	neutral	0.69	deleterious	-3	neutral	0.52	deleterious	-0.03	medium_impact	0.25	medium_impact	1.9	medium_impact	0.46	0.8	57.37	8.49	0.47	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14792	14792	C	G	MI.8413	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	46	16	H	D	Cac/Gac	-2.11	0	0	benign	0.21	neutral	0.69	neutral	4.75	neutral	0.07	neutral	-0.02	neutral_impact	-0.25	0.96	neutral	0.76	neutral	-0.05	2.13	deleterious	0.05	0.35	0.24	neutral	0.19	neutral	0.42	neutral	0.36	neutral	3	0.2	neutral	0.74	deleterious	-6	neutral	0.25	neutral	-0.19	medium_impact	0.41	medium_impact	-1.42	low_impact	0.39	0.8	28.68	20.84	0.3	N	0.71	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14792	14792	C	T	MI.8414	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	46	16	H	Y	Cac/Tac	-2.11	0	0	benign	0.27	neutral	0.16	neutral	4.64	neutral	-1.77	neutral	-1.92	medium_impact	1.98	0.98	neutral	0.72	neutral	1.67	14.22	neutral	0.18	0.45	0.29	neutral	0.45	neutral	0.36	neutral	0.48	neutral	0	0.81	neutral	0.45	neutral	-3	neutral	0.36	neutral	-0.33	medium_impact	-0.17	medium_impact	0.6	medium_impact	0.28	0.8	28.68	20.84	0.51	N	0.72	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14792	14792	C	A	MI.8415	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	46	16	H	N	Cac/Aac	-2.11	0	0	benign	0.11	neutral	0.67	neutral	4.75	neutral	0.21	neutral	0.54	neutral_impact	-0.73	0.95	neutral	0.93	neutral	-0.62	0.11	neutral	0.3	0.45	0.14	neutral	0.14	neutral	0.25	neutral	0.23	neutral	5	0.22	neutral	0.78	deleterious	-6	neutral	0.17	neutral	0.12	medium_impact	0.39	medium_impact	-1.86	low_impact	0.31	0.8	28.68	20.84	0.3	N	0.06	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14793	14793	A	C	MI.8416	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	47	16	H	P	cAc/cCc	-0.96	0	0.07	benign	0.39	neutral	0.34	neutral	4.65	neutral	-1.61	neutral	-2.06	medium_impact	2.82	0.98	neutral	0.4	neutral	1.27	12.10	neutral	0.04	0.35	0.44	neutral	0.77	disease	0.7	disease	0.78	disease	6	0.6	neutral	0.48	deleterious	-3	neutral	0.56	deleterious	-0.55	medium_impact	0.07	medium_impact	1.37	medium_impact	0.18	0.8	28.68	20.84	0.36	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14793	14793	A	T	MI.8417	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	47	16	H	L	cAc/cTc	-0.96	0	0.07	benign	0.12	neutral	0.46	neutral	4.67	neutral	-0.95	deleterious	-3.02	medium_impact	2.67	0.95	neutral	0.52	neutral	1.90	15.58	deleterious	0.06	0.35	0.35	neutral	0.57	disease	0.48	neutral	0.49	neutral	0	0.46	neutral	0.67	deleterious	-3	neutral	0.28	neutral	0.08	medium_impact	0.18	medium_impact	1.23	medium_impact	0.17	0.8	28.68	20.84	0.34	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14793	14793	A	G	MI.8418	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	47	16	H	R	cAc/cGc	-0.96	0	0.07	benign	0	neutral	0.55	neutral	4.71	neutral	-0.02	neutral	-1.39	medium_impact	2.33	0.97	neutral	0.64	neutral	1.01	10.71	neutral	0.13	0.4	0.23	neutral	0.57	disease	0.55	disease	0.66	disease	3	0.44	neutral	0.78	deleterious	-3	neutral	0.17	neutral	2.07	high_impact	0.27	medium_impact	0.92	medium_impact	0.31	0.8	28.68	20.84	0.25	N	0.11	polymorphism	1	0.02	rs2853504	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14794	14794	C	A	MI.8419	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	48	16	H	Q	caC/caA	1.79	0	0	benign	0.12	neutral	0.6	neutral	4.72	neutral	0.09	neutral	-1.04	low_impact	1.92	0.96	neutral	0.67	neutral	0.76	9.19	deleterious	0.19	0.45	0.18	neutral	0.39	neutral	0.36	neutral	0.45	neutral	1	0.3	neutral	0.74	deleterious	-6	neutral	0.24	neutral	0.08	medium_impact	0.32	medium_impact	0.55	medium_impact	0.37	0.8	28.68	20.84	0.32	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8921	8921	G	A	MI.842	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	395	132	G	D	gGc/gAc	7.53	1	0	probably_damaging	1	deleterious	0.02	neutral	3.49	deleterious	-3.17	deleterious	-6.37	high_impact	4.03	0.65	neutral	0.37	neutral	3.87	23.50	deleterious	0.31	0.65	0.57	disease	0.86	disease	0.73	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.80	deleterious	-3.6	low_impact	-0.66	medium_impact	2.36	high_impact	0.39	0.9	48.23	8.73	0.5	P	1.00	disease_causing	1	0.22	rs2298008	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14794	14794	C	G	MI.8420	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	48	16	H	Q	caC/caG	1.79	0	0	benign	0.12	neutral	0.6	neutral	4.72	neutral	0.09	neutral	-1.04	low_impact	1.92	0.96	neutral	0.67	neutral	0.54	7.70	deleterious	0.19	0.45	0.18	neutral	0.39	neutral	0.36	neutral	0.45	neutral	1	0.3	neutral	0.74	deleterious	-6	neutral	0.24	neutral	0.08	medium_impact	0.32	medium_impact	0.55	medium_impact	0.37	0.8	28.68	20.84	0.31	N	0.60	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14795	14795	T	G	MI.8421	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	49	17	S	A	Tca/Gca	-1.88	0	0	possibly_damaging	0.76	neutral	0.55	neutral	4.66	neutral	-0.33	neutral	-0.45	neutral_impact	0.34	0.98	neutral	0.8	neutral	-0.07	2.01	deleterious	0.24	0.45	0.17	neutral	0.07	neutral	0.22	neutral	0.31	neutral	4	0.72	neutral	0.4	neutral	-3	neutral	0.40	neutral	-1.2	low_impact	0.27	medium_impact	-0.89	medium_impact	0.42	0.8	10	37.24	0.42	N	0.18	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14795	14795	T	A	MI.8422	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	49	17	S	T	Tca/Aca	-1.88	0	0	possibly_damaging	0.63	neutral	0.42	neutral	4.63	neutral	-0.38	neutral	-1.27	medium_impact	1.99	0.97	neutral	0.22	damaging	0.76	9.21	deleterious	0.19	0.45	0.33	neutral	0.46	neutral	0.27	neutral	0.47	neutral	1	0.65	neutral	0.4	neutral	0	NA	0.53	deleterious	-0.95	medium_impact	0.15	medium_impact	0.61	medium_impact	0.49	0.8	10	37.24	0.34	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14795	14795	T	C	MI.8423	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	49	17	S	P	Tca/Cca	-1.88	0	0	probably_damaging	0.93	neutral	0.23	neutral	4.56	neutral	-1.73	neutral	-2.38	medium_impact	3.23	0.95	neutral	0.09	damaging	1.98	16.06	deleterious	0.05	0.35	0.38	neutral	0.81	disease	0.71	disease	0.74	disease	5	0.95	neutral	0.15	neutral	1	deleterious	0.76	deleterious	-1.78	low_impact	-0.06	medium_impact	1.74	medium_impact	0.28	0.8	10	37.24	0.35	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14796	14796	C	T	MI.8424	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	50	17	S	L	tCa/tTa	0.41	0	0	probably_damaging	0.95	neutral	0.68	neutral	4.6	neutral	-1	deleterious	-2.72	medium_impact	2.98	0.95	neutral	0.11	damaging	2.69	20.80	deleterious	0.05	0.35	0.3	neutral	0.72	disease	0.57	disease	0.66	disease	3	0.95	neutral	0.37	neutral	1	deleterious	0.69	deleterious	-1.92	low_impact	0.4	medium_impact	1.51	medium_impact	0.37	0.8	10	37.24	0.21	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14796	14796	C	G	MI.8425	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	50	17	S	W	tCa/tGa	0.41	0	0	probably_damaging	0.99	neutral	0.19	neutral	4.53	deleterious	-4.53	deleterious	-3.59	high_impact	4.47	0.96	neutral	0.12	damaging	3.85	23.40	deleterious	0.06	0.35	0.77	disease	0.78	disease	0.64	disease	0.71	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	-0.12	medium_impact	2.87	high_impact	0.11	0.8	10	37.24	0.47	N	0.98	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14798	14798	T	C	MI.8426	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	52	18	F	L	Ttc/Ctc	-0.73	0	0.13	benign	0	neutral	0.66	neutral	4.8	neutral	0.58	neutral	-0.31	neutral_impact	-0.49	0.99	neutral	0.9	neutral	0.30	5.73	deleterious	0.17	0.45	0.15	neutral	0.18	neutral	0.41	neutral	0.24	neutral	5	0.34	neutral	0.83	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.38	medium_impact	-1.64	low_impact	0.72	0.85	17.89	26.96	0.34	N	0.09	polymorphism	1	0.01	rs28357681	.	.	.	.	glioblastoma	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14798	14798	T	G	MI.8427	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	52	18	F	V	Ttc/Gtc	-0.73	0	0.13	benign	0.02	neutral	0.51	neutral	4.67	neutral	-0.03	neutral	-1.58	low_impact	1.5	0.95	neutral	0.52	neutral	1.13	11.39	neutral	0.1	0.4	0.26	neutral	0.69	disease	0.54	disease	0.51	disease	0	0.47	neutral	0.75	deleterious	-6	neutral	0.17	neutral	0.85	medium_impact	0.23	medium_impact	0.17	medium_impact	0.37	0.8	17.89	26.96	0.27	N	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14798	14798	T	A	MI.8428	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	52	18	F	I	Ttc/Atc	-0.73	0	0.13	benign	0	neutral	0.4	neutral	4.65	neutral	-0.06	neutral	-0.96	medium_impact	2.63	0.94	neutral	0.46	neutral	2.43	19.00	deleterious	0.14	0.4	0.2	neutral	0.67	disease	0.52	disease	0.55	disease	1	0.59	neutral	0.7	deleterious	-3	neutral	0.17	neutral	2.07	high_impact	0.13	medium_impact	1.19	medium_impact	0.43	0.8	17.89	26.96	0.34	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14799	14799	T	G	MI.8429	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	53	18	F	C	tTc/tGc	-1.65	0	0	possibly_damaging	0.44	neutral	0.18	neutral	4.52	neutral	-2.91	deleterious	-2.6	high_impact	4.22	0.94	neutral	0.39	neutral	3.68	23.30	deleterious	0.03	0.35	0.64	disease	0.76	disease	0.71	disease	0.76	disease	5	0.79	neutral	0.37	neutral	1	deleterious	0.52	deleterious	-0.63	medium_impact	-0.14	medium_impact	2.64	high_impact	0.23	0.8	17.89	26.96	0.42	N	0.83	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8921	8921	G	C	MI.843	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	395	132	G	A	gGc/gCc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	3.49	neutral	-2.68	deleterious	-5.4	high_impact	3.68	0.66	neutral	0.46	neutral	3.10	22.50	deleterious	0.44	0.65	0.79	disease	0.62	disease	0.66	disease	0.58	disease	2	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.6	low_impact	-1.4	low_impact	2.06	high_impact	0.70	0.9	48.23	8.73	0.52	P	0.79	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14799	14799	T	A	MI.8430	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	53	18	F	Y	tTc/tAc	-1.65	0	0	benign	0.04	neutral	1	neutral	4.55	neutral	-1.64	neutral	-1.19	medium_impact	3.06	0.95	neutral	0.48	neutral	2.31	18.25	deleterious	0.14	0.4	0.56	disease	0.6	disease	0.7	disease	0.74	disease	5	0.04	neutral	0.98	deleterious	-3	neutral	0.24	neutral	0.56	medium_impact	1.85	high_impact	1.59	medium_impact	0.61	0.8	17.89	26.96	0.21	N	0.77	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14799	14799	T	C	MI.8431	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	53	18	F	S	tTc/tCc	-1.65	0	0	benign	0.08	neutral	0.42	neutral	4.56	neutral	-1.46	deleterious	-2.94	high_impact	3.87	0.93	neutral	0.48	neutral	2.37	18.66	deleterious	0.03	0.35	0.49	neutral	0.72	disease	0.67	disease	0.71	disease	4	0.53	neutral	0.67	deleterious	-2	neutral	0.31	neutral	0.26	medium_impact	0.15	medium_impact	2.32	high_impact	0.24	0.8	17.89	26.96	0.33	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14800	14800	C	A	MI.8432	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	54	18	F	L	ttC/ttA	7.3	0.95	0	benign	0	neutral	0.66	neutral	4.8	neutral	0.58	neutral	-0.31	neutral_impact	-0.49	0.99	neutral	0.9	neutral	0.92	10.20	neutral	0.17	0.45	0.15	neutral	0.18	neutral	0.41	neutral	0.24	neutral	5	0.34	neutral	0.83	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.38	medium_impact	-1.64	low_impact	0.72	0.85	17.89	26.96	0.53	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14800	14800	C	G	MI.8433	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	54	18	F	L	ttC/ttG	7.3	0.95	0	benign	0	neutral	0.66	neutral	4.8	neutral	0.58	neutral	-0.31	neutral_impact	-0.49	0.99	neutral	0.9	neutral	0.58	8.03	deleterious	0.17	0.45	0.15	neutral	0.18	neutral	0.41	neutral	0.24	neutral	5	0.34	neutral	0.83	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.38	medium_impact	-1.64	low_impact	0.72	0.85	17.89	26.96	0.53	N	0.09	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14801	14801	A	C	MI.8434	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	55	19	I	L	Atc/Ctc	-5.32	0	0	benign	0.01	neutral	0.88	neutral	4.69	neutral	0.1	neutral	-1.26	medium_impact	2.59	0.94	neutral	0.43	neutral	1.74	14.63	neutral	0.2	0.45	0.53	disease	0.57	disease	0.43	neutral	0.48	neutral	0	0.1	neutral	0.94	deleterious	-3	neutral	0.23	neutral	1.13	medium_impact	0.69	medium_impact	1.16	medium_impact	0.57	0.8	52.11	8.81	0.2	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14801	14801	A	G	MI.8435	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	55	19	I	V	Atc/Gtc	-5.32	0	0	benign	0	neutral	0.61	neutral	4.73	neutral	0.29	neutral	-0.3	low_impact	0.96	0.97	neutral	0.95	neutral	-0.30	0.66	neutral	0.36	0.5	0.28	neutral	0.09	neutral	0.25	neutral	0.28	neutral	4	0.39	neutral	0.81	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.33	medium_impact	-0.32	medium_impact	0.43	0.8	52.11	8.81	0.42	N	0.84	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14801	14801	A	T	MI.8436	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	55	19	I	F	Atc/Ttc	-5.32	0	0	benign	0.11	neutral	0.77	neutral	4.55	neutral	-1.47	deleterious	-2.53	medium_impact	3.4	0.93	neutral	0.46	neutral	1.76	14.77	neutral	0.05	0.35	0.83	disease	0.72	disease	0.52	disease	0.62	disease	2	0.12	neutral	0.83	deleterious	-3	neutral	0.52	deleterious	0.12	medium_impact	0.51	medium_impact	1.89	medium_impact	0.57	0.8	52.11	8.81	0.2	N	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14802	14802	T	A	MI.8437	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	56	19	I	N	aTc/aAc	2.48	0.98	0	possibly_damaging	0.62	neutral	0.38	neutral	4.51	neutral	-2.51	deleterious	-4.27	high_impact	3.98	0.92	neutral	0.44	neutral	2.68	20.70	deleterious	0.04	0.35	0.94	disease	0.77	disease	0.62	disease	0.82	disease	6	0.67	neutral	0.38	neutral	1	deleterious	0.72	deleterious	-0.93	medium_impact	0.11	medium_impact	2.42	high_impact	0.27	0.8	52.11	8.81	0.55	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14802	14802	T	G	MI.8438	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	56	19	I	S	aTc/aGc	2.48	0.98	0	benign	0.24	neutral	0.65	neutral	4.56	neutral	-1.1	deleterious	-3.63	medium_impact	3.32	0.94	neutral	0.42	neutral	2.42	18.94	deleterious	0.02	0.35	0.89	disease	0.8	disease	0.6	disease	0.77	disease	5	0.24	neutral	0.71	deleterious	-3	neutral	0.64	deleterious	-0.26	medium_impact	0.37	medium_impact	1.82	medium_impact	0.21	0.8	52.11	8.81	0.4	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14802	14802	T	C	MI.8439	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	56	19	I	T	aTc/aCc	2.48	0.98	0	benign	0.14	neutral	0.4	neutral	4.58	neutral	-0.95	deleterious	-2.83	medium_impact	2.72	0.96	neutral	0.46	neutral	1.48	13.21	neutral	0.03	0.35	0.8	disease	0.66	disease	0.52	disease	0.56	disease	1	0.53	neutral	0.63	deleterious	-3	neutral	0.50	deleterious	0	medium_impact	0.13	medium_impact	1.28	medium_impact	0.24	0.8	52.11	8.81	0.45	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8921	8921	G	T	MI.844	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	395	132	G	V	gGc/gTc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	3.46	deleterious	-3.27	deleterious	-8.18	high_impact	4.58	0.54	damaging	0.38	neutral	3.78	23.40	deleterious	0.26	0.65	0.92	disease	0.85	disease	0.68	disease	0.7	disease	4	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.83	high_impact	0.50	0.9	48.23	8.73	0.57	P	0.99	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14803	14803	C	A	MI.8440	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	57	19	I	M	atC/atA	7.3	1	0	benign	0.01	neutral	0.21	neutral	4.56	neutral	-1.14	neutral	-1.73	medium_impact	2.92	0.87	neutral	0.56	neutral	1.90	15.56	deleterious	0.11	0.4	0.79	disease	0.55	disease	0.43	neutral	0.56	disease	1	0.79	neutral	0.6	deleterious	-3	neutral	0.26	neutral	1.13	medium_impact	-0.09	medium_impact	1.46	medium_impact	0.58	0.8	52.11	8.81	0.62	P	0.82	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14803	14803	C	G	MI.8441	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	57	19	I	M	atC/atG	7.3	1	0	benign	0.01	neutral	0.21	neutral	4.56	neutral	-1.14	neutral	-1.73	medium_impact	2.92	0.87	neutral	0.56	neutral	1.43	12.93	neutral	0.11	0.4	0.79	disease	0.55	disease	0.43	neutral	0.56	disease	1	0.79	neutral	0.6	deleterious	-3	neutral	0.26	neutral	1.13	medium_impact	-0.09	medium_impact	1.46	medium_impact	0.58	0.8	52.11	8.81	0.62	P	0.82	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14804	14804	G	T	MI.8442	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	58	20	D	Y	Gac/Tac	-3.94	0	0	probably_damaging	1	neutral	1	neutral	4.5	neutral	-2.74	deleterious	-5.8	high_impact	4.22	0.81	neutral	0.44	neutral	3.67	23.30	deleterious	0.03	0.35	0.75	disease	0.9	disease	0.66	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.87	deleterious	-3.53	low_impact	1.85	high_impact	2.64	high_impact	0.16	0.8	57.63	8.6	0.29	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14804	14804	G	C	MI.8443	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	58	20	D	H	Gac/Cac	-3.94	0	0	probably_damaging	1	neutral	0.54	neutral	4.53	neutral	-1.99	deleterious	-4.5	high_impact	4.22	0.8	neutral	0.34	neutral	3.35	22.90	deleterious	0.04	0.35	0.66	disease	0.83	disease	0.66	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.26	medium_impact	2.64	high_impact	0.50	0.8	57.63	8.6	0.27	N	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14804	14804	G	A	MI.8444	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	58	20	D	N	Gac/Aac	-3.94	0	0	probably_damaging	0.99	neutral	0.33	neutral	4.56	neutral	-1.11	deleterious	-3.21	high_impact	3.53	0.64	neutral	0.45	neutral	2.44	19.05	deleterious	0.28	0.45	0.4	neutral	0.75	disease	0.53	disease	0.63	disease	3	0.99	deleterious	0.17	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.06	medium_impact	2.01	high_impact	0.85	0.9	57.63	8.6	0.41	N	0.99	polymorphism	1	0.02	.	.	.	.	.	.	COSM6716235	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14805	14805	A	C	MI.8445	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	59	20	D	A	gAc/gCc	8.9	1	0	probably_damaging	0.99	neutral	0.51	neutral	4.59	neutral	-0.7	deleterious	-5.14	high_impact	3.84	0.82	neutral	0.47	neutral	2.37	18.63	deleterious	0.04	0.35	0.37	neutral	0.75	disease	0.6	disease	0.67	disease	3	0.99	deleterious	0.26	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.23	medium_impact	2.29	high_impact	0.39	0.8	57.63	8.6	0.56	P	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14805	14805	A	T	MI.8446	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	59	20	D	V	gAc/gTc	8.9	1	0	probably_damaging	1	neutral	0.52	neutral	4.52	neutral	-1.93	deleterious	-5.8	high_impact	4.14	0.81	neutral	0.48	neutral	4.02	23.60	deleterious	0.02	0.35	0.61	disease	0.89	disease	0.62	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.24	medium_impact	2.57	high_impact	0.13	0.8	57.63	8.6	0.57	P	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14805	14805	A	G	MI.8447	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	59	20	D	G	gAc/gGc	8.9	1	0	probably_damaging	1	neutral	0.33	neutral	4.53	neutral	-1.47	deleterious	-4.5	high_impact	3.73	0.8	neutral	0.47	neutral	4.05	23.70	deleterious	0.04	0.35	0.59	disease	0.82	disease	0.62	disease	0.68	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.06	medium_impact	2.19	high_impact	0.31	0.8	57.63	8.6	0.59	P	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14806	14806	C	G	MI.8448	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	60	20	D	E	gaC/gaG	6.84	1	0	probably_damaging	0.95	neutral	0.28	neutral	4.65	neutral	0.05	deleterious	-2.58	medium_impact	3.12	0.84	neutral	0.46	neutral	1.90	15.59	deleterious	0.16	0.45	0.37	neutral	0.76	disease	0.51	disease	0.6	disease	2	0.96	neutral	0.17	neutral	1	deleterious	0.77	deleterious	-1.92	low_impact	0	medium_impact	1.64	medium_impact	0.51	0.8	57.63	8.6	0.52	P	1.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14806	14806	C	A	MI.8449	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	60	20	D	E	gaC/gaA	6.84	1	0	probably_damaging	0.95	neutral	0.28	neutral	4.65	neutral	0.05	deleterious	-2.58	medium_impact	3.12	0.84	neutral	0.46	neutral	2.24	17.80	deleterious	0.16	0.45	0.37	neutral	0.76	disease	0.51	disease	0.6	disease	2	0.96	neutral	0.17	neutral	1	deleterious	0.77	deleterious	-1.92	low_impact	0	medium_impact	1.64	medium_impact	0.51	0.8	57.63	8.6	0.54	P	1.00	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8923	8923	A	G	MI.845	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	397	133	T	A	Aca/Gca	-9.59	0	0	probably_damaging	0.99	neutral	0.28	neutral	4.28	neutral	-0.69	deleterious	-4.44	low_impact	1.6	0.93	neutral	0.62	neutral	3.48	23.10	deleterious	0.56	0.65	0.61	disease	0.36	neutral	0.75	disease	0.62	disease	2	0.99	deleterious	0.15	neutral	-2	neutral	0.69	deleterious	-2.65	low_impact	0.06	medium_impact	0.27	medium_impact	0.49	0.9	50	8.72	0.39	N	0.63	polymorphism	0.51	0.09	rs200329150	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14807	14807	C	A	MI.8450	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	61	21	L	I	Ctc/Atc	-1.42	0	0	probably_damaging	0.98	neutral	0.4	neutral	4.53	neutral	-1.86	neutral	-1.3	high_impact	3.96	0.87	neutral	0.06	damaging	2.47	19.27	deleterious	0.15	0.45	0.37	neutral	0.63	disease	0.53	disease	0.58	disease	1	0.99	deleterious	0.21	neutral	2	deleterious	0.75	deleterious	-2.31	low_impact	0.13	medium_impact	2.4	high_impact	0.56	0.8	57.89	8.86	0.28	N	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14807	14807	C	G	MI.8451	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	61	21	L	V	Ctc/Gtc	-1.42	0	0	probably_damaging	0.96	neutral	0.5	neutral	4.55	neutral	-1.64	neutral	-1.96	high_impact	4.64	0.81	neutral	0.08	damaging	1.47	13.17	neutral	0.14	0.4	0.33	neutral	0.57	disease	0.55	disease	0.62	disease	2	0.96	neutral	0.27	neutral	2	deleterious	0.72	deleterious	-2.02	low_impact	0.22	medium_impact	3.02	high_impact	0.49	0.8	57.89	8.86	0.43	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14807	14807	C	T	MI.8452	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	61	21	L	F	Ctc/Ttc	-1.42	0	0	probably_damaging	1	neutral	0.7	neutral	4.48	neutral	-2.37	deleterious	-2.61	high_impact	3.78	0.88	neutral	0.08	damaging	3.50	23.10	deleterious	0.06	0.35	0.36	neutral	0.69	disease	0.64	disease	0.67	disease	3	0.99	deleterious	0.35	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.42	medium_impact	2.24	high_impact	0.51	0.8	57.89	8.86	0.23	N	0.97	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14808	14808	T	G	MI.8453	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	62	21	L	R	cTc/cGc	-0.04	0	0	probably_damaging	1	neutral	0.35	neutral	4.45	neutral	-2.39	deleterious	-3.91	high_impact	5.2	0.83	neutral	0.03	damaging	3.92	23.50	deleterious	0.01	0.35	0.58	disease	0.84	disease	0.71	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.08	medium_impact	3.53	high_impact	0.13	0.8	57.89	8.86	0.66	P	0.99	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14808	14808	T	A	MI.8454	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	62	21	L	H	cTc/cAc	-0.04	0	0	probably_damaging	1	neutral	0.54	neutral	4.45	deleterious	-3.1	deleterious	-4.57	high_impact	4.22	0.88	neutral	0.06	damaging	3.94	23.50	deleterious	0.02	0.35	0.68	disease	0.78	disease	0.66	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.26	medium_impact	2.64	high_impact	0.21	0.8	57.89	8.86	0.3	N	0.95	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14808	14808	T	C	MI.8455	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	62	21	L	P	cTc/cCc	-0.04	0	0	probably_damaging	1	neutral	0.21	neutral	4.43	neutral	-2.99	deleterious	-4.57	high_impact	5.2	0.86	neutral	0.03	damaging	3.72	23.30	deleterious	0.01	0.35	0.69	disease	0.76	disease	0.58	disease	0.67	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.09	medium_impact	3.53	high_impact	0.26	0.8	57.89	8.86	0.6	P	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14810	14810	C	G	MI.8456	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	64	22	P	A	Ccc/Gcc	-20	0	0	probably_damaging	0.99	neutral	0.51	neutral	4.44	neutral	-1.05	deleterious	-5.26	high_impact	4.42	0.94	neutral	0.15	damaging	2.53	19.69	deleterious	0.07	0.35	0.56	disease	0.65	disease	0.64	disease	0.67	disease	3	0.99	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-2.59	low_impact	0.23	medium_impact	2.82	high_impact	0.73	0.85	57.63	8.82	0.38	N	0.82	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14810	14810	C	A	MI.8457	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	64	22	P	T	Ccc/Acc	-20	0	0	probably_damaging	1	neutral	0.39	neutral	4.42	neutral	-1.81	deleterious	-5.26	high_impact	5.32	0.92	neutral	0.11	damaging	3.40	23.00	deleterious	0.07	0.35	0.62	disease	0.8	disease	0.65	disease	0.69	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.12	medium_impact	3.64	high_impact	0.54	0.8	57.63	8.82	0.62	P	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14810	14810	C	T	MI.8458	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	64	22	P	S	Ccc/Tcc	-20	0	0	probably_damaging	1	neutral	0.42	neutral	4.42	neutral	-2.03	deleterious	-5.26	high_impact	4.76	0.93	neutral	0.1	damaging	3.60	23.20	deleterious	0.08	0.35	0.51	disease	0.79	disease	0.63	disease	0.69	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.15	medium_impact	3.13	high_impact	0.15	0.8	57.63	8.82	0.6	P	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14811	14811	C	A	MI.8459	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	65	22	P	H	cCc/cAc	7.07	1	0	probably_damaging	1	neutral	0.54	neutral	4.38	neutral	-2.95	deleterious	-5.93	high_impact	5.32	0.91	neutral	0.09	damaging	3.86	23.50	deleterious	0.04	0.35	0.77	disease	0.84	disease	0.68	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.26	medium_impact	3.64	high_impact	0.28	0.8	57.63	8.82	0.69	P	0.71	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8923	8923	A	T	MI.846	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	397	133	T	S	Aca/Tca	-9.59	0	0	probably_damaging	0.99	neutral	0.17	neutral	4.26	neutral	-1.77	deleterious	-3.52	medium_impact	2.43	0.92	neutral	0.61	neutral	3.28	22.80	deleterious	0.47	0.65	0.51	disease	0.42	neutral	0.66	disease	0.44	neutral	1	0.99	deleterious	0.09	neutral	1	deleterious	0.70	deleterious	-2.65	low_impact	-0.1	medium_impact	0.99	medium_impact	0.64	0.9	50	8.72	0.44	N	0.88	polymorphism	0.75	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14811	14811	C	T	MI.8460	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	65	22	P	L	cCc/cTc	7.07	1	0	probably_damaging	1	neutral	0.7	neutral	4.46	neutral	-0.56	deleterious	-6.58	high_impact	4.08	0.94	neutral	0.07	damaging	4.21	23.90	deleterious	0.05	0.35	0.65	disease	0.85	disease	0.61	disease	0.71	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.42	medium_impact	2.51	high_impact	0.75	0.85	57.63	8.82	0.47	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14811	14811	C	G	MI.8461	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	65	22	P	R	cCc/cGc	7.07	1	0	probably_damaging	1	neutral	0.35	neutral	4.4	neutral	-2.01	deleterious	-5.93	high_impact	4.08	0.96	neutral	0.08	damaging	3.40	23.00	deleterious	0.03	0.35	0.62	disease	0.86	disease	0.71	disease	0.76	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.08	medium_impact	2.51	high_impact	0.37	0.8	57.63	8.82	0.53	N	0.81	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14813	14813	A	C	MI.8462	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	67	23	T	P	Acc/Ccc	-10.14	0	0	possibly_damaging	0.48	neutral	0.4	neutral	4.55	neutral	-2.19	deleterious	-2.8	high_impact	4	0.93	neutral	0.38	neutral	3.50	23.10	deleterious	0.05	0.35	0.58	disease	0.82	disease	0.54	disease	0.72	disease	4	0.57	neutral	0.46	neutral	1	deleterious	0.47	deleterious	-0.7	medium_impact	0.13	medium_impact	2.44	high_impact	0.28	0.8	14.74	11.33	0.35	N	0.54	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14813	14813	A	T	MI.8463	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	67	23	T	S	Acc/Tcc	-10.14	0	0	benign	0.15	neutral	0.47	neutral	4.61	neutral	-0.66	neutral	-1.35	low_impact	1.71	0.96	neutral	0.77	neutral	0.82	9.60	deleterious	0.21	0.45	0.3	neutral	0.39	neutral	0.22	neutral	0.44	neutral	1	0.44	neutral	0.66	deleterious	-6	neutral	0.19	neutral	-0.03	medium_impact	0.19	medium_impact	0.36	medium_impact	0.54	0.8	14.74	11.33	0.42	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14813	14813	A	G	MI.8464	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	67	23	T	A	Acc/Gcc	-10.14	0	0	benign	0	neutral	0.58	neutral	4.71	neutral	-0.24	neutral	-1.31	neutral_impact	0.2	0.96	neutral	0.98	neutral	-0.26	0.82	neutral	0.18	0.45	0.18	neutral	0.09	neutral	0.2	neutral	0.28	neutral	4	0.41	neutral	0.79	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.3	medium_impact	-1.01	low_impact	0.27	0.8	14.74	11.33	0.46	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14814	14814	C	T	MI.8465	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	68	23	T	I	aCc/aTc	-1.42	0	0	benign	0.32	neutral	0.46	neutral	4.66	neutral	-0.62	deleterious	-2.82	medium_impact	3.35	0.93	neutral	0.54	neutral	3.47	23.00	deleterious	0.08	0.35	0.52	disease	0.79	disease	0.34	neutral	0.64	disease	3	0.45	neutral	0.57	deleterious	-3	neutral	0.36	neutral	-0.43	medium_impact	0.18	medium_impact	1.85	medium_impact	0.39	0.8	14.74	11.33	0.31	N	0.37	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14814	14814	C	G	MI.8466	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	68	23	T	S	aCc/aGc	-1.42	0	0	benign	0.15	neutral	0.47	neutral	4.61	neutral	-0.66	neutral	-1.35	low_impact	1.71	0.96	neutral	0.77	neutral	0.49	7.37	deleterious	0.21	0.45	0.3	neutral	0.39	neutral	0.22	neutral	0.44	neutral	1	0.44	neutral	0.66	deleterious	-6	neutral	0.19	neutral	-0.03	medium_impact	0.19	medium_impact	0.36	medium_impact	0.54	0.8	14.74	11.33	0.42	N	0.38	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14814	14814	C	A	MI.8467	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	68	23	T	N	aCc/aAc	-1.42	0	0	possibly_damaging	0.48	neutral	0.37	neutral	4.57	neutral	-2.25	neutral	-2.49	high_impact	4.2	0.87	neutral	0.58	neutral	1.91	15.66	deleterious	0.21	0.45	0.4	neutral	0.74	disease	0.6	disease	0.69	disease	4	0.6	neutral	0.45	neutral	1	deleterious	0.40	neutral	-0.7	medium_impact	0.1	medium_impact	2.62	high_impact	0.48	0.8	14.74	11.33	0.42	N	0.60	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14816	14816	C	A	MI.8468	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	70	24	P	T	Cca/Aca	-7.38	0	0	probably_damaging	1	neutral	0.45	neutral	4.21	deleterious	-4.14	deleterious	-5.29	high_impact	5.02	0.82	neutral	0.08	damaging	3.44	23.00	deleterious	0.07	0.35	0.94	disease	0.82	disease	0.73	disease	0.82	disease	6	1	deleterious	0.23	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.18	medium_impact	3.36	high_impact	0.52	0.8	59.21	8.75	0.66	P	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14816	14816	C	T	MI.8469	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	70	24	P	S	Cca/Tca	-7.38	0	0	probably_damaging	1	neutral	0.48	neutral	4.23	deleterious	-3.25	deleterious	-5.28	high_impact	4.04	0.84	neutral	0.07	damaging	3.63	23.20	deleterious	0.09	0.35	0.92	disease	0.79	disease	0.67	disease	0.8	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.2	medium_impact	2.48	high_impact	0.17	0.8	59.21	8.75	0.28	N	0.90	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8923	8923	A	C	MI.847	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	397	133	T	P	Aca/Cca	-9.59	0	0	probably_damaging	1	deleterious	0	neutral	4.19	neutral	-1.89	deleterious	-5.4	medium_impact	3.32	0.77	neutral	0.49	neutral	3.55	23.10	deleterious	0.22	0.65	0.87	disease	0.71	disease	0.76	disease	0.77	disease	5	1	deleterious	0	neutral	5	deleterious	0.79	deleterious	-3.6	low_impact	-1.4	low_impact	1.75	medium_impact	0.48	0.9	50	8.72	0.33	N	0.99	disease_causing	0.83	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14816	14816	C	G	MI.8470	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	70	24	P	A	Cca/Gca	-7.38	0	0	probably_damaging	0.99	neutral	0.57	neutral	4.24	deleterious	-3.87	deleterious	-5.29	high_impact	4.26	0.87	neutral	0.11	damaging	2.51	19.56	deleterious	0.08	0.35	0.91	disease	0.66	disease	0.73	disease	0.75	disease	5	0.99	deleterious	0.29	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.29	medium_impact	2.67	high_impact	0.61	0.8	59.21	8.75	0.32	N	0.84	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14817	14817	C	G	MI.8471	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	71	24	P	R	cCa/cGa	4.31	0.99	0	probably_damaging	1	neutral	0.34	neutral	4.2	deleterious	-4.34	deleterious	-5.97	high_impact	5.37	0.82	neutral	0.05	damaging	3.43	23.00	deleterious	0.04	0.35	0.96	disease	0.86	disease	0.77	disease	0.86	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.07	medium_impact	3.68	high_impact	0.33	0.8	59.21	8.75	0.71	P	0.80	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14817	14817	C	A	MI.8472	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	71	24	P	Q	cCa/cAa	4.31	0.99	0	probably_damaging	1	neutral	0.28	neutral	4.2	deleterious	-4.9	deleterious	-5.3	high_impact	5.37	0.85	neutral	0.05	damaging	3.92	23.50	deleterious	0.06	0.35	0.97	disease	0.85	disease	0.74	disease	0.82	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0	medium_impact	3.68	high_impact	0.37	0.8	59.21	8.75	0.71	P	0.86	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14817	14817	C	T	MI.8473	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	71	24	P	L	cCa/cTa	4.31	0.99	0	probably_damaging	1	neutral	0.7	neutral	4.21	deleterious	-4.62	deleterious	-6.64	high_impact	5.02	0.85	neutral	0.05	damaging	4.24	23.90	deleterious	0.05	0.35	0.96	disease	0.83	disease	0.72	disease	0.81	disease	6	1	deleterious	0.35	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.42	medium_impact	3.36	high_impact	0.74	0.85	59.21	8.75	0.64	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14819	14819	T	C	MI.8474	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	73	25	S	P	Tcc/Ccc	-5.32	0	0	benign	0.01	neutral	0.37	neutral	4.55	neutral	-2.1	neutral	-2.13	low_impact	1.86	0.91	neutral	0.74	neutral	2.34	18.43	deleterious	0.05	0.35	0.72	disease	0.76	disease	0.31	neutral	0.55	disease	1	0.62	neutral	0.68	deleterious	-6	neutral	0.27	neutral	1.13	medium_impact	0.1	medium_impact	0.5	medium_impact	0.18	0.8	35	7.83	0.31	N	0.30	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14819	14819	T	A	MI.8475	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	73	25	S	T	Tcc/Acc	-5.32	0	0	benign	0.14	neutral	0.43	neutral	4.59	neutral	-1.1	neutral	-1.17	medium_impact	2.24	0.9	neutral	0.48	neutral	1.77	14.83	neutral	0.18	0.45	0.49	neutral	0.65	disease	0.29	neutral	0.46	neutral	1	0.49	neutral	0.65	deleterious	-3	neutral	0.23	neutral	0	medium_impact	0.16	medium_impact	0.84	medium_impact	0.49	0.8	35	7.83	0.34	N	0.65	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14819	14819	T	G	MI.8476	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	73	25	S	A	Tcc/Gcc	-5.32	0	0	benign	0.13	neutral	0.51	neutral	4.65	neutral	-0.21	neutral	-1.32	medium_impact	2.22	0.9	neutral	0.53	neutral	0.72	8.99	deleterious	0.25	0.45	0.37	neutral	0.48	neutral	0.3	neutral	0.43	neutral	1	0.4	neutral	0.69	deleterious	-3	neutral	0.21	neutral	0.04	medium_impact	0.23	medium_impact	0.82	medium_impact	0.36	0.8	35	7.83	0.35	N	0.39	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14820	14820	C	G	MI.8477	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	74	25	S	C	tCc/tGc	0.41	0.02	0	probably_damaging	0.98	neutral	0.18	neutral	4.52	deleterious	-4.36	deleterious	-2.6	high_impact	3.52	0.84	neutral	0.34	neutral	3.35	22.90	deleterious	0.06	0.35	0.77	disease	0.83	disease	0.46	neutral	0.71	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	-0.14	medium_impact	2	high_impact	0.23	0.8	35	7.83	0.36	N	0.53	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14820	14820	C	A	MI.8478	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	74	25	S	Y	tCc/tAc	0.41	0.02	0	probably_damaging	0.94	neutral	1	neutral	4.54	neutral	-2.15	deleterious	-3.23	high_impact	3.96	0.84	neutral	0.39	neutral	3.98	23.60	deleterious	0.05	0.35	0.67	disease	0.87	disease	0.58	disease	0.71	disease	4	0.94	neutral	0.53	deleterious	2	deleterious	0.78	deleterious	-1.85	low_impact	1.85	high_impact	2.4	high_impact	0.20	0.8	35	7.83	0.25	N	0.99	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14820	14820	C	T	MI.8479	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	74	25	S	F	tCc/tTc	0.41	0.02	0	probably_damaging	0.99	neutral	0.74	neutral	4.53	deleterious	-3.35	deleterious	-3.25	high_impact	4.07	0.78	neutral	0.43	neutral	4.02	23.60	deleterious	0.04	0.35	0.61	disease	0.88	disease	0.58	disease	0.71	disease	4	0.99	deleterious	0.38	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.47	medium_impact	2.5	high_impact	0.09	0.8	35	7.83	0.26	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8924	8924	C	A	MI.848	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	398	133	T	K	aCa/aAa	8.69	1	0	probably_damaging	1	neutral	0.06	neutral	4.23	neutral	-2.71	deleterious	-5.37	high_impact	4.36	0.82	neutral	0.46	neutral	4.42	24.20	deleterious	0.25	0.65	0.71	disease	0.77	disease	0.81	disease	0.75	disease	5	1	deleterious	0.03	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	-0.38	medium_impact	2.64	high_impact	0.68	0.9	50	8.72	0.64	P	1.00	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14822	14822	A	C	MI.8480	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	76	26	N	H	Aac/Cac	-10.37	0	0	probably_damaging	1	neutral	0.54	neutral	4.34	neutral	-2.64	deleterious	-3.23	high_impact	4.93	0.85	neutral	0.15	damaging	2.81	21.40	deleterious	0.25	0.45	0.85	disease	0.74	disease	0.77	disease	0.81	disease	6	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.26	medium_impact	3.28	high_impact	0.15	0.8	54.74	10.28	0.7	P	0.75	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14822	14822	A	T	MI.8481	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	76	26	N	Y	Aac/Tac	-10.37	0	0	probably_damaging	1	neutral	1	neutral	4.32	deleterious	-3.34	deleterious	-5.15	high_impact	5.28	0.86	neutral	0.15	damaging	3.53	23.10	deleterious	0.06	0.35	0.89	disease	0.82	disease	0.78	disease	0.83	disease	7	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.53	low_impact	1.85	high_impact	3.6	high_impact	0.15	0.8	54.74	10.28	0.65	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14822	14822	A	G	MI.8482	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	76	26	N	D	Aac/Gac	-10.37	0	0	probably_damaging	0.98	neutral	0.21	neutral	4.36	neutral	-2.33	deleterious	-3.17	high_impact	4.58	0.84	neutral	0.13	damaging	2.02	16.34	deleterious	0.37	0.5	0.61	disease	0.65	disease	0.77	disease	0.75	disease	5	0.99	deleterious	0.12	neutral	2	deleterious	0.77	deleterious	-2.31	low_impact	-0.09	medium_impact	2.97	high_impact	0.25	0.8	54.74	10.28	0.53	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14823	14823	A	T	MI.8483	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	77	26	N	I	aAc/aTc	5.46	0.99	0	probably_damaging	1	neutral	0.41	neutral	4.31	deleterious	-3.79	deleterious	-5.77	high_impact	4.58	0.86	neutral	0.15	damaging	3.83	23.40	deleterious	0.08	0.35	0.86	disease	0.88	disease	0.74	disease	0.82	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.14	medium_impact	2.97	high_impact	0.11	0.8	54.74	10.28	0.64	P	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14823	14823	A	C	MI.8484	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	77	26	N	T	aAc/aCc	5.46	0.99	0	probably_damaging	0.99	neutral	0.39	neutral	4.36	neutral	-2.47	deleterious	-3.73	high_impact	4.08	0.86	neutral	0.18	damaging	1.71	14.44	neutral	0.2	0.45	0.66	disease	0.75	disease	0.7	disease	0.7	disease	4	0.99	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.12	medium_impact	2.51	high_impact	0.22	0.8	54.74	10.28	0.56	P	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14823	14823	A	G	MI.8485	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	77	26	N	S	aAc/aGc	5.46	0.99	0	probably_damaging	0.96	neutral	0.43	neutral	4.4	neutral	-1.82	deleterious	-2.93	medium_impact	2.17	0.95	neutral	0.82	neutral	0.06	3.21	deleterious	0.33	0.5	0.32	neutral	0.59	disease	0.58	disease	0.44	neutral	1	0.95	neutral	0.24	neutral	1	deleterious	0.73	deleterious	-2.02	low_impact	0.16	medium_impact	0.78	medium_impact	0.20	0.8	54.74	10.28	0.53	P	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14824	14824	C	A	MI.8486	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	78	26	N	K	aaC/aaA	3.17	0.98	0	probably_damaging	1	neutral	0.29	neutral	4.41	neutral	-1.78	deleterious	-3.79	high_impact	4.47	0.86	neutral	0.13	damaging	4.07	23.70	deleterious	0.24	0.45	0.69	disease	0.74	disease	0.73	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.01	medium_impact	2.87	high_impact	0.30	0.8	54.74	10.28	0.56	P	0.93	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14824	14824	C	G	MI.8487	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	78	26	N	K	aaC/aaG	3.17	0.98	0	probably_damaging	1	neutral	0.29	neutral	4.41	neutral	-1.78	deleterious	-3.79	high_impact	4.47	0.86	neutral	0.13	damaging	3.54	23.10	deleterious	0.24	0.45	0.69	disease	0.74	disease	0.73	disease	0.74	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.01	medium_impact	2.87	high_impact	0.30	0.8	54.74	10.28	0.56	P	0.93	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14825	14825	A	T	MI.8488	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	79	27	I	F	Atc/Ttc	-0.96	0.02	0	probably_damaging	0.99	neutral	0.72	neutral	4.51	neutral	-0.99	deleterious	-2.53	medium_impact	2.89	0.92	neutral	0.43	neutral	1.86	15.36	deleterious	0.05	0.35	0.72	disease	0.79	disease	0.65	disease	0.69	disease	4	0.99	deleterious	0.37	neutral	1	deleterious	0.80	deleterious	-2.59	low_impact	0.44	medium_impact	1.43	medium_impact	0.68	0.85	22.89	12.38	0.23	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14825	14825	A	C	MI.8489	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	79	27	I	L	Atc/Ctc	-0.96	0.02	0	probably_damaging	0.95	neutral	0.68	neutral	4.71	neutral	0.14	neutral	-0.97	low_impact	1.38	0.92	neutral	0.76	neutral	0.53	7.67	deleterious	0.23	0.45	0.27	neutral	0.5	disease	0.37	neutral	0.44	neutral	1	0.94	neutral	0.37	neutral	-2	neutral	0.59	deleterious	-1.92	low_impact	0.4	medium_impact	0.06	medium_impact	0.69	0.85	22.89	12.38	0.26	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8924	8924	C	T	MI.849	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	398	133	T	M	aCa/aTa	8.69	1	0	probably_damaging	1	deleterious	0	neutral	4.25	neutral	-1.91	deleterious	-5.38	high_impact	4.36	0.88	neutral	0.62	neutral	4.04	23.70	deleterious	0.43	0.65	0.8	disease	0.66	disease	0.81	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.74	deleterious	-3.6	low_impact	-1.4	low_impact	2.64	high_impact	0.64	0.9	50	8.72	0.6	P	0.98	disease_causing	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14825	14825	A	G	MI.8490	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	79	27	I	V	Atc/Gtc	-0.96	0.02	0	possibly_damaging	0.87	neutral	0.51	neutral	4.55	neutral	-0.75	neutral	-0.68	high_impact	4.53	0.91	neutral	0.5	neutral	0.91	10.14	neutral	0.5	0.6	0.38	neutral	0.41	neutral	0.66	disease	0.44	neutral	1	0.86	neutral	0.32	neutral	1	deleterious	0.57	deleterious	-1.5	low_impact	0.23	medium_impact	2.92	high_impact	0.58	0.8	22.89	12.38	0.48	N	0.52	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14826	14826	T	A	MI.8491	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	80	27	I	N	aTc/aAc	5.46	1	0	probably_damaging	1	neutral	0.4	neutral	4.41	deleterious	-3.37	deleterious	-4.58	high_impact	4.39	0.83	neutral	0.41	neutral	4.05	23.70	deleterious	0.04	0.35	0.93	disease	0.85	disease	0.75	disease	0.85	disease	7	1	deleterious	0.2	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.13	medium_impact	2.79	high_impact	0.34	0.8	22.89	12.38	0.65	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14826	14826	T	G	MI.8492	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	80	27	I	S	aTc/aGc	5.46	1	0	probably_damaging	1	neutral	0.48	neutral	4.46	neutral	-1.71	deleterious	-3.9	high_impact	4.38	0.84	neutral	0.39	neutral	3.85	23.40	deleterious	0.02	0.35	0.87	disease	0.83	disease	0.72	disease	0.79	disease	6	1	deleterious	0.24	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.2	medium_impact	2.78	high_impact	0.22	0.8	22.89	12.38	0.63	P	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14826	14826	T	C	MI.8493	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	80	27	I	T	aTc/aCc	5.46	1	0	probably_damaging	1	neutral	0.4	neutral	4.46	neutral	-1.8	deleterious	-3.22	high_impact	5.08	0.77	neutral	0.39	neutral	2.84	21.60	deleterious	0.03	0.35	0.78	disease	0.75	disease	0.74	disease	0.76	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.13	medium_impact	3.42	high_impact	0.25	0.8	22.89	12.38	0.76	P	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14827	14827	C	G	MI.8494	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	81	27	I	M	atC/atG	3.63	1	0	probably_damaging	1	neutral	0.23	neutral	4.45	neutral	-2.35	neutral	-1.74	high_impact	3.63	0.75	neutral	0.32	neutral	2.85	21.60	deleterious	0.08	0.35	0.68	disease	0.59	disease	0.62	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	-0.06	medium_impact	2.1	high_impact	0.71	0.85	22.89	12.38	0.49	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14827	14827	C	A	MI.8495	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	81	27	I	M	atC/atA	3.63	1	0	probably_damaging	1	neutral	0.23	neutral	4.45	neutral	-2.35	neutral	-1.74	high_impact	3.63	0.75	neutral	0.32	neutral	3.27	22.80	deleterious	0.08	0.35	0.68	disease	0.59	disease	0.62	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	-0.06	medium_impact	2.1	high_impact	0.71	0.85	22.89	12.38	0.49	N	0.79	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14828	14828	T	A	MI.8496	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	82	28	S	T	Tcc/Acc	-4.4	0	0	probably_damaging	0.93	neutral	0.39	neutral	4.52	neutral	-2.05	neutral	-2.01	medium_impact	2.85	0.98	neutral	0.45	neutral	1.71	14.46	neutral	0.14	0.4	0.6	disease	0.68	disease	0.63	disease	0.6	disease	2	0.93	neutral	0.23	neutral	1	deleterious	0.75	deleterious	-1.78	low_impact	0.12	medium_impact	1.39	medium_impact	0.56	0.8	57.89	9.06	0.33	N	0.70	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14828	14828	T	C	MI.8497	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	82	28	S	P	Tcc/Ccc	-4.4	0	0	probably_damaging	0.99	neutral	0.21	neutral	4.46	neutral	-2.86	deleterious	-3.4	high_impact	4.51	0.97	neutral	0.06	damaging	2.15	17.18	deleterious	0.04	0.35	0.7	disease	0.83	disease	0.7	disease	0.75	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	-0.09	medium_impact	2.9	high_impact	0.32	0.8	57.89	9.06	0.46	N	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14828	14828	T	G	MI.8498	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	82	28	S	A	Tcc/Gcc	-4.4	0	0	probably_damaging	0.96	neutral	0.5	neutral	4.53	neutral	-2.33	neutral	-2.05	high_impact	5.2	0.96	neutral	0.13	damaging	1.69	14.35	neutral	0.16	0.45	0.5	neutral	0.64	disease	0.7	disease	0.71	disease	4	0.96	neutral	0.27	neutral	2	deleterious	0.70	deleterious	-2.02	low_impact	0.22	medium_impact	3.53	high_impact	0.43	0.8	57.89	9.06	0.65	P	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14829	14829	C	T	MI.8499	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	83	28	S	F	tCc/tTc	7.3	1	0	probably_damaging	1	neutral	0.7	neutral	4.45	deleterious	-3.93	deleterious	-4.08	high_impact	4.86	0.95	neutral	0.08	damaging	3.93	23.50	deleterious	0.04	0.35	0.88	disease	0.88	disease	0.68	disease	0.79	disease	6	1	deleterious	0.35	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.42	medium_impact	3.22	high_impact	0.12	0.8	57.89	9.06	0.74	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8564	8564	C	A	MI.85	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	38	13	T	K	aCa/aAa	0.13	0	0	probably_damaging	1	neutral	0.06	neutral	4.58	neutral	-0.78	deleterious	-3.5	low_impact	1.29	0.8	neutral	0.6	neutral	4.16	23.80	deleterious	0.28	0.65	0.64	disease	0.87	disease	0.66	disease	0.6	disease	2	1	deleterious	0.03	neutral	-2	neutral	0.77	deleterious	-3.6	low_impact	-0.38	medium_impact	0.01	medium_impact	0.65	0.9	15.49	16.77	0.27	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8926	8926	C	T	MI.850	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	400	134	P	S	Cct/Tct	-9.59	0	0	probably_damaging	1	deleterious	0.04	neutral	3.52	deleterious	-3.11	deleterious	-7.16	medium_impact	3.19	0.67	neutral	0.13	damaging	3.95	23.60	deleterious	0.45	0.65	0.74	disease	0.73	disease	0.71	disease	0.71	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.80	deleterious	-3.6	low_impact	-0.49	medium_impact	1.64	medium_impact	0.34	0.9	49.56	8.76	0.27	N	0.82	disease_causing	0.94	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14829	14829	C	A	MI.8500	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	83	28	S	Y	tCc/tAc	7.3	1	0	probably_damaging	1	neutral	1	neutral	4.46	deleterious	-3.89	deleterious	-4.08	high_impact	4.51	0.95	neutral	0.08	damaging	3.81	23.40	deleterious	0.03	0.35	0.87	disease	0.86	disease	0.68	disease	0.79	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.53	low_impact	1.85	high_impact	2.9	high_impact	0.31	0.8	57.89	9.06	0.52	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14829	14829	C	G	MI.8501	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	83	28	S	C	tCc/tGc	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	4.44	deleterious	-5.45	deleterious	-3.41	high_impact	5.2	0.95	neutral	0.07	damaging	3.25	22.80	deleterious	0.04	0.35	0.86	disease	0.81	disease	0.7	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.14	medium_impact	3.53	high_impact	0.26	0.8	57.89	9.06	0.74	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14831	14831	G	T	MI.8502	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	85	29	A	S	Gca/Tca	-7.61	0	0.01	benign	0.03	neutral	0.47	neutral	4.67	neutral	-0.47	neutral	-0.77	neutral_impact	0.59	0.98	neutral	0.95	neutral	-0.79	0.04	neutral	0.15	0.45	0.18	neutral	0.25	neutral	0.24	neutral	0.43	neutral	1	0.5	neutral	0.72	deleterious	-6	neutral	0.11	neutral	0.68	medium_impact	0.19	medium_impact	-0.66	medium_impact	0.42	0.8	24.47	35.88	0.51	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14831	14831	G	A	MI.8503	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	85	29	A	T	Gca/Aca	-7.61	0	0.01	benign	0	neutral	0.39	neutral	4.65	neutral	-0.51	neutral	-0.89	low_impact	1.27	0.99	neutral	0.91	neutral	1.05	10.95	neutral	0.12	0.4	0.34	neutral	0.49	neutral	0.27	neutral	0.46	neutral	1	0.61	neutral	0.7	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.12	medium_impact	-0.04	medium_impact	0.65	0.8	24.47	35.88	0.46	N	0.04	disease_causing_automatic	0	0.02	rs199795644	Pathogenic	Leber's_optic_atrophy	76425	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	.	CPD	7.43	G14831A	LHON	+	-	Reported	1	P	P	P	neutral
chrM	14831	14831	G	C	MI.8504	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	85	29	A	P	Gca/Cca	-7.61	0	0.01	benign	0.08	neutral	0.21	neutral	4.6	neutral	-2.47	neutral	-2.11	high_impact	3.65	0.98	neutral	0.36	neutral	3.39	23.00	deleterious	0.04	0.35	0.6	disease	0.85	disease	0.59	disease	0.74	disease	5	0.77	neutral	0.57	deleterious	-2	neutral	0.29	neutral	0.26	medium_impact	-0.09	medium_impact	2.12	high_impact	0.43	0.8	24.47	35.88	0.39	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14832	14832	C	T	MI.8505	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	86	29	A	V	gCa/gTa	-1.65	0	0	benign	0.01	neutral	0.51	neutral	4.71	neutral	0.11	neutral	-0.9	low_impact	1.84	0.95	neutral	0.65	neutral	1.36	12.56	neutral	0.09	0.35	0.29	neutral	0.39	neutral	0.35	neutral	0.44	neutral	1	0.48	neutral	0.75	deleterious	-6	neutral	0.11	neutral	1.13	medium_impact	0.23	medium_impact	0.48	medium_impact	0.62	0.8	24.47	35.88	0.35	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14832	14832	C	A	MI.8506	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	86	29	A	E	gCa/gAa	-1.65	0	0	benign	0.09	neutral	0.27	neutral	4.62	neutral	-0.73	neutral	-1.97	high_impact	4.34	0.93	neutral	0.48	neutral	4.04	23.70	deleterious	0.03	0.35	0.43	neutral	0.8	disease	0.6	disease	0.73	disease	5	0.7	neutral	0.59	deleterious	-2	neutral	0.23	neutral	0.21	medium_impact	-0.01	medium_impact	2.75	high_impact	0.30	0.8	24.47	35.88	0.42	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14832	14832	C	G	MI.8507	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	86	29	A	G	gCa/gGa	-1.65	0	0	benign	0.01	neutral	0.35	neutral	4.6	neutral	-1.54	neutral	-1.93	medium_impact	3.1	0.97	neutral	0.81	neutral	0.85	9.80	deleterious	0.12	0.4	0.51	disease	0.48	neutral	0.41	neutral	0.43	neutral	1	0.64	neutral	0.67	deleterious	-3	neutral	0.14	neutral	1.13	medium_impact	0.08	medium_impact	1.62	medium_impact	0.57	0.8	24.47	35.88	0.39	N	0.32	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14834	14834	T	G	MI.8508	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	88	30	W	G	Tga/Gga	-7.16	0	0	probably_damaging	0.99	neutral	0.39	neutral	4.46	deleterious	-3.02	deleterious	-7.39	high_impact	4.5	0.75	neutral	0.13	damaging	2.13	17.08	deleterious	0.04	0.35	0.72	disease	0.83	disease	0.76	disease	0.78	disease	6	0.99	deleterious	0.2	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.12	medium_impact	2.89	high_impact	0.15	0.8	54.74	8.72	0.43	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14834	14834	T	C	MI.8509	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	88	30	W	R	Tga/Cga	-7.16	0	0	probably_damaging	1	neutral	0.34	neutral	4.47	neutral	-2.92	deleterious	-7.79	high_impact	4.15	0.65	neutral	0.06	damaging	3.15	22.60	deleterious	0.02	0.35	0.69	disease	0.91	disease	0.81	disease	0.83	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.07	medium_impact	2.57	high_impact	0.15	0.8	54.74	8.72	0.42	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8926	8926	C	G	MI.851	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	400	134	P	A	Cct/Gct	-9.59	0	0	probably_damaging	1	deleterious	0	neutral	3.48	neutral	-2.97	deleterious	-7.16	high_impact	4.06	0.69	neutral	0.15	damaging	3.10	22.50	deleterious	0.3	0.65	0.74	disease	0.56	disease	0.72	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.6	low_impact	-1.4	low_impact	2.38	high_impact	0.76	0.9	49.56	8.76	0.31	N	0.79	disease_causing	0.9	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14835	14835	G	C	MI.8510	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	89	30	W	S	tGa/tCa	5.69	1	0	probably_damaging	1	neutral	0.51	neutral	4.49	neutral	-1.94	deleterious	-7.71	high_impact	3.64	0.74	neutral	0.1	damaging	3.43	23.00	deleterious	0.03	0.35	0.43	neutral	0.91	disease	0.75	disease	0.79	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.23	medium_impact	2.11	high_impact	0.15	0.8	54.74	8.72	0.49	N	0.99	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14835	14835	G	T	MI.8511	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	89	30	W	L	tGa/tTa	5.69	1	0	probably_damaging	0.99	neutral	0.71	neutral	4.68	neutral	0.07	deleterious	-6.73	medium_impact	2.42	0.75	neutral	0.08	damaging	2.39	18.73	deleterious	0.06	0.35	0.2	neutral	0.79	disease	0.62	disease	0.51	disease	0	0.99	deleterious	0.36	neutral	1	deleterious	0.73	deleterious	-2.59	low_impact	0.43	medium_impact	1	medium_impact	0.14	0.8	54.74	8.72	0.36	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14836	14836	A	T	MI.8512	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	90	30	W	C	tgA/tgT	5	1	0	probably_damaging	1	neutral	0.19	neutral	4.45	deleterious	-3.65	deleterious	-7.12	high_impact	5.2	0.77	neutral	0.05	damaging	3.83	23.40	deleterious	0.03	0.35	0.76	disease	0.92	disease	0.76	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.12	medium_impact	3.53	high_impact	0.21	0.8	54.74	8.72	0.65	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14836	14836	A	C	MI.8513	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	90	30	W	C	tgA/tgC	5	1	0	probably_damaging	1	neutral	0.19	neutral	4.45	deleterious	-3.65	deleterious	-7.12	high_impact	5.2	0.77	neutral	0.05	damaging	3.85	23.40	deleterious	0.03	0.35	0.76	disease	0.92	disease	0.76	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.12	medium_impact	3.53	high_impact	0.21	0.8	54.74	8.72	0.64	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14837	14837	T	G	MI.8514	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	91	31	W	G	Tga/Gga	4.54	1	0	probably_damaging	1	neutral	0.42	neutral	3.9	deleterious	-5.72	deleterious	-9.03	high_impact	5.34	0.82	neutral	0.1	damaging	3.51	23.10	deleterious	0.02	0.35	0.93	disease	0.85	disease	0.8	disease	0.86	disease	7	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.15	medium_impact	3.66	high_impact	0.10	0.8	57.37	8.91	0.68	P	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14837	14837	T	C	MI.8515	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	91	31	W	R	Tga/Cga	4.54	1	0	probably_damaging	1	neutral	0.33	neutral	3.9	deleterious	-5.46	deleterious	-9.69	high_impact	5	0.77	neutral	0.06	damaging	3.36	22.90	deleterious	0.01	0.35	0.96	disease	0.91	disease	0.83	disease	0.85	disease	7	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.06	medium_impact	3.35	high_impact	0.16	0.8	57.37	8.91	0.63	P	0.99	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14838	14838	G	T	MI.8516	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	92	31	W	L	tGa/tTa	4.54	1	0	probably_damaging	1	neutral	0.9	neutral	3.94	deleterious	-3.5	deleterious	-9.03	high_impact	4.3	0.85	neutral	0.07	damaging	3.86	23.50	deleterious	0.02	0.35	0.92	disease	0.87	disease	0.79	disease	0.87	disease	7	1	deleterious	0.45	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.74	medium_impact	2.71	high_impact	0.13	0.8	57.37	8.91	0.54	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14838	14838	G	C	MI.8517	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	92	31	W	S	tGa/tCa	4.54	1	0	probably_damaging	1	neutral	0.55	neutral	3.91	deleterious	-4.88	deleterious	-9.69	high_impact	4.3	0.85	neutral	0.09	damaging	3.71	23.30	deleterious	0.02	0.35	0.96	disease	0.93	disease	0.79	disease	0.85	disease	7	1	deleterious	0.28	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.27	medium_impact	2.71	high_impact	0.10	0.8	57.37	8.91	0.53	N	0.99	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14839	14839	A	T	MI.8518	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	93	31	W	C	tgA/tgT	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	3.89	deleterious	-6.57	deleterious	-9.03	high_impact	5.34	0.82	neutral	0.05	damaging	3.91	23.50	deleterious	0.02	0.35	0.98	disease	0.93	disease	0.8	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.12	medium_impact	3.66	high_impact	0.17	0.8	57.37	8.91	0.64	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14839	14839	A	C	MI.8519	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	93	31	W	C	tgA/tgC	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	3.89	deleterious	-6.57	deleterious	-9.03	high_impact	5.34	0.82	neutral	0.05	damaging	3.78	23.40	deleterious	0.02	0.35	0.98	disease	0.93	disease	0.8	disease	0.85	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.12	medium_impact	3.66	high_impact	0.17	0.8	57.37	8.91	0.63	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8926	8926	C	A	MI.852	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	400	134	P	T	Cct/Act	-9.59	0	0	probably_damaging	1	deleterious	0.03	neutral	3.48	deleterious	-3.55	deleterious	-7.16	high_impact	4.61	0.69	neutral	0.11	damaging	3.77	23.40	deleterious	0.3	0.65	0.78	disease	0.74	disease	0.71	disease	0.71	disease	4	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-0.56	medium_impact	2.85	high_impact	0.74	0.9	49.56	8.76	0.41	N	0.93	disease_causing	0.93	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14840	14840	A	T	MI.8520	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	94	32	N	Y	Aac/Tac	0.87	0.98	0	probably_damaging	1	neutral	1	neutral	4.53	neutral	-1.81	deleterious	-5.58	high_impact	3.77	0.94	neutral	0.34	neutral	3.54	23.10	deleterious	0.05	0.35	0.94	disease	0.87	disease	0.73	disease	0.82	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.87	deleterious	-3.53	low_impact	1.85	high_impact	2.23	high_impact	0.27	0.8	57.11	8.6	0.38	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14840	14840	A	C	MI.8521	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	94	32	N	H	Aac/Cac	0.87	0.98	0	probably_damaging	1	neutral	0.54	neutral	4.5	neutral	-2.91	deleterious	-3.49	high_impact	4.96	0.94	neutral	0.23	damaging	2.95	22.10	deleterious	0.13	0.4	0.91	disease	0.79	disease	0.78	disease	0.84	disease	7	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.26	medium_impact	3.31	high_impact	0.29	0.8	57.11	8.6	0.68	P	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14840	14840	A	G	MI.8522	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	94	32	N	D	Aac/Gac	0.87	0.98	0	probably_damaging	0.99	neutral	0.2	neutral	4.5	neutral	-2.56	deleterious	-3.48	high_impact	4.62	0.92	neutral	0.38	neutral	3.34	22.90	deleterious	0.26	0.45	0.71	disease	0.73	disease	0.78	disease	0.76	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	-0.1	medium_impact	3	high_impact	0.42	0.8	57.11	8.6	0.66	P	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14841	14841	A	G	MI.8523	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	95	32	N	S	aAc/aGc	6.84	1	0	probably_damaging	0.98	neutral	0.46	neutral	4.55	neutral	-1.59	deleterious	-3.48	high_impact	4.03	0.93	neutral	0.45	neutral	1.05	10.97	neutral	0.23	0.45	0.73	disease	0.77	disease	0.71	disease	0.73	disease	5	0.98	neutral	0.24	neutral	2	deleterious	0.84	deleterious	-2.31	low_impact	0.18	medium_impact	2.47	high_impact	0.33	0.8	57.11	8.6	0.64	P	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	A14841G	LHON helper mut.	-	+	Reported	1	.	P	P	damaging
chrM	14841	14841	A	T	MI.8524	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	95	32	N	I	aAc/aTc	6.84	1	0	probably_damaging	1	neutral	0.41	neutral	4.58	neutral	-1.69	deleterious	-6.27	high_impact	4.21	0.95	neutral	0.44	neutral	3.54	23.10	deleterious	0.05	0.35	0.93	disease	0.9	disease	0.72	disease	0.82	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.14	medium_impact	2.63	high_impact	0.14	0.8	57.11	8.6	0.65	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14841	14841	A	C	MI.8525	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	95	32	N	T	aAc/aCc	6.84	1	0	probably_damaging	1	neutral	0.4	neutral	4.59	neutral	-1.68	deleterious	-4.18	high_impact	3.81	0.95	neutral	0.42	neutral	2.82	21.50	deleterious	0.12	0.4	0.79	disease	0.8	disease	0.73	disease	0.76	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.13	medium_impact	2.27	high_impact	0.36	0.8	57.11	8.6	0.63	P	0.94	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14842	14842	C	A	MI.8526	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	96	32	N	K	aaC/aaA	8.44	1	0	probably_damaging	1	neutral	0.29	neutral	4.52	neutral	-2.1	deleterious	-4.18	high_impact	4.5	0.95	neutral	0.29	neutral	4.14	23.80	deleterious	0.13	0.4	0.81	disease	0.82	disease	0.78	disease	0.8	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.01	medium_impact	2.89	high_impact	0.46	0.8	57.11	8.6	0.68	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14842	14842	C	G	MI.8527	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	96	32	N	K	aaC/aaG	8.44	1	0	probably_damaging	1	neutral	0.29	neutral	4.52	neutral	-2.1	deleterious	-4.18	high_impact	4.5	0.95	neutral	0.29	neutral	3.72	23.30	deleterious	0.13	0.4	0.81	disease	0.82	disease	0.78	disease	0.8	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.01	medium_impact	2.89	high_impact	0.46	0.8	57.11	8.6	0.68	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14843	14843	T	A	MI.8528	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	97	33	F	I	Ttc/Atc	-1.42	0.01	0	benign	0.08	neutral	0.4	neutral	4.41	neutral	-1.88	deleterious	-4.22	high_impact	4.33	0.94	neutral	0.11	damaging	2.80	21.40	deleterious	0.1	0.4	0.58	disease	0.86	disease	0.66	disease	0.73	disease	5	0.55	neutral	0.66	deleterious	-2	neutral	0.46	deleterious	0.26	medium_impact	0.13	medium_impact	2.74	high_impact	0.55	0.8	53.68	7.81	0.36	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14843	14843	T	G	MI.8529	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	97	33	F	V	Ttc/Gtc	-1.42	0.01	0	benign	0.24	neutral	0.5	neutral	4.44	neutral	-1.57	deleterious	-4.94	high_impact	4.57	0.95	neutral	0.11	damaging	3.66	23.20	deleterious	0.07	0.35	0.54	disease	0.85	disease	0.71	disease	0.76	disease	5	0.4	neutral	0.63	deleterious	-2	neutral	0.43	deleterious	-0.26	medium_impact	0.22	medium_impact	2.96	high_impact	0.39	0.8	53.68	7.81	0.4	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8927	8927	C	G	MI.853	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	401	134	P	R	cCt/cGt	3.6	0.99	0	probably_damaging	1	deleterious	0	neutral	3.47	deleterious	-3.61	deleterious	-8.09	high_impact	4.61	0.61	neutral	0.1	damaging	3.59	23.20	deleterious	0.25	0.65	0.78	disease	0.86	disease	0.78	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.85	high_impact	0.70	0.9	49.56	8.76	0.57	P	0.65	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14843	14843	T	C	MI.8530	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	97	33	F	L	Ttc/Ctc	-1.42	0.01	0	benign	0	neutral	0.65	neutral	4.55	neutral	0.02	deleterious	-4.19	medium_impact	2.93	0.97	neutral	0.3	neutral	2.17	17.30	deleterious	0.12	0.4	0.49	neutral	0.79	disease	0.57	disease	0.5	neutral	0	0.34	neutral	0.83	deleterious	-3	neutral	0.23	neutral	2.07	high_impact	0.37	medium_impact	1.47	medium_impact	0.69	0.85	53.68	7.81	0.23	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14844	14844	T	A	MI.8531	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	98	33	F	Y	tTc/tAc	7.3	1	0	benign	0.27	neutral	1	neutral	4.36	deleterious	-3	neutral	-2.09	medium_impact	3.42	0.95	neutral	0.11	damaging	2.30	18.18	deleterious	0.13	0.4	0.32	neutral	0.79	disease	0.65	disease	0.52	disease	0	0.27	neutral	0.87	deleterious	-3	neutral	0.52	deleterious	-0.33	medium_impact	1.85	high_impact	1.91	medium_impact	0.60	0.8	53.68	7.81	0.46	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14844	14844	T	C	MI.8532	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	98	33	F	S	tTc/tCc	7.3	1	0	possibly_damaging	0.7	neutral	0.4	neutral	4.36	neutral	-2.97	deleterious	-5.69	high_impact	4.57	0.93	neutral	0.08	damaging	3.75	23.30	deleterious	0.03	0.35	0.69	disease	0.86	disease	0.68	disease	0.73	disease	5	0.72	neutral	0.35	neutral	1	deleterious	0.73	deleterious	-1.07	low_impact	0.13	medium_impact	2.96	high_impact	0.26	0.8	53.68	7.81	0.6	P	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14844	14844	T	G	MI.8533	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	98	33	F	C	tTc/tGc	7.3	1	0	probably_damaging	0.92	neutral	0.18	neutral	4.33	deleterious	-4.32	deleterious	-5.68	high_impact	5.03	0.96	neutral	0.09	damaging	3.90	23.50	deleterious	0.04	0.35	0.85	disease	0.89	disease	0.68	disease	0.77	disease	5	0.95	neutral	0.13	neutral	2	deleterious	0.79	deleterious	-1.72	low_impact	-0.14	medium_impact	3.37	high_impact	0.23	0.8	53.68	7.81	0.69	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14845	14845	C	G	MI.8534	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	99	33	F	L	ttC/ttG	7.3	1	0	benign	0	neutral	0.65	neutral	4.55	neutral	0.02	deleterious	-4.19	medium_impact	2.93	0.97	neutral	0.3	neutral	2.38	18.66	deleterious	0.12	0.4	0.49	neutral	0.79	disease	0.57	disease	0.5	neutral	0	0.34	neutral	0.83	deleterious	-3	neutral	0.23	neutral	2.07	high_impact	0.37	medium_impact	1.47	medium_impact	0.69	0.85	53.68	7.81	0.5	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14845	14845	C	A	MI.8535	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	99	33	F	L	ttC/ttA	7.3	1	0	benign	0	neutral	0.65	neutral	4.55	neutral	0.02	deleterious	-4.19	medium_impact	2.93	0.97	neutral	0.3	neutral	2.65	20.50	deleterious	0.12	0.4	0.49	neutral	0.79	disease	0.57	disease	0.5	neutral	0	0.34	neutral	0.83	deleterious	-3	neutral	0.23	neutral	2.07	high_impact	0.37	medium_impact	1.47	medium_impact	0.69	0.85	53.68	7.81	0.5	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14846	14846	G	A	MI.8536	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	100	34	G	S	Ggc/Agc	-2.57	0	0	probably_damaging	1	neutral	0.4	neutral	2.9	deleterious	-7.32	deleterious	-4.44	high_impact	4.8	0.82	neutral	0.05	damaging	3.96	23.60	deleterious	0.05	0.35	0.9	disease	0.89	disease	0.72	disease	0.81	disease	6	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.13	medium_impact	3.17	high_impact	0.28	0.8	57.63	8.53	0.67	P	1.00	disease_causing_automatic	0	0.19	rs207459998	Pathogenic	Exercise_intolerance	24718	MedGen:C0241885	skeletal muscle - myopathy	COSM1497293	.	.	G14846A	EXIT	-	+	Reported	5	P	P	P	damaging
chrM	14846	14846	G	T	MI.8537	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	100	34	G	C	Ggc/Tgc	-2.57	0	0	probably_damaging	1	neutral	0.18	neutral	2.85	deleterious	-10.73	deleterious	-6.67	high_impact	5.5	0.84	neutral	0.03	damaging	3.99	23.60	deleterious	0.03	0.35	0.97	disease	0.95	disease	0.75	disease	0.81	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.14	medium_impact	3.8	high_impact	0.17	0.8	57.63	8.53	0.58	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14846	14846	G	C	MI.8538	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	100	34	G	R	Ggc/Cgc	-2.57	0	0	probably_damaging	1	neutral	0.35	neutral	2.84	deleterious	-9.22	deleterious	-5.93	high_impact	4.8	0.9	neutral	0.04	damaging	3.75	23.30	deleterious	0.03	0.35	0.96	disease	0.93	disease	0.82	disease	0.84	disease	7	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.08	medium_impact	3.17	high_impact	0.31	0.8	57.63	8.53	0.67	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14847	14847	G	C	MI.8539	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	101	34	G	A	gGc/gCc	5.92	1	0	probably_damaging	1	neutral	0.51	neutral	2.91	deleterious	-7.32	deleterious	-4.44	high_impact	5.5	0.84	neutral	0.1	damaging	2.83	21.50	deleterious	0.05	0.35	0.88	disease	0.84	disease	0.75	disease	0.8	disease	6	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.23	medium_impact	3.8	high_impact	0.31	0.8	57.63	8.53	0.76	P	0.83	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8927	8927	C	A	MI.854	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	401	134	P	H	cCt/cAt	3.6	0.99	0	probably_damaging	1	deleterious	0	neutral	3.49	deleterious	-4.31	deleterious	-8.09	high_impact	3.71	0.65	neutral	0.08	damaging	4.12	23.80	deleterious	0.28	0.65	0.8	disease	0.82	disease	0.75	disease	0.75	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	2.08	high_impact	0.73	0.9	49.56	8.76	0.42	N	0.64	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14847	14847	G	T	MI.8540	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	101	34	G	V	gGc/gTc	5.92	1	0	probably_damaging	1	neutral	0.5	neutral	2.85	deleterious	-9.84	deleterious	-6.67	high_impact	5.5	0.84	neutral	0.07	damaging	3.60	23.20	deleterious	0.03	0.35	0.95	disease	0.92	disease	0.77	disease	0.83	disease	7	1	deleterious	0.25	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.22	medium_impact	3.8	high_impact	0.15	0.8	57.63	8.53	0.68	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14847	14847	G	A	MI.8541	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	101	34	G	D	gGc/gAc	5.92	1	0	probably_damaging	1	neutral	0.2	neutral	2.84	deleterious	-8.37	deleterious	-5.19	high_impact	4.61	0.79	neutral	0.05	damaging	3.60	23.20	deleterious	0.03	0.35	0.94	disease	0.93	disease	0.82	disease	0.84	disease	7	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.1	medium_impact	2.99	high_impact	0.17	0.8	57.63	8.53	0.6	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	COSM1138282	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14849	14849	T	G	MI.8542	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	103	35	S	A	Tca/Gca	-11.74	0	0	probably_damaging	0.92	neutral	0.5	neutral	4.53	neutral	-0.63	neutral	-2.22	high_impact	4	0.88	neutral	0.14	damaging	1.67	14.25	neutral	0.17	0.45	0.55	disease	0.78	disease	0.59	disease	0.67	disease	3	0.91	neutral	0.29	neutral	2	deleterious	0.67	deleterious	-1.72	low_impact	0.22	medium_impact	2.44	high_impact	0.57	0.8	57.37	8.66	0.27	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14849	14849	T	A	MI.8543	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	103	35	S	T	Tca/Aca	-11.74	0	0	possibly_damaging	0.86	neutral	0.39	neutral	4.46	neutral	-1.57	neutral	-2.23	high_impact	5.09	0.86	neutral	0.1	damaging	1.72	14.55	neutral	0.21	0.45	0.65	disease	0.82	disease	0.65	disease	0.68	disease	4	0.87	neutral	0.27	neutral	1	deleterious	0.74	deleterious	-1.47	low_impact	0.12	medium_impact	3.43	high_impact	0.68	0.85	57.37	8.66	0.62	P	0.70	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14849	14849	T	C	MI.8544	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	103	35	S	P	Tca/Cca	-11.74	0	0	probably_damaging	0.98	neutral	0.2	neutral	4.41	deleterious	-3.55	deleterious	-3.71	high_impact	4.75	0.93	neutral	0.05	damaging	2.03	16.41	deleterious	0.05	0.35	0.77	disease	0.92	disease	0.75	disease	0.76	disease	5	0.99	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.31	low_impact	-0.1	medium_impact	3.12	high_impact	0.34	0.8	57.37	8.66	0.74	P	1.00	disease_causing_automatic	0	0.12	rs207460004	Pathogenic	Exercise_intolerance,_cardiomyopathy,_and_septooptic_dysplasia	24724	MedGen:C4016599	.	.	.	.	T14849C	EXIT / Septo-Optic Dysplasia	-	+	Cfrm	3	P	P	P	damaging
chrM	14850	14850	C	G	MI.8545	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	104	35	S	W	tCa/tGa	5.69	1	0	probably_damaging	1	neutral	0.19	neutral	4.39	deleterious	-4.41	deleterious	-5.2	high_impact	5.09	0.89	neutral	0.09	damaging	4.04	23.70	deleterious	0.05	0.35	0.94	disease	0.94	disease	0.69	disease	0.81	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.12	medium_impact	3.43	high_impact	0.21	0.8	57.37	8.66	0.71	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14850	14850	C	T	MI.8546	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	104	35	S	L	tCa/tTa	5.69	1	0	probably_damaging	0.99	neutral	0.66	neutral	4.47	neutral	-1.51	deleterious	-4.45	high_impact	4.4	0.88	neutral	0.06	damaging	2.85	21.60	deleterious	0.03	0.35	0.7	disease	0.93	disease	0.61	disease	0.72	disease	4	0.99	deleterious	0.34	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	0.38	medium_impact	2.8	high_impact	0.63	0.8	57.37	8.66	0.51	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14852	14852	C	G	MI.8547	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	106	36	L	V	Ctc/Gtc	-11.05	0	0	probably_damaging	0.98	neutral	0.47	neutral	4.4	neutral	-1.5	neutral	-2.18	high_impact	4.21	0.95	neutral	0.1	damaging	1.59	13.81	neutral	0.2	0.45	0.67	disease	0.7	disease	0.64	disease	0.66	disease	3	0.98	neutral	0.25	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0.19	medium_impact	2.63	high_impact	0.57	0.8	58.16	8.7	0.32	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14852	14852	C	T	MI.8548	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	106	36	L	F	Ctc/Ttc	-11.05	0	0	probably_damaging	1	neutral	0.72	neutral	4.28	deleterious	-3.33	deleterious	-2.95	high_impact	3.83	0.96	neutral	0.09	damaging	3.62	23.20	deleterious	0.13	0.4	0.62	disease	0.82	disease	0.59	disease	0.67	disease	3	1	deleterious	0.36	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.44	medium_impact	2.28	high_impact	0.62	0.8	58.16	8.7	0.21	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14852	14852	C	A	MI.8549	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	106	36	L	I	Ctc/Atc	-11.05	0	0	probably_damaging	0.99	neutral	0.52	neutral	4.46	neutral	-0.98	neutral	-1.43	high_impact	3.61	0.96	neutral	0.27	damaging	3.51	23.10	deleterious	0.23	0.45	0.59	disease	0.77	disease	0.53	disease	0.58	disease	2	0.99	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.24	medium_impact	2.08	high_impact	0.64	0.8	58.16	8.7	0.25	N	0.86	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8927	8927	C	T	MI.855	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	401	134	P	L	cCt/cTt	3.6	0.99	0	probably_damaging	1	deleterious	0	neutral	3.45	deleterious	-3.63	deleterious	-8.99	high_impact	4.26	0.6	damaging	0.09	damaging	4.32	24.00	deleterious	0.43	0.65	0.81	disease	0.8	disease	0.7	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	2.55	high_impact	0.79	0.9	49.56	8.76	0.45	N	0.95	disease_causing	1	0.33	rs28660616	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14853	14853	T	A	MI.8550	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	107	36	L	H	cTc/cAc	-0.04	0	0	probably_damaging	1	neutral	0.49	neutral	4.24	deleterious	-5.33	deleterious	-5.2	high_impact	5.42	0.93	neutral	0.07	damaging	4.08	23.70	deleterious	0.04	0.35	0.96	disease	0.86	disease	0.72	disease	0.82	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.21	medium_impact	3.73	high_impact	0.40	0.8	58.16	8.7	0.71	P	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14853	14853	T	G	MI.8551	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	107	36	L	R	cTc/cGc	-0.04	0	0	probably_damaging	1	neutral	0.31	neutral	4.25	deleterious	-4.77	deleterious	-4.46	high_impact	5.07	0.94	neutral	0.06	damaging	3.96	23.60	deleterious	0.02	0.35	0.94	disease	0.91	disease	0.75	disease	0.83	disease	7	1	deleterious	0.16	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.03	medium_impact	3.41	high_impact	0.22	0.8	58.16	8.7	0.74	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14853	14853	T	C	MI.8552	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	107	36	L	P	cTc/cCc	-0.04	0	0	probably_damaging	1	neutral	0.18	neutral	4.24	deleterious	-5.34	deleterious	-5.19	high_impact	5.07	0.96	neutral	0.06	damaging	3.73	23.30	deleterious	0.02	0.35	0.95	disease	0.88	disease	0.74	disease	0.83	disease	7	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.14	medium_impact	3.41	high_impact	0.24	0.8	58.16	8.7	0.7	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14855	14855	C	T	MI.8553	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	109	37	L	F	Ctt/Ttt	-13.35	0	0	probably_damaging	1	neutral	0.36	neutral	4.26	neutral	-2.99	deleterious	-2.99	high_impact	4.72	0.95	neutral	0.09	damaging	3.53	23.10	deleterious	0.14	0.4	0.75	disease	0.79	disease	0.64	disease	0.68	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.09	medium_impact	3.09	high_impact	0.45	0.8	56.84	8.26	0.63	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14855	14855	C	G	MI.8554	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	109	37	L	V	Ctt/Gtt	-13.35	0	0	probably_damaging	0.96	neutral	0.27	neutral	4.41	neutral	-0.82	neutral	-2.23	high_impact	4.52	0.96	neutral	0.12	damaging	1.50	13.29	neutral	0.25	0.45	0.56	disease	0.65	disease	0.63	disease	0.66	disease	3	0.97	neutral	0.16	neutral	2	deleterious	0.74	deleterious	-2.02	low_impact	-0.01	medium_impact	2.91	high_impact	0.47	0.8	56.84	8.26	0.41	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14855	14855	C	A	MI.8555	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	109	37	L	I	Ctt/Att	-13.35	0	0	probably_damaging	0.98	neutral	0.28	neutral	4.31	neutral	-2.01	neutral	-1.48	high_impact	4.32	0.93	neutral	0.12	damaging	2.39	18.78	deleterious	0.3	0.45	0.61	disease	0.74	disease	0.55	disease	0.64	disease	3	0.99	deleterious	0.15	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0	medium_impact	2.73	high_impact	0.59	0.8	56.84	8.26	0.37	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14856	14856	T	A	MI.8556	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	110	37	L	H	cTt/cAt	-0.27	0	0	probably_damaging	1	neutral	0.23	neutral	4.23	deleterious	-4.35	deleterious	-5.24	high_impact	5.42	0.93	neutral	0.08	damaging	3.87	23.50	deleterious	0.04	0.35	0.86	disease	0.84	disease	0.72	disease	0.76	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.06	medium_impact	3.73	high_impact	0.34	0.8	56.84	8.26	0.67	P	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14856	14856	T	G	MI.8557	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	110	37	L	R	cTt/cGt	-0.27	0	0	probably_damaging	1	neutral	0.13	neutral	4.24	deleterious	-3.68	deleterious	-4.49	high_impact	5.07	0.94	neutral	0.06	damaging	3.88	23.50	deleterious	0.03	0.35	0.78	disease	0.89	disease	0.74	disease	0.73	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.23	medium_impact	3.41	high_impact	0.26	0.8	56.84	8.26	0.71	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14856	14856	T	C	MI.8558	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	110	37	L	P	cTt/cCt	-0.27	0	0	probably_damaging	1	neutral	0.07	neutral	4.23	deleterious	-4.29	deleterious	-5.24	high_impact	4.32	0.94	neutral	0.06	damaging	3.68	23.30	deleterious	0.03	0.35	0.82	disease	0.86	disease	0.75	disease	0.76	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.39	medium_impact	2.73	high_impact	0.27	0.8	56.84	8.26	0.47	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14858	14858	G	T	MI.8559	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	112	38	G	C	Ggc/Tgc	-2.11	0	0	probably_damaging	1	neutral	0.19	neutral	4.52	neutral	-2.16	deleterious	-6.25	high_impact	4.95	0.91	neutral	0.2	damaging	3.92	23.50	deleterious	0.05	0.35	0.88	disease	0.94	disease	0.58	disease	0.72	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.12	medium_impact	3.3	high_impact	0.19	0.8	21.32	40.51	0.64	P	0.89	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8929	8929	A	G	MI.856	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	403	135	T	A	Aca/Gca	-14.68	0	0	probably_damaging	0.99	neutral	0.6	neutral	3.91	neutral	0.45	deleterious	-2.93	low_impact	1.05	0.94	neutral	0.94	neutral	2.32	18.32	deleterious	0.56	0.65	0.35	neutral	0.25	neutral	0.3	neutral	0.46	neutral	1	0.99	deleterious	0.31	neutral	-2	neutral	0.64	deleterious	-2.65	low_impact	0.39	medium_impact	-0.2	medium_impact	0.45	0.9	17.7	17.51	0.34	N	0.25	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14858	14858	G	A	MI.8560	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	112	38	G	S	Ggc/Agc	-2.11	0	0	probably_damaging	1	neutral	0.43	neutral	4.61	neutral	0.05	deleterious	-4.12	medium_impact	3.02	0.85	neutral	0.32	neutral	3.90	23.50	deleterious	0.11	0.4	0.62	disease	0.84	disease	0.5	neutral	0.6	disease	2	1	deleterious	0.22	neutral	1	deleterious	0.82	deleterious	-3.53	low_impact	0.16	medium_impact	1.55	medium_impact	0.57	0.8	21.32	40.51	0.26	N	0.72	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14858	14858	G	C	MI.8561	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	112	38	G	R	Ggc/Cgc	-2.11	0	0	probably_damaging	1	neutral	0.32	neutral	4.54	neutral	-1.63	deleterious	-5.59	high_impact	4.74	0.9	neutral	0.21	damaging	3.68	23.30	deleterious	0.04	0.35	0.85	disease	0.92	disease	0.7	disease	0.75	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.05	medium_impact	3.11	high_impact	0.51	0.8	21.32	40.51	0.65	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14859	14859	G	A	MI.8562	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	113	38	G	D	gGc/gAc	5	1	0.01	probably_damaging	1	neutral	0.19	neutral	4.52	neutral	-2.62	deleterious	-4.95	high_impact	5.29	0.86	neutral	0.27	damaging	3.60	23.20	deleterious	0.05	0.35	0.84	disease	0.91	disease	0.69	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.12	medium_impact	3.61	high_impact	0.13	0.8	21.32	40.51	0.74	P	0.90	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14859	14859	G	C	MI.8563	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	113	38	G	A	gGc/gCc	5	1	0.01	probably_damaging	0.99	neutral	0.48	neutral	4.69	neutral	1.33	deleterious	-4.03	medium_impact	2.94	0.95	neutral	0.59	neutral	1.58	13.76	neutral	0.13	0.4	0.39	neutral	0.75	disease	0.49	neutral	0.41	neutral	2	0.99	deleterious	0.25	neutral	1	deleterious	0.77	deleterious	-2.59	low_impact	0.2	medium_impact	1.48	medium_impact	0.40	0.8	21.32	40.51	0.51	N	0.38	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14859	14859	G	T	MI.8564	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	113	38	G	V	gGc/gTc	5	1	0.01	probably_damaging	1	neutral	0.51	neutral	4.64	neutral	0.87	deleterious	-6.21	high_impact	3.98	0.87	neutral	0.36	neutral	3.61	23.20	deleterious	0.05	0.35	0.77	disease	0.89	disease	0.6	disease	0.69	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.23	medium_impact	2.42	high_impact	0.12	0.8	21.32	40.51	0.47	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14861	14861	G	C	MI.8565	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	115	39	A	P	Gcc/Ccc	-13.35	0	0.01	possibly_damaging	0.6	neutral	0.2	neutral	4.57	neutral	-2.08	neutral	-1.67	medium_impact	2.38	0.94	neutral	0.4	neutral	3.47	23.00	deleterious	0.05	0.35	0.63	disease	0.82	disease	0.62	disease	0.77	disease	5	0.8	neutral	0.3	neutral	0	NA	0.66	deleterious	-0.9	medium_impact	-0.1	medium_impact	0.97	medium_impact	0.48	0.8	24.74	31.68	0.31	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14861	14861	G	T	MI.8566	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	115	39	A	S	Gcc/Tcc	-13.35	0	0.01	benign	0.22	neutral	0.44	neutral	4.63	neutral	-0.43	neutral	-0.88	medium_impact	1.96	0.94	neutral	0.65	neutral	1.96	15.96	deleterious	0.22	0.45	0.4	neutral	0.38	neutral	0.47	neutral	0.47	neutral	1	0.47	neutral	0.61	deleterious	-3	neutral	0.22	neutral	-0.22	medium_impact	0.17	medium_impact	0.59	medium_impact	0.32	0.8	24.74	31.68	0.34	N	0.54	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14861	14861	G	A	MI.8567	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	115	39	A	T	Gcc/Acc	-13.35	0	0.01	benign	0.01	neutral	0.42	neutral	4.67	neutral	-0.36	neutral	-0.2	neutral_impact	0.59	0.99	neutral	0.77	neutral	2.33	18.33	deleterious	0.23	0.45	0.34	neutral	0.31	neutral	0.39	neutral	0.46	neutral	1	0.57	neutral	0.71	deleterious	-6	neutral	0.10	neutral	1.13	medium_impact	0.15	medium_impact	-0.66	medium_impact	0.70	0.85	24.74	31.68	0.4	N	0.43	polymorphism	1	0.01	rs2853505	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14862	14862	C	A	MI.8568	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	116	39	A	D	gCc/gAc	-3.71	0	0	possibly_damaging	0.52	neutral	0.21	neutral	4.56	neutral	0.15	neutral	-2.24	medium_impact	2.93	0.93	neutral	0.5	neutral	4.17	23.80	deleterious	0.03	0.35	0.7	disease	0.7	disease	0.63	disease	0.72	disease	4	0.77	neutral	0.35	neutral	0	NA	0.59	deleterious	-0.76	medium_impact	-0.09	medium_impact	1.47	medium_impact	0.45	0.8	24.74	31.68	0.37	N	0.63	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14862	14862	C	G	MI.8569	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	116	39	A	G	gCc/gGc	-3.71	0	0	benign	0.22	neutral	0.41	neutral	4.58	neutral	-1.52	neutral	-2.29	low_impact	1.89	0.93	neutral	0.61	neutral	2.22	17.66	deleterious	0.21	0.45	0.55	disease	0.39	neutral	0.48	neutral	0.61	disease	2	0.51	neutral	0.6	deleterious	-6	neutral	0.27	neutral	-0.22	medium_impact	0.14	medium_impact	0.52	medium_impact	0.54	0.8	24.74	31.68	0.32	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8929	8929	A	C	MI.857	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	403	135	T	P	Aca/Cca	-14.68	0	0	probably_damaging	1	neutral	0.27	neutral	3.89	neutral	-0.56	deleterious	-4.17	low_impact	1.06	0.9	neutral	0.7	neutral	2.46	19.24	deleterious	0.2	0.65	0.69	disease	0.64	disease	0.27	neutral	0.5	neutral	0	1	deleterious	0.14	neutral	-2	neutral	0.75	deleterious	-3.6	low_impact	0.05	medium_impact	-0.19	medium_impact	0.46	0.9	17.7	17.51	0.39	N	0.93	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14862	14862	C	T	MI.8570	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	116	39	A	V	gCc/gTc	-3.71	0	0	benign	0.22	neutral	0.51	neutral	4.77	neutral	0.21	neutral	1.48	neutral_impact	-0.43	0.98	neutral	0.9	neutral	2.20	17.49	deleterious	0.2	0.45	0.14	neutral	0.28	neutral	0.33	neutral	0.42	neutral	2	0.39	neutral	0.65	deleterious	-6	neutral	0.21	neutral	-0.22	medium_impact	0.23	medium_impact	-1.58	low_impact	0.75	0.85	24.74	31.68	0.35	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14864	14864	T	G	MI.8571	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	118	40	C	G	Tgc/Ggc	-9.22	0	0	probably_damaging	1	neutral	0.46	neutral	4.51	neutral	-2.57	deleterious	-8.78	high_impact	4.62	0.97	neutral	0.49	neutral	3.15	22.60	deleterious	0.1	0.4	0.83	disease	0.91	disease	0.68	disease	0.69	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.18	medium_impact	3	high_impact	0.26	0.8	59.47	8.73	0.57	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14864	14864	T	C	MI.8572	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	118	40	C	R	Tgc/Cgc	-9.22	0	0	probably_damaging	1	neutral	0.24	neutral	4.51	neutral	-2.63	deleterious	-8.71	high_impact	4.76	0.93	neutral	0.38	neutral	3.33	22.90	deleterious	0.05	0.35	0.83	disease	0.96	disease	0.77	disease	0.78	disease	6	1	deleterious	0.12	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.05	medium_impact	3.13	high_impact	0.12	0.8	59.47	8.73	0.76	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	T14864C	MELAS	-	+	Cfrm	1	.	P	P	damaging
chrM	14864	14864	T	A	MI.8573	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	118	40	C	S	Tgc/Agc	-9.22	0	0	probably_damaging	1	neutral	0.36	neutral	4.57	neutral	-0.88	deleterious	-7.26	medium_impact	3.38	0.94	neutral	0.47	neutral	3.34	22.90	deleterious	0.12	0.4	0.73	disease	0.91	disease	0.63	disease	0.68	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.86	deleterious	-3.53	low_impact	0.09	medium_impact	1.88	medium_impact	0.33	0.8	59.47	8.73	0.38	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14865	14865	G	A	MI.8574	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	119	40	C	Y	tGc/tAc	5.69	1	0	probably_damaging	1	neutral	0.57	neutral	4.52	neutral	-2.13	deleterious	-7.98	high_impact	4.76	0.94	neutral	0.41	neutral	3.31	22.90	deleterious	0.07	0.35	0.8	disease	0.96	disease	0.71	disease	0.77	disease	5	1	deleterious	0.29	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.29	medium_impact	3.13	high_impact	0.32	0.8	59.47	8.73	0.65	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14865	14865	G	T	MI.8575	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	119	40	C	F	tGc/tTc	5.69	1	0	probably_damaging	1	neutral	0.62	neutral	4.56	neutral	-1.08	deleterious	-7.95	medium_impact	3.25	0.95	neutral	0.45	neutral	3.55	23.10	deleterious	0.07	0.35	0.69	disease	0.96	disease	0.67	disease	0.77	disease	5	1	deleterious	0.31	neutral	1	deleterious	0.88	deleterious	-3.53	low_impact	0.34	medium_impact	1.76	medium_impact	0.28	0.8	59.47	8.73	0.49	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14865	14865	G	C	MI.8576	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	119	40	C	S	tGc/tCc	5.69	1	0	probably_damaging	1	neutral	0.36	neutral	4.57	neutral	-0.88	deleterious	-7.26	medium_impact	3.38	0.94	neutral	0.47	neutral	2.86	21.70	deleterious	0.12	0.4	0.73	disease	0.91	disease	0.63	disease	0.68	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.86	deleterious	-3.53	low_impact	0.09	medium_impact	1.88	medium_impact	0.33	0.8	59.47	8.73	0.54	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14866	14866	C	G	MI.8577	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	120	40	C	W	tgC/tgG	7.07	1	0	probably_damaging	1	neutral	0.1	neutral	4.5	deleterious	-3.93	deleterious	-7.98	high_impact	4.27	0.94	neutral	0.39	neutral	4.10	23.70	deleterious	0.06	0.35	0.92	disease	0.96	disease	0.74	disease	0.69	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.3	medium_impact	2.68	high_impact	0.27	0.8	59.47	8.73	0.61	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14866	14866	C	A	MI.8578	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	120	40	C	W	tgC/tgA	7.07	1	0	probably_damaging	1	neutral	0.1	neutral	4.5	deleterious	-3.93	deleterious	-7.98	high_impact	4.27	0.94	neutral	0.39	neutral	4.43	24.20	deleterious	0.06	0.35	0.92	disease	0.96	disease	0.74	disease	0.69	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.3	medium_impact	2.68	high_impact	0.27	0.8	59.47	8.73	0.61	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14867	14867	C	A	MI.8579	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	121	41	L	M	Ctg/Atg	-0.73	0	0.01	probably_damaging	1	neutral	0.14	neutral	4.17	deleterious	-4.04	neutral	-1.52	high_impact	4.07	0.94	neutral	0.1	damaging	3.45	23.00	deleterious	0.14	0.4	0.7	disease	0.72	disease	0.59	disease	0.64	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	-0.21	medium_impact	2.5	high_impact	0.42	0.8	58.95	8.74	0.41	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8929	8929	A	T	MI.858	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	403	135	T	S	Aca/Tca	-14.68	0	0	probably_damaging	0.99	neutral	0.51	neutral	3.89	neutral	-0.45	deleterious	-2.51	low_impact	1.69	0.86	neutral	0.73	neutral	3.40	23.00	deleterious	0.52	0.65	0.41	neutral	0.36	neutral	0.3	neutral	0.48	neutral	1	0.99	deleterious	0.26	neutral	-2	neutral	0.67	deleterious	-2.65	low_impact	0.3	medium_impact	0.35	medium_impact	0.61	0.9	17.7	17.51	0.32	N	0.16	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14867	14867	C	G	MI.8580	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	121	41	L	V	Ctg/Gtg	-0.73	0	0.01	probably_damaging	0.98	neutral	0.23	neutral	4.21	deleterious	-3.31	neutral	-2.29	high_impact	4.79	0.95	neutral	0.11	damaging	1.60	13.85	neutral	0.15	0.45	0.68	disease	0.71	disease	0.62	disease	0.65	disease	3	0.98	deleterious	0.13	neutral	2	deleterious	0.79	deleterious	-2.31	low_impact	-0.06	medium_impact	3.16	high_impact	0.51	0.8	58.95	8.74	0.65	P	0.91	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14868	14868	T	A	MI.8581	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	122	41	L	Q	cTg/cAg	-3.03	0	0	probably_damaging	1	neutral	0.15	neutral	4.13	deleterious	-5.89	deleterious	-4.58	high_impact	5.48	0.94	neutral	0.07	damaging	3.97	23.60	deleterious	0.03	0.35	0.93	disease	0.88	disease	0.67	disease	0.71	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.19	medium_impact	3.78	high_impact	0.23	0.8	58.95	8.74	0.65	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14868	14868	T	G	MI.8582	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	122	41	L	R	cTg/cGg	-3.03	0	0	probably_damaging	1	neutral	0.07	neutral	4.13	deleterious	-5.85	deleterious	-4.58	high_impact	5.48	0.94	neutral	0.06	damaging	3.96	23.60	deleterious	0.02	0.35	0.94	disease	0.93	disease	0.76	disease	0.73	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.39	medium_impact	3.78	high_impact	0.15	0.8	58.95	8.74	0.68	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14868	14868	T	C	MI.8583	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	122	41	L	P	cTg/cCg	-3.03	0	0	probably_damaging	1	deleterious	0.04	neutral	4.12	deleterious	-6.4	deleterious	-5.34	high_impact	4.58	0.94	neutral	0.05	damaging	3.66	23.20	deleterious	0.02	0.35	0.95	disease	0.88	disease	0.76	disease	0.74	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-3.53	low_impact	-0.53	medium_impact	2.97	high_impact	0.25	0.8	58.95	8.74	0.51	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14870	14870	A	T	MI.8584	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	124	42	I	F	Atc/Ttc	-1.88	0	0	benign	0.2	neutral	0.35	neutral	4.47	neutral	-2.12	deleterious	-2.55	medium_impact	2.68	0.95	neutral	0.5	neutral	1.80	15.01	deleterious	0.13	0.4	0.42	neutral	0.81	disease	0.59	disease	0.67	disease	3	0.58	neutral	0.58	deleterious	-3	neutral	0.42	neutral	-0.17	medium_impact	0.08	medium_impact	1.24	medium_impact	0.47	0.8	18.42	22.46	0.32	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14870	14870	A	G	MI.8585	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	124	42	I	V	Atc/Gtc	-1.88	0	0	benign	0	neutral	0.17	neutral	4.67	neutral	-0.04	neutral	-0.4	low_impact	0.88	0.99	neutral	0.93	neutral	-0.43	0.34	neutral	0.34	0.5	0.19	neutral	0.27	neutral	0.35	neutral	0.42	neutral	2	0.83	neutral	0.59	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	-0.15	medium_impact	-0.39	medium_impact	0.46	0.8	18.42	22.46	0.48	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14870	14870	A	C	MI.8586	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	124	42	I	L	Atc/Ctc	-1.88	0	0	benign	0.01	neutral	1	neutral	4.6	neutral	-0.49	neutral	-1.08	low_impact	1.56	0.97	neutral	0.72	neutral	0.67	8.62	deleterious	0.23	0.45	0.34	neutral	0.68	disease	0.38	neutral	0.36	neutral	3	0.01	neutral	1	deleterious	-6	neutral	0.15	neutral	1.13	medium_impact	1.85	high_impact	0.22	medium_impact	0.44	0.8	18.42	22.46	0.22	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14871	14871	T	C	MI.8587	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	125	42	I	T	aTc/aCc	-1.65	0	0	benign	0	neutral	0.37	neutral	4.48	neutral	-1.74	deleterious	-2.84	medium_impact	2.06	0.98	neutral	0.9	neutral	0.33	5.98	deleterious	0.08	0.35	0.48	neutral	0.62	disease	0.43	neutral	0.35	neutral	3	0.63	neutral	0.69	deleterious	-3	neutral	0.16	neutral	2.07	high_impact	0.1	medium_impact	0.68	medium_impact	0.35	0.8	18.42	22.46	0.36	N	0.78	polymorphism	1	0.03	rs28660155	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14871	14871	T	G	MI.8588	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	125	42	I	S	aTc/aGc	-1.65	0	0	benign	0.14	neutral	0.21	neutral	4.45	neutral	-2.46	deleterious	-3.51	medium_impact	2.76	0.97	neutral	0.57	neutral	2.40	18.82	deleterious	0.05	0.35	0.56	disease	0.83	disease	0.57	disease	0.66	disease	3	0.76	neutral	0.54	deleterious	-3	neutral	0.34	neutral	0	medium_impact	-0.09	medium_impact	1.31	medium_impact	0.27	0.8	18.42	22.46	0.36	N	0.70	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14871	14871	T	A	MI.8589	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	125	42	I	N	aTc/aAc	-1.65	0	0	benign	0.22	neutral	0.06	neutral	4.42	deleterious	-3.96	deleterious	-4.39	high_impact	4.55	0.93	neutral	0.48	neutral	2.65	20.50	deleterious	0.1	0.4	0.73	disease	0.86	disease	0.59	disease	0.69	disease	4	0.93	neutral	0.42	neutral	-2	neutral	0.54	deleterious	-0.22	medium_impact	-0.43	medium_impact	2.94	high_impact	0.29	0.8	18.42	22.46	0.5	N	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8930	8930	C	A	MI.859	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	404	135	T	K	aCa/aAa	-0.8	0	0	probably_damaging	1	neutral	0.34	neutral	3.88	neutral	0.33	deleterious	-3.99	medium_impact	2.4	0.85	neutral	0.46	neutral	4.36	24.10	deleterious	0.25	0.65	0.72	disease	0.72	disease	0.63	disease	0.69	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	0.13	medium_impact	0.96	medium_impact	0.70	0.9	17.7	17.51	0.25	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14872	14872	C	A	MI.8590	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	126	42	I	M	atC/atA	-0.73	0	0.03	benign	0.35	neutral	0.13	neutral	4.48	neutral	-1.94	neutral	-1.5	low_impact	1.01	0.93	neutral	0.89	neutral	0.69	8.73	deleterious	0.25	0.45	0.4	neutral	0.47	neutral	0.35	neutral	0.44	neutral	1	0.85	neutral	0.39	neutral	-6	neutral	0.29	neutral	-0.48	medium_impact	-0.23	medium_impact	-0.28	medium_impact	0.58	0.8	18.42	22.46	0.43	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14872	14872	C	G	MI.8591	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	126	42	I	M	atC/atG	-0.73	0	0.03	benign	0.35	neutral	0.13	neutral	4.48	neutral	-1.94	neutral	-1.5	low_impact	1.01	0.93	neutral	0.89	neutral	0.22	4.88	deleterious	0.25	0.45	0.4	neutral	0.47	neutral	0.35	neutral	0.44	neutral	1	0.85	neutral	0.39	neutral	-6	neutral	0.29	neutral	-0.48	medium_impact	-0.23	medium_impact	-0.28	medium_impact	0.58	0.8	18.42	22.46	0.42	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14873	14873	C	G	MI.8592	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	127	43	L	V	Ctc/Gtc	-14.04	0	0	benign	0.04	neutral	0.42	neutral	4.67	neutral	-0.25	neutral	0.15	neutral_impact	0.5	0.97	neutral	0.87	neutral	-0.03	2.29	deleterious	0.22	0.45	0.24	neutral	0.24	neutral	0.28	neutral	0.44	neutral	1	0.55	neutral	0.69	deleterious	-6	neutral	0.13	neutral	0.56	medium_impact	0.15	medium_impact	-0.74	medium_impact	0.61	0.8	22.11	23.68	0.45	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14873	14873	C	T	MI.8593	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	127	43	L	F	Ctc/Ttc	-14.04	0	0	possibly_damaging	0.47	neutral	0.37	neutral	4.52	neutral	-1.96	neutral	-1.43	low_impact	1.92	0.97	neutral	0.65	neutral	3.58	23.20	deleterious	0.17	0.45	0.37	neutral	0.51	disease	0.44	neutral	0.48	neutral	0	0.59	neutral	0.45	neutral	-3	neutral	0.56	deleterious	-0.68	medium_impact	0.1	medium_impact	0.55	medium_impact	0.56	0.8	22.11	23.68	0.42	N	0.53	polymorphism	1	0.02	rs879056276	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14873	14873	C	A	MI.8594	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	127	43	L	I	Ctc/Atc	-14.04	0	0	benign	0.02	neutral	0.55	neutral	4.72	neutral	0.22	neutral	0.05	neutral_impact	-0.66	0.95	neutral	0.95	neutral	-0.38	0.42	neutral	0.24	0.45	0.15	neutral	0.07	neutral	0.21	neutral	0.21	neutral	6	0.43	neutral	0.77	deleterious	-6	neutral	0.09	neutral	0.85	medium_impact	0.27	medium_impact	-1.79	low_impact	0.56	0.8	22.11	23.68	0.42	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14874	14874	T	G	MI.8595	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	128	43	L	R	cTc/cGc	-2.57	0	0	possibly_damaging	0.84	neutral	0.14	neutral	4.46	deleterious	-3.49	neutral	-1.92	high_impact	3.76	0.94	neutral	0.49	neutral	3.93	23.50	deleterious	0.02	0.35	0.63	disease	0.8	disease	0.63	disease	0.74	disease	5	0.93	neutral	0.15	neutral	1	deleterious	0.78	deleterious	-1.4	low_impact	-0.21	medium_impact	2.22	high_impact	0.31	0.8	22.11	23.68	0.46	N	0.87	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14874	14874	T	A	MI.8596	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	128	43	L	H	cTc/cAc	-2.57	0	0	probably_damaging	0.92	neutral	0.22	neutral	4.46	deleterious	-4.02	neutral	-2.46	high_impact	3.76	0.93	neutral	0.5	neutral	3.96	23.60	deleterious	0.04	0.35	0.71	disease	0.59	disease	0.58	disease	0.68	disease	4	0.94	neutral	0.15	neutral	2	deleterious	0.73	deleterious	-1.72	low_impact	-0.08	medium_impact	2.22	high_impact	0.28	0.8	22.11	23.68	0.46	N	0.72	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14874	14874	T	C	MI.8597	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	128	43	L	P	cTc/cCc	-2.57	0	0	probably_damaging	0.95	neutral	0.08	neutral	4.46	deleterious	-4.07	neutral	-2.06	high_impact	3.76	0.93	neutral	0.39	neutral	3.70	23.30	deleterious	0.02	0.35	0.71	disease	0.84	disease	0.63	disease	0.77	disease	5	0.98	deleterious	0.07	neutral	2	deleterious	0.83	deleterious	-1.92	low_impact	-0.35	medium_impact	2.22	high_impact	0.25	0.8	22.11	23.68	0.43	N	0.94	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14876	14876	C	A	MI.8598	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	130	44	Q	K	Caa/Aaa	-20	0	0	probably_damaging	0.98	neutral	0.21	neutral	4.34	neutral	-2.06	deleterious	-3.16	high_impact	5.55	0.84	neutral	0.1	damaging	1.95	15.91	deleterious	0.16	0.45	0.71	disease	0.88	disease	0.77	disease	0.74	disease	5	0.99	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-2.31	low_impact	-0.09	medium_impact	3.85	high_impact	0.59	0.8	57.89	8.73	0.7	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14876	14876	C	G	MI.8599	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	130	44	Q	E	Caa/Gaa	-20	0	0	probably_damaging	0.96	neutral	0.19	neutral	4.37	neutral	-2.21	neutral	-2.37	high_impact	5.21	0.83	neutral	0.11	damaging	1.12	11.33	neutral	0.27	0.45	0.71	disease	0.78	disease	0.74	disease	0.7	disease	4	0.97	neutral	0.12	neutral	2	deleterious	0.82	deleterious	-2.02	low_impact	-0.12	medium_impact	3.54	high_impact	0.64	0.8	57.89	8.73	0.66	P	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8564	8564	C	T	MI.86	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	38	13	T	M	aCa/aTa	0.13	0	0	probably_damaging	1	neutral	0.07	neutral	4.51	neutral	-1.96	deleterious	-2.94	low_impact	1.9	0.91	neutral	0.93	neutral	8.54	35.00	deleterious	0.41	0.65	0.49	neutral	0.68	disease	0.63	disease	0.53	disease	1	1	deleterious	0.04	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	-0.34	medium_impact	0.53	medium_impact	0.77	0.9	15.49	16.77	0.43	N	0.85	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8930	8930	C	T	MI.860	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	404	135	T	M	aCa/aTa	-0.8	0	0	probably_damaging	1	neutral	0.26	neutral	3.88	neutral	-0.97	deleterious	-3.19	low_impact	1.58	0.94	neutral	0.71	neutral	2.91	21.90	deleterious	0.33	0.65	0.6	disease	0.43	neutral	0.32	neutral	0.6	disease	2	1	deleterious	0.13	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.04	medium_impact	0.26	medium_impact	0.69	0.9	17.7	17.51	0.41	N	0.50	polymorphism	1	0.06	.	.	.	.	.	pituitary adenoma	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14877	14877	A	T	MI.8600	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	131	44	Q	L	cAa/cTa	7.07	1	0	probably_damaging	0.98	neutral	1	neutral	4.41	neutral	-0.7	deleterious	-5.53	high_impact	4.66	0.86	neutral	0.09	damaging	1.85	15.29	deleterious	0.06	0.35	0.88	disease	0.9	disease	0.68	disease	0.66	disease	3	0.98	deleterious	0.51	deleterious	2	deleterious	0.87	deleterious	-2.31	low_impact	1.85	high_impact	3.04	high_impact	0.19	0.8	57.89	8.73	0.56	P	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14877	14877	A	C	MI.8601	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	131	44	Q	P	cAa/cCa	7.07	1	0	probably_damaging	1	neutral	0.15	neutral	4.27	neutral	-1.17	deleterious	-4.73	high_impact	4.86	0.83	neutral	0.07	damaging	2.79	21.30	deleterious	0.04	0.35	0.9	disease	0.89	disease	0.77	disease	0.69	disease	4	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.19	medium_impact	3.22	high_impact	0.33	0.8	57.89	8.73	0.77	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14877	14877	A	G	MI.8602	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	131	44	Q	R	cAa/cGa	7.07	1	0	probably_damaging	0.99	neutral	0.25	neutral	4.31	neutral	-2.42	deleterious	-3.16	high_impact	5.55	0.84	neutral	0.1	damaging	1.54	13.51	neutral	0.17	0.45	0.75	disease	0.88	disease	0.78	disease	0.73	disease	5	0.99	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-2.59	low_impact	-0.04	medium_impact	3.85	high_impact	0.34	0.8	57.89	8.73	0.78	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14878	14878	A	T	MI.8603	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	132	44	Q	H	caA/caT	6.61	1	0	probably_damaging	1	neutral	0.44	neutral	4.28	deleterious	-3.19	deleterious	-3.94	high_impact	5.21	0.81	neutral	0.08	damaging	1.74	14.66	neutral	0.16	0.45	0.9	disease	0.82	disease	0.79	disease	0.7	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.17	medium_impact	3.54	high_impact	0.70	0.85	57.89	8.73	0.81	P	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14878	14878	A	C	MI.8604	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	132	44	Q	H	caA/caC	6.61	1	0	probably_damaging	1	neutral	0.44	neutral	4.28	deleterious	-3.19	deleterious	-3.94	high_impact	5.21	0.81	neutral	0.08	damaging	1.58	13.72	neutral	0.16	0.45	0.9	disease	0.82	disease	0.79	disease	0.7	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.17	medium_impact	3.54	high_impact	0.70	0.85	57.89	8.73	0.8	P	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14879	14879	A	T	MI.8605	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	133	45	I	F	Atc/Ttc	1.33	1	0	benign	0.43	neutral	0.86	neutral	4.31	deleterious	-3.12	deleterious	-3.11	high_impact	4.12	0.85	neutral	0.36	neutral	1.78	14.86	neutral	0.08	0.35	0.77	disease	0.83	disease	0.64	disease	0.67	disease	3	0.32	neutral	0.72	deleterious	-2	neutral	0.64	deleterious	-0.62	medium_impact	0.65	medium_impact	2.55	high_impact	0.61	0.8	55.53	8.5	0.37	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14879	14879	A	C	MI.8606	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	133	45	I	L	Atc/Ctc	1.33	1	0	benign	0.04	neutral	0.89	neutral	4.42	neutral	-0.99	neutral	-1.51	medium_impact	1.99	0.84	neutral	0.34	neutral	1.58	13.74	neutral	0.31	0.45	0.39	neutral	0.69	disease	0.41	neutral	0.2	neutral	6	0.04	neutral	0.93	deleterious	-3	neutral	0.21	neutral	0.56	medium_impact	0.71	medium_impact	0.61	medium_impact	0.61	0.8	55.53	8.5	0.34	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14879	14879	A	G	MI.8607	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	133	45	I	V	Atc/Gtc	1.33	1	0	benign	0.02	neutral	0.53	neutral	4.58	neutral	-0.88	neutral	-0.66	medium_impact	2.73	0.87	neutral	0.6	neutral	0.83	9.66	deleterious	0.48	0.55	0.42	neutral	0.45	neutral	0.45	neutral	0.39	neutral	2	0.45	neutral	0.76	deleterious	-3	neutral	0.17	neutral	0.85	medium_impact	0.25	medium_impact	1.29	medium_impact	0.61	0.8	55.53	8.5	0.46	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14880	14880	T	C	MI.8608	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	134	45	I	T	aTc/aCc	6.61	1	0	benign	0.01	neutral	0.42	neutral	4.32	deleterious	-3.26	deleterious	-3.71	medium_impact	3.11	0.9	neutral	0.44	neutral	1.64	14.07	neutral	0.05	0.35	0.77	disease	0.7	disease	0.55	disease	0.32	neutral	4	0.57	neutral	0.71	deleterious	-3	neutral	0.27	neutral	1.13	medium_impact	0.15	medium_impact	1.63	medium_impact	0.37	0.8	55.53	8.5	0.59	P	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14880	14880	T	G	MI.8609	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	134	45	I	S	aTc/aGc	6.61	1	0	benign	0.18	neutral	0.41	neutral	4.28	deleterious	-4.33	deleterious	-4.58	high_impact	4.98	0.84	neutral	0.38	neutral	2.61	20.30	deleterious	0.03	0.35	0.88	disease	0.85	disease	0.62	disease	0.67	disease	3	0.51	neutral	0.62	deleterious	-2	neutral	0.57	deleterious	-0.12	medium_impact	0.14	medium_impact	3.33	high_impact	0.29	0.8	55.53	8.5	0.67	P	0.98	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8932	8932	C	G	MI.861	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	406	136	P	A	Ccc/Gcc	-12.6	0	0	probably_damaging	1	neutral	0.53	neutral	4.48	neutral	-0.99	deleterious	-4.96	neutral_impact	0.74	0.89	neutral	0.78	neutral	1.90	15.59	deleterious	0.34	0.65	0.57	disease	0.24	neutral	0.32	neutral	0.55	disease	1	1	deleterious	0.27	neutral	-2	neutral	0.71	deleterious	-3.6	low_impact	0.32	medium_impact	-0.46	medium_impact	0.77	0.9	18.14	17.08	0.38	N	0.56	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14880	14880	T	A	MI.8610	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	134	45	I	N	aTc/aAc	6.61	1	0	benign	0.38	neutral	0.32	neutral	4.26	deleterious	-5.23	deleterious	-5.38	high_impact	4.98	0.83	neutral	0.36	neutral	4.09	23.70	deleterious	0.07	0.35	0.93	disease	0.86	disease	0.62	disease	0.66	disease	3	0.62	neutral	0.47	deleterious	-2	neutral	0.66	deleterious	-0.53	medium_impact	0.05	medium_impact	3.33	high_impact	0.46	0.8	55.53	8.5	0.65	P	0.99	polymorphism	1	0.18	.	.	.	.	.	MNGIE fibroblasts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14881	14881	C	G	MI.8611	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	135	45	I	M	atC/atG	4.54	1	0	possibly_damaging	0.62	neutral	0.31	neutral	4.29	deleterious	-3.83	neutral	-2.21	medium_impact	3.23	0.84	neutral	0.35	neutral	1.54	13.53	neutral	0.16	0.45	0.57	disease	0.73	disease	0.56	disease	0.5	disease	0	0.72	neutral	0.35	neutral	0	NA	0.62	deleterious	-0.93	medium_impact	0.03	medium_impact	1.74	medium_impact	0.66	0.8	55.53	8.5	0.48	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14881	14881	C	A	MI.8612	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	135	45	I	M	atC/atA	4.54	1	0	possibly_damaging	0.62	neutral	0.31	neutral	4.29	deleterious	-3.83	neutral	-2.21	medium_impact	3.23	0.84	neutral	0.35	neutral	1.96	15.97	deleterious	0.16	0.45	0.57	disease	0.73	disease	0.56	disease	0.5	disease	0	0.72	neutral	0.35	neutral	0	NA	0.62	deleterious	-0.93	medium_impact	0.03	medium_impact	1.74	medium_impact	0.66	0.8	55.53	8.5	0.48	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14882	14882	A	G	MI.8613	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	136	46	T	A	Acc/Gcc	-2.57	0	0	benign	0.03	neutral	0.29	neutral	4.74	neutral	0.99	neutral	-0.3	neutral_impact	-0.4	0.93	neutral	0.88	neutral	0.35	6.15	deleterious	0.31	0.45	0.36	neutral	0.25	neutral	0.33	neutral	0.43	neutral	1	0.69	neutral	0.63	deleterious	-6	neutral	0.13	neutral	0.68	medium_impact	0.01	medium_impact	-1.56	low_impact	0.35	0.8	25	38.64	0.38	N	0.18	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14882	14882	A	C	MI.8614	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	136	46	T	P	Acc/Ccc	-2.57	0	0	benign	0.38	neutral	0.08	neutral	4.65	neutral	-2.05	neutral	-1.88	medium_impact	2.63	0.84	neutral	0.45	neutral	2.94	22.00	deleterious	0.05	0.35	0.7	disease	0.83	disease	0.63	disease	0.76	disease	5	0.91	neutral	0.35	neutral	-3	neutral	0.53	deleterious	-0.53	medium_impact	-0.35	medium_impact	1.19	medium_impact	0.40	0.8	25	38.64	0.31	N	0.77	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14882	14882	A	T	MI.8615	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	136	46	T	S	Acc/Tcc	-2.57	0	0	benign	0.1	neutral	0.28	neutral	4.69	neutral	0.06	neutral	-0.99	low_impact	0.94	0.9	neutral	0.71	neutral	1.41	12.82	neutral	0.45	0.55	0.5	disease	0.35	neutral	0.48	neutral	0.21	neutral	6	0.68	neutral	0.59	deleterious	-6	neutral	0.20	neutral	0.16	medium_impact	0	medium_impact	-0.34	medium_impact	0.54	0.8	25	38.64	0.41	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14883	14883	C	G	MI.8616	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	137	46	T	S	aCc/aGc	-6.7	0	0	benign	0.1	neutral	0.28	neutral	4.69	neutral	0.06	neutral	-0.99	low_impact	0.94	0.9	neutral	0.71	neutral	1.61	13.90	neutral	0.45	0.55	0.5	disease	0.35	neutral	0.48	neutral	0.21	neutral	6	0.68	neutral	0.59	deleterious	-6	neutral	0.20	neutral	0.16	medium_impact	0	medium_impact	-0.34	medium_impact	0.54	0.8	25	38.64	0.39	N	0.44	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14883	14883	C	T	MI.8617	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	137	46	T	I	aCc/aTc	-6.7	0	0	benign	0	neutral	0.75	neutral	4.97	neutral	2.8	neutral	1.94	neutral_impact	-1.43	0.95	neutral	0.97	neutral	1.57	13.68	neutral	0.17	0.45	0.14	neutral	0.3	neutral	0.3	neutral	0.43	neutral	1	0.25	neutral	0.88	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.48	medium_impact	-2.49	low_impact	0.63	0.8	25	38.64	0.28	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14883	14883	C	A	MI.8618	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	137	46	T	N	aCc/aAc	-6.7	0	0	benign	0.38	neutral	0.11	neutral	4.65	neutral	-1.75	neutral	-1.85	medium_impact	2.63	0.83	neutral	0.63	neutral	1.94	15.86	deleterious	0.31	0.45	0.67	disease	0.64	disease	0.51	disease	0.54	disease	1	0.87	neutral	0.37	neutral	-3	neutral	0.45	deleterious	-0.53	medium_impact	-0.27	medium_impact	1.19	medium_impact	0.53	0.8	25	38.64	0.34	N	0.57	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14885	14885	A	T	MI.8619	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	139	47	T	S	Aca/Tca	-9.22	0	0	probably_damaging	0.98	neutral	0.58	neutral	3.86	neutral	-2.26	deleterious	-3.17	medium_impact	2.32	0.98	neutral	0.44	neutral	1.47	13.18	neutral	0.35	0.5	0.55	disease	0.74	disease	0.54	disease	0.46	neutral	1	0.97	neutral	0.3	neutral	1	deleterious	0.78	deleterious	-2.31	low_impact	0.3	medium_impact	0.91	medium_impact	0.56	0.8	58.68	8.72	0.28	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8932	8932	C	A	MI.862	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	406	136	P	T	Ccc/Acc	-12.6	0	0	probably_damaging	1	neutral	0.4	neutral	4.36	neutral	-2.75	deleterious	-5.02	medium_impact	2.88	0.88	neutral	0.64	neutral	2.62	20.30	deleterious	0.29	0.65	0.72	disease	0.42	neutral	0.33	neutral	0.64	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.75	deleterious	-3.6	low_impact	0.19	medium_impact	1.37	medium_impact	0.80	0.9	18.14	17.08	0.41	N	0.68	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14885	14885	A	G	MI.8620	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	139	47	T	A	Aca/Gca	-9.22	0	0	probably_damaging	0.98	neutral	0.54	neutral	3.6	deleterious	-4.54	deleterious	-3.99	high_impact	4.78	0.95	neutral	0.11	damaging	1.55	13.56	neutral	0.18	0.45	0.59	disease	0.69	disease	0.7	disease	0.66	disease	3	0.97	neutral	0.28	neutral	2	deleterious	0.77	deleterious	-2.31	low_impact	0.26	medium_impact	3.15	high_impact	0.33	0.8	58.68	8.72	0.59	P	0.59	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14885	14885	A	C	MI.8621	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	139	47	T	P	Aca/Cca	-9.22	0	0	probably_damaging	1	neutral	0.14	neutral	3.53	deleterious	-6.83	deleterious	-4.8	high_impact	5.47	0.95	neutral	0.06	damaging	3.10	22.50	deleterious	0.04	0.35	0.85	disease	0.87	disease	0.81	disease	0.67	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.21	medium_impact	3.77	high_impact	0.32	0.8	58.68	8.72	0.71	P	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14886	14886	C	T	MI.8622	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	140	47	T	M	aCa/aTa	6.84	1	0	probably_damaging	1	neutral	0.3	neutral	3.53	deleterious	-7.98	deleterious	-4.8	high_impact	5.47	0.94	neutral	0.1	damaging	3.87	23.50	deleterious	0.08	0.35	0.88	disease	0.87	disease	0.73	disease	0.62	disease	2	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.02	medium_impact	3.77	high_impact	0.55	0.8	58.68	8.72	0.77	P	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14886	14886	C	A	MI.8623	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	140	47	T	K	aCa/aAa	6.84	1	0	probably_damaging	1	neutral	0.2	neutral	3.54	deleterious	-6.78	deleterious	-4.8	high_impact	5.12	0.94	neutral	0.07	damaging	4.26	23.90	deleterious	0.06	0.35	0.81	disease	0.91	disease	0.79	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.1	medium_impact	3.46	high_impact	0.34	0.8	58.68	8.72	0.77	P	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14888	14888	G	C	MI.8624	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	142	48	G	R	Gga/Cga	-2.34	0	0	probably_damaging	1	neutral	0.35	neutral	1.7	deleterious	-12.38	deleterious	-6.49	high_impact	5.59	0.79	neutral	0.03	damaging	3.81	23.40	deleterious	0.02	0.35	0.94	disease	0.9	disease	0.81	disease	0.64	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	0.08	medium_impact	3.88	high_impact	0.54	0.8	58.68	8.78	0.59	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14888	14888	G	T	MI.8625	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	142	48	G	W	Gga/Tga	-2.34	0	0	probably_damaging	1	neutral	0.18	neutral	1.7	deleterious	-14.22	deleterious	-6.49	high_impact	5.59	0.86	neutral	0.05	damaging	4.28	24.00	deleterious	0.03	0.35	0.99	disease	0.9	disease	0.77	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.88	high_impact	0.11	0.8	58.68	8.78	0.53	N	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14889	14889	G	C	MI.8626	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	143	48	G	A	gGa/gCa	5.92	1	0	probably_damaging	1	neutral	0.51	neutral	1.73	deleterious	-10.66	deleterious	-4.86	high_impact	5.59	0.86	neutral	0.07	damaging	2.82	21.40	deleterious	0.04	0.35	0.8	disease	0.67	disease	0.7	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.23	medium_impact	3.88	high_impact	0.39	0.8	58.68	8.78	0.66	P	0.83	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14889	14889	G	T	MI.8627	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	143	48	G	V	gGa/gTa	5.92	1	0	probably_damaging	1	neutral	0.51	neutral	1.71	deleterious	-12.31	deleterious	-7.3	high_impact	5.59	0.81	neutral	0.06	damaging	3.62	23.20	deleterious	0.02	0.35	0.93	disease	0.88	disease	0.73	disease	0.61	disease	2	1	deleterious	0.26	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.23	medium_impact	3.88	high_impact	0.17	0.8	58.68	8.78	0.64	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14889	14889	G	A	MI.8628	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	143	48	G	E	gGa/gAa	5.92	1	0	probably_damaging	1	neutral	0.27	neutral	1.71	deleterious	-11.98	deleterious	-6.49	high_impact	5.25	0.72	neutral	0.04	damaging	3.76	23.30	deleterious	0.02	0.35	0.92	disease	0.87	disease	0.81	disease	0.64	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.01	medium_impact	3.57	high_impact	0.16	0.8	58.68	8.78	0.67	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14891	14891	C	A	MI.8629	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	145	49	L	M	Cta/Ata	-12.2	0	0	probably_damaging	1	neutral	0.22	neutral	4.4	neutral	-2.22	neutral	-1.53	high_impact	4.05	0.94	neutral	0.12	damaging	3.39	23.00	deleterious	0.18	0.45	0.63	disease	0.62	disease	0.49	neutral	0.48	neutral	0	1	deleterious	0.11	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	-0.08	medium_impact	2.48	high_impact	0.62	0.8	57.89	8.64	0.39	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8932	8932	C	T	MI.863	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	406	136	P	S	Ccc/Tcc	-12.6	0	0	probably_damaging	1	neutral	0.41	neutral	4.35	neutral	-2.85	deleterious	-5.13	medium_impact	2.54	0.89	neutral	0.73	neutral	2.86	21.70	deleterious	0.38	0.65	0.64	disease	0.44	neutral	0.5	neutral	0.61	disease	2	1	deleterious	0.21	neutral	1	deleterious	0.74	deleterious	-3.6	low_impact	0.2	medium_impact	1.08	medium_impact	0.50	0.9	18.14	17.08	0.46	N	0.13	polymorphism	1	0.08	rs878853013	Likely_benign	not_provided	237030	MedGen:CN517202	.	.	CPD	5.48	C8932T	Prostate Cancer / Neuromuscular disorder	+	-	Reported	3	N	P	N,P	damaging
chrM	14891	14891	C	G	MI.8630	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	145	49	L	V	Cta/Gta	-12.2	0	0	probably_damaging	0.96	neutral	0.5	neutral	4.55	neutral	-0.29	neutral	-2.15	medium_impact	2.82	0.96	neutral	0.12	damaging	1.51	13.38	neutral	0.2	0.45	0.18	neutral	0.61	disease	0.36	neutral	0.34	neutral	3	0.96	neutral	0.27	neutral	1	deleterious	0.70	deleterious	-2.02	low_impact	0.22	medium_impact	1.37	medium_impact	0.50	0.8	57.89	8.64	0.27	N	0.91	polymorphism	1	0.02	rs386419981	Likely_pathogenic	Familial_cancer_of_breast	153593	MedGen:C0346153,OMIM:114480,Orphanet:ORPHA227535,SNOMED_CT:254843006	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	14892	14892	T	C	MI.8631	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	146	49	L	P	cTa/cCa	-1.19	0	0	probably_damaging	1	neutral	0.2	neutral	4.34	deleterious	-4.34	deleterious	-5.52	high_impact	4.91	0.94	neutral	0.06	damaging	3.81	23.40	deleterious	0.03	0.35	0.87	disease	0.82	disease	0.71	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.1	medium_impact	3.26	high_impact	0.27	0.8	57.89	8.64	0.65	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	COSM1155575	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14892	14892	T	A	MI.8632	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	146	49	L	Q	cTa/cAa	-1.19	0	0	probably_damaging	1	neutral	0.3	neutral	4.34	deleterious	-4.05	deleterious	-4.77	high_impact	5.25	0.94	neutral	0.08	damaging	4.01	23.60	deleterious	0.04	0.35	0.86	disease	0.81	disease	0.59	disease	0.62	disease	2	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.02	medium_impact	3.57	high_impact	0.18	0.8	57.89	8.64	0.65	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14892	14892	T	G	MI.8633	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	146	49	L	R	cTa/cGa	-1.19	0	0	probably_damaging	1	neutral	0.34	neutral	4.35	deleterious	-3.88	deleterious	-4.78	high_impact	4.91	0.94	neutral	0.06	damaging	3.92	23.50	deleterious	0.03	0.35	0.85	disease	0.89	disease	0.71	disease	0.64	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.07	medium_impact	3.26	high_impact	0.12	0.8	57.89	8.64	0.71	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14894	14894	T	C	MI.8634	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	148	50	F	L	Ttc/Ctc	-1.65	0	0	probably_damaging	0.98	neutral	1	neutral	4.69	neutral	0.44	deleterious	-3.94	medium_impact	2.08	0.95	neutral	0.49	neutral	2.04	16.47	deleterious	0.12	0.4	0.25	neutral	0.71	disease	0.49	neutral	0.16	neutral	7	0.98	neutral	0.51	deleterious	1	deleterious	0.71	deleterious	-2.31	low_impact	1.85	high_impact	0.7	medium_impact	0.40	0.8	55	7.81	0.22	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14894	14894	T	G	MI.8635	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	148	50	F	V	Ttc/Gtc	-1.65	0	0	probably_damaging	0.99	neutral	0.4	neutral	4.55	neutral	-0.76	deleterious	-4.94	high_impact	3.7	0.95	neutral	0.5	neutral	3.59	23.20	deleterious	0.1	0.4	0.53	disease	0.87	disease	0.63	disease	0.68	disease	4	0.99	deleterious	0.21	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.13	medium_impact	2.17	high_impact	0.21	0.8	55	7.81	0.39	N	0.90	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14894	14894	T	A	MI.8636	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	148	50	F	I	Ttc/Atc	-1.65	0	0	probably_damaging	0.98	neutral	0.56	neutral	4.52	neutral	-0.83	deleterious	-4.13	high_impact	3.96	0.94	neutral	0.48	neutral	2.63	20.40	deleterious	0.12	0.4	0.52	disease	0.84	disease	0.61	disease	0.66	disease	3	0.98	deleterious	0.29	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0.28	medium_impact	2.4	high_impact	0.28	0.8	55	7.81	0.33	N	0.80	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14895	14895	T	C	MI.8637	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	149	50	F	S	tTc/tCc	1.33	0.92	0	probably_damaging	1	neutral	0.36	neutral	4.42	neutral	-2.62	deleterious	-5.94	high_impact	4.14	0.94	neutral	0.44	neutral	3.86	23.50	deleterious	0.04	0.35	0.75	disease	0.85	disease	0.66	disease	0.68	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.09	medium_impact	2.57	high_impact	0.17	0.8	55	7.81	0.46	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14895	14895	T	G	MI.8638	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	149	50	F	C	tTc/tGc	1.33	0.92	0	probably_damaging	1	neutral	0.1	neutral	4.4	deleterious	-3.93	deleterious	-5.85	high_impact	5.38	0.96	neutral	0.43	neutral	3.95	23.60	deleterious	0.05	0.35	0.87	disease	0.86	disease	0.68	disease	0.64	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.3	medium_impact	3.69	high_impact	0.13	0.8	55	7.81	0.66	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14895	14895	T	A	MI.8639	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	149	50	F	Y	tTc/tAc	1.33	0.92	0	probably_damaging	0.98	neutral	0.86	neutral	4.41	neutral	-2.92	neutral	-2.25	high_impact	5.38	0.95	neutral	0.45	neutral	2.53	19.66	deleterious	0.13	0.4	0.67	disease	0.78	disease	0.66	disease	0.67	disease	3	0.97	neutral	0.44	neutral	2	deleterious	0.79	deleterious	-2.31	low_impact	0.65	medium_impact	3.69	high_impact	0.39	0.8	55	7.81	0.63	P	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8933	8933	C	T	MI.864	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	407	136	P	L	cCc/cTc	-0.33	0	0	probably_damaging	1	neutral	0.84	neutral	4.45	neutral	-1.44	deleterious	-5.66	neutral_impact	0.6	0.89	neutral	0.91	neutral	2.18	17.40	deleterious	0.4	0.65	0.7	disease	0.31	neutral	0.31	neutral	0.62	disease	2	1	deleterious	0.42	neutral	-2	neutral	0.73	deleterious	-3.6	low_impact	0.7	medium_impact	-0.58	medium_impact	0.77	0.9	18.14	17.08	0.31	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14896	14896	C	A	MI.8640	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	150	50	F	L	ttC/ttA	7.3	0.99	0	probably_damaging	0.98	neutral	1	neutral	4.69	neutral	0.44	deleterious	-3.94	medium_impact	2.08	0.95	neutral	0.49	neutral	2.74	21.00	deleterious	0.12	0.4	0.25	neutral	0.71	disease	0.49	neutral	0.16	neutral	7	0.98	neutral	0.51	deleterious	1	deleterious	0.71	deleterious	-2.31	low_impact	1.85	high_impact	0.7	medium_impact	0.40	0.8	55	7.81	0.48	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14896	14896	C	G	MI.8641	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	150	50	F	L	ttC/ttG	7.3	0.99	0	probably_damaging	0.98	neutral	1	neutral	4.69	neutral	0.44	deleterious	-3.94	medium_impact	2.08	0.95	neutral	0.49	neutral	2.42	18.94	deleterious	0.12	0.4	0.25	neutral	0.71	disease	0.49	neutral	0.16	neutral	7	0.98	neutral	0.51	deleterious	1	deleterious	0.71	deleterious	-2.31	low_impact	1.85	high_impact	0.7	medium_impact	0.40	0.8	55	7.81	0.47	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14897	14897	C	A	MI.8642	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	151	51	L	M	Cta/Ata	-2.57	0	0	probably_damaging	1	neutral	0.24	neutral	3.23	deleterious	-5.34	neutral	-1.58	high_impact	4.24	0.94	neutral	0.1	damaging	3.40	23.00	deleterious	0.17	0.45	0.43	neutral	0.62	disease	0.61	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	-0.05	medium_impact	2.66	high_impact	0.33	0.8	59.21	8.69	0.41	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14897	14897	C	G	MI.8643	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	151	51	L	V	Cta/Gta	-2.57	0	0	probably_damaging	0.96	neutral	0.45	neutral	3.27	deleterious	-4.66	neutral	-2.43	high_impact	4.04	0.96	neutral	0.11	damaging	1.52	13.40	neutral	0.17	0.45	0.66	disease	0.64	disease	0.69	disease	0.66	disease	3	0.96	neutral	0.25	neutral	2	deleterious	0.79	deleterious	-2.02	low_impact	0.18	medium_impact	2.48	high_impact	0.34	0.8	59.21	8.69	0.33	N	0.91	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14898	14898	T	A	MI.8644	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	152	51	L	Q	cTa/cAa	-0.5	0	0	probably_damaging	1	neutral	0.28	neutral	3.17	deleterious	-9.07	deleterious	-4.86	high_impact	5.56	0.94	neutral	0.07	damaging	3.82	23.40	deleterious	0.05	0.35	0.93	disease	0.81	disease	0.69	disease	0.65	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0	medium_impact	3.86	high_impact	0.24	0.8	59.21	8.69	0.63	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14898	14898	T	C	MI.8645	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	152	51	L	P	cTa/cCa	-0.5	0	0	probably_damaging	1	neutral	0.17	neutral	3.17	deleterious	-8.92	deleterious	-5.69	high_impact	4.41	0.94	neutral	0.05	damaging	3.74	23.30	deleterious	0.03	0.35	0.95	disease	0.8	disease	0.77	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.15	medium_impact	2.81	high_impact	0.23	0.8	59.21	8.69	0.51	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14898	14898	T	G	MI.8646	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	152	51	L	R	cTa/cGa	-0.5	0	0	probably_damaging	1	neutral	0.29	neutral	3.17	deleterious	-8.98	deleterious	-4.87	high_impact	5.56	0.94	neutral	0.06	damaging	3.92	23.50	deleterious	0.03	0.35	0.94	disease	0.89	disease	0.78	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.01	medium_impact	3.86	high_impact	0.15	0.8	59.21	8.69	0.71	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14900	14900	G	T	MI.8647	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	154	52	A	S	Gcc/Tcc	-0.04	0.94	0	probably_damaging	1	neutral	0.45	neutral	4.38	neutral	-0.62	neutral	-2.16	medium_impact	2.2	0.97	neutral	0.52	neutral	3.17	22.70	deleterious	0.19	0.45	0.76	disease	0.76	disease	0.45	neutral	0.23	neutral	5	1	deleterious	0.23	neutral	1	deleterious	0.85	deleterious	-3.53	low_impact	0.18	medium_impact	0.8	medium_impact	0.34	0.8	57.37	8.4	0.35	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14900	14900	G	C	MI.8648	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	154	52	A	P	Gcc/Ccc	-0.04	0.94	0	probably_damaging	1	neutral	0.19	neutral	4.31	deleterious	-3.99	deleterious	-3.92	high_impact	5.39	0.94	neutral	0.26	damaging	3.56	23.10	deleterious	0.04	0.35	0.9	disease	0.86	disease	0.76	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.12	medium_impact	3.7	high_impact	0.51	0.8	57.37	8.4	0.71	P	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14900	14900	G	A	MI.8649	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	154	52	A	T	Gcc/Acc	-0.04	0.94	0	probably_damaging	1	neutral	0.48	neutral	4.42	neutral	-2.16	deleterious	-3.03	medium_impact	2.84	0.91	neutral	0.47	neutral	3.82	23.40	deleterious	0.12	0.4	0.81	disease	0.79	disease	0.49	neutral	0.46	neutral	1	1	deleterious	0.24	neutral	1	deleterious	0.85	deleterious	-3.53	low_impact	0.2	medium_impact	1.39	medium_impact	0.52	0.8	57.37	8.4	0.36	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8933	8933	C	A	MI.865	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	407	136	P	H	cCc/cAc	-0.33	0	0	probably_damaging	1	neutral	0.54	neutral	4.31	deleterious	-4.57	deleterious	-5.96	high_impact	3.58	0.82	neutral	0.44	neutral	4.10	23.70	deleterious	0.24	0.65	0.83	disease	0.6	disease	0.61	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.6	low_impact	0.33	medium_impact	1.97	medium_impact	0.72	0.9	18.14	17.08	0.27	N	0.95	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14901	14901	C	A	MI.8650	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	155	52	A	D	gCc/gAc	5.92	1	0	probably_damaging	1	neutral	0.22	neutral	4.31	deleterious	-4.11	deleterious	-4.64	high_impact	5.39	0.92	neutral	0.37	neutral	4.37	24.10	deleterious	0.04	0.35	0.92	disease	0.91	disease	0.74	disease	0.62	disease	2	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.08	medium_impact	3.7	high_impact	0.24	0.8	57.37	8.4	0.79	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14901	14901	C	T	MI.8651	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	155	52	A	V	gCc/gTc	5.92	1	0	probably_damaging	1	neutral	0.54	neutral	4.45	neutral	-1.4	deleterious	-3.19	high_impact	3.85	0.95	neutral	0.5	neutral	3.96	23.60	deleterious	0.09	0.35	0.86	disease	0.82	disease	0.66	disease	0.63	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.26	medium_impact	2.3	high_impact	0.61	0.8	57.37	8.4	0.6	P	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14901	14901	C	G	MI.8652	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	155	52	A	G	gCc/gGc	5.92	1	0	probably_damaging	0.99	neutral	0.43	neutral	4.35	deleterious	-3.4	deleterious	-3.12	high_impact	4.58	0.93	neutral	0.5	neutral	2.15	17.19	deleterious	0.16	0.45	0.82	disease	0.77	disease	0.64	disease	0.65	disease	3	0.99	deleterious	0.22	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	0.16	medium_impact	2.97	high_impact	0.58	0.8	57.37	8.4	0.66	P	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14903	14903	A	G	MI.8653	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	157	53	M	V	Atg/Gtg	-9.22	0	0	probably_damaging	0.91	neutral	0.5	neutral	4.43	neutral	-1.65	deleterious	-3.11	high_impact	3.6	0.87	neutral	0.1	damaging	0.85	9.76	deleterious	0.18	0.45	0.45	neutral	0.76	disease	0.75	disease	0.69	disease	4	0.9	neutral	0.3	neutral	2	deleterious	0.74	deleterious	-1.67	low_impact	0.22	medium_impact	2.08	high_impact	0.22	0.8	59.21	8.84	0.31	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14903	14903	A	C	MI.8654	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	157	53	M	L	Atg/Ctg	-9.22	0	0	possibly_damaging	0.86	neutral	0.68	neutral	4.53	neutral	-0.52	neutral	-2.35	medium_impact	3.23	0.87	neutral	0.08	damaging	1.44	13.01	neutral	0.17	0.45	0.41	neutral	0.76	disease	0.66	disease	0.66	disease	3	0.84	neutral	0.41	neutral	0	NA	0.68	deleterious	-1.47	low_impact	0.4	medium_impact	1.74	medium_impact	0.29	0.8	59.21	8.84	0.21	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14903	14903	A	T	MI.8655	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	157	53	M	L	Atg/Ttg	-9.22	0	0	possibly_damaging	0.86	neutral	0.68	neutral	4.53	neutral	-0.52	neutral	-2.35	medium_impact	3.23	0.87	neutral	0.08	damaging	1.50	13.32	neutral	0.17	0.45	0.41	neutral	0.76	disease	0.66	disease	0.66	disease	3	0.84	neutral	0.41	neutral	0	NA	0.68	deleterious	-1.47	low_impact	0.4	medium_impact	1.74	medium_impact	0.29	0.8	59.21	8.84	0.21	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14904	14904	T	A	MI.8656	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	158	53	M	K	aTg/aAg	4.54	0.99	0	probably_damaging	1	neutral	0.29	neutral	4.33	deleterious	-3.97	deleterious	-4.73	high_impact	5.44	0.85	neutral	0.08	damaging	2.40	18.85	deleterious	0.04	0.35	0.73	disease	0.85	disease	0.8	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.01	medium_impact	3.75	high_impact	0.14	0.8	59.21	8.84	0.77	P	0.99	disease_causing	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14904	14904	T	C	MI.8657	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	158	53	M	T	aTg/aCg	4.54	0.99	0	probably_damaging	1	neutral	0.4	neutral	4.38	neutral	-2.65	deleterious	-4.58	high_impact	3.85	0.85	neutral	0.11	damaging	2.62	20.30	deleterious	0.09	0.35	0.58	disease	0.79	disease	0.72	disease	0.42	neutral	2	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.13	medium_impact	2.3	high_impact	0.11	0.8	59.21	8.84	0.49	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	COSM6716253	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14905	14905	G	T	MI.8658	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	159	53	M	I	atG/atT	2.71	0.99	0.1	probably_damaging	0.94	neutral	0.4	neutral	4.42	neutral	-1.88	deleterious	-3.13	medium_impact	3.25	0.85	neutral	0.09	damaging	1.72	14.49	neutral	0.13	0.4	0.48	neutral	0.79	disease	0.71	disease	0.67	disease	3	0.94	neutral	0.23	neutral	1	deleterious	0.77	deleterious	-1.85	low_impact	0.13	medium_impact	1.76	medium_impact	0.29	0.8	59.21	8.84	0.36	N	0.95	disease_causing	1	0.02	rs193302983	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	14905	14905	G	C	MI.8659	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	159	53	M	I	atG/atC	2.71	0.99	0.1	probably_damaging	0.94	neutral	0.4	neutral	4.42	neutral	-1.88	deleterious	-3.13	medium_impact	3.25	0.85	neutral	0.09	damaging	1.61	13.88	neutral	0.13	0.4	0.48	neutral	0.79	disease	0.71	disease	0.67	disease	3	0.94	neutral	0.23	neutral	1	deleterious	0.77	deleterious	-1.85	low_impact	0.13	medium_impact	1.76	medium_impact	0.29	0.8	59.21	8.84	0.35	N	0.95	disease_causing	1	0.02	rs193302983	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	8933	8933	C	G	MI.866	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	407	136	P	R	cCc/cGc	-0.33	0	0	probably_damaging	1	neutral	0.35	neutral	4.32	deleterious	-3.95	deleterious	-5.95	medium_impact	3.23	0.82	neutral	0.42	neutral	3.59	23.20	deleterious	0.2	0.65	0.67	disease	0.69	disease	0.68	disease	0.69	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	0.14	medium_impact	1.67	medium_impact	0.68	0.9	18.14	17.08	0.29	N	0.96	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14906	14906	C	G	MI.8660	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	160	54	H	D	Cac/Gac	-0.04	0.76	0	probably_damaging	0.99	neutral	0.21	neutral	4.5	neutral	-1.84	deleterious	-7.37	high_impact	5.5	0.72	neutral	0.36	neutral	2.17	17.31	deleterious	0.04	0.35	0.75	disease	0.85	disease	0.84	disease	0.73	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	-0.09	medium_impact	3.8	high_impact	0.27	0.8	58.42	8.9	0.66	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14906	14906	C	T	MI.8661	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	160	54	H	Y	Cac/Tac	-0.04	0.76	0	probably_damaging	0.98	neutral	1	neutral	4.73	deleterious	-3.73	deleterious	-4.91	medium_impact	3.4	0.84	neutral	0.39	neutral	1.84	15.24	deleterious	0.09	0.35	0.45	neutral	0.85	disease	0.7	disease	0.69	disease	4	0.98	deleterious	0.51	deleterious	1	deleterious	0.80	deleterious	-2.31	low_impact	1.85	high_impact	1.89	medium_impact	0.27	0.8	58.42	8.9	0.24	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14906	14906	C	A	MI.8662	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	160	54	H	N	Cac/Aac	-0.04	0.76	0	probably_damaging	0.99	neutral	0.3	neutral	4.54	neutral	-1.86	deleterious	-5.73	high_impact	3.82	0.83	neutral	0.43	neutral	2.02	16.31	deleterious	0.18	0.45	0.72	disease	0.84	disease	0.79	disease	0.7	disease	4	0.99	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.02	medium_impact	2.28	high_impact	0.26	0.8	58.42	8.9	0.41	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14907	14907	A	C	MI.8663	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	161	54	H	P	cAc/cCc	5.46	1	0	probably_damaging	1	neutral	0.2	neutral	4.48	deleterious	-3.24	deleterious	-8.19	high_impact	4.95	0.84	neutral	0.28	damaging	1.56	13.64	neutral	0.02	0.35	0.84	disease	0.86	disease	0.86	disease	0.7	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.1	medium_impact	3.3	high_impact	0.16	0.8	58.42	8.9	0.73	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14907	14907	A	T	MI.8664	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	161	54	H	L	cAc/cTc	5.46	1	0	probably_damaging	0.98	neutral	0.68	neutral	4.57	neutral	-2.61	deleterious	-9.01	high_impact	4.53	0.84	neutral	0.38	neutral	2.01	16.25	deleterious	0.03	0.35	0.62	disease	0.9	disease	0.78	disease	0.72	disease	4	0.98	deleterious	0.35	neutral	2	deleterious	0.83	deleterious	-2.31	low_impact	0.4	medium_impact	2.92	high_impact	0.15	0.8	58.42	8.9	0.63	P	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14907	14907	A	G	MI.8665	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	161	54	H	R	cAc/cGc	5.46	1	0	probably_damaging	0.98	neutral	0.32	neutral	4.52	neutral	-0.1	deleterious	-6.55	high_impact	4.46	0.84	neutral	0.34	neutral	1.15	11.48	neutral	0.07	0.35	0.5	disease	0.88	disease	0.75	disease	0.7	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-2.31	low_impact	0.05	medium_impact	2.86	high_impact	0.33	0.8	58.42	8.9	0.58	P	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14908	14908	C	A	MI.8666	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	162	54	H	Q	caC/caA	6.84	1	0	probably_damaging	0.99	neutral	0.27	neutral	4.51	neutral	-1.56	deleterious	-6.55	high_impact	4.4	0.84	neutral	0.36	neutral	1.96	15.99	deleterious	0.1	0.4	0.69	disease	0.81	disease	0.73	disease	0.69	disease	4	0.99	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	-0.01	medium_impact	2.8	high_impact	0.38	0.8	58.42	8.9	0.61	P	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14908	14908	C	G	MI.8667	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	162	54	H	Q	caC/caG	6.84	1	0	probably_damaging	0.99	neutral	0.27	neutral	4.51	neutral	-1.56	deleterious	-6.55	high_impact	4.4	0.84	neutral	0.36	neutral	1.70	14.41	neutral	0.1	0.4	0.69	disease	0.81	disease	0.73	disease	0.69	disease	4	0.99	deleterious	0.14	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	-0.01	medium_impact	2.8	high_impact	0.38	0.8	58.42	8.9	0.61	P	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14909	14909	T	G	MI.8668	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	163	55	Y	D	Tac/Gac	-0.96	0.02	0	probably_damaging	1	neutral	0.21	neutral	2.74	deleterious	-9.74	deleterious	-8.18	high_impact	5.22	0.83	neutral	0.07	damaging	3.71	23.30	deleterious	0.03	0.35	0.96	disease	0.84	disease	0.84	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.09	medium_impact	3.55	high_impact	0.15	0.8	56.84	8.8	0.58	P	1.00	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14909	14909	T	A	MI.8669	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	163	55	Y	N	Tac/Aac	-0.96	0.02	0	probably_damaging	1	neutral	0.29	neutral	2.74	deleterious	-8.75	deleterious	-7.37	high_impact	5.57	0.85	neutral	0.09	damaging	3.95	23.60	deleterious	0.06	0.35	0.92	disease	0.81	disease	0.78	disease	0.67	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.01	medium_impact	3.86	high_impact	0.13	0.8	56.84	8.8	0.62	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8935	8935	C	G	MI.867	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	409	137	L	V	Ctt/Gtt	-20	0	0	probably_damaging	0.99	deleterious	0	neutral	3.7	deleterious	-3.32	deleterious	-2.7	high_impact	4.05	0.38	damaging	0.1	damaging	3.50	23.10	deleterious	0.38	0.65	0.59	disease	0.52	disease	0.76	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.78	deleterious	-2.65	low_impact	-1.4	low_impact	2.37	high_impact	0.75	0.9	49.56	8.85	0.42	N	0.87	polymorphism	0.97	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14909	14909	T	C	MI.8670	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	163	55	Y	H	Tac/Cac	-0.96	0.02	0	probably_damaging	1	neutral	0.59	neutral	2.77	deleterious	-6.67	deleterious	-4.1	high_impact	4.88	0.89	neutral	0.08	damaging	3.34	22.90	deleterious	0.11	0.4	0.84	disease	0.75	disease	0.83	disease	0.7	disease	4	1	deleterious	0.3	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.31	medium_impact	3.24	high_impact	0.14	0.8	56.84	8.8	0.68	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14910	14910	A	T	MI.8671	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	164	55	Y	F	tAc/tTc	3.63	1	0	probably_damaging	0.99	neutral	0.71	neutral	2.9	deleterious	-4.62	deleterious	-3.24	medium_impact	3.29	0.91	neutral	0.08	damaging	1.61	13.90	neutral	0.17	0.45	0.51	disease	0.75	disease	0.5	neutral	0.37	neutral	3	0.99	deleterious	0.36	neutral	1	deleterious	0.80	deleterious	-2.59	low_impact	0.43	medium_impact	1.79	medium_impact	0.42	0.8	56.84	8.8	0.41	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14910	14910	A	C	MI.8672	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	164	55	Y	S	tAc/tCc	3.63	1	0	probably_damaging	1	neutral	0.41	neutral	2.75	deleterious	-8.52	deleterious	-7.36	high_impact	5.22	0.88	neutral	0.09	damaging	3.41	23.00	deleterious	0.06	0.35	0.91	disease	0.81	disease	0.77	disease	0.67	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.14	medium_impact	3.55	high_impact	0.12	0.8	56.84	8.8	0.65	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14910	14910	A	G	MI.8673	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	164	55	Y	C	tAc/tGc	3.63	1	0	probably_damaging	1	neutral	0.18	neutral	2.74	deleterious	-10.11	deleterious	-7.36	high_impact	5.22	0.85	neutral	0.05	damaging	3.38	23.00	deleterious	0.05	0.35	0.96	disease	0.83	disease	0.79	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.14	medium_impact	3.55	high_impact	0.17	0.8	56.84	8.8	0.57	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14912	14912	T	A	MI.8674	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	166	56	S	T	Tca/Aca	-2.34	0	0	benign	0	neutral	0.48	neutral	4.81	neutral	2.35	neutral	2.34	neutral_impact	-2.13	0.96	neutral	0.9	neutral	-0.68	0.08	neutral	0.3	0.45	0.16	neutral	0.05	neutral	0.16	neutral	0.21	neutral	6	0.52	neutral	0.74	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.2	medium_impact	-3.13	low_impact	0.57	0.8	20.79	48.85	0.47	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14912	14912	T	C	MI.8675	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	166	56	S	P	Tca/Cca	-2.34	0	0	benign	0.15	neutral	0.19	neutral	4.59	neutral	-1.77	neutral	-1.99	medium_impact	2.58	0.84	neutral	0.44	neutral	2.29	18.11	deleterious	0.05	0.35	0.7	disease	0.82	disease	0.55	disease	0.72	disease	4	0.78	neutral	0.52	deleterious	-3	neutral	0.44	deleterious	-0.03	medium_impact	-0.12	medium_impact	1.15	medium_impact	0.24	0.8	20.79	48.85	0.29	N	0.75	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14912	14912	T	G	MI.8676	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	166	56	S	A	Tca/Gca	-2.34	0	0	benign	0	neutral	0.49	neutral	4.67	neutral	0.77	neutral	-1	low_impact	0.98	0.83	neutral	0.81	neutral	1.74	14.65	neutral	0.32	0.5	0.36	neutral	0.3	neutral	0.28	neutral	0.43	neutral	1	0.51	neutral	0.75	deleterious	-6	neutral	0.16	neutral	2.07	high_impact	0.21	medium_impact	-0.3	medium_impact	0.40	0.8	20.79	48.85	0.38	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14913	14913	C	T	MI.8677	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	167	56	S	L	tCa/tTa	3.63	0.99	0	benign	0.05	neutral	0.6	neutral	4.61	neutral	-0.72	neutral	-2.03	medium_impact	1.97	0.77	neutral	0.58	neutral	2.91	21.90	deleterious	0.06	0.35	0.42	neutral	0.66	disease	0.55	disease	0.66	disease	3	0.34	neutral	0.78	deleterious	-3	neutral	0.24	neutral	0.46	medium_impact	0.32	medium_impact	0.6	medium_impact	0.38	0.8	20.79	48.85	0.41	N	0.72	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14913	14913	C	G	MI.8678	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	167	56	S	W	tCa/tGa	3.63	0.99	0	possibly_damaging	0.67	neutral	0.15	neutral	4.57	deleterious	-4	deleterious	-2.92	medium_impact	3.12	0.85	neutral	0.48	neutral	4.11	23.70	deleterious	0.06	0.35	0.86	disease	0.79	disease	0.66	disease	0.71	disease	4	0.87	neutral	0.24	neutral	0	NA	0.73	deleterious	-1.02	low_impact	-0.19	medium_impact	1.64	medium_impact	0.12	0.8	20.79	48.85	0.45	N	0.87	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14915	14915	C	T	MI.8679	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	169	57	P	S	Cca/Tca	-3.94	0	0	benign	0.02	neutral	0.56	neutral	4.16	deleterious	-4.37	neutral	0.84	neutral_impact	0.24	0.95	neutral	0.98	neutral	0.86	9.81	deleterious	0.19	0.45	0.17	neutral	0.13	neutral	0.26	neutral	0.28	neutral	4	0.41	neutral	0.77	deleterious	-6	neutral	0.10	neutral	0.85	medium_impact	0.28	medium_impact	-0.98	medium_impact	0.10	0.8	20	28.35	0.31	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8935	8935	C	A	MI.868	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	409	137	L	I	Ctt/Att	-20	0	0	probably_damaging	0.99	deleterious	0.04	neutral	3.71	deleterious	-3.21	neutral	-1.8	medium_impact	3.19	0.49	damaging	0.11	damaging	4.20	23.90	deleterious	0.31	0.65	0.62	disease	0.48	neutral	0.61	disease	0.6	disease	2	1	deleterious	0.03	neutral	5	deleterious	0.77	deleterious	-2.65	low_impact	-0.49	medium_impact	1.64	medium_impact	0.72	0.9	49.56	8.85	0.32	N	0.87	polymorphism	0.98	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14915	14915	C	G	MI.8680	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	169	57	P	A	Cca/Gca	-3.94	0	0	benign	0.14	neutral	0.53	neutral	4.19	deleterious	-4.15	neutral	0.99	neutral_impact	-0.39	0.97	neutral	0.94	neutral	0.63	8.35	deleterious	0.15	0.45	0.27	neutral	0.09	neutral	0.22	neutral	0.24	neutral	5	0.37	neutral	0.7	deleterious	-6	neutral	0.23	neutral	0	medium_impact	0.25	medium_impact	-1.55	low_impact	0.58	0.8	20	28.35	0.34	N	0.08	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14915	14915	C	A	MI.8681	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	169	57	P	T	Cca/Aca	-3.94	0	0	benign	0.31	neutral	0.51	neutral	4.06	deleterious	-4.89	neutral	-0.36	medium_impact	2.88	0.92	neutral	0.6	neutral	3.38	22.90	deleterious	0.15	0.45	0.55	disease	0.34	neutral	0.32	neutral	0.59	disease	2	0.4	neutral	0.6	deleterious	-3	neutral	0.38	neutral	-0.41	medium_impact	0.23	medium_impact	1.42	medium_impact	0.47	0.8	20	28.35	0.36	N	0.40	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14916	14916	C	A	MI.8682	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	170	57	P	Q	cCa/cAa	-0.04	0.02	0	possibly_damaging	0.7	neutral	0.27	neutral	4.03	deleterious	-6.8	neutral	-1.06	high_impact	4.37	0.93	neutral	0.53	neutral	3.91	23.50	deleterious	0.09	0.4	0.73	disease	0.48	neutral	0.65	disease	0.68	disease	4	0.79	neutral	0.29	neutral	1	deleterious	0.63	deleterious	-1.07	low_impact	-0.01	medium_impact	2.77	high_impact	0.30	0.8	20	28.35	0.54	P	0.57	polymorphism	1	0.13	rs56787243	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14916	14916	C	G	MI.8683	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	170	57	P	R	cCa/cGa	-0.04	0.02	0	possibly_damaging	0.71	neutral	0.33	neutral	4.03	deleterious	-6.86	neutral	-1.52	high_impact	4.37	0.93	neutral	0.48	neutral	3.35	22.90	deleterious	0.08	0.35	0.71	disease	0.72	disease	0.76	disease	0.72	disease	4	0.76	neutral	0.31	neutral	1	deleterious	0.65	deleterious	-1.09	low_impact	0.06	medium_impact	2.77	high_impact	0.26	0.8	20	28.35	0.5	N	0.75	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14916	14916	C	T	MI.8684	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	170	57	P	L	cCa/cTa	-0.04	0.02	0	possibly_damaging	0.52	neutral	0.63	neutral	4.04	deleterious	-6.21	neutral	-1.98	high_impact	3.82	0.93	neutral	0.53	neutral	4.04	23.70	deleterious	0.12	0.4	0.74	disease	0.58	disease	0.59	disease	0.67	disease	3	0.45	neutral	0.56	deleterious	1	deleterious	0.55	deleterious	-0.76	medium_impact	0.35	medium_impact	2.28	high_impact	0.68	0.85	20	28.35	0.32	N	0.80	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14918	14918	G	T	MI.8685	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	172	58	D	Y	Gac/Tac	-3.94	0	0	probably_damaging	1	neutral	1	neutral	4.46	deleterious	-3.68	deleterious	-6.68	high_impact	4.64	0.91	neutral	0.43	neutral	3.78	23.40	deleterious	0.05	0.35	0.83	disease	0.9	disease	0.66	disease	0.64	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.53	low_impact	1.85	high_impact	3.02	high_impact	0.08	0.8	50.53	7.84	0.43	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14918	14918	G	A	MI.8686	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	172	58	D	N	Gac/Aac	-3.94	0	0	probably_damaging	1	neutral	0.32	neutral	4.55	neutral	-0.88	deleterious	-3.4	low_impact	1.66	0.65	neutral	0.52	neutral	3.76	23.30	deleterious	0.49	0.55	0.25	neutral	0.72	disease	0.29	neutral	0.19	neutral	6	1	deleterious	0.16	neutral	-2	neutral	0.71	deleterious	-3.53	low_impact	0.05	medium_impact	0.31	medium_impact	0.49	0.8	50.53	7.84	0.38	N	0.99	polymorphism	1	0.03	.	.	.	.	.	.	COSM1138285	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14918	14918	G	C	MI.8687	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	172	58	D	H	Gac/Cac	-3.94	0	0	probably_damaging	1	neutral	0.55	neutral	4.5	neutral	-2.07	deleterious	-4.89	medium_impact	2.64	0.9	neutral	0.33	neutral	3.54	23.10	deleterious	0.11	0.4	0.33	neutral	0.8	disease	0.39	neutral	0.41	neutral	2	1	deleterious	0.28	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	0.27	medium_impact	1.2	medium_impact	0.33	0.8	50.53	7.84	0.26	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14919	14919	A	T	MI.8688	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	173	58	D	V	gAc/gTc	4.31	1	0	probably_damaging	1	neutral	0.52	neutral	4.49	deleterious	-4.01	deleterious	-6.87	high_impact	5.19	0.91	neutral	0.48	neutral	3.55	23.10	deleterious	0.04	0.35	0.75	disease	0.89	disease	0.61	disease	0.66	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.24	medium_impact	3.52	high_impact	0.08	0.8	50.53	7.84	0.67	P	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14919	14919	A	C	MI.8689	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	173	58	D	A	gAc/gCc	4.31	1	0	probably_damaging	1	neutral	0.56	neutral	4.54	neutral	-1.73	deleterious	-6.03	high_impact	4.38	0.91	neutral	0.46	neutral	3.18	22.70	deleterious	0.07	0.35	0.55	disease	0.73	disease	0.62	disease	0.64	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.28	medium_impact	2.78	high_impact	0.18	0.8	50.53	7.84	0.51	N	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8935	8935	C	T	MI.869	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	409	137	L	F	Ctt/Ttt	-20	0	0	probably_damaging	1	deleterious	0.04	neutral	3.78	neutral	-2.42	deleterious	-3.6	high_impact	4.25	0.44	damaging	0.1	damaging	4.00	23.60	deleterious	0.38	0.65	0.74	disease	0.55	disease	0.75	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-0.49	medium_impact	2.54	high_impact	0.66	0.9	49.56	8.85	0.39	N	0.97	polymorphism	0.86	0.20	rs28377547	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14919	14919	A	G	MI.8690	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	173	58	D	G	gAc/gGc	4.31	1	0	probably_damaging	1	neutral	0.34	neutral	4.5	neutral	-1.14	deleterious	-5.22	high_impact	3.9	0.9	neutral	0.47	neutral	3.69	23.30	deleterious	0.08	0.35	0.63	disease	0.86	disease	0.62	disease	0.66	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.07	medium_impact	2.35	high_impact	0.20	0.8	50.53	7.84	0.61	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14920	14920	C	G	MI.8691	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	174	58	D	E	gaC/gaG	6.84	1	0	probably_damaging	0.98	neutral	0.31	neutral	4.61	neutral	-1.09	deleterious	-2.95	medium_impact	2.87	0.89	neutral	0.43	neutral	2.00	16.24	deleterious	0.25	0.45	0.32	neutral	0.71	disease	0.44	neutral	0.35	neutral	3	0.98	neutral	0.17	neutral	1	deleterious	0.72	deleterious	-2.31	low_impact	0.03	medium_impact	1.41	medium_impact	0.27	0.8	50.53	7.84	0.61	P	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14920	14920	C	A	MI.8692	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	174	58	D	E	gaC/gaA	6.84	1	0	probably_damaging	0.98	neutral	0.31	neutral	4.61	neutral	-1.09	deleterious	-2.95	medium_impact	2.87	0.89	neutral	0.43	neutral	2.35	18.47	deleterious	0.25	0.45	0.32	neutral	0.71	disease	0.44	neutral	0.35	neutral	3	0.98	neutral	0.17	neutral	1	deleterious	0.72	deleterious	-2.31	low_impact	0.03	medium_impact	1.41	medium_impact	0.27	0.8	50.53	7.84	0.61	P	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14921	14921	G	A	MI.8693	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	175	59	A	T	Gcc/Acc	-0.96	0	0	probably_damaging	1	neutral	0.41	neutral	4.66	neutral	1.42	neutral	1.39	neutral_impact	-2.25	0.95	neutral	0.87	neutral	1.13	11.38	neutral	0.24	0.45	0.15	neutral	0.08	neutral	0.11	neutral	0.3	neutral	4	1	deleterious	0.21	neutral	-2	neutral	0.62	deleterious	-3.53	low_impact	0.14	medium_impact	-3.24	low_impact	0.65	0.8	16.32	12.69	0.45	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	COSM1138287	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14921	14921	G	T	MI.8694	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	175	59	A	S	Gcc/Tcc	-0.96	0	0	probably_damaging	0.99	neutral	0.44	neutral	4.57	neutral	-0.3	neutral	-0.32	neutral_impact	0.28	0.94	neutral	0.64	neutral	1.98	16.08	deleterious	0.29	0.45	0.27	neutral	0.46	neutral	0.41	neutral	0.45	neutral	1	0.99	deleterious	0.23	neutral	-2	neutral	0.71	deleterious	-2.59	low_impact	0.17	medium_impact	-0.94	medium_impact	0.42	0.8	16.32	12.69	0.35	N	0.55	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14921	14921	G	C	MI.8695	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	175	59	A	P	Gcc/Ccc	-0.96	0	0	probably_damaging	1	neutral	0.21	neutral	4.54	neutral	-1.99	neutral	-1.48	low_impact	1.73	0.94	neutral	0.4	neutral	3.54	23.10	deleterious	0.08	0.35	0.6	disease	0.8	disease	0.57	disease	0.71	disease	4	1	deleterious	0.11	neutral	-2	neutral	0.84	deleterious	-3.53	low_impact	-0.09	medium_impact	0.38	medium_impact	0.51	0.8	16.32	12.69	0.36	N	0.75	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14922	14922	C	T	MI.8696	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	176	59	A	V	gCc/gTc	4.54	0.84	0	probably_damaging	1	neutral	0.5	neutral	4.67	neutral	1.03	neutral	1.6	neutral_impact	-0.8	0.95	neutral	0.75	neutral	2.96	22.10	deleterious	0.19	0.45	0.15	neutral	0.45	neutral	0.13	neutral	0.4	neutral	2	0.99	deleterious	0.25	neutral	-2	neutral	0.64	deleterious	-3.53	low_impact	0.22	medium_impact	-1.92	low_impact	0.73	0.85	16.32	12.69	0.37	N	0.43	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14922	14922	C	G	MI.8697	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	176	59	A	G	gCc/gGc	4.54	0.84	0	probably_damaging	0.99	neutral	0.33	neutral	4.55	neutral	-1.44	neutral	-2.2	low_impact	1.18	0.93	neutral	0.61	neutral	2.31	18.25	deleterious	0.26	0.45	0.52	disease	0.55	disease	0.39	neutral	0.45	neutral	1	0.99	deleterious	0.17	neutral	-2	neutral	0.75	deleterious	-2.59	low_impact	0.06	medium_impact	-0.12	medium_impact	0.59	0.8	16.32	12.69	0.43	N	0.64	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14922	14922	C	A	MI.8698	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	176	59	A	D	gCc/gAc	4.54	0.84	0	probably_damaging	1	neutral	0.27	neutral	4.52	neutral	-1.2	neutral	-1.57	low_impact	1.27	0.93	neutral	0.49	neutral	4.26	23.90	deleterious	0.08	0.35	0.63	disease	0.8	disease	0.6	disease	0.71	disease	4	1	deleterious	0.14	neutral	-2	neutral	0.82	deleterious	-3.53	low_impact	-0.01	medium_impact	-0.04	medium_impact	0.28	0.8	16.32	12.69	0.42	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14924	14924	T	A	MI.8699	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	178	60	S	T	Tca/Aca	-5.09	0	0	benign	0	neutral	0.41	neutral	4.58	neutral	-2.16	neutral	-0.96	neutral_impact	0.5	0.98	neutral	0.97	neutral	-0.31	0.62	neutral	0.23	0.45	0.24	neutral	0.19	neutral	0.19	neutral	0.35	neutral	3	0.59	neutral	0.71	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.14	medium_impact	-0.74	medium_impact	0.53	0.8	20.53	23.72	0.56	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8566	8566	A	G	MI.87	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	40	14	I	V	Atc/Gtc	-0.8	0	0.01	benign	0.01	neutral	0.4	neutral	4.69	neutral	0.08	neutral	-0.53	neutral_impact	-0.06	0.99	neutral	0.95	neutral	0.21	4.78	deleterious	0.68	0.75	0.41	neutral	0.22	neutral	0.52	disease	0.4	neutral	2	0.59	neutral	0.7	deleterious	-6	neutral	0.10	neutral	1.14	medium_impact	0.19	medium_impact	-1.15	low_impact	0.56	0.9	13.72	12.42	0.34	N	0.05	polymorphism	1	0.01	rs3020563	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	8936	8936	T	G	MI.870	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	410	137	L	R	cTt/cGt	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	3.61	deleterious	-5.9	deleterious	-5.41	high_impact	4.61	0.34	damaging	0.09	damaging	4.22	23.90	deleterious	0.12	0.65	0.88	disease	0.81	disease	0.83	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.85	high_impact	0.46	0.9	49.56	8.85	0.62	P	0.99	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14924	14924	T	C	MI.8700	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	178	60	S	P	Tca/Cca	-5.09	0	0	benign	0.33	neutral	0.2	neutral	4.48	deleterious	-3.77	deleterious	-2.94	high_impact	3.9	0.93	neutral	0.43	neutral	2.06	16.61	deleterious	0.08	0.35	0.56	disease	0.83	disease	0.66	disease	0.7	disease	4	0.76	neutral	0.44	neutral	-2	neutral	0.49	deleterious	-0.44	medium_impact	-0.1	medium_impact	2.35	high_impact	0.33	0.8	20.53	23.72	0.4	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14924	14924	T	G	MI.8701	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	178	60	S	A	Tca/Gca	-5.09	0	0	benign	0.05	neutral	0.52	neutral	4.6	neutral	-2.07	neutral	-1.41	low_impact	1.12	0.98	neutral	0.97	neutral	-0.18	1.20	neutral	0.23	0.45	0.3	neutral	0.19	neutral	0.39	neutral	0.35	neutral	3	0.43	neutral	0.74	deleterious	-6	neutral	0.11	neutral	0.46	medium_impact	0.24	medium_impact	-0.18	medium_impact	0.35	0.8	20.53	23.72	0.42	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14925	14925	C	T	MI.8702	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	179	60	S	L	tCa/tTa	-4.86	0	0	benign	0.27	neutral	0.66	neutral	4.5	deleterious	-3.29	deleterious	-3.19	low_impact	1.75	0.96	neutral	0.81	neutral	1.32	12.38	neutral	0.13	0.4	0.32	neutral	0.71	disease	0.43	neutral	0.17	neutral	7	0.24	neutral	0.7	deleterious	-6	neutral	0.37	neutral	-0.33	medium_impact	0.38	medium_impact	0.4	medium_impact	0.38	0.8	20.53	23.72	0.24	N	0.11	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14925	14925	C	G	MI.8703	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	179	60	S	W	tCa/tGa	-4.86	0	0	possibly_damaging	0.89	neutral	0.18	neutral	4.46	deleterious	-6.4	deleterious	-4.23	high_impact	3.76	0.95	neutral	0.47	neutral	3.06	22.40	deleterious	0.07	0.35	0.85	disease	0.83	disease	0.55	disease	0.65	disease	3	0.94	neutral	0.15	neutral	1	deleterious	0.76	deleterious	-1.58	low_impact	-0.14	medium_impact	2.22	high_impact	0.17	0.8	20.53	23.72	0.44	N	0.54	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14927	14927	A	G	MI.8704	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	181	61	T	A	Acc/Gcc	-4.4	0	0.02	benign	0	neutral	0.88	neutral	4.69	neutral	-0.27	neutral	-1.94	medium_impact	2.95	0.95	neutral	0.5	neutral	2.05	16.52	deleterious	0.31	0.45	0.31	neutral	0.37	neutral	0.5	neutral	0.43	neutral	1	0.12	neutral	0.94	deleterious	-3	neutral	0.12	neutral	2.07	high_impact	0.69	medium_impact	1.49	medium_impact	0.24	0.8	21.58	46.35	0.25	N	0.80	polymorphism	1	0.01	rs201551481	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14927	14927	A	C	MI.8705	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	181	61	T	P	Acc/Ccc	-4.4	0	0.02	benign	0.35	neutral	0.33	neutral	4.61	neutral	-0.19	deleterious	-3.19	high_impact	3.85	0.93	neutral	0.29	neutral	3.56	23.10	deleterious	0.05	0.35	0.64	disease	0.77	disease	0.63	disease	0.66	disease	3	0.61	neutral	0.49	deleterious	-2	neutral	0.50	deleterious	-0.48	medium_impact	0.06	medium_impact	2.3	high_impact	0.18	0.8	21.58	46.35	0.32	N	0.95	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14927	14927	A	T	MI.8706	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	181	61	T	S	Acc/Tcc	-4.4	0	0.02	benign	0.04	neutral	0.81	neutral	4.67	neutral	0.89	neutral	-1.25	neutral_impact	0.8	0.96	neutral	0.67	neutral	0.71	8.90	deleterious	0.36	0.5	0.41	neutral	0.31	neutral	0.21	neutral	0.46	neutral	1	0.12	neutral	0.89	deleterious	-6	neutral	0.17	neutral	0.56	medium_impact	0.56	medium_impact	-0.47	medium_impact	0.36	0.8	21.58	46.35	0.28	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14928	14928	C	T	MI.8707	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	182	61	T	I	aCc/aTc	0.64	0	0	benign	0.08	neutral	0.69	neutral	4.6	neutral	-1.37	neutral	-2.18	medium_impact	2.29	0.93	neutral	0.45	neutral	3.55	23.10	deleterious	0.17	0.45	0.31	neutral	0.78	disease	0.28	neutral	0.5	neutral	0	0.21	neutral	0.81	deleterious	-3	neutral	0.24	neutral	0.26	medium_impact	0.41	medium_impact	0.89	medium_impact	0.49	0.8	21.58	46.35	0.24	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14928	14928	C	A	MI.8708	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	182	61	T	N	aCc/aAc	0.64	0	0	benign	0.43	neutral	0.52	neutral	4.67	neutral	-0.89	neutral	-2.45	medium_impact	2.92	0.92	neutral	0.41	neutral	3.21	22.70	deleterious	0.33	0.5	0.56	disease	0.7	disease	0.51	disease	0.51	disease	0	0.44	neutral	0.55	deleterious	-3	neutral	0.46	deleterious	-0.62	medium_impact	0.24	medium_impact	1.46	medium_impact	0.53	0.8	21.58	46.35	0.28	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14928	14928	C	G	MI.8709	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	182	61	T	S	aCc/aGc	0.64	0	0	benign	0.04	neutral	0.81	neutral	4.67	neutral	0.89	neutral	-1.25	neutral_impact	0.8	0.96	neutral	0.67	neutral	0.34	6.09	deleterious	0.36	0.5	0.41	neutral	0.31	neutral	0.21	neutral	0.46	neutral	1	0.12	neutral	0.89	deleterious	-6	neutral	0.17	neutral	0.56	medium_impact	0.56	medium_impact	-0.47	medium_impact	0.36	0.8	21.58	46.35	0.26	N	0.25	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8936	8936	T	C	MI.871	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	410	137	L	P	cTt/cCt	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	3.61	deleterious	-6.49	deleterious	-6.33	high_impact	4.61	0.28	damaging	0.11	damaging	3.89	23.50	deleterious	0.17	0.65	0.46	neutral	0.69	disease	0.75	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-1.4	low_impact	2.85	high_impact	0.59	0.9	49.56	8.85	0.73	P	1.00	disease_causing	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14930	14930	G	C	MI.8710	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	184	62	A	P	Gcc/Ccc	-4.63	0	0	probably_damaging	1	neutral	0.21	neutral	3.64	deleterious	-5.8	deleterious	-4.15	high_impact	4.88	0.84	neutral	0.29	neutral	3.57	23.10	deleterious	0.05	0.35	0.9	disease	0.81	disease	0.8	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.09	medium_impact	3.24	high_impact	0.41	0.8	57.11	8.72	0.74	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14930	14930	G	T	MI.8711	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	184	62	A	S	Gcc/Tcc	-4.63	0	0	probably_damaging	0.99	neutral	0.43	neutral	3.67	deleterious	-5.54	neutral	-2.49	high_impact	3.77	0.83	neutral	0.47	neutral	2.02	16.34	deleterious	0.18	0.45	0.76	disease	0.8	disease	0.6	disease	0.65	disease	3	0.99	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0.16	medium_impact	2.23	high_impact	0.34	0.8	57.11	8.72	0.33	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14930	14930	G	A	MI.8712	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	184	62	A	T	Gcc/Acc	-4.63	0	0	probably_damaging	0.99	neutral	0.41	neutral	3.66	deleterious	-6.51	deleterious	-3.31	high_impact	4.54	0.91	neutral	0.45	neutral	2.58	20.00	deleterious	0.12	0.4	0.81	disease	0.8	disease	0.64	disease	0.64	disease	3	0.99	deleterious	0.21	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0.14	medium_impact	2.93	high_impact	0.69	0.85	57.11	8.72	0.52	N	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14931	14931	C	T	MI.8713	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	185	62	A	V	gCc/gTc	9.13	1	0	probably_damaging	0.99	neutral	0.51	neutral	3.64	deleterious	-7.47	deleterious	-3.31	high_impact	5.57	0.77	neutral	0.5	neutral	2.85	21.60	deleterious	0.11	0.4	0.87	disease	0.82	disease	0.69	disease	0.62	disease	2	0.99	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0.23	medium_impact	3.86	high_impact	0.64	0.8	57.11	8.72	0.76	P	0.84	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14931	14931	C	A	MI.8714	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	185	62	A	D	gCc/gAc	9.13	1	0	probably_damaging	1	neutral	0.23	neutral	3.61	deleterious	-8.41	deleterious	-4.97	high_impact	5.57	0.8	neutral	0.39	neutral	4.27	24.00	deleterious	0.05	0.35	0.92	disease	0.9	disease	0.79	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.06	medium_impact	3.86	high_impact	0.31	0.8	57.11	8.72	0.76	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14931	14931	C	G	MI.8715	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	185	62	A	G	gCc/gGc	9.13	1	0	probably_damaging	0.98	neutral	0.34	neutral	3.65	deleterious	-5.51	deleterious	-3.32	high_impact	4.33	0.82	neutral	0.51	neutral	2.16	17.26	deleterious	0.18	0.45	0.82	disease	0.78	disease	0.7	disease	0.66	disease	3	0.98	neutral	0.18	neutral	2	deleterious	0.85	deleterious	-2.31	low_impact	0.07	medium_impact	2.74	high_impact	0.52	0.8	57.11	8.72	0.66	P	0.83	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14933	14933	T	G	MI.8716	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	187	63	F	V	Ttt/Gtt	-6.01	0	0	probably_damaging	0.99	neutral	0.51	neutral	3.76	deleterious	-5.57	deleterious	-5.82	high_impact	4.9	0.83	neutral	0.08	damaging	3.67	23.20	deleterious	0.11	0.4	0.87	disease	0.72	disease	0.75	disease	0.65	disease	3	0.99	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	0.23	medium_impact	3.26	high_impact	0.12	0.8	56.58	8.88	0.66	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14933	14933	T	A	MI.8717	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	187	63	F	I	Ttt/Att	-6.01	0	0	probably_damaging	0.98	neutral	0.41	neutral	3.75	deleterious	-5.74	deleterious	-4.99	high_impact	5.25	0.88	neutral	0.07	damaging	2.67	20.60	deleterious	0.16	0.45	0.87	disease	0.68	disease	0.76	disease	0.66	disease	3	0.98	deleterious	0.22	neutral	2	deleterious	0.84	deleterious	-2.31	low_impact	0.14	medium_impact	3.57	high_impact	0.23	0.8	56.58	8.88	0.67	P	0.97	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14933	14933	T	C	MI.8718	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	187	63	F	L	Ttt/Ctt	-6.01	0	0	probably_damaging	0.98	neutral	0.65	neutral	3.78	deleterious	-4.26	deleterious	-4.99	high_impact	4.9	0.86	neutral	0.06	damaging	2.16	17.22	deleterious	0.19	0.45	0.76	disease	0.6	disease	0.73	disease	0.69	disease	4	0.97	neutral	0.34	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	0.37	medium_impact	3.26	high_impact	0.27	0.8	56.58	8.88	0.61	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14934	14934	T	C	MI.8719	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	188	63	F	S	tTt/tCt	7.3	1	0	probably_damaging	1	neutral	0.41	neutral	3.75	deleterious	-6.32	deleterious	-6.65	high_impact	5.59	0.85	neutral	0.06	damaging	3.72	23.30	deleterious	0.04	0.35	0.88	disease	0.74	disease	0.73	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.14	medium_impact	3.88	high_impact	0.09	0.8	56.58	8.88	0.73	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8936	8936	T	A	MI.872	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	410	137	L	H	cTt/cAt	-0.1	0	0	probably_damaging	1	deleterious	0	neutral	3.61	deleterious	-6.53	deleterious	-6.31	high_impact	4.61	0.44	damaging	0.09	damaging	4.11	23.70	deleterious	0.16	0.65	0.92	disease	0.73	disease	0.81	disease	0.84	disease	7	1	deleterious	0	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-1.4	low_impact	2.85	high_impact	0.52	0.9	49.56	8.85	0.52	P	0.97	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14934	14934	T	A	MI.8720	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	188	63	F	Y	tTt/tAt	7.3	1	0	probably_damaging	0.98	neutral	1	neutral	4.31	neutral	0.08	neutral	-2.49	high_impact	3.73	0.9	neutral	0.07	damaging	2.31	18.22	deleterious	0.25	0.45	0.43	neutral	0.57	disease	0.67	disease	0.52	disease	0	0.98	neutral	0.51	deleterious	2	deleterious	0.76	deleterious	-2.31	low_impact	1.85	high_impact	2.19	high_impact	0.29	0.8	56.58	8.88	0.49	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14934	14934	T	G	MI.8721	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	188	63	F	C	tTt/tGt	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	3.74	deleterious	-6.9	deleterious	-6.65	high_impact	5.59	0.86	neutral	0.06	damaging	3.94	23.60	deleterious	0.07	0.35	0.96	disease	0.69	disease	0.77	disease	0.7	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.14	medium_impact	3.88	high_impact	0.07	0.8	56.58	8.88	0.69	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14935	14935	T	A	MI.8722	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	189	63	F	L	ttT/ttA	5.69	1	0	probably_damaging	0.98	neutral	0.65	neutral	3.78	deleterious	-4.26	deleterious	-4.99	high_impact	4.9	0.86	neutral	0.06	damaging	2.61	20.30	deleterious	0.19	0.45	0.76	disease	0.6	disease	0.73	disease	0.69	disease	4	0.97	neutral	0.34	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	0.37	medium_impact	3.26	high_impact	0.27	0.8	56.58	8.88	0.73	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14935	14935	T	G	MI.8723	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	189	63	F	L	ttT/ttG	5.69	1	0	probably_damaging	0.98	neutral	0.65	neutral	3.78	deleterious	-4.26	deleterious	-4.99	high_impact	4.9	0.86	neutral	0.06	damaging	2.46	19.21	deleterious	0.19	0.45	0.76	disease	0.6	disease	0.73	disease	0.69	disease	4	0.97	neutral	0.34	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	0.37	medium_impact	3.26	high_impact	0.27	0.8	56.58	8.88	0.72	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14936	14936	T	C	MI.8724	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	190	64	S	P	Tca/Cca	-2.8	0	0	probably_damaging	0.98	neutral	0.2	neutral	4.54	deleterious	-3.73	deleterious	-3.94	high_impact	4.29	0.88	neutral	0.1	damaging	2.12	17.00	deleterious	0.05	0.35	0.69	disease	0.73	disease	0.69	disease	0.64	disease	3	0.99	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	-0.1	medium_impact	2.7	high_impact	0.20	0.8	41.32	12.1	0.42	N	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14936	14936	T	G	MI.8725	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	190	64	S	A	Tca/Gca	-2.8	0	0	probably_damaging	0.92	neutral	0.53	neutral	4.73	neutral	-1.73	neutral	-2.33	medium_impact	2.13	0.92	neutral	0.21	damaging	1.69	14.37	neutral	0.2	0.45	0.35	neutral	0.37	neutral	0.45	neutral	0.41	neutral	2	0.91	neutral	0.31	neutral	1	deleterious	0.57	deleterious	-1.72	low_impact	0.25	medium_impact	0.74	medium_impact	0.35	0.8	41.32	12.1	0.27	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14936	14936	T	A	MI.8726	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	190	64	S	T	Tca/Aca	-2.8	0	0	possibly_damaging	0.86	neutral	0.39	neutral	4.61	neutral	-0.57	neutral	-2.23	medium_impact	2.86	0.86	neutral	0.16	damaging	1.68	14.32	neutral	0.15	0.4	0.47	neutral	0.49	neutral	0.54	disease	0.28	neutral	4	0.87	neutral	0.27	neutral	0	NA	0.67	deleterious	-1.47	low_impact	0.12	medium_impact	1.4	medium_impact	0.34	0.8	41.32	12.1	0.29	N	0.70	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14937	14937	C	G	MI.8727	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	191	64	S	W	tCa/tGa	2.25	0.93	0	probably_damaging	1	neutral	0.19	neutral	4.53	neutral	-1.25	deleterious	-5.56	high_impact	3.9	0.89	neutral	0.13	damaging	4.16	23.80	deleterious	0.06	0.35	0.87	disease	0.8	disease	0.62	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.12	medium_impact	2.35	high_impact	0.14	0.8	41.32	12.1	0.42	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14937	14937	C	T	MI.8728	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	191	64	S	L	tCa/tTa	2.25	0.93	0	probably_damaging	0.99	neutral	0.65	neutral	4.56	neutral	-0.76	deleterious	-4.72	high_impact	3.81	0.88	neutral	0.13	damaging	2.90	21.80	deleterious	0.07	0.35	0.33	neutral	0.74	disease	0.55	disease	0.48	neutral	0	0.99	deleterious	0.33	neutral	2	deleterious	0.72	deleterious	-2.59	low_impact	0.37	medium_impact	2.27	high_impact	0.42	0.8	41.32	12.1	0.36	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14939	14939	T	C	MI.8729	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	193	65	S	P	Tca/Cca	-4.4	0	0	benign	0.02	neutral	0.2	neutral	4.02	deleterious	-5.13	deleterious	-4.17	high_impact	5.58	0.94	neutral	0.08	damaging	3.53	23.10	deleterious	0.04	0.35	0.84	disease	0.69	disease	0.82	disease	0.69	disease	4	0.79	neutral	0.59	deleterious	-2	neutral	0.32	neutral	0.85	medium_impact	-0.1	medium_impact	3.87	high_impact	0.20	0.8	57.11	8.76	0.6	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8938	8938	A	G	MI.873	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	412	138	I	V	Atc/Gtc	-8.66	0	0	probably_damaging	0.93	neutral	0.21	neutral	4.37	neutral	-0.12	neutral	-0.84	low_impact	0.9	0.88	neutral	0.69	neutral	3.04	22.30	deleterious	0.71	0.75	0.34	neutral	0.34	neutral	0.44	neutral	0.43	neutral	1	0.95	neutral	0.14	neutral	-2	neutral	0.64	deleterious	-1.82	low_impact	-0.03	medium_impact	-0.33	medium_impact	0.55	0.9	44.69	8.06	0.44	N	0.77	disease_causing	0.72	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14939	14939	T	G	MI.8730	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	193	65	S	A	Tca/Gca	-4.4	0	0	benign	0.2	neutral	0.51	neutral	4.07	deleterious	-3.63	deleterious	-2.5	high_impact	4.48	0.96	neutral	0.14	damaging	1.88	15.44	deleterious	0.18	0.45	0.59	disease	0.41	neutral	0.72	disease	0.59	disease	2	0.39	neutral	0.66	deleterious	-2	neutral	0.27	neutral	-0.17	medium_impact	0.23	medium_impact	2.87	high_impact	0.35	0.8	57.11	8.76	0.38	N	0.46	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14939	14939	T	A	MI.8731	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	193	65	S	T	Tca/Aca	-4.4	0	0	benign	0.21	neutral	0.39	neutral	4.07	deleterious	-3.56	deleterious	-2.5	high_impact	4.54	0.94	neutral	0.1	damaging	1.90	15.60	deleterious	0.15	0.45	0.55	disease	0.55	disease	0.65	disease	0.63	disease	3	0.53	neutral	0.59	deleterious	-2	neutral	0.29	neutral	-0.19	medium_impact	0.12	medium_impact	2.93	high_impact	0.55	0.8	57.11	8.76	0.37	N	0.70	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14940	14940	C	T	MI.8732	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	194	65	S	L	tCa/tTa	5.69	1	0	probably_damaging	0.96	neutral	0.65	neutral	4.04	deleterious	-4.72	deleterious	-5	high_impact	4.68	0.95	neutral	0.06	damaging	4.46	24.20	deleterious	0.04	0.35	0.79	disease	0.72	disease	0.7	disease	0.67	disease	3	0.95	neutral	0.35	neutral	2	deleterious	0.80	deleterious	-2.02	low_impact	0.37	medium_impact	3.06	high_impact	0.32	0.8	57.11	8.76	0.62	P	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14940	14940	C	G	MI.8733	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	194	65	S	W	tCa/tGa	5.69	1	0	probably_damaging	1	neutral	0.19	neutral	4	deleterious	-7.86	deleterious	-5.84	high_impact	5.58	0.98	neutral	0.1	damaging	4.21	23.90	deleterious	0.06	0.35	0.88	disease	0.77	disease	0.75	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.12	medium_impact	3.87	high_impact	0.09	0.8	57.11	8.76	0.71	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14942	14942	A	C	MI.8734	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	196	66	I	L	Atc/Ctc	-4.86	0	0	benign	0.02	neutral	0.65	neutral	4.66	neutral	-0.51	neutral	-1.59	low_impact	1.81	0.84	neutral	0.54	neutral	1.86	15.35	deleterious	0.27	0.45	0.42	neutral	0.44	neutral	0.43	neutral	0.43	neutral	1	0.31	neutral	0.82	deleterious	-6	neutral	0.20	neutral	0.85	medium_impact	0.37	medium_impact	0.45	medium_impact	0.44	0.8	23.68	38.89	0.27	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14942	14942	A	G	MI.8735	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	196	66	I	V	Atc/Gtc	-4.86	0	0	benign	0	neutral	0.53	neutral	5.06	neutral	1.58	neutral	0.49	neutral_impact	-1.11	0.96	neutral	0.9	neutral	-1.61	0.00	neutral	0.39	0.5	0.2	neutral	0.04	neutral	0.24	neutral	0.2	neutral	6	0.47	neutral	0.77	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	0.25	medium_impact	-2.2	low_impact	0.20	0.8	23.68	38.89	0.41	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14942	14942	A	T	MI.8736	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	196	66	I	F	Atc/Ttc	-4.86	0	0	benign	0.16	neutral	0.7	neutral	4.55	neutral	-2.17	deleterious	-3.29	high_impact	3.81	0.85	neutral	0.58	neutral	2.07	16.63	deleterious	0.1	0.4	0.75	disease	0.73	disease	0.62	disease	0.7	disease	4	0.18	neutral	0.77	deleterious	-2	neutral	0.44	deleterious	-0.06	medium_impact	0.42	medium_impact	2.27	high_impact	0.33	0.8	23.68	38.89	0.28	N	0.92	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14943	14943	T	G	MI.8737	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	197	66	I	S	aTc/aGc	0.87	0.72	0	benign	0.21	neutral	0.45	neutral	4.54	neutral	-2.28	deleterious	-4.29	high_impact	3.6	0.84	neutral	0.55	neutral	2.49	19.41	deleterious	0.03	0.35	0.81	disease	0.74	disease	0.58	disease	0.69	disease	4	0.46	neutral	0.62	deleterious	-2	neutral	0.46	deleterious	-0.19	medium_impact	0.18	medium_impact	2.08	high_impact	0.05	0.8	23.68	38.89	0.3	N	0.94	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14943	14943	T	C	MI.8738	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	197	66	I	T	aTc/aCc	0.87	0.72	0	benign	0.08	neutral	0.39	neutral	4.68	neutral	0.18	deleterious	-2.79	medium_impact	3.12	0.84	neutral	0.54	neutral	1.58	13.72	neutral	0.06	0.35	0.67	disease	0.5	disease	0.5	neutral	0.52	disease	0	0.56	neutral	0.66	deleterious	-3	neutral	0.32	neutral	0.26	medium_impact	0.12	medium_impact	1.64	medium_impact	0.12	0.8	23.68	38.89	0.31	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14943	14943	T	A	MI.8739	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	197	66	I	N	aTc/aAc	0.87	0.72	0	possibly_damaging	0.6	neutral	0.31	neutral	4.52	deleterious	-3.77	deleterious	-5.12	high_impact	3.81	0.83	neutral	0.56	neutral	2.79	21.30	deleterious	0.06	0.35	0.89	disease	0.82	disease	0.62	disease	0.69	disease	4	0.71	neutral	0.36	neutral	1	deleterious	0.72	deleterious	-0.9	medium_impact	0.03	medium_impact	2.27	high_impact	0.09	0.8	23.68	38.89	0.35	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8938	8938	A	C	MI.874	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	412	138	I	L	Atc/Ctc	-8.66	0	0	probably_damaging	0.93	neutral	0.1	neutral	4.22	neutral	-1.24	neutral	-1.76	medium_impact	2.21	0.72	neutral	0.46	neutral	3.82	23.40	deleterious	0.48	0.65	0.31	neutral	0.55	disease	0.63	disease	0.64	disease	3	0.97	neutral	0.09	neutral	1	deleterious	0.65	deleterious	-1.82	low_impact	-0.25	medium_impact	0.8	medium_impact	0.70	0.9	44.69	8.06	0.38	N	0.83	disease_causing	0.85	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14944	14944	C	A	MI.8740	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	198	66	I	M	atC/atA	7.3	0.98	0.08	benign	0.43	neutral	0.22	neutral	4.56	neutral	-1.65	neutral	-1.77	medium_impact	2.29	0.84	neutral	0.47	neutral	2.12	16.98	deleterious	0.2	0.45	0.7	disease	0.47	neutral	0.42	neutral	0.57	disease	1	0.75	neutral	0.4	neutral	-3	neutral	0.50	deleterious	-0.62	medium_impact	-0.08	medium_impact	0.89	medium_impact	0.29	0.8	23.68	38.89	0.57	P	0.80	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14944	14944	C	G	MI.8741	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	198	66	I	M	atC/atG	7.3	0.98	0.08	benign	0.43	neutral	0.22	neutral	4.56	neutral	-1.65	neutral	-1.77	medium_impact	2.29	0.84	neutral	0.47	neutral	1.64	14.07	neutral	0.2	0.45	0.7	disease	0.47	neutral	0.42	neutral	0.57	disease	1	0.75	neutral	0.4	neutral	-3	neutral	0.50	deleterious	-0.62	medium_impact	-0.08	medium_impact	0.89	medium_impact	0.29	0.8	23.68	38.89	0.58	P	0.80	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14945	14945	G	C	MI.8742	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	199	67	A	P	Gcc/Ccc	-16.1	0	0	probably_damaging	1	neutral	0.2	neutral	4.59	neutral	-2.14	deleterious	-3.18	high_impact	4.29	0.84	neutral	0.39	neutral	3.71	23.30	deleterious	0.03	0.35	0.52	disease	0.89	disease	0.69	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.1	medium_impact	2.7	high_impact	0.48	0.8	22.37	25.43	0.43	N	0.79	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14945	14945	G	A	MI.8743	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	199	67	A	T	Gcc/Acc	-16.1	0	0	probably_damaging	1	neutral	0.42	neutral	4.67	neutral	-0.29	neutral	-1.45	low_impact	1.05	0.94	neutral	0.97	neutral	1.26	12.07	neutral	0.1	0.4	0.19	neutral	0.31	neutral	0.27	neutral	0.43	neutral	1	1	deleterious	0.21	neutral	-2	neutral	0.68	deleterious	-3.53	low_impact	0.15	medium_impact	-0.24	medium_impact	0.63	0.8	22.37	25.43	0.41	N	0.00	polymorphism	1	0.02	.	.	.	.	.	.	COSM1155579	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14945	14945	G	T	MI.8744	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	199	67	A	S	Gcc/Tcc	-16.1	0	0	probably_damaging	1	neutral	0.47	neutral	4.65	neutral	-0.13	neutral	-1.57	low_impact	1.5	0.9	neutral	0.83	neutral	2.03	16.39	deleterious	0.15	0.4	0.27	neutral	0.71	disease	0.23	neutral	0.2	neutral	6	1	deleterious	0.24	neutral	-2	neutral	0.76	deleterious	-3.53	low_impact	0.19	medium_impact	0.17	medium_impact	0.49	0.8	22.37	25.43	0.31	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14946	14946	C	G	MI.8745	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	200	67	A	G	gCc/gGc	-0.04	0	0	probably_damaging	0.99	neutral	0.34	neutral	4.6	neutral	-1.55	deleterious	-2.8	medium_impact	3.5	0.82	neutral	0.59	neutral	2.27	17.94	deleterious	0.14	0.4	0.43	neutral	0.78	disease	0.54	disease	0.62	disease	2	0.99	deleterious	0.18	neutral	1	deleterious	0.76	deleterious	-2.59	low_impact	0.07	medium_impact	1.98	medium_impact	0.65	0.8	22.37	25.43	0.32	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14946	14946	C	T	MI.8746	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	200	67	A	V	gCc/gTc	-0.04	0	0	probably_damaging	1	neutral	0.63	neutral	4.63	neutral	-0.99	neutral	-2.03	low_impact	1.14	0.91	neutral	0.77	neutral	2.97	22.10	deleterious	0.06	0.35	0.37	neutral	0.66	disease	0.32	neutral	0.2	neutral	6	1	deleterious	0.32	neutral	-2	neutral	0.74	deleterious	-3.53	low_impact	0.35	medium_impact	-0.16	medium_impact	0.64	0.8	22.37	25.43	0.24	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14946	14946	C	A	MI.8747	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	200	67	A	D	gCc/gAc	-0.04	0	0	probably_damaging	1	neutral	0.23	neutral	4.62	neutral	-0.63	deleterious	-3.75	high_impact	3.84	0.8	neutral	0.47	neutral	4.44	24.20	deleterious	0.02	0.35	0.32	neutral	0.9	disease	0.59	disease	0.65	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.06	medium_impact	2.29	high_impact	0.35	0.8	22.37	25.43	0.35	N	0.92	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14948	14948	C	G	MI.8748	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	202	68	H	D	Cac/Gac	-6.01	0	0	probably_damaging	0.99	neutral	0.21	neutral	4.6	neutral	-2.98	deleterious	-7.4	high_impact	4.63	0.84	neutral	0.08	damaging	2.10	16.84	deleterious	0.04	0.35	0.79	disease	0.88	disease	0.71	disease	0.67	disease	3	0.99	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	-0.09	medium_impact	3.01	high_impact	0.28	0.8	56.05	8.33	0.44	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14948	14948	C	A	MI.8749	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	202	68	H	N	Cac/Aac	-6.01	0	0	probably_damaging	0.98	neutral	0.31	neutral	4.56	neutral	-0.83	deleterious	-5.73	medium_impact	3.5	0.85	neutral	0.1	damaging	2.05	16.51	deleterious	0.13	0.4	0.76	disease	0.87	disease	0.65	disease	0.66	disease	3	0.98	deleterious	0.17	neutral	1	deleterious	0.83	deleterious	-2.31	low_impact	0.03	medium_impact	1.98	medium_impact	0.28	0.8	56.05	8.33	0.26	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8938	8938	A	T	MI.875	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	412	138	I	F	Atc/Ttc	-8.66	0	0	probably_damaging	0.99	neutral	0.15	neutral	4.13	neutral	-2.84	deleterious	-3.52	high_impact	3.9	0.72	neutral	0.45	neutral	3.82	23.40	deleterious	0.41	0.65	0.67	disease	0.68	disease	0.69	disease	0.67	disease	3	0.99	deleterious	0.08	neutral	2	deleterious	0.80	deleterious	-2.65	low_impact	-0.13	medium_impact	2.25	high_impact	0.77	0.9	44.69	8.06	0.39	N	0.97	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14948	14948	C	T	MI.8750	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	202	68	H	Y	Cac/Tac	-6.01	0	0	probably_damaging	0.97	neutral	1	neutral	4.63	neutral	-2.79	deleterious	-4.94	medium_impact	2.96	0.9	neutral	0.09	damaging	1.87	15.38	deleterious	0.06	0.35	0.51	disease	0.88	disease	0.53	disease	0.46	neutral	1	0.97	neutral	0.52	deleterious	1	deleterious	0.81	deleterious	-2.14	low_impact	1.85	high_impact	1.49	medium_impact	0.22	0.8	56.05	8.33	0.19	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14949	14949	A	C	MI.8751	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	203	68	H	P	cAc/cCc	2.25	0.95	0	probably_damaging	0.99	neutral	0.2	neutral	4.52	deleterious	-3.42	deleterious	-8.24	high_impact	5.08	0.9	neutral	0.07	damaging	1.50	13.29	neutral	0.02	0.35	0.87	disease	0.89	disease	0.79	disease	0.64	disease	3	0.99	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-2.59	low_impact	-0.1	medium_impact	3.42	high_impact	0.19	0.8	56.05	8.33	0.7	P	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14949	14949	A	G	MI.8752	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	203	68	H	R	cAc/cGc	2.25	0.95	0	probably_damaging	0.97	neutral	0.35	neutral	4.58	neutral	-2.42	deleterious	-6.58	high_impact	3.85	0.86	neutral	0.07	damaging	1.15	11.50	neutral	0.05	0.35	0.44	neutral	0.88	disease	0.63	disease	0.68	disease	4	0.97	neutral	0.19	neutral	2	deleterious	0.81	deleterious	-2.14	low_impact	0.08	medium_impact	2.3	high_impact	0.31	0.8	56.05	8.33	0.42	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14949	14949	A	T	MI.8753	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	203	68	H	L	cAc/cTc	2.25	0.95	0	probably_damaging	0.97	neutral	0.65	neutral	4.54	neutral	0.53	deleterious	-9.04	high_impact	3.96	0.88	neutral	0.08	damaging	2.06	16.61	deleterious	0.02	0.35	0.72	disease	0.91	disease	0.67	disease	0.69	disease	4	0.97	neutral	0.34	neutral	2	deleterious	0.85	deleterious	-2.14	low_impact	0.37	medium_impact	2.4	high_impact	0.14	0.8	56.05	8.33	0.38	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14950	14950	C	A	MI.8754	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	204	68	H	Q	caC/caA	6.84	0.99	0	probably_damaging	0.98	neutral	0.29	neutral	4.57	neutral	-2.13	deleterious	-6.57	high_impact	4.63	0.88	neutral	0.08	damaging	2.07	16.64	deleterious	0.08	0.35	0.7	disease	0.84	disease	0.65	disease	0.68	disease	4	0.98	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	0.01	medium_impact	3.01	high_impact	0.43	0.8	56.05	8.33	0.57	P	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14950	14950	C	G	MI.8755	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	204	68	H	Q	caC/caG	6.84	0.99	0	probably_damaging	0.98	neutral	0.29	neutral	4.57	neutral	-2.13	deleterious	-6.57	high_impact	4.63	0.88	neutral	0.08	damaging	1.67	14.21	neutral	0.08	0.35	0.7	disease	0.84	disease	0.65	disease	0.68	disease	4	0.98	deleterious	0.16	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	0.01	medium_impact	3.01	high_impact	0.43	0.8	56.05	8.33	0.57	P	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14951	14951	A	G	MI.8756	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	205	69	I	V	Atc/Gtc	-1.65	0	0	possibly_damaging	0.87	neutral	0.51	neutral	4.02	deleterious	-3.39	neutral	-0.71	high_impact	4.24	0.91	neutral	0.49	neutral	0.94	10.34	neutral	0.26	0.45	0.39	neutral	0.51	disease	0.59	disease	0.62	disease	2	0.86	neutral	0.32	neutral	1	deleterious	0.59	deleterious	-1.5	low_impact	0.23	medium_impact	2.66	high_impact	0.43	0.8	56.32	8.73	0.42	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14951	14951	A	T	MI.8757	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	205	69	I	F	Atc/Ttc	-1.65	0	0	probably_damaging	0.99	neutral	0.71	neutral	3.96	deleterious	-4.72	deleterious	-3.1	high_impact	4.58	0.85	neutral	0.36	neutral	1.97	16.02	deleterious	0.05	0.35	0.79	disease	0.85	disease	0.69	disease	0.67	disease	3	0.99	deleterious	0.36	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	0.43	medium_impact	2.97	high_impact	0.62	0.8	56.32	8.73	0.41	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14951	14951	A	C	MI.8758	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	205	69	I	L	Atc/Ctc	-1.65	0	0	probably_damaging	0.95	neutral	0.66	neutral	4.13	neutral	-2.01	neutral	-1.46	medium_impact	2.86	0.84	neutral	0.35	neutral	1.72	14.54	neutral	0.15	0.4	0.38	neutral	0.67	disease	0.53	disease	0.45	neutral	1	0.94	neutral	0.36	neutral	1	deleterious	0.52	deleterious	-1.92	low_impact	0.38	medium_impact	1.4	medium_impact	0.63	0.8	56.32	8.73	0.2	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14952	14952	T	C	MI.8759	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	206	69	I	T	aTc/aCc	8.44	1	0	probably_damaging	1	neutral	0.4	neutral	3.96	deleterious	-4.63	deleterious	-3.67	medium_impact	2.84	0.85	neutral	0.42	neutral	3.29	22.80	deleterious	0.02	0.35	0.63	disease	0.69	disease	0.49	neutral	0.18	neutral	6	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.53	low_impact	0.13	medium_impact	1.39	medium_impact	0.27	0.8	56.32	8.73	0.52	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8939	8939	T	C	MI.876	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	413	138	I	T	aTc/aCc	7.07	1	0	probably_damaging	0.99	neutral	0.25	neutral	4.18	neutral	-1.8	deleterious	-4.32	medium_impact	2.93	0.84	neutral	0.56	neutral	3.38	22.90	deleterious	0.42	0.65	0.38	neutral	0.61	disease	0.59	disease	0.48	neutral	0	0.99	deleterious	0.13	neutral	1	deleterious	0.75	deleterious	-2.65	low_impact	0.02	medium_impact	1.41	medium_impact	0.63	0.9	44.69	8.06	0.51	P	0.99	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14952	14952	T	G	MI.8760	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	206	69	I	S	aTc/aGc	8.44	1	0	probably_damaging	1	neutral	0.43	neutral	3.94	deleterious	-5.07	deleterious	-4.56	high_impact	4.79	0.84	neutral	0.38	neutral	4.18	23.80	deleterious	0.01	0.35	0.86	disease	0.87	disease	0.66	disease	0.64	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.16	medium_impact	3.16	high_impact	0.33	0.8	56.32	8.73	0.78	P	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14952	14952	T	A	MI.8761	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	206	69	I	N	aTc/aAc	8.44	1	0	probably_damaging	1	neutral	0.32	neutral	3.92	deleterious	-6.42	deleterious	-5.4	high_impact	5.48	0.83	neutral	0.36	neutral	4.34	24.00	deleterious	0.03	0.35	0.92	disease	0.86	disease	0.68	disease	0.61	disease	2	1	deleterious	0.16	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.05	medium_impact	3.78	high_impact	0.29	0.8	56.32	8.73	0.74	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14953	14953	C	A	MI.8762	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	207	69	I	M	atC/atA	2.25	0.98	0	probably_damaging	1	neutral	0.23	neutral	3.95	deleterious	-4.8	neutral	-2.07	high_impact	3.56	0.83	neutral	0.44	neutral	3.28	22.80	deleterious	0.08	0.35	0.75	disease	0.61	disease	0.57	disease	0.36	neutral	3	1	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.06	medium_impact	2.04	high_impact	0.52	0.8	56.32	8.73	0.47	N	0.83	polymorphism	1	0.06	rs879117423	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	14953	14953	C	G	MI.8763	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	207	69	I	M	atC/atG	2.25	0.98	0	probably_damaging	1	neutral	0.23	neutral	3.95	deleterious	-4.8	neutral	-2.07	high_impact	3.56	0.83	neutral	0.44	neutral	2.83	21.50	deleterious	0.08	0.35	0.75	disease	0.61	disease	0.57	disease	0.36	neutral	3	1	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.06	medium_impact	2.04	high_impact	0.52	0.8	56.32	8.73	0.47	N	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14954	14954	A	C	MI.8764	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	208	70	T	P	Act/Cct	-3.26	0	0	probably_damaging	0.99	neutral	0.2	neutral	4.6	neutral	-2.43	neutral	-2.04	medium_impact	2.63	0.84	neutral	0.44	neutral	3.04	22.30	deleterious	0.04	0.35	0.58	disease	0.91	disease	0.66	disease	0.78	disease	6	1	deleterious	0.11	neutral	1	deleterious	0.88	deleterious	-2.59	low_impact	-0.1	medium_impact	1.19	medium_impact	0.31	0.8	23.95	54.05	0.27	N	0.91	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14954	14954	A	G	MI.8765	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	208	70	T	A	Act/Gct	-3.26	0	0	probably_damaging	0.98	neutral	0.49	neutral	4.67	neutral	-0.5	neutral	0.11	medium_impact	2.17	0.74	neutral	0.77	neutral	1.68	14.32	neutral	0.14	0.4	0.26	neutral	0.62	disease	0.52	disease	0.56	disease	1	0.98	deleterious	0.26	neutral	1	deleterious	0.72	deleterious	-2.31	low_impact	0.21	medium_impact	0.78	medium_impact	0.35	0.8	23.95	54.05	0.36	N	0.19	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14954	14954	A	T	MI.8766	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	208	70	T	S	Act/Tct	-3.26	0	0	probably_damaging	0.98	neutral	0.41	neutral	4.71	neutral	0.51	neutral	-0.28	neutral_impact	0.12	0.84	neutral	0.63	neutral	1.54	13.54	neutral	0.19	0.45	0.35	neutral	0.63	disease	0.22	neutral	0.19	neutral	6	0.98	deleterious	0.22	neutral	-2	neutral	0.75	deleterious	-2.31	low_impact	0.14	medium_impact	-1.08	low_impact	0.62	0.8	23.95	54.05	0.3	N	0.29	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14955	14955	C	G	MI.8767	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	209	70	T	S	aCt/aGt	3.63	0.99	0	probably_damaging	0.98	neutral	0.41	neutral	4.71	neutral	0.51	neutral	-0.28	neutral_impact	0.12	0.84	neutral	0.63	neutral	1.74	14.66	neutral	0.19	0.45	0.35	neutral	0.63	disease	0.22	neutral	0.19	neutral	6	0.98	deleterious	0.22	neutral	-2	neutral	0.75	deleterious	-2.31	low_impact	0.14	medium_impact	-1.08	low_impact	0.62	0.8	23.95	54.05	0.41	N	0.29	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14955	14955	C	A	MI.8768	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	209	70	T	N	aCt/aAt	3.63	0.99	0	probably_damaging	0.99	neutral	0.35	neutral	4.63	neutral	-0.81	neutral	-1.74	medium_impact	2.01	0.83	neutral	0.63	neutral	1.91	15.67	deleterious	0.17	0.45	0.52	disease	0.87	disease	0.52	disease	0.73	disease	5	0.99	deleterious	0.18	neutral	1	deleterious	0.83	deleterious	-2.59	low_impact	0.08	medium_impact	0.63	medium_impact	0.46	0.8	23.95	54.05	0.41	N	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14955	14955	C	T	MI.8769	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	209	70	T	I	aCt/aTt	3.63	0.99	0	probably_damaging	0.99	neutral	0.55	neutral	4.72	neutral	-0.01	neutral	-0.81	low_impact	0.82	0.82	neutral	0.67	neutral	3.46	23.00	deleterious	0.07	0.35	0.22	neutral	0.85	disease	0.49	neutral	0.68	disease	4	0.99	deleterious	0.28	neutral	-2	neutral	0.76	deleterious	-2.59	low_impact	0.27	medium_impact	-0.45	medium_impact	0.63	0.8	23.95	54.05	0.31	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8939	8939	T	A	MI.877	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	413	138	I	N	aTc/aAc	7.07	1	0	probably_damaging	1	neutral	0.15	neutral	4.1	deleterious	-3.89	deleterious	-6.15	medium_impact	2.19	0.74	neutral	0.48	neutral	4.40	24.10	deleterious	0.27	0.65	0.66	disease	0.73	disease	0.69	disease	0.61	disease	2	1	deleterious	0.08	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	-0.13	medium_impact	0.78	medium_impact	0.73	0.9	44.69	8.06	0.5	N	1.00	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14957	14957	C	T	MI.8770	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	211	71	R	W	Cga/Tga	-1.65	0	0	probably_damaging	1	neutral	0.19	neutral	4.4	deleterious	-5.73	deleterious	-6.67	high_impact	4.82	0.84	neutral	0.06	damaging	5.07	25.30	deleterious	0.05	0.35	0.63	disease	0.93	disease	0.73	disease	0.77	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.12	medium_impact	3.18	high_impact	0.73	0.85	58.68	8.72	0.6	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14957	14957	C	G	MI.8771	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	211	71	R	G	Cga/Gga	-1.65	0	0	probably_damaging	0.99	neutral	0.33	neutral	4.43	neutral	-2.93	deleterious	-5.83	high_impact	4.7	0.82	neutral	0.06	damaging	2.51	19.53	deleterious	0.04	0.35	0.76	disease	0.88	disease	0.71	disease	0.68	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0.06	medium_impact	3.07	high_impact	0.26	0.8	58.68	8.72	0.53	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14958	14958	G	A	MI.8772	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	212	71	R	Q	cGa/cAa	3.4	0.99	0	probably_damaging	0.99	neutral	0.29	neutral	4.5	neutral	-1.91	deleterious	-3.33	high_impact	3.75	0.85	neutral	0.04	damaging	2.67	20.60	deleterious	0.09	0.35	0.63	disease	0.87	disease	0.66	disease	0.67	disease	3	0.99	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.01	medium_impact	2.21	high_impact	0.74	0.85	58.68	8.72	0.5	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14958	14958	G	C	MI.8773	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	212	71	R	P	cGa/cCa	3.4	0.99	0	probably_damaging	1	neutral	0.2	neutral	4.41	deleterious	-3.5	deleterious	-5.83	high_impact	4.82	0.86	neutral	0.04	damaging	3.81	23.40	deleterious	0.03	0.35	0.82	disease	0.91	disease	0.81	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.1	medium_impact	3.18	high_impact	0.20	0.8	58.68	8.72	0.7	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14958	14958	G	T	MI.8774	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	212	71	R	L	cGa/cTa	3.4	0.99	0	probably_damaging	0.98	neutral	0.65	neutral	4.43	neutral	-2.5	deleterious	-5.84	high_impact	4.47	0.84	neutral	0.04	damaging	2.44	19.09	deleterious	0.04	0.35	0.61	disease	0.94	disease	0.7	disease	0.78	disease	6	0.98	deleterious	0.34	neutral	2	deleterious	0.88	deleterious	-2.31	low_impact	0.37	medium_impact	2.87	high_impact	0.14	0.8	58.68	8.72	0.43	N	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14960	14960	G	T	MI.8775	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	214	72	D	Y	Gac/Tac	0.64	0.99	0	probably_damaging	1	neutral	1	neutral	4.36	deleterious	-4.41	deleterious	-7.07	high_impact	4.91	0.92	neutral	0.11	damaging	3.87	23.50	deleterious	0.03	0.35	0.92	disease	0.96	disease	0.8	disease	0.63	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.92	deleterious	-3.53	low_impact	1.85	high_impact	3.26	high_impact	0.08	0.8	57.11	8.41	0.6	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14960	14960	G	A	MI.8776	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	214	72	D	N	Gac/Aac	0.64	0.99	0	probably_damaging	1	neutral	0.31	neutral	4.43	neutral	-2.13	deleterious	-3.57	medium_impact	2.28	0.88	neutral	0.13	damaging	3.92	23.50	deleterious	0.33	0.5	0.53	disease	0.81	disease	0.53	disease	0.22	neutral	6	1	deleterious	0.16	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.03	medium_impact	0.88	medium_impact	0.82	0.85	57.11	8.41	0.41	N	0.99	polymorphism	1	0.03	.	.	.	.	.	.	COSM1636967	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14960	14960	G	C	MI.8777	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	214	72	D	H	Gac/Cac	0.64	0.99	0	probably_damaging	1	neutral	0.54	neutral	4.37	deleterious	-3.77	deleterious	-5.34	high_impact	4.91	0.91	neutral	0.1	damaging	3.54	23.10	deleterious	0.05	0.35	0.82	disease	0.89	disease	0.85	disease	0.72	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.26	medium_impact	3.26	high_impact	0.39	0.8	57.11	8.41	0.66	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14961	14961	A	C	MI.8778	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	215	72	D	A	gAc/gCc	3.4	1	0	probably_damaging	1	neutral	0.5	neutral	4.42	neutral	-2.53	deleterious	-6.29	high_impact	5.11	0.93	neutral	0.13	damaging	3.35	22.90	deleterious	0.05	0.35	0.75	disease	0.89	disease	0.78	disease	0.69	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.22	medium_impact	3.45	high_impact	0.21	0.8	57.11	8.41	0.71	P	0.94	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14961	14961	A	G	MI.8779	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	215	72	D	G	gAc/gGc	3.4	1	0	probably_damaging	1	neutral	0.33	neutral	4.38	neutral	-2.44	deleterious	-5.46	high_impact	4.55	0.92	neutral	0.14	damaging	3.81	23.40	deleterious	0.05	0.35	0.75	disease	0.91	disease	0.82	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.06	medium_impact	2.94	high_impact	0.26	0.8	57.11	8.41	0.61	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8939	8939	T	G	MI.878	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	413	138	I	S	aTc/aGc	7.07	1	0	probably_damaging	0.99	neutral	0.12	neutral	4.13	neutral	-2.74	deleterious	-5.22	medium_impact	2.22	0.74	neutral	0.57	neutral	4.23	23.90	deleterious	0.26	0.65	0.58	disease	0.75	disease	0.61	disease	0.56	disease	1	0.99	deleterious	0.07	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	-0.2	medium_impact	0.81	medium_impact	0.68	0.9	44.69	8.06	0.47	N	0.98	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14961	14961	A	T	MI.8780	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	215	72	D	V	gAc/gTc	3.4	1	0	probably_damaging	1	neutral	0.51	neutral	4.38	deleterious	-4.54	deleterious	-7.13	high_impact	5.46	0.92	neutral	0.12	damaging	3.59	23.20	deleterious	0.03	0.35	0.89	disease	0.95	disease	0.78	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.23	medium_impact	3.76	high_impact	0.06	0.8	57.11	8.41	0.7	P	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14962	14962	C	G	MI.8781	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	216	72	D	E	gaC/gaG	8.44	1	0	probably_damaging	0.99	neutral	0.27	neutral	4.61	neutral	-0.68	deleterious	-2.96	medium_impact	3.36	0.91	neutral	0.13	damaging	2.16	17.26	deleterious	0.18	0.45	0.34	neutral	0.87	disease	0.52	disease	0.47	neutral	1	0.99	deleterious	0.14	neutral	1	deleterious	0.81	deleterious	-2.59	low_impact	-0.01	medium_impact	1.86	medium_impact	0.51	0.8	57.11	8.41	0.55	P	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14962	14962	C	A	MI.8782	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	216	72	D	E	gaC/gaA	8.44	1	0	probably_damaging	0.99	neutral	0.27	neutral	4.61	neutral	-0.68	deleterious	-2.96	medium_impact	3.36	0.91	neutral	0.13	damaging	2.53	19.64	deleterious	0.18	0.45	0.34	neutral	0.87	disease	0.52	disease	0.47	neutral	1	0.99	deleterious	0.14	neutral	1	deleterious	0.81	deleterious	-2.59	low_impact	-0.01	medium_impact	1.86	medium_impact	0.51	0.8	57.11	8.41	0.56	P	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14963	14963	G	C	MI.8783	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	217	73	V	L	Gta/Cta	-4.63	0	0	probably_damaging	0.96	neutral	0.65	neutral	4.03	neutral	-2.84	deleterious	-2.52	high_impact	4.32	0.93	neutral	0.08	damaging	1.63	14.04	neutral	0.13	0.4	0.46	neutral	0.81	disease	0.71	disease	0.68	disease	4	0.95	neutral	0.35	neutral	2	deleterious	0.80	deleterious	-2.02	low_impact	0.37	medium_impact	2.73	high_impact	0.46	0.8	55.79	8.15	0.3	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14963	14963	G	T	MI.8784	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	217	73	V	L	Gta/Tta	-4.63	0	0	probably_damaging	0.96	neutral	0.65	neutral	4.03	neutral	-2.84	deleterious	-2.52	high_impact	4.32	0.93	neutral	0.08	damaging	1.73	14.60	neutral	0.13	0.4	0.46	neutral	0.81	disease	0.71	disease	0.68	disease	4	0.95	neutral	0.35	neutral	2	deleterious	0.80	deleterious	-2.02	low_impact	0.37	medium_impact	2.73	high_impact	0.46	0.8	55.79	8.15	0.3	N	0.69	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14963	14963	G	A	MI.8785	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	217	73	V	M	Gta/Ata	-4.63	0	0	probably_damaging	1	neutral	0.22	neutral	3.94	deleterious	-4.4	deleterious	-2.52	high_impact	3.82	0.92	neutral	0.11	damaging	3.56	23.10	deleterious	0.1	0.4	0.8	disease	0.78	disease	0.63	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.08	medium_impact	2.28	high_impact	0.70	0.85	55.79	8.15	0.39	N	0.97	polymorphism	1	0.07	.	.	.	.	.	colonic crypts	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14964	14964	T	G	MI.8786	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	218	73	V	G	gTa/gGa	5	1	0	probably_damaging	1	neutral	0.33	neutral	3.91	deleterious	-5.77	deleterious	-5.89	high_impact	4.71	0.92	neutral	0.11	damaging	3.71	23.30	deleterious	0.01	0.35	0.92	disease	0.84	disease	0.74	disease	0.63	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.06	medium_impact	3.08	high_impact	0.20	0.8	55.79	8.15	0.73	P	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14964	14964	T	A	MI.8787	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	218	73	V	E	gTa/gAa	5	1	0	probably_damaging	1	neutral	0.28	neutral	3.91	deleterious	-6.21	deleterious	-5.05	high_impact	4.62	0.91	neutral	0.08	damaging	4.56	24.40	deleterious	0.01	0.35	0.93	disease	0.9	disease	0.81	disease	0.63	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0	medium_impact	3	high_impact	0.11	0.8	55.79	8.15	0.72	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14964	14964	T	C	MI.8788	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	218	73	V	A	gTa/gCa	5	1	0	probably_damaging	1	neutral	0.51	neutral	3.97	deleterious	-3.97	deleterious	-3.37	high_impact	4.62	0.93	neutral	0.12	damaging	3.10	22.50	deleterious	0.06	0.35	0.77	disease	0.7	disease	0.75	disease	0.7	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.23	medium_impact	3	high_impact	0.12	0.8	55.79	8.15	0.64	P	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14966	14966	A	G	MI.8789	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	220	74	N	D	Aat/Gat	-6.24	0	0	probably_damaging	0.97	neutral	0.21	neutral	4.56	neutral	0.36	deleterious	-2.88	high_impact	3.71	0.84	neutral	0.09	damaging	1.97	16.05	deleterious	0.49	0.55	0.38	neutral	0.83	disease	0.55	disease	0.63	disease	3	0.98	neutral	0.12	neutral	2	deleterious	0.78	deleterious	-2.14	low_impact	-0.09	medium_impact	2.18	high_impact	0.24	0.8	56.58	8.8	0.3	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	COSM1155581	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8940	8940	C	G	MI.879	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	414	138	I	M	atC/atG	5.91	1	0	probably_damaging	1	neutral	0.5	neutral	4.19	neutral	-1.61	deleterious	-2.62	low_impact	1.66	0.79	neutral	0.57	neutral	3.45	23.00	deleterious	0.53	0.65	0.42	neutral	0.27	neutral	0.41	neutral	0.42	neutral	2	0.99	deleterious	0.25	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.29	medium_impact	0.33	medium_impact	0.83	0.9	44.69	8.06	0.49	P	0.75	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14966	14966	A	C	MI.8790	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	220	74	N	H	Aat/Cat	-6.24	0	0	probably_damaging	1	neutral	0.55	neutral	4.51	neutral	-1.78	deleterious	-2.85	high_impact	3.85	0.9	neutral	0.09	damaging	2.78	21.30	deleterious	0.28	0.45	0.34	neutral	0.82	disease	0.6	disease	0.54	disease	1	1	deleterious	0.28	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.27	medium_impact	2.3	high_impact	0.17	0.8	56.58	8.8	0.23	N	0.82	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14966	14966	A	T	MI.8791	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	220	74	N	Y	Aat/Tat	-6.24	0	0	probably_damaging	1	neutral	1	neutral	4.5	deleterious	-3.32	deleterious	-4.85	high_impact	3.98	0.86	neutral	0.08	damaging	3.49	23.10	deleterious	0.06	0.35	0.7	disease	0.92	disease	0.67	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.87	deleterious	-3.53	low_impact	1.85	high_impact	2.42	high_impact	0.19	0.8	56.58	8.8	0.22	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14967	14967	A	T	MI.8792	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	221	74	N	I	aAt/aTt	4.31	0.99	0	probably_damaging	1	neutral	0.4	neutral	4.5	deleterious	-3.07	deleterious	-5.95	high_impact	4.79	0.86	neutral	0.09	damaging	3.48	23.10	deleterious	0.07	0.35	0.65	disease	0.93	disease	0.61	disease	0.69	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.13	medium_impact	3.16	high_impact	0.15	0.8	56.58	8.8	0.64	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14967	14967	A	C	MI.8793	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	221	74	N	T	aAt/aCt	4.31	0.99	0	probably_damaging	0.98	neutral	0.39	neutral	4.56	neutral	-1.41	deleterious	-3.68	high_impact	3.89	0.86	neutral	0.11	damaging	1.48	13.21	neutral	0.25	0.45	0.43	neutral	0.83	disease	0.54	disease	0.49	neutral	0	0.98	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-2.31	low_impact	0.12	medium_impact	2.34	high_impact	0.23	0.8	56.58	8.8	0.47	N	0.78	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14967	14967	A	G	MI.8794	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	221	74	N	S	aAt/aGt	4.31	0.99	0	probably_damaging	0.92	neutral	0.4	neutral	4.58	neutral	-0.97	deleterious	-2.82	medium_impact	2.8	0.85	neutral	0.18	damaging	1.02	10.79	neutral	0.47	0.55	0.38	neutral	0.8	disease	0.55	disease	0.49	neutral	0	0.92	neutral	0.24	neutral	1	deleterious	0.79	deleterious	-1.72	low_impact	0.13	medium_impact	1.35	medium_impact	0.17	0.8	56.58	8.8	0.38	N	0.87	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14968	14968	T	A	MI.8795	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	222	74	N	K	aaT/aaA	6.84	1	0.01	probably_damaging	0.99	neutral	0.29	neutral	4.59	neutral	-0.61	deleterious	-3.17	medium_impact	2.87	0.86	neutral	0.07	damaging	3.82	23.40	deleterious	0.32	0.5	0.32	neutral	0.86	disease	0.61	disease	0.66	disease	3	0.99	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-2.59	low_impact	0.01	medium_impact	1.41	medium_impact	0.39	0.8	56.58	8.8	0.48	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14968	14968	T	G	MI.8796	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	222	74	N	K	aaT/aaG	6.84	1	0.01	probably_damaging	0.99	neutral	0.29	neutral	4.59	neutral	-0.61	deleterious	-3.17	medium_impact	2.87	0.86	neutral	0.07	damaging	3.55	23.10	deleterious	0.32	0.5	0.32	neutral	0.86	disease	0.61	disease	0.66	disease	3	0.99	deleterious	0.15	neutral	1	deleterious	0.81	deleterious	-2.59	low_impact	0.01	medium_impact	1.41	medium_impact	0.39	0.8	56.58	8.8	0.47	N	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14969	14969	T	C	MI.8797	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	223	75	Y	H	Tat/Cat	-1.65	0	0	probably_damaging	1	neutral	0.55	neutral	4.44	deleterious	-3.63	deleterious	-3.45	medium_impact	2.37	0.94	neutral	0.62	neutral	2.15	17.19	deleterious	0.13	0.4	0.67	disease	0.77	disease	0.57	disease	0.35	neutral	3	1	deleterious	0.28	neutral	1	deleterious	0.85	deleterious	-3.53	low_impact	0.27	medium_impact	0.96	medium_impact	0.11	0.8	22.63	7.89	0.24	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14969	14969	T	G	MI.8798	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	223	75	Y	D	Tat/Gat	-1.65	0	0	probably_damaging	1	neutral	0.2	neutral	4.43	deleterious	-4.22	deleterious	-7.49	high_impact	4.85	0.9	neutral	0.36	neutral	3.59	23.20	deleterious	0.04	0.35	0.58	disease	0.92	disease	0.8	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.1	medium_impact	3.21	high_impact	0.07	0.8	22.63	7.89	0.68	P	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14969	14969	T	A	MI.8799	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	223	75	Y	N	Tat/Aat	-1.65	0	0	probably_damaging	1	neutral	0.34	neutral	4.46	neutral	-2.37	deleterious	-6.65	medium_impact	2.36	0.91	neutral	0.46	neutral	3.86	23.50	deleterious	0.07	0.35	0.29	neutral	0.88	disease	0.53	disease	0.22	neutral	6	1	deleterious	0.17	neutral	1	deleterious	0.81	deleterious	-3.53	low_impact	0.07	medium_impact	0.95	medium_impact	0.10	0.8	22.63	7.89	0.36	N	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8566	8566	A	T	MI.88	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	40	14	I	F	Atc/Ttc	-0.8	0	0.01	possibly_damaging	0.68	neutral	0.67	neutral	4.63	neutral	-1.5	neutral	-1.05	neutral_impact	-0.22	0.89	neutral	0.92	neutral	1.93	15.79	deleterious	0.53	0.65	0.65	disease	0.4	neutral	0.34	neutral	0.62	disease	2	0.62	neutral	0.5	deleterious	-3	neutral	0.58	deleterious	-1.07	low_impact	0.47	medium_impact	-1.29	low_impact	0.76	0.9	13.72	12.42	0.33	N	0.53	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8940	8940	C	A	MI.880	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	414	138	I	M	atC/atA	5.91	1	0	probably_damaging	1	neutral	0.5	neutral	4.19	neutral	-1.61	deleterious	-2.62	low_impact	1.66	0.79	neutral	0.57	neutral	3.89	23.50	deleterious	0.53	0.65	0.42	neutral	0.27	neutral	0.41	neutral	0.42	neutral	2	0.99	deleterious	0.25	neutral	-2	neutral	0.70	deleterious	-3.6	low_impact	0.29	medium_impact	0.33	medium_impact	0.83	0.9	44.69	8.06	0.49	P	0.75	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14970	14970	A	G	MI.8800	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	224	75	Y	C	tAt/tGt	3.63	0.98	0	probably_damaging	1	neutral	0.18	neutral	4.43	deleterious	-3.96	deleterious	-6.86	high_impact	4.22	0.92	neutral	0.32	neutral	3.40	23.00	deleterious	0.04	0.35	0.8	disease	0.9	disease	0.68	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.14	medium_impact	2.64	high_impact	0.04	0.8	22.63	7.89	0.55	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14970	14970	A	C	MI.8801	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	224	75	Y	S	tAt/tCt	3.63	0.98	0	probably_damaging	1	neutral	0.4	neutral	4.49	neutral	-1.93	deleterious	-6.71	medium_impact	3.39	0.93	neutral	0.48	neutral	3.37	22.90	deleterious	0.07	0.35	0.29	neutral	0.89	disease	0.56	disease	0.62	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.13	medium_impact	1.88	medium_impact	0.12	0.8	22.63	7.89	0.51	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14970	14970	A	T	MI.8802	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	224	75	Y	F	tAt/tTt	3.63	0.98	0	probably_damaging	0.97	neutral	0.7	neutral	4.63	neutral	0.01	deleterious	-2.52	medium_impact	1.96	0.95	neutral	0.47	neutral	1.46	13.11	neutral	0.24	0.45	0.41	neutral	0.78	disease	0.45	neutral	0.16	neutral	7	0.96	neutral	0.37	neutral	1	deleterious	0.83	deleterious	-2.14	low_impact	0.42	medium_impact	0.59	medium_impact	0.28	0.8	22.63	7.89	0.38	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14972	14972	G	A	MI.8803	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	226	76	G	S	Ggc/Agc	-1.65	0	0	probably_damaging	1	neutral	0.4	neutral	3.14	deleterious	-6.14	deleterious	-5.09	high_impact	4.91	0.84	neutral	0.04	damaging	4.15	23.80	deleterious	0.05	0.35	0.87	disease	0.84	disease	0.75	disease	0.63	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.13	medium_impact	3.26	high_impact	0.49	0.8	58.42	8.64	0.7	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14972	14972	G	C	MI.8804	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	226	76	G	R	Ggc/Cgc	-1.65	0	0	probably_damaging	1	neutral	0.35	neutral	3.1	deleterious	-7.18	deleterious	-6.79	high_impact	5.25	0.79	neutral	0.03	damaging	3.92	23.50	deleterious	0.03	0.35	0.95	disease	0.88	disease	0.84	disease	0.66	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.93	deleterious	-3.53	low_impact	0.08	medium_impact	3.57	high_impact	0.42	0.8	58.42	8.64	0.66	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14972	14972	G	T	MI.8805	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	226	76	G	C	Ggc/Tgc	-1.65	0	0	probably_damaging	1	neutral	0.17	neutral	3.09	deleterious	-8.67	deleterious	-7.64	high_impact	4.7	0.81	neutral	0.02	damaging	4.07	23.70	deleterious	0.03	0.35	0.96	disease	0.89	disease	0.78	disease	0.64	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	-0.15	medium_impact	3.07	high_impact	0.20	0.8	58.42	8.64	0.57	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14973	14973	G	A	MI.8806	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	227	76	G	D	gGc/gAc	5	1	0	probably_damaging	1	neutral	0.2	neutral	3.1	deleterious	-7.66	deleterious	-5.94	high_impact	5.05	0.78	neutral	0.04	damaging	3.70	23.30	deleterious	0.03	0.35	0.88	disease	0.89	disease	0.85	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.1	medium_impact	3.39	high_impact	0.13	0.8	58.42	8.64	0.73	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	COSM1138289	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14973	14973	G	T	MI.8807	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	227	76	G	V	gGc/gTc	5	1	0	probably_damaging	1	neutral	0.5	neutral	3.11	deleterious	-7.24	deleterious	-7.64	high_impact	5.6	0.81	neutral	0.06	damaging	3.68	23.30	deleterious	0.02	0.35	0.94	disease	0.89	disease	0.8	disease	0.63	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.22	medium_impact	3.89	high_impact	0.12	0.8	58.42	8.64	0.7	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14973	14973	G	C	MI.8808	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	227	76	G	A	gGc/gCc	5	1	0	probably_damaging	1	neutral	0.5	neutral	3.15	deleterious	-5.67	deleterious	-5.09	high_impact	5.25	0.86	neutral	0.07	damaging	2.89	21.80	deleterious	0.05	0.35	0.85	disease	0.76	disease	0.78	disease	0.68	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.22	medium_impact	3.57	high_impact	0.34	0.8	58.42	8.64	0.75	P	0.83	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14975	14975	T	C	MI.8809	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	229	77	W	R	Tga/Cga	-5.32	0	0	probably_damaging	1	neutral	0.35	neutral	4.35	neutral	-2.43	deleterious	-11.87	high_impact	4.54	0.78	neutral	0.06	damaging	3.44	23.00	deleterious	0.03	0.35	0.9	disease	0.92	disease	0.85	disease	0.63	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.08	medium_impact	2.93	high_impact	0.09	0.8	57.37	8.71	0.55	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8941	8941	C	A	MI.881	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	415	139	P	T	Ccc/Acc	-4.73	0	0	probably_damaging	1	deleterious	0.03	neutral	4.02	deleterious	-3.34	deleterious	-7	high_impact	4.2	0.66	neutral	0.39	neutral	3.70	23.30	deleterious	0.29	0.65	0.78	disease	0.7	disease	0.69	disease	0.67	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-0.56	medium_impact	2.5	high_impact	0.86	0.9	48.23	8.84	0.36	N	0.93	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14975	14975	T	G	MI.8810	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	229	77	W	G	Tga/Gga	-5.32	0	0	probably_damaging	1	neutral	0.35	neutral	4.33	neutral	-2.88	deleterious	-11.02	high_impact	5.03	0.83	neutral	0.1	damaging	3.53	23.10	deleterious	0.04	0.35	0.91	disease	0.89	disease	0.83	disease	0.62	disease	2	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.08	medium_impact	3.37	high_impact	0.07	0.8	57.37	8.71	0.68	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14976	14976	G	T	MI.8811	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	230	77	W	L	tGa/tTa	5.69	1	0	probably_damaging	1	neutral	0.66	neutral	4.44	neutral	-1	deleterious	-11.03	high_impact	5.23	0.85	neutral	0.07	damaging	3.78	23.40	deleterious	0.04	0.35	0.66	disease	0.9	disease	0.82	disease	0.73	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.38	medium_impact	3.56	high_impact	0.09	0.8	57.37	8.71	0.7	P	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14976	14976	G	C	MI.8812	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	230	77	W	S	tGa/tCa	5.69	1	0	probably_damaging	1	neutral	0.4	neutral	4.4	neutral	-1.35	deleterious	-11.87	high_impact	4.25	0.85	neutral	0.09	damaging	3.68	23.30	deleterious	0.03	0.35	0.85	disease	0.93	disease	0.82	disease	0.66	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.13	medium_impact	2.67	high_impact	0.06	0.8	57.37	8.71	0.61	P	0.99	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14977	14977	A	C	MI.8813	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	231	77	W	C	tgA/tgC	9.13	1	0	probably_damaging	1	neutral	0.18	neutral	4.31	deleterious	-4.87	deleterious	-11.02	high_impact	5.23	0.83	neutral	0.05	damaging	3.88	23.50	deleterious	0.03	0.35	0.93	disease	0.92	disease	0.85	disease	0.65	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.56	high_impact	0.09	0.8	57.37	8.71	0.65	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14977	14977	A	T	MI.8814	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	231	77	W	C	tgA/tgT	9.13	1	0	probably_damaging	1	neutral	0.18	neutral	4.31	deleterious	-4.87	deleterious	-11.02	high_impact	5.23	0.83	neutral	0.05	damaging	4.03	23.60	deleterious	0.03	0.35	0.93	disease	0.92	disease	0.85	disease	0.65	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.56	high_impact	0.09	0.8	57.37	8.71	0.66	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14978	14978	A	G	MI.8815	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	232	78	I	V	Atc/Gtc	3.17	0.99	0	benign	0	neutral	0.53	neutral	4.7	neutral	0.07	neutral	-0.74	low_impact	0.82	0.99	neutral	0.97	neutral	0.02	2.81	deleterious	0.32	0.5	0.21	neutral	0.37	neutral	0.4	neutral	0.42	neutral	2	0.47	neutral	0.77	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	0.25	medium_impact	-0.45	medium_impact	0.44	0.8	23.68	26.02	0.39	N	0.50	polymorphism	1	0.01	rs199997767	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14978	14978	A	T	MI.8816	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	232	78	I	F	Atc/Ttc	3.17	0.99	0	benign	0.33	neutral	0.77	neutral	4.66	neutral	0.07	neutral	-1.82	neutral_impact	0.73	0.97	neutral	0.6	neutral	2.12	17.00	deleterious	0.1	0.4	0.68	disease	0.73	disease	0.39	neutral	0.23	neutral	5	0.22	neutral	0.72	deleterious	-6	neutral	0.44	deleterious	-0.44	medium_impact	0.51	medium_impact	-0.53	medium_impact	0.67	0.85	23.68	26.02	0.33	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14978	14978	A	C	MI.8817	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	232	78	I	L	Atc/Ctc	3.17	0.99	0	benign	0.02	neutral	0.76	neutral	5.05	neutral	1.81	neutral	1.18	neutral_impact	-1.9	0.96	neutral	0.92	neutral	-0.83	0.04	neutral	0.2	0.45	0.16	neutral	0.11	neutral	0.27	neutral	0.21	neutral	6	0.19	neutral	0.87	deleterious	-6	neutral	0.09	neutral	0.85	medium_impact	0.49	medium_impact	-2.92	low_impact	0.75	0.85	23.68	26.02	0.43	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14979	14979	T	C	MI.8818	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	233	78	I	T	aTc/aCc	-1.42	0	0.11	possibly_damaging	0.84	neutral	0.4	neutral	4.58	neutral	-1.72	deleterious	-2.5	medium_impact	2.11	1	neutral	0.81	neutral	2.27	17.94	deleterious	0.06	0.35	0.63	disease	0.58	disease	0.56	disease	0.58	disease	2	0.84	neutral	0.28	neutral	0	NA	0.23	neutral	-1.4	low_impact	0.13	medium_impact	0.72	medium_impact	0.31	0.8	23.68	26.02	0.37	N	0.70	polymorphism	1	0.03	rs200786872	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	14979	14979	T	A	MI.8819	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	233	78	I	N	aTc/aAc	-1.42	0	0.11	probably_damaging	0.98	neutral	0.37	neutral	4.54	deleterious	-3.39	deleterious	-4.23	medium_impact	3.36	0.93	neutral	0.51	neutral	4.48	24.20	deleterious	0.05	0.35	0.86	disease	0.85	disease	0.59	disease	0.7	disease	4	0.98	deleterious	0.2	neutral	1	deleterious	0.80	deleterious	-2.31	low_impact	0.1	medium_impact	1.86	medium_impact	0.33	0.8	23.68	26.02	0.38	N	0.82	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8941	8941	C	T	MI.882	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	415	139	P	S	Ccc/Tcc	-4.73	0	0	probably_damaging	1	neutral	0.08	neutral	4.05	deleterious	-3.77	deleterious	-7	medium_impact	3.23	0.57	damaging	0.52	neutral	3.93	23.50	deleterious	0.34	0.65	0.67	disease	0.68	disease	0.72	disease	0.65	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	-0.31	medium_impact	1.67	medium_impact	0.42	0.9	48.23	8.84	0.33	N	0.82	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14979	14979	T	G	MI.8820	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	233	78	I	S	aTc/aGc	-1.42	0	0.11	probably_damaging	0.91	neutral	0.44	neutral	4.56	neutral	-2.13	deleterious	-3.38	medium_impact	3	0.94	neutral	0.49	neutral	4.18	23.80	deleterious	0.02	0.35	0.75	disease	0.76	disease	0.6	disease	0.7	disease	4	0.9	neutral	0.27	neutral	1	deleterious	0.47	deleterious	-1.67	low_impact	0.17	medium_impact	1.53	medium_impact	0.31	0.8	23.68	26.02	0.32	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14980	14980	C	A	MI.8821	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	234	78	I	M	atC/atA	4.54	0.66	0	benign	0.04	neutral	0.24	neutral	4.6	neutral	-0.87	neutral	-0.24	neutral_impact	0.31	0.96	neutral	0.74	neutral	2.26	17.89	deleterious	0.19	0.45	0.64	disease	0.44	neutral	0.35	neutral	0.58	disease	2	0.74	neutral	0.6	deleterious	-6	neutral	0.20	neutral	0.56	medium_impact	-0.05	medium_impact	-0.91	medium_impact	0.63	0.8	23.68	26.02	0.38	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14980	14980	C	G	MI.8822	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	234	78	I	M	atC/atG	4.54	0.66	0	benign	0.04	neutral	0.24	neutral	4.6	neutral	-0.87	neutral	-0.24	neutral_impact	0.31	0.96	neutral	0.74	neutral	1.76	14.73	neutral	0.19	0.45	0.64	disease	0.44	neutral	0.35	neutral	0.58	disease	2	0.74	neutral	0.6	deleterious	-6	neutral	0.20	neutral	0.56	medium_impact	-0.05	medium_impact	-0.91	medium_impact	0.63	0.8	23.68	26.02	0.38	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14981	14981	A	T	MI.8823	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	235	79	I	F	Atc/Ttc	-8.07	0	0	possibly_damaging	0.65	neutral	0.77	neutral	4.43	neutral	-2.08	deleterious	-3.05	medium_impact	2.94	0.95	neutral	0.43	neutral	2.08	16.71	deleterious	0.07	0.35	0.37	neutral	0.85	disease	0.48	neutral	0.59	disease	2	0.58	neutral	0.56	deleterious	0	NA	0.69	deleterious	-0.98	medium_impact	0.51	medium_impact	1.48	medium_impact	0.72	0.85	18.16	18.79	0.26	N	0.89	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14981	14981	A	C	MI.8824	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	235	79	I	L	Atc/Ctc	-8.07	0	0	benign	0.08	neutral	0.81	neutral	4.67	neutral	0.05	neutral	-1.22	low_impact	1.12	0.96	neutral	0.9	neutral	0.67	8.61	deleterious	0.23	0.45	0.15	neutral	0.53	disease	0.36	neutral	0.21	neutral	6	0.09	neutral	0.87	deleterious	-6	neutral	0.16	neutral	0.26	medium_impact	0.56	medium_impact	-0.18	medium_impact	0.73	0.85	18.16	18.79	0.27	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14981	14981	A	G	MI.8825	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	235	79	I	V	Atc/Gtc	-8.07	0	0	benign	0	neutral	0.51	neutral	4.54	neutral	-0.65	neutral	-0.73	medium_impact	2.66	0.98	neutral	0.65	neutral	1.10	11.22	neutral	0.44	0.55	0.37	neutral	0.51	disease	0.56	disease	0.31	neutral	4	0.49	neutral	0.76	deleterious	-3	neutral	0.16	neutral	2.07	high_impact	0.23	medium_impact	1.22	medium_impact	0.59	0.8	18.16	18.79	0.32	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14982	14982	T	C	MI.8826	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	236	79	I	T	aTc/aCc	3.63	0.99	0	probably_damaging	0.91	neutral	0.36	neutral	4.37	neutral	-2.78	deleterious	-3.71	high_impact	4.25	0.92	neutral	0.45	neutral	3.29	22.80	deleterious	0.04	0.35	0.74	disease	0.82	disease	0.57	disease	0.62	disease	2	0.92	neutral	0.23	neutral	2	deleterious	0.75	deleterious	-1.67	low_impact	0.09	medium_impact	2.67	high_impact	0.33	0.8	18.16	18.79	0.54	N	0.69	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14982	14982	T	G	MI.8827	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	236	79	I	S	aTc/aGc	3.63	0.99	0	probably_damaging	0.97	neutral	0.45	neutral	4.36	deleterious	-3.19	deleterious	-4.59	high_impact	4.8	0.94	neutral	0.43	neutral	4.17	23.80	deleterious	0.02	0.35	0.83	disease	0.89	disease	0.61	disease	0.62	disease	2	0.97	neutral	0.24	neutral	2	deleterious	0.85	deleterious	-2.14	low_impact	0.18	medium_impact	3.17	high_impact	0.32	0.8	18.16	18.79	0.71	P	0.89	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14982	14982	T	A	MI.8828	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	236	79	I	N	aTc/aAc	3.63	0.99	0	probably_damaging	0.99	neutral	0.36	neutral	4.34	deleterious	-4.23	deleterious	-5.44	high_impact	4.59	0.93	neutral	0.45	neutral	4.36	24.10	deleterious	0.06	0.35	0.91	disease	0.89	disease	0.63	disease	0.63	disease	3	0.99	deleterious	0.19	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0.09	medium_impact	2.97	high_impact	0.40	0.8	18.16	18.79	0.6	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14983	14983	C	A	MI.8829	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	237	79	I	M	atC/atA	5.69	1	0	possibly_damaging	0.81	neutral	0.22	neutral	4.41	neutral	-1.86	neutral	-1.91	medium_impact	2.27	0.95	neutral	0.39	neutral	3.30	22.90	deleterious	0.16	0.45	0.58	disease	0.58	disease	0.43	neutral	0.21	neutral	6	0.88	neutral	0.21	neutral	0	NA	0.54	deleterious	-1.32	low_impact	-0.08	medium_impact	0.87	medium_impact	0.76	0.85	18.16	18.79	0.55	P	0.81	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8941	8941	C	G	MI.883	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	415	139	P	A	Ccc/Gcc	-4.73	0	0	probably_damaging	1	neutral	0.08	neutral	4.06	neutral	-2.83	deleterious	-7	high_impact	4.2	0.63	neutral	0.47	neutral	3.14	22.60	deleterious	0.24	0.65	0.7	disease	0.5	disease	0.73	disease	0.7	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.78	deleterious	-3.6	low_impact	-0.31	medium_impact	2.5	high_impact	0.82	0.9	48.23	8.84	0.42	N	0.79	disease_causing	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14983	14983	C	G	MI.8830	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	237	79	I	M	atC/atG	5.69	1	0	possibly_damaging	0.81	neutral	0.22	neutral	4.41	neutral	-1.86	neutral	-1.91	medium_impact	2.27	0.95	neutral	0.39	neutral	2.89	21.80	deleterious	0.16	0.45	0.58	disease	0.58	disease	0.43	neutral	0.21	neutral	6	0.88	neutral	0.21	neutral	0	NA	0.54	deleterious	-1.32	low_impact	-0.08	medium_impact	0.87	medium_impact	0.76	0.85	18.16	18.79	0.55	P	0.81	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14984	14984	C	A	MI.8831	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	238	80	R	S	Cgc/Agc	-3.71	0	0	probably_damaging	0.99	neutral	0.4	neutral	3.87	deleterious	-4.63	deleterious	-5.04	high_impact	5.53	0.8	neutral	0.06	damaging	2.92	21.90	deleterious	0.03	0.35	0.87	disease	0.91	disease	0.74	disease	0.62	disease	2	0.99	deleterious	0.21	neutral	2	deleterious	0.91	deleterious	-2.59	low_impact	0.13	medium_impact	3.83	high_impact	0.20	0.8	55.26	8.41	0.7	P	0.74	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14984	14984	C	G	MI.8832	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	238	80	R	G	Cgc/Ggc	-3.71	0	0	probably_damaging	0.99	neutral	0.33	neutral	3.85	deleterious	-5.71	deleterious	-5.89	high_impact	5.18	0.86	neutral	0.08	damaging	2.46	19.19	deleterious	0.03	0.35	0.9	disease	0.87	disease	0.76	disease	0.6	disease	2	0.99	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-2.59	low_impact	0.06	medium_impact	3.51	high_impact	0.20	0.8	55.26	8.41	0.7	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14984	14984	C	T	MI.8833	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	238	80	R	C	Cgc/Tgc	-3.71	0	0	probably_damaging	1	neutral	0.18	neutral	3.83	deleterious	-6.93	deleterious	-6.74	high_impact	5.53	0.86	neutral	0.04	damaging	4.84	24.80	deleterious	0.05	0.35	0.97	disease	0.92	disease	0.78	disease	0.6	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.14	medium_impact	3.83	high_impact	0.49	0.8	55.26	8.41	0.65	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14985	14985	G	C	MI.8834	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	239	80	R	P	cGc/cCc	2.71	0.98	0	probably_damaging	1	neutral	0.2	neutral	3.84	deleterious	-6.24	deleterious	-5.88	high_impact	4.38	0.86	neutral	0.04	damaging	3.88	23.50	deleterious	0.02	0.35	0.93	disease	0.92	disease	0.85	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	-0.1	medium_impact	2.78	high_impact	0.14	0.8	55.26	8.41	0.59	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14985	14985	G	T	MI.8835	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	239	80	R	L	cGc/cTc	2.71	0.98	0	probably_damaging	0.98	neutral	0.65	neutral	3.94	neutral	-2.91	deleterious	-5.88	high_impact	4.98	0.87	neutral	0.06	damaging	2.48	19.36	deleterious	0.03	0.35	0.88	disease	0.95	disease	0.74	disease	0.65	disease	3	0.98	deleterious	0.34	neutral	2	deleterious	0.91	deleterious	-2.31	low_impact	0.37	medium_impact	3.33	high_impact	0.09	0.8	55.26	8.41	0.66	P	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14985	14985	G	A	MI.8836	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	239	80	R	H	cGc/cAc	2.71	0.98	0	probably_damaging	1	neutral	0.54	neutral	3.85	deleterious	-5.21	deleterious	-4.16	medium_impact	3.5	0.82	neutral	0.06	damaging	4.02	23.60	deleterious	0.08	0.35	0.9	disease	0.88	disease	0.74	disease	0.61	disease	2	1	deleterious	0.27	neutral	1	deleterious	0.90	deleterious	-3.53	low_impact	0.26	medium_impact	1.98	medium_impact	0.58	0.8	55.26	8.41	0.48	N	1.00	disease_causing_automatic	0	0.08	rs207459995	Pathogenic	Familial_colorectal_cancer	24715	MedGen:CN029768	colorectal tumor	.	.	0.3	.	.	.	.	.	.	P	.	P	damaging
chrM	14987	14987	T	A	MI.8837	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	241	81	Y	N	Tac/Aac	-13.35	0	0	probably_damaging	0.95	neutral	0.31	neutral	4.68	neutral	-0.62	neutral	3.53	neutral_impact	-0.55	0.88	neutral	0.15	damaging	1.24	11.97	neutral	0.09	0.35	0.48	neutral	0.29	neutral	0.37	neutral	0.4	neutral	2	0.95	neutral	0.18	neutral	-2	neutral	0.74	deleterious	-1.92	low_impact	0.03	medium_impact	-1.69	low_impact	0.40	0.8	18.68	20.01	0.35	N	0.53	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14987	14987	T	C	MI.8838	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	241	81	Y	H	Tac/Cac	-13.35	0	0	benign	0.04	neutral	0.54	neutral	4.6	neutral	-1.16	neutral	1.05	medium_impact	3.4	0.9	neutral	0.51	neutral	2.16	17.22	deleterious	0.13	0.4	0.74	disease	0.84	disease	0.55	disease	0.66	disease	3	0.42	neutral	0.75	deleterious	-3	neutral	0.34	neutral	0.56	medium_impact	0.26	medium_impact	1.89	medium_impact	0.37	0.8	18.68	20.01	0.24	N	0.20	polymorphism	1	0.07	.	.	.	.	.	.	COSM1138291	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14987	14987	T	G	MI.8839	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	241	81	Y	D	Tac/Gac	-13.35	0	0	probably_damaging	0.96	neutral	0.2	neutral	4.59	neutral	-1.19	neutral	0.22	high_impact	3.96	0.83	neutral	0.08	damaging	2.07	16.68	deleterious	0.07	0.35	0.7	disease	0.94	disease	0.65	disease	0.76	disease	5	0.97	neutral	0.12	neutral	2	deleterious	0.88	deleterious	-2.02	low_impact	-0.1	medium_impact	2.4	high_impact	0.24	0.8	18.68	20.01	0.34	N	0.96	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8942	8942	C	G	MI.884	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	416	139	P	R	cCc/cGc	4.52	0.99	0	probably_damaging	1	deleterious	0.01	neutral	4.01	deleterious	-4.74	deleterious	-7.92	high_impact	4.54	0.64	neutral	0.4	neutral	3.63	23.20	deleterious	0.21	0.65	0.8	disease	0.81	disease	0.82	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-0.84	medium_impact	2.79	high_impact	0.78	0.9	48.23	8.84	0.55	P	0.65	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14988	14988	A	T	MI.8840	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	242	81	Y	F	tAc/tTc	2.71	0.98	0	benign	0.4	neutral	0.71	neutral	4.58	neutral	-2.24	neutral	-1.31	medium_impact	3.1	0.87	neutral	0.11	damaging	2.13	17.08	deleterious	0.18	0.45	0.62	disease	0.89	disease	0.45	neutral	0.64	disease	3	0.3	neutral	0.66	deleterious	-3	neutral	0.54	deleterious	-0.57	medium_impact	0.43	medium_impact	1.62	medium_impact	0.52	0.8	18.68	20.01	0.34	N	0.56	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14988	14988	A	C	MI.8841	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	242	81	Y	S	tAc/tCc	2.71	0.98	0	probably_damaging	0.96	neutral	0.4	neutral	4.69	neutral	0.2	neutral	0.58	low_impact	0.96	0.91	neutral	0.12	damaging	2.59	20.10	deleterious	0.07	0.35	0.5	disease	0.84	disease	0.46	neutral	0.16	neutral	7	0.96	neutral	0.22	neutral	-2	neutral	0.73	deleterious	-2.02	low_impact	0.13	medium_impact	-0.32	medium_impact	0.41	0.8	18.68	20.01	0.44	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14988	14988	A	G	MI.8842	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	242	81	Y	C	tAc/tGc	2.71	0.98	0	probably_damaging	0.96	neutral	0.18	neutral	4.54	deleterious	-4.75	neutral	-2.13	high_impact	3.61	0.87	neutral	0.06	damaging	3.88	23.50	deleterious	0.05	0.35	0.78	disease	0.94	disease	0.6	disease	0.73	disease	5	0.98	neutral	0.11	neutral	2	deleterious	0.87	deleterious	-2.02	low_impact	-0.14	medium_impact	2.08	high_impact	0.24	0.8	18.68	20.01	0.43	N	0.93	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14990	14990	C	A	MI.8843	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	244	82	L	I	Ctt/Att	-4.17	0	0.01	probably_damaging	0.98	neutral	0.44	neutral	4.62	neutral	-0.2	neutral	-0.77	neutral_impact	0.56	0.93	neutral	0.91	neutral	1.25	12.01	neutral	0.18	0.45	0.35	neutral	0.51	disease	0.31	neutral	0.25	neutral	5	0.98	deleterious	0.23	neutral	-2	neutral	0.71	deleterious	-2.31	low_impact	0.17	medium_impact	-0.69	medium_impact	0.41	0.8	10.26	19.6	0.34	N	0.45	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14990	14990	C	G	MI.8844	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	244	82	L	V	Ctt/Gtt	-4.17	0	0.01	probably_damaging	0.96	neutral	0.48	neutral	4.56	neutral	-0.64	neutral	-1.33	medium_impact	2.82	0.91	neutral	0.71	neutral	0.48	7.31	deleterious	0.17	0.45	0.51	disease	0.74	disease	0.39	neutral	0.2	neutral	6	0.96	neutral	0.26	neutral	1	deleterious	0.74	deleterious	-2.02	low_impact	0.2	medium_impact	1.37	medium_impact	0.50	0.8	10.26	19.6	0.27	N	0.42	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14990	14990	C	T	MI.8845	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	244	82	L	F	Ctt/Ttt	-4.17	0	0.01	probably_damaging	1	neutral	0.75	neutral	4.45	neutral	-2.31	deleterious	-2.54	medium_impact	2.95	0.77	neutral	0.57	neutral	3.60	23.20	deleterious	0.08	0.35	0.44	neutral	0.86	disease	0.52	disease	0.62	disease	2	0.99	deleterious	0.38	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.48	medium_impact	1.49	medium_impact	0.51	0.8	10.26	19.6	0.18	N	0.53	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14991	14991	T	G	MI.8846	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	245	82	L	R	cTt/cGt	-1.42	0	0	probably_damaging	1	neutral	0.37	neutral	4.4	deleterious	-3.77	deleterious	-4.13	high_impact	4.68	0.84	neutral	0.45	neutral	4.00	23.60	deleterious	0.02	0.35	0.86	disease	0.94	disease	0.71	disease	0.69	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.1	medium_impact	3.06	high_impact	0.20	0.8	10.26	19.6	0.56	N	0.90	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14991	14991	T	A	MI.8847	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	245	82	L	H	cTt/cAt	-1.42	0	0	probably_damaging	1	neutral	0.57	neutral	4.4	deleterious	-4.31	deleterious	-4.81	high_impact	4.68	0.82	neutral	0.46	neutral	3.98	23.60	deleterious	0.03	0.35	0.9	disease	0.86	disease	0.67	disease	0.64	disease	3	1	deleterious	0.29	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.29	medium_impact	3.06	high_impact	0.25	0.8	10.26	19.6	0.52	N	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14991	14991	T	C	MI.8848	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	245	82	L	P	cTt/cCt	-1.42	0	0	probably_damaging	1	neutral	0.2	neutral	4.4	deleterious	-4.35	deleterious	-4.79	high_impact	4.68	0.83	neutral	0.34	neutral	3.73	23.30	deleterious	0.02	0.35	0.89	disease	0.93	disease	0.71	disease	0.67	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.1	medium_impact	3.06	high_impact	0.23	0.8	10.26	19.6	0.56	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	COSM1155583	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	14993	14993	C	G	MI.8849	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	247	83	H	D	Cac/Gac	-4.63	0	0	probably_damaging	0.99	neutral	0.2	neutral	2.78	deleterious	-10.97	deleterious	-7.62	high_impact	5.06	0.92	neutral	0.11	damaging	2.23	17.74	deleterious	0.03	0.35	0.79	disease	0.92	disease	0.87	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	-0.1	medium_impact	3.4	high_impact	0.31	0.8	58.16	8.67	0.59	P	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8942	8942	C	A	MI.885	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	416	139	P	H	cCc/cAc	4.52	0.99	0	probably_damaging	1	deleterious	0.01	neutral	3.94	deleterious	-4.81	deleterious	-7.92	high_impact	4.54	0.6	damaging	0.32	neutral	4.08	23.70	deleterious	0.24	0.65	0.9	disease	0.76	disease	0.81	disease	0.81	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-3.6	low_impact	-0.84	medium_impact	2.79	high_impact	0.73	0.9	48.23	8.84	0.57	P	0.64	disease_causing	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14993	14993	C	T	MI.8850	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	247	83	H	Y	Cac/Tac	-4.63	0	0	probably_damaging	0.98	neutral	1	neutral	2.79	deleterious	-9.56	deleterious	-5.08	high_impact	5.61	0.94	neutral	0.13	damaging	1.92	15.69	deleterious	0.06	0.35	0.81	disease	0.94	disease	0.81	disease	0.74	disease	5	0.98	deleterious	0.51	deleterious	2	deleterious	0.89	deleterious	-2.31	low_impact	1.85	high_impact	3.9	high_impact	0.40	0.8	58.16	8.67	0.67	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14993	14993	C	A	MI.8851	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	247	83	H	N	Cac/Aac	-4.63	0	0	probably_damaging	0.99	neutral	0.34	neutral	2.78	deleterious	-9.41	deleterious	-5.93	high_impact	5.26	0.93	neutral	0.13	damaging	2.10	16.88	deleterious	0.12	0.4	0.83	disease	0.92	disease	0.81	disease	0.67	disease	3	0.99	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0.07	medium_impact	3.58	high_impact	0.43	0.8	58.16	8.67	0.69	P	0.97	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14994	14994	A	C	MI.8852	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	248	83	H	P	cAc/cCc	7.07	1	0	probably_damaging	1	neutral	0.2	neutral	2.77	deleterious	-11.53	deleterious	-8.47	high_impact	4.8	0.95	neutral	0.08	damaging	1.62	13.94	neutral	0.02	0.35	0.91	disease	0.94	disease	0.88	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.1	medium_impact	3.17	high_impact	0.33	0.8	58.16	8.67	0.63	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14994	14994	A	G	MI.8853	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	248	83	H	R	cAc/cGc	7.07	1	0	probably_damaging	0.98	neutral	0.36	neutral	2.79	deleterious	-10.6	deleterious	-6.77	high_impact	5.61	0.94	neutral	0.09	damaging	1.21	11.78	neutral	0.04	0.35	0.78	disease	0.94	disease	0.85	disease	0.79	disease	6	0.99	deleterious	0.19	neutral	2	deleterious	0.90	deleterious	-2.31	low_impact	0.09	medium_impact	3.9	high_impact	0.51	0.8	58.16	8.67	0.67	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14994	14994	A	T	MI.8854	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	248	83	H	L	cAc/cTc	7.07	1	0	probably_damaging	0.98	neutral	0.79	neutral	2.77	deleterious	-11.74	deleterious	-9.31	high_impact	5.61	0.95	neutral	0.11	damaging	1.98	16.11	deleterious	0.03	0.35	0.85	disease	0.96	disease	0.83	disease	0.69	disease	4	0.98	deleterious	0.41	neutral	2	deleterious	0.89	deleterious	-2.31	low_impact	0.53	medium_impact	3.9	high_impact	0.32	0.8	58.16	8.67	0.68	P	0.92	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14995	14995	C	A	MI.8855	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	249	83	H	Q	caC/caA	8.44	1	0	probably_damaging	0.99	neutral	0.28	neutral	2.78	deleterious	-9.82	deleterious	-6.77	high_impact	4.92	0.93	neutral	0.11	damaging	2.13	17.05	deleterious	0.07	0.35	0.81	disease	0.89	disease	0.82	disease	0.69	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0	medium_impact	3.27	high_impact	0.42	0.8	58.16	8.67	0.72	P	0.94	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14995	14995	C	G	MI.8856	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	249	83	H	Q	caC/caG	8.44	1	0	probably_damaging	0.99	neutral	0.28	neutral	2.78	deleterious	-9.82	deleterious	-6.77	high_impact	4.92	0.93	neutral	0.11	damaging	1.79	14.92	neutral	0.07	0.35	0.81	disease	0.89	disease	0.82	disease	0.69	disease	4	0.99	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0	medium_impact	3.27	high_impact	0.42	0.8	58.16	8.67	0.71	P	0.94	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14996	14996	G	T	MI.8857	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	250	84	A	S	Gcc/Tcc	-6.24	0	0.01	benign	0.13	neutral	0.4	neutral	4.55	neutral	-0.38	neutral	-2.31	medium_impact	2.98	0.83	neutral	0.47	neutral	1.88	15.47	deleterious	0.13	0.4	0.43	neutral	0.88	disease	0.54	disease	0.65	disease	3	0.53	neutral	0.64	deleterious	-3	neutral	0.33	neutral	0.04	medium_impact	0.13	medium_impact	1.51	medium_impact	0.46	0.8	51.32	8.13	0.28	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14996	14996	G	A	MI.8858	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	250	84	A	T	Gcc/Acc	-6.24	0	0.01	benign	0	neutral	0.39	neutral	4.47	neutral	-2.45	deleterious	-2.9	high_impact	3.87	0.84	neutral	0.48	neutral	2.52	19.61	deleterious	0.09	0.35	0.66	disease	0.89	disease	0.57	disease	0.53	disease	1	0.6	neutral	0.7	deleterious	-2	neutral	0.32	neutral	2.07	high_impact	0.12	medium_impact	2.32	high_impact	0.71	0.85	51.32	8.13	0.34	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14996	14996	G	C	MI.8859	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	250	84	A	P	Gcc/Ccc	-6.24	0	0.01	possibly_damaging	0.44	neutral	0.2	neutral	4.42	deleterious	-3.86	deleterious	-4.02	high_impact	4.89	0.84	neutral	0.29	neutral	3.42	23.00	deleterious	0.03	0.35	0.8	disease	0.91	disease	0.76	disease	0.68	disease	4	0.77	neutral	0.38	neutral	1	deleterious	0.73	deleterious	-0.63	medium_impact	-0.1	medium_impact	3.25	high_impact	0.48	0.8	51.32	8.13	0.67	P	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8942	8942	C	T	MI.886	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	416	139	P	L	cCc/cTc	4.52	0.99	0	probably_damaging	1	neutral	0.24	neutral	3.95	neutral	-1.94	deleterious	-8.8	medium_impact	3.35	0.56	damaging	0.41	neutral	4.45	24.20	deleterious	0.3	0.65	0.66	disease	0.73	disease	0.7	disease	0.68	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.81	deleterious	-3.6	low_impact	0.01	medium_impact	1.77	medium_impact	0.80	0.9	48.23	8.84	0.49	N	0.95	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14997	14997	C	G	MI.8860	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	251	84	A	G	gCc/gGc	4.08	1	0	benign	0.05	neutral	0.33	neutral	4.45	neutral	-0.81	deleterious	-3.27	high_impact	4.75	0.82	neutral	0.51	neutral	2.06	16.57	deleterious	0.13	0.4	0.72	disease	0.86	disease	0.64	disease	0.68	disease	4	0.64	neutral	0.64	deleterious	-2	neutral	0.35	neutral	0.46	medium_impact	0.06	medium_impact	3.12	high_impact	0.61	0.8	51.32	8.13	0.63	P	0.83	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14997	14997	C	A	MI.8861	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	251	84	A	D	gCc/gAc	4.08	1	0	benign	0.36	neutral	0.21	neutral	4.46	neutral	-2.76	deleterious	-4.8	high_impact	5.44	0.8	neutral	0.39	neutral	4.11	23.70	deleterious	0.02	0.35	0.84	disease	0.94	disease	0.74	disease	0.67	disease	3	0.75	neutral	0.43	neutral	-2	neutral	0.72	deleterious	-0.5	medium_impact	-0.09	medium_impact	3.75	high_impact	0.23	0.8	51.32	8.13	0.65	P	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14997	14997	C	T	MI.8862	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	251	84	A	V	gCc/gTc	4.08	1	0	benign	0.08	neutral	0.5	neutral	4.45	deleterious	-3.23	deleterious	-3.17	high_impact	3.85	0.84	neutral	0.5	neutral	2.70	20.80	deleterious	0.05	0.35	0.71	disease	0.92	disease	0.64	disease	0.69	disease	4	0.43	neutral	0.71	deleterious	-2	neutral	0.56	deleterious	0.26	medium_impact	0.22	medium_impact	2.3	high_impact	0.72	0.85	51.32	8.13	0.52	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14999	14999	A	T	MI.8863	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	253	85	N	Y	Aat/Tat	-9.68	0	0	probably_damaging	1	neutral	1	neutral	4.58	neutral	0.07	deleterious	-6.82	high_impact	5.48	0.78	neutral	0.33	neutral	3.64	23.20	deleterious	0.06	0.35	0.92	disease	0.95	disease	0.72	disease	0.65	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.90	deleterious	-3.53	low_impact	1.85	high_impact	3.78	high_impact	0.26	0.8	58.42	8.75	0.58	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14999	14999	A	C	MI.8864	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	253	85	N	H	Aat/Cat	-9.68	0	0	probably_damaging	1	neutral	0.55	neutral	4.5	neutral	-2.61	deleterious	-4.26	high_impact	5.13	0.82	neutral	0.21	damaging	2.95	22.00	deleterious	0.2	0.45	0.9	disease	0.9	disease	0.76	disease	0.67	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.27	medium_impact	3.46	high_impact	0.28	0.8	58.42	8.75	0.7	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	14999	14999	A	G	MI.8865	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	253	85	N	D	Aat/Gat	-9.68	0	0	probably_damaging	0.99	neutral	0.2	neutral	4.5	neutral	-2.6	deleterious	-4.26	high_impact	3.98	0.79	neutral	0.36	neutral	3.32	22.90	deleterious	0.29	0.45	0.71	disease	0.88	disease	0.72	disease	0.72	disease	4	0.99	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	-0.1	medium_impact	2.42	high_impact	0.28	0.8	58.42	8.75	0.34	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15000	15000	A	C	MI.8866	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	254	85	N	T	aAt/aCt	6.84	1	0	probably_damaging	1	neutral	0.39	neutral	4.6	neutral	0.15	deleterious	-5.11	medium_impact	3.4	0.83	neutral	0.4	neutral	3.18	22.70	deleterious	0.16	0.45	0.57	disease	0.9	disease	0.69	disease	0.71	disease	4	1	deleterious	0.2	neutral	1	deleterious	0.85	deleterious	-3.53	low_impact	0.12	medium_impact	1.89	medium_impact	0.36	0.8	58.42	8.75	0.53	N	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15000	15000	A	G	MI.8867	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	254	85	N	S	aAt/aGt	6.84	1	0	probably_damaging	0.98	neutral	0.4	neutral	4.53	neutral	-1.3	deleterious	-4.25	high_impact	3.94	0.83	neutral	0.4	neutral	1.36	12.56	neutral	0.24	0.45	0.68	disease	0.88	disease	0.71	disease	0.73	disease	5	0.98	neutral	0.21	neutral	2	deleterious	0.85	deleterious	-2.31	low_impact	0.13	medium_impact	2.38	high_impact	0.32	0.8	58.42	8.75	0.62	P	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15000	15000	A	T	MI.8868	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	254	85	N	I	aAt/aTt	6.84	1	0	probably_damaging	1	neutral	0.4	neutral	4.56	neutral	-0.26	deleterious	-7.67	high_impact	3.87	0.84	neutral	0.41	neutral	3.94	23.50	deleterious	0.06	0.35	0.9	disease	0.97	disease	0.73	disease	0.69	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.13	medium_impact	2.32	high_impact	0.20	0.8	58.42	8.75	0.61	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15001	15001	T	G	MI.8869	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	255	85	N	K	aaT/aaG	8.44	1	0.01	probably_damaging	1	neutral	0.29	neutral	4.51	neutral	-1.8	deleterious	-5.11	high_impact	4.5	0.83	neutral	0.28	damaging	3.90	23.50	deleterious	0.18	0.45	0.77	disease	0.93	disease	0.77	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.01	medium_impact	2.89	high_impact	0.54	0.8	58.42	8.75	0.69	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8944	8944	A	G	MI.887	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	418	140	M	V	Ata/Gta	-15.14	0	0	possibly_damaging	0.87	neutral	0.44	neutral	4.55	neutral	1.84	neutral	-1.36	neutral_impact	-0.52	0.9	neutral	0.65	neutral	0.55	7.79	deleterious	0.39	0.65	0.41	neutral	0.21	neutral	0.34	neutral	0.36	neutral	3	0.87	neutral	0.29	neutral	-3	neutral	0.57	deleterious	-1.54	low_impact	0.23	medium_impact	-1.54	low_impact	0.66	0.9	44.25	8.21	0.37	N	0.95	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15001	15001	T	A	MI.8870	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	255	85	N	K	aaT/aaA	8.44	1	0.01	probably_damaging	1	neutral	0.29	neutral	4.51	neutral	-1.8	deleterious	-5.11	high_impact	4.5	0.83	neutral	0.28	damaging	4.15	23.80	deleterious	0.18	0.45	0.77	disease	0.93	disease	0.77	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.01	medium_impact	2.89	high_impact	0.54	0.8	58.42	8.75	0.69	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15002	15002	G	T	MI.8871	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	256	86	G	C	Ggc/Tgc	-2.8	0	0	probably_damaging	0.96	neutral	0.18	neutral	4.15	deleterious	-3.77	deleterious	-7.47	high_impact	5.03	0.79	neutral	0.23	damaging	4.04	23.70	deleterious	0.02	0.35	0.91	disease	0.94	disease	0.71	disease	0.63	disease	3	0.97	neutral	0.11	neutral	2	deleterious	0.87	deleterious	-2.02	low_impact	-0.14	medium_impact	3.37	high_impact	0.26	0.8	58.16	8.68	0.61	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15002	15002	G	C	MI.8872	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	256	86	G	R	Ggc/Cgc	-2.8	0	0	probably_damaging	0.93	neutral	0.35	neutral	4.17	deleterious	-3.21	deleterious	-6.64	high_impact	5.58	0.79	neutral	0.24	damaging	3.87	23.50	deleterious	0.02	0.35	0.91	disease	0.94	disease	0.8	disease	0.66	disease	3	0.93	neutral	0.21	neutral	2	deleterious	0.90	deleterious	-1.78	low_impact	0.08	medium_impact	3.87	high_impact	0.56	0.8	58.16	8.68	0.67	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15002	15002	G	A	MI.8873	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	256	86	G	S	Ggc/Agc	-2.8	0	0	benign	0.11	neutral	0.4	neutral	4.25	neutral	-2.38	deleterious	-4.82	high_impact	4.29	0.63	neutral	0.35	neutral	4.13	23.80	deleterious	0.04	0.35	0.69	disease	0.87	disease	0.66	disease	0.69	disease	4	0.54	neutral	0.65	deleterious	-2	neutral	0.43	neutral	0.12	medium_impact	0.13	medium_impact	2.7	high_impact	0.55	0.8	58.16	8.68	0.37	N	1.00	polymorphism	1	0.04	rs370448948	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15003	15003	G	A	MI.8874	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	257	86	G	D	gGc/gAc	5.92	1	0	possibly_damaging	0.72	neutral	0.2	neutral	4.16	deleterious	-4.12	deleterious	-5.79	high_impact	5.58	0.72	neutral	0.3	neutral	3.70	23.30	deleterious	0.02	0.35	0.88	disease	0.92	disease	0.8	disease	0.64	disease	3	0.85	neutral	0.24	neutral	1	deleterious	0.84	deleterious	-1.11	low_impact	-0.1	medium_impact	3.87	high_impact	0.15	0.8	58.16	8.68	0.76	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	COSM6188316	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15003	15003	G	C	MI.8875	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	257	86	G	A	gGc/gCc	5.92	1	0	benign	0.21	neutral	0.51	neutral	4.41	neutral	-1.68	deleterious	-4.91	high_impact	5.23	0.8	neutral	0.43	neutral	2.87	21.70	deleterious	0.04	0.35	0.65	disease	0.81	disease	0.69	disease	0.67	disease	3	0.39	neutral	0.65	deleterious	-2	neutral	0.61	deleterious	-0.19	medium_impact	0.23	medium_impact	3.56	high_impact	0.47	0.8	58.16	8.68	0.65	P	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15003	15003	G	T	MI.8876	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	257	86	G	V	gGc/gTc	5.92	1	0	probably_damaging	0.93	neutral	0.5	neutral	4.21	neutral	-0.83	deleterious	-7.5	high_impact	4.68	0.79	neutral	0.37	neutral	3.70	23.30	deleterious	0.02	0.35	0.85	disease	0.93	disease	0.72	disease	0.63	disease	3	0.92	neutral	0.29	neutral	2	deleterious	0.86	deleterious	-1.78	low_impact	0.22	medium_impact	3.06	high_impact	0.17	0.8	58.16	8.68	0.61	P	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15005	15005	G	T	MI.8877	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	259	87	A	S	Gcc/Tcc	-6.47	0	0	probably_damaging	0.99	neutral	0.44	neutral	3.75	deleterious	-4	deleterious	-2.55	high_impact	4.26	0.88	neutral	0.08	damaging	2.08	16.72	deleterious	0.13	0.4	0.78	disease	0.88	disease	0.68	disease	0.68	disease	4	0.99	deleterious	0.23	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	0.17	medium_impact	2.67	high_impact	0.39	0.8	57.89	8.66	0.39	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15005	15005	G	A	MI.8878	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	259	87	A	T	Gcc/Acc	-6.47	0	0	probably_damaging	0.99	neutral	0.38	neutral	3.7	deleterious	-5.4	deleterious	-3.37	high_impact	4.68	0.88	neutral	0.08	damaging	3.74	23.30	deleterious	0.08	0.35	0.83	disease	0.89	disease	0.72	disease	0.65	disease	3	0.99	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0.11	medium_impact	3.06	high_impact	0.59	0.8	57.89	8.66	0.58	N	0.79	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15005	15005	G	C	MI.8879	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	259	87	A	P	Gcc/Ccc	-6.47	0	0	probably_damaging	1	neutral	0.2	neutral	3.66	deleterious	-7.12	deleterious	-4.28	high_impact	5.58	0.92	neutral	0.05	damaging	3.58	23.20	deleterious	0.03	0.35	0.91	disease	0.92	disease	0.82	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.1	medium_impact	3.87	high_impact	0.42	0.8	57.89	8.66	0.72	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8944	8944	A	T	MI.888	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	418	140	M	L	Ata/Tta	-15.14	0	0	possibly_damaging	0.81	neutral	0.29	neutral	4.57	neutral	1.99	neutral	-1.45	neutral_impact	-0.2	0.87	neutral	0.64	neutral	2.32	18.31	deleterious	0.37	0.65	0.29	neutral	0.34	neutral	0.38	neutral	0.44	neutral	1	0.85	neutral	0.24	neutral	-3	neutral	0.50	deleterious	-1.35	low_impact	0.07	medium_impact	-1.27	low_impact	0.59	0.9	44.25	8.21	0.38	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15006	15006	C	G	MI.8880	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	260	87	A	G	gCc/gGc	7.07	1	0	probably_damaging	0.98	neutral	0.42	neutral	3.68	deleterious	-5.79	deleterious	-3.42	high_impact	4.54	0.87	neutral	0.08	damaging	2.16	17.27	deleterious	0.13	0.4	0.83	disease	0.87	disease	0.66	disease	0.57	disease	1	0.98	neutral	0.22	neutral	2	deleterious	0.84	deleterious	-2.31	low_impact	0.15	medium_impact	2.93	high_impact	0.60	0.8	57.89	8.66	0.57	P	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15006	15006	C	T	MI.8881	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	260	87	A	V	gCc/gTc	7.07	1	0	probably_damaging	0.99	neutral	0.51	neutral	3.72	deleterious	-5.64	deleterious	-3.42	high_impact	4.11	0.84	neutral	0.08	damaging	2.86	21.70	deleterious	0.07	0.35	0.88	disease	0.92	disease	0.72	disease	0.62	disease	2	0.99	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	0.23	medium_impact	2.54	high_impact	0.61	0.8	57.89	8.66	0.61	P	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15006	15006	C	A	MI.8882	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	260	87	A	D	gCc/gAc	7.07	1	0	probably_damaging	1	neutral	0.2	neutral	3.67	deleterious	-6.99	deleterious	-5.12	high_impact	5.24	0.81	neutral	0.06	damaging	4.29	24.00	deleterious	0.03	0.35	0.93	disease	0.95	disease	0.81	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.1	medium_impact	3.56	high_impact	0.26	0.8	57.89	8.66	0.76	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15008	15008	T	G	MI.8883	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	262	88	S	A	Tca/Gca	-6.93	0	0	probably_damaging	0.99	neutral	0.64	neutral	3.05	neutral	-1.42	deleterious	-2.57	high_impact	4.87	0.88	neutral	0.14	damaging	3.27	22.80	deleterious	0.16	0.45	0.65	disease	0.73	disease	0.66	disease	0.65	disease	3	0.99	deleterious	0.33	neutral	2	deleterious	0.80	deleterious	-2.59	low_impact	0.36	medium_impact	3.23	high_impact	0.52	0.8	57.63	8.68	0.6	P	0.46	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15008	15008	T	A	MI.8884	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	262	88	S	T	Tca/Aca	-6.93	0	0	probably_damaging	0.99	neutral	0.39	neutral	3.04	neutral	-1.8	deleterious	-2.53	high_impact	4.07	0.86	neutral	0.1	damaging	2.09	16.78	deleterious	0.17	0.45	0.75	disease	0.81	disease	0.73	disease	0.68	disease	4	0.99	deleterious	0.2	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.12	medium_impact	2.5	high_impact	0.59	0.8	57.63	8.68	0.32	N	0.70	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15008	15008	T	C	MI.8885	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	262	88	S	P	Tca/Cca	-6.93	0	0	probably_damaging	1	neutral	0.2	neutral	3	deleterious	-3.63	deleterious	-4.29	high_impact	5.42	0.88	neutral	0.04	damaging	3.78	23.40	deleterious	0.05	0.35	0.87	disease	0.89	disease	0.82	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.1	medium_impact	3.73	high_impact	0.36	0.8	57.63	8.68	0.74	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	COSM1155585	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15009	15009	C	G	MI.8886	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	263	88	S	W	tCa/tGa	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	2.98	deleterious	-4.5	deleterious	-6.02	high_impact	5.42	0.89	neutral	0.09	damaging	4.27	24.00	deleterious	0.05	0.35	0.98	disease	0.94	disease	0.76	disease	0.63	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.14	medium_impact	3.73	high_impact	0.13	0.8	57.63	8.68	0.7	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15009	15009	C	T	MI.8887	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	263	88	S	L	tCa/tTa	7.3	1	0	probably_damaging	1	neutral	0.69	neutral	3.12	neutral	-0.93	deleterious	-5.15	high_impact	5.07	0.88	neutral	0.06	damaging	4.56	24.40	deleterious	0.04	0.35	0.89	disease	0.93	disease	0.69	disease	0.63	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.41	medium_impact	3.41	high_impact	0.57	0.8	57.63	8.68	0.7	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15011	15011	A	G	MI.8888	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	265	89	M	V	Ata/Gta	-5.32	0	0	probably_damaging	0.98	neutral	0.43	neutral	3.18	neutral	-0.1	neutral	-1.67	medium_impact	2.5	0.86	neutral	0.64	neutral	0.97	10.48	neutral	0.28	0.45	0.43	neutral	0.84	disease	0.61	disease	0.58	disease	2	0.97	neutral	0.23	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	0.16	medium_impact	1.08	medium_impact	0.33	0.8	20.26	11.43	0.25	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15011	15011	A	T	MI.8889	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	265	89	M	L	Ata/Tta	-5.32	0	0	probably_damaging	0.96	neutral	0.77	neutral	3.29	neutral	0.99	neutral	-0.72	neutral_impact	0.27	0.91	neutral	0.73	neutral	0.30	5.65	deleterious	0.23	0.45	0.16	neutral	0.74	disease	0.44	neutral	0.22	neutral	6	0.96	neutral	0.41	neutral	-2	neutral	0.66	deleterious	-2.02	low_impact	0.51	medium_impact	-0.95	medium_impact	0.27	0.8	20.26	11.43	0.22	N	0.92	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8944	8944	A	C	MI.889	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	418	140	M	L	Ata/Cta	-15.14	0	0	possibly_damaging	0.81	neutral	0.29	neutral	4.57	neutral	1.99	neutral	-1.45	neutral_impact	-0.2	0.87	neutral	0.64	neutral	2.19	17.41	deleterious	0.37	0.65	0.29	neutral	0.34	neutral	0.38	neutral	0.44	neutral	1	0.85	neutral	0.24	neutral	-3	neutral	0.50	deleterious	-1.35	low_impact	0.07	medium_impact	-1.27	low_impact	0.59	0.9	44.25	8.21	0.38	N	0.93	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15011	15011	A	C	MI.8890	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	265	89	M	L	Ata/Cta	-5.32	0	0	probably_damaging	0.96	neutral	0.77	neutral	3.29	neutral	0.99	neutral	-0.72	neutral_impact	0.27	0.91	neutral	0.73	neutral	0.16	4.23	deleterious	0.23	0.45	0.16	neutral	0.74	disease	0.44	neutral	0.22	neutral	6	0.96	neutral	0.41	neutral	-2	neutral	0.66	deleterious	-2.02	low_impact	0.51	medium_impact	-0.95	medium_impact	0.27	0.8	20.26	11.43	0.22	N	0.92	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15012	15012	T	A	MI.8891	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	266	89	M	K	aTa/aAa	0.64	0.25	0	probably_damaging	0.99	neutral	0.25	neutral	3.07	neutral	-2.5	deleterious	-3.7	high_impact	4.25	0.82	neutral	0.37	neutral	2.38	18.70	deleterious	0.02	0.35	0.81	disease	0.94	disease	0.73	disease	0.74	disease	5	0.99	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-2.59	low_impact	-0.04	medium_impact	2.67	high_impact	0.17	0.8	20.26	11.43	0.39	N	0.99	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15012	15012	T	C	MI.8892	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	266	89	M	T	aTa/aCa	0.64	0.25	0	probably_damaging	1	neutral	0.33	neutral	3.11	neutral	-0.9	deleterious	-3.1	medium_impact	3.27	0.91	neutral	0.62	neutral	2.58	19.95	deleterious	0.07	0.35	0.65	disease	0.84	disease	0.65	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.82	deleterious	-3.53	low_impact	0.06	medium_impact	1.78	medium_impact	0.15	0.8	20.26	11.43	0.34	N	0.99	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15013	15013	A	T	MI.8893	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	267	89	M	I	atA/atT	7.3	0.98	0.01	probably_damaging	0.98	neutral	0.43	neutral	3.28	neutral	0.9	neutral	-1.17	medium_impact	2.08	0.9	neutral	0.43	neutral	1.50	13.30	neutral	0.26	0.45	0.39	neutral	0.85	disease	0.5	neutral	0.17	neutral	7	0.98	deleterious	0.23	neutral	1	deleterious	0.78	deleterious	-2.31	low_impact	0.16	medium_impact	0.7	medium_impact	0.37	0.8	20.26	11.43	0.54	N	0.95	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15013	15013	A	C	MI.8894	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	267	89	M	I	atA/atC	7.3	0.98	0.01	probably_damaging	0.98	neutral	0.43	neutral	3.28	neutral	0.9	neutral	-1.17	medium_impact	2.08	0.9	neutral	0.43	neutral	1.43	12.97	neutral	0.26	0.45	0.39	neutral	0.85	disease	0.5	neutral	0.17	neutral	7	0.98	deleterious	0.23	neutral	1	deleterious	0.78	deleterious	-2.31	low_impact	0.16	medium_impact	0.7	medium_impact	0.37	0.8	20.26	11.43	0.53	N	0.95	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15014	15014	T	G	MI.8895	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	268	90	F	V	Ttc/Gtc	-0.27	0.35	0	possibly_damaging	0.68	neutral	0.22	neutral	3.01	neutral	-1.71	deleterious	-5.67	high_impact	4	0.85	neutral	0.5	neutral	3.97	23.60	deleterious	0.06	0.35	0.57	disease	0.91	disease	0.73	disease	0.72	disease	4	0.82	neutral	0.27	neutral	1	deleterious	0.63	deleterious	-1.04	low_impact	-0.08	medium_impact	2.44	high_impact	0.45	0.8	19.47	16.72	0.41	N	0.90	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15014	15014	T	A	MI.8896	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	268	90	F	I	Ttc/Atc	-0.27	0.35	0	benign	0.36	neutral	0.24	neutral	3.02	neutral	-1.77	deleterious	-4.82	high_impact	3.75	0.85	neutral	0.49	neutral	4.20	23.90	deleterious	0.09	0.4	0.71	disease	0.9	disease	0.72	disease	0.7	disease	4	0.72	neutral	0.44	neutral	-2	neutral	0.60	deleterious	-0.5	medium_impact	-0.05	medium_impact	2.21	high_impact	0.65	0.8	19.47	16.72	0.37	N	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15014	15014	T	C	MI.8897	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	268	90	F	L	Ttc/Ctc	-0.27	0.35	0	benign	0.02	neutral	0.56	neutral	3.08	neutral	-1.5	deleterious	-4.75	high_impact	4.41	0.85	neutral	0.6	neutral	3.69	23.30	deleterious	0.13	0.4	0.58	disease	0.86	disease	0.68	disease	0.56	disease	1	0.41	neutral	0.77	deleterious	-2	neutral	0.28	neutral	0.85	medium_impact	0.28	medium_impact	2.81	high_impact	0.66	0.8	19.47	16.72	0.39	N	0.40	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15015	15015	T	G	MI.8898	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	269	90	F	C	tTc/tGc	5.69	1	0	probably_damaging	0.99	neutral	0.08	neutral	2.92	deleterious	-5.21	deleterious	-6.58	high_impact	5.04	0.84	neutral	0.42	neutral	4.00	23.60	deleterious	0.02	0.35	0.94	disease	0.9	disease	0.75	disease	0.64	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	-0.35	medium_impact	3.38	high_impact	0.29	0.8	19.47	16.72	0.69	P	0.96	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15015	15015	T	A	MI.8899	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	269	90	F	Y	tTc/tAc	5.69	1	0	possibly_damaging	0.72	neutral	0.44	neutral	2.97	deleterious	-4.2	neutral	-2.5	high_impact	3.88	0.85	neutral	0.46	neutral	4.10	23.70	deleterious	0.13	0.4	0.65	disease	0.87	disease	0.7	disease	0.7	disease	4	0.72	neutral	0.36	neutral	1	deleterious	0.73	deleterious	-1.11	low_impact	0.17	medium_impact	2.33	high_impact	0.65	0.8	19.47	16.72	0.67	P	0.74	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8566	8566	A	C	MI.89	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	40	14	I	L	Atc/Ctc	-0.8	0	0.01	benign	0.09	neutral	1	neutral	4.74	neutral	0.29	neutral	0.14	neutral_impact	-1.74	0.89	neutral	0.94	neutral	0.32	5.85	deleterious	0.48	0.65	0.32	neutral	0.14	neutral	0.26	neutral	0.23	neutral	5	0.09	neutral	0.96	deleterious	-6	neutral	0.12	neutral	0.2	medium_impact	1.98	high_impact	-2.59	low_impact	0.68	0.9	13.72	12.42	0.31	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8945	8945	T	C	MI.890	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	419	140	M	T	aTa/aCa	1.98	0.58	0	probably_damaging	0.94	deleterious	0.04	neutral	4.41	neutral	0.4	deleterious	-3.55	low_impact	1.84	0.91	neutral	0.59	neutral	1.88	15.47	deleterious	0.29	0.65	0.79	disease	0.39	neutral	0.44	neutral	0.64	disease	3	0.99	deleterious	0.05	neutral	2	deleterious	0.75	deleterious	-1.89	low_impact	-0.49	medium_impact	0.48	medium_impact	0.41	0.9	44.25	8.21	0.38	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15015	15015	T	C	MI.8900	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	269	90	F	S	tTc/tCc	5.69	1	0	probably_damaging	0.94	neutral	0.23	neutral	2.94	deleterious	-4	deleterious	-6.6	high_impact	5.38	0.84	neutral	0.45	neutral	4.21	23.90	deleterious	0.02	0.35	0.88	disease	0.88	disease	0.71	disease	0.63	disease	3	0.96	neutral	0.15	neutral	2	deleterious	0.83	deleterious	-1.85	low_impact	-0.06	medium_impact	3.69	high_impact	0.42	0.8	19.47	16.72	0.73	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15016	15016	C	A	MI.8901	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	270	90	F	L	ttC/ttA	7.3	1	0	benign	0.02	neutral	0.56	neutral	3.08	neutral	-1.5	deleterious	-4.75	high_impact	4.41	0.85	neutral	0.6	neutral	4.27	23.90	deleterious	0.13	0.4	0.58	disease	0.86	disease	0.68	disease	0.56	disease	1	0.41	neutral	0.77	deleterious	-2	neutral	0.28	neutral	0.85	medium_impact	0.28	medium_impact	2.81	high_impact	0.66	0.8	19.47	16.72	0.6	P	0.40	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15016	15016	C	G	MI.8902	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	270	90	F	L	ttC/ttG	7.3	1	0	benign	0.02	neutral	0.56	neutral	3.08	neutral	-1.5	deleterious	-4.75	high_impact	4.41	0.85	neutral	0.6	neutral	3.98	23.60	deleterious	0.13	0.4	0.58	disease	0.86	disease	0.68	disease	0.56	disease	1	0.41	neutral	0.77	deleterious	-2	neutral	0.28	neutral	0.85	medium_impact	0.28	medium_impact	2.81	high_impact	0.66	0.8	19.47	16.72	0.6	P	0.40	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15017	15017	T	C	MI.8903	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	271	91	F	L	Ttt/Ctt	-1.88	0	0	benign	0.02	neutral	0.4	neutral	3.12	neutral	-1.14	deleterious	-5.18	high_impact	4.65	0.85	neutral	0.08	damaging	3.60	23.20	deleterious	0.08	0.35	0.42	neutral	0.87	disease	0.61	disease	0.68	disease	4	0.58	neutral	0.69	deleterious	-2	neutral	0.26	neutral	0.85	medium_impact	0.13	medium_impact	3.03	high_impact	0.50	0.8	57.63	8.71	0.45	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15017	15017	T	A	MI.8904	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	271	91	F	I	Ttt/Att	-1.88	0	0	benign	0.36	neutral	0.31	neutral	3.41	neutral	-0.34	deleterious	-5.18	high_impact	5.11	0.89	neutral	0.07	damaging	4.10	23.70	deleterious	0.07	0.35	0.65	disease	0.92	disease	0.67	disease	0.7	disease	4	0.63	neutral	0.48	deleterious	-2	neutral	0.60	deleterious	-0.5	medium_impact	0.03	medium_impact	3.45	high_impact	0.42	0.8	57.63	8.71	0.56	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15017	15017	T	G	MI.8905	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	271	91	F	V	Ttt/Gtt	-1.88	0	0	possibly_damaging	0.68	neutral	0.14	neutral	3.19	neutral	0.4	deleterious	-6.05	high_impact	4.76	0.84	neutral	0.08	damaging	3.81	23.40	deleterious	0.05	0.35	0.69	disease	0.92	disease	0.7	disease	0.71	disease	4	0.88	neutral	0.23	neutral	1	deleterious	0.65	deleterious	-1.04	low_impact	-0.21	medium_impact	3.13	high_impact	0.37	0.8	57.63	8.71	0.54	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15018	15018	T	C	MI.8906	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	272	91	F	S	tTt/tCt	5.69	1	0	probably_damaging	0.99	neutral	0.16	neutral	3.01	deleterious	-3.17	deleterious	-6.91	high_impact	5.11	0.86	neutral	0.06	damaging	4.15	23.80	deleterious	0.03	0.35	0.89	disease	0.9	disease	0.64	disease	0.62	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	-0.17	medium_impact	3.45	high_impact	0.37	0.8	57.63	8.71	0.7	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15018	15018	T	G	MI.8907	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	272	91	F	C	tTt/tGt	5.69	1	0	probably_damaging	0.99	neutral	0.1	neutral	2.98	deleterious	-4.44	deleterious	-6.92	high_impact	5.46	0.87	neutral	0.06	damaging	4.01	23.60	deleterious	0.03	0.35	0.94	disease	0.91	disease	0.69	disease	0.61	disease	2	0.99	deleterious	0.06	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	-0.3	medium_impact	3.76	high_impact	0.32	0.8	57.63	8.71	0.67	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15018	15018	T	A	MI.8908	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	272	91	F	Y	tTt/tAt	5.69	1	0	possibly_damaging	0.72	neutral	0.32	neutral	2.99	deleterious	-3.49	deleterious	-2.59	high_impact	5.11	0.91	neutral	0.07	damaging	3.89	23.50	deleterious	0.1	0.4	0.69	disease	0.88	disease	0.62	disease	0.68	disease	4	0.77	neutral	0.3	neutral	1	deleterious	0.74	deleterious	-1.11	low_impact	0.05	medium_impact	3.45	high_impact	0.48	0.8	57.63	8.71	0.75	P	0.87	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15019	15019	T	A	MI.8909	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	273	91	F	L	ttT/ttA	5.69	1	0	benign	0.02	neutral	0.4	neutral	3.12	neutral	-1.14	deleterious	-5.18	high_impact	4.65	0.85	neutral	0.08	damaging	4.12	23.80	deleterious	0.08	0.35	0.42	neutral	0.87	disease	0.61	disease	0.68	disease	4	0.58	neutral	0.69	deleterious	-2	neutral	0.26	neutral	0.85	medium_impact	0.13	medium_impact	3.03	high_impact	0.50	0.8	57.63	8.71	0.58	P	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8945	8945	T	A	MI.891	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	419	140	M	K	aTa/aAa	1.98	0.58	0	probably_damaging	0.94	deleterious	0	neutral	4.35	neutral	-1.39	deleterious	-4.25	medium_impact	2.4	0.83	neutral	0.39	neutral	3.96	23.60	deleterious	0.16	0.65	0.9	disease	0.64	disease	0.7	disease	0.75	disease	5	1	deleterious	0.03	neutral	5	deleterious	0.82	deleterious	-1.89	low_impact	-1.4	low_impact	0.96	medium_impact	0.52	0.9	44.25	8.21	0.28	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15019	15019	T	G	MI.8910	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	273	91	F	L	ttT/ttG	5.69	1	0	benign	0.02	neutral	0.4	neutral	3.12	neutral	-1.14	deleterious	-5.18	high_impact	4.65	0.85	neutral	0.08	damaging	4.00	23.60	deleterious	0.08	0.35	0.42	neutral	0.87	disease	0.61	disease	0.68	disease	4	0.58	neutral	0.69	deleterious	-2	neutral	0.26	neutral	0.85	medium_impact	0.13	medium_impact	3.03	high_impact	0.50	0.8	57.63	8.71	0.58	P	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15020	15020	A	C	MI.8911	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	274	92	I	L	Atc/Ctc	-1.65	0	0	probably_damaging	0.95	neutral	0.48	neutral	2.96	neutral	-1.95	neutral	-1.5	medium_impact	2.17	0.86	neutral	0.68	neutral	1.80	15.01	deleterious	0.16	0.45	0.31	neutral	0.7	disease	0.39	neutral	0.17	neutral	7	0.95	neutral	0.27	neutral	1	deleterious	0.58	deleterious	-1.92	low_impact	0.2	medium_impact	0.78	medium_impact	0.43	0.8	23.42	22.23	0.26	N	0.65	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15020	15020	A	T	MI.8912	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	274	92	I	F	Atc/Ttc	-1.65	0	0	probably_damaging	0.99	neutral	1	neutral	2.84	neutral	-1.24	deleterious	-2.99	medium_impact	3.02	0.83	neutral	0.58	neutral	2.07	16.67	deleterious	0.09	0.35	0.47	neutral	0.86	disease	0.55	disease	0.49	neutral	0	0.99	deleterious	0.51	deleterious	1	deleterious	0.78	deleterious	-2.59	low_impact	1.85	high_impact	1.55	medium_impact	0.56	0.8	23.42	22.23	0.19	N	0.95	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15020	15020	A	G	MI.8913	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	274	92	I	V	Atc/Gtc	-1.65	0	0	possibly_damaging	0.88	neutral	0.31	neutral	2.99	neutral	-1.97	neutral	-0.79	medium_impact	2.38	0.96	neutral	0.8	neutral	1.04	10.89	neutral	0.18	0.45	0.43	neutral	0.52	disease	0.43	neutral	0.17	neutral	7	0.89	neutral	0.22	neutral	0	NA	0.55	deleterious	-1.54	low_impact	0.03	medium_impact	0.97	medium_impact	0.40	0.8	23.42	22.23	0.39	N	0.51	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15021	15021	T	G	MI.8914	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	275	92	I	S	aTc/aGc	4.54	0.99	0	probably_damaging	1	neutral	0.36	neutral	2.83	neutral	-1.18	deleterious	-4.88	high_impact	4.46	0.84	neutral	0.37	neutral	3.89	23.50	deleterious	0.02	0.35	0.75	disease	0.88	disease	0.62	disease	0.67	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.09	medium_impact	2.86	high_impact	0.30	0.8	23.42	22.23	0.57	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15021	15021	T	A	MI.8915	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	275	92	I	N	aTc/aAc	4.54	0.99	0	probably_damaging	1	neutral	0.22	neutral	2.8	deleterious	-4.53	deleterious	-5.75	high_impact	4.59	0.86	neutral	0.39	neutral	4.12	23.80	deleterious	0.04	0.35	0.86	disease	0.88	disease	0.62	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.08	medium_impact	2.97	high_impact	0.35	0.8	23.42	22.23	0.61	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15021	15021	T	C	MI.8916	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	275	92	I	T	aTc/aCc	4.54	0.99	0	probably_damaging	1	neutral	0.23	neutral	2.84	deleterious	-3.16	deleterious	-4.06	high_impact	4.59	0.82	neutral	0.5	neutral	2.91	21.90	deleterious	0.03	0.35	0.68	disease	0.82	disease	0.56	disease	0.63	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.06	medium_impact	2.97	high_impact	0.21	0.8	23.42	22.23	0.61	P	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15022	15022	C	G	MI.8917	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	276	92	I	M	atC/atG	3.63	0.99	0.01	probably_damaging	1	neutral	0.22	neutral	2.87	deleterious	-3.55	neutral	-2.17	medium_impact	2.4	0.88	neutral	0.82	neutral	1.71	14.44	neutral	0.11	0.4	0.38	neutral	0.59	disease	0.52	disease	0.19	neutral	6	1	deleterious	0.11	neutral	1	deleterious	0.69	deleterious	-3.53	low_impact	-0.08	medium_impact	0.99	medium_impact	0.47	0.8	23.42	22.23	0.5	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15022	15022	C	A	MI.8918	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	276	92	I	M	atC/atA	3.63	0.99	0.01	probably_damaging	1	neutral	0.22	neutral	2.87	deleterious	-3.55	neutral	-2.17	medium_impact	2.4	0.88	neutral	0.82	neutral	2.06	16.60	deleterious	0.11	0.4	0.38	neutral	0.59	disease	0.52	disease	0.19	neutral	6	1	deleterious	0.11	neutral	1	deleterious	0.69	deleterious	-3.53	low_impact	-0.08	medium_impact	0.99	medium_impact	0.47	0.8	23.42	22.23	0.51	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15023	15023	T	A	MI.8919	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	277	93	C	S	Tgc/Agc	-3.49	0	0	probably_damaging	1	neutral	0.47	neutral	3.19	neutral	-0.94	deleterious	-8.57	high_impact	3.58	0.83	neutral	0.46	neutral	3.37	22.90	deleterious	0.06	0.35	0.6	disease	0.92	disease	0.61	disease	0.59	disease	2	1	deleterious	0.24	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.19	medium_impact	2.06	high_impact	0.48	0.8	57.63	8.31	0.32	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8946	8946	A	C	MI.892	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	420	140	M	I	atA/atC	2.44	0.6	0	probably_damaging	0.91	neutral	0.33	neutral	4.45	neutral	0.89	neutral	-1.4	neutral_impact	-0.52	0.86	neutral	0.57	neutral	1.89	15.52	deleterious	0.38	0.65	0.3	neutral	0.19	neutral	0.33	neutral	0.32	neutral	4	0.92	neutral	0.21	neutral	-2	neutral	0.60	deleterious	-1.71	low_impact	0.12	medium_impact	-1.54	low_impact	0.70	0.9	44.25	8.21	0.32	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15023	15023	T	G	MI.8920	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	277	93	C	G	Tgc/Ggc	-3.49	0	0	probably_damaging	1	neutral	0.54	neutral	3.12	deleterious	-3.46	deleterious	-10.33	high_impact	4.13	0.83	neutral	0.47	neutral	3.19	22.70	deleterious	0.05	0.35	0.73	disease	0.94	disease	0.66	disease	0.75	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.26	medium_impact	2.56	high_impact	0.41	0.8	57.63	8.31	0.38	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15023	15023	T	C	MI.8921	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	277	93	C	R	Tgc/Cgc	-3.49	0	0	probably_damaging	1	neutral	0.3	neutral	3.11	deleterious	-3.35	deleterious	-10.34	high_impact	5.17	0.84	neutral	0.36	neutral	3.39	23.00	deleterious	0.04	0.35	0.73	disease	0.97	disease	0.76	disease	0.79	disease	6	1	deleterious	0.15	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.02	medium_impact	3.5	high_impact	0.13	0.8	57.63	8.31	0.67	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15024	15024	G	A	MI.8922	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	278	93	C	Y	tGc/tAc	5.69	1	0.01	probably_damaging	1	neutral	1	neutral	3.12	deleterious	-3.08	deleterious	-9.46	high_impact	4.82	0.77	neutral	0.41	neutral	3.49	23.10	deleterious	0.06	0.35	0.66	disease	0.97	disease	0.69	disease	0.77	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.87	deleterious	-3.53	low_impact	1.85	high_impact	3.18	high_impact	0.35	0.8	57.63	8.31	0.63	P	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	G15024A	Possible DEAF modifier	+	-	Reported	1	.	P	P	damaging
chrM	15024	15024	G	C	MI.8923	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	278	93	C	S	tGc/tCc	5.69	1	0.01	probably_damaging	1	neutral	0.47	neutral	3.19	neutral	-0.94	deleterious	-8.57	high_impact	3.58	0.83	neutral	0.46	neutral	3.07	22.40	deleterious	0.06	0.35	0.6	disease	0.92	disease	0.61	disease	0.59	disease	2	1	deleterious	0.24	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.19	medium_impact	2.06	high_impact	0.48	0.8	57.63	8.31	0.5	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15024	15024	G	T	MI.8924	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	278	93	C	F	tGc/tTc	5.69	1	0.01	probably_damaging	1	neutral	0.98	neutral	3.2	neutral	-2.63	deleterious	-9.46	medium_impact	2.25	0.91	neutral	0.54	neutral	3.76	23.30	deleterious	0.05	0.35	0.27	neutral	0.97	disease	0.63	disease	0.61	disease	2	1	deleterious	0.49	deleterious	1	deleterious	0.83	deleterious	-3.53	low_impact	1.14	medium_impact	0.85	medium_impact	0.33	0.8	57.63	8.31	0.43	N	0.66	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15025	15025	C	G	MI.8925	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	279	93	C	W	tgC/tgG	5	1	0	probably_damaging	1	neutral	0.14	neutral	3.1	neutral	-2.74	deleterious	-9.47	high_impact	4.62	0.84	neutral	0.38	neutral	4.24	23.90	deleterious	0.04	0.35	0.85	disease	0.96	disease	0.73	disease	0.67	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.21	medium_impact	3	high_impact	0.24	0.8	57.63	8.31	0.61	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15025	15025	C	A	MI.8926	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	279	93	C	W	tgC/tgA	5	1	0	probably_damaging	1	neutral	0.14	neutral	3.1	neutral	-2.74	deleterious	-9.47	high_impact	4.62	0.84	neutral	0.38	neutral	4.57	24.40	deleterious	0.04	0.35	0.85	disease	0.96	disease	0.73	disease	0.67	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.21	medium_impact	3	high_impact	0.24	0.8	57.63	8.31	0.61	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15026	15026	C	G	MI.8927	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	280	94	L	V	Ctc/Gtc	-1.42	0	0	probably_damaging	0.99	neutral	0.35	neutral	3.17	neutral	1.28	neutral	-0.21	low_impact	1.52	0.91	neutral	0.11	damaging	3.07	22.40	deleterious	0.14	0.4	0.18	neutral	0.72	disease	0.36	neutral	0.2	neutral	6	0.99	deleterious	0.18	neutral	-2	neutral	0.68	deleterious	-2.59	low_impact	0.08	medium_impact	0.19	medium_impact	0.55	0.8	56.84	8.43	0.3	N	0.91	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15026	15026	C	A	MI.8928	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	280	94	L	I	Ctc/Atc	-1.42	0	0	probably_damaging	1	neutral	0.57	neutral	3.2	neutral	0.51	neutral	0.63	neutral_impact	-0.02	0.89	neutral	0.13	damaging	2.24	17.80	deleterious	0.15	0.45	0.27	neutral	0.1	neutral	0.25	neutral	0.29	neutral	4	1	deleterious	0.29	neutral	-2	neutral	0.65	deleterious	-3.53	low_impact	0.29	medium_impact	-1.21	low_impact	0.43	0.8	56.84	8.43	0.31	N	0.86	polymorphism	1	0.01	rs879178244	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15026	15026	C	T	MI.8929	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	280	94	L	F	Ctc/Ttc	-1.42	0	0	probably_damaging	1	neutral	0.83	neutral	3	deleterious	-3.21	neutral	-2.29	high_impact	3.7	0.88	neutral	0.09	damaging	3.90	23.50	deleterious	0.07	0.35	0.63	disease	0.84	disease	0.59	disease	0.7	disease	4	1	deleterious	0.42	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.6	medium_impact	2.17	high_impact	0.58	0.8	56.84	8.43	0.2	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8946	8946	A	T	MI.893	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	420	140	M	I	atA/atT	2.44	0.6	0	probably_damaging	0.91	neutral	0.33	neutral	4.45	neutral	0.89	neutral	-1.4	neutral_impact	-0.52	0.86	neutral	0.57	neutral	1.95	15.91	deleterious	0.38	0.65	0.3	neutral	0.19	neutral	0.33	neutral	0.32	neutral	4	0.92	neutral	0.21	neutral	-2	neutral	0.60	deleterious	-1.71	low_impact	0.12	medium_impact	-1.54	low_impact	0.70	0.9	44.25	8.21	0.33	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15027	15027	T	A	MI.8930	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	281	94	L	H	cTc/cAc	-0.5	0	0	probably_damaging	1	neutral	0.44	neutral	2.96	deleterious	-4.99	deleterious	-4.89	high_impact	4.5	0.85	neutral	0.07	damaging	4.04	23.70	deleterious	0.02	0.35	0.86	disease	0.87	disease	0.67	disease	0.66	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.17	medium_impact	2.89	high_impact	0.31	0.8	56.84	8.43	0.42	N	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15027	15027	T	G	MI.8931	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	281	94	L	R	cTc/cGc	-0.5	0	0	probably_damaging	1	neutral	0.27	neutral	2.97	deleterious	-4.39	deleterious	-4.61	high_impact	4.5	0.87	neutral	0.06	damaging	4.12	23.80	deleterious	0.01	0.35	0.81	disease	0.95	disease	0.7	disease	0.76	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.01	medium_impact	2.89	high_impact	0.22	0.8	56.84	8.43	0.43	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15027	15027	T	C	MI.8932	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	281	94	L	P	cTc/cCc	-0.5	0	0	probably_damaging	1	neutral	0.18	neutral	2.96	deleterious	-4.86	deleterious	-4.88	high_impact	4.5	0.87	neutral	0.06	damaging	3.80	23.40	deleterious	0.01	0.35	0.85	disease	0.94	disease	0.71	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	2.89	high_impact	0.43	0.8	56.84	8.43	0.43	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15029	15029	T	C	MI.8933	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	283	95	F	L	Ttc/Ctc	-4.17	0	0	benign	0.26	neutral	0.6	neutral	3.25	neutral	1.5	deleterious	-3.78	medium_impact	2.56	0.93	neutral	0.46	neutral	2.26	17.90	deleterious	0.11	0.4	0.71	disease	0.82	disease	0.61	disease	0.73	disease	5	0.29	neutral	0.67	deleterious	-3	neutral	0.57	deleterious	-0.31	medium_impact	0.32	medium_impact	1.13	medium_impact	0.42	0.8	57.37	9.26	0.27	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15029	15029	T	A	MI.8934	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	283	95	F	I	Ttc/Atc	-4.17	0	0	possibly_damaging	0.44	neutral	0.65	neutral	3.19	neutral	2.92	deleterious	-3.78	medium_impact	2.75	0.94	neutral	0.49	neutral	3.95	23.60	deleterious	0.1	0.4	0.85	disease	0.84	disease	0.62	disease	0.72	disease	4	0.36	neutral	0.61	deleterious	0	NA	0.67	deleterious	-0.63	medium_impact	0.37	medium_impact	1.3	medium_impact	0.37	0.8	57.37	9.26	0.28	N	0.81	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15029	15029	T	G	MI.8935	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	283	95	F	V	Ttc/Gtc	-4.17	0	0	possibly_damaging	0.56	neutral	0.31	neutral	3.18	neutral	3.12	deleterious	-3.93	medium_impact	3.45	0.95	neutral	0.56	neutral	3.77	23.40	deleterious	0.08	0.35	0.84	disease	0.89	disease	0.64	disease	0.7	disease	4	0.69	neutral	0.38	neutral	0	NA	0.68	deleterious	-0.83	medium_impact	0.03	medium_impact	1.94	medium_impact	0.27	0.8	57.37	9.26	0.38	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15030	15030	T	C	MI.8936	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	284	95	F	S	tTc/tCc	5.69	0.87	0	benign	0.05	neutral	0.27	neutral	3.1	neutral	-0.53	deleterious	-4.8	medium_impact	3.45	0.96	neutral	0.63	neutral	3.99	23.60	deleterious	0.04	0.35	0.87	disease	0.81	disease	0.63	disease	0.71	disease	4	0.71	neutral	0.61	deleterious	-3	neutral	0.35	neutral	0.46	medium_impact	-0.01	medium_impact	1.94	medium_impact	0.23	0.8	57.37	9.26	0.49	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15030	15030	T	A	MI.8937	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	284	95	F	Y	tTc/tAc	5.69	0.87	0	possibly_damaging	0.52	neutral	1	neutral	3.41	neutral	3.17	neutral	2.46	neutral_impact	-1.88	0.97	neutral	0.81	neutral	-0.21	1.05	neutral	0.13	0.4	0.14	neutral	0.12	neutral	0.39	neutral	0.26	neutral	5	0.52	neutral	0.74	deleterious	-3	neutral	0.49	deleterious	-0.76	medium_impact	1.85	high_impact	-2.9	low_impact	0.48	0.8	57.37	9.26	0.45	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15030	15030	T	G	MI.8938	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	284	95	F	C	tTc/tGc	5.69	0.87	0	probably_damaging	0.93	neutral	0.15	neutral	3.07	neutral	-1.65	deleterious	-4.81	medium_impact	3.45	0.94	neutral	0.41	neutral	4.01	23.60	deleterious	0.04	0.35	0.94	disease	0.9	disease	0.66	disease	0.7	disease	4	0.96	neutral	0.11	neutral	1	deleterious	0.85	deleterious	-1.78	low_impact	-0.19	medium_impact	1.94	medium_impact	0.17	0.8	57.37	9.26	0.51	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15031	15031	C	G	MI.8939	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	285	95	F	L	ttC/ttG	-0.5	0	0	benign	0.26	neutral	0.6	neutral	3.25	neutral	1.5	deleterious	-3.78	medium_impact	2.56	0.93	neutral	0.46	neutral	2.63	20.40	deleterious	0.11	0.4	0.71	disease	0.82	disease	0.61	disease	0.73	disease	5	0.29	neutral	0.67	deleterious	-3	neutral	0.57	deleterious	-0.31	medium_impact	0.32	medium_impact	1.13	medium_impact	0.42	0.8	57.37	9.26	0.28	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8947	8947	C	A	MI.894	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	421	141	L	M	Cta/Ata	-1.95	0	0	probably_damaging	1	neutral	0.87	neutral	4.22	neutral	-1.91	neutral	-1.74	low_impact	1.79	0.6	neutral	0.17	damaging	3.70	23.30	deleterious	0.32	0.65	0.46	neutral	0.08	neutral	0.34	neutral	0.3	neutral	4	1	deleterious	0.44	neutral	-2	neutral	0.69	deleterious	-3.6	low_impact	0.76	medium_impact	0.44	medium_impact	0.75	0.9	46.46	8.22	0.26	N	0.96	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15031	15031	C	A	MI.8940	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	285	95	F	L	ttC/ttA	-0.5	0	0	benign	0.26	neutral	0.6	neutral	3.25	neutral	1.5	deleterious	-3.78	medium_impact	2.56	0.93	neutral	0.46	neutral	2.96	22.10	deleterious	0.11	0.4	0.71	disease	0.82	disease	0.61	disease	0.73	disease	5	0.29	neutral	0.67	deleterious	-3	neutral	0.57	deleterious	-0.31	medium_impact	0.32	medium_impact	1.13	medium_impact	0.42	0.8	57.37	9.26	0.28	N	0.85	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15032	15032	C	G	MI.8941	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	286	96	L	V	Cta/Gta	-3.03	0	0	probably_damaging	0.98	neutral	0.33	neutral	3.24	deleterious	-4.61	neutral	-1.88	medium_impact	3.13	0.93	neutral	0.42	neutral	1.65	14.15	neutral	0.18	0.45	0.56	disease	0.73	disease	0.39	neutral	0.36	neutral	3	0.98	neutral	0.18	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	0.06	medium_impact	1.65	medium_impact	0.53	0.8	15.26	27.57	0.36	N	0.69	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15032	15032	C	A	MI.8942	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	286	96	L	M	Cta/Ata	-3.03	0	0	probably_damaging	1	neutral	0.31	neutral	2.94	deleterious	-5.28	neutral	-0.66	low_impact	1.68	0.94	neutral	0.81	neutral	2.18	17.40	deleterious	0.18	0.45	0.37	neutral	0.34	neutral	0.35	neutral	0.44	neutral	1	1	deleterious	0.16	neutral	-2	neutral	0.68	deleterious	-3.53	low_impact	0.03	medium_impact	0.33	medium_impact	0.40	0.8	15.26	27.57	0.45	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15033	15033	T	C	MI.8943	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	287	96	L	P	cTa/cCa	-1.88	0	0	probably_damaging	1	neutral	0.1	neutral	2.9	deleterious	-7.5	deleterious	-5.07	high_impact	4.87	0.87	neutral	0.09	damaging	3.78	23.40	deleterious	0.02	0.35	0.93	disease	0.91	disease	0.7	disease	0.64	disease	3	1	deleterious	0.05	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.3	medium_impact	3.23	high_impact	0.33	0.8	15.26	27.57	0.62	P	0.93	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15033	15033	T	A	MI.8944	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	287	96	L	Q	cTa/cAa	-1.88	0	0	probably_damaging	1	neutral	0.14	neutral	2.9	deleterious	-6.8	deleterious	-4.09	high_impact	4.87	0.86	neutral	0.14	damaging	3.94	23.50	deleterious	0.02	0.35	0.91	disease	0.82	disease	0.58	disease	0.63	disease	3	1	deleterious	0.07	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.21	medium_impact	3.23	high_impact	0.30	0.8	15.26	27.57	0.66	P	0.91	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15033	15033	T	G	MI.8945	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	287	96	L	R	cTa/cGa	-1.88	0	0	probably_damaging	1	neutral	0.2	neutral	2.9	deleterious	-6.73	deleterious	-4.28	high_impact	4.87	0.87	neutral	0.09	damaging	4.06	23.70	deleterious	0.01	0.35	0.91	disease	0.93	disease	0.69	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.1	medium_impact	3.23	high_impact	0.24	0.8	15.26	27.57	0.66	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15035	15035	C	G	MI.8946	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	289	97	H	D	Cac/Gac	-20	0	0	probably_damaging	1	neutral	0.19	neutral	1.79	deleterious	-8.41	deleterious	-7.87	high_impact	5.47	0.84	neutral	0.08	damaging	3.63	23.20	deleterious	0.04	0.35	0.93	disease	0.9	disease	0.85	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.12	medium_impact	3.77	high_impact	0.27	0.8	56.84	8.72	0.59	P	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15035	15035	C	A	MI.8947	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	289	97	H	N	Cac/Aac	-20	0	0	probably_damaging	1	neutral	0.28	neutral	1.79	deleterious	-7.58	deleterious	-6.12	high_impact	5.47	0.85	neutral	0.1	damaging	3.50	23.10	deleterious	0.15	0.4	0.95	disease	0.88	disease	0.8	disease	0.64	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0	medium_impact	3.77	high_impact	0.39	0.8	56.84	8.72	0.64	P	0.97	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15035	15035	C	T	MI.8948	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	289	97	H	Y	Cac/Tac	-20	0	0	probably_damaging	1	neutral	1	neutral	1.78	deleterious	-7.46	deleterious	-5.25	high_impact	4.58	0.9	neutral	0.09	damaging	3.32	22.90	deleterious	0.09	0.35	0.92	disease	0.92	disease	0.83	disease	0.64	disease	3	1	deleterious	0.5	deleterious	2	deleterious	0.89	deleterious	-3.53	low_impact	1.85	high_impact	2.97	high_impact	0.28	0.8	56.84	8.72	0.43	N	1.00	polymorphism	1	0.22	.	.	.	.	.	.	COSM1138293	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15036	15036	A	G	MI.8949	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	290	97	H	R	cAc/cGc	5.46	1	0	probably_damaging	1	neutral	0.33	neutral	1.82	deleterious	-7.39	deleterious	-7	high_impact	5.47	0.86	neutral	0.07	damaging	2.52	19.61	deleterious	0.07	0.35	0.93	disease	0.92	disease	0.82	disease	0.64	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.06	medium_impact	3.77	high_impact	0.41	0.8	56.84	8.72	0.71	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8947	8947	C	G	MI.895	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	421	141	L	V	Cta/Gta	-1.95	0	0	probably_damaging	0.99	neutral	0.14	neutral	4.08	neutral	-1.45	deleterious	-2.53	medium_impact	3.14	0.58	damaging	0.16	damaging	3.44	23.00	deleterious	0.33	0.65	0.69	disease	0.5	neutral	0.66	disease	0.65	disease	3	0.99	deleterious	0.08	neutral	1	deleterious	0.77	deleterious	-2.65	low_impact	-0.15	medium_impact	1.59	medium_impact	0.68	0.9	46.46	8.22	0.31	N	0.87	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15036	15036	A	T	MI.8950	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	290	97	H	L	cAc/cTc	5.46	1	0	probably_damaging	1	neutral	0.73	neutral	1.79	deleterious	-8.16	deleterious	-9.62	high_impact	5.12	0.88	neutral	0.08	damaging	3.35	22.90	deleterious	0.03	0.35	0.94	disease	0.94	disease	0.8	disease	0.64	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.46	medium_impact	3.46	high_impact	0.19	0.8	56.84	8.72	0.68	P	0.92	polymorphism	1	0.22	.	.	.	.	.	.	COSM6716230	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15036	15036	A	C	MI.8951	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	290	97	H	P	cAc/cCc	5.46	1	0	probably_damaging	1	neutral	0.18	neutral	1.77	deleterious	-9.08	deleterious	-8.75	high_impact	5.47	0.9	neutral	0.07	damaging	2.99	22.20	deleterious	0.03	0.35	0.96	disease	0.91	disease	0.87	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.77	high_impact	0.23	0.8	56.84	8.72	0.65	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15037	15037	C	A	MI.8952	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	291	97	H	Q	caC/caA	6.84	1	0	probably_damaging	1	neutral	0.27	neutral	1.82	deleterious	-6.38	deleterious	-7	high_impact	5.47	0.88	neutral	0.08	damaging	3.60	23.20	deleterious	0.09	0.4	0.95	disease	0.85	disease	0.8	disease	0.69	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.01	medium_impact	3.77	high_impact	0.44	0.8	56.84	8.72	0.71	P	0.94	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15037	15037	C	G	MI.8953	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	291	97	H	Q	caC/caG	6.84	1	0	probably_damaging	1	neutral	0.27	neutral	1.82	deleterious	-6.38	deleterious	-7	high_impact	5.47	0.88	neutral	0.08	damaging	3.18	22.70	deleterious	0.09	0.4	0.95	disease	0.85	disease	0.8	disease	0.69	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.01	medium_impact	3.77	high_impact	0.44	0.8	56.84	8.72	0.71	P	0.94	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15038	15038	A	C	MI.8954	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	292	98	I	L	Atc/Ctc	-2.34	0	0.02	probably_damaging	0.95	neutral	0.65	neutral	3.3	neutral	0.31	neutral	-1.68	high_impact	3.7	0.84	neutral	0.52	neutral	1.71	14.45	neutral	0.24	0.45	0.43	neutral	0.81	disease	0.5	neutral	0.64	disease	3	0.94	neutral	0.35	neutral	2	deleterious	0.67	deleterious	-1.92	low_impact	0.37	medium_impact	2.17	high_impact	0.54	0.8	16.32	19.7	0.25	N	0.63	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15038	15038	A	G	MI.8955	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	292	98	I	V	Atc/Gtc	-2.34	0	0.02	possibly_damaging	0.88	neutral	0.5	neutral	3.15	neutral	-0.56	neutral	-0.55	low_impact	1.74	0.97	neutral	0.97	neutral	-1.49	0.00	neutral	0.28	0.45	0.2	neutral	0.23	neutral	0.4	neutral	0.36	neutral	3	0.86	neutral	0.31	neutral	-3	neutral	0.54	deleterious	-1.54	low_impact	0.22	medium_impact	0.39	medium_impact	0.43	0.8	16.32	19.7	0.4	N	0.00	polymorphism	1	0.01	rs202045169	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15038	15038	A	T	MI.8956	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	292	98	I	F	Atc/Ttc	-2.34	0	0.02	probably_damaging	0.99	neutral	0.71	neutral	3.05	neutral	-1.98	deleterious	-3.41	high_impact	4.16	0.85	neutral	0.57	neutral	1.96	15.95	deleterious	0.09	0.35	0.76	disease	0.88	disease	0.63	disease	0.69	disease	4	0.99	deleterious	0.36	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	0.43	medium_impact	2.58	high_impact	0.56	0.8	16.32	19.7	0.28	N	0.93	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15039	15039	T	G	MI.8957	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	293	98	I	S	aTc/aGc	0.41	0.02	0	probably_damaging	1	neutral	0.4	neutral	3.01	neutral	-2.21	deleterious	-4.92	high_impact	5.2	0.84	neutral	0.53	neutral	3.94	23.50	deleterious	0.02	0.35	0.85	disease	0.88	disease	0.6	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.13	medium_impact	3.53	high_impact	0.25	0.8	16.32	19.7	0.68	P	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15039	15039	T	C	MI.8958	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	293	98	I	T	aTc/aCc	0.41	0.02	0	probably_damaging	1	neutral	0.39	neutral	3.03	neutral	-1.58	deleterious	-3.86	high_impact	3.75	0.77	neutral	0.65	neutral	2.91	21.90	deleterious	0.06	0.35	0.74	disease	0.81	disease	0.56	disease	0.62	disease	2	1	deleterious	0.2	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.12	medium_impact	2.21	high_impact	0.26	0.8	16.32	19.7	0.35	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15039	15039	T	A	MI.8959	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	293	98	I	N	aTc/aAc	0.41	0.02	0	probably_damaging	1	neutral	0.3	neutral	2.99	deleterious	-3.48	deleterious	-5.8	high_impact	5.2	0.83	neutral	0.55	neutral	4.18	23.80	deleterious	0.06	0.35	0.91	disease	0.9	disease	0.63	disease	0.66	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.02	medium_impact	3.53	high_impact	0.35	0.8	16.32	19.7	0.66	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8948	8948	T	A	MI.896	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	422	141	L	Q	cTa/cAa	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	4.02	deleterious	-5.02	deleterious	-5.29	high_impact	4.38	0.47	damaging	0.15	damaging	4.39	24.10	deleterious	0.18	0.65	0.9	disease	0.66	disease	0.67	disease	0.73	disease	5	1	deleterious	0	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-1.4	low_impact	2.66	high_impact	0.70	0.9	46.46	8.22	0.41	N	0.98	polymorphism	0.61	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15040	15040	C	G	MI.8960	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	294	98	I	M	atC/atG	4.54	0.67	0.01	probably_damaging	1	neutral	0.22	neutral	3.45	neutral	1.79	neutral	-2.36	medium_impact	2.58	0.81	neutral	0.68	neutral	2.81	21.40	deleterious	0.15	0.45	0.3	neutral	0.72	disease	0.36	neutral	0.37	neutral	3	1	deleterious	0.11	neutral	1	deleterious	0.69	deleterious	-3.53	low_impact	-0.08	medium_impact	1.15	medium_impact	0.57	0.8	16.32	19.7	0.34	N	0.78	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15040	15040	C	A	MI.8961	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	294	98	I	M	atC/atA	4.54	0.67	0.01	probably_damaging	1	neutral	0.22	neutral	3.45	neutral	1.79	neutral	-2.36	medium_impact	2.58	0.81	neutral	0.68	neutral	3.32	22.90	deleterious	0.15	0.45	0.3	neutral	0.72	disease	0.36	neutral	0.37	neutral	3	1	deleterious	0.11	neutral	1	deleterious	0.69	deleterious	-3.53	low_impact	-0.08	medium_impact	1.15	medium_impact	0.57	0.8	16.32	19.7	0.34	N	0.78	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15041	15041	G	C	MI.8962	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	295	99	G	R	Ggg/Cgg	-4.86	0	0	probably_damaging	1	neutral	0.36	neutral	3.12	neutral	-1.63	deleterious	-5.81	high_impact	4.82	0.9	neutral	0.22	damaging	3.88	23.50	deleterious	0.03	0.35	0.61	disease	0.94	disease	0.75	disease	0.8	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.09	medium_impact	3.18	high_impact	0.43	0.8	56.32	8.65	0.67	P	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15041	15041	G	T	MI.8963	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	295	99	G	W	Ggg/Tgg	-4.86	0	0	probably_damaging	1	neutral	0.17	neutral	3.1	deleterious	-3	deleterious	-6.16	high_impact	4.36	0.89	neutral	0.24	damaging	4.34	24.00	deleterious	0.04	0.35	0.83	disease	0.94	disease	0.7	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.15	medium_impact	2.77	high_impact	0.12	0.8	56.32	8.65	0.46	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15042	15042	G	A	MI.8964	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	296	99	G	E	gGg/gAg	5.92	1	0	probably_damaging	1	neutral	0.25	neutral	3.11	neutral	-1.96	deleterious	-5.8	high_impact	5.17	0.86	neutral	0.3	neutral	3.85	23.40	deleterious	0.03	0.35	0.58	disease	0.91	disease	0.75	disease	0.71	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.04	medium_impact	3.5	high_impact	0.23	0.8	56.32	8.65	0.65	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15042	15042	G	C	MI.8965	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	296	99	G	A	gGg/gCg	5.92	1	0	probably_damaging	1	neutral	0.49	neutral	3.28	neutral	0.92	deleterious	-3.53	low_impact	1.55	0.9	neutral	0.43	neutral	1.94	15.81	deleterious	0.09	0.35	0.21	neutral	0.54	disease	0.33	neutral	0.18	neutral	6	1	deleterious	0.25	neutral	-2	neutral	0.72	deleterious	-3.53	low_impact	0.21	medium_impact	0.21	medium_impact	0.42	0.8	56.32	8.65	0.53	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15042	15042	G	T	MI.8966	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	296	99	G	V	gGg/gTg	5.92	1	0	probably_damaging	1	neutral	0.5	neutral	3.21	neutral	0.84	deleterious	-6.34	high_impact	4.47	0.91	neutral	0.35	neutral	3.75	23.30	deleterious	0.03	0.35	0.37	neutral	0.93	disease	0.64	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.22	medium_impact	2.87	high_impact	0.18	0.8	56.32	8.65	0.54	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15044	15044	C	T	MI.8967	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	298	100	R	W	Cga/Tga	-8.3	0	0	probably_damaging	1	neutral	0.18	neutral	2.44	deleterious	-7.5	deleterious	-6.99	high_impact	4.89	0.82	neutral	0.2	damaging	5.18	25.50	deleterious	0.09	0.35	0.65	disease	0.92	disease	0.74	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.14	medium_impact	3.25	high_impact	0.80	0.85	57.37	8.76	0.59	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15044	15044	C	G	MI.8968	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	298	100	R	G	Cga/Gga	-8.3	0	0	probably_damaging	1	neutral	0.34	neutral	2.48	deleterious	-5.6	deleterious	-6.11	high_impact	4.29	0.81	neutral	0.34	neutral	4.00	23.60	deleterious	0.06	0.35	0.78	disease	0.84	disease	0.78	disease	0.68	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.07	medium_impact	2.7	high_impact	0.25	0.8	57.37	8.76	0.45	N	0.99	polymorphism	1	0.18	rs879127956	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15045	15045	G	T	MI.8969	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	299	100	R	L	cGa/cTa	2.71	0.98	0	probably_damaging	1	neutral	0.65	neutral	2.47	deleterious	-4.3	deleterious	-6.11	high_impact	5.09	0.82	neutral	0.27	damaging	4.06	23.70	deleterious	0.07	0.35	0.72	disease	0.95	disease	0.77	disease	0.79	disease	6	1	deleterious	0.33	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.37	medium_impact	3.43	high_impact	0.06	0.8	57.37	8.76	0.68	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8948	8948	T	G	MI.897	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	422	141	L	R	cTa/cGa	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	4.05	deleterious	-4.85	deleterious	-5.29	high_impact	4.38	0.38	damaging	0.13	damaging	4.23	23.90	deleterious	0.14	0.65	0.89	disease	0.81	disease	0.77	disease	0.81	disease	6	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.66	high_impact	0.51	0.9	46.46	8.22	0.63	P	0.99	polymorphism	0.56	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15045	15045	G	A	MI.8970	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	299	100	R	Q	cGa/cAa	2.71	0.98	0	probably_damaging	1	neutral	0.29	neutral	2.57	deleterious	-4.32	deleterious	-3.46	high_impact	4.75	0.75	neutral	0.23	damaging	4.27	24.00	deleterious	0.16	0.45	0.59	disease	0.84	disease	0.8	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.01	medium_impact	3.12	high_impact	0.72	0.85	57.37	8.76	0.79	P	1.00	polymorphism	1	0.05	.	.	.	.	.	.	COSM1138294	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15045	15045	G	C	MI.8971	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	299	100	R	P	cGa/cCa	2.71	0.98	0	probably_damaging	1	neutral	0.2	neutral	2.46	deleterious	-5.67	deleterious	-6.11	high_impact	5.44	0.82	neutral	0.2	damaging	4.19	23.80	deleterious	0.03	0.35	0.82	disease	0.9	disease	0.81	disease	0.68	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.1	medium_impact	3.75	high_impact	0.17	0.8	57.37	8.76	0.7	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15047	15047	G	C	MI.8972	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	301	101	G	R	Ggc/Cgc	0.18	0.96	0.01	probably_damaging	1	neutral	0.37	neutral	3.12	deleterious	-3.29	deleterious	-6.98	high_impact	5.39	0.9	neutral	0.22	damaging	3.94	23.50	deleterious	0.02	0.35	0.94	disease	0.92	disease	0.76	disease	0.6	disease	2	1	deleterious	0.19	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	0.1	medium_impact	3.7	high_impact	0.50	0.8	31.58	9.28	0.65	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15047	15047	G	A	MI.8973	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	301	101	G	S	Ggc/Agc	0.18	0.96	0.01	possibly_damaging	0.48	neutral	0.41	neutral	3.14	neutral	-2.32	deleterious	-5.21	medium_impact	3.48	0.9	neutral	0.44	neutral	4.09	23.70	deleterious	0.05	0.35	0.78	disease	0.85	disease	0.6	disease	0.66	disease	3	0.56	neutral	0.47	neutral	0	NA	0.52	deleterious	-0.7	medium_impact	0.14	medium_impact	1.97	medium_impact	0.60	0.8	31.58	9.28	0.47	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15047	15047	G	T	MI.8974	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	301	101	G	C	Ggc/Tgc	0.18	0.96	0.01	probably_damaging	1	neutral	0.17	neutral	3.07	deleterious	-3.94	deleterious	-7.86	high_impact	5.05	0.91	neutral	0.22	damaging	4.16	23.80	deleterious	0.03	0.35	0.95	disease	0.92	disease	0.7	disease	0.61	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.15	medium_impact	3.39	high_impact	0.14	0.8	31.58	9.28	0.62	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15048	15048	G	T	MI.8975	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	302	101	G	V	gGc/gTc	5	1	0	probably_damaging	1	neutral	0.5	neutral	3.21	neutral	0.45	deleterious	-7.86	high_impact	5.39	0.91	neutral	0.36	neutral	3.73	23.30	deleterious	0.03	0.35	0.91	disease	0.92	disease	0.69	disease	0.62	disease	2	1	deleterious	0.25	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.22	medium_impact	3.7	high_impact	0.15	0.8	31.58	9.28	0.67	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15048	15048	G	C	MI.8976	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	302	101	G	A	gGc/gCc	5	1	0	possibly_damaging	0.66	neutral	0.5	neutral	3.15	neutral	-1.71	deleterious	-5.23	high_impact	4.04	0.91	neutral	0.42	neutral	3.04	22.40	deleterious	0.05	0.35	0.77	disease	0.78	disease	0.68	disease	0.67	disease	3	0.64	neutral	0.42	neutral	1	deleterious	0.77	deleterious	-1	medium_impact	0.22	medium_impact	2.48	high_impact	0.40	0.8	31.58	9.28	0.58	P	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15048	15048	G	A	MI.8977	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	302	101	G	D	gGc/gAc	5	1	0	probably_damaging	0.99	neutral	0.2	neutral	3.11	deleterious	-3.97	deleterious	-6.1	high_impact	5.39	0.86	neutral	0.28	damaging	3.86	23.50	deleterious	0.03	0.35	0.9	disease	0.92	disease	0.79	disease	0.63	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-2.59	low_impact	-0.1	medium_impact	3.7	high_impact	0.11	0.8	31.58	9.28	0.71	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	COSM1138297	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15050	15050	C	G	MI.8978	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	304	102	L	V	Cta/Gta	-20	0	0	benign	0.32	neutral	0.5	neutral	3.1	neutral	-0.52	neutral	-1.95	medium_impact	3.35	0.97	neutral	0.74	neutral	2.94	22.00	deleterious	0.19	0.45	0.63	disease	0.63	disease	0.48	neutral	0.34	neutral	3	0.41	neutral	0.59	deleterious	-3	neutral	0.47	deleterious	-0.43	medium_impact	0.22	medium_impact	1.85	medium_impact	0.49	0.8	17.63	25.1	0.29	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15050	15050	C	A	MI.8979	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	304	102	L	M	Cta/Ata	-20	0	0	benign	0.32	neutral	0.22	neutral	3.01	neutral	-1.72	neutral	-1.34	medium_impact	2.09	0.96	neutral	0.88	neutral	2.37	18.62	deleterious	0.19	0.45	0.48	neutral	0.41	neutral	0.26	neutral	0.42	neutral	2	0.74	neutral	0.45	neutral	-3	neutral	0.35	neutral	-0.43	medium_impact	-0.08	medium_impact	0.7	medium_impact	0.52	0.8	17.63	25.1	0.43	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8948	8948	T	C	MI.898	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	422	141	L	P	cTa/cCa	0.13	0.01	0	probably_damaging	1	deleterious	0	neutral	4	deleterious	-5.42	deleterious	-6.18	high_impact	4.04	0.29	damaging	0.15	damaging	3.98	23.60	deleterious	0.19	0.65	0.92	disease	0.75	disease	0.77	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.36	high_impact	0.74	0.9	46.46	8.22	0.8	P	1.00	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15051	15051	T	G	MI.8980	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	305	102	L	R	cTa/cGa	-4.86	0	0	probably_damaging	0.94	neutral	0.35	neutral	2.96	deleterious	-3.63	deleterious	-4.9	high_impact	5.01	0.94	neutral	0.47	neutral	4.13	23.80	deleterious	0.01	0.35	0.94	disease	0.88	disease	0.72	disease	0.67	disease	3	0.94	neutral	0.21	neutral	2	deleterious	0.89	deleterious	-1.85	low_impact	0.08	medium_impact	3.36	high_impact	0.11	0.8	17.63	25.1	0.7	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15051	15051	T	A	MI.8981	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	305	102	L	Q	cTa/cAa	-4.86	0	0	probably_damaging	0.94	neutral	0.29	neutral	2.95	deleterious	-3.79	deleterious	-4.85	high_impact	5.01	0.94	neutral	0.51	neutral	4.00	23.60	deleterious	0.02	0.35	0.93	disease	0.77	disease	0.6	disease	0.68	disease	4	0.95	neutral	0.18	neutral	2	deleterious	0.83	deleterious	-1.85	low_impact	0.01	medium_impact	3.36	high_impact	0.21	0.8	17.63	25.1	0.65	P	0.89	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15051	15051	T	C	MI.8982	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	305	102	L	P	cTa/cCa	-4.86	0	0	probably_damaging	0.99	neutral	0.2	neutral	2.95	deleterious	-4.19	deleterious	-5.64	high_impact	5.01	0.93	neutral	0.35	neutral	3.87	23.50	deleterious	0.01	0.35	0.95	disease	0.86	disease	0.6	disease	0.67	disease	3	0.99	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-2.59	low_impact	-0.1	medium_impact	3.36	high_impact	0.18	0.8	17.63	25.1	0.64	P	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15053	15053	T	C	MI.8983	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	307	103	Y	H	Tat/Cat	-16.1	0	0	probably_damaging	1	neutral	0.47	neutral	3.01	deleterious	-4.06	deleterious	-4.39	high_impact	5.04	0.89	neutral	0.08	damaging	3.43	23.00	deleterious	0.07	0.35	0.83	disease	0.85	disease	0.82	disease	0.68	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.19	medium_impact	3.38	high_impact	0.15	0.8	58.95	8.74	0.73	P	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15053	15053	T	G	MI.8984	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	307	103	Y	D	Tat/Gat	-16.1	0	0	probably_damaging	1	neutral	0.17	neutral	3	deleterious	-4.75	deleterious	-8.77	high_impact	5.04	0.83	neutral	0.07	damaging	3.86	23.50	deleterious	0.03	0.35	0.95	disease	0.91	disease	0.82	disease	0.65	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.15	medium_impact	3.38	high_impact	0.12	0.8	58.95	8.74	0.63	P	1.00	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15053	15053	T	A	MI.8985	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	307	103	Y	N	Tat/Aat	-16.1	0	0	probably_damaging	1	neutral	0.29	neutral	3.02	deleterious	-3.48	deleterious	-7.89	high_impact	4.11	0.85	neutral	0.09	damaging	3.93	23.50	deleterious	0.05	0.35	0.66	disease	0.9	disease	0.75	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.01	medium_impact	2.54	high_impact	0.12	0.8	58.95	8.74	0.4	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15054	15054	A	T	MI.8986	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	308	103	Y	F	tAt/tTt	7.3	1	0	probably_damaging	1	neutral	0.61	neutral	3.41	neutral	0.61	deleterious	-3.49	medium_impact	2.92	0.91	neutral	0.08	damaging	2.87	21.70	deleterious	0.14	0.4	0.47	neutral	0.86	disease	0.63	disease	0.67	disease	3	1	deleterious	0.31	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.33	medium_impact	1.46	medium_impact	0.47	0.8	58.95	8.74	0.47	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15054	15054	A	G	MI.8987	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	308	103	Y	C	tAt/tGt	7.3	1	0	probably_damaging	1	neutral	0.15	neutral	3.02	deleterious	-3.94	deleterious	-7.89	high_impact	5.04	0.85	neutral	0.05	damaging	3.37	22.90	deleterious	0.03	0.35	0.96	disease	0.9	disease	0.78	disease	0.66	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.19	medium_impact	3.38	high_impact	0.16	0.8	58.95	8.74	0.69	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15054	15054	A	C	MI.8988	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	308	103	Y	S	tAt/tCt	7.3	1	0	probably_damaging	1	neutral	0.36	neutral	3.05	neutral	-2.49	deleterious	-7.89	high_impact	5.04	0.88	neutral	0.09	damaging	3.48	23.10	deleterious	0.04	0.35	0.9	disease	0.87	disease	0.74	disease	0.61	disease	2	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.09	medium_impact	3.38	high_impact	0.13	0.8	58.95	8.74	0.73	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15056	15056	T	C	MI.8989	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	310	104	Y	H	Tac/Cac	-3.03	0	0	probably_damaging	1	neutral	0.36	neutral	3.02	deleterious	-3.29	deleterious	-4.36	high_impact	4.53	0.9	neutral	0.08	damaging	3.51	23.10	deleterious	0.08	0.35	0.64	disease	0.84	disease	0.8	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.09	medium_impact	2.92	high_impact	0.33	0.8	58.16	8.8	0.55	N	0.98	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8950	8950	G	C	MI.899	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	424	142	V	L	Gtt/Ctt	-2.19	0	0.01	benign	0.01	neutral	0.2	neutral	4.38	neutral	-0.04	neutral	-1.66	medium_impact	2.79	0.8	neutral	0.53	neutral	1.64	14.06	neutral	0.36	0.65	0.42	neutral	0.59	disease	0.58	disease	0.67	disease	3	0.8	neutral	0.6	deleterious	-3	neutral	0.18	neutral	1.14	medium_impact	-0.05	medium_impact	1.29	medium_impact	0.57	0.9	11.95	13.75	0.36	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15056	15056	T	A	MI.8990	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	310	104	Y	N	Tac/Aac	-3.03	0	0	probably_damaging	1	neutral	0.19	neutral	3.02	neutral	-2.81	deleterious	-7.87	high_impact	4.22	0.86	neutral	0.09	damaging	4.12	23.80	deleterious	0.04	0.35	0.92	disease	0.9	disease	0.83	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.12	medium_impact	2.64	high_impact	0.24	0.8	58.16	8.8	0.47	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15056	15056	T	G	MI.8991	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	310	104	Y	D	Tac/Gac	-3.03	0	0	probably_damaging	1	neutral	0.12	neutral	3.03	neutral	-2.87	deleterious	-8.74	high_impact	5.42	0.84	neutral	0.07	damaging	3.87	23.50	deleterious	0.03	0.35	0.96	disease	0.9	disease	0.87	disease	0.69	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.25	medium_impact	3.73	high_impact	0.15	0.8	58.16	8.8	0.67	P	1.00	disease_causing	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15057	15057	A	T	MI.8992	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	311	104	Y	F	tAc/tTc	7.3	1	0	probably_damaging	1	neutral	0.42	neutral	3.09	neutral	-2.17	deleterious	-3.47	medium_impact	3.25	0.91	neutral	0.08	damaging	3.06	22.40	deleterious	0.14	0.4	0.42	neutral	0.84	disease	0.74	disease	0.57	disease	1	1	deleterious	0.21	neutral	1	deleterious	0.82	deleterious	-3.53	low_impact	0.15	medium_impact	1.76	medium_impact	0.56	0.8	58.16	8.8	0.57	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15057	15057	A	G	MI.8993	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	311	104	Y	C	tAc/tGc	7.3	1	0	probably_damaging	1	neutral	0.1	neutral	3.02	deleterious	-4.39	deleterious	-7.88	high_impact	5.08	0.86	neutral	0.05	damaging	3.50	23.10	deleterious	0.03	0.35	0.96	disease	0.9	disease	0.84	disease	0.68	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.3	medium_impact	3.42	high_impact	0.30	0.8	58.16	8.8	0.69	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15057	15057	A	C	MI.8994	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	311	104	Y	S	tAc/tCc	7.3	1	0	probably_damaging	1	neutral	0.3	neutral	3.05	neutral	-1.81	deleterious	-7.86	high_impact	5.08	0.88	neutral	0.09	damaging	3.62	23.20	deleterious	0.04	0.35	0.91	disease	0.86	disease	0.8	disease	0.66	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.02	medium_impact	3.42	high_impact	0.30	0.8	58.16	8.8	0.76	P	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15059	15059	G	C	MI.8995	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	313	105	G	R	Gga/Cga	-4.4	0	0	probably_damaging	1	neutral	0.34	neutral	2.73	deleterious	-3.75	deleterious	-6.76	high_impact	4.67	0.83	neutral	0.04	damaging	3.94	23.50	deleterious	0.03	0.35	0.76	disease	0.9	disease	0.82	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.07	medium_impact	3.05	high_impact	0.53	0.8	58.42	8.78	0.58	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15059	15059	G	T	MI.8996	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	313	105	G	W	Gga/Tga	-4.4	0	0	probably_damaging	1	neutral	0.19	neutral	2.67	deleterious	-7.87	deleterious	-6.86	high_impact	5.22	0.84	neutral	0.05	damaging	4.40	24.10	deleterious	0.03	0.35	0.95	disease	0.93	disease	0.78	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.12	medium_impact	3.55	high_impact	0.17	0.8	58.42	8.78	0.6	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15060	15060	G	A	MI.8997	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	314	105	G	E	gGa/gAa	5.92	1	0	probably_damaging	1	neutral	0.27	neutral	2.76	deleterious	-3.46	deleterious	-6.73	high_impact	4.88	0.82	neutral	0.05	damaging	3.78	23.40	deleterious	0.02	0.35	0.68	disease	0.9	disease	0.78	disease	0.69	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.01	medium_impact	3.24	high_impact	0.29	0.8	58.42	8.78	0.74	P	1.00	polymorphism	1	0.17	rs1057516072	Likely_pathogenic	Seizure_Disorders|Bilateral_lesions_of_basal_ganglia	354292	MedGen:C0014544,Orphanet:ORPHA166463|MedGen:CN239810	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	15060	15060	G	T	MI.8998	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	314	105	G	V	gGa/gTa	5.92	1	0	probably_damaging	1	neutral	0.49	neutral	2.7	deleterious	-4.77	deleterious	-7.65	high_impact	5.22	0.84	neutral	0.07	damaging	3.76	23.30	deleterious	0.03	0.35	0.71	disease	0.91	disease	0.75	disease	0.7	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.21	medium_impact	3.55	high_impact	0.19	0.8	58.42	8.78	0.71	P	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15060	15060	G	C	MI.8999	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	314	105	G	A	gGa/gCa	5.92	1	0	probably_damaging	1	neutral	0.49	neutral	2.76	deleterious	-3.33	deleterious	-5.01	high_impact	4.42	0.84	neutral	0.1	damaging	3.07	22.40	deleterious	0.04	0.35	0.42	neutral	0.8	disease	0.71	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.21	medium_impact	2.82	high_impact	0.51	0.8	58.42	8.78	0.5	N	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8530	8530	A	T	MI.9	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	4	2	N	Y	Aac/Tac	7.3	1	0	probably_damaging	0.99	deleterious	0.04	neutral	4.61	neutral	-1.66	deleterious	-4.59	medium_impact	2.6	0.89	neutral	0.44	neutral	4.16	23.80	deleterious	0.46	0.65	0.48	neutral	0.44	neutral	0.26	neutral	0.46	neutral	1	1	deleterious	0.03	neutral	5	deleterious	0.68	deleterious	-2.65	low_impact	-0.49	medium_impact	1.13	medium_impact	0.37	0.9	41.59	7.23	0.63	P	1.00	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8567	8567	T	C	MI.90	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	41	14	I	T	aTc/aCc	-4.27	0	0	benign	0.39	neutral	0.25	neutral	4.6	neutral	-0.76	deleterious	-2.6	neutral_impact	0.08	0.96	neutral	0.83	neutral	4.14	23.80	deleterious	0.54	0.65	0.32	neutral	0.3	neutral	0.44	neutral	0.45	neutral	1	0.71	neutral	0.43	neutral	-6	neutral	0.37	neutral	-0.57	medium_impact	0.02	medium_impact	-1.03	low_impact	0.54	0.9	13.72	12.42	0.46	N	0.47	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8950	8950	G	A	MI.900	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	424	142	V	I	Gtt/Att	-2.19	0	0.01	benign	0	neutral	0.63	neutral	4.21	neutral	-1	neutral	0.12	neutral_impact	0.08	0.87	neutral	0.97	neutral	-0.97	0.02	neutral	0.4	0.65	0.5	neutral	0.04	neutral	0.3	neutral	0.14	neutral	7	0.37	neutral	0.82	deleterious	-6	neutral	0.11	neutral	2.09	high_impact	0.42	medium_impact	-1.03	low_impact	0.76	0.9	11.95	13.75	0.47	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	COSM1155687	CPD	29.93	G8950A	LDYT	+	-	Reported	2	.	P	P	neutral
chrM	15062	15062	T	G	MI.9000	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	316	106	S	A	Tca/Gca	-9.68	0	0	probably_damaging	0.99	neutral	0.49	neutral	3.39	neutral	0.01	deleterious	-2.65	high_impact	4.21	0.88	neutral	0.12	damaging	3.31	22.90	deleterious	0.14	0.4	0.51	disease	0.72	disease	0.73	disease	0.69	disease	4	0.99	deleterious	0.25	neutral	2	deleterious	0.80	deleterious	-2.59	low_impact	0.21	medium_impact	2.63	high_impact	0.47	0.8	57.89	8.61	0.32	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15062	15062	T	C	MI.9001	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	316	106	S	P	Tca/Cca	-9.68	0	0	probably_damaging	1	neutral	0.2	neutral	2.96	deleterious	-4.49	deleterious	-4.42	high_impact	4.64	0.89	neutral	0.06	damaging	3.81	23.40	deleterious	0.04	0.35	0.87	disease	0.85	disease	0.74	disease	0.62	disease	2	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.1	medium_impact	3.02	high_impact	0.35	0.8	57.89	8.61	0.57	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15062	15062	T	A	MI.9002	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	316	106	S	T	Tca/Aca	-9.68	0	0	probably_damaging	0.99	neutral	0.39	neutral	3	neutral	-2.74	deleterious	-2.65	high_impact	4.35	0.87	neutral	0.08	damaging	2.12	16.99	deleterious	0.13	0.4	0.74	disease	0.77	disease	0.73	disease	0.69	disease	4	0.99	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.12	medium_impact	2.76	high_impact	0.62	0.8	57.89	8.61	0.38	N	0.70	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15063	15063	C	T	MI.9003	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	317	106	S	L	tCa/tTa	7.3	1	0	probably_damaging	1	neutral	0.64	neutral	3	deleterious	-3.05	deleterious	-5.3	high_impact	4.41	0.87	neutral	0.05	damaging	4.53	24.30	deleterious	0.03	0.35	0.9	disease	0.91	disease	0.71	disease	0.61	disease	2	1	deleterious	0.32	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.36	medium_impact	2.81	high_impact	0.49	0.8	57.89	8.61	0.56	P	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15063	15063	C	G	MI.9004	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	317	106	S	W	tCa/tGa	7.3	1	0	probably_damaging	1	neutral	0.19	neutral	2.95	deleterious	-5.82	deleterious	-6.19	high_impact	5.45	0.89	neutral	0.07	damaging	4.26	23.90	deleterious	0.04	0.35	0.98	disease	0.92	disease	0.78	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.12	medium_impact	3.76	high_impact	0.16	0.8	57.89	8.61	0.71	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15065	15065	T	C	MI.9005	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	319	107	F	L	Ttt/Ctt	-15.18	0	0	probably_damaging	0.99	neutral	0.63	neutral	2.69	deleterious	-3.36	deleterious	-3.78	high_impact	3.56	0.88	neutral	0.23	damaging	2.41	18.87	deleterious	0.12	0.4	0.55	disease	0.71	disease	0.69	disease	0.71	disease	4	0.99	deleterious	0.32	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.35	medium_impact	2.04	high_impact	0.66	0.8	22.89	29.41	0.23	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15065	15065	T	A	MI.9006	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	319	107	F	I	Ttt/Att	-15.18	0	0	probably_damaging	1	neutral	0.39	neutral	2.67	deleterious	-4.76	deleterious	-3.78	high_impact	3.56	0.87	neutral	0.27	damaging	4.11	23.70	deleterious	0.1	0.4	0.71	disease	0.68	disease	0.71	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.12	medium_impact	2.04	high_impact	0.42	0.8	22.89	29.41	0.33	N	0.61	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15065	15065	T	G	MI.9007	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	319	107	F	V	Ttt/Gtt	-15.18	0	0	probably_damaging	1	neutral	0.49	neutral	2.67	deleterious	-4.64	deleterious	-3.91	high_impact	4.11	0.88	neutral	0.3	neutral	3.77	23.40	deleterious	0.06	0.35	0.69	disease	0.79	disease	0.72	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.21	medium_impact	2.54	high_impact	0.31	0.8	22.89	29.41	0.33	N	0.71	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15066	15066	T	C	MI.9008	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	320	107	F	S	tTt/tCt	7.3	1	0	probably_damaging	1	neutral	0.42	neutral	2.67	deleterious	-5.22	deleterious	-4.77	medium_impact	2.67	0.86	neutral	0.23	damaging	3.99	23.60	deleterious	0.03	0.35	0.75	disease	0.72	disease	0.67	disease	0.71	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.87	deleterious	-3.53	low_impact	0.15	medium_impact	1.23	medium_impact	0.18	0.8	22.89	29.41	0.51	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15066	15066	T	A	MI.9009	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	320	107	F	Y	tTt/tAt	7.3	1	0	probably_damaging	0.99	neutral	1	neutral	3.88	neutral	2.88	neutral	2.63	neutral_impact	-1.03	0.92	neutral	0.87	neutral	0.03	2.83	deleterious	0.12	0.4	0.27	neutral	0.07	neutral	0.28	neutral	0.17	neutral	7	0.99	deleterious	0.51	deleterious	-2	neutral	0.68	deleterious	-2.59	low_impact	1.85	high_impact	-2.13	low_impact	0.59	0.8	22.89	29.41	0.53	P	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8950	8950	G	T	MI.901	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	424	142	V	F	Gtt/Ttt	-2.19	0	0.01	benign	0.13	deleterious	0.04	neutral	4.13	neutral	-1.67	deleterious	-3.43	medium_impact	2.54	0.79	neutral	0.5	neutral	2.02	16.32	deleterious	0.17	0.65	0.63	disease	0.77	disease	0.65	disease	0.71	disease	4	0.96	neutral	0.46	neutral	1	deleterious	0.31	neutral	0.03	medium_impact	-0.49	medium_impact	1.08	medium_impact	0.52	0.9	11.95	13.75	0.3	N	0.93	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15066	15066	T	G	MI.9010	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	320	107	F	C	tTt/tGt	7.3	1	0	probably_damaging	1	neutral	0.17	neutral	2.66	deleterious	-6.71	deleterious	-4.79	high_impact	3.77	0.91	neutral	0.23	damaging	4.04	23.70	deleterious	0.04	0.35	0.89	disease	0.83	disease	0.73	disease	0.66	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.15	medium_impact	2.23	high_impact	0.15	0.8	22.89	29.41	0.57	P	0.85	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15067	15067	T	G	MI.9011	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	321	107	F	L	ttT/ttG	2.94	0.98	0.1	probably_damaging	0.99	neutral	0.63	neutral	2.69	deleterious	-3.36	deleterious	-3.78	high_impact	3.56	0.88	neutral	0.23	damaging	2.78	21.30	deleterious	0.12	0.4	0.55	disease	0.71	disease	0.69	disease	0.71	disease	4	0.99	deleterious	0.32	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.35	medium_impact	2.04	high_impact	0.66	0.8	22.89	29.41	0.47	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15067	15067	T	A	MI.9012	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	321	107	F	L	ttT/ttA	2.94	0.98	0.1	probably_damaging	0.99	neutral	0.63	neutral	2.69	deleterious	-3.36	deleterious	-3.78	high_impact	3.56	0.88	neutral	0.23	damaging	2.91	21.90	deleterious	0.12	0.4	0.55	disease	0.71	disease	0.69	disease	0.71	disease	4	0.99	deleterious	0.32	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.35	medium_impact	2.04	high_impact	0.66	0.8	22.89	29.41	0.48	N	0.70	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15068	15068	C	T	MI.9013	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	322	108	L	F	Ctc/Ttc	-1.19	0	0	probably_damaging	0.9	neutral	0.49	neutral	3.09	neutral	-2.61	deleterious	-2.86	medium_impact	2.88	0.95	neutral	0.25	damaging	3.86	23.50	deleterious	0.13	0.4	0.58	disease	0.73	disease	0.21	neutral	0.36	neutral	3	0.9	neutral	0.3	neutral	1	deleterious	0.72	deleterious	-1.62	low_impact	0.21	medium_impact	1.42	medium_impact	0.50	0.8	21.32	23.47	0.28	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15068	15068	C	G	MI.9014	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	322	108	L	V	Ctc/Gtc	-1.19	0	0	benign	0.22	neutral	0.34	neutral	3.11	neutral	-1.17	neutral	-1.78	medium_impact	2.64	0.98	neutral	0.6	neutral	1.94	15.81	deleterious	0.18	0.45	0.37	neutral	0.61	disease	0.33	neutral	0.21	neutral	6	0.59	neutral	0.56	deleterious	-3	neutral	0.27	neutral	-0.22	medium_impact	0.07	medium_impact	1.2	medium_impact	0.45	0.8	21.32	23.47	0.38	N	0.07	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15068	15068	C	A	MI.9015	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	322	108	L	I	Ctc/Atc	-1.19	0	0	possibly_damaging	0.44	neutral	0.3	neutral	3.1	neutral	-1.8	neutral	-1.23	medium_impact	2.54	0.96	neutral	0.71	neutral	2.73	21.00	deleterious	0.2	0.45	0.44	neutral	0.55	disease	0.19	neutral	0.2	neutral	6	0.66	neutral	0.43	neutral	0	NA	0.32	neutral	-0.63	medium_impact	0.02	medium_impact	1.11	medium_impact	0.54	0.8	21.32	23.47	0.48	N	0.22	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15069	15069	T	A	MI.9016	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	323	108	L	H	cTc/cAc	-1.42	0	0	probably_damaging	0.96	neutral	0.31	neutral	3.13	neutral	-1.25	deleterious	-5.05	medium_impact	3.41	0.93	neutral	0.21	damaging	4.02	23.60	deleterious	0.03	0.35	0.52	disease	0.77	disease	0.25	neutral	0.4	neutral	2	0.97	neutral	0.18	neutral	1	deleterious	0.75	deleterious	-2.02	low_impact	0.03	medium_impact	1.9	medium_impact	0.24	0.8	21.32	23.47	0.38	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15069	15069	T	C	MI.9017	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	323	108	L	P	cTc/cCc	-1.42	0	0	probably_damaging	0.95	neutral	0.11	neutral	3.1	neutral	-1.73	deleterious	-5	high_impact	4.38	0.94	neutral	0.16	damaging	3.80	23.40	deleterious	0.01	0.35	0.56	disease	0.88	disease	0.51	disease	0.63	disease	3	0.98	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-1.92	low_impact	-0.27	medium_impact	2.78	high_impact	0.08	0.8	21.32	23.47	0.48	N	0.67	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15069	15069	T	G	MI.9018	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	323	108	L	R	cTc/cGc	-1.42	0	0	possibly_damaging	0.87	neutral	0.18	neutral	3.33	neutral	2.75	deleterious	-4.24	medium_impact	2.77	0.94	neutral	0.18	damaging	4.05	23.70	deleterious	0.02	0.35	0.16	neutral	0.88	disease	0.32	neutral	0.66	disease	3	0.93	neutral	0.16	neutral	0	NA	0.68	deleterious	-1.5	low_impact	-0.14	medium_impact	1.32	medium_impact	0.20	0.8	21.32	23.47	0.36	N	0.52	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15071	15071	T	A	MI.9019	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	325	109	Y	N	Tac/Aac	-10.6	0	0.01	possibly_damaging	0.71	neutral	0.29	neutral	3.12	deleterious	-3.73	deleterious	-5.35	low_impact	0.94	0.83	neutral	0.54	neutral	2.72	20.90	deleterious	0.09	0.35	0.42	neutral	0.83	disease	0.36	neutral	0.19	neutral	6	0.78	neutral	0.29	neutral	-3	neutral	0.51	deleterious	-1.09	low_impact	0.01	medium_impact	-0.34	medium_impact	0.30	0.8	25.53	33.41	0.33	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8951	8951	T	A	MI.902	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	425	142	V	D	gTt/gAt	1.29	0.65	0.01	benign	0.38	deleterious	0	neutral	4	deleterious	-5.86	deleterious	-5.7	high_impact	3.83	0.79	neutral	0.44	neutral	2.91	21.90	deleterious	0.07	0.65	0.93	disease	0.79	disease	0.74	disease	0.83	disease	7	1	deleterious	0.31	neutral	2	deleterious	0.55	deleterious	-0.55	medium_impact	-1.4	low_impact	2.19	high_impact	0.54	0.9	11.95	13.75	0.33	N	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15071	15071	T	G	MI.9020	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	325	109	Y	D	Tac/Gac	-10.6	0	0.01	possibly_damaging	0.78	neutral	0.17	neutral	3.11	deleterious	-4.44	deleterious	-6.41	high_impact	3.81	0.79	neutral	0.38	neutral	3.78	23.40	deleterious	0.05	0.35	0.45	neutral	0.91	disease	0.54	disease	0.64	disease	3	0.89	neutral	0.2	neutral	1	deleterious	0.62	deleterious	-1.24	low_impact	-0.15	medium_impact	2.27	high_impact	0.26	0.8	25.53	33.41	0.38	N	0.68	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15071	15071	T	C	MI.9021	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	325	109	Y	H	Tac/Cac	-10.6	0	0.01	benign	0.04	neutral	0.46	neutral	3.09	deleterious	-3.91	deleterious	-3.23	medium_impact	2.91	0.78	neutral	0.66	neutral	3.37	22.90	deleterious	0.13	0.4	0.49	neutral	0.81	disease	0.32	neutral	0.44	neutral	1	0.5	neutral	0.71	deleterious	-3	neutral	0.26	neutral	0.56	medium_impact	0.18	medium_impact	1.45	medium_impact	0.34	0.8	25.53	33.41	0.28	N	0.06	polymorphism	1	0.03	rs199999794	Likely_benign	not_provided	438981	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15072	15072	A	T	MI.9022	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	326	109	Y	F	tAc/tTc	0.18	0	0	possibly_damaging	0.55	neutral	0.7	neutral	3.09	neutral	-0.42	neutral	-1.82	neutral_impact	0.52	0.94	neutral	0.96	neutral	0.66	8.54	deleterious	0.17	0.45	0.22	neutral	0.43	neutral	0.24	neutral	0.41	neutral	2	0.46	neutral	0.58	deleterious	-3	neutral	0.30	neutral	-0.81	medium_impact	0.42	medium_impact	-0.72	medium_impact	0.37	0.8	25.53	33.41	0.32	N	0.04	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15072	15072	A	G	MI.9023	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	326	109	Y	C	tAc/tGc	0.18	0	0	benign	0.06	neutral	0.15	neutral	3.07	deleterious	-4.12	deleterious	-5.74	high_impact	3.81	0.74	neutral	0.42	neutral	3.47	23.00	deleterious	0.04	0.35	0.66	disease	0.92	disease	0.5	neutral	0.61	disease	2	0.84	neutral	0.55	deleterious	-2	neutral	0.29	neutral	0.38	medium_impact	-0.19	medium_impact	2.27	high_impact	0.13	0.8	25.53	33.41	0.41	N	0.59	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15072	15072	A	C	MI.9024	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	326	109	Y	S	tAc/tCc	0.18	0	0	possibly_damaging	0.67	neutral	0.4	neutral	3.13	neutral	-2.65	deleterious	-5.48	medium_impact	2.42	0.92	neutral	0.85	neutral	3.53	23.10	deleterious	0.06	0.35	0.17	neutral	0.85	disease	0.47	neutral	0.2	neutral	6	0.69	neutral	0.37	neutral	0	NA	0.51	deleterious	-1.02	low_impact	0.13	medium_impact	1	medium_impact	0.42	0.8	25.53	33.41	0.37	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15074	15074	T	C	MI.9025	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	328	110	S	P	Tca/Cca	-5.78	0	0	benign	0.01	neutral	0.21	neutral	3.49	neutral	3.22	neutral	-1.15	neutral_impact	-0.12	0.96	neutral	0.78	neutral	2.44	19.08	deleterious	0.12	0.4	0.19	neutral	0.88	disease	0.27	neutral	0.46	neutral	1	0.79	neutral	0.6	deleterious	-6	neutral	0.19	neutral	1.13	medium_impact	-0.09	medium_impact	-1.3	low_impact	0.13	0.8	20	24.36	0.33	N	0.27	polymorphism	1	0.02	rs201169089	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15074	15074	T	A	MI.9026	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	328	110	S	T	Tca/Aca	-5.78	0	0	benign	0.3	neutral	0.4	neutral	3.17	neutral	-0.32	neutral	-0.47	neutral_impact	-0.82	0.97	neutral	0.96	neutral	0.43	6.88	deleterious	0.37	0.5	0.26	neutral	0.33	neutral	0.12	neutral	0.44	neutral	1	0.52	neutral	0.55	deleterious	-6	neutral	0.13	neutral	-0.39	medium_impact	0.13	medium_impact	-1.94	low_impact	0.48	0.8	20	24.36	0.48	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15074	15074	T	G	MI.9027	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	328	110	S	A	Tca/Gca	-5.78	0	0	benign	0.09	neutral	0.51	neutral	3.18	neutral	0.03	neutral	-0.8	low_impact	1.31	0.98	neutral	0.69	neutral	0.26	5.30	deleterious	0.37	0.5	0.25	neutral	0.49	neutral	0.23	neutral	0.46	neutral	1	0.42	neutral	0.71	deleterious	-6	neutral	0.15	neutral	0.21	medium_impact	0.23	medium_impact	0	medium_impact	0.20	0.8	20	24.36	0.41	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15075	15075	C	G	MI.9028	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	329	110	S	W	tCa/tGa	-1.88	0	0	possibly_damaging	0.89	neutral	0.19	neutral	3.13	deleterious	-4.08	deleterious	-2.5	low_impact	1.77	0.95	neutral	0.44	neutral	3.02	22.30	deleterious	0.08	0.35	0.75	disease	0.89	disease	0.45	neutral	0.64	disease	3	0.93	neutral	0.15	neutral	-3	neutral	0.71	deleterious	-1.58	low_impact	-0.12	medium_impact	0.41	medium_impact	0.14	0.8	20	24.36	0.38	N	0.19	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15075	15075	C	T	MI.9029	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	329	110	S	L	tCa/tTa	-1.88	0	0	benign	0.01	neutral	0.65	neutral	3.16	neutral	-0.58	neutral	-1.21	neutral_impact	-0.76	0.98	neutral	0.96	neutral	1.88	15.48	deleterious	0.15	0.4	0.14	neutral	0.7	disease	0.26	neutral	0.19	neutral	6	0.34	neutral	0.82	deleterious	-6	neutral	0.13	neutral	1.13	medium_impact	0.37	medium_impact	-1.88	low_impact	0.35	0.8	20	24.36	0.32	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8951	8951	T	C	MI.903	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	425	142	V	A	gTt/gCt	1.29	0.65	0.01	benign	0.05	deleterious	0	neutral	4.08	neutral	-2.33	deleterious	-3.51	medium_impact	2.62	0.8	neutral	0.64	neutral	1.73	14.60	neutral	0.29	0.65	0.66	disease	0.4	neutral	0.6	disease	0.66	disease	3	1	deleterious	0.48	deleterious	1	deleterious	0.22	neutral	0.46	medium_impact	-1.4	low_impact	1.15	medium_impact	0.30	0.9	11.95	13.75	0.34	N	0.88	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15077	15077	G	A	MI.9030	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	331	111	E	K	Gaa/Aaa	0.64	0.17	0.01	probably_damaging	1	neutral	0.32	neutral	3.16	neutral	-0.19	deleterious	-2.86	low_impact	1.21	0.98	neutral	0.55	neutral	4.04	23.70	deleterious	0.14	0.4	0.27	neutral	0.85	disease	0.46	neutral	0.18	neutral	7	1	deleterious	0.16	neutral	-2	neutral	0.81	deleterious	-3.53	low_impact	0.05	medium_impact	-0.1	medium_impact	0.64	0.8	23.95	17.94	0.45	N	1.00	polymorphism	1	0.03	rs201943501	.	.	.	.	.	COSM1497292	CPD	5.35	G15077A	DEAF	+	-	Reported	2	N	P	N,P	neutral
chrM	15077	15077	G	C	MI.9031	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	331	111	E	Q	Gaa/Caa	0.64	0.17	0.01	probably_damaging	1	neutral	0.29	neutral	3.13	neutral	-0.92	neutral	-2.34	medium_impact	3.25	0.92	neutral	0.48	neutral	3.03	22.30	deleterious	0.36	0.5	0.41	neutral	0.73	disease	0.58	disease	0.52	disease	0	1	deleterious	0.15	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.01	medium_impact	1.76	medium_impact	0.44	0.8	23.95	17.94	0.38	N	0.95	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15078	15078	A	C	MI.9032	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	332	111	E	A	gAa/gCa	4.31	1	0	probably_damaging	1	neutral	0.5	neutral	3.12	neutral	-0.42	deleterious	-4.81	medium_impact	2.96	0.94	neutral	0.54	neutral	3.22	22.70	deleterious	0.12	0.4	0.41	neutral	0.78	disease	0.58	disease	0.51	disease	0	1	deleterious	0.25	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.22	medium_impact	1.49	medium_impact	0.32	0.8	23.95	17.94	0.48	N	0.82	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15078	15078	A	G	MI.9033	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	332	111	E	G	gAa/gGa	4.31	1	0	probably_damaging	1	neutral	0.36	neutral	3.11	neutral	-1.89	deleterious	-5.72	medium_impact	2.47	0.94	neutral	0.54	neutral	3.85	23.40	deleterious	0.13	0.4	0.57	disease	0.79	disease	0.67	disease	0.53	disease	1	1	deleterious	0.18	neutral	1	deleterious	0.80	deleterious	-3.53	low_impact	0.09	medium_impact	1.05	medium_impact	0.30	0.8	23.95	17.94	0.52	N	0.77	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15078	15078	A	T	MI.9034	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	332	111	E	V	gAa/gTa	4.31	1	0	probably_damaging	1	neutral	0.54	neutral	3.08	neutral	-1.63	deleterious	-5.61	high_impact	3.6	0.94	neutral	0.53	neutral	3.65	23.20	deleterious	0.08	0.35	0.6	disease	0.9	disease	0.68	disease	0.68	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.26	medium_impact	2.08	high_impact	0.33	0.8	23.95	17.94	0.48	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15079	15079	A	T	MI.9035	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	333	111	E	D	gaA/gaT	6.84	1	0	probably_damaging	0.98	neutral	0.2	neutral	3.1	neutral	-1	neutral	-2.48	high_impact	4.2	0.92	neutral	0.62	neutral	1.97	16.01	deleterious	0.35	0.5	0.45	neutral	0.79	disease	0.51	disease	0.56	disease	1	0.98	deleterious	0.11	neutral	2	deleterious	0.77	deleterious	-2.31	low_impact	-0.1	medium_impact	2.62	high_impact	0.50	0.8	23.95	17.94	0.67	P	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15079	15079	A	C	MI.9036	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	333	111	E	D	gaA/gaC	6.84	1	0	probably_damaging	0.98	neutral	0.2	neutral	3.1	neutral	-1	neutral	-2.48	high_impact	4.2	0.92	neutral	0.62	neutral	1.86	15.37	deleterious	0.35	0.5	0.45	neutral	0.79	disease	0.51	disease	0.56	disease	1	0.98	deleterious	0.11	neutral	2	deleterious	0.77	deleterious	-2.31	low_impact	-0.1	medium_impact	2.62	high_impact	0.50	0.8	23.95	17.94	0.66	P	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15080	15080	A	T	MI.9037	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	334	112	T	S	Acc/Tcc	-0.04	0.92	0	probably_damaging	0.99	neutral	0.46	neutral	3.15	neutral	-1.58	deleterious	-3.51	high_impact	3.92	0.84	neutral	0.49	neutral	2.83	21.50	deleterious	0.28	0.45	0.35	neutral	0.75	disease	0.7	disease	0.68	disease	4	0.99	deleterious	0.24	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.18	medium_impact	2.37	high_impact	0.42	0.8	56.84	8.7	0.39	N	0.81	polymorphism	1	0.03	rs386829235	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15080	15080	A	C	MI.9038	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	334	112	T	P	Acc/Ccc	-0.04	0.92	0	probably_damaging	1	neutral	0.22	neutral	3.09	deleterious	-3.25	deleterious	-5.29	high_impact	3.71	0.84	neutral	0.32	neutral	3.33	22.90	deleterious	0.04	0.35	0.68	disease	0.85	disease	0.75	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.08	medium_impact	2.18	high_impact	0.35	0.8	56.84	8.7	0.38	N	0.95	polymorphism	1	0.07	rs386829235	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15080	15080	A	G	MI.9039	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	334	112	T	A	Acc/Gcc	-0.04	0.92	0	probably_damaging	0.99	neutral	0.54	neutral	3.14	neutral	-1.58	deleterious	-4.36	medium_impact	3.05	0.78	neutral	0.54	neutral	2.90	21.80	deleterious	0.2	0.45	0.35	neutral	0.7	disease	0.62	disease	0.53	disease	1	0.99	deleterious	0.28	neutral	1	deleterious	0.75	deleterious	-2.59	low_impact	0.26	medium_impact	1.58	medium_impact	0.32	0.8	56.84	8.7	0.3	N	0.59	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8951	8951	T	G	MI.904	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	425	142	V	G	gTt/gGt	1.29	0.65	0.01	benign	0.28	deleterious	0	neutral	4.01	deleterious	-4.8	deleterious	-6.21	medium_impact	3.27	0.78	neutral	0.49	neutral	2.09	16.82	deleterious	0.13	0.65	0.87	disease	0.66	disease	0.64	disease	0.72	disease	4	1	deleterious	0.36	neutral	1	deleterious	0.38	neutral	-0.37	medium_impact	-1.4	low_impact	1.71	medium_impact	0.52	0.9	11.95	13.75	0.32	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15081	15081	C	A	MI.9040	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	335	112	T	N	aCc/aAc	6.84	1	0	probably_damaging	1	neutral	0.36	neutral	3.12	neutral	-1.83	deleterious	-4.42	high_impact	4.51	0.83	neutral	0.44	neutral	3.70	23.30	deleterious	0.21	0.45	0.53	disease	0.87	disease	0.72	disease	0.68	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.09	medium_impact	2.9	high_impact	0.49	0.8	56.84	8.7	0.65	P	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15081	15081	C	G	MI.9041	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	335	112	T	S	aCc/aGc	6.84	1	0	probably_damaging	0.99	neutral	0.46	neutral	3.15	neutral	-1.58	deleterious	-3.51	high_impact	3.92	0.84	neutral	0.49	neutral	3.15	22.60	deleterious	0.28	0.45	0.35	neutral	0.75	disease	0.7	disease	0.68	disease	4	0.99	deleterious	0.24	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.18	medium_impact	2.37	high_impact	0.42	0.8	56.84	8.7	0.57	P	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15081	15081	C	T	MI.9042	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	335	112	T	I	aCc/aTc	6.84	1	0	probably_damaging	1	neutral	0.44	neutral	3.08	deleterious	-3.02	deleterious	-5.29	high_impact	4.24	0.84	neutral	0.48	neutral	3.82	23.40	deleterious	0.08	0.35	0.37	neutral	0.89	disease	0.7	disease	0.7	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.17	medium_impact	2.66	high_impact	0.42	0.8	56.84	8.7	0.5	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15083	15083	T	C	MI.9043	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	337	113	W	R	Tga/Cga	-6.7	0	0	probably_damaging	1	neutral	0.35	neutral	1.38	deleterious	-9.48	deleterious	-12.48	high_impact	4.8	0.71	neutral	0.29	neutral	3.43	23.00	deleterious	0.02	0.35	0.69	disease	0.94	disease	0.87	disease	0.79	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.08	medium_impact	3.17	high_impact	0.07	0.8	57.89	8.78	0.52	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15083	15083	T	G	MI.9044	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	337	113	W	G	Tga/Gga	-6.7	0	0	probably_damaging	1	neutral	0.33	neutral	1.38	deleterious	-9.89	deleterious	-11.59	high_impact	4.94	0.74	neutral	0.43	neutral	3.76	23.30	deleterious	0.03	0.35	0.9	disease	0.89	disease	0.84	disease	0.63	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.06	medium_impact	3.29	high_impact	0.06	0.8	57.89	8.78	0.58	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15084	15084	G	C	MI.9045	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	338	113	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.4	neutral	1.38	deleterious	-9.33	deleterious	-12.48	high_impact	4.68	0.75	neutral	0.41	neutral	3.89	23.50	deleterious	0.02	0.35	0.86	disease	0.93	disease	0.83	disease	0.64	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.13	medium_impact	3.06	high_impact	0.05	0.8	57.89	8.78	0.56	P	0.99	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15084	15084	G	T	MI.9046	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	338	113	W	L	tGa/tTa	7.3	1	0	probably_damaging	1	neutral	0.67	neutral	1.41	deleterious	-7.74	deleterious	-11.59	high_impact	5.14	0.74	neutral	0.35	neutral	4.04	23.70	deleterious	0.03	0.35	0.69	disease	0.92	disease	0.82	disease	0.72	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.39	medium_impact	3.47	high_impact	0.03	0.8	57.89	8.78	0.62	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15085	15085	A	C	MI.9047	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	339	113	W	C	tgA/tgC	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	1.38	deleterious	-10.09	deleterious	-11.58	high_impact	4.8	0.88	neutral	0.29	neutral	3.91	23.50	deleterious	0.02	0.35	0.95	disease	0.92	disease	0.86	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.17	high_impact	0.05	0.8	57.89	8.78	0.57	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15085	15085	A	T	MI.9048	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	339	113	W	C	tgA/tgT	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	1.38	deleterious	-10.09	deleterious	-11.58	high_impact	4.8	0.88	neutral	0.29	neutral	4.08	23.70	deleterious	0.02	0.35	0.95	disease	0.92	disease	0.86	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.17	high_impact	0.05	0.8	57.89	8.78	0.57	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15086	15086	A	T	MI.9049	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	340	114	N	Y	Aac/Tac	2.02	1	0	probably_damaging	1	neutral	1	neutral	3.19	deleterious	-4.27	deleterious	-6.03	medium_impact	2.84	0.86	neutral	0.08	damaging	3.64	23.20	deleterious	0.1	0.4	0.61	disease	0.9	disease	0.43	neutral	0.45	neutral	1	1	deleterious	0.5	deleterious	1	deleterious	0.83	deleterious	-3.53	low_impact	1.85	high_impact	1.39	medium_impact	0.20	0.8	53.95	8.23	0.27	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8953	8953	A	T	MI.905	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	427	143	I	F	Att/Ttt	-5.42	0	0	probably_damaging	0.99	deleterious	0.03	neutral	4.24	neutral	-1.21	deleterious	-3.3	medium_impact	2.12	0.86	neutral	0.4	neutral	3.79	23.40	deleterious	0.3	0.65	0.45	neutral	0.57	disease	0.65	disease	0.69	disease	4	1	deleterious	0.02	neutral	5	deleterious	0.71	deleterious	-2.65	low_impact	-0.56	medium_impact	0.72	medium_impact	0.75	0.9	19.47	13.18	0.35	N	0.76	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15086	15086	A	C	MI.9050	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	340	114	N	H	Aac/Cac	2.02	1	0	probably_damaging	1	neutral	0.53	neutral	3.16	deleterious	-3.83	deleterious	-3.86	high_impact	4.61	0.85	neutral	0.08	damaging	3.04	22.30	deleterious	0.31	0.45	0.69	disease	0.86	disease	0.63	disease	0.65	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.25	medium_impact	2.99	high_impact	0.22	0.8	53.95	8.23	0.44	N	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15086	15086	A	G	MI.9051	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	340	114	N	D	Aac/Gac	2.02	1	0	probably_damaging	0.99	neutral	0.2	neutral	3.15	neutral	-2.64	deleterious	-4.04	high_impact	4.61	0.84	neutral	0.1	damaging	3.42	23.00	deleterious	0.46	0.55	0.68	disease	0.83	disease	0.7	disease	0.68	disease	4	0.99	deleterious	0.11	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	-0.1	medium_impact	2.99	high_impact	0.37	0.8	53.95	8.23	0.52	N	0.96	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15087	15087	A	C	MI.9052	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	341	114	N	T	aAc/aCc	8.44	1	0	probably_damaging	1	neutral	0.42	neutral	3.21	neutral	-0.06	deleterious	-4.62	medium_impact	2.23	0.85	neutral	0.27	damaging	2.97	22.10	deleterious	0.28	0.45	0.45	neutral	0.8	disease	0.35	neutral	0.18	neutral	6	0.99	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.15	medium_impact	0.83	medium_impact	0.28	0.8	53.95	8.23	0.47	N	0.94	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15087	15087	A	G	MI.9053	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	341	114	N	S	aAc/aGc	8.44	1	0	probably_damaging	0.98	neutral	0.41	neutral	3.19	neutral	-1.47	deleterious	-3.84	medium_impact	3.25	0.92	neutral	0.1	damaging	1.19	11.70	neutral	0.41	0.5	0.37	neutral	0.8	disease	0.4	neutral	0.19	neutral	6	0.98	neutral	0.22	neutral	1	deleterious	0.77	deleterious	-2.31	low_impact	0.14	medium_impact	1.76	medium_impact	0.20	0.8	53.95	8.23	0.51	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15087	15087	A	T	MI.9054	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	341	114	N	I	aAc/aTc	8.44	1	0	probably_damaging	1	neutral	0.42	neutral	3.44	deleterious	-3.33	deleterious	-7.09	medium_impact	3.04	0.86	neutral	0.11	damaging	3.68	23.30	deleterious	0.11	0.4	0.25	neutral	0.93	disease	0.36	neutral	0.63	disease	3	1	deleterious	0.21	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	0.15	medium_impact	1.57	medium_impact	0.15	0.8	53.95	8.23	0.43	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15088	15088	C	G	MI.9055	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	342	114	N	K	aaC/aaG	6.84	1	0	probably_damaging	1	neutral	0.3	neutral	3.21	neutral	-2.23	deleterious	-4.77	high_impact	4.61	0.86	neutral	0.07	damaging	3.77	23.40	deleterious	0.32	0.5	0.54	disease	0.88	disease	0.72	disease	0.68	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.02	medium_impact	2.99	high_impact	0.38	0.8	53.95	8.23	0.6	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15088	15088	C	A	MI.9056	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	342	114	N	K	aaC/aaA	6.84	1	0	probably_damaging	1	neutral	0.3	neutral	3.21	neutral	-2.23	deleterious	-4.77	high_impact	4.61	0.86	neutral	0.07	damaging	4.27	23.90	deleterious	0.32	0.5	0.54	disease	0.88	disease	0.72	disease	0.68	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.02	medium_impact	2.99	high_impact	0.38	0.8	53.95	8.23	0.6	P	1.00	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15089	15089	A	C	MI.9057	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	343	115	I	L	Atc/Ctc	-2.34	0	0	benign	0.16	neutral	1	neutral	3.15	neutral	-0.06	neutral	-1.36	medium_impact	2.62	0.9	neutral	0.5	neutral	1.70	14.42	neutral	0.28	0.45	0.33	neutral	0.74	disease	0.48	neutral	0.17	neutral	7	0.16	neutral	0.92	deleterious	-3	neutral	0.22	neutral	-0.06	medium_impact	1.85	high_impact	1.19	medium_impact	0.50	0.8	18.16	13.07	0.23	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15089	15089	A	G	MI.9058	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	343	115	I	V	Atc/Gtc	-2.34	0	0	benign	0.01	neutral	0.62	neutral	3.01	neutral	-1.13	neutral	-0.38	low_impact	0.88	0.94	neutral	0.92	neutral	-0.28	0.75	neutral	0.37	0.5	0.21	neutral	0.25	neutral	0.45	neutral	0.41	neutral	2	0.37	neutral	0.81	deleterious	-6	neutral	0.12	neutral	1.13	medium_impact	0.34	medium_impact	-0.39	medium_impact	0.36	0.8	18.16	13.07	0.31	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15089	15089	A	T	MI.9059	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	343	115	I	F	Atc/Ttc	-2.34	0	0	possibly_damaging	0.81	neutral	0.67	neutral	2.9	neutral	-2.84	deleterious	-3.04	high_impact	3.88	0.85	neutral	0.4	neutral	3.25	22.80	deleterious	0.17	0.45	0.64	disease	0.85	disease	0.71	disease	0.71	disease	4	0.77	neutral	0.43	neutral	1	deleterious	0.75	deleterious	-1.32	low_impact	0.39	medium_impact	2.33	high_impact	0.40	0.8	18.16	13.07	0.26	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8953	8953	A	G	MI.906	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	427	143	I	V	Att/Gtt	-5.42	0	0	probably_damaging	0.93	neutral	0.13	neutral	4.3	neutral	0.03	neutral	-0.56	low_impact	1.05	0.9	neutral	0.94	neutral	1.62	13.97	neutral	0.57	0.65	0.36	neutral	0.18	neutral	0.4	neutral	0.29	neutral	4	0.97	neutral	0.1	neutral	-2	neutral	0.58	deleterious	-1.82	low_impact	-0.18	medium_impact	-0.2	medium_impact	0.56	0.9	19.47	13.18	0.53	N	0.13	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15090	15090	T	C	MI.9060	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	344	115	I	T	aTc/aCc	0.64	0	0	possibly_damaging	0.74	neutral	0.49	neutral	3.03	neutral	-0.96	deleterious	-2.66	low_impact	1.23	0.87	neutral	0.64	neutral	1.91	15.68	deleterious	0.09	0.4	0.43	neutral	0.54	disease	0.52	disease	0.21	neutral	6	0.72	neutral	0.38	neutral	-3	neutral	0.59	deleterious	-1.16	low_impact	0.21	medium_impact	-0.08	medium_impact	0.22	0.8	18.16	13.07	0.27	N	0.99	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15090	15090	T	G	MI.9061	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	344	115	I	S	aTc/aGc	0.64	0	0	probably_damaging	0.9	neutral	0.41	neutral	3.01	neutral	-1.05	deleterious	-3.98	low_impact	1.84	0.84	neutral	0.39	neutral	4.09	23.70	deleterious	0.03	0.35	0.31	neutral	0.87	disease	0.52	disease	0.64	disease	3	0.9	neutral	0.26	neutral	-2	neutral	0.69	deleterious	-1.62	low_impact	0.14	medium_impact	0.48	medium_impact	0.21	0.8	18.16	13.07	0.25	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15090	15090	T	A	MI.9062	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	344	115	I	N	aTc/aAc	0.64	0	0	probably_damaging	0.98	neutral	0.51	neutral	2.87	deleterious	-4.2	deleterious	-4.89	high_impact	4.22	0.83	neutral	0.41	neutral	4.31	24.00	deleterious	0.09	0.35	0.78	disease	0.88	disease	0.7	disease	0.71	disease	4	0.97	neutral	0.27	neutral	2	deleterious	0.81	deleterious	-2.31	low_impact	0.23	medium_impact	2.64	high_impact	0.26	0.8	18.16	13.07	0.38	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15091	15091	C	G	MI.9063	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	345	115	I	M	atC/atG	1.33	0	0	probably_damaging	0.9	neutral	0.36	neutral	2.89	deleterious	-3.1	neutral	-1.89	medium_impact	2.27	0.9	neutral	0.64	neutral	2.99	22.20	deleterious	0.24	0.45	0.63	disease	0.66	disease	0.62	disease	0.47	neutral	1	0.91	neutral	0.23	neutral	1	deleterious	0.67	deleterious	-1.62	low_impact	0.09	medium_impact	0.87	medium_impact	0.49	0.8	18.16	13.07	0.34	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15091	15091	C	A	MI.9064	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	345	115	I	M	atC/atA	1.33	0	0	probably_damaging	0.9	neutral	0.36	neutral	2.89	deleterious	-3.1	neutral	-1.89	medium_impact	2.27	0.9	neutral	0.64	neutral	3.50	23.10	deleterious	0.24	0.45	0.63	disease	0.66	disease	0.62	disease	0.47	neutral	1	0.91	neutral	0.23	neutral	1	deleterious	0.67	deleterious	-1.62	low_impact	0.09	medium_impact	0.87	medium_impact	0.49	0.8	18.16	13.07	0.34	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15092	15092	G	A	MI.9065	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	346	116	G	S	Ggc/Agc	-8.53	0	0	possibly_damaging	0.86	neutral	0.49	neutral	1.43	deleterious	-8.91	deleterious	-5.36	high_impact	5.16	0.78	neutral	0.34	neutral	4.07	23.70	deleterious	0.03	0.35	0.92	disease	0.85	disease	0.78	disease	0.64	disease	3	0.85	neutral	0.32	neutral	1	deleterious	0.81	deleterious	-1.47	low_impact	0.21	medium_impact	3.49	high_impact	0.55	0.8	58.16	8.71	0.74	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	G15092A	MELAS	-	+	Reported	1	.	P	P	damaging
chrM	15092	15092	G	C	MI.9066	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	346	116	G	R	Ggc/Cgc	-8.53	0	0	probably_damaging	0.99	neutral	0.33	neutral	1.39	deleterious	-9.83	deleterious	-7.14	high_impact	5.16	0.79	neutral	0.24	damaging	3.80	23.40	deleterious	0.01	0.35	0.96	disease	0.92	disease	0.86	disease	0.66	disease	3	0.99	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-2.59	low_impact	0.06	medium_impact	3.49	high_impact	0.47	0.8	58.16	8.71	0.6	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15092	15092	G	T	MI.9067	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	346	116	G	C	Ggc/Tgc	-8.53	0	0	probably_damaging	0.99	neutral	0.17	neutral	1.38	deleterious	-12.02	deleterious	-8.04	high_impact	5.5	0.79	neutral	0.23	damaging	4.02	23.60	deleterious	0.02	0.35	0.97	disease	0.91	disease	0.79	disease	0.67	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-2.59	low_impact	-0.15	medium_impact	3.8	high_impact	0.24	0.8	58.16	8.71	0.55	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15093	15093	G	A	MI.9068	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	347	116	G	D	gGc/gAc	5	1	0	benign	0.16	neutral	0.19	neutral	1.39	deleterious	-9.44	deleterious	-6.25	high_impact	5.5	0.58	damaging	0.3	neutral	3.73	23.30	deleterious	0.01	0.35	0.95	disease	0.91	disease	0.86	disease	0.67	disease	3	0.78	neutral	0.52	deleterious	-2	neutral	0.50	deleterious	-0.06	medium_impact	-0.12	medium_impact	3.8	high_impact	0.15	0.8	58.16	8.71	0.56	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15093	15093	G	T	MI.9069	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	347	116	G	V	gGc/gTc	5	1	0	probably_damaging	0.99	neutral	1	neutral	1.42	deleterious	-11.25	deleterious	-8.04	high_impact	5.5	0.79	neutral	0.37	neutral	3.71	23.30	deleterious	0.01	0.35	0.96	disease	0.9	disease	0.77	disease	0.62	disease	2	0.99	deleterious	0.51	deleterious	2	deleterious	0.88	deleterious	-2.59	low_impact	1.85	high_impact	3.8	high_impact	0.16	0.8	58.16	8.71	0.63	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8953	8953	A	C	MI.907	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	427	143	I	L	Att/Ctt	-5.42	0	0	probably_damaging	0.93	neutral	0.94	neutral	4.44	neutral	0.51	neutral	-1.35	neutral_impact	0.41	0.9	neutral	0.8	neutral	2.55	19.77	deleterious	0.38	0.65	0.33	neutral	0.21	neutral	0.32	neutral	0.36	neutral	3	0.92	neutral	0.51	deleterious	-2	neutral	0.58	deleterious	-1.82	low_impact	0.97	medium_impact	-0.75	medium_impact	0.67	0.9	19.47	13.18	0.26	N	0.31	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15093	15093	G	C	MI.9070	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	347	116	G	A	gGc/gCc	5	1	0	possibly_damaging	0.81	neutral	0.61	neutral	1.45	deleterious	-8.53	deleterious	-5.36	high_impact	5.5	0.8	neutral	0.43	neutral	3.04	22.40	deleterious	0.03	0.35	0.9	disease	0.76	disease	0.77	disease	0.67	disease	3	0.78	neutral	0.4	neutral	1	deleterious	0.79	deleterious	-1.32	low_impact	0.33	medium_impact	3.8	high_impact	0.32	0.8	58.16	8.71	0.69	P	0.83	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15095	15095	A	G	MI.9071	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	349	117	I	V	Att/Gtt	-1.65	0	0	benign	0.02	neutral	0.5	neutral	3.61	neutral	2.02	neutral	0.43	neutral_impact	-1.34	0.93	neutral	0.95	neutral	-1.53	0.00	neutral	0.33	0.5	0.21	neutral	0.05	neutral	0.32	neutral	0.17	neutral	7	0.48	neutral	0.74	deleterious	-6	neutral	0.09	neutral	0.85	medium_impact	0.22	medium_impact	-2.41	low_impact	0.54	0.8	13.95	23.32	0.36	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15095	15095	A	T	MI.9072	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	349	117	I	F	Att/Ttt	-1.65	0	0	possibly_damaging	0.79	neutral	0.7	neutral	3.08	neutral	-1.07	deleterious	-3.5	medium_impact	2.48	0.92	neutral	0.52	neutral	3.45	23.00	deleterious	0.08	0.35	0.54	disease	0.85	disease	0.63	disease	0.73	disease	5	0.74	neutral	0.46	neutral	0	NA	0.67	deleterious	-1.27	low_impact	0.42	medium_impact	1.06	medium_impact	0.45	0.8	13.95	23.32	0.23	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15095	15095	A	C	MI.9073	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	349	117	I	L	Att/Ctt	-1.65	0	0	benign	0.14	neutral	0.65	neutral	3.2	neutral	0.2	neutral	-1.74	medium_impact	2.25	0.84	neutral	0.46	neutral	1.94	15.83	deleterious	0.17	0.45	0.21	neutral	0.75	disease	0.58	disease	0.68	disease	4	0.23	neutral	0.76	deleterious	-3	neutral	0.19	neutral	0	medium_impact	0.37	medium_impact	0.85	medium_impact	0.52	0.8	13.95	23.32	0.24	N	0.59	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15096	15096	T	G	MI.9074	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	350	117	I	S	aTt/aGt	0.18	0.02	0	possibly_damaging	0.79	neutral	0.4	neutral	3.06	neutral	-1.6	deleterious	-4.54	medium_impact	2.21	0.84	neutral	0.46	neutral	3.86	23.50	deleterious	0.02	0.35	0.57	disease	0.85	disease	0.6	disease	0.73	disease	5	0.79	neutral	0.31	neutral	0	NA	0.56	deleterious	-1.27	low_impact	0.13	medium_impact	0.81	medium_impact	0.35	0.8	13.95	23.32	0.26	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15096	15096	T	A	MI.9075	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	350	117	I	N	aTt/aAt	0.18	0.02	0	probably_damaging	0.94	neutral	0.31	neutral	3.02	deleterious	-3.22	deleterious	-5.43	medium_impact	2.99	0.83	neutral	0.48	neutral	4.08	23.70	deleterious	0.03	0.35	0.74	disease	0.9	disease	0.62	disease	0.73	disease	5	0.95	neutral	0.19	neutral	1	deleterious	0.79	deleterious	-1.85	low_impact	0.03	medium_impact	1.52	medium_impact	0.43	0.8	13.95	23.32	0.3	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15096	15096	T	C	MI.9076	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	350	117	I	T	aTt/aCt	0.18	0.02	0	possibly_damaging	0.52	neutral	0.39	neutral	3.08	neutral	-1.14	deleterious	-2.94	low_impact	1.28	0.94	neutral	0.69	neutral	1.65	14.15	neutral	0.03	0.35	0.42	neutral	0.67	disease	0.44	neutral	0.35	neutral	3	0.6	neutral	0.44	neutral	-3	neutral	0.43	neutral	-0.76	medium_impact	0.12	medium_impact	-0.03	medium_impact	0.28	0.8	13.95	23.32	0.34	N	0.97	polymorphism	1	0.04	rs1057516073	Uncertain_significance	Mitochondrial_myopathy	354293	Human_Phenotype_Ontology:HP:0003737,MedGen:C0162670,OMIM:251900,Orphanet:ORPHA206966	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15097	15097	T	A	MI.9077	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	351	117	I	M	atT/atA	5.69	0.87	0	possibly_damaging	0.89	neutral	0.22	neutral	3.05	neutral	-2.01	neutral	-1.97	medium_impact	2.48	0.89	neutral	0.48	neutral	3.37	22.90	deleterious	0.12	0.4	0.52	disease	0.69	disease	0.53	disease	0.49	neutral	0	0.93	neutral	0.17	neutral	0	NA	0.63	deleterious	-1.58	low_impact	-0.08	medium_impact	1.06	medium_impact	0.51	0.8	13.95	23.32	0.53	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15097	15097	T	G	MI.9078	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	351	117	I	M	atT/atG	5.69	0.87	0	possibly_damaging	0.89	neutral	0.22	neutral	3.05	neutral	-2.01	neutral	-1.97	medium_impact	2.48	0.89	neutral	0.48	neutral	3.05	22.40	deleterious	0.12	0.4	0.52	disease	0.69	disease	0.53	disease	0.49	neutral	0	0.93	neutral	0.17	neutral	0	NA	0.63	deleterious	-1.58	low_impact	-0.08	medium_impact	1.06	medium_impact	0.51	0.8	13.95	23.32	0.52	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15098	15098	A	G	MI.9079	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	352	118	I	V	Atc/Gtc	-11.97	0	0	benign	0	neutral	1	neutral	3.17	neutral	-1.62	neutral	-0.34	neutral_impact	0.44	0.98	neutral	0.94	neutral	-0.36	0.49	neutral	0.35	0.5	0.17	neutral	0.13	neutral	0.35	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	1.85	high_impact	-0.79	medium_impact	0.51	0.8	22.63	27.86	0.37	N	0.04	polymorphism	1	0.01	rs527236172	Likely_pathogenic	Neoplasm_of_ovary	153600	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	5.5	.	.	.	.	.	.	P	.	P	neutral
chrM	8954	8954	T	C	MI.908	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	428	143	I	T	aTt/aCt	-0.33	0	0	probably_damaging	0.99	deleterious	0.04	neutral	4.22	neutral	-1.7	deleterious	-3.89	medium_impact	2.65	0.9	neutral	0.44	neutral	3.34	22.90	deleterious	0.32	0.65	0.62	disease	0.43	neutral	0.6	disease	0.64	disease	3	1	deleterious	0.03	neutral	5	deleterious	0.72	deleterious	-2.65	low_impact	-0.49	medium_impact	1.17	medium_impact	0.66	0.9	19.47	13.18	0.47	N	0.66	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15098	15098	A	C	MI.9080	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	352	118	I	L	Atc/Ctc	-11.97	0	0	benign	0.02	neutral	0.63	neutral	3.27	neutral	-1.31	neutral	-1.21	low_impact	1.31	0.97	neutral	0.86	neutral	0.36	6.22	deleterious	0.2	0.45	0.37	neutral	0.58	disease	0.31	neutral	0.22	neutral	6	0.33	neutral	0.81	deleterious	-6	neutral	0.18	neutral	0.85	medium_impact	0.35	medium_impact	0	medium_impact	0.50	0.8	22.63	27.86	0.28	N	0.28	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15098	15098	A	T	MI.9081	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	352	118	I	F	Atc/Ttc	-11.97	0	0	benign	0.33	neutral	0.23	neutral	3.11	neutral	-1.04	deleterious	-3.13	medium_impact	3.27	0.95	neutral	0.5	neutral	2.08	16.75	deleterious	0.11	0.4	0.76	disease	0.84	disease	0.6	disease	0.68	disease	4	0.72	neutral	0.45	neutral	-3	neutral	0.57	deleterious	-0.44	medium_impact	-0.06	medium_impact	1.78	medium_impact	0.49	0.8	22.63	27.86	0.37	N	0.63	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15099	15099	T	C	MI.9082	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	353	118	I	T	aTc/aCc	-1.65	0	0	benign	0.39	neutral	0.27	neutral	3.1	neutral	-1.84	deleterious	-3.46	low_impact	1.8	0.93	neutral	0.57	neutral	2.86	21.70	deleterious	0.05	0.35	0.53	disease	0.71	disease	0.4	neutral	0.37	neutral	3	0.68	neutral	0.44	neutral	-6	neutral	0.47	deleterious	-0.55	medium_impact	-0.01	medium_impact	0.44	medium_impact	0.25	0.8	22.63	27.86	0.32	N	0.49	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15099	15099	T	G	MI.9083	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	353	118	I	S	aTc/aGc	-1.65	0	0	possibly_damaging	0.56	neutral	0.12	neutral	3.02	deleterious	-3.49	deleterious	-4.5	medium_impact	2.4	0.94	neutral	0.47	neutral	3.85	23.40	deleterious	0.02	0.35	0.8	disease	0.86	disease	0.57	disease	0.66	disease	3	0.87	neutral	0.28	neutral	0	NA	0.67	deleterious	-0.83	medium_impact	-0.25	medium_impact	0.99	medium_impact	0.28	0.8	22.63	27.86	0.41	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15099	15099	T	A	MI.9084	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	353	118	I	N	aTc/aAc	-1.65	0	0	possibly_damaging	0.87	neutral	0.08	neutral	2.99	deleterious	-4.65	deleterious	-5.43	high_impact	4.25	0.93	neutral	0.48	neutral	4.07	23.70	deleterious	0.06	0.35	0.89	disease	0.87	disease	0.59	disease	0.64	disease	3	0.96	neutral	0.11	neutral	1	deleterious	0.78	deleterious	-1.5	low_impact	-0.35	medium_impact	2.67	high_impact	0.36	0.8	22.63	27.86	0.48	N	0.63	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15100	15100	C	A	MI.9085	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	354	118	I	M	atC/atA	5.69	0.87	0.01	benign	0.04	neutral	0.33	neutral	3.02	neutral	-1.97	neutral	-1.71	low_impact	1.61	0.97	neutral	0.82	neutral	2.26	17.89	deleterious	0.19	0.45	0.67	disease	0.6	disease	0.35	neutral	0.25	neutral	5	0.64	neutral	0.65	deleterious	-6	neutral	0.23	neutral	0.56	medium_impact	0.06	medium_impact	0.27	medium_impact	0.53	0.8	22.63	27.86	0.44	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15100	15100	C	G	MI.9086	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	354	118	I	M	atC/atG	5.69	0.87	0.01	benign	0.04	neutral	0.33	neutral	3.02	neutral	-1.97	neutral	-1.71	low_impact	1.61	0.97	neutral	0.82	neutral	1.79	14.91	neutral	0.19	0.45	0.67	disease	0.6	disease	0.35	neutral	0.25	neutral	5	0.64	neutral	0.65	deleterious	-6	neutral	0.23	neutral	0.56	medium_impact	0.06	medium_impact	0.27	medium_impact	0.53	0.8	22.63	27.86	0.44	N	0.02	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15101	15101	C	T	MI.9087	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	355	119	L	F	Ctc/Ttc	-2.8	0	0	probably_damaging	1	neutral	0.41	neutral	2.54	deleterious	-4.82	deleterious	-3.53	high_impact	4.58	0.92	neutral	0.1	damaging	3.86	23.50	deleterious	0.08	0.35	0.67	disease	0.78	disease	0.62	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.14	medium_impact	2.97	high_impact	0.41	0.8	56.84	8.63	0.44	N	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15101	15101	C	A	MI.9088	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	355	119	L	I	Ctc/Atc	-2.8	0	0	probably_damaging	1	neutral	0.65	neutral	2.7	neutral	-1.98	neutral	-1.72	low_impact	1.44	0.87	neutral	0.11	damaging	3.84	23.40	deleterious	0.2	0.45	0.15	neutral	0.66	disease	0.32	neutral	0.18	neutral	6	1	deleterious	0.33	neutral	-2	neutral	0.71	deleterious	-3.53	low_impact	0.37	medium_impact	0.11	medium_impact	0.57	0.8	56.84	8.63	0.19	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15101	15101	C	G	MI.9089	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	355	119	L	V	Ctc/Gtc	-2.8	0	0	probably_damaging	0.99	neutral	0.37	neutral	2.6	deleterious	-3.89	deleterious	-2.6	high_impact	4.58	0.91	neutral	0.12	damaging	2.98	22.20	deleterious	0.16	0.45	0.41	neutral	0.65	disease	0.55	disease	0.62	disease	2	0.99	deleterious	0.19	neutral	2	deleterious	0.75	deleterious	-2.59	low_impact	0.1	medium_impact	2.97	high_impact	0.57	0.8	56.84	8.63	0.4	N	0.91	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8954	8954	T	A	MI.909	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	428	143	I	N	aTt/aAt	-0.33	0	0	probably_damaging	1	deleterious	0	neutral	4.17	deleterious	-3.45	deleterious	-5.83	high_impact	3.62	0.84	neutral	0.42	neutral	4.33	24.00	deleterious	0.21	0.65	0.82	disease	0.62	disease	0.66	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.77	deleterious	-3.6	low_impact	-1.4	low_impact	2.01	high_impact	0.61	0.9	19.47	13.18	0.35	N	0.86	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15102	15102	T	C	MI.9090	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	356	119	L	P	cTc/cCc	-0.04	0	0	probably_damaging	1	deleterious	0.02	neutral	2.51	deleterious	-7.28	deleterious	-6.22	high_impact	5.13	0.87	neutral	0.06	damaging	3.83	23.40	deleterious	0.02	0.35	0.92	disease	0.85	disease	0.72	disease	0.63	disease	3	1	deleterious	0.01	neutral	6	deleterious	0.89	deleterious	-3.53	low_impact	-0.69	medium_impact	3.46	high_impact	0.31	0.8	56.84	8.63	0.58	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15102	15102	T	G	MI.9091	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	356	119	L	R	cTc/cGc	-0.04	0	0	probably_damaging	1	deleterious	0.04	neutral	2.52	deleterious	-6.44	deleterious	-5.34	high_impact	5.13	0.87	neutral	0.06	damaging	4.09	23.70	deleterious	0.02	0.35	0.91	disease	0.91	disease	0.72	disease	0.63	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.91	deleterious	-3.53	low_impact	-0.53	medium_impact	3.46	high_impact	0.22	0.8	56.84	8.63	0.61	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15102	15102	T	A	MI.9092	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	356	119	L	H	cTc/cAc	-0.04	0	0	probably_damaging	1	neutral	0.06	neutral	2.51	deleterious	-7.36	deleterious	-6.22	high_impact	5.13	0.85	neutral	0.08	damaging	4.06	23.70	deleterious	0.03	0.35	0.95	disease	0.83	disease	0.69	disease	0.66	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.43	medium_impact	3.46	high_impact	0.37	0.8	56.84	8.63	0.57	P	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15104	15104	C	G	MI.9093	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	358	120	L	V	Ctg/Gtg	-11.74	0	0	probably_damaging	0.99	neutral	0.27	neutral	2.66	deleterious	-3.01	deleterious	-2.55	high_impact	4.59	0.87	neutral	0.1	damaging	3.13	22.60	deleterious	0.16	0.45	0.67	disease	0.69	disease	0.59	disease	0.62	disease	2	1	deleterious	0.14	neutral	2	deleterious	0.80	deleterious	-2.59	low_impact	-0.01	medium_impact	2.97	high_impact	0.64	0.8	56.58	8.32	0.43	N	0.71	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15104	15104	C	A	MI.9094	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	358	120	L	M	Ctg/Atg	-11.74	0	0	probably_damaging	1	neutral	0.28	neutral	2.62	deleterious	-3.59	neutral	-1.64	high_impact	3.7	0.92	neutral	0.19	damaging	3.67	23.20	deleterious	0.13	0.4	0.74	disease	0.66	disease	0.38	neutral	0.33	neutral	3	1	deleterious	0.14	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0	medium_impact	2.17	high_impact	0.44	0.8	56.58	8.32	0.36	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15105	15105	T	C	MI.9095	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	359	120	L	P	cTg/cCg	-0.73	0	0	probably_damaging	1	deleterious	0.03	neutral	2.57	deleterious	-6.29	deleterious	-6.05	high_impact	5.14	0.87	neutral	0.06	damaging	3.83	23.40	deleterious	0.02	0.35	0.91	disease	0.88	disease	0.7	disease	0.62	disease	2	1	deleterious	0.02	neutral	6	deleterious	0.89	deleterious	-3.53	low_impact	-0.6	medium_impact	3.47	high_impact	0.44	0.8	56.58	8.32	0.59	P	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15105	15105	T	A	MI.9096	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	359	120	L	Q	cTg/cAg	-0.73	0	0	probably_damaging	1	deleterious	0.04	neutral	2.58	deleterious	-5.67	deleterious	-5.15	high_impact	5.14	0.86	neutral	0.07	damaging	4.10	23.70	deleterious	0.02	0.35	0.88	disease	0.84	disease	0.58	disease	0.63	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.53	low_impact	-0.53	medium_impact	3.47	high_impact	0.32	0.8	56.58	8.32	0.58	P	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15105	15105	T	G	MI.9097	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	359	120	L	R	cTg/cGg	-0.73	0	0	probably_damaging	1	deleterious	0.04	neutral	2.58	deleterious	-5.73	deleterious	-5.16	high_impact	5.14	0.87	neutral	0.06	damaging	4.10	23.70	deleterious	0.01	0.35	0.88	disease	0.93	disease	0.7	disease	0.65	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.92	deleterious	-3.53	low_impact	-0.53	medium_impact	3.47	high_impact	0.17	0.8	56.58	8.32	0.61	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15107	15107	C	T	MI.9098	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	361	121	L	F	Ctt/Ttt	-3.49	0	0	benign	0.03	neutral	0.42	neutral	2.87	neutral	-2.57	neutral	-0.94	neutral_impact	0.52	0.97	neutral	0.89	neutral	1.09	11.16	neutral	0.24	0.45	0.28	neutral	0.26	neutral	0.29	neutral	0.42	neutral	2	0.56	neutral	0.7	deleterious	-6	neutral	0.17	neutral	0.68	medium_impact	0.15	medium_impact	-0.72	medium_impact	0.44	0.8	17.89	17.41	0.43	N	0.17	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15107	15107	C	A	MI.9099	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	361	121	L	I	Ctt/Att	-3.49	0	0	benign	0.36	neutral	0.32	neutral	2.94	neutral	-1.91	neutral	-1.2	low_impact	1.86	0.91	neutral	0.7	neutral	2.68	20.70	deleterious	0.29	0.45	0.31	neutral	0.78	disease	0.3	neutral	0.2	neutral	6	0.62	neutral	0.48	deleterious	-6	neutral	0.30	neutral	-0.5	medium_impact	0.05	medium_impact	0.5	medium_impact	0.50	0.8	17.89	17.41	0.38	N	0.29	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8567	8567	T	A	MI.91	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	41	14	I	N	aTc/aAc	-4.27	0	0	probably_damaging	0.91	neutral	0.23	neutral	4.56	neutral	-1.01	deleterious	-3.91	low_impact	0.98	0.86	neutral	0.46	neutral	4.28	24.00	deleterious	0.35	0.65	0.27	neutral	0.66	disease	0.66	disease	0.69	disease	4	0.93	neutral	0.16	neutral	-2	neutral	0.63	deleterious	-1.71	low_impact	-0.01	medium_impact	-0.26	medium_impact	0.65	0.9	13.72	12.42	0.34	N	0.68	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8954	8954	T	G	MI.910	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	428	143	I	S	aTt/aGt	-0.33	0	0	probably_damaging	0.99	deleterious	0	neutral	4.2	neutral	-1.97	deleterious	-4.87	medium_impact	2.93	0.82	neutral	0.45	neutral	4.25	23.90	deleterious	0.2	0.65	0.68	disease	0.67	disease	0.63	disease	0.7	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-2.65	low_impact	-1.4	low_impact	1.41	medium_impact	0.63	0.9	19.47	13.18	0.33	N	0.74	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15107	15107	C	G	MI.9100	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	361	121	L	V	Ctt/Gtt	-3.49	0	0	benign	0.17	neutral	0.27	neutral	2.95	neutral	-1.79	neutral	-2.08	medium_impact	3.29	0.95	neutral	0.69	neutral	1.65	14.13	neutral	0.28	0.45	0.43	neutral	0.72	disease	0.46	neutral	0.35	neutral	3	0.68	neutral	0.55	deleterious	-3	neutral	0.27	neutral	-0.09	medium_impact	-0.01	medium_impact	1.79	medium_impact	0.58	0.8	17.89	17.41	0.35	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15108	15108	T	C	MI.9101	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	362	121	L	P	cTt/cCt	-0.73	0	0	probably_damaging	0.97	deleterious	0.03	neutral	2.76	deleterious	-4.7	deleterious	-5.41	high_impact	4.89	0.93	neutral	0.42	neutral	3.76	23.30	deleterious	0.03	0.35	0.84	disease	0.92	disease	0.67	disease	0.64	disease	3	1	deleterious	0.03	neutral	6	deleterious	0.88	deleterious	-2.14	low_impact	-0.6	medium_impact	3.25	high_impact	0.33	0.8	17.89	17.41	0.63	P	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15108	15108	T	G	MI.9102	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	362	121	L	R	cTt/cGt	-0.73	0	0	probably_damaging	0.9	neutral	0.05	neutral	2.77	deleterious	-3.88	deleterious	-4.54	high_impact	4.89	0.94	neutral	0.53	neutral	3.67	23.30	deleterious	0.02	0.35	0.79	disease	0.95	disease	0.67	disease	0.73	disease	5	0.98	deleterious	0.08	neutral	2	deleterious	0.86	deleterious	-1.62	low_impact	-0.47	medium_impact	3.25	high_impact	0.17	0.8	17.89	17.41	0.68	P	0.90	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15108	15108	T	A	MI.9103	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	362	121	L	H	cTt/cAt	-0.73	0	0	probably_damaging	0.95	neutral	0.08	neutral	2.76	deleterious	-4.67	deleterious	-4.64	high_impact	4.89	0.93	neutral	0.55	neutral	3.98	23.60	deleterious	0.04	0.35	0.84	disease	0.87	disease	0.63	disease	0.64	disease	3	0.99	deleterious	0.07	neutral	2	deleterious	0.82	deleterious	-1.92	low_impact	-0.35	medium_impact	3.25	high_impact	0.24	0.8	17.89	17.41	0.68	P	0.80	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15110	15110	G	C	MI.9104	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	364	122	A	P	Gca/Cca	-11.28	0	0.01	possibly_damaging	0.72	neutral	0.08	neutral	3.12	neutral	-2.24	neutral	-1.95	medium_impact	2.67	0.84	neutral	0.29	neutral	1.82	15.08	deleterious	0.05	0.35	0.64	disease	0.94	disease	0.63	disease	0.8	disease	6	0.94	neutral	0.18	neutral	0	NA	0.70	deleterious	-1.11	low_impact	-0.35	medium_impact	1.23	medium_impact	0.59	0.8	21.32	28.06	0.29	N	0.73	polymorphism	1	0.05	rs28357685	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15110	15110	G	T	MI.9105	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	364	122	A	S	Gca/Tca	-11.28	0	0.01	benign	0.32	neutral	0.11	neutral	3.14	neutral	-0.74	neutral	-0.74	low_impact	1.86	0.9	neutral	0.72	neutral	0.52	7.57	deleterious	0.29	0.45	0.42	neutral	0.66	disease	0.48	neutral	0.3	neutral	4	0.87	neutral	0.4	neutral	-6	neutral	0.28	neutral	-0.43	medium_impact	-0.27	medium_impact	0.5	medium_impact	0.52	0.8	21.32	28.06	0.43	N	0.61	polymorphism	1	0.02	rs28357685	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15110	15110	G	A	MI.9106	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	364	122	A	T	Gca/Aca	-11.28	0	0.01	benign	0.01	neutral	0.27	neutral	3.16	neutral	-0.21	neutral	0.04	neutral_impact	-0.31	0.99	neutral	0.95	neutral	-0.03	2.31	deleterious	0.18	0.45	0.16	neutral	0.36	neutral	0.29	neutral	0.43	neutral	1	0.72	neutral	0.63	deleterious	-6	neutral	0.11	neutral	1.13	medium_impact	-0.01	medium_impact	-1.48	low_impact	0.81	0.85	21.32	28.06	0.45	N	0.02	polymorphism	1	0.01	rs28357685	.	.	.	.	.	COSM1138299	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15111	15111	C	T	MI.9107	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	365	122	A	V	gCa/gTa	-3.49	0	0	benign	0.32	neutral	0.31	neutral	3.33	neutral	1.9	neutral	0.82	neutral_impact	0.66	0.92	neutral	0.68	neutral	1.11	11.25	neutral	0.17	0.45	0.14	neutral	0.79	disease	0.32	neutral	0.42	neutral	2	0.63	neutral	0.5	deleterious	-6	neutral	0.23	neutral	-0.43	medium_impact	0.03	medium_impact	-0.59	medium_impact	0.73	0.85	21.32	28.06	0.3	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	COSM1138300	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15111	15111	C	A	MI.9108	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	365	122	A	E	gCa/gAa	-3.49	0	0	possibly_damaging	0.52	neutral	0.11	neutral	3.12	neutral	-1.97	neutral	-1.92	medium_impact	2.67	0.82	neutral	0.43	neutral	2.40	18.84	deleterious	0.04	0.35	0.57	disease	0.91	disease	0.62	disease	0.76	disease	5	0.88	neutral	0.3	neutral	0	NA	0.46	deleterious	-0.76	medium_impact	-0.27	medium_impact	1.23	medium_impact	0.31	0.8	21.32	28.06	0.3	N	0.65	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15111	15111	C	G	MI.9109	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	365	122	A	G	gCa/gGa	-3.49	0	0	benign	0.32	neutral	0.29	neutral	3.12	neutral	-1.74	deleterious	-2.56	medium_impact	2.67	0.82	neutral	0.5	neutral	1.97	16.04	deleterious	0.26	0.45	0.57	disease	0.73	disease	0.48	neutral	0.44	neutral	1	0.65	neutral	0.49	deleterious	-3	neutral	0.36	neutral	-0.43	medium_impact	0.01	medium_impact	1.23	medium_impact	0.66	0.8	21.32	28.06	0.29	N	0.54	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8955	8955	T	A	MI.911	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	429	143	I	M	atT/atA	3.83	0.45	0	probably_damaging	1	neutral	0.18	neutral	4.22	neutral	-2.18	neutral	-1.87	low_impact	1.28	0.9	neutral	0.95	neutral	2.56	19.85	deleterious	0.4	0.65	0.62	disease	0.23	neutral	0.38	neutral	0.55	disease	1	1	deleterious	0.09	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	-0.08	medium_impact	0	medium_impact	0.74	0.9	19.47	13.18	0.5	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15113	15113	A	G	MI.9110	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	367	123	T	A	Act/Gct	-4.4	0	0	probably_damaging	1	neutral	0.49	neutral	2.99	neutral	-1.06	neutral	-1.06	medium_impact	2.34	0.98	neutral	0.74	neutral	3.06	22.40	deleterious	0.25	0.45	0.41	neutral	0.76	disease	0.46	neutral	0.49	neutral	0	1	deleterious	0.25	neutral	1	deleterious	0.71	deleterious	-3.53	low_impact	0.21	medium_impact	0.93	medium_impact	0.37	0.8	15	16.14	0.33	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15113	15113	A	T	MI.9111	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	367	123	T	S	Act/Tct	-4.4	0	0	probably_damaging	1	neutral	0.2	neutral	2.97	neutral	-2.2	neutral	-2.01	low_impact	1.4	0.94	neutral	0.61	neutral	3.00	22.20	deleterious	0.38	0.5	0.52	disease	0.78	disease	0.37	neutral	0.43	neutral	1	1	deleterious	0.1	neutral	-2	neutral	0.76	deleterious	-3.53	low_impact	-0.1	medium_impact	0.08	medium_impact	0.55	0.8	15	16.14	0.35	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15113	15113	A	C	MI.9112	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	367	123	T	P	Act/Cct	-4.4	0	0	probably_damaging	1	neutral	0.13	neutral	2.88	deleterious	-4.64	deleterious	-2.63	high_impact	4.08	0.94	neutral	0.43	neutral	3.29	22.80	deleterious	0.05	0.35	0.73	disease	0.96	disease	0.64	disease	0.77	disease	5	1	deleterious	0.07	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.23	medium_impact	2.51	high_impact	0.30	0.8	15	16.14	0.44	N	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15114	15114	C	A	MI.9113	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	368	123	T	N	aCt/aAt	-0.5	0	0	probably_damaging	1	neutral	0.1	neutral	2.88	deleterious	-4.25	deleterious	-2.92	high_impact	3.73	0.93	neutral	0.62	neutral	3.49	23.10	deleterious	0.25	0.45	0.69	disease	0.91	disease	0.59	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.3	medium_impact	2.19	high_impact	0.53	0.8	15	16.14	0.44	N	0.87	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15114	15114	C	T	MI.9114	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	368	123	T	I	aCt/aTt	-0.5	0	0	probably_damaging	1	neutral	0.59	neutral	2.99	neutral	-2.01	neutral	0.68	low_impact	1.73	0.94	neutral	0.84	neutral	3.59	23.20	deleterious	0.15	0.4	0.31	neutral	0.91	disease	0.4	neutral	0.2	neutral	6	1	deleterious	0.3	neutral	-2	neutral	0.75	deleterious	-3.53	low_impact	0.31	medium_impact	0.38	medium_impact	0.68	0.85	15	16.14	0.25	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15114	15114	C	G	MI.9115	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	368	123	T	S	aCt/aGt	-0.5	0	0	probably_damaging	1	neutral	0.2	neutral	2.97	neutral	-2.2	neutral	-2.01	low_impact	1.4	0.94	neutral	0.61	neutral	3.12	22.60	deleterious	0.38	0.5	0.52	disease	0.78	disease	0.37	neutral	0.43	neutral	1	1	deleterious	0.1	neutral	-2	neutral	0.76	deleterious	-3.53	low_impact	-0.1	medium_impact	0.08	medium_impact	0.55	0.8	15	16.14	0.36	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15116	15116	A	C	MI.9116	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	370	124	M	L	Ata/Cta	-20	0	0	probably_damaging	0.93	neutral	0.98	neutral	3.24	neutral	0.33	deleterious	-2.67	high_impact	4.46	0.94	neutral	0.08	damaging	1.41	12.83	neutral	0.32	0.5	0.3	neutral	0.9	disease	0.67	disease	0.7	disease	4	0.93	neutral	0.53	deleterious	2	deleterious	0.75	deleterious	-1.78	low_impact	1.14	medium_impact	2.86	high_impact	0.30	0.8	58.42	8.65	0.32	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15116	15116	A	G	MI.9117	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	370	124	M	V	Ata/Gta	-20	0	0	probably_damaging	0.96	neutral	0.81	neutral	3.04	neutral	-1.38	deleterious	-3.56	high_impact	4.29	0.93	neutral	0.14	damaging	0.94	10.32	neutral	0.27	0.45	0.37	neutral	0.9	disease	0.67	disease	0.69	disease	4	0.95	neutral	0.43	neutral	2	deleterious	0.80	deleterious	-2.02	low_impact	0.56	medium_impact	2.7	high_impact	0.37	0.8	58.42	8.65	0.29	N	0.98	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15116	15116	A	T	MI.9118	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	370	124	M	L	Ata/Tta	-20	0	0	probably_damaging	0.93	neutral	0.98	neutral	3.24	neutral	0.33	deleterious	-2.67	high_impact	4.46	0.94	neutral	0.08	damaging	1.59	13.81	neutral	0.32	0.5	0.3	neutral	0.9	disease	0.67	disease	0.7	disease	4	0.93	neutral	0.53	deleterious	2	deleterious	0.75	deleterious	-1.78	low_impact	1.14	medium_impact	2.86	high_impact	0.30	0.8	58.42	8.65	0.32	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15117	15117	T	A	MI.9119	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	371	124	M	K	aTa/aAa	6.84	1	0	probably_damaging	0.98	neutral	0.09	neutral	2.91	deleterious	-3.97	deleterious	-5.35	high_impact	4.54	0.93	neutral	0.08	damaging	2.08	16.72	deleterious	0.04	0.35	0.88	disease	0.95	disease	0.76	disease	0.65	disease	3	0.99	deleterious	0.06	neutral	2	deleterious	0.90	deleterious	-2.31	low_impact	-0.32	medium_impact	2.93	high_impact	0.15	0.8	58.42	8.65	0.64	P	0.99	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8955	8955	T	G	MI.912	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	429	143	I	M	atT/atG	3.83	0.45	0	probably_damaging	1	neutral	0.18	neutral	4.22	neutral	-2.18	neutral	-1.87	low_impact	1.28	0.9	neutral	0.95	neutral	2.24	17.75	deleterious	0.4	0.65	0.62	disease	0.23	neutral	0.38	neutral	0.55	disease	1	1	deleterious	0.09	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	-0.08	medium_impact	0	medium_impact	0.74	0.9	19.47	13.18	0.49	N	0.73	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15117	15117	T	C	MI.9120	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	371	124	M	T	aTa/aCa	6.84	1	0	probably_damaging	0.99	neutral	0.45	neutral	2.95	neutral	-2.63	deleterious	-5.34	high_impact	4.75	0.93	neutral	0.11	damaging	1.24	11.94	neutral	0.09	0.35	0.74	disease	0.89	disease	0.7	disease	0.69	disease	4	0.99	deleterious	0.23	neutral	2	deleterious	0.88	deleterious	-2.59	low_impact	0.18	medium_impact	3.12	high_impact	0.16	0.8	58.42	8.65	0.7	P	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15118	15118	A	T	MI.9121	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	372	124	M	I	atA/atT	4.54	1	0	probably_damaging	0.97	neutral	0.4	neutral	3.03	neutral	-0.97	deleterious	-3.56	medium_impact	3.22	0.93	neutral	0.09	damaging	1.63	14.02	neutral	0.26	0.45	0.15	neutral	0.9	disease	0.58	disease	0.53	disease	1	0.97	neutral	0.22	neutral	1	deleterious	0.75	deleterious	-2.14	low_impact	0.13	medium_impact	1.73	medium_impact	0.38	0.8	58.42	8.65	0.46	N	0.95	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15118	15118	A	C	MI.9122	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	372	124	M	I	atA/atC	4.54	1	0	probably_damaging	0.97	neutral	0.4	neutral	3.03	neutral	-0.97	deleterious	-3.56	medium_impact	3.22	0.93	neutral	0.09	damaging	1.54	13.51	neutral	0.26	0.45	0.15	neutral	0.9	disease	0.58	disease	0.53	disease	1	0.97	neutral	0.22	neutral	1	deleterious	0.75	deleterious	-2.14	low_impact	0.13	medium_impact	1.73	medium_impact	0.38	0.8	58.42	8.65	0.44	N	0.95	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15119	15119	G	T	MI.9123	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	373	125	A	S	Gca/Tca	1.56	1	0.01	benign	0.26	neutral	0.22	neutral	3.01	neutral	-2.47	neutral	-1.8	high_impact	4.37	0.94	neutral	0.47	neutral	3.29	22.80	deleterious	0.23	0.45	0.57	disease	0.86	disease	0.55	disease	0.63	disease	3	0.74	neutral	0.48	deleterious	-2	neutral	0.33	neutral	-0.31	medium_impact	-0.08	medium_impact	2.77	high_impact	0.52	0.8	16.58	12.85	0.5	N	0.55	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15119	15119	G	C	MI.9124	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	373	125	A	P	Gca/Cca	1.56	1	0.01	possibly_damaging	0.66	neutral	0.23	neutral	2.96	deleterious	-4.51	deleterious	-3.32	high_impact	5.05	0.94	neutral	0.28	neutral	3.63	23.20	deleterious	0.03	0.35	0.77	disease	0.94	disease	0.71	disease	0.76	disease	5	0.8	neutral	0.29	neutral	1	deleterious	0.79	deleterious	-1	medium_impact	-0.06	medium_impact	3.39	high_impact	0.56	0.8	16.58	12.85	0.66	P	0.83	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15119	15119	G	A	MI.9125	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	373	125	A	T	Gca/Aca	1.56	1	0.01	benign	0.01	neutral	0.32	neutral	3.02	neutral	-2.13	neutral	-2.25	high_impact	3.56	0.96	neutral	0.52	neutral	3.82	23.40	deleterious	0.13	0.4	0.5	disease	0.82	disease	0.5	neutral	0.43	neutral	1	0.67	neutral	0.66	deleterious	-2	neutral	0.26	neutral	1.13	medium_impact	0.05	medium_impact	2.04	high_impact	0.61	0.8	16.58	12.85	0.51	P	0.32	polymorphism	1	0.03	rs201194402	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15120	15120	C	G	MI.9126	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	374	125	A	G	gCa/gGa	3.17	1	0	benign	0.16	neutral	0.34	neutral	3.16	neutral	-0.7	deleterious	-2.92	medium_impact	2.15	0.96	neutral	0.53	neutral	2.11	16.90	deleterious	0.2	0.45	0.61	disease	0.82	disease	0.37	neutral	0.2	neutral	6	0.6	neutral	0.59	deleterious	-3	neutral	0.33	neutral	-0.06	medium_impact	0.07	medium_impact	0.76	medium_impact	0.73	0.85	16.58	12.85	0.46	N	0.58	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15120	15120	C	A	MI.9127	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	374	125	A	E	gCa/gAa	3.17	1	0	possibly_damaging	0.68	neutral	0.13	neutral	2.97	deleterious	-3.91	deleterious	-3.31	high_impact	5.05	0.93	neutral	0.4	neutral	4.34	24.00	deleterious	0.04	0.35	0.71	disease	0.94	disease	0.68	disease	0.75	disease	5	0.89	neutral	0.23	neutral	1	deleterious	0.68	deleterious	-1.04	low_impact	-0.23	medium_impact	3.39	high_impact	0.39	0.8	16.58	12.85	0.68	P	0.87	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15120	15120	C	T	MI.9128	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	374	125	A	V	gCa/gTa	3.17	1	0	benign	0.18	neutral	0.42	neutral	3.12	neutral	-0.8	neutral	-1.95	medium_impact	3.04	0.95	neutral	0.5	neutral	4.00	23.60	deleterious	0.11	0.4	0.22	neutral	0.88	disease	0.41	neutral	0.18	neutral	6	0.5	neutral	0.62	deleterious	-3	neutral	0.35	neutral	-0.12	medium_impact	0.15	medium_impact	1.57	medium_impact	0.57	0.8	16.58	12.85	0.52	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15122	15122	A	G	MI.9129	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	376	126	T	A	Aca/Gca	-7.61	0	0	probably_damaging	0.99	neutral	0.57	neutral	3.14	neutral	-0.33	deleterious	-4.27	medium_impact	3.25	0.9	neutral	0.57	neutral	1.70	14.40	neutral	0.12	0.4	0.55	disease	0.7	disease	0.49	neutral	0.45	neutral	1	0.99	deleterious	0.29	neutral	1	deleterious	0.21	neutral	-2.59	low_impact	0.29	medium_impact	1.76	medium_impact	0.30	0.8	55.79	8.73	0.27	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8956	8956	A	T	MI.913	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	430	144	I	F	Atc/Ttc	-4.27	0	0	probably_damaging	0.99	deleterious	0	neutral	3.9	deleterious	-5.06	deleterious	-3.68	high_impact	3.83	0.78	neutral	0.12	damaging	3.79	23.40	deleterious	0.25	0.65	0.73	disease	0.71	disease	0.73	disease	0.72	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.65	low_impact	-1.4	low_impact	2.19	high_impact	0.74	0.9	49.12	8.59	0.31	N	0.97	disease_causing	0.98	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15122	15122	A	T	MI.9130	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	376	126	T	S	Aca/Tca	-7.61	0	0	probably_damaging	0.99	neutral	0.39	neutral	3.03	neutral	-2.02	deleterious	-3.44	high_impact	3.73	0.93	neutral	0.49	neutral	1.72	14.50	neutral	0.21	0.45	0.59	disease	0.75	disease	0.57	disease	0.64	disease	3	0.99	deleterious	0.2	neutral	2	deleterious	0.28	neutral	-2.59	low_impact	0.12	medium_impact	2.19	high_impact	0.41	0.8	55.79	8.73	0.37	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15122	15122	A	C	MI.9131	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	376	126	T	P	Aca/Cca	-7.61	0	0	probably_damaging	1	neutral	0.22	neutral	2.97	deleterious	-3.66	deleterious	-5.19	high_impact	5.39	0.93	neutral	0.32	neutral	3.30	22.90	deleterious	0.05	0.35	0.83	disease	0.86	disease	0.75	disease	0.66	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.71	deleterious	-3.53	low_impact	-0.08	medium_impact	3.7	high_impact	0.28	0.8	55.79	8.73	0.72	P	0.95	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15123	15123	C	A	MI.9132	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	377	126	T	K	aCa/aAa	8.44	1	0	probably_damaging	1	neutral	0.28	neutral	3.02	neutral	-2.3	deleterious	-5.2	high_impact	5.39	0.94	neutral	0.37	neutral	4.15	23.80	deleterious	0.08	0.35	0.68	disease	0.9	disease	0.74	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.62	deleterious	-3.53	low_impact	0	medium_impact	3.7	high_impact	0.34	0.8	55.79	8.73	0.79	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15123	15123	C	T	MI.9133	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	377	126	T	M	aCa/aTa	8.44	1	0	probably_damaging	1	neutral	0.26	neutral	3.01	neutral	-1.73	deleterious	-5.2	high_impact	5.05	0.94	neutral	0.44	neutral	3.85	23.40	deleterious	0.09	0.35	0.86	disease	0.86	disease	0.66	disease	0.63	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.02	medium_impact	3.39	high_impact	0.37	0.8	55.79	8.73	0.75	P	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15125	15125	G	A	MI.9134	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	379	127	A	T	Gcc/Acc	-5.32	0	0	probably_damaging	1	neutral	0.48	neutral	2.74	deleterious	-3.64	deleterious	-3.49	high_impact	4.92	0.96	neutral	0.13	damaging	4.07	23.70	deleterious	0.09	0.35	0.76	disease	0.81	disease	0.65	disease	0.66	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.2	medium_impact	3.27	high_impact	0.80	0.85	57.63	8.8	0.69	P	0.79	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15125	15125	G	T	MI.9135	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	379	127	A	S	Gcc/Tcc	-5.32	0	0	probably_damaging	1	neutral	0.41	neutral	2.95	neutral	-1.23	deleterious	-2.62	high_impact	4	0.94	neutral	0.1	damaging	3.53	23.10	deleterious	0.15	0.4	0.7	disease	0.81	disease	0.58	disease	0.65	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.14	medium_impact	2.44	high_impact	0.56	0.8	57.63	8.8	0.32	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15125	15125	G	C	MI.9136	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	379	127	A	P	Gcc/Ccc	-5.32	0	0	probably_damaging	1	neutral	0.21	neutral	2.71	deleterious	-5.16	deleterious	-4.37	high_impact	5.47	0.95	neutral	0.05	damaging	3.73	23.30	deleterious	0.03	0.35	0.88	disease	0.87	disease	0.76	disease	0.61	disease	2	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.09	medium_impact	3.77	high_impact	0.52	0.8	57.63	8.8	0.72	P	0.98	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15126	15126	C	T	MI.9137	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	380	127	A	V	gCc/gTc	5.92	1	0	probably_damaging	1	neutral	0.52	neutral	2.76	deleterious	-3.03	deleterious	-3.49	high_impact	4.92	0.97	neutral	0.13	damaging	4.27	24.00	deleterious	0.07	0.35	0.85	disease	0.85	disease	0.6	disease	0.62	disease	2	1	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.24	medium_impact	3.27	high_impact	0.75	0.85	57.63	8.8	0.78	P	0.84	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15126	15126	C	G	MI.9138	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	380	127	A	G	gCc/gGc	5.92	1	0	probably_damaging	1	neutral	0.35	neutral	3.16	neutral	-0.08	deleterious	-3.49	high_impact	3.77	0.95	neutral	0.14	damaging	3.61	23.20	deleterious	0.14	0.4	0.66	disease	0.77	disease	0.57	disease	0.65	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.08	medium_impact	2.23	high_impact	0.63	0.8	57.63	8.8	0.53	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15126	15126	C	A	MI.9139	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	380	127	A	D	gCc/gAc	5.92	1	0	probably_damaging	1	neutral	0.2	neutral	2.71	deleterious	-5.15	deleterious	-5.24	high_impact	5.47	0.93	neutral	0.08	damaging	4.54	24.30	deleterious	0.03	0.35	0.91	disease	0.91	disease	0.74	disease	0.62	disease	2	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.1	medium_impact	3.77	high_impact	0.29	0.8	57.63	8.8	0.76	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8956	8956	A	G	MI.914	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	430	144	I	V	Atc/Gtc	-4.27	0	0	probably_damaging	0.93	neutral	0.14	neutral	3.99	neutral	-2.84	neutral	-0.92	medium_impact	2.08	0.85	neutral	0.21	damaging	3.03	22.30	deleterious	0.46	0.65	0.64	disease	0.39	neutral	0.62	disease	0.57	disease	1	0.97	neutral	0.11	neutral	1	deleterious	0.68	deleterious	-1.82	low_impact	-0.15	medium_impact	0.69	medium_impact	0.63	0.9	49.12	8.59	0.34	N	0.77	polymorphism	0.84	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15128	15128	T	C	MI.9140	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	382	128	F	L	Ttc/Ctc	-6.93	0	0	benign	0.01	neutral	0.66	neutral	2.77	deleterious	-3.54	deleterious	-5.25	high_impact	4	0.95	neutral	0.11	damaging	3.59	23.20	deleterious	0.08	0.35	0.49	neutral	0.79	disease	0.68	disease	0.66	disease	3	0.31	neutral	0.83	deleterious	-2	neutral	0.24	neutral	1.13	medium_impact	0.38	medium_impact	2.44	high_impact	0.51	0.8	58.16	8.74	0.23	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15128	15128	T	G	MI.9141	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	382	128	F	V	Ttc/Gtc	-6.93	0	0	possibly_damaging	0.55	neutral	0.51	neutral	2.8	deleterious	-4.18	deleterious	-6.13	high_impact	4.8	0.95	neutral	0.11	damaging	3.97	23.60	deleterious	0.08	0.35	0.79	disease	0.84	disease	0.74	disease	0.69	disease	4	0.53	neutral	0.48	deleterious	1	deleterious	0.59	deleterious	-0.81	medium_impact	0.23	medium_impact	3.17	high_impact	0.26	0.8	58.16	8.74	0.6	P	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15128	15128	T	A	MI.9142	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	382	128	F	I	Ttc/Atc	-6.93	0	0	benign	0.25	neutral	0.4	neutral	2.77	deleterious	-3.86	deleterious	-5.25	high_impact	5.5	0.94	neutral	0.12	damaging	4.13	23.80	deleterious	0.08	0.35	0.76	disease	0.83	disease	0.71	disease	0.67	disease	3	0.52	neutral	0.58	deleterious	-2	neutral	0.54	deleterious	-0.29	medium_impact	0.13	medium_impact	3.8	high_impact	0.36	0.8	58.16	8.74	0.59	P	0.97	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15129	15129	T	A	MI.9143	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	383	128	F	Y	tTc/tAc	7.3	1	0	possibly_damaging	0.6	neutral	1	neutral	2.7	deleterious	-3.28	deleterious	-2.63	high_impact	5.5	0.95	neutral	0.11	damaging	3.76	23.30	deleterious	0.1	0.4	0.62	disease	0.76	disease	0.71	disease	0.68	disease	4	0.6	neutral	0.7	deleterious	1	deleterious	0.67	deleterious	-0.9	medium_impact	1.85	high_impact	3.8	high_impact	0.48	0.8	58.16	8.74	0.7	P	0.87	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15129	15129	T	C	MI.9144	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	383	128	F	S	tTc/tCc	7.3	1	0	possibly_damaging	0.9	neutral	0.4	neutral	2.67	deleterious	-6.5	deleterious	-7.01	high_impact	4.69	0.93	neutral	0.08	damaging	4.09	23.70	deleterious	0.03	0.35	0.91	disease	0.82	disease	0.72	disease	0.62	disease	2	0.9	neutral	0.25	neutral	1	deleterious	0.80	deleterious	-1.62	low_impact	0.13	medium_impact	3.07	high_impact	0.27	0.8	58.16	8.74	0.64	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15129	15129	T	G	MI.9145	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	383	128	F	C	tTc/tGc	7.3	1	0	probably_damaging	0.98	neutral	0.17	neutral	2.64	deleterious	-7.74	deleterious	-7.01	high_impact	5.5	0.95	neutral	0.09	damaging	4.02	23.60	deleterious	0.04	0.35	0.96	disease	0.85	disease	0.76	disease	0.64	disease	3	0.99	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-2.31	low_impact	-0.15	medium_impact	3.8	high_impact	0.26	0.8	58.16	8.74	0.66	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15130	15130	C	A	MI.9146	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	384	128	F	L	ttC/ttA	5.69	1	0.01	benign	0.01	neutral	0.66	neutral	2.77	deleterious	-3.54	deleterious	-5.25	high_impact	4	0.95	neutral	0.11	damaging	4.24	23.90	deleterious	0.08	0.35	0.49	neutral	0.79	disease	0.68	disease	0.66	disease	3	0.31	neutral	0.83	deleterious	-2	neutral	0.24	neutral	1.13	medium_impact	0.38	medium_impact	2.44	high_impact	0.51	0.8	58.16	8.74	0.49	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15130	15130	C	G	MI.9147	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	384	128	F	L	ttC/ttG	5.69	1	0.01	benign	0.01	neutral	0.66	neutral	2.77	deleterious	-3.54	deleterious	-5.25	high_impact	4	0.95	neutral	0.11	damaging	3.87	23.50	deleterious	0.08	0.35	0.49	neutral	0.79	disease	0.68	disease	0.66	disease	3	0.31	neutral	0.83	deleterious	-2	neutral	0.24	neutral	1.13	medium_impact	0.38	medium_impact	2.44	high_impact	0.51	0.8	58.16	8.74	0.49	N	0.92	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15131	15131	A	C	MI.9148	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	385	129	M	L	Ata/Cta	-2.8	0	0	probably_damaging	0.96	neutral	0.69	neutral	3.35	neutral	0.82	neutral	-0.76	neutral_impact	0.33	0.94	neutral	0.4	neutral	0.33	5.97	deleterious	0.19	0.45	0.14	neutral	0.81	disease	0.45	neutral	0.19	neutral	6	0.95	neutral	0.37	neutral	-2	neutral	0.67	deleterious	-2.02	low_impact	0.41	medium_impact	-0.89	medium_impact	0.22	0.8	38.68	11.42	0.21	N	0.78	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15131	15131	A	G	MI.9149	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	385	129	M	V	Ata/Gta	-2.8	0	0	probably_damaging	0.98	neutral	0.77	neutral	3.23	neutral	-0.13	neutral	0.24	neutral_impact	-0.28	0.98	neutral	0.67	neutral	-1.20	0.01	neutral	0.18	0.45	0.24	neutral	0.2	neutral	0.45	neutral	0.34	neutral	3	0.97	neutral	0.4	neutral	-2	neutral	0.66	deleterious	-2.31	low_impact	0.51	medium_impact	-1.45	low_impact	0.23	0.8	38.68	11.42	0.33	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8956	8956	A	C	MI.915	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	430	144	I	L	Atc/Ctc	-4.27	0	0	probably_damaging	0.93	neutral	0.06	neutral	4.34	neutral	-1.96	neutral	-1.84	medium_impact	3.08	0.8	neutral	0.12	damaging	3.83	23.40	deleterious	0.3	0.65	0.25	neutral	0.58	disease	0.65	disease	0.65	disease	3	0.98	deleterious	0.07	neutral	1	deleterious	0.63	deleterious	-1.82	low_impact	-0.38	medium_impact	1.54	medium_impact	0.66	0.9	49.12	8.59	0.33	N	0.83	polymorphism	0.69	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15131	15131	A	T	MI.9150	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	385	129	M	L	Ata/Tta	-2.8	0	0	probably_damaging	0.96	neutral	0.69	neutral	3.35	neutral	0.82	neutral	-0.76	neutral_impact	0.33	0.94	neutral	0.4	neutral	0.40	6.57	deleterious	0.19	0.45	0.14	neutral	0.81	disease	0.45	neutral	0.19	neutral	6	0.95	neutral	0.37	neutral	-2	neutral	0.67	deleterious	-2.02	low_impact	0.41	medium_impact	-0.89	medium_impact	0.22	0.8	38.68	11.42	0.21	N	0.78	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15132	15132	T	A	MI.9151	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	386	129	M	K	aTa/aAa	0.87	0.74	0	probably_damaging	0.99	neutral	0.24	neutral	3.09	neutral	-2.38	deleterious	-3.6	high_impact	4.27	0.93	neutral	0.37	neutral	2.21	17.56	deleterious	0.03	0.35	0.7	disease	0.92	disease	0.77	disease	0.74	disease	5	0.99	deleterious	0.13	neutral	2	deleterious	0.87	deleterious	-2.59	low_impact	-0.05	medium_impact	2.68	high_impact	0.15	0.8	38.68	11.42	0.49	N	0.98	disease_causing	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15132	15132	T	C	MI.9152	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	386	129	M	T	aTa/aCa	0.87	0.74	0	probably_damaging	1	neutral	0.35	neutral	3.27	neutral	1.74	deleterious	-2.51	medium_impact	2.92	0.9	neutral	0.49	neutral	2.51	19.53	deleterious	0.08	0.35	0.51	disease	0.82	disease	0.63	disease	0.69	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.82	deleterious	-3.53	low_impact	0.08	medium_impact	1.46	medium_impact	0.18	0.8	38.68	11.42	0.32	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15133	15133	A	C	MI.9153	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	387	129	M	I	atA/atC	7.3	0.98	0	probably_damaging	0.98	neutral	0.41	neutral	3.16	neutral	-0.33	neutral	-0.19	medium_impact	2.4	0.96	neutral	0.43	neutral	1.61	13.89	neutral	0.21	0.45	0.19	neutral	0.85	disease	0.54	disease	0.51	disease	0	0.98	deleterious	0.22	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	0.14	medium_impact	0.99	medium_impact	0.28	0.8	38.68	11.42	0.54	N	0.88	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15133	15133	A	T	MI.9154	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	387	129	M	I	atA/atT	7.3	0.98	0	probably_damaging	0.98	neutral	0.41	neutral	3.16	neutral	-0.33	neutral	-0.19	medium_impact	2.4	0.96	neutral	0.43	neutral	1.73	14.60	neutral	0.21	0.45	0.19	neutral	0.85	disease	0.54	disease	0.51	disease	0	0.98	deleterious	0.22	neutral	1	deleterious	0.75	deleterious	-2.31	low_impact	0.14	medium_impact	0.99	medium_impact	0.28	0.8	38.68	11.42	0.57	P	0.88	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15134	15134	G	A	MI.9155	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	388	130	G	S	Ggc/Agc	-4.86	0	0	probably_damaging	1	neutral	0.4	neutral	1.12	deleterious	-8.62	deleterious	-5.2	high_impact	4.7	0.82	neutral	0.05	damaging	4.06	23.70	deleterious	0.04	0.35	0.92	disease	0.82	disease	0.67	disease	0.61	disease	2	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.13	medium_impact	3.07	high_impact	0.68	0.85	58.68	8.89	0.54	N	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15134	15134	G	T	MI.9156	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	388	130	G	C	Ggc/Tgc	-4.86	0	0	probably_damaging	1	neutral	0.18	neutral	1.08	deleterious	-11.62	deleterious	-7.8	high_impact	5.5	0.84	neutral	0.03	damaging	4.02	23.60	deleterious	0.02	0.35	0.97	disease	0.9	disease	0.68	disease	0.65	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.14	medium_impact	3.8	high_impact	0.24	0.8	58.68	8.89	0.51	N	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15134	15134	G	C	MI.9157	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	388	130	G	R	Ggc/Cgc	-4.86	0	0	probably_damaging	1	neutral	0.35	neutral	1.08	deleterious	-10.01	deleterious	-6.94	high_impact	4.8	0.83	neutral	0.04	damaging	3.80	23.40	deleterious	0.02	0.35	0.96	disease	0.9	disease	0.77	disease	0.6	disease	2	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.08	medium_impact	3.17	high_impact	0.58	0.8	58.68	8.89	0.63	P	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15135	15135	G	C	MI.9158	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	389	130	G	A	gGc/gCc	7.3	1	0	probably_damaging	1	neutral	0.51	neutral	1.13	deleterious	-7.45	deleterious	-5.2	high_impact	4.95	0.84	neutral	0.1	damaging	2.97	22.10	deleterious	0.04	0.35	0.9	disease	0.72	disease	0.65	disease	0.64	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.23	medium_impact	3.3	high_impact	0.51	0.8	58.68	8.89	0.7	P	0.83	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15135	15135	G	T	MI.9159	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	389	130	G	V	gGc/gTc	7.3	1	0	probably_damaging	1	neutral	0.5	neutral	1.09	deleterious	-10.85	deleterious	-7.8	high_impact	5.15	0.84	neutral	0.07	damaging	3.66	23.20	deleterious	0.02	0.35	0.96	disease	0.88	disease	0.68	disease	0.6	disease	2	1	deleterious	0.25	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.22	medium_impact	3.48	high_impact	0.23	0.8	58.68	8.89	0.6	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8957	8957	T	A	MI.916	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	431	144	I	N	aTc/aAc	8.69	1	0	probably_damaging	1	deleterious	0.02	neutral	3.82	deleterious	-7.57	deleterious	-6.44	high_impact	4.17	0.86	neutral	0.15	damaging	4.37	24.10	deleterious	0.2	0.65	0.98	disease	0.73	disease	0.72	disease	0.83	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-3.6	low_impact	-0.66	medium_impact	2.48	high_impact	0.48	0.9	49.12	8.59	0.53	P	1.00	disease_causing	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15135	15135	G	A	MI.9160	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	389	130	G	D	gGc/gAc	7.3	1	0	probably_damaging	1	neutral	0.2	neutral	1.09	deleterious	-9.22	deleterious	-6.07	high_impact	4.61	0.79	neutral	0.05	damaging	3.77	23.40	deleterious	0.02	0.35	0.95	disease	0.88	disease	0.76	disease	0.61	disease	2	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.1	medium_impact	2.99	high_impact	0.17	0.8	58.68	8.89	0.54	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15137	15137	T	A	MI.9161	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	391	131	Y	N	Tat/Aat	-12.2	0	0	probably_damaging	1	neutral	0.3	neutral	2.53	deleterious	-6.76	deleterious	-7.79	high_impact	4.36	0.86	neutral	0.09	damaging	3.90	23.50	deleterious	0.06	0.35	0.94	disease	0.85	disease	0.72	disease	0.62	disease	2	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.02	medium_impact	2.77	high_impact	0.12	0.8	56.84	8.83	0.43	N	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15137	15137	T	G	MI.9162	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	391	131	Y	D	Tat/Gat	-12.2	0	0	probably_damaging	1	neutral	0.2	neutral	2.54	deleterious	-7.62	deleterious	-8.66	high_impact	5.16	0.84	neutral	0.07	damaging	3.83	23.40	deleterious	0.03	0.35	0.96	disease	0.87	disease	0.8	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.1	medium_impact	3.49	high_impact	0.20	0.8	56.84	8.83	0.61	P	1.00	disease_causing	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15137	15137	T	C	MI.9163	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	391	131	Y	H	Tat/Cat	-12.2	0	0	probably_damaging	1	neutral	0.53	neutral	2.52	deleterious	-5.71	deleterious	-4.33	high_impact	4.81	0.9	neutral	0.08	damaging	3.38	22.90	deleterious	0.13	0.4	0.9	disease	0.8	disease	0.79	disease	0.66	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.25	medium_impact	3.17	high_impact	0.18	0.8	56.84	8.83	0.67	P	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15138	15138	A	G	MI.9164	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	392	131	Y	C	tAt/tGt	5.69	1	0	probably_damaging	1	neutral	0.17	neutral	2.51	deleterious	-7.62	deleterious	-7.8	high_impact	5.5	0.86	neutral	0.05	damaging	3.46	23.00	deleterious	0.05	0.35	0.97	disease	0.88	disease	0.76	disease	0.65	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.15	medium_impact	3.8	high_impact	0.14	0.8	56.84	8.83	0.63	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15138	15138	A	C	MI.9165	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	392	131	Y	S	tAt/tCt	5.69	1	0	probably_damaging	1	neutral	0.4	neutral	2.55	deleterious	-6.69	deleterious	-7.79	high_impact	5.16	0.89	neutral	0.09	damaging	3.62	23.20	deleterious	0.06	0.35	0.93	disease	0.84	disease	0.71	disease	0.63	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.13	medium_impact	3.49	high_impact	0.20	0.8	56.84	8.83	0.66	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15138	15138	A	T	MI.9166	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	392	131	Y	F	tAt/tTt	5.69	1	0	probably_damaging	0.99	neutral	0.69	neutral	2.54	deleterious	-4.03	deleterious	-3.46	high_impact	5.16	0.91	neutral	0.08	damaging	1.73	14.58	neutral	0.14	0.4	0.7	disease	0.82	disease	0.67	disease	0.66	disease	3	0.99	deleterious	0.35	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	0.41	medium_impact	3.49	high_impact	0.43	0.8	56.84	8.83	0.73	P	0.83	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15140	15140	G	A	MI.9167	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	394	132	V	I	Gtc/Atc	-5.78	0	0.01	probably_damaging	0.99	neutral	0.31	neutral	3	neutral	-1.17	neutral	-0.8	medium_impact	2.68	0.82	neutral	0.53	neutral	1.85	15.31	deleterious	0.37	0.5	0.4	neutral	0.64	disease	0.44	neutral	0.34	neutral	3	0.99	deleterious	0.16	neutral	1	deleterious	0.70	deleterious	-2.59	low_impact	0.03	medium_impact	1.24	medium_impact	0.83	0.85	55.53	8.57	0.33	N	0.34	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15140	15140	G	T	MI.9168	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	394	132	V	F	Gtc/Ttc	-5.78	0	0.01	probably_damaging	1	neutral	0.7	neutral	2.89	deleterious	-3.05	deleterious	-4.24	high_impact	4.75	0.9	neutral	0.43	neutral	3.71	23.30	deleterious	0.02	0.35	0.81	disease	0.88	disease	0.6	disease	0.64	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.42	medium_impact	3.12	high_impact	0.35	0.8	55.53	8.57	0.62	P	0.98	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15140	15140	G	C	MI.9169	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	394	132	V	L	Gtc/Ctc	-5.78	0	0.01	probably_damaging	0.99	neutral	0.6	neutral	3	neutral	-1.22	deleterious	-2.51	high_impact	4.16	0.92	neutral	0.41	neutral	1.76	14.75	neutral	0.12	0.4	0.45	neutral	0.72	disease	0.56	disease	0.63	disease	3	0.99	deleterious	0.31	neutral	2	deleterious	0.77	deleterious	-2.59	low_impact	0.32	medium_impact	2.58	high_impact	0.42	0.8	55.53	8.57	0.29	N	0.69	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8957	8957	T	G	MI.917	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	431	144	I	S	aTc/aGc	8.69	1	0	probably_damaging	0.99	deleterious	0.02	neutral	3.83	deleterious	-6.41	deleterious	-5.49	high_impact	4.52	0.85	neutral	0.18	damaging	4.25	23.90	deleterious	0.2	0.65	0.96	disease	0.78	disease	0.69	disease	0.81	disease	6	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-2.65	low_impact	-0.66	medium_impact	2.78	high_impact	0.52	0.9	49.12	8.59	0.53	P	0.98	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15141	15141	T	A	MI.9170	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	395	132	V	D	gTc/gAc	5.92	1	0	probably_damaging	1	neutral	0.16	neutral	2.86	deleterious	-4.91	deleterious	-6	high_impact	5.09	0.86	neutral	0.4	neutral	4.35	24.10	deleterious	0.01	0.35	0.94	disease	0.85	disease	0.75	disease	0.65	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.17	medium_impact	3.43	high_impact	0.20	0.8	55.53	8.57	0.7	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15141	15141	T	C	MI.9171	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	395	132	V	A	gTc/gCc	5.92	1	0	probably_damaging	1	neutral	0.47	neutral	2.92	neutral	-2.3	deleterious	-3.41	high_impact	5.44	0.92	neutral	0.5	neutral	3.31	22.90	deleterious	0.05	0.35	0.71	disease	0.64	disease	0.65	disease	0.65	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.19	medium_impact	3.75	high_impact	0.20	0.8	55.53	8.57	0.75	P	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15141	15141	T	G	MI.9172	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	395	132	V	G	gTc/gGc	5.92	1	0	probably_damaging	1	neutral	0.42	neutral	2.87	deleterious	-4.01	deleterious	-6.02	high_impact	5.09	0.91	neutral	0.47	neutral	3.72	23.30	deleterious	0.02	0.35	0.9	disease	0.75	disease	0.68	disease	0.64	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.15	medium_impact	3.43	high_impact	0.29	0.8	55.53	8.57	0.71	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15143	15143	C	A	MI.9173	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	397	133	L	I	Ctc/Atc	-8.76	0	0	probably_damaging	1	neutral	0.37	neutral	1.27	deleterious	-5.76	neutral	-1.73	high_impact	4.96	0.87	neutral	0.06	damaging	3.92	23.50	deleterious	0.19	0.45	0.59	disease	0.76	disease	0.72	disease	0.67	disease	3	1	deleterious	0.19	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.1	medium_impact	3.31	high_impact	0.57	0.8	56.84	8.46	0.67	P	0.86	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15143	15143	C	T	MI.9174	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	397	133	L	F	Ctc/Ttc	-8.76	0	0	probably_damaging	1	neutral	0.75	neutral	1.24	deleterious	-6.83	deleterious	-3.46	high_impact	4.7	0.91	neutral	0.05	damaging	3.85	23.40	deleterious	0.11	0.4	0.75	disease	0.75	disease	0.68	disease	0.66	disease	3	1	deleterious	0.38	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.48	medium_impact	3.07	high_impact	0.63	0.8	56.84	8.46	0.48	N	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15143	15143	C	G	MI.9175	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	397	133	L	V	Ctc/Gtc	-8.76	0	0	probably_damaging	0.99	neutral	0.76	neutral	1.25	deleterious	-6.35	deleterious	-2.6	high_impact	5.16	0.81	neutral	0.08	damaging	3.09	22.50	deleterious	0.14	0.4	0.58	disease	0.68	disease	0.73	disease	0.68	disease	4	0.99	deleterious	0.39	neutral	2	deleterious	0.77	deleterious	-2.59	low_impact	0.49	medium_impact	3.49	high_impact	0.50	0.8	56.84	8.46	0.6	P	0.91	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15144	15144	T	C	MI.9176	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	398	133	L	P	cTc/cCc	1.33	0.72	0	probably_damaging	1	neutral	0.28	neutral	1.2	deleterious	-10.13	deleterious	-6.06	high_impact	4.7	0.86	neutral	0.03	damaging	3.83	23.40	deleterious	0.02	0.35	0.76	disease	0.8	disease	0.7	disease	0.68	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0	medium_impact	3.07	high_impact	0.28	0.8	56.84	8.46	0.49	N	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15144	15144	T	G	MI.9177	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	398	133	L	R	cTc/cGc	1.33	0.72	0	probably_damaging	1	neutral	0.31	neutral	1.2	deleterious	-9.79	deleterious	-5.2	high_impact	5.51	0.83	neutral	0.03	damaging	4.10	23.70	deleterious	0.01	0.35	0.86	disease	0.9	disease	0.81	disease	0.7	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.03	medium_impact	3.81	high_impact	0.27	0.8	56.84	8.46	0.67	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15144	15144	T	A	MI.9178	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	398	133	L	H	cTc/cAc	1.33	0.72	0	probably_damaging	1	neutral	0.48	neutral	1.2	deleterious	-10.71	deleterious	-6.06	high_impact	5.51	0.88	neutral	0.06	damaging	4.07	23.70	deleterious	0.02	0.35	0.91	disease	0.8	disease	0.79	disease	0.69	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.2	medium_impact	3.81	high_impact	0.32	0.8	56.84	8.46	0.62	P	0.95	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15146	15146	C	G	MI.9179	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	400	134	P	A	Ccg/Gcg	-9.45	0	0	probably_damaging	1	neutral	0.56	neutral	2.87	deleterious	-4.32	deleterious	-6.89	high_impact	5.14	0.94	neutral	0.51	neutral	2.74	21.00	deleterious	0.13	0.4	0.56	disease	0.74	disease	0.72	disease	0.67	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.28	medium_impact	3.47	high_impact	0.63	0.8	58.95	8.8	0.58	P	0.84	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8957	8957	T	C	MI.918	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	431	144	I	T	aTc/aCc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	3.84	deleterious	-5.71	deleterious	-4.56	high_impact	3.97	0.93	neutral	0.17	damaging	3.43	23.00	deleterious	0.33	0.65	0.93	disease	0.66	disease	0.69	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.65	low_impact	-1.4	low_impact	2.3	high_impact	0.61	0.9	49.12	8.59	0.53	N	0.99	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15146	15146	C	T	MI.9180	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	400	134	P	S	Ccg/Tcg	-9.45	0	0	probably_damaging	1	neutral	0.42	neutral	2.87	deleterious	-4.81	deleterious	-6.89	high_impact	4.94	0.93	neutral	0.47	neutral	3.77	23.40	deleterious	0.12	0.4	0.65	disease	0.82	disease	0.7	disease	0.69	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.15	medium_impact	3.29	high_impact	0.16	0.8	58.95	8.8	0.64	P	0.90	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15146	15146	C	A	MI.9181	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	400	134	P	T	Ccg/Acg	-9.45	0	0	probably_damaging	1	neutral	0.39	neutral	2.85	deleterious	-4.98	deleterious	-6.89	high_impact	4.8	0.92	neutral	0.45	neutral	3.54	23.10	deleterious	0.11	0.4	0.7	disease	0.83	disease	0.65	disease	0.66	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.12	medium_impact	3.17	high_impact	0.54	0.8	58.95	8.8	0.62	P	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15147	15147	C	G	MI.9182	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	401	134	P	R	cCg/cGg	5.46	1	0	probably_damaging	1	neutral	0.34	neutral	2.85	deleterious	-5.36	deleterious	-7.76	high_impact	5.49	0.93	neutral	0.37	neutral	3.54	23.10	deleterious	0.05	0.35	0.85	disease	0.91	disease	0.81	disease	0.67	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.07	medium_impact	3.79	high_impact	0.35	0.8	58.95	8.8	0.7	P	0.80	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15147	15147	C	A	MI.9183	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	401	134	P	Q	cCg/cAg	5.46	1	0	probably_damaging	1	neutral	0.31	neutral	2.81	deleterious	-5.96	deleterious	-6.89	high_impact	5.49	0.93	neutral	0.39	neutral	4.04	23.70	deleterious	0.08	0.35	0.87	disease	0.85	disease	0.73	disease	0.63	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.03	medium_impact	3.79	high_impact	0.33	0.8	58.95	8.8	0.71	P	0.86	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15147	15147	C	T	MI.9184	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	401	134	P	L	cCg/cTg	5.46	1	0	probably_damaging	1	neutral	0.73	neutral	2.87	deleterious	-4.6	deleterious	-8.62	high_impact	4.68	0.91	neutral	0.38	neutral	4.32	24.00	deleterious	0.06	0.35	0.73	disease	0.87	disease	0.68	disease	0.68	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.46	medium_impact	3.06	high_impact	0.57	0.8	58.95	8.8	0.62	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15149	15149	T	G	MI.9185	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	403	135	W	G	Tga/Gga	-0.96	0.02	0	probably_damaging	1	neutral	0.39	neutral	3.13	neutral	-2.37	deleterious	-10.53	high_impact	4.96	0.8	neutral	0.13	damaging	3.81	23.40	deleterious	0.05	0.35	0.91	disease	0.85	disease	0.82	disease	0.63	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.12	medium_impact	3.31	high_impact	0.14	0.8	56.32	8.6	0.68	P	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15149	15149	T	C	MI.9186	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	403	135	W	R	Tga/Cga	-0.96	0.02	0	probably_damaging	1	neutral	0.33	neutral	3.01	deleterious	-3.75	deleterious	-11.34	high_impact	5.16	0.82	neutral	0.07	damaging	3.46	23.00	deleterious	0.05	0.35	0.9	disease	0.93	disease	0.84	disease	0.63	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.06	medium_impact	3.49	high_impact	0.15	0.8	56.32	8.6	0.65	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15150	15150	G	C	MI.9187	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	404	135	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.42	neutral	3.06	neutral	-2.72	deleterious	-11.34	high_impact	4.61	0.79	neutral	0.1	damaging	3.90	23.50	deleterious	0.05	0.35	0.85	disease	0.91	disease	0.81	disease	0.66	disease	3	1	deleterious	0.21	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.15	medium_impact	2.99	high_impact	0.12	0.8	56.32	8.6	0.6	P	0.99	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15150	15150	G	T	MI.9188	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	404	135	W	L	tGa/tTa	7.3	1	0	probably_damaging	1	neutral	0.69	neutral	3.09	neutral	-2.37	deleterious	-10.53	high_impact	4.96	0.8	neutral	0.08	damaging	4.20	23.90	deleterious	0.06	0.35	0.69	disease	0.86	disease	0.81	disease	0.71	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.41	medium_impact	3.31	high_impact	0.08	0.8	56.32	8.6	0.71	P	0.99	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15151	15151	A	C	MI.9189	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	405	135	W	C	tgA/tgC	8.9	1	0	probably_damaging	1	neutral	0.17	neutral	3.02	deleterious	-5.17	deleterious	-10.53	high_impact	5.5	0.83	neutral	0.05	damaging	3.94	23.50	deleterious	0.05	0.35	0.93	disease	0.92	disease	0.85	disease	0.66	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.15	medium_impact	3.8	high_impact	0.19	0.8	56.32	8.6	0.65	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8958	8958	C	G	MI.919	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	432	144	I	M	atC/atG	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	3.92	deleterious	-4.95	deleterious	-2.76	high_impact	3.83	0.83	neutral	0.15	damaging	3.39	23.00	deleterious	0.32	0.65	0.76	disease	0.59	disease	0.71	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-3.6	low_impact	-0.84	medium_impact	2.19	high_impact	0.75	0.9	49.12	8.59	0.5	P	0.75	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15151	15151	A	T	MI.9190	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	405	135	W	C	tgA/tgT	8.9	1	0	probably_damaging	1	neutral	0.17	neutral	3.02	deleterious	-5.17	deleterious	-10.53	high_impact	5.5	0.83	neutral	0.05	damaging	4.06	23.70	deleterious	0.05	0.35	0.93	disease	0.92	disease	0.85	disease	0.66	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.15	medium_impact	3.8	high_impact	0.19	0.8	56.32	8.6	0.65	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15152	15152	G	T	MI.9191	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	406	136	G	C	Ggc/Tgc	2.48	1	0	probably_damaging	1	neutral	0.17	neutral	3.03	deleterious	-6.3	deleterious	-7.32	high_impact	5.5	0.91	neutral	0.23	damaging	4.18	23.80	deleterious	0.03	0.35	0.9	disease	0.93	disease	0.73	disease	0.64	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.15	medium_impact	3.8	high_impact	0.16	0.8	58.68	8.75	0.65	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15152	15152	G	A	MI.9192	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	406	136	G	S	Ggc/Agc	2.48	1	0	probably_damaging	1	neutral	0.44	neutral	3.09	neutral	-1.93	deleterious	-4.87	high_impact	4.12	0.9	neutral	0.34	neutral	4.12	23.80	deleterious	0.05	0.35	0.66	disease	0.86	disease	0.72	disease	0.69	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.17	medium_impact	2.55	high_impact	0.32	0.8	58.68	8.75	0.55	P	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15152	15152	G	C	MI.9193	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	406	136	G	R	Ggc/Cgc	2.48	1	0	probably_damaging	1	neutral	0.34	neutral	3.07	deleterious	-3.05	deleterious	-6.5	high_impact	5.5	0.9	neutral	0.24	damaging	3.94	23.60	deleterious	0.05	0.35	0.88	disease	0.93	disease	0.82	disease	0.65	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.07	medium_impact	3.8	high_impact	0.28	0.8	58.68	8.75	0.7	P	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15153	15153	G	A	MI.9194	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	407	136	G	D	gGc/gAc	7.07	1	0	probably_damaging	1	neutral	0.2	neutral	3.61	neutral	1.06	deleterious	-5.69	high_impact	5.5	0.78	neutral	0.3	neutral	3.86	23.50	deleterious	0.05	0.35	0.8	disease	0.9	disease	0.8	disease	0.69	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.1	medium_impact	3.8	high_impact	0.15	0.8	58.68	8.75	0.72	P	1.00	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15153	15153	G	C	MI.9195	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	407	136	G	A	gGc/gCc	7.07	1	0	probably_damaging	1	neutral	0.53	neutral	3.1	neutral	-2.58	deleterious	-4.87	high_impact	4.4	0.91	neutral	0.43	neutral	3.05	22.40	deleterious	0.06	0.35	0.49	neutral	0.82	disease	0.63	disease	0.65	disease	3	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.25	medium_impact	2.8	high_impact	0.33	0.8	58.68	8.75	0.54	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15153	15153	G	T	MI.9196	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	407	136	G	V	gGc/gTc	7.07	1	0	probably_damaging	1	neutral	0.58	neutral	3.05	deleterious	-3.95	deleterious	-7.31	high_impact	5.5	0.91	neutral	0.37	neutral	3.73	23.30	deleterious	0.04	0.35	0.83	disease	0.92	disease	0.74	disease	0.66	disease	3	1	deleterious	0.29	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.3	medium_impact	3.8	high_impact	0.10	0.8	58.68	8.75	0.69	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15155	15155	C	G	MI.9197	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	409	137	Q	E	Caa/Gaa	-4.4	0	0	probably_damaging	0.99	neutral	0.27	neutral	3.01	neutral	-2.17	neutral	-2.43	high_impact	5.17	0.92	neutral	0.4	neutral	1.35	12.52	neutral	0.19	0.45	0.75	disease	0.84	disease	0.81	disease	0.68	disease	4	0.99	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-2.59	low_impact	-0.01	medium_impact	3.5	high_impact	0.28	0.8	57.89	8.75	0.76	P	0.93	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15155	15155	C	A	MI.9198	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	409	137	Q	K	Caa/Aaa	-4.4	0	0	probably_damaging	1	neutral	0.29	neutral	3.01	neutral	-2.57	deleterious	-3.24	high_impact	5.17	0.93	neutral	0.34	neutral	3.74	23.30	deleterious	0.15	0.4	0.72	disease	0.9	disease	0.81	disease	0.72	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.01	medium_impact	3.5	high_impact	0.31	0.8	57.89	8.75	0.79	P	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15156	15156	A	C	MI.9199	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	410	137	Q	P	cAa/cCa	7.07	1	0	probably_damaging	1	neutral	0.21	neutral	2.93	deleterious	-4.68	deleterious	-4.87	high_impact	4.2	0.91	neutral	0.28	damaging	3.14	22.60	deleterious	0.07	0.35	0.9	disease	0.91	disease	0.84	disease	0.63	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.09	medium_impact	2.62	high_impact	0.24	0.8	57.89	8.75	0.63	P	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8567	8567	T	G	MI.92	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	41	14	I	S	aTc/aGc	-4.27	0	0	possibly_damaging	0.68	neutral	0.65	neutral	4.61	neutral	-0.78	deleterious	-3.12	neutral_impact	0.17	0.84	neutral	0.5	neutral	3.68	23.30	deleterious	0.42	0.65	0.46	neutral	0.5	neutral	0.62	disease	0.49	neutral	0	0.62	neutral	0.49	deleterious	-3	neutral	0.47	deleterious	-1.07	low_impact	0.44	medium_impact	-0.95	medium_impact	0.65	0.9	13.72	12.42	0.22	N	0.50	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8958	8958	C	A	MI.920	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	432	144	I	M	atC/atA	7.53	1	0	probably_damaging	1	deleterious	0.01	neutral	3.92	deleterious	-4.95	deleterious	-2.76	high_impact	3.83	0.83	neutral	0.15	damaging	3.85	23.40	deleterious	0.32	0.65	0.76	disease	0.59	disease	0.71	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.77	deleterious	-3.6	low_impact	-0.84	medium_impact	2.19	high_impact	0.75	0.9	49.12	8.59	0.51	N	0.75	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15156	15156	A	G	MI.9200	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	410	137	Q	R	cAa/cGa	7.07	1	0	probably_damaging	1	neutral	0.35	neutral	2.96	deleterious	-3.29	deleterious	-3.24	high_impact	5.51	0.93	neutral	0.37	neutral	3.38	22.90	deleterious	0.18	0.45	0.76	disease	0.92	disease	0.77	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.08	medium_impact	3.81	high_impact	0.14	0.8	57.89	8.75	0.79	P	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15156	15156	A	T	MI.9201	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	410	137	Q	L	cAa/cTa	7.07	1	0	probably_damaging	1	neutral	0.66	neutral	3.11	neutral	-2.06	deleterious	-5.68	high_impact	5.17	0.93	neutral	0.36	neutral	3.69	23.30	deleterious	0.08	0.35	0.86	disease	0.92	disease	0.73	disease	0.63	disease	3	1	deleterious	0.33	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.38	medium_impact	3.5	high_impact	0.22	0.8	57.89	8.75	0.75	P	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15157	15157	A	C	MI.9202	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	411	137	Q	H	caA/caC	8.44	1	0	probably_damaging	1	neutral	0.54	neutral	2.96	deleterious	-4.34	deleterious	-4.05	high_impact	5.51	0.92	neutral	0.3	neutral	3.11	22.50	deleterious	0.12	0.4	0.9	disease	0.87	disease	0.73	disease	0.61	disease	2	1	deleterious	0.27	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.26	medium_impact	3.81	high_impact	0.33	0.8	57.89	8.75	0.77	P	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15157	15157	A	T	MI.9203	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	411	137	Q	H	caA/caT	8.44	1	0	probably_damaging	1	neutral	0.54	neutral	2.96	deleterious	-4.34	deleterious	-4.05	high_impact	5.51	0.92	neutral	0.3	neutral	3.28	22.80	deleterious	0.12	0.4	0.9	disease	0.87	disease	0.73	disease	0.61	disease	2	1	deleterious	0.27	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.26	medium_impact	3.81	high_impact	0.33	0.8	57.89	8.75	0.78	P	0.97	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15158	15158	A	C	MI.9204	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	412	138	M	L	Ata/Cta	2.48	1	0	probably_damaging	0.96	neutral	0.65	neutral	3.47	neutral	0.76	neutral	-2.42	high_impact	4.63	0.94	neutral	0.08	damaging	1.24	11.97	neutral	0.26	0.45	0.34	neutral	0.84	disease	0.74	disease	0.7	disease	4	0.96	neutral	0.35	neutral	2	deleterious	0.76	deleterious	-2.02	low_impact	0.37	medium_impact	3.01	high_impact	0.19	0.8	56.84	8.61	0.49	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15158	15158	A	T	MI.9205	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	412	138	M	L	Ata/Tta	2.48	1	0	probably_damaging	0.96	neutral	0.65	neutral	3.47	neutral	0.76	neutral	-2.42	high_impact	4.63	0.94	neutral	0.08	damaging	1.34	12.50	neutral	0.26	0.45	0.34	neutral	0.84	disease	0.74	disease	0.7	disease	4	0.96	neutral	0.35	neutral	2	deleterious	0.76	deleterious	-2.02	low_impact	0.37	medium_impact	3.01	high_impact	0.19	0.8	56.84	8.61	0.49	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15158	15158	A	G	MI.9206	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	412	138	M	V	Ata/Gta	2.48	1	0	probably_damaging	0.98	neutral	0.51	neutral	3.11	neutral	-1.41	deleterious	-3.23	high_impact	4.83	0.94	neutral	0.1	damaging	0.78	9.31	deleterious	0.27	0.45	0.59	disease	0.87	disease	0.77	disease	0.71	disease	4	0.97	neutral	0.27	neutral	2	deleterious	0.83	deleterious	-2.31	low_impact	0.23	medium_impact	3.19	high_impact	0.20	0.8	56.84	8.61	0.71	P	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15159	15159	T	C	MI.9207	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	413	138	M	T	aTa/aCa	6.84	1	0	probably_damaging	1	neutral	0.4	neutral	3.06	neutral	-2.24	deleterious	-4.84	high_impact	5.18	0.93	neutral	0.11	damaging	2.67	20.60	deleterious	0.09	0.35	0.82	disease	0.89	disease	0.76	disease	0.68	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.13	medium_impact	3.51	high_impact	0.12	0.8	56.84	8.61	0.76	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	COSM6188314	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15159	15159	T	A	MI.9208	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	413	138	M	K	aTa/aAa	6.84	1	0	probably_damaging	0.99	neutral	0.29	neutral	3.05	neutral	-2.41	deleterious	-4.85	high_impact	5.18	0.93	neutral	0.08	damaging	2.47	19.25	deleterious	0.07	0.35	0.88	disease	0.91	disease	0.82	disease	0.64	disease	3	0.99	deleterious	0.15	neutral	2	deleterious	0.89	deleterious	-2.59	low_impact	0.01	medium_impact	3.51	high_impact	0.08	0.8	56.84	8.61	0.8	P	0.99	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15160	15160	A	C	MI.9209	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	414	138	M	I	atA/atC	4.54	1	0	probably_damaging	0.98	neutral	0.4	neutral	3.11	neutral	-1.31	deleterious	-3.23	high_impact	4.55	0.93	neutral	0.09	damaging	1.61	13.92	neutral	0.21	0.45	0.56	disease	0.89	disease	0.73	disease	0.71	disease	4	0.98	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-2.31	low_impact	0.13	medium_impact	2.94	high_impact	0.23	0.8	56.84	8.61	0.56	P	0.95	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8959	8959	G	C	MI.921	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	433	145	E	Q	Gaa/Caa	-5.66	0	0	probably_damaging	0.99	deleterious	0	neutral	3.72	deleterious	-5.44	deleterious	-2.75	high_impact	4.63	0.65	neutral	0.59	neutral	3.33	22.90	deleterious	0.37	0.65	0.87	disease	0.57	disease	0.77	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.83	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.67	0.9	49.12	8.84	0.56	P	0.91	disease_causing	0.91	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15160	15160	A	T	MI.9210	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	414	138	M	I	atA/atT	4.54	1	0	probably_damaging	0.98	neutral	0.4	neutral	3.11	neutral	-1.31	deleterious	-3.23	high_impact	4.55	0.93	neutral	0.09	damaging	1.69	14.35	neutral	0.21	0.45	0.56	disease	0.89	disease	0.73	disease	0.71	disease	4	0.98	deleterious	0.21	neutral	2	deleterious	0.85	deleterious	-2.31	low_impact	0.13	medium_impact	2.94	high_impact	0.23	0.8	56.84	8.61	0.59	P	0.95	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15161	15161	T	C	MI.9211	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	415	139	S	P	Tca/Cca	4.54	1	0	probably_damaging	1	neutral	0.21	neutral	2.66	deleterious	-6.49	deleterious	-4.05	high_impact	5	0.88	neutral	0.04	damaging	3.81	23.40	deleterious	0.06	0.35	0.88	disease	0.86	disease	0.84	disease	0.65	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.09	medium_impact	3.35	high_impact	0.20	0.8	58.68	8.67	0.76	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15161	15161	T	G	MI.9212	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	415	139	S	A	Tca/Gca	4.54	1	0	probably_damaging	0.99	neutral	0.51	neutral	2.99	neutral	-1.45	neutral	-2.42	high_impact	5.2	0.88	neutral	0.14	damaging	3.28	22.80	deleterious	0.19	0.45	0.61	disease	0.74	disease	0.74	disease	0.69	disease	4	0.99	deleterious	0.26	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.23	medium_impact	3.53	high_impact	0.33	0.8	58.68	8.67	0.71	P	0.46	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15161	15161	T	A	MI.9213	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	415	139	S	T	Tca/Aca	4.54	1	0	probably_damaging	0.99	neutral	0.4	neutral	2.69	deleterious	-4.82	neutral	-2.42	high_impact	5.54	0.86	neutral	0.1	damaging	2.04	16.49	deleterious	0.17	0.45	0.75	disease	0.78	disease	0.75	disease	0.69	disease	4	0.99	deleterious	0.21	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.13	medium_impact	3.84	high_impact	0.44	0.8	58.68	8.67	0.74	P	0.70	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15162	15162	C	G	MI.9214	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	416	139	S	W	tCa/tGa	5.69	1	0	probably_damaging	1	neutral	0.19	neutral	2.64	deleterious	-9.97	deleterious	-5.66	high_impact	5.54	0.89	neutral	0.09	damaging	4.27	23.90	deleterious	0.05	0.35	0.98	disease	0.91	disease	0.79	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.12	medium_impact	3.84	high_impact	0.14	0.8	58.68	8.67	0.66	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15162	15162	C	T	MI.9215	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	416	139	S	L	tCa/tTa	5.69	1	0	probably_damaging	1	neutral	0.65	neutral	2.68	deleterious	-6.85	deleterious	-4.85	high_impact	5	0.88	neutral	0.06	damaging	4.57	24.40	deleterious	0.04	0.35	0.9	disease	0.89	disease	0.73	disease	0.62	disease	2	1	deleterious	0.33	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.37	medium_impact	3.35	high_impact	0.50	0.8	58.68	8.67	0.77	P	1.00	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15164	15164	T	A	MI.9216	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	418	140	F	I	Ttc/Atc	-10.6	0	0	benign	0.36	neutral	0.4	neutral	3.14	neutral	-1.02	deleterious	-4.86	high_impact	5.11	0.94	neutral	0.48	neutral	4.25	23.90	deleterious	0.12	0.4	0.81	disease	0.86	disease	0.72	disease	0.65	disease	3	0.53	neutral	0.52	deleterious	-2	neutral	0.62	deleterious	-0.5	medium_impact	0.13	medium_impact	3.45	high_impact	0.41	0.8	55.79	8.33	0.64	P	0.97	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15164	15164	T	C	MI.9217	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	418	140	F	L	Ttc/Ctc	-10.6	0	0	benign	0.02	neutral	0.66	neutral	3.11	neutral	-0.48	deleterious	-4.85	medium_impact	3.42	0.94	neutral	0.61	neutral	3.74	23.30	deleterious	0.15	0.4	0.46	neutral	0.81	disease	0.61	disease	0.52	disease	0	0.3	neutral	0.82	deleterious	-3	neutral	0.24	neutral	0.85	medium_impact	0.38	medium_impact	1.91	medium_impact	0.48	0.8	55.79	8.33	0.29	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15164	15164	T	G	MI.9218	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	418	140	F	V	Ttc/Gtc	-10.6	0	0	possibly_damaging	0.68	neutral	0.51	neutral	3.17	neutral	-0.31	deleterious	-5.67	high_impact	5.11	0.94	neutral	0.5	neutral	4.03	23.60	deleterious	0.08	0.35	0.8	disease	0.88	disease	0.76	disease	0.67	disease	3	0.66	neutral	0.42	neutral	1	deleterious	0.66	deleterious	-1.04	low_impact	0.23	medium_impact	3.45	high_impact	0.32	0.8	55.79	8.33	0.68	P	0.99	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15165	15165	T	A	MI.9219	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	419	140	F	Y	tTc/tAc	5.69	1	0	possibly_damaging	0.72	neutral	1	neutral	3.14	neutral	0.67	neutral	-2.43	medium_impact	2.79	0.94	neutral	0.45	neutral	4.09	23.70	deleterious	0.1	0.4	0.3	neutral	0.82	disease	0.69	disease	0.67	disease	3	0.72	neutral	0.64	deleterious	0	NA	0.67	deleterious	-1.11	low_impact	1.85	high_impact	1.34	medium_impact	0.54	0.8	55.79	8.33	0.49	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8959	8959	G	A	MI.922	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	433	145	E	K	Gaa/Aaa	-5.66	0	0	probably_damaging	0.99	deleterious	0	neutral	3.88	deleterious	-5.32	deleterious	-3.67	high_impact	4.29	0.58	damaging	0.46	neutral	4.53	24.30	deleterious	0.33	0.65	0.75	disease	0.78	disease	0.84	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.87	deleterious	-2.65	low_impact	-1.4	low_impact	2.58	high_impact	0.71	0.9	49.12	8.84	0.46	N	1.00	disease_causing	0.98	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15165	15165	T	G	MI.9220	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	419	140	F	C	tTc/tGc	5.69	1	0	probably_damaging	0.99	neutral	0.18	neutral	3.03	deleterious	-3.59	deleterious	-6.49	high_impact	5.46	0.93	neutral	0.4	neutral	4.00	23.60	deleterious	0.04	0.35	0.94	disease	0.89	disease	0.75	disease	0.62	disease	2	0.99	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	-0.14	medium_impact	3.76	high_impact	0.26	0.8	55.79	8.33	0.73	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15165	15165	T	C	MI.9221	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	419	140	F	S	tTc/tCc	5.69	1	0	probably_damaging	0.99	neutral	0.42	neutral	3.07	neutral	-2.11	deleterious	-6.48	high_impact	4.76	0.93	neutral	0.44	neutral	4.22	23.90	deleterious	0.03	0.35	0.86	disease	0.87	disease	0.74	disease	0.63	disease	3	0.99	deleterious	0.22	neutral	2	deleterious	0.85	deleterious	-2.59	low_impact	0.15	medium_impact	3.13	high_impact	0.17	0.8	55.79	8.33	0.77	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15166	15166	C	A	MI.9222	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	420	140	F	L	ttC/ttA	5.69	1	0	benign	0.02	neutral	0.66	neutral	3.11	neutral	-0.48	deleterious	-4.85	medium_impact	3.42	0.94	neutral	0.61	neutral	4.28	24.00	deleterious	0.15	0.4	0.46	neutral	0.81	disease	0.61	disease	0.52	disease	0	0.3	neutral	0.82	deleterious	-3	neutral	0.24	neutral	0.85	medium_impact	0.38	medium_impact	1.91	medium_impact	0.48	0.8	55.79	8.33	0.52	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15166	15166	C	G	MI.9223	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	420	140	F	L	ttC/ttG	5.69	1	0	benign	0.02	neutral	0.66	neutral	3.11	neutral	-0.48	deleterious	-4.85	medium_impact	3.42	0.94	neutral	0.61	neutral	4.04	23.70	deleterious	0.15	0.4	0.46	neutral	0.81	disease	0.61	disease	0.52	disease	0	0.3	neutral	0.82	deleterious	-3	neutral	0.24	neutral	0.85	medium_impact	0.38	medium_impact	1.91	medium_impact	0.48	0.8	55.79	8.33	0.52	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15167	15167	T	G	MI.9224	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	421	141	W	G	Tga/Gga	-0.96	0.01	0	probably_damaging	1	neutral	0.48	neutral	3	deleterious	-4.13	deleterious	-10.48	high_impact	4.78	0.8	neutral	0.13	damaging	3.73	23.30	deleterious	0.03	0.35	0.94	disease	0.86	disease	0.82	disease	0.63	disease	3	1	deleterious	0.24	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.2	medium_impact	3.15	high_impact	0.19	0.8	58.68	8.66	0.69	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15167	15167	T	C	MI.9225	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	421	141	W	R	Tga/Cga	-0.96	0.01	0	probably_damaging	1	neutral	0.35	neutral	3.01	deleterious	-3.46	deleterious	-11.29	high_impact	5.04	0.83	neutral	0.07	damaging	3.47	23.00	deleterious	0.02	0.35	0.96	disease	0.93	disease	0.86	disease	0.65	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.08	medium_impact	3.38	high_impact	0.22	0.8	58.68	8.66	0.66	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15168	15168	G	T	MI.9226	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	422	141	W	L	tGa/tTa	7.3	1	0	probably_damaging	1	neutral	0.75	neutral	3.11	neutral	-2.64	deleterious	-10.48	high_impact	5.04	0.8	neutral	0.08	damaging	4.11	23.70	deleterious	0.04	0.35	0.93	disease	0.88	disease	0.8	disease	0.61	disease	2	1	deleterious	0.38	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.48	medium_impact	3.38	high_impact	0.13	0.8	58.68	8.66	0.7	P	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15168	15168	G	C	MI.9227	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	422	141	W	S	tGa/tCa	7.3	1	0	probably_damaging	1	neutral	0.55	neutral	3.09	neutral	-2.58	deleterious	-11.28	high_impact	4.54	0.79	neutral	0.1	damaging	3.89	23.50	deleterious	0.03	0.35	0.96	disease	0.92	disease	0.81	disease	0.61	disease	2	1	deleterious	0.28	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.27	medium_impact	2.93	high_impact	0.12	0.8	58.68	8.66	0.55	P	0.99	disease_causing	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15169	15169	A	T	MI.9228	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	423	141	W	C	tgA/tgT	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	2.98	deleterious	-5.42	deleterious	-10.49	high_impact	4.68	0.83	neutral	0.05	damaging	4.05	23.70	deleterious	0.03	0.35	0.98	disease	0.93	disease	0.85	disease	0.7	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.14	medium_impact	3.06	high_impact	0.19	0.8	58.68	8.66	0.62	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15169	15169	A	C	MI.9229	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	423	141	W	C	tgA/tgC	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	2.98	deleterious	-5.42	deleterious	-10.49	high_impact	4.68	0.83	neutral	0.05	damaging	3.94	23.50	deleterious	0.03	0.35	0.98	disease	0.93	disease	0.85	disease	0.7	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.14	medium_impact	3.06	high_impact	0.19	0.8	58.68	8.66	0.61	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8960	8960	A	G	MI.923	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	434	145	E	G	gAa/gGa	3.6	1	0	probably_damaging	0.99	deleterious	0	neutral	3.69	deleterious	-6.42	deleterious	-6.43	high_impact	4.63	0.56	damaging	0.63	neutral	4.31	24.00	deleterious	0.3	0.65	0.92	disease	0.6	disease	0.76	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.40	0.9	49.12	8.84	0.52	P	0.71	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15170	15170	G	C	MI.9230	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	424	142	G	R	Ggg/Cgg	3.17	1	0	probably_damaging	1	neutral	0.34	neutral	2.77	deleterious	-3.59	deleterious	-6.43	high_impact	5.53	0.95	neutral	0.25	damaging	3.92	23.50	deleterious	0.02	0.35	0.9	disease	0.91	disease	0.78	disease	0.65	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.07	medium_impact	3.83	high_impact	0.72	0.85	58.16	8.65	0.71	P	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15170	15170	G	T	MI.9231	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	424	142	G	W	Ggg/Tgg	3.17	1	0	probably_damaging	1	neutral	0.39	neutral	2.75	deleterious	-8.01	deleterious	-6.45	high_impact	5.17	0.89	neutral	0.24	damaging	4.44	24.20	deleterious	0.03	0.35	0.98	disease	0.92	disease	0.73	disease	0.66	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.12	medium_impact	3.5	high_impact	0.16	0.8	58.16	8.65	0.64	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15171	15171	G	A	MI.9232	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	425	142	G	E	gGg/gAg	7.3	1	0	probably_damaging	1	neutral	0.29	neutral	2.79	deleterious	-4.39	deleterious	-6.43	high_impact	5.17	0.86	neutral	0.3	neutral	3.85	23.40	deleterious	0.02	0.35	0.88	disease	0.9	disease	0.76	disease	0.62	disease	2	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.01	medium_impact	3.5	high_impact	0.22	0.8	58.16	8.65	0.74	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	COSM6716240	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15171	15171	G	C	MI.9233	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	425	142	G	A	gGg/gCg	7.3	1	0	probably_damaging	1	neutral	0.6	neutral	3.19	neutral	0.61	deleterious	-4.81	medium_impact	2.63	0.91	neutral	0.41	neutral	2.99	22.20	deleterious	0.05	0.35	0.44	neutral	0.77	disease	0.5	neutral	0.41	neutral	2	1	deleterious	0.3	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.32	medium_impact	1.19	medium_impact	0.56	0.8	58.16	8.65	0.46	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15171	15171	G	T	MI.9234	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	425	142	G	V	gGg/gTg	7.3	1	0	probably_damaging	1	neutral	0.53	neutral	2.82	deleterious	-4.33	deleterious	-7.23	high_impact	5.53	0.91	neutral	0.35	neutral	3.69	23.30	deleterious	0.02	0.35	0.76	disease	0.89	disease	0.69	disease	0.69	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.25	medium_impact	3.83	high_impact	0.17	0.8	58.16	8.65	0.67	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15173	15173	G	A	MI.9235	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	427	143	A	T	Gcc/Acc	-12.2	0	0	probably_damaging	1	neutral	0.75	neutral	3.07	neutral	-0.85	deleterious	-3.15	high_impact	4.54	0.92	neutral	0.12	damaging	4.07	23.70	deleterious	0.06	0.35	0.68	disease	0.79	disease	0.65	disease	0.67	disease	3	1	deleterious	0.38	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.48	medium_impact	2.93	high_impact	0.64	0.8	59.21	8.78	0.35	N	0.79	polymorphism	1	0.04	rs878866549	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15173	15173	G	C	MI.9236	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	427	143	A	P	Gcc/Ccc	-12.2	0	0	probably_damaging	1	neutral	0.19	neutral	2.95	deleterious	-4.07	deleterious	-3.97	high_impact	4.88	0.88	neutral	0.04	damaging	3.79	23.40	deleterious	0.03	0.35	0.84	disease	0.84	disease	0.77	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.12	medium_impact	3.24	high_impact	0.49	0.8	59.21	8.78	0.71	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15173	15173	G	T	MI.9237	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	427	143	A	S	Gcc/Tcc	-12.2	0	0	probably_damaging	1	neutral	0.77	neutral	2.98	neutral	-2.51	neutral	-2.37	high_impact	4.88	0.87	neutral	0.09	damaging	3.58	23.20	deleterious	0.09	0.35	0.64	disease	0.78	disease	0.6	disease	0.66	disease	3	1	deleterious	0.39	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.51	medium_impact	3.24	high_impact	0.56	0.8	59.21	8.78	0.58	P	0.91	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15174	15174	C	A	MI.9238	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	428	143	A	D	gCc/gAc	9.13	1	0	probably_damaging	1	neutral	0.13	neutral	2.94	deleterious	-4.41	deleterious	-4.75	high_impact	5.58	0.85	neutral	0.08	damaging	4.39	24.10	deleterious	0.02	0.35	0.8	disease	0.87	disease	0.76	disease	0.71	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.23	medium_impact	3.87	high_impact	0.26	0.8	59.21	8.78	0.73	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15174	15174	C	T	MI.9239	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	428	143	A	V	gCc/gTc	9.13	1	0	probably_damaging	1	neutral	0.5	neutral	3.16	neutral	-0.28	deleterious	-3.17	high_impact	4.88	0.88	neutral	0.11	damaging	4.32	24.00	deleterious	0.05	0.35	0.71	disease	0.79	disease	0.66	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.22	medium_impact	3.24	high_impact	0.75	0.85	59.21	8.78	0.71	P	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8960	8960	A	C	MI.924	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	434	145	E	A	gAa/gCa	3.6	1	0	probably_damaging	0.99	deleterious	0	neutral	3.71	deleterious	-5.75	deleterious	-5.48	high_impact	4.63	0.58	damaging	0.56	neutral	3.76	23.30	deleterious	0.21	0.65	0.88	disease	0.56	disease	0.75	disease	0.74	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.55	0.9	49.12	8.84	0.52	P	0.80	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15174	15174	C	G	MI.9240	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	428	143	A	G	gCc/gGc	9.13	1	0	probably_damaging	1	neutral	0.83	neutral	2.98	neutral	-2.52	deleterious	-3.17	high_impact	4.08	0.87	neutral	0.14	damaging	3.61	23.20	deleterious	0.09	0.35	0.74	disease	0.68	disease	0.64	disease	0.66	disease	3	1	deleterious	0.42	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.6	medium_impact	2.51	high_impact	0.69	0.85	59.21	8.78	0.51	N	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15176	15176	A	G	MI.9241	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	430	144	T	A	Aca/Gca	-9.22	0	0	probably_damaging	0.99	neutral	1	neutral	3.1	neutral	-1.51	deleterious	-3.92	high_impact	4.66	0.97	neutral	0.14	damaging	1.73	14.59	neutral	0.13	0.4	0.6	disease	0.74	disease	0.63	disease	0.65	disease	3	0.99	deleterious	0.51	deleterious	2	deleterious	0.76	deleterious	-2.59	low_impact	1.85	high_impact	3.04	high_impact	0.39	0.8	57.89	8.75	0.4	N	0.59	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15176	15176	A	T	MI.9242	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	430	144	T	S	Aca/Tca	-9.22	0	0	probably_damaging	0.99	neutral	0.59	neutral	3.1	neutral	-1.45	deleterious	-3.14	high_impact	4.06	0.93	neutral	0.1	damaging	1.73	14.59	neutral	0.25	0.45	0.7	disease	0.77	disease	0.58	disease	0.64	disease	3	0.99	deleterious	0.3	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.31	medium_impact	2.49	high_impact	0.56	0.8	57.89	8.75	0.23	N	0.81	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15176	15176	A	C	MI.9243	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	430	144	T	P	Aca/Cca	-9.22	0	0	probably_damaging	1	neutral	0.23	neutral	3.03	deleterious	-3.42	deleterious	-4.75	high_impact	4.87	0.95	neutral	0.06	damaging	3.31	22.90	deleterious	0.04	0.35	0.86	disease	0.87	disease	0.76	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.06	medium_impact	3.23	high_impact	0.35	0.8	57.89	8.75	0.72	P	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15177	15177	C	A	MI.9244	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	431	144	T	K	aCa/aAa	5.46	1	0	probably_damaging	1	neutral	0.26	neutral	3.12	neutral	-0.69	deleterious	-4.73	high_impact	5.56	0.94	neutral	0.08	damaging	4.15	23.80	deleterious	0.05	0.35	0.78	disease	0.89	disease	0.75	disease	0.7	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.02	medium_impact	3.86	high_impact	0.41	0.8	57.89	8.75	0.74	P	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15177	15177	C	T	MI.9245	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	431	144	T	M	aCa/aTa	5.46	1	0	probably_damaging	1	neutral	0.24	neutral	3.04	neutral	-2.79	deleterious	-4.73	high_impact	4.06	0.94	neutral	0.1	damaging	3.94	23.50	deleterious	0.06	0.35	0.5	neutral	0.85	disease	0.61	disease	0.68	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	-0.05	medium_impact	2.49	high_impact	0.49	0.8	57.89	8.75	0.48	N	0.96	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15179	15179	G	A	MI.9246	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	433	145	V	M	Gta/Ata	-6.24	0	0	probably_damaging	1	neutral	0.24	neutral	2.63	deleterious	-5.53	neutral	-2.37	high_impact	5.26	0.92	neutral	0.1	damaging	3.49	23.10	deleterious	0.09	0.35	0.86	disease	0.82	disease	0.7	disease	0.68	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.05	medium_impact	3.58	high_impact	0.77	0.85	58.42	8.67	0.69	P	0.97	polymorphism	1	0.27	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15179	15179	G	C	MI.9247	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	433	145	V	L	Gta/Cta	-6.24	0	0	probably_damaging	0.96	neutral	0.77	neutral	2.72	deleterious	-3.72	neutral	-2.37	high_impact	5.61	0.93	neutral	0.07	damaging	1.63	14.01	neutral	0.12	0.4	0.7	disease	0.79	disease	0.62	disease	0.65	disease	3	0.96	neutral	0.41	neutral	2	deleterious	0.79	deleterious	-2.02	low_impact	0.51	medium_impact	3.9	high_impact	0.50	0.8	58.42	8.67	0.61	P	0.69	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15179	15179	G	T	MI.9248	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	433	145	V	L	Gta/Tta	-6.24	0	0	probably_damaging	0.96	neutral	0.77	neutral	2.72	deleterious	-3.72	neutral	-2.37	high_impact	5.61	0.93	neutral	0.07	damaging	1.74	14.62	neutral	0.12	0.4	0.7	disease	0.79	disease	0.62	disease	0.65	disease	3	0.96	neutral	0.41	neutral	2	deleterious	0.79	deleterious	-2.02	low_impact	0.51	medium_impact	3.9	high_impact	0.50	0.8	58.42	8.67	0.61	P	0.69	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15180	15180	T	A	MI.9249	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	434	145	V	E	gTa/gAa	4.08	1	0	probably_damaging	1	neutral	0.26	neutral	2.62	deleterious	-6.96	deleterious	-4.75	high_impact	5.26	0.92	neutral	0.11	damaging	4.37	24.10	deleterious	0.02	0.35	0.85	disease	0.9	disease	0.79	disease	0.71	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.02	medium_impact	3.58	high_impact	0.28	0.8	58.42	8.67	0.78	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8960	8960	A	T	MI.925	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	434	145	E	V	gAa/gTa	3.6	1	0	probably_damaging	1	deleterious	0	neutral	3.68	deleterious	-7.45	deleterious	-6.43	high_impact	4.63	0.5	damaging	0.49	neutral	4.30	24.00	deleterious	0.2	0.65	0.94	disease	0.81	disease	0.78	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.58	0.9	49.12	8.84	0.53	P	0.86	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15180	15180	T	C	MI.9250	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	434	145	V	A	gTa/gCa	4.08	1	0	probably_damaging	1	neutral	0.61	neutral	2.71	deleterious	-4.08	deleterious	-3.15	high_impact	4.8	0.93	neutral	0.12	damaging	3.12	22.60	deleterious	0.05	0.35	0.69	disease	0.7	disease	0.66	disease	0.66	disease	3	1	deleterious	0.31	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.33	medium_impact	3.17	high_impact	0.25	0.8	58.42	8.67	0.67	P	0.62	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15180	15180	T	G	MI.9251	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	434	145	V	G	gTa/gGa	4.08	1	0	probably_damaging	1	neutral	0.39	neutral	2.63	deleterious	-6.85	deleterious	-5.54	high_impact	5.61	0.92	neutral	0.1	damaging	3.50	23.10	deleterious	0.02	0.35	0.83	disease	0.82	disease	0.68	disease	0.68	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.12	medium_impact	3.9	high_impact	0.30	0.8	58.42	8.67	0.67	P	0.96	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15182	15182	A	T	MI.9252	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	436	146	I	F	Att/Ttt	-14.27	0	0	probably_damaging	0.99	neutral	0.63	neutral	3	deleterious	-3	deleterious	-3.17	high_impact	5.6	0.95	neutral	0.1	damaging	2.07	16.67	deleterious	0.05	0.35	0.84	disease	0.86	disease	0.69	disease	0.68	disease	4	0.99	deleterious	0.32	neutral	2	deleterious	0.84	deleterious	-2.59	low_impact	0.35	medium_impact	3.89	high_impact	0.68	0.85	59.21	8.77	0.64	P	0.97	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15182	15182	A	C	MI.9253	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	436	146	I	L	Att/Ctt	-14.27	0	0	probably_damaging	0.95	neutral	0.7	neutral	3.09	neutral	-1.59	neutral	-1.58	high_impact	4.36	0.96	neutral	0.1	damaging	1.86	15.33	deleterious	0.18	0.45	0.58	disease	0.72	disease	0.62	disease	0.66	disease	3	0.94	neutral	0.38	neutral	2	deleterious	0.61	deleterious	-1.92	low_impact	0.42	medium_impact	2.77	high_impact	0.63	0.8	59.21	8.77	0.29	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15182	15182	A	G	MI.9254	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	436	146	I	V	Att/Gtt	-14.27	0	0	possibly_damaging	0.88	neutral	1	neutral	3.06	neutral	-1.56	neutral	-0.79	high_impact	4.36	0.95	neutral	0.13	damaging	1.11	11.26	neutral	0.49	0.55	0.41	neutral	0.53	disease	0.59	disease	0.64	disease	3	0.88	neutral	0.56	deleterious	1	deleterious	0.53	deleterious	-1.54	low_impact	1.85	high_impact	2.77	high_impact	0.68	0.85	59.21	8.77	0.27	N	0.83	polymorphism	1	0.05	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15183	15183	T	G	MI.9255	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	437	146	I	S	aTt/aGt	6.84	1	0	probably_damaging	1	neutral	0.52	neutral	3	neutral	-2.84	deleterious	-4.74	high_impact	5.6	0.94	neutral	0.1	damaging	3.91	23.50	deleterious	0.02	0.35	0.86	disease	0.88	disease	0.66	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.24	medium_impact	3.89	high_impact	0.46	0.8	59.21	8.77	0.74	P	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15183	15183	T	A	MI.9256	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	437	146	I	N	aTt/aAt	6.84	1	0	probably_damaging	1	neutral	0.3	neutral	2.97	deleterious	-3.97	deleterious	-5.55	high_impact	5.05	0.94	neutral	0.11	damaging	4.22	23.90	deleterious	0.04	0.35	0.93	disease	0.87	disease	0.69	disease	0.66	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.02	medium_impact	3.39	high_impact	0.63	0.8	59.21	8.77	0.74	P	0.99	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15183	15183	T	C	MI.9257	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	437	146	I	T	aTt/aCt	6.84	1	0	probably_damaging	1	neutral	0.62	neutral	3.07	neutral	-2.16	deleterious	-3.95	high_impact	5.25	0.94	neutral	0.1	damaging	2.99	22.20	deleterious	0.03	0.35	0.62	disease	0.8	disease	0.65	disease	0.67	disease	3	1	deleterious	0.31	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.34	medium_impact	3.57	high_impact	0.35	0.8	59.21	8.77	0.7	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15184	15184	T	G	MI.9258	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	438	146	I	M	atT/atG	5.69	1	0.02	probably_damaging	1	neutral	0.23	neutral	3.02	neutral	-2.53	neutral	-2.38	high_impact	5.25	0.95	neutral	0.11	damaging	2.98	22.20	deleterious	0.07	0.35	0.81	disease	0.71	disease	0.62	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.06	medium_impact	3.57	high_impact	0.65	0.8	59.21	8.77	0.71	P	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15184	15184	T	A	MI.9259	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	438	146	I	M	atT/atA	5.69	1	0.02	probably_damaging	1	neutral	0.23	neutral	3.02	neutral	-2.53	neutral	-2.38	high_impact	5.25	0.95	neutral	0.11	damaging	3.27	22.80	deleterious	0.07	0.35	0.81	disease	0.71	disease	0.62	disease	0.64	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.06	medium_impact	3.57	high_impact	0.65	0.8	59.21	8.77	0.73	P	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8961	8961	A	T	MI.926	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	435	145	E	D	gaA/gaT	6.84	1	0	probably_damaging	0.99	deleterious	0	neutral	3.74	deleterious	-4.91	deleterious	-2.76	high_impact	4.63	0.62	neutral	0.57	neutral	3.81	23.40	deleterious	0.38	0.65	0.82	disease	0.58	disease	0.77	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.63	0.9	49.12	8.84	0.66	P	0.87	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15185	15185	A	T	MI.9260	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	439	147	T	S	Aca/Tca	-4.63	0	0	possibly_damaging	0.49	neutral	0.48	neutral	3.13	neutral	-1.88	deleterious	-3.15	high_impact	4.41	0.86	neutral	0.09	damaging	2.87	21.70	deleterious	0.28	0.45	0.66	disease	0.78	disease	0.65	disease	0.66	disease	3	0.51	neutral	0.5	deleterious	1	deleterious	0.51	deleterious	-0.72	medium_impact	0.2	medium_impact	2.81	high_impact	0.74	0.85	58.16	8.74	0.35	N	0.81	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15185	15185	A	C	MI.9261	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	439	147	T	P	Aca/Cca	-4.63	0	0	probably_damaging	0.94	neutral	0.32	neutral	3.02	deleterious	-3.55	deleterious	-4.76	high_impact	5.26	0.88	neutral	0.06	damaging	3.37	22.90	deleterious	0.04	0.35	0.87	disease	0.86	disease	0.78	disease	0.65	disease	3	0.95	neutral	0.19	neutral	2	deleterious	0.84	deleterious	-1.85	low_impact	0.05	medium_impact	3.58	high_impact	0.50	0.8	58.16	8.74	0.72	P	0.95	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15185	15185	A	G	MI.9262	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	439	147	T	A	Aca/Gca	-4.63	0	0	benign	0.34	neutral	0.63	neutral	3.24	neutral	-1.69	deleterious	-3.94	high_impact	4.92	0.87	neutral	0.12	damaging	3.00	22.20	deleterious	0.14	0.4	0.47	neutral	0.71	disease	0.63	disease	0.64	disease	3	0.3	neutral	0.65	deleterious	-2	neutral	0.37	neutral	-0.46	medium_impact	0.35	medium_impact	3.27	high_impact	0.31	0.8	58.16	8.74	0.52	N	0.59	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15186	15186	C	A	MI.9263	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	440	147	T	K	aCa/aAa	5.46	1	0	possibly_damaging	0.66	neutral	0.25	neutral	3.1	neutral	-2.98	deleterious	-4.75	high_impact	5.05	0.86	neutral	0.07	damaging	4.18	23.80	deleterious	0.05	0.35	0.89	disease	0.89	disease	0.76	disease	0.62	disease	2	0.78	neutral	0.3	neutral	1	deleterious	0.77	deleterious	-1	medium_impact	-0.04	medium_impact	3.39	high_impact	0.51	0.8	58.16	8.74	0.74	P	0.97	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15186	15186	C	T	MI.9264	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	440	147	T	M	aCa/aTa	5.46	1	0	possibly_damaging	0.44	neutral	0.22	neutral	3.03	deleterious	-3.32	deleterious	-4.74	high_impact	5.61	0.86	neutral	0.13	damaging	3.91	23.50	deleterious	0.06	0.35	0.93	disease	0.85	disease	0.69	disease	0.6	disease	2	0.75	neutral	0.39	neutral	1	deleterious	0.50	deleterious	-0.63	medium_impact	-0.08	medium_impact	3.9	high_impact	0.58	0.8	58.16	8.74	0.68	P	0.96	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15188	15188	A	G	MI.9265	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	442	148	N	D	Aac/Gac	-20	0	0	probably_damaging	0.99	neutral	0.19	neutral	3.03	neutral	-2.45	deleterious	-3.96	high_impact	5.55	0.79	neutral	0.34	neutral	3.39	23.00	deleterious	0.26	0.45	0.52	disease	0.82	disease	0.76	disease	0.7	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.80	deleterious	-2.59	low_impact	-0.12	medium_impact	3.85	high_impact	0.37	0.8	58.68	8.71	0.68	P	0.96	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15188	15188	A	C	MI.9266	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	442	148	N	H	Aac/Cac	-20	0	0	probably_damaging	1	neutral	0.51	neutral	3	deleterious	-4.06	deleterious	-3.96	high_impact	5.21	0.82	neutral	0.19	damaging	2.94	22.00	deleterious	0.13	0.4	0.81	disease	0.85	disease	0.75	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.23	medium_impact	3.54	high_impact	0.31	0.8	58.68	8.71	0.7	P	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15188	15188	A	T	MI.9267	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	442	148	N	Y	Aac/Tac	-20	0	0	probably_damaging	1	neutral	1	neutral	2.99	deleterious	-4.8	deleterious	-6.33	high_impact	4.86	0.83	neutral	0.32	neutral	3.59	23.20	deleterious	0.05	0.35	0.89	disease	0.91	disease	0.7	disease	0.62	disease	2	1	deleterious	0.5	deleterious	2	deleterious	0.88	deleterious	-3.53	low_impact	1.85	high_impact	3.22	high_impact	0.23	0.8	58.68	8.71	0.58	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15189	15189	A	G	MI.9268	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	443	148	N	S	aAc/aGc	8.44	1	0	probably_damaging	0.98	neutral	0.51	neutral	3.18	neutral	-1.75	deleterious	-3.94	medium_impact	3.09	0.83	neutral	0.39	neutral	1.15	11.46	neutral	0.29	0.45	0.28	neutral	0.84	disease	0.53	disease	0.66	disease	3	0.97	neutral	0.27	neutral	1	deleterious	0.77	deleterious	-2.31	low_impact	0.23	medium_impact	1.61	medium_impact	0.36	0.8	58.68	8.71	0.5	N	0.91	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15189	15189	A	C	MI.9269	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	443	148	N	T	aAc/aCc	8.44	1	0	probably_damaging	1	neutral	0.91	neutral	3.04	deleterious	-3.22	deleterious	-4.73	high_impact	4.66	0.86	neutral	0.42	neutral	2.90	21.90	deleterious	0.12	0.4	0.71	disease	0.85	disease	0.63	disease	0.67	disease	3	0.99	deleterious	0.46	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.77	medium_impact	3.04	high_impact	0.33	0.8	58.68	8.71	0.58	P	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8961	8961	A	C	MI.927	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	435	145	E	D	gaA/gaC	6.84	1	0	probably_damaging	0.99	deleterious	0	neutral	3.74	deleterious	-4.91	deleterious	-2.76	high_impact	4.63	0.62	neutral	0.57	neutral	3.71	23.30	deleterious	0.38	0.65	0.82	disease	0.58	disease	0.77	disease	0.75	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.63	0.9	49.12	8.84	0.66	P	0.87	disease_causing	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15189	15189	A	T	MI.9270	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	443	148	N	I	aAc/aTc	8.44	1	0	probably_damaging	1	neutral	0.63	neutral	3	deleterious	-5.78	deleterious	-7.12	high_impact	5	0.84	neutral	0.41	neutral	3.62	23.20	deleterious	0.06	0.35	0.87	disease	0.93	disease	0.67	disease	0.63	disease	3	1	deleterious	0.32	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.35	medium_impact	3.35	high_impact	0.23	0.8	58.68	8.71	0.69	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15190	15190	C	A	MI.9271	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	444	148	N	K	aaC/aaA	5.46	1	0	probably_damaging	1	neutral	0.28	neutral	3.1	neutral	-2.66	deleterious	-4.75	high_impact	4.75	0.83	neutral	0.27	damaging	4.23	23.90	deleterious	0.15	0.4	0.63	disease	0.88	disease	0.76	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0	medium_impact	3.12	high_impact	0.48	0.8	58.68	8.71	0.75	P	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15190	15190	C	G	MI.9272	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	444	148	N	K	aaC/aaG	5.46	1	0	probably_damaging	1	neutral	0.28	neutral	3.1	neutral	-2.66	deleterious	-4.75	high_impact	4.75	0.83	neutral	0.27	damaging	3.81	23.40	deleterious	0.15	0.4	0.63	disease	0.88	disease	0.76	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0	medium_impact	3.12	high_impact	0.48	0.8	58.68	8.71	0.74	P	1.00	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15191	15191	T	G	MI.9273	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	445	149	L	V	Tta/Gta	-1.88	0	0.01	probably_damaging	0.99	neutral	0.56	neutral	2.92	neutral	-1.44	neutral	-2.33	high_impact	4.54	0.84	neutral	0.47	neutral	2.99	22.20	deleterious	0.23	0.45	NA	NA	0.69	disease	0.63	disease	0.65	disease	3	0.99	deleterious	0.29	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	0.28	medium_impact	2.93	high_impact	0.47	0.8	58.16	8.78	0.38	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15191	15191	T	A	MI.9274	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	445	149	L	M	Tta/Ata	-1.88	0	0.01	probably_damaging	1	neutral	0.22	neutral	2.81	deleterious	-3.18	neutral	-1.43	high_impact	3.6	0.76	neutral	0.44	neutral	3.69	23.30	deleterious	0.21	0.45	NA	NA	0.61	disease	0.55	disease	0.48	neutral	0	1	deleterious	0.11	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	-0.08	medium_impact	2.08	high_impact	0.46	0.8	58.16	8.78	0.4	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15192	15192	T	G	MI.9275	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	446	149	L	W	tTa/tGa	0.18	0.02	0	probably_damaging	1	neutral	0.19	neutral	2.79	deleterious	-3.78	deleterious	-4.7	high_impact	5.58	0.84	neutral	0.35	neutral	3.73	23.30	deleterious	0.04	0.35	NA	NA	0.79	disease	0.67	disease	0.65	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.12	medium_impact	3.87	high_impact	0.24	0.8	58.16	8.78	0.64	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15192	15192	T	C	MI.9276	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	446	149	L	S	tTa/tCa	0.18	0.02	0	probably_damaging	1	neutral	0.43	neutral	2.8	deleterious	-3.36	deleterious	-4.68	high_impact	4.67	0.83	neutral	0.45	neutral	3.64	23.20	deleterious	0.02	0.35	NA	NA	0.82	disease	0.64	disease	0.65	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.16	medium_impact	3.05	high_impact	0.42	0.8	58.16	8.78	0.53	N	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15193	15193	A	T	MI.9277	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	447	149	L	F	ttA/ttT	5.69	0.87	0	probably_damaging	1	neutral	0.7	neutral	2.85	neutral	-2.26	deleterious	-3.13	high_impact	3.58	0.91	neutral	0.45	neutral	3.45	23.00	deleterious	0.13	0.4	NA	NA	0.8	disease	0.58	disease	0.64	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.42	medium_impact	2.06	high_impact	0.51	0.8	58.16	8.78	0.41	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15193	15193	A	C	MI.9278	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	447	149	L	F	ttA/ttC	5.69	0.87	0	probably_damaging	1	neutral	0.7	neutral	2.85	neutral	-2.26	deleterious	-3.13	high_impact	3.58	0.91	neutral	0.45	neutral	3.32	22.90	deleterious	0.13	0.4	NA	NA	0.8	disease	0.58	disease	0.64	disease	3	1	deleterious	0.35	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.42	medium_impact	2.06	high_impact	0.51	0.8	58.16	8.78	0.41	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15194	15194	C	G	MI.9279	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	448	150	L	V	Cta/Gta	-10.83	0	0	probably_damaging	0.98	neutral	0.46	neutral	3.07	neutral	-0.66	neutral	-2.1	medium_impact	3.01	0.95	neutral	0.1	damaging	1.67	14.23	neutral	0.24	0.45	NA	NA	0.62	disease	0.35	neutral	0.36	neutral	3	0.98	neutral	0.24	neutral	1	deleterious	0.79	deleterious	-2.31	low_impact	0.18	medium_impact	1.54	medium_impact	0.46	0.8	51.58	8.37	0.26	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8962	8962	A	G	MI.928	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	436	146	T	A	Acc/Gcc	0.59	0.99	0.01	probably_damaging	0.99	neutral	0.05	neutral	4.26	neutral	-0.37	deleterious	-4.58	high_impact	3.55	0.69	neutral	0.52	neutral	3.40	23.00	deleterious	0.49	0.65	0.46	neutral	0.57	disease	0.6	disease	0.63	disease	3	1	deleterious	0.03	neutral	2	deleterious	0.71	deleterious	-2.65	low_impact	-0.43	medium_impact	1.95	medium_impact	0.46	0.9	50	8.58	0.49	P	0.63	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15194	15194	C	A	MI.9280	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	448	150	L	M	Cta/Ata	-10.83	0	0	probably_damaging	1	neutral	0.18	neutral	3.01	neutral	-1.18	neutral	-1.27	medium_impact	2.64	0.97	neutral	0.29	neutral	3.50	23.10	deleterious	0.23	0.45	NA	NA	0.52	disease	0.35	neutral	0.19	neutral	6	1	deleterious	0.09	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	-0.14	medium_impact	1.2	medium_impact	0.52	0.8	51.58	8.37	0.4	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15195	15195	T	A	MI.9281	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	449	150	L	Q	cTa/cAa	-1.88	0	0	probably_damaging	1	neutral	0.2	neutral	2.88	deleterious	-4	deleterious	-4.27	high_impact	4.79	0.94	neutral	0.07	damaging	4.12	23.80	deleterious	0.02	0.35	NA	NA	0.8	disease	0.56	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.1	medium_impact	3.16	high_impact	0.23	0.8	51.58	8.37	0.61	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15195	15195	T	C	MI.9282	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	449	150	L	P	cTa/cCa	-1.88	0	0	probably_damaging	1	neutral	0.21	neutral	2.87	deleterious	-4.39	deleterious	-5.09	high_impact	4.99	0.94	neutral	0.06	damaging	3.87	23.50	deleterious	0.01	0.35	NA	NA	0.84	disease	0.69	disease	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.09	medium_impact	3.34	high_impact	0.22	0.8	51.58	8.37	0.62	P	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15195	15195	T	G	MI.9283	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	449	150	L	R	cTa/cGa	-1.88	0	0	probably_damaging	1	neutral	0.24	neutral	2.88	deleterious	-3.82	deleterious	-4.31	high_impact	5.34	0.94	neutral	0.06	damaging	4.02	23.60	deleterious	0.01	0.35	NA	NA	0.89	disease	0.68	disease	0.72	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.05	medium_impact	3.66	high_impact	0.15	0.8	51.58	8.37	0.68	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15197	15197	T	C	MI.9284	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	451	151	S	P	Tcc/Ccc	-7.38	0	0	probably_damaging	1	neutral	0.26	neutral	2.92	deleterious	-3.64	deleterious	-4.03	high_impact	4.86	0.9	neutral	0.06	damaging	3.51	23.10	deleterious	0.05	0.35	NA	NA	0.85	disease	0.8	disease	0.7	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.02	medium_impact	3.22	high_impact	0.15	0.8	58.16	8.74	0.72	P	1.00	disease_causing_automatic	0	0.18	rs207460001	Pathogenic	Exercise_intolerance	24721	MedGen:C0241885	.	.	.	.	T15197C	EXIT	-	+	Reported	2	P	P	P	damaging
chrM	15197	15197	T	G	MI.9285	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	451	151	S	A	Tcc/Gcc	-7.38	0	0	probably_damaging	0.98	neutral	0.59	neutral	2.97	neutral	-1.9	neutral	-2.4	high_impact	5.2	0.89	neutral	0.12	damaging	1.85	15.26	deleterious	0.18	0.45	NA	NA	0.62	disease	0.68	disease	0.65	disease	3	0.98	neutral	0.31	neutral	2	deleterious	0.77	deleterious	-2.31	low_impact	0.31	medium_impact	3.53	high_impact	0.38	0.8	58.16	8.74	0.58	N	0.46	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15197	15197	T	A	MI.9286	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	451	151	S	T	Tcc/Acc	-7.38	0	0	probably_damaging	0.96	neutral	0.5	neutral	2.99	neutral	-1.65	neutral	-2.4	medium_impact	3.17	0.88	neutral	0.08	damaging	1.87	15.38	deleterious	0.21	0.45	NA	NA	0.72	disease	0.64	disease	0.64	disease	3	0.96	neutral	0.27	neutral	1	deleterious	0.81	deleterious	-2.02	low_impact	0.22	medium_impact	1.69	medium_impact	0.53	0.8	58.16	8.74	0.23	N	0.70	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15198	15198	C	A	MI.9287	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	452	151	S	Y	tCc/tAc	4.54	1	0	probably_damaging	1	neutral	1	neutral	2.92	deleterious	-3.67	deleterious	-4.82	high_impact	4.22	0.91	neutral	0.06	damaging	4.00	23.60	deleterious	0.05	0.35	NA	NA	0.87	disease	0.71	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.87	deleterious	-3.53	low_impact	1.85	high_impact	2.64	high_impact	0.13	0.8	58.16	8.74	0.41	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15198	15198	C	G	MI.9288	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	452	151	S	C	tCc/tGc	4.54	1	0	probably_damaging	1	neutral	0.17	neutral	2.9	deleterious	-5.52	deleterious	-4.03	high_impact	5.2	0.87	neutral	0.05	damaging	3.38	22.90	deleterious	0.07	0.35	NA	NA	0.82	disease	0.68	disease	0.66	disease	3	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.15	medium_impact	3.53	high_impact	0.24	0.8	58.16	8.74	0.65	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15198	15198	C	T	MI.9289	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	452	151	S	F	tCc/tTc	4.54	1	0	probably_damaging	1	neutral	0.73	neutral	2.91	deleterious	-4.57	deleterious	-4.81	high_impact	5	0.91	neutral	0.07	damaging	4.00	23.60	deleterious	0.05	0.35	NA	NA	0.9	disease	0.72	disease	0.69	disease	4	1	deleterious	0.37	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.46	medium_impact	3.35	high_impact	0.06	0.8	58.16	8.74	0.69	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8962	8962	A	C	MI.929	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	436	146	T	P	Acc/Ccc	0.59	0.99	0.01	probably_damaging	1	deleterious	0	neutral	4.19	neutral	-2.95	deleterious	-5.57	high_impact	4.24	0.57	damaging	0.41	neutral	3.44	23.00	deleterious	0.17	0.65	0.86	disease	0.81	disease	0.74	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-1.4	low_impact	2.54	high_impact	0.64	0.9	50	8.58	0.42	N	0.99	disease_causing	1	0.29	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15200	15200	G	A	MI.9290	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	454	152	A	T	Gcc/Acc	-1.88	0	0	probably_damaging	1	neutral	0.4	neutral	3.07	neutral	-2.23	deleterious	-3.2	medium_impact	2.8	0.94	neutral	0.11	damaging	3.90	23.50	deleterious	0.12	0.4	0.63	disease	0.85	disease	0.48	neutral	0.67	disease	3	1	deleterious	0.2	neutral	1	deleterious	0.85	deleterious	-3.53	low_impact	0.13	medium_impact	1.35	medium_impact	0.76	0.85	58.16	8.78	0.3	N	0.79	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15200	15200	G	C	MI.9291	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	454	152	A	P	Gcc/Ccc	-1.88	0	0	probably_damaging	1	neutral	0.21	neutral	2.99	deleterious	-4.12	deleterious	-4.05	high_impact	4.66	0.95	neutral	0.04	damaging	3.71	23.30	deleterious	0.04	0.35	0.81	disease	0.89	disease	0.77	disease	0.73	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.09	medium_impact	3.04	high_impact	0.50	0.8	58.16	8.78	0.64	P	0.98	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15200	15200	G	T	MI.9292	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	454	152	A	S	Gcc/Tcc	-1.88	0	0	probably_damaging	1	neutral	0.43	neutral	3.22	neutral	-0.55	neutral	-2.41	high_impact	3.65	0.94	neutral	0.09	damaging	3.33	22.90	deleterious	0.16	0.45	0.58	disease	0.87	disease	0.57	disease	0.69	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.16	medium_impact	2.12	high_impact	0.38	0.8	58.16	8.78	0.31	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15201	15201	C	A	MI.9293	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	455	152	A	D	gCc/gAc	5.92	1	0	probably_damaging	1	neutral	0.21	neutral	3.01	neutral	-2.86	deleterious	-4.84	high_impact	5.12	0.93	neutral	0.08	damaging	4.37	24.10	deleterious	0.03	0.35	0.75	disease	0.93	disease	0.76	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.09	medium_impact	3.46	high_impact	0.29	0.8	58.16	8.78	0.74	P	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15201	15201	C	T	MI.9294	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	455	152	A	V	gCc/gTc	5.92	1	0	probably_damaging	1	neutral	0.51	neutral	3.06	neutral	-2.67	deleterious	-3.23	medium_impact	3.06	0.95	neutral	0.11	damaging	4.14	23.80	deleterious	0.1	0.4	0.47	neutral	0.88	disease	0.6	disease	0.68	disease	4	1	deleterious	0.26	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.23	medium_impact	1.59	medium_impact	0.74	0.85	58.16	8.78	0.5	N	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15201	15201	C	G	MI.9295	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	455	152	A	G	gCc/gGc	5.92	1	0	probably_damaging	0.99	neutral	0.33	neutral	3.1	neutral	-1.43	deleterious	-3.23	high_impact	4.78	0.94	neutral	0.14	damaging	2.26	17.92	deleterious	0.18	0.45	0.54	disease	0.83	disease	0.66	disease	0.69	disease	4	0.99	deleterious	0.17	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.06	medium_impact	3.15	high_impact	0.65	0.8	58.16	8.78	0.71	P	0.83	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15203	15203	A	T	MI.9296	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	457	153	I	F	Atc/Ttc	-8.99	0	0	benign	0.33	neutral	0.68	neutral	2.98	deleterious	-3.22	deleterious	-2.7	medium_impact	2.77	0.95	neutral	0.36	neutral	2.08	16.71	deleterious	0.14	0.4	0.82	disease	0.83	disease	0.48	neutral	0.54	disease	1	0.26	neutral	0.68	deleterious	-3	neutral	0.59	deleterious	-0.44	medium_impact	0.4	medium_impact	1.32	medium_impact	0.51	0.8	20	15.17	0.2	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15203	15203	A	C	MI.9297	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	457	153	I	L	Atc/Ctc	-8.99	0	0	benign	0.03	neutral	0.69	neutral	3.05	neutral	-1.81	neutral	-1.37	medium_impact	2.9	0.97	neutral	0.36	neutral	1.86	15.31	deleterious	0.27	0.45	0.49	neutral	0.74	disease	0.43	neutral	0.48	neutral	0	0.26	neutral	0.83	deleterious	-3	neutral	0.24	neutral	0.68	medium_impact	0.41	medium_impact	1.44	medium_impact	0.52	0.8	20	15.17	0.21	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15203	15203	A	G	MI.9298	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	457	153	I	V	Atc/Gtc	-8.99	0	0	benign	0	neutral	0.57	neutral	3.08	neutral	-1.39	neutral	-0.22	low_impact	0.94	0.99	neutral	0.69	neutral	-0.33	0.58	neutral	0.46	0.55	0.34	neutral	0.13	neutral	0.41	neutral	0.28	neutral	5	0.43	neutral	0.79	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.29	medium_impact	-0.34	medium_impact	0.54	0.8	20	15.17	0.34	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15204	15204	T	C	MI.9299	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	458	153	I	T	aTc/aCc	1.56	0.84	0.01	benign	0.31	neutral	0.45	neutral	2.95	neutral	-2.19	deleterious	-3.1	medium_impact	2.35	0.98	neutral	0.54	neutral	1.64	14.07	neutral	0.07	0.35	0.54	disease	0.75	disease	0.57	disease	0.51	disease	0	0.46	neutral	0.57	deleterious	-3	neutral	0.37	neutral	-0.41	medium_impact	0.18	medium_impact	0.94	medium_impact	0.28	0.8	20	15.17	0.3	N	0.99	polymorphism	1	0.04	rs28357687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	8568	8568	C	G	MI.93	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	42	14	I	M	atC/atG	1.75	0.01	0	possibly_damaging	0.82	neutral	0.26	neutral	4.59	neutral	-1.38	neutral	-0.03	neutral_impact	0.62	0.91	neutral	0.9	neutral	3.74	23.30	deleterious	0.62	0.7	0.37	neutral	0.21	neutral	0.32	neutral	0.36	neutral	3	0.87	neutral	0.22	neutral	-3	neutral	0.53	deleterious	-1.38	low_impact	0.04	medium_impact	-0.57	medium_impact	0.83	0.9	13.72	12.42	0.54	P	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8962	8962	A	T	MI.930	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	436	146	T	S	Acc/Tcc	0.59	0.99	0.01	probably_damaging	0.99	neutral	0.14	neutral	4.22	neutral	-1.13	deleterious	-3.66	medium_impact	2.23	0.75	neutral	0.54	neutral	3.14	22.60	deleterious	0.5	0.65	0.64	disease	0.55	disease	0.46	neutral	0.45	neutral	1	0.99	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-2.65	low_impact	-0.15	medium_impact	0.81	medium_impact	0.77	0.9	50	8.58	0.45	N	0.88	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15204	15204	T	A	MI.9300	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	458	153	I	N	aTc/aAc	1.56	0.84	0.01	possibly_damaging	0.87	neutral	0.33	neutral	2.85	deleterious	-5.13	deleterious	-4.97	high_impact	4.73	0.93	neutral	0.36	neutral	4.02	23.60	deleterious	0.14	0.4	0.93	disease	0.89	disease	0.66	disease	0.76	disease	5	0.88	neutral	0.23	neutral	1	deleterious	0.83	deleterious	-1.5	low_impact	0.06	medium_impact	3.1	high_impact	0.36	0.8	20	15.17	0.63	P	0.99	polymorphism	1	0.19	rs28357687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15204	15204	T	G	MI.9301	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	458	153	I	S	aTc/aGc	1.56	0.84	0.01	possibly_damaging	0.6	neutral	0.44	neutral	2.87	deleterious	-3.8	deleterious	-4.1	high_impact	5.08	0.94	neutral	0.37	neutral	2.66	20.50	deleterious	0.05	0.35	0.86	disease	0.89	disease	0.63	disease	0.75	disease	5	0.61	neutral	0.42	neutral	1	deleterious	0.61	deleterious	-0.9	medium_impact	0.17	medium_impact	3.42	high_impact	0.24	0.8	20	15.17	0.62	P	0.98	polymorphism	1	0.09	rs28357687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15205	15205	C	A	MI.9302	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	459	153	I	M	atC/atA	5.69	0.98	0	possibly_damaging	0.6	neutral	0.21	neutral	2.88	neutral	-2.83	neutral	-1.86	medium_impact	2.87	0.93	neutral	0.39	neutral	2.14	17.11	deleterious	0.25	0.45	0.79	disease	0.68	disease	0.57	disease	0.62	disease	2	0.79	neutral	0.31	neutral	0	NA	0.48	deleterious	-0.9	medium_impact	-0.09	medium_impact	1.41	medium_impact	0.51	0.8	20	15.17	0.56	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15205	15205	C	G	MI.9303	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	459	153	I	M	atC/atG	5.69	0.98	0	possibly_damaging	0.6	neutral	0.21	neutral	2.88	neutral	-2.83	neutral	-1.86	medium_impact	2.87	0.93	neutral	0.39	neutral	1.70	14.39	neutral	0.25	0.45	0.79	disease	0.68	disease	0.57	disease	0.62	disease	2	0.79	neutral	0.31	neutral	0	NA	0.48	deleterious	-0.9	medium_impact	-0.09	medium_impact	1.41	medium_impact	0.51	0.8	20	15.17	0.56	N	0.83	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15206	15206	C	A	MI.9304	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	460	154	P	T	Cca/Aca	-1.88	0	0	probably_damaging	1	neutral	0.39	neutral	2.16	deleterious	-7.47	deleterious	-6.44	high_impact	5.29	0.92	neutral	0.11	damaging	3.24	22.80	deleterious	0.1	0.4	0.79	disease	0.86	disease	0.73	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.12	medium_impact	3.61	high_impact	0.49	0.8	60.26	8.68	0.66	P	0.96	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15206	15206	C	G	MI.9305	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	460	154	P	A	Cca/Gca	-1.88	0	0	probably_damaging	0.98	neutral	0.51	neutral	2.18	deleterious	-6.45	deleterious	-6.44	high_impact	5.64	0.94	neutral	0.15	damaging	1.24	11.97	neutral	0.11	0.4	0.71	disease	0.77	disease	0.72	disease	0.69	disease	4	0.97	neutral	0.27	neutral	2	deleterious	0.82	deleterious	-2.31	low_impact	0.23	medium_impact	3.93	high_impact	0.65	0.8	60.26	8.68	0.6	P	0.84	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15206	15206	C	T	MI.9306	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	460	154	P	S	Cca/Tca	-1.88	0	0	probably_damaging	1	neutral	0.4	neutral	2.17	deleterious	-6.22	deleterious	-6.44	high_impact	5.64	0.93	neutral	0.1	damaging	3.46	23.00	deleterious	0.08	0.35	0.75	disease	0.87	disease	0.72	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.13	medium_impact	3.93	high_impact	0.15	0.8	60.26	8.68	0.67	P	0.90	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15207	15207	C	G	MI.9307	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	461	154	P	R	cCa/cGa	5.46	0.99	0	probably_damaging	1	neutral	0.34	neutral	2.15	deleterious	-7.82	deleterious	-7.26	high_impact	5.64	0.93	neutral	0.08	damaging	3.46	23.00	deleterious	0.04	0.35	0.87	disease	0.92	disease	0.81	disease	0.7	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.07	medium_impact	3.93	high_impact	0.31	0.8	60.26	8.68	0.69	P	0.80	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15207	15207	C	A	MI.9308	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	461	154	P	Q	cCa/cAa	5.46	0.99	0	probably_damaging	1	neutral	0.29	neutral	2.15	deleterious	-8	deleterious	-6.46	high_impact	5.64	0.93	neutral	0.09	damaging	3.96	23.60	deleterious	0.08	0.35	0.89	disease	0.89	disease	0.75	disease	0.67	disease	3	1	deleterious	0.15	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.01	medium_impact	3.93	high_impact	0.28	0.8	60.26	8.68	0.71	P	0.86	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15207	15207	C	T	MI.9309	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	461	154	P	L	cCa/cTa	5.46	0.99	0	probably_damaging	1	neutral	0.65	neutral	2.15	deleterious	-7.41	deleterious	-8.07	high_impact	4.95	0.94	neutral	0.07	damaging	4.21	23.90	deleterious	0.04	0.35	0.72	disease	0.92	disease	0.7	disease	0.72	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.37	medium_impact	3.3	high_impact	0.67	0.85	60.26	8.68	0.63	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8963	8963	C	A	MI.931	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	437	146	T	N	aCc/aAc	8.69	1	0	probably_damaging	1	deleterious	0	neutral	4.19	neutral	-2.63	deleterious	-4.62	high_impact	4.24	0.66	neutral	0.46	neutral	3.82	23.40	deleterious	0.4	0.65	0.83	disease	0.72	disease	0.58	disease	0.69	disease	4	1	deleterious	0	neutral	6	deleterious	0.76	deleterious	-3.6	low_impact	-1.4	low_impact	2.54	high_impact	0.82	0.9	50	8.58	0.51	P	0.90	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15209	15209	T	A	MI.9310	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	463	155	Y	N	Tac/Aac	-14.72	0	0.01	probably_damaging	1	neutral	0.3	neutral	3.06	neutral	-1.49	deleterious	-7.25	high_impact	4.89	0.83	neutral	0.46	neutral	3.65	23.20	deleterious	0.08	0.35	0.69	disease	0.89	disease	0.7	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.02	medium_impact	3.25	high_impact	0.10	0.8	58.42	8.68	0.62	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15209	15209	T	G	MI.9311	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	463	155	Y	D	Tac/Gac	-14.72	0	0.01	probably_damaging	1	neutral	0.2	neutral	3.05	neutral	-2.68	deleterious	-8.05	high_impact	5.45	0.79	neutral	0.38	neutral	3.61	23.20	deleterious	0.04	0.35	0.79	disease	0.9	disease	0.79	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.1	medium_impact	3.76	high_impact	0.10	0.8	58.42	8.68	0.69	P	1.00	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15209	15209	T	C	MI.9312	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	463	155	Y	H	Tac/Cac	-14.72	0	0.01	probably_damaging	1	neutral	0.54	neutral	3.05	neutral	-2.03	deleterious	-4.03	high_impact	4.64	0.82	neutral	0.38	neutral	3.12	22.60	deleterious	0.12	0.4	0.7	disease	0.87	disease	0.79	disease	0.74	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.26	medium_impact	3.02	high_impact	0.13	0.8	58.42	8.68	0.62	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	T15209C	Prader-Willi syndrome	+	-	Reported	1	.	P	P	damaging
chrM	15210	15210	A	T	MI.9313	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	464	155	Y	F	tAc/tTc	7.3	1	0	probably_damaging	0.97	neutral	0.7	neutral	3.17	neutral	1.51	deleterious	-3.21	medium_impact	2.8	0.87	neutral	0.68	neutral	1.39	12.72	neutral	0.26	0.45	0.27	neutral	0.87	disease	0.64	disease	0.69	disease	4	0.97	neutral	0.37	neutral	1	deleterious	0.77	deleterious	-2.14	low_impact	0.42	medium_impact	1.35	medium_impact	0.32	0.8	58.42	8.68	0.5	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15210	15210	A	C	MI.9314	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	464	155	Y	S	tAc/tCc	7.3	1	0	probably_damaging	1	neutral	0.4	neutral	3.08	neutral	-0.42	deleterious	-7.23	high_impact	4.89	0.83	neutral	0.49	neutral	3.21	22.70	deleterious	0.07	0.35	0.53	disease	0.89	disease	0.71	disease	0.73	disease	5	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.13	medium_impact	3.25	high_impact	0.12	0.8	58.42	8.68	0.68	P	1.00	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15210	15210	A	G	MI.9315	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	464	155	Y	C	tAc/tGc	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	3.06	neutral	-1.85	deleterious	-7.26	high_impact	4.64	0.84	neutral	0.34	neutral	3.27	22.80	deleterious	0.06	0.35	0.72	disease	0.9	disease	0.7	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.14	medium_impact	3.02	high_impact	0.12	0.8	58.42	8.68	0.62	P	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15212	15212	A	C	MI.9316	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	466	156	I	L	Att/Ctt	-2.11	0	0	possibly_damaging	0.84	neutral	0.63	neutral	3.15	neutral	-1.32	neutral	-0.94	low_impact	1.38	0.95	neutral	0.4	neutral	1.65	14.14	neutral	0.29	0.45	0.27	neutral	0.64	disease	0.35	neutral	0.35	neutral	3	0.81	neutral	0.4	neutral	-3	neutral	0.37	neutral	-1.4	low_impact	0.35	medium_impact	0.06	medium_impact	0.67	0.85	45.53	8.75	0.25	N	0.88	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15212	15212	A	T	MI.9317	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	466	156	I	F	Att/Ttt	-2.11	0	0	probably_damaging	0.97	neutral	0.67	neutral	2.99	deleterious	-3.08	deleterious	-2.67	medium_impact	3.1	0.95	neutral	0.42	neutral	1.67	14.26	neutral	0.14	0.4	0.6	disease	0.82	disease	0.56	disease	0.64	disease	3	0.97	neutral	0.35	neutral	1	deleterious	0.77	deleterious	-2.14	low_impact	0.39	medium_impact	1.62	medium_impact	0.60	0.8	45.53	8.75	0.2	N	0.97	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15212	15212	A	G	MI.9318	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	466	156	I	V	Att/Gtt	-2.11	0	0	possibly_damaging	0.66	neutral	0.52	neutral	3.11	neutral	-0.55	neutral	-0.32	low_impact	0.8	0.98	neutral	0.87	neutral	-0.46	0.28	neutral	0.37	0.5	0.2	neutral	0.12	neutral	0.36	neutral	0.27	neutral	5	0.63	neutral	0.43	neutral	-3	neutral	0.29	neutral	-1	medium_impact	0.24	medium_impact	-0.47	medium_impact	0.43	0.8	45.53	8.75	0.38	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15213	15213	T	C	MI.9319	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	467	156	I	T	aTt/aCt	1.33	0.72	0	probably_damaging	0.99	neutral	0.37	neutral	2.93	deleterious	-3.11	deleterious	-3.06	medium_impact	3.36	0.93	neutral	0.53	neutral	1.55	13.57	neutral	0.07	0.35	0.59	disease	0.71	disease	0.56	disease	0.55	disease	1	0.99	deleterious	0.19	neutral	1	deleterious	0.76	deleterious	-2.59	low_impact	0.1	medium_impact	1.86	medium_impact	0.35	0.8	45.53	8.75	0.33	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8963	8963	C	T	MI.932	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	437	146	T	I	aCc/aTc	8.69	1	0	probably_damaging	1	neutral	0.08	neutral	4.43	neutral	1.18	deleterious	-5.54	medium_impact	2.4	0.71	neutral	0.52	neutral	3.93	23.50	deleterious	0.33	0.65	0.34	neutral	0.84	disease	0.57	disease	0.64	disease	3	1	deleterious	0.04	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.31	medium_impact	0.96	medium_impact	0.68	0.9	50	8.58	0.45	N	0.97	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15213	15213	T	A	MI.9320	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	467	156	I	N	aTt/aAt	1.33	0.72	0	probably_damaging	1	neutral	0.29	neutral	2.89	deleterious	-3.83	deleterious	-4.75	high_impact	4.95	0.93	neutral	0.41	neutral	2.69	20.70	deleterious	0.06	0.35	0.81	disease	0.88	disease	0.62	disease	0.71	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.01	medium_impact	3.3	high_impact	0.21	0.8	45.53	8.75	0.66	P	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15213	15213	T	G	MI.9321	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	467	156	I	S	aTt/aGt	1.33	0.72	0	probably_damaging	0.99	neutral	0.39	neutral	2.92	deleterious	-3.27	deleterious	-3.92	high_impact	3.9	0.94	neutral	0.4	neutral	2.51	19.51	deleterious	0.03	0.35	0.67	disease	0.83	disease	0.63	disease	0.59	disease	2	0.99	deleterious	0.2	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.12	medium_impact	2.35	high_impact	0.24	0.8	45.53	8.75	0.38	N	0.98	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15214	15214	T	A	MI.9322	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	468	156	I	M	atT/atA	7.3	0.98	0	probably_damaging	0.99	neutral	0.22	neutral	2.93	deleterious	-3.26	neutral	-1.13	medium_impact	2.19	0.95	neutral	0.66	neutral	0.71	8.91	deleterious	0.22	0.45	0.4	neutral	0.43	neutral	0.38	neutral	0.45	neutral	1	0.99	deleterious	0.12	neutral	1	deleterious	0.67	deleterious	-2.59	low_impact	-0.08	medium_impact	0.8	medium_impact	0.48	0.8	45.53	8.75	0.61	P	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15214	15214	T	G	MI.9323	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	468	156	I	M	atT/atG	7.3	0.98	0	probably_damaging	0.99	neutral	0.22	neutral	2.93	deleterious	-3.26	neutral	-1.13	medium_impact	2.19	0.95	neutral	0.66	neutral	0.47	7.18	deleterious	0.22	0.45	0.4	neutral	0.43	neutral	0.38	neutral	0.45	neutral	1	0.99	deleterious	0.12	neutral	1	deleterious	0.67	deleterious	-2.59	low_impact	-0.08	medium_impact	0.8	medium_impact	0.48	0.8	45.53	8.75	0.6	P	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15215	15215	G	C	MI.9324	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	469	157	G	R	Ggg/Cgg	-10.37	0	0	probably_damaging	1	neutral	0.35	neutral	2.64	deleterious	-8.38	deleterious	-6.49	high_impact	5.62	0.79	neutral	0.24	damaging	3.86	23.50	deleterious	0.02	0.35	0.83	disease	0.93	disease	0.85	disease	0.72	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	0.08	medium_impact	3.91	high_impact	0.50	0.8	57.11	8.64	0.63	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15215	15215	G	T	MI.9325	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	469	157	G	W	Ggg/Tgg	-10.37	0	0	probably_damaging	1	neutral	0.19	neutral	2.6	deleterious	-11.15	deleterious	-6.5	high_impact	5.62	0.78	neutral	0.25	damaging	4.33	24.00	deleterious	0.04	0.35	0.97	disease	0.95	disease	0.81	disease	0.63	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.12	medium_impact	3.91	high_impact	0.16	0.8	57.11	8.64	0.56	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15216	15216	G	T	MI.9326	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	470	157	G	V	gGg/gTg	4.08	1	0	probably_damaging	1	neutral	0.5	neutral	2.65	deleterious	-9.5	deleterious	-7.3	high_impact	5.28	0.79	neutral	0.37	neutral	3.77	23.40	deleterious	0.02	0.35	0.73	disease	0.93	disease	0.78	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.22	medium_impact	3.6	high_impact	0.16	0.8	57.11	8.64	0.6	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15216	15216	G	C	MI.9327	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	470	157	G	A	gGg/gCg	4.08	1	0	probably_damaging	1	neutral	0.51	neutral	2.68	deleterious	-6.84	deleterious	-4.85	high_impact	5.28	0.8	neutral	0.43	neutral	3.01	22.30	deleterious	0.04	0.35	0.46	neutral	0.84	disease	0.75	disease	0.7	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.23	medium_impact	3.6	high_impact	0.40	0.8	57.11	8.64	0.7	P	0.83	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15216	15216	G	A	MI.9328	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	470	157	G	E	gGg/gAg	4.08	1	0	probably_damaging	1	neutral	0.27	neutral	2.66	deleterious	-7.9	deleterious	-6.49	high_impact	5.08	0.68	neutral	0.32	neutral	3.90	23.50	deleterious	0.03	0.35	0.81	disease	0.93	disease	0.84	disease	0.75	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.01	medium_impact	3.42	high_impact	0.25	0.8	57.11	8.64	0.68	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	COSM1138303	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15218	15218	A	C	MI.9329	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	472	158	T	P	Aca/Cca	-12.89	0	0.06	probably_damaging	0.99	neutral	0.23	neutral	3.05	neutral	-1.12	neutral	-1.53	low_impact	0.94	0.98	neutral	0.54	neutral	1.96	15.95	deleterious	0.07	0.35	NA	NA	0.83	disease	0.38	neutral	0.19	neutral	6	1	deleterious	0.12	neutral	-2	neutral	0.78	deleterious	-2.59	low_impact	-0.06	medium_impact	-0.34	medium_impact	0.37	0.8	18.16	18.64	0.39	N	0.99	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8963	8963	C	G	MI.933	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	437	146	T	S	aCc/aGc	8.69	1	0	probably_damaging	0.99	neutral	0.14	neutral	4.22	neutral	-1.13	deleterious	-3.66	medium_impact	2.23	0.75	neutral	0.54	neutral	3.46	23.00	deleterious	0.5	0.65	0.64	disease	0.55	disease	0.46	neutral	0.45	neutral	1	0.99	deleterious	0.08	neutral	1	deleterious	0.74	deleterious	-2.65	low_impact	-0.15	medium_impact	0.81	medium_impact	0.77	0.9	50	8.58	0.57	P	0.88	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15218	15218	A	T	MI.9330	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	472	158	T	S	Aca/Tca	-12.89	0	0.06	probably_damaging	0.95	neutral	0.43	neutral	3.11	neutral	-0.61	neutral	-0.29	low_impact	1.15	0.98	neutral	0.94	neutral	0.27	5.37	deleterious	0.4	0.5	NA	NA	0.48	neutral	0.25	neutral	0.19	neutral	6	0.95	neutral	0.24	neutral	-2	neutral	0.65	deleterious	-1.92	low_impact	0.16	medium_impact	-0.15	medium_impact	0.63	0.8	18.16	18.64	0.41	N	0.63	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15218	15218	A	G	MI.9331	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	472	158	T	A	Aca/Gca	-12.89	0	0.06	probably_damaging	0.95	neutral	0.53	neutral	3.04	neutral	-0.76	neutral	-1.61	medium_impact	2.65	0.97	neutral	0.75	neutral	1.50	13.34	neutral	0.31	0.45	NA	NA	0.6	disease	0.37	neutral	0.37	neutral	3	0.95	neutral	0.29	neutral	1	deleterious	0.66	deleterious	-1.92	low_impact	0.25	medium_impact	1.21	medium_impact	0.28	0.8	18.16	18.64	0.26	N	0.91	polymorphism	1	0.01	rs2853506	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15219	15219	C	T	MI.9332	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	473	158	T	M	aCa/aTa	1.1	0	0	probably_damaging	1	neutral	0.23	neutral	2.98	deleterious	-3.01	neutral	-2.09	medium_impact	2.75	0.91	neutral	0.55	neutral	3.89	23.50	deleterious	0.13	0.4	NA	NA	0.62	disease	0.32	neutral	0.35	neutral	3	1	deleterious	0.12	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	-0.06	medium_impact	1.3	medium_impact	0.43	0.8	18.16	18.64	0.41	N	0.98	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15219	15219	C	A	MI.9333	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	473	158	T	K	aCa/aAa	1.1	0	0	probably_damaging	0.99	neutral	0.31	neutral	3.07	neutral	-0.64	neutral	-1.15	low_impact	1.36	0.94	neutral	0.39	neutral	2.58	19.96	deleterious	0.11	0.4	NA	NA	0.8	disease	0.31	neutral	0.47	neutral	1	0.99	deleterious	0.16	neutral	-2	neutral	0.78	deleterious	-2.59	low_impact	0.03	medium_impact	0.04	medium_impact	0.43	0.8	18.16	18.64	0.33	N	0.96	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15221	15221	G	A	MI.9334	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	475	159	D	N	Gac/Aac	-11.51	0	0.01	benign	0.05	neutral	0.32	neutral	3.15	neutral	-0.53	neutral	0.33	low_impact	0.9	0.9	neutral	0.94	neutral	2.38	18.67	deleterious	0.56	0.6	0.41	neutral	0.53	disease	0.26	neutral	0.23	neutral	5	0.65	neutral	0.64	deleterious	-6	neutral	0.17	neutral	0.46	medium_impact	0.05	medium_impact	-0.38	medium_impact	0.71	0.85	11.58	18.84	0.44	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15221	15221	G	C	MI.9335	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	475	159	D	H	Gac/Cac	-11.51	0	0.01	probably_damaging	0.93	neutral	0.54	neutral	3.13	neutral	-1.21	neutral	-1.12	medium_impact	3.07	0.9	neutral	0.47	neutral	3.56	23.10	deleterious	0.1	0.4	0.45	neutral	0.63	disease	0.41	neutral	0.43	neutral	1	0.92	neutral	0.31	neutral	1	deleterious	0.66	deleterious	-1.78	low_impact	0.26	medium_impact	1.59	medium_impact	0.40	0.8	11.58	18.84	0.28	N	0.47	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15221	15221	G	T	MI.9336	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	475	159	D	Y	Gac/Tac	-11.51	0	0.01	probably_damaging	0.98	neutral	1	neutral	3.21	neutral	0.7	neutral	-1.53	medium_impact	2.46	0.91	neutral	0.61	neutral	3.81	23.40	deleterious	0.06	0.35	0.7	disease	0.84	disease	0.52	disease	0.7	disease	4	0.97	neutral	0.51	deleterious	1	deleterious	0.79	deleterious	-2.31	low_impact	1.85	high_impact	1.04	medium_impact	0.10	0.8	11.58	18.84	0.19	N	0.82	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15222	15222	A	C	MI.9337	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	476	159	D	A	gAc/gCc	-0.73	0	0	possibly_damaging	0.64	neutral	0.52	neutral	3.2	neutral	0.6	neutral	0.06	low_impact	1.21	0.91	neutral	0.66	neutral	2.28	18.00	deleterious	0.11	0.4	0.4	neutral	0.6	disease	0.48	neutral	0.21	neutral	6	0.61	neutral	0.44	neutral	-3	neutral	0.51	deleterious	-0.96	medium_impact	0.24	medium_impact	-0.1	medium_impact	0.26	0.8	11.58	18.84	0.31	N	0.24	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15222	15222	A	G	MI.9338	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	476	159	D	G	gAc/gGc	-0.73	0	0	possibly_damaging	0.52	neutral	0.35	neutral	3.17	neutral	-0.17	neutral	-1.04	medium_impact	2.63	0.84	neutral	0.52	neutral	3.76	23.40	deleterious	0.1	0.4	0.56	disease	0.67	disease	0.5	neutral	0.44	neutral	1	0.64	neutral	0.42	neutral	0	NA	0.40	neutral	-0.76	medium_impact	0.08	medium_impact	1.19	medium_impact	0.22	0.8	11.58	18.84	0.31	N	0.48	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15222	15222	A	T	MI.9339	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	476	159	D	V	gAc/gTc	-0.73	0	0	probably_damaging	0.9	neutral	0.51	neutral	3.16	neutral	-0.22	neutral	-0.48	medium_impact	2.9	0.9	neutral	0.7	neutral	2.53	19.64	deleterious	0.05	0.35	0.56	disease	0.79	disease	0.49	neutral	0.44	neutral	1	0.89	neutral	0.31	neutral	1	deleterious	0.70	deleterious	-1.62	low_impact	0.23	medium_impact	1.44	medium_impact	0.11	0.8	11.58	18.84	0.34	N	0.68	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8965	8965	A	T	MI.934	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	439	147	I	F	Atc/Ttc	-7.74	0	0	possibly_damaging	0.68	deleterious	0	neutral	3.85	deleterious	-3.23	deleterious	-3.55	medium_impact	2.86	0.82	neutral	0.42	neutral	3.90	23.50	deleterious	0.35	0.65	0.57	disease	0.73	disease	0.65	disease	0.66	disease	3	1	deleterious	0.16	neutral	4	deleterious	0.68	deleterious	-1.07	low_impact	-1.4	low_impact	1.35	medium_impact	0.75	0.9	46.46	7.68	0.32	N	0.97	polymorphism	0.66	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15223	15223	C	A	MI.9340	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	477	159	D	E	gaC/gaA	-0.04	0	0.06	possibly_damaging	0.52	neutral	0.3	neutral	3.19	neutral	0.45	neutral	-0.28	low_impact	1.25	0.91	neutral	0.67	neutral	2.85	21.60	deleterious	0.2	0.45	0.32	neutral	0.67	disease	0.26	neutral	0.24	neutral	5	0.68	neutral	0.39	neutral	-3	neutral	0.41	neutral	-0.76	medium_impact	0.02	medium_impact	-0.06	medium_impact	0.69	0.85	11.58	18.84	0.41	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15223	15223	C	G	MI.9341	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	477	159	D	E	gaC/gaG	-0.04	0	0.06	possibly_damaging	0.52	neutral	0.3	neutral	3.19	neutral	0.45	neutral	-0.28	low_impact	1.25	0.91	neutral	0.67	neutral	2.51	19.55	deleterious	0.2	0.45	0.32	neutral	0.67	disease	0.26	neutral	0.24	neutral	5	0.68	neutral	0.39	neutral	-3	neutral	0.41	neutral	-0.76	medium_impact	0.02	medium_impact	-0.06	medium_impact	0.69	0.85	11.58	18.84	0.41	N	0.27	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15224	15224	C	G	MI.9342	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	478	160	L	V	Cta/Gta	-6.47	0	0	probably_damaging	0.98	neutral	0.54	neutral	2.69	neutral	-2.47	neutral	-2.25	medium_impact	3.08	0.94	neutral	0.11	damaging	1.68	14.29	neutral	0.19	0.45	NA	NA	0.64	disease	0.32	neutral	0.4	neutral	2	0.97	neutral	0.28	neutral	1	deleterious	0.78	deleterious	-2.31	low_impact	0.26	medium_impact	1.6	medium_impact	0.53	0.8	18.16	10.11	0.2	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15224	15224	C	A	MI.9343	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	478	160	L	M	Cta/Ata	-6.47	0	0	probably_damaging	1	neutral	0.23	neutral	2.61	deleterious	-3.45	neutral	-1.52	medium_impact	2.56	0.95	neutral	0.2	damaging	3.70	23.30	deleterious	0.19	0.45	NA	NA	0.5	disease	0.3	neutral	0.33	neutral	3	1	deleterious	0.12	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	-0.06	medium_impact	1.13	medium_impact	0.59	0.8	18.16	10.11	0.39	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15225	15225	T	A	MI.9344	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	479	160	L	Q	cTa/cAa	-1.42	0	0	probably_damaging	1	neutral	0.31	neutral	2.57	deleterious	-6.25	deleterious	-4.79	high_impact	5.37	0.93	neutral	0.07	damaging	4.02	23.60	deleterious	0.01	0.35	NA	NA	0.75	disease	0.61	disease	0.65	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.03	medium_impact	3.68	high_impact	0.29	0.8	18.16	10.11	0.58	P	0.98	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15225	15225	T	C	MI.9345	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	479	160	L	P	cTa/cCa	-1.42	0	0	probably_damaging	1	neutral	0.22	neutral	2.57	deleterious	-6.27	deleterious	-5.59	high_impact	4.82	0.93	neutral	0.06	damaging	3.84	23.40	deleterious	0.01	0.35	NA	NA	0.81	disease	0.72	disease	0.7	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.08	medium_impact	3.18	high_impact	0.30	0.8	18.16	10.11	0.61	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15225	15225	T	G	MI.9346	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	479	160	L	R	cTa/cGa	-1.42	0	0	probably_damaging	1	neutral	0.34	neutral	2.58	deleterious	-5.87	deleterious	-4.81	high_impact	5.37	0.94	neutral	0.06	damaging	4.09	23.70	deleterious	0.01	0.35	NA	NA	0.87	disease	0.73	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.07	medium_impact	3.68	high_impact	0.16	0.8	18.16	10.11	0.66	P	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15227	15227	G	T	MI.9347	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	481	161	V	F	Gtt/Ttt	-2.8	0	0	probably_damaging	1	neutral	0.74	neutral	2.92	neutral	-2.98	deleterious	-4.08	high_impact	5.01	0.89	neutral	0.09	damaging	3.79	23.40	deleterious	0.02	0.35	0.82	disease	0.92	disease	0.7	disease	0.67	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.47	medium_impact	3.36	high_impact	0.38	0.8	58.95	8.56	0.63	P	0.98	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15227	15227	G	A	MI.9348	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	481	161	V	I	Gtt/Att	-2.8	0	0	probably_damaging	0.99	neutral	0.43	neutral	3.04	neutral	-0.81	neutral	-0.82	high_impact	4.17	0.91	neutral	0.11	damaging	1.90	15.60	deleterious	0.45	0.55	0.45	neutral	0.65	disease	0.58	disease	0.63	disease	3	0.99	deleterious	0.22	neutral	2	deleterious	0.63	deleterious	-2.59	low_impact	0.16	medium_impact	2.59	high_impact	0.91	0.95	58.95	8.56	0.33	N	0.34	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15227	15227	G	C	MI.9349	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	481	161	V	L	Gtt/Ctt	-2.8	0	0	probably_damaging	0.99	neutral	0.79	neutral	3	neutral	-1.45	neutral	-2.44	high_impact	4.28	0.93	neutral	0.08	damaging	1.78	14.87	neutral	0.12	0.4	0.52	disease	0.8	disease	0.56	disease	0.63	disease	3	0.99	deleterious	0.4	neutral	2	deleterious	0.80	deleterious	-2.59	low_impact	0.53	medium_impact	2.69	high_impact	0.45	0.8	58.95	8.56	0.24	N	0.69	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8965	8965	A	G	MI.935	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	439	147	I	V	Atc/Gtc	-7.74	0	0	benign	0.01	neutral	0.49	neutral	4.15	neutral	-0.82	neutral	-0.79	low_impact	1.72	0.95	neutral	0.68	neutral	2.02	16.36	deleterious	0.57	0.65	0.5	neutral	0.32	neutral	0.42	neutral	0.28	neutral	4	0.5	neutral	0.74	deleterious	-6	neutral	0.17	neutral	1.14	medium_impact	0.28	medium_impact	0.38	medium_impact	0.66	0.9	46.46	7.68	0.27	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15228	15228	T	A	MI.9350	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	482	161	V	D	gTt/gAt	5.92	1	0	probably_damaging	1	neutral	0.23	neutral	2.9	deleterious	-3.7	deleterious	-5.71	high_impact	5.57	0.89	neutral	0.09	damaging	4.57	24.40	deleterious	0.01	0.35	0.95	disease	0.88	disease	0.77	disease	0.63	disease	3	1	deleterious	0.12	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.06	medium_impact	3.86	high_impact	0.35	0.8	58.95	8.56	0.74	P	0.98	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15228	15228	T	C	MI.9351	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	482	161	V	A	gTt/gCt	5.92	1	0	probably_damaging	1	neutral	0.56	neutral	3.03	neutral	-0.84	deleterious	-3.25	high_impact	4.46	0.92	neutral	0.12	damaging	3.42	23.00	deleterious	0.05	0.35	0.76	disease	0.73	disease	0.65	disease	0.66	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.28	medium_impact	2.86	high_impact	0.16	0.8	58.95	8.56	0.53	P	0.62	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15228	15228	T	G	MI.9352	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	482	161	V	G	gTt/gGt	5.92	1	0	probably_damaging	1	neutral	0.44	neutral	2.91	deleterious	-3.51	deleterious	-5.71	high_impact	4.76	0.92	neutral	0.11	damaging	3.86	23.50	deleterious	0.01	0.35	0.92	disease	0.78	disease	0.7	disease	0.64	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.17	medium_impact	3.13	high_impact	0.32	0.8	58.95	8.56	0.72	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15230	15230	C	A	MI.9353	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	484	162	Q	K	Caa/Aaa	-5.55	0	0	probably_damaging	0.99	neutral	0.29	neutral	3.16	neutral	-0.15	neutral	-2.18	medium_impact	2.79	0.95	neutral	0.25	damaging	2.10	16.89	deleterious	0.2	0.45	0.23	neutral	0.91	disease	0.42	neutral	0.63	disease	3	0.99	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-2.59	low_impact	0.01	medium_impact	1.34	medium_impact	0.31	0.8	21.05	36.92	0.31	N	0.52	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15230	15230	C	G	MI.9354	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	484	162	Q	E	Caa/Gaa	-5.55	0	0	probably_damaging	0.98	neutral	0.28	neutral	3.2	neutral	0.37	neutral	-0.79	neutral_impact	0.42	0.97	neutral	0.91	neutral	-1.41	0.00	neutral	0.31	0.45	0.15	neutral	0.38	neutral	0.32	neutral	0.39	neutral	2	0.98	deleterious	0.15	neutral	-2	neutral	0.70	deleterious	-2.31	low_impact	0	medium_impact	-0.81	medium_impact	0.29	0.8	21.05	36.92	0.37	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15231	15231	A	C	MI.9355	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	485	162	Q	P	cAa/cCa	0.87	0.57	0	probably_damaging	0.99	neutral	0.2	neutral	3.13	neutral	-0.69	deleterious	-3.78	high_impact	4.04	0.9	neutral	0.13	damaging	1.74	14.66	neutral	0.02	0.35	0.51	disease	0.96	disease	0.7	disease	0.82	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-2.59	low_impact	-0.1	medium_impact	2.48	high_impact	0.15	0.8	21.05	36.92	0.37	N	0.92	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15231	15231	A	G	MI.9356	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	485	162	Q	R	cAa/cGa	0.87	0.57	0	probably_damaging	0.99	neutral	0.34	neutral	3.15	neutral	-0.32	neutral	-2.42	high_impact	3.6	0.91	neutral	0.17	damaging	1.70	14.39	neutral	0.18	0.45	0.31	neutral	0.93	disease	0.6	disease	0.67	disease	3	0.99	deleterious	0.18	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	0.07	medium_impact	2.08	high_impact	0.12	0.8	21.05	36.92	0.34	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15231	15231	A	T	MI.9357	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	485	162	Q	L	cAa/cTa	0.87	0.57	0	probably_damaging	0.99	neutral	0.65	neutral	3.09	neutral	-1.63	deleterious	-4.6	medium_impact	2.83	0.93	neutral	0.19	damaging	2.06	16.58	deleterious	0.05	0.35	0.22	neutral	0.95	disease	0.54	disease	0.74	disease	5	0.99	deleterious	0.33	neutral	1	deleterious	0.80	deleterious	-2.59	low_impact	0.37	medium_impact	1.38	medium_impact	0.08	0.8	21.05	36.92	0.23	N	0.85	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15232	15232	A	C	MI.9358	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	486	162	Q	H	caA/caC	4.31	0.99	0	probably_damaging	1	neutral	0.54	neutral	3.08	neutral	-2.17	deleterious	-2.79	medium_impact	3.4	0.89	neutral	0.2	damaging	3.18	22.70	deleterious	0.18	0.45	0.35	neutral	0.88	disease	0.57	disease	0.7	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.81	deleterious	-3.53	low_impact	0.26	medium_impact	1.89	medium_impact	0.43	0.8	21.05	36.92	0.41	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15232	15232	A	T	MI.9359	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	486	162	Q	H	caA/caT	4.31	0.99	0	probably_damaging	1	neutral	0.54	neutral	3.08	neutral	-2.17	deleterious	-2.79	medium_impact	3.4	0.89	neutral	0.2	damaging	3.22	22.70	deleterious	0.18	0.45	0.35	neutral	0.88	disease	0.57	disease	0.7	disease	4	1	deleterious	0.27	neutral	1	deleterious	0.81	deleterious	-3.53	low_impact	0.26	medium_impact	1.89	medium_impact	0.43	0.8	21.05	36.92	0.42	N	0.48	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8965	8965	A	C	MI.936	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	439	147	I	L	Atc/Ctc	-7.74	0	0	benign	0.09	neutral	0.25	neutral	4.04	neutral	-1.4	neutral	-1.75	low_impact	1.25	0.81	neutral	0.53	neutral	3.81	23.40	deleterious	0.42	0.65	0.49	neutral	0.54	disease	0.38	neutral	0.45	neutral	1	0.72	neutral	0.58	deleterious	-6	neutral	0.24	neutral	0.2	medium_impact	0.02	medium_impact	-0.03	medium_impact	0.69	0.9	46.46	7.68	0.33	N	0.68	polymorphism	0.99	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15233	15233	T	C	MI.9360	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	487	163	W	R	Tga/Cga	0.64	0.99	0	probably_damaging	1	neutral	0.43	neutral	3.02	deleterious	-3.4	deleterious	-11.41	high_impact	4.79	0.68	neutral	0.06	damaging	3.53	23.10	deleterious	0.01	0.35	0.89	disease	0.92	disease	0.82	disease	0.61	disease	2	1	deleterious	0.22	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.16	medium_impact	3.16	high_impact	0.12	0.8	57.89	8.62	0.58	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15233	15233	T	G	MI.9361	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	487	163	W	G	Tga/Gga	0.64	0.99	0	probably_damaging	1	neutral	0.43	neutral	3.03	neutral	-2.58	deleterious	-10.59	high_impact	5.25	0.8	neutral	0.13	damaging	3.65	23.20	deleterious	0.02	0.35	0.91	disease	0.85	disease	0.78	disease	0.63	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.16	medium_impact	3.57	high_impact	0.06	0.8	57.89	8.62	0.65	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15234	15234	G	T	MI.9362	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	488	163	W	L	tGa/tTa	5.69	1	0	probably_damaging	1	neutral	0.72	neutral	3.25	neutral	0.4	deleterious	-10.59	high_impact	4.31	0.8	neutral	0.08	damaging	4.00	23.60	deleterious	0.02	0.35	0.34	neutral	0.88	disease	0.75	disease	0.68	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.44	medium_impact	2.72	high_impact	0.10	0.8	57.89	8.62	0.5	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15234	15234	G	C	MI.9363	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	488	163	W	S	tGa/tCa	5.69	1	0	probably_damaging	1	neutral	0.56	neutral	3.04	neutral	-2.28	deleterious	-11.39	high_impact	4.79	0.79	neutral	0.1	damaging	3.83	23.40	deleterious	0.02	0.35	0.85	disease	0.92	disease	0.77	disease	0.63	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0.28	medium_impact	3.16	high_impact	0.05	0.8	57.89	8.62	0.65	P	0.99	disease_causing	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15235	15235	A	C	MI.9364	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	489	163	W	C	tgA/tgC	7.3	1	0.02	probably_damaging	1	neutral	0.18	neutral	3.02	deleterious	-3.77	deleterious	-10.6	high_impact	5.04	0.83	neutral	0.05	damaging	3.92	23.50	deleterious	0.02	0.35	0.9	disease	0.92	disease	0.77	disease	0.61	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.38	high_impact	0.10	0.8	57.89	8.62	0.65	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15235	15235	A	T	MI.9365	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	489	163	W	C	tgA/tgT	7.3	1	0.02	probably_damaging	1	neutral	0.18	neutral	3.02	deleterious	-3.77	deleterious	-10.6	high_impact	5.04	0.83	neutral	0.05	damaging	4.03	23.60	deleterious	0.02	0.35	0.9	disease	0.92	disease	0.77	disease	0.61	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.14	medium_impact	3.38	high_impact	0.10	0.8	57.89	8.62	0.66	P	1.00	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15236	15236	A	C	MI.9366	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	490	164	I	L	Atc/Ctc	1.33	0.99	0.04	benign	0.04	neutral	0.77	neutral	3.34	neutral	0.77	neutral	-1.23	low_impact	1.18	0.96	neutral	0.45	neutral	1.93	15.75	deleterious	0.25	0.45	0.16	neutral	0.61	disease	0.51	disease	0.22	neutral	6	0.16	neutral	0.87	deleterious	-6	neutral	0.11	neutral	0.56	medium_impact	0.51	medium_impact	-0.12	medium_impact	0.69	0.85	20	27.4	0.32	N	0.58	polymorphism	1	0.02	rs386829239	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15236	15236	A	T	MI.9367	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	490	164	I	F	Atc/Ttc	1.33	0.99	0.04	benign	0.29	neutral	0.75	neutral	3.02	neutral	-2.27	deleterious	-2.82	high_impact	3.65	0.95	neutral	0.42	neutral	2.22	17.67	deleterious	0.1	0.4	0.55	disease	0.83	disease	0.75	disease	0.74	disease	5	0.2	neutral	0.73	deleterious	-2	neutral	0.37	neutral	-0.37	medium_impact	0.48	medium_impact	2.12	high_impact	0.59	0.8	20	27.4	0.4	N	0.86	polymorphism	1	0.04	rs386829239	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15236	15236	A	G	MI.9368	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	490	164	I	V	Atc/Gtc	1.33	0.99	0.04	benign	0	neutral	0.62	neutral	3.18	neutral	-0.56	neutral	-0.43	low_impact	1.18	0.99	neutral	0.86	neutral	-0.02	2.41	deleterious	0.4	0.5	0.3	neutral	0.32	neutral	0.54	disease	0.41	neutral	2	0.38	neutral	0.81	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.34	medium_impact	-0.12	medium_impact	0.50	0.8	20	27.4	0.39	N	0.00	polymorphism	1	0.01	rs386829239	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15237	15237	T	A	MI.9369	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	491	164	I	N	aTc/aAc	0.87	0.99	0	possibly_damaging	0.88	neutral	0.48	neutral	2.93	deleterious	-4.9	deleterious	-4.79	high_impact	5.1	0.93	neutral	0.41	neutral	4.43	24.20	deleterious	0.05	0.35	0.73	disease	0.88	disease	0.74	disease	0.74	disease	5	0.87	neutral	0.3	neutral	1	deleterious	0.73	deleterious	-1.54	low_impact	0.2	medium_impact	3.44	high_impact	0.19	0.8	20	27.4	0.7	P	0.95	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8966	8966	T	A	MI.937	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	440	147	I	N	aTc/aAc	5.68	1	0	probably_damaging	0.91	deleterious	0	neutral	3.77	deleterious	-6.39	deleterious	-6.09	high_impact	4.13	0.83	neutral	0.38	neutral	4.46	24.20	deleterious	0.31	0.65	0.97	disease	0.74	disease	0.65	disease	0.81	disease	6	1	deleterious	0.05	neutral	6	deleterious	0.79	deleterious	-1.71	low_impact	-1.4	low_impact	2.44	high_impact	0.55	0.9	46.46	7.68	0.5	N	0.99	polymorphism	0.79	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15237	15237	T	C	MI.9370	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	491	164	I	T	aTc/aCc	0.87	0.99	0	benign	0.28	neutral	0.6	neutral	2.97	deleterious	-3.08	deleterious	-2.99	high_impact	4.75	0.97	neutral	0.45	neutral	3.06	22.40	deleterious	0.03	0.35	0.51	disease	0.77	disease	0.68	disease	0.56	disease	1	0.3	neutral	0.66	deleterious	-2	neutral	0.29	neutral	-0.35	medium_impact	0.32	medium_impact	3.12	high_impact	0.37	0.8	20	27.4	0.53	P	0.90	polymorphism	1	0.16	rs879217377	.	.	.	.	.	.	.	0.15	T15237C	Potentially functional variant cosegregating with LHON3635A	+	-	Reported	1	N	P	N,P	damaging
chrM	15237	15237	T	G	MI.9371	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	491	164	I	S	aTc/aGc	0.87	0.99	0	possibly_damaging	0.56	neutral	0.66	neutral	2.96	deleterious	-4.05	deleterious	-3.77	high_impact	4.75	0.94	neutral	0.39	neutral	3.98	23.60	deleterious	0.02	0.35	0.57	disease	0.86	disease	0.73	disease	0.74	disease	5	0.48	neutral	0.55	deleterious	1	deleterious	0.54	deleterious	-0.83	medium_impact	0.38	medium_impact	3.12	high_impact	0.19	0.8	20	27.4	0.61	P	0.88	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15238	15238	C	A	MI.9372	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	492	164	I	M	atC/atA	3.63	0.99	0	possibly_damaging	0.61	neutral	0.27	neutral	2.96	neutral	-2.23	neutral	-1.88	high_impact	3.68	0.91	neutral	0.42	neutral	3.36	22.90	deleterious	0.18	0.45	0.39	neutral	0.63	disease	0.57	disease	0.61	disease	2	0.74	neutral	0.33	neutral	1	deleterious	0.35	neutral	-0.91	medium_impact	-0.01	medium_impact	2.15	high_impact	0.60	0.8	20	27.4	0.54	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15238	15238	C	G	MI.9373	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	492	164	I	M	atC/atG	3.63	0.99	0	possibly_damaging	0.61	neutral	0.27	neutral	2.96	neutral	-2.23	neutral	-1.88	high_impact	3.68	0.91	neutral	0.42	neutral	3.00	22.20	deleterious	0.18	0.45	0.39	neutral	0.63	disease	0.57	disease	0.61	disease	2	0.74	neutral	0.33	neutral	1	deleterious	0.35	neutral	-0.91	medium_impact	-0.01	medium_impact	2.15	high_impact	0.60	0.8	20	27.4	0.54	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15239	15239	T	C	MI.9374	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	493	165	W	R	Tga/Cga	-2.11	0	0	probably_damaging	1	neutral	0.36	neutral	3.09	neutral	-2.13	deleterious	-11.44	high_impact	4.32	0.65	neutral	0.06	damaging	3.53	23.10	deleterious	0.02	0.35	0.68	disease	0.91	disease	0.84	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.09	medium_impact	2.73	high_impact	0.09	0.8	58.42	8.75	0.49	N	0.99	polymorphism	1	0.10	.	.	.	.	.	.	COSM1138304	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15239	15239	T	G	MI.9375	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	493	165	W	G	Tga/Gga	-2.11	0	0	probably_damaging	1	neutral	0.36	neutral	3.09	neutral	-2.2	deleterious	-10.63	high_impact	5.05	0.75	neutral	0.13	damaging	3.83	23.40	deleterious	0.02	0.35	0.76	disease	0.84	disease	0.82	disease	0.68	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.09	medium_impact	3.39	high_impact	0.04	0.8	58.42	8.75	0.66	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15240	15240	G	C	MI.9376	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	494	165	W	S	tGa/tCa	5.69	1	0	probably_damaging	1	neutral	0.42	neutral	3.12	neutral	-1.19	deleterious	-11.42	high_impact	4.63	0.85	neutral	0.11	damaging	3.95	23.60	deleterious	0.02	0.35	0.63	disease	0.92	disease	0.8	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.15	medium_impact	3.01	high_impact	0.05	0.8	58.42	8.75	0.63	P	0.99	disease_causing	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15240	15240	G	T	MI.9377	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	494	165	W	L	tGa/tTa	5.69	1	0	probably_damaging	1	neutral	0.67	neutral	3.32	neutral	1.36	deleterious	-10.62	high_impact	4.29	0.75	neutral	0.08	damaging	4.23	23.90	deleterious	0.03	0.35	0.44	neutral	0.86	disease	0.8	disease	0.68	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.39	medium_impact	2.7	high_impact	0.08	0.8	58.42	8.75	0.54	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15241	15241	A	C	MI.9378	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	495	165	W	C	tgA/tgC	7.07	1	0	probably_damaging	1	neutral	0.18	neutral	3.09	neutral	-2.03	deleterious	-10.64	high_impact	4.41	0.77	neutral	0.05	damaging	4.01	23.60	deleterious	0.02	0.35	0.59	disease	0.92	disease	0.83	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.14	medium_impact	2.81	high_impact	0.11	0.8	58.42	8.75	0.55	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15241	15241	A	T	MI.9379	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	495	165	W	C	tgA/tgT	7.07	1	0	probably_damaging	1	neutral	0.18	neutral	3.09	neutral	-2.03	deleterious	-10.64	high_impact	4.41	0.77	neutral	0.05	damaging	4.12	23.80	deleterious	0.02	0.35	0.59	disease	0.92	disease	0.83	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.14	medium_impact	2.81	high_impact	0.11	0.8	58.42	8.75	0.56	P	1.00	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8966	8966	T	C	MI.938	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	440	147	I	T	aTc/aCc	5.68	1	0	benign	0.39	neutral	0.08	neutral	3.82	deleterious	-3.87	deleterious	-4.08	medium_impact	2.25	0.88	neutral	0.62	neutral	3.40	23.00	deleterious	0.53	0.65	0.87	disease	0.49	neutral	0.49	neutral	0.61	disease	2	0.91	neutral	0.35	neutral	-3	neutral	0.55	deleterious	-0.57	medium_impact	-0.31	medium_impact	0.83	medium_impact	0.62	0.9	46.46	7.68	0.57	P	0.99	polymorphism	0.92	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15242	15242	G	T	MI.9380	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	496	166	G	W	Gga/Tga	4.77	1	0	probably_damaging	1	neutral	0.22	neutral	2.29	deleterious	-8.67	deleterious	-6.58	high_impact	5.63	0.84	neutral	0.05	damaging	4.50	24.30	deleterious	0.02	0.35	0.97	disease	0.91	disease	0.85	disease	0.67	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	-0.08	medium_impact	3.92	high_impact	0.07	0.8	58.16	8.83	0.64	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15242	15242	G	C	MI.9381	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	496	166	G	R	Gga/Cga	4.77	1	0	probably_damaging	1	neutral	0.35	neutral	2.33	deleterious	-5.52	deleterious	-6.56	high_impact	5.29	0.83	neutral	0.04	damaging	3.98	23.60	deleterious	0.03	0.35	0.86	disease	0.89	disease	0.86	disease	0.68	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.92	deleterious	-3.53	low_impact	0.08	medium_impact	3.61	high_impact	0.43	0.8	58.16	8.83	0.75	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15243	15243	G	T	MI.9382	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	497	166	G	V	gGa/gTa	9.13	1	0	probably_damaging	1	neutral	0.52	neutral	2.33	deleterious	-5.15	deleterious	-7.38	high_impact	5.29	0.84	neutral	0.07	damaging	3.77	23.40	deleterious	0.03	0.35	0.77	disease	0.9	disease	0.83	disease	0.73	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.24	medium_impact	3.61	high_impact	0.17	0.8	58.16	8.83	0.74	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15243	15243	G	A	MI.9383	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	497	166	G	E	gGa/gAa	9.13	1	0	probably_damaging	1	neutral	0.28	neutral	2.35	deleterious	-4.72	deleterious	-6.56	high_impact	5.29	0.82	neutral	0.05	damaging	3.89	23.50	deleterious	0.03	0.35	0.83	disease	0.89	disease	0.87	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	0	medium_impact	3.61	high_impact	0.22	0.8	58.16	8.83	0.82	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	G15243A	HCM	-	+	Reported	3	.	P	P	damaging
chrM	15243	15243	G	C	MI.9384	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	497	166	G	A	gGa/gCa	9.13	1	0	probably_damaging	1	neutral	0.52	neutral	2.39	deleterious	-3.73	deleterious	-4.91	high_impact	5.29	0.84	neutral	0.1	damaging	3.09	22.50	deleterious	0.03	0.35	0.6	disease	0.8	disease	0.82	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.24	medium_impact	3.61	high_impact	0.28	0.8	58.16	8.83	0.77	P	0.83	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15245	15245	G	A	MI.9385	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	499	167	G	S	Ggc/Agc	-20	0	0	probably_damaging	1	neutral	0.43	neutral	2.94	neutral	-2.7	deleterious	-4.91	high_impact	4.08	0.79	neutral	0.35	neutral	4.14	23.80	deleterious	0.03	0.35	0.72	disease	0.82	disease	0.61	disease	0.65	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.16	medium_impact	2.51	high_impact	0.64	0.8	56.05	8.33	0.28	N	1.00	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15245	15245	G	C	MI.9386	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	499	167	G	R	Ggc/Cgc	-20	0	0	probably_damaging	1	neutral	0.35	neutral	2.86	deleterious	-4.08	deleterious	-6.56	high_impact	5.59	0.79	neutral	0.22	damaging	3.97	23.60	deleterious	0.02	0.35	0.9	disease	0.86	disease	0.82	disease	0.63	disease	3	1	deleterious	0.18	neutral	2	deleterious	0.91	deleterious	-3.53	low_impact	0.08	medium_impact	3.88	high_impact	0.55	0.8	56.05	8.33	0.67	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15245	15245	G	T	MI.9387	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	499	167	G	C	Ggc/Tgc	-20	0	0	probably_damaging	1	neutral	0.17	neutral	2.8	deleterious	-6.87	deleterious	-7.4	high_impact	5.25	0.79	neutral	0.22	damaging	4.20	23.90	deleterious	0.02	0.35	0.92	disease	0.89	disease	0.72	disease	0.6	disease	2	1	deleterious	0.09	neutral	2	deleterious	0.90	deleterious	-3.53	low_impact	-0.15	medium_impact	3.57	high_impact	0.23	0.8	56.05	8.33	0.55	N	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15246	15246	G	C	MI.9388	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	500	167	G	A	gGc/gCc	7.07	1	0	probably_damaging	1	neutral	0.51	neutral	2.87	deleterious	-3.83	deleterious	-4.91	high_impact	4.9	0.89	neutral	0.44	neutral	3.04	22.40	deleterious	0.04	0.35	0.7	disease	0.74	disease	0.7	disease	0.68	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.23	medium_impact	3.26	high_impact	0.42	0.8	56.05	8.33	0.72	P	0.83	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15246	15246	G	A	MI.9389	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	500	167	G	D	gGc/gAc	7.07	1	0	probably_damaging	1	neutral	0.2	neutral	2.9	neutral	-2.51	deleterious	-5.74	high_impact	3.54	0.72	neutral	0.28	damaging	3.82	23.40	deleterious	0.02	0.35	0.88	disease	0.86	disease	0.8	disease	0.64	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.1	medium_impact	2.02	high_impact	0.15	0.8	56.05	8.33	0.6	P	1.00	polymorphism	1	0.10	rs1057516075	Likely_pathogenic	Macrocephaly|Hearing_impairment|Developmental_delay	354295	Human_Phenotype_Ontology:HP:0000256,MedGen:C2243051,OMIM:248000|Human_Phenotype_Ontology:HP:0000365,MedGen:C0018772|MedGen:C0424605	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	8966	8966	T	G	MI.939	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	440	147	I	S	aTc/aGc	5.68	1	0	possibly_damaging	0.68	deleterious	0	neutral	3.79	deleterious	-5.23	deleterious	-5.13	high_impact	3.79	0.82	neutral	0.44	neutral	4.32	24.00	deleterious	0.29	0.65	0.94	disease	0.79	disease	0.64	disease	0.81	disease	6	1	deleterious	0.16	neutral	5	deleterious	0.65	deleterious	-1.07	low_impact	-1.4	low_impact	2.15	high_impact	0.54	0.9	46.46	7.68	0.51	P	0.95	polymorphism	0.75	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15246	15246	G	T	MI.9390	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	500	167	G	V	gGc/gTc	7.07	1	0	probably_damaging	1	neutral	0.52	neutral	2.83	deleterious	-6.12	deleterious	-7.38	high_impact	5.59	0.79	neutral	0.36	neutral	3.75	23.30	deleterious	0.02	0.35	0.83	disease	0.86	disease	0.74	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.24	medium_impact	3.88	high_impact	0.14	0.8	56.05	8.33	0.71	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15248	15248	T	A	MI.9391	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	502	168	Y	N	Tac/Aac	-15.18	0	0	probably_damaging	1	neutral	0.32	neutral	3.17	neutral	-1.07	deleterious	-5.12	medium_impact	2.39	0.92	neutral	0.61	neutral	3.92	23.50	deleterious	0.07	0.35	0.86	disease	0.8	disease	0.66	disease	0.72	disease	4	1	deleterious	0.16	neutral	1	deleterious	0.86	deleterious	-3.53	low_impact	0.05	medium_impact	0.98	medium_impact	0.14	0.8	21.58	50.18	0.34	N	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15248	15248	T	G	MI.9392	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	502	168	Y	D	Tac/Gac	-15.18	0	0	probably_damaging	1	neutral	0.22	neutral	3.2	neutral	-0.9	deleterious	-5.19	medium_impact	2.04	0.9	neutral	0.43	neutral	3.85	23.40	deleterious	0.03	0.35	0.93	disease	0.79	disease	0.75	disease	0.71	disease	4	1	deleterious	0.11	neutral	1	deleterious	0.88	deleterious	-3.53	low_impact	-0.08	medium_impact	0.66	medium_impact	0.12	0.8	21.58	50.18	0.37	N	0.94	disease_causing	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15248	15248	T	C	MI.9393	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	502	168	Y	H	Tac/Cac	-15.18	0	0	probably_damaging	1	neutral	0.54	neutral	3.1	neutral	-1.68	deleterious	-3.34	low_impact	1.64	0.92	neutral	0.47	neutral	3.42	23.00	deleterious	0.13	0.4	0.73	disease	0.53	disease	0.74	disease	0.71	disease	4	1	deleterious	0.27	neutral	-2	neutral	0.81	deleterious	-3.53	low_impact	0.26	medium_impact	0.3	medium_impact	0.25	0.8	21.58	50.18	0.28	N	0.79	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15249	15249	A	T	MI.9394	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	503	168	Y	F	tAc/tTc	4.54	1	0	probably_damaging	1	neutral	0.76	neutral	3.17	neutral	1.79	neutral	1.96	neutral_impact	-2.82	0.96	neutral	0.91	neutral	-0.86	0.03	neutral	0.3	0.45	0.19	neutral	0.1	neutral	0.19	neutral	0.27	neutral	5	1	deleterious	0.38	neutral	-2	neutral	0.66	deleterious	-3.53	low_impact	0.49	medium_impact	-3.75	low_impact	0.47	0.8	21.58	50.18	0.48	N	0.07	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15249	15249	A	G	MI.9395	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	503	168	Y	C	tAc/tGc	4.54	1	0	probably_damaging	1	neutral	0.18	neutral	3.08	neutral	-2.79	deleterious	-4.38	medium_impact	2.19	0.95	neutral	0.42	neutral	3.47	23.00	deleterious	0.03	0.35	0.94	disease	0.78	disease	0.69	disease	0.72	disease	4	1	deleterious	0.09	neutral	1	deleterious	0.87	deleterious	-3.53	low_impact	-0.14	medium_impact	0.8	medium_impact	0.09	0.8	21.58	50.18	0.45	N	0.81	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15249	15249	A	C	MI.9396	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	503	168	Y	S	tAc/tCc	4.54	1	0	probably_damaging	1	neutral	0.44	neutral	3.18	neutral	-0.61	deleterious	-4.35	medium_impact	2.04	0.95	neutral	0.58	neutral	3.51	23.10	deleterious	0.05	0.35	0.85	disease	0.66	disease	0.65	disease	0.67	disease	3	1	deleterious	0.22	neutral	1	deleterious	0.86	deleterious	-3.53	low_impact	0.17	medium_impact	0.66	medium_impact	0.22	0.8	21.58	50.18	0.49	N	0.84	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15251	15251	T	G	MI.9397	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	505	169	S	A	Tca/Gca	-4.4	0	0	benign	0.07	neutral	0.52	neutral	3.18	neutral	-0.9	neutral	-1.78	low_impact	1.88	0.95	neutral	0.23	damaging	0.76	9.18	deleterious	0.15	0.4	0.41	neutral	0.51	disease	0.36	neutral	0.21	neutral	6	0.42	neutral	0.73	deleterious	-6	neutral	0.21	neutral	0.32	medium_impact	0.24	medium_impact	0.51	medium_impact	0.44	0.8	17.63	16.71	0.26	N	0.11	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15251	15251	T	A	MI.9398	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	505	169	S	T	Tca/Aca	-4.4	0	0	benign	0.07	neutral	0.46	neutral	3.19	neutral	-1.52	neutral	-2.23	high_impact	3.69	0.97	neutral	0.15	damaging	2.04	16.45	deleterious	0.17	0.45	0.35	neutral	0.69	disease	0.59	disease	0.63	disease	3	0.48	neutral	0.7	deleterious	-2	neutral	0.22	neutral	0.32	medium_impact	0.18	medium_impact	2.16	high_impact	0.50	0.8	17.63	16.71	0.33	N	0.66	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15251	15251	T	C	MI.9399	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	505	169	S	P	Tca/Cca	-4.4	0	0	benign	0.01	neutral	0.23	neutral	3.06	deleterious	-3.12	deleterious	-3.78	high_impact	4.88	0.94	neutral	0.08	damaging	2.36	18.59	deleterious	0.06	0.35	0.76	disease	0.84	disease	0.61	disease	0.66	disease	3	0.77	neutral	0.61	deleterious	-2	neutral	0.31	neutral	1.13	medium_impact	-0.06	medium_impact	3.24	high_impact	0.20	0.8	17.63	16.71	0.57	P	0.93	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8568	8568	C	A	MI.94	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	42	14	I	M	atC/atA	1.75	0.01	0	possibly_damaging	0.82	neutral	0.26	neutral	4.59	neutral	-1.38	neutral	-0.03	neutral_impact	0.62	0.91	neutral	0.9	neutral	4.37	24.10	deleterious	0.62	0.7	0.37	neutral	0.21	neutral	0.32	neutral	0.36	neutral	3	0.87	neutral	0.22	neutral	-3	neutral	0.53	deleterious	-1.38	low_impact	0.04	medium_impact	-0.57	medium_impact	0.83	0.9	13.72	12.42	0.54	P	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8967	8967	C	A	MI.940	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	441	147	I	M	atC/atA	4.76	1	0	possibly_damaging	0.82	neutral	0.05	neutral	3.8	deleterious	-4.42	deleterious	-2.6	medium_impact	2.66	0.91	neutral	0.51	neutral	3.77	23.40	deleterious	0.48	0.65	0.84	disease	0.51	disease	0.56	disease	0.6	disease	2	0.97	neutral	0.12	neutral	0	NA	0.70	deleterious	-1.38	low_impact	-0.43	medium_impact	1.18	medium_impact	0.86	0.9	46.46	7.68	0.53	P	0.80	polymorphism	0.97	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15252	15252	C	G	MI.9400	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	506	169	S	W	tCa/tGa	4.54	1	0	probably_damaging	0.96	neutral	0.27	neutral	3.05	deleterious	-3.91	deleterious	-5.42	high_impact	5.42	0.96	neutral	0.09	damaging	4.31	24.00	deleterious	0.06	0.35	0.94	disease	0.9	disease	0.75	disease	0.64	disease	3	0.97	neutral	0.16	neutral	2	deleterious	0.84	deleterious	-2.02	low_impact	-0.01	medium_impact	3.73	high_impact	0.16	0.8	17.63	16.71	0.69	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15252	15252	C	T	MI.9401	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	506	169	S	L	tCa/tTa	4.54	1	0	benign	0.41	neutral	0.74	neutral	3.14	neutral	-1.03	deleterious	-4.47	high_impact	4.28	0.95	neutral	0.06	damaging	4.32	24.00	deleterious	0.05	0.35	0.68	disease	0.86	disease	0.68	disease	0.7	disease	4	0.31	neutral	0.67	deleterious	-2	neutral	0.59	deleterious	-0.58	medium_impact	0.47	medium_impact	2.69	high_impact	0.55	0.8	17.63	16.71	0.43	N	0.93	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15254	15254	G	T	MI.9402	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	508	170	V	L	Gta/Tta	-3.03	0	0	probably_damaging	0.98	neutral	0.68	neutral	3.08	neutral	-1.45	neutral	-2.29	high_impact	4.38	0.91	neutral	0.42	neutral	1.88	15.48	deleterious	0.12	0.4	0.52	disease	0.77	disease	0.73	disease	0.69	disease	4	0.98	neutral	0.35	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0.4	medium_impact	2.78	high_impact	0.32	0.8	20.53	43.28	0.36	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15254	15254	G	A	MI.9403	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	508	170	V	M	Gta/Ata	-3.03	0	0	probably_damaging	1	neutral	0.22	neutral	2.97	deleterious	-3.41	neutral	-2.38	high_impact	5.49	0.84	neutral	0.43	neutral	3.63	23.20	deleterious	0.1	0.4	0.43	neutral	0.74	disease	0.76	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	-0.08	medium_impact	3.79	high_impact	0.58	0.8	20.53	43.28	0.71	P	0.84	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15254	15254	G	C	MI.9404	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	508	170	V	L	Gta/Cta	-3.03	0	0	probably_damaging	0.98	neutral	0.68	neutral	3.08	neutral	-1.45	neutral	-2.29	high_impact	4.38	0.91	neutral	0.42	neutral	1.77	14.83	neutral	0.12	0.4	0.52	disease	0.77	disease	0.73	disease	0.69	disease	4	0.98	neutral	0.35	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0.4	medium_impact	2.78	high_impact	0.32	0.8	20.53	43.28	0.36	N	0.70	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15255	15255	T	A	MI.9405	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	509	170	V	E	gTa/gAa	7.3	1	0	probably_damaging	1	neutral	0.27	neutral	2.97	deleterious	-4.4	deleterious	-4.92	high_impact	5.49	0.89	neutral	0.42	neutral	4.75	24.70	deleterious	0.02	0.35	0.93	disease	0.88	disease	0.84	disease	0.7	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.01	medium_impact	3.79	high_impact	0.24	0.8	20.53	43.28	0.81	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15255	15255	T	C	MI.9406	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	509	170	V	A	gTa/gCa	7.3	1	0	probably_damaging	1	neutral	0.56	neutral	3.04	neutral	-2.56	deleterious	-3.26	high_impact	4.59	0.91	neutral	0.51	neutral	3.34	22.90	deleterious	0.06	0.35	0.76	disease	0.73	disease	0.76	disease	0.69	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.28	medium_impact	2.97	high_impact	0.22	0.8	20.53	43.28	0.63	P	0.83	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15255	15255	T	G	MI.9407	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	509	170	V	G	gTa/gGa	7.3	1	0	probably_damaging	1	neutral	0.4	neutral	2.98	deleterious	-3.22	deleterious	-5.74	high_impact	4.79	0.9	neutral	0.48	neutral	3.72	23.30	deleterious	0.02	0.35	0.92	disease	0.8	disease	0.77	disease	0.67	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.13	medium_impact	3.16	high_impact	0.24	0.8	20.53	43.28	0.74	P	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15257	15257	G	T	MI.9408	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	511	171	D	Y	Gac/Tac	-4.4	0	0.03	possibly_damaging	0.88	neutral	1	neutral	3.1	deleterious	-3.59	deleterious	-6.97	high_impact	4.7	0.91	neutral	0.43	neutral	3.85	23.40	deleterious	0.03	0.35	0.75	disease	0.94	disease	0.79	disease	0.79	disease	6	0.88	neutral	0.56	deleterious	1	deleterious	0.83	deleterious	-1.54	low_impact	1.85	high_impact	3.07	high_impact	0.12	0.8	19.74	12.46	0.53	P	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15257	15257	G	A	MI.9409	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	511	171	D	N	Gac/Aac	-4.4	0	0.03	benign	0.01	neutral	0.35	neutral	3.2	neutral	-0.15	deleterious	-3.57	medium_impact	2	0.49	damaging	0.53	neutral	3.86	23.50	deleterious	0.32	0.5	0.34	neutral	0.84	disease	0.6	disease	0.38	neutral	2	0.64	neutral	0.67	deleterious	-3	neutral	0.24	neutral	1.13	medium_impact	0.08	medium_impact	0.62	medium_impact	0.76	0.85	19.74	12.46	0.43	N	0.25	polymorphism	1	0.04	rs41518645	Conflicting_interpretations_of_pathogenicity	Leber's_optic_atrophy	24713	Human_Phenotype_Ontology:HP:0001112,MedGen:C0917796,OMIM:535000,Orphanet:ORPHA104,SNOMED_CT:58610003	.	COSM1138306	.	.	G15257A	LHON	+	-	Conflicting reports / J2 marker	44	N	N	N	damaging
chrM	8967	8967	C	G	MI.941	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	441	147	I	M	atC/atG	4.76	1	0	possibly_damaging	0.82	neutral	0.05	neutral	3.8	deleterious	-4.42	deleterious	-2.6	medium_impact	2.66	0.91	neutral	0.51	neutral	3.34	22.90	deleterious	0.48	0.65	0.84	disease	0.51	disease	0.56	disease	0.6	disease	2	0.97	neutral	0.12	neutral	0	NA	0.70	deleterious	-1.38	low_impact	-0.43	medium_impact	1.18	medium_impact	0.86	0.9	46.46	7.68	0.53	N	0.80	polymorphism	0.97	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15257	15257	G	C	MI.9410	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	511	171	D	H	Gac/Cac	-4.4	0	0.03	possibly_damaging	0.69	neutral	0.55	neutral	3.12	neutral	-2.66	deleterious	-5.31	high_impact	4.28	0.87	neutral	0.35	neutral	3.53	23.10	deleterious	0.05	0.35	0.64	disease	0.87	disease	0.76	disease	0.73	disease	5	0.65	neutral	0.43	neutral	1	deleterious	0.64	deleterious	-1.06	low_impact	0.27	medium_impact	2.69	high_impact	0.43	0.8	19.74	12.46	0.38	N	0.89	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15258	15258	A	C	MI.9411	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	512	171	D	A	gAc/gCc	5.92	1	0	benign	0.11	neutral	0.58	neutral	3.21	neutral	-1.63	deleterious	-6.13	high_impact	4.35	0.91	neutral	0.46	neutral	3.32	22.90	deleterious	0.04	0.35	0.44	neutral	0.87	disease	0.76	disease	0.72	disease	4	0.33	neutral	0.74	deleterious	-2	neutral	0.31	neutral	0.12	medium_impact	0.3	medium_impact	2.76	high_impact	0.35	0.8	19.74	12.46	0.6	P	0.84	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15258	15258	A	G	MI.9412	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	512	171	D	G	gAc/gGc	5.92	1	0	benign	0.01	neutral	0.38	neutral	3.31	neutral	-0.07	deleterious	-5.24	medium_impact	2.74	0.82	neutral	0.54	neutral	3.74	23.30	deleterious	0.05	0.35	0.58	disease	0.84	disease	0.75	disease	0.6	disease	2	0.61	neutral	0.69	deleterious	-3	neutral	0.26	neutral	1.13	medium_impact	0.11	medium_impact	1.29	medium_impact	0.28	0.8	19.74	12.46	0.54	P	0.80	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15258	15258	A	T	MI.9413	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	512	171	D	V	gAc/gTc	5.92	1	0	possibly_damaging	0.51	neutral	0.55	neutral	3.11	deleterious	-3.95	deleterious	-7.01	high_impact	4.9	0.91	neutral	0.48	neutral	3.64	23.20	deleterious	0.02	0.35	0.64	disease	0.92	disease	0.77	disease	0.74	disease	5	0.47	neutral	0.52	deleterious	1	deleterious	0.62	deleterious	-0.75	medium_impact	0.27	medium_impact	3.26	high_impact	0.10	0.8	19.74	12.46	0.65	P	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15259	15259	C	A	MI.9414	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	513	171	D	E	gaC/gaA	5.46	1	0	benign	0.04	neutral	0.35	neutral	3.19	neutral	-1.12	deleterious	-3.07	high_impact	4.04	0.89	neutral	0.43	neutral	2.39	18.74	deleterious	0.17	0.45	0.29	neutral	0.81	disease	0.67	disease	0.67	disease	3	0.62	neutral	0.66	deleterious	-2	neutral	0.23	neutral	0.56	medium_impact	0.08	medium_impact	2.48	high_impact	0.45	0.8	19.74	12.46	0.62	P	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15259	15259	C	G	MI.9415	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	513	171	D	E	gaC/gaG	5.46	1	0	benign	0.04	neutral	0.35	neutral	3.19	neutral	-1.12	deleterious	-3.07	high_impact	4.04	0.89	neutral	0.43	neutral	2.07	16.65	deleterious	0.17	0.45	0.29	neutral	0.81	disease	0.67	disease	0.67	disease	3	0.62	neutral	0.66	deleterious	-2	neutral	0.23	neutral	0.56	medium_impact	0.08	medium_impact	2.48	high_impact	0.45	0.8	19.74	12.46	0.62	P	0.85	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15260	15260	A	C	MI.9416	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	514	172	S	R	Agt/Cgt	-0.5	0.13	0	benign	0.36	neutral	0.35	neutral	3.1	neutral	-1.32	neutral	-0.54	medium_impact	2.27	0.95	neutral	0.53	neutral	3.36	22.90	deleterious	0.14	0.4	0.31	neutral	0.85	disease	0.63	disease	0.77	disease	5	0.58	neutral	0.5	deleterious	-3	neutral	0.45	deleterious	-0.5	medium_impact	0.08	medium_impact	0.87	medium_impact	0.40	0.8	21.32	51.81	0.35	N	0.46	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15260	15260	A	T	MI.9417	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	514	172	S	C	Agt/Tgt	-0.5	0.13	0	probably_damaging	0.92	neutral	0.18	neutral	3.04	deleterious	-4.39	deleterious	-3.17	low_impact	1.92	0.95	neutral	0.44	neutral	3.21	22.70	deleterious	0.1	0.4	0.78	disease	0.78	disease	0.51	disease	0.61	disease	2	0.96	neutral	0.13	neutral	-2	neutral	0.76	deleterious	-1.72	low_impact	-0.14	medium_impact	0.55	medium_impact	0.28	0.8	21.32	51.81	0.41	N	0.73	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15260	15260	A	G	MI.9418	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	514	172	S	G	Agt/Ggt	-0.5	0.13	0	benign	0.17	neutral	0.34	neutral	3.12	neutral	-0.23	neutral	-1.19	neutral_impact	0.22	0.94	neutral	0.58	neutral	1.78	14.84	neutral	0.22	0.45	0.31	neutral	0.52	disease	0.38	neutral	0.45	neutral	1	0.6	neutral	0.59	deleterious	-6	neutral	0.25	neutral	-0.09	medium_impact	0.07	medium_impact	-0.99	medium_impact	0.51	0.8	21.32	51.81	0.37	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15261	15261	G	A	MI.9419	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	515	172	S	N	aGt/aAt	5.46	1	0	benign	0.01	neutral	0.33	neutral	3.19	neutral	1.2	neutral	2.69	neutral_impact	-3	0.92	neutral	0.8	neutral	1.23	11.89	neutral	0.52	0.6	0.17	neutral	0.14	neutral	0.16	neutral	0.24	neutral	5	0.66	neutral	0.66	deleterious	-6	neutral	0.09	neutral	1.13	medium_impact	0.06	medium_impact	-3.92	low_impact	0.40	0.8	21.32	51.81	0.57	P	0.43	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8968	8968	A	T	MI.942	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	442	148	S	C	Agc/Tgc	-5.89	0	0	probably_damaging	1	deleterious	0	neutral	3.39	deleterious	-6.63	deleterious	-4.62	high_impact	4.59	0.45	damaging	0.04	damaging	3.40	23.00	deleterious	0.21	0.65	0.97	disease	0.73	disease	0.68	disease	0.79	disease	6	1	deleterious	0	neutral	6	deleterious	0.82	deleterious	-3.6	low_impact	-1.4	low_impact	2.84	high_impact	0.55	0.9	50	8.78	0.38	N	0.99	polymorphism	0.74	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15261	15261	G	T	MI.9420	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	515	172	S	I	aGt/aTt	5.46	1	0	possibly_damaging	0.72	neutral	0.4	neutral	3.07	deleterious	-3.68	deleterious	-3.21	low_impact	1.72	0.95	neutral	0.57	neutral	3.94	23.50	deleterious	0.11	0.4	0.56	disease	0.78	disease	0.52	disease	0.65	disease	3	0.73	neutral	0.34	neutral	-3	neutral	0.68	deleterious	-1.11	low_impact	0.13	medium_impact	0.37	medium_impact	0.42	0.8	21.32	51.81	0.48	N	0.87	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15261	15261	G	C	MI.9421	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	515	172	S	T	aGt/aCt	5.46	1	0	benign	0.25	neutral	0.4	neutral	3.17	neutral	-0.6	neutral	-0.94	low_impact	1.07	0.94	neutral	0.63	neutral	1.84	15.24	deleterious	0.29	0.45	0.32	neutral	0.4	neutral	0.51	disease	0.43	neutral	1	0.52	neutral	0.58	deleterious	-6	neutral	0.28	neutral	-0.29	medium_impact	0.13	medium_impact	-0.22	medium_impact	0.52	0.8	21.32	51.81	0.56	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15263	15263	C	G	MI.9422	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	517	173	P	A	Ccc/Gcc	-0.04	0.91	0	benign	0	neutral	0.82	neutral	3.35	neutral	1.21	neutral	1.54	neutral_impact	-1.28	0.96	neutral	0.92	neutral	0.06	3.23	deleterious	0.14	0.4	0.15	neutral	0.12	neutral	0.29	neutral	0.24	neutral	5	0.17	neutral	0.91	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.58	medium_impact	-2.36	low_impact	0.67	0.85	21.84	44	0.3	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15263	15263	C	A	MI.9423	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	517	173	P	T	Ccc/Acc	-0.04	0.91	0	benign	0.28	neutral	0.61	neutral	3.19	neutral	-0.85	neutral	-0.94	medium_impact	3.5	0.92	neutral	0.6	neutral	3.61	23.20	deleterious	0.13	0.4	0.5	neutral	0.42	neutral	0.55	disease	0.35	neutral	3	0.29	neutral	0.67	deleterious	-3	neutral	0.35	neutral	-0.35	medium_impact	0.33	medium_impact	1.98	medium_impact	0.67	0.85	21.84	44	0.28	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15263	15263	C	T	MI.9424	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	517	173	P	S	Ccc/Tcc	-0.04	0.91	0	benign	0.28	neutral	0.76	neutral	3.22	neutral	0.09	neutral	-0.31	medium_impact	2.07	0.92	neutral	0.61	neutral	3.86	23.50	deleterious	0.18	0.45	0.48	neutral	0.52	disease	0.53	disease	0.58	disease	2	0.19	neutral	0.74	deleterious	-3	neutral	0.38	neutral	-0.35	medium_impact	0.49	medium_impact	0.69	medium_impact	0.22	0.8	21.84	44	0.24	N	0.46	polymorphism	1	0.01	rs200455825	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15264	15264	C	T	MI.9425	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	518	173	P	L	cCc/cTc	4.77	1	0	possibly_damaging	0.5	neutral	0.39	neutral	3.22	neutral	-0.72	neutral	-1.98	medium_impact	2.9	0.93	neutral	0.53	neutral	4.37	24.10	deleterious	0.1	0.4	0.45	neutral	0.61	disease	0.63	disease	0.69	disease	4	0.59	neutral	0.45	neutral	0	NA	0.52	deleterious	-0.73	medium_impact	0.12	medium_impact	1.44	medium_impact	0.57	0.8	21.84	44	0.54	N	0.84	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15264	15264	C	G	MI.9426	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	518	173	P	R	cCc/cGc	4.77	1	0	possibly_damaging	0.84	neutral	0.55	neutral	3.22	neutral	-0.92	neutral	-1.77	medium_impact	3.5	0.93	neutral	0.48	neutral	3.58	23.20	deleterious	0.07	0.35	0.65	disease	0.8	disease	0.79	disease	0.69	disease	4	0.82	neutral	0.36	neutral	0	NA	0.72	deleterious	-1.4	low_impact	0.27	medium_impact	1.98	medium_impact	0.28	0.8	21.84	44	0.48	N	0.78	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15264	15264	C	A	MI.9427	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	518	173	P	H	cCc/cAc	4.77	1	0	probably_damaging	0.96	neutral	0.2	neutral	3.16	neutral	-1.66	neutral	-2.39	high_impact	4.04	0.88	neutral	0.46	neutral	3.95	23.60	deleterious	0.07	0.35	0.76	disease	0.55	disease	0.76	disease	0.7	disease	4	0.97	neutral	0.12	neutral	2	deleterious	0.75	deleterious	-2.02	low_impact	-0.1	medium_impact	2.48	high_impact	0.27	0.8	21.84	44	0.57	P	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15266	15266	A	T	MI.9428	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	520	174	T	S	Acc/Tcc	-14.5	0	0	probably_damaging	0.99	neutral	0.69	neutral	2.83	deleterious	-3.15	deleterious	-3.27	high_impact	4.74	0.84	neutral	0.47	neutral	2.27	17.99	deleterious	0.22	0.45	0.64	disease	0.71	disease	0.68	disease	0.65	disease	3	0.99	deleterious	0.35	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.41	medium_impact	3.11	high_impact	0.39	0.8	57.63	8.75	0.6	P	0.81	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15266	15266	A	C	MI.9429	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	520	174	T	P	Acc/Ccc	-14.5	0	0	probably_damaging	1	neutral	0.35	neutral	2.8	deleterious	-4.66	deleterious	-4.93	high_impact	5.29	0.92	neutral	0.33	neutral	3.90	23.50	deleterious	0.03	0.35	0.83	disease	0.79	disease	0.85	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.08	medium_impact	3.61	high_impact	0.29	0.8	57.63	8.75	0.73	P	0.95	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8968	8968	A	G	MI.943	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	442	148	S	G	Agc/Ggc	-5.89	0	0	probably_damaging	0.98	deleterious	0.01	neutral	3.52	neutral	-2.12	deleterious	-3.67	medium_impact	3.15	0.52	damaging	0.14	damaging	3.61	23.20	deleterious	0.3	0.65	0.6	disease	0.66	disease	0.66	disease	0.66	disease	3	1	deleterious	0.02	neutral	5	deleterious	0.75	deleterious	-2.36	low_impact	-0.84	medium_impact	1.6	medium_impact	0.58	0.9	50	8.78	0.28	N	0.92	polymorphism	0.92	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15266	15266	A	G	MI.9430	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	520	174	T	A	Acc/Gcc	-14.5	0	0	probably_damaging	0.99	neutral	0.89	neutral	2.86	neutral	-2.12	deleterious	-4.09	high_impact	4.59	0.77	neutral	0.52	neutral	2.35	18.47	deleterious	0.13	0.4	0.57	disease	0.68	disease	0.75	disease	0.69	disease	4	0.99	deleterious	0.45	neutral	2	deleterious	0.76	deleterious	-2.59	low_impact	0.71	medium_impact	2.97	high_impact	0.28	0.8	57.63	8.75	0.43	N	0.59	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15267	15267	C	T	MI.9431	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	521	174	T	I	aCc/aTc	8.44	1	0	probably_damaging	1	neutral	0.48	neutral	2.94	neutral	-2.05	deleterious	-4.92	high_impact	5.08	0.84	neutral	0.46	neutral	3.93	23.50	deleterious	0.07	0.35	0.57	disease	0.86	disease	0.76	disease	0.69	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.2	medium_impact	3.42	high_impact	0.50	0.8	57.63	8.75	0.75	P	0.83	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15267	15267	C	G	MI.9432	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	521	174	T	S	aCc/aGc	8.44	1	0	probably_damaging	0.99	neutral	0.69	neutral	2.83	deleterious	-3.15	deleterious	-3.27	high_impact	4.74	0.84	neutral	0.47	neutral	1.94	15.85	deleterious	0.22	0.45	0.64	disease	0.71	disease	0.68	disease	0.65	disease	3	0.99	deleterious	0.35	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.41	medium_impact	3.11	high_impact	0.39	0.8	57.63	8.75	0.7	P	0.81	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15267	15267	C	A	MI.9433	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	521	174	T	N	aCc/aAc	8.44	1	0	probably_damaging	1	neutral	0.54	neutral	2.81	deleterious	-4.54	deleterious	-4.09	high_impact	5.29	0.83	neutral	0.42	neutral	3.49	23.10	deleterious	0.21	0.45	0.76	disease	0.85	disease	0.78	disease	0.68	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.26	medium_impact	3.61	high_impact	0.46	0.8	57.63	8.75	0.76	P	0.84	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15269	15269	C	A	MI.9434	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	523	175	L	I	Ctc/Atc	-8.99	0	0	probably_damaging	1	neutral	0.4	neutral	3.01	neutral	-2.64	neutral	-1.64	high_impact	4.13	0.88	neutral	0.06	damaging	3.89	23.50	deleterious	0.22	0.45	0.41	neutral	0.68	disease	0.61	disease	0.65	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.13	medium_impact	2.56	high_impact	0.69	0.85	58.95	8.72	0.32	N	0.86	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15269	15269	C	G	MI.9435	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	523	175	L	V	Ctc/Gtc	-8.99	0	0	probably_damaging	0.99	neutral	0.51	neutral	2.91	neutral	-2.57	neutral	-2.46	high_impact	5.28	0.82	neutral	0.08	damaging	3.05	22.40	deleterious	0.17	0.45	0.5	disease	0.69	disease	0.63	disease	0.65	disease	3	0.99	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-2.59	low_impact	0.23	medium_impact	3.6	high_impact	0.54	0.8	58.95	8.72	0.62	P	0.91	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15269	15269	C	T	MI.9436	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	523	175	L	F	Ctc/Ttc	-8.99	0	0	probably_damaging	1	neutral	0.73	neutral	2.97	deleterious	-3.07	deleterious	-3.27	high_impact	4.82	0.91	neutral	0.05	damaging	3.88	23.50	deleterious	0.09	0.35	0.66	disease	0.77	disease	0.64	disease	0.66	disease	3	1	deleterious	0.37	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.46	medium_impact	3.18	high_impact	0.61	0.8	58.95	8.72	0.6	P	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15270	15270	T	A	MI.9437	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	524	175	L	H	cTc/cAc	-0.73	0	0	probably_damaging	1	neutral	0.55	neutral	2.77	deleterious	-5.87	deleterious	-5.74	high_impact	5.62	0.88	neutral	0.06	damaging	4.09	23.70	deleterious	0.02	0.35	0.84	disease	0.84	disease	0.72	disease	0.66	disease	3	1	deleterious	0.28	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.27	medium_impact	3.91	high_impact	0.28	0.8	58.95	8.72	0.6	P	0.95	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15270	15270	T	G	MI.9438	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	524	175	L	R	cTc/cGc	-0.73	0	0	probably_damaging	1	neutral	0.35	neutral	2.78	deleterious	-5.13	deleterious	-4.92	high_impact	5.62	0.84	neutral	0.03	damaging	4.14	23.80	deleterious	0.01	0.35	0.76	disease	0.89	disease	0.75	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.08	medium_impact	3.91	high_impact	0.11	0.8	58.95	8.72	0.7	P	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15270	15270	T	C	MI.9439	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	524	175	L	P	cTc/cCc	-0.73	0	0	probably_damaging	1	neutral	0.21	neutral	2.77	deleterious	-5.53	deleterious	-5.75	high_impact	5.62	0.87	neutral	0.03	damaging	3.88	23.50	deleterious	0.01	0.35	0.85	disease	0.79	disease	0.74	disease	0.67	disease	3	1	deleterious	0.11	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.09	medium_impact	3.91	high_impact	0.17	0.8	58.95	8.72	0.6	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8968	8968	A	C	MI.944	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	442	148	S	R	Agc/Cgc	-5.89	0	0	probably_damaging	0.99	deleterious	0	neutral	3.45	deleterious	-3.22	deleterious	-4.57	high_impact	4.04	0.49	damaging	0.05	damaging	3.85	23.40	deleterious	0.19	0.65	0.76	disease	0.88	disease	0.79	disease	0.77	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-2.65	low_impact	-1.4	low_impact	2.36	high_impact	0.64	0.9	50	8.78	0.39	N	1.00	polymorphism	0.71	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15272	15272	A	C	MI.9440	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	526	176	T	P	Aca/Cca	-13.81	0	0	probably_damaging	1	neutral	0.18	neutral	3.13	neutral	-0.72	deleterious	-4.64	high_impact	4.67	0.84	neutral	0.3	neutral	3.45	23.00	deleterious	0.04	0.35	0.66	disease	0.82	disease	0.7	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.14	medium_impact	3.05	high_impact	0.29	0.8	21.84	16.54	0.54	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15272	15272	A	G	MI.9441	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	526	176	T	A	Aca/Gca	-13.81	0	0	probably_damaging	0.99	neutral	0.4	neutral	3.11	neutral	-1.06	deleterious	-3.73	high_impact	4.67	0.77	neutral	0.6	neutral	3.07	22.40	deleterious	0.16	0.45	0.4	neutral	0.64	disease	0.56	disease	0.5	disease	0	0.99	deleterious	0.21	neutral	2	deleterious	0.71	deleterious	-2.59	low_impact	0.13	medium_impact	3.05	high_impact	0.42	0.8	21.84	16.54	0.54	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15272	15272	A	T	MI.9442	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	526	176	T	S	Aca/Tca	-13.81	0	0	probably_damaging	0.99	neutral	0.37	neutral	3.22	neutral	-0.56	deleterious	-2.92	medium_impact	3	0.89	neutral	0.5	neutral	2.90	21.90	deleterious	0.21	0.45	0.31	neutral	0.72	disease	0.32	neutral	0.35	neutral	3	0.99	deleterious	0.19	neutral	1	deleterious	0.72	deleterious	-2.59	low_impact	0.1	medium_impact	1.53	medium_impact	0.58	0.8	21.84	16.54	0.34	N	0.81	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15273	15273	C	T	MI.9443	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	527	176	T	M	aCa/aTa	6.84	1	0	probably_damaging	1	neutral	0.15	neutral	3.04	deleterious	-3.4	deleterious	-4.51	high_impact	4.18	0.89	neutral	0.52	neutral	4.02	23.60	deleterious	0.08	0.35	0.72	disease	0.8	disease	0.49	neutral	0.59	disease	2	1	deleterious	0.08	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	-0.19	medium_impact	2.6	high_impact	0.47	0.8	21.84	16.54	0.58	P	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15273	15273	C	A	MI.9444	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	527	176	T	K	aCa/aAa	6.84	1	0	probably_damaging	1	neutral	0.23	neutral	3.16	neutral	-0.7	deleterious	-4.58	medium_impact	3.25	0.84	neutral	0.35	neutral	4.29	24.00	deleterious	0.06	0.35	0.26	neutral	0.87	disease	0.62	disease	0.67	disease	3	1	deleterious	0.12	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	-0.06	medium_impact	1.76	medium_impact	0.29	0.8	21.84	16.54	0.52	P	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15275	15275	C	G	MI.9445	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	529	177	R	G	Cga/Gga	-10.6	0	0	probably_damaging	1	neutral	0.35	neutral	2.55	deleterious	-7.05	deleterious	-5.74	high_impact	4.81	0.95	neutral	0.09	damaging	4.21	23.90	deleterious	0.03	0.35	0.7	disease	0.76	disease	0.75	disease	0.69	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.08	medium_impact	3.17	high_impact	0.14	0.8	57.11	8.54	0.63	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15275	15275	C	T	MI.9446	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	529	177	R	W	Cga/Tga	-10.6	0	0	probably_damaging	1	neutral	0.18	neutral	2.54	deleterious	-8.82	deleterious	-6.57	high_impact	4.92	0.94	neutral	0.06	damaging	5.21	25.60	deleterious	0.05	0.35	0.65	disease	0.83	disease	0.77	disease	0.7	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.14	medium_impact	3.27	high_impact	0.53	0.8	57.11	8.54	0.6	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15276	15276	G	A	MI.9447	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	530	177	R	Q	cGa/cAa	3.4	0.99	0	probably_damaging	1	neutral	0.29	neutral	2.57	deleterious	-5.61	deleterious	-3.28	high_impact	4.92	0.93	neutral	0.05	damaging	4.54	24.30	deleterious	0.13	0.4	0.55	disease	0.78	disease	0.78	disease	0.69	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.01	medium_impact	3.27	high_impact	0.72	0.85	57.11	8.54	0.74	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	COSM6716241	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15276	15276	G	C	MI.9448	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	530	177	R	P	cGa/cCa	3.4	0.99	0	probably_damaging	1	neutral	0.26	neutral	2.54	deleterious	-7.54	deleterious	-5.75	high_impact	5.27	0.93	neutral	0.04	damaging	4.23	23.90	deleterious	0.01	0.35	0.77	disease	0.81	disease	0.85	disease	0.72	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	-0.02	medium_impact	3.59	high_impact	0.08	0.8	57.11	8.54	0.66	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15276	15276	G	T	MI.9449	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	530	177	R	L	cGa/cTa	3.4	0.99	0	probably_damaging	1	neutral	0.87	neutral	2.61	deleterious	-6.3	deleterious	-5.74	high_impact	4.72	0.94	neutral	0.06	damaging	4.25	23.90	deleterious	0.03	0.35	0.63	disease	0.88	disease	0.75	disease	0.7	disease	4	1	deleterious	0.44	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.67	medium_impact	3.09	high_impact	0.03	0.8	57.11	8.54	0.65	P	1.00	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8969	8969	G	C	MI.945	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	443	148	S	T	aGc/aCc	8.69	1	0	probably_damaging	0.98	deleterious	0	neutral	3.46	neutral	-2.98	deleterious	-2.72	high_impact	4.04	0.51	damaging	0.08	damaging	3.46	23.00	deleterious	0.22	0.65	0.81	disease	0.65	disease	0.7	disease	0.71	disease	4	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.36	low_impact	-1.4	low_impact	2.36	high_impact	0.71	0.9	50	8.78	0.5	P	0.67	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15278	15278	T	G	MI.9450	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	532	178	F	V	Ttc/Gtc	-0.73	0.09	0	possibly_damaging	0.68	neutral	0.43	neutral	3.09	deleterious	-3.15	deleterious	-5.74	high_impact	4.53	0.88	neutral	0.11	damaging	4.06	23.70	deleterious	0.07	0.35	0.39	neutral	0.84	disease	0.76	disease	0.7	disease	4	0.69	neutral	0.38	neutral	1	deleterious	0.59	deleterious	-1.04	low_impact	0.16	medium_impact	2.92	high_impact	0.43	0.8	57.37	8.65	0.49	N	0.99	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15278	15278	T	A	MI.9451	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	532	178	F	I	Ttc/Atc	-0.73	0.09	0	benign	0.36	neutral	0.38	neutral	3.07	neutral	-2.53	deleterious	-4.92	high_impact	5.08	0.87	neutral	0.12	damaging	4.28	24.00	deleterious	0.11	0.4	0.5	neutral	0.79	disease	0.75	disease	0.69	disease	4	0.55	neutral	0.51	deleterious	-2	neutral	0.56	deleterious	-0.5	medium_impact	0.11	medium_impact	3.42	high_impact	0.50	0.8	57.37	8.65	0.63	P	0.97	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15278	15278	T	C	MI.9452	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	532	178	F	L	Ttc/Ctc	-0.73	0.09	0	benign	0.02	neutral	0.65	neutral	3.25	neutral	-0.76	deleterious	-4.92	high_impact	4.27	0.93	neutral	0.15	damaging	3.79	23.40	deleterious	0.14	0.4	0.4	neutral	0.74	disease	0.68	disease	0.65	disease	3	0.31	neutral	0.82	deleterious	-2	neutral	0.24	neutral	0.85	medium_impact	0.37	medium_impact	2.68	high_impact	0.68	0.85	57.37	8.65	0.31	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15279	15279	T	A	MI.9453	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	533	178	F	Y	tTc/tAc	7.3	1	0	possibly_damaging	0.72	neutral	0.8	neutral	2.91	deleterious	-4.57	neutral	-2.46	high_impact	5.62	0.88	neutral	0.11	damaging	4.16	23.80	deleterious	0.13	0.4	0.7	disease	0.74	disease	0.72	disease	0.68	disease	4	0.67	neutral	0.54	deleterious	1	deleterious	0.73	deleterious	-1.11	low_impact	0.55	medium_impact	3.91	high_impact	0.62	0.8	57.37	8.65	0.72	P	0.87	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15279	15279	T	G	MI.9454	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	533	178	F	C	tTc/tGc	7.3	1	0	probably_damaging	0.99	neutral	0.14	neutral	2.89	deleterious	-6.95	deleterious	-6.57	high_impact	5.62	0.87	neutral	0.09	damaging	4.07	23.70	deleterious	0.03	0.35	0.83	disease	0.84	disease	0.76	disease	0.68	disease	4	0.99	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	-0.21	medium_impact	3.91	high_impact	0.24	0.8	57.37	8.65	0.67	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15279	15279	T	C	MI.9455	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	533	178	F	S	tTc/tCc	7.3	1	0	probably_damaging	0.94	neutral	0.42	neutral	2.92	deleterious	-6.42	deleterious	-6.55	high_impact	5.28	0.86	neutral	0.08	damaging	4.24	23.90	deleterious	0.02	0.35	0.66	disease	0.82	disease	0.74	disease	0.7	disease	4	0.94	neutral	0.24	neutral	2	deleterious	0.81	deleterious	-1.85	low_impact	0.15	medium_impact	3.6	high_impact	0.33	0.8	57.37	8.65	0.68	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15280	15280	C	G	MI.9456	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	534	178	F	L	ttC/ttG	5.69	1	0	benign	0.02	neutral	0.65	neutral	3.25	neutral	-0.76	deleterious	-4.92	high_impact	4.27	0.93	neutral	0.15	damaging	4.06	23.70	deleterious	0.14	0.4	0.4	neutral	0.74	disease	0.68	disease	0.65	disease	3	0.31	neutral	0.82	deleterious	-2	neutral	0.24	neutral	0.85	medium_impact	0.37	medium_impact	2.68	high_impact	0.68	0.85	57.37	8.65	0.52	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15280	15280	C	A	MI.9457	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	534	178	F	L	ttC/ttA	5.69	1	0	benign	0.02	neutral	0.65	neutral	3.25	neutral	-0.76	deleterious	-4.92	high_impact	4.27	0.93	neutral	0.15	damaging	4.34	24.00	deleterious	0.14	0.4	0.4	neutral	0.74	disease	0.68	disease	0.65	disease	3	0.31	neutral	0.82	deleterious	-2	neutral	0.24	neutral	0.85	medium_impact	0.37	medium_impact	2.68	high_impact	0.68	0.85	57.37	8.65	0.52	N	0.92	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15281	15281	T	G	MI.9458	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	535	179	F	V	Ttt/Gtt	-0.96	0.02	0	probably_damaging	1	neutral	0.18	neutral	3.02	deleterious	-3.42	deleterious	-5.7	high_impact	5.53	0.88	neutral	0.12	damaging	3.85	23.40	deleterious	0.06	0.35	0.81	disease	0.87	disease	0.66	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.14	medium_impact	3.83	high_impact	0.33	0.8	56.05	8.81	0.64	P	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15281	15281	T	A	MI.9459	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	535	179	F	I	Ttt/Att	-0.96	0.02	0	probably_damaging	1	neutral	0.1	neutral	3.01	deleterious	-3.84	deleterious	-4.89	high_impact	5.53	0.87	neutral	0.12	damaging	4.14	23.80	deleterious	0.1	0.4	0.81	disease	0.83	disease	0.65	disease	0.68	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.3	medium_impact	3.83	high_impact	0.53	0.8	56.05	8.81	0.64	P	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8969	8969	G	A	MI.946	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	443	148	S	N	aGc/aAc	8.69	1	0	probably_damaging	0.98	deleterious	0	neutral	3.46	neutral	-2.96	deleterious	-2.76	high_impact	4.59	0.47	damaging	0.07	damaging	3.63	23.20	deleterious	0.45	0.65	0.8	disease	0.71	disease	0.71	disease	0.73	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.81	deleterious	-2.36	low_impact	-1.4	low_impact	2.84	high_impact	0.44	0.9	50	8.78	0.57	P	0.88	disease_causing_automatic	1	0.33	rs794726857	Pathogenic	Myopathy,_lactic_acidosis,_and_sideroblastic_anemia_3	189167	MedGen:C4225415,OMIM:500011	.	.	.	.	G8969A	Mitochondrial myopathy, lactic acidosis and sideroblastic anemia (MLASA)	-	+	Reported	1	P	P	P	damaging
chrM	15281	15281	T	C	MI.9460	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	535	179	F	L	Ttt/Ctt	-0.96	0.02	0	probably_damaging	1	neutral	0.59	neutral	3.25	neutral	-1.99	deleterious	-4.89	high_impact	4.49	0.92	neutral	0.1	damaging	3.60	23.20	deleterious	0.13	0.4	0.67	disease	0.77	disease	0.58	disease	0.57	disease	1	1	deleterious	0.3	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.31	medium_impact	2.88	high_impact	0.59	0.8	56.05	8.81	0.37	N	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15282	15282	T	C	MI.9461	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	536	179	F	S	tTt/tCt	5.69	1	0	probably_damaging	1	neutral	0.12	neutral	2.95	deleterious	-4.68	deleterious	-6.52	high_impact	4.97	0.91	neutral	0.1	damaging	4.18	23.80	deleterious	0.02	0.35	0.88	disease	0.84	disease	0.64	disease	0.67	disease	3	1	deleterious	0.06	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.25	medium_impact	3.32	high_impact	0.40	0.8	56.05	8.81	0.7	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15282	15282	T	G	MI.9462	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	536	179	F	C	tTt/tGt	5.69	1	0	probably_damaging	1	deleterious	0.03	neutral	2.93	deleterious	-6.1	deleterious	-6.53	high_impact	5.17	0.87	neutral	0.1	damaging	4.04	23.70	deleterious	0.03	0.35	0.95	disease	0.86	disease	0.61	disease	0.66	disease	3	1	deleterious	0.02	neutral	6	deleterious	0.84	deleterious	-3.53	low_impact	-0.6	medium_impact	3.5	high_impact	0.30	0.8	56.05	8.81	0.63	P	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15282	15282	T	A	MI.9463	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	536	179	F	Y	tTt/tAt	5.69	1	0	probably_damaging	1	neutral	0.19	neutral	3.2	neutral	-0.26	neutral	-2.41	medium_impact	2.73	0.88	neutral	0.12	damaging	3.91	23.50	deleterious	0.15	0.4	0.35	neutral	0.76	disease	0.5	neutral	0.41	neutral	2	1	deleterious	0.1	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	-0.12	medium_impact	1.29	medium_impact	0.58	0.8	56.05	8.81	0.49	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15283	15283	T	A	MI.9464	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	537	179	F	L	ttT/ttA	5.69	1	0	probably_damaging	1	neutral	0.59	neutral	3.25	neutral	-1.99	deleterious	-4.89	high_impact	4.49	0.92	neutral	0.1	damaging	4.09	23.70	deleterious	0.13	0.4	0.67	disease	0.77	disease	0.58	disease	0.57	disease	1	1	deleterious	0.3	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.31	medium_impact	2.88	high_impact	0.59	0.8	56.05	8.81	0.56	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15283	15283	T	G	MI.9465	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	537	179	F	L	ttT/ttG	5.69	1	0	probably_damaging	1	neutral	0.59	neutral	3.25	neutral	-1.99	deleterious	-4.89	high_impact	4.49	0.92	neutral	0.1	damaging	3.96	23.60	deleterious	0.13	0.4	0.67	disease	0.77	disease	0.58	disease	0.57	disease	1	1	deleterious	0.3	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.31	medium_impact	2.88	high_impact	0.59	0.8	56.05	8.81	0.55	P	0.92	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15284	15284	A	C	MI.9466	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	538	180	T	P	Acc/Ccc	-5.55	0	0	probably_damaging	1	neutral	0.17	neutral	3.09	neutral	-2.59	neutral	-2.27	high_impact	3.76	0.88	neutral	0.21	damaging	3.34	22.90	deleterious	0.06	0.35	0.63	disease	0.88	disease	0.73	disease	0.76	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.15	medium_impact	2.22	high_impact	0.48	0.8	23.42	45.05	0.38	N	0.67	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15284	15284	A	T	MI.9467	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	538	180	T	S	Acc/Tcc	-5.55	0	0	probably_damaging	1	neutral	0.2	neutral	3.16	neutral	0.76	neutral	-0.64	neutral_impact	0.56	0.86	neutral	0.25	damaging	2.96	22.10	deleterious	0.16	0.45	0.17	neutral	0.57	disease	0.36	neutral	0.23	neutral	5	1	deleterious	0.1	neutral	-2	neutral	0.67	deleterious	-3.53	low_impact	-0.1	medium_impact	-0.69	medium_impact	0.61	0.8	23.42	45.05	0.3	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15284	15284	A	G	MI.9468	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	538	180	T	A	Acc/Gcc	-5.55	0	0	probably_damaging	1	neutral	0.55	neutral	3.36	neutral	1.31	neutral	0.6	neutral_impact	0	0.95	neutral	0.92	neutral	0.39	6.50	deleterious	0.15	0.4	0.15	neutral	0.06	neutral	0.32	neutral	0.19	neutral	6	1	deleterious	0.28	neutral	-2	neutral	0.63	deleterious	-3.53	low_impact	0.27	medium_impact	-1.19	low_impact	0.42	0.8	23.42	45.05	0.37	N	0.01	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15285	15285	C	T	MI.9469	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	539	180	T	I	aCc/aTc	2.94	0.95	0	probably_damaging	1	neutral	0.36	neutral	3.19	neutral	0.57	neutral	-2.12	medium_impact	3.28	0.86	neutral	0.26	damaging	3.84	23.40	deleterious	0.08	0.35	0.43	neutral	0.81	disease	0.56	disease	0.7	disease	4	1	deleterious	0.18	neutral	1	deleterious	0.74	deleterious	-3.53	low_impact	0.09	medium_impact	1.79	medium_impact	0.62	0.8	23.42	45.05	0.38	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8969	8969	G	T	MI.947	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	443	148	S	I	aGc/aTc	8.69	1	0	probably_damaging	0.99	deleterious	0	neutral	3.4	deleterious	-6.11	deleterious	-5.48	high_impact	4.59	0.49	damaging	0.06	damaging	4.16	23.80	deleterious	0.2	0.65	0.92	disease	0.9	disease	0.7	disease	0.79	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.86	deleterious	-2.65	low_impact	-1.4	low_impact	2.84	high_impact	0.68	0.9	50	8.78	0.48	P	1.00	disease_causing	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15285	15285	C	G	MI.9470	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	539	180	T	S	aCc/aGc	2.94	0.95	0	probably_damaging	1	neutral	0.2	neutral	3.16	neutral	0.76	neutral	-0.64	neutral_impact	0.56	0.86	neutral	0.25	damaging	3.19	22.70	deleterious	0.16	0.45	0.17	neutral	0.57	disease	0.36	neutral	0.23	neutral	5	1	deleterious	0.1	neutral	-2	neutral	0.67	deleterious	-3.53	low_impact	-0.1	medium_impact	-0.69	medium_impact	0.61	0.8	23.42	45.05	0.34	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15285	15285	C	A	MI.9471	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	539	180	T	N	aCc/aAc	2.94	0.95	0	probably_damaging	1	neutral	0.19	neutral	3.08	neutral	-2.35	neutral	-2.48	high_impact	4.57	0.86	neutral	0.26	damaging	3.47	23.00	deleterious	0.18	0.45	0.51	disease	0.83	disease	0.62	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	-0.12	medium_impact	2.96	high_impact	0.65	0.8	23.42	45.05	0.51	N	0.60	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15287	15287	T	G	MI.9472	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	541	181	F	V	Ttt/Gtt	-4.86	0	0.01	benign	0.28	neutral	0.26	neutral	3.19	neutral	0.19	deleterious	-3.89	high_impact	3.84	0.95	neutral	0.49	neutral	3.79	23.40	deleterious	0.07	0.35	0.31	neutral	0.86	disease	0.7	disease	0.72	disease	4	0.69	neutral	0.49	deleterious	-2	neutral	0.27	neutral	-0.35	medium_impact	-0.02	medium_impact	2.29	high_impact	0.39	0.8	20.79	34.54	0.44	N	0.78	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15287	15287	T	C	MI.9473	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	541	181	F	L	Ttt/Ctt	-4.86	0	0.01	benign	0	neutral	0.65	neutral	3.45	neutral	2.72	deleterious	-2.69	low_impact	0.91	0.96	neutral	0.78	neutral	1.05	10.92	neutral	0.19	0.45	0.16	neutral	0.56	disease	0.51	disease	0.23	neutral	5	0.34	neutral	0.83	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.37	medium_impact	-0.37	medium_impact	0.51	0.8	20.79	34.54	0.3	N	0.08	polymorphism	1	0.04	rs527236044	Likely_pathogenic	Familial_cancer_of_breast	150282	MedGen:C0346153,OMIM:114480,Orphanet:ORPHA227535,SNOMED_CT:254843006	.	.	.	12.93	T15287C	Possible DEAF helper mut.	-	+	Further studies needed	1	P	N	P,N	neutral
chrM	15287	15287	T	A	MI.9474	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	541	181	F	I	Ttt/Att	-4.86	0	0.01	benign	0.1	neutral	0.37	neutral	3.18	neutral	0.33	deleterious	-3.07	medium_impact	2.72	0.94	neutral	0.48	neutral	3.94	23.50	deleterious	0.1	0.4	0.35	neutral	0.8	disease	0.54	disease	0.27	neutral	5	0.58	neutral	0.64	deleterious	-3	neutral	0.24	neutral	0.16	medium_impact	0.1	medium_impact	1.28	medium_impact	0.47	0.8	20.79	34.54	0.3	N	0.68	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15288	15288	T	A	MI.9475	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	542	181	F	Y	tTt/tAt	0.64	0.47	0	possibly_damaging	0.44	neutral	0.53	neutral	3.1	neutral	-1.3	neutral	-2.01	high_impact	5.19	0.98	neutral	0.47	neutral	2.48	19.33	deleterious	0.14	0.4	0.55	disease	0.78	disease	0.7	disease	0.7	disease	4	0.44	neutral	0.55	deleterious	1	deleterious	0.42	neutral	-0.63	medium_impact	0.25	medium_impact	3.52	high_impact	0.50	0.8	20.79	34.54	0.55	P	0.71	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15288	15288	T	G	MI.9476	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	542	181	F	C	tTt/tGt	0.64	0.47	0	probably_damaging	0.91	neutral	0.1	neutral	3.07	neutral	-2.71	deleterious	-4.98	high_impact	4.84	0.94	neutral	0.39	neutral	4.06	23.70	deleterious	0.02	0.35	0.69	disease	0.86	disease	0.73	disease	0.72	disease	4	0.97	neutral	0.1	neutral	2	deleterious	0.74	deleterious	-1.67	low_impact	-0.3	medium_impact	3.2	high_impact	0.32	0.8	20.79	34.54	0.63	P	0.79	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15288	15288	T	C	MI.9477	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	542	181	F	S	tTt/tCt	0.64	0.47	0	benign	0.03	neutral	0.23	neutral	3.09	neutral	-1.18	deleterious	-5.2	high_impact	4.84	0.93	neutral	0.47	neutral	3.94	23.50	deleterious	0.02	0.35	0.37	neutral	0.82	disease	0.7	disease	0.69	disease	4	0.76	neutral	0.6	deleterious	-2	neutral	0.23	neutral	0.68	medium_impact	-0.06	medium_impact	3.2	high_impact	0.46	0.8	20.79	34.54	0.54	N	0.91	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15289	15289	T	G	MI.9478	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	543	181	F	L	ttT/ttG	7.3	0.98	0.01	benign	0	neutral	0.65	neutral	3.45	neutral	2.72	deleterious	-2.69	low_impact	0.91	0.96	neutral	0.78	neutral	1.41	12.84	neutral	0.19	0.45	0.16	neutral	0.56	disease	0.51	disease	0.23	neutral	5	0.34	neutral	0.83	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.37	medium_impact	-0.37	medium_impact	0.51	0.8	20.79	34.54	0.51	N	0.08	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15289	15289	T	A	MI.9479	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	543	181	F	L	ttT/ttA	7.3	0.98	0.01	benign	0	neutral	0.65	neutral	3.45	neutral	2.72	deleterious	-2.69	low_impact	0.91	0.96	neutral	0.78	neutral	1.49	13.24	neutral	0.19	0.45	0.16	neutral	0.56	disease	0.51	disease	0.23	neutral	5	0.34	neutral	0.83	deleterious	-6	neutral	0.14	neutral	2.07	high_impact	0.37	medium_impact	-0.37	medium_impact	0.51	0.8	20.79	34.54	0.51	P	0.08	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8971	8971	C	G	MI.948	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	445	149	L	V	Cta/Gta	-0.57	0	0	probably_damaging	0.99	neutral	0.38	neutral	4.2	neutral	-1.06	deleterious	-2.73	medium_impact	2.1	0.71	neutral	0.44	neutral	3.44	23.00	deleterious	0.48	0.65	0.62	disease	0.64	disease	0.48	neutral	0.46	neutral	1	0.99	deleterious	0.2	neutral	1	deleterious	0.79	deleterious	-2.65	low_impact	0.17	medium_impact	0.7	medium_impact	0.63	0.9	49.56	8.82	0.27	N	0.87	disease_causing	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15290	15290	C	G	MI.9480	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	544	182	H	D	Cac/Gac	-6.47	0	0	probably_damaging	1	neutral	0.07	neutral	1.72	deleterious	-9.72	deleterious	-7.42	high_impact	5.63	0.92	neutral	0.36	neutral	3.69	23.30	deleterious	0.05	0.35	0.74	disease	0.83	disease	0.83	disease	0.72	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.39	medium_impact	3.92	high_impact	0.37	0.8	56.58	8.81	0.6	P	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15290	15290	C	A	MI.9481	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	544	182	H	N	Cac/Aac	-6.47	0	0	probably_damaging	1	neutral	0.15	neutral	1.72	deleterious	-8.79	deleterious	-5.77	high_impact	4.95	0.92	neutral	0.43	neutral	3.53	23.10	deleterious	0.19	0.45	0.71	disease	0.84	disease	0.76	disease	0.73	disease	5	1	deleterious	0.08	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.19	medium_impact	3.3	high_impact	0.42	0.8	56.58	8.81	0.64	P	0.97	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15290	15290	C	T	MI.9482	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	544	182	H	Y	Cac/Tac	-6.47	0	0	probably_damaging	1	neutral	0.42	neutral	1.72	deleterious	-8.53	deleterious	-4.95	high_impact	5.29	0.93	neutral	0.39	neutral	3.36	22.90	deleterious	0.11	0.4	0.63	disease	0.87	disease	0.79	disease	0.72	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.15	medium_impact	3.61	high_impact	0.36	0.8	56.58	8.81	0.72	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15291	15291	A	T	MI.9483	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	545	182	H	L	cAc/cTc	4.31	0.99	0	probably_damaging	1	neutral	0.67	neutral	1.72	deleterious	-9.35	deleterious	-9.07	high_impact	5.08	0.94	neutral	0.38	neutral	3.48	23.10	deleterious	0.03	0.35	0.44	neutral	0.9	disease	0.78	disease	0.73	disease	5	1	deleterious	0.34	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.39	medium_impact	3.42	high_impact	0.25	0.8	56.58	8.81	0.63	P	0.92	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15291	15291	A	C	MI.9484	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	545	182	H	P	cAc/cCc	4.31	0.99	0	probably_damaging	1	neutral	0.18	neutral	1.72	deleterious	-9.92	deleterious	-8.24	high_impact	5.08	0.94	neutral	0.28	damaging	3.03	22.30	deleterious	0.03	0.35	0.83	disease	0.87	disease	0.83	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.14	medium_impact	3.42	high_impact	0.29	0.8	56.58	8.81	0.63	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15291	15291	A	G	MI.9485	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	545	182	H	R	cAc/cGc	4.31	0.99	0	probably_damaging	1	neutral	0.19	neutral	1.74	deleterious	-9.36	deleterious	-6.59	high_impact	5.08	0.94	neutral	0.34	neutral	2.67	20.60	deleterious	0.08	0.35	0.56	disease	0.9	disease	0.8	disease	0.75	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.12	medium_impact	3.42	high_impact	0.36	0.8	56.58	8.81	0.64	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15292	15292	C	A	MI.9486	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	546	182	H	Q	caC/caA	8.44	1	0.01	probably_damaging	1	neutral	0.1	neutral	1.72	deleterious	-9.43	deleterious	-6.59	high_impact	5.08	0.94	neutral	0.36	neutral	3.55	23.10	deleterious	0.12	0.4	0.65	disease	0.81	disease	0.78	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	-0.3	medium_impact	3.42	high_impact	0.42	0.8	56.58	8.81	0.65	P	0.94	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15292	15292	C	G	MI.9487	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	546	182	H	Q	caC/caG	8.44	1	0.01	probably_damaging	1	neutral	0.1	neutral	1.72	deleterious	-9.43	deleterious	-6.59	high_impact	5.08	0.94	neutral	0.36	neutral	3.28	22.80	deleterious	0.12	0.4	0.65	disease	0.81	disease	0.78	disease	0.72	disease	4	1	deleterious	0.05	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	-0.3	medium_impact	3.42	high_impact	0.42	0.8	56.58	8.81	0.64	P	0.94	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15293	15293	T	G	MI.9488	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	547	183	F	V	Ttc/Gtc	-0.73	0.05	0	probably_damaging	1	neutral	0.35	neutral	3.4	neutral	1.45	deleterious	-5.75	high_impact	4.11	0.95	neutral	0.11	damaging	4.11	23.70	deleterious	0.06	0.35	0.45	neutral	0.88	disease	0.69	disease	0.71	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.08	medium_impact	2.54	high_impact	0.46	0.8	57.37	8.61	0.38	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15293	15293	T	C	MI.9489	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	547	183	F	L	Ttc/Ctc	-0.73	0.05	0	probably_damaging	1	neutral	0.79	neutral	3.15	neutral	-0.29	deleterious	-4.93	high_impact	4.58	0.96	neutral	0.1	damaging	3.88	23.50	deleterious	0.11	0.4	0.34	neutral	0.84	disease	0.6	disease	0.69	disease	4	1	deleterious	0.4	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	0.53	medium_impact	2.97	high_impact	0.59	0.8	57.37	8.61	0.36	N	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8971	8971	C	A	MI.949	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	445	149	L	M	Cta/Ata	-0.57	0	0	probably_damaging	1	neutral	0.15	neutral	4.18	neutral	-2.43	neutral	-1.82	medium_impact	2.8	0.8	neutral	0.5	neutral	3.75	23.30	deleterious	0.38	0.65	0.76	disease	0.54	disease	0.36	neutral	0.48	neutral	0	1	deleterious	0.08	neutral	1	deleterious	0.78	deleterious	-3.6	low_impact	-0.13	medium_impact	1.3	medium_impact	0.58	0.9	49.56	8.82	0.36	N	0.96	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15293	15293	T	A	MI.9490	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	547	183	F	I	Ttc/Atc	-0.73	0.05	0	probably_damaging	1	neutral	0.29	neutral	3.58	neutral	2	deleterious	-4.93	high_impact	4.75	0.94	neutral	0.12	damaging	4.43	24.20	deleterious	0.09	0.35	0.34	neutral	0.87	disease	0.62	disease	0.7	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.01	medium_impact	3.12	high_impact	0.63	0.8	57.37	8.61	0.62	P	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15294	15294	T	G	MI.9491	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	548	183	F	C	tTc/tGc	5.69	1	0	probably_damaging	1	neutral	0.08	neutral	3.05	neutral	-2.55	deleterious	-6.58	high_impact	4.86	0.94	neutral	0.09	damaging	4.09	23.70	deleterious	0.03	0.35	0.79	disease	0.88	disease	0.69	disease	0.7	disease	4	1	deleterious	0.04	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.35	medium_impact	3.22	high_impact	0.28	0.8	57.37	8.61	0.7	P	0.99	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15294	15294	T	A	MI.9492	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	548	183	F	Y	tTc/tAc	5.69	1	0	probably_damaging	1	neutral	0.6	neutral	3.07	neutral	-1.6	neutral	-2.45	medium_impact	2.54	0.94	neutral	0.13	damaging	3.94	23.50	deleterious	0.13	0.4	0.24	neutral	0.81	disease	0.52	disease	0.55	disease	1	1	deleterious	0.3	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	0.32	medium_impact	1.11	medium_impact	0.63	0.8	57.37	8.61	0.45	N	0.87	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15294	15294	T	C	MI.9493	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	548	183	F	S	tTc/tCc	5.69	1	0	probably_damaging	1	neutral	0.31	neutral	3.05	neutral	-2.3	deleterious	-6.57	high_impact	5.2	0.93	neutral	0.08	damaging	4.20	23.90	deleterious	0.02	0.35	0.43	neutral	0.85	disease	0.68	disease	0.71	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.03	medium_impact	3.53	high_impact	0.52	0.8	57.37	8.61	0.68	P	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15295	15295	C	G	MI.9494	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	549	183	F	L	ttC/ttG	5.69	1	0	probably_damaging	1	neutral	0.79	neutral	3.15	neutral	-0.29	deleterious	-4.93	high_impact	4.58	0.96	neutral	0.1	damaging	4.05	23.70	deleterious	0.11	0.4	0.34	neutral	0.84	disease	0.6	disease	0.69	disease	4	1	deleterious	0.4	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	0.53	medium_impact	2.97	high_impact	0.59	0.8	57.37	8.61	0.51	P	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15295	15295	C	A	MI.9495	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	549	183	F	L	ttC/ttA	5.69	1	0	probably_damaging	1	neutral	0.79	neutral	3.15	neutral	-0.29	deleterious	-4.93	high_impact	4.58	0.96	neutral	0.1	damaging	4.41	24.10	deleterious	0.11	0.4	0.34	neutral	0.84	disease	0.6	disease	0.69	disease	4	1	deleterious	0.4	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	0.53	medium_impact	2.97	high_impact	0.59	0.8	57.37	8.61	0.52	P	0.92	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15296	15296	A	C	MI.9496	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	550	184	I	L	Atc/Ctc	-2.8	0	0	benign	0.12	neutral	0.95	neutral	3.16	neutral	0.66	neutral	0.51	neutral_impact	-0.22	0.96	neutral	0.82	neutral	-0.13	1.54	neutral	0.2	0.45	0.17	neutral	0.15	neutral	0.21	neutral	0.25	neutral	5	0.04	neutral	0.92	deleterious	-6	neutral	0.11	neutral	0.08	medium_impact	0.92	medium_impact	-1.39	low_impact	0.49	0.8	20.53	27.46	0.3	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15296	15296	A	T	MI.9497	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	550	184	I	F	Atc/Ttc	-2.8	0	0	possibly_damaging	0.73	neutral	1	neutral	2.85	neutral	-2.2	neutral	-2.12	medium_impact	2.76	0.94	neutral	0.44	neutral	3.53	23.10	deleterious	0.12	0.4	0.6	disease	0.83	disease	0.5	neutral	0.47	neutral	1	0.73	neutral	0.64	deleterious	0	NA	0.66	deleterious	-1.13	low_impact	1.85	high_impact	1.31	medium_impact	0.42	0.8	20.53	27.46	0.17	N	0.86	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15296	15296	A	G	MI.9498	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	550	184	I	V	Atc/Gtc	-2.8	0	0	benign	0.13	neutral	0.3	neutral	3.09	neutral	0.04	neutral	-0.71	medium_impact	2.1	0.98	neutral	0.89	neutral	0.12	3.80	deleterious	0.3	0.45	0.25	neutral	0.47	neutral	0.38	neutral	0.34	neutral	3	0.65	neutral	0.59	deleterious	-3	neutral	0.15	neutral	0.04	medium_impact	0.02	medium_impact	0.71	medium_impact	0.34	0.8	20.53	27.46	0.4	N	0.50	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15297	15297	T	G	MI.9499	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	551	184	I	S	aTc/aGc	0.64	0.14	0	possibly_damaging	0.87	neutral	0.21	neutral	2.84	deleterious	-3.1	deleterious	-3.57	high_impact	3.73	0.94	neutral	0.43	neutral	4.20	23.90	deleterious	0.04	0.35	0.61	disease	0.81	disease	0.58	disease	0.71	disease	4	0.92	neutral	0.17	neutral	1	deleterious	0.72	deleterious	-1.5	low_impact	-0.09	medium_impact	2.19	high_impact	0.20	0.8	20.53	27.46	0.46	N	0.95	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8569	8569	C	A	MI.95	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	43	15	L	M	Cta/Ata	-2.88	0	0	probably_damaging	1	neutral	0.34	neutral	4.46	neutral	-2.05	neutral	-0.36	low_impact	1.09	0.9	neutral	0.86	neutral	1.72	14.51	neutral	0.38	0.65	0.47	neutral	0.15	neutral	0.4	neutral	0.28	neutral	4	1	deleterious	0.17	neutral	-2	neutral	0.68	deleterious	-3.6	low_impact	0.13	medium_impact	-0.16	medium_impact	0.77	0.9	11.5	26.27	0.48	N	0.11	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8972	8972	T	G	MI.950	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	446	149	L	R	cTa/cGa	-0.1	0	0	probably_damaging	1	neutral	0.24	neutral	4.23	deleterious	-3.52	deleterious	-5.48	medium_impact	3.49	0.75	neutral	0.31	neutral	4.24	23.90	deleterious	0.24	0.65	0.6	disease	0.9	disease	0.63	disease	0.72	disease	4	1	deleterious	0.12	neutral	1	deleterious	0.86	deleterious	-3.6	low_impact	0.01	medium_impact	1.89	medium_impact	0.53	0.9	49.56	8.82	0.33	N	0.99	disease_causing	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15297	15297	T	C	MI.9500	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	551	184	I	T	aTc/aCc	0.64	0.14	0	possibly_damaging	0.83	neutral	0.24	neutral	2.85	neutral	-2.5	deleterious	-2.75	medium_impact	2.65	0.97	neutral	0.68	neutral	3.19	22.70	deleterious	0.08	0.35	0.42	neutral	0.59	disease	0.53	disease	0.49	neutral	0	0.88	neutral	0.21	neutral	0	NA	0.61	deleterious	-1.37	low_impact	-0.05	medium_impact	1.21	medium_impact	0.28	0.8	20.53	27.46	0.46	N	0.95	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15297	15297	T	A	MI.9501	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	551	184	I	N	aTc/aAc	0.64	0.14	0	probably_damaging	0.96	neutral	0.06	neutral	2.82	deleterious	-4.35	deleterious	-4.44	high_impact	4.7	0.92	neutral	0.45	neutral	4.37	24.10	deleterious	0.08	0.35	0.75	disease	0.88	disease	0.61	disease	0.72	disease	4	0.99	deleterious	0.05	neutral	2	deleterious	0.80	deleterious	-2.02	low_impact	-0.43	medium_impact	3.07	high_impact	0.27	0.8	20.53	27.46	0.6	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15298	15298	C	A	MI.9502	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	552	184	I	M	atC/atA	4.54	0.7	0	benign	0.2	neutral	0.12	neutral	2.85	neutral	-2.61	neutral	-0.74	medium_impact	2.28	0.91	neutral	0.54	neutral	3.64	23.20	deleterious	0.2	0.45	0.59	disease	0.57	disease	0.35	neutral	0.21	neutral	6	0.86	neutral	0.46	neutral	-3	neutral	0.22	neutral	-0.17	medium_impact	-0.25	medium_impact	0.88	medium_impact	0.47	0.8	20.53	27.46	0.4	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15298	15298	C	G	MI.9503	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	552	184	I	M	atC/atG	4.54	0.7	0	benign	0.2	neutral	0.12	neutral	2.85	neutral	-2.61	neutral	-0.74	medium_impact	2.28	0.91	neutral	0.54	neutral	3.21	22.70	deleterious	0.2	0.45	0.59	disease	0.57	disease	0.35	neutral	0.21	neutral	6	0.86	neutral	0.46	neutral	-3	neutral	0.22	neutral	-0.17	medium_impact	-0.25	medium_impact	0.88	medium_impact	0.47	0.8	20.53	27.46	0.39	N	0.25	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15299	15299	T	G	MI.9504	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	553	185	L	V	Ttg/Gtg	-6.47	0	0.01	probably_damaging	0.99	neutral	0.21	neutral	2.85	neutral	-2.61	neutral	-2.06	medium_impact	3.27	0.94	neutral	0.47	neutral	3.02	22.30	deleterious	0.23	0.45	0.38	neutral	0.7	disease	0.53	disease	0.57	disease	1	0.99	deleterious	0.11	neutral	1	deleterious	0.73	deleterious	-2.59	low_impact	-0.09	medium_impact	1.78	medium_impact	0.44	0.8	57.89	8.82	0.4	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15299	15299	T	A	MI.9505	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	553	185	L	M	Ttg/Atg	-6.47	0	0.01	probably_damaging	1	neutral	0.12	neutral	2.68	deleterious	-3.6	neutral	-1.29	medium_impact	2.83	0.94	neutral	0.54	neutral	3.47	23.00	deleterious	0.22	0.45	0.53	disease	0.59	disease	0.4	neutral	0.44	neutral	1	1	deleterious	0.06	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	-0.25	medium_impact	1.38	medium_impact	0.50	0.8	57.89	8.82	0.42	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15300	15300	T	G	MI.9506	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	554	185	L	W	tTg/tGg	-0.5	0	0	probably_damaging	1	deleterious	0.03	neutral	2.61	deleterious	-7.2	deleterious	-3.81	high_impact	5.02	0.94	neutral	0.35	neutral	3.76	23.40	deleterious	0.04	0.35	0.87	disease	0.82	disease	0.64	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.83	deleterious	-3.53	low_impact	-0.6	medium_impact	3.36	high_impact	0.22	0.8	57.89	8.82	0.68	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15300	15300	T	C	MI.9507	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	554	185	L	S	tTg/tCg	-0.5	0	0	probably_damaging	1	neutral	0.16	neutral	2.65	deleterious	-4.93	deleterious	-4.13	high_impact	4.82	0.88	neutral	0.47	neutral	3.70	23.30	deleterious	0.02	0.35	0.44	neutral	0.79	disease	0.62	disease	0.65	disease	3	1	deleterious	0.08	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	-0.17	medium_impact	3.18	high_impact	0.46	0.8	57.89	8.82	0.55	P	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15301	15301	G	T	MI.9508	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	555	185	L	F	ttG/ttT	5.69	0.87	0.71	probably_damaging	1	neutral	0.9	neutral	2.72	deleterious	-3.76	neutral	-1.79	medium_impact	1.96	0.94	neutral	0.43	neutral	3.49	23.10	deleterious	0.16	0.45	0.62	disease	0.49	neutral	0.42	neutral	0.49	neutral	0	1	deleterious	0.45	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	0.74	medium_impact	0.59	medium_impact	0.44	0.8	57.89	8.82	0.38	N	0.97	polymorphism	1	0.04	rs193302991	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	15301	15301	G	C	MI.9509	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	555	185	L	F	ttG/ttC	5.69	0.87	0.71	probably_damaging	1	neutral	0.9	neutral	2.72	deleterious	-3.76	neutral	-1.79	medium_impact	1.96	0.94	neutral	0.43	neutral	3.33	22.90	deleterious	0.16	0.45	0.62	disease	0.49	neutral	0.42	neutral	0.49	neutral	0	1	deleterious	0.45	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	0.74	medium_impact	0.59	medium_impact	0.44	0.8	57.89	8.82	0.37	N	0.97	polymorphism	1	0.04	rs193302991	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	8972	8972	T	A	MI.951	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	446	149	L	Q	cTa/cAa	-0.1	0	0	probably_damaging	1	neutral	0.23	neutral	4.24	neutral	-2.82	deleterious	-5.47	medium_impact	2.27	0.87	neutral	0.42	neutral	4.11	23.70	deleterious	0.24	0.65	0.57	disease	0.76	disease	0.5	neutral	0.52	disease	0	1	deleterious	0.12	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.01	medium_impact	0.85	medium_impact	0.58	0.9	49.56	8.82	0.34	N	0.98	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15302	15302	C	G	MI.9510	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	556	186	P	A	Ccc/Gcc	-14.27	0	0	probably_damaging	1	neutral	0.44	neutral	2.62	deleterious	-4.83	deleterious	-6.61	high_impact	4.53	0.94	neutral	0.15	damaging	2.84	21.60	deleterious	0.12	0.4	0.57	disease	0.71	disease	0.69	disease	0.67	disease	3	1	deleterious	0.22	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	0.17	medium_impact	2.92	high_impact	0.68	0.85	58.95	8.72	0.4	N	0.84	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15302	15302	C	A	MI.9511	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	556	186	P	T	Ccc/Acc	-14.27	0	0	probably_damaging	1	neutral	0.34	neutral	2.56	deleterious	-5.94	deleterious	-6.61	high_impact	5.28	0.92	neutral	0.13	damaging	3.63	23.20	deleterious	0.11	0.4	0.64	disease	0.82	disease	0.69	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.07	medium_impact	3.6	high_impact	0.49	0.8	58.95	8.72	0.58	P	0.96	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15302	15302	C	T	MI.9512	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	556	186	P	S	Ccc/Tcc	-14.27	0	0	probably_damaging	1	neutral	0.45	neutral	2.52	deleterious	-5.18	deleterious	-6.61	high_impact	4.66	0.93	neutral	0.1	damaging	3.82	23.40	deleterious	0.09	0.4	0.63	disease	0.86	disease	0.68	disease	0.71	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.18	medium_impact	3.04	high_impact	0.13	0.8	58.95	8.72	0.48	N	0.90	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15303	15303	C	T	MI.9513	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	557	186	P	L	cCc/cTc	5.46	1	0	probably_damaging	1	neutral	1	neutral	2.46	deleterious	-6.93	deleterious	-8.27	high_impact	4.93	0.94	neutral	0.07	damaging	4.40	24.10	deleterious	0.06	0.35	0.47	neutral	0.92	disease	0.67	disease	0.72	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.79	deleterious	-3.53	low_impact	1.85	high_impact	3.28	high_impact	0.64	0.8	58.95	8.72	0.6	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15303	15303	C	G	MI.9514	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	557	186	P	R	cCc/cGc	5.46	1	0	probably_damaging	1	neutral	0.28	neutral	2.44	deleterious	-7.25	deleterious	-7.44	high_impact	5.28	0.93	neutral	0.08	damaging	3.57	23.10	deleterious	0.04	0.35	0.77	disease	0.94	disease	0.77	disease	0.79	disease	6	1	deleterious	0.14	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0	medium_impact	3.6	high_impact	0.30	0.8	58.95	8.72	0.66	P	0.80	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15303	15303	C	A	MI.9515	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	557	186	P	H	cCc/cAc	5.46	1	0	probably_damaging	1	neutral	0.63	neutral	2.43	deleterious	-8.44	deleterious	-7.44	high_impact	5.28	0.91	neutral	0.09	damaging	4.00	23.60	deleterious	0.06	0.35	0.85	disease	0.91	disease	0.78	disease	0.72	disease	4	1	deleterious	0.32	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.35	medium_impact	3.6	high_impact	0.25	0.8	58.95	8.72	0.7	P	0.71	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15305	15305	T	C	MI.9516	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	559	187	F	L	Ttc/Ctc	-3.49	0	0	probably_damaging	0.99	neutral	0.98	neutral	3.17	neutral	-1.2	deleterious	-4.94	medium_impact	3.29	0.97	neutral	0.13	damaging	3.67	23.20	deleterious	0.15	0.4	0.4	neutral	0.82	disease	0.62	disease	0.66	disease	3	0.99	deleterious	0.5	deleterious	1	deleterious	0.75	deleterious	-2.59	low_impact	1.14	medium_impact	1.79	medium_impact	0.52	0.8	58.42	8.64	0.23	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15305	15305	T	A	MI.9517	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	559	187	F	I	Ttc/Atc	-3.49	0	0	probably_damaging	1	neutral	0.49	neutral	3.09	neutral	-2.2	deleterious	-4.95	high_impact	4.54	0.94	neutral	0.12	damaging	4.17	23.80	deleterious	0.11	0.4	0.71	disease	0.86	disease	0.68	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.21	medium_impact	2.93	high_impact	0.43	0.8	58.42	8.64	0.46	N	0.97	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15305	15305	T	G	MI.9518	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	559	187	F	V	Ttc/Gtc	-3.49	0	0	probably_damaging	1	neutral	0.54	neutral	3.11	neutral	-1.89	deleterious	-5.77	high_impact	5.04	0.95	neutral	0.14	damaging	4.04	23.70	deleterious	0.07	0.35	0.68	disease	0.86	disease	0.69	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.26	medium_impact	3.38	high_impact	0.30	0.8	58.42	8.64	0.59	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15306	15306	T	G	MI.9519	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	560	187	F	C	tTc/tGc	7.3	1	0	probably_damaging	1	neutral	0.17	neutral	3	deleterious	-4.76	deleterious	-6.6	high_impact	5.24	0.95	neutral	0.1	damaging	4.07	23.70	deleterious	0.03	0.35	0.91	disease	0.85	disease	0.7	disease	0.68	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.15	medium_impact	3.56	high_impact	0.19	0.8	58.42	8.64	0.7	P	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8972	8972	T	C	MI.952	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	446	149	L	P	cTa/cCa	-0.1	0	0	probably_damaging	1	neutral	0.14	neutral	4.19	deleterious	-4.18	deleterious	-6.42	high_impact	3.84	0.7	neutral	0.38	neutral	3.94	23.50	deleterious	0.18	0.65	0.61	disease	0.87	disease	0.69	disease	0.72	disease	4	1	deleterious	0.07	neutral	2	deleterious	0.85	deleterious	-3.6	low_impact	-0.15	medium_impact	2.19	high_impact	0.51	0.9	49.56	8.82	0.37	N	1.00	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15306	15306	T	C	MI.9520	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	560	187	F	S	tTc/tCc	7.3	1	0	probably_damaging	1	neutral	0.42	neutral	3.04	deleterious	-3	deleterious	-6.6	high_impact	5.24	0.93	neutral	0.09	damaging	4.14	23.80	deleterious	0.03	0.35	0.79	disease	0.82	disease	0.67	disease	0.68	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.15	medium_impact	3.56	high_impact	0.31	0.8	58.42	8.64	0.7	P	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15306	15306	T	A	MI.9521	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	560	187	F	Y	tTc/tAc	7.3	1	0	probably_damaging	0.99	neutral	1	neutral	3.01	deleterious	-3.09	neutral	-2.48	high_impact	5.04	0.95	neutral	0.12	damaging	3.80	23.40	deleterious	0.15	0.4	0.54	disease	0.81	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.51	deleterious	2	deleterious	0.77	deleterious	-2.59	low_impact	1.85	high_impact	3.38	high_impact	0.56	0.8	58.42	8.64	0.71	P	0.87	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15307	15307	C	G	MI.9522	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	561	187	F	L	ttC/ttG	5.69	1	0	probably_damaging	0.99	neutral	0.98	neutral	3.17	neutral	-1.2	deleterious	-4.94	medium_impact	3.29	0.97	neutral	0.13	damaging	3.93	23.50	deleterious	0.15	0.4	0.4	neutral	0.82	disease	0.62	disease	0.66	disease	3	0.99	deleterious	0.5	deleterious	1	deleterious	0.75	deleterious	-2.59	low_impact	1.14	medium_impact	1.79	medium_impact	0.52	0.8	58.42	8.64	0.46	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15307	15307	C	A	MI.9523	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	561	187	F	L	ttC/ttA	5.69	1	0	probably_damaging	0.99	neutral	0.98	neutral	3.17	neutral	-1.2	deleterious	-4.94	medium_impact	3.29	0.97	neutral	0.13	damaging	4.29	24.00	deleterious	0.15	0.4	0.4	neutral	0.82	disease	0.62	disease	0.66	disease	3	0.99	deleterious	0.5	deleterious	1	deleterious	0.75	deleterious	-2.59	low_impact	1.14	medium_impact	1.79	medium_impact	0.52	0.8	58.42	8.64	0.46	N	0.92	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15308	15308	A	T	MI.9524	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	562	188	I	F	Att/Ttt	-5.32	0	0	possibly_damaging	0.66	neutral	0.86	neutral	2.94	neutral	-2.06	deleterious	-2.71	medium_impact	3.36	0.85	neutral	0.41	neutral	2.10	16.86	deleterious	0.13	0.4	0.71	disease	0.82	disease	0.56	disease	0.66	disease	3	0.6	neutral	0.6	deleterious	0	NA	0.67	deleterious	-1	medium_impact	0.65	medium_impact	1.86	medium_impact	0.53	0.8	16.32	15.02	0.18	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15308	15308	A	G	MI.9525	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	562	188	I	V	Att/Gtt	-5.32	0	0	benign	0	neutral	0.44	neutral	3.02	neutral	-1.11	neutral	-0.23	neutral_impact	0.68	0.93	neutral	0.86	neutral	-0.11	1.66	neutral	0.34	0.5	0.27	neutral	0.17	neutral	0.31	neutral	0.27	neutral	5	0.56	neutral	0.72	deleterious	-6	neutral	0.11	neutral	2.07	high_impact	0.17	medium_impact	-0.58	medium_impact	0.38	0.8	16.32	15.02	0.42	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15308	15308	A	C	MI.9526	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	562	188	I	L	Att/Ctt	-5.32	0	0	benign	0.08	neutral	1	neutral	3.35	neutral	0.65	neutral	-0.86	low_impact	0.91	0.9	neutral	0.45	neutral	1.84	15.22	deleterious	0.2	0.45	0.45	neutral	0.55	disease	0.29	neutral	0.25	neutral	5	0.08	neutral	0.96	deleterious	-6	neutral	0.19	neutral	0.26	medium_impact	1.85	high_impact	-0.37	medium_impact	0.57	0.8	16.32	15.02	0.25	N	0.88	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15309	15309	T	A	MI.9527	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	563	188	I	N	aTt/aAt	-0.96	0	0	probably_damaging	0.95	neutral	0.06	neutral	2.88	deleterious	-4.2	deleterious	-4.71	high_impact	4.5	0.83	neutral	0.41	neutral	4.18	23.80	deleterious	0.08	0.35	0.84	disease	0.84	disease	0.54	disease	0.67	disease	3	0.99	deleterious	0.06	neutral	2	deleterious	0.79	deleterious	-1.92	low_impact	-0.43	medium_impact	2.89	high_impact	0.40	0.8	16.32	15.02	0.48	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15309	15309	T	G	MI.9528	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	563	188	I	S	aTt/aGt	-0.96	0	0	possibly_damaging	0.81	neutral	0.07	neutral	2.91	neutral	-2.95	deleterious	-3.83	high_impact	4.5	0.84	neutral	0.39	neutral	3.95	23.60	deleterious	0.03	0.35	0.73	disease	0.8	disease	0.53	disease	0.66	disease	3	0.96	neutral	0.13	neutral	1	deleterious	0.67	deleterious	-1.32	low_impact	-0.39	medium_impact	2.89	high_impact	0.30	0.8	16.32	15.02	0.45	N	0.98	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15309	15309	T	C	MI.9529	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	563	188	I	T	aTt/aCt	-0.96	0	0	possibly_damaging	0.56	neutral	0.07	neutral	2.92	neutral	-2.59	deleterious	-2.88	medium_impact	3.19	0.81	neutral	0.46	neutral	2.88	21.80	deleterious	0.07	0.35	0.66	disease	0.6	disease	0.47	neutral	0.35	neutral	3	0.93	neutral	0.26	neutral	0	NA	0.51	deleterious	-0.83	medium_impact	-0.39	medium_impact	1.7	medium_impact	0.39	0.8	16.32	15.02	0.36	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8974	8974	C	G	MI.953	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	448	150	L	V	Ctc/Gtc	-6.58	0	0	benign	0.07	neutral	0.25	neutral	4.26	neutral	-0.84	neutral	-1.28	low_impact	1.75	0.91	neutral	0.76	neutral	1.55	13.58	neutral	0.39	0.65	0.51	disease	0.62	disease	0.42	neutral	0.47	neutral	1	0.73	neutral	0.59	deleterious	-6	neutral	0.25	neutral	0.31	medium_impact	0.02	medium_impact	0.4	medium_impact	0.68	0.9	15.93	11.92	0.33	N	0.45	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15310	15310	T	A	MI.9530	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	564	188	I	M	atT/atA	2.25	0.03	0.01	possibly_damaging	0.81	neutral	0.07	neutral	2.92	neutral	-2.43	neutral	-1.41	medium_impact	2.05	0.89	neutral	0.52	neutral	2.22	17.61	deleterious	0.25	0.45	0.69	disease	0.49	neutral	0.33	neutral	0.45	neutral	1	0.96	neutral	0.13	neutral	0	NA	0.58	deleterious	-1.32	low_impact	-0.39	medium_impact	0.67	medium_impact	0.47	0.8	16.32	15.02	0.47	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15310	15310	T	G	MI.9531	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	564	188	I	M	atT/atG	2.25	0.03	0.01	possibly_damaging	0.81	neutral	0.07	neutral	2.92	neutral	-2.43	neutral	-1.41	medium_impact	2.05	0.89	neutral	0.52	neutral	1.89	15.56	deleterious	0.25	0.45	0.69	disease	0.49	neutral	0.33	neutral	0.45	neutral	1	0.96	neutral	0.13	neutral	0	NA	0.58	deleterious	-1.32	low_impact	-0.39	medium_impact	0.67	medium_impact	0.47	0.8	16.32	15.02	0.48	N	0.83	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15311	15311	A	C	MI.9532	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	565	189	I	L	Att/Ctt	-6.93	0	0	benign	0.23	neutral	1	neutral	3.1	neutral	-0.17	neutral	-1.52	low_impact	1.8	0.94	neutral	0.43	neutral	2.04	16.44	deleterious	0.19	0.45	0.22	neutral	0.71	disease	0.31	neutral	0.35	neutral	3	0.23	neutral	0.89	deleterious	-6	neutral	0.19	neutral	-0.24	medium_impact	1.85	high_impact	0.44	medium_impact	0.33	0.8	27.89	11.64	0.23	N	0.88	polymorphism	1	0.02	rs35070048	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15311	15311	A	T	MI.9533	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	565	189	I	F	Att/Ttt	-6.93	0	0	possibly_damaging	0.84	neutral	0.4	neutral	2.77	deleterious	-3.19	deleterious	-3.23	high_impact	4.87	0.95	neutral	0.43	neutral	3.54	23.10	deleterious	0.11	0.4	0.63	disease	0.85	disease	0.59	disease	0.68	disease	4	0.84	neutral	0.28	neutral	1	deleterious	0.74	deleterious	-1.4	low_impact	0.13	medium_impact	3.23	high_impact	0.41	0.8	27.89	11.64	0.67	P	0.97	polymorphism	1	0.06	rs35070048	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15311	15311	A	G	MI.9534	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	565	189	I	V	Att/Gtt	-6.93	0	0	benign	0.1	neutral	0.49	neutral	2.89	neutral	-1.52	neutral	-0.61	low_impact	1.57	0.97	neutral	0.95	neutral	-0.02	2.42	deleterious	0.23	0.45	0.36	neutral	0.26	neutral	0.35	neutral	0.4	neutral	2	0.44	neutral	0.7	deleterious	-6	neutral	0.16	neutral	0.16	medium_impact	0.21	medium_impact	0.23	medium_impact	0.32	0.8	27.89	11.64	0.32	N	0.83	polymorphism	1	0.01	rs35070048	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15312	15312	T	G	MI.9535	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	566	189	I	S	aTt/aGt	0.41	0.06	0	probably_damaging	0.93	neutral	0.16	neutral	2.78	deleterious	-3.42	deleterious	-4.75	high_impact	4.12	0.94	neutral	0.43	neutral	4.19	23.80	deleterious	0.03	0.35	0.68	disease	0.84	disease	0.57	disease	0.66	disease	3	0.96	neutral	0.12	neutral	2	deleterious	0.73	deleterious	-1.78	low_impact	-0.17	medium_impact	2.55	high_impact	0.20	0.8	27.89	11.64	0.47	N	0.98	polymorphism	1	0.09	.	.	.	.	.	thyroid tumor	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15312	15312	T	A	MI.9536	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	566	189	I	N	aTt/aAt	0.41	0.06	0	probably_damaging	0.97	neutral	0.05	neutral	2.74	deleterious	-4.71	deleterious	-5.58	high_impact	4.32	0.93	neutral	0.44	neutral	4.23	23.90	deleterious	0.07	0.35	0.81	disease	0.86	disease	0.57	disease	0.68	disease	4	0.99	deleterious	0.04	neutral	2	deleterious	0.80	deleterious	-2.14	low_impact	-0.47	medium_impact	2.73	high_impact	0.23	0.8	27.89	11.64	0.51	N	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15312	15312	T	C	MI.9537	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	566	189	I	T	aTt/aCt	0.41	0.06	0	benign	0.38	neutral	0.07	neutral	2.78	neutral	-2.22	deleterious	-3.82	high_impact	3.55	0.96	neutral	0.55	neutral	3.25	22.80	deleterious	0.06	0.35	0.61	disease	0.69	disease	0.51	disease	0.46	neutral	1	0.92	neutral	0.35	neutral	-2	neutral	0.30	neutral	-0.53	medium_impact	-0.39	medium_impact	2.03	high_impact	0.18	0.8	27.89	11.64	0.43	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15313	15313	T	A	MI.9538	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	567	189	I	M	atT/atA	7.3	0.95	0	probably_damaging	0.92	neutral	0.37	neutral	2.78	neutral	-2.59	neutral	-2.26	medium_impact	2.6	0.95	neutral	0.44	neutral	3.55	23.10	deleterious	0.19	0.45	0.62	disease	0.69	disease	0.48	neutral	0.45	neutral	1	0.92	neutral	0.23	neutral	1	deleterious	0.65	deleterious	-1.72	low_impact	0.1	medium_impact	1.17	medium_impact	0.36	0.8	27.89	11.64	0.5	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15313	15313	T	G	MI.9539	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	567	189	I	M	atT/atG	7.3	0.95	0	probably_damaging	0.92	neutral	0.37	neutral	2.78	neutral	-2.59	neutral	-2.26	medium_impact	2.6	0.95	neutral	0.44	neutral	3.27	22.80	deleterious	0.19	0.45	0.62	disease	0.69	disease	0.48	neutral	0.45	neutral	1	0.92	neutral	0.23	neutral	1	deleterious	0.65	deleterious	-1.72	low_impact	0.1	medium_impact	1.17	medium_impact	0.36	0.8	27.89	11.64	0.5	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8974	8974	C	A	MI.954	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	448	150	L	I	Ctc/Atc	-6.58	0	0	benign	0.07	neutral	0.57	neutral	4.24	neutral	-1.06	neutral	-0.39	low_impact	1.15	0.89	neutral	0.76	neutral	2.21	17.56	deleterious	0.32	0.65	0.4	neutral	0.49	neutral	0.32	neutral	0.47	neutral	1	0.36	neutral	0.75	deleterious	-6	neutral	0.22	neutral	0.31	medium_impact	0.36	medium_impact	-0.11	medium_impact	0.75	0.9	15.93	11.92	0.27	N	0.32	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15314	15314	G	T	MI.9540	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	568	190	A	S	Gca/Tca	-3.03	0	0.03	benign	0.2	neutral	0.18	neutral	3.07	neutral	-2.12	neutral	-1.67	low_impact	1.25	0.97	neutral	0.95	neutral	1.88	15.48	deleterious	0.21	0.45	0.39	neutral	0.61	disease	0.28	neutral	0.4	neutral	2	0.79	neutral	0.49	deleterious	-6	neutral	0.19	neutral	-0.17	medium_impact	-0.14	medium_impact	-0.06	medium_impact	0.38	0.8	13.42	16.99	0.46	N	0.44	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15314	15314	G	C	MI.9541	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	568	190	A	P	Gca/Cca	-3.03	0	0.03	possibly_damaging	0.58	neutral	0.28	neutral	3.02	deleterious	-3.78	deleterious	-3.02	high_impact	4.09	0.98	neutral	0.32	neutral	3.65	23.20	deleterious	0.06	0.35	0.65	disease	0.92	disease	0.56	disease	0.71	disease	4	0.72	neutral	0.35	neutral	1	deleterious	0.56	deleterious	-0.86	medium_impact	0	medium_impact	2.52	high_impact	0.46	0.8	13.42	16.99	0.44	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15314	15314	G	A	MI.9542	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	568	190	A	T	Gca/Aca	-3.03	0	0.03	benign	0	neutral	0.22	neutral	3.07	neutral	-0.99	neutral	-1.68	low_impact	1.12	0.99	neutral	0.97	neutral	2.02	16.36	deleterious	0.15	0.4	0.27	neutral	0.45	neutral	0.28	neutral	0.46	neutral	1	0.78	neutral	0.61	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	-0.08	medium_impact	-0.18	medium_impact	0.79	0.85	13.42	16.99	0.56	P	0.02	polymorphism	1	0.02	rs527236176	Likely_pathogenic	Neoplasm_of_ovary	153604	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	21.69	.	.	.	.	.	.	P	.	P	neutral
chrM	15315	15315	C	A	MI.9543	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	569	190	A	E	gCa/gAa	-3.03	0	0	possibly_damaging	0.47	neutral	0.11	neutral	3.03	deleterious	-3.44	deleterious	-2.99	high_impact	4.43	0.93	neutral	0.44	neutral	4.25	23.90	deleterious	0.05	0.35	0.52	disease	0.9	disease	0.58	disease	0.71	disease	4	0.88	neutral	0.32	neutral	1	deleterious	0.47	deleterious	-0.68	medium_impact	-0.27	medium_impact	2.83	high_impact	0.47	0.8	13.42	16.99	0.5	N	0.49	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15315	15315	C	G	MI.9544	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	569	190	A	G	gCa/gGa	-3.03	0	0	benign	0.08	neutral	0.26	neutral	3.15	neutral	-1.38	deleterious	-2.81	high_impact	3.75	0.93	neutral	0.5	neutral	2.25	17.85	deleterious	0.16	0.45	0.59	disease	0.79	disease	0.47	neutral	0.63	disease	3	0.71	neutral	0.59	deleterious	-2	neutral	0.23	neutral	0.26	medium_impact	-0.02	medium_impact	2.21	high_impact	0.68	0.85	13.42	16.99	0.37	N	0.40	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15315	15315	C	T	MI.9545	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	569	190	A	V	gCa/gTa	-3.03	0	0	benign	0.13	neutral	0.7	neutral	3.18	neutral	-0.15	neutral	-1.17	low_impact	1.07	0.97	neutral	0.82	neutral	2.61	20.20	deleterious	0.16	0.45	0.24	neutral	0.7	disease	0.28	neutral	0.42	neutral	2	0.18	neutral	0.79	deleterious	-6	neutral	0.22	neutral	0.04	medium_impact	0.42	medium_impact	-0.22	medium_impact	0.73	0.85	13.42	16.99	0.29	N	0.23	polymorphism	1	0.01	rs879191792	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15317	15317	G	C	MI.9546	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	571	191	A	P	Gcc/Ccc	-2.11	0	0	possibly_damaging	0.76	neutral	0.18	neutral	2.92	deleterious	-4.22	deleterious	-3.07	high_impact	4.05	0.94	neutral	0.27	damaging	3.74	23.30	deleterious	0.03	0.35	0.71	disease	0.94	disease	0.68	disease	0.76	disease	5	0.87	neutral	0.21	neutral	1	deleterious	0.77	deleterious	-1.2	low_impact	-0.14	medium_impact	2.48	high_impact	0.55	0.8	23.68	8.7	0.42	N	0.98	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15317	15317	G	T	MI.9547	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	571	191	A	S	Gcc/Tcc	-2.11	0	0	benign	0.36	neutral	0.22	neutral	2.97	neutral	-2.06	neutral	-1.4	medium_impact	2.44	0.96	neutral	0.48	neutral	3.36	22.90	deleterious	0.2	0.45	0.47	neutral	0.81	disease	0.45	neutral	0.58	disease	2	0.74	neutral	0.43	neutral	-3	neutral	0.30	neutral	-0.5	medium_impact	-0.08	medium_impact	1.02	medium_impact	0.48	0.8	23.68	8.7	0.37	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15317	15317	G	A	MI.9548	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	571	191	A	T	Gcc/Acc	-2.11	0	0	benign	0.02	neutral	0.3	neutral	2.98	neutral	-1.88	neutral	-2.5	medium_impact	3.02	0.98	neutral	0.63	neutral	3.88	23.50	deleterious	0.1	0.4	0.47	neutral	0.79	disease	0.48	neutral	0.54	disease	1	0.69	neutral	0.64	deleterious	-3	neutral	0.19	neutral	0.85	medium_impact	0.02	medium_impact	1.55	medium_impact	0.58	0.8	23.68	8.7	0.4	N	0.79	polymorphism	1	0.04	rs2853507	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15318	15318	C	T	MI.9549	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	572	191	A	V	gCc/gTc	5.92	1	0	benign	0.26	neutral	0.43	neutral	3.12	neutral	-0.4	deleterious	-2.91	medium_impact	2.42	0.95	neutral	0.51	neutral	4.11	23.70	deleterious	0.09	0.35	0.33	neutral	0.88	disease	0.39	neutral	0.69	disease	4	0.48	neutral	0.59	deleterious	-3	neutral	0.46	deleterious	-0.31	medium_impact	0.16	medium_impact	1	medium_impact	0.56	0.8	23.68	8.7	0.54	N	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8974	8974	C	T	MI.955	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	448	150	L	F	Ctc/Ttc	-6.58	0	0	benign	0	neutral	0.79	neutral	4.45	neutral	0.25	neutral	2.75	neutral_impact	-0.18	0.85	neutral	0.98	neutral	-0.64	0.10	neutral	0.36	0.65	0.26	neutral	0.12	neutral	0.28	neutral	0.25	neutral	5	0.2	neutral	0.9	deleterious	-6	neutral	0.15	neutral	2.09	high_impact	0.62	medium_impact	-1.25	low_impact	0.59	0.9	15.93	11.92	0.29	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15318	15318	C	A	MI.9550	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	572	191	A	D	gCc/gAc	5.92	1	0	possibly_damaging	0.69	neutral	0.1	neutral	2.91	deleterious	-4.71	deleterious	-3.2	high_impact	4.86	0.9	neutral	0.37	neutral	4.52	24.30	deleterious	0.03	0.35	0.63	disease	0.95	disease	0.67	disease	0.79	disease	6	0.91	neutral	0.21	neutral	1	deleterious	0.72	deleterious	-1.06	low_impact	-0.3	medium_impact	3.22	high_impact	0.35	0.8	23.68	8.7	0.68	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15318	15318	C	G	MI.9551	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	572	191	A	G	gCc/gGc	5.92	1	0	benign	0.17	neutral	0.27	neutral	3	neutral	-1.66	neutral	0.06	neutral_impact	0.39	0.96	neutral	0.53	neutral	0.98	10.53	neutral	0.16	0.45	0.29	neutral	0.38	neutral	0.29	neutral	0.4	neutral	2	0.68	neutral	0.55	deleterious	-6	neutral	0.21	neutral	-0.09	medium_impact	-0.01	medium_impact	-0.84	medium_impact	0.62	0.8	23.68	8.7	0.6	P	0.83	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15320	15320	C	G	MI.9552	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	574	192	L	V	Cta/Gta	-11.28	0	0	possibly_damaging	0.57	neutral	0.6	neutral	2.77	deleterious	-5.3	neutral	-0.57	low_impact	1.15	0.96	neutral	0.58	neutral	2.06	16.61	deleterious	0.33	0.5	0.39	neutral	0.39	neutral	0.36	neutral	0.46	neutral	1	0.51	neutral	0.52	deleterious	-3	neutral	0.42	neutral	-0.85	medium_impact	0.32	medium_impact	-0.15	medium_impact	0.48	0.8	16.32	15.77	0.29	N	0.57	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15320	15320	C	A	MI.9553	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	574	192	L	M	Cta/Ata	-11.28	0	0	probably_damaging	0.94	neutral	0.29	neutral	2.68	deleterious	-5.97	neutral	-0.26	neutral_impact	0.63	0.93	neutral	0.75	neutral	2.39	18.77	deleterious	0.27	0.45	0.43	neutral	0.19	neutral	0.27	neutral	0.37	neutral	3	0.95	neutral	0.18	neutral	-2	neutral	0.65	deleterious	-1.85	low_impact	0.01	medium_impact	-0.62	medium_impact	0.50	0.8	16.32	15.77	0.47	N	0.64	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15321	15321	T	A	MI.9554	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	575	192	L	Q	cTa/cAa	-2.57	0	0	probably_damaging	0.92	neutral	0.31	neutral	2.61	deleterious	-8.09	neutral	-2.37	high_impact	4.58	0.94	neutral	0.44	neutral	4.00	23.60	deleterious	0.03	0.35	0.72	disease	0.74	disease	0.56	disease	0.68	disease	4	0.93	neutral	0.2	neutral	2	deleterious	0.72	deleterious	-1.72	low_impact	0.03	medium_impact	2.97	high_impact	0.25	0.8	16.32	15.77	0.47	N	0.91	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15321	15321	T	G	MI.9555	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	575	192	L	R	cTa/cGa	-2.57	0	0	probably_damaging	0.92	neutral	0.36	neutral	2.61	deleterious	-7.87	deleterious	-2.55	high_impact	4.58	0.94	neutral	0.41	neutral	4.11	23.70	deleterious	0.02	0.35	0.71	disease	0.9	disease	0.69	disease	0.75	disease	5	0.92	neutral	0.22	neutral	2	deleterious	0.81	deleterious	-1.72	low_impact	0.09	medium_impact	2.97	high_impact	0.18	0.8	16.32	15.77	0.45	N	0.99	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15321	15321	T	C	MI.9556	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	575	192	L	P	cTa/cCa	-2.57	0	0	benign	0.03	neutral	0.23	neutral	2.61	deleterious	-8.49	deleterious	-2.94	high_impact	4.24	0.92	neutral	0.34	neutral	3.84	23.40	deleterious	0.02	0.35	0.79	disease	0.88	disease	0.68	disease	0.76	disease	5	0.76	neutral	0.6	deleterious	-2	neutral	0.32	neutral	0.68	medium_impact	-0.06	medium_impact	2.66	high_impact	0.18	0.8	16.32	15.77	0.37	N	0.95	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15323	15323	G	T	MI.9557	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	577	193	A	S	Gca/Tca	-4.86	0	0.07	benign	0.2	neutral	0.41	neutral	3.15	neutral	4.67	neutral	0.36	neutral_impact	-0.44	0.93	neutral	0.54	neutral	1.94	15.85	deleterious	0.25	0.45	0.22	neutral	0.36	neutral	0.21	neutral	0.45	neutral	1	0.51	neutral	0.61	deleterious	-6	neutral	0.17	neutral	-0.17	medium_impact	0.14	medium_impact	-1.59	low_impact	0.59	0.8	22.11	27.24	0.37	N	0.55	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15323	15323	G	C	MI.9558	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	577	193	A	P	Gca/Cca	-4.86	0	0.07	possibly_damaging	0.58	neutral	0.2	neutral	3.09	neutral	-2.13	neutral	-1.45	medium_impact	3.17	0.94	neutral	0.3	neutral	3.67	23.30	deleterious	0.06	0.35	0.65	disease	0.91	disease	0.62	disease	0.78	disease	6	0.8	neutral	0.31	neutral	0	NA	0.66	deleterious	-0.86	medium_impact	-0.1	medium_impact	1.69	medium_impact	0.55	0.8	22.11	27.24	0.35	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15323	15323	G	A	MI.9559	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	577	193	A	T	Gca/Aca	-4.86	0	0.07	benign	0.01	neutral	0.47	neutral	3.16	neutral	-0.81	neutral	2.05	neutral_impact	-0.86	0.98	neutral	0.91	neutral	1.50	13.31	neutral	0.15	0.45	0.27	neutral	0.1	neutral	0.19	neutral	0.28	neutral	5	0.52	neutral	0.73	deleterious	-6	neutral	0.11	neutral	1.13	medium_impact	0.19	medium_impact	-1.97	low_impact	0.68	0.85	22.11	27.24	0.49	N	0.00	polymorphism	1	0.00	rs527236177	Likely_pathogenic	Familial_cancer_of_breast	153605	MedGen:C0346153,OMIM:114480,Orphanet:ORPHA227535,SNOMED_CT:254843006	.	.	.	11.14	.	.	.	.	.	.	P	.	P	neutral
chrM	8975	8975	T	G	MI.956	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	449	150	L	R	cTc/cGc	0.13	0.02	0	possibly_damaging	0.46	deleterious	0	neutral	4.1	deleterious	-4.01	deleterious	-3.47	medium_impact	3.46	0.79	neutral	0.46	neutral	2.57	19.95	deleterious	0.13	0.65	0.82	disease	0.91	disease	0.73	disease	0.81	disease	6	1	deleterious	0.27	neutral	4	deleterious	0.61	deleterious	-0.69	medium_impact	-1.4	low_impact	1.87	medium_impact	0.64	0.9	15.93	11.92	0.32	N	0.79	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15324	15324	C	G	MI.9560	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	578	193	A	G	gCa/gGa	0.18	0	0	benign	0.13	neutral	0.36	neutral	3.13	neutral	-0.96	neutral	-1.83	medium_impact	2.96	0.92	neutral	0.5	neutral	2.21	17.55	deleterious	0.2	0.45	0.56	disease	0.69	disease	0.38	neutral	0.45	neutral	1	0.58	neutral	0.62	deleterious	-3	neutral	0.24	neutral	0.04	medium_impact	0.09	medium_impact	1.49	medium_impact	0.65	0.8	22.11	27.24	0.33	N	0.50	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15324	15324	C	A	MI.9561	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	578	193	A	E	gCa/gAa	0.18	0	0	possibly_damaging	0.6	neutral	0.3	neutral	3.09	neutral	-1.55	neutral	-1.33	medium_impact	3.17	0.93	neutral	0.45	neutral	4.41	24.10	deleterious	0.06	0.35	0.5	disease	0.87	disease	0.62	disease	0.77	disease	5	0.72	neutral	0.35	neutral	0	NA	0.47	deleterious	-0.9	medium_impact	0.02	medium_impact	1.69	medium_impact	0.48	0.8	22.11	27.24	0.34	N	0.73	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15324	15324	C	T	MI.9562	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	578	193	A	V	gCa/gTa	0.18	0	0	benign	0	neutral	0.56	neutral	3.34	neutral	-1.58	neutral	-0.37	neutral_impact	-0.84	0.98	neutral	0.97	neutral	1.35	12.54	neutral	0.13	0.4	0.14	neutral	0.43	neutral	0.26	neutral	0.44	neutral	1	0.43	neutral	0.78	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.28	medium_impact	-1.96	low_impact	0.57	0.8	22.11	27.24	0.36	N	0.03	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15326	15326	A	T	MI.9563	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	580	194	T	S	Aca/Tca	-7.16	0	0.23	benign	0.4	neutral	0.52	neutral	3.13	neutral	-0.38	neutral	-0.52	neutral_impact	0.06	0.93	neutral	0.63	neutral	1.42	12.91	neutral	0.32	0.5	0.21	neutral	0.33	neutral	0.37	neutral	0.44	neutral	1	0.43	neutral	0.56	deleterious	-6	neutral	0.26	neutral	-0.57	medium_impact	0.24	medium_impact	-1.14	low_impact	0.48	0.8	25	20.03	0.32	N	0.23	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15326	15326	A	G	MI.9564	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	580	194	T	A	Aca/Gca	-7.16	0	0.23	benign	0.02	neutral	0.49	neutral	3.23	neutral	0.41	neutral	0.31	neutral_impact	-1.01	0.99	neutral	0.98	neutral	0.10	3.59	deleterious	0.24	0.45	0.29	neutral	0.21	neutral	0.26	neutral	0.35	neutral	3	0.49	neutral	0.74	deleterious	-6	neutral	0.12	neutral	0.85	medium_impact	0.21	medium_impact	-2.11	low_impact	0.28	0.8	25	20.03	0.4	N	0.16	polymorphism	1	0.00	rs2853508	Likely_pathogenic	Familial_cancer_of_breast	150284	MedGen:C0346153,OMIM:114480,Orphanet:ORPHA227535,SNOMED_CT:254843006	.	.	.	16.34	.	.	.	.	.	.	P	.	P	neutral
chrM	15326	15326	A	C	MI.9565	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	580	194	T	P	Aca/Cca	-7.16	0	0.23	possibly_damaging	0.79	neutral	0.15	neutral	3.07	neutral	-1.32	neutral	-1.4	low_impact	1.59	0.93	neutral	0.45	neutral	1.53	13.46	neutral	0.07	0.35	0.41	neutral	0.81	disease	0.62	disease	0.76	disease	5	0.9	neutral	0.18	neutral	-3	neutral	0.59	deleterious	-1.27	low_impact	-0.19	medium_impact	0.25	medium_impact	0.30	0.8	25	20.03	0.37	N	0.80	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15327	15327	C	T	MI.9566	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	581	194	T	M	aCa/aTa	-5.55	0	0	probably_damaging	0.94	neutral	0.42	neutral	3.16	neutral	1.19	neutral	2.13	neutral_impact	-2.42	0.93	neutral	0.93	neutral	-0.74	0.06	neutral	0.15	0.4	0.2	neutral	0.11	neutral	0.22	neutral	0.24	neutral	5	0.94	neutral	0.24	neutral	-2	neutral	0.58	deleterious	-1.85	low_impact	0.15	medium_impact	-3.39	low_impact	0.49	0.8	25	20.03	0.36	N	0.02	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15327	15327	C	A	MI.9567	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	581	194	T	K	aCa/aAa	-5.55	0	0	possibly_damaging	0.52	neutral	0.33	neutral	3.06	neutral	-0.61	neutral	-1.02	low_impact	1.59	0.94	neutral	0.55	neutral	2.51	19.50	deleterious	0.11	0.4	0.32	neutral	0.68	disease	0.52	disease	0.57	disease	1	0.66	neutral	0.41	neutral	-3	neutral	0.44	deleterious	-0.76	medium_impact	0.06	medium_impact	0.25	medium_impact	0.48	0.8	25	20.03	0.34	N	0.74	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15329	15329	C	T	MI.9568	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	583	195	L	F	Ctc/Ttc	-8.99	0	0	probably_damaging	1	neutral	0.74	neutral	3.08	neutral	-2.28	neutral	-2.29	medium_impact	2.69	0.94	neutral	0.67	neutral	3.87	23.50	deleterious	0.23	0.45	0.37	neutral	0.68	disease	0.56	disease	0.68	disease	4	1	deleterious	0.37	neutral	1	deleterious	0.73	deleterious	-3.53	low_impact	0.47	medium_impact	1.25	medium_impact	0.48	0.8	22.37	27.75	0.26	N	0.47	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15329	15329	C	G	MI.9569	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	583	195	L	V	Ctc/Gtc	-8.99	0	0	probably_damaging	1	neutral	0.66	neutral	3.12	neutral	0.51	neutral	-0.07	neutral_impact	0.4	0.97	neutral	0.94	neutral	0.51	7.50	deleterious	0.26	0.45	0.2	neutral	0.09	neutral	0.29	neutral	0.29	neutral	4	1	deleterious	0.33	neutral	-2	neutral	0.64	deleterious	-3.53	low_impact	0.38	medium_impact	-0.83	medium_impact	0.57	0.8	22.37	27.75	0.37	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8975	8975	T	C	MI.957	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	449	150	L	P	cTc/cCc	0.13	0.02	0	possibly_damaging	0.64	deleterious	0	neutral	4.09	deleterious	-4.57	deleterious	-4.38	medium_impact	3.46	0.8	neutral	0.39	neutral	3.67	23.30	deleterious	0.15	0.65	0.86	disease	0.92	disease	0.73	disease	0.82	disease	6	1	deleterious	0.18	neutral	4	deleterious	0.73	deleterious	-0.99	medium_impact	-1.4	low_impact	1.87	medium_impact	0.61	0.9	15.93	11.92	0.36	N	0.95	disease_causing	0.98	0.26	rs1981459	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15329	15329	C	A	MI.9570	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	583	195	L	I	Ctc/Atc	-8.99	0	0	probably_damaging	1	neutral	0.74	neutral	3.14	neutral	3.77	neutral	0.22	neutral_impact	-0.26	0.94	neutral	0.94	neutral	2.23	17.68	deleterious	0.31	0.45	0.15	neutral	0.12	neutral	0.22	neutral	0.28	neutral	4	1	deleterious	0.37	neutral	-2	neutral	0.65	deleterious	-3.53	low_impact	0.47	medium_impact	-1.43	low_impact	0.43	0.8	22.37	27.75	0.33	N	0.21	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15330	15330	T	G	MI.9571	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	584	195	L	R	cTc/cGc	-0.96	0	0	probably_damaging	1	neutral	0.28	neutral	2.93	deleterious	-3.62	deleterious	-4.09	high_impact	4.42	0.94	neutral	0.52	neutral	4.13	23.80	deleterious	0.02	0.35	0.64	disease	0.9	disease	0.68	disease	0.77	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0	medium_impact	2.82	high_impact	0.17	0.8	22.37	27.75	0.52	N	0.87	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15330	15330	T	A	MI.9572	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	584	195	L	H	cTc/cAc	-0.96	0	0	probably_damaging	1	neutral	0.7	neutral	2.92	deleterious	-4.6	deleterious	-4.46	high_impact	4.08	0.93	neutral	0.54	neutral	4.28	24.00	deleterious	0.05	0.35	0.71	disease	0.75	disease	0.65	disease	0.71	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.42	medium_impact	2.51	high_impact	0.24	0.8	22.37	27.75	0.31	N	0.80	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15330	15330	T	C	MI.9573	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	584	195	L	P	cTc/cCc	-0.96	0	0	probably_damaging	1	neutral	0.17	neutral	2.93	deleterious	-4.06	deleterious	-4.21	high_impact	4.08	0.93	neutral	0.42	neutral	3.89	23.50	deleterious	0.02	0.35	0.71	disease	0.89	disease	0.69	disease	0.77	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.15	medium_impact	2.51	high_impact	0.27	0.8	22.37	27.75	0.46	N	0.93	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15332	15332	C	G	MI.9574	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	586	196	H	D	Cac/Gac	-12.66	0	0	probably_damaging	1	neutral	0.21	neutral	2.27	deleterious	-7.01	deleterious	-7.42	high_impact	5.64	0.84	neutral	0.11	damaging	3.70	23.30	deleterious	0.05	0.35	0.7	disease	0.88	disease	0.81	disease	0.75	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.09	medium_impact	3.93	high_impact	0.24	0.8	58.42	8.76	0.61	P	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15332	15332	C	A	MI.9575	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	586	196	H	N	Cac/Aac	-12.66	0	0	probably_damaging	1	neutral	0.31	neutral	2.27	deleterious	-7.34	deleterious	-5.77	high_impact	5.29	0.86	neutral	0.13	damaging	3.57	23.10	deleterious	0.16	0.45	0.46	neutral	0.86	disease	0.75	disease	0.72	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.03	medium_impact	3.61	high_impact	0.31	0.8	58.42	8.76	0.63	P	0.97	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15332	15332	C	T	MI.9576	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	586	196	H	Y	Cac/Tac	-12.66	0	0	probably_damaging	1	neutral	1	neutral	2.24	deleterious	-6.87	deleterious	-4.94	high_impact	5.09	0.87	neutral	0.13	damaging	3.38	23.00	deleterious	0.1	0.4	0.59	disease	0.89	disease	0.77	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.84	deleterious	-3.53	low_impact	1.85	high_impact	3.43	high_impact	0.20	0.8	58.42	8.76	0.63	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15333	15333	A	C	MI.9577	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	587	196	H	P	cAc/cCc	5.46	1	0	probably_damaging	1	neutral	0.21	neutral	2.24	deleterious	-8.14	deleterious	-8.24	high_impact	4.95	0.88	neutral	0.08	damaging	3.53	23.10	deleterious	0.04	0.35	0.82	disease	0.9	disease	0.84	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.09	medium_impact	3.3	high_impact	0.20	0.8	58.42	8.76	0.65	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15333	15333	A	T	MI.9578	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	587	196	H	L	cAc/cTc	5.46	1	0	probably_damaging	1	neutral	0.66	neutral	2.26	deleterious	-7.23	deleterious	-9.06	high_impact	5.64	0.88	neutral	0.11	damaging	4.03	23.70	deleterious	0.04	0.35	0.62	disease	0.93	disease	0.75	disease	0.74	disease	5	1	deleterious	0.33	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.38	medium_impact	3.93	high_impact	0.14	0.8	58.42	8.76	0.67	P	0.92	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15333	15333	A	G	MI.9579	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	587	196	H	R	cAc/cGc	5.46	1	0	probably_damaging	1	neutral	0.35	neutral	2.3	deleterious	-6.87	deleterious	-6.59	high_impact	5.29	0.87	neutral	0.09	damaging	3.18	22.70	deleterious	0.06	0.35	0.65	disease	0.9	disease	0.8	disease	0.75	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.08	medium_impact	3.61	high_impact	0.26	0.8	58.42	8.76	0.71	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8975	8975	T	A	MI.958	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	449	150	L	H	cTc/cAc	0.13	0.02	0	possibly_damaging	0.63	deleterious	0	neutral	4.09	deleterious	-4.57	neutral	-2.46	medium_impact	3.46	0.81	neutral	0.5	neutral	3.94	23.50	deleterious	0.17	0.65	0.86	disease	0.8	disease	0.7	disease	0.78	disease	6	1	deleterious	0.19	neutral	4	deleterious	0.60	deleterious	-0.98	medium_impact	-1.4	low_impact	1.87	medium_impact	0.64	0.9	15.93	11.92	0.31	N	0.71	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15334	15334	C	G	MI.9580	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	588	196	H	Q	caC/caG	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	2.3	deleterious	-7.37	deleterious	-6.59	high_impact	5.09	0.91	neutral	0.12	damaging	3.27	22.80	deleterious	0.1	0.4	0.67	disease	0.86	disease	0.76	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.02	medium_impact	3.43	high_impact	0.39	0.8	58.42	8.76	0.7	P	0.94	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15334	15334	C	A	MI.9581	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	588	196	H	Q	caC/caA	8.44	1	0	probably_damaging	1	neutral	0.3	neutral	2.3	deleterious	-7.37	deleterious	-6.59	high_impact	5.09	0.91	neutral	0.12	damaging	3.60	23.20	deleterious	0.1	0.4	0.67	disease	0.86	disease	0.76	disease	0.73	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.02	medium_impact	3.43	high_impact	0.39	0.8	58.42	8.76	0.71	P	0.94	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15335	15335	C	T	MI.9582	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	589	197	L	F	Ctc/Ttc	-1.19	0	0	benign	0.01	neutral	0.72	neutral	3.03	deleterious	-6.13	deleterious	-3.18	high_impact	4.49	0.95	neutral	0.49	neutral	3.75	23.30	deleterious	0.11	0.4	0.73	disease	0.74	disease	0.41	neutral	0.47	neutral	1	0.25	neutral	0.86	deleterious	-2	neutral	0.29	neutral	1.13	medium_impact	0.44	medium_impact	2.88	high_impact	0.39	0.8	58.68	8.52	0.35	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15335	15335	C	A	MI.9583	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	589	197	L	I	Ctc/Atc	-1.19	0	0	benign	0.2	neutral	0.44	neutral	2.98	deleterious	-5.02	neutral	-1.56	medium_impact	2.22	0.94	neutral	0.46	neutral	3.91	23.50	deleterious	0.23	0.45	0.39	neutral	0.68	disease	0.34	neutral	0.4	neutral	2	0.47	neutral	0.62	deleterious	-3	neutral	0.28	neutral	-0.17	medium_impact	0.17	medium_impact	0.82	medium_impact	0.54	0.8	58.68	8.52	0.33	N	0.86	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15335	15335	C	G	MI.9584	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	589	197	L	V	Ctc/Gtc	-1.19	0	0	benign	0.08	neutral	0.54	neutral	3.03	deleterious	-5.3	neutral	-2.33	medium_impact	3.35	0.95	neutral	0.47	neutral	1.72	14.54	neutral	0.19	0.45	0.61	disease	0.64	disease	0.5	neutral	0.48	neutral	0	0.38	neutral	0.73	deleterious	-3	neutral	0.28	neutral	0.26	medium_impact	0.26	medium_impact	1.85	medium_impact	0.50	0.8	58.68	8.52	0.25	N	0.91	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15336	15336	T	C	MI.9585	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	590	197	L	P	cTc/cCc	-0.73	0	0	possibly_damaging	0.9	neutral	0.21	neutral	2.84	deleterious	-8.49	deleterious	-5.55	high_impact	4.66	0.93	neutral	0.29	neutral	3.87	23.50	deleterious	0.01	0.35	0.93	disease	0.86	disease	0.72	disease	0.76	disease	5	0.94	neutral	0.16	neutral	1	deleterious	0.84	deleterious	-1.62	low_impact	-0.09	medium_impact	3.04	high_impact	0.28	0.8	58.68	8.52	0.55	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15336	15336	T	G	MI.9586	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	590	197	L	R	cTc/cGc	-0.73	0	0	benign	0.41	neutral	0.34	neutral	2.84	deleterious	-7.87	deleterious	-4.76	high_impact	5.46	0.94	neutral	0.33	neutral	4.15	23.80	deleterious	0.01	0.35	0.89	disease	0.9	disease	0.71	disease	0.75	disease	5	0.61	neutral	0.47	neutral	-2	neutral	0.66	deleterious	-0.58	medium_impact	0.07	medium_impact	3.76	high_impact	0.19	0.8	58.68	8.52	0.6	P	0.99	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15336	15336	T	A	MI.9587	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	590	197	L	H	cTc/cAc	-0.73	0	0	possibly_damaging	0.81	neutral	0.67	neutral	2.83	deleterious	-8.81	deleterious	-5.57	high_impact	5.46	0.93	neutral	0.33	neutral	4.10	23.70	deleterious	0.03	0.35	0.93	disease	0.85	disease	0.66	disease	0.77	disease	5	0.78	neutral	0.43	neutral	1	deleterious	0.75	deleterious	-1.32	low_impact	0.39	medium_impact	3.76	high_impact	0.29	0.8	58.68	8.52	0.59	P	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15338	15338	C	G	MI.9588	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	592	198	L	V	Cta/Gta	-10.6	0	0	probably_damaging	0.98	neutral	0.46	neutral	3.04	deleterious	-5.3	neutral	-1.88	medium_impact	2.56	0.95	neutral	0.11	damaging	1.73	14.61	neutral	0.27	0.45	0.34	neutral	0.58	disease	0.37	neutral	0.44	neutral	1	0.98	neutral	0.24	neutral	1	deleterious	0.70	deleterious	-2.31	low_impact	0.18	medium_impact	1.13	medium_impact	0.54	0.8	47.37	9.09	0.28	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15338	15338	C	A	MI.9589	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	592	198	L	M	Cta/Ata	-10.6	0	0	probably_damaging	1	neutral	0.24	neutral	3.05	deleterious	-5.97	neutral	-1.34	low_impact	1.86	0.94	neutral	0.11	damaging	3.61	23.20	deleterious	0.24	0.45	0.47	neutral	0.58	disease	0.34	neutral	0.4	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.71	deleterious	-3.53	low_impact	-0.05	medium_impact	0.5	medium_impact	0.47	0.8	47.37	9.09	0.35	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8977	8977	A	T	MI.959	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	451	151	I	F	Att/Ttt	-3.34	0	0	probably_damaging	0.99	deleterious	0	neutral	4.28	neutral	-2	deleterious	-3.61	medium_impact	2.63	0.77	neutral	0.46	neutral	3.81	23.40	deleterious	0.38	0.65	0.28	neutral	0.84	disease	0.68	disease	0.72	disease	4	1	deleterious	0.01	neutral	5	deleterious	0.76	deleterious	-2.65	low_impact	-1.4	low_impact	1.16	medium_impact	0.81	0.9	50.44	8.78	0.31	N	0.97	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15339	15339	T	G	MI.9590	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	593	198	L	R	cTa/cGa	-0.04	0	0	probably_damaging	1	neutral	0.3	neutral	2.91	deleterious	-7.87	deleterious	-4.28	high_impact	4.67	0.94	neutral	0.06	damaging	4.14	23.80	deleterious	0.01	0.35	0.65	disease	0.9	disease	0.7	disease	0.75	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.02	medium_impact	3.05	high_impact	0.13	0.8	47.37	9.09	0.53	N	0.99	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15339	15339	T	A	MI.9591	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	593	198	L	Q	cTa/cAa	-0.04	0	0	probably_damaging	1	neutral	0.26	neutral	2.95	deleterious	-8.09	deleterious	-4.26	high_impact	5.02	0.93	neutral	0.08	damaging	4.02	23.60	deleterious	0.02	0.35	0.67	disease	0.87	disease	0.58	disease	0.68	disease	4	1	deleterious	0.13	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.02	medium_impact	3.36	high_impact	0.29	0.8	47.37	9.09	0.62	P	0.98	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15339	15339	T	C	MI.9592	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	593	198	L	P	cTa/cCa	-0.04	0	0	probably_damaging	1	neutral	0.2	neutral	2.9	deleterious	-8.49	deleterious	-4.96	high_impact	5.02	0.93	neutral	0.06	damaging	3.87	23.50	deleterious	0.01	0.35	0.73	disease	0.87	disease	0.71	disease	0.73	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.1	medium_impact	3.36	high_impact	0.32	0.8	47.37	9.09	0.62	P	0.99	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15341	15341	T	A	MI.9593	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	595	199	F	I	Ttc/Atc	-4.86	0	0.01	probably_damaging	1	neutral	0.46	neutral	3.22	deleterious	-6.35	deleterious	-4.79	high_impact	3.99	0.85	neutral	0.48	neutral	4.18	23.80	deleterious	0.11	0.4	0.3	neutral	0.81	disease	0.63	disease	0.68	disease	4	1	deleterious	0.23	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	0.18	medium_impact	2.43	high_impact	0.35	0.8	57.11	8.71	0.36	N	0.97	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15341	15341	T	C	MI.9594	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	595	199	F	L	Ttc/Ctc	-4.86	0	0.01	probably_damaging	0.99	neutral	0.92	neutral	3.58	deleterious	-5.21	deleterious	-4.75	medium_impact	2.07	0.84	neutral	0.45	neutral	3.60	23.20	deleterious	0.11	0.4	0.28	neutral	0.77	disease	0.43	neutral	0.47	neutral	1	0.99	deleterious	0.47	neutral	1	deleterious	0.72	deleterious	-2.59	low_impact	0.8	medium_impact	0.69	medium_impact	0.52	0.8	57.11	8.71	0.2	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15341	15341	T	G	MI.9595	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	595	199	F	V	Ttc/Gtc	-4.86	0	0.01	probably_damaging	1	neutral	0.5	neutral	3.18	deleterious	-6.39	deleterious	-5.61	high_impact	4.18	0.85	neutral	0.5	neutral	3.95	23.60	deleterious	0.06	0.35	0.32	neutral	0.82	disease	0.65	disease	0.68	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	0.22	medium_impact	2.6	high_impact	0.26	0.8	57.11	8.71	0.35	N	0.99	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15342	15342	T	A	MI.9596	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	596	199	F	Y	tTc/tAc	7.3	1	0	probably_damaging	0.99	neutral	1	neutral	3.11	deleterious	-5	neutral	-2.41	medium_impact	2.93	0.92	neutral	0.47	neutral	4.05	23.70	deleterious	0.17	0.45	0.61	disease	0.78	disease	0.57	disease	0.66	disease	3	0.99	deleterious	0.51	deleterious	1	deleterious	0.78	deleterious	-2.59	low_impact	1.85	high_impact	1.47	medium_impact	0.48	0.8	57.11	8.71	0.47	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15342	15342	T	G	MI.9597	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	596	199	F	C	tTc/tGc	7.3	1	0	probably_damaging	1	neutral	0.21	neutral	3.08	deleterious	-8.87	deleterious	-6.45	high_impact	4.06	0.84	neutral	0.4	neutral	4.06	23.70	deleterious	0.03	0.35	0.72	disease	0.85	disease	0.58	disease	0.69	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	-0.09	medium_impact	2.49	high_impact	0.21	0.8	57.11	8.71	0.51	N	0.99	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15342	15342	T	C	MI.9598	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	596	199	F	S	tTc/tCc	7.3	1	0	probably_damaging	1	neutral	0.47	neutral	3.11	deleterious	-7.39	deleterious	-6.46	medium_impact	3.48	0.84	neutral	0.44	neutral	4.21	23.90	deleterious	0.03	0.35	0.43	neutral	0.85	disease	0.62	disease	0.71	disease	4	1	deleterious	0.24	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.19	medium_impact	1.97	medium_impact	0.22	0.8	57.11	8.71	0.47	N	0.99	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15343	15343	C	A	MI.9599	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	597	199	F	L	ttC/ttA	5.69	1	0	probably_damaging	0.99	neutral	0.92	neutral	3.58	deleterious	-5.21	deleterious	-4.75	medium_impact	2.07	0.84	neutral	0.45	neutral	4.23	23.90	deleterious	0.11	0.4	0.28	neutral	0.77	disease	0.43	neutral	0.47	neutral	1	0.99	deleterious	0.47	neutral	1	deleterious	0.72	deleterious	-2.59	low_impact	0.8	medium_impact	0.69	medium_impact	0.52	0.8	57.11	8.71	0.4	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8569	8569	C	G	MI.96	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	43	15	L	V	Cta/Gta	-2.88	0	0	probably_damaging	0.99	neutral	0.08	neutral	4.52	neutral	-1.34	neutral	-1.78	medium_impact	2.33	0.93	neutral	0.76	neutral	3.11	22.50	deleterious	0.4	0.65	0.52	disease	0.63	disease	0.66	disease	0.63	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.74	deleterious	-2.65	low_impact	-0.31	medium_impact	0.9	medium_impact	0.66	0.9	11.5	26.27	0.4	N	0.33	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8977	8977	A	G	MI.960	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	451	151	I	V	Att/Gtt	-3.34	0	0	probably_damaging	0.93	neutral	0.12	neutral	4.32	neutral	-0.2	neutral	-0.9	medium_impact	2.25	0.79	neutral	0.49	neutral	3.09	22.50	deleterious	0.59	0.7	0.47	neutral	0.52	disease	0.48	neutral	0.44	neutral	1	0.97	neutral	0.1	neutral	1	deleterious	0.67	deleterious	-1.82	low_impact	-0.2	medium_impact	0.83	medium_impact	0.57	0.9	50.44	8.78	0.37	N	0.77	disease_causing	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15343	15343	C	G	MI.9600	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	597	199	F	L	ttC/ttG	5.69	1	0	probably_damaging	0.99	neutral	0.92	neutral	3.58	deleterious	-5.21	deleterious	-4.75	medium_impact	2.07	0.84	neutral	0.45	neutral	3.95	23.60	deleterious	0.11	0.4	0.28	neutral	0.77	disease	0.43	neutral	0.47	neutral	1	0.99	deleterious	0.47	neutral	1	deleterious	0.72	deleterious	-2.59	low_impact	0.8	medium_impact	0.69	medium_impact	0.52	0.8	57.11	8.71	0.4	N	0.92	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15344	15344	T	A	MI.9601	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	598	200	L	M	Ttg/Atg	-2.57	0	0	probably_damaging	1	neutral	0.26	neutral	2.97	deleterious	-6.82	neutral	-1.64	high_impact	5.62	0.94	neutral	0.11	damaging	3.44	23.00	deleterious	0.19	0.45	0.71	disease	0.59	disease	0.63	disease	0.65	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	-0.02	medium_impact	3.91	high_impact	0.49	0.8	58.16	8.76	0.64	P	0.94	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15344	15344	T	G	MI.9602	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	598	200	L	V	Ttg/Gtg	-2.57	0	0	probably_damaging	0.99	neutral	0.58	neutral	3.13	deleterious	-6.32	neutral	-2.44	high_impact	4.58	0.95	neutral	0.11	damaging	2.99	22.20	deleterious	0.17	0.45	0.44	neutral	0.54	disease	0.65	disease	0.65	disease	3	0.99	deleterious	0.3	neutral	2	deleterious	0.73	deleterious	-2.59	low_impact	0.3	medium_impact	2.97	high_impact	0.53	0.8	58.16	8.76	0.35	N	0.88	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15345	15345	T	G	MI.9603	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	599	200	L	W	tTg/tGg	0.41	0.05	0	probably_damaging	1	neutral	0.19	neutral	2.95	deleterious	-10.07	deleterious	-4.93	high_impact	5.62	0.95	neutral	0.09	damaging	3.78	23.40	deleterious	0.04	0.35	0.95	disease	0.71	disease	0.68	disease	0.8	disease	6	1	deleterious	0.1	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.12	medium_impact	3.91	high_impact	0.13	0.8	58.16	8.76	0.61	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15345	15345	T	C	MI.9604	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	599	200	L	S	tTg/tCg	0.41	0.05	0	probably_damaging	1	neutral	0.64	neutral	2.95	deleterious	-8.7	deleterious	-4.92	high_impact	5.07	0.95	neutral	0.1	damaging	3.72	23.30	deleterious	0.04	0.35	0.84	disease	0.75	disease	0.66	disease	0.73	disease	5	1	deleterious	0.32	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.36	medium_impact	3.41	high_impact	0.19	0.8	58.16	8.76	0.63	P	0.97	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15346	15346	G	T	MI.9605	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	600	200	L	F	ttG/ttT	7.3	0.95	0.08	probably_damaging	1	neutral	0.8	neutral	2.99	deleterious	-7.01	deleterious	-3.28	high_impact	4.38	0.96	neutral	0.1	damaging	3.57	23.10	deleterious	0.12	0.4	0.75	disease	0.69	disease	0.65	disease	0.67	disease	3	1	deleterious	0.4	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.55	medium_impact	2.78	high_impact	0.42	0.8	58.16	8.76	0.48	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15346	15346	G	C	MI.9606	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	600	200	L	F	ttG/ttC	7.3	0.95	0.08	probably_damaging	1	neutral	0.8	neutral	2.99	deleterious	-7.01	deleterious	-3.28	high_impact	4.38	0.96	neutral	0.1	damaging	3.42	23.00	deleterious	0.12	0.4	0.75	disease	0.69	disease	0.65	disease	0.67	disease	3	1	deleterious	0.4	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.55	medium_impact	2.78	high_impact	0.42	0.8	58.16	8.76	0.47	N	0.97	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15347	15347	C	A	MI.9607	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	601	201	H	N	Cac/Aac	-15.18	0	0	probably_damaging	0.99	neutral	0.35	neutral	3.06	deleterious	-8.9	deleterious	-5.75	high_impact	5.07	0.86	neutral	0.13	damaging	2.28	18.06	deleterious	0.15	0.45	0.43	neutral	0.78	disease	0.77	disease	0.72	disease	4	0.99	deleterious	0.18	neutral	2	deleterious	0.77	deleterious	-2.59	low_impact	0.08	medium_impact	3.41	high_impact	0.20	0.8	58.68	8.69	0.59	P	0.97	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15347	15347	C	T	MI.9608	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	601	201	H	Y	Cac/Tac	-15.18	0	0	probably_damaging	0.99	neutral	1	neutral	3	deleterious	-8.28	deleterious	-4.93	high_impact	5.07	0.87	neutral	0.13	damaging	2.11	16.93	deleterious	0.08	0.35	0.85	disease	0.82	disease	0.79	disease	0.75	disease	5	0.99	deleterious	0.51	deleterious	2	deleterious	0.84	deleterious	-2.59	low_impact	1.85	high_impact	3.41	high_impact	0.20	0.8	58.68	8.69	0.64	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15347	15347	C	G	MI.9609	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	601	201	H	D	Cac/Gac	-15.18	0	0	probably_damaging	1	neutral	0.24	neutral	3.04	deleterious	-8.53	deleterious	-7.4	high_impact	5.28	0.84	neutral	0.11	damaging	3.60	23.20	deleterious	0.05	0.35	0.69	disease	0.8	disease	0.84	disease	0.75	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.05	medium_impact	3.6	high_impact	0.15	0.8	58.68	8.69	0.57	P	0.98	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8977	8977	A	C	MI.961	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	451	151	I	L	Att/Ctt	-3.34	0	0	probably_damaging	0.93	deleterious	0.01	neutral	4.35	neutral	-0.26	neutral	-1.8	medium_impact	3.02	0.79	neutral	0.46	neutral	3.78	23.40	deleterious	0.35	0.65	0.51	disease	0.73	disease	0.55	disease	0.63	disease	3	1	deleterious	0.04	neutral	5	deleterious	0.70	deleterious	-1.82	low_impact	-0.84	medium_impact	1.49	medium_impact	0.65	0.9	50.44	8.78	0.31	N	0.83	disease_causing	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15348	15348	A	G	MI.9610	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	602	201	H	R	cAc/cGc	5.46	1	0	probably_damaging	0.99	neutral	0.37	neutral	3.07	deleterious	-8.43	deleterious	-6.57	high_impact	4.72	0.87	neutral	0.09	damaging	1.44	13.01	neutral	0.06	0.35	0.35	neutral	0.82	disease	0.8	disease	0.72	disease	4	0.99	deleterious	0.19	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.1	medium_impact	3.09	high_impact	0.31	0.8	58.68	8.69	0.62	P	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15348	15348	A	C	MI.9611	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	602	201	H	P	cAc/cCc	5.46	1	0	probably_damaging	1	neutral	0.23	neutral	3.01	deleterious	-9.53	deleterious	-8.22	high_impact	4.82	0.88	neutral	0.08	damaging	3.02	22.30	deleterious	0.03	0.35	0.81	disease	0.85	disease	0.85	disease	0.77	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.06	medium_impact	3.18	high_impact	0.11	0.8	58.68	8.69	0.62	P	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15348	15348	A	T	MI.9612	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	602	201	H	L	cAc/cTc	5.46	1	0	probably_damaging	0.99	neutral	0.86	neutral	3.09	deleterious	-8.79	deleterious	-9.04	high_impact	5.07	0.88	neutral	0.11	damaging	2.31	18.25	deleterious	0.04	0.35	0.73	disease	0.87	disease	0.76	disease	0.73	disease	5	0.99	deleterious	0.44	neutral	2	deleterious	0.83	deleterious	-2.59	low_impact	0.65	medium_impact	3.41	high_impact	0.12	0.8	58.68	8.69	0.67	P	0.92	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15349	15349	C	A	MI.9613	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	603	201	H	Q	caC/caA	6.84	1	0	probably_damaging	1	neutral	0.32	neutral	3.11	deleterious	-8.97	deleterious	-6.57	high_impact	4.65	0.91	neutral	0.12	damaging	2.32	18.27	deleterious	0.08	0.35	0.57	disease	0.81	disease	0.77	disease	0.74	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.05	medium_impact	3.03	high_impact	0.25	0.8	58.68	8.69	0.6	P	0.94	polymorphism	1	0.18	rs527236201	Likely_pathogenic	Familial_cancer_of_breast	153609	MedGen:C0346153,OMIM:114480,Orphanet:ORPHA227535,SNOMED_CT:254843006	.	.	.	.	.	.	.	.	.	.	P	.	P	damaging
chrM	15349	15349	C	G	MI.9614	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	603	201	H	Q	caC/caG	6.84	1	0	probably_damaging	1	neutral	0.32	neutral	3.11	deleterious	-8.97	deleterious	-6.57	high_impact	4.65	0.91	neutral	0.12	damaging	1.99	16.14	deleterious	0.08	0.35	0.57	disease	0.81	disease	0.77	disease	0.74	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.05	medium_impact	3.03	high_impact	0.25	0.8	58.68	8.69	0.59	P	0.94	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15350	15350	G	C	MI.9615	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	604	202	E	Q	Gaa/Caa	-0.5	0.46	0	probably_damaging	0.99	neutral	0.45	neutral	3.19	deleterious	-4.19	neutral	-2.05	low_impact	1.36	0.92	neutral	0.11	damaging	1.79	14.90	neutral	0.26	0.45	0.24	neutral	0.67	disease	0.21	neutral	0.36	neutral	3	0.99	deleterious	0.23	neutral	-2	neutral	0.72	deleterious	-2.59	low_impact	0.18	medium_impact	0.04	medium_impact	0.26	0.8	56.84	8.3	0.3	N	0.94	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15350	15350	G	A	MI.9616	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	604	202	E	K	Gaa/Aaa	-0.5	0.46	0	probably_damaging	0.99	neutral	0.54	neutral	3.33	deleterious	-3.7	deleterious	-3.07	medium_impact	2.8	0.96	neutral	0.09	damaging	2.94	22.00	deleterious	0.1	0.4	0.22	neutral	0.89	disease	0.5	neutral	0.68	disease	4	0.99	deleterious	0.28	neutral	1	deleterious	0.79	deleterious	-2.59	low_impact	0.26	medium_impact	1.35	medium_impact	0.48	0.8	56.84	8.3	0.23	N	1.00	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15351	15351	A	C	MI.9617	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	605	202	E	A	gAa/gCa	4.08	1	0	probably_damaging	0.99	neutral	0.71	neutral	3.16	deleterious	-3.71	deleterious	-4.69	high_impact	4.18	0.94	neutral	0.15	damaging	3.35	22.90	deleterious	0.09	0.35	0.31	neutral	0.72	disease	0.58	disease	0.63	disease	3	0.99	deleterious	0.36	neutral	2	deleterious	0.75	deleterious	-2.59	low_impact	0.43	medium_impact	2.6	high_impact	0.17	0.8	56.84	8.3	0.42	N	0.83	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15351	15351	A	T	MI.9618	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	605	202	E	V	gAa/gTa	4.08	1	0	probably_damaging	0.99	neutral	0.57	neutral	3.08	neutral	-1.47	deleterious	-5.52	high_impact	3.6	0.93	neutral	0.12	damaging	2.68	20.70	deleterious	0.05	0.35	0.42	neutral	0.86	disease	0.61	disease	0.68	disease	4	0.99	deleterious	0.29	neutral	2	deleterious	0.78	deleterious	-2.59	low_impact	0.29	medium_impact	2.08	high_impact	0.20	0.8	56.84	8.3	0.39	N	0.89	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15351	15351	A	G	MI.9619	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	605	202	E	G	gAa/gGa	4.08	1	0	probably_damaging	1	neutral	0.46	neutral	3.08	deleterious	-4.68	deleterious	-5.49	high_impact	3.76	0.94	neutral	0.14	damaging	4.06	23.70	deleterious	0.07	0.35	0.53	disease	0.75	disease	0.59	disease	0.63	disease	3	0.99	deleterious	0.23	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.18	medium_impact	2.22	high_impact	0.14	0.8	56.84	8.3	0.47	N	0.77	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8978	8978	T	A	MI.962	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	452	151	I	N	aTt/aAt	8.69	1	0	probably_damaging	1	deleterious	0	neutral	4.23	deleterious	-3.84	deleterious	-6.31	high_impact	3.88	0.82	neutral	0.49	neutral	4.46	24.20	deleterious	0.31	0.65	0.84	disease	0.85	disease	0.69	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.23	high_impact	0.70	0.9	50.44	8.78	0.53	P	1.00	disease_causing	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15352	15352	A	T	MI.9620	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	606	202	E	D	gaA/gaT	6.84	1	0	probably_damaging	0.95	neutral	0.38	neutral	3.11	deleterious	-3.75	neutral	-2.31	medium_impact	2.48	0.88	neutral	0.26	damaging	1.93	15.77	deleterious	0.24	0.45	0.42	neutral	0.73	disease	0.41	neutral	0.47	neutral	1	0.96	neutral	0.22	neutral	1	deleterious	0.73	deleterious	-1.92	low_impact	0.11	medium_impact	1.06	medium_impact	0.29	0.8	56.84	8.3	0.54	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15352	15352	A	C	MI.9621	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	606	202	E	D	gaA/gaC	6.84	1	0	probably_damaging	0.95	neutral	0.38	neutral	3.11	deleterious	-3.75	neutral	-2.31	medium_impact	2.48	0.88	neutral	0.26	damaging	1.83	15.19	deleterious	0.24	0.45	0.42	neutral	0.73	disease	0.41	neutral	0.47	neutral	1	0.96	neutral	0.22	neutral	1	deleterious	0.73	deleterious	-1.92	low_impact	0.11	medium_impact	1.06	medium_impact	0.29	0.8	56.84	8.3	0.53	N	0.91	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15353	15353	A	C	MI.9622	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	607	203	T	P	Acg/Ccg	1.33	1	0	possibly_damaging	0.66	neutral	0.26	neutral	3.08	deleterious	-5.74	deleterious	-4.66	high_impact	4.47	0.95	neutral	0.06	damaging	3.24	22.80	deleterious	0.06	0.35	0.43	neutral	0.78	disease	0.59	disease	0.66	disease	3	0.78	neutral	0.3	neutral	1	deleterious	0.67	deleterious	-1	medium_impact	-0.02	medium_impact	2.87	high_impact	0.19	0.8	58.68	8.17	0.47	N	0.96	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15353	15353	A	G	MI.9623	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	607	203	T	A	Acg/Gcg	1.33	1	0	benign	0.01	neutral	0.64	neutral	3.14	deleterious	-3.48	deleterious	-3.79	medium_impact	3.48	0.98	neutral	0.16	damaging	1.64	14.06	neutral	0.23	0.45	0.29	neutral	0.56	disease	0.59	disease	0.62	disease	2	0.35	neutral	0.82	deleterious	-3	neutral	0.17	neutral	1.13	medium_impact	0.36	medium_impact	1.97	medium_impact	0.24	0.8	58.68	8.17	0.41	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15353	15353	A	T	MI.9624	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	607	203	T	S	Acg/Tcg	1.33	1	0	benign	0.12	neutral	0.55	neutral	3.16	neutral	-1.49	deleterious	-2.87	medium_impact	2.04	0.97	neutral	0.31	neutral	1.47	13.14	neutral	0.38	0.5	0.3	neutral	0.5	neutral	0.33	neutral	0.33	neutral	3	0.36	neutral	0.72	deleterious	-3	neutral	0.23	neutral	0.08	medium_impact	0.27	medium_impact	0.66	medium_impact	0.35	0.8	58.68	8.17	0.39	N	0.79	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15354	15354	C	T	MI.9625	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	608	203	T	M	aCg/aTg	2.48	1	0	probably_damaging	0.93	neutral	0.24	neutral	3.05	deleterious	-6.75	deleterious	-4.65	high_impact	3.92	0.94	neutral	0.09	damaging	3.97	23.60	deleterious	0.12	0.4	0.64	disease	0.75	disease	0.54	disease	0.63	disease	3	0.95	neutral	0.16	neutral	2	deleterious	0.72	deleterious	-1.78	low_impact	-0.05	medium_impact	2.37	high_impact	0.27	0.8	58.68	8.17	0.43	N	0.96	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15354	15354	C	A	MI.9626	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	608	203	T	K	aCg/aAg	2.48	1	0	benign	0.26	neutral	0.46	neutral	3.16	deleterious	-5.37	deleterious	-4.57	medium_impact	2.68	0.96	neutral	0.07	damaging	4.15	23.80	deleterious	0.11	0.4	0.23	neutral	0.82	disease	0.44	neutral	0.52	disease	0	0.44	neutral	0.6	deleterious	-3	neutral	0.53	deleterious	-0.31	medium_impact	0.18	medium_impact	1.24	medium_impact	0.28	0.8	58.68	8.17	0.46	N	0.97	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15356	15356	G	C	MI.9627	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	610	204	G	R	Gga/Cga	-2.34	0	0	probably_damaging	1	neutral	0.35	neutral	2.83	deleterious	-11.34	deleterious	-6.58	high_impact	5.08	0.79	neutral	0.03	damaging	3.99	23.60	deleterious	0.02	0.35	0.86	disease	0.87	disease	0.81	disease	0.7	disease	4	1	deleterious	0.18	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	0.08	medium_impact	3.42	high_impact	0.67	0.85	57.89	8.82	0.61	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15356	15356	G	T	MI.9628	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	610	204	G	W	Gga/Tga	-2.34	0	0	probably_damaging	1	neutral	0.18	neutral	2.78	deleterious	-13.3	deleterious	-6.58	high_impact	5.28	0.86	neutral	0.05	damaging	4.46	24.20	deleterious	0.03	0.35	0.98	disease	0.88	disease	0.8	disease	0.79	disease	6	1	deleterious	0.09	neutral	2	deleterious	0.89	deleterious	-3.53	low_impact	-0.14	medium_impact	3.6	high_impact	0.11	0.8	57.89	8.82	0.54	P	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15357	15357	G	A	MI.9629	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	611	204	G	E	gGa/gAa	5.92	1	0	probably_damaging	1	neutral	0.3	neutral	2.84	deleterious	-10.87	deleterious	-6.58	high_impact	5.28	0.72	neutral	0.04	damaging	3.90	23.50	deleterious	0.02	0.35	0.53	disease	0.87	disease	0.81	disease	0.72	disease	4	1	deleterious	0.15	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.02	medium_impact	3.6	high_impact	0.25	0.8	57.89	8.82	0.63	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	COSM1155591	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8978	8978	T	G	MI.963	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	452	151	I	S	aTt/aGt	8.69	1	0	probably_damaging	0.99	neutral	0.18	neutral	4.35	neutral	-0.72	deleterious	-5.37	medium_impact	2.21	0.82	neutral	0.6	neutral	4.32	24.00	deleterious	0.33	0.65	0.44	neutral	0.87	disease	0.64	disease	0.66	disease	3	0.99	deleterious	0.1	neutral	1	deleterious	0.80	deleterious	-2.65	low_impact	-0.08	medium_impact	0.8	medium_impact	0.59	0.9	50.44	8.78	0.47	N	0.98	disease_causing	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15357	15357	G	T	MI.9630	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	611	204	G	V	gGa/gTa	5.92	1	0	probably_damaging	1	neutral	0.52	neutral	2.79	deleterious	-11.21	deleterious	-7.4	high_impact	5.62	0.81	neutral	0.06	damaging	3.88	23.50	deleterious	0.02	0.35	0.9	disease	0.85	disease	0.76	disease	0.7	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.24	medium_impact	3.91	high_impact	0.13	0.8	57.89	8.82	0.65	P	1.00	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15357	15357	G	C	MI.9631	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	611	204	G	A	gGa/gCa	5.92	1	0	probably_damaging	1	neutral	0.51	neutral	2.84	deleterious	-9.59	deleterious	-4.93	high_impact	5.28	0.86	neutral	0.07	damaging	3.15	22.60	deleterious	0.05	0.35	0.76	disease	0.69	disease	0.76	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.23	medium_impact	3.6	high_impact	0.39	0.8	57.89	8.82	0.7	P	0.84	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15359	15359	T	A	MI.9632	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	613	205	S	T	Tca/Aca	-2.8	0	0	probably_damaging	0.96	neutral	0.47	neutral	3.09	deleterious	-7.21	neutral	-2.47	high_impact	4.92	0.94	neutral	0.1	damaging	2.02	16.31	deleterious	0.22	0.45	0.56	disease	0.69	disease	0.6	disease	0.65	disease	3	0.96	neutral	0.26	neutral	2	deleterious	0.74	deleterious	-2.02	low_impact	0.19	medium_impact	3.27	high_impact	0.47	0.8	58.16	8.73	0.62	P	0.70	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15359	15359	T	G	MI.9633	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	613	205	S	A	Tca/Gca	-2.8	0	0	probably_damaging	0.98	neutral	0.5	neutral	3.08	deleterious	-6.37	neutral	-2.47	high_impact	3.87	0.96	neutral	0.14	damaging	1.99	16.13	deleterious	0.25	0.45	0.51	disease	0.54	disease	0.59	disease	0.54	disease	1	0.98	neutral	0.26	neutral	2	deleterious	0.70	deleterious	-2.31	low_impact	0.22	medium_impact	2.32	high_impact	0.36	0.8	58.16	8.73	0.32	N	0.46	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15359	15359	T	C	MI.9634	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	613	205	S	P	Tca/Cca	-2.8	0	0	probably_damaging	1	neutral	0.26	neutral	3.05	deleterious	-8.5	deleterious	-4.11	high_impact	4.72	0.95	neutral	0.04	damaging	3.64	23.20	deleterious	0.04	0.35	0.79	disease	0.78	disease	0.71	disease	0.73	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.02	medium_impact	3.09	high_impact	0.09	0.8	58.16	8.73	0.64	P	1.00	polymorphism	1	0.18	.	.	.	.	.	.	COSM1155594	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15360	15360	C	T	MI.9635	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	614	205	S	L	tCa/tTa	7.3	1	0	probably_damaging	1	neutral	0.76	neutral	3.09	deleterious	-8.69	deleterious	-4.93	high_impact	5.07	0.95	neutral	0.06	damaging	4.44	24.20	deleterious	0.04	0.35	0.34	neutral	0.82	disease	0.7	disease	0.7	disease	4	1	deleterious	0.38	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	0.49	medium_impact	3.41	high_impact	0.40	0.8	58.16	8.73	0.65	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15360	15360	C	G	MI.9636	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	614	205	S	W	tCa/tGa	7.3	1	0	probably_damaging	1	neutral	0.18	neutral	2.99	deleterious	-11.43	deleterious	-5.76	high_impact	5.62	0.96	neutral	0.09	damaging	4.30	24.00	deleterious	0.05	0.35	0.87	disease	0.85	disease	0.76	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.14	medium_impact	3.91	high_impact	0.11	0.8	58.16	8.73	0.63	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15362	15362	A	C	MI.9637	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	616	206	N	H	Aac/Cac	-6.47	0	0	probably_damaging	1	neutral	0.22	neutral	2.98	deleterious	-6.86	deleterious	-3.88	high_impact	4.49	0.93	neutral	0.24	damaging	3.12	22.60	deleterious	0.33	0.5	0.79	disease	0.79	disease	0.72	disease	0.73	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.08	medium_impact	2.88	high_impact	0.12	0.8	40.53	8.41	0.49	N	0.98	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15362	15362	A	T	MI.9638	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	616	206	N	Y	Aac/Tac	-6.47	0	0	probably_damaging	1	neutral	0.19	neutral	3.02	deleterious	-7.49	deleterious	-6.16	high_impact	5.18	0.94	neutral	0.31	neutral	3.79	23.40	deleterious	0.08	0.35	0.86	disease	0.85	disease	0.72	disease	0.75	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	-0.12	medium_impact	3.51	high_impact	0.13	0.8	40.53	8.41	0.63	P	1.00	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15362	15362	A	G	MI.9639	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	616	206	N	D	Aac/Gac	-6.47	0	0	probably_damaging	1	neutral	0.52	neutral	3	deleterious	-4.82	deleterious	-3.81	high_impact	4.83	0.92	neutral	0.33	neutral	3.76	23.40	deleterious	0.54	0.6	0.53	disease	0.73	disease	0.71	disease	0.71	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	0.24	medium_impact	3.19	high_impact	0.24	0.8	40.53	8.41	0.64	P	0.95	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8978	8978	T	C	MI.964	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	452	151	I	T	aTt/aCt	8.69	1	0	probably_damaging	0.99	neutral	0.08	neutral	4.36	neutral	-1.11	deleterious	-4.46	medium_impact	2.84	0.82	neutral	0.5	neutral	3.38	23.00	deleterious	0.51	0.65	0.4	neutral	0.75	disease	0.63	disease	0.66	disease	3	1	deleterious	0.05	neutral	1	deleterious	0.77	deleterious	-2.65	low_impact	-0.31	medium_impact	1.34	medium_impact	0.69	0.9	50.44	8.78	0.49	P	0.99	disease_causing	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15363	15363	A	T	MI.9640	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	617	206	N	I	aAc/aTc	6.61	1	0	probably_damaging	1	neutral	0.18	neutral	3.02	deleterious	-7.07	deleterious	-6.88	high_impact	5.18	0.94	neutral	0.39	neutral	3.84	23.40	deleterious	0.09	0.35	0.82	disease	0.87	disease	0.67	disease	0.72	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.14	medium_impact	3.51	high_impact	0.12	0.8	40.53	8.41	0.69	P	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15363	15363	A	G	MI.9641	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	617	206	N	S	aAc/aGc	6.61	1	0	probably_damaging	0.99	neutral	0.99	neutral	3.1	neutral	-2.48	deleterious	-3.59	low_impact	0.88	0.96	neutral	0.69	neutral	2.66	20.60	deleterious	0.42	0.55	0.29	neutral	0.65	disease	0.42	neutral	0.43	neutral	1	0.99	deleterious	0.5	deleterious	-2	neutral	0.71	deleterious	-2.59	low_impact	1.3	medium_impact	-0.39	medium_impact	0.21	0.8	40.53	8.41	0.44	N	0.86	polymorphism	1	0.11	rs527236182	Likely_pathogenic	Neoplasm_of_ovary	153612	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	3.57	.	.	.	.	.	.	P	.	P	neutral
chrM	15363	15363	A	C	MI.9642	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	617	206	N	T	aAc/aCc	6.61	1	0	probably_damaging	1	neutral	0.43	neutral	3.11	deleterious	-5.19	deleterious	-4.31	medium_impact	2.73	0.97	neutral	0.41	neutral	3.31	22.90	deleterious	0.26	0.45	0.32	neutral	0.74	disease	0.56	disease	0.48	neutral	0	1	deleterious	0.22	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	0.16	medium_impact	1.29	medium_impact	0.25	0.8	40.53	8.41	0.52	N	0.94	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15364	15364	C	A	MI.9643	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	618	206	N	K	aaC/aaA	4.54	1	0	probably_damaging	1	neutral	0.58	neutral	3.03	deleterious	-5.37	deleterious	-4.56	high_impact	4.03	0.94	neutral	0.26	damaging	4.43	24.20	deleterious	0.38	0.5	0.59	disease	0.8	disease	0.65	disease	0.67	disease	3	1	deleterious	0.29	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.3	medium_impact	2.47	high_impact	0.32	0.8	40.53	8.41	0.47	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15364	15364	C	G	MI.9644	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	618	206	N	K	aaC/aaG	4.54	1	0	probably_damaging	1	neutral	0.58	neutral	3.03	deleterious	-5.37	deleterious	-4.56	high_impact	4.03	0.94	neutral	0.26	damaging	3.97	23.60	deleterious	0.38	0.5	0.59	disease	0.8	disease	0.65	disease	0.67	disease	3	1	deleterious	0.29	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.3	medium_impact	2.47	high_impact	0.32	0.8	40.53	8.41	0.47	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15365	15365	A	C	MI.9645	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	619	207	N	H	Aac/Cac	-3.26	0	0	probably_damaging	1	neutral	0.45	neutral	3.02	deleterious	-7.06	deleterious	-4.09	high_impact	5.61	0.93	neutral	0.08	damaging	2.98	22.20	deleterious	0.18	0.45	0.88	disease	0.78	disease	0.81	disease	0.74	disease	5	1	deleterious	0.23	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.18	medium_impact	3.9	high_impact	0.18	0.8	56.84	8.75	0.73	P	0.98	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15365	15365	A	T	MI.9646	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	619	207	N	Y	Aac/Tac	-3.26	0	0	probably_damaging	1	neutral	0.6	neutral	3.01	deleterious	-6.37	deleterious	-6.55	high_impact	5.26	0.94	neutral	0.09	damaging	3.55	23.10	deleterious	0.06	0.35	0.93	disease	0.84	disease	0.8	disease	0.77	disease	5	1	deleterious	0.3	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.32	medium_impact	3.58	high_impact	0.15	0.8	56.84	8.75	0.65	P	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15365	15365	A	G	MI.9647	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	619	207	N	D	Aac/Gac	-3.26	0	0	probably_damaging	1	neutral	0.28	neutral	3.05	deleterious	-6.41	deleterious	-4.09	high_impact	5.06	0.93	neutral	0.1	damaging	3.59	23.20	deleterious	0.33	0.5	0.48	neutral	0.71	disease	0.81	disease	0.69	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	0	medium_impact	3.4	high_impact	0.23	0.8	56.84	8.75	0.68	P	0.95	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15366	15366	A	C	MI.9648	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	620	207	N	T	aAc/aCc	8.44	1	0	probably_damaging	1	neutral	0.38	neutral	3.08	deleterious	-4.91	deleterious	-4.9	high_impact	4.71	0.96	neutral	0.13	damaging	3.83	23.40	deleterious	0.14	0.4	0.8	disease	0.79	disease	0.79	disease	0.74	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.11	medium_impact	3.08	high_impact	0.21	0.8	56.84	8.75	0.75	P	0.94	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15366	15366	A	T	MI.9649	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	620	207	N	I	aAc/aTc	8.44	1	0	probably_damaging	1	neutral	0.38	neutral	3.02	neutral	-2.47	deleterious	-7.37	high_impact	5.61	0.94	neutral	0.11	damaging	4.49	24.30	deleterious	0.07	0.35	0.93	disease	0.86	disease	0.78	disease	0.74	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.11	medium_impact	3.9	high_impact	0.09	0.8	56.84	8.75	0.75	P	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8979	8979	T	A	MI.965	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	453	151	I	M	atT/atA	7.53	1	0	probably_damaging	1	neutral	0.05	neutral	4.25	neutral	-2.09	deleterious	-2.71	medium_impact	2.29	0.85	neutral	0.6	neutral	3.69	23.30	deleterious	0.52	0.65	0.73	disease	0.64	disease	0.45	neutral	0.49	neutral	0	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.43	medium_impact	0.87	medium_impact	0.83	0.9	50.44	8.78	0.53	P	0.75	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15366	15366	A	G	MI.9650	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	620	207	N	S	aAc/aGc	8.44	1	0	probably_damaging	0.99	neutral	0.52	neutral	3.08	deleterious	-5.2	deleterious	-4.09	high_impact	4.02	0.93	neutral	0.09	damaging	3.34	22.90	deleterious	0.29	0.45	0.6	disease	0.74	disease	0.73	disease	0.7	disease	4	0.99	deleterious	0.27	neutral	2	deleterious	0.80	deleterious	-2.59	low_impact	0.24	medium_impact	2.46	high_impact	0.19	0.8	56.84	8.75	0.56	P	0.86	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15367	15367	C	A	MI.9651	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	621	207	N	K	aaC/aaA	6.84	1	0	probably_damaging	1	neutral	0.25	neutral	3.1	deleterious	-5.76	deleterious	-4.91	high_impact	5.26	0.96	neutral	0.12	damaging	4.52	24.30	deleterious	0.18	0.45	0.77	disease	0.78	disease	0.82	disease	0.73	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.04	medium_impact	3.58	high_impact	0.24	0.8	56.84	8.75	0.77	P	1.00	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15367	15367	C	G	MI.9652	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	621	207	N	K	aaC/aaG	6.84	1	0	probably_damaging	1	neutral	0.25	neutral	3.1	deleterious	-5.76	deleterious	-4.91	high_impact	5.26	0.96	neutral	0.12	damaging	4.08	23.70	deleterious	0.18	0.45	0.77	disease	0.78	disease	0.82	disease	0.73	disease	5	1	deleterious	0.13	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.04	medium_impact	3.58	high_impact	0.24	0.8	56.84	8.75	0.77	P	1.00	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15368	15368	C	T	MI.9653	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	622	208	P	S	Ccc/Tcc	0.41	0.99	0	probably_damaging	1	neutral	0.49	neutral	3.12	deleterious	-6.82	deleterious	-6.56	high_impact	4.42	0.84	neutral	0.07	damaging	3.86	23.50	deleterious	0.1	0.4	0.5	disease	0.77	disease	0.67	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.21	medium_impact	2.82	high_impact	0.05	0.8	57.37	8.72	0.43	N	0.85	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15368	15368	C	G	MI.9654	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	622	208	P	A	Ccc/Gcc	0.41	0.99	0	probably_damaging	1	neutral	0.49	neutral	2.99	deleterious	-6.66	deleterious	-6.56	high_impact	5.62	0.87	neutral	0.11	damaging	3.02	22.30	deleterious	0.14	0.4	0.58	disease	0.58	disease	0.76	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.21	medium_impact	3.91	high_impact	0.66	0.8	57.37	8.72	0.6	P	0.82	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15368	15368	C	A	MI.9655	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	622	208	P	T	Ccc/Acc	0.41	0.99	0	probably_damaging	1	neutral	0.44	neutral	2.97	deleterious	-7.25	deleterious	-6.56	high_impact	4.92	0.82	neutral	0.08	damaging	3.86	23.50	deleterious	0.11	0.4	0.66	disease	0.79	disease	0.76	disease	0.71	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.17	medium_impact	3.27	high_impact	0.44	0.8	57.37	8.72	0.61	P	0.96	polymorphism	1	0.44	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15369	15369	C	G	MI.9656	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	623	208	P	R	cCc/cGc	7.07	1	0	probably_damaging	1	neutral	0.34	neutral	2.98	deleterious	-7.61	deleterious	-7.38	high_impact	5.07	0.82	neutral	0.05	damaging	3.70	23.30	deleterious	0.05	0.35	0.73	disease	0.81	disease	0.82	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.07	medium_impact	3.41	high_impact	0.23	0.8	57.37	8.72	0.69	P	0.81	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15369	15369	C	A	MI.9657	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	623	208	P	H	cCc/cAc	7.07	1	0	probably_damaging	1	neutral	0.57	neutral	2.93	deleterious	-7.29	deleterious	-7.38	high_impact	5.62	0.84	neutral	0.07	damaging	4.08	23.70	deleterious	0.06	0.35	0.84	disease	0.81	disease	0.81	disease	0.72	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.29	medium_impact	3.91	high_impact	0.25	0.8	57.37	8.72	0.71	P	0.71	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15369	15369	C	T	MI.9658	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	623	208	P	L	cCc/cTc	7.07	1	0	probably_damaging	1	neutral	0.69	neutral	2.95	deleterious	-6.54	deleterious	-8.2	high_impact	5.07	0.85	neutral	0.05	damaging	4.47	24.20	deleterious	0.08	0.35	0.73	disease	0.79	disease	0.75	disease	0.72	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.41	medium_impact	3.41	high_impact	0.66	0.8	57.37	8.72	0.68	P	1.00	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15371	15371	C	A	MI.9659	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	625	209	L	M	Cta/Ata	-11.05	0	0	probably_damaging	1	neutral	0.18	neutral	3.08	neutral	-1.13	neutral	-0.4	low_impact	1.58	0.88	neutral	0.72	neutral	2.57	19.91	deleterious	0.27	0.45	0.61	disease	0.15	neutral	0.22	neutral	0.39	neutral	2	1	deleterious	0.09	neutral	-2	neutral	0.65	deleterious	-3.53	low_impact	-0.14	medium_impact	0.24	medium_impact	0.54	0.8	23.42	40.51	0.5	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8979	8979	T	G	MI.966	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	453	151	I	M	atT/atG	7.53	1	0	probably_damaging	1	neutral	0.05	neutral	4.25	neutral	-2.09	deleterious	-2.71	medium_impact	2.29	0.85	neutral	0.6	neutral	3.42	23.00	deleterious	0.52	0.65	0.73	disease	0.64	disease	0.45	neutral	0.49	neutral	0	1	deleterious	0.03	neutral	1	deleterious	0.76	deleterious	-3.6	low_impact	-0.43	medium_impact	0.87	medium_impact	0.83	0.9	50.44	8.78	0.52	P	0.75	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15371	15371	C	G	MI.9660	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	625	209	L	V	Cta/Gta	-11.05	0	0	probably_damaging	0.99	neutral	0.45	neutral	3.11	neutral	-0.15	neutral	-0.2	medium_impact	2.31	0.84	neutral	0.68	neutral	1.81	15.02	deleterious	0.3	0.45	0.36	neutral	0.23	neutral	0.25	neutral	0.46	neutral	1	0.99	deleterious	0.23	neutral	1	deleterious	0.62	deleterious	-2.59	low_impact	0.18	medium_impact	0.9	medium_impact	0.35	0.8	23.42	40.51	0.42	N	0.21	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15372	15372	T	G	MI.9661	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	626	209	L	R	cTa/cGa	-1.19	0	0	probably_damaging	1	neutral	0.57	neutral	3.19	neutral	3.11	neutral	-1.9	high_impact	4.55	0.84	neutral	0.52	neutral	4.22	23.90	deleterious	0.06	0.35	0.7	disease	0.65	disease	0.66	disease	0.71	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.29	medium_impact	2.94	high_impact	0.10	0.8	23.42	40.51	0.44	N	0.35	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15372	15372	T	A	MI.9662	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	626	209	L	Q	cTa/cAa	-1.19	0	0	probably_damaging	1	neutral	0.62	neutral	3.11	neutral	2.46	neutral	-1.79	high_impact	4.21	0.84	neutral	0.57	neutral	4.11	23.70	deleterious	0.08	0.35	0.72	disease	0.53	disease	0.6	disease	0.67	disease	3	1	deleterious	0.31	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	0.34	medium_impact	2.63	high_impact	0.17	0.8	23.42	40.51	0.33	N	0.27	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15372	15372	T	C	MI.9663	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	626	209	L	P	cTa/cCa	-1.19	0	0	probably_damaging	1	neutral	0.57	neutral	3.15	neutral	-0.68	neutral	-2.13	high_impact	4.55	0.78	neutral	0.42	neutral	3.90	23.50	deleterious	0.06	0.35	0.79	disease	0.71	disease	0.57	disease	0.72	disease	4	1	deleterious	0.29	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.29	medium_impact	2.94	high_impact	0.19	0.8	23.42	40.51	0.37	N	0.50	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15374	15374	G	C	MI.9664	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	628	210	G	R	Gga/Cga	-1.88	0	0	probably_damaging	1	neutral	0.35	neutral	3.24	deleterious	-8.3	deleterious	-6.54	high_impact	4.8	0.83	neutral	0.04	damaging	3.96	23.60	deleterious	0.03	0.35	0.85	disease	0.77	disease	0.78	disease	0.73	disease	5	1	deleterious	0.18	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.08	medium_impact	3.17	high_impact	0.73	0.85	57.37	8.84	0.66	P	0.99	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15374	15374	G	T	MI.9665	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	628	210	G	W	Gga/Tga	-1.88	0	0	probably_damaging	1	neutral	0.18	neutral	3.04	deleterious	-10.75	deleterious	-6.55	high_impact	5.6	0.84	neutral	0.05	damaging	4.47	24.20	deleterious	0.04	0.35	0.59	disease	0.79	disease	0.77	disease	0.71	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	-0.14	medium_impact	3.89	high_impact	0.06	0.8	57.37	8.84	0.55	N	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15375	15375	G	A	MI.9666	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	629	210	G	E	gGa/gAa	8.9	1	0	probably_damaging	1	neutral	0.27	neutral	3.16	deleterious	-7.63	deleterious	-6.54	high_impact	5.25	0.82	neutral	0.05	damaging	3.97	23.60	deleterious	0.03	0.35	0.85	disease	0.81	disease	0.73	disease	0.69	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	-0.01	medium_impact	3.57	high_impact	0.15	0.8	57.37	8.84	0.7	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	COSM1138313	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15375	15375	G	C	MI.9667	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	629	210	G	A	gGa/gCa	8.9	1	0	probably_damaging	1	neutral	0.51	neutral	3.17	deleterious	-5.83	deleterious	-4.9	high_impact	4.91	0.84	neutral	0.1	damaging	3.15	22.60	deleterious	0.06	0.35	0.77	disease	0.56	disease	0.57	disease	0.63	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.23	medium_impact	3.26	high_impact	0.34	0.8	57.37	8.84	0.68	P	0.84	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15375	15375	G	T	MI.9668	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	629	210	G	V	gGa/gTa	8.9	1	0	probably_damaging	1	neutral	0.51	neutral	3.11	deleterious	-7.72	deleterious	-7.36	high_impact	5.05	0.84	neutral	0.07	damaging	3.82	23.40	deleterious	0.03	0.35	0.79	disease	0.78	disease	0.72	disease	0.7	disease	4	1	deleterious	0.26	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.23	medium_impact	3.39	high_impact	0.07	0.8	57.37	8.84	0.65	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15377	15377	A	T	MI.9669	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	631	211	I	F	Atc/Ttc	-3.03	0	0	probably_damaging	1	neutral	0.7	neutral	3.15	neutral	-1.55	neutral	-2.23	medium_impact	2.54	0.85	neutral	0.49	neutral	3.71	23.30	deleterious	0.15	0.45	0.52	disease	0.65	disease	0.3	neutral	0.46	neutral	1	1	deleterious	0.35	neutral	1	deleterious	0.71	deleterious	-3.53	low_impact	0.42	medium_impact	1.11	medium_impact	0.51	0.8	18.68	25.12	0.19	N	0.76	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8980	8980	C	G	MI.967	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	454	152	Q	E	Caa/Gaa	-0.8	0.05	0	probably_damaging	0.94	deleterious	0	neutral	3.9	neutral	-0.72	neutral	-1.91	medium_impact	2.25	0.8	neutral	0.44	neutral	3.19	22.70	deleterious	0.39	0.65	0.62	disease	0.86	disease	0.62	disease	0.8	disease	6	1	deleterious	0.03	neutral	5	deleterious	0.83	deleterious	-1.89	low_impact	-1.4	low_impact	0.83	medium_impact	0.77	0.9	46.9	8.18	0.27	N	0.94	polymorphism	0.68	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15377	15377	A	C	MI.9670	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	631	211	I	L	Atc/Ctc	-3.03	0	0	probably_damaging	0.99	neutral	0.68	neutral	3.23	neutral	3.84	neutral	0.39	neutral_impact	-0.92	0.94	neutral	0.91	neutral	-0.58	0.14	neutral	0.26	0.45	0.23	neutral	0.1	neutral	0.15	neutral	0.28	neutral	4	0.99	deleterious	0.35	neutral	-2	neutral	0.44	deleterious	-2.59	low_impact	0.4	medium_impact	-2.03	low_impact	0.50	0.8	18.68	25.12	0.38	N	0.05	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15377	15377	A	G	MI.9671	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	631	211	I	V	Atc/Gtc	-3.03	0	0	probably_damaging	0.96	neutral	0.51	neutral	3.21	neutral	-2.25	neutral	-0.76	low_impact	1.24	0.88	neutral	0.84	neutral	1.23	11.91	neutral	0.49	0.55	0.18	neutral	0.25	neutral	0.24	neutral	0.44	neutral	1	0.96	neutral	0.28	neutral	-2	neutral	0.55	deleterious	-2.02	low_impact	0.23	medium_impact	-0.07	medium_impact	0.49	0.8	18.68	25.12	0.35	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15378	15378	T	A	MI.9672	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	632	211	I	N	aTc/aAc	-0.96	0	0	probably_damaging	1	neutral	0.33	neutral	3.19	deleterious	-6.74	deleterious	-4.64	medium_impact	2.88	0.83	neutral	0.47	neutral	4.65	24.50	deleterious	0.15	0.4	0.45	neutral	0.76	disease	0.6	disease	0.71	disease	4	1	deleterious	0.17	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	0.06	medium_impact	1.42	medium_impact	0.15	0.8	18.68	25.12	0.32	N	1.00	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15378	15378	T	C	MI.9673	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	632	211	I	T	aTc/aCc	-0.96	0	0	probably_damaging	1	neutral	0.39	neutral	3.34	deleterious	-4.55	deleterious	-2.97	medium_impact	2.15	0.82	neutral	0.66	neutral	3.50	23.10	deleterious	0.11	0.4	0.45	neutral	0.56	disease	0.34	neutral	0.47	neutral	1	1	deleterious	0.2	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	0.12	medium_impact	0.76	medium_impact	0.26	0.8	18.68	25.12	0.32	N	0.96	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15378	15378	T	G	MI.9674	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	632	211	I	S	aTc/aGc	-0.96	0	0	probably_damaging	1	neutral	0.42	neutral	3.25	deleterious	-5.69	deleterious	-3.81	medium_impact	2.5	0.84	neutral	0.46	neutral	4.33	24.00	deleterious	0.04	0.35	0.51	disease	0.74	disease	0.62	disease	0.7	disease	4	1	deleterious	0.21	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	0.15	medium_impact	1.08	medium_impact	0.15	0.8	18.68	25.12	0.27	N	0.94	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15379	15379	C	A	MI.9675	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	633	211	I	M	atC/atA	7.3	0.95	0	probably_damaging	1	neutral	0.22	neutral	3.17	neutral	-2.48	neutral	-0.86	low_impact	1.52	0.89	neutral	0.87	neutral	2.57	19.90	deleterious	0.28	0.45	0.52	disease	0.37	neutral	0.24	neutral	0.4	neutral	2	1	deleterious	0.11	neutral	-2	neutral	0.67	deleterious	-3.53	low_impact	-0.08	medium_impact	0.19	medium_impact	0.52	0.8	18.68	25.12	0.58	P	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15379	15379	C	G	MI.9676	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	633	211	I	M	atC/atG	7.3	0.95	0	probably_damaging	1	neutral	0.22	neutral	3.17	neutral	-2.48	neutral	-0.86	low_impact	1.52	0.89	neutral	0.87	neutral	2.15	17.15	deleterious	0.28	0.45	0.52	disease	0.37	neutral	0.24	neutral	0.4	neutral	2	1	deleterious	0.11	neutral	-2	neutral	0.67	deleterious	-3.53	low_impact	-0.08	medium_impact	0.19	medium_impact	0.52	0.8	18.68	25.12	0.58	P	0.57	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15380	15380	A	T	MI.9677	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	634	212	T	S	Acc/Tcc	-9.22	0	0.01	benign	0.01	neutral	0.42	neutral	3.19	neutral	-1.06	neutral	0.6	neutral_impact	-0.59	0.96	neutral	0.97	neutral	1.57	13.70	neutral	0.57	0.65	0.2	neutral	0.14	neutral	0.18	neutral	0.3	neutral	4	0.57	neutral	0.71	deleterious	-6	neutral	0.09	neutral	1.13	medium_impact	0.15	medium_impact	-1.73	low_impact	0.60	0.8	17.11	27.27	0.54	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15380	15380	A	C	MI.9678	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	634	212	T	P	Acc/Ccc	-9.22	0	0.01	benign	0.01	neutral	0.22	neutral	3.14	neutral	-2.8	neutral	-0.87	neutral_impact	-0.82	0.97	neutral	0.97	neutral	1.71	14.45	neutral	0.16	0.45	0.51	disease	0.36	neutral	0.2	neutral	0.36	neutral	3	0.78	neutral	0.61	deleterious	-6	neutral	0.17	neutral	1.13	medium_impact	-0.08	medium_impact	-1.94	low_impact	0.36	0.8	17.11	27.27	0.45	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15380	15380	A	G	MI.9679	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	634	212	T	A	Acc/Gcc	-9.22	0	0.01	benign	0.05	neutral	0.5	neutral	3.19	neutral	-1.08	neutral	-1.21	neutral_impact	0.34	0.81	neutral	0.8	neutral	2.06	16.57	deleterious	0.4	0.5	0.3	neutral	0.16	neutral	0.36	neutral	0.3	neutral	4	0.45	neutral	0.73	deleterious	-6	neutral	0.10	neutral	0.46	medium_impact	0.22	medium_impact	-0.89	medium_impact	0.33	0.8	17.11	27.27	0.36	N	0.16	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8980	8980	C	A	MI.968	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	454	152	Q	K	Caa/Aaa	-0.8	0.05	0	probably_damaging	0.97	deleterious	0	neutral	4.11	neutral	2.59	neutral	-1.71	neutral_impact	0.6	0.79	neutral	0.39	neutral	4.02	23.60	deleterious	0.41	0.65	0.37	neutral	0.86	disease	0.65	disease	0.8	disease	6	1	deleterious	0.02	neutral	2	deleterious	0.75	deleterious	-2.19	low_impact	-1.4	low_impact	-0.58	medium_impact	0.72	0.9	46.9	8.18	0.28	N	0.99	polymorphism	0.51	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15381	15381	C	A	MI.9680	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	635	212	T	N	aCc/aAc	-1.42	0	0	benign	0.18	neutral	0.33	neutral	3.3	neutral	1.26	neutral	2.21	neutral_impact	-2.65	0.89	neutral	0.91	neutral	0.87	9.88	deleterious	0.49	0.55	0.21	neutral	0.06	neutral	0.14	neutral	0.24	neutral	5	0.61	neutral	0.58	deleterious	-6	neutral	0.10	neutral	-0.12	medium_impact	0.06	medium_impact	-3.6	low_impact	0.42	0.8	17.11	27.27	0.5	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15381	15381	C	T	MI.9681	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	635	212	T	I	aCc/aTc	-1.42	0	0	benign	0.41	neutral	0.4	neutral	3.13	neutral	-2.8	neutral	-2.27	neutral_impact	0.35	0.87	neutral	0.84	neutral	2.76	21.10	deleterious	0.27	0.45	0.57	disease	0.32	neutral	0.26	neutral	0.59	disease	2	0.54	neutral	0.5	deleterious	-6	neutral	0.24	neutral	-0.58	medium_impact	0.13	medium_impact	-0.88	medium_impact	0.37	0.8	17.11	27.27	0.31	N	0.57	polymorphism	1	0.03	rs199721378	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15381	15381	C	G	MI.9682	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	635	212	T	S	aCc/aGc	-1.42	0	0	benign	0.01	neutral	0.42	neutral	3.19	neutral	-1.06	neutral	0.6	neutral_impact	-0.59	0.96	neutral	0.97	neutral	1.80	14.97	neutral	0.57	0.65	0.2	neutral	0.14	neutral	0.18	neutral	0.3	neutral	4	0.57	neutral	0.71	deleterious	-6	neutral	0.09	neutral	1.13	medium_impact	0.15	medium_impact	-1.73	low_impact	0.60	0.8	17.11	27.27	0.48	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15383	15383	T	A	MI.9683	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	637	213	S	T	Tcc/Acc	-3.71	0	0	probably_damaging	0.99	neutral	0.4	neutral	3.03	deleterious	-3.08	neutral	-2.18	high_impact	3.72	0.94	neutral	0.43	neutral	2.24	17.77	deleterious	0.59	0.65	0.46	neutral	0.62	disease	0.52	disease	0.44	neutral	1	0.99	deleterious	0.21	neutral	2	deleterious	0.70	deleterious	-2.59	low_impact	0.13	medium_impact	2.18	high_impact	0.59	0.8	18.95	18.09	0.36	N	0.64	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15383	15383	T	C	MI.9684	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	637	213	S	P	Tcc/Ccc	-3.71	0	0	probably_damaging	1	neutral	0.23	neutral	2.99	neutral	-1.56	deleterious	-3.65	medium_impact	3.14	0.96	neutral	0.51	neutral	2.85	21.60	deleterious	0.1	0.4	0.56	disease	0.64	disease	0.38	neutral	0.35	neutral	3	1	deleterious	0.12	neutral	1	deleterious	0.77	deleterious	-3.53	low_impact	-0.06	medium_impact	1.66	medium_impact	0.15	0.8	18.95	18.09	0.41	N	0.40	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15383	15383	T	G	MI.9685	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	637	213	S	A	Tcc/Gcc	-3.71	0	0	probably_damaging	0.99	neutral	0.5	neutral	3.04	neutral	-2.7	neutral	-2.12	high_impact	3.53	0.97	neutral	0.58	neutral	3.39	23.00	deleterious	0.52	0.6	0.32	neutral	0.45	neutral	0.55	disease	0.43	neutral	1	0.99	deleterious	0.26	neutral	2	deleterious	0.68	deleterious	-2.59	low_impact	0.22	medium_impact	2.01	high_impact	0.29	0.8	18.95	18.09	0.35	N	0.41	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15384	15384	C	G	MI.9686	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	638	213	S	C	tCc/tGc	1.79	0.95	0	probably_damaging	1	neutral	0.18	neutral	2.96	deleterious	-6.18	deleterious	-3.78	high_impact	4.87	0.95	neutral	0.34	neutral	3.69	23.30	deleterious	0.12	0.4	0.85	disease	0.72	disease	0.66	disease	0.69	disease	4	1	deleterious	0.09	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	-0.14	medium_impact	3.23	high_impact	0.15	0.8	18.95	18.09	0.7	P	0.52	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15384	15384	C	A	MI.9687	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	638	213	S	Y	tCc/tAc	1.79	0.95	0	probably_damaging	1	neutral	1	neutral	2.97	deleterious	-4.92	deleterious	-4.59	high_impact	4.62	0.95	neutral	0.38	neutral	4.11	23.80	deleterious	0.1	0.4	0.52	disease	0.8	disease	0.7	disease	0.7	disease	4	1	deleterious	0.5	deleterious	2	deleterious	0.76	deleterious	-3.53	low_impact	1.85	high_impact	3	high_impact	0.14	0.8	18.95	18.09	0.49	N	0.99	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15384	15384	C	T	MI.9688	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	638	213	S	F	tCc/tTc	1.79	0.95	0	probably_damaging	1	neutral	0.71	neutral	2.97	deleterious	-5.29	deleterious	-4.59	high_impact	4.32	0.94	neutral	0.45	neutral	4.32	24.00	deleterious	0.12	0.4	0.75	disease	0.8	disease	0.7	disease	0.71	disease	4	1	deleterious	0.36	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.43	medium_impact	2.73	high_impact	0.06	0.8	18.95	18.09	0.45	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15386	15386	C	A	MI.9689	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	640	214	H	N	Cat/Aat	-6.93	0	0	benign	0.18	neutral	0.32	neutral	3.42	neutral	4.68	neutral	2.21	neutral_impact	-3.75	0.93	neutral	0.91	neutral	0.32	5.88	deleterious	0.54	0.6	0.18	neutral	0.1	neutral	0.21	neutral	0.26	neutral	5	0.62	neutral	0.57	deleterious	-6	neutral	0.16	neutral	-0.12	medium_impact	0.05	medium_impact	-4.6	low_impact	0.37	0.8	19.21	19.72	0.36	N	0.04	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8981	8981	A	G	MI.969	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	455	152	Q	R	cAa/cGa	5.68	1	0	probably_damaging	0.97	neutral	1	neutral	4.5	neutral	4.39	neutral	-0.64	neutral_impact	-2.29	0.85	neutral	0.67	neutral	0.80	9.45	deleterious	0.44	0.65	0.53	disease	0.22	neutral	0.46	neutral	0.26	neutral	5	0.97	neutral	0.52	deleterious	-2	neutral	0.69	deleterious	-2.19	low_impact	1.98	high_impact	-3.06	low_impact	0.69	0.9	46.9	8.18	0.44	N	0.91	disease_causing	0.99	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15386	15386	C	T	MI.9690	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	640	214	H	Y	Cat/Tat	-6.93	0	0	benign	0.37	neutral	1	neutral	3.17	neutral	-0.69	neutral	-2.05	neutral_impact	-0.06	0.94	neutral	0.67	neutral	2.28	18.06	deleterious	0.37	0.5	0.57	disease	0.41	neutral	0.53	disease	0.63	disease	3	0.37	neutral	0.82	deleterious	-6	neutral	0.37	neutral	-0.52	medium_impact	1.85	high_impact	-1.25	low_impact	0.38	0.8	19.21	19.72	0.23	N	0.61	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15386	15386	C	G	MI.9691	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	640	214	H	D	Cat/Gat	-6.93	0	0	benign	0.18	neutral	0.24	neutral	3.23	neutral	1.06	neutral	2.31	neutral_impact	-2.92	0.96	neutral	0.95	neutral	0.91	10.14	neutral	0.19	0.45	0.18	neutral	0.1	neutral	0.31	neutral	0.32	neutral	4	0.72	neutral	0.53	deleterious	-6	neutral	0.14	neutral	-0.12	medium_impact	-0.05	medium_impact	-3.84	low_impact	0.38	0.8	19.21	19.72	0.38	N	0.00	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15387	15387	A	T	MI.9692	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	641	214	H	L	cAt/cTt	-0.27	0	0	benign	0.18	neutral	0.65	neutral	3.19	neutral	0.53	deleterious	-2.98	low_impact	0.98	0.95	neutral	0.6	neutral	3.79	23.40	deleterious	0.13	0.4	0.36	neutral	0.49	neutral	0.52	disease	0.51	disease	0	0.23	neutral	0.74	deleterious	-6	neutral	0.26	neutral	-0.12	medium_impact	0.37	medium_impact	-0.3	medium_impact	0.16	0.8	19.21	19.72	0.25	N	0.75	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15387	15387	A	C	MI.9693	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	641	214	H	P	cAt/cCt	-0.27	0	0	benign	0.37	neutral	0.23	neutral	3.26	neutral	-0.26	neutral	-1.41	neutral_impact	0.08	0.94	neutral	0.45	neutral	3.01	22.30	deleterious	0.08	0.35	0.48	neutral	0.73	disease	0.53	disease	0.6	disease	2	0.73	neutral	0.43	neutral	-6	neutral	0.47	deleterious	-0.52	medium_impact	-0.06	medium_impact	-1.12	low_impact	0.25	0.8	19.21	19.72	0.31	N	0.76	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15387	15387	A	G	MI.9694	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	641	214	H	R	cAt/cGt	-0.27	0	0	benign	0.18	neutral	0.34	neutral	3.21	neutral	1.27	neutral	-1.02	neutral_impact	0.12	0.94	neutral	0.55	neutral	2.75	21.10	deleterious	0.29	0.45	0.28	neutral	0.5	disease	0.5	neutral	0.5	disease	0	0.59	neutral	0.58	deleterious	-6	neutral	0.20	neutral	-0.12	medium_impact	0.07	medium_impact	-1.08	low_impact	0.29	0.8	19.21	19.72	0.33	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15388	15388	T	A	MI.9695	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	642	214	H	Q	caT/caA	6.61	0.81	0.01	benign	0.01	neutral	0.29	neutral	3.26	neutral	1.29	neutral	-0.15	neutral_impact	0	0.96	neutral	0.82	neutral	3.36	22.90	deleterious	0.41	0.5	0.21	neutral	0.32	neutral	0.4	neutral	0.43	neutral	1	0.7	neutral	0.64	deleterious	-6	neutral	0.12	neutral	1.13	medium_impact	0.01	medium_impact	-1.19	low_impact	0.35	0.8	19.21	19.72	0.47	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15388	15388	T	G	MI.9696	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	642	214	H	Q	caT/caG	6.61	0.81	0.01	benign	0.01	neutral	0.29	neutral	3.26	neutral	1.29	neutral	-0.15	neutral_impact	0	0.96	neutral	0.82	neutral	3.30	22.90	deleterious	0.41	0.5	0.21	neutral	0.32	neutral	0.4	neutral	0.43	neutral	1	0.7	neutral	0.64	deleterious	-6	neutral	0.12	neutral	1.13	medium_impact	0.01	medium_impact	-1.19	low_impact	0.35	0.8	19.21	19.72	0.46	N	0.41	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15389	15389	T	A	MI.9697	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	643	215	S	T	Tcc/Acc	-1.42	0	0	benign	0.13	neutral	0.4	neutral	3.13	deleterious	-4.06	neutral	-0.38	neutral_impact	0.13	0.93	neutral	0.86	neutral	0.72	8.94	deleterious	0.33	0.5	0.35	neutral	0.18	neutral	0.21	neutral	0.33	neutral	3	0.53	neutral	0.64	deleterious	-6	neutral	0.11	neutral	0.04	medium_impact	0.13	medium_impact	-1.08	low_impact	0.50	0.8	14.21	20.41	0.45	N	0.29	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15389	15389	T	C	MI.9698	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	643	215	S	P	Tcc/Ccc	-1.42	0	0	benign	0	neutral	0.23	neutral	3.07	deleterious	-5.88	neutral	-1.32	low_impact	0.82	0.97	neutral	0.92	neutral	2.44	19.05	deleterious	0.13	0.4	0.61	disease	0.58	disease	0.25	neutral	0.38	neutral	2	0.77	neutral	0.62	deleterious	-6	neutral	0.21	neutral	2.07	high_impact	-0.06	medium_impact	-0.45	medium_impact	0.16	0.8	14.21	20.41	0.39	N	0.92	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15389	15389	T	G	MI.9699	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	643	215	S	A	Tcc/Gcc	-1.42	0	0	benign	0.08	neutral	0.53	neutral	3.17	deleterious	-3.72	neutral	0.28	neutral_impact	0.31	0.91	neutral	0.93	neutral	-0.17	1.28	neutral	0.33	0.5	0.29	neutral	0.06	neutral	0.37	neutral	0.24	neutral	5	0.4	neutral	0.73	deleterious	-6	neutral	0.10	neutral	0.26	medium_impact	0.25	medium_impact	-0.91	medium_impact	0.20	0.8	14.21	20.41	0.41	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8570	8570	T	C	MI.97	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	44	15	L	P	cTa/cCa	-1.49	0	0	probably_damaging	1	deleterious	0.03	neutral	4.38	deleterious	-4.44	deleterious	-5.11	medium_impact	3.48	0.82	neutral	0.18	damaging	3.67	23.20	deleterious	0.2	0.65	0.86	disease	0.88	disease	0.77	disease	0.86	disease	7	1	deleterious	0.02	neutral	5	deleterious	0.87	deleterious	-3.6	low_impact	-0.56	medium_impact	1.89	medium_impact	0.62	0.9	11.5	26.27	0.34	N	0.98	disease_causing	0.99	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8981	8981	A	T	MI.970	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	455	152	Q	L	cAa/cTa	5.68	1	0	probably_damaging	0.97	deleterious	0	neutral	3.87	neutral	-1.65	deleterious	-4.7	medium_impact	2.25	0.79	neutral	0.4	neutral	3.89	23.50	deleterious	0.24	0.65	0.76	disease	0.86	disease	0.59	disease	0.78	disease	6	1	deleterious	0.02	neutral	5	deleterious	0.85	deleterious	-2.19	low_impact	-1.4	low_impact	0.83	medium_impact	0.48	0.9	46.9	8.18	0.47	N	0.99	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15390	15390	C	A	MI.9700	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	644	215	S	Y	tCc/tAc	-4.86	0	0	probably_damaging	0.93	neutral	1	neutral	3.11	deleterious	-4.72	neutral	-2.3	low_impact	0.84	0.9	neutral	0.62	neutral	2.88	21.70	deleterious	0.13	0.4	0.3	neutral	0.56	disease	0.26	neutral	0.44	neutral	1	0.93	neutral	0.54	deleterious	-2	neutral	0.63	deleterious	-1.78	low_impact	1.85	high_impact	-0.43	medium_impact	0.24	0.8	14.21	20.41	0.2	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15390	15390	C	T	MI.9701	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	644	215	S	F	tCc/tTc	-4.86	0	0	probably_damaging	0.99	neutral	0.71	neutral	3.08	neutral	-2	neutral	-2.31	medium_impact	2.19	0.85	neutral	0.53	neutral	3.18	22.70	deleterious	0.12	0.4	0.49	neutral	0.58	disease	0.3	neutral	0.44	neutral	1	0.99	deleterious	0.36	neutral	1	deleterious	0.70	deleterious	-2.59	low_impact	0.43	medium_impact	0.8	medium_impact	0.10	0.8	14.21	20.41	0.19	N	0.91	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15390	15390	C	G	MI.9702	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	644	215	S	C	tCc/tGc	-4.86	0	0	probably_damaging	0.98	neutral	0.18	neutral	3.06	deleterious	-5.76	neutral	-0.57	low_impact	1.81	0.91	neutral	0.64	neutral	2.45	19.13	deleterious	0.15	0.4	0.68	disease	0.44	neutral	0.27	neutral	0.61	disease	2	0.99	deleterious	0.1	neutral	-2	neutral	0.68	deleterious	-2.31	low_impact	-0.14	medium_impact	0.45	medium_impact	0.17	0.8	14.21	20.41	0.47	N	0.46	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15392	15392	G	C	MI.9703	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	646	216	D	H	Gat/Cat	-2.8	0	0	probably_damaging	1	neutral	0.54	neutral	2.93	deleterious	-5.86	deleterious	-5.61	high_impact	4.55	0.91	neutral	0.1	damaging	3.79	23.40	deleterious	0.08	0.35	0.7	disease	0.83	disease	0.72	disease	0.71	disease	4	1	deleterious	0.27	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.26	medium_impact	2.94	high_impact	0.31	0.8	58.42	8.61	0.38	N	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15392	15392	G	A	MI.9704	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	646	216	D	N	Gat/Aat	-2.8	0	0	probably_damaging	1	neutral	0.33	neutral	2.98	deleterious	-4.43	deleterious	-4.01	medium_impact	3.11	0.87	neutral	0.18	damaging	4.18	23.80	deleterious	0.56	0.6	0.54	disease	0.8	disease	0.57	disease	0.64	disease	3	1	deleterious	0.17	neutral	1	deleterious	0.81	deleterious	-3.53	low_impact	0.06	medium_impact	1.63	medium_impact	0.64	0.8	58.42	8.61	0.33	N	0.99	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15392	15392	G	T	MI.9705	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	646	216	D	Y	Gat/Tat	-2.8	0	0	probably_damaging	1	neutral	1	neutral	2.94	deleterious	-6.39	deleterious	-7.23	medium_impact	2.73	0.92	neutral	0.11	damaging	4.03	23.60	deleterious	0.03	0.35	0.79	disease	0.92	disease	0.66	disease	0.7	disease	4	1	deleterious	0.5	deleterious	1	deleterious	0.88	deleterious	-3.53	low_impact	1.85	high_impact	1.29	medium_impact	0.06	0.8	58.42	8.61	0.22	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15393	15393	A	C	MI.9706	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	647	216	D	A	gAt/gCt	9.13	1	0	probably_damaging	1	neutral	0.5	neutral	3	deleterious	-3.21	deleterious	-6.42	high_impact	4.55	0.93	neutral	0.15	damaging	3.71	23.30	deleterious	0.07	0.35	0.43	neutral	0.77	disease	0.67	disease	0.67	disease	3	1	deleterious	0.25	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.22	medium_impact	2.94	high_impact	0.16	0.8	58.42	8.61	0.54	P	0.95	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15393	15393	A	T	MI.9707	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	647	216	D	V	gAt/gTt	9.13	1	0	probably_damaging	1	neutral	0.5	neutral	3.15	neutral	-0.25	deleterious	-7.24	high_impact	4.55	0.92	neutral	0.12	damaging	3.94	23.60	deleterious	0.03	0.35	0.5	neutral	0.9	disease	0.68	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.22	medium_impact	2.94	high_impact	0.02	0.8	58.42	8.61	0.55	P	1.00	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15393	15393	A	G	MI.9708	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	647	216	D	G	gAt/gGt	9.13	1	0	probably_damaging	1	neutral	0.33	neutral	2.94	neutral	-1.98	deleterious	-5.63	high_impact	3.98	0.93	neutral	0.17	damaging	4.10	23.70	deleterious	0.07	0.35	0.65	disease	0.84	disease	0.67	disease	0.71	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.06	medium_impact	2.42	high_impact	0.11	0.8	58.42	8.61	0.57	P	1.00	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15394	15394	T	G	MI.9709	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	648	216	D	E	gaT/gaG	6.84	1	0	probably_damaging	0.99	neutral	0.28	neutral	3.03	deleterious	-3.73	deleterious	-3.17	medium_impact	2.67	0.91	neutral	0.12	damaging	3.61	23.20	deleterious	0.3	0.45	0.4	neutral	0.74	disease	0.53	disease	0.39	neutral	2	1	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-2.59	low_impact	0	medium_impact	1.23	medium_impact	0.53	0.8	58.42	8.61	0.53	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8981	8981	A	C	MI.971	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	455	152	Q	P	cAa/cCa	5.68	1	0	probably_damaging	0.98	deleterious	0	neutral	3.89	neutral	-2.53	deleterious	-4.25	low_impact	1.9	0.67	neutral	0.41	neutral	3.43	23.00	deleterious	0.16	0.65	0.83	disease	0.94	disease	0.61	disease	0.83	disease	7	1	deleterious	0.01	neutral	2	deleterious	0.91	deleterious	-2.36	low_impact	-1.4	low_impact	0.53	medium_impact	0.56	0.9	46.9	8.18	0.4	N	0.98	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15394	15394	T	A	MI.9710	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	648	216	D	E	gaT/gaA	6.84	1	0	probably_damaging	0.99	neutral	0.28	neutral	3.03	deleterious	-3.73	deleterious	-3.17	medium_impact	2.67	0.91	neutral	0.12	damaging	3.72	23.30	deleterious	0.3	0.45	0.4	neutral	0.74	disease	0.53	disease	0.39	neutral	2	1	deleterious	0.15	neutral	1	deleterious	0.78	deleterious	-2.59	low_impact	0	medium_impact	1.23	medium_impact	0.53	0.8	58.42	8.61	0.54	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15395	15395	A	G	MI.9711	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	649	217	K	E	Aaa/Gaa	-0.73	0.16	0	probably_damaging	1	neutral	0.37	neutral	3.04	deleterious	-3.26	deleterious	-3.22	high_impact	5.15	0.92	neutral	0.17	damaging	3.58	23.20	deleterious	0.14	0.4	0.69	disease	0.86	disease	0.74	disease	0.71	disease	4	1	deleterious	0.19	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.1	medium_impact	3.48	high_impact	0.35	0.8	28.42	14.16	0.69	P	0.95	polymorphism	1	0.27	.	.	.	.	.	.	COSM3307732	.	.	A15395G	Possible LHON factor	+	-	Reported	1	.	P	P	damaging
chrM	15395	15395	A	C	MI.9712	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	649	217	K	Q	Aaa/Caa	-0.73	0.16	0	probably_damaging	1	neutral	0.34	neutral	3	deleterious	-3.73	deleterious	-3.2	high_impact	4.69	0.91	neutral	0.18	damaging	2.92	21.90	deleterious	0.23	0.45	0.53	disease	0.8	disease	0.62	disease	0.66	disease	3	1	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.07	medium_impact	3.07	high_impact	0.24	0.8	28.42	14.16	0.58	N	0.93	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15396	15396	A	C	MI.9713	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	650	217	K	T	aAa/aCa	6.84	1	0	probably_damaging	1	neutral	0.48	neutral	3	neutral	-1.1	deleterious	-4.82	high_impact	4.11	0.95	neutral	0.27	damaging	3.65	23.20	deleterious	0.07	0.35	0.77	disease	0.84	disease	0.72	disease	0.71	disease	4	1	deleterious	0.24	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.2	medium_impact	2.54	high_impact	0.09	0.8	28.42	14.16	0.61	P	0.88	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15396	15396	A	T	MI.9714	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	650	217	K	M	aAa/aTa	6.84	1	0	probably_damaging	1	neutral	0.23	neutral	2.96	neutral	-2.86	deleterious	-4.76	medium_impact	3.24	0.96	neutral	0.78	neutral	2.85	21.60	deleterious	0.07	0.35	0.9	disease	0.76	disease	0.44	neutral	0.54	disease	1	1	deleterious	0.12	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	-0.06	medium_impact	1.75	medium_impact	0.17	0.8	28.42	14.16	0.59	P	0.67	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15397	15397	A	C	MI.9715	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	651	217	K	N	aaA/aaC	3.85	1	0	probably_damaging	1	neutral	0.41	neutral	2.99	deleterious	-4.02	deleterious	-4.03	high_impact	4.17	0.91	neutral	0.2	damaging	3.83	23.40	deleterious	0.3	0.45	0.76	disease	0.81	disease	0.73	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.14	medium_impact	2.59	high_impact	0.23	0.8	28.42	14.16	0.56	N	0.84	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15397	15397	A	T	MI.9716	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	651	217	K	N	aaA/aaT	3.85	1	0	probably_damaging	1	neutral	0.41	neutral	2.99	deleterious	-4.02	deleterious	-4.03	high_impact	4.17	0.91	neutral	0.2	damaging	3.90	23.50	deleterious	0.3	0.45	0.76	disease	0.81	disease	0.73	disease	0.71	disease	4	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.14	medium_impact	2.59	high_impact	0.23	0.8	28.42	14.16	0.59	P	0.84	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15398	15398	A	C	MI.9717	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	652	218	I	L	Atc/Ctc	4.77	1	0	benign	0.26	neutral	0.64	neutral	3.06	deleterious	-3.65	neutral	-1.6	high_impact	3.62	0.94	neutral	0.35	neutral	1.98	16.11	deleterious	0.24	0.45	0.44	neutral	0.76	disease	0.51	disease	0.55	disease	1	0.25	neutral	0.69	deleterious	-2	neutral	0.29	neutral	-0.31	medium_impact	0.36	medium_impact	2.09	high_impact	0.63	0.8	56.58	8.01	0.47	N	0.87	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15398	15398	A	T	MI.9718	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	652	218	I	F	Atc/Ttc	4.77	1	0	possibly_damaging	0.88	neutral	0.7	neutral	3.03	deleterious	-5.44	deleterious	-3.22	high_impact	4.5	0.95	neutral	0.37	neutral	3.48	23.10	deleterious	0.08	0.35	0.78	disease	0.86	disease	0.69	disease	0.69	disease	4	0.86	neutral	0.41	neutral	1	deleterious	0.81	deleterious	-1.54	low_impact	0.42	medium_impact	2.89	high_impact	0.58	0.8	56.58	8.01	0.58	P	0.97	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15398	15398	A	G	MI.9719	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	652	218	I	V	Atc/Gtc	4.77	1	0	benign	0.01	neutral	0.51	neutral	3.17	neutral	-1.73	neutral	-0.63	low_impact	1.18	0.98	neutral	0.82	neutral	0.04	2.96	deleterious	0.3	0.45	0.28	neutral	0.35	neutral	0.29	neutral	0.4	neutral	2	0.47	neutral	0.75	deleterious	-6	neutral	0.16	neutral	1.13	medium_impact	0.23	medium_impact	-0.12	medium_impact	0.40	0.8	56.58	8.01	0.57	P	0.84	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8982	8982	A	C	MI.972	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	456	152	Q	H	caA/caC	4.99	1	0	probably_damaging	1	deleterious	0	neutral	3.86	neutral	-1.81	deleterious	-2.95	low_impact	1.9	0.79	neutral	0.36	neutral	3.97	23.60	deleterious	0.45	0.65	0.76	disease	0.72	disease	0.59	disease	0.71	disease	4	1	deleterious	0	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	0.53	medium_impact	0.73	0.9	46.9	8.18	0.42	N	0.97	disease_causing	0.97	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15399	15399	T	G	MI.9720	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	653	218	I	S	aTc/aGc	4.54	1	0	probably_damaging	0.99	neutral	0.42	neutral	3.08	deleterious	-5.72	deleterious	-4.75	high_impact	3.81	0.94	neutral	0.37	neutral	4.39	24.10	deleterious	0.02	0.35	0.81	disease	0.89	disease	0.71	disease	0.71	disease	4	0.99	deleterious	0.22	neutral	2	deleterious	0.88	deleterious	-2.59	low_impact	0.15	medium_impact	2.27	high_impact	0.22	0.8	56.58	8.01	0.51	N	0.98	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15399	15399	T	C	MI.9721	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	653	218	I	T	aTc/aCc	4.54	1	0	probably_damaging	0.98	neutral	0.39	neutral	3.08	deleterious	-5.05	deleterious	-3.86	high_impact	3.61	0.94	neutral	0.38	neutral	3.54	23.10	deleterious	0.03	0.35	0.73	disease	0.81	disease	0.59	disease	0.58	disease	2	0.98	neutral	0.21	neutral	2	deleterious	0.83	deleterious	-2.31	low_impact	0.12	medium_impact	2.08	high_impact	0.18	0.8	56.58	8.01	0.47	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15399	15399	T	A	MI.9722	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	653	218	I	N	aTc/aAc	4.54	1	0	probably_damaging	1	neutral	0.32	neutral	3.16	deleterious	-6.9	deleterious	-5.56	high_impact	4.76	0.91	neutral	0.38	neutral	4.63	24.50	deleterious	0.04	0.35	0.9	disease	0.88	disease	0.6	disease	0.66	disease	3	1	deleterious	0.16	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.05	medium_impact	3.13	high_impact	0.27	0.8	56.58	8.01	0.71	P	0.99	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15400	15400	C	G	MI.9723	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	654	218	I	M	atC/atG	3.63	1	0	probably_damaging	0.94	neutral	0.22	neutral	3.04	deleterious	-5.32	neutral	-2.29	high_impact	3.96	0.94	neutral	0.36	neutral	3.29	22.80	deleterious	0.13	0.4	0.76	disease	0.73	disease	0.51	disease	0.5	neutral	0	0.96	neutral	0.14	neutral	2	deleterious	0.69	deleterious	-1.85	low_impact	-0.08	medium_impact	2.4	high_impact	0.56	0.8	56.58	8.01	0.49	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15400	15400	C	A	MI.9724	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	654	218	I	M	atC/atA	3.63	1	0	probably_damaging	0.94	neutral	0.22	neutral	3.04	deleterious	-5.32	neutral	-2.29	high_impact	3.96	0.94	neutral	0.36	neutral	3.72	23.30	deleterious	0.13	0.4	0.76	disease	0.73	disease	0.51	disease	0.5	neutral	0	0.96	neutral	0.14	neutral	2	deleterious	0.69	deleterious	-1.85	low_impact	-0.08	medium_impact	2.4	high_impact	0.56	0.8	56.58	8.01	0.5	N	0.82	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15401	15401	A	C	MI.9725	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	655	219	T	P	Acc/Ccc	-2.8	0	0	possibly_damaging	0.79	neutral	0.24	neutral	3.51	neutral	2.76	neutral	2.82	neutral_impact	-2.52	0.92	neutral	0.94	neutral	0.68	8.72	deleterious	0.05	0.35	0.22	neutral	0.05	neutral	0.14	neutral	0.23	neutral	5	0.86	neutral	0.23	neutral	-3	neutral	0.59	deleterious	-1.27	low_impact	-0.05	medium_impact	-3.48	low_impact	0.25	0.8	25.53	30.43	0.49	N	0.01	polymorphism	1	0.01	rs200521299	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15401	15401	A	G	MI.9726	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	655	219	T	A	Acc/Gcc	-2.8	0	0	benign	0.03	neutral	0.5	neutral	3.19	neutral	0.44	neutral	-0.24	low_impact	1.51	0.81	neutral	0.8	neutral	3.19	22.70	deleterious	0.28	0.45	0.21	neutral	0.25	neutral	0.54	disease	0.42	neutral	2	0.47	neutral	0.74	deleterious	-6	neutral	0.15	neutral	0.68	medium_impact	0.22	medium_impact	0.18	medium_impact	0.29	0.8	25.53	30.43	0.32	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15401	15401	A	T	MI.9727	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	655	219	T	S	Acc/Tcc	-2.8	0	0	benign	0.4	neutral	0.41	neutral	3.21	neutral	0.75	neutral	0.46	neutral_impact	-1.19	0.81	neutral	0.79	neutral	1.87	15.42	deleterious	0.39	0.5	0.26	neutral	0.14	neutral	0.23	neutral	0.29	neutral	4	0.53	neutral	0.51	deleterious	-6	neutral	0.34	neutral	-0.57	medium_impact	0.14	medium_impact	-2.27	low_impact	0.32	0.8	25.53	30.43	0.35	N	0.34	polymorphism	1	0.01	rs200521299	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15402	15402	C	T	MI.9728	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	656	219	T	I	aCc/aTc	0.18	0	0	possibly_damaging	0.66	neutral	0.43	neutral	3.14	neutral	-1.2	neutral	-2.04	low_impact	1.61	0.76	neutral	0.6	neutral	3.96	23.60	deleterious	0.2	0.45	0.24	neutral	0.49	neutral	0.53	disease	0.54	disease	1	0.66	neutral	0.39	neutral	-3	neutral	0.51	deleterious	-1	medium_impact	0.16	medium_impact	0.27	medium_impact	0.39	0.8	25.53	30.43	0.25	N	0.56	polymorphism	1	0.04	rs879163418	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15402	15402	C	G	MI.9729	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	656	219	T	S	aCc/aGc	0.18	0	0	benign	0.4	neutral	0.41	neutral	3.21	neutral	0.75	neutral	0.46	neutral_impact	-1.19	0.81	neutral	0.79	neutral	2.10	16.84	deleterious	0.39	0.5	0.26	neutral	0.14	neutral	0.23	neutral	0.29	neutral	4	0.53	neutral	0.51	deleterious	-6	neutral	0.34	neutral	-0.57	medium_impact	0.14	medium_impact	-2.27	low_impact	0.32	0.8	25.53	30.43	0.38	N	0.34	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8982	8982	A	T	MI.973	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	456	152	Q	H	caA/caT	4.99	1	0	probably_damaging	1	deleterious	0	neutral	3.86	neutral	-1.81	deleterious	-2.95	low_impact	1.9	0.79	neutral	0.36	neutral	4.13	23.80	deleterious	0.45	0.65	0.76	disease	0.72	disease	0.59	disease	0.71	disease	4	1	deleterious	0	neutral	2	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	0.53	medium_impact	0.73	0.9	46.9	8.18	0.43	N	0.97	disease_causing	0.97	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15402	15402	C	A	MI.9730	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	656	219	T	N	aCc/aAc	0.18	0	0	possibly_damaging	0.79	neutral	0.31	neutral	3.17	neutral	-0.02	neutral	-0.77	low_impact	1.26	0.83	neutral	0.63	neutral	3.60	23.20	deleterious	0.36	0.5	0.49	neutral	0.64	disease	0.56	disease	0.68	disease	4	0.82	neutral	0.26	neutral	-3	neutral	0.64	deleterious	-1.27	low_impact	0.03	medium_impact	-0.05	medium_impact	0.41	0.8	25.53	30.43	0.3	N	0.58	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15404	15404	T	A	MI.9731	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	658	220	F	I	Ttc/Atc	-1.88	0	0	probably_damaging	1	neutral	0.4	neutral	2.99	neutral	-1.05	deleterious	-4.88	high_impact	5.27	0.94	neutral	0.49	neutral	4.27	23.90	deleterious	0.06	0.35	0.63	disease	0.74	disease	0.73	disease	0.71	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.13	medium_impact	3.59	high_impact	0.46	0.8	58.16	8.58	0.7	P	0.98	polymorphism	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15404	15404	T	G	MI.9732	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	658	220	F	V	Ttc/Gtc	-1.88	0	0	probably_damaging	1	neutral	0.5	neutral	2.93	neutral	-1.65	deleterious	-5.69	high_impact	4.72	0.95	neutral	0.5	neutral	4.10	23.70	deleterious	0.04	0.35	0.59	disease	0.82	disease	0.81	disease	0.74	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.22	medium_impact	3.09	high_impact	0.27	0.8	58.16	8.58	0.7	P	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15404	15404	T	C	MI.9733	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	658	220	F	L	Ttc/Ctc	-1.88	0	0	probably_damaging	0.99	neutral	0.65	neutral	2.99	neutral	-1.07	deleterious	-4.88	high_impact	4.58	0.95	neutral	0.45	neutral	3.75	23.30	deleterious	0.09	0.35	0.56	disease	0.74	disease	0.72	disease	0.69	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.37	medium_impact	2.97	high_impact	0.65	0.8	58.16	8.58	0.44	N	0.91	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15405	15405	T	G	MI.9734	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	659	220	F	C	tTc/tGc	3.63	1	0	probably_damaging	1	neutral	0.18	neutral	2.83	deleterious	-4.52	deleterious	-6.5	high_impact	5.27	0.94	neutral	0.41	neutral	4.17	23.80	deleterious	0.02	0.35	0.86	disease	0.78	disease	0.82	disease	0.73	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.14	medium_impact	3.59	high_impact	0.16	0.8	58.16	8.58	0.65	P	0.99	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15405	15405	T	C	MI.9735	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	659	220	F	S	tTc/tCc	3.63	1	0	probably_damaging	1	neutral	0.4	neutral	2.86	deleterious	-3.19	deleterious	-6.5	high_impact	4.64	0.96	neutral	0.47	neutral	4.24	23.90	deleterious	0.02	0.35	0.57	disease	0.81	disease	0.81	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	0.13	medium_impact	3.02	high_impact	0.24	0.8	58.16	8.58	0.63	P	0.99	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15405	15405	T	A	MI.9736	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	659	220	F	Y	tTc/tAc	3.63	1	0	probably_damaging	0.99	neutral	1	neutral	2.84	deleterious	-3.65	neutral	-2.44	high_impact	5.27	0.94	neutral	0.45	neutral	3.92	23.50	deleterious	0.1	0.4	0.71	disease	0.72	disease	0.75	disease	0.71	disease	4	0.99	deleterious	0.51	deleterious	2	deleterious	0.84	deleterious	-2.59	low_impact	1.85	high_impact	3.59	high_impact	0.52	0.8	58.16	8.58	0.72	P	0.88	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15406	15406	C	A	MI.9737	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	660	220	F	L	ttC/ttA	5.69	1	0	probably_damaging	0.99	neutral	0.65	neutral	2.99	neutral	-1.07	deleterious	-4.88	high_impact	4.58	0.95	neutral	0.45	neutral	4.34	24.00	deleterious	0.09	0.35	0.56	disease	0.74	disease	0.72	disease	0.69	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.37	medium_impact	2.97	high_impact	0.65	0.8	58.16	8.58	0.62	P	0.91	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15406	15406	C	G	MI.9738	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	660	220	F	L	ttC/ttG	5.69	1	0	probably_damaging	0.99	neutral	0.65	neutral	2.99	neutral	-1.07	deleterious	-4.88	high_impact	4.58	0.95	neutral	0.45	neutral	4.05	23.70	deleterious	0.09	0.35	0.56	disease	0.74	disease	0.72	disease	0.69	disease	4	0.99	deleterious	0.33	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.37	medium_impact	2.97	high_impact	0.65	0.8	58.16	8.58	0.61	P	0.91	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15407	15407	C	G	MI.9739	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	661	221	H	D	Cac/Gac	-1.65	0	0	probably_damaging	1	neutral	0.27	neutral	3.06	deleterious	-5.37	deleterious	-7.27	high_impact	4.76	0.92	neutral	0.32	neutral	3.63	23.20	deleterious	0.04	0.35	0.46	neutral	0.85	disease	0.85	disease	0.76	disease	5	1	deleterious	0.14	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	-0.01	medium_impact	3.13	high_impact	0.24	0.8	57.63	8.82	0.63	P	0.98	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8983	8983	C	T	MI.974	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	457	153	P	S	Cca/Tca	-0.1	0.65	0	probably_damaging	1	deleterious	0	neutral	3.92	deleterious	-3.28	deleterious	-7.03	medium_impact	3.34	0.6	neutral	0.05	damaging	3.93	23.50	deleterious	0.44	0.65	0.73	disease	0.84	disease	0.73	disease	0.74	disease	5	1	deleterious	0	neutral	5	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	1.77	medium_impact	0.29	0.9	49.56	8.78	0.27	N	0.82	disease_causing	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15407	15407	C	T	MI.9740	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	661	221	H	Y	Cac/Tac	-1.65	0	0	probably_damaging	0.99	neutral	1	neutral	3.2	deleterious	-6.95	deleterious	-4.85	medium_impact	3.06	0.97	neutral	0.39	neutral	2.14	17.13	deleterious	0.11	0.4	0.39	neutral	0.84	disease	0.77	disease	0.59	disease	2	0.99	deleterious	0.51	deleterious	1	deleterious	0.80	deleterious	-2.59	low_impact	1.85	high_impact	1.59	medium_impact	0.19	0.8	57.63	8.82	0.33	N	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15407	15407	C	A	MI.9741	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	661	221	H	N	Cac/Aac	-1.65	0	0	probably_damaging	0.99	neutral	0.3	neutral	3.07	deleterious	-5.86	deleterious	-5.64	medium_impact	3.5	0.93	neutral	0.41	neutral	2.31	18.26	deleterious	0.21	0.45	0.42	neutral	0.85	disease	0.79	disease	0.72	disease	4	0.99	deleterious	0.16	neutral	1	deleterious	0.78	deleterious	-2.59	low_impact	0.02	medium_impact	1.98	medium_impact	0.18	0.8	57.63	8.82	0.47	N	0.97	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15408	15408	A	T	MI.9742	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	662	221	H	L	cAc/cTc	5.46	1	0	probably_damaging	0.99	neutral	0.67	neutral	3.2	deleterious	-6.65	deleterious	-8.89	high_impact	3.94	0.95	neutral	0.36	neutral	2.80	21.30	deleterious	0.03	0.35	0.51	disease	0.9	disease	0.83	disease	0.77	disease	5	0.99	deleterious	0.34	neutral	2	deleterious	0.82	deleterious	-2.59	low_impact	0.39	medium_impact	2.38	high_impact	0.12	0.8	57.63	8.82	0.56	P	0.92	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15408	15408	A	C	MI.9743	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	662	221	H	P	cAc/cCc	5.46	1	0	probably_damaging	1	neutral	0.24	neutral	3.09	deleterious	-6.73	deleterious	-8.08	high_impact	4.76	0.94	neutral	0.25	damaging	3.46	23.00	deleterious	0.03	0.35	0.65	disease	0.86	disease	0.79	disease	0.72	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.05	medium_impact	3.13	high_impact	0.10	0.8	57.63	8.82	0.68	P	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15408	15408	A	G	MI.9744	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	662	221	H	R	cAc/cGc	5.46	1	0	probably_damaging	0.99	neutral	0.34	neutral	3.09	deleterious	-6.07	deleterious	-6.46	high_impact	4.91	0.94	neutral	0.31	neutral	1.93	15.75	deleterious	0.07	0.35	0.45	neutral	0.86	disease	0.82	disease	0.73	disease	5	0.99	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-2.59	low_impact	0.07	medium_impact	3.26	high_impact	0.23	0.8	57.63	8.82	0.68	P	0.98	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15409	15409	C	A	MI.9745	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	663	221	H	Q	caC/caA	8.44	1	0	probably_damaging	1	neutral	0.28	neutral	3.07	deleterious	-6.2	deleterious	-6.46	high_impact	4.76	0.96	neutral	0.37	neutral	2.35	18.46	deleterious	0.11	0.4	0.31	neutral	0.82	disease	0.79	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0	medium_impact	3.13	high_impact	0.26	0.8	57.63	8.82	0.65	P	0.94	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15409	15409	C	G	MI.9746	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	663	221	H	Q	caC/caG	8.44	1	0	probably_damaging	1	neutral	0.28	neutral	3.07	deleterious	-6.2	deleterious	-6.46	high_impact	4.76	0.96	neutral	0.37	neutral	2.07	16.64	deleterious	0.11	0.4	0.31	neutral	0.82	disease	0.79	disease	0.71	disease	4	1	deleterious	0.14	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0	medium_impact	3.13	high_impact	0.26	0.8	57.63	8.82	0.65	P	0.94	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15410	15410	C	T	MI.9747	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	664	222	P	S	Cct/Tct	0.18	0.98	0	probably_damaging	1	neutral	0.4	neutral	2.49	deleterious	-4.72	deleterious	-6.4	medium_impact	3.11	0.75	neutral	0.47	neutral	3.86	23.50	deleterious	0.07	0.35	0.43	neutral	0.82	disease	0.39	neutral	0.49	neutral	0	1	deleterious	0.2	neutral	1	deleterious	0.82	deleterious	-3.53	low_impact	0.13	medium_impact	1.63	medium_impact	0.17	0.8	57.37	8.69	0.43	N	0.85	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15410	15410	C	A	MI.9748	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	664	222	P	T	Cct/Act	0.18	0.98	0	probably_damaging	1	neutral	0.38	neutral	2.49	deleterious	-5.15	deleterious	-6.39	medium_impact	2.86	0.81	neutral	0.45	neutral	3.87	23.50	deleterious	0.06	0.35	0.66	disease	0.82	disease	0.56	disease	0.52	disease	0	1	deleterious	0.19	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.11	medium_impact	1.4	medium_impact	0.46	0.8	57.37	8.69	0.34	N	0.96	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15410	15410	C	G	MI.9749	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	664	222	P	A	Cct/Gct	0.18	0.98	0	probably_damaging	1	neutral	0.5	neutral	2.49	deleterious	-4.41	deleterious	-6.4	high_impact	4.29	0.83	neutral	0.51	neutral	2.97	22.10	deleterious	0.08	0.35	0.59	disease	0.63	disease	0.73	disease	0.62	disease	2	1	deleterious	0.25	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.22	medium_impact	2.7	high_impact	0.56	0.8	57.37	8.69	0.47	N	0.82	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8983	8983	C	A	MI.975	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	457	153	P	T	Cca/Aca	-0.1	0.65	0	probably_damaging	1	deleterious	0	neutral	4	neutral	-2.07	deleterious	-7.03	high_impact	3.59	0.61	neutral	0.04	damaging	3.90	23.50	deleterious	0.32	0.65	0.54	disease	0.79	disease	0.72	disease	0.72	disease	4	1	deleterious	0	neutral	6	deleterious	0.80	deleterious	-3.6	low_impact	-1.4	low_impact	1.98	medium_impact	0.77	0.9	49.56	8.78	0.28	N	0.93	disease_causing	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15411	15411	C	T	MI.9750	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	665	222	P	L	cCt/cTt	7.07	1	0	probably_damaging	1	neutral	0.65	neutral	2.47	deleterious	-5.62	deleterious	-8.03	high_impact	4.36	0.83	neutral	0.38	neutral	4.38	24.10	deleterious	0.04	0.35	0.76	disease	0.88	disease	0.71	disease	0.71	disease	4	1	deleterious	0.33	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.37	medium_impact	2.77	high_impact	0.72	0.85	57.37	8.69	0.57	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15411	15411	C	G	MI.9751	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	665	222	P	R	cCt/cGt	7.07	1	0	probably_damaging	1	neutral	0.34	neutral	2.47	deleterious	-4.95	deleterious	-7.23	high_impact	5.11	0.83	neutral	0.37	neutral	3.71	23.30	deleterious	0.03	0.35	0.67	disease	0.89	disease	0.82	disease	0.76	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.07	medium_impact	3.45	high_impact	0.48	0.8	57.37	8.69	0.71	P	0.81	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15411	15411	C	A	MI.9752	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	665	222	P	H	cCt/cAt	7.07	1	0	probably_damaging	1	neutral	0.56	neutral	2.44	deleterious	-6.23	deleterious	-7.23	high_impact	4.55	0.78	neutral	0.33	neutral	4.07	23.70	deleterious	0.04	0.35	0.8	disease	0.85	disease	0.7	disease	0.69	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.28	medium_impact	2.94	high_impact	0.31	0.8	57.37	8.69	0.52	N	0.71	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15413	15413	T	A	MI.9753	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	667	223	Y	N	Tac/Aac	-20	0	0	probably_damaging	1	neutral	0.3	neutral	3.12	deleterious	-5.22	deleterious	-7.23	high_impact	4.19	0.92	neutral	0.13	damaging	4.07	23.70	deleterious	0.05	0.35	0.49	neutral	0.89	disease	0.83	disease	0.77	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.02	medium_impact	2.61	high_impact	0.07	0.8	58.95	8.71	0.45	N	0.99	polymorphism	1	0.25	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15413	15413	T	G	MI.9754	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	667	223	Y	D	Tac/Gac	-20	0	0	probably_damaging	1	neutral	0.21	neutral	3.13	deleterious	-5.99	deleterious	-8.02	high_impact	4.96	0.9	neutral	0.1	damaging	4.04	23.70	deleterious	0.02	0.35	0.61	disease	0.9	disease	0.86	disease	0.78	disease	6	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.09	medium_impact	3.31	high_impact	0.11	0.8	58.95	8.71	0.62	P	1.00	disease_causing	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15413	15413	T	C	MI.9755	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	667	223	Y	H	Tac/Cac	-20	0	0	probably_damaging	1	neutral	0.53	neutral	3.1	deleterious	-4.85	deleterious	-4.02	high_impact	3.86	0.92	neutral	0.09	damaging	3.57	23.10	deleterious	0.1	0.4	0.73	disease	0.82	disease	0.86	disease	0.76	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.87	deleterious	-3.53	low_impact	0.25	medium_impact	2.31	high_impact	0.17	0.8	58.95	8.71	0.29	N	0.98	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15414	15414	A	G	MI.9756	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	668	223	Y	C	tAc/tGc	5.69	1	0	probably_damaging	1	neutral	0.17	neutral	3.09	deleterious	-4.47	deleterious	-7.21	high_impact	5.16	0.94	neutral	0.07	damaging	3.61	23.20	deleterious	0.04	0.35	0.84	disease	0.87	disease	0.83	disease	0.74	disease	5	1	deleterious	0.09	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.15	medium_impact	3.49	high_impact	0.10	0.8	58.95	8.71	0.73	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15414	15414	A	T	MI.9757	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	668	223	Y	F	tAc/tTc	5.69	1	0	probably_damaging	1	neutral	0.69	neutral	3.06	neutral	0.1	deleterious	-3.1	medium_impact	2.75	0.95	neutral	0.11	damaging	1.94	15.80	deleterious	0.18	0.45	0.7	disease	0.8	disease	0.56	disease	0.47	neutral	1	1	deleterious	0.35	neutral	1	deleterious	0.84	deleterious	-3.53	low_impact	0.41	medium_impact	1.3	medium_impact	0.37	0.8	58.95	8.71	0.43	N	0.83	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15414	15414	A	C	MI.9758	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	668	223	Y	S	tAc/tCc	5.69	1	0	probably_damaging	1	neutral	0.38	neutral	3.12	deleterious	-4.38	deleterious	-7.21	high_impact	4.61	0.92	neutral	0.11	damaging	3.70	23.30	deleterious	0.04	0.35	0.53	disease	0.87	disease	0.8	disease	0.74	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.11	medium_impact	2.99	high_impact	0.13	0.8	58.95	8.71	0.64	P	1.00	polymorphism	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15416	15416	T	A	MI.9759	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	670	224	Y	N	Tac/Aac	-0.5	0.15	0	probably_damaging	0.96	neutral	0.21	neutral	3.31	neutral	-2.98	deleterious	-5.79	high_impact	4.51	0.92	neutral	0.47	neutral	4.23	23.90	deleterious	0.03	0.35	0.88	disease	0.89	disease	0.72	disease	0.79	disease	6	0.97	neutral	0.13	neutral	2	deleterious	0.88	deleterious	-2.02	low_impact	-0.09	medium_impact	2.9	high_impact	0.27	0.8	45.53	8.25	0.55	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8983	8983	C	G	MI.976	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	457	153	P	A	Cca/Gca	-0.1	0.65	0	probably_damaging	1	neutral	0.08	neutral	4.03	neutral	-1.79	deleterious	-7.03	medium_impact	2.26	0.59	damaging	0.07	damaging	3.14	22.60	deleterious	0.27	0.65	0.32	neutral	0.64	disease	0.73	disease	0.6	disease	2	1	deleterious	0.04	neutral	1	deleterious	0.73	deleterious	-3.6	low_impact	-0.31	medium_impact	0.84	medium_impact	0.72	0.9	49.56	8.78	0.26	N	0.79	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15416	15416	T	G	MI.9760	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	670	224	Y	D	Tac/Gac	-0.5	0.15	0	probably_damaging	0.98	neutral	0.19	neutral	3.12	deleterious	-3.29	deleterious	-6.1	high_impact	4.51	0.9	neutral	0.37	neutral	3.98	23.60	deleterious	0.02	0.35	0.93	disease	0.91	disease	0.82	disease	0.84	disease	7	0.98	deleterious	0.11	neutral	2	deleterious	0.90	deleterious	-2.31	low_impact	-0.12	medium_impact	2.9	high_impact	0.20	0.8	45.53	8.25	0.62	P	1.00	disease_causing	1	0.39	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15416	15416	T	C	MI.9761	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	670	224	Y	H	Tac/Cac	-0.5	0.15	0	probably_damaging	0.98	neutral	0.36	neutral	3.12	neutral	-2.57	deleterious	-3.54	medium_impact	2.99	0.94	neutral	0.6	neutral	2.55	19.78	deleterious	0.08	0.35	0.81	disease	0.77	disease	0.64	disease	0.7	disease	4	0.98	deleterious	0.19	neutral	1	deleterious	0.87	deleterious	-2.31	low_impact	0.09	medium_impact	1.52	medium_impact	0.34	0.8	45.53	8.25	0.37	N	0.98	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15417	15417	A	C	MI.9762	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	671	224	Y	S	tAc/tCc	3.63	0.97	0	possibly_damaging	0.83	neutral	0.34	neutral	3.15	neutral	-2.22	deleterious	-5.29	high_impact	3.62	0.93	neutral	0.5	neutral	3.70	23.30	deleterious	0.03	0.35	0.84	disease	0.84	disease	0.72	disease	0.77	disease	5	0.85	neutral	0.26	neutral	1	deleterious	0.84	deleterious	-1.37	low_impact	0.07	medium_impact	2.09	high_impact	0.36	0.8	45.53	8.25	0.54	N	1.00	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15417	15417	A	G	MI.9763	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	671	224	Y	C	tAc/tGc	3.63	0.97	0	benign	0.1	neutral	0.11	neutral	3.09	deleterious	-3.87	deleterious	-5.29	high_impact	4.51	0.92	neutral	0.45	neutral	3.61	23.20	deleterious	0.02	0.35	0.92	disease	0.89	disease	0.76	disease	0.83	disease	7	0.88	neutral	0.51	deleterious	-2	neutral	0.38	neutral	0.16	medium_impact	-0.27	medium_impact	2.9	high_impact	0.17	0.8	45.53	8.25	0.54	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15417	15417	A	T	MI.9764	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	671	224	Y	F	tAc/tTc	3.63	0.97	0	possibly_damaging	0.72	neutral	0.81	neutral	3.28	neutral	0.71	neutral	0.26	neutral_impact	-0.68	0.96	neutral	0.68	neutral	1.39	12.73	neutral	0.19	0.45	0.24	neutral	0.14	neutral	0.25	neutral	0.25	neutral	5	0.67	neutral	0.55	deleterious	-3	neutral	0.59	deleterious	-1.11	low_impact	0.56	medium_impact	-1.81	low_impact	0.58	0.8	45.53	8.25	0.43	N	0.83	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15419	15419	A	C	MI.9765	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	673	225	T	P	Aca/Cca	-3.26	0	0	probably_damaging	1	neutral	0.22	neutral	3.04	deleterious	-3.13	neutral	-2.38	high_impact	3.87	0.98	neutral	0.32	neutral	3.44	23.00	deleterious	0.03	0.35	0.69	disease	0.91	disease	0.46	neutral	0.71	disease	4	1	deleterious	0.11	neutral	2	deleterious	0.86	deleterious	-3.53	low_impact	-0.08	medium_impact	2.32	high_impact	0.43	0.8	57.11	8.35	0.46	N	0.96	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15419	15419	A	T	MI.9766	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	673	225	T	S	Aca/Tca	-3.26	0	0	probably_damaging	0.99	neutral	0.49	neutral	3.11	neutral	-0.66	neutral	0.47	neutral_impact	-0.33	0.96	neutral	0.83	neutral	-0.23	0.95	neutral	0.17	0.45	0.29	neutral	0.08	neutral	0.19	neutral	0.31	neutral	4	0.99	deleterious	0.25	neutral	-2	neutral	0.66	deleterious	-2.59	low_impact	0.21	medium_impact	-1.49	low_impact	0.63	0.8	57.11	8.35	0.49	N	0.79	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15419	15419	A	G	MI.9767	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	673	225	T	A	Aca/Gca	-3.26	0	0	probably_damaging	0.99	neutral	0.37	neutral	3.22	neutral	0.57	neutral	-1.31	medium_impact	2.77	0.98	neutral	0.53	neutral	1.77	14.82	neutral	0.1	0.4	0.38	neutral	0.61	disease	0.65	disease	0.6	disease	2	0.99	deleterious	0.19	neutral	1	deleterious	0.73	deleterious	-2.59	low_impact	0.1	medium_impact	1.32	medium_impact	0.35	0.8	57.11	8.35	0.38	N	0.60	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15420	15420	C	A	MI.9768	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	674	225	T	K	aCa/aAa	0.87	0.25	0	probably_damaging	1	neutral	0.29	neutral	3.05	neutral	-2.47	neutral	-2.1	high_impact	4.57	0.94	neutral	0.35	neutral	4.30	24.00	deleterious	0.04	0.35	0.49	neutral	0.89	disease	0.75	disease	0.76	disease	5	1	deleterious	0.15	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.01	medium_impact	2.96	high_impact	0.41	0.8	57.11	8.35	0.54	N	0.97	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15420	15420	C	T	MI.9769	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	674	225	T	M	aCa/aTa	0.87	0.25	0	probably_damaging	1	neutral	0.22	neutral	3.14	neutral	-0.26	deleterious	-2.61	medium_impact	3.21	0.94	neutral	0.43	neutral	4.07	23.70	deleterious	0.05	0.35	0.54	disease	0.8	disease	0.51	disease	0.64	disease	3	1	deleterious	0.11	neutral	1	deleterious	0.76	deleterious	-3.53	low_impact	-0.08	medium_impact	1.72	medium_impact	0.72	0.85	57.11	8.35	0.36	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8984	8984	C	T	MI.977	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	458	153	P	L	cCa/cTa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	3.98	neutral	-2.27	deleterious	-8.86	high_impact	3.79	0.55	damaging	0.03	damaging	4.41	24.10	deleterious	0.33	0.65	0.83	disease	0.89	disease	0.71	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.85	deleterious	-3.6	low_impact	-1.4	low_impact	2.15	high_impact	0.71	0.9	49.56	8.78	0.5	P	0.95	disease_causing	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15422	15422	A	C	MI.9770	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	676	226	I	L	Atc/Ctc	-4.64	0	0	benign	0.06	neutral	0.65	neutral	3.25	neutral	0.01	neutral	-0.22	low_impact	0.93	0.95	neutral	0.68	neutral	0.89	10.02	neutral	0.18	0.45	0.28	neutral	0.68	disease	0.17	neutral	0.39	neutral	2	0.27	neutral	0.8	deleterious	-6	neutral	0.16	neutral	0.38	medium_impact	0.37	medium_impact	-0.35	medium_impact	0.58	0.8	21.05	14.45	0.38	N	0.63	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15422	15422	A	T	MI.9771	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	676	226	I	F	Atc/Ttc	-4.64	0	0	possibly_damaging	0.58	neutral	0.7	neutral	3.12	neutral	-2.81	neutral	1.38	neutral_impact	0.68	0.97	neutral	0.67	neutral	2.50	19.45	deleterious	0.13	0.4	0.27	neutral	0.73	disease	0.17	neutral	0.42	neutral	2	0.5	neutral	0.56	deleterious	-3	neutral	0.45	deleterious	-0.86	medium_impact	0.42	medium_impact	-0.58	medium_impact	0.59	0.8	21.05	14.45	0.33	N	0.88	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15422	15422	A	G	MI.9772	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	676	226	I	V	Atc/Gtc	-4.64	0	0	benign	0	neutral	0.5	neutral	3.3	neutral	-1.53	neutral	-0.25	low_impact	1.48	0.97	neutral	0.77	neutral	0.18	4.45	deleterious	0.28	0.45	0.28	neutral	0.5	neutral	0.21	neutral	0.4	neutral	2	0.5	neutral	0.75	deleterious	-6	neutral	0.12	neutral	2.07	high_impact	0.22	medium_impact	0.15	medium_impact	0.34	0.8	21.05	14.45	0.37	N	0.51	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15423	15423	T	G	MI.9773	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	677	226	I	S	aTc/aGc	0.17	0	0	benign	0.36	neutral	0.41	neutral	3.08	neutral	-1.5	neutral	-1.77	medium_impact	2.38	0.94	neutral	0.4	neutral	4.15	23.80	deleterious	0.03	0.35	0.35	neutral	0.83	disease	0.28	neutral	0.64	disease	3	0.52	neutral	0.53	deleterious	-3	neutral	0.43	neutral	-0.5	medium_impact	0.14	medium_impact	0.97	medium_impact	0.28	0.8	21.05	14.45	0.33	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15423	15423	T	C	MI.9774	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	677	226	I	T	aTc/aCc	0.17	0	0	benign	0.01	neutral	0.39	neutral	3.09	neutral	-1.62	neutral	-1.36	low_impact	1.6	0.99	neutral	0.86	neutral	2.06	16.58	deleterious	0.09	0.35	0.42	neutral	0.57	disease	0.24	neutral	0.4	neutral	2	0.6	neutral	0.69	deleterious	-6	neutral	0.18	neutral	1.13	medium_impact	0.12	medium_impact	0.26	medium_impact	0.28	0.8	21.05	14.45	0.39	N	0.68	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15423	15423	T	A	MI.9775	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	677	226	I	N	aTc/aAc	0.17	0	0	possibly_damaging	0.62	neutral	0.31	neutral	3.08	neutral	-2.08	neutral	-2.15	medium_impact	2.79	0.93	neutral	0.41	neutral	4.50	24.30	deleterious	0.06	0.35	0.35	neutral	0.9	disease	0.47	neutral	0.64	disease	3	0.72	neutral	0.35	neutral	0	NA	0.60	deleterious	-0.93	medium_impact	0.03	medium_impact	1.34	medium_impact	0.19	0.8	21.05	14.45	0.37	N	1.00	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15424	15424	C	A	MI.9776	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	678	226	I	M	atC/atA	1.31	0	0	possibly_damaging	0.75	neutral	0.22	neutral	3.07	neutral	-2.7	neutral	-0.47	medium_impact	2.29	0.95	neutral	0.55	neutral	3.59	23.20	deleterious	0.18	0.45	0.52	disease	0.63	disease	0.21	neutral	0.42	neutral	2	0.85	neutral	0.24	neutral	0	NA	0.52	deleterious	-1.18	low_impact	-0.08	medium_impact	0.89	medium_impact	0.57	0.8	21.05	14.45	0.43	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15424	15424	C	G	MI.9777	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	678	226	I	M	atC/atG	1.31	0	0	possibly_damaging	0.75	neutral	0.22	neutral	3.07	neutral	-2.7	neutral	-0.47	medium_impact	2.29	0.95	neutral	0.55	neutral	3.13	22.60	deleterious	0.18	0.45	0.52	disease	0.63	disease	0.21	neutral	0.42	neutral	2	0.85	neutral	0.24	neutral	0	NA	0.52	deleterious	-1.18	low_impact	-0.08	medium_impact	0.89	medium_impact	0.57	0.8	21.05	14.45	0.43	N	0.77	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15425	15425	A	G	MI.9778	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	679	227	K	E	Aaa/Gaa	-9.46	0	0	possibly_damaging	0.46	neutral	0.27	neutral	2.86	neutral	-2.28	deleterious	-3.24	high_impact	4.69	0.73	neutral	0.13	damaging	3.88	23.50	deleterious	0.1	0.4	0.6	disease	0.88	disease	0.77	disease	0.74	disease	5	0.69	neutral	0.41	neutral	1	deleterious	0.68	deleterious	-0.67	medium_impact	-0.01	medium_impact	3.07	high_impact	0.42	0.8	57.89	8.77	0.61	P	0.95	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15425	15425	A	C	MI.9779	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	679	227	K	Q	Aaa/Caa	-9.46	0	0	benign	0.02	neutral	0.29	neutral	2.84	neutral	-2.97	deleterious	-3.23	high_impact	4.43	0.82	neutral	0.17	damaging	3.18	22.70	deleterious	0.19	0.45	0.63	disease	0.83	disease	0.71	disease	0.72	disease	4	0.7	neutral	0.64	deleterious	-2	neutral	0.31	neutral	0.85	medium_impact	0.01	medium_impact	2.83	high_impact	0.43	0.8	57.89	8.77	0.42	N	0.93	polymorphism	1	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8984	8984	C	G	MI.978	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	458	153	P	R	cCa/cGa	7.3	1	0	probably_damaging	1	deleterious	0.01	neutral	3.88	deleterious	-4.49	deleterious	-7.97	high_impact	4.49	0.61	neutral	0.04	damaging	3.64	23.20	deleterious	0.21	0.65	0.82	disease	0.9	disease	0.8	disease	0.8	disease	6	1	deleterious	0.01	neutral	6	deleterious	0.88	deleterious	-3.6	low_impact	-0.84	medium_impact	2.75	high_impact	0.57	0.9	49.56	8.78	0.54	P	0.65	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15426	15426	A	C	MI.9780	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	680	227	K	T	aAa/aCa	6.81	1	0	possibly_damaging	0.8	neutral	0.39	neutral	2.82	deleterious	-3.75	deleterious	-4.85	high_impact	5.24	0.84	neutral	0.14	damaging	3.72	23.30	deleterious	0.05	0.35	0.67	disease	0.83	disease	0.72	disease	0.71	disease	4	0.81	neutral	0.3	neutral	1	deleterious	0.78	deleterious	-1.29	low_impact	0.12	medium_impact	3.56	high_impact	0.24	0.8	57.89	8.77	0.74	P	0.88	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15426	15426	A	T	MI.9781	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	680	227	K	M	aAa/aTa	6.81	1	0	probably_damaging	0.95	neutral	0.22	neutral	2.78	deleterious	-6.1	deleterious	-4.86	high_impact	4.89	0.85	neutral	0.15	damaging	4.01	23.60	deleterious	0.05	0.35	0.83	disease	0.86	disease	0.71	disease	0.69	disease	4	0.97	neutral	0.14	neutral	2	deleterious	0.80	deleterious	-1.92	low_impact	-0.08	medium_impact	3.25	high_impact	0.13	0.8	57.89	8.77	0.73	P	0.67	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15427	15427	A	T	MI.9782	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	681	227	K	N	aaA/aaT	8.42	1	0	possibly_damaging	0.74	neutral	0.31	neutral	2.84	neutral	-2.94	deleterious	-4.05	high_impact	4.55	0.82	neutral	0.13	damaging	3.90	23.50	deleterious	0.17	0.45	0.55	disease	0.86	disease	0.72	disease	0.72	disease	4	0.79	neutral	0.29	neutral	1	deleterious	0.77	deleterious	-1.16	low_impact	0.03	medium_impact	2.94	high_impact	0.29	0.8	57.89	8.77	0.64	P	0.84	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15427	15427	A	C	MI.9783	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	681	227	K	N	aaA/aaC	8.42	1	0	possibly_damaging	0.74	neutral	0.31	neutral	2.84	neutral	-2.94	deleterious	-4.05	high_impact	4.55	0.82	neutral	0.13	damaging	3.82	23.40	deleterious	0.17	0.45	0.55	disease	0.86	disease	0.72	disease	0.72	disease	4	0.79	neutral	0.29	neutral	1	deleterious	0.77	deleterious	-1.16	low_impact	0.03	medium_impact	2.94	high_impact	0.29	0.8	57.89	8.77	0.62	P	0.84	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15428	15428	G	A	MI.9784	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	682	228	D	N	Gac/Aac	1.31	1	0	probably_damaging	1	neutral	0.31	neutral	3.02	deleterious	-3.15	deleterious	-4.04	high_impact	5.07	0.88	neutral	0.13	damaging	4.26	23.90	deleterious	0.34	0.5	0.47	neutral	0.86	disease	0.7	disease	0.72	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.03	medium_impact	3.41	high_impact	0.71	0.85	56.58	8.57	0.67	P	0.99	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15428	15428	G	T	MI.9785	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	682	228	D	Y	Gac/Tac	1.31	1	0	probably_damaging	1	neutral	1	neutral	2.96	deleterious	-5.52	deleterious	-7.27	high_impact	5.62	0.92	neutral	0.11	damaging	3.97	23.60	deleterious	0.02	0.35	0.92	disease	0.94	disease	0.75	disease	0.74	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.90	deleterious	-3.53	low_impact	1.85	high_impact	3.91	high_impact	0.06	0.8	56.58	8.57	0.62	P	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15428	15428	G	C	MI.9786	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	682	228	D	H	Gac/Cac	1.31	1	0	probably_damaging	1	neutral	0.54	neutral	2.97	deleterious	-4.55	deleterious	-5.66	high_impact	5.27	0.91	neutral	0.1	damaging	3.65	23.20	deleterious	0.05	0.35	0.85	disease	0.89	disease	0.76	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.26	medium_impact	3.59	high_impact	0.30	0.8	56.58	8.57	0.67	P	1.00	polymorphism	1	0.50	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15429	15429	A	C	MI.9787	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	683	228	D	A	gAc/gCc	5.9	1	0	probably_damaging	1	neutral	0.5	neutral	3.05	deleterious	-3.25	deleterious	-6.47	high_impact	5.62	0.93	neutral	0.13	damaging	3.58	23.20	deleterious	0.04	0.35	0.73	disease	0.83	disease	0.72	disease	0.71	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.22	medium_impact	3.91	high_impact	0.17	0.8	56.58	8.57	0.7	P	0.95	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15429	15429	A	T	MI.9788	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	683	228	D	V	gAc/gTc	5.9	1	0	probably_damaging	1	neutral	0.5	neutral	2.98	deleterious	-4.64	deleterious	-7.27	high_impact	5.27	0.92	neutral	0.12	damaging	3.72	23.30	deleterious	0.02	0.35	0.87	disease	0.92	disease	0.71	disease	0.73	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.22	medium_impact	3.59	high_impact	0.04	0.8	56.58	8.57	0.71	P	1.00	polymorphism	1	0.51	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15429	15429	A	G	MI.9789	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	683	228	D	G	gAc/gGc	5.9	1	0	probably_damaging	1	neutral	0.33	neutral	2.99	deleterious	-3.94	deleterious	-5.66	high_impact	4.3	0.92	neutral	0.14	damaging	3.95	23.60	deleterious	0.04	0.35	0.77	disease	0.88	disease	0.68	disease	0.72	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	0.06	medium_impact	2.71	high_impact	0.20	0.8	56.58	8.57	0.6	P	1.00	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8984	8984	C	A	MI.979	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	458	153	P	Q	cCa/cAa	7.3	1	0	probably_damaging	1	deleterious	0	neutral	3.88	deleterious	-4.48	deleterious	-7.08	high_impact	4.49	0.58	damaging	0.04	damaging	4.23	23.90	deleterious	0.22	0.65	0.8	disease	0.87	disease	0.72	disease	0.76	disease	5	1	deleterious	0	neutral	6	deleterious	0.84	deleterious	-3.6	low_impact	-1.4	low_impact	2.75	high_impact	0.51	0.9	49.56	8.78	0.47	N	0.82	disease_causing	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15430	15430	C	G	MI.9790	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	684	228	D	E	gaC/gaG	6.59	1	0	probably_damaging	0.99	neutral	0.27	neutral	3.05	neutral	-2.27	deleterious	-3.23	high_impact	4.72	0.91	neutral	0.13	damaging	3.57	23.20	deleterious	0.13	0.4	0.46	neutral	0.82	disease	0.64	disease	0.67	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	-0.01	medium_impact	3.09	high_impact	0.36	0.8	56.58	8.57	0.69	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15430	15430	C	A	MI.9791	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	684	228	D	E	gaC/gaA	6.59	1	0	probably_damaging	0.99	neutral	0.27	neutral	3.05	neutral	-2.27	deleterious	-3.23	high_impact	4.72	0.91	neutral	0.13	damaging	3.92	23.50	deleterious	0.13	0.4	0.46	neutral	0.82	disease	0.64	disease	0.67	disease	3	1	deleterious	0.14	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	-0.01	medium_impact	3.09	high_impact	0.36	0.8	56.58	8.57	0.7	P	1.00	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15431	15431	G	C	MI.9792	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	685	229	A	P	Gcc/Ccc	-1.44	0	0.01	possibly_damaging	0.71	neutral	0.2	neutral	3.1	neutral	-2.19	neutral	-1.76	medium_impact	2.29	0.94	neutral	0.39	neutral	3.83	23.40	deleterious	0.04	0.35	0.66	disease	0.83	disease	0.68	disease	0.78	disease	6	0.84	neutral	0.25	neutral	0	NA	0.65	deleterious	-1.09	low_impact	-0.1	medium_impact	0.89	medium_impact	0.54	0.8	20	21.64	0.36	N	0.38	polymorphism	1	0.08	rs193302993	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	15431	15431	G	A	MI.9793	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	685	229	A	T	Gcc/Acc	-1.44	0	0.01	benign	0.18	neutral	0.4	neutral	3.19	neutral	-0.39	neutral	-0.22	low_impact	1.1	0.97	neutral	0.74	neutral	3.07	22.40	deleterious	0.16	0.45	0.38	neutral	0.3	neutral	0.26	neutral	0.47	neutral	1	0.52	neutral	0.61	deleterious	-6	neutral	0.15	neutral	-0.12	medium_impact	0.13	medium_impact	-0.2	medium_impact	0.58	0.8	20	21.64	0.51	N	0.12	polymorphism	1	0.01	rs193302993,rs527236208	Likely_pathogenic	Neoplasm_of_ovary	153647	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	2.97	.	.	.	.	.	.	P	.	P	neutral
chrM	15431	15431	G	T	MI.9794	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	685	229	A	S	Gcc/Tcc	-1.44	0	0.01	benign	0.3	neutral	0.41	neutral	3.14	neutral	1.88	neutral	-0.9	low_impact	1.25	0.95	neutral	0.69	neutral	3.49	23.10	deleterious	0.24	0.45	0.43	neutral	0.4	neutral	0.52	disease	0.48	neutral	0	0.51	neutral	0.56	deleterious	-6	neutral	0.22	neutral	-0.39	medium_impact	0.14	medium_impact	-0.06	medium_impact	0.44	0.8	20	21.64	0.37	N	0.22	polymorphism	1	0.02	rs193302993	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	15432	15432	C	T	MI.9795	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	686	229	A	V	gCc/gTc	-1.44	0	0	benign	0.01	neutral	0.54	neutral	3.23	neutral	0.61	neutral	1.64	neutral_impact	0.53	0.98	neutral	0.94	neutral	3.34	22.90	deleterious	0.14	0.4	0.22	neutral	0.48	neutral	0.28	neutral	0.43	neutral	1	0.45	neutral	0.77	deleterious	-6	neutral	0.10	neutral	1.13	medium_impact	0.26	medium_impact	-0.71	medium_impact	0.63	0.8	20	21.64	0.33	N	0.01	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15432	15432	C	G	MI.9796	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	686	229	A	G	gCc/gGc	-1.44	0	0	benign	0.37	neutral	0.36	neutral	3.21	neutral	-1.59	neutral	-2.37	medium_impact	2.06	0.93	neutral	0.59	neutral	3.85	23.40	deleterious	0.18	0.45	0.4	neutral	0.46	neutral	0.52	disease	0.51	disease	0	0.58	neutral	0.5	deleterious	-3	neutral	0.24	neutral	-0.52	medium_impact	0.09	medium_impact	0.68	medium_impact	0.58	0.8	20	21.64	0.36	N	0.40	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15432	15432	C	A	MI.9797	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	686	229	A	D	gCc/gAc	-1.44	0	0	possibly_damaging	0.62	neutral	0.3	neutral	3.1	neutral	-2.17	neutral	-2.29	medium_impact	3.1	0.92	neutral	0.47	neutral	4.51	24.30	deleterious	0.03	0.35	0.72	disease	0.78	disease	0.68	disease	0.76	disease	5	0.73	neutral	0.34	neutral	0	NA	0.44	deleterious	-0.93	medium_impact	0.02	medium_impact	1.62	medium_impact	0.33	0.8	20	21.64	0.35	N	0.36	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15434	15434	C	T	MI.9798	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	688	230	L	F	Ctc/Ttc	-3.96	0	0	probably_damaging	1	neutral	0.62	neutral	3.02	deleterious	-4.05	neutral	-2.46	low_impact	1.68	0.84	neutral	0.65	neutral	3.91	23.50	deleterious	0.18	0.45	0.45	neutral	0.59	disease	0.33	neutral	0.35	neutral	3	1	deleterious	0.31	neutral	-2	neutral	0.71	deleterious	-3.53	low_impact	0.34	medium_impact	0.33	medium_impact	0.66	0.8	47.63	8.12	0.2	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15434	15434	C	A	MI.9799	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	688	230	L	I	Ctc/Atc	-3.96	0	0	probably_damaging	1	neutral	0.67	neutral	3.02	neutral	-2.32	neutral	-1.2	medium_impact	2.64	0.77	neutral	0.46	neutral	3.93	23.50	deleterious	0.33	0.5	0.34	neutral	0.55	disease	0.31	neutral	0.39	neutral	2	1	deleterious	0.34	neutral	1	deleterious	0.68	deleterious	-3.53	low_impact	0.39	medium_impact	1.2	medium_impact	0.52	0.8	47.63	8.12	0.22	N	0.83	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8570	8570	T	G	MI.98	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	44	15	L	R	cTa/cGa	-1.49	0	0	probably_damaging	1	deleterious	0.03	neutral	4.4	deleterious	-3.68	deleterious	-4.3	medium_impact	3.48	0.8	neutral	0.16	damaging	3.93	23.50	deleterious	0.19	0.65	0.81	disease	0.9	disease	0.77	disease	0.85	disease	7	1	deleterious	0.02	neutral	5	deleterious	0.88	deleterious	-3.6	low_impact	-0.56	medium_impact	1.89	medium_impact	0.74	0.9	11.5	26.27	0.34	N	0.85	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8986	8986	A	C	MI.980	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	460	154	M	L	Ata/Cta	-10.28	0	0	benign	0	neutral	1	neutral	4.89	neutral	2.35	neutral	0.02	neutral_impact	-1.8	0.87	neutral	0.95	neutral	-1.16	0.01	neutral	0.44	0.65	0.54	disease	0.17	neutral	0.36	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	1.98	high_impact	-2.64	low_impact	0.70	0.9	15.49	11.76	0.37	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15434	15434	C	G	MI.9800	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	688	230	L	V	Ctc/Gtc	-3.96	0	0	probably_damaging	0.99	neutral	0.54	neutral	3	neutral	-0.76	neutral	-1.83	low_impact	1.42	0.82	neutral	0.5	neutral	3.04	22.40	deleterious	0.26	0.45	0.21	neutral	0.45	neutral	0.29	neutral	0.41	neutral	2	0.99	deleterious	0.28	neutral	-2	neutral	0.66	deleterious	-2.59	low_impact	0.26	medium_impact	0.1	medium_impact	0.51	0.8	47.63	8.12	0.26	N	0.88	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15435	15435	T	A	MI.9801	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	689	230	L	H	cTc/cAc	-0.52	0	0	probably_damaging	1	neutral	0.33	neutral	2.88	deleterious	-5.71	deleterious	-4.89	high_impact	5.06	0.82	neutral	0.33	neutral	4.15	23.80	deleterious	0.06	0.35	0.76	disease	0.79	disease	0.69	disease	0.69	disease	4	1	deleterious	0.17	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.06	medium_impact	3.4	high_impact	0.23	0.8	47.63	8.12	0.67	P	0.95	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15435	15435	T	G	MI.9802	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	689	230	L	R	cTc/cGc	-0.52	0	0	probably_damaging	1	neutral	0.21	neutral	2.9	deleterious	-4.95	deleterious	-4.29	high_impact	5.06	0.84	neutral	0.32	neutral	4.18	23.80	deleterious	0.03	0.35	0.69	disease	0.88	disease	0.73	disease	0.74	disease	5	1	deleterious	0.11	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.09	medium_impact	3.4	high_impact	0.22	0.8	47.63	8.12	0.7	P	0.99	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15435	15435	T	C	MI.9803	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	689	230	L	P	cTc/cCc	-0.52	0	0	probably_damaging	1	neutral	0.12	neutral	2.91	deleterious	-5.58	deleterious	-4.96	high_impact	4.25	0.83	neutral	0.29	neutral	3.93	23.50	deleterious	0.03	0.35	0.75	disease	0.82	disease	0.73	disease	0.71	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.25	medium_impact	2.67	high_impact	0.23	0.8	47.63	8.12	0.4	N	0.99	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15437	15437	G	C	MI.9804	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	691	231	G	R	Ggc/Cgc	-0.75	0	0	probably_damaging	1	neutral	0.24	neutral	3.04	neutral	-2.83	deleterious	-6.12	high_impact	5.12	0.79	neutral	0.22	damaging	3.88	23.50	deleterious	0.03	0.35	0.55	disease	0.89	disease	0.83	disease	0.77	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.85	deleterious	-3.53	low_impact	-0.05	medium_impact	3.46	high_impact	0.54	0.8	57.37	8.89	0.69	P	0.99	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15437	15437	G	A	MI.9805	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	691	231	G	S	Ggc/Agc	-0.75	0	0	probably_damaging	1	neutral	0.31	neutral	3.06	neutral	-1.87	deleterious	-4.51	high_impact	3.84	0.87	neutral	0.34	neutral	4.18	23.80	deleterious	0.08	0.35	0.4	neutral	0.78	disease	0.65	disease	0.68	disease	4	1	deleterious	0.16	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.03	medium_impact	2.29	high_impact	0.68	0.85	57.37	8.89	0.37	N	0.99	polymorphism	1	0.19	rs878853058	Uncertain_significance	not_provided	237206	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15437	15437	G	T	MI.9806	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	691	231	G	C	Ggc/Tgc	-0.75	0	0	probably_damaging	1	neutral	0.19	neutral	3.04	neutral	-2.4	deleterious	-6.87	high_impact	4.57	0.79	neutral	0.22	damaging	4.15	23.80	deleterious	0.04	0.35	0.78	disease	0.86	disease	0.72	disease	0.71	disease	4	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.12	medium_impact	2.96	high_impact	0.14	0.8	57.37	8.89	0.42	N	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15438	15438	G	T	MI.9807	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	692	231	G	V	gGc/gTc	7.27	1	0	probably_damaging	1	neutral	0.44	neutral	3.14	neutral	-0.6	deleterious	-6.84	high_impact	4.02	0.79	neutral	0.35	neutral	3.82	23.40	deleterious	0.04	0.35	0.44	neutral	0.86	disease	0.74	disease	0.72	disease	4	1	deleterious	0.22	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.17	medium_impact	2.46	high_impact	0.11	0.8	57.37	8.89	0.55	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15438	15438	G	C	MI.9808	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	692	231	G	A	gGc/gCc	7.27	1	0	probably_damaging	1	neutral	0.4	neutral	3.09	neutral	-1.16	deleterious	-4.53	high_impact	4.08	0.7	neutral	0.41	neutral	3.15	22.60	deleterious	0.1	0.4	0.41	neutral	0.65	disease	0.67	disease	0.66	disease	3	1	deleterious	0.2	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.13	medium_impact	2.51	high_impact	0.31	0.8	57.37	8.89	0.59	P	0.84	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15438	15438	G	A	MI.9809	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	692	231	G	D	gGc/gAc	7.27	1	0	probably_damaging	1	neutral	0.19	neutral	3.02	deleterious	-3.96	deleterious	-5.36	high_impact	4.92	0.72	neutral	0.28	damaging	3.84	23.40	deleterious	0.03	0.35	0.59	disease	0.88	disease	0.82	disease	0.76	disease	5	1	deleterious	0.1	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	-0.12	medium_impact	3.27	high_impact	0.08	0.8	57.37	8.89	0.77	P	1.00	polymorphism	1	0.40	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8986	8986	A	T	MI.981	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	460	154	M	L	Ata/Tta	-10.28	0	0	benign	0	neutral	1	neutral	4.89	neutral	2.35	neutral	0.02	neutral_impact	-1.8	0.87	neutral	0.95	neutral	-1.02	0.01	neutral	0.44	0.65	0.54	disease	0.17	neutral	0.36	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.13	neutral	2.09	high_impact	1.98	high_impact	-2.64	low_impact	0.70	0.9	15.49	11.76	0.38	N	0.10	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15440	15440	T	A	MI.9810	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	694	232	L	M	Tta/Ata	-14.5	0	0.04	benign	0.09	neutral	0.27	neutral	3.1	neutral	-0.68	neutral	-0.26	neutral_impact	0.6	0.89	neutral	0.9	neutral	2.22	17.63	deleterious	0.23	0.45	0.42	neutral	0.38	neutral	0.21	neutral	0.47	neutral	1	0.7	neutral	0.59	deleterious	-6	neutral	0.17	neutral	0.21	medium_impact	-0.01	medium_impact	-0.65	medium_impact	0.54	0.8	19.74	19.02	0.49	N	0.52	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15440	15440	T	G	MI.9811	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	694	232	L	V	Tta/Gta	-14.5	0	0.04	benign	0.09	neutral	0.58	neutral	3.21	neutral	0.19	neutral	-0.57	neutral_impact	0.54	0.96	neutral	0.96	neutral	-0.15	1.40	neutral	0.19	0.45	0.19	neutral	0.32	neutral	0.23	neutral	0.44	neutral	1	0.33	neutral	0.75	deleterious	-6	neutral	0.15	neutral	0.21	medium_impact	0.3	medium_impact	-0.7	medium_impact	0.57	0.8	19.74	19.02	0.38	N	0.09	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15441	15441	T	G	MI.9812	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	695	232	L	W	tTa/tGa	-3.96	0	0	probably_damaging	0.96	neutral	0.2	neutral	3.02	deleterious	-3.49	neutral	-0.93	medium_impact	2.48	0.84	neutral	0.45	neutral	3.79	23.40	deleterious	0.06	0.35	0.54	disease	0.74	disease	0.41	neutral	0.51	disease	0	0.98	neutral	0.12	neutral	1	deleterious	0.73	deleterious	-2.02	low_impact	-0.1	medium_impact	1.06	medium_impact	0.19	0.8	19.74	19.02	0.34	N	0.60	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15441	15441	T	C	MI.9813	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	695	232	L	S	tTa/tCa	-3.96	0	0	possibly_damaging	0.77	neutral	0.4	neutral	3.13	neutral	-0.42	neutral	-1.82	medium_impact	2.21	0.89	neutral	0.62	neutral	3.64	23.20	deleterious	0.07	0.35	0.45	neutral	0.54	disease	0.51	disease	0.54	disease	1	0.78	neutral	0.32	neutral	0	NA	0.66	deleterious	-1.22	low_impact	0.13	medium_impact	0.81	medium_impact	0.21	0.8	19.74	19.02	0.33	N	0.30	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15442	15442	A	T	MI.9814	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	696	232	L	F	ttA/ttT	0.86	0	0.01	possibly_damaging	0.44	neutral	1	neutral	3.3	neutral	0.87	neutral	1.97	neutral_impact	-1.52	0.92	neutral	0.88	neutral	0.59	8.08	deleterious	0.21	0.45	0.25	neutral	0.05	neutral	0.17	neutral	0.22	neutral	6	0.44	neutral	0.78	deleterious	-3	neutral	0.48	deleterious	-0.63	medium_impact	1.85	high_impact	-2.57	low_impact	0.51	0.8	19.74	19.02	0.33	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15442	15442	A	C	MI.9815	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	696	232	L	F	ttA/ttC	0.86	0	0.01	possibly_damaging	0.44	neutral	1	neutral	3.3	neutral	0.87	neutral	1.97	neutral_impact	-1.52	0.92	neutral	0.88	neutral	0.46	7.13	deleterious	0.21	0.45	0.25	neutral	0.05	neutral	0.17	neutral	0.22	neutral	6	0.44	neutral	0.78	deleterious	-3	neutral	0.48	deleterious	-0.63	medium_impact	1.85	high_impact	-2.57	low_impact	0.51	0.8	19.74	19.02	0.32	N	0.42	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15443	15443	C	A	MI.9816	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	697	233	L	I	Ctt/Att	-10.83	0	0	benign	0.36	neutral	0.64	neutral	2.98	neutral	-1.07	neutral	0.16	neutral_impact	0.06	0.94	neutral	0.96	neutral	2.12	16.97	deleterious	0.27	0.45	0.36	neutral	0.12	neutral	0.18	neutral	0.29	neutral	4	0.3	neutral	0.64	deleterious	-6	neutral	0.14	neutral	-0.5	medium_impact	0.36	medium_impact	-1.14	low_impact	0.45	0.8	27.11	30.06	0.45	N	0.04	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15443	15443	C	T	MI.9817	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	697	233	L	F	Ctt/Ttt	-10.83	0	0	benign	0.03	neutral	1	neutral	2.97	neutral	-1.12	neutral	-1.23	low_impact	0.93	0.98	neutral	0.94	neutral	2.52	19.57	deleterious	0.22	0.45	0.25	neutral	0.33	neutral	0.3	neutral	0.44	neutral	1	0.03	neutral	0.99	deleterious	-6	neutral	0.10	neutral	0.68	medium_impact	1.85	high_impact	-0.35	medium_impact	0.50	0.8	27.11	30.06	0.33	N	0.09	polymorphism	1	0.03	.	.	.	.	.	.	COSM6716243	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15443	15443	C	G	MI.9818	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	697	233	L	V	Ctt/Gtt	-10.83	0	0	benign	0.17	neutral	0.53	neutral	2.99	neutral	-1.01	neutral	0.22	neutral_impact	0.59	0.96	neutral	0.94	neutral	1.63	14.00	neutral	0.25	0.45	0.26	neutral	0.17	neutral	0.23	neutral	0.27	neutral	5	0.37	neutral	0.68	deleterious	-6	neutral	0.11	neutral	-0.09	medium_impact	0.25	medium_impact	-0.66	medium_impact	0.63	0.8	27.11	30.06	0.39	N	0.06	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15444	15444	T	A	MI.9819	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	698	233	L	H	cTt/cAt	-10.6	0	0	probably_damaging	0.93	neutral	0.22	neutral	2.84	deleterious	-4.38	deleterious	-2.87	high_impact	4	0.93	neutral	0.45	neutral	4.21	23.90	deleterious	0.07	0.35	0.75	disease	0.58	disease	0.65	disease	0.68	disease	4	0.95	neutral	0.15	neutral	2	deleterious	0.68	deleterious	-1.78	low_impact	-0.08	medium_impact	2.44	high_impact	0.17	0.8	27.11	30.06	0.46	N	0.57	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8986	8986	A	G	MI.982	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	460	154	M	V	Ata/Gta	-10.28	0	0	benign	0	neutral	0.22	neutral	4.5	neutral	2.22	neutral	-0.79	neutral_impact	0.03	0.96	neutral	0.98	neutral	-0.44	0.30	neutral	0.48	0.65	0.29	neutral	0.42	neutral	0.45	neutral	0.45	neutral	1	0.78	neutral	0.61	deleterious	-6	neutral	0.15	neutral	2.09	high_impact	-0.02	medium_impact	-1.07	low_impact	0.75	0.9	15.49	11.76	0.37	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15444	15444	T	C	MI.9820	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	698	233	L	P	cTt/cCt	-10.6	0	0	probably_damaging	0.94	neutral	0.08	neutral	2.84	deleterious	-4.07	deleterious	-2.64	medium_impact	3.45	0.93	neutral	0.33	neutral	3.93	23.50	deleterious	0.03	0.35	0.76	disease	0.8	disease	0.7	disease	0.73	disease	5	0.98	deleterious	0.07	neutral	1	deleterious	0.78	deleterious	-1.85	low_impact	-0.35	medium_impact	1.94	medium_impact	0.31	0.8	27.11	30.06	0.39	N	0.79	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15444	15444	T	G	MI.9821	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	698	233	L	R	cTt/cGt	-10.6	0	0	possibly_damaging	0.78	neutral	0.14	neutral	2.85	deleterious	-3.83	deleterious	-2.53	high_impact	4	0.94	neutral	0.42	neutral	4.21	23.90	deleterious	0.03	0.35	0.68	disease	0.79	disease	0.69	disease	0.72	disease	4	0.91	neutral	0.18	neutral	1	deleterious	0.65	deleterious	-1.24	low_impact	-0.21	medium_impact	2.44	high_impact	0.21	0.8	27.11	30.06	0.44	N	0.62	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15446	15446	C	G	MI.9822	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	700	234	L	V	Ctc/Gtc	-11.75	0	0	probably_damaging	0.98	neutral	0.71	neutral	3.15	neutral	-0.26	neutral	-0.48	neutral_impact	0.47	0.93	neutral	0.82	neutral	0.41	6.71	deleterious	0.25	0.45	0.28	neutral	0.15	neutral	0.22	neutral	0.28	neutral	4	0.97	neutral	0.37	neutral	-2	neutral	0.61	deleterious	-2.31	low_impact	0.43	medium_impact	-0.77	medium_impact	0.63	0.8	20	21.38	0.35	N	0.36	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15446	15446	C	T	MI.9823	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	700	234	L	F	Ctc/Ttc	-11.75	0	0	probably_damaging	1	neutral	0.78	neutral	3	neutral	-1.91	neutral	-1.7	low_impact	1.46	0.94	neutral	0.92	neutral	2.47	19.25	deleterious	0.19	0.45	0.3	neutral	0.3	neutral	0.28	neutral	0.45	neutral	1	1	deleterious	0.39	neutral	-2	neutral	0.63	deleterious	-3.53	low_impact	0.52	medium_impact	0.13	medium_impact	0.45	0.8	20	21.38	0.26	N	0.19	polymorphism	1	0.04	rs1057518823	Uncertain_significance	Ischemic_stroke|Focal_white_matter_lesions	361109	Human_Phenotype_Ontology:HP:0002140,MedGen:C0948008,OMIM:601367,SNOMED_CT:422504002|Human_Phenotype_Ontology:HP:0007042,MedGen:C4024946	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15446	15446	C	A	MI.9824	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	700	234	L	I	Ctc/Atc	-11.75	0	0	probably_damaging	0.99	neutral	0.87	neutral	3.18	neutral	0.05	neutral	-0.08	neutral_impact	-0.33	0.91	neutral	0.96	neutral	1.56	13.65	neutral	0.27	0.45	0.21	neutral	0.07	neutral	0.15	neutral	0.22	neutral	6	0.99	deleterious	0.44	neutral	-2	neutral	0.59	deleterious	-2.59	low_impact	0.67	medium_impact	-1.49	low_impact	0.40	0.8	20	21.38	0.42	N	0.08	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15447	15447	T	G	MI.9825	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	701	234	L	R	cTc/cGc	-8.08	0	0	probably_damaging	1	neutral	0.07	neutral	2.96	deleterious	-3.5	deleterious	-3.56	high_impact	4.21	0.84	neutral	0.48	neutral	4.13	23.80	deleterious	0.02	0.35	0.62	disease	0.8	disease	0.68	disease	0.73	disease	5	1	deleterious	0.04	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.39	medium_impact	2.63	high_impact	0.25	0.8	20	21.38	0.41	N	0.89	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15447	15447	T	C	MI.9826	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	701	234	L	P	cTc/cCc	-8.08	0	0	probably_damaging	1	deleterious	0.04	neutral	2.95	deleterious	-4.09	deleterious	-3.88	high_impact	4.21	0.78	neutral	0.37	neutral	3.85	23.40	deleterious	0.02	0.35	0.52	disease	0.8	disease	0.67	disease	0.73	disease	5	1	deleterious	0.02	neutral	6	deleterious	0.79	deleterious	-3.53	low_impact	-0.53	medium_impact	2.63	high_impact	0.28	0.8	20	21.38	0.36	N	0.93	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15447	15447	T	A	MI.9827	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	701	234	L	H	cTc/cAc	-8.08	0	0	probably_damaging	1	neutral	0.12	neutral	2.95	deleterious	-4.05	deleterious	-3.89	high_impact	4.21	0.82	neutral	0.49	neutral	4.08	23.70	deleterious	0.05	0.35	0.4	neutral	0.6	disease	0.63	disease	0.7	disease	4	1	deleterious	0.06	neutral	2	deleterious	0.69	deleterious	-3.53	low_impact	-0.25	medium_impact	2.63	high_impact	0.24	0.8	20	21.38	0.44	N	0.76	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15449	15449	T	C	MI.9828	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	703	235	F	L	Ttc/Ctc	-10.15	0	0	benign	0	neutral	1	neutral	3.24	neutral	-1.43	neutral	1.51	neutral_impact	-0.88	0.99	neutral	0.96	neutral	-0.25	0.87	neutral	0.12	0.4	0.21	neutral	0.16	neutral	0.25	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	1.85	high_impact	-1.99	low_impact	0.22	0.8	16.32	18.6	0.36	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15449	15449	T	A	MI.9829	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	703	235	F	I	Ttc/Atc	-10.15	0	0	benign	0.08	neutral	0.61	neutral	3.14	neutral	-1.64	neutral	0.7	low_impact	1.05	0.95	neutral	0.72	neutral	3.11	22.50	deleterious	0.15	0.45	0.27	neutral	0.38	neutral	0.35	neutral	0.44	neutral	1	0.31	neutral	0.77	deleterious	-6	neutral	0.11	neutral	0.26	medium_impact	0.33	medium_impact	-0.24	medium_impact	0.35	0.8	16.32	18.6	0.33	N	0.26	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8987	8987	T	C	MI.983	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	461	154	M	T	aTa/aCa	-5.89	0	0	benign	0.07	deleterious	0.01	neutral	4.43	neutral	-0.1	deleterious	-3.02	medium_impact	2.11	0.92	neutral	0.7	neutral	1.20	11.76	neutral	0.41	0.65	0.47	neutral	0.48	neutral	0.62	disease	0.58	disease	2	0.99	deleterious	0.47	deleterious	1	deleterious	0.24	neutral	0.31	medium_impact	-0.84	medium_impact	0.71	medium_impact	0.43	0.9	15.49	11.76	0.4	N	0.58	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15449	15449	T	G	MI.9830	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	703	235	F	V	Ttc/Gtc	-10.15	0	0	benign	0.12	neutral	0.35	neutral	3.22	neutral	-1.56	neutral	0.41	low_impact	1.2	0.98	neutral	0.81	neutral	3.76	23.40	deleterious	0.13	0.4	0.25	neutral	0.43	neutral	0.36	neutral	0.43	neutral	1	0.59	neutral	0.62	deleterious	-6	neutral	0.13	neutral	0.08	medium_impact	0.08	medium_impact	-0.1	medium_impact	0.21	0.8	16.32	18.6	0.43	N	0.36	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15450	15450	T	G	MI.9831	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	704	235	F	C	tTc/tGc	-3.27	0	0	possibly_damaging	0.84	neutral	0.08	neutral	3.02	deleterious	-4.68	neutral	-1.19	medium_impact	3.04	0.94	neutral	0.45	neutral	4.10	23.70	deleterious	0.08	0.35	0.66	disease	0.58	disease	0.5	neutral	0.47	neutral	1	0.96	neutral	0.12	neutral	0	NA	0.63	deleterious	-1.4	low_impact	-0.35	medium_impact	1.57	medium_impact	0.17	0.8	16.32	18.6	0.45	N	0.56	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15450	15450	T	A	MI.9832	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	704	235	F	Y	tTc/tAc	-3.27	0	0	benign	0.37	neutral	0.22	neutral	3.04	neutral	-2.77	neutral	-0.88	medium_impact	2.58	0.95	neutral	0.63	neutral	2.74	21.00	deleterious	0.15	0.4	0.4	neutral	0.33	neutral	0.57	disease	0.49	neutral	0	0.74	neutral	0.43	neutral	-3	neutral	0.29	neutral	-0.52	medium_impact	-0.08	medium_impact	1.15	medium_impact	0.41	0.8	16.32	18.6	0.44	N	0.35	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15450	15450	T	C	MI.9833	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	704	235	F	S	tTc/tCc	-3.27	0	0	benign	0.37	neutral	0.09	neutral	3.06	deleterious	-3.33	neutral	-1.41	medium_impact	2.53	0.93	neutral	0.53	neutral	4.06	23.70	deleterious	0.08	0.35	0.29	neutral	0.44	neutral	0.57	disease	0.5	neutral	0	0.9	neutral	0.36	neutral	-3	neutral	0.35	neutral	-0.52	medium_impact	-0.32	medium_impact	1.1	medium_impact	0.34	0.8	16.32	18.6	0.44	N	0.59	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15451	15451	C	A	MI.9834	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	705	235	F	L	ttC/ttA	1.77	0.01	0	benign	0	neutral	1	neutral	3.24	neutral	-1.43	neutral	1.51	neutral_impact	-0.88	0.99	neutral	0.96	neutral	0.45	7.05	deleterious	0.12	0.4	0.21	neutral	0.16	neutral	0.25	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	1.85	high_impact	-1.99	low_impact	0.22	0.8	16.32	18.6	0.34	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15451	15451	C	G	MI.9835	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	705	235	F	L	ttC/ttG	1.77	0.01	0	benign	0	neutral	1	neutral	3.24	neutral	-1.43	neutral	1.51	neutral_impact	-0.88	0.99	neutral	0.96	neutral	0.12	3.86	deleterious	0.12	0.4	0.21	neutral	0.16	neutral	0.25	neutral	0.26	neutral	5	0	neutral	1	deleterious	-6	neutral	0.09	neutral	2.07	high_impact	1.85	high_impact	-1.99	low_impact	0.22	0.8	16.32	18.6	0.31	N	0.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15452	15452	C	A	MI.9836	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	706	236	L	I	Ctt/Att	-0.75	0	0.39	benign	0.22	neutral	0.54	neutral	3.15	neutral	-1.51	neutral	-0.79	neutral_impact	0.68	0.96	neutral	0.95	neutral	0.64	8.43	deleterious	0.24	0.45	0.36	neutral	0.17	neutral	0.25	neutral	0.28	neutral	4	0.35	neutral	0.66	deleterious	-6	neutral	0.15	neutral	-0.22	medium_impact	0.26	medium_impact	-0.58	medium_impact	0.38	0.8	16.84	18.89	0.36	N	0.11	polymorphism	1	0.03	rs193302994,rs527236209	Likely_pathogenic	Neoplasm_of_ovary	153648	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	5.05	.	.	.	.	.	.	P	.	P	neutral
chrM	15452	15452	C	G	MI.9837	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	706	236	L	V	Ctt/Gtt	-0.75	0	0.39	benign	0.09	neutral	0.4	neutral	3.11	neutral	-1.31	neutral	-1.43	medium_impact	2.56	0.91	neutral	0.75	neutral	1.59	13.78	neutral	0.22	0.45	0.36	neutral	0.36	neutral	0.33	neutral	0.46	neutral	1	0.54	neutral	0.66	deleterious	-3	neutral	0.14	neutral	0.21	medium_impact	0.13	medium_impact	1.13	medium_impact	0.51	0.8	16.84	18.89	0.41	N	0.38	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15452	15452	C	T	MI.9838	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	706	236	L	F	Ctt/Ttt	-0.75	0	0.39	benign	0.01	neutral	1	neutral	3.01	neutral	-1.91	neutral	-2.24	low_impact	1.29	0.9	neutral	0.95	neutral	2.44	19.11	deleterious	0.21	0.45	0.57	disease	0.38	neutral	0.31	neutral	0.59	disease	2	0.01	neutral	1	deleterious	-6	neutral	0.13	neutral	1.13	medium_impact	1.85	high_impact	-0.02	medium_impact	0.43	0.8	16.84	18.89	0.26	N	0.21	polymorphism	1	0.11	rs193302994	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	15453	15453	T	C	MI.9839	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	707	236	L	P	cTt/cCt	-2.12	0	0	probably_damaging	0.94	neutral	0.14	neutral	2.89	deleterious	-4.84	deleterious	-4.66	high_impact	4.46	0.83	neutral	0.38	neutral	3.81	23.40	deleterious	0.03	0.35	0.82	disease	0.8	disease	0.7	disease	0.73	disease	5	0.97	neutral	0.1	neutral	2	deleterious	0.81	deleterious	-1.85	low_impact	-0.21	medium_impact	2.86	high_impact	0.29	0.8	16.84	18.89	0.52	P	0.95	polymorphism	1	0.36	rs527236184	Likely_pathogenic	Neoplasm_of_ovary	153614	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	.	T15453C	Isolated complex III deficiency	+	-	Reported	1	P	P	P	damaging
chrM	8987	8987	T	A	MI.984	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	461	154	M	K	aTa/aAa	-5.89	0	0	benign	0.13	deleterious	0.01	neutral	4.37	neutral	-1.68	deleterious	-3.95	medium_impact	2.11	0.84	neutral	0.4	neutral	2.52	19.57	deleterious	0.27	0.65	0.73	disease	0.74	disease	0.69	disease	0.75	disease	5	0.99	deleterious	0.44	neutral	1	deleterious	0.37	neutral	0.03	medium_impact	-0.84	medium_impact	0.71	medium_impact	0.57	0.9	15.49	11.76	0.29	N	0.78	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15453	15453	T	A	MI.9840	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	707	236	L	H	cTt/cAt	-2.12	0	0	probably_damaging	0.91	neutral	0.25	neutral	2.9	deleterious	-4.79	deleterious	-4.6	high_impact	4.81	0.82	neutral	0.49	neutral	4.08	23.70	deleterious	0.05	0.35	0.82	disease	0.73	disease	0.66	disease	0.71	disease	4	0.93	neutral	0.17	neutral	2	deleterious	0.74	deleterious	-1.67	low_impact	-0.04	medium_impact	3.17	high_impact	0.24	0.8	16.84	18.89	0.65	P	0.77	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15453	15453	T	G	MI.9841	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	707	236	L	R	cTt/cGt	-2.12	0	0	possibly_damaging	0.82	neutral	0.16	neutral	2.9	deleterious	-4.24	deleterious	-4.08	high_impact	4.81	0.84	neutral	0.49	neutral	4.04	23.70	deleterious	0.03	0.35	0.76	disease	0.85	disease	0.69	disease	0.72	disease	4	0.91	neutral	0.17	neutral	1	deleterious	0.76	deleterious	-1.35	low_impact	-0.17	medium_impact	3.17	high_impact	0.24	0.8	16.84	18.89	0.67	P	0.89	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15455	15455	C	G	MI.9842	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	709	237	L	V	Ctc/Gtc	-10.83	0	0	benign	0.32	neutral	0.34	neutral	3.14	neutral	-0.92	neutral	-0.62	low_impact	1.63	0.91	neutral	0.72	neutral	1.94	15.84	deleterious	0.3	0.45	0.34	neutral	0.19	neutral	0.28	neutral	0.38	neutral	2	0.59	neutral	0.51	deleterious	-6	neutral	0.18	neutral	-0.43	medium_impact	0.07	medium_impact	0.29	medium_impact	0.37	0.8	21.58	16.91	0.46	N	0.60	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15455	15455	C	T	MI.9843	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	709	237	L	F	Ctc/Ttc	-10.83	0	0	benign	0.06	neutral	0.59	neutral	3.09	neutral	-1.47	neutral	-1.45	neutral_impact	0.62	0.9	neutral	0.87	neutral	2.66	20.50	deleterious	0.24	0.45	0.52	disease	0.24	neutral	0.26	neutral	0.36	neutral	3	0.34	neutral	0.77	deleterious	-6	neutral	0.13	neutral	0.38	medium_impact	0.31	medium_impact	-0.63	medium_impact	0.41	0.8	21.58	16.91	0.34	N	0.31	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15455	15455	C	A	MI.9844	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	709	237	L	I	Ctc/Atc	-10.83	0	0	possibly_damaging	0.56	neutral	0.57	neutral	3.25	neutral	-0.35	neutral	-0.33	low_impact	0.88	0.89	neutral	0.91	neutral	2.57	19.93	deleterious	0.28	0.45	0.26	neutral	0.16	neutral	0.23	neutral	0.29	neutral	4	0.51	neutral	0.51	deleterious	-3	neutral	0.21	neutral	-0.83	medium_impact	0.29	medium_impact	-0.39	medium_impact	0.35	0.8	21.58	16.91	0.41	N	0.50	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15456	15456	T	G	MI.9845	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	710	237	L	R	cTc/cGc	-5.79	0	0.01	probably_damaging	0.95	neutral	0.05	neutral	3.01	deleterious	-3.8	deleterious	-2.81	high_impact	3.66	0.82	neutral	0.51	neutral	4.11	23.70	deleterious	0.04	0.35	0.72	disease	0.74	disease	0.58	disease	0.67	disease	3	0.99	deleterious	0.05	neutral	2	deleterious	0.77	deleterious	-1.92	low_impact	-0.47	medium_impact	2.13	high_impact	0.23	0.8	21.58	16.91	0.37	N	0.99	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15456	15456	T	C	MI.9846	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	710	237	L	P	cTc/cCc	-5.79	0	0.01	probably_damaging	0.99	neutral	0.09	neutral	3	deleterious	-4.04	deleterious	-3.21	medium_impact	3.17	0.91	neutral	0.38	neutral	3.82	23.40	deleterious	0.03	0.35	0.79	disease	0.74	disease	0.66	disease	0.72	disease	4	0.99	deleterious	0.05	neutral	1	deleterious	0.80	deleterious	-2.59	low_impact	-0.32	medium_impact	1.69	medium_impact	0.24	0.8	21.58	16.91	0.39	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15456	15456	T	A	MI.9847	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	710	237	L	H	cTc/cAc	-5.79	0	0.01	probably_damaging	0.98	neutral	0.08	neutral	3	deleterious	-4.37	deleterious	-3.25	high_impact	4.21	0.82	neutral	0.48	neutral	4.06	23.70	deleterious	0.07	0.35	0.78	disease	0.57	disease	0.53	disease	0.58	disease	2	0.99	deleterious	0.05	neutral	2	deleterious	0.73	deleterious	-2.31	low_impact	-0.35	medium_impact	2.63	high_impact	0.13	0.8	21.58	16.91	0.45	N	0.91	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15458	15458	T	G	MI.9848	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	712	238	S	A	Tcc/Gcc	-8.31	0	0	benign	0	neutral	0.6	neutral	3.25	neutral	1.51	neutral	0.86	neutral_impact	-1.09	0.98	neutral	0.97	neutral	-0.47	0.26	neutral	0.26	0.45	0.15	neutral	0.04	neutral	0.23	neutral	0.22	neutral	6	0.39	neutral	0.8	deleterious	-6	neutral	0.06	neutral	2.07	high_impact	0.32	medium_impact	-2.18	low_impact	0.39	0.8	4.74	11.93	0.41	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15458	15458	T	A	MI.9849	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	712	238	S	T	Tcc/Acc	-8.31	0	0	benign	0	neutral	0.29	neutral	3.2	neutral	0.8	neutral	0.21	neutral_impact	-0.42	0.98	neutral	0.97	neutral	0.21	4.77	deleterious	0.27	0.45	0.26	neutral	0.07	neutral	0.23	neutral	0.23	neutral	5	0.71	neutral	0.65	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	0.01	medium_impact	-1.58	low_impact	0.40	0.8	4.74	11.93	0.54	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8988	8988	A	T	MI.985	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	462	154	M	I	atA/atT	5.68	0.89	0	benign	0.02	neutral	0.55	neutral	4.57	neutral	1.84	neutral	-0.48	neutral_impact	-1	0.91	neutral	0.96	neutral	0.33	6.01	deleterious	0.42	0.65	0.28	neutral	0.28	neutral	0.4	neutral	0.42	neutral	2	0.42	neutral	0.77	deleterious	-6	neutral	0.15	neutral	0.85	medium_impact	0.34	medium_impact	-1.95	low_impact	0.82	0.9	15.49	11.76	0.46	N	0.06	polymorphism	0.95	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15458	15458	T	C	MI.9850	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	712	238	S	P	Tcc/Ccc	-8.31	0	0	benign	0.29	neutral	0.23	neutral	3.14	neutral	-1.53	neutral	-1.07	low_impact	1.38	0.97	neutral	0.72	neutral	2.32	18.31	deleterious	0.08	0.35	0.38	neutral	0.6	disease	0.4	neutral	0.24	neutral	5	0.72	neutral	0.47	deleterious	-6	neutral	0.22	neutral	-0.37	medium_impact	-0.06	medium_impact	0.06	medium_impact	0.31	0.8	4.74	11.93	0.57	P	0.22	polymorphism	1	0.03	rs527236185	Likely_pathogenic	Familial_cancer_of_breast	153615	MedGen:C0346153,OMIM:114480,Orphanet:ORPHA227535,SNOMED_CT:254843006	.	.	.	.	.	.	.	.	.	.	P	.	P	neutral
chrM	15459	15459	C	T	MI.9851	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	713	238	S	F	tCc/tTc	-9.69	0	0	benign	0.17	neutral	0.6	neutral	3.19	neutral	0.62	neutral	-0.62	neutral_impact	-0.34	0.97	neutral	0.94	neutral	1.76	14.77	neutral	0.08	0.35	0.23	neutral	0.35	neutral	0.29	neutral	0.44	neutral	1	0.29	neutral	0.72	deleterious	-6	neutral	0.12	neutral	-0.09	medium_impact	0.32	medium_impact	-1.5	low_impact	0.30	0.8	4.74	11.93	0.33	N	0.06	polymorphism	1	0.02	rs527236186	Likely_pathogenic	Neoplasm_of_ovary	153616	Gene:6765,Human_Phenotype_Ontology:HP:0100615,MedGen:C0919267,OMIM:167000,SNOMED_CT:123843001	.	.	.	0.3	.	.	.	.	.	.	P	.	P	neutral
chrM	15459	15459	C	G	MI.9852	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	713	238	S	C	tCc/tGc	-9.69	0	0	possibly_damaging	0.68	neutral	0.09	neutral	3.14	neutral	-1.31	neutral	-0.37	neutral_impact	0.76	0.93	neutral	0.76	neutral	2.25	17.81	deleterious	0.1	0.4	0.54	disease	0.38	neutral	0.29	neutral	0.55	disease	1	0.92	neutral	0.21	neutral	-3	neutral	0.33	neutral	-1.04	low_impact	-0.32	medium_impact	-0.5	medium_impact	0.32	0.8	4.74	11.93	0.48	N	0.15	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15459	15459	C	A	MI.9853	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	713	238	S	Y	tCc/tAc	-9.69	0	0	possibly_damaging	0.49	neutral	0.61	neutral	3.17	neutral	-0.06	neutral	-0.98	low_impact	1.73	0.95	neutral	0.66	neutral	1.35	12.55	neutral	0.09	0.35	0.41	neutral	0.36	neutral	0.38	neutral	0.45	neutral	1	0.43	neutral	0.56	deleterious	-3	neutral	0.22	neutral	-0.72	medium_impact	0.33	medium_impact	0.38	medium_impact	0.28	0.8	4.74	11.93	0.3	N	0.06	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15461	15461	T	G	MI.9854	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	715	239	L	V	Tta/Gta	-12.21	0	0	probably_damaging	0.99	neutral	0.26	neutral	2.95	neutral	-1.44	neutral	-2.31	high_impact	3.82	0.84	neutral	0.55	neutral	3.19	22.70	deleterious	0.29	0.45	0.4	neutral	0.33	neutral	0.66	disease	0.45	neutral	1	1	deleterious	0.14	neutral	2	deleterious	0.67	deleterious	-2.59	low_impact	-0.02	medium_impact	2.28	high_impact	0.44	0.8	48.95	8.77	0.45	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15461	15461	T	A	MI.9855	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	715	239	L	M	Tta/Ata	-12.21	0	0	probably_damaging	1	neutral	0.3	neutral	2.86	neutral	-2.47	neutral	-1.53	medium_impact	2.94	0.88	neutral	0.61	neutral	3.62	23.20	deleterious	0.24	0.45	0.59	disease	0.36	neutral	0.55	disease	0.55	disease	1	1	deleterious	0.15	neutral	1	deleterious	0.69	deleterious	-3.53	low_impact	0.02	medium_impact	1.48	medium_impact	0.48	0.8	48.95	8.77	0.41	N	0.94	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15462	15462	T	C	MI.9856	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	716	239	L	S	tTa/tCa	0.17	0	0	probably_damaging	1	neutral	0.26	neutral	2.82	deleterious	-3.3	deleterious	-4.63	high_impact	4.91	0.77	neutral	0.51	neutral	3.79	23.40	deleterious	0.05	0.35	0.57	disease	0.5	neutral	0.66	disease	0.64	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.72	deleterious	-3.53	low_impact	-0.02	medium_impact	3.26	high_impact	0.31	0.8	48.95	8.77	0.67	P	0.97	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15462	15462	T	G	MI.9857	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	716	239	L	W	tTa/tGa	0.17	0	0	probably_damaging	1	neutral	0.06	neutral	2.79	deleterious	-5.49	deleterious	-4.63	high_impact	4.91	0.84	neutral	0.43	neutral	3.78	23.40	deleterious	0.05	0.35	0.84	disease	0.53	disease	0.69	disease	0.7	disease	4	1	deleterious	0.03	neutral	2	deleterious	0.74	deleterious	-3.53	low_impact	-0.43	medium_impact	3.26	high_impact	0.22	0.8	48.95	8.77	0.66	P	1.00	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15463	15463	A	C	MI.9858	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	717	239	L	F	ttA/ttC	5.67	0.94	0	probably_damaging	1	neutral	0.41	neutral	2.96	neutral	-1.07	deleterious	-2.98	low_impact	1.56	0.92	neutral	0.71	neutral	2.33	18.37	deleterious	0.19	0.45	0.23	neutral	0.34	neutral	0.43	neutral	0.39	neutral	2	1	deleterious	0.21	neutral	-2	neutral	0.66	deleterious	-3.53	low_impact	0.14	medium_impact	0.22	medium_impact	0.50	0.8	48.95	8.77	0.52	P	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15463	15463	A	T	MI.9859	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	717	239	L	F	ttA/ttT	5.67	0.94	0	probably_damaging	1	neutral	0.41	neutral	2.96	neutral	-1.07	deleterious	-2.98	low_impact	1.56	0.92	neutral	0.71	neutral	2.47	19.30	deleterious	0.19	0.45	0.23	neutral	0.34	neutral	0.43	neutral	0.39	neutral	2	1	deleterious	0.21	neutral	-2	neutral	0.66	deleterious	-3.53	low_impact	0.14	medium_impact	0.22	medium_impact	0.50	0.8	48.95	8.77	0.53	P	0.97	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8988	8988	A	C	MI.986	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	462	154	M	I	atA/atC	5.68	0.89	0	benign	0.02	neutral	0.55	neutral	4.57	neutral	1.84	neutral	-0.48	neutral_impact	-1	0.91	neutral	0.96	neutral	0.17	4.35	deleterious	0.42	0.65	0.28	neutral	0.28	neutral	0.4	neutral	0.42	neutral	2	0.42	neutral	0.77	deleterious	-6	neutral	0.15	neutral	0.85	medium_impact	0.34	medium_impact	-1.95	low_impact	0.82	0.9	15.49	11.76	0.46	N	0.06	polymorphism	0.95	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15464	15464	A	T	MI.9860	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	718	240	M	L	Atg/Ttg	-12.21	0	0	probably_damaging	0.93	neutral	1	neutral	3.24	neutral	0.72	neutral	-0.11	neutral_impact	-0.44	0.98	neutral	0.96	neutral	-1.16	0.01	neutral	0.25	0.45	0.19	neutral	0.18	neutral	0.28	neutral	0.32	neutral	4	0.93	neutral	0.54	deleterious	-2	neutral	0.55	deleterious	-1.78	low_impact	1.85	high_impact	-1.59	low_impact	0.30	0.8	16.32	18.46	0.36	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15464	15464	A	C	MI.9861	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	718	240	M	L	Atg/Ctg	-12.21	0	0	probably_damaging	0.93	neutral	1	neutral	3.24	neutral	0.72	neutral	-0.11	neutral_impact	-0.44	0.98	neutral	0.96	neutral	-1.14	0.01	neutral	0.25	0.45	0.19	neutral	0.18	neutral	0.28	neutral	0.32	neutral	4	0.93	neutral	0.54	deleterious	-2	neutral	0.55	deleterious	-1.78	low_impact	1.85	high_impact	-1.59	low_impact	0.30	0.8	16.32	18.46	0.35	N	0.20	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15464	15464	A	G	MI.9862	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	718	240	M	V	Atg/Gtg	-12.21	0	0	probably_damaging	0.96	neutral	0.4	neutral	3.26	neutral	0.76	neutral	-0.13	neutral_impact	0.76	0.98	neutral	0.57	neutral	-0.11	1.62	neutral	0.23	0.45	0.23	neutral	0.22	neutral	0.36	neutral	0.39	neutral	2	0.96	neutral	0.22	neutral	-2	neutral	0.58	deleterious	-2.02	low_impact	0.13	medium_impact	-0.5	medium_impact	0.27	0.8	16.32	18.46	0.42	N	0.69	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15465	15465	T	A	MI.9863	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	719	240	M	K	aTg/aAg	-3.5	0	0	probably_damaging	0.98	neutral	0.11	neutral	3.08	neutral	-2.28	neutral	-1.89	medium_impact	3.42	0.93	neutral	0.4	neutral	2.38	18.67	deleterious	0.05	0.35	0.49	neutral	0.55	disease	0.61	disease	0.66	disease	3	0.99	deleterious	0.07	neutral	1	deleterious	0.69	deleterious	-2.31	low_impact	-0.27	medium_impact	1.91	medium_impact	0.20	0.8	16.32	18.46	0.43	N	0.87	disease_causing	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15465	15465	T	C	MI.9864	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	719	240	M	T	aTg/aCg	-3.5	0	0	probably_damaging	0.99	neutral	0.35	neutral	3.13	neutral	-0.75	neutral	0.24	neutral_impact	0.42	0.99	neutral	0.97	neutral	-0.38	0.44	neutral	0.13	0.4	0.25	neutral	0.09	neutral	0.35	neutral	0.27	neutral	5	0.99	deleterious	0.18	neutral	-2	neutral	0.62	deleterious	-2.59	low_impact	0.08	medium_impact	-0.81	medium_impact	0.18	0.8	16.32	18.46	0.54	N	0.75	polymorphism	1	0.01	.	.	.	.	.	.	COSM6716255	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15466	15466	G	T	MI.9865	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	720	240	M	I	atG/atT	0.4	0	0	probably_damaging	0.97	neutral	0.42	neutral	3.33	neutral	1.35	neutral	-0.34	neutral_impact	0.38	0.95	neutral	0.65	neutral	0.61	8.25	deleterious	0.24	0.45	0.16	neutral	0.2	neutral	0.29	neutral	0.36	neutral	3	0.97	neutral	0.23	neutral	-2	neutral	0.58	deleterious	-2.14	low_impact	0.15	medium_impact	-0.85	medium_impact	0.27	0.8	16.32	18.46	0.37	N	0.56	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15466	15466	G	C	MI.9866	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	720	240	M	I	atG/atC	0.4	0	0	probably_damaging	0.97	neutral	0.42	neutral	3.33	neutral	1.35	neutral	-0.34	neutral_impact	0.38	0.95	neutral	0.65	neutral	0.45	7.05	deleterious	0.24	0.45	0.16	neutral	0.2	neutral	0.29	neutral	0.36	neutral	3	0.97	neutral	0.23	neutral	-2	neutral	0.58	deleterious	-2.14	low_impact	0.15	medium_impact	-0.85	medium_impact	0.27	0.8	16.32	18.46	0.37	N	0.56	disease_causing	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15467	15467	A	C	MI.9867	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	721	241	T	P	Aca/Cca	-5.79	0	0	benign	0.09	neutral	0.24	neutral	3.1	neutral	-2.42	neutral	-2.16	medium_impact	2.96	0.98	neutral	0.39	neutral	2.05	16.56	deleterious	0.08	0.35	0.65	disease	0.67	disease	0.58	disease	0.67	disease	3	0.73	neutral	0.58	deleterious	-3	neutral	0.25	neutral	0.21	medium_impact	-0.05	medium_impact	1.49	medium_impact	0.46	0.8	16.05	16.67	0.36	N	0.88	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15467	15467	A	T	MI.9868	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	721	241	T	S	Aca/Tca	-5.79	0	0	benign	0	neutral	0.45	neutral	3.15	neutral	-0.47	neutral	0	neutral_impact	-0.1	0.98	neutral	0.97	neutral	-1.03	0.01	neutral	0.35	0.5	0.33	neutral	0.06	neutral	0.24	neutral	0.23	neutral	5	0.55	neutral	0.73	deleterious	-6	neutral	0.07	neutral	2.07	high_impact	0.18	medium_impact	-1.28	low_impact	0.68	0.85	16.05	16.67	0.53	N	0.02	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15467	15467	A	G	MI.9869	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	721	241	T	A	Aca/Gca	-5.79	0	0	benign	0	neutral	0.23	neutral	3.31	neutral	1.46	neutral	-0.64	low_impact	1.15	0.96	neutral	0.8	neutral	0.05	3.09	deleterious	0.19	0.45	0.33	neutral	0.13	neutral	0.27	neutral	0.27	neutral	5	0.77	neutral	0.62	deleterious	-6	neutral	0.08	neutral	2.07	high_impact	-0.06	medium_impact	-0.15	medium_impact	0.40	0.8	16.05	16.67	0.47	N	0.17	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8989	8989	G	A	MI.987	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	463	155	A	T	Gcc/Acc	-2.88	0	0.01	probably_damaging	1	neutral	0.79	neutral	4.21	neutral	1.51	deleterious	-3.22	low_impact	1.27	0.82	neutral	0.47	neutral	4.30	24.00	deleterious	0.36	0.65	0.47	neutral	0.55	disease	0.44	neutral	0.44	neutral	1	1	deleterious	0.4	neutral	-2	neutral	0.74	deleterious	-3.6	low_impact	0.62	medium_impact	-0.01	medium_impact	0.75	0.9	44.25	8.13	0.21	N	0.80	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15468	15468	C	A	MI.9870	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	722	241	T	K	aCa/aAa	-6.48	0	0	benign	0.02	neutral	0.14	neutral	3.11	neutral	-1.78	neutral	-1.66	medium_impact	3.1	0.94	neutral	0.46	neutral	1.68	14.27	neutral	0.08	0.35	0.55	disease	0.53	disease	0.55	disease	0.63	disease	3	0.86	neutral	0.56	deleterious	-3	neutral	0.17	neutral	0.85	medium_impact	-0.21	medium_impact	1.62	medium_impact	0.51	0.8	16.05	16.67	0.37	N	0.74	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15468	15468	C	T	MI.9871	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	722	241	T	M	aCa/aTa	-6.48	0	0	possibly_damaging	0.56	neutral	0.38	neutral	3.18	neutral	0.13	neutral	-0.81	neutral_impact	0.34	0.93	neutral	0.92	neutral	2.70	20.80	deleterious	0.12	0.4	0.44	neutral	0.24	neutral	0.25	neutral	0.46	neutral	1	0.63	neutral	0.41	neutral	-3	neutral	0.48	deleterious	-0.83	medium_impact	0.11	medium_impact	-0.89	medium_impact	0.65	0.8	16.05	16.67	0.44	N	0.71	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15470	15470	T	G	MI.9872	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	724	242	L	V	Tta/Gta	-4.19	0	0	probably_damaging	0.99	neutral	0.44	neutral	2.94	neutral	-0.93	neutral	-2.06	medium_impact	2	0.96	neutral	0.13	damaging	3.03	22.30	deleterious	0.21	0.45	0.37	neutral	0.31	neutral	0.42	neutral	0.41	neutral	2	0.99	deleterious	0.23	neutral	1	deleterious	0.66	deleterious	-2.59	low_impact	0.17	medium_impact	0.62	medium_impact	0.49	0.8	57.37	8.45	0.31	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15470	15470	T	A	MI.9873	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	724	242	L	M	Tta/Ata	-4.19	0	0	probably_damaging	1	neutral	0.3	neutral	2.83	deleterious	-3.24	neutral	-1.43	medium_impact	2.92	0.95	neutral	0.19	damaging	3.58	23.20	deleterious	0.18	0.45	0.47	neutral	0.33	neutral	0.39	neutral	0.4	neutral	2	1	deleterious	0.15	neutral	1	deleterious	0.67	deleterious	-3.53	low_impact	0.02	medium_impact	1.46	medium_impact	0.58	0.8	57.37	8.45	0.4	N	0.94	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15471	15471	T	G	MI.9874	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	725	242	L	W	tTa/tGa	-0.75	0	0	probably_damaging	1	neutral	0.08	neutral	2.78	deleterious	-4.63	deleterious	-4.59	high_impact	4.08	0.95	neutral	0.1	damaging	3.77	23.40	deleterious	0.04	0.35	0.56	disease	0.54	disease	0.69	disease	0.64	disease	3	1	deleterious	0.04	neutral	2	deleterious	0.71	deleterious	-3.53	low_impact	-0.35	medium_impact	2.51	high_impact	0.26	0.8	57.37	8.45	0.44	N	1.00	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15471	15471	T	C	MI.9875	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	725	242	L	S	tTa/tCa	-0.75	0	0	probably_damaging	1	neutral	0.25	neutral	2.83	deleterious	-3.28	deleterious	-4.52	high_impact	4.16	0.93	neutral	0.1	damaging	3.76	23.30	deleterious	0.03	0.35	0.55	disease	0.5	neutral	0.66	disease	0.64	disease	3	1	deleterious	0.13	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	-0.04	medium_impact	2.58	high_impact	0.34	0.8	57.37	8.45	0.44	N	0.97	polymorphism	1	0.18	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15472	15472	A	T	MI.9876	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	726	242	L	F	ttA/ttT	3.61	0.36	0	probably_damaging	1	neutral	0.65	neutral	2.92	neutral	-1.64	deleterious	-2.94	medium_impact	2.01	0.97	neutral	0.43	neutral	3.49	23.10	deleterious	0.13	0.4	0.28	neutral	0.4	neutral	0.44	neutral	0.4	neutral	2	1	deleterious	0.33	neutral	1	deleterious	0.66	deleterious	-3.53	low_impact	0.37	medium_impact	0.63	medium_impact	0.53	0.8	57.37	8.45	0.31	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15472	15472	A	C	MI.9877	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	726	242	L	F	ttA/ttC	3.61	0.36	0	probably_damaging	1	neutral	0.65	neutral	2.92	neutral	-1.64	deleterious	-2.94	medium_impact	2.01	0.97	neutral	0.43	neutral	3.40	23.00	deleterious	0.13	0.4	0.28	neutral	0.4	neutral	0.44	neutral	0.4	neutral	2	1	deleterious	0.33	neutral	1	deleterious	0.66	deleterious	-3.53	low_impact	0.37	medium_impact	0.63	medium_impact	0.53	0.8	57.37	8.45	0.31	N	0.97	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15473	15473	A	T	MI.9878	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	727	243	T	S	Aca/Tca	-0.29	0	0	benign	0.4	neutral	0.43	neutral	3.19	neutral	-0.49	neutral	-0.05	neutral_impact	-0.52	0.84	neutral	0.63	neutral	1.76	14.75	neutral	0.35	0.5	0.22	neutral	0.19	neutral	0.29	neutral	0.34	neutral	3	0.51	neutral	0.52	deleterious	-6	neutral	0.21	neutral	-0.57	medium_impact	0.16	medium_impact	-1.67	low_impact	0.64	0.8	22.89	25.04	0.35	N	0.19	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15473	15473	A	G	MI.9879	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	727	243	T	A	Aca/Gca	-0.29	0	0	benign	0.17	neutral	0.57	neutral	3.35	neutral	0.77	neutral	0.9	neutral_impact	-0.7	0.87	neutral	0.82	neutral	0.98	10.56	neutral	0.23	0.45	0.2	neutral	0.06	neutral	0.28	neutral	0.17	neutral	7	0.32	neutral	0.7	deleterious	-6	neutral	0.10	neutral	-0.09	medium_impact	0.29	medium_impact	-1.83	low_impact	0.27	0.8	22.89	25.04	0.35	N	0.05	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8989	8989	G	T	MI.988	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	463	155	A	S	Gcc/Tcc	-2.88	0	0.01	probably_damaging	0.99	neutral	0.29	neutral	4.34	neutral	1.91	deleterious	-2.51	low_impact	1.34	0.66	neutral	0.51	neutral	3.74	23.30	deleterious	0.34	0.65	0.28	neutral	0.75	disease	0.46	neutral	0.5	neutral	0	0.99	deleterious	0.15	neutral	-2	neutral	0.73	deleterious	-2.65	low_impact	0.07	medium_impact	0.05	medium_impact	0.86	0.9	44.25	8.13	0.35	N	0.95	disease_causing	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15473	15473	A	C	MI.9880	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	727	243	T	P	Aca/Cca	-0.29	0	0	possibly_damaging	0.79	neutral	0.22	neutral	3.06	neutral	-2.24	neutral	-1.78	high_impact	3.52	0.84	neutral	0.45	neutral	3.38	22.90	deleterious	0.06	0.35	0.59	disease	0.76	disease	0.71	disease	0.75	disease	5	0.87	neutral	0.22	neutral	1	deleterious	0.61	deleterious	-1.27	low_impact	-0.08	medium_impact	2	high_impact	0.42	0.8	22.89	25.04	0.32	N	0.80	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15474	15474	C	A	MI.9881	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	728	243	T	K	aCa/aAa	0.17	0	0	possibly_damaging	0.52	neutral	0.2	neutral	3.07	neutral	-1.96	neutral	-1.65	high_impact	3.52	0.84	neutral	0.55	neutral	4.30	24.00	deleterious	0.09	0.35	0.43	neutral	0.64	disease	0.69	disease	0.71	disease	4	0.78	neutral	0.34	neutral	1	deleterious	0.42	neutral	-0.76	medium_impact	-0.1	medium_impact	2	high_impact	0.44	0.8	22.89	25.04	0.38	N	0.77	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15474	15474	C	T	MI.9882	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	728	243	T	M	aCa/aTa	0.17	0	0	possibly_damaging	0.8	neutral	0.2	neutral	3.09	neutral	-0.84	neutral	-1.39	low_impact	1.89	0.83	neutral	0.57	neutral	3.94	23.50	deleterious	0.12	0.4	0.4	neutral	0.47	neutral	0.59	disease	0.53	disease	1	0.88	neutral	0.2	neutral	-3	neutral	0.45	deleterious	-1.29	low_impact	-0.1	medium_impact	0.52	medium_impact	0.55	0.8	22.89	25.04	0.36	N	0.51	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15476	15476	C	G	MI.9883	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	730	244	L	V	Cta/Gta	-6.48	0	0	probably_damaging	0.99	neutral	0.45	neutral	3.03	neutral	-0.86	neutral	-2.26	medium_impact	3.19	0.94	neutral	0.13	damaging	3.18	22.70	deleterious	0.38	0.5	0.34	neutral	0.36	neutral	0.67	disease	0.44	neutral	1	0.99	deleterious	0.23	neutral	1	deleterious	0.66	deleterious	-2.59	low_impact	0.18	medium_impact	1.7	medium_impact	0.46	0.8	56.84	8.68	0.32	N	0.73	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15476	15476	C	A	MI.9884	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	730	244	L	M	Cta/Ata	-6.48	0	0	probably_damaging	1	neutral	0.28	neutral	2.91	neutral	-2.55	neutral	-1.45	medium_impact	2.28	0.96	neutral	0.25	damaging	2.66	20.60	deleterious	0.28	0.45	0.54	disease	0.29	neutral	0.4	neutral	0.41	neutral	2	1	deleterious	0.14	neutral	1	deleterious	0.68	deleterious	-3.53	low_impact	0	medium_impact	0.88	medium_impact	0.49	0.8	56.84	8.68	0.4	N	0.26	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15477	15477	T	A	MI.9885	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	731	244	L	Q	cTa/cAa	-1.21	0	0	probably_damaging	1	neutral	0.2	neutral	2.99	neutral	-2.92	deleterious	-4.57	high_impact	3.94	0.94	neutral	0.07	damaging	4.28	24.00	deleterious	0.04	0.35	0.7	disease	0.65	disease	0.67	disease	0.66	disease	3	1	deleterious	0.1	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	-0.1	medium_impact	2.38	high_impact	0.21	0.8	56.84	8.68	0.4	N	0.93	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15477	15477	T	C	MI.9886	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	731	244	L	P	cTa/cCa	-1.21	0	0	probably_damaging	1	neutral	0.23	neutral	2.9	deleterious	-3.09	deleterious	-5.35	high_impact	4.59	0.94	neutral	0.06	damaging	4.01	23.60	deleterious	0.02	0.35	0.76	disease	0.66	disease	0.78	disease	0.72	disease	4	1	deleterious	0.12	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.06	medium_impact	2.97	high_impact	0.12	0.8	56.84	8.68	0.52	N	0.92	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15477	15477	T	G	MI.9887	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	731	244	L	R	cTa/cGa	-1.21	0	0	probably_damaging	1	neutral	0.24	neutral	2.9	deleterious	-3.67	deleterious	-4.59	high_impact	5.14	0.94	neutral	0.06	damaging	4.18	23.80	deleterious	0.02	0.35	0.68	disease	0.79	disease	0.77	disease	0.73	disease	5	1	deleterious	0.12	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	-0.05	medium_impact	3.47	high_impact	0.19	0.8	56.84	8.68	0.71	P	0.99	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15479	15479	T	G	MI.9888	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	733	245	F	V	Ttc/Gtc	-0.06	0.83	0.01	possibly_damaging	0.61	neutral	0.52	neutral	3.07	neutral	-0.83	deleterious	-4.34	high_impact	3.73	0.95	neutral	0.5	neutral	4.05	23.70	deleterious	0.11	0.4	0.39	neutral	0.69	disease	0.67	disease	0.65	disease	3	0.58	neutral	0.46	neutral	1	deleterious	0.46	deleterious	-0.91	medium_impact	0.24	medium_impact	2.19	high_impact	0.28	0.8	21.58	15.99	0.37	N	0.78	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15479	15479	T	A	MI.9889	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	733	245	F	I	Ttc/Atc	-0.06	0.83	0.01	benign	0.29	neutral	0.43	neutral	3.28	neutral	0.49	deleterious	-3.59	medium_impact	2.64	0.94	neutral	0.48	neutral	4.30	24.00	deleterious	0.19	0.45	0.34	neutral	0.61	disease	0.43	neutral	0.44	neutral	1	0.48	neutral	0.57	deleterious	-3	neutral	0.39	neutral	-0.37	medium_impact	0.16	medium_impact	1.2	medium_impact	0.47	0.8	21.58	15.99	0.34	N	0.65	polymorphism	1	0.09	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8989	8989	G	C	MI.989	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	463	155	A	P	Gcc/Ccc	-2.88	0	0.01	probably_damaging	1	deleterious	0	neutral	3.72	deleterious	-3.85	deleterious	-4.39	high_impact	3.94	0.59	damaging	0.44	neutral	3.86	23.50	deleterious	0.15	0.65	0.92	disease	0.93	disease	0.76	disease	0.86	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.28	high_impact	0.76	0.9	44.25	8.13	0.37	N	0.97	disease_causing_automatic	1	0.30	rs587776444	Pathogenic	Leigh_syndrome	165642	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005	.	.	CPD	0.15	.	.	.	.	.	.	P	.	P	damaging
chrM	15479	15479	T	C	MI.9890	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	733	245	F	L	Ttc/Ctc	-0.06	0.83	0.01	benign	0.02	neutral	0.79	neutral	3.13	neutral	-0.33	deleterious	-3.39	low_impact	1.48	0.96	neutral	0.58	neutral	2.70	20.80	deleterious	0.25	0.45	0.4	neutral	0.5	disease	0.37	neutral	0.39	neutral	2	0.17	neutral	0.89	deleterious	-6	neutral	0.17	neutral	0.85	medium_impact	0.53	medium_impact	0.15	medium_impact	0.66	0.8	21.58	15.99	0.2	N	0.08	polymorphism	1	0.08	rs202008188	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15480	15480	T	G	MI.9891	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	734	245	F	C	tTc/tGc	1.31	0.98	0	probably_damaging	0.98	neutral	0.18	neutral	2.94	deleterious	-3.94	deleterious	-5.28	high_impact	4.3	0.94	neutral	0.41	neutral	4.10	23.70	deleterious	0.06	0.35	0.78	disease	0.72	disease	0.69	disease	0.68	disease	4	0.99	deleterious	0.1	neutral	2	deleterious	0.76	deleterious	-2.31	low_impact	-0.14	medium_impact	2.71	high_impact	0.14	0.8	21.58	15.99	0.52	N	0.78	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15480	15480	T	A	MI.9892	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	734	245	F	Y	tTc/tAc	1.31	0.98	0	benign	0.03	neutral	1	neutral	2.96	neutral	-2.69	neutral	-2.03	medium_impact	2.9	0.97	neutral	0.57	neutral	4.20	23.90	deleterious	0.21	0.45	0.28	neutral	0.51	disease	0.46	neutral	0.42	neutral	2	0.03	neutral	0.99	deleterious	-3	neutral	0.18	neutral	0.68	medium_impact	1.85	high_impact	1.44	medium_impact	0.55	0.8	21.58	15.99	0.41	N	0.71	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15480	15480	T	C	MI.9893	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	734	245	F	S	tTc/tCc	1.31	0.98	0	possibly_damaging	0.83	neutral	0.43	neutral	2.96	neutral	-2.62	deleterious	-5.38	high_impact	3.79	0.96	neutral	0.49	neutral	4.31	24.00	deleterious	0.05	0.35	0.62	disease	0.7	disease	0.66	disease	0.65	disease	3	0.82	neutral	0.3	neutral	1	deleterious	0.71	deleterious	-1.37	low_impact	0.16	medium_impact	2.25	high_impact	0.22	0.8	21.58	15.99	0.5	N	0.91	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15481	15481	C	G	MI.9894	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	735	245	F	L	ttC/ttG	4.52	0.99	0	benign	0.02	neutral	0.79	neutral	3.13	neutral	-0.33	deleterious	-3.39	low_impact	1.48	0.96	neutral	0.58	neutral	3.06	22.40	deleterious	0.25	0.45	0.4	neutral	0.5	disease	0.37	neutral	0.39	neutral	2	0.17	neutral	0.89	deleterious	-6	neutral	0.17	neutral	0.85	medium_impact	0.53	medium_impact	0.15	medium_impact	0.66	0.8	21.58	15.99	0.43	N	0.08	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15481	15481	C	A	MI.9895	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	735	245	F	L	ttC/ttA	4.52	0.99	0	benign	0.02	neutral	0.79	neutral	3.13	neutral	-0.33	deleterious	-3.39	low_impact	1.48	0.96	neutral	0.58	neutral	3.30	22.80	deleterious	0.25	0.45	0.4	neutral	0.5	disease	0.37	neutral	0.39	neutral	2	0.17	neutral	0.89	deleterious	-6	neutral	0.17	neutral	0.85	medium_impact	0.53	medium_impact	0.15	medium_impact	0.66	0.8	21.58	15.99	0.42	N	0.08	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15482	15482	T	C	MI.9896	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	736	246	S	P	Tca/Cca	-3.27	0	0	possibly_damaging	0.48	neutral	0.24	neutral	3.09	neutral	-2.02	deleterious	-2.99	medium_impact	2.95	0.93	neutral	0.34	neutral	2.29	18.10	deleterious	0.09	0.35	0.64	disease	0.77	disease	0.44	neutral	0.56	disease	1	0.73	neutral	0.38	neutral	0	NA	0.56	deleterious	-0.7	medium_impact	-0.05	medium_impact	1.49	medium_impact	0.33	0.8	15.53	19.51	0.37	N	0.90	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15482	15482	T	A	MI.9897	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	736	246	S	T	Tca/Aca	-3.27	0	0	benign	0.06	neutral	0.42	neutral	3.15	neutral	-0.37	neutral	-1.12	neutral_impact	0.68	0.98	neutral	0.93	neutral	0.50	7.46	deleterious	0.24	0.45	0.42	neutral	0.26	neutral	0.29	neutral	0.45	neutral	1	0.54	neutral	0.68	deleterious	-6	neutral	0.14	neutral	0.38	medium_impact	0.15	medium_impact	-0.58	medium_impact	0.50	0.8	15.53	19.51	0.44	N	0.07	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15482	15482	T	G	MI.9898	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	736	246	S	A	Tca/Gca	-3.27	0	0	benign	0	neutral	0.54	neutral	3.17	neutral	-0.03	neutral	-1.4	low_impact	0.92	0.97	neutral	0.89	neutral	0.46	7.10	deleterious	0.29	0.45	0.24	neutral	0.23	neutral	0.44	neutral	0.42	neutral	2	0.45	neutral	0.77	deleterious	-6	neutral	0.10	neutral	2.07	high_impact	0.26	medium_impact	-0.36	medium_impact	0.41	0.8	15.53	19.51	0.31	N	0.06	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15483	15483	C	G	MI.9899	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	737	246	S	W	tCa/tGa	-1.44	0	0	probably_damaging	0.94	neutral	0.19	neutral	3.08	neutral	-2.87	deleterious	-3.83	medium_impact	3.29	0.95	neutral	0.41	neutral	4.27	24.00	deleterious	0.09	0.35	0.86	disease	0.73	disease	0.46	neutral	0.62	disease	2	0.96	neutral	0.13	neutral	1	deleterious	0.74	deleterious	-1.85	low_impact	-0.12	medium_impact	1.79	medium_impact	0.24	0.8	15.53	19.51	0.42	N	0.62	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8570	8570	T	A	MI.99	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	44	15	L	Q	cTa/cAa	-1.49	0	0	probably_damaging	1	neutral	0.05	neutral	4.4	deleterious	-3.7	deleterious	-4.04	medium_impact	3.13	0.81	neutral	0.2	damaging	3.83	23.40	deleterious	0.24	0.65	0.82	disease	0.77	disease	0.66	disease	0.75	disease	5	1	deleterious	0.03	neutral	1	deleterious	0.80	deleterious	-3.6	low_impact	-0.43	medium_impact	1.59	medium_impact	0.67	0.9	11.5	26.27	0.28	N	0.71	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8990	8990	C	G	MI.990	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	464	155	A	G	gCc/gGc	7.53	1	0	probably_damaging	0.99	deleterious	0	neutral	3.73	deleterious	-3.12	deleterious	-3.52	high_impact	3.94	0.6	damaging	0.5	neutral	4.07	23.70	deleterious	0.24	0.65	0.84	disease	0.84	disease	0.64	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.65	low_impact	-1.4	low_impact	2.28	high_impact	0.84	0.9	44.25	8.13	0.52	P	0.86	disease_causing	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15483	15483	C	T	MI.9900	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	737	246	S	L	tCa/tTa	-1.44	0	0	benign	0.42	neutral	0.72	neutral	3.11	neutral	-1.15	deleterious	-2.95	low_impact	1.12	0.96	neutral	0.61	neutral	3.10	22.50	deleterious	0.12	0.4	0.46	neutral	0.62	disease	0.44	neutral	0.46	neutral	1	0.31	neutral	0.65	deleterious	-6	neutral	0.44	deleterious	-0.6	medium_impact	0.44	medium_impact	-0.18	medium_impact	0.42	0.8	15.53	19.51	0.23	N	0.57	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15485	15485	C	G	MI.9901	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	739	247	P	A	Cca/Gca	-10.15	0	0	probably_damaging	1	neutral	0.53	neutral	2.47	deleterious	-3.36	deleterious	-6.31	high_impact	4.86	0.93	neutral	0.51	neutral	2.96	22.10	deleterious	0.14	0.4	0.53	disease	0.57	disease	0.76	disease	0.73	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	0.25	medium_impact	3.22	high_impact	0.74	0.85	55.53	8.65	0.62	P	0.82	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15485	15485	C	A	MI.9902	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	739	247	P	T	Cca/Aca	-10.15	0	0	probably_damaging	1	neutral	0.42	neutral	2.43	deleterious	-4.32	deleterious	-6.31	high_impact	4.39	0.92	neutral	0.43	neutral	3.72	23.30	deleterious	0.12	0.4	0.58	disease	0.72	disease	0.77	disease	0.73	disease	5	1	deleterious	0.21	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	0.15	medium_impact	2.79	high_impact	0.56	0.8	55.53	8.65	0.5	N	0.96	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15485	15485	C	T	MI.9903	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	739	247	P	S	Cca/Tca	-10.15	0	0	probably_damaging	1	neutral	0.44	neutral	2.44	deleterious	-4	deleterious	-6.31	high_impact	4.45	0.93	neutral	0.45	neutral	3.91	23.50	deleterious	0.12	0.4	0.62	disease	0.73	disease	0.75	disease	0.73	disease	5	1	deleterious	0.22	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.17	medium_impact	2.85	high_impact	0.14	0.8	55.53	8.65	0.5	N	0.85	polymorphism	1	0.30	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15486	15486	C	A	MI.9904	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	740	247	P	Q	cCa/cAa	4.29	0.99	0	probably_damaging	1	neutral	0.31	neutral	2.43	deleterious	-4.31	deleterious	-6.31	high_impact	3.75	0.91	neutral	0.37	neutral	4.12	23.80	deleterious	0.1	0.4	0.74	disease	0.8	disease	0.8	disease	0.75	disease	5	1	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-3.53	low_impact	0.03	medium_impact	2.21	high_impact	0.35	0.8	55.53	8.65	0.55	P	0.85	polymorphism	1	0.28	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15486	15486	C	T	MI.9905	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	740	247	P	L	cCa/cTa	4.29	0.99	0	probably_damaging	1	neutral	0.69	neutral	2.42	deleterious	-4.63	deleterious	-7.9	high_impact	4.66	0.93	neutral	0.37	neutral	4.35	24.10	deleterious	0.06	0.35	0.27	neutral	0.81	disease	0.75	disease	0.72	disease	4	1	deleterious	0.35	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	0.41	medium_impact	3.04	high_impact	0.71	0.85	55.53	8.65	0.53	N	1.00	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15486	15486	C	G	MI.9906	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	740	247	P	R	cCa/cGa	4.29	0.99	0	probably_damaging	1	neutral	0.36	neutral	2.42	deleterious	-4.51	deleterious	-7.1	high_impact	5.55	0.93	neutral	0.35	neutral	3.59	23.20	deleterious	0.05	0.35	0.73	disease	0.84	disease	0.86	disease	0.79	disease	6	1	deleterious	0.18	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.09	medium_impact	3.85	high_impact	0.30	0.8	55.53	8.65	0.67	P	0.81	polymorphism	1	0.49	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15488	15488	G	T	MI.9907	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	742	248	D	Y	Gac/Tac	-6.25	0	0	probably_damaging	1	neutral	1	neutral	3.19	neutral	1.07	deleterious	-2.55	neutral_impact	0.2	0.91	neutral	0.44	neutral	3.86	23.50	deleterious	0.09	0.35	0.32	neutral	0.68	disease	0.33	neutral	0.45	neutral	1	1	deleterious	0.5	deleterious	-2	neutral	0.72	deleterious	-3.53	low_impact	1.85	high_impact	-1.01	low_impact	0.03	0.8	18.16	11.5	0.18	N	0.94	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15488	15488	G	C	MI.9908	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	742	248	D	H	Gac/Cac	-6.25	0	0	probably_damaging	1	neutral	0.54	neutral	3.15	neutral	-1.13	neutral	-1.03	low_impact	1.72	0.9	neutral	0.35	neutral	3.66	23.20	deleterious	0.18	0.45	0.54	disease	0.68	disease	0.43	neutral	0.48	neutral	0	1	deleterious	0.27	neutral	-2	neutral	0.75	deleterious	-3.53	low_impact	0.26	medium_impact	0.37	medium_impact	0.31	0.8	18.16	11.5	0.24	N	0.66	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15488	15488	G	A	MI.9909	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	742	248	D	N	Gac/Aac	-6.25	0	0	probably_damaging	1	neutral	0.33	neutral	3.19	neutral	0.84	neutral	1.63	neutral_impact	-1.12	0.85	neutral	0.51	neutral	2.15	17.15	deleterious	0.67	0.7	0.18	neutral	0.12	neutral	0.23	neutral	0.25	neutral	5	1	deleterious	0.17	neutral	-2	neutral	0.64	deleterious	-3.53	low_impact	0.06	medium_impact	-2.21	low_impact	0.65	0.8	18.16	11.5	0.36	N	0.23	polymorphism	1	0.00	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	8990	8990	C	T	MI.991	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	464	155	A	V	gCc/gTc	7.53	1	0	probably_damaging	1	neutral	0.11	neutral	3.81	neutral	-1.09	deleterious	-3.45	medium_impact	3.24	0.51	damaging	0.39	neutral	4.54	24.30	deleterious	0.35	0.65	0.71	disease	0.87	disease	0.64	disease	0.71	disease	4	1	deleterious	0.06	neutral	1	deleterious	0.84	deleterious	-3.6	low_impact	-0.22	medium_impact	1.68	medium_impact	0.61	0.9	44.25	8.13	0.65	P	0.75	disease_causing	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15489	15489	A	G	MI.9910	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	743	248	D	G	gAc/gGc	3.15	0.99	0	probably_damaging	1	neutral	0.33	neutral	3.15	neutral	-1.03	neutral	-1.8	medium_impact	2.81	0.88	neutral	0.47	neutral	3.90	23.50	deleterious	0.15	0.4	0.49	neutral	0.7	disease	0.52	disease	0.57	disease	1	1	deleterious	0.17	neutral	1	deleterious	0.74	deleterious	-3.53	low_impact	0.06	medium_impact	1.36	medium_impact	0.19	0.8	18.16	11.5	0.45	N	0.14	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15489	15489	A	C	MI.9911	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	743	248	D	A	gAc/gCc	3.15	0.99	0	probably_damaging	1	neutral	0.51	neutral	3.26	neutral	0.22	deleterious	-2.73	medium_impact	3.02	0.92	neutral	0.48	neutral	3.44	23.00	deleterious	0.15	0.4	0.28	neutral	0.62	disease	0.48	neutral	0.47	neutral	1	1	deleterious	0.26	neutral	1	deleterious	0.70	deleterious	-3.53	low_impact	0.23	medium_impact	1.55	medium_impact	0.20	0.8	18.16	11.5	0.42	N	0.75	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15489	15489	A	T	MI.9912	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	743	248	D	V	gAc/gTc	3.15	0.99	0	probably_damaging	1	neutral	0.5	neutral	3.26	neutral	0.54	deleterious	-3.35	medium_impact	3.37	0.92	neutral	0.48	neutral	3.68	23.30	deleterious	0.06	0.35	0.47	neutral	0.75	disease	0.48	neutral	0.54	disease	1	1	deleterious	0.25	neutral	1	deleterious	0.74	deleterious	-3.53	low_impact	0.22	medium_impact	1.87	medium_impact	0.07	0.8	18.16	11.5	0.42	N	0.93	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15490	15490	C	A	MI.9913	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	744	248	D	E	gaC/gaA	4.52	0.99	0	probably_damaging	0.99	neutral	0.28	neutral	3.19	neutral	-0.11	neutral	-1.13	medium_impact	2.42	0.9	neutral	0.45	neutral	2.62	20.30	deleterious	0.36	0.5	0.28	neutral	0.65	disease	0.4	neutral	0.47	neutral	1	0.99	deleterious	0.15	neutral	1	deleterious	0.68	deleterious	-2.59	low_impact	0	medium_impact	1	medium_impact	0.50	0.8	18.16	11.5	0.52	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15490	15490	C	G	MI.9914	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	744	248	D	E	gaC/gaG	4.52	0.99	0	probably_damaging	0.99	neutral	0.28	neutral	3.19	neutral	-0.11	neutral	-1.13	medium_impact	2.42	0.9	neutral	0.45	neutral	2.28	18.04	deleterious	0.36	0.5	0.28	neutral	0.65	disease	0.4	neutral	0.47	neutral	1	0.99	deleterious	0.15	neutral	1	deleterious	0.68	deleterious	-2.59	low_impact	0	medium_impact	1	medium_impact	0.50	0.8	18.16	11.5	0.52	N	0.46	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15491	15491	C	G	MI.9915	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	745	249	L	V	Ctc/Gtc	0.63	0.17	0	probably_damaging	0.95	neutral	0.5	neutral	3.14	neutral	-0.67	neutral	-2.06	medium_impact	2.38	0.95	neutral	0.19	damaging	1.62	13.99	neutral	0.27	0.45	0.24	neutral	0.42	neutral	0.52	disease	0.44	neutral	1	0.95	neutral	0.28	neutral	1	deleterious	0.61	deleterious	-1.92	low_impact	0.22	medium_impact	0.97	medium_impact	0.31	0.8	20.79	22	0.32	N	0.43	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15491	15491	C	T	MI.9916	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	745	249	L	F	Ctc/Ttc	0.63	0.17	0	probably_damaging	0.99	neutral	0.71	neutral	3.1	neutral	-1.95	deleterious	-2.66	medium_impact	2.77	0.96	neutral	0.13	damaging	3.66	23.20	deleterious	0.2	0.45	0.57	disease	0.54	disease	0.54	disease	0.52	disease	0	0.99	deleterious	0.36	neutral	1	deleterious	0.71	deleterious	-2.59	low_impact	0.43	medium_impact	1.32	medium_impact	0.42	0.8	20.79	22	0.21	N	0.79	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15491	15491	C	A	MI.9917	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	745	249	L	I	Ctc/Atc	0.63	0.17	0	probably_damaging	0.98	neutral	0.41	neutral	3.12	neutral	-1.26	neutral	-1.34	low_impact	1.57	0.95	neutral	0.74	neutral	2.58	19.96	deleterious	0.29	0.45	0.43	neutral	0.36	neutral	0.33	neutral	0.43	neutral	1	0.98	deleterious	0.22	neutral	-2	neutral	0.63	deleterious	-2.31	low_impact	0.14	medium_impact	0.23	medium_impact	0.46	0.8	20.79	22	0.36	N	0.41	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15492	15492	T	C	MI.9918	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	746	249	L	P	cTc/cCc	-1.67	0	0	probably_damaging	1	neutral	0.25	neutral	3.29	neutral	1.24	deleterious	-5.16	medium_impact	3.4	0.93	neutral	0.08	damaging	3.91	23.50	deleterious	0.02	0.35	0.55	disease	0.76	disease	0.75	disease	0.74	disease	5	1	deleterious	0.13	neutral	1	deleterious	0.80	deleterious	-3.53	low_impact	-0.04	medium_impact	1.89	medium_impact	0.18	0.8	20.79	22	0.37	N	0.93	polymorphism	1	0.08	.	not_provided	not_provided	434775	MedGen:CN517202	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15492	15492	T	A	MI.9919	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	746	249	L	H	cTc/cAc	-1.67	0	0	probably_damaging	1	neutral	0.52	neutral	3.11	neutral	-1.73	deleterious	-5.01	high_impact	4.29	0.92	neutral	0.11	damaging	4.13	23.80	deleterious	0.05	0.35	0.55	disease	0.75	disease	0.65	disease	0.67	disease	3	1	deleterious	0.26	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.24	medium_impact	2.7	high_impact	0.18	0.8	20.79	22	0.34	N	0.88	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8990	8990	C	A	MI.992	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	464	155	A	D	gCc/gAc	7.53	1	0	probably_damaging	1	deleterious	0	neutral	3.73	deleterious	-3.64	deleterious	-5.18	high_impact	3.94	0.61	neutral	0.4	neutral	4.72	24.60	deleterious	0.13	0.65	0.93	disease	0.94	disease	0.74	disease	0.83	disease	7	1	deleterious	0	neutral	6	deleterious	0.89	deleterious	-3.6	low_impact	-1.4	low_impact	2.28	high_impact	0.72	0.9	44.25	8.13	0.54	P	0.99	disease_causing	1	0.31	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15492	15492	T	G	MI.9920	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	746	249	L	R	cTc/cGc	-1.67	0	0	probably_damaging	1	neutral	0.34	neutral	3.15	neutral	-0.38	deleterious	-4.41	high_impact	4.44	0.94	neutral	0.08	damaging	4.11	23.70	deleterious	0.03	0.35	0.65	disease	0.85	disease	0.7	disease	0.73	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.07	medium_impact	2.84	high_impact	0.15	0.8	20.79	22	0.44	N	1.00	polymorphism	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15494	15494	C	G	MI.9921	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	748	250	L	V	Cta/Gta	-11.06	0	0	probably_damaging	0.95	neutral	0.58	neutral	3.03	neutral	-1.52	neutral	-2.32	high_impact	3.79	0.96	neutral	0.11	damaging	1.67	14.24	neutral	0.28	0.45	0.71	disease	0.48	neutral	0.63	disease	0.61	disease	2	0.95	neutral	0.32	neutral	2	deleterious	0.72	deleterious	-1.92	low_impact	0.3	medium_impact	2.25	high_impact	0.42	0.8	55.26	8.47	0.26	N	0.88	polymorphism	1	0.04	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15494	15494	C	A	MI.9922	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	748	250	L	M	Cta/Ata	-11.06	0	0	probably_damaging	1	neutral	0.27	neutral	2.98	neutral	-2.96	neutral	-1.54	high_impact	4.06	0.94	neutral	0.13	damaging	3.54	23.10	deleterious	0.26	0.45	0.72	disease	0.49	neutral	0.58	disease	0.57	disease	1	1	deleterious	0.14	neutral	2	deleterious	0.73	deleterious	-3.53	low_impact	-0.01	medium_impact	2.49	high_impact	0.53	0.8	55.26	8.47	0.38	N	0.94	polymorphism	1	0.05	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15495	15495	T	A	MI.9923	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	749	250	L	Q	cTa/cAa	-1.44	0	0	probably_damaging	1	neutral	0.5	neutral	3.04	deleterious	-3.31	deleterious	-4.66	high_impact	5.38	0.93	neutral	0.07	damaging	3.97	23.60	deleterious	0.03	0.35	0.94	disease	0.76	disease	0.71	disease	0.8	disease	6	1	deleterious	0.25	neutral	2	deleterious	0.84	deleterious	-3.53	low_impact	0.22	medium_impact	3.69	high_impact	0.31	0.8	55.26	8.47	0.67	P	0.99	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15495	15495	T	G	MI.9924	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	749	250	L	R	cTa/cGa	-1.44	0	0	probably_damaging	1	neutral	0.52	neutral	3	deleterious	-3.87	deleterious	-4.66	high_impact	4.49	0.94	neutral	0.06	damaging	4.07	23.70	deleterious	0.02	0.35	0.95	disease	0.84	disease	0.82	disease	0.84	disease	7	1	deleterious	0.26	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.24	medium_impact	2.88	high_impact	0.14	0.8	55.26	8.47	0.52	N	0.99	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15495	15495	T	C	MI.9925	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	749	250	L	P	cTa/cCa	-1.44	0	0	probably_damaging	1	neutral	0.32	neutral	3.01	deleterious	-3.33	deleterious	-5.45	high_impact	4.83	0.93	neutral	0.06	damaging	3.90	23.50	deleterious	0.02	0.35	0.96	disease	0.72	disease	0.71	disease	0.8	disease	6	1	deleterious	0.16	neutral	2	deleterious	0.88	deleterious	-3.53	low_impact	0.05	medium_impact	3.19	high_impact	0.24	0.8	55.26	8.47	0.63	P	0.99	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15497	15497	G	C	MI.9926	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	751	251	G	R	Ggc/Cgc	0.17	0.98	0.08	probably_damaging	0.94	neutral	0.42	neutral	3.09	deleterious	-3.18	deleterious	-5.28	high_impact	4.54	0.79	neutral	0.22	damaging	3.90	23.50	deleterious	0.07	0.35	0.55	disease	0.88	disease	0.76	disease	0.76	disease	5	0.94	neutral	0.24	neutral	2	deleterious	0.77	deleterious	-1.85	low_impact	0.15	medium_impact	2.93	high_impact	0.65	0.8	25.79	37.83	0.53	N	0.84	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15497	15497	G	A	MI.9927	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	751	251	G	S	Ggc/Agc	0.17	0.98	0.08	benign	0.13	neutral	0.51	neutral	3.13	neutral	-2.31	deleterious	-3.62	low_impact	1.64	0.89	neutral	0.56	neutral	4.07	23.70	deleterious	0.18	0.45	0.4	neutral	0.74	disease	0.48	neutral	0.47	neutral	1	0.4	neutral	0.69	deleterious	-6	neutral	0.22	neutral	0.04	medium_impact	0.23	medium_impact	0.3	medium_impact	0.65	0.8	25.79	37.83	0.47	N	0.09	polymorphism	1	0.08	rs199951903	Likely_benign	Obesity|not_provided	24726	MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED_CT:414916001|MedGen:CN517202	.	.	CPD	4.75	G15497A	EXIT / Obesity	+	-	Reported	4	N	P	N,P	neutral
chrM	15497	15497	G	T	MI.9928	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	751	251	G	C	Ggc/Tgc	0.17	0.98	0.08	probably_damaging	0.96	neutral	0.18	neutral	3.05	deleterious	-4.53	deleterious	-6.01	high_impact	4	0.79	neutral	0.21	damaging	4.15	23.80	deleterious	0.06	0.35	0.88	disease	0.88	disease	0.65	disease	0.76	disease	5	0.98	neutral	0.11	neutral	2	deleterious	0.81	deleterious	-2.02	low_impact	-0.14	medium_impact	2.44	high_impact	0.12	0.8	25.79	37.83	0.38	N	0.72	polymorphism	1	0.33	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15498	15498	G	C	MI.9929	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	752	251	G	A	gGc/gCc	4.98	1	0	benign	0.23	neutral	0.62	neutral	3.12	neutral	-1.46	deleterious	-3.83	medium_impact	3.36	0.7	neutral	0.41	neutral	3.03	22.30	deleterious	0.22	0.45	0.48	neutral	0.65	disease	0.62	disease	0.55	disease	1	0.27	neutral	0.7	deleterious	-3	neutral	0.38	neutral	-0.24	medium_impact	0.34	medium_impact	1.86	medium_impact	0.35	0.8	25.79	37.83	0.48	N	0.64	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8992	8992	C	G	MI.993	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	466	156	L	V	Ctg/Gtg	-9.36	0	0	probably_damaging	0.99	deleterious	0	neutral	2.31	deleterious	-5.46	deleterious	-2.58	high_impact	4.63	0.31	damaging	0.48	neutral	3.54	23.10	deleterious	0.3	0.65	0.77	disease	0.64	disease	0.76	disease	0.76	disease	5	1	deleterious	0.01	neutral	6	deleterious	0.82	deleterious	-2.65	low_impact	-1.4	low_impact	2.87	high_impact	0.75	0.9	50	8.71	0.72	P	0.87	disease_causing	0.83	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15498	15498	G	A	MI.9930	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	752	251	G	D	gGc/gAc	4.98	1	0	possibly_damaging	0.75	neutral	0.3	neutral	3.12	deleterious	-3.79	deleterious	-4.57	high_impact	5.09	0.44	damaging	0.3	neutral	3.86	23.50	deleterious	0.06	0.35	0.48	neutral	0.86	disease	0.77	disease	0.73	disease	5	0.8	neutral	0.28	neutral	1	deleterious	0.69	deleterious	-1.18	low_impact	0.02	medium_impact	3.43	high_impact	0.15	0.8	25.79	37.83	0.8	P	0.71	disease_causing_automatic	0	0.19	rs207460003	Pathogenic	Infantile_histiocytoid_cardiomyopathy	24723	MedGen:C1708371,OMIM:500000,Orphanet:ORPHA137675	.	.	.	.	G15498A	HiCM / WPW, DEAF	-	+	Reported	6	P	P	P	damaging
chrM	15498	15498	G	T	MI.9931	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	752	251	G	V	gGc/gTc	4.98	1	0	probably_damaging	0.94	neutral	0.54	neutral	3.14	neutral	-1.73	deleterious	-5.99	medium_impact	3.25	0.79	neutral	0.36	neutral	3.76	23.30	deleterious	0.07	0.35	0.63	disease	0.83	disease	0.73	disease	0.73	disease	5	0.93	neutral	0.3	neutral	1	deleterious	0.76	deleterious	-1.85	low_impact	0.26	medium_impact	1.76	medium_impact	0.10	0.8	25.79	37.83	0.4	N	0.86	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15500	15500	G	T	MI.9932	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	754	252	D	Y	Gac/Tac	-0.52	0.04	0	probably_damaging	1	neutral	1	neutral	3.07	deleterious	-4.49	deleterious	-6.99	high_impact	4.85	0.91	neutral	0.44	neutral	4.01	23.60	deleterious	0.04	0.35	0.79	disease	0.9	disease	0.84	disease	0.8	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.84	deleterious	-3.53	low_impact	1.85	high_impact	3.21	high_impact	0.07	0.8	58.16	8.73	0.63	P	1.00	polymorphism	1	0.27	.	.	.	.	.	.	COSM6716238	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15500	15500	G	C	MI.9933	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	754	252	D	H	Gac/Cac	-0.52	0.04	0	probably_damaging	1	neutral	0.53	neutral	3.09	neutral	-1.86	deleterious	-5.43	medium_impact	2.75	0.9	neutral	0.35	neutral	3.67	23.30	deleterious	0.12	0.4	0.25	neutral	0.85	disease	0.81	disease	0.73	disease	5	1	deleterious	0.27	neutral	1	deleterious	0.75	deleterious	-3.53	low_impact	0.25	medium_impact	1.3	medium_impact	0.23	0.8	58.16	8.73	0.33	N	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15500	15500	G	A	MI.9934	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	754	252	D	N	Gac/Aac	-0.52	0.04	0	probably_damaging	0.99	neutral	0.33	neutral	3.12	neutral	-2.22	deleterious	-3.87	high_impact	4.25	0.8	neutral	0.47	neutral	2.71	20.90	deleterious	0.5	0.6	0.37	neutral	0.83	disease	0.78	disease	0.73	disease	5	0.99	deleterious	0.17	neutral	2	deleterious	0.75	deleterious	-2.59	low_impact	0.06	medium_impact	2.67	high_impact	0.73	0.85	58.16	8.73	0.49	N	0.99	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15501	15501	A	C	MI.9935	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	755	252	D	A	gAc/gCc	4.98	1	0	probably_damaging	1	neutral	0.52	neutral	3.17	neutral	-2.54	deleterious	-6.2	high_impact	4.08	0.91	neutral	0.48	neutral	2.64	20.50	deleterious	0.09	0.35	0.48	neutral	0.8	disease	0.81	disease	0.73	disease	5	0.99	deleterious	0.26	neutral	2	deleterious	0.76	deleterious	-3.53	low_impact	0.24	medium_impact	2.51	high_impact	0.26	0.8	58.16	8.73	0.57	P	0.95	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15501	15501	A	T	MI.9936	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	755	252	D	V	gAc/gTc	4.98	1	0	probably_damaging	1	neutral	0.5	neutral	3.09	deleterious	-4.51	deleterious	-6.99	high_impact	5.4	0.91	neutral	0.48	neutral	4.29	24.00	deleterious	0.04	0.35	0.68	disease	0.88	disease	0.81	disease	0.77	disease	5	1	deleterious	0.25	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.22	medium_impact	3.71	high_impact	0.02	0.8	58.16	8.73	0.72	P	1.00	polymorphism	1	0.41	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15501	15501	A	G	MI.9937	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	755	252	D	G	gAc/gGc	4.98	1	0	probably_damaging	1	neutral	0.37	neutral	3.29	neutral	-1.66	deleterious	-5.43	high_impact	5.05	0.9	neutral	0.47	neutral	4.34	24.00	deleterious	0.09	0.35	0.61	disease	0.82	disease	0.81	disease	0.74	disease	5	1	deleterious	0.19	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.1	medium_impact	3.39	high_impact	0.17	0.8	58.16	8.73	0.73	P	1.00	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15502	15502	C	G	MI.9938	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	756	252	D	E	gaC/gaG	6.81	1	0	probably_damaging	0.96	neutral	0.29	neutral	3.21	neutral	-1.69	deleterious	-3.1	medium_impact	2.94	0.84	neutral	0.45	neutral	2.12	16.99	deleterious	0.33	0.5	0.33	neutral	0.76	disease	0.63	disease	0.66	disease	3	0.96	neutral	0.17	neutral	1	deleterious	0.71	deleterious	-2.02	low_impact	0.01	medium_impact	1.48	medium_impact	0.51	0.8	58.16	8.73	0.52	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15502	15502	C	A	MI.9939	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	756	252	D	E	gaC/gaA	6.81	1	0	probably_damaging	0.96	neutral	0.29	neutral	3.21	neutral	-1.69	deleterious	-3.1	medium_impact	2.94	0.84	neutral	0.45	neutral	2.45	19.11	deleterious	0.33	0.5	0.33	neutral	0.76	disease	0.63	disease	0.66	disease	3	0.96	neutral	0.17	neutral	1	deleterious	0.71	deleterious	-2.02	low_impact	0.01	medium_impact	1.48	medium_impact	0.51	0.8	58.16	8.73	0.52	N	1.00	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8992	8992	C	A	MI.994	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	466	156	L	M	Ctg/Atg	-9.36	0	0	probably_damaging	1	deleterious	0	neutral	2.31	deleterious	-5.52	neutral	-1.72	high_impact	4.63	0.46	damaging	0.62	neutral	3.90	23.50	deleterious	0.24	0.65	0.88	disease	0.64	disease	0.75	disease	0.77	disease	5	1	deleterious	0	neutral	6	deleterious	0.81	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.60	0.9	50	8.71	0.58	P	0.96	disease_causing	0.8	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15503	15503	C	G	MI.9940	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	757	253	P	A	Cca/Gca	0.17	0.98	0	probably_damaging	0.99	neutral	0.83	neutral	2.9	neutral	-1.69	deleterious	-5.89	medium_impact	2.94	0.86	neutral	0.15	damaging	1.49	13.25	neutral	0.16	0.45	0.39	neutral	0.6	disease	0.75	disease	0.65	disease	3	0.99	deleterious	0.42	neutral	1	deleterious	0.70	deleterious	-2.59	low_impact	0.6	medium_impact	1.48	medium_impact	0.75	0.85	57.63	8.78	0.33	N	0.82	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15503	15503	C	A	MI.9941	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	757	253	P	T	Cca/Aca	0.17	0.98	0	probably_damaging	1	neutral	0.6	neutral	2.79	deleterious	-3.1	deleterious	-5.87	high_impact	3.96	0.84	neutral	0.11	damaging	3.69	23.30	deleterious	0.15	0.45	0.43	neutral	0.76	disease	0.75	disease	0.67	disease	3	1	deleterious	0.3	neutral	2	deleterious	0.72	deleterious	-3.53	low_impact	0.32	medium_impact	2.4	high_impact	0.56	0.8	57.63	8.78	0.36	N	0.96	polymorphism	1	0.16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15503	15503	C	T	MI.9942	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	757	253	P	S	Cca/Tca	0.17	0.98	0	probably_damaging	1	neutral	0.82	neutral	2.81	neutral	-2.66	deleterious	-5.85	medium_impact	3.18	0.85	neutral	0.1	damaging	3.72	23.30	deleterious	0.16	0.45	0.36	neutral	0.76	disease	0.75	disease	0.66	disease	3	1	deleterious	0.41	neutral	1	deleterious	0.72	deleterious	-3.53	low_impact	0.58	medium_impact	1.69	medium_impact	0.18	0.8	57.63	8.78	0.32	N	0.85	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15504	15504	C	A	MI.9943	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	758	253	P	Q	cCa/cAa	4.29	1	0	probably_damaging	1	neutral	0.54	neutral	2.83	neutral	-2.24	deleterious	-5.94	high_impact	5.41	0.85	neutral	0.09	damaging	4.16	23.80	deleterious	0.12	0.4	0.58	disease	0.83	disease	0.79	disease	0.75	disease	5	1	deleterious	0.27	neutral	2	deleterious	0.75	deleterious	-3.53	low_impact	0.26	medium_impact	3.72	high_impact	0.43	0.8	57.63	8.78	0.66	P	0.85	polymorphism	1	0.36	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15504	15504	C	T	MI.9944	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	758	253	P	L	cCa/cTa	4.29	1	0	probably_damaging	1	neutral	0.61	neutral	2.78	deleterious	-3.21	deleterious	-7.46	high_impact	4.72	0.87	neutral	0.07	damaging	4.43	24.20	deleterious	0.09	0.4	0.67	disease	0.84	disease	0.75	disease	0.75	disease	5	1	deleterious	0.31	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.33	medium_impact	3.09	high_impact	0.54	0.8	57.63	8.78	0.63	P	1.00	polymorphism	1	0.17	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15504	15504	C	G	MI.9945	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	758	253	P	R	cCa/cGa	4.29	1	0	probably_damaging	1	neutral	0.52	neutral	2.79	deleterious	-3.16	deleterious	-6.7	high_impact	5.07	0.86	neutral	0.08	damaging	3.63	23.20	deleterious	0.06	0.35	0.6	disease	0.86	disease	0.82	disease	0.77	disease	5	1	deleterious	0.26	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.24	medium_impact	3.41	high_impact	0.34	0.8	57.63	8.78	0.68	P	0.81	polymorphism	1	0.34	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15506	15506	G	C	MI.9946	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	760	254	D	H	Gac/Cac	-3.27	0	0	possibly_damaging	0.76	neutral	0.56	neutral	4.49	neutral	-2.99	deleterious	-3.14	high_impact	4.17	0.8	neutral	0.34	neutral	3.58	23.20	deleterious	0.18	0.45	0.65	disease	0.85	disease	0.76	disease	0.77	disease	5	0.73	neutral	0.4	neutral	1	deleterious	0.71	deleterious	-1.2	low_impact	0.28	medium_impact	2.59	high_impact	0.35	0.8	55	8.37	0.33	N	1.00	polymorphism	1	0.35	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15506	15506	G	A	MI.9947	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	760	254	D	N	Gac/Aac	-3.27	0	0	benign	0.12	neutral	0.4	neutral	4.55	neutral	-1.99	neutral	-2.42	medium_impact	2.82	0.64	neutral	0.45	neutral	2.55	19.80	deleterious	0.62	0.65	0.49	neutral	0.83	disease	0.69	disease	0.7	disease	4	0.53	neutral	0.64	deleterious	-3	neutral	0.30	neutral	0.08	medium_impact	0.13	medium_impact	1.37	medium_impact	0.46	0.8	55	8.37	0.28	N	0.99	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15506	15506	G	T	MI.9948	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	760	254	D	Y	Gac/Tac	-3.27	0	0	possibly_damaging	0.84	neutral	1	neutral	4.48	neutral	-1.94	deleterious	-4.64	high_impact	4.38	0.81	neutral	0.44	neutral	3.90	23.50	deleterious	0.07	0.35	0.75	disease	0.9	disease	0.76	disease	0.79	disease	6	0.84	neutral	0.58	deleterious	1	deleterious	0.76	deleterious	-1.4	low_impact	1.85	high_impact	2.78	high_impact	0.12	0.8	55	8.37	0.41	N	1.00	polymorphism	1	0.32	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15507	15507	A	T	MI.9949	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	761	254	D	V	gAc/gTc	4.98	1	0	benign	0.35	neutral	0.52	neutral	4.51	neutral	-1.93	deleterious	-4.67	high_impact	3.62	0.81	neutral	0.48	neutral	3.53	23.10	deleterious	0.06	0.35	0.62	disease	0.87	disease	0.75	disease	0.78	disease	6	0.4	neutral	0.59	deleterious	-2	neutral	0.51	deleterious	-0.48	medium_impact	0.24	medium_impact	2.09	high_impact	0.08	0.8	55	8.37	0.53	N	1.00	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8993	8993	T	G	MI.995	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	467	156	L	R	cTg/cGg	-1.03	0	0.03	probably_damaging	1	deleterious	0	neutral	2.25	deleterious	-8.72	deleterious	-5.18	high_impact	4.63	0.06	damaging	0.42	neutral	4.27	24.00	deleterious	0.1	0.65	0.88	disease	0.88	disease	0.84	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.91	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.48	0.9	50	8.71	0.95	P	0.99	disease_causing_automatic	0.58	0.42	rs199476133	Pathogenic	Scrotal_hypoplasia|Hypertelorism|Low-set_ears|Postaxial_hand_polydactyly|Cerebellar_ataxia|Premature_birth|Bilateral_cleft_lip_and_palate|Wide_intermamillary_distance|Camptodactyly_of_finger|Leigh_syndrome|Mitochondrial_diseases|Neuropathy_ataxia_retinitis_pigmentosa_syndrome|not_provided	24680	Human_Phenotype_Ontology:HP:0000046,MedGen:CN000046|Human_Phenotype_Ontology:HP:0000316,MedGen:C0020534,OMIM:145400|Human_Phenotype_Ontology:HP:0000369,MedGen:C0239234|Human_Phenotype_Ontology:HP:0001162,MedGen:C0431904|Human_Phenotype_Ontology:HP:0001251,MedGen:C0007758,SNOMED_CT:85102008|Human_Phenotype_Ontology:HP:0001622,MedGen:C0233315|Human_Phenotype_Ontology:HP:0002744,MedGen:C1398522|Human_Phenotype_Ontology:HP:0006610,MedGen:C1827524|Human_Phenotype_Ontology:HP:0100490,MedGen:C0409348|MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C0751651,Orphanet:ORPHA68380|MedGen:C1328349,OMIM:551500,Orphanet:ORPHA644|MedGen:CN517202	.	.	.	.	T8993G	NARP / Leigh Disease / MILS / other	-	+	Cfrm	90	P	P	P	damaging
chrM	15507	15507	A	G	MI.9950	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	761	254	D	G	gAc/gGc	4.98	1	0	benign	0.16	neutral	0.35	neutral	4.5	neutral	-2	deleterious	-3.98	high_impact	4.03	0.8	neutral	0.47	neutral	3.61	23.20	deleterious	0.12	0.4	0.42	neutral	0.82	disease	0.74	disease	0.74	disease	5	0.59	neutral	0.6	deleterious	-2	neutral	0.26	neutral	-0.06	medium_impact	0.08	medium_impact	2.47	high_impact	0.26	0.8	55	8.37	0.59	P	1.00	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15507	15507	A	C	MI.9951	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	761	254	D	A	gAc/gCc	4.98	1	0	benign	0.05	neutral	0.54	neutral	4.56	neutral	-1.53	deleterious	-3.89	high_impact	3.68	0.82	neutral	0.47	neutral	2.01	16.25	deleterious	0.14	0.4	0.43	neutral	0.8	disease	0.73	disease	0.72	disease	4	0.41	neutral	0.75	deleterious	-2	neutral	0.26	neutral	0.46	medium_impact	0.26	medium_impact	2.15	high_impact	0.29	0.8	55	8.37	0.54	N	0.95	polymorphism	1	0.12	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15508	15508	C	G	MI.9952	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	762	254	D	E	gaC/gaG	5.67	1	0.06	benign	0.03	neutral	0.33	neutral	4.66	neutral	0.18	neutral	-0.13	neutral_impact	0.34	0.8	neutral	0.44	neutral	0.73	9.02	deleterious	0.32	0.5	0.25	neutral	0.27	neutral	0.41	neutral	0.39	neutral	2	0.65	neutral	0.65	deleterious	-6	neutral	0.13	neutral	0.68	medium_impact	0.06	medium_impact	-0.89	medium_impact	0.43	0.8	55	8.37	0.57	P	1.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15508	15508	C	A	MI.9953	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	762	254	D	E	gaC/gaA	5.67	1	0.06	benign	0.03	neutral	0.33	neutral	4.66	neutral	0.18	neutral	-0.13	neutral_impact	0.34	0.8	neutral	0.44	neutral	1.05	10.92	neutral	0.32	0.5	0.25	neutral	0.27	neutral	0.41	neutral	0.39	neutral	2	0.65	neutral	0.65	deleterious	-6	neutral	0.13	neutral	0.68	medium_impact	0.06	medium_impact	-0.89	medium_impact	0.43	0.8	55	8.37	0.57	P	1.00	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15509	15509	A	T	MI.9954	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	763	255	N	Y	Aat/Tat	-3.04	0	0	possibly_damaging	0.73	neutral	1	neutral	4.26	deleterious	-3.96	deleterious	-6.11	high_impact	4.74	0.83	neutral	0.31	neutral	3.35	22.90	deleterious	0.1	0.4	0.7	disease	0.73	disease	0.84	disease	0.75	disease	5	0.73	neutral	0.64	deleterious	1	deleterious	0.70	deleterious	-1.13	low_impact	1.85	high_impact	3.11	high_impact	0.15	0.8	56.84	8.67	0.6	P	1.00	polymorphism	1	0.48	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15509	15509	A	G	MI.9955	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	763	255	N	D	Aat/Gat	-3.04	0	0	benign	0	neutral	0.34	neutral	4.3	neutral	-2.56	deleterious	-3.82	high_impact	4.39	0.75	neutral	0.36	neutral	1.90	15.61	deleterious	0.55	0.6	0.64	disease	0.6	disease	0.8	disease	0.74	disease	5	0.66	neutral	0.67	deleterious	-2	neutral	0.20	neutral	2.07	high_impact	0.07	medium_impact	2.79	high_impact	0.20	0.8	56.84	8.67	0.5	N	0.95	polymorphism	1	0.43	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15509	15509	A	C	MI.9956	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	763	255	N	H	Aat/Cat	-3.04	0	0	possibly_damaging	0.53	neutral	0.56	neutral	4.27	deleterious	-3.9	deleterious	-3.82	high_impact	4.74	0.82	neutral	0.18	damaging	2.66	20.60	deleterious	0.37	0.5	0.72	disease	0.7	disease	0.84	disease	0.75	disease	5	0.49	neutral	0.52	deleterious	1	deleterious	0.64	deleterious	-0.78	medium_impact	0.28	medium_impact	3.11	high_impact	0.10	0.8	56.84	8.67	0.63	P	0.98	polymorphism	1	0.46	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15510	15510	A	C	MI.9957	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	764	255	N	T	aAt/aCt	6.81	1	0	benign	0.12	neutral	0.51	neutral	4.3	neutral	-2.91	deleterious	-4.57	high_impact	4.6	0.77	neutral	0.39	neutral	1.68	14.28	neutral	0.29	0.45	0.52	disease	0.74	disease	0.82	disease	0.74	disease	5	0.4	neutral	0.7	deleterious	-2	neutral	0.37	neutral	0.08	medium_impact	0.23	medium_impact	2.98	high_impact	0.16	0.8	56.84	8.67	0.64	P	0.94	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15510	15510	A	T	MI.9958	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	764	255	N	I	aAt/aTt	6.81	1	0	possibly_damaging	0.65	neutral	0.43	neutral	4.26	deleterious	-3.48	deleterious	-6.88	high_impact	4.95	0.89	neutral	0.41	neutral	4.00	23.60	deleterious	0.1	0.4	0.38	neutral	0.76	disease	0.81	disease	0.73	disease	5	0.66	neutral	0.39	neutral	1	deleterious	0.61	deleterious	-0.98	medium_impact	0.16	medium_impact	3.3	high_impact	0.15	0.8	56.84	8.67	0.68	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15510	15510	A	G	MI.9959	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	764	255	N	S	aAt/aGt	6.81	1	0	benign	0.02	neutral	0.53	neutral	4.33	neutral	-2.1	deleterious	-3.8	high_impact	4.49	0.83	neutral	0.39	neutral	1.32	12.36	neutral	0.53	0.6	0.5	disease	0.68	disease	0.8	disease	0.71	disease	4	0.45	neutral	0.76	deleterious	-2	neutral	0.25	neutral	0.85	medium_impact	0.25	medium_impact	2.88	high_impact	0.13	0.8	56.84	8.67	0.63	P	0.86	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8993	8993	T	A	MI.996	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	467	156	L	Q	cTg/cAg	-1.03	0	0.03	probably_damaging	1	deleterious	0	neutral	2.25	deleterious	-8.91	deleterious	-5.16	high_impact	4.63	0.36	damaging	0.48	neutral	4.27	24.00	deleterious	0.12	0.65	0.89	disease	0.83	disease	0.76	disease	0.82	disease	6	1	deleterious	0	neutral	6	deleterious	0.87	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.68	0.9	50	8.71	0.7	P	0.98	disease_causing	0.52	0.42	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15511	15511	T	A	MI.9960	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	765	255	N	K	aaT/aaA	5.44	1	0	benign	0.15	neutral	0.44	neutral	4.36	neutral	-2.72	deleterious	-4.59	high_impact	4.74	0.9	neutral	0.28	damaging	2.64	20.40	deleterious	0.38	0.5	0.37	neutral	0.73	disease	0.8	disease	0.72	disease	4	0.48	neutral	0.65	deleterious	-2	neutral	0.49	deleterious	-0.03	medium_impact	0.17	medium_impact	3.11	high_impact	0.22	0.8	56.84	8.67	0.68	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15511	15511	T	G	MI.9961	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	765	255	N	K	aaT/aaG	5.44	1	0	benign	0.15	neutral	0.44	neutral	4.36	neutral	-2.72	deleterious	-4.59	high_impact	4.74	0.9	neutral	0.28	damaging	2.40	18.83	deleterious	0.38	0.5	0.37	neutral	0.73	disease	0.8	disease	0.72	disease	4	0.48	neutral	0.65	deleterious	-2	neutral	0.49	deleterious	-0.03	medium_impact	0.17	medium_impact	3.11	high_impact	0.22	0.8	56.84	8.67	0.67	P	1.00	polymorphism	1	0.38	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15512	15512	T	C	MI.9962	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	766	256	Y	H	Tat/Cat	0.17	0.98	0	probably_damaging	1	neutral	0.54	neutral	4.51	neutral	-2.57	deleterious	-3.24	medium_impact	2.64	0.75	neutral	0.34	neutral	3.37	22.90	deleterious	0.15	0.4	0.72	disease	0.71	disease	0.8	disease	0.77	disease	5	1	deleterious	0.27	neutral	1	deleterious	0.81	deleterious	-3.53	low_impact	0.26	medium_impact	1.2	medium_impact	0.13	0.8	17.37	22.23	0.36	N	0.93	polymorphism	1	0.27	rs879031246	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	damaging
chrM	15512	15512	T	G	MI.9963	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	766	256	Y	D	Tat/Gat	0.17	0.98	0	probably_damaging	1	neutral	0.27	neutral	4.51	deleterious	-3.1	deleterious	-5.36	medium_impact	3.19	0.79	neutral	0.36	neutral	3.74	23.30	deleterious	0.04	0.35	0.79	disease	0.82	disease	0.84	disease	0.82	disease	6	1	deleterious	0.14	neutral	1	deleterious	0.84	deleterious	-3.53	low_impact	-0.01	medium_impact	1.7	medium_impact	0.07	0.8	17.37	22.23	0.38	N	0.97	disease_causing	1	0.22	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15512	15512	T	A	MI.9964	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	766	256	Y	N	Tat/Aat	0.17	0.98	0	probably_damaging	1	neutral	0.41	neutral	4.52	neutral	-2.68	deleterious	-5.16	medium_impact	2.5	0.83	neutral	0.44	neutral	3.98	23.60	deleterious	0.07	0.35	0.71	disease	0.84	disease	0.79	disease	0.78	disease	6	1	deleterious	0.21	neutral	1	deleterious	0.83	deleterious	-3.53	low_impact	0.14	medium_impact	1.08	medium_impact	0.11	0.8	17.37	22.23	0.37	N	0.96	polymorphism	1	0.19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15513	15513	A	T	MI.9965	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	767	256	Y	F	tAt/tTt	5.67	1	0	probably_damaging	0.97	neutral	0.74	neutral	4.81	neutral	1.14	neutral	0.92	neutral_impact	-1.96	0.9	neutral	0.47	neutral	-0.51	0.21	neutral	0.31	0.45	0.27	neutral	0.1	neutral	0.45	neutral	0.22	neutral	6	0.97	neutral	0.39	neutral	-2	neutral	0.65	deleterious	-2.14	low_impact	0.47	medium_impact	-2.97	low_impact	0.47	0.8	17.37	22.23	0.51	N	0.43	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15513	15513	A	G	MI.9966	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	767	256	Y	C	tAt/tGt	5.67	1	0	probably_damaging	1	neutral	0.17	neutral	4.51	deleterious	-3.59	deleterious	-4.61	medium_impact	2.64	0.84	neutral	0.32	neutral	3.53	23.10	deleterious	0.04	0.35	0.74	disease	0.84	disease	0.81	disease	0.78	disease	6	1	deleterious	0.09	neutral	1	deleterious	0.81	deleterious	-3.53	low_impact	-0.15	medium_impact	1.2	medium_impact	0.07	0.8	17.37	22.23	0.49	N	0.96	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15513	15513	A	C	MI.9967	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	767	256	Y	S	tAt/tCt	5.67	1	0	probably_damaging	1	neutral	0.42	neutral	4.57	neutral	-1.79	deleterious	-4.57	medium_impact	1.99	0.88	neutral	0.49	neutral	3.39	23.00	deleterious	0.06	0.35	0.54	disease	0.77	disease	0.78	disease	0.77	disease	5	0.99	deleterious	0.21	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.15	medium_impact	0.61	medium_impact	0.15	0.8	17.37	22.23	0.5	N	0.90	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15515	15515	A	C	MI.9968	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	769	257	T	P	Acc/Ccc	-2.58	0	0	benign	0.32	neutral	0.32	neutral	4.6	neutral	-1.85	deleterious	-3.73	high_impact	3.94	0.84	neutral	0.32	neutral	3.13	22.60	deleterious	0.04	0.35	0.6	disease	0.71	disease	0.54	disease	0.61	disease	2	0.61	neutral	0.5	deleterious	-2	neutral	0.50	deleterious	-0.43	medium_impact	0.05	medium_impact	2.38	high_impact	0.40	0.8	16.84	19.36	0.34	N	0.93	polymorphism	1	0.14	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15515	15515	A	G	MI.9969	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	769	257	T	A	Acc/Gcc	-2.58	0	0	benign	0.02	neutral	0.53	neutral	4.66	neutral	-0.5	deleterious	-2.77	medium_impact	3.05	0.92	neutral	0.59	neutral	1.59	13.78	neutral	0.25	0.45	0.33	neutral	0.4	neutral	0.56	disease	0.43	neutral	1	0.45	neutral	0.76	deleterious	-3	neutral	0.12	neutral	0.85	medium_impact	0.25	medium_impact	1.58	medium_impact	0.36	0.8	16.84	19.36	0.27	N	0.37	polymorphism	1	0.08	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8993	8993	T	C	MI.997	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	467	156	L	P	cTg/cCg	-1.03	0	0.03	probably_damaging	1	deleterious	0	neutral	2.25	deleterious	-8.95	deleterious	-5.96	high_impact	4.63	0.05	damaging	0.51	neutral	3.98	23.60	deleterious	0.12	0.65	0.93	disease	0.83	disease	0.83	disease	0.87	disease	7	1	deleterious	0	neutral	6	deleterious	0.90	deleterious	-3.6	low_impact	-1.4	low_impact	2.87	high_impact	0.43	0.9	50	8.71	0.95	P	1.00	disease_causing_automatic	1	0.43	rs199476133	Pathogenic	Leigh_syndrome|Mitochondrial_diseases|Ataxia_and_polyneuropathy,_adult-onset	24681	MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C0751651,Orphanet:ORPHA68380|MedGen:C1838916,OMIM:500010	.	.	.	.	T8993C	NARP / Leigh Disease / MILS / other	-	+	Cfrm	30	P	P	P	damaging
chrM	15515	15515	A	T	MI.9970	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	769	257	T	S	Acc/Tcc	-2.58	0	0	benign	0	neutral	0.43	neutral	4.66	neutral	-0.35	neutral	-1.99	low_impact	1.39	0.91	neutral	0.88	neutral	0.28	5.47	deleterious	0.3	0.45	0.35	neutral	0.33	neutral	0.36	neutral	0.4	neutral	2	0.57	neutral	0.72	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	0.16	medium_impact	0.07	medium_impact	0.61	0.8	16.84	19.36	0.36	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15516	15516	C	T	MI.9971	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	770	257	T	I	aCc/aTc	4.52	0.24	0	benign	0.01	neutral	0.42	neutral	4.76	neutral	1.07	deleterious	-3.14	neutral_impact	0.08	0.95	neutral	0.97	neutral	2.60	20.20	deleterious	0.13	0.4	0.16	neutral	0.36	neutral	0.31	neutral	0.4	neutral	2	0.57	neutral	0.71	deleterious	-6	neutral	0.10	neutral	1.13	medium_impact	0.15	medium_impact	-1.12	low_impact	0.58	0.8	16.84	19.36	0.33	N	0.16	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15516	15516	C	A	MI.9972	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	770	257	T	N	aCc/aAc	4.52	0.24	0	benign	0.12	neutral	0.35	neutral	4.63	neutral	-1.47	deleterious	-2.82	medium_impact	2.17	0.83	neutral	0.51	neutral	2.13	17.05	deleterious	0.33	0.5	0.42	neutral	0.67	disease	0.39	neutral	0.48	neutral	0	0.59	neutral	0.62	deleterious	-3	neutral	0.23	neutral	0.08	medium_impact	0.08	medium_impact	0.78	medium_impact	0.62	0.8	16.84	19.36	0.35	N	0.66	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15516	15516	C	G	MI.9973	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	770	257	T	S	aCc/aGc	4.52	0.24	0	benign	0	neutral	0.43	neutral	4.66	neutral	-0.35	neutral	-1.99	low_impact	1.39	0.91	neutral	0.88	neutral	0.61	8.24	deleterious	0.3	0.45	0.35	neutral	0.33	neutral	0.36	neutral	0.4	neutral	2	0.57	neutral	0.72	deleterious	-6	neutral	0.13	neutral	2.07	high_impact	0.16	medium_impact	0.07	medium_impact	0.61	0.8	16.84	19.36	0.37	N	0.18	polymorphism	1	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15518	15518	C	A	MI.9974	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	772	258	L	M	Cta/Ata	-3.5	0	0.04	possibly_damaging	0.8	neutral	0.36	neutral	4.68	neutral	-0.72	neutral	0.65	neutral_impact	0.46	0.94	neutral	0.54	neutral	3.81	23.40	deleterious	0.32	0.5	0.24	neutral	0.29	neutral	0.49	neutral	0.38	neutral	2	0.82	neutral	0.28	neutral	-3	neutral	0.54	deleterious	-1.29	low_impact	0.09	medium_impact	-0.78	medium_impact	0.49	0.8	20.26	20.03	0.39	N	0.55	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15518	15518	C	G	MI.9975	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	772	258	L	V	Cta/Gta	-3.5	0	0.04	benign	0.4	neutral	0.68	neutral	4.69	neutral	-0.26	neutral	0.57	neutral_impact	0.46	0.94	neutral	0.75	neutral	3.32	22.90	deleterious	0.3	0.45	0.3	neutral	0.28	neutral	0.6	disease	0.41	neutral	2	0.31	neutral	0.64	deleterious	-6	neutral	0.28	neutral	-0.57	medium_impact	0.4	medium_impact	-0.78	medium_impact	0.43	0.8	20.26	20.03	0.25	N	0.53	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15519	15519	T	C	MI.9976	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	773	258	L	P	cTa/cCa	2.92	0.94	0	possibly_damaging	0.72	neutral	0.73	neutral	4.92	neutral	1.33	neutral	6.67	neutral_impact	0.46	0.97	neutral	0.91	neutral	1.21	11.79	neutral	0.05	0.35	0.21	neutral	0.03	neutral	0.29	neutral	0.17	neutral	7	0.66	neutral	0.51	deleterious	-3	neutral	0.39	neutral	-1.11	low_impact	0.46	medium_impact	-0.78	medium_impact	0.11	0.8	20.26	20.03	0.37	N	0.01	polymorphism	1	0.01	rs200913192	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	.	N	neutral
chrM	15519	15519	T	A	MI.9977	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	773	258	L	Q	cTa/cAa	2.92	0.94	0	benign	0.02	neutral	0.63	neutral	4.68	neutral	-1.23	neutral	1.25	neutral_impact	0.46	0.97	neutral	0.85	neutral	4.06	23.70	deleterious	0.09	0.35	0.22	neutral	0.48	neutral	0.4	neutral	0.44	neutral	1	0.34	neutral	0.81	deleterious	-6	neutral	0.15	neutral	0.85	medium_impact	0.35	medium_impact	-0.78	medium_impact	0.14	0.8	20.26	20.03	0.31	N	0.54	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15519	15519	T	G	MI.9978	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	773	258	L	R	cTa/cGa	2.92	0.94	0	benign	0.25	neutral	0.55	neutral	4.66	neutral	-1.56	neutral	0.49	low_impact	0.8	0.97	neutral	0.54	neutral	4.21	23.90	deleterious	0.05	0.35	0.34	neutral	0.77	disease	0.69	disease	0.69	disease	4	0.34	neutral	0.65	deleterious	-6	neutral	0.34	neutral	-0.29	medium_impact	0.27	medium_impact	-0.47	medium_impact	0.15	0.8	20.26	20.03	0.29	N	0.66	polymorphism	1	0.01	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15521	15521	G	A	MI.9979	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	775	259	A	T	Gcc/Acc	-4.42	0	0	probably_damaging	1	neutral	0.49	neutral	2.49	deleterious	-5.18	deleterious	-3.01	high_impact	5.25	0.92	neutral	0.44	neutral	4.05	23.70	deleterious	0.1	0.4	0.59	disease	0.81	disease	0.72	disease	0.72	disease	4	1	deleterious	0.25	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.21	medium_impact	3.57	high_impact	0.78	0.85	58.42	8.68	0.72	P	0.79	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8995	8995	G	T	MI.998	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	469	157	A	S	Gcc/Tcc	-1.26	0	0	probably_damaging	0.99	neutral	0.39	neutral	3.91	neutral	0	neutral	-1.72	neutral_impact	0.6	0.78	neutral	0.54	neutral	3.80	23.40	deleterious	0.42	0.65	0.34	neutral	0.7	disease	0.49	neutral	0.52	disease	0	0.99	deleterious	0.2	neutral	-2	neutral	0.77	deleterious	-2.65	low_impact	0.18	medium_impact	-0.58	medium_impact	0.89	0.9	48.67	9	0.24	N	0.95	polymorphism	0.97	0.03	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15521	15521	G	T	MI.9980	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	775	259	A	S	Gcc/Tcc	-4.42	0	0	probably_damaging	1	neutral	0.55	neutral	2.51	deleterious	-3.91	neutral	-2.26	high_impact	3.8	0.94	neutral	0.47	neutral	3.48	23.10	deleterious	0.19	0.45	0.57	disease	0.75	disease	0.7	disease	0.69	disease	4	1	deleterious	0.28	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.27	medium_impact	2.26	high_impact	0.57	0.8	58.42	8.68	0.27	N	0.91	polymorphism	1	0.15	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15521	15521	G	C	MI.9981	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	775	259	A	P	Gcc/Ccc	-4.42	0	0	probably_damaging	1	neutral	1	neutral	2.44	deleterious	-6.27	deleterious	-3.8	high_impact	3.6	0.93	neutral	0.29	neutral	3.80	23.40	deleterious	0.03	0.35	0.79	disease	0.79	disease	0.72	disease	0.73	disease	5	1	deleterious	0.5	deleterious	2	deleterious	0.85	deleterious	-3.53	low_impact	1.85	high_impact	2.08	high_impact	0.52	0.8	58.42	8.68	0.23	N	0.98	polymorphism	1	0.27	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15522	15522	C	A	MI.9982	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	776	259	A	D	gCc/gAc	5.9	1	0	probably_damaging	1	neutral	0.38	neutral	2.44	deleterious	-6.93	deleterious	-4.53	high_impact	5.25	0.93	neutral	0.39	neutral	4.61	24.40	deleterious	0.02	0.35	0.71	disease	0.83	disease	0.85	disease	0.79	disease	6	1	deleterious	0.19	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.11	medium_impact	3.57	high_impact	0.39	0.8	58.42	8.68	0.77	P	1.00	polymorphism	1	0.47	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15522	15522	C	T	MI.9983	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	776	259	A	V	gCc/gTc	5.9	1	0	probably_damaging	1	neutral	0.58	neutral	2.55	deleterious	-3.08	deleterious	-3.04	high_impact	3.77	0.95	neutral	0.5	neutral	4.21	23.90	deleterious	0.08	0.35	0.48	neutral	0.74	disease	0.75	disease	0.73	disease	5	1	deleterious	0.29	neutral	2	deleterious	0.77	deleterious	-3.53	low_impact	0.3	medium_impact	2.23	high_impact	0.79	0.85	58.42	8.68	0.59	P	0.84	polymorphism	1	0.26	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15522	15522	C	G	MI.9984	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	776	259	A	G	gCc/gGc	5.9	1	0	probably_damaging	0.99	neutral	0.32	neutral	2.46	deleterious	-3.58	deleterious	-3.01	high_impact	4.21	0.93	neutral	0.51	neutral	2.39	18.78	deleterious	0.18	0.45	0.62	disease	0.61	disease	0.78	disease	0.73	disease	5	0.99	deleterious	0.17	neutral	2	deleterious	0.76	deleterious	-2.59	low_impact	0.05	medium_impact	2.63	high_impact	0.72	0.85	58.42	8.68	0.67	P	0.83	polymorphism	1	0.37	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15524	15524	A	T	MI.9985	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	778	260	N	Y	Aac/Tac	-11.52	0	0.03	probably_damaging	1	neutral	1	neutral	2.4	deleterious	-5.73	deleterious	-5.95	high_impact	5.13	0.94	neutral	0.32	neutral	3.71	23.30	deleterious	0.09	0.35	0.82	disease	0.79	disease	0.85	disease	0.79	disease	6	1	deleterious	0.5	deleterious	2	deleterious	0.83	deleterious	-3.53	low_impact	1.85	high_impact	3.46	high_impact	0.15	0.8	20.53	17.87	0.64	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15524	15524	A	G	MI.9986	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	778	260	N	D	Aac/Gac	-11.52	0	0.03	probably_damaging	0.97	neutral	0.21	neutral	2.65	neutral	-1.1	deleterious	-3.57	medium_impact	2.04	0.89	neutral	0.51	neutral	2.13	17.08	deleterious	0.34	0.5	0.32	neutral	0.62	disease	0.81	disease	0.64	disease	3	0.98	neutral	0.12	neutral	1	deleterious	0.68	deleterious	-2.14	low_impact	-0.09	medium_impact	0.66	medium_impact	0.24	0.8	20.53	17.87	0.47	N	0.34	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
chrM	15524	15524	A	C	MI.9987	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	778	260	N	H	Aac/Cac	-11.52	0	0.03	probably_damaging	1	neutral	0.55	neutral	2.41	deleterious	-4.85	deleterious	-3.71	high_impact	5.13	0.94	neutral	0.19	damaging	2.92	21.90	deleterious	0.24	0.45	0.52	disease	0.72	disease	0.85	disease	0.75	disease	5	1	deleterious	0.28	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.27	medium_impact	3.46	high_impact	0.20	0.8	20.53	17.87	0.67	P	0.81	polymorphism	1	0.23	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15525	15525	A	T	MI.9988	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	779	260	N	I	aAc/aTc	5.67	1	0	probably_damaging	1	neutral	0.41	neutral	2.4	deleterious	-6.77	deleterious	-6.68	high_impact	5.13	0.94	neutral	0.41	neutral	4.45	24.20	deleterious	0.1	0.4	0.79	disease	0.8	disease	0.82	disease	0.79	disease	6	1	deleterious	0.21	neutral	2	deleterious	0.81	deleterious	-3.53	low_impact	0.14	medium_impact	3.46	high_impact	0.07	0.8	20.53	17.87	0.72	P	0.98	polymorphism	1	0.24	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15525	15525	A	C	MI.9989	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	779	260	N	T	aAc/aCc	5.67	1	0	probably_damaging	0.98	neutral	0.4	neutral	2.44	deleterious	-4	deleterious	-4.42	high_impact	4.09	0.94	neutral	0.4	neutral	2.30	18.19	deleterious	0.16	0.45	0.58	disease	0.8	disease	0.79	disease	0.74	disease	5	0.98	deleterious	0.21	neutral	2	deleterious	0.78	deleterious	-2.31	low_impact	0.13	medium_impact	2.52	high_impact	0.23	0.8	20.53	17.87	0.62	P	0.75	polymorphism	1	0.13	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	8995	8995	G	C	MI.999	MT-ATP6	V	ENSG00000198899	ENSP00000354632	ENST00000361899	ATP6_HUMAN	P00846	4508	YP_003024031.1	469	157	A	P	Gcc/Ccc	-1.26	0	0	probably_damaging	1	deleterious	0	neutral	3.61	deleterious	-3.84	deleterious	-3.6	medium_impact	2.21	0.69	neutral	0.37	neutral	3.90	23.50	deleterious	0.11	0.65	0.83	disease	0.95	disease	0.71	disease	0.84	disease	7	1	deleterious	0	neutral	5	deleterious	0.93	deleterious	-3.6	low_impact	-1.4	low_impact	0.8	medium_impact	0.80	0.9	48.67	9	0.25	N	0.97	polymorphism	0.81	0.17	.	.	.	.	.	.	COSM1138411	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15525	15525	A	G	MI.9990	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	779	260	N	S	aAc/aGc	5.67	1	0	probably_damaging	0.92	neutral	0.41	neutral	2.48	neutral	-2.44	deleterious	-3.66	medium_impact	3.23	0.94	neutral	0.41	neutral	1.88	15.45	deleterious	0.35	0.5	0.54	disease	0.72	disease	0.78	disease	0.73	disease	5	0.92	neutral	0.25	neutral	1	deleterious	0.76	deleterious	-1.72	low_impact	0.14	medium_impact	1.74	medium_impact	0.24	0.8	20.53	17.87	0.58	N	0.89	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15526	15526	C	G	MI.9991	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	780	260	N	K	aaC/aaG	8.42	1	0	probably_damaging	0.99	neutral	0.3	neutral	2.46	deleterious	-3.71	deleterious	-4.44	high_impact	4.79	0.94	neutral	0.27	damaging	3.73	23.30	deleterious	0.22	0.45	0.5	disease	0.75	disease	0.84	disease	0.69	disease	4	0.99	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.02	medium_impact	3.16	high_impact	0.21	0.8	20.53	17.87	0.77	P	0.95	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15526	15526	C	A	MI.9992	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	780	260	N	K	aaC/aaA	8.42	1	0	probably_damaging	0.99	neutral	0.3	neutral	2.46	deleterious	-3.71	deleterious	-4.44	high_impact	4.79	0.94	neutral	0.27	damaging	4.17	23.80	deleterious	0.22	0.45	0.5	disease	0.75	disease	0.84	disease	0.69	disease	4	0.99	deleterious	0.16	neutral	2	deleterious	0.79	deleterious	-2.59	low_impact	0.02	medium_impact	3.16	high_impact	0.21	0.8	20.53	17.87	0.78	P	0.95	polymorphism	1	0.21	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15527	15527	C	G	MI.9993	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	781	261	P	A	Ccc/Gcc	-2.12	0	0	probably_damaging	0.98	neutral	0.53	neutral	1.45	deleterious	-6.11	deleterious	-6.03	high_impact	3.59	0.86	neutral	0.15	damaging	1.43	12.93	neutral	0.07	0.35	0.56	disease	0.5	disease	0.69	disease	0.64	disease	3	0.97	neutral	0.28	neutral	2	deleterious	0.74	deleterious	-2.31	low_impact	0.25	medium_impact	2.07	high_impact	0.66	0.8	57.11	8.62	0.24	N	0.84	polymorphism	1	0.07	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15527	15527	C	T	MI.9994	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	781	261	P	S	Ccc/Tcc	-2.12	0	0	probably_damaging	1	neutral	0.4	neutral	1.52	deleterious	-4.85	deleterious	-6.02	medium_impact	2.44	0.85	neutral	0.1	damaging	3.56	23.10	deleterious	0.06	0.35	0.5	disease	0.71	disease	0.64	disease	0.59	disease	2	1	deleterious	0.2	neutral	1	deleterious	0.79	deleterious	-3.53	low_impact	0.13	medium_impact	1.02	medium_impact	0.18	0.8	57.11	8.62	0.23	N	0.90	polymorphism	1	0.06	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15527	15527	C	A	MI.9995	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	781	261	P	T	Ccc/Acc	-2.12	0	0	probably_damaging	1	neutral	0.39	neutral	1.43	deleterious	-7.11	deleterious	-6.03	high_impact	4.26	0.84	neutral	0.11	damaging	3.58	23.20	deleterious	0.06	0.35	0.5	neutral	0.78	disease	0.74	disease	0.72	disease	4	1	deleterious	0.2	neutral	2	deleterious	0.78	deleterious	-3.53	low_impact	0.12	medium_impact	2.67	high_impact	0.41	0.8	57.11	8.62	0.38	N	0.96	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15528	15528	C	G	MI.9996	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	782	261	P	R	cCc/cGc	4.29	0.99	0	probably_damaging	1	neutral	0.34	neutral	1.42	deleterious	-7.58	deleterious	-6.81	high_impact	3.84	0.86	neutral	0.08	damaging	3.67	23.20	deleterious	0.03	0.35	0.62	disease	0.79	disease	0.83	disease	0.76	disease	5	1	deleterious	0.17	neutral	2	deleterious	0.82	deleterious	-3.53	low_impact	0.07	medium_impact	2.29	high_impact	0.33	0.8	57.11	8.62	0.51	N	0.80	polymorphism	1	0.10	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15528	15528	C	T	MI.9997	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	782	261	P	L	cCc/cTc	4.29	0.99	0	probably_damaging	1	neutral	0.67	neutral	1.42	deleterious	-7.16	deleterious	-7.57	high_impact	4.46	0.87	neutral	0.07	damaging	4.41	24.10	deleterious	0.04	0.35	0.72	disease	0.74	disease	0.73	disease	0.72	disease	4	1	deleterious	0.34	neutral	2	deleterious	0.80	deleterious	-3.53	low_impact	0.39	medium_impact	2.86	high_impact	0.72	0.85	57.11	8.62	0.5	N	1.00	polymorphism	1	0.11	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15528	15528	C	A	MI.9998	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	782	261	P	H	cCc/cAc	4.29	0.99	0	probably_damaging	1	neutral	0.56	neutral	1.41	deleterious	-8.81	deleterious	-6.81	high_impact	4.82	0.83	neutral	0.09	damaging	4.12	23.80	deleterious	0.05	0.35	0.8	disease	0.76	disease	0.81	disease	0.79	disease	6	1	deleterious	0.28	neutral	2	deleterious	0.83	deleterious	-3.53	low_impact	0.28	medium_impact	3.18	high_impact	0.28	0.8	57.11	8.62	0.64	P	0.71	polymorphism	1	0.20	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	damaging
chrM	15530	15530	T	A	MI.9999	MT-CYB	III	ENSG00000198727	ENSP00000354554	ENST00000361789	CYB_HUMAN	P00156	4519	YP_003024038.1	784	262	L	M	Tta/Ata	-11.75	0	0.01	probably_damaging	1	neutral	0.24	neutral	2.78	neutral	-1.2	neutral	-1.28	low_impact	1.9	0.87	neutral	0.1	damaging	3.34	22.90	deleterious	0.21	0.45	0.32	neutral	0.35	neutral	0.32	neutral	0.41	neutral	2	1	deleterious	0.12	neutral	-2	neutral	0.70	deleterious	-3.53	low_impact	-0.05	medium_impact	0.53	medium_impact	0.56	0.8	58.16	8.43	0.34	N	0.98	polymorphism	1	0.02	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	neutral
